PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2688405-4	1989	Six of seven treated patients had a significant decrease in serum ferritin and percent transferrin saturation (plasma iron/total iron-binding capacity).	Iron	118-122	transferrin	Homo sapiens	87-98
2619720-3	1989	On the other hand, ferritin H-subunit mRNA was unchanged by chronic iron load and remained in the inactive cytoplasmic pool.	Iron	68-72	ferritin heavy chain 1	Rattus norvegicus	19-37
2589245-5	1989	Although iron is known to be taken up by the hemochorial placenta via trophoblast brush border receptors for transferrin, further iron handling within the placenta is poorly understood.	Iron	9-13	transferrin	Homo sapiens	109-120
2688405-4	1989	Six of seven treated patients had a significant decrease in serum ferritin and percent transferrin saturation (plasma iron/total iron-binding capacity).	Iron	129-133	transferrin	Homo sapiens	87-98
2512934-3	1989	Superoxide dismutase, alone or in combination with catalase, strongly inhibited 6-hydroxydopamine oxidation and greatly enhanced the amount of ferritin iron release.	Iron	152-156	catalase	Homo sapiens	51-59
2557840-1	1989	Relative impact of myeloperoxidase and lactoferrin release on hydroxyl-radical production by iron-supplemented neutrophils assessed by spin-trapping techniques.	Iron	93-97	myeloperoxidase	Homo sapiens	19-34
2512934-8	1989	Superoxide dismutase, and to a lesser extent catalase, stimulated peroxidation catalysed by adventitious levels of iron, but in the presence of ferritin, each enzyme was inhibitory.	Iron	115-119	catalase	Homo sapiens	45-53
2583116-4	1989	The IREs from the ferritin and transferrin receptor mRNAs compete in an in vitro assay for interaction with a cytoplasmic protein; the activity of this IRE-binding protein is dependent upon the iron status of the cells.	Iron	194-198	transferrin	Homo sapiens	31-42
2614472-2	1989	Aluminium is known to be transported by the iron transport protein transferrin.	Iron	44-48	transferrin	Homo sapiens	67-78
2614472-6	1989	In contrast, the distribution of iron in the brain showed an inverse correlation with transferrin receptor density with highest iron levels present in the globus pallidus, an area of low transferrin receptor density.	Iron	33-37	transferrin	Homo sapiens	86-97
2614472-6	1989	In contrast, the distribution of iron in the brain showed an inverse correlation with transferrin receptor density with highest iron levels present in the globus pallidus, an area of low transferrin receptor density.	Iron	33-37	transferrin	Homo sapiens	187-198
2614472-6	1989	In contrast, the distribution of iron in the brain showed an inverse correlation with transferrin receptor density with highest iron levels present in the globus pallidus, an area of low transferrin receptor density.	Iron	128-132	transferrin	Homo sapiens	86-97
2614472-8	1989	The discrepancy between iron distribution and transferrin receptor distribution suggests that further, as yet uncharacterized mechanisms, govern the distribution of brain iron.	Iron	171-175	transferrin	Homo sapiens	46-57
2693045-5	1989	Maintenance of an adequate iron supply is essential and iron supplementation is recommended if serum ferritin is below 100 to 150 micrograms/L or transferrin saturation is less than 20%.	Iron	56-60	transferrin	Homo sapiens	146-157
2636578-1	1989	Iron loading anaemias are characterized by anaemia, high serum iron, transferrin saturation and ferritin values, and haemosiderin deposits in parenchymal cells and reticuloendothelial tissue with or without organ dysfunction.	Iron	0-4	transferrin	Homo sapiens	69-80
2608449-10	1989	Since transferrin is indispensible for the utilization of iron by the heme-synthesizing red cell precursors, transferrin concentration in the blood is the limiting factor for the utilization of iron in hemoglobin synthesis.	Iron	58-62	transferrin	Rattus norvegicus	6-17
2608449-10	1989	Since transferrin is indispensible for the utilization of iron by the heme-synthesizing red cell precursors, transferrin concentration in the blood is the limiting factor for the utilization of iron in hemoglobin synthesis.	Iron	58-62	transferrin	Rattus norvegicus	109-120
2608449-10	1989	Since transferrin is indispensible for the utilization of iron by the heme-synthesizing red cell precursors, transferrin concentration in the blood is the limiting factor for the utilization of iron in hemoglobin synthesis.	Iron	194-198	transferrin	Rattus norvegicus	109-120
2630018-2	1989	It was found that after iron particles were implanted into the vitreous bodies (1) iron concentration in the aqueous humour rose rapidly and significantly (n = 24, P less than 0.01), (2) malondialdehyde (MDA) a degradation metabolite of lipid peroxidation, in the retinas increased significantly (n = 24, P less than 0.05), and (3) superoxide dismutase (SOD) activity decreased (n = 11, P less than 0.05).	Iron	24-28	superoxide dismutase 1	Homo sapiens	332-352
2630018-2	1989	It was found that after iron particles were implanted into the vitreous bodies (1) iron concentration in the aqueous humour rose rapidly and significantly (n = 24, P less than 0.01), (2) malondialdehyde (MDA) a degradation metabolite of lipid peroxidation, in the retinas increased significantly (n = 24, P less than 0.05), and (3) superoxide dismutase (SOD) activity decreased (n = 11, P less than 0.05).	Iron	24-28	superoxide dismutase 1	Homo sapiens	354-357
2556275-2	1989	A hypothetical model of the complex formed between the iron-sulfur protein rubredoxin and the tetraheme cytochrome c3 from the sulfate-reducing bacteria Desulfovibrio vulgaris (Hildenborough) has been proposed utilizing computer graphic modeling, computational methods and NMR spectroscopy.	Iron	55-59	cytochrome c, somatic	Homo sapiens	104-116
2554814-8	1989	In addition, Fe(II)-mediated DMPO/.OH formation increased when the iron was chelated to either EDTA or DTPA rather than being inhibited as for Co(II).	Iron	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
2583116-5	1989	Based on further deletion analysis reported here, the sequence required for iron regulation of the transferrin receptor have been limited to 250 nucleotides which we have produced synthetically and cloned.	Iron	76-80	transferrin	Homo sapiens	99-110
2583116-8	1989	Moreover, deletion of a single cytosine residue from each of the three IREs in the synthetic regulatory element eliminates high-affinity binding to the IRE-binding protein in vitro and results in low levels of iron-independent transferrin receptor expression, consistent with production of a constitutively unstable mRNA.	Iron	210-214	transferrin	Homo sapiens	227-238
2583116-9	1989	These data indicate that the ability of the mRNA to interact with the IRE-binding protein is required for regulation of transferrin receptor mRNA levels by iron.	Iron	156-160	transferrin	Homo sapiens	120-131
2487794-2	1989	Transferrin not only carries iron in the plasma but also delivers it to the various cells by binding to a diffuse specific cell receptor; it also acts by chelating cell iron.	Iron	29-33	transferrin	Homo sapiens	0-11
2615188-2	1989	Tubule fluid iron is determined by the magnitude of the glomerular leak for transferrin and the iron saturation of transferrin.	Iron	13-17	transferrin	Rattus norvegicus	76-87
2615188-2	1989	Tubule fluid iron is determined by the magnitude of the glomerular leak for transferrin and the iron saturation of transferrin.	Iron	13-17	transferrin	Rattus norvegicus	115-126
2615188-2	1989	Tubule fluid iron is determined by the magnitude of the glomerular leak for transferrin and the iron saturation of transferrin.	Iron	96-100	transferrin	Rattus norvegicus	115-126
2812898-1	1989	Newborn infants of poorly controlled insulin-dependent diabetic mothers demonstrate a redistribution of iron from serum and tissue stores into red blood cells.	Iron	104-108	insulin	Homo sapiens	37-44
2682525-2	1989	This increase in mutation frequency is abolished when the inhibitors desferrioxamine, superoxide dismutase, catalase or dimethyl sulfoxide are included in the initial reaction or when the iron/EDTA complex is omitted, a strong indication that the premutagenic damage arises as a result of direct attack by hydroxyl radical generated in a superoxide driven Fenton reaction.	Iron	188-192	catalase	Homo sapiens	108-116
2592487-3	1989	The pattern changed when iron-free transferrin was treated with neuraminidase, which splits off the sialic acid from the carbohydrate chains.	Iron	25-29	transferrin	Homo sapiens	35-46
2533128-0	1989	Utilization of transferrin-bound iron by Haemophilus species of human and porcine origins.	Iron	33-37	transferrin	Homo sapiens	15-26
2533128-1	1989	Haemophilus influenzae and H. haemolyticus acquired iron bound to human transferrin but not to human lactoferrin, ovo- or porcine transferrins.	Iron	52-56	transferrin	Homo sapiens	72-83
2533128-2	1989	Conversely the swine pathogens H. pleuropneumoniae and H. parasuis used iron bound only to porcine transferrin.	Iron	72-76	transferrin	Homo sapiens	99-110
2533128-4	1989	The latter 3 Haemophilus species appear to sequester transferrin bound iron via a siderophore-independent mechanism.	Iron	71-75	transferrin	Homo sapiens	53-64
2681511-7	1989	Preliminary studies indicate that measurement of the serum transferrin receptor may be the most reliable way to assess deficits in tissue iron supply.	Iron	138-142	transferrin	Homo sapiens	59-70
2681514-7	1989	These data demonstrate continuously high transferrin saturation values, greater than 69% in most treated and untreated male and female homozygotes, resulting in hepatic iron accumulation of non-transferrin-bound iron from the portal circulation.	Iron	169-173	transferrin	Homo sapiens	41-52
2681514-7	1989	These data demonstrate continuously high transferrin saturation values, greater than 69% in most treated and untreated male and female homozygotes, resulting in hepatic iron accumulation of non-transferrin-bound iron from the portal circulation.	Iron	212-216	transferrin	Homo sapiens	41-52
2681515-1	1989	Over the last 10 years there has been steady progress in our understanding of the structure of the iron-binding proteins transferrin and ferritin, and the transferrin receptor.	Iron	99-103	transferrin	Homo sapiens	121-132
2679134-6	1989	The uptake of non-transferrin-bound iron was also increased in HD and LD hepatocytes at 24 h but only in HD cells at 1 h. Transferrin binding was not altered in LPS-treated cells from ND rats but was depressed in cells from LPS-treated rats both at 1 h and at 24 h after injection.	Iron	36-40	transferrin	Rattus norvegicus	18-29
2679134-6	1989	The uptake of non-transferrin-bound iron was also increased in HD and LD hepatocytes at 24 h but only in HD cells at 1 h. Transferrin binding was not altered in LPS-treated cells from ND rats but was depressed in cells from LPS-treated rats both at 1 h and at 24 h after injection.	Iron	36-40	transferrin	Rattus norvegicus	122-133
2487794-2	1989	Transferrin not only carries iron in the plasma but also delivers it to the various cells by binding to a diffuse specific cell receptor; it also acts by chelating cell iron.	Iron	169-173	transferrin	Homo sapiens	0-11
2487794-5	1989	Iron overload, such as that typical of hyperhemolysis or hemochromatosis, profoundly impairs its metabolism by saturating and/or altering transferrin and ferritin, by freeing iron from any regulated transport, thus allowing parenchymal deposition and damage.	Iron	0-4	transferrin	Homo sapiens	138-149
2487794-7	1989	Studies using cellular models attempt to evaluate such differences in terms of altered properties of the iron proteins or their cell receptors, and of the different cell responsivity to non-transferrin iron.	Iron	202-206	transferrin	Homo sapiens	190-201
2811766-10	1989	Since the iron uptake by the erythropoietic cells is mediated by transferrin in a further series of experiments the serum transferrin concentration was investigated in malignant diseases.	Iron	10-14	transferrin	Homo sapiens	65-76
2478317-3	1989	Because of the importance of iron in basic cell metabolism we have hypothesized that iron (mobilized by Tf) may be a permissive agent in the process of myelination.	Iron	29-33	transferrin	Rattus norvegicus	104-106
2478317-3	1989	Because of the importance of iron in basic cell metabolism we have hypothesized that iron (mobilized by Tf) may be a permissive agent in the process of myelination.	Iron	85-89	transferrin	Rattus norvegicus	104-106
2478317-13	1989	The temporal association of Tf and myelin production suggests that further study is warranted regarding the possibility that the Tf-iron system supports or perhaps even permits the initiation of the process of myelination.	Iron	132-136	transferrin	Rattus norvegicus	28-30
2478317-13	1989	The temporal association of Tf and myelin production suggests that further study is warranted regarding the possibility that the Tf-iron system supports or perhaps even permits the initiation of the process of myelination.	Iron	132-136	transferrin	Rattus norvegicus	129-131
2584367-0	1989	[Regulation of ferritin and transferrin synthesis in hepatocytes depending on iron status of rats].	Iron	78-82	transferrin	Rattus norvegicus	28-39
2557655-9	1989	In conclusion reduced ACTH and cortisol reserves detected in some thalassemic patients may be related to iron infiltration in the pituitary and adrenal glands.	Iron	105-109	proopiomelanocortin	Homo sapiens	22-26
2694981-4	1989	The mean saturation of serum transferrin with iron fell from 42 +/- 17% in the control group to 37 +/- 9% in the malaria group.	Iron	46-50	transferrin	Homo sapiens	29-40
2694981-5	1989	It is suggested that the increase in transferrin concentration in the sera of malaria subjects probably resulted from an increase in the rate of transferrin synthesis, perhaps in response to the raised serum iron and/or the hypoxia which is known to be associated with malaria infection.	Iron	208-212	transferrin	Homo sapiens	37-48
2694981-5	1989	It is suggested that the increase in transferrin concentration in the sera of malaria subjects probably resulted from an increase in the rate of transferrin synthesis, perhaps in response to the raised serum iron and/or the hypoxia which is known to be associated with malaria infection.	Iron	208-212	transferrin	Homo sapiens	145-156
2795208-9	1989	In contrast, the iron-transferrin complex may be useful for measuring and imaging transferrin-specific receptors in brain and tumor tissue.	Iron	17-21	transferrin	Rattus norvegicus	22-33
2795208-9	1989	In contrast, the iron-transferrin complex may be useful for measuring and imaging transferrin-specific receptors in brain and tumor tissue.	Iron	17-21	transferrin	Rattus norvegicus	82-93
2678449-0	1989	The transferrin receptor: a key function in iron metabolism.	Iron	44-48	transferrin	Homo sapiens	4-15
2678449-2	1989	Its uptake by cells requires specific binding of the major serum iron-transport protein, transferrin, to cell surface transferrin receptors, followed by endocytosis of the receptor-ligand complexes and release of iron from endosomal vesicles to the cytoplasm.	Iron	65-69	transferrin	Homo sapiens	89-100
2678449-2	1989	Its uptake by cells requires specific binding of the major serum iron-transport protein, transferrin, to cell surface transferrin receptors, followed by endocytosis of the receptor-ligand complexes and release of iron from endosomal vesicles to the cytoplasm.	Iron	65-69	transferrin	Homo sapiens	118-129
2678449-5	1989	Recent studies are presented which establish that iron plays an important role in the maintenance of its own homeostasis by regulating coordinately the expression of both the transferrin receptor and ferritin.	Iron	50-54	transferrin	Homo sapiens	175-186
2550081-12	1989	Both the arrhythmia and the free radical signal were partially blocked by SOD, catalase and ICRF-187, indicating that iron-dependent oxygen radical formation from BMY-25282 (and possibly other compounds) is involved, in part, in inducing toxic manifestations in the rat heart and possibly in clinic.	Iron	118-122	catalase	Rattus norvegicus	79-87
2811766-10	1989	Since the iron uptake by the erythropoietic cells is mediated by transferrin in a further series of experiments the serum transferrin concentration was investigated in malignant diseases.	Iron	10-14	transferrin	Homo sapiens	122-133
2811766-12	1989	This correlation supports the concept of a defect in erythropoiesis due to an impaired transferrin mediated iron supply caused by tumor induced hypotransferrinemia.	Iron	108-112	transferrin	Homo sapiens	87-98
2805610-3	1989	Similarly, free iron was also significantly higher in RA SF than in OA SF, whereas the ferritin saturation index, transferrin saturation index and bound iron were more significantly decreased in RA SF than in OA SF.	Iron	16-20	OAP	Homo sapiens	68-73
2670597-2	1989	An iron colloidal suspension with a CD10 monoclonal antibody (MoAb) against the common acute lymphoblastic leukemia antigen (CALLA) covalently bound to the surface of the particles has been used.	Iron	3-7	membrane metalloendopeptidase	Homo sapiens	36-40
2670597-2	1989	An iron colloidal suspension with a CD10 monoclonal antibody (MoAb) against the common acute lymphoblastic leukemia antigen (CALLA) covalently bound to the surface of the particles has been used.	Iron	3-7	membrane metalloendopeptidase	Homo sapiens	80-123
2666676-1	1989	Iron (Fe) depletion with anti-transferrin (Tf) receptor monoclonal antibodies (MAbs), Fe chelators, or gallium (Ga) salts inhibits in vitro and in vivo growth of tumor cells.	Iron	0-4	transferrin	Homo sapiens	30-41
2775256-1	1989	Transferrin (Tf), the major iron-binding protein in the plasma of vertebrate species is an essential growth factor for cells in serum-free media and appears to be involved in the regulation of growth and differentiation of human tissues.	Iron	28-32	transferrin	Homo sapiens	0-11
2775256-1	1989	Transferrin (Tf), the major iron-binding protein in the plasma of vertebrate species is an essential growth factor for cells in serum-free media and appears to be involved in the regulation of growth and differentiation of human tissues.	Iron	28-32	transferrin	Homo sapiens	13-15
2788773-0	1989	Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor.	Iron	55-59	tumor necrosis factor	Mus musculus	74-95
2788773-2	1989	Recombinant TNF caused a significant decrease in serum iron levels after 6 hours, but none of the mediators caused significant changes in total iron binding capacity at this time, although TNS caused a significant increase in total iron binding capacity after 24 hours.	Iron	55-59	tumor necrosis factor	Mus musculus	12-15
2788773-6	1989	When peritoneal macrophages from normal mice were treated with the mediators in vitro and then pulsed with labeled immune complexes, recombinant TNF caused a significant decrease in iron release, but none of the other mediators had any effect.	Iron	182-186	tumor necrosis factor	Mus musculus	145-148
2666676-1	1989	Iron (Fe) depletion with anti-transferrin (Tf) receptor monoclonal antibodies (MAbs), Fe chelators, or gallium (Ga) salts inhibits in vitro and in vivo growth of tumor cells.	Iron	6-8	transferrin	Homo sapiens	30-41
2745981-3	1989	Both iron chelators and free radical scavengers inhibited this enhanced secretion of TNF, implying the involvement of free radicals via a Fenton-type reaction.	Iron	5-9	tumor necrosis factor	Mus musculus	85-88
2745981-6	1989	Pretreatment with the iron chelator, desferal, or the free radical scavenger, BHA, inhibited TNF release in these animals.	Iron	22-26	tumor necrosis factor	Mus musculus	93-96
2771641-2	1989	A cytoplasmic protein (IRE-BP) binds to these cis-acting elements and mediates the translational regulation of ferritin H- and L-chain mRNA and the iron-dependent stability of transferrin receptor (TfR) mRNA.	Iron	148-152	basic leucine zipper nuclear factor 1	Homo sapiens	2-21
2758037-9	1989	Under normal conditions, there is no significant intracellular or intramitochondrial iron pool in reticulocytes, which are therefore dependent upon continuous delivery of transferrin-bound iron to maintain heme synthesis.	Iron	189-193	transferrin	Rattus norvegicus	171-182
2641670-9	1989	Our results suggest that impaired phagocyte function in patients with iron overload may be due to non-transferrin bound iron-mediated peroxidation of membrane lipids.	Iron	70-74	transferrin	Homo sapiens	102-113
2757026-0	1989	Iron management during recombinant human erythropoietin therapy.	Iron	0-4	erythropoietin	Homo sapiens	41-55
2546742-1	1989	Transferrin, a serum iron-binding protein, delivers iron to the cell after binding to specific receptors on the cell surface and is an important component of culture medium for virtually all cell lines, including the FRTL5 line of rat thyroid follicular cells.	Iron	21-25	transferrin	Rattus norvegicus	0-11
2743310-1	1989	In previous studies, we have demonstrated that transferrin-gallium inhibits cellular proliferation by a mechanism whereby cellular iron utilization is impaired.	Iron	131-135	transferrin	Homo sapiens	47-58
2743310-4	1989	Cells exposed to relatively low concentrations of transferrin-indium exhibit markedly increased transferrin receptor expression but, as with transferrin-gallium, these cells incorporate an inappropriately low amount of iron, suggesting that there is a defect in the release of internalized iron from transferrin.	Iron	219-223	transferrin	Homo sapiens	50-61
2743310-4	1989	Cells exposed to relatively low concentrations of transferrin-indium exhibit markedly increased transferrin receptor expression but, as with transferrin-gallium, these cells incorporate an inappropriately low amount of iron, suggesting that there is a defect in the release of internalized iron from transferrin.	Iron	290-294	transferrin	Homo sapiens	50-61
2743310-5	1989	In further studies, we utilize a monoclonal antibody against transferrin receptor that inhibits transferrin-mediated iron uptake.	Iron	117-121	transferrin	Homo sapiens	61-72
2743310-5	1989	In further studies, we utilize a monoclonal antibody against transferrin receptor that inhibits transferrin-mediated iron uptake.	Iron	117-121	transferrin	Homo sapiens	96-107
2507316-5	1989	The rates of receptor endocytosis and recycling were measured and the accumulation of iron by cells incubated with [59Fe]diferric transferrin was investigated.	Iron	86-90	transferrin	Homo sapiens	130-141
2546742-1	1989	Transferrin, a serum iron-binding protein, delivers iron to the cell after binding to specific receptors on the cell surface and is an important component of culture medium for virtually all cell lines, including the FRTL5 line of rat thyroid follicular cells.	Iron	52-56	transferrin	Rattus norvegicus	0-11
2754306-0	1989	Transfusional iron overload in patients undergoing dialysis: treatment with erythropoietin and phlebotomy.	Iron	14-18	erythropoietin	Homo sapiens	76-90
2754306-8	1989	When compared with a group of five patients without transfusional iron overload who received recombinant human erythropoietin and did not undergo therapeutic phlebotomy, the patients with iron overload had much greater iron losses and a larger decrease in serum ferritin levels.	Iron	188-192	erythropoietin	Homo sapiens	111-125
2754306-8	1989	When compared with a group of five patients without transfusional iron overload who received recombinant human erythropoietin and did not undergo therapeutic phlebotomy, the patients with iron overload had much greater iron losses and a larger decrease in serum ferritin levels.	Iron	188-192	erythropoietin	Homo sapiens	111-125
2573050-9	1989	These data further suggest that the complex between P450Coh and eto- and metomidate may be particularly strong and independent from the redox state of the haem iron.	Iron	160-164	RUNX1 translocation partner 1	Mus musculus	64-67
2532702-0	1989	Responses of Haemophilus pleuropneumoniae to iron restriction: changes in the outer membrane protein profile and the removal of iron from porcine transferrin.	Iron	45-49	transferrin	Homo sapiens	146-157
2532702-0	1989	Responses of Haemophilus pleuropneumoniae to iron restriction: changes in the outer membrane protein profile and the removal of iron from porcine transferrin.	Iron	128-132	transferrin	Homo sapiens	146-157
2532702-4	1989	Although soluble siderophore production could not be detected, growth of the organisms on an iron-restricted medium was enhanced by the presence of porcine transferrin but not by bovine or human transferrin.	Iron	93-97	serotransferrin	Bos taurus	156-167
2532702-5	1989	The results suggest that H. pleuropneumoniae possesses a specific transferrin receptor, perhaps in the form of an iron-regulated outer membrane protein.	Iron	114-118	transferrin	Homo sapiens	66-77
2504356-0	1989	Poor response to treatment of renal anaemia with erythropoietin corrected by iron given intravenously.	Iron	77-81	erythropoietin	Homo sapiens	49-63
2474819-6	1989	Iron-responsive elements (IREs) are RNA stem-loops present in the mRNAs encoding ferritin and the transferrin receptor.	Iron	0-4	transferrin	Homo sapiens	98-109
2752428-0	1989	A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA.	Iron	45-49	transferrin	Homo sapiens	85-96
2752428-1	1989	Iron regulates human transferrin receptor (hTR) expression by modulating the stability of cytoplasmic hTR mRNA.	Iron	0-4	telomerase RNA component	Homo sapiens	43-46
2752428-1	1989	Iron regulates human transferrin receptor (hTR) expression by modulating the stability of cytoplasmic hTR mRNA.	Iron	0-4	telomerase RNA component	Homo sapiens	102-105
2752428-7	1989	Binding of the factor to hTR mRNA palindromes was competed by 5" regulatory sequences of ferritin mRNA, which are responsible for iron-dependent translational control.	Iron	130-134	telomerase RNA component	Homo sapiens	25-28
2752428-8	1989	These results suggest that cellular iron maintains its homeostasis by coordinate regulation of hTR and ferritin expression via a common factor.	Iron	36-40	telomerase RNA component	Homo sapiens	95-98
2774505-1	1989	We used immunohistochemical studies to demonstrate that transferrin (the iron mobilization protein) and ferritin (the iron storage protein) are specifically localized in oligodendrocytes in gray and white matter of the human central nervous system.	Iron	73-77	transferrin	Homo sapiens	56-67
2741855-3	1989	The total amount of absorbed manganese was significantly higher from the non--iron-fortified cow"s milk formula (2 mg/L of iron) as compared with human milk, while no significant differences were observed for the other milks and formulas.	Iron	78-82	Weaning weight-maternal milk	Bos taurus	99-103
2741913-0	1989	Hemolysates reduce iron released from transferrin.	Iron	19-23	transferrin	Homo sapiens	38-49
2741913-1	1989	Transferrin donates iron to reticulocytes as follows: it binds to a receptor on the reticulocyte surface; the complex is endocytosed; both irons are released and the transferrin is recycled to the cell exterior.	Iron	20-24	transferrin	Homo sapiens	0-11
2741913-1	1989	Transferrin donates iron to reticulocytes as follows: it binds to a receptor on the reticulocyte surface; the complex is endocytosed; both irons are released and the transferrin is recycled to the cell exterior.	Iron	20-24	transferrin	Homo sapiens	166-177
2741913-1	1989	Transferrin donates iron to reticulocytes as follows: it binds to a receptor on the reticulocyte surface; the complex is endocytosed; both irons are released and the transferrin is recycled to the cell exterior.	Iron	139-144	transferrin	Homo sapiens	0-11
2741913-2	1989	It has been proposed that the trigger for iron release after transferrin endocytosis is acidification of the endocytic vesicle.	Iron	42-46	transferrin	Homo sapiens	61-72
2741913-3	1989	But this could account for removal of only one of transferrin"s two irons, since only one of the irons is labile at acid pH.	Iron	68-73	transferrin	Homo sapiens	50-61
2741913-3	1989	But this could account for removal of only one of transferrin"s two irons, since only one of the irons is labile at acid pH.	Iron	97-102	transferrin	Homo sapiens	50-61
2741913-4	1989	Moreover, iron continues to be removed from transferrin when acidification of the vesicle is blocked by a chloride-transport inhibitor.	Iron	10-14	transferrin	Homo sapiens	44-55
2741913-5	1989	Thus a detailed explanation of iron removal from transferrin remains elusive.	Iron	31-35	transferrin	Homo sapiens	49-60
2741913-6	1989	In earlier work we showed that iron can be removed from transferrin by whole hemolysates and also by the combined action of hemoglobin and ATP at pH 7.	Iron	31-35	transferrin	Homo sapiens	56-67
2741913-7	1989	We now show that the iron released from transferrin by hemolysates, and by hemoglobin and ATP, is in the Fe(II) oxidation state.	Iron	21-25	transferrin	Homo sapiens	40-51
2741913-9	1989	The reductive release of iron from transferrin is rapid enough to account for all the iron processed by a young reticulocyte.	Iron	25-29	transferrin	Homo sapiens	35-46
2741913-9	1989	The reductive release of iron from transferrin is rapid enough to account for all the iron processed by a young reticulocyte.	Iron	86-90	transferrin	Homo sapiens	35-46
2741913-10	1989	We speculate that transferrin iron may be reduced to Fe(II) before reaching the mitochondria.	Iron	30-34	transferrin	Homo sapiens	18-29
2775718-0	1989	Mossbauer spectroscopic study of the initial stages of iron-core formation in horse spleen apoferritin: evidence for both isolated Fe(III) atoms and oxo-bridged Fe(III) dimers as early intermediates.	Iron	55-59	ferritin heavy chain	Equus caballus	91-102
2777088-5	1989	However, the predicted amino acid sequences of the encoded LOX enzymes show certain conserved regions that are presumably involved in their catalytic activity, in particular a cluster of five conserved histidines that we predict chelate the iron moiety involved in the active site.	Iron	241-245	seed linoleate 9S-lipoxygenase-3	Glycine max	59-62
2735945-6	1989	These results led to the selection of two compounds, erythralosamine-2"-benzoate and erythralosamine-2",3-diacetate, which exhibited a particularly high affinity for macrolide inducible cytochrome P-450 and were very good precursors of cytochrome P-450-iron-metabolite complex formation.	Iron	253-257	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	186-202
2735945-6	1989	These results led to the selection of two compounds, erythralosamine-2"-benzoate and erythralosamine-2",3-diacetate, which exhibited a particularly high affinity for macrolide inducible cytochrome P-450 and were very good precursors of cytochrome P-450-iron-metabolite complex formation.	Iron	253-257	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	236-252
2769797-4	1989	This paper shows that axotomy results in a strong increase in transferrin receptors (TfRs) in regenerating motor neurons and that this phenomenon is functionally associated with an elevated uptake of exogenous iron.	Iron	210-214	transferrin	Homo sapiens	62-73
2732236-2	1989	Reaction of horse myoglobin with H2O2 oxidizes the iron to the ferryl (Fe(IV) = O) state and produces a protein radical that is rapidly dissipated by poorly understood mechanisms.	Iron	51-55	myoglobin	Equus caballus	18-27
2542309-5	1989	Both loss of iron binding capacity and transferrin iodination by either the myeloperoxidase system or activated neutrophils were blocked by azide or catalase.	Iron	13-17	catalase	Homo sapiens	149-157
2542309-5	1989	Both loss of iron binding capacity and transferrin iodination by either the myeloperoxidase system or activated neutrophils were blocked by azide or catalase.	Iron	13-17	myeloperoxidase	Homo sapiens	76-91
2542309-0	1989	Inactivation of transferrin iron binding capacity by the neutrophil myeloperoxidase system.	Iron	28-32	transferrin	Homo sapiens	16-27
2542309-7	1989	The kinetics of changes in iron binding capacity and iodination closely paralleled one another, exhibiting t1/2 values of less than 1 min for the myeloperoxidase-H2O2 system, 3-4 min for the myeloperoxidase-glucose oxidase system, and 8 min for the neutrophil system.	Iron	27-31	myeloperoxidase	Homo sapiens	146-161
2542309-0	1989	Inactivation of transferrin iron binding capacity by the neutrophil myeloperoxidase system.	Iron	28-32	myeloperoxidase	Homo sapiens	68-83
2542309-7	1989	The kinetics of changes in iron binding capacity and iodination closely paralleled one another, exhibiting t1/2 values of less than 1 min for the myeloperoxidase-H2O2 system, 3-4 min for the myeloperoxidase-glucose oxidase system, and 8 min for the neutrophil system.	Iron	27-31	myeloperoxidase	Homo sapiens	191-206
2542309-2	1989	Such treatment resulted in a marked loss in transferrin iron binding capacity as well as concomitant iodination of transferrin.	Iron	56-60	transferrin	Homo sapiens	44-55
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	118-122	myeloperoxidase	Homo sapiens	53-68
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	118-122	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	118-122	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	53-68
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	53-68
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	53-68
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	53-68
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-8	1989	That the occupied binding site is protected from the myeloperoxidase system was suggested by 1) a failure to mobilize iron from iron-loaded transferrin, 2) an inverse correlation between initial iron saturation and myeloperoxidase-mediated loss of iron binding capacity, and 3) decreased myeloperoxidase-mediated iodination of iron-loaded versus apotransferrin.	Iron	128-132	myeloperoxidase	Homo sapiens	215-230
2542309-9	1989	Since as little as 1 atom of iodide bound per molecule of transferrin was associated with substantial losses in iron binding capacity, there appears to be a high specificity of myeloperoxidase-catalyzed iodination for residues at or near the iron binding sites.	Iron	112-116	transferrin	Homo sapiens	58-69
2542309-9	1989	Since as little as 1 atom of iodide bound per molecule of transferrin was associated with substantial losses in iron binding capacity, there appears to be a high specificity of myeloperoxidase-catalyzed iodination for residues at or near the iron binding sites.	Iron	112-116	myeloperoxidase	Homo sapiens	177-192
2542309-9	1989	Since as little as 1 atom of iodide bound per molecule of transferrin was associated with substantial losses in iron binding capacity, there appears to be a high specificity of myeloperoxidase-catalyzed iodination for residues at or near the iron binding sites.	Iron	242-246	transferrin	Homo sapiens	58-69
2542309-9	1989	Since as little as 1 atom of iodide bound per molecule of transferrin was associated with substantial losses in iron binding capacity, there appears to be a high specificity of myeloperoxidase-catalyzed iodination for residues at or near the iron binding sites.	Iron	242-246	myeloperoxidase	Homo sapiens	177-192
2542309-11	1989	These observations document the ability of neutrophils to inactivate transferrin iron binding capacity via the secretion of myeloperoxidase, formation of H2O2, and subsequent myeloperoxidase-catalyzed iodination.	Iron	81-85	transferrin	Homo sapiens	69-80
2735408-5	1989	When livers were perfused with increasing concentrations of transferrin the uptake into the different peaks of transferrin and iron increased in a curvilinear fashion, which indicated that uptake occurred by saturable and nonsaturable processes, both of which increased in iron deficiency.	Iron	127-131	transferrin	Rattus norvegicus	60-71
2542309-11	1989	These observations document the ability of neutrophils to inactivate transferrin iron binding capacity via the secretion of myeloperoxidase, formation of H2O2, and subsequent myeloperoxidase-catalyzed iodination.	Iron	81-85	myeloperoxidase	Homo sapiens	124-139
2542309-11	1989	These observations document the ability of neutrophils to inactivate transferrin iron binding capacity via the secretion of myeloperoxidase, formation of H2O2, and subsequent myeloperoxidase-catalyzed iodination.	Iron	81-85	myeloperoxidase	Homo sapiens	175-190
2708361-2	1989	Transferrin (Tf), the iron transport protein of vertebrate serum, is mainly synthesized in the liver.	Iron	22-26	transferrin	Homo sapiens	0-11
2714421-1	1989	The expression of transferrin receptors on cells is felt to reflect iron requirements for proliferation or for hemoglobin production.	Iron	68-72	transferrin	Homo sapiens	18-29
2714421-2	1989	We have recently shown that transferrin-gallium (Tf-Ga) complexes bind to cellular transferrin receptors and inhibit cellular iron incorporation.	Iron	126-130	transferrin	Homo sapiens	28-39
2714421-6	1989	Transferrin-iron (Tf-Fe) added to the Tf-Ga-containing cultures restored colony growth; however, this effect was best seen when Tf-Fe was added at day 0 of incubation.	Iron	12-16	transferrin	Homo sapiens	0-11
2714421-6	1989	Transferrin-iron (Tf-Fe) added to the Tf-Ga-containing cultures restored colony growth; however, this effect was best seen when Tf-Fe was added at day 0 of incubation.	Iron	21-23	transferrin	Homo sapiens	0-11
2714421-6	1989	Transferrin-iron (Tf-Fe) added to the Tf-Ga-containing cultures restored colony growth; however, this effect was best seen when Tf-Fe was added at day 0 of incubation.	Iron	131-133	transferrin	Homo sapiens	0-11
2721585-0	1989	Growth-stimulating effect of transferrin on a hybridoma cell line: relation to transferrin iron-transporting function.	Iron	91-95	serotransferrin	Bos taurus	29-40
2721585-0	1989	Growth-stimulating effect of transferrin on a hybridoma cell line: relation to transferrin iron-transporting function.	Iron	91-95	serotransferrin	Bos taurus	79-90
2721585-2	1989	The cells were precultivated in protein-free medium supplemented either with ferric citrate (cells with a high intracellular iron level) or with iron-saturated transferrin (cells with a low intracellular iron level).	Iron	145-149	serotransferrin	Bos taurus	160-171
2721585-2	1989	The cells were precultivated in protein-free medium supplemented either with ferric citrate (cells with a high intracellular iron level) or with iron-saturated transferrin (cells with a low intracellular iron level).	Iron	145-149	serotransferrin	Bos taurus	160-171
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	160-164	transferrin	Homo sapiens	56-67
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	160-164	transferrin	Homo sapiens	69-71
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	160-164	transferrin	Homo sapiens	148-159
2730003-12	1989	Glutathione, superoxide dismutase, and catalase modulated lipid peroxidation in a way consistent with their effects being mainly on ferritin-iron release.	Iron	141-145	catalase	Homo sapiens	39-47
2721585-5	1989	Replacement of pig transferrin with bovine transferrin resulted in similar intracellular iron levels, but the growth-stimulating effect of bovine transferrin was more than one order of magnitude lower.	Iron	89-93	serotransferrin	Bos taurus	43-54
2721585-5	1989	Replacement of pig transferrin with bovine transferrin resulted in similar intracellular iron levels, but the growth-stimulating effect of bovine transferrin was more than one order of magnitude lower.	Iron	89-93	serotransferrin	Bos taurus	43-54
2721585-6	1989	Cells with a high intracellular iron level grew equally well when cultivated with iron-saturated transferrin or with apotransferrin + deferoxamine (2 micrograms/ml).	Iron	32-36	serotransferrin	Bos taurus	97-108
2721585-6	1989	Cells with a high intracellular iron level grew equally well when cultivated with iron-saturated transferrin or with apotransferrin + deferoxamine (2 micrograms/ml).	Iron	82-86	serotransferrin	Bos taurus	97-108
2721585-7	1989	On the other hand, cells with a low intracellular iron level required iron-saturated transferrin for further growth and apotransferrin + deferoxamine was ineffective.	Iron	50-54	serotransferrin	Bos taurus	85-96
2721585-7	1989	On the other hand, cells with a low intracellular iron level required iron-saturated transferrin for further growth and apotransferrin + deferoxamine was ineffective.	Iron	70-74	serotransferrin	Bos taurus	85-96
2721585-8	1989	The results suggest that transferrin can act as a cell growth factor only in the iron-saturated form.	Iron	81-85	serotransferrin	Bos taurus	25-36
2739349-0	1989	Occupancy of the iron-binding sites of human transferrin in sera obtained from different anatomical sites.	Iron	17-21	transferrin	Homo sapiens	45-56
2705439-4	1989	Although the hemochromatic macrophages had a somewhat lower affinity for diferric transferrin iron than normal macrophages (Kd 4.7 x 10(-8) M vs. 3.0 x 10(-8)M) the difference did not reach statistical significance (t = 2.01013; P less than 0.07).	Iron	94-98	transferrin	Homo sapiens	82-93
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	160-164	transferrin	Homo sapiens	166-168
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	169-171	transferrin	Homo sapiens	56-67
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	169-171	transferrin	Homo sapiens	69-71
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	169-171	transferrin	Homo sapiens	148-159
2470252-1	1989	The authors previously have reported on the presence of transferrin (TF) receptors on liver endothelial cells and have shown that hepatic uptake of transferrin-iron (TF-Fe) complexes in the liver is mediated by the endothelium.	Iron	169-171	transferrin	Homo sapiens	166-168
2470252-3	1989	Transport of TF-Fe from endothelial cell to hepatocyte was studied in mixed cell suspensions in which radiolabeled TF-Fe complexes were incubated at 37 degrees C with the two cell populations purified and then mixed in equal ratios.	Iron	16-18	transferrin	Homo sapiens	13-15
2708361-2	1989	Transferrin (Tf), the iron transport protein of vertebrate serum, is mainly synthesized in the liver.	Iron	22-26	transferrin	Homo sapiens	13-15
2741175-2	1989	Combinations of iron loading with other stress-inducing treatments (exhaustive physical exercise and hyperoxia) caused marked decreases in cytochrome P-450 content.	Iron	16-20	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	139-155
2741175-1	1989	Iron loading was associated with development of oxidative stress, viz, decrease in tocopherol content and an increase in amount of lipid peroxidation products but only slight, if any, decrease in cytochrome P-450 content.	Iron	0-4	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	196-212
2730581-0	1989	Effect of ATP depletion and temperature on the transferrin-mediated uptake and release of iron by BeWo choriocarcinoma cells.	Iron	90-94	transferrin	Homo sapiens	47-58
2730581-1	1989	We have recently described the transferrin-mediated uptake and release of iron by BeWo cells [van der Ende, du Maine, Simmons, Schwartz & Strous (1987) J. Biol.	Iron	74-78	transferrin	Homo sapiens	31-42
2496141-0	1989	Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.	Iron	181-185	interferon gamma	Homo sapiens	0-16
2719707-3	1989	The results support the idea that myoglobin is liquid-like at physiological temperatures, but is glass-like below about 250 K. The equilibrium position of the iron atom in the heme group in the electronic excited state was estimated from the determined parameter values.	Iron	159-163	myoglobin	Equus caballus	34-43
2702636-2	1989	The mechanism of transferrin and iron uptake was the same in the transformed cells as in normal myogenic cells and involved receptor-mediated endocytosis of transferrin.	Iron	33-37	transferrin	Homo sapiens	157-168
2711187-1	1989	Iron-responsive elements (IREs) are RNA motifs that have been identified within the 5" untranslated region of ferritin messenger RNA and the 3" untranslated region of transferrin receptor mRNA.	Iron	0-4	transferrin	Homo sapiens	167-178
2711187-2	1989	A single IRE mediates iron-dependent control of ferritin translation, whereas multiple IREs are found in the region of the transferrin receptor mRNA responsible for iron-dependent control of mRNA stability.	Iron	165-169	transferrin	Homo sapiens	123-134
2719657-3	1989	Purified rat transferrin was radiolabelled either with 125I (protein moiety) or with 3H (sialyl residues), and subsequently saturated with iron.	Iron	139-143	transferrin	Rattus norvegicus	13-24
2702636-5	1989	Despite this, the rate of iron uptake increased by only 20% in the transformed cells due to less efficient cycling of the transferrin receptors and less efficient release of iron from transferrin to intracellular sites.	Iron	26-30	transferrin	Homo sapiens	122-133
2702636-5	1989	Despite this, the rate of iron uptake increased by only 20% in the transformed cells due to less efficient cycling of the transferrin receptors and less efficient release of iron from transferrin to intracellular sites.	Iron	26-30	transferrin	Homo sapiens	184-195
2702636-5	1989	Despite this, the rate of iron uptake increased by only 20% in the transformed cells due to less efficient cycling of the transferrin receptors and less efficient release of iron from transferrin to intracellular sites.	Iron	174-178	transferrin	Homo sapiens	184-195
2702636-6	1989	Some internalized iron was released from the transformed cells still bound to transferrin.	Iron	18-22	transferrin	Homo sapiens	78-89
2468292-12	1989	According to the same technique, intraperitoneally administered diferric transferrin retained its iron during passage into the circulation.	Iron	98-102	transferrin	Rattus norvegicus	73-84
2767366-3	1989	In beta-thalassemic subjects the serum ferritin levels have been found in the normal range and this seems to be correlated with an adequate and ready iron supply by protein transferrin to hyperplastic bone marrow.	Iron	150-154	transferrin	Homo sapiens	173-184
2660931-3	1989	Faecal iron, derived from the bile, appears to arise from intracellular chelation of a transit iron pool related to hepatocyte iron stores, whereas urine iron may be derived from iron capable of exchanging with plasma transferrin at cell membranes of both hepatocytes and macrophages.	Iron	7-11	transferrin	Homo sapiens	218-229
2506153-1	1989	Cellular expression of the transferrin receptor is determined by the proliferative state and iron requirements of the cell.	Iron	93-97	transferrin	Homo sapiens	27-38
2767366-4	1989	The higher urinary iron values in normal male subjects can be explained in this way: a large iron supply from the transferrin to the thalassemic erythroid cells limits the contribution from this protein to the urinary iron.	Iron	19-23	transferrin	Homo sapiens	114-125
2767366-4	1989	The higher urinary iron values in normal male subjects can be explained in this way: a large iron supply from the transferrin to the thalassemic erythroid cells limits the contribution from this protein to the urinary iron.	Iron	93-97	transferrin	Homo sapiens	114-125
2767366-4	1989	The higher urinary iron values in normal male subjects can be explained in this way: a large iron supply from the transferrin to the thalassemic erythroid cells limits the contribution from this protein to the urinary iron.	Iron	93-97	transferrin	Homo sapiens	114-125
2660049-5	1989	The cellular uptake of iron into the erythropoietic precursors depends on the presence of iron-saturated transferrin.	Iron	23-27	transferrin	Homo sapiens	105-116
2715565-8	1989	Hepatotoxicity was enhanced by iron overload only in the case of CCl4-treated, Fe-fumarate-fed rats.	Iron	31-35	C-C motif chemokine ligand 4	Rattus norvegicus	65-69
2732309-0	1989	[Detection of transferrin in the digestive juices of rat and its possible role in iron absorption from the small intestine].	Iron	82-86	transferrin	Rattus norvegicus	14-25
2732309-1	1989	Presence of transferrin in digestive juices and its possible role in iron absorption of rats were examined.	Iron	69-73	transferrin	Rattus norvegicus	12-23
2732309-3	1989	Transferrin concentration in pancreas juice was the highest (approximately 0.28 mg/ml) in the collected digestive juices and the concentration in iron deficient rats was 4 times higher than that of normal rats.	Iron	146-150	transferrin	Rattus norvegicus	0-11
2732309-4	1989	The iron saturation rate of transferrin in pancreas juice was approximately 40%.	Iron	4-8	transferrin	Rattus norvegicus	28-39
2732309-5	1989	The participation of transferrin in iron absorption was investigated by the absorption through the intestinal segment of rats, into which 59Fe labeled diferric transferrin was injected.	Iron	36-40	transferrin	Rattus norvegicus	21-32
2732309-8	1989	Iron absorption from diferric transferrin in the duodenal segment was inhibited by 1 mM monodansylcadaverine, the inhibitor of endocytosis, or addition of 20 times the normal amounts of nonradioactive transferrin in the test material.	Iron	0-4	transferrin	Rattus norvegicus	30-41
2732309-8	1989	Iron absorption from diferric transferrin in the duodenal segment was inhibited by 1 mM monodansylcadaverine, the inhibitor of endocytosis, or addition of 20 times the normal amounts of nonradioactive transferrin in the test material.	Iron	0-4	transferrin	Rattus norvegicus	201-212
2732309-9	1989	These data indicated that the process of iron absorption through diferric transferrin was not a passive phenomenon.	Iron	41-45	transferrin	Rattus norvegicus	74-85
2660049-5	1989	The cellular uptake of iron into the erythropoietic precursors depends on the presence of iron-saturated transferrin.	Iron	90-94	transferrin	Homo sapiens	105-116
2660049-6	1989	Thus, iron utilization for the hemoglobin synthesis correlates with the transferrin concentration in blood.	Iron	6-10	transferrin	Homo sapiens	72-83
2466835-0	1989	Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis.	Iron	22-26	transferrin	Homo sapiens	4-15
2466835-2	1989	The nature of non-transferrin-bound iron in the plasma or serum of iron-overloaded hemochromatosis patients was studied by high performance liquid chromatography (HPLC) and high resolution nuclear magnetic resonance (NMR).	Iron	36-40	transferrin	Homo sapiens	18-29
2466835-2	1989	The nature of non-transferrin-bound iron in the plasma or serum of iron-overloaded hemochromatosis patients was studied by high performance liquid chromatography (HPLC) and high resolution nuclear magnetic resonance (NMR).	Iron	67-71	transferrin	Homo sapiens	18-29
2466835-6	1989	It is proposed that non-transferrin-bound iron in the plasma of iron-overloaded patients exists largely as complexes with citrate and possibly also as ternary iron-citrate-acetate complexes.	Iron	42-46	transferrin	Homo sapiens	24-35
2466835-6	1989	It is proposed that non-transferrin-bound iron in the plasma of iron-overloaded patients exists largely as complexes with citrate and possibly also as ternary iron-citrate-acetate complexes.	Iron	64-68	transferrin	Homo sapiens	24-35
2466835-7	1989	The presence of such complexes would account for the ability of non-transferrin-bound iron to be measurable by the bleomycin assay and for its rapid clearance from the circulation by the liver.	Iron	86-90	transferrin	Homo sapiens	68-79
2471448-3	1989	Mean levels of haemoglobin, mean corpuscular volume, serum iron, transferrin saturation and serum ferritin rose in the iron-treated group and fell in the placebo group at all ages, except under 1 year for serum ferritin, to produce significant differences between the groups by the end of the study.	Iron	119-123	transferrin	Homo sapiens	65-76
2923087-1	1989	The effect of the two major bovine milk protein fractions on the dialyzability of iron in vitro under simulated gastrointestinal conditions and on the absorption of Fe by humans was studied.	Iron	82-86	casein beta	Bos taurus	35-47
2646156-2	1989	Proliferating cells have an absolute requirement for iron, which is delivered by transferrin with subsequent intracellular transport via the transferrin receptor.	Iron	53-57	transferrin	Homo sapiens	81-92
2658733-1	1989	The known relationship between ethanol and the two main proteins of iron metabolism, transferrin and ferritin, are reviewed.	Iron	68-72	transferrin	Homo sapiens	85-96
2537143-1	1989	Gallium resembles iron with respect to transferrin (Tf) binding and cellular uptake via Tf receptors.	Iron	18-22	transferrin	Homo sapiens	39-50
2537143-2	1989	We have previously shown that transferrin-gallium (Tf-Ga) complexes interfere with the cellular incorporation of iron and inhibit the proliferation of HL60 cells.	Iron	113-117	transferrin	Homo sapiens	30-41
2543489-4	1989	The expression of transferrin- and lactoferrin-binding activity was induced by addition of ethylenediamine di-o-phenylacetic acid and reversed by excess FeCl3, indicating regulation by the level of available iron in the medium.	Iron	208-212	transferrin	Homo sapiens	18-29
2784116-8	1989	Although cachectin/TNF-IL 1-, or endotoxin treatment resulted in similar hypoferremia and shortened plasma iron half-life, endotoxin or cachectin/TNF treatment (but not IL 1) significantly reduced the incorporation of plasma 59Fe into newly synthesized RBCs.	Iron	107-111	tumor necrosis factor	Homo sapiens	9-18
2657605-1	1989	Transferrin structure, metabolism and physiological functions (iron transport, activation of cellular growth, bacteriostatic effect) are described with reference to the last informations available from the literature.	Iron	63-67	transferrin	Homo sapiens	0-11
2784116-8	1989	Although cachectin/TNF-IL 1-, or endotoxin treatment resulted in similar hypoferremia and shortened plasma iron half-life, endotoxin or cachectin/TNF treatment (but not IL 1) significantly reduced the incorporation of plasma 59Fe into newly synthesized RBCs.	Iron	107-111	tumor necrosis factor	Homo sapiens	19-22
2926242-3	1989	Iron 55-labeled rat transferrin was injected at the same time as the 59Fe-labeled compound, and storage iron release was calculated from the cumulative incorporation of the two isotopes in the red cell mass over 2 weeks.	Iron	0-4	transferrin	Rattus norvegicus	20-31
2926242-7	1989	A strong correlation between hepatocyte iron release and plasma transferrin receptor levels was observed (p less than 0.001), suggesting that plasma transferrin receptors could mediate the regulation of hepatocyte iron mobilization in rats.	Iron	40-44	transferrin	Rattus norvegicus	64-75
2926242-7	1989	A strong correlation between hepatocyte iron release and plasma transferrin receptor levels was observed (p less than 0.001), suggesting that plasma transferrin receptors could mediate the regulation of hepatocyte iron mobilization in rats.	Iron	40-44	transferrin	Rattus norvegicus	149-160
2926242-7	1989	A strong correlation between hepatocyte iron release and plasma transferrin receptor levels was observed (p less than 0.001), suggesting that plasma transferrin receptors could mediate the regulation of hepatocyte iron mobilization in rats.	Iron	214-218	transferrin	Rattus norvegicus	64-75
2926242-7	1989	A strong correlation between hepatocyte iron release and plasma transferrin receptor levels was observed (p less than 0.001), suggesting that plasma transferrin receptors could mediate the regulation of hepatocyte iron mobilization in rats.	Iron	214-218	transferrin	Rattus norvegicus	149-160
2921643-2	1989	Compared to ad libitum fed controls, MT-I concentrations in the blood cells of the iron-deficient rats were higher, whereas concentrations in pair-fed control rats were lower.	Iron	83-87	metallothionein 1	Rattus norvegicus	37-41
2912502-2	1989	Uptake of iron from ferritin by the cells is partially inhibited by including apotransferrin in the culture medium, but not by inclusion of diferric transferrin.	Iron	10-14	transferrin	Rattus norvegicus	81-92
2748978-0	1989	Vitellogenin-iron and hemoglobin synthesis in avian reticulocytes.	Iron	13-17	putative uncharacterized protein LOC400499	Homo sapiens	0-12
2748978-1	1989	Avian vitellogenin has been studied as an iron carrier for hemoglobin synthesis by reticulocytes.	Iron	42-46	putative uncharacterized protein LOC400499	Homo sapiens	6-18
2748978-2	1989	The Fe-vitellogenin uptake by the immature red cells is progressive with time, following an unspecific iron uptake process.	Iron	103-107	putative uncharacterized protein LOC400499	Homo sapiens	7-19
2748978-3	1989	The iron uptake from Fe-vitellogenin was in proportion to the immature red cells present and the radioactive iron was found in the hemoglobin synthesized by these cells.	Iron	4-8	putative uncharacterized protein LOC400499	Homo sapiens	24-36
2748978-4	1989	These results open up the possibility of assigning a secondary role to the Fe-vitellogenin in the avian erythropoiesis, added to the classical iron transport function for egg production.	Iron	143-147	putative uncharacterized protein LOC400499	Homo sapiens	78-90
2541755-0	1989	Effect of the hinge protein on the heme iron site of cytochrome c1.	Iron	40-44	cytochrome c1	Homo sapiens	53-66
2541755-6	1989	(1987) Biochemistry 26, 1955-1961] demonstrates that the hinge protein exerts a rather pronounced effect on the heme environment of the cytochrome c1: a conformational change occurs within a radius of approximately 5 A from the heme iron in cytochrome c1 when the hinge protein is bound to cytochrome c1.	Iron	120-124	cytochrome c1	Homo sapiens	136-149
2541755-6	1989	(1987) Biochemistry 26, 1955-1961] demonstrates that the hinge protein exerts a rather pronounced effect on the heme environment of the cytochrome c1: a conformational change occurs within a radius of approximately 5 A from the heme iron in cytochrome c1 when the hinge protein is bound to cytochrome c1.	Iron	120-124	cytochrome c1	Homo sapiens	241-254
2541755-6	1989	(1987) Biochemistry 26, 1955-1961] demonstrates that the hinge protein exerts a rather pronounced effect on the heme environment of the cytochrome c1: a conformational change occurs within a radius of approximately 5 A from the heme iron in cytochrome c1 when the hinge protein is bound to cytochrome c1.	Iron	120-124	cytochrome c1	Homo sapiens	241-254
2538353-2	1989	The elastase-inhibitory activity of alpha 1-antiproteinase is inactivated by hydroxyl radicals (.OH) generated by pulse radiolysis or by reaction of iron ions with H2O2 in the presence of superoxide or ascorbate.	Iron	149-153	serpin family A member 1	Homo sapiens	36-58
2537062-3	1989	Catalytic activity is decreased by pretreatment of silicates with the iron chelators deferoxamine or transferrin.	Iron	70-74	transferrin	Homo sapiens	101-112
2492522-13	1989	Rhodanese, in turn, serves as a converter enzyme which directly alters the rate of the respiratory chain and, thus, ATP production by the reversible sulfuration of key iron-sulfur centers.	Iron	168-172	thiosulfate sulfurtransferase	Bos taurus	0-9
2914926-0	1989	19F nuclear magnetic resonance as a probe of the spatial relationship between the heme iron of cytochrome P-450 and its substrate.	Iron	87-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	95-111
2914926-1	1989	The distance between the heme iron of ferrous cytochrome P-450-CAM and a fluorine label attached to the 9-methyl carbon of its substrate, (1R)-(+)-camphor, has been determined using 19F NMR.	Iron	30-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-62
2709674-0	1989	Iron status in patients receiving erythropoietin for dialysis-associated anemia.	Iron	0-4	erythropoietin	Homo sapiens	34-48
2492027-9	1989	It is suggested that this effect of lactic acid is mediated by increased dissociation of catalytic iron from proteins of the transferrin type.	Iron	99-103	transferrin	Rattus norvegicus	125-136
2646506-6	1989	With increasing hepatocellular iron deposition, the proportion of cases with absent transferrin receptor immunoreactivity increased.	Iron	31-35	transferrin	Homo sapiens	84-95
2646506-7	1989	This supports the previously reported disappearance of hepatocellular transferrin receptor expression in primary hemochromatosis cases with severe iron deposition.	Iron	147-151	transferrin	Homo sapiens	70-81
2646506-8	1989	However, the transferrin receptor negative cases included four specimens in which Kupffer cell iron deposition clearly exceeded hepatocyte iron load.	Iron	95-99	transferrin	Homo sapiens	13-24
2646506-8	1989	However, the transferrin receptor negative cases included four specimens in which Kupffer cell iron deposition clearly exceeded hepatocyte iron load.	Iron	139-143	transferrin	Homo sapiens	13-24
2709674-1	1989	Adequate body iron stores are crucial to assuring rapid and complete response to recombinant human erythropoietin (rHuEPO).	Iron	14-18	erythropoietin	Homo sapiens	99-113
2646506-9	1989	This finding suggests that in addition to hepatocellular iron load other factors may regulate the expression of parenchymal transferrin receptors in iron overload diseases.	Iron	57-61	transferrin	Homo sapiens	124-135
2646506-9	1989	This finding suggests that in addition to hepatocellular iron load other factors may regulate the expression of parenchymal transferrin receptors in iron overload diseases.	Iron	149-153	transferrin	Homo sapiens	124-135
2914136-0	1989	Human platelets mediate iron release from transferrin by adenine nucleotide-dependent and -independent mechanisms.	Iron	24-28	transferrin	Homo sapiens	42-53
2909248-3	1989	According to the results of the amino acid sequence, iron binding ability and physicochemical properties, we identified the growth-promoting factor as horse serum transferrin.	Iron	53-57	transferrin	Homo sapiens	163-174
2562689-3	1989	Estimation of TIBC reflects the quantity of transferrin which is the iron carrier in serum.	Iron	69-73	transferrin	Homo sapiens	44-55
2485582-1	1989	The structure and properties of the iron-binding proteins transferrin, lactoferrin and transferrin are reviewed.	Iron	36-40	transferrin	Homo sapiens	58-69
2485582-1	1989	The structure and properties of the iron-binding proteins transferrin, lactoferrin and transferrin are reviewed.	Iron	36-40	transferrin	Homo sapiens	87-98
2485582-2	1989	Transferrin and lactoferrin are structurally similar, consisting of a single polypeptide chain and reversibly binding two iron atoms per molecule.	Iron	122-126	transferrin	Homo sapiens	0-11
2914136-1	1989	We assessed the ability of platelet sonicates and mediators secreted by unstimulated and thrombin-stimulated platelets to facilitate the release of iron from transferrin.	Iron	148-152	coagulation factor II, thrombin	Homo sapiens	89-97
2914136-1	1989	We assessed the ability of platelet sonicates and mediators secreted by unstimulated and thrombin-stimulated platelets to facilitate the release of iron from transferrin.	Iron	148-152	transferrin	Homo sapiens	158-169
2914136-2	1989	Platelet sonicates and platelet conditioned media potentiated the release of iron from transferrin.	Iron	77-81	transferrin	Homo sapiens	87-98
2914136-4	1989	Conditioned media from thrombin-stimulated platelets was more effective in mediating the release of iron from transferrin than was conditioned media from unstimulated cells.	Iron	100-104	coagulation factor II, thrombin	Homo sapiens	23-31
2914136-4	1989	Conditioned media from thrombin-stimulated platelets was more effective in mediating the release of iron from transferrin than was conditioned media from unstimulated cells.	Iron	100-104	transferrin	Homo sapiens	110-121
2914136-5	1989	The rate of iron released from transferrin following addition of ATP and ADP in amounts equivalent to that present in platelet conditioned media was significantly less than the rate of iron released following the addition of conditioned media from platelets.	Iron	12-16	transferrin	Homo sapiens	31-42
2914136-6	1989	Depletion of ATP and ADP in platelet conditioned media by incubation with apyrase only partially inhibited their ability to enhance the rate of iron release from transferrin.	Iron	144-148	transferrin	Homo sapiens	162-173
2914136-7	1989	These observations indicate that platelets enhance the release of iron from transferrin by adenine nucleotide-dependent and -independent mechanisms.	Iron	66-70	transferrin	Homo sapiens	76-87
2914136-8	1989	These observations are consistent with the hypothesis that platelets promote oxidant-induced tissue injury at sights of inflammation secondary to their ability to enhance the local release of iron from transferrin.	Iron	192-196	transferrin	Homo sapiens	202-213
2752211-0	1989	Effects of iron overload on transferrin secretion by cultured fetal rat hepatocytes.	Iron	11-15	transferrin	Rattus norvegicus	28-39
2752211-4	1989	The present data demonstrate that iron overload decreases transferrin secretion; this effect appears not to be specific, since albumin production is affected in a similar manner.	Iron	34-38	transferrin	Rattus norvegicus	58-69
2752211-6	1989	Since the corresponding mRNA is unaffected, it may be postulated that iron overload decreases transferrin secretion at some post-transcriptional level.	Iron	70-74	transferrin	Rattus norvegicus	94-105
2642019-0	1989	Further evaluation of the biphasic kinetics of iron removal from transferrin by 3,4-LICAMS.	Iron	47-51	transferrin	Homo sapiens	65-76
2490073-0	1989	Iron release from transferrin induced by mixed ligand complexes of copper(II).	Iron	0-4	transferrin	Homo sapiens	18-29
2490073-5	1989	The active copper(II) complexes are postulated to be models of membrane components that could liberate iron from transferrin succeeding its uptake at the receptor sites of cells.	Iron	103-107	transferrin	Homo sapiens	113-124
2570667-8	1989	Vitellogenin purified from the plasma of laying hens is a metalloprotein which upon analysis was found to contain 0.54, 0.09 and 0.72 micrograms of zinc, copper and iron, respectively, per mg of protein.	Iron	165-169	vitellogenin 2	Gallus gallus	0-12
2462936-8	1989	These data suggest that cells with a high iron requirement synthesize two forms of transferrin receptor, possibly by means of differential mRNA splicing or by posttranslational modification of the transferrin receptor.	Iron	42-46	transferrin	Homo sapiens	83-94
2485582-4	1989	Transferrin functions mainly as a donor of iron to cells, but there is no established iron-transport role for lactoferrin.	Iron	43-47	transferrin	Homo sapiens	0-11
2485589-3	1989	The need to conserve body iron stores has closely evolved with an essential requirement for antioxidant protection and, several "acute-phase" proteins involved in iron metabolism such as caeruloplasmin, haptoglobins and haemopexin in collaboration with the iron binding proteins transferrin and lactoferrin contribute to our defense against oxidative damage.	Iron	26-30	transferrin	Homo sapiens	279-290
2485589-3	1989	The need to conserve body iron stores has closely evolved with an essential requirement for antioxidant protection and, several "acute-phase" proteins involved in iron metabolism such as caeruloplasmin, haptoglobins and haemopexin in collaboration with the iron binding proteins transferrin and lactoferrin contribute to our defense against oxidative damage.	Iron	163-167	transferrin	Homo sapiens	279-290
2485589-3	1989	The need to conserve body iron stores has closely evolved with an essential requirement for antioxidant protection and, several "acute-phase" proteins involved in iron metabolism such as caeruloplasmin, haptoglobins and haemopexin in collaboration with the iron binding proteins transferrin and lactoferrin contribute to our defense against oxidative damage.	Iron	163-167	transferrin	Homo sapiens	279-290
2665999-4	1989	Transferrin is the iron transport protein of plasma, which can bind 2 atoms of iron per protein molecule, and which interacts with various cell types to provide them with the iron required for their metabolic and proliferative processes.	Iron	19-23	transferrin	Homo sapiens	0-11
2665999-4	1989	Transferrin is the iron transport protein of plasma, which can bind 2 atoms of iron per protein molecule, and which interacts with various cell types to provide them with the iron required for their metabolic and proliferative processes.	Iron	79-83	transferrin	Homo sapiens	0-11
2665999-4	1989	Transferrin is the iron transport protein of plasma, which can bind 2 atoms of iron per protein molecule, and which interacts with various cell types to provide them with the iron required for their metabolic and proliferative processes.	Iron	79-83	transferrin	Homo sapiens	0-11
2665999-6	1989	In erythroid cells as well as certain laboratory cell lines, the removal of iron from transferrin apparently proceeds via the receptor-mediated endocytosis process.	Iron	76-80	transferrin	Homo sapiens	86-97
2666983-4	1989	We found that beta-cell proliferation is stimulated by iron-saturated transferrin, interleukin-1-alpha, fetal calf serum, and glucose.	Iron	55-59	transferrin	Rattus norvegicus	70-81
2667838-9	1989	It is currently accepted that a transferrin, whose levels increase in iron deficiency, enters the intestinal lumen from the liver via bile, where it may sequester iron and bring it into the cells by the process of endocytosis.	Iron	70-74	transferrin	Homo sapiens	32-43
2714234-5	1989	Iron-free transferrin and transferrin samples of known iron content were examined.	Iron	0-4	transferrin	Homo sapiens	10-21
2714234-7	1989	By monitoring the focused protein zones at both 280 and 460 nm the molecular forms of transferrin (iron-free, monoferric and differic complexes) can easily be identified.	Iron	99-103	transferrin	Homo sapiens	86-97
2714234-9	1989	We observed that chelating agents (e.g., carrier ampholytes, nitrilotriacetate) may release iron from microsyringes having metal pistons causing the formation of iron-transferrin complexes.	Iron	92-96	transferrin	Homo sapiens	167-178
2555273-4	1989	During this redox cycling membrane-bound nonheme iron undergoes superoxide dismutase- and catalase-insensitive reductive release.	Iron	49-53	catalase	Homo sapiens	90-98
2555273-5	1989	Membrane iron mobilization triggers lipid peroxidation, which is markedly enhanced by simultaneous addition of superoxide dismutase and catalase.	Iron	9-13	catalase	Homo sapiens	136-144
2642288-3	1989	Using immunohistochemical techniques, we have examined the effects of therapeutic changes in liver iron stores on the expression of the hepatic transferrin receptor in hereditary hemochromatosis.	Iron	99-103	transferrin	Homo sapiens	144-155
2642288-6	1989	In contrast, hepatocyte transferrin receptor was detected in seven patients in whom hepatic iron stores were markedly depleted by venesection (hepatic ferritin mean = 0.32 microgram per mg protein, range = 0.16 to 0.53 microgram per mg protein; hepatic iron mean = 0.98 microgram per mg protein, range = 0.3 to 2.1 micrograms per mg protein).	Iron	92-96	transferrin	Homo sapiens	24-35
2642288-6	1989	In contrast, hepatocyte transferrin receptor was detected in seven patients in whom hepatic iron stores were markedly depleted by venesection (hepatic ferritin mean = 0.32 microgram per mg protein, range = 0.16 to 0.53 microgram per mg protein; hepatic iron mean = 0.98 microgram per mg protein, range = 0.3 to 2.1 micrograms per mg protein).	Iron	253-257	transferrin	Homo sapiens	24-35
2642288-7	1989	Sequential data from one patient confirmed the reexpression of receptor in response to therapeutic iron depletion, whereas data from another patient studied during treatment illustrated a reciprocal relationship between liver tissue distribution of iron and expression of transferrin receptor.	Iron	249-253	transferrin	Homo sapiens	272-283
2708811-1	1989	Thromboxane synthase is a cytochrome P-450-like enzyme requiring an iron-centered oxygen attack of the prostaglandin endoperoxide substrate (PGH2) for subsequent thromboxane A2 (TxA2) formation.	Iron	68-72	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	26-42
2474701-2	1989	Normal values of serum iron, serum transferrin and ferritin, and of transferrin saturation with iron in newborns and infants aged under one are presented.	Iron	96-100	transferrin	Homo sapiens	68-79
2558984-6	1989	Under conditions that minimize .OH production (absence of EDTA, iron) ethanol was oxidized by a cytochrome P-450-dependent process independent of reactive oxygen intermediates.	Iron	64-68	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	96-112
2472309-2	1989	Transferrin (TF) is the major transport protein involved in human iron metabolism.	Iron	66-70	transferrin	Homo sapiens	0-11
2472309-2	1989	Transferrin (TF) is the major transport protein involved in human iron metabolism.	Iron	66-70	transferrin	Homo sapiens	13-15
2472309-7	1989	Vitreal TF as a major iron acceptor probably has a protective function, but its interaction with macrophages and its growth-promoting activity may subsequently stimulate the proliferation of fibroblasts and retinal pigment epithelial cells.	Iron	22-26	transferrin	Homo sapiens	8-10
18925233-7	1989	Results correlated closely with those obtained using radial immunodiffusion (RID) (r = 0.942) and total iron-binding capacity (r = 0.954)for 90 determinations.Transferrin measurement by immunoturbidimetry on the Kone Progress emerges as a well-suited, rapid and inexpensive alternative to other time-consuming (RID) and sophisticated (laser immunonephelemeter) techniques.	Iron	104-108	transferrin	Homo sapiens	159-170
2927254-1	1989	The binding of iron to transferrin was studied by loading iron (III) onto apotransferrin in a chloride and a nitrilotriacetate form.	Iron	15-19	transferrin	Homo sapiens	23-34
2927254-2	1989	When magnesium was added, a marked increase occurred in both the rate of iron binding and the maximum level of iron loaded on transferrin utilizing either iron salt.	Iron	111-115	transferrin	Homo sapiens	126-137
2489896-11	1989	3) We observed positive effects on the induction of SOD activity and proliferation by the supplementation of iron, managnese, or both in the metal chlated medium under aerobic condition.	Iron	109-113	superoxide dismutase 1	Homo sapiens	52-55
2576881-7	1989	Utilizing a model metal-catalyzed oxidation system (ascorbate/iron/oxygen) studies on bacterial glutamine synthetase revealed several functional and structural changes.	Iron	62-66	glutamate-ammonia ligase	Homo sapiens	96-116
2489896-12	1989	Based on the above results, we found that iron and manganese were essential metals for SOD activity induction.	Iron	42-46	superoxide dismutase 1	Homo sapiens	87-90
2852009-0	1988	The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin.	Iron	37-41	transferrin	Homo sapiens	59-70
3058232-2	1988	We have previously shown that transferrin-gallium (Tf-Ga) inhibits cellular iron incorporation.	Iron	76-80	transferrin	Homo sapiens	30-41
2974803-0	1988	Domain preference in iron removal from human transferrin by the bacterial siderophores aerobactin and enterochelin.	Iron	21-25	transferrin	Homo sapiens	45-56
2974803-1	1988	The ability of the siderophores aerobactin and enterochelin to remove iron from transferrin is reported.	Iron	70-74	transferrin	Homo sapiens	80-91
2974803-2	1988	Aerobactin removes iron from both high-affinity sites on the transferrin molecule, but shows a marked preference for the C-terminal site.	Iron	19-23	transferrin	Homo sapiens	61-72
3189316-6	1988	When the transferrin receptor was blocked by the prior injection of 50 mg human diferric transferrin, iron uptake from all transferrins was delayed to such an extent that uptake through both receptors seemed to be affected.	Iron	102-106	transferrin	Homo sapiens	9-20
3189316-6	1988	When the transferrin receptor was blocked by the prior injection of 50 mg human diferric transferrin, iron uptake from all transferrins was delayed to such an extent that uptake through both receptors seemed to be affected.	Iron	102-106	transferrin	Homo sapiens	89-100
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	Iron	47-51	transferrin	Homo sapiens	35-46
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	Iron	47-51	transferrin	Homo sapiens	97-108
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	Iron	47-51	transferrin	Homo sapiens	97-108
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	Iron	253-257	transferrin	Homo sapiens	35-46
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	Iron	253-257	transferrin	Homo sapiens	35-46
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	Iron	253-257	transferrin	Homo sapiens	35-46
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	Iron	253-257	transferrin	Homo sapiens	35-46
3141281-0	1988	Loss of transferrin receptor activity in Neisseria meningitidis correlates with inability to use transferrin as an iron source.	Iron	115-119	transferrin	Homo sapiens	8-19
3066739-6	1988	Interestingly, iron uptake was also detected in the presence of transferrin, despite the minimal amounts of transferrin acquired by live treponemes.	Iron	15-19	transferrin	Homo sapiens	64-75
3141281-1	1988	Although Neisseria meningitidis does not produce siderophores, it is able to obtain iron from human transferrin.	Iron	84-88	transferrin	Homo sapiens	100-111
3141281-7	1988	A meningococcal transformant specifically unable to utilize transferrin as an iron source had decreased transferrin receptor activity.	Iron	78-82	transferrin	Homo sapiens	104-115
3141281-8	1988	These data are consistent with the hypothesis that receptor-mediated binding of transferrin is a rate-limiting step in meningococcal iron uptake from transferrin.	Iron	133-137	transferrin	Homo sapiens	80-91
3141281-8	1988	These data are consistent with the hypothesis that receptor-mediated binding of transferrin is a rate-limiting step in meningococcal iron uptake from transferrin.	Iron	133-137	transferrin	Homo sapiens	150-161
3252892-4	1988	The most strongly associated interaction is the chelation of iron by transferrin, with an association constant of approximately 10(21); tyrosines, histidines, and sometimes aspartate are involved.	Iron	61-65	transferrin	Homo sapiens	69-80
3182815-0	1988	Hepatocytes and reticulocytes have different mechanisms for the uptake of iron from transferrin.	Iron	74-78	transferrin	Rattus norvegicus	84-95
3182866-2	1988	22-ABC binds to purified cytochrome P-450 3c producing a type II spectral change reflecting the coordination of the amine with the heme iron of the protein.	Iron	136-140	cytochrome P450 3A6	Oryctolagus cuniculus	25-44
3229129-3	1988	In sections, stained with colloidal iron, regions with rds/rds photoreceptor layer, characteristically lacking the outer segments, showed more intense staining of the interphotoreceptor matrix, while regions with normal receptor outer segments showed less intense staining of the matrix.	Iron	36-40	peripherin 2	Mus musculus	55-58
3229129-3	1988	In sections, stained with colloidal iron, regions with rds/rds photoreceptor layer, characteristically lacking the outer segments, showed more intense staining of the interphotoreceptor matrix, while regions with normal receptor outer segments showed less intense staining of the matrix.	Iron	36-40	peripherin 2	Mus musculus	59-62
3182815-1	1988	The uptake of iron from transferrin by isolated rat hepatocytes and rat reticulocytes has been compared.	Iron	14-18	transferrin	Rattus norvegicus	24-35
3182815-5	1988	2) Hepatocyte plasma membrane NADH:ferricyanide oxidoreductase activity and uptake of iron from transferrin are stimulated by low oxygen concentration and inhibited by iodoacetate.	Iron	86-90	transferrin	Rattus norvegicus	96-107
3182815-7	1988	3) Ferricyanide inhibits the uptake of iron from transferrin by hepatocytes, but has no effect on iron uptake by reticulocytes.	Iron	39-43	transferrin	Rattus norvegicus	49-60
3188034-7	1988	The iron chelator, desferrioxamine, and dithiothreitol (DTT), which protected the cells from t-BH toxicity, also prevented the sustained elevation of cytosolic Ca2+.	Iron	4-8	carbonic anhydrase 2	Rattus norvegicus	160-163
3182815-12	1988	The results are compatible with hepatocyte uptake of iron from transferrin by a reductive process at the cell surface and reticulocyte iron uptake by receptor-mediated endocytosis.	Iron	53-57	transferrin	Rattus norvegicus	63-74
2850162-5	1988	Pretreatment of the cells with the weak base primaquine had no influence on this distribution while at the same time uptake of iron via the transferrin receptor was inhibited.	Iron	127-131	transferrin	Rattus norvegicus	140-151
2853215-0	1988	Photoexcitation of the methionine-iron bond in iron(III) cytochrome c: bimolecular reaction with NADH.	Iron	34-38	cytochrome c, somatic	Homo sapiens	57-69
3169492-6	1988	In normal rats, DFO injections also significantly blocked absorption of inorganic iron and transferrin iron.	Iron	103-107	transferrin	Rattus norvegicus	91-102
2853215-0	1988	Photoexcitation of the methionine-iron bond in iron(III) cytochrome c: bimolecular reaction with NADH.	Iron	47-51	cytochrome c, somatic	Homo sapiens	57-69
2853215-1	1988	When iron(III) cytochrome c aqueous solutions containing NADH are irradiated with polychromatic light (wavelength greater than 280 nm), iron(II) cytochrome c and NAD+ in the stoichiometric ratio 2/1 are observed to be the principal reaction products, independently of the presence of oxygen; in addition, a minor process due to direct photodegradation of the nucleotide is observed.	Iron	5-9	cytochrome c, somatic	Homo sapiens	15-27
2853215-1	1988	When iron(III) cytochrome c aqueous solutions containing NADH are irradiated with polychromatic light (wavelength greater than 280 nm), iron(II) cytochrome c and NAD+ in the stoichiometric ratio 2/1 are observed to be the principal reaction products, independently of the presence of oxygen; in addition, a minor process due to direct photodegradation of the nucleotide is observed.	Iron	5-9	cytochrome c, somatic	Homo sapiens	145-157
2853215-1	1988	When iron(III) cytochrome c aqueous solutions containing NADH are irradiated with polychromatic light (wavelength greater than 280 nm), iron(II) cytochrome c and NAD+ in the stoichiometric ratio 2/1 are observed to be the principal reaction products, independently of the presence of oxygen; in addition, a minor process due to direct photodegradation of the nucleotide is observed.	Iron	136-140	cytochrome c, somatic	Homo sapiens	15-27
2853215-1	1988	When iron(III) cytochrome c aqueous solutions containing NADH are irradiated with polychromatic light (wavelength greater than 280 nm), iron(II) cytochrome c and NAD+ in the stoichiometric ratio 2/1 are observed to be the principal reaction products, independently of the presence of oxygen; in addition, a minor process due to direct photodegradation of the nucleotide is observed.	Iron	136-140	cytochrome c, somatic	Homo sapiens	145-157
2853215-7	1988	radical rapidly reacts with oxygen to give NAD+ and superoxide O2- anion radical which, in turn, reduces the second iron(III) cytochrome c molecule.	Iron	116-120	cytochrome c, somatic	Homo sapiens	126-138
2458783-3	1988	Even when patients had been venesected to give very low total plasma iron concentrations and high transferrin iron-binding capacity, bleomycin-detectable iron was still present at low concentrations.	Iron	110-114	transferrin	Homo sapiens	98-109
2844758-0	1988	Differences in transferrin receptor function between normal developing and transformed myogenic cells as revealed by differential effects of phorbol ester on receptor distribution and rates of iron uptake.	Iron	193-197	transferrin	Homo sapiens	15-26
3046665-2	1988	The serum transferrin contaminating mucosal preparations, even when fully saturated with iron and in the presence of proteinase inhibitors, also acquires the properties of the mucosal transferrin when the mucosa is homogenised.	Iron	89-93	transferrin	Rattus norvegicus	10-21
2458783-3	1988	Even when patients had been venesected to give very low total plasma iron concentrations and high transferrin iron-binding capacity, bleomycin-detectable iron was still present at low concentrations.	Iron	110-114	transferrin	Homo sapiens	98-109
2848510-0	1988	The binding characteristics of the cytochrome c iron.	Iron	48-52	cytochrome c, somatic	Homo sapiens	35-47
2848510-2	1988	This explains the outstanding stability of the methionine-iron bond of ferrous cytochrome c, and results from the intrinsic ability of the cytochrome c iron to delocalize its electrons into orbitals of the sixth axial ligand.	Iron	58-62	cytochrome c, somatic	Homo sapiens	79-91
2848510-2	1988	This explains the outstanding stability of the methionine-iron bond of ferrous cytochrome c, and results from the intrinsic ability of the cytochrome c iron to delocalize its electrons into orbitals of the sixth axial ligand.	Iron	58-62	cytochrome c, somatic	Homo sapiens	139-151
2848510-2	1988	This explains the outstanding stability of the methionine-iron bond of ferrous cytochrome c, and results from the intrinsic ability of the cytochrome c iron to delocalize its electrons into orbitals of the sixth axial ligand.	Iron	152-156	cytochrome c, somatic	Homo sapiens	79-91
2848510-2	1988	This explains the outstanding stability of the methionine-iron bond of ferrous cytochrome c, and results from the intrinsic ability of the cytochrome c iron to delocalize its electrons into orbitals of the sixth axial ligand.	Iron	152-156	cytochrome c, somatic	Homo sapiens	139-151
3200444-7	1988	The findings of low iron and high transferrin in the choroid plexus suggest that the plexus may secrete transferrin into the cerebrospinal fluid, thereby facilitating the translocation of iron within the neuraxis.	Iron	188-192	transferrin	Homo sapiens	34-45
3200444-7	1988	The findings of low iron and high transferrin in the choroid plexus suggest that the plexus may secrete transferrin into the cerebrospinal fluid, thereby facilitating the translocation of iron within the neuraxis.	Iron	188-192	transferrin	Homo sapiens	104-115
3200444-8	1988	Furthermore, the nonidentical distribution of ferric iron and transferrin suggests that, in the human brain, transferrin may serve other functions besides the transport of iron from extracellular fluid to cytoplasm.	Iron	53-57	transferrin	Homo sapiens	109-120
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Iron	205-209	interferon gamma	Mus musculus	12-28
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Iron	205-209	tumor necrosis factor	Mus musculus	58-79
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Iron	205-209	tumor necrosis factor	Rattus norvegicus	81-85
3196300-0	1988	Chelation of transferrin iron by desferrioxamine in K562 cells.	Iron	25-29	transferrin	Homo sapiens	13-24
3196300-2	1988	In this study we have determined whether desferrioxamine can chelate iron delivered to human leukaemic cells by the transferrin endocytic cycle.	Iron	69-73	transferrin	Homo sapiens	116-127
3196300-7	1988	In cells preloaded with desferrioxamine for 1 or 4 h the partitioning of iron during a 3 h incubation with [59Fe]transferrin was dependent upon the extracellular concentration of the chelator.	Iron	73-77	transferrin	Homo sapiens	113-124
3196300-10	1988	There was a linear increase in the total amount of intracellular [59Fe]ferrioxamine in accordance with cellular iron uptake showing that transferrin continued to cycle in the presence of high concentrations of desferrioxamine.	Iron	112-116	transferrin	Homo sapiens	137-148
3196300-11	1988	The uptake of iron and generation of ferrioxamine were markedly reduced by 5 mM-methylamine, which prevented endosome acidification and uncoupling of iron from endocytosed transferrin.	Iron	14-18	transferrin	Homo sapiens	172-183
3410547-1	1988	An 84-kilodalton outer membrane protein was expressed when Pasteurella multocida, somatic serotype 3, was grown in brain-heart infusion broth containing the iron chelator dipyridyl but not in brain-heart infusion broth alone.	Iron	157-161	TolC family protein	Pasteurella multocida	17-39
3410854-5	1988	The sequence displays a high degree of homology to human ferritin H, and includes a portion of the iron-responsive element conserved in chick, frog, and human ferritin.	Iron	99-103	ferritin mitochondrial	Mus musculus	57-67
3410854-9	1988	These findings suggest a novel role for TNF in iron metabolism.	Iron	47-51	tumor necrosis factor	Mus musculus	40-43
3147711-5	1988	Recent X-ray crystallography studies of human lactotransferrin have partially confirmed the above-mentioned predicted data and have brought invaluable information about the nature of the ligands and the conformation of the iron-binding site.	Iron	223-227	lactotransferrin	Homo sapiens	46-62
3243256-1	1988	The heterogeneity of human transferrin results from (i) differences in iron content, (ii) genetic polymorphism and (iii) differences in the carbohydrate moiety.	Iron	71-75	transferrin	Homo sapiens	27-38
3177366-0	1988	Effect of ferrous and ferric chelators on transferrin-iron-macrophage interactions.	Iron	54-58	transferrin	Homo sapiens	42-53
3177366-1	1988	A study was done to evaluate the effect of ferrous and ferric chelators on the interaction between transferrin-iron and cultured human blood monocytes.	Iron	111-115	transferrin	Homo sapiens	99-110
3177366-4	1988	Chase experiments and prolonged incubation studies suggested that the chelator prevented the iron released from transferrin from negotiating the unit membrane.	Iron	93-97	transferrin	Homo sapiens	112-123
3177366-7	1988	These findings are compatible with the hypothesis that transferrin-iron is reduced to the ferrous state during its uptake by the culture human blood monocyte.	Iron	67-71	transferrin	Homo sapiens	55-66
3415986-6	1988	At a low incubation concentration of transferrin (0.5 microM), the presence of both rat albumin and the antibody decreased the rate of iron uptake by the cells to about 15% of the value found in their absence, but to only 40% when the diferric transferrin concentration was 5 microM.	Iron	135-139	transferrin	Rattus norvegicus	37-48
3415986-6	1988	At a low incubation concentration of transferrin (0.5 microM), the presence of both rat albumin and the antibody decreased the rate of iron uptake by the cells to about 15% of the value found in their absence, but to only 40% when the diferric transferrin concentration was 5 microM.	Iron	135-139	transferrin	Rattus norvegicus	244-255
3415986-7	1988	These results confirm that the uptake of transferrin-bound iron by both fetal and adult rat hepatocytes in culture occurs by a specific, receptor-mediated process and a low-affinity, non-saturable process.	Iron	59-63	transferrin	Rattus norvegicus	41-52
3408739-1	1988	The first spectroelectrochemical measurement of the formal reduction potential of iron transferrin has been carried out using methyl viologen to mediate electron transfer to the protein.	Iron	82-86	transferrin	Homo sapiens	87-98
2842153-3	1988	Porphyrin cytochrome c, the iron-free derivative of cytochrome c, has been used extensively as a fluorescent analog of cytochrome c.	Iron	28-32	cytochrome c, somatic	Homo sapiens	10-22
2842153-3	1988	Porphyrin cytochrome c, the iron-free derivative of cytochrome c, has been used extensively as a fluorescent analog of cytochrome c.	Iron	28-32	cytochrome c, somatic	Homo sapiens	52-64
2842153-3	1988	Porphyrin cytochrome c, the iron-free derivative of cytochrome c, has been used extensively as a fluorescent analog of cytochrome c.	Iron	28-32	cytochrome c, somatic	Homo sapiens	52-64
2842153-8	1988	The N-3 nitrogen of this residue forms one of the axial ligands to the iron in the intact cytochrome c but it is uncoordinated in the iron-free derivative.	Iron	71-75	cytochrome c, somatic	Homo sapiens	90-102
3407805-5	1988	Erythron iron uptake was increased in proportion to the increased receptor number in phenylhydrazine-treated animals but was reduced in iron deficiency because of the limited amount of iron-bearing transferrin.	Iron	9-13	transferrin	Rattus norvegicus	198-209
3183569-4	1988	It is concluded that germ cells normally located within the adluminal compartment of the seminiferous tubules may be capable of controlling their own supply of iron via their influence upon transferrin secretion by the Sertoli cells.	Iron	160-164	transferrin	Rattus norvegicus	190-201
3201894-0	1988	Differentiation of human erythroleukemia K562 cells without chemical inducer and the role of iron-saturated transferrin.	Iron	93-97	transferrin	Homo sapiens	108-119
3136803-0	1988	Iron environment in soybean lipoxygenase-1.	Iron	0-4	seed linoleate 13S-lipoxygenase-1	Glycine max	28-42
3219336-8	1988	It is proposed that the covalently labeled protein be used to test the hypothesis that iron removal from transferrin occurs by protonation and loss of the anion in low-pH lysosomal vesicles.	Iron	87-91	transferrin	Homo sapiens	105-116
3408739-4	1988	A high ionic strength was necessary to effect reduction, supporting the observation that ions play an important role in the reduction of iron in transferrin.	Iron	137-141	transferrin	Homo sapiens	145-156
2844718-3	1988	Compared with control animals, tibialis anterior skeletal muscles of iron-deficient animals exhibited reduced concentrations of cytochrome c (4.4 +/- 0.7 vs. 8.6 +/- 0.7 nmol/g tissue; P less than 0.01), and reduced activities of citrate synthase (83 +/- 10 vs. 133 +/- 13 mU/mg protein; P less than 0.01) and cytochrome-c oxidase (2.2 +/- 0.2 vs. 3.6 +/- 0.5 U/mg protein; P less than 0.05).	Iron	69-73	citrate synthase, mitochondrial	Oryctolagus cuniculus	230-246
2484545-7	1988	CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with ConA stimulation in presence of Zn or Fe.	Iron	115-117	CD4 molecule	Homo sapiens	0-3
2840023-4	1988	The electronic state of the Co(II) ion provides a useful probe to estimate how ligation to iron-containing subunits changes the structure of the cobalt-substituted heme vicinity as described previously (T. Inubushi and T. Yonetani (1983) Biochemistry 22, 1894-1900).	Iron	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
2844250-4	1988	When the oxidase in the aerobic steady state, with porphyrin cytochrome c (the iron-free derivative of cytochrome c) bound to it, is subjected to pressure, the porphyrin derivative is released.	Iron	79-83	cytochrome c, somatic	Homo sapiens	61-73
2844250-4	1988	When the oxidase in the aerobic steady state, with porphyrin cytochrome c (the iron-free derivative of cytochrome c) bound to it, is subjected to pressure, the porphyrin derivative is released.	Iron	79-83	cytochrome c, somatic	Homo sapiens	103-115
2839550-7	1988	Further experiments examining the effects of agents that affect iron metabolism show that the addition of transferrin-iron or hemin to the media is associated with a more rapid initial rate of proliferation and lower rates of transferrin synthesis than control cells.	Iron	64-68	transferrin	Homo sapiens	106-117
3291986-4	1988	When the same cells were grown in Fe-supplemented, protein-free medium (RPMI-Fe), insulin and IGF-I caused dose-dependent stimulation of HL60 cell growth with half-maximal stimulation at nanogram concentrations.	Iron	34-36	insulin	Homo sapiens	82-89
3291986-4	1988	When the same cells were grown in Fe-supplemented, protein-free medium (RPMI-Fe), insulin and IGF-I caused dose-dependent stimulation of HL60 cell growth with half-maximal stimulation at nanogram concentrations.	Iron	34-36	insulin like growth factor 1	Homo sapiens	94-99
3390939-0	1988	Effect of iron saturation on the TDx transferrin assay.	Iron	10-14	transferrin	Homo sapiens	37-48
2839550-7	1988	Further experiments examining the effects of agents that affect iron metabolism show that the addition of transferrin-iron or hemin to the media is associated with a more rapid initial rate of proliferation and lower rates of transferrin synthesis than control cells.	Iron	118-122	transferrin	Homo sapiens	106-117
2839550-7	1988	Further experiments examining the effects of agents that affect iron metabolism show that the addition of transferrin-iron or hemin to the media is associated with a more rapid initial rate of proliferation and lower rates of transferrin synthesis than control cells.	Iron	118-122	transferrin	Homo sapiens	226-237
2839550-10	1988	We conclude that transferrin synthesis by these malignant cells is ultimately related to an iron requirement for cellular proliferation.	Iron	92-96	transferrin	Homo sapiens	17-28
2845224-1	1988	The expression of human transferrin and lactoferrin binding activity in Haemophilus influenzae, detected by a binding assay using human transferrin or lactoferrin conjugated to peroxidase, was regulated by the level of available iron in the medium.	Iron	229-233	transferrin	Homo sapiens	24-35
3379048-0	1988	Uptake of iron from transferrin by isolated rat hepatocytes.	Iron	10-14	transferrin	Rattus norvegicus	20-31
3379048-2	1988	The uptake of iron from transferrin by isolated rat hepatocytes varies in parallel with plasma membrane NADH:ferricyanide oxidoreductase activity, is inhibited by ferricyanide, ferric, and ferrous iron chelators, divalent transition metal cations, and depends on calcium ions.	Iron	14-18	transferrin	Rattus norvegicus	24-35
3379048-2	1988	The uptake of iron from transferrin by isolated rat hepatocytes varies in parallel with plasma membrane NADH:ferricyanide oxidoreductase activity, is inhibited by ferricyanide, ferric, and ferrous iron chelators, divalent transition metal cations, and depends on calcium ions.	Iron	197-201	transferrin	Rattus norvegicus	24-35
3379048-4	1988	The results are compatible with a model in which iron, at transferrin concentrations above that needed to saturate the transferrin receptor, is taken up from transferrin predominantly by mechanisms located to or contiguous with the plasma membrane.	Iron	49-53	transferrin	Rattus norvegicus	58-69
3379048-4	1988	The results are compatible with a model in which iron, at transferrin concentrations above that needed to saturate the transferrin receptor, is taken up from transferrin predominantly by mechanisms located to or contiguous with the plasma membrane.	Iron	49-53	transferrin	Rattus norvegicus	119-130
3379048-5	1988	The process involves labilization and reduction of transferrin-bound iron by cooperative proton and electron fluxes.	Iron	69-73	transferrin	Rattus norvegicus	51-62
3377511-8	1988	The results are consistent with the hypothesis that gastrin and transferrin act synergistically in the uptake of dietary iron by the gastrointestinal tract.	Iron	121-125	transferrin	Homo sapiens	64-75
3292685-1	1988	Treatment of EMT-6 mammary adenocarcinoma cells with gamma interferon (rMuIFN gamma) plus tumor necrosis factor (rMuTNF alpha) and/or interleukin-1 (rHuIL-1 alpha) causes release of iron-55 label, inhibition of DNA replication, and inhibition of aconitase activity.	Iron	182-186	interferon gamma	Mus musculus	53-111
3294334-4	1988	Dietary iron depletion resulted in anemia (hematocrit 25 vs. 46%), microcytosis (MCV 54 vs. 60 fl), and reduced transferrin saturation (17 vs. 96%) without any effect on infection (peak parasitemia 30 vs. 36%).	Iron	8-12	transferrin	Rattus norvegicus	112-123
3134021-7	1988	Our results suggest that the antigrowth effect of IFN gamma is at least partly due to its inhibitory action on transferrin receptor expression leading to iron starvation.	Iron	154-158	interferon gamma	Homo sapiens	50-59
3134021-7	1988	Our results suggest that the antigrowth effect of IFN gamma is at least partly due to its inhibitory action on transferrin receptor expression leading to iron starvation.	Iron	154-158	transferrin	Homo sapiens	111-122
3259467-1	1988	Transferrin, the major iron-binding protein in the plasma of vertebrate species, is an essential growth factor for cells in serum free medium.	Iron	23-27	transferrin	Homo sapiens	0-11
3370673-0	1988	A stem-loop in the 3" untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm.	Iron	51-55	transferrin	Homo sapiens	80-91
3370673-1	1988	Expression of the human transferrin receptor (hTR) and its mRNA is strongly induced by iron deprivation.	Iron	87-91	telomerase RNA component	Homo sapiens	46-49
3370673-6	1988	The 3" untranslated region of hTR cDNA was sufficient to confer iron-dependent regulation on another gene.	Iron	64-68	telomerase RNA component	Homo sapiens	30-33
2845224-1	1988	The expression of human transferrin and lactoferrin binding activity in Haemophilus influenzae, detected by a binding assay using human transferrin or lactoferrin conjugated to peroxidase, was regulated by the level of available iron in the medium.	Iron	229-233	transferrin	Homo sapiens	136-147
2845224-5	1988	Competition binding assays also showed that iron-loaded transferrin was more effective at blocking the transferrin receptor than apotransferrin, but no differences in receptor blocking were observed between iron-loaded lactoferrin and apolactoferrin.	Iron	44-48	transferrin	Homo sapiens	56-67
2845224-5	1988	Competition binding assays also showed that iron-loaded transferrin was more effective at blocking the transferrin receptor than apotransferrin, but no differences in receptor blocking were observed between iron-loaded lactoferrin and apolactoferrin.	Iron	44-48	transferrin	Homo sapiens	103-114
3395656-8	1988	Energy transfer from tryptophan to a pyridoxamine derivatized side group in RNase increased 40% over 25 degrees C. Here we report further testing of this model in two additional protein systems: calmodulin, a calcium activated regulatory protein, and transferrin, a blood serum iron shuttle.	Iron	278-282	transferrin	Homo sapiens	251-262
3169034-0	1988	Transferrin iron interactions with cultured hepatocellular carcinoma cells (PLC/PRF/5).	Iron	12-16	transferrin	Homo sapiens	0-11
3408780-6	1988	Iron-saturated (holo-) transferrin was a more potent stimulator of rat placental cell DNA synthesis than was iron-free (apo-) transferrin.	Iron	0-4	transferrin	Rattus norvegicus	23-34
3169034-3	1988	Transferrin recycling was confirmed by the demonstration of a progressive increase in the cellular molar ratios of iron to transferrin and by chase experiments.	Iron	115-119	transferrin	Homo sapiens	0-11
3169034-10	1988	The endocytosed iron in hepatoma cells was found in association with ferritin (33%), transferrin (31%) and a low molecular weight fraction (21%).	Iron	16-20	transferrin	Homo sapiens	85-96
3401541-2	1988	Double-labeled [( 59Fe125I]) transferrin has been used to study the fate of transferrin and iron.	Iron	92-96	transferrin	Rattus norvegicus	29-40
2843167-3	1988	The hydroxyl-radical formation enhanced by SOD was inhibited by catalase and desferrioxamine, and stimulated by EDTA and diethylenetriaminepenta-acetic acid, suggesting that both hydrogen peroxide and iron ions participate in the reaction.	Iron	201-205	superoxide dismutase 1	Homo sapiens	43-46
3134296-0	1988	Mechanisms underlying T-lymphocyte activation: mitogen initiates and IL-2 amplifies the expression of transferrin receptors via intracellular iron level.	Iron	142-146	interleukin 2	Homo sapiens	69-73
3134296-0	1988	Mechanisms underlying T-lymphocyte activation: mitogen initiates and IL-2 amplifies the expression of transferrin receptors via intracellular iron level.	Iron	142-146	transferrin	Homo sapiens	102-113
3134296-4	1988	These observations suggest that mitogen triggers an IL-2-independent expression of TfRs, at least in part via a decrease of intracellular iron level.	Iron	138-142	interleukin 2	Homo sapiens	52-56
3401541-6	1988	Both rat and human transferrin transport iron into the cells and recycle back to the surface, and do so with identical kinetics.	Iron	41-45	transferrin	Homo sapiens	19-30
3372446-7	1988	H X H and H X M hybridomas respond similarly to three different iron chelates exhibiting 80 to 110% of the growth response to human transferrin.	Iron	64-68	transferrin	Homo sapiens	132-143
3383429-0	1988	Random distribution of iron among the two binding sites of transferrin in patients with various hematologic disorders.	Iron	23-27	transferrin	Homo sapiens	59-70
3383429-1	1988	The distribution of iron among the two binding sites of transferrin was studied by isoelectric focusing in 41 patients with a variety of disorders of iron metabolism and erythropoiesis.	Iron	20-24	transferrin	Homo sapiens	56-67
3383429-3	1988	It is concluded that iron distribution on transferrin is random or close to random within the experimental error in patients with a variety of clinical disorders.	Iron	21-25	transferrin	Homo sapiens	42-53
3371425-0	1988	Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis.	Iron	67-71	transferrin	Homo sapiens	14-25
3371425-2	1988	However, since the only clearly defined function of transferrin is iron transport, it may merely serve as an iron donor.	Iron	67-71	transferrin	Homo sapiens	52-63
3371425-2	1988	However, since the only clearly defined function of transferrin is iron transport, it may merely serve as an iron donor.	Iron	109-113	transferrin	Homo sapiens	52-63
3371425-3	1988	To further clarify this issue, we took advantage of an iron chelate, ferric salicylaldehyde isonicotinoyl hydrazone (Fe-SIH), which we developed and previously demonstrated to efficiently supply iron to cells without using physiological transferrin receptor pathway.	Iron	55-59	transferrin	Homo sapiens	237-248
3371425-3	1988	To further clarify this issue, we took advantage of an iron chelate, ferric salicylaldehyde isonicotinoyl hydrazone (Fe-SIH), which we developed and previously demonstrated to efficiently supply iron to cells without using physiological transferrin receptor pathway.	Iron	195-199	transferrin	Homo sapiens	237-248
3371425-5	1988	This inhibited cell growth was rescued upon the addition of Fe-SIH which was also shown to deliver iron to Raji cells in the presence of blocking anti-transferrin receptor antibodies.	Iron	99-103	transferrin	Homo sapiens	151-162
3371425-8	1988	Taken together, these results indicate that the only function of transferrin in supporting cell proliferation is to supply cells with iron.	Iron	134-138	transferrin	Homo sapiens	65-76
3047970-1	1988	Problems of ferrokinetics, participation of metalloproteins transferrin, ferritin and lactoferrin in metabolism of iron at the step of the metal absorption, transport of iron by means of transferrin, haptoglobin and hemopexin, interaction of transferrin with reticulocytes, deposition of iron in ferritin, mobilization of iron from ferritin via ceruloplasmin are considered.	Iron	115-119	transferrin	Homo sapiens	60-71
3047970-1	1988	Problems of ferrokinetics, participation of metalloproteins transferrin, ferritin and lactoferrin in metabolism of iron at the step of the metal absorption, transport of iron by means of transferrin, haptoglobin and hemopexin, interaction of transferrin with reticulocytes, deposition of iron in ferritin, mobilization of iron from ferritin via ceruloplasmin are considered.	Iron	115-119	transferrin	Homo sapiens	187-198
3047970-1	1988	Problems of ferrokinetics, participation of metalloproteins transferrin, ferritin and lactoferrin in metabolism of iron at the step of the metal absorption, transport of iron by means of transferrin, haptoglobin and hemopexin, interaction of transferrin with reticulocytes, deposition of iron in ferritin, mobilization of iron from ferritin via ceruloplasmin are considered.	Iron	115-119	haptoglobin	Homo sapiens	200-211
3047970-1	1988	Problems of ferrokinetics, participation of metalloproteins transferrin, ferritin and lactoferrin in metabolism of iron at the step of the metal absorption, transport of iron by means of transferrin, haptoglobin and hemopexin, interaction of transferrin with reticulocytes, deposition of iron in ferritin, mobilization of iron from ferritin via ceruloplasmin are considered.	Iron	115-119	transferrin	Homo sapiens	187-198
3355862-3	1988	HTF-14, a monoclonal antibody against human transferrin, reacts with rabbit transferrin and inhibits iron uptake and heme synthesis by rabbit reticulocytes.	Iron	101-105	transferrin	Homo sapiens	44-55
3377990-7	1988	These results indicate that a high affinity, carrier mediated iron transport system is present in the reticulocyte membrane, ensuring the efficient translocation of the metal through the membrane barrier between the site of its release from transferrin and the site of its utilization.	Iron	62-66	transferrin	Homo sapiens	241-252
3390148-1	1988	Haem controls the rate of haem synthesis in erythroid cells by inhibiting iron incorporation from transferrin.	Iron	74-78	transferrin	Homo sapiens	98-109
3390148-2	1988	The present results indicate that haem primarily inhibits the release of iron from transferrin subsequent to transferrin endocytosis and that the inhibition of transferrin endocytosis caused by relatively high concentrations of haem is a secondary effect.	Iron	73-77	transferrin	Homo sapiens	83-94
3390148-2	1988	The present results indicate that haem primarily inhibits the release of iron from transferrin subsequent to transferrin endocytosis and that the inhibition of transferrin endocytosis caused by relatively high concentrations of haem is a secondary effect.	Iron	73-77	transferrin	Homo sapiens	109-120
3390148-2	1988	The present results indicate that haem primarily inhibits the release of iron from transferrin subsequent to transferrin endocytosis and that the inhibition of transferrin endocytosis caused by relatively high concentrations of haem is a secondary effect.	Iron	73-77	transferrin	Homo sapiens	109-120
3355890-0	1988	Quantitation of ferritin iron in plasma, an explanation for non-transferrin iron.	Iron	25-29	transferrin	Homo sapiens	64-75
2964410-4	1988	Among nonheme sources of protein-bound iron, growth of H. influenzae was enhanced by partially saturated human transferrin but not by lactoferrin or ferritin.	Iron	39-43	transferrin	Homo sapiens	111-122
3355890-4	1988	Plasma transferrin was usually saturated with iron in patients with measurable ferritin iron, but exceptions occurred.	Iron	46-50	transferrin	Homo sapiens	7-18
3355890-4	1988	Plasma transferrin was usually saturated with iron in patients with measurable ferritin iron, but exceptions occurred.	Iron	88-92	transferrin	Homo sapiens	7-18
3355890-5	1988	In studies using electrophoretic separation, it was shown that some ferritin iron moved to transferrin during in vitro incubation, whereas exchange in the opposite direction was extremely limited.	Iron	77-81	transferrin	Homo sapiens	91-102
3163302-6	1988	The altered transferrin receptor cycle led to a diminished iron uptake per surface transferrin receptor (approximately 30% of that in healthy subjects), and the incorporation of iron into heme was greatly reduced.	Iron	59-63	transferrin	Homo sapiens	12-23
3163302-6	1988	The altered transferrin receptor cycle led to a diminished iron uptake per surface transferrin receptor (approximately 30% of that in healthy subjects), and the incorporation of iron into heme was greatly reduced.	Iron	178-182	transferrin	Homo sapiens	12-23
3126143-1	1988	The major iron (Fe) sources available to Neisseria gonorrhoeae in the human host are probably transferrin (TF) and lactoferrin (LF).	Iron	10-14	transferrin	Homo sapiens	94-105
3126143-1	1988	The major iron (Fe) sources available to Neisseria gonorrhoeae in the human host are probably transferrin (TF) and lactoferrin (LF).	Iron	10-14	transferrin	Homo sapiens	107-109
3126143-1	1988	The major iron (Fe) sources available to Neisseria gonorrhoeae in the human host are probably transferrin (TF) and lactoferrin (LF).	Iron	16-18	transferrin	Homo sapiens	94-105
3126143-1	1988	The major iron (Fe) sources available to Neisseria gonorrhoeae in the human host are probably transferrin (TF) and lactoferrin (LF).	Iron	16-18	transferrin	Homo sapiens	107-109
2833250-0	1988	Susceptibilities of lactoferrin and transferrin to myeloperoxidase-dependent loss of iron-binding capacity.	Iron	85-89	transferrin	Homo sapiens	36-47
3344685-9	1988	This study demonstrates that diminished iron stores in cyanotic congenital heart disease are associated with a more right-shifted oxyhemoglobin dissociation curve (increased P50).	Iron	40-44	nuclear factor kappa B subunit 1	Homo sapiens	174-177
3162685-1	1988	Cellular iron uptake is mediated by binding of transferrin with specific surface receptors and internalization of the Fe-transferrin-receptor complex.	Iron	9-13	transferrin	Homo sapiens	47-58
2833250-0	1988	Susceptibilities of lactoferrin and transferrin to myeloperoxidase-dependent loss of iron-binding capacity.	Iron	85-89	myeloperoxidase	Homo sapiens	51-66
3162685-1	1988	Cellular iron uptake is mediated by binding of transferrin with specific surface receptors and internalization of the Fe-transferrin-receptor complex.	Iron	9-13	transferrin	Homo sapiens	121-132
2833250-1	1988	Apolactoferrin and apotransferrin lost their ability to subsequently bind iron when exposed to an excess of either HOCl or myeloperoxidase plus H2O2 and Cl-.	Iron	74-78	myeloperoxidase	Homo sapiens	123-138
3355798-6	1988	The molecular weight of these complexes is similar to that of the non-transferrin plasma iron found in the serum of patients with iron overload.	Iron	89-93	transferrin	Homo sapiens	70-81
2833250-3	1988	By oxidizing a mixture of the two proteins, then separating them by immunoprecipitation, the difference in susceptibility was shown to be due to the greater reactivity of transferrin iron-binding groups, rather than protective groups on the lactoferrin molecule.	Iron	183-187	transferrin	Homo sapiens	171-182
3355798-6	1988	The molecular weight of these complexes is similar to that of the non-transferrin plasma iron found in the serum of patients with iron overload.	Iron	130-134	transferrin	Homo sapiens	70-81
3355798-7	1988	The toxic effects of small polynuclear non-transferrin plasma Fe(III) complexes on PMN function may contribute to the development of infections in patients with iron overload.	Iron	161-165	transferrin	Homo sapiens	43-54
3350861-6	1988	The results suggest that nicotine acts by blocking uptake, probably by acting as a weak base inhibiting iron release from transferrin, and inhibiting exocytosis with a resultant block of endocytosis.	Iron	104-108	transferrin	Rattus norvegicus	122-133
3338996-0	1988	Non-transferrin-bound iron uptake by rat liver.	Iron	22-26	transferrin	Rattus norvegicus	4-15
3041406-1	1988	Receptor-mediated endocytosis is generally assumed to be the process by which the haemochorial placenta takes up iron from transferrin.	Iron	113-117	transferrin	Homo sapiens	123-134
3341769-0	1988	The role of iron chelates on the selectivity of Fenton reagent in hydroxylation, N-demethylation, and sulfoxidation of cimetidine: a novel biomimetic model for the regioselectivity of cytochrome P-450.	Iron	12-16	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	184-200
3132585-1	1988	Expression of the meningococcal transferrin receptor, detected by assay with human transferrin conjugated to peroxidase, was regulated by the level of iron in the medium.	Iron	151-155	transferrin	Homo sapiens	32-43
3132585-1	1988	Expression of the meningococcal transferrin receptor, detected by assay with human transferrin conjugated to peroxidase, was regulated by the level of iron in the medium.	Iron	151-155	transferrin	Homo sapiens	83-94
3132585-2	1988	The transferrin receptor was identified by SDS-PAGE and Western blot analysis, as a 71,000 molecular weight iron-regulated outer membrane protein in Neisseria meningitidis B16B6.	Iron	108-112	transferrin	Homo sapiens	4-15
3132585-3	1988	Growth studies with iron-deficient cells and competition binding experiments demonstrated that the meningococcal receptor was species-specific for human transferrin.	Iron	20-24	transferrin	Homo sapiens	153-164
3162307-1	1988	Iron regulation of the human transferrin receptor gene was examined in murine cells transformed with chimeric constructs containing the human transferrin receptor gene"s promoter and either the structural gene for bacterial chloramphenicol acetyltransferase or the human transferrin receptor cDNA.	Iron	0-4	transferrin	Homo sapiens	29-40
3162307-2	1988	The activity of the transferrin receptor gene"s promoter with the heterologous indicator gene was found to be approximately equal to 3-fold higher in cells treated with the iron chelator desferrioxamine than in cells treated with the iron source, hemin.	Iron	173-177	transferrin	Homo sapiens	20-31
3162307-2	1988	The activity of the transferrin receptor gene"s promoter with the heterologous indicator gene was found to be approximately equal to 3-fold higher in cells treated with the iron chelator desferrioxamine than in cells treated with the iron source, hemin.	Iron	234-238	transferrin	Homo sapiens	20-31
3162307-3	1988	A higher degree of iron regulation was seen in the expression of the human transferrin receptor cDNA driven by its own promoter.	Iron	19-23	transferrin	Homo sapiens	75-86
3162307-7	1988	We conclude that at least two genetic elements exist for the regulation of the transferrin receptor gene by iron.	Iron	108-112	transferrin	Homo sapiens	79-90
3338996-2	1988	Non-transferrin-bound iron is efficiently cleared from serum by the liver and may be primarily responsible for the hepatic damage seen in iron-overload states.	Iron	22-26	transferrin	Rattus norvegicus	4-15
3338996-2	1988	Non-transferrin-bound iron is efficiently cleared from serum by the liver and may be primarily responsible for the hepatic damage seen in iron-overload states.	Iron	138-142	transferrin	Rattus norvegicus	4-15
3338996-12	1988	These findings are consistent with an electrogenic transport mechanism for uptake of non-transferrin-bound iron that is driven by the transmembrane potential difference.	Iron	107-111	transferrin	Rattus norvegicus	89-100
3396268-2	1988	Caeruloplasmin and transferrin act as antioxidants in serum by oxidizing and chelating ferrous iron which could otherwise act as a catalyst in free radical reactions.	Iron	95-99	transferrin	Homo sapiens	19-30
3128034-4	1988	Allowance for the amount of each has made possible the calculation of iron-bearing transferrin uptake, which is independent of plasma iron concentration as long as receptors are saturated.	Iron	70-74	transferrin	Homo sapiens	83-94
3337844-6	1988	(3) In the presence of apotransferrin in the culture medium, part of the iron was found as transferrin iron.	Iron	73-77	transferrin	Rattus norvegicus	26-37
3337844-6	1988	(3) In the presence of apotransferrin in the culture medium, part of the iron was found as transferrin iron.	Iron	103-107	transferrin	Rattus norvegicus	26-37
3346338-9	1988	In a comparison of human and chick transferrin mediated iron uptake, chick transferrin was 50% more effective than human transferrin in transporting iron.	Iron	56-60	transferrin	Homo sapiens	35-46
3346338-9	1988	In a comparison of human and chick transferrin mediated iron uptake, chick transferrin was 50% more effective than human transferrin in transporting iron.	Iron	56-60	transferrin	Homo sapiens	75-86
3346338-9	1988	In a comparison of human and chick transferrin mediated iron uptake, chick transferrin was 50% more effective than human transferrin in transporting iron.	Iron	56-60	transferrin	Homo sapiens	75-86
3346338-9	1988	In a comparison of human and chick transferrin mediated iron uptake, chick transferrin was 50% more effective than human transferrin in transporting iron.	Iron	149-153	transferrin	Homo sapiens	75-86
3346338-9	1988	In a comparison of human and chick transferrin mediated iron uptake, chick transferrin was 50% more effective than human transferrin in transporting iron.	Iron	149-153	transferrin	Homo sapiens	75-86
3291683-6	1988	The pathogenetic factors in the development of diabetes mellitus in patients with idiopathic hemochromatosis include impaired insulin secretion caused by the selective deposition of iron in B-cells of the pancreas and insulin resistance due to iron accumulation in the liver.	Iron	182-186	insulin	Homo sapiens	126-133
3218790-0	1988	[The coefficient of saturation of iron in transferrin].	Iron	34-38	transferrin	Homo sapiens	42-53
3218790-1	1988	Theoretical iron fixation capacity of transferrin (FCT) can be calculated on its immunochemical titration: (FCT (mumol/l = transferrin (g/l) x 25).	Iron	12-16	transferrin	Homo sapiens	38-49
3218790-1	1988	Theoretical iron fixation capacity of transferrin (FCT) can be calculated on its immunochemical titration: (FCT (mumol/l = transferrin (g/l) x 25).	Iron	12-16	transferrin	Homo sapiens	123-134
3276135-1	1988	The laboratory measurement of serum transferrin is a valuable adjunct in the assessment of both iron and protein nutritional status.	Iron	96-100	transferrin	Homo sapiens	36-47
3291683-7	1988	In particular, the insulin resistance is markedly improved after depletion of body iron stores by phlebotomy treatment, resulting in lower insulin requirements in patients with insulin-dependent diabetes as well as improvement of carbohydrate metabolisms in about half of the patients with non-insulin-dependent diabetes.	Iron	83-87	insulin	Homo sapiens	19-26
3291683-7	1988	In particular, the insulin resistance is markedly improved after depletion of body iron stores by phlebotomy treatment, resulting in lower insulin requirements in patients with insulin-dependent diabetes as well as improvement of carbohydrate metabolisms in about half of the patients with non-insulin-dependent diabetes.	Iron	83-87	insulin	Homo sapiens	139-146
3291685-2	1988	Iron and the iron-binding proteins can act as regulators of immune function, and not only as a result of a nutritional dependence of lymphoid cells on transferrin and transferrin-iron.	Iron	0-4	transferrin	Rattus norvegicus	151-162
3291685-2	1988	Iron and the iron-binding proteins can act as regulators of immune function, and not only as a result of a nutritional dependence of lymphoid cells on transferrin and transferrin-iron.	Iron	0-4	transferrin	Rattus norvegicus	167-178
3291685-2	1988	Iron and the iron-binding proteins can act as regulators of immune function, and not only as a result of a nutritional dependence of lymphoid cells on transferrin and transferrin-iron.	Iron	13-17	transferrin	Rattus norvegicus	151-162
3291685-2	1988	Iron and the iron-binding proteins can act as regulators of immune function, and not only as a result of a nutritional dependence of lymphoid cells on transferrin and transferrin-iron.	Iron	13-17	transferrin	Rattus norvegicus	167-178
3291685-2	1988	Iron and the iron-binding proteins can act as regulators of immune function, and not only as a result of a nutritional dependence of lymphoid cells on transferrin and transferrin-iron.	Iron	179-183	transferrin	Rattus norvegicus	167-178
3291685-15	1988	Transient increases in serum iron concentration above the full saturation of transferrin, reproducing the clinical situation frequently seen in hereditary hemochromatosis, are followed by a series of cellular changes in the synovium that can be correlated to changes in the course of an experimental model of arthritis in the rat.	Iron	29-33	transferrin	Rattus norvegicus	77-88
3291688-0	1988	The role of liver endothelium in the transfer of iron from transferrin to the hepatocyte.	Iron	49-53	transferrin	Homo sapiens	59-70
3390570-0	1988	Characteristics of iron exchange between transferrin and hepatocytes in culture.	Iron	19-23	transferrin	Homo sapiens	41-52
3152869-4	1988	The weak-field spectra of the [N-57Fe]transferrin are slightly broader than those of the [C-57Fe]transferrin, indicating that the N-terminal iron site may be more heterogeneous.	Iron	141-145	transferrin	Homo sapiens	38-49
3152869-4	1988	The weak-field spectra of the [N-57Fe]transferrin are slightly broader than those of the [C-57Fe]transferrin, indicating that the N-terminal iron site may be more heterogeneous.	Iron	141-145	transferrin	Homo sapiens	97-108
3180141-4	1988	Malignant cells requiring more iron modulate a transferrin receptor and the iron transporting protein transferrin delivers iron to the cell.	Iron	31-35	transferrin	Rattus norvegicus	47-58
3180141-4	1988	Malignant cells requiring more iron modulate a transferrin receptor and the iron transporting protein transferrin delivers iron to the cell.	Iron	31-35	transferrin	Homo sapiens	102-113
3180141-4	1988	Malignant cells requiring more iron modulate a transferrin receptor and the iron transporting protein transferrin delivers iron to the cell.	Iron	76-80	transferrin	Homo sapiens	102-113
3338792-6	1988	The serum iron concentrations in Africans were decreased; the free iron-binding capacity of TF was, thus, increased.	Iron	67-71	transferrin	Homo sapiens	92-94
3391030-0	1988	Effect of erythropoietin on iron kinetics in patients with end-stage renal disease.	Iron	28-32	erythropoietin	Homo sapiens	10-24
2853113-0	1988	Iron release from metmyoglobin, methaemoglobin and cytochrome c by a system generating hydrogen peroxide.	Iron	0-4	cytochrome c, somatic	Homo sapiens	51-63
2853113-4	1988	Cytochrome-c, methaemoglobin and metmyoglobin during interaction with H2O2 at a concentration of 200 microM release 40%, 20% and 3%, respectively, of molecular iron after 10 min.	Iron	160-164	cytochrome c, somatic	Homo sapiens	0-12
3171105-4	1988	However DFO was not found to inhibit iron uptake directly, and relatively low concentrations of iron as iron-transferrin totally reversed the inhibitory action of DFO on thymidine uptake.	Iron	96-100	transferrin	Homo sapiens	109-120
3210997-5	1988	Non-linear relationships existed between both iron and transferrin uptake and the degree of activation.	Iron	46-50	transferrin	Homo sapiens	55-66
3169362-6	1988	However, adriamycin, at low concentration, is able to take up some iron from a 20% iron-saturated transferrin solution; a reaction which may take place in vivo.	Iron	67-71	transferrin	Homo sapiens	98-109
3169362-6	1988	However, adriamycin, at low concentration, is able to take up some iron from a 20% iron-saturated transferrin solution; a reaction which may take place in vivo.	Iron	83-87	transferrin	Homo sapiens	98-109
2891784-0	1988	Tyrosine hydroxylase activity in caudate nucleus from Parkinson"s disease: effects of iron and phosphorylating agents.	Iron	86-90	tyrosine hydroxylase	Homo sapiens	0-20
3121514-0	1988	Impact of proteases on iron uptake of Pseudomonas aeruginosa pyoverdin from transferrin and lactoferrin.	Iron	23-27	transferrin	Homo sapiens	76-87
3121514-2	1988	However, in the presence of P. aeruginosa elastase, rapid iron release and pyoverdin iron uptake from transferrin but not from lactoferrin were detected.	Iron	85-89	transferrin	Homo sapiens	102-113
3053498-8	1988	The Sertoli cells have developed a system to move serum-derived iron through their own cytoplasm and to secrete it bound to newly synthesized testicular transferrin molecules which can deliver it to specific receptors on the germinal cell surface (Huggenvik et al., 1984).	Iron	64-68	transferrin	Rattus norvegicus	153-164
3422446-2	1988	Plasma transferrin receptors were measured by ELISA in rats of different age and sex, of different iron status, with different degrees of erythropoiesis, and with inflammation.	Iron	99-103	transferrin	Rattus norvegicus	7-18
3072501-9	1988	The Sertoli cell-mediated iron transport to germ cells via transferrin is the clearest demonstration of this interaction.	Iron	26-30	transferrin	Homo sapiens	59-70
2840655-5	1988	The residues at 416 in myeloperoxidase and 407 in thyroid peroxidase were estimated as possible candidates for the proximal histidine residues that link to the iron centers of the enzymes.	Iron	160-164	myeloperoxidase	Homo sapiens	23-38
3133754-2	1988	Incubation of iron-loaded transferrin with iron-free pyoverdin for 10 h at 40 degrees C in the presence of Ela yielded pyoverdin-iron(III) complex, in contrast to incubations of transferrin with pyoverdin alone, AP, or PMN Ela.	Iron	14-18	transferrin	Homo sapiens	26-37
3133754-2	1988	Incubation of iron-loaded transferrin with iron-free pyoverdin for 10 h at 40 degrees C in the presence of Ela yielded pyoverdin-iron(III) complex, in contrast to incubations of transferrin with pyoverdin alone, AP, or PMN Ela.	Iron	43-47	transferrin	Homo sapiens	26-37
3429053-0	1987	Transport of transferrin-bound iron into rat Sertoli cells and spermatids.	Iron	31-35	transferrin	Rattus norvegicus	13-24
3222734-2	1988	The most informative laboratory indices of iron metabolism were defined (transferrin saturation with iron and the level of ferritin in the serum and erythrocytes).	Iron	43-47	transferrin	Homo sapiens	73-84
3222734-2	1988	The most informative laboratory indices of iron metabolism were defined (transferrin saturation with iron and the level of ferritin in the serum and erythrocytes).	Iron	101-105	transferrin	Homo sapiens	73-84
2445597-4	1987	The results obtained suggest (1) that the human leukemic K562 cells treated with monoclonal antibodies to human transferrin receptor might retain molecular properties similar to those found in erythroid cells from subjects affected by alterations of iron metabolism, and (2) that hemin might allow hemoglobin synthesis in erythroid cells whose iron uptake is inhibited by monoclonal antibodies to human transferrin receptors.	Iron	250-254	transferrin	Homo sapiens	112-123
2445597-4	1987	The results obtained suggest (1) that the human leukemic K562 cells treated with monoclonal antibodies to human transferrin receptor might retain molecular properties similar to those found in erythroid cells from subjects affected by alterations of iron metabolism, and (2) that hemin might allow hemoglobin synthesis in erythroid cells whose iron uptake is inhibited by monoclonal antibodies to human transferrin receptors.	Iron	344-348	transferrin	Homo sapiens	112-123
3452592-0	1987	Mobilization of iron from serum transferrin following lead acetate administration in rats.	Iron	16-20	transferrin	Rattus norvegicus	32-43
3122747-5	1987	By contrast, catalase, but not superoxide dismutase, prevents the cell killing dependent upon addition of ferrous iron.	Iron	106-118	catalase	Homo sapiens	13-21
3676519-4	1987	After iron supplementation in iron deficiency anemia, the serum transferrin receptor values increased twofold over those of pretreatment values.	Iron	6-10	transferrin	Homo sapiens	64-75
3691443-3	1987	Iron status was defined by percentage transferrin saturation (PTS).	Iron	0-4	transferrin	Homo sapiens	38-49
3429053-1	1987	Transferrin (Tf), a major secretory protein of Sertoli cells, may transport iron to spermatogenic cells.	Iron	76-80	transferrin	Rattus norvegicus	0-11
3429053-1	1987	Transferrin (Tf), a major secretory protein of Sertoli cells, may transport iron to spermatogenic cells.	Iron	76-80	transferrin	Rattus norvegicus	13-15
3429053-2	1987	This was assessed by measuring the uptake of Fe from 59Fe-125I-labelled rat Tf by Sertoli cells and round spermatids in vitro.	Iron	45-47	transferrin	Rattus norvegicus	76-78
3429053-3	1987	Uptake of Fe from labelled Tf by Sertoli cells after a 72-h pre-incubation period was linear for 20 h (approximately 18 pmol/10(6) cells/20 h), whereas the uptake of Fe from labelled Tf by round spermatids after a 16-h pre-incubation period reached a plateau by 2 h (approximately 5 pmol/10(6) cells/2 h).	Iron	10-12	transferrin	Rattus norvegicus	27-29
3429053-3	1987	Uptake of Fe from labelled Tf by Sertoli cells after a 72-h pre-incubation period was linear for 20 h (approximately 18 pmol/10(6) cells/20 h), whereas the uptake of Fe from labelled Tf by round spermatids after a 16-h pre-incubation period reached a plateau by 2 h (approximately 5 pmol/10(6) cells/2 h).	Iron	166-168	transferrin	Rattus norvegicus	183-185
3429053-8	1987	It is concluded that iron from exogenous Tf is transported into Sertoli cells and round spermatids in vitro, and is complexed to intracellular ferritin.	Iron	21-25	transferrin	Rattus norvegicus	41-43
3433005-7	1987	The results are consistent with receptor-mediated endocytosis as one mechanism for hepatocyte uptake of iron from transferrin but also suggest an alternative route by which transferrin can donate its iron to the cells and rapidly be released to the extracellular environment without undergoing a complete transferrin cycle.	Iron	104-108	transferrin	Rattus norvegicus	114-125
3681115-3	1987	There was a highly significant (P less than 0.001) decrease in receptor preference for diferric transferrin in subjects with iron deficiency, indicating an insufficient amount of iron-bearing transferrin to saturate tissue receptors.	Iron	125-129	transferrin	Homo sapiens	96-107
3681115-4	1987	The adequacy of the plasma iron supply was also examined by determining the number of iron-bearing transferrin molecules with receptors at normal and elevated plasma iron concentrations.	Iron	86-90	transferrin	Homo sapiens	99-110
3681115-4	1987	The adequacy of the plasma iron supply was also examined by determining the number of iron-bearing transferrin molecules with receptors at normal and elevated plasma iron concentrations.	Iron	86-90	transferrin	Homo sapiens	99-110
2849026-1	1987	We tested the in vitro binding of human iron-sequestering lactoferrin and transferrin by the mucosal-surface pathogens, Mycoplasma pneumoniae and Mycoplasma genitalium.	Iron	40-44	transferrin	Homo sapiens	74-85
3433005-0	1987	Uptake of iron from transferrin by isolated hepatocytes.	Iron	10-14	transferrin	Rattus norvegicus	20-31
3433005-2	1987	The subcellular distribution of iron and transferrin has been studied in isolated rat hepatocytes during uptake of transferrin iron.	Iron	32-36	transferrin	Rattus norvegicus	115-126
3441921-2	1987	Iron-loaded transferrin (FeTF) but not apotransferrin (apoTF) significantly enhanced the mitogenic response of MNL in serum-free culture.	Iron	0-4	transferrin	Homo sapiens	12-23
3433005-7	1987	The results are consistent with receptor-mediated endocytosis as one mechanism for hepatocyte uptake of iron from transferrin but also suggest an alternative route by which transferrin can donate its iron to the cells and rapidly be released to the extracellular environment without undergoing a complete transferrin cycle.	Iron	200-204	transferrin	Rattus norvegicus	173-184
3433005-2	1987	The subcellular distribution of iron and transferrin has been studied in isolated rat hepatocytes during uptake of transferrin iron.	Iron	127-131	transferrin	Rattus norvegicus	115-126
3433005-3	1987	Iron and transferrin are both rapidly transferred from an extracellular to an intracellular compartment in a process which is slowed down when the cells are deprived of ATP and completely blocked when the cells are incubated at 4 degrees C. The transfer of iron occurs at a higher rate than transferrin.	Iron	0-4	transferrin	Rattus norvegicus	291-302
3433005-7	1987	The results are consistent with receptor-mediated endocytosis as one mechanism for hepatocyte uptake of iron from transferrin but also suggest an alternative route by which transferrin can donate its iron to the cells and rapidly be released to the extracellular environment without undergoing a complete transferrin cycle.	Iron	200-204	transferrin	Rattus norvegicus	173-184
3433005-3	1987	Iron and transferrin are both rapidly transferred from an extracellular to an intracellular compartment in a process which is slowed down when the cells are deprived of ATP and completely blocked when the cells are incubated at 4 degrees C. The transfer of iron occurs at a higher rate than transferrin.	Iron	257-261	transferrin	Rattus norvegicus	9-20
3433005-3	1987	Iron and transferrin are both rapidly transferred from an extracellular to an intracellular compartment in a process which is slowed down when the cells are deprived of ATP and completely blocked when the cells are incubated at 4 degrees C. The transfer of iron occurs at a higher rate than transferrin.	Iron	257-261	transferrin	Rattus norvegicus	291-302
3680232-11	1987	Because the transmembrane electron transport has been shown to stimulate cell growth, the reduction of diferric transferrin at the cell surface may be an important function for diferric transferrin in stimulation of cell growth, in addition to its role in iron transport.	Iron	256-260	transferrin	Rattus norvegicus	112-123
3427061-0	1987	Electron transfer from cytochrome b5 to iron and copper complexes.	Iron	40-44	cytochrome b5 type A	Bos taurus	23-36
2827739-1	1987	Electron paramagnetic resonance (EPR) studies of the nitrosyl adduct of ferrous lactoperoxidase (LPO) confirm that the fifth axial ligand in LPO is bound to the iron via a nitrogen atom.	Iron	161-165	lactoperoxidase	Homo sapiens	80-95
2827739-1	1987	Electron paramagnetic resonance (EPR) studies of the nitrosyl adduct of ferrous lactoperoxidase (LPO) confirm that the fifth axial ligand in LPO is bound to the iron via a nitrogen atom.	Iron	161-165	lactoperoxidase	Homo sapiens	97-100
2827739-1	1987	Electron paramagnetic resonance (EPR) studies of the nitrosyl adduct of ferrous lactoperoxidase (LPO) confirm that the fifth axial ligand in LPO is bound to the iron via a nitrogen atom.	Iron	161-165	lactoperoxidase	Homo sapiens	141-144
2825600-5	1987	Addition of high concentrations of catalase, but not superoxide dismutase, to the incubations provided some protection against the toxic effect of diquat, but much better protection was observed when catalase was added in combination with the iron chelator desferrioxamine.	Iron	243-247	catalase	Homo sapiens	35-43
3673932-5	1987	This screening test almost completely differentiated between 40 normal individuals and 40 patients with iron overload (as defined by a transferrin saturation greater than 55%).	Iron	104-108	transferrin	Homo sapiens	135-146
3689862-9	1987	Thus, our results demonstrated a unidirectional system of iron transport from the basal compartment of the seminiferous epithelium to the germ cells in the adluminal compartment involving two distinct transferrins, i.e., a serum transferrin and a testicular transferrin synthesized by the seminiferous epithelium.	Iron	58-62	transferrin	Rattus norvegicus	201-212
2823714-15	1987	and H2O, or the prosthetic group to give rise to oxidative cleavage of the porphyrin ring structure of the heme moiety of LPO and thus to the liberation of iron.	Iron	156-160	lactoperoxidase	Homo sapiens	122-125
2823718-0	1987	Chemiluminescence studies on the generation of oxygen radicals from the interaction of NADPH-cytochrome P-450 reductase with iron.	Iron	125-129	cytochrome p450 oxidoreductase	Homo sapiens	87-119
2823718-1	1987	The ability of NADPH-cytochrome P-450 reductase to interact with iron and generate oxygen radicals was evaluated by assaying for low level chemiluminescence.	Iron	65-69	cytochrome p450 oxidoreductase	Homo sapiens	15-47
3689862-9	1987	Thus, our results demonstrated a unidirectional system of iron transport from the basal compartment of the seminiferous epithelium to the germ cells in the adluminal compartment involving two distinct transferrins, i.e., a serum transferrin and a testicular transferrin synthesized by the seminiferous epithelium.	Iron	58-62	transferrin	Rattus norvegicus	229-240
3125486-4	1987	Iron absorption from 59Fe-labelled transferrin was inhibited by the addition of rat plasma.	Iron	0-4	transferrin	Rattus norvegicus	35-46
3312497-1	1987	Transferrin (Tf), the iron mobilization protein, is synthesized mainly in the liver.	Iron	22-26	transferrin	Rattus norvegicus	0-11
3312497-1	1987	Transferrin (Tf), the iron mobilization protein, is synthesized mainly in the liver.	Iron	22-26	transferrin	Rattus norvegicus	13-15
3312497-7	1987	Regional variation in the amount of Tf was in general agreement with published reports on the variation of iron and Tf receptor levels in the CNS.	Iron	107-111	transferrin	Rattus norvegicus	36-38
3679087-3	1987	We now report effects of iron-loading on three enzymes of heme synthesis: 5-aminolevulinate synthase; the first and rate-controlling enzyme of the pathway, 5-aminolevulinate dehydrase (or porphobilinogen synthase), and uroporphyrinogen decarboxylase, the activity of which is decreased in porphyria cutanea tarda, a liver disease in which iron is known to play an important but still poorly understood role.	Iron	25-29	aminolevulinate dehydratase	Rattus norvegicus	188-212
3143887-0	1987	Isolation by streptonigrin enrichment and characterization of a transferrin-specific iron uptake mutant of Neisseria meningitidis.	Iron	85-89	transferrin	Homo sapiens	64-75
3143887-3	1987	One such mutant, FAM29, was impaired in its use of transferrin-bound iron; transferrin is the principal iron-binding protein in human plasma.	Iron	69-73	transferrin	Homo sapiens	51-62
3143887-3	1987	One such mutant, FAM29, was impaired in its use of transferrin-bound iron; transferrin is the principal iron-binding protein in human plasma.	Iron	69-73	transferrin	Homo sapiens	75-86
3143887-3	1987	One such mutant, FAM29, was impaired in its use of transferrin-bound iron; transferrin is the principal iron-binding protein in human plasma.	Iron	104-108	transferrin	Homo sapiens	75-86
2961489-6	1987	The data provide further evidence that low concentrations of non-transferrin-bound Fe3+, of the same order as those reported to be present in the serum of patients with iron-overload, have significant immunoregulatory properties.	Iron	169-173	transferrin	Homo sapiens	65-76
3314661-4	1987	This method has already made it possible to explain several mechanisms involving the control of proteins in iron metabolism such as transferrin and ferritin.	Iron	108-112	transferrin	Homo sapiens	132-143
3681344-0	1987	Recombinant human tumor necrosis factor depresses serum iron in mice.	Iron	56-60	tumor necrosis factor	Homo sapiens	18-39
3691756-0	1987	Variation in iron accumulation, transferrin membrane binding and DNA synthesis in the K-562 and U-937 cell lines induced by chelators and their iron complexes.	Iron	144-148	transferrin	Homo sapiens	32-43
3691756-2	1987	The lipophilic chelators suppressed the accumulation of Tf-supplied iron in the K-562 cells and less so in the U-937 cells, whereas the effects of the other chelators were closer to control range.	Iron	68-72	transferrin	Homo sapiens	56-58
3693344-0	1987	Involvement of transferrin in the reduction of iron by the transplasma membrane electron transport system.	Iron	47-51	transferrin	Homo sapiens	15-26
3693344-4	1987	Ferric ammonium citrate can also be used as an electron acceptor and the presence of low concentrations of diferric transferrin greatly stimulates the reduction of trivalent iron under these conditions.	Iron	174-178	transferrin	Homo sapiens	116-127
3681344-2	1987	In the present study, the effect of rHu-TNF on serum iron in C3H/HeN and C57BL/6 mice was determined.	Iron	53-57	tumor necrosis factor	Mus musculus	40-43
3681344-4	1987	Results from five experiments showed that the serum iron was depressed between 1/3 to 1/5 of that of untreated mice 4 to 24 h after injection of 5 or 10 micrograms of rHu-TNF.	Iron	52-56	tumor necrosis factor	Mus musculus	171-174
3681344-7	1987	We believe that this is the first report of depression of serum iron in mice by intravenous injection of rHu-TNF.	Iron	64-68	tumor necrosis factor	Mus musculus	109-112
3681344-8	1987	The physiological role of repressed serum iron in the in vivo response to TNF remains to be established.	Iron	42-46	tumor necrosis factor	Mus musculus	74-77
3127578-16	1987	injection of a large dose of IFN-gamma (6 x 10(6) units/kg) induced an acute phase response, which included a reduction in plasma concentration of iron and zinc.	Iron	147-151	interferon gamma	Oryctolagus cuniculus	29-38
3478338-0	1987	Iron uptake from transferrin and transferrin endocytic cycle in Friend erythroleukemia cells.	Iron	0-4	transferrin	Homo sapiens	17-28
3478338-2	1987	The maximal rate of iron uptake from 59Fe-labeled transferrin, 1.5 X 10(6) atoms of Fe/cell per 30 min in uninduced cells, increased to 3 X 10(6) atoms/cell after 5 days of induction.	Iron	20-24	transferrin	Homo sapiens	50-61
3478338-7	1987	On the basis of these results, different efficiency of iron release from internalized transferrin, accompanied by changes in cellular transferrin kinetics, is proposed as one of the factors determining the rate of iron uptake by developing erythroid cells.	Iron	55-59	transferrin	Homo sapiens	86-97
3478338-7	1987	On the basis of these results, different efficiency of iron release from internalized transferrin, accompanied by changes in cellular transferrin kinetics, is proposed as one of the factors determining the rate of iron uptake by developing erythroid cells.	Iron	55-59	transferrin	Homo sapiens	134-145
3478338-7	1987	On the basis of these results, different efficiency of iron release from internalized transferrin, accompanied by changes in cellular transferrin kinetics, is proposed as one of the factors determining the rate of iron uptake by developing erythroid cells.	Iron	214-218	transferrin	Homo sapiens	86-97
3478338-7	1987	On the basis of these results, different efficiency of iron release from internalized transferrin, accompanied by changes in cellular transferrin kinetics, is proposed as one of the factors determining the rate of iron uptake by developing erythroid cells.	Iron	214-218	transferrin	Homo sapiens	134-145
3498714-11	1987	These data demonstrate that the accumulation of iron by cultured cells is a complex function of the rate of cycling of the transferrin receptor and that this process is under acute regulation by growth factors.	Iron	48-52	transferrin	Homo sapiens	123-134
2821542-7	1987	The conformational rearrangement induced in cytochrome c by cytochrome c oxidase consists of a structural rearrangement of the heme environment and possibly a change of the geometry of the heme iron-methionine-80 sulfur axial bond.	Iron	135-139	cytochrome c, somatic	Homo sapiens	44-56
2821542-7	1987	The conformational rearrangement induced in cytochrome c by cytochrome c oxidase consists of a structural rearrangement of the heme environment and possibly a change of the geometry of the heme iron-methionine-80 sulfur axial bond.	Iron	135-139	cytochrome c, somatic	Homo sapiens	60-72
3651826-2	1987	When transferrin is added, the toxic effect of iron is increased.	Iron	47-51	transferrin	Homo sapiens	5-16
3476165-1	1987	Surface transferrin (Tf) receptors are displayed by cultured human hematopoietic cells and provide Fe required for cell growth.	Iron	99-101	transferrin	Homo sapiens	8-19
3476165-1	1987	Surface transferrin (Tf) receptors are displayed by cultured human hematopoietic cells and provide Fe required for cell growth.	Iron	99-101	transferrin	Homo sapiens	21-23
3476165-2	1987	Cell cycle status, cell density in culture, exposure to Fe, and differentiation alter Tf receptor display by myeloid leukemia cells.	Iron	56-58	transferrin	Homo sapiens	86-88
3476165-5	1987	Cells grown with soluble Fe instead of Tf showed reduced Tf binding sites, rates of receptor synthesis, and Tf receptor mRNA.	Iron	25-27	transferrin	Homo sapiens	57-59
3476165-5	1987	Cells grown with soluble Fe instead of Tf showed reduced Tf binding sites, rates of receptor synthesis, and Tf receptor mRNA.	Iron	25-27	transferrin	Homo sapiens	57-59
3476165-13	1987	Nuclear transcription studies showed reduced rates of Tf receptor transcription after culture with Fe or exposure to DMSO.	Iron	99-101	transferrin	Homo sapiens	54-56
3308665-1	1987	The major part of hepatocellular iron is derived from uptake of transferrin-bound iron by means of nonspecific fluid-phase endocytosis and specific, saturable binding on high-affinity transferrin receptors.	Iron	33-37	transferrin	Homo sapiens	64-75
3114372-12	1987	However, prior treatment of MPM with transferrin enabled the cells to display a greater parasite killing capacity after ApoLF treatment, suggesting a role for iron in this activity.	Iron	159-163	transferrin	Homo sapiens	37-48
3306281-6	1987	In conclusion, these studies characterize the human BBB transferrin receptor and support the hypothesis that this receptor acts as a transport system which mediates the transcytosis of transferrin-bound iron through the brain capillary endothelial cell in man.	Iron	203-207	transferrin	Homo sapiens	56-67
3306281-6	1987	In conclusion, these studies characterize the human BBB transferrin receptor and support the hypothesis that this receptor acts as a transport system which mediates the transcytosis of transferrin-bound iron through the brain capillary endothelial cell in man.	Iron	203-207	transferrin	Homo sapiens	185-196
3308665-1	1987	The major part of hepatocellular iron is derived from uptake of transferrin-bound iron by means of nonspecific fluid-phase endocytosis and specific, saturable binding on high-affinity transferrin receptors.	Iron	33-37	transferrin	Homo sapiens	184-195
3308665-1	1987	The major part of hepatocellular iron is derived from uptake of transferrin-bound iron by means of nonspecific fluid-phase endocytosis and specific, saturable binding on high-affinity transferrin receptors.	Iron	82-86	transferrin	Homo sapiens	64-75
3308665-1	1987	The major part of hepatocellular iron is derived from uptake of transferrin-bound iron by means of nonspecific fluid-phase endocytosis and specific, saturable binding on high-affinity transferrin receptors.	Iron	82-86	transferrin	Homo sapiens	184-195
3308665-10	1987	This finding is in keeping with the inverse relation between transferrin receptor expression and exogenous iron supply in various cell cultures.	Iron	107-111	transferrin	Homo sapiens	61-72
3308665-11	1987	These results indicate that in hemochromatosis,apparently as a result of progressive iron overload,transferrin receptor expression on hepatocytes disappears.	Iron	85-89	transferrin	Homo sapiens	99-110
3626617-2	1987	This method allowed better resolution of the overlapping bands of cytochrome P-450 and other iron proteins, as well as a reduction of the effects of turbidity and non-specific components.	Iron	93-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
3497931-0	1987	Iron-transferrin-induced increase in protein kinase C activity in CCRF-CEM cells.	Iron	0-4	transferrin	Homo sapiens	5-16
3497931-1	1987	Iron transferrin has been found to induce a mean 10-fold increase in the activity of protein kinase C in CCRF-CEM cells.	Iron	0-4	transferrin	Homo sapiens	5-16
3497931-2	1987	This increase was not detectable up to 45 min after treatment of cells with iron transferrin, although after 60 min, a maximal increase in enzyme activity was observed.	Iron	76-80	transferrin	Homo sapiens	81-92
3497931-3	1987	Similarly, iron transferrin at concentrations of 0.1-0.5 microgram/ml did not alter protein kinase C activity, while concentrations of iron transferrin of 1-100 micrograms/ml induced a maximal increase in enzyme activity.	Iron	11-15	transferrin	Homo sapiens	16-27
3497931-3	1987	Similarly, iron transferrin at concentrations of 0.1-0.5 microgram/ml did not alter protein kinase C activity, while concentrations of iron transferrin of 1-100 micrograms/ml induced a maximal increase in enzyme activity.	Iron	135-139	transferrin	Homo sapiens	140-151
3497931-5	1987	Additionally, CCRF-CEM cells pretreated with either actinomycin D or cycloheximide and then incubated with iron transferrin did not exhibit increased enzyme activity.	Iron	107-111	transferrin	Homo sapiens	112-123
3497931-6	1987	Treatment with iron transferrin was found to have no effect on protein kinase C activity in normal human peripheral blood lymphocytes and in HL60, Daudi, and U937 cells.	Iron	15-19	transferrin	Homo sapiens	20-31
3497931-8	1987	These results indicate a specific effect of iron transferrin on protein kinase C activity in CCRF-CEM cells and in mitogen-stimulated human lymphocytes that may occur through increased synthesis of the enzyme.	Iron	44-48	transferrin	Homo sapiens	49-60
3663138-11	1987	Recent reports confirm that the two iron-binding domains of both OTf and human lactotransferrin associate non-covalently in solution.	Iron	36-40	lactotransferrin	Homo sapiens	79-95
3297421-4	1987	Results by an immunoprecipitation procedure, which measures only transferrin-bound iron, correlated well with those obtained coulometrically but were slightly higher than the latter.	Iron	83-87	transferrin	Homo sapiens	65-76
3595766-7	1987	These findings suggest that hbd/hbd reticulocytes have a defect in iron acquisition that is distal to the binding of transferrin to the cell membrane receptor.	Iron	67-71	exocyst complex component 6	Mus musculus	28-31
3595766-7	1987	These findings suggest that hbd/hbd reticulocytes have a defect in iron acquisition that is distal to the binding of transferrin to the cell membrane receptor.	Iron	67-71	exocyst complex component 6	Mus musculus	32-35
3611549-4	1987	The iron content of milk was generally low, but several samples had high levels.	Iron	4-8	Weaning weight-maternal milk	Bos taurus	20-24
2444216-0	1987	Bleomycin-detectable iron in knee-joint synovial fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin.	Iron	21-25	transferrin	Homo sapiens	163-174
2444216-3	1987	Patients whose fluids release iron have lower contents of transferrin, lactoferrin and caeruloplasmin than do patients whose fluids do not release iron to bleomycin.	Iron	30-34	transferrin	Homo sapiens	58-69
3593971-1	1987	The mechanisms underlying the impaired utilization of transferrin-bound iron by erythroid cells in the anemia of the Belgrade laboratory rat were investigated using reticulocytes from homozygous anemic animals and transferrin labeled with 59Fe and 125I.	Iron	72-76	transferrin	Rattus norvegicus	54-65
3305046-5	1987	A lipophilic iron chelator, ferric pyridoxal isonicotinoyl hydrazone (FePIH), can fully mimic the effect of transferrin on the proliferation of WB-F344 cells, but the molar concentration of transferrin.	Iron	13-17	transferrin	Rattus norvegicus	108-119
3305046-5	1987	A lipophilic iron chelator, ferric pyridoxal isonicotinoyl hydrazone (FePIH), can fully mimic the effect of transferrin on the proliferation of WB-F344 cells, but the molar concentration of transferrin.	Iron	13-17	transferrin	Rattus norvegicus	190-201
3305046-6	1987	These results suggest that the critical function of transferrin in the proliferation of WB-F344 cells may be in the delivery of iron to the cells.	Iron	128-132	transferrin	Rattus norvegicus	52-63
3597399-1	1987	Transferrin-mediated uptake and release of iron.	Iron	43-47	transferrin	Homo sapiens	0-11
3597399-4	1987	During iron uptake the transferrin and its receptor recycle at least each 19 min.	Iron	7-11	transferrin	Homo sapiens	23-34
3605065-1	1987	To clarify the role of transferrin receptors in cases of altered iron metabolism in clinical pathological conditions, we studied: number of binding sites; affinity; and recycling kinetics of transferrin receptors on human erythroblasts.	Iron	65-69	transferrin	Homo sapiens	23-34
2888478-2	1987	TH contains one ferrous iron per subunit and catalyzes the conversion of its tetrahydropterin cofactor to a 4a-carbinolamine concomitant with substrate hydroxylation.	Iron	24-28	tyrosine hydroxylase	Homo sapiens	0-2
3605065-8	1987	These data suggest that iron uptake is regulated by modulation of the number of surface transferrin receptors, thereby reflecting the iron demand of the erythroblast.	Iron	24-28	transferrin	Homo sapiens	88-99
3605065-8	1987	These data suggest that iron uptake is regulated by modulation of the number of surface transferrin receptors, thereby reflecting the iron demand of the erythroblast.	Iron	134-138	transferrin	Homo sapiens	88-99
3619079-3	1987	The presence of large amounts of ferritin in the cytoplasm of these cells suggests that they receive iron, presumably from circulating transferrin.	Iron	101-105	transferrin	Rattus norvegicus	135-146
3619079-8	1987	It is postulated that the iron responsible for enamel pigmentation is transported by transferrin to maturation ameloblasts and is bound to specific transferrin receptors found mostly on RAs and that the modulation of these cells into SAs results in a loss of most of these receptors.	Iron	26-30	transferrin	Rattus norvegicus	85-96
3606953-0	1987	Non-transferrin plasma iron.	Iron	23-27	transferrin	Homo sapiens	4-15
3619079-8	1987	It is postulated that the iron responsible for enamel pigmentation is transported by transferrin to maturation ameloblasts and is bound to specific transferrin receptors found mostly on RAs and that the modulation of these cells into SAs results in a loss of most of these receptors.	Iron	26-30	transferrin	Rattus norvegicus	148-159
3622525-0	1987	Transferrin receptors and transferrin iron uptake by cultured human blood monocytes.	Iron	38-42	transferrin	Homo sapiens	26-37
3622525-1	1987	Transferrin receptors have been previously found on human macrophages and it has also been shown that transferrin iron is taken up by these cells.	Iron	114-118	transferrin	Homo sapiens	0-11
3622525-1	1987	Transferrin receptors have been previously found on human macrophages and it has also been shown that transferrin iron is taken up by these cells.	Iron	114-118	transferrin	Homo sapiens	102-113
3622525-7	1987	Inhibitors of endocytic vesicle acidification (ammonium chloride and 2,4-dinitrophenol) inhibited iron unloading from endocytosed diferric transferrin, while microtubular inhibitors (colchicine and vindesine) and a microfilament inhibitor (cytochalasin B) reduced diferric transferrin uptake but had little effect on the iron unloading pathway.	Iron	98-102	transferrin	Homo sapiens	139-150
3112484-6	1987	Unlike the photoreaction, X/XO/iron-dependent peroxidation and lysis was inhibited by catalase, superoxide dismutase and phenolic antioxidants, indicating O2-/H2O2 intermediacy and a free radical mechanism.	Iron	31-35	catalase	Homo sapiens	86-94
3568132-1	1987	The transferrin receptor (TR) mediates cellular iron uptake by bringing about the endocytosis of transferrin.	Iron	48-52	transferrin	Homo sapiens	4-15
3578091-4	1987	A greater reduction in iron absorption occurred in iron-deficient rats when transferrin iron was injected into gut loops.	Iron	23-27	transferrin	Rattus norvegicus	76-87
3569539-0	1987	Iron transfer from ferritin to transferrin.	Iron	0-4	transferrin	Homo sapiens	31-42
3578091-4	1987	A greater reduction in iron absorption occurred in iron-deficient rats when transferrin iron was injected into gut loops.	Iron	51-55	transferrin	Rattus norvegicus	76-87
3578091-4	1987	A greater reduction in iron absorption occurred in iron-deficient rats when transferrin iron was injected into gut loops.	Iron	51-55	transferrin	Rattus norvegicus	76-87
3578500-7	1987	The mechanism involved was further investigated by studying the effect of the chelators on uptake of transferrin-bound iron by placental cells in culture.	Iron	119-123	transferrin	Rattus norvegicus	101-112
3578500-10	1987	The results can be explained if the iron is released from the transferrin in intracellular vesicles in the ferrous form, where it may be chelated by bipyridine and prevented from passing to the fetus or converted to the ferric form once it is inside the cell matrix.	Iron	36-40	transferrin	Rattus norvegicus	62-73
3578091-5	1987	Mucosal radioiron content in animals given cadmium with either iron salts or transferrin iron was increased.	Iron	13-17	transferrin	Rattus norvegicus	77-88
3578091-6	1987	The primary effect of cadmium was on intracellular processing of iron salts and transferrin iron.	Iron	92-96	transferrin	Rattus norvegicus	80-91
2444207-5	1987	In all three cell types iron delivery occurs, as concluded from the increase in cellular 59Fe/125I ratio at prolonged circulation times of transferrin.	Iron	24-28	transferrin	Rattus norvegicus	139-150
2436948-2	1987	This iron contamination can be removed from buffers and reagents using a dialysis sac containing a high-affinity iron-binding protein like conalbumin or transferrin without altering the pH value of the fluid.	Iron	5-9	transferrin	Homo sapiens	153-164
3579983-10	1987	Since the fast phase of enzymatic lipid peroxidation occurred during the fast phase of destruction of cytochrome P-450, it is postulated that iron made available from cytochrome P-450 is sufficient to promote optimal lipid peroxidation.	Iron	142-146	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	102-118
3579983-10	1987	Since the fast phase of enzymatic lipid peroxidation occurred during the fast phase of destruction of cytochrome P-450, it is postulated that iron made available from cytochrome P-450 is sufficient to promote optimal lipid peroxidation.	Iron	142-146	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	167-183
3593649-5	1987	A comparison of the lactoferrin- and the transferrin-mediated iron processing by monocytes is finally presented.	Iron	62-66	transferrin	Homo sapiens	41-52
3608980-0	1987	Noncoding 3" sequences of the transferrin receptor gene are required for mRNA regulation by iron.	Iron	92-96	transferrin	Homo sapiens	30-41
3608980-1	1987	The cell-surface receptor for transferrin mediates cellular uptake of iron from serum.	Iron	70-74	transferrin	Homo sapiens	30-41
3608980-3	1987	Here we report that expression of human transferrin receptor cDNA constructions in stably transfected mouse fibroblasts is regulated both by the iron chelator, desferrioxamine, and by hemin.	Iron	145-149	transferrin	Homo sapiens	40-51
2436948-2	1987	This iron contamination can be removed from buffers and reagents using a dialysis sac containing a high-affinity iron-binding protein like conalbumin or transferrin without altering the pH value of the fluid.	Iron	113-117	transferrin	Homo sapiens	153-164
3629151-12	1987	In the elderly subjects in Romania the circadian rhythm in serum iron concentration was in phase with the circadian rhythms in total serum bilirubin and alkaline phosphatase but showed significant phase differences from the circadian rhythms in serum albumin, urea nitrogen (BUN), gammaglutamyl transferase (Gamma-GT), serum globulins, glucose, insulin and total serum proteins.	Iron	65-69	insulin	Homo sapiens	345-352
3031028-7	1987	When myeloperoxidase was isolated from the cells incubated with [59Fe]heme-hemopexin complex by immunoprecipitation with anti-myeloperoxidase antibody, radiolabeled iron associated with myeloperoxidase increased with time, and more than 30% of the radioactivity in the cells was present in the myeloperoxidase.	Iron	165-169	myeloperoxidase	Homo sapiens	5-20
3031028-7	1987	When myeloperoxidase was isolated from the cells incubated with [59Fe]heme-hemopexin complex by immunoprecipitation with anti-myeloperoxidase antibody, radiolabeled iron associated with myeloperoxidase increased with time, and more than 30% of the radioactivity in the cells was present in the myeloperoxidase.	Iron	165-169	myeloperoxidase	Homo sapiens	126-141
3031028-7	1987	When myeloperoxidase was isolated from the cells incubated with [59Fe]heme-hemopexin complex by immunoprecipitation with anti-myeloperoxidase antibody, radiolabeled iron associated with myeloperoxidase increased with time, and more than 30% of the radioactivity in the cells was present in the myeloperoxidase.	Iron	165-169	myeloperoxidase	Homo sapiens	126-141
3031028-7	1987	When myeloperoxidase was isolated from the cells incubated with [59Fe]heme-hemopexin complex by immunoprecipitation with anti-myeloperoxidase antibody, radiolabeled iron associated with myeloperoxidase increased with time, and more than 30% of the radioactivity in the cells was present in the myeloperoxidase.	Iron	165-169	myeloperoxidase	Homo sapiens	126-141
3606854-17	1987	HTr preparations, the rate measured over a 2-h period amounted to approximately 12,700 and 16,100 Fe atoms/(cell .	Iron	98-100	telomerase RNA component	Homo sapiens	0-3
3606854-27	1987	HTr may bind Fe in different ways depending on the method of Fe presentation and that the Fe .	Iron	13-15	telomerase RNA component	Homo sapiens	0-3
3606854-27	1987	HTr may bind Fe in different ways depending on the method of Fe presentation and that the Fe .	Iron	61-63	telomerase RNA component	Homo sapiens	0-3
3606854-27	1987	HTr may bind Fe in different ways depending on the method of Fe presentation and that the Fe .	Iron	61-63	telomerase RNA component	Homo sapiens	0-3
3606854-28	1987	HTr product can donate Fe to K-562 cells at a rate which may reflect the method used for Fe-complex formation.	Iron	23-25	telomerase RNA component	Homo sapiens	0-3
3606854-28	1987	HTr product can donate Fe to K-562 cells at a rate which may reflect the method used for Fe-complex formation.	Iron	89-91	telomerase RNA component	Homo sapiens	0-3
3565925-0	1987	Antioxidant activity of serum ceruloplasmin and transferrin available iron-binding capacity in smokers and nonsmokers.	Iron	70-74	transferrin	Homo sapiens	48-59
3817292-0	1987	Iron supports myogenic cell differentiation to the same degree as does iron-bound transferrin.	Iron	71-75	transferrin	Homo sapiens	82-93
2440461-0	1987	Biological effect of transferrin on mast cell mediator release during the passive cutaneous anaphylaxis reaction: a possible inhibition mechanism involving iron.	Iron	156-160	transferrin	Rattus norvegicus	21-32
2440461-6	1987	Iron and iron-saturated transferrin could play a role in the mechanism of desensitization by modulating the responsiveness of mast cells.	Iron	9-13	transferrin	Rattus norvegicus	24-35
3815806-2	1987	Quantitative studies demonstrate that the protein transferrin (iron-free) is the strongest Al3+ binder in blood plasma.	Iron	63-67	transferrin	Homo sapiens	50-61
3600812-5	1987	The distribution of iron in the body to the tissues and organs is handled by transferrin, a protein that binds iron so tightly that scarcely any free, i.e., ionized and hence toxic iron can exist.	Iron	20-24	transferrin	Homo sapiens	77-88
3600812-5	1987	The distribution of iron in the body to the tissues and organs is handled by transferrin, a protein that binds iron so tightly that scarcely any free, i.e., ionized and hence toxic iron can exist.	Iron	111-115	transferrin	Homo sapiens	77-88
3600812-5	1987	The distribution of iron in the body to the tissues and organs is handled by transferrin, a protein that binds iron so tightly that scarcely any free, i.e., ionized and hence toxic iron can exist.	Iron	111-115	transferrin	Homo sapiens	77-88
3592625-1	1987	Transferrin is an iron-carrying compound that stimulates cell growth and division by binding to specific receptors (TR) which are preferentially expressed by actively growing cells or by the malignant counterpart of normal cells.	Iron	18-22	transferrin	Homo sapiens	0-11
3552028-3	1987	Fe-deficiency was defined as a low serum ferritin concentration (12 micrograms/l or less), combined with a low transferrin saturation (less than 16%) or a high erythrocyte protoporphyrin level (more than 3 micrograms/g Hb), or both.	Iron	0-2	transferrin	Homo sapiens	111-122
3817292-3	1987	B 57, 206-210) have shown that Fe ion can promote myogenic cell growth as Fe-bound transferrin.	Iron	31-33	transferrin	Homo sapiens	83-94
3817292-3	1987	B 57, 206-210) have shown that Fe ion can promote myogenic cell growth as Fe-bound transferrin.	Iron	74-76	transferrin	Homo sapiens	83-94
3817292-6	1987	The degree of differentiation of myotubes cultured in the presence of Fe ion was almost the same as that of myotubes cultured in the presence of Fe-bound transferrin.	Iron	145-147	transferrin	Homo sapiens	154-165
3470297-9	1987	However, when the cells were induced by 56Fe-hemin in the presence of 57Fe-transferrin, 57Fe was incorporated only into ferritin, but not into Hb, which contained 56Fe iron.	Iron	168-172	transferrin	Homo sapiens	75-86
3028962-6	1987	Only the wild-type, aerobactin-producing strain could remove iron from transferrin or lactoferrin.	Iron	61-65	transferrin	Homo sapiens	71-82
3556310-0	1987	[Transferrin: its role in iron metabolism and various clinical aspects].	Iron	26-30	transferrin	Homo sapiens	1-12
3542299-0	1987	Plasma iron and transferrin iron-binding capacity evaluated by colorimetric and immunoprecipitation methods.	Iron	28-32	transferrin	Homo sapiens	16-27
3616117-3	1987	The dependence of the rate with respect to iron, apoferritin and ceruloplasmin concentrations was in general linear in the studied range.	Iron	43-47	ceruloplasmin	Gallus gallus	65-78
2437773-0	1987	Inhibition of histamine release in vitro by a blocking factor from human serum: comparison with the iron binding proteins transferrin and lactoferrin.	Iron	100-104	transferrin	Rattus norvegicus	122-133
2437773-5	1987	BF (DEAE-peak 1) and the iron binding proteins transferrin and lactoferrin (LF) are shown to inhibit the histamine release in vitro.	Iron	25-29	transferrin	Rattus norvegicus	47-58
3551609-0	1987	Transferrin-mediated cellular iron uptake.	Iron	30-34	transferrin	Homo sapiens	0-11
3551609-1	1987	The basic model for cellular uptake of iron relies on the iron-chelating protein transferrin (Tf), which is capable of binding iron under one set of conditions and releasing it under another set of conditions.	Iron	39-43	transferrin	Homo sapiens	81-92
3551609-1	1987	The basic model for cellular uptake of iron relies on the iron-chelating protein transferrin (Tf), which is capable of binding iron under one set of conditions and releasing it under another set of conditions.	Iron	39-43	transferrin	Homo sapiens	94-96
3551609-1	1987	The basic model for cellular uptake of iron relies on the iron-chelating protein transferrin (Tf), which is capable of binding iron under one set of conditions and releasing it under another set of conditions.	Iron	58-62	transferrin	Homo sapiens	81-92
3551609-1	1987	The basic model for cellular uptake of iron relies on the iron-chelating protein transferrin (Tf), which is capable of binding iron under one set of conditions and releasing it under another set of conditions.	Iron	58-62	transferrin	Homo sapiens	94-96
3551609-1	1987	The basic model for cellular uptake of iron relies on the iron-chelating protein transferrin (Tf), which is capable of binding iron under one set of conditions and releasing it under another set of conditions.	Iron	58-62	transferrin	Homo sapiens	81-92
3551609-1	1987	The basic model for cellular uptake of iron relies on the iron-chelating protein transferrin (Tf), which is capable of binding iron under one set of conditions and releasing it under another set of conditions.	Iron	58-62	transferrin	Homo sapiens	94-96
3551609-2	1987	Tf has specific membrane receptors on the surface of the cells that require iron.	Iron	76-80	transferrin	Homo sapiens	0-2
3551609-6	1987	Other models for cellular uptake of iron include extraction of iron from Tf on the cell surface without internalization, uptake by adsorptive mechanism, and fluid-phase endocytosis.	Iron	36-40	transferrin	Homo sapiens	73-75
3551609-6	1987	Other models for cellular uptake of iron include extraction of iron from Tf on the cell surface without internalization, uptake by adsorptive mechanism, and fluid-phase endocytosis.	Iron	63-67	transferrin	Homo sapiens	73-75
3025217-2	1987	The effect of the purple acid phosphatases with binuclear iron centers (uteroferrin and bovine spleen phosphatase) on hydroxyl radical formation by iron-catalyzed Haber-Weiss-Fenton chemistry has been compared to that of lactoferrin and transferrin.	Iron	148-152	serotransferrin	Bos taurus	237-248
3616117-0	1987	The incorporation of iron into chicken apoferritin in the presence of ceruloplasmin.	Iron	21-25	ceruloplasmin	Gallus gallus	70-83
3616117-1	1987	After assaying the appropriate conditions for the experiments, the oxidation of iron with incorporation into chicken apoferritin was studied in the presence of ceruloplasmin, analysing the roles of iron, apoferritin and ceruloplasmin.	Iron	80-84	ceruloplasmin	Gallus gallus	160-173
3616117-1	1987	After assaying the appropriate conditions for the experiments, the oxidation of iron with incorporation into chicken apoferritin was studied in the presence of ceruloplasmin, analysing the roles of iron, apoferritin and ceruloplasmin.	Iron	80-84	ceruloplasmin	Gallus gallus	220-233
3548194-3	1987	When iron levels in serum were assayed colorimetrically, there appeared to be a progressive rise in the mean concentration during the course of the insulin infusion.	Iron	5-9	insulin	Homo sapiens	148-155
3028266-0	1987	Ferredoxin-thioredoxin reductase, an iron-sulfur enzyme linking light to enzyme regulation in oxygenic photosynthesis: purification and properties of the enzyme from C3, C4, and cyanobacterial species.	Iron	37-41	ferredoxin-thioredoxin reductase catalytic chain, chloroplastic	Zea mays	0-32
3828319-0	1987	Iron(III) clusters bound to horse spleen apoferritin: an X-ray absorption and Mossbauer spectroscopy study that shows that iron nuclei can form on the protein.	Iron	0-4	ferritin heavy chain	Equus caballus	41-52
3828319-0	1987	Iron(III) clusters bound to horse spleen apoferritin: an X-ray absorption and Mossbauer spectroscopy study that shows that iron nuclei can form on the protein.	Iron	123-127	ferritin heavy chain	Equus caballus	41-52
3828319-4	1987	Preliminary extended X-ray absorbance fine structure (EXAFS) analysis of the same Fe(III)-apoferritin complex showed an environment distinct from ferritin cores, but the data did not allow a test of the Fe cluster hypothesis.	Iron	82-84	ferritin heavy chain	Equus caballus	90-101
3537801-9	1987	These results demonstrate that recombinant human erythropoietin is effective, can eliminate the need for transfusions with their risks of immunologic sensitization, infection, and iron overload, and can restore the hematocrit to normal in many patients with the anemia of end-stage renal disease.	Iron	180-184	erythropoietin	Homo sapiens	49-63
3542299-6	1987	Iron-deficient sera gave higher values for transferrin when measured by immunoelectrophoresis.	Iron	0-4	transferrin	Homo sapiens	43-54
3120472-6	1987	Transferrin iron saturation correlated less clearly with transfusion history than serum ferritin (r = 0.62).	Iron	12-16	transferrin	Homo sapiens	0-11
3542299-8	1987	Perhaps some exchange of iron occurred between added iron and transferrin iron in the isotope-dilution method.	Iron	25-29	transferrin	Homo sapiens	62-73
3542299-10	1987	However, the greater specificity of a polyclonal immunoprecipitation method of measuring PI and TIBC makes it particularly useful in differentiating transferrin-bound iron from nontransferrin iron.	Iron	167-171	transferrin	Homo sapiens	149-160
3813540-4	1987	Ferric cytochrome P-450 catalyzed the formation of these products as shown by the inability of boiled microsomes to support the reaction, the inhibition of epoxyhydroxy and trihydroxy fatty acid formation by imidazole derivatives which bind tightly to the ferric heme iron of cytochrome P-450, and the inability of carbon monoxide (which binds to ferrous P-450) and free iron chelators (EDTA and diethylenetriaminepentaacetic acid) to inhibit product formation.	Iron	268-272	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	7-23
3028261-1	1987	The interaction of various anions with human serum transferrin was investigated due to the concomitant binding of iron and a synergistic anion to form the transferrin-anion-iron complex.	Iron	114-118	transferrin	Homo sapiens	51-62
3028261-1	1987	The interaction of various anions with human serum transferrin was investigated due to the concomitant binding of iron and a synergistic anion to form the transferrin-anion-iron complex.	Iron	173-177	transferrin	Homo sapiens	51-62
3028261-1	1987	The interaction of various anions with human serum transferrin was investigated due to the concomitant binding of iron and a synergistic anion to form the transferrin-anion-iron complex.	Iron	173-177	transferrin	Homo sapiens	155-166
3028261-4	1987	Transferrin treated with a 3:1 molar ratio of periodate or permanganate to active sites lost 74 or 67% of its iron-binding capacity, respectively.	Iron	110-114	transferrin	Homo sapiens	0-11
3484368-1	1987	The present investigation was motivated from the consideration that a host environment rich in iron, represented by high serum transferrin saturation (TS) and high serum iron and serum ferritin levels might offer favorable growth conditions for leukemic cells in addition to infection, thus affecting survival.	Iron	78-82	transferrin	Homo sapiens	127-138
3484368-1	1987	The present investigation was motivated from the consideration that a host environment rich in iron, represented by high serum transferrin saturation (TS) and high serum iron and serum ferritin levels might offer favorable growth conditions for leukemic cells in addition to infection, thus affecting survival.	Iron	95-99	transferrin	Homo sapiens	127-138
3028261-7	1987	The interaction of phosphate ions with the iron-transferrin complex was also examined due to the increased susceptibility to periodate inactivation of iron-saturated transferrin in phosphate buffer (M. H. Penner, R. B. Yamasaki, D. T. Osuga, D. R. Babin, C. F. Meares, and R. E. Feeney (1983) Arch.	Iron	43-47	transferrin	Homo sapiens	48-59
3028261-11	1987	The apparent destabilization of the iron-transferrin complex in phosphate buffer was found to be due to the competitive removal of iron by phosphate from the iron-protein complex.	Iron	36-40	transferrin	Homo sapiens	41-52
3028261-11	1987	The apparent destabilization of the iron-transferrin complex in phosphate buffer was found to be due to the competitive removal of iron by phosphate from the iron-protein complex.	Iron	131-135	transferrin	Homo sapiens	41-52
3028261-12	1987	We found that phenylglyoxal-modified Fe-transferrin, with no loss of bound iron, was much more resistant to iron removal by phosphate and other competitive chelators.	Iron	108-112	transferrin	Homo sapiens	40-51
3813540-4	1987	Ferric cytochrome P-450 catalyzed the formation of these products as shown by the inability of boiled microsomes to support the reaction, the inhibition of epoxyhydroxy and trihydroxy fatty acid formation by imidazole derivatives which bind tightly to the ferric heme iron of cytochrome P-450, and the inability of carbon monoxide (which binds to ferrous P-450) and free iron chelators (EDTA and diethylenetriaminepentaacetic acid) to inhibit product formation.	Iron	371-375	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	7-23
3566771-1	1987	Diferric transferrin which is often necessary for growth of cells is reduced by the transplasma membrane electron transport system of HeLa cells with release of ferrous iron outside the cell.	Iron	161-173	transferrin	Homo sapiens	9-20
2833323-7	1987	These data suggest that catalase, hydroxyl radical scavengers, and iron chelators protect chemotactically stimulated neutrophils from autotoxicity caused by neutrophil-derived hydrogen peroxide and its iron-catalyzed conversion product, hydroxyl radical.	Iron	202-206	catalase	Rattus norvegicus	24-32
3032157-2	1987	Apo-lactoferrin and apo-transferrin protect against iron-ion-dependent hydroxyl-radical (.OH) generation from H2O2 in the presence of superoxide radicals or ascorbic acid at pH 7.4, whether the necessary iron is added as ionic iron or as ferritin.	Iron	52-56	transferrin	Homo sapiens	24-35
3026504-4	1987	In both PAH and transferrin, at least one of the iron sites is characterized by the ratio of zero-field splitting parameters, E/D, near 1/3 and a broad, asymmetric lineshape.	Iron	49-53	transferrin	Homo sapiens	16-27
3032157-2	1987	Apo-lactoferrin and apo-transferrin protect against iron-ion-dependent hydroxyl-radical (.OH) generation from H2O2 in the presence of superoxide radicals or ascorbic acid at pH 7.4, whether the necessary iron is added as ionic iron or as ferritin.	Iron	204-208	transferrin	Homo sapiens	24-35
3032157-2	1987	Apo-lactoferrin and apo-transferrin protect against iron-ion-dependent hydroxyl-radical (.OH) generation from H2O2 in the presence of superoxide radicals or ascorbic acid at pH 7.4, whether the necessary iron is added as ionic iron or as ferritin.	Iron	204-208	transferrin	Homo sapiens	24-35
3032157-3	1987	Iron-loaded transferrin and lactoferrin [2 mol of Fe(III)/mol] show no protective ability, but do not themselves accelerate .OH production unless chelating agents are present in the reaction mixture, especially if the proteins are incorrectly loaded with iron.	Iron	0-4	transferrin	Homo sapiens	12-23
3473987-6	1987	Hemin inhibits Tf-bound iron uptake by DMSO induced cells but not by the uninduced cells.	Iron	24-28	transferrin	Homo sapiens	15-17
3435503-6	1987	Highly purified sarcolemmal membranes, exhibiting an NaF-stimulated activity of 3.46 +/- 0.65 nmol cAMP formed min-1 mg-1 of protein, were exposed to free radicals formation of which was induced by Fe++/ascorbate.	Iron	198-202	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
3435503-6	1987	Highly purified sarcolemmal membranes, exhibiting an NaF-stimulated activity of 3.46 +/- 0.65 nmol cAMP formed min-1 mg-1 of protein, were exposed to free radicals formation of which was induced by Fe++/ascorbate.	Iron	198-202	CD59 molecule (CD59 blood group)	Homo sapiens	111-121
3473987-1	1987	Iron uptake from transferrin (Tf) by Friend erythroleukemia cells was studied before and after induction of the cells by dimethyl sulfoxide (DMSO) in culture.	Iron	0-4	transferrin	Homo sapiens	17-28
3473987-1	1987	Iron uptake from transferrin (Tf) by Friend erythroleukemia cells was studied before and after induction of the cells by dimethyl sulfoxide (DMSO) in culture.	Iron	0-4	transferrin	Homo sapiens	30-32
3473987-8	1987	Different efficiency of iron release from internalized Tf, accompanied by changes in cellular Tf kinetics is therefore proposed as a factor determining the rate of iron uptake by developing erythroid cells.	Iron	24-28	transferrin	Homo sapiens	55-57
3473987-8	1987	Different efficiency of iron release from internalized Tf, accompanied by changes in cellular Tf kinetics is therefore proposed as a factor determining the rate of iron uptake by developing erythroid cells.	Iron	24-28	transferrin	Homo sapiens	94-96
3473987-8	1987	Different efficiency of iron release from internalized Tf, accompanied by changes in cellular Tf kinetics is therefore proposed as a factor determining the rate of iron uptake by developing erythroid cells.	Iron	164-168	transferrin	Homo sapiens	55-57
3473987-8	1987	Different efficiency of iron release from internalized Tf, accompanied by changes in cellular Tf kinetics is therefore proposed as a factor determining the rate of iron uptake by developing erythroid cells.	Iron	164-168	transferrin	Homo sapiens	94-96
3790721-4	1987	A marked increase in cellular transferrin receptor expression occurred following exposure of cells to Tf-Ga. Tf-Ga inhibition of hemoglobin production could be reversed and hemoglobin production could be restored to normal by addition to the media of either transferrin-iron (Tf-Fe) or iron-pyridoxal isonicotinoyl hydrazone, a compound capable of supplying iron directly to reticulocytes for heme synthesis without transferrin as a mediator.	Iron	270-274	transferrin	Homo sapiens	30-41
3311219-5	1987	The decrease in cellular iron utilization seen with age might conceivably result from availability of heme independent of heme synthesis, as intracellular heme controls the cellular uptake of iron from transferrin.	Iron	25-29	transferrin	Homo sapiens	202-213
3311219-5	1987	The decrease in cellular iron utilization seen with age might conceivably result from availability of heme independent of heme synthesis, as intracellular heme controls the cellular uptake of iron from transferrin.	Iron	192-196	transferrin	Homo sapiens	202-213
3539227-7	1987	These findings support the concept that the hepatocyte has a central role in the uptake and storage of transferrin iron.	Iron	115-119	transferrin	Rattus norvegicus	103-114
3790721-4	1987	A marked increase in cellular transferrin receptor expression occurred following exposure of cells to Tf-Ga. Tf-Ga inhibition of hemoglobin production could be reversed and hemoglobin production could be restored to normal by addition to the media of either transferrin-iron (Tf-Fe) or iron-pyridoxal isonicotinoyl hydrazone, a compound capable of supplying iron directly to reticulocytes for heme synthesis without transferrin as a mediator.	Iron	286-290	transferrin	Homo sapiens	30-41
3107946-3	1987	While the uptake rate of induced cells is 26 atoms of iron per one transferrin receptor per hour, in non-induced cells, the rate is only 15 atoms of iron.	Iron	54-58	transferrin	Homo sapiens	67-78
3814518-0	1987	The role of mucosal transferrin in intestinal iron absorption.	Iron	46-50	transferrin	Homo sapiens	20-31
3107946-5	1987	By contrast, the rate of iron release from non-induced cells is slower and part of the iron bound to transferrin returns from the cell.	Iron	87-91	transferrin	Homo sapiens	101-112
3107946-8	1987	The differences in the efficacy of iron release from induced and non-induced erythroleukemia cells are, possibly, apart from the changes in the number of transferrin receptors, an additional factor involved in the control of cellular iron uptake.	Iron	234-238	transferrin	Homo sapiens	154-165
3107946-5	1987	By contrast, the rate of iron release from non-induced cells is slower and part of the iron bound to transferrin returns from the cell.	Iron	25-29	transferrin	Homo sapiens	101-112
3032605-7	1987	Chronic overloading of rats with iron results, on the opposite, in an increased rate of ethanol elimination, although alcohol dehydrogenase and catalase activities are reduced and cytochrome P-450 depleted in the liver of such iron-overloaded animals.	Iron	33-37	aldo-keto reductase family 1 member A1	Rattus norvegicus	118-139
3032605-7	1987	Chronic overloading of rats with iron results, on the opposite, in an increased rate of ethanol elimination, although alcohol dehydrogenase and catalase activities are reduced and cytochrome P-450 depleted in the liver of such iron-overloaded animals.	Iron	33-37	catalase	Rattus norvegicus	144-152
3032605-7	1987	Chronic overloading of rats with iron results, on the opposite, in an increased rate of ethanol elimination, although alcohol dehydrogenase and catalase activities are reduced and cytochrome P-450 depleted in the liver of such iron-overloaded animals.	Iron	33-37	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	180-196
3032605-7	1987	Chronic overloading of rats with iron results, on the opposite, in an increased rate of ethanol elimination, although alcohol dehydrogenase and catalase activities are reduced and cytochrome P-450 depleted in the liver of such iron-overloaded animals.	Iron	227-231	aldo-keto reductase family 1 member A1	Rattus norvegicus	118-139
3032605-7	1987	Chronic overloading of rats with iron results, on the opposite, in an increased rate of ethanol elimination, although alcohol dehydrogenase and catalase activities are reduced and cytochrome P-450 depleted in the liver of such iron-overloaded animals.	Iron	227-231	catalase	Rattus norvegicus	144-152
3032605-7	1987	Chronic overloading of rats with iron results, on the opposite, in an increased rate of ethanol elimination, although alcohol dehydrogenase and catalase activities are reduced and cytochrome P-450 depleted in the liver of such iron-overloaded animals.	Iron	227-231	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	180-196
3666279-0	1987	Unfolding of iron and copper complexes of human lactoferrin and transferrin.	Iron	13-17	transferrin	Homo sapiens	64-75
3148493-11	1987	Of the many compounds tested only catalase inhibits iron autoxidation in this buffer.	Iron	52-56	catalase	Homo sapiens	34-42
3148495-9	1987	In all these experimental conditions, iron oxidation is greatly reduced in the presence of mannitol, sorbitol and catalase.	Iron	38-42	catalase	Homo sapiens	114-122
2883038-0	1987	Release of iron from endosomes is an early step in the transferrin cycle.	Iron	11-15	transferrin	Homo sapiens	55-66
3666279-2	1987	Human lactoferrin and transferrin are capable of binding two iron or copper ions into specific binding sites in the presence of bicarbonate.	Iron	61-65	transferrin	Homo sapiens	22-33
3096888-1	1986	Neisseria meningitidis grown under iron-limiting conditions in vitro expresses additional iron-repressible outer membrane proteins (FeRPs).	Iron	35-39	FER tyrosine kinase pseudogene 1	Homo sapiens	132-137
3023366-0	1986	Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells.	Iron	44-48	transferrin	Homo sapiens	23-34
24214093-1	1986	Aluminium and fluoride were considered for their implications in bone disorders and iron for its competitive binding with aluminium to transferrin in serum.	Iron	84-88	transferrin	Homo sapiens	135-146
3624583-2	1987	In the initial experiments it was shown that the uptake of transferrin-bound iron by immature erythroid cells from marsupial and reptilian species occurs by receptor-mediated endocytosis as in other vertebrate animals.	Iron	77-81	transferrin	Homo sapiens	59-70
3573080-1	1987	Transferrin is the second most abundant plasma protein and functions to transport iron.	Iron	82-86	transferrin	Rattus norvegicus	0-11
3694713-3	1987	The receptor-mediated movement of transferrin across the blood-brain barrier suggests that the brain may derive its iron through the transcytosis of iron-loaded transferrin across the brain microvasculature.	Iron	116-120	transferrin	Rattus norvegicus	34-45
3694713-3	1987	The receptor-mediated movement of transferrin across the blood-brain barrier suggests that the brain may derive its iron through the transcytosis of iron-loaded transferrin across the brain microvasculature.	Iron	116-120	transferrin	Rattus norvegicus	161-172
3694713-3	1987	The receptor-mediated movement of transferrin across the blood-brain barrier suggests that the brain may derive its iron through the transcytosis of iron-loaded transferrin across the brain microvasculature.	Iron	149-153	transferrin	Rattus norvegicus	34-45
3694713-3	1987	The receptor-mediated movement of transferrin across the blood-brain barrier suggests that the brain may derive its iron through the transcytosis of iron-loaded transferrin across the brain microvasculature.	Iron	149-153	transferrin	Rattus norvegicus	161-172
3821483-1	1987	Induction of iron overload in mice using 1% (w/w) dietary carbonyl iron resulted in marked decreases in 1H and 31P NMR relaxation times.	Iron	13-17	inversion, Chr X, Harwell 1	Mus musculus	101-106
3821483-1	1987	Induction of iron overload in mice using 1% (w/w) dietary carbonyl iron resulted in marked decreases in 1H and 31P NMR relaxation times.	Iron	67-71	inversion, Chr X, Harwell 1	Mus musculus	101-106
3828435-3	1986	Iron-saturated and iron-free (apo-) transferrin use the same binding sites on the surface of the tubules, but the dissociation constant is about two times higher for apotransferrin than for iron-saturated transferrin.	Iron	0-4	transferrin	Rattus norvegicus	36-47
3828435-3	1986	Iron-saturated and iron-free (apo-) transferrin use the same binding sites on the surface of the tubules, but the dissociation constant is about two times higher for apotransferrin than for iron-saturated transferrin.	Iron	0-4	transferrin	Rattus norvegicus	169-180
3828435-3	1986	Iron-saturated and iron-free (apo-) transferrin use the same binding sites on the surface of the tubules, but the dissociation constant is about two times higher for apotransferrin than for iron-saturated transferrin.	Iron	19-23	transferrin	Rattus norvegicus	36-47
3828435-3	1986	Iron-saturated and iron-free (apo-) transferrin use the same binding sites on the surface of the tubules, but the dissociation constant is about two times higher for apotransferrin than for iron-saturated transferrin.	Iron	19-23	transferrin	Rattus norvegicus	169-180
3828435-3	1986	Iron-saturated and iron-free (apo-) transferrin use the same binding sites on the surface of the tubules, but the dissociation constant is about two times higher for apotransferrin than for iron-saturated transferrin.	Iron	190-194	transferrin	Rattus norvegicus	36-47
3828435-3	1986	Iron-saturated and iron-free (apo-) transferrin use the same binding sites on the surface of the tubules, but the dissociation constant is about two times higher for apotransferrin than for iron-saturated transferrin.	Iron	190-194	transferrin	Rattus norvegicus	169-180
3096888-1	1986	Neisseria meningitidis grown under iron-limiting conditions in vitro expresses additional iron-repressible outer membrane proteins (FeRPs).	Iron	90-94	FER tyrosine kinase pseudogene 1	Homo sapiens	132-137
3783029-4	1986	Because the higher iron content in smokers" macrophages may reflect increased internalization, the binding and uptake of iron-saturated transferrin was examined in cells from smokers and nonsmokers.	Iron	121-125	transferrin	Homo sapiens	136-147
3465751-7	1986	These studies, taken together, demonstrate that inhibition of cellular iron incorporation by transferrin-gallium is a prerequisite for inhibition of cellular proliferation.	Iron	71-75	transferrin	Homo sapiens	93-104
3465751-4	1986	The cytotoxicity of gallium is considerably enhanced by its binding to transferrin and cytotoxicity can be reversed by transferrin-iron but not by other transferrin forms.	Iron	131-135	transferrin	Homo sapiens	119-130
3465751-4	1986	The cytotoxicity of gallium is considerably enhanced by its binding to transferrin and cytotoxicity can be reversed by transferrin-iron but not by other transferrin forms.	Iron	131-135	transferrin	Homo sapiens	119-130
3783029-7	1986	Iron internalized by AM as iron 59 initially bound to transferrin was distributed to a cytoplasmic, largely ferritin-associated, pool more slowly in smokers than in nonsmokers, during a 24-hour incubation in vitro.	Iron	0-4	transferrin	Homo sapiens	54-65
3783029-7	1986	Iron internalized by AM as iron 59 initially bound to transferrin was distributed to a cytoplasmic, largely ferritin-associated, pool more slowly in smokers than in nonsmokers, during a 24-hour incubation in vitro.	Iron	27-31	transferrin	Homo sapiens	54-65
3801412-2	1986	In the present study it was found that, if this purified nonheme iron enzyme is slowly frozen in solution with glutathione and stored at -20 degrees C, it is fully active in the absence of activators if catalase is present to remove adventitious H2O2.	Iron	65-69	catalase	Homo sapiens	203-211
3768415-2	1986	The procedure involves chromatography of a detergent extract of placenta on immobilized iron-loaded transferrin.	Iron	88-92	transferrin	Homo sapiens	100-111
3779112-9	1986	As iron transfer cumulated linearly while transferrin release cumulated in an asymptotic manner, the capacity of transferrin to bind iron ions is exceeded roughly 100 times by molar equivalents of iron in the last absorbate fractions.	Iron	3-7	transferrin	Rattus norvegicus	113-124
3779112-9	1986	As iron transfer cumulated linearly while transferrin release cumulated in an asymptotic manner, the capacity of transferrin to bind iron ions is exceeded roughly 100 times by molar equivalents of iron in the last absorbate fractions.	Iron	133-137	transferrin	Rattus norvegicus	42-53
3779112-9	1986	As iron transfer cumulated linearly while transferrin release cumulated in an asymptotic manner, the capacity of transferrin to bind iron ions is exceeded roughly 100 times by molar equivalents of iron in the last absorbate fractions.	Iron	133-137	transferrin	Rattus norvegicus	113-124
3779112-9	1986	As iron transfer cumulated linearly while transferrin release cumulated in an asymptotic manner, the capacity of transferrin to bind iron ions is exceeded roughly 100 times by molar equivalents of iron in the last absorbate fractions.	Iron	133-137	transferrin	Rattus norvegicus	42-53
3779112-9	1986	As iron transfer cumulated linearly while transferrin release cumulated in an asymptotic manner, the capacity of transferrin to bind iron ions is exceeded roughly 100 times by molar equivalents of iron in the last absorbate fractions.	Iron	133-137	transferrin	Rattus norvegicus	113-124
3533647-2	1986	In serving this function they exchange iron bidirectionally with the plasma iron transport protein transferrin (Tf).	Iron	39-43	transferrin	Homo sapiens	99-110
3533647-2	1986	In serving this function they exchange iron bidirectionally with the plasma iron transport protein transferrin (Tf).	Iron	39-43	transferrin	Homo sapiens	112-114
3490395-3	1986	Purified iron-saturated human transferrin (TF) suppressed release of GM-CSF only from the T4+ subset of lymphocytes.	Iron	9-13	transferrin	Homo sapiens	30-41
3490395-3	1986	Purified iron-saturated human transferrin (TF) suppressed release of GM-CSF only from the T4+ subset of lymphocytes.	Iron	9-13	transferrin	Homo sapiens	43-45
3533647-3	1986	Iron uptake involves binding of the iron-Tf complex to cell membrane receptors and endocytosis into low-density vesicles, where the iron is released from its carrier protein before the Tf is returned undegraded to the extracellular medium.	Iron	0-4	transferrin	Homo sapiens	41-43
3533647-3	1986	Iron uptake involves binding of the iron-Tf complex to cell membrane receptors and endocytosis into low-density vesicles, where the iron is released from its carrier protein before the Tf is returned undegraded to the extracellular medium.	Iron	36-40	transferrin	Homo sapiens	41-43
3533647-3	1986	Iron uptake involves binding of the iron-Tf complex to cell membrane receptors and endocytosis into low-density vesicles, where the iron is released from its carrier protein before the Tf is returned undegraded to the extracellular medium.	Iron	132-136	transferrin	Homo sapiens	41-43
3533647-4	1986	Two components of the iron uptake process can be distinguished, one saturable at low concentrations of diferric Tf and the other not saturable by increasing the Tf concentration.	Iron	22-26	transferrin	Homo sapiens	112-114
3533647-4	1986	Two components of the iron uptake process can be distinguished, one saturable at low concentrations of diferric Tf and the other not saturable by increasing the Tf concentration.	Iron	22-26	transferrin	Homo sapiens	161-163
3533647-7	1986	Within the cell iron from all sources enters one or more transit pools, where it is available for exchange with the iron storage protein Fn, and for release from the cell to plasma Tf or to iron chelators administered therapeutically or experimentally.	Iron	16-20	transferrin	Homo sapiens	181-183
3541387-7	1986	It is then necessary to establish the parenchymal nature of the iron overload by showing an elevated transferrin saturation and, if elevated, the more definitive liver biopsy should be done.	Iron	64-68	transferrin	Homo sapiens	101-112
3810041-5	1986	Iron, supplied by a route alternative to Tf-to suramin-suppressed U-937 cells, reinitiated DNA synthesis and cell division, although at a lower level than in control cells.	Iron	0-4	transferrin	Homo sapiens	41-43
3772222-0	1986	Iron release from transferrin: synergistic interaction between adenosine triphosphate and an ammonium sulfate fraction of hemolysate.	Iron	0-4	transferrin	Homo sapiens	18-29
3772222-1	1986	In previous work we have shown that red cell hemolysates, at neutral pH, will release iron from transferrin; with molecular sieve chromatography, that activity separated into low molecular weight and high molecular weight components, both susceptible to destruction by phosphatases.	Iron	86-90	transferrin	Homo sapiens	96-107
3772222-4	1986	ATP, as well as adenosine diphosphate and 2,3-diphosphoglyceric acid, interacts synergistically with the ammonium sulfate hemolysate fraction to promote iron release from transferrin.	Iron	153-157	transferrin	Homo sapiens	171-182
2877685-3	1986	Since a good correlation was found between the rate of iron uptake and the number of coated pits, but not between the rate of transferrin recycling and the coated pit count, it is likely that coated pit formation is necessary for the removal of iron from transferrin.	Iron	245-249	transferrin	Homo sapiens	255-266
3759950-0	1986	The influence of uncoordinated histidines on iron release from transferrin.	Iron	45-49	transferrin	Homo sapiens	63-74
3759950-2	1986	Histidine residues that influence the chelate-mediated removal of iron from transferrin have been investigated.	Iron	66-70	transferrin	Homo sapiens	76-87
3779881-8	1986	About 15% of the remaining cytochrome P-450 existed as a cyt.-P-450-Fe(III)-C6H5 complex, a new example of cytochrome P-450-Fe-metabolite complex which is stable in vivo.	Iron	68-70	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	27-43
3779881-8	1986	About 15% of the remaining cytochrome P-450 existed as a cyt.-P-450-Fe(III)-C6H5 complex, a new example of cytochrome P-450-Fe-metabolite complex which is stable in vivo.	Iron	68-70	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	107-123
3020022-1	1986	NADPH-cytochrome P-450 reductase-catalyzed reduction of paraquat promoted the release of iron from ferritin.	Iron	89-93	cytochrome p450 oxidoreductase	Homo sapiens	0-32
3789818-4	1986	Significant correlations were found in the patient group between (PMN) iron and the circulating levels of transferrin, total iron, and lactoferrin (p less than 0.05).	Iron	71-75	transferrin	Homo sapiens	106-117
3789818-6	1986	Platelet iron correlated with transferrin (p less than 0.01) but not with the other iron binding proteins.	Iron	9-13	transferrin	Homo sapiens	30-41
3463412-7	1986	These results suggest that stationary cells subcultured in fresh medium undergo a depletion of their intracellular iron pool, which in turn may represent the stimulus triggering TRF receptor synthesis.	Iron	115-119	transferrin	Homo sapiens	178-181
3463412-8	1986	This hypothesis is supported by two observations: both the depletion of this pool and the rise in TRF receptor synthesis are more marked in the absence than in the presence of serum; addition of excess exogenous iron fully inhibits the rise of TRF receptor synthesis in cells subcultured with fresh medium and serum.	Iron	212-216	transferrin	Homo sapiens	98-101
2428547-0	1986	Microheterogeneity of human transferrin as revealed by agarose gel electrophoresis with an iron-specific stain.	Iron	91-95	transferrin	Homo sapiens	28-39
3463412-8	1986	This hypothesis is supported by two observations: both the depletion of this pool and the rise in TRF receptor synthesis are more marked in the absence than in the presence of serum; addition of excess exogenous iron fully inhibits the rise of TRF receptor synthesis in cells subcultured with fresh medium and serum.	Iron	212-216	transferrin	Homo sapiens	244-247
3017805-8	1986	Our results suggest that iron deficiency is accompanied by an increase in transferrin receptors in duodenal absorptive cells, and the genetic lesion in hemochromatosis does not involve an increase in transferrin receptors in the intestinal mucosa compared with subjects with normal iron stores.	Iron	25-29	transferrin	Homo sapiens	74-85
3489614-4	1986	Iron status was defined as a function of percentage transferrin saturation (%TS) and total iron-binding capacity (TIBC).	Iron	0-4	transferrin	Homo sapiens	52-63
3097242-8	1986	We conclude that the proposed transferrin method is more reliable and easier to perform than presently available total iron binding capacity methods.	Iron	119-123	transferrin	Homo sapiens	30-41
3576049-4	1986	After the withdrawal of iron therapy, directly correlated ferritin levels and percentage transferrin saturation decreased slowly, except in carriers of HLA-A3 antigens and in polytransfused patients.	Iron	24-28	transferrin	Homo sapiens	89-100
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	46-48	telomerase RNA component	Homo sapiens	49-52
3749034-0	1986	The effect of transferrin saturation on internal iron exchange.	Iron	49-53	transferrin	Homo sapiens	14-25
3749034-3	1986	Radioiron introduced into the lumen of the gut as ferrous sulfate and as transferrin-bound iron was absorbed about half as well in iron-infused animals, and absorbed iron was localized in the liver.	Iron	5-9	transferrin	Homo sapiens	73-84
3749034-3	1986	Radioiron introduced into the lumen of the gut as ferrous sulfate and as transferrin-bound iron was absorbed about half as well in iron-infused animals, and absorbed iron was localized in the liver.	Iron	91-95	transferrin	Homo sapiens	73-84
3749034-3	1986	Radioiron introduced into the lumen of the gut as ferrous sulfate and as transferrin-bound iron was absorbed about half as well in iron-infused animals, and absorbed iron was localized in the liver.	Iron	91-95	transferrin	Homo sapiens	73-84
3749034-4	1986	The similar absorption of transferrin-bound iron suggested that absorption of ferrous iron occurred via the mucosal cell and did not enter by diffusion.	Iron	44-48	transferrin	Homo sapiens	26-37
3019155-2	1986	In experiments lasting 60-90 min, rat asialotransferrin delivered a three to four times larger fraction of the Fe dose to the liver than rat transferrin.	Iron	111-113	transferrin	Rattus norvegicus	44-55
3019155-5	1986	In all cases, rat asialotransferrin delivered Fe to the liver at rates comparable with those seen with rat transferrin.	Iron	46-48	transferrin	Rattus norvegicus	24-35
3019155-7	1986	These findings suggest that the enhanced hepatic uptake of Fe from rat asialotransferrin is mediated by simultaneous binding of the ligand both through its glycan and transferrin receptor affinity site.	Iron	59-61	transferrin	Rattus norvegicus	77-88
3019155-9	1986	The data suggest that deposition of a significant fraction of Fe in rat liver from rat transferrin is likely to take place by a mechanism not involving transferrin receptors.	Iron	62-64	transferrin	Rattus norvegicus	87-98
3767994-2	1986	We now show that cells can reduce the iron in diferric transferrin at the cell surface and that this reduction reaction depends on the transferrin receptor as well as the transmembrane electron transport system.	Iron	38-42	transferrin	Homo sapiens	55-66
3767994-2	1986	We now show that cells can reduce the iron in diferric transferrin at the cell surface and that this reduction reaction depends on the transferrin receptor as well as the transmembrane electron transport system.	Iron	38-42	transferrin	Homo sapiens	135-146
3778666-9	1986	Electron spin resonance (ESR) measurements confirmed that Fe.HTr (citrate) and Fe.HTr (ceruloplasmin) were saturated with Fe.	Iron	58-60	telomerase RNA component	Homo sapiens	61-64
3778666-11	1986	Dialysis against H2O caused Fe.HTr (citrate), but not Fe.HTr (ceruloplasmin), to lose absorbance at 465 nm.	Iron	28-30	telomerase RNA component	Homo sapiens	31-34
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	46-48	telomerase RNA component	Homo sapiens	163-166
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	46-48	telomerase RNA component	Homo sapiens	163-166
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	160-162	telomerase RNA component	Homo sapiens	49-52
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	160-162	telomerase RNA component	Homo sapiens	163-166
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	160-162	telomerase RNA component	Homo sapiens	163-166
3778666-17	1986	The two Fe.HTr products may differ, conceivably, in their abilities to transfer Fe to cells.	Iron	8-10	telomerase RNA component	Homo sapiens	11-14
3743768-4	1986	The occurrence of both gastrin and gastric transferrin in porcine gastric mucosa and lumen suggests a novel synergistic role for the observed interaction in the uptake of dietary iron.	Iron	179-183	transferrin	Homo sapiens	43-54
3490355-3	1986	During endotoxin-induced ocular inflammation the copper (Cu) and iron (Fe) concentrations of both the aqueous and vitreous humors increased, most likely due to the influx of their plasma binding proteins, ceruloplasmin (Cu) and transferrin (Fe).	Iron	71-73	ceruloplasmin	Oryctolagus cuniculus	205-218
3733737-0	1986	Characterization of non-transferrin-bound iron clearance by rat liver.	Iron	42-46	transferrin	Rattus norvegicus	24-35
3758939-7	1986	Chase experiments showed that the internalized transferrin donated all of its iron to the cell and was then released in a biphasic manner which was dependent on the time of preincubation with radiolabeled transferrin.	Iron	78-82	transferrin	Rattus norvegicus	47-58
3758939-11	1986	The second process is nonsaturable up to a transferrin concentration of at least 6 microM but like the specific process, also leads to accumulation of iron in excess of transferrin.	Iron	151-155	transferrin	Rattus norvegicus	43-54
3749786-6	1986	Five subjects had iron deficiency based on serum iron and transferrin but no anaemia.	Iron	18-22	transferrin	Homo sapiens	58-69
3733737-9	1986	Because clearance is highly efficient, increased levels of non-transferrin-bound iron in plasma may present the liver with an obligatory iron load resulting in progressive accumulation and toxicity.	Iron	137-141	transferrin	Rattus norvegicus	63-74
3733737-1	1986	Recent evidence suggests that the hepatic iron-loading characteristic of hemochromatosis may result in part from efficient hepatic clearance of non-transferrin-bound iron, which is increased in this disorder.	Iron	42-46	transferrin	Rattus norvegicus	148-159
3733737-1	1986	Recent evidence suggests that the hepatic iron-loading characteristic of hemochromatosis may result in part from efficient hepatic clearance of non-transferrin-bound iron, which is increased in this disorder.	Iron	166-170	transferrin	Rattus norvegicus	148-159
3733737-3	1986	We therefore studied hepatic uptake of non-transferrin-bound iron in the single-pass perfused rat liver under varying conditions.	Iron	61-65	transferrin	Rattus norvegicus	43-54
3733737-9	1986	Because clearance is highly efficient, increased levels of non-transferrin-bound iron in plasma may present the liver with an obligatory iron load resulting in progressive accumulation and toxicity.	Iron	81-85	transferrin	Rattus norvegicus	63-74
3017216-3	1986	We now report that, in the presence of NADPH-cytochrome P-450 reductase, these drugs undergo redox cycling to generate superoxide which mediates a slow, reductive release of iron from ferritin, the major intracellular iron storage protein.	Iron	174-178	cytochrome p450 oxidoreductase	Homo sapiens	39-71
3530028-0	1986	Depression of iron uptake from transferrin by isolated hepatocytes in the presence of ethanol is a pH-dependent consequence of ethanol metabolism.	Iron	14-18	transferrin	Rattus norvegicus	31-42
3530028-1	1986	Incubation of freshly isolated rat hepatocytes with highly purified radiolabeled rat transferrin in weakly buffered medium in the presence of 10 mM ethanol resulted in a marked diminution of iron uptake by these cells, associated with a greater pH depression than in ethanol-free control studies.	Iron	191-195	transferrin	Rattus norvegicus	85-96
3530028-2	1986	This effect on iron uptake persisted, even when the cells were preincubated for 90 min with ethanol before the addition of transferrin.	Iron	15-19	transferrin	Rattus norvegicus	123-134
3530028-3	1986	Increasing the buffering capacity of the system or the addition of a metabolic inhibitor of alcohol dehydrogenase (4-methylpyrazole) returned iron uptake to control values.	Iron	142-146	aldo-keto reductase family 1 member A1	Rattus norvegicus	92-113
3530028-7	1986	It is suggested that, in the light of current understanding of transferrin recycling by other cell types, the disturbances of iron homeostasis observed in alcoholics can be partially accounted for by alterations in their acid-base metabolism.	Iron	126-130	transferrin	Rattus norvegicus	63-74
3017216-3	1986	We now report that, in the presence of NADPH-cytochrome P-450 reductase, these drugs undergo redox cycling to generate superoxide which mediates a slow, reductive release of iron from ferritin, the major intracellular iron storage protein.	Iron	218-222	cytochrome p450 oxidoreductase	Homo sapiens	39-71
3013860-0	1986	Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane.	Iron	28-32	insulin	Homo sapiens	0-7
3015988-10	1986	Iron uptake experiments show an iron donating hierarchy where human greater than horse greater than calf, suggesting that the rate of iron uptake depends on the affinity of receptor for transferrin.	Iron	0-4	serotransferrin	Bos taurus	186-197
3015988-10	1986	Iron uptake experiments show an iron donating hierarchy where human greater than horse greater than calf, suggesting that the rate of iron uptake depends on the affinity of receptor for transferrin.	Iron	32-36	serotransferrin	Bos taurus	186-197
3015988-10	1986	Iron uptake experiments show an iron donating hierarchy where human greater than horse greater than calf, suggesting that the rate of iron uptake depends on the affinity of receptor for transferrin.	Iron	134-138	serotransferrin	Bos taurus	186-197
3730295-1	1986	There is evidence in experimental animals that transferrin, produced either by gastrointestinal cells or derived from bile, mediates the luminal absorption of iron.	Iron	159-163	transferrin	Homo sapiens	47-58
3730295-3	1986	Achlorhydric subjects were chosen to ensure that the iron transferrin complex did not dissociate in the stomach.	Iron	53-57	transferrin	Homo sapiens	58-69
3019385-0	1986	Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen.	Iron	0-4	collagen type I alpha 2 chain	Homo sapiens	129-147
3741545-5	1986	In fact, DF by reducing liver iron levels produced a smaller decrease of the target enzyme (PCL) and a concomitant smaller induction of ALA-S.	Iron	30-34	5'-aminolevulinate synthase 1	Rattus norvegicus	136-141
3013860-1	1986	Insulin stimulates the accumulation of iron by isolated fat cells by increasing the uptake of diferric transferrin.	Iron	39-43	insulin	Homo sapiens	0-7
3013860-1	1986	Insulin stimulates the accumulation of iron by isolated fat cells by increasing the uptake of diferric transferrin.	Iron	39-43	transferrin	Homo sapiens	103-114
3013860-11	1986	We conclude that insulin stimulates fat cell iron uptake by a mechanism that may involve the redistribution of transferrin receptors from an internal membrane compartment (low density microsomes) to the cell surface (plasma membrane).	Iron	45-49	insulin	Homo sapiens	17-24
3013860-11	1986	We conclude that insulin stimulates fat cell iron uptake by a mechanism that may involve the redistribution of transferrin receptors from an internal membrane compartment (low density microsomes) to the cell surface (plasma membrane).	Iron	45-49	transferrin	Homo sapiens	111-122
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	35-46
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	134-145
3800875-8	1986	When livers were perfused with various concentrations of transferrin the total uptakes of both iron and transferrin and incorporation into their subcellular fractions were curvilinear, increasing with transferrin concentrations up to at least 10 microM.	Iron	95-99	transferrin	Rattus norvegicus	57-68
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	53-57	transferrin	Rattus norvegicus	35-46
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	53-57	transferrin	Rattus norvegicus	134-145
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	53-57	transferrin	Rattus norvegicus	134-145
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	53-57	transferrin	Rattus norvegicus	134-145
3015607-9	1986	Iron chelators inhibited the P-450-dependent lipid peroxidation, whereas iron chelate interacted with NADPH-cytochrome-P-450 reductase in the membranes giving rise to reductase-dependent lipid peroxidation.	Iron	73-77	cytochrome p450 oxidoreductase	Homo sapiens	102-134
3013902-1	1986	Specific binding of ferric bovine transferrin to the human transferrin receptor was investigated using K562 cells propagated in serum-free medium without transferrin supplemented with 10(-5) elemental iron.	Iron	201-205	serotransferrin	Bos taurus	34-45
3013902-1	1986	Specific binding of ferric bovine transferrin to the human transferrin receptor was investigated using K562 cells propagated in serum-free medium without transferrin supplemented with 10(-5) elemental iron.	Iron	201-205	transferrin	Homo sapiens	59-70
3731491-0	1986	A non-random distribution of transferrin iron in fresh human sera.	Iron	41-45	transferrin	Homo sapiens	29-40
3732592-0	1986	Transferrin: a study of the iron-binding sites using extended X-ray absorption fine structure and anomalous dispersion techniques.	Iron	28-32	transferrin	Homo sapiens	0-11
3459151-4	1986	This increase in transferrin gene expression resulted in a corresponding increase in serum total-iron-binding capacity.	Iron	97-101	transferrin	Rattus norvegicus	17-28
3459151-7	1986	The small intestine had no detectable transferrin mRNA in either normal or iron-deficient rats; however, transferrin protein was present, and its level was 2-fold higher in the iron-deficient group.	Iron	177-181	transferrin	Rattus norvegicus	105-116
3719094-0	1986	Nonrandom distribution of iron in circulating human transferrin.	Iron	26-30	transferrin	Homo sapiens	52-63
3719094-1	1986	By combining the urea gel electrophoresis technique of Makey and Seal with Western immunoblotting, a method has been developed for analyzing the distribution of iron between the two sites of circulating human transferrin.	Iron	161-165	transferrin	Homo sapiens	209-220
3089853-4	1986	As shown previously for transferrin, the inhibitory effect of brain extract at high concentrations was relieved by the addition of iron.	Iron	131-135	transferrin	Homo sapiens	24-35
3742644-3	1986	Each of the 10 hydrocarbons produced a Type I spectral change, indicative of a low to high spin transition of the haem iron of cytochrome P-450.	Iron	119-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	127-143
3459151-2	1986	We quantitated transferrin mRNA in a variety of tissues from normal and iron-deficient rats and found that the level of transferrin mRNA in normal rat liver was about 6500 molecules per cell, while the level in iron-deficient animals was 2.4-fold higher.	Iron	72-76	transferrin	Rattus norvegicus	120-131
3459151-2	1986	We quantitated transferrin mRNA in a variety of tissues from normal and iron-deficient rats and found that the level of transferrin mRNA in normal rat liver was about 6500 molecules per cell, while the level in iron-deficient animals was 2.4-fold higher.	Iron	211-215	transferrin	Rattus norvegicus	120-131
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	134-145
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	134-145
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	35-46
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	134-145
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	134-145
3800875-15	1986	It is concluded that the uptake of transferrin-bound iron by the liver of the rat results from endocytosis by hepatocytes of the iron-transferrin complex into low-density vesicles followed by release of iron from the transferrin and recycling of the transferrin to the extracellular medium.	Iron	129-133	transferrin	Rattus norvegicus	134-145
3008852-2	1986	In this paper, we demonstrate that the monoclonal antibody 42/6 to human transferrin receptor inhibits iron uptake in the human leukemic K562 cell line and suppresses hemoglobin accumulation in K562 cells induced to erythroid differentiation by butyric acid.	Iron	103-107	transferrin	Homo sapiens	73-84
3790074-1	1986	The effect of the iron chelator, desferrioxamine, on transferrin binding, growth rates and the cell cycle was investigated in the human leukaemic cell line, K562.	Iron	18-22	transferrin	Homo sapiens	53-64
3790074-9	1986	Desferrioxamine may increase transferrin receptors in two ways: by chelating a regulatory pool of iron within the cell, and by arresting cells in S phase when receptors are maximally expressed.	Iron	98-102	serotransferrin	Bos taurus	29-40
3013312-5	1986	The reduction of the iron may occur via ligand-induced oxidation of the axially bound thiolate of cytochrome P-450.	Iron	21-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-114
3964300-3	1986	In the case of iron-loaded transferrin, reactions with carbodiimides were in phosphate-buffered saline (pH 7.5) to prevent loss of iron from the protein.	Iron	15-19	serotransferrin	Bos taurus	27-38
3008845-0	1986	The effects of salts and amino group modification on the iron binding domains of transferrin.	Iron	57-61	transferrin	Homo sapiens	81-92
3008845-1	1986	The origins of the effects of salts on the properties of the iron binding sites of transferrin have been investigated.	Iron	61-65	transferrin	Homo sapiens	83-94
3735435-1	1986	An iron-containing fragment (Mr approximately 39,000) of rabbit serum transferrin has been crystallized from a solution of 25% (w/v) polyethylene glycol 6000, 50 mM-disodium piperazine-N,N"bis(2-ethanesulphonate) adjusted to pH 6.0 at 4 degrees C. The space group is P3(1)21 (or the enantiomorph) with a = b = 66.8(1) A, c = 137.5(3) A and Z = 6.	Iron	3-7	transferrin	Homo sapiens	70-81
3964300-3	1986	In the case of iron-loaded transferrin, reactions with carbodiimides were in phosphate-buffered saline (pH 7.5) to prevent loss of iron from the protein.	Iron	131-135	serotransferrin	Bos taurus	27-38
3457008-3	1986	Overnight exposure to iron donors such as diferric transferrin or hemin increases the ferritin level 2-4- or 6-8-fold above that of the control, respectively.	Iron	22-26	transferrin	Homo sapiens	51-62
3007467-12	1986	The kinetics of iron removal from Fe3+-transferrin-CO2-3 by PPi are consistent with a rate-limiting conformational change in the protein as proposed earlier.	Iron	16-20	transferrin	Homo sapiens	39-50
3457008-4	1986	Treatment with the anti-human transferrin receptor antibody, OKT9 (which reduces the iron uptake by decreasing the number of transferrin receptors) lowers the ferritin level by approximately 70-80% with respect to the control.	Iron	85-89	transferrin	Homo sapiens	30-41
3457008-7	1986	Iron released from transferrin appears to distribute to ferritin according to a partition function; the entering load going into ferritin is set for a given ferritin level over a wide range of actual amounts of iron delivered.	Iron	0-4	transferrin	Homo sapiens	19-30
3457008-7	1986	Iron released from transferrin appears to distribute to ferritin according to a partition function; the entering load going into ferritin is set for a given ferritin level over a wide range of actual amounts of iron delivered.	Iron	211-215	transferrin	Homo sapiens	19-30
3013043-12	1986	These observations indicate that GPBP/transferrin-induced adherence of granulocytes to pollen grains is a hitherto unrecognized property of transferrin which appears unrelated to iron transport or the conventional transferrin receptor.	Iron	179-183	transferrin	Homo sapiens	38-49
3755593-3	1986	It has the ability to catalyse the oxidative incorporation of iron into transferrin at very low Fe2+ and O2 concentrations.	Iron	62-66	transferrin	Rattus norvegicus	72-83
3697729-1	1986	Recent studies have demonstrated receptors in the nervous system for transferrin, the iron binding and transport protein in the blood.	Iron	86-90	transferrin	Rattus norvegicus	69-80
3004704-9	1986	Studies using HL60 cells grown with soluble iron in lieu of TF showed that changes in TF binding sites and TF uptake were not secondary to growth inhibition.	Iron	44-48	transferrin	Homo sapiens	86-88
3004704-9	1986	Studies using HL60 cells grown with soluble iron in lieu of TF showed that changes in TF binding sites and TF uptake were not secondary to growth inhibition.	Iron	44-48	transferrin	Homo sapiens	86-88
3083076-0	1986	Non-transferrin-bound iron in long-term transfusion in children with congenital anemias.	Iron	22-26	transferrin	Homo sapiens	4-15
3083076-1	1986	Non-transferrin-bound iron (NTBI), a potentially toxic compound, is increased in the serum of patients with iron overload and fully saturated transferrin.	Iron	22-26	transferrin	Homo sapiens	4-15
3083076-1	1986	Non-transferrin-bound iron (NTBI), a potentially toxic compound, is increased in the serum of patients with iron overload and fully saturated transferrin.	Iron	22-26	transferrin	Homo sapiens	142-153
3083076-1	1986	Non-transferrin-bound iron (NTBI), a potentially toxic compound, is increased in the serum of patients with iron overload and fully saturated transferrin.	Iron	108-112	transferrin	Homo sapiens	4-15
3715363-0	1986	Uptake of iron from transferrin by isolated hepatocytes.	Iron	10-14	transferrin	Rattus norvegicus	20-31
3715363-2	1986	The mechanism by which utilization of transferrin-bound iron is linked with cellular metabolism has been studied in isolated rat hepatocytes.	Iron	56-60	transferrin	Rattus norvegicus	38-49
3955059-11	1986	When ferrochelatase activity was measured by pyridine hemochromogen, identical results were observed in iron-deficient and control animals but decreased by 45% in iron-overloaded animals.	Iron	104-108	ferrochelatase	Rattus norvegicus	5-19
3955059-11	1986	When ferrochelatase activity was measured by pyridine hemochromogen, identical results were observed in iron-deficient and control animals but decreased by 45% in iron-overloaded animals.	Iron	163-167	ferrochelatase	Rattus norvegicus	5-19
3697729-9	1986	The presence of Tf in oligodendrocytes implies that these neuroglia are involved in iron mobilization and storage in the CNS.	Iron	84-88	transferrin	Rattus norvegicus	16-18
3697729-10	1986	Stored quantities of iron and the ability to mobilize the iron through stored transferrin may be the reason for the extreme dietary restrictions necessary to induce iron-deficient CNS disorders.	Iron	21-25	transferrin	Rattus norvegicus	78-89
3697729-10	1986	Stored quantities of iron and the ability to mobilize the iron through stored transferrin may be the reason for the extreme dietary restrictions necessary to induce iron-deficient CNS disorders.	Iron	58-62	transferrin	Rattus norvegicus	78-89
3008856-1	1986	Changes observed in CD- and absorption spectra of cytochrome c solubilized in reversed micelles AOT showed significant structural transformations of protein in the region of the active centre and particularly revealed a replacement of the sixth ligand of heme iron.	Iron	260-264	cytochrome c, somatic	Homo sapiens	50-62
3947682-9	1986	Incubation at 37 degrees C with 59Fe-labeled transferrin indicated that all iron uptake occurs through high-affinity binding.	Iron	76-80	transferrin	Homo sapiens	45-56
3005277-8	1986	The action of iron salts and chelators is specific for transferrin receptors, since the expression of other membrane markers of activated human T-lymphocytes (interleukin-2 receptor, insulin receptor, and HLA-DR antigen) is not modified by treatment with iron or picolinic acid.	Iron	14-18	transferrin	Homo sapiens	55-66
3005277-9	1986	These observations suggest that expression of transferrin receptors in activated T-lymphocytes is specifically modulated by their intracellular iron level, rather than their proliferative rate.	Iron	144-148	transferrin	Homo sapiens	46-57
3005277-11	1986	On the basis of these results, we suggest a three-step model: (a) in resting T-lymphocytes, the gene for transferrin receptor is apparently "closed," in that it is not expressed under both normal conditions and following iron deprivation.	Iron	221-225	transferrin	Homo sapiens	105-116
3005277-12	1986	(b) After mitogen stimulus, T-lymphocytes are reprogrammed into cell cycle progression, which necessarily entails synthesis of transferrin receptors (c) Expression of these receptors is modulated by the intracellular iron level, rather than the rate of proliferation per se.	Iron	217-221	transferrin	Homo sapiens	127-138
2874839-4	1986	Transferrin, a major serum glycoprotein which transports iron into cells, enters cells by this pathway.	Iron	57-61	transferrin	Homo sapiens	0-11
2874839-8	1986	Transferrin has a different fate: in endosomes iron dissociates from transferrin but apotransferrin remains bound to its receptor because of its high affinity for the receptor at acid pH.	Iron	47-51	transferrin	Homo sapiens	0-11
3081063-7	1986	Reticulocyte incubation studies demonstrated an unimpaired uptake of the transferrin-iron-receptor complex but a marked reduction in iron accumulation.	Iron	85-89	transferrin	Rattus norvegicus	73-84
3954965-0	1986	Intracellular forms of iron during transferrin iron uptake by mitogen-stimulated human lymphocytes.	Iron	23-27	transferrin	Homo sapiens	35-46
3954965-0	1986	Intracellular forms of iron during transferrin iron uptake by mitogen-stimulated human lymphocytes.	Iron	47-51	transferrin	Homo sapiens	35-46
3954965-1	1986	Transferrin receptors expressed by mitogen stimulated human lymphocytes mediate the uptake of transferrin iron into haem, ferritin and a non-haem, non-ferritin component.	Iron	106-110	transferrin	Homo sapiens	0-11
3954965-1	1986	Transferrin receptors expressed by mitogen stimulated human lymphocytes mediate the uptake of transferrin iron into haem, ferritin and a non-haem, non-ferritin component.	Iron	106-110	transferrin	Homo sapiens	94-105
3081063-8	1986	The diferric transferrin molecule, when it did give up iron within the cell, released both of its iron atoms so that only apotransferrin was returned to the media.	Iron	55-59	transferrin	Rattus norvegicus	13-24
3081063-8	1986	The diferric transferrin molecule, when it did give up iron within the cell, released both of its iron atoms so that only apotransferrin was returned to the media.	Iron	98-102	transferrin	Rattus norvegicus	13-24
2419904-8	1986	Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.	Iron	76-80	transferrin	Homo sapiens	134-145
3512430-6	1986	In the presence of polymorphs the addition of Fe3+ to give 60% saturation of the transferrin with iron led to rapid growth after a long delay (19 h).	Iron	98-102	transferrin	Homo sapiens	81-92
3512430-7	1986	Progressive increases in saturation above 60% gave correspondingly quicker growth, suggesting that the higher the saturation of transferrin, the easier it is for the bacteria to acquire iron.	Iron	186-190	transferrin	Homo sapiens	128-139
3013197-5	1986	Second, allopurinol was found to act as an electron transfer agent from ferrous iron to ferric cytochrome c.	Iron	72-84	cytochrome c, somatic	Homo sapiens	95-107
3699915-3	1986	The tight binding of aluminium to transferrin may play a role in the development of microcytic hypochromic anaemia in aluminium intoxicated patients despite the presence of adequate iron.	Iron	182-186	transferrin	Homo sapiens	34-45
3005341-4	1986	OKT9 treatment also leads to a decrease in the total number of receptors participating in the transferrin cycle for cellular iron uptake.	Iron	125-129	transferrin	Homo sapiens	94-105
3964644-7	1986	The results indicate that the ratio of iron binding constants for lactoferrin and transferrin is likely in the range of 50-90.	Iron	39-43	transferrin	Homo sapiens	82-93
3954760-6	1986	It appears that oxidation of NADH by the transmembrane electron transport using ferricyanide or iron transferrin as external electron acceptors is sufficient to stimulate growth in HeLa cells.	Iron	96-100	transferrin	Homo sapiens	101-112
3948880-11	1986	On the basis of our results we suggest that, at low extracellular transferrin concentration, iron uptake by the liver involves endocytosis of the transferrin protein.	Iron	93-97	transferrin	Rattus norvegicus	66-77
3948880-11	1986	On the basis of our results we suggest that, at low extracellular transferrin concentration, iron uptake by the liver involves endocytosis of the transferrin protein.	Iron	93-97	transferrin	Rattus norvegicus	146-157
3948880-14	1986	The iron-depleted transferrin molecule would then be returned to the extracellular medium during the recycling of the plasma membrane.	Iron	4-8	transferrin	Rattus norvegicus	18-29
3949004-0	1986	Binding of transferrin-iron by adriamycin at acidic pH.	Iron	23-27	transferrin	Homo sapiens	11-22
3949004-1	1986	It is shown that adriamycin is able to chelate iron released from iron-loaded serum transferrin in the pH range from 6.5-4.1.	Iron	47-51	transferrin	Homo sapiens	84-95
3949004-1	1986	It is shown that adriamycin is able to chelate iron released from iron-loaded serum transferrin in the pH range from 6.5-4.1.	Iron	66-70	transferrin	Homo sapiens	84-95
3949004-2	1986	The kinetics of iron transfer to free adriamycin and to adriamycin covalently attached to the transferrin has been determined.	Iron	16-20	transferrin	Homo sapiens	94-105
3949004-3	1986	The results show that adriamycin, if introduced into intracellular acidic compartments, could function as acceptor for transferrin-iron.	Iron	131-135	transferrin	Homo sapiens	119-130
3947549-0	1986	Interaction of transferrin with iron-loaded rat peritoneal macrophages.	Iron	32-36	transferrin	Rattus norvegicus	15-26
3005367-1	1986	Transferrin (Tf) is a growth factor that transports iron in plasma.	Iron	52-56	transferrin	Homo sapiens	0-11
3005367-1	1986	Transferrin (Tf) is a growth factor that transports iron in plasma.	Iron	52-56	transferrin	Homo sapiens	13-15
25291546-2	1986	Now it seems that iron, and its transport and storage proteins transferrin, lactoferrin and ferritin are associated with the major sets of cells of the immune system, and may be able to modulate a variety of immunological functions.	Iron	18-22	transferrin	Homo sapiens	63-74
3096053-0	1986	Effects of transferrin genetic phenotypes on total iron-binding capacity.	Iron	51-55	transferrin	Homo sapiens	11-22
3945969-4	1986	Iron alone did not modify biliary parameters, but significantly increased the activity of ALA-S.	Iron	0-4	5'-aminolevulinate synthase 1	Rattus norvegicus	90-95
3945969-5	1986	Combined treatment with ethinyl estradiol plus iron partially corrected the reduction of BSIF and restored the activity of ALA-S and URO-D to control levels.	Iron	47-51	5'-aminolevulinate synthase 1	Rattus norvegicus	123-128
3942755-4	1986	The raised levels of caeruloplasmin and the lower iron saturation of transferrin contribute to these differences.	Iron	50-54	transferrin	Homo sapiens	69-80
3942755-7	1986	However, prolonged incubations with trypsin reduced the iron-binding capacity of transferrin and decreased the ferroxidase and antioxidant properties of caeruloplasmin.	Iron	56-60	transferrin	Homo sapiens	81-92
3545211-1	1986	The transferrin receptor binds the major serum iron-transport protein, transferrin, and mediates cellular iron uptake.	Iron	47-51	transferrin	Homo sapiens	4-15
3490132-1	1986	Macrolide antibiotics like Erythromycin and Tri-acetyl oleandomycin (TAO) are metabolized to nitrosoderivatives which cause inactivation of Cytochrome P-450 by forming stable complex with the Iron of the hemoporphyrin.	Iron	192-196	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-156
3826775-0	1986	[Capacity of iron fixation by the serum or immunochemical determination of transferrin?	Iron	13-17	transferrin	Homo sapiens	75-86
3545211-4	1986	The properties of monoclonal antibodies against the transferrin receptor that inhibit transferrin-mediated iron uptake are described.	Iron	107-111	transferrin	Homo sapiens	52-63
3545211-4	1986	The properties of monoclonal antibodies against the transferrin receptor that inhibit transferrin-mediated iron uptake are described.	Iron	107-111	transferrin	Homo sapiens	86-97
2463216-2	1986	The non-haem-iron proteins transferrin, conalbumin and ferritin release iron at an acid pH value, whereas the haem-iron proteins release iron more readily at an alkaline pH.	Iron	13-17	transferrin	Homo sapiens	27-38
3942693-0	1986	Fluorescence probe measurement of the pH of the transferrin microenvironment during iron uptake by rat bone marrow erythroid cells.	Iron	68-72	transferrin	Rattus norvegicus	48-59
3942693-1	1986	Fluorescence probe measurements of the transferrin micro-environment during iron uptake by rat erythroid cells revealed that part of the transferrin is taken up in an acidic environment.	Iron	60-64	transferrin	Rattus norvegicus	39-50
3942693-1	1986	Fluorescence probe measurements of the transferrin micro-environment during iron uptake by rat erythroid cells revealed that part of the transferrin is taken up in an acidic environment.	Iron	60-64	transferrin	Rattus norvegicus	137-148
3943149-0	1986	Role of transferrin in iron transport between maternal and fetal circulations of a perfused lobule of human placenta.	Iron	23-27	transferrin	Homo sapiens	8-19
3943149-6	1986	It is concluded that the initial stages of iron transfer to the fetus involve the internalization of maternal iron-saturated transferrin bound to membrane receptors by receptor-mediated endocytosis, which can be inhibited by the drug chloroquine.	Iron	43-47	transferrin	Homo sapiens	125-136
3943149-6	1986	It is concluded that the initial stages of iron transfer to the fetus involve the internalization of maternal iron-saturated transferrin bound to membrane receptors by receptor-mediated endocytosis, which can be inhibited by the drug chloroquine.	Iron	110-114	transferrin	Homo sapiens	125-136
3011533-1	1986	Serum transferrin (the iron binding protein) exerts its iron carrier function at the cell surface after binding to the appropriate receptor (TrR).	Iron	23-27	transferrin	Homo sapiens	6-17
3011533-1	1986	Serum transferrin (the iron binding protein) exerts its iron carrier function at the cell surface after binding to the appropriate receptor (TrR).	Iron	56-60	transferrin	Homo sapiens	6-17
3106157-1	1986	Transferrin is a major plasma protein that transports iron to proliferating cells throughout the body.	Iron	54-58	transferrin	Homo sapiens	0-11
3484636-0	1986	Iron uptake by MOLT 3 cells from transferrin/monoclonal antitransferrin antibody complexes.	Iron	0-4	transferrin	Homo sapiens	33-44
3484636-1	1986	The ability of seven monoclonal antibodies (MAbs) reactive with human transferrin (Tf) to inhibit iron uptake from Tf by cells of the human lymphoid line MOLT 3 was compared with the effect of these MAbs on Tf binding to MOLT 3 surface Tf receptors.	Iron	98-102	transferrin	Homo sapiens	70-81
3484636-1	1986	The ability of seven monoclonal antibodies (MAbs) reactive with human transferrin (Tf) to inhibit iron uptake from Tf by cells of the human lymphoid line MOLT 3 was compared with the effect of these MAbs on Tf binding to MOLT 3 surface Tf receptors.	Iron	98-102	transferrin	Homo sapiens	83-85
3484636-3	1986	Complexing Tf with MAbs HTF-04 or HTF-05 resulted in an increased association of Tf with the cells but iron uptake was diminished.	Iron	103-107	transferrin	Homo sapiens	11-13
3484636-4	1986	Following the intracellular kinetics of Tf/HTF-04 complex has shown that the whole complex is endocytosed and Tf iron is retained inside the cell, but Tf release from both the cell surface and the intracellular compartment is slower when compared to Tf alone.	Iron	113-117	transferrin	Homo sapiens	40-42
3484636-4	1986	Following the intracellular kinetics of Tf/HTF-04 complex has shown that the whole complex is endocytosed and Tf iron is retained inside the cell, but Tf release from both the cell surface and the intracellular compartment is slower when compared to Tf alone.	Iron	113-117	transferrin	Homo sapiens	110-112
3484636-4	1986	Following the intracellular kinetics of Tf/HTF-04 complex has shown that the whole complex is endocytosed and Tf iron is retained inside the cell, but Tf release from both the cell surface and the intracellular compartment is slower when compared to Tf alone.	Iron	113-117	transferrin	Homo sapiens	110-112
3484636-5	1986	Iron uptake inhibition was therefore attributed to lengthening of the Tf cell cycle after complexing of Tf with HTF-04 and it is suggested that the rate of cellular Tf turnover might, together with the number of functioning Tf receptors, determine the rate of iron uptake by cells.	Iron	0-4	transferrin	Homo sapiens	70-72
3484636-5	1986	Iron uptake inhibition was therefore attributed to lengthening of the Tf cell cycle after complexing of Tf with HTF-04 and it is suggested that the rate of cellular Tf turnover might, together with the number of functioning Tf receptors, determine the rate of iron uptake by cells.	Iron	0-4	transferrin	Homo sapiens	104-106
3484636-5	1986	Iron uptake inhibition was therefore attributed to lengthening of the Tf cell cycle after complexing of Tf with HTF-04 and it is suggested that the rate of cellular Tf turnover might, together with the number of functioning Tf receptors, determine the rate of iron uptake by cells.	Iron	0-4	transferrin	Homo sapiens	104-106
3484636-5	1986	Iron uptake inhibition was therefore attributed to lengthening of the Tf cell cycle after complexing of Tf with HTF-04 and it is suggested that the rate of cellular Tf turnover might, together with the number of functioning Tf receptors, determine the rate of iron uptake by cells.	Iron	0-4	transferrin	Homo sapiens	104-106
3484636-5	1986	Iron uptake inhibition was therefore attributed to lengthening of the Tf cell cycle after complexing of Tf with HTF-04 and it is suggested that the rate of cellular Tf turnover might, together with the number of functioning Tf receptors, determine the rate of iron uptake by cells.	Iron	260-264	transferrin	Homo sapiens	104-106
3484636-5	1986	Iron uptake inhibition was therefore attributed to lengthening of the Tf cell cycle after complexing of Tf with HTF-04 and it is suggested that the rate of cellular Tf turnover might, together with the number of functioning Tf receptors, determine the rate of iron uptake by cells.	Iron	260-264	transferrin	Homo sapiens	104-106
3484636-5	1986	Iron uptake inhibition was therefore attributed to lengthening of the Tf cell cycle after complexing of Tf with HTF-04 and it is suggested that the rate of cellular Tf turnover might, together with the number of functioning Tf receptors, determine the rate of iron uptake by cells.	Iron	260-264	transferrin	Homo sapiens	104-106
3514055-3	1986	Proteins such as transferrin and lactoferrin that are employed by vertebrate hosts for iron transport and acquisition can, to some extent, withhold the metal from the siderophores of invading bacteria and fungi.	Iron	87-91	transferrin	Homo sapiens	17-28
2463216-2	1986	The non-haem-iron proteins transferrin, conalbumin and ferritin release iron at an acid pH value, whereas the haem-iron proteins release iron more readily at an alkaline pH.	Iron	72-76	transferrin	Homo sapiens	27-38
2463216-2	1986	The non-haem-iron proteins transferrin, conalbumin and ferritin release iron at an acid pH value, whereas the haem-iron proteins release iron more readily at an alkaline pH.	Iron	72-76	transferrin	Homo sapiens	27-38
2463216-2	1986	The non-haem-iron proteins transferrin, conalbumin and ferritin release iron at an acid pH value, whereas the haem-iron proteins release iron more readily at an alkaline pH.	Iron	72-76	transferrin	Homo sapiens	27-38
3029212-5	1986	Conditions resulting in the most rapid release of iron from transferrin (low pH, high ADP) did not promote the greatest rates of lipid peroxidation, indicating that at neutral pH, rates of lipid peroxidation may be limited by the availability of iron.	Iron	50-54	transferrin	Homo sapiens	60-71
3002966-8	1986	These results strongly suggest that transferrin promotes lymphocyte proliferation solely as a result of its iron-donating properties, and that an additional role such as the provision of a proliferation-inducing membrane signalling event following interaction with the transferrin receptor seems unlikely.	Iron	108-112	transferrin	Homo sapiens	36-47
3007339-3	1986	This indicates that the function of the transferrin receptor is directly to provide a component essential for DNA synthesis itself (probably iron) rather than to act as the receptor for a general signal required to initiate entry into S-phase.	Iron	141-145	transferrin	Homo sapiens	40-51
3792614-1	1986	Nontransferrin-bound iron (NTBI) was separated from transferrin bound iron (TBI) by DEAE-Sephadex-CDS filtration.	Iron	21-25	transferrin	Homo sapiens	3-14
3029212-1	1986	The potential for iron bound to transferrin to be released and promote the peroxidation of phospholipid liposomes was investigated using ADP as a low molecular weight chelator and superoxide generated by the xanthine/xanthine oxidase system as the reducing agent.	Iron	18-22	transferrin	Homo sapiens	32-43
3029212-2	1986	Lipid peroxidation in this system was dependent upon transferrin as the source of iron; increasing the transferrin concentration resulted in increased rates of lipid peroxidation.	Iron	82-86	transferrin	Homo sapiens	53-64
3029212-2	1986	Lipid peroxidation in this system was dependent upon transferrin as the source of iron; increasing the transferrin concentration resulted in increased rates of lipid peroxidation.	Iron	82-86	transferrin	Homo sapiens	103-114
3002966-0	1986	Evidence that transferrin may function exclusively as an iron donor in promoting lymphocyte proliferation.	Iron	57-61	transferrin	Homo sapiens	14-25
3002966-3	1986	In serum-free medium, proliferation was greater in the presence of 30% iron-saturated transferrin than when the protein was saturated only to 10%.	Iron	71-75	transferrin	Homo sapiens	86-97
3002966-5	1986	Lymphocytes took up iron preferentially when transferrin containing both iron and manganese was present in the culture medium.	Iron	20-24	transferrin	Homo sapiens	45-56
3002966-5	1986	Lymphocytes took up iron preferentially when transferrin containing both iron and manganese was present in the culture medium.	Iron	73-77	transferrin	Homo sapiens	45-56
3002966-6	1986	The degree of proliferation in serum-free medium in the presence of a variant of human transferrin with abnormal iron-binding and receptor-binding properties was almost identical to that when normal human transferrin was used.	Iron	113-117	transferrin	Homo sapiens	87-98
4084303-1	1985	Short-term alterations in the amount of iron in the diets of rats caused substantial differences in the distribution of a test dose of radioiron between mucosal transferrin and mucosal ferritin, and also caused a change in the relative amounts of these two proteins in mucosal tissue without resulting in any detectable change in liver iron stores.	Iron	40-44	transferrin	Rattus norvegicus	161-172
3738220-2	1986	In the plasma as well as in the bile there is a decrease of iron and an increase of transferrin due to iron depletion, whereas the albumin level remains constant.	Iron	103-107	transferrin	Rattus norvegicus	84-95
3785148-1	1986	Treatment of K562 cells with desferrioxamine, a permeable iron chelator, led to an increase in the number of transferrin receptors.	Iron	58-62	transferrin	Homo sapiens	109-120
3785148-2	1986	Increasing intracellular iron levels by treatment of cells with either human diferric transferrin or hemin lowered the level of the transferrin receptors.	Iron	25-29	transferrin	Homo sapiens	86-97
3785148-2	1986	Increasing intracellular iron levels by treatment of cells with either human diferric transferrin or hemin lowered the level of the transferrin receptors.	Iron	25-29	transferrin	Homo sapiens	132-143
3961228-0	1986	[Quantitative relation between transferrin and total iron fixation capacity in patients carrying heterozygous A2 and F thalassemia].	Iron	53-57	transferrin	Homo sapiens	31-42
2419931-14	1985	radical is a major damaging agent in the inflamed rheumatoid joint and that its formation is facilitated by the release of iron from transferrin, which can be achieved at the low pH present in the micro-environment created by adherent activated phagocytic cells.	Iron	123-127	transferrin	Homo sapiens	133-144
4084303-1	1985	Short-term alterations in the amount of iron in the diets of rats caused substantial differences in the distribution of a test dose of radioiron between mucosal transferrin and mucosal ferritin, and also caused a change in the relative amounts of these two proteins in mucosal tissue without resulting in any detectable change in liver iron stores.	Iron	140-144	transferrin	Rattus norvegicus	161-172
4066687-4	1985	Some other low molecular weight, saturated iron chelators such as glycyl-histidyl-lysine acetate, nitrilotriacetic acid, ascorbate, citrate, and unchelated ferrous sulfate could not support as high a degree of proliferation as FePIH or transferrin.	Iron	43-47	transferrin	Homo sapiens	236-247
3000447-1	1985	The uptake of iron (III) mediated by lactotransferrin to human biopsies from upper intestine has suggested the presence of specific receptors for human lactotransferrin at the brush border (Cox, T., Mazurier, J., Spik, G., Montreuil, J. and Peters, T.J. (1979) Biochim.	Iron	14-18	lactotransferrin	Homo sapiens	37-53
3000447-1	1985	The uptake of iron (III) mediated by lactotransferrin to human biopsies from upper intestine has suggested the presence of specific receptors for human lactotransferrin at the brush border (Cox, T., Mazurier, J., Spik, G., Montreuil, J. and Peters, T.J. (1979) Biochim.	Iron	14-18	lactotransferrin	Homo sapiens	152-168
4091824-3	1985	Iron entering the cells on transferrin was subsequently found in a number of intracellular components: transferrin, haem, ferritin and a residual fraction.	Iron	0-4	transferrin	Rattus norvegicus	27-38
4066687-6	1985	The octanol/saline partition coefficients of radioactive iron in solution with transferrin, nitrilotriacetic acid, or chloride were all less than 0.06.	Iron	57-61	transferrin	Homo sapiens	79-90
4091824-3	1985	Iron entering the cells on transferrin was subsequently found in a number of intracellular components: transferrin, haem, ferritin and a residual fraction.	Iron	0-4	transferrin	Rattus norvegicus	103-114
4066687-10	1985	Transferrin is not lipophilic but it delivers iron by receptor-mediated endocytosis.	Iron	46-50	transferrin	Homo sapiens	0-11
4091824-4	1985	After 2 h incubation with 59Fe-transferrin almost 70% of the iron was in ferritin, and this proportion increased to 80% during a "chase" experiment.	Iron	61-65	transferrin	Rattus norvegicus	31-42
2867745-1	1985	Mixed-function oxidation of Escherichia coli glutamine synthetase by ascorbate, oxygen, and iron has previously been shown to cause inactivation of the enzyme and enhanced susceptibility to proteolytic attack by a variety of proteases.	Iron	92-96	glutamate-ammonia ligase	Homo sapiens	45-65
2999105-8	1985	The isolated iron-sulfur protein catalyzes reduction of cytochrome c by ubiquinol, which is insensitive to antimycin, at a rate of 0.03 mumol of cytochrome c reduced/min/nmol of protein, while the purified cytochrome c1 has no such catalytic activity.	Iron	13-17	cytochrome c, somatic	Homo sapiens	56-68
2999105-8	1985	The isolated iron-sulfur protein catalyzes reduction of cytochrome c by ubiquinol, which is insensitive to antimycin, at a rate of 0.03 mumol of cytochrome c reduced/min/nmol of protein, while the purified cytochrome c1 has no such catalytic activity.	Iron	13-17	cytochrome c, somatic	Homo sapiens	145-157
2999105-9	1985	When cytochrome c1 and the iron-sulfur protein form a complex, the rate of cytochrome c reduction increases to 0.12 mumol/min/nmol of the iron-sulfur protein.	Iron	27-31	cytochrome c, somatic	Homo sapiens	5-17
2999105-10	1985	In this reaction, cytochrome c1 mediates antimycin-insensitive electron transfer from the iron-sulfur protein to cytochrome c, thereby constituting a pathway of electrons: ubiquinol----iron-sulfur protein----cytochrome c1----cytochrome c.	Iron	90-94	cytochrome c, somatic	Homo sapiens	18-30
2999105-10	1985	In this reaction, cytochrome c1 mediates antimycin-insensitive electron transfer from the iron-sulfur protein to cytochrome c, thereby constituting a pathway of electrons: ubiquinol----iron-sulfur protein----cytochrome c1----cytochrome c.	Iron	90-94	cytochrome c, somatic	Homo sapiens	113-125
4072957-5	1985	Iron treatment for a 3-mo period resulted in substantive increases in mean Hgb, Hct, and transferrin saturation among the iron-deficient anemic children.	Iron	0-4	transferrin	Homo sapiens	89-100
2999796-3	1985	An equal amount of unconjugated neuraminidase had no effect, and desialylation of class II antigen components was blocked when access of transferrin-neuraminidase conjugates to the B-LCL transferrin receptors was competitively inhibited by the addition of excess iron-saturated transferrin.	Iron	263-267	transferrin	Homo sapiens	137-148
4063529-0	1985	Quantitation of apo-, mono-, and diferric transferrin by polyacrylamide gradient gel electrophoresis in patients with disorders of iron metabolism.	Iron	131-135	transferrin	Homo sapiens	42-53
4063529-2	1985	Purified transferrin saturated to different extents (3% to 98%) with iron showed proportions of the three forms as predicted from an approximately random distribution of iron between the two metal-binding sites.	Iron	69-73	transferrin	Homo sapiens	9-20
4063529-2	1985	Purified transferrin saturated to different extents (3% to 98%) with iron showed proportions of the three forms as predicted from an approximately random distribution of iron between the two metal-binding sites.	Iron	170-174	transferrin	Homo sapiens	9-20
4063529-4	1985	In contrast, 22 of 43 patients with diseases associated with abnormalities in iron or transferrin metabolism had a disproportionate increase in monoferric transferrin.	Iron	78-82	transferrin	Homo sapiens	155-166
4063529-7	1985	The finding of abnormal distributions of iron on transferrin suggests that gradient gel analysis may be a useful tool for studying the physiologic mechanisms controlling iron utilization.	Iron	41-45	transferrin	Homo sapiens	49-60
4063529-7	1985	The finding of abnormal distributions of iron on transferrin suggests that gradient gel analysis may be a useful tool for studying the physiologic mechanisms controlling iron utilization.	Iron	170-174	transferrin	Homo sapiens	49-60
2999796-3	1985	An equal amount of unconjugated neuraminidase had no effect, and desialylation of class II antigen components was blocked when access of transferrin-neuraminidase conjugates to the B-LCL transferrin receptors was competitively inhibited by the addition of excess iron-saturated transferrin.	Iron	263-267	transferrin	Homo sapiens	187-198
2999796-3	1985	An equal amount of unconjugated neuraminidase had no effect, and desialylation of class II antigen components was blocked when access of transferrin-neuraminidase conjugates to the B-LCL transferrin receptors was competitively inhibited by the addition of excess iron-saturated transferrin.	Iron	263-267	transferrin	Homo sapiens	187-198
4055797-3	1985	At low concentrations of ionophores (0.25-0.5 microM), the disruption of the compartment in which iron is released affected minimally the release of iron from transferrin but effectively inhibited iron uptake.	Iron	149-153	transferrin	Homo sapiens	159-170
3877057-10	1985	The ability of rough microsomal transferrin to bind and deliver iron through interaction with transferrin receptors on reticulocytes suggests that considerable tertiary structure is present.	Iron	64-68	transferrin	Rattus norvegicus	32-43
3877057-10	1985	The ability of rough microsomal transferrin to bind and deliver iron through interaction with transferrin receptors on reticulocytes suggests that considerable tertiary structure is present.	Iron	64-68	transferrin	Rattus norvegicus	94-105
4055798-0	1985	Acquisition of iron from transferrin regulates reticulocyte heme synthesis.	Iron	15-19	transferrin	Homo sapiens	25-36
4055797-3	1985	At low concentrations of ionophores (0.25-0.5 microM), the disruption of the compartment in which iron is released affected minimally the release of iron from transferrin but effectively inhibited iron uptake.	Iron	149-153	transferrin	Homo sapiens	159-170
4055798-1	1985	Fe-salicylaldehyde isonicotinoylhydrazone (SIH), which can donate iron to reticulocytes without transferrin as a mediator, has been utilized to test the hypothesis that the rate of iron uptake from transferrin limits the rate of heme synthesis in erythroid cells.	Iron	181-185	transferrin	Homo sapiens	198-209
4055798-5	1985	Taken together, these results suggest the hypothesis that some step(s) in the pathway of iron from extracellular transferrin to intracellular protoporphyrin limits the overall rate of heme synthesis in reticulocytes.	Iron	89-93	transferrin	Homo sapiens	113-124
4055797-4	1985	Iron released from transferrin was extruded from the cell synchronously with but not bound to transferrin.	Iron	0-4	transferrin	Homo sapiens	19-30
4055797-5	1985	The compartment disrupted by the ionophores, and in which iron is released from transferrin, is apparently contiguous to the extracellular medium.	Iron	58-62	transferrin	Homo sapiens	80-91
4055797-7	1985	The above data fit a model of iron uptake in which iron is released from transferrin in an acidic compartment in immediate contiguity with the cell plasma membrane.	Iron	30-34	transferrin	Homo sapiens	73-84
4055797-7	1985	The above data fit a model of iron uptake in which iron is released from transferrin in an acidic compartment in immediate contiguity with the cell plasma membrane.	Iron	51-55	transferrin	Homo sapiens	73-84
4074838-0	1985	The effect of iron binding on the conformation of transferrin.	Iron	14-18	transferrin	Homo sapiens	50-61
4063390-5	1985	Previously we had shown that iron uptake into cells and onto cellular transferrin was virtually the same throughout the small intestine, irrespective of the iron-absorbing capacity of the region.	Iron	29-33	transferrin	Rattus norvegicus	70-81
4063390-6	1985	The results of this study therefore suggest that iron absorption depends on an intact cytoskeletal system and that ferritin in the iron-absorbing cell is able to load from the pool of iron committed to transcellular movement onto plasma transferrin.	Iron	131-135	transferrin	Rattus norvegicus	237-248
4063390-6	1985	The results of this study therefore suggest that iron absorption depends on an intact cytoskeletal system and that ferritin in the iron-absorbing cell is able to load from the pool of iron committed to transcellular movement onto plasma transferrin.	Iron	131-135	transferrin	Rattus norvegicus	237-248
3002171-1	1985	Transport of iron across the cell membrane is mediated by the iron-binding serum protein, transferrin, and its cell-surface receptor.	Iron	13-17	transferrin	Homo sapiens	90-101
3002171-1	1985	Transport of iron across the cell membrane is mediated by the iron-binding serum protein, transferrin, and its cell-surface receptor.	Iron	62-66	transferrin	Homo sapiens	90-101
3002171-2	1985	Transferrin receptor is required for cell proliferation and may play a functional role in the pathogenesis of iron-storage disorders and some neoplasias.	Iron	110-114	transferrin	Homo sapiens	0-11
4061393-7	1985	Mean hemoglobin in patients with iron overload (transferrin saturation, TS greater than 50%) was lower than in those without (P less than 0.005).	Iron	33-37	transferrin	Homo sapiens	48-59
4074838-4	1985	An unusual feature of the stepwise structural changes of transferrin upon iron saturation is that binding of the first ferric ion is responsible for more than half of the whole change in Rq, whereas Rg alters significantly only after the binding of the second ferric ion.	Iron	74-78	transferrin	Homo sapiens	57-68
2996611-1	1985	Diferric transferrin as iron donor and the effect of pyrophosphate.	Iron	24-28	transferrin	Homo sapiens	9-20
3902782-3	1985	Other more simple supplementations of our basal medium MEM.S/F12 (transferrin + insulin, transferrin + selenium, ferrous iron + selenium) also give good cell growth responses.	Iron	113-125	coagulation factor XII	Cricetulus griseus	61-64
4056038-0	1985	Efficient clearance of non-transferrin-bound iron by rat liver.	Iron	45-49	transferrin	Rattus norvegicus	27-38
4056038-10	1985	These findings suggest that high levels of non-transferrin-bound iron in plasma may be an important cause of hepatic iron loading in iron overload states.	Iron	65-69	transferrin	Rattus norvegicus	47-58
4056038-10	1985	These findings suggest that high levels of non-transferrin-bound iron in plasma may be an important cause of hepatic iron loading in iron overload states.	Iron	117-121	transferrin	Rattus norvegicus	47-58
4056038-10	1985	These findings suggest that high levels of non-transferrin-bound iron in plasma may be an important cause of hepatic iron loading in iron overload states.	Iron	117-121	transferrin	Rattus norvegicus	47-58
4081644-0	1985	Does plasma transferrin regulate iron absorption?	Iron	33-37	transferrin	Homo sapiens	12-23
4081644-1	1985	It has been suggested that transferrin that has recently donated its iron to receptor sites is "activated" to take up iron more avidly from donor tissues.	Iron	69-73	transferrin	Homo sapiens	27-38
4081644-6	1985	Using this in vitro system no supporting evidence could be found for the hypothesis that diferric transferrin which has just donated its iron is able to bind available iron more avidly than native apotransferrin.	Iron	137-141	transferrin	Homo sapiens	98-109
4081644-6	1985	Using this in vitro system no supporting evidence could be found for the hypothesis that diferric transferrin which has just donated its iron is able to bind available iron more avidly than native apotransferrin.	Iron	168-172	transferrin	Homo sapiens	98-109
4029396-4	1985	Both chelators are able to remove iron completely from diferric transferrin without additional mediators or reducing agents.	Iron	34-38	transferrin	Homo sapiens	64-75
3840094-2	1985	Results indicate that the rate limiting enzymes delta-aminolevulinic acid synthase (ALAS) and heme oxygenase were significantly elevated in the iron-overloaded hepatic and bone marrow cells and near normal levels in cells from iron-deficient rats.	Iron	144-148	5'-aminolevulinate synthase 1	Rattus norvegicus	48-82
3840094-2	1985	Results indicate that the rate limiting enzymes delta-aminolevulinic acid synthase (ALAS) and heme oxygenase were significantly elevated in the iron-overloaded hepatic and bone marrow cells and near normal levels in cells from iron-deficient rats.	Iron	144-148	5'-aminolevulinate synthase 1	Rattus norvegicus	84-88
3840094-2	1985	Results indicate that the rate limiting enzymes delta-aminolevulinic acid synthase (ALAS) and heme oxygenase were significantly elevated in the iron-overloaded hepatic and bone marrow cells and near normal levels in cells from iron-deficient rats.	Iron	227-231	5'-aminolevulinate synthase 1	Rattus norvegicus	48-82
3840094-2	1985	Results indicate that the rate limiting enzymes delta-aminolevulinic acid synthase (ALAS) and heme oxygenase were significantly elevated in the iron-overloaded hepatic and bone marrow cells and near normal levels in cells from iron-deficient rats.	Iron	227-231	5'-aminolevulinate synthase 1	Rattus norvegicus	84-88
3840094-3	1985	Conversely, delta-aminolevulinic acid dehydrase (ALAD) was depressed in iron-overloaded cells and elevated in iron-deficient cells.	Iron	72-76	aminolevulinate dehydratase	Rattus norvegicus	12-47
3840094-3	1985	Conversely, delta-aminolevulinic acid dehydrase (ALAD) was depressed in iron-overloaded cells and elevated in iron-deficient cells.	Iron	110-114	aminolevulinate dehydratase	Rattus norvegicus	12-47
4044661-1	1985	The mechanism of iron uptake from transferrin by the rat placenta in culture has been studied.	Iron	17-21	transferrin	Rattus norvegicus	34-45
4044661-2	1985	Transferrin endocytosis preceded iron accumulation by the cells.	Iron	33-37	transferrin	Rattus norvegicus	0-11
4044661-4	1985	Transferrin endocytosis was less susceptible to the effects of metabolic inhibitors such as sodium fluoroacetate, potassium cyanide, 2,4, dinitrophenol or carbonylcyanide M-chlorophenyl hydrazone (CCCP) than was iron uptake.	Iron	212-216	transferrin	Rattus norvegicus	0-11
4044661-6	1985	These results suggest that, following internalisation, the vesicles containing the transferrin and iron became acidified, and that this acidification was a necessary prerequisite for the accumulation of iron by the cell.	Iron	203-207	transferrin	Rattus norvegicus	83-94
4044661-8	1985	The importance of the permeability properties of the vesicle membrane in the iron uptake process was investigated by incubating the cells with labelled transferrin and iron in the presence of different cation and anion ionophores.	Iron	77-81	transferrin	Rattus norvegicus	152-163
3928965-1	1985	Phagocytosis of carbonyl iron beads by rat alveolar macrophages induces the production of cyclooxygenase and lipoxygenase metabolites of arachidonic acid (AA).	Iron	25-29	LOC543232	Triticum aestivum	109-121
3909071-0	1985	[Rapid analysis of transferrin-iron complexes by isoelectric focusing and radioactive densitometry on gel].	Iron	31-35	transferrin	Homo sapiens	19-30
3909071-1	1985	The analysis of the molecular forms of transferrin-iron complexes with 59Fe, was carried out using an isoelectric focusing method on commercially available polyacrylamide plates (PAG plates pH = 4-6,5, LKB).	Iron	51-55	transferrin	Homo sapiens	39-50
2991275-8	1985	Catalase prevented the killing by menadione of deferoxamine-pretreated hepatocytes given either ferric or ferrous iron.	Iron	106-118	catalase	Homo sapiens	0-8
4019471-1	1985	Marrow cells induced toward erythroid differentiation by treatment with erythropoietin respond by increasing the rates of iron uptake and hemoglobin synthesis.	Iron	122-126	erythropoietin	Homo sapiens	72-86
2415022-0	1985	A specific iron stain for iron-binding proteins in polyacrylamide gels: application to transferrin and lactoferrin.	Iron	11-15	transferrin	Homo sapiens	87-98
2415022-1	1985	A new method for specifically staining the iron atoms present in transferrin and lactoferrin after polyacrylamide gel electrophoresis and isoelectric focusing is described.	Iron	43-47	transferrin	Homo sapiens	65-76
3930665-12	1985	Brain utilization of Tf, meeting the brain iron requirement, seems likely.	Iron	43-47	transferrin	Homo sapiens	21-23
2991909-1	1985	Addition of hemin to reticulocytes inhibits incorporation of iron from transferrin [Ponka, P. & Neuwirt, J.	Iron	61-65	transferrin	Homo sapiens	71-82
2991909-8	1985	Hemin reduced the initial influx of transferrin, thereby diminishing incorporation of iron.	Iron	86-90	transferrin	Homo sapiens	36-47
2992467-2	1985	Rhodanese, also a mitochondrial enzyme, is thought to be required for synthesis of iron-sulfur centers, such as those contained in adrenodoxin.	Iron	83-87	thiosulfate sulfurtransferase	Bos taurus	0-9
3862428-0	1985	Release of iron from the two iron-binding sites of transferrin by cultured human cells: modulation by methylamine.	Iron	11-15	transferrin	Homo sapiens	51-62
3862428-0	1985	Release of iron from the two iron-binding sites of transferrin by cultured human cells: modulation by methylamine.	Iron	29-33	transferrin	Homo sapiens	51-62
3862428-1	1985	We have investigated the effect of increasing concentrations of methylamine (5, 10, and 25 mM) on the removal of iron from the two iron-binding sites of transferrin during endocytosis by human erythroleukemia (K562) cells.	Iron	113-117	transferrin	Homo sapiens	153-164
3862428-1	1985	We have investigated the effect of increasing concentrations of methylamine (5, 10, and 25 mM) on the removal of iron from the two iron-binding sites of transferrin during endocytosis by human erythroleukemia (K562) cells.	Iron	131-135	transferrin	Homo sapiens	153-164
3862428-4	1985	Although transferrin exocytosed from control cells had been depleted of 80% of its iron and contained 65-70% apotransferrin, iron-bearing species were also released (15% C-terminal monoferric; 10% N-terminal; 10% diferric).	Iron	83-87	transferrin	Homo sapiens	9-20
3862428-7	1985	Small amounts of the iron-depleted species, especially apotransferrin, appeared before diferric transferrin, suggesting that these were preferentially released from the cells.	Iron	21-25	transferrin	Homo sapiens	58-69
3862428-9	1985	The N-terminal site of transferrin loses its iron at a higher pH than the C-terminal site, and so by progressively perturbing the pH of the endocytic vesicle we have increased the difference between the two sites observed with control cells.	Iron	45-49	transferrin	Homo sapiens	23-34
2994783-4	1985	Most of this variation, estimated at 72% by regression analysis, was due to a direct relationship between transferrin saturation and plasma iron turnover.	Iron	140-144	transferrin	Homo sapiens	106-117
2994783-5	1985	This effect was attributed to a competitive advantage of diferric over monoferric transferrin in delivering iron to tissues.	Iron	108-112	transferrin	Homo sapiens	82-93
2994783-9	1985	The amount of iron-bearing transferrin leaving the plasma to bind to tissue receptors for 53 subjects with a transferrin saturation between 17% and 57% was 71 +/- 13; for 25 subjects with a saturation from 67% to 100%, 72 +/- 12; and for five subjects with early idiopathic hemochromatosis, 82 +/- 11 mumol/L whole blood/d.	Iron	14-18	transferrin	Homo sapiens	27-38
2994783-9	1985	The amount of iron-bearing transferrin leaving the plasma to bind to tissue receptors for 53 subjects with a transferrin saturation between 17% and 57% was 71 +/- 13; for 25 subjects with a saturation from 67% to 100%, 72 +/- 12; and for five subjects with early idiopathic hemochromatosis, 82 +/- 11 mumol/L whole blood/d.	Iron	14-18	transferrin	Homo sapiens	109-120
2994783-11	1985	These studies indicate that while the number of iron atoms delivered to the tissues increases with increasing plasma iron and transferrin saturation, the number of iron-bearing transferrin molecules that leave the plasma per unit time to bind to tissue receptors is relatively constant and within the limits studied, independent of transferrin saturation.	Iron	48-52	transferrin	Homo sapiens	126-137
4029396-0	1985	Site specificity of iron removal from transferrin by alpha-ketohydroxypyridine chelators.	Iron	20-24	transferrin	Homo sapiens	38-49
4029396-1	1985	The site specificity of the removal of iron from diferric human transferrin, at pH 7.4, by two alpha-ketohydroxypyridine chelators, 1,2-dimethyl-3-hydroxypyrid-4-one (L1) and mimosine, has been investigated using urea-polyacrylamide gel electrophoresis.	Iron	39-43	transferrin	Homo sapiens	64-75
4029396-3	1985	The removal of iron has also been followed spectrophotometrically and by monitoring the loss of 59Fe from [59Fe]transferrin.	Iron	15-19	transferrin	Homo sapiens	112-123
4041811-0	1985	Iron concentration reduced in ventral pallidum, globus pallidus, and substantia nigra by GABA-transaminase inhibitor, gamma-vinyl GABA.	Iron	0-4	4-aminobutyrate aminotransferase	Rattus norvegicus	89-106
2993149-2	1985	A third component functionally linked to transferrin and its receptor is the intracellular iron-storage protein, ferritin, which ensures against toxic levels of free ferrous iron, which might otherwise cause peroxidative damage to cell membranes and other cell structures (1).	Iron	91-95	transferrin	Homo sapiens	41-52
2995450-10	1985	Furthermore, when measles-infected HeLa cells were grown for 6 d in medium supplemented with iron-saturated human transferrin they underwent a 50% reduction in receptor expression but no change in NK susceptibility.	Iron	93-97	transferrin	Homo sapiens	114-125
4020242-2	1985	Radioactive iron uptake per 2 X 10(6) cells/24 hr was 3.8% for 59Fe-transferrin, 15.8% for 59Fe-ferric ammonium citrate (FeAC) at 20 micrograms Fe/ml in 20% serum, and 37.1% for 59FeAC at 20 micrograms Fe/ml in serum-free medium.	Iron	12-16	transferrin	Rattus norvegicus	68-79
4020242-2	1985	Radioactive iron uptake per 2 X 10(6) cells/24 hr was 3.8% for 59Fe-transferrin, 15.8% for 59Fe-ferric ammonium citrate (FeAC) at 20 micrograms Fe/ml in 20% serum, and 37.1% for 59FeAC at 20 micrograms Fe/ml in serum-free medium.	Iron	65-67	transferrin	Rattus norvegicus	68-79
2989285-6	1985	Our results strongly suggest that chloride binds to the sixth coordination position of the chlorin iron in myeloperoxidase by replacing the water which is the sixth ligand in the resting state.	Iron	99-103	myeloperoxidase	Homo sapiens	107-122
2988630-1	1985	A single-sited iron-binding fragment of human transferrin has been obtained by thermolysin cleavage of the protein, selectively loaded with iron in the C-terminal binding site, in a urea-containing buffer.	Iron	15-19	transferrin	Homo sapiens	46-57
2988630-1	1985	A single-sited iron-binding fragment of human transferrin has been obtained by thermolysin cleavage of the protein, selectively loaded with iron in the C-terminal binding site, in a urea-containing buffer.	Iron	140-144	transferrin	Homo sapiens	46-57
2990522-0	1985	The iron-chelating agent picolinic acid enhances transferrin receptors expression in human erythroleukaemic cell lines.	Iron	4-8	transferrin	Homo sapiens	49-60
2990522-6	1985	Other iron-chelating compounds, capable of reducing the level of intracellular iron, also elicited a marked enhancement of the transferrin-binding capacity of the cells.	Iron	6-10	transferrin	Homo sapiens	127-138
2990522-6	1985	Other iron-chelating compounds, capable of reducing the level of intracellular iron, also elicited a marked enhancement of the transferrin-binding capacity of the cells.	Iron	79-83	transferrin	Homo sapiens	127-138
2990522-7	1985	However, the addition of iron, as ferric ammonium citrate, in the culture medium elicited a marked increase in the level of ferritin and a strong decrease in the transferrin-binding capacity of the cells.	Iron	25-29	transferrin	Homo sapiens	162-173
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	147-151	transferrin	Homo sapiens	98-109
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	147-151	transferrin	Homo sapiens	180-191
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	147-151	transferrin	Homo sapiens	180-191
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	246-250	transferrin	Homo sapiens	98-109
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	246-250	transferrin	Homo sapiens	180-191
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	246-250	transferrin	Homo sapiens	180-191
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	246-250	transferrin	Homo sapiens	98-109
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	246-250	transferrin	Homo sapiens	180-191
2990522-8	1985	On the basis of these data we propose that a feed-back mechanism is involved in the regulation of transferrin receptors: when the cells accumulate iron they decrease the number of transferrin receptors in order to prevent further accumulation of iron; when no or low iron is available to the cells, the number of transferrin receptors markedly increases as a compensatory mechanism.	Iron	246-250	transferrin	Homo sapiens	180-191
3877043-3	1985	These isozymes actively demethylate and oxidize these macrolides into nitrosoalkanes which form stable, inactive complexes with the iron of cytochrome P-450.	Iron	132-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	140-156
2989832-0	1985	Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution.	Iron	82-86	transferrin	Rattus norvegicus	0-11
2989832-5	1985	Iron-rich brain areas generally receive neuronal projections from areas with abundant transferrin receptors, suggesting that iron may be transported neuronally.	Iron	0-4	transferrin	Rattus norvegicus	86-97
2989832-5	1985	Iron-rich brain areas generally receive neuronal projections from areas with abundant transferrin receptors, suggesting that iron may be transported neuronally.	Iron	125-129	transferrin	Rattus norvegicus	86-97
3995083-7	1985	Saturation of transferrin with Fe3+ (1.6 micrograms Fe/mg) prevented the binding of 54Mn indicating that Mn probably binds to Fe-binding sites on the protein.	Iron	31-33	transferrin	Homo sapiens	14-25
2987233-1	1985	Iron delivery to K562 cells is enhanced by desferrioxamine through induction of transferrin receptors.	Iron	0-4	transferrin	Homo sapiens	80-91
2987233-3	1985	In control cells, up to 85% of the iron taken up from iron-transferrin was incorporated into ferritin, 7% into heme, and the remainder into compartments not yet identified.	Iron	35-39	transferrin	Homo sapiens	59-70
3996408-4	1985	The iron chelator desferrioxamine at a concentration of 10 microM or higher brought about an irreversible loss of enzyme activity of a partially purified preparation containing an excess of catalase, whereas this same chelator at a lower concentration afforded considerable protection of the enzyme"s activity during the final purification stage despite the quasi-total absence of catalase and the presence of an excess of ferrous iron.	Iron	4-8	catalase	Rattus norvegicus	190-198
3996408-4	1985	The iron chelator desferrioxamine at a concentration of 10 microM or higher brought about an irreversible loss of enzyme activity of a partially purified preparation containing an excess of catalase, whereas this same chelator at a lower concentration afforded considerable protection of the enzyme"s activity during the final purification stage despite the quasi-total absence of catalase and the presence of an excess of ferrous iron.	Iron	4-8	catalase	Rattus norvegicus	381-389
3991607-0	1985	Molecular advantage of diferric transferrin in delivering iron to reticulocytes: a comparative study.	Iron	58-62	transferrin	Homo sapiens	32-43
3991607-1	1985	The delivery of transferrin iron from four animal species and man to homologous reticulocytes was measured at different transferrin saturations.	Iron	28-32	transferrin	Homo sapiens	16-27
3991607-2	1985	Total iron uptake in the in vitro reticulocyte incubation model employed followed a hyperbolic curve, increasing as the transferrin saturation increased but at a progressively slower rate.	Iron	6-10	transferrin	Homo sapiens	120-131
3991607-4	1985	The majority of iron was delivered from diferric transferrin when transferrin saturations exceeded 13-19% depending on the species.	Iron	16-20	transferrin	Homo sapiens	49-60
3991607-4	1985	The majority of iron was delivered from diferric transferrin when transferrin saturations exceeded 13-19% depending on the species.	Iron	16-20	transferrin	Homo sapiens	66-77
3991607-5	1985	Thus a general similarity exists in the transferrin-iron interactions in these mammalian species.	Iron	52-56	transferrin	Homo sapiens	40-51
3991607-6	1985	Formuli have been provided whereby the iron utilization curve may be calculated when uptake has been determined at any one transferrin saturation.	Iron	39-43	transferrin	Homo sapiens	123-134
2985447-0	1985	Resonance Raman evidence of chloride binding to the heme iron in myeloperoxidase.	Iron	57-61	myeloperoxidase	Homo sapiens	65-80
2988598-3	1985	Iron-binding sites were localized by acid ferrocyanide (AF) staining after saturation of tissue specimens with iron, accomplished with iron nitrilotriacetate (FeNTA), a known transferrin iron donor.	Iron	0-4	transferrin	Homo sapiens	175-186
2580749-5	1985	The rate and extent of iron binding were identical for both glucosylated and nonglucosylated transferrin.	Iron	23-27	transferrin	Homo sapiens	93-104
3921391-10	1985	However, when iron-saturated bovine transferrin is digested with trypsin, the peptide fragments produced resemble the FBS factor in activity, size, and reaction with antibovine serum transferrin.	Iron	14-18	serotransferrin	Bos taurus	36-47
3921391-10	1985	However, when iron-saturated bovine transferrin is digested with trypsin, the peptide fragments produced resemble the FBS factor in activity, size, and reaction with antibovine serum transferrin.	Iron	14-18	serotransferrin	Bos taurus	183-194
3987629-8	1985	These results indicate that the antibodies inhibit side-chain cleavage by binding to a region close to the iron-sulfur protein-binding site, thereby preventing transfer of reducing electrons to the cytochrome P-450.	Iron	107-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	198-214
3989357-0	1985	Guinea pig and human red cell hemolysates release iron from transferrin.	Iron	50-54	transferrin	Homo sapiens	60-71
3989357-1	1985	Despite a binding constant of 10(22) L/mol-1, iron is released from transferrin in the reticulocyte.	Iron	46-50	transferrin	Homo sapiens	68-79
3989357-3	1985	It has been suggested that iron is released from transferrin in endocytic vesicles that have been acidified.	Iron	27-31	transferrin	Homo sapiens	49-60
3989357-4	1985	But the carboxy-terminal iron in transferrin is acid stable at the pH apparently achieved in the endocytic vesicle, and is, nevertheless, released.	Iron	25-29	transferrin	Homo sapiens	33-44
3989357-5	1985	We found that red cell hemolysates, at neutral pH, will release iron from transferrin.	Iron	64-68	transferrin	Homo sapiens	74-85
4009165-4	1985	It is suggested that the inhibitory activity of ceruloplasmin mainly depends on the ferroxidase activity and that of transferrin is probably due to iron binding property.	Iron	148-152	transferrin	Homo sapiens	117-128
3875933-1	1985	Pirenzepine interacts with the haem iron of cytochrome P-450 from rat-and pig-liver microsomes, to give absorption spectra with max.	Iron	36-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
2985429-1	1985	The effects of either iron salts or iron chelators on the biosynthesis of transferrin receptors in human erythroleukemic lines was investigated.	Iron	22-26	transferrin	Homo sapiens	74-85
2985429-2	1985	Addition of these compounds induced a rapid and marked decrease (iron salts) or increase (iron chelators) in the level of transferrin receptors synthesis.	Iron	65-69	transferrin	Homo sapiens	122-133
2985429-2	1985	Addition of these compounds induced a rapid and marked decrease (iron salts) or increase (iron chelators) in the level of transferrin receptors synthesis.	Iron	90-94	transferrin	Homo sapiens	122-133
2985429-5	1985	These results suggest that iron salts modulate the synthesis of transferrin receptors and ferritin via different molecular mechanisms, of transcriptional and translation type, respectively.	Iron	27-31	transferrin	Homo sapiens	64-75
2989537-1	1985	An equal mixture of oxidized and reduced cytochrome c551 experiences a change in the potential of the haem iron when one of the propionates attached to the haem is ionized.	Iron	107-111	cytochrome c, somatic	Homo sapiens	41-53
3978231-0	1985	Regulation of heme synthesis in erythroid cells: hemin inhibits transferrin iron utilization but not protoporphyrin synthesis.	Iron	76-80	transferrin	Homo sapiens	64-75
3978231-2	1985	However, since heme inhibits erythroid cell uptake of iron from transferrin, we have tested the hypothesis that in reticulocytes heme regulates its own synthesis by controlling the cellular acquisition of iron from transferrin rather than by controlling the synthesis of ALA.	Iron	54-58	transferrin	Homo sapiens	64-75
3978231-7	1985	This suggests that some step (or steps) in the pathway of iron from extracellular transferrin to protoporphyrin limits the overall rate of heme synthesis in reticulocytes.	Iron	58-62	transferrin	Homo sapiens	82-93
3978231-8	1985	In addition, hemin in concentrations that inhibit the utilization of transferrin-bound iron for heme synthesis has no effect on the incorporation of iron from Fe-PBH into heme.	Iron	87-91	transferrin	Homo sapiens	69-80
3978231-9	1985	Our results indicate that in reticulocytes heme inhibits and controls the utilization of iron from transferrin but has no effect on the enzymes of porphyrin biosynthesis and ferrochelatase.	Iron	89-93	transferrin	Homo sapiens	99-110
3872264-0	1985	Haemophilus influenzae can use human transferrin as a sole source for required iron.	Iron	79-83	transferrin	Homo sapiens	37-48
3872264-2	1985	Iron starvation could be overcome in each of 33 H. influenzae type b isolates by 30% Fe-saturated human transferrin but not by human lactoferrin.	Iron	0-4	transferrin	Homo sapiens	104-115
3872264-2	1985	Iron starvation could be overcome in each of 33 H. influenzae type b isolates by 30% Fe-saturated human transferrin but not by human lactoferrin.	Iron	85-87	transferrin	Homo sapiens	104-115
2863261-9	1985	These results indicated that iron was removed from transferrin at an intracellular site in an acidic environment.	Iron	29-33	transferrin	Rattus norvegicus	51-62
3990535-2	1985	It was shown that the oral route of the entry of appropriate amounts of iron in the body made it possible to saturate the transferrin spare capacity and hence to influence 239Pu metabolism in the blood.	Iron	72-76	transferrin	Homo sapiens	122-133
2996611-2	1985	Isolated rat liver mitochondria accumulate iron from fully saturated transferrin at neutral pH.	Iron	43-47	transferrin	Rattus norvegicus	69-80
2985960-0	1985	Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells.	Iron	35-39	transferrin	Homo sapiens	63-74
2996611-3	1985	With 5 microM iron as diferric transferrin, accumulation at 30 degrees C amounts to approx.	Iron	14-18	transferrin	Rattus norvegicus	31-42
2996611-6	1985	Vacant iron-binding sites on mono- and apotransferrin compete with the mitochondria for iron mobilized from transferrin.	Iron	7-11	transferrin	Rattus norvegicus	42-53
2996611-6	1985	Vacant iron-binding sites on mono- and apotransferrin compete with the mitochondria for iron mobilized from transferrin.	Iron	88-92	transferrin	Rattus norvegicus	42-53
2982414-10	1985	The similarity in Raman spectra for myeloperoxidase and green haemoprotein indicates that the two iron sites in myeloperoxidase are equivalent.	Iron	98-102	myeloperoxidase	Homo sapiens	36-51
2988111-4	1985	The results obtained thus indicate that the observed increase in transferrin receptors is not a secondary phenomenon due to systemic iron overload but could be an expression of a primary inborn error of iron metabolism in HH.	Iron	133-137	transferrin	Homo sapiens	65-76
18963849-1	1985	Iron-52 can be separated from solutions of chromium cyclotron targets by eluting chromium, copper and radioactive impurities with 9.0M hydrochloric acid from a column containing 1.0 g of AG1-X2 anion-exchange resin.	Iron	0-4	NBPF member 10	Homo sapiens	187-190
2992542-1	1985	We have studied the behaviour of Fe(III) cytochrome c upon irradiation in the 290-360 nm wavelength range either in the presence or in the absence of NADH; in both cases the photoexcitation caused the reduction of the heme iron.	Iron	223-227	cytochrome c, somatic	Homo sapiens	41-53
2982414-10	1985	The similarity in Raman spectra for myeloperoxidase and green haemoprotein indicates that the two iron sites in myeloperoxidase are equivalent.	Iron	98-102	myeloperoxidase	Homo sapiens	112-127
3970972-0	1985	Reduction potential of iron in transferrin.	Iron	23-27	transferrin	Homo sapiens	31-42
3971047-4	1985	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDB) were shown to increase the rates of iron and transferrin uptake by reticulocytes and fetal liver erythroid cells by accelerating the rates of transferrin endocytosis and exocytosis.	Iron	129-133	transferrin	Rattus norvegicus	235-246
3977940-2	1985	We have reported previously that both dietary iron and selenium regulate intestinal cytochrome P-450 content by modulating the synthesis of its prosthetic heme moiety.	Iron	46-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	84-100
3968194-6	1985	Only this internalized transferrin was capable of donating iron to the cells.	Iron	59-63	transferrin	Rattus norvegicus	23-34
2981898-0	1985	Regulation of K562 cell transferrin receptors by exogenous iron.	Iron	59-63	transferrin	Homo sapiens	24-35
2981898-1	1985	Single-cell analysis of K562 human erythroleukemia cells by flow cytometry was used to demonstrate the specific role of iron in regulating transferrin receptors (TfRs) and to establish that TfR expression does not necessarily correlate with growth rate.	Iron	120-124	transferrin	Homo sapiens	139-150
2981898-2	1985	Exogenous iron concentration in culture was manipulated by supplementing the medium with sera having different iron concentrations over the range 0.6 to 5.4 micrograms/ml, by the addition of iron in the form of FeCl3, iron-saturated serum, or diferric transferrin, and by the addition of the iron chelator Desferal (desferrioxamine).	Iron	10-14	transferrin	Homo sapiens	252-263
3971051-1	1985	The uptake of iron from a tied off jejunal segment into the body after the injection of a 59Fe labeled test dose was decreased after the administration of endotoxin by about 80% in both normal and iron deficient animals.--In the iron deficient group the distribution of 59Fe in the cytosol fraction of jejunal mucosa between transferrin and ferritin was determined chromatographically; the amount of 59Fe in the ferritin fraction increased remarkably after the endotoxin treatment and the ratio of both was changed in favor of ferritin.--It is hypothesized that the association of the diversion of iron to the mucosal ferritin with the decrease of the transport of iron into the blood caused by endotoxin might be the consequence of abnormal oxidations in the mucosa measured by others in liver tissue.	Iron	14-18	transferrin	Homo sapiens	325-336
2984253-16	1985	We conclude that human leukemia cells require Fe for growth and that 42/6 inhibits transferrin-dependent cells by Fe deprivation.	Iron	114-116	transferrin	Homo sapiens	83-94
3966565-4	1985	These results suggest that at least part of iron uptake by hepatocytes is mediated by the reversible binding of transferrin in a manner comparable with erythroid cells and placenta.	Iron	44-48	transferrin	Rattus norvegicus	112-123
2986063-0	1985	Transferrin and its cellular receptor underscore the importance of iron in cell growth.	Iron	67-71	transferrin	Homo sapiens	0-11
3919527-3	1985	The complete inhibition of the process by hydroxyl radical scavengers, superoxide dismutase and catalase, indicated an iron-catalyzed Haber-Weiss reaction for the generation of hydroxyl radicals that subsequently react with the nucleic acid.	Iron	119-123	catalase	Oryctolagus cuniculus	96-104
3935281-2	1985	In these conditions, diferric lactotransferrin and iron-free lactotransferrin are reversibly bound with the following parameters: association constant Ka = 2 and 5 X 10(6) M-1, respectively, and the number of binding sites N = 1.2 and 1 X 10(7), respectively.	Iron	51-55	lactotransferrin	Homo sapiens	61-77
3935281-4	1985	In the same conditions, the binding of serotransferrin (Ka = 2 X 10(7) M-1 and 1.6 X 10(7) M-1; N = 5 X 10(4) and 8 X 10(4) for diferric and iron-free protein, respectively) was not inhibited.	Iron	141-145	transferrin	Homo sapiens	39-54
3896889-1	1985	Receptor mediated endocytosis has been proposed as the method of cellular iron uptake from transferrin (TF).	Iron	74-78	transferrin	Homo sapiens	104-106
3995974-0	1985	Transferrin-mediated iron transport in the perfused isolated human placental lobule.	Iron	21-25	transferrin	Homo sapiens	0-11
3157637-5	1985	Since transferrin (iron) is known to catalyze the formation of hydroxyl radicals we hypothesize that the Tf C2 variant is more efficient in promoting radical formation and thereby cell damage.	Iron	19-23	transferrin	Homo sapiens	6-17
3896889-4	1985	It may be, that under appropriate physiological conditions (e.g. degree of iron saturation of TF) cells may take up iron by either an endocytotic or nonendocytotic mechanism.	Iron	75-79	transferrin	Homo sapiens	94-96
3896889-0	1985	Cellular iron uptake from transferrin: is endocytosis the only mechanism?	Iron	9-13	transferrin	Homo sapiens	26-37
3896889-1	1985	Receptor mediated endocytosis has been proposed as the method of cellular iron uptake from transferrin (TF).	Iron	74-78	transferrin	Homo sapiens	91-102
3896889-4	1985	It may be, that under appropriate physiological conditions (e.g. degree of iron saturation of TF) cells may take up iron by either an endocytotic or nonendocytotic mechanism.	Iron	116-120	transferrin	Homo sapiens	94-96
2856926-6	1985	Together with the previous data on the immunocytochemical localization of transferrin, these results suggest that the transferrin receptor may constitutively enter and exit KB cells by endocytosis and exocytosis, carrying bound transferrin into and out of the cell for the purpose of supplying iron from the extracellular environment for cell growth.	Iron	294-298	transferrin	Homo sapiens	74-85
2993056-7	1985	Iron is accumulated via both receptor systems in the heterologous system, but only via the transferrin receptors in the homologous system.	Iron	0-4	transferrin	Rattus norvegicus	91-102
4086199-3	1985	A separation of the albumin- and transferrin-proteins by ion-exchange chromatography using DEAE-cellulose showed the 239Np being entirely bound to the iron-carrier protein transferrin.	Iron	151-155	transferrin	Rattus norvegicus	33-44
4086199-3	1985	A separation of the albumin- and transferrin-proteins by ion-exchange chromatography using DEAE-cellulose showed the 239Np being entirely bound to the iron-carrier protein transferrin.	Iron	151-155	transferrin	Rattus norvegicus	172-183
4086199-5	1985	The binding capacity of transferrin for neptunium in vivo was found to decline when the iron level in blood serum was increased.	Iron	88-92	transferrin	Rattus norvegicus	24-35
3011819-1	1985	Transferrin is the major iron carrier protein in vertebrates and is required for maintenance of cell viability.	Iron	25-29	transferrin	Homo sapiens	0-11
3011819-2	1985	To deliver iron, transferrin binds to its receptor, the complex is internalized and directed into acidic vacuoles where iron is dissociated and the ligand-receptor complex is recycled back to the plasma membrane.	Iron	11-15	transferrin	Homo sapiens	17-28
3011819-2	1985	To deliver iron, transferrin binds to its receptor, the complex is internalized and directed into acidic vacuoles where iron is dissociated and the ligand-receptor complex is recycled back to the plasma membrane.	Iron	120-124	transferrin	Homo sapiens	17-28
3011821-1	1985	The distribution of cell surface receptors for transferrin-iron and epidermal growth factor (EGF) on the surface of cultured epithelioid (A431) cells has been identified by immunocytochemical electron microscopy.	Iron	59-63	transferrin	Homo sapiens	47-58
2856926-6	1985	Together with the previous data on the immunocytochemical localization of transferrin, these results suggest that the transferrin receptor may constitutively enter and exit KB cells by endocytosis and exocytosis, carrying bound transferrin into and out of the cell for the purpose of supplying iron from the extracellular environment for cell growth.	Iron	294-298	transferrin	Homo sapiens	118-129
2856926-6	1985	Together with the previous data on the immunocytochemical localization of transferrin, these results suggest that the transferrin receptor may constitutively enter and exit KB cells by endocytosis and exocytosis, carrying bound transferrin into and out of the cell for the purpose of supplying iron from the extracellular environment for cell growth.	Iron	294-298	transferrin	Homo sapiens	118-129
6543331-2	1984	The association of a low serum iron level and a normal blood haemoglobin suggested an abnormality of transferrin too.	Iron	31-35	transferrin	Homo sapiens	101-112
6095919-0	1984	Transferrin as a donor of iron to mitochondria.	Iron	26-30	transferrin	Homo sapiens	0-11
6095919-2	1984	Rat liver mitochondria accumulate iron mobilized from transferrin by pyrophosphate.	Iron	34-38	transferrin	Homo sapiens	54-65
6597996-2	1984	Positive TF reactivity has been related to iron transport, epithelial keratinization, and the non-specific defense system of mucosal membranes.	Iron	43-47	transferrin	Homo sapiens	9-11
6517927-0	1984	Iron uptake from transferrin by isolated hepatocytes: effect of ethanol.	Iron	0-4	transferrin	Rattus norvegicus	17-28
6517927-3	1984	These data are compatible with the hypothesis that iron uptake from transferrin by hepatocytes is mediated by a pH dependent transferrin receptor mechanism similar to that in reticulocytes.	Iron	51-55	transferrin	Rattus norvegicus	68-79
6517927-3	1984	These data are compatible with the hypothesis that iron uptake from transferrin by hepatocytes is mediated by a pH dependent transferrin receptor mechanism similar to that in reticulocytes.	Iron	51-55	transferrin	Rattus norvegicus	125-136
6519118-3	1984	Iron replete children showed a gradual rise in serum iron and transferrin saturation values with age.	Iron	0-4	transferrin	Homo sapiens	62-73
6442209-7	1984	When microsomes from untreated, phenobarbital-treated (3 days), or TCDD-treated (1 or 3 weeks) rats were compared, iron release correlated most closely with the cytochrome P-450 concentration.	Iron	115-119	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	161-177
6519641-1	1984	Up until recently in clinical practice suspected hemochromatosis with a pathological iron-screening test (plasma iron, percentage transferrin saturation, serum ferritin, desferrioxamine-induced urinary iron excretion) made a liver biopsy necessary.	Iron	85-89	transferrin	Homo sapiens	130-141
6519118-4	1984	Serum iron and transferrin saturation values were lower (P less than 0.001, P less than 0.0001) and transferrin values higher (P less than 0.0001) in iron replete children compared to adults.	Iron	150-154	transferrin	Homo sapiens	100-111
6519118-5	1984	Iron replete children had a 2.5 centile transferrin saturation value of 5%; 19.9% of these children had saturation values less than 15% and 8.2% had values less than 10%.	Iron	0-4	transferrin	Homo sapiens	40-51
6519118-6	1984	In iron depleted children a transferrin saturation value less than 7% yielded the highest diagnostic efficiency as regards exhausted iron stores, although with a low predictive value of a positive test.	Iron	3-7	transferrin	Homo sapiens	28-39
6519118-6	1984	In iron depleted children a transferrin saturation value less than 7% yielded the highest diagnostic efficiency as regards exhausted iron stores, although with a low predictive value of a positive test.	Iron	133-137	transferrin	Homo sapiens	28-39
6437703-0	1984	Are usual immunochemical methods for the determination of human serum transferrin influenced by the iron-saturation of the protein?	Iron	100-104	transferrin	Homo sapiens	70-81
6092356-0	1984	Effect of iron chelators on the transferrin receptor in K562 cells.	Iron	10-14	transferrin	Homo sapiens	32-43
6093705-8	1984	+ Fe3+ (chelate)----Fe2+ (chelate) + PQ++ H2O2 + Fe2+ (chelate)----Fe3+ (chelate) + OH- + OH.. Iron-(EDTA) and iron-(diethylenetriaminepentaacetic acid) (DTPA) were good catalysts of the reaction; iron complexed with desferrioxamine or transferrin was not.	Iron	95-99	transferrin	Homo sapiens	236-247
6092356-1	1984	Delivery of iron to K562 cells by diferric transferrin involves a cycle of binding to surface receptors, internalization into an acidic compartment, transfer of iron to ferritin, and release of apotransferrin from the cell.	Iron	12-16	transferrin	Homo sapiens	43-54
6092375-4	1984	Partially saturated transferrin and lactoferrin present in normal subjects may protect cells from damage by binding iron that might catalyze hydroxyl radical formation from superoxide and hydrogen peroxide.	Iron	116-120	transferrin	Homo sapiens	20-31
6092356-1	1984	Delivery of iron to K562 cells by diferric transferrin involves a cycle of binding to surface receptors, internalization into an acidic compartment, transfer of iron to ferritin, and release of apotransferrin from the cell.	Iron	161-165	transferrin	Homo sapiens	43-54
6092356-3	1984	In the present study, we found that chelation of extracellular iron by the hydrophilic chelators desferrioxamine B, diethylenetriaminepentaacetic acid, or apolactoferrin enhanced the release from the cells of previously internalized 125I-transferrin.	Iron	63-67	transferrin	Homo sapiens	238-249
6095085-5	1984	It is possible that transferrin receptors are expressed on these cells to allow transport of transferrin (and thus iron) into brain tissues.	Iron	115-119	transferrin	Rattus norvegicus	20-31
6092356-12	1984	We conclude that the transferrin receptor in the K562 cell is regulated in part by chelatable iron: chelation of extracellular iron enhances the release of apotransferrin from the cell, while chelation of an intracellular iron pool results in the biosynthesis of new receptors.	Iron	94-98	transferrin	Homo sapiens	21-32
6092356-12	1984	We conclude that the transferrin receptor in the K562 cell is regulated in part by chelatable iron: chelation of extracellular iron enhances the release of apotransferrin from the cell, while chelation of an intracellular iron pool results in the biosynthesis of new receptors.	Iron	127-131	transferrin	Homo sapiens	21-32
6092356-12	1984	We conclude that the transferrin receptor in the K562 cell is regulated in part by chelatable iron: chelation of extracellular iron enhances the release of apotransferrin from the cell, while chelation of an intracellular iron pool results in the biosynthesis of new receptors.	Iron	127-131	transferrin	Homo sapiens	21-32
6092369-1	1984	The number of diferic transferrin receptors on HeLa cells decreases when cells are grown in iron-supplemented media.	Iron	92-96	transferrin	Homo sapiens	22-33
6092369-3	1984	When HeLa cells were grown in the presence of hemin, transferrin receptor number decreased to a greater degree than when cells were grown in equivalent amounts of iron supplied as ferric ammonium citrate.	Iron	163-167	transferrin	Homo sapiens	53-64
6096996-1	1984	Kinetics of the content of nonheme iron-sulphur-containing (iron-sulphur) proteins, free radicals of electron-transport mitochondrial system, as well as of microsome terminal oxidase cytochrome P-450 is studied in the liver of rats at early stages of carcinogenesis and in the process of tumour growth induced by intratracheal administration of various benz(a)pyrene doses.	Iron	35-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	183-199
6437260-0	1984	Transferrin level derived from total iron-binding capacity: is it a reliable relationship?	Iron	37-41	transferrin	Homo sapiens	0-11
6496771-3	1984	The 55Fe-colloid was cleared almost immediately, and its iron was rapidly released to bind to plasma transferrin.	Iron	57-61	transferrin	Homo sapiens	101-112
6090955-1	1984	In vertebrates all iron is taken up via the carrier protein transferrin.	Iron	19-23	transferrin	Homo sapiens	60-71
6090189-2	1984	Induction is accompanied by increased transferrin-binding activity which is necessary for the cellular acquisition of iron from transferrin for hemoglobin synthesis.	Iron	118-122	transferrin	Homo sapiens	38-49
6487660-1	1984	The inhibitory effect of heme on iron uptake from transferrin by rat and rabbit reticulocytes and erythroid cells from the fetal rat liver was studied in vitro.	Iron	33-37	transferrin	Rattus norvegicus	50-61
6487660-2	1984	Addition of hemin was shown to cause a decrease in the rate of transferrin endocytosis, the degree of inhibition being proportional to the reduction in iron uptake.	Iron	152-156	transferrin	Rattus norvegicus	63-74
6487660-4	1984	It is concluded from these results that heme affects iron uptake by influencing the rate of transferrin endocytosis and recycling.	Iron	53-57	transferrin	Rattus norvegicus	92-103
6089933-1	1984	The transferrin iron transport system, along with its procurement sites and delivery receptors, provides a highly effective means of satisfying internal iron requirements.	Iron	16-20	transferrin	Homo sapiens	4-15
6089933-1	1984	The transferrin iron transport system, along with its procurement sites and delivery receptors, provides a highly effective means of satisfying internal iron requirements.	Iron	153-157	transferrin	Homo sapiens	4-15
6089933-2	1984	Iron uptake by individual tissues is determined by their receptor number, by the relative amounts of monoferric and diferric transferrin in circulation, and by the amount of available iron in donor tissues.	Iron	0-4	transferrin	Homo sapiens	125-136
6090189-2	1984	Induction is accompanied by increased transferrin-binding activity which is necessary for the cellular acquisition of iron from transferrin for hemoglobin synthesis.	Iron	118-122	transferrin	Homo sapiens	128-139
6592167-5	1984	Iron containing compounds, such as hemin or hemoglobin, were also able to replace transferrin.	Iron	0-4	transferrin	Homo sapiens	82-93
6091257-1	1984	Transferrin-mediated uptake of iron has been studied in K-562 human erythroleukaemia cells.	Iron	31-35	transferrin	Homo sapiens	0-11
6592293-2	1984	The results indicate that: (a) the liver can take up Ga-67 and secrete it into the bile, even in the absence of transferrin; (b) transferrin inhibits hepatic uptake of Ga-67 and its biliary excretion; and (c) iron deficiency markedly enhances hepatic uptake of Ga-67.	Iron	209-213	transferrin	Rattus norvegicus	129-140
6091257-2	1984	K-562 cells accumulate iron from transferrin by a temperature-dependent mechanism linearly with time for at least 150 min.	Iron	23-27	transferrin	Homo sapiens	33-44
6091257-3	1984	At 37 degrees C the uptake reaches a saturation level of approximately 25 pmol iron/10(6) cells/h at a concentration of iron (as iron-transferrin) of 5 mumol/l.	Iron	79-83	transferrin	Homo sapiens	134-145
6091257-3	1984	At 37 degrees C the uptake reaches a saturation level of approximately 25 pmol iron/10(6) cells/h at a concentration of iron (as iron-transferrin) of 5 mumol/l.	Iron	120-124	transferrin	Homo sapiens	134-145
6091257-5	1984	Relative to the binding of transferrin the uptake of iron increases with time.	Iron	53-57	transferrin	Homo sapiens	27-38
6091257-7	1984	The results are compatible with iron uptake by receptor-mediated endocytosis of transferrin, dissociation of iron within the cell and exocytosis of apotransferrin.	Iron	32-36	transferrin	Homo sapiens	80-91
6437438-3	1984	From experiments correlating changes in the rate of fast-phase reduction with the spin state of the heme iron existing at preequilibrium, data were obtained consistent with a model for spin-state control of cytochrome P-450 reduction wherein the high-spin form of the hemoprotein is more rapidly reduced than the low-spin form.	Iron	105-109	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	207-223
6091554-12	1984	This suggestion implies that the electron distribution of the iron at the catalytic sites of cytochrome P-450 and certain chlorin-containing enzymes is in some way similar, but distinct from that at the transport site of myoglobin.	Iron	62-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	93-109
6487298-8	1984	We conclude that haptoglobin serves to conserve the iron of hemoglobin by preventing its renal clearance and not by promoting its hepatic uptake.	Iron	52-56	haptoglobin	Rattus norvegicus	17-28
6478224-6	1984	Muscles denervated for 7 days and injected daily with 1 of several doses of iron-conjugated rat transferrin exhibited a rate of atrophy equivalent to that in denervated muscles that either were not treated or were injected with saline.	Iron	76-80	transferrin	Rattus norvegicus	96-107
6465095-3	1984	Six of 22 heterozygotes for thalassemias had elevated EP, and all of these had transferrin iron saturation of less than 16%, reflecting a complicating iron deficiency.	Iron	91-95	transferrin	Homo sapiens	79-90
6465095-5	1984	These elevated EP levels were associated with transferrin iron saturation between 18 and 44%.	Iron	58-62	transferrin	Homo sapiens	46-57
6465095-8	1984	This relative iron deficiency in thalassemia occurs at a transferrin iron saturation level usually considered to be normal.	Iron	14-18	transferrin	Homo sapiens	57-68
6745616-6	1984	We conclude that the combination of serum ferritin and transferrin saturation is a reliable screening regimen for the detection of hemochromatosis and for predicting the level of body iron stores in young hemochromatosis subjects.	Iron	184-188	transferrin	Homo sapiens	55-66
6436525-2	1984	Serum transferrin was derived from total iron-binding capacity measurements in 74 patients on 114 occasions and correlated with body composition as measured by multiple isotope dilution.	Iron	41-45	transferrin	Homo sapiens	6-17
6387157-7	1984	We found that a mixture of insulin, thyroid hormone, testosterone, and the iron-binding protein transferrin maintained levels of protein synthesis in myocardial cell cultures near the levels achieved with fetal bovine serum supplement, and reduced catabolism of proteins measured directly and by monitoring net changes in protein levels in the cultures.	Iron	75-79	transferrin	Homo sapiens	96-107
6087921-7	1984	The results are strong evidence that the major part of iron uptake by hepatocytes occurs from transferrin bound to the plasma membrane transferrin receptor.	Iron	55-59	transferrin	Homo sapiens	94-105
6087921-7	1984	The results are strong evidence that the major part of iron uptake by hepatocytes occurs from transferrin bound to the plasma membrane transferrin receptor.	Iron	55-59	transferrin	Homo sapiens	135-146
6465342-1	1984	Observations on iron uptake by reticulocytes led Fletcher and Huehns to suggest differences in the behavior of the two iron-binding sites of the transferrin molecule.	Iron	16-20	transferrin	Homo sapiens	145-156
6438073-8	1984	The ferrous 688-nm substance was degraded to a biliverdin-iron complex much more rapidly in the presence of the NADPH-cytochrome P-450 reductase system than in its absence, indicating that a reducing equivalent is essential for the initiation of heme degradation even when starting from the ferrous 688-nm substance.	Iron	58-62	cytochrome p450 oxidoreductase	Homo sapiens	112-144
6481356-0	1984	Kinetics of the removal of ferric ion from transferrin by aminoalkylphosphonic acids.	Iron	27-37	transferrin	Homo sapiens	43-54
6481356-2	1984	The initial rate of iron removal is first order in ferric-transferrin, but shows a hyperbolic dependence on the concentration of the phosphonate ligand.	Iron	20-24	transferrin	Homo sapiens	58-69
6481356-3	1984	At high ligand concentrations the reaction is clearly biphasic, and the data are interpreted in terms of nonequivalent rate constants for iron removal from the two transferrin iron-binding sites.	Iron	138-142	transferrin	Homo sapiens	164-175
6481356-3	1984	At high ligand concentrations the reaction is clearly biphasic, and the data are interpreted in terms of nonequivalent rate constants for iron removal from the two transferrin iron-binding sites.	Iron	176-180	transferrin	Homo sapiens	164-175
6481356-5	1984	The results are discussed in relation to the conformational change mechanism for iron removal from transferrin proposed by Coward et al.	Iron	81-85	transferrin	Homo sapiens	99-110
6747728-0	1984	Retention and distribution of iron added to cow"s milk and human milk as various salts and chelates.	Iron	30-34	Weaning weight-maternal milk	Bos taurus	50-54
6747728-0	1984	Retention and distribution of iron added to cow"s milk and human milk as various salts and chelates.	Iron	30-34	Weaning weight-maternal milk	Bos taurus	65-69
6747728-8	1984	Iron from FeCl2, FeSO4 and FeNTA were the best retained from both milk diets.	Iron	0-4	Weaning weight-maternal milk	Bos taurus	66-70
6747728-10	1984	Iron bioavailability was higher from the human milk diets than from the cow"s milk diets from all vehicles used except citrate and lactobionate.	Iron	0-4	Weaning weight-maternal milk	Bos taurus	47-51
6747728-10	1984	Iron bioavailability was higher from the human milk diets than from the cow"s milk diets from all vehicles used except citrate and lactobionate.	Iron	0-4	Weaning weight-maternal milk	Bos taurus	78-82
6465342-1	1984	Observations on iron uptake by reticulocytes led Fletcher and Huehns to suggest differences in the behavior of the two iron-binding sites of the transferrin molecule.	Iron	119-123	transferrin	Homo sapiens	145-156
6465342-4	1984	Isoelectric focusing procedures and electrophoresis in urea gels revealed that the conspicuous difference in the amount of iron uptake is the result of differences in the proportion of di- to monoferric transferrin in the two plasmas and the competitive advantage of the diferric moiety.	Iron	123-127	transferrin	Homo sapiens	203-214
6465342-5	1984	These studies provide an explanation for the Fletcher-Huehns phenomenon without invoking functional differences between the two sites for iron on the transferrin molecule.	Iron	138-142	transferrin	Homo sapiens	150-161
6465688-6	1984	Attempts by bacteria to tear iron from serum transferrin with siderophores, iron binding compounds may be blocked with host lactoferrins that have an even higher affinity for the iron.	Iron	29-33	transferrin	Homo sapiens	45-56
6465688-6	1984	Attempts by bacteria to tear iron from serum transferrin with siderophores, iron binding compounds may be blocked with host lactoferrins that have an even higher affinity for the iron.	Iron	76-80	transferrin	Homo sapiens	45-56
6465688-6	1984	Attempts by bacteria to tear iron from serum transferrin with siderophores, iron binding compounds may be blocked with host lactoferrins that have an even higher affinity for the iron.	Iron	76-80	transferrin	Homo sapiens	45-56
6331503-2	1984	The capacity of the mitochondria to accumulate iron is higher than the capacity of pyrophosphate to mobilize iron from transferrin: with ferric-iron-pyrophosphate as iron donor, iron uptake and heme synthesis are about 10-times that at corresponding concentrations of iron-transferrin plus pyrophosphate.	Iron	109-113	transferrin	Homo sapiens	119-130
6096463-1	1984	It has been postulated that the process of iron transfer to the human fetus begins with the binding of maternal transferrin-iron complexes to placental transferrin receptors.	Iron	43-47	transferrin	Homo sapiens	112-123
6096463-1	1984	It has been postulated that the process of iron transfer to the human fetus begins with the binding of maternal transferrin-iron complexes to placental transferrin receptors.	Iron	43-47	transferrin	Homo sapiens	152-163
6096463-1	1984	It has been postulated that the process of iron transfer to the human fetus begins with the binding of maternal transferrin-iron complexes to placental transferrin receptors.	Iron	124-128	transferrin	Homo sapiens	112-123
6096463-1	1984	It has been postulated that the process of iron transfer to the human fetus begins with the binding of maternal transferrin-iron complexes to placental transferrin receptors.	Iron	124-128	transferrin	Homo sapiens	152-163
6096463-8	1984	Thymidine uptake and native hCG secretion in choriocarcinoma cell lines increased with transferrin-iron addition to these mediums (but no increase in the beta-hCG secretion in the medium was observed).	Iron	99-103	transferrin	Homo sapiens	87-98
6331503-1	1984	Rat liver mitochondria accumulate iron mobilized from transferrin by pyrophosphate.	Iron	34-38	transferrin	Rattus norvegicus	54-65
6331503-2	1984	The capacity of the mitochondria to accumulate iron is higher than the capacity of pyrophosphate to mobilize iron from transferrin: with ferric-iron-pyrophosphate as iron donor, iron uptake and heme synthesis are about 10-times that at corresponding concentrations of iron-transferrin plus pyrophosphate.	Iron	109-113	transferrin	Homo sapiens	119-130
6331503-2	1984	The capacity of the mitochondria to accumulate iron is higher than the capacity of pyrophosphate to mobilize iron from transferrin: with ferric-iron-pyrophosphate as iron donor, iron uptake and heme synthesis are about 10-times that at corresponding concentrations of iron-transferrin plus pyrophosphate.	Iron	109-113	transferrin	Homo sapiens	119-130
6466333-1	1984	Reaction of H2O2 with iron containing superoxide dismutase (SOD) was studied by absorption spectroscopy, activity measurement and amino acid analysis.	Iron	22-26	superoxide dismutase 1	Homo sapiens	38-58
6466333-1	1984	Reaction of H2O2 with iron containing superoxide dismutase (SOD) was studied by absorption spectroscopy, activity measurement and amino acid analysis.	Iron	22-26	superoxide dismutase 1	Homo sapiens	60-63
6330553-1	1984	We report a case of anemia due to autoantibodies to the transferrin receptor interfering with iron incorporation by erythroid progenitors.	Iron	94-98	transferrin	Homo sapiens	56-67
6086614-13	1984	Atomic absorption spectroscopy revealed nearly stoichiometric amounts of tightly bound Fe and Zn (but little other ions) on purified calcineurin, which remained bound during the calmodulin-dependent deactivation; removal of tightly bound metals is, therefore, not the cause of deactivation.	Iron	87-89	calmodulin 1	Homo sapiens	178-188
6330553-7	1984	Binding of [59Fe]transferrin or fluorescent iron transferrin was not diminished by the patient"s serum at 4 degrees C, but at 37 degrees C uptake was markedly reduced, as was the binding of fluorescent monoclonal antibodies to either surface transferrin or the human transferrin receptor.	Iron	44-48	transferrin	Homo sapiens	49-60
6330553-7	1984	Binding of [59Fe]transferrin or fluorescent iron transferrin was not diminished by the patient"s serum at 4 degrees C, but at 37 degrees C uptake was markedly reduced, as was the binding of fluorescent monoclonal antibodies to either surface transferrin or the human transferrin receptor.	Iron	44-48	transferrin	Homo sapiens	49-60
6330553-7	1984	Binding of [59Fe]transferrin or fluorescent iron transferrin was not diminished by the patient"s serum at 4 degrees C, but at 37 degrees C uptake was markedly reduced, as was the binding of fluorescent monoclonal antibodies to either surface transferrin or the human transferrin receptor.	Iron	44-48	transferrin	Homo sapiens	49-60
6465862-5	1984	The addition of either methylamine or ammonium chloride, both known blockers of transferrin-iron release through their lysosomotropic properties, inhibited total iron uptake.	Iron	92-96	transferrin	Homo sapiens	80-91
6547607-7	1984	These results are analyzed in the light of the evidence that transferrin is not only an iron-binding protein, but also a factor involved in cell proliferation and differentiation, and particularly in nerve control of muscle differentiation.	Iron	88-92	transferrin	Rattus norvegicus	61-72
6734743-0	1984	Iron uptake by Chinese hamster fibroblasts from human transferrin.	Iron	0-4	transferrin	Homo sapiens	54-65
6734743-1	1984	The manner of uptake or iron by Chinese hamster fibroblasts, type DON, from human transferrin was investigated by means of replacement studies, in which the cells that were incubated with 125I-labelled human transferrin were chased with non-radioactive transferrin for only a few minutes.	Iron	24-28	transferrin	Homo sapiens	82-93
6465862-5	1984	The addition of either methylamine or ammonium chloride, both known blockers of transferrin-iron release through their lysosomotropic properties, inhibited total iron uptake.	Iron	162-166	transferrin	Homo sapiens	80-91
6465862-6	1984	Methylamine also inhibited the rate of ferritin-iron incorporation, most likely by interfering with transferrin-iron release.	Iron	112-116	transferrin	Homo sapiens	100-111
6465862-7	1984	The data suggest that neuronal iron transport, much like that in other mammalian tissues, is transferrin mediated and that blockers of transferrin-iron release may be of value in conditions in which there is brain iron overload.	Iron	31-35	transferrin	Homo sapiens	93-104
6465862-7	1984	The data suggest that neuronal iron transport, much like that in other mammalian tissues, is transferrin mediated and that blockers of transferrin-iron release may be of value in conditions in which there is brain iron overload.	Iron	147-151	transferrin	Homo sapiens	135-146
6465862-7	1984	The data suggest that neuronal iron transport, much like that in other mammalian tissues, is transferrin mediated and that blockers of transferrin-iron release may be of value in conditions in which there is brain iron overload.	Iron	147-151	transferrin	Homo sapiens	135-146
6517520-4	1984	Serum ferritin rather than haemoglobin, serum iron and transferrin saturation is the most reliable indication of iron status of blood donors.	Iron	113-117	transferrin	Homo sapiens	55-66
6589596-0	1984	Occupancy of the iron binding sites of human transferrin.	Iron	17-21	transferrin	Homo sapiens	45-56
6589596-1	1984	The in vivo distribution of iron between the binding sites of transferrin was examined.	Iron	28-32	transferrin	Homo sapiens	62-73
6589596-5	1984	The data indicate that the distribution of apo-, monoferric, and diferric transferrins is predictable on the basis of the plasma transferrin saturation and negate the concept that iron loading of transferrin in vitro is a selective process with possible functional consequences in tissue iron delivery.	Iron	180-184	transferrin	Homo sapiens	74-85
6326850-0	1984	Uptake of iron from transferrin by isolated hepatocytes.	Iron	10-14	transferrin	Rattus norvegicus	20-31
6327697-6	1984	The observed isomer shift, delta = 0.96 mm/s at 4.2 K, shows that the P-460 iron is high spin ferrous.	Iron	76-80	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	70-75
6327697-8	1984	The iron of the oxidized P-460 fragment is high spin ferric, with Mossbauer and EPR parameters very similar to those of metmyoglobin.	Iron	4-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	25-30
6327697-11	1984	The spectroscopic and chemical evidence obtained to date suggests strongly that the P-460 iron resides in a heme-like macrocycle although the presumed porphyrin must have some unusual features.	Iron	90-94	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	84-89
6375346-0	1984	Transferrin in disease II: defects in the regulation of transferrin saturation with iron contribute to susceptibility to infection.	Iron	84-88	transferrin	Homo sapiens	0-11
6326850-1	1984	Isolated rat hepatocytes containing 0.56-1.79 micrograms iron/10(6) cells and with an intracellular ATP concentration of 3-4 mM, accumulate iron from transferrin linearly with time for at least 3 h. At 37 degrees C the rate of uptake amounts to 0.3-0.7 pmol/mg cell protein per min.	Iron	57-61	transferrin	Rattus norvegicus	150-161
6375346-0	1984	Transferrin in disease II: defects in the regulation of transferrin saturation with iron contribute to susceptibility to infection.	Iron	84-88	transferrin	Homo sapiens	56-67
6375346-1	1984	Patients with leukemia were found to have a high percentage of saturation of their serum transferrin with iron to an extent only rarely observed with other malignancies.	Iron	106-110	transferrin	Homo sapiens	89-100
6326850-1	1984	Isolated rat hepatocytes containing 0.56-1.79 micrograms iron/10(6) cells and with an intracellular ATP concentration of 3-4 mM, accumulate iron from transferrin linearly with time for at least 3 h. At 37 degrees C the rate of uptake amounts to 0.3-0.7 pmol/mg cell protein per min.	Iron	140-144	transferrin	Rattus norvegicus	150-161
6375346-4	1984	It was found that a high proportion of these patients also have a high saturation of their transferrin with iron.	Iron	108-112	transferrin	Homo sapiens	91-102
6326850-7	1984	The results suggest that iron uptake from transferrin by hepatocytes in suspension involves reductive removal of iron.	Iron	25-29	transferrin	Rattus norvegicus	42-53
6326850-7	1984	The results suggest that iron uptake from transferrin by hepatocytes in suspension involves reductive removal of iron.	Iron	113-117	transferrin	Rattus norvegicus	42-53
6234017-0	1984	Effect of serum albumin on siderophore-mediated utilization of transferrin iron.	Iron	75-79	albumin	Homo sapiens	10-23
6327764-4	1984	Partially saturated iron-binding proteins, such as transferrin and ferritin, are unable to catalyze OH.	Iron	20-24	transferrin	Homo sapiens	51-62
6747574-4	1984	Varying the concentrations of iron and transferrin in the medium gave results indicating that the glycoprotein"s trophic effect is due to its ability to furnish iron to the cells in an appropriate manner.	Iron	161-165	transferrin	Homo sapiens	39-50
6719116-1	1984	A fluorescently labeled estradiol, N"-fluoresceino-N"-(17 beta-estradiol hemisuccinamide) thiourea (FE) was used for measuring estrogen receptor content per cell in tumor cells.	Iron	100-102	estrogen receptor 1	Homo sapiens	127-144
6722176-0	1984	Characterization and localization of an iron-binding 18-kDa glycopeptide isolated from the N-terminal half of human lactotransferrin.	Iron	40-44	lactotransferrin	Homo sapiens	116-132
6722176-1	1984	Mild treatment of iron-saturated human lactotransferrin by trypsin at pH 8.2 cleaves the molecule into a N-tryptic (Mr approximately equal to 30000) and a C-tryptic (Mr approximately equal to 50000) fragment, which have been isolated.	Iron	18-22	lactotransferrin	Homo sapiens	39-55
6722176-4	1984	This fragment, the smallest iron-binding peptide isolated up to now from a transferrin, includes the ND2 domain of human lactotransferrin.	Iron	28-32	transferrin	Homo sapiens	75-86
6722176-4	1984	This fragment, the smallest iron-binding peptide isolated up to now from a transferrin, includes the ND2 domain of human lactotransferrin.	Iron	28-32	lactotransferrin	Homo sapiens	121-137
6725248-5	1984	The bound ferredoxin can interact with cytochrome c; the iron-sulfur cluster of the cross-linked complex is shown to be reduced under anaerobic conditions by NADPH and to be required for the catalysis of the NADPH-cytochrome c reductase reaction.	Iron	57-61	cytochrome c, somatic	Homo sapiens	39-51
6725248-5	1984	The bound ferredoxin can interact with cytochrome c; the iron-sulfur cluster of the cross-linked complex is shown to be reduced under anaerobic conditions by NADPH and to be required for the catalysis of the NADPH-cytochrome c reductase reaction.	Iron	57-61	cytochrome c, somatic	Homo sapiens	214-226
6234017-0	1984	Effect of serum albumin on siderophore-mediated utilization of transferrin iron.	Iron	75-79	transferrin	Homo sapiens	63-74
6234017-1	1984	The effect of serum and serum proteins on enterobactin- and aerobactin-mediated utilization of transferrin iron has been investigated.	Iron	107-111	transferrin	Homo sapiens	95-106
6234017-2	1984	Serum was found to impede transfer of iron from iron transferrin to enterobactin and from [55Fe]ferric enterobactin to cells of Escherichia coli BN3040 Na 1R iuc .	Iron	38-42	transferrin	Homo sapiens	53-64
6234017-5	1984	The inhibitory effect of human serum albumin on the enterobactin-mediated transfer of iron from [55Fe]transferrin was enhanced by preincubation of the protein with the siderophore.	Iron	86-90	albumin	Homo sapiens	31-44
6234017-5	1984	The inhibitory effect of human serum albumin on the enterobactin-mediated transfer of iron from [55Fe]transferrin was enhanced by preincubation of the protein with the siderophore.	Iron	86-90	transferrin	Homo sapiens	102-113
6234017-7	1984	A linear, reciprocal relationship was found to hold for human albumin concentration vs. the first-order rate constant ( kobsd ) for the velocity of iron transfer from iron transferrin to enterobactin.	Iron	148-152	transferrin	Homo sapiens	172-183
6234017-7	1984	A linear, reciprocal relationship was found to hold for human albumin concentration vs. the first-order rate constant ( kobsd ) for the velocity of iron transfer from iron transferrin to enterobactin.	Iron	167-171	transferrin	Homo sapiens	172-183
6234017-10	1984	These results indicate that serum albumin may act synergistically with other factors in the serum, such as transferrin, to limit iron supply and in this way restrict the growth of invading microorganisms.	Iron	129-133	albumin	Homo sapiens	28-41
6234017-10	1984	These results indicate that serum albumin may act synergistically with other factors in the serum, such as transferrin, to limit iron supply and in this way restrict the growth of invading microorganisms.	Iron	129-133	transferrin	Homo sapiens	107-118
6377946-6	1984	We suggest that the increased capacity of transferrin deficient in sialic acid to selectively deposit iron in the hepatocyte may be of significance for the development of the hepatic siderosis observed in alcoholism.	Iron	102-106	transferrin	Rattus norvegicus	42-53
6720680-0	1984	Monocyte transferrin-iron uptake in hereditary hemochromatosis.	Iron	21-25	transferrin	Homo sapiens	9-20
6429364-0	1984	Relationships between serum total iron-binding capacity and transferrin.	Iron	34-38	transferrin	Homo sapiens	60-71
6720680-1	1984	Transferrin-iron uptake by peripheral blood monocytes was studied in vitro to test the hypothesis that the relative paucity of mononuclear phagocyte iron loading in hereditary hemochromatosis results from a defect in uptake of iron from transferrin.	Iron	12-16	transferrin	Homo sapiens	0-11
6429364-1	1984	The relationship between serum transferrin ( TFN ) and serum total iron-binding capacity (TIBC) in a clinical setting was evaluated in two related studies.	Iron	67-71	transferrin	Homo sapiens	31-42
6429364-1	1984	The relationship between serum transferrin ( TFN ) and serum total iron-binding capacity (TIBC) in a clinical setting was evaluated in two related studies.	Iron	67-71	transferrin	Homo sapiens	45-48
6608955-1	1984	According to the Fletcher-Huehns hypothesis there exists a functional difference between the two iron-binding sites of transferrin.	Iron	97-101	transferrin	Homo sapiens	119-130
6431395-4	1984	Iron is an essential part of cytochrome C and alpha-glycerolphosphate dehydrogenase, and early stages of iron deficiency may, therefore, cause disturbances in tissue metabolism before development of anaemia.	Iron	0-4	cytochrome c, somatic	Homo sapiens	29-41
6585826-1	1984	Transferrin (Tf) is the major iron binding protein in vertebrate serum.	Iron	30-34	transferrin	Homo sapiens	0-11
6585826-1	1984	Transferrin (Tf) is the major iron binding protein in vertebrate serum.	Iron	30-34	transferrin	Homo sapiens	13-15
6324846-5	1984	As the variant transferrin has both abnormal iron-binding properties (Evans et al, 1982) and an abnormal interaction with the transferrin receptor, it would appear that these two functions may be closely interdependent.	Iron	45-49	transferrin	Homo sapiens	15-26
6608955-4	1984	Ferrokinetic studies in vivo, performed with both pure monoferric transferrins, showed that transferrin TfFeC, as well as transferrin FeNTf, mainly deliver their iron to the erythron.	Iron	162-166	transferrin	Homo sapiens	92-103
6608955-5	1984	As red cell 59Fe utilization, red cell iron turnover and other ferrokinetic parameters, obtained from this study, were identical too it is evident that both iron-binding sites of transferrin are functionally homogeneous in vivo, with respect to iron delivery.	Iron	39-43	transferrin	Homo sapiens	179-190
6608955-5	1984	As red cell 59Fe utilization, red cell iron turnover and other ferrokinetic parameters, obtained from this study, were identical too it is evident that both iron-binding sites of transferrin are functionally homogeneous in vivo, with respect to iron delivery.	Iron	157-161	transferrin	Homo sapiens	179-190
6608955-5	1984	As red cell 59Fe utilization, red cell iron turnover and other ferrokinetic parameters, obtained from this study, were identical too it is evident that both iron-binding sites of transferrin are functionally homogeneous in vivo, with respect to iron delivery.	Iron	157-161	transferrin	Homo sapiens	179-190
6421970-4	1984	At iron concentrations comparable to those of previous animal investigations, we reproduced the coagulopathy, in other words, the dose-related prolongation of the prothrombin, thrombin, and partial thromboplastin time, in human plasma in vitro.	Iron	3-7	coagulation factor II, thrombin	Homo sapiens	166-174
6421970-5	1984	Studies of the mechanism by which iron prevents a normal plasma coagulation revealed that the proenzymes of the coagulation cascade and fibrinogen were not damaged by iron.	Iron	34-38	fibrinogen beta chain	Homo sapiens	136-146
6421970-7	1984	Instead, thrombin was markedly inhibited by iron in its clotting effect on fibrinogen and, specifically, in its fibrinopeptide A-generating capacity, the inhibitory effect being reversible upon iron removal by EDTA chelation and gel filtration.	Iron	44-48	coagulation factor II, thrombin	Homo sapiens	9-17
6421970-7	1984	Instead, thrombin was markedly inhibited by iron in its clotting effect on fibrinogen and, specifically, in its fibrinopeptide A-generating capacity, the inhibitory effect being reversible upon iron removal by EDTA chelation and gel filtration.	Iron	44-48	fibrinogen beta chain	Homo sapiens	75-85
6421970-7	1984	Instead, thrombin was markedly inhibited by iron in its clotting effect on fibrinogen and, specifically, in its fibrinopeptide A-generating capacity, the inhibitory effect being reversible upon iron removal by EDTA chelation and gel filtration.	Iron	194-198	coagulation factor II, thrombin	Homo sapiens	9-17
6421970-8	1984	Thrombin generation in the presence of iron was reduced as well, indicating an inhibition of one or several other enzymes of the intrinsic coagulation cascade.	Iron	39-43	coagulation factor II, thrombin	Homo sapiens	0-8
6421970-9	1984	Because the amidolytic activity of human thrombin as well as factor Xa, kallikrein, and bovine trypsin was also reversibly suppressed by ferrous sulfate as well as ferric citrate, we consider it likely that the coagulopathy occurring in iron poisoning is the consequence of a general, physiologically important phenomenon: the susceptibility of serine proteases to nontransferrin-bound Fe3+.	Iron	237-241	coagulation factor II, thrombin	Homo sapiens	41-49
6142046-1	1984	Treatment of K562 cells with the iron chelator desferrioxamine results in the gradual increase in total cell receptors for transferrin.	Iron	33-37	transferrin	Homo sapiens	123-134
6319396-0	1984	The effect of monoclonal antibodies to the human transferrin receptor on transferrin and iron uptake by rat and rabbit reticulocytes.	Iron	89-93	transferrin	Homo sapiens	49-60
6703832-3	1984	Evidence concerning the following hypothesis is reviewed: Iron, absorbed from the intestinal tract when transferrin saturation is complete or almost so, remains unbound and is lost into the liver on first passage through the portal circulation.	Iron	58-62	transferrin	Homo sapiens	104-115
6319396-1	1984	The effect of monoclonal antibodies to the human transferrin receptor on transferrin and iron uptake by rat and rabbit reticulocytes has been examined.	Iron	89-93	transferrin	Homo sapiens	49-60
6421305-6	1984	The iron-binding capacity of plasma, an activity ascribed to plasma transferrin, was reduced in selenium-deficient and increased in selenium-supplemented animals.	Iron	4-8	transferrin	Rattus norvegicus	68-79
6706356-5	1984	This suggests that the ferrous iron concentration in media causes a reduction in growth under aerobic conditions and transferrin prevents this reduction because it decreases the ferrous iron concentration.	Iron	178-190	transferrin	Homo sapiens	117-128
6706356-6	1984	Further, serum albumin seems to be a source of iron in media.	Iron	47-51	albumin	Homo sapiens	9-22
6319515-3	1984	Transferrin receptor number decreased by more than 50% when fibroblasts from both normal and hemochromatotic subjects were maintained in iron-supplemented medium.	Iron	137-141	transferrin	Homo sapiens	0-11
6690620-4	1984	In contrast, the iron-liganding molecules transferrin and deferoxamine protected the PMN against the noxious effect of iron at concentrations just high enough to sequester all the iron.	Iron	17-21	transferrin	Homo sapiens	42-53
6690620-4	1984	In contrast, the iron-liganding molecules transferrin and deferoxamine protected the PMN against the noxious effect of iron at concentrations just high enough to sequester all the iron.	Iron	119-123	transferrin	Homo sapiens	42-53
6690620-4	1984	In contrast, the iron-liganding molecules transferrin and deferoxamine protected the PMN against the noxious effect of iron at concentrations just high enough to sequester all the iron.	Iron	119-123	transferrin	Homo sapiens	42-53
6319515-4	1984	The number of transferrin receptors expressed by normal and hemochromatotic lymphocytes after mitogen stimulation in iron-supplemented media was less than 50% that of lymphocytes which were mitogen stimulated in standard medium.	Iron	117-121	transferrin	Homo sapiens	14-25
6319515-8	1984	Although transferrin binding decreases when cells are exposed to high levels of iron in the medium, the failure to totally abolish transferrin binding to the receptor suggests that the concentration of diferric transferrin to which cells are exposed may be a major determinant of cellular iron loading in hereditary hemochromatosis.	Iron	80-84	transferrin	Homo sapiens	9-20
6701460-0	1984	Non-transferrin plasma iron in beta-thalassaemia/Hb E and haemoglobin H diseases.	Iron	23-27	transferrin	Homo sapiens	4-15
6701460-2	1984	This revealed that non-transferrin plasma iron exists in cases with severe iron overload, more striking in beta-thalassaemia/Hb E than in Hb H disease.	Iron	75-79	transferrin	Homo sapiens	23-34
6701460-3	1984	Non-transferrin plasma iron is associated with higher transferrin iron saturation and higher plasma ferritin levels.	Iron	23-27	transferrin	Homo sapiens	4-15
6701460-3	1984	Non-transferrin plasma iron is associated with higher transferrin iron saturation and higher plasma ferritin levels.	Iron	23-27	transferrin	Homo sapiens	54-65
6701460-3	1984	Non-transferrin plasma iron is associated with higher transferrin iron saturation and higher plasma ferritin levels.	Iron	66-70	transferrin	Homo sapiens	4-15
6701460-3	1984	Non-transferrin plasma iron is associated with higher transferrin iron saturation and higher plasma ferritin levels.	Iron	66-70	transferrin	Homo sapiens	54-65
6701460-4	1984	The most striking finding was the significantly higher non-transferrin plasma iron in splenectomized patients with beta-thalassaemia/Hb E disease than in the non-splenectomized patients.	Iron	78-82	transferrin	Homo sapiens	59-70
6702489-0	1984	Screening for iron overload using transferrin saturation.	Iron	14-18	transferrin	Homo sapiens	34-45
6702489-1	1984	People with parenchymal iron overload exhibit an elevated serum iron concentration and a raised transferrin (TIBC) saturation early in the course of the disease.	Iron	24-28	transferrin	Homo sapiens	96-107
6141733-3	1984	Total transferrin and iron uptake increased in a linear manner as the transferrin concentration was raised up to at least 130 microM.	Iron	22-26	transferrin	Rattus norvegicus	70-81
6141733-4	1984	This indicates that transferrin and iron are taken up primarily by nonspecific processes, possibly by endocytosis (absorptive or fluid) and by the action of iron chelators.	Iron	157-161	transferrin	Rattus norvegicus	20-31
6141733-5	1984	However, some evidence indicated the presence of receptors for diferric transferrin on hepatocytes: the molar ratio of iron to transferrin accumulation increased with incubation time, transferrin and iron uptake was proportional to the iron saturation of the transferrin, apotransferrin displaced bound apotransferrin but had no effect on the binding of diferric transferrin, and the molar ratio of iron to transferrin uptake decreased with increasing transferrin concentrations.	Iron	119-123	transferrin	Rattus norvegicus	72-83
6141733-5	1984	However, some evidence indicated the presence of receptors for diferric transferrin on hepatocytes: the molar ratio of iron to transferrin accumulation increased with incubation time, transferrin and iron uptake was proportional to the iron saturation of the transferrin, apotransferrin displaced bound apotransferrin but had no effect on the binding of diferric transferrin, and the molar ratio of iron to transferrin uptake decreased with increasing transferrin concentrations.	Iron	200-204	transferrin	Rattus norvegicus	72-83
6141733-5	1984	However, some evidence indicated the presence of receptors for diferric transferrin on hepatocytes: the molar ratio of iron to transferrin accumulation increased with incubation time, transferrin and iron uptake was proportional to the iron saturation of the transferrin, apotransferrin displaced bound apotransferrin but had no effect on the binding of diferric transferrin, and the molar ratio of iron to transferrin uptake decreased with increasing transferrin concentrations.	Iron	200-204	transferrin	Rattus norvegicus	72-83
6141733-5	1984	However, some evidence indicated the presence of receptors for diferric transferrin on hepatocytes: the molar ratio of iron to transferrin accumulation increased with incubation time, transferrin and iron uptake was proportional to the iron saturation of the transferrin, apotransferrin displaced bound apotransferrin but had no effect on the binding of diferric transferrin, and the molar ratio of iron to transferrin uptake decreased with increasing transferrin concentrations.	Iron	200-204	transferrin	Rattus norvegicus	72-83
6088313-1	1984	Transferrin receptor in hepatocytes was studied by iron-saturated[125I]transferrin binding.	Iron	51-55	transferrin	Rattus norvegicus	71-82
6326658-3	1984	The gene for TF therefore maps to the same region as the gene for transferrin receptor (TFR) thereby defining an iron transport region on 3q2 to which the transferrin-related tumor associated antigen p97 may also belong.	Iron	113-117	transferrin	Homo sapiens	13-15
6326658-3	1984	The gene for TF therefore maps to the same region as the gene for transferrin receptor (TFR) thereby defining an iron transport region on 3q2 to which the transferrin-related tumor associated antigen p97 may also belong.	Iron	113-117	transferrin	Homo sapiens	66-77
6734097-8	1984	MCH increased in all patients studied during iron therapy.	Iron	45-49	pro-melanin concentrating hormone	Homo sapiens	0-3
6088313-1	1984	Transferrin receptor in hepatocytes was studied by iron-saturated[125I]transferrin binding.	Iron	51-55	transferrin	Rattus norvegicus	0-11
6088317-2	1984	Incubation of rat reticulocytes at 37 and 4 degrees C with differic preparations of four of these transferrin forms labeled with 59Fe and 125I show no differences in membrane binding of iron and transferrin and in iron uptake.	Iron	186-190	transferrin	Rattus norvegicus	98-109
6672472-7	1983	One of the features of the proposed catalatic mechanism is the assumption, based on electron spin number, that the sixth coordination position around the hematin iron of uncomplexed catalase is unoccupied.	Iron	162-166	catalase	Homo sapiens	182-190
6325265-2	1984	It seems that two mechanisms are involved: Iron is released from endocytosed transferrin by acid vesicles.	Iron	43-47	transferrin	Rattus norvegicus	77-88
6325265-3	1984	Iron is released from surface-receptor-bound transferrin at the plasma membrane, without internalization of the transferrin receptor complex.	Iron	0-4	transferrin	Rattus norvegicus	45-56
6698286-1	1984	The mechanism by which iron is transferred from the plasma protein transferrin into erythroid precursors for incorporation in heme is not completely understood.	Iron	23-27	transferrin	Homo sapiens	67-78
6698286-5	1984	There are several indications that in reticulocytes acid vacuoles instead of lysosomes are involved in the removal of iron from endocytosed transferrin.	Iron	118-122	transferrin	Homo sapiens	140-151
6326394-0	1984	The influence of oxygen donor ligation on the spectroscopic properties of ferric cytochrome P-450: ester, ether and ketone co-ordination to the haem iron.	Iron	149-153	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-97
6326394-9	1984	The present work, in combination with our previous report of alcohol, amide and carboxylate oxygen donor complexes of cytochrome P-450, is evidence that a wide variety of oxygen-donor species are capable of direct ligation to the haem iron of cytochrome P-450.	Iron	235-239	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-134
6326394-9	1984	The present work, in combination with our previous report of alcohol, amide and carboxylate oxygen donor complexes of cytochrome P-450, is evidence that a wide variety of oxygen-donor species are capable of direct ligation to the haem iron of cytochrome P-450.	Iron	235-239	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	243-259
6372266-0	1984	Cytochrome P-450 spin state: inorganic biochemistry of haem iron ligation and functional significance.	Iron	60-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
25290935-2	1983	In this review Jeremy Brock and Tryfonia Mainou-Fowler discuss these observations in relation to transferrin"s properties as an iron-transport protein, and the relative importance of iron and transferrin in lymphocyte transformation.	Iron	128-132	transferrin	Homo sapiens	97-108
6643467-0	1983	A distinct environment for iron (III) in the complex with horse spleen apoferritin observed by x-ray absorption spectroscopy.	Iron	14-18	ferritin heavy chain	Equus caballus	71-82
6643467-1	1983	Cell-specific variations in apoferritin structure correlate with variations in iron metabolism that suggest functional specificity of the protein shell.	Iron	79-83	ferritin heavy chain	Equus caballus	28-39
6643467-6	1983	To investigate the iron-protein complex further, we have used x-ray absorption spectroscopy and have characterized, for the first time to our knowledge, Fe(III) apparently attached to the protein, after analyzing the x-ray absorption spectrum of an Fe(III)-apoferritin complex (10 Fe/molecule) compared to that of ferritin (polynuclear Fe(III)OOH, about 2000/molecule).	Iron	19-23	ferritin heavy chain	Equus caballus	257-268
6643467-9	1983	However, small differences between Fe(III)-apoferritin and Fe(III)-oxalate in the Fe-O environment suggest a distorted geometry in the Fe(III)-protein complex and/or the presence of a mixture of atoms, such as nitrogen and oxygen, coordinated to iron.	Iron	90-94	ferritin heavy chain	Equus caballus	43-54
18963494-4	1983	Some results for the concentration of manganese, iron and chromium in the River Arno are reported.	Iron	49-53	cytohesin 2	Homo sapiens	80-84
6558984-5	1983	Iron and vanadate produced small significant increases in ethane production but no increase in ALT and only minor histopathologic changes, yet potentiated lipid peroxidation and liver damage when administered with CCl4.	Iron	0-4	C-C motif chemokine ligand 4	Rattus norvegicus	214-218
6584679-3	1983	EPO was analyzed according to the mode of treatment and the degree of uremia, anemia, hypoxemia, hyperparathyroidism, and body iron load.	Iron	127-131	erythropoietin	Homo sapiens	0-3
6626742-5	1983	The major factor determining the red cell ferritin content appeared to be the transferrin saturation, that is, the distribution of iron between monoferric and diferric transferrin.	Iron	131-135	transferrin	Homo sapiens	78-89
6626742-5	1983	The major factor determining the red cell ferritin content appeared to be the transferrin saturation, that is, the distribution of iron between monoferric and diferric transferrin.	Iron	131-135	transferrin	Homo sapiens	168-179
6626742-6	1983	This is in keeping with recent data indicating a competitive advantage of diferric transferrin in delivering iron to erythroid cells.	Iron	109-113	transferrin	Homo sapiens	83-94
6873612-1	1983	The mitochondrial enzyme heme synthase (ferrochelatase) catalyzes the formation of heme from ferrous iron and protoporphyrin.	Iron	93-105	ferrochelatase	Rattus norvegicus	40-54
6678619-2	1983	Addition of transferrin has no effect on the uptake into non-viable cells but in viable cells it increases the uptake of Fe and Ga but decreases that of Pu.	Iron	121-123	transferrin	Homo sapiens	12-23
6885792-7	1983	The results demonstrate that the H2O2-dependent oxidation of phenylhydrazine by catalase and other hemoproteins results in sigma-coordination of a phenyl residue to the prosthetic heme iron.	Iron	185-189	catalase	Homo sapiens	80-88
6638491-2	1983	However, this procedure is unsatisfactory for routine purposes, since a long pretreatment of the serum with iron-donor compounds or neuraminidase is necessary in order to obtain a complete resolution of the transferrin molecule.	Iron	108-112	transferrin	Homo sapiens	207-218
6882692-5	1983	In contrast, less than 30% of the 59Fe was released, showing that iron was removed from transferrin and retained by the cells.	Iron	66-70	transferrin	Homo sapiens	88-99
6882692-7	1983	The rate of iron uptake from 59Fe and 125I labelled transferrin at 37 degrees C by the cells from different subjects was also very variable, with a range between 0.46 and 2.27 pg Fe/min/10(6) cells (n = 6).	Iron	12-16	transferrin	Homo sapiens	52-63
6882692-9	1983	This suggests that transferrin uptake and the release of iron from the transferrin to the interior of the cell are controlled independently.	Iron	57-61	transferrin	Homo sapiens	71-82
6885162-1	1983	Human serum, human transferrin (TF), and the iron chelator 1,10-phenanthroline (OP) produce iron-reversible fungistatic activity which has been attributed to simple iron deprivation.	Iron	92-96	transferrin	Homo sapiens	19-30
6309781-3	1983	At saturating concentrations of [59Fe]transferrin, and under conditions in which protein synthesis is blocked, iron uptake is linear for several hours at a rate of 9,500 transferrin molecules/cell/min.	Iron	111-115	transferrin	Homo sapiens	38-49
6885162-1	1983	Human serum, human transferrin (TF), and the iron chelator 1,10-phenanthroline (OP) produce iron-reversible fungistatic activity which has been attributed to simple iron deprivation.	Iron	92-96	transferrin	Homo sapiens	19-30
6309781-3	1983	At saturating concentrations of [59Fe]transferrin, and under conditions in which protein synthesis is blocked, iron uptake is linear for several hours at a rate of 9,500 transferrin molecules/cell/min.	Iron	111-115	transferrin	Homo sapiens	170-181
6309781-18	1983	We conclude that the low pH in endocytic vesicles is essential for the dissociation of iron from transferrin and its delivery to the cell, but is not required for recycling of transferrin, and presumably of its receptor.	Iron	87-91	transferrin	Homo sapiens	97-108
6630354-2	1983	The procedure allowed the four molecular forms of transferrin, which differ with respect to bound iron, to be separated from each other and from other plasma proteins.	Iron	98-102	transferrin	Homo sapiens	50-61
6633931-0	1983	Trophic effect of iron-bound transferrin on acetylcholine receptors in rat skeletal muscle in vivo.	Iron	18-22	transferrin	Rattus norvegicus	29-40
6308476-1	1983	Transferrin receptors are expressed in large quantities on tissues with high requirements for iron such as maturing erythroid cells and placenta.	Iron	94-98	transferrin	Homo sapiens	0-11
6633931-1	1983	Trophic effect of iron-bound transferrin (FeTf) on the total content of acetylcholine receptors (AChRs) and the specific activity of AChRs in innervated and denervated skeletal muscle was investigated in vivo.	Iron	18-22	transferrin	Rattus norvegicus	29-40
6615809-9	1983	Such a result tends to support mechanisms for iron removal from transferrin in which the ferric ion is reduced to the less tightly bound ferrous ion.	Iron	46-50	transferrin	Homo sapiens	64-75
6305999-10	1983	We propose that during cellular iron uptake, Tf receptor-ligand complexes are internalized and directed to a nonlysosomal compartment where iron is released, followed by recycling to the cell surface of an intact Tf receptor-apo-Tf complex.	Iron	32-36	transferrin	Homo sapiens	45-47
6309864-1	1983	The incorporation of iron into human cells involves the binding of diferric transferrin to a specific cell surface receptor.	Iron	21-25	transferrin	Homo sapiens	76-87
6410138-1	1983	Aluminum ion is bound to at least one of the two specific iron binding sites of serum transferrin and also to serum albumin, as shown by in vivo competition studies with 67-Ga, gel filtration chromatography and ultraviolet difference spectroscopy.	Iron	58-62	transferrin	Homo sapiens	86-97
6410138-2	1983	Binding of aluminum to transferrin requires CO2 and therefore involves a specific iron site.	Iron	82-86	transferrin	Homo sapiens	23-34
6624429-5	1983	Thus, anaemic mothers with reasonably maintained ferritin and transferrin saturation levels provide sufficient iron for maintenance of cord haemoglobin, although foetal iron stores are likely to be depleted.	Iron	111-115	transferrin	Homo sapiens	62-73
6602633-1	1983	Purified human transferrin, when saturated with iron or zinc, decreased the production of granulocyte-macrophage colony-stimulating factors (GM-CSF) by human T lymphocytes that had been stimulated by phytohemagglutin or concanavalin-A.	Iron	48-52	transferrin	Homo sapiens	15-26
6602633-2	1983	The iron-saturated transferrin was more active than the zinc-saturated transferrin.	Iron	4-8	transferrin	Homo sapiens	19-30
3836023-5	1985	Factors which influence Fe uptake have a similar effect on Ga. 239Pu uptake and binding, however, are different, especially in that Tf does not stimulate 239Pu uptake and may actually decrease it.	Iron	24-26	transferrin	Homo sapiens	132-134
6305999-10	1983	We propose that during cellular iron uptake, Tf receptor-ligand complexes are internalized and directed to a nonlysosomal compartment where iron is released, followed by recycling to the cell surface of an intact Tf receptor-apo-Tf complex.	Iron	32-36	transferrin	Homo sapiens	213-215
6305999-10	1983	We propose that during cellular iron uptake, Tf receptor-ligand complexes are internalized and directed to a nonlysosomal compartment where iron is released, followed by recycling to the cell surface of an intact Tf receptor-apo-Tf complex.	Iron	140-144	transferrin	Homo sapiens	45-47
6305716-1	1983	Hydroxyl radicals are generated in the hypoxanthine-xanthine oxidase system in the presence of iron-saturated transferrin isolated from human serum.	Iron	95-99	transferrin	Homo sapiens	110-121
6870878-0	1983	Transferrin recycling in reticulocytes: pH and iron are important determinants of ligand binding and processing.	Iron	47-51	transferrin	Rattus norvegicus	0-11
6347976-4	1983	These findings could suggest that different factors may lead to diabetes which complicates thalassaemia, i.e. insulin-resistance, probably due to liver damage subsequent to iron deposition and infectious hepatitis, and insulinopenia, probably due to beta-cell lesion following iron storage in the pancreas.	Iron	173-177	insulin	Homo sapiens	110-117
6620724-4	1983	Ca++ increased the Fe++-induced NADPH-dependent lipid peroxidation in hepatic microsomes, and this Ca++ effect was also enhanced by CCl4 treatment.	Iron	19-23	C-C motif chemokine ligand 4	Rattus norvegicus	132-136
6620724-5	1983	These results suggest that the increment of hepatic lipid peroxidation following CCl4 administration may be, at least in part, due to the increment of Fe++-induced NADPH-dependent lipid peroxidation by Ca++, and the taurine pretreatment may affect the increase by increasing Ca++ content in the liver.	Iron	151-155	C-C motif chemokine ligand 4	Rattus norvegicus	81-85
6843660-2	1983	Amino acid sequence and iron binding studies have shown that p97 is structurally and functionally related to transferrin.	Iron	24-28	transferrin	Homo sapiens	109-120
6303441-9	1983	Mitochondrial glycerol-3-phosphate dehydrogenase activity showed only small changes in iron-deficient tissues.	Iron	87-91	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	14-48
6300098-14	1983	Iron is delivered to these cells by transferrin at 37 degrees C with a rate coefficient of 0.15 to 0.2 min-1.	Iron	0-4	transferrin	Homo sapiens	36-47
6853722-6	1983	Transferrin was found in similar amounts in all regions of the small intestine, was not affected by iron loading but doubled in response to iron deficiency.	Iron	140-144	transferrin	Rattus norvegicus	0-11
6880414-3	1983	After treatment with oral iron, patients of group 1 show a significant increase in serum ferritin, serum iron, hematocrit, erythrocytes, and hemoglobin, a significant decrease in transferrin, and diminished iron absorption.	Iron	26-30	transferrin	Homo sapiens	179-190
6220972-0	1983	Role of antibody and enterobactin in controlling growth of Escherichia coli in human milk and acquisition of lactoferrin- and transferrin-bound iron by Escherichia coli.	Iron	144-148	transferrin	Homo sapiens	126-137
6220972-4	1983	When E. coli was grown in human serum trace-labeled with 59Fe, the organisms acquired iron from transferrin during growth.	Iron	86-90	transferrin	Homo sapiens	96-107
6220972-5	1983	Cultivation of E. coli in a minimal medium supplemented with transferrin or lactoferrin doubly labeled with 125I and 59Fe showed that iron acquisition occurred without either assimilation or degradation of the iron-binding proteins.	Iron	134-138	transferrin	Homo sapiens	61-72
6131699-6	1983	Instead they show that the major effect of the bases is to inhibit iron release from transferrin molecules on or within the cells.	Iron	67-71	transferrin	Rattus norvegicus	85-96
6131699-9	1983	It is concluded that the bases tested in this work inhibit iron release from transferrin in intracellular vesicles by increasing their pH rather than by blocking transglutaminase and thereby restricting endocytosis.	Iron	59-63	transferrin	Rattus norvegicus	77-88
6300098-15	1983	The iron is released from the transferrin and the majority is found in intracellular ferritin.	Iron	4-8	transferrin	Homo sapiens	30-41
6884561-2	1983	In this study iron dynamics are investigated by determining concentrations of hemoglobin, serum ferritin and serum transferrin in two groups of pregnant women.	Iron	14-18	transferrin	Homo sapiens	115-126
6573263-2	1983	Our results show that iron-carrying transferrin became bound to specific dimeric cell surface receptors.	Iron	22-26	transferrin	Homo sapiens	36-47
6573263-5	1983	This suggests that the acid pH in endosomes leads to the cleavage of the iron-transferrin bonds.	Iron	73-77	transferrin	Homo sapiens	78-89
6402233-4	1983	That this reflected persistent iron overload with inadequate phlebotomy was suggested by the higher serum iron concentrations, percentage transferrin saturation, and urinary excretion of iron after administration of desferrioxamine, together with a lower annual iron loss by phlebotomy in this group compared with patients with treated disease and normal red cell ferritin content.	Iron	31-35	transferrin	Homo sapiens	138-149
6300904-4	1983	Using the values of these binding parameters, we propose a mechanism to account for the recycling of transferrin subsequent to internalization and residence within an acidic nonlysosomal organelle where iron is removed.	Iron	203-207	transferrin	Homo sapiens	101-112
6833213-7	1983	Transferrin consists of two homologous domains (residues 1-336, 337-679), each associated with a single Fe-binding site, with both sites of glycosylation in the carboxyl-terminal domain at positions 413 and 611.	Iron	104-106	transferrin	Homo sapiens	0-11
6347280-1	1983	Lactotransferrin is involved in the antibacterial defence of the host by virtue of its reversible iron-binding capacity.	Iron	98-102	lactotransferrin	Homo sapiens	0-16
6133718-1	1983	Cimetidine (I) interacts with the hemin iron of cytochrome P-450 from rat liver microsomes, with its imidazole and cyano coordinating groups.	Iron	40-44	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-64
6297814-4	1983	In the case of iron, its intracellular concentration must be higher to give the enzyme inactivation exerted by CCl4.	Iron	15-19	C-C motif chemokine ligand 4	Rattus norvegicus	111-115
6827563-2	1983	Synthesis and kinetics of iron removal from transferrin of catechoyl derivatives of desferrioxamine B.	Iron	26-30	transferrin	Homo sapiens	44-55
6832286-2	1983	For the first time the possibility of a 6-fold internal homology of the transferrins is raised: a scheme in which 6 domains are defined is reported; two of them with the highest homology seem to be implicated in the 2 iron binding sites of each transferrin.	Iron	218-222	transferrin	Homo sapiens	72-83
6406696-4	1983	In in virto experiments, 74% of this iron was available to transferrin.	Iron	37-41	transferrin	Homo sapiens	59-70
6600790-2	1983	Troleandomycin, a macrolide antibiotic, has been shown to be demethylated and oxidized into a metabolite which forms an inactive complex with the iron(II) of cytochrome P-450.	Iron	146-150	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	158-174
6296151-7	1983	These findings indicate an identical peptide structure of the human transferrin receptor in cells with a differentiated function for iron metabolism, in normal cells undergoing mitosis, and in neoplastic cells in long term culture, within the limits of detectability of the proteolytic digestion maps.	Iron	133-137	transferrin	Homo sapiens	68-79
6635261-0	1983	[Binding of 67 Ga and 59 Fe to ferritin or transferrin].	Iron	25-27	transferrin	Homo sapiens	43-54
6185486-10	1983	Although iron bleomycin does not have a polyaromatic structure like heme, many features of its electronic structure at the iron are very similar to those produced by the sulfur-coordinated heme iron of ferric cytochrome P-450, a protein that catalyzes a similar oxygen-dependent reaction.	Iron	9-13	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	209-225
6185486-10	1983	Although iron bleomycin does not have a polyaromatic structure like heme, many features of its electronic structure at the iron are very similar to those produced by the sulfur-coordinated heme iron of ferric cytochrome P-450, a protein that catalyzes a similar oxygen-dependent reaction.	Iron	123-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	209-225
6821698-0	1983	The significance of transferrin for intestinal iron absorption.	Iron	47-51	transferrin	Rattus norvegicus	20-31
6824083-0	1983	Effect of iron stores on hepatic metabolism of transferrin-bound iron.	Iron	10-14	transferrin	Rattus norvegicus	47-58
6824083-0	1983	Effect of iron stores on hepatic metabolism of transferrin-bound iron.	Iron	65-69	transferrin	Rattus norvegicus	47-58
6821698-2	1983	Within the cell, iron is released and transferred to the blood stream, whereas iron-free transferrin returns to the brush border to be recycled.	Iron	79-83	transferrin	Rattus norvegicus	89-100
6821698-6	1983	In normal animals, 4 micrograms of the 50 micrograms of transferrin iron was absorbed over 1 hr.	Iron	68-72	transferrin	Rattus norvegicus	56-67
6821698-13	1983	These studies support the role of mucosal transferrin as a shuttle protein for iron absorption.	Iron	79-83	transferrin	Rattus norvegicus	42-53
6296164-1	1983	Iron-loaded transferrin has been shown to be necessary for the support of cell proliferation in culture.	Iron	0-4	transferrin	Rattus norvegicus	12-23
6301443-2	1983	At low Fe2+, leukotriene inactivation was inhibited by catalase, superoxide dismutase, mannitol and ethanol, suggesting involvement of hydroxyl radicals generated by the iron-catalyzed interaction of superoxide and H2O2 (Haber-Weiss reaction).	Iron	170-174	catalase	Homo sapiens	55-63
6402006-2	1983	It is well established that Ga3+ travels through the circulatory system bound to the serum iron transport protein transferrin and that this protein binding is an essential step in tumor localization.	Iron	91-95	transferrin	Homo sapiens	114-125
6826774-7	1983	A deficient iron intake accounted for the high incidence of low haemoglobin in the Indian group in whom low transferrin saturation and serum ferritin were observed.	Iron	12-16	transferrin	Homo sapiens	108-119
6679475-2	1983	Intracellular transferrin was able to donate iron to the small-molecular weight iron pool, and the latter was able to transfer, by a process not requiring energy or movement of serum transferrin, iron to ferritin.	Iron	45-49	transferrin	Rattus norvegicus	14-25
6299195-3	1983	An analysis of the dependence of the proton relaxation rate on the observation frequency indicated that the correlation time, which modulates the interaction between solvent protons and the unpaired electrons on the metal ions, is due to the electron spin relaxation time of the heme irons of cytochrome c oxidase.	Iron	284-289	cytochrome c, somatic	Homo sapiens	293-305
6318930-0	1983	[Modulation of the expression of transferrin receptors by iron, hemin and protoporphyrin IX].	Iron	58-62	transferrin	Homo sapiens	33-44
6848512-5	1983	The prosthetic heme in the inactivated cytochrome P-450 enzyme, therefore, has exactly the same orientation, relative to the fifth iron ligand, as the heme in hemoglobin.	Iron	131-135	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-55
6675690-1	1983	Electron microscope autoradiography was used to quantitate the uptake of transferrin and transferrin-bound iron by rat erythroid cells at the various stages of development.	Iron	107-111	transferrin	Rattus norvegicus	89-100
6675690-2	1983	The capacity of the cells to take up iron closely paralleled their ability to bind transferrin, suggesting that the level of transferrin receptors is the major factor which regulates the rate at which immature erythroid cells can accumulate iron.	Iron	37-41	transferrin	Rattus norvegicus	125-136
6675690-2	1983	The capacity of the cells to take up iron closely paralleled their ability to bind transferrin, suggesting that the level of transferrin receptors is the major factor which regulates the rate at which immature erythroid cells can accumulate iron.	Iron	241-245	transferrin	Rattus norvegicus	83-94
6675690-2	1983	The capacity of the cells to take up iron closely paralleled their ability to bind transferrin, suggesting that the level of transferrin receptors is the major factor which regulates the rate at which immature erythroid cells can accumulate iron.	Iron	241-245	transferrin	Rattus norvegicus	125-136
6675690-4	1983	During development, immature rat erythroid cells acquire about twice as much iron from transferrin as is present in the haemoglobin of mature erythrocytes.	Iron	77-81	transferrin	Rattus norvegicus	87-98
6193867-4	1983	If ADM-induced PEC were treated with carbonyl iron prior to coculture with spleen cells, augmentation of anti-YAC-1 activity was not observed.	Iron	46-50	ADP-ribosyltransferase 1	Mus musculus	110-115
6094079-2	1983	Such iron transfer from serotransferrin (TF) to hepatocytes involves a TF receptor.	Iron	5-9	transferrin	Rattus norvegicus	24-39
6679475-2	1983	Intracellular transferrin was able to donate iron to the small-molecular weight iron pool, and the latter was able to transfer, by a process not requiring energy or movement of serum transferrin, iron to ferritin.	Iron	80-84	transferrin	Rattus norvegicus	14-25
6679475-2	1983	Intracellular transferrin was able to donate iron to the small-molecular weight iron pool, and the latter was able to transfer, by a process not requiring energy or movement of serum transferrin, iron to ferritin.	Iron	80-84	transferrin	Rattus norvegicus	14-25
6679475-5	1983	It is concluded that iron is taken up by the rat hepatocyte from serum transferrin by a process not requiring energy or movement of serum transferrin into the cell interior; and that intracellular transferrin is involved in acquiring iron from serum transferrin at the cell surface, with iron then being transferred to the small-molecular weight iron pool and hence to ferritin.	Iron	21-25	transferrin	Rattus norvegicus	71-82
6315573-2	1983	Human transferrin, when saturated with iron (FeTf), was found to inhibit human natural killer (NK) activity against K562 tumor cells, if included in assay mixtures at physiologically relevant levels.	Iron	39-43	transferrin	Homo sapiens	6-17
6575912-1	1983	While evaluating the role of iron-binding glycoproteins on the in vitro uptake of 67Ga and 59Fe by tumor cells, it was observed that these radiometals bind to polystyrene culture tubes in the presence of transferrin or lactoferrin.	Iron	29-33	transferrin	Homo sapiens	204-215
6315573-3	1983	Whereas both FeTf and iron-free transferrin (ApoTf) inhibited initial conjugate formation at the level of the target cell, only FeTf inhibited NK cytolytic activity, as judged by release of chromium from the targets.	Iron	22-26	transferrin	Homo sapiens	32-43
7170173-0	1982	[Non-transferrin-bound iron in 4 patients with excessive amounts of iron in the blood].	Iron	23-27	transferrin	Homo sapiens	5-16
6633760-4	1983	In contrast, transferrin saturation could only be used for indicating iron overload.	Iron	70-74	transferrin	Homo sapiens	13-24
6572005-0	1983	Competitive advantage of diferric transferrin in delivering iron to reticulocytes.	Iron	60-64	transferrin	Homo sapiens	34-45
6572005-2	1983	In mixtures of human diferric and monoferric transferrin, the diferric molecule had a constant 7-fold advantage in delivering iron to reticulocytes, as compared with the 2-fold advantage when single solutions of mono- and diferric transferrins were compared.	Iron	126-130	transferrin	Homo sapiens	45-56
6572005-3	1983	This was shown to be due to competitive interaction in iron delivery, probably at a common membrane-receptor binding site for transferrin.	Iron	55-59	transferrin	Homo sapiens	126-137
7160481-3	1982	At 37 degrees C, iron uptake is much more important than transferrin uptake; it proceeds linearly over the time of incubation, is largely proportional to the extracellular transferrin concentration, and is compatible with uptake by fluid phase endocytosis.	Iron	17-21	transferrin	Rattus norvegicus	172-183
7160481-4	1982	The difference observed between iron and transferrin uptake implies the existence of a mechanism allowing the reutilization of transferrin after iron delivery.	Iron	32-36	transferrin	Rattus norvegicus	127-138
7160481-4	1982	The difference observed between iron and transferrin uptake implies the existence of a mechanism allowing the reutilization of transferrin after iron delivery.	Iron	145-149	transferrin	Rattus norvegicus	41-52
7160481-4	1982	The difference observed between iron and transferrin uptake implies the existence of a mechanism allowing the reutilization of transferrin after iron delivery.	Iron	145-149	transferrin	Rattus norvegicus	127-138
6381341-1	1983	In rats, troleandomycin induces microsomal enzymes and promotes its own transformation into a metabolite forming an inactive complex with the iron (II) of cytochrome P-450; eventually, several monooxygenase activities are markedly reduced.	Iron	142-146	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	155-171
6572903-8	1983	Immunoprecipitation studies performed on cells that had been incubated with 59Fe-containing transferrin indicated that chromosome 19-containing cells incorporated iron into intact and functional molecules of human ferritin.	Iron	163-167	transferrin	Homo sapiens	92-103
7170173-0	1982	[Non-transferrin-bound iron in 4 patients with excessive amounts of iron in the blood].	Iron	68-72	transferrin	Homo sapiens	5-16
7188434-5	1982	In all cell types iron uptake is related to transferrin saturation.	Iron	18-22	transferrin	Homo sapiens	44-55
7138791-4	1982	Macrophages are also capable of binding about one-third as much iron-saturated transferrin as iron-free transferrin.	Iron	64-68	transferrin	Rattus norvegicus	79-90
7138791-4	1982	Macrophages are also capable of binding about one-third as much iron-saturated transferrin as iron-free transferrin.	Iron	94-98	transferrin	Rattus norvegicus	104-115
6818832-8	1982	This demonstrates that these lactotransferrins ingested by babies are not completely destroyed and keep their ability to bind iron, and thus may supplement the bacteriostatic effects of the endogenous lactotransferrin in the intestinal tract.	Iron	126-130	lactotransferrin	Homo sapiens	29-45
7175808-3	1982	These results suggest that the increase in iron transfer to the fetus occurs as a result of an increase in the number of transferrin receptors on the maternal surface of the placenta rather than being due to a change in the affinity or turnover rate of the existing receptors, although disproportionate change in the number of receptors and maternal placental surface area suggests that there may be a reduction of the density of transferrin receptors.	Iron	43-47	transferrin	Rattus norvegicus	121-132
7175808-3	1982	These results suggest that the increase in iron transfer to the fetus occurs as a result of an increase in the number of transferrin receptors on the maternal surface of the placenta rather than being due to a change in the affinity or turnover rate of the existing receptors, although disproportionate change in the number of receptors and maternal placental surface area suggests that there may be a reduction of the density of transferrin receptors.	Iron	43-47	transferrin	Rattus norvegicus	430-441
7175808-4	1982	The ratios of fetal and total (fetal plus placental) iron to transferrin showed that maturation of the mechanism of iron release from transferrin and the intra-placental iron transport system occurred during development.	Iron	116-120	transferrin	Rattus norvegicus	61-72
7175808-4	1982	The ratios of fetal and total (fetal plus placental) iron to transferrin showed that maturation of the mechanism of iron release from transferrin and the intra-placental iron transport system occurred during development.	Iron	116-120	transferrin	Rattus norvegicus	134-145
7175808-4	1982	The ratios of fetal and total (fetal plus placental) iron to transferrin showed that maturation of the mechanism of iron release from transferrin and the intra-placental iron transport system occurred during development.	Iron	116-120	transferrin	Rattus norvegicus	61-72
7175808-4	1982	The ratios of fetal and total (fetal plus placental) iron to transferrin showed that maturation of the mechanism of iron release from transferrin and the intra-placental iron transport system occurred during development.	Iron	116-120	transferrin	Rattus norvegicus	134-145
6297460-11	1982	These results suggest that fibroblast transferrin receptor number is modulated by intracellular iron content and not by ligand-receptor binding.	Iron	96-100	transferrin	Homo sapiens	38-49
6818722-4	1982	Although other forms of iron found physiologically might cause considerable oxidative damage through mechanisms similar to that of Fe-EDTA, our studies indicate considerable mitigation of such toxicity in ferritin and transferrin, which constitute major forms of transport and storage of iron in vivo.	Iron	24-28	transferrin	Homo sapiens	218-229
6818722-4	1982	Although other forms of iron found physiologically might cause considerable oxidative damage through mechanisms similar to that of Fe-EDTA, our studies indicate considerable mitigation of such toxicity in ferritin and transferrin, which constitute major forms of transport and storage of iron in vivo.	Iron	288-292	transferrin	Homo sapiens	218-229
6816292-0	1982	The effect of pH on the kinetics of iron release from human transferrin.	Iron	36-40	transferrin	Homo sapiens	60-71
7107639-2	1982	Extended x-ray absorption fine structure spectroscopy has been applied to the elucidation of the structure of the heme iron site of bacterial cytochrome P-450.	Iron	119-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	142-158
7126464-5	1982	Transferrin 59Fe was distinguished by a greater reflux to the erythron in iron deficient rats, and by excretion of a larger proportion of 59Fe chelated by DF in the urine.	Iron	74-78	transferrin	Rattus norvegicus	0-11
6750065-2	1982	One of the serum bacteriostatic components is transferrin, the major iron-binding protein.	Iron	69-73	transferrin	Homo sapiens	46-57
6750065-3	1982	In the presence of transferrin, free iron, which is required for bacterial nucleoprotein synthesis, is unavailable and bacterial growth is inhibited.	Iron	37-41	transferrin	Homo sapiens	19-30
6750065-4	1982	In an in vitro system, we tested the hypothesis that serum with highly saturated transferrin allows free iron to be available for rapid bacterial growth.	Iron	105-109	transferrin	Homo sapiens	81-92
6750065-5	1982	We first confirmed the finding that addition of ionic iron sufficient to saturate transferrin in normal sera inhibits the bacteriostatic activity for Escherichia coli.	Iron	54-58	transferrin	Homo sapiens	82-93
6750065-7	1982	This finding supports the thesis that iron added in vitro is more easily extracted than in vivo, where it is tightly bound to transferrin, and does not support the contention that ordinary iron treatment predisposes infants to infection.	Iron	38-42	transferrin	Homo sapiens	126-137
6816235-0	1982	On the spin and valence state of iron in native soybean lipoxygenase-1.	Iron	33-37	seed linoleate 13S-lipoxygenase-1	Glycine max	56-70
6816218-0	1982	The preparation and partial characterization of N-terminal and C-terminal iron-binding fragments from rabbit serum transferrin.	Iron	74-78	transferrin	Homo sapiens	115-126
7138904-0	1982	Evidence for the functional equivalence of the iron-binding sites of rat transferrin.	Iron	47-51	transferrin	Rattus norvegicus	73-84
7138904-1	1982	The role of the two iron-binding sites of rat transferrin in the exchange of iron with cells has been assessed using urea polyacrylamide gel electrophoresis to separate and quantitate the four possible molecular species of transferrin generated during the incubation of 125I-labelled transferrin with rat reticulocytes and hepatocytes.	Iron	20-24	transferrin	Rattus norvegicus	46-57
7138904-1	1982	The role of the two iron-binding sites of rat transferrin in the exchange of iron with cells has been assessed using urea polyacrylamide gel electrophoresis to separate and quantitate the four possible molecular species of transferrin generated during the incubation of 125I-labelled transferrin with rat reticulocytes and hepatocytes.	Iron	20-24	transferrin	Rattus norvegicus	223-234
7138904-1	1982	The role of the two iron-binding sites of rat transferrin in the exchange of iron with cells has been assessed using urea polyacrylamide gel electrophoresis to separate and quantitate the four possible molecular species of transferrin generated during the incubation of 125I-labelled transferrin with rat reticulocytes and hepatocytes.	Iron	20-24	transferrin	Rattus norvegicus	223-234
7138904-1	1982	The role of the two iron-binding sites of rat transferrin in the exchange of iron with cells has been assessed using urea polyacrylamide gel electrophoresis to separate and quantitate the four possible molecular species of transferrin generated during the incubation of 125I-labelled transferrin with rat reticulocytes and hepatocytes.	Iron	77-81	transferrin	Rattus norvegicus	46-57
7138904-3	1982	After 2 h 44.8% of the iron had been removed by the cells, and of the iron-depleted transferrin 71.8% was apotransferrin, the remainder being monoferric transferrin, 16.1% with N-terminal iron and 12.1% with C-terminal iron.	Iron	70-74	transferrin	Rattus norvegicus	84-95
7138904-3	1982	After 2 h 44.8% of the iron had been removed by the cells, and of the iron-depleted transferrin 71.8% was apotransferrin, the remainder being monoferric transferrin, 16.1% with N-terminal iron and 12.1% with C-terminal iron.	Iron	70-74	transferrin	Rattus norvegicus	109-120
7138904-3	1982	After 2 h 44.8% of the iron had been removed by the cells, and of the iron-depleted transferrin 71.8% was apotransferrin, the remainder being monoferric transferrin, 16.1% with N-terminal iron and 12.1% with C-terminal iron.	Iron	70-74	transferrin	Rattus norvegicus	84-95
7138904-3	1982	After 2 h 44.8% of the iron had been removed by the cells, and of the iron-depleted transferrin 71.8% was apotransferrin, the remainder being monoferric transferrin, 16.1% with N-terminal iron and 12.1% with C-terminal iron.	Iron	70-74	transferrin	Rattus norvegicus	109-120
7138904-3	1982	After 2 h 44.8% of the iron had been removed by the cells, and of the iron-depleted transferrin 71.8% was apotransferrin, the remainder being monoferric transferrin, 16.1% with N-terminal iron and 12.1% with C-terminal iron.	Iron	70-74	transferrin	Rattus norvegicus	84-95
7138904-3	1982	After 2 h 44.8% of the iron had been removed by the cells, and of the iron-depleted transferrin 71.8% was apotransferrin, the remainder being monoferric transferrin, 16.1% with N-terminal iron and 12.1% with C-terminal iron.	Iron	70-74	transferrin	Rattus norvegicus	109-120
7138904-7	1982	Release of iron from hepatocytes to apotransferrin lead to the appearance of both monoferric species and then to increasing amounts of diferric transferrin.	Iron	11-15	transferrin	Rattus norvegicus	39-50
6127735-4	1982	The function of cytochrome c3 (Mr = 13000) in the mechanism of the periplasmic hydrogenase and the role of the new [3Fe-3S] non-haem iron centres in electron transfer is emphasized.	Iron	133-137	cytochrome c, somatic	Homo sapiens	16-28
6286649-9	1982	Cells grown in media supplemented with diferric transferrin or ferric ammonium citrate exhibited an increase in cytosolic iron content.	Iron	122-126	transferrin	Homo sapiens	48-59
6816218-1	1982	Two iron-binding fragments of Mr 36 000 and 33 000 corresponding to the N-terminal domain of rabbit serum transferrin were prepared.	Iron	4-8	transferrin	Homo sapiens	106-117
6891410-0	1982	Relationship of serum transferrin to total iron binding capacity for nutritional assessment.	Iron	43-47	transferrin	Homo sapiens	22-33
7085638-2	1982	Transferrin, the serum iron transport protein, provides an excellent model for studying biological metal ion exchange reactions.	Iron	23-27	transferrin	Homo sapiens	0-11
6289365-0	1982	Resolved fluorescence emission spectra of iron-free cytochrome c.	Iron	42-46	cytochrome c, somatic	Homo sapiens	52-64
6288087-1	1982	In 5,5"-dithiobis(2-nitrobenzoate) (DTNB)-treated succinate: cytochrome c reductase, the electron transfer from duroquinol to cytochrome c is inhibited due to the fact that the Rieske Fe-S cluster and, consequently, cytochrome, c, are no longer reducible by substrate.	Iron	184-188	cytochrome c, somatic	Homo sapiens	61-73
6288087-1	1982	In 5,5"-dithiobis(2-nitrobenzoate) (DTNB)-treated succinate: cytochrome c reductase, the electron transfer from duroquinol to cytochrome c is inhibited due to the fact that the Rieske Fe-S cluster and, consequently, cytochrome, c, are no longer reducible by substrate.	Iron	184-188	cytochrome c, somatic	Homo sapiens	126-138
7137164-7	1982	The process of hemoglobin-iron release to extracellular transferrin was inhibited at 4 degrees C but was unaffected by inhibitory of protein synthesis, glycolysis, microtubule function, and microfilament function.	Iron	26-30	transferrin	Homo sapiens	56-67
6282850-0	1982	Iron binding by horse spleen apoferritin.	Iron	0-4	ferritin heavy chain	Equus caballus	29-40
6284217-1	1982	(1) Using the pulse-radiolysis and stopped-flow techniques, the reactions of iron-free (porphyrin) cytochrome c and native cytochrome c with cytochrome aa3 were investigated.	Iron	77-81	cytochrome c, somatic	Homo sapiens	99-111
6281261-3	1982	An analogue of cytochrome c in which the iron atom was replaced with cobalt was used to probe the effect of redox potential on the reaction.	Iron	41-45	cytochrome c, somatic	Homo sapiens	15-27
7084326-0	1982	Role of iron in transferrin-dependent lymphocyte mitogenesis in serum-free medium.	Iron	8-12	transferrin	Homo sapiens	16-27
7059591-1	1982	The kinetics of the cellular uptake of iron-transferrin complex was studied in L1210 murine leukemia cells and rat reticulocytes using 125I-transferrin.	Iron	39-43	transferrin	Rattus norvegicus	140-151
7085894-4	1982	Pinocytosis of iron dextran by the trophoblast and increased transport of transferrin-bound iron to the placenta are considered as possible causes for this large uptake of iron by the placenta.	Iron	92-96	transferrin	Homo sapiens	74-85
6277946-5	1982	As increasing amounts of iron-sulfur protein are reconstituted to the depleted complex, the amounts of cytochromes b and c1 reduced by succinate in the presence of antimycin increase and closely parallel the amounts of ubiquinol-cytochrome c reductase activity restored to the reconstituted complex, measured before addition of antimycin.	Iron	25-29	cytochrome c, somatic	Homo sapiens	229-241
6804495-5	1982	Since additional studies indicate that proliferating cells have increased iron uptake, a simple hypothesis would predict that the parallel increase in transferrin binding sites and total cellular immunoreactive receptor associated with proliferation is related to an increased cellular iron requirement.	Iron	74-78	transferrin	Homo sapiens	151-162
6804495-5	1982	Since additional studies indicate that proliferating cells have increased iron uptake, a simple hypothesis would predict that the parallel increase in transferrin binding sites and total cellular immunoreactive receptor associated with proliferation is related to an increased cellular iron requirement.	Iron	286-290	transferrin	Homo sapiens	151-162
6953407-6	1982	Transferrin--which contains two Fe-binding sites--has clearly evolved by the contiguous duplication of the structural gene for an ancestral protein that had a single Fe-binding site and contained approximately 340 amino acid residues.	Iron	32-34	transferrin	Homo sapiens	0-11
6953407-6	1982	Transferrin--which contains two Fe-binding sites--has clearly evolved by the contiguous duplication of the structural gene for an ancestral protein that had a single Fe-binding site and contained approximately 340 amino acid residues.	Iron	166-168	transferrin	Homo sapiens	0-11
7092809-0	1982	The effect of salt concentration on the iron-binding properties of human transferrin.	Iron	40-44	transferrin	Homo sapiens	73-84
7092809-1	1982	The salt dependence of the iron-binding properties of transferrin was studied by urea/polyacrylamide-gel electrophoresis.	Iron	27-31	transferrin	Homo sapiens	54-65
6805985-0	1982	Influence of iron saturation as a possible source of error in the immunoturbidimetric determination of serum transferrin.	Iron	13-17	transferrin	Homo sapiens	109-120
6210635-0	1982	Expression of a high-affinity mechanism for acquisition of transferrin iron by Neisseria meningitidis.	Iron	71-75	transferrin	Homo sapiens	59-70
6210635-1	1982	Iron-starved meningococci grown at either pH 7.2 or 6.6 were capable of removing and incorporating iron from human transferrin by a saturable, cell surface mechanism that specifically recognized transferrin rather than iron.	Iron	0-4	transferrin	Homo sapiens	115-126
6210635-1	1982	Iron-starved meningococci grown at either pH 7.2 or 6.6 were capable of removing and incorporating iron from human transferrin by a saturable, cell surface mechanism that specifically recognized transferrin rather than iron.	Iron	0-4	transferrin	Homo sapiens	195-206
6210635-1	1982	Iron-starved meningococci grown at either pH 7.2 or 6.6 were capable of removing and incorporating iron from human transferrin by a saturable, cell surface mechanism that specifically recognized transferrin rather than iron.	Iron	99-103	transferrin	Homo sapiens	115-126
6210635-1	1982	Iron-starved meningococci grown at either pH 7.2 or 6.6 were capable of removing and incorporating iron from human transferrin by a saturable, cell surface mechanism that specifically recognized transferrin rather than iron.	Iron	99-103	transferrin	Homo sapiens	195-206
7039871-4	1982	The results showed that caeruloplasmin, transferrin and albumin are the major proteins that bind copper, iron and zinc, respectively.	Iron	105-109	transferrin	Homo sapiens	40-51
6277374-7	1982	In this paper, we discuss the possible methods of analysis of such data and present the results of our model refinement analysis concerning (a) the location of the cytochrome c heme iron atom in the profile structure of a reconstituted membrane containing a photosynthetic reaction center-cytochrome c complex and (b) the location of the heme a and a3 iron atoms in the profile structure of a reconstituted membrane containing cytochrome oxidase.	Iron	182-186	cytochrome c, somatic	Homo sapiens	164-176
6277374-7	1982	In this paper, we discuss the possible methods of analysis of such data and present the results of our model refinement analysis concerning (a) the location of the cytochrome c heme iron atom in the profile structure of a reconstituted membrane containing a photosynthetic reaction center-cytochrome c complex and (b) the location of the heme a and a3 iron atoms in the profile structure of a reconstituted membrane containing cytochrome oxidase.	Iron	182-186	cytochrome c, somatic	Homo sapiens	289-301
6277374-7	1982	In this paper, we discuss the possible methods of analysis of such data and present the results of our model refinement analysis concerning (a) the location of the cytochrome c heme iron atom in the profile structure of a reconstituted membrane containing a photosynthetic reaction center-cytochrome c complex and (b) the location of the heme a and a3 iron atoms in the profile structure of a reconstituted membrane containing cytochrome oxidase.	Iron	352-356	cytochrome c, somatic	Homo sapiens	164-176
7068574-7	1982	From these changes and also changes in CD spectra, we deduced that fluoride, chloride, and bromide ions can bind with heme iron of the catalase molecule as ligands to form stable catalase-halide complexes, but iodide ions showed a different reactivity with catalase from other halides and may cause gross alteration in the structure or conformation of catalase.	Iron	123-127	catalase	Homo sapiens	179-187
6802544-3	1982	There were significant correlation between iron absorption and plasma transferrin (r = 0.56, P less then 0.001); and between log iron absorption and log serum ferritin (r = 0.80, P less than 0.01) in peritoneal dialysis patients.	Iron	43-47	transferrin	Homo sapiens	70-81
7068574-7	1982	From these changes and also changes in CD spectra, we deduced that fluoride, chloride, and bromide ions can bind with heme iron of the catalase molecule as ligands to form stable catalase-halide complexes, but iodide ions showed a different reactivity with catalase from other halides and may cause gross alteration in the structure or conformation of catalase.	Iron	123-127	catalase	Homo sapiens	135-143
7068574-7	1982	From these changes and also changes in CD spectra, we deduced that fluoride, chloride, and bromide ions can bind with heme iron of the catalase molecule as ligands to form stable catalase-halide complexes, but iodide ions showed a different reactivity with catalase from other halides and may cause gross alteration in the structure or conformation of catalase.	Iron	123-127	catalase	Homo sapiens	179-187
7055644-7	1982	Indeed, a higher plasma iron and transferrin saturation augmented the movement of iron into the plasma from iron-donating tissues.	Iron	82-86	transferrin	Rattus norvegicus	33-44
7055644-7	1982	Indeed, a higher plasma iron and transferrin saturation augmented the movement of iron into the plasma from iron-donating tissues.	Iron	82-86	transferrin	Rattus norvegicus	33-44
7055644-8	1982	It is proposed that the donation of iron by transferrin in some way immediately facilitates the procurement of more iron by transferrin.	Iron	36-40	transferrin	Rattus norvegicus	44-55
7055644-8	1982	It is proposed that the donation of iron by transferrin in some way immediately facilitates the procurement of more iron by transferrin.	Iron	36-40	transferrin	Rattus norvegicus	124-135
7055644-8	1982	It is proposed that the donation of iron by transferrin in some way immediately facilitates the procurement of more iron by transferrin.	Iron	116-120	transferrin	Rattus norvegicus	44-55
7055644-8	1982	It is proposed that the donation of iron by transferrin in some way immediately facilitates the procurement of more iron by transferrin.	Iron	116-120	transferrin	Rattus norvegicus	124-135
7055660-4	1982	Given IV, 125-I-human transferrin was not preferentially bound in tumour whereas in muscle tissue loaded with transferrin, 67Ga was accumulated locally during the immediate post-injection phase and to an enhanced degree in iron-treated animals.	Iron	223-227	transferrin	Homo sapiens	110-121
7068574-7	1982	From these changes and also changes in CD spectra, we deduced that fluoride, chloride, and bromide ions can bind with heme iron of the catalase molecule as ligands to form stable catalase-halide complexes, but iodide ions showed a different reactivity with catalase from other halides and may cause gross alteration in the structure or conformation of catalase.	Iron	123-127	catalase	Homo sapiens	179-187
6280171-6	1982	This result suggests that either transferrin is the only means by which CCRF-CEM leukemic cells can be provided with sufficient iron in vitro or that other factors in addition to iron starvation are involved in the antibody-mediated growth inhibition.	Iron	128-132	transferrin	Homo sapiens	33-44
6121647-0	1982	Comparative aspects of transferrin-reticulocyte interactions: membrane receptors and iron uptake.	Iron	85-89	transferrin	Homo sapiens	23-34
6803786-0	1982	Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water.	Iron	61-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47
7082283-2	1982	The variant transferrin is able to bind two atoms of iron, but the iron in the C-terminal binding site is bound abnormally, as judged by its spectral properties, and is dissociated from the protein on electrophoresis in the presence of 6 M-urea.	Iron	53-57	transferrin	Homo sapiens	12-23
7082283-2	1982	The variant transferrin is able to bind two atoms of iron, but the iron in the C-terminal binding site is bound abnormally, as judged by its spectral properties, and is dissociated from the protein on electrophoresis in the presence of 6 M-urea.	Iron	67-71	transferrin	Homo sapiens	12-23
7094429-10	1982	The inhibitory action of metabolic inhibitors on iron uptake by reticulocytes was accompanied by an accumulation of transferrin and ion in the stroma suggesting that a block in the iron release from transferrin occurs at the stroma level.	Iron	49-53	transferrin	Homo sapiens	116-127
7094429-10	1982	The inhibitory action of metabolic inhibitors on iron uptake by reticulocytes was accompanied by an accumulation of transferrin and ion in the stroma suggesting that a block in the iron release from transferrin occurs at the stroma level.	Iron	49-53	transferrin	Homo sapiens	199-210
7094429-10	1982	The inhibitory action of metabolic inhibitors on iron uptake by reticulocytes was accompanied by an accumulation of transferrin and ion in the stroma suggesting that a block in the iron release from transferrin occurs at the stroma level.	Iron	181-185	transferrin	Homo sapiens	199-210
7123065-0	1982	[Determination of serum iron and transport capacity of iron by transferrin].	Iron	24-28	transferrin	Homo sapiens	63-74
7123065-0	1982	[Determination of serum iron and transport capacity of iron by transferrin].	Iron	55-59	transferrin	Homo sapiens	63-74
7171721-2	1982	In contrast to the equilibrium form of ferrous cytochrome P-450 with the heme iron in the high-spin state the non-equilibrium ferrous state has a low-spin heme iron.	Iron	78-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	47-63
7171721-2	1982	In contrast to the equilibrium form of ferrous cytochrome P-450 with the heme iron in the high-spin state the non-equilibrium ferrous state has a low-spin heme iron.	Iron	160-164	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	47-63
6121647-7	1982	Methods were devised to analyse the data so as to obtain indices of relatedness or relative affinities of each type of heterologous transferrin in rates of iron uptake found with transferrin and cells from various species are largely due to variation in the affinity of cellular receptors for different transferrins.	Iron	156-160	transferrin	Homo sapiens	132-143
6121647-7	1982	Methods were devised to analyse the data so as to obtain indices of relatedness or relative affinities of each type of heterologous transferrin in rates of iron uptake found with transferrin and cells from various species are largely due to variation in the affinity of cellular receptors for different transferrins.	Iron	156-160	transferrin	Homo sapiens	179-190
7153668-3	1982	The control exerted by a hormone, called erythropoietin, on bone marrow utilization of iron for hemoglobin synthesis is taken into account.	Iron	87-91	erythropoietin	Homo sapiens	41-55
7084678-5	1982	The best serological index of iron status was the transferrin saturation, which was less than 12% in significant iron deficiency.	Iron	30-34	transferrin	Homo sapiens	50-61
6286381-3	1982	PAGE studies with a purified membrane complex B2, from which the functional role in transferrin binding and iron uptake has been shown previously, showed that the transferrin receptor is localized on a membrane protein with a mol.	Iron	108-112	transferrin	Rattus norvegicus	163-174
6957530-3	1982	In 19% (Group II) classical iron deficiency was present with low plasma ferritin levels, reduced transferrin saturation and absence of stainable iron in the marrow.	Iron	28-32	transferrin	Homo sapiens	97-108
7298642-15	1981	The results are correlated with an earlier study on the reductive release of iron from transferrin (Kojima, N., and Bates, G. W. (1979) J. Biol.	Iron	77-81	transferrin	Homo sapiens	87-98
6957530-5	1982	The development of overt iron deficiency was associated with a fall in the transferrin saturation and absence of stainable iron in the marrow.	Iron	25-29	transferrin	Homo sapiens	75-86
6287178-2	1982	Serum IgA exerted a bacteriostatic effect in vitro on E. coli and P. aeruginosa, which increased in the presence of the iron-binding proteins lactoferrin and transferrin.	Iron	120-124	CD79a molecule	Homo sapiens	6-9
6287178-7	1982	Iron-chelating substances, siderophores, excreted by E. coli diminished the co-operative bacteriostatic effect of serum IgA and transferrin.	Iron	0-4	CD79a molecule	Homo sapiens	120-123
16593145-0	1982	Picosecond photochemistry of a cofacial diporphyrin containing iron(III) and zinc(II): Mimicking electron transfer between cytochrome c and the primary electron donor in reaction centers of photosynthetic bacteria.	Iron	63-67	cytochrome c, somatic	Homo sapiens	123-135
6171347-1	1981	Inhibition of bleomycin (BLM)-induced DNA breakage by superoxide dismutase (SOD) has been reported and presumed to be due to its removal of the superoxide free radicals generated by BLM in the presence of iron(II).	Iron	205-209	superoxide dismutase 1	Homo sapiens	54-74
6171347-1	1981	Inhibition of bleomycin (BLM)-induced DNA breakage by superoxide dismutase (SOD) has been reported and presumed to be due to its removal of the superoxide free radicals generated by BLM in the presence of iron(II).	Iron	205-209	superoxide dismutase 1	Homo sapiens	76-79
6172227-0	1981	Plasma transferrin and the relation to iron status in patients with chronic uremia.	Iron	39-43	transferrin	Homo sapiens	7-18
6172227-2	1981	Patients with reduced (grade O) hemosiderin marrow iron had higher plasma transferrin (P less than 0.001), lower serum iron (P less than 0.01), transferrin saturation (P less tha 0.001) and serum ferritin (P less than 0.001), and higher iron absorption (P less than 0.001) than patients with "normal" (grade 1+) marrow iron.	Iron	51-55	transferrin	Homo sapiens	74-85
6172227-2	1981	Patients with reduced (grade O) hemosiderin marrow iron had higher plasma transferrin (P less than 0.001), lower serum iron (P less than 0.01), transferrin saturation (P less tha 0.001) and serum ferritin (P less than 0.001), and higher iron absorption (P less than 0.001) than patients with "normal" (grade 1+) marrow iron.	Iron	51-55	transferrin	Homo sapiens	144-155
6172227-4	1981	Plasma transferrin was correlated both to serum ferritin (r = -0.59, P less than 0.001) and iron absorption (r = 0.56, P less than 0.001).	Iron	92-96	transferrin	Homo sapiens	7-18
7307855-0	1981	Properties and hepatic metabolism of non-transferrin-bound iron.	Iron	59-63	transferrin	Homo sapiens	41-52
7307855-1	1981	These experiments have examined the physical properties and the hepatic uptake of non-transferrin-bound iron, a fraction found in the serum of untreated primary hemochromatosis patients.	Iron	104-108	transferrin	Homo sapiens	86-97
7307855-2	1981	Ultrafiltration, polyacrylamide gel electrophoresis, and TLC have demonstrated the non-transferrin-bound iron complex to have a molecular weight less than 1000 and to be distinct from free iron and amino acid iron complexes.	Iron	189-193	transferrin	Homo sapiens	87-98
7307855-3	1981	Hepatic iron uptake from serum containing non-transferrin-bound iron was significantly higher than from the same serum sample from which the abnormal iron had been removed.	Iron	8-12	transferrin	Homo sapiens	46-57
7307855-2	1981	Ultrafiltration, polyacrylamide gel electrophoresis, and TLC have demonstrated the non-transferrin-bound iron complex to have a molecular weight less than 1000 and to be distinct from free iron and amino acid iron complexes.	Iron	105-109	transferrin	Homo sapiens	87-98
7307855-3	1981	Hepatic iron uptake from serum containing non-transferrin-bound iron was significantly higher than from the same serum sample from which the abnormal iron had been removed.	Iron	64-68	transferrin	Homo sapiens	46-57
7307855-3	1981	Hepatic iron uptake from serum containing non-transferrin-bound iron was significantly higher than from the same serum sample from which the abnormal iron had been removed.	Iron	64-68	transferrin	Homo sapiens	46-57
7307855-2	1981	Ultrafiltration, polyacrylamide gel electrophoresis, and TLC have demonstrated the non-transferrin-bound iron complex to have a molecular weight less than 1000 and to be distinct from free iron and amino acid iron complexes.	Iron	189-193	transferrin	Homo sapiens	87-98
7307855-4	1981	Non-transferrin-bound iron entering the liver was localized to the lysosomal fraction in the first hour and was subsequently incompletely incorporated into ferritin.	Iron	22-26	transferrin	Homo sapiens	4-15
6947077-7	1981	Serum iron and iron binding in rats determined 20 hr after MTX therapy showed significantly higher levels of serum iron and lower levels of Ga-67 in blood, and the percent transferrin saturation was approximately 95%.	Iron	15-19	transferrin	Rattus norvegicus	172-183
7320714-1	1981	During commonly used saturation procedures of transferrin with iron compounds, both as ferri and ferrous, polynuclear iron compounds are easily formed, even when nitrilotriacetate (NTA) is used as a strong iron ligand.	Iron	63-67	transferrin	Homo sapiens	46-57
7320714-1	1981	During commonly used saturation procedures of transferrin with iron compounds, both as ferri and ferrous, polynuclear iron compounds are easily formed, even when nitrilotriacetate (NTA) is used as a strong iron ligand.	Iron	118-122	transferrin	Homo sapiens	46-57
7320714-1	1981	During commonly used saturation procedures of transferrin with iron compounds, both as ferri and ferrous, polynuclear iron compounds are easily formed, even when nitrilotriacetate (NTA) is used as a strong iron ligand.	Iron	118-122	transferrin	Homo sapiens	46-57
6947077-7	1981	Serum iron and iron binding in rats determined 20 hr after MTX therapy showed significantly higher levels of serum iron and lower levels of Ga-67 in blood, and the percent transferrin saturation was approximately 95%.	Iron	15-19	transferrin	Rattus norvegicus	172-183
7339737-10	1981	However, the ceruloplasmin in chickens, could play a secondary role in iron mobilization.	Iron	71-75	ceruloplasmin	Gallus gallus	13-26
7310544-0	1981	Response of glutathione peroxidase and catalase to excess dietary iron in rats.	Iron	66-70	catalase	Rattus norvegicus	39-47
7311398-4	1981	In respect to iron metabolism we found the following changes: decreased serum iron concentration (32%), increased iron concentration (42%), increased total iron binding capacity (54%), increased ferritin (41%), decreased transferrin (20%).	Iron	14-18	transferrin	Homo sapiens	221-232
6271255-0	1981	Iron transfer form transferrin to ferritin mediated by polyphosphate compounds.	Iron	0-4	transferrin	Homo sapiens	19-30
6271255-1	1981	We have studied iron transfer from transferrin to ferritin in the presence of ATP, GTP, ADP, AMP and 2,3-diphosphoglycerate.	Iron	16-20	transferrin	Homo sapiens	35-46
6271255-2	1981	These compounds, with the exception of AMP, can release iron from transferrin at pH 7.4 and form a stable Fe(III)-phosphate complex.	Iron	56-60	transferrin	Homo sapiens	66-77
6271255-4	1981	Ascorbate enhances iron transfer from transferrin to ferritin at the beginning of the process but subsequently inhibits further iron deposition in ferritin.	Iron	19-23	transferrin	Homo sapiens	38-49
6117191-2	1981	The addition of L-glutamate resulted in increased cyclic AMP levels in slices from the quarter of cortex with the iron-induced focus.	Iron	114-118	transmembrane serine protease 5	Rattus norvegicus	57-60
7332869-2	1981	This procedure took advantage of the pH dependence and reversibility of iron binding by transferrin and was applicable to both human and mouse transferrins.	Iron	72-76	transferrin	Homo sapiens	88-99
6895846-4	1981	Acute iron overload in rats resulted in a marked increase in hepatic haem oxygenase that was associated with a decrease in cytochrome P-450 and an increase in ALA synthase activity.	Iron	6-10	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	123-139
7288441-5	1981	Indeed, when heat-denatured microsomes were employed, incubation with H2O2 and the iron complex led to formation of lipid hydroperoxides; however, no production of MDA was observed, unless exogenous catalase was added together with H2O2 and hematin to the reaction mixture.	Iron	83-87	catalase	Rattus norvegicus	199-207
7296013-0	1981	Determination of transferrin-like immunoreactivity in the mucosal homogenate of the duodenum, jejunum, and ileum of normal and iron deficient rats.	Iron	127-131	transferrin	Rattus norvegicus	17-28
6795121-1	1981	Small quantities of iron bound specifically to human transferrin were found to stimulate infection with Neisseria meningitidis strain M1011 in mice.	Iron	20-24	transferrin	Homo sapiens	53-64
7288441-8	1981	Catalase is necessary to remove H2O2, which, after starting the peroxidation process, blocks the decomposition of lipid hydroperoxides, apparently by binding to the iron complex.	Iron	165-169	catalase	Rattus norvegicus	0-8
7252850-11	1981	It is concluded that erythromycin induces its own transformation into a metabolite which forms a inactive 456-nm absorbing complex with the iron (II) of cytochrome P-450.	Iron	140-144	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	153-169
7295776-2	1981	Reduced P-450SCC at pH 7.4 exhibited the V4 line at 1342 cm-1, which is an unusually low frequency compared with an ordinary protohemoprotein but is common to the family of cytochrome P-450, suggesting the coordination of a strong pi-donor such as thiolate anion at the fifth coordination position of the heme iron.	Iron	310-314	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	8-16
7295776-2	1981	Reduced P-450SCC at pH 7.4 exhibited the V4 line at 1342 cm-1, which is an unusually low frequency compared with an ordinary protohemoprotein but is common to the family of cytochrome P-450, suggesting the coordination of a strong pi-donor such as thiolate anion at the fifth coordination position of the heme iron.	Iron	310-314	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	173-189
7319458-4	1981	The results were summarized as follows: 1) Even in the group in which only CCl4 was given without any iron solution, positive iron granules were found in Kupffer cells or macrophages at the central necrotic zone of hepatic lobules.	Iron	126-130	C-C motif chemokine 4	Canis lupus familiaris	75-79
7319458-13	1981	And also the slope of the regression line in the group in which colloidal iron was administered with CCl4 was steeper than that in the group without CCl4 (Fig.	Iron	74-78	C-C motif chemokine 4	Canis lupus familiaris	101-105
7319458-15	1981	5) In the group in which colloidal iron was administered with CCl4, marked iron deposition was observed in Kupffer cells or macrophages at the central necrotic zone of hepatic lobules, and accompanied by hepatic fibrosis in chronic cases.	Iron	35-39	C-C motif chemokine 4	Canis lupus familiaris	62-66
7319458-15	1981	5) In the group in which colloidal iron was administered with CCl4, marked iron deposition was observed in Kupffer cells or macrophages at the central necrotic zone of hepatic lobules, and accompanied by hepatic fibrosis in chronic cases.	Iron	75-79	C-C motif chemokine 4	Canis lupus familiaris	62-66
6269606-7	1981	We interpret the long lifetime of the transient state as due to the slow return of Met-80 as sixth ligand to the heme iron upon reduction of the alkaline form of cytochrome c.	Iron	118-122	cytochrome c, somatic	Homo sapiens	162-174
7295641-0	1981	Distance between metal-binding sites in transferrin: energy transfer from bound terbium (III) to iron (III) or manganese (III).	Iron	97-101	transferrin	Homo sapiens	40-51
6268404-0	1981	Studies on the mechanism of pyrophosphate-mediated uptake of iron from transferrin by isolated rat-liver mitochondria.	Iron	61-65	transferrin	Rattus norvegicus	71-82
7038780-6	1981	(1) The serum iron concentration was significantly decreased between 3 and 6 hours after 10 Gy (1,000 rad) dose whole-body 60Co-irradiation.	Iron	14-18	Ras-related associated with diabetes	Mus musculus	102-105
7322990-0	1981	Plasma variation of transferrin-iron and phosvitin-iron during the laying period in chicken hens.	Iron	51-55	Casein kinase II subunit beta	Gallus gallus	41-50
7322990-1	1981	The distribution of plasma iron between transferrin-iron (Tf-Fe) and phosvitin-iron (Phv-Fe) over a 98 week laying period was established in hens.	Iron	27-31	Casein kinase II subunit beta	Gallus gallus	69-78
6268404-2	1981	Respiring rat liver mitochondria accumulate iron released from transferrin by pyrophosphate.	Iron	44-48	transferrin	Rattus norvegicus	63-74
6268404-3	1981	The amount of iron accumulated is 1--1.5 nmol mg protein-1 h-1, or approximately 60% of the amount of iron mobilized from transferrin.	Iron	14-18	transferrin	Rattus norvegicus	122-133
6268404-3	1981	The amount of iron accumulated is 1--1.5 nmol mg protein-1 h-1, or approximately 60% of the amount of iron mobilized from transferrin.	Iron	102-106	transferrin	Rattus norvegicus	122-133
6268404-13	1981	The results are compatible with a model in which ferric iron is mobilized from transferrin by pyrophosphate, ferric iron pyrophosphate is bound to the mitochondria, iron is reduced, dissociates from pyrophosphate and is taken up by the mitochondria.	Iron	56-60	transferrin	Rattus norvegicus	79-90
7253052-1	1981	A prospective study was undertaken to evaluate the utility of calculating transferrin from total iron-binding capacity in the nutritional assessment of burned patients.	Iron	97-101	transferrin	Homo sapiens	74-85
7253052-9	1981	From our studies, the formula for conversion of total iron-binding capacity to transferrin was found to be (0.68 TIBC + 21).	Iron	54-58	transferrin	Homo sapiens	79-90
6271283-7	1981	It is clear that myocytes acquire iron from diferric (ovo)transferrin in a process that involves high-affinity, specific binding to membrane receptors.	Iron	34-38	transferrin	Rattus norvegicus	58-69
6264804-4	1981	After 8 days of iron treatment, respiratory capacity, cytochrome c, cytochrome oxidase, and glycerol-3-phosphate dehydrogenase had returned 50% toward normal.	Iron	16-20	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	92-126
7229753-1	1981	The purpose of this study was to determine the Hgb response to a therapeutic trial of iron in infants with anemia compared to those with low-normal hemoglobin values.	Iron	86-90	cytoglobin	Homo sapiens	47-50
7237011-5	1981	We believe that by saturating the free transferrin with iron, uptake into soft tissues and bone is sufficiently modified to enhance the lesion-to-background ratio, thereby making earlier imaging and diagnosis possible.	Iron	56-60	transferrin	Homo sapiens	39-50
7229753-7	1981	Because of the low cost and simplicity of a therapeutic trial, we favor including the low-normal Hgb group for a therapeutic trial of iron in order to avoid missing iron-responsive individuals among groups of infants with a similarly high prevalence of iron deficiency anemia.	Iron	165-169	cytoglobin	Homo sapiens	97-100
6895546-0	1981	Xanthine oxidase in intestinal mucosa promotes incorporation of iron into transferrin.	Iron	64-68	transferrin	Homo sapiens	74-85
6113846-0	1981	Inactivation of tyrosine 3-monooxygenase by acetone precipitation and its restoration by incubation with a sulfhydryl agent and iron.	Iron	128-132	tyrosine hydroxylase	Homo sapiens	16-40
7305958-0	1981	The influence of pH on the equilibrium distribution of iron between the metal-binding sites of human transferrin.	Iron	55-59	transferrin	Homo sapiens	101-112
7306080-11	1981	(3) Hepatic cytochrome P-450 decreased after iron treatment to a minimum (63% of control) at 48 h after iron administration and gradually returned to the control value by 28 days.	Iron	45-49	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	12-28
7306080-11	1981	(3) Hepatic cytochrome P-450 decreased after iron treatment to a minimum (63% of control) at 48 h after iron administration and gradually returned to the control value by 28 days.	Iron	104-108	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	12-28
7213573-2	1981	Following prelabelling in vivo with transferrin-59Fe, isolated hepatocytes released radioactive iron in vitro by a temperature dependent process, without change in cell viability.	Iron	96-100	transferrin	Homo sapiens	36-47
6941310-0	1981	Uptake and release of iron from human transferrin.	Iron	22-26	transferrin	Homo sapiens	38-49
6941310-3	1981	Iron release from the two monoferric transferrin preparations to human reticulocytes was of similar magnitude.	Iron	0-4	transferrin	Homo sapiens	37-48
6941310-5	1981	Iron loading of transferrin in vitro showed a random distribution between monoferric and diferric transferrin.	Iron	0-4	transferrin	Homo sapiens	16-27
6941310-5	1981	Iron loading of transferrin in vitro showed a random distribution between monoferric and diferric transferrin.	Iron	0-4	transferrin	Homo sapiens	98-109
6941310-8	1981	Absorption of a large dose of orally administered iron in iron-deficient subjects resulted in a somewhat greater amount of diferric transferrin at low saturation and a somewhat smaller amount of diferric transferrin at higher saturations than would have been anticipated by random loading.	Iron	50-54	transferrin	Homo sapiens	132-143
6941310-8	1981	Absorption of a large dose of orally administered iron in iron-deficient subjects resulted in a somewhat greater amount of diferric transferrin at low saturation and a somewhat smaller amount of diferric transferrin at higher saturations than would have been anticipated by random loading.	Iron	50-54	transferrin	Homo sapiens	204-215
6941310-8	1981	Absorption of a large dose of orally administered iron in iron-deficient subjects resulted in a somewhat greater amount of diferric transferrin at low saturation and a somewhat smaller amount of diferric transferrin at higher saturations than would have been anticipated by random loading.	Iron	58-62	transferrin	Homo sapiens	132-143
6941310-8	1981	Absorption of a large dose of orally administered iron in iron-deficient subjects resulted in a somewhat greater amount of diferric transferrin at low saturation and a somewhat smaller amount of diferric transferrin at higher saturations than would have been anticipated by random loading.	Iron	58-62	transferrin	Homo sapiens	204-215
6941310-9	1981	These data would indicate that in the human, iron loading of transferrin may be considered essentially random.	Iron	45-49	transferrin	Homo sapiens	61-72
7305958-2	1981	Equations are presented for calculating the relative values of the four conditional site constants for the stepwise binding of iron to the two sites of transferrin and for calculating the equilibrium distribution of the protein among the four principal forms, apotransferrin, the C-terminal and N-terminal monoferric transferrins and diferric transferrin.	Iron	127-131	transferrin	Homo sapiens	152-163
7459282-3	1981	Iron bound to human transferrin but not apotransferrin, increases the effect of erythropoietin in stimulating incorporation of 3H-thymidine into DNA in fetal mouse liver cells in vitro.	Iron	0-4	transferrin	Homo sapiens	20-31
7459282-3	1981	Iron bound to human transferrin but not apotransferrin, increases the effect of erythropoietin in stimulating incorporation of 3H-thymidine into DNA in fetal mouse liver cells in vitro.	Iron	0-4	erythropoietin	Homo sapiens	80-94
7448423-4	1981	Only part of this effect in the rat was due to the different rates of clearance of mono-and differic transferrin, the latter having a higher iron delivery rate in vivo.	Iron	141-145	transferrin	Rattus norvegicus	101-112
6269977-1	1981	Isolated rat hepatocytes accumulate iron from iron-transferrin by a process which is dependent on the temperature and on the transferrin concentration, and which is diminished by treatment of the cells with a proteolytic enzyme.	Iron	36-40	transferrin	Rattus norvegicus	51-62
6269977-1	1981	Isolated rat hepatocytes accumulate iron from iron-transferrin by a process which is dependent on the temperature and on the transferrin concentration, and which is diminished by treatment of the cells with a proteolytic enzyme.	Iron	36-40	transferrin	Rattus norvegicus	125-136
6269977-1	1981	Isolated rat hepatocytes accumulate iron from iron-transferrin by a process which is dependent on the temperature and on the transferrin concentration, and which is diminished by treatment of the cells with a proteolytic enzyme.	Iron	46-50	transferrin	Rattus norvegicus	51-62
6269977-1	1981	Isolated rat hepatocytes accumulate iron from iron-transferrin by a process which is dependent on the temperature and on the transferrin concentration, and which is diminished by treatment of the cells with a proteolytic enzyme.	Iron	46-50	transferrin	Rattus norvegicus	125-136
6269977-2	1981	These observations are consistent with a mechanism for iron uptake into hepatocytes involving the binding of iron-transferrin to a specific cell-surface receptor.	Iron	55-59	transferrin	Rattus norvegicus	114-125
6269977-2	1981	These observations are consistent with a mechanism for iron uptake into hepatocytes involving the binding of iron-transferrin to a specific cell-surface receptor.	Iron	109-113	transferrin	Rattus norvegicus	114-125
6269977-3	1981	Apotransferrin is also able to bind to the hepatocyte but the apparent binding constant is about 35 times lower than that observed for the binding of iron-transferrin.	Iron	150-154	transferrin	Rattus norvegicus	3-14
6269977-4	1981	The binding of apotransferrin to the cells is completely abolished by a low concentration of iron-transferrin.	Iron	93-97	transferrin	Rattus norvegicus	18-29
6269977-5	1981	This suggests that the apotransferrin is binding weakly to the same receptor to which iron-transferrin binds and that there are not receptors on the surface of the hepatocyte specific for apotransferrin.	Iron	86-90	transferrin	Rattus norvegicus	26-37
7448422-0	1981	The behavior of transferrin iron in the rat.	Iron	28-32	transferrin	Rattus norvegicus	16-27
7448422-3	1981	Complete and specific binding of 59FeSO4 by the iron binding sites of transferrin was demonstrated after in vitro or in vivo addition of ferrous ammonium sulfate in pH 2 saline up to the point of iron saturation.	Iron	48-52	transferrin	Rattus norvegicus	70-81
7448422-3	1981	Complete and specific binding of 59FeSO4 by the iron binding sites of transferrin was demonstrated after in vitro or in vivo addition of ferrous ammonium sulfate in pH 2 saline up to the point of iron saturation.	Iron	196-200	transferrin	Rattus norvegicus	70-81
7448422-4	1981	In vitro the radioriron transferrin complex in plasma was stable and its iron had a negligible exchange with other transferrin binding sites over several hours.	Iron	19-23	transferrin	Rattus norvegicus	24-35
7448422-4	1981	In vitro the radioriron transferrin complex in plasma was stable and its iron had a negligible exchange with other transferrin binding sites over several hours.	Iron	19-23	transferrin	Rattus norvegicus	115-126
7237932-2	1981	According to the Fletcher-Huehns hypothesis there exists a functional difference between the two iron-binding sites of transferrin.	Iron	97-101	transferrin	Homo sapiens	119-130
7448422-6	1981	Iron distribution among body tissues was similar for mono- and diferric transferrin iron and was not affected by the site distribution of iron on the transferrin molecule.	Iron	0-4	transferrin	Rattus norvegicus	72-83
7448422-7	1981	The only important aspect of transferrin iron binding was the more rapid tissue uptake of iron in the diferric form was compared to monoferric transferrin.	Iron	41-45	transferrin	Rattus norvegicus	29-40
7448422-7	1981	The only important aspect of transferrin iron binding was the more rapid tissue uptake of iron in the diferric form was compared to monoferric transferrin.	Iron	41-45	transferrin	Rattus norvegicus	143-154
7448422-7	1981	The only important aspect of transferrin iron binding was the more rapid tissue uptake of iron in the diferric form was compared to monoferric transferrin.	Iron	90-94	transferrin	Rattus norvegicus	29-40
7448422-9	1981	In the iron loaded animal, monoferric transferrin injected into the plasma was rapidly loaded by iron from tissue and thereby converted to diferric transferrin.	Iron	7-11	transferrin	Rattus norvegicus	38-49
7448422-9	1981	In the iron loaded animal, monoferric transferrin injected into the plasma was rapidly loaded by iron from tissue and thereby converted to diferric transferrin.	Iron	7-11	transferrin	Rattus norvegicus	148-159
7448422-9	1981	In the iron loaded animal, monoferric transferrin injected into the plasma was rapidly loaded by iron from tissue and thereby converted to diferric transferrin.	Iron	97-101	transferrin	Rattus norvegicus	38-49
7448422-9	1981	In the iron loaded animal, monoferric transferrin injected into the plasma was rapidly loaded by iron from tissue and thereby converted to diferric transferrin.	Iron	97-101	transferrin	Rattus norvegicus	148-159
7448422-10	1981	Injection of diferric transferrin in the iron deficient animal was associated with a rapid disappearance from circulation of the original complex and a subsequent appearance of monoferric transferrin as a result of iron returning from tissues.	Iron	41-45	transferrin	Rattus norvegicus	22-33
7448422-10	1981	Injection of diferric transferrin in the iron deficient animal was associated with a rapid disappearance from circulation of the original complex and a subsequent appearance of monoferric transferrin as a result of iron returning from tissues.	Iron	41-45	transferrin	Rattus norvegicus	188-199
7448422-10	1981	Injection of diferric transferrin in the iron deficient animal was associated with a rapid disappearance from circulation of the original complex and a subsequent appearance of monoferric transferrin as a result of iron returning from tissues.	Iron	215-219	transferrin	Rattus norvegicus	22-33
7448422-10	1981	Injection of diferric transferrin in the iron deficient animal was associated with a rapid disappearance from circulation of the original complex and a subsequent appearance of monoferric transferrin as a result of iron returning from tissues.	Iron	215-219	transferrin	Rattus norvegicus	188-199
7237932-10	1981	In a heterogeneous but more active system for the removal of iron from human transferrin in vitro the two human monoferric transferrins did not show any significant functional differences.	Iron	61-65	transferrin	Homo sapiens	77-88
6451701-5	1981	In vitro kinetic experiments have shown that 10 rapidly and quantitatively removed Fe from human transferrin.	Iron	83-85	transferrin	Homo sapiens	97-108
7256213-2	1981	Non-specific iron was found only in the sera of those patients with beta-thalassaemia trait plus chronic active hepatitis who had complete transferrin saturation, high serum ferritin levels and urinary iron excretion and a high degree of hepatic siderosis.	Iron	13-17	transferrin	Homo sapiens	139-150
7256213-3	1981	In view of the known toxicity of non-transferrin iron, we suggest that this non-transferrin iron fraction may be responsible for the liver damage in these patients.	Iron	92-96	transferrin	Homo sapiens	80-91
7256213-4	1981	Furthermore, the positive correlation between the presence and the amount of non-transferrin iron and the levels of serum ferritin suggests that this fraction is a sensitive indicator of iron-induced toxicity when severe iron overload slowly develops in patients with beta-thalassaemia trait even in the absence of any iron administration.	Iron	93-97	transferrin	Homo sapiens	81-92
7256213-4	1981	Furthermore, the positive correlation between the presence and the amount of non-transferrin iron and the levels of serum ferritin suggests that this fraction is a sensitive indicator of iron-induced toxicity when severe iron overload slowly develops in patients with beta-thalassaemia trait even in the absence of any iron administration.	Iron	187-191	transferrin	Homo sapiens	81-92
7256213-4	1981	Furthermore, the positive correlation between the presence and the amount of non-transferrin iron and the levels of serum ferritin suggests that this fraction is a sensitive indicator of iron-induced toxicity when severe iron overload slowly develops in patients with beta-thalassaemia trait even in the absence of any iron administration.	Iron	187-191	transferrin	Homo sapiens	81-92
7256213-4	1981	Furthermore, the positive correlation between the presence and the amount of non-transferrin iron and the levels of serum ferritin suggests that this fraction is a sensitive indicator of iron-induced toxicity when severe iron overload slowly develops in patients with beta-thalassaemia trait even in the absence of any iron administration.	Iron	187-191	transferrin	Homo sapiens	81-92
6800190-9	1981	The observation is compatible with previous observations that splenectomy in thalassemia is associated with increased iron deposition and increased transferrin iron saturation.	Iron	160-164	transferrin	Homo sapiens	148-159
7234508-4	1981	The average transferrin iron-binding capacity was 80 mu mol/l serum in the women and 77 (iron-binding groups) in the men.	Iron	24-28	transferrin	Homo sapiens	12-23
7234508-4	1981	The average transferrin iron-binding capacity was 80 mu mol/l serum in the women and 77 (iron-binding groups) in the men.	Iron	89-93	transferrin	Homo sapiens	12-23
7234508-8	1981	Oral iron therapy (200 mg ferrous sulphate per day) normalized the hemoglobin concentration and improved the transferrin saturation fraction in 61 persons.	Iron	5-9	transferrin	Homo sapiens	109-120
6452038-4	1981	Such activity is abolished if the transferrin is saturated with iron.	Iron	64-68	transferrin	Homo sapiens	34-45
6452038-9	1981	On the other hand, in cases of systemic infection, the organism responds by lowering its total serum iron, so as to make the serotransferrin present less saturated with iron.	Iron	101-105	transferrin	Homo sapiens	125-140
6452038-9	1981	On the other hand, in cases of systemic infection, the organism responds by lowering its total serum iron, so as to make the serotransferrin present less saturated with iron.	Iron	169-173	transferrin	Homo sapiens	125-140
7283960-3	1981	Among the deficiencies, iron is the most frequent, affecting particularly young children and women of childbearing age as reflected by relatively low intakes and relatively high prevalences of low hemoglobin values and percent transferrin saturations.	Iron	24-28	transferrin	Homo sapiens	227-238
6264452-1	1981	Methods have been devised for preparing human transferrin with a different isotope of iron selectively labeling each of the two iron binding sites and for determining the distribution of radioiron among transferrin molecules.	Iron	86-90	transferrin	Homo sapiens	46-57
6258634-1	1981	The nonceruloplasmin enzyme located in the intestinal mucosa which promotes the incorporation of iron into transferrin has been resolved into a small, heat-stable component and a heat-labile protein component.	Iron	97-101	transferrin	Homo sapiens	107-118
6258634-5	1981	By promotion of the oxidation and incorporation of iron into transferrin, intestinal xanthine oxidase could perform a similar function in iron absorption as ceruloplasmin serves in the mobilization of iron from liver stores.	Iron	51-55	transferrin	Homo sapiens	61-72
6258634-5	1981	By promotion of the oxidation and incorporation of iron into transferrin, intestinal xanthine oxidase could perform a similar function in iron absorption as ceruloplasmin serves in the mobilization of iron from liver stores.	Iron	138-142	transferrin	Homo sapiens	61-72
6258634-5	1981	By promotion of the oxidation and incorporation of iron into transferrin, intestinal xanthine oxidase could perform a similar function in iron absorption as ceruloplasmin serves in the mobilization of iron from liver stores.	Iron	138-142	transferrin	Homo sapiens	61-72
7329981-4	1981	The relative risk of iron overload was calculated to be 2.0 for HLA A3 and 8.7 for HLA B7.	Iron	21-25	major histocompatibility complex, class I, A	Homo sapiens	64-69
6264452-3	1981	In this delivery, both atoms of iron were removed simultaneously from the diferric transferrin molecule, converting it to apotransferrin.	Iron	32-36	transferrin	Homo sapiens	83-94
6264452-4	1981	At similar iron concentrations the amount of iron delivered by diferric transferrin was twice that delivered by monoferric transferrin.	Iron	45-49	transferrin	Homo sapiens	72-83
6264452-4	1981	At similar iron concentrations the amount of iron delivered by diferric transferrin was twice that delivered by monoferric transferrin.	Iron	45-49	transferrin	Homo sapiens	123-134
7459386-4	1980	Uptake of iron from diferic transferrin by hepatocytes is linear with time and is accelerated at increased diferric transferrin concentrations.	Iron	10-14	transferrin	Rattus norvegicus	28-39
7459386-4	1980	Uptake of iron from diferic transferrin by hepatocytes is linear with time and is accelerated at increased diferric transferrin concentrations.	Iron	10-14	transferrin	Rattus norvegicus	116-127
7437510-1	1980	Using highly sensitive 2-site immunoradiometric assays, we examined the relationship between iron absorption from closed intestinal loops and transferrin and ferritin concentrations in isolated duodenal mucosal cells.	Iron	93-97	transferrin	Rattus norvegicus	142-153
7459386-5	1980	Apotransferrin is able to decrease net iron uptake by hepatocytes from diferric transferrin by a process not dependent on the apotransferrin concentrations used or on the rate at which the cells take up iron.	Iron	39-43	transferrin	Rattus norvegicus	3-14
7437510-4	1980	The highest correlation with iron absorption was observed with the transferrin-ferritin ratio in isolated mucosal cells.	Iron	29-33	transferrin	Rattus norvegicus	67-78
7459386-5	1980	Apotransferrin is able to decrease net iron uptake by hepatocytes from diferric transferrin by a process not dependent on the apotransferrin concentrations used or on the rate at which the cells take up iron.	Iron	203-207	transferrin	Rattus norvegicus	3-14
7459386-6	1980	Immunoprecipitation of the apotransferrin during these incubations indicate that iron is being released from the cells to apotransferrin at the same time as iron is being taken up from diferric transferrin.	Iron	81-85	transferrin	Rattus norvegicus	30-41
7459386-6	1980	Immunoprecipitation of the apotransferrin during these incubations indicate that iron is being released from the cells to apotransferrin at the same time as iron is being taken up from diferric transferrin.	Iron	157-161	transferrin	Rattus norvegicus	30-41
6253579-2	1980	F-transferrin saturated with iron was used as probe of the available receptor sites on reticulocytes and nucleated red cells.	Iron	29-33	transferrin	Homo sapiens	2-13
7448127-1	1980	A recently developed crossed immunoelectrophoretic method for displaying and quantitating the four possible molecular species of transferrin has been utilized to assess the relative effectiveness of each site of rabbit and human diferric transferrin in providing iron to rabbit reticulocytes.	Iron	263-267	transferrin	Homo sapiens	238-249
7437473-1	1980	A high level of non-heme iron (either labelled or unlabelled) in mitochondria, ferritin and low-molecular-weight pool of reticulocytes was induced by preincubation with isonicotinic acid hydrazide or penicillamine together with either 59Fe- of 56Fe-labelled transferrin.	Iron	25-29	transferrin	Homo sapiens	258-269
7437473-3	1980	Similarly, when cells were reincubated with 125I-labelled transferrin, more 125I-labelled radioactivity was found, in both free and carrier-bound transferrin peaks, in reticulocytes with a high level of low-molecular-weight cold iron than in control ones.	Iron	229-233	transferrin	Homo sapiens	58-69
7437473-4	1980	These results suggest that transferrin enters reticulocytes and takes up iron from low-molecular-weight pool.	Iron	73-77	transferrin	Homo sapiens	27-38
7437475-0	1980	Studies on the mechanism of transferrin iron uptake by rat reticulocytes.	Iron	40-44	transferrin	Rattus norvegicus	28-39
7437475-1	1980	Mechanism of transferrin iron uptake by rat reticulocytes was studied using 59Fe- and 125I-labelled rat transferrin.	Iron	25-29	transferrin	Rattus norvegicus	13-24
7437475-1	1980	Mechanism of transferrin iron uptake by rat reticulocytes was studied using 59Fe- and 125I-labelled rat transferrin.	Iron	25-29	transferrin	Rattus norvegicus	104-115
7448127-5	1980	In human diferric transferrin, the site in the C-terminal domain functions as the better iron donor for rabbit reticulocytes.	Iron	89-93	transferrin	Homo sapiens	18-29
6254532-0	1980	Iron transfer from transferrin to ferritin mediated by pyrophosphate.	Iron	0-4	transferrin	Homo sapiens	19-30
6779862-2	1980	In addition, both monoferric forms of the protein were studied, as well as the diferric complex formed by using oxalate instead of (bi)carbonate as the auxiliary anion in binding of iron(III) to transferrin.	Iron	182-186	transferrin	Homo sapiens	195-206
6779862-3	1980	Second-order rate constants for energy transfer between electrically neutral terbium(III)--N-(2-hydroxy-ethyl)ethylenediaminetriacetate and the FeA, FeB, and Fe2 forms of transferrin were 0.9 X 10(5) M-1 S-1, 1.4 X 10(5) M-1 S-1, and 2.6 X 10(5) M-1 S-1, respectively (based on iron concentraton).	Iron	278-282	transferrin	Homo sapiens	171-182
7428118-6	1980	Moreover, when bound as an axial ligand to the iron atom at the heme site in cytochrome P-450, a carbene complex is formed which gives calculated spectral characteristics consistent with those observed when excess halothane is added to reduced cytochrome P-450 or rat liver microsomes under anaerobic conditions.	Iron	47-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-93
7428118-6	1980	Moreover, when bound as an axial ligand to the iron atom at the heme site in cytochrome P-450, a carbene complex is formed which gives calculated spectral characteristics consistent with those observed when excess halothane is added to reduced cytochrome P-450 or rat liver microsomes under anaerobic conditions.	Iron	47-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	244-260
7426445-0	1980	Increased transferrin iron saturation in splenectomized thalassaemic patients.	Iron	22-26	transferrin	Homo sapiens	10-21
6270774-3	1980	No strict correlation was found between the bacteriostatic capacity of the serum and the process of saturation with iron of transferrin, probably due to participation in the bacteriostatic effect of other factors beside transferrin.	Iron	116-120	transferrin	Homo sapiens	124-135
7213345-1	1980	The denaturation of transferrin by urea has been studied by (a) electrophoresis in polyacrylamide gels incorporating a urea gradient, (b) measurements of the loss of iron-binding capacity and (c) u.v.	Iron	166-170	transferrin	Homo sapiens	20-31
7213345-3	1980	In human serum transferrin and hen ovotransferrin the N-terminal and C-terminal domains of the iron-free protein were found to denature at different urea concentrations.	Iron	95-99	transferrin	Homo sapiens	15-26
7412500-0	1980	Transferrin acquisition of catabolized erythrocyte iron in the rat.	Iron	51-55	transferrin	Rattus norvegicus	0-11
6107844-7	1980	An interesting finding was the negative significant correlation (r = 0.69) between the two iron binding proteins in serum, transferrin and ferritin.	Iron	91-95	transferrin	Homo sapiens	123-134
6107844-8	1980	In summary, the simple radial immunodiffusion technique for transferrin with its minimal requirement of serum can be recommended for pediatric routine laboratories in the differential diagnosis of anemia and hyposideremia, before unnecessary iron medication is institued.	Iron	242-246	transferrin	Homo sapiens	60-71
18962768-1	1980	Iron(III) can be separated from copper(II) and many other elements by eluting these from a column of AG1-X4 anion-exchange resin with 8M hydrochloric acid, while iron(III) is retained and can be eluted with 0.1M hydrochloric acid.	Iron	0-4	NBPF member 10	Homo sapiens	101-104
7417489-4	1980	Rabbit reticulocytes readily took up iron from bovine transferrin, but only slight uptake occurred from the C-terminal fragment (S), and almost none from the N-terminal fragment (F).	Iron	37-41	serotransferrin	Bos taurus	54-65
6188656-5	1982	Erythroblasts will only take their iron from plasma transferrin.	Iron	35-39	transferrin	Homo sapiens	52-63
7417489-7	1980	Binding of transferrin and fragment S, but not of fragment F, was reduced when incubation was performed at 4 degrees C instead of 37 degrees C, and all iron uptake was abolisehd.	Iron	152-156	serotransferrin	Bos taurus	11-22
6188656-10	1982	Part of the iron is being delivered again to plasma transferrin.	Iron	12-16	transferrin	Homo sapiens	52-63
7417489-9	1980	Preincubation of reticulocytes with fragment S, but not with fragment F, somewhat reduced subsequent iron uptake from transferrin.	Iron	101-105	serotransferrin	Bos taurus	118-129
7417489-11	1980	The presence of bovine serum albumin (40 mg/ml) in the incubation buffer inhibited iron uptake, but iron uptake nevertheless occurred from transferrin in bovine serum.	Iron	100-104	serotransferrin	Bos taurus	139-150
7426440-3	1980	The mean rate of efflux into a plasma pool containing normal iron and transferrin concentrations was 0.9% of the initial hepatic radioactive iron pool per hour.	Iron	141-145	transferrin	Rattus norvegicus	70-81
7426440-10	1980	However, increasing the iron concentration in the perfusate by the addition of iron-saturated transferrin without any reduction in the unsaturated iron binding capacity additionally increased iron release into plasma and EBM.	Iron	24-28	transferrin	Rattus norvegicus	94-105
7426440-10	1980	However, increasing the iron concentration in the perfusate by the addition of iron-saturated transferrin without any reduction in the unsaturated iron binding capacity additionally increased iron release into plasma and EBM.	Iron	79-83	transferrin	Rattus norvegicus	94-105
7426440-10	1980	However, increasing the iron concentration in the perfusate by the addition of iron-saturated transferrin without any reduction in the unsaturated iron binding capacity additionally increased iron release into plasma and EBM.	Iron	79-83	transferrin	Rattus norvegicus	94-105
7407061-0	1980	Binding of iron from nitrilotriacetate analogues by human transferrin.	Iron	11-15	transferrin	Homo sapiens	58-69
7398669-5	1980	We believe that by saturating the free transferrin with iron, uptake into normal soft tissues may be modified sufficiently to enhance significantly the tumour to background ratio, thereby making earlier scanning possible.	Iron	56-60	transferrin	Homo sapiens	39-50
7410898-6	1980	Results of culture in medium with unsaturated transferrin followed by replenishment with iron indicated that iron deprivation was either fungistatic or fungicidal, depending on the yeast strain and, in serum-free medium, on the iron content of transferrin.	Iron	109-113	transferrin	Homo sapiens	46-57
7410898-6	1980	Results of culture in medium with unsaturated transferrin followed by replenishment with iron indicated that iron deprivation was either fungistatic or fungicidal, depending on the yeast strain and, in serum-free medium, on the iron content of transferrin.	Iron	109-113	transferrin	Homo sapiens	244-255
7410898-6	1980	Results of culture in medium with unsaturated transferrin followed by replenishment with iron indicated that iron deprivation was either fungistatic or fungicidal, depending on the yeast strain and, in serum-free medium, on the iron content of transferrin.	Iron	109-113	transferrin	Homo sapiens	46-57
7410898-6	1980	Results of culture in medium with unsaturated transferrin followed by replenishment with iron indicated that iron deprivation was either fungistatic or fungicidal, depending on the yeast strain and, in serum-free medium, on the iron content of transferrin.	Iron	109-113	transferrin	Homo sapiens	244-255
7410898-8	1980	Thus, susceptibility of yeast-phase H. capsulatum to iron starvation by unsaturated transferrin may contribute to their low virulence in vivo.	Iron	53-57	transferrin	Homo sapiens	84-95
6250582-8	1980	Lactoferrin is known to differ from serum transferrin in its enhanced affinity for iron.	Iron	83-87	transferrin	Homo sapiens	42-53
7407237-3	1980	All derivatives have split ellipticity bands, suggesting that lactoperoxidase has a narrow heme pocket that prevents ligands forming linear iron-ligand bonds.	Iron	140-144	lactoperoxidase	Homo sapiens	62-77
7407237-6	1980	Reduction of lactoperoxidase with dithionite gives two forms, indicating that after reduction some compound arising from dithionite binds in the vicinity of the heme iron.	Iron	166-170	lactoperoxidase	Homo sapiens	13-28
7388179-6	1980	When requirements for transferrin iron were increased by exchange transfusion with high reticulocyte blood, within minutes there was a doubling of the rate of tissue iron donation.	Iron	34-38	transferrin	Homo sapiens	22-33
7447387-2	1980	Copper may interfere with iron absorption by binding to mucosal transferrin.	Iron	26-30	transferrin	Homo sapiens	64-75
7388179-6	1980	When requirements for transferrin iron were increased by exchange transfusion with high reticulocyte blood, within minutes there was a doubling of the rate of tissue iron donation.	Iron	166-170	transferrin	Homo sapiens	22-33
7388179-8	1980	It is proposed that there is some direct mechanism that determines the movement of iron from donor tissues to unsaturated transferrin binding sites.	Iron	83-87	transferrin	Homo sapiens	122-133
7411140-4	1980	Biochem., 13-5-R122, Toronto, Canada) was extended to the vanadium in the biochemical mechanisms which involve the exchange of iron between transferrin and ferritin.	Iron	127-131	transferrin	Rattus norvegicus	140-151
6250833-8	1980	The amount of heme iron derived from the eosinophil peroxidase, determined from electron paramagnetic spectra, is 13.2 X 10(-17) mol/eosinophil.	Iron	19-23	eosinophil peroxidase	Homo sapiens	41-62
7406905-0	1980	Iron-chelating agents and the reductive removal of iron from transferrin.	Iron	51-55	transferrin	Homo sapiens	61-72
7405144-1	1980	The biotic doses of trace elements (iron, copper, and manganese) contained by hemostimulin exert a favourable effect on working capacity of athletes, hemopoiesis, catalase and ceruloplasmin activity as well as on transferrin saturation with iron.	Iron	36-40	catalase	Homo sapiens	163-171
7405144-1	1980	The biotic doses of trace elements (iron, copper, and manganese) contained by hemostimulin exert a favourable effect on working capacity of athletes, hemopoiesis, catalase and ceruloplasmin activity as well as on transferrin saturation with iron.	Iron	36-40	transferrin	Homo sapiens	213-224
6256861-6	1980	The hypothesis of an inappropriate secretion of erythropoietin seems admitted, three factors playing probably a role in the occurrence of the polycythaemia: size of the fibroma, state of the iron stores and presence of an inhibitory factor against erythropoiesis.	Iron	191-195	erythropoietin	Homo sapiens	48-62
6902969-0	1980	The role of plasma transferrin in iron absorption in the rat.	Iron	34-38	transferrin	Rattus norvegicus	19-30
6902969-4	1980	The rate of exchange were insufficient for transferrin to act as the carrier of iron at the rate at which it passes from intestinal cells to portal plasma after ingesting a dose of inorganic iron.	Iron	80-84	transferrin	Rattus norvegicus	43-54
6902969-5	1980	Some specific binding of transferrin and cellular uptake of iron by intestinal mucosa was observed after the intravenous injection of transferrin labelled with 59Fe and 125I.	Iron	60-64	transferrin	Rattus norvegicus	134-145
6902969-7	1980	The passage of plasma transferrin into the interstitial fluid of the intestinal mucosa and binding to mucosal cells probably functions primarily to supply iron to the cells and not to act as a carrier of iron from the cells.	Iron	155-159	transferrin	Rattus norvegicus	22-33
6902969-7	1980	The passage of plasma transferrin into the interstitial fluid of the intestinal mucosa and binding to mucosal cells probably functions primarily to supply iron to the cells and not to act as a carrier of iron from the cells.	Iron	204-208	transferrin	Rattus norvegicus	22-33
7386413-5	1980	In rats fed the iron-deficient diet containing OCS (D + S group), all hematological values, tissue mineral contents with the exception of liver zinc levels, and liver tryptophan pyrrolase and kidney alkaline phosphatase activities were lowered, compared to the N or N + S group.	Iron	16-20	tryptophan 2,3-dioxygenase	Rattus norvegicus	167-187
6446325-0	1980	Transferrin-bipyridine iron transfer mediated by haemoproteins.	Iron	23-27	transferrin	Homo sapiens	0-11
7398651-0	1980	Uptake of iron from transferrin by isolated rat-liver mitochondria mediated by phosphate compounds.	Iron	10-14	transferrin	Rattus norvegicus	20-31
7398651-2	1980	Isolated rat-liver mitochondria accumulate iron from transferrin at neutral pH by a mechanism which is markedly stimulated by small-molecular-weight polyphosphate compounds.	Iron	43-47	transferrin	Rattus norvegicus	53-64
7398651-11	1980	The results suggest that iron is mobilized from transferrin by the polyphosphate compounds outside the mitochondria in a subsequent reaction.	Iron	25-29	transferrin	Rattus norvegicus	48-59
6769499-0	1980	The kinetics of iron release from human transferrin by EDTA.	Iron	16-20	transferrin	Homo sapiens	40-51
6769499-2	1980	The kinetics of iron release from diferric human transferrin by EDTA at pH 7.4 and 37 degrees C has been studied.	Iron	16-20	transferrin	Homo sapiens	49-60
6769499-7	1980	For the simple electrolyte ions studied, the rate of iron release from diferric-transferrin increases in accordance with the lyotropic series: SO4 2- less than HCO-2 less than Cl- less than ClO4- and Na+ less than Li+.	Iron	53-57	transferrin	Homo sapiens	80-91
6770907-2	1980	Complete and sequential iron saturation and desaturation of the lactotransferrin.	Iron	24-28	lactotransferrin	Homo sapiens	64-80
7371472-0	1980	A non-transferrin-bound serum iron in idiopathic hemochromatosis.	Iron	30-34	transferrin	Homo sapiens	6-17
7371472-6	1980	The majority of the non-transferrin-bound iron is of low molecular weight and is not bound to albumin.	Iron	42-46	transferrin	Homo sapiens	24-35
6251349-3	1980	Unsaturated fatty acids markedly enhanced the reduction of ferric cytochrome c by ferrous iron.	Iron	82-94	cytochrome c, somatic	Homo sapiens	66-78
7378318-3	1980	In control tissue the transferrin fraction contains 25%, ferritin 50% and haemprotein and haemosiderin 10--15% each, of the total iron.	Iron	130-134	transferrin	Homo sapiens	22-33
6248093-3	1980	Whole-blood iron transferrin levels were more variable, and were significantly raised only in patients with marrow failure.	Iron	12-16	transferrin	Homo sapiens	17-28
7359003-8	1980	Iron supplemented supernatants retaining potent lymphokine activity did not inhibit fungal growth.	Iron	0-4	interleukin 2	Homo sapiens	48-58
6153281-1	1980	It has been postulated that the transplacental passage of maternal iron to the developing fetus requires binding of maternal transferrin to the trophoblast.	Iron	67-71	transferrin	Homo sapiens	125-136
6153281-5	1980	These findings suggest that placental iron transport is initiated by uptake of maternal transferrin iron to specific trophoblast binding sites.	Iron	38-42	transferrin	Homo sapiens	88-99
6153281-5	1980	These findings suggest that placental iron transport is initiated by uptake of maternal transferrin iron to specific trophoblast binding sites.	Iron	100-104	transferrin	Homo sapiens	88-99
6154924-4	1980	Its affinity for iron is less and its molecular weight is greater than the one of transferrin.	Iron	17-21	transferrin	Homo sapiens	82-93
7357090-2	1980	When reticulocyte-rich red cells were incubated in vitro with doubly (59Fe, 125I) labeled transferrin, b/b cells demonstrated a significantly higher uptake of transferrin (164% of control at 60 min), and a significantly lower uptake of iron (21% of control at 60 min) than control cells.	Iron	236-240	transferrin	Rattus norvegicus	90-101
7357090-5	1980	These findings suggest a defect in the delivery of iron to the b/b reticulocyte, which is distal to the binding of transferrin to its cell surface receptor.	Iron	51-55	transferrin	Rattus norvegicus	115-126
6244848-10	1980	These observations demonstrate that these ligands compete for a binding site at or close to the heme iron of myeloperoxidase.	Iron	101-105	myeloperoxidase	Homo sapiens	109-124
6769468-5	1980	Transferrin concentration showed a significant negative correlation with serum Fe and percentage saturation of transferrin values.	Iron	79-81	transferrin	Homo sapiens	0-11
7396826-0	1980	The distribution of iron between the metal-binding sites of transferrin human serum.	Iron	20-24	transferrin	Homo sapiens	60-71
7396826-3	1980	Acta 453, 250--256] method of polyacrylamide-gel electrophoresis in buffer containing 6 M-urea was used to determine the distribution of iron between the N-terminal and C-terminal iron-binding sites of transferrin in human serum.	Iron	137-141	transferrin	Homo sapiens	202-213
7396826-3	1980	Acta 453, 250--256] method of polyacrylamide-gel electrophoresis in buffer containing 6 M-urea was used to determine the distribution of iron between the N-terminal and C-terminal iron-binding sites of transferrin in human serum.	Iron	180-184	transferrin	Homo sapiens	202-213
6986442-7	1980	Preliminary data as well as overall results suggest that the absolute transferrin content and its pH-dependent saturation with iron are key factors invovled in the growth-inhibiting activity.	Iron	127-131	transferrin	Homo sapiens	70-81
7353288-1	1980	Serum iron is released from transferrin and reduced at pH 1.7 by treating serum with a 10 g/L ascorbic acid solution in 0.1 mol/L HCl.	Iron	6-10	transferrin	Homo sapiens	28-39
6244265-4	1980	The EPR spectrum of myeloperoxidase indicated that the enzyme contains both high-spin heme and non-heme iron.	Iron	104-108	myeloperoxidase	Homo sapiens	20-35
6244265-12	1980	Based on these results, we concluded that one of the two iron atoms in a myeloperoxidase molecule exists in a formyl-heme moiety similar to heme a and the other exists as a non-heme iron.	Iron	57-61	myeloperoxidase	Homo sapiens	73-88
6244265-12	1980	Based on these results, we concluded that one of the two iron atoms in a myeloperoxidase molecule exists in a formyl-heme moiety similar to heme a and the other exists as a non-heme iron.	Iron	182-186	myeloperoxidase	Homo sapiens	73-88
7350147-6	1980	These results demonstrate that the induction of transferrin synthesis in iron-deficient chicks is regulated directly by an increase in transferrin mRNA.	Iron	73-77	transferrin	Homo sapiens	48-59
7356640-0	1980	Preparation and characterization of an NH2-terminal fragment of human serum transferrin containing a single iron-binding site.	Iron	108-112	transferrin	Homo sapiens	76-87
7350147-6	1980	These results demonstrate that the induction of transferrin synthesis in iron-deficient chicks is regulated directly by an increase in transferrin mRNA.	Iron	73-77	transferrin	Homo sapiens	135-146
7350147-7	1980	The iron-mediated effects on transferrin also appear to be gene-specific since the rate of synthesis of serum albumin, the major secretory product of liver, was unaffected by any of the experimental conditions.	Iron	4-8	transferrin	Homo sapiens	29-40
7350147-8	1980	Furthermore, when iron stores were rapidly replenished by the administration of iron-saturated ferritin, both the rate of transferrin synthesis and the level of transferrin mRNA returned to control values with 2 to 3 days.	Iron	18-22	transferrin	Homo sapiens	122-133
7350147-8	1980	Furthermore, when iron stores were rapidly replenished by the administration of iron-saturated ferritin, both the rate of transferrin synthesis and the level of transferrin mRNA returned to control values with 2 to 3 days.	Iron	18-22	transferrin	Homo sapiens	161-172
7356025-0	1980	A physiological model for hepatic metabolism of transferrin-bound iron.	Iron	66-70	transferrin	Rattus norvegicus	48-59
6278968-5	1980	Current concepts for the potential role of trophoblast Fc gamma and transferrin receptors in the mechanisms of transplacental passage of IgG and iron, respectively, from mother to fetus are illustrated and discussed.	Iron	145-149	transferrin	Homo sapiens	68-79
495547-0	1979	Relationship between hemoglobin concentration and transferrin saturation in iron-sufficient infants.	Iron	76-80	transferrin	Homo sapiens	50-61
6968022-3	1980	The addition of splenic macrophage-enriched preparations from either FBL-3-immune or normal mice suppressed the cytotoxic response of immune spleen cells treated with carbonyl iron and magnet.	Iron	176-180	F-box and leucine-rich repeat protein 2	Mus musculus	69-74
6968022-5	1980	The suppressed cell-mediated cytotoxic response against FBL-3 cells by immune spleen cells was augmented by the addition of indomethacin to the culture medium, and this augmentation with indomethacin was greatly decreased by depletion of phagocytic cells from the immune spleen by treatment with carbonyl iron and magnet.	Iron	305-309	F-box and leucine-rich repeat protein 2	Mus musculus	56-61
6255455-1	1980	In primate pregnancy, fetal iron is derived from maternal transferrin; however, the mechanisms by which iron is taken up by the human placenta have not yet been established.	Iron	28-32	transferrin	Homo sapiens	58-69
6255455-8	1980	These findings suggest that placental iron transport is predicated by binding of transferrin to specific receptors on trophoblast.	Iron	38-42	transferrin	Homo sapiens	81-92
7356552-1	1980	We describe a radiochemical method for measuring ferrochelatase activity in the in vitro incorporation of iron into mesoporphyrin-IX to form mesoheme.	Iron	106-110	ferrochelatase	Rattus norvegicus	49-63
7216229-3	1980	The three transferrin bands seen in homozygotes (double bands for heterozygotes) probably represent different degrees of iron saturation.	Iron	121-125	transferrin	Homo sapiens	10-21
227471-2	1979	The ability of a range of homologous transferrin-like proteins to donate iron to pieces of human duodenal mucosa, was examined with an in vitro incubation technique.	Iron	73-77	transferrin	Homo sapiens	37-48
227471-3	1979	In contrast to serum transferrin and ovotransferrin, only lactotransferrin was able to yield its iron to intestinal tissue, but in an autologous system this protein was unable to donate iron to human reticulocyte preparations.	Iron	97-101	lactotransferrin	Homo sapiens	58-74
495547-2	1979	In young infants whose serum ferritin values indicated ample storage iron, the concentration of hemoglobin was found to bear a significant relationship to the degree of iron saturation of transferrin.	Iron	69-73	transferrin	Homo sapiens	188-199
495547-2	1979	In young infants whose serum ferritin values indicated ample storage iron, the concentration of hemoglobin was found to bear a significant relationship to the degree of iron saturation of transferrin.	Iron	169-173	transferrin	Homo sapiens	188-199
42443-0	1979	Studies on the mechanism of iron release from transferrin.	Iron	28-32	transferrin	Homo sapiens	46-57
42443-4	1979	Different rates of iron release were obtained with the different proteins, greatest with human transferrin and least with lactoferrin.	Iron	19-23	transferrin	Homo sapiens	95-106
542335-0	1979	[Pathogenesis of a change in blood plasma transferrin saturation with iron under the influence of pyrogens].	Iron	70-74	transferrin	Homo sapiens	42-53
291949-2	1979	The increase of URO synthase activity was a linear function of erythropoietin concentration in the culture medium and was proportional to the extent of heme synthesis as determined by 55Fe incorporation into heme.	Iron	186-188	hydroxymethylbilane synthase	Homo sapiens	16-28
229912-0	1979	Preparation and partial characterization of iron-sulfur, iron-selenium, and iron-tellurium complexes of bovine serum albumin.	Iron	44-48	albumin	Homo sapiens	111-124
229912-0	1979	Preparation and partial characterization of iron-sulfur, iron-selenium, and iron-tellurium complexes of bovine serum albumin.	Iron	57-61	albumin	Homo sapiens	111-124
229912-1	1979	An artificial Fe-S* protein was prepared by the reaction of bovine serum albumin with FeSO4 and Na2S or with a synthetic Fe-S*-1,4-butanenedithiol complex.	Iron	14-18	albumin	Homo sapiens	67-80
229912-10	1979	The iron-selenium and iron-tellurium derivatives of the bovine serum albumin were prepared and partially characterized by optical absorption and electron paramagnetic resonsnace spectroscopies.	Iron	4-8	albumin	Homo sapiens	63-76
229912-10	1979	The iron-selenium and iron-tellurium derivatives of the bovine serum albumin were prepared and partially characterized by optical absorption and electron paramagnetic resonsnace spectroscopies.	Iron	22-26	albumin	Homo sapiens	63-76
42443-7	1979	It is concluded that iron release from transferrin under the conditions of these experiments involves an initial interaction between H+ and the iron-transferrin complex followed by release of the iron under the action of the mediator.	Iron	21-25	transferrin	Homo sapiens	39-50
42443-7	1979	It is concluded that iron release from transferrin under the conditions of these experiments involves an initial interaction between H+ and the iron-transferrin complex followed by release of the iron under the action of the mediator.	Iron	21-25	transferrin	Homo sapiens	149-160
42443-7	1979	It is concluded that iron release from transferrin under the conditions of these experiments involves an initial interaction between H+ and the iron-transferrin complex followed by release of the iron under the action of the mediator.	Iron	144-148	transferrin	Homo sapiens	39-50
42443-7	1979	It is concluded that iron release from transferrin under the conditions of these experiments involves an initial interaction between H+ and the iron-transferrin complex followed by release of the iron under the action of the mediator.	Iron	144-148	transferrin	Homo sapiens	149-160
42443-7	1979	It is concluded that iron release from transferrin under the conditions of these experiments involves an initial interaction between H+ and the iron-transferrin complex followed by release of the iron under the action of the mediator.	Iron	144-148	transferrin	Homo sapiens	39-50
42443-7	1979	It is concluded that iron release from transferrin under the conditions of these experiments involves an initial interaction between H+ and the iron-transferrin complex followed by release of the iron under the action of the mediator.	Iron	144-148	transferrin	Homo sapiens	149-160
519812-0	1979	A model system of cytochrome P-450: hydroxylation of aniline by iron- or hemin-thiol compound systems.	Iron	64-68	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-34
479164-0	1979	The reduction and release of iron from Fe3+ .transferrin.CO3(2-).	Iron	29-33	transferrin	Homo sapiens	45-56
314815-2	1979	Iron-free phosvitin (chicken and frog) or alpha sl-casein (cow) was dialyzed against the iron(III) chelates of nitrilotriacetate (NTA), )ethylenedinitrilo)tetraacetate (EDTA), or citrate.	Iron	0-4	Casein kinase II subunit beta	Gallus gallus	10-19
504966-0	1979	Serum iron and transferrin saturation in women with special reference to women with low transferrin saturation.	Iron	6-10	transferrin	Homo sapiens	88-99
496901-0	1979	The mechanism of hepatic iron uptake from native and denatured transferrin and its subcellular metabolism in the liver cell.	Iron	25-29	transferrin	Rattus norvegicus	63-74
116362-3	1979	A good correlation between serum transferrin and total iron-binding capacity values was found.	Iron	55-59	transferrin	Homo sapiens	33-44
496901-9	1979	The study suggests that hepatic iron uptake from native transferrin does not involve endocytosis.	Iron	32-36	transferrin	Rattus norvegicus	56-67
220262-1	1979	Two binuclear iron-sulfur clusters (designated S-1 and S-2) are present in succinate dehydrogenase in approximately equal concentration to that of flavin.	Iron	14-18	proteasome 26S subunit, non-ATPase 1	Homo sapiens	47-50
220262-1	1979	Two binuclear iron-sulfur clusters (designated S-1 and S-2) are present in succinate dehydrogenase in approximately equal concentration to that of flavin.	Iron	14-18	ribosomal protein S2	Homo sapiens	55-58
35223-8	1979	At pH 1.0 there is a different high-spin form of cytochrome c which has an estimated iron out-of-plane distance of approximately 0.46 A.	Iron	85-89	cytochrome c, somatic	Homo sapiens	49-61
444649-0	1979	Distribution of iron between the binding sites of transferrin in serum: methods and results in normal human subjects.	Iron	16-20	transferrin	Homo sapiens	50-61
444649-1	1979	When it is incompletely saturated with iron, transferrin may exist in four molecular forms: apotransferrin, monoferric (A) transferrin (with iron occupying only the A site of the protein), monoferric (B) transferrin, and diferric transferrin.	Iron	39-43	transferrin	Homo sapiens	45-56
444649-1	1979	When it is incompletely saturated with iron, transferrin may exist in four molecular forms: apotransferrin, monoferric (A) transferrin (with iron occupying only the A site of the protein), monoferric (B) transferrin, and diferric transferrin.	Iron	141-145	transferrin	Homo sapiens	45-56
444649-3	1979	The distribution of iron between the binding sites of transferrin is neither random nor determined by the relative binding strengths of transferrin"s two sites.	Iron	20-24	transferrin	Homo sapiens	54-65
444649-3	1979	The distribution of iron between the binding sites of transferrin is neither random nor determined by the relative binding strengths of transferrin"s two sites.	Iron	20-24	transferrin	Homo sapiens	136-147
465371-1	1979	The major iron-bearing cytosol components of human reticulocytes identified after incubation with 59 Fe-125I-transferrin have been studied further.	Iron	10-14	transferrin	Homo sapiens	109-120
465371-5	1979	Restriction of iron uptake by reticulocytes using both p-hydroxymercuribenzoate inhibition of uptake and incubation with progressively lower saturations of iron-transferrin gave linearly related incorporation of 59Fe into ferritin and haemoglobin at all levels of iron uptake, thus negating the concept of ferritin as an "overspill" form of reticulocyte iron.	Iron	15-19	transferrin	Homo sapiens	161-172
465371-5	1979	Restriction of iron uptake by reticulocytes using both p-hydroxymercuribenzoate inhibition of uptake and incubation with progressively lower saturations of iron-transferrin gave linearly related incorporation of 59Fe into ferritin and haemoglobin at all levels of iron uptake, thus negating the concept of ferritin as an "overspill" form of reticulocyte iron.	Iron	156-160	transferrin	Homo sapiens	161-172
465371-5	1979	Restriction of iron uptake by reticulocytes using both p-hydroxymercuribenzoate inhibition of uptake and incubation with progressively lower saturations of iron-transferrin gave linearly related incorporation of 59Fe into ferritin and haemoglobin at all levels of iron uptake, thus negating the concept of ferritin as an "overspill" form of reticulocyte iron.	Iron	156-160	transferrin	Homo sapiens	161-172
465371-5	1979	Restriction of iron uptake by reticulocytes using both p-hydroxymercuribenzoate inhibition of uptake and incubation with progressively lower saturations of iron-transferrin gave linearly related incorporation of 59Fe into ferritin and haemoglobin at all levels of iron uptake, thus negating the concept of ferritin as an "overspill" form of reticulocyte iron.	Iron	156-160	transferrin	Homo sapiens	161-172
444583-0	1979	The rate limiting step in the reticulocyte uptake of transferrin and transferrin iron.	Iron	81-85	transferrin	Homo sapiens	69-80
444583-2	1979	Reticulocytes incubated in an isotonic NaCl saline medium containing glucose, glutamine and amino acids, were able to detach both iron atoms from all the transferrin incorporated by them.	Iron	130-134	transferrin	Homo sapiens	154-165
444583-6	1979	At least 94% of the iodinated transferrin was capable of donating its iron to the reticulocytes.	Iron	70-74	transferrin	Homo sapiens	30-41
429862-0	1979	Transferrin binding and iron transport in iron-deficient and iron-replete rat reticulocytes.	Iron	42-46	transferrin	Rattus norvegicus	0-11
218639-1	1979	Experiments demonstrating the existence of receptors for iron-saturated transferrin on both B and T lymphoblastoid cell lines of human origin are described.	Iron	57-61	transferrin	Homo sapiens	72-83
429862-0	1979	Transferrin binding and iron transport in iron-deficient and iron-replete rat reticulocytes.	Iron	42-46	transferrin	Rattus norvegicus	0-11
464397-10	1979	In contrast to conalbumin, thermograms of serotransferrin solutions partially saturated with ferric ions exhibit only the peaks corresponding to those obtained on separate DSC scans of iron-free and iron serotransferrin, respectively.	Iron	185-189	transferrin	Homo sapiens	42-57
420819-5	1979	The capacity of the oxidation agents to serve as oxygen donors in cytochrome P-450 dependent steroid hydroxylation is probably dependent upon several factors such as the tendency of iodosyl compounds to associate, which decreases coordination with the heme iron, the presence of bulky substituents in the 2 position (decreases association), and the presence of electron-withdrawing substituents (tends to decrease coordination with the heme iron).	Iron	257-261	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
420819-5	1979	The capacity of the oxidation agents to serve as oxygen donors in cytochrome P-450 dependent steroid hydroxylation is probably dependent upon several factors such as the tendency of iodosyl compounds to associate, which decreases coordination with the heme iron, the presence of bulky substituents in the 2 position (decreases association), and the presence of electron-withdrawing substituents (tends to decrease coordination with the heme iron).	Iron	441-445	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
37515-2	1979	That the distribution of transferrin is limited to the materno-foetal interface supports the hypothesis that binding of maternal transferrin to trophoblast receptors is involved in the process of iron transport to the foetus.	Iron	196-200	transferrin	Homo sapiens	25-36
37515-2	1979	That the distribution of transferrin is limited to the materno-foetal interface supports the hypothesis that binding of maternal transferrin to trophoblast receptors is involved in the process of iron transport to the foetus.	Iron	196-200	transferrin	Homo sapiens	129-140
37515-5	1979	These findings suggest that transferrin receptors may play important biological roles in addition to that of iron transport from mother to foetus.	Iron	109-113	transferrin	Homo sapiens	28-39
464397-1	1979	The thermal denaturation of iron-free and iron human serotransferrin has been studied by differential scanning calorimetry.	Iron	42-46	transferrin	Homo sapiens	53-68
464397-10	1979	In contrast to conalbumin, thermograms of serotransferrin solutions partially saturated with ferric ions exhibit only the peaks corresponding to those obtained on separate DSC scans of iron-free and iron serotransferrin, respectively.	Iron	199-203	transferrin	Homo sapiens	42-57
424657-8	1979	The distribution of copper in the supernatant was changed due to a simultaneous administration of iron; the amount of copper bound in the transferrin fraction decreased in favor of the metallothionein fraction and another copper binding fraction was eluted between the transferrin and the metallothionein fraction.	Iron	98-102	transferrin	Rattus norvegicus	138-149
424657-12	1979	The results suggest that the affinity of copper to two mucosal iron binding proteins, transferrin and metallothionein, is at least partly responsible for the inhibitory effect of copper on iron absorption in iron deficiency.	Iron	63-67	transferrin	Rattus norvegicus	86-97
424657-12	1979	The results suggest that the affinity of copper to two mucosal iron binding proteins, transferrin and metallothionein, is at least partly responsible for the inhibitory effect of copper on iron absorption in iron deficiency.	Iron	189-193	transferrin	Rattus norvegicus	86-97
429836-0	1979	In vivo evidence for the functional heterogeneity of transferrin-bound iron.	Iron	71-75	transferrin	Rattus norvegicus	53-64
215100-0	1979	Iron and the liver: subcellular distribution of iron and decreased microsomal cytochrome P-450 in livers of iron-loaded rats.	Iron	0-4	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	78-94
229673-1	1979	Spin state transitions of membrane-bound cytochrome P-450 were investigated by difference spectrophotometry using the "D"-charge transfer absorbance band at 645 nm as a measure of the amount of hemin iron present in the 5-coordinated state.	Iron	200-204	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	41-57
517008-2	1979	The calculations show that the unusual spectral properties of cytochrome P-450 are very sensitive to the iron-sulfur bond distance.	Iron	105-109	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-78
517008-3	1979	It is suggested from these calculations that for the conversion of cytochrome P-450 to cytochrome P-420 an increase of the iron-sulfur bond distance of only about 0.2 A is sufficient.	Iron	123-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	67-83
517010-3	1979	The two maxima of the nonequilibrium form of cytochrome P-450 without substrate in the visible absorption spectrum (alpha-band, beta-band) and the ratio of their intensities indicate the low-spin character of the heme iron.	Iron	218-222	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-61
215100-0	1979	Iron and the liver: subcellular distribution of iron and decreased microsomal cytochrome P-450 in livers of iron-loaded rats.	Iron	108-112	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	78-94
215100-7	1979	Cytochrome P-450 and total heme concentrations were decreased 40% to 50% in microsomes isolated from iron-loaded livers.	Iron	101-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
711859-0	1978	Iron uptake from rat plasma transferrin by rat reticulocytes.	Iron	0-4	transferrin	Rattus norvegicus	28-39
751406-0	1978	The iron binding and releasing functions of the transferrin with special reference to rat isotransferrins.	Iron	4-8	transferrin	Rattus norvegicus	48-59
700326-1	1978	Hepatic iron uptake from transferrin has been studied in 7 patients with treated hemochromatosis.	Iron	8-12	transferrin	Homo sapiens	25-36
700326-2	1978	When compared with a control group with similar serum iron and transferrin saturation the hemochromatotics had a significantly higher 4-hr iron uptake value.	Iron	139-143	transferrin	Homo sapiens	63-74
104124-2	1979	Chromium is transported in the body bound to transferrin, where it binds competitively with iron.	Iron	92-96	transferrin	Homo sapiens	45-56
104124-3	1979	Hemochromatosis is an iron storage disease in humans characterized by highly saturated transferrin levels and sometimes by diabetes.	Iron	22-26	transferrin	Homo sapiens	87-98
719174-0	1978	Differences between the binding sites for iron binding and release in human and rat transferrin.	Iron	42-46	transferrin	Rattus norvegicus	84-95
711859-3	1978	Reticulocyte uptake of diferric transferrin resulted in the removal of both iron atoms from the transferrin molecule.	Iron	76-80	transferrin	Rattus norvegicus	32-43
711859-3	1978	Reticulocyte uptake of diferric transferrin resulted in the removal of both iron atoms from the transferrin molecule.	Iron	76-80	transferrin	Rattus norvegicus	96-107
711859-5	1978	It is concluded that the two species of transferrin and their individual sites function similarly in their release of iron to tissue receptors.	Iron	118-122	transferrin	Rattus norvegicus	40-51
728460-0	1978	Iron uptake by Chang cells from transferrin, nitriloacetate and citrate complexes: the effects of iron-loading and chelation with desferrioxamine.	Iron	0-4	transferrin	Homo sapiens	32-43
83774-2	1978	In gel chromatography, paper electrophoresis and acetate cellulose electrophoresis it was demonstrated that the latent capacity for iron saturation is a feature of not only transferrin belonging to beta1 globulins, but also to some extent of albumins and alpha-globulins.	Iron	132-136	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	198-203
728460-1	1978	Iron uptake by Chang liver cells in culture is about thirty times as great when ferric nitriloacetate is used as a donor as when iron-transferrin is used.	Iron	0-4	transferrin	Homo sapiens	134-145
728460-3	1978	Most of the intracellular iron derived from transferrin is found in the supernatant after 20 000 x g centrifugation of the cell homogenate for 40 min: about half of this is in the form of ferritin.	Iron	26-30	transferrin	Homo sapiens	44-55
30806-0	1978	Analysis of the iron-binding sites of transferrin by isoelectric focussing.	Iron	16-20	transferrin	Homo sapiens	38-49
708645-3	1978	In contrast, less than 1.0 mumol/l of transferrin bound iron was removed when subjected to the same procedures.	Iron	56-60	transferrin	Homo sapiens	38-49
708645-6	1978	These findings indicate that non-specific iron is a chelatable compound which is readily available for transferrin binding.	Iron	42-46	transferrin	Homo sapiens	103-114
30806-4	1978	Four transferrin forms, transferrin, transferrin(Fe) (A-site), transferrin(Fe) (B-site) and transferrin(2Fe) could be separated on flat bed gels by isoelectric focussing.	Iron	49-51	transferrin	Homo sapiens	5-16
687622-0	1978	Binding sites of iron transferrin on rat reticulocytes.	Iron	17-21	transferrin	Rattus norvegicus	22-33
30489-0	1978	The effect of acid pH and citrate on the release and exchange of iron on rat transferrin.	Iron	65-69	transferrin	Rattus norvegicus	77-88
30489-1	1978	The effect of acid pH and citrate on the exchange of iron between binding sites of rat transferrin has been studied.	Iron	53-57	transferrin	Rattus norvegicus	87-98
30489-2	1978	In the absence of citrate, diferric transferrin shows stepwise loss of iron atoms with the first atom of iron released at approximately pH 5.2.	Iron	71-75	transferrin	Rattus norvegicus	36-47
30489-4	1978	Iron dissociation from monoferric transferrin at acid pH, with or without citrate, is a random process.	Iron	0-4	transferrin	Rattus norvegicus	34-45
30489-5	1978	At pH 7.4, randomization of iron on transferrin takes from 3 to 6 h in the presence of millimolar concentrations of citrate.	Iron	28-32	transferrin	Rattus norvegicus	36-47
568516-2	1978	After removal of the agent a wave of transferrin-dependent iron uptake was observed only in early G(1).	Iron	59-63	transferrin	Homo sapiens	37-48
684293-9	1978	In anemia due to protein deficiency the typical increase of 59Fe incorporation into the fraction of mucosal transferrin--usually occuring in iron deficiency--could not be observed.	Iron	141-145	transferrin	Rattus norvegicus	108-119
684293-11	1978	Moreover a decrease of iron absorption is observed, which is associated with a decreased 59Fe ratio of transferrin/ferritin-fraction.	Iron	23-27	transferrin	Rattus norvegicus	103-114
700103-0	1978	Differential effects of metal-binding agents on the uptake of iron from transferrin by isolated rat liver mitochondria.	Iron	62-66	transferrin	Rattus norvegicus	72-83
687622-3	1978	In the process of iron uptake by precursors of the erythrocytes probably more than one membrane component is involved; besides the specific transferrin receptor, another membrane component with a high iron activity after incubation with 59Fe can be isolated.	Iron	18-22	transferrin	Rattus norvegicus	140-151
687622-7	1978	Incubation of reticulocytes with Fab fragments of an antibody against the membrane receptor for transferrin causes a concentration-dependent decrease in transferrin binding and iron uptake.	Iron	177-181	transferrin	Rattus norvegicus	96-107
687622-11	1978	Intact immature red cells are necessary for specific binding of transferrin with the receptor followed by iron uptake.	Iron	106-110	transferrin	Rattus norvegicus	64-75
32928-8	1978	This fact confirms the interaction of alcohols HO-groups with heme iron of cytochrome P-450.	Iron	67-71	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	75-91
698186-0	1978	Iron exchange between ferritin and transferrin in vitro.	Iron	0-4	transferrin	Homo sapiens	35-46
100104-13	1978	The distribution of iron in human serum transferrin partially saturated with various iron donors was examined by electrophoresis in urea/polyacrylamide gels and the two possible monoferric forms were unequivocally identified.	Iron	20-24	transferrin	Homo sapiens	40-51
100104-17	1978	The distribution of iron on transferrin in human plasma was determined.	Iron	20-24	transferrin	Homo sapiens	28-39
698124-3	1978	Specific incorporation of iron into feritin from a perfusate of normal transferrin iron saturation was enhanced in nutritional iron deficiency as compared to controls after 5 h of perfusion but not after 1 h, suggesting that increased uptake of iron from the perfusate may play a role in stimulating hepatic ferritin synthesis and assembly.	Iron	26-30	transferrin	Rattus norvegicus	71-82
698124-3	1978	Specific incorporation of iron into feritin from a perfusate of normal transferrin iron saturation was enhanced in nutritional iron deficiency as compared to controls after 5 h of perfusion but not after 1 h, suggesting that increased uptake of iron from the perfusate may play a role in stimulating hepatic ferritin synthesis and assembly.	Iron	83-87	transferrin	Rattus norvegicus	71-82
698124-3	1978	Specific incorporation of iron into feritin from a perfusate of normal transferrin iron saturation was enhanced in nutritional iron deficiency as compared to controls after 5 h of perfusion but not after 1 h, suggesting that increased uptake of iron from the perfusate may play a role in stimulating hepatic ferritin synthesis and assembly.	Iron	83-87	transferrin	Rattus norvegicus	71-82
698124-5	1978	In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion.	Iron	26-30	transferrin	Rattus norvegicus	117-128
698124-5	1978	In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion.	Iron	45-49	transferrin	Rattus norvegicus	117-128
698124-5	1978	In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion.	Iron	45-49	transferrin	Rattus norvegicus	179-190
698124-5	1978	In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion.	Iron	45-49	transferrin	Rattus norvegicus	117-128
698124-5	1978	In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion.	Iron	45-49	transferrin	Rattus norvegicus	179-190
698124-5	1978	In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion.	Iron	45-49	transferrin	Rattus norvegicus	117-128
698124-5	1978	In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion.	Iron	45-49	transferrin	Rattus norvegicus	179-190
698124-6	1978	A significant positive correlation was found between the hepatic total and ferritin iron uptake and the transferrin synthetic rate measured in the same liver.	Iron	84-88	transferrin	Rattus norvegicus	104-115
698124-7	1978	It is proposed that in the liver the negative feedback of iron supply on transferrin synthesis may be linked with a positive feedback on ferritin synthesis.	Iron	58-62	transferrin	Rattus norvegicus	73-84
698124-8	1978	The time-course of these reciprocal responses suggests a role for hepatic ferritin and/or a component of the non-haem, non-ferritin iron pool in the regulation of transferrin synthesis.	Iron	132-136	transferrin	Rattus norvegicus	163-174
698186-1	1978	The transfer of iron between horse spleen [55Fe]ferritin and human apotransferrin or [59Fe]transferrin in homogeneous solution was investigated.	Iron	16-20	transferrin	Homo sapiens	70-81
698186-6	1978	Citrate-mediated transfer of iron from ferritin to apotransferrin is first order with respect to ferritin, zero order with respect to transferrin, and has a complex dependence upon citrate concentration.	Iron	29-33	transferrin	Homo sapiens	54-65
698186-10	1978	One possible explanation for these observations is that iron from the core of ferritin is in equilibrium with iron near the outer surface of the protein, where the metal would be available to transferrin.	Iron	56-60	transferrin	Homo sapiens	192-203
677335-0	1978	Effect of transferrin saturation on iron delivery in rats.	Iron	36-40	transferrin	Rattus norvegicus	10-21
677335-1	1978	Studies were carried out in rats to evaluate the release of iron from monoferric and diferric transferrin.	Iron	60-64	transferrin	Rattus norvegicus	94-105
677335-4	1978	In all three groups there was a greater in vivo uptake of iron from diferric transferrin by all tissues monitored.	Iron	58-62	transferrin	Rattus norvegicus	77-88
677335-5	1978	Though the amount varied in different animals, the ratio of uptake between diferric and monoferric transferrin iron varied between 1.56 and 2.10 in the erythron and between 2.38 and 2.65 in the liver.	Iron	111-115	transferrin	Rattus norvegicus	99-110
677335-6	1978	These studies indicate that changes in transferrin saturation, by changing the proportion of monoferric to diferric transferrin iron, changed the amount of iron released to tissues.	Iron	128-132	transferrin	Rattus norvegicus	39-50
698186-10	1978	One possible explanation for these observations is that iron from the core of ferritin is in equilibrium with iron near the outer surface of the protein, where the metal would be available to transferrin.	Iron	110-114	transferrin	Homo sapiens	192-203
677335-6	1978	These studies indicate that changes in transferrin saturation, by changing the proportion of monoferric to diferric transferrin iron, changed the amount of iron released to tissues.	Iron	128-132	transferrin	Rattus norvegicus	116-127
677335-6	1978	These studies indicate that changes in transferrin saturation, by changing the proportion of monoferric to diferric transferrin iron, changed the amount of iron released to tissues.	Iron	156-160	transferrin	Rattus norvegicus	39-50
677335-6	1978	These studies indicate that changes in transferrin saturation, by changing the proportion of monoferric to diferric transferrin iron, changed the amount of iron released to tissues.	Iron	156-160	transferrin	Rattus norvegicus	116-127
258165-6	1978	The nature of the low-molecular-weight iron complex which serves to transfer storage iron to transferrin and to supply iron for intracellular use remains to be established.	Iron	39-43	transferrin	Homo sapiens	93-104
30022-2	1978	Oxidation of bivalent iron and manganese is accomplished by the simultaneous action of catalase and hydrogen peroxide produced in the respiratory chain in the course of oxidation of organic substances.	Iron	22-26	catalase	Homo sapiens	87-95
149016-0	1978	Down syndrome - transferrin parallels plasma iron changes.	Iron	45-49	transferrin	Homo sapiens	16-27
149016-2	1978	In all these groups of patients, known to have significantly lowered plasma iron levels, the transferrin levels were found to be decreased with respect to the control group.	Iron	76-80	transferrin	Homo sapiens	93-104
258165-6	1978	The nature of the low-molecular-weight iron complex which serves to transfer storage iron to transferrin and to supply iron for intracellular use remains to be established.	Iron	85-89	transferrin	Homo sapiens	93-104
258165-6	1978	The nature of the low-molecular-weight iron complex which serves to transfer storage iron to transferrin and to supply iron for intracellular use remains to be established.	Iron	85-89	transferrin	Homo sapiens	93-104
208637-0	1978	Studies on the utilization of ferritin iron in the ferrochelatase reaction of isolated rat liver mitochondria.	Iron	39-43	ferrochelatase	Rattus norvegicus	51-65
658173-1	1978	Because of varying iron--transferrin concentrations in different serum samples, and varying test serum portions within the culture, variations of the radioiron--transferrin/total iron--transferrin ratio are inevitable, when serum erythropoietin (Ep) concentrations are measured using the fetal mouse liver cell assay.	Iron	155-159	transferrin	Homo sapiens	161-172
208637-1	1978	The utilization of ferritin as a source of iron for the ferrochelatase reaction has been studied in isolated rat liver mitochondria.	Iron	43-47	ferrochelatase	Rattus norvegicus	56-70
208637-3	1978	It was found that isolated rat liver mitochondria utilized ferritin as a source of iron for the ferrochelatase reaction in the presence of succinate plus FMN (or FAD).	Iron	83-87	ferrochelatase	Rattus norvegicus	96-110
656461-5	1978	This suggests that anhydride leghemoglobin has a conformation with a covalent attachment via propionic acid side chain to lysine-57 and the sixth coordination position of the heme iron occupied by the distal histidine at position 61.	Iron	180-184	leghemoglobin A	Glycine max	29-42
638119-6	1978	Fe supplementation increased the haemoglobin, serum Fe and percentage saturation of transferrin and reduced the unsaturated Fe-binding capacity significantly compared to corresponding values for the controls.	Iron	0-2	transferrin	Homo sapiens	84-95
658173-1	1978	Because of varying iron--transferrin concentrations in different serum samples, and varying test serum portions within the culture, variations of the radioiron--transferrin/total iron--transferrin ratio are inevitable, when serum erythropoietin (Ep) concentrations are measured using the fetal mouse liver cell assay.	Iron	155-159	transferrin	Homo sapiens	161-172
274740-4	1978	It was demonstrated that diferric transferrin had a greater rate of iron turnover but that the distribution between erythroid and non-erythroid tissues was unchanged.	Iron	68-72	transferrin	Homo sapiens	34-45
646825-2	1978	The electrophoretically fast (F) and slow (S) fragments obtained by tryptic cleavage of bovine iron-saturated transferrin differed in carbohydrate content and peptide "maps".	Iron	95-99	serotransferrin	Bos taurus	110-121
646825-8	1978	Bovine transferrin could donate iron to rabbit reticulocytes, but the monoferric fragments possessed little iron-donating ability.	Iron	32-36	serotransferrin	Bos taurus	7-18
657685-2	1978	The radioiron injected should be bound specifically to transferrin, and the measurement of plasma 59Fe activity should be corrected for variation in plasma iron concentration.	Iron	9-13	transferrin	Homo sapiens	55-66
660666-8	1978	Transferrin, the accessory factor in the SF condition, supplies iron for cells.	Iron	64-68	transferrin	Rattus norvegicus	0-11
210366-1	1978	The concentration of iron (III)-transferrin (IT) in whole blood and serum, along with another high-spin (five unpaired electrons) iron complex (probably IT) accumulated by tumor tissue, was investigated by electron paramagnetic resonance (EPR) spectroscopy during the development of Murphy-Sturm rat lymphosarcoma.	Iron	21-25	transferrin	Rattus norvegicus	32-43
346612-1	1978	An immunoperoxidase staining technique was used for detecting three major iron-binding proteins (transferrin, ferritin, and lactoferrin) in routine histological paraffin sections of human tissue.	Iron	74-78	transferrin	Homo sapiens	97-108
204636-0	1978	Stoichiometric and site characteristics of the binding of iron to human transferrin.	Iron	58-62	transferrin	Homo sapiens	72-83
623907-4	1978	The second pathway, which was extracellular, could only be activated after saturation of the transferrin iron binding capacity, with the chelated iron excreted by the kidneys.	Iron	105-109	transferrin	Rattus norvegicus	93-104
623907-4	1978	The second pathway, which was extracellular, could only be activated after saturation of the transferrin iron binding capacity, with the chelated iron excreted by the kidneys.	Iron	146-150	transferrin	Rattus norvegicus	93-104
623907-6	1978	Further studies will be required in order to establish whether the enhancement in iron chelation obtained by the continuous infusion of DF in patients with complete saturation of circulating transferrin may or may not be related to the extracellular mechanism of iron chelation in hypertransfused rats.	Iron	82-86	transferrin	Homo sapiens	191-202
274740-5	1978	It was concluded that plasma iron turnover is dependent on the monoferric/diferric transferrin ratio in the plasma but that the internal distribution of iron is unaffected.	Iron	29-33	transferrin	Homo sapiens	83-94
23724-0	1978	Interaction of beta-lactoglobulin and cytochrome c: complex formation and iron reduction.	Iron	74-78	cytochrome c, somatic	Homo sapiens	38-50
23866-4	1978	One human transferrin iron binding site retains an ability to bind iron at somewhat acid pH but this property is not shared by rabbit transferrin.	Iron	22-26	transferrin	Homo sapiens	10-21
23866-4	1978	One human transferrin iron binding site retains an ability to bind iron at somewhat acid pH but this property is not shared by rabbit transferrin.	Iron	67-71	transferrin	Homo sapiens	10-21
99949-3	1978	These pure catalases induced, after injecting into guinea-pigs, anti-serums that react specifically with catalase and does not give any cross reaction with peroxidases and haemic iron containing compounds.	Iron	179-183	catalase	Homo sapiens	11-19
22345-0	1978	Factors affecting the adenosine triphosphate induced release of iron from transferrin.	Iron	64-68	transferrin	Homo sapiens	74-85
22345-1	1978	The release of iron from transferrin was investigated by incubating the diferric protein in the presence of potential iron-releasing agents.	Iron	15-19	transferrin	Homo sapiens	25-36
22345-1	1978	The release of iron from transferrin was investigated by incubating the diferric protein in the presence of potential iron-releasing agents.	Iron	118-122	transferrin	Homo sapiens	25-36
22345-6	1978	The rate of iron release rapidly increased as transferrin was titrated with HCl from pH 6.8 to 6.1 in the presence of 1 mM ATP and 160 mM NaCl at 20 degrees C. Iron release from transferrin without ATP was observed below pH 5.5.	Iron	12-16	transferrin	Homo sapiens	46-57
22345-6	1978	The rate of iron release rapidly increased as transferrin was titrated with HCl from pH 6.8 to 6.1 in the presence of 1 mM ATP and 160 mM NaCl at 20 degrees C. Iron release from transferrin without ATP was observed below pH 5.5.	Iron	12-16	transferrin	Homo sapiens	178-189
22345-6	1978	The rate of iron release rapidly increased as transferrin was titrated with HCl from pH 6.8 to 6.1 in the presence of 1 mM ATP and 160 mM NaCl at 20 degrees C. Iron release from transferrin without ATP was observed below pH 5.5.	Iron	160-164	transferrin	Homo sapiens	46-57
22345-6	1978	The rate of iron release rapidly increased as transferrin was titrated with HCl from pH 6.8 to 6.1 in the presence of 1 mM ATP and 160 mM NaCl at 20 degrees C. Iron release from transferrin without ATP was observed below pH 5.5.	Iron	160-164	transferrin	Homo sapiens	178-189
22345-7	1978	Ascorbate (10(-4) M) reduced Fe(III), but only after iron release from transferrin by a physiological concentration of ATP.	Iron	53-57	transferrin	Homo sapiens	71-82
22345-8	1978	A proposal for the mechanism of iron release from transferrin by ATP and the utilization of reduced iron by erythroid cells is described.	Iron	32-36	transferrin	Homo sapiens	50-61
22546-3	1978	In the presence of this compound, a specific iron-transferrin-anion complex is formed, as evidenced by the development of a characteristic red color.	Iron	45-49	transferrin	Homo sapiens	50-61
22546-7	1978	The pH dependence of iron dissociation from iron-transferrin-oxalate is also reported.	Iron	21-25	transferrin	Homo sapiens	49-60
101008-0	1978	Functional heterogeneity of transferrin-bound iron: iron uptake by cell suspensions from bone marrow and liver and by cell cultures of fibroblasts and lymphoblasts.	Iron	46-50	transferrin	Rattus norvegicus	28-39
101008-0	1978	Functional heterogeneity of transferrin-bound iron: iron uptake by cell suspensions from bone marrow and liver and by cell cultures of fibroblasts and lymphoblasts.	Iron	52-56	transferrin	Rattus norvegicus	28-39
101008-1	1978	According to the hypothesis of Fletcher and Huehns, functional differences exist between both iron-binding sites of transferrin.	Iron	94-98	transferrin	Rattus norvegicus	116-127
101008-4	1978	Iron transferrin preincubated with rat bone marrow cells donates less iron to rat bone marrow cells, Chinese hamster fibroblasts, human fibroblasts and human lymphoblasts than freshly prepared iron transferrin equal in iron and transferrin concentraion.	Iron	0-4	transferrin	Rattus norvegicus	5-16
101008-4	1978	Iron transferrin preincubated with rat bone marrow cells donates less iron to rat bone marrow cells, Chinese hamster fibroblasts, human fibroblasts and human lymphoblasts than freshly prepared iron transferrin equal in iron and transferrin concentraion.	Iron	70-74	transferrin	Rattus norvegicus	5-16
101008-4	1978	Iron transferrin preincubated with rat bone marrow cells donates less iron to rat bone marrow cells, Chinese hamster fibroblasts, human fibroblasts and human lymphoblasts than freshly prepared iron transferrin equal in iron and transferrin concentraion.	Iron	193-197	transferrin	Rattus norvegicus	5-16
101008-4	1978	Iron transferrin preincubated with rat bone marrow cells donates less iron to rat bone marrow cells, Chinese hamster fibroblasts, human fibroblasts and human lymphoblasts than freshly prepared iron transferrin equal in iron and transferrin concentraion.	Iron	193-197	transferrin	Rattus norvegicus	5-16
747324-6	1978	Lactoferrin and transferrin in the iron-free state were both susceptible to proteolysis, but the iron saturated forms were more resistant and tended to give rise to stable iron-binding fragments.	Iron	35-39	serotransferrin	Bos taurus	16-27
101008-5	1978	Rat liver parenchymal cells, however, take up more iron from preincubated than from freshly prepared iron transferrin.	Iron	51-55	transferrin	Rattus norvegicus	106-117
101008-5	1978	Rat liver parenchymal cells, however, take up more iron from preincubated than from freshly prepared iron transferrin.	Iron	101-105	transferrin	Rattus norvegicus	106-117
744358-0	1978	Metabolism of transferrin-bound iron by the liver: a study in vivo.	Iron	32-36	transferrin	Homo sapiens	14-25
367903-3	1978	The biological significance of hyposideremia may be presumed from the bacteriostatic potential of iron free transferrin, preventing adequate iron acquisition by multiplying microorganisms.	Iron	98-102	transferrin	Homo sapiens	108-119
367903-3	1978	The biological significance of hyposideremia may be presumed from the bacteriostatic potential of iron free transferrin, preventing adequate iron acquisition by multiplying microorganisms.	Iron	141-145	transferrin	Homo sapiens	108-119
594498-0	1977	Mucosal transferrin and ferritin factors in the regulation of iron absorption.	Iron	62-66	transferrin	Homo sapiens	8-19
622822-3	1978	Measurement of transferrin saturation showed that one-third of professional donors were quite severely iron deficient.	Iron	103-107	transferrin	Homo sapiens	15-26
594498-14	1977	Mucosal transferrin is responsible for the increase of absorption in iron deficiency while mucosal ferritin is responsible for the inhibition of iron absorption when the iron homeostasis recompensats.	Iron	69-73	transferrin	Homo sapiens	8-19
597313-0	1977	Rhodanese-iron protein association in bovine liver extracts.	Iron	10-14	thiosulfate sulfurtransferase	Bos taurus	0-9
597272-11	1977	Iron-free transferrin also had some antioxidant activity.	Iron	0-4	transferrin	Homo sapiens	10-21
922163-0	1977	Transferrin iron-binding sites.	Iron	12-16	transferrin	Homo sapiens	0-11
915001-6	1977	In the presence of 25 muM iron, protoporphyrin was detected in protoporphyria cell lines when the concentration of ALA in the medium reached 50 muM, but not in normal lines.	Iron	26-30	latexin	Homo sapiens	22-25
915001-6	1977	In the presence of 25 muM iron, protoporphyrin was detected in protoporphyria cell lines when the concentration of ALA in the medium reached 50 muM, but not in normal lines.	Iron	26-30	latexin	Homo sapiens	144-147
921926-0	1977	Energy transfer between terbium and iron bound to transferrin: reinvestigation of the distance between metal-binding sites.	Iron	36-40	transferrin	Homo sapiens	50-61
921926-1	1977	The addition of trivalent iron, gallium, and terbium ions to the metal binding sites of human transferrin has been investigated by fluorescence and spectrophotometric measurements.	Iron	26-30	transferrin	Homo sapiens	94-105
921926-3	1977	The subsequent addition of terbium leads to the binding of terbium ions to the vacant sites on monoferric transferrin molecules, and observations of the intensity of terbium fluorescence from such samples provides clear evidence of transfer of excitation energy from the terbium site to the iron site.	Iron	291-295	transferrin	Homo sapiens	106-117
410811-4	1977	Also, when bicarbonate was added to a solution of the iron-transferrin-EDTA complex (A515 = 0.45), within 2 min, the visible absorbance had decreased to A515 = 0.13.	Iron	54-58	transferrin	Homo sapiens	59-70
410811-5	1977	Slowly a new peak appeared (lambdamax = 470 nm), evidently the iron-transferrin-CO3 complex.	Iron	63-67	transferrin	Homo sapiens	68-79
410811-9	1977	It is clear that there is an intimate relationship between anions and the binding of iron chelates by transferrin.	Iron	85-89	transferrin	Homo sapiens	102-113
334441-0	1977	Regulation of cytochrome P-450-dependent microsomal drug-metabolizing enzymes by nickel, cobalt, and iron.	Iron	101-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-30
921348-0	1977	Transferrin iron uptake by human synovium.	Iron	12-16	transferrin	Homo sapiens	0-11
578539-2	1977	In these persons, the serum iron was ordered at the time of initial examination, and ranged from 212 to 237 microgram/dl with a transferrin saturation of 83% to 100%.	Iron	28-32	transferrin	Homo sapiens	128-139
921348-2	1977	The results show that transferrin iron is taken up by synovial macrophages.	Iron	34-38	transferrin	Homo sapiens	22-33
199115-1	1977	Electron spin resonance spectroscopy as a probe of the hemin iron of cytochrome P-450: the influence of buffer composition, alcohols, and nitrogenous ligands.	Iron	61-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-85
202245-8	1977	The presence of ferrochelatase was indicated by the incorporation of (55)Fe into proto- and haemato-haem identified by paper chromatography.	Iron	73-75	ferrochelatase	Rattus norvegicus	16-30
71445-4	1977	The percentage saturation of transferrin was elevated in all relatives with increased iron stores but also in 33% of relatives with normal iron stores.	Iron	86-90	transferrin	Homo sapiens	29-40
71445-4	1977	The percentage saturation of transferrin was elevated in all relatives with increased iron stores but also in 33% of relatives with normal iron stores.	Iron	139-143	transferrin	Homo sapiens	29-40
200254-4	1977	Various conditions increased the caeruloplasmin and some also decreased the iron transferrin level in patients with malignant disease.	Iron	76-80	transferrin	Homo sapiens	81-92
615559-5	1977	These results could be explained either on the basis of functional heterogeneity of transferrin bound iron, or of a new protein.	Iron	102-106	transferrin	Homo sapiens	84-95
198807-5	1977	The shift in the Fe K-edge of cytochrome oxidase upon reduction is small (about 2 e V or 3 times 10(-19 J) and is comparable to that previously observed for the reduction of the heme iron of cytochrome c.	Iron	183-187	cytochrome c, somatic	Homo sapiens	191-203
891100-0	1977	Effects of hexachlorobenzene feeding and iron overload on enzymes of haem biosynthesis and cytochrome P 450 in rat liver.	Iron	41-45	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	91-107
19087-0	1977	Iron exchange between transferrin molecules mediated by phosphate compounds and other cell metabolites.	Iron	0-4	transferrin	Homo sapiens	22-33
19087-1	1977	The ability of a large number of cellular metabolites to release iron from transferrin was investigated by measuring the rate at which they could mediate iron exchange between two types of transferrin.	Iron	65-69	transferrin	Homo sapiens	75-86
19087-1	1977	The ability of a large number of cellular metabolites to release iron from transferrin was investigated by measuring the rate at which they could mediate iron exchange between two types of transferrin.	Iron	65-69	transferrin	Homo sapiens	189-200
19087-1	1977	The ability of a large number of cellular metabolites to release iron from transferrin was investigated by measuring the rate at which they could mediate iron exchange between two types of transferrin.	Iron	154-158	transferrin	Homo sapiens	75-86
19087-4	1977	GTP, 2,3-diphosphoglycerate, ATP, ADP and citrate produced the most rapid exchange of iron between the two types of transferrin, but many other compounds showed some degree of activity.	Iron	86-90	transferrin	Homo sapiens	116-127
19087-8	1977	The rate of iron exchange from the oxalate - iron - transferrin complex was much lower than from bicarbonate - iron - transferrin.	Iron	12-16	transferrin	Homo sapiens	52-63
19087-8	1977	The rate of iron exchange from the oxalate - iron - transferrin complex was much lower than from bicarbonate - iron - transferrin.	Iron	12-16	transferrin	Homo sapiens	118-129
19087-9	1977	It is concluded that several organic phosphates have the capacity of releasing iron from transferrin.	Iron	79-83	transferrin	Homo sapiens	89-100
911316-1	1977	59Fe uptake by rabbit reticulocytes from human transferrin-bound iron was studied by using transferrin solutions (35, 50, 65, 80 and 100% saturated with iron) whose only common characteristic was their content of diferric transferrin.	Iron	65-69	transferrin	Homo sapiens	47-58
889709-0	1977	The role of iron in the regulation of hepatic transferrin synthesis.	Iron	12-16	transferrin	Rattus norvegicus	46-57
889709-1	1977	The role of iron supply in the regulation of hepatic transferrin synthesis by the isolated perfused rat liver was studied using nutritional iron deficiency as the experimental model.	Iron	12-16	transferrin	Rattus norvegicus	53-64
889709-3	1977	Refeeding with iron, sufficient to restore plasma iron and hepatic ferritin iron but before correction of anaemia, promoted a reduction towards normal in the transferrin synthetic rate.	Iron	15-19	transferrin	Rattus norvegicus	158-169
889709-6	1977	The concentration of liver iron stores appears to be a major regulatory factor in the control of hepatic transferrin synthesis.	Iron	27-31	transferrin	Rattus norvegicus	105-116
327698-1	1977	A short historical review of the antimicrobial effects of siderophilin, the iron chelator in human plasma and serum, is followed by a presentation of the rational basis for assigning it a role in the overall defence mechanisms of the host against infectious disease.	Iron	76-80	transferrin	Homo sapiens	58-70
861377-0	1977	Role of transferrin in determining internal iron distribution.	Iron	44-48	transferrin	Rattus norvegicus	8-19
861377-1	1977	The behavior in vivo of transferrin in loading and unloading iron from its two sites was examined in rats.	Iron	61-65	transferrin	Rattus norvegicus	24-35
861377-4	1977	In 15 groups of animals in which 3 different iron salts were employed to load transferrin with iron, the mean isotope ratio in the erythron was 1.03 (+/-0.06 SD) and the mean liver ratio was 0.75 (+/-0.21 SD).	Iron	45-49	transferrin	Rattus norvegicus	78-89
861377-4	1977	In 15 groups of animals in which 3 different iron salts were employed to load transferrin with iron, the mean isotope ratio in the erythron was 1.03 (+/-0.06 SD) and the mean liver ratio was 0.75 (+/-0.21 SD).	Iron	95-99	transferrin	Rattus norvegicus	78-89
861377-7	1977	It is concluded that iron atoms from the two sites of transferrin have similar tissue distributions in vivo in the experimental situations examined.	Iron	21-25	transferrin	Rattus norvegicus	54-65
558796-2	1977	Upon dye-sensitized photooxidation of ovotransferrin and ethoxyformylation of human serum transferrin and ovotransferrin, losses in histidine and iron-binding activity were observed.	Iron	146-150	transferrin	Homo sapiens	41-52
323791-2	1977	In the same time, iron is released from serum transferrin, reduced and determined at 535 mn by incubation in a water bath at 55 degrees for five minutes within a formate buffered system (pH 2,6; i = 0,05) including bathophenanthroline sulfonate.	Iron	18-22	transferrin	Homo sapiens	46-57
870791-4	1977	Both serum iron and transferrin saturation were significantly higher in family members with iron overload than in those who were not affected.	Iron	92-96	transferrin	Homo sapiens	20-31
870791-5	1977	Only transferrin saturation was significantly correlated with the severity of hepatic iron deposition.	Iron	86-90	transferrin	Homo sapiens	5-16
870073-0	1977	Iron removal from transferrin.	Iron	0-4	transferrin	Homo sapiens	18-29
870073-2	1977	We have studied the facilitation of iron transfer from transferrin to desferrioxamine by various anions.	Iron	36-40	transferrin	Homo sapiens	55-66
870073-3	1977	Most of the anions which can substitute for HCO-3 in the ternary complex of transferrin - Fe - HCO3 do not facilitate iron transfer; anions which do facilitate iron transfer do not necessarily form stable ternary complexes.	Iron	160-164	transferrin	Homo sapiens	76-87
870073-5	1977	We suggest that the transfer of iron from transferrin to desferrioxamine involves a substitution step and a subsequent chelation step, and that the efficiency of the overall reaction is a function of both these attributes of the anion.	Iron	32-36	transferrin	Homo sapiens	42-53
194269-0	1977	ESR signal from iron transferrin and caeruloplasmin in the presence of ferrous ions.	Iron	16-20	transferrin	Homo sapiens	21-32
851436-0	1977	Iron transport from Sepharose-bound transferrin.	Iron	0-4	transferrin	Homo sapiens	36-47
64857-6	1977	The other gene, also carried on the sixth chromosome and, in the first family, marked by the HLA A11, B27, CW2 haplotype might result in an increased absorption of dietary iron.	Iron	172-176	melanocortin 2 receptor accessory protein	Homo sapiens	102-105
845685-4	1977	These iron binding substances were identified as ferritin, transferrin and a low molecular weight form by elution characteristics on chromatography and by immunological technique.	Iron	6-10	transferrin	Homo sapiens	59-70
13868-0	1977	Functional equivalence of iron bound to human transferrin at low pH or high pH.	Iron	26-30	transferrin	Homo sapiens	46-57
192508-2	1977	Those patients with clinically active disease show higher caeruloplasmin levels and lower iron transferrin levels than those with inactive disease.	Iron	90-94	transferrin	Homo sapiens	95-106
405954-8	1977	The transferrin titering is useful to appreciate the nutritional status and the iron therapy opportunity, the prognostic and the immunitary possibilities.	Iron	80-84	transferrin	Homo sapiens	4-15
66835-5	1977	The comparison of the total iron-binding capacity with transferrin level determined by radial immunodiffusion may suggest presence of iron-binding proteins other than transferrin.	Iron	134-138	transferrin	Homo sapiens	55-66
139071-5	1977	The pathogenesis of this disorder based on the formation of an autoantibody with specificity for transferrin thus producing a circulating immune complex which bound the majority of serum iron.	Iron	187-191	transferrin	Homo sapiens	97-108
300303-4	1977	Depletion of cells that adhered to plastic or ingested iron powder to give populations containing on average 90% lymphocytes, also reduced the PHA response, but to a lesser extent.	Iron	55-59	lamin B receptor	Homo sapiens	143-146
830225-0	1977	Effect of iron saturation of transferrin on hepatic iron uptake: an in vitro study.	Iron	10-14	transferrin	Rattus norvegicus	29-40
830225-0	1977	Effect of iron saturation of transferrin on hepatic iron uptake: an in vitro study.	Iron	52-56	transferrin	Rattus norvegicus	29-40
830225-1	1977	Studies were performed to delineate the effect of percentage of saturation of transferrin and total iron concentration on the rate of uptake of iron by the perfused rat liver.	Iron	144-148	transferrin	Rattus norvegicus	78-89
830225-4	1977	However, raising the concentration of iron in the perfusate while maintaining a constant saturation of transferrin did increase the uptake of iron by the liver.	Iron	142-146	transferrin	Rattus norvegicus	103-114
830225-5	1977	At similar concentrations of iron and transferrin saturation, iron-deficient livers took up greater amounts of iron than did normal livers.	Iron	62-66	transferrin	Rattus norvegicus	38-49
830225-5	1977	At similar concentrations of iron and transferrin saturation, iron-deficient livers took up greater amounts of iron than did normal livers.	Iron	62-66	transferrin	Rattus norvegicus	38-49
830225-6	1977	In our experiments, the hepatic uptake of transferrin-bound iron is determined by (1) the concentration of iron in perfusate and (2) the status of iron stores in the liver being perfused.	Iron	60-64	transferrin	Rattus norvegicus	42-53
830225-6	1977	In our experiments, the hepatic uptake of transferrin-bound iron is determined by (1) the concentration of iron in perfusate and (2) the status of iron stores in the liver being perfused.	Iron	107-111	transferrin	Rattus norvegicus	42-53
830225-6	1977	In our experiments, the hepatic uptake of transferrin-bound iron is determined by (1) the concentration of iron in perfusate and (2) the status of iron stores in the liver being perfused.	Iron	107-111	transferrin	Rattus norvegicus	42-53
830782-3	1977	In addition to the previously demonstrated selective tissue uptake of iron from the two binding sites of transferrin, the Fletcher-Huehns hypothesis predicts that iron absorbed by the intestine is delivered selectively to the erythroblast-oriented iron-binding site of transferrin in portal plasma.	Iron	163-167	transferrin	Rattus norvegicus	269-280
830782-0	1977	In vivo evidence for the functional heterogeneity of transferrin-bound iron.	Iron	71-75	transferrin	Rattus norvegicus	53-64
830782-8	1977	These results support the concept of selective release of iron to erythroblast-oriented binding sites of portal plasma transferrin by intestinal cells during absorption.	Iron	58-62	transferrin	Rattus norvegicus	119-130
830782-2	1977	Selective uptake by erythroid precursors of radioiron from portal vein plasma transferrin during intestinal iron absorption.	Iron	49-53	transferrin	Rattus norvegicus	78-89
830782-3	1977	In addition to the previously demonstrated selective tissue uptake of iron from the two binding sites of transferrin, the Fletcher-Huehns hypothesis predicts that iron absorbed by the intestine is delivered selectively to the erythroblast-oriented iron-binding site of transferrin in portal plasma.	Iron	70-74	transferrin	Rattus norvegicus	105-116
830782-9	1977	Combined with previously demonstrated selective tissue uptake of iron from transferrin, these experiments offer strong support for the active role of transferrin in the internal iron exchange of the rat.	Iron	65-69	transferrin	Rattus norvegicus	150-161
830782-3	1977	In addition to the previously demonstrated selective tissue uptake of iron from the two binding sites of transferrin, the Fletcher-Huehns hypothesis predicts that iron absorbed by the intestine is delivered selectively to the erythroblast-oriented iron-binding site of transferrin in portal plasma.	Iron	163-167	transferrin	Rattus norvegicus	269-280
830782-9	1977	Combined with previously demonstrated selective tissue uptake of iron from transferrin, these experiments offer strong support for the active role of transferrin in the internal iron exchange of the rat.	Iron	178-182	transferrin	Rattus norvegicus	150-161
318768-0	1977	The iron-binding function of transferrin in iron metabolism.	Iron	4-8	transferrin	Homo sapiens	29-40
202979-3	1977	Imcrease of serum ceruloplasmin as compared to normal was confirmed, with a concomitant decrease of iron-transferrin content.	Iron	100-104	transferrin	Homo sapiens	105-116
272028-4	1977	These findings shed some light on the patterns of serum transferrin bound iron compared with serum Ferastral concentrations which occur with time after intramuscular Ferastral injection.	Iron	74-78	transferrin	Homo sapiens	56-67
272029-4	1977	This binds the iron complex and elutes iron-transferrin which can then be assayed.	Iron	15-19	transferrin	Homo sapiens	44-55
272029-6	1977	Serum unsaturated iron binding capacity may therefore be used to follow the binding of Ferastral iron by transferrin.	Iron	18-22	transferrin	Homo sapiens	105-116
272029-6	1977	Serum unsaturated iron binding capacity may therefore be used to follow the binding of Ferastral iron by transferrin.	Iron	97-101	transferrin	Homo sapiens	105-116
272031-0	1977	Transfer of iron from Ferastral and other organic complexes to transferrin as measured by reticulocyte uptake.	Iron	12-16	transferrin	Homo sapiens	63-74
272031-1	1977	The transfer of iron from the iron carbohydrate complexes, Ferastral, Imferon, and Jectofer, and from ferric chloride has been studied by the effect of such transfer in reducing reticulocyte uptake of 59Fe from labelled transferrin.	Iron	16-20	transferrin	Homo sapiens	220-231
190037-0	1977	In vivo synthesis of iron-free cytochrome c during lead intoxication.	Iron	21-25	cytochrome c, somatic	Homo sapiens	31-43
318768-0	1977	The iron-binding function of transferrin in iron metabolism.	Iron	44-48	transferrin	Homo sapiens	29-40
272031-2	1977	There are plasma factors which augment the transfer of iron from complex to transferrin.	Iron	55-59	transferrin	Homo sapiens	76-87
1052027-0	1976	Transferrin: physiology and function in iron transport.	Iron	40-44	transferrin	Homo sapiens	0-11
272033-2	1977	Transferrin-bound iron reaches a peak value in 4-8 hours and falls towards normal values while circulating iron-complex concentration remains high.	Iron	18-22	transferrin	Homo sapiens	0-11
272033-5	1977	UIBC values fell as transferrin-bound iron increased, but did not reach zero in any subject studied.	Iron	38-42	transferrin	Homo sapiens	20-31
999900-1	1976	In order to determine the conformational relationship of iron binding of human serotransferrin and lactotransferrin, ultraviolet difference spectral studies were performed in the presence of guanidine chloride and perturbants as deuterium oxide, ethylene glycol, glycerol and polyethylene glycol.	Iron	57-61	transferrin	Homo sapiens	79-94
999900-1	1976	In order to determine the conformational relationship of iron binding of human serotransferrin and lactotransferrin, ultraviolet difference spectral studies were performed in the presence of guanidine chloride and perturbants as deuterium oxide, ethylene glycol, glycerol and polyethylene glycol.	Iron	57-61	lactotransferrin	Homo sapiens	99-115
999900-2	1976	In the presence of guanidine chloride solution the molar absorption differences at 292 nm of iron-saturated forms versus iron-free forms of human serotransferrin and lactotransferrin are respectively -16000 +/- 1000 and -14000 +/- 775.	Iron	93-97	transferrin	Homo sapiens	146-161
999900-2	1976	In the presence of guanidine chloride solution the molar absorption differences at 292 nm of iron-saturated forms versus iron-free forms of human serotransferrin and lactotransferrin are respectively -16000 +/- 1000 and -14000 +/- 775.	Iron	93-97	lactotransferrin	Homo sapiens	166-182
999900-2	1976	In the presence of guanidine chloride solution the molar absorption differences at 292 nm of iron-saturated forms versus iron-free forms of human serotransferrin and lactotransferrin are respectively -16000 +/- 1000 and -14000 +/- 775.	Iron	121-125	transferrin	Homo sapiens	146-161
999900-2	1976	In the presence of guanidine chloride solution the molar absorption differences at 292 nm of iron-saturated forms versus iron-free forms of human serotransferrin and lactotransferrin are respectively -16000 +/- 1000 and -14000 +/- 775.	Iron	121-125	lactotransferrin	Homo sapiens	166-182
999900-5	1976	Difference spectral studies in the presence of perturbants show that the apparent exposed tryptophan and tyrosine residues are higher with shorter range perturbants in iron-free forms of both transferrin molecules.	Iron	168-172	transferrin	Homo sapiens	192-203
999900-6	1976	The most important modification of exposed tyrosine residues has been noticed upon removing iron from human lactotransferrin than from serotransferrin.	Iron	92-96	lactotransferrin	Homo sapiens	108-124
999900-6	1976	The most important modification of exposed tyrosine residues has been noticed upon removing iron from human lactotransferrin than from serotransferrin.	Iron	92-96	transferrin	Homo sapiens	135-150
1000084-3	1976	Iron release from the cells depends on transferrin saturation in the medium, but when transferrin is 100% saturated, which normally does not allow iron release, desferrioxamine, 2,3-dihydroxybenzoic acid, rhodotorulic acid, cholythydroxamic acid, and tropolone all promote the mobilization of ferritin iron and its release from cells.	Iron	0-4	transferrin	Homo sapiens	39-50
1000084-5	1976	The incubation of [59Fe]transferrin with tropolone in vitro at a molar ratio of 1:500 results in the transfer of most of the labeled iron to the chelator, reflecting the exceptionally high binding constant of this compound.	Iron	133-137	transferrin	Homo sapiens	24-35
11826-2	1976	A competitive dialysis technique has been used to study the relative affinities of the two iron-binding sites on transferrin molecules and the relative binding strengths of transferrins isolated from plasma of different species.	Iron	91-95	transferrin	Homo sapiens	113-124
11826-11	1976	The average affinity of transferrin for iron depended on species, but the variation was never more than about one order of magnitude.	Iron	40-44	transferrin	Homo sapiens	24-35
11826-17	1976	The relative binding of iron by ovotranferrin and human transferrin was affected little when bicarbonate anion was replaced by oxalate, although the ratio of the two binding constants for ovotranferrin increased.	Iron	24-28	transferrin	Homo sapiens	56-67
1052027-1	1976	Since its identification about 30 years ago transferrin has attracted the interest of many investigators concerned with its structure, metal-binding properties, genetic polymorphism, and especially its role in the transport of iron within the body.	Iron	227-231	transferrin	Homo sapiens	44-55
1052027-2	1976	Transferrin"s two iron-binding sites appear to be structurally identical with equivalent iron binding after addition of iron in vitro.	Iron	18-22	transferrin	Homo sapiens	0-11
1052027-2	1976	Transferrin"s two iron-binding sites appear to be structurally identical with equivalent iron binding after addition of iron in vitro.	Iron	89-93	transferrin	Homo sapiens	0-11
1052027-2	1976	Transferrin"s two iron-binding sites appear to be structurally identical with equivalent iron binding after addition of iron in vitro.	Iron	89-93	transferrin	Homo sapiens	0-11
1052027-3	1976	However, since the experiments of Fletcher and Huehns, the functional homogeneity of transferrin-bound iron has been questioned.	Iron	103-107	transferrin	Homo sapiens	85-96
1052027-4	1976	Understanding of the precise mechanism of iron release from transferrin to receptor sites on reticulocytes and other tissues active in iron exchange is incomplete.	Iron	42-46	transferrin	Homo sapiens	60-71
1052027-4	1976	Understanding of the precise mechanism of iron release from transferrin to receptor sites on reticulocytes and other tissues active in iron exchange is incomplete.	Iron	135-139	transferrin	Homo sapiens	60-71
1052027-8	1976	Until methods are more refined and the transferrin-iron receptor interaction is better understood, the controversy about transferrins"s iron transport function will persist.	Iron	51-55	transferrin	Homo sapiens	39-50
1052029-1	1976	This paper reviews and reports the results of experiments on the mechanism by which iron is delivered from extracellular transferrin to reticulocyte mitochondria in which haem is synthesized.	Iron	84-88	transferrin	Homo sapiens	121-132
1052029-2	1976	It is suggested that transferrin donates the iron directly to mitochondria.	Iron	45-49	transferrin	Homo sapiens	21-32
1052029-3	1976	Transferrin seems to be bound to mitochondria during the process of iron release.	Iron	68-72	transferrin	Homo sapiens	0-11
1052029-4	1976	When the release of iron from transferrin is blocked by haem, the iron-transferrin complex remains bound to mitochondria so that the total amount of transferrin molecules associated with mitochondria increases in haem-treated reticulocytes.	Iron	20-24	transferrin	Homo sapiens	30-41
1052029-4	1976	When the release of iron from transferrin is blocked by haem, the iron-transferrin complex remains bound to mitochondria so that the total amount of transferrin molecules associated with mitochondria increases in haem-treated reticulocytes.	Iron	20-24	transferrin	Homo sapiens	71-82
1052029-4	1976	When the release of iron from transferrin is blocked by haem, the iron-transferrin complex remains bound to mitochondria so that the total amount of transferrin molecules associated with mitochondria increases in haem-treated reticulocytes.	Iron	20-24	transferrin	Homo sapiens	71-82
1052029-6	1976	In haem-deficient reticulocytes, the rate of dissociation of iron from transferrin is accelerated and the uptake of iron by mitochondria is increased.	Iron	61-65	transferrin	Homo sapiens	71-82
1052029-8	1976	Greater amounts of non-haem iron can also be induced in reticulocytes incubated with highly saturated transferrin but, in this case, iron does not seem to be accumulated in mitochondria.	Iron	28-32	transferrin	Homo sapiens	102-113
1052040-1	1976	It seems likely that iron which has crossed the cell membrane and has been released from transferrin enters a labile intermediate pool from which it is available for haem synthesis, for the activation of iron-dependent enzymes, for incorporation into ferritin or for a return to extracellular transferrin.	Iron	21-25	transferrin	Homo sapiens	89-100
1052040-1	1976	It seems likely that iron which has crossed the cell membrane and has been released from transferrin enters a labile intermediate pool from which it is available for haem synthesis, for the activation of iron-dependent enzymes, for incorporation into ferritin or for a return to extracellular transferrin.	Iron	21-25	transferrin	Homo sapiens	293-304
1052040-1	1976	It seems likely that iron which has crossed the cell membrane and has been released from transferrin enters a labile intermediate pool from which it is available for haem synthesis, for the activation of iron-dependent enzymes, for incorporation into ferritin or for a return to extracellular transferrin.	Iron	204-208	transferrin	Homo sapiens	89-100
1052040-3	1976	Iron probably enters the transit pool not only from transferrin but also as a result of endogenous haem breakdown and the mobilization of ferritin iron.	Iron	0-4	transferrin	Homo sapiens	52-63
184092-3	1976	The proximal ligand to the heme iron atom of ferric soybean leghemoglobin is identified as imidazole by comparison of the EPR of leghemoglobin hydroxide, azide, and cyanide with the corresponding derivatives of human hemoglobin.	Iron	32-36	leghemoglobin A	Glycine max	60-73
999884-0	1976	The detection of four molecular forms of human transferrin during the iron binding process.	Iron	70-74	transferrin	Homo sapiens	47-58
1004497-0	1976	Studies on iron uptake and micelle formation in ferritin and apoferritin.	Iron	11-15	ferritin heavy chain	Equus caballus	61-72
1004497-1	1976	Iron uptake and micelle formation in ferritin and apoferritin have been followed both spectrophotometrically and by means of sedimentation velocity experiments.	Iron	0-4	ferritin heavy chain	Equus caballus	50-61
1004497-5	1976	"Native" and "reduced" apoferritin show a similar iron incorporation, but the reconstitution products markedly differ in terms of their iron distribution.	Iron	50-54	ferritin heavy chain	Equus caballus	23-34
989894-0	1976	Iron sufficiency in breast-fed infants and the availability of iron from human milk.	Iron	63-67	Weaning weight-maternal milk	Bos taurus	79-83
989894-4	1976	Studies of iron absorption from breast milk and cow"s milk were performed in ten normal adults.	Iron	11-15	Weaning weight-maternal milk	Bos taurus	39-43
989894-5	1976	The absorption of iron from the human milk was significantly higher.	Iron	18-22	Weaning weight-maternal milk	Bos taurus	38-42
989894-6	1976	These findings suggest that the iron present in human milk is sufficient to meet the iron requirements of the exclusively breast-fed infant until he approximately triples his birthweight.	Iron	32-36	Weaning weight-maternal milk	Bos taurus	54-58
989894-6	1976	These findings suggest that the iron present in human milk is sufficient to meet the iron requirements of the exclusively breast-fed infant until he approximately triples his birthweight.	Iron	85-89	Weaning weight-maternal milk	Bos taurus	54-58
184092-3	1976	The proximal ligand to the heme iron atom of ferric soybean leghemoglobin is identified as imidazole by comparison of the EPR of leghemoglobin hydroxide, azide, and cyanide with the corresponding derivatives of human hemoglobin.	Iron	32-36	leghemoglobin A	Glycine max	129-142
791006-2	1976	It has been postulated that one of the first steps involved in placental iron transfer involves binding of the maternal transferrin-iron complex to the surface of the placenta and the subsequent removal of iron and release of transferrin back into the maternal circulation.	Iron	73-77	transferrin	Homo sapiens	120-131
974035-3	1976	Iron uptake by all cell types is related to transferrin saturation.	Iron	0-4	transferrin	Homo sapiens	44-55
791006-2	1976	It has been postulated that one of the first steps involved in placental iron transfer involves binding of the maternal transferrin-iron complex to the surface of the placenta and the subsequent removal of iron and release of transferrin back into the maternal circulation.	Iron	73-77	transferrin	Homo sapiens	226-237
791006-2	1976	It has been postulated that one of the first steps involved in placental iron transfer involves binding of the maternal transferrin-iron complex to the surface of the placenta and the subsequent removal of iron and release of transferrin back into the maternal circulation.	Iron	132-136	transferrin	Homo sapiens	120-131
791006-2	1976	It has been postulated that one of the first steps involved in placental iron transfer involves binding of the maternal transferrin-iron complex to the surface of the placenta and the subsequent removal of iron and release of transferrin back into the maternal circulation.	Iron	132-136	transferrin	Homo sapiens	226-237
791006-2	1976	It has been postulated that one of the first steps involved in placental iron transfer involves binding of the maternal transferrin-iron complex to the surface of the placenta and the subsequent removal of iron and release of transferrin back into the maternal circulation.	Iron	132-136	transferrin	Homo sapiens	120-131
791006-2	1976	It has been postulated that one of the first steps involved in placental iron transfer involves binding of the maternal transferrin-iron complex to the surface of the placenta and the subsequent removal of iron and release of transferrin back into the maternal circulation.	Iron	132-136	transferrin	Homo sapiens	226-237
973651-2	1976	Using an in vitro heme synthesis method, the patient"s serum produced tenfold inhibition of erythropoietin-stimulated radioactive iron (Fe59) incorporation into heme of normal human marrow at 72 hours, as compared with AB serum.	Iron	130-134	erythropoietin	Homo sapiens	92-106
974036-0	1976	Chelate mediated transfer of iron from transferrin to desferrioxamine.	Iron	29-33	transferrin	Homo sapiens	39-50
976191-13	1976	It is suggested that the increased concentration of renin in the serum of women during the first 19 weeks of pregnancy and in the serum of rats that are rapidly expanding their red cell volume are related to a decrease in iron stores.	Iron	222-226	renin	Homo sapiens	52-57
974036-1	1976	Desferrioxamine, widely used for the treatment of iron overload in Cooley"s anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin.	Iron	91-95	transferrin	Homo sapiens	154-165
974036-1	1976	Desferrioxamine, widely used for the treatment of iron overload in Cooley"s anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin.	Iron	91-95	transferrin	Homo sapiens	154-165
974036-3	1976	However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine.	Iron	113-117	transferrin	Homo sapiens	161-172
974113-1	1976	The iron-saturated and iron-free (apo) forms of bovine transferrin and lactoferrin were digested with trypsin and the digests analysed by column chromatography and electrophoresis.	Iron	4-8	serotransferrin	Bos taurus	55-66
12556-1	1976	Isolated rat liver mitochondria accumulate iron from the suspending medium when [59Fe]transferrin is used as a model compound.	Iron	43-47	transferrin	Rattus norvegicus	86-97
974113-3	1976	Digestion of iron-transferrin yielded two iron-binding fragments with molecular weights of 32 000 and 38 500 whereas apotransferrin yielded only the larger fragment.	Iron	13-17	serotransferrin	Bos taurus	18-29
974113-3	1976	Digestion of iron-transferrin yielded two iron-binding fragments with molecular weights of 32 000 and 38 500 whereas apotransferrin yielded only the larger fragment.	Iron	42-46	serotransferrin	Bos taurus	18-29
12556-8	1976	The results indicate that the energy-dependent accumulation of [59Fe]transferrin represents a process by which mitochondria accumulate iron from transferrin.	Iron	135-139	transferrin	Rattus norvegicus	69-80
12556-8	1976	The results indicate that the energy-dependent accumulation of [59Fe]transferrin represents a process by which mitochondria accumulate iron from transferrin.	Iron	135-139	transferrin	Rattus norvegicus	145-156
953365-1	1976	The iron status of a population of 1564 subjects living in the northwestern United States was evaluated by measurements of transferrin saturation, red cell protoporphyrin, and serum ferritin.	Iron	4-8	transferrin	Homo sapiens	123-134
982076-11	1976	In the case of radiogallium and radioindium, the binding macromolecule is transferrin, and it is known that some cells have specific receptor sites for transferrin-bound iron on the cell membrane.	Iron	170-174	transferrin	Homo sapiens	74-85
982076-11	1976	In the case of radiogallium and radioindium, the binding macromolecule is transferrin, and it is known that some cells have specific receptor sites for transferrin-bound iron on the cell membrane.	Iron	170-174	transferrin	Homo sapiens	152-163
976260-1	1976	Analysis of human serum transferrin on gel isoelectric focusing resolved this iron-transport protein into two iron-containing components which were identified by the use of radioactively labelled iron and iron-specific stain.	Iron	78-82	transferrin	Homo sapiens	24-35
976260-1	1976	Analysis of human serum transferrin on gel isoelectric focusing resolved this iron-transport protein into two iron-containing components which were identified by the use of radioactively labelled iron and iron-specific stain.	Iron	110-114	transferrin	Homo sapiens	24-35
976260-1	1976	Analysis of human serum transferrin on gel isoelectric focusing resolved this iron-transport protein into two iron-containing components which were identified by the use of radioactively labelled iron and iron-specific stain.	Iron	110-114	transferrin	Homo sapiens	24-35
968452-6	1976	The iron saturation of serum transferrin was unchanged.	Iron	4-8	transferrin	Homo sapiens	29-40
782924-3	1976	In the very rare human autosomal recessive trait, atransferrinemia, there is an almost total lack of transferrin and gross maldistribution of iron through the body.	Iron	142-146	transferrin	Homo sapiens	51-62
1009023-1	1976	Iron exchange in the pregnant rat was quantitated by repeated determinations of plasma iron turnover (PIT), transferrin iron distribution and measurements of storage iron and food iron utilization employing selective radio-iron probes.	Iron	0-4	transferrin	Rattus norvegicus	108-119
954750-2	1976	From determination of their molecular weights, their electrophoretic and iron-binding properties it was established that one was a mucosal ferritin and the other a mucosal transferrin.	Iron	73-77	transferrin	Rattus norvegicus	172-183
948027-8	1976	In addition, ascorbic acid protects cytochrome P-450 and aniline hydroxy lase activity from inhibition by ferrous iron chelators such as alpha, alpha"-dipyridyl.	Iron	114-118	cytochrome P450 3A14	Cavia porcellus	36-52
948027-10	1976	These studies suggest that there is an interaction between ascorbic acid and cytochrome P-450 involving the reduced form of the heme iron.	Iron	133-137	cytochrome P450 3A14	Cavia porcellus	77-93
823289-2	1976	We studied the relation between transferrin concentration and total iron binding capacity for human normal and variant transferrins.	Iron	68-72	transferrin	Homo sapiens	32-43
954750-8	1976	Differences were also found in vitro in the iron-binding of mucosal transferrin as compared with plasma transferrin.	Iron	44-48	transferrin	Rattus norvegicus	68-79
955086-0	1976	Comparative circular dichroism studies of iron-free and iron-saturated forms of human serotransferrin and lactortransferrin.	Iron	42-46	transferrin	Homo sapiens	86-101
9066-0	1976	Iron-dependent binding of 8-anilinonaphthalene-1-sulphonate by both lactoferrin and transferrin.	Iron	0-4	transferrin	Homo sapiens	84-95
955086-0	1976	Comparative circular dichroism studies of iron-free and iron-saturated forms of human serotransferrin and lactortransferrin.	Iron	56-60	transferrin	Homo sapiens	86-101
947406-2	1976	Iron uptake from transferrin by copper-deficient reticulocytes was 52% of normal, and the rate of heme synthesis was 33% of normal.	Iron	0-4	transferrin	Homo sapiens	17-28
962925-0	1976	Effect of hemin and isonicotinic acid hydrazide on the uptake of iron from transferrin by isolated rat liver mitochondria.	Iron	65-69	transferrin	Rattus norvegicus	75-86
945745-1	1976	The effect of high-spin heme iron in beef liver catalase on the longitudinal and transverse proton relaxation rates of the solvent has been used to probe the environment of the paramagnetic center.	Iron	29-33	catalase	Homo sapiens	48-56
949508-1	1976	We have compared the plasma clearance rate of radioactive iron in cows both as ferric chloride and as iron specifically bound to transferrin.	Iron	58-62	serotransferrin	Bos taurus	129-140
949508-1	1976	We have compared the plasma clearance rate of radioactive iron in cows both as ferric chloride and as iron specifically bound to transferrin.	Iron	102-106	serotransferrin	Bos taurus	129-140
182488-8	1976	This supports the model that one of the pyridine nitrogens of metyrapone is coordinated to the iron of cytochrome P-450.	Iron	95-99	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-119
817959-5	1976	On restriction of dietary iron intake, cytochrome P-450 and oxidative enzyme activity fell sharply, but were completely restored in 24 hr by oral iron supplementation, whereas parenteral iron administration was ineffective.	Iron	26-30	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	39-55
819118-4	1976	The results suggest that iron, which is a component of hog gastric mucin, is a factor involved in the establishment of meningococcal infection in mice.	Iron	25-29	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	59-72
194788-3	1976	DTPP produced a moderate stimulation of the iron-containing enzymes (catalase, peroxidase, cytochroxidase) which led to an increased oxygen consumption.	Iron	44-48	catalase	Rattus norvegicus	69-77
817959-5	1976	On restriction of dietary iron intake, cytochrome P-450 and oxidative enzyme activity fell sharply, but were completely restored in 24 hr by oral iron supplementation, whereas parenteral iron administration was ineffective.	Iron	146-150	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	39-55
817959-5	1976	On restriction of dietary iron intake, cytochrome P-450 and oxidative enzyme activity fell sharply, but were completely restored in 24 hr by oral iron supplementation, whereas parenteral iron administration was ineffective.	Iron	146-150	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	39-55
817959-6	1976	These findings suggest that intestinal drug metabolism is localized primarily in the upper villous cells of the proximal intestinal mucosa, that cytochrome P-450 is synthesized in maturing epithelial cells as they migrate from the crypts to the tip of the mucosal villi, and that this process is dependent critically upon absorption of iron from the intestinal lumen.	Iron	336-340	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	145-161
817667-5	1976	In the less polluted and less iron-rich (1.2 muM) seawater sample, biodegradation of SL crude oil was considerably slower (21% in 3 days) and the addition of chelated iron had a stimulating effect.	Iron	167-171	latexin	Homo sapiens	45-48
1275959-3	1976	In all of them, the following laboratory counts were done: hemoglobin, hematocrit, leukocyte; also, measurement of protein electrophoresis, of serum iron and of total fixation capacity of iron (transferrin).	Iron	188-192	transferrin	Homo sapiens	194-205
1275959-6	1976	In spite of decreased levels of hemoglobin and iron, it was shown that transferrin did not rise, but otherwise, dropped in these patients; therefore, the capacity to convey and fix iron is decreased.	Iron	181-185	transferrin	Homo sapiens	71-82
6057-3	1976	The pH-dependent iron dissociation studies of biologically labeled transferrin solutions indicated that Fe3+, bound at the site from which the metal was initially utilized by the cells, dissociated between pH 5.8 and 7.4.	Iron	17-21	transferrin	Homo sapiens	67-78
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	51-55	transferrin	Homo sapiens	39-50
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	51-55	transferrin	Homo sapiens	222-233
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	39-50
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	222-233
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	39-50
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	222-233
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	39-50
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	222-233
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	39-50
6057-5	1976	These findings suggest that each human transferrin iron-binding site has different acid-base iron-binding properties which could be related to the observed heterogenic rabbit reticulocyte iron-donating properties of human transferrin and identifies that the near neutral iron-binding site initially surrenders its iron to these cells.	Iron	93-97	transferrin	Homo sapiens	222-233
8889-2	1976	At the low pH, the iron exists in the HPp in the high-spin species.	Iron	19-23	familial progressive hyperpigmentation 1	Homo sapiens	38-41
817667-5	1976	In the less polluted and less iron-rich (1.2 muM) seawater sample, biodegradation of SL crude oil was considerably slower (21% in 3 days) and the addition of chelated iron had a stimulating effect.	Iron	30-34	latexin	Homo sapiens	45-48
1253527-11	1976	Non-ferritin iron in the Chang cell cytosol was dialysable, available for binding to transferrin and formed chelates which appeared, on gel chromatography, to be of low molecular weight.	Iron	13-17	transferrin	Homo sapiens	85-96
1253437-4	1976	This difference is attributed to circulating iron being present both as iron dextran as as transferrin-bound iron.	Iron	45-49	transferrin	Homo sapiens	91-102
3195-0	1976	The effect of pH upon human transferrin: selective labelling of the two iron-binding sites.	Iron	72-76	transferrin	Homo sapiens	28-39
3195-1	1976	The influence of pH changes upon the iron-binding properties of transferrin was investigated in the absence of chelating agents.	Iron	37-41	transferrin	Homo sapiens	64-75
3195-3	1976	At pH values below 6.7, diferric transferrin readily loses iron.	Iron	59-63	transferrin	Homo sapiens	33-44
770424-5	1976	Under optimal iron concentrations, however, strain SS1 caused precipitation of iron (adsorbed to cellular material) in broth cultures, which was 10 to 100 times that mediated by some "non-iron" microorganisms.	Iron	14-18	major histocompatibility complex, class II, DR beta 1	Homo sapiens	51-54
770424-5	1976	Under optimal iron concentrations, however, strain SS1 caused precipitation of iron (adsorbed to cellular material) in broth cultures, which was 10 to 100 times that mediated by some "non-iron" microorganisms.	Iron	79-83	major histocompatibility complex, class II, DR beta 1	Homo sapiens	51-54
770424-5	1976	Under optimal iron concentrations, however, strain SS1 caused precipitation of iron (adsorbed to cellular material) in broth cultures, which was 10 to 100 times that mediated by some "non-iron" microorganisms.	Iron	79-83	major histocompatibility complex, class II, DR beta 1	Homo sapiens	51-54
770424-7	1976	One hundred micrograms of Mn(II) per ml and possibly 10 mug of either Co(II) or  Ni(II) per ml could inhibit iron uptake in the deposition system.	Iron	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
1253527-14	1976	Loss of non-ferritin iron from the cells occurred only when the transferrin in the medium was unsaturated.	Iron	21-25	transferrin	Homo sapiens	64-75
1016270-2	1976	Low serum iron level with a transferrin saturation below 16% is a crucial aetiologic factor of anaemia in haemodialysed patients.	Iron	10-14	transferrin	Homo sapiens	28-39
12844-0	1976	The binding and release of iron by transferrin.	Iron	27-31	transferrin	Homo sapiens	35-46
3172-0	1975	Iron oxidation and transferrin formation by phosvitin.	Iron	0-4	Casein kinase II subunit beta	Gallus gallus	44-53
172141-6	1975	Transferrin readily takes over iron from its ATP or pyrophosphate complex.	Iron	31-35	transferrin	Homo sapiens	0-11
1244908-4	1976	Time course and temperature dependence studies suggest the endocytosis of transferrin may be an important mechanism in delivery of iron to the developing red cell.	Iron	131-135	transferrin	Rattus norvegicus	74-85
3172-1	1975	The catalytic activity of phosvitin in Fe(II) oxidation and the addition of iron to transferrin were studied under various conditions.	Iron	76-80	Casein kinase II subunit beta	Gallus gallus	26-35
1255-3	1975	Upon the addition of iron, malonaldehyde production in the cells started immediately but ceased within 30-60 min, and the response was dose-related with iron concentrations ranging from 19 to 187 muM.	Iron	21-25	latexin	Homo sapiens	196-199
1236505-0	1975	Uptake of transferrin-bound iron by rat cells in tissue culture.	Iron	28-32	transferrin	Rattus norvegicus	10-21
1209217-4	1975	Furthermore, the ability develops to take up tightly bound iron from transferrin, to synthesize large amounts of hemin and to express the few structural genes for hemoglobin polypeptides preferentially.	Iron	59-63	transferrin	Homo sapiens	69-80
1265-1	1975	Absorption and emission spectra and binding characteristics of iron-free cytochrome c.	Iron	63-67	cytochrome c, somatic	Homo sapiens	73-85
1265-2	1975	A cytochrome c derivative from which iron is removed has been prepared and characterized.	Iron	37-41	cytochrome c, somatic	Homo sapiens	2-14
1238108-2	1975	Circular dichroism spectra in the far-ultraviolet show that the leghemoglobins all have a high alpha-helix content (soybean leghemoglobin a, 55%) regardless of the nature of bound ligands and oxidation or spin state of the heme iron.	Iron	228-232	leghemoglobin A	Glycine max	64-77
1255-3	1975	Upon the addition of iron, malonaldehyde production in the cells started immediately but ceased within 30-60 min, and the response was dose-related with iron concentrations ranging from 19 to 187 muM.	Iron	153-157	latexin	Homo sapiens	196-199
1255-12	1975	It is concluded that iron enters the cell, then is probably reduced inside the cell by NADPH via the NADPH-cytochrome P-450 reductase, and in the reduced state initiates lipid peroxidation.	Iron	21-25	cytochrome p450 oxidoreductase	Homo sapiens	101-133
1242550-0	1975	Ferrous and hemoglobin-59Fe absorption from supplemented cow milk in infants with normal and depleted iron stores.	Iron	102-106	Weaning weight-maternal milk	Bos taurus	61-65
1242550-1	1975	Small amounts of milk do inhibit ferrous iron absorption from a 5 mg 59Fe2+ dose in 1- to 18-month-old infants.	Iron	41-45	Weaning weight-maternal milk	Bos taurus	17-21
1242550-6	1975	The low iron content of milk (50 mug Fe/100 ml) and its poor bioavailability (approximately5% in infants with normal iron stores) would require a dialy consumption of 32 1 of unfortified milk to cover infants daily iron requirement of 0.8 mg/day.	Iron	8-12	Weaning weight-maternal milk	Bos taurus	24-28
1237801-0	1975	Functional equivalence of the two iron-binding sites of human transferrin.	Iron	34-38	transferrin	Homo sapiens	62-73
1242550-6	1975	The low iron content of milk (50 mug Fe/100 ml) and its poor bioavailability (approximately5% in infants with normal iron stores) would require a dialy consumption of 32 1 of unfortified milk to cover infants daily iron requirement of 0.8 mg/day.	Iron	37-39	Weaning weight-maternal milk	Bos taurus	24-28
1242550-7	1975	The supplementation of 2--3 milk meals per day with 5 mg hemoglobin iron each meets the whole iron requirements of infants with depleted and normal iron stores respectively and can be used for iron prophylaxis in infancy during the first and second year.	Iron	68-72	Weaning weight-maternal milk	Bos taurus	28-32
1242550-7	1975	The supplementation of 2--3 milk meals per day with 5 mg hemoglobin iron each meets the whole iron requirements of infants with depleted and normal iron stores respectively and can be used for iron prophylaxis in infancy during the first and second year.	Iron	94-98	Weaning weight-maternal milk	Bos taurus	28-32
1242550-7	1975	The supplementation of 2--3 milk meals per day with 5 mg hemoglobin iron each meets the whole iron requirements of infants with depleted and normal iron stores respectively and can be used for iron prophylaxis in infancy during the first and second year.	Iron	94-98	Weaning weight-maternal milk	Bos taurus	28-32
1242550-7	1975	The supplementation of 2--3 milk meals per day with 5 mg hemoglobin iron each meets the whole iron requirements of infants with depleted and normal iron stores respectively and can be used for iron prophylaxis in infancy during the first and second year.	Iron	94-98	Weaning weight-maternal milk	Bos taurus	28-32
171296-0	1975	Letter: Iron to sulfur bonding in cytochrome C studied by x-ray photoelectron spectroscopy.	Iron	8-12	cytochrome c, somatic	Homo sapiens	34-46
1182201-3	1975	Same carbohydrate composition was detected in the apoferritin from iron rich ferritins.	Iron	67-71	ferritin heavy chain	Equus caballus	50-61
173410-1	1975	The ESR spectra of animal tissues have been recorded at 13-43 degrees K. The reduction of the ESR signal intensities of the Fe-S proteins have been found in starving mice which is due to the substrate diminishing in these animal tissues.	Iron	124-128	esterase 5 regulator	Mus musculus	4-7
173410-1	1975	The ESR spectra of animal tissues have been recorded at 13-43 degrees K. The reduction of the ESR signal intensities of the Fe-S proteins have been found in starving mice which is due to the substrate diminishing in these animal tissues.	Iron	124-128	esterase 5 regulator	Mus musculus	94-97
1104000-4	1975	Thus, by tight binding transferrin withholds the iron from invading microorganisms required for their optimal growth.	Iron	49-53	transferrin	Homo sapiens	23-34
241383-2	1975	Iron-saturated transferrin does not bind the vanadyl ion.	Iron	0-4	transferrin	Homo sapiens	15-26
241383-6	1975	Results with mixed Fe(III)-VO(IV) transferrin complexes suggest that iron shows a slight tendency to bind at the B site over the A site pH 7.5 and 9.0.	Iron	69-73	transferrin	Homo sapiens	34-45
1176811-0	1975	In vivo evidence for the functional heterogeneity of transferrin-bound iron.	Iron	71-75	transferrin	Rattus norvegicus	53-64
2584-3	1975	(1) For ferrous alkylated cytochrome c, a Raman line sensitive to the replacement of an axial ligand of the heme iron uas found around 1540 cm=1.	Iron	113-117	cytochrome c, somatic	Homo sapiens	26-38
1236569-4	1975	The low transferrin levels, particularly in preterm babies, may caution the use of iron especially by the parenteral route in the neonatal period, but we are wary of abandoning on this evidence alone the well tried clinical custom of giving oral iron to preterm babies who are not breast fed.	Iron	83-87	transferrin	Homo sapiens	8-19
1176811-4	1975	A sample of iron-poor plasma transferrin brought to 90 per cent iron saturation by the addition of 59Fe-nitrilotriacetate was mixed with a similarly labeled plasma sample of 55Fe-transferrin at 10 per cent iron saturation.	Iron	64-68	transferrin	Rattus norvegicus	29-40
1176811-4	1975	A sample of iron-poor plasma transferrin brought to 90 per cent iron saturation by the addition of 59Fe-nitrilotriacetate was mixed with a similarly labeled plasma sample of 55Fe-transferrin at 10 per cent iron saturation.	Iron	64-68	transferrin	Rattus norvegicus	29-40
1176811-8	1975	These studies add further support for the Fletcher-Huehns hypothesis of the functional heterogeneity of the transferrin iron pool in the rat.	Iron	120-124	transferrin	Rattus norvegicus	108-119
1176811-2	1975	Studies of transferrin at high and low iron saturation.	Iron	39-43	transferrin	Rattus norvegicus	11-22
1176811-3	1975	The functional heterogeneity of the transferrin iron pool of rats was studied by means of selective radioiron labeling of transferrin at high and low iron saturations.	Iron	48-52	transferrin	Rattus norvegicus	36-47
1176811-3	1975	The functional heterogeneity of the transferrin iron pool of rats was studied by means of selective radioiron labeling of transferrin at high and low iron saturations.	Iron	105-109	transferrin	Rattus norvegicus	122-133
1176811-4	1975	A sample of iron-poor plasma transferrin brought to 90 per cent iron saturation by the addition of 59Fe-nitrilotriacetate was mixed with a similarly labeled plasma sample of 55Fe-transferrin at 10 per cent iron saturation.	Iron	12-16	transferrin	Rattus norvegicus	29-40
1158867-8	1975	In 15 min of irradiation, apo-hemopexin loses 50% of its ability to form a low spin hemichrome complex with deuteroheme while only 10% of the ligand coordination to heme iron of the deuteroheme-hemopexin is lost.	Iron	170-174	hemopexin	Oryctolagus cuniculus	30-39
170959-4	1975	MNMT-cytochrome c was found to be, structurally and conformationally, a single isomer, reducible with ascorbate, with a small, but definite affinity for both oxidation with molecular oxygen and binding of CO. Conformationally, in both valence states of the metal atom, it represents a molecular form with native-like conformation with small but definite perturbations in the immediate vicinity of the heme group, reflected by the destabilization of the Met-80-S-Fe linkage.	Iron	462-464	cytochrome c, somatic	Homo sapiens	5-17
1147997-0	1975	Cytochrome P-450 and drug metabolism in intestinal villous and crypt cells of rats: effect of dietary iron.	Iron	102-106	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
1041406-5	1975	It is concluded that, during egg laying and after oestrogen treatment, plasma iron bound to transferrin is taken up by the liver, incorporated into phosvitin and is then secreted into the plasma leading to elevation of the plasma iron concentration and transfer of iron to the ova.	Iron	78-82	Casein kinase II subunit beta	Gallus gallus	148-157
1137910-4	1975	We found a conversion factor for expressing the maximum amount of iron bound by 1 mg of transferrin.	Iron	66-70	transferrin	Homo sapiens	88-99
1137910-9	1975	Measurement of transferrin concentration can be used to distinguish iron deficiency anemia from anemia resulting from chronic disorders, but offers no advantages over existing methods for estimating total iron-binding capacity.	Iron	68-72	transferrin	Homo sapiens	15-26
1125327-5	1975	A proportion of the 59-Fe incorporated into the stroma and low molecular weight iron fractions during a 1 h incubation with 59-Fe-labelled transferrin was mobilised into ferritin and haemoglobin during a subsequent 4-h "cold-chase".	Iron	80-84	transferrin	Rattus norvegicus	139-150
236520-0	1975	Difference between the two iron-binding sites of transferrin.	Iron	27-31	transferrin	Homo sapiens	49-60
1130307-0	1975	Effect of milk and casein on the absorption of supplemental iron in the mouse and chick.	Iron	60-64	Weaning weight-maternal milk	Bos taurus	10-14
1130307-1	1975	Milk is an attractive vehicle for introducing iron supplements into iron-deficient infants and children.	Iron	46-50	Weaning weight-maternal milk	Bos taurus	0-4
1130307-1	1975	Milk is an attractive vehicle for introducing iron supplements into iron-deficient infants and children.	Iron	68-72	Weaning weight-maternal milk	Bos taurus	0-4
1130307-3	1975	Evidence is presented to clarify the role of the calcium-casein micelles of cow"s milk in binding iron donated by the ferric-nitrilotriacetate (NTA) complex.	Iron	98-102	Weaning weight-maternal milk	Bos taurus	82-86
1130307-7	1975	For the chick, in fact, milk significantly enhanced the absorption of iron from the ferric-NTA chelate.	Iron	70-74	Weaning weight-maternal milk	Bos taurus	24-28
1123558-0	1975	In vivo evidence for the functional heterogeneity of transferrin-bound iron.	Iron	71-75	transferrin	Rattus norvegicus	53-64
1123558-3	1975	Functional heterogeneity of iron atoms bound to transferrin as postulated by Fletcher and Huehns was demonstrated by in vivo studies in rats.	Iron	28-32	transferrin	Rattus norvegicus	48-59
1123558-4	1975	Serum transferrin was selectively double-labeled by adding 59Fe to 90 per cent saturation of iron binding capacity, incubation with rat reticulocytes to reduce the saturation to 50 per cent or less, and then adding back 55Fe.	Iron	93-97	transferrin	Rattus norvegicus	6-17
1123558-8	1975	These studies confirm the hypothesis of Fletcher and Huehns that the iron atoms of transferrin are functionally different and support the concept that transferrin plays a selective role in the distribution of iron to tissues in the rat.	Iron	69-73	transferrin	Rattus norvegicus	83-94
1123558-8	1975	These studies confirm the hypothesis of Fletcher and Huehns that the iron atoms of transferrin are functionally different and support the concept that transferrin plays a selective role in the distribution of iron to tissues in the rat.	Iron	209-213	transferrin	Rattus norvegicus	151-162
1123559-0	1975	In vivo evidence for the functional heterogeneity of transferrin-bound iron.	Iron	71-75	transferrin	Rattus norvegicus	53-64
1123559-3	1975	Iron atoms from the two iron-binding sites of transferrin in the maternal plasma were selectively transferred to fetal tissues across the placenta of the pregnant rat.	Iron	0-4	transferrin	Rattus norvegicus	46-57
1123559-3	1975	Iron atoms from the two iron-binding sites of transferrin in the maternal plasma were selectively transferred to fetal tissues across the placenta of the pregnant rat.	Iron	24-28	transferrin	Rattus norvegicus	46-57
1123559-9	1975	These studies confirm the concept of functional heterogeneity of iron atoms bound to transferrin and indicate that the placenta of rats between the eleventh and twentieth day of pregnancy selectively removes erythroblast-oriented iron from transferrin and diverts it to fetal tissues.	Iron	230-234	transferrin	Rattus norvegicus	240-251
1125261-1	1975	Radioactive iodine-labeled iron-saturated human transferrin was shown to enter the cytosol of rabbit reticulocytes but not erythrocytes, and to be combined therein with a small "carrier" material not identical to the membrane transferrin receptor.	Iron	27-31	transferrin	Homo sapiens	48-59
1103213-9	1975	Those receiving iron showed a rise in haemoglobin, the best results being in the groups receiving 120 and 240 mg of iron together with vitamin B12 and folate.	Iron	16-20	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	143-146
1125261-1	1975	Radioactive iodine-labeled iron-saturated human transferrin was shown to enter the cytosol of rabbit reticulocytes but not erythrocytes, and to be combined therein with a small "carrier" material not identical to the membrane transferrin receptor.	Iron	27-31	transferrin	Homo sapiens	226-237
1120101-0	1975	Iron-donating properties of transferrin.	Iron	0-4	transferrin	Homo sapiens	28-39
1118202-0	1975	[Determination of serum transferrin level and the degree of iron saturation of transferrin helathy children].	Iron	60-64	transferrin	Homo sapiens	79-90
1127111-0	1975	The measurement of iron-binding capacity in serum and purified transferrin with the aid of chemical affinity chromatography.	Iron	19-23	transferrin	Homo sapiens	63-74
1127111-1	1975	In a mew method for the estimation of transferrin by iron-binding capacity iron is added as the tartrate in NaCl with about 10 mM bicarbonate.	Iron	53-57	transferrin	Homo sapiens	38-49
1127111-1	1975	In a mew method for the estimation of transferrin by iron-binding capacity iron is added as the tartrate in NaCl with about 10 mM bicarbonate.	Iron	75-79	transferrin	Homo sapiens	38-49
1127111-3	1975	The iron remaining bound to transferrin is measured without protein precipitation by the use of ferrozine.	Iron	4-8	transferrin	Homo sapiens	28-39
1127111-5	1975	Validation experiments confirm that transferrin in serum and in pure solution is saturated with iron and give some evidence of specificity.	Iron	96-100	transferrin	Homo sapiens	36-47
1191562-3	1975	If so, this could be entirely in accord with current views that the two binding sites of transferrin do not share equal properties of iron exchange with cells.	Iron	134-138	transferrin	Homo sapiens	89-100
1191562-4	1975	At physiological levels of transferrin iron-saturation, it is likely that two populations of Fe1-transferrin molecules form the bulk of the iron-transferrin complex.	Iron	39-43	transferrin	Homo sapiens	27-38
1191562-4	1975	At physiological levels of transferrin iron-saturation, it is likely that two populations of Fe1-transferrin molecules form the bulk of the iron-transferrin complex.	Iron	39-43	transferrin	Homo sapiens	97-108
1191562-4	1975	At physiological levels of transferrin iron-saturation, it is likely that two populations of Fe1-transferrin molecules form the bulk of the iron-transferrin complex.	Iron	39-43	transferrin	Homo sapiens	97-108
1191562-4	1975	At physiological levels of transferrin iron-saturation, it is likely that two populations of Fe1-transferrin molecules form the bulk of the iron-transferrin complex.	Iron	140-144	transferrin	Homo sapiens	27-38
1191562-4	1975	At physiological levels of transferrin iron-saturation, it is likely that two populations of Fe1-transferrin molecules form the bulk of the iron-transferrin complex.	Iron	140-144	transferrin	Homo sapiens	97-108
1191562-4	1975	At physiological levels of transferrin iron-saturation, it is likely that two populations of Fe1-transferrin molecules form the bulk of the iron-transferrin complex.	Iron	140-144	transferrin	Homo sapiens	97-108
234749-11	1975	The results are interpreted in a scheme in which first a transient complex between cytochrome c and the hydrated electron is formed, after which the heme iron is reduced and followed by relaxation of the protein from its oxidized to its reduced conformation.	Iron	154-158	cytochrome c, somatic	Homo sapiens	83-95
234749-16	1975	A reduction mechanism for cytochrome c is favored in which the reduction equivalent from the hydrated electron is transmitted through a specific pathway from the surface of the molecule to the heme iron.	Iron	198-202	cytochrome c, somatic	Homo sapiens	26-38
164225-0	1975	Demonstration by EPR spectroscopy of the functional role of iron in soybean lipoxygenase-1.	Iron	60-64	seed linoleate 13S-lipoxygenase-1	Glycine max	76-90
1120101-2	1975	Diferric human transferrin was shown to be a better iron donor, per iron atom, for rabbit reticulocytes, than was monoferric transferrin obtained by isoelectric focusing.	Iron	52-56	transferrin	Homo sapiens	15-26
1120101-2	1975	Diferric human transferrin was shown to be a better iron donor, per iron atom, for rabbit reticulocytes, than was monoferric transferrin obtained by isoelectric focusing.	Iron	68-72	transferrin	Homo sapiens	15-26
1120101-3	1975	The difference in binding of 125I-labeled monoferric and differic transferrin to reticulocytes may be sufficient to account for the difference in iron uptake.	Iron	146-150	transferrin	Homo sapiens	66-77
1120101-5	1975	In an experiment using 55Fe/59Fe doubly labeled transferrin, one iron binding site of human transferrin was a better iron donor than the other.	Iron	65-69	transferrin	Homo sapiens	48-59
1120101-5	1975	In an experiment using 55Fe/59Fe doubly labeled transferrin, one iron binding site of human transferrin was a better iron donor than the other.	Iron	65-69	transferrin	Homo sapiens	92-103
1120101-1	1975	The transferrin molecule has two specific metal-binding sites, each of which may provide iron for the biosynthesis of hemoglobin by reticulocytes.	Iron	89-93	transferrin	Homo sapiens	4-15
1120101-5	1975	In an experiment using 55Fe/59Fe doubly labeled transferrin, one iron binding site of human transferrin was a better iron donor than the other.	Iron	117-121	transferrin	Homo sapiens	48-59
1120101-5	1975	In an experiment using 55Fe/59Fe doubly labeled transferrin, one iron binding site of human transferrin was a better iron donor than the other.	Iron	117-121	transferrin	Homo sapiens	92-103
1241443-1	1975	All the methods of quantitative estimation of transferrin concentration applied until recently have consisted in calculating the amount of this protein through the amount of iron bound in the blood serum.	Iron	174-178	transferrin	Homo sapiens	46-57
1120101-7	1975	Care was taken in these experiments to demonstrate that labeled iron added to dilute solutions of transferrin was indeed specifically bound to the protein.	Iron	64-68	transferrin	Homo sapiens	98-109
1155252-3	1975	Unlike other transition metals, copper stimulated ferrochelatase activity and there was an interaction between Cu-+-+ and Fe-+-+ in the system such that the Km of Fe-+-+ was dependent on the concentration of copper.	Iron	163-169	ferrochelatase	Rattus norvegicus	50-64
1180419-11	1975	Our method can also be used for determining the transferrin iron binding capacity.	Iron	60-64	transferrin	Homo sapiens	48-59
808936-2	1975	First, an 80% 59Fe-saturated transferrin solution was exposed to reticulocytes to reduce its iron content.	Iron	93-97	transferrin	Rattus norvegicus	29-40
1241443-3	1975	The calculation is based on the fact found by Ehrenberg and Laurell (1955) that two atoms of trivalent iron are selectively bound with one molecule of transferrin.	Iron	103-107	transferrin	Homo sapiens	151-162
4376951-1	1974	Comparison of pig heart aconitase (Kennedy et al., 1972) with yeast (Candida lipolytica) aconitase (Suzuki et al., 1973) reveals similarities in molecular weight and iron content but not in sulphide content.	Iron	166-170	aconitase 2	Sus scrofa	18-33
1121896-2	1975	The iron bound to transferrin is freed with a detergent, reduced to Fe++ with sodium dithionite, and determined with bathophenanthroline disulphonate.	Iron	4-8	transferrin	Homo sapiens	18-29
1121896-2	1975	The iron bound to transferrin is freed with a detergent, reduced to Fe++ with sodium dithionite, and determined with bathophenanthroline disulphonate.	Iron	68-72	transferrin	Homo sapiens	18-29
1136592-0	1975	[Dynamics of ceruloplasmin content and saturation with iron of blood serum transferrin in patients with contagious forms of syphilis in the process of treatment].	Iron	55-59	transferrin	Homo sapiens	75-86
4214890-6	1974	(b) Lactoferrin is Able to Remove the Iron from Transferrin.	Iron	38-42	transferrin	Homo sapiens	48-59
4154211-0	1974	A complex formation of the adrenal iron-sulfur protein (adrenodoxin) with cytochrome c and the decomposition of the iron-sulfur center.	Iron	35-39	cytochrome c, somatic	Homo sapiens	74-86
4471358-0	1974	Interaction of transferrin with iron-binding sites on rat intestinal epithelial cell plasma membranes.	Iron	32-36	transferrin	Rattus norvegicus	15-26
4214890-7	1974	Significant exchange of iron from transferrin to lactoferrin was observed in vitro only at a pH below 7.0 or in the presence of a high concentration of citrate.	Iron	24-28	transferrin	Homo sapiens	34-45
4417862-0	1974	Comparison of the metabolism of iron-labeled transferrin (Fe-TF) and indium-labeled transferrin (In-TF) by the erythropoietic marrow.	Iron	32-36	transferrin	Homo sapiens	45-56
4462622-0	1974	Iron transport intermediates in human reticulocytes and the membrane binding site of iron-transferrin.	Iron	0-4	transferrin	Homo sapiens	90-101
4462622-0	1974	Iron transport intermediates in human reticulocytes and the membrane binding site of iron-transferrin.	Iron	85-89	transferrin	Homo sapiens	90-101
4407032-0	1974	The reticulocyte-mediated release of iron and bicarbonate from transferrin: effect of metabolic inhibitors.	Iron	37-41	transferrin	Homo sapiens	63-74
4843672-0	1974	Transferrin iron, chelatable iron and ferritin in idiopathic haemochromatosis.	Iron	12-16	transferrin	Homo sapiens	0-11
4858430-0	1974	Proceedings: Iron metabolism in X-linked anaemia (sla): effects of the gene during development.	Iron	13-17	Src like adaptor	Homo sapiens	50-53
4811190-0	1974	Biological specificity of the iron-binding sites of transferrin.	Iron	30-34	transferrin	Homo sapiens	52-63
4367301-0	1974	The role of transferrin in iron transport.	Iron	27-31	transferrin	Homo sapiens	12-23
4784877-0	1973	The involvement of bicarbonate in the binding of iron by transferrin.	Iron	49-53	transferrin	Homo sapiens	57-68
4202890-1	1974	Tubercle bacilli failed to grow in iron-void media enriched with solutions of iron-containing transferrin (Tr) or ferritin (F) because these substances do not provide the bacilli with iron, which is essential for their growth.	Iron	78-82	transferrin	Homo sapiens	94-105
4202890-1	1974	Tubercle bacilli failed to grow in iron-void media enriched with solutions of iron-containing transferrin (Tr) or ferritin (F) because these substances do not provide the bacilli with iron, which is essential for their growth.	Iron	78-82	transferrin	Homo sapiens	94-105
4836430-0	1974	The role of heme in the release of iron from transferrin in reticulocytes.	Iron	35-39	transferrin	Homo sapiens	45-56
4779397-0	1973	[Ceruloplasmin activity and the iron-binding capacity of cerebrospinal fluid transferrin in infectious forms of syphilis].	Iron	32-36	transferrin	Homo sapiens	77-88
4699994-0	1973	The effect of heterologous transferrin on the uptake of iron and haem synthesis by bone marrow cells.	Iron	56-60	transferrin	Homo sapiens	27-38
4542821-0	1973	[Alpha 1-antitrypsin deficiency with liver disease and iron overload].	Iron	55-59	serpin family A member 1	Homo sapiens	1-20
4752411-0	1973	The measurement of serum transferrin by iron-binding capacity.	Iron	40-44	transferrin	Homo sapiens	25-36
4752411-1	1973	Two criteria which ought to be satisfied by an acceptable method for the estimation of serum transferrin by iron-binding capacity are enunciated.	Iron	108-112	transferrin	Homo sapiens	93-104
4752411-4	1973	Both methods give results for total iron-binding capacity which are 1-10% high because of the inclusion of non-transferrin iron.	Iron	36-40	transferrin	Homo sapiens	111-122
4759679-2	1973	The transfer of iron from maternal plasma to the foetus was studied in the cat using cat transferrin labelled with (59)Fe and radioiodine.2.	Iron	16-20	transferrin	Homo sapiens	89-100
4759679-9	1973	It was concluded that the maternal endothelium of the placenta of the cat acts as a barrier for the uptake of plasma transferrin-bound iron.	Iron	135-139	transferrin	Homo sapiens	117-128
4726859-0	1973	The significance of transferrin-bound bicarbonate in the uptake of iron by reticulocytes.	Iron	67-71	transferrin	Homo sapiens	20-31
4578897-0	1973	The role of transferrin in iron absorption.	Iron	27-31	transferrin	Homo sapiens	12-23
4511989-2	1973	In acute leukaemia the mean concentration is about ten times the normal level and is associated with a high concentration of transferrin-bound iron.	Iron	143-147	transferrin	Homo sapiens	125-136
4563157-0	1972	The role of transferrin in iron metabolism.	Iron	27-31	transferrin	Homo sapiens	12-23
4511989-3	1973	In Hodgkin"s disease abnormal ferritinaemia is associated with a low concentration of transferrin-bound iron and appears to result from a block of reticuloendothelial iron release.	Iron	104-108	transferrin	Homo sapiens	86-97
4146295-0	1973	Iron-dependent loss of liver cytochrome P-450 haem in vivo and in vitro.	Iron	0-4	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	29-45
4743273-0	1973	[Transferrin saturation with iron in syphilitic lesions of the central nervous system].	Iron	29-33	transferrin	Homo sapiens	1-12
4344989-0	1972	Electron paramagnetic resonance evidence for a distinction between the two iron-binding sites in transferrin and in conalbumin.	Iron	75-79	transferrin	Homo sapiens	97-108
5055384-0	1972	The role of transferrin in the control of iron absorption: studies on a cellular level.	Iron	42-46	transferrin	Homo sapiens	12-23
5046623-0	1972	Serum iron and unsaturated iron-binding capacity in the  -thalassaemia trait: their relation to the levels of haemoglobins A, A 2 , and F.	Iron	6-10	ATPase H+ transporting V0 subunit a2	Homo sapiens	126-129
5037589-0	1972	Route of  59 Fe administration as a factor effecting the sensitivity of an erythropoietin bioassay.	Iron	13-15	erythropoietin	Homo sapiens	75-89
5046623-0	1972	Serum iron and unsaturated iron-binding capacity in the  -thalassaemia trait: their relation to the levels of haemoglobins A, A 2 , and F.	Iron	27-31	ATPase H+ transporting V0 subunit a2	Homo sapiens	126-129
4623711-0	1972	The binding of iron to transferrin and to other serum components at different degrees of saturation with iron.	Iron	15-19	transferrin	Homo sapiens	23-34
5123227-0	1971	The plasma clearance and liver uptake of iron from transferrin of low and high iron saturation.	Iron	41-45	transferrin	Homo sapiens	51-62
5049051-0	1972	The function of amino groups in the binding of iron by transferrin.	Iron	47-51	transferrin	Homo sapiens	55-66
5020353-0	1972	The effect of plasma and transferrin on the hemin inhibition of iron uptake by reticulocytes.	Iron	64-68	transferrin	Homo sapiens	25-36
5058688-0	1972	Circular dichroism of iron, copper, and zinc complexes of transferrin.	Iron	22-26	transferrin	Homo sapiens	58-69
4679287-0	1972	[Evaluation of the blood transferrin-iron ratio as criterion of recovery from viral hepatitis].	Iron	37-41	transferrin	Homo sapiens	25-36
11946389-0	1972	Evidence for pentacoordinated iron (II) in carboxymethylated cytochrome c.	Iron	30-34	cytochrome c, somatic	Homo sapiens	61-73
5144213-3	1971	These results confirmed that saturation of human transferrin with iron alters the conformation sufficiently to produce detectable changes in the hydrodynamic properties.	Iron	66-70	transferrin	Homo sapiens	49-60
5152398-0	1971	[Ceruloplasmin activity and latent transferrin saturation with iron in children with infectious hepatitis].	Iron	63-67	transferrin	Homo sapiens	35-46
5123227-0	1971	The plasma clearance and liver uptake of iron from transferrin of low and high iron saturation.	Iron	79-83	transferrin	Homo sapiens	51-62
5005292-1	1971	Mycobactin (M), an iron-chelating product of tubercle bacilli, neutralized serum tuberculostasis by removing growth-essential iron from transferrin (Tr) and supplying the metal to the bacteria.	Iron	126-130	transferrin	Homo sapiens	136-147
5005292-1	1971	Mycobactin (M), an iron-chelating product of tubercle bacilli, neutralized serum tuberculostasis by removing growth-essential iron from transferrin (Tr) and supplying the metal to the bacteria.	Iron	126-130	transferrin	Homo sapiens	149-151
5005292-2	1971	The competition for iron between Tr and M has been demonstrated by the agar-plate diffusion test.	Iron	20-24	transferrin	Homo sapiens	33-35
5005292-3	1971	This test is suitable not only for the study of Tr-iron-M interplay but also for the evaluation of serum tuberculostasis.	Iron	51-55	transferrin	Homo sapiens	48-50
5117568-6	1971	Total amount of catalase corresponds to 0.12-0.15nmol of haem iron/mg of protein.	Iron	62-66	catalase	Homo sapiens	16-24
5092225-0	1971	New method for determining total iron-binding capacity of serum (TIBC) with radioiron by eliminating iron from transferrin.	Iron	33-37	transferrin	Homo sapiens	111-122
5092225-0	1971	New method for determining total iron-binding capacity of serum (TIBC) with radioiron by eliminating iron from transferrin.	Iron	81-85	transferrin	Homo sapiens	111-122
5571840-0	1971	The preparation of  59 Fe-labelled transferrin for ferrokinetic studies.	Iron	23-25	transferrin	Homo sapiens	35-46
5557835-0	1971	The cellular distribution of transferrin-bound iron in the skin.	Iron	47-51	transferrin	Homo sapiens	29-40
5556118-5	1971	Viable and non-viable tissue slices were incubated in sera treated with radioactive iron so as to produce high and normal levels of transferrin saturation.	Iron	84-88	transferrin	Homo sapiens	132-143
5556118-6	1971	Iron was taken up both from sera with normal and high transferrin saturation but the amount was, in almost all cases, greater from the more highly saturated.	Iron	0-4	transferrin	Homo sapiens	54-65
5535813-0	1970	[A method for the determination of total iron-binding capacity of serum (TIBC) with radioiron by eliminating iron from transferrin].	Iron	41-45	transferrin	Homo sapiens	119-130
5557107-0	1971	A chemical method for the rapid separation of the iron-containing compounds haemosiderin, ferritin, transferrin and haem.	Iron	50-54	transferrin	Homo sapiens	100-111
5490230-0	1970	Is divalent iron bound to transferrin?	Iron	12-16	transferrin	Homo sapiens	26-37
4097651-5	1970	Many of the children died immediately after treatment started, and it is suggested that in children with severe kwashiorkor and low serum transferrin levels any increase in free-circulating iron may result in overwhelming infection and death.	Iron	190-194	transferrin	Homo sapiens	138-149
16558016-2	1971	Tubercle bacilli exposed to an iron-poor medium multiplied at a slower rate but released more of the serum-tuberculostasis neutralizing factor (TNF) than the bacilli in an iron-rich medium.	Iron	31-35	tumor necrosis factor	Homo sapiens	101-142
16558016-2	1971	Tubercle bacilli exposed to an iron-poor medium multiplied at a slower rate but released more of the serum-tuberculostasis neutralizing factor (TNF) than the bacilli in an iron-rich medium.	Iron	31-35	tumor necrosis factor	Homo sapiens	144-147
16558016-6	1971	It was found that the tuberculostasis in mycobactin-neutralized serum was reconstituted by the addition of iron-free transferrin (Tr).	Iron	107-111	transferrin	Homo sapiens	117-128
5480864-1	1970	The importance of ceruloplasmin in iron metabolism was studied in swine made hypoceruloplasminemic by copper deprivation.	Iron	35-39	ceruloplasmin	Sus scrofa	18-31
5480864-2	1970	When the plasma ceruloplasmin level fell below 1% of normal, cell-to-plasma iron flow became sufficiently impaired to cause hypoferremia, even though total body iron stores were normal.	Iron	76-80	ceruloplasmin	Sus scrofa	16-29
5480864-2	1970	When the plasma ceruloplasmin level fell below 1% of normal, cell-to-plasma iron flow became sufficiently impaired to cause hypoferremia, even though total body iron stores were normal.	Iron	161-165	ceruloplasmin	Sus scrofa	16-29
5480864-3	1970	When ceruloplasmin was administered to such animals, plasma iron increased immediately and continued to rise at a rate proportional to the logarithm of the ceruloplasmin dose.	Iron	60-64	ceruloplasmin	Sus scrofa	5-18
5480864-5	1970	Thus, ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma.	Iron	71-75	ceruloplasmin	Sus scrofa	6-19
5480864-7	1970	Retention of injected ferrous iron in the plasma of ceruloplasmin-deficient swine was significantly less than that of ferric iron, reflecting impaired transferrin iron binding.	Iron	30-34	ceruloplasmin	Sus scrofa	52-65
5497445-0	1970	Incorporation of radioactive iron into cytochrome b5 and cytochrome P-450 of liver microsomes.	Iron	29-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-73
5470612-0	1970	[Serum transferrin after oral iron loading].	Iron	30-34	transferrin	Homo sapiens	7-18
5535813-0	1970	[A method for the determination of total iron-binding capacity of serum (TIBC) with radioiron by eliminating iron from transferrin].	Iron	89-93	transferrin	Homo sapiens	119-130
5439730-0	1970	In vivo testing of the Fletcher-Huehns hypothesis of functional differences of iron atoms bound by transferrin.	Iron	79-83	transferrin	Homo sapiens	99-110
5496834-0	1970	[Iron saturation of blood plasma transferrin in with syphilis and gonorrhea].	Iron	1-5	transferrin	Homo sapiens	33-44
5444630-0	1970	Absence of dimers and nature of iron binding in transferrin solutions.	Iron	32-36	transferrin	Homo sapiens	48-59
5446019-2	1970	A comparative study of the utilization of hemoglobin iron and transferrin iron by the erythropoietic tissue.	Iron	74-78	transferrin	Homo sapiens	62-73
5417446-0	1970	Adaptation of the Zak-Epstein automated micromethod for serum iron to determine iron-binding capacity and urinary iron.	Iron	62-66	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	18-21
5469506-0	1970	[The iron saturation of transferrin in eczema and certain other dermatoses].	Iron	5-9	transferrin	Homo sapiens	24-35
5435564-0	1970	Behavior of iron-, indium-, and iodine-labeled transferrin.	Iron	12-16	transferrin	Homo sapiens	47-58
5393666-0	1969	[Atypical transferrin with extremely high serum iron level].	Iron	48-52	transferrin	Homo sapiens	10-21
4250625-0	1970	[Total serum transferrin and iron binding capacity in rats after iron overloads].	Iron	65-69	transferrin	Rattus norvegicus	13-24
5811077-1	1969	In vitro uptake of transferrin-bound iron by rat and rabbit cells.	Iron	37-41	transferrin	Rattus norvegicus	19-30
5365339-0	1969	Effect of sulphydryl inhibition on the uptake of transferrin-bound iron by reticulocytes.	Iron	67-71	transferrin	Homo sapiens	49-60
5365339-1	1969	Iron transferrin, the highly stable carrier of plasma iron, may be dissociated, under physiological conditions, by sodium thioglycollate, a reaction which involves the formation of iron thioglycollate complexes.	Iron	0-4	transferrin	Homo sapiens	5-16
5365339-1	1969	Iron transferrin, the highly stable carrier of plasma iron, may be dissociated, under physiological conditions, by sodium thioglycollate, a reaction which involves the formation of iron thioglycollate complexes.	Iron	54-58	transferrin	Homo sapiens	5-16
5365339-2	1969	This suggested that sulphydryl radicals, which are the active groups in thioglycollate and related compounds, may play a part in the uptake of iron by immature red cells from iron transferrin.	Iron	143-147	transferrin	Homo sapiens	180-191
5365339-2	1969	This suggested that sulphydryl radicals, which are the active groups in thioglycollate and related compounds, may play a part in the uptake of iron by immature red cells from iron transferrin.	Iron	175-179	transferrin	Homo sapiens	180-191
5365339-4	1969	It is demonstrated here that inhibition of uptake of transferrin-bound iron by reticulocytes, which have been exposed to micromolar concentration of p-hydroxymercuribenzoate, is virtually complete.	Iron	71-75	transferrin	Homo sapiens	53-64
4310277-0	1969	Model experiments for the study of iron transfer from transferrin to ferritin.	Iron	35-39	transferrin	Homo sapiens	54-65
5806952-0	1969	[Artificial non-heme-iron proteins from ribonuclease and serum albumin].	Iron	21-25	albumin	Homo sapiens	63-70
5346295-0	1969	Effect of ceruloplasmin on plasma iron in copper-deficient swine.	Iron	34-38	ceruloplasmin	Sus scrofa	10-23
5358992-0	1969	Variation in the availability of transferrin-bound iron for uptake by immature red cells.	Iron	51-55	transferrin	Homo sapiens	33-44
5799023-0	1969	Concerning the proposed existence of a one-iron-protein species of conalbumin or siderophilin.	Iron	43-47	transferrin	Homo sapiens	81-93
17387923-3	1968	The formation of the plutonium-transferrin complex requires the presence of HCO3-, and plutonium is displaced from the complex by excess iron, thus indicating that similar binding sites may be involved in the complexing of iron and plutonium.	Iron	137-141	transferrin	Homo sapiens	31-42
5260911-1	1969	In cytochrome c the axial positions of the heme iron are occupied by two amino acid residues, one of which is known from X-ray studies to be histidyl.	Iron	48-52	cytochrome c, somatic	Homo sapiens	3-15
5784982-1	1969	Twenty-seven specimens of human tissue, obtained by operation, were tested to evaluate the theory that iron uptake by tissues from serum is greater when transferrin is nearly completely saturated than when the degree of saturation is normal.	Iron	103-107	transferrin	Homo sapiens	153-164
5784982-3	1969	In all samples the uptake of iron was greater from the transferrin which was 90% saturated.	Iron	29-33	transferrin	Homo sapiens	55-66
5784982-7	1969	It is concluded that the degree of transferrin saturation is important in determining iron uptake by tissues, especially in those of epithelial origin, and that such uptake may be modified by tissue stores and folic acid deficiency.	Iron	86-90	transferrin	Homo sapiens	35-46
5697365-2	1968	The procedure utilizes (59)Fe to label the apotransferrin with subsequent separation of ionic iron from transferrin-bound iron on an ion exchange or Sephadex G.25 column.	Iron	27-29	transferrin	Homo sapiens	46-57
5794228-0	1969	Fluorescence and absorption studies of the binding of copper and iron to transferrin.	Iron	65-69	transferrin	Homo sapiens	73-84
5781181-0	1969	Rate of release of iron from transferrin to I,10-phenanthroline in vitro.	Iron	19-23	transferrin	Homo sapiens	29-40
4983829-0	1969	[Activity of ceruloplasmin, carbonic anhydrase and saturation of transferrin with iron in blood serum of rats developing experimental sarcoma M-1 against a background of E-avitaminosis].	Iron	82-86	transferrin	Rattus norvegicus	65-76
5709452-0	1968	[Activity of ceruloplasmin and iron saturation of plasma transferrin in children with rheumatism].	Iron	31-35	transferrin	Homo sapiens	57-68
17387923-3	1968	The formation of the plutonium-transferrin complex requires the presence of HCO3-, and plutonium is displaced from the complex by excess iron, thus indicating that similar binding sites may be involved in the complexing of iron and plutonium.	Iron	223-227	transferrin	Homo sapiens	31-42
5657452-8	1968	Isoelectric fractionation of human serum labelled with (59)Fe suggests that the transferrin of normal human serum also exists as metal-free protein, the one-iron-atom-protein complex and the two-iron-atoms-protein complex.	Iron	59-61	transferrin	Homo sapiens	80-91
4886451-0	1968	[The iron and cobalt content of tissues of the organism and the saturation of blood transferrin with iron in patients with nephritis].	Iron	101-105	transferrin	Homo sapiens	84-95
5657452-8	1968	Isoelectric fractionation of human serum labelled with (59)Fe suggests that the transferrin of normal human serum also exists as metal-free protein, the one-iron-atom-protein complex and the two-iron-atoms-protein complex.	Iron	157-161	transferrin	Homo sapiens	80-91
5664904-0	1968	Mossbauer studies of the iron atom in cytochrome c.	Iron	25-29	cytochrome c, somatic	Homo sapiens	38-50
5657452-8	1968	Isoelectric fractionation of human serum labelled with (59)Fe suggests that the transferrin of normal human serum also exists as metal-free protein, the one-iron-atom-protein complex and the two-iron-atoms-protein complex.	Iron	195-199	transferrin	Homo sapiens	80-91
6073027-0	1967	The effect of chemical modification on the iron binding properties of human transferrin.	Iron	43-47	transferrin	Homo sapiens	76-87
4296841-0	1968	An electron paramagnetic resonance study of the iron and copper complexes of transferrin.	Iron	48-52	transferrin	Homo sapiens	77-88
5689515-0	1968	The origin of inorganic sulfide in artificial non-heme iron protein formed from bovine serum albumin.	Iron	55-59	albumin	Homo sapiens	87-100
15938304-0	1967	Influence of transferrin saturation on the effect of intraluminal fructose or histidine on iron absorption.	Iron	91-95	transferrin	Homo sapiens	13-24
4290492-0	1967	Bicarbonate and the binding of iron to transferrin.	Iron	31-35	transferrin	Homo sapiens	39-50
6019400-0	1967	A method of investigating internal iron exchange utilizing two types of transferrin.	Iron	35-39	transferrin	Homo sapiens	72-83
6053479-0	1967	[Influence of alloxan and insulin on the metabolism of iron].	Iron	55-59	insulin	Homo sapiens	26-33
5588046-0	1967	[Effect of erythropoietin on the plasma iron transport].	Iron	40-44	erythropoietin	Homo sapiens	11-25
4173896-0	1967	[Comparative studies on the erythropoietin activity in patients with polycythemia vera and chronic cardiorespiratory insufficiency by means of the determination of radio-iron (Fe59) incorporation].	Iron	170-174	erythropoietin	Homo sapiens	28-42
4967742-0	1968	Immunochemical difference between iron-saturated and unsaturated human transferrin.	Iron	34-38	transferrin	Homo sapiens	71-82
5627848-0	1967	[Autoanalysis of serum iron--evaluation of the Zak-Epstein method].	Iron	23-27	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	47-50
20791302-0	1967	Effect of Total Dose Infusion of Iron-dextran on Iron, Folate, and Vitamin B12 Nutrition in Postpartum Anaemia.	Iron	33-37	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
6050208-0	1967	Significance of the binding of iron by transferrin.	Iron	31-35	transferrin	Homo sapiens	39-50
4951473-2	1967	Iron absorption in rats with carbon tetrachloride (CCl4) induced damage and cirrhosis of the liver.	Iron	0-4	C-C motif chemokine ligand 4	Rattus norvegicus	51-55
5925456-0	1966	Iron absorption in relation to transferrin saturation and other factors.	Iron	0-4	transferrin	Homo sapiens	31-42
5965227-0	1966	On electrophoretic resolution and densitometric determination of apo-transferrin and iron-bound transferrin.	Iron	85-89	transferrin	Homo sapiens	96-107
5945842-0	1966	Studies on the binding of iron to transferrin and conalbumin.	Iron	26-30	transferrin	Homo sapiens	34-45
5935984-0	1966	Changes in plasma transferrin levels following the adminstration of iron.	Iron	68-72	transferrin	Homo sapiens	18-29
14214656-0	1964	EFFECT OF TRANSFERRIN SATURATION ON IRON ABSORPTION IN MAN.	Iron	36-40	transferrin	Homo sapiens	10-21
5927519-0	1966	New methods of identifying serum siderophilin using radioactive iron.	Iron	64-68	transferrin	Homo sapiens	33-45
14324446-0	1965	IRON DEFICIENCY IN RATS: CHANGES IN BODY AND ORGAN WEIGHTS, PLASMA PROTEINS, HEMOGLOBINS, MYOGLOBINS, AND CATALASE.	Iron	0-4	catalase	Rattus norvegicus	106-114
14302489-0	1965	A NEW METHOD OF IDENTIFYING SERUM SIDEROPHILIN BY MEANS OF RADIOACTIVE IRON.	Iron	71-75	transferrin	Homo sapiens	34-46
14235359-0	1964	CLEARANCE OF IRON FROM HEMOCHROMATOTIC AND NORMAL TRANSFERRIN IN VIVO.	Iron	13-17	transferrin	Homo sapiens	50-61
14236554-0	1964	IRON EXCHANGE BETWEEN TRANSFERRIN AND THE PLACENTA IN THE RAT.	Iron	0-4	transferrin	Rattus norvegicus	22-33
14112276-2	1963	The characteristic transferrin pattern of the infants by starch gel electrophoresis contained a single prominent iron-binding component accompanied by 4 faint, slower migrating components.	Iron	113-117	transferrin	Homo sapiens	19-30
14323195-0	1964	[THE EFFECT OF ERYTHROPOIETIN CONCENTRATE ON THE IRON INCORPORATION BY NUCLEATED ERYTHROCYTES IN VITRO].	Iron	49-53	erythropoietin	Homo sapiens	15-29
14215965-2	1964	The effects on growth of chelator-iron ratios in the range 25 to 400 muM were studied in relation to Ca, heavy metal concentrations, and incubation time.	Iron	34-38	latexin	Homo sapiens	69-72
14138175-0	1964	[CONTRIBUTION TO THE STUDY OF THE DETERMINATION OF THE CAPACITY OF IRON FIXATION BY SIDEROPHILIN].	Iron	67-71	transferrin	Homo sapiens	84-96
14073162-2	1963	EFFECT OF ERYTHROPOIETIN AND IRON ON CELL SIZE IN IRON DEFICIENCY ANEMIA.	Iron	50-54	erythropoietin	Homo sapiens	10-24
14076129-0	1963	STUDIES ON THE EXCHANGE OF IRON BETWEEN TRANSFERRIN AND RETICULOCYTES.	Iron	27-31	transferrin	Homo sapiens	40-51
14024217-0	1963	[The role of transferrin in the intestinal absorption of Fe-59 of rats.	Iron	57-59	transferrin	Rattus norvegicus	13-24
14000226-0	1963	Role of transferrin in iron absorption.	Iron	23-27	transferrin	Homo sapiens	8-19
14483936-3	1962	The presence of a faint iron-binding component which migrates slightly more rapidly than the principal transferrin with which it is associated is also described.	Iron	24-28	transferrin	Homo sapiens	103-114
13976694-0	1962	[Rapid method of determining the iron-saturation capacity of transferrin in the serum].	Iron	33-37	transferrin	Homo sapiens	61-72
13890698-0	1962	Effect of erythropoietin on the uptake and utilization of iron by bone marrow cells in vitro.	Iron	58-62	erythropoietin	Homo sapiens	10-24
13908279-7	1962	Carbonyl iron spherules, Diplococcus pneumoniae types IIs and XXVIIs, and Serratia marcescens were phagocytosed more rapidly and in greater numbers by leukocytes of normal human blood after incubation with C-reactive protein.	Iron	9-13	C-reactive protein	Homo sapiens	206-224
14497367-0	1962	Estimation of haptoglobin using haemoglobin labelled with radioactive iron-59.	Iron	70-74	haptoglobin	Homo sapiens	14-25
13883045-0	1961	[Transferrin level following oral iron therapy].	Iron	34-38	transferrin	Homo sapiens	1-12
14454385-0	1961	Iron and protein kinetics studied by means of doubly labeled human crystalline transferrin.	Iron	0-4	transferrin	Homo sapiens	79-90
13866116-1	1961	Rapid methods depending on differential absorptiometry are described for the determination of the transferrin iron content and the latent iron-binding capacity of blood serum.	Iron	110-114	transferrin	Homo sapiens	98-109
13778706-0	1961	The binding and transport of iron by transferrin variants.	Iron	29-33	transferrin	Homo sapiens	37-48
13786614-0	1961	Immunological precipitin titrations based on radioactive tagging of the iron naturally chelated by the proteins siderophilin and conalbumin.	Iron	72-76	transferrin	Homo sapiens	112-124
14451094-0	1961	The plasma-to-cell cycle of transferrin in iron utilization.	Iron	43-47	transferrin	Homo sapiens	28-39
13665996-0	1959	Serum iron-binding protein levels after infusion of human serum-albumin; possible control mechanism for serum-protein formation.	Iron	6-10	albumin	Homo sapiens	58-71
13771333-0	1960	Lowering of transferrin during iron absorption in iron deficiency.	Iron	31-35	transferrin	Homo sapiens	12-23
13675199-0	1959	Effects of ACTH on plasma iron levels in normal human subjects.	Iron	26-30	proopiomelanocortin	Homo sapiens	11-15
13287947-0	1955	[Iron content of human milk, human colostrum and cow"s milk].	Iron	1-5	Weaning weight-maternal milk	Bos taurus	23-27
13287947-0	1955	[Iron content of human milk, human colostrum and cow"s milk].	Iron	1-5	Weaning weight-maternal milk	Bos taurus	55-59
13172260-0	1954	The function of inorganic iron in the reduction of cytochrome C.	Iron	26-30	cytochrome c, somatic	Homo sapiens	51-63
13271587-0	1955	The demonstration of the iron-binding globulin (transferrin) in serum and urine proteins by use of 59Fe combined with paper electrophoresis.	Iron	25-29	transferrin	Homo sapiens	48-59
13277193-0	1955	[Reduction of NO-3 ions to NO-2 and NH+4 ions by iron in corrosive tropical water].	Iron	49-53	NBL1, DAN family BMP antagonist	Homo sapiens	14-18
13059139-0	1952	[Changes in transferrin following the administration of iron preparations in normal children and those with blood disorders].	Iron	56-60	transferrin	Homo sapiens	12-23
13156478-0	1954	[Clinical studies of variations of blood iron and of digestive absorption of iron under the influence of ACTH and cortisone].	Iron	41-45	proopiomelanocortin	Homo sapiens	105-109
13156478-0	1954	[Clinical studies of variations of blood iron and of digestive absorption of iron under the influence of ACTH and cortisone].	Iron	77-81	proopiomelanocortin	Homo sapiens	105-109
13106045-0	1953	[Research on the ACTH-induced variations in blood iron in relation to the uric acid and creatinine content and the eosinophil count of the blood].	Iron	50-54	proopiomelanocortin	Homo sapiens	17-21
17809382-0	1950	Studies on the Metabolism of Administered Cytochrome C by the Aid of Iron-labeled Cytochrome.	Iron	69-73	cytochrome c, somatic	Homo sapiens	42-54
18887891-0	1948	On the nature of iron binding by siderophilin, conlbumin, hydroxylamine, aspergillic acid, and related hydroxamic acids.	Iron	17-21	transferrin	Homo sapiens	33-45
18104411-0	1949	On the mode of iron binding by siderophilin, conalbumin, hydroxylamine, aspergillic acid, and other hydroxamic acids.	Iron	15-19	transferrin	Homo sapiens	31-43
17783358-0	1948	Cytochrome C Labeled With Radioactive Iron.	Iron	38-42	cytochrome c, somatic	Homo sapiens	0-12
33662150-12	2021	Together, Nanog expression appears related to poor prognosis in esophageal cancer patients, and inhibition of stemness and compensatory IL-6 secretion by iron chelators may offer a novel therapeutic strategy for esophageal cancer.	Iron	154-158	interleukin 6	Homo sapiens	136-140
19873017-12	1937	Hydrazine or pyridine and hydrosulfite convert catalase into hemochromogens containing ferrous iron.	Iron	95-99	catalase	Homo sapiens	47-55
18122269-0	1949	Carbon dioxide and oxygen in complex formation with iron and siderophilin, the iron-binding component of human plasma.	Iron	79-83	transferrin	Homo sapiens	61-73
29011891-0	1939	Ionisable Iron in Cows" and Mothers" Milk.	Iron	10-14	Weaning weight-maternal milk	Bos taurus	37-41
33901579-0	2021	Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2alpha/ATF4/CHOP pathway in vitro.	Iron	0-4	activating transcription factor 4	Mus musculus	127-131
33901579-11	2021	In conclusion, our finding suggested that iron overload induced apoptosis via eliciting ER stress, which resulted in mitochondrial dysfunction and activated p-eIF2alpha/ATF4/CHOP pathway.	Iron	42-46	activating transcription factor 4	Mus musculus	169-173
33743405-11	2021	Urinary Ni, Cu, and Fe levels were associated with an increase in urinary IL-6 and a decrease in urinary cortisol among workers.	Iron	20-22	interleukin 6	Homo sapiens	74-78
33872694-6	2021	Silence of SIRT3 gene also suppressed AKT-dependent ferroptosis, an iron-dependent and lipid peroxide-mediated cell death.	Iron	68-72	sirtuin 3	Homo sapiens	11-16
33930800-0	2021	A case series highlighting structured hematological, biochemical and molecular approach to clinical oral iron refractoriness in children: A pressing need for a 3-tier system for classification of variants in TMPRSS6 gene.	Iron	105-109	transmembrane serine protease 6	Homo sapiens	208-215
33878610-5	2021	Furthermore, dioscin induced ferroptosis by affecting the expression of transferrin and ferroportin which are regulators of intracellular levels of iron.	Iron	148-152	transferrin	Homo sapiens	72-83
33988981-7	2021	For the first time, we present a cocrystal structure of SAMHD1 with a substrate, Rp-dGTPalphaS, in which an Fe-Mg-bridging water species is poised for nucleophilic attack on the Palpha.	Iron	108-110	ultraconserved element uc.328	Homo sapiens	87-93
33432609-0	2021	Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells.	Iron	0-4	forkhead box O1	Homo sapiens	64-69
33432609-0	2021	Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells.	Iron	0-4	adiponectin, C1Q and collagen domain containing	Homo sapiens	22-33
33677206-2	2021	Binding of flavonoids to HST produces changes in the protein structure with direct implication on iron delivery into cells.	Iron	98-102	fibroblast growth factor 4	Homo sapiens	25-28
33930515-0	2021	Iron-binding cellular profile of transferrin using label-free Raman hyperspectral imaging and singular value decomposition (SVD).	Iron	0-4	transferrin	Homo sapiens	33-44
33870657-2	2021	Here, we report the environmental concentrations of rhodopsin along the Subtropical Frontal Zone off New Zealand, where Subtropical waters encounter the iron-limited Subantarctic High Nutrient Low Chlorophyll (HNLC) region.	Iron	23-27	rhodopsin	Homo sapiens	52-61
33930515-2	2021	Transferrin is responsible for the sequestration of free iron in serum and the delivery of iron throughout the body and into cells, where iron is released inside a mildly acidified endosome.	Iron	57-61	transferrin	Homo sapiens	0-11
33930515-2	2021	Transferrin is responsible for the sequestration of free iron in serum and the delivery of iron throughout the body and into cells, where iron is released inside a mildly acidified endosome.	Iron	91-95	transferrin	Homo sapiens	0-11
33930515-2	2021	Transferrin is responsible for the sequestration of free iron in serum and the delivery of iron throughout the body and into cells, where iron is released inside a mildly acidified endosome.	Iron	91-95	transferrin	Homo sapiens	0-11
33930515-10	2021	We demonstrate the strength of the SVD method to monitor pH-induced Tf iron-release using Raman hyperspectral imaging, providing the redox biology field with a novel tool that facilitates subcellular investigation of the iron-binding profile of transferrin in various disease models.	Iron	221-225	transferrin	Homo sapiens	245-256
33985732-4	2021	O2 and NO3- could promote the photochemical release of DOM and Fe, especially during the initial 4 h irradiation.	Iron	63-65	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
33892380-5	2021	We solved the "Lys-off" X-ray structure of THB1, represented by the cyanide adduct of the Fe(III) protein, and hypothesized that interactions that differ between the known "Lys-on" structure and the Lys-off structure participate in the control of Lys53 affinity for the heme iron.	Iron	275-279	uncharacterized protein	Chlamydomonas reinhardtii	43-47
33985732-5	2021	In general, the order of the photorelease rates of DOM and Fe under different conditions was as follows: NO3-/aerobic > aerobic   NO3-/anaerobic > anaerobic.	Iron	59-61	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
33985732-5	2021	In general, the order of the photorelease rates of DOM and Fe under different conditions was as follows: NO3-/aerobic > aerobic   NO3-/anaerobic > anaerobic.	Iron	59-61	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
33836297-1	2021	To reveal the role of ferrate self-decomposition and the fates of intermediate iron species [Fe(V)/Fe(IV) species] during ferrate oxidation, the reaction between ferrate and methyl phenyl sulfoxide (PMSO) at pH 7.0 was investigated as a model system in this study.	Iron	79-83	FEV transcription factor, ETS family member	Homo sapiens	93-98
33686292-4	2021	From this dataset we identify dozens of ferroptosis suppressors, including numerous compounds that appear to act via cryptic off-target antioxidant or iron chelating activities.	Iron	151-155	cripto, FRL-1, cryptic family 1	Homo sapiens	117-124
33657279-6	2021	RESULTS: After adjustment for gestational age at maternal iron status measurement and sociodemographic or lifestyle-related confounders, a higher maternal transferrin concentration was associated with a higher risk of physician-diagnosed inhalant allergy (odds ratio [95% confidence interval]: 1.13 [1.01 to1.26]), but not with lung function, asthma, or inhalant allergic sensitization.	Iron	58-62	transferrin	Homo sapiens	155-166
33657279-9	2021	CONCLUSION: Higher maternal transferrin concentrations during pregnancy, reflecting lower serum iron levels, were associated with an increased risk of child"s physician-diagnosed inhalant allergy but not lung outcomes.	Iron	96-100	transferrin	Homo sapiens	28-39
33540164-2	2021	In this study, an effective advanced oxidation technique using zero-valent iron powder (Fe0)-activated persulfate (PS) was used for the degradation of BP-1.	Iron	75-79	BP1	Homo sapiens	151-155
33479526-4	2021	Initial lithiation of FeF3 forms FeF2 on the particle"s surface, along with a cation-ordered and stacking-disordered phase, A-LixFeyF3, which is structurally related to alpha-/beta-LiMn2+Fe3+F6 and which topotactically transforms to B- and then C-LixFeyF3, before forming LiF and Fe.	Iron	22-24	amyloid beta precursor protein	Homo sapiens	5-6
33479526-4	2021	Initial lithiation of FeF3 forms FeF2 on the particle"s surface, along with a cation-ordered and stacking-disordered phase, A-LixFeyF3, which is structurally related to alpha-/beta-LiMn2+Fe3+F6 and which topotactically transforms to B- and then C-LixFeyF3, before forming LiF and Fe.	Iron	22-24	amyloid beta precursor protein	Homo sapiens	169-180
34050579-7	2021	Lower serum ferritin (indicating depleted body iron stores) was related to higher EPO observed/predicted ratio when adjusted for significant clinical confounders, including C-reactive protein.	Iron	47-51	erythropoietin	Homo sapiens	82-85
34043061-1	2021	Pathogenic variants in the WDR45 (OMIM: 300,526) gene on chromosome Xp11 are the genetic cause of a rare neurological disorder characterized by increased iron deposition in the basal ganglia.	Iron	154-158	WD repeat domain 45	Mus musculus	27-32
34058232-7	2021	The ability of SAA to inhibit apoptosis, increase nuclear Nrf2 expression, and decrease nuclear NF-kappaB expression was further confirmed in the retinas of iron-overloaded mice.	Iron	157-161	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
34057084-3	2021	Previous studies mostly associated copper, iron, zinc, and calcium with ApoE4-mediated toxicity.	Iron	43-47	apolipoprotein E	Homo sapiens	72-77
34002353-14	2021	They were menaquinone-dependent protoporphyrinogen oxidase pattern enhanced in the former and both 3",5"-cyclic-nucleotide phosphodiesterase (purine metabolism) and iron(III) transport system ATP-binding protein enhanced in the latter.	Iron	165-169	protoporphyrinogen oxidase	Homo sapiens	32-58
34036507-9	2021	Our results showed a negative association between the alterations in E-cadherin and total elemental components in correlation analysis, especially S, Cl, K, Ti, Mn, Fe, Cu, Zn, and Pb.	Iron	165-167	cadherin 1	Homo sapiens	69-79
34034544-9	2022	Likewise, decreased expression of Tfrc and Slc40a1, both of which are crucial proteins for iron transportation, was observed in Lif-/- mice and Lif-knockdown ameloblast lineage cell lines, according to quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot.	Iron	91-95	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	43-50
34039609-3	2021	Iron-responsive element-binding proteins IRP1 and IRP2 posttranscriptionally regulate iron homeostasis.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	50-54
34039609-3	2021	Iron-responsive element-binding proteins IRP1 and IRP2 posttranscriptionally regulate iron homeostasis.	Iron	86-90	iron responsive element binding protein 2	Homo sapiens	50-54
34039609-8	2021	Deletion of both IRP1 and IRP2 abolishes the iron-starvation response, preventing its activation by ISC synthesis inhibition.	Iron	45-49	iron responsive element binding protein 2	Homo sapiens	26-30
33891408-6	2021	Impressively, pouch cells fabricated with the Fe-Ni/S cathodes achieve stable cycling performance under practically necessary conditions with a low electrolyte/sulfur (E/S) ratio of 4.5 muL mg-1.	Iron	46-48	solute carrier family 5 member 5	Homo sapiens	49-53
34030724-0	2021	Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson"s disease.	Iron	65-69	parkinson protein 7	Danio rerio	8-13
34041460-11	2021	Patients with severe preoperative anemia given iron preoperatively had lower intra/post-operative RBC transfusion rate, shorter length of stay and less hospitalization costs, but no similar correlation was found in patients with mild and moderate preoperative anemia and patients given erythropoietin preoperatively.	Iron	47-51	erythropoietin	Homo sapiens	286-300
33876811-5	2021	Nevertheless, excessive iron in adipose tissue leads to decreased insulin sensitivity owing to mitochondrial dysfunction and adipokine changes.	Iron	24-28	insulin	Homo sapiens	66-73
34003408-6	2021	Iron speciation revealed a significant increase in serum transferrin-bound iron and reduced ferritin-bound Fe levels.	Iron	0-4	transferrin	Rattus norvegicus	57-68
34003408-6	2021	Iron speciation revealed a significant increase in serum transferrin-bound iron and reduced ferritin-bound Fe levels.	Iron	75-79	transferrin	Rattus norvegicus	57-68
34051234-4	2021	Here we investigated the role of metal transporters SLC39A14 and SLC30A10 in biliary iron excretion.	Iron	85-89	solute carrier family 30, member 10	Mus musculus	65-73
34051234-7	2021	We hypothesized that biliary excretion of excess iron would be impaired by SLC39A14 and SLC30A10 deficiency.	Iron	49-53	solute carrier family 30, member 10	Mus musculus	88-96
34028595-5	2021	In addition, an inhibitory effect of Cd, Pb, As, and Fe on SIRT3 has been demonstrated.	Iron	53-55	sirtuin 3	Homo sapiens	59-64
34018302-0	2021	The phyB-dependent induction of HY5 promotes iron uptake by systemically activating FER expression.	Iron	45-49	phytochrome B2	Solanum lycopersicum	4-8
34018302-3	2021	Here, we find that light-induced Fe uptake in tomato (Solanum lycopersicum L.) is largely dependent on phytochrome B (phyB).	Iron	33-35	phytochrome B2	Solanum lycopersicum	103-116
34018302-3	2021	Here, we find that light-induced Fe uptake in tomato (Solanum lycopersicum L.) is largely dependent on phytochrome B (phyB).	Iron	33-35	phytochrome B2	Solanum lycopersicum	118-122
34018302-7	2021	The low Fe uptake observed in phyB, hy5, and fer mutants is accompanied by lower photosynthetic electron transport rates.	Iron	8-10	phytochrome B2	Solanum lycopersicum	30-34
34018302-9	2021	Taken together, these results demonstrate that Fe uptake is systemically regulated by light in a phyB-HY5-FER-dependent manner.	Iron	47-49	phytochrome B2	Solanum lycopersicum	97-101
34008401-1	2021	Cysteine dioxygenase (CDO) is a nonheme mononuclear iron enzyme, which catalyzes the oxidation of cysteine to cysteine sulfinic acid.	Iron	52-56	cell adhesion associated, oncogene regulated	Homo sapiens	22-25
34008401-7	2021	In F2-CDO, the cofactor formation contains the H-abstraction, C-S bond formation, intramolecular F migration, and aromatization of the residue F2Y157, in which the Fe-coordinate dioxygen can be recovered after the formation cofactor; however, in the WT-CDO, the cofactor formation shows some differences.	Iron	164-166	cell adhesion associated, oncogene regulated	Homo sapiens	3-9
34008401-7	2021	In F2-CDO, the cofactor formation contains the H-abstraction, C-S bond formation, intramolecular F migration, and aromatization of the residue F2Y157, in which the Fe-coordinate dioxygen can be recovered after the formation cofactor; however, in the WT-CDO, the cofactor formation shows some differences.	Iron	164-166	cell adhesion associated, oncogene regulated	Homo sapiens	6-9
34004015-4	2022	A number of novel approaches to correct the resulting alpha/beta globin chain imbalance, treat ineffective erythropoiesis and improve iron overload are currently being developed.	Iron	134-138	amyloid beta precursor protein	Homo sapiens	54-64
34004015-4	2022	A number of novel approaches to correct the resulting alpha/beta globin chain imbalance, treat ineffective erythropoiesis and improve iron overload are currently being developed.	Iron	134-138	amyloid beta precursor protein	Homo sapiens	0-1
34015760-6	2021	The results indicated that RSL3 induced cell death, mitochondrial dysfunction, ROS production, and iron ion accumulation in melanocytes, which was aggravated by the addition of FAC.	Iron	99-103	FA complementation group C	Homo sapiens	177-180
34002695-1	2021	Background: Erythroblast erythroferrone (ERFE) secretion inhibits hepcidin expression by sequestering several bone morphogenetic protein (BMP) family members to increase iron availability for erythropoiesis.	Iron	170-174	erythroferrone	Mus musculus	41-45
34002881-2	2021	PKAN is caused by genetic variants in the PANK2 gene that result in dysfunction in pantothenate kinase 2 (PANK2) enzyme activity, with consequent disruption of coenzyme A (CoA) synthesis, and subsequent accumulation of brain iron.	Iron	225-229	pantothenate kinase 2	Homo sapiens	0-4
34002881-2	2021	PKAN is caused by genetic variants in the PANK2 gene that result in dysfunction in pantothenate kinase 2 (PANK2) enzyme activity, with consequent disruption of coenzyme A (CoA) synthesis, and subsequent accumulation of brain iron.	Iron	225-229	pantothenate kinase 2	Homo sapiens	42-47
34002881-2	2021	PKAN is caused by genetic variants in the PANK2 gene that result in dysfunction in pantothenate kinase 2 (PANK2) enzyme activity, with consequent disruption of coenzyme A (CoA) synthesis, and subsequent accumulation of brain iron.	Iron	225-229	pantothenate kinase 2	Homo sapiens	83-104
34002881-2	2021	PKAN is caused by genetic variants in the PANK2 gene that result in dysfunction in pantothenate kinase 2 (PANK2) enzyme activity, with consequent disruption of coenzyme A (CoA) synthesis, and subsequent accumulation of brain iron.	Iron	225-229	pantothenate kinase 2	Homo sapiens	106-111
34008404-0	2021	Stereospecific Iron-Catalyzed Carbon (sp2)-Carbon (sp2) Cross-Coupling of Aryllithium with Vinyl Halides.	Iron	15-19	Sp2 transcription factor	Homo sapiens	38-41
34008404-0	2021	Stereospecific Iron-Catalyzed Carbon (sp2)-Carbon (sp2) Cross-Coupling of Aryllithium with Vinyl Halides.	Iron	15-19	Sp2 transcription factor	Homo sapiens	51-54
33932034-0	2021	BNIP3 promotes HIF-1alpha-driven melanoma growth by curbing intracellular iron homeostasis.	Iron	74-78	BCL2 interacting protein 3	Homo sapiens	0-5
33932034-0	2021	BNIP3 promotes HIF-1alpha-driven melanoma growth by curbing intracellular iron homeostasis.	Iron	74-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-25
33932034-4	2021	Mechanistically, we found that BNIP3-deprived melanoma cells displayed increased intracellular iron levels caused by heightened NCOA4-mediated ferritinophagy, which fostered PHD2-mediated HIF-1alpha destabilization.	Iron	95-99	egl-9 family hypoxia inducible factor 1	Homo sapiens	174-178
34015471-3	2021	The TA-Fe@MNPs synthesized via a simple coordination of Fe3+ with TA, bovine serum albumin, and polyethyleneimine under ambient conditions exhibited an appropriate size (~125 nm), electrically neutral surfaces, good biocompatibility, and low normal cell toxicity.	Iron	7-9	albumin	Homo sapiens	77-90
33929185-3	2021	We report herein a mild and versatile synthetic access to the 1,4-dihydropentalene framework enabled by iron-catalyzed single-pot tandem cyclization of a diarylacetylene using FeCl2 and PPh3 as catalyst, magnesium/LiCl as a reductant, and 1,2-dichloropropane as a mild oxidant.	Iron	104-108	caveolin 1	Homo sapiens	186-190
34022567-11	2021	Several genes of iron metabolism presented a higher expression in DIOS vs MetS: SCL11A2 (a free iron transporter, +76 %, p = 0.04), SOD1 (an antioxidant enzyme, +27 %, p = 0.02), and TFRC (the receptor 1 of transferrin, +59 %, p = 0.003).	Iron	17-21	superoxide dismutase 1	Homo sapiens	132-136
34022567-11	2021	Several genes of iron metabolism presented a higher expression in DIOS vs MetS: SCL11A2 (a free iron transporter, +76 %, p = 0.04), SOD1 (an antioxidant enzyme, +27 %, p = 0.02), and TFRC (the receptor 1 of transferrin, +59 %, p = 0.003).	Iron	17-21	transferrin	Homo sapiens	207-218
34055782-0	2021	JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration.	Iron	25-29	fibronectin 1	Homo sapiens	66-77
33982118-2	2021	Iron homeostasis is influenced by 3 regulatory hormones: erythropoietin (EPO), hepcidin, and erythroferrone (ERFE).	Iron	0-4	erythropoietin	Homo sapiens	57-71
33982118-2	2021	Iron homeostasis is influenced by 3 regulatory hormones: erythropoietin (EPO), hepcidin, and erythroferrone (ERFE).	Iron	0-4	erythropoietin	Homo sapiens	73-76
33982118-9	2021	Of all hormones measured at midgestation and delivery, EPO was best able to identify women with anemia (AUC: 0.86 and 0.75, respectively) and depleted iron stores (AUC: 0.77 and 0.84), whereas the hepcidin-to-EPO ratio was best able to identify women with iron deficiency anemia (AUC: 0.85 and 0.84).	Iron	151-155	erythropoietin	Homo sapiens	55-58
34004477-8	2021	gamma-Fe2O3 and Fe3O4 NPs could also cause mitochondrial fusion and fission dysregulation, activate lipid peroxidation and iron metabolism-related genes in a P53-dependent manner.	Iron	123-127	tumor protein p53	Homo sapiens	158-161
33980305-11	2021	Prussian blue staining and TEM showed a large amount of iron particles in MTMSCs-PEG3-FTH1 but a minimal amount in MSCs-PEG3-FTH1.	Iron	56-60	paternally expressed 3	Mus musculus	81-85
33969609-6	2021	Additionally, the non-lethal doses of etoposide and cisplatin can induce SCLC cell stemness in a concentration-dependent manner and reduce the lysosome iron concentration dependent on Ferritin expression, which is positively regulated by HIF-1alpha/beta.	Iron	152-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	238-253
33693820-11	2021	Proteins translated from iron-responsive element (IRE)-containing mRNA were altered in abundance; ferritin and ferroportin 1 decreased, while TFRC increased in ID placentas.	Iron	25-29	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	111-124
33982327-2	2021	Growth factors, such as BMP2, BMP6 and TGFbeta1, are released from liver sinusoidal endothelial cells (LSECs) and signal in a paracrine manner to hepatocytes and hepatic stellate cells to control systemic iron homeostasis and fibrotic processes, respectively.	Iron	205-209	bone morphogenetic protein 2	Mus musculus	24-28
33970200-1	2021	Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-containing non-heme oxygenase of unknown specificity and biological significance.	Iron	68-72	4-hydroxyphenylpyruvate dioxygenase like	Homo sapiens	6-46
33982327-3	2021	The misregulation of the TGFbeta/BMP pathway affects expression of the iron-regulated hormone hepcidin causing frequent iron overload and deficiency diseases.	Iron	71-75	bone morphogenetic protein 2	Mus musculus	33-36
33982327-3	2021	The misregulation of the TGFbeta/BMP pathway affects expression of the iron-regulated hormone hepcidin causing frequent iron overload and deficiency diseases.	Iron	120-124	bone morphogenetic protein 2	Mus musculus	33-36
33982327-9	2021	CONCLUSIONS: These findings reveal that TGFbeta1 signalling is functionally interlinked with BMP signalling in LSECs suggesting new druggable targets for the treatment of iron overload diseases associated with deficiency of the BMP2-regulated hormone hepcidin, such as Hereditary Hemochromatosis, beta-thalassemia and chronic liver diseases.	Iron	171-175	bone morphogenetic protein 2	Mus musculus	93-96
33970200-1	2021	Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-containing non-heme oxygenase of unknown specificity and biological significance.	Iron	68-72	4-hydroxyphenylpyruvate dioxygenase like	Homo sapiens	48-52
33982327-9	2021	CONCLUSIONS: These findings reveal that TGFbeta1 signalling is functionally interlinked with BMP signalling in LSECs suggesting new druggable targets for the treatment of iron overload diseases associated with deficiency of the BMP2-regulated hormone hepcidin, such as Hereditary Hemochromatosis, beta-thalassemia and chronic liver diseases.	Iron	171-175	bone morphogenetic protein 2	Mus musculus	228-232
33962944-5	2021	Mechanistically, miR-210 induction in activated macrophages supported a switch toward a proinflammatory state by lessening mitochondria respiration in favor of glycolysis, partly achieved by downmodulating the iron-sulfur cluster assembly enzyme ISCU.	Iron	210-214	microRNA 210	Mus musculus	17-24
33582440-2	2021	Holo-transferrin is a blood-plasma glycoprotein whose main function is iron-binding and the transport of other ligands.	Iron	71-75	transferrin	Homo sapiens	5-16
33956021-0	2021	A highly efficient Fe-Ni-S/NF hybrid electrode for promoting oxygen evolution performance.	Iron	19-21	solute carrier family 5 member 5	Homo sapiens	22-26
33953171-3	2021	Although mitochondrial ferritin (FtMt) plays a critical role in iron homeostasis, the molecular function of FtMt in I/R remains unknown.	Iron	64-68	ferritin mitochondrial	Mus musculus	33-37
33953171-7	2021	Further investigation shows that Ftmt ablation promotes I/R-induced inflammation and hepcidin-mediated decreases in ferroportin1, thus markedly increasing total and chelatable iron.	Iron	176-180	ferritin mitochondrial	Mus musculus	33-37
34012978-6	2021	The intracellular iron content was increased in cells overexpressing TfRC or mutant WDR45, however, ferritin H (FTH) chain was decreased.	Iron	18-22	WD repeat domain 45	Homo sapiens	84-89
34012440-8	2021	Results: Iron impaired microglial function in vitro regarding phagocytosis and markers of inflammation; this was regulated by clozapine, reflected in reduced release of IL-6 and normalization of neuronal phagocytosis.	Iron	9-13	interleukin 6	Homo sapiens	169-173
34012978-8	2021	Taken together, these findings provide a piece of important evidence that WDR45 deficiency impairs autophagic degradation of TfRC, therefore leading to iron accumulation, and the elevated iron promotes ferroptosis which may contribute to the progression of BPAN.	Iron	152-156	WD repeat domain 45	Homo sapiens	74-79
33941809-0	2021	Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning.	Iron	12-16	renin binding protein	Homo sapiens	0-3
33676025-5	2021	We identified four calcium-dependent protein kinases, CPK4/5/6/11, interacting with the tonoplast-localized Mn and iron (Fe) transporter MTP8 in vitro and in vivo.	Iron	115-119	calcium-dependent protein kinase 4	Arabidopsis thaliana	54-65
33676025-5	2021	We identified four calcium-dependent protein kinases, CPK4/5/6/11, interacting with the tonoplast-localized Mn and iron (Fe) transporter MTP8 in vitro and in vivo.	Iron	121-123	calcium-dependent protein kinase 4	Arabidopsis thaliana	54-65
33941809-3	2021	However, the specificity of age-related iron increases with respect to cognitive functions remains unclear.	Iron	40-44	renin binding protein	Homo sapiens	28-31
33941809-10	2021	Our results suggest that age-related increases in iron and demyelination within the BG, which are part of a fronto-striatal network, not only impact on verbal memory but also executive functions.	Iron	50-54	renin binding protein	Homo sapiens	25-28
34014775-9	2021	Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha.	Iron	8-10	tumor necrosis factor	Homo sapiens	99-108
33938061-4	2021	Here, we report a novel fluorogen directly engineered from green fluorescent protein (GFP) chromophore by a unique double-donor-one-acceptor strategy, which exhibits an over 550-fold FE upon FAST binding and a high extinction coefficient of ~100,000 M -1  cm -1 .	Iron	183-185	Fas activated serine/threonine kinase	Homo sapiens	191-195
33323945-5	2021	We have previously demonstrated that the Transferrin/Transferrin Receptor 2 (TfR2) iron import mechanism functions in nigral dopaminergic neurons, is perturbed in PD models and patients, and therefore constitutes a potential therapeutic target to halt iron accumulation.	Iron	83-87	transferrin	Homo sapiens	41-52
33323945-5	2021	We have previously demonstrated that the Transferrin/Transferrin Receptor 2 (TfR2) iron import mechanism functions in nigral dopaminergic neurons, is perturbed in PD models and patients, and therefore constitutes a potential therapeutic target to halt iron accumulation.	Iron	252-256	transferrin	Homo sapiens	41-52
33711329-0	2021	Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.	Iron	47-51	solute carrier family 25, member 28	Mus musculus	0-12
33711329-3	2021	Mitoferrin 2 (Mfrn2) is an iron transporter in the inner mitochondrial membrane.	Iron	27-31	solute carrier family 25, member 28	Mus musculus	0-12
33711329-3	2021	Mitoferrin 2 (Mfrn2) is an iron transporter in the inner mitochondrial membrane.	Iron	27-31	solute carrier family 25, member 28	Mus musculus	14-19
33711329-6	2021	Mfrn2 gene silencing inhibited mitochondrial iron overload, stabilized mitochondrial membrane potential and improved mitochondrial function in TNF-alpha-induced MAECs.	Iron	45-49	solute carrier family 25, member 28	Mus musculus	0-5
33711329-8	2021	Furthermore, TNF-alpha increased the binding of 14-3-3 epsilon (epsilon) and Mfrn2, preventing Mfrn2 degradation and leading to mitochondrial iron overload in ECs, while 14-3-3epsilon overexpression increased Mfrn2 stability by inhibiting its ubiquitination.	Iron	142-146	tumor necrosis factor	Mus musculus	13-22
33711329-8	2021	Furthermore, TNF-alpha increased the binding of 14-3-3 epsilon (epsilon) and Mfrn2, preventing Mfrn2 degradation and leading to mitochondrial iron overload in ECs, while 14-3-3epsilon overexpression increased Mfrn2 stability by inhibiting its ubiquitination.	Iron	142-146	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	Mus musculus	48-62
33711329-8	2021	Furthermore, TNF-alpha increased the binding of 14-3-3 epsilon (epsilon) and Mfrn2, preventing Mfrn2 degradation and leading to mitochondrial iron overload in ECs, while 14-3-3epsilon overexpression increased Mfrn2 stability by inhibiting its ubiquitination.	Iron	142-146	solute carrier family 25, member 28	Mus musculus	77-82
33711329-9	2021	Together, our results reveal that Mfrn2 deficiency attenuates endothelial dysfunction by decreasing iron levels within the mitochondria and mitochondrial dysfunction.	Iron	100-104	solute carrier family 25, member 28	Mus musculus	34-39
33827043-10	2021	Mechanistically, SGNI induced ferroptosis was dependent on HO-1, which promotes intracellular labile iron pool accumulation, and was alleviated by HO-1 knockdown and inhibition by tin protoporphyrin IX.	Iron	101-105	heme oxygenase 1	Mus musculus	59-63
33580994-0	2021	Modulating NF-kappaB, MAPK, and PI3K/AKT signaling by ergothioneine attenuates iron overload-induced hepatocellular injury in rats.	Iron	79-83	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
33580994-4	2021	The results showed that ergothioneine inhibited iron-evoked inflammation and apoptosis as demonstrated by a significant reduction in tumor necrosis factor-alpha and interleukin-6 levels and in caspase-3 activity.	Iron	48-52	tumor necrosis factor	Rattus norvegicus	133-160
33580994-4	2021	The results showed that ergothioneine inhibited iron-evoked inflammation and apoptosis as demonstrated by a significant reduction in tumor necrosis factor-alpha and interleukin-6 levels and in caspase-3 activity.	Iron	48-52	interleukin 6	Rattus norvegicus	165-178
33903292-3	2021	The diagnosis was made because the patient had an elevated transferrin concentration in the setting of a minimally elevated serum iron concentration and faint radio-opacities on abdominal plain film imaging.	Iron	130-134	transferrin	Homo sapiens	59-70
33453373-4	2021	OBJECTIVES: This is the first study which measured serum CLNK in TDT patients and examines the correlation between CLNK and iron overload biomarkers.	Iron	124-128	cytokine dependent hematopoietic cell linker	Homo sapiens	115-119
33453373-10	2021	The increased levels of CLNK were significantly associated with indicants of iron overload, namely increased ferritin levels.	Iron	77-81	cytokine dependent hematopoietic cell linker	Homo sapiens	24-28
33946721-6	2021	Except for down-regulation under nitrogen starvation, the CrCUL3 gene was induced by sulfur and iron starvation.	Iron	96-100	uncharacterized protein	Chlamydomonas reinhardtii	58-64
33987030-1	2021	Background: Hepcidin controls iron homeostasis by inducing the degradation of the iron efflux protein, ferroportin (FPN1), and subsequently reducing serum iron levels.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	116-120
33987030-1	2021	Background: Hepcidin controls iron homeostasis by inducing the degradation of the iron efflux protein, ferroportin (FPN1), and subsequently reducing serum iron levels.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	116-120
33987030-10	2021	Results: We found the inductive effects of LPS on liver IL-6 mRNA expression to be more pronounced under parenteral iron loading.	Iron	116-120	interleukin 6	Mus musculus	56-60
33987030-11	2021	Upon LPS administration, splenic erythroferrone (ERFE) mRNA levels were reduced only in iron-treated mice, whereas, liver bone morphogenetic protein 6 (BMP6) mRNA levels were decreased under both control and parenteral iron loading conditions.	Iron	88-92	erythroferrone	Mus musculus	49-53
33879618-1	2021	DDX11 encodes an iron-sulfur cluster DNA helicase required for development, mutated, and overexpressed in cancers.	Iron	17-21	DEAD/H-box helicase 11	Homo sapiens	0-5
33909969-4	2021	The plaques contain also metal ions of e.g. Cu, Fe, and Zn, and such ions are known to interact with Abeta peptides and modulate their aggregation and toxicity.	Iron	48-50	amyloid beta precursor protein	Homo sapiens	101-106
33925597-4	2021	Dietary iron is taken up by the divalent metal transporter 1 (DMT1) in enterocytes and transported to portal blood via ferroportin (FPN), where it is bound to transferrin and taken up by hepatocytes, macrophages and bone marrow cells via transferrin receptor 1 (TfR1).	Iron	8-12	transferrin	Homo sapiens	159-170
33895792-0	2021	RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.	Iron	17-21	ring finger protein 217	Mus musculus	0-6
33925631-6	2021	Using a combined bioinformatics tool kit, we demonstrated that the activation of dPerk leads to translational repression of mitochondrial proteins associated with glutathione and nucleotide metabolism, calcium signalling and iron-sulphur cluster biosynthesis.	Iron	225-229	pancreatic eIF-2alpha kinase	Drosophila melanogaster	81-86
28846259-4	2022	Iron also is found bound to proteins (hemoprotein) and in non-heme enzymes involved in oxidation-reduction reactions and the transfer of electrons (cytochromes and catalase).	Iron	0-4	catalase	Homo sapiens	164-172
33895792-8	2021	Finally, using two conditional knockout mouse lines, we found that knocking out Rnf217 in macrophages increases splenic iron export by stabilizing FPN, whereas knocking out Rnf217 in intestinal cells appears to increase iron absorption.	Iron	120-124	ring finger protein 217	Mus musculus	80-86
33895792-9	2021	These findings suggest that the Tet1-RNF217-FPN axis regulates iron homeostasis, revealing new therapeutic targets for FPN-related diseases.	Iron	63-67	ring finger protein 217	Mus musculus	37-43
33870790-8	2022	In univariable analysis, having >=2 iron rims (vs 0) was associated with increased CSF CHI3L1 levels (beta = 1.41; 95% confidence interval (CI) = 1.10-1.79; p < 0.01) and serum NfL levels (beta = 2.30; 95% CI = 1.47-3.60; p < 0.01).	Iron	36-40	BCL2 related protein A1	Homo sapiens	102-110
33729752-0	2021	FeNX(C)-Coated Microscale Zero-Valent Iron for Fast and Stable Trichloroethylene Dechlorination in both Acidic and Basic pH Conditions.	Iron	38-42	Fas activated serine/threonine kinase	Homo sapiens	47-51
33861975-9	2021	The improved performance in Nd1-xCoxFeO3 nanostructures were well justified to the successful incorporation of Co ions that sway the Nd-O, Co-O and Co-Fe-O bondings and boost the photon absorption and electronic conductivity to facilitate the observed performance.	Iron	36-38	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	28-31
33870790-8	2022	In univariable analysis, having >=2 iron rims (vs 0) was associated with increased CSF CHI3L1 levels (beta = 1.41; 95% confidence interval (CI) = 1.10-1.79; p < 0.01) and serum NfL levels (beta = 2.30; 95% CI = 1.47-3.60; p < 0.01).	Iron	36-40	ATPase H+ transporting V0 subunit a2	Homo sapiens	189-197
33870790-9	2022	In multivariable analysis, however, only CSF CHI3L1 levels remained significantly associated with the presence of iron rim lesions (beta = 1.45; 95% CI = 1.11-1.90; p < 0.01).	Iron	114-118	BCL2 related protein A1	Homo sapiens	132-140
33850216-0	2021	Association of common TMPRSS6 and TF gene variants with hepcidin and iron status in healthy rural Gambians.	Iron	69-73	transmembrane serine protease 6	Homo sapiens	22-29
33872860-0	2021	Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload.	Iron	0-4	insulin	Homo sapiens	24-31
33872860-10	2021	RESULTS: We show that features associated with T2DM in Leprdb/db mice, such as obesity, steatosis or insulin resistance reduce the degree of tissue iron overload in Fpnwt/C326S mice, suggesting an "iron resistance" phenotype.	Iron	148-152	insulin	Homo sapiens	101-108
33872860-10	2021	RESULTS: We show that features associated with T2DM in Leprdb/db mice, such as obesity, steatosis or insulin resistance reduce the degree of tissue iron overload in Fpnwt/C326S mice, suggesting an "iron resistance" phenotype.	Iron	198-202	insulin	Homo sapiens	101-108
33872860-12	2021	Increased hepatic iron levels induce oxidative stress and lipid peroxidation and aggravate insulin resistance, as indicated by diminished IRS1 phosphorylation and AKT activation.	Iron	18-22	insulin	Homo sapiens	91-98
33872860-12	2021	Increased hepatic iron levels induce oxidative stress and lipid peroxidation and aggravate insulin resistance, as indicated by diminished IRS1 phosphorylation and AKT activation.	Iron	18-22	thymoma viral proto-oncogene 1	Mus musculus	163-166
33855718-5	2021	Here we identified two Arabidopsis DnaJ proteins, DJA6 and DJA5, that can bind iron through their conserved cysteine residues and facilitate iron incorporation into Fe-S clusters by interactions with the SUF (sulfur utilization factor) apparatus through their J domain.	Iron	79-83	DNAJ heat shock family protein	Arabidopsis thaliana	50-54
33855718-5	2021	Here we identified two Arabidopsis DnaJ proteins, DJA6 and DJA5, that can bind iron through their conserved cysteine residues and facilitate iron incorporation into Fe-S clusters by interactions with the SUF (sulfur utilization factor) apparatus through their J domain.	Iron	79-83	Molecular chaperone Hsp40/DnaJ family protein	Arabidopsis thaliana	59-63
33855718-5	2021	Here we identified two Arabidopsis DnaJ proteins, DJA6 and DJA5, that can bind iron through their conserved cysteine residues and facilitate iron incorporation into Fe-S clusters by interactions with the SUF (sulfur utilization factor) apparatus through their J domain.	Iron	141-145	DNAJ heat shock family protein	Arabidopsis thaliana	50-54
33855718-5	2021	Here we identified two Arabidopsis DnaJ proteins, DJA6 and DJA5, that can bind iron through their conserved cysteine residues and facilitate iron incorporation into Fe-S clusters by interactions with the SUF (sulfur utilization factor) apparatus through their J domain.	Iron	141-145	Molecular chaperone Hsp40/DnaJ family protein	Arabidopsis thaliana	59-63
33855718-5	2021	Here we identified two Arabidopsis DnaJ proteins, DJA6 and DJA5, that can bind iron through their conserved cysteine residues and facilitate iron incorporation into Fe-S clusters by interactions with the SUF (sulfur utilization factor) apparatus through their J domain.	Iron	165-167	DNAJ heat shock family protein	Arabidopsis thaliana	50-54
33855718-5	2021	Here we identified two Arabidopsis DnaJ proteins, DJA6 and DJA5, that can bind iron through their conserved cysteine residues and facilitate iron incorporation into Fe-S clusters by interactions with the SUF (sulfur utilization factor) apparatus through their J domain.	Iron	165-167	Molecular chaperone Hsp40/DnaJ family protein	Arabidopsis thaliana	59-63
33852169-0	2021	In-cellulo Mossbauer and EPR studies bring new evidences to the long-standing debate on the iron-sulfur cluster binding in human anamorsin.	Iron	92-96	cytokine induced apoptosis inhibitor 1	Homo sapiens	129-138
33852169-1	2021	Human anamorsin is an iron-sulfur (Fe-S) cluster binding protein acting as an electron donor in the early steps of cytosolic iron-sulfur protein biogenesis.	Iron	35-39	cytokine induced apoptosis inhibitor 1	Homo sapiens	6-15
33852169-2	2021	Human anamorsin belongs to the eukaryotic CIAPIN1 protein family and contains two highly conserved cysteine-rich motifs each binding an Fe-S cluster.	Iron	136-138	cytokine induced apoptosis inhibitor 1	Homo sapiens	6-15
33852169-2	2021	Human anamorsin belongs to the eukaryotic CIAPIN1 protein family and contains two highly conserved cysteine-rich motifs each binding an Fe-S cluster.	Iron	136-138	cytokine induced apoptosis inhibitor 1	Homo sapiens	42-49
33852169-3	2021	In vitro works by various groups has provided rather controversial results for the type of Fe-S clusters bound to the CIAPIN1 proteins.	Iron	91-95	cytokine induced apoptosis inhibitor 1	Homo sapiens	118-125
33852169-4	2021	In order to solve this debate, we exploited an in cellulo approach combining Mossbauer and EPR spectroscopies to characterize the iron-sulfur cluster bound form of human anamorsin.	Iron	130-134	cytokine induced apoptosis inhibitor 1	Homo sapiens	170-179
33852740-7	2021	RESULTS: We found that high CRP is associated with a lack of response to iron supplementation after 1 month of treatment and that BMI z-score may moderate this association.	Iron	73-77	C-reactive protein	Homo sapiens	28-31
33852740-10	2021	CONCLUSIONS: Our finding suggesting that adiposity and CRP influence response to iron supplementation, furthers our understanding of the relationship between inflammation and anemia treatment in children and has both theoretical and public health implications.	Iron	81-85	C-reactive protein	Homo sapiens	55-58
33854135-6	2021	We did find evidence of an increase in IL-8 production by epithelial cells with increasing bioavailable iron (p = 0.01), however, this was not linked to the pyrite content of the coal (p = 0.75) and we did not see any evidence of a positive association in the other cell types.	Iron	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
33843443-3	2021	The precise cellular function of WDR45 is still largely unknown, but deletions or conventional variants in WDR45 can lead to macroautophagy/autophagy defects, malfunctioning mitochondria, endoplasmic reticulum stress and unbalanced iron homeostasis, suggesting that this protein functions in one or more pathways regulating directly or indirectly those processes.	Iron	232-236	WD repeat domain 45	Homo sapiens	107-112
33872860-16	2021	These findings imply that iron depletion strategies together with anti-diabetic drugs may ameliorate insulin resistance and diabetic late complications.	Iron	26-30	insulin	Homo sapiens	101-108
33863963-0	2021	Low serum iron is associated with anemia in CKD stage 1-4 patients with normal transferrin saturations.	Iron	10-14	transferrin	Homo sapiens	79-90
33863963-1	2021	Low transferrin saturation (TSAT), calculated by serum iron divided by total iron-binding capacity (TIBC), indicates iron deficiency.	Iron	55-59	transferrin	Homo sapiens	4-15
33863963-1	2021	Low transferrin saturation (TSAT), calculated by serum iron divided by total iron-binding capacity (TIBC), indicates iron deficiency.	Iron	77-81	transferrin	Homo sapiens	4-15
33610598-7	2021	The results indicated that heparin-iron has significantly reduced anticoagulant activity in vitro and in vivo, strongly decreases hepcidin mRNA and IL-6 induced high level of secreted hepcidin in HepG2 cell.	Iron	35-39	interleukin 6	Homo sapiens	148-152
33610598-8	2021	Heparin-iron was also found to cause a reduction on hepcidin expression through BMP/SMAD and JAK/STAT3 pathways in LPS induced acute inflammation model in mice.	Iron	8-12	signal transducer and activator of transcription 3	Mus musculus	97-102
33845758-3	2021	Herein, a truncated synthetic analog containing the gamma-core motif of Amaranthus tricolor DEF2 (Atr-DEF2) reveals Gram-negative antibacterial activity and its mechanism of action is probed via proteomics, outer membrane permeability studies, and iron reduction/chelation assays.	Iron	248-252	ATR serine/threonine kinase	Homo sapiens	98-101
33850216-0	2021	Association of common TMPRSS6 and TF gene variants with hepcidin and iron status in healthy rural Gambians.	Iron	69-73	transferrin	Homo sapiens	34-36
33850216-1	2021	Genome-wide association studies in Europeans and Asians have identified numerous variants in the transmembrane protease serine 6 (TMPRSS6) and transferrin (TF) genes that are associated with changes in iron status.	Iron	202-206	transmembrane serine protease 6	Homo sapiens	97-128
33850216-1	2021	Genome-wide association studies in Europeans and Asians have identified numerous variants in the transmembrane protease serine 6 (TMPRSS6) and transferrin (TF) genes that are associated with changes in iron status.	Iron	202-206	transmembrane serine protease 6	Homo sapiens	130-137
33850216-1	2021	Genome-wide association studies in Europeans and Asians have identified numerous variants in the transmembrane protease serine 6 (TMPRSS6) and transferrin (TF) genes that are associated with changes in iron status.	Iron	202-206	transferrin	Homo sapiens	143-154
33850216-1	2021	Genome-wide association studies in Europeans and Asians have identified numerous variants in the transmembrane protease serine 6 (TMPRSS6) and transferrin (TF) genes that are associated with changes in iron status.	Iron	202-206	transferrin	Homo sapiens	156-158
33850216-2	2021	We sought to investigate the effects of common TMPRSS6 and TF gene SNPs on iron status indicators in a cohort of healthy Africans from rural Gambia.	Iron	75-79	transmembrane serine protease 6	Homo sapiens	47-54
33850216-2	2021	We sought to investigate the effects of common TMPRSS6 and TF gene SNPs on iron status indicators in a cohort of healthy Africans from rural Gambia.	Iron	75-79	transferrin	Homo sapiens	59-61
33850216-8	2021	TF rs3811647 AA carriers had 21% higher transferrin (F ratio 16.0, P < 0.0001), 24% higher unsaturated iron-binding capacity (F ratio 12.8, P < 0.0001) and 25% lower transferrin saturation (F ratio 4.3, P < 0.0001) compared to GG carriers.	Iron	103-107	transferrin	Homo sapiens	0-2
33850216-9	2021	TF rs3811647 was strongly associated with transferrin, unsaturated iron-binding capacity (UIBC) and transferrin saturation (TSAT) with a single allele effect of 8-12%.	Iron	67-71	transferrin	Homo sapiens	0-2
33850216-11	2021	We identified meaningful associations between TMPRSS6 rs2235321 and hepcidin and replicated the previous findings on the effects of TF rs3811647 on transferrin and iron binding capacity.	Iron	164-168	transmembrane serine protease 6	Homo sapiens	46-53
33850216-11	2021	We identified meaningful associations between TMPRSS6 rs2235321 and hepcidin and replicated the previous findings on the effects of TF rs3811647 on transferrin and iron binding capacity.	Iron	164-168	transferrin	Homo sapiens	132-134
33850218-0	2021	An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia.	Iron	79-83	fibroblast growth factor 21	Homo sapiens	23-50
33920401-3	2021	Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits.	Iron	45-49	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
33920401-3	2021	Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
33538226-3	2021	Recently, we showed that MYB28 and MYB29 transcription factors play a role in ammonium tolerance, since its double mutant (myb28myb29) is highly hypersensitive toward ammonium nutrition in relation to altered Fe homeostasis.	Iron	209-211	myb domain protein 29	Arabidopsis thaliana	35-40
33912577-4	2021	Iron supply to the kidney is dependent on systemic iron availability, which is regulated by the hepcidin-ferroportin axis.	Iron	0-4	hepcidin	Equus caballus	96-104
33912577-4	2021	Iron supply to the kidney is dependent on systemic iron availability, which is regulated by the hepcidin-ferroportin axis.	Iron	51-55	hepcidin	Equus caballus	96-104
33917391-10	2021	Furthermore, we related TFR1 expression with the clinical profile of patients and showed that greater iron demand in sera-treated cells was associated with higher inflammation score (interleukin 6 (IL-6), C-reactive protein (CRP)) and advanced neurohormonal activation (NT-proBNP) in patients.	Iron	102-106	interleukin 6	Homo sapiens	183-196
33917391-10	2021	Furthermore, we related TFR1 expression with the clinical profile of patients and showed that greater iron demand in sera-treated cells was associated with higher inflammation score (interleukin 6 (IL-6), C-reactive protein (CRP)) and advanced neurohormonal activation (NT-proBNP) in patients.	Iron	102-106	interleukin 6	Homo sapiens	198-202
33917391-10	2021	Furthermore, we related TFR1 expression with the clinical profile of patients and showed that greater iron demand in sera-treated cells was associated with higher inflammation score (interleukin 6 (IL-6), C-reactive protein (CRP)) and advanced neurohormonal activation (NT-proBNP) in patients.	Iron	102-106	C-reactive protein	Homo sapiens	205-223
33917391-10	2021	Furthermore, we related TFR1 expression with the clinical profile of patients and showed that greater iron demand in sera-treated cells was associated with higher inflammation score (interleukin 6 (IL-6), C-reactive protein (CRP)) and advanced neurohormonal activation (NT-proBNP) in patients.	Iron	102-106	C-reactive protein	Homo sapiens	225-228
33916579-1	2021	Mitochondrial production of 2-hydroxyglutarate (2HG) can be catalyzed by wild-type isocitrate dehydrogenase 2 (IDH2) and alcohol dehydrogenase, iron-containing 1 (ADHFE1).	Iron	144-148	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	111-115
31902301-2	2021	Iron depletion was defined as serum iron &lt;10 mmol/L and decreased transferrin saturation irrespective of the coexistence of anaemia.	Iron	0-4	transferrin	Homo sapiens	69-80
33867736-7	2021	Following iron therapy, hematological parameters was improved together with a significant increase in GPx (P = 0.04), SOD (p = 0.002), TAC (P = 0.001) and non-significant reduction in DNA damage in IDA group.	Iron	10-14	superoxide dismutase 1	Homo sapiens	118-121
33815881-5	2021	Age-related macular degeneration (AMD) is characterized by retinal iron accumulation and lipid peroxidation.	Iron	67-71	renin binding protein	Homo sapiens	0-3
33539815-5	2021	Our results assessed the inhibitory effect of EP on IFN-alpha signaling, which contributes to the downregulation of ISGs produced by monocytes and sheds light on the underlying mechanisms using iron chelation to treat patients with hepatitis-related immunological thrombocytopenia.	Iron	194-198	interferon alpha 1	Homo sapiens	52-61
33097833-4	2021	Mechanistically, ferroptosis inducers (erastin, sorafenib, and sulfasalazine) activated AMPK/SREBP1 signaling pathway through iron-dependent ferritinophagy, which in turn inhibited BCAT2 transcription.	Iron	126-130	branched chain amino acid transaminase 2	Homo sapiens	181-186
32794021-0	2021	Homocysteine-induced decrease in HUVEC cells" resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism.	Iron	117-121	AKT serine/threonine kinase 1	Homo sapiens	92-95
33815881-0	2021	Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration.	Iron	0-4	renin binding protein	Homo sapiens	92-95
33987429-5	2021	The majority of genetically predisposed individuals show at least some evidence of iron loading (increased transferrin saturation and serum ferritin), but a minority show clinical symptoms and severe consequences are rare.	Iron	83-87	transferrin	Homo sapiens	107-118
32237057-2	2021	In mammals, the well-characterized transferrins bind iron and are involved in iron transport or immunity, whereas other members of the transferrin family do not have a role in iron homeostasis.	Iron	53-57	transferrin	Homo sapiens	35-46
33274450-0	2021	Histone H3 lysine4 trimethylation-regulated GRF11 expression is essential for the iron deficiency response in Arabidopsis thaliana.	Iron	82-86	general regulatory factor 11	Arabidopsis thaliana	44-49
32237057-2	2021	In mammals, the well-characterized transferrins bind iron and are involved in iron transport or immunity, whereas other members of the transferrin family do not have a role in iron homeostasis.	Iron	78-82	transferrin	Homo sapiens	35-46
32237057-2	2021	In mammals, the well-characterized transferrins bind iron and are involved in iron transport or immunity, whereas other members of the transferrin family do not have a role in iron homeostasis.	Iron	78-82	transferrin	Homo sapiens	35-46
33393188-4	2021	To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction.	Iron	162-166	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	119-123
33274450-4	2021	By using a forward genetics approach, we identified a crucial allele for Fe deficiency response, NON-RESPONSE TO Fe-DEFICIENCY2 (NRF2) previously described as EARLY FLOWERING8 (ELF8) associated with an activation mark on histone modification, histone H3 lysine4 trimethylation.	Iron	73-75	binding protein	Arabidopsis thaliana	159-175
33274450-4	2021	By using a forward genetics approach, we identified a crucial allele for Fe deficiency response, NON-RESPONSE TO Fe-DEFICIENCY2 (NRF2) previously described as EARLY FLOWERING8 (ELF8) associated with an activation mark on histone modification, histone H3 lysine4 trimethylation.	Iron	73-75	binding protein	Arabidopsis thaliana	177-181
33274450-5	2021	In the nrf2-1 mutant, a point mutation at ELF8T404I , exhibits impaired expression of GENERAL REGULATORY FACTOR11 (GRF11) and downstream genes in the Fe uptake pathway.	Iron	150-152	general regulatory factor 11	Arabidopsis thaliana	86-113
33274450-5	2021	In the nrf2-1 mutant, a point mutation at ELF8T404I , exhibits impaired expression of GENERAL REGULATORY FACTOR11 (GRF11) and downstream genes in the Fe uptake pathway.	Iron	150-152	general regulatory factor 11	Arabidopsis thaliana	115-120
33493903-1	2021	Association of both iron/hepcidin and apolipoprotein E (ApoE) with development of Alzheimer disease (AD) and atherosclerosis led us to hypothesize that ApoE might be required for body iron homeostasis.	Iron	20-24	apolipoprotein E	Mus musculus	152-156
33493903-1	2021	Association of both iron/hepcidin and apolipoprotein E (ApoE) with development of Alzheimer disease (AD) and atherosclerosis led us to hypothesize that ApoE might be required for body iron homeostasis.	Iron	184-188	apolipoprotein E	Mus musculus	152-156
33440293-4	2021	Hypochlorite-modified fibrinogen is stable at 37  C as assessed by precipitation assays, and has reduced susceptibility to iron-induced (hydroxyl-mediated) precipitation compared to native fibrinogen.	Iron	123-127	fibrinogen beta chain	Homo sapiens	22-32
33493903-2	2021	Here, we demonstrated that ApoE knock-out (KO) induced a progressive accumulation of iron with age in the liver and spleen of mice.	Iron	85-89	apolipoprotein E	Mus musculus	27-31
33493903-3	2021	Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1.	Iron	52-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	215-258
33795736-5	2021	We find that micromolar concentrations of iron(III) and copper(II) are more important sinks for ascorbic acid (both AH2 and AH-) than reactive oxygen species.	Iron	42-46	zinc finger RANBP2-type containing 3	Homo sapiens	116-119
33795736-6	2021	The iron and copper reactions are catalytic rather than redox reactions, and have unit stoichiometries: Fe(III)/Cu(II) + AH2/AH-  + O2   Fe(III)/Cu(II) + H2O2 + products.	Iron	4-8	zinc finger RANBP2-type containing 3	Homo sapiens	121-124
33493903-3	2021	Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1.	Iron	52-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	260-264
33493903-3	2021	Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1.	Iron	52-56	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	295-308
33493903-4	2021	Furthermore, replenishment of ApoE could partially reverse the iron-related phenotype in ApoE KO mice.	Iron	63-67	apolipoprotein E	Mus musculus	30-34
33493903-4	2021	Furthermore, replenishment of ApoE could partially reverse the iron-related phenotype in ApoE KO mice.	Iron	63-67	apolipoprotein E	Mus musculus	89-93
33493903-5	2021	The findings imply that ApoE may be essential for body iron homeostasis and also suggest that clinical late-onset diseases with unexplained iron abnormality may partly be related to deficiency or reduced expression of ApoE.	Iron	55-59	apolipoprotein E	Mus musculus	24-28
33493903-5	2021	The findings imply that ApoE may be essential for body iron homeostasis and also suggest that clinical late-onset diseases with unexplained iron abnormality may partly be related to deficiency or reduced expression of ApoE.	Iron	140-144	apolipoprotein E	Mus musculus	24-28
33493903-5	2021	The findings imply that ApoE may be essential for body iron homeostasis and also suggest that clinical late-onset diseases with unexplained iron abnormality may partly be related to deficiency or reduced expression of ApoE.	Iron	140-144	apolipoprotein E	Mus musculus	218-222
33785447-7	2021	In this review, we will summarize the roles of p53 in the regulation of glucose, lipid, amino acid, nucleotide, iron metabolism, and ROS production.	Iron	112-116	tumor protein p53	Homo sapiens	47-50
33625078-4	2022	Because of their mutual link, bioavailable iron and endogenous erythropoietin (EPO) are indispensable for effective erythropoiesis.	Iron	43-47	erythropoietin	Homo sapiens	79-82
33625078-7	2022	A negative trend was also noted on the impact of iron concentration and transferrin saturation on EPO production.	Iron	49-53	erythropoietin	Homo sapiens	98-101
33625078-8	2022	In conclusion, this preliminary study demonstrates an impaired impact of endogenous EPO on erythropoiesis in the presence of increased iron content in carriers of p.(His63Asp) (heterozygotes) variant of the HFE gene in developmental age.	Iron	135-139	erythropoietin	Homo sapiens	84-87
28613462-0	2022	Hallervorden Spatz Disease (Pantothenate Kinase-Associated Neurodegeneration, PKAN) Hallervorden-Spatz disease now more commonly known as Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain nuclei and characterized by progressive extrapyramidal dysfunction and dementia.	Iron	267-271	pantothenate kinase 2	Homo sapiens	28-76
28613462-0	2022	Hallervorden Spatz Disease (Pantothenate Kinase-Associated Neurodegeneration, PKAN) Hallervorden-Spatz disease now more commonly known as Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain nuclei and characterized by progressive extrapyramidal dysfunction and dementia.	Iron	267-271	pantothenate kinase 2	Homo sapiens	78-82
28613462-0	2022	Hallervorden Spatz Disease (Pantothenate Kinase-Associated Neurodegeneration, PKAN) Hallervorden-Spatz disease now more commonly known as Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain nuclei and characterized by progressive extrapyramidal dysfunction and dementia.	Iron	267-271	pantothenate kinase 2	Homo sapiens	138-186
28613462-0	2022	Hallervorden Spatz Disease (Pantothenate Kinase-Associated Neurodegeneration, PKAN) Hallervorden-Spatz disease now more commonly known as Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain nuclei and characterized by progressive extrapyramidal dysfunction and dementia.	Iron	267-271	pantothenate kinase 2	Homo sapiens	188-192
33789892-4	2021	In the Iron Age, in general, Steppe-related and northeastern Asian admixture intensified, with North and East Xinjiang populations showing more affinity with northeastern Asians and South Xinjiang populations showing more affinity with Central Asians.	Iron	7-11	renin binding protein	Homo sapiens	12-15
33948532-4	2021	Objectives: We hypothesized that the addition of iron to iodized salt can adversely affect iodine status in women of reproductive age (WRA).	Iron	49-53	renin binding protein	Homo sapiens	130-133
33898949-0	2021	Roquin is a major mediator of iron-regulated changes to transferrin receptor-1 mRNA stability.	Iron	30-34	ring finger and CCCH-type domains 1	Homo sapiens	0-6
33898949-4	2021	Here, we show with gene knockouts and siRNA knockdowns that two Roquin paralogs are major mediators of iron-regulated changes to the steady-state TfR1 mRNA level within four different cell types (HAP1, HUVEC, L-M, and MEF).	Iron	103-107	ring finger and CCCH-type domains 1	Homo sapiens	64-70
33898949-5	2021	Roquin is demonstrated to destabilize the TfR1 mRNA, and its activity is fully dependent on three hairpin loops within the TfR1 mRNA 3"-UTR that are essential for iron-regulated instability.	Iron	163-167	ring finger and CCCH-type domains 1	Homo sapiens	0-6
33749990-7	2021	The changes in duodenal calcium and phosphate absorption in the iron deficient animals were associated with increased claudin 2 and 3 mRNA and protein levels, while levels of parathyroid hormone, fibroblast growth factor-23 and 1,25-dihydroxy vitamin D3 were unchanged.	Iron	64-68	claudin 2	Rattus norvegicus	118-133
33462622-3	2021	OBJECTIVES: (i) To determine the effect of iron depletion on the insulin sensitivity and frequency of abnormal glucose tolerance in patients with functional hyperandrogenism submitted to standard therapy with combined oral contraceptives (COC).	Iron	43-47	insulin	Homo sapiens	65-72
33790545-10	2021	Logistic regression showed that patients with high serum iron levels (>=7.8mumol/L) showed a lower risk of SAP (OR=0.43, 95% CI, 0.27-0.69, P < 0.001).	Iron	57-61	SH2 domain containing 1A	Homo sapiens	107-110
33790545-3	2021	This study aimed to explore the relationship between serum iron levels and stroke-associated pneumonia (SAP).	Iron	59-63	SH2 domain containing 1A	Homo sapiens	104-107
33554718-0	2021	Non-transferrin-bound iron in the spotlight: novel mechanistic insights into the vasculo-toxic and atherosclerotic effect of iron.	Iron	22-26	transferrin	Homo sapiens	4-15
33554718-0	2021	Non-transferrin-bound iron in the spotlight: novel mechanistic insights into the vasculo-toxic and atherosclerotic effect of iron.	Iron	125-129	transferrin	Homo sapiens	4-15
33790545-6	2021	The predictive value of serum iron to SAP was evaluated by receiver operating characteristic curve (ROC) and binary Logistic regression models.	Iron	30-34	SH2 domain containing 1A	Homo sapiens	38-41
33790545-7	2021	A restricted cubic spline (RCS) was used to furtherly clarify the relationship between serum iron and the risk of SAP.	Iron	93-97	SH2 domain containing 1A	Homo sapiens	114-117
33790545-9	2021	Serum iron levels in the SAP group were significantly lower than those in the Non-SAP group (9.77+-5.61 vs 14.01+-6.80, P < 0.001).	Iron	6-10	SH2 domain containing 1A	Homo sapiens	25-28
33790545-11	2021	Besides, the RCS model showed that there was an L-shaped relationship between the serum iron and risk of SAP (P for non-linearity: 0.014).	Iron	88-92	SH2 domain containing 1A	Homo sapiens	105-108
33790545-12	2021	Conclusion: Low serum iron level was a risk factor for SAP, and there was an L-shaped relationship between them.	Iron	22-26	SH2 domain containing 1A	Homo sapiens	55-58
33790545-13	2021	Stroke patients with low serum iron levels should be alert to the risk of SAP.	Iron	31-35	SH2 domain containing 1A	Homo sapiens	74-77
33737539-7	2021	At 14q32, miR-432-5p and miR-127-3p were ~ 100-fold downregulated whereas miR-138-5p was 16-fold downregulated at 3p21 in chronic iron-exposed FTSECs.	Iron	130-134	microRNA 1273a	Homo sapiens	25-35
33751340-13	2021	Significant strong correlation showed for the value of iron in both ferric reducing ability of plasma (FRAP) and Oxygen Radical Absorbance Capacity (ORAC) indices (p<0.0001).	Iron	55-59	mechanistic target of rapamycin kinase	Homo sapiens	103-107
33688880-2	2021	Elevated levels of metals, specifically copper, zinc, iron, and aluminum, accumulate in senile Abeta; plaque deposits, disrupting normal brain homeostasis and cognitive functions.	Iron	54-58	amyloid beta precursor protein	Homo sapiens	95-100
33729329-7	2021	Cd, Cr and Fe were correlated positively with CAT and negatively with TBARS and GR.	Iron	11-13	catalase	Homo sapiens	46-49
33937615-3	2021	The subcellular locations of transferrin receptor and ferroportin 1 in iron-transporting cells in the mouse placenta have not been directly assessed.	Iron	71-75	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	54-67
33326120-1	2021	A detailed reaction mechanism of acetylene cyclotrimerization catalyzed by V(i PrNPMe2 )3 Fe-PMe3 (denote as CAT), a heterobimetallic complex featuring V-Fe triple bond, was computationally investigated using density functional theory.	Iron	90-92	catalase	Homo sapiens	109-112
32506180-7	2021	Our results suggest the protective effect of caffeic acid against iron-mediated cardiotoxicity as indicated by its ability to suppress oxidative imbalance and ACE activity, while concomitantly modulating nucleotide hydrolysis and metabolic switch.	Iron	66-70	angiotensin I converting enzyme	Rattus norvegicus	159-162
33693920-10	2021	RESULTS: Genetically predicted iron status was associated with altered risk of SLE, with ORs of 0.79 (95% CI: 0.66, 0.94), 0.54 (95% CI: 0.34, 0.85), 0.82 (95% CI: 0.71, 0.94), and 1.36 (95% CI: 1.06, 1.76) per 1-SD increase in iron, log-transformed ferritin, transferrin saturation, and transferrin using the IVW method, respectively.	Iron	31-35	transferrin	Homo sapiens	260-271
33693920-10	2021	RESULTS: Genetically predicted iron status was associated with altered risk of SLE, with ORs of 0.79 (95% CI: 0.66, 0.94), 0.54 (95% CI: 0.34, 0.85), 0.82 (95% CI: 0.71, 0.94), and 1.36 (95% CI: 1.06, 1.76) per 1-SD increase in iron, log-transformed ferritin, transferrin saturation, and transferrin using the IVW method, respectively.	Iron	31-35	transferrin	Homo sapiens	288-299
33683742-8	2021	UL iron significantly reduced glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and total anti-oxidation capacity (T-AOC) in the liver (p < 0.05).	Iron	3-7	superoxide dismutase 1	Homo sapiens	63-83
33683742-8	2021	UL iron significantly reduced glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and total anti-oxidation capacity (T-AOC) in the liver (p < 0.05).	Iron	3-7	superoxide dismutase 1	Homo sapiens	85-88
33686957-5	2021	The circRHOT1 knockdown notably increased the levels of reactive oxygen species (ROS), iron, and Fe2+ in breast cancer cells.	Iron	87-91	ras homolog family member T1	Homo sapiens	4-13
33661166-1	2021	This study was performed to investigate the gene polymorphisms of the myeloperoxidase (MPO) enzyme and to determine whether MPO gene polymorphisms influence the response to iron therapy in pediatric patients with iron deficiency anemia (IDA).	Iron	173-177	myeloperoxidase	Homo sapiens	124-127
33661166-8	2021	The frequency of AA, GG, and AG alleles of the MPO gene was potentially associated with changes in iron metabolism and the AG allele led to variations in various hemogram parameters.	Iron	99-103	myeloperoxidase	Homo sapiens	47-50
32468223-4	2021	Iron overload upregulated the pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, TNF-alpha), while downregulated the anti-inflammatory cytokines (IL-4, IL-10) and sIgA.	Iron	0-4	interleukin 6	Mus musculus	74-78
32468223-4	2021	Iron overload upregulated the pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, TNF-alpha), while downregulated the anti-inflammatory cytokines (IL-4, IL-10) and sIgA.	Iron	0-4	tumor necrosis factor	Mus musculus	80-89
32468223-4	2021	Iron overload upregulated the pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, TNF-alpha), while downregulated the anti-inflammatory cytokines (IL-4, IL-10) and sIgA.	Iron	0-4	interleukin 10	Mus musculus	151-156
32468223-5	2021	Moreover, iron overload increased serum D-lactate (D-LA) levels and decreased tight junction proteins (claudin-1, occludin, and ZO-1), MUC-2, and TFF3.	Iron	10-14	occludin	Mus musculus	114-122
32468223-5	2021	Moreover, iron overload increased serum D-lactate (D-LA) levels and decreased tight junction proteins (claudin-1, occludin, and ZO-1), MUC-2, and TFF3.	Iron	10-14	tight junction protein 1	Mus musculus	128-132
32479616-2	2021	In addition to absence of oxygen, sequestration of iron also stimulates HIF-1alpha.	Iron	51-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-82
33710528-7	2021	A novel form of iron deficiency was identified in Case 1, as biochemical testing at each hospital submission due to MS symptoms showed low serum iron, ferritin and transferrin saturation, while hematological status and erythrocyte sedimentation rate measurement of systemic inflammation remained normal.	Iron	16-20	transferrin	Homo sapiens	164-175
33683742-8	2021	UL iron significantly reduced glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and total anti-oxidation capacity (T-AOC) in the liver (p < 0.05).	Iron	3-7	catalase	Homo sapiens	101-104
33683742-9	2021	Nuclear factor erythroid 2-related factor 2 (Nrf2) activated subunits of glutamate cysteine ligase (Gclc) and glutathione S-transferase A1 (Gsta1) upregulation in the UL iron group liver, thereby increasing resistance to oxidative stress.	Iron	170-174	NFE2 like bZIP transcription factor 2	Homo sapiens	0-43
33683742-9	2021	Nuclear factor erythroid 2-related factor 2 (Nrf2) activated subunits of glutamate cysteine ligase (Gclc) and glutathione S-transferase A1 (Gsta1) upregulation in the UL iron group liver, thereby increasing resistance to oxidative stress.	Iron	170-174	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
33683742-10	2021	In conclusion, UL iron supplementation altered iron metabolism, generated free radicals, reduced antioxidant enzyme activity and activated Nrf2 signalling pathway in the weaned piglet liver.	Iron	18-22	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
32468223-5	2021	Moreover, iron overload increased serum D-lactate (D-LA) levels and decreased tight junction proteins (claudin-1, occludin, and ZO-1), MUC-2, and TFF3.	Iron	10-14	trefoil factor 3, intestinal	Mus musculus	146-150
32468223-6	2021	In addition, iron overload upregulated the content of MDA and protein carbonyl, while downregulated the activity and content of T-AOC, GSH-PX, SOD, CAT, and GSH.	Iron	13-17	catalase	Mus musculus	148-151
32506180-0	2021	Caffeic Acid Protects against Iron-Induced Cardiotoxicity by Suppressing Angiotensin-Converting Enzyme Activity and Modulating Lipid Spectrum, Gluconeogenesis and Nucleotide Hydrolyzing Enzyme Activities.	Iron	30-34	angiotensin I converting enzyme	Rattus norvegicus	73-102
33181752-2	2021	We present a case of a woman with ER-positive metastatic breast cancer and high [18F]-FES uptake in the dural region on PET imaging, without associated clinical symptoms.	Iron	86-89	estrogen receptor 1	Homo sapiens	34-36
33203734-4	2021	The lipogenesis regulator SREBF2 directly induces transcription of the iron carrier Transferrin (TF), reducing intracellular iron pools, reactive oxygen species (ROS) and lipid peroxidation, thereby conferring resistance to inducers of ferroptosis.	Iron	71-75	sterol regulatory element binding transcription factor 2	Homo sapiens	26-32
33203734-4	2021	The lipogenesis regulator SREBF2 directly induces transcription of the iron carrier Transferrin (TF), reducing intracellular iron pools, reactive oxygen species (ROS) and lipid peroxidation, thereby conferring resistance to inducers of ferroptosis.	Iron	71-75	transferrin	Homo sapiens	84-95
33203734-4	2021	The lipogenesis regulator SREBF2 directly induces transcription of the iron carrier Transferrin (TF), reducing intracellular iron pools, reactive oxygen species (ROS) and lipid peroxidation, thereby conferring resistance to inducers of ferroptosis.	Iron	125-129	sterol regulatory element binding transcription factor 2	Homo sapiens	26-32
33203734-4	2021	The lipogenesis regulator SREBF2 directly induces transcription of the iron carrier Transferrin (TF), reducing intracellular iron pools, reactive oxygen species (ROS) and lipid peroxidation, thereby conferring resistance to inducers of ferroptosis.	Iron	125-129	transferrin	Homo sapiens	84-95
33203734-7	2021	Thus, SREBF2-driven iron homeostatic pathways contribute to cancer progression, drug resistance and metastasis.	Iron	20-24	sterol regulatory element binding transcription factor 2	Homo sapiens	6-12
33497840-5	2021	T. gamsii up-regulates the expression of a ferric reductase involved in iron acquisition, while F. graminearum up-regulates the expression of genes coding for transmembrane transporters and killer toxins.	Iron	72-76	reductase	Trichoderma gamsii	50-59
33488803-3	2021	As a downstream target of Nrf2, heme oxygenase (HO) degrades heme to free iron, biliverdin and carbon monoxide (CO), which protects against oxidative stress.	Iron	74-78	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-30
33408127-8	2021	HO1 knockdown by shRNA or treatment of iron chelator rescued the aberrant gluconeogenesis in L-DKO mice.	Iron	39-43	heme oxygenase 1	Mus musculus	0-3
33408127-10	2021	Thus, our results demonstrate the role of HO1 in regulating hepatic iron status and Foxo1 to control gluconeogenesis and blood glucose.	Iron	68-72	heme oxygenase 1	Mus musculus	42-45
33486087-0	2021	Effects of Albumin, Transferrin and Humic-Like Substances on Iron-Mediated OH Radical Formation in Human Lung Fluids.	Iron	61-65	albumin	Homo sapiens	11-18
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	Iron	193-197	albumin	Homo sapiens	35-42
32438524-3	2021	Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells.	Iron	90-94	poly(rC) binding protein 1	Homo sapiens	0-25
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	Iron	193-197	tumor associated calcium signal transducer 2	Homo sapiens	108-115
33486087-0	2021	Effects of Albumin, Transferrin and Humic-Like Substances on Iron-Mediated OH Radical Formation in Human Lung Fluids.	Iron	61-65	transferrin	Homo sapiens	20-31
33188300-2	2021	4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by HPDL, is an orphan paralogue of 4-hydroxyphenylpyruvate dioxygenase (HPD), an iron-dependent dioxygenase involved in tyrosine catabolism.	Iron	146-150	4-hydroxyphenylpyruvate dioxygenase like	Homo sapiens	0-48
33188300-2	2021	4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by HPDL, is an orphan paralogue of 4-hydroxyphenylpyruvate dioxygenase (HPD), an iron-dependent dioxygenase involved in tyrosine catabolism.	Iron	146-150	4-hydroxyphenylpyruvate dioxygenase like	Homo sapiens	50-54
33188300-2	2021	4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by HPDL, is an orphan paralogue of 4-hydroxyphenylpyruvate dioxygenase (HPD), an iron-dependent dioxygenase involved in tyrosine catabolism.	Iron	146-150	4-hydroxyphenylpyruvate dioxygenase like	Homo sapiens	68-72
33188300-2	2021	4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by HPDL, is an orphan paralogue of 4-hydroxyphenylpyruvate dioxygenase (HPD), an iron-dependent dioxygenase involved in tyrosine catabolism.	Iron	146-150	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	0-35
32438524-3	2021	Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells.	Iron	90-94	poly(rC) binding protein 1	Homo sapiens	27-32
32438524-3	2021	Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells.	Iron	131-135	poly(rC) binding protein 1	Homo sapiens	0-25
32438524-3	2021	Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells.	Iron	131-135	poly(rC) binding protein 1	Homo sapiens	27-32
32438524-4	2021	While PCBP1 distributes iron in cells, its role in managing iron in mammalian tissues remains unexplored.	Iron	24-28	poly(rC) binding protein 1	Homo sapiens	6-11
32438524-6	2021	Mice lacking PCBP1 in hepatocytes exhibited defects in liver iron homeostasis with low levels of liver iron, reduced activity of iron enzymes, and misregulation of the cell-autonomous iron regulatory system.	Iron	61-65	poly(rC) binding protein 1	Mus musculus	13-18
32438524-6	2021	Mice lacking PCBP1 in hepatocytes exhibited defects in liver iron homeostasis with low levels of liver iron, reduced activity of iron enzymes, and misregulation of the cell-autonomous iron regulatory system.	Iron	103-107	poly(rC) binding protein 1	Mus musculus	13-18
32438524-6	2021	Mice lacking PCBP1 in hepatocytes exhibited defects in liver iron homeostasis with low levels of liver iron, reduced activity of iron enzymes, and misregulation of the cell-autonomous iron regulatory system.	Iron	103-107	poly(rC) binding protein 1	Mus musculus	13-18
32438524-9	2021	Although PCBP1-deleted livers were iron-deficient, dietary iron supplementation did not prevent steatosis; instead, dietary iron restriction and antioxidant therapy with vitamin E prevented liver disease.	Iron	35-39	poly(rC) binding protein 1	Mus musculus	9-14
32438524-10	2021	PCBP1-deleted hepatocytes exhibited increased labile iron and production of reactive oxygen species, were hypersensitive to iron and prooxidants, and accumulated oxidatively-damaged lipids due to the reactivity of unchaperoned iron.	Iron	53-57	poly(rC) binding protein 1	Mus musculus	0-5
32438524-10	2021	PCBP1-deleted hepatocytes exhibited increased labile iron and production of reactive oxygen species, were hypersensitive to iron and prooxidants, and accumulated oxidatively-damaged lipids due to the reactivity of unchaperoned iron.	Iron	124-128	poly(rC) binding protein 1	Mus musculus	0-5
33176226-0	2021	Co-occurrence of malignant neoplasm and Hyperostosis Frontalis Interna in an Iron Age individual from Munsingen-Rain (Switzerland): A multi-diagnostic study.	Iron	77-81	renin binding protein	Homo sapiens	82-85
32438524-10	2021	PCBP1-deleted hepatocytes exhibited increased labile iron and production of reactive oxygen species, were hypersensitive to iron and prooxidants, and accumulated oxidatively-damaged lipids due to the reactivity of unchaperoned iron.	Iron	124-128	poly(rC) binding protein 1	Mus musculus	0-5
32438524-11	2021	CONCLUSIONS: Unchaperoned iron in PCBP1-deleted mouse hepatocytes leads to production of reactive oxygen species, resulting in lipid peroxidation and steatosis in the absence of iron overload.	Iron	26-30	poly(rC) binding protein 1	Mus musculus	34-39
32438524-12	2021	The iron chaperone activity of PCBP1 is therefore critical for limiting the toxicity of cytosolic iron and may be a key factor in preventing the lipid peroxidation that triggers the ferroptotic cell death pathway.	Iron	4-8	poly(rC) binding protein 1	Mus musculus	31-36
32438524-12	2021	The iron chaperone activity of PCBP1 is therefore critical for limiting the toxicity of cytosolic iron and may be a key factor in preventing the lipid peroxidation that triggers the ferroptotic cell death pathway.	Iron	98-102	poly(rC) binding protein 1	Mus musculus	31-36
32446932-1	2021	OBJECTIVE/BACKGROUND: Mutations in transmembrane protease serine 6 (TMPRSS6) gene induce high hepcidin level, which causes iron-refractory iron deficiency anemia (IRIDA) by preventing duodenal iron absorption.	Iron	123-127	transmembrane serine protease 6	Homo sapiens	35-66
32446932-1	2021	OBJECTIVE/BACKGROUND: Mutations in transmembrane protease serine 6 (TMPRSS6) gene induce high hepcidin level, which causes iron-refractory iron deficiency anemia (IRIDA) by preventing duodenal iron absorption.	Iron	123-127	transmembrane serine protease 6	Homo sapiens	68-75
32446932-2	2021	This study aims to identify the common genetic variations of the TMPRSS6 gene that affect iron levels among Saudi female patients with iron deficiency anemia (IDA).	Iron	90-94	transmembrane serine protease 6	Homo sapiens	65-72
32895881-0	2021	The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder.	Iron	92-96	transferrin	Homo sapiens	39-41
33730930-1	2021	OBJECTIVES: Ferroptosis is caused by iron-dependent lipid peroxide accumulation, the sensitivity of which might be regulated by acyl-CoA synthetase long chain family member 4 (ACSL4).	Iron	37-41	acyl-CoA synthetase long chain family member 4	Homo sapiens	128-174
33730930-1	2021	OBJECTIVES: Ferroptosis is caused by iron-dependent lipid peroxide accumulation, the sensitivity of which might be regulated by acyl-CoA synthetase long chain family member 4 (ACSL4).	Iron	37-41	acyl-CoA synthetase long chain family member 4	Homo sapiens	176-181
33662397-6	2021	The structure together with DFT computational modeling demonstrate that 3HPA (and 3MPA) associate with iron as chelate complexes with the substrate-carboxylate group forming an additional interaction with Arg168 and the thiol bound at the same position as in CDO.	Iron	103-107	cell adhesion associated, oncogene regulated	Homo sapiens	259-262
31154873-8	2021	Using standard cutoffs of percent transferrin saturation and/or serum ferritin, 42% were observed to be iron deficient.	Iron	104-108	transferrin	Homo sapiens	34-45
33422672-1	2021	Iron has a key role in the activation of the autophagic pathway in rats with intracerebral hemorrhage (ICH), and hepcidin has the ability to reduce brain iron in ICH-rats.	Iron	154-158	hepcidin antimicrobial peptide	Rattus norvegicus	113-121
33422672-2	2021	We therefore hypothesized that hepcidin might be able to inhibit autophagy by reducing iron in an ICH brain.	Iron	87-91	hepcidin antimicrobial peptide	Rattus norvegicus	31-39
33422672-6	2021	Based on these findings plus previous data on the effects of ad-hepcidin and/or hepcidin peptide on iron contents in ICH models, we suggested that hepcidin-induced inhibition of autophagy might be mediated via reducing iron in hemin-treated neurons in vitro and ICH-rat brain in vivo.	Iron	100-104	hepcidin antimicrobial peptide	Rattus norvegicus	80-88
33422672-6	2021	Based on these findings plus previous data on the effects of ad-hepcidin and/or hepcidin peptide on iron contents in ICH models, we suggested that hepcidin-induced inhibition of autophagy might be mediated via reducing iron in hemin-treated neurons in vitro and ICH-rat brain in vivo.	Iron	100-104	hepcidin antimicrobial peptide	Rattus norvegicus	80-88
33568304-3	2021	Previously, we have demonstrated the relationship between the PAP/SAL1 retrograde signaling pathway, the activity of Strategy I Fe uptake genes (FIT, FRO2, IRT1), and ethylene signaling.	Iron	128-130	SAL1 phosphatase-like protein	Arabidopsis thaliana	66-70
33568304-8	2021	In this way, PAP/SAL1 mutants showed alterations in the biosynthesis of metabolites that mobilize Fe, which ultimately improved these plants ability to grow in alkaline soils.	Iron	98-100	SAL1 phosphatase-like protein	Arabidopsis thaliana	17-21
33670876-0	2021	Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2alpha-Ve-Cadherin Pathway.	Iron	12-16	cadherin 5	Homo sapiens	87-98
32932001-0	2021	Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.	Iron	24-28	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
32932001-1	2021	Iron plays a key role in secondary neuronal injury after intracerebral hemorrhage (ICH), and hepcidin is able to reduce brain iron in iron-overloaded rats by down-regulating iron transport proteins including ferroportin 1 and transferrin receptor 1.	Iron	126-130	hepcidin antimicrobial peptide	Rattus norvegicus	93-101
32932001-1	2021	Iron plays a key role in secondary neuronal injury after intracerebral hemorrhage (ICH), and hepcidin is able to reduce brain iron in iron-overloaded rats by down-regulating iron transport proteins including ferroportin 1 and transferrin receptor 1.	Iron	134-138	hepcidin antimicrobial peptide	Rattus norvegicus	93-101
32932001-1	2021	Iron plays a key role in secondary neuronal injury after intracerebral hemorrhage (ICH), and hepcidin is able to reduce brain iron in iron-overloaded rats by down-regulating iron transport proteins including ferroportin 1 and transferrin receptor 1.	Iron	134-138	solute carrier family 40 member 1	Rattus norvegicus	208-221
32932001-1	2021	Iron plays a key role in secondary neuronal injury after intracerebral hemorrhage (ICH), and hepcidin is able to reduce brain iron in iron-overloaded rats by down-regulating iron transport proteins including ferroportin 1 and transferrin receptor 1.	Iron	134-138	hepcidin antimicrobial peptide	Rattus norvegicus	93-101
32932001-1	2021	Iron plays a key role in secondary neuronal injury after intracerebral hemorrhage (ICH), and hepcidin is able to reduce brain iron in iron-overloaded rats by down-regulating iron transport proteins including ferroportin 1 and transferrin receptor 1.	Iron	134-138	solute carrier family 40 member 1	Rattus norvegicus	208-221
32932001-2	2021	These led us to hypothesize that hepcidin might reduce iron-mediated neurotoxicity by inhibiting iron accumulation in ICH brain.	Iron	55-59	hepcidin antimicrobial peptide	Rattus norvegicus	33-41
32932001-2	2021	These led us to hypothesize that hepcidin might reduce iron-mediated neurotoxicity by inhibiting iron accumulation in ICH brain.	Iron	97-101	hepcidin antimicrobial peptide	Rattus norvegicus	33-41
33544106-3	2021	Two composites of Ag/AgCl@MIL-88A(Fe), namely MAG-1 and MAG-2 (stoichiometric ratio of Fe to Ag is 5 : 1 and 2 : 1), were successfully synthesized via facile in situ hydrothermal methods followed by UV reduction.	Iron	34-36	glycerol-3-phosphate acyltransferase 3	Homo sapiens	46-51
33544106-3	2021	Two composites of Ag/AgCl@MIL-88A(Fe), namely MAG-1 and MAG-2 (stoichiometric ratio of Fe to Ag is 5 : 1 and 2 : 1), were successfully synthesized via facile in situ hydrothermal methods followed by UV reduction.	Iron	34-36	reticulophagy regulator family member 2	Homo sapiens	56-61
33544106-5	2021	The Ag/AgCl@MIL-88A(Fe) (MAG-2) hybrid system shows excellent photocatalytic activity for the degradation of p-nitrophenol (PNP), rhodamine B (RhB), and methylene blue (MB) under sunlight.	Iron	20-22	reticulophagy regulator family member 2	Homo sapiens	25-30
32932001-4	2021	We demonstrated that hepcidin could significantly suppress the ICH-induced increase in iron and ferritin in brain tissues and CSF by inhibiting expression of iron transport proteins, increase neuronal survival by attenuating ICH-induced apoptosis, reactive oxygen species, neurodegeneration and brain edema, as well as effectively improve ICH-induced behavioral and cognitive deficit in rats.	Iron	87-91	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
32932001-4	2021	We demonstrated that hepcidin could significantly suppress the ICH-induced increase in iron and ferritin in brain tissues and CSF by inhibiting expression of iron transport proteins, increase neuronal survival by attenuating ICH-induced apoptosis, reactive oxygen species, neurodegeneration and brain edema, as well as effectively improve ICH-induced behavioral and cognitive deficit in rats.	Iron	158-162	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
32932001-5	2021	The findings collectively showed that hepcidin could effectively attenuate iron-mediated secondary neuronal injury after ICH in rats.	Iron	75-79	hepcidin antimicrobial peptide	Rattus norvegicus	38-46
33544106-7	2021	The superior activity of Ag/AgCl@MIL-88A(Fe) (MAG-2) is attributed to the synergistic effects from the surface plasmon resonance (SPR) of Ag NPs and the electron transfer from MIL-88A(Fe) to Ag nanoparticles for effective separation of electron-hole pairs.	Iron	41-43	reticulophagy regulator family member 2	Homo sapiens	46-51
33670876-6	2021	We found that the iron chelator, Desferal  significantly decreased MRF and apoptosis subsequent to barrier insult, while also rescuing barrier integrity by inhibiting the labile iron pool increase, inducing HIF2alpha expression and preventing the degradation of Ve-cadherin specifically on the endothelial cell surface.	Iron	18-22	cadherin 5	Homo sapiens	262-273
33640456-2	2021	The cofactor that transfers the electrons directly to ubiquinone is an iron-sulfur cluster (N2) located in the NDUFS2/NUCM subunit.	Iron	71-75	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	111-117
33637889-4	2021	Some of these haplogroups, such as W3a1b that have been found in the ancient samples from the late Bronze Age to the Iron Age period individuals of Swat Valley northern Pakistan, even have sub-lineages (age ~4 kya old) in the southern subcontinent, consistent with the southward spread of Indo-Iranian languages.	Iron	117-121	renin binding protein	Homo sapiens	122-125
33607814-2	2021	Under iron overload, labile free non-transferrin-bound iron (NTBI) can induce cardiovascular damage with increased oxidative stress.	Iron	6-10	transferrin	Homo sapiens	37-48
33512156-4	2021	Using Fe-free and in situ Fe-doped ANF that were prepared in Fe-free and unpurified electrolytes, respectively, we investigated the interdependent effects of active surface area and transport properties on OER activity under practically high current densities.	Iron	26-28	natriuretic peptide A	Homo sapiens	35-38
33512156-4	2021	Using Fe-free and in situ Fe-doped ANF that were prepared in Fe-free and unpurified electrolytes, respectively, we investigated the interdependent effects of active surface area and transport properties on OER activity under practically high current densities.	Iron	26-28	natriuretic peptide A	Homo sapiens	35-38
33512156-5	2021	While activity increased linearly with active surface area for Fe-free ANF, the activity of Fe-doped ANF showed a nonlinear increase with active surface area due to lower electrocatalytic activity enhancement.	Iron	63-65	natriuretic peptide A	Homo sapiens	101-104
33512156-6	2021	Detailed investigations on the possible factors (Fe incorporation, mass transport, and electron transport) identified that electron transport limitations played the major role in restricting the activity enhancement with increasing active surface area for Fe-doped ANF, although Fe-doped ANF has electron transport properties better than those of Fe-free ANF.	Iron	49-51	natriuretic peptide A	Homo sapiens	265-268
33512156-6	2021	Detailed investigations on the possible factors (Fe incorporation, mass transport, and electron transport) identified that electron transport limitations played the major role in restricting the activity enhancement with increasing active surface area for Fe-doped ANF, although Fe-doped ANF has electron transport properties better than those of Fe-free ANF.	Iron	256-258	natriuretic peptide A	Homo sapiens	265-268
33512156-6	2021	Detailed investigations on the possible factors (Fe incorporation, mass transport, and electron transport) identified that electron transport limitations played the major role in restricting the activity enhancement with increasing active surface area for Fe-doped ANF, although Fe-doped ANF has electron transport properties better than those of Fe-free ANF.	Iron	256-258	natriuretic peptide A	Homo sapiens	265-268
33512156-6	2021	Detailed investigations on the possible factors (Fe incorporation, mass transport, and electron transport) identified that electron transport limitations played the major role in restricting the activity enhancement with increasing active surface area for Fe-doped ANF, although Fe-doped ANF has electron transport properties better than those of Fe-free ANF.	Iron	256-258	natriuretic peptide A	Homo sapiens	265-268
33692679-8	2021	The results support the involvement of iron dysregulation and its potential interaction with biomarkers (Tau protein and Amyloid-beta) in the pathophysiology and progression of dementia.	Iron	39-43	amyloid beta precursor protein	Homo sapiens	121-133
33514951-3	2021	Tl2(OCtBu2Ph)2 serves as a convenient precursor to the formation of old and new [M(OCtBu2Ph)n] complexes (M = Cr, Fe, Cu, Zn), including a rare example of T-shaped Zn(OCtBu2Ph)2(THF) complex, which could not be previously synthesized using more conventional LiOR/HOR precursors.	Iron	114-116	TNF superfamily member 10	Homo sapiens	0-14
33607942-6	2021	RESULTS: Multiple stepwise regression analysis demonstrated that albumin levels were significantly and independently associated with age (inversely), systolic blood pressures, estimated glomerular filtration rate (eGFR), MMSE score, frailty measures (handgrip strength), an inflammation marker (high-sensitivity C-reactive protein), hormones (growth hormone (inversely) and insulin-like growth factor-1), and trace elements (calcium, magnesium, iron, and zinc), with a linear trend.	Iron	445-449	albumin	Homo sapiens	65-72
33607814-2	2021	Under iron overload, labile free non-transferrin-bound iron (NTBI) can induce cardiovascular damage with increased oxidative stress.	Iron	55-59	transferrin	Homo sapiens	37-48
33596034-0	2021	Spectroscopic characterization of the interactions of bovine serum albumin with medicinally important metal ions: platinum (IV), iridium (III) and iron (II).	Iron	147-151	albumin	Homo sapiens	61-74
33597025-1	2021	Brain iron accumulation has been found to accelerate disease progression in amyloid-beta(Abeta) positive Alzheimer patients, though the mechanism is still unknown.	Iron	6-10	amyloid beta precursor protein	Homo sapiens	89-94
33597025-8	2021	These findings suggest iron to be taken up by microglia and to influence the functional phenotype of these cells, especially in conjunction with Abeta.	Iron	23-27	amyloid beta precursor protein	Homo sapiens	145-150
33596964-3	2021	Here we present a case where a simple heterozygote in combination with alcoholism developed high ferritin and high transferrin saturation levels indicative of iron overload.	Iron	159-163	transferrin	Homo sapiens	115-126
33597529-0	2021	Short-lived metal-centered excited state initiates iron-methionine photodissociation in ferrous cytochrome c.	Iron	51-55	cytochrome c, somatic	Homo sapiens	96-108
33597529-2	2021	We report a study of the photodissociation mechanism for the Fe(II)-S bond between the heme iron and methionine sulfur of ferrous cytochrome c.	Iron	92-96	cytochrome c, somatic	Homo sapiens	130-142
33593088-2	2021	Inflammation also decreases the concentration of transferrin, the main iron transport protein and a negative acute phase protein, which is indirectly assessed by measuring total iron binding capacity (TIBC).	Iron	71-75	transferrin	Homo sapiens	49-60
33593088-2	2021	Inflammation also decreases the concentration of transferrin, the main iron transport protein and a negative acute phase protein, which is indirectly assessed by measuring total iron binding capacity (TIBC).	Iron	178-182	transferrin	Homo sapiens	49-60
33665641-4	2021	We examined humoral immunity in human patients with raised hepcidin and low serum iron caused by mutant TMPRSS6.	Iron	82-86	transmembrane serine protease 6	Homo sapiens	104-111
33593088-11	2021	In conclusion, inflammatory diets may impair iron status by reducing the iron binding capacity of transferrin.	Iron	45-49	transferrin	Homo sapiens	98-109
33593088-11	2021	In conclusion, inflammatory diets may impair iron status by reducing the iron binding capacity of transferrin.	Iron	73-77	transferrin	Homo sapiens	98-109
33073884-2	2021	Alongside clinical platinum drugs, these bimetallic ruthenium-iron complexes have been screened for their cytotoxicity against MIA PaCa-2 (human pancreatic carcinoma), HCT116 p53+/+ (human colon carcinoma, p53-wild type) and ARPE-19 (human retinal pigment epithelial) cell lines.	Iron	62-66	tumor protein p53	Homo sapiens	175-178
33597821-14	2021	CRLR/CGRPR1 expression might be related to altered iron homeostasis and they both may stimulate nociceptive pathways activated in migraine.	Iron	51-55	calcitonin receptor like receptor	Homo sapiens	0-4
33576020-8	2021	Replacement the iron centre of the heme group with cobalt nullified the effect of His-CYGB.	Iron	16-20	cytoglobin	Homo sapiens	82-90
33022342-14	2021	CONCLUSIONS: SFE regulated iron metabolism by inhibiting hepcidin and simultaneously promoted EPO synthesis to improve renal anaemia in rats.	Iron	27-31	hepcidin antimicrobial peptide	Rattus norvegicus	57-65
33633672-1	2021	Objectives: Free irons are transported into brain tissues by transferrin and play an important role in neuronal/glial cell damage.	Iron	17-22	transferrin	Homo sapiens	61-72
33549104-8	2021	In the semiquantitative methods, both peritumoral and background liver iron deposition grade were significantly higher in HCCs with a PTHR compared with HCCs without a PTHR (P < 0.001).	Iron	71-75	holocytochrome c synthase	Homo sapiens	122-126
33549104-9	2021	The mean optical density in HCCs with a PTHR was significantly higher compared with HCCs without a PTHR, in the quantitative peritumoral (42,244.1 +- 20,854.9 vs. 18,739.1 +- 12,258.7, respectively; P < 0.001) and background liver iron deposition analyses (35,554.7 +- 19,854.8 vs. 17,292.4 +- 11,605.8, respectively; P < 0.001).	Iron	231-235	holocytochrome c synthase	Homo sapiens	28-32
33549104-11	2021	CONCLUSIONS: A PTHR in HCCs on T2*WIs was strongly associated with peritumoral iron deposition in the iron-deposited background liver but not with the fibrous capsule.	Iron	79-83	holocytochrome c synthase	Homo sapiens	23-27
33549104-11	2021	CONCLUSIONS: A PTHR in HCCs on T2*WIs was strongly associated with peritumoral iron deposition in the iron-deposited background liver but not with the fibrous capsule.	Iron	102-106	holocytochrome c synthase	Homo sapiens	23-27
33264886-7	2021	The co-existence of Fe and Co in various valence states in catalyst might improve the conversion of Co(III)/Co(II) and Fe(III)/Fe(II), which would increase the catalytic activity in catalytic ozonation process.	Iron	20-22	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	100-107
33540396-0	2021	Anti-CEA tagged iron nanoparticles for targeting triple-negative breast cancer.	Iron	16-20	carcinoembryonic antigen gene family	Mus musculus	5-8
33264886-7	2021	The co-existence of Fe and Co in various valence states in catalyst might improve the conversion of Co(III)/Co(II) and Fe(III)/Fe(II), which would increase the catalytic activity in catalytic ozonation process.	Iron	20-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
33264886-7	2021	The co-existence of Fe and Co in various valence states in catalyst might improve the conversion of Co(III)/Co(II) and Fe(III)/Fe(II), which would increase the catalytic activity in catalytic ozonation process.	Iron	20-22	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	103-106
33536631-4	2021	Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload.	Iron	58-62	dual oxidase 2	Homo sapiens	12-17
33393230-6	2021	Mechanistically, OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transportation through deubiquitinating and stabilizing IREB2, leading to increased ROS generation and ferroptosis.	Iron	79-83	iron responsive element binding protein 2	Homo sapiens	140-145
33393230-9	2021	Our data demonstrate that OTUD1 plays a stimulatory role in iron transportation and highlight the importance of OTUD1-IREB2-TFRC signaling axis in host antitumor immunity.	Iron	60-64	iron responsive element binding protein 2	Homo sapiens	118-123
33536631-4	2021	Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload.	Iron	58-62	transmembrane serine protease 6	Homo sapiens	35-42
33536631-6	2021	The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%.	Iron	84-88	dual oxidase 2	Homo sapiens	4-9
33212230-0	2021	Use of 2-dimensional cell monolayers and 3-dimensional microvascular networks on microfluidic devices shows that iron increases transendothelial adiponectin flux via inducing ROS production.	Iron	113-117	adiponectin, C1Q and collagen domain containing	Homo sapiens	145-156
32886889-3	2021	LTF is an iron-binding glycoprotein that binds Fe3+ with high affinity.	Iron	10-14	lactotransferrin	Homo sapiens	0-3
32886889-4	2021	Unlike other iron binding proteins, LTF can retain Fe3+ at the low pH associated with inflamed tissue.	Iron	13-17	lactotransferrin	Homo sapiens	36-39
32886889-5	2021	LTF"s ability to sequester Fe3+ is of particular importance to ICH pathogenesis, as large quantities of free iron, which is pro-oxidative and pro-inflammatory are generated in the ICH-affected brain due to blood hemolysis.	Iron	109-113	lactotransferrin	Homo sapiens	0-3
33528512-6	2021	Interestingly, the excess Zn symptoms of atg5 were alleviated by supplementation of high levels of iron (Fe) to the media.	Iron	99-103	autophagy protein Apg5 family	Arabidopsis thaliana	41-45
33528512-6	2021	Interestingly, the excess Zn symptoms of atg5 were alleviated by supplementation of high levels of iron (Fe) to the media.	Iron	105-107	autophagy protein Apg5 family	Arabidopsis thaliana	41-45
32363518-1	2021	Body iron status is likely to be associated with type 2 diabetes (T2DM) and gestational diabetes mellitus (GDM); transmembrane protease serine 6 (TMPRSS6) polymorphisms may be associated with T2DM risk through their effects on body iron status.	Iron	232-236	transmembrane serine protease 6	Homo sapiens	113-144
32363518-1	2021	Body iron status is likely to be associated with type 2 diabetes (T2DM) and gestational diabetes mellitus (GDM); transmembrane protease serine 6 (TMPRSS6) polymorphisms may be associated with T2DM risk through their effects on body iron status.	Iron	232-236	transmembrane serine protease 6	Homo sapiens	146-153
32363518-4	2021	The two SNPs in TMPRSS6 gene were genotyped and examined for their associations with body iron status and GDM risk in 398 unrelated Chinese Han pregnant women.	Iron	90-94	transmembrane serine protease 6	Homo sapiens	16-23
32363518-5	2021	The 2 TMPRSS6 SNPs rs855791 and rs4820268 were both significantly associated with serum iron and transferrin saturation (P < 0.01 for all) rather than ferritin.	Iron	88-92	transmembrane serine protease 6	Homo sapiens	6-13
32363518-8	2021	The 2 TMPRSS6 SNPs rs855791 and rs4820268 were both significantly associated with serum iron and transferrin saturation, and TMPRSS6 variants might be associated with the risk of GDM.	Iron	88-92	transmembrane serine protease 6	Homo sapiens	6-13
33212230-1	2021	BACKGROUND: Iron excess is a risk factor for cardiovascular diseases and it is important to understand the effect of iron on vascular permeability, particularly for the transport of large metabolic hormones such as adiponectin.	Iron	12-16	adiponectin, C1Q and collagen domain containing	Homo sapiens	215-226
33212230-1	2021	BACKGROUND: Iron excess is a risk factor for cardiovascular diseases and it is important to understand the effect of iron on vascular permeability, particularly for the transport of large metabolic hormones such as adiponectin.	Iron	117-121	adiponectin, C1Q and collagen domain containing	Homo sapiens	215-226
33212230-4	2021	Flux analysis indicated that under control conditions permeability of 70 kDa dextran and oligomeric forms of adiponectin were restricted in comparison with a 3 kDa dextran, however upon iron treatment permeability of the larger molecules was increased.	Iron	186-190	adiponectin, C1Q and collagen domain containing	Homo sapiens	109-120
33616338-5	2021	RESULTS: Serum ferritin and transferrin showed variations from -2.6 to 2.6% and -1.7 to 2.4%, respectively, in their concentrations during the three freeze-thaw cycles of -20 C and -80 C. However, the variations were statistically significant only at -20 C. No significant changes were found for iron at both temperatures.	Iron	296-300	transferrin	Homo sapiens	28-39
33017703-7	2021	Nrf2 activation enhanced iron storage capacity and GPX4 activity by elevating ferritin heavy chain 1 (FTH1) expression and glutathione (GSH) level, respectively.	Iron	25-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
33017703-7	2021	Nrf2 activation enhanced iron storage capacity and GPX4 activity by elevating ferritin heavy chain 1 (FTH1) expression and glutathione (GSH) level, respectively.	Iron	25-29	ferritin heavy chain 1	Rattus norvegicus	78-100
33017703-7	2021	Nrf2 activation enhanced iron storage capacity and GPX4 activity by elevating ferritin heavy chain 1 (FTH1) expression and glutathione (GSH) level, respectively.	Iron	25-29	ferritin heavy chain 1	Rattus norvegicus	102-106
33616338-7	2021	CONCLUSIONS: Serum iron, ferritin, and transferrin were affected by the storage of samples at temperatures of 4 C, -20 C and -80 C for up to 4 weeks, and the freeze-thaw cycles at -20 C influenced the measurement of serum ferritin and transferrin.	Iron	19-23	transferrin	Homo sapiens	235-246
33166496-4	2021	Primary human articular chondrocyte was employed as a model for in vitro assessment of IL-6 effects in cell viability, cellular oxidative stress and iron homeostasis by MTT, MDA, ROS and Iron Colorimetric assays.	Iron	149-153	interleukin 6	Homo sapiens	87-91
33166496-4	2021	Primary human articular chondrocyte was employed as a model for in vitro assessment of IL-6 effects in cell viability, cellular oxidative stress and iron homeostasis by MTT, MDA, ROS and Iron Colorimetric assays.	Iron	187-191	interleukin 6	Homo sapiens	87-91
33166496-8	2021	IL-6 exposure caused cartilage cell ferroptosis by inducing cellular oxidative stress and disturbing iron homeostasis.	Iron	101-105	interleukin 6	Homo sapiens	0-4
31919080-1	2021	The erythropoietin (Epo)-erythroferrone (ERFE)-hepcidin axis coordinates erythropoiesis and iron homeostasis.	Iron	92-96	erythropoietin	Homo sapiens	4-18
33200454-4	2021	In our study, we found that ferroportin1 (FPN1), the only known cellular iron export protein in mammals, and ablation in neurons and astrocytes caused iron deficiency in the cortex and hippocampus.	Iron	73-77	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	28-40
33200454-4	2021	In our study, we found that ferroportin1 (FPN1), the only known cellular iron export protein in mammals, and ablation in neurons and astrocytes caused iron deficiency in the cortex and hippocampus.	Iron	73-77	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	42-46
33200454-6	2021	Moreover, direct evidence of the role of FPN1, or the related molecular mechanisms of such a role, in balancing brain iron homeostasis, especially in neuronal cells, is lacking.	Iron	118-122	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	41-45
33200454-9	2021	We also found that FPN1 ablation in neurons and astrocytes caused an atypical expression of iron metabolism-related proteins in these two regions: decreased expression of DMT1, Ft-H, and Ft-L, and increased TfR1 expression.	Iron	92-96	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	19-23
33200454-10	2021	In addition, the decreased FPN1 in brain microvascular endothelial cells (BMVECs) also shed light on the cause of the decreased iron delivery to the brain through the blood-brain barrier (BBB).	Iron	128-132	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	27-31
33200454-11	2021	Our research highlights the major role played by FPN1 in brain iron homeostasis and identifies a potential target for the treatment of PTSD.	Iron	63-67	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	49-53
32193252-9	2021	Accordingly, iron sequestration in liver and spleen caused by TLR4 activation was completely abrogated by FGF23 signaling inhibition, resulting in alleviation of serum iron and transferrin saturation deficit.	Iron	13-17	toll-like receptor 4	Mus musculus	62-66
32193252-9	2021	Accordingly, iron sequestration in liver and spleen caused by TLR4 activation was completely abrogated by FGF23 signaling inhibition, resulting in alleviation of serum iron and transferrin saturation deficit.	Iron	168-172	toll-like receptor 4	Mus musculus	62-66
31919080-1	2021	The erythropoietin (Epo)-erythroferrone (ERFE)-hepcidin axis coordinates erythropoiesis and iron homeostasis.	Iron	92-96	erythropoietin	Homo sapiens	20-23
33420375-3	2021	Herein, we identified coatomer protein complex subunit zeta 1 (COPZ1) as a therapeutic target candidate which significantly dysregulated iron metabolism in GBM cells.	Iron	137-141	COPI coat complex subunit zeta 1	Homo sapiens	22-61
33420375-10	2021	These data demonstrate that COPZ1 is a critical mediator in iron metabolism.	Iron	60-64	COPI coat complex subunit zeta 1	Homo sapiens	28-33
33049075-4	2021	New evidence points to involvement of the hypoxia-inducible factor (HIF)/erythropoietin (EPO)/iron pathway as important in FGF23 physiology.	Iron	94-98	erythropoietin	Homo sapiens	73-87
33049075-4	2021	New evidence points to involvement of the hypoxia-inducible factor (HIF)/erythropoietin (EPO)/iron pathway as important in FGF23 physiology.	Iron	94-98	erythropoietin	Homo sapiens	89-92
33279052-0	2021	Stability of Fe-As composites formed with As(V) and aged ferrihydrite.	Iron	13-15	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	42-47
33420375-3	2021	Herein, we identified coatomer protein complex subunit zeta 1 (COPZ1) as a therapeutic target candidate which significantly dysregulated iron metabolism in GBM cells.	Iron	137-141	COPI coat complex subunit zeta 1	Homo sapiens	63-68
33690026-0	2021	Changes in iron metabolism centered on hepcidin due to high-intensity exercise under restricted food intake.	Iron	11-15	hepcidin antimicrobial peptide	Rattus norvegicus	39-47
33333051-11	2021	The inhibitory effect of CA on ferroptosis probably was partially governed by activation of Nrf2 to regulate the GSH synthesis and metabolism and cellular iron homeostasis.	Iron	155-159	NFE2 like bZIP transcription factor 2	Rattus norvegicus	92-96
33503419-5	2021	Vesicular delivery of iron by transferrin more efficiently promotes P. aeruginosa biofilm growth than soluble holo-transferrin delivered alone.	Iron	22-26	transferrin	Homo sapiens	30-41
33047410-6	2021	In addition, plants that absorb more NO3 - than NH4 + increase the soil pH and decrease the availability of iron (Fe), manganese (Mn), and zinc (Zn).	Iron	108-112	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
33047410-6	2021	In addition, plants that absorb more NO3 - than NH4 + increase the soil pH and decrease the availability of iron (Fe), manganese (Mn), and zinc (Zn).	Iron	114-116	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
33047410-11	2021	Leaf delta15 N values correlated negatively with Fe, relating to decreases in soil Fe availability, which might be attributed to oxidation of Fe2+ to Fe3+ supplying electrons for denitrification, and more uptake of NO3 - than NH4 + of plants increases soil pH.	Iron	49-51	NBL1, DAN family BMP antagonist	Homo sapiens	215-218
33503419-4	2021	Respiratory syncytial virus (RSV) increases the release of the host iron-binding protein transferrin on the extravesicular face of EVs, which interact with P. aeruginosa biofilms to transfer the nutrient iron and promote bacterial biofilm growth.	Iron	68-72	transferrin	Homo sapiens	89-100
33503419-4	2021	Respiratory syncytial virus (RSV) increases the release of the host iron-binding protein transferrin on the extravesicular face of EVs, which interact with P. aeruginosa biofilms to transfer the nutrient iron and promote bacterial biofilm growth.	Iron	204-208	transferrin	Homo sapiens	89-100
33717836-7	2021	Particularly, the structurally optimized HSAC/Fe-3 displays a maximum power density of up to 824 mW cm-2, higher than other samples with fewer mesopores.	Iron	46-48	adenylate cyclase 10	Homo sapiens	41-45
33494856-5	2021	Iron status was measured as non-fasting plasma ferritin (P-Fe) and transferrin in gestational week 18 (n=2990), and by lowest reported haemoglobin (Hb) in gestational weeks 0-30 (n=39,322).	Iron	0-4	transferrin	Homo sapiens	67-78
33503419-5	2021	Vesicular delivery of iron by transferrin more efficiently promotes P. aeruginosa biofilm growth than soluble holo-transferrin delivered alone.	Iron	22-26	transferrin	Homo sapiens	115-126
33860145-2	2021	Methods: We evaluated preoperative transferrin, which was calculated as iron and unsaturated iron-binding capacity, in 501 patients who underwent surgery for Stage I-III CRC.	Iron	72-76	transferrin	Homo sapiens	35-46
33491917-8	2021	The genes implicated in familial AD are not known to influence ferroptosis, although recent reports on APP mutations and apolipoprotein E allele (APOE) have shown impact on cellular iron retention.	Iron	182-186	apolipoprotein E	Homo sapiens	121-137
33491917-8	2021	The genes implicated in familial AD are not known to influence ferroptosis, although recent reports on APP mutations and apolipoprotein E allele (APOE) have shown impact on cellular iron retention.	Iron	182-186	apolipoprotein E	Homo sapiens	146-150
33491917-12	2021	Tau, APP, and apoE have been implicated in physiological iron homeostasis in the brain.	Iron	57-61	apolipoprotein E	Homo sapiens	14-18
33860145-2	2021	Methods: We evaluated preoperative transferrin, which was calculated as iron and unsaturated iron-binding capacity, in 501 patients who underwent surgery for Stage I-III CRC.	Iron	93-97	transferrin	Homo sapiens	35-46
33860145-3	2021	Transferrin level was directly proportional to total iron-binding capacity (TIBC), and TIBC < 250 mug/dl was defined as low transferrin.	Iron	53-57	transferrin	Homo sapiens	0-11
33584308-0	2020	Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.	Iron	14-18	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
33584308-11	2020	In conclusion, our results demonstrated that mitochondrial iron overload-mediated antioxidant system inhibition would assist ALI-induced ferroptosis in renal tubular epithelial cells, and Nrf2-HO-1/GPX4 antioxidative system could be an important intervention target to prevent medicine containing ALI-induced nephropathy.	Iron	59-63	NFE2 like bZIP transcription factor 2	Homo sapiens	188-192
33498292-8	2021	FPC transports iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration.	Iron	15-19	transferrin	Homo sapiens	32-43
33520115-7	2021	In addition to this, iron chelators stimulate apoptotic and ER stress signalling pathways inducing cell death even in cells lacking a functional p53 gene.	Iron	21-25	tumor protein p53	Homo sapiens	145-148
32896728-0	2021	As(V) adsorption by a novel core-shell magnetic nanoparticles prepared with Iron-containing water treatment residuals.	Iron	76-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
33520115-8	2021	Iron chelators can sensitise cancer cells to PARP inhibitors through mimicking BRCAness; a feature of cancers trademark genomic instability.	Iron	0-4	poly(ADP-ribose) polymerase 1	Homo sapiens	45-49
33378193-0	2021	Hydrogen-Bond-Assisted Alignment of [MCu(SeO3)4Cl(H2O)]4- (M = Fe, Ga) Anionic Layers to Form Two Polar Oxychlorides: Pb2MCu(SeO3)4Cl(H2O).	Iron	63-65	mitochondrial calcium uniporter	Homo sapiens	37-40
33373853-5	2021	Here, we show that pirin (PIR), an iron-binding nuclear protein, plays a previously unrecognized role in mediating ferroptosis resistance in human pancreatic cancer cells.	Iron	35-39	pirin	Homo sapiens	19-24
33396131-10	2021	NaF treatment increased the degradation of heme causing release of free iron from its porphyrin ring.	Iron	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
32905031-7	2021	Further, the high-resolution Mn 2p, Zn 2p, Fe 2p, and O 1s spectra of Mn1-xZnxFe2O4 does not result in the appearance of new peaks with Zn content, indicating that the Zn substitution does not change the ionic state of Mn, Zn, Fe, and O present in nanocrystalline Mn1-xZnxFe2O4.	Iron	78-80	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	70-73
32683153-0	2021	Characteristics and mechanisms of Pb(II) sorption onto Fe-rich waste water treatment residue (WTR): A potential sustainable Pb immobilisation technology for soils.	Iron	55-57	submaxillary gland androgen regulated protein 3B	Homo sapiens	34-40
32683153-2	2021	This paper discusses the ability of an Fe-rich waste, water treatment residual (WTR), to adsorb Pb(II).	Iron	39-41	submaxillary gland androgen regulated protein 3B	Homo sapiens	96-102
32683153-12	2021	Therefore, we suggest that Fe-rich WTR wastes could be used as effective adsorbents in Pb(II)-contaminated soils to help ensure sustainable terrestrial ecosystems.	Iron	27-29	submaxillary gland androgen regulated protein 3B	Homo sapiens	87-93
33452385-1	2021	We report on interfacial characteristics and chemistry of bonded Mg-Fe interfaces welded using friction stir assisted scribe technique (FaST).	Iron	68-70	Fas activated serine/threonine kinase	Homo sapiens	136-140
33435886-7	2021	Iron loading decreased SIRT3 protein expression, promoted an increase in SOD2, and led to the elevation of mROS.	Iron	0-4	sirtuin 3	Homo sapiens	23-28
33356252-0	2021	DFT Investigation of the eta6   eta6-Inter-ring Haptotropic Rearrangement of the Group 8 Metals Complexes [(graphene)MCp]+ (M = Fe, Ru, Os).	Iron	128-130	CD46 molecule	Homo sapiens	117-120
33356252-1	2021	Metalcyclopentadienyl complexes (MCp)+ (M = Fe, Ru, Os) bound to the large polyaromatic hydrogenated hydrocarbon (PAH) C96H24 used as a model for pristine graphene have been studied using a density functional theory (DFT) generalized gradient approximation (PBE functional) to reveal their structural features and dynamic behavior.	Iron	44-46	CD46 molecule	Homo sapiens	33-36
33356252-3	2021	The energy barriers of the eta6   eta6 IRHRs of the (MCp)+ unit were found to be 30, 27, and 29 kcal/mol for M = Fe, Ru, and Os, respectively.	Iron	113-115	CD46 molecule	Homo sapiens	53-56
33446747-7	2021	After iron supplementation, serum iron, transferrin saturation and serum ferritin levels were increased compared with the IDA group.	Iron	6-10	transferrin	Rattus norvegicus	40-51
33404288-8	2021	Additionally, the intracellular iron exporter SLC40A1 was identified as a new substrate for autophagic elimination, and its degradation by SQSTM1 promoted ferroptosis in vitro and in xenograft tumor mouse models.	Iron	32-36	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	46-53
33441545-0	2021	Intranasal administration of alpha-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis.	Iron	83-87	alpha-synuclein	Macaca fascicularis	29-44
33519502-5	2020	We induced acute local pulmonary inflammation via aerosolized LPS in a mouse model of hereditary hemochromatosis type 4 (Slc40a1 C326S/C326S), which is hallmarked by systemic and pulmonary iron accumulation, specifically in alveolar macrophages.	Iron	189-193	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	121-128
33436675-1	2021	Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be membrane-anchored or secreted in serum.	Iron	30-34	transferrin	Homo sapiens	6-17
33436675-2	2021	On cells, it can mediate transferrin-independent iron uptake and promote proliferation.	Iron	49-53	transferrin	Homo sapiens	25-36
33436675-7	2021	The MTf N-lobe is in an active and iron-bound, closed conformation while the C-lobe is in an open conformation incompatible with iron binding.	Iron	35-39	melanotransferrin	Mus musculus	4-7
33436675-7	2021	The MTf N-lobe is in an active and iron-bound, closed conformation while the C-lobe is in an open conformation incompatible with iron binding.	Iron	129-133	melanotransferrin	Mus musculus	4-7
33405078-7	2021	Our analysis demonstrated a significantly decreased level of Fe, Zn, and Se among human CL and canine leishmaniasis, and Zn and Fe in patients with VL.	Iron	128-130	modulator of VRAC current 1	Homo sapiens	148-150
33585112-2	2021	The cart sped up and he lost control and toppled in front of the iron wheel, which ran over his lower limb around the knee.	Iron	65-69	CART prepropeptide	Homo sapiens	4-8
33837742-6	2021	Notably, iron levels were elevated in the neural retina and retinal pigment epithelial (RPE) cells of Abca4-/- mice.	Iron	9-13	ATP-binding cassette, sub-family A (ABC1), member 4	Mus musculus	102-107
33297278-6	2021	The addition of Fe3+ and CTAB(cetyl trimethyl ammonium bromide) reagents make the precipitate particles aggregated to flocs(MHA-Fe, MHA-Fe-CTAB) much more large, loose, coarse, and small-density.	Iron	16-18	myosin heavy chain 9	Homo sapiens	124-127
33402423-6	2021	Notably, iron levels were elevated in the neural retina and RPE of Abca4-/- mice.	Iron	9-13	ATP-binding cassette, sub-family A (ABC1), member 4	Mus musculus	67-72
33207934-1	2021	OBJECTIVE: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the degradation of heme to carbon monoxide, iron, and biliverdin.	Iron	122-126	heme oxygenase 1	Mus musculus	11-16
33207934-1	2021	OBJECTIVE: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the degradation of heme to carbon monoxide, iron, and biliverdin.	Iron	122-126	heme oxygenase 1	Mus musculus	18-34
32215811-0	2021	Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1alpha/MAPK Pathway in the Liver.	Iron	18-22	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	44-57
32215811-8	2021	Our findings confirmed that fasting increases iron export in the liver by upregulating Fpn1 expression through the ghrelin/GHSR1alpha/MAPK signaling pathway.	Iron	46-50	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	87-91
33075723-3	2021	Then, PEI and luminol were simultaneously immobilized on Ni-TCPP (Fe) nanosheets to construct self-enhanced solid state luminophore (Ni-TCPP (Fe)-PEI-Lum), possessing desirable stability and high ECL efficiency.	Iron	66-68	lumican	Homo sapiens	150-153
33075723-3	2021	Then, PEI and luminol were simultaneously immobilized on Ni-TCPP (Fe) nanosheets to construct self-enhanced solid state luminophore (Ni-TCPP (Fe)-PEI-Lum), possessing desirable stability and high ECL efficiency.	Iron	142-144	lumican	Homo sapiens	150-153
33705282-5	2021	The alkaline isomerization of cyt c in the presence of 8 M urea, measured by Trp59 fluorescence, implied an existence of a high-affinity non-native ligand for the heme iron even in a partially denatured protein conformation.	Iron	168-172	cytochrome c, somatic	Homo sapiens	30-35
33705282-8	2021	The high affinity of the sixth ligand for the heme iron is likely a reason of the lack of peroxidase activity of cyt c in the alkaline state.	Iron	51-55	cytochrome c, somatic	Homo sapiens	113-118
33297278-6	2021	The addition of Fe3+ and CTAB(cetyl trimethyl ammonium bromide) reagents make the precipitate particles aggregated to flocs(MHA-Fe, MHA-Fe-CTAB) much more large, loose, coarse, and small-density.	Iron	16-18	myosin heavy chain 9	Homo sapiens	132-135
32281155-2	2021	Could skeletal muscle be involved in microgravity-induced iron misdistribution by modulating hepcidin expression, the master regulator of iron metabolism?	Iron	138-142	hepcidin antimicrobial peptide	Rattus norvegicus	93-101
31264511-6	2021	The reaction time in which oxygen evolution happpens depends on the concentration of catalyst used in the oxidation, verifying that the highest oxygen generation rates are obtained when applying [Fe]0 = 10.0 mg L-1.	Iron	196-198	L1 cell adhesion molecule	Homo sapiens	211-214
31264511-8	2021	The stages of formation and decrease of oxygen are adjusted to zero-order kinetics, estimating the kinetics constants as a function of the catalyst concentration: kf = 29.48 [Fe]0-1.25 (mg O2 L-1 min-1) and kd = -0.006 [Fe]0 2.0 + 0.244 [Fe]0-3.69 (mg O2 L-1 min-1).	Iron	175-177	L1 cell adhesion molecule	Homo sapiens	192-195
31264511-8	2021	The stages of formation and decrease of oxygen are adjusted to zero-order kinetics, estimating the kinetics constants as a function of the catalyst concentration: kf = 29.48 [Fe]0-1.25 (mg O2 L-1 min-1) and kd = -0.006 [Fe]0 2.0 + 0.244 [Fe]0-3.69 (mg O2 L-1 min-1).	Iron	175-177	L1 cell adhesion molecule	Homo sapiens	255-258
33463069-9	2021	In addition, apolipoprotein E knockout mice were fed chow with a different iron content, and angiotensin II (Ang II) was used to induce AMD.	Iron	75-79	apolipoprotein E	Mus musculus	13-29
32281155-6	2021	We previously observed in rats that during simulated microgravity for 7 days, hepcidin plays a key role in iron misdistribution, and suggested that a crosstalk between skeletal muscle and liver could regulate hepcidin synthesis in this context.	Iron	107-111	hepcidin antimicrobial peptide	Rattus norvegicus	78-86
33682709-3	2021	OBJECTIVE: To determine whether an imbalance of iron and the proteins involved in its metabolism (ceruloplasmin and transferrin) are linked to Alzheimer"s disease (AD) and to the expression of amyloid-beta (Abeta) peptide 1-42 (Abeta 1-42), which is a major species of Abeta, and the most toxic.	Iron	48-52	amyloid beta precursor protein	Homo sapiens	193-205
33248265-0	2021	Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice.	Iron	28-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
33248265-2	2021	The association between Nrf2 activity and iron-related oxidative stress in neurodegenerative diseases has been studied, and Nrf2 was found to transcriptionally regulate the expression of iron transporters and ferroptosis-related factors.	Iron	42-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-28
33248265-2	2021	The association between Nrf2 activity and iron-related oxidative stress in neurodegenerative diseases has been studied, and Nrf2 was found to transcriptionally regulate the expression of iron transporters and ferroptosis-related factors.	Iron	42-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
33248265-2	2021	The association between Nrf2 activity and iron-related oxidative stress in neurodegenerative diseases has been studied, and Nrf2 was found to transcriptionally regulate the expression of iron transporters and ferroptosis-related factors.	Iron	187-191	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-28
33248265-2	2021	The association between Nrf2 activity and iron-related oxidative stress in neurodegenerative diseases has been studied, and Nrf2 was found to transcriptionally regulate the expression of iron transporters and ferroptosis-related factors.	Iron	187-191	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
33248265-3	2021	However, the role of Nrf2 in age-related motor dysfunction and its link to iron metabolism dysregulation in brain have not been fully elucidated.	Iron	75-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
33248265-6	2021	With high-iron and Parkinson"s disease (PD) mouse models, we revealed that Nrf2 KO prevented the deposition of brain iron, particularly in SN and striatum, which may subsequently delay motor dysfunction in aged mice.	Iron	10-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
33248265-6	2021	With high-iron and Parkinson"s disease (PD) mouse models, we revealed that Nrf2 KO prevented the deposition of brain iron, particularly in SN and striatum, which may subsequently delay motor dysfunction in aged mice.	Iron	117-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
33248265-7	2021	The regulation of Nrf2 KO on brain iron metabolism was likely mediated by decreasing the ferroportin 1 (FPN1) level on brain microvascular endothelial cells, thus hindering the process of iron entry into the brain.	Iron	35-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
33248265-7	2021	The regulation of Nrf2 KO on brain iron metabolism was likely mediated by decreasing the ferroportin 1 (FPN1) level on brain microvascular endothelial cells, thus hindering the process of iron entry into the brain.	Iron	35-39	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	89-102
33248265-7	2021	The regulation of Nrf2 KO on brain iron metabolism was likely mediated by decreasing the ferroportin 1 (FPN1) level on brain microvascular endothelial cells, thus hindering the process of iron entry into the brain.	Iron	35-39	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	104-108
33248265-7	2021	The regulation of Nrf2 KO on brain iron metabolism was likely mediated by decreasing the ferroportin 1 (FPN1) level on brain microvascular endothelial cells, thus hindering the process of iron entry into the brain.	Iron	188-192	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
33248265-7	2021	The regulation of Nrf2 KO on brain iron metabolism was likely mediated by decreasing the ferroportin 1 (FPN1) level on brain microvascular endothelial cells, thus hindering the process of iron entry into the brain.	Iron	188-192	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	89-102
33248265-7	2021	The regulation of Nrf2 KO on brain iron metabolism was likely mediated by decreasing the ferroportin 1 (FPN1) level on brain microvascular endothelial cells, thus hindering the process of iron entry into the brain.	Iron	188-192	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	104-108
33248265-8	2021	Nrf2 may be a potential therapeutic target in age-related motor dysfunction diseases for its role in regulating brain iron homeostasis.	Iron	118-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
33515478-6	2021	The results showed that the average daily feed intake (P = 0.025), average daily gain (P = 0.020), and BW (P = 0.019) increased linearly in the finishing phase of pigs fed with the diets containing Fe.	Iron	198-200	BW	Sus scrofa	103-105
33515478-7	2021	On the other hand, supplementation with different Fe levels in the diet significantly increased serum iron and transferrin saturation concentrations (P < 0.05), goblet cell numbers of duodenal villous (P < 0.001), and MUC4 mRNA expression (P < 0.05).	Iron	50-52	mucin-4	Sus scrofa	218-222
33289147-16	2021	The iron regulatory hormone, HEPC, is a link between the liver, inflammation, and iron metabolism.	Iron	4-8	hepcidin antimicrobial peptide	Rattus norvegicus	29-33
33289147-16	2021	The iron regulatory hormone, HEPC, is a link between the liver, inflammation, and iron metabolism.	Iron	82-86	hepcidin antimicrobial peptide	Rattus norvegicus	29-33
33160991-9	2021	SIGNIFICANCE: PM2.5 inhalation could exacerbate the formation and development of atherosclerosis in ApoE-/- mice, the potential mechanisms may be partly associated with iron overload via the hepcidin-FPN axis, as well as iron-triggered systemic inflammation and hyperlipidemia.	Iron	169-173	apolipoprotein E	Mus musculus	100-104
33352578-10	2021	(2) Iron was positively associated with body weight, BMI, waist-to-hip ratio, uric acid, liver enzymes, postprandial blood glucose, fasting insulin, HOMA-IR, triglycerides, free fatty acid, and hepatic steatosis (CAP value), and negatively associated with high-density lipoprotein cholesterol (all p < 0.05).	Iron	4-8	insulin	Homo sapiens	140-147
32975796-7	2021	Furthermore, we discuss a new molecular approach that can be used to understand if opioid modulation of iron affects the expression and processing of amyloid precursor protein and the contributions of this pathway to HAND.	Iron	104-108	amyloid beta precursor protein	Homo sapiens	150-175
32901916-0	2021	Arabidopsis thaliana transcription factors MYB28 AND MYB29 shape ammonium stress responses by regulating fe homeostasis.	Iron	105-107	myb domain protein 29	Arabidopsis thaliana	53-58
32901916-8	2021	Interestingly, we overall show that growing Arabidopsis with increased Fe availability relieved ammonium stress symptoms and that this was associated with MYB28 and MYB29 expression.	Iron	71-73	myb domain protein 29	Arabidopsis thaliana	165-170
33160991-0	2021	Ambient fine particulate matter aggravates atherosclerosis in apolipoprotein E knockout mice by iron overload via the hepcidin-ferroportin axis.	Iron	96-100	apolipoprotein E	Mus musculus	62-78
33532991-8	2021	CONCLUSIONS: These studies demonstrate that iron negatively regulates P-gp expression at the BBB, potentially impacting CNS drug delivery and brain beta-amyloid clearance.	Iron	44-48	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
33532991-0	2021	Increasing Intracellular Levels of Iron with Ferric Ammonium Citrate Leads to Reduced P-glycoprotein Expression in Human Immortalised Brain Microvascular Endothelial Cells.	Iron	35-39	ATP binding cassette subfamily B member 1	Homo sapiens	86-100
33457206-5	2021	The NFS1 gene encodes a cysteine desulfurase, which, in complex with ISD11 and ACP, initiates the first step of Fe-S formation.	Iron	112-116	LYR motif containing 4	Homo sapiens	69-74
33532991-2	2021	Zinc and copper are reported to modulate BBB expression and function of P-gp; however, the impact of exogenous iron, which accumulates in AD, on P-gp dynamics remains unknown.	Iron	111-115	ATP binding cassette subfamily B member 1	Homo sapiens	145-149
33532991-7	2021	While P-gp/MDR1 downregulation was associated with elevated ROS and intracellular iron, MDR1 downregulation was not attenuated with the antioxidant N-acetylcysteine nor the iron chelators desferrioxamine and deferiprone, suggesting the involvement of a ROS-independent mechanism or incomplete iron chelation.	Iron	82-86	ATP binding cassette subfamily B member 1	Homo sapiens	6-10
33532991-7	2021	While P-gp/MDR1 downregulation was associated with elevated ROS and intracellular iron, MDR1 downregulation was not attenuated with the antioxidant N-acetylcysteine nor the iron chelators desferrioxamine and deferiprone, suggesting the involvement of a ROS-independent mechanism or incomplete iron chelation.	Iron	82-86	ATP binding cassette subfamily B member 1	Homo sapiens	11-15
32696238-7	2021	On the contrary, the indices of iron metabolism (FERR, Fe, and TRSF) were positively associated with low sperm quality and sperm necrosis, particularly in leukocytospermia and varicocele groups, pathologies in which an inflammatory status and oxidative stress condition are present.	Iron	32-36	transferrin	Homo sapiens	63-67
33059156-5	2021	The reactive oxygen species produced by light or microbial metabolism could have contributed to the mineralization of poorly bioavailable OC through photochemical and biogenic Fenton processes catalyzed by the indigenous Fe in lake water.	Iron	176-178	bone gamma-carboxyglutamate protein	Homo sapiens	138-140
33212416-0	2021	Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.	Iron	69-73	heme oxygenase 1	Mus musculus	30-34
33212416-10	2021	In order to determine the effects of microglial HO-1-dependent iron overload, aged WT mice were treated with the iron chelator deferoxamine (DFX).	Iron	63-67	heme oxygenase 1	Mus musculus	48-52
33212416-12	2021	In conclusion, this study highlights how microglial HO-1 overexpression contributes to neurotoxic iron accumulation providing deleterious effects in aged mice exposed to an inflammatory insult.	Iron	98-102	heme oxygenase 1	Mus musculus	52-56
33424363-0	2021	Role of TMPRSS6 rs855791 (T > C) polymorphism in reproductive age women with iron deficiency anemia from Lahore, Pakistan.	Iron	77-81	transmembrane serine protease 6	Homo sapiens	8-15
33424363-3	2021	TMPRSS6 polymorphisms importantly rs855791 is found to play an essential role in iron homeostasis in the human body.	Iron	81-85	transmembrane serine protease 6	Homo sapiens	0-7
33520544-0	2020	Insulin Resistance and Chronic Hepatitis C: Relationship With Serum Iron and Hepcidin.	Iron	68-72	insulin	Homo sapiens	0-7
33380300-4	2021	Eltrombopag is a Thrombopoietin receptor used in thrombocytopenia, that also binds and mobilize iron.	Iron	96-100	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	17-40
33379337-9	2020	Upon iron depletion, Tif51A was down-regulated and Tif51B up-regulated.	Iron	5-9	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	51-57
33520544-10	2020	Correlation analysis indicated a negative significant correlation (rho=-0.404, p=0.036) between serum iron and insulin resistance among the diabetic CHC population.	Iron	102-106	insulin	Homo sapiens	111-118
33289738-3	2020	Herein, a new bioinspired molecular assembly strategy based on human serum albumin@polydopamine/Fe nanocomposites (HSA@PDA/Fe NCs) was proposed, in which Fe(iii)/Fe(ii) were anchored on HSA supported on PDA.	Iron	96-98	albumin	Homo sapiens	69-82
32956573-2	2020	Silylation of 1 with [(Et 3 Si) 2 (mu-H)][B(C 6 F 5 ) 4 ] leads to the ionic species [Cp*Fe(eta 5 -P 5 SiEt 3 )][B(C 6 F 5 ) 4 ] ( 2 ), whose subsequent reaction with H 2 O yields the parent compound [Cp*Fe(eta 5 -P 5 H)][B(C 6 F 5 ) 4 ] ( 3 ).	Iron	89-91	familial progressive hyperpigmentation 1	Homo sapiens	23-39
32956573-2	2020	Silylation of 1 with [(Et 3 Si) 2 (mu-H)][B(C 6 F 5 ) 4 ] leads to the ionic species [Cp*Fe(eta 5 -P 5 SiEt 3 )][B(C 6 F 5 ) 4 ] ( 2 ), whose subsequent reaction with H 2 O yields the parent compound [Cp*Fe(eta 5 -P 5 H)][B(C 6 F 5 ) 4 ] ( 3 ).	Iron	204-206	familial progressive hyperpigmentation 1	Homo sapiens	23-39
33352721-4	2020	Iron delivery is mediated via transferrin internalization by the endocytosis of transferrin receptor type 1 (TFR1), one of the most abundant membrane proteins of erythroblasts.	Iron	0-4	transferrin	Homo sapiens	30-41
33317411-1	2022	The aim of the current study was to investigate iron metabolism in endurance trained women through the interleukin-6, hepcidin and iron responses to exercise along different endogenous hormonal states.	Iron	48-52	interleukin 6	Homo sapiens	103-116
33012507-7	2020	Expression of human ZnT1 (hZnT1), in the whole body or in the entire midgut, fully rescued the dZnT1 mutant lethality, whereas tissue-specific expression of hZnT1 in the iron cell region and posterior midgut partially rescued the developmental defect of the dZnT1 mutant.	Iron	170-174	solute carrier family 30 member 1	Homo sapiens	157-162
33352696-1	2020	COASY protein-associated neurodegeneration (CoPAN) is a rare but devastating genetic autosomal recessive disorder of inborn error of CoA metabolism, which shares with pantothenate kinase-associated neurodegeneration (PKAN) similar features, such as dystonia, parkinsonian traits, cognitive impairment, axonal neuropathy, and brain iron accumulation.	Iron	331-335	Coenzyme A synthase	Homo sapiens	0-5
33380357-9	2021	After adjusting for age, sex, IL-6, and pre-existing comorbidities, all iron parameters were associated with the severity of COVID-19 with adjusted risk ratio of 0.42 [95% CI: 0.22-0.83], 4.38 [95% CI: 1.86-10.33], 0.19 [95% CI: 0.08-0.48], and 0.25 [95% CI: 0.10-0.58] for serum iron, ferritin, transferrin, and total iron-binding capacity, respectively.	Iron	72-76	interleukin 6	Homo sapiens	30-34
33007541-7	2020	Lead imposition activated iron starvation pathway via elevation in methionine content and expression of iron uptake and hemostasis-related genes including Yellow Stripe1 (ZmYS 1), S-adenosylmethionine synthase (ZmSAMS) and 2"-deoxymugineic acid synthase (ZmDMAS1) in roots.	Iron	26-30	deoxymugineic acid synthase 1	Zea mays	255-262
32881223-3	2020	By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe 3+ -promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly.	Iron	242-244	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-99
33318518-5	2020	Holo-transferrin substantially increased intracellular iron.	Iron	55-59	transferrin	Homo sapiens	5-16
32979454-9	2020	FGF2 was conjugated to superparamagnetic iron-oxide nanoparticles (SPIONs) using carbodiimide chemistry, and the resulting FGF2-SPIONs were confirmed by dynamic light scattering (DLS), zeta potential, dot-blot analysis and Prussian Blue iron-staining.	Iron	41-45	fibroblast growth factor 2	Homo sapiens	0-4
32750692-9	2020	Moreover, iron presence in crystalline structure of HA and  -TCP enhances significantly human mesenchymal stem cell metabolic activity and proliferation.	Iron	10-14	serine peptidase inhibitor Kazal type 1	Homo sapiens	61-64
32881223-3	2020	By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe 3+ -promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly.	Iron	242-244	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-99
33415156-2	2020	Indication to start iron chelation therapy is based on serum ferritin (SF) or transferrin saturation (TS) level or the amount of transfusion.	Iron	20-24	transferrin	Homo sapiens	78-89
33051210-2	2020	LukED enables S. aureus to acquire iron by lysing erythrocytes, which is dependent on targeting the host receptor Duffy antigen receptor for chemokines (DARC).	Iron	35-39	atypical chemokine receptor 1 (Duffy blood group)	Mus musculus	153-157
33321938-3	2020	Specifically, in the context of Friedreich"s ataxia (FRDA), thioredoxin family proteins may have a special role in the regulation of Nrf2 expression and function, in Fe-S cluster metabolism, controlling the expression of genes located at the iron-response element (IRE) and probably regulating ferroptosis.	Iron	166-170	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
33321938-3	2020	Specifically, in the context of Friedreich"s ataxia (FRDA), thioredoxin family proteins may have a special role in the regulation of Nrf2 expression and function, in Fe-S cluster metabolism, controlling the expression of genes located at the iron-response element (IRE) and probably regulating ferroptosis.	Iron	242-246	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
33380357-9	2021	After adjusting for age, sex, IL-6, and pre-existing comorbidities, all iron parameters were associated with the severity of COVID-19 with adjusted risk ratio of 0.42 [95% CI: 0.22-0.83], 4.38 [95% CI: 1.86-10.33], 0.19 [95% CI: 0.08-0.48], and 0.25 [95% CI: 0.10-0.58] for serum iron, ferritin, transferrin, and total iron-binding capacity, respectively.	Iron	72-76	transferrin	Homo sapiens	296-307
33302392-0	2020	Iron Therapeutics in Women"s Health: Past, Present, and Future.	Iron	0-4	EH domain containing 1	Homo sapiens	37-41
33344239-4	2020	Herein, we analyzed the effects of intravenous iron supplementation on T cell function and on the effectiveness of anti-cancer chemotherapy with IL-2/doxorubicin or immunotherapy with checkpoint-inhibitor anti-PD-L1 in C57Bl/6N female mice with implanted E0771 mammary carcinomas.	Iron	47-51	CD274 antigen	Mus musculus	210-215
33283584-10	2021	Here we synthesized a DNA carrier used surface modified iron based nanoparticles, and used it to load plasmid including ShRNA which can inhibit the expression of oncogene SLC4A4 selected by bioinformatics" method.	Iron	56-60	solute carrier family 4 member 4	Homo sapiens	171-177
33290416-0	2020	Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication.	Iron	26-30	interferon gamma	Homo sapiens	0-16
33290416-3	2020	Interferon-gamma (IFN-gamma) is a central cytokine in host defense against intracellular pathogens and has been shown to promote iron export in macrophages.	Iron	129-133	interferon gamma	Homo sapiens	0-16
33273573-10	2020	The expression level of genes involved in iron transport varied among different liver-derived cells- iron is thought to be efficiently incorporated as free Fe2+ in primary hepatocytes, whereas transferrin-iron is the main route for iron uptake in HepG2 cells.	Iron	42-46	transferrin	Homo sapiens	193-204
33242392-4	2020	We demonstrate that fSHAPE patterns predict binding sites of known RBPs, such as iron response elements in both known loci and previously unknown loci in CDC34, SLC2A4RG, COASY, and H19.	Iron	81-85	Coenzyme A synthase	Homo sapiens	171-176
33080340-0	2020	Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.	Iron	5-9	YY1 transcription factor	Mus musculus	58-61
32948607-8	2020	Mechanistically, chronic T1D leads to glucolipotoxicity inhibiting autolysosome efflux, which in turn intensifies Nrf2-driven transcription to fuel lipid peroxidation while inactivating Nrf2-mediated antioxidant defense and impairing Nrf2-coordinated iron metabolism, thereby leading to ferroptosis in cardiomyocytes.	Iron	251-255	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
32948607-8	2020	Mechanistically, chronic T1D leads to glucolipotoxicity inhibiting autolysosome efflux, which in turn intensifies Nrf2-driven transcription to fuel lipid peroxidation while inactivating Nrf2-mediated antioxidant defense and impairing Nrf2-coordinated iron metabolism, thereby leading to ferroptosis in cardiomyocytes.	Iron	251-255	nuclear factor, erythroid derived 2, like 2	Mus musculus	186-190
32948607-8	2020	Mechanistically, chronic T1D leads to glucolipotoxicity inhibiting autolysosome efflux, which in turn intensifies Nrf2-driven transcription to fuel lipid peroxidation while inactivating Nrf2-mediated antioxidant defense and impairing Nrf2-coordinated iron metabolism, thereby leading to ferroptosis in cardiomyocytes.	Iron	251-255	nuclear factor, erythroid derived 2, like 2	Mus musculus	186-190
32124228-8	2020	Iron overload groups increased serum levels of iron, transferrin saturation, and iron deposition in the liver, gastrocnemius muscle, and aorta, and the catalase was overexpressed in the aorta probably as a compensatory mechanism to the increased oxidative stress.	Iron	0-4	transferrin	Rattus norvegicus	53-64
32124228-8	2020	Iron overload groups increased serum levels of iron, transferrin saturation, and iron deposition in the liver, gastrocnemius muscle, and aorta, and the catalase was overexpressed in the aorta probably as a compensatory mechanism to the increased oxidative stress.	Iron	0-4	catalase	Rattus norvegicus	152-160
33080340-2	2020	In the present study, mice receiving a 12-months 0.3% dextran-iron diet show mild HIO with no detectable oxidative damages in the liver but have infiltrated macrophages and increased IL-6, TNFalpha, AST and ALT since 6-months.	Iron	62-66	interleukin 6	Mus musculus	183-187
33080340-2	2020	In the present study, mice receiving a 12-months 0.3% dextran-iron diet show mild HIO with no detectable oxidative damages in the liver but have infiltrated macrophages and increased IL-6, TNFalpha, AST and ALT since 6-months.	Iron	62-66	tumor necrosis factor	Mus musculus	189-197
33080340-2	2020	In the present study, mice receiving a 12-months 0.3% dextran-iron diet show mild HIO with no detectable oxidative damages in the liver but have infiltrated macrophages and increased IL-6, TNFalpha, AST and ALT since 6-months.	Iron	62-66	transmembrane protease, serine 11d	Mus musculus	199-202
32808698-5	2020	Specifically, mac1 /  mutants are profoundly deficient in mitochondrial respiration and Fe accumulation, both Cu-dependent processes.	Iron	88-90	integrin alpha M	Mus musculus	14-18
31838956-0	2020	Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients.	Iron	10-14	erythropoietin	Homo sapiens	36-39
31838956-0	2020	Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients.	Iron	10-14	erythropoietin	Homo sapiens	69-72
31838956-0	2020	Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients.	Iron	87-91	erythropoietin	Homo sapiens	69-72
31838956-1	2020	Objectives: Background/aims: We aim to explore low-risk MDS patients" ESA response and the difference between iron-overloaded (IO) group and the control group in the expression of SOCS1, STAT5 and BCL2L1 which play a key role to EPO-STAT5 signal pathway.Methods: 56 low-risk MDS patients were divided into experimental group, IO patients; control group, non-IO patients.	Iron	110-114	BCL2 like 1	Homo sapiens	197-203
32521439-9	2020	Hepcidin expression can be are upregulated after 21 days of supplementation with 150 mg of iron/ kg of diet.	Iron	91-95	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
32154642-2	2020	In hemodialysis (HD) patients, intravenous (IV) iron is associated with a greater hemoglobin (Hb) production and better erythropoietin response but may be associated to hypersensitivity reaction.	Iron	48-52	erythropoietin	Homo sapiens	120-134
31838956-5	2020	Interestingly, after receiving ICT, some patients with EPO resistance have responded again to ESA treatment, with the decrease of the expression of SOCS1, apoptotic rates of CD71+ cells, ROS expression in CD71+ cells and the increase of the expression of STAT5 and BCL2L1.Conclusion: Iron overload can increase EPO resistance and the expression of SOCS1, inhibit the expression of STAT5 and BCL2L1.	Iron	284-288	erythropoietin	Homo sapiens	55-58
32865890-0	2020	HPO iron chelator, CP655, causes the G1/S phase cell cycle block via p21 upregulation.	Iron	4-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	69-72
33148716-7	2020	In the current study, we report that interaction of the ESAT-6 protein with beta2M causes downregulation of surface HFE, a protein regulating iron homeostasis via interacting with transferrin receptor 1 (TFR1).	Iron	142-146	alpha-2-macroglobulin	Mus musculus	76-82
33148716-8	2020	We found that ESAT-6:beta2M interaction leads to sequestration of HFE in endoplasmic reticulum, causing poorer surface expression of HFE and HFE:TFR1 complex (nonfunctional TFR1) in peritoneal macrophages from C57BL/6 mice, resulting in increased holotransferrin-mediated iron uptake in these macrophages.	Iron	272-276	alpha-2-macroglobulin	Mus musculus	21-27
31295987-0	2020	BDNF pathway regulates TrkB expression in hippocampus of iron-deficient young rats.	Iron	57-61	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	23-27
32592192-1	2020	Supply of iron into human cells is achieved by iron carrier protein transferrin and its receptor, that upon complex formation get internalized by endocytosis.	Iron	10-14	transferrin	Homo sapiens	68-79
32592192-1	2020	Supply of iron into human cells is achieved by iron carrier protein transferrin and its receptor, that upon complex formation get internalized by endocytosis.	Iron	47-51	transferrin	Homo sapiens	68-79
33361849-11	2020	Transferrin wasreliably overloaded with iron: TS (70.2 +- 2.3) % compared with the control group (32.7 +- 2.1) %.	Iron	40-44	transferrin	Homo sapiens	0-11
33243156-12	2020	The need for additional iron therapy was by far the most common type of MRP.	Iron	24-28	ATP binding cassette subfamily C member 1	Homo sapiens	72-75
32976958-7	2020	Both HFD-fed mice and PA/OA-induced HepG2 cells displayed ferroptosis-based panel of biomarkers such as iron overload with the up-regulation of TFR1 and the down-regulation of FTH1, lipid peroxidation and inhibition of Nrf2 activity, which further induced GPX4 and HO-1 levels.	Iron	104-108	nuclear factor, erythroid 2	Homo sapiens	219-223
33220508-4	2021	Next, to develop a tumor-targeted contrast agent, the DHCA-Fe@Fe3O4 nanoparticles were conjugated with the F56 peptide, which targets the vascular endothelial growth factor receptor, and the resulting F56-DHCA-Fe@Fe3O4 nanoparticles were found to exhibit good T1-T2 dual-mode imaging and tumor-targeting performance both in vitro and in vivo, indicating the nanoparticles represent a new research tool for accurate tumor diagnosis.	Iron	59-61	DLEC1 cilia and flagella associated protein	Homo sapiens	107-110
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	Iron	173-177	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	Iron	173-177	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	Iron	173-177	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
33242213-4	2021	Importantly, NRF2 can reduce iron load and resist FPT.	Iron	29-33	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
32678895-7	2020	Treatment of UROS-deficient erythroid cell lines and peripheral blood CD34+-derived erythroid cultures from a CEP patient with deferiprone inhibited iron-dependent protein ALAS2 and IRP2 expression and reduced porphyrin production.	Iron	149-153	CD34 molecule	Homo sapiens	70-74
32776106-2	2020	In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the secondary carrier, ISCA1, as the direct donors of Fe-S clusters to mitochondrial NFU1, which appears to dimerize and reductively mediate formation of a bridging [4Fe-4S] cluster, aided by ferredoxin 2 (FDX2).	Iron	185-187	iron-sulfur cluster assembly enzyme	Homo sapiens	114-118
32776106-2	2020	In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the secondary carrier, ISCA1, as the direct donors of Fe-S clusters to mitochondrial NFU1, which appears to dimerize and reductively mediate formation of a bridging [4Fe-4S] cluster, aided by ferredoxin 2 (FDX2).	Iron	185-187	iron-sulfur cluster assembly enzyme	Homo sapiens	120-125
33304466-8	2020	Moreover, recent studies in the yeast Saccharomyces cerevisiae have also revealed that multiple transcription factors including Yap5 and Msn2/Msn4 contribute to the expression of CCC1 in high-iron conditions.	Iron	192-196	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	142-146
33220508-4	2021	Next, to develop a tumor-targeted contrast agent, the DHCA-Fe@Fe3O4 nanoparticles were conjugated with the F56 peptide, which targets the vascular endothelial growth factor receptor, and the resulting F56-DHCA-Fe@Fe3O4 nanoparticles were found to exhibit good T1-T2 dual-mode imaging and tumor-targeting performance both in vitro and in vivo, indicating the nanoparticles represent a new research tool for accurate tumor diagnosis.	Iron	59-61	DLEC1 cilia and flagella associated protein	Homo sapiens	201-204
33220508-4	2021	Next, to develop a tumor-targeted contrast agent, the DHCA-Fe@Fe3O4 nanoparticles were conjugated with the F56 peptide, which targets the vascular endothelial growth factor receptor, and the resulting F56-DHCA-Fe@Fe3O4 nanoparticles were found to exhibit good T1-T2 dual-mode imaging and tumor-targeting performance both in vitro and in vivo, indicating the nanoparticles represent a new research tool for accurate tumor diagnosis.	Iron	62-64	DLEC1 cilia and flagella associated protein	Homo sapiens	107-110
33220508-4	2021	Next, to develop a tumor-targeted contrast agent, the DHCA-Fe@Fe3O4 nanoparticles were conjugated with the F56 peptide, which targets the vascular endothelial growth factor receptor, and the resulting F56-DHCA-Fe@Fe3O4 nanoparticles were found to exhibit good T1-T2 dual-mode imaging and tumor-targeting performance both in vitro and in vivo, indicating the nanoparticles represent a new research tool for accurate tumor diagnosis.	Iron	62-64	DLEC1 cilia and flagella associated protein	Homo sapiens	201-204
32937103-0	2020	Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis.	Iron	37-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	9-13
33200848-8	2021	Living with paternal grandparents was protective against anemia and elevated C-reactive protein at the time of the final interview was associated with a lack of response to iron supplementation.	Iron	173-177	C-reactive protein	Homo sapiens	77-95
32937103-5	2020	Our mechanistic inquiry revealed that Nrf2 expression enhanced iron storage capacity by increasing ferritin heavy chain 1 (FTH1) expression in PC12 cells.	Iron	63-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
32937103-5	2020	Our mechanistic inquiry revealed that Nrf2 expression enhanced iron storage capacity by increasing ferritin heavy chain 1 (FTH1) expression in PC12 cells.	Iron	63-67	ferritin heavy chain 1	Rattus norvegicus	99-121
33203173-10	2020	When PA was added to the beta2m KO basal diet, a reduction (26 to 50%) of iron concentration was seen in the liver and heart.	Iron	74-78	alpha-2-macroglobulin	Mus musculus	25-31
32937103-5	2020	Our mechanistic inquiry revealed that Nrf2 expression enhanced iron storage capacity by increasing ferritin heavy chain 1 (FTH1) expression in PC12 cells.	Iron	63-67	ferritin heavy chain 1	Rattus norvegicus	123-127
32873392-5	2020	Further work demonstrated that dmfrn OE or Fer3HCH knockdown significantly rescued the impaired mitochondrial respiration in PINK1 LOF flies, indicating that dmfrn or Fer3HCH may rescue PINK1 LOF phenotypes through elevating mitochondrial bioavailable iron levels to promote mitochondrial respiration.	Iron	252-256	Ferritin 3 heavy chain homologue	Drosophila melanogaster	167-174
33187316-7	2020	These effects correlate with the ability of iron but not copper to block the induction of the antioxidant transcription factor, Nrf2, by fisetin.	Iron	44-48	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
32791852-7	2021	NRF2 was recently identified as the molecular sensor of iron-induced oxidative stress and is responsible for BMP6 expression by liver sinusoidal endothelial cells, which in turn activates hepcidin synthesis by hepatocytes to restore systemic iron levels.	Iron	242-246	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
32791852-7	2021	NRF2 was recently identified as the molecular sensor of iron-induced oxidative stress and is responsible for BMP6 expression by liver sinusoidal endothelial cells, which in turn activates hepcidin synthesis by hepatocytes to restore systemic iron levels.	Iron	242-246	bone morphogenetic protein 6	Homo sapiens	109-113
32791852-8	2021	Moreover, NRF2 orchestrates the activation of antioxidant defences that are crucial to protect against iron toxicity.	Iron	103-107	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
33205000-8	2020	When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP.	Iron	73-77	interleukin 6	Homo sapiens	205-209
33205000-8	2020	When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP.	Iron	73-77	C-reactive protein	Homo sapiens	230-233
32791852-0	2021	NRF2 and hypoxia inducible factors: key players in the redox control of systemic iron homeostasis.	Iron	81-85	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
32791852-5	2021	This review analyses the roles of key oxygen-sensing pathways in cellular and systemic regulation of iron homeostasis; specifically, the prolyl hydroxylase domain (PHD)/ hypoxia-inducible factor (HIF) and the KEAP1/NRF2 pathways, which mediate tissue adaptation to low and high oxygen, respectively.	Iron	101-105	kelch like ECH associated protein 1	Homo sapiens	209-214
32791852-5	2021	This review analyses the roles of key oxygen-sensing pathways in cellular and systemic regulation of iron homeostasis; specifically, the prolyl hydroxylase domain (PHD)/ hypoxia-inducible factor (HIF) and the KEAP1/NRF2 pathways, which mediate tissue adaptation to low and high oxygen, respectively.	Iron	101-105	NFE2 like bZIP transcription factor 2	Homo sapiens	215-219
32791852-6	2021	Recent Advances: In macrophages, NRF2 regulates genes involved in haemoglobin catabolism, iron storage, and iron export.	Iron	90-94	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
32791852-6	2021	Recent Advances: In macrophages, NRF2 regulates genes involved in haemoglobin catabolism, iron storage, and iron export.	Iron	108-112	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
32791852-7	2021	NRF2 was recently identified as the molecular sensor of iron-induced oxidative stress and is responsible for BMP6 expression by liver sinusoidal endothelial cells, which in turn activates hepcidin synthesis by hepatocytes to restore systemic iron levels.	Iron	56-60	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
33171063-0	2020	Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron.	Iron	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	36-49
33171063-6	2020	Using three human IEC cell-lines with differential basal levels of Lcn2 (i.e. HT29 < DLD-1 < Caco-2/BBe), we demonstrated that iron-free Ent could induce a dose-dependent secretion of the pro-inflammatory chemokine, interleukin 8 (IL-8), in HT29 and DLD-1 IECs, but not in Caco-2/BBe.	Iron	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	216-229
33171063-6	2020	Using three human IEC cell-lines with differential basal levels of Lcn2 (i.e. HT29 < DLD-1 < Caco-2/BBe), we demonstrated that iron-free Ent could induce a dose-dependent secretion of the pro-inflammatory chemokine, interleukin 8 (IL-8), in HT29 and DLD-1 IECs, but not in Caco-2/BBe.	Iron	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
33171063-7	2020	Ent-induced IL-8 secretion was dependent on chelation of the labile iron pool and on the levels of intracellular Lcn2.	Iron	68-72	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
33171063-8	2020	Accordingly, IL-8 secretion by Ent-treated HT29 cells could be substantially inhibited by either saturating Ent with iron or by adding exogenous Lcn2 to the cells.	Iron	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
33172142-7	2020	DFT calculations and a Monte Carlo simulation were utilized to predict the active reactivity sites of AST and calculate the lowest adsorption energy and configuration of AST alone and AST + iodide on/Fe (110)/water interface.	Iron	200-202	solute carrier family 17 member 5	Homo sapiens	170-173
33172142-7	2020	DFT calculations and a Monte Carlo simulation were utilized to predict the active reactivity sites of AST and calculate the lowest adsorption energy and configuration of AST alone and AST + iodide on/Fe (110)/water interface.	Iron	200-202	solute carrier family 17 member 5	Homo sapiens	170-173
32975364-6	2020	Deferiprone, an iron chelator, treatment resulted in the increased expression of mitochondrial ferritin (FTMT) and the localization of FTMT precursor on the mitochondrial outer membrane.	Iron	16-20	ferritin mitochondrial	Mus musculus	135-139
33048522-1	2020	The mitochondrial outer membrane protein, mitoNEET (mNT), is an iron-sulfur protein containing an Fe2S2(His)1(Cys)3 cluster with a unique single Fe-N bond.	Iron	98-100	translocase of outer mitochondrial membrane 40	Homo sapiens	4-40
33615076-7	2021	The current identification of iron deficiency in routine clinical practice is dependent on 2 surrogate markers of iron status: serum ferritin concentration and transferrin saturation (TSAT).	Iron	30-34	transferrin	Homo sapiens	160-171
33068460-4	2020	Ferroportin1 (Fpn) is the only identified nonheme iron exporter in mammals to date.	Iron	50-54	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-12
32938781-7	2020	Post-hoc analyses indicated the three-way interaction among age, Abeta, and iron content was selective to the ERC (beta = -3.34, SE = 1.33, 95%CI[-5.95, -0.72]), where a significant negative association between age and ERC volume was only present in individuals with both elevated iron content and Abeta.	Iron	76-80	amyloid beta precursor protein	Homo sapiens	298-303
33142092-5	2020	The extrinsic pathway is initiated through the regulation of transporters (e.g., inhibition of the amino acid antiporter system xc- or activation of the iron transporters transferrin and lactotransferrin), whereas the intrinsic pathway is mainly induced by blocking the expression or activity of intracellular antioxidant enzymes, such as glutathione peroxidase 4 (GPX4).	Iron	153-157	lactotransferrin	Homo sapiens	187-203
33068460-4	2020	Ferroportin1 (Fpn) is the only identified nonheme iron exporter in mammals to date.	Iron	50-54	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	14-17
33068460-6	2020	Fpn deficiency induced by injecting an adeno-associated virus (AAV) overexpressing cre recombinase into aged Fpn-floxed mice significantly worsened the symptoms post-ICH, including hematoma volume, cell apoptosis, iron accumulation, and neurologic dysfunction.	Iron	214-218	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-3
33068460-12	2020	Our study demonstrated the critical role of miR-124/Fpn signaling in iron metabolism and neuronal death post-ICH in aged murine model.	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	52-55
32918595-9	2020	These results demonstrate that a high percentage of CDA-I patients have liver iron concentration above the normal values, risking them with significant morbidity and mortality, and emphasize the importance of periodic MRI T2* studies for direct assessment of tissue iron concentration in these patients, taking age and transfusional burden into consideration.	Iron	78-82	codanin 1	Homo sapiens	52-57
32918595-0	2020	Hepatic and cardiac iron load as determined by MRI T2* in patients with congenital dyserythropoietic anemia type I.	Iron	20-24	codanin 1	Homo sapiens	72-114
32918595-9	2020	These results demonstrate that a high percentage of CDA-I patients have liver iron concentration above the normal values, risking them with significant morbidity and mortality, and emphasize the importance of periodic MRI T2* studies for direct assessment of tissue iron concentration in these patients, taking age and transfusional burden into consideration.	Iron	266-270	codanin 1	Homo sapiens	52-57
32918595-1	2020	Iron overload comprises one of the main complications of congenital dyserythropoietic anemia type I (CDA-I).	Iron	0-4	codanin 1	Homo sapiens	57-99
32918595-1	2020	Iron overload comprises one of the main complications of congenital dyserythropoietic anemia type I (CDA-I).	Iron	0-4	codanin 1	Homo sapiens	101-106
33850616-1	2020	Introduction: Hepcidin is the main modulator of systemic iron metabolism, and its role in the brain has been clarified recently.	Iron	57-61	hepcidin antimicrobial peptide	Rattus norvegicus	14-22
32679248-3	2020	PCBP1 is involved in the iron storage pathway that involves ferritin, while PCBP2 is involved in processes that include: iron transfer from the iron importer, divalent metal ion transporter 1; iron export mediated by ferroportin-1; and heme degradation via heme oxygenase 1.	Iron	25-29	poly(rC) binding protein 1	Homo sapiens	0-5
32679248-3	2020	PCBP1 is involved in the iron storage pathway that involves ferritin, while PCBP2 is involved in processes that include: iron transfer from the iron importer, divalent metal ion transporter 1; iron export mediated by ferroportin-1; and heme degradation via heme oxygenase 1.	Iron	121-125	poly(rC) binding protein 2	Homo sapiens	76-81
32679248-3	2020	PCBP1 is involved in the iron storage pathway that involves ferritin, while PCBP2 is involved in processes that include: iron transfer from the iron importer, divalent metal ion transporter 1; iron export mediated by ferroportin-1; and heme degradation via heme oxygenase 1.	Iron	121-125	poly(rC) binding protein 2	Homo sapiens	76-81
32679248-3	2020	PCBP1 is involved in the iron storage pathway that involves ferritin, while PCBP2 is involved in processes that include: iron transfer from the iron importer, divalent metal ion transporter 1; iron export mediated by ferroportin-1; and heme degradation via heme oxygenase 1.	Iron	121-125	poly(rC) binding protein 2	Homo sapiens	76-81
32679248-4	2020	MAJOR CONCLUSIONS: Both PCBP1 and PCBP2 possess iron-binding activity and form hetero/homo dimer complexes.	Iron	48-52	poly(rC) binding protein 1	Homo sapiens	24-29
32679248-4	2020	MAJOR CONCLUSIONS: Both PCBP1 and PCBP2 possess iron-binding activity and form hetero/homo dimer complexes.	Iron	48-52	poly(rC) binding protein 2	Homo sapiens	34-39
33850616-2	2020	Studies have shown that hepcidin plays an important role in neuronal iron load and inflammation.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	24-32
32712481-6	2020	Most of these Fe rich particles are inhalable (PM2.5), as determined by the anhysteretic ratio chiARM/chi (0.1-1 mum) and scanning electron microscopy (<1 mum), and host a variety of potentially toxic elements (Cr, Mo, Ni, and V).	Iron	14-16	latexin	Homo sapiens	113-116
32682801-2	2020	We identified an area of test ordering confusion with iron studies that involves total iron binding capacity (TIBC), transferrin, and transferrin saturation.	Iron	54-58	transferrin	Homo sapiens	117-128
32682801-2	2020	We identified an area of test ordering confusion with iron studies that involves total iron binding capacity (TIBC), transferrin, and transferrin saturation.	Iron	54-58	transferrin	Homo sapiens	134-145
32712481-6	2020	Most of these Fe rich particles are inhalable (PM2.5), as determined by the anhysteretic ratio chiARM/chi (0.1-1 mum) and scanning electron microscopy (<1 mum), and host a variety of potentially toxic elements (Cr, Mo, Ni, and V).	Iron	14-16	latexin	Homo sapiens	155-158
32959428-5	2020	At baseline, MDS patients showing a positive response after iron chelation therapy displayed higher levels of PI-PLCbeta1/Cyclin D3/PKCalpha expression.	Iron	60-64	cyclin D3	Homo sapiens	122-131
32959428-5	2020	At baseline, MDS patients showing a positive response after iron chelation therapy displayed higher levels of PI-PLCbeta1/Cyclin D3/PKCalpha expression.	Iron	60-64	protein kinase C alpha	Homo sapiens	132-140
33037762-2	2020	BPAN is caused by variants in WD repeat domain 45(WDR45), which is characterized by iron accumulation in the basal ganglia, however, it may be atypical in early brain MRI.	Iron	84-88	WD repeat domain 45	Homo sapiens	50-55
32112499-8	2020	These changes were accompanied by upregulation of iron regulatory protein 2 (IRP-2), which led to an increase in transferrin receptor 1 (TfR-1), thus increasing iron entry into cells and potentially leading to ferroptosis.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	77-82
32571473-4	2020	In nature, iron (Fe) and Cu homeostasis are often linked and it can be envisioned that paa1 acclimates its photosynthetic machinery by adjusting expression of its chloroplast Fe-proteome, but outside of Cu homeostasis paa1 has not been studied.	Iron	11-15	proteasome alpha subunit A1	Arabidopsis thaliana	87-91
32571473-4	2020	In nature, iron (Fe) and Cu homeostasis are often linked and it can be envisioned that paa1 acclimates its photosynthetic machinery by adjusting expression of its chloroplast Fe-proteome, but outside of Cu homeostasis paa1 has not been studied.	Iron	17-19	proteasome alpha subunit A1	Arabidopsis thaliana	87-91
32571473-8	2020	The regulation of Fe-related photosynthetic electron transport proteins in response to Fe status was maintained in paa1, suggesting that regulation of the chloroplast Fe proteins ignores operational signals from photosynthetic output.	Iron	18-20	proteasome alpha subunit A1	Arabidopsis thaliana	115-119
32571473-8	2020	The regulation of Fe-related photosynthetic electron transport proteins in response to Fe status was maintained in paa1, suggesting that regulation of the chloroplast Fe proteins ignores operational signals from photosynthetic output.	Iron	87-89	proteasome alpha subunit A1	Arabidopsis thaliana	115-119
33047775-9	2020	In promoters of differentially expressed genes, binding motifs for AP2/ERF transcription factors were most abundant and three AP2/ERF transcription factors were also differentially expressed early after low Fe treatment.	Iron	207-209	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	67-70
33047775-9	2020	In promoters of differentially expressed genes, binding motifs for AP2/ERF transcription factors were most abundant and three AP2/ERF transcription factors were also differentially expressed early after low Fe treatment.	Iron	207-209	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	126-129
32906022-7	2020	The FCR (ferric chelate reductase) activity in root along with the Fe concentration in root and shoot significantly increased, being consistent with the upregulation of Fe-related genes (SlNramp1 and SlFRO1) in roots.	Iron	169-171	root-specific metal transporter	Solanum lycopersicum	187-195
33565438-1	2020	The evaluation of iron status in dialysis patients provides information essential to the planning of adequate recombinant human erythropoietin treatment.	Iron	18-22	erythropoietin	Homo sapiens	128-142
33143139-4	2020	During infection, the host iron is bound to proteins such as transferrin, ferritin, and haemoglobin.	Iron	27-31	transferrin	Homo sapiens	61-72
32949958-0	2020	Altered homodimer formation and increased iron accumulation in VAC14-related disease: Case report and review of the literature.	Iron	42-46	VAC14 component of PIKFYVE complex	Homo sapiens	63-68
32492604-5	2020	Ultimately, lysosomal iron mediated lysosomal-mitochondrial apoptosis increased the postmortem bovine muscle desmin and troponin-T degradation (P < 0.05).	Iron	22-26	desmin	Bos taurus	109-115
32945658-6	2020	The interactions inhibiting heme dissociation were then seen to be (i) either a direct or a water molecule mediated interaction between distal histidine and heme iron; and (ii) stacking between heme and the alphaCE1/betaCD1 phenylalanine residue.	Iron	162-166	angiotensin I converting enzyme	Homo sapiens	207-223
33145027-13	2020	In addition, treatment of RPE cells with peroxisome proliferator-activated receptor (PPAR) alpha-agonist fenofibrate prevented iron-induced activation of oxidative stress and Wnt/beta-catenin signaling by chelating the iron.	Iron	127-131	peroxisome proliferator activated receptor alpha	Mus musculus	41-96
33145027-13	2020	In addition, treatment of RPE cells with peroxisome proliferator-activated receptor (PPAR) alpha-agonist fenofibrate prevented iron-induced activation of oxidative stress and Wnt/beta-catenin signaling by chelating the iron.	Iron	219-223	peroxisome proliferator activated receptor alpha	Mus musculus	41-96
33116116-6	2020	The iron-suppressive effect was mainly mediated by inducing an increase in the expression of the iron exporter ferroportin-1.	Iron	4-8	solute carrier family 40 member 1	Rattus norvegicus	111-124
33116116-6	2020	The iron-suppressive effect was mainly mediated by inducing an increase in the expression of the iron exporter ferroportin-1.	Iron	97-101	solute carrier family 40 member 1	Rattus norvegicus	111-124
33178327-7	2020	Serum hepcidin level was determined to evaluate iron homeostasis.	Iron	48-52	hepcidin antimicrobial peptide	Rattus norvegicus	6-14
33145420-7	2020	Our results lead to a new hypothesis that human iron transport is regulated as the paired transfer of iron from ferroportin to Cp to transferrin, and the tyrosine residue in Cp acts as a gate to avoid reactive oxygen species (ROS) formation when Fe2+ delivery is dysregulated.	Iron	48-52	transferrin	Homo sapiens	133-144
33145420-7	2020	Our results lead to a new hypothesis that human iron transport is regulated as the paired transfer of iron from ferroportin to Cp to transferrin, and the tyrosine residue in Cp acts as a gate to avoid reactive oxygen species (ROS) formation when Fe2+ delivery is dysregulated.	Iron	102-106	transferrin	Homo sapiens	133-144
33193643-9	2020	The patients were homozygous for the rs855791 variant of the TMPRSS6 gene which has earlier been shown to down-regulate iron absorption and accumulation.	Iron	120-124	transmembrane serine protease 6	Homo sapiens	61-68
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	10-14	transferrin	Homo sapiens	22-33
33121166-7	2020	Additionally, iron stimulated the activation of the NFkappaB pathway, and the activation was associated with iron-induced migration and MMP-2/-9 expression in 12Z cells.	Iron	14-18	nuclear factor kappa B subunit 1	Homo sapiens	52-60
33121166-7	2020	Additionally, iron stimulated the activation of the NFkappaB pathway, and the activation was associated with iron-induced migration and MMP-2/-9 expression in 12Z cells.	Iron	109-113	nuclear factor kappa B subunit 1	Homo sapiens	52-60
33121166-9	2020	Taken together, these results suggest that iron may contribute to the migration abilities of human endometriotic cells via MMP expression through the ROS-NFkappaB pathway.	Iron	43-47	nuclear factor kappa B subunit 1	Homo sapiens	154-162
33195696-6	2020	Results: The results demonstrated that iron status had a significant causal effect on VVs of lower extremities (P < 0.001) and a potential effect on coronary atherosclerosis (P < 0.05 for serum iron, ferritin, and transferrin saturation, respectively), but not on other VDs.	Iron	39-43	transferrin	Homo sapiens	214-225
33195696-7	2020	Furthermore, higher iron status exerted a detrimental effect on VVs of lower extremities in both genders (P < 0.05) and a protective effect on male patients with coronary atherosclerosis (P < 0.05 for serum iron, ferritin, and transferrin saturation, respectively).	Iron	20-24	transferrin	Homo sapiens	227-238
33107260-6	2020	Bone mineral density (BMD) of iron accumulation group (0.167+-0.024) g / cm3 was lower than control group(0.400+-0.030)g / cm3.	Iron	30-34	Cardiac mass QTL 3	Rattus norvegicus	73-76
33107260-6	2020	Bone mineral density (BMD) of iron accumulation group (0.167+-0.024) g / cm3 was lower than control group(0.400+-0.030)g / cm3.	Iron	30-34	Cardiac mass QTL 3	Rattus norvegicus	123-126
33113362-3	2020	Further, we demonstrate that erythrophagocytosis by macrophages, including a skin-residing CD163+CD91+ professional iron-recycling subpopulation, produces HO-1 after bites.	Iron	116-120	heme oxygenase 1	Mus musculus	155-159
33108526-4	2020	It is found that the brittle-ductile transition from brittle regions to ductile regions with the transition metal elements Fe and Ru in L10-TiAl and B2-TiAl at the low concentration is approximately from 0 to 6.25 at.%.	Iron	123-125	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	136-139
33108526-7	2020	Furthermore, the L10-TiAl and B2-TiAl at low concentration of Fe and Ru can increase the value of ELF, where Ge and Sn atoms become bigger at a high concentration in L10-TiAl and B2-TiAl.	Iron	62-64	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	17-20
33108526-7	2020	Furthermore, the L10-TiAl and B2-TiAl at low concentration of Fe and Ru can increase the value of ELF, where Ge and Sn atoms become bigger at a high concentration in L10-TiAl and B2-TiAl.	Iron	62-64	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	166-169
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	135-139	transferrin	Homo sapiens	22-33
33096618-3	2020	Serum iron and glucose levels are subjected to hormonal regulation by hepcidin and insulin, respectively.	Iron	6-10	insulin	Homo sapiens	83-90
33114262-3	2020	In the case of iron(III) and H3salmp, when using NaOH as a base instead of NEt3, the dinuclear complexes [Fe2(mu-salmp)(mu-OR)(salim)2], R = Me, H (2b,c) could be isolated and spectroscopically characterized, including the crystal structure of 2b 1.5H2O, which showed that rupture of one salmp3- to two coordinated salim- ligands and release of one salH molecule occurred.	Iron	15-19	h (2b,c	None	145-152
32811647-5	2020	Mass spectrometry analysis further showed that lactotransferrin (LTF), an iron-binding transport protein, is a direct NEDD4L-binding protein.	Iron	74-78	lactotransferrin	Homo sapiens	47-63
32811647-5	2020	Mass spectrometry analysis further showed that lactotransferrin (LTF), an iron-binding transport protein, is a direct NEDD4L-binding protein.	Iron	74-78	lactotransferrin	Homo sapiens	65-68
32811647-6	2020	Consequently, NEDD4L-mediated LTF protein degradation inhibits intracellular iron accumulation and subsequent oxidative damage-mediated ferroptotic cell death in various cancer cells.	Iron	77-81	lactotransferrin	Homo sapiens	30-33
33096672-6	2020	In particular, by using in vivo and in vitro models of fasting, we found that typical Nrf2-dependent genes, including those controlling iron (e.g., Ho-1) and glutathione (GSH) metabolism (e.g., Gcl, Gsr) are induced along with increased levels of the glutathione peroxidase 4 (Gpx4), a GSH-dependent antioxidant enzyme.	Iron	136-140	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
33192567-11	2020	Conversely, serum TIMP-1 levels inversely correlated with serum iron levels.	Iron	64-68	TIMP metallopeptidase inhibitor 1	Homo sapiens	18-24
33092142-5	2020	In neonates lacking HO1, functioning of renal molecular machinery responsible for iron reabsorption from the primary urine (megalin/cubilin complex) and its transfer to the blood (ferroportin) was either shifted in time or impaired, respectively.	Iron	82-86	heme oxygenase 1	Mus musculus	20-23
32960642-4	2020	Due to poor hemoglobin response with repleted iron deposits, recombinant human erythropoietin was associated.	Iron	46-50	erythropoietin	Homo sapiens	79-93
32960642-7	2020	In patients with inadequate response to intravenous iron, treatment with recombinant human erythropoietin may be considered, although its use in pregnant women without chronic renal failure has no indication in the prescribing information of this drug.	Iron	52-56	erythropoietin	Homo sapiens	91-105
33092142-7	2020	We postulate that, as a consequence of these abnormalities, a tight systemic iron balance of HO1 knockout neonates may be temporarily affected.	Iron	77-81	heme oxygenase 1	Mus musculus	93-96
33060362-4	2020	57Fe Mossbauer, x-ray photoelectron, x-ray absorption, and electron-nuclear double resonance (ENDOR) spectroscopies, supported by electronic structure calculations, support a low-spin (S = 1/2) d3 Fe(V) configuration in 2 and a diamagnetic (S = 0) d2 Fe(VI) configuration in 3 Their shared seesaw geometry is electronically dictated by a balance of Fe-imido sigma- and pi-bonding interactions.	Iron	2-4	FEV transcription factor, ETS family member	Homo sapiens	197-202
32706529-4	2020	In this work, we have conjugated an A 3 AR ligand on the surface of Fe-filled CNTs with the aim to target cells overexpressing A 3 ARs.	Iron	68-70	adenosine A3 receptor	Homo sapiens	36-42
33081324-0	2020	Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells.	Iron	22-26	tumor protein p53	Homo sapiens	85-88
33081324-0	2020	Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells.	Iron	22-26	tumor protein p53	Homo sapiens	119-122
33081348-2	2020	Neuropathological lesions of AD are neurofibrillary tangles (NFTs), and senile plaques comprise the accumulated amyloid-beta (Abeta), loaded with metal ions including Cu, Fe, or Zn.	Iron	171-173	amyloid beta precursor protein	Homo sapiens	112-124
32782144-9	2020	We suggest that low iron availability attenuates BCAA- and insulin-stimulated protein synthesis, possibly via activation of AMPK in myotubes.	Iron	20-24	insulin	Homo sapiens	59-66
33240780-6	2020	The three-phase Au/o-CFP electrocatalyst presents an excellent NRR performance with high NH3 yield rate of 40.6 microg h-1 mg-1 at -0.30 V and great FE of 31.3% at -0.10 V versus RHE (0.1 m Na2SO4).	Iron	149-151	complement factor properdin	Homo sapiens	21-24
32535472-2	2020	In pure CFA solution, the CFA degradation rate was accelerated with an increase in oxidant dosage and 2.15 mg L-1 (0.01 mM) CFA could be completed removed within 30 min with 270 mg L-1 (1 mM) potassium persulfate (PS) activated by 56 mg L-1 iron powder (Fe).	Iron	241-245	L1 cell adhesion molecule	Homo sapiens	110-113
32535472-2	2020	In pure CFA solution, the CFA degradation rate was accelerated with an increase in oxidant dosage and 2.15 mg L-1 (0.01 mM) CFA could be completed removed within 30 min with 270 mg L-1 (1 mM) potassium persulfate (PS) activated by 56 mg L-1 iron powder (Fe).	Iron	254-256	L1 cell adhesion molecule	Homo sapiens	110-113
32965100-2	2020	The strength of magnetic interfacial coupling is determined as the function of temperature and reaches up 0.194 erg/cm2 at 200 K. Meanwhile, the Gilbert damping of Fe layer is enhanced from 0.035 of 300 K to 0.050 of 200 K. The enhancement is linearly proportional to the strength of magnetic interfacial coupling.	Iron	164-166	ETS transcription factor ERG	Homo sapiens	112-115
32512057-6	2020	METHODS: We retrospectively assessed 32 CDA1 patients (median age 17.5, range 6-61) that underwent routine assessment of iron overload by cardiac magnetic resonance.	Iron	121-125	codanin 1	Homo sapiens	40-44
33043782-1	2020	Aim: Pantothenate kinase associated neurodegeneration (PKAN) is a severe autosomal recessive rare disease and characterized by iron accumulation in the basal ganglia.	Iron	127-131	pantothenate kinase 2	Homo sapiens	5-53
33043782-1	2020	Aim: Pantothenate kinase associated neurodegeneration (PKAN) is a severe autosomal recessive rare disease and characterized by iron accumulation in the basal ganglia.	Iron	127-131	pantothenate kinase 2	Homo sapiens	55-59
32805002-3	2020	OBJECTIVES: We investigated ways to increase iron absorption from FeSO4-fortified tef injera in normal-weight healthy women (aged 21-29 y).	Iron	45-49	TEF transcription factor, PAR bZIP family member	Homo sapiens	82-85
32805002-14	2020	Replacing 10% tef with whole wheat flour during injera fermentation tripled FIA in young women and should be considered as a potential strategy to improve iron status in Ethiopia.	Iron	155-159	TEF transcription factor, PAR bZIP family member	Homo sapiens	14-17
33240780-8	2020	Significantly, the three-phase Au/o-CFP exhibits excellent stability with a negligible fluctuation of NH3 yield and FE in seven-cycle test.	Iron	116-118	complement factor properdin	Homo sapiens	36-39
33028849-1	2020	ACO2 is a mitochondrial protein, which is critically involved in the function of the tricarboxylic acid cycle (TCA), the maintenance of iron homeostasis, oxidative stress defense and the integrity of mitochondrial DNA (mtDNA).	Iron	136-140	aconitase 2	Homo sapiens	0-4
31848921-7	2020	Meanwhile, the increased divalent metal transporter 1 (DMT1) expression enhanced iron import and the decreased ferroportin 1 (Fpn1) expression reduced iron export in AlCl3-exposed groups.	Iron	151-155	solute carrier family 40 member 1	Rattus norvegicus	111-124
33054130-0	2021	The <i>TMPRSS6</i> variant (SNP rs855791) affects iron metabolism and oral iron absorption - a stable iron isotope study in Taiwanese women.	Iron	50-54	transmembrane serine protease 6	Homo sapiens	7-14
33054130-0	2021	The <i>TMPRSS6</i> variant (SNP rs855791) affects iron metabolism and oral iron absorption - a stable iron isotope study in Taiwanese women.	Iron	75-79	transmembrane serine protease 6	Homo sapiens	7-14
33054130-0	2021	The <i>TMPRSS6</i> variant (SNP rs855791) affects iron metabolism and oral iron absorption - a stable iron isotope study in Taiwanese women.	Iron	75-79	transmembrane serine protease 6	Homo sapiens	7-14
33054130-1	2021	Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin.	Iron	69-73	transmembrane serine protease 6	Homo sapiens	36-43
32434157-9	2020	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.	Iron	226-228	albumin	Homo sapiens	30-43
32692954-6	2020	Herein it is shown that bHLH121 is necessary for the expression of the main markers of the plant responses to Fe excess, the ferritin genes (i.e. FER1, FER3, and FER4).	Iron	110-112	ferretin 1	Arabidopsis thaliana	146-150
32692954-6	2020	Herein it is shown that bHLH121 is necessary for the expression of the main markers of the plant responses to Fe excess, the ferritin genes (i.e. FER1, FER3, and FER4).	Iron	110-112	ferritin 3	Arabidopsis thaliana	152-156
31880208-0	2020	ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.	Iron	35-39	autophagy related 7	Mus musculus	0-4
31880208-3	2020	The absence of ATG7 blocked the transport of iron from ameloblasts into the maturing enamel, leading to a white instead of yellow surface of maxillary incisors.	Iron	45-49	autophagy related 7	Mus musculus	15-19
31848921-7	2020	Meanwhile, the increased divalent metal transporter 1 (DMT1) expression enhanced iron import and the decreased ferroportin 1 (Fpn1) expression reduced iron export in AlCl3-exposed groups.	Iron	151-155	solute carrier family 40 member 1	Rattus norvegicus	126-130
31848921-8	2020	The iron accumulated and ferritin heavy chains (Fth) expression decreased in all AlCl3-exposed groups led to an increase in free iron.	Iron	129-133	ferritin heavy chain 1	Rattus norvegicus	48-51
32522525-5	2020	Unexpectedly, novel di-2-pyridylketone thiosemicarbazones that demonstrate marked anti-tumor activity, down-regulate c-MET through their ability to bind intracellular iron and via mechanisms including, down-regulation of MET mRNA, enhanced lysosomal processing and increased metalloprotease-mediated cleavage.	Iron	167-171	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	117-122
32480040-0	2020	Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.	Iron	59-63	poly(rC) binding protein 1	Homo sapiens	109-114
32480040-0	2020	Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.	Iron	59-63	poly(rC) binding protein 2	Homo sapiens	121-126
32480040-0	2020	Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.	Iron	93-97	poly(rC) binding protein 1	Homo sapiens	109-114
32480040-10	2020	Poly r(C)-binding protein (PCBPs) 1 and 2 act as iron delivery chaperones to other iron-containing dioxygenases and were shown herein for the first time to be regulated by iron levels.	Iron	49-53	poly(rC) binding protein 1	Homo sapiens	6-41
32480040-10	2020	Poly r(C)-binding protein (PCBPs) 1 and 2 act as iron delivery chaperones to other iron-containing dioxygenases and were shown herein for the first time to be regulated by iron levels.	Iron	83-87	poly(rC) binding protein 1	Homo sapiens	6-41
32480040-12	2020	Confocal microscopy co-localization studies and proximity ligation assays both demonstrated decreased interaction of ADI1 with PCBP1 and PCBP2 under conditions of iron depletion using DFO.	Iron	163-167	poly(rC) binding protein 1	Homo sapiens	127-132
32480040-12	2020	Confocal microscopy co-localization studies and proximity ligation assays both demonstrated decreased interaction of ADI1 with PCBP1 and PCBP2 under conditions of iron depletion using DFO.	Iron	163-167	poly(rC) binding protein 2	Homo sapiens	137-142
32485269-4	2020	The abnormal TF trafficking in CAMKK2 hypomorphic cells correlated with a reduction in intracellular iron content and defective glucose metabolism including glycolysis and mitochondrial respiration.	Iron	101-105	transferrin	Homo sapiens	13-15
32460410-1	2020	INTRODUCTION: Ferritin regulates iron homeostasis, and is involved in the inflammation in the lung, especially in smokers; however, its associations on pulmonary function in non-smokers remain unclear.	Iron	33-37	ferritin-1, chloroplastic	Nicotiana tabacum	14-22
32565019-0	2020	Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis.	Iron	79-83	peroxisomal biogenesis factor 13	Homo sapiens	52-57
32447107-9	2020	The reactions with Fe-based nanocatalyst containing copper ions in pH = 3, initial dye concentration = 200 mg L-1, I = 3.57 mA cm-2, nanocatalyst concentration = 100 mg L-1, electrodes angular velocity = 50 rpm, Na2SO4 concentration = 0.01 M were capable of removing 97% of dye, 79% of COD and, 65% of TOC.	Iron	19-21	L1 cell adhesion molecule	Homo sapiens	110-113
32447107-9	2020	The reactions with Fe-based nanocatalyst containing copper ions in pH = 3, initial dye concentration = 200 mg L-1, I = 3.57 mA cm-2, nanocatalyst concentration = 100 mg L-1, electrodes angular velocity = 50 rpm, Na2SO4 concentration = 0.01 M were capable of removing 97% of dye, 79% of COD and, 65% of TOC.	Iron	19-21	L1 cell adhesion molecule	Homo sapiens	169-172
32828744-6	2020	The results of the current work indicated that taxifolin inhibited iron-induced apoptosis and enhanced hepatocellular survival as demonstrated by decreased activity of caspase-3 and activation of the pro-survival signaling PI3K/AKT, respectively.	Iron	67-71	caspase 3	Homo sapiens	168-177
32828744-6	2020	The results of the current work indicated that taxifolin inhibited iron-induced apoptosis and enhanced hepatocellular survival as demonstrated by decreased activity of caspase-3 and activation of the pro-survival signaling PI3K/AKT, respectively.	Iron	67-71	AKT serine/threonine kinase 1	Homo sapiens	228-231
32828744-8	2020	Taxifolin mitigated the iron-induced histopathological aberration and reduced serum activity of liver enzymes (ALT and AST), highlighting enhanced liver cell integrity.	Iron	24-28	solute carrier family 17 member 5	Homo sapiens	119-122
32980004-5	2020	X-ray diffraction indicate the existing states of iron in the form of iron oxide on the TNT.	Iron	50-54	chromosome 16 open reading frame 82	Homo sapiens	88-91
32980004-6	2020	The maximum degradation efficiency (92.3%) was achieved at a hydrothermal temperature of 150  C and time of 3 h. It is found that the optimal medication of the Fe-TNT catalyst occurred at a particular combination of temperature (150  C) and reaction time (3 h), that provide the more active sites for iron to enter the crystal lattice of TNT, and that the maximum CR degradation could be achieved.	Iron	301-305	chromosome 16 open reading frame 82	Homo sapiens	163-166
32980004-6	2020	The maximum degradation efficiency (92.3%) was achieved at a hydrothermal temperature of 150  C and time of 3 h. It is found that the optimal medication of the Fe-TNT catalyst occurred at a particular combination of temperature (150  C) and reaction time (3 h), that provide the more active sites for iron to enter the crystal lattice of TNT, and that the maximum CR degradation could be achieved.	Iron	301-305	chromosome 16 open reading frame 82	Homo sapiens	338-341
32413760-6	2020	Fe, Cu and Zn were associated with biomolecules with high molecular mass compounds, such as immunoglobulins, albumin and lactoferrin whilst iodine was only found as iodide.	Iron	0-2	albumin	Homo sapiens	109-116
32741217-3	2020	Also, changes in other iron-related proteins including transferrin, ferritin, and hepcidin were observed both in the serum as well as in their mRNA expression.	Iron	23-27	transferrin	Homo sapiens	55-66
32707154-2	2020	Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1).	Iron	46-50	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	96-109
32707154-2	2020	Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1).	Iron	46-50	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	111-115
32707154-2	2020	Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1).	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	96-109
32707154-2	2020	Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1).	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	111-115
33376698-2	2020	This is as a result of iron redox reaction which generates free radicals that cause peroxidation of lipid-rich pancreas, leading to reduced insulin sensitivity.	Iron	23-27	insulin	Homo sapiens	140-147
33376698-10	2020	Conclusions: Regular blood donation may protect the body from the toxic effects of excessive iron store, which includes improved insulin sensitivity and glycemic control.	Iron	93-97	insulin	Homo sapiens	129-136
32564977-5	2020	Cellular iron metabolism is post-transcriptionally controlled by iron regulatory proteins, IRP1 and IRP2, while systemic iron balance is regulated by the iron hormone hepcidin.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	100-104
32720970-0	2020	Association between interleukin-6 gene polymorphism and iron regulation in hemodialysis patients infected with HCV.	Iron	56-60	interleukin 6	Homo sapiens	20-33
32720970-2	2020	IL-6 stimulates the release of hepcidin from the liver, suppresses intestinal iron uptake, and releases iron from internal stores.	Iron	78-82	interleukin 6	Homo sapiens	0-4
32720970-2	2020	IL-6 stimulates the release of hepcidin from the liver, suppresses intestinal iron uptake, and releases iron from internal stores.	Iron	104-108	interleukin 6	Homo sapiens	0-4
32822678-3	2020	Transferrin (Tf) is a plasma iron-binding protein that transports and delivers iron to all cells.	Iron	29-33	transferrin	Homo sapiens	0-11
32822678-3	2020	Transferrin (Tf) is a plasma iron-binding protein that transports and delivers iron to all cells.	Iron	79-83	transferrin	Homo sapiens	0-11
30894036-1	2020	BACKGROUND/AIM: Hepcidin is the main hormone in the regulation of iron metabolism which is also released from the heart.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	16-24
32712297-3	2020	In the current study, we elaborate on the direct partners in calibrating the capability of FPN in exporting iron out of cells, such as ceruloplasmin (CP), hephaestin (HP) and poly(rC)-binding protein 2 (PCBP2).	Iron	108-112	poly(rC) binding protein 2	Homo sapiens	203-208
32620237-4	2020	The presence of free iron in the form of non-transferrin bound iron (NTBI) is especially detrimental.	Iron	21-25	transferrin	Homo sapiens	45-56
32793311-8	2020	Furthermore, erastin-induced breast cancer cell death was inhibited by an iron chelator, deferoxamine, which inhibited the increases of erastin-induced iron levels and inhibited the erastin-induced changes in the expression levels of the autophagy-related proteins beclin1, ATG5, ATG12, LC3B and P62.	Iron	74-78	autophagy related 5	Homo sapiens	274-278
31869431-7	2020	Overexpression of iron regulatory genes was also detected in patients with TSC, FCD IIb and Tsc1GFAP-/- mice.	Iron	18-22	TSC complex subunit 1	Homo sapiens	75-78
31869431-8	2020	CONCLUSION: Our results demonstrate that early and sustained activation of anti-oxidant signalling and dysregulation of iron metabolism are a pathological hallmark of FCD IIb and TSC.	Iron	120-124	TSC complex subunit 1	Homo sapiens	179-182
32959272-4	2020	By performing RNA sequencing analysis, we found that the main iron storage protein ferritin heavy chain 1 (FTH1) is differentially expressed in the rat 6-hydroyxdopamine (6-OHDA) model of PD compared with control rats.	Iron	62-66	ferritin heavy chain 1	Rattus norvegicus	83-105
32959272-4	2020	By performing RNA sequencing analysis, we found that the main iron storage protein ferritin heavy chain 1 (FTH1) is differentially expressed in the rat 6-hydroyxdopamine (6-OHDA) model of PD compared with control rats.	Iron	62-66	ferritin heavy chain 1	Rattus norvegicus	107-111
32959272-5	2020	Our present work demonstrates that FTH1 is involved in iron accumulation and the ferroptosis pathway in this model.	Iron	55-59	ferritin heavy chain 1	Rattus norvegicus	35-39
32793311-8	2020	Furthermore, erastin-induced breast cancer cell death was inhibited by an iron chelator, deferoxamine, which inhibited the increases of erastin-induced iron levels and inhibited the erastin-induced changes in the expression levels of the autophagy-related proteins beclin1, ATG5, ATG12, LC3B and P62.	Iron	74-78	autophagy related 12	Homo sapiens	280-285
33083244-9	2020	Increased iron at transplant was associated with higher serum iron and transferrin saturation at biopsy, and with lower hemoglobin level, greater mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, higher ferritin and model for end-stage liver disease score at transplant.	Iron	10-14	transferrin	Homo sapiens	71-82
32841843-5	2020	"Iron overload risk" was defined as transferrin saturation (TSAT) > 45% on two consecutive follow-up visits.	Iron	1-5	transferrin	Homo sapiens	36-47
32812623-4	2020	This constructed transferrin modified gadolinium-iron chelate nanoprobe, named as TUG, shows high biocompatibility within a given dose range.	Iron	49-53	transferrin	Homo sapiens	17-28
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	NAD(P)H quinone dehydrogenase 1	Homo sapiens	227-231
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	glutamate-cysteine ligase modifier subunit	Homo sapiens	233-237
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	toll like receptor 6	Homo sapiens	328-332
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	DEAD-box helicase 24	Homo sapiens	346-351
33133111-0	2020	Dissection of Root Transcriptional Responses to Low pH, Aluminum Toxicity and Iron Excess Under Pi-Limiting Conditions in Arabidopsis Wild-Type and stop1 Seedlings.	Iron	78-82	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	148-153
33133111-7	2020	Using RNA-seq, we performed a transcriptional dissection of wild-type and stop1 root responses, individually or in combination, to toxic levels of Al3+, low Pi availability, low pH and Fe excess.	Iron	185-187	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	74-79
33133111-10	2020	Our data indicate that perception of low Pi availability, low pH, Fe excess and Al toxicity converges at two levels via STOP1 signaling: post-translationally through the regulation of STOP1 turnover, and transcriptionally, via the activation of STOP1-dependent gene expression that enables the root to better adapt to abiotic stress factors present in acidic soils.	Iron	66-68	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	120-125
33133111-10	2020	Our data indicate that perception of low Pi availability, low pH, Fe excess and Al toxicity converges at two levels via STOP1 signaling: post-translationally through the regulation of STOP1 turnover, and transcriptionally, via the activation of STOP1-dependent gene expression that enables the root to better adapt to abiotic stress factors present in acidic soils.	Iron	66-68	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	184-189
33133111-10	2020	Our data indicate that perception of low Pi availability, low pH, Fe excess and Al toxicity converges at two levels via STOP1 signaling: post-translationally through the regulation of STOP1 turnover, and transcriptionally, via the activation of STOP1-dependent gene expression that enables the root to better adapt to abiotic stress factors present in acidic soils.	Iron	66-68	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	184-189
32971361-6	2020	However, Fe-S clusters associated with the CPC motif are essential to facilitate the two-electron to one-electron transfer for reducing cytochrome C.	Iron	9-13	cytochrome c, somatic	Homo sapiens	136-148
31872339-6	2020	In animal experiments, we found that FeTmPyP, a representative ONOO- decomposition catalyst (PDC), significantly reduced the expression of HMGB1 and its receptor TLR2, and inhibited MMP-9 activation, preserved collagen IV and tight junction claudin-5 in ischemic rat brains with delayed t-PA treatment.	Iron	37-44	toll-like receptor 2	Rattus norvegicus	162-166
33061378-10	2020	The transfected cells showed higher intracellular iron accumulation and resulted in a lower MR T2-weighted imaging (T2WI) intensity, suggesting that the transfection of AFP@Fth could be a potential strategy for early diagnosis of liver cancer.	Iron	50-54	alpha fetoprotein	Homo sapiens	169-172
33062715-2	2020	The insulin-resistant state causes iron overload in neurons and leads to lesions in the central nervous system.	Iron	35-39	insulin	Homo sapiens	4-11
32974685-3	2020	It is derived from Sin + 1(and/or Si-n + 1) clusters by replacing a silicon atom with an iron atom.	Iron	89-93	MAPK associated protein 1	Homo sapiens	19-26
32959848-0	2020	Effect of albumin on the transformation of dinitrosyl iron complexes with thiourea ligands.	Iron	54-58	albumin	Homo sapiens	10-17
33029199-0	2020	Efficacy of iron supplementation in patients with inflammatory bowel disease treated with anti-tumor necrosis factor-alpha agents.	Iron	12-16	tumor necrosis factor	Homo sapiens	95-122
33029199-3	2020	We assessed the effect of iron supplementation in patients with IBD initially treated with an anti-TNF-alpha agent.	Iron	26-30	tumor necrosis factor	Homo sapiens	99-108
33029199-8	2020	In a subgroup analysis of severely anemic patients with IBD, iron supplementation increased the magnitude of the improvement in Hb level (8.5 +- 1.5-11.4 +- 2.1 g/dL; p = 0.001) compared with the anti-TNF-alpha group (9.3 +- 0.8-11.4 +- 2.7 g/dL; p = 0.081).	Iron	61-65	tumor necrosis factor	Homo sapiens	201-210
33029199-11	2020	Conclusion: In anemic patients with IBD, anti-TNF-alpha agents led to clinically meaningful improvements in anemia independent of iron supplementation.	Iron	130-134	tumor necrosis factor	Homo sapiens	46-55
32766655-1	2020	Cell iron uptake in mammals is commonly distinguished by whether the iron is presented to the cell as transferrin-bound or not: TBI or NTBI.	Iron	5-9	transferrin	Homo sapiens	102-113
32766655-1	2020	Cell iron uptake in mammals is commonly distinguished by whether the iron is presented to the cell as transferrin-bound or not: TBI or NTBI.	Iron	69-73	transferrin	Homo sapiens	102-113
32931417-7	2020	The diagnostic accuracy of Iron-Def for identifying patients with a percentage of saturation of transferrin <15% (n=104) was 84%, with a sensitivity of 0.952 and specificity of 0.538.	Iron	27-31	transferrin	Homo sapiens	96-107
32944219-8	2020	In yeast lacking Sdo1p, the mitochondrial voltage-dependent anion channel (VDAC) Por1p is over-expressed and its deletion limits iron accumulation and increases activity of aconitase and succinate dehydrogenase.	Iron	129-133	porin POR1	Saccharomyces cerevisiae S288C	81-86
32812423-0	2020	Inhibiting NF-kappaB-Mediated Inflammation by Catechol-Type Diphenylbutadiene via an Intracellular Copper- and Iron-Dependent Pro-Oxidative Role.	Iron	111-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	11-20
32812423-5	2020	The above results support that depending on intracellular copper and iron ions, 3,4-DHB, a pro-electrophile, can be converted into its corresponding o-quinone electrophile together with the generation of ROS, a pro-oxidative event that mediates its inhibitory activity against NF-kappaB signaling and inflammation.	Iron	69-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	277-286
32917925-9	2020	The post-treatment measure of iron supply markers (i.e., Ferritin and transferrin saturation) was more frequent in patients suffering from chronic inflammatory diseases than in those without underlying chronic condition (22.6% to 41.0% vs. 3.1%; p < 0.0001).	Iron	30-34	transferrin	Homo sapiens	70-81
32984691-6	2020	So, we synthesized immunomagnetic iron nanocubes covalently conjugated with antibodies of Her2 or EGFR to capture cancer cells irrespective of the EMT status.	Iron	34-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-94
32984691-6	2020	So, we synthesized immunomagnetic iron nanocubes covalently conjugated with antibodies of Her2 or EGFR to capture cancer cells irrespective of the EMT status.	Iron	34-38	epidermal growth factor receptor	Homo sapiens	98-102
33015091-8	2020	In the older, albuminuric MRL/lpr mice, renal cortical and outer medullary non-heme iron concentrations were significantly increased compared with age-matched MRL/MpJ mice, as was the expression of the iron storage protein ferritin (P < 0.01).	Iron	84-88	Fas (TNF receptor superfamily member 6)	Mus musculus	30-33
33015091-8	2020	In the older, albuminuric MRL/lpr mice, renal cortical and outer medullary non-heme iron concentrations were significantly increased compared with age-matched MRL/MpJ mice, as was the expression of the iron storage protein ferritin (P < 0.01).	Iron	202-206	Fas (TNF receptor superfamily member 6)	Mus musculus	30-33
32942535-2	2020	In addition to loss of tumor suppressor functions, mutations in TP53 promote cancer progression by altering cellular iron acquisition and metabolism.	Iron	117-121	tumor protein p53	Homo sapiens	64-68
32942535-3	2020	A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death.	Iron	56-60	tumor protein p53	Homo sapiens	28-32
32942535-3	2020	A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death.	Iron	56-60	tumor protein p53	Homo sapiens	122-126
32942535-3	2020	A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death.	Iron	169-173	tumor protein p53	Homo sapiens	28-32
32942535-3	2020	A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death.	Iron	169-173	tumor protein p53	Homo sapiens	122-126
32942535-7	2020	As iron-mediated lipid peroxidation is critical for ferroptosis induction, we hypothesized that iron acquisition pathways would be upregulated in mutant TP53-expressing cells.	Iron	3-7	tumor protein p53	Homo sapiens	153-157
32942535-7	2020	As iron-mediated lipid peroxidation is critical for ferroptosis induction, we hypothesized that iron acquisition pathways would be upregulated in mutant TP53-expressing cells.	Iron	96-100	tumor protein p53	Homo sapiens	153-157
32930014-7	2020	Iron deficiency was defined by using two or more of these following parameters: mean corpuscular volume <100 fL, transferrin saturation <16% and serum ferritin <30 microg/L.	Iron	0-4	transferrin	Homo sapiens	113-124
33054113-0	2021	Intravenous iron preparations transiently generate non-transferrin-bound iron from two proposed pathways.	Iron	12-16	transferrin	Homo sapiens	55-66
33054113-0	2021	Intravenous iron preparations transiently generate non-transferrin-bound iron from two proposed pathways.	Iron	73-77	transferrin	Homo sapiens	55-66
32912274-11	2020	Residual ER availability (> 25% persistence in FES uptake) on day 14 was observed in 3 patients receiving 200/400 mg (3/78, 37.5%) and 1 patient receiving 400 mg (1/8, 12.5%).	Iron	47-50	estrogen receptor 1	Homo sapiens	9-11
33013818-4	2020	Upon iron deficiency, yeast utilizes two transcription factors, Aft1 and Aft2, to activate the expression of a set of genes known as the iron regulon, which are implicated in iron uptake, recycling and mobilization.	Iron	5-9	Aft2p	Saccharomyces cerevisiae S288C	73-77
33013818-4	2020	Upon iron deficiency, yeast utilizes two transcription factors, Aft1 and Aft2, to activate the expression of a set of genes known as the iron regulon, which are implicated in iron uptake, recycling and mobilization.	Iron	137-141	Aft2p	Saccharomyces cerevisiae S288C	73-77
33013818-5	2020	Moreover, Aft1 and Aft2 activate the expression of Cth2, an mRNA-binding protein that limits the expression of genes encoding for iron-containing proteins or that participate in iron-using processes.	Iron	130-134	Aft2p	Saccharomyces cerevisiae S288C	19-23
33013818-5	2020	Moreover, Aft1 and Aft2 activate the expression of Cth2, an mRNA-binding protein that limits the expression of genes encoding for iron-containing proteins or that participate in iron-using processes.	Iron	178-182	Aft2p	Saccharomyces cerevisiae S288C	19-23
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	8-12	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	47-51
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	47-51
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	47-51
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	47-51
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Iron	141-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Iron	230-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Iron	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32510613-1	2020	Transferrin-bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis.	Iron	18-22	transferrin	Homo sapiens	0-11
32510613-1	2020	Transferrin-bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis.	Iron	60-64	transferrin	Homo sapiens	0-11
32510613-12	2020	This work demonstrates a previously unappreciated common intersection in trafficking of transferrin iron and heme in the endocytic pathway of erythroid cells.	Iron	100-104	transferrin	Homo sapiens	88-99
31786754-8	2020	A significant negative correlation was observed between Delta haptoglobin concentration and Delta serum iron concentration (r = - 0.551, p = 0.027).	Iron	104-108	haptoglobin	Homo sapiens	62-73
32464486-0	2020	Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation.	Iron	74-78	bone morphogenetic protein 6	Homo sapiens	23-51
32565401-10	2020	The importance of these interactions is highlighted by the specific growth defect in iron-deficient conditions displayed by cells lacking Dhh1, Pop2, Ccr4 or Xrn1.	Iron	85-89	DExD/H-box ATP-dependent RNA helicase DHH1	Saccharomyces cerevisiae S288C	138-142
32877424-1	2020	Patients with high serum ferritin and low transferrin saturation (TSAT) levels could be considered as presenting with dysutilization of iron for erythropoiesis.	Iron	136-140	transferrin	Homo sapiens	42-53
32768957-6	2020	Furthermore, using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), we clarified that NG-R1 regulated ATP metabolism, the tricarboxylic acid (TCA) cycle, the malate-aspartate shuttle, antioxidant activity, and the homeostasis of iron and phospholipids in the striatum and hippocampus of middle cerebral artery occlusion/reperfusion (MCAO/R) rats.	Iron	263-267	reticulon 4 receptor	Rattus norvegicus	120-125
32464486-2	2020	One of these is the bone morphogenetic protein 6 (BMP6), which encodes a protein that modulates hepcidin synthesis and, consequently, iron homeostasis.	Iron	134-138	bone morphogenetic protein 6	Homo sapiens	20-48
32464486-2	2020	One of these is the bone morphogenetic protein 6 (BMP6), which encodes a protein that modulates hepcidin synthesis and, consequently, iron homeostasis.	Iron	134-138	bone morphogenetic protein 6	Homo sapiens	50-54
31978539-7	2020	We hypothesized two possible mechanisms: 1) fibroblast growth factor-23 levels are increased in parallel with serum phosphate levels and directly impair leukocyte recruitment and host defense mechanisms, and 2) circulating non-transferrin-bound iron (NTBI) is increased due to decreased iron binding capacity of the carrier protein transferrin in high-phosphate conditions.	Iron	245-249	transferrin	Homo sapiens	227-238
32981303-2	2020	Limited information is available on the association between transferrin, another marker of iron metabolism, and type 2 diabetes.	Iron	91-95	transferrin	Homo sapiens	60-71
32721044-0	2020	Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.	Iron	73-77	fibroblast growth factor 21	Homo sapiens	36-41
32348928-4	2020	The pristine MIL-88A(Fe) displayed outstanding adsorption performances towards four selected arsenic pollutants, in which the adsorption capacities toward As(III), As(V), ROX and ASA were 126.5, 164.0, 261.4 and 427.5 mg g-1, respectively.	Iron	21-23	MAX network transcriptional repressor	Homo sapiens	171-174
33054047-2	2020	The disease, transmitted as an autosomal recessive trait, is caused by mutations in the PKLR gene and is characterized by molecular and clinical heterogeneity; anemia ranges from mild or fully compensated hemolysis to life-threatening forms necessitating neonatal exchange transfusions and/or subsequent regular transfusion support; complications include gallstones, pulmonary hypertension, extramedullary hematopoiesis and iron overload.	Iron	424-428	pyruvate kinase L/R	Homo sapiens	88-92
32022258-11	2020	For example, higher dietary iron was most strongly associated with increased breast cancer risk among women with GSTT1 deletion or GSTM1/GSTT1 double deletions (pinteraction  < 0.05).	Iron	28-32	glutathione S-transferase mu 1	Homo sapiens	131-136
32077535-2	2020	NTBI can be taken up by cells expressing Zrt-, Irt-like protein-14 (ZIP14), which is regulated by iron overload and pro-inflammatory cytokines, for example, interleukin-1beta (IL-1beta) and IL-6.	Iron	98-102	interleukin 1 alpha	Rattus norvegicus	176-184
32077535-2	2020	NTBI can be taken up by cells expressing Zrt-, Irt-like protein-14 (ZIP14), which is regulated by iron overload and pro-inflammatory cytokines, for example, interleukin-1beta (IL-1beta) and IL-6.	Iron	98-102	interleukin 6	Rattus norvegicus	190-194
32077535-9	2020	In astrocyte cultures, FAC and IL-1beta stimulation increased Zip14 expression and IL-1beta stimulation increased uptake of 59 Fe.	Iron	127-129	interleukin 1 alpha	Rattus norvegicus	83-91
32962815-10	2020	These findings suggest that E2 differentially alters iron metabolism in monocytes in an IL-6 dependent manner.	Iron	53-57	interleukin 6	Homo sapiens	88-92
32962815-0	2020	Estrogen signaling differentially alters iron metabolism in monocytes in an Interleukin 6-dependent manner.	Iron	41-45	interleukin 6	Homo sapiens	76-89
32962815-2	2020	Previous work has shown that while IL-6 upregulates hepcidin synthesis and enhances iron sequestration, E2 reduces hepcidin synthesis and increases iron release.	Iron	84-88	interleukin 6	Homo sapiens	35-39
32962815-3	2020	Given that E2 upregulates IL-6 production in monocytes, it is likely that the exact effect of E2 on iron metabolism in monocytes is shaped by its effect on IL-6 expression.	Iron	100-104	interleukin 6	Homo sapiens	156-160
32754933-4	2020	have shown that the H63D variant of the homeostatic iron regulator (HFE) facilitates alpha-syn degradation via REDD1-mediated autophagy.	Iron	52-56	DNA-damage-inducible transcript 4	Mus musculus	111-116
32652260-0	2020	Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment.	Iron	0-4	interleukin 6	Homo sapiens	47-51
32652260-0	2020	Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment.	Iron	0-4	signal transducer and activator of transcription 3	Homo sapiens	57-62
32652260-0	2020	Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment.	Iron	0-4	interleukin 6	Homo sapiens	110-114
32652260-3	2020	In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells.	Iron	29-33	interleukin 6	Homo sapiens	81-94
32652260-3	2020	In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells.	Iron	29-33	interleukin 6	Homo sapiens	96-100
32652260-3	2020	In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells.	Iron	29-33	signal transducer and activator of transcription 3	Homo sapiens	141-191
32652260-3	2020	In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells.	Iron	29-33	signal transducer and activator of transcription 3	Homo sapiens	198-203
32652260-3	2020	In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells.	Iron	29-33	estrogen receptor 1	Homo sapiens	387-404
32652260-3	2020	In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells.	Iron	29-33	estrogen receptor 1	Homo sapiens	406-408
32652260-4	2020	However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility.	Iron	44-48	interleukin 6	Homo sapiens	38-42
32652260-4	2020	However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility.	Iron	44-48	interleukin 6	Homo sapiens	102-106
32652260-4	2020	However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility.	Iron	44-48	estrogen receptor 1	Homo sapiens	115-117
32652260-4	2020	However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility.	Iron	44-48	interleukin 6	Homo sapiens	102-106
32652260-4	2020	However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility.	Iron	44-48	signal transducer and activator of transcription 3	Homo sapiens	159-164
32652260-5	2020	In vivo animal studies also identified that iron overload promoted the progression of low metastatic breast cancer tumorigenicity and lung metastasis following the addition of exogenous IL-6.	Iron	44-48	interleukin 6	Homo sapiens	186-190
32652260-6	2020	This study suggested that iron overload could result in inducible IL-6 expression leading to promote malignant transformation of breast cancer cells in an paracrine or autocrine IL-6-rich inflammatory environment.	Iron	26-30	interleukin 6	Homo sapiens	66-70
32652260-6	2020	This study suggested that iron overload could result in inducible IL-6 expression leading to promote malignant transformation of breast cancer cells in an paracrine or autocrine IL-6-rich inflammatory environment.	Iron	26-30	interleukin 6	Homo sapiens	178-182
32786047-5	2020	Under iron-deficient growth conditions, SINAT1-4 were induced and ubiquitinated FREE1, thereby promoting its degradation and relieving the repressive effect of FREE1 on iron absorption.	Iron	6-10	seven in absentia of Arabidopsis 2	Arabidopsis thaliana	40-48
32786047-5	2020	Under iron-deficient growth conditions, SINAT1-4 were induced and ubiquitinated FREE1, thereby promoting its degradation and relieving the repressive effect of FREE1 on iron absorption.	Iron	169-173	seven in absentia of Arabidopsis 2	Arabidopsis thaliana	40-48
32882879-2	2020	Transferrin (TF), an endogenous iron chelator, was proposed as a therapeutic candidate.	Iron	32-36	transferrin	Rattus norvegicus	0-11
32444869-0	2020	Amyloidogenic processing of Alzheimer"s disease beta-amyloid precursor protein induces cellular iron retention.	Iron	96-100	amyloid beta precursor protein	Homo sapiens	48-78
32444869-7	2020	A new Abeta-independent hypothesis emerges where the amyloidogenic processing of APP, combined with age-dependent iron elevation in the tissue, increases pro-oxidant iron burden in AD.	Iron	114-118	amyloid beta precursor protein	Homo sapiens	6-11
32444869-7	2020	A new Abeta-independent hypothesis emerges where the amyloidogenic processing of APP, combined with age-dependent iron elevation in the tissue, increases pro-oxidant iron burden in AD.	Iron	166-170	amyloid beta precursor protein	Homo sapiens	6-11
32882879-8	2020	The neuroprotective benefits of TF non-viral gene delivery in retinal degenerative disease models further validates iron overload as a therapeutic target and supports the continued development of pEY611 for treatment of RP and dry AMD.	Iron	116-120	transferrin	Rattus norvegicus	32-34
30638054-3	2020	FE showed no cytotoxicity to human keratinocytes and an in vitro SPF of 18.56 (UV-spectrophotometry).	Iron	0-2	SEC14 like lipid binding 2	Homo sapiens	65-68
30638054-6	2020	Finally, SPF of formulation with FE was 12.45.	Iron	33-35	SEC14 like lipid binding 2	Homo sapiens	9-12
30638054-7	2020	Results from the in vitro SPF and product stability tests (especially storage under refrigeration), indicate that FE is a promising compound for use as an innovative sunscreen formulation.	Iron	114-116	SEC14 like lipid binding 2	Homo sapiens	26-29
32677046-9	2020	The three challenges with elevated iron absorption also had elevated STFR/log ferritin as well as elevated ESR and CRP, but these inflammatory markers were, in general, less elevated than those in non-absorbers.	Iron	35-39	C-reactive protein	Homo sapiens	115-118
32594838-7	2020	In addition, we verify that YSL1 and IMA1, two genes involved in signaling iron status from shoots to roots, are direct targets of H3K27me3 and reveal iron-dependent deposition of H3K27me3 on these loci.	Iron	75-79	YELLOW STRIPE like 1	Arabidopsis thaliana	28-32
32594838-7	2020	In addition, we verify that YSL1 and IMA1, two genes involved in signaling iron status from shoots to roots, are direct targets of H3K27me3 and reveal iron-dependent deposition of H3K27me3 on these loci.	Iron	151-155	YELLOW STRIPE like 1	Arabidopsis thaliana	28-32
32522963-0	2020	Involvement of Mrs3/4 in mitochondrial iron transport and metabolism in Cryptococcus neoformans.	Iron	39-43	solute carrier family 25, member 28	Mus musculus	15-21
32863216-7	2020	Importantly, mitochondrial p53 interacted with solute carrier family 25 member 28 (SLC25A28) to form complex and enhanced the activity of SLC25A28, which could lead to the abnormal accumulation of redox-active iron and hyperfunction of electron transfer chain (ETC).	Iron	210-214	tumor protein p53	Homo sapiens	27-30
32863219-0	2020	Quantitative label-free imaging of iron-bound transferrin in breast cancer cells and tumors.	Iron	35-39	transferrin	Homo sapiens	46-57
32863219-1	2020	Transferrin (Tf) is an essential serum protein which delivers iron throughout the body via transferrin-receptor (TfR)-mediated uptake and iron release in early endosomes.	Iron	62-66	transferrin	Homo sapiens	0-11
32863219-1	2020	Transferrin (Tf) is an essential serum protein which delivers iron throughout the body via transferrin-receptor (TfR)-mediated uptake and iron release in early endosomes.	Iron	138-142	transferrin	Homo sapiens	0-11
33295723-3	2020	Iron responding protein-2 (IRP2) is the protein product of IREB2 gene, which is a COPD susceptibility gene that regulates cellular iron homeostasis and has a key role in hypoxic conditions.	Iron	131-135	iron responsive element binding protein 2	Homo sapiens	0-25
33295723-3	2020	Iron responding protein-2 (IRP2) is the protein product of IREB2 gene, which is a COPD susceptibility gene that regulates cellular iron homeostasis and has a key role in hypoxic conditions.	Iron	131-135	iron responsive element binding protein 2	Homo sapiens	27-31
33295723-3	2020	Iron responding protein-2 (IRP2) is the protein product of IREB2 gene, which is a COPD susceptibility gene that regulates cellular iron homeostasis and has a key role in hypoxic conditions.	Iron	131-135	iron responsive element binding protein 2	Homo sapiens	59-64
32522963-3	2020	In this study, we identified and functionally characterized Mrs3/4, a homolog of the Saccharomyces cerevisiae mitochondrial iron transporter, in C. neoformans var.	Iron	124-128	solute carrier family 25, member 28	Mus musculus	60-66
32522963-6	2020	Moreover, a mutant lacking the MRS3/4 gene was constructed; this mutant displayed significantly reduced mitochondrial iron and cellular heme accumulation.	Iron	118-122	solute carrier family 25, member 28	Mus musculus	31-37
32522963-7	2020	In addition, impaired mitochondrial iron-sulfur cluster metabolism and altered expression of genes required for iron uptake at the plasma membrane were observed in the mrs3/4 mutant, suggesting that Mrs3/4 is involved in iron import and metabolism in the mitochondria of C. neoformans.	Iron	36-40	solute carrier family 25, member 28	Mus musculus	168-174
32438400-4	2020	We herein report the therapeutic effects of a fully human anti-BMP6 antibody (KY1070) either as monotherapy or in combination with Darbepoetin alfa on iron metabolism and anemia resolution in two different, well established and clinically relevant rodent models of ACD.	Iron	151-155	bone morphogenetic protein 6	Homo sapiens	63-67
32522963-7	2020	In addition, impaired mitochondrial iron-sulfur cluster metabolism and altered expression of genes required for iron uptake at the plasma membrane were observed in the mrs3/4 mutant, suggesting that Mrs3/4 is involved in iron import and metabolism in the mitochondria of C. neoformans.	Iron	36-40	solute carrier family 25, member 28	Mus musculus	199-205
32438400-5	2020	In addition to counteracting hepcidin driven iron limitation for erythropoiesis, we found that the combination of KY1070 and recombinant human EPO improved the erythroid response compared to either monotherapy in a qualitative and quantitative manner.	Iron	45-49	erythropoietin	Homo sapiens	143-146
32522963-7	2020	In addition, impaired mitochondrial iron-sulfur cluster metabolism and altered expression of genes required for iron uptake at the plasma membrane were observed in the mrs3/4 mutant, suggesting that Mrs3/4 is involved in iron import and metabolism in the mitochondria of C. neoformans.	Iron	112-116	solute carrier family 25, member 28	Mus musculus	168-174
32522963-7	2020	In addition, impaired mitochondrial iron-sulfur cluster metabolism and altered expression of genes required for iron uptake at the plasma membrane were observed in the mrs3/4 mutant, suggesting that Mrs3/4 is involved in iron import and metabolism in the mitochondria of C. neoformans.	Iron	112-116	solute carrier family 25, member 28	Mus musculus	199-205
32522963-9	2020	Taken together, our study suggests that Mrs3/4 is responsible for iron import in mitochondria and reveals a link between mitochondrial iron metabolism and the virulence of C. neoformans.	Iron	66-70	solute carrier family 25, member 28	Mus musculus	40-46
32522963-9	2020	Taken together, our study suggests that Mrs3/4 is responsible for iron import in mitochondria and reveals a link between mitochondrial iron metabolism and the virulence of C. neoformans.	Iron	135-139	solute carrier family 25, member 28	Mus musculus	40-46
32804006-2	2021	The iron-containing enzyme lipoxygenase is the main promoter of ferroptosis by producing lipid hydroperoxides, and its function relies on the activation of ACSL4-dependent lipid biosynthesis.	Iron	4-8	acyl-CoA synthetase long chain family member 4	Homo sapiens	156-161
32439379-2	2020	Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases.	Iron	59-63	haptoglobin	Homo sapiens	0-11
32867052-4	2020	Age-related cellular and molecular alterations in iron metabolism can also lead to iron dyshomeostasis and deposition.	Iron	50-54	renin binding protein	Homo sapiens	0-3
32867052-4	2020	Age-related cellular and molecular alterations in iron metabolism can also lead to iron dyshomeostasis and deposition.	Iron	83-87	renin binding protein	Homo sapiens	0-3
33061910-6	2020	In particular, IL-6 has been involved in mediating the effects of MIA animal models in the offspring through actions on the placenta, induction of IL-17a, or triggering the decrease in non-heme iron (hypoferremia).	Iron	194-198	interleukin 6	Homo sapiens	15-19
33414675-3	2020	It was found by Mossbauer spectra that the variation of organic ligands for synthesis have an influence on the content of Fe(II) of these MOFs, thus resulted in the order of activation capacities: Fe(Nic) > Fe(PyBDC) > Fe(PIP).	Iron	122-124	prolactin induced protein	Homo sapiens	222-225
32825437-8	2020	The adult male offspring of maternal rats fed low-iron diets before pregnancy, during pregnancy and throughout the lactation period had (1) spatial deficits, (2) a decreased BDNF mRNA expression and protein concentrations, accompanied by a decreased TrkB protein abundance, (3) a decreased plasma acetate concentration, and (4) an enrichment of the Bacteroidaceae genus Bacteroides and Lachnospiraceae genus Marvinbryantia.	Iron	50-54	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	250-254
32913554-0	2020	Targeting hepcidin improves cognitive impairment and reduces iron deposition in a diabetic rat model.	Iron	61-65	hepcidin antimicrobial peptide	Rattus norvegicus	10-18
32913554-2	2020	Hepcidin is expressed in the brain and has the ability to regulate iron.	Iron	67-71	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
32913554-13	2020	These studies demonstrate that T2DM rats developed cognitive impairment and iron deposits in the hippocampus, both of which were improved by AAV-hepcidin administration.	Iron	76-80	hepcidin antimicrobial peptide	Rattus norvegicus	145-153
32422455-9	2020	Geogenic materials (topsoil and mining tailings), and water samples could contain extremely high arsenic concentrations, i.e. 21,000 mg kg-1 or 1,700,000 mug L-1, respectively, have been found mainly at the "Iron Quadrangle".	Iron	208-212	L1 cell adhesion molecule	Homo sapiens	158-161
32621607-3	2020	We show that Bad contains an Fe-S cluster and identify four cysteine residues that are likely to co-ordinate the cluster by analogy to DNA2.	Iron	29-33	DNA replication helicase/nuclease 2	Homo sapiens	135-139
32786404-2	2020	Lactotransferrin (LTF) is a member of the family of transferrin iron binding proteins that regulate iron homeostasis, and increased levels of LTF and its receptor have been observed in neurodegenerative disorders like Parkinson"s disease.	Iron	64-68	lactotransferrin	Homo sapiens	0-16
32786404-2	2020	Lactotransferrin (LTF) is a member of the family of transferrin iron binding proteins that regulate iron homeostasis, and increased levels of LTF and its receptor have been observed in neurodegenerative disorders like Parkinson"s disease.	Iron	64-68	lactotransferrin	Homo sapiens	18-21
32786404-2	2020	Lactotransferrin (LTF) is a member of the family of transferrin iron binding proteins that regulate iron homeostasis, and increased levels of LTF and its receptor have been observed in neurodegenerative disorders like Parkinson"s disease.	Iron	100-104	lactotransferrin	Homo sapiens	0-16
32786404-2	2020	Lactotransferrin (LTF) is a member of the family of transferrin iron binding proteins that regulate iron homeostasis, and increased levels of LTF and its receptor have been observed in neurodegenerative disorders like Parkinson"s disease.	Iron	100-104	lactotransferrin	Homo sapiens	18-21
32786404-3	2020	Here, we report that Parkin binds to LTF and ubiquitylates LTF to influence iron homeostasis.	Iron	76-80	lactotransferrin	Homo sapiens	37-40
32786404-3	2020	Here, we report that Parkin binds to LTF and ubiquitylates LTF to influence iron homeostasis.	Iron	76-80	lactotransferrin	Homo sapiens	59-62
32786404-6	2020	Importantly, Parkin-mediated ubiquitylation of LTF was critical for regulating intracellular iron levels as overexpression of LTF ubiquitylation site point mutants (K649A or K182A/K649A) led to an increase in intracellular iron levels measured by ICP-MS/MS.	Iron	93-97	lactotransferrin	Homo sapiens	47-50
32786404-6	2020	Importantly, Parkin-mediated ubiquitylation of LTF was critical for regulating intracellular iron levels as overexpression of LTF ubiquitylation site point mutants (K649A or K182A/K649A) led to an increase in intracellular iron levels measured by ICP-MS/MS.	Iron	223-227	lactotransferrin	Homo sapiens	47-50
32786404-6	2020	Importantly, Parkin-mediated ubiquitylation of LTF was critical for regulating intracellular iron levels as overexpression of LTF ubiquitylation site point mutants (K649A or K182A/K649A) led to an increase in intracellular iron levels measured by ICP-MS/MS.	Iron	223-227	lactotransferrin	Homo sapiens	126-129
32786404-8	2020	Together, these results indicate that Parkin binds to and ubiquitylates LTF to regulate intracellular iron levels.	Iron	102-106	lactotransferrin	Homo sapiens	72-75
32450168-0	2020	Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice.	Iron	27-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
32450168-4	2020	This study aimed to investigate whether Nrf2 gene knockout influences iron homeostasis in aging mice.	Iron	70-74	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
32450168-6	2020	KEY FINDINGS: Results showed that the iron contents in spleen and liver all increased, and expression levels of iron transporters were altered in Nrf2-/- mice.	Iron	112-116	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	Iron	49-53	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-82
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	Iron	49-53	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	84-88
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	Iron	49-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	Iron	200-204	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-82
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	Iron	200-204	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	84-88
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	Iron	200-204	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
33414675-3	2020	It was found by Mossbauer spectra that the variation of organic ligands for synthesis have an influence on the content of Fe(II) of these MOFs, thus resulted in the order of activation capacities: Fe(Nic) > Fe(PyBDC) > Fe(PIP).	Iron	197-199	prolactin induced protein	Homo sapiens	222-225
32450168-8	2020	Surprisingly, we found that the serum iron level of Nrf2-/- mice did not decrease, but increased significantly even when the iron absorption at small intestine decreased.	Iron	38-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	52-56
32450168-8	2020	Surprisingly, we found that the serum iron level of Nrf2-/- mice did not decrease, but increased significantly even when the iron absorption at small intestine decreased.	Iron	125-129	nuclear factor, erythroid derived 2, like 2	Mus musculus	52-56
33414675-3	2020	It was found by Mossbauer spectra that the variation of organic ligands for synthesis have an influence on the content of Fe(II) of these MOFs, thus resulted in the order of activation capacities: Fe(Nic) > Fe(PyBDC) > Fe(PIP).	Iron	197-199	prolactin induced protein	Homo sapiens	222-225
32450168-9	2020	Our further investigation revealed that the increase of serum iron was due to the release of iron from the hemolysis of erythrocytes, which caused by the increased ROS level in red blood cells of the Nrf2-/- mice.	Iron	62-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	200-204
32450168-9	2020	Our further investigation revealed that the increase of serum iron was due to the release of iron from the hemolysis of erythrocytes, which caused by the increased ROS level in red blood cells of the Nrf2-/- mice.	Iron	93-97	nuclear factor, erythroid derived 2, like 2	Mus musculus	200-204
32450168-10	2020	SIGNIFICANCE: These findings provide a more comprehensive understanding of the important role of Nrf2 in the regulation of systemic iron metabolism.	Iron	132-136	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
32450779-3	2020	Both ID and CC have been demonstrated to up-regulate the level and iron-binding ability of transferrin, with our recent study showing that this up-regulation can induce hypercoagulability by potentiating FXIIa/thrombin and blocking antithrombin-coagulation proteases interactions.	Iron	67-71	transferrin	Homo sapiens	91-102
32913582-4	2020	Compared with mesophilic orthologues, the cold-adapted cytoglobins favor binding of exogenous ligands to the hexa-coordinated bis-histidyl species, a trait related to their higher rate constant for distal-His/heme-Fe dissociation relative to human cytoglobin.	Iron	214-216	cytoglobin	Homo sapiens	55-65
32790892-5	2020	Recombinant human erythropoietin (rHuEPO) with iron supplementation has frequently been used to increase preoperative haemoglobin concentrations in patients in order to avoid the need for perioperative allogeneic red blood cell (RBC) transfusion.	Iron	47-51	erythropoietin	Homo sapiens	18-32
32533954-7	2020	An iron chelator, but not an apoptosis inhibitor or a necrosis inhibitor, abolished the inhibitory effects of GNA on proliferation, invasion and migration of TGF-beta1-stimulated melanoma cells.	Iron	3-7	transforming growth factor beta 1	Homo sapiens	158-167
33013351-0	2020	Ultra-High-Resolution in vitro MRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T. Iron concentration in the brain has been suggested as a biomarker of pathologic neurodegeneration.	Iron	128-132	renin binding protein	Homo sapiens	44-47
33013351-2	2020	This study aimed to quantify the age-related changes in iron concentration in the gray matter of healthy rhesus monkeys using quantitative susceptibility mapping (QSM).	Iron	56-60	renin binding protein	Homo sapiens	33-36
32780017-3	2020	Rather, Sfh5 is a redox-active penta-coordinate high spin FeIII hemoprotein with an unusual heme-binding arrangement that involves a co-axial tyrosine/histidine coordination strategy and a complex electronic structure connecting the open shell iron d-orbitals with three aromatic ring systems.	Iron	244-248	Sfh5p	Saccharomyces cerevisiae S288C	8-12
32764239-7	2020	Furthermore, expressions of cyp7a1 and the urea cycle enzyme (ornithinetranscarbamoylase and argininosuccinate synthetase) were significantly increased in iron deficient pigs (p < 0.05).	Iron	155-159	cytochrome P450 family 7 subfamily A member 1	Sus scrofa	28-34
32788383-3	2020	We determined that H2O2-induced cytotoxicity is an iron-dependent process in HAP1 cells and conducted a CRISPR/Cas9-based survival screen that identified four genes that mediate H2O2-induced cell death: POR (encoding cytochrome P450 oxidoreductase), RETSAT (retinol saturase), KEAP1 (Kelch-like ECH-associated protein-1), and SLC52A2 (riboflavin transporter).	Iron	51-55	cytochrome p450 oxidoreductase	Homo sapiens	203-206
32518166-2	2020	Two nuclear-encoded vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been identified in mammals.	Iron	59-63	solute carrier family 25, member 37	Mus musculus	75-86
32518166-2	2020	Two nuclear-encoded vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been identified in mammals.	Iron	59-63	solute carrier family 25, member 37	Mus musculus	88-93
32518166-2	2020	Two nuclear-encoded vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been identified in mammals.	Iron	59-63	solute carrier family 25, member 28	Mus musculus	99-104
32518166-5	2020	Mfrn2 -/- mice placed on a low-iron diet exhibited reduced mitochondrial manganese, cobalt, and zinc levels, but not reduced iron.	Iron	31-35	solute carrier family 25, member 28	Mus musculus	0-5
32518166-6	2020	Hepatocyte-specific loss of Slc25a37 (encoding Mfrn1) in Mfrn2 -/- mice did not affect animal viability, but resulted in a 40% reduction in mitochondrial iron and reduced levels of oxidative phosphorylation proteins.	Iron	154-158	solute carrier family 25, member 37	Mus musculus	28-36
32518166-6	2020	Hepatocyte-specific loss of Slc25a37 (encoding Mfrn1) in Mfrn2 -/- mice did not affect animal viability, but resulted in a 40% reduction in mitochondrial iron and reduced levels of oxidative phosphorylation proteins.	Iron	154-158	solute carrier family 25, member 37	Mus musculus	47-52
32518166-7	2020	Placing animals on a low-iron diet exaggerated the reduction in mitochondrial iron observed in liver-specific Mfrn1/2-knockout animals.	Iron	25-29	solute carrier family 25, member 37	Mus musculus	110-115
32518166-7	2020	Placing animals on a low-iron diet exaggerated the reduction in mitochondrial iron observed in liver-specific Mfrn1/2-knockout animals.	Iron	78-82	solute carrier family 25, member 37	Mus musculus	110-115
32761217-0	2020	Iron turns to wild when the transferrin is away.	Iron	0-4	transferrin	Homo sapiens	28-39
32298947-7	2020	Besides, PA6/MAF (5:5) showed relatively low fire hazard reflected by the reduction of the peak of heat release rate of PA6 composite from 962 to 260 kW/m2 compared with that of pure PA6 in the cone calorimeter test, and MIL-100 (Fe) along with MCA also presented synergistic effect in suppressing the emission of carbon monoxide.	Iron	230-232	MAF bZIP transcription factor	Homo sapiens	13-16
32705819-2	2020	PKAN is associated with iron deposition in the basal ganglia and, occasionally, with the occurrence of misshaped erythrocytes (acanthocytes).	Iron	24-28	pantothenate kinase 2	Homo sapiens	0-4
32644801-8	2020	Given that Fe(IV) and Fe(V) have much greater oxidizing reactivity than Fe(VI), this work urges the development of Fe(V)/Fe(IV)-based oxidation technology for efficient degradation of TrOCs.	Iron	11-13	FEV transcription factor, ETS family member	Homo sapiens	115-120
32644801-8	2020	Given that Fe(IV) and Fe(V) have much greater oxidizing reactivity than Fe(VI), this work urges the development of Fe(V)/Fe(IV)-based oxidation technology for efficient degradation of TrOCs.	Iron	22-24	FEV transcription factor, ETS family member	Homo sapiens	115-120
32644801-8	2020	Given that Fe(IV) and Fe(V) have much greater oxidizing reactivity than Fe(VI), this work urges the development of Fe(V)/Fe(IV)-based oxidation technology for efficient degradation of TrOCs.	Iron	22-24	FEV transcription factor, ETS family member	Homo sapiens	115-120
32759740-6	2020	Treatment of stable clones of SEC23B-silenced erythroleukemia K562 cells with the iron-containing porphyrin hemin plus GDF11 increased expression of pSMAD2 and reduced nuclear localization of the transcription factor GATA1, with subsequent reduced gene expression of erythroid differentiation markers.	Iron	82-86	GATA binding protein 1	Homo sapiens	217-222
32802887-6	2020	Normally, it is predicted that STEAP1 and STEAP2 were involved in the mineral absorption process, while STEAP3 participated in the TP53 signaling pathway and iron apoptosis.	Iron	158-162	STEAP3 metalloreductase	Homo sapiens	104-110
32756361-1	2020	4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an iron-dependent non-heme oxygenase involved in the catabolic pathway of tyrosine, which is an important enzyme in the transformation of 4-hydroxyphenylpyruvic acid to homogentisic acid, and thus being considered as herbicide target.	Iron	49-53	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	0-35
32756361-1	2020	4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an iron-dependent non-heme oxygenase involved in the catabolic pathway of tyrosine, which is an important enzyme in the transformation of 4-hydroxyphenylpyruvic acid to homogentisic acid, and thus being considered as herbicide target.	Iron	49-53	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	37-41
32715763-8	2020	WT mice infused with ANG II caused increases in renal fibrosis, ROS formation, and iron contents.	Iron	83-87	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	21-27
32756017-4	2020	The energy E R of the observed spin resonance is broadly consistent with the relationship E R = 4.9k B T c, but is slightly enhanced compared to the values observed in other Fe-based superconductors.	Iron	174-176	betacellulin	Homo sapiens	101-106
32220725-8	2020	Fe showed synergistic with quinones in investigated concentration range (from 0.01 to 5 muM).	Iron	0-2	latexin	Homo sapiens	88-91
32251709-1	2020	BACKGROUND: Expression of hepcidin, a hormone produced by hepatocytes which negatively regulates the circulating iron levels, is known to be positively regulated by BMP6, a member of transforming growth factor (TGF)-beta family.	Iron	113-117	bone morphogenetic protein 6	Homo sapiens	165-169
32251709-2	2020	Previous studies have shown that iron status is sensed by sinusoidal endothelial cells of hepatic lamina, leading to the modulation of BMP6 expression.	Iron	33-37	bone morphogenetic protein 6	Homo sapiens	135-139
32251709-5	2020	RESULTS: Treatment with iron slightly increased the expression levels of Bmp6, while 2DP unexpectedly increased Bmp6 expression in a dose-dependent manner.	Iron	24-28	bone morphogenetic protein 6	Homo sapiens	73-77
32430665-8	2020	RESULTS: Iron concentration reduced, and mRNA expression of ferroportin increased, in macrophages from LysM-Cre Fth KO mice.	Iron	9-13	lysozyme 2	Mus musculus	103-107
32461519-1	2020	The direct electron transfer between human cytoglobin (Cygb) and the electrode surface, which would allow manipulating the oxidation states of the heme iron in Cygb, was first observed by immobilizing Cygb on a nanoporous gold (NPG) electrode via a carboxy-terminated alkanethiol.	Iron	152-156	cytoglobin	Homo sapiens	43-53
32461519-1	2020	The direct electron transfer between human cytoglobin (Cygb) and the electrode surface, which would allow manipulating the oxidation states of the heme iron in Cygb, was first observed by immobilizing Cygb on a nanoporous gold (NPG) electrode via a carboxy-terminated alkanethiol.	Iron	152-156	cytoglobin	Homo sapiens	55-59
32461519-1	2020	The direct electron transfer between human cytoglobin (Cygb) and the electrode surface, which would allow manipulating the oxidation states of the heme iron in Cygb, was first observed by immobilizing Cygb on a nanoporous gold (NPG) electrode via a carboxy-terminated alkanethiol.	Iron	152-156	cytoglobin	Homo sapiens	160-164
32461519-1	2020	The direct electron transfer between human cytoglobin (Cygb) and the electrode surface, which would allow manipulating the oxidation states of the heme iron in Cygb, was first observed by immobilizing Cygb on a nanoporous gold (NPG) electrode via a carboxy-terminated alkanethiol.	Iron	152-156	cytoglobin	Homo sapiens	160-164
31778583-1	2020	Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin.	Iron	69-73	bone morphogenetic protein 2	Mus musculus	28-32
32170997-7	2020	These results suggest that miR-122 agomir can prevent the accumulation of hepatic iron induced by MC-LR, which may be related to the regulation of hepcidin by BMP/SMAD and IL-6/STAT signaling pathways.	Iron	82-86	interleukin 6	Mus musculus	172-176
31778583-1	2020	Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin.	Iron	118-122	bone morphogenetic protein 2	Mus musculus	28-32
32619040-6	2020	We show that lack of ERF95 decreases abundance of FER1 mRNA in developing seed, which encodes Fe-sequestering ferritin.	Iron	94-96	ferretin 1	Arabidopsis thaliana	50-54
31778583-6	2020	Notably, dietary iron loading still induced liver SMAD5 phosphorylation and hepcidin in double Bmp6/endothelial Bmp2 KO mice, although no other BMP ligand mRNAs were increased in the livers of double KO mice, and only Bmp6 and Bmp2 mRNA were induced by dietary iron loading in wildtype mice.	Iron	17-21	bone morphogenetic protein 2	Mus musculus	112-116
31778583-6	2020	Notably, dietary iron loading still induced liver SMAD5 phosphorylation and hepcidin in double Bmp6/endothelial Bmp2 KO mice, although no other BMP ligand mRNAs were increased in the livers of double KO mice, and only Bmp6 and Bmp2 mRNA were induced by dietary iron loading in wildtype mice.	Iron	17-21	bone morphogenetic protein 2	Mus musculus	227-231
31778583-7	2020	In contrast, double Hfe/endothelial Bmp2 KO mice exhibited reduced hepcidin and increased extrahepatic iron loading compared to single Hfe or endothelial Bmp2 KO mice.	Iron	103-107	bone morphogenetic protein 2	Mus musculus	36-40
32276231-2	2020	This novel Ce-UiO-66/TNF material was proved to possess a high supercapacitive performance in the redox electrolyte of Fe(CN)63-/4-, and it was also the first study for Ce-UiO-66 material on the supercapacitor application.	Iron	119-121	tumor necrosis factor	Homo sapiens	21-24
32893763-10	2020	Lower values of transferrin and TIBC and higher TSI in colostrum from primiparous cows suggests a relationship between lower iron stock and higher antioxidant activity.	Iron	125-129	serotransferrin	Bos taurus	16-27
32619040-7	2020	Accordingly, a fer1-1 loss-of-function mutation confers reduced seed Fe accumulation, and suppresses ERF95-promoted seed Fe accumulation.	Iron	69-71	ferretin 1	Arabidopsis thaliana	15-19
32619040-7	2020	Accordingly, a fer1-1 loss-of-function mutation confers reduced seed Fe accumulation, and suppresses ERF95-promoted seed Fe accumulation.	Iron	121-123	ferretin 1	Arabidopsis thaliana	15-19
32424971-7	2020	A decreased serum iron level was also observed in the wildtype mice treated with an MOR antagonist.	Iron	18-22	opioid receptor, mu 1	Mus musculus	84-87
32239803-2	2020	For that reason, neoplastic cells have remodelled iron metabolism pathways, over-expressing genes encoding for iron uptake proteins, among which Transferrin Receptor-1 (TFR-1).	Iron	50-54	transferrin receptor	Canis lupus familiaris	145-167
32487538-8	2020	In the PG-PS model, roxadustat significantly decreased hepatic expression of hepcidin, a hormone responsible for iron sequestration and functional iron deficiency, and increased expression of two genes involved in duodenal iron absorption: divalent metal transporter 1 and duodenal cytochrome b.	Iron	113-117	hepcidin antimicrobial peptide	Rattus norvegicus	77-85
32729185-2	2020	The purpose of this study was to measure whether iron mediated osteoclast differentiation through regulation of triggering receptor expressed in myeloid cells-2 (Trem-2) expression and the PI3K/Akt signaling pathway.	Iron	49-53	thymoma viral proto-oncogene 1	Mus musculus	194-197
32387008-1	2020	BACKGROUND: Mutations in the X-linked gene WDR45 cause neurodegeneration with brain iron accumulation type 5.	Iron	84-88	WD repeat domain 45	Homo sapiens	43-48
32387008-15	2020	There is variable expressivity in the clinical phenotypes of individuals with WDR45 mutations, suggesting that this gene should be considered in the diagnostic evaluation of children with myelination abnormalities, iron deposition, developmental delay, and epilepsy depending on the age at evaluation.	Iron	215-219	WD repeat domain 45	Homo sapiens	78-83
32239803-2	2020	For that reason, neoplastic cells have remodelled iron metabolism pathways, over-expressing genes encoding for iron uptake proteins, among which Transferrin Receptor-1 (TFR-1).	Iron	50-54	transferrin receptor	Canis lupus familiaris	169-174
32239803-2	2020	For that reason, neoplastic cells have remodelled iron metabolism pathways, over-expressing genes encoding for iron uptake proteins, among which Transferrin Receptor-1 (TFR-1).	Iron	111-115	transferrin receptor	Canis lupus familiaris	145-167
32239803-2	2020	For that reason, neoplastic cells have remodelled iron metabolism pathways, over-expressing genes encoding for iron uptake proteins, among which Transferrin Receptor-1 (TFR-1).	Iron	111-115	transferrin receptor	Canis lupus familiaris	169-174
32239803-8	2020	The latter is an interesting finding, as TFR-1 is usually not expressed in normal vasculature, with the exception of normal brain vascular endothelium, where it allows transport of transferrin, and thus iron, into tissues, suggesting a similar function here to support cancer growth.	Iron	203-207	transferrin receptor	Canis lupus familiaris	41-46
32349646-6	2020	Mice lacking Fth in cardiomyocytes had decreased cardiac iron levels and increased oxidative stress, resulting in mild cardiac injury upon aging.	Iron	57-61	ferritin mitochondrial	Mus musculus	13-16
32821534-8	2020	In conclusion, the observed results suggest that iron transport and storage are altered in subjects with overweight/obesity, at the same time that they exhibit the characteristic features of insulin resistance.	Iron	49-53	insulin	Homo sapiens	191-198
32732975-5	2020	Interestingly, we found that canonical signaling pathways that regulate iron, including the Bmp/Smad and IL-6/Jak2/Stat3 pathways, play indispensable roles in mediating AUR"s effects.	Iron	72-76	interleukin 6	Mus musculus	105-109
32732975-5	2020	Interestingly, we found that canonical signaling pathways that regulate iron, including the Bmp/Smad and IL-6/Jak2/Stat3 pathways, play indispensable roles in mediating AUR"s effects.	Iron	72-76	signal transducer and activator of transcription 3	Mus musculus	115-120
32821534-0	2020	Relationship between iron status markers and insulin resistance: an exploratory study in subjects with excess body weight.	Iron	21-25	insulin	Homo sapiens	45-52
32751400-8	2020	Iron metabolism biomarkers and hemoglobin can contribute to risk stratification of patients, as initial anemia is associated with increased mortality, whereas alterations of iron homeostasis with a higher ferritin/transferrin ratio reflect more advanced inflammation and predicts subsequent insufficient pulmonary oxygenation with the need for ICU admission and mechanical ventilation.	Iron	174-178	transferrin	Homo sapiens	214-225
32922172-13	2020	Free iron nephrotoxicity and poor nutritional status with accumulated iron or transferrin deposition might contribute to ESRD.	Iron	5-9	transferrin	Homo sapiens	78-89
32726960-7	2020	We further demonstrate that Y39 is the main contributor to dityrosine formation of Fe-bound NAcalpha-Syn, while Y125 is the main residue involved in dityrosine crosslinks in unmetalated NAcalpha-Syn.	Iron	83-85	nascent polypeptide associated complex subunit alpha	Homo sapiens	92-100
32726960-8	2020	Our results confirm that iron coordination has a global effect on NAcalpha-Syn structure and reactivity.	Iron	25-29	nascent polypeptide associated complex subunit alpha	Homo sapiens	66-74
32718025-3	2020	Recently, several studies have identified intricate and complicated interplay between ferroptosis, ionizing radiation (IR), ATM (ataxia-telangiectasia mutated)/ATR (ATM and Rad3-related), and tumor suppressor p53, which signifies the participation of the DNA damage response (DDR) in iron-related cell death.	Iron	284-288	ATR serine/threonine kinase	Homo sapiens	160-163
32718025-3	2020	Recently, several studies have identified intricate and complicated interplay between ferroptosis, ionizing radiation (IR), ATM (ataxia-telangiectasia mutated)/ATR (ATM and Rad3-related), and tumor suppressor p53, which signifies the participation of the DNA damage response (DDR) in iron-related cell death.	Iron	284-288	tumor protein p53	Homo sapiens	209-212
30903157-2	2020	Here, we investigate susceptibility to atherosclerosis in a mouse model (ApoE-/- FPNwt/C326S), which develops the disease in the context of elevated non-transferrin bound serum iron (NTBI).	Iron	177-181	apolipoprotein E	Mus musculus	73-77
30903157-3	2020	METHODS AND RESULTS: Compared with normo-ferremic ApoE-/- mice, atherosclerosis is profoundly aggravated in iron-loaded ApoE-/- FPNwt/C326S mice, suggesting a pro-atherogenic role for iron.	Iron	108-112	apolipoprotein E	Mus musculus	120-124
30903157-8	2020	Consistently, a low-iron diet and iron chelation therapy strongly improved the course of the disease in ApoE-/- FPNwt/C326S mice.	Iron	20-24	apolipoprotein E	Mus musculus	104-108
30903157-8	2020	Consistently, a low-iron diet and iron chelation therapy strongly improved the course of the disease in ApoE-/- FPNwt/C326S mice.	Iron	34-38	apolipoprotein E	Mus musculus	104-108
32680469-2	2020	iron overload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress and lipid peroxidation.	Iron	0-4	transferrin	Homo sapiens	53-64
32708255-7	2020	The FET4 gene, which encodes an iron transporter, was found to be a multicopy suppressor of vps13Delta, pointing out the importance of iron in response to SDS stress.	Iron	32-36	Fet4p	Saccharomyces cerevisiae S288C	4-8
32708255-7	2020	The FET4 gene, which encodes an iron transporter, was found to be a multicopy suppressor of vps13Delta, pointing out the importance of iron in response to SDS stress.	Iron	135-139	Fet4p	Saccharomyces cerevisiae S288C	4-8
32793137-7	2020	The bla CTX-M-14 gene was located within an IS15DI-DeltaIS15DI-iroN-IS903B-bla CTX-M-14 -DeltaISEcp1-IS26 structure separated from the fosA3 gene in pT-HNK130-1, but was adjacent to fosA3 in pT-HNK130-3 in an inverted orientation.	Iron	63-67	fosfomycin resistance protein, FosA3	Escherichia coli	182-187
32691165-6	2020	For this reason, we analyzed the effect of the iron chelating compounds of ME0053, ME0055 and ME0192 on cell viability and proliferation rate both through ERK/MAPK and PI3K/AKT signal paths, and through the oncogenic Speedy/RINGO protein that is likely to have a regulatory effect on these two signaling pathways.	Iron	47-51	mitogen-activated protein kinase 1	Homo sapiens	155-158
32691165-6	2020	For this reason, we analyzed the effect of the iron chelating compounds of ME0053, ME0055 and ME0192 on cell viability and proliferation rate both through ERK/MAPK and PI3K/AKT signal paths, and through the oncogenic Speedy/RINGO protein that is likely to have a regulatory effect on these two signaling pathways.	Iron	47-51	AKT serine/threonine kinase 1	Homo sapiens	173-176
32680469-2	2020	iron overload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress and lipid peroxidation.	Iron	71-75	transferrin	Homo sapiens	53-64
32558533-4	2020	The exceptional OER performance can be attributed to the unique nanoarchitecture, high conductivity of CNTs matrix, and particularly the interaction between the Ni and Fe species in NiS/Fe3O4 heterostructural nanoparticles.	Iron	168-170	solute carrier family 5 member 5	Homo sapiens	182-185
32672503-1	2020	The effects of an adequate supply of vitamin A and iron, in comparison with diets low or absent in vitamin A and low in iron, on the mRNA expression of some biomarkers of iron homeostasis as hepcidin (Hamp), transferrin receptor-1 (Tfrc), iron regulatory protein-2 (Ireb2) and ferritin (Fth1) in rats were investigated.	Iron	51-55	hepcidin antimicrobial peptide	Rattus norvegicus	191-199
32672503-1	2020	The effects of an adequate supply of vitamin A and iron, in comparison with diets low or absent in vitamin A and low in iron, on the mRNA expression of some biomarkers of iron homeostasis as hepcidin (Hamp), transferrin receptor-1 (Tfrc), iron regulatory protein-2 (Ireb2) and ferritin (Fth1) in rats were investigated.	Iron	51-55	hepcidin antimicrobial peptide	Rattus norvegicus	201-205
32774708-4	2020	RESULTS: The results indicated that the levels of serum creatinine, blood urea nitrogen and serum iron, the renal iron content, and the kidney injury score were significantly decreased in the hepcidin group (P<0.05).	Iron	98-102	hepcidin antimicrobial peptide	Rattus norvegicus	192-200
32774708-4	2020	RESULTS: The results indicated that the levels of serum creatinine, blood urea nitrogen and serum iron, the renal iron content, and the kidney injury score were significantly decreased in the hepcidin group (P<0.05).	Iron	114-118	hepcidin antimicrobial peptide	Rattus norvegicus	192-200
32774708-5	2020	The serum hepcidin and the splenic iron content were significantly increased while the duodenal iron content was significantly decreased in the hepcidin group (P<0.05).	Iron	35-39	hepcidin antimicrobial peptide	Rattus norvegicus	144-152
32774708-5	2020	The serum hepcidin and the splenic iron content were significantly increased while the duodenal iron content was significantly decreased in the hepcidin group (P<0.05).	Iron	96-100	hepcidin antimicrobial peptide	Rattus norvegicus	144-152
32774708-7	2020	CONCLUSION: Hepcidin has a reno-protective effect in renal IRI by possibly promoting iron intake in the spleen, inhibiting iron absorption and exportation in the duodenum, alleviating the degree of serum iron, and reducing renal iron accumulation in the renal IRI.	Iron	85-89	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
32774708-7	2020	CONCLUSION: Hepcidin has a reno-protective effect in renal IRI by possibly promoting iron intake in the spleen, inhibiting iron absorption and exportation in the duodenum, alleviating the degree of serum iron, and reducing renal iron accumulation in the renal IRI.	Iron	123-127	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
32585109-0	2020	Development and Mechanistic Studies of Iron-Catalyzed Construction of Csp2-B Bonds via C-O Bond Activation.	Iron	39-43	regulator of calcineurin 2	Homo sapiens	70-74
32760266-5	2020	Iron has been shown to promote aggregation and pathogenicity of the characteristic aberrant proteins, beta-amyloid, tau, alpha-synuclein, and TDP43, in these diseases.	Iron	0-4	TAR DNA binding protein	Homo sapiens	142-147
32774708-7	2020	CONCLUSION: Hepcidin has a reno-protective effect in renal IRI by possibly promoting iron intake in the spleen, inhibiting iron absorption and exportation in the duodenum, alleviating the degree of serum iron, and reducing renal iron accumulation in the renal IRI.	Iron	123-127	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
32774708-7	2020	CONCLUSION: Hepcidin has a reno-protective effect in renal IRI by possibly promoting iron intake in the spleen, inhibiting iron absorption and exportation in the duodenum, alleviating the degree of serum iron, and reducing renal iron accumulation in the renal IRI.	Iron	123-127	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
32522834-5	2020	Accordingly, we identified stimulus-specific transcriptional signatures revealing T300A-dependent functional phenotypes that mechanistically link inflammatory cytokines, IFN response genes, steroid biosynthesis, and lipid metabolism in dendritic cells and iron homeostasis and lysosomal biogenesis in T lymphocytes.	Iron	256-260	interferon alpha 1	Homo sapiens	170-173
32668236-3	2020	The screen reveals that NMD requires lysosomal acidification, which allows transferrin-mediated iron uptake, which, in turn, is necessary for iron-sulfur (Fe-S) cluster biogenesis.	Iron	96-100	transferrin	Homo sapiens	75-86
32668236-3	2020	The screen reveals that NMD requires lysosomal acidification, which allows transferrin-mediated iron uptake, which, in turn, is necessary for iron-sulfur (Fe-S) cluster biogenesis.	Iron	155-159	transferrin	Homo sapiens	75-86
32620712-7	2020	The age-related reduction of hepatic copper levels was associated with reduced expression of copper transporters, whereas the increased hepatic iron concentrations correlated positively with proinflammatory mediators and Nrf2-induced ferritin H levels.	Iron	144-148	nuclear factor, erythroid derived 2, like 2	Mus musculus	221-225
32243658-4	2020	The monoatomic and highly dispersed Fe ions in MPGs can both serve as the efficient cross-linkers of gel network, and interestedly also the vital active center of multienzyme mimic of superoxide dismutase (SOD) and peroxidase (POD) activity.	Iron	36-38	superoxide dismutase 1	Homo sapiens	184-204
32243658-4	2020	The monoatomic and highly dispersed Fe ions in MPGs can both serve as the efficient cross-linkers of gel network, and interestedly also the vital active center of multienzyme mimic of superoxide dismutase (SOD) and peroxidase (POD) activity.	Iron	36-38	superoxide dismutase 1	Homo sapiens	206-209
32660103-6	2020	Proteomic profiling analysis suggested that the hPXR liver proteome is affected by antitubercular therapy to disrupt [Fe-S] cluster assembly machinery, [2Fe-2S] cluster-containing proteins, cytochrome P450 enzymes, heme biosynthesis, homocysteine catabolism, oxidative stress responses, vitamin B3 metabolism, and vitamin B6 metabolism.	Iron	118-122	nuclear receptor subfamily 1 group I member 2	Homo sapiens	48-52
32152203-6	2020	RESULTS: By investigating PCPG cells with low SDHB levels, we show that pseudohypoxia resulted in elevated expression of iron transport proteins, including transferrin (TF), transferrin receptor 2 (TFR2) and the divalent metal transporter 1 (SLC11A2; DMT1), leading to iron accumulation.	Iron	121-125	transferrin	Homo sapiens	156-167
32152203-6	2020	RESULTS: By investigating PCPG cells with low SDHB levels, we show that pseudohypoxia resulted in elevated expression of iron transport proteins, including transferrin (TF), transferrin receptor 2 (TFR2) and the divalent metal transporter 1 (SLC11A2; DMT1), leading to iron accumulation.	Iron	121-125	transferrin	Homo sapiens	169-171
32620712-7	2020	The age-related reduction of hepatic copper levels was associated with reduced expression of copper transporters, whereas the increased hepatic iron concentrations correlated positively with proinflammatory mediators and Nrf2-induced ferritin H levels.	Iron	144-148	ferritin mitochondrial	Mus musculus	234-244
32164430-0	2020	Elevated Labile Iron Levels in CD4 and CD8 T Cells From HIV Positive Individuals With Undetectable Viral Load.	Iron	16-20	CD4 molecule	Homo sapiens	31-34
32414791-10	2020	The molecular function of yeast glutaredoxins Grx3 and Grx4 has an enormous interest since both proteins are required to maintain a correct iron homeostasis and an efficient response to oxidative stress.	Iron	140-144	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	55-59
32488585-6	2020	Analysis of the results between the first, third, and fifth dive showed that the erythropoietin increase at the third (pre-dive p = 0.009; post-dive p = 0.004) and fifth dive (pre-dive p < 0.001; post-dive p = 0.003) was not accompanied by changes in RBC count, hemoglobin, iron, and ferritin.	Iron	274-278	erythropoietin	Homo sapiens	81-95
32129080-6	2020	The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2.	Iron	170-174	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	35-39
31960438-8	2020	Additionally, pre-miR-214 overexpression increased the malondialdehyde and reactive oxygen species levels, upregulated Fe2+ concentration, and decreased glutathione levels in cancer cells exposed to erastin.	Iron	119-123	microRNA 214	Homo sapiens	18-25
32129080-6	2020	The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2.	Iron	77-81	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	35-39
32141111-5	2020	In the present study, we investigated the effects of iron on mRNA expression profiles of fifteen key genes (IP3 R1/2/3, RYR1/2, SERCA1/2/3, NCX1/2/3, PMCA1/2/3, and PMCA4) related to calcium homeostasis in parental cell line K562 and its subclone doxorubicin resistant K562 cells.	Iron	53-57	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	108-118
32141111-6	2020	According to the DeltaDeltaCt method with a two-fold expression difference (p < 0.05) as a cut off level, although iron showed differential effects on most of the genes, IP3 R and PMCA genes were especially determined significantly changed.	Iron	115-119	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	170-175
32393899-5	2020	In contrast, the allosteric inhibitor 3-acetyl-11-keto-beta-boswellic acid (AKBA) from frankincense wedges between the membrane-binding and catalytic domains of 5-LOX, some 30 A from the catalytic iron.	Iron	197-201	arachidonate 5-lipoxygenase	Homo sapiens	161-166
31693761-0	2020	Iron Potentiates Microglial Interleukin-1beta Secretion Induced by Amyloid-beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	28-45
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	53-57	interleukin 1 beta	Homo sapiens	31-39
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	138-142	interleukin 1 beta	Homo sapiens	31-39
31693761-11	2020	Immunoblotting and immunofluorescence microscopy indicate that iron enhances Abeta activation of NF-kappaB signaling to promote IL-1beta synthesis.	Iron	63-67	interleukin 1 beta	Homo sapiens	128-136
31693761-13	2020	Most importantly, iron appears to exacerbate the pro-inflammatory effects of Abeta to increase IL-1beta levels.	Iron	18-22	interleukin 1 beta	Homo sapiens	95-103
32418819-4	2020	Oral iron supplementation at 6-12 mg/kg per day was used to maintain a transferrin saturation of >20% during r-HuEPO treatment.	Iron	5-9	transferrin	Homo sapiens	71-82
32276991-1	2020	Iron regulatory protein 2 (IRP2) is a key regulator of iron homeostasis and is found to be altered in several types of human cancer.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	0-25
32276991-1	2020	Iron regulatory protein 2 (IRP2) is a key regulator of iron homeostasis and is found to be altered in several types of human cancer.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	27-31
33100783-4	2020	Renal erythropoietin has an important role in the balance of vascular active substances, such as prostaglandins and thromboxanes; therefore, patients undergoing hemodialysis observe decreased production of erythropoietin with iron loss through hemodialysis machine as well as weakened iron absorption and mobilization from the intestine to the bloodstream.	Iron	226-230	erythropoietin	Homo sapiens	6-20
33100783-4	2020	Renal erythropoietin has an important role in the balance of vascular active substances, such as prostaglandins and thromboxanes; therefore, patients undergoing hemodialysis observe decreased production of erythropoietin with iron loss through hemodialysis machine as well as weakened iron absorption and mobilization from the intestine to the bloodstream.	Iron	226-230	erythropoietin	Homo sapiens	206-220
33100783-4	2020	Renal erythropoietin has an important role in the balance of vascular active substances, such as prostaglandins and thromboxanes; therefore, patients undergoing hemodialysis observe decreased production of erythropoietin with iron loss through hemodialysis machine as well as weakened iron absorption and mobilization from the intestine to the bloodstream.	Iron	285-289	erythropoietin	Homo sapiens	6-20
33100783-4	2020	Renal erythropoietin has an important role in the balance of vascular active substances, such as prostaglandins and thromboxanes; therefore, patients undergoing hemodialysis observe decreased production of erythropoietin with iron loss through hemodialysis machine as well as weakened iron absorption and mobilization from the intestine to the bloodstream.	Iron	285-289	erythropoietin	Homo sapiens	206-220
33100783-8	2020	In addition, there was a decreased level of iron status in all parameters such as packed cell volume (%), TIBC, UIBC, iron free, and transferrin except ferritin; there was an increased level of iron status in all parameters in patients compared with control groups.	Iron	44-48	transferrin	Homo sapiens	133-144
32409084-6	2020	In isolated rat aortic rings NO production was also reduced by HO generated during Fe corrosion, as indicated by the protective role of catalase.	Iron	83-85	catalase	Rattus norvegicus	136-144
32418885-5	2020	Interestingly, iron chelation has been shown in vitro to suppress endothelial inflammation in viral infection, which is the main pathophysiologic mechanism behind systemic organ involvement induced by SARS-CoV-2, by inhibiting IL-6 synthesis through decreasing NF-kB.	Iron	15-19	interleukin 6	Homo sapiens	227-231
32579049-4	2020	Results: In the COVID-19 patients hemoglobin is decreasing and protoporphyrin is increasing, generating an extremely harmful accumulation of iron ions in the bloodstream, which are able to induce an intense inflammatory process in the body with a consequent increase in C-reactive protein and albumin.	Iron	141-145	C-reactive protein	Homo sapiens	270-288
32541839-0	2020	Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways.	Iron	0-4	BCL2 interacting protein 3	Homo sapiens	80-85
32541839-5	2020	Particularly, reports on the effects of iron chelation on mTOR complexes are inconsistent or controversial.	Iron	40-44	mechanistic target of rapamycin kinase	Homo sapiens	58-62
32541839-8	2020	Instead, activation of AMPK pathway mainly and activation of both HIF-1/REDD1 and Bnip3 pathways partially contribute to iron chelation-induced mTORC1 inhibition.	Iron	121-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-71
32541839-8	2020	Instead, activation of AMPK pathway mainly and activation of both HIF-1/REDD1 and Bnip3 pathways partially contribute to iron chelation-induced mTORC1 inhibition.	Iron	121-125	BCL2 interacting protein 3	Homo sapiens	82-87
32579049-4	2020	Results: In the COVID-19 patients hemoglobin is decreasing and protoporphyrin is increasing, generating an extremely harmful accumulation of iron ions in the bloodstream, which are able to induce an intense inflammatory process in the body with a consequent increase in C-reactive protein and albumin.	Iron	141-145	albumin	Homo sapiens	293-300
32366593-11	2020	The transferrin binding proteins, TbpA and TbpB, are thought to be a key iron acquisition system in H. somni; however, despite their importance, H. somni TbpA and TbpB were previously shown to be cattle transferrin-specific.	Iron	73-77	transferrin	Homo sapiens	4-15
32610126-0	2020	Counter Regulation of Spic by NF-kappaB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.	Iron	85-89	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-39
32610126-7	2020	Taken together, our findings uncover a pathway wherein counter-regulation of Spic by NF-kappaB and STATs attune inflammatory responses and iron metabolism in macrophages.	Iron	139-143	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
32576938-0	2020	The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.	Iron	4-8	DNA replication helicase/nuclease 2	Homo sapiens	34-38
32714308-9	2020	Since NRAMP1 has been shown to influence the survival of intracellular pathogens such as M. bovis through the sequestering of iron, it is possible that cattle expressing the alternative G allele might have an increased resistance to bTB through increased NRAMP1 expression in their macrophages.	Iron	126-130	solute carrier family 11 member 1	Bos taurus	6-12
32587293-3	2020	Here we investigate the interaction of the AD peptide beta-amyloid (Abeta) with the iron storage protein ferritin, to establish whether interactions between these two species are a potential source of low-oxidation-state iron in AD.	Iron	84-88	amyloid beta precursor protein	Homo sapiens	68-73
32587293-5	2020	Such findings strongly implicate Abeta in the altered iron handling and increased oxidative stress observed in AD pathogenesis.	Iron	54-58	amyloid beta precursor protein	Homo sapiens	33-38
32576938-0	2020	The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.	Iron	4-8	DNA replication helicase/nuclease 2	Homo sapiens	85-89
32576938-2	2020	DNA2 contains an iron-sulphur (FeS) cluster, conserved in eukaryotes and in a related bacterial nuclease.	Iron	17-21	DNA replication helicase/nuclease 2	Homo sapiens	0-4
32612843-0	2020	Effect of Maintenance Intravenous Iron Treatment on Erythropoietin Dose in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial.	Iron	34-38	erythropoietin	Homo sapiens	52-66
32612843-2	2020	Objective: To examine the effect of IV iron supplementation to different targets of serum ferritin on erythropoietin dose and inflammatory markers in chronic hemodialysis (HD) patients with functional iron deficiency anemia.	Iron	39-43	erythropoietin	Homo sapiens	102-116
32612843-12	2020	The erythropoietin resistance index was significantly decreased in the high-serum ferritin group compared to the low-serum ferritin group after receiving IV iron in the 6-week titration period (mean difference: -113.43 +- 189.14 vs 41.08 +- 207.38 unit/week/g/dL; P < .001) and 3-month follow-up period (mean differences: -88.88 +- 234.43 vs -10.48 +- 217.75 unit/week/g/dL; P = .02).	Iron	157-161	erythropoietin	Homo sapiens	4-18
32612843-14	2020	Conclusion: Maintaining a serum ferritin level of 600 to 700 ng/mL by IV iron administration of approximately 200 mg per month as a maintenance protocol can decrease erythropoietin dose requirements in chronic HD patients with functional iron deficiency anemia.	Iron	73-77	erythropoietin	Homo sapiens	166-180
32685019-7	2020	GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin).	Iron	26-30	glutaredoxin 5	Mus musculus	0-5
32685019-7	2020	GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin).	Iron	85-89	glutaredoxin 5	Mus musculus	0-5
32685019-7	2020	GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin).	Iron	85-89	glutaredoxin 5	Mus musculus	0-5
32685019-7	2020	GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin).	Iron	85-89	glutaredoxin 5	Mus musculus	0-5
32497515-4	2020	This study provides initial insight into these processes for a range of transition metals-Ti(IV), Co(III), Fe(III), Ga(III), Cr(III), Fe(II), Zn(II)-through fully atomistic, extensive quantum mechanical/discrete molecular dynamics sampling and provides, to our knowledge, a new technique we developed to calculate relative binding affinities between metal cations and the protein.	Iron	107-109	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	110-113
32497515-4	2020	This study provides initial insight into these processes for a range of transition metals-Ti(IV), Co(III), Fe(III), Ga(III), Cr(III), Fe(II), Zn(II)-through fully atomistic, extensive quantum mechanical/discrete molecular dynamics sampling and provides, to our knowledge, a new technique we developed to calculate relative binding affinities between metal cations and the protein.	Iron	107-109	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	110-113
32416595-8	2020	Baseline separation between the Hp-Hb complex and Tf was achieved by developing a sample preparation procedure which involved the chelating agent-based mobilization of Fe from Tf to a small molecular weight Fe complex.	Iron	168-170	transferrin	Homo sapiens	50-52
32202031-6	2020	These include NifS and NifU, found primarily in aerobic species, suggesting that these genes are necessary for accommodating the high demand for Fe-S clusters during aerobic nitrogen fixation.	Iron	145-149	iron-sulfur cluster assembly enzyme	Homo sapiens	23-27
32201101-1	2020	BACKGROUND: Low transferrin saturation (TSAT) or reduced serum ferritin level are suggestive of iron deficiency but the relationship between iron parameters and outcomes has not been systematically evaluated in older adults with heart failure (HF) and anemia.	Iron	96-100	transferrin	Homo sapiens	16-27
32416595-8	2020	Baseline separation between the Hp-Hb complex and Tf was achieved by developing a sample preparation procedure which involved the chelating agent-based mobilization of Fe from Tf to a small molecular weight Fe complex.	Iron	168-170	transferrin	Homo sapiens	176-178
32416595-8	2020	Baseline separation between the Hp-Hb complex and Tf was achieved by developing a sample preparation procedure which involved the chelating agent-based mobilization of Fe from Tf to a small molecular weight Fe complex.	Iron	207-209	transferrin	Homo sapiens	50-52
32545266-1	2020	Hepatic peptide hormone hepcidin, a key regulator of iron metabolism, is induced by inflammatory cytokine interleukin-6 (IL-6) in the pathogenesis of anemia of inflammation or microbial infections.	Iron	53-57	interleukin 6	Mus musculus	106-119
32545266-1	2020	Hepatic peptide hormone hepcidin, a key regulator of iron metabolism, is induced by inflammatory cytokine interleukin-6 (IL-6) in the pathogenesis of anemia of inflammation or microbial infections.	Iron	53-57	interleukin 6	Mus musculus	121-125
32545266-9	2020	These results reveal a previously unrecognized role of EGCG-inducible SMILE in the IL-6-dependent transcriptional regulation of iron metabolism.	Iron	128-132	interleukin 6	Mus musculus	83-87
32513913-0	2020	The relationship between iron metabolism, stress hormones, and insulin resistance in gestational diabetes mellitus.	Iron	25-29	insulin	Homo sapiens	63-70
32513913-5	2020	Multiple linear regression was used to analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress.	Iron	72-76	insulin	Homo sapiens	115-122
32513913-1	2020	AIM: To analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress in gestational diabetes mellitus (GDM).	Iron	41-45	insulin	Homo sapiens	84-91
32513913-10	2020	CONCLUSIONS: Iron metabolism index is related to insulin resistance in GDM women.	Iron	13-17	insulin	Homo sapiens	49-56
32380835-5	2020	Recoveries of the enrichment step from spiked bovine serum albumin digests were above 80% for the commercial Fe-IMAC kit and the Strata X-AW sorbent.	Iron	109-111	albumin	Homo sapiens	53-66
32124285-6	2020	In contrast, extremely fast PrP degradation was achieved through the ZVI/PS process (0.3304 < k < 0.9212 min-1), with removal percentages above 97.5%; in this case, paraben degradation was hindered for a ZVI dosage beyond 40 mg L-1.	Iron	69-72	immunoglobulin kappa variable 1-16	Homo sapiens	228-231
32351167-5	2020	Heterologous expression of an Arabidopsis thaliana monothiol glutaredoxin S17 (GRXS17) suppresses the over-accumulation of iron in the Saccharomyces cerevisiae Grx3/Grx4 mutant and disruption of GRXS17 causes plant sensitivity to exogenous oxidants and iron deficiency stress.	Iron	123-127	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	165-169
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	zinc induced facilitator 1	Arabidopsis thaliana	244-248
32278200-6	2020	Further mechanistic research confirmed iron overload is caused by reactive oxygen species (ROS)-driven hepcidin disorder in hepatic cells, and the increase of hepcidin is regulated by the translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).	Iron	39-43	NFE2 like bZIP transcription factor 2	Homo sapiens	205-248
32420456-2	2020	Interferon-gamma (IFN-gamma) is elevated during malaria infection and is thought to influence erythropoiesis and iron status.	Iron	113-117	interferon gamma	Homo sapiens	0-16
32420456-2	2020	Interferon-gamma (IFN-gamma) is elevated during malaria infection and is thought to influence erythropoiesis and iron status.	Iron	113-117	interferon gamma	Homo sapiens	18-27
32420456-4	2020	We investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes of IFNG in relation to nutritional iron status and anaemia in Gambian children over a malaria season.	Iron	125-129	interferon gamma	Homo sapiens	93-97
32100150-3	2020	Increased brain iron in the Npc1-/- mouse model of NP-C may potentially contribute to neurodegeneration, similar to neurodegenerative diseases such as Alzheimer"s and Parkinson"s diseases.	Iron	16-20	NPC intracellular cholesterol transporter 1	Mus musculus	28-32
32100150-8	2020	The outcome of our study indicated that, despite increased brain iron, Npc1-/- mice were vulnerable to pharmacological iron depletion, especially in early life.	Iron	119-123	NPC intracellular cholesterol transporter 1	Mus musculus	71-75
31628998-8	2020	Iron bioavailability (assessed by mean corpuscular volume [MCV], mean corpuscular haemoglobin [MCH], transferrin saturation, and serum levels of iron) was inversely correlated with BMI in adolescents with NAFLD (P <= .01 for all, adjusted for sex) but not in adolescents without NAFLD (P > .30).	Iron	0-4	transferrin	Homo sapiens	101-112
32209423-7	2020	There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice.	Iron	25-29	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	148-161
32134556-8	2020	The introduction of the nickel and iron magnetic polymers increased the pressure of collapse substantially (7.38-17.51 cmH2 O).	Iron	35-39	troponin T2, cardiac type	Homo sapiens	119-123
32196080-5	2020	We further show that NNT loss elicits mitochondrial dysfunction independent of substantial increases in oxidative stress, but rather marked by the diminished activities of proteins dependent on resident iron-sulfur clusters.	Iron	203-207	nicotinamide nucleotide transhydrogenase	Mus musculus	21-24
32209423-7	2020	There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice.	Iron	25-29	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	163-167
32385772-2	2020	The TMPRSS6 (Transmembrane Serine Protease 6) gene encodes matriptase-2, which plays an important role in iron hemostasis as the hepcidin regulator and may play a role in breast cancer susceptibility.	Iron	106-110	transmembrane serine protease 6	Homo sapiens	59-71
32614313-5	2020	We have investigated a local treatment with transferrin, the natural iron carrier, to control these pathological pathways and iron dysfunction, without side effects.	Iron	69-73	transferrin	Homo sapiens	44-55
32385772-2	2020	The TMPRSS6 (Transmembrane Serine Protease 6) gene encodes matriptase-2, which plays an important role in iron hemostasis as the hepcidin regulator and may play a role in breast cancer susceptibility.	Iron	106-110	transmembrane serine protease 6	Homo sapiens	4-11
32476270-10	2020	Thus, improvement of iron utilization in a CKD model using EPO and a HIF-PHDi significantly reduced iFGF23, demonstrating that anemia is a primary driver of FGF23, and that management of iron utilization in patients with CKD may translate to modifiable outcomes in mineral metabolism.	Iron	21-25	erythropoietin	Homo sapiens	59-62
32032734-0	2020	Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function.	Iron	13-17	Cation-transporting ATPase;Cation_ATPase_N domain-containing protein;putative cation-transporting ATPase W08D2.5	Caenorhabditis elegans	43-49
32032734-5	2020	Here we show that catp-6 mutant worms have defective autophagy and lysosomal function, demonstrate characteristic PD phenotypes including reduced motor function and dysregulated iron metabolism.	Iron	178-182	Cation-transporting ATPase;Cation_ATPase_N domain-containing protein;putative cation-transporting ATPase W08D2.5	Caenorhabditis elegans	18-24
32335809-7	2020	Iron overload is also associated with increased IL-10 and lower CCL11 levels, but these alterations are not significantly associated with depression.	Iron	0-4	C-C motif chemokine ligand 11	Homo sapiens	64-69
32463488-3	2020	Accumulated iron from blood transfusions may be deposited in vital organs including the heart, liver and endocrine organs such as the pituitary glands which can affect growth hormone production.	Iron	12-16	growth hormone 1	Homo sapiens	168-182
32172712-9	2020	An inferred increase in Fe transfer from bone marrow to the liver paralleled higher hepatic Fe concentrations and ferritin heavy-chain mRNA levels in the HF diet-fed animals, suggesting that liver Fe accumulation occurred at least in part due to a favoured liver erythrocyte uptake.	Iron	24-26	ferritin heavy chain 1	Rattus norvegicus	114-134
32143096-9	2020	The sorbent is tested for the removal of As(V) from mining effluents containing high concentration of iron and traces of zinc.	Iron	102-106	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
32481699-8	2020	The combined effect of pH, metal complexation capacity, and the presence of Fe and Mn oxides added to wheat straw biochar resulted in an effective reduction of soluble Co (II), showing high efficiency of this material for cobalt sorption in contaminated soils.	Iron	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-175
32456214-8	2020	However, the ability to reduce iron ions (FRAP) was significantly lower only in stimulated and non-stimulated saliva of patients with periodontitis.	Iron	31-35	mechanistic target of rapamycin kinase	Homo sapiens	42-46
32301469-0	2020	Characterization of the Fe metalloproteome of a ubiquitous marine heterotroph, Pseudoalteromonas (BB2-AT2): multiple bacterioferritin copies enable significant Fe storage.	Iron	24-26	gastrin releasing peptide receptor	Homo sapiens	98-105
32647792-3	2020	Increased systemic iron levels eventually lead to the saturation of the physiological systemic iron carrier transferrin and the occurrence of non-transferrin-bound iron (NTBI) together with its reactive fraction, the labile plasma iron (LPI).	Iron	19-23	transferrin	Homo sapiens	108-119
32647792-3	2020	Increased systemic iron levels eventually lead to the saturation of the physiological systemic iron carrier transferrin and the occurrence of non-transferrin-bound iron (NTBI) together with its reactive fraction, the labile plasma iron (LPI).	Iron	19-23	transferrin	Homo sapiens	146-157
32621410-3	2020	Among these epigenetic regulators, DNA hypermethylation of the promoter region of FPN, TFR2, HAMP, HJV and bone morphogenetic protein 6 (BMP6) genes result in inhibitory effect on the expression of these iron-related gene.	Iron	204-208	bone morphogenetic protein 6	Homo sapiens	107-135
32621410-3	2020	Among these epigenetic regulators, DNA hypermethylation of the promoter region of FPN, TFR2, HAMP, HJV and bone morphogenetic protein 6 (BMP6) genes result in inhibitory effect on the expression of these iron-related gene.	Iron	204-208	bone morphogenetic protein 6	Homo sapiens	137-141
32443740-8	2020	RESULTS: After adjusting for age, gender, C-reactive protein (CRP), and body mass index (BMI), a negative association was found between whole blood iron, ferritin, and TBI and incidence of reduced HDL-C (odds ratio (OR) = 0.63, 0.49, and 0.57, respectively).	Iron	148-152	C-reactive protein	Homo sapiens	42-60
32456086-9	2020	Our data prove that high amount of iron coexists with an impairment of cytosolic calcium in PKAN glutamatergic neurons, indicating both, iron and calcium dys-homeostasis, as actors in pathogenesis of the disease.	Iron	137-141	pantothenate kinase 2	Homo sapiens	92-96
32456086-1	2020	Pantothenate Kinase-associated Neurodegeneration (PKAN) belongs to a wide spectrum of diseases characterized by brain iron accumulation and extrapyramidal motor signs.	Iron	118-122	pantothenate kinase 2	Homo sapiens	0-48
32456086-1	2020	Pantothenate Kinase-associated Neurodegeneration (PKAN) belongs to a wide spectrum of diseases characterized by brain iron accumulation and extrapyramidal motor signs.	Iron	118-122	pantothenate kinase 2	Homo sapiens	50-54
32456086-4	2020	Results obtained by inductively coupled plasma mass spectrometry indicated a higher amount of total cellular iron in PKAN glutamatergic neurons with respect to controls.	Iron	109-113	pantothenate kinase 2	Homo sapiens	117-121
32456060-6	2020	The iron-enriched diet increased Hamp mRNA levels, as well as pSMAD1/5/8 and pSTAT3 protein levels, while no difference was observed in Hjv, Bmp6, Smad7, Tfr1, and Hfe mRNA levels and LIP compared to the CT group.	Iron	4-8	hepcidin antimicrobial peptide	Rattus norvegicus	33-37
32456060-7	2020	The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group.	Iron	45-49	hepcidin antimicrobial peptide	Rattus norvegicus	83-87
32456060-7	2020	The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group.	Iron	45-49	bone morphogenetic protein 6	Rattus norvegicus	94-98
32456060-7	2020	The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group.	Iron	45-49	hepcidin antimicrobial peptide	Rattus norvegicus	190-194
32456060-8	2020	Therefore, the inhibition of hepatic hepcidin by tucum-do-cerrado consumption may involve the downregulation of intestinal Dmt1 and hepatic Hjv expression and deacetylation mediated by SIRT1 by a mechanism that is independent of tissue iron content.	Iron	236-240	hepcidin antimicrobial peptide	Rattus norvegicus	37-45
32456060-8	2020	Therefore, the inhibition of hepatic hepcidin by tucum-do-cerrado consumption may involve the downregulation of intestinal Dmt1 and hepatic Hjv expression and deacetylation mediated by SIRT1 by a mechanism that is independent of tissue iron content.	Iron	236-240	sirtuin 1	Rattus norvegicus	185-190
32456060-9	2020	However, in excess iron conditions, the modulation of hepatic hepcidin expression by tucum-do-cerrado seems to be partially mediated by the inflammatory signaling pathway, as well as involves the chelating activity of tucum-do-cerrado.	Iron	19-23	hepcidin antimicrobial peptide	Rattus norvegicus	62-70
32443740-8	2020	RESULTS: After adjusting for age, gender, C-reactive protein (CRP), and body mass index (BMI), a negative association was found between whole blood iron, ferritin, and TBI and incidence of reduced HDL-C (odds ratio (OR) = 0.63, 0.49, and 0.57, respectively).	Iron	148-152	C-reactive protein	Homo sapiens	62-65
31840403-6	2020	Distinct Fe-related gene repertories of HNLC ecotypes CRD1 and CRD2 also highlight how co-existing ecotypes have evolved independent approaches to life in low-Fe habitats.	Iron	9-11	CORD1	Homo sapiens	54-58
32477344-5	2020	Some iron chelators have been shown to modulate cellular metabolism through the regulation of HIF1alpha.	Iron	5-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-103
32608847-5	2020	The PO43- with low-concentration (2 mmol L-1), humic acid and fulvic acid (2 mg L-1 and 10 mg L-1) loaded on iron mineral nanoparticles changed their surface charge and further improved the stability of FHNPs and GTNPs at medium and high pH.	Iron	109-113	L1 cell adhesion molecule	Homo sapiens	80-90
31726018-10	2020	Interleukin-6 and monocyte chemotactic protein-1 levels in the BAL fluid increased significantly from baseline in iron-deficient mice, but not in normal diet mice.	Iron	114-118	interleukin 6	Mus musculus	0-13
31976584-1	2020	Ferritin is a ubiquitous and conserved iron storage protein that plays a significant role in host detoxification, iron storage, and immune response.	Iron	39-43	ferritin	Bombyx mori	0-8
31976584-1	2020	Ferritin is a ubiquitous and conserved iron storage protein that plays a significant role in host detoxification, iron storage, and immune response.	Iron	114-118	ferritin	Bombyx mori	0-8
31473895-6	2020	The presence of 50 muM Zn significantly decreased (P &lt; 0.05) cellular Cu uptake in HT-29 cells at 0.5:1 Cu:Zn ratio and also the cellular Fe uptake at the ratios 0.5:1, 2:1, and 4:1 Fe:Zn.	Iron	141-143	latexin	Homo sapiens	19-22
31473895-7	2020	The presence of 50 muM Fe significantly (P &lt; 0.05) decreased cellular Cu uptake at the ratios 1:1, 2:1, and 4:1 Cu:Fe.	Iron	23-25	latexin	Homo sapiens	19-22
31473895-7	2020	The presence of 50 muM Fe significantly (P &lt; 0.05) decreased cellular Cu uptake at the ratios 1:1, 2:1, and 4:1 Cu:Fe.	Iron	118-120	latexin	Homo sapiens	19-22
31473895-9	2020	There was a decrease in concentration of IL-1beta and TNF-alpha (P &lt; 0.05) with an increasing extracellular concentration of Cu and Fe.	Iron	135-137	interleukin 1 beta	Homo sapiens	41-49
32176452-8	2020	Moreover, a positive correlation was demonstrated between the MRP1 expression levels and bone marrow iron storage in pALL patients.	Iron	101-105	ATP binding cassette subfamily C member 1	Homo sapiens	62-66
31840403-4	2020	HNLC ecotype CRD1 strains have greater physiological tolerance to low Fe congruent with their expanded repertoire of Fe transporter, storage, and regulatory genes compared to other ecotypes.	Iron	70-72	CORD1	Homo sapiens	13-17
31840403-4	2020	HNLC ecotype CRD1 strains have greater physiological tolerance to low Fe congruent with their expanded repertoire of Fe transporter, storage, and regulatory genes compared to other ecotypes.	Iron	117-119	CORD1	Homo sapiens	13-17
32457891-3	2020	Herein, a tumor microenvironment (TME)-responsive intelligent bimetallic nanoagents (HSA-Pd-Fe-Ce6 NAs) composed of human serum albumin (HSA), palladium-iron (Pd-Fe) bimetallic particles, and chlorin e6 (Ce6) was designed for effective combination phototherapy.	Iron	24-28	albumin	Homo sapiens	122-135
31972529-3	2020	Herein, nano zerovalent iron (nZVI) particles were incorporated on the surface of sludge-based biochar (SBC) to fabricate a dual-affinity sorbent that attracts both the arsenate and benzene rings of ROX.	Iron	24-28	MAX network transcriptional repressor	Homo sapiens	199-202
31972529-5	2020	The enhanced elimination of ROX molecules was ascribed to synergetic adsorption and degradation reactions, through pi-pi* electron donor/acceptor interactions, H-bonding, and As-O-Fe coordination.	Iron	175-182	MAX network transcriptional repressor	Homo sapiens	28-31
31990410-4	2020	Expression of the iron regulatory peptide hepcidin is negatively regulated by the serine protease TMPRSS6.	Iron	18-22	transmembrane serine protease 6	Homo sapiens	98-105
31990410-5	2020	Hepcidin induction by siRNA-mediated inhibition of TMPRSS6 expression reduces iron availability and induces iron deficiency.	Iron	78-82	transmembrane serine protease 6	Homo sapiens	51-58
31840403-6	2020	Distinct Fe-related gene repertories of HNLC ecotypes CRD1 and CRD2 also highlight how co-existing ecotypes have evolved independent approaches to life in low-Fe habitats.	Iron	159-161	CORD1	Homo sapiens	54-58
31840403-8	2020	HNLC ecotype CRD1 interestingly was most similar to coastal ecotype I in Fe physiology and Fe-related gene content, suggesting populations from these different biomes experience similar Fe-selective conditions.	Iron	91-93	CORD1	Homo sapiens	13-17
31840403-8	2020	HNLC ecotype CRD1 interestingly was most similar to coastal ecotype I in Fe physiology and Fe-related gene content, suggesting populations from these different biomes experience similar Fe-selective conditions.	Iron	91-93	CORD1	Homo sapiens	13-17
32441176-13	2020	Positive correlations of urine beta2-MG, urine NGAL, and serum endocan levels with serum ferritin concentration indicated that iron deposition was associated with endothelial damage and renal injury.	Iron	127-131	ATPase H+ transporting V0 subunit a2	Homo sapiens	31-36
32202346-6	2020	Iron chelation resulted in an increase in BCL2/Adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) and BNIP3-like gene and protein levels, and the appearance of mitochondria encapsulated by lysosome-like vesicular structures in myotubes.	Iron	0-4	BCL2 interacting protein 3	Homo sapiens	42-98
32202346-6	2020	Iron chelation resulted in an increase in BCL2/Adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) and BNIP3-like gene and protein levels, and the appearance of mitochondria encapsulated by lysosome-like vesicular structures in myotubes.	Iron	0-4	BCL2 interacting protein 3	Homo sapiens	100-105
32202346-6	2020	Iron chelation resulted in an increase in BCL2/Adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) and BNIP3-like gene and protein levels, and the appearance of mitochondria encapsulated by lysosome-like vesicular structures in myotubes.	Iron	0-4	BCL2 interacting protein 3	Homo sapiens	111-116
31738088-1	2020	PURPOSE OF THE STUDY: Pantothenate Kinase-associated Neurodegeneration (PKAN) is a form of Neurodegeneration with brain iron accumulation (NBIA) due to gene mutations.	Iron	114-124	pantothenate kinase 2	Homo sapiens	22-70
31738088-1	2020	PURPOSE OF THE STUDY: Pantothenate Kinase-associated Neurodegeneration (PKAN) is a form of Neurodegeneration with brain iron accumulation (NBIA) due to gene mutations.	Iron	114-124	pantothenate kinase 2	Homo sapiens	72-76
31906761-5	2020	The iron accumulation triggered an iron regulatory protein-ferroportin 1 axis to increase serum iron levels.	Iron	4-8	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	59-72
31906761-5	2020	The iron accumulation triggered an iron regulatory protein-ferroportin 1 axis to increase serum iron levels.	Iron	35-39	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	59-72
31906761-5	2020	The iron accumulation triggered an iron regulatory protein-ferroportin 1 axis to increase serum iron levels.	Iron	35-39	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	59-72
32143980-3	2020	Two of these studies suggest that an epistatic interaction between variants rs1049296 in the transferrin (TF) gene and rs1800562 in the homeostatic iron regulator (HFE) gene, commonly known as hemochromatosis, is in genetic association with AD.	Iron	148-152	transferrin	Homo sapiens	93-104
31931255-1	2020	The aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFalpha) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP).	Iron	105-107	interleukin 6	Rattus norvegicus	152-156
31931255-1	2020	The aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFalpha) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP).	Iron	105-107	tumor necrosis factor	Rattus norvegicus	158-166
32088595-1	2020	Trivalent chromium has been proposed to be transported in vivo from the bloodstream to the tissues via endocytosis by transferrin (Tf), the major iron transport protein in the blood.	Iron	146-150	transferrin	Homo sapiens	118-129
32088595-1	2020	Trivalent chromium has been proposed to be transported in vivo from the bloodstream to the tissues via endocytosis by transferrin (Tf), the major iron transport protein in the blood.	Iron	146-150	transferrin	Homo sapiens	131-133
32296847-7	2020	In particular, iron overload-related mitochondrial ferritin and nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) proteins were increased in the hippocampus of ob/ob.	Iron	15-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-107
32296847-7	2020	In particular, iron overload-related mitochondrial ferritin and nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) proteins were increased in the hippocampus of ob/ob.	Iron	15-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	109-113
32296847-7	2020	In particular, iron overload-related mitochondrial ferritin and nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) proteins were increased in the hippocampus of ob/ob.	Iron	15-19	heme oxygenase 1	Mus musculus	115-131
32296847-7	2020	In particular, iron overload-related mitochondrial ferritin and nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) proteins were increased in the hippocampus of ob/ob.	Iron	15-19	heme oxygenase 1	Mus musculus	133-137
32409289-4	2020	The starting thresholds for iron are for 78% of nephrologists a transferrin saturation <20% and for 80% a serum ferritin <100 mug/L.	Iron	28-32	transferrin	Homo sapiens	64-75
32409289-11	2020	However, they indicate a sub-prescription of iron compared to the European recommendations which recommend a starting threshold of iron of transferrin saturation <25% and ferritinemia <200 mug/L in anemic patients not treated with erythropoietin-stimulating agents.	Iron	131-135	transferrin	Homo sapiens	139-150
32143980-3	2020	Two of these studies suggest that an epistatic interaction between variants rs1049296 in the transferrin (TF) gene and rs1800562 in the homeostatic iron regulator (HFE) gene, commonly known as hemochromatosis, is in genetic association with AD.	Iron	148-152	transferrin	Homo sapiens	106-108
32143980-4	2020	TF and HFE are involved in the transport and regulation of iron in the brain, and disrupting these processes exacerbates AD pathology through increased neurodegeneration and oxidative stress.	Iron	59-63	transferrin	Homo sapiens	0-2
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	163-167	hepcidin antimicrobial peptide	Rattus norvegicus	88-96
32186328-5	2020	It was concluded that HGF protects PC12 cells against OGD/R-induced injury mainly by reducing cell iron contents via the up-regulation of Fpn1 and increased Fpn1-mediated iron export from cells.	Iron	171-175	solute carrier family 40 member 1	Rattus norvegicus	157-161
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	163-167	solute carrier family 40 member 1	Rattus norvegicus	182-195
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	229-233	hepcidin antimicrobial peptide	Rattus norvegicus	88-96
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	229-233	solute carrier family 40 member 1	Rattus norvegicus	182-195
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	229-233	solute carrier family 40 member 1	Rattus norvegicus	197-201
32577185-7	2020	Results: Serum iron were negatively correlated with BMI (P = 0.045, r = -0.154) and hs-CRP (P = 0.032, r = -0.165).	Iron	15-19	C-reactive protein	Homo sapiens	87-90
32391122-7	2020	NMR spectroscopy revealed that gallium binds to IscU, the bacterial scaffold protein for Fe-S cluster assembly and stabilizes its folded state.	Iron	89-91	iron-sulfur cluster assembly enzyme	Rattus norvegicus	48-52
32324886-6	2020	We show, for the first time, the importance of EPO-FGF23 signaling in hereditary hemolytic anemia: there was a clear correlation between total FGF23 and EPO levels (r = +0.64; 95% confidence interval [CI], 0.09-0.89), which persisted after adjustment for iron load, inflammation, and kidney function.	Iron	255-259	erythropoietin	Homo sapiens	47-50
32357481-1	2020	Insulin resistance and diabetes mellitus are common consequences of iron overload in the pancreas of beta-thalassemia major (BTM) patients.	Iron	68-72	insulin	Homo sapiens	0-7
32349426-8	2020	In IBDs and, in particular, in celiac disease (CeD), IL-6 might trigger the expression, upregulation and secretion of hepcidin in the small intestine, reducing iron efflux and exacerbating defective iron absorption.	Iron	160-164	interleukin 6	Homo sapiens	53-57
32349426-8	2020	In IBDs and, in particular, in celiac disease (CeD), IL-6 might trigger the expression, upregulation and secretion of hepcidin in the small intestine, reducing iron efflux and exacerbating defective iron absorption.	Iron	199-203	interleukin 6	Homo sapiens	53-57
32380365-7	2020	HIF-1a, as a crucial part of HIF-1, was also elevated in iron overload-group and PHD2 involved in the degradation of HIF-1a was reduced.	Iron	57-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
32380365-9	2020	When treated with DFO and NAC for iron chelation and antioxidation, the level of HIF-1a and related cytokines could decrease.	Iron	34-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-87
32380365-10	2020	We conclude that iron overload regulates the cytokine of mesenchymal stromal cells through ROS/HIF-1alpha pathway in Myelodysplastic syndromes, result in dysfunction of MSC and damage of microenvironment that may be involved in the pathogenesis of MDS.	Iron	17-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
32377332-3	2020	In addition, 2-oxoglutarate- (OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element binding protein 2 (IRP2) stability.	Iron	104-108	egl-9 family hypoxia inducible factor 1	Homo sapiens	69-73
32377332-3	2020	In addition, 2-oxoglutarate- (OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element binding protein 2 (IRP2) stability.	Iron	104-108	iron responsive element binding protein 2	Homo sapiens	123-164
32377332-3	2020	In addition, 2-oxoglutarate- (OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element binding protein 2 (IRP2) stability.	Iron	104-108	iron responsive element binding protein 2	Homo sapiens	166-170
32380365-0	2020	Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1alpha pathway in Myelodysplastic syndromes.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
32380365-6	2020	Iron transportation-related gene, such as DMT1 and ZIP14, and ROS level were increased in iron overload-MDS-MSC (n = 23).	Iron	0-4	charged multivesicular body protein 2B	Homo sapiens	42-46
32380365-6	2020	Iron transportation-related gene, such as DMT1 and ZIP14, and ROS level were increased in iron overload-MDS-MSC (n = 23).	Iron	90-94	charged multivesicular body protein 2B	Homo sapiens	42-46
32380365-7	2020	HIF-1a, as a crucial part of HIF-1, was also elevated in iron overload-group and PHD2 involved in the degradation of HIF-1a was reduced.	Iron	57-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-6
32341992-0	2020	Grab "n Go: Siderophore-Binding Proteins Provide Pathogens a Quick Fix to Satisfy Their Hunger for Iron.	Iron	99-103	RAB3A interacting protein like 1	Homo sapiens	0-4
32191033-4	2020	After exposure to Cig-WS and Wood-WS and the FA standards, iron was imported by respiratory epithelial cells reflecting a functional iron deficiency.	Iron	59-63	fibronectin 1	Homo sapiens	18-21
32191033-6	2020	Co-exposure of the respiratory epithelial cells with iron decreased supernatant concentrations of the ILs relative to exposures to Cig-WS, Wood-WS, SRFA and NFA alone.	Iron	53-57	fibronectin 1	Homo sapiens	131-134
32301986-0	2021	The problem with transferrin saturation as an indicator of iron "sufficiency" in chronic kidney disease.	Iron	59-63	transferrin	Homo sapiens	17-28
32316587-0	2020	Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent.	Iron	84-88	erythropoietin	Homo sapiens	36-50
32316587-4	2020	EPO, ERFE and Hpc biosynthesis is modified by serum iron through transferrin receptor 2.	Iron	52-56	erythropoietin	Homo sapiens	0-3
32316587-9	2020	In athletes whose serum iron levels were below 105 microg/day (n = 15), serum EPO (p = 0.00) and ERFE levels (p = 0.00) increased with no changes in Hpc concentration.	Iron	24-28	erythropoietin	Homo sapiens	78-81
32316587-12	2020	This indicates modulation of blood iron may affect exercise-induced changes in the EPO/ERFE/Hpc axis.	Iron	35-39	erythropoietin	Homo sapiens	83-86
32316587-13	2020	Further study is needed to fully understand the physiological meaning of the interdependence between iron and the EPO/ERFE/Hpc axis.	Iron	101-105	erythropoietin	Homo sapiens	114-117
32316589-0	2020	Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training.	Iron	0-4	myostatin	Homo sapiens	37-46
32316589-0	2020	Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training.	Iron	0-4	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-59
32316589-0	2020	Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training.	Iron	0-4	bone gamma-carboxyglutamate protein	Homo sapiens	64-75
32301986-5	2021	As a result, transferrin saturation (TSAT) becomes a poorer index of iron availability to the bone marrow and serum ferritin no longer represents iron that can be used during erythropoiesis.	Iron	69-73	transferrin	Homo sapiens	13-24
32328497-17	2020	The effect of the heme moiety as prosthetic group of aromatase further depends on the absorption of iron as a function of pH and redox state.	Iron	100-104	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	53-62
32115591-0	2020	A micellized fluorescence sensor based on amplified quenching for highly sensitive detection of non-transferrin-bound iron in serum.	Iron	118-122	transferrin	Homo sapiens	100-111
32115591-1	2020	A novel, micelle-based fluorescence system capable of selective and sensitive signal transduction for non-transferrin-bound iron (NTBI) in serum was devised.	Iron	124-128	transferrin	Homo sapiens	106-117
32302923-4	2020	We assessed the association of the inflammatory response, as evidenced by hsCRP and albumin, with iron status indicators by general linear regression analysis.	Iron	98-102	albumin	Homo sapiens	84-91
32017244-3	2020	[Cu L 2 ][BF 4 ] 2  2H 2 O and [Zn L 2 ][BF 4 ] 2  2H 2 O are not perfectly isostructural but, unlike the iron compound, they undergo single-crystal-to-single-crystal dehydration upon annealing.	Iron	106-110	cullin 2	Homo sapiens	1-7
32260496-0	2020	Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics.	Iron	51-55	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
32258529-10	2020	Atransferrinemia and DMT1 deficiency are characterized by iron deficient erythropoiesis, severe microcytic anemia with high transferrin saturation and parenchymal iron overload due to secondary hepcidin suppression.	Iron	58-62	transferrin	Homo sapiens	1-12
32260496-10	2020	The correlations of serum hepcidin and erythroferrone with liver DMT1 and TfR represent significant mechanisms of Fe homeostasis.	Iron	114-116	hepcidin antimicrobial peptide	Rattus norvegicus	26-34
32126207-0	2020	FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.	Iron	34-38	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
32167766-0	2020	C-O Bond Silylation Catalyzed by Iron: A General Method for the Construction of Csp2-Si Bonds.	Iron	33-37	regulator of calcineurin 2	Homo sapiens	80-84
32167766-1	2020	The iron-catalyzed construction of Csp2-Si bonds via unreactive C-O bonds possesses a challenging topic in organic chemistry.	Iron	4-8	regulator of calcineurin 2	Homo sapiens	35-39
32126207-0	2020	FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.	Iron	34-38	iron responsive element binding protein 2	Homo sapiens	16-20
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Iron	9-13	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
32243827-0	2020	How Oxidation of a Unique Iron-Sulfur Cluster in FBXL5 Regulates IRP2 Levels and Promotes Regulation of Iron Metabolism Proteins.	Iron	26-30	F-box and leucine rich repeat protein 5	Homo sapiens	49-54
32243827-0	2020	How Oxidation of a Unique Iron-Sulfur Cluster in FBXL5 Regulates IRP2 Levels and Promotes Regulation of Iron Metabolism Proteins.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	65-69
32126207-6	2020	Steric incompatibility also allows FBXL5 to physically dislodge IRP2 from iron-responsive element RNA to facilitate its turnover.	Iron	74-78	iron responsive element binding protein 2	Homo sapiens	64-68
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	72-97
32126207-7	2020	Taken together, our studies have identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations.	Iron	47-51	F-box and leucine rich repeat protein 5	Homo sapiens	74-79
32126207-7	2020	Taken together, our studies have identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations.	Iron	47-51	iron responsive element binding protein 2	Homo sapiens	96-100
32243827-0	2020	How Oxidation of a Unique Iron-Sulfur Cluster in FBXL5 Regulates IRP2 Levels and Promotes Regulation of Iron Metabolism Proteins.	Iron	104-108	F-box and leucine rich repeat protein 5	Homo sapiens	49-54
32243827-0	2020	How Oxidation of a Unique Iron-Sulfur Cluster in FBXL5 Regulates IRP2 Levels and Promotes Regulation of Iron Metabolism Proteins.	Iron	104-108	iron responsive element binding protein 2	Homo sapiens	65-69
32243827-2	2020	(2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes FBXL5 binding to IRP2 to effect its oxygen-dependent degradation, unveiling a novel and previously unrecognized mechanism involved in regulation of cellular iron homeostasis.	Iron	302-306	F-box and leucine rich repeat protein 5	Homo sapiens	64-69
32126207-7	2020	Taken together, our studies have identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations.	Iron	156-160	F-box and leucine rich repeat protein 5	Homo sapiens	74-79
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	99-103
32126207-7	2020	Taken together, our studies have identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations.	Iron	156-160	iron responsive element binding protein 2	Homo sapiens	96-100
32243827-2	2020	(2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes FBXL5 binding to IRP2 to effect its oxygen-dependent degradation, unveiling a novel and previously unrecognized mechanism involved in regulation of cellular iron homeostasis.	Iron	302-306	F-box and leucine rich repeat protein 5	Homo sapiens	145-150
32243827-2	2020	(2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes FBXL5 binding to IRP2 to effect its oxygen-dependent degradation, unveiling a novel and previously unrecognized mechanism involved in regulation of cellular iron homeostasis.	Iron	302-306	iron responsive element binding protein 2	Homo sapiens	162-166
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Iron	72-76	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
32126207-1	2020	Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen.	Iron	72-76	iron responsive element binding protein 2	Homo sapiens	99-103
32126207-6	2020	Steric incompatibility also allows FBXL5 to physically dislodge IRP2 from iron-responsive element RNA to facilitate its turnover.	Iron	74-78	F-box and leucine rich repeat protein 5	Homo sapiens	35-40
32035059-2	2020	In this study, we hypothesized that heme oxygenase-1 (HO-1), an enzyme responsible for degradation of heme to carbon monoxide (CO), bilirubin, and iron is an important regulator of inflammation and epithelial responses in the prostate.	Iron	147-151	heme oxygenase 1	Mus musculus	36-52
31697569-10	2020	FENDRR was preferentially localized in the cytoplasm of adult lung fibroblasts and bound IRP1, suggesting its role in iron metabolism.	Iron	118-122	Foxf1 adjacent non-coding developmental regulatory RNA	Mus musculus	0-6
31697569-11	2020	FENDRR reduced pulmonary fibrosis by inhibiting fibroblast activation by reducing iron level and acting as a competing endogenous RNA of the profibrotic miR-214.	Iron	82-86	Foxf1 adjacent non-coding developmental regulatory RNA	Mus musculus	0-6
32035059-2	2020	In this study, we hypothesized that heme oxygenase-1 (HO-1), an enzyme responsible for degradation of heme to carbon monoxide (CO), bilirubin, and iron is an important regulator of inflammation and epithelial responses in the prostate.	Iron	147-151	heme oxygenase 1	Mus musculus	54-58
32048444-13	2020	DISCUSSION: Oral iron therapy is effective and safe in EPO-free patients with normal hepcidin levels.	Iron	17-21	erythropoietin	Homo sapiens	55-58
31927189-4	2020	The approach was based on direct binding of CEA to a fixed amount of anti-CEA on the modified electrode for the specific detection using linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) monitored in a solution containing 5 mM [Fe(CN)63-/4-] prepared in 0.1 M phosphate buffer at pH 7.4.	Iron	258-260	CEA cell adhesion molecule 3	Homo sapiens	44-47
31927189-4	2020	The approach was based on direct binding of CEA to a fixed amount of anti-CEA on the modified electrode for the specific detection using linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) monitored in a solution containing 5 mM [Fe(CN)63-/4-] prepared in 0.1 M phosphate buffer at pH 7.4.	Iron	258-260	CEA cell adhesion molecule 3	Homo sapiens	74-77
31892506-7	2020	Serum markers of iron metabolism increased significantly compared to baseline, as disease activity measured by C-reactive protein (CRP) was reduced.	Iron	17-21	C-reactive protein	Homo sapiens	131-134
32048444-15	2020	HD patients treated with rHU-EPO and with normal hepcidin levels could benefit from oral iron treatment.	Iron	89-93	erythropoietin	Homo sapiens	29-32
31614076-7	2020	Values of the dissociation equilibrium constant for neonicotinoid binding FA1 of HSA (i.e., calc Kn ) derived from in silico docking simulations (ranging between 3.9 x 10-5 and 6.3 x 10-4 M) agree with those determined experimentally from competitive inhibition of heme-Fe(III) binding (i.e., exp Kn ; ranging between 2.1 x 10-5 and 6.9 x 10-5 M).	Iron	270-277	albumin	Homo sapiens	81-84
32244772-8	2020	To predict the accessibility of substrate atoms to the heme iron, conventional protein-rigid docking methods failed due to the high flexibility of the CYP3A4 protein.	Iron	60-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-157
32131593-3	2020	In the ISC pathway, the pyridoxal 5"-phosphate-dependent cysteine desulfurase enzyme IscS provides sulfur to the scaffold protein IscU, which templates the Fe-S cluster assembly.	Iron	156-160	iron-sulfur cluster assembly enzyme	Homo sapiens	130-134
32241053-2	2020	Timely diagnosis and treatment of iron deficiency anemia in the perioperative period will improve the clinical outcome of patients and reduce the medical burden.Management of perioperative iron deficiency anemia includes familiar with the diagnosis and grading of anemia, monitoring patient"s hemoglobin, treatment of anemic etiology, nutritional support, iron supplementation, implementation of restrictive transfusion strategy, application of erythropoietin, autotransfusion, etc.Multidisciplinary management of iron deficiency anemia is encouraged.	Iron	34-38	erythropoietin	Homo sapiens	445-459
32244712-1	2020	During human pregnancy, iron requirements gradually increase, leading to higher amounts of erythropoietin (EPO) and reticulocytes, and changes in erythrocyte size and density.	Iron	24-28	erythropoietin	Homo sapiens	91-105
32244712-1	2020	During human pregnancy, iron requirements gradually increase, leading to higher amounts of erythropoietin (EPO) and reticulocytes, and changes in erythrocyte size and density.	Iron	24-28	erythropoietin	Homo sapiens	107-110
32244712-3	2020	In this study we aimed to describe the relationship between EPO and iron nutrition status during nonanemic pregnancy, and to explore whether obesity and inflammation influence erythropoiesis and red cell indices.	Iron	68-72	erythropoietin	Homo sapiens	60-63
31721347-1	2020	FRD3 (FERRIC REDUCTASE DEFECTIVE 3) plays a major role in iron (Fe) and zinc (Zn) homeostasis in Arabidopsis.	Iron	58-62	MATE efflux family protein	Arabidopsis thaliana	0-4
31721347-1	2020	FRD3 (FERRIC REDUCTASE DEFECTIVE 3) plays a major role in iron (Fe) and zinc (Zn) homeostasis in Arabidopsis.	Iron	58-62	MATE efflux family protein	Arabidopsis thaliana	6-34
31721347-1	2020	FRD3 (FERRIC REDUCTASE DEFECTIVE 3) plays a major role in iron (Fe) and zinc (Zn) homeostasis in Arabidopsis.	Iron	64-66	MATE efflux family protein	Arabidopsis thaliana	0-4
31721347-1	2020	FRD3 (FERRIC REDUCTASE DEFECTIVE 3) plays a major role in iron (Fe) and zinc (Zn) homeostasis in Arabidopsis.	Iron	64-66	MATE efflux family protein	Arabidopsis thaliana	6-34
32004914-5	2020	In this study NO3- was added to supplement the insufficient NOx- to enhance Fe(III) regeneration and remove nitrogen successively.	Iron	76-83	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
32004914-8	2020	Adding NO3- in the digester to trigger Fe(III)/Fe(II) cycle for removing ammonium is just equivalent to an anammox-like process using NO3- as terminal electron acceptor to oxidize NH4+.	Iron	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
32004914-8	2020	Adding NO3- in the digester to trigger Fe(III)/Fe(II) cycle for removing ammonium is just equivalent to an anammox-like process using NO3- as terminal electron acceptor to oxidize NH4+.	Iron	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
32004914-8	2020	Adding NO3- in the digester to trigger Fe(III)/Fe(II) cycle for removing ammonium is just equivalent to an anammox-like process using NO3- as terminal electron acceptor to oxidize NH4+.	Iron	47-53	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
32004914-8	2020	Adding NO3- in the digester to trigger Fe(III)/Fe(II) cycle for removing ammonium is just equivalent to an anammox-like process using NO3- as terminal electron acceptor to oxidize NH4+.	Iron	47-53	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
31883180-13	2020	The present results provide in vivo and in vitro evidence that microglial glutamate release in SALS spinal cords is enhanced by intracellular soluble iron accumulation-induced activation of ACO1 and TACE and by increased extracellular TNFalpha-stimulated GLS-C upregulation, and suggest a positive feedback mechanism to maintain increased intracellular soluble iron levels, involving TNFalpha, hepcidin, and FPN.	Iron	150-154	a disintegrin and metallopeptidase domain 17	Mus musculus	199-203
31883180-13	2020	The present results provide in vivo and in vitro evidence that microglial glutamate release in SALS spinal cords is enhanced by intracellular soluble iron accumulation-induced activation of ACO1 and TACE and by increased extracellular TNFalpha-stimulated GLS-C upregulation, and suggest a positive feedback mechanism to maintain increased intracellular soluble iron levels, involving TNFalpha, hepcidin, and FPN.	Iron	150-154	tumor necrosis factor	Mus musculus	384-392
31883180-13	2020	The present results provide in vivo and in vitro evidence that microglial glutamate release in SALS spinal cords is enhanced by intracellular soluble iron accumulation-induced activation of ACO1 and TACE and by increased extracellular TNFalpha-stimulated GLS-C upregulation, and suggest a positive feedback mechanism to maintain increased intracellular soluble iron levels, involving TNFalpha, hepcidin, and FPN.	Iron	361-365	tumor necrosis factor	Mus musculus	235-243
32218586-10	2020	In conclusion, split application of Fe at 15 kg ha-1 seemed a viable technique to enhance yield, economic returns, grain-Fe concentration and bioavailability of mungbean.	Iron	36-38	Rho GTPase activating protein 45	Homo sapiens	48-52
32188787-6	2020	Next, we show that the iron transporter Tsf1 is induced by infections downstream of the Toll and Imd pathways and is necessary for iron relocation from the hemolymph to the fat body.	Iron	23-27	immune deficiency	Drosophila melanogaster	97-100
32292401-10	2020	Metabolomic analysis confirmed that Treml4 deficiency may promote a beneficial relationship between iron homeostasis and glucose metabolism.	Iron	100-104	triggering receptor expressed on myeloid cells-like 4	Mus musculus	36-42
32212927-1	2021	Transferrin is a protein involved in iron uptake by cells and has been identified as a potential target for directing drug-loaded nanoparticles for cancer treatment and diagnosis.	Iron	37-41	transferrin	Homo sapiens	0-11
32734254-4	2020	The current evidence base, including data from a recent randomized controlled trial, suggests that proactive judicious use of intravenous iron (in a manner that minimizes the accumulation of non-transferrin-bound iron) beneficially replaces iron stores while avoiding a clinically relevant effect on infection risk.	Iron	138-142	transferrin	Homo sapiens	195-206
31787315-1	2020	In East and Southeast Asia, the health of over 100 million people is threatened by the consumption of groundwater containing high concentrations of arsenic (>10 mug L-1), which is released from sediments through reductive dissolution of arsenic-bearing iron/manganese oxides.	Iron	253-257	L1 cell adhesion molecule	Homo sapiens	165-168
32043994-10	2020	The presence of iron (0-1 mg L-1) caused a decrease in the diffusion coefficients, but with regard to the common concentrations of iron (less than 0.3 mg L-1), the negative effect was considered not significant for AsIII and DMA in natural water.	Iron	16-20	immunoglobulin kappa variable 1-16	Homo sapiens	29-32
32209682-3	2020	Here, we dissected a regulatory network directed by the conserved iron homeostasis regulator, ferric uptake regulator (Fur), in uropathogenic E. coli (UPEC) strain CFT073.	Iron	66-70	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	119-122
32209682-7	2020	In addition, iron chelation increased RpoS to the same levels as in the fur mutant.	Iron	13-17	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	72-75
32209682-10	2020	We compared the regulatory network controlled by Fur in uropathogenic E. coli (UPEC) to that of nonpathogenic E. coli K-12 to uncover strategies that pathogenic bacteria use to overcome iron limitation.	Iron	186-190	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	49-52
32209682-11	2020	Although iron homeostasis functions were regulated by Fur in the uropathogen as expected, a surprising finding was the activation of the stringent and general stress responses in the uropathogen fur mutant, which was rescued by amino acid addition.	Iron	9-13	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	54-57
32209682-11	2020	Although iron homeostasis functions were regulated by Fur in the uropathogen as expected, a surprising finding was the activation of the stringent and general stress responses in the uropathogen fur mutant, which was rescued by amino acid addition.	Iron	9-13	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	195-198
32235809-6	2020	Immunohistochemical staining showed that >1 g of ferric iron increased iron and AGE retention in testicular interstitial tissues, which is associated with increased expression of the receptor for AGEs (RAGE), tumor necrosis factor-alpha, and nitric oxide.	Iron	56-60	tumor necrosis factor	Homo sapiens	209-236
32244917-1	2020	It is well known that axial coordination of heme iron in mitochondrial cytochrome c has redox-dependent stability.	Iron	49-53	cytochrome c, somatic	Homo sapiens	71-83
32193389-0	2020	Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.	Iron	58-62	tumor protein p53	Homo sapiens	35-39
31796279-5	2020	Results suggested that all metal ions at their critical concentrations caused severe flux decline; Cu2+ at a very low concentration of 5 muM, Al3+ and Fe3+ at 20 muM.	Iron	151-155	latexin	Homo sapiens	162-165
32183063-4	2020	We summarize evidence of the potential therapeutic effect of iron chelation in retinal diseases and especially the interest of transferrin, a ubiquitous endogenous iron-binding protein, having the ability to treat or delay degenerative retinal diseases.	Iron	164-168	transferrin	Homo sapiens	127-138
31855815-7	2020	We have demonstrated that the method using the carbon dots for Fe3+ ions detection was rapid, reliable, and selective with a detection limit as low as 0.720 muM and a dynamic range from 5.0 to 500.0 muM.	Iron	63-67	latexin	Homo sapiens	157-160
31855815-7	2020	We have demonstrated that the method using the carbon dots for Fe3+ ions detection was rapid, reliable, and selective with a detection limit as low as 0.720 muM and a dynamic range from 5.0 to 500.0 muM.	Iron	63-67	latexin	Homo sapiens	199-202
32152190-15	2021	However, iron studies showed low serum iron and transferrin saturation.	Iron	9-13	transferrin	Homo sapiens	48-59
32123892-2	2020	It was found that Fe atoms were strongly anchored at the sp-C vacancy site of alpha-graphyne with a large binding energy of -5.28 eV and effectively adsorbed and activated O2 molecules.	Iron	18-20	surfactant protein C	Homo sapiens	57-61
32182331-12	2020	Conclusions: The above observations suggest that TGF-beta2 and hepcidin form a self-sustained feed-forward loop through iron-catalyzed ROS.	Iron	120-124	transforming growth factor beta 2	Bos taurus	49-58
32182331-13	2020	This loop is partially disrupted by a hepcidin antagonist and an anti-oxidant, implicating iron and ROS in TGF-beta2-mediated POAG.	Iron	91-95	transforming growth factor beta 2	Bos taurus	107-116
31990092-2	2020	Herein, an unexpected reverse effect is observed for the first time in the S = 1/2 {Fe II LS - Co III LS - Fe III LS } (HS = high spin, LS = low spin) ground state of a novel V-shaped trinuclear cyanide-bridged {Fe 2 Co} complex.	Iron	84-89	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	95-101
31990092-2	2020	Herein, an unexpected reverse effect is observed for the first time in the S = 1/2 {Fe II LS - Co III LS - Fe III LS } (HS = high spin, LS = low spin) ground state of a novel V-shaped trinuclear cyanide-bridged {Fe 2 Co} complex.	Iron	107-113	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	95-101
31990092-2	2020	Herein, an unexpected reverse effect is observed for the first time in the S = 1/2 {Fe II LS - Co III LS - Fe III LS } (HS = high spin, LS = low spin) ground state of a novel V-shaped trinuclear cyanide-bridged {Fe 2 Co} complex.	Iron	84-86	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	95-101
32210768-10	2020	The iron chelator desferrioxamine (DFO, 100 mumol/L) exerted suppressive effects on TNF-alpha mRNA levels, although no change was observed for TNF-alpha release.	Iron	4-8	tumor necrosis factor	Homo sapiens	84-93
32179400-3	2020	The effluent TN concentration was 8.35 +- 1.94 mg/L in iron-MEC when the conductivity of the wastewater was adjusted to 3.97 +- 0.08 mS/cm, which was lower than that in no-treated reactor.	Iron	55-59	C-C motif chemokine ligand 28	Homo sapiens	60-63
32155778-1	2020	A large body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with amyloid precursor protein (APP) and Abeta amyloid may contribute to the Alzheimer"s disease (AD) Abeta amyloid pathology.	Iron	77-79	amyloid beta precursor protein	Homo sapiens	117-142
32151055-1	2020	Chemically crosslinked hydrogel magnetorheological (MR) plastomer (MRP) embedded with carbonyl iron particles (CIPs) exhibits excellent magnetic performance (MR effect) in the presence of external stimuli especially magnetic field.	Iron	95-99	ATP binding cassette subfamily C member 1	Homo sapiens	67-70
32179400-7	2020	The enrichment of Geobacter in iron-MEC might imply that the part of Fe(III) produced by ferrous oxidation was reduced by Geobacter, which established an iron cycle.	Iron	31-35	C-C motif chemokine ligand 28	Homo sapiens	36-39
32057236-4	2020	We report here the structural and redox properties of a thiolate-based dinuclear Fe complex, [FeII2(LS)2] (LS2- = 2,2"-(2,2"-bipyridine-6,6"-iyl)bis(1,1-diphenylethanethiolate)), and its reactivity with dioxygen, in comparison with its previously reported protonated counterpart, [FeII2(LS)(LSH)]+.	Iron	81-83	helicase, lymphoid specific	Homo sapiens	291-294
31813731-0	2020	Probing the interaction of iron complex containing N3S2 macrocyclic ligand with bovine serum albumin using spectroscopic techniques.	Iron	27-31	albumin	Homo sapiens	87-100
32420530-3	2020	Here we examined mitophagy that is induced upon iron chelation and found that the transcriptional activity of HIF1alpha, in part through upregulation of BNIP3 and NIX, is an essential mediator of this pathway in SH-SY5Y cells.	Iron	48-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-119
32420530-3	2020	Here we examined mitophagy that is induced upon iron chelation and found that the transcriptional activity of HIF1alpha, in part through upregulation of BNIP3 and NIX, is an essential mediator of this pathway in SH-SY5Y cells.	Iron	48-52	BCL2 interacting protein 3	Homo sapiens	153-158
31718975-1	2020	We developed PIM, a pyrene-based fluorescence sensor bearing an imidazole moiety and a carbonyl group as the binding sites for Fe3+ ions.	Iron	127-131	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-16
31718975-7	2020	Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM.	Iron	21-25	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	17-20
31718975-7	2020	Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM.	Iron	21-25	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	167-170
31718975-7	2020	Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM.	Iron	118-122	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	17-20
31718975-7	2020	Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM.	Iron	118-122	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	167-170
31718975-8	2020	The sequential detection of Fe3+ and His exhibited on-off-on phenomenon, and the Fe3+ and His detection limits were 0.11 and 3.06 muM, respectively.	Iron	81-85	latexin	Homo sapiens	130-133
32073839-2	2020	Interestingly, the sensing investigations suggest that JXUST-2 could be considered as a multifunctional fluorescence sensor toward Fe3+, Cr3+, and Al3+ via a turn-on effect with good reusability and detection limits of 0.13, 0.10, and 0.10 muM, respectively.	Iron	131-135	latexin	Homo sapiens	240-243
32057236-4	2020	We report here the structural and redox properties of a thiolate-based dinuclear Fe complex, [FeII2(LS)2] (LS2- = 2,2"-(2,2"-bipyridine-6,6"-iyl)bis(1,1-diphenylethanethiolate)), and its reactivity with dioxygen, in comparison with its previously reported protonated counterpart, [FeII2(LS)(LSH)]+.	Iron	94-99	helicase, lymphoid specific	Homo sapiens	291-294
32057236-5	2020	When reaction with O2 occurs in the absence of protons or in the presence of 1 equiv of proton (i.e., from [FeII2(LS)(LSH)]+), unsupported mu-oxo or mu-hydroxo FeIII dinuclear complexes ([FeIII2(LS)2O] and [FeIII2(LS)2(OH)]+, respectively) are generated.	Iron	108-113	helicase, lymphoid specific	Homo sapiens	118-121
31682896-6	2020	The iron transport across BBB is studied by considering both Lf- and Tf-mediated pathways for both normal and pathologic conditions.	Iron	4-8	transferrin	Homo sapiens	69-71
32006153-0	2020	M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload.	Iron	73-77	GLI family zinc finger 2	Homo sapiens	24-29
32006153-13	2020	Taken together, we demonstrated that THP-1-derived macrophages polarized to a phenotype of M2-like characteristics when subjected to chronic iron overload.	Iron	141-145	GLI family zinc finger 2	Homo sapiens	37-42
30851431-2	2020	These drugs and agrochemicals contain an imidazole, triazole or tetrazole substituent, with one of the nitrogens in the azole ring coordinating as the sixth axial ligand to the LDM heme iron.	Iron	186-190	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	177-180
31985531-6	2020	Among iron parameters, baseline transferrin was the best predictor of 28-day (area under the receiver operated characteristic 0.72 [95% confidence interval 0.67-0.78]) and 90-day survival (area under the receiver operated characteristic 0.65 [0.61-0.70]).	Iron	6-10	transferrin	Homo sapiens	32-43
31932862-6	2020	The linear range for determination of total iron in terms of Fe3+ was 50-900 mug L-1 with a limit of determination (LOD) of 20 mug L-1 and coefficient of variation (CV) of 3.2%.	Iron	44-48	immunoglobulin kappa variable 1-16	Homo sapiens	81-84
31932862-6	2020	The linear range for determination of total iron in terms of Fe3+ was 50-900 mug L-1 with a limit of determination (LOD) of 20 mug L-1 and coefficient of variation (CV) of 3.2%.	Iron	44-48	immunoglobulin kappa variable 1-16	Homo sapiens	131-134
31932862-6	2020	The linear range for determination of total iron in terms of Fe3+ was 50-900 mug L-1 with a limit of determination (LOD) of 20 mug L-1 and coefficient of variation (CV) of 3.2%.	Iron	61-65	immunoglobulin kappa variable 1-16	Homo sapiens	81-84
31987139-6	2020	The achieved limit of detection for determination of Fe(II), in the ten-pass configuration, was 0.4 mugL-1, with a relative standard deviation around 4.5%, which compares favorably with previously reported results for TLS determination of Fe(II) in thin samples using low excitation power.	Iron	53-59	FUS RNA binding protein	Homo sapiens	218-221
31987139-6	2020	The achieved limit of detection for determination of Fe(II), in the ten-pass configuration, was 0.4 mugL-1, with a relative standard deviation around 4.5%, which compares favorably with previously reported results for TLS determination of Fe(II) in thin samples using low excitation power.	Iron	239-245	FUS RNA binding protein	Homo sapiens	218-221
31839625-10	2020	Dex regulates iron metabolism by regulating iron importers and exporters through JNK/Sp1 and Stat4/Sp1 signaling.	Iron	14-18	mitogen-activated protein kinase 8	Homo sapiens	81-84
31236816-7	2020	After 7 weeks, compared with the control group, the zinc and magnesium contents; superoxide dismutase, glutathione peroxidase, and catalase activities; and synaptophysin and Bcl-2 gene expressions in the iron overload group were significantly decreased, whereas the iron, calcium contents, and malondialdehyde contents; TUNEL-positive cell numbers; and Fas and Bax gene expressions were significantly increased.	Iron	204-208	catalase	Rattus norvegicus	131-139
31236816-7	2020	After 7 weeks, compared with the control group, the zinc and magnesium contents; superoxide dismutase, glutathione peroxidase, and catalase activities; and synaptophysin and Bcl-2 gene expressions in the iron overload group were significantly decreased, whereas the iron, calcium contents, and malondialdehyde contents; TUNEL-positive cell numbers; and Fas and Bax gene expressions were significantly increased.	Iron	204-208	BCL2, apoptosis regulator	Rattus norvegicus	174-179
31839625-10	2020	Dex regulates iron metabolism by regulating iron importers and exporters through JNK/Sp1 and Stat4/Sp1 signaling.	Iron	44-48	mitogen-activated protein kinase 8	Homo sapiens	81-84
30981629-3	2020	We aimed to determine the difference of transferrin saturation between the treatment groups 8-12 weeks iron administration besides other parameters of iron status and blood count.	Iron	103-107	transferrin	Homo sapiens	40-51
31705542-0	2020	Angiotensin II receptor type 1 blockade prevents arterial remodeling and stiffening in iron overloaded rats.	Iron	87-91	angiotensin II receptor, type 1b	Rattus norvegicus	0-30
31705542-2	2020	We previously demonstrated that in vitro blockade of the angiotensin II type 1 receptor (AT1R) reversed functional vascular changes induced by chronic iron overload.	Iron	151-155	angiotensin II receptor, type 1b	Rattus norvegicus	57-87
31705542-2	2020	We previously demonstrated that in vitro blockade of the angiotensin II type 1 receptor (AT1R) reversed functional vascular changes induced by chronic iron overload.	Iron	151-155	angiotensin II receptor, type 1b	Rattus norvegicus	89-93
31705542-3	2020	In this study, the effect of chronic AT1R blocker on aorta stiffening was test in iron overloaded rats.	Iron	82-86	angiotensin II receptor, type 1b	Rattus norvegicus	37-41
31896184-7	2020	Moreover, Co3Fe7-CoFe2O4 showed efficient catalytic performance in continuous five runs and exhibited less metal leaching of 0.052 and 0.036 mg L-1 for Co and Fe species, respectively.	Iron	10-24	L1 cell adhesion molecule	Homo sapiens	144-147
31896184-7	2020	Moreover, Co3Fe7-CoFe2O4 showed efficient catalytic performance in continuous five runs and exhibited less metal leaching of 0.052 and 0.036 mg L-1 for Co and Fe species, respectively.	Iron	13-15	L1 cell adhesion molecule	Homo sapiens	144-147
32160771-7	2020	Mechanistically, we identified Glrx5 (glutaredoxin 5), a critical regulator of mitochondrial iron homeostasis and iron-sulfur cluster synthesis, as a direct miR-152 target.	Iron	93-97	glutaredoxin 5	Mus musculus	31-36
32160771-7	2020	Mechanistically, we identified Glrx5 (glutaredoxin 5), a critical regulator of mitochondrial iron homeostasis and iron-sulfur cluster synthesis, as a direct miR-152 target.	Iron	93-97	glutaredoxin 5	Mus musculus	38-52
32160771-7	2020	Mechanistically, we identified Glrx5 (glutaredoxin 5), a critical regulator of mitochondrial iron homeostasis and iron-sulfur cluster synthesis, as a direct miR-152 target.	Iron	114-118	glutaredoxin 5	Mus musculus	31-36
32160771-7	2020	Mechanistically, we identified Glrx5 (glutaredoxin 5), a critical regulator of mitochondrial iron homeostasis and iron-sulfur cluster synthesis, as a direct miR-152 target.	Iron	114-118	glutaredoxin 5	Mus musculus	38-52
31536831-1	2020	Neurodegeneration with brain iron accumulation (NBIA) comprises a group of rare genetic disorders characterized by progressive extrapyramidal and other neurological symptoms due to focal iron accumulation in the basal ganglia.1 beta-Propeller protein-associated neurodegeneration (BPAN) is the most recently identified subtype of NBIA caused by heterozygous variants in WDR45 (OMIM: *300526) at Xp11.23.	Iron	187-191	WD repeat domain 45	Homo sapiens	370-375
31536831-1	2020	Neurodegeneration with brain iron accumulation (NBIA) comprises a group of rare genetic disorders characterized by progressive extrapyramidal and other neurological symptoms due to focal iron accumulation in the basal ganglia.1 beta-Propeller protein-associated neurodegeneration (BPAN) is the most recently identified subtype of NBIA caused by heterozygous variants in WDR45 (OMIM: *300526) at Xp11.23.	Iron	29-33	WD repeat domain 45	Homo sapiens	370-375
31882562-4	2020	Mitochondrial ferritin (FtMT) is a mitochondrial matrix protein that chelates iron.	Iron	78-82	ferritin mitochondrial	Mus musculus	24-28
31949029-10	2020	Localized iron accumulation and callose deposition in the root elongation zone under Pi deficiency increased with LAC2-dependent lignification, suggesting a direct relationship between these processes.	Iron	10-14	laccase 2	Arabidopsis thaliana	114-118
31250406-6	2020	The current review summarizes recent findings on the possible role of SELENOP in AD, with a focus on probable mechanisms: Se delivery to neurons, antioxidant activity, cytoskeleton assembly, interaction with redox-active metals (e.g., copper and iron), and misfolded proteins (amyloid beta and tau protein).	Iron	246-250	selenoprotein P	Homo sapiens	70-77
31415112-7	2020	Our results also demonstrate that iron and/or galactose can modulate the observed glycosylation defects in TMEM165 KO cells.	Iron	34-38	transmembrane protein 165	Homo sapiens	107-114
31659405-2	2020	MT-2 decreases the production of hepcidin, a key regulator of iron homeostasis.	Iron	62-66	transmembrane serine protease 6	Homo sapiens	0-4
30898045-2	2020	Clinically significant human transferrin (hTf) is a key player involved in iron metabolism.	Iron	75-79	transferrin	Homo sapiens	29-40
32020293-8	2020	Therefore, in Cyt with C2 and C3, less intensive reduction of hem iron leaves more unoccupied target residues for Ru coordination, leading to more efficient formation of covalent adducts, in comparison to C1 and C4.	Iron	66-70	cytochrome c, somatic	Homo sapiens	14-17
31945260-1	2020	SCOPE: Iron plays an important role in the pathogenesis of insulin resistance (IR) and type 2 diabetes.	Iron	7-11	insulin	Homo sapiens	59-66
31945260-9	2020	CONCLUSIONS: The positive associations between these lipid species and ferritin or the ferritin/adiponectin ratio suggest a potential cross-talk between iron and lipid metabolism in obesity and IR.	Iron	153-157	adiponectin, C1Q and collagen domain containing	Homo sapiens	96-107
31199541-6	2020	Transitioning the Galt WWTP from Al to Fe dosing for P control had no significant impact on effluent P concentrations and resulted in a substantial reduction in the biogas H2 S concentration.	Iron	39-41	galactose-1-phosphate uridylyltransferase	Homo sapiens	18-22
32121273-2	2020	The hallmark of this regulated cell death is the presence of iron-driven lipid peroxidation; the activation of key genes related to this process such as glutathione peroxidase-4 (gpx4), acyl-CoA synthetase long-chain family member-4 (acsl4), carbonyl reductase [NADPH] 3 (cbr3), and prostaglandin peroxidase synthase-2 (ptgs2); and morphological changes including shrunken and electron-dense mitochondria.	Iron	61-65	acyl-CoA synthetase long chain family member 4	Homo sapiens	186-232
32121405-1	2020	Angiotensin II (Ang II) induces deleterious changes in cellular iron metabolism and increases the generation of reactive oxygen species.	Iron	64-68	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	16-22
32121405-3	2020	However, the mechanism underpinning Ang II-induced changes in iron metabolism is not known.	Iron	62-66	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	36-42
32121405-4	2020	We hypothesized that Ang II-induced ferritin degradation and an increase in the labile iron pool are mediated by the c-Jun N-terminal kinase (JNK)/p66Shc/ITCH signaling pathway.	Iron	87-91	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	21-27
32121405-10	2020	These observations suggest that Ang II-induced ferritin degradation and, hence, elevation of the levels of highly reactive iron, are mediated by the JNK/p66Shc/ITCH signaling pathway.	Iron	123-127	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	32-38
32121273-2	2020	The hallmark of this regulated cell death is the presence of iron-driven lipid peroxidation; the activation of key genes related to this process such as glutathione peroxidase-4 (gpx4), acyl-CoA synthetase long-chain family member-4 (acsl4), carbonyl reductase [NADPH] 3 (cbr3), and prostaglandin peroxidase synthase-2 (ptgs2); and morphological changes including shrunken and electron-dense mitochondria.	Iron	61-65	acyl-CoA synthetase long chain family member 4	Homo sapiens	234-239
31757562-4	2020	When BLM exists, BLM with Fe2+ as irreversible cofactor can specifically recognize and cleave of the 5"-GC-3" active site of DNA2, resulting in reduced precipitation deposited on the electrode and recovery of PEC signal.	Iron	26-30	DNA replication helicase/nuclease 2	Homo sapiens	125-129
32158699-4	2020	In this study, we found that the crp gene was involved in growth rate, biofilm formation, stress tolerance, serum resistance, and iron utilization.	Iron	130-134	C-reactive protein	Sus scrofa	33-36
31899794-4	2020	Here we developed antibodies against ERFE to prevent hepcidin suppression and correct the iron loading phenotype in a mouse model of beta-thalassemia (Hbb(th3/+) mice) and used these antibodies as tools to further characterize ERFE"s mechanism of action.	Iron	90-94	erythroferrone	Mus musculus	37-41
31899794-8	2020	Finally, we observed a decrease in splenomegaly and serum and liver iron in anti-ERFE treated Hbb(th3/+) mice, accompanied by an increase in red blood cells and hemoglobin and decrease in reticulocyte counts.	Iron	68-72	erythroferrone	Mus musculus	81-85
31899794-9	2020	In summary, we demonstrate that ERFE binds BMP6 directly and with high affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interactions constitute a potential therapeutic tool for iron-loading anemias.	Iron	221-225	erythroferrone	Mus musculus	32-36
31899794-9	2020	In summary, we demonstrate that ERFE binds BMP6 directly and with high affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interactions constitute a potential therapeutic tool for iron-loading anemias.	Iron	221-225	erythroferrone	Mus musculus	136-140
31899794-9	2020	In summary, we demonstrate that ERFE binds BMP6 directly and with high affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interactions constitute a potential therapeutic tool for iron-loading anemias.	Iron	221-225	erythroferrone	Mus musculus	136-140
32017541-0	2020	Bioinspired CNP Iron(II) Pincers Relevant to [Fe]-Hydrogenase (Hmd): Effect of Dicarbonyl versus Monocarbonyl Motifs in H2 Activation and Transfer Hydrogenation.	Iron	16-24	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	12-15
32017541-0	2020	Bioinspired CNP Iron(II) Pincers Relevant to [Fe]-Hydrogenase (Hmd): Effect of Dicarbonyl versus Monocarbonyl Motifs in H2 Activation and Transfer Hydrogenation.	Iron	46-48	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	12-15
32017541-1	2020	A set of bioinspired carbamoyl CNP pincer complexes are reported that are relevant to [Fe]-hydrogenase (Hmd).	Iron	87-89	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	31-34
31904058-4	2020	Using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), our results revealed an age-dependent increase in brain iron levels in both WT and rTg(tauP301L)4510 mice.	Iron	135-139	thyroglobulin	Rattus norvegicus	162-165
32079434-9	2022	Serum hepcidin, transferrin saturationand MDA/FRAP ratio is useful in differentiating pre-eclampsia patients from healthy pregnant women.Conclusion: Iron supplementation in preeclampsia patients might have led to a state of iron overload, which might have caused oxidative stress and endothelial dysfunction in preeclampsia patients.	Iron	149-153	transferrin	Homo sapiens	16-27
32079434-9	2022	Serum hepcidin, transferrin saturationand MDA/FRAP ratio is useful in differentiating pre-eclampsia patients from healthy pregnant women.Conclusion: Iron supplementation in preeclampsia patients might have led to a state of iron overload, which might have caused oxidative stress and endothelial dysfunction in preeclampsia patients.	Iron	149-153	mechanistic target of rapamycin kinase	Homo sapiens	46-50
32085508-0	2020	Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Activation.	Iron	0-4	Sp2 transcription factor	Homo sapiens	15-20
32085508-3	2020	Applying an in situ catalyst activation method using air-stable and easily handed reagents, the iron-catalysed C(sp2)-H borylation reactions of furans and thiophenes under blue light irradiation have been developed.	Iron	96-100	Sp2 transcription factor	Homo sapiens	111-116
31733190-7	2020	NUBP2 is implicated in both the cytosolic iron/sulfur cluster assembly pathway and negative regulation of ciliogenesis.	Iron	42-46	nucleotide binding protein 2	Mus musculus	0-5
31740260-1	2020	We develop a low-background electrochemical biosensor for one-step detection of uracil DNA glycosylase (UDG) based on the host-guest interaction and iron-embedded nitrogen-rich carbon nanotube (Fe-N-C) that mimics enzyme-mediated electrocatalysis to achieve signal amplification.	Iron	149-153	uracil DNA glycosylase	Homo sapiens	80-102
31740260-1	2020	We develop a low-background electrochemical biosensor for one-step detection of uracil DNA glycosylase (UDG) based on the host-guest interaction and iron-embedded nitrogen-rich carbon nanotube (Fe-N-C) that mimics enzyme-mediated electrocatalysis to achieve signal amplification.	Iron	149-153	uracil DNA glycosylase	Homo sapiens	104-107
31581012-5	2020	Complex iron in the saline-alkali soil were 30% higher than in the acidic paddy soil with the application of 40 t ha-1 biochar.	Iron	8-12	Rho GTPase activating protein 45	Homo sapiens	114-118
31740260-1	2020	We develop a low-background electrochemical biosensor for one-step detection of uracil DNA glycosylase (UDG) based on the host-guest interaction and iron-embedded nitrogen-rich carbon nanotube (Fe-N-C) that mimics enzyme-mediated electrocatalysis to achieve signal amplification.	Iron	194-200	uracil DNA glycosylase	Homo sapiens	80-102
31740260-1	2020	We develop a low-background electrochemical biosensor for one-step detection of uracil DNA glycosylase (UDG) based on the host-guest interaction and iron-embedded nitrogen-rich carbon nanotube (Fe-N-C) that mimics enzyme-mediated electrocatalysis to achieve signal amplification.	Iron	194-200	uracil DNA glycosylase	Homo sapiens	104-107
31888888-0	2020	Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein-Expressing Cells.	Iron	57-61	ATP binding cassette subfamily B member 1	Homo sapiens	75-89
31888888-5	2020	Strikingly, iron depletion was more pronounced in MDR cells due to the Pgp-mediated efflux of NSC297366-iron complexes.	Iron	12-16	ATP binding cassette subfamily B member 1	Homo sapiens	71-74
31888888-5	2020	Strikingly, iron depletion was more pronounced in MDR cells due to the Pgp-mediated efflux of NSC297366-iron complexes.	Iron	104-108	ATP binding cassette subfamily B member 1	Homo sapiens	71-74
31896574-0	2020	The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.	Iron	18-22	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	105-109
31656209-0	2020	Simultaneous supplementation with iron and folic acid can affect Slc11a2 and Slc46a1 transcription and metabolite concentrations in rats.	Iron	34-38	solute carrier family 11 member 2	Rattus norvegicus	65-72
32069829-7	2020	For the studied alloys, it was found that an increase in Fe content causesan increase in saturation magnetisation, and decreases in the values of the coercive field and thespin-wave stiffness parameter, Dspf.	Iron	57-59	tetratricopeptide repeat domain 37	Homo sapiens	169-176
31896574-7	2020	We defined Aft1- and Yap1-dependent transcriptional sites in the MMT1 promoter that are necessary for low iron- or oxidant-mediated MMT1 expression.	Iron	106-110	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	21-25
31819010-7	2020	The human acute phase protein haptoglobin (Hp) protects the host from oxidative damage by clearing hemoglobin that has leaked from red blood cells and also restricts the availability of extracellular Hb-bound iron to invading pathogens.	Iron	209-213	haptoglobin	Homo sapiens	30-41
32128489-12	2020	Screening for systemic iron overload with transferrin saturation and serum ferritin is the first step.	Iron	23-27	transferrin	Homo sapiens	42-53
32211498-0	2020	APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults.	Iron	36-40	apolipoprotein E	Homo sapiens	0-5
32211498-5	2020	DMN activity was enhanced in APOE4 carriers and related to cortical iron burden.	Iron	68-72	apolipoprotein E	Homo sapiens	29-34
32211498-7	2020	Secondary analysis revealed a positive, APOE4 associated, relationship between cortical iron and DMN connectivity.	Iron	88-92	apolipoprotein E	Homo sapiens	40-45
32211498-8	2020	Discussion: Our findings suggest that APOE4 moderates effects of iron on brain functionality prior to manifestation of cognitive impairment.	Iron	65-69	apolipoprotein E	Homo sapiens	38-43
31870832-0	2020	Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHII/eNOS/NO pathway.	Iron	52-56	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	87-93
31761321-13	2020	CONCLUSION: local hepcidin can regulate iron metabolism in the kidney by adjusting the expression of FPN1.	Iron	40-44	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	101-105
31800957-1	2020	Erythroferrone (ERFE) is critical for hepcidin suppression by erythropoietic drive to ensure adequate iron supply.	Iron	102-106	erythroferrone	Mus musculus	16-20
31870832-3	2020	Therefore, we aimed to explore the protective mechanism of Que on iron overload induced HUVECs injury focused on ROS/ADMA/DDAHII/eNOS/NO pathway.	Iron	66-70	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	122-128
31870832-9	2020	These results illustrated that Que could attenuate iron overload induced HUVECs mitochondrial dysfunction via ROS/ADMA/DDAHII/eNOS/NO pathway.	Iron	51-55	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	119-125
32033079-5	2020	Also, MA, DMF and MF exert anti-inflammatory effects through the expression of heme oxygenase (HO) -1, a stress-inducing enzyme that converts heme to carbon monoxide (CO), iron and biliberdine.	Iron	172-176	heme oxygenase 1	Mus musculus	79-101
32023254-7	2020	Additionally, the LIP was raised along with an elevated mRNA expression of ferritin and HO-1, as also iron exporters NRAMP-1 and Fpn-1.	Iron	102-106	solute carrier family 11 member 1	Homo sapiens	117-124
32023254-9	2020	However, enhancement of the iron exporters (NRAMP-1 and Fpn-1) defied the classical Ferritinlow/Ferroportinhigh phenotype of alternatively activated macrophages.	Iron	28-32	solute carrier family 11 member 1	Homo sapiens	44-51
31939292-5	2020	We employed a combined multiscale approach involving classical atomistic equilibrium and non-equilibrium MD simulations combined with QM/MM trajectories to investigate dioxygen diffusion to, and binding at, the active site in the PHD2.Fe(II).2OG.HIF substrate complex; PHD2 is the most important of the three human PHDs.	Iron	235-241	egl-9 family hypoxia inducible factor 1	Homo sapiens	230-234
32025297-7	2020	Periodic-acid Schiff, Alcian Blue pH 2.5 and high iron diamine staining on small and large intestine also demonstrated lower mucin staining intensity in the intestinal villi of HI10 and HI15 birds than C (P &lt; 0.05).	Iron	50-62	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	125-130
31927957-0	2020	Self-Assembly and Properties of a Discrete Water-Soluble Prussian Blue Analogue FeII/CoIII Cube: Confinement of a Water Molecule in Aqueous Solution.	Iron	80-84	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	85-90
31739109-4	2020	Upon the addition cell extract, the telomerase primer could extend and then hybridize with assistant DNA2 in the triple-helix, leading to the structure of triple-helix changes and release the hairpin DNA to hybridize with the capture DNA on the surface of Pt@P-MOF(Fe), resulting in the electrochemical signal readout of H2O2 reduction.	Iron	265-267	DNA replication helicase/nuclease 2	Homo sapiens	101-105
32099733-5	2020	The activities of caspase-3, caspase-8, and caspase-9 increased with increasing concentration of the nanoparticles indicating that activities of caspase can be activated by iron nanoparticles.	Iron	173-177	caspase 3	Homo sapiens	18-27
31724192-5	2020	In 58 individuals, who underwent oral iron challenge, carriage of the p.L390 M variant was associated with higher transferrin saturation and lower hepcidin release.	Iron	38-42	transferrin	Homo sapiens	114-125
31726603-2	2020	The time-fractional advection-dispersion equation (fADE) model was then employed to analyze the observed migration of HA-Fe/As(V).	Iron	121-123	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	124-129
31726603-1	2020	The transport behavior of arsenic (As(V)) loaded by ferric humate (HA-Fe) colloid, denoted as HA-Fe/As(V), moving in a saturated quartz sand column, was tested in the laboratory under varying pH values, ionic strengths, and HA and Fe(III) content.	Iron	70-72	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-40
31726603-1	2020	The transport behavior of arsenic (As(V)) loaded by ferric humate (HA-Fe) colloid, denoted as HA-Fe/As(V), moving in a saturated quartz sand column, was tested in the laboratory under varying pH values, ionic strengths, and HA and Fe(III) content.	Iron	97-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-40
31726603-6	2020	The ability of the HA-Fe colloid to load As(V) gradually increased with the increase of the Fe(III) concentration.	Iron	22-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
31726603-6	2020	The ability of the HA-Fe colloid to load As(V) gradually increased with the increase of the Fe(III) concentration.	Iron	92-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
31726603-7	2020	During the co-transport of the HA-Fe/As(V) colloid, transport of As(V) was promoted with increasing pH, increasing HA and Fe(III) content, and decreasing ionic strength in the saturated porous medium.	Iron	34-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
31726603-7	2020	During the co-transport of the HA-Fe/As(V) colloid, transport of As(V) was promoted with increasing pH, increasing HA and Fe(III) content, and decreasing ionic strength in the saturated porous medium.	Iron	122-129	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
31726603-7	2020	During the co-transport of the HA-Fe/As(V) colloid, transport of As(V) was promoted with increasing pH, increasing HA and Fe(III) content, and decreasing ionic strength in the saturated porous medium.	Iron	122-129	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
31726603-9	2020	The model analysis revealed that sub-diffusion of As(V) was weakened in the HA-Fe/As(V) colloid with high HA content.	Iron	79-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-55
31726603-9	2020	The model analysis revealed that sub-diffusion of As(V) was weakened in the HA-Fe/As(V) colloid with high HA content.	Iron	79-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-87
31726603-11	2020	When observing varying ionic strengths, As(V) exhibited stronger sub-diffusion in the HA-Fe/As(V) colloid with a higher ionic strength.	Iron	89-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-45
31726603-12	2020	As for the Fe(III) content, transport of As(V) was mainly affected by sub-diffusion in the HA-Fe/As(V) colloid with a low Fe(III) content.	Iron	11-18	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
31726603-12	2020	As for the Fe(III) content, transport of As(V) was mainly affected by sub-diffusion in the HA-Fe/As(V) colloid with a low Fe(III) content.	Iron	11-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
31726603-12	2020	As for the Fe(III) content, transport of As(V) was mainly affected by sub-diffusion in the HA-Fe/As(V) colloid with a low Fe(III) content.	Iron	122-129	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
31726603-13	2020	These findings provided direct and necessary insights into the effects of the HA-Fe colloid on the migration of As(V) throughout saturated porous media under different hydrochemical conditions found in natural environments.	Iron	81-83	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	112-117
31981986-9	2020	Transferrin saturation showed a similar decline with a consequent increase in unsaturated iron-binding capacity.	Iron	90-94	transferrin	Homo sapiens	0-11
32012242-5	2020	Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 .	Iron	286-290	bone morphogenetic protein 6	Homo sapiens	101-129
31937462-10	2020	Iron-binding capacity was transiently well utilized after dosing, as indicated by transferrin saturation >88% with 500-mg FCM and >90% with 1000-mg FCM.	Iron	0-4	transferrin	Homo sapiens	82-93
31907996-5	2020	We also showed that Iron Regulatory Protein 2 (IRP2) mediated iron-regulated Mdm2 expression.	Iron	62-66	iron responsive element binding protein 2	Homo sapiens	20-45
31908024-5	2020	Under iron depletion-induced stress, FKBP8 was recruited to the site of mitochondrial division through budding and colocalized with LC3.	Iron	6-10	FK506 binding protein 8	Mus musculus	37-42
31907996-5	2020	We also showed that Iron Regulatory Protein 2 (IRP2) mediated iron-regulated Mdm2 expression.	Iron	62-66	iron responsive element binding protein 2	Homo sapiens	47-51
31900819-0	2020	The PAP/SAL1 retrograde signaling pathway is involved in iron homeostasis.	Iron	57-61	SAL1 phosphatase-like protein	Arabidopsis thaliana	8-12
31734539-3	2020	Our results revealed that mesna binds stably to LPO within the SCN- binding site, dependent of the heme iron moiety, and its combination with LPO-Fe(III) is associated with a disturbance in the water molecule network in the heme cavity.	Iron	146-153	lactoperoxidase	Homo sapiens	142-145
31734539-5	2020	At higher concentrations, mesna also accelerated the formation of Compound II but it decays to LPO-Fe(III) directly or through the formation of an intermediate, Compound I*, that displays characteristic spectrum similar to that of LPO Compound I.	Iron	99-106	lactoperoxidase	Homo sapiens	95-98
31912279-14	2020	As demonstrated with the prototype chelator deferiprone, iron can be scavenged from labile iron complexes in the brain and transferred (conservatively) either to higher affinity acceptors in cells or extracellular transferrin.	Iron	57-61	transferrin	Homo sapiens	214-225
32042150-6	2020	We then find that pharmacological iron chelation mitigates the oligomerization of mutant CSPalpha, accompanied by partial rescue of the downstream SNARE defects and the pathological hallmark of lipofuscin accumulation.	Iron	34-38	small NF90 (ILF3) associated RNA E	Homo sapiens	147-152
31894555-8	2020	During the 6 months of iron administration, the erythropoietin dose was reduced in five patients and discontinued in one.	Iron	23-27	erythropoietin	Homo sapiens	48-62
31894555-9	2020	During the 3 months following the last iron infusion, three of them again raised the erythropoietin dose to previous levels.	Iron	39-43	erythropoietin	Homo sapiens	85-99
31894555-11	2020	CONCLUSIONS: A monthly maintenance intravenous dose of 100 mg iron sucrose may be a practical, effective, and safe in the short term, treatment of anemia in PD patients resulting in improved hemoglobin levels, iron indices, and erythropoietin response.	Iron	62-66	erythropoietin	Homo sapiens	228-242
31823109-5	2020	We report NARF to be associated in multiple sclerosis pathology and aberrant iron deposition.	Iron	77-81	nuclear prelamin A recognition factor	Homo sapiens	10-14
32042150-0	2020	Aggregation of mutant cysteine string protein-alpha via Fe-S cluster binding is mitigated by iron chelators.	Iron	56-60	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	22-51
32042150-0	2020	Aggregation of mutant cysteine string protein-alpha via Fe-S cluster binding is mitigated by iron chelators.	Iron	93-97	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	22-51
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	121-127
31900819-6	2020	In this work we studied Fe metabolism in three different mutants of the PAP/SAL1 retrograde pathway.	Iron	24-26	SAL1 phosphatase-like protein	Arabidopsis thaliana	76-80
31996760-0	2020	Author Correction: Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress.	Iron	19-23	insulin	Homo sapiens	32-39
31949017-8	2020	In Iron-Refractory Iron-Deficiency Anemia mutations of the hepcidin inhibitor TMPRSS6 upregulates the BMP/SMAD pathway.	Iron	3-7	transmembrane serine protease 6	Homo sapiens	78-85
31949017-9	2020	Interleukin-6 in acute and chronic inflammation, increases hepcidin levels causing iron-restricted erythropoiesis and anemia of inflammation in the presence of iron replete macrophages.	Iron	83-87	interleukin 6	Homo sapiens	0-13
31949017-9	2020	Interleukin-6 in acute and chronic inflammation, increases hepcidin levels causing iron-restricted erythropoiesis and anemia of inflammation in the presence of iron replete macrophages.	Iron	160-164	interleukin 6	Homo sapiens	0-13
31950948-2	2020	Non-transferrin bound iron (NTBI), labile plasma iron (LPI) and labile iron pool are redox-active forms of iron found in thalassemia.	Iron	22-26	transferrin	Homo sapiens	4-15
31901818-4	2020	It was found that Fe-bound NMPs (Fe-NMPs) showed outstanding peroxidase (POD)-like activity that possessed potential in antibacterial applications, and Mn-bound NMPs (Mn-NMPs) displayed catalase (CAT)-like activity with a remarkable radiotherapy sensitization effect in cancer therapy.	Iron	18-20	catalase	Homo sapiens	196-199
31927949-0	2020	Correction to Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1alpha Inhibitor Impairs Pancreatic Tumor Growth.	Iron	42-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-84
31774660-7	2020	Many of these proteins were associated with mitochondria and metabolism, especially iron metabolism, indicating that legumain may have a previously unknown impact on related processes.	Iron	84-88	legumain	Mus musculus	117-125
31901818-4	2020	It was found that Fe-bound NMPs (Fe-NMPs) showed outstanding peroxidase (POD)-like activity that possessed potential in antibacterial applications, and Mn-bound NMPs (Mn-NMPs) displayed catalase (CAT)-like activity with a remarkable radiotherapy sensitization effect in cancer therapy.	Iron	33-35	catalase	Homo sapiens	186-194
31901818-4	2020	It was found that Fe-bound NMPs (Fe-NMPs) showed outstanding peroxidase (POD)-like activity that possessed potential in antibacterial applications, and Mn-bound NMPs (Mn-NMPs) displayed catalase (CAT)-like activity with a remarkable radiotherapy sensitization effect in cancer therapy.	Iron	18-20	catalase	Homo sapiens	186-194
31901818-4	2020	It was found that Fe-bound NMPs (Fe-NMPs) showed outstanding peroxidase (POD)-like activity that possessed potential in antibacterial applications, and Mn-bound NMPs (Mn-NMPs) displayed catalase (CAT)-like activity with a remarkable radiotherapy sensitization effect in cancer therapy.	Iron	33-35	catalase	Homo sapiens	196-199
31639234-2	2020	Iron (III) ions could be incorporated into the H-MSN to form hollow and microporous Fe-salen network (H-MFeSN) with enhanced microporosity and surface area.	Iron	0-10	moesin	Homo sapiens	49-52
31979011-7	2020	Correlation analyses showed that lower miR-133b levels were associated with poor nutritional status (Mini Nutritional Assessment Long Form (MNA-LF) score, p = 0.005); furthermore, correlations with albumin, ferritin, and iron were found.	Iron	221-225	microRNA 133b	Homo sapiens	39-47
31891258-3	2020	57Fe Mossbauer spectroscopy shows that two-thirds of the total spins in the  [FeIII4FeII2] diamond chain are spin-5/2 (high-spin FeIII), while the remaining one-third are spin-2 (high-spin FeII).	Iron	78-83	spindlin family member 2A	Homo sapiens	109-117
31891258-3	2020	57Fe Mossbauer spectroscopy shows that two-thirds of the total spins in the  [FeIII4FeII2] diamond chain are spin-5/2 (high-spin FeIII), while the remaining one-third are spin-2 (high-spin FeII).	Iron	78-83	spindlin family member 2A	Homo sapiens	171-177
31891258-3	2020	57Fe Mossbauer spectroscopy shows that two-thirds of the total spins in the  [FeIII4FeII2] diamond chain are spin-5/2 (high-spin FeIII), while the remaining one-third are spin-2 (high-spin FeII).	Iron	78-82	spindlin family member 2A	Homo sapiens	109-117
31891258-3	2020	57Fe Mossbauer spectroscopy shows that two-thirds of the total spins in the  [FeIII4FeII2] diamond chain are spin-5/2 (high-spin FeIII), while the remaining one-third are spin-2 (high-spin FeII).	Iron	78-82	spindlin family member 2A	Homo sapiens	171-177
32099899-7	2020	We demonstrate that TfR1 plays a crucial role for a rapid and transient activation of the ERK signaling pathway, which induces a deregulation of genes involved in the aberrant accumulation of intracellular free iron and in drug resistance.	Iron	211-215	mitogen-activated protein kinase 1	Homo sapiens	90-93
31980600-0	2020	African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.	Iron	39-43	tumor protein p53	Homo sapiens	16-20
31980600-8	2020	African Americans with elevated saturated transferrin and serum ferritin show higher prevalence of the P47S variant (OR = 1.68 (95%CI 1.07-2.65) p = 0.023), suggestive of its role in iron accumulation in humans.	Iron	183-187	transferrin	Homo sapiens	42-53
31891258-3	2020	57Fe Mossbauer spectroscopy shows that two-thirds of the total spins in the  [FeIII4FeII2] diamond chain are spin-5/2 (high-spin FeIII), while the remaining one-third are spin-2 (high-spin FeII).	Iron	78-89	spindlin family member 2A	Homo sapiens	109-117
31891258-3	2020	57Fe Mossbauer spectroscopy shows that two-thirds of the total spins in the  [FeIII4FeII2] diamond chain are spin-5/2 (high-spin FeIII), while the remaining one-third are spin-2 (high-spin FeII).	Iron	78-89	spindlin family member 2A	Homo sapiens	171-177
31830506-1	2020	Angiotensin II (ANGII) modulates expression of iron intake and export proteins in cultured neurons.	Iron	47-51	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-14
31830506-1	2020	Angiotensin II (ANGII) modulates expression of iron intake and export proteins in cultured neurons.	Iron	47-51	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	16-21
31941883-0	2020	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	0-4
31801692-8	2020	Docking results for the corresponding CYP4B1-substrate complexes revealed that fatty acids can adopt U-shaped bonding conformations, such that carbon atoms in both arms may approach the heme-iron.	Iron	191-195	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	38-44
31941883-0	2020	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.	Iron	42-46	insulin	Homo sapiens	15-22
31941883-6	2020	Iron normalizes ms2t6A37 and proinsulin lysine incorporation, restoring insulin content and secretion in Irp2-/- beta cells.	Iron	0-4	insulin	Homo sapiens	29-39
31941883-3	2020	Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes functional iron deficiency in beta cells.	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	0-4
31941883-6	2020	Iron normalizes ms2t6A37 and proinsulin lysine incorporation, restoring insulin content and secretion in Irp2-/- beta cells.	Iron	0-4	insulin	Homo sapiens	32-39
31941883-6	2020	Iron normalizes ms2t6A37 and proinsulin lysine incorporation, restoring insulin content and secretion in Irp2-/- beta cells.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	105-109
31941883-3	2020	Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes functional iron deficiency in beta cells.	Iron	100-104	iron responsive element binding protein 2	Homo sapiens	0-4
31936571-3	2020	Instead, ferroptotic cells die following iron-dependent lipid peroxidation, a process which is antagonised by glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1).	Iron	41-45	atlastin GTPase 1	Homo sapiens	146-178
31559819-8	2020	Expression of biomarkers related to the neuronal differentiation of TMSCs, including NFM, MAP2, GFAP, NURR1, NSE, and TUBB3, increased 4-35-fold at the mRNA level in the Fe3+-containing system compared to that of the system without Fe3+.	Iron	170-174	enolase 2	Homo sapiens	109-112
31936571-3	2020	Instead, ferroptotic cells die following iron-dependent lipid peroxidation, a process which is antagonised by glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1).	Iron	41-45	atlastin GTPase 1	Homo sapiens	180-184
32278667-5	2020	RESULTS: Following HCV eradication, serum iron, transferrin-iron saturation and ferritin levels decreased significantly (pre- versus post-treatment, p<0.01 for each).	Iron	60-64	transferrin	Homo sapiens	48-59
31793576-5	2020	The nanostructured powder consists of agglomerates of small particles (mean diameter of 85(41) nm) and transforms into well-known beta-MnB with FeB-type structure at 1523 K. The room temperature ferromagnetic behavior (TC = 545 K) is attributed to the positive exchange-correlation between the manganese atoms, that have many unpaired d electrons.	Iron	144-147	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	135-138
32256196-12	2020	Conclusions: The results indicate that exposure levels of PM in the iron foundry environment can affect the NLRP3 inflammasome and systemic inflammation.	Iron	68-72	NLR family pyrin domain containing 3	Homo sapiens	108-113
31935934-0	2020	Iron-Catalyzed C(sp2)-C(sp3) Cross-Coupling of Aryl Chlorobenzoates with Alkyl Grignard Reagents.	Iron	0-4	Sp2 transcription factor	Homo sapiens	15-20
31935934-2	2020	Herein, we report the iron-catalyzed C(sp2)-C(sp3) Kumada cross-coupling of aryl chlorobenzoates with alkyl Grignard reagents.	Iron	22-26	Sp2 transcription factor	Homo sapiens	37-42
31533096-0	2020	Iron Support in Erythropoietin Treatment in Myelodysplastic Syndrome Patients Affected by Low-Risk Refractory Anaemia: Real-Life Evidence from an Italian Setting.	Iron	0-4	erythropoietin	Homo sapiens	16-30
31533096-2	2020	In low-risk lymphoma and solid tumour patients, iron support improves erythropoietin (EPO) cost-effectiveness in treating anaemia.	Iron	48-52	erythropoietin	Homo sapiens	70-84
31533096-2	2020	In low-risk lymphoma and solid tumour patients, iron support improves erythropoietin (EPO) cost-effectiveness in treating anaemia.	Iron	48-52	erythropoietin	Homo sapiens	86-89
31533096-3	2020	The aim of this study is to see if oral sucrosomial iron support improves the cost-effectiveness of EPO treatment in MDS patients affected by low-risk RA.	Iron	52-56	erythropoietin	Homo sapiens	100-103
31533096-10	2020	EPO treatment-related expenditures in MDS-RA patients were lowest with oral sucrosomial iron supplementation (Sideral ), with a longer interval between EPO administration in maintenance treatment, quicker hemoglobin recovery, lower ferritin increase and fewer blood transfusions.	Iron	88-92	erythropoietin	Homo sapiens	0-3
31533096-10	2020	EPO treatment-related expenditures in MDS-RA patients were lowest with oral sucrosomial iron supplementation (Sideral ), with a longer interval between EPO administration in maintenance treatment, quicker hemoglobin recovery, lower ferritin increase and fewer blood transfusions.	Iron	88-92	erythropoietin	Homo sapiens	152-155
31793717-4	2020	This reaction simultaneously produces abundant H2 O2 to induce cell death and damage the structure of transferrin to release Fe3+ , which will react with H2 O2 to produce highly toxic  OH to kill tumor cells.	Iron	125-129	transferrin	Homo sapiens	102-113
32212941-4	2020	Sclerostin showed significant associations with the Z-scores at the lumbar spine and femoral neck, osteocalcin, beta-cross laps, osteoprotegerin, sRANKL, pretransfusion haemoglobin, liver iron concentration and female gonadal state.	Iron	188-192	sclerostin	Homo sapiens	0-10
31740582-4	2020	We noted that these genes are involved in the synthesis of glutathione or metabolism of intracellular labile iron and include glutamate-cysteine ligase modifier subunit (Gclm), solute carrier family 7 member 11 (Slc7a11), ferritin heavy chain 1 (Fth1), ferritin light chain 1 (Ftl1), and solute carrier family 40 member 1 (Slc40a1).	Iron	109-113	LOC100862446	Mus musculus	253-275
31740582-4	2020	We noted that these genes are involved in the synthesis of glutathione or metabolism of intracellular labile iron and include glutamate-cysteine ligase modifier subunit (Gclm), solute carrier family 7 member 11 (Slc7a11), ferritin heavy chain 1 (Fth1), ferritin light chain 1 (Ftl1), and solute carrier family 40 member 1 (Slc40a1).	Iron	109-113	LOC100862446	Mus musculus	277-281
31740582-4	2020	We noted that these genes are involved in the synthesis of glutathione or metabolism of intracellular labile iron and include glutamate-cysteine ligase modifier subunit (Gclm), solute carrier family 7 member 11 (Slc7a11), ferritin heavy chain 1 (Fth1), ferritin light chain 1 (Ftl1), and solute carrier family 40 member 1 (Slc40a1).	Iron	109-113	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	288-321
31740582-4	2020	We noted that these genes are involved in the synthesis of glutathione or metabolism of intracellular labile iron and include glutamate-cysteine ligase modifier subunit (Gclm), solute carrier family 7 member 11 (Slc7a11), ferritin heavy chain 1 (Fth1), ferritin light chain 1 (Ftl1), and solute carrier family 40 member 1 (Slc40a1).	Iron	109-113	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	323-330
31674058-11	2020	There was a temporary decrease in mean serum iron levels with VIT-2763 single doses >=60 mg and all multiple doses; mean calculated transferrin saturation (only assessed following multiple dosing) also temporarily decreased.	Iron	45-49	vitrin	Homo sapiens	62-65
31674058-12	2020	A shift in mean serum hepcidin peaks followed administration of all iron-lowering doses of VIT-2763.	Iron	68-72	vitrin	Homo sapiens	91-94
31834456-2	2020	The recently discovered erythroid regulator, erythroferrone (ERFE), governed by high levels of erythropoietin, was found to suppress hepcidin expression, thus increasing iron availability for developing erythroid progenitors.	Iron	170-174	erythropoietin	Homo sapiens	95-109
32278667-6	2020	Serum iron and/or transferrin-iron saturations normalized in 16/19 subjects and raised ferritin levels returned to the normal range in 14/18 subjects, including several with pretreatment transferrin-iron saturation >90% and/or serum ferritin >1000ng/mL.	Iron	30-34	transferrin	Homo sapiens	18-29
32278667-6	2020	Serum iron and/or transferrin-iron saturations normalized in 16/19 subjects and raised ferritin levels returned to the normal range in 14/18 subjects, including several with pretreatment transferrin-iron saturation >90% and/or serum ferritin >1000ng/mL.	Iron	30-34	transferrin	Homo sapiens	18-29
31678680-0	2020	Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis.	Iron	11-15	interleukin 6	Homo sapiens	185-198
32229441-5	2020	Transferrin saturation (TSAT, %) was calculated as (serum iron x 100)/TIBC.	Iron	58-62	transferrin	Homo sapiens	0-11
30835084-4	2020	Appearance of early and late apoptotic cells with altered nuclear morphology and increased expression of effector proteins, i.e., cleaved Caspase 3 and cleaved PARP (Poly-ADP-ribose Polymerase), clearly confirmed iron-induced apoptotic cell deaths.	Iron	213-217	poly(ADP-ribose) polymerase 1	Homo sapiens	160-164
30835084-4	2020	Appearance of early and late apoptotic cells with altered nuclear morphology and increased expression of effector proteins, i.e., cleaved Caspase 3 and cleaved PARP (Poly-ADP-ribose Polymerase), clearly confirmed iron-induced apoptotic cell deaths.	Iron	213-217	poly(ADP-ribose) polymerase 1	Homo sapiens	166-192
31678680-0	2020	Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis.	Iron	11-15	signal transducer and activator of transcription 3	Homo sapiens	199-204
31602812-10	2020	Greater height/age (p&lt;0.01) and higher level of total allergen IgE (p&lt;0.01) are associated with higher value of FeNO.	Iron	118-122	immunoglobulin heavy constant epsilon	Homo sapiens	66-69
31221534-1	2020	INTRODUCTION AND OBJECTIVES: Haptoglobin is a protein involved in the protection against oxidative damage caused by iron in haemoglobin.	Iron	116-120	haptoglobin	Homo sapiens	29-40
31602812-12	2020	CONCLUSIONS: Height and T-IgE are well correlated with FeNO in asthmatic children aged 5 to 12 years.	Iron	55-59	immunoglobulin heavy constant epsilon	Homo sapiens	26-29
31657968-3	2020	The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis.	Iron	24-28	interleukin 6	Homo sapiens	233-237
31475901-3	2020	In the case of MCD, it was observed that IL-6 is overproduced from T-cells and macrophage which disturbs Hepcidin, a vital regulator of iron trafficking in macrophage.	Iron	136-140	interleukin 6	Homo sapiens	41-45
32000639-6	2020	Iron removal combined with healthy diet improved both insulin sensitivity and beta cell function, but had no significant effect on blood glucose; phlebotomy therapy might be considered with conflicting results however.	Iron	0-4	insulin	Homo sapiens	54-61
32003680-4	2020	The pathogenetic mechanisms linking insulin resistance (IR), NAFLD and DIOS to iron overload are still debated.	Iron	79-83	insulin	Homo sapiens	36-43
33654328-1	2020	Materials such as L10 Fe-based alloys with perpendicular magnetic anisotropy derived from crystal structure have the potential to deliver higher thermal stability of magnetic memory elements compared to materials whose anisotropy is derived from surfaces and interfaces.	Iron	22-24	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	18-21
31820684-1	2020	BACKGROUND: The role of Fe+2, Cu+2 and Zn+2 in facilitating aggregation of Amyloid beta (Abeta) and consequently, the progression of Alzheimer"s disease (AD) is well established.	Iron	24-26	amyloid beta precursor protein	Homo sapiens	75-87
31820684-1	2020	BACKGROUND: The role of Fe+2, Cu+2 and Zn+2 in facilitating aggregation of Amyloid beta (Abeta) and consequently, the progression of Alzheimer"s disease (AD) is well established.	Iron	24-26	amyloid beta precursor protein	Homo sapiens	89-94
31179826-5	2020	Our findings demonstrate that altering intestinal iron availability during community assembly modulated the microbiota in non-inflamed wild type (WT) and colitis-susceptible interleukin-10-deficient (Il10-/-) mice.	Iron	50-54	interleukin 10	Mus musculus	174-188
31179826-8	2020	In contrast, distinct luminal community assembly was observed with dietary iron supplementation in WT versus Il10-/- mice, suggesting that the effects of increased iron on the microbiota differ with host inflammation status.	Iron	75-79	interleukin 10	Mus musculus	109-113
31179826-8	2020	In contrast, distinct luminal community assembly was observed with dietary iron supplementation in WT versus Il10-/- mice, suggesting that the effects of increased iron on the microbiota differ with host inflammation status.	Iron	164-168	interleukin 10	Mus musculus	109-113
32568195-2	2020	Heme oxygenase 1 (HO-1) is a stress protein that catalyzes the degradation of heme into free iron, biliverdin, and carbon monoxide.	Iron	93-97	heme oxygenase 1	Mus musculus	0-16
32568195-2	2020	Heme oxygenase 1 (HO-1) is a stress protein that catalyzes the degradation of heme into free iron, biliverdin, and carbon monoxide.	Iron	93-97	heme oxygenase 1	Mus musculus	18-22
31657968-3	2020	The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis.	Iron	24-28	tumor necrosis factor	Homo sapiens	243-270
31657968-3	2020	The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis.	Iron	24-28	tumor necrosis factor	Homo sapiens	272-281
31760034-3	2020	Focusing on Alzheimer"s disease (AD), we found that the iron chelators deferoxamine and deferiprone inhibited amyloid-beta (Abeta)-induced Lcn2 production in cultured primary astrocytes.	Iron	56-60	amyloid beta precursor protein	Homo sapiens	110-122
31425659-9	2020	The former has chemotactic activity on various types of lymphocytes and enhances collagen production from fibroblasts, while lactotransferrin is an iron-binding protein abundantly present in milk and has a wide range of functions, including fibroblast proliferation and maturation of dendritic cells (DCs).	Iron	148-152	lactotransferrin	Homo sapiens	125-141
31669693-1	2020	Transferrin, the major iron transport protein in the blood, apparently also transports trivalent chromium in vivo via endocytosis.	Iron	23-27	transferrin	Homo sapiens	0-11
31760034-3	2020	Focusing on Alzheimer"s disease (AD), we found that the iron chelators deferoxamine and deferiprone inhibited amyloid-beta (Abeta)-induced Lcn2 production in cultured primary astrocytes.	Iron	56-60	amyloid beta precursor protein	Homo sapiens	124-129
31760034-4	2020	Accordingly, Abeta-exposure increased astrocytic ferritin production, indicating the possibility that Abeta induces iron accumulation in astrocytes.	Iron	116-120	amyloid beta precursor protein	Homo sapiens	13-18
31760034-4	2020	Accordingly, Abeta-exposure increased astrocytic ferritin production, indicating the possibility that Abeta induces iron accumulation in astrocytes.	Iron	116-120	amyloid beta precursor protein	Homo sapiens	102-107
32507812-2	2020	Iron refractory iron deficiency anemia (IRIDA) is a genetic disorder caused by a defect in the TMPRSS6 gene encoding matriptase-2, a transmembrane serine protease that physiologically inhibits hepcidin production.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	95-102
31678147-1	2020	The effects of deoxyhemoglobin (Hb) and albumin on the NO-donor activity of the anionic tetranitrosyl iron complex with thiosulfate ligands (1) were studied for the first time.	Iron	102-106	albumin	Homo sapiens	40-47
32507812-2	2020	Iron refractory iron deficiency anemia (IRIDA) is a genetic disorder caused by a defect in the TMPRSS6 gene encoding matriptase-2, a transmembrane serine protease that physiologically inhibits hepcidin production.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	117-129
32759562-11	2020	Erythropoiesis-stimulating agents and thrombopoietin receptor agonists could also improve refractory anemia or BMFS and improve iron overload.	Iron	128-132	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	38-61
33162505-6	2020	Moreover, IL-6 upregulates the production of hepcidin, the master regulator of systemic iron metabolism, in the liver.	Iron	88-92	interleukin 6	Homo sapiens	10-14
31839527-2	2020	HEPCIDIN, encoded by Hamp, is a hormone that negatively regulates iron homeostasis.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
31839527-2	2020	HEPCIDIN, encoded by Hamp, is a hormone that negatively regulates iron homeostasis.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	21-25
31839527-13	2020	CONCLUSIONS: Our data demonstrate that elevated DNA methylation of the Hamp promoter region suppresses its expression, this epigenetic modification likely occurs in reaction to iron deficiency after bariatric surgery, helping to maintain system iron homeostasis.	Iron	177-181	hepcidin antimicrobial peptide	Rattus norvegicus	71-75
31669099-0	2020	Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway.	Iron	29-33	aryl-hydrocarbon receptor	Mus musculus	91-116
31903126-4	2020	Tf-DBC NPs could specifically recognize cancer cells via Tf-Tf receptor binding and be uptaken into the lysosomes of cancer cells, where Tf-DBC NPs were activated to release Fe(II), DHA, and BSO.	Iron	174-180	transferrin	Homo sapiens	0-2
32253873-1	2020	Iron-refractory iron deficiency anemia (IRIDA) is an inherited iron metabolism disorder caused by mutations in TMPRSS6 gene encoding matriptase-2, which results in increased hepcidin synthesis.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	111-118
32253873-1	2020	Iron-refractory iron deficiency anemia (IRIDA) is an inherited iron metabolism disorder caused by mutations in TMPRSS6 gene encoding matriptase-2, which results in increased hepcidin synthesis.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	133-145
32759563-5	2020	In time-dependent cox hazard analysis, we found the higher risks of cardiovascular disease (HR: 4.45, p<0.001) and all-cause mortality (HR: 5.8, p< 0.001) in patients with low transferrin saturation (TSAT) (<20%) and high ferritin levels (>=100 ng/ml) who are suspected to have iron dysregulation for erythropoiesis compared with patients with high TSAT and low ferritin level.	Iron	278-282	transferrin	Homo sapiens	176-187
31704097-4	2019	BVR-deficiency induces the activity of Nrf2 transcription factor and increases heme oxygenase-1 (HO-1) level, which is accompanied by the reduction of cellular heme content, increase in a free iron fraction and oxidative stress.	Iron	193-197	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
31906219-4	2019	The experimental results indicated that the maximum adsorption capacity (qmax) of Fe@BC for DCF obtained from Langmuir isotherm simulation was 123.45 mg L-1 and it was a remarkable value of DCF adsorption in comparison with that of other biomass-based adsorbents previously reported.	Iron	82-84	L1 cell adhesion molecule	Homo sapiens	153-156
31879716-0	2019	Mobility and localization of the iron deficiency-induced transcription factor bHLH039 change in the presence of FIT.	Iron	33-37	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	78-85
31879716-2	2019	In Arabidopsis, Fe deficiency-induced bHLH039 forms a complex with the master regulator FIT and activates it to upregulate Fe acquisition genes.	Iron	16-18	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	38-45
31879716-2	2019	In Arabidopsis, Fe deficiency-induced bHLH039 forms a complex with the master regulator FIT and activates it to upregulate Fe acquisition genes.	Iron	123-125	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	38-45
31949885-1	2019	Summary: The present investigation found that curculigoside (CUR) can prevent excess-iron-induced bone loss in mice and cells through antioxidation and inhibiting excess-iron-induced phosphorylation of the Akt-FoxO1 pathway.	Iron	170-174	thymoma viral proto-oncogene 1	Mus musculus	206-209
31609578-7	2019	While hPirin is iron-dependent, YhhW is identified as a novel nickel-containing dioxygenase member of the bicupin family.	Iron	16-20	pirin	Homo sapiens	6-12
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	50-54	transferrin	Homo sapiens	83-94
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	50-54	transferrin	Homo sapiens	96-98
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	106-110	transferrin	Homo sapiens	83-94
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	106-110	transferrin	Homo sapiens	96-98
31539545-5	2019	Iron management proteins lipocalin 2 (LCN2) and ferritin(FTL) exhibited distinct postinjury time courses, where peak LCN2 response preceded, and FTL followed that of HO-1.	Iron	0-4	ferritin light chain 1	Rattus norvegicus	57-60
31539545-5	2019	Iron management proteins lipocalin 2 (LCN2) and ferritin(FTL) exhibited distinct postinjury time courses, where peak LCN2 response preceded, and FTL followed that of HO-1.	Iron	0-4	ferritin light chain 1	Rattus norvegicus	145-148
31539545-7	2019	Upregulation of FTL for intracellular iron sequestration was delayed relative to both HO-1 and LCN2 induction.	Iron	38-42	ferritin light chain 1	Rattus norvegicus	16-19
31387860-0	2019	VAC14 syndrome in two siblings with retinitis pigmentosa and neurodegeneration with brain iron accumulation.	Iron	90-94	VAC14 component of PIKFYVE complex	Homo sapiens	0-5
31563708-4	2019	Batch experiments show that the adsorption capacities of Fe-NN/BFs for As(V) and As(III) reach to 93.94 and 70.22 mg/g-Fe at pH 7.0, respectively.	Iron	57-62	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	71-76
31563708-4	2019	Batch experiments show that the adsorption capacities of Fe-NN/BFs for As(V) and As(III) reach to 93.94 and 70.22 mg/g-Fe at pH 7.0, respectively.	Iron	57-59	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	71-76
31563708-5	2019	As(V) levels (275 mug/L) in groundwater are rapidly reduced (less than 5 min) to below 10 mug/L using Fe-NN/BFs (1 g/L) at pH 6.7.	Iron	102-107	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
31835326-2	2019	The catalytic activity of the resulting material (wSF-DA/Fe) was investigated in Fenton-like removal of toxic aromatic dyes (Methylene Blue, Cationic Violet X-5BLN, and Reactive Orange GRN) water.	Iron	57-59	granulin precursor	Homo sapiens	185-188
31612883-7	2019	Their regulatory networks highlighted HNF4a as a bridge and linked them to important processes such as EMT-MET transitions, ECM remodeling and liver development pathways (HNF3, PPARA signaling, iron metabolism) along the different steps of differentiation.	Iron	194-198	hepatocyte nuclear factor 4 alpha	Homo sapiens	38-43
31641439-1	2019	Methanogens are putatively ancestral autotrophs that reduce CO2 with H2 to form biomass using a membrane-bound, proton-motive Fe(Ni)S protein called the energy-converting hydrogenase (Ech).	Iron	126-128	solute carrier family 5 member 5	Homo sapiens	129-133
31641439-2	2019	At the origin of life, geologically sustained H+ gradients across inorganic barriers containing Fe(Ni)S minerals could theoretically have driven CO2 reduction by H2 through vectorial chemistry in a similar way to Ech.	Iron	96-98	solute carrier family 5 member 5	Homo sapiens	99-103
31641439-3	2019	pH modulation of the redox potentials of H2, CO2 and Fe(Ni)S minerals could in principle enable an otherwise endergonic reaction.	Iron	53-55	solute carrier family 5 member 5	Homo sapiens	56-60
31641439-5	2019	We present pilot data showing that steep pH gradients of approximately 5 pH units can be sustained over greater than 5 h across Fe(Ni)S barriers, with H+-flux across the barrier about two million-fold faster than OH--flux.	Iron	128-130	solute carrier family 5 member 5	Homo sapiens	131-135
31867514-5	2019	Density functional theory simulations showed that 4-methylanisole presents a stronger pi-pi interaction and attraction forces with sp2 carbon nanosheets in Fe@C composites than 4-anisaldehyde.	Iron	156-158	sex-specific storage-protein 2	Bombyx mori	131-134
31577132-5	2019	In comparison with the results obtained with other cathode materials (Ti, Cu, Co3O4, and Fe2O3) and obtained by other researchers, the new process shows a faster NO3--N reduction rate and much higher N2 selectivity.	Iron	89-94	NBL1, DAN family BMP antagonist	Homo sapiens	162-165
31613630-5	2019	The iron-carrying CPNPs reported here are targeted to endothelin-B receptors (EDNRB) through endothelin-3 surface moieties (EDN3-CPNPs).	Iron	4-8	endothelin receptor type B	Homo sapiens	78-83
31578193-4	2019	Correlation with eGFR identified genes in the pathways of iron transport and cell differentiation to be positively associated with eGFR, while those in the immune response and fibrosis pathways were negatively associated.	Iron	58-62	epidermal growth factor receptor	Homo sapiens	17-21
31504095-11	2019	In mixed models, CRP was associated with ferritin (positive) and serum iron and retinol (negative, P &lt; 0.05).	Iron	71-75	C-reactive protein	Homo sapiens	17-20
31159605-5	2019	This binary complex was in turn coupled to the iron carrier protein, transferrin, which engages a high-affinity cell surface receptor.	Iron	47-51	transferrin	Homo sapiens	69-80
31578193-4	2019	Correlation with eGFR identified genes in the pathways of iron transport and cell differentiation to be positively associated with eGFR, while those in the immune response and fibrosis pathways were negatively associated.	Iron	58-62	epidermal growth factor receptor	Homo sapiens	131-135
31660701-1	2019	Pantothenate kinase-associated neurodegeneration (PKAN) is an inborn error of CoA metabolism causing dystonia, parkinsonism, and brain iron accumulation.	Iron	135-139	pantothenate kinase 2	Homo sapiens	0-48
31660701-1	2019	Pantothenate kinase-associated neurodegeneration (PKAN) is an inborn error of CoA metabolism causing dystonia, parkinsonism, and brain iron accumulation.	Iron	135-139	pantothenate kinase 2	Homo sapiens	50-54
31908613-5	2019	Levels of circulating iron biomarkers are an easily available alternative; especially, ferritin and transferrin saturation (Tsat).	Iron	22-26	transferrin	Homo sapiens	100-111
31610507-7	2019	The abundant unsaturated metal active sites of Fe(II) and Co(II) in the skeleton of FeCo-BDC made a great contribution to the generation of sulfate () and hydroxyl radicals (OH), which resulted in the excellent performance for MB degradation.	Iron	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
31569998-0	2019	Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2.	Iron	55-59	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
31569998-6	2019	Decreased NRF2 expression in the nucleus resulted in a decrease in its transcriptional target ferroportin, encoding the sole macrophage iron exporter, thus ultimately decreasing iron efflux and increasing the intracellular iron content.	Iron	136-140	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
31569998-6	2019	Decreased NRF2 expression in the nucleus resulted in a decrease in its transcriptional target ferroportin, encoding the sole macrophage iron exporter, thus ultimately decreasing iron efflux and increasing the intracellular iron content.	Iron	178-182	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
31569998-6	2019	Decreased NRF2 expression in the nucleus resulted in a decrease in its transcriptional target ferroportin, encoding the sole macrophage iron exporter, thus ultimately decreasing iron efflux and increasing the intracellular iron content.	Iron	178-182	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
30095041-3	2019	Apolipoprotein E and Glutathione S-transferase act as the scavenger of free radicals, which are generated due to excess iron.	Iron	120-124	apolipoprotein E	Homo sapiens	0-16
30391296-2	2019	The results showed that the silkworm was responsive to iron by increasing iron concentration and ferritin levels in the hemolymph and by regulating the expression of many other genes.	Iron	55-59	ferritin	Bombyx mori	97-105
31644952-8	2019	Recent advances, however, shows a multifaceted role for Nrf2 in the regulation of genes connected with inflammatory response, metabolic pathways, protein homeostasis, iron management, and mitochondrial bioenergetics.	Iron	167-171	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
31069605-11	2019	OA + Fe and OA + Zn displayed significant decrease in DTH, NO, expression of IL-4, 5, 13, 17, toll-like receptor-2, nuclear factor-kappa B and tumor necrosis factor-alpha; serum IgE, COX-2, and 5-LOX.	Iron	5-7	toll-like receptor 2	Rattus norvegicus	77-114
31069605-11	2019	OA + Fe and OA + Zn displayed significant decrease in DTH, NO, expression of IL-4, 5, 13, 17, toll-like receptor-2, nuclear factor-kappa B and tumor necrosis factor-alpha; serum IgE, COX-2, and 5-LOX.	Iron	5-7	tumor necrosis factor	Rattus norvegicus	143-170
31578640-0	2019	Is brain iron trafficking part of the physiology of the amyloid precursor protein?	Iron	9-13	amyloid beta precursor protein	Homo sapiens	56-81
31514090-2	2019	THB1, the protein product of the Chlamydomonas reinhardtii THB1 gene, is a group 1 truncated hemoglobin that uses a lysine residue in the E helix (Lys53, at position E10 by reference to myoglobin) as an iron ligand at neutral pH.	Iron	203-207	uncharacterized protein	Chlamydomonas reinhardtii	0-4
31514090-2	2019	THB1, the protein product of the Chlamydomonas reinhardtii THB1 gene, is a group 1 truncated hemoglobin that uses a lysine residue in the E helix (Lys53, at position E10 by reference to myoglobin) as an iron ligand at neutral pH.	Iron	203-207	uncharacterized protein	Chlamydomonas reinhardtii	59-63
31871543-1	2019	5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid.	Iron	29-33	arachidonate 5-lipoxygenase	Homo sapiens	0-14
31727545-0	2019	After haemin treatment intracellular non-haem iron increases prior to haem oxygenase-1 induction: A study in human monocytic cell line THP-1.	Iron	46-50	GLI family zinc finger 2	Homo sapiens	135-140
31727545-3	2019	We previously demonstrated that haemin-induced cell death in human monocytic THP-1 cells is consistent with ferroptosis, an iron-dependent cell death regulation mechanism.	Iron	124-128	GLI family zinc finger 2	Homo sapiens	77-82
31871543-1	2019	5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid.	Iron	29-33	arachidonate 5-lipoxygenase	Homo sapiens	16-21
31871543-6	2019	Meanwhile, it has been shown that ALOX5 activity is regulated by several factors including protein phosphorylation, ALOX5-interactng protein, redox state, and metal ions such as iron and calcium.	Iron	178-182	arachidonate 5-lipoxygenase	Homo sapiens	34-39
31543462-2	2019	Accumulated evidence has revealed that hepcidin, the master regulator of iron homeostasis, is negatively modulated by TMPRSS6 (matriptase-2), a liver-specific type II transmembrane serine protease (TTSP).	Iron	73-77	transmembrane serine protease 6	Homo sapiens	118-125
31827466-2	2019	We have exploited the substrate ambiguity of the ectoine hydroxylase (EctD), a member of the non-heme Fe(II)-containing and 2-oxoglutarate-dependent dioxygenase superfamily, for such a task.	Iron	102-108	ectoine hydroxylase	Pseudomonas stutzeri	49-68
31827466-2	2019	We have exploited the substrate ambiguity of the ectoine hydroxylase (EctD), a member of the non-heme Fe(II)-containing and 2-oxoglutarate-dependent dioxygenase superfamily, for such a task.	Iron	102-108	ectoine hydroxylase	Pseudomonas stutzeri	70-74
31771607-8	2019	The malaria pathway upregulates C-reactive protein and serum hepcidin, thereby reducing iron absorption.	Iron	88-92	C-reactive protein	Homo sapiens	32-50
31763971-9	2021	Its mechanism is proposed that a nucleophilic addition of iron-peroxo species, generated by CYP2D6 and CYP3A4/5, to the carbonyl group caused the carbon-carbon bond cleavage between the adjacent hydroxyl and ketone groups.	Iron	58-69	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	92-98
31763971-9	2021	Its mechanism is proposed that a nucleophilic addition of iron-peroxo species, generated by CYP2D6 and CYP3A4/5, to the carbonyl group caused the carbon-carbon bond cleavage between the adjacent hydroxyl and ketone groups.	Iron	58-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-109
31871809-6	2019	This study revealed that everolimus treatment improved impaired social cognition with increased serum levels of the copper mediator (Cp) and iron mediator (Tf) via homeostatic control of mTOR activity accompanied by overlap of the oxidant-antioxidant system.	Iron	141-145	transferrin	Homo sapiens	156-158
31621732-3	2019	This contribution discusses the use of triphenylphosphine (PPh3) as a molten flux to synthesize superconducting iron selenide (Fe1+deltaSe) at low temperature (T = 325  C).	Iron	127-138	caveolin 1	Homo sapiens	59-63
31621732-5	2019	Exploration of the Fe-Se-PPh3 phase space indicates that the PPh3-Se adduct effectively reduces the chemical potential of the selenium at high concentrations of triphenylphosphine.	Iron	19-24	caveolin 1	Homo sapiens	25-29
31621732-5	2019	Exploration of the Fe-Se-PPh3 phase space indicates that the PPh3-Se adduct effectively reduces the chemical potential of the selenium at high concentrations of triphenylphosphine.	Iron	19-24	caveolin 1	Homo sapiens	61-65
31543462-2	2019	Accumulated evidence has revealed that hepcidin, the master regulator of iron homeostasis, is negatively modulated by TMPRSS6 (matriptase-2), a liver-specific type II transmembrane serine protease (TTSP).	Iron	73-77	transmembrane serine protease 6	Homo sapiens	127-139
31573119-3	2019	Herein, we report a selective, practical and fast iron-based cross-coupling reaction which enables the formation of Csp-Csp3 and Csp2-Csp3 bonds.	Iron	50-54	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	116-119
31553151-7	2019	When NIR irradiation was given to CSO-BHQ-IR780-Hex/MIONPs/Sor-treated cells, iron supply increased, the xCT/GSH/GPX-4 system was triggered, and a lot of LPO burst.	Iron	78-82	hematopoietically expressed homeobox	Mus musculus	48-51
31563673-3	2019	Iron is imported into mitochondria by the two homologous Fe ion importers mitoferrin-1 and mitoferrin-2.	Iron	0-4	solute carrier family 25, member 37	Mus musculus	74-86
31563673-3	2019	Iron is imported into mitochondria by the two homologous Fe ion importers mitoferrin-1 and mitoferrin-2.	Iron	0-4	solute carrier family 25, member 28	Mus musculus	91-103
31563673-3	2019	Iron is imported into mitochondria by the two homologous Fe ion importers mitoferrin-1 and mitoferrin-2.	Iron	57-59	solute carrier family 25, member 37	Mus musculus	74-86
31563673-3	2019	Iron is imported into mitochondria by the two homologous Fe ion importers mitoferrin-1 and mitoferrin-2.	Iron	57-59	solute carrier family 25, member 28	Mus musculus	91-103
31573119-3	2019	Herein, we report a selective, practical and fast iron-based cross-coupling reaction which enables the formation of Csp-Csp3 and Csp2-Csp3 bonds.	Iron	50-54	regulator of calcineurin 2	Homo sapiens	129-133
31814879-0	2019	Sex-Specific Negative Association between Iron Intake and Cellular Aging Markers: Mediation Models Involving TNFalpha.	Iron	42-46	tumor necrosis factor	Homo sapiens	109-117
31554636-7	2019	Additionally, the HRI-eIF2alphaP-ATF4 pathway represses mechanistic target of rapamycin complex 1 (mTORC1) signaling, specifically in the erythroid lineage as a feedback mechanism of erythropoietin-stimulated erythropoiesis during iron/heme deficiency.	Iron	231-235	erythropoietin	Homo sapiens	183-197
31781327-0	2019	Iron Overload Damages the Endothelial Mitochondria via the ROS/ADMA/DDAHII/eNOS/NO Pathway.	Iron	0-4	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	68-74
31719592-10	2019	These levels remained suppressed to 48 h of age with some recovery by 96 h. Reductions in serum iron were associated with high hepcidin and IL-6 levels.	Iron	96-100	interleukin 6	Homo sapiens	140-144
31260980-7	2019	Working range (0.01-2 mug L-1 for Cd and 10-500 mug L-1 for Fe) was suitable for the determination of analytes in samples.	Iron	60-62	immunoglobulin kappa variable 1-16	Homo sapiens	52-55
31001623-11	2019	CONCLUSIONS: FE is a cell-free, easy-to-prepare, and growth-factor-enriched liquid derived from human adipose tissue that possesses proangiogenic activity and improves skin flap survival by accelerating blood vessel formation.	Iron	13-15	arachidonate 5-lipoxygenase activating protein	Homo sapiens	173-177
31724044-2	2019	Humans store iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and lactoferrin, limiting the availability of free iron for pathogenic bacteria.	Iron	13-17	haptoglobin	Homo sapiens	64-75
31724044-2	2019	Humans store iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and lactoferrin, limiting the availability of free iron for pathogenic bacteria.	Iron	13-17	transferrin	Homo sapiens	77-88
31713740-2	2019	Carbon-encapsulated iron nanoparticles were functionalized with bovine serum albumin, coupled to monoclonal antibodies, and then used as magnetic labels.	Iron	20-24	albumin	Homo sapiens	71-84
31814879-7	2019	The association between dietary iron intake and cellular aging markers and TNFalpha and superoxide dismutase (SOD) was analyzed by Pearson correlation analysis and regression models adjusted by covariates.	Iron	32-36	tumor necrosis factor	Homo sapiens	75-83
31814879-7	2019	The association between dietary iron intake and cellular aging markers and TNFalpha and superoxide dismutase (SOD) was analyzed by Pearson correlation analysis and regression models adjusted by covariates.	Iron	32-36	superoxide dismutase 1	Homo sapiens	88-108
31814879-8	2019	Simple mediation models were generated to examine whether TNFalpha mediated the association between iron intake and cellular aging markers using PROCESS macro Version 3.3.	Iron	100-104	tumor necrosis factor	Homo sapiens	58-66
31814879-12	2019	Moreover, iron intake was positively associated with TNFalpha in both women and men but positively associated with SOD only in men.	Iron	10-14	tumor necrosis factor	Homo sapiens	53-61
31814879-12	2019	Moreover, iron intake was positively associated with TNFalpha in both women and men but positively associated with SOD only in men.	Iron	10-14	superoxide dismutase 1	Homo sapiens	115-118
31814879-13	2019	Path modeling showed that TNFalpha significantly mediated the indirect detrimental effect of iron intake on LTL only in women; in men, mediation of the indirect effect of iron intake on mtDNAcn by TNFalpha did not reach significance.	Iron	93-97	tumor necrosis factor	Homo sapiens	26-34
31814879-14	2019	Conclusions: The study found sex-specific negative associations between dietary iron intake and cellular aging markers in that iron intake had deleterious effects on LTL attrition in women and mtDNAcn in men; only the former was partly mediated by TNFalpha.	Iron	80-84	tumor necrosis factor	Homo sapiens	248-256
31814879-14	2019	Conclusions: The study found sex-specific negative associations between dietary iron intake and cellular aging markers in that iron intake had deleterious effects on LTL attrition in women and mtDNAcn in men; only the former was partly mediated by TNFalpha.	Iron	127-131	tumor necrosis factor	Homo sapiens	248-256
31696027-10	2019	Furthermore, the up-regulation of TFRC gene expression in adhesive group supports its proposed role in activation of immune cells against E. coli and intracellular iron transport.	Iron	164-168	transferrin receptor	Sus scrofa	34-38
31763571-0	2019	Anti-CD34-Grafted Magnetic Nanoparticles Promote Endothelial Progenitor Cell Adhesion on an Iron Stent for Rapid Endothelialization.	Iron	92-96	CD34 molecule	Homo sapiens	5-9
31763571-3	2019	The objective of this study is to demonstrate the feasibility of using endothelial progenitor cells (EPCs) to rapidly adhere onto iron surfaces with the assistance of anti-CD34-modified magnetic nanoparticles.	Iron	130-134	CD34 molecule	Homo sapiens	172-176
31603317-8	2019	The reactive oxidants produced at 30 mA (or 60 mA/L) could degrade about 47% of 10 muM aniline and 34% of sulfanilamide within 6 h of Fe EC treatment.	Iron	134-136	latexin	Homo sapiens	83-86
31787896-4	2019	Here, we used a PAE rat model to analyze messenger RNA (mRNA) and protein expression of iron homeostasis genes such as transferrin receptor (TfR), divalent metal transporter (DMT1), ferroportin (FPN1), and ferritin (FT) in brain areas associated with memory formation such as the prefrontal cortex (PFC), ventral tegmental area, and hippocampus.	Iron	88-92	solute carrier family 40 member 1	Rattus norvegicus	195-199
31694285-0	2019	GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload.	Iron	69-73	glutathione S-transferase mu 1	Homo sapiens	0-5
31694285-3	2019	We evaluated the association of the copy number of the glutathione S-transferase M1 (GSTM1) gene and degree of iron overload among patients with SCA.	Iron	111-115	glutathione S-transferase mu 1	Homo sapiens	55-83
31694285-3	2019	We evaluated the association of the copy number of the glutathione S-transferase M1 (GSTM1) gene and degree of iron overload among patients with SCA.	Iron	111-115	glutathione S-transferase mu 1	Homo sapiens	85-90
31694285-8	2019	GSTM1 homozygous deletion may prevent effective chelation in children with SCA and iron overload.	Iron	83-87	glutathione S-transferase mu 1	Homo sapiens	0-5
31524964-0	2019	Alcohol"s dysregulation of maternal-fetal IL-6 and p-STAT3 is a function of maternal iron status.	Iron	85-89	interleukin 6	Rattus norvegicus	42-46
31524964-4	2019	Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3.	Iron	26-30	hepcidin antimicrobial peptide	Rattus norvegicus	98-106
31524964-4	2019	Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3.	Iron	26-30	bone morphogenetic protein 6	Rattus norvegicus	124-128
31524964-4	2019	Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3.	Iron	26-30	interleukin 6	Rattus norvegicus	138-142
31524964-11	2019	Dietary iron fortification sharply attenuated Il-6 expression in response to PAE, with IF driving a 150-fold decrease (P&lt;0.001) in maternal liver and a 10-fold decrease (P&lt;0.01) in fetal liver.	Iron	8-12	interleukin 6	Rattus norvegicus	46-50
31542426-0	2019	Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway.	Iron	0-4	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	56-60
31344531-6	2019	By 2D NMR, we confirmed that iron can be bound in both oxidation states, a controversial issue, and, in addition, we were able to point out a transient interaction of frataxin with a N-terminal 6his-tagged variant of ISCU, the scaffold protein of the FeS clusters assembly machinery.	Iron	29-33	iron-sulfur cluster assembly enzyme	Homo sapiens	217-221
31472185-12	2019	Meanwhile, PRO suppressed the inflammatory response through inhibiting IL-6 and Cox2 expression and activating JAK/STAT3 signaling induced by iron overload.	Iron	142-146	signal transducer and activator of transcription 3	Homo sapiens	115-120
31472185-14	2019	PRO could protect against nerve cell injury induced by overload of iron through regulating iron metabolism and inhibiting stress oxidative and inflammation reaction pathways by targeting JAK/STAT3 signaling.	Iron	67-71	signal transducer and activator of transcription 3	Homo sapiens	191-196
31472186-0	2019	Dehydroepiandrosterone alleviates oxidative stress and apoptosis in iron-induced epilepsy via activation of Nrf2/ARE signal pathway.	Iron	68-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
31474326-8	2019	In a subgroup of ferropenic patients (n = 56), treatment with intravenous iron before TAVI was feasible, resulting in a considerable improvement of ferritin, transferrin saturation and symptoms at 30-day follow-up.	Iron	74-78	transferrin	Homo sapiens	158-169
31499027-1	2019	Lactoferrin (LTF) is an iron-binding protein canonically known for its innate and adaptive immune functions.	Iron	24-28	lactotransferrin	Homo sapiens	0-11
31499027-1	2019	Lactoferrin (LTF) is an iron-binding protein canonically known for its innate and adaptive immune functions.	Iron	24-28	lactotransferrin	Homo sapiens	13-16
31419721-2	2019	It mediates cellular iron import through a constitutive clathrin-dependent endocytosis mechanism and by recruiting iron- regulator proteins as transferrin, Hereditary Hemochromatosis factor (HFE) and serum ferritin in response to cellular demand.	Iron	115-119	transferrin	Homo sapiens	143-154
31472185-8	2019	Our results showed low concentration of PRO (5 muM) could significantly prevent FAC induced apoptosis via inhibiting oxidative stress and iron accumulation.	Iron	138-142	FA complementation group C	Homo sapiens	80-83
31472186-9	2019	In conclusion, our findings demonstrate that neuroprotective effect of DHEA against iron-induced epilepsy might be escorted by the alleviation of oxidative stress through Nrf2-mediated signal pathway.	Iron	84-88	NFE2 like bZIP transcription factor 2	Rattus norvegicus	171-175
31542426-13	2019	Moreover, iron deposition up-regulated the expression of AMPK, Beclin1 and LC3 and increase the number of autophagosomes in hippocampus.	Iron	10-14	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	57-61
31542426-14	2019	And the expression of Bax was up-regulated and Bcl-2 was down-regulated in iron deposition groups.	Iron	75-79	BCL2, apoptosis regulator	Rattus norvegicus	47-52
31542426-15	2019	To sum up, our data suggested that iron deposition increased AMPK/autophagy pathway associated molecules in the hippocampus and promoted neuronal apoptosis, which might be a new pathogenesis in vascular dementia.	Iron	35-39	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	61-65
31437646-11	2019	Considering that the high content of Al2O3 and Fe-species in the biochar composite imparts a strong affinity for As(V), the practical use of the biochar composite as a sorptive material for arsenic (V) was evaluated at the fundamental levels.	Iron	47-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	113-118
31203045-3	2019	Four 370-day lab-scale permeable reactive barrier experiments with four SCCMs showed that NO3- removal efficiency in zero-valent iron (ZVI) SCCMs was higher than in ZVI-free SCCMs.	Iron	129-133	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
31203045-3	2019	Four 370-day lab-scale permeable reactive barrier experiments with four SCCMs showed that NO3- removal efficiency in zero-valent iron (ZVI) SCCMs was higher than in ZVI-free SCCMs.	Iron	135-138	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
31203045-3	2019	Four 370-day lab-scale permeable reactive barrier experiments with four SCCMs showed that NO3- removal efficiency in zero-valent iron (ZVI) SCCMs was higher than in ZVI-free SCCMs.	Iron	165-168	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
31203045-4	2019	In the ZVI SCCMs, the NO3- removal reaction began quickly in the early stage, owing to ZVI chemical reduction, whereas biological denitrification was lower and incomplete with a NO2- concentration of 0.8 mg L-1 in the ZVI SCCM system.	Iron	7-10	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
31203045-4	2019	In the ZVI SCCMs, the NO3- removal reaction began quickly in the early stage, owing to ZVI chemical reduction, whereas biological denitrification was lower and incomplete with a NO2- concentration of 0.8 mg L-1 in the ZVI SCCM system.	Iron	87-90	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
31203045-4	2019	In the ZVI SCCMs, the NO3- removal reaction began quickly in the early stage, owing to ZVI chemical reduction, whereas biological denitrification was lower and incomplete with a NO2- concentration of 0.8 mg L-1 in the ZVI SCCM system.	Iron	87-90	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
31466145-2	2019	Coupled system showed the highest total nitrogen (TN) removal efficiency of 67.85% with the addition of 15 g L-1 iron shavings at pH 7.0, which was higher than 29.62% in the mono-ZVI system and 43.86% in the mono-cell system.	Iron	113-117	L1 cell adhesion molecule	Homo sapiens	109-112
29911470-4	2019	Using induced pluripotent stem cell (iPSC)-derived brain endothelial cells (huECs) as a human BBB model, we demonstrate the ability of transferrin, hepcidin, and DMT1 to impact iron transport and release.	Iron	177-181	transferrin	Homo sapiens	135-146
29911470-6	2019	We show that huECs secrete both transferrin and H-ferritin, which can serve as iron sources for the brain.	Iron	79-83	transferrin	Homo sapiens	32-43
31634513-7	2019	Mechanistically, DSP-4 increased iron content in hippocampus by disrupting the balance of iron release protein ferroportin 1 (Fpn-1) and transferrin receptor (TFR) in paraquat and maneb-treated mice.	Iron	90-94	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	111-124
31634513-7	2019	Mechanistically, DSP-4 increased iron content in hippocampus by disrupting the balance of iron release protein ferroportin 1 (Fpn-1) and transferrin receptor (TFR) in paraquat and maneb-treated mice.	Iron	90-94	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	126-131
31279900-7	2019	Upregulation of HO1 by NH4Cl triggered ER stress and was associated with elevated levels of free ferrous iron and expression changes in iron metabolism-related genes, which were largely abolished after knockdown or inhibition of GS, GFAT1/2, HO1 or iron chelation.	Iron	136-140	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	233-240
31076252-6	2019	When iron is limited, iron response element binding protein 2 (IRP2) binds to the IRE of ALAS2 mRNA and suppresses its translation.	Iron	5-9	iron responsive element binding protein 2	Homo sapiens	63-67
31076252-6	2019	When iron is limited, iron response element binding protein 2 (IRP2) binds to the IRE of ALAS2 mRNA and suppresses its translation.	Iron	22-26	iron responsive element binding protein 2	Homo sapiens	63-67
31455889-3	2019	The haemoprotein scavengers haptoglobin and haemopexin act to limit circulating levels of free haemoglobin, haem and iron - potentially toxic species that are released from injured RBCs.	Iron	117-121	haptoglobin	Homo sapiens	28-39
31466145-3	2019	Besides, the activities of nitrate reductase (NAR), nitrite reductase (NIR), nitric oxide reductase (NOR) and nitrous oxide reductase (N2OR) were significantly improved at ZVI dosage of 15 g L-1 and pH 7.0, which contributed to the higher TN removal efficiency in coupled system.	Iron	172-175	L1 cell adhesion molecule	Homo sapiens	191-194
31898571-24	2019	Def pretreatment could significantly reduce iron deposition and ferroptosis in hippocampal neurons of SAE rats and improve cognitive dysfunction, which may be related to activation of Nrf2/GPX4 signaling pathway.	Iron	44-48	UTP25 small subunit processome component	Rattus norvegicus	0-3
31439541-9	2019	These data are consistent with a model in which low iron in the marrow environment affects MEP metabolism, attenuates ERK signaling, slows proliferation, and biases MEP toward Mk lineage commitment.	Iron	52-56	mitogen-activated protein kinase 1	Mus musculus	118-121
31628297-0	2019	Qizhufang (ZSF) Ameliorates Hepatic Iron Overload via Signal Transducer and Activator of Transcription 3 (STAT3) Pathway.	Iron	36-40	signal transducer and activator of transcription 3	Homo sapiens	106-111
31653872-5	2019	A GDE is used to generate oxidants and hydroxide in-situ, enabling the oxidative synthesis of a single iron salt (e.g., FeCl2) into nanoparticles.	Iron	103-107	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	2-5
31652826-3	2019	Furthermore, due to the effective quenching effect of Fe3+ ions, the prepared N-CQDs can be used as a fluorescent sensor for Fe3+ ion-sensitive detection with a detection limit of 0.15 muM.	Iron	54-58	latexin	Homo sapiens	185-188
31652826-3	2019	Furthermore, due to the effective quenching effect of Fe3+ ions, the prepared N-CQDs can be used as a fluorescent sensor for Fe3+ ion-sensitive detection with a detection limit of 0.15 muM.	Iron	125-129	latexin	Homo sapiens	185-188
31411806-2	2019	Herein, a novel hybrid non-noble iron-based nanocatalyst (named as FeS2 /NSC) was developed, which was prepared from biomass as C and N source together with inexpensive Fe(NO3 )3 as Fe source through high-temperature pyrolysis in a straightforward and cost-effective procedure.	Iron	33-37	NBL1, DAN family BMP antagonist	Homo sapiens	172-175
31411806-2	2019	Herein, a novel hybrid non-noble iron-based nanocatalyst (named as FeS2 /NSC) was developed, which was prepared from biomass as C and N source together with inexpensive Fe(NO3 )3 as Fe source through high-temperature pyrolysis in a straightforward and cost-effective procedure.	Iron	67-69	NBL1, DAN family BMP antagonist	Homo sapiens	172-175
31686980-11	2019	Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day.	Iron	125-129	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31619722-9	2019	Multivariable analysis revealed that iron status and hemoglobin levels were major determinants of EPO levels.	Iron	37-41	erythropoietin	Homo sapiens	98-101
31619722-15	2019	Low EPO levels, especially when accompanied by poor iron status, are predictive of rapid loss of renal function.	Iron	52-56	erythropoietin	Homo sapiens	4-7
31658742-7	2019	Iron and copper were coordinated by the same N-terminal region of Abeta, likely through histidine residues.	Iron	0-4	amyloid beta precursor protein	Homo sapiens	66-71
31513388-1	2019	Oxoiron(IV) is a common catalytic byproduct observed in the oxidation of alkenes by the combination of H2O2 and nonheme iron catalysts including complex 1, FeIIPDP* (where PDP* = bis(3,5-dimethyl-4-methoxypyridyl-2-methyl)-(R,R)-2,2"-bipyrrolidine).	Iron	3-7	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	160-164
31363876-1	2019	Ferritin is a ubiquitous iron storage protein which plays key role in regulating iron homeostasis and metabolism.	Iron	25-29	ferritin	Bombyx mori	0-8
31441223-4	2019	Mechanistically, we show that iron overload leads to a decrease in Akt-mediated repression of tuberous sclerosis complex (TSC2) and Rheb-mediated mTORC1 activation on autolysosomes, thereby inhibiting autophagic-lysosome regeneration.	Iron	30-34	thymoma viral proto-oncogene 1	Mus musculus	67-70
31287223-2	2019	The DDX11 gene codes for an iron-sulfur DNA helicase in the Superfamily 2 helicases and plays an important role in genomic stability and maintenance.	Iron	28-32	DEAD/H-box helicase 11	Homo sapiens	4-9
31363876-1	2019	Ferritin is a ubiquitous iron storage protein which plays key role in regulating iron homeostasis and metabolism.	Iron	81-85	ferritin	Bombyx mori	0-8
31363876-8	2019	Finally, the refolded ferritin had the ability to store iron, exhibited ferroxidase activity, and could withstand high temperatures and pH treatment, which is consistent with ferritin in other species.	Iron	56-60	ferritin	Bombyx mori	22-30
31172340-0	2019	Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells.	Iron	69-73	C-X3-C motif chemokine ligand 1	Homo sapiens	0-11
31152902-4	2019	The results demonstrated that the dewaterability of aerobically digested sludge could be significantly enhanced with the PS and ZVI dosage in the range of 0-0.5 g/gTS and 0-0.4 g/gTS, respectively.	Iron	128-131	GTS	Homo sapiens	163-166
31152902-4	2019	The results demonstrated that the dewaterability of aerobically digested sludge could be significantly enhanced with the PS and ZVI dosage in the range of 0-0.5 g/gTS and 0-0.4 g/gTS, respectively.	Iron	128-131	GTS	Homo sapiens	179-182
31172340-9	2019	Moreover, fractalkine-induced hepcidin production of microglia initiated ferroportin internalisation of SH-SY5Y cells, which contributed to iron accumulation of neurons.	Iron	140-144	C-X3-C motif chemokine ligand 1	Homo sapiens	10-21
31172340-11	2019	Moreover, fractalkine indirectly contributes to the iron accumulation of SH-SY5Y cells by activating ferroportin internalisation and by triggering the expressions of divalent metal transporter-1, ferritin heavy chain and mitochondrial ferritin.	Iron	52-56	C-X3-C motif chemokine ligand 1	Homo sapiens	10-21
30660761-0	2019	Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-alpha using 1H MR spectroscopy and MRI.	Iron	61-65	insulin	Homo sapiens	0-7
31330363-8	2019	Nine constituents (OC, EC, K, Fe, Zn, Ba, Cr, Se, and Pb) showed consistent associations with elevated FeNO and decreased NOS2A methylation or increased ARG2 methylation in single-constituent models and models adjusting for PM2.5 total mass and collinearity.	Iron	30-32	nitric oxide synthase 2	Homo sapiens	122-127
31485910-1	2019	BACKGROUND: Parental iron is used to optimize hemoglobin and enhance erythropoiesis in end-stage renal disease along with erythropoietin-stimulating agents.	Iron	21-25	erythropoietin	Homo sapiens	122-136
31542425-5	2019	One of these carriers (TbMCP17) displayed high similarity with the iron carriers MRS3, MRS4 from yeast and mitoferrin from mammals, insects and plants.	Iron	67-71	Fe(2+) transporter	Saccharomyces cerevisiae S288C	81-85
31229782-2	2019	Concentrations of Cd, Co, Cu, Fe, Mn, Ni, Pb and V in TSP and PM10 were determined by inductively coupled plasma mass spectrometry (ICP-MS).	Iron	30-32	thrombospondin 1	Homo sapiens	54-57
31889039-3	2019	Due to the high need for iron in many disorders including various types of cancer, iron-binding proteins: transferrin, ferritin and hemoglobin, are a promising tool as drug carriers.	Iron	25-29	transferrin	Homo sapiens	106-117
31889039-3	2019	Due to the high need for iron in many disorders including various types of cancer, iron-binding proteins: transferrin, ferritin and hemoglobin, are a promising tool as drug carriers.	Iron	83-87	transferrin	Homo sapiens	106-117
31542425-6	2019	In the present study we demonstrated that TbMCP17 functions as an iron carrier by complementation studies using MRS3/4-deficient yeast.	Iron	66-70	Fe(2+) transporter	Saccharomyces cerevisiae S288C	112-118
31373885-5	2019	However, the association of all significant FABP4 markers with FE and milk content traits was found in opposite directions, such that improved FE was accompanied by decreased milk content.	Iron	63-65	fatty acid-binding protein, adipocyte	Bos taurus	44-49
31373885-5	2019	However, the association of all significant FABP4 markers with FE and milk content traits was found in opposite directions, such that improved FE was accompanied by decreased milk content.	Iron	143-145	fatty acid-binding protein, adipocyte	Bos taurus	44-49
31413226-6	2019	Cyanobacteria are abundant and active even at ferrous iron concentrations of ~150 muM, which challenges the idea that iron toxicity limited cyanobacterial expansion in Precambrian oceans.	Iron	54-58	latexin	Homo sapiens	82-85
31466010-0	2019	Epileptic encephalopathy and brain iron accumulation due to WDR45 mutation.	Iron	35-39	WD repeat domain 45	Homo sapiens	60-65
31168664-7	2019	NH4+ also increases soluble Fe levels in shoots by upregulating genes involved in Fe translocation, such as FRD3 (FERRIC REDUCTASE DEFECTIVE3) and NAS1 (NICOTIANAMINE SYNTHASE1), hence, alleviating leaf chlorosis.	Iron	28-30	MATE efflux family protein	Arabidopsis thaliana	108-112
31168664-7	2019	NH4+ also increases soluble Fe levels in shoots by upregulating genes involved in Fe translocation, such as FRD3 (FERRIC REDUCTASE DEFECTIVE3) and NAS1 (NICOTIANAMINE SYNTHASE1), hence, alleviating leaf chlorosis.	Iron	28-30	MATE efflux family protein	Arabidopsis thaliana	114-141
31238089-9	2019	Supplementation of transferrin-bound iron recovered osteoclastogenesis.	Iron	37-41	transferrin	Homo sapiens	19-30
31238089-10	2019	Iron chelation resulted in a marked decrease in ferritin level, and increased expression of transferrin receptor 1 and ferroportin.	Iron	0-4	transferrin	Homo sapiens	92-103
31511419-3	2019	The structural and functional core of the Fe-S cluster assembly complex is a low-activity pyridoxal 5"-phosphate (PLP)-dependent cysteine desulfurase enzyme that consists of catalytic (NFS1), LYRM protein (ISD11), and acyl carrier protein (ACP) subunits.	Iron	42-46	LYR motif containing 4	Homo sapiens	206-211
31554201-7	2019	Additionally, tail-vein injection of miR-20b resulted in increasing duodenal miR-20b expression, decreasing duodenal FPN protein expression, which was closely related to lower plasma iron level in mice.	Iron	183-187	microRNA 20b	Mus musculus	37-44
31554201-8	2019	Taken together, these data suggest that the miR-20b is identified to regulate intestinal FPN expression in vitro and in vivo, which will provide a potential target for intestinal iron exportation.	Iron	179-183	microRNA 20b	Mus musculus	44-51
31540540-9	2019	Protein network interaction and gene function analyses revealed that SLC2A2 was an important candidate gene for FE in pigs, which may give us a deeper understanding of the mechanism of feed efficiency.	Iron	112-114	solute carrier family 2 member 2	Sus scrofa	69-75
31432676-6	2019	Whereas for M = Ni (DeltaE = -13 kcal/mol) Ni+III is reduced to Ni+II, for M = Co, Fe, Mn (DeltaE = 1, 10, 6 kcal/mol, respectively) it is Co+III that is reduced to Co+II.	Iron	83-85	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	139-145
31432676-6	2019	Whereas for M = Ni (DeltaE = -13 kcal/mol) Ni+III is reduced to Ni+II, for M = Co, Fe, Mn (DeltaE = 1, 10, 6 kcal/mol, respectively) it is Co+III that is reduced to Co+II.	Iron	83-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31532389-3	2019	In C. elegans, iron uptake and sequestration are regulated by HIF-1.	Iron	15-19	Hypoxia-inducible factor 1	Caenorhabditis elegans	62-67
31532389-4	2019	We previously showed that hif-1 mutants are developmentally delayed when grown under iron limitation.	Iron	85-89	Hypoxia-inducible factor 1	Caenorhabditis elegans	26-31
31532389-5	2019	Here we identify nhr-14, encoding a nuclear receptor, in a screen conducted for mutations that rescue the developmental delay of hif-1 mutants under iron limitation.	Iron	149-153	Hypoxia-inducible factor 1	Caenorhabditis elegans	129-134
31532389-6	2019	nhr-14 loss upregulates the intestinal metal transporter SMF-3 to increase iron uptake in hif-1 mutants.	Iron	75-79	Hypoxia-inducible factor 1	Caenorhabditis elegans	90-95
31448589-3	2019	Chemical reduction in the presence of PPh3 resulted in a diamagnetic, folded ligand complex with an Fe-Fe bonding interaction (dFe-Fe = 2.7096(17) A) between two intermediate spin (SFe = 1) Fe(II) centers.	Iron	100-102	caveolin 1	Homo sapiens	38-42
31421070-6	2019	In fact, HO1, NADPH-cytochrome P450 reductase, and PCBP2 form a functional unit that integrates the catabolism of heme with the binding and transport of iron by PCBP2.	Iron	153-157	cytochrome p450 oxidoreductase	Homo sapiens	14-45
31421070-6	2019	In fact, HO1, NADPH-cytochrome P450 reductase, and PCBP2 form a functional unit that integrates the catabolism of heme with the binding and transport of iron by PCBP2.	Iron	153-157	poly(rC) binding protein 2	Homo sapiens	51-56
31421070-0	2019	How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2.	Iron	4-8	poly(rC) binding protein 2	Homo sapiens	141-168
31421070-0	2019	How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2.	Iron	103-107	poly(rC) binding protein 2	Homo sapiens	141-168
31421070-6	2019	In fact, HO1, NADPH-cytochrome P450 reductase, and PCBP2 form a functional unit that integrates the catabolism of heme with the binding and transport of iron by PCBP2.	Iron	153-157	poly(rC) binding protein 2	Homo sapiens	161-166
31421070-5	2019	Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport.	Iron	28-32	poly(rC) binding protein 2	Homo sapiens	44-71
31421070-5	2019	Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport.	Iron	28-32	poly(rC) binding protein 2	Homo sapiens	73-78
31210010-0	2019	Visible-Light-Promoted Iron-Catalyzed C(sp2 )-C(sp3 ) Kumada Cross-Coupling in Flow.	Iron	23-27	Sp2 transcription factor	Homo sapiens	38-43
31421070-5	2019	Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport.	Iron	137-141	poly(rC) binding protein 2	Homo sapiens	44-71
31421070-5	2019	Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport.	Iron	137-141	poly(rC) binding protein 2	Homo sapiens	73-78
31421070-5	2019	Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport.	Iron	137-141	poly(rC) binding protein 2	Homo sapiens	44-71
31421070-5	2019	Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport.	Iron	137-141	poly(rC) binding protein 2	Homo sapiens	73-78
31433635-3	2019	In this study, inoculation with Enterobacter asburiae NC16 reduced transpiration rates and the expression of some iron (Fe) uptake-related genes including ZmFer, ZmYS1, ZmZIP, and ZmNAS2 in maize (Zea mays) plants, which contributed to mitigation of Cd toxicity.	Iron	114-118	nicotianamine synthase 2	Zea mays	180-186
31433635-3	2019	In this study, inoculation with Enterobacter asburiae NC16 reduced transpiration rates and the expression of some iron (Fe) uptake-related genes including ZmFer, ZmYS1, ZmZIP, and ZmNAS2 in maize (Zea mays) plants, which contributed to mitigation of Cd toxicity.	Iron	120-122	nicotianamine synthase 2	Zea mays	180-186
31356905-0	2019	Chronic iron overload intensifies atherosclerosis in apolipoprotein E deficient mice: Role of oxidative stress and endothelial dysfunction.	Iron	8-12	apolipoprotein E	Mus musculus	53-69
31356905-3	2019	Here, we have tested the hypothesis that chronic iron overload may change vascular reactivity associated with worsening of the atherosclerotic process in apolipoprotein E knockout (apoE(-/-)) mice.	Iron	49-53	apolipoprotein E	Mus musculus	154-170
31356905-6	2019	By scanning electron microscopy, the small endothelial structural damage caused by iron in WT was worsened in the apoE(-/-) group.	Iron	83-87	apolipoprotein E	Mus musculus	114-118
31540266-5	2019	Superoxide dismutase and peroxidase isoenzymatic regulation may play a determinant role: 10 superoxide dismutase isoenzymes were observed in both cultivars, but iron superoxide dismutase activity was only detected in efficient plants; 15 peroxidase isoenzymes were observed in the roots and trifoliate leaves of efficient and inefficient cultivars and peroxidase activity levels were only increased in roots of efficient plants.	Iron	161-165	peroxidase	Glycine max	25-35
31511561-6	2019	Knockdown of ABCB7 in H9C2 cells and stimulation with angiotensin II resulted in increased ROS levels, ferritin, and transferrin receptor expression and iron overload in both mitochondria and cytoplasm.	Iron	153-157	angiotensinogen	Rattus norvegicus	54-68
31572837-11	2019	Spectroscopic data showed that the obtained carbon dots can detect Fe3+ ions within the wide concentration range of 30-600 muM with 9.55 muM detection limit.	Iron	67-71	latexin	Homo sapiens	123-126
31381310-3	2019	Fe-bearing nanoparticles (&lt;0.1 mum) in urban environments may be especially important because of their pathogenicity and possible association with neurodegenerative diseases, such as Alzheimer"s and Parkinson"s diseases.	Iron	0-2	latexin	Homo sapiens	34-37
31572837-11	2019	Spectroscopic data showed that the obtained carbon dots can detect Fe3+ ions within the wide concentration range of 30-600 muM with 9.55 muM detection limit.	Iron	67-71	latexin	Homo sapiens	137-140
31315930-6	2019	Manipulation of heparan sulfate had a similar effect on IL6-dependent hepcidin expression in vitro and suppressed IL6-mediated iron redistribution induced by lipopolysaccharide in vivo These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.	Iron	127-131	interleukin 6	Mus musculus	114-117
31315930-6	2019	Manipulation of heparan sulfate had a similar effect on IL6-dependent hepcidin expression in vitro and suppressed IL6-mediated iron redistribution induced by lipopolysaccharide in vivo These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.	Iron	314-318	interleukin 6	Mus musculus	114-117
31483921-0	2020	Iron Infusion And Induced Hypophosphatemia: The Role Of FGF2.	Iron	0-4	fibroblast growth factor 2	Homo sapiens	56-60
31500291-0	2019	Distinct TP53 Mutation Subtypes Differentially Influence Cellular Iron Metabolism.	Iron	66-70	tumor protein p53	Homo sapiens	9-13
31500291-1	2019	The most commonly mutated gene in all human cancers is the tumor suppressor gene TP53; however, in addition to the loss of tumor suppressor functions, mutations in TP53 can also promote cancer progression by altering cellular iron acquisition and metabolism.	Iron	226-230	tumor protein p53	Homo sapiens	81-85
31500291-1	2019	The most commonly mutated gene in all human cancers is the tumor suppressor gene TP53; however, in addition to the loss of tumor suppressor functions, mutations in TP53 can also promote cancer progression by altering cellular iron acquisition and metabolism.	Iron	226-230	tumor protein p53	Homo sapiens	164-168
31500291-2	2019	The primary objective of this work was to determine how TP53 mutation status influences the molecular control of iron homeostasis.	Iron	113-117	tumor protein p53	Homo sapiens	56-60
31500291-4	2019	The introduction of distinct TP53 mutation types alone was sufficient to disrupt cellular iron metabolism.	Iron	90-94	tumor protein p53	Homo sapiens	29-33
31500291-7	2019	In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type.	Iron	26-30	tumor protein p53	Homo sapiens	80-84
31500291-7	2019	In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type.	Iron	26-30	tumor protein p53	Homo sapiens	94-98
31500291-9	2019	These findings suggest a novel, IRP-independent mode of iron regulation in cells expressing distinct TP53 mutations.	Iron	56-60	tumor protein p53	Homo sapiens	101-105
31491970-0	2019	Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper.	Iron	52-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
31491970-7	2019	Experiments revealed that the Nrf2 knockout partially affected the trace element concentrations of Cu, Zn, Fe, or Se in the intestine, liver, and/or plasma.	Iron	107-109	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
31484461-6	2019	In multivariable linear regression analyses, PPI use was inversely associated with serum iron (beta = -1.61, p = 0.001), natural log transformed serum ferritin (beta&amp;nbsp;= -0.31, p &lt; 0.001), TSAT (beta = -2.85, p = 0.001), and hemoglobin levels (beta = -0.35, p = 0.007), independent of potential confounders.	Iron	89-93	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	95-104
31381310-5	2019	We focus on data reported for the following sources of Fe-bearing nanoparticles: exhaust emissions (both diesel and gasoline), brake wear, tire and road surface wear, resuspension of roadside dust, underground, train and tram emissions, and aircraft and shipping emissions.	Iron	55-57	translocation associated membrane protein 1	Homo sapiens	221-225
31229492-8	2019	ROS produced by iron activates various signalling pathways, including mitogen-activated protein kinase (MAPK) signalling pathways such as the apoptosis signal-regulating kinase 1 (ASK1)-p38/JNK pathway.	Iron	16-20	mitogen-activated protein kinase 8	Homo sapiens	190-193
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	retinoid X receptor gamma	Sus scrofa	263-267
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	LIM homeobox 4	Sus scrofa	287-291
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	mastermind-like 2	Sus scrofa	293-298
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	nuclear factor of activated T cells 3	Sus scrofa	300-306
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	transcription elongation factor A1	Sus scrofa	316-321
31229649-6	2019	Domain-swapping experiments between dZIP7 (CG10449/ Catsup) and dZIP13 suggest that the N-terminus of dZIP13 is necessary to mediate this iron regulatory process.	Iron	138-142	Catecholamines up	Drosophila melanogaster	52-58
31493153-0	2019	The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2.	Iron	37-41	Aft2p	Saccharomyces cerevisiae S288C	52-56
31366990-4	2019	In particular, NDUFAB1 not only serves as a complex I subunit, but also coordinates the assembly of respiratory complexes I, II, and III, and supercomplexes, through regulating iron-sulfur biosynthesis and complex I subunit stability.	Iron	177-181	NADH:ubiquinone oxidoreductase subunit AB1	Mus musculus	15-22
31260634-0	2019	Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality.	Iron	107-111	period circadian clock 2	Mus musculus	10-18
31233777-9	2019	A prominent role of alpha-synuclein in iron homeostasis is involved in the uptake of transferrin-Fe.	Iron	39-43	transferrin	Homo sapiens	85-96
31233777-9	2019	A prominent role of alpha-synuclein in iron homeostasis is involved in the uptake of transferrin-Fe.	Iron	97-99	transferrin	Homo sapiens	85-96
31493153-7	2019	Loss of either cysteine in the Aft2 iron-sulfur binding site may disrupt this ligand-exchange process leading to the isolation of a trapped Aft2-Grx3-Bol2 intermediate, while the replacement of both cysteines abrogates both the iron-sulfur cluster exchange and the protein-protein interactions between Aft2 and Grx3-Bol2.	Iron	228-232	Aft2p	Saccharomyces cerevisiae S288C	31-35
31493153-0	2019	The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2.	Iron	66-70	Aft2p	Saccharomyces cerevisiae S288C	52-56
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	92-96	Aft2p	Saccharomyces cerevisiae S288C	76-80
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	160-164	Aft2p	Saccharomyces cerevisiae S288C	76-80
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	160-164	Aft2p	Saccharomyces cerevisiae S288C	76-80
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	160-164	Aft2p	Saccharomyces cerevisiae S288C	76-80
31493153-2	2019	Conversely, when iron levels are sufficient, Aft1 and Aft2 interact with the cytosolic glutaredoxins Grx3 and Grx4 and the BolA protein Bol2, which promote Aft1/2 dissociation from DNA and subsequent export from the nucleus.	Iron	17-21	Aft2p	Saccharomyces cerevisiae S288C	54-58
31493153-2	2019	Conversely, when iron levels are sufficient, Aft1 and Aft2 interact with the cytosolic glutaredoxins Grx3 and Grx4 and the BolA protein Bol2, which promote Aft1/2 dissociation from DNA and subsequent export from the nucleus.	Iron	17-21	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	110-114
31493153-3	2019	Previous studies unveiled the molecular mechanism for iron-dependent inhibition of Aft1/2 activity, demonstrating that the [2Fe-2S]-bridged Grx3-Bol2 heterodimer transfers a cluster to Aft2, driving Aft2 dimerization and dissociation from DNA.	Iron	54-58	Aft2p	Saccharomyces cerevisiae S288C	185-189
31493153-3	2019	Previous studies unveiled the molecular mechanism for iron-dependent inhibition of Aft1/2 activity, demonstrating that the [2Fe-2S]-bridged Grx3-Bol2 heterodimer transfers a cluster to Aft2, driving Aft2 dimerization and dissociation from DNA.	Iron	54-58	Aft2p	Saccharomyces cerevisiae S288C	199-203
31493153-4	2019	Here, we provide further insight into the regulation mechanism by investigating the roles of conserved cysteines in Aft2 in iron-sulfur cluster binding and interaction with [2Fe-2S]-Grx3-Bol2.	Iron	124-128	Aft2p	Saccharomyces cerevisiae S288C	116-120
31493153-6	2019	Taken together, these results provide novel insight into the molecular details of iron-sulfur cluster transfer from Grx3-Bol2 to Aft2 which likely occurs through a ligand exchange mechanism.	Iron	82-86	Aft2p	Saccharomyces cerevisiae S288C	129-133
31493153-7	2019	Loss of either cysteine in the Aft2 iron-sulfur binding site may disrupt this ligand-exchange process leading to the isolation of a trapped Aft2-Grx3-Bol2 intermediate, while the replacement of both cysteines abrogates both the iron-sulfur cluster exchange and the protein-protein interactions between Aft2 and Grx3-Bol2.	Iron	36-40	Aft2p	Saccharomyces cerevisiae S288C	31-35
31493153-7	2019	Loss of either cysteine in the Aft2 iron-sulfur binding site may disrupt this ligand-exchange process leading to the isolation of a trapped Aft2-Grx3-Bol2 intermediate, while the replacement of both cysteines abrogates both the iron-sulfur cluster exchange and the protein-protein interactions between Aft2 and Grx3-Bol2.	Iron	36-40	Aft2p	Saccharomyces cerevisiae S288C	140-144
31493153-7	2019	Loss of either cysteine in the Aft2 iron-sulfur binding site may disrupt this ligand-exchange process leading to the isolation of a trapped Aft2-Grx3-Bol2 intermediate, while the replacement of both cysteines abrogates both the iron-sulfur cluster exchange and the protein-protein interactions between Aft2 and Grx3-Bol2.	Iron	36-40	Aft2p	Saccharomyces cerevisiae S288C	140-144
31078097-0	2019	Influence of fulvic acid on Pb(II) removal from water using a post-synthetically modified MIL-100(Fe).	Iron	98-100	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
31078097-9	2019	Increasing FA concentration steadily increased the functional groups surrounding the ED-MIL-100(Fe) via electrical interaction, thus facilitating the Pb(II) ions adsorption.	Iron	96-98	submaxillary gland androgen regulated protein 3B	Homo sapiens	150-156
31368136-2	2019	Perinatal iron deficient male offspring exhibit enhanced conversion of big endothelin-1 to active endothelin-1, coinciding with decreased nitric oxide levels.	Iron	10-14	endothelin 1	Rattus norvegicus	75-87
31220756-2	2019	Heme regulatory motifs (HRMs) are conserved in the two IRP homologues IRP1 and IRP2 that specifically bind to two and three heme equivalents, respectively; however, only the heme binding to the iron-dependent degradation (IDD) domain of IRP2 causes heme-mediated oxidation, which does not occur in IRP1.	Iron	194-198	iron responsive element binding protein 2	Homo sapiens	79-83
31220756-2	2019	Heme regulatory motifs (HRMs) are conserved in the two IRP homologues IRP1 and IRP2 that specifically bind to two and three heme equivalents, respectively; however, only the heme binding to the iron-dependent degradation (IDD) domain of IRP2 causes heme-mediated oxidation, which does not occur in IRP1.	Iron	194-198	iron responsive element binding protein 2	Homo sapiens	237-241
31226389-6	2019	RESULTS: We identified 3 independent genetic variants (rs1800562 [C282Y] and rs1799945 [H63D] in HFE and rs855791 [V736A] in TMPRSS6) associated with liver iron content that reached the GWAS significance threshold (p <5 x 10-8).	Iron	156-160	transmembrane serine protease 6	Homo sapiens	125-132
31078097-1	2019	HYPOTHESIS: Modification of MIL-100(Fe) with ethanediamine (ED) is expected to improve the removal percentage of Pb(II) ions from aqueous solution.	Iron	36-38	submaxillary gland androgen regulated protein 3B	Homo sapiens	113-119
31078097-3	2019	Hence, it is necessary to study the influence of FA on the physicochemical property, adsorption behavior and mechanisms of ED-MIL-100(Fe) towards the removal of Pb(II) from water.	Iron	134-136	submaxillary gland androgen regulated protein 3B	Homo sapiens	161-167
31078097-4	2019	EXPERIMENTS: Batch adsorption experiments were conducted to compare adsorption capacity of MIL-100(Fe) and ED-MIL-100(Fe) for Pb(II).	Iron	118-120	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
31078097-6	2019	FINDINGS: ED-MIL-100(Fe) enabled 99% removal of Pb(II) from water at or below 60 mg L-1, whereas the MIL-100(Fe) hardly adsorbed any Pb(II).	Iron	21-23	submaxillary gland androgen regulated protein 3B	Homo sapiens	48-54
31162576-3	2019	OBJECTIVE: The aim of this study was to investigate whether early-life ID and the treatment iron dose alter brain regional GLUT expression in adult rats and mice.	Iron	92-96	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	123-127
31162576-11	2019	In Study 2, hippocampal Glut1 (+14%) and Hif1alpha (+147%) expression was upregulated in the iron-deficient DNTfR1-/- mice, but not in the iron-replete DNTfR1-/- mice, relative to the WT mice (P &lt; 0.05, all).	Iron	93-97	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	24-29
31368136-2	2019	Perinatal iron deficient male offspring exhibit enhanced conversion of big endothelin-1 to active endothelin-1, coinciding with decreased nitric oxide levels.	Iron	10-14	endothelin 1	Rattus norvegicus	98-110
31368136-12	2019	Male perinatal iron deficient offspring exhibit enhanced big endothelin-1 conversion to active endothelin-1 (P = 0.02) concomitant with decreased nitric oxide levels (P = 0.005).	Iron	15-19	endothelin 1	Rattus norvegicus	61-73
31368136-12	2019	Male perinatal iron deficient offspring exhibit enhanced big endothelin-1 conversion to active endothelin-1 (P = 0.02) concomitant with decreased nitric oxide levels (P = 0.005).	Iron	15-19	endothelin 1	Rattus norvegicus	95-107
30758712-1	2019	Transferrin (Tf) is a glycoprotein playing a critical role in iron homeostasis and transport and distribution throughout the body and within tissues and cells.	Iron	62-66	transferrin	Homo sapiens	0-11
30758712-1	2019	Transferrin (Tf) is a glycoprotein playing a critical role in iron homeostasis and transport and distribution throughout the body and within tissues and cells.	Iron	62-66	transferrin	Homo sapiens	13-15
32313871-4	2019	A defect in the Fe-S cluster formation by the fat-specific deletion of Bola3 significantly reduces mitochondrial lipoylation and fuel oxidation in BAT, leading to glucose intolerance and obesity.	Iron	16-20	bolA-like 3 (E. coli)	Mus musculus	71-76
31406370-0	2019	A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly.	Iron	41-45	poly(rC) binding protein 1	Homo sapiens	2-7
31406370-3	2019	Here we show that, in cells and in vitro, PCBP1 coordinates iron via conserved cysteine and glutamate residues and a molecule of noncovalently bound glutathione (GSH).	Iron	60-64	poly(rC) binding protein 1	Homo sapiens	42-47
31406370-5	2019	The Fe-GSH-bound form of PCBP1 complexes with cytosolic BolA2 via a bridging Fe ligand.	Iron	4-6	poly(rC) binding protein 1	Homo sapiens	25-30
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	223-227	poly(rC) binding protein 1	Homo sapiens	79-84
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	85-87	poly(rC) binding protein 1	Homo sapiens	24-29
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	85-87	poly(rC) binding protein 1	Homo sapiens	79-84
31377220-3	2019	Low levels of Zn as well as high levels of Cu, Mn, and Fe participate in the activation of signaling pathways of the inflammatory, oxidative and nitrosative stress (IO&NS) response, including nuclear factor kappa B and activator protein-1.	Iron	55-57	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	219-238
31531004-4	2019	The iron uptake of Fth1-BMSCs was measured with Prussian blue staining.	Iron	4-8	ferritin heavy chain 1	Rattus norvegicus	19-23
31894046-7	2019	It can be concluded that Galacto Oligosaccharides helped enhance the absorption of iron in anemic rats, reflected by increase in serum iron and serum ferritin levels and decrease in serum transferrin and total iron binding capacity.	Iron	83-87	transferrin	Rattus norvegicus	188-199
31041591-10	2019	Iron status improved in both groups (ferritin to c-reactive protein ratios).	Iron	0-4	C-reactive protein	Homo sapiens	49-67
31185326-5	2019	RESULTS: Modeling and a virtual screening analysis of FDX indicated that it is a stable protein with an iron-sulfur center that can discharge electrons produced from photo-excited Chl-a and transfers them to FDX-NADP+ reductase for NADP+ reduction in photosystem I, which is essential in the Calvin cycle for carbon assimilation.	Iron	104-108	petF	Undaria pinnatifida	54-57
31185326-5	2019	RESULTS: Modeling and a virtual screening analysis of FDX indicated that it is a stable protein with an iron-sulfur center that can discharge electrons produced from photo-excited Chl-a and transfers them to FDX-NADP+ reductase for NADP+ reduction in photosystem I, which is essential in the Calvin cycle for carbon assimilation.	Iron	104-108	petF	Undaria pinnatifida	208-211
31034704-0	2019	Under phosphate starvation conditions, Fe and Al trigger accumulation of the transcription factor STOP1 in the nucleus of Arabidopsis root cells.	Iron	39-41	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	98-103
31034704-2	2019	This growth arrest requires accumulation of the transcription factor STOP1 in the nucleus, where it activates the transcription of the malate transporter gene ALMT1; exuded malate is suspected to interact with extracellular Fe to inhibit root growth.	Iron	224-226	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	69-74
31034704-2	2019	This growth arrest requires accumulation of the transcription factor STOP1 in the nucleus, where it activates the transcription of the malate transporter gene ALMT1; exuded malate is suspected to interact with extracellular Fe to inhibit root growth.	Iron	224-226	aluminum-activated malate transporter 1	Arabidopsis thaliana	159-164
31034704-4	2019	Until now it was unclear whether Pi deficiency itself or Fe activates the accumulation of STOP1 in the nucleus.	Iron	57-59	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	90-95
31034704-5	2019	Here, by using different growth media to dissociate the effects of Fe from Pi deficiency itself, we demonstrate that Fe is sufficient to trigger the accumulation of STOP1 in the nucleus, which, in turn, activates the expression of ALMT1.	Iron	67-69	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	165-170
31034704-5	2019	Here, by using different growth media to dissociate the effects of Fe from Pi deficiency itself, we demonstrate that Fe is sufficient to trigger the accumulation of STOP1 in the nucleus, which, in turn, activates the expression of ALMT1.	Iron	117-119	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	165-170
31034704-5	2019	Here, by using different growth media to dissociate the effects of Fe from Pi deficiency itself, we demonstrate that Fe is sufficient to trigger the accumulation of STOP1 in the nucleus, which, in turn, activates the expression of ALMT1.	Iron	117-119	aluminum-activated malate transporter 1	Arabidopsis thaliana	231-236
31034704-6	2019	We also show that a low pH is necessary to stimulate the Fe-dependent accumulation of nuclear STOP1.	Iron	57-59	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	94-99
31034704-7	2019	Furthermore, pharmacological experiments indicate that Fe inhibits proteasomal degradation of STOP1.	Iron	55-57	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	94-99
31034704-8	2019	We also show that Al acts like Fe for nuclear accumulation of STOP1 and ALMT1 expression, and that the overaccumulation of STOP1 in the nucleus of the als3 mutant grown in low-Pi conditions could be abolished by Fe deficiency.	Iron	31-33	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	62-67
31470879-1	2019	BACKGROUND: Reduction of the body iron stores can improve hyperandrogenemia and insulin resistance.	Iron	34-38	insulin	Homo sapiens	80-87
31397998-7	2019	Subsequently, the iron ions released from the ionization of Fe3O4 in the acidic environment selectively convert H2O2 into highly toxic  OH by Fenton reaction, dramatically improving CDT with minimal systemic toxicity due to low NQO1 expression in normal tissues.	Iron	18-22	NAD(P)H quinone dehydrogenase 1	Homo sapiens	228-232
31467270-0	2019	GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity.	Iron	34-38	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	0-5
31467270-0	2019	GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity.	Iron	63-67	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	0-5
31467270-3	2019	Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitative locus for root tolerance to Fe-toxicity in Arabidopsis using genome-wide association studies and allelic complementation.	Iron	126-128	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	50-55
31467270-6	2019	GSNOR maintains root meristem activity and prevents cell death via inhibiting Fe-dependent nitrosative and oxidative cytotoxicity.	Iron	78-80	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	0-5
31467270-7	2019	GSNOR is also required for root tolerance to Fe-toxicity throughout higher plants such as legumes and monocots, which exposes an opportunity to address crop production under high-Fe conditions using natural GSNOR variants.	Iron	45-47	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	0-5
31467270-7	2019	GSNOR is also required for root tolerance to Fe-toxicity throughout higher plants such as legumes and monocots, which exposes an opportunity to address crop production under high-Fe conditions using natural GSNOR variants.	Iron	45-47	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	207-212
31467270-7	2019	GSNOR is also required for root tolerance to Fe-toxicity throughout higher plants such as legumes and monocots, which exposes an opportunity to address crop production under high-Fe conditions using natural GSNOR variants.	Iron	179-181	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	0-5
31467270-7	2019	GSNOR is also required for root tolerance to Fe-toxicity throughout higher plants such as legumes and monocots, which exposes an opportunity to address crop production under high-Fe conditions using natural GSNOR variants.	Iron	179-181	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	207-212
31416268-3	2019	This is underpinned by the widespread expression of transferrin receptors in the developing brain, which, in later life, is restricted to cells of the blood-brain and blood-cerebrospinal fluid barriers and neuronal cells, hence ensuring a sustained iron supply to the brain, even in the fully developed brain.	Iron	249-253	transferrin	Homo sapiens	52-63
31140779-10	2019	These key features make 4 a potential MFM platform to develop therapeutic agents for metal (Cu, Zn and Fe)-dependent and -independent multifaceted Abeta toxicity of AD.	Iron	103-105	amyloid beta precursor protein	Homo sapiens	147-152
31497011-14	2019	MPO levels rose significantly during the dialysis session with IV iron, but not in the session without iron.	Iron	66-70	myeloperoxidase	Homo sapiens	0-3
31497011-15	2019	Moreover, the relative increase in MPO and sC5b-9 by IV iron correlated significantly.	Iron	56-60	myeloperoxidase	Homo sapiens	35-38
31128393-2	2019	This study deals with the removal of NO3- and HCO3- from contaminated wastewater using Fe-exchanged nano-bentonite and Fe3O4 nanoparticles.	Iron	87-89	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
31128393-6	2019	According to the Sips isothermal model, the Fe-exchanged nano-bentonite exhibited the highest NO3- and HCO3- adsorption potential of 64.76 mg g-1 and 9.73 meq g-1, respectively, while the respective values for Fe3O4 nanoparticles were 49.90 mg g-1 and 3.07 meq g-1.	Iron	44-46	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
31128393-7	2019	Thus, inexpensiveness and easy preparation process of Fe-exchanged nano-bentonite make it attractive for NO3- and HCO3- removal from contaminated wastewater with significant environmental and economic benefits.	Iron	54-56	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
31262762-3	2019	The study with multiple carbapenem-resistant strains revealed that the %fT &gt;MIC determined in iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) better reflected the in vivo efficacy of cefiderocol than the %fT &gt;MIC determined in cation-adjusted Mueller-Hinton broth (CAMHB).	Iron	97-101	microphthalmia Japan	Mus musculus	79-82
31262762-3	2019	The study with multiple carbapenem-resistant strains revealed that the %fT &gt;MIC determined in iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) better reflected the in vivo efficacy of cefiderocol than the %fT &gt;MIC determined in cation-adjusted Mueller-Hinton broth (CAMHB).	Iron	97-101	microphthalmia Japan	Mus musculus	229-232
31489256-3	2019	Dystonic opisthotonus has been described as a characteristic feature of neurodegeneration with brain iron accumulation (NBIA) related to PANK2 and PLA2G6 mutations.	Iron	101-105	pantothenate kinase 2	Homo sapiens	137-142
31489256-3	2019	Dystonic opisthotonus has been described as a characteristic feature of neurodegeneration with brain iron accumulation (NBIA) related to PANK2 and PLA2G6 mutations.	Iron	101-105	phospholipase A2 group VI	Homo sapiens	147-153
31423010-8	2019	Nrf2-mediated FPN1 downregulation promoted intracellular iron accumulation and reactive oxygen species.	Iron	57-61	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31347363-0	2019	Iron-Catalyzed Regioselective Remote C(sp2)-H Carboxylation of Naphthyl and Quinoline Amides.	Iron	0-4	Sp2 transcription factor	Homo sapiens	37-42
31416268-10	2019	Cerebral iron deficiency is expected to be curable with iron substitution therapy, as the brain, privileged by the cerebral vascular transferrin receptor expression, is expected to facilitate iron extraction from the circulation and enable transport further into the brain.	Iron	9-13	transferrin	Homo sapiens	133-144
31416268-10	2019	Cerebral iron deficiency is expected to be curable with iron substitution therapy, as the brain, privileged by the cerebral vascular transferrin receptor expression, is expected to facilitate iron extraction from the circulation and enable transport further into the brain.	Iron	56-60	transferrin	Homo sapiens	133-144
31395877-2	2019	Fe-S clusters are biosynthesized on the scaffold protein ISCU, with cysteine desulfurase NFS1 providing sulfur as persulfide and ferredoxin FDX2 supplying electrons, in a process stimulated by FXN but not clearly understood.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	57-61
31353385-4	2019	Here, we report a novel synthetic approach to fabricate a Ni-S/MIL-53(Fe) electrode by electrodepositing sulfur-engineered amorphous nickel hydroxides on MIL-53(Fe) nanosheets.	Iron	70-72	solute carrier family 5 member 5	Homo sapiens	58-62
31353385-4	2019	Here, we report a novel synthetic approach to fabricate a Ni-S/MIL-53(Fe) electrode by electrodepositing sulfur-engineered amorphous nickel hydroxides on MIL-53(Fe) nanosheets.	Iron	161-163	solute carrier family 5 member 5	Homo sapiens	58-62
31353385-5	2019	The obtained binder-free, self-supported Ni-S/MIL-53(Fe) shows high OER activity with overpotentials of 256 and 298 mV to achieve 10 and 100 mA cm-2, respectively.	Iron	53-55	solute carrier family 5 member 5	Homo sapiens	41-45
31395877-3	2019	Here, we report the breakdown of this process, made possible by removing a zinc ion in ISCU that hinders iron insertion and promotes non-physiological Fe-S cluster synthesis from free sulfide in vitro.	Iron	105-109	iron-sulfur cluster assembly enzyme	Homo sapiens	87-91
31395877-4	2019	By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters.	Iron	195-197	iron-sulfur cluster assembly enzyme	Homo sapiens	21-25
31395877-3	2019	Here, we report the breakdown of this process, made possible by removing a zinc ion in ISCU that hinders iron insertion and promotes non-physiological Fe-S cluster synthesis from free sulfide in vitro.	Iron	151-153	iron-sulfur cluster assembly enzyme	Homo sapiens	87-91
31395877-4	2019	By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters.	Iron	27-31	iron-sulfur cluster assembly enzyme	Homo sapiens	21-25
31332310-8	2019	SS120 has a different tactic to cope with low-light levels, and SS120 thylakoids contained hundreds of closely packed Pcb-PSI supercomplexes that economize on the extra iron and nitrogen required to assemble PSI-only domains.	Iron	169-173	pyruvate carboxylase	Homo sapiens	118-121
31389965-0	2019	Bifunctional MIL-53(Fe) with pyrophosphate-mediated peroxidase-like activity and oxidation-stimulated fluorescence switching for alkaline phosphatase detection.	Iron	20-22	alkaline phosphatase, placental	Homo sapiens	129-149
30853478-8	2019	Moreover, serum levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) were markedly decreased in patients with iron repletion compared with placebo treatment (WMD: -332.48 pg/mL; 95% CI, -497.48 to -167.47; WMD: -4.64 mg/L; 95% CI, -6.12 to -3.17, respectively).	Iron	150-154	C-reactive protein	Homo sapiens	84-102
30853478-8	2019	Moreover, serum levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) were markedly decreased in patients with iron repletion compared with placebo treatment (WMD: -332.48 pg/mL; 95% CI, -497.48 to -167.47; WMD: -4.64 mg/L; 95% CI, -6.12 to -3.17, respectively).	Iron	150-154	C-reactive protein	Homo sapiens	104-107
30853478-9	2019	CONCLUSIONS: Our meta-analysis suggests that iron therapy can reduce heart failure hospitalization, increase cardiac function, improve quality of life, and decrease serum levels of NT-proBNP and CRP in patients with heart failure.	Iron	45-49	C-reactive protein	Homo sapiens	195-198
31339120-8	2019	In addition, compared with FeSO4, APFP-Fe promoted significant weight gain and effectively improved haemoglobin, serum iron and transferrin levels, and recovery of the capacity of iron binding with transferrin, especially at the medium and high doses.	Iron	180-184	transferrin	Rattus norvegicus	198-209
31447555-5	2019	NAC can effectively mitigate iron-induced oxidative injury of cardiomyocytes, evidenced by reduced production of MDA, 8-iso-PGF2alpha, and 8-OHDG and maintained concentrations of SOD, CAT, GSH-Px, and GSH in ELISA and biochemical tests; downregulated expression of CHOP, GRP78, p62, and LC3-II proteins in Western Blot, and less cardiomyocytes apoptosis in flow cytometric analysis.	Iron	29-33	catalase	Rattus norvegicus	184-187
30968973-14	2019	Taken together, our results show that hypobaric hypoxia can stimulate erythropoiesis, which systemically draws iron away from nonhematopoietic tissue through decreased hepcidin levels.	Iron	111-115	hepcidin antimicrobial peptide	Rattus norvegicus	168-176
31291107-4	2019	PtmU3 adopts an unprecedented triosephosphate isomerase (TIM) barrel structural fold for this class of enzymes and possesses a noncanonical diiron active site architecture with a saturated six-coordinate iron center lacking a mu-oxo bridge.	Iron	142-146	triosephosphate isomerase 1	Homo sapiens	57-60
31216493-2	2019	In this study, an iron-based coordination polymer (Fe-CNP) loaded with doxorubicin (DOX) was assessed as a dual-function agent for photothermal therapy (PTT) and tumor-targeted chemotherapy.	Iron	18-22	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	54-57
30776900-0	2019	Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.	Iron	0-4	beta-secretase 1	Homo sapiens	46-51
30776900-4	2019	Further results revealed that extracellular iron accumulation might potentially induce binding of APP to BACE1 for amyloid formation and decrease the capability of APP/Fpn1 in mediating iron export.	Iron	44-48	beta-secretase 1	Homo sapiens	105-110
30927265-5	2019	As exhibited, we observed that CD68 was significant enriched by high iron diet in apoE-deficient mice.	Iron	69-73	apolipoprotein E	Mus musculus	82-86
30927265-6	2019	In addition, transforming growth factor beta, tumor necrosis factor alpha, interleukin 6 (IL-6), IL-23, IL-10, and IL-1beta levels were also greatly induced by high iron diet.	Iron	165-169	tumor necrosis factor	Mus musculus	46-73
30927265-6	2019	In addition, transforming growth factor beta, tumor necrosis factor alpha, interleukin 6 (IL-6), IL-23, IL-10, and IL-1beta levels were also greatly induced by high iron diet.	Iron	165-169	interleukin 6	Mus musculus	75-88
30927265-6	2019	In addition, transforming growth factor beta, tumor necrosis factor alpha, interleukin 6 (IL-6), IL-23, IL-10, and IL-1beta levels were also greatly induced by high iron diet.	Iron	165-169	interleukin 6	Mus musculus	90-94
30927265-6	2019	In addition, transforming growth factor beta, tumor necrosis factor alpha, interleukin 6 (IL-6), IL-23, IL-10, and IL-1beta levels were also greatly induced by high iron diet.	Iron	165-169	interleukin 10	Mus musculus	104-109
30927265-6	2019	In addition, transforming growth factor beta, tumor necrosis factor alpha, interleukin 6 (IL-6), IL-23, IL-10, and IL-1beta levels were also greatly induced by high iron diet.	Iron	165-169	interleukin 1 beta	Mus musculus	115-123
31088771-1	2019	Pantothenate kinase-associated neurodegeneration (PKAN) is linked to brain iron accumulation caused by PANK2 gene mutation.	Iron	75-79	pantothenate kinase 2	Homo sapiens	0-48
31088771-1	2019	Pantothenate kinase-associated neurodegeneration (PKAN) is linked to brain iron accumulation caused by PANK2 gene mutation.	Iron	75-79	pantothenate kinase 2	Homo sapiens	50-54
31088771-1	2019	Pantothenate kinase-associated neurodegeneration (PKAN) is linked to brain iron accumulation caused by PANK2 gene mutation.	Iron	75-79	pantothenate kinase 2	Homo sapiens	103-108
31300544-11	2019	Overall, these data demonstrate that iron mediates morphine-induced FHC upregulation and consequent dendritic spine deficits and implicate endolysosomal iron efflux to the cytoplasm in these effects.	Iron	37-41	ferritin heavy chain 1	Rattus norvegicus	68-71
31002437-2	2019	Local administration of dermal ABCB5+ -derived mesenchymal stem cells (MSCs) attenuated macrophage-dominated inflammation and thereby accelerated healing of full-thickness excisional wounds in the iron-overload mouse model mimicking the nonhealing state of human venous leg ulcers.	Iron	197-201	ATP-binding cassette, sub-family B (MDR/TAP), member 5	Mus musculus	31-36
31300544-0	2019	Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons.	Iron	45-49	ferritin heavy chain 1	Rattus norvegicus	75-95
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	Iron	28-32	transforming growth factor beta 1	Homo sapiens	117-126
31300544-10	2019	In line with this, chelation of endolysosomal iron (but not extracellular iron) blocked morphine-induced FHC upregulation and dendritic spine reduction, whereas iron overloading mimicked the effect of morphine on FHC and dendritic spines.	Iron	46-50	ferritin heavy chain 1	Rattus norvegicus	105-108
31300544-10	2019	In line with this, chelation of endolysosomal iron (but not extracellular iron) blocked morphine-induced FHC upregulation and dendritic spine reduction, whereas iron overloading mimicked the effect of morphine on FHC and dendritic spines.	Iron	46-50	ferritin heavy chain 1	Rattus norvegicus	213-216
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	Iron	28-32	interleukin 6	Homo sapiens	131-135
31153641-0	2019	Increased hepcidin in hemorrhagic plaques correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages.	Iron	58-62	interleukin 6	Homo sapiens	74-78
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	Iron	342-346	transforming growth factor beta 1	Homo sapiens	61-70
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	Iron	342-346	interleukin 6	Homo sapiens	75-79
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	Iron	80-84	transforming growth factor beta 1	Homo sapiens	151-160
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	Iron	80-84	interleukin 6	Homo sapiens	165-169
31229404-2	2019	Here, we describe a mechanism of FBXL5 regulation involving its interaction with the cytosolic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, FAM96B, and CIAO1.	Iron	95-99	nuclear receptor coactivator 5	Homo sapiens	118-121
31497476-2	2019	LYRM4 gene codifies for ISD11, a small protein (11 kDa) acting as an iron-sulfur cluster, that has been recently confirmed as a disease-causing gene for mitochondrial disorders.	Iron	69-73	LYR motif containing 4	Homo sapiens	0-5
31497476-2	2019	LYRM4 gene codifies for ISD11, a small protein (11 kDa) acting as an iron-sulfur cluster, that has been recently confirmed as a disease-causing gene for mitochondrial disorders.	Iron	69-73	LYR motif containing 4	Homo sapiens	24-29
31366108-4	2019	For example, cancer cells frequently upregulate transferrin (increasing uptake of iron) and down regulate ferroportin (decreasing efflux of intracellular iron).	Iron	82-86	transferrin	Homo sapiens	48-59
31358831-1	2019	Systemic iron homeostasis dysregulation is primarily associated with inflammation- associated anemia (AI) due to hepcidin up-regulation.	Iron	9-13	hepcidin antimicrobial peptide	Rattus norvegicus	113-121
31229404-0	2019	An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.	Iron	86-90	F-box and leucine rich repeat protein 5	Homo sapiens	40-45
31229404-0	2019	An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.	Iron	86-90	nuclear receptor coactivator 5	Homo sapiens	54-57
31229404-1	2019	The iron-sensing protein FBXL5 is the substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradation of iron regulatory proteins (IRPs).	Iron	4-8	F-box and leucine rich repeat protein 5	Homo sapiens	25-30
31229404-2	2019	Here, we describe a mechanism of FBXL5 regulation involving its interaction with the cytosolic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, FAM96B, and CIAO1.	Iron	95-99	F-box and leucine rich repeat protein 5	Homo sapiens	33-38
31153641-0	2019	Increased hepcidin in hemorrhagic plaques correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages.	Iron	58-62	signal transducer and activator of transcription 3	Homo sapiens	79-84
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	37-41	heme oxygenase 1	Mus musculus	75-80
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	37-41	CD163 antigen	Mus musculus	95-100
31153641-11	2019	In conclusion, our data indicate that hepcidin levels are increased in hemorrhagic plaques, which correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages.	Iron	114-118	interleukin 6	Homo sapiens	130-134
31153641-11	2019	In conclusion, our data indicate that hepcidin levels are increased in hemorrhagic plaques, which correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages.	Iron	114-118	signal transducer and activator of transcription 3	Homo sapiens	135-140
31187614-2	2019	Here, we report a metallic Fe (iron)-Au (gold) BNW-based platform for capturing CD8 T cells and the interferon-gamma (gamma) they secrete, both of which play key roles in controlling infectious diseases such as tuberculosis, at the single-cell level.	Iron	27-29	interferon gamma	Homo sapiens	100-116
31233037-3	2019	Obese rats fed an iron/fat-enriched diet showed decreased levels of testicular total Testosterone (T) and iron exporter ferroportin but increased levels of testicular iron and hepcidin, and these effects were more evident with a >1 g ferric iron per kg diet.	Iron	18-22	hepcidin antimicrobial peptide	Rattus norvegicus	176-184
31233037-4	2019	A western blot analysis showed that an iron/fat-enriched diet triggered testicular endoplasmic reticular (ER) stress but decreased mitochondrion biogenesis proteins (PGC1alpha and TFAM) and T-converting proteins (StAR, CYP11A, and 17beta-HSD).	Iron	39-43	PPARG coactivator 1 alpha	Rattus norvegicus	166-175
31233037-4	2019	A western blot analysis showed that an iron/fat-enriched diet triggered testicular endoplasmic reticular (ER) stress but decreased mitochondrion biogenesis proteins (PGC1alpha and TFAM) and T-converting proteins (StAR, CYP11A, and 17beta-HSD).	Iron	39-43	steroidogenic acute regulatory protein	Rattus norvegicus	213-217
31233037-4	2019	A western blot analysis showed that an iron/fat-enriched diet triggered testicular endoplasmic reticular (ER) stress but decreased mitochondrion biogenesis proteins (PGC1alpha and TFAM) and T-converting proteins (StAR, CYP11A, and 17beta-HSD).	Iron	39-43	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	231-241
31233037-7	2019	Future study targeting the testicular hepcidin-ferroportin axis may offer a therapeutic tool to alleviate testicular iron retention and mitochondrial-ER stress in Leydig"s cells.	Iron	117-121	hepcidin antimicrobial peptide	Rattus norvegicus	38-46
30998950-5	2019	In mice serum, the levels of cytokines including TNF-alpha, IFN-gamma and IL-10 restored and the contents of hemolysin were also found elevated after treatment with polysaccharide and its iron complex.	Iron	188-192	tumor necrosis factor	Mus musculus	49-58
30998950-5	2019	In mice serum, the levels of cytokines including TNF-alpha, IFN-gamma and IL-10 restored and the contents of hemolysin were also found elevated after treatment with polysaccharide and its iron complex.	Iron	188-192	interferon gamma	Mus musculus	60-69
30998950-5	2019	In mice serum, the levels of cytokines including TNF-alpha, IFN-gamma and IL-10 restored and the contents of hemolysin were also found elevated after treatment with polysaccharide and its iron complex.	Iron	188-192	interleukin 10	Mus musculus	74-79
31300018-1	2019	BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive neurodegenerative disorder with brain iron accumulation (NBIA).	Iron	132-136	pantothenate kinase 2	Homo sapiens	62-66
31168542-2	2019	Grx2 catalyzes protein glutathionylation/de-glutathionylation and can coordinate an iron-sulfur cluster, forming inactive dimers stabilized by two molecules of glutathione.	Iron	84-88	glutaredoxin 2	Homo sapiens	0-4
31168542-7	2019	In addition, Grx2 monomerization led to an increase free iron ions concentration in the mitochondrial matrix, induction of lipid peroxidation and decrease of the mitochondrial membrane potential, indicating that the disassembly of Grx2 dimer involved the release of the iron-sulfur cluster in the mitochondrial matrix.	Iron	57-61	glutaredoxin 2	Homo sapiens	13-17
31168542-7	2019	In addition, Grx2 monomerization led to an increase free iron ions concentration in the mitochondrial matrix, induction of lipid peroxidation and decrease of the mitochondrial membrane potential, indicating that the disassembly of Grx2 dimer involved the release of the iron-sulfur cluster in the mitochondrial matrix.	Iron	270-274	glutaredoxin 2	Homo sapiens	13-17
31168542-7	2019	In addition, Grx2 monomerization led to an increase free iron ions concentration in the mitochondrial matrix, induction of lipid peroxidation and decrease of the mitochondrial membrane potential, indicating that the disassembly of Grx2 dimer involved the release of the iron-sulfur cluster in the mitochondrial matrix.	Iron	270-274	glutaredoxin 2	Homo sapiens	231-235
31168542-9	2019	Thus, by sensing the overall cellular redox conditions, mitochondrial Grx2 dimers become active monomers upon oxidative stress induced by sodium selenite with the consequent release of the iron-sulfur cluster, leading to activation of the intrinsic apoptotic pathway.	Iron	189-193	glutaredoxin 2	Homo sapiens	70-74
31187614-2	2019	Here, we report a metallic Fe (iron)-Au (gold) BNW-based platform for capturing CD8 T cells and the interferon-gamma (gamma) they secrete, both of which play key roles in controlling infectious diseases such as tuberculosis, at the single-cell level.	Iron	31-36	interferon gamma	Homo sapiens	100-116
31477256-1	2019	Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production and coordinates erythropoiesis with iron metabolism.	Iron	215-219	erythropoietin	Homo sapiens	153-167
31075224-6	2019	Globally, mRNA for the serum iron binding protein transferrin (TF), which has been associated with age-related macular degeneration pathogenesis, was enriched in peripheral samples.	Iron	29-33	transferrin	Homo sapiens	50-61
30978615-10	2019	There were positive correlation between urine iron level and transferrin saturation (r = 0.559, p = 0.01) and serum ferritin (r = 0.291, p = 0.03), no correlation found with T2* MRI results.	Iron	46-50	transferrin	Homo sapiens	61-72
31075224-6	2019	Globally, mRNA for the serum iron binding protein transferrin (TF), which has been associated with age-related macular degeneration pathogenesis, was enriched in peripheral samples.	Iron	29-33	transferrin	Homo sapiens	63-65
30387158-8	2019	Icariin could protect against iron overload-induced mitochondrial membrane potential dysfunction and ROS production, promote osteoblast survival and reverse the reduction of Runx2, alkaline phosphatase, and osteopontin expression induced by iron overload.	Iron	241-245	RUNX family transcription factor 2	Homo sapiens	174-179
31423058-0	2019	Evaluation of Iron Status in Patients of Chronic Kidney Disease - A Study to Assess the Best Indicators Including Serum Transferrin Receptor Assay.	Iron	14-18	transferrin	Homo sapiens	120-131
31176681-3	2019	The RED protocols do not require any albumin or animal components and require ten- to twentyfold less transferrin (Tf) than previously, because iron is provided to the differentiating erythroblasts by small amounts of recombinant Tf supplemented with FeIII-EDTA, an iron chelator that allows Tf recycling to take place in cell culture.	Iron	144-148	transferrin	Homo sapiens	115-117
31176681-3	2019	The RED protocols do not require any albumin or animal components and require ten- to twentyfold less transferrin (Tf) than previously, because iron is provided to the differentiating erythroblasts by small amounts of recombinant Tf supplemented with FeIII-EDTA, an iron chelator that allows Tf recycling to take place in cell culture.	Iron	144-148	transferrin	Homo sapiens	230-232
31176681-3	2019	The RED protocols do not require any albumin or animal components and require ten- to twentyfold less transferrin (Tf) than previously, because iron is provided to the differentiating erythroblasts by small amounts of recombinant Tf supplemented with FeIII-EDTA, an iron chelator that allows Tf recycling to take place in cell culture.	Iron	144-148	transferrin	Homo sapiens	230-232
31198069-0	2019	Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in beta-thalassemia/HbE patients.	Iron	125-129	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
31092540-6	2019	To investigate the mechanisms by which Paf1 regulates protein-coding genes, we focused on genes involved in iron and phosphate homeostasis, which were differentially affected by PAF1 deletion.	Iron	108-112	Paf1p	Saccharomyces cerevisiae S288C	39-43
31092540-6	2019	To investigate the mechanisms by which Paf1 regulates protein-coding genes, we focused on genes involved in iron and phosphate homeostasis, which were differentially affected by PAF1 deletion.	Iron	108-112	Paf1p	Saccharomyces cerevisiae S288C	178-182
31092540-8	2019	In contrast, the inhibition of iron gene expression by Paf1 correlates with a defect in H3 K36 trimethylation.	Iron	31-35	Paf1p	Saccharomyces cerevisiae S288C	55-59
31092540-9	2019	Finally, we showed that one iron regulon gene, FET4, is coordinately controlled by Paf1 and transcription of upstream noncoding DNA.	Iron	28-32	Fet4p	Saccharomyces cerevisiae S288C	47-51
31092540-9	2019	Finally, we showed that one iron regulon gene, FET4, is coordinately controlled by Paf1 and transcription of upstream noncoding DNA.	Iron	28-32	Paf1p	Saccharomyces cerevisiae S288C	83-87
30948790-3	2019	NDUFS6 encodes a 13 kiloDaltons subunit, which is part of the peripheral arm of complex I and is localized in the iron-sulfur fraction.	Iron	114-118	NADH:ubiquinone oxidoreductase subunit S6	Homo sapiens	0-6
31273533-6	2019	The new method was applied in the determination of iron in the spiked tap water samples and the sandy-soil reference material.	Iron	51-55	SEC14 like lipid binding 2	Homo sapiens	70-73
31123076-4	2019	Proteomic analysis identified an association between transferrin presence and infection risk, as peritoneal transferrin was discovered to be iron-saturated, which was in marked contrast to transferrin in blood.	Iron	141-145	transferrin	Homo sapiens	53-64
30130276-0	2019	Iron Refractory Iron Deficiency Anemia Due to 374 Base Pairs Deletion in the TMPRSS6 Gene.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	77-84
30130276-0	2019	Iron Refractory Iron Deficiency Anemia Due to 374 Base Pairs Deletion in the TMPRSS6 Gene.	Iron	16-20	transmembrane serine protease 6	Homo sapiens	77-84
31202468-1	2019	BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare genetic disorder characterised by progressive generalised dystonia and brain iron accumulation.	Iron	155-159	pantothenate kinase 2	Homo sapiens	62-66
30980085-6	2019	Additionally, both male and female demographic expansions were observed during the early Mesolithic (~10 ka), with two later major male-specific expansions during the Neolithic period (~4-5 ka) and the Bronze/Iron Age (~2.0-2.5 ka).	Iron	209-213	renin binding protein	Homo sapiens	214-217
30804242-6	2019	Recently, we have described that dermal fibroblasts obtained from PKAN patients can manifest the main pathological changes of the disease such as intracellular iron accumulation accompanied by large amounts of lipofuscin granules, mitochondrial dysfunction and a pronounced increase of markers of oxidative stress.	Iron	160-164	pantothenate kinase 2	Homo sapiens	66-70
31123076-4	2019	Proteomic analysis identified an association between transferrin presence and infection risk, as peritoneal transferrin was discovered to be iron-saturated, which was in marked contrast to transferrin in blood.	Iron	141-145	transferrin	Homo sapiens	108-119
31123076-4	2019	Proteomic analysis identified an association between transferrin presence and infection risk, as peritoneal transferrin was discovered to be iron-saturated, which was in marked contrast to transferrin in blood.	Iron	141-145	transferrin	Homo sapiens	108-119
31123076-5	2019	Further, use of radioactive iron-labeled transferrin showed peritoneal transferrin could act as a direct iron source for the growth of peritonitis-causing bacteria.	Iron	28-32	transferrin	Homo sapiens	41-52
31123076-5	2019	Further, use of radioactive iron-labeled transferrin showed peritoneal transferrin could act as a direct iron source for the growth of peritonitis-causing bacteria.	Iron	28-32	transferrin	Homo sapiens	71-82
31123076-5	2019	Further, use of radioactive iron-labeled transferrin showed peritoneal transferrin could act as a direct iron source for the growth of peritonitis-causing bacteria.	Iron	105-109	transferrin	Homo sapiens	41-52
31123076-5	2019	Further, use of radioactive iron-labeled transferrin showed peritoneal transferrin could act as a direct iron source for the growth of peritonitis-causing bacteria.	Iron	105-109	transferrin	Homo sapiens	71-82
31123076-6	2019	We also found catecholamine stress hormones noradrenaline and adrenaline were present in the dialysates and were apparently involved in enhancing the growth of the bacteria via transferrin iron provision.	Iron	189-193	transferrin	Homo sapiens	177-188
31123076-7	2019	This suggests the iron biology status of the PD patient may be a risk factor for development of infectious peritonitisConclusions:Collectively, our study suggests transferrin and catecholamines within peritoneal dialysate may be indicators of the potential for bacterial growth in HPD and, as infection risk factors, represent possible future targets for therapeutic manipulation.	Iron	18-22	transferrin	Homo sapiens	163-174
31054940-8	2019	Although we formerly reported that SESN2 expression was reduced after p53 mutation in colon tumors, mouse colon tumors, which have intact p53 and NRF2, induced SESN2 expression in response to iron stimulus.	Iron	192-196	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
31263155-7	2019	Interestingly, we found that the expression of the mRNA encoding ferroportin 1, a transmembrane protein that cooperates with CP and HEPH to export iron from cells, was positively correlated with Cp expression in astrocytes, and with Heph expression in oligodendrocytes.	Iron	147-151	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	65-78
31316498-9	2019	The functional relevance of iron overloading was demonstrated by a marked induction of the expression of interleukin-6 in iron-treated macrophages.	Iron	28-32	interleukin 6	Homo sapiens	105-118
31316498-0	2019	Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation.	Iron	0-4	arachidonate 5-lipoxygenase	Homo sapiens	30-44
31316498-2	2019	It is well known that 5-LOX activation in innate immunity cells is related to different iron-associated pro-inflammatory disorders, including cancer, neurodegenerative diseases, and atherosclerosis.	Iron	88-92	arachidonate 5-lipoxygenase	Homo sapiens	22-27
31316498-9	2019	The functional relevance of iron overloading was demonstrated by a marked induction of the expression of interleukin-6 in iron-treated macrophages.	Iron	122-126	interleukin 6	Homo sapiens	105-118
31316498-10	2019	Importantly, pre-treatment of cells with the iron-chelating agent deferoxamine completely abolished the hemin-dependent translocation of 5-LOX to the nuclear fraction, and significantly reverted its effect on interleukin-6 overexpression.	Iron	45-49	arachidonate 5-lipoxygenase	Homo sapiens	137-142
31316498-10	2019	Importantly, pre-treatment of cells with the iron-chelating agent deferoxamine completely abolished the hemin-dependent translocation of 5-LOX to the nuclear fraction, and significantly reverted its effect on interleukin-6 overexpression.	Iron	45-49	interleukin 6	Homo sapiens	209-222
31261772-0	2019	Changes in Iron Metabolism Induced by Anti-Interleukin-6 Receptor Monoclonal Antibody are Associated with an Increased Risk of Infection.	Iron	11-15	interleukin 6	Homo sapiens	43-56
31316498-11	2019	These results suggest that exogenous iron modulates the biological activity of 5-LOX in macrophages by increasing its ability to bind to nuclear membranes, further supporting a role for iron in inflammation-based diseases where its homeostasis is altered and suggesting further evidence of risks related to iron overload.	Iron	37-41	arachidonate 5-lipoxygenase	Homo sapiens	79-84
31261772-1	2019	(1) Background: Treatment of patients with rheumatoid arthritis (RA) with an anti-IL-6 receptor (anti-IL-6R) monoclonal antibody (tocilizumab) has been found to influence iron metabolism.	Iron	171-175	interleukin 6 receptor	Homo sapiens	102-107
31261772-2	2019	The objective of the present study was to ascertain whether changes in iron metabolism induced by anti-IL-6R biologic therapy were independently associated with an increased infection risk.	Iron	71-75	interleukin 6 receptor	Homo sapiens	103-108
31316498-11	2019	These results suggest that exogenous iron modulates the biological activity of 5-LOX in macrophages by increasing its ability to bind to nuclear membranes, further supporting a role for iron in inflammation-based diseases where its homeostasis is altered and suggesting further evidence of risks related to iron overload.	Iron	186-190	arachidonate 5-lipoxygenase	Homo sapiens	79-84
31261772-11	2019	(4) Conclusions: This study identified a probable association between infection risk and higher serum iron and transferrin saturation in patients with RA on anti-IL-6R biologic therapy.	Iron	102-106	transferrin	Homo sapiens	111-122
31316498-11	2019	These results suggest that exogenous iron modulates the biological activity of 5-LOX in macrophages by increasing its ability to bind to nuclear membranes, further supporting a role for iron in inflammation-based diseases where its homeostasis is altered and suggesting further evidence of risks related to iron overload.	Iron	186-190	arachidonate 5-lipoxygenase	Homo sapiens	79-84
31261772-11	2019	(4) Conclusions: This study identified a probable association between infection risk and higher serum iron and transferrin saturation in patients with RA on anti-IL-6R biologic therapy.	Iron	102-106	interleukin 6 receptor	Homo sapiens	162-167
31234806-5	2019	Iron status was defined using soluble transferrin receptor (sTfR) and body iron stores (BIS).	Iron	0-4	transferrin	Homo sapiens	38-49
31117657-9	2019	The implied proximities of C21 to the iron cofactor and C26 to Y68 support a new docking model of the enzyme-substrate complex that is consistent with all available data.	Iron	38-42	TBL1X/Y related 1	Homo sapiens	27-30
31125218-3	2019	In the present computational study, we examine the HER activity of early N2RR intermediates in EP3 (E = B, Si) ligated single-site biomimetic iron complexes by calculating and comparing the activation Gibbs free energies of HER and N2RR elementary steps.	Iron	142-146	prostaglandin E receptor 3	Homo sapiens	95-98
31234559-5	2019	It is proposed that Triapine acquires iron from transferrin in cells including tumor cells.	Iron	38-42	transferrin	Homo sapiens	48-59
31234559-6	2019	Here, it is shown that iron from purified Fe-transferrin is transferred to Triapine after the addition of ascorbate.	Iron	23-27	transferrin	Homo sapiens	45-56
31226805-9	2019	Prostacyclin synthase could potentially be involved in functional interactions with identified novel protein partners participating in iron and heme metabolism, oxidative stress, xenobiotic and drugs metabolism, glutathione and prostaglandin metabolism.	Iron	135-139	prostaglandin I2 synthase	Rattus norvegicus	0-21
31208055-3	2019	In this paper, we evaluated the mRNA levels of genes related to iron metabolism (PCBP1, PCBP2, FTL, FTH, and TFRC) in leukocytes of 24 amateur runners at four time points: before, immediately after, 3 h after, and 24 h after a marathon.	Iron	64-68	poly(rC) binding protein 1	Homo sapiens	81-86
30975898-1	2019	In humans, mitochondrial iron-sulfur cluster biosynthesis is an essential biochemical process mediated by the assembly complex consisting of cysteine desulfurase (NFS1), LYR protein (ISD11), acyl-carrier protein (ACP), and the iron-sulfur cluster assembly scaffold protein (ISCU2).	Iron	25-29	LYR motif containing 4	Homo sapiens	183-188
31040179-5	2019	The mitochondrial biosynthesis of (Fe-S)int required ISC components such as Nfs1 cysteine desulfurase, Isu1/2 scaffold, and Ssq1 chaperone.	Iron	35-39	cysteine desulfurase	Saccharomyces cerevisiae S288C	76-80
31040179-5	2019	The mitochondrial biosynthesis of (Fe-S)int required ISC components such as Nfs1 cysteine desulfurase, Isu1/2 scaffold, and Ssq1 chaperone.	Iron	35-39	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	124-128
31084022-4	2019	Emphasis is placed on how ligand design and exploration of fundamental organometallic chemistry coupled with mechanistic understanding have been used to discover iron catalysts for the hydrogen isotope exchange in pharmaceuticals and cobalt catalysts for C(sp2)-H borylation reactions.	Iron	162-166	Sp2 transcription factor	Homo sapiens	255-260
31092704-0	2019	Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism.	Iron	13-17	iron responsive element binding protein 2	Homo sapiens	72-76
31092704-12	2019	Based on these findings, we conclude that zinc-induced iron absorption involves elevation of DMT1 expression by stabilization of its mRNA, by a PI3K/IRP2-dependent mechanism.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	149-153
31020954-5	2019	Under the optimum conditions, the limits of detection were calculated as 0.08, 0.11, 0.12 and 0.17 mug L-1 for copper, iron, lead and zinc, respectively.	Iron	119-123	immunoglobulin kappa variable 1-16	Homo sapiens	103-106
31086893-1	2019	A significant abundance of copper (Cu) and iron in amyloid beta (Abeta) plaques, and several heme related metabolic disorders are directly correlated with Alzheimer"s disease (AD), and these together with co-localization of Abeta plaques with heme rich deposits in the brains of AD sufferers indicates a possible association of the said metals with the disease.	Iron	43-47	amyloid beta precursor protein	Homo sapiens	65-70
31231185-2	2019	The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI).	Iron	121-125	transferrin	Homo sapiens	225-236
31086893-1	2019	A significant abundance of copper (Cu) and iron in amyloid beta (Abeta) plaques, and several heme related metabolic disorders are directly correlated with Alzheimer"s disease (AD), and these together with co-localization of Abeta plaques with heme rich deposits in the brains of AD sufferers indicates a possible association of the said metals with the disease.	Iron	43-47	amyloid beta precursor protein	Homo sapiens	224-229
31231224-10	2019	Moreover, in vitro, baicalein could remarkably decrease ferroptotic indices (lipid reactive oxygen species, 4-hydroxynonenal, and prostaglandin endoperoxide synthase 2) and inhibit the expression of 12/15-lipoxygenase (12/15-LOX) in an iron-induced HT22 cell damage model.	Iron	236-240	arachidonate 15-lipoxygenase	Mus musculus	199-217
31231185-2	2019	The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI).	Iron	243-247	transferrin	Homo sapiens	225-236
30178147-5	2019	Meanwhile, birds in low-iron groups showed an increase in oxidative stress evidenced by the decreased catalase (CAT) activities and production of malonaldehyde (MDA) (P &lt; 0.05).	Iron	24-28	catalase	Anas platyrhynchos	102-110
30178147-5	2019	Meanwhile, birds in low-iron groups showed an increase in oxidative stress evidenced by the decreased catalase (CAT) activities and production of malonaldehyde (MDA) (P &lt; 0.05).	Iron	24-28	catalase	Anas platyrhynchos	112-115
30707893-0	2019	Impaired iPLA2beta activity affects iron uptake and storage without iron accumulation: An in vitro study excluding decreased iPLA2beta activity as the cause of iron deposition in PLAN.	Iron	36-40	phospholipase A2 group VI	Homo sapiens	9-18
31309086-1	2019	An increase in biochemical concentrations of non-transferrin bound iron (NTBI) within the patients with an increase in serum iron concentration was evaluated with the following objectives: (a) Iron overloading diseases/conditions with free radicle form of "iron containing" reactive oxygen species (ROS) and its imbalance mediated mortality, and (b) Intervention with iron containing drugs in context to increased redox iron concentration and treatment induced mortality.	Iron	67-71	transferrin	Homo sapiens	49-60
30978626-0	2019	Disease-specific patterns of basal ganglia neuronal activity in Neurodegeneration with Brain Iron Accumulation type I (NBIA-1).	Iron	93-97	pantothenate kinase 2	Homo sapiens	119-125
30707893-1	2019	PLA2G6-associated neurodegeneration (PLAN, NBIA2) is the second most common type of neurodegeneration with brain iron accumulation (NBIA), caused by recessive mutations of PLA2G6 gene, which encodes Ca2+-independent phospholipase A2beta (iPLA2beta).	Iron	113-117	phospholipase A2 group VI	Homo sapiens	0-6
31026585-1	2019	Heme oxygenase (HO)-1, a stress-inducible enzyme that converts heme into carbon monoxide (CO), iron and biliverdin, exerts important anti-inflammatory effects in activated macrophages.	Iron	95-99	heme oxygenase 1	Mus musculus	0-21
30707893-1	2019	PLA2G6-associated neurodegeneration (PLAN, NBIA2) is the second most common type of neurodegeneration with brain iron accumulation (NBIA), caused by recessive mutations of PLA2G6 gene, which encodes Ca2+-independent phospholipase A2beta (iPLA2beta).	Iron	113-117	phospholipase A2 group VI	Homo sapiens	43-48
30707893-1	2019	PLA2G6-associated neurodegeneration (PLAN, NBIA2) is the second most common type of neurodegeneration with brain iron accumulation (NBIA), caused by recessive mutations of PLA2G6 gene, which encodes Ca2+-independent phospholipase A2beta (iPLA2beta).	Iron	113-117	phospholipase A2 group VI	Homo sapiens	172-178
30707893-10	2019	Under the condition of decreased iPLA2beta activity, there was no obvious iron accumulation but iron uptake activity decreased and iron storage activity increased.	Iron	74-78	phospholipase A2 group VI	Homo sapiens	33-42
30707893-10	2019	Under the condition of decreased iPLA2beta activity, there was no obvious iron accumulation but iron uptake activity decreased and iron storage activity increased.	Iron	96-100	phospholipase A2 group VI	Homo sapiens	33-42
30707893-10	2019	Under the condition of decreased iPLA2beta activity, there was no obvious iron accumulation but iron uptake activity decreased and iron storage activity increased.	Iron	96-100	phospholipase A2 group VI	Homo sapiens	33-42
31143309-15	2019	Conclusions: Elevated Hgb and Hct levels in HH may be secondary to increased iron uptake by erythroid cell precursors in the bone marrow, in setting of increased availability of both transferrin-bound as well as non-transferrin-bound iron (NTBI).	Iron	77-81	transferrin	Homo sapiens	216-227
30426250-1	2019	Recent evidence on maintenance administration of epoetin beta pegol, a continuous erythropoiesis receptor activator (CERA), in dialysis patients shows the clinical benefit of bi-weekly administration (Q2W) in improving hematopoiesis and iron use efficiency.	Iron	237-241	erythropoietin	Homo sapiens	49-56
31143309-15	2019	Conclusions: Elevated Hgb and Hct levels in HH may be secondary to increased iron uptake by erythroid cell precursors in the bone marrow, in setting of increased availability of both transferrin-bound as well as non-transferrin-bound iron (NTBI).	Iron	234-238	transferrin	Homo sapiens	183-194
30918065-2	2019	Proprotein convertase subtilisin/kexin type 7 (PCSK7) gene variation has been associated with circulating lipids and liver damage during iron overload.	Iron	137-141	proprotein convertase subtilisin/kexin type 7	Homo sapiens	0-45
30884319-1	2019	The N-terminal fragment of Abeta (beta = beta) peptide is able to bind essential transition metal ions like, copper, zinc and iron.	Iron	126-130	amyloid beta precursor protein	Homo sapiens	27-45
30918065-2	2019	Proprotein convertase subtilisin/kexin type 7 (PCSK7) gene variation has been associated with circulating lipids and liver damage during iron overload.	Iron	137-141	proprotein convertase subtilisin/kexin type 7	Homo sapiens	47-52
30796750-0	2019	Post Translational Modulation of beta-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis.	Iron	112-116	amyloid beta precursor protein	Homo sapiens	33-63
30141000-1	2019	Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a genetic and early-onset neurodegenerative disorder characterized by iron accumulation in the basal ganglia.	Iron	129-133	pantothenate kinase 2	Homo sapiens	0-48
30796750-1	2019	Cell surface beta-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN).	Iron	88-92	amyloid beta precursor protein	Homo sapiens	13-43
30796750-1	2019	Cell surface beta-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN).	Iron	129-133	amyloid beta precursor protein	Homo sapiens	13-43
30768787-5	2019	CASE REPORT: We report a rare case of anti-N and anti-Doa immunoglobulin (Ig)G alloantibody-mediated life-threatening DHTR with hyperhemolysis in a patient with hemoglobin SS after RBC transfusion for acute chest syndrome who was successfully treated with eculizumab and HBOC-201 (Hemopure) in addition to steroids, IVIG, EPO, IV iron, and vitamin B12.	Iron	330-334	erythropoietin	Homo sapiens	6-9
30910397-9	2019	Iron-overload caused a graded increase (p &lt; 0.05) in serum iron, ferritin, transferrin, creatinine, urea, IL-6, TNF-alpha, TAC, MDA and NO levels as well as a reduction in albumin levels, renal SOD and GSH in groups 2 (iron 15 mg/kg) and 3 (iron 30 mg/kg) respectively compared to control.	Iron	0-4	transferrin	Rattus norvegicus	78-89
30910397-9	2019	Iron-overload caused a graded increase (p &lt; 0.05) in serum iron, ferritin, transferrin, creatinine, urea, IL-6, TNF-alpha, TAC, MDA and NO levels as well as a reduction in albumin levels, renal SOD and GSH in groups 2 (iron 15 mg/kg) and 3 (iron 30 mg/kg) respectively compared to control.	Iron	0-4	interleukin 6	Rattus norvegicus	109-113
30910397-9	2019	Iron-overload caused a graded increase (p &lt; 0.05) in serum iron, ferritin, transferrin, creatinine, urea, IL-6, TNF-alpha, TAC, MDA and NO levels as well as a reduction in albumin levels, renal SOD and GSH in groups 2 (iron 15 mg/kg) and 3 (iron 30 mg/kg) respectively compared to control.	Iron	0-4	tumor necrosis factor	Rattus norvegicus	115-124
31159519-8	2019	Similarly,the protein levels as well as mRNA expression of IL-6 and IL-17 in patients with iron overload were significantly higher than those in non-iron overload group (P&lt;0.01 both in PB and BM).	Iron	91-95	interleukin 6	Homo sapiens	59-63
31160026-0	2019	Removal of aqueous-phase Pb(II), Cd(II), As(III), and As(V) by nanoscale zero-valent iron supported on exhausted coffee grounds.	Iron	85-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	25-31
31159519-9	2019	Conclusions: As hematopoietic regulators secreted by Th17 cells, the expression of IL-6 and IL-17 in MDS patients with iron overload are elevated.	Iron	119-123	interleukin 6	Homo sapiens	83-87
31213851-0	2019	Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway.	Iron	63-67	interleukin 6	Homo sapiens	128-132
31213851-0	2019	Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway.	Iron	63-67	AKT serine/threonine kinase 1	Homo sapiens	138-141
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	66-70	interleukin 6	Homo sapiens	14-18
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	66-70	AKT serine/threonine kinase 1	Homo sapiens	24-27
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	132-136	interleukin 6	Homo sapiens	14-18
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	132-136	AKT serine/threonine kinase 1	Homo sapiens	24-27
30946834-8	2019	In addition, CB and FE promoted the translation of Nrf2 into nuclear and enhanced the activity of superoxide dismutase (SOD)/catalase, which confirmed cytoprotection against Abeta25-35-induced oxidative damage.	Iron	20-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	51-55
31172012-4	2019	More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds.	Iron	134-138	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	16-20
31172012-4	2019	More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds.	Iron	134-138	Yap6p	Saccharomyces cerevisiae S288C	97-101
30946834-8	2019	In addition, CB and FE promoted the translation of Nrf2 into nuclear and enhanced the activity of superoxide dismutase (SOD)/catalase, which confirmed cytoprotection against Abeta25-35-induced oxidative damage.	Iron	20-22	catalase	Rattus norvegicus	125-133
31137583-9	2019	Iron status was evaluated by both transferrin and ferritin levels, as well as by haemoglobin (Hb) concentration.	Iron	0-4	transferrin	Homo sapiens	34-45
30916671-1	2019	Human serum transferrin (hTF) is an iron binding protein with the primary task of ensuring well-controlled transport of Fe3+-ions in the bloodstream.	Iron	36-40	transferrin	Homo sapiens	12-23
31183007-1	2019	BACKGROUND: Congenital dyserythropoietic anemia type 1 (CDA1) is an autosomal recessive disorder of ineffective erythropoiesis, resulting in increased iron storage.	Iron	151-155	codanin 1	Homo sapiens	12-54
31118631-9	2019	The short-term iron imbalance initiated by AFP promoter regulation only occurred in hepatoma cells, resulting in signal contrast on MRI.	Iron	15-19	alpha fetoprotein	Homo sapiens	43-46
31183007-1	2019	BACKGROUND: Congenital dyserythropoietic anemia type 1 (CDA1) is an autosomal recessive disorder of ineffective erythropoiesis, resulting in increased iron storage.	Iron	151-155	codanin 1	Homo sapiens	56-60
31191795-2	2019	It has shown that wild-type p53 can reverse EMT back to epithelial characteristics, and iron chelator acting as a p53 inducer has been demonstrated.	Iron	88-92	tumor protein p53	Homo sapiens	114-117
30973710-0	2019	Transferrin Cycle and Clinical Roles of Citrate and Ascorbate in Improved Iron Metabolism.	Iron	74-78	transferrin	Homo sapiens	0-11
30973710-1	2019	Fe(III) delivery from blood plasma to cells via the transferrin (Tf) cycle was studied intensively due to its crucial role in Fe homeostasis.	Iron	0-2	transferrin	Homo sapiens	52-63
30973710-1	2019	Fe(III) delivery from blood plasma to cells via the transferrin (Tf) cycle was studied intensively due to its crucial role in Fe homeostasis.	Iron	0-2	transferrin	Homo sapiens	65-67
31101807-1	2019	The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP.	Iron	47-51	iron-sulfur cluster assembly enzyme	Homo sapiens	232-236
31101807-1	2019	The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP.	Iron	47-51	LYR motif containing 4	Homo sapiens	256-261
30791980-6	2019	Interestingly, Abeta40 generation was significantly increased by iron treatment in amyloid precursor protein (APP)-overexpressing fibroblasts, whereas Abeta42 generation did not change, which led to a decreased Abeta42/Abeta40 ratio.	Iron	65-69	amyloid beta precursor protein	Homo sapiens	83-108
31067696-0	2019	Deregulation of Hepatic Mek1/2-Erk1/2 Signaling Module in Iron Overload Conditions.	Iron	58-62	mitogen-activated protein kinase 3	Homo sapiens	31-37
31067696-5	2019	Our data demonstrate that hepatic iron overload associates with a decline in the activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) kinase (Mek1/2) pathway by selectively affecting the phosphorylation of Erk1/2.	Iron	34-38	mitogen-activated protein kinase 3	Homo sapiens	129-133
31067696-5	2019	Our data demonstrate that hepatic iron overload associates with a decline in the activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) kinase (Mek1/2) pathway by selectively affecting the phosphorylation of Erk1/2.	Iron	34-38	mitogen-activated protein kinase 3	Homo sapiens	251-257
31067696-6	2019	We propose that Mek1/2-Erk1/2 signaling is uncoupled from iron-Bmp-Smad-mediated hepcidin induction and that it may contribute to a number of liver pathologies in addition to toxic effects of iron.	Iron	192-196	mitogen-activated protein kinase 3	Homo sapiens	23-29
31052522-5	2019	The %&lt;EAR for iron and calcium also differed depending on race/ethnicity within PIR category (p &lt; 0.05).	Iron	17-21	pirin	Homo sapiens	83-86
30677788-2	2019	Hepcidin production, controlled by bone morphogenic protein 6 (BMP6), regulates iron homeostasis via interactions with the iron transporter, ferroportin.	Iron	80-84	bone morphogenetic protein 6	Homo sapiens	35-61
30677788-2	2019	Hepcidin production, controlled by bone morphogenic protein 6 (BMP6), regulates iron homeostasis via interactions with the iron transporter, ferroportin.	Iron	80-84	bone morphogenetic protein 6	Homo sapiens	63-67
30677788-9	2019	LY3113593 specifically blocked BMP6 binding to its receptor and produced increases in iron and transferrin saturation and decreases in hepcidin preclinically and clinically.	Iron	86-90	bone morphogenetic protein 6	Homo sapiens	31-35
30828802-0	2019	Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation.	Iron	0-4	transferrin	Homo sapiens	117-128
30792169-6	2019	Other approaches targeting iron dysregulation as mini-hepcidins, exogenous transferrin and erythroferrone inhibitors are in preclinical studies.	Iron	27-31	transferrin	Homo sapiens	75-86
30915432-9	2019	These results confirm that IRP2 is essential for regulation of iron metabolism in humans, and reveal a previously unrecognized subclass of neurodegenerative disease.	Iron	63-67	iron responsive element binding protein 2	Homo sapiens	27-31
30836435-5	2019	The use of interferon alpha and careful management of iron overload are reviewed and suggest the most favourable outcomes are achieved when CDA-I patients are managed with a holistic and multidisciplinary approach.	Iron	54-58	codanin 1	Homo sapiens	140-145
30877547-6	2019	The higher values for these parameters, 0.080 mol Einstein-1 and 0.152 mol Einstein-1, respectively, were obtained with 1.0 g L-1 of the catalyst with the higher iron content (17.6%).	Iron	162-166	immunoglobulin kappa variable 1-16	Homo sapiens	126-129
29907846-10	2019	In OW/OB women, there is an increase in Hb mass that likely increases iron requirements for erythropoiesis and circulating TfR mass.	Iron	70-74	cadherin 11	Homo sapiens	3-8
30818084-6	2019	Intracellular transferrin levels increase in PD, possibly as a consequence of oxidation of iron-containing prosthetic groups in mitochondria.	Iron	91-95	transferrin	Homo sapiens	14-25
30818084-7	2019	It is therefore conceivable that transferrin endocytic trafficking can contribute to noxious iron accumulation.	Iron	93-97	transferrin	Homo sapiens	33-44
30765134-10	2019	It was also found that TNF-alpha, GM-CSF and IFN-gamma productions from monocytes/macrophages of thalassemia patients who received iron chelator treatment were significantly higher than those produced from thalassemia patients without iron chelator treatment.	Iron	131-135	tumor necrosis factor	Homo sapiens	23-32
30765134-10	2019	It was also found that TNF-alpha, GM-CSF and IFN-gamma productions from monocytes/macrophages of thalassemia patients who received iron chelator treatment were significantly higher than those produced from thalassemia patients without iron chelator treatment.	Iron	131-135	interferon gamma	Homo sapiens	45-54
30765134-10	2019	It was also found that TNF-alpha, GM-CSF and IFN-gamma productions from monocytes/macrophages of thalassemia patients who received iron chelator treatment were significantly higher than those produced from thalassemia patients without iron chelator treatment.	Iron	235-239	interferon gamma	Homo sapiens	45-54
30370612-0	2019	Hepcidin and iron regulatory proteins coordinately regulate ferroportin 1 expression in the brain of mice.	Iron	13-17	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	60-73
31094165-9	2019	The reduced activity of antioxidative enzymes (catalase, superoxide dismutase and glutathione peroxidase) creates favorable conditions for the formation of cancer cell aggregates, which was shown in the rats whose diet was supplemented with iron.	Iron	241-245	catalase	Rattus norvegicus	47-55
30370612-3	2019	Ferroportin 1 (FPN1) is the currently only known iron exporter on the cell membrane.	Iron	49-53	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-13
30370612-3	2019	Ferroportin 1 (FPN1) is the currently only known iron exporter on the cell membrane.	Iron	49-53	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-19
30370612-4	2019	It has been indicated that the regulation of FPN1 in response to the alteration of iron level mainly involves two processes, posttranscriptional repression by iron regulatory proteins (IRPs) and posttranslational degradation by hepcidin, the major iron-sensing hormone.	Iron	83-87	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	45-49
30370612-4	2019	It has been indicated that the regulation of FPN1 in response to the alteration of iron level mainly involves two processes, posttranscriptional repression by iron regulatory proteins (IRPs) and posttranslational degradation by hepcidin, the major iron-sensing hormone.	Iron	159-163	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	45-49
30370612-4	2019	It has been indicated that the regulation of FPN1 in response to the alteration of iron level mainly involves two processes, posttranscriptional repression by iron regulatory proteins (IRPs) and posttranslational degradation by hepcidin, the major iron-sensing hormone.	Iron	159-163	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	45-49
30370612-9	2019	Further investigation disclosed that the compromised hepcidin-FPN1 regulation in IRP2-/- cells was directly dependent on the existence of iron-responsive element (IRE) in FPN1 messenger RNA.	Iron	138-142	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	62-66
30370612-9	2019	Further investigation disclosed that the compromised hepcidin-FPN1 regulation in IRP2-/- cells was directly dependent on the existence of iron-responsive element (IRE) in FPN1 messenger RNA.	Iron	138-142	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	171-175
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	FA complementation group C	Homo sapiens	46-49
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	nitric oxide synthase 2	Homo sapiens	113-117
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	interleukin 1 beta	Homo sapiens	119-127
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	interleukin 6	Homo sapiens	129-133
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	tumor necrosis factor	Homo sapiens	139-148
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	tumor necrosis factor	Homo sapiens	192-201
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	interleukin 1 beta	Homo sapiens	203-211
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	interleukin 6	Homo sapiens	217-221
30835899-6	2019	Furthermore, iron loading of macrophages in the presence of IL-4 led to the down-regulation of M2 markers: arginase-1, Mgl-1, and M2-specific transcriptional regulator, KLF4.	Iron	13-17	interleukin 4	Homo sapiens	60-64
30835899-7	2019	Iron loading of macrophages with IL-4 also resulted in reduced phosphorylation of STAT6, another transcriptional regulator of M2 activation.	Iron	0-4	interleukin 4	Homo sapiens	33-37
30835899-11	2019	Furthermore, NAFLD patients with hepatic RES iron deposition had increased hepatic gene expression levels of M1 markers, IL-6, IL-1beta, and CD40 and reduced gene expression of an M2 marker, TGM2, relative to patients with hepatocellular iron deposition pattern.	Iron	45-49	interleukin 6	Homo sapiens	121-125
30835899-11	2019	Furthermore, NAFLD patients with hepatic RES iron deposition had increased hepatic gene expression levels of M1 markers, IL-6, IL-1beta, and CD40 and reduced gene expression of an M2 marker, TGM2, relative to patients with hepatocellular iron deposition pattern.	Iron	45-49	interleukin 1 beta	Homo sapiens	127-135
30835899-11	2019	Furthermore, NAFLD patients with hepatic RES iron deposition had increased hepatic gene expression levels of M1 markers, IL-6, IL-1beta, and CD40 and reduced gene expression of an M2 marker, TGM2, relative to patients with hepatocellular iron deposition pattern.	Iron	45-49	transglutaminase 2	Homo sapiens	191-195
31276102-3	2019	Here, we show that Nrf2 is activated by iron-induced, mitochondria-derived pro-oxidants and drives Bmp6 expression in liver sinusoid endothelial cells, which in turn increases hepcidin synthesis by neighbouring hepatocytes.	Iron	40-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
31145335-5	2019	Transferrin saturation was calculated as 100x serum iron/TIBC.	Iron	52-56	transferrin	Homo sapiens	0-11
31276102-4	2019	In Nrf2 knockout mice, the Bmp6-hepcidin response to oral and parenteral iron is impaired and iron accumulation and hepatic damage are increased.	Iron	73-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	3-7
31276102-0	2019	Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.	Iron	14-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
31276102-4	2019	In Nrf2 knockout mice, the Bmp6-hepcidin response to oral and parenteral iron is impaired and iron accumulation and hepatic damage are increased.	Iron	94-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	3-7
31276102-5	2019	Pharmacological activation of Nrf2 stimulates the Bmp6-hepcidin axis, improving iron homeostasis in haemochromatosis and counteracting the inhibition of Bmp6 by erythroferrone in beta-thalassaemia.	Iron	80-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
31276102-6	2019	We propose that Nrf2 links cellular sensing of excess toxic iron to control of systemic iron homeostasis and antioxidant responses, and may be a therapeutic target for iron-associated disorders.	Iron	60-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
31276102-6	2019	We propose that Nrf2 links cellular sensing of excess toxic iron to control of systemic iron homeostasis and antioxidant responses, and may be a therapeutic target for iron-associated disorders.	Iron	88-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
31276102-6	2019	We propose that Nrf2 links cellular sensing of excess toxic iron to control of systemic iron homeostasis and antioxidant responses, and may be a therapeutic target for iron-associated disorders.	Iron	88-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
31091209-1	2019	OBJECTIVES: We have investigated the efficacy of mono- and combined therapy with green tea extract (GTE) in mobilizing redox iron, scavenging reactive oxygen species (ROS), and improving insulin production in iron-loaded pancreatic cells.	Iron	209-213	insulin	Homo sapiens	187-194
30796516-3	2019	In the placenta, iron is taken up from Fe-transferrin through the transferrin receptor being the ion an important nutrient during pregnancy and also for Toxoplasma gondii proliferation.	Iron	17-21	transferrin	Homo sapiens	42-53
30796516-3	2019	In the placenta, iron is taken up from Fe-transferrin through the transferrin receptor being the ion an important nutrient during pregnancy and also for Toxoplasma gondii proliferation.	Iron	17-21	transferrin	Homo sapiens	66-77
31091209-7	2019	CONCLUSIONS: Green tea EGCG ameliorated oxidative damage of iron-loaded beta-cells by removing redox iron and free radicals and attenuating insulin production.	Iron	60-64	insulin	Homo sapiens	140-147
30683366-2	2019	Immobilization of CdTe quantum dots (QDs) on TiO2 nanotube arrays (TNAs), addition of iron (III) and adenosine triphosphate (ATP) in turn can effectively adjust the photocurrent response of TNAs under visible light irradiation due to a photo-excited electron transfer process, and alkaline phosphatase (ALP) activity can be determined for its catalysis toward dephosphorylation of ATP.	Iron	86-90	alkaline phosphatase, placental	Homo sapiens	281-301
30957431-2	2019	Herein, a Co-engineered FeOOH catalyst integrated on carbon fiber paper (Co-FeOOH/CFP) is reported, which realized a great improvement of the oxygen evolution activity by tuning the coordination geometry of the Fe species with an electrochemically driven method.	Iron	24-26	complement factor properdin	Homo sapiens	82-85
30683366-2	2019	Immobilization of CdTe quantum dots (QDs) on TiO2 nanotube arrays (TNAs), addition of iron (III) and adenosine triphosphate (ATP) in turn can effectively adjust the photocurrent response of TNAs under visible light irradiation due to a photo-excited electron transfer process, and alkaline phosphatase (ALP) activity can be determined for its catalysis toward dephosphorylation of ATP.	Iron	86-90	alkaline phosphatase, placental	Homo sapiens	303-306
31105516-7	2019	By promoting erythropoiesis, EPO influences iron metabolism and induces shifts in iron pool which may ameliorate conditions of free iron excess and iron accumulation.	Iron	44-48	erythropoietin	Homo sapiens	29-32
30861546-2	2019	Epidemiological studies have found a significant negative association of transferrin (Tf) saturation and cardiovascular events suggesting that higher body iron possibly confer a protective effect towards developing cardiovascular events.	Iron	155-159	transferrin	Homo sapiens	73-84
30971398-0	2019	Glia maturation factor-gamma regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS.	Iron	57-61	glia maturation factor, gamma	Mus musculus	0-28
30971398-3	2019	Here, we explored the important role of the actin-regulatory protein glia maturation factor-gamma (GMFG) in the regulation of cellular iron metabolism and macrophage phenotype.	Iron	135-139	glia maturation factor, gamma	Mus musculus	69-97
30971398-3	2019	Here, we explored the important role of the actin-regulatory protein glia maturation factor-gamma (GMFG) in the regulation of cellular iron metabolism and macrophage phenotype.	Iron	135-139	glia maturation factor, gamma	Mus musculus	99-103
30971398-4	2019	We found that GMFG was downregulated in murine macrophages by exposure to iron and hydrogen peroxide.	Iron	74-78	glia maturation factor, gamma	Mus musculus	14-18
30971398-5	2019	GMFG knockdown altered the expression of iron metabolism proteins and increased iron levels in murine macrophages and concomitantly promoted their polarization toward an anti-inflammatory M2 phenotype.	Iron	41-45	glia maturation factor, gamma	Mus musculus	0-4
30971398-5	2019	GMFG knockdown altered the expression of iron metabolism proteins and increased iron levels in murine macrophages and concomitantly promoted their polarization toward an anti-inflammatory M2 phenotype.	Iron	80-84	glia maturation factor, gamma	Mus musculus	0-4
30971398-6	2019	GMFG-knockdown macrophages exhibited moderately increased levels of mitochondrial reactive oxygen species (mtROS), which were accompanied by decreased expression of some mitochondrial respiration chain components, including the iron-sulfur cluster assembly scaffold protein ISCU as well as the antioxidant enzymes SOD1 and SOD2.	Iron	228-232	glia maturation factor, gamma	Mus musculus	0-4
30971398-7	2019	Importantly, treatment of GMFG-knockdown macrophages with the antioxidant N-acetylcysteine reversed the altered expression of iron metabolism proteins and significantly inhibited the enhanced gene expression of M2 macrophage markers, suggesting that mtROS is mechanistically linked to cellular iron metabolism and macrophage phenotype.	Iron	126-130	glia maturation factor, gamma	Mus musculus	26-30
30971398-7	2019	Importantly, treatment of GMFG-knockdown macrophages with the antioxidant N-acetylcysteine reversed the altered expression of iron metabolism proteins and significantly inhibited the enhanced gene expression of M2 macrophage markers, suggesting that mtROS is mechanistically linked to cellular iron metabolism and macrophage phenotype.	Iron	294-298	glia maturation factor, gamma	Mus musculus	26-30
30971398-9	2019	Our findings suggest that GMFG is an important regulator in cellular iron metabolism and macrophage phenotype and could be a novel therapeutic target for modulating macrophage function in immune and metabolic disorders.	Iron	69-73	glia maturation factor, gamma	Mus musculus	26-30
31010126-0	2019	The Association of TMPRSS6 Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia.	Iron	49-53	transmembrane serine protease 6	Homo sapiens	19-26
31010126-0	2019	The Association of TMPRSS6 Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia.	Iron	66-70	transmembrane serine protease 6	Homo sapiens	19-26
31010126-1	2019	Multiple common variants in transmembrane protease serine 6 (TMPRSS6) were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly taking account of iron intake.	Iron	102-106	transmembrane serine protease 6	Homo sapiens	28-59
31010126-1	2019	Multiple common variants in transmembrane protease serine 6 (TMPRSS6) were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly taking account of iron intake.	Iron	102-106	transmembrane serine protease 6	Homo sapiens	61-68
31010126-1	2019	Multiple common variants in transmembrane protease serine 6 (TMPRSS6) were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly taking account of iron intake.	Iron	209-213	transmembrane serine protease 6	Homo sapiens	28-59
31010126-1	2019	Multiple common variants in transmembrane protease serine 6 (TMPRSS6) were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly taking account of iron intake.	Iron	209-213	transmembrane serine protease 6	Homo sapiens	61-68
31010126-2	2019	This study aims to investigate whether TMPRSS6 SNPs (rs855791 and rs4820268) and iron intake are associated with a low iron and hemoglobin concentration in under-two-year-old children.	Iron	119-123	transmembrane serine protease 6	Homo sapiens	39-46
30740789-1	2019	An ice/salt-assisted strategy has been developed to achieve the green and efficient synthesis of ultrathin two-dimensional (2D) micro/mesoporous carbon nanosheets (CNS) with the dominant active moieties of Fe-N4 (Fe-N-CNS) as high-performance electrocatalysts for the oxygen reduction reaction (ORR).	Iron	206-210	carboxylesterase 2	Homo sapiens	3-6
30173408-4	2019	In the current work, we describe that fibroblasts derived from patients harbouring PANK2 mutations can reproduce many of the cellular pathological alterations found in the disease, such as intracellular iron and lipofuscin accumulation, increased oxidative stress, and mitochondrial dysfunction.	Iron	203-207	pantothenate kinase 2	Homo sapiens	83-88
31034471-1	2019	As a component of the Cytosolic Iron-sulfur cluster Assembly (CIA) pathway, DRE2 is essential in organisms from yeast to mammals.	Iron	32-36	electron carrier DRE2	Saccharomyces cerevisiae S288C	76-80
31034524-5	2019	We evaluated iron, using ferric citrate, as another essential factor for cell growth and efficient PHA production and confirmed that PHA production in R. sulfidophilum was growth-associated under microaerobic and photoheterotrophic conditions.	Iron	13-17	lamin B receptor	Homo sapiens	99-102
31034524-5	2019	We evaluated iron, using ferric citrate, as another essential factor for cell growth and efficient PHA production and confirmed that PHA production in R. sulfidophilum was growth-associated under microaerobic and photoheterotrophic conditions.	Iron	13-17	lamin B receptor	Homo sapiens	133-136
31034524-6	2019	In fact, a subtle amount of iron (1 to 2 muM) was sufficient to promote rapid cell growth and biomass accumulation, as well as a high PHA volumetric productivity during the logarithmic phase.	Iron	28-32	lamin B receptor	Homo sapiens	134-137
31034524-8	2019	Thus, we successfully confirmed that an optimum concentration of iron, an essential nutrient, promotes cell growth in R. sulfidophilum and also enhances PHA utilization.	Iron	65-69	lamin B receptor	Homo sapiens	153-156
30833328-0	2019	Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin-cubilin complex and transferrin receptor 1.	Iron	60-64	transferrin	Rattus norvegicus	16-27
30933555-1	2019	HSPA9, the gene coding for the mitochondrial chaperone mortalin, is involved in various cellular roles such as mitochondrial protein import, folding, degradation, Fe-S cluster biogenesis, mitochondrial homeostasis, and regulation of the antiapoptotic protein p53.	Iron	163-167	heat shock protein family A (Hsp70) member 9	Homo sapiens	0-5
30860388-0	2019	Stereospecific Iron-Catalyzed Carbon(sp2)-Carbon(sp3) Cross-Coupling with Alkyllithium and Alkenyl Iodides.	Iron	15-19	Sp2 transcription factor	Homo sapiens	37-40
30860388-0	2019	Stereospecific Iron-Catalyzed Carbon(sp2)-Carbon(sp3) Cross-Coupling with Alkyllithium and Alkenyl Iodides.	Iron	15-19	Sp3 transcription factor	Homo sapiens	49-52
30996139-0	2019	Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes.	Iron	68-72	transferrin	Homo sapiens	50-61
31105516-7	2019	By promoting erythropoiesis, EPO influences iron metabolism and induces shifts in iron pool which may ameliorate conditions of free iron excess and iron accumulation.	Iron	82-86	erythropoietin	Homo sapiens	29-32
31105516-7	2019	By promoting erythropoiesis, EPO influences iron metabolism and induces shifts in iron pool which may ameliorate conditions of free iron excess and iron accumulation.	Iron	82-86	erythropoietin	Homo sapiens	29-32
31105516-7	2019	By promoting erythropoiesis, EPO influences iron metabolism and induces shifts in iron pool which may ameliorate conditions of free iron excess and iron accumulation.	Iron	82-86	erythropoietin	Homo sapiens	29-32
31087924-5	2019	When 1 mmol L-1 formic acid was used and the initial concentration of U(VI) was 50 mg L-1, MIL-53(Fe) achieved a high reduction rate of 80% after 2 hours of visible light exposure.	Iron	98-100	immunoglobulin kappa variable 1-16	Homo sapiens	12-15
30995819-1	2019	Erythroferrone (ERFE) is a hepcidin inhibitor whose synthesis is stimulated by erythropoietin, which increases iron absorption and mobilization.	Iron	111-115	erythropoietin	Homo sapiens	79-93
30950264-2	2019	Herein we report the synthesis and investigations of the photophysics of mer and fac iron complexes bearing bidentate pyridyl-NHC ligands, coordinating the iron with three ligand-field-enhancing carbene bonds.	Iron	85-89	FA complementation group C	Homo sapiens	81-84
30950264-2	2019	Herein we report the synthesis and investigations of the photophysics of mer and fac iron complexes bearing bidentate pyridyl-NHC ligands, coordinating the iron with three ligand-field-enhancing carbene bonds.	Iron	156-160	FA complementation group C	Homo sapiens	81-84
30950264-7	2019	Our results clearly highlight the impact of bidentate pyridyl-NHC ligands on the photophysics of iron complexes, especially the paramount role of fac/ mer isomerism in modulating the overall decay process, which can be potentially exploited in the design of new Fe(II)-based photoactive compounds.	Iron	97-101	FA complementation group C	Homo sapiens	146-149
31114204-7	2019	The expression of iron-containing enzymes (catalase and aconitase) and non-ferrous enzymes (protein kinase A) was measured with Western blotting and ELISA.	Iron	18-22	catalase	Rattus norvegicus	43-51
32039344-3	2019	Here, we describe affinity isolation-based target identification efforts which yielded pirin, an iron-dependent cotranscription factor, as a target of this series of compounds.	Iron	97-101	pirin	Homo sapiens	87-92
31087924-5	2019	When 1 mmol L-1 formic acid was used and the initial concentration of U(VI) was 50 mg L-1, MIL-53(Fe) achieved a high reduction rate of 80% after 2 hours of visible light exposure.	Iron	98-100	immunoglobulin kappa variable 1-16	Homo sapiens	86-89
30737351-8	2019	DndCDE with an intact iron-sulfur cluster (DndCDE-FeS) possessed H2O2 decomposition activity, with a V max of 10.58 +- 0.90 mM min-1 and a half-saturation constant, K 0.5S, of 31.03 mM.	Iron	50-53	CD59 molecule (CD59 blood group)	Homo sapiens	127-132
31040664-0	2019	Targeted Fe-doped silica nanoparticles as a novel ultrasound-magnetic resonance dual-mode imaging contrast agent for HER2-positive breast cancer.	Iron	9-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-121
30193381-0	2019	Cord Blood Erythropoietin and Hepcidin Reflect Lower Newborn Iron Stores due to Maternal Obesity during Pregnancy.	Iron	61-65	erythropoietin	Homo sapiens	11-25
30193381-2	2019	In adults, both iron depletion and hypoxia stimulate erythropoietin (Epo) production, while hepcidin, the primary iron regulator, is inhibited by Epo and stimulated by obesity.	Iron	16-20	erythropoietin	Homo sapiens	53-67
30193381-2	2019	In adults, both iron depletion and hypoxia stimulate erythropoietin (Epo) production, while hepcidin, the primary iron regulator, is inhibited by Epo and stimulated by obesity.	Iron	16-20	erythropoietin	Homo sapiens	69-72
30193381-2	2019	In adults, both iron depletion and hypoxia stimulate erythropoietin (Epo) production, while hepcidin, the primary iron regulator, is inhibited by Epo and stimulated by obesity.	Iron	114-118	erythropoietin	Homo sapiens	146-149
30193381-3	2019	To understand this relationship in fetuses, we investigated obesity, inflammation, and fetal iron status on fetal Epo and hepcidin levels.	Iron	93-97	erythropoietin	Homo sapiens	114-117
30291962-4	2019	We investigated the role of a lysine-rich sequence (KKK653-655) 20 amino acids upstream of the C-terminus unique to 5-LOX that might displace the main-chain carboxylate in the iron coordination sphere.	Iron	176-180	arachidonate 5-lipoxygenase	Homo sapiens	116-121
31057960-3	2019	It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status.	Iron	287-291	interleukin 6	Homo sapiens	210-214
31057960-3	2019	It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status.	Iron	287-291	interleukin 6	Homo sapiens	210-214
30709903-0	2019	Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB.	Iron	0-4	cAMP responsive element binding protein 1	Mus musculus	135-139
30709903-8	2019	Of note, iron increased the occupancy of pCREB and decreased the occupancy of O-GlcNAcylated CREB on the leptin promoter.	Iron	9-13	cAMP responsive element binding protein 1	Mus musculus	42-46
30709903-10	2019	We conclude that iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB.	Iron	17-21	cAMP responsive element binding protein 1	Mus musculus	58-62
30709903-10	2019	We conclude that iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB.	Iron	17-21	cAMP responsive element binding protein 1	Mus musculus	101-105
30681741-7	2019	After treatment with intravenous iron, endogenous thrombin potential and peak height decreased in IDA patients by a mean of 122 4 nmol/l/min (95% confidence interval [CI]: 17 9-227, P = 0 023) and 51 9 (95% CI: 26 6-77 2, P &lt; 0 001) respectively.	Iron	33-37	coagulation factor II, thrombin	Homo sapiens	50-58
30677469-10	2019	Altered cardiac expression of hepcidin and other iron-related genes is driven by iron-independent stimuli in the failing heart.	Iron	49-53	hepcidin antimicrobial peptide	Rattus norvegicus	30-38
30677469-10	2019	Altered cardiac expression of hepcidin and other iron-related genes is driven by iron-independent stimuli in the failing heart.	Iron	81-85	hepcidin antimicrobial peptide	Rattus norvegicus	30-38
30806852-2	2019	In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury.	Iron	12-16	transferrin	Homo sapiens	58-69
30806852-2	2019	In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury.	Iron	12-16	transferrin	Homo sapiens	90-101
30806852-2	2019	In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury.	Iron	108-112	transferrin	Homo sapiens	90-101
30806852-9	2019	Furthermore, ZIP14 silencing decreased 55Fe uptake after 55Fe-Transferrin exposure (p &lt; 0.05), suggesting ZIP14 could be involved in early endosomal transport of TBI-derived iron into the cytosol.	Iron	177-181	transferrin	Homo sapiens	62-73
30014284-8	2019	Moreover, thallium and iron were inversely associated with insulin levels.	Iron	23-27	insulin	Homo sapiens	59-66
30970527-8	2019	Hepcidin expression was negatively correlated to erythrocytic indices and iron profile, while it was positively correlated to serum TNF-alpha and IL-6 levels.	Iron	74-78	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
30878383-8	2019	Also, the presence of a moderate concentration of iron chelator deferoximine improves the conservation of total CD34+ cells and committed progenitors in air condition.	Iron	50-54	CD34 molecule	Homo sapiens	112-116
30931929-0	2019	Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway.	Iron	0-4	signal transducer and activator of transcription 3	Homo sapiens	86-91
30931929-2	2019	Iron directly binds CDK1, which is upregulated in several cancers, thereby promoting JAK1 phosphorylation and activation of STAT3 signaling to promote colorectal carcinogenesis.	Iron	0-4	Janus kinase 1	Homo sapiens	85-89
30931929-2	2019	Iron directly binds CDK1, which is upregulated in several cancers, thereby promoting JAK1 phosphorylation and activation of STAT3 signaling to promote colorectal carcinogenesis.	Iron	0-4	signal transducer and activator of transcription 3	Homo sapiens	124-129
30931929-3	2019	This study aimed to investigate the role of iron/CDK1/STAT3 signaling in lung carcinogenesis.	Iron	44-48	signal transducer and activator of transcription 3	Homo sapiens	54-59
30931929-4	2019	We found that iron-dependent CDK1 activity upregulated IL-6 receptor subunit GP130 post-transcriptionally via phosphorylation of 4E-BP1, which is critical for activation of JAK/STAT3 signaling.	Iron	14-18	signal transducer and activator of transcription 3	Homo sapiens	177-182
30931929-5	2019	CDK1 and STAT3 are essential for iron-mediated colony formation in lung cancer cell lines.	Iron	33-37	signal transducer and activator of transcription 3	Homo sapiens	9-14
30931929-6	2019	CDK1 knockdown and iron chelator DFO decreased tumorigenicity and GP130/STAT3 signaling in vivo.	Iron	19-23	signal transducer and activator of transcription 3	Homo sapiens	72-77
30931929-8	2019	Altogether, the present results suggest that CDK1 inhibition and iron deprivation are potential strategies to target GP130/STAT3 signaling to suppress lung cancer.	Iron	65-69	signal transducer and activator of transcription 3	Homo sapiens	123-128
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Iron	29-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Iron	124-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30640524-4	2019	We present evidence that both pathways of GAPDH membrane trafficking are up-regulated upon iron starvation, potentially by mobilization of intracellular calcium.	Iron	91-95	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	56-60	interleukin 6	Mus musculus	137-141
30945556-4	2019	Another related TTSP, matriptase-2 is expressed in the liver and functions by regulating iron homoeostasis through the cleavage of hemojuvelin and thus is implicated in iron overload diseases.	Iron	89-93	transmembrane serine protease 6	Homo sapiens	22-34
30945556-4	2019	Another related TTSP, matriptase-2 is expressed in the liver and functions by regulating iron homoeostasis through the cleavage of hemojuvelin and thus is implicated in iron overload diseases.	Iron	169-173	transmembrane serine protease 6	Homo sapiens	22-34
30507031-4	2019	Type 2-5 FE are secondary FEs caused by mutations of genes involved in oxygen sensing pathway important for erythropoietin (EPO) regulation.	Iron	26-29	erythropoietin	Homo sapiens	108-122
30507031-4	2019	Type 2-5 FE are secondary FEs caused by mutations of genes involved in oxygen sensing pathway important for erythropoietin (EPO) regulation.	Iron	26-29	erythropoietin	Homo sapiens	124-127
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	56-60	signal transducer and activator of transcription 3	Mus musculus	142-147
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	105-109	interleukin 6	Mus musculus	137-141
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	105-109	signal transducer and activator of transcription 3	Mus musculus	142-147
30370692-6	2019	We also provide evidence that under uninflamed conditions, the regulation of Fpn1 and TfR1 expression by H 2 S, both in vivo and in vitro, are mediated by the nitric oxide (NO)/Nrf2 and iron regulatory protein/iron responsive element pathways, respectively, which are independent of IL-6/pSTAT3/hepcidin signals.	Iron	186-190	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	77-81
30370692-6	2019	We also provide evidence that under uninflamed conditions, the regulation of Fpn1 and TfR1 expression by H 2 S, both in vivo and in vitro, are mediated by the nitric oxide (NO)/Nrf2 and iron regulatory protein/iron responsive element pathways, respectively, which are independent of IL-6/pSTAT3/hepcidin signals.	Iron	210-214	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	77-81
30604643-3	2019	We selected the more promising candidate (H7), based on its ability to inhibit TfR1-mediated iron-loaded transferrin internalization in Raji cells (B-cell lymphoma).	Iron	93-97	transferrin	Homo sapiens	105-116
30877170-6	2019	In addition, dysregulation of FBXL5-mediated cellular iron homeostasis was found to be associated with poor prognosis in human HCC, suggesting that FBXL5 plays a key role in defense against hepatocarcinogenesis.	Iron	54-58	F-box and leucine rich repeat protein 5	Homo sapiens	30-35
30877170-6	2019	In addition, dysregulation of FBXL5-mediated cellular iron homeostasis was found to be associated with poor prognosis in human HCC, suggesting that FBXL5 plays a key role in defense against hepatocarcinogenesis.	Iron	54-58	F-box and leucine rich repeat protein 5	Homo sapiens	148-153
30027341-0	2019	Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in Differentiated Neuronal-Like PC12 Cells Subjected to Iron Challenge.	Iron	118-122	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
30027341-2	2019	The objective of the current work was to investigate how cellular iron status affects the expression of the ferroportin gene Fpn under the influence of hepcidin, known to post-translational lower the available ferroportin protein.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	152-160
30128649-0	2019	Correction to: Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in Differentiated Neuronal-like PC12 Cells Subjected to Iron Challenge.	Iron	133-137	hepcidin antimicrobial peptide	Rattus norvegicus	15-23
30963028-12	2019	Conclusion: Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis.	Iron	191-195	transferrin	Homo sapiens	135-146
31032672-8	2019	Positive correlation was found between malondialdehyde (MDA), IL8, IL13 and iron load, transfusion frequency/duration, total leucocyte count and lymphocyte (%).	Iron	76-80	interleukin 13	Homo sapiens	67-71
30934679-6	2019	A set of bidisperse MRG samples are firstly prepared by adjusting the weight percentage of the plate-like CI particles and mixing with the spherical CI particles.	Iron	106-108	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	20-23
30934679-6	2019	A set of bidisperse MRG samples are firstly prepared by adjusting the weight percentage of the plate-like CI particles and mixing with the spherical CI particles.	Iron	149-151	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	20-23
30944864-7	2019	In multivariate analysis, C-reactive protein was the dominant predictor of hepcidin and contributed to iron blockade even at very low levels.	Iron	103-107	C-reactive protein	Homo sapiens	26-44
30807173-10	2019	Raman spectra suggest that both oxidation and spin state of heme iron change when cyt c is adsorbed on SNPs but not on SNPs-APTES.	Iron	65-69	cytochrome c, somatic	Homo sapiens	82-87
30778722-0	2019	The mitochondrial copper chaperone COX19 influences copper and iron homeostasis in arabidopsis.	Iron	63-67	Cox19p	Saccharomyces cerevisiae S288C	35-40
30778722-1	2019	KEY MESSAGE: The mitochondrial metallochaperone COX19 influences iron and copper responses highlighting a role of mitochondria in modulating metal homeostasis in Arabidopsis.	Iron	65-69	Cox19p	Saccharomyces cerevisiae S288C	48-53
30778722-11	2019	The results indicate that the mitochondrial copper chaperone COX19 has a role in regulating copper and iron homeostasis and responses in plants.	Iron	103-107	Cox19p	Saccharomyces cerevisiae S288C	61-66
30971879-8	2019	(3) In CSF, the IL-6 level was increased as the iron level was elevated in the PD-TD group (r = 0.308, P = 0.022).	Iron	48-52	interleukin 6	Homo sapiens	16-20
30917125-12	2019	PRS-080#22 dose-dependently mobilized serum iron with increases in both serum iron concentration and transferrin saturation.	Iron	44-48	transferrin	Homo sapiens	101-112
30963028-8	2019	Results: WES revealed gene variants involved in iron absorption and transport, in the transmembrane protease, serine 6 (TMPRSS6) and transferrin (TF) genes; multiple genetic variants in CUBN, which encodes cubilin (a receptor involved in the absorption of vitamin B12 as well as the reabsorption of transferrin-bound iron and vitamin D in the kidneys); SLC25A37 (involved in iron transport into mitochondria) and CD163 (a scavenger receptor involved in hemorrhage resolution).	Iron	48-52	transferrin	Homo sapiens	146-148
30963028-12	2019	Conclusion: Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis.	Iron	153-157	transferrin	Homo sapiens	135-146
30963028-12	2019	Conclusion: Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis.	Iron	191-195	transferrin	Homo sapiens	135-146
30949015-6	2019	Insulin signaling and iron metabolism are interconnected, as high tissue iron stores are associated with insulin resistance, and conversely, impaired insulin signaling may lead to iron accumulation in an affected tissue.	Iron	73-77	insulin	Homo sapiens	0-7
30949015-6	2019	Insulin signaling and iron metabolism are interconnected, as high tissue iron stores are associated with insulin resistance, and conversely, impaired insulin signaling may lead to iron accumulation in an affected tissue.	Iron	73-77	insulin	Homo sapiens	0-7
30579903-6	2019	Expression of an iron-binding nuclear protein-related gene (pirin) was the most up-regulated in the WCSC-treated cells with enhanced expression of antioxidant-related genes, whereas expression of carbonic anhydrase IX gene, a marker of tumor hypoxia, was the most down-regulated.	Iron	17-21	pirin	Homo sapiens	60-65
30929390-4	2019	Among them, 7 MDS patients with Low/Int-1 have received iron chelation therapy for 6 months during two MRI examinations.	Iron	56-60	Wnt family member 1	Homo sapiens	36-41
30874600-3	2019	Treatment of primary adult and neonatal cardiomyocytes as well as H9c2 cells with iron decreased insulin sensitivity determined via Western blotting or immunofluorescent detection of Akt and p70S6K phosphorylation and glucose uptake.	Iron	82-86	AKT serine/threonine kinase 1	Rattus norvegicus	183-186
30874600-6	2019	Western blotting for LC3-I, LC3-II and P62 levels as well as immunofluorescent co-detection of autophagosomes with Cyto-ID and lysosomal cathepsin activity indicated that iron attenuated autophagic flux without altering total expression of Atg7 or beclin-1 and phosphorylation of mTORC1 and ULK1.	Iron	171-175	unc-51 like autophagy activating kinase 1	Rattus norvegicus	291-295
30929390-13	2019	After iron chelation therapy, the values of SF, transferrin saturation, ALT, AST, pro-BNP and LIC of 7 patients were decreased compared with values before iron chelation therapy, and the peripheral blood cell level was increased.	Iron	6-10	transferrin	Homo sapiens	48-59
30929390-13	2019	After iron chelation therapy, the values of SF, transferrin saturation, ALT, AST, pro-BNP and LIC of 7 patients were decreased compared with values before iron chelation therapy, and the peripheral blood cell level was increased.	Iron	6-10	solute carrier family 17 member 5	Homo sapiens	77-80
30836628-7	2019	(3) Results: A one unit increase in neonatal WB-Iron was associated with a 38% decrease in mean interleukin (IL)-6 levels (0.62; 95% CI: 0.40-0.95, p = 0.03), and a 37% decrease in mean MBL levels (0.63; 95% CI: 0.41-0.95, p = 0.03), but was not statistically significant after correction for multiple testing.	Iron	48-52	interleukin 6	Homo sapiens	96-114
30713077-0	2019	CIPK11-Dependent Phosphorylation Modulates FIT Activity to Promote Arabidopsis Iron Acquisition in Response to Calcium Signaling.	Iron	79-83	SOS3-interacting protein 4	Arabidopsis thaliana	0-6
30713077-5	2019	cipk11 mutant plants display compromised root Fe mobilization and seed Fe content.	Iron	46-48	SOS3-interacting protein 4	Arabidopsis thaliana	0-6
30713077-5	2019	cipk11 mutant plants display compromised root Fe mobilization and seed Fe content.	Iron	71-73	SOS3-interacting protein 4	Arabidopsis thaliana	0-6
30713077-6	2019	Fe uptake is dependent on CBL1/CBL9.	Iron	0-2	calcineurin B-like protein 9	Arabidopsis thaliana	31-35
30713077-7	2019	CIPK11 phosphorylates FIT at Ser272, and mutation of this target site modulates FIT nuclear accumulation, homo-dimerization, interaction with bHLH039, and transcriptional activity and affects the plant"s Fe-uptake ability.	Iron	204-206	SOS3-interacting protein 4	Arabidopsis thaliana	0-6
30850661-1	2019	Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin.	Iron	47-51	transferrin	Homo sapiens	6-17
30850661-1	2019	Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin.	Iron	47-51	transferrin	Homo sapiens	102-113
30850661-1	2019	Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin.	Iron	90-94	transferrin	Homo sapiens	6-17
30850661-1	2019	Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin.	Iron	90-94	transferrin	Homo sapiens	102-113
30836628-8	2019	(4) Conclusions: In summary, we found that higher neonatal WB-iron content was inversely associated with IL-6 and MBL, which may increase susceptibility to infections.	Iron	62-66	interleukin 6	Homo sapiens	105-109
30906244-2	2019	Serum melanotransferrin (MTf), a transferrin homolog capable of reversibly binding iron, has been proposed as a biochemical marker of AD.	Iron	83-87	transferrin	Homo sapiens	12-23
30984307-0	2019	Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease.	Iron	78-82	transmembrane serine protease 6	Homo sapiens	43-50
30709968-8	2019	Iron grounds volume in PAG was correlated with higher plasma levels of soluble tumor necrosis factor-like WEAK (r = 0.395, p = 0.005) and cellular fibronectin (r = 0.294, p = 0.040).	Iron	0-4	fibronectin 1	Homo sapiens	147-158
30700131-4	2019	This process was abrogated by iron via induction of H-ferritin as reflected by lowering ALP and osteocalcin secretion and preventing extracellular calcium deposition.	Iron	30-34	bone gamma-carboxyglutamate protein	Homo sapiens	96-107
30589442-6	2019	Body mass index (BMI) and biomarkers of metabolic syndrome, inflammation, and iron stores were used in logistic regression with abnormality in serum GGT, alanine aminotransferase (ALT), or aspartate aminotransferase (AST) as outcomes.	Iron	78-82	solute carrier family 17 member 5	Homo sapiens	189-215
30623722-6	2019	In patients with systemic iron overload, increased urinary iron levels were associated with elevated circulating iron, as indicated by transferrin saturation (TSAT), and increased body iron, as suggested by plasma ferritin concentrations.	Iron	59-63	transferrin	Homo sapiens	135-146
30623722-6	2019	In patients with systemic iron overload, increased urinary iron levels were associated with elevated circulating iron, as indicated by transferrin saturation (TSAT), and increased body iron, as suggested by plasma ferritin concentrations.	Iron	59-63	transferrin	Homo sapiens	135-146
30623722-6	2019	In patients with systemic iron overload, increased urinary iron levels were associated with elevated circulating iron, as indicated by transferrin saturation (TSAT), and increased body iron, as suggested by plasma ferritin concentrations.	Iron	59-63	transferrin	Homo sapiens	135-146
30623722-8	2019	In systemic iron overload, elevated urinary iron and transferrin levels were associated with increased injury to proximal tubules, indicated by increased urinary kidney injury marker 1 (KIM-1) excretion.	Iron	12-16	transferrin	Homo sapiens	53-64
30586625-8	2019	IRE-IRP interaction was affected due to conversion of IRP1 to cytosolic aconitase that was influenced by increased iron-sulfur scaffold protein iron-sulfur cluster assembly enzyme (ISCU) level.	Iron	115-119	iron-sulfur cluster assembly enzyme	Homo sapiens	181-185
30823916-1	2019	BACKGROUND: Iron is administered intravenously (IV) to many dialysis patients at regular intervals and iron stores are evaluated through periodic measurements of ferritin and transferrin saturation (TSAT).	Iron	12-16	transferrin	Homo sapiens	175-186
31221059-1	2019	Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include regulation of gene transcription, regulation of pre-mRNA processing, splicing, mRNA stability, translational silencing and enhancement, the control of iron turnover, and many others.	Iron	309-313	poly(rC) binding protein 1	Homo sapiens	72-79
30594846-1	2019	Treatment in IRIDA focuses on use of intravenous iron preparations to circumvent oral absorptive defect resulting from high levels of hepcidin due to TMPRSS6 gene variations.	Iron	49-53	transmembrane serine protease 6	Homo sapiens	150-157
30586625-8	2019	IRE-IRP interaction was affected due to conversion of IRP1 to cytosolic aconitase that was influenced by increased iron-sulfur scaffold protein iron-sulfur cluster assembly enzyme (ISCU) level.	Iron	144-148	iron-sulfur cluster assembly enzyme	Homo sapiens	181-185
30956962-8	2019	The mean serum ferritin and HbA2 levels were significantly lower, while the RDW, sickle Hb, and serum transferrin levels were significantly higher in patients with microcytosis and iron deficiency compared to non-iron deficient subjects (P&lt;0.05).	Iron	181-185	transferrin	Homo sapiens	102-113
30721440-0	2019	Removal efficiency of As(V) and Sb(III) in contaminated neutral drainage by Fe-loaded biochar.	Iron	76-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	22-27
30721440-6	2019	Based on these findings, Fe-loaded biochar by evaporation (E-product) seems promising for As(V) treatment in CND.	Iron	25-27	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
29594477-6	2019	Additionally, IP quercetin induced highly significant increased liver expression of hepcidin, a hormone known to inhibit intestinal iron uptake.	Iron	132-136	hepcidin antimicrobial peptide	Rattus norvegicus	84-92
30423260-11	2019	These findings demonstrate that PKCalpha promotes microvillus membrane DMT1 expression and intestinal iron uptake, contributing to diabetic iron loading.-Zhao, L., Bartnikas, T., Chu, X., Klein, J., Yun, C., Srinivasan, S., He, P. Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCalpha-dependent manner.	Iron	102-106	protein kinase C, alpha	Mus musculus	32-40
30423260-11	2019	These findings demonstrate that PKCalpha promotes microvillus membrane DMT1 expression and intestinal iron uptake, contributing to diabetic iron loading.-Zhao, L., Bartnikas, T., Chu, X., Klein, J., Yun, C., Srinivasan, S., He, P. Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCalpha-dependent manner.	Iron	140-144	protein kinase C, alpha	Mus musculus	32-40
30055235-3	2019	Each DMT1 isoform exhibits different expression patterns in cell-type specificity and distinct subcellular distribution, which enables cells to uptake both transferrin-bound and non-transferrin-bound irons efficiently.	Iron	200-205	transferrin	Homo sapiens	156-167
29969719-1	2019	In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells.	Iron	49-53	transferrin	Homo sapiens	16-27
29969719-1	2019	In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells.	Iron	49-53	transferrin	Homo sapiens	29-31
30055235-3	2019	Each DMT1 isoform exhibits different expression patterns in cell-type specificity and distinct subcellular distribution, which enables cells to uptake both transferrin-bound and non-transferrin-bound irons efficiently.	Iron	200-205	transferrin	Homo sapiens	182-193
29969719-2	2019	Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis.	Iron	9-13	transferrin	Homo sapiens	0-2
29969719-3	2019	TfR1 can mediate cellular uptake of both Tf and H-ferritin, an iron storage protein.	Iron	63-67	transferrin	Homo sapiens	0-2
30055235-8	2019	We summarize DMT1 expression depending on the types of cell or tissue and the function and mechanism of one of the iron chaperones, PCBP2.	Iron	115-119	poly(rC) binding protein 2	Homo sapiens	132-137
29969719-10	2019	Administration of apo-Tf, which scavenges free iron, has been explored for various clinical conditions including atransferrinemia, iron overload, and tissue ischemia.	Iron	47-51	transferrin	Homo sapiens	22-24
30218771-0	2019	Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase.	Iron	40-44	F-box and leucine rich repeat protein 5	Homo sapiens	77-85
30218771-0	2019	Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase.	Iron	23-27	F-box and leucine rich repeat protein 5	Homo sapiens	77-85
30218771-2	2019	In mammalian cells, iron regulatory protein 1 and 2 (IRP1 and IRP2) are the central regulators of cellular iron metabolism.	Iron	20-24	iron responsive element binding protein 2	Homo sapiens	62-66
30218771-4	2019	It is also well-known that the ubiquitin system plays central roles in cellular iron regulation because both IRPs having the IRE binding activity are recognized and ubiquitinated by the SCFFBXL5 ubiquitin ligase in condition of iron-replete.	Iron	80-84	F-box and leucine rich repeat protein 5	Homo sapiens	186-194
29969719-10	2019	Administration of apo-Tf, which scavenges free iron, has been explored for various clinical conditions including atransferrinemia, iron overload, and tissue ischemia.	Iron	131-135	transferrin	Homo sapiens	22-24
30513241-0	2019	50-Hz magnetic field impairs the expression of iron-related genes in the in vitro SOD1G93A model of amyotrophic lateral sclerosis.	Iron	47-51	superoxide dismutase 1	Homo sapiens	82-86
30553971-11	2019	Iron chelation in ccRCC cells but not benign renal cells suppressed HIF-1alpha and HIF-2alpha protein levels and transcriptional activity, and the degree and timing of HIF-2alpha suppression correlated with the onset of apoptosis.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	68-78
30844732-6	2019	Adding Prx2 to hemoglobin A altered the second shell of iron embedded in hemoglobin A.	Iron	56-60	peroxiredoxin 2	Homo sapiens	7-11
30218771-4	2019	It is also well-known that the ubiquitin system plays central roles in cellular iron regulation because both IRPs having the IRE binding activity are recognized and ubiquitinated by the SCFFBXL5 ubiquitin ligase in condition of iron-replete.	Iron	228-232	F-box and leucine rich repeat protein 5	Homo sapiens	186-194
30218771-5	2019	FBXL5, which is a substrate recognition subunit of SCFFBXL5, senses iron availability via its hemerythrin-like domain.	Iron	68-72	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
30218771-5	2019	FBXL5, which is a substrate recognition subunit of SCFFBXL5, senses iron availability via its hemerythrin-like domain.	Iron	68-72	F-box and leucine rich repeat protein 5	Homo sapiens	51-59
30218771-6	2019	In this small article, current understanding of the roles of SCFFBXL5-mediated degradation of IRPs played in cellular iron metabolism is discussed.	Iron	118-122	F-box and leucine rich repeat protein 5	Homo sapiens	61-69
30236787-8	2019	When physiologically relevant concentrations are used the window of redox opportunity ranges from +0.1 V to +0.9 V. The electrode potential for non-transferrin-bound iron in the form of iron citrate is close to 0 V and the reduction of iron(III) citrate by ascorbate is slow.	Iron	166-170	transferrin	Homo sapiens	148-159
30266679-2	2019	Proteins such as alpha-synuclein, tau and amyloid precursor protein that are pathologically associated with neurodegeneration are involved in molecular crosstalk with iron homeostatic proteins.	Iron	167-171	amyloid beta precursor protein	Homo sapiens	42-67
30316781-0	2019	Non-transferrin-bound iron transporters.	Iron	22-26	transferrin	Homo sapiens	4-15
30316781-1	2019	Most cells in the body acquire iron via receptor-mediated endocytosis of transferrin, the circulating iron transport protein.	Iron	31-35	transferrin	Homo sapiens	73-84
30316781-1	2019	Most cells in the body acquire iron via receptor-mediated endocytosis of transferrin, the circulating iron transport protein.	Iron	102-106	transferrin	Homo sapiens	73-84
30316781-2	2019	When cellular iron levels are sufficient, the uptake of transferrin decreases to limit further iron assimilation and prevent excessive iron accumulation.	Iron	14-18	transferrin	Homo sapiens	56-67
30316781-2	2019	When cellular iron levels are sufficient, the uptake of transferrin decreases to limit further iron assimilation and prevent excessive iron accumulation.	Iron	95-99	transferrin	Homo sapiens	56-67
30316781-2	2019	When cellular iron levels are sufficient, the uptake of transferrin decreases to limit further iron assimilation and prevent excessive iron accumulation.	Iron	95-99	transferrin	Homo sapiens	56-67
30316781-3	2019	In iron overload conditions, such as hereditary hemochromatosis and thalassemia major, unregulated iron entry into the plasma overwhelms the carrying capacity of transferrin, resulting in non-transferrin-bound iron (NTBI), a redox-active, potentially toxic form of iron.	Iron	3-7	transferrin	Homo sapiens	162-173
30316781-3	2019	In iron overload conditions, such as hereditary hemochromatosis and thalassemia major, unregulated iron entry into the plasma overwhelms the carrying capacity of transferrin, resulting in non-transferrin-bound iron (NTBI), a redox-active, potentially toxic form of iron.	Iron	99-103	transferrin	Homo sapiens	192-203
30316781-3	2019	In iron overload conditions, such as hereditary hemochromatosis and thalassemia major, unregulated iron entry into the plasma overwhelms the carrying capacity of transferrin, resulting in non-transferrin-bound iron (NTBI), a redox-active, potentially toxic form of iron.	Iron	99-103	transferrin	Homo sapiens	192-203
30316781-3	2019	In iron overload conditions, such as hereditary hemochromatosis and thalassemia major, unregulated iron entry into the plasma overwhelms the carrying capacity of transferrin, resulting in non-transferrin-bound iron (NTBI), a redox-active, potentially toxic form of iron.	Iron	99-103	transferrin	Homo sapiens	192-203
30316781-6	2019	A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6.	Iron	93-97	transferrin	Homo sapiens	75-86
30513241-4	2019	CONCLUSIONS: 50-Hz MF affects iron homeostasis in the in vitro SOD1G93A ALS model.	Iron	30-34	superoxide dismutase 1	Homo sapiens	63-67
29909454-11	2019	OGDR and iron reduced the cell viability and increased the expression of TLR-4 associated proteins (RIP3, MyD88, phospho-NF-kB, and release of IL-6) in BMVECs from diabetic animals.	Iron	9-13	toll-like receptor 4	Rattus norvegicus	73-78
30363006-1	2019	PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels.	Iron	84-88	interleukin 6	Homo sapiens	133-146
30363006-1	2019	PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels.	Iron	84-88	interleukin 6	Homo sapiens	148-152
30470799-7	2019	The target site for miR-346 overlaps with active sites for an iron-responsive element (IRE) and an interleukin-1 (IL-1) acute box element.	Iron	62-66	microRNA 346	Homo sapiens	20-27
30656553-6	2019	The transferrin receptors at the BBB, which are responsible for transporting transferrin-bound iron from the blood into the brain parenchyma, can be used to shuttle therapeutic molecules across the BBB.	Iron	95-99	transferrin	Homo sapiens	4-15
30656553-6	2019	The transferrin receptors at the BBB, which are responsible for transporting transferrin-bound iron from the blood into the brain parenchyma, can be used to shuttle therapeutic molecules across the BBB.	Iron	95-99	transferrin	Homo sapiens	77-88
29909454-11	2019	OGDR and iron reduced the cell viability and increased the expression of TLR-4 associated proteins (RIP3, MyD88, phospho-NF-kB, and release of IL-6) in BMVECs from diabetic animals.	Iron	9-13	interleukin 6	Rattus norvegicus	143-147
30609540-9	2019	Such determination revealed significant differences among lines with higher transferrin concentration in the line exhibiting higher iron levels, stressing the key aspects of this protein as importer of iron in cells.	Iron	132-136	transferrin	Homo sapiens	76-87
30899168-6	2019	Treatment of iron-overloaded rats with AGTE resulted in marked decreases in iron accumulation within liver, depletion in serum ferritin, and hepcidin levels.	Iron	13-17	hepcidin antimicrobial peptide	Rattus norvegicus	141-149
30899168-11	2019	Also, hepatic hepcidin was shown to be significantly correlated with oxidative and apoptotic relating biomarkers as well as an improvement in liver fibrosis of iron treated rats following AGTE treatment.	Iron	160-164	hepcidin antimicrobial peptide	Rattus norvegicus	14-22
30609540-9	2019	Such determination revealed significant differences among lines with higher transferrin concentration in the line exhibiting higher iron levels, stressing the key aspects of this protein as importer of iron in cells.	Iron	202-206	transferrin	Homo sapiens	76-87
30823541-0	2019	Targeting the Iron-Response Elements of the mRNAs for the Alzheimer"s Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity.	Iron	14-18	amyloid beta precursor protein	Homo sapiens	70-95
30873034-4	2019	In this study, we found that iron overload induced by 100 muM ferric ammonium citrate (FAC) caused apoptosis of BMSCs, promoted cleaved caspase-3 and BAX protein expressions while inhibited Bcl-2 protein expression, which effects were significantly attenuated by icariin treatment.	Iron	29-33	latexin	Homo sapiens	58-61
30790278-25	2019	AUTHORS" CONCLUSIONS: The included studies provide low certainty evidence that IV iron compared with oral iron increases haemoglobin, ferritin and transferrin levels in CKD participants, increases the number of participants who achieve target haemoglobin and reduces ESA requirements.	Iron	82-86	transferrin	Homo sapiens	147-158
30790278-25	2019	AUTHORS" CONCLUSIONS: The included studies provide low certainty evidence that IV iron compared with oral iron increases haemoglobin, ferritin and transferrin levels in CKD participants, increases the number of participants who achieve target haemoglobin and reduces ESA requirements.	Iron	106-110	transferrin	Homo sapiens	147-158
30676743-3	2019	Metyrapone and fluconazole are classic type II ligands that inhibit CYP3A4 with medium strength by ligating to the heme iron, whereas PMSF, lacking the heme-ligating moiety, acts as a weak type I ligand and inhibitor of CYP3A4.	Iron	120-124	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74
30760082-4	2019	Impaired iron status was defined as ferritin &lt;100 mug/L or transferrin saturation &lt;20%.	Iron	9-13	transferrin	Homo sapiens	62-73
30760082-6	2019	In multivariate models, greater norepinephrine levels were associated with impaired iron transport (transferrin saturation &lt;20%, odds ratio=2.28; 95% CI [1.19-4.35]; P=0.013), but not with impaired iron storage (ferritin &lt;100 mug/L, odds ratio=1.25; 95% CI [0.73-2.16]; P=0.415).	Iron	84-88	transferrin	Homo sapiens	100-111
30760082-7	2019	Norepinephrine was a significant predictor of increased iron demand (soluble transferrin receptor, standardized beta-coefficient=0.12; P=0.006) and low transferrin saturation (standardized beta-coefficient=-0.12; P=0.003).	Iron	56-60	transferrin	Homo sapiens	77-88
30873034-4	2019	In this study, we found that iron overload induced by 100 muM ferric ammonium citrate (FAC) caused apoptosis of BMSCs, promoted cleaved caspase-3 and BAX protein expressions while inhibited Bcl-2 protein expression, which effects were significantly attenuated by icariin treatment.	Iron	29-33	BCL2 associated X, apoptosis regulator	Homo sapiens	150-153
30873034-4	2019	In this study, we found that iron overload induced by 100 muM ferric ammonium citrate (FAC) caused apoptosis of BMSCs, promoted cleaved caspase-3 and BAX protein expressions while inhibited Bcl-2 protein expression, which effects were significantly attenuated by icariin treatment.	Iron	29-33	BCL2 apoptosis regulator	Homo sapiens	190-195
30873034-6	2019	Meanwhile, we found that iron overload induced by 100 muM FAC significantly inhibited mitochondrial fission protein FIS1 and fusion protein MFN2 expressions, inhibited DRP1 and Cytochrome C protein translocation from the cytoplasm to mitochondria.	Iron	25-29	latexin	Homo sapiens	54-57
30873034-6	2019	Meanwhile, we found that iron overload induced by 100 muM FAC significantly inhibited mitochondrial fission protein FIS1 and fusion protein MFN2 expressions, inhibited DRP1 and Cytochrome C protein translocation from the cytoplasm to mitochondria.	Iron	25-29	cytochrome c, somatic	Homo sapiens	177-189
30873034-9	2019	Further studies showed that icariin attenuated iron overload induced inactivation of the PI3K/AKT/mTOR pathway and activation of the ERK1/2 and JNK pathways.	Iron	47-51	AKT serine/threonine kinase 1	Homo sapiens	94-97
30873034-9	2019	Further studies showed that icariin attenuated iron overload induced inactivation of the PI3K/AKT/mTOR pathway and activation of the ERK1/2 and JNK pathways.	Iron	47-51	mechanistic target of rapamycin kinase	Homo sapiens	98-102
30873034-9	2019	Further studies showed that icariin attenuated iron overload induced inactivation of the PI3K/AKT/mTOR pathway and activation of the ERK1/2 and JNK pathways.	Iron	47-51	mitogen-activated protein kinase 8	Homo sapiens	144-147
30628436-4	2019	However, the number, chemical nature, and catalytic roles for the MftC [Fe-S] clusters remain unknown.	Iron	72-76	solute carrier family 25 member 32	Homo sapiens	66-70
30778158-9	2019	In addition, our results indicated that iron overload enhanced the release of interleukin-8 (IL-8), a chemokine that activates neutrophils, and subsequently elevated intracellular calcium concentration ([Ca2+]i).	Iron	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
30778158-9	2019	In addition, our results indicated that iron overload enhanced the release of interleukin-8 (IL-8), a chemokine that activates neutrophils, and subsequently elevated intracellular calcium concentration ([Ca2+]i).	Iron	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
30778158-11	2019	These findings suggest that the iron overload caused by engulfed MWCNTs results in the increase of IL-8 production and the elevation of [Ca2+]i, thereby activating the mitochondria-mediated apoptotic pathway.	Iron	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
30384050-0	2019	Adsorption behavior and mechanism of Mg/Fe layered double hydroxide with Fe3O4-carbon spheres on the removal of Pb(II) and Cu(II).	Iron	40-42	submaxillary gland androgen regulated protein 3B	Homo sapiens	112-129
30911357-0	2019	TMPRSS6 rs855791 polymorphism and susceptibility to iron deficiency anaemia in non-dialysis chronic kidney disease patients in South Africa.	Iron	52-56	transmembrane serine protease 6	Homo sapiens	0-7
30384050-1	2019	Mg/Fe layered double hydroxide loaded with Magnetic(Fe3O4) carbon spheres (MCs@Mg/Fe-LDHs) was firstly synthesized by a facile in-situ co-precipitation method to remove Pb(II) and Cu(II) pollution.	Iron	3-5	submaxillary gland androgen regulated protein 3B	Homo sapiens	169-186
30911357-1	2019	BACKGROUND: In genome-wide studies, there is a strong association between the TMPRSS6 allele A736V (rs855791) and significantly lower levels of serum iron, transferrin saturation, haemoglobin, and mean corpuscular volumes.	Iron	150-154	transmembrane serine protease 6	Homo sapiens	78-85
30384050-8	2019	Moreover, there existed competitive effect between Pb(II) and Cu(II) on the co-adsorption by MCs@Mg/Fe-LDHs.	Iron	100-102	submaxillary gland androgen regulated protein 3B	Homo sapiens	51-68
30384050-10	2019	Besides, in the real river water, the MCs@Mg/Fe-LDHs also exhibited stable adsorption capacity for Pb(II).	Iron	45-47	submaxillary gland androgen regulated protein 3B	Homo sapiens	99-105
30692261-8	2019	Administering DOX to mice induced cardiomyopathy with a rapid, systemic accumulation of nonheme iron via heme degradation by Nrf2-mediated up-regulation of Hmox1, which effect was abolished in Nrf2-deficent mice.	Iron	96-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
30809273-9	2019	Increased copper and iron contents, both of which were controlled by Mac1p in the NO-treated and MAC1-overexpressing cells, were not responsible for the increased biofilm formation.	Iron	21-25	Mac1p	Saccharomyces cerevisiae S288C	69-74
30692261-8	2019	Administering DOX to mice induced cardiomyopathy with a rapid, systemic accumulation of nonheme iron via heme degradation by Nrf2-mediated up-regulation of Hmox1, which effect was abolished in Nrf2-deficent mice.	Iron	96-100	heme oxygenase 1	Mus musculus	156-161
30692261-8	2019	Administering DOX to mice induced cardiomyopathy with a rapid, systemic accumulation of nonheme iron via heme degradation by Nrf2-mediated up-regulation of Hmox1, which effect was abolished in Nrf2-deficent mice.	Iron	96-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	193-197
30692261-9	2019	Conversely, zinc protoporphyrin IX, an Hmox1 antagonist, protected the DOX-treated mice, suggesting free iron released on heme degradation is necessary and sufficient to induce cardiac injury.	Iron	105-109	heme oxygenase 1	Mus musculus	39-44
32257088-6	2019	After 5 days of Fe deficiency, the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione reductase and ascorbate peroxidase) were significantly higher than in plants supplied with Fe in the absence or presence of Cd.	Iron	16-18	catalase	Homo sapiens	92-100
30742009-5	2019	The nuclear/mitotic spindle associated protein Ccdc117 interacts with the MIP18/MMS19 cytoplasmic iron-sulfur (FeS) cluster assembly (CIA) complex, which transfers critical FeS clusters to several key enzymes with functions in DNA repair and replication.	Iron	111-114	coiled-coil domain containing 117	Mus musculus	47-54
30742009-5	2019	The nuclear/mitotic spindle associated protein Ccdc117 interacts with the MIP18/MMS19 cytoplasmic iron-sulfur (FeS) cluster assembly (CIA) complex, which transfers critical FeS clusters to several key enzymes with functions in DNA repair and replication.	Iron	173-176	coiled-coil domain containing 117	Mus musculus	47-54
30804745-5	2019	We computed also the Cp:Tf ratio as an index of oxidative stress related to iron metabolism.	Iron	76-80	transferrin	Homo sapiens	24-26
30478858-0	2019	Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice.	Iron	0-4	bone morphogenetic protein 2	Mus musculus	60-64
30728365-1	2019	Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells.	Iron	96-100	transferrin	Homo sapiens	78-89
30395253-7	2019	In the atg5-1 mutant, which is completely defective in autophagy, the efficiency of Fe translocation from vegetative organs to seeds was severely decreased even when Fe was provided during seed formation.	Iron	84-86	autophagy protein Apg5 family	Arabidopsis thaliana	7-11
30395253-7	2019	In the atg5-1 mutant, which is completely defective in autophagy, the efficiency of Fe translocation from vegetative organs to seeds was severely decreased even when Fe was provided during seed formation.	Iron	166-168	autophagy protein Apg5 family	Arabidopsis thaliana	7-11
30395253-8	2019	Combining atg5-1 with the sid2 mutation that counteracts premature senescence associated with autophagy deficiency and using 57Fe pulse labeling, we propose a two-step mechanism in which Fe taken up de novo during seed formation is first accumulated in vegetative organs and subsequently remobilized to seeds.	Iron	127-129	autophagy protein Apg5 family	Arabidopsis thaliana	10-14
30720714-1	2019	We have synthesized single crystals of iron-based superconducting Ca10(Pt4As8)((Fe0.86Pt0.14)2As2)5 and performed extensive measurements on their transport properties.	Iron	39-43	carbonic anhydrase 10	Homo sapiens	66-70
30717475-2	2019	Our aim was to assess serum non-transferrin bound iron (NTBI), a toxic biochemical that accumulates in blood when too much iron is absorbed, in Cambodian women who received daily iron supplements in accordance with the 2016 global World Health Organization (WHO) guidelines.	Iron	50-54	transferrin	Homo sapiens	32-43
30728365-8	2019	We hypothesize that decreased expression of miR-148a in HCC may elevate transferrin-bound iron uptake, increasing cellular iron levels and cell proliferation.	Iron	90-94	transferrin	Homo sapiens	72-83
30478858-9	2019	Thus, BMP2 has at least a partially redundant role in hepcidin regulation by serum iron, tissue iron, inflammation and erythropoietic drive.	Iron	83-87	bone morphogenetic protein 2	Mus musculus	6-10
30478858-9	2019	Thus, BMP2 has at least a partially redundant role in hepcidin regulation by serum iron, tissue iron, inflammation and erythropoietic drive.	Iron	96-100	bone morphogenetic protein 2	Mus musculus	6-10
30277817-7	2019	Direct addition of iron to purified DNMT in vitro decreased enzyme activity in a concentration-dependent manner.	Iron	19-23	DNA methyltransferase (cytosine-5) 1	Mus musculus	36-40
30136122-0	2019	The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer"s disease.	Iron	125-129	apolipoprotein E	Homo sapiens	31-35
30155753-13	2019	Concurrently, the mean concentrations of Fe and Mn in tube well and channel water are exceeded Cambodian aesthetic guideline of 300 microg L-1 and 100 microg L-1, respectively.	Iron	41-43	immunoglobulin kappa variable 1-16	Homo sapiens	139-161
30502392-7	2019	CONCLUSION: The reduction of AtGRXS16, which is mandatory for its oxidoreductase activity and the binding of Fe-S clusters, depends on light through the plastidial FTR/TRX system.	Iron	109-113	CAX-interacting protein 2	Arabidopsis thaliana	29-37
30528492-2	2019	Haptoglobin (Hp) is an acute phase reactant that scavenges extracorpuscular hemoglobin from circulation and prevents heme-iron oxidative damage.	Iron	122-126	haptoglobin	Homo sapiens	0-11
29981852-3	2019	Previously, WDR45 de novo mutations were reported in certain adult and pediatric patients due to iron accumulation.	Iron	97-101	WD repeat domain 45	Homo sapiens	12-17
30207798-0	2019	Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.	Iron	0-4	insulin	Homo sapiens	104-111
30133149-5	2019	In this review, we will discuss the role of p53 tumor suppressor in iron homeostasis.	Iron	68-72	tumor protein p53	Homo sapiens	44-47
30557609-6	2019	Over expression of ISCU (Iron-sulfur cluster assembly enzyme, a mitochondrial protein) significantly attenuated DHA induced ferroptosis by regulating iron metabolism, rescuing the mitochondrial function and increasing the level of GSH.	Iron	25-29	iron-sulfur cluster assembly enzyme	Homo sapiens	19-23
30557609-6	2019	Over expression of ISCU (Iron-sulfur cluster assembly enzyme, a mitochondrial protein) significantly attenuated DHA induced ferroptosis by regulating iron metabolism, rescuing the mitochondrial function and increasing the level of GSH.	Iron	150-154	iron-sulfur cluster assembly enzyme	Homo sapiens	19-23
30207798-8	2019	Knockdown of tfR1 and iron-responsive element-binding proteins 2 prevented PA-induced iron uptake and insulin resistance.	Iron	22-26	insulin	Homo sapiens	102-109
30207798-2	2019	The association between iron disturbances and insulin resistance has recently begun to receive a lot of attention.	Iron	24-28	insulin	Homo sapiens	46-53
30207798-10	2019	Iron overload may play a critical role in PA-induced insulin resistance.	Iron	0-4	insulin	Homo sapiens	53-60
30207798-11	2019	Blocking iron overload may thus be a useful strategy for preventing insulin resistance and diabetes.-Cui, R., Choi, S.-E., Kim, T. H., Lee, H. J., Lee, S. J., Kang, Y., Jeon, J. Y., Kim, H. J., Lee, K.-W. Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.	Iron	9-13	insulin	Homo sapiens	68-75
30207798-4	2019	We investigated the molecular mechanism underlying iron dysregulation in PA-induced insulin resistance.	Iron	51-55	insulin	Homo sapiens	84-91
30207798-11	2019	Blocking iron overload may thus be a useful strategy for preventing insulin resistance and diabetes.-Cui, R., Choi, S.-E., Kim, T. H., Lee, H. J., Lee, S. J., Kang, Y., Jeon, J. Y., Kim, H. J., Lee, K.-W. Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.	Iron	9-13	insulin	Homo sapiens	309-316
30207798-6	2019	The iron chelator deferoxamine dramatically inhibited PA-induced insulin resistance, and iron donors impaired insulin sensitivity by activating JNK.	Iron	4-8	insulin	Homo sapiens	65-72
30207798-6	2019	The iron chelator deferoxamine dramatically inhibited PA-induced insulin resistance, and iron donors impaired insulin sensitivity by activating JNK.	Iron	89-93	mitogen-activated protein kinase 8	Homo sapiens	144-147
30489504-2	2019	This study tested the hypothesis that elevated inflammatory cytokines and decreased EPO would be associated with iron-restricted anemia while accounting for operative blood loss, phlebotomy blood loss, and red blood cell (RBC) transfusion volume.	Iron	113-117	erythropoietin	Homo sapiens	84-87
30575389-0	2019	Iron-Catalyzed C(sp2)-C(sp3) Cross-Coupling of Chlorobenzenesulfonamides with Alkyl Grignard Reagents: Entry to Alkylated Aromatics.	Iron	0-4	Sp2 transcription factor	Homo sapiens	15-20
30575389-2	2019	We report the iron-catalyzed C(sp2)-C(sp3) cross-coupling of chlorobenzosulfonamides with alkyl Grignard reagents under mild and sustainable conditions.	Iron	14-18	Sp2 transcription factor	Homo sapiens	29-34
30692693-6	2019	Measures of retention and bioaccessibility of iron and zinc in processed transgenic cassava indicated that IRT1 + FER1 plants could provide 40-50% of the EAR for iron and 60-70% of the EAR for zinc in 1- to 6-year-old children and nonlactating, nonpregnant West African women.	Iron	46-50	ferretin 1	Arabidopsis thaliana	114-118
30312834-0	2019	Association of SNPs in transferrin and transferrin receptor genes with blood iron levels in human.	Iron	77-81	transferrin	Homo sapiens	23-34
30312834-0	2019	Association of SNPs in transferrin and transferrin receptor genes with blood iron levels in human.	Iron	77-81	transferrin	Homo sapiens	39-50
30312834-1	2019	Iron is bound to mobile transferrin (TF) and ferritin in blood.	Iron	0-4	transferrin	Homo sapiens	24-35
30312834-1	2019	Iron is bound to mobile transferrin (TF) and ferritin in blood.	Iron	0-4	transferrin	Homo sapiens	37-39
30312834-2	2019	TF receptors (TFRC and TFR2) regulate intracellular iron by delivering iron from TF into the cytoplasm.	Iron	52-56	transferrin	Homo sapiens	0-2
30312834-2	2019	TF receptors (TFRC and TFR2) regulate intracellular iron by delivering iron from TF into the cytoplasm.	Iron	71-75	transferrin	Homo sapiens	0-2
30312834-3	2019	In this study, we examined the effects of 10 single nucleotide polymorphisms (SNPs) in each of the genes for TF and TF receptors on blood iron concentrations in Japanese subjects.	Iron	138-142	transferrin	Homo sapiens	109-111
30312834-3	2019	In this study, we examined the effects of 10 single nucleotide polymorphisms (SNPs) in each of the genes for TF and TF receptors on blood iron concentrations in Japanese subjects.	Iron	138-142	transferrin	Homo sapiens	116-118
30312834-8	2019	Among the 10 SNPs in TF, TFRC, and TFR2 genes, significant associations were observed between TF genotypes (rs12769) and male iron concentrations.	Iron	126-130	transferrin	Homo sapiens	21-23
30312834-8	2019	Among the 10 SNPs in TF, TFRC, and TFR2 genes, significant associations were observed between TF genotypes (rs12769) and male iron concentrations.	Iron	126-130	transferrin	Homo sapiens	25-27
30692693-6	2019	Measures of retention and bioaccessibility of iron and zinc in processed transgenic cassava indicated that IRT1 + FER1 plants could provide 40-50% of the EAR for iron and 60-70% of the EAR for zinc in 1- to 6-year-old children and nonlactating, nonpregnant West African women.	Iron	162-166	ferretin 1	Arabidopsis thaliana	114-118
29679389-2	2019	Natural resistance-associated macrophage protein-1 (Nramp1) was previously shown to contribute to the degradation of extracellular alpha-synuclein in microglia under conditions of iron overload.	Iron	180-184	solute carrier family 11 member 1	Homo sapiens	0-50
29679389-2	2019	Natural resistance-associated macrophage protein-1 (Nramp1) was previously shown to contribute to the degradation of extracellular alpha-synuclein in microglia under conditions of iron overload.	Iron	180-184	solute carrier family 11 member 1	Homo sapiens	52-58
30723395-4	2019	The process of misfolding and aggregation of neuronal proteins such as alpha-synuclein, Tau, amyloid beta (Abeta), TDP-43 or SOD1 is a common hallmark of many neurodegenerative disorders and iron has been shown to facilitate protein aggregation.	Iron	191-195	TAR DNA binding protein	Homo sapiens	115-121
30782036-4	2019	Iron deficiency anemia was established when ferritin <30microg/l and transferrin saturation <16%.	Iron	0-4	transferrin	Homo sapiens	69-80
30782036-5	2019	Iron deficiency anemia and anemia of chronic disease were established when ferritin was between 30 and 100microg/l and transferrin saturation <16%.	Iron	0-4	transferrin	Homo sapiens	119-130
30693516-0	2019	Iron overload threatens the growth of osteoblast cells via inhibiting the PI3K/AKT/FOXO3a/DUSP14 signaling pathway.	Iron	0-4	thymoma viral proto-oncogene 1	Mus musculus	79-82
30693516-10	2019	Most importantly, our analysis demonstrated the essential role of the PI3K/AKT/FOXO3a/DUSP14 signaling pathway in the defense against iron overload in osteoblast cells.	Iron	134-138	thymoma viral proto-oncogene 1	Mus musculus	75-78
30696910-5	2019	Spatial profiling of TAM iron deposit infiltration defined regions of maximal accumulation and response to the CSF1R inhibitor, and revealed differences between microenvironments of human cancer according to levels of polarized macrophage iron accumulation in stromal margins.	Iron	25-29	Myeloproliferative syndrome, transient (transient abnormal myelopoiesis)	Homo sapiens	21-24
30696910-6	2019	We therefore demonstrate that iron deposition serves as an endogenous metabolic imaging biomarker of TAM infiltration in breast cancer that has high translational potential for evaluation of immunotherapeutic response.	Iron	30-34	Myeloproliferative syndrome, transient (transient abnormal myelopoiesis)	Homo sapiens	101-104
30679587-0	2019	The bacterial MrpORP is a novel Mrp/NBP35 protein involved in iron-sulfur biogenesis.	Iron	62-66	ATP binding cassette subfamily C member 1	Homo sapiens	14-17
30679587-3	2019	Mrp/NBP35 ATP-binding proteins are a subclass of the soluble P-loop containing nucleoside triphosphate hydrolase superfamily (P-loop NTPase) known to bind and transfer Fe-S clusters in vitro.	Iron	168-172	ATP binding cassette subfamily C member 1	Homo sapiens	0-3
30576925-6	2019	The addition of AUR to L-ASC-treated cells triggers the accumulation of H2O2 in the cells, which results in iron-dependent cytotoxicity.	Iron	108-112	PYD and CARD domain containing	Homo sapiens	25-28
30173950-5	2019	Iron excess develops following hypersideremia and the formation of non-transferrin-bound iron, which targets preferentially parenchymal cells (hepatocytes).	Iron	0-4	transferrin	Homo sapiens	71-82
30173950-5	2019	Iron excess develops following hypersideremia and the formation of non-transferrin-bound iron, which targets preferentially parenchymal cells (hepatocytes).	Iron	89-93	transferrin	Homo sapiens	71-82
30760976-0	2019	Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells.	Iron	27-31	iron responsive element binding protein 2	Homo sapiens	51-55
30760976-0	2019	Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells.	Iron	27-31	F-box and leucine rich repeat protein 5	Homo sapiens	64-69
30760976-1	2019	Iron regulatory protein 2 (IRP2) plays a key role in the cellular iron homeostasis and could be regulated by a variety of factors, such as oxidative stress, hypoxia and iron, etc.	Iron	66-70	iron responsive element binding protein 2	Homo sapiens	0-25
30760976-1	2019	Iron regulatory protein 2 (IRP2) plays a key role in the cellular iron homeostasis and could be regulated by a variety of factors, such as oxidative stress, hypoxia and iron, etc.	Iron	66-70	iron responsive element binding protein 2	Homo sapiens	27-31
30760976-1	2019	Iron regulatory protein 2 (IRP2) plays a key role in the cellular iron homeostasis and could be regulated by a variety of factors, such as oxidative stress, hypoxia and iron, etc.	Iron	169-173	iron responsive element binding protein 2	Homo sapiens	0-25
30760976-1	2019	Iron regulatory protein 2 (IRP2) plays a key role in the cellular iron homeostasis and could be regulated by a variety of factors, such as oxidative stress, hypoxia and iron, etc.	Iron	169-173	iron responsive element binding protein 2	Homo sapiens	27-31
30760976-2	2019	IRP2 depletion results in neurodegenerative movement disorder with the loss of neurons and accumulations of iron.	Iron	108-112	iron responsive element binding protein 2	Homo sapiens	0-4
30760976-3	2019	Since oxidative stress extensively exists in several neurodegenerative diseases where iron accumulation also exists, it is important to clarify the mechanisms underlying the effects of oxidative stress on IRP2 expression and its consequence.	Iron	86-90	iron responsive element binding protein 2	Homo sapiens	205-209
30760976-7	2019	The protein levels of IRP2, but not for its mRNA levels, were observed decreased in both groups, which resulted in the lower TfR1 expression and decreased iron uptake in these cells.	Iron	155-159	iron responsive element binding protein 2	Homo sapiens	22-26
30234208-1	2019	The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-beta (Abeta) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer"s disease (AD).	Iron	53-55	amyloid beta precursor protein	Homo sapiens	74-86
30234208-1	2019	The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-beta (Abeta) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer"s disease (AD).	Iron	53-55	amyloid beta precursor protein	Homo sapiens	88-93
30723395-4	2019	The process of misfolding and aggregation of neuronal proteins such as alpha-synuclein, Tau, amyloid beta (Abeta), TDP-43 or SOD1 is a common hallmark of many neurodegenerative disorders and iron has been shown to facilitate protein aggregation.	Iron	191-195	superoxide dismutase 1	Homo sapiens	125-129
30449675-0	2019	Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2.	Iron	16-20	iron responsive element binding protein 2	Homo sapiens	67-92
30449675-3	2019	Cisplatin causes intracellular iron deficiency through direct inhibition of the master regulator of iron metabolism, iron regulatory protein 2 (IRP2) with marginal effects on IRP1.	Iron	31-35	iron responsive element binding protein 2	Homo sapiens	117-142
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	123-125	TEF transcription factor, PAR bZIP family member	Homo sapiens	21-24
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	123-125	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	123-125	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	123-125	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	123-125	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	176-178	TEF transcription factor, PAR bZIP family member	Homo sapiens	21-24
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	176-178	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	176-178	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	176-178	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30449675-3	2019	Cisplatin causes intracellular iron deficiency through direct inhibition of the master regulator of iron metabolism, iron regulatory protein 2 (IRP2) with marginal effects on IRP1.	Iron	31-35	iron responsive element binding protein 2	Homo sapiens	144-148
30658411-5	2019	Its reaction with Ag[TEF] and Cu[TEF] ([TEF]- = [Al{OC(CF3)3}4]-) leads to the selective formation of the complexes [Ag{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (4) and [Cu{Cp*Fe(micro,eta5:eta5-P5)Mo(CO)3}2][TEF] (5), respectively.	Iron	176-178	TEF transcription factor, PAR bZIP family member	Homo sapiens	33-36
30449675-4	2019	Cisplatin, but not carboplatin or transplatin, binds human IRP2 at Cys512 and Cys516 and impairs IRP2 binding to iron-responsive elements of ferritin and transferrin receptor-1 (TfR1) mRNAs.	Iron	113-117	iron responsive element binding protein 2	Homo sapiens	97-101
30561197-6	2019	The method is linear for iron concentrations in the range of 0.10-6.00 mg L-1 and offers good precision (CV 0.4-10.1%) and low limits of detection (0.02 mg L-1) and quantification (0.06 mg L-1).	Iron	25-29	immunoglobulin kappa variable 1-16	Homo sapiens	74-77
30561197-6	2019	The method is linear for iron concentrations in the range of 0.10-6.00 mg L-1 and offers good precision (CV 0.4-10.1%) and low limits of detection (0.02 mg L-1) and quantification (0.06 mg L-1).	Iron	25-29	immunoglobulin kappa variable 1-16	Homo sapiens	156-159
30561197-6	2019	The method is linear for iron concentrations in the range of 0.10-6.00 mg L-1 and offers good precision (CV 0.4-10.1%) and low limits of detection (0.02 mg L-1) and quantification (0.06 mg L-1).	Iron	25-29	immunoglobulin kappa variable 1-16	Homo sapiens	156-159
30650364-2	2019	Mammalian serum transferrin (TF) plays a primary role in delivering iron to cells.	Iron	68-72	transferrin	Homo sapiens	16-27
30650364-2	2019	Mammalian serum transferrin (TF) plays a primary role in delivering iron to cells.	Iron	68-72	transferrin	Homo sapiens	29-31
30395929-5	2019	Heterozygote IL-1beta T-carriers demonstrated poorer switching performance in relation to striatal iron content as compared to IL-1beta C/C counterparts, despite the two groups being of similar age.	Iron	99-103	interleukin 1 beta	Homo sapiens	13-21
30697143-0	2018	The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls.	Iron	50-54	superoxide dismutase 1	Homo sapiens	105-108
30697143-3	2018	Iron accumulation has been observed in both sporadic and familial forms of ALS, including mouse models.	Iron	0-4	superoxide dismutase 1	Homo sapiens	75-78
30697143-4	2018	Therefore, the dysregulation of iron metabolism could play a role in the pathological oxidative stress in ALS.	Iron	32-36	superoxide dismutase 1	Homo sapiens	106-109
30697143-6	2018	Reports of accumulation of iron, high serum ferritin, and low serum transferrin levels in ALS patients have encouraged researchers to consider dysregulated iron metabolism as an integral part of ALS pathophysiology.	Iron	156-160	superoxide dismutase 1	Homo sapiens	195-198
30697143-9	2018	Furthermore, the iron regulatory pathways, particularly involving hepcidin, have not been thoroughly explored yet within the pathogenesis of iron overload in ALS.	Iron	141-145	superoxide dismutase 1	Homo sapiens	158-161
30697143-10	2018	In this sense, it is also essential to explore the relation between iron overload and other ALS-related events, such as neuro-inflammation, protein aggregation, and iron-driven cell death, termed ferroptosis.	Iron	68-72	superoxide dismutase 1	Homo sapiens	92-95
30697143-11	2018	In this review, we point out limits of the designs of certain studies that may prevent the understanding of the role of iron in ALS and discuss the relevance of the published data regarding the pathogenic impact of iron metabolism deregulation in this disease and the therapeutics targeting this pathway.	Iron	120-124	superoxide dismutase 1	Homo sapiens	128-131
30014470-4	2019	The beneficial cardiovascular biomarkers caveolin-1 and adiponectin were higher in both control and anemic rats fed fermented goat milk either with normal Fe or Fe overload with respect to fermented cow milk.	Iron	161-163	caveolin 1	Rattus norvegicus	41-51
30395929-6	2019	With increasing genetic inflammation risk, homozygote IL-1beta T/T carriers had lesser age-related variance in striatal iron content as compared to the other groups but showed a similar association of greater striatal iron content predicting poorer cognitive switching.	Iron	120-124	interleukin 1 beta	Homo sapiens	54-62
30395929-6	2019	With increasing genetic inflammation risk, homozygote IL-1beta T/T carriers had lesser age-related variance in striatal iron content as compared to the other groups but showed a similar association of greater striatal iron content predicting poorer cognitive switching.	Iron	218-222	interleukin 1 beta	Homo sapiens	54-62
30881609-7	2019	Specifically, we show that ACPM interacts with endogenous Fe-S cluster complex components through binding of the LYRM protein ISD11/LYRM4.	Iron	58-62	LYR motif containing 4	Homo sapiens	126-131
30662950-6	2019	Since toxic iron accumulates in RD, we propose TF supplementation as an adjunctive therapy to surgery for improving the visual outcomes of patients with RD.	Iron	12-16	transferrin	Homo sapiens	47-49
30881663-2	2019	Peroxidase catalysis requires a vacant Fe coordination site, i.e., cyt c must undergo an activation process involving structural changes that rupture the native Met80-Fe contact.	Iron	39-41	cytochrome c, somatic	Homo sapiens	67-72
30628289-6	2019	The coagulation performance is better than that of the conventional coagulants polysilicate iron (PSF), Al2(SO4)3, and FeCl3.	Iron	92-96	insulin like growth factor binding protein 7	Homo sapiens	98-101
30881663-2	2019	Peroxidase catalysis requires a vacant Fe coordination site, i.e., cyt c must undergo an activation process involving structural changes that rupture the native Met80-Fe contact.	Iron	167-169	cytochrome c, somatic	Homo sapiens	67-72
30881609-7	2019	Specifically, we show that ACPM interacts with endogenous Fe-S cluster complex components through binding of the LYRM protein ISD11/LYRM4.	Iron	58-62	LYR motif containing 4	Homo sapiens	132-137
30970349-8	2019	When iron deficiency (defined as ferritin &lt;100 ng/mL or serum ferritin 100-299 ng/mL and transferrin saturation &lt;20%) is present, current evidence supports treating HF patients with iron deficiency with IV iron.	Iron	5-9	transferrin	Homo sapiens	92-103
30609006-27	2019	Iron did not improve sleepiness compared to placebo, as measured on the Epworth Sleepiness Scale (data not provided, 1 study, 60 participants) but did improve the daytime tiredness item of the RLS-6 compared to placebo (least squares mean difference -1.5, 95% CI -2.5 to -0.6; 1 study, 110 participants).	Iron	0-4	RLS6	Homo sapiens	193-198
30176414-0	2019	Performance of Pb(II) removal by an activated carbon supported nanoscale zero-valent iron composite at ultralow iron content.	Iron	85-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	15-21
30176414-0	2019	Performance of Pb(II) removal by an activated carbon supported nanoscale zero-valent iron composite at ultralow iron content.	Iron	112-116	submaxillary gland androgen regulated protein 3B	Homo sapiens	15-21
30176414-1	2019	Activated carbon supported nanoscale zero-valent iron composite (NZVI/AC) at ultralow iron content was synthesized and used to remove Pb(II) from aqueous solution.	Iron	49-53	submaxillary gland androgen regulated protein 3B	Homo sapiens	134-140
30176414-3	2019	The NZVI/AC with the iron content of only 1.57% showed a highly efficient Pb(II) removal performance with 95% of Pb(II) eliminated within 5 min.	Iron	21-25	submaxillary gland androgen regulated protein 3B	Homo sapiens	74-80
30176414-3	2019	The NZVI/AC with the iron content of only 1.57% showed a highly efficient Pb(II) removal performance with 95% of Pb(II) eliminated within 5 min.	Iron	21-25	submaxillary gland androgen regulated protein 3B	Homo sapiens	113-119
30176414-9	2019	To summarize, these results represent the first fabrication of NZVI/AC composites with such low iron loading that still present an outstanding Pb(II) removal performance in drinking water purification.	Iron	96-100	submaxillary gland androgen regulated protein 3B	Homo sapiens	143-149
29874928-9	2019	The FE-Mg was increased in 23% of patients with ADPKD/ARPKD (all had chronic kidney disease stages 2-4) and in 63% of patients with RCAD, where it significantly correlated with estimated glomerular filtration rate (r = -0.87, P < 0.01).	Iron	4-6	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	54-59
31456203-5	2019	Plasma transferrin (Tf) then carries iron to various tissues and cells.	Iron	37-41	transferrin	Homo sapiens	7-18
31456203-5	2019	Plasma transferrin (Tf) then carries iron to various tissues and cells.	Iron	37-41	transferrin	Homo sapiens	20-22
31228369-1	2019	Age-related neurodegenerative diseases, including Parkinson"s disease, are characterized by a number of pathomorphological signs, such as neuron loss in certain brain structures, gliosis, iron accumulation.	Iron	188-192	renin binding protein	Homo sapiens	0-3
31456206-4	2019	Iron metabolism mainly depends on iron regulatory proteins including ferritin, transferrin and transferrin receptor, hepcidin, ferroportin, lactoferrin.	Iron	0-4	transferrin	Homo sapiens	79-90
30136029-11	2019	Our findings suggest that carnosine may modulate iron metabolism in high-risk groups which could ameliorate insulin resistance and prevent type 2 diabetes.	Iron	49-53	insulin	Homo sapiens	108-115
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	82-86	solute carrier family 25, member 37	Mus musculus	104-112
31826380-0	2019	Associations between iron status and insulin resistance in Chinese children and adolescents: findings from the China Health and Nutrition Survey.	Iron	21-25	insulin	Homo sapiens	37-44
31826380-1	2019	BACKGROUND AND OBJECTIVES: Iron homeostasis abnormalities are associated with insulin resistance (IR), but studies on such associations in children and adolescents are limited and have contrasting results.	Iron	27-31	insulin	Homo sapiens	78-85
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	82-86	solute carrier family 25, member 28	Mus musculus	117-125
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	191-195	solute carrier family 25, member 37	Mus musculus	104-112
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	191-195	solute carrier family 25, member 28	Mus musculus	117-125
30482256-7	2019	Hepatic expression of the Cu chaperones antioxidant 1 Cu chaperone (P=0 042) and cytochrome c oxidase Cu chaperone (COX17, P=0 020) decreased in the Fe-deficient dams, while the expression of the genes of Zn metabolism was unaltered.	Iron	149-151	cytochrome c oxidase copper chaperone COX17	Rattus norvegicus	116-121
31311016-1	2019	BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.	Iron	74-78	transferrin	Homo sapiens	12-23
31311016-1	2019	BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.	Iron	74-78	transferrin	Homo sapiens	99-110
31311016-1	2019	BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.	Iron	152-156	transferrin	Homo sapiens	12-23
31311016-1	2019	BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.	Iron	152-156	transferrin	Homo sapiens	99-110
31311016-1	2019	BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.	Iron	152-156	transferrin	Homo sapiens	12-23
31311016-1	2019	BACKGROUND: Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.	Iron	152-156	transferrin	Homo sapiens	99-110
30897319-0	2019	Moonlighting Protein Glyceraldehyde-3-Phosphate Dehydrogenase: A Cellular Rapid-Response Molecule for Maintenance of Iron Homeostasis in Hypoxia.	Iron	117-121	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	21-61
29666474-2	2019	The human iron-sulfur binding protein NAF-1/CISD2 binds to Bcl-2 and its disruption in cells leads to an increase in apoptosis.	Iron	10-14	BCL2 apoptosis regulator	Homo sapiens	59-64
30704983-11	2019	Hypoxia reduced iron deprivation-associated TNF and IL1beta expression in HT-29 cells through the induction of autophagy.	Iron	16-20	tumor necrosis factor	Homo sapiens	44-47
30704983-11	2019	Hypoxia reduced iron deprivation-associated TNF and IL1beta expression in HT-29 cells through the induction of autophagy.	Iron	16-20	interleukin 1 beta	Homo sapiens	52-59
30704983-13	2019	Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta.	Iron	0-4	tumor necrosis factor	Homo sapiens	74-77
30704983-13	2019	Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	82-89
30704983-13	2019	Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta.	Iron	0-4	tumor necrosis factor	Homo sapiens	164-167
30704983-13	2019	Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	172-179
30897319-9	2019	CONCLUSION: Our results suggest the role of GAPDH-mediated Tf uptake as a rapid response mechanism by which cells acquire iron during the early stages of hypoxia.	Iron	122-126	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	44-49
30897319-2	2019	The mobilization of iron stores from macrophage to plasma as holo-transferrin (Tf) from where it is accessible to erythroid precursor cells impacts iron homeostasis.	Iron	20-24	transferrin	Homo sapiens	66-77
30897319-2	2019	The mobilization of iron stores from macrophage to plasma as holo-transferrin (Tf) from where it is accessible to erythroid precursor cells impacts iron homeostasis.	Iron	148-152	transferrin	Homo sapiens	66-77
30897319-3	2019	Despite the immediate need for enhanced iron uptake by bone marrow cells, numerous studies have shown that transferrin receptor levels do not rise until more than 24 hours after the onset of hypoxia, suggesting the existence of heretofore unknown rapid response cellular machinery for iron acquisition in the early stages of cellular hypoxia.	Iron	285-289	transferrin	Homo sapiens	107-118
30897319-6	2019	RESULTS: In the current study, we demonstrated that hypoxia induces K562 cells to translocate the cytosolic moonlighting protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) onto cell surfaces and into the extracellular milieu to acquire transferrin-bound iron, even while levels of the classical transferrin receptor TfR1 (CD71) remain suppressed.	Iron	260-264	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	129-169
30897319-6	2019	RESULTS: In the current study, we demonstrated that hypoxia induces K562 cells to translocate the cytosolic moonlighting protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) onto cell surfaces and into the extracellular milieu to acquire transferrin-bound iron, even while levels of the classical transferrin receptor TfR1 (CD71) remain suppressed.	Iron	260-264	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	171-176
30991411-7	2019	PHD inhibitors stabilize the transcription factor HIF, increasing the expression of downstream target genes, including EPO and enzymes involved in iron metabolism, resulting in increased EPO production and improved iron utilization.	Iron	147-151	erythropoietin	Homo sapiens	187-190
31187872-12	2019	Hyaluronic acid serum level was positively and iron concentration was negatively associated with TGF-b1 ex-pression in the selected consecutive liver compartments.	Iron	47-51	transforming growth factor beta 1	Homo sapiens	97-103
30763826-10	2019	However, in the patients with myocardial iron deposition, there were trends toward higher pretransplant transferrin saturation (TSAT) and more units of red blood cells transfused (uRBC).	Iron	41-45	transferrin	Homo sapiens	104-115
30448512-4	2019	Knowing that the Abeta42 peptide precipitates iron by binding iron ions at amino acid residues D1, E3, H11, H13, and H14, we synthesized a 5-repeat (HAYED) sequence peptide.	Iron	46-50	skull morphology 4	Mus musculus	99-106
31165467-10	2019	CONCLUSIONS: EPO administered with the oral dose of iron in pregnant women with anemia caused by iron deficiency shows higher effectiveness than the use of iron preparations parenterally.	Iron	52-56	erythropoietin	Homo sapiens	13-16
31165467-10	2019	CONCLUSIONS: EPO administered with the oral dose of iron in pregnant women with anemia caused by iron deficiency shows higher effectiveness than the use of iron preparations parenterally.	Iron	97-101	erythropoietin	Homo sapiens	13-16
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	5-9	Isa2p	Saccharomyces cerevisiae S288C	52-57
30745811-6	2019	Those with iron overload had higher EPO, GDF15, SF and sTfR levels compared with non-iron overload patients.	Iron	11-15	erythropoietin	Homo sapiens	36-39
30873897-6	2019	In contrast, half-life times of 35-40 min can only be achieved under mildly acidic conditions with FORSUD for iron concentrations higher than 10 mg L-1.	Iron	110-114	L1 cell adhesion molecule	Homo sapiens	148-151
30681573-1	2019	RATIONALE: Pantothenate kinase-associated neurodegeneration (PKAN), also called Hallervorden-Spatz Syndrome (HSS), is a rare neurodegeneration with brain iron accumulation from pantothenate kinase 2 gene (PANK2) mutation characterized as extrapyramidal symptoms.	Iron	154-158	pantothenate kinase 2	Homo sapiens	11-59
30681573-1	2019	RATIONALE: Pantothenate kinase-associated neurodegeneration (PKAN), also called Hallervorden-Spatz Syndrome (HSS), is a rare neurodegeneration with brain iron accumulation from pantothenate kinase 2 gene (PANK2) mutation characterized as extrapyramidal symptoms.	Iron	154-158	pantothenate kinase 2	Homo sapiens	61-65
30681573-1	2019	RATIONALE: Pantothenate kinase-associated neurodegeneration (PKAN), also called Hallervorden-Spatz Syndrome (HSS), is a rare neurodegeneration with brain iron accumulation from pantothenate kinase 2 gene (PANK2) mutation characterized as extrapyramidal symptoms.	Iron	154-158	pantothenate kinase 2	Homo sapiens	177-198
31588368-3	2019	Several molecular targets have been implicated in the pathophysiology of AD, such as the tau (tau) protein, Amyloid-beta (Abeta), the Amyloid Precursor Protein (APP) and more and several responses have also been observed in the advancement of the disease, such as reduced neurogenesis, neuroinflammation, oxidative stress and iron overload.	Iron	326-330	amyloid beta precursor protein	Homo sapiens	134-159
30302010-1	2019	PLA2G6-associated neurodegeneration (PLAN) comprises heterogeneous neurodegenerative disorders, including infantile neuroaxonal dystrophy, neurodegeneration with brain iron accumulation 2B, and Parkinson disease 14 (PARK14).	Iron	168-172	phospholipase A2 group VI	Homo sapiens	0-6
30624674-0	2019	Maternal and Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Increases Infants" Iron Status at 18 Months of Age in a Semiurban Setting in Ghana: A Secondary Outcome Analysis of the iLiNS-DYAD Randomized Controlled Trial.	Iron	108-112	renin binding protein	Homo sapiens	136-139
30572266-7	2019	Patients with hepatic iron overload had higher mean ferritin levels (1182 ng/mL versus 185 ng/mL, p &lt; 0.0001), transferrin saturation (76% versus 34%, p &lt; 0.0001) and lower survival rates.	Iron	22-26	transferrin	Homo sapiens	114-125
30454663-7	2019	Furthermore, the mislocalization of Tat-dependent proteins disturbs iron and molybdenum homeostasis and impairs the cell envelope integrity.	Iron	68-72	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	36-39
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	5-9	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	59-64
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	87-91	Isa2p	Saccharomyces cerevisiae S288C	52-57
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	87-91	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	59-64
30402883-8	2019	Therefore, it appears that perturbation in iron homoeostasis has essential role in HLA-DR mediated antigen presentation and innate armoury by downregulating iNOS as well as altering IFN-gamma, IL-6 and IL-10 profiles.	Iron	43-47	interferon gamma	Homo sapiens	182-191
30402883-7	2019	VL cases had decreased iron uptake by transferrin-dependent and transferrin-independent routes while elevated hepcidin, degraded sole iron exporter ferroportin.	Iron	23-27	transferrin	Homo sapiens	38-49
30402883-8	2019	Therefore, it appears that perturbation in iron homoeostasis has essential role in HLA-DR mediated antigen presentation and innate armoury by downregulating iNOS as well as altering IFN-gamma, IL-6 and IL-10 profiles.	Iron	43-47	interleukin 6	Homo sapiens	193-197
30402883-7	2019	VL cases had decreased iron uptake by transferrin-dependent and transferrin-independent routes while elevated hepcidin, degraded sole iron exporter ferroportin.	Iron	23-27	transferrin	Homo sapiens	64-75
31050989-8	2019	The ceruloplasmin activity and the transferrin saturation in blood plasma by iron were determined by G. Babenko"s method.	Iron	77-81	transferrin	Homo sapiens	35-46
30798809-7	2019	Relationships between increased production of IL-1beta and dysregulated iron metabolism have been suggested in various diseases, which may be linked to overproduction of hepcidin.	Iron	72-76	interleukin 1 beta	Homo sapiens	46-54
30420567-3	2019	Here, we dissected genetic relationships among these three key components and found that (1) STOP1, ALMT1, and LPR1 act downstream of ALS3/STAR1 in controlling PR growth under Pi deficiency; (2) ALS3/STAR1 inhibits the STOP1-ALMT1 pathway by repressing STOP1 protein accumulation in the nucleus; and (3) STOP1-ALMT1 and LPR1 control PR growth under Pi deficiency in an interdependent manner involving the promotion of malate-dependent Fe accumulation in roots.	Iron	435-437	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	93-98
30420567-3	2019	Here, we dissected genetic relationships among these three key components and found that (1) STOP1, ALMT1, and LPR1 act downstream of ALS3/STAR1 in controlling PR growth under Pi deficiency; (2) ALS3/STAR1 inhibits the STOP1-ALMT1 pathway by repressing STOP1 protein accumulation in the nucleus; and (3) STOP1-ALMT1 and LPR1 control PR growth under Pi deficiency in an interdependent manner involving the promotion of malate-dependent Fe accumulation in roots.	Iron	435-437	aluminum-activated malate transporter 1	Arabidopsis thaliana	100-105
30420567-3	2019	Here, we dissected genetic relationships among these three key components and found that (1) STOP1, ALMT1, and LPR1 act downstream of ALS3/STAR1 in controlling PR growth under Pi deficiency; (2) ALS3/STAR1 inhibits the STOP1-ALMT1 pathway by repressing STOP1 protein accumulation in the nucleus; and (3) STOP1-ALMT1 and LPR1 control PR growth under Pi deficiency in an interdependent manner involving the promotion of malate-dependent Fe accumulation in roots.	Iron	435-437	aluminum sensitive 3	Arabidopsis thaliana	134-138
30420567-3	2019	Here, we dissected genetic relationships among these three key components and found that (1) STOP1, ALMT1, and LPR1 act downstream of ALS3/STAR1 in controlling PR growth under Pi deficiency; (2) ALS3/STAR1 inhibits the STOP1-ALMT1 pathway by repressing STOP1 protein accumulation in the nucleus; and (3) STOP1-ALMT1 and LPR1 control PR growth under Pi deficiency in an interdependent manner involving the promotion of malate-dependent Fe accumulation in roots.	Iron	435-437	aluminum sensitive 3	Arabidopsis thaliana	195-199
31318328-1	2019	Transferrin is an iron binding glycoprotein actively involved in the growth and maintenance of cell cycle.	Iron	18-22	transferrin	Homo sapiens	0-11
31318328-2	2019	The transferrin receptors expression is increased on growing cancer/tumor cells for absorption of iron through transferrin and participation in biological activity.	Iron	98-102	transferrin	Homo sapiens	4-15
31318328-6	2019	Purified transferrin was characterized by SDS-PAGE, MALDI-TOF, ELISA, Western blot, and its activity was further confirmed by iron binding assay and receptor binding assays.	Iron	126-130	transferrin	Homo sapiens	9-20
31266660-7	2019	Intravenous iron did not reduce the percentage of transfused patients (56% vs. 44%), but it did reduce the number of blood units required (0.7 units less in IS/EPO group).	Iron	12-16	erythropoietin	Homo sapiens	160-163
31672495-1	2019	AIM: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism.	Iron	157-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-35
31672495-1	2019	AIM: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism.	Iron	157-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
30383305-4	2019	However, animals transfused with 35-day-old RBCs stored at higher temperatures developed plasma elevations in non-transferrin-bound iron and cell-free hemoglobin at 24 and 72 hours.	Iron	132-136	transferrin	Homo sapiens	114-125
30396103-2	2019	We hypothesized that amending bioretention cells with biochar and zero-valent iron (ZVI) could improve the NO3- removal performance.	Iron	78-82	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
30396103-2	2019	We hypothesized that amending bioretention cells with biochar and zero-valent iron (ZVI) could improve the NO3- removal performance.	Iron	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
30396103-5	2019	Compared to the Control cell without amendments, the Biochar/ZVI cell increased water retention by 11-27% and mean residence time by 0.7-3.8 h. The vadose zone of the Biochar/ZVI cell removed 30.6-95.7% (0.6-12.7 g) of NO3-N from the influent, as compared with -6.1-89.6% (-0.1-2.9 g) by that of the Control cell.	Iron	61-64	NBL1, DAN family BMP antagonist	Homo sapiens	219-222
30396103-8	2019	The saturation zone with ZVI amendment further promoted NO3- removal: removal was 1.8 times greater relative to the control in the first infiltration test, but was minimal in following tests.	Iron	25-28	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
30396103-9	2019	The reduction in performance of the ZVI amendment in subsequent tests might be due to diminished NO3-N input to the saturation zone after treatment by the biochar-amended vadose zone.	Iron	36-39	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
31050989-11	2019	The saturation of blood plasma transferrin by iron was significantly reduced - for 15.27 % in patients with severe course of influenza stomatitis.	Iron	46-50	transferrin	Homo sapiens	31-42
30055098-0	2018	Baseline hepcidin measurement in the differential diagnosis of anaemia for elderly patients and its correlation with the increment of transferrin saturation following an oral iron absorption test.	Iron	175-179	transferrin	Homo sapiens	134-145
30596656-1	2018	The bloodstream form of the parasite Trypanosoma brucei obtains iron from its mammalian host by receptor-mediated endocytosis of host transferrin through its own unique transferrin receptor (TbTfR).	Iron	64-68	transferrin	Homo sapiens	134-145
30465670-1	2018	Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.	Iron	21-23	catalase	Homo sapiens	128-136
30465670-1	2018	Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.	Iron	21-23	catalase	Homo sapiens	138-141
30465670-1	2018	Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.	Iron	21-23	superoxide dismutase 1	Homo sapiens	147-167
30465670-1	2018	Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.	Iron	21-23	superoxide dismutase 1	Homo sapiens	169-172
30643404-0	2019	Albumin binding, anticancer and antibacterial properties of synthesized zero valent iron nanoparticles.	Iron	84-88	albumin	Homo sapiens	0-7
30366982-0	2018	FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.	Iron	104-108	family with sequence similarity 210, member B	Mus musculus	0-7
30366982-5	2018	Fam210b deficiency led to defects in mitochondrial iron uptake, heme synthesis, and iron-sulfur cluster formation.	Iron	51-55	family with sequence similarity 210, member B	Mus musculus	0-7
30366982-5	2018	Fam210b deficiency led to defects in mitochondrial iron uptake, heme synthesis, and iron-sulfur cluster formation.	Iron	84-88	family with sequence similarity 210, member B	Mus musculus	0-7
30366982-7	2018	Genetic complementation experiments revealed that FAM210B is not a mitochondrial iron transporter but is required for adequate mitochondrial iron import to sustain heme synthesis and iron-sulfur cluster formation during erythroid differentiation.	Iron	81-85	family with sequence similarity 210, member B	Mus musculus	50-57
30366982-7	2018	Genetic complementation experiments revealed that FAM210B is not a mitochondrial iron transporter but is required for adequate mitochondrial iron import to sustain heme synthesis and iron-sulfur cluster formation during erythroid differentiation.	Iron	141-145	family with sequence similarity 210, member B	Mus musculus	50-57
30366982-9	2018	We propose that FAM210B functions as an adaptor protein that facilitates the formation of an oligomeric mitochondrial iron transport complex, required for the increase in iron acquisition for heme synthesis during terminal erythropoiesis.	Iron	118-122	family with sequence similarity 210, member B	Mus musculus	16-23
30366982-9	2018	We propose that FAM210B functions as an adaptor protein that facilitates the formation of an oligomeric mitochondrial iron transport complex, required for the increase in iron acquisition for heme synthesis during terminal erythropoiesis.	Iron	171-175	family with sequence similarity 210, member B	Mus musculus	16-23
30899874-9	2019	The association between IL-6 and hemoglobin in children with CKD remained significant after adjustment for CKD stage, iron therapy, and hepcidin.	Iron	118-122	interleukin 6	Homo sapiens	24-28
30544934-7	2018	Intravenous iron should be the first line treatment in patients with moderate-severe anaemia, in patients with active disease, in patients with poor tolerance to oral iron and when erythropoietin agents or a fast response is needed.	Iron	12-16	erythropoietin	Homo sapiens	181-195
30460953-0	2018	New aspects of iron-copper crosstalk uncovered by transcriptomic characterization of Col-0 and the copper uptake mutant spl7 in Arabidopsis thaliana.	Iron	15-19	squamosa promoter binding protein-like 7	Arabidopsis thaliana	120-124
30460953-5	2018	The spl7 mutant accumulated excess Fe under normal conditions, and lower Fe supply rescued the growth phenotype and normalized the Fe : Cu ratios.	Iron	35-37	squamosa promoter binding protein-like 7	Arabidopsis thaliana	4-8
30460953-7	2018	Expression patterns indicated that both SPL7 and the FIT Fe uptake transcription factor influenced the expression of many key Fe uptake genes.	Iron	126-128	squamosa promoter binding protein-like 7	Arabidopsis thaliana	40-44
30446224-0	2018	Retinoic acid modulates iron metabolism imbalance in anemia of inflammation induced by LPS via reversely regulating hepcidin and ferroportin expression.	Iron	24-28	toll-like receptor 4	Mus musculus	87-90
28793787-0	2018	The Roles of NRF2 in Modulating Cellular Iron Homeostasis.	Iron	41-45	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
28793787-4	2018	The nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor, which can respond to oxidative and electrophilic stress, regulates several genes involved in iron metabolism.	Iron	170-174	NFE2 like bZIP transcription factor 2	Homo sapiens	4-47
28793787-4	2018	The nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor, which can respond to oxidative and electrophilic stress, regulates several genes involved in iron metabolism.	Iron	170-174	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
28793787-6	2018	Recent works have identified that several genes involved in heme synthesis, hemoglobin catabolism, iron storage, and iron export are under the control of NRF2.	Iron	99-103	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
28793787-6	2018	Recent works have identified that several genes involved in heme synthesis, hemoglobin catabolism, iron storage, and iron export are under the control of NRF2.	Iron	117-121	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
28793787-7	2018	Constitutive NRF2 activation and subsequent deregulation of iron metabolism have been implicated in cancer development: NRF2-mediated upregulation of the iron storage protein ferritin or heme oxygenase 1 can lead to enhanced proliferation and therapy resistance.	Iron	60-64	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
28793787-7	2018	Constitutive NRF2 activation and subsequent deregulation of iron metabolism have been implicated in cancer development: NRF2-mediated upregulation of the iron storage protein ferritin or heme oxygenase 1 can lead to enhanced proliferation and therapy resistance.	Iron	154-158	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
28793787-7	2018	Constitutive NRF2 activation and subsequent deregulation of iron metabolism have been implicated in cancer development: NRF2-mediated upregulation of the iron storage protein ferritin or heme oxygenase 1 can lead to enhanced proliferation and therapy resistance.	Iron	154-158	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
28793787-8	2018	Of note, NRF2 activation and alterations to iron signaling in cancers may hinder efforts to induce the iron-dependent cell death process known as ferroptosis.	Iron	103-107	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
28793787-9	2018	CRITICAL ISSUES: Despite growing recognition of NRF2 as a modulator of iron signaling, exactly how iron metabolism is altered due to NRF2 activation in normal physiology and in pathologic conditions remains imprecise; moreover, the roles of NRF2-mediated iron signaling changes in disease progression are only beginning to be uncovered.	Iron	71-75	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
28793787-9	2018	CRITICAL ISSUES: Despite growing recognition of NRF2 as a modulator of iron signaling, exactly how iron metabolism is altered due to NRF2 activation in normal physiology and in pathologic conditions remains imprecise; moreover, the roles of NRF2-mediated iron signaling changes in disease progression are only beginning to be uncovered.	Iron	99-103	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
28793787-9	2018	CRITICAL ISSUES: Despite growing recognition of NRF2 as a modulator of iron signaling, exactly how iron metabolism is altered due to NRF2 activation in normal physiology and in pathologic conditions remains imprecise; moreover, the roles of NRF2-mediated iron signaling changes in disease progression are only beginning to be uncovered.	Iron	99-103	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
28793787-9	2018	CRITICAL ISSUES: Despite growing recognition of NRF2 as a modulator of iron signaling, exactly how iron metabolism is altered due to NRF2 activation in normal physiology and in pathologic conditions remains imprecise; moreover, the roles of NRF2-mediated iron signaling changes in disease progression are only beginning to be uncovered.	Iron	99-103	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
28793787-9	2018	CRITICAL ISSUES: Despite growing recognition of NRF2 as a modulator of iron signaling, exactly how iron metabolism is altered due to NRF2 activation in normal physiology and in pathologic conditions remains imprecise; moreover, the roles of NRF2-mediated iron signaling changes in disease progression are only beginning to be uncovered.	Iron	99-103	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
28793787-10	2018	FUTURE DIRECTIONS: Further studies are necessary to connect NRF2 activation with physiological and pathological changes to iron signaling and oxidative stress.	Iron	123-127	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
30446224-8	2018	RA modulates iron metabolism imbalance in AI induced by LPS via reversely regulating hepcidin and ferroportin expression, which might be mediated by TLT-4/NFkappaB signaling pathway.	Iron	13-17	toll-like receptor 4	Mus musculus	56-59
20301613-5	1993	DIAGNOSIS/TESTING: The diagnosis of clinical HFE-HH in individuals with clinical findings consistent with HFE-HH and the diagnosis of biochemical HFE-HH are typically based on finding elevated transferrin-iron saturation 45% or higher and serum ferritin concentration above the upper limit of normal (i.e., &gt;300 ng/mL in men and &gt;200 ng/mL in women) and two pathogenic variants on confirmatory HFE molecular genetic testing.	Iron	205-209	transferrin	Homo sapiens	193-204
30518272-3	2018	A high expression level can lead to iron overload diseases, whereas mutations in the gene encoding MT2, TMPRSS6, may result in various forms of iron deficiency anemia.	Iron	36-40	transmembrane serine protease 6	Homo sapiens	99-102
30117045-12	2018	Iron overload in the neonatal period reduced, while treatment with DFP was able to rescue, the expression of antioxidant enzymes CAT and NQO1.	Iron	0-4	catalase	Rattus norvegicus	129-132
30518272-3	2018	A high expression level can lead to iron overload diseases, whereas mutations in the gene encoding MT2, TMPRSS6, may result in various forms of iron deficiency anemia.	Iron	36-40	transmembrane serine protease 6	Homo sapiens	104-111
30422643-2	2018	This strategy enables the sustained performance of copper catalysts in distilled and tap water electrolytes for over 12 h. The deposition of common electrolyte impurities such as iron, nickel, and zinc is blocked because EDTA can effectively bind the metal ions and negatively shift the electrode potential of M/M n+.	Iron	179-183	SEC14 like lipid binding 2	Homo sapiens	85-88
30178146-0	2018	Response to Letter to the Editor: "Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet"".	Iron	116-120	transferrin	Homo sapiens	74-85
30279145-0	2018	Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using 55Fe and storage phosphorimaging.	Iron	30-34	transferrin	Rattus norvegicus	48-59
30251657-3	2018	THB1, which is cytoplasmic and capable of nitric oxide dioxygenation activity, uses a histidine and a lysine as axial ligands to the heme iron.	Iron	138-142	uncharacterized protein	Chlamydomonas reinhardtii	0-4
30117045-12	2018	Iron overload in the neonatal period reduced, while treatment with DFP was able to rescue, the expression of antioxidant enzymes CAT and NQO1.	Iron	0-4	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	137-141
30311019-2	2018	These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow.	Iron	84-88	transferrin	Homo sapiens	150-161
30311019-2	2018	These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow.	Iron	129-133	transferrin	Homo sapiens	150-161
30311019-2	2018	These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow.	Iron	129-133	transferrin	Homo sapiens	150-161
30311019-5	2018	In this study, we show that FPC can directly transfer iron to apo-transferrin.	Iron	54-58	transferrin	Homo sapiens	66-77
30311019-6	2018	Kinetic analyses reveal that FPC donates iron to apo-transferrin with fast binding kinetics.	Iron	41-45	transferrin	Homo sapiens	53-64
30311019-7	2018	In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure.	Iron	89-93	transferrin	Homo sapiens	38-49
30311019-7	2018	In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure.	Iron	89-93	transferrin	Homo sapiens	138-149
30311019-7	2018	In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure.	Iron	102-106	transferrin	Homo sapiens	38-49
30311019-7	2018	In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure.	Iron	102-106	transferrin	Homo sapiens	138-149
30193233-4	2018	The results showed that the introduction of surfactants significantly influenced the reduction of 2,2",5,5"-tetrachlorinated biphenyl (PCB-52) by altering the contact between ZVI and PCB-52.	Iron	175-178	pyruvate carboxylase	Homo sapiens	135-138
30296647-10	2018	The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.	Iron	36-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	115-149
30209795-3	2018	As such, apart from its classical role in energy production, membrane-bound GAPDH is required for membrane fusion, endocytosis and, intriguingly, for iron transport.	Iron	150-154	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	76-81
30172039-16	2018	Moreover, dysregulation of iron homeostasis may be due to MC-LR-induced Hamp1 downregulation, possibly mediated by hypoxia or the IL6-STAT3 and BMP-SMAD signaling pathways.	Iron	27-31	interleukin 6	Mus musculus	130-133
30172039-16	2018	Moreover, dysregulation of iron homeostasis may be due to MC-LR-induced Hamp1 downregulation, possibly mediated by hypoxia or the IL6-STAT3 and BMP-SMAD signaling pathways.	Iron	27-31	signal transducer and activator of transcription 3	Mus musculus	134-139
30193233-4	2018	The results showed that the introduction of surfactants significantly influenced the reduction of 2,2",5,5"-tetrachlorinated biphenyl (PCB-52) by altering the contact between ZVI and PCB-52.	Iron	175-178	pyruvate carboxylase	Homo sapiens	183-186
30193233-6	2018	However, the reduction of ZVI by humic acid decreased the electron transfer efficiency of ZVI, and also reduced the contact between ZVI and PCB-52 by generating FeCO3.	Iron	26-29	pyruvate carboxylase	Homo sapiens	140-143
29764240-1	2018	Iron or oxygen regulates the stability of hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-73
30287942-0	2018	Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.	Iron	13-17	translocase of outer mitochondrial membrane 20	Homo sapiens	0-5
30287942-3	2018	Here, we demonstrate that iron-activated ROS can induce pyroptosis via a Tom20-Bax-caspase-GSDME pathway.	Iron	26-30	translocase of outer mitochondrial membrane 20	Homo sapiens	73-78
30287942-3	2018	Here, we demonstrate that iron-activated ROS can induce pyroptosis via a Tom20-Bax-caspase-GSDME pathway.	Iron	26-30	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
30287942-4	2018	In melanoma cells, iron enhanced ROS signaling initiated by CCCP, causing the oxidation and oligomerization of the mitochondrial outer membrane protein Tom20.	Iron	19-23	translocase of outer mitochondrial membrane 20	Homo sapiens	152-157
30287942-6	2018	Therefore, ROS acts as a causative factor and Tom20 senses ROS signaling for iron-driven pyroptotic death of melanoma cells.	Iron	77-81	translocase of outer mitochondrial membrane 20	Homo sapiens	46-51
29050649-0	2018	Obesity status influences the relationship among serum osteocalcin, iron stores and insulin sensitivity.	Iron	68-72	insulin	Homo sapiens	84-91
29050649-2	2018	Recent studies have shown that iron overload decreases osteocalcin.	Iron	31-35	bone gamma-carboxyglutamate protein	Homo sapiens	55-66
29050649-3	2018	We aimed to explore the relationship among osteocalcin, iron stores and insulin sensitivity.	Iron	56-60	insulin	Homo sapiens	72-79
29050649-9	2018	CONCLUSIONS: The association of circulating osteocalcin with parameters of insulin sensitivity and iron stores were dependent on obesity status.	Iron	99-103	bone gamma-carboxyglutamate protein	Homo sapiens	44-55
30225625-0	2018	Correction to: Iron metabolism in diabetes-induced Alzheimer"s disease: a focus on insulin resistance in the brain.	Iron	15-19	insulin	Homo sapiens	83-90
29764240-1	2018	Iron or oxygen regulates the stability of hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-85
30702074-7	2018	The etiology of primary (idiopathic) RLS has not been clarified yet; however, genetic factors and dysfunctional dopaminergic neurotransmission as well as alterations of central iron metabolism play an important role.	Iron	177-181	RLS1	Homo sapiens	37-40
30506659-3	2018	Therefore, iron trafficking is firmly regulated by Hepcidin (Hamp), which is regarded as the marker for iron accumulation.	Iron	11-15	hepcidin antimicrobial peptide	Rattus norvegicus	51-59
30506659-3	2018	Therefore, iron trafficking is firmly regulated by Hepcidin (Hamp), which is regarded as the marker for iron accumulation.	Iron	11-15	hepcidin antimicrobial peptide	Rattus norvegicus	61-65
30506659-3	2018	Therefore, iron trafficking is firmly regulated by Hepcidin (Hamp), which is regarded as the marker for iron accumulation.	Iron	104-108	hepcidin antimicrobial peptide	Rattus norvegicus	51-59
30506659-3	2018	Therefore, iron trafficking is firmly regulated by Hepcidin (Hamp), which is regarded as the marker for iron accumulation.	Iron	104-108	hepcidin antimicrobial peptide	Rattus norvegicus	61-65
30555088-3	2018	Notably, recent studies have demonstrated an association between body iron stores, insulin resistance and T2DM.	Iron	70-74	insulin	Homo sapiens	83-90
30145824-2	2018	Bach1 is a mammalian transcription factor that represses Hmox1, which encodes heme oxygenase-1 (HO-1) that can degrade heme into free iron, carbon monoxide, and biliverdin, to play an important role in antioxidant, anti-inflammatory, and antiapoptotic activities.	Iron	134-138	BTB domain and CNC homolog 1	Homo sapiens	0-5
30501711-1	2018	OBJECTIVE: To study the effects of iron metabolism abnormality on EPO-STAT5 signaling pathway in anemia patients.	Iron	35-39	erythropoietin	Homo sapiens	66-69
30341443-2	2018	In the Discussion, the sentence "In line with this, Ep-CAM-deficient mice exhibited increased intestinal permeability and decreased ion transport60, which may contribute to CVD susceptibility risk59" originally read iron instead of ion transport.	Iron	216-220	epithelial cell adhesion molecule	Mus musculus	52-58
30392167-1	2018	Neurodegeneration with brain iron accumulation type 4 (NBIA4) also known as MPAN (mitochondria protein-associated neurodegeneration) is a rare neurological disorder which main feature is brain iron accumulation most frequently in the globus pallidus and substantia nigra.	Iron	29-33	WD repeat domain 45	Homo sapiens	55-60
30392167-1	2018	Neurodegeneration with brain iron accumulation type 4 (NBIA4) also known as MPAN (mitochondria protein-associated neurodegeneration) is a rare neurological disorder which main feature is brain iron accumulation most frequently in the globus pallidus and substantia nigra.	Iron	193-197	WD repeat domain 45	Homo sapiens	55-60
30033906-7	2018	Biochemically, Fe and Zn in insects occur predominantly in non-haem forms, bound to the proteins ferritin, transferrin and other transport and storage proteins.	Iron	15-17	transferrin	Homo sapiens	107-118
30267477-0	2018	Proteomic Profiling of Iron-Treated Ovarian Cells Identifies AKT Activation that Modulates the CLEAR Network.	Iron	23-27	AKT serine/threonine kinase 1	Homo sapiens	61-64
30267477-8	2018	Collectively, these findings support use of RPPA/IPA technology to predict functional responses to iron and further implicate AKT pathway and MiTF members in iron-induced cellular responses in ovarian cells.	Iron	158-162	AKT serine/threonine kinase 1	Homo sapiens	126-129
30571402-4	2018	Methods- A study of 48 972 subjects performed by the Genetics of Iron Status consortium identified genetic variants with concordant relations to 4 biomarkers of iron status (serum iron, transferrin saturation, ferritin, and transferrin) that supported their use as instruments for overall iron status.	Iron	65-69	transferrin	Homo sapiens	186-197
30571402-4	2018	Methods- A study of 48 972 subjects performed by the Genetics of Iron Status consortium identified genetic variants with concordant relations to 4 biomarkers of iron status (serum iron, transferrin saturation, ferritin, and transferrin) that supported their use as instruments for overall iron status.	Iron	65-69	transferrin	Homo sapiens	224-235
30571402-7	2018	Results- The main results, reported as odds ratio (OR) of stroke per SD unit increase in genetically determined iron status biomarker, showed a detrimental effect of increased iron status on stroke risk (serum iron OR, 1.07; 95% CI, 1.01-1.14; [log-transformed] ferritin OR, 1.18; 95% CI, 1.02-1.36; and transferrin saturation OR, 1.06; 95% CI, 1.01-1.11).	Iron	112-116	transferrin	Homo sapiens	304-315
30571402-7	2018	Results- The main results, reported as odds ratio (OR) of stroke per SD unit increase in genetically determined iron status biomarker, showed a detrimental effect of increased iron status on stroke risk (serum iron OR, 1.07; 95% CI, 1.01-1.14; [log-transformed] ferritin OR, 1.18; 95% CI, 1.02-1.36; and transferrin saturation OR, 1.06; 95% CI, 1.01-1.11).	Iron	176-180	transferrin	Homo sapiens	304-315
30571402-7	2018	Results- The main results, reported as odds ratio (OR) of stroke per SD unit increase in genetically determined iron status biomarker, showed a detrimental effect of increased iron status on stroke risk (serum iron OR, 1.07; 95% CI, 1.01-1.14; [log-transformed] ferritin OR, 1.18; 95% CI, 1.02-1.36; and transferrin saturation OR, 1.06; 95% CI, 1.01-1.11).	Iron	176-180	transferrin	Homo sapiens	304-315
30571402-8	2018	A higher transferrin, indicative of lower iron status, was also associated with decreased stroke risk (OR, 0.92; 95% CI, 0.86-0.99).	Iron	42-46	transferrin	Homo sapiens	9-20
30501711-5	2018	Moreover, the effects of iron metabolism abnormality on the expression of EPO and STAT5 in anemia patients were analyzed.	Iron	25-29	erythropoietin	Homo sapiens	74-77
30501711-6	2018	RESULTS: compared with non-iron over load group, the EPO level in iron over load group significantly increased (P&lt;0.05), the expression of STAT5 mRNA and P-STAT5 significantly decreased (P&lt;0.05).	Iron	27-31	erythropoietin	Homo sapiens	53-56
30501711-6	2018	RESULTS: compared with non-iron over load group, the EPO level in iron over load group significantly increased (P&lt;0.05), the expression of STAT5 mRNA and P-STAT5 significantly decreased (P&lt;0.05).	Iron	66-70	erythropoietin	Homo sapiens	53-56
30501711-7	2018	After iron chelation therapy, the EPO level in serum significantly decreased (P&lt;0.05), the expression of STAT5 mRNA and P-STAT5 was up-regulated significantly (P&lt;0.05).	Iron	6-10	erythropoietin	Homo sapiens	34-37
30501711-10	2018	CONCLUSION: The excessive iron load or chronic inflammation may inhibit the activation of EPO-STAT5 signaling pathway and aggravate the anemia.	Iron	26-30	erythropoietin	Homo sapiens	90-93
30501713-4	2018	Transferrin saturation negatively correlated with platelet count and platelet crit(r=-0.353,P&lt;0.01;r=-0.271, P&lt;0.05).Serum ferritin and total iron binding capacity revealed no significant relation with any platelet parameters.Hemoglobin level , hematocrit and mean corpuscular hemoglobin concentration negatively correlated with platelet count(r=-0.239,P&lt;0.05;r=-0.250,P&lt;0.05;r=-0.339,P&lt;0.01).There were differences in iron metabolism indexes and platelet parameters between mild to moderate anemia group and severe anemia group.	Iron	148-152	transferrin	Homo sapiens	0-11
30501713-4	2018	Transferrin saturation negatively correlated with platelet count and platelet crit(r=-0.353,P&lt;0.01;r=-0.271, P&lt;0.05).Serum ferritin and total iron binding capacity revealed no significant relation with any platelet parameters.Hemoglobin level , hematocrit and mean corpuscular hemoglobin concentration negatively correlated with platelet count(r=-0.239,P&lt;0.05;r=-0.250,P&lt;0.05;r=-0.339,P&lt;0.01).There were differences in iron metabolism indexes and platelet parameters between mild to moderate anemia group and severe anemia group.	Iron	434-438	transferrin	Homo sapiens	0-11
30501713-6	2018	CONCLUSION: The important iron metabolism indexes affecting platelet count are serum iron and transferrin saturation,that is,the severer iron deficiency, the higher platelet count.Patients with more severe and hypochronic anemia has higher platelet count.	Iron	26-30	transferrin	Homo sapiens	94-105
30646653-7	2018	Conclusion: Macrophages and IL-8 may play an important role in the pathogenesis of airway inflammation after long-term inhalation of iron and its compounds, the airway function in patients of occupational pulmonary thesaurosis was found damaged.	Iron	133-137	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
30462940-0	2018	Iron Wars - The Host Strikes Back.	Iron	0-4	tryptophanyl-tRNA synthetase 1	Homo sapiens	5-9
30584425-6	2018	On the other hand, iron overload increased IL6 and reduced IL10 in small intestinal tissues reflecting inflammatory condition and increased caspase 3 reactivity indicating apoptosis and increased iNOs expressing cell indicting oxidative stress especially in ileum.	Iron	19-23	interleukin 6	Rattus norvegicus	43-46
30584425-6	2018	On the other hand, iron overload increased IL6 and reduced IL10 in small intestinal tissues reflecting inflammatory condition and increased caspase 3 reactivity indicating apoptosis and increased iNOs expressing cell indicting oxidative stress especially in ileum.	Iron	19-23	nitric oxide synthase 2	Rattus norvegicus	196-200
30510932-2	2018	Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron (NTBI).	Iron	20-24	transferrin	Homo sapiens	176-187
30510932-2	2018	Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron (NTBI).	Iron	194-198	transferrin	Homo sapiens	176-187
30362701-5	2018	The arrays of CoFe oxide nanosheets (NSs) grown on CFP (Co2.3Fe0.7O4-NSs/CFP) deliver lower Tafel slope (34.3 mV dec-1) than CoFe oxide nanowire (NW) arrays grown on CFP (Co2.7Fe0.3O4-NWs/CFP) in alkaline solution, owing to higher Fe-doping content and larger effective specific surface area.	Iron	16-18	complement factor properdin	Homo sapiens	51-54
30362701-5	2018	The arrays of CoFe oxide nanosheets (NSs) grown on CFP (Co2.3Fe0.7O4-NSs/CFP) deliver lower Tafel slope (34.3 mV dec-1) than CoFe oxide nanowire (NW) arrays grown on CFP (Co2.7Fe0.3O4-NWs/CFP) in alkaline solution, owing to higher Fe-doping content and larger effective specific surface area.	Iron	16-18	complement factor properdin	Homo sapiens	73-76
30362701-5	2018	The arrays of CoFe oxide nanosheets (NSs) grown on CFP (Co2.3Fe0.7O4-NSs/CFP) deliver lower Tafel slope (34.3 mV dec-1) than CoFe oxide nanowire (NW) arrays grown on CFP (Co2.7Fe0.3O4-NWs/CFP) in alkaline solution, owing to higher Fe-doping content and larger effective specific surface area.	Iron	16-18	complement factor properdin	Homo sapiens	73-76
30362701-5	2018	The arrays of CoFe oxide nanosheets (NSs) grown on CFP (Co2.3Fe0.7O4-NSs/CFP) deliver lower Tafel slope (34.3 mV dec-1) than CoFe oxide nanowire (NW) arrays grown on CFP (Co2.7Fe0.3O4-NWs/CFP) in alkaline solution, owing to higher Fe-doping content and larger effective specific surface area.	Iron	16-18	complement factor properdin	Homo sapiens	73-76
30387800-0	2018	Insights into the influence of ethylene group orientation on the iron(iii) spin state in the spin crossover complex [FeIII(Sal2-trien)].	Iron	65-69	spalt like transcription factor 2	Homo sapiens	123-127
30584425-4	2018	Results: Iron overloaded group showed significant increase in serum iron, total iron binding capacity (TIBC), transferrin saturation percentage (TS %) hepcidin (HEPC), serum ferritin, nontransferrin bound iron (NTBI), and small intestinal tissues iron levels.	Iron	9-13	transferrin	Rattus norvegicus	110-121
30584425-4	2018	Results: Iron overloaded group showed significant increase in serum iron, total iron binding capacity (TIBC), transferrin saturation percentage (TS %) hepcidin (HEPC), serum ferritin, nontransferrin bound iron (NTBI), and small intestinal tissues iron levels.	Iron	9-13	hepcidin antimicrobial peptide	Rattus norvegicus	151-159
30584425-4	2018	Results: Iron overloaded group showed significant increase in serum iron, total iron binding capacity (TIBC), transferrin saturation percentage (TS %) hepcidin (HEPC), serum ferritin, nontransferrin bound iron (NTBI), and small intestinal tissues iron levels.	Iron	9-13	hepcidin antimicrobial peptide	Rattus norvegicus	161-165
30746416-1	2019	Background and Methods: Mutations in WDR45 cause beta-propeller protein-associated neurodegeneration (BPAN), a type of neurodegeneration with brain iron accumulation (NBIA).	Iron	148-152	WD repeat domain 45	Homo sapiens	37-42
30381181-2	2018	The zero-field splitting (ZFS) parameters, D- and E-values, are very close to the reported values,  D  = 0.25 cm-1 and  E/D  = 0.06, for an Fe-transferrin with oxalate anion, and to  D  = 0.25 cm-1 and  E/D  = 0.04 for one with malonate anion in human sera, suggesting that the Fe3+ species are from Fe-transferrins or their homologues.	Iron	140-142	transferrin	Homo sapiens	143-154
30483293-12	2018	By contrast, translation state of chloroplast SUFE2 in persulfide formation and cytosolic Fe-S cluster formation scaffold protein NBP35 reached maxima in translation state during the day.	Iron	90-94	nucleotide binding protein 35	Arabidopsis thaliana	130-135
30662597-5	2018	Among them, an iron-containing gene, PolE, the catalytic subunit of DNA polymerase epsilon (Polepsilon), and the other two Polepsilon subunits, including PolE2 and PolE3, were markedly downregulated, while some proteins involved in apoptosis such as Caspase-3 and -8 were significantly upregulated.	Iron	15-19	DNA polymerase epsilon 2, accessory subunit	Homo sapiens	154-159
30662597-5	2018	Among them, an iron-containing gene, PolE, the catalytic subunit of DNA polymerase epsilon (Polepsilon), and the other two Polepsilon subunits, including PolE2 and PolE3, were markedly downregulated, while some proteins involved in apoptosis such as Caspase-3 and -8 were significantly upregulated.	Iron	15-19	caspase 3	Homo sapiens	250-266
30411165-7	2018	The increasing understanding of the role of iron in RLS pathophysiology has led to new options in iron supplementation therapy in RLS, including treatment with ferric carboxymaltose.	Iron	44-48	RLS1	Homo sapiens	52-55
30411165-7	2018	The increasing understanding of the role of iron in RLS pathophysiology has led to new options in iron supplementation therapy in RLS, including treatment with ferric carboxymaltose.	Iron	98-102	RLS1	Homo sapiens	130-133
30395611-9	2018	Furthermore, we demonstrate presence of iron in epithiospecifier protein and nitrile-specifier protein 3 from Arabidopsis thaliana (AtESP and AtNSP3).	Iron	40-44	nitrile specifier protein 3	Arabidopsis thaliana	142-148
30809352-4	2019	Computational studies (DFT) found that the lowest energy isomers of mono-oxygen derivatives of Ni(mu-EPh)(mu-SN2)Fe complexes were those with O attachment to Ni rather than Fe, a result consonant with experimental findings, but at odds with oxygenates found in oxygen-damaged [NiFeS]/[NiFeSe]-H2ase structures.	Iron	113-115	solute carrier family 38 member 5	Homo sapiens	109-112
30809352-4	2019	Computational studies (DFT) found that the lowest energy isomers of mono-oxygen derivatives of Ni(mu-EPh)(mu-SN2)Fe complexes were those with O attachment to Ni rather than Fe, a result consonant with experimental findings, but at odds with oxygenates found in oxygen-damaged [NiFeS]/[NiFeSe]-H2ase structures.	Iron	173-175	solute carrier family 38 member 5	Homo sapiens	109-112
30395611-11	2018	In agreement with this model, iron binding and activity of AtNSP3 depend on E386, D390, and H394.	Iron	30-34	nitrile specifier protein 3	Arabidopsis thaliana	59-65
30106621-8	2018	Plasma I-FABP concentrations during exercise were 264 pg/ml (196 to 332 pg/ml) lower in BE versus FE ( P = 0.01).	Iron	98-100	fatty acid binding protein 2	Homo sapiens	7-13
30383537-3	2018	Using mouse-derived neurons and APP/PS1 transgenic (Tg) mice as model systems, we firstly revealed the mechanisms of APH-1alpha/1beta and presenilin 1 (PS1) upregulation by Fe in prostaglandin (PG) E2- and PGD2-dependent mechanisms.	Iron	173-175	aph1 homolog A, gamma secretase subunit	Mus musculus	117-133
30209767-3	2018	The maximum adsorption capacity of Fe3O4@MOF-100(Fe) for diclofenac sodium can reach 377.36 mg L-1, which was higher than most of the adsorbents reported.	Iron	35-37	immunoglobulin kappa variable 1-16	Homo sapiens	95-98
29524196-3	2018	It competes with iron for transferrin (binding site for transportation) and with lactoferrin as it is secreted in milk also.	Iron	17-21	transferrin	Homo sapiens	26-37
30282605-2	2018	Cyt c possesses also peroxidase-like activity in the native state despite its six-coordinated heme iron.	Iron	99-103	cytochrome c, somatic	Homo sapiens	0-5
29481840-7	2018	In relation to AD, various roles of SELENOP are discussed, i.e. as the means of Se delivery to neurons, as an antioxidant, in cytoskeleton assembly, in interaction with redox-active metals (copper, iron, and mercury) and with misfolded proteins (amyloid-beta and hyperphosphorylated tau-protein).	Iron	198-202	selenoprotein P	Homo sapiens	36-43
30341696-12	2018	As consequence recent novel therapeutic drugs for neurodegenerative diseases has led to the development of multi target drugs, that possess selective brain MAO A and B inhibitory moiety, iron chelating and antioxidant activities and the ability to increase brain levels of endogenous neurotrophins, such as BDNF, GDNF VEGF and erythropoietin and induce mitochondrial biogenesis.	Iron	187-191	erythropoietin	Homo sapiens	327-341
30487665-1	2018	Heme oxygenases (HOs) are rate-limiting enzymes catabolizing heme to biliverdin, ferrous iron, and carbon monoxide, and of the three HO isoforms identified, HO-1 plays a protective role against inflammatory processes.	Iron	81-93	heme oxygenase 1	Mus musculus	157-161
30119015-1	2018	[Fe(NO)2] - modified nanoparticles of low-density protein (DNICLDL) can serve as conveyors of iron in the form of stable complexes with ApoB100 protein.	Iron	94-98	apolipoprotein B	Homo sapiens	136-143
30099506-2	2018	We hypothesized that transcriptional dysregulation of genes involved in iron metabolism in adipocytes causes insulin resistance.	Iron	72-76	insulin	Homo sapiens	109-116
30099506-11	2018	Knockdown of TF in differentiated Simpson-Golabi-Behmel syndrome adipocytes by short hairpin RNA decreased intracellular iron, reduced maximal insulin-stimulated glucose uptake, and reduced Akt phosphorylation.	Iron	121-125	transferrin	Homo sapiens	13-15
30099506-13	2018	Iron chelation recapitulated key changes in the expression profile induced by TF knockdown.	Iron	0-4	transferrin	Homo sapiens	78-80
30209894-1	2018	BACKGROUND: Hereditary myopathy with lactic acidosis (HML) is an autosomal recessive disease caused by an intron mutation in the iron-sulfur cluster assembly (ISCU) gene.	Iron	129-133	iron-sulfur cluster assembly enzyme	Homo sapiens	159-163
29603266-13	2018	It may be speculated that other mechanisms than Fe supplementation contribute to oxidative stress, such as cow"s milk protein-mediated up-regulation of the intestinal inflammatory cascade.	Iron	48-50	casein beta	Bos taurus	113-125
30221726-4	2018	Mutations in these genes lead to severe and progressive movement disorders, with neurodegeneration and iron accumulation in the basal ganglia, known as PANK2- and COASY protein-associated neurodegeneration, respectively.	Iron	103-107	pantothenate kinase 2	Homo sapiens	152-157
30221726-4	2018	Mutations in these genes lead to severe and progressive movement disorders, with neurodegeneration and iron accumulation in the basal ganglia, known as PANK2- and COASY protein-associated neurodegeneration, respectively.	Iron	103-107	Coenzyme A synthase	Homo sapiens	163-168
30095861-9	2018	Rats fed sheep milk had lower iron concentrations in the liver and higher concentrations of rubidium and cesium in all of the soft organs.	Iron	30-34	Weaning weight-maternal milk	Bos taurus	15-19
30232412-5	2018	Hippocampal iron status was assessed by transferrin receptor-1 (Tfrc-1) and divalent metal transporter-1 (Slc11a2) mRNA expression.	Iron	12-16	solute carrier family 11 member 2	Rattus norvegicus	106-113
30003313-2	2018	Ferric pyrophosphate citrate (FPC, Triferic ) donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration.	Iron	54-58	transferrin	Homo sapiens	71-82
30232412-9	2018	Both Ret-He and MCV correlated with brain iron status at P14 and P15.	Iron	42-46	ret proto-oncogene	Rattus norvegicus	5-8
30268500-0	2018	Alternative pathway linked by hydrogen bonds connects heme-Fe of cytochrome c with subunit II-CuA of cytochrome a.	Iron	59-61	cytochrome c, somatic	Homo sapiens	65-77
29864668-9	2018	The co-occurrence of iron and sulfide in filtered soil porewaters, sometimes both above 100 muM, suggests the presence of nanoparticulate and/or colloidal metal sulfides.	Iron	21-25	latexin	Homo sapiens	92-95
30420953-12	2018	Aceruloplasminemia and atransferrinemia are further inherited disorders of iron overload caused by deficiency in ceruloplasmin or transferrin, the plasma ferroxidase and iron carrier, respectively.	Iron	75-79	transferrin	Homo sapiens	24-35
30361476-6	2018	Iron therapy increased serum Fe, ferritin and transferrin saturation as well as cardiac and hepatic iron content in HF rats, but did not increase myocardial ferritin.	Iron	0-4	transferrin	Rattus norvegicus	46-57
30337301-1	2018	Heme oxygenase 1 (HMOX1), the inducible enzyme that catabolizes the degradation of heme into biliverdin, iron, and carbon monoxide, plays an essential role in the clearance of senescent and damaged red blood cells, systemic iron homeostasis, erythropoiesis, vascular hemostasis, and oxidative and inflammatory stress responses.	Iron	105-109	heme oxygenase 1	Mus musculus	0-16
30337301-1	2018	Heme oxygenase 1 (HMOX1), the inducible enzyme that catabolizes the degradation of heme into biliverdin, iron, and carbon monoxide, plays an essential role in the clearance of senescent and damaged red blood cells, systemic iron homeostasis, erythropoiesis, vascular hemostasis, and oxidative and inflammatory stress responses.	Iron	105-109	heme oxygenase 1	Mus musculus	18-23
30337301-1	2018	Heme oxygenase 1 (HMOX1), the inducible enzyme that catabolizes the degradation of heme into biliverdin, iron, and carbon monoxide, plays an essential role in the clearance of senescent and damaged red blood cells, systemic iron homeostasis, erythropoiesis, vascular hemostasis, and oxidative and inflammatory stress responses.	Iron	224-228	heme oxygenase 1	Mus musculus	0-16
30337301-1	2018	Heme oxygenase 1 (HMOX1), the inducible enzyme that catabolizes the degradation of heme into biliverdin, iron, and carbon monoxide, plays an essential role in the clearance of senescent and damaged red blood cells, systemic iron homeostasis, erythropoiesis, vascular hemostasis, and oxidative and inflammatory stress responses.	Iron	224-228	heme oxygenase 1	Mus musculus	18-23
30337301-5	2018	Results showed that WT macrophages engrafted and proliferated in the livers of Hmox1 KO mice, which corrected the microcytic anemia, rescued the intravascular hemolysis, restored iron homeostasis, eliminated kidney iron overload and tissue damage, and provided long-term protection.	Iron	179-183	heme oxygenase 1	Mus musculus	79-84
30337301-5	2018	Results showed that WT macrophages engrafted and proliferated in the livers of Hmox1 KO mice, which corrected the microcytic anemia, rescued the intravascular hemolysis, restored iron homeostasis, eliminated kidney iron overload and tissue damage, and provided long-term protection.	Iron	215-219	heme oxygenase 1	Mus musculus	79-84
30340457-7	2018	As an example, oxidatively damaged transferrin released iron ion, which may mediate Fenton reactions and generate additional reactive oxygen species.	Iron	56-60	transferrin	Homo sapiens	35-46
30341355-10	2018	The radical changes in host-bacteria relationships and bacterial co-occurrence patterns according to the TSAT level also suggested a shift in the bacterial iron supply from transferrin to NTBI when TSAT exceeded 45%.	Iron	156-160	transferrin	Homo sapiens	173-184
30367505-2	2018	The aim of this study was to investigate the role of the association between the dietary intake of iron, copper, zinc, manganese, selenium, and iodine (assessed by 24 recall) with vascular endothelial growth factor variants (rs6921438, rs4416670, rs6993770, and rs10738760), on the risk of MetS.	Iron	99-103	vascular endothelial growth factor A	Homo sapiens	180-214
30356071-0	2018	Enrichment and Quantification of Epitope-specific CD4+ T Lymphocytes using Ferromagnetic Iron-gold and Nickel Nanowires.	Iron	89-93	CD4 molecule	Homo sapiens	50-53
30347796-9	2018	The iron-enriched medium caused a decrease in expression of LDHA and did not influence the concentration of l-lactate.	Iron	4-8	lactate dehydrogenase A	Homo sapiens	60-64
30314357-0	2018	NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-kappaB Function in HeLa Cells.	Iron	18-22	nuclear factor kappa B subunit 1	Homo sapiens	90-99
30230819-5	2018	Time-resolved As(V) and HA interactions with Fe minerals during the kinetic processes were studied using aberration-corrected scanning transmission electron microscopy, chemical extractions, stirred-flow kinetic experiments, and X-ray absorption spectroscopy.	Iron	45-47	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
30230819-6	2018	Based on the experimental results, we developed a mechanistic kinetics model for As(V) fate during Fe mineral transformation.	Iron	99-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-86
30230819-7	2018	Our results demonstrated that the rates of As(V) speciation changes within Fe minerals were coupled with ferrihydrite transformation rates, and the overall reactions were slowed down by the presence of HA that sorbed on Fe minerals.	Iron	75-77	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-48
30230819-7	2018	Our results demonstrated that the rates of As(V) speciation changes within Fe minerals were coupled with ferrihydrite transformation rates, and the overall reactions were slowed down by the presence of HA that sorbed on Fe minerals.	Iron	220-222	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-48
30230819-8	2018	Our kinetics model is able to account for variations of Fe mineral compositions, solution chemistry, and As(V) speciation, which has significant environmental implications for predicting As(V) behavior in the environment.	Iron	56-58	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	187-192
30356951-4	2018	After the treatment of beta-glucanase, the release rate of soluble Cu in corn, wheat and wheat bran, soluble Fe in barley, soybean meal and wheat bran and soluble Mn in corn and wheat bran all increased (P &lt; 0.05) compared with the control group.	Iron	109-111	beta-glucanase	Zea mays	23-37
30364139-0	2018	Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.	Iron	36-40	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
30364139-11	2018	In this review article, we describe and discuss the roles of Nrf2 in various iron-mediated bioreactions and its possible coevolution with iron and oxygen.	Iron	77-81	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
30364139-11	2018	In this review article, we describe and discuss the roles of Nrf2 in various iron-mediated bioreactions and its possible coevolution with iron and oxygen.	Iron	138-142	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
30230819-1	2018	In natural environments, kinetics of As(V) sequestration/release is usually coupled with dynamic Fe mineral transformation, which is further influenced by the presence of natural organic matter (NOM).	Iron	97-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
30230819-2	2018	Previous work mainly focused on the interactions between As(V) and Fe minerals.	Iron	67-69	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	57-62
29928945-13	2018	However, TMPRSS6 polymorphisms are associated with increased many iron-related hematological parameters.	Iron	66-70	transmembrane serine protease 6	Homo sapiens	9-16
30131336-3	2018	Whereas ablation of Ctr1 in mammals is embryonic lethal, and Ctr1 is critical for dietary Cu absorption, cardiac function, and systemic iron distribution, little is known about the intrinsic contribution of Ctr1 for Cu+ permeation through membranes or its mechanism of action.	Iron	136-140	calcitonin receptor	Homo sapiens	61-65
30131336-3	2018	Whereas ablation of Ctr1 in mammals is embryonic lethal, and Ctr1 is critical for dietary Cu absorption, cardiac function, and systemic iron distribution, little is known about the intrinsic contribution of Ctr1 for Cu+ permeation through membranes or its mechanism of action.	Iron	136-140	calcitonin receptor	Homo sapiens	61-65
30014919-8	2018	The degradation process achieved 98.2% of phenol conversion, 68.2% of mineralization and 2.11 mg L-1 of iron leaching in 150 min of reaction.	Iron	104-108	L1 cell adhesion molecule	Homo sapiens	97-100
29928945-0	2018	The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia.	Iron	37-41	transmembrane serine protease 6	Homo sapiens	12-19
29927322-5	2018	Rats fed an iron-deficient diet for 4 wk also displayed significant decrease in liver Hamp expression and liver HFE protein content.	Iron	12-16	hepcidin antimicrobial peptide	Rattus norvegicus	86-90
30301129-8	2018	Hepcidin controls dietary iron absorption and distribution in metabolic tissues, but it is unknown whether genetic variation influencing hepcidin expression modifies susceptibility to dietary iron-induced insulin resistance.	Iron	192-196	insulin	Homo sapiens	205-212
30301129-7	2018	High iron burden in adipose tissue induces insulin resistance, but the mechanisms underlying adipose iron accumulation remain unknown.	Iron	5-9	insulin	Homo sapiens	43-50
29927322-11	2018	NEW &amp; NOTEWORTHY Feeding of iron-deficient diet for 4 wk decreased liver HFE protein content in both mice and rats, suggesting that decreased HFE-dependent signaling may contribute to hepcidin downregulation in iron deficiency.	Iron	32-36	hepcidin antimicrobial peptide	Rattus norvegicus	188-196
30027360-10	2018	Tfr1, Dmt1, ferritin and ferroportin1 exist in bone tissue of rats, and they may be involved in the pathological process of iron overload-induced bone lesion.	Iron	124-128	solute carrier family 40 member 1	Rattus norvegicus	25-37
29718108-9	2018	The molecular dynamics simulations also suggested binding of LAM to the heme iron in the CYP19A1 active site.	Iron	77-81	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	89-96
30014351-7	2018	Both also induced osteoblast cell death consistent with the higher levels of cleaved caspase 3 and caspase 7 in osteoblasts, indicating that iron induced osteoblast apoptosis.	Iron	141-145	caspase 7	Rattus norvegicus	99-108
30027360-8	2018	In addition, significantly up-regulated expression of FtH and FtL mRNA, and markedly down-regulated expression of Tfr1, Dmt1 + IRE and Ireg1 mRNA, were observed in the iron overload group compared with the control group.	Iron	168-172	ferritin heavy chain 1	Rattus norvegicus	54-57
30043289-0	2018	Iron metabolism in diabetes-induced Alzheimer"s disease: a focus on insulin resistance in the brain.	Iron	0-4	insulin	Homo sapiens	68-75
30027360-8	2018	In addition, significantly up-regulated expression of FtH and FtL mRNA, and markedly down-regulated expression of Tfr1, Dmt1 + IRE and Ireg1 mRNA, were observed in the iron overload group compared with the control group.	Iron	168-172	ferritin light chain 1	Rattus norvegicus	62-65
30043289-7	2018	Iron binds to Abeta and subsequently regulates Abeta toxicity in the CNS.	Iron	0-4	amyloid beta precursor protein	Homo sapiens	14-19
30043289-8	2018	In addition, previous studies have shown that iron is involved in the aggravation of insulin resistance.	Iron	46-50	insulin	Homo sapiens	85-92
30109676-3	2018	Using a dose of 0.25 g L-1 of Fe, Cu, and Fe/Cu NPs, a degradation efficiency of 13, 26, and 43% respectively was obtained.	Iron	30-32	immunoglobulin kappa variable 1-16	Homo sapiens	23-26
29883864-3	2018	Under UV irradiation, the dissolved Fe(II) took the majority of the total dissolved Fe during the dissolution of Sch and Sch*-As(V).	Iron	36-38	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	121-131
29883864-4	2018	In the presence of oxalate, Fe(III)-oxalate complexes formed on Sch [or Sch*-As(V)] could be converted into Fe(II)-oxalate by photo-generated electrons under UV illumination, and more total dissolved Fe produced compared to that without oxalate.	Iron	28-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	72-82
30059941-1	2018	BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism.	Iron	20-24	transferrin	Homo sapiens	138-149
30059941-1	2018	BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism.	Iron	72-76	transferrin	Homo sapiens	138-149
30169597-0	2018	Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells.	Iron	0-4	WD repeat domain 45	Homo sapiens	75-80
30169597-1	2018	Beta-propeller protein-associated neurodegeneration is a subtype of monogenic neurodegeneration with brain iron accumulation caused by de novo mutations in WDR45.	Iron	107-111	WD repeat domain 45	Homo sapiens	156-161
30169597-4	2018	However, the role of WDR45 in iron homeostasis remains elusive.	Iron	30-34	WD repeat domain 45	Homo sapiens	21-26
30169597-6	2018	Our data demonstrated that loss of WDR45 increased cellular iron levels and oxidative stress, accompanied by mitochondrial abnormalities, autophagic defects, and diminished lysosomal function.	Iron	60-64	WD repeat domain 45	Homo sapiens	35-40
30169597-7	2018	Restoring WDR45 levels partially rescued oxidative stress and the susceptibility to iron treatment, and activation of autophagy reduced the observed iron overload in WDR45 mutant cells.	Iron	84-88	WD repeat domain 45	Homo sapiens	10-15
30169597-7	2018	Restoring WDR45 levels partially rescued oxidative stress and the susceptibility to iron treatment, and activation of autophagy reduced the observed iron overload in WDR45 mutant cells.	Iron	149-153	WD repeat domain 45	Homo sapiens	166-171
30169597-8	2018	Our data suggest that iron-containing macromolecules and organelles cannot effectively be degraded through the lysosomal pathway due to loss of WDR45 function.	Iron	22-26	WD repeat domain 45	Homo sapiens	144-149
30025184-3	2018	Upon formation of the M2 L3 cages, the iron corners can adopt various isomeric forms: mer, fac-Delta, or fac-Lambda.	Iron	39-43	FA complementation group C	Homo sapiens	91-94
30025184-3	2018	Upon formation of the M2 L3 cages, the iron corners can adopt various isomeric forms: mer, fac-Delta, or fac-Lambda.	Iron	39-43	FA complementation group C	Homo sapiens	105-108
30025184-5	2018	However, single cage species (fac-RR-Cage and fac-RS-Cage) that are enantiopure and highly symmetric were obtained by generating these chiral M2 L3 cages by using the bispyridine-aldehyde building blocks in combination with chiral amine moieties to form pyridylimine ligands for coordination to iron.	Iron	295-299	FA complementation group C	Homo sapiens	30-33
30025184-5	2018	However, single cage species (fac-RR-Cage and fac-RS-Cage) that are enantiopure and highly symmetric were obtained by generating these chiral M2 L3 cages by using the bispyridine-aldehyde building blocks in combination with chiral amine moieties to form pyridylimine ligands for coordination to iron.	Iron	295-299	FA complementation group C	Homo sapiens	46-49
30109676-3	2018	Using a dose of 0.25 g L-1 of Fe, Cu, and Fe/Cu NPs, a degradation efficiency of 13, 26, and 43% respectively was obtained.	Iron	42-44	immunoglobulin kappa variable 1-16	Homo sapiens	23-26
30109676-8	2018	Fe and Fe/Cu NPs showed the highest efficiency in direct black dye reductive degradation and adsorption of by-products, removing 100% of the dye at a dose of 1 g L-1 within 10 min of reaction.	Iron	0-2	immunoglobulin kappa variable 1-16	Homo sapiens	162-165
30109676-8	2018	Fe and Fe/Cu NPs showed the highest efficiency in direct black dye reductive degradation and adsorption of by-products, removing 100% of the dye at a dose of 1 g L-1 within 10 min of reaction.	Iron	7-9	immunoglobulin kappa variable 1-16	Homo sapiens	162-165
30132283-10	2018	On the other hand, at an invariable iron concentration of 5 mg Fe2+ L-1, the increase in pH was accompanied by a decrease in the molar fraction of the most photoactive iron complex (FeOH2+) and ferric hydroxides precipitation, leading to a reduction in the fluorene degradation rate.	Iron	36-40	L1 cell adhesion molecule	Homo sapiens	68-71
30029410-1	2018	Transferrin (TrF) is an important glycoprotein and disease biomarker that controls iron ion balance in the human body.	Iron	83-87	transferrin	Homo sapiens	0-11
30113655-8	2018	GPA associated with iron (p = 0.014) was detectable by MRI.	Iron	20-24	glycophorin A (MNS blood group)	Homo sapiens	0-3
30281106-0	2018	Compared with Cow Milk, a Growing-Up Milk Increases Vitamin D and Iron Status in Healthy Children at 2 Years of Age: The Growing-Up Milk-Lite (GUMLi) Randomized Controlled Trial.	Iron	66-70	Weaning weight-maternal milk	Bos taurus	37-41
30281106-0	2018	Compared with Cow Milk, a Growing-Up Milk Increases Vitamin D and Iron Status in Healthy Children at 2 Years of Age: The Growing-Up Milk-Lite (GUMLi) Randomized Controlled Trial.	Iron	66-70	Weaning weight-maternal milk	Bos taurus	37-41
30281106-2	2018	Objective: We aimed to investigate the effect of a micronutrient-fortified, reduced-energy growing-up milk (GUMLi) compared with cow milk (CM) consumed for 1 y on dietary iron and vitamin D intakes and the status of New Zealand and Australian children at 2 y of age.	Iron	171-175	Weaning weight-maternal milk	Bos taurus	102-106
30073618-7	2018	Expression analysis of these transporters supports the conclusion that Slc9a2 and Slc40a1 within the mammary gland could mediate the effect of Mmcq9 on milk Fe concentration.	Iron	157-159	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	82-89
30171894-0	2018	Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD.	Iron	92-96	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	19-23
29974467-0	2018	Drought-induced senescence of Medicago truncatula nodules involves serpin and ferritin to control proteolytic activity and iron levels.	Iron	123-127	ferritin-1, chloroplastic	Medicago truncatula	78-86
29959986-0	2018	Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells.	Iron	57-61	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
29959986-4	2018	In acute iron exposure, Nuclear factor-erythroid 2-related factor 2 (Nrf2) may protect from iron-induced injury, whereas chronic renal stress may lead to Nrf2 exhaustion.	Iron	9-13	NFE2 like bZIP transcription factor 2	Homo sapiens	24-67
29959986-4	2018	In acute iron exposure, Nuclear factor-erythroid 2-related factor 2 (Nrf2) may protect from iron-induced injury, whereas chronic renal stress may lead to Nrf2 exhaustion.	Iron	9-13	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
29959986-4	2018	In acute iron exposure, Nuclear factor-erythroid 2-related factor 2 (Nrf2) may protect from iron-induced injury, whereas chronic renal stress may lead to Nrf2 exhaustion.	Iron	92-96	NFE2 like bZIP transcription factor 2	Homo sapiens	24-67
29959986-4	2018	In acute iron exposure, Nuclear factor-erythroid 2-related factor 2 (Nrf2) may protect from iron-induced injury, whereas chronic renal stress may lead to Nrf2 exhaustion.	Iron	92-96	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
29959986-9	2018	Moreover, ferritin protein and CHOP mRNA expression were induced in combined iron and trigonelline incubated cells (p &lt; 0.05).	Iron	77-81	DNA damage inducible transcript 3	Homo sapiens	31-35
29990562-8	2018	The NADPH oxidase subunit gp91phox was increased due to iron-overload, and incubation with angiotensin II type-1 receptor (AT1) antagonist losartan not only reduced oxidative stress but also restored vascular function.	Iron	56-60	angiotensin II receptor, type 1b	Rattus norvegicus	123-126
29990562-9	2018	Thus, we concluded that AT1 pathway plays a role in pulmonary vascular dysfunction by increasing oxidative stress and reducing NO bioavailability, thereby contributing to vascular remodeling and pulmonary hypertension of iron-overload.	Iron	221-225	angiotensin II receptor, type 1b	Rattus norvegicus	24-27
30029410-1	2018	Transferrin (TrF) is an important glycoprotein and disease biomarker that controls iron ion balance in the human body.	Iron	83-87	transferrin	Homo sapiens	13-16
29990562-10	2018	This finding should instigate future studies on the beneficial impacts of in vivo blockade of AT1 receptor under iron overload.	Iron	113-117	angiotensin II receptor, type 1b	Rattus norvegicus	94-97
30295269-10	2018	CONCLUSION: Excessive oxidative stress is present in patients with HbHCS, and hepcidin is inhibited by the upregulation of EPO and sFTR, and hence involved in iron overload in patients.	Iron	159-163	erythropoietin	Homo sapiens	123-126
30203418-6	2018	Iron overload correlated with the number of preceding red blood cell transfusions and inversely correlated with circulating CD34+ cell levels (p = 0.04) at apheresis.	Iron	0-4	CD34 molecule	Homo sapiens	124-128
30183257-0	2018	Bfd, a New Class of [2Fe-2S] Protein That Functions in Bacterial Iron Homeostasis, Requires a Structural Anion Binding Site.	Iron	65-69	complement factor properdin	Homo sapiens	0-3
30323766-6	2018	Results: Leukocyte infiltration and TNF-alpha mRNA of muscle in the FE group were 5 times and 4 times greater the F group, respectively, (P &lt; 0.05).	Iron	68-70	tumor necrosis factor	Rattus norvegicus	36-45
30183257-1	2018	Mobilization of iron from bacterioferritin (BfrB) requires specific interactions with a [2Fe-2S] ferredoxin (Bfd).	Iron	16-20	complement factor properdin	Homo sapiens	109-112
30183257-2	2018	Blocking the BfrB:Bfd interaction results in irreversible iron accumulation in BfrB and iron deficiency in the cytosol [Eshelman, K., et al.	Iron	58-62	complement factor properdin	Homo sapiens	18-21
30183257-10	2018	The mutations, which caused only small changes to the strength of the BfrB:Bfd interaction and mobilization of iron from BfrB, indicate that the anion binding site in Bfd serves primarily a structural role.	Iron	111-115	complement factor properdin	Homo sapiens	167-170
30294279-5	2018	Proinflammatory cytokine, mainly IL-6, which are released by both tumor and immune cells, play a pivotal action in CRA etiopathogenesis: they promote alterations in erythroid progenitor proliferation, erythropoietin (EPO) production, survival of circulating erythrocytes, iron balance, redox status, and energy metabolism, all of which can lead to anemia.	Iron	272-276	interleukin 6	Homo sapiens	33-37
30248094-4	2018	Furthermore, we show that zebrafish Hrg1a and its paralog Hrg1b are functional heme transporters, and genetic ablation of both transporters in double knockout (DKO) animals shows lower iron accumulation concomitant with higher amounts of heme sequestered in kidney macrophages.	Iron	185-189	solute carrier family 48 member 1a	Danio rerio	58-63
30250199-0	2018	E4BP4 promotes thyroid cancer proliferation by modulating iron homeostasis through repression of hepcidin.	Iron	58-62	nuclear factor, interleukin 3 regulated	Homo sapiens	0-5
30250199-9	2018	Iron homeostasis and tumor growth in TC may be regulated by an E4BP4-dependent epigenetic mechanism.	Iron	0-4	nuclear factor, interleukin 3 regulated	Homo sapiens	63-68
30250199-10	2018	These findings suggest a new mechanism of cellular iron dysfunction through the E4BP4/G9a/SOSTDC1/hepcidin pathway, which is an essential link in TC.	Iron	51-55	nuclear factor, interleukin 3 regulated	Homo sapiens	80-85
30232287-3	2018	Human haptoglobin binds CFH with high affinity and, therefore, can potentially reduce iron availability and oxidative activity.	Iron	86-90	haptoglobin	Homo sapiens	6-17
30232287-6	2018	We found, in this S. aureus pneumonia model inducing septic shock, that commercial human haptoglobin concentrate infusions over 48-hours bind canine CFH, increase CFH clearance, and lower circulating iron.	Iron	200-204	haptoglobin	Homo sapiens	89-100
30236065-6	2018	Furthermore, serum ferritin and transferrin saturation increased in all groups (anemic [64 mug/L, 5.0%, P &lt; 0.001] iron deficient [76 mug/L, 3.6%, P &lt; 0.001]).	Iron	118-122	transferrin	Homo sapiens	32-43
30228242-7	2018	When Cth2 degradation is impaired by either mutagenesis of the Cth2 serine residues or deletion of GRR1, the levels of Cth2 rise and abrogate growth in iron-depleted conditions.	Iron	152-156	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	99-103
30148961-1	2018	FIH [factor inhibiting HIF (hypoxia inducible factor)] is an alpha-ketoglutarate (alphaKG)-dependent nonheme iron enzyme that catalyzes the hydroxylation of the C-terminal transactivation domain (CAD) asparagine residue in HIF-1alpha to regulate cellular oxygen levels.	Iron	109-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	223-233
30141807-10	2018	Our data indicate that lipin1 overexpression may cause reduction of intracellular iron content, which could activate the p53-p21-p27 signaling pathways, leading to cell cycle arrest at the G0/G1 phase in the hepatic carcinoma cells.	Iron	82-86	tumor protein p53	Homo sapiens	121-124
29990814-0	2018	EDDS enhanced PCB degradation and heavy metals stabilization in co-contaminated soils by ZVI under aerobic condition.	Iron	89-92	pyruvate carboxylase	Homo sapiens	14-17
29990814-1	2018	In the present study, biodegradable ligand EDDS was employed to assist ZVI on simultaneous remediation of PCB and heavy metals co-contaminated soils under aerobic condition.	Iron	71-74	pyruvate carboxylase	Homo sapiens	106-109
29990814-2	2018	With addition of 4 mmol L-1 EDDS and 5 g L-1 ZVI, the total removal ratio of PCB reached 75.3%, and the stabilization ratio of Pb and Cu attained 97.1% and 91.9% respectively.	Iron	45-48	pyruvate carboxylase	Homo sapiens	77-80
29990814-4	2018	Firstly, the addition of EDDS could enhance hydroxyl radical generation by ZVI and oxygen for the oxidation of PCB including distribution in the soil phase and dissolved form in the aqueous phase.	Iron	75-78	pyruvate carboxylase	Homo sapiens	111-114
29960107-4	2018	In this study, we found that JA negatively modulates iron uptake by downregulating the expression of FIT (bHLH29), bHLH38, bHLH39, bHLH100, and bHLH101 and promoting the degradation of FIT protein, a key regulator of iron uptake in Arabidopsis.	Iron	53-57	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	123-129
30021840-3	2018	We used cells lacking the mitochondrial glutaredoxin Grx5 to demonstrate that oxidant-induced cleavage formation in 25S rRNA correlates with intracellular iron levels.	Iron	155-159	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	53-57
30215387-3	2018	MATERIAL AND METHODS The Fe nanoparticles were fabricated through a one-pot reduction process under the protection of bovine serum albumin (BSA).	Iron	25-27	albumin	Homo sapiens	125-138
30254659-10	2018	Additionally, Fe-sufficient opt3-2 roots had higher "ethylene" and "GSNOR" than Fe-sufficient WT Columbia roots.	Iron	14-16	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	68-73
30254659-11	2018	The increase of both "ethylene" and "GSNOR" was not related to the total root Fe content but to the absence of a Fe shoot signal (LODIS), and was associated with the up-regulation of Fe acquisition genes.	Iron	78-80	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	37-42
30132659-5	2018	Local tensile chemical strain and increasing magnetic moments of Fe atoms on the surface of the L10 core made a dominant contribution to the enhanced NTE behavior.	Iron	65-67	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	96-99
30201907-2	2018	Plasma non-transferrin-bound iron (NTBI) is potentially harmful due to the generation of free radicals that cause tissue damage in vascular and other diseases.	Iron	29-33	transferrin	Homo sapiens	11-22
30188794-6	2018	Participants in the iron group received 250 mg of iv iron, once a month for six months, provided that their ferritin remained &lt; 300 microg/L and their transferrin saturation remained &lt; 45%.	Iron	20-24	transferrin	Homo sapiens	154-165
29298491-0	2018	Is Magnetic Resonance Imaging Detection of Kidney Iron Deposition Increased in Haptoglobin 2-2 Genotype Carriers with Type 1 Diabetes?	Iron	50-54	haptoglobin	Homo sapiens	79-90
29656314-12	2018	In conclusion, CC homozygosis in the SNP - 174 G&gt;C gene promoter of IL-6 can be proposed as one of the gene variants influencing iron accumulation in male adults with HFE mutations.	Iron	132-136	interleukin 6	Homo sapiens	71-75
29890135-2	2018	Cell death processes including apoptosis, necroptosis, cyclophilin D-(CypD)-dependent necrosis and a recently described additional form of regulated cell death called ferroptosis, are dependent on iron or iron-dependent reactive oxygen species (ROS).	Iron	197-201	peptidylprolyl isomerase F	Homo sapiens	55-68
29890135-2	2018	Cell death processes including apoptosis, necroptosis, cyclophilin D-(CypD)-dependent necrosis and a recently described additional form of regulated cell death called ferroptosis, are dependent on iron or iron-dependent reactive oxygen species (ROS).	Iron	197-201	peptidylprolyl isomerase F	Homo sapiens	70-74
29890135-2	2018	Cell death processes including apoptosis, necroptosis, cyclophilin D-(CypD)-dependent necrosis and a recently described additional form of regulated cell death called ferroptosis, are dependent on iron or iron-dependent reactive oxygen species (ROS).	Iron	205-209	peptidylprolyl isomerase F	Homo sapiens	55-68
29890135-2	2018	Cell death processes including apoptosis, necroptosis, cyclophilin D-(CypD)-dependent necrosis and a recently described additional form of regulated cell death called ferroptosis, are dependent on iron or iron-dependent reactive oxygen species (ROS).	Iron	205-209	peptidylprolyl isomerase F	Homo sapiens	70-74
29890135-7	2018	Whereas, Fe-8HQ-induced intracellular iron overload causes unregulated necrosis, but partially activates PARP-1 dependent parthanatos.	Iron	38-42	poly(ADP-ribose) polymerase 1	Homo sapiens	105-111
30250850-0	2018	The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice.	Iron	4-8	haptoglobin	Homo sapiens	88-99
29981284-0	2018	Non-transferrin-bound iron and oxidative stress during allogeneic hemopoietic stem cell transplantation in patients with or without iron overload.	Iron	22-26	transferrin	Homo sapiens	4-15
30177808-7	2018	Iron increased Caspase 9, Cytochrome c, APAF1, Caspase 3 and cleaved PARP, without affecting cleaved Caspase 8 levels.	Iron	0-4	caspase 9	Rattus norvegicus	15-24
30177808-8	2018	CBD reversed iron-induced effects, recovering apoptotic proteins Caspase 9, APAF1, Caspase 3 and cleaved PARP to the levels found in controls.	Iron	13-17	caspase 9	Rattus norvegicus	65-74
29982934-1	2018	Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance.	Iron	113-117	transferrin	Homo sapiens	0-11
29982934-1	2018	Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance.	Iron	113-117	transferrin	Homo sapiens	13-16
29982934-1	2018	Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance.	Iron	135-139	transferrin	Homo sapiens	0-11
29982934-1	2018	Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body"s iron ion channels and iron ion balance.	Iron	135-139	transferrin	Homo sapiens	13-16
29322429-0	2018	Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet".	Iron	81-85	transferrin	Homo sapiens	39-50
29859963-0	2018	Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin.	Iron	24-28	thymoma viral proto-oncogene 1	Mus musculus	92-95
29859963-7	2018	RESULTS: In vitro iron-loading of hepatocytes resulted in phosphorylation-mediated activation of Akt and AMP-activated protein kinase.	Iron	18-22	thymoma viral proto-oncogene 1	Mus musculus	97-100
29777905-9	2018	Regarding mechanism, the "reprogramming" of polyamine metabolism by iron-depletion is consistent with the down-regulation of ADI1 and MAT2alpha, and the up-regulation of SAT1.	Iron	68-72	methionine adenosyltransferase 2A	Homo sapiens	134-143
30031876-1	2018	Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN).	Iron	27-31	LYR motif containing 4	Homo sapiens	107-112
29777905-10	2018	Moreover, changes in ADI1 (biosynthetic) and SAT1 (catabolic) partially depended on the iron-regulated changes in c-Myc and/or p53.	Iron	88-92	tumor protein p53	Homo sapiens	127-130
30031876-1	2018	Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN).	Iron	27-31	iron-sulfur cluster assembly enzyme	Homo sapiens	157-161
30031876-2	2018	FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S cluster biosynthesis.	Iron	91-95	LYR motif containing 4	Homo sapiens	19-24
30031876-2	2018	FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S cluster biosynthesis.	Iron	91-95	iron-sulfur cluster assembly enzyme	Homo sapiens	29-33
30031876-4	2018	Recent studies also reported a substitution at position Met141 on the yeast ISCU orthologue Isu, to Ile, Leu, Val, or Cys, could bypass the requirement of FXN for Fe-S cluster biosynthesis and cell viability.	Iron	163-167	iron-sulfur cluster assembly enzyme	Homo sapiens	76-80
29758502-0	2018	Dual element (CCl) isotope approach to distinguish abiotic reactions of chlorinated methanes by Fe(0) and by Fe(II) on iron minerals at neutral and alkaline pH.	Iron	119-123	crystallin gamma E, pseudogene	Homo sapiens	14-17
29753286-7	2018	The amount of iron leached from SFe particles was 4.5 mg L-1, which shows that the SFe catalyst has good stability.	Iron	14-18	immunoglobulin kappa variable 1-16	Homo sapiens	57-60
30002097-1	2018	BACKGROUND: Transferrin is synthetized in the liver and is the most important iron-transport carrier in the human body.	Iron	78-82	transferrin	Homo sapiens	12-23
29991575-9	2018	Most bound to CYP3A4 via coordination to the heme iron, but several also demonstrated evidence of a distinct binding mode at low concentrations.	Iron	50-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20
30123964-10	2018	Moreover, heterologous fluorescently-labeled mammalian iron-bound transferrin is actively taken up, providing direct evidence for active iron uptake by basal endocytosis.	Iron	55-59	transferrin	Homo sapiens	66-77
30123964-10	2018	Moreover, heterologous fluorescently-labeled mammalian iron-bound transferrin is actively taken up, providing direct evidence for active iron uptake by basal endocytosis.	Iron	137-141	transferrin	Homo sapiens	66-77
29758502-0	2018	Dual element (CCl) isotope approach to distinguish abiotic reactions of chlorinated methanes by Fe(0) and by Fe(II) on iron minerals at neutral and alkaline pH.	Iron	96-98	crystallin gamma E, pseudogene	Homo sapiens	14-17
30027376-1	2018	Fe-based metal-organic framework MIL-88A microrods were synthesized by hydrothermal method, which were used to adsorb As(V) in water for the first time.	Iron	0-2	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	118-123
29782976-2	2018	The biogenesis of Fe-S clusters is orchestrated by ISC system; the sulfur donor IscS and scaffold protein IscU being its core components.	Iron	18-22	iron-sulfur cluster assembly enzyme	Homo sapiens	106-110
29860209-1	2018	Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM).	Iron	83-87	transferrin	Homo sapiens	57-68
29665075-1	2018	BACKGROUND: Transferrin is the major plasma transport protein for iron.	Iron	66-70	transferrin	Homo sapiens	12-23
29244196-9	2018	Additionally, iron overload induced G1arrest in MC3T3-E1 cells and down-regulated the expression of Cyclin D1 , Cyclin D3 , CDK2, CDK4 and CDK6, but up-regulated p27 Kip1.	Iron	14-18	cyclin-dependent kinase 4	Mus musculus	130-134
29244196-14	2018	These results show that iron overload generates ROS, blocks the PI3K/AKT and Jak/Stat3 signal pathways, and activates p38 MAPK, subsequently inducing G1 arrest and autophagy in MC3T3-E1 cells.	Iron	24-28	thymoma viral proto-oncogene 1	Mus musculus	69-72
29244196-14	2018	These results show that iron overload generates ROS, blocks the PI3K/AKT and Jak/Stat3 signal pathways, and activates p38 MAPK, subsequently inducing G1 arrest and autophagy in MC3T3-E1 cells.	Iron	24-28	signal transducer and activator of transcription 3	Mus musculus	81-86
30154413-6	2018	Additionally, IL-6 treatment was found to enhance proliferation and iron accumulation in hPASMCs; intervention with LY2928057 prevented this response.	Iron	68-72	interleukin 6	Homo sapiens	14-18
30315639-3	2018	EPO also stimulates the production of the hormone erythroferrone (ERFE) which acts to suppress hepcidin production, thus increasing dietary iron absorption and mobilizing stored iron for use in erythropoiesis.	Iron	140-144	erythroferrone	Mus musculus	66-70
30315639-3	2018	EPO also stimulates the production of the hormone erythroferrone (ERFE) which acts to suppress hepcidin production, thus increasing dietary iron absorption and mobilizing stored iron for use in erythropoiesis.	Iron	178-182	erythroferrone	Mus musculus	66-70
30154413-8	2018	Hepcidin or IL-6 mediated iron accumulation contributes to proliferation in hPASMCs; ferroportin mediated cellular iron excretion limits proliferation.	Iron	26-30	interleukin 6	Homo sapiens	12-16
30135444-2	2018	Iron-refractory iron deficiency anaemia (IRIDA), an iron metabolism disorder, is associated with mutations in the TMPRSS6 gene.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	114-121
29547281-1	2018	An iron(III) complex having a dibenzotetraethyltetraamido macrocyclic ligand (DTTM4-), (NEt4)2[FeIII(DTTM)Cl] (1), was synthesized and characterized by crystallographic, spectroscopic, and electrochemical methods.	Iron	3-7	tetraspanin 5	Homo sapiens	88-92
29807160-5	2018	Levels of iron-regulating protein such as hepcidin and ferroportin (FPN1) were examined.	Iron	10-14	hepcidin antimicrobial peptide	Rattus norvegicus	42-50
29807160-5	2018	Levels of iron-regulating protein such as hepcidin and ferroportin (FPN1) were examined.	Iron	10-14	solute carrier family 40 member 1	Rattus norvegicus	68-72
29807160-8	2018	Furthermore, L-LYC suppressed hepcidin-mediated decrease in FPN1, a sole iron exporter, and normalized the levels of iron.	Iron	73-77	hepcidin antimicrobial peptide	Rattus norvegicus	30-38
29807160-8	2018	Furthermore, L-LYC suppressed hepcidin-mediated decrease in FPN1, a sole iron exporter, and normalized the levels of iron.	Iron	117-121	hepcidin antimicrobial peptide	Rattus norvegicus	30-38
30100261-4	2018	PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, which leads to the HIF1A-dependent Warburg effect and AIM2-dependent inflammasome activation in tumor cells.	Iron	90-94	solute carrier family 25, member 37	Mus musculus	44-52
30100261-4	2018	PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, which leads to the HIF1A-dependent Warburg effect and AIM2-dependent inflammasome activation in tumor cells.	Iron	90-94	solute carrier family 25, member 28	Mus musculus	57-65
30135444-1	2018	TMPRSS6, also known as matriptase-2, is a type II transmembrane serine protease that plays a major role in iron homeostasis by acting as a negative regulator of hepcidin production through cleavage of the BMP co-receptor haemojuvelin.	Iron	107-111	transmembrane serine protease 6	Homo sapiens	0-7
30135444-1	2018	TMPRSS6, also known as matriptase-2, is a type II transmembrane serine protease that plays a major role in iron homeostasis by acting as a negative regulator of hepcidin production through cleavage of the BMP co-receptor haemojuvelin.	Iron	107-111	transmembrane serine protease 6	Homo sapiens	23-35
30028454-1	2018	The Fe(TPA) (TPA = tris(pyridyl-2-methyl)amine) class of non-haem Fe catalysts is proposed to carry out selective hydrocarbon oxidations through the generation of high-valent iron species.	Iron	4-6	plasminogen activator, tissue type	Homo sapiens	7-10
30110365-4	2018	We found that a specific endogenous metabolite of vitamin E, alpha-tocopherol hydroquinone, was a dramatically more potent inhibitor of ferroptosis than its parent compound, and inhibits 15-lipoxygenase via reduction of the enzyme"s non-heme iron from its active Fe3+ state to an inactive Fe2+ state.	Iron	242-246	arachidonate 15-lipoxygenase	Homo sapiens	187-202
30028454-1	2018	The Fe(TPA) (TPA = tris(pyridyl-2-methyl)amine) class of non-haem Fe catalysts is proposed to carry out selective hydrocarbon oxidations through the generation of high-valent iron species.	Iron	175-179	plasminogen activator, tissue type	Homo sapiens	4-11
30028454-1	2018	The Fe(TPA) (TPA = tris(pyridyl-2-methyl)amine) class of non-haem Fe catalysts is proposed to carry out selective hydrocarbon oxidations through the generation of high-valent iron species.	Iron	175-179	plasminogen activator, tissue type	Homo sapiens	7-10
29546482-5	2018	In this study, we aimed to understand the roles of bHLH38, bHLH39, bHLH100 and bHLH101 genes for Fe homeostasis in Arabidopsis, tomato, rice, soybean and maize species by using bioinformatics approaches.	Iron	97-99	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	59-65
29995418-5	2018	The increased amounts of therapeutic growth factors inside NV-IONP were attributed to IONPs that are slowly ionized to iron ions which activate the JNK and c-Jun signaling cascades in hMSCs.	Iron	119-123	mitogen-activated protein kinase 8	Homo sapiens	148-151
29983374-1	2018	Cysteine desulfurase plays a central role in mitochondrial iron-sulfur cluster biogenesis by generating sulfur through the conversion of L-cysteine to L-alanine and by serving as the platform for assembling other components of the biosynthetic machinery, including ISCU, frataxin, and ferredoxin.	Iron	59-63	iron-sulfur cluster assembly enzyme	Homo sapiens	265-269
29893871-3	2018	Prevention of NtPDR3 expression resulted in N. tabacum plants that were less tolerant to iron-deficient conditions, displaying stronger chlorosis and slower growth than those of the wild-type when not supplied with iron.	Iron	89-93	pleiotropic drug resistance protein 3	Nicotiana tabacum	14-20
29893871-3	2018	Prevention of NtPDR3 expression resulted in N. tabacum plants that were less tolerant to iron-deficient conditions, displaying stronger chlorosis and slower growth than those of the wild-type when not supplied with iron.	Iron	215-219	pleiotropic drug resistance protein 3	Nicotiana tabacum	14-20
29914989-7	2018	Transcriptomic studies indicated that loss of the ompR gene affects the expression of 701 genes, many associated with outer membrane composition, motility, stress response, iron acquisition, and the uptake of nutrients, consistent with starvation tolerance.	Iron	173-177	ompR	Burkholderia multivorans	50-54
30371224-12	2018	Conclusions The authors recommend avoiding a low hemoglobin level and maintaining serum ferritin between 300 and 800 ng/mL and transferrin saturation between 30% and 50%, which were associated with lower risks of all-cause mortality among patients undergoing hemodialysis receiving the restricted erythropoiesis-stimulating agent doses but prompt intravenous iron supplementation in Taiwan.	Iron	359-363	transferrin	Homo sapiens	127-138
30155291-11	2018	A statistically significant difference was found only in MCH when the erythrocyte parameters and iron status indicators values of the cases in glaucoma patients were compared with the glaucoma duration (p&lt;0.05).	Iron	97-101	pro-melanin concentrating hormone	Homo sapiens	57-60
29623474-0	2018	Effects of iron on the aggregation propensity of the N-terminal fibrillogenic polypeptide of human apolipoprotein A-I.	Iron	11-15	apolipoprotein A1	Homo sapiens	99-117
29623474-6	2018	As the main effect of iron deregulation is proposed to be an increase in oxidative stress, we analysed the effects of iron on [1-93]ApoA-I aggregation.	Iron	118-122	apolipoprotein A1	Homo sapiens	132-138
29730778-2	2018	Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism.	Iron	23-27	interleukin 6	Mus musculus	71-75
29773554-10	2018	In addition, potassium ferricyanide prevented the enzyme from the inactivation mediated by NC, which provided evidence that inhibition of CYP2D6 resulted from heme destruction by the formation of a carbene-iron complex.	Iron	206-210	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	138-144
29730778-2	2018	Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism.	Iron	189-193	interleukin 6	Mus musculus	71-75
29730778-8	2018	Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes.	Iron	48-50	interleukin 6	Mus musculus	207-211
29730778-8	2018	Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes.	Iron	48-50	tumor necrosis factor	Mus musculus	213-222
29730778-8	2018	Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes.	Iron	48-50	mast cell protease 1	Mus musculus	224-229
30071596-6	2018	Mouse microglia grown in high iron concentrations showed many characteristics of dystrophic microglia including, increased iron storage, increased expression of proteins, such as ferritin and the potassium channel, Kv1.3, increased reactive oxygen species production and cytokine release.	Iron	30-34	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	215-220
29702192-6	2018	Mechanistically, PAB improved intracellular iron by upregulation of transferrin receptor.	Iron	44-48	transferrin	Homo sapiens	68-79
29856995-11	2018	Partial unfolding of CytC in the complex was evidenced by (a) appearance of fluorescence of tyrosine and tryptophan residues and (b) disappearance of the absorption band at 699 nm due to breakdown of heme iron - methionine bond &gt; F S(Met80).	Iron	205-209	cytochrome c, somatic	Homo sapiens	21-25
29572975-9	2018	Gene expression of nuclear factor, erythroid-derived 2-like 2 (Nrf2) and zonula occludens-1 (ZO-1), in the higher dietary Fe groups was enhanced (p &lt; .05).	Iron	122-124	NFE2 like bZIP transcription factor 2	Homo sapiens	19-61
30154939-8	2018	Carriers of the MPO variant allele had decreased WBC, neutrophil, eosinophil, basophil, monocyte, lymphocyte, and platelet counts and an elevated free iron level.	Iron	151-155	myeloperoxidase	Homo sapiens	16-19
29172713-3	2018	The aim of the present study was to determine whether treatment of cardiotoxicity with iron chelators (deferiprone (DFP) or deferoxamine (DFO)) alone or in combination with phytochemical activation of Nrf2 (green tea) can protect cardiomyocytes from IONR overload-induced cardiotoxicity.	Iron	87-91	NFE2 like bZIP transcription factor 2	Rattus norvegicus	201-205
29766365-9	2018	However, CPZ administration to rats treated sub-chronically with Fe showed increased brain CAT activity after 2 or 4 h, as compared to control values.	Iron	65-67	catalase	Rattus norvegicus	91-94
29966105-3	2018	Excess iron in the form of non-transferrin-bound iron (NTBI) causes injury and is readily uptaken by cardiomyocytes, pancreatic islet cells, and hepatocytes.	Iron	7-11	transferrin	Homo sapiens	31-42
29966105-3	2018	Excess iron in the form of non-transferrin-bound iron (NTBI) causes injury and is readily uptaken by cardiomyocytes, pancreatic islet cells, and hepatocytes.	Iron	49-53	transferrin	Homo sapiens	31-42
29926339-9	2018	CD4+CD28null T lymphocytes were positively correlated to transfusional iron input while these cells and IFN-gamma were negatively correlated to cardiac T2* and duration of hydroxyurea therapy.	Iron	71-75	CD4 molecule	Homo sapiens	0-3
29572975-9	2018	Gene expression of nuclear factor, erythroid-derived 2-like 2 (Nrf2) and zonula occludens-1 (ZO-1), in the higher dietary Fe groups was enhanced (p &lt; .05).	Iron	122-124	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
29572975-9	2018	Gene expression of nuclear factor, erythroid-derived 2-like 2 (Nrf2) and zonula occludens-1 (ZO-1), in the higher dietary Fe groups was enhanced (p &lt; .05).	Iron	122-124	tight junction protein 1	Homo sapiens	73-91
29572975-9	2018	Gene expression of nuclear factor, erythroid-derived 2-like 2 (Nrf2) and zonula occludens-1 (ZO-1), in the higher dietary Fe groups was enhanced (p &lt; .05).	Iron	122-124	tight junction protein 1	Homo sapiens	93-97
29331081-12	2018	The fraction of the initial iron dose that was taken up by PSMA-positive tumors was 2.32 +- 0.75% (n = 10); uptake by the PSMA-negative DU145 tumors and for SPIONs without anti-PSMA antibodies was 0.16 +- 0.34% (n = 7) giving a ratio of [Fe] in PSMA + versus PSMA- tumors greater than 15:1 (P = 0.01).	Iron	28-32	folate hydrolase 1	Homo sapiens	59-63
29331081-2	2018	PURPOSE: To apply our newly developed [Fe]MRI method to the quantitative imaging in both space and time of the iron dynamics of anti-prostate specific membrane antigen (PSMA) conjugated SPIONs within human prostate tumor xenografts in nude mice.	Iron	39-41	folate hydrolase 1	Homo sapiens	128-167
29614421-0	2018	Tuning the morphology and Fe/Ni ratio of a bimetallic Fe-Ni-S film supported on nickel foam for optimized electrolytic water splitting.	Iron	26-28	solute carrier family 5 member 5	Homo sapiens	57-61
29331081-2	2018	PURPOSE: To apply our newly developed [Fe]MRI method to the quantitative imaging in both space and time of the iron dynamics of anti-prostate specific membrane antigen (PSMA) conjugated SPIONs within human prostate tumor xenografts in nude mice.	Iron	39-41	folate hydrolase 1	Homo sapiens	169-173
29851359-0	2018	Insulin Resistance and Metabolic Syndrome: Clinical and Laboratory Associations in African Americans Without Diabetes in the Hemochromatosis and Iron Overload Screening Study.	Iron	145-149	insulin	Homo sapiens	0-7
29331081-2	2018	PURPOSE: To apply our newly developed [Fe]MRI method to the quantitative imaging in both space and time of the iron dynamics of anti-prostate specific membrane antigen (PSMA) conjugated SPIONs within human prostate tumor xenografts in nude mice.	Iron	111-115	folate hydrolase 1	Homo sapiens	128-167
29331081-2	2018	PURPOSE: To apply our newly developed [Fe]MRI method to the quantitative imaging in both space and time of the iron dynamics of anti-prostate specific membrane antigen (PSMA) conjugated SPIONs within human prostate tumor xenografts in nude mice.	Iron	111-115	folate hydrolase 1	Homo sapiens	169-173
29331081-9	2018	The iron taken up by PSMA-positive LNCaP and C4-2 tumors was proportional to the tail-vein injected dose from 60 nmol to 1.6 mumol; injection of 1 mumol of iron in anti-PSMA conjugated SPIONs resulted in a tumor [Fe] of 76 muM.	Iron	4-8	folate hydrolase 1	Homo sapiens	21-25
29331081-9	2018	The iron taken up by PSMA-positive LNCaP and C4-2 tumors was proportional to the tail-vein injected dose from 60 nmol to 1.6 mumol; injection of 1 mumol of iron in anti-PSMA conjugated SPIONs resulted in a tumor [Fe] of 76 muM.	Iron	4-8	folate hydrolase 1	Homo sapiens	169-173
29331081-9	2018	The iron taken up by PSMA-positive LNCaP and C4-2 tumors was proportional to the tail-vein injected dose from 60 nmol to 1.6 mumol; injection of 1 mumol of iron in anti-PSMA conjugated SPIONs resulted in a tumor [Fe] of 76 muM.	Iron	156-160	folate hydrolase 1	Homo sapiens	21-25
29331081-9	2018	The iron taken up by PSMA-positive LNCaP and C4-2 tumors was proportional to the tail-vein injected dose from 60 nmol to 1.6 mumol; injection of 1 mumol of iron in anti-PSMA conjugated SPIONs resulted in a tumor [Fe] of 76 muM.	Iron	156-160	folate hydrolase 1	Homo sapiens	169-173
29331081-9	2018	The iron taken up by PSMA-positive LNCaP and C4-2 tumors was proportional to the tail-vein injected dose from 60 nmol to 1.6 mumol; injection of 1 mumol of iron in anti-PSMA conjugated SPIONs resulted in a tumor [Fe] of 76 muM.	Iron	213-215	folate hydrolase 1	Homo sapiens	21-25
29799319-1	2018	The transcription factor Nrf2 is an important modulator of antioxidant and drug metabolism, carbohydrate and lipid metabolism, as well as heme and iron metabolism.	Iron	147-151	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
29995317-8	2018	Hog1p, a MAP kinase involved in stress responses, also negatively regulates iron uptake by phosphorylating Aft1p.	Iron	76-80	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	0-5
29524892-0	2018	A novel method of simultaneous NH4+ and NO3- removal using Fe cycling as a catalyst: Feammox coupled with NAFO.	Iron	59-61	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
29524892-1	2018	The feasibility of using Feammox coupled with nitrate-dependent Fe(II) oxidizing (NAFO) to cause the simultaneous conversion of NH4+ and NO3- was explored by inoculation with Feammox sludge and the use Fe cycling as catalyst.	Iron	25-27	NBL1, DAN family BMP antagonist	Homo sapiens	137-140
29524892-5	2018	The results showed the simultaneous continuous conversion process of NO3- and NH4+ with limited Fe as a catalyst was a coupled process of Feammox, Anammox, and NAFO under the anaerobic conditions.	Iron	96-98	NBL1, DAN family BMP antagonist	Homo sapiens	69-72
29957993-3	2018	Several facts are now established: the presence of large amount of d-block (M) ions (Zn, Cu, and Fe) in the aggregated forms; the 1:1 M/Abeta ratio favors the formation of amorphous aggregates, with an aggregation rate lower than that in the absence of such ions.	Iron	97-99	amyloid beta precursor protein	Homo sapiens	136-141
29877528-6	2018	This value, close to that of transferrin with iron, evidenced the high affinity of the protein for thorium.	Iron	46-50	transferrin	Homo sapiens	29-40
29776461-0	2018	Soybean Peroxidase-Catalyzed Treatment of Azo Dyes with or without Fe  Pretreatment.	Iron	67-69	peroxidase	Glycine max	8-18
30960711-0	2018	Novel PSMA-Coated On-Off-On Fluorescent Chemosensor Based on Organic Dots with AIEgens for Detection of Copper (II), Iron (III) and Cysteine.	Iron	117-121	folate hydrolase 1	Homo sapiens	6-10
29958803-0	2018	Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.	Iron	0-4	poly(rC) binding protein 1	Homo sapiens	73-78
29958803-2	2018	Here we showed that iron promoted proinflammatory cytokine expression in T cells, including GM-CSF and IL-2, via regulating the stability of an RNA-binding protein PCBP1.	Iron	20-24	interleukin 2	Homo sapiens	103-107
29958803-2	2018	Here we showed that iron promoted proinflammatory cytokine expression in T cells, including GM-CSF and IL-2, via regulating the stability of an RNA-binding protein PCBP1.	Iron	20-24	poly(rC) binding protein 1	Homo sapiens	164-169
29958803-5	2018	Mechanistically, intracellular iron protected PCBP1 protein from caspase-mediated proteolysis, and PCBP1 promoted messenger RNA stability of Csf2 and Il2 by recognizing UC-rich elements in the 3" UTRs.	Iron	31-35	poly(rC) binding protein 1	Homo sapiens	46-51
29395830-3	2018	Labile plasma iron (LPI, the redox-active component of non-transferrin bound iron) has been studied as an indicator of systemic iron overload and of chelation efficacy, and may particularly reflect recent iron equilibrium.	Iron	14-18	transferrin	Homo sapiens	59-70
29688240-3	2018	To test the hypothesis that increased chemical reduction of iron, as observed in vitro in the presence of aggregating amyloid-beta, may occur at sites of amyloid plaque formation in the human brain, the nanoscale distribution and physicochemical states of biometals, particularly iron, were characterised in isolated amyloid plaque cores from human Alzheimer"s disease cases using synchrotron X-ray spectromicroscopy.	Iron	60-64	amyloid beta precursor protein	Homo sapiens	118-130
30042723-0	2018	Heterozygous PLA2G6 Mutation Leads to Iron Accumulation Within Basal Ganglia and Parkinson"s Disease.	Iron	38-42	phospholipase A2 group VI	Homo sapiens	13-19
29977030-3	2018	We hypothesized that PBC patients would exhibit reduced volume and increased iron deposition of the hippocampus.	Iron	77-81	dihydrolipoamide S-acetyltransferase	Homo sapiens	21-24
29980709-6	2018	Increased liver iron correlated with circulatory iron, TNF-alpha, macrophage activation (sCD163) and peroxide-stress in CD163+macrophages in patients who were iron-overloaded and died.	Iron	16-20	tumor necrosis factor	Homo sapiens	55-64
29980709-10	2018	These results suggest that iron mediates inflammation through ADAM17 induction, resulting in macrophage activation and increased shedding of TNF-alpha and sCD163.	Iron	27-31	tumor necrosis factor	Homo sapiens	141-150
28882065-10	2018	Approximately 9.7% of the variation in serum high-sensitive C-reactive protein in diabetic non-hypertensive patients could be explained by body mass index, and intake of sodium, iron and cholesterol.	Iron	178-182	C-reactive protein	Homo sapiens	60-78
29599085-2	2018	Congenital dyserythropoietic anemia type I (CDA1) can present in utero with hydrops fetalis, but more often it presents in childhood or adulthood with moderate macrocytic anemia, jaundice, and progressive iron-overload.	Iron	205-209	codanin 1	Homo sapiens	0-42
29599085-2	2018	Congenital dyserythropoietic anemia type I (CDA1) can present in utero with hydrops fetalis, but more often it presents in childhood or adulthood with moderate macrocytic anemia, jaundice, and progressive iron-overload.	Iron	205-209	codanin 1	Homo sapiens	44-48
29916839-1	2018	PLA2G6-associated neurodegeneration is a major subtype of neurodegeneration with brain iron accumulation.	Iron	87-91	phospholipase A2 group VI	Homo sapiens	0-6
30146840-9	2018	In iron overload thalassemia groups, expression levels of erythropoietin and ferritin were increased, but hepcidin and transferrin were significantly reduced.	Iron	3-7	erythropoietin	Homo sapiens	58-72
30146840-9	2018	In iron overload thalassemia groups, expression levels of erythropoietin and ferritin were increased, but hepcidin and transferrin were significantly reduced.	Iron	3-7	transferrin	Homo sapiens	119-130
29452568-7	2018	Validation by quantitative real-time PCR revealed that only the expression of transferrin receptor, which is involved in iron transport; and tribbles pseudokinase 3, which is involved in insulin signaling, were unequivocally regulated by primary cilia sensing of fluid flow.	Iron	121-125	transferrin	Homo sapiens	78-89
29777745-1	2018	AIMS: Body iron inhibits the metabolism of adiponectin, an insulin sensitizing adipokine.	Iron	11-15	adiponectin, C1Q and collagen domain containing	Homo sapiens	43-54
29377263-12	2018	The elevated hepatic hepcidin decreased FPN1 levels in the spleen, likely causing the increased iron accumulation in the spleen.	Iron	96-100	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	40-44
29848660-0	2018	Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis.	Iron	0-4	kinesin family member 4A	Homo sapiens	47-52
29689452-0	2018	Role of the HSPA9/HSC20 chaperone pair in promoting directional human iron-sulfur cluster exchange involving monothiol glutaredoxin 5.	Iron	70-74	heat shock protein family A (Hsp70) member 9	Homo sapiens	12-17
29689452-3	2018	In eukaryotes a [2Fe-2S] cluster is first assembled in the mitochondria on the iron-sulfur cluster scaffold protein ISCU in tandem with iron, sulfide, and electron donors.	Iron	79-83	iron-sulfur cluster assembly enzyme	Homo sapiens	116-120
29689452-3	2018	In eukaryotes a [2Fe-2S] cluster is first assembled in the mitochondria on the iron-sulfur cluster scaffold protein ISCU in tandem with iron, sulfide, and electron donors.	Iron	136-140	iron-sulfur cluster assembly enzyme	Homo sapiens	116-120
29857891-21	2018	Therefore, by specifically designing a diet to combine dietary sources with high content of both iron and vitamin B12 could result with a cumulative effect: the cytoprotective effect of vitamin B12, and diminished negative effect of high iron content in the feces.	Iron	97-101	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	194-197
29857891-21	2018	Therefore, by specifically designing a diet to combine dietary sources with high content of both iron and vitamin B12 could result with a cumulative effect: the cytoprotective effect of vitamin B12, and diminished negative effect of high iron content in the feces.	Iron	238-242	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	114-117
29857891-22	2018	Clarifying the relevance of various dietary sources of iron from the aspect of high vitamin B12 content might provide answers we are still missing in the CRC.	Iron	55-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	92-95
29703633-7	2018	RESULTS: Iron supplementation significantly increased hemoglobin, mean corpuscular volume, ferritin, and transferrin saturation rate, and decreased erythropoiesis-stimulating agent dose and erythropoiesis-stimulating agent resistance index value.	Iron	9-13	transferrin	Homo sapiens	105-116
29848660-7	2018	KIF4A binds a Fe-S cluster in vitro through its conserved cysteine-rich domain.	Iron	14-18	kinesin family member 4A	Homo sapiens	0-5
29848660-10	2018	These findings suggest that the lack of Fe-S clusters in KIF4A upon downregulation of the CIA targeting complex contributes to the mitotic defects.	Iron	40-44	kinesin family member 4A	Homo sapiens	57-62
29988966-8	2018	Moreover, iron treatment partially rescued CCA-mediated AR repression.	Iron	10-14	androgen receptor	Homo sapiens	56-58
29988966-10	2018	We propose a new V-ATPase-dependent mechanism to inhibit androgen receptor expression in prostate cancer cells involving defective endosomal trafficking of iron and the inhibition of HIF-1 alpha-subunit turnover.	Iron	156-160	androgen receptor	Homo sapiens	57-74
29872820-6	2018	Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin.	Iron	43-47	tumor protein p53	Homo sapiens	79-82
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Iron	103-107	spinster	Drosophila melanogaster	183-187
29724825-6	2018	In vitro studies revealed that the elevated intracellular iron promoted macrophage proliferation and amplified expression of nuclear factor of activated T cells 1 (Nfatc1) and PPARG coactivator 1beta (Pgc-1beta), two transcription factors critical for osteoclast differentiation.	Iron	58-62	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	125-162
29724825-6	2018	In vitro studies revealed that the elevated intracellular iron promoted macrophage proliferation and amplified expression of nuclear factor of activated T cells 1 (Nfatc1) and PPARG coactivator 1beta (Pgc-1beta), two transcription factors critical for osteoclast differentiation.	Iron	58-62	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	164-170
29724825-6	2018	In vitro studies revealed that the elevated intracellular iron promoted macrophage proliferation and amplified expression of nuclear factor of activated T cells 1 (Nfatc1) and PPARG coactivator 1beta (Pgc-1beta), two transcription factors critical for osteoclast differentiation.	Iron	58-62	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	201-210
29790346-0	2018	Ligand-Free Iron-Catalyzed Carbon(sp2)-Carbon(sp2) Cross-Coupling of Alkenyllithium with Vinyl Halides.	Iron	12-16	Sp2 transcription factor	Homo sapiens	34-37
29873371-6	2018	Although the optimized differential spin density of states at the Fermi level (SDOS) of the kinked carbon chains is higher than that of bulk Fe, the magnetic moment is as low as 0.3muB.	Iron	66-68	nudix hydrolase 16 like 1	Homo sapiens	79-83
29695420-17	2018	The results also provide a solid basis for further investigations of the role of USP24 in regulating iron metabolism during infection and other diseases.	Iron	101-105	ubiquitin specific peptidase 24	Homo sapiens	81-86
29808889-1	2018	Blood contains a poorly characterized pool of labile iron called non-transferrin-bound iron (NTBI).	Iron	53-57	transferrin	Homo sapiens	69-80
29808889-1	2018	Blood contains a poorly characterized pool of labile iron called non-transferrin-bound iron (NTBI).	Iron	87-91	transferrin	Homo sapiens	69-80
29808889-13	2018	Some FTS iron adsorbed onto the column, especially at higher pH.	Iron	9-13	AKT interacting protein	Homo sapiens	5-8
29808889-14	2018	Column-adsorbing-iron coordinated apo-transferrin whereas the more tightly coordinated iron species did not.	Iron	17-21	transferrin	Homo sapiens	38-49
29790346-0	2018	Ligand-Free Iron-Catalyzed Carbon(sp2)-Carbon(sp2) Cross-Coupling of Alkenyllithium with Vinyl Halides.	Iron	12-16	Sp2 transcription factor	Homo sapiens	46-49
29845135-1	2018	The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the intrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin-orbit couplings.	Iron	103-107	spinster	Drosophila melanogaster	252-256
30110405-3	2018	PCB dechlorination and removal efficiencies after 4 h at 250 C and in the presence of iron were 97.4% and 99.8%, respectively.	Iron	86-90	pyruvate carboxylase	Homo sapiens	0-3
29889872-4	2018	We report that, compared to the natural iron delivery proteins, transferrin and H-ferritin, the pharmaceutical iron formulations neither cross the blood-brain barrier model nor significantly load the endothelial cells with iron.	Iron	111-115	transferrin	Homo sapiens	64-75
29889872-4	2018	We report that, compared to the natural iron delivery proteins, transferrin and H-ferritin, the pharmaceutical iron formulations neither cross the blood-brain barrier model nor significantly load the endothelial cells with iron.	Iron	111-115	transferrin	Homo sapiens	64-75
29529562-0	2018	Application of sequential extraction analysis to Pb(II) recovery by zerovalent iron-based particles.	Iron	79-83	submaxillary gland androgen regulated protein 3B	Homo sapiens	49-55
29529562-4	2018	At high initial Pb(II) concentration (500 mg L-1), more than 99.5% of Pb(II) was immobilized by Ni/Fe and n-ZVI, whereas m-ZVI caused inferior recovery efficiency (&lt;25%).	Iron	99-101	submaxillary gland androgen regulated protein 3B	Homo sapiens	70-76
29529562-8	2018	The reactivity of ZVI toward Pb(II) followed the increasing order of m-ZVI &lt;&lt; n-ZVI &lt;= Ni/Fe.	Iron	18-21	submaxillary gland androgen regulated protein 3B	Homo sapiens	29-35
29529562-8	2018	The reactivity of ZVI toward Pb(II) followed the increasing order of m-ZVI &lt;&lt; n-ZVI &lt;= Ni/Fe.	Iron	71-74	submaxillary gland androgen regulated protein 3B	Homo sapiens	29-35
29529562-8	2018	The reactivity of ZVI toward Pb(II) followed the increasing order of m-ZVI &lt;&lt; n-ZVI &lt;= Ni/Fe.	Iron	99-101	submaxillary gland androgen regulated protein 3B	Homo sapiens	29-35
29529562-9	2018	The detailed mechanisms of Pb(II) recovery conducted by different ZVI were proposed.	Iron	66-69	submaxillary gland androgen regulated protein 3B	Homo sapiens	27-33
29529562-5	2018	XRD and XPS results revealed that Pb(II) was reduced to Pb0 prior to the formation of metal hydroxides as the external shell of ZVI.	Iron	128-131	submaxillary gland androgen regulated protein 3B	Homo sapiens	34-40
29874829-5	2018	It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN).	Iron	21-25	transferrin	Homo sapiens	122-133
29529562-7	2018	Consequently, (co-)precipitation and specific adsorption dominated Pb(II) recovery by Ni/Fe and n-ZVI, whereas m-ZVI conducted Pb(II) recovery mainly via weak adsorption.	Iron	89-91	submaxillary gland androgen regulated protein 3B	Homo sapiens	67-73
29672865-0	2018	Dietary Iron Fortification Normalizes Fetal Hematology, Hepcidin, and Iron Distribution in a Rat Model of Prenatal Alcohol Exposure.	Iron	8-12	hepcidin antimicrobial peptide	Rattus norvegicus	56-64
29672865-11	2018	Iron fortification also normalized hepcidin expression in alcohol-exposed maternal and fetal liver.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	35-43
30034931-4	2018	In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron.	Iron	12-16	transferrin	Homo sapiens	102-113
30034931-4	2018	In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron.	Iron	12-16	transferrin	Homo sapiens	115-117
30034931-4	2018	In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron.	Iron	83-87	transferrin	Homo sapiens	102-113
30034931-4	2018	In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron.	Iron	83-87	transferrin	Homo sapiens	115-117
30034931-6	2018	During the iron intake process in generic cells, transferrin receptors (TFRs) act as the most important receptor mediated controls.	Iron	11-15	transferrin	Homo sapiens	49-60
30034931-7	2018	TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells.	Iron	55-59	transferrin	Homo sapiens	60-71
30034931-7	2018	TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells.	Iron	94-98	transferrin	Homo sapiens	60-71
29748743-14	2018	Confocal microscopy revealed nuclear translocation of Nrf2 (the key event in Keap1/Nrf2 signaling) induced by apo-rhLF (iron-free, RPMI-1640).	Iron	120-124	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
29748743-14	2018	Confocal microscopy revealed nuclear translocation of Nrf2 (the key event in Keap1/Nrf2 signaling) induced by apo-rhLF (iron-free, RPMI-1640).	Iron	120-124	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
29767396-1	2018	A number of important Gram-negative pathogens that reside exclusively in the upper respiratory or genitourinary tract of their mammalian host rely on surface receptors that specifically bind host transferrin and lactoferrin as a source of iron for growth.	Iron	239-243	transferrin	Homo sapiens	196-207
29767396-2	2018	The transferrin receptors have been targeted for vaccine development due to their critical role in acquiring iron during invasive infection and for survival on the mucosal surface.	Iron	109-113	transferrin	Homo sapiens	4-15
29672865-14	2018	In PAE, hepcidin levels were linearly related to increased liver iron stores and decreased red blood cell count and brain iron.	Iron	65-69	hepcidin antimicrobial peptide	Rattus norvegicus	8-16
29672865-14	2018	In PAE, hepcidin levels were linearly related to increased liver iron stores and decreased red blood cell count and brain iron.	Iron	122-126	hepcidin antimicrobial peptide	Rattus norvegicus	8-16
29672865-15	2018	CONCLUSIONS: Maternal oral iron fortification mitigated PAE"s disruption of fetal iron homeostasis and improved brain iron content, hematologic indices, and hepcidin production in this rat PAE model.	Iron	27-31	hepcidin antimicrobial peptide	Rattus norvegicus	157-165
29501031-6	2018	The iron content in ANAMMOX biofilm presented linear correlation with the influent Fe (II) in 1-20 mg L-1, which then tended to be stable when Fe (II) was higher.	Iron	4-8	immunoglobulin kappa variable 1-16	Homo sapiens	102-105
29344709-11	2018	This paper indicates the relevant role of iron-reducing organisms and Chloroflexi, Geobacteraceae, and Firmicutes group in PCB metabolism.	Iron	42-46	pyruvate carboxylase	Homo sapiens	123-126
29543340-0	2018	PlGF and sFlt-1 levels in patients with non-transfusion-dependent thalassemia: Correlations with markers of iron burden and endothelial dysfunction.	Iron	108-112	placental growth factor	Homo sapiens	0-4
29543340-7	2018	CONCLUSIONS: In this study, we demonstrated an association between increased PlGF and iron overload and the degree of tissue hypoxia in patients with NTDT.	Iron	86-90	placental growth factor	Homo sapiens	77-81
29380428-2	2018	The aim of this study was to observe the impact of diabetic lipid and glucose patterns on the correlation between FE LDL-C (F-LDL) and ET LDL-C (E-LDL) in patients with coronary artery disease (CAD).	Iron	114-116	component of oligomeric golgi complex 2	Homo sapiens	117-122
29380557-0	2018	hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway.	Iron	44-48	AKT serine/threonine kinase 1	Homo sapiens	89-92
29380557-3	2018	We hypothesize that an impaired Akt-FOXO3a signalling pathway triggers changes in the iron metabolism in the muscles of transgenic animals.	Iron	86-90	AKT serine/threonine kinase 1	Homo sapiens	32-35
29380557-11	2018	In SH-SY5Y cells stably expressing SOD1 or SOD1 G93A, we observed elevated levels of ferritin L and H and non-haem iron.	Iron	115-119	superoxide dismutase 1	Homo sapiens	35-39
29380557-11	2018	In SH-SY5Y cells stably expressing SOD1 or SOD1 G93A, we observed elevated levels of ferritin L and H and non-haem iron.	Iron	115-119	superoxide dismutase 1	Homo sapiens	43-47
29380557-16	2018	CONCLUSIONS: Our data suggest that impairment of insulin signalling and iron metabolism in the skeletal muscle precedes muscle atrophy and is mediated by changes in Akt/FOXO3a signalling pathways.	Iron	72-76	AKT serine/threonine kinase 1	Homo sapiens	165-168
29380557-16	2018	CONCLUSIONS: Our data suggest that impairment of insulin signalling and iron metabolism in the skeletal muscle precedes muscle atrophy and is mediated by changes in Akt/FOXO3a signalling pathways.	Iron	72-76	forkhead box O3	Homo sapiens	169-175
30961459-10	2018	In addition, both H2O2 and TNFalpha significantly (P &lt; 0.05) upregulated hepcidin expression and marginally reduced ferroportin (Fpn) expression unlike iron treatment alone.	Iron	155-159	tumor necrosis factor	Homo sapiens	27-35
29575577-7	2018	We found that Smad6 and Bambi-but not Follistatin-are controlled by the iron-BMP-Smad pathway.	Iron	72-76	BMP and activin membrane-bound inhibitor	Mus musculus	24-29
29380428-2	2018	The aim of this study was to observe the impact of diabetic lipid and glucose patterns on the correlation between FE LDL-C (F-LDL) and ET LDL-C (E-LDL) in patients with coronary artery disease (CAD).	Iron	114-116	component of oligomeric golgi complex 2	Homo sapiens	138-143
29718300-9	2018	Furthermore, MPO associated with erythrocyte fragmentation (r = 0.74, p &lt; 0.001) and iron deposition (p = 0.041), 2 outcomes known to amplify MPO-dependent oxidative stress.	Iron	88-92	myeloperoxidase	Homo sapiens	13-16
29576242-0	2018	Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.	Iron	16-20	iron-sulfur cluster assembly enzyme	Homo sapiens	41-45
29576242-0	2018	Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.	Iron	108-112	iron-sulfur cluster assembly enzyme	Homo sapiens	41-45
29718300-9	2018	Furthermore, MPO associated with erythrocyte fragmentation (r = 0.74, p &lt; 0.001) and iron deposition (p = 0.041), 2 outcomes known to amplify MPO-dependent oxidative stress.	Iron	88-92	myeloperoxidase	Homo sapiens	145-148
29378199-10	2018	Further, we found that iron activated the JNK, ERK and NF-kappaB signaling pathways in vivo.	Iron	23-27	mitogen-activated protein kinase 1	Mus musculus	47-50
29602224-8	2018	Several TOR- and ABA-responsive genes are differentially expressed in tip41, including iron homeostasis, senescence and ethylene-associated genes.	Iron	87-91	target of rapamycin	Arabidopsis thaliana	8-11
29730475-2	2018	Six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a metalloreductase, which is vital for cellular iron uptake and homeostasis.	Iron	111-115	STEAP3 metalloreductase	Homo sapiens	0-50
29730475-2	2018	Six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a metalloreductase, which is vital for cellular iron uptake and homeostasis.	Iron	111-115	STEAP3 metalloreductase	Homo sapiens	52-58
29459227-9	2018	It remains to be studied whether the peroxide-STAT3-hepcidin axis simply acts to continuously compensate for oxygen fluctuations or is directly involved in iron sensing per se.	Iron	156-160	signal transducer and activator of transcription 3	Homo sapiens	46-51
29610275-10	2018	Moreover, LPS increased heme oxygenase-1 (HO1) expression in IMG cells, and iron released because of HO1 activity increased the intracellular labile free-iron pool.	Iron	76-80	heme oxygenase 1	Mus musculus	101-104
29937171-10	2018	In comparing patients with an event (death or recurrence) and no event in the intravenous iron group, a distinct trend was found for decreased transferrin in the event group (median 2.53  g/L vs 2.83  g/L, p = 0.052).	Iron	90-94	transferrin	Homo sapiens	143-154
29802141-3	2018	report a novel cellular system that creates an acute Fe-S cluster deficiency, using mutants of ISCU, the main scaffold protein for Fe-S cluster assembly.	Iron	53-57	iron-sulfur cluster assembly enzyme	Homo sapiens	95-99
29709179-2	2018	Using cytochrome c (cyt c) as a platform, we investigated its structural dynamics during folding processes triggered by local environmental changes (i.e., pH or heme iron center oxidation/spin/ligation states) with time-resolved X-ray solution scattering measurements.	Iron	129-133	cytochrome c, somatic	Homo sapiens	6-18
29709179-2	2018	Using cytochrome c (cyt c) as a platform, we investigated its structural dynamics during folding processes triggered by local environmental changes (i.e., pH or heme iron center oxidation/spin/ligation states) with time-resolved X-ray solution scattering measurements.	Iron	129-133	cytochrome c, somatic	Homo sapiens	20-25
29625173-5	2018	We demonstrate here that human HD and mouse model HD (12-week R6/2 and 12-month YAC128) brains accumulated mitochondrial iron and showed increased expression of iron uptake protein mitoferrin 2 and decreased iron-sulfur cluster synthesis protein frataxin.	Iron	161-165	solute carrier family 25, member 28	Mus musculus	181-193
29544765-1	2018	PURPOSE: The heavy subunit of the iron storage protein ferritin (FHC) is essential for the intracellular iron metabolism and, at the same time, it represents a central hub of iron-independent pathways, such as cell proliferation, angiogenesis, p53 regulation, chemokine signalling, stem cell expansion, miRNAs expression.	Iron	34-38	tumor protein p53	Homo sapiens	244-247
29764842-6	2018	By measuring the transcriptional levels of iron-related proteins (eg, hepcidin, ferroportin, and ferritin), we observed that TLR signaling can induce intracellular iron sequestration in macrophages through 2 independent but redundant mechanisms.	Iron	43-47	toll like receptor 1	Homo sapiens	125-128
29764842-6	2018	By measuring the transcriptional levels of iron-related proteins (eg, hepcidin, ferroportin, and ferritin), we observed that TLR signaling can induce intracellular iron sequestration in macrophages through 2 independent but redundant mechanisms.	Iron	164-168	toll like receptor 1	Homo sapiens	125-128
29764842-9	2018	This is the first study in which TLR1-9-mediated iron homeostasis in human macrophages was evaluated, and the outcome of this study elucidates the mechanism of iron dysregulation in macrophages during infection.	Iron	49-53	toll like receptor 1	Homo sapiens	33-37
29764842-9	2018	This is the first study in which TLR1-9-mediated iron homeostasis in human macrophages was evaluated, and the outcome of this study elucidates the mechanism of iron dysregulation in macrophages during infection.	Iron	160-164	toll like receptor 1	Homo sapiens	33-37
29872401-8	2018	The results of the animal experiments confirmed that a certain degree of iron redundancy may promote bone marrow erythropoiesis and peripheral red blood cell production in hypoxic mice and that decreased IL-10 and IL-22 stimulated iron mobilization during hypoxia by affecting hepcidin expression.	Iron	231-235	interleukin 10	Mus musculus	204-209
29625173-5	2018	We demonstrate here that human HD and mouse model HD (12-week R6/2 and 12-month YAC128) brains accumulated mitochondrial iron and showed increased expression of iron uptake protein mitoferrin 2 and decreased iron-sulfur cluster synthesis protein frataxin.	Iron	161-165	solute carrier family 25, member 28	Mus musculus	181-193
29883401-1	2018	Matriptase-2 is a type II transmembrane serine protease and a key regulator of systemic iron homeostasis.	Iron	88-92	transmembrane serine protease 6	Homo sapiens	0-12
29610275-10	2018	Moreover, LPS increased heme oxygenase-1 (HO1) expression in IMG cells, and iron released because of HO1 activity increased the intracellular labile free-iron pool.	Iron	154-158	heme oxygenase 1	Mus musculus	101-104
29771935-7	2018	Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression.	Iron	9-13	nuclear factor kappa B subunit 1	Homo sapiens	113-122
29771935-7	2018	Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression.	Iron	9-13	nitric oxide synthase 2	Homo sapiens	164-168
29771935-7	2018	Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression.	Iron	9-13	interleukin 1 beta	Homo sapiens	170-178
29771935-7	2018	Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression.	Iron	9-13	interleukin 6	Homo sapiens	180-184
29771935-7	2018	Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression.	Iron	9-13	tumor necrosis factor	Homo sapiens	196-204
29771984-1	2018	Production of the iron regulatory peptide hepcidin is tightly controlled by a network of proteins in hepatocytes that sense levels of iron in the circulation (as diferric-transferrin) and in tissues (in ferritin).	Iron	18-22	transferrin	Homo sapiens	171-182
29771984-1	2018	Production of the iron regulatory peptide hepcidin is tightly controlled by a network of proteins in hepatocytes that sense levels of iron in the circulation (as diferric-transferrin) and in tissues (in ferritin).	Iron	134-138	transferrin	Homo sapiens	171-182
29648809-0	2018	Iron(MCP) Complexes Catalyze Aziridination with Olefins As Limiting Reagents.	Iron	0-4	CD46 molecule	Homo sapiens	5-8
29351867-5	2018	Furthermore, non-target proteins including the iron-free apo-Trf were discriminated by pronounced size and shape specificity.	Iron	47-51	transferrin	Homo sapiens	61-64
28874056-9	2018	INNOVATION: CP alterations in iron contents were mediated through DMT1(-IRE) and changes in ROS levels, which in turn attenuated the progression of AD through the Erk/p38 and Bcl-2/Bax signaling pathways.	Iron	30-34	B cell leukemia/lymphoma 2	Mus musculus	175-180
29580991-3	2018	Recently, ferritin heavy chain (FTH1) has been characterized to reinforce the HIF-1 signaling pathway in an indirect way through the inhibition of PHD activity by depleting the free iron pool in the cytoplasm.	Iron	182-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-83
28874056-9	2018	INNOVATION: CP alterations in iron contents were mediated through DMT1(-IRE) and changes in ROS levels, which in turn attenuated the progression of AD through the Erk/p38 and Bcl-2/Bax signaling pathways.	Iron	30-34	mitogen-activated protein kinase 1	Mus musculus	163-166
29681108-1	2018	WDR45 gene-associated neurodegeneration with brain iron accumulation (NBIA), referred to as beta-propeller protein-associated neurodegeneration (BPAN), is a rare disorder that presents with a very nonspecific clinical phenotype in children constituting global developmental delay.	Iron	51-55	WD repeat domain 45	Homo sapiens	0-5
28515173-9	2018	Iron supplementation with ferric ammonium citrate in erastin-treated cells decreased cell viability further in HO-1-/- PTCs compared with HO-1+/+ cells.	Iron	0-4	heme oxygenase 1	Mus musculus	111-115
28515173-9	2018	Iron supplementation with ferric ammonium citrate in erastin-treated cells decreased cell viability further in HO-1-/- PTCs compared with HO-1+/+ cells.	Iron	0-4	heme oxygenase 1	Mus musculus	138-142
29373036-7	2018	Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1beta and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3-/- livers.	Iron	173-177	interleukin 1 beta	Mus musculus	88-96
29490582-0	2018	Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence.	Iron	51-55	regucalcin	Rattus norvegicus	19-47
29466707-1	2018	BACKGROUND: Transferrin and its receptors play an important role during the uptake and transcytosis of iron through blood-brain barrier (BBB) endothelial cells (ECs) to maintain iron homeostasis in BBB endothelium and brain.	Iron	103-107	transferrin	Homo sapiens	12-23
29466707-1	2018	BACKGROUND: Transferrin and its receptors play an important role during the uptake and transcytosis of iron through blood-brain barrier (BBB) endothelial cells (ECs) to maintain iron homeostasis in BBB endothelium and brain.	Iron	178-182	transferrin	Homo sapiens	12-23
29466707-4	2018	METHODS: Ordinary differential equations are formulated based on the first order reaction kinetics to model the iron transport considering their interactions with transferrin and transferrin receptors.	Iron	112-116	transferrin	Homo sapiens	163-174
29466707-4	2018	METHODS: Ordinary differential equations are formulated based on the first order reaction kinetics to model the iron transport considering their interactions with transferrin and transferrin receptors.	Iron	112-116	transferrin	Homo sapiens	179-190
29466707-7	2018	Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes.	Iron	88-92	transferrin	Homo sapiens	122-133
29466707-7	2018	Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes.	Iron	88-92	transferrin	Homo sapiens	210-221
29466707-7	2018	Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes.	Iron	88-92	transferrin	Homo sapiens	210-221
29466707-7	2018	Model results also suggest that the BBB ECs can regulate the extent of the two possible iron transport pathways (free and transferrin-bound iron) by controlling the receptor expression, internalization of holo-transferrin-receptor complexes and acidification of holo-transferrin inside the cell endosomes.	Iron	140-144	transferrin	Homo sapiens	122-133
29466707-9	2018	The model can also predict the transferrin and iron transport behavior in iron-enriched and iron-depleted cells, which has not been addressed in previous work.	Iron	74-78	transferrin	Homo sapiens	31-42
29466707-9	2018	The model can also predict the transferrin and iron transport behavior in iron-enriched and iron-depleted cells, which has not been addressed in previous work.	Iron	74-78	transferrin	Homo sapiens	31-42
29490582-1	2018	To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray.	Iron	111-115	regucalcin	Rattus norvegicus	71-99
29490582-1	2018	To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray.	Iron	111-115	regucalcin	Rattus norvegicus	101-106
29490582-3	2018	Our data suggested that down-regulation of SMP30 drives cell senescence in iron-chelated condition.	Iron	75-79	regucalcin	Rattus norvegicus	43-48
29436580-6	2018	Iron-deficient cells exhibited morphological abnormalities and demonstrated a significant increase in the expression of Atrogin-1 (P&lt;0.05) and MuRF1 (P&lt;0.05) both in normoxia and hypoxia, which indicated activation of the ubiquitin proteasome pathway associated with protein degradation during muscle atrophy.	Iron	0-4	tripartite motif containing 63	Homo sapiens	146-151
29178028-7	2018	In comparison to LICb, LICR2* and LICSIR detect liver iron overload with a sensitivity/specificity of 0.96/0.93 and 0.92/0.95, respectively, and a bias +- SD of 7.6 +- 73.4 and 14.8 +- 37.6 mumol/g, respectively.	Iron	54-58	interferon lambda receptor 1	Homo sapiens	23-28
29177638-1	2018	Iron efflux in mammalian cells is mediated by the ferrous iron exporter ferroportin (Fpn); Fpn plasma membrane localization and function are supported by a multicopper ferroxidase and/or the soluble amyloid precursor protein (sAPP).	Iron	0-4	amyloid beta precursor protein	Homo sapiens	199-224
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	21-25	poly(rC) binding protein 1	Homo sapiens	49-74
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	21-25	poly(rC) binding protein 1	Homo sapiens	76-81
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	191-195	poly(rC) binding protein 1	Homo sapiens	49-74
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	191-195	poly(rC) binding protein 1	Homo sapiens	76-81
29414334-6	2018	For metals, Fe, Cr, and Rb were dominant in the raw leachate, detected at 7.55, 2.82, and 4.50 mg L-1, respectively.	Iron	12-14	immunoglobulin kappa variable 1-16	Homo sapiens	98-101
29484788-7	2018	Four days of iron depletion resulted in an 84% decrease in ferritin (P &lt; 0.0001) and significantly increased gene expression of transferrin receptor 1 and divalent metal transporter 1 (both P &lt; 0.001).	Iron	13-17	transferrin	Homo sapiens	131-142
29484788-11	2018	Supplementation of transferrin-bound iron recovered functional and morphological abnormalities within 3 days.	Iron	37-41	transferrin	Homo sapiens	19-30
29436580-10	2018	Notably, in hypoxia, an increased expression of Atrogin-1 and MuRF1 was associated with an increased expression of transferrin receptor 1, reflecting intracellular iron demand (R=0.76, P&lt;0.01; R=0.86, P&lt;0.01).	Iron	164-168	tripartite motif containing 63	Homo sapiens	62-67
29449016-6	2018	Pulse radiolysis experiments, however, clearly revealed an axial ligand exchange from Cys to His immediately after the reduction of the heme iron to form a 5-coordinate His-ligated heme in heme-bound IRP2, whereas the 5-coordinate His-ligated heme was not observed after the reduction of heme-bound IRP1.	Iron	141-145	iron responsive element binding protein 2	Homo sapiens	200-204
29248829-0	2018	Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.	Iron	52-56	transferrin	Rattus norvegicus	62-64
28939683-7	2018	CONCLUSIONS: Iron might facilitate Abeta deposition in Alzheimer"s and accelerate the disease process.	Iron	13-17	amyloid beta precursor protein	Homo sapiens	35-40
28941588-1	2018	The cysteine desulfurase Nfs1/Isd11 uses the amino acid cysteine as the substrate and its activity is absolutely required for contributing persulfide sulfur to the essential process of iron-sulfur (Fe-S) cluster assembly in mitochondria.	Iron	198-202	cysteine desulfurase	Saccharomyces cerevisiae S288C	25-29
28941588-9	2018	We propose that Nfs1 phosphorylation may provide a means of rapid adaptation to increased metabolic demand for sulfur and Fe-S clusters within mitochondria.	Iron	122-126	cysteine desulfurase	Saccharomyces cerevisiae S288C	16-20
29576065-3	2018	Citrate is a primary iron chelator, and the transporter FERRIC REDUCTASE DEFECTIVE 3 (FRD3) loads citrate into the xylem.	Iron	21-25	MATE efflux family protein	Arabidopsis thaliana	86-90
29576065-4	2018	We have expressed AtFRD3 in combination with AtNAS1 (NICOTIANAMINE SYNTHASE 1) and PvFER (FERRITIN) or with PvFER alone to facilitate long-distance iron transport together with efficient iron uptake and storage in the rice endosperm.	Iron	148-152	MATE efflux family protein	Arabidopsis thaliana	18-24
29576065-4	2018	We have expressed AtFRD3 in combination with AtNAS1 (NICOTIANAMINE SYNTHASE 1) and PvFER (FERRITIN) or with PvFER alone to facilitate long-distance iron transport together with efficient iron uptake and storage in the rice endosperm.	Iron	187-191	MATE efflux family protein	Arabidopsis thaliana	18-24
29248829-0	2018	Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.	Iron	0-4	transferrin	Rattus norvegicus	12-23
29248829-0	2018	Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.	Iron	0-4	transferrin	Rattus norvegicus	25-27
29510335-1	2018	The Met80-heme iron bond of cytochrome c (cyt c) is cleaved by the interaction of cyt c with cardiolipin (CL) in membranes.	Iron	15-19	cytochrome c, somatic	Homo sapiens	28-40
29510335-1	2018	The Met80-heme iron bond of cytochrome c (cyt c) is cleaved by the interaction of cyt c with cardiolipin (CL) in membranes.	Iron	15-19	cytochrome c, somatic	Homo sapiens	42-47
29510335-1	2018	The Met80-heme iron bond of cytochrome c (cyt c) is cleaved by the interaction of cyt c with cardiolipin (CL) in membranes.	Iron	15-19	cytochrome c, somatic	Homo sapiens	82-87
29768385-9	2018	Special attention should be paid to the metabolism of iron, protein, and bile acid in patients with a low PG I/II ratio.	Iron	54-58	biglycan	Homo sapiens	106-110
29343315-1	2018	OBJECTIVE: To assess the impact of the acute-phase response (APR) during inflammation on Fe, Zn and vitamin A biomarkers to allow accurate evaluation of micronutrient status in populations.	Iron	89-91	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	61-64
29248829-0	2018	Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.	Iron	52-56	transferrin	Rattus norvegicus	62-64
29248829-2	2018	The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective.	Iron	149-153	transferrin	Rattus norvegicus	159-170
29248829-3	2018	We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma.	Iron	90-94	transferrin	Rattus norvegicus	102-113
29481068-4	2018	Here, we describe the switchable display of the iron-transporting protein, transferrin (Tf), at the surface of thermoresponsive polymer-coated gold nanoparticles and show that internalization of the coated nanoparticles into target cells changes across temperature ranges over which transferrin is expected to be sterically "hidden" by an extended polymer chain and then "revealed" by polymer chain collapse.	Iron	48-52	transferrin	Homo sapiens	75-86
29700330-8	2018	Peripheral challenge with glucose and insulin revealed blunting of the response in iron-overloaded PrP+/+ relative to PrP-/- mice, suggesting that PrPC-mediated modulation of IC iron influences both secretion and sensitivity of peripheral organs to insulin.	Iron	83-87	insulin	Homo sapiens	249-256
29398562-4	2018	Here we show that SOD2, which normally binds manganese, can incorporate iron and generate an alternative isoform with peroxidase activity.	Iron	72-76	superoxide dismutase 2, mitochondrial	Mus musculus	18-22
29611701-5	2018	Also, Fe,Co,N-CNP(0.3) presents comparable ORR catalytic activity as Pt/C in the acidic electrolyte with E1/2 of 0.764 V and superior methanol tolerance and electrochemical stability.	Iron	6-8	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	14-17
29611701-6	2018	The outstanding ORR performance of Fe,Co,N-CNP(0.3) is ascribed to the synergistic contribution of homogeneous Fe, Co, and N codoping structure, high SSA, and hierarchically porous structure for rapid mass transport.	Iron	35-37	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	43-46
29611701-6	2018	The outstanding ORR performance of Fe,Co,N-CNP(0.3) is ascribed to the synergistic contribution of homogeneous Fe, Co, and N codoping structure, high SSA, and hierarchically porous structure for rapid mass transport.	Iron	111-113	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	43-46
29881816-0	2018	Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease.	Iron	8-12	insulin	Homo sapiens	43-50
29881816-3	2018	This study forms part of the Impact of Iron on Insulin Resistance and Liver Histology in Nonalcoholic Steatohepatitis (IIRON2) study, a prospective randomized controlled trial of venesection for adults with NAFLD.	Iron	39-43	insulin	Homo sapiens	47-54
29700330-5	2018	Silencing of PrPC in 1.1B4 cells resulted in significant depletion of intracellular (IC) iron, and remarkably, upregulation of glucose transporter GLUT2 and insulin.	Iron	89-93	prion protein	Homo sapiens	13-17
29700330-6	2018	Iron overloading, on the other hand, resulted in downregulation of GLUT2 and insulin in a PrPC-dependent manner.	Iron	0-4	insulin	Homo sapiens	77-84
29700330-6	2018	Iron overloading, on the other hand, resulted in downregulation of GLUT2 and insulin in a PrPC-dependent manner.	Iron	0-4	prion protein	Homo sapiens	90-94
29700330-8	2018	Peripheral challenge with glucose and insulin revealed blunting of the response in iron-overloaded PrP+/+ relative to PrP-/- mice, suggesting that PrPC-mediated modulation of IC iron influences both secretion and sensitivity of peripheral organs to insulin.	Iron	83-87	insulin	Homo sapiens	38-45
29652073-1	2018	In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor.	Iron	79-83	iron responsive element binding protein 2	Homo sapiens	174-178
29652073-1	2018	In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor.	Iron	139-143	iron responsive element binding protein 2	Homo sapiens	174-178
29652073-1	2018	In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor.	Iron	188-192	iron responsive element binding protein 2	Homo sapiens	174-178
29611701-2	2018	Herein, we present a novel and facile route for synthesis of iron-, cobalt-, and nitrogen-codoped carbon nanopolyhedra electrocatalysts (Fe,Co,N-CNP) by one-step pyrolysis of a new type of Fe/Co bimetal zeolitic imidazolate framework (Fe,Co-ZIF) crystals that were self-assembled by oxygen-free solvothermal reaction of Fe2+ and Co2+ with 2-methylimidazole.	Iron	61-65	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	145-148
29611701-2	2018	Herein, we present a novel and facile route for synthesis of iron-, cobalt-, and nitrogen-codoped carbon nanopolyhedra electrocatalysts (Fe,Co,N-CNP) by one-step pyrolysis of a new type of Fe/Co bimetal zeolitic imidazolate framework (Fe,Co-ZIF) crystals that were self-assembled by oxygen-free solvothermal reaction of Fe2+ and Co2+ with 2-methylimidazole.	Iron	137-139	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	145-148
29611701-2	2018	Herein, we present a novel and facile route for synthesis of iron-, cobalt-, and nitrogen-codoped carbon nanopolyhedra electrocatalysts (Fe,Co,N-CNP) by one-step pyrolysis of a new type of Fe/Co bimetal zeolitic imidazolate framework (Fe,Co-ZIF) crystals that were self-assembled by oxygen-free solvothermal reaction of Fe2+ and Co2+ with 2-methylimidazole.	Iron	189-191	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	145-148
29611701-4	2018	The optimized Fe,Co,N-CNP(0.3) (Fe/Co molar ratio of 0.3 in Fe,Co-ZIF) electrocatalyst exhibited a highly promising activity for oxygen reduction reaction (ORR) with a positive half-wave potential ( E1/2) of 0.875 V (29 mV higher than that of the commercial Pt/C), excellent methanol tolerance, and electrochemical stability in the alkaline electrolyte.	Iron	14-16	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	22-25
29611701-4	2018	The optimized Fe,Co,N-CNP(0.3) (Fe/Co molar ratio of 0.3 in Fe,Co-ZIF) electrocatalyst exhibited a highly promising activity for oxygen reduction reaction (ORR) with a positive half-wave potential ( E1/2) of 0.875 V (29 mV higher than that of the commercial Pt/C), excellent methanol tolerance, and electrochemical stability in the alkaline electrolyte.	Iron	32-34	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	22-25
29481068-4	2018	Here, we describe the switchable display of the iron-transporting protein, transferrin (Tf), at the surface of thermoresponsive polymer-coated gold nanoparticles and show that internalization of the coated nanoparticles into target cells changes across temperature ranges over which transferrin is expected to be sterically "hidden" by an extended polymer chain and then "revealed" by polymer chain collapse.	Iron	48-52	transferrin	Homo sapiens	88-90
29481068-4	2018	Here, we describe the switchable display of the iron-transporting protein, transferrin (Tf), at the surface of thermoresponsive polymer-coated gold nanoparticles and show that internalization of the coated nanoparticles into target cells changes across temperature ranges over which transferrin is expected to be sterically "hidden" by an extended polymer chain and then "revealed" by polymer chain collapse.	Iron	48-52	transferrin	Homo sapiens	283-294
30105281-0	2018	Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes.	Iron	0-4	apolipoprotein E	Homo sapiens	31-47
29524511-1	2018	The yeast Saccharomyces cerevisiae monothiol glutaredoxin Grx3 plays a key role in cellular defense against oxidative stress and more importantly, cooperates with BolA-like iron repressor of activation protein Fra2 to regulate the localization of the iron-sensing transcription factor Aft2.	Iron	173-177	Aft2p	Saccharomyces cerevisiae S288C	285-289
29659573-7	2018	Current whole-body models lack the mechanistic details of iron transport related to RBC maturation, transferrin (Tf and TfR) dynamics and assume passive iron efflux from macrophages.	Iron	58-62	transferrin	Homo sapiens	100-111
29524511-2	2018	The interplay among Grx3, Fra2 and Aft2 responsible for the regulation of iron homeostasis has not been clearly described.	Iron	74-78	Aft2p	Saccharomyces cerevisiae S288C	35-39
29779334-0	2018	[Effect of iron chelation therapy on EPO-Stat5 signaling pathway and Treg expression in IPSS low risk/medium risk-1 group myelodysplastic syndrome patients].	Iron	11-15	erythropoietin	Homo sapiens	37-40
29524511-7	2018	These structural and biochemical analyses enabled us to propose a model how Grx3 executes multiple functions to coordinate the regulation of Aft2-controlled iron metabolism.	Iron	157-161	Aft2p	Saccharomyces cerevisiae S288C	141-145
29558149-1	2018	A continuous mesofluidic process has been developed for benzylic C-H oxidation with moderate to good yields using a photocatalyst (riboflavin tetraacetate, RFT) activated by a UV lamp and an iron additive [Fe(ClO4)2] via incorporation of singlet oxygen (1O2) for the direct formation of oxidized C O or CH-OH compounds.	Iron	191-195	methyl-CpG binding domain protein 1	Homo sapiens	156-159
29682453-2	2018	This testing revealed pathogenic mutations in a gene not previously associated with RTT, CTNNB1, mutations in which lead to an autosomal dominant neurodevelopmental disorder affecting cell signaling and transcription factors as well as a likely pathogenic mutation in the WDR45 gene, which is associated with developmental delay in early childhood and progressive neurodegeneration in adolescence or adulthood related to iron accumulation in the globus pallidus and substantia nigra.	Iron	421-425	WD repeat domain 45	Homo sapiens	272-277
29695998-3	2018	However, p53 has a number of other functions that recent data strongly implicate in tumor suppression, particularly with regard to the control of metabolism and ferroptosis (iron- and lipid-peroxide-mediated cell death) by p53.	Iron	174-178	tumor protein p53	Homo sapiens	9-12
29695998-3	2018	However, p53 has a number of other functions that recent data strongly implicate in tumor suppression, particularly with regard to the control of metabolism and ferroptosis (iron- and lipid-peroxide-mediated cell death) by p53.	Iron	174-178	tumor protein p53	Homo sapiens	223-226
29765892-1	2018	Pantothenate kinase-associated neurodegeneration (PKAN) is a neurodegenerative disorder characterized by iron accumulation in the globus pallidus (GP) of the brain (neurodegeneration with brain iron accumulation [NBIA]), which is characterized by dystonia and spasticity resulting in postural difficulties.	Iron	105-109	pantothenate kinase 2	Homo sapiens	0-48
29765892-1	2018	Pantothenate kinase-associated neurodegeneration (PKAN) is a neurodegenerative disorder characterized by iron accumulation in the globus pallidus (GP) of the brain (neurodegeneration with brain iron accumulation [NBIA]), which is characterized by dystonia and spasticity resulting in postural difficulties.	Iron	105-109	pantothenate kinase 2	Homo sapiens	50-54
29765892-1	2018	Pantothenate kinase-associated neurodegeneration (PKAN) is a neurodegenerative disorder characterized by iron accumulation in the globus pallidus (GP) of the brain (neurodegeneration with brain iron accumulation [NBIA]), which is characterized by dystonia and spasticity resulting in postural difficulties.	Iron	194-198	pantothenate kinase 2	Homo sapiens	0-48
29765892-1	2018	Pantothenate kinase-associated neurodegeneration (PKAN) is a neurodegenerative disorder characterized by iron accumulation in the globus pallidus (GP) of the brain (neurodegeneration with brain iron accumulation [NBIA]), which is characterized by dystonia and spasticity resulting in postural difficulties.	Iron	194-198	pantothenate kinase 2	Homo sapiens	50-54
29329501-0	2018	Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey.	Iron	42-46	hepcidin	Macaca fascicularis	78-86
29541456-6	2018	The results demonstrated that VPA attenuated the activation of iron-rich BV2 cells induced by LPS by down-regulating the mRNA expression of inducible nitric oxide (NO) synthase and interleukin 1beta (IL-1beta; P&lt;0.01), to ultimately reduce the production of NO and IL-1beta (P&lt;0.01).	Iron	63-67	interleukin 1 beta	Mus musculus	181-198
29329501-1	2018	BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron-restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis.	Iron	76-80	hepcidin	Macaca fascicularis	145-153
29329501-1	2018	BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron-restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis.	Iron	221-225	hepcidin	Macaca fascicularis	145-153
29329501-4	2018	The development of a novel free hepcidin assay enabled accurate analysis of bioactive hepcidin suppression and elucidation of the observed plasma iron levels after PRS-080-PEG30 administration in vivo.	Iron	146-150	hepcidin	Macaca fascicularis	32-40
29329501-10	2018	CONCLUSIONS AND IMPLICATIONS: In conclusion, we developed a dose-dependent and safe approach for the direct suppression of hepcidin, resulting in prolonged iron mobilization to alleviate iron-restricted erythropoiesis that can address the root cause of ACD.	Iron	156-160	hepcidin	Macaca fascicularis	123-131
28662967-3	2018	Recent data suggest that insulin therapy and probably other diabetes drugs can influence hepcidin production, thus influencing the iron load in cells.	Iron	131-135	insulin	Homo sapiens	25-32
29329501-10	2018	CONCLUSIONS AND IMPLICATIONS: In conclusion, we developed a dose-dependent and safe approach for the direct suppression of hepcidin, resulting in prolonged iron mobilization to alleviate iron-restricted erythropoiesis that can address the root cause of ACD.	Iron	187-191	hepcidin	Macaca fascicularis	123-131
28992067-17	2018	Conclusions: IS affects iron metabolism in CKD by participating in hepcidin regulation via pathways that depend on AhR and oxidative stress.	Iron	24-28	aryl-hydrocarbon receptor	Mus musculus	115-118
29291402-12	2018	Along with increased hepcidin expression, the iron content in brain tissue and the apoptosis rate were increased.	Iron	46-50	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
29291402-13	2018	Thus, CHOP promotes hepcidin expression by regulating C/EBPalpha activity, which increases the brain iron content, induces apoptosis and is involved in the development of EBI after SAH.	Iron	101-105	hepcidin antimicrobial peptide	Rattus norvegicus	20-28
29458730-2	2018	Risk factors for cardiosiderosis are discussed with particular reference to the balance of transfusional iron loading rate and transferrin-iron utilization rate as marked by plasma levels of soluble transferrin receptors.	Iron	139-143	transferrin	Homo sapiens	127-138
29458730-3	2018	Low transfusion regimens increase residual erythropoiesis allowing for apotransferrin-dependent clearance of non-transferrin-bound iron species otherwise destined for myocardium.	Iron	131-135	transferrin	Homo sapiens	74-85
29441715-2	2018	At the cell surface of hepatocytes, TMPRSS6 cleaves haemojuvelin (HJV) and regulates the BMP/SMAD signalling pathway leading to production of hepcidin, a key regulator of iron absorption.	Iron	171-175	transmembrane serine protease 6	Homo sapiens	36-43
29364516-9	2018	Furthermore, iron decreased the expression of nuclear transcription factor EB (TFEB), a master transcriptional regulator of autophagosome-lysosome fusion, and inhibited its nuclear translocation through activating AKT/mTORC1 signaling.	Iron	13-17	thymoma viral proto-oncogene 1	Mus musculus	214-217
28953524-4	2018	A significant relationship was found between reduction of tissue transglutaminase-immunoglobulin A and increase in serum ferritin after institution of a gluten-free diet (P &lt; 0.0001), suggesting that resolution of villous damage is necessary for promoting adequate iron absorption.	Iron	268-272	transglutaminase 2	Homo sapiens	58-81
29486548-2	2018	METHODS: We reviewed 39 women with RLS and iron deficiency, who achieved iron normalization after oral iron replacement for three months.	Iron	73-77	RLS1	Homo sapiens	35-38
29454663-1	2018	INTRODUCTION: Phospholipase A2-associated neurodegeneration (PLAN) is an autosomal recessive movement disorder with abnormal iron deposition in basal ganglia, substantial nigra and adjacent areas, and cerebellar atrophy.	Iron	125-129	phospholipase A2 group IB	Homo sapiens	14-30
29330894-3	2018	For instance, the binuclear nonheme iron site of YtfE, a hemerythrin-like protein involved in the repair of iron centers in Escherichia coli, catalyzes the reduction of nitric oxide to nitrous oxide, and the human F-box/LRR-repeat protein 5, which contains a hemerythrin-like domain, is involved in intracellular iron homeostasis.	Iron	36-40	F-box and leucine rich repeat protein 5	Homo sapiens	214-240
29330894-3	2018	For instance, the binuclear nonheme iron site of YtfE, a hemerythrin-like protein involved in the repair of iron centers in Escherichia coli, catalyzes the reduction of nitric oxide to nitrous oxide, and the human F-box/LRR-repeat protein 5, which contains a hemerythrin-like domain, is involved in intracellular iron homeostasis.	Iron	108-112	F-box and leucine rich repeat protein 5	Homo sapiens	214-240
29330894-3	2018	For instance, the binuclear nonheme iron site of YtfE, a hemerythrin-like protein involved in the repair of iron centers in Escherichia coli, catalyzes the reduction of nitric oxide to nitrous oxide, and the human F-box/LRR-repeat protein 5, which contains a hemerythrin-like domain, is involved in intracellular iron homeostasis.	Iron	108-112	F-box and leucine rich repeat protein 5	Homo sapiens	214-240
29486548-6	2018	The remission rate of RLS with iron replacement was 38.5%.	Iron	31-35	RLS1	Homo sapiens	22-25
29486548-8	2018	CONCLUSION: Almost two-third of RLS patients with iron deficiency showed persistence of the symptom even after iron normalization.	Iron	50-54	RLS1	Homo sapiens	32-35
29332822-3	2018	After photocatalysis, the complex of Fe-humic substances could be transformed into Fe(III) ions, the interference of colored organic matter (e.g., aqueous humic substance) was removed, Fe(III) was enriched selectively onto NMCP with the coexistence of interference metal ions (e.g. Co(II) and Cd(II)) and then transformed into Fe(II) by hydroxylamine and photoreduction and for colorimetric analysis.	Iron	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-288
29295890-6	2018	Conversely, miR-7-5p and miR-141-3p antagomiRs partially but significantly blocked iron- or IRP knockdown-induced down-regulation of TfR1 mRNA, suggesting the interplay between these microRNAs and IRPs along with involvement of another uncharacterized mechanism in TfR1 mRNA degradation.	Iron	83-87	microRNA 141	Homo sapiens	25-32
29596470-10	2018	Interestingly, we show that hypoxia promotes the downregulation of several proteins (ISCU, NFS1, FXN) involved in the early steps of mitochondrial Fe-S cluster biogenesis.	Iron	147-151	iron-sulfur cluster assembly enzyme	Homo sapiens	85-89
29636978-5	2018	Results: When analyses were restricted to mothers without iron supplementation during late pregnancy, negative associations were found between the maternal transferrin saturation score and childhood forced expiratory volume in 1 s and forced vital capacity (difference in age, height and gender-adjusted SD units per SD increase in genotypic score: -0.05 (-0.09, -0.01) p=0.03, and -0.04 (-0.08, 0.00) p=0.04, respectively).	Iron	58-62	transferrin	Homo sapiens	156-167
29528080-2	2018	N-Methylimidazole (MeIm) solvates of vanadium(ii), chromium(ii) and iron(ii) phthalocyanines: [VII(MeIm)2(Pc2-)]0 MeIm (1) and [MII(MeIm)2(Pc2-)]0 2C6H4Cl2 (M = V (2), Cr (3), and Fe (4)) have been obtained and studied in a crystalline form.	Iron	68-72	polycystin 2, transient receptor potential cation channel	Homo sapiens	106-109
30718940-5	2018	Resulting composite membranes were permeable to water at all stages of production, and a UF PSf membrane with 90 nm of nanoporous Fe/Pd on top showed a flux of 183 LHM/bar.	Iron	130-132	insulin like growth factor binding protein 7	Homo sapiens	92-95
29572489-3	2018	Irp1 or Irp2-null mutation is known to reduce the cellular iron level by decreasing transferrin receptor 1 and increasing ferritin.	Iron	59-63	iron responsive element binding protein 2	Homo sapiens	8-12
30966402-0	2018	Sorption of Hg(II) and Pb(II) Ions on Chitosan-Iron(III) from Aqueous Solutions: Single and Binary Systems.	Iron	47-51	submaxillary gland androgen regulated protein 3B	Homo sapiens	23-29
29572489-4	2018	Here, we report that Irp1 or Irp2-null mutation also causes downregulation of frataxin and IscU, two of the core components in the iron-sulfur cluster biogenesis machinery.	Iron	131-135	iron responsive element binding protein 2	Homo sapiens	29-33
29572489-4	2018	Here, we report that Irp1 or Irp2-null mutation also causes downregulation of frataxin and IscU, two of the core components in the iron-sulfur cluster biogenesis machinery.	Iron	131-135	iron-sulfur cluster assembly enzyme	Homo sapiens	91-95
29572489-6	2018	Overexpression of human ISCU and frataxin in Irp1 or Irp2-null cells was able to rescue the defects in iron-sulfur cluster biogenesis and mitochondrial quality.	Iron	103-107	iron-sulfur cluster assembly enzyme	Homo sapiens	24-28
29572489-6	2018	Overexpression of human ISCU and frataxin in Irp1 or Irp2-null cells was able to rescue the defects in iron-sulfur cluster biogenesis and mitochondrial quality.	Iron	103-107	iron responsive element binding protein 2	Homo sapiens	53-57
29518107-0	2018	Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases.	Iron	45-49	apolipoprotein E	Homo sapiens	75-79
29306667-3	2018	Limited As(V) removal was observed at (P/Fe)init that exceeded the critical ratio (P/Fe)crit above which exclusively (Ca-)Fe(III)-phosphate forms.	Iron	41-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	8-13
29306667-4	2018	Effective As(V) removal was observed at (P/Fe)init &lt; (P/Fe)crit, where initial formation of (Ca-)Fe(III)-phosphate is followed by the formation of Si-ferrihydrite in Si-containing electrolytes and of poorly-crystalline lepidocrocite and hydrous ferric oxide in the Si-free electrolytes.	Iron	43-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-15
29210568-1	2018	IscU, the central scaffold protein in the bacterial ISC iron-sulfur (Fe-S) cluster biosynthesis system, has long been recognized to bind a Zn2+ ion at its active site.	Iron	69-73	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
29210568-2	2018	While initially regarded as an artifact, Zn2+ binding has been shown to induce stabilization of the IscU structure that may mimic a state biologically relevant to IscU"s role in Fe-S cluster biosynthesis.	Iron	178-182	iron-sulfur cluster assembly enzyme	Homo sapiens	100-104
29210568-2	2018	While initially regarded as an artifact, Zn2+ binding has been shown to induce stabilization of the IscU structure that may mimic a state biologically relevant to IscU"s role in Fe-S cluster biosynthesis.	Iron	178-182	iron-sulfur cluster assembly enzyme	Homo sapiens	163-167
29210568-3	2018	More recent studies have revealed that SufU, a homologous protein involved in Fe-S cluster biosynthesis in Gram-positive bacteria, also binds a Zn2+ ion with structural implications.	Iron	78-80	SUFU negative regulator of hedgehog signaling	Homo sapiens	39-43
29210568-7	2018	Monitoring and comparing the conformational behavior and stabilization afforded by different transition metal ions upon IscU and SufU revealed similarities between the two proteins and suggest that metal-dependent conformational transitions may be characteristic of U-type proteins involved in Fe-S cluster biosynthesis.	Iron	294-298	iron-sulfur cluster assembly enzyme	Homo sapiens	120-124
29210568-7	2018	Monitoring and comparing the conformational behavior and stabilization afforded by different transition metal ions upon IscU and SufU revealed similarities between the two proteins and suggest that metal-dependent conformational transitions may be characteristic of U-type proteins involved in Fe-S cluster biosynthesis.	Iron	294-298	SUFU negative regulator of hedgehog signaling	Homo sapiens	129-133
29538394-11	2018	Notably, ceruloplasmin precursor (CP), a protein-coding gene participating in antioxidant and iron transport processes, was differentially expressed in all stages.	Iron	94-98	ceruloplasmin	Sus scrofa	9-22
29518107-4	2018	In details, four genes of iron homeostasis (Hemochromatosis (HFE: C282Y, H63D), Ferroportin (FPN1: -8CG), Hepcidin (HAMP: -582AG), Transferrin (TF: P570S)), and the three major alleles of APOE (APOE2, APOE3, APOE4) were analyzed to explore causative interactions and synergies.	Iron	26-30	transferrin	Homo sapiens	131-142
29518107-4	2018	In details, four genes of iron homeostasis (Hemochromatosis (HFE: C282Y, H63D), Ferroportin (FPN1: -8CG), Hepcidin (HAMP: -582AG), Transferrin (TF: P570S)), and the three major alleles of APOE (APOE2, APOE3, APOE4) were analyzed to explore causative interactions and synergies.	Iron	26-30	apolipoprotein E	Homo sapiens	188-192
29518107-4	2018	In details, four genes of iron homeostasis (Hemochromatosis (HFE: C282Y, H63D), Ferroportin (FPN1: -8CG), Hepcidin (HAMP: -582AG), Transferrin (TF: P570S)), and the three major alleles of APOE (APOE2, APOE3, APOE4) were analyzed to explore causative interactions and synergies.	Iron	26-30	apolipoprotein E	Homo sapiens	194-199
29518107-4	2018	In details, four genes of iron homeostasis (Hemochromatosis (HFE: C282Y, H63D), Ferroportin (FPN1: -8CG), Hepcidin (HAMP: -582AG), Transferrin (TF: P570S)), and the three major alleles of APOE (APOE2, APOE3, APOE4) were analyzed to explore causative interactions and synergies.	Iron	26-30	apolipoprotein E	Homo sapiens	201-206
29518107-4	2018	In details, four genes of iron homeostasis (Hemochromatosis (HFE: C282Y, H63D), Ferroportin (FPN1: -8CG), Hepcidin (HAMP: -582AG), Transferrin (TF: P570S)), and the three major alleles of APOE (APOE2, APOE3, APOE4) were analyzed to explore causative interactions and synergies.	Iron	26-30	apolipoprotein E	Homo sapiens	208-213
29518107-9	2018	Conversely, the coexistence in patients of a substantial number of iron SNPs accrued the APOE4 detrimental effect on MMSE.	Iron	67-71	apolipoprotein E	Homo sapiens	89-94
32254421-6	2018	Furthermore, the Fe-incorporated titanium substrates significantly enhanced the expressions of osteogenic genes (such as Runx2, Col I, OPN, and OCN), which were attributed to the synergistic effects of micro-nano structures and Fe ions.	Iron	17-19	RUNX family transcription factor 2	Homo sapiens	121-126
29518107-10	2018	Overall, the analysis highlighted how a specific iron-allele burden, defined as different combinations of iron gene variants, might have different effects on cognitive impairment and might modulate the effects of established genetic risk factors such as APOE4.	Iron	49-53	apolipoprotein E	Homo sapiens	254-259
32254421-6	2018	Furthermore, the Fe-incorporated titanium substrates significantly enhanced the expressions of osteogenic genes (such as Runx2, Col I, OPN, and OCN), which were attributed to the synergistic effects of micro-nano structures and Fe ions.	Iron	17-19	bone gamma-carboxyglutamate protein	Homo sapiens	144-147
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	30-34	transferrin	Homo sapiens	43-54
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	30-34	transferrin	Homo sapiens	0-2
29518107-10	2018	Overall, the analysis highlighted how a specific iron-allele burden, defined as different combinations of iron gene variants, might have different effects on cognitive impairment and might modulate the effects of established genetic risk factors such as APOE4.	Iron	106-110	apolipoprotein E	Homo sapiens	254-259
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	30-34	transferrin	Homo sapiens	56-58
29399922-0	2018	LDL dinitrosyl iron complex: A new transferrin-independent route for iron delivery in hepatocytes.	Iron	15-19	transferrin	Homo sapiens	35-46
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	69-73	transferrin	Homo sapiens	43-54
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	69-73	transferrin	Homo sapiens	0-2
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	69-73	transferrin	Homo sapiens	56-58
29406711-1	2018	Whereas iron-sulfur (Fe-S) cluster assembly on the wild-type scaffold protein ISCU, as catalyzed by the human cysteine desulfurase complex (NIA)2, exhibits a requirement for frataxin (FXN), in yeast, ISCU variant M108I has been shown to bypass the FXN requirement.	Iron	21-25	iron-sulfur cluster assembly enzyme	Homo sapiens	78-82
29406711-1	2018	Whereas iron-sulfur (Fe-S) cluster assembly on the wild-type scaffold protein ISCU, as catalyzed by the human cysteine desulfurase complex (NIA)2, exhibits a requirement for frataxin (FXN), in yeast, ISCU variant M108I has been shown to bypass the FXN requirement.	Iron	21-25	iron-sulfur cluster assembly enzyme	Homo sapiens	200-204
29194702-11	2018	This study suggests a protective role of HFE in IDA CD patients and confirms the role of TMPRSS6 in predicting oral iron response modulating hepcidin action on iron absorption.	Iron	116-120	transmembrane serine protease 6	Homo sapiens	89-96
29194702-11	2018	This study suggests a protective role of HFE in IDA CD patients and confirms the role of TMPRSS6 in predicting oral iron response modulating hepcidin action on iron absorption.	Iron	160-164	transmembrane serine protease 6	Homo sapiens	89-96
29194702-12	2018	Iron supplementation therapeutic management in CD could depend on TMPRSS6 genotype that could predict persistent IDA despite iron supplementation and GFD.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	66-73
29194702-12	2018	Iron supplementation therapeutic management in CD could depend on TMPRSS6 genotype that could predict persistent IDA despite iron supplementation and GFD.	Iron	125-129	transmembrane serine protease 6	Homo sapiens	66-73
28762519-2	2018	Decreased transferrin and transferrin receptor levels were observed in seminal plasma from idiopathic azoospermia (IA) patients, suggesting disturbed iron metabolism in IA testes.	Iron	150-154	transferrin	Homo sapiens	10-21
28762519-2	2018	Decreased transferrin and transferrin receptor levels were observed in seminal plasma from idiopathic azoospermia (IA) patients, suggesting disturbed iron metabolism in IA testes.	Iron	150-154	transferrin	Homo sapiens	26-37
29032246-2	2018	Novel anti-cancer agents that deplete iron pools demonstrate marked anti-tumor activity and are also active in regulating p21 expression.	Iron	38-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	122-125
29032246-5	2018	Hence, this investigation examined how several iron chelators transcriptionally regulate p21.	Iron	47-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-92
29032246-7	2018	RESULTS: The transcriptional regulation of the p21 promoter by iron chelators was demonstrated to be dependent on the chelator and cell-type examined.	Iron	63-67	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-50
29032941-5	2018	PCBP1 delivers iron to ferritin via a direct protein-protein interaction.	Iron	15-19	poly(rC) binding protein 1	Mus musculus	0-5
29406711-4	2018	We have compared the properties of ISCU, ISCU(M108I), and ISCU(D39V), with and without FXN, in both the cysteine desulfurase step of Fe-S cluster assembly and the overall Fe-S cluster assembly reaction catalyzed by (NIA)2.	Iron	133-137	iron-sulfur cluster assembly enzyme	Homo sapiens	35-39
29544561-0	2018	Measurement of interaction behavior of six biologically important noble metal ions with the iron(III) binding protein, apo-transferrin, using mobility-shift affinity electrophoresis.	Iron	92-96	transferrin	Homo sapiens	123-134
29544561-2	2018	At saturation level 70% of transferrin remains free from iron (apo-transferrin), suggesting a broader scope of binding capabilities with non-iron (III) metal ions.	Iron	57-61	transferrin	Homo sapiens	27-38
29544561-2	2018	At saturation level 70% of transferrin remains free from iron (apo-transferrin), suggesting a broader scope of binding capabilities with non-iron (III) metal ions.	Iron	141-145	transferrin	Homo sapiens	27-38
29127238-13	2018	Understanding the effects of mTOR in preventing iron-mediated cell death will provide a new therapy for patients with myocardial infarction.	Iron	48-52	mechanistic target of rapamycin kinase	Homo sapiens	29-33
29032941-0	2018	Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.	Iron	9-13	poly(rC) binding protein 1	Mus musculus	26-31
29032941-0	2018	Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.	Iron	63-67	poly(rC) binding protein 1	Mus musculus	26-31
29032941-2	2018	We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release.	Iron	126-130	poly(rC) binding protein 1	Mus musculus	60-65
29032941-2	2018	We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release.	Iron	126-130	poly(rC) binding protein 1	Mus musculus	184-189
29399922-0	2018	LDL dinitrosyl iron complex: A new transferrin-independent route for iron delivery in hepatocytes.	Iron	69-73	transferrin	Homo sapiens	35-46
29438506-1	2018	Iron deprivation induces transcription of genes required for iron uptake, and transcription factor Aft1 and Aft2 mediate this by regulating transcriptional program in Saccharomyces cerevisiae.	Iron	0-4	Aft2p	Saccharomyces cerevisiae S288C	108-112
29274359-8	2018	The ferroptotic process induced by hHO-1 overexpression further indicated that HO-1 is a key mediator of BAY-induced ferroptosis that operates through cellular redox regulation and iron accumulation.	Iron	181-185	heme oxygenase 1	Mus musculus	36-40
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	89-93	nuclear receptor coactivator 5	Homo sapiens	203-206
28666715-4	2018	Recently, in 2014, a new factor was discovered, which regulates iron metabolism, independently of iron stores and responds to the increased requirements for iron after stimulation of erythropoiesis by erythropoietin.	Iron	64-68	erythropoietin	Homo sapiens	201-215
29341909-1	2018	Deferoxamine (DFO) to treat iron overload (IO) has been limited by toxicity issues and short circulation times and it would be desirable to prolong circulation to improve non-transferrin bound iron (NTBI) chelation.	Iron	193-197	transferrin	Rattus norvegicus	175-186
29407589-1	2018	OBJECTIVES: Transferrin saturation (TSAT) 20% or less is considered to represent functional iron deficiency in the context of malignant disease, phenomenon mediated through inflammatory changes of iron homeostasis.	Iron	92-96	transferrin	Homo sapiens	12-23
28425083-1	2018	PURPOSE: Both beta thalassemia and restless legs syndrome (RLS) patients share some common pathophysiological characteristics related to iron handling.	Iron	137-141	RLS1	Homo sapiens	59-62
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	60-64	nuclear receptor coactivator 5	Homo sapiens	83-86
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	nuclear receptor coactivator 5	Homo sapiens	83-86
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	nuclear receptor coactivator 5	Homo sapiens	83-86
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	nuclear receptor coactivator 5	Homo sapiens	83-86
29413111-8	2018	Furthermore, cytokine concentrations were independently associated with several mineral concentrations: IL-1beta with higher phosphorus and iron, IL-6 with higher calcium, magnesium, copper and manganese, IL-8 with higher calcium and zinc, and TNF-alpha with lower iron and manganese.	Iron	265-269	tumor necrosis factor	Homo sapiens	244-253
29424844-10	2018	This body of work suggests that increasing mouse brain iron with TMHF potentiates a more human-like Alzheimer"s disease phenotype with iron integration into Abeta plaques and associated microgliosis.	Iron	55-59	amyloid beta precursor protein	Homo sapiens	157-162
29424844-10	2018	This body of work suggests that increasing mouse brain iron with TMHF potentiates a more human-like Alzheimer"s disease phenotype with iron integration into Abeta plaques and associated microgliosis.	Iron	135-139	amyloid beta precursor protein	Homo sapiens	157-162
29266790-3	2018	This study aims to explore whether quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating angiotensin II-L-type voltage-dependent Ca2+ channel (Ang II-LTCC).	Iron	72-76	angiotensinogen	Rattus norvegicus	120-134
29266790-3	2018	This study aims to explore whether quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating angiotensin II-L-type voltage-dependent Ca2+ channel (Ang II-LTCC).	Iron	72-76	angiotensinogen	Rattus norvegicus	174-185
28666715-4	2018	Recently, in 2014, a new factor was discovered, which regulates iron metabolism, independently of iron stores and responds to the increased requirements for iron after stimulation of erythropoiesis by erythropoietin.	Iron	98-102	erythropoietin	Homo sapiens	201-215
28666715-4	2018	Recently, in 2014, a new factor was discovered, which regulates iron metabolism, independently of iron stores and responds to the increased requirements for iron after stimulation of erythropoiesis by erythropoietin.	Iron	98-102	erythropoietin	Homo sapiens	201-215
29512626-3	2018	METHODS: In this study, the prevalence of iron (serum ferritin &lt;100 microg/L or ferritin 100-299 microg/L with transferrin saturation &lt;20%), vitamin B12 (&lt;200 pg/mL), and folate deficiency (&lt;4.0 ng/mL) was evaluated in 101 patients with non-valvular AF with preserved left ventricular ejection fraction and no signs of HF, and the results were compared with 35 age- and gender-matched controls.	Iron	42-46	transferrin	Homo sapiens	114-125
29250797-8	2018	High increase in Hb level after iron infusion was associated with initial higher transferrin and lower ferritin levels (high vs. poor responders: median transferrin 2.9 g/L vs. 2.7 g/L, median ferritin 12 microg/L vs. 27 microg/L).	Iron	32-36	transferrin	Homo sapiens	81-92
29250797-8	2018	High increase in Hb level after iron infusion was associated with initial higher transferrin and lower ferritin levels (high vs. poor responders: median transferrin 2.9 g/L vs. 2.7 g/L, median ferritin 12 microg/L vs. 27 microg/L).	Iron	32-36	transferrin	Homo sapiens	153-164
29411604-0	2018	Fe Stabilization by Intermetallic L10-FePt and Pt Catalysis Enhancement in L10-FePt/Pt Nanoparticles for Efficient Oxygen Reduction Reaction in Fuel Cells.	Iron	0-2	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	34-37
29411604-0	2018	Fe Stabilization by Intermetallic L10-FePt and Pt Catalysis Enhancement in L10-FePt/Pt Nanoparticles for Efficient Oxygen Reduction Reaction in Fuel Cells.	Iron	0-2	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	75-78
29411604-2	2018	Using 8 nm FePt NPs as an example, we demonstrate that Fe can be stabilized more efficiently in a core/shell structured L10-FePt/Pt with a 5 A Pt shell.	Iron	11-13	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	120-123
29541261-4	2018	Method: However, treatment of ApoE-/- homogenates with hydrogen peroxide and iron increased oxidative species by &gt;100%, indicating an equivalent amount of potential oxidative species in latent form.	Iron	77-81	apolipoprotein E	Mus musculus	30-34
29250797-10	2018	IV iron therapy is most effective in patients presenting with more severe anemia, and with higher transferrin and lower ferritin levels, markers for an absolute iron deficiency (ID), compared to functional ID.	Iron	3-7	transferrin	Homo sapiens	98-109
29410996-8	2018	Iron ions participate in regulating Grx2 activity via iron-sulfur cluster formation.	Iron	0-4	glutaredoxin 2	Homo sapiens	36-40
29410996-8	2018	Iron ions participate in regulating Grx2 activity via iron-sulfur cluster formation.	Iron	54-58	glutaredoxin 2	Homo sapiens	36-40
29028493-0	2018	Zeolite-supported nanoscale zero-valent iron: New findings on simultaneous adsorption of Cd(II), Pb(II), and As(III) in aqueous solution and soil.	Iron	40-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	97-103
29503658-6	2018	Further detailed analysis of NtZIP1-like provided evidence that it is localized at the plasma membrane and is involved in Zn but not Fe and Cd transport.	Iron	133-135	zinc transporter 5-like	Nicotiana tabacum	29-35
29497418-7	2018	While Gal-3 enhances erythrophagocytosis, MIF promotes both myeloid cell recruitment and iron retention within the MPS, thereby depriving iron for erythropoiesis.	Iron	89-93	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	42-45
29497418-7	2018	While Gal-3 enhances erythrophagocytosis, MIF promotes both myeloid cell recruitment and iron retention within the MPS, thereby depriving iron for erythropoiesis.	Iron	138-142	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	42-45
20301523-6	1993	MANAGEMENT: Treatment of manifestations: Removal of excess iron by routine phlebotomy to maintain serum ferritin concentration at 50 ng/mL or lower and transferrin-iron saturation below 50%; lifelong hormone replacement therapy for hypogonadism; gonadotropins for fertility/pregnancy; nonsteroidal anti-inflammatory drugs (NSAIDs) and joint replacement for arthropathy; diuretics; routine treatment for cardiac failure and diabetes mellitus.	Iron	164-168	transferrin	Homo sapiens	152-163
29028493-2	2018	In this study, zeolite-supported nanoscale zero-valent iron (Z-NZVI) was synthesized from a simplified liquid-phase reduction of iron(III) salts which simultaneously adsorbed As(III), Cd(II) and Pb(II) from aqueous solution and soil.	Iron	55-59	submaxillary gland androgen regulated protein 3B	Homo sapiens	184-201
29298388-6	2018	In a hybrid Li-air battery test, the Fe@Aza-PON demonstrated performance superior to Pt/C.	Iron	37-39	paraoxonase 1	Homo sapiens	44-47
29439469-1	2018	A rapid, sensitive and specific ultrafiltration inductively-coupled plasma mass spectrometry (UF-ICP-MSICP-MS) method was developed and validated for the quantification of non-transferrin bound iron (NTBI), transferrin bound iron (TBI), drug bound iron (DI) and total iron (TI) in the same rat serum sample after intravenous (IV) administration of iron gluconate nanoparticles in sucrose solution (Ferrlecit ).	Iron	194-198	transferrin	Rattus norvegicus	176-187
29619158-1	2017	Pantothenate kinase-associated neurodegeneration (PKAN) is the most common form of neurodegeneration with brain iron accumulation, it is an autosomal recessive disease due to mutation in PANK 2 on chromosome 20, which causes the accumulation of iron in basal ganglia and production of free radicals that cause degeneration of the cells.	Iron	112-116	pantothenate kinase 2	Homo sapiens	0-48
29619158-1	2017	Pantothenate kinase-associated neurodegeneration (PKAN) is the most common form of neurodegeneration with brain iron accumulation, it is an autosomal recessive disease due to mutation in PANK 2 on chromosome 20, which causes the accumulation of iron in basal ganglia and production of free radicals that cause degeneration of the cells.	Iron	112-116	pantothenate kinase 2	Homo sapiens	50-54
29619158-1	2017	Pantothenate kinase-associated neurodegeneration (PKAN) is the most common form of neurodegeneration with brain iron accumulation, it is an autosomal recessive disease due to mutation in PANK 2 on chromosome 20, which causes the accumulation of iron in basal ganglia and production of free radicals that cause degeneration of the cells.	Iron	112-116	pantothenate kinase 2	Homo sapiens	187-193
29619158-1	2017	Pantothenate kinase-associated neurodegeneration (PKAN) is the most common form of neurodegeneration with brain iron accumulation, it is an autosomal recessive disease due to mutation in PANK 2 on chromosome 20, which causes the accumulation of iron in basal ganglia and production of free radicals that cause degeneration of the cells.	Iron	245-249	pantothenate kinase 2	Homo sapiens	0-48
29619158-1	2017	Pantothenate kinase-associated neurodegeneration (PKAN) is the most common form of neurodegeneration with brain iron accumulation, it is an autosomal recessive disease due to mutation in PANK 2 on chromosome 20, which causes the accumulation of iron in basal ganglia and production of free radicals that cause degeneration of the cells.	Iron	245-249	pantothenate kinase 2	Homo sapiens	50-54
29619158-1	2017	Pantothenate kinase-associated neurodegeneration (PKAN) is the most common form of neurodegeneration with brain iron accumulation, it is an autosomal recessive disease due to mutation in PANK 2 on chromosome 20, which causes the accumulation of iron in basal ganglia and production of free radicals that cause degeneration of the cells.	Iron	245-249	pantothenate kinase 2	Homo sapiens	187-193
29298388-3	2018	Here, we introduce a synthesis strategy for a stable Fe-based electrocatalyst, which was realized by defect-free encapsulation of Fe nanoparticles using a two-dimensional (2D) phenazine-based fused aromatic porous organic network (Aza-PON).	Iron	53-55	paraoxonase 1	Homo sapiens	235-238
29298388-4	2018	The resulting Fe@Aza-PON catalyst showed electrocatalytic activity (half-wave potential, 0.839 V; Tafel slope, 60 mV decade-1) comparable to commercial Pt on activated carbon (Pt/C, 0.826 V and 90 mV decade-1).	Iron	14-16	paraoxonase 1	Homo sapiens	21-24
29298388-5	2018	More importantly, the Fe@Aza-PON displayed outstanding stability (zero current loss even after 100 000 cycles) and tolerance against contamination (methanol and CO poisoning).	Iron	22-24	paraoxonase 1	Homo sapiens	29-32
29228768-1	2018	Mrs3 and Mrs4 are mitochondrial inner membrane proteins that deliver an unidentified cytosolic iron species into the matrix for use in iron-sulfur cluster (ISC) and heme biosynthesis.	Iron	95-99	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-4
29416105-3	2018	Under optimized conditions, the Fe response was linear within the range of 0.01 to 1 muM with a detection limit of 1.2 nM.	Iron	32-34	latexin	Homo sapiens	85-88
29228768-1	2018	Mrs3 and Mrs4 are mitochondrial inner membrane proteins that deliver an unidentified cytosolic iron species into the matrix for use in iron-sulfur cluster (ISC) and heme biosynthesis.	Iron	135-139	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-4
29228768-2	2018	The Mrs3/4 double-deletion strain (DeltaDelta) grew slowly in iron-deficient glycerol/ethanol medium but recovered to wild-type (WT) rates in iron-sufficient medium.	Iron	62-66	Fe(2+) transporter	Saccharomyces cerevisiae S288C	4-8
29228768-2	2018	The Mrs3/4 double-deletion strain (DeltaDelta) grew slowly in iron-deficient glycerol/ethanol medium but recovered to wild-type (WT) rates in iron-sufficient medium.	Iron	142-146	Fe(2+) transporter	Saccharomyces cerevisiae S288C	4-8
29178431-3	2018	Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of CoII from NiII , here studied at 24 and 50  C.	Iron	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-248
29467672-13	2018	By the Cox regression model analysis, serum iron levels &lt;15.1 mumol/l together with higher AFP levels, worse BCLC stages, and larger tumor size showed higher mortality of HBV-related HCC patients (hazard ratio = 2.280, 95% confidence interval, 1.815-2.865; P &lt; 0.001).	Iron	44-48	alpha fetoprotein	Homo sapiens	94-97
29467672-15	2018	The prognosis of HBV- related HCC patients with serum iron levels &lt;15.1 mumol/l together with higher AFP levels, worse BCLC stages, and larger tumor lesion were poor.	Iron	54-58	alpha fetoprotein	Homo sapiens	104-107
29395073-0	2018	Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation.	Iron	91-95	transferrin	Homo sapiens	9-20
29282252-1	2018	Iron-restricted human anemias are associated with the acquisition of marrow resistance to the hematopoietic cytokine erythropoietin (Epo).	Iron	0-4	erythropoietin	Homo sapiens	117-131
29282252-1	2018	Iron-restricted human anemias are associated with the acquisition of marrow resistance to the hematopoietic cytokine erythropoietin (Epo).	Iron	0-4	erythropoietin	Homo sapiens	133-136
29282252-2	2018	Regulation of Epo responsiveness by iron availability serves as the basis for intravenous iron therapy in anemias of chronic disease.	Iron	36-40	erythropoietin	Homo sapiens	14-17
29282252-2	2018	Regulation of Epo responsiveness by iron availability serves as the basis for intravenous iron therapy in anemias of chronic disease.	Iron	90-94	erythropoietin	Homo sapiens	14-17
29282252-4	2018	However, Epo resistance caused by iron restriction selectively impairs proliferation and differentiation while preserving viability.	Iron	34-38	erythropoietin	Homo sapiens	9-12
29406047-8	2018	In contrast, iron chelation decreased ferritin levels by 30% (P &lt; 0.03), inhibited collagen secretion by 60% (P &lt; 0.01), repressed fibrogenic genes alpha-SMA (0.2-fold; P &lt; 0.05) and TGF-beta (0.4-fold; P &lt; 0.01) and reduced levels of TGF-beta RII and phospho-Smad2 proteins.	Iron	13-17	actin alpha 2, smooth muscle, aorta	Mus musculus	154-163
29024598-8	2018	Interactions between IRON and BCAA were observed for proteins indicative of mitochondrial biogenesis (peroxisome proliferator-activated receptor gamma coactivator 1 alpha) and oxidative capacity (cytochrome c oxidase subunit 2 and citrate synthase) (P &lt; 0.05) wherein the combined diet (BL) negated potential benefits of individual diets.	Iron	21-25	PPARG coactivator 1 alpha	Rattus norvegicus	102-170
29208364-5	2018	The expansion of intracellular iron upon dopamine treatment resulted in oxidative stress responses as evidenced by increased expression of nuclear factor erythroid 2-related factor (Nrf2) and hypoxia inducible factor-1alpha.	Iron	31-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-180
29208364-5	2018	The expansion of intracellular iron upon dopamine treatment resulted in oxidative stress responses as evidenced by increased expression of nuclear factor erythroid 2-related factor (Nrf2) and hypoxia inducible factor-1alpha.	Iron	31-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	182-186
29208364-6	2018	As a consequence, the transcriptional expression of stress response genes such as heme oxygenase-1 and the iron export protein ferroportin1 were significantly increased.	Iron	107-111	heme oxygenase 1	Mus musculus	82-98
29208364-6	2018	As a consequence, the transcriptional expression of stress response genes such as heme oxygenase-1 and the iron export protein ferroportin1 were significantly increased.	Iron	107-111	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	127-139
29175080-0	2018	Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in vitro and in vivo.	Iron	9-13	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-69
29285662-1	2018	Lactoferrin (Lf) and transferrin (Tf) are iron-binding proteins that can bind various metal ions.	Iron	42-46	serotransferrin	Bos taurus	21-32
29285662-1	2018	Lactoferrin (Lf) and transferrin (Tf) are iron-binding proteins that can bind various metal ions.	Iron	42-46	serotransferrin	Bos taurus	34-36
28358264-7	2018	At 3 d, CD163-/- mice have less Hb, iron, and blood-brain barrier dysfunction, increased astrogliosis and neovascularization, and no change in heme oxygenase 1 (HO1) expression.	Iron	36-40	CD163 antigen	Mus musculus	8-13
29061364-6	2018	Significantly, retention of iron in microglia increased TNFalpha expression and also increased glycolysis suggesting that increased intracellular iron concentration may drive the metabolic and/or inflammatory changes.	Iron	28-32	tumor necrosis factor	Mus musculus	56-64
29167213-8	2018	RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (beta = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]).	Iron	21-25	transferrin	Homo sapiens	178-189
28358264-8	2018	At 10 d, CD163-/- mice have increased iron and VEGF immunoreactivity, but no significant change in HO1 or astrogliosis.	Iron	38-42	CD163 antigen	Mus musculus	9-14
29359982-19	2018	Low PTH is correlated with increased cardiac iron.	Iron	45-49	parathyroid hormone	Homo sapiens	4-7
29196155-10	2018	Treatment with iron and folic acid although has remarkable efficacy for Hb and body iron stores although for the cost of increasing the associated compartment of total bilirubin, AST and ALT concomitant with decreased GGT levels.	Iron	15-19	solute carrier family 17 member 5	Homo sapiens	179-182
29448571-5	2018	The decrease in FE and PCD of formate production on the Sn/CFP electrode could be mainly originated from the reduction of the SnOx to Sn on the cathode surface during electrolysis.	Iron	16-18	complement factor properdin	Homo sapiens	59-62
29175901-6	2018	Before LAGB, IL-6 correlated negatively with iron, hemoglobin concentration and MCHC; hepcidin correlated inversely with transferrin.	Iron	45-49	interleukin 6	Homo sapiens	13-17
29175901-7	2018	Our data show that 13 months after LAGB, the weight loss is associated with an improvement in inflammation, namely a reduction in IL-6 that may reduce hepcidin production, improving iron availability for erythropoiesis, as shown by more adequate erythrocyte hemoglobinization.	Iron	182-186	interleukin 6	Homo sapiens	130-134
29581821-0	2018	Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology.	Iron	25-29	amyloid beta precursor protein	Homo sapiens	71-83
29379040-6	2018	In Superoxide Dismutase-1 (SOD1) mice, iron accumulation appeared in the cervical spinal cord at symptom onset but disappeared with disease progression (after the onset of atrophy).	Iron	39-43	superoxide dismutase 1, soluble	Mus musculus	3-25
29382736-11	2018	AlgR specifically bound to the prrf2 and pvdS promoters in vitro AlgR-dependent pyoverdine production was additionally influenced by carbon source rather than the extracellular iron concentration per se AlgR phosphorylation effects were also examined in a Drosophila melanogaster feeding, murine acute pneumonia, and punch wound infection models.	Iron	177-181	alginate biosynthesis regulatory protein AlgR	Pseudomonas aeruginosa PAO1	0-4
29382736-13	2018	These results show that the AlgR phosphorylation state can directly, as well as indirectly, modulate the expression of iron acquisition genes that may ultimately impact the ability of P. aeruginosa to establish and maintain an infection.IMPORTANCE Pyoverdine and pyocyanin production are well-known P. aeruginosa virulence factors that obtain extracellular iron from the environment and from host proteins in different manners.	Iron	119-123	alginate biosynthesis regulatory protein AlgR	Pseudomonas aeruginosa PAO1	28-32
29382736-13	2018	These results show that the AlgR phosphorylation state can directly, as well as indirectly, modulate the expression of iron acquisition genes that may ultimately impact the ability of P. aeruginosa to establish and maintain an infection.IMPORTANCE Pyoverdine and pyocyanin production are well-known P. aeruginosa virulence factors that obtain extracellular iron from the environment and from host proteins in different manners.	Iron	357-361	alginate biosynthesis regulatory protein AlgR	Pseudomonas aeruginosa PAO1	28-32
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	interleukin 6	Rattus norvegicus	237-241
29382736-10	2018	On the other hand, the PAO1 algR D54E mutant produced higher levels of pyoverdine, likely due to increased expression of an iron-regulated gene encoding the sigma factor pvdS, but it had decreased pyocyanin production.	Iron	124-128	alginate biosynthesis regulatory protein AlgR	Pseudomonas aeruginosa PAO1	28-32
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	interleukin 6	Rattus norvegicus	134-138
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	tumor necrosis factor	Rattus norvegicus	157-166
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	tumor necrosis factor	Rattus norvegicus	203-212
29379040-6	2018	In Superoxide Dismutase-1 (SOD1) mice, iron accumulation appeared in the cervical spinal cord at symptom onset but disappeared with disease progression (after the onset of atrophy).	Iron	39-43	superoxide dismutase 1, soluble	Mus musculus	27-31
29220885-13	2018	The research showed that the combined therapy of patients with CHF and anemia using MEB medication and iron with regard to the EPO level in the blood plasma improved their overall physical condition, reduced heart failure symptoms and hospitalization frequency, and demonstrated a clear tendency to reduce the general mortality rate.	Iron	103-107	erythropoietin	Homo sapiens	127-130
29101239-9	2018	Dietary iron repletion completely reversed ID anemia and ineffective erythropoiesis of Hri-/- , eAA, and Atf4-/- mice by inhibiting both HRI and mTORC1 signaling.	Iron	8-12	activating transcription factor 4	Mus musculus	105-109
29349513-5	2018	For the quantitative description of the effects of the hydrophobic contact and nitrogen-heme-iron coordination on aromatase inhibition, the hydrophobicity density field model and the smallest dual descriptor Deltaf(r) S were introduced, respectively.	Iron	93-97	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	114-123
32254488-0	2018	Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery.	Iron	0-4	transferrin	Homo sapiens	28-39
32254488-0	2018	Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery.	Iron	0-4	insulin	Homo sapiens	80-87
29122540-10	2018	At the same time, with iron intervention, the concentrations of serum SOD decreased but MDA increased; the mRNA expression of osteocalcin and osteoprotegerin (OPG) decreased, whereas that of receptor activator of nuclear factor kappa B ligand (RANKL) and IL-6 increased significantly.	Iron	23-27	bone gamma-carboxyglutamate protein	Rattus norvegicus	126-137
29320706-0	2018	Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.	Iron	46-50	cytosolic iron-sulfur assembly component 2A	Homo sapiens	6-18
29320706-0	2018	Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.	Iron	120-124	cytosolic iron-sulfur assembly component 2A	Homo sapiens	6-18
29122540-10	2018	At the same time, with iron intervention, the concentrations of serum SOD decreased but MDA increased; the mRNA expression of osteocalcin and osteoprotegerin (OPG) decreased, whereas that of receptor activator of nuclear factor kappa B ligand (RANKL) and IL-6 increased significantly.	Iron	23-27	interleukin 6	Rattus norvegicus	255-259
29032057-0	2018	The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation.	Iron	65-69	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	4-9
29433393-3	2018	Pretreatment with EKE (30 and 100[Formula: see text][Formula: see text]g/mL) significantly inhibited AA[Formula: see text][Formula: see text][Formula: see text]iron-mediated cytotoxicity in HepG2 cells by preventing changes in the expression of cleaved caspase-3 and poly(ADP-ribose) polymerase.	Iron	160-164	poly(ADP-ribose) polymerase 1	Homo sapiens	267-294
29433393-6	2018	Furthermore, the cytoprotective effect of EKE against AA[Formula: see text][Formula: see text][Formula: see text]iron was blocked in Nrf2 knockout cells.	Iron	113-117	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
29032057-10	2018	To our knowledge, Hog1p is the first kinase reported to directly regulate Aft1p, impacting on iron homeostasis.	Iron	94-98	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	18-23
29225034-1	2018	The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway functions to incorporate inorganic Fe-S cofactors into a variety of proteins, including several DNA repair enzymes.	Iron	27-31	nuclear receptor coactivator 5	Homo sapiens	51-54
29225034-1	2018	The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway functions to incorporate inorganic Fe-S cofactors into a variety of proteins, including several DNA repair enzymes.	Iron	99-103	nuclear receptor coactivator 5	Homo sapiens	51-54
29563675-0	2018	Identification of iron status of blood donors by using low hemoglobin density and microcytic anemia factor.	Iron	18-22	MAF bZIP transcription factor	Homo sapiens	82-106
29563675-4	2018	Results: : Significant differences were detected in LHD% and Maf values when iron deficient and iron-depleted donors were compared with control donors, while these were insignificant for iron reduced donors.	Iron	77-81	MAF bZIP transcription factor	Homo sapiens	61-64
29563675-4	2018	Results: : Significant differences were detected in LHD% and Maf values when iron deficient and iron-depleted donors were compared with control donors, while these were insignificant for iron reduced donors.	Iron	96-100	MAF bZIP transcription factor	Homo sapiens	61-64
29563675-4	2018	Results: : Significant differences were detected in LHD% and Maf values when iron deficient and iron-depleted donors were compared with control donors, while these were insignificant for iron reduced donors.	Iron	96-100	MAF bZIP transcription factor	Homo sapiens	61-64
29563675-5	2018	LHD and Maf were able to differentiate between iron deficient and iron-depleted donors from normal donors.	Iron	47-51	MAF bZIP transcription factor	Homo sapiens	8-11
29563675-5	2018	LHD and Maf were able to differentiate between iron deficient and iron-depleted donors from normal donors.	Iron	66-70	MAF bZIP transcription factor	Homo sapiens	8-11
29563675-7	2018	Similarly, a cutoff of 10.16 and10.71 for Maf was able to differentiate between iron-deficient and iron-depleted donors from normal donors, respectively.	Iron	80-84	MAF bZIP transcription factor	Homo sapiens	42-45
29563675-7	2018	Similarly, a cutoff of 10.16 and10.71 for Maf was able to differentiate between iron-deficient and iron-depleted donors from normal donors, respectively.	Iron	99-103	MAF bZIP transcription factor	Homo sapiens	42-45
29032057-8	2018	However, Hog1p-Aft1p interaction decreases in isc1Delta cells, which likely contributes to Aft1p dephosphorylation and consequently to Aft1p activation and iron overload in isc1Delta cells.	Iron	156-160	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	9-14
30205391-0	2018	Long Non-Coding RNA PVT1/miR-150/ HIG2 Axis Regulates the Proliferation, Invasion and the Balance of Iron Metabolism of Hepatocellular Carcinoma.	Iron	101-105	hypoxia inducible lipid droplet associated	Homo sapiens	34-38
29318974-7	2018	We hypothesize that the neuroprotective effects of iron chelators are acting against the generation of free radicals derived from iron, and also induce sufficient -but not excessive- activation of HIF-1alpha, so that only the hypoxia-rescue genes will be activated.	Iron	51-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	197-207
29763925-4	2018	Here, we aimed to investigate the effect of iron overload under hyperlipidemia condition on the endothelial injury, inflammation and oxidative stress by employing FPN1 Tek-cre mouse model with or without TMP intervention.	Iron	44-48	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	163-167
29763925-4	2018	Here, we aimed to investigate the effect of iron overload under hyperlipidemia condition on the endothelial injury, inflammation and oxidative stress by employing FPN1 Tek-cre mouse model with or without TMP intervention.	Iron	44-48	TEK receptor tyrosine kinase	Mus musculus	168-171
29073567-1	2018	Fenton-like treatment (FLT) is an ISCO technique relying on the iron-induced H2O2 activation in the presence of additives aimed at increasing the oxidant lifetime and maximizing iron solubility under natural soil pH conditions.	Iron	64-68	fms related receptor tyrosine kinase 1	Homo sapiens	0-21
29073567-1	2018	Fenton-like treatment (FLT) is an ISCO technique relying on the iron-induced H2O2 activation in the presence of additives aimed at increasing the oxidant lifetime and maximizing iron solubility under natural soil pH conditions.	Iron	64-68	fms related receptor tyrosine kinase 1	Homo sapiens	23-26
29073567-1	2018	Fenton-like treatment (FLT) is an ISCO technique relying on the iron-induced H2O2 activation in the presence of additives aimed at increasing the oxidant lifetime and maximizing iron solubility under natural soil pH conditions.	Iron	178-182	fms related receptor tyrosine kinase 1	Homo sapiens	0-21
29073567-1	2018	Fenton-like treatment (FLT) is an ISCO technique relying on the iron-induced H2O2 activation in the presence of additives aimed at increasing the oxidant lifetime and maximizing iron solubility under natural soil pH conditions.	Iron	178-182	fms related receptor tyrosine kinase 1	Homo sapiens	23-26
28814227-1	2018	BACKGROUND: Mitochondrial aconitase (Aco2), a member of the family of iron-sulfur [4Fe- 4S]-containing dehydratases, is involved in cellular metabolism through the tricarboxylic acid cycle.	Iron	70-74	aconitase 2	Homo sapiens	12-35
28814227-1	2018	BACKGROUND: Mitochondrial aconitase (Aco2), a member of the family of iron-sulfur [4Fe- 4S]-containing dehydratases, is involved in cellular metabolism through the tricarboxylic acid cycle.	Iron	70-74	aconitase 2	Homo sapiens	37-41
28814227-2	2018	Aco2 is highly susceptible to oxidative damage in a way that exposure to the reactive species and free radicals leads to release of iron from the central [4Fe-4S] cluster resulting in the production of the inactive form of Aco2.	Iron	132-136	aconitase 2	Homo sapiens	0-4
28814227-2	2018	Aco2 is highly susceptible to oxidative damage in a way that exposure to the reactive species and free radicals leads to release of iron from the central [4Fe-4S] cluster resulting in the production of the inactive form of Aco2.	Iron	132-136	aconitase 2	Homo sapiens	223-227
29111167-0	2018	Heme oxygenase-1 protects bone marrow mesenchymal stem cells from iron overload through decreasing reactive oxygen species and promoting IL-10 generation.	Iron	66-70	heme oxygenase 1	Mus musculus	0-16
29111167-7	2018	Intracellular iron was down-regulated by hepcidin depending on IL-10.	Iron	14-18	interleukin 10	Mus musculus	63-68
29111167-8	2018	In conclusion, HO-1 protects BMMSCs from ROS by secreting IL-10 upon iron overload.	Iron	69-73	heme oxygenase 1	Mus musculus	15-19
29111167-8	2018	In conclusion, HO-1 protects BMMSCs from ROS by secreting IL-10 upon iron overload.	Iron	69-73	interleukin 10	Mus musculus	58-63
29725502-9	2018	Therefore, the results suggest that CPX-induced degradation of Cdc25A is attributed to the activation of ATR-Chk1 signaling pathway, a consequence of iron chelation-induced DNA damage.	Iron	150-154	ATR serine/threonine kinase	Homo sapiens	105-108
29122992-5	2018	Increases of hepcidin and non-transferrin bound iron levels were visible early in follow-up of all transfusion-dependent patient groups.	Iron	48-52	transferrin	Homo sapiens	30-41
29725502-9	2018	Therefore, the results suggest that CPX-induced degradation of Cdc25A is attributed to the activation of ATR-Chk1 signaling pathway, a consequence of iron chelation-induced DNA damage.	Iron	150-154	checkpoint kinase 1	Homo sapiens	109-113
29231165-4	2018	Low serum vitamin B12 and iron levels could be improved after 20 days using vitamin B12 and iron oral supplements.	Iron	26-30	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	84-87
28859237-2	2018	In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis.	Iron	209-213	interleukin 6	Mus musculus	80-93
28859237-5	2018	A major cause of the systemic iron overload is the reduced iron usage due to suppressed erythropoiesis, which is consistent with an increase in interleukin-6 and reduced expression of erythropoietin.	Iron	30-34	interleukin 6	Mus musculus	144-157
28859237-5	2018	A major cause of the systemic iron overload is the reduced iron usage due to suppressed erythropoiesis, which is consistent with an increase in interleukin-6 and reduced expression of erythropoietin.	Iron	59-63	interleukin 6	Mus musculus	144-157
28859237-6	2018	Importantly, in the liver, absence of CBS caused both a reduction in the transcriptional factor nuclear factor erythroid 2-related factor-2 and an up-regulation of hepcidin that led to a decrease in the iron export protein ferroportin 1.	Iron	203-207	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	223-236
28859237-9	2018	CONCLUSION: Our findings point to a critical role of CBS in iron homeostasis of the body, and the liver in particular; it is likely that a hemochromatosis-like phenotype in patients can be induced by aberration not only in the expression of key molecules in the hepcidin pathway but also of those related to CBS.	Iron	60-64	cystathionine beta-synthase	Homo sapiens	53-56
29231165-4	2018	Low serum vitamin B12 and iron levels could be improved after 20 days using vitamin B12 and iron oral supplements.	Iron	92-96	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	18-21
29376847-8	2018	Furthermore, the iron level in the hippocampus was measured by inductively coupled plasma-mass spectrometry as IL6 is mentioned in several studies to take part in iron homeostasis and inflammation and found to be increased in 5XFAD mice hippocampus.	Iron	17-21	interleukin 6	Mus musculus	111-114
29134616-3	2018	The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation, anemia and iron status parameters.	Iron	151-155	haptoglobin	Homo sapiens	40-47
29376847-8	2018	Furthermore, the iron level in the hippocampus was measured by inductively coupled plasma-mass spectrometry as IL6 is mentioned in several studies to take part in iron homeostasis and inflammation and found to be increased in 5XFAD mice hippocampus.	Iron	163-167	interleukin 6	Mus musculus	111-114
29376857-7	2018	Iron converts native alpha-SYN into a beta-sheet conformation and promotes its aggregation either directly or via increasing levels of oxidative stress.	Iron	0-4	amyloid beta precursor protein	Homo sapiens	36-42
29115635-10	2018	Similarly, challenging cells with either IL-6 or leptin markedly elevated the level of secreted hepcidin (p=0.05) and this was associated with an induction in colonocyte iron levels in both cases.	Iron	170-174	interleukin 6	Homo sapiens	41-45
28775201-0	2018	Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation.	Iron	80-84	renin binding protein	Homo sapiens	68-71
28775201-7	2018	Conclusion: Off-target 18F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation.	Iron	112-116	renin binding protein	Homo sapiens	87-90
28885776-7	2018	Interactions of the carrier ampholytes with the iron of transferrin may prevent iron saturation and thus provide more complicated isoform patterns.	Iron	48-52	transferrin	Homo sapiens	56-67
28885776-7	2018	Interactions of the carrier ampholytes with the iron of transferrin may prevent iron saturation and thus provide more complicated isoform patterns.	Iron	80-84	transferrin	Homo sapiens	56-67
29466169-8	2018	Combined treatment with MEB and IV iron was associated with positive dynamics of Hb, Ht, levels of ferritin, EPO, NT-proBNP, and IL-6.	Iron	35-39	erythropoietin	Homo sapiens	109-112
29466169-8	2018	Combined treatment with MEB and IV iron was associated with positive dynamics of Hb, Ht, levels of ferritin, EPO, NT-proBNP, and IL-6.	Iron	35-39	interleukin 6	Homo sapiens	129-133
28987816-4	2018	The data imply that ASA increases Fpn1 expression by inhibiting hepcidin expression via the IL-6/JAK/STAT3 pathway and show that the reduced content of Ft-L is due to the increased Fpn1 and subsequent iron release in the cells.	Iron	201-205	ferritin light chain 1	Rattus norvegicus	152-156
28987816-5	2018	The reduction of iron in neuronal cells by the increased expression of Fpn1 might be partly associated with the beneficial effects of ASA on mood disorders, AD and PD.	Iron	17-21	solute carrier family 40 member 1	Rattus norvegicus	71-75
29865069-1	2018	Some preclinical and postmortem data report an accumulation of redox-active iron near Abeta plaques.	Iron	76-80	amyloid beta precursor protein	Homo sapiens	86-91
29877248-7	2018	Target genes included those involved in mitochondrial iron metabolism or heme biosynthesis, such as ABCB7 and PPOX, suggesting a role in the abnormal erythropoiesis associated with increased ring sideroblasts.	Iron	54-58	protoporphyrinogen oxidase	Mus musculus	110-114
29173471-12	2018	Fe deficiency increased TIBC and transferrin levels but reduced ferritin and most haematological parameters.	Iron	0-2	transferrin	Rattus norvegicus	33-44
30116274-9	2018	The level of serum IL-8 was significant higher in patients with FE than that of patients with NFE (209.0 pg/mL (ranged: 115-472) vs 65.6 pg/mL (ranged: 11.2-149.3), P=0.008).	Iron	64-66	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
29377837-1	2018	In this paper, a system consisting of acid-washed zero-valent iron (ZVI), ferrous ion (Fe2+), and hydrogen peroxide (H2O2) was employed for the removal of nitrate (NO3-) from water, and the reaction mechanism for this is discussed.	Iron	62-66	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
29377837-1	2018	In this paper, a system consisting of acid-washed zero-valent iron (ZVI), ferrous ion (Fe2+), and hydrogen peroxide (H2O2) was employed for the removal of nitrate (NO3-) from water, and the reaction mechanism for this is discussed.	Iron	68-71	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
28880525-2	2017	Here, we demonstrate that loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase.	Iron	55-59	CDGSH iron sulfur domain 1	Mus musculus	34-42
29284229-10	2017	CONCLUSIONS: Obese women exhibit an increased level of CRP which may affect iron homeostasis.	Iron	76-80	C-reactive protein	Homo sapiens	55-58
28880525-2	2017	Here, we demonstrate that loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase.	Iron	55-59	CDGSH iron sulfur domain 1	Mus musculus	44-49
29228015-7	2017	Intracellularly, CT51 bound iron reversibly and protected against lipid peroxidation.	Iron	28-32	heat shock protein family B (small) member 9	Homo sapiens	17-21
28963052-1	2017	The neurotoxicity of amyloid-beta peptide (Abeta), a predominant histopathological hallmark lesion of Alzheimer"s disease (AD), is enhanced by iron, as found in amyloid plaques of Alzheimer"s disease (AD) patients.	Iron	143-147	amyloid beta precursor protein	Homo sapiens	43-48
29228015-9	2017	These protective properties of CT51 on cellular function highlight its possible therapeutic use in diseases with significant oxidative, iron and calcium dysregulation.	Iron	136-140	heat shock protein family B (small) member 9	Homo sapiens	31-35
29054412-4	2017	In this study, we demonstrate that both iron-poor transferrin (apo-Tf) and the iron chelator, deferoxamine, stimulate release of iron from iron-loaded endothelial cells in an in vitro BBB model.	Iron	40-44	transferrin	Homo sapiens	50-61
29070551-4	2017	Newly absorbed iron binds to plasma transferrin and is distributed around the body to sites of utilization with the erythroid marrow having particularly high iron requirements.	Iron	15-19	transferrin	Homo sapiens	36-47
29070546-4	2017	Key players in mammalian iron trafficking include several types of cells important to iron acquisition, homeostasis, and hematopoiesis (enterocytes, hepatocytes, macrophages, hematopoietic cells, and in the case of pregnancy, placental syncytiotrophoblast cells) and several forms of chaperone proteins, including, for nonheme iron, the transport protein transferrin and the intracellular iron-storage protein ferritin, and for heme iron, the chaperone proteins haptoglobin and hemopexin.	Iron	25-29	transferrin	Homo sapiens	355-366
29292794-6	2017	Moreover, knockdown of p53 resulted in higher non-transferrin-bound iron uptake, which was mediated by increased ZIP14 levels.	Iron	68-72	tumor protein p53	Homo sapiens	23-26
29292794-6	2017	Moreover, knockdown of p53 resulted in higher non-transferrin-bound iron uptake, which was mediated by increased ZIP14 levels.	Iron	68-72	transferrin	Homo sapiens	50-61
29292794-7	2017	Our study highlights a role for p53 in regulating nutrient metabolism and provides insight into how iron and possibly other metals such as zinc and manganese could be regulated in p53-inactivated tumor cells.	Iron	100-104	tumor protein p53	Homo sapiens	32-35
29292794-7	2017	Our study highlights a role for p53 in regulating nutrient metabolism and provides insight into how iron and possibly other metals such as zinc and manganese could be regulated in p53-inactivated tumor cells.	Iron	100-104	tumor protein p53	Homo sapiens	180-183
29313518-1	2017	To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF).	Iron	27-31	transferrin	Homo sapiens	148-159
29313518-1	2017	To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF).	Iron	105-109	transferrin	Homo sapiens	148-159
29313518-1	2017	To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF).	Iron	105-109	transferrin	Homo sapiens	161-163
29313518-1	2017	To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF).	Iron	105-109	transferrin	Homo sapiens	148-159
29313518-1	2017	To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF).	Iron	105-109	transferrin	Homo sapiens	161-163
29313518-6	2017	Reduction of iron bound to TR and LF was assayed with ferrozine.	Iron	13-17	transferrin	Homo sapiens	27-29
29313518-9	2017	The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes.	Iron	64-68	transferrin	Homo sapiens	74-76
29313518-9	2017	The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes.	Iron	93-97	transferrin	Homo sapiens	74-76
29313518-9	2017	The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes.	Iron	93-97	transferrin	Homo sapiens	74-76
29313518-9	2017	The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes.	Iron	93-97	transferrin	Homo sapiens	74-76
29313518-9	2017	The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes.	Iron	93-97	transferrin	Homo sapiens	74-76
29313518-9	2017	The study revealed that enterococci use several ways to acquire iron from TR and LF, such as iron chelating siderophores, iron reduction - facilitated iron release, protein degradation - promoted iron release, and receptor mediated capture of the iron-host protein complexes.	Iron	93-97	transferrin	Homo sapiens	74-76
29126480-2	2017	The developed MCFA system based on simple photometric detection of iron with chromogenic agent (ferrozine) enables a speciation of transferrin (determination of free and Fe-bound protein) in human serum.	Iron	67-71	transferrin	Homo sapiens	131-142
29126480-2	2017	The developed MCFA system based on simple photometric detection of iron with chromogenic agent (ferrozine) enables a speciation of transferrin (determination of free and Fe-bound protein) in human serum.	Iron	170-172	transferrin	Homo sapiens	131-142
28342014-0	2017	Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet.	Iron	69-73	transferrin	Homo sapiens	27-38
28888833-1	2017	Iron depletion (ID) has been shown to induce the liver expression of Cyp7a1, the rate-limiting enzyme initiating conversion of cholesterol to bile acids (BA), although the effect on bile acids metabolism and bile production is unknown.	Iron	0-4	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	69-75
28888833-8	2017	Experiments with differentiated human hepatic HepaRG cells confirmed human CYP7A1 orthologue upregulation resulting from reduced iron concentrations.	Iron	129-133	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	75-81
29063293-0	2017	Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.	Iron	68-72	mechanistic target of rapamycin kinase	Homo sapiens	4-8
29063293-0	2017	Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.	Iron	68-72	peroxiredoxin 2	Homo sapiens	35-40
29063293-4	2017	Here we explored the effects of mechanistic target of rapamycin (mTOR) inhibition in iron-stressed human neuroblastoma cells.	Iron	85-89	mechanistic target of rapamycin kinase	Homo sapiens	32-63
29063293-4	2017	Here we explored the effects of mechanistic target of rapamycin (mTOR) inhibition in iron-stressed human neuroblastoma cells.	Iron	85-89	mechanistic target of rapamycin kinase	Homo sapiens	65-69
29063293-5	2017	Two mTOR inhibitors, rapamycin and Torin 1, had similar effects in cells exposed to a relatively low concentration of iron.	Iron	118-122	mechanistic target of rapamycin kinase	Homo sapiens	4-8
29063293-5	2017	Two mTOR inhibitors, rapamycin and Torin 1, had similar effects in cells exposed to a relatively low concentration of iron.	Iron	118-122	peroxiredoxin 2	Homo sapiens	35-40
29063293-6	2017	At a higher concentration of iron, Torin 1, instead of rapamycin, could further aggravate iron-induced cytotoxicity, and mitochondrial ROS levels were significantly higher in Torin 1-treated cells.	Iron	29-33	peroxiredoxin 2	Homo sapiens	35-40
29063293-6	2017	At a higher concentration of iron, Torin 1, instead of rapamycin, could further aggravate iron-induced cytotoxicity, and mitochondrial ROS levels were significantly higher in Torin 1-treated cells.	Iron	29-33	peroxiredoxin 2	Homo sapiens	175-180
29063293-6	2017	At a higher concentration of iron, Torin 1, instead of rapamycin, could further aggravate iron-induced cytotoxicity, and mitochondrial ROS levels were significantly higher in Torin 1-treated cells.	Iron	90-94	peroxiredoxin 2	Homo sapiens	35-40
29070546-4	2017	Key players in mammalian iron trafficking include several types of cells important to iron acquisition, homeostasis, and hematopoiesis (enterocytes, hepatocytes, macrophages, hematopoietic cells, and in the case of pregnancy, placental syncytiotrophoblast cells) and several forms of chaperone proteins, including, for nonheme iron, the transport protein transferrin and the intracellular iron-storage protein ferritin, and for heme iron, the chaperone proteins haptoglobin and hemopexin.	Iron	25-29	haptoglobin	Homo sapiens	462-473
29070551-5	2017	Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane.	Iron	0-4	transferrin	Homo sapiens	12-23
29070551-5	2017	Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane.	Iron	0-4	transferrin	Homo sapiens	33-44
29070551-5	2017	Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane.	Iron	129-133	transferrin	Homo sapiens	12-23
29070551-5	2017	Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane.	Iron	129-133	transferrin	Homo sapiens	33-44
29070551-7	2017	Cellular iron concentrations are modulated by the iron regulatory proteins (IRPs) IRP1 and IRP2.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	91-95
28912144-14	2017	Conclusion:18F-FDHT and 18F-FES uptake correlate well with AR and ER expression levels in representative biopsies.	Iron	28-31	androgen receptor	Homo sapiens	59-61
28836730-5	2017	Two larger-scale trials confirming these results (FAIR-HF and CONFIRM-HF) have led to guideline recommendations that IV iron therapy should be considered in patients with CHF with reduced ejection fraction and iron deficiency (serum ferritin &lt;100 mug/L, or ferritin between 100 and 299 mug/L with transferrin saturation &lt;20%) to provide symptomatic relief and improve exercise capacity and quality of life.	Iron	120-124	transferrin	Homo sapiens	300-311
27484685-9	2017	CONCLUSIONS: Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.	Iron	23-27	adiponectin, C1Q and collagen domain containing	Homo sapiens	156-167
28851597-0	2017	Intraspinal TLR4 activation promotes iron storage but does not protect neurons or oligodendrocytes from progressive iron-mediated damage.	Iron	37-41	toll-like receptor 4	Mus musculus	12-16
28851597-5	2017	Peripherally, toll-like receptor 4 (TLR4) activation promotes iron sequestration by macrophages.	Iron	62-66	toll-like receptor 4	Mus musculus	14-34
28851597-5	2017	Peripherally, toll-like receptor 4 (TLR4) activation promotes iron sequestration by macrophages.	Iron	62-66	toll-like receptor 4	Mus musculus	36-40
28851597-6	2017	Notably, iron-rich sites of CNS pathology typically contain TLR4 agonists, which may promote iron uptake.	Iron	9-13	toll-like receptor 4	Mus musculus	60-64
29079528-2	2017	Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense.	Iron	78-82	transferrin	Homo sapiens	0-15
29079528-2	2017	Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense.	Iron	78-82	telomeric repeat binding factor 1	Homo sapiens	17-20
28833753-11	2017	Iron-saturated Lf (holo-Lf) increased TE expression and promoted Akt1 phosphorylation, when compared to those parameters in cells treated with iron-free Lf (apo-Lf).	Iron	0-4	AKT serine/threonine kinase 1	Homo sapiens	65-69
28986474-8	2017	In CYP3A4, the most energetically favorable docking mode places testosterone in a position with the methyl groups directed toward the heme iron, which is more favorable for oxidation at C6beta, whereas for CYP3A7 the testosterone methyl groups are positioned away from the heme, which is more favorable for an oxidation event at C2alpha In conclusion, our data indicate an alternative binding mode for testosterone in CYP3A7 that favors the 2alpha-hydroxylation, suggesting significant structural differences in its active site compared with CYP3A4/5.	Iron	139-143	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	3-9
28986474-8	2017	In CYP3A4, the most energetically favorable docking mode places testosterone in a position with the methyl groups directed toward the heme iron, which is more favorable for oxidation at C6beta, whereas for CYP3A7 the testosterone methyl groups are positioned away from the heme, which is more favorable for an oxidation event at C2alpha In conclusion, our data indicate an alternative binding mode for testosterone in CYP3A7 that favors the 2alpha-hydroxylation, suggesting significant structural differences in its active site compared with CYP3A4/5.	Iron	139-143	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	206-212
28986474-8	2017	In CYP3A4, the most energetically favorable docking mode places testosterone in a position with the methyl groups directed toward the heme iron, which is more favorable for oxidation at C6beta, whereas for CYP3A7 the testosterone methyl groups are positioned away from the heme, which is more favorable for an oxidation event at C2alpha In conclusion, our data indicate an alternative binding mode for testosterone in CYP3A7 that favors the 2alpha-hydroxylation, suggesting significant structural differences in its active site compared with CYP3A4/5.	Iron	139-143	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	418-424
28986474-8	2017	In CYP3A4, the most energetically favorable docking mode places testosterone in a position with the methyl groups directed toward the heme iron, which is more favorable for oxidation at C6beta, whereas for CYP3A7 the testosterone methyl groups are positioned away from the heme, which is more favorable for an oxidation event at C2alpha In conclusion, our data indicate an alternative binding mode for testosterone in CYP3A7 that favors the 2alpha-hydroxylation, suggesting significant structural differences in its active site compared with CYP3A4/5.	Iron	139-143	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	542-548
28818478-0	2017	Mutations in DDHD1, encoding a phospholipase A1, is a novel cause of retinopathy and neurodegeneration with brain iron accumulation.	Iron	114-118	DDHD domain containing 1	Homo sapiens	13-18
28818478-4	2017	Here we report a complex form of HSP associated with retinal dystrophy and a pattern of neurodegeneration with brain iron accumulation (NBIA) on brain MRI, due to a novel homozygous mutation in DDHD1.	Iron	117-121	DDHD domain containing 1	Homo sapiens	194-199
28851597-6	2017	Notably, iron-rich sites of CNS pathology typically contain TLR4 agonists, which may promote iron uptake.	Iron	93-97	toll-like receptor 4	Mus musculus	60-64
28851597-8	2017	Here we used a reductionist model to ask if TLR4 activation in the CNS stimulates iron uptake and promotes neuroprotection from iron-induced toxicity.	Iron	82-86	toll-like receptor 4	Mus musculus	44-48
28851597-8	2017	Here we used a reductionist model to ask if TLR4 activation in the CNS stimulates iron uptake and promotes neuroprotection from iron-induced toxicity.	Iron	128-132	toll-like receptor 4	Mus musculus	44-48
28851597-10	2017	Results show that, similar to the periphery, activating intraspinal TLR4 via focal LPS injection increased mRNA encoding iron uptake and storage proteins and promoted iron sequestration into ferritin-expressing macrophages.	Iron	121-125	toll-like receptor 4	Mus musculus	68-72
28851597-10	2017	Results show that, similar to the periphery, activating intraspinal TLR4 via focal LPS injection increased mRNA encoding iron uptake and storage proteins and promoted iron sequestration into ferritin-expressing macrophages.	Iron	167-171	toll-like receptor 4	Mus musculus	68-72
28851597-12	2017	Moreover, replacement of oligodendrocytes by progenitor cells - a normally robust response to in vivo macrophage TLR4 activation - was significantly reduced if iron was present concomitant with TLR4 activation.	Iron	160-164	toll-like receptor 4	Mus musculus	113-117
28851597-13	2017	Thus, while TLR4 signaling promotes CNS iron uptake, future work needs to determine ways to enhance iron removal without blocking the reparative effects of innate immune receptor signaling.	Iron	40-44	toll-like receptor 4	Mus musculus	12-16
29107744-3	2017	In this study, NBD-Pen was used to detect lipid-derived radicals in Ox-LDL from in vitro and in vivo samples using an iron overloaded mouse model.	Iron	118-122	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	19-22
29101207-5	2017	This leads to progressive and preferential iron trapping in tissue macrophages, reduced iron release to serum transferrin (i.e. inappropriately low transferrin saturation) and a tendency towards anemia at menarche or after intense bloodletting.	Iron	88-92	transferrin	Homo sapiens	110-121
28784700-6	2017	Macrophages cultured in high-iron conditions had reduced responses to Toll-like receptor-2, -3, and -4 agonists, which associated with decreased reactive oxygen species production, increased nuclear localization of the NRF2 transcription factor, increased expression of the NRF2-related antioxidant response genes, and limited NF-kappaB and proinflammatory signaling.	Iron	29-33	toll like receptor 2	Homo sapiens	70-102
28784700-6	2017	Macrophages cultured in high-iron conditions had reduced responses to Toll-like receptor-2, -3, and -4 agonists, which associated with decreased reactive oxygen species production, increased nuclear localization of the NRF2 transcription factor, increased expression of the NRF2-related antioxidant response genes, and limited NF-kappaB and proinflammatory signaling.	Iron	29-33	NFE2 like bZIP transcription factor 2	Homo sapiens	219-223
28784700-6	2017	Macrophages cultured in high-iron conditions had reduced responses to Toll-like receptor-2, -3, and -4 agonists, which associated with decreased reactive oxygen species production, increased nuclear localization of the NRF2 transcription factor, increased expression of the NRF2-related antioxidant response genes, and limited NF-kappaB and proinflammatory signaling.	Iron	29-33	NFE2 like bZIP transcription factor 2	Homo sapiens	274-278
27019150-6	2017	Calcium and magnesium intake were significantly higher in patients with RLS inversely iron intake was higher in patients without RLS.	Iron	86-90	RLS1	Homo sapiens	72-75
27019150-11	2017	Severity of RLS decreased by iron intake and increased by magnesium intake.	Iron	29-33	RLS1	Homo sapiens	12-15
27019150-13	2017	Lower hemoglobin levels and supplementation of iron are the independent predictors for severity of RLS in pregnant women.	Iron	47-51	RLS1	Homo sapiens	99-102
29158016-3	2017	For most HC forms (types 1, 2, 3 and 4B HC) iron overload is related to cellular hepcidin deprivation which causes an increase of plasma iron concentration and the appearance of plasma non-transferrin bound iron.	Iron	44-48	transferrin	Homo sapiens	189-200
29098639-2	2017	Tef is a gluten free cereal and contains the highest iron and calcium among other cereals.	Iron	53-57	TEF transcription factor, PAR bZIP family member	Homo sapiens	0-3
29098639-5	2017	There are significantly conflicting reports of iron content of tef ranging from 5 to 150 mg/100 g dm.	Iron	47-51	TEF transcription factor, PAR bZIP family member	Homo sapiens	63-66
28582740-4	2017	Our results show that there is a strong positive relationship between runoff and the concentration of NO3-N, Mn and Fe in agricultural catchments.	Iron	116-118	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
28599363-5	2017	Nano-enabled sorbents with iron or titanium nanoparticles embedded inside the porous structure of an anion exchange resin demonstrated high ability to remove both pollutants simultaneously despite competition, with the tested sorbents showing 11mumol/g capacity for Cr(VI) and 19mumol/g for As(V) in simulated groundwater on average.	Iron	27-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	291-296
29184091-6	2017	Subsequently, a sample of ~1.9 billion-year-old microfossil from the Gunflint Formation in Canada is investigated, and for the first time ever, we are able to locally identify the oxidation state of iron compounds encrusting the 5 to 10 mum microfossils.	Iron	199-203	latexin	Homo sapiens	237-240
29191165-7	2017	Any patients will eventually require treatment with erythropoietin or similar products that are given by injection.Over the last few years, several iron and erythropoietin products have been licensed for treating anaemia in chronic kidney disease patients.	Iron	148-152	erythropoietin	Homo sapiens	52-66
29028491-5	2017	Extremely high dosages (&gt; 9000 mg/L or 333 mM Al and 160 mM Fe) corresponding to Al/B and Fe/B mass ratios of ~70 and molar ratios of ~28 and 13 respectively were necessary to remove ~80% boron.	Iron	63-65	albumin	Homo sapiens	84-88
28482461-1	2017	The kinetics and mechanisms of the reduction of NO3- in solution to NH3 by 1.5mum diameter zero-valent iron (ZVI1.5) particles has been examined.	Iron	103-107	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
29017326-0	2017	Mechanism of Nakamura"s Bisphosphine-Iron-Catalyzed Asymmetric C(sp2)-C(sp3) Cross-Coupling Reaction: The Role of Spin in Controlling Arylation Pathways.	Iron	37-41	Sp2 transcription factor	Homo sapiens	63-68
29017326-1	2017	Quantum mechanical calculations are employed to investigate the mechanism and origin of stereoinduction in asymmetric iron-catalyzed C(sp2)-C(sp3) cross-coupling reaction between Grignard reagents and alpha-chloroesters.	Iron	118-122	Sp2 transcription factor	Homo sapiens	133-138
29111022-1	2017	BACKGROUND AND PURPOSE: The objective of this work was to investigate whether patients with and without freezing of gait (FOG) in Parkinson"s disease (PD) have differences in iron accumulation in substantia nigra using R2* relaxometry.	Iron	175-179	zinc finger protein, FOG family member 1	Homo sapiens	122-125
29111022-6	2017	Within PD subgroups, FOG (+) group had increased iron accumulation in SNc compared to FOG (-) and HC.	Iron	49-53	zinc finger protein, FOG family member 1	Homo sapiens	21-24
29078380-0	2017	Large G protein alpha-subunit XLalphas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.	Iron	97-101	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	0-7
29111022-8	2017	CONCLUSIONS: Our study reveals higher nigral iron content in FOG (+) compared to FOG (-) and HCs.	Iron	45-49	zinc finger protein, FOG family member 1	Homo sapiens	61-64
29111022-9	2017	In addition, we observed positive correlation of FOG score with iron accumulation in SNc.	Iron	64-68	zinc finger protein, FOG family member 1	Homo sapiens	49-52
29111022-10	2017	Results of this study emphasize possible role of higher nigral iron content in the pathogenesis of FOG in PD.	Iron	63-67	zinc finger protein, FOG family member 1	Homo sapiens	99-102
29097764-7	2017	CP value of SN in PD group was significantly and negatively correlated with interleukin-1beta level in CSF, so interleukin-1beta might be a neuroinflammatory factor produced by excessive iron in SN.	Iron	187-191	interleukin 1 beta	Homo sapiens	111-128
29163511-10	2017	Overall, it is clear that while the ability of LTF to both sequester iron and to direct reactive oxygen intermediates is a major factor in lessening damage due to excessive inflammatory responses, further effects are apparent through direct control over development of higher order immune functions that regulate pathology due to insult and injury.	Iron	69-73	lactotransferrin	Homo sapiens	47-50
29151689-10	2017	While earliest morphological signs of inflammation in liver were visible after 6 h, increased expression of the two acute-phase cytokines IFN-gamma (1h) and IL-1beta (3h) was detectable earlier, with maximum values after 12-24 h. Iron concentrations in liver tissue increased steadily between 1 h and 48 h, and remained high at 96 h. In contrast, spleen iron concentrations remained unchanged until 48 h, and increased mildly thereafter (96 h).	Iron	230-234	interleukin 1 beta	Rattus norvegicus	157-165
28848044-9	2017	The formation of this subcomplex was critical for conferring stability to the NEFs, helped fine-tune mitochondrial protein quality control, and regulated crucial mtHsp70 functions, such as import of preproteins and biogenesis of Fe-S clusters.	Iron	229-233	heat shock protein family A (Hsp70) member 9	Homo sapiens	162-169
28815688-3	2017	Here, we show that dietary iron loading has a residual ability to induce Smad signaling and hepcidin expression in Bmp6-/- mice, effects that are blocked by a neutralizing BMP2/4 antibody.	Iron	27-31	bone morphogenetic protein 2	Mus musculus	172-178
28815688-0	2017	Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6.	Iron	38-42	bone morphogenetic protein 2	Mus musculus	0-28
29024122-3	2017	Using a combination of scanning tunneling microscopy and density functional theory, it is shown that the binding of iron phthalocyanine (FePc) molecules is mediated via the strong chemisorption of the central Fe atom to the sp3 -like dangling bond of Si atoms in the linear silicene domain boundaries.	Iron	137-139	Sp3 transcription factor	Homo sapiens	224-227
28815688-4	2017	Moreover, BMP2/4 antibody inhibits hepcidin expression and induces iron loading in wildtype mice, whereas a BMP4 antibody has no effect.	Iron	67-71	bone morphogenetic protein 2	Mus musculus	10-16
28815688-5	2017	Bmp2 mRNA is predominantly expressed in endothelial cells of the liver, where its baseline expression is higher, but its induction by iron is less robust than Bmp6.	Iron	134-138	bone morphogenetic protein 2	Mus musculus	0-4
28815688-6	2017	Mice with a conditional ablation of Bmp2 in endothelial cells exhibit hepcidin deficiency, serum iron overload, and tissue iron loading in liver, pancreas and heart, with reduced spleen iron.	Iron	97-101	bone morphogenetic protein 2	Mus musculus	36-40
28815688-6	2017	Mice with a conditional ablation of Bmp2 in endothelial cells exhibit hepcidin deficiency, serum iron overload, and tissue iron loading in liver, pancreas and heart, with reduced spleen iron.	Iron	123-127	bone morphogenetic protein 2	Mus musculus	36-40
28960803-3	2017	DDX11 encodes an iron-sulfur-containing DNA helicase, and mutations in this gene have been reported in the five WABS cases previously identified to date.	Iron	17-21	DEAD/H-box helicase 11	Homo sapiens	0-5
28815688-6	2017	Mice with a conditional ablation of Bmp2 in endothelial cells exhibit hepcidin deficiency, serum iron overload, and tissue iron loading in liver, pancreas and heart, with reduced spleen iron.	Iron	123-127	bone morphogenetic protein 2	Mus musculus	36-40
28815688-7	2017	Together, these data demonstrate that in addition to BMP6, endothelial cell BMP2 has a non-redundant role in hepcidin regulation by iron.	Iron	132-136	bone morphogenetic protein 2	Mus musculus	76-80
28555756-1	2017	Matriptase-2 plays a pivotal role in keeping iron concentrations within a narrow physiological range in humans.	Iron	45-49	transmembrane serine protease 6	Homo sapiens	0-12
28971232-2	2017	Transferrin (Tf) is the major iron-transporting protein in the human body and, for this reason, has been extensively studied in biomedicine.	Iron	30-34	transferrin	Homo sapiens	0-11
28670831-0	2017	Varying iron release from transferrin and lactoferrin proteins.	Iron	8-12	transferrin	Homo sapiens	26-37
28670831-4	2017	The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf).	Iron	51-55	transferrin	Homo sapiens	121-132
28670831-4	2017	The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf).	Iron	51-55	transferrin	Homo sapiens	134-136
28670831-4	2017	The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf).	Iron	98-102	transferrin	Homo sapiens	121-132
28670831-5	2017	Despite having very similar structures and iron-binding sites, Tf releases practically all its iron at pH 5.5 while Lf requires a significantly lower pH of 3.	Iron	43-47	transferrin	Homo sapiens	63-65
28670831-5	2017	Despite having very similar structures and iron-binding sites, Tf releases practically all its iron at pH 5.5 while Lf requires a significantly lower pH of 3.	Iron	95-99	transferrin	Homo sapiens	63-65
28670831-6	2017	This difference in behavior is directly related to their respective biological functions as Tf blood-borne iron into the cell, while Lf competes with pathogens to sequester iron in biological fluids at more acidic pHs.	Iron	107-111	transferrin	Homo sapiens	92-94
28670831-7	2017	During this experiment, the students will carry out iron loading and unloading on both human Lf and Tf and monitor the iron release at different pHs using UV-Vis spectroscopy.	Iron	52-56	transferrin	Homo sapiens	100-102
28670831-8	2017	With this simple approach, the students will discover the different patterns of iron release of Tf and Lf and how this variance in behavior relates to their biological functions.	Iron	80-84	transferrin	Homo sapiens	96-98
28755795-8	2017	Hereby, transferrin protects the host against the reactive oxygen species that can be formed as a consequence of free iron.	Iron	118-122	transferrin	Homo sapiens	8-19
28755795-11	2017	This review summarizes the preclinical and clinical data on the efficacy of exogenous transferrin administration to modulate certain forms of anemia and to prevent the toxic effects of free iron.	Iron	190-194	transferrin	Homo sapiens	86-97
28514321-2	2017	New intravenous iron formulations allow infusion of higher doses, increasing EPO response.	Iron	16-20	erythropoietin	Homo sapiens	77-80
28755795-0	2017	Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity.	Iron	68-72	transferrin	Homo sapiens	19-30
28755795-1	2017	As the main iron transporter, transferrin delivers iron to target tissues like the bone marrow for erythropoiesis.	Iron	12-16	transferrin	Homo sapiens	30-41
28755795-2	2017	Also, by binding free iron, transferrin prevents formation of reactive oxygen species.	Iron	22-26	transferrin	Homo sapiens	28-39
28755795-5	2017	First, transferrin can correct anemia by modulating the amount of iron that is available for erythropoiesis.	Iron	66-70	transferrin	Homo sapiens	7-18
28755795-7	2017	Second, under conditions of iron overload, transferrin reduces oxidative stress by binding free iron in the circulation and in tissues.	Iron	28-32	transferrin	Homo sapiens	43-54
28755795-7	2017	Second, under conditions of iron overload, transferrin reduces oxidative stress by binding free iron in the circulation and in tissues.	Iron	96-100	transferrin	Homo sapiens	43-54
28555756-2	2017	The opportunity to reduce matriptase-2 proteolytic activity may open a novel possibility to treat iron overload diseases, such as hereditary hemochromatosis and thalassemia.	Iron	98-102	transmembrane serine protease 6	Homo sapiens	26-38
29297116-1	2017	The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated.	Iron	60-64	myeloperoxidase	Homo sapiens	156-171
29227261-5	2017	The higher doses of erythropoietin and their fluctuation and the fluctuation in dose of iron drugs were observed in the group of patients with middle degree anemia.	Iron	88-92	erythropoietin	Homo sapiens	20-34
28669019-11	2017	Moreover, hepatic expression of hepcidin, a regulator of iron homeostasis, did not differ between the control and CKD groups.	Iron	57-61	hepcidin antimicrobial peptide	Rattus norvegicus	32-40
29297116-1	2017	The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated.	Iron	60-64	myeloperoxidase	Homo sapiens	173-176
28894019-2	2017	Here, we characterize an Arabidopsis (Arabidopsis thaliana) double mutant, yellow stripe1-like yellow stripe3-like (ysl1ysl3), which has lost the ability to properly regulate iron deficiency-influenced gene expression in both roots and shoots.	Iron	175-179	YELLOW STRIPE like 1	Arabidopsis thaliana	116-124
29073555-2	2017	A synergistic anion as carbonate is an anion that is required for iron binding by transferrin while non-synergistic anions do not act as the synergistic anions to promote iron binding, but affect the iron binding and release.	Iron	66-70	transferrin	Homo sapiens	82-93
29073555-4	2017	In the present work, molecular dynamic simulation techniques were employed in order to gain access into a molecular level understanding of the iron binding site of the human serum transferrin during the synergistic and non-synergistic anion binding.	Iron	143-147	transferrin	Homo sapiens	180-191
29073555-7	2017	Meanwhile,the simulation of the open (Apo), partially closed (Carbonate) and fully closed (Carbonate-Fe) forms of the transferrin structure allows a direct comparison between the iron binding site of these three states.On the basis of results, synergistic anions form high affinity binding site, while non-synergistic anions act like Apo state of the transferrin structure and change the proper conformation of the binding site.	Iron	101-103	transferrin	Homo sapiens	118-129
29073555-7	2017	Meanwhile,the simulation of the open (Apo), partially closed (Carbonate) and fully closed (Carbonate-Fe) forms of the transferrin structure allows a direct comparison between the iron binding site of these three states.On the basis of results, synergistic anions form high affinity binding site, while non-synergistic anions act like Apo state of the transferrin structure and change the proper conformation of the binding site.	Iron	179-183	transferrin	Homo sapiens	118-129
28803783-3	2017	LIAS is an iron-sulfur (Fe-S) cluster-containing mitochondrial protein, like mitochondrial aconitase (mt-aco) and some subunits of respiratory chain (RC) complexes I, II and III.	Iron	24-28	aconitase 2	Homo sapiens	77-100
29073555-0	2017	Effects of synergistic and non-synergistic anions on the iron binding site from serum transferrin: A molecular dynamic simulation analysis.	Iron	57-61	transferrin	Homo sapiens	86-97
28678636-5	2017	In p.C282Y homozygous men, but not in homozygous women, we found that the presence of two HLA-A*03 alleles increased the iron load on average by approximately 2-fold compared to p.C282Y homozygous men carrying zero or one A*03 allele.	Iron	121-125	major histocompatibility complex, class I, A	Homo sapiens	90-95
28849262-10	2017	Differences in the integrated intensity of the EPR signal from transferrin translate directly into the amount of bound iron.	Iron	119-123	transferrin	Homo sapiens	63-74
28678636-6	2017	On the other hand, the presence of two HLA-A*01 alleles, in male subjects, apparently reduced the iron loading.	Iron	98-102	major histocompatibility complex, class I, A	Homo sapiens	39-44
28678636-7	2017	In p.C282Y homozygous individuals, the iron loading was increased if the CD8 + cell number was below the 25 percentile or if the CD4 + cell number was above the 75 percentile.	Iron	39-43	CD4 molecule	Homo sapiens	129-132
28678636-9	2017	Our data indicate that homozygosity for the HLA-A*03 allele significantly increases the risk of excessive iron loading in Norwegian p.C282Y homozygous male patients.	Iron	106-110	major histocompatibility complex, class I, A	Homo sapiens	44-49
28678636-10	2017	In addition, low CD8 + cell number or high CD4 + cell number further increases the risk of excessive iron loading.	Iron	101-105	CD4 molecule	Homo sapiens	43-46
28864815-4	2017	Clinically achievable concentrations (1 microM) progressively mobilized cellular iron from hepatocyte, cardiomyocyte, and pancreatic cell lines, rapidly decreasing intracellular reactive oxygen species (ROS) and also restoring insulin secretion in pancreatic cells.	Iron	81-85	insulin	Homo sapiens	227-234
29168708-0	2017	Preparation of magnetic carbon/Fe3O4 supported zero-valent iron composites and their application in Pb(II) removal from aqueous solutions.	Iron	59-63	submaxillary gland androgen regulated protein 3B	Homo sapiens	100-106
29093761-12	2017	However, a three-way interaction between SLC30A8 genotype, BMI, and zinc to iron ratio was observed (Pinteraction = 0.007).	Iron	76-80	solute carrier family 30 member 8	Homo sapiens	41-48
29093761-14	2017	Conclusions: Zinc supplementation and a high zinc to iron intake ratio may lower the risk of T2D, but these associations could be modified by obesity and the SLC30A8 genotype.	Iron	53-57	solute carrier family 30 member 8	Homo sapiens	158-165
29061112-2	2017	Iron homeostasis is maintained by iron regulatory proteins (IRP1 and IRP2) and the iron-responsive element (IRE) signaling pathway.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	69-73
29061112-6	2017	The levels of alpha-Syn, APP and amyloid beta-peptide (Abeta) as well as protein aggregation can be down-regulated by IRPs but are up-regulated in the presence of iron accumulation.	Iron	163-167	amyloid beta precursor protein	Homo sapiens	55-60
28847921-0	2017	A Bacterial Multidomain NAD-Independent d-Lactate Dehydrogenase Utilizes Flavin Adenine Dinucleotide and Fe-S Clusters as Cofactors and Quinone as an Electron Acceptor for d-Lactate Oxidization.	Iron	105-109	FAD-binding oxidoreductase	Pseudomonas putida KT2440	40-63
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	57-61	transferrin	Homo sapiens	4-15
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	111-115	transferrin	Homo sapiens	4-15
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	111-115	transferrin	Homo sapiens	4-15
28815927-0	2017	Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization.	Iron	36-40	transferrin	Homo sapiens	60-71
28815927-5	2017	The larger change of SAXS shapes between Tf+C60 (OH)22 and Tf+FeCl3 implies that C60 (OH)22 is bound to Tf, blocking the iron-binding site.	Iron	121-125	transferrin	Homo sapiens	41-43
28815927-5	2017	The larger change of SAXS shapes between Tf+C60 (OH)22 and Tf+FeCl3 implies that C60 (OH)22 is bound to Tf, blocking the iron-binding site.	Iron	121-125	transferrin	Homo sapiens	59-61
28815927-5	2017	The larger change of SAXS shapes between Tf+C60 (OH)22 and Tf+FeCl3 implies that C60 (OH)22 is bound to Tf, blocking the iron-binding site.	Iron	121-125	transferrin	Homo sapiens	59-61
28815927-6	2017	The larger deviation of the SAXS shape from a possible crystal structure of Tf tetramer implies that Gd@C82 (OH)22 is bound to the Tf tetramer, thus disturbing iron transport.	Iron	160-164	transferrin	Homo sapiens	76-78
28815927-6	2017	The larger deviation of the SAXS shape from a possible crystal structure of Tf tetramer implies that Gd@C82 (OH)22 is bound to the Tf tetramer, thus disturbing iron transport.	Iron	160-164	transferrin	Homo sapiens	131-133
29046740-5	2017	E. coli BG1 belonged to the serotype O159:H21, was classified in the phylogroup B1 and possessed the genetic information encoding "virulence factors" such as adherence systems, iron acquisition and flagella synthesis.	Iron	177-181	acyl-CoA synthetase bubblegum family member 1	Bos taurus	8-11
29036914-9	2017	Taken together, our results suggest that the ferritin heavy chain subunit from eri-silkworm may play critical roles not only in innate immune defense, but also in organismic iron homeostasis.	Iron	174-178	ferritin	Bombyx mori	45-53
28726133-1	2017	While the administration of antivenom to treat hemotoxic snake bite injury remains the gold standard of therapy, we have demonstrated that modifying human fibrinogen with iron and carbon monoxide renders it resistant to fibrinogenolytic snake venom enzymes.	Iron	171-175	fibrinogen beta chain	Homo sapiens	155-165
29159215-3	2017	Cysteine desulfurase (Nfs1) is required generation of a form of activated sulfur and is essential for the initial Fe-S cluster assembly step.	Iron	114-118	cysteine desulfurase	Saccharomyces cerevisiae S288C	22-26
28711740-1	2017	Mutations in WDR45 are responsible for beta-propeller protein-associated neurodegeneration (BPAN), which is an X-linked form of neurodegeneration with brain iron accumulation.	Iron	157-161	WD repeat domain 45	Homo sapiens	13-18
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	16-20	immunoglobulin kappa variable 1-16	Homo sapiens	136-139
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	16-20	immunoglobulin kappa variable 1-16	Homo sapiens	164-167
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	100-104	immunoglobulin kappa variable 1-16	Homo sapiens	136-139
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	100-104	immunoglobulin kappa variable 1-16	Homo sapiens	164-167
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	100-104	immunoglobulin kappa variable 1-16	Homo sapiens	136-139
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	100-104	immunoglobulin kappa variable 1-16	Homo sapiens	164-167
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	100-104	immunoglobulin kappa variable 1-16	Homo sapiens	136-139
28672722-4	2017	The increase in iron initial concentration was found to be detrimental, since the natural amount of iron present in the effluent, 73 mg L-1 of total iron and 61 mg L-1 of dissolved iron, was sufficient to ensure the electro-Fenton process at the applied intensities - 0.2-1.4 A.	Iron	100-104	immunoglobulin kappa variable 1-16	Homo sapiens	164-167
28370178-2	2017	Hepcidin is upregulated during inflammation through the activation of the signal transducer and activator of transcription 3 (STAT3) transduction pathway, which decreases iron bioavailability and may explain the anemia of chronic inflammatory disease.	Iron	171-175	signal transducer and activator of transcription 3	Homo sapiens	74-124
28370178-2	2017	Hepcidin is upregulated during inflammation through the activation of the signal transducer and activator of transcription 3 (STAT3) transduction pathway, which decreases iron bioavailability and may explain the anemia of chronic inflammatory disease.	Iron	171-175	signal transducer and activator of transcription 3	Homo sapiens	126-131
28506129-7	2017	After 3 months of oral iron treatment, there was a significant improvement (decrease) in urinary NGAL and L-FABP in infants and children with IDA.	Iron	23-27	fatty acid binding protein 1	Homo sapiens	106-112
28642302-2	2017	Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis.	Iron	29-33	transferrin	Homo sapiens	11-22
28642302-2	2017	Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis.	Iron	80-84	transferrin	Homo sapiens	11-22
28642302-2	2017	Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis.	Iron	80-84	transferrin	Homo sapiens	11-22
28642302-12	2017	In conclusion, high transferrin iron utilization, relative to the transfusion-iron load rate, decreases the risk of cardiosiderosis.	Iron	32-36	transferrin	Homo sapiens	20-31
28447549-2	2017	We suspected IRIDA, iron-refractory iron-deficiency anemia, a genetic iron metabolism disorder, caused by TMPRSS6 variations.	Iron	20-24	transmembrane serine protease 6	Homo sapiens	106-113
28775066-3	2017	At the cellular level, iron homeostasis is dependent on the iron regulatory proteins IRP1/IRP2.	Iron	23-27	iron responsive element binding protein 2	Homo sapiens	90-94
29049732-4	2017	The purpose of this work was to explore iron chelation therapy for improving cone survival and function in the rd10 mouse model of RP.	Iron	40-44	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	111-115
28775066-3	2017	At the cellular level, iron homeostasis is dependent on the iron regulatory proteins IRP1/IRP2.	Iron	60-64	iron responsive element binding protein 2	Homo sapiens	90-94
28500782-11	2017	Further study uncovered that melatonin inhibited the upregulation of p53, ERK and p38 protein expressions in BMSCs with iron overload.	Iron	120-124	tumor protein p53	Homo sapiens	69-72
28500782-11	2017	Further study uncovered that melatonin inhibited the upregulation of p53, ERK and p38 protein expressions in BMSCs with iron overload.	Iron	120-124	mitogen-activated protein kinase 1	Homo sapiens	74-77
28500782-11	2017	Further study uncovered that melatonin inhibited the upregulation of p53, ERK and p38 protein expressions in BMSCs with iron overload.	Iron	120-124	mitogen-activated protein kinase 14	Homo sapiens	82-85
28500782-12	2017	Collectively, melatonin plays a protective role in iron overload-induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation.	Iron	51-55	tumor protein p53	Homo sapiens	165-168
28500782-12	2017	Collectively, melatonin plays a protective role in iron overload-induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation.	Iron	51-55	mitogen-activated protein kinase 1	Homo sapiens	169-172
28500782-12	2017	Collectively, melatonin plays a protective role in iron overload-induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation.	Iron	51-55	mitogen-activated protein kinase 14	Homo sapiens	173-176
28390898-7	2017	Yeast one-hybrid analysis showed that ERF72 could directly bind to the promoter regions of iron deficiency responses genes IRT1, HA2 and CLH1.	Iron	91-95	chlorophyllase 1	Arabidopsis thaliana	137-141
28768766-0	2017	A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.	Iron	62-66	F-box and leucine rich repeat protein 5	Homo sapiens	31-36
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	36-40	F-box and leucine rich repeat protein 5	Homo sapiens	273-278
28768766-10	2017	Conversely, expression of either IRP induced FBXL5 protein level, demonstrating a negative feedback loop limiting excessive accumulation of iron-response element RNA-binding activity, whose disruption reduces cell growth.	Iron	140-144	F-box and leucine rich repeat protein 5	Homo sapiens	45-50
28768766-11	2017	We conclude that a regulatory circuit involving FBXL5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth.	Iron	96-100	F-box and leucine rich repeat protein 5	Homo sapiens	48-53
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	36-40	iron responsive element binding protein 2	Homo sapiens	297-301
28939752-1	2017	The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5.	Iron	16-20	iron responsive element binding protein 2	Homo sapiens	50-54
28939752-1	2017	The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5.	Iron	16-20	F-box and leucine rich repeat protein 5	Homo sapiens	163-168
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	F-box and leucine rich repeat protein 5	Homo sapiens	273-278
28939752-1	2017	The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5.	Iron	81-83	iron responsive element binding protein 2	Homo sapiens	50-54
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	iron responsive element binding protein 2	Homo sapiens	297-301
28939752-1	2017	The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5.	Iron	81-83	F-box and leucine rich repeat protein 5	Homo sapiens	163-168
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	F-box and leucine rich repeat protein 5	Homo sapiens	273-278
28939752-3	2017	A new study reveals that FBXL5 plays a critical role in limiting IRP1 and IRP2 overaccumulation when cytosolic Fe-S cluster assembly is impaired in order to maintain optimal iron levels for cell viability.	Iron	111-115	F-box and leucine rich repeat protein 5	Homo sapiens	25-30
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	iron responsive element binding protein 2	Homo sapiens	297-301
28939752-3	2017	A new study reveals that FBXL5 plays a critical role in limiting IRP1 and IRP2 overaccumulation when cytosolic Fe-S cluster assembly is impaired in order to maintain optimal iron levels for cell viability.	Iron	174-178	F-box and leucine rich repeat protein 5	Homo sapiens	25-30
28768766-4	2017	How CIA and FBXL5 collaborate to maintain cellular iron homeostasis through IRP1 and other pathways is poorly understood.	Iron	51-55	F-box and leucine rich repeat protein 5	Homo sapiens	12-17
28768766-7	2017	Iron supplementation reversed this growth defect and was associated with FBXL5-dependent polyubiquitination of IRP1.	Iron	0-4	F-box and leucine rich repeat protein 5	Homo sapiens	73-78
28837344-0	2017	Role of Macromolecular Crowding on Stability and Iron Release Kinetics of Serum Transferrin.	Iron	49-53	transferrin	Homo sapiens	80-91
28825294-3	2017	Human Pirin, a nonheme iron (Fe) binding protein, has been shown to modulate the binding affinity between p65 homodimeric NF-kappaB and kappaB DNA.	Iron	23-27	pirin	Homo sapiens	6-11
28825294-3	2017	Human Pirin, a nonheme iron (Fe) binding protein, has been shown to modulate the binding affinity between p65 homodimeric NF-kappaB and kappaB DNA.	Iron	29-31	pirin	Homo sapiens	6-11
28921500-3	2017	Accumulated iron from blood transfusions may be deposited in vital organs including the heart, liver and endocrine organs such as the pituitary glands which can affect growth hormone production.	Iron	12-16	growth hormone 1	Homo sapiens	168-182
28739636-2	2017	We previously demonstrated that ERFE messenger RNA expression and serum protein concentration increase in mice subjected to hemorrhage or EPO therapy, that ERFE acts on hepatocytes to suppress hepcidin, and that the resulting decrease in hepcidin augments iron delivery for intensified erythropoiesis.	Iron	256-260	erythroferrone	Mus musculus	156-160
29404495-6	2017	We found that hepatic NNMT expression is inversely correlated with serum ferritin levels and serum transferrin saturation in patients who are obese, suggesting that body iron stores regulate human liver NNMT expression.	Iron	170-174	transferrin	Homo sapiens	99-110
28531655-3	2017	Herein, Fe/Mg/Ni-layered double hydroxide (LDH) has been successfully prepared and its electrochemical behavior for Pb(II) detection is also studied using square wave anodic stripping voltammetry (SWASV).	Iron	8-10	submaxillary gland androgen regulated protein 3B	Homo sapiens	116-122
28760824-0	2017	The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast.	Iron	107-111	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	63-67
28739636-3	2017	We also showed that ERFE contributes to pathological hepcidin suppression and iron overload in mice with nontransfused beta-thalassemia.	Iron	78-82	erythroferrone	Mus musculus	20-24
28684612-4	2017	Three loci (rs1800562 and rs1799945 in the HFE gene and rs855791 in TMPRSS6) that are each associated with serum iron, transferrin saturation, ferritin, and transferrin in a pattern suggestive of an association with systemic iron status are used as instruments.	Iron	113-117	transmembrane serine protease 6	Homo sapiens	68-75
28883478-0	2017	Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.	Iron	14-18	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	84-91
28883478-0	2017	Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.	Iron	33-37	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	84-91
28883478-4	2017	Here, we show that overexpression of subgroup Ib bHLH transcription factor bHLH039 (39Ox) caused constitutive iron acquisition responses, which resulted in enhanced iron contents in leaves and seeds.	Iron	110-114	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	75-82
28883478-4	2017	Here, we show that overexpression of subgroup Ib bHLH transcription factor bHLH039 (39Ox) caused constitutive iron acquisition responses, which resulted in enhanced iron contents in leaves and seeds.	Iron	165-169	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	75-82
28673786-7	2017	Moreover, the results showed a network in which diurnal variations in systemic iron levels were tightly regulated by hepcidin and Tf/TfR via DCYTB and DMT1.	Iron	79-83	transferrin receptor	Sus scrofa	133-136
28700905-9	2017	Moreover, increased ACE activity was observed in the mesenteric resistance arteries of iron-overloaded rats accompanied by an increase in gp91phox, catalase, ERK1/2 and eNOS protein expression.	Iron	87-91	angiotensin I converting enzyme	Rattus norvegicus	20-23
28700905-9	2017	Moreover, increased ACE activity was observed in the mesenteric resistance arteries of iron-overloaded rats accompanied by an increase in gp91phox, catalase, ERK1/2 and eNOS protein expression.	Iron	87-91	catalase	Rattus norvegicus	148-156
28618115-5	2017	Of note, glutaredoxin 2-mediated protection is not linked to its enzymatic activity as oxidoreductase, but to the disassembly of its uniquely coordinated iron-sulfur cluster using glutathione as non-protein ligand.	Iron	154-158	glutaredoxin	Mus musculus	9-21
28612835-8	2017	Moreover, we suggest that MANEAL is an interesting candidate gene that should be considered in the context of neurological disorders with brain iron accumulation and/or indications of an oligosaccharide storage disease.	Iron	144-148	mannosidase endo-alpha like	Homo sapiens	26-32
28828587-6	2017	Furthermore, inhibition of AMPK or p38 reduced the ability of tryptanthrin to prevent AA + iron-induced cell death and mitochondrial dysfunction.	Iron	91-95	mitogen-activated protein kinase 14	Homo sapiens	35-38
28824243-1	2017	Objective of the study was to assess effect of iron therapy on serum hepcidin levels in iron deficient pregnant women and its correlation with hemoglobin, serum iron profile and C-reactive protein (CRP).	Iron	47-51	C-reactive protein	Homo sapiens	178-196
28824243-1	2017	Objective of the study was to assess effect of iron therapy on serum hepcidin levels in iron deficient pregnant women and its correlation with hemoglobin, serum iron profile and C-reactive protein (CRP).	Iron	47-51	C-reactive protein	Homo sapiens	198-201
28983190-2	2017	Recent evidence, however, has linked this protein to iron incorporation, loaded through transient interactions with the poly r(C)-binding protein 1, a metallo-chaperone and storage protein.	Iron	53-57	poly(rC) binding protein 1	Homo sapiens	120-147
28983190-5	2017	Furthermore, our data strongly support that complexes between histone deacetylase 8 and poly r(C)-binding protein 1 are specific, and that they are equally strong when both zinc and iron-loaded proteins are involved, or perhaps mildly promoted in the latter case, suggesting an in vivo role for the non-canonical, iron-incorporated histone deacetylase.	Iron	182-186	poly(rC) binding protein 1	Homo sapiens	88-115
28983190-5	2017	Furthermore, our data strongly support that complexes between histone deacetylase 8 and poly r(C)-binding protein 1 are specific, and that they are equally strong when both zinc and iron-loaded proteins are involved, or perhaps mildly promoted in the latter case, suggesting an in vivo role for the non-canonical, iron-incorporated histone deacetylase.	Iron	314-318	poly(rC) binding protein 1	Homo sapiens	88-115
28930842-4	2017	PATIENT CONCERNS: We report the case of a 48-year-old Chinese Han woman who presented with abnormal liver function, diabetes mellitus, hyperferritinemia, and high transferrin saturation, with severe iron overload in parenchymal cells, Kupffer cells, and periportal fibrosis on liver biopsy.	Iron	199-203	transferrin	Homo sapiens	163-174
27632558-0	2017	Probing the conformational changes and peroxidase-like activity of cytochrome c upon interaction with iron nanoparticles.	Iron	102-106	cytochrome c, somatic	Homo sapiens	67-79
27632558-1	2017	Herein, the interaction of iron nanoparticle (Fe-NP) with cytochrome c (Cyt c) was investigated, and a range of techniques such as dynamic light scattering (DLS), zeta potential measurements, static and synchronous fluorescence spectroscopy, near and far circular dichroism (CD) spectroscopy, and ultraviolet-visible (UV-vis) spectroscopy were used to analyze the interaction between Cyt c and Fe-NP.	Iron	27-31	cytochrome c, somatic	Homo sapiens	58-70
27632558-1	2017	Herein, the interaction of iron nanoparticle (Fe-NP) with cytochrome c (Cyt c) was investigated, and a range of techniques such as dynamic light scattering (DLS), zeta potential measurements, static and synchronous fluorescence spectroscopy, near and far circular dichroism (CD) spectroscopy, and ultraviolet-visible (UV-vis) spectroscopy were used to analyze the interaction between Cyt c and Fe-NP.	Iron	27-31	cytochrome c, somatic	Homo sapiens	72-77
28970716-7	2017	Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis.	Iron	54-58	transferrin	Homo sapiens	18-29
28712636-11	2017	Iron-sequestering proteins including transferrin and lactoferrin/lactotransferrin were found in many samples.	Iron	0-4	transferrin	Homo sapiens	37-48
28712636-11	2017	Iron-sequestering proteins including transferrin and lactoferrin/lactotransferrin were found in many samples.	Iron	0-4	lactotransferrin	Homo sapiens	65-81
28967645-7	2017	In cells with CSC characteristics an increased expression of transferrin and its receptor, ferritin, fentorin and hepcidin was revealed indicating activation of the endogenous iron metabolism.	Iron	176-180	transferrin	Homo sapiens	61-72
28075024-9	2017	Genes related to heme degradation and iron transport such as hepcidin, transferrin and haptoglobin were primary upregulated in Atlantic salmon; meanwhile, in coho salmon, genes associated with heme biosynthesis were strongly transcribed.	Iron	38-42	serotransferrin-1	Salmo salar	71-82
28915963-0	2017	Hepcidin and metallothioneins as molecular base for sex-dependent differences in clinical course of experimental autoimmune encephalomyelitis in chronic iron overload.	Iron	153-157	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
28915963-7	2017	We hypothesize that those differences arise on molecular level in different expression of stress response proteins hepcidin and metallothioneins in male and female iron overloaded rats.	Iron	164-168	hepcidin antimicrobial peptide	Rattus norvegicus	115-123
28915963-9	2017	Hepcidin is additionally upregulated by estrogen in female rats and therefore causes higher degradation of iron exporter ferroportin and sequestration of iron in the cells, lowering the possibility for the development of oxidative stress.	Iron	107-111	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
28915963-9	2017	Hepcidin is additionally upregulated by estrogen in female rats and therefore causes higher degradation of iron exporter ferroportin and sequestration of iron in the cells, lowering the possibility for the development of oxidative stress.	Iron	154-158	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
28248443-0	2017	Iron overload induces apoptosis of murine preosteoblast cells via ROS and inhibition of AKT pathway.	Iron	0-4	thymoma viral proto-oncogene 1	Mus musculus	88-91
28571715-2	2017	In AD, iron promotes amyloid beta (Abeta) neurotoxicity by producing free radical damage and OS in brain areas affected by neurodegeneration, presumably by facilitating the aggregation of Abeta.	Iron	7-11	amyloid beta precursor protein	Homo sapiens	21-33
28571715-2	2017	In AD, iron promotes amyloid beta (Abeta) neurotoxicity by producing free radical damage and OS in brain areas affected by neurodegeneration, presumably by facilitating the aggregation of Abeta.	Iron	7-11	amyloid beta precursor protein	Homo sapiens	35-40
28571715-2	2017	In AD, iron promotes amyloid beta (Abeta) neurotoxicity by producing free radical damage and OS in brain areas affected by neurodegeneration, presumably by facilitating the aggregation of Abeta.	Iron	7-11	amyloid beta precursor protein	Homo sapiens	188-193
28248443-11	2017	CONCLUSION: Iron overload can generate ROS in cells, inhibit AKT kinase and its downstream proteins activity, and subsequently initiate apoptotic events.	Iron	12-16	thymoma viral proto-oncogene 1	Mus musculus	61-64
28863176-1	2017	Mutations in PANK2 lead to neurodegeneration with brain iron accumulation.	Iron	56-60	pantothenate kinase 2	Homo sapiens	13-18
28399115-3	2017	The mammalian target of rapamycin (mTOR) pathway senses the status of critical metabolites (e.g., oxygen, iron), thereby regulating hippocampal growth and function.	Iron	106-110	mechanistic target of rapamycin kinase	Homo sapiens	4-33
28399115-3	2017	The mammalian target of rapamycin (mTOR) pathway senses the status of critical metabolites (e.g., oxygen, iron), thereby regulating hippocampal growth and function.	Iron	106-110	mechanistic target of rapamycin kinase	Homo sapiens	35-39
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	microRNA 141	Homo sapiens	104-111
28532595-2	2017	This study aims to ascertain the optimal, tolerance and toxic levels of iron in a protein-free embryo culture medium (PFM) to determine the effect of iron on embryonic development.	Iron	72-76	msh homeobox 2	Homo sapiens	118-121
28414307-4	2017	We demonstrated that HDAC5 inhibition induces an iron-dependent reactive oxygen species (ROS) production, ultimately leading to apoptotic cell death as well as mechanisms of mitochondria quality control (mitophagy and mitobiogenesis).	Iron	49-53	histone deacetylase 5	Homo sapiens	21-26
28714505-10	2017	Our data clearly showed that catalase inhibition of DpdtC was not due to direct chelation of iron from heme (killing), but through an allosteric effect.	Iron	93-97	catalase	Homo sapiens	29-37
28855507-6	2017	By contrast, banded iron formations formed when Fe-concentrations were much higher (&gt; 50 muM).	Iron	20-24	latexin	Homo sapiens	92-95
28855507-6	2017	By contrast, banded iron formations formed when Fe-concentrations were much higher (&gt; 50 muM).	Iron	48-50	latexin	Homo sapiens	92-95
28811531-5	2017	We found that Mtk specifically targets the iron-sulfur subunit (SdhB) of succinate-coenzyme Q reductase (SQR).	Iron	43-47	Metchnikowin	Drosophila melanogaster	14-17
28878728-1	2017	Here, we report the case of a 36-year-old patient with a diagnosis of de novo mutation of the WDR45 gene, responsible for beta-propeller protein-associated neurodegeneration, a phenotypically distinct, X-linked dominant form of Neurodegeneration with Brain Iron Accumulation.	Iron	257-261	WD repeat domain 45	Homo sapiens	94-99
28827805-8	2017	In contrast, the expression of transferrin, which is responsible for the transport of iron into cells, is increased following treatment with lapatinib alone or in combination with siramesine.	Iron	86-90	transferrin	Homo sapiens	31-42
28615452-0	2017	Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.	Iron	17-21	epidermal growth factor receptor	Homo sapiens	65-97
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	poly(rC) binding protein 2	Homo sapiens	50-76
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	poly(rC) binding protein 2	Homo sapiens	78-83
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	poly(rC) binding protein 2	Homo sapiens	50-76
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	poly(rC) binding protein 2	Homo sapiens	78-83
28655775-9	2017	Furthermore, in vitro reconstitution experiments with purified recombinant proteins indicated that HO1 could bind to PCBP2 in the presence of heme, whereas loading of PCBP2 with ferrous iron caused PCBP2 to lose its affinity for HO1.	Iron	178-190	poly(rC) binding protein 2	Homo sapiens	167-172
28655775-9	2017	Furthermore, in vitro reconstitution experiments with purified recombinant proteins indicated that HO1 could bind to PCBP2 in the presence of heme, whereas loading of PCBP2 with ferrous iron caused PCBP2 to lose its affinity for HO1.	Iron	178-190	poly(rC) binding protein 2	Homo sapiens	167-172
28655775-10	2017	These results indicate that ferrous iron released from heme can be bound by PCBP2 and suggest a model for an integrated heme catabolism and iron transport metabolon.	Iron	36-40	poly(rC) binding protein 2	Homo sapiens	76-81
28655775-10	2017	These results indicate that ferrous iron released from heme can be bound by PCBP2 and suggest a model for an integrated heme catabolism and iron transport metabolon.	Iron	140-144	poly(rC) binding protein 2	Homo sapiens	76-81
29050310-9	2017	In PC12 cells, the miR-27b inhibitor diminished iron-induced oxidative stress, inflammation and apoptosis, and those effects were blocked by Nrf2 knockdown.	Iron	48-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	141-145
28655775-0	2017	The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer.	Iron	4-8	poly(rC) binding protein 2	Homo sapiens	19-45
28655775-1	2017	Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.	Iron	51-55	cytochrome p450 oxidoreductase	Homo sapiens	116-147
28655775-1	2017	Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.	Iron	208-212	cytochrome p450 oxidoreductase	Homo sapiens	116-147
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	35-39	poly(rC) binding protein 2	Homo sapiens	50-76
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	35-39	poly(rC) binding protein 2	Homo sapiens	78-83
28615452-0	2017	Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.	Iron	17-21	epidermal growth factor receptor	Homo sapiens	99-103
28615455-4	2017	Additionally, an iron-regulated metastasis suppressor interacts with the epidermal growth factor receptor and mediates its downstream signaling activity.	Iron	17-21	epidermal growth factor receptor	Homo sapiens	73-105
28737805-0	2017	Nonhelical heterometallic [Mo2M(npo)4(NCS)2] string complexes (M = Fe, Co, Ni) with high single-molecule conductance.	Iron	67-69	cytosolic thiouridylase subunit 2	Homo sapiens	38-43
28671819-2	2017	Unlike the evolutionarily related proteins hemoglobin and myoglobin, cytoglobin shows a six-coordinated heme binding, with the heme iron coordinated by two histidine side chains.	Iron	132-136	cytoglobin	Homo sapiens	69-79
28585071-3	2017	We hypothesize that non-transferrin-bound iron (NBTI) is possibly a better marker to predict the effect of IO on the outcome than serum ferritin (SF), which however is not specific for IO.	Iron	42-46	transferrin	Homo sapiens	24-35
28639108-7	2017	Fe-treatment decreased PPAR-gamma expression and increased Col-1 expression.	Iron	0-2	peroxisome proliferator activated receptor gamma	Homo sapiens	23-33
28829493-0	2017	Effects of IL-10 on iron metabolism in LPS-induced inflammatory mice via modulating hepcidin expression.	Iron	20-24	interleukin 10	Mus musculus	11-16
28899019-1	2017	See Derry and Kent (doi:10.1093/awx167) for a scientific commentary on this article.The large variance in cognitive deterioration in subjects who test positive for amyloid-beta by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with amyloid-beta to accelerate Alzheimer"s disease progression.	Iron	256-260	amyloid beta precursor protein	Homo sapiens	164-176
28829493-11	2017	IL-10 treatment group significantly facilitated RBC, Hb, HCT, MCV and Hb iron contents in LPS-induced inflammatory model mice, which also had lower hepcidin, IL-6, TNF-alpha, TfR2 or STAT3 expression (p &lt; 0.05 compared to LPS group).	Iron	73-77	interleukin 10	Mus musculus	0-5
28829493-12	2017	CONCLUSIONS: IL-10 can improve iron metabolism and alleviate anemia via suppressing inflammatory factor, modulating STAT3 signal pathway, down-regulating hepcidin expression and inhibiting TfR expression.	Iron	31-35	interleukin 10	Mus musculus	13-18
28609757-1	2017	Human Transferrin (hTf) is a metal-binding protein found in blood plasma and is well known for its role in iron delivery.	Iron	107-111	transferrin	Homo sapiens	6-17
28536109-0	2017	Effect of iron on cholesterol 7alpha-hydroxylase expression in alcohol-induced hepatic steatosis in mice.	Iron	10-14	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	18-48
28536109-5	2017	Cyp7a1 expression can be regulated by in vivo and in vitro iron treatment.	Iron	59-63	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	0-6
28536109-7	2017	The results indicate that hepatic iron overloading in AFLD mice decreased Cyp7a1 expression and resulted in cholesterol accumulation, providing a new mechanism of iron-regulated gene transcription and translation through the interaction between iron and a noncanonical IRE structure in Cyp7a1 mRNA.	Iron	34-38	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	74-80
28536109-7	2017	The results indicate that hepatic iron overloading in AFLD mice decreased Cyp7a1 expression and resulted in cholesterol accumulation, providing a new mechanism of iron-regulated gene transcription and translation through the interaction between iron and a noncanonical IRE structure in Cyp7a1 mRNA.	Iron	34-38	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	286-292
28536109-7	2017	The results indicate that hepatic iron overloading in AFLD mice decreased Cyp7a1 expression and resulted in cholesterol accumulation, providing a new mechanism of iron-regulated gene transcription and translation through the interaction between iron and a noncanonical IRE structure in Cyp7a1 mRNA.	Iron	163-167	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	74-80
28536109-7	2017	The results indicate that hepatic iron overloading in AFLD mice decreased Cyp7a1 expression and resulted in cholesterol accumulation, providing a new mechanism of iron-regulated gene transcription and translation through the interaction between iron and a noncanonical IRE structure in Cyp7a1 mRNA.	Iron	163-167	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	286-292
28536109-7	2017	The results indicate that hepatic iron overloading in AFLD mice decreased Cyp7a1 expression and resulted in cholesterol accumulation, providing a new mechanism of iron-regulated gene transcription and translation through the interaction between iron and a noncanonical IRE structure in Cyp7a1 mRNA.	Iron	163-167	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	74-80
28536109-7	2017	The results indicate that hepatic iron overloading in AFLD mice decreased Cyp7a1 expression and resulted in cholesterol accumulation, providing a new mechanism of iron-regulated gene transcription and translation through the interaction between iron and a noncanonical IRE structure in Cyp7a1 mRNA.	Iron	163-167	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	286-292
28405919-0	2017	Iron overload may promote alteration of NK cells and hematopoietic stem/progenitor cells by JNK and P38 pathway in myelodysplastic syndromes.	Iron	0-4	mitogen-activated protein kinase 8	Homo sapiens	92-95
28405919-0	2017	Iron overload may promote alteration of NK cells and hematopoietic stem/progenitor cells by JNK and P38 pathway in myelodysplastic syndromes.	Iron	0-4	mitogen-activated protein kinase 14	Homo sapiens	100-103
28405919-9	2017	MDS patients with iron overload had higher JNK expression and lower p38 expression in NK cells, and higher p38 expression in HSPCs compared with non-iron overload group.	Iron	18-22	mitogen-activated protein kinase 8	Homo sapiens	43-46
28405919-9	2017	MDS patients with iron overload had higher JNK expression and lower p38 expression in NK cells, and higher p38 expression in HSPCs compared with non-iron overload group.	Iron	18-22	mitogen-activated protein kinase 14	Homo sapiens	68-71
28405919-9	2017	MDS patients with iron overload had higher JNK expression and lower p38 expression in NK cells, and higher p38 expression in HSPCs compared with non-iron overload group.	Iron	18-22	mitogen-activated protein kinase 14	Homo sapiens	107-110
28341391-7	2017	Increased injury in KO +Fe was associated with activated protein kinase B (AKT), ERK, and NF-kappaB, along with reappearance of beta-catenin and target gene Cyp2e1, which promoted lipid peroxidation and hepatic damage.	Iron	24-26	thymoma viral proto-oncogene 1	Mus musculus	75-78
28341391-7	2017	Increased injury in KO +Fe was associated with activated protein kinase B (AKT), ERK, and NF-kappaB, along with reappearance of beta-catenin and target gene Cyp2e1, which promoted lipid peroxidation and hepatic damage.	Iron	24-26	mitogen-activated protein kinase 1	Mus musculus	81-84
28341391-7	2017	Increased injury in KO +Fe was associated with activated protein kinase B (AKT), ERK, and NF-kappaB, along with reappearance of beta-catenin and target gene Cyp2e1, which promoted lipid peroxidation and hepatic damage.	Iron	24-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
28476637-2	2017	In this study, concomitant with the accumulation of iron and oligomeric alpha-synuclein, higher expression of a lysosomal iron transporter, natural resistance-associated macrophage protein-1 (Nramp1), was observed in microglia in post-mortem striatum of sporadic PD patients.	Iron	52-56	solute carrier family 11 member 1	Homo sapiens	140-190
28476637-2	2017	In this study, concomitant with the accumulation of iron and oligomeric alpha-synuclein, higher expression of a lysosomal iron transporter, natural resistance-associated macrophage protein-1 (Nramp1), was observed in microglia in post-mortem striatum of sporadic PD patients.	Iron	122-126	solute carrier family 11 member 1	Homo sapiens	140-190
28476637-2	2017	In this study, concomitant with the accumulation of iron and oligomeric alpha-synuclein, higher expression of a lysosomal iron transporter, natural resistance-associated macrophage protein-1 (Nramp1), was observed in microglia in post-mortem striatum of sporadic PD patients.	Iron	122-126	solute carrier family 11 member 1	Homo sapiens	192-198
28476637-3	2017	Using Nramp1-deficient macrophage (RAW264.7) and microglial (BV-2) cells as in-vitro models, iron exposure significantly reduced the degradation rate of the administered human alpha-synuclein oligomers, which can be restored by the expression of the wild-type, but not mutant (D543N), Nramp1.	Iron	93-97	solute carrier family 11 member 1	Homo sapiens	285-291
29212168-0	2017	Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells.	Iron	54-58	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
29296776-5	2017	Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase.	Iron	207-211	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	21-34
29296776-5	2017	Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase.	Iron	207-211	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	21-34
29296776-3	2017	The process of iron uptake into duodenal enterocytes is relatively well understood, but less is known about the functional coupling between the iron exporter ferroportin 1 and the basolateral membrane iron oxidase hephaestin (Heph).	Iron	144-148	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	158-171
29296776-5	2017	Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase.	Iron	44-48	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	21-34
29212168-2	2017	Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites.	Iron	50-54	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
28727840-3	2017	In this study, we tested Fes inhibitors from three different chemical classes for their growth-suppressive activity against Flt3-ITD+ myeloid leukemia cell lines (MV4-11, MOLM-13 and MOLM-14) vs. myeloid cells with wild-type Flt3 (THP-1).	Iron	25-28	fms related receptor tyrosine kinase 3	Homo sapiens	124-128
28769992-13	2017	With tannin consumption, PRP production is increased, and may be an initial line of defense against tannin-non-heme iron chelation in vivo.	Iron	116-120	prion protein	Homo sapiens	25-28
28319068-7	2017	Mechanistic studies demonstrate that iron increases metastatic spread by facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6).	Iron	37-41	interleukin 6	Homo sapiens	158-171
28319068-7	2017	Mechanistic studies demonstrate that iron increases metastatic spread by facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6).	Iron	37-41	interleukin 6	Homo sapiens	173-177
28727840-3	2017	In this study, we tested Fes inhibitors from three different chemical classes for their growth-suppressive activity against Flt3-ITD+ myeloid leukemia cell lines (MV4-11, MOLM-13 and MOLM-14) vs. myeloid cells with wild-type Flt3 (THP-1).	Iron	25-28	fms related receptor tyrosine kinase 3	Homo sapiens	225-229
28727840-3	2017	In this study, we tested Fes inhibitors from three different chemical classes for their growth-suppressive activity against Flt3-ITD+ myeloid leukemia cell lines (MV4-11, MOLM-13 and MOLM-14) vs. myeloid cells with wild-type Flt3 (THP-1).	Iron	25-28	GLI family zinc finger 2	Homo sapiens	231-236
29348830-3	2017	As a kind of iron flavin dependent enzyme, dihydroorotate dehydrogenase (DHODH, EC 1.3.3.1) is the fourth and a key enzyme in the de novo biosynthesis of pyrimidines.	Iron	13-17	dihydroorotate dehydrogenase (quinone)	Homo sapiens	43-71
28769786-5	2017	We recently described that 18-month-old NF-kappaB/c-Rel deficient mice (c-rel-/-) develop a spontaneous late-onset PD-like phenotype encompassing L-DOPA-responsive motor impairment, nigrostriatal neuron degeneration, alpha-synuclein and iron accumulation.	Iron	237-241	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
29348830-3	2017	As a kind of iron flavin dependent enzyme, dihydroorotate dehydrogenase (DHODH, EC 1.3.3.1) is the fourth and a key enzyme in the de novo biosynthesis of pyrimidines.	Iron	13-17	dihydroorotate dehydrogenase (quinone)	Homo sapiens	73-78
28720726-4	2017	Iron metabolism and, more particularly, Fe-S cluster formation are involved in regulating this process, since the responsible Hsp70 chaperone, Ssq1, is required.	Iron	0-4	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	143-147
28720726-4	2017	Iron metabolism and, more particularly, Fe-S cluster formation are involved in regulating this process, since the responsible Hsp70 chaperone, Ssq1, is required.	Iron	40-44	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	143-147
28389358-5	2017	Furthermore, Fes was found to be involved in monocytic differentiation via upregulation of PU.1 and MCSFR and Fes siRNA could also inhibit 1,25D3-induced monocytic differentiation of U937 and HL60 cells and decrease mRNA expression of CD11c, CD18 and CD64.	Iron	13-16	integrin subunit beta 2	Homo sapiens	242-246
28644630-1	2017	The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells.	Iron	172-176	transferrin	Homo sapiens	61-72
28644630-2	2017	This finding enriches our bioinspired drug design strategy for Ti(IV)-based anticancer therapeutics, which applies a family of Fe(III) chelators termed chemical transferrin mimetic (cTfm) ligands to inhibit Fe bioavailability in cancer cells.	Iron	127-129	transferrin	Homo sapiens	161-172
28790810-6	2017	In the total population, Pearson correlation coefficients between 1) serum ferritin and iron concentrations and transferrin saturation and 2) FVC and FEV1 were significantly positive; whereas those between 1) serum ferritin concentrations and transferrin saturation and 2) FEV1/FVC were significantly negative.	Iron	88-92	transferrin	Homo sapiens	112-123
29137259-3	2017	Here we report that prostate cancer cells overexpress IRP2 and that overexpression of IRP2 drives the altered iron phenotype of prostate cancer cells.	Iron	110-114	iron responsive element binding protein 2	Homo sapiens	86-90
29137259-4	2017	IRP2 knockdown in prostate cancer cell lines reduces intracellular iron and causes cell cycle inhibition and apoptosis.	Iron	67-71	iron responsive element binding protein 2	Homo sapiens	0-4
29137259-8	2017	These results demonstrate that upregulation of IRP2 in prostate cancer cells co-opts normal iron regulatory mechanisms to facilitate iron retention and drive enhanced tumor growth.	Iron	92-96	iron responsive element binding protein 2	Homo sapiens	47-51
29137259-8	2017	These results demonstrate that upregulation of IRP2 in prostate cancer cells co-opts normal iron regulatory mechanisms to facilitate iron retention and drive enhanced tumor growth.	Iron	133-137	iron responsive element binding protein 2	Homo sapiens	47-51
28431372-5	2017	With the highest iron concentration (400 mg L-1) applied, the DFSBR achieved 95% of iron removal efficiency.	Iron	17-21	immunoglobulin kappa variable 1-16	Homo sapiens	44-47
28431372-5	2017	With the highest iron concentration (400 mg L-1) applied, the DFSBR achieved 95% of iron removal efficiency.	Iron	84-88	immunoglobulin kappa variable 1-16	Homo sapiens	44-47
28515324-4	2017	Recent studies show that RNR cofactor biosynthesis shares the same source of iron, in the form of [2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for maturation of [4Fe-4S] clusters in cytosolic and nuclear proteins.	Iron	77-81	electron carrier DRE2	Saccharomyces cerevisiae S288C	201-205
28399452-5	2017	Additionally, we verified by using copper and iron ion chelators that the two metal ion-mediated oxidations of compound 3 to its corresponding electrophilic o-quinone, contribute significantly to its Nrf2-dependent cytoprotection.	Iron	46-50	NFE2 like bZIP transcription factor 2	Homo sapiens	200-204
28703745-2	2017	Previous studies have shown that this protein can protect mitochondria from iron-induced oxidative damage, while FtMt overexpression in cultured cells decreases cytosolic iron availability and protects against oxidative damage.	Iron	171-175	ferritin mitochondrial	Mus musculus	113-117
28065861-2	2017	Hemin, an iron-containing porphyrin, activates heme oxygenase-1 (HO-1), an enzyme with anti-inflammatory and cytoprotective properties.	Iron	10-14	heme oxygenase 1	Mus musculus	47-63
28515324-9	2017	Thus, the pathways for RNR and Fe-S cluster biogenesis bifurcate after the Dre2-Tah18 step.	Iron	31-35	electron carrier DRE2	Saccharomyces cerevisiae S288C	75-79
28515324-10	2017	We conclude that RNR cofactor biogenesis requires the ISC machinery to mature the Grx3/4 and Dre2 Fe-S proteins, which then function in iron and electron delivery to RNR, respectively.	Iron	136-140	electron carrier DRE2	Saccharomyces cerevisiae S288C	93-97
28634302-0	2017	Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.	Iron	19-23	LYR motif containing 4	Homo sapiens	110-115
28680084-1	2017	Pantothenate kinase-associated neurodegeneration is a rare hereditary neurodegenerative disorder associated with nucleotide variation(s) in mitochondrial human Pantothenate kinase 2 (hPanK2) protein encoding PANK2 gene, and is characterized by symptoms of extra-pyramidal dysfunction and accumulation of non-heme iron predominantly in the basal ganglia of the brain.	Iron	313-317	pantothenate kinase 2	Homo sapiens	160-181
28680084-1	2017	Pantothenate kinase-associated neurodegeneration is a rare hereditary neurodegenerative disorder associated with nucleotide variation(s) in mitochondrial human Pantothenate kinase 2 (hPanK2) protein encoding PANK2 gene, and is characterized by symptoms of extra-pyramidal dysfunction and accumulation of non-heme iron predominantly in the basal ganglia of the brain.	Iron	313-317	pantothenate kinase 2	Homo sapiens	183-189
28680084-1	2017	Pantothenate kinase-associated neurodegeneration is a rare hereditary neurodegenerative disorder associated with nucleotide variation(s) in mitochondrial human Pantothenate kinase 2 (hPanK2) protein encoding PANK2 gene, and is characterized by symptoms of extra-pyramidal dysfunction and accumulation of non-heme iron predominantly in the basal ganglia of the brain.	Iron	313-317	pantothenate kinase 2	Homo sapiens	208-213
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	182-186	LYR motif containing 4	Homo sapiens	10-15
28672025-0	2017	Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines.	Iron	24-28	interleukin 6	Mus musculus	0-13
28672025-5	2017	In the present study, we aimed to determine how iron levels affect interleukin-6 (IL-6) synthesis, and the effect of IL-6 on cellular iron metabolism in BV2 microglial cells.IL-6 mRNA was up-regulated after FAC treatment for 12 h in BV2 cells.	Iron	48-52	interleukin 6	Mus musculus	67-80
28672025-5	2017	In the present study, we aimed to determine how iron levels affect interleukin-6 (IL-6) synthesis, and the effect of IL-6 on cellular iron metabolism in BV2 microglial cells.IL-6 mRNA was up-regulated after FAC treatment for 12 h in BV2 cells.	Iron	48-52	interleukin 6	Mus musculus	82-86
28672025-5	2017	In the present study, we aimed to determine how iron levels affect interleukin-6 (IL-6) synthesis, and the effect of IL-6 on cellular iron metabolism in BV2 microglial cells.IL-6 mRNA was up-regulated after FAC treatment for 12 h in BV2 cells.	Iron	134-138	interleukin 6	Mus musculus	117-121
28672025-5	2017	In the present study, we aimed to determine how iron levels affect interleukin-6 (IL-6) synthesis, and the effect of IL-6 on cellular iron metabolism in BV2 microglial cells.IL-6 mRNA was up-regulated after FAC treatment for 12 h in BV2 cells.	Iron	134-138	interleukin 6	Mus musculus	117-121
28672025-6	2017	Iron regulatory protein 1 (IRP1) and divalent metal transporter 1 (DMT1) were up-regulated and iron exporter ferroportin 1 (FPN1) was down-regulated in BV2 cells after 24 h of IL-6 treatment.	Iron	95-99	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	109-122
28672025-6	2017	Iron regulatory protein 1 (IRP1) and divalent metal transporter 1 (DMT1) were up-regulated and iron exporter ferroportin 1 (FPN1) was down-regulated in BV2 cells after 24 h of IL-6 treatment.	Iron	95-99	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	124-128
28672025-8	2017	These results suggest that iron load could increase IL-6 mRNA expression in BV2 cells.	Iron	27-31	interleukin 6	Mus musculus	52-56
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	69-73	LYR motif containing 4	Homo sapiens	10-15
28421266-6	2017	The results showed that iron overload could reduce the percentage of CD3+ T cells and the ratio of Th1/Th2 and Tc1/Tc2 but increase the percentage of regulatory T (Treg) cells and the ratio of CD4/CD8.	Iron	24-28	negative elongation factor complex member C/D, Th1l	Mus musculus	99-102
28681287-3	2017	The present study deals with the stability and fate of synthesized zero-valent iron nanoparticles in the upper and lower layers of freshwater microcosm system at a concentration of 1000 mg L-1.	Iron	79-83	immunoglobulin kappa variable 1-16	Homo sapiens	189-192
28430694-0	2017	Iron Loading Exaggerates the Inflammatory Response to the Toll-like Receptor 4 Ligand Lipopolysaccharide by Altering Mitochondrial Homeostasis.	Iron	0-4	toll-like receptor 4	Mus musculus	58-78
28511798-5	2017	Furthermore, the significantly increased Cu and Fe contents and the markedly up-regulated CTR1 and ATP7A expression in acute cold-stimulated BAT indicates the involvement of both Cu and Fe in the BAT-mediated thermogenesis.	Iron	186-188	solute carrier family 31, member 1	Mus musculus	90-94
28511798-5	2017	Furthermore, the significantly increased Cu and Fe contents and the markedly up-regulated CTR1 and ATP7A expression in acute cold-stimulated BAT indicates the involvement of both Cu and Fe in the BAT-mediated thermogenesis.	Iron	186-188	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	99-104
28216263-2	2017	Absolute ID/IDA, i.e. the decrease of total body iron, is easily diagnosed based on decreased levels of serum ferritin and transferrin saturation.	Iron	49-53	transferrin	Homo sapiens	123-134
28389405-3	2017	In this study we investigated the regulation of four representative Nrf2-regulated antioxidant genes; i.e., glutamate cysteine ligase (GCL) catalytic subunit (GCLC), GCL modifier subunit (GCLM), heme oxygenase 1 (HO-1), and NAD(P)H:quinone oxidoreductase-1 (NQO-1), by iron-coated silica nanoparticles (SiO2-Fe) in human THP-1 macrophages.	Iron	269-273	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
28615259-4	2017	Depending on the approach used to adjust for inflammation (CRP plus AGP), the estimated prevalence of depleted iron stores increased by 7-25 and 2-8 absolute median percentage points for PSC and WRA, respectively, compared with unadjusted values.	Iron	111-115	C-reactive protein	Homo sapiens	59-62
28254021-0	2017	Trypsin purification using magnetic particles of azocasein-iron composite.	Iron	59-63	serine protease 1	Oreochromis niloticus	0-7
28389405-3	2017	In this study we investigated the regulation of four representative Nrf2-regulated antioxidant genes; i.e., glutamate cysteine ligase (GCL) catalytic subunit (GCLC), GCL modifier subunit (GCLM), heme oxygenase 1 (HO-1), and NAD(P)H:quinone oxidoreductase-1 (NQO-1), by iron-coated silica nanoparticles (SiO2-Fe) in human THP-1 macrophages.	Iron	308-310	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
28060459-10	2017	CONCLUSIONS: These results suggest that elevated iron storage is associated with increased risk of type 2 diabetes in normal weight individuals, and that this association is partly mediated through liver dysfunction and resulting insulin resistance.	Iron	49-53	insulin	Homo sapiens	230-237
28246923-3	2017	The peroxidase activity of cyt c increases by Met80 dissociation from the heme iron, which may trigger apoptosis.	Iron	79-83	cytochrome c, somatic	Homo sapiens	27-32
28246923-6	2017	According to differential scanning calorimetric measurements, Met80 coordination to the heme iron had an effect on the stabilization of the monomer (DeltaH = 16 kcal/mol), whereas no large difference was observed between the dimer-to-monomer dissociation temperatures of WT and M80A cyt c (61.0  C).	Iron	93-97	cytochrome c, somatic	Homo sapiens	283-288
28246923-7	2017	The activation enthalpy values were similar and relatively large for the dissociation of both WT and M80A cyt c dimers (WT, 120 +- 10 kcal/mol; M80A, 110 +- 10 kcal/mol), indicating that the dimers suffered large structural changes upon dissociation to monomers independent of the Met80 coordination to the heme iron.	Iron	312-316	cytochrome c, somatic	Homo sapiens	106-111
28460338-0	2017	Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-68
28460338-4	2017	Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells.	Iron	100-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-68
28932395-5	2017	We identified a c.700 C&gt;T (p.Arg 234*) mutation in exon 9 of the WDR45 gene, which had not been reported in Japanese patients with beta-propeller protein-associated neurodegeneration (a neurodegeneration with brain iron accumulation subtype).	Iron	218-222	WD repeat domain 45	Homo sapiens	68-73
28460338-2	2017	In this study, we aim to explore the effect of HIF-1a/ROS on erythroid apoptosis in MDS patients with iron overload.	Iron	102-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-53
28460338-4	2017	Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells.	Iron	178-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-60
28460338-4	2017	Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells.	Iron	178-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-68
28460338-4	2017	Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells.	Iron	100-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-60
28460338-5	2017	And gene knockdown of HIF-1a got the similar results as iron overload in MDS/AML cells.	Iron	56-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-28
28460338-7	2017	Importantly, the HIF-1a protein levels of erythrocytes elevated obviously after incubation with desferrioxamine (DFO) from MDS patients with iron overload, accompanied by ROS levels inhibited and erythroid apoptosis reduced.	Iron	141-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-23
28460338-8	2017	Taken together, our findings determine that the HIF-1a/ROS signaling pathway plays a key role in promoting erythroid apoptosis in MDS patients with iron overload.	Iron	148-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-54
28671021-0	2017	Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool.	Iron	102-106	transferrin	Homo sapiens	16-27
28521058-3	2017	In a recent proteomic study (Kong et al., 2016), several components of this system were up-regulated in high feed efficiency (FE) compared to low FE breast muscle; notably adenine nucleotide translocase (ANT), voltage dependent activated channel (VDAC), the brain isoform of creatine kinase (CK-B), and several proteins of the electron transport chain.	Iron	126-128	creatine kinase B	Homo sapiens	292-296
28386789-4	2017	Until the results of such studies are available, it appears reasonable to propose IV iron therapy to anemic cancer patients as the resulting rise of Hb level may increase their quality of life and performance status and reduce the need for erythropoietin-stimulating agents and/or blood transfusions.	Iron	85-89	erythropoietin	Homo sapiens	240-254
28671021-12	2017	The expressions of iron regulatory proteins in human cholangiocarcinoma tissues and normal liver from cadaveric donors revealed that transferrin receptor-1 expression was increased in the cancer cells of cholangiocarcinoma tissues when compared with the adjacent normal bile ducts and was significantly correlated with cholangiocarcinoma metastasis.	Iron	19-23	transferrin	Homo sapiens	133-144
28671021-14	2017	Additionally, the suppression of transferrin receptor-1 expression significantly decreased intracellular labile iron pool, cholangiocarcinoma migration, and cell proliferation when compared with control media and control small interfering RNA.	Iron	112-116	transferrin	Homo sapiens	33-44
28671021-15	2017	In Conclusion, high expression of transferrin receptor-1 resulting in iron uptake contributes to increase in the labile iron pool which plays roles in cholangiocarcinoma progression with aggressive clinical outcomes.	Iron	70-74	transferrin	Homo sapiens	34-45
28671021-15	2017	In Conclusion, high expression of transferrin receptor-1 resulting in iron uptake contributes to increase in the labile iron pool which plays roles in cholangiocarcinoma progression with aggressive clinical outcomes.	Iron	120-124	transferrin	Homo sapiens	34-45
28662118-15	2017	CONCLUSIONS: In this study, the iron status of serum ferritin &lt;90 ng/mL and transferrin saturation &gt;=20% was optimal in hemodialysis patients receiving recombinant human erythropoietin for anemia therapy.	Iron	32-36	erythropoietin	Homo sapiens	176-190
28638917-3	2017	Iron regulatory proteins (IRPs) including IRP1 and IRP2 are cytosolic proteins that play important roles in maintaining cellular iron homeostasis.	Iron	129-133	iron responsive element binding protein 2	Homo sapiens	51-55
29296759-3	2017	Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endocytosis of diferric-transferrin into recycling endosomes, where ferric iron is released, reduced, and exported to the cytosol via DMT1.	Iron	20-24	transferrin	Homo sapiens	58-69
29296759-3	2017	Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endocytosis of diferric-transferrin into recycling endosomes, where ferric iron is released, reduced, and exported to the cytosol via DMT1.	Iron	20-24	charged multivesicular body protein 2B	Homo sapiens	229-233
28638917-4	2017	F-box and leucine-rich repeat protein 5 (FBXL5) is involved in the regulation of iron metabolism by degrading IRP2 through the ubiquitin-proteasome system.	Iron	81-85	F-box and leucine rich repeat protein 5	Homo sapiens	41-46
28638917-4	2017	F-box and leucine-rich repeat protein 5 (FBXL5) is involved in the regulation of iron metabolism by degrading IRP2 through the ubiquitin-proteasome system.	Iron	81-85	iron responsive element binding protein 2	Homo sapiens	110-114
28642436-1	2017	The multifunctional protein cytochrome c (cyt c) plays key roles in electron transport and apoptosis, switching function by modulating bonding between a heme iron and the sulfur in a methionine residue.	Iron	158-162	cytochrome c, somatic	Homo sapiens	28-40
28642436-1	2017	The multifunctional protein cytochrome c (cyt c) plays key roles in electron transport and apoptosis, switching function by modulating bonding between a heme iron and the sulfur in a methionine residue.	Iron	158-162	cytochrome c, somatic	Homo sapiens	42-47
28557453-5	2017	Both partners of the fusion protein retained their functionality; the hydrophobin moiety enabled migration to a surfactant phase in an aqueous two-phase system, and the transferrin moiety was able to reversibly bind iron.	Iron	216-220	transferrin	Homo sapiens	169-180
28474881-0	2017	Remote Perturbations in Tertiary Contacts Trigger Ligation of Lysine to the Heme Iron in Cytochrome c.	Iron	81-85	cytochrome c, somatic	Homo sapiens	89-101
28680861-6	2017	Like its mammalian ortholog, Dictyostelium Nramp1 transports iron from the phagosome into the cytosol, whereas the paralog NrampB is located on the contractile vacuole and controls, together with Nramp1, the cellular iron homeostasis.	Iron	61-65	solute carrier family 11 member 1	Homo sapiens	43-49
28342427-1	2017	Transferrin (Tf) is an important protein responsible for circulating and transporting iron into cytoplasm.	Iron	86-90	transferrin	Homo sapiens	0-11
28342427-1	2017	Transferrin (Tf) is an important protein responsible for circulating and transporting iron into cytoplasm.	Iron	86-90	transferrin	Homo sapiens	13-15
28557454-3	2017	Coupling an iron mineral cathode with metallic lead in a galvanic cell increased lead release by 531 mug L-1 on average-a 9-fold increase over uniform corrosion in the absence of iron.	Iron	12-16	L1 cell adhesion molecule	Homo sapiens	105-108
28674546-6	2017	Here, we report the discovery that an Arabidopsis thaliana monothiol glutaredoxin S17 (AtGRXS17) plays a critical role in the plants ability to respond to iron deficiency stress and maintain redox homeostasis.	Iron	155-159	CAX-interacting protein 2	Arabidopsis thaliana	69-81
28664160-6	2017	Its application to the iron-sulfur cluster scaffold protein IscU, which has been suggested to function both as an ordered and a disordered form, allows us to distinguish evolutionary traces of the structured species, suggesting that, if present in the cell, the disordered form has not left evolutionary imprinting.	Iron	23-27	iron-sulfur cluster assembly enzyme	Homo sapiens	60-64
28474881-2	2017	In cytochrome c (cyt c), ligation of Met80 to the heme iron is critical for the protein"s electron-transfer (ET) function in oxidative phosphorylation and for suppressing its peroxidase activity in apoptosis.	Iron	55-59	cytochrome c, somatic	Homo sapiens	3-15
28474881-2	2017	In cytochrome c (cyt c), ligation of Met80 to the heme iron is critical for the protein"s electron-transfer (ET) function in oxidative phosphorylation and for suppressing its peroxidase activity in apoptosis.	Iron	55-59	cytochrome c, somatic	Homo sapiens	17-22
28607404-5	2017	Both MIL-101(Fe) and NH2-MIL-101(Fe) show highly effective removal of phosphates from aqueous solutions, and the concentration of phosphates decrease sharply from the initial 0.60 mg L-1 to 0.045 and 0.032 mg L-1, respectively, within just 30 min of exposure.	Iron	13-15	immunoglobulin kappa variable 1-16	Homo sapiens	7-10
28607404-5	2017	Both MIL-101(Fe) and NH2-MIL-101(Fe) show highly effective removal of phosphates from aqueous solutions, and the concentration of phosphates decrease sharply from the initial 0.60 mg L-1 to 0.045 and 0.032 mg L-1, respectively, within just 30 min of exposure.	Iron	33-35	immunoglobulin kappa variable 1-16	Homo sapiens	27-30
28638368-4	2017	Voltage production showed that ferrous iron of 100 muM facilitated MFC start-up compared to 150 muM, 200 muM, and without supplement of ferrous iron.	Iron	39-43	latexin	Homo sapiens	51-54
28450115-10	2017	An increase in the expression of IRP2 caused upregulation of intracellular iron as a result of the response to iron deficiency, whereas the protein was degraded under iron-rich conditions.	Iron	75-79	iron responsive element binding protein 2	Homo sapiens	33-37
28450115-10	2017	An increase in the expression of IRP2 caused upregulation of intracellular iron as a result of the response to iron deficiency, whereas the protein was degraded under iron-rich conditions.	Iron	111-115	iron responsive element binding protein 2	Homo sapiens	33-37
28450115-10	2017	An increase in the expression of IRP2 caused upregulation of intracellular iron as a result of the response to iron deficiency, whereas the protein was degraded under iron-rich conditions.	Iron	111-115	iron responsive element binding protein 2	Homo sapiens	33-37
28450115-11	2017	We found that iron-rich regions existed in ovarian endometrial cysts concomitantly with the high level of IRP2 expression, which should generally be decomposed upon an overload of iron.	Iron	14-18	iron responsive element binding protein 2	Homo sapiens	106-110
28450115-12	2017	We revealed that an insufficient level of oxygen in the cysts is the main factor for the unusual stabilization of IRP2 against iron-mediated degradation, which provides aberrant uptake of iron in ovarian endometrial stromal cells and can potentially lead to carcinogenesis.	Iron	127-131	iron responsive element binding protein 2	Homo sapiens	114-118
28450115-12	2017	We revealed that an insufficient level of oxygen in the cysts is the main factor for the unusual stabilization of IRP2 against iron-mediated degradation, which provides aberrant uptake of iron in ovarian endometrial stromal cells and can potentially lead to carcinogenesis.	Iron	188-192	iron responsive element binding protein 2	Homo sapiens	114-118
28137239-3	2017	Further, lactoferrin, a milk protein belonging to the transferrin family is now an established multi-functional iron-binding protein.	Iron	112-116	transferrin	Homo sapiens	54-65
29965343-3	2017	Species of iron in the raw coal sample, size-resolved particles and bottom ashes were analyzed by BCR sequential extraction method (community bureau of reference, BCR).	Iron	11-15	Rho GTPase activating protein at 1A	Drosophila melanogaster	98-101
28638368-4	2017	Voltage production showed that ferrous iron of 100 muM facilitated MFC start-up compared to 150 muM, 200 muM, and without supplement of ferrous iron.	Iron	31-43	latexin	Homo sapiens	51-54
28721153-8	2017	Lower iron concentration was associated with higher concentrations of hsCRP, IL-6 and fibrinogen.	Iron	6-10	interleukin 6	Homo sapiens	77-96
28626420-6	2017	Recent studies have suggested an important role of iron decrease of brain in RLS pathophysiology.	Iron	51-55	RLS1	Homo sapiens	77-80
28592572-9	2017	In the No-iron group, age above 24 months and weight-for-length z-score at baseline were associated with high CRP at endline.	Iron	10-14	C-reactive protein	Homo sapiens	110-113
28583206-12	2017	Interestingly, increasing iron levels increased viral titers; while reducing intracellular iron levels, either by NRAMP knock-down or using DFX, reduced viral titers.	Iron	91-95	solute carrier family 11 member 1	Homo sapiens	114-119
29113390-4	2017	Studying the correlation of serum bilirubin levels with iron, zinc, copper and high-sensitivity C-reactive protein, we found positive correlations for iron and zinc, and negative correlations for high-sensitivity C-reactive protein and copper in whole participants.	Iron	151-155	C-reactive protein	Homo sapiens	96-114
28335084-0	2017	Identification of new BMP6 pro-peptide mutations in patients with iron overload.	Iron	66-70	bone morphogenetic protein 6	Homo sapiens	22-26
28335084-4	2017	A recent seminal study by French authors has described three heterozygous missense mutations in BMP6 associated with mild to moderate late-onset iron overload (IO).	Iron	145-149	bone morphogenetic protein 6	Homo sapiens	96-100
28551638-12	2017	Since beta-catenin is also known to be a component of wingless/Int-1-Frizzled signaling that also leads to transcriptional c-MYC activation, the pathway found here might be alternatively used by melanoma cells for iron supply, necessary for cell proliferation.	Iron	214-218	Wnt family member 1	Homo sapiens	63-68
28281325-2	2017	To date, however, the expression of iron regulatory protein-2 (IRP2), which is known to regulate several iron metabolism proteins, has not been assessed in colorectal cancer.	Iron	36-40	iron responsive element binding protein 2	Homo sapiens	63-67
28568509-3	2017	Furthermore, iron-deficient patients in chronic heart failure with a serum ferritin of &lt;100 mug/l or &lt;300 mug/l with reduced transferrin saturation of &lt;20%, who were given intravenous iron showed improved clinical outcomes.	Iron	13-17	transferrin	Homo sapiens	131-142
28350624-9	2017	The size of aluminum and iron particles was &gt;=62 mum, whereas the size of 2 other metals, zinc and gold, was smaller, that is, &lt;20 mum.	Iron	25-29	latexin	Homo sapiens	52-55
28219768-1	2017	Mosaic mutant mice displaying functional dysfunction of Atp7a copper transporter (the Menkes ATPase) are an established animal model of Menkes disease and constitute a convenient tool for investigating connections between copper and iron metabolisms.	Iron	233-237	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	56-61
28276700-1	2017	Transferrin is one of the sources of iron that is most readily available to colonizing and invading pathogens.	Iron	37-41	transferrin	Homo sapiens	0-11
28281325-5	2017	The impact of suppressing IRP2 on cellular iron metabolism was also determined by using siRNA and by using the MEK inhibitor trametinib.	Iron	43-47	iron responsive element binding protein 2	Homo sapiens	26-30
28281325-8	2017	The MEK inhibitor trametinib suppressed IRP2 and this was associated with a suppression in TfR1 and the labile iron pool (LIP).	Iron	111-115	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
28294512-6	2017	In addition, other genetic determinants of iron status, such as variants in Matriptase-2 (TMPRSS6), have been shown to influence iron metabolism in chronic hemodialysis patients, most likely acting through hepcidin regulation.	Iron	43-47	transmembrane serine protease 6	Homo sapiens	76-88
28433798-2	2017	AIMS: The aim was to determine whether administration of erythropoietin without iron supplementation decreases iron load and morbidity.	Iron	111-115	erythropoietin	Homo sapiens	57-71
28433798-7	2017	EPO treatment decreased total serum iron concentration (p=0.035).	Iron	36-40	erythropoietin	Homo sapiens	0-3
28433798-10	2017	CONCLUSIONS: A 6-day course of EPO decreased the iron load in preterm infants.	Iron	49-53	erythropoietin	Homo sapiens	31-34
28433798-0	2017	Randomized trial of early erythropoietin supplementation after preterm birth: Iron metabolism and outcome.	Iron	78-82	erythropoietin	Homo sapiens	26-40
27600268-5	2017	In addition to erythrocytosis, the BGN Tg mice showed elevated hemoglobin concentrations, hematocrit values and enhanced total iron binding capacity, revealing a clinical picture of polycythemia.	Iron	127-131	biglycan	Mus musculus	35-38
28328181-3	2017	Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis.	Iron	162-166	interleukin 6	Homo sapiens	117-121
28328181-3	2017	Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis.	Iron	162-166	interleukin 6	Homo sapiens	117-121
28294512-6	2017	In addition, other genetic determinants of iron status, such as variants in Matriptase-2 (TMPRSS6), have been shown to influence iron metabolism in chronic hemodialysis patients, most likely acting through hepcidin regulation.	Iron	43-47	transmembrane serine protease 6	Homo sapiens	90-97
28294512-6	2017	In addition, other genetic determinants of iron status, such as variants in Matriptase-2 (TMPRSS6), have been shown to influence iron metabolism in chronic hemodialysis patients, most likely acting through hepcidin regulation.	Iron	129-133	transmembrane serine protease 6	Homo sapiens	76-88
28294512-6	2017	In addition, other genetic determinants of iron status, such as variants in Matriptase-2 (TMPRSS6), have been shown to influence iron metabolism in chronic hemodialysis patients, most likely acting through hepcidin regulation.	Iron	129-133	transmembrane serine protease 6	Homo sapiens	90-97
28328144-3	2017	Dialysis clinical practice guidelines recommend tailoring Fe therapy based on transferrin saturation and serum ferritin levels.	Iron	58-60	transferrin	Homo sapiens	78-89
28328181-3	2017	Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis.	Iron	46-50	interleukin 6	Homo sapiens	117-121
28410926-1	2017	Findings of increased hemoglobin inside the HDL proteome among persons with diabetes who have haptoglobin 2-2 genotype suggest that iron-induced lipid peroxidation may be involved in diabetic kidney disease.	Iron	132-136	haptoglobin	Homo sapiens	94-105
28387022-4	2017	Physiological iron balance is tightly controlled at the cellular and systemic level by iron regulatory proteins (IRP1, IRP2) and the iron regulatory hormone hepcidin, respectively.	Iron	14-18	iron responsive element binding protein 2	Homo sapiens	119-123
27925282-6	2017	The expression levels of iron storage protein L-ferritin and iron transport proteins, including transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin1 (FPN1), were also altered.	Iron	25-29	solute carrier family 40 member 1	Rattus norvegicus	182-186
27932449-8	2017	The inverse relation between baseline CRP and hepcidin levels and the haemoglobin response suggests that CRP or hepcidin measurements could influence decisions on whether iron should be given orally or intravenously.	Iron	171-175	C-reactive protein	Homo sapiens	38-41
27932449-8	2017	The inverse relation between baseline CRP and hepcidin levels and the haemoglobin response suggests that CRP or hepcidin measurements could influence decisions on whether iron should be given orally or intravenously.	Iron	171-175	C-reactive protein	Homo sapiens	105-108
28410926-5	2017	Iron was inversely associated with eGFR regardless of diabetes status.	Iron	0-4	epidermal growth factor receptor	Homo sapiens	35-39
28410926-8	2017	In contrast to hemoglobin, high iron and low HDLc were associated with a lower mean eGFR regardless of diabetes status.	Iron	32-36	epidermal growth factor receptor	Homo sapiens	84-88
28474046-0	2017	Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels.	Iron	64-68	CF transmembrane conductance regulator	Homo sapiens	92-96
28424258-3	2017	Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin"s diagnostic potential as an index of iron deficiency.Methods: We measured hemoglobin and serum hepcidin, ferritin, soluble transferrin receptor (sTfR), and C-reactive protein (CRP) at 14, 20, and 30 wk of gestation in a cohort of 395 Gambian women recruited to a randomized controlled trial.	Iron	0-4	C-reactive protein	Homo sapiens	425-443
28424258-3	2017	Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin"s diagnostic potential as an index of iron deficiency.Methods: We measured hemoglobin and serum hepcidin, ferritin, soluble transferrin receptor (sTfR), and C-reactive protein (CRP) at 14, 20, and 30 wk of gestation in a cohort of 395 Gambian women recruited to a randomized controlled trial.	Iron	0-4	C-reactive protein	Homo sapiens	445-448
28474046-4	2017	In this review CFTR and Slo1 BKCa channels are employed to discuss the possible heme-independent interplay between iron and CO. Our recent studies demonstrated a high-affinity Fe3+ site at the interface between the regulatory domain and intracellular loop 3 of CFTR.	Iron	115-119	CF transmembrane conductance regulator	Homo sapiens	15-19
28371325-1	2017	Capillary electrophoresis analysis of transferrin in human serum is used to assess genetic variants after desialylation with neuraminidase and iron saturation to reduce the complexity of the transferrin pattern and thus facilitate the recognition of transferrin polymorphisms.	Iron	143-147	transferrin	Homo sapiens	38-49
28371325-3	2017	With the carrier ampholytes used, peaks for iron saturated and iron depleted transferrin are monitored which indicates complexation of iron ions by carrier ampholytes.	Iron	63-67	transferrin	Homo sapiens	77-88
28371325-3	2017	With the carrier ampholytes used, peaks for iron saturated and iron depleted transferrin are monitored which indicates complexation of iron ions by carrier ampholytes.	Iron	63-67	transferrin	Homo sapiens	77-88
28474046-4	2017	In this review CFTR and Slo1 BKCa channels are employed to discuss the possible heme-independent interplay between iron and CO. Our recent studies demonstrated a high-affinity Fe3+ site at the interface between the regulatory domain and intracellular loop 3 of CFTR.	Iron	115-119	CF transmembrane conductance regulator	Homo sapiens	261-265
28588503-0	2017	Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
28342790-7	2017	Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores.	Iron	66-70	transferrin	Homo sapiens	42-53
28342790-7	2017	Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores.	Iron	113-117	transferrin	Homo sapiens	42-53
28342790-7	2017	Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores.	Iron	113-117	transferrin	Homo sapiens	42-53
28641663-0	2017	[Expression Changes of Hepcidin and Ferroportin 1 in Murine Model of Iron Overload].	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	36-49
28641663-11	2017	RT-PCR and Western blot analyses showed that the expressions of ferroportin 1 at mRNA and protein level were increased in the murine model of iron overload (P&lt;0.05).	Iron	142-146	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	64-77
28641663-13	2017	CONCLUSION: The expressions of hepcidin and ferroportin 1 are increase in a murine model of iron overload, which may be contributed to the suppression effect on erythropoiesis in bone marrow.	Iron	92-96	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	44-57
28417130-9	2017	The Fe isotopic composition can thus be useful for distinguishing these different types of anemias in CKD patients, i.e. ID anemia vs. erythropoietin-related anemia.	Iron	4-6	erythropoietin	Homo sapiens	135-149
28456385-1	2017	Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a form of Neurodegeneration with Brain Iron Accumulation (NBIA) associated with mutations in the pantothenate kinase 2 gene (PANK2).	Iron	98-102	pantothenate kinase 2	Homo sapiens	156-177
28456385-1	2017	Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a form of Neurodegeneration with Brain Iron Accumulation (NBIA) associated with mutations in the pantothenate kinase 2 gene (PANK2).	Iron	98-102	pantothenate kinase 2	Homo sapiens	184-189
28588503-2	2017	In a recent study, we demonstrated the iron regulatory hormone hepcidin reduces brain iron in iron-overloaded rats.	Iron	39-43	hepcidin antimicrobial peptide	Rattus norvegicus	63-71
28588503-2	2017	In a recent study, we demonstrated the iron regulatory hormone hepcidin reduces brain iron in iron-overloaded rats.	Iron	86-90	hepcidin antimicrobial peptide	Rattus norvegicus	63-71
28588503-2	2017	In a recent study, we demonstrated the iron regulatory hormone hepcidin reduces brain iron in iron-overloaded rats.	Iron	86-90	hepcidin antimicrobial peptide	Rattus norvegicus	63-71
28588503-3	2017	Therefore, we hypothesized that hepcidin might be able to reduce iron and then protect neurons from hemin or iron-mediated neurotoxicity in hemin-treated neuronal cells.	Iron	65-69	hepcidin antimicrobial peptide	Rattus norvegicus	32-40
28588503-3	2017	Therefore, we hypothesized that hepcidin might be able to reduce iron and then protect neurons from hemin or iron-mediated neurotoxicity in hemin-treated neuronal cells.	Iron	109-113	hepcidin antimicrobial peptide	Rattus norvegicus	32-40
28588503-4	2017	Here, we tested the hypothesis and demonstrated that ad-hepcidin and hepcidin peptide both have the ability to suppress the hemin-induced increase in LDH release and apoptotic cell numbers, to reduce cell iron and ferritin contents, and to inhibit expression of transferrin receptor 1, divalent metal transporter 1, and ferroportin 1 in hemin-treated neurons.	Iron	205-209	hepcidin antimicrobial peptide	Rattus norvegicus	56-64
28588503-4	2017	Here, we tested the hypothesis and demonstrated that ad-hepcidin and hepcidin peptide both have the ability to suppress the hemin-induced increase in LDH release and apoptotic cell numbers, to reduce cell iron and ferritin contents, and to inhibit expression of transferrin receptor 1, divalent metal transporter 1, and ferroportin 1 in hemin-treated neurons.	Iron	205-209	hepcidin antimicrobial peptide	Rattus norvegicus	69-77
28588503-5	2017	We conclude that hepcidin protects neuron from hemin-mediated injury by reducing iron via inhibition of expression of iron transport proteins.	Iron	81-85	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
28588503-5	2017	We conclude that hepcidin protects neuron from hemin-mediated injury by reducing iron via inhibition of expression of iron transport proteins.	Iron	118-122	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
28511672-12	2017	The mRNA levels of iron-responsive genes, such as CrNRAMP2, CrATX1, CrFTR1, and CrFEA1, were also remarkably reduced.	Iron	19-23	uncharacterized protein	Chlamydomonas reinhardtii	50-58
28511672-12	2017	The mRNA levels of iron-responsive genes, such as CrNRAMP2, CrATX1, CrFTR1, and CrFEA1, were also remarkably reduced.	Iron	19-23	uncharacterized protein	Chlamydomonas reinhardtii	60-66
28492233-1	2017	Mammalian A-type proteins, ISCA1 and ISCA2, are evolutionarily conserved proteins involved in iron-sulfur cluster (Fe-S) biogenesis.	Iron	94-98	iron-sulfur cluster assembly 2	Mus musculus	37-42
28334935-9	2017	In examining iron variant associations with glucose homeostasis, an iron-raising variant of TMPRSS6 was associated with lower HbA1c levels (P = 8.66 x 10-10).	Iron	13-17	transmembrane serine protease 6	Homo sapiens	92-99
28334935-9	2017	In examining iron variant associations with glucose homeostasis, an iron-raising variant of TMPRSS6 was associated with lower HbA1c levels (P = 8.66 x 10-10).	Iron	68-72	transmembrane serine protease 6	Homo sapiens	92-99
28505142-4	2017	To investigate the mechanism of mitochondrial staining, a new non-emissive compound, fac-[Re(CO)3(phen)L], with L = O2C(CH2)3((C5H5)Fe(C5H4), i.e., containing a ferrocenyl moiety, was synthetized and characterized (3).	Iron	132-134	FA complementation group C	Homo sapiens	85-88
28492233-1	2017	Mammalian A-type proteins, ISCA1 and ISCA2, are evolutionarily conserved proteins involved in iron-sulfur cluster (Fe-S) biogenesis.	Iron	115-119	iron-sulfur cluster assembly 2	Mus musculus	37-42
28492233-3	2017	Here we report that mouse ISCA1 and ISCA2 are Fe2S2-containing proteins that combine all features of Fe-S carrier proteins.	Iron	101-105	iron-sulfur cluster assembly 2	Mus musculus	36-41
28445059-0	2017	Iron-Catalyzed Dehydrogenative sp3-sp2 Coupling via Direct Oxidative C-H Activation of Acetonitrile.	Iron	0-4	Sp3 transcription factor	Homo sapiens	31-34
28350442-2	2017	We designed specific conjugates of the iron-binding and transport protein, transferrin (Tf), to combine the advantages of this serum-stable protein as a targeting agent for cancer cells with self-assembling polymers to act as carriers of cytotoxic drugs.	Iron	39-43	transferrin	Homo sapiens	75-86
28350442-2	2017	We designed specific conjugates of the iron-binding and transport protein, transferrin (Tf), to combine the advantages of this serum-stable protein as a targeting agent for cancer cells with self-assembling polymers to act as carriers of cytotoxic drugs.	Iron	39-43	transferrin	Homo sapiens	88-90
32263713-0	2017	Maghemite nanoparticles coated with human serum albumin: combining targeting by the iron-acquisition pathway and potential in photothermal therapies.	Iron	84-88	albumin	Homo sapiens	48-55
28475636-8	2017	Furthermore, the TaNAAT1, TaNAAT2 and TaDMAS1 genes were differentially regulated by plant Fe status and their expression was significantly upregulated in root tissues from day five onwards during a seven-day Fe deficiency treatment.	Iron	91-93	deoxymugineic acid synthase 1-A	Triticum aestivum	38-45
28475636-8	2017	Furthermore, the TaNAAT1, TaNAAT2 and TaDMAS1 genes were differentially regulated by plant Fe status and their expression was significantly upregulated in root tissues from day five onwards during a seven-day Fe deficiency treatment.	Iron	209-211	deoxymugineic acid synthase 1-A	Triticum aestivum	38-45
28445059-0	2017	Iron-Catalyzed Dehydrogenative sp3-sp2 Coupling via Direct Oxidative C-H Activation of Acetonitrile.	Iron	0-4	Sp2 transcription factor	Homo sapiens	35-38
28475636-9	2017	The identification and characterization of the TaNAAT1, TaNAAT2 and TaDMAS1 genes provides a valuable genetic resource for improving bread wheat growth on Fe deficient soils and enhancing grain Fe nutrition.	Iron	155-157	deoxymugineic acid synthase 1-A	Triticum aestivum	68-75
28475636-9	2017	The identification and characterization of the TaNAAT1, TaNAAT2 and TaDMAS1 genes provides a valuable genetic resource for improving bread wheat growth on Fe deficient soils and enhancing grain Fe nutrition.	Iron	194-196	deoxymugineic acid synthase 1-A	Triticum aestivum	68-75
28445059-1	2017	An iron-catalyzed dehydrogenative sp3-sp2 coupling of acetonitrile and 2-arylimidazo[1,2-a]pyridine has been realized, which can serve as a novel approach toward heteroarylacetonitriles.	Iron	3-7	Sp3 transcription factor	Homo sapiens	34-37
28445059-1	2017	An iron-catalyzed dehydrogenative sp3-sp2 coupling of acetonitrile and 2-arylimidazo[1,2-a]pyridine has been realized, which can serve as a novel approach toward heteroarylacetonitriles.	Iron	3-7	Sp2 transcription factor	Homo sapiens	38-41
28418677-4	2017	Moreover, UV-visible absorption and resonance Raman spectra reveal that the conformational ensemble of membrane bound cytochrome c is dominated by a mixture of conformers with pentacoordinated and hexacoordinated high-spin heme irons, which contrast with the dominance of low-spin species at neutral pH.	Iron	228-233	cytochrome c, somatic	Homo sapiens	118-130
27696069-0	2017	Investigation of the relationship between hemoglobin and serum iron levels and early-phase insulin secretion in non-diabetic subjects: statistical and methodological issues.	Iron	63-67	insulin	Homo sapiens	91-98
28409923-5	2017	A discrete group of protonable residues are contained within a 15 A sphere surrounding the heme iron, and a computational analysis reveals that the pKa of the distal His112, alone, is modulated within the pH range of catalase activity by the remote acidic residues in a pattern consistent with its protonated form having a key role in the catalase reaction cycle.	Iron	96-100	catalase	Homo sapiens	217-225
28409923-5	2017	A discrete group of protonable residues are contained within a 15 A sphere surrounding the heme iron, and a computational analysis reveals that the pKa of the distal His112, alone, is modulated within the pH range of catalase activity by the remote acidic residues in a pattern consistent with its protonated form having a key role in the catalase reaction cycle.	Iron	96-100	catalase	Homo sapiens	339-347
28453699-13	2017	Conclusion: The miRNA binding site SNP rs1062980 in iron regulatory pathway, which may alter the expression of IREB2 potentially through modulating the binding of miR-29a, together with dietary iron intake may modify risk of LC both individually and jointly.	Iron	52-56	iron responsive element binding protein 2	Homo sapiens	111-116
28476795-8	2017	In conclusion, increased iron in cancer cells and their microenvironment protects cancer cells from natural killer cell cytolysis by antagonizing NO- and TNFalpha-associated cytotoxicity and by up-regulation of ferritin expression in breast cancer cells.	Iron	25-29	tumor necrosis factor	Homo sapiens	154-162
28160681-2	2017	The results show that the soluble iron in the investigated water samples was sufficiently effective for reaction with H2O2 in the simulated rainwater-affected stagnant water to produce OH (Fenton reaction), which inactivated coliform bacteria even at a H2O2 dose as low as 5 muM within just 1 min of contact time.	Iron	34-38	latexin	Homo sapiens	275-278
27125837-3	2017	Our aim was to determine whether IFNL polymorphisms in CHC patients associate with body iron indices, and whether they are linked with hepatic expression of genes involved in iron homeostasis and IFN signaling.	Iron	88-92	interferon alpha 1	Homo sapiens	33-36
27125837-12	2017	IFNL polymorphisms influence regulatory pathways of cellular response to IFN and affect body iron balance in chronic hepatitis C virus infection.	Iron	93-97	interferon alpha 1	Homo sapiens	0-3
28167288-7	2017	Quantitative real-time polymerase chain reaction demonstrated significant dysregulation of genes involved in iron and heme metabolism, including Hmox1, Fech, Abcb7, and Sf3b1 downregulation.	Iron	109-113	heme oxygenase 1	Mus musculus	145-150
28622776-6	2017	On the other hand, iron affect innate immune responses by influencing IFN-gamma or NF-kB pathways in macrophages.	Iron	19-23	interferon gamma	Homo sapiens	70-79
28282554-1	2017	Erythroferrone (ERFE) and TMPRSS6 are important proteins in the regulation of iron metabolism.	Iron	78-82	transmembrane serine protease 6	Rattus norvegicus	26-33
28282554-2	2017	The objective of the study was to examine splenic ERFE and liver TMPRSS6 synthesis in rats treated with a combination of iron and erythropoietin (EPO).	Iron	121-125	transmembrane serine protease 6	Rattus norvegicus	65-72
28282554-5	2017	Iron pretreatment prevented the EPO-induced decrease in hepcidin expression.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	56-64
28282554-10	2017	The results confirm that iron pretreatment prevents the EPO-induced decrease in liver Hamp expression.	Iron	25-29	hepcidin antimicrobial peptide	Rattus norvegicus	86-90
28306566-2	2017	RECENT FINDINGS: We review the benefits and risks of EPO-stimulating agents, focusing on health-related quality of life and the uncertainties regarding optimal iron utilization in patients with kidney disease.	Iron	160-164	erythropoietin	Homo sapiens	53-56
28453699-13	2017	Conclusion: The miRNA binding site SNP rs1062980 in iron regulatory pathway, which may alter the expression of IREB2 potentially through modulating the binding of miR-29a, together with dietary iron intake may modify risk of LC both individually and jointly.	Iron	194-198	iron responsive element binding protein 2	Homo sapiens	111-116
28263291-7	2017	In in vitro experiments using EPO-producing HepG2 cells, iron stimulation reduced the expression of the EPO gene, as well as HIF-2alpha.	Iron	57-61	erythropoietin	Homo sapiens	30-33
27659401-12	2017	The increase in uric acid associated with hyperferritinemia, could be a response to the visceral toxicity of excess non-transferrin bound iron linked to oxidative stress via the antioxidant properties of uric acid.	Iron	138-142	transferrin	Homo sapiens	120-131
28414228-2	2017	Ferrous ion supplied by the ferroportin exporter is converted by Cp to ferric ion that is accepted by plasma metallo-chaperone transferrin.	Iron	71-81	transferrin	Homo sapiens	127-138
28375153-0	2017	PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.	Iron	35-39	poly(rC) binding protein 1	Mus musculus	0-5
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	26-30	poly(rC) binding protein 1	Mus musculus	42-67
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	26-30	poly(rC) binding protein 1	Mus musculus	69-74
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	94-98	poly(rC) binding protein 1	Mus musculus	42-67
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	94-98	poly(rC) binding protein 1	Mus musculus	69-74
28375153-6	2017	Using a cultured cell model of erythroid differentiation, depletion of PCBP1 or NCOA4 impaired iron trafficking through ferritin, which resulted in reduced heme synthesis, reduced hemoglobin formation, and perturbation of erythroid regulatory systems.	Iron	95-99	poly(rC) binding protein 1	Mus musculus	71-76
28375153-8	2017	Ex vivo differentiation of erythroid precursors from Pcbp1-deficient mice confirmed defects in ferritin iron flux and heme synthesis.	Iron	104-108	poly(rC) binding protein 1	Mus musculus	53-58
28375153-9	2017	These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin.	Iron	173-177	poly(rC) binding protein 1	Mus musculus	144-149
28347462-6	2017	The influence of Mn on Fe homeostasis may be mediated through its influence on Fe absorption, circulating transporters like transferrin, and regulatory proteins.	Iron	23-25	transferrin	Homo sapiens	124-135
28347462-10	2017	Numerous data also demonstrate the possibility of competition between Fe and chromium (Cr) for transferrin binding.	Iron	70-72	transferrin	Homo sapiens	95-106
28263291-7	2017	In in vitro experiments using EPO-producing HepG2 cells, iron stimulation reduced the expression of the EPO gene, as well as HIF-2alpha.	Iron	57-61	erythropoietin	Homo sapiens	104-107
28584599-2	2017	The aim of this study was to determine the relationship between iron, ferritin, and hepcidin levels in diabetic patients and the effect of insulin treatment.	Iron	64-68	insulin	Homo sapiens	139-146
28284907-0	2017	Minocycline protects, rescues and prevents knockdown transgenic parkin Drosophila against paraquat/iron toxicity: Implications for autosomic recessive juvenile parkinsonism.	Iron	99-103	parkin	Drosophila melanogaster	64-70
28284907-1	2017	Autosomal recessive Juvenile Parkinsonism (AR-JP) is a chronic, progressive neurodegenerative disorder caused by mutation in the PARKIN gene, and invariably associated with dopaminergic (DAergic) neuronal loss and brain iron accumulation.	Iron	220-224	parkin	Drosophila melanogaster	129-135
28426710-1	2017	Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism.	Iron	212-216	solute carrier family 40 member 1	Rattus norvegicus	92-105
28341433-1	2017	Herein we report on a drastic release of metal ions from the Fe-bound transferrin, and Fe- or Mn-bound lactoferrin, observed upon the increase in the separation voltage during CE-based analysis.	Iron	61-63	transferrin	Homo sapiens	70-81
28426710-1	2017	Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	37-45
28426710-1	2017	Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism.	Iron	66-70	solute carrier family 40 member 1	Rattus norvegicus	92-105
28426710-1	2017	Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism.	Iron	66-70	solute carrier family 40 member 1	Rattus norvegicus	107-111
28426710-1	2017	Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism.	Iron	212-216	hepcidin antimicrobial peptide	Rattus norvegicus	37-45
27742903-8	2017	In WMW, Cp ( r = -0.182; p &gt; 0.05) and FRAP ( r = 0.277; p &lt; 0.05) negatively and positively correlated with Pb, respectively, while a positive correlation was observed between zinc ( r = 0.230; p &lt; 0.05) and Pb and between Cu ( r = 0.541; p &gt; 0.001) and Fe.	Iron	267-269	mechanistic target of rapamycin kinase	Homo sapiens	42-46
28426710-1	2017	Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism.	Iron	212-216	solute carrier family 40 member 1	Rattus norvegicus	107-111
28469631-10	2017	Yeast complementation tests indicated that PtIRT1, PtZIP1, PtZIP2, PtZIP3, and PtZIP12 were able to complement the zrt1zrt2 mutant, which was deficient in Zn uptake; PtIRT1 and PtZIP7 were able to complement the fet3fet4 mutant, which was deficient in Fe uptake, and PtIRT1 was able to complement the smf1 mutant, which was deficient in Mn uptake, suggesting their respective functions in Zn, Fe, and Mn transport.	Iron	393-395	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	115-123
28469631-10	2017	Yeast complementation tests indicated that PtIRT1, PtZIP1, PtZIP2, PtZIP3, and PtZIP12 were able to complement the zrt1zrt2 mutant, which was deficient in Zn uptake; PtIRT1 and PtZIP7 were able to complement the fet3fet4 mutant, which was deficient in Fe uptake, and PtIRT1 was able to complement the smf1 mutant, which was deficient in Mn uptake, suggesting their respective functions in Zn, Fe, and Mn transport.	Iron	252-254	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	115-123
28491880-3	2017	This entity is caused by mutants of the TMPRSS6 gene that encodes the protein matriptase II, which influences hepcidin expression, an iron metabolism counterregulatory protein.	Iron	134-138	transmembrane serine protease 6	Homo sapiens	40-47
28187348-1	2017	Ferrous iron/peroxymonosulfate (Fe(II)/PMS) oxidation was employed as a pretreatment method for ultrafiltration process to control membrane fouling caused by natural organic matter, including humic acid (HA), sodium alginate (SA), bovine serum albumin (BSA), and their mixture (HA-SA-BSA).	Iron	0-12	albumin	Homo sapiens	238-251
28257842-5	2017	Angiotensin II (AngII)-mediated increases in ROS and free iron levels were also attenuated in cardiomyocytes isolated from PICOT TG mice but exacerbated in cardiomyocytes from PICOT KD mice.	Iron	58-62	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-14
28257842-5	2017	Angiotensin II (AngII)-mediated increases in ROS and free iron levels were also attenuated in cardiomyocytes isolated from PICOT TG mice but exacerbated in cardiomyocytes from PICOT KD mice.	Iron	58-62	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	16-21
28257842-7	2017	Taken together, these data show that PICOT alleviates myocardial I/R injury by regulating intracellular ROS and free iron levels.	Iron	117-121	glutaredoxin 3	Mus musculus	37-42
28213091-2	2017	Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production.	Iron	0-4	aryl-hydrocarbon receptor	Mus musculus	19-22
28213091-2	2017	Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production.	Iron	6-8	aryl-hydrocarbon receptor	Mus musculus	19-22
28380382-2	2017	Recent studies have shown that the co-chaperone HSC20, essential for Fe-S cluster biogenesis of SDHB, directly binds LYRM7, formerly described as a chaperone that stabilizes UQCRFS1 prior to its insertion into CIII.	Iron	69-73	LYR motif containing 7	Homo sapiens	117-122
28421043-5	2017	Systems approaches reveal that, in aerobiosis, the PMF-independent respiratory dehydrogenase NdhII is induced in response to the reduction in intracellular levels of iron.	Iron	166-170	DExH-box helicase 9	Homo sapiens	93-98
28404645-1	2017	IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which is critical to intracellular iron homeostasis and which relates to the rate of cellular proliferation.	Iron	30-34	iron responsive element binding protein 2	Homo sapiens	0-5
28404645-1	2017	IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which is critical to intracellular iron homeostasis and which relates to the rate of cellular proliferation.	Iron	30-34	iron responsive element binding protein 2	Homo sapiens	57-61
28404645-6	2017	A cohort of operated NSCLC patients was studied for markers of systemic iron status, tumour IRP2 staining and survival.Iron loading caused cell proliferation in cancer cell lines, which were less able to regulate IREB2 expression than PBECs.	Iron	119-123	iron responsive element binding protein 2	Homo sapiens	92-96
28404645-6	2017	A cohort of operated NSCLC patients was studied for markers of systemic iron status, tumour IRP2 staining and survival.Iron loading caused cell proliferation in cancer cell lines, which were less able to regulate IREB2 expression than PBECs.	Iron	119-123	iron responsive element binding protein 2	Homo sapiens	213-218
28404645-8	2017	IRP2-positive tumours were larger (p=0.045) and higher percentage staining related to poorer survival (p=0.079).Loss of iron regulation represents a poor prognostic marker in lung cancer.	Iron	120-124	iron responsive element binding protein 2	Homo sapiens	0-4
28219939-4	2017	We have confirmed that Prx1 from the puffer fish and humans truly possesses a catalase (CAT)-like activity that is independent of Cys residues and reductants, but dependent on iron.	Iron	176-180	catalase	Homo sapiens	78-86
28219939-4	2017	We have confirmed that Prx1 from the puffer fish and humans truly possesses a catalase (CAT)-like activity that is independent of Cys residues and reductants, but dependent on iron.	Iron	176-180	catalase	Homo sapiens	88-91
28380382-3	2017	Here we report that a transient subcomplex involved in CIII assembly, composed of LYRM7 bound to UQCRFS1, interacts with components of an Fe-S transfer complex, consisting of HSC20, its cognate chaperone HSPA9, and the holo-scaffold ISCU.	Iron	138-140	LYR motif containing 7	Homo sapiens	82-87
28380382-3	2017	Here we report that a transient subcomplex involved in CIII assembly, composed of LYRM7 bound to UQCRFS1, interacts with components of an Fe-S transfer complex, consisting of HSC20, its cognate chaperone HSPA9, and the holo-scaffold ISCU.	Iron	138-140	heat shock protein family A (Hsp70) member 9	Homo sapiens	204-209
28380382-3	2017	Here we report that a transient subcomplex involved in CIII assembly, composed of LYRM7 bound to UQCRFS1, interacts with components of an Fe-S transfer complex, consisting of HSC20, its cognate chaperone HSPA9, and the holo-scaffold ISCU.	Iron	138-140	iron-sulfur cluster assembly enzyme	Homo sapiens	233-237
28318177-0	2017	Can soluble transferrin receptor be used in diagnosing iron deficiency anemia and assessing iron response in infants with moderate acute malnutrition?	Iron	55-59	transferrin	Homo sapiens	12-23
28287409-0	2017	Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.	Iron	29-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Iron	61-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	158-162
28287409-5	2017	The reduction in nuclear NRF2 leads to reduced ferroportin 1 (FPN1) expression, which in turn results in decreased cellular iron export.	Iron	124-128	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
28287409-5	2017	The reduction in nuclear NRF2 leads to reduced ferroportin 1 (FPN1) expression, which in turn results in decreased cellular iron export.	Iron	124-128	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	47-60
28287409-5	2017	The reduction in nuclear NRF2 leads to reduced ferroportin 1 (FPN1) expression, which in turn results in decreased cellular iron export.	Iron	124-128	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	62-66
28287409-8	2017	Taken together, our results uncover a link between sirtuin proteins and direct control over cellular iron homeostasis via regulation of NRF2 deacetylation and stability.	Iron	101-105	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
28318177-1	2017	OBJECTIVE: To evaluate the efficacy of soluble transferrin receptor (sTfR) in diagnosing iron deficiency anemia (IDA) and evaluating iron response in infants with moderate acute malnutrition (MAM).	Iron	89-93	transferrin	Homo sapiens	47-58
28233916-9	2017	We also found a generalized decrease in the amount of the iron-binding proteins transferrin and ceruloplasmin, and decreased number of neurons and glial cells that contained ceruloplasmin.	Iron	58-62	transferrin	Homo sapiens	80-91
26926576-12	2017	The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (-22% and +18%, respectively, p &lt; 0.05).	Iron	34-38	paraoxonase 1	Homo sapiens	140-145
28281897-9	2017	Pharmacological targeting of iron metabolism (iron chelation, transferrin receptor blocking) altered the cytokine release profile.	Iron	29-33	transferrin	Homo sapiens	62-73
27942883-1	2017	A recessive mutation in PLA2G6, which is known to cause infantile neuroaxonal dystrophy (INAD) and neurodegeneration associated with brain iron accumulation (NBIA), has recently been shown to be responsible for PARK14-linked dystonia-parkinsonism.	Iron	139-143	phospholipase A2 group VI	Homo sapiens	24-30
28315258-4	2017	In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively.	Iron	89-93	Aft2p	Saccharomyces cerevisiae S288C	66-70
27936457-7	2017	The combination of iron overload (Hfe-/-) and defective antioxidant defences (Nrf2-/-) increased the number of iron-related necroinflammatory lesions (sideronecrosis), possibly due to the accumulation of toxic oxidation products such as 4-hydroxy-2-nonenal-protein adducts.	Iron	111-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
27936457-10	2017	CONCLUSIONS: The genetic disruption of Nrf2 promotes the transition from iron accumulation (siderosis) to liver injury in Hfe-/- mice, representing the first demonstration of spontaneous hepatic fibrosis in the long term in a mouse model of hereditary hemochromatosis displaying mildly elevated liver iron.	Iron	73-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
27936457-10	2017	CONCLUSIONS: The genetic disruption of Nrf2 promotes the transition from iron accumulation (siderosis) to liver injury in Hfe-/- mice, representing the first demonstration of spontaneous hepatic fibrosis in the long term in a mouse model of hereditary hemochromatosis displaying mildly elevated liver iron.	Iron	301-305	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
27936457-3	2017	In mice, transcription factor NRF2 is a critical determinant of hepatocyte viability during exposure to acute dietary iron overload.	Iron	118-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
28315258-4	2017	In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively.	Iron	133-137	Aft2p	Saccharomyces cerevisiae S288C	66-70
28219045-1	2017	Matriptase-2, a type II transmembrane serine protease (TTSP), is expressed in the liver and regulates iron homeostasis via the cleavage of hemojuvelin.	Iron	102-106	transmembrane serine protease 6	Homo sapiens	0-12
28219045-2	2017	Matriptase-2 emerges as an attractive target for the treatment of conditions associated with iron overload, such as hemochromatosis or beta-thalassemia.	Iron	93-97	transmembrane serine protease 6	Homo sapiens	0-12
28219045-6	2017	Such compounds represent useful pharmacological tools to test matriptase-2 inhibition in a context of iron overload.	Iron	102-106	transmembrane serine protease 6	Homo sapiens	62-74
28315258-7	2017	Various conserved proteins, such as ABC mitochondrial transporter Atm1 and, for Aft1/Aft2, monothiol glutaredoxins Grx3 and Grx4 are implicated in this iron-signaling pathway.	Iron	152-156	Aft2p	Saccharomyces cerevisiae S288C	85-89
28315258-7	2017	Various conserved proteins, such as ABC mitochondrial transporter Atm1 and, for Aft1/Aft2, monothiol glutaredoxins Grx3 and Grx4 are implicated in this iron-signaling pathway.	Iron	152-156	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	124-128
28421781-4	2017	Results: Traditional porridges from Honduras (PTH) showed low density of micronutrients being the PTH prepared based on "rice with beans and greens", "rice with ground beans" and "beans with banana" which had a higher content values of 1.96, 1.56, and 1.46 mg Fe/100 g, respectively, although in vitroavailability values below 50% of its content.	Iron	260-262	parathyroid hormone	Homo sapiens	46-49
28069738-1	2017	FBXL5 is the substrate recognition subunit of an SCF-type ubiquitin ligase that serves as a master regulator of iron metabolism in mammalian cells.	Iron	112-116	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
28405169-10	2017	This study proposes that lysosomal leakage is a novel pathway of TGF-beta1-induced EMT that may be prevented by iron-chelating drugs that target the lysosome.	Iron	112-116	transforming growth factor beta 1	Homo sapiens	65-74
28271877-4	2017	The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for FeS cluster formation.	Iron	141-144	LYR motif containing 4	Homo sapiens	9-14
28271877-4	2017	The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for FeS cluster formation.	Iron	141-144	iron-sulfur cluster assembly enzyme	Homo sapiens	63-67
28189691-4	2017	Therefore, we developed human IgG monoclonal antibodies to human TFR1 using a phage display method (ICOS method) to block the incorporation of the transferrin (TF)-iron complex into ATLL cells for inhibiting cell growth.	Iron	164-168	transferrin	Homo sapiens	147-158
28189691-4	2017	Therefore, we developed human IgG monoclonal antibodies to human TFR1 using a phage display method (ICOS method) to block the incorporation of the transferrin (TF)-iron complex into ATLL cells for inhibiting cell growth.	Iron	164-168	transferrin	Homo sapiens	65-67
28296633-0	2017	The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.	Iron	133-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-88
28300826-5	2017	In this paradigm, activated glial cells are the source of IL-6, which was essential in the iron overload-activated apoptosis of neurons.	Iron	91-95	interleukin 6	Homo sapiens	58-62
28300826-7	2017	Together, our data are consistent with a model whereby inflammation initiates an intercellular signaling cascade in which activated microglia, through IL-6 signaling, stimulate astrocytes to release hepcidin which, in turn, signals to neurons, via hepcidin, to prevent their iron release.	Iron	275-279	interleukin 6	Homo sapiens	151-155
28327200-2	2017	Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow transferrin-mediated iron transport to the bone marrow.	Iron	159-163	transferrin	Homo sapiens	138-149
28004401-8	2017	Agents such as iron chelators, and heavy metals like cobalt and nickel were demonstrated to be effective in maintaining the HIF-1alpha level in the nerve.	Iron	15-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
28065783-3	2017	By using diphtheria toxin (DT) as a model toxin, we found that mutating the Tf protein to change its iron release rate improves cellular association and efficacy of the drug.	Iron	101-105	transferrin	Homo sapiens	76-78
28262683-0	2017	Thermodynamics and Equations of State of Iron to 350 GPa and 6000 K. The equations of state for solid (with bcc, fcc, and hcp structures) and liquid phases of Fe were defined via simultaneous optimization of the heat capacity, bulk moduli, thermal expansion, and volume at room and higher temperatures.	Iron	41-45	glycophorin A (MNS blood group)	Homo sapiens	53-56
28002754-8	2017	Finally, we found that uptake of aggregation-prone iron nanomedicines by peripheral blood mononuclear cells in whole blood induced production of the proinflammatory cytokine IL-1beta, but not IL-6.	Iron	51-55	interleukin 1 beta	Homo sapiens	174-182
28287443-7	2017	Moreover, our results indicated marked enhancement of antioxidant potential, as well as iron chelation activities, in HHP-treated patatin as compared with NP.	Iron	88-92	Patatin class I	Solanum tuberosum	130-137
28439220-2	2017	The reference values for transferrin saturation have been previously reported to be lower in children compared to adults, caused by a combination of low serum iron and high serum transferrin levels in children, warranting specific reference intervals.	Iron	159-163	transferrin	Homo sapiens	25-36
28229980-9	2017	Oral iron supplementation brought more obvious improvements of iron status indicators including absolute increases in serum iron (11.08 +- 2.19 mumol/L vs. 4.43 +- 0.47 mumol/L), transferrin saturation (11.26 +- 1.65% vs. 1.01 +- 0.23%), and hemoglobin (31.47 +- 1.19 g/L vs. 21.00 +- 2.69 g/L) in the acupuncture group than control group (all P &lt; 0.05).	Iron	5-9	transferrin	Homo sapiens	179-190
28257476-12	2017	Non-transferrin-bound iron was high in the thalassemia and MDS groups but low in the SCA group (P&lt;0.001).	Iron	22-26	transferrin	Homo sapiens	4-15
28357393-0	2017	Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae.	Iron	35-39	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	27-31
28357393-6	2017	The activation with iron is dependent on Ftr1 and with zinc on Zrt1, and we show that it is independent of intracellular iron and zinc levels.	Iron	20-24	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	63-67
28357393-7	2017	Similar to the transceptors for macronutrients, Ftr1 and Zrt1 are strongly induced upon iron and zinc starvation, respectively, and they are rapidly downregulated by substrate-induced endocytosis.	Iron	88-92	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	57-61
27896489-2	2017	We investigated the effects of Fe and its concentration in beta-tricalcium phosphate (beta-TCP) on physicomechanical properties and in vitro proliferation and differentiation of osteoblasts.	Iron	31-33	serine peptidase inhibitor Kazal type 1	Homo sapiens	91-94
27896489-3	2017	Our results showed that Fe addition at concentrations of 0.5 wt.% (0.5 Fe-TCP) and 1.0 wt.% (1.0 Fe-TCP) inhibits the beta-TCP to alpha-TCP phase transformation at sintering temperature of 1250  C. Addition of 0.25 wt.% Fe (0.25 Fe-TCP) increased the compressive strength of beta-TCP from 167.27 +- 16.2 to 227.10 +- 19.3 MPa.	Iron	24-26	serine peptidase inhibitor Kazal type 1	Homo sapiens	74-77
27896489-3	2017	Our results showed that Fe addition at concentrations of 0.5 wt.% (0.5 Fe-TCP) and 1.0 wt.% (1.0 Fe-TCP) inhibits the beta-TCP to alpha-TCP phase transformation at sintering temperature of 1250  C. Addition of 0.25 wt.% Fe (0.25 Fe-TCP) increased the compressive strength of beta-TCP from 167.27 +- 16.2 to 227.10 +- 19.3 MPa.	Iron	24-26	serine peptidase inhibitor Kazal type 1	Homo sapiens	100-103
27896489-3	2017	Our results showed that Fe addition at concentrations of 0.5 wt.% (0.5 Fe-TCP) and 1.0 wt.% (1.0 Fe-TCP) inhibits the beta-TCP to alpha-TCP phase transformation at sintering temperature of 1250  C. Addition of 0.25 wt.% Fe (0.25 Fe-TCP) increased the compressive strength of beta-TCP from 167.27 +- 16.2 to 227.10 +- 19.3 MPa.	Iron	24-26	serine peptidase inhibitor Kazal type 1	Homo sapiens	100-103
27896489-3	2017	Our results showed that Fe addition at concentrations of 0.5 wt.% (0.5 Fe-TCP) and 1.0 wt.% (1.0 Fe-TCP) inhibits the beta-TCP to alpha-TCP phase transformation at sintering temperature of 1250  C. Addition of 0.25 wt.% Fe (0.25 Fe-TCP) increased the compressive strength of beta-TCP from 167.27 +- 16.2 to 227.10 +- 19.3 MPa.	Iron	24-26	serine peptidase inhibitor Kazal type 1	Homo sapiens	100-103
27896489-3	2017	Our results showed that Fe addition at concentrations of 0.5 wt.% (0.5 Fe-TCP) and 1.0 wt.% (1.0 Fe-TCP) inhibits the beta-TCP to alpha-TCP phase transformation at sintering temperature of 1250  C. Addition of 0.25 wt.% Fe (0.25 Fe-TCP) increased the compressive strength of beta-TCP from 167.27 +- 16.2 to 227.10 +- 19.3 MPa.	Iron	24-26	serine peptidase inhibitor Kazal type 1	Homo sapiens	100-103
27896489-3	2017	Our results showed that Fe addition at concentrations of 0.5 wt.% (0.5 Fe-TCP) and 1.0 wt.% (1.0 Fe-TCP) inhibits the beta-TCP to alpha-TCP phase transformation at sintering temperature of 1250  C. Addition of 0.25 wt.% Fe (0.25 Fe-TCP) increased the compressive strength of beta-TCP from 167.27 +- 16.2 to 227.10 +- 19.3 MPa.	Iron	24-26	serine peptidase inhibitor Kazal type 1	Homo sapiens	100-103
27896489-3	2017	Our results showed that Fe addition at concentrations of 0.5 wt.% (0.5 Fe-TCP) and 1.0 wt.% (1.0 Fe-TCP) inhibits the beta-TCP to alpha-TCP phase transformation at sintering temperature of 1250  C. Addition of 0.25 wt.% Fe (0.25 Fe-TCP) increased the compressive strength of beta-TCP from 167.27 +- 16.2 to 227.10 +- 19.3 MPa.	Iron	71-73	serine peptidase inhibitor Kazal type 1	Homo sapiens	74-77
27896489-7	2017	Our results show that Fe concentration had significant effect on physical and mechanical properties of TCP ceramics, and also on the in vitro osteoblast cellular interactions in TCP ceramics.	Iron	22-24	serine peptidase inhibitor Kazal type 1	Homo sapiens	103-106
27896489-7	2017	Our results show that Fe concentration had significant effect on physical and mechanical properties of TCP ceramics, and also on the in vitro osteoblast cellular interactions in TCP ceramics.	Iron	22-24	serine peptidase inhibitor Kazal type 1	Homo sapiens	178-181
27550154-6	2017	Correlation analysis showed that trace elements Mn, Fe, Ni, Ga, Se, Sr, Cs, U in water and Co, Ni, Cu, Se, U in feed were significantly correlated with those in milk (p &lt; 0.05).	Iron	52-54	Weaning weight-maternal milk	Bos taurus	161-165
28068635-6	2017	Interestingly, the IP6 was found to down-regulate the mRNA expression of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta, and IL-6 in iron overloaded liver tissues.	Iron	144-148	tumor necrosis factor	Mus musculus	73-106
28068635-6	2017	Interestingly, the IP6 was found to down-regulate the mRNA expression of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta, and IL-6 in iron overloaded liver tissues.	Iron	144-148	interleukin 1 beta	Mus musculus	108-130
28068635-6	2017	Interestingly, the IP6 was found to down-regulate the mRNA expression of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta, and IL-6 in iron overloaded liver tissues.	Iron	144-148	interleukin 6	Mus musculus	136-140
28128726-3	2017	Intravenous iron was given at each site"s discretion if ferritin &lt;= 1,000 ng/mL and transferrin saturation &lt;= 30%.	Iron	12-16	transferrin	Homo sapiens	87-98
28128726-5	2017	Multivariable generalized estimating equations related elevated ESA and intravenous iron doses to trailing 90-day averages of ferritin and transferrin saturation with covariate adjustment.	Iron	84-88	transferrin	Homo sapiens	139-150
28128726-8	2017	Adjusted odds ratios for higher intravenous iron dose were lower in the highest (0.23 [0.16 - 0.35], p &lt; 0.001) and middle transferrin saturation tertile (0.42 [0.31 - 0.57], p &lt; 0.001) vs. lowest.	Iron	44-48	transferrin	Homo sapiens	126-137
28128726-11	2017	Transferrin saturation may be a better marker than serum ferritin to judge optimal iron stores in dialysis patients.	Iron	83-87	transferrin	Homo sapiens	0-11
28087888-3	2017	We investigated whether hepcidin, a key hormone regulating iron metabolism, could be involved in this deleterious effect.	Iron	59-63	hepcidin antimicrobial peptide	Rattus norvegicus	24-32
28075490-1	2017	BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive.	Iron	131-135	transferrin	Homo sapiens	64-75
28087888-6	2017	In agreement with the biological role of hepcidin, we found a decrease of circulating iron and an increase of spleen iron content in hindlimb-unloaded rats.	Iron	86-90	hepcidin antimicrobial peptide	Rattus norvegicus	41-49
28087888-6	2017	In agreement with the biological role of hepcidin, we found a decrease of circulating iron and an increase of spleen iron content in hindlimb-unloaded rats.	Iron	117-121	hepcidin antimicrobial peptide	Rattus norvegicus	41-49
28087888-7	2017	Consequently, our study supports the idea that hepcidin could play a role in the alteration of iron metabolism parameters observed during spaceflight.	Iron	95-99	hepcidin antimicrobial peptide	Rattus norvegicus	47-55
28087888-11	2017	Herein, we hypothesized that microgravity upregulates hepcidin, a hormone produced by the liver that is the main controller of iron homeostasis.	Iron	127-131	hepcidin antimicrobial peptide	Rattus norvegicus	54-62
28087888-14	2017	In agreement with the biological role of hepcidin, we found an increase of spleen iron content (+78%, P = 0.030) and a decrease of serum iron concentration (-35%, P = 0.002) and transferrin saturation (-25%, P = 0.011) in HU rats.	Iron	82-86	hepcidin antimicrobial peptide	Rattus norvegicus	41-49
28087888-14	2017	In agreement with the biological role of hepcidin, we found an increase of spleen iron content (+78%, P = 0.030) and a decrease of serum iron concentration (-35%, P = 0.002) and transferrin saturation (-25%, P = 0.011) in HU rats.	Iron	137-141	hepcidin antimicrobial peptide	Rattus norvegicus	41-49
28087888-15	2017	These findings support a role of hepcidin in microgravity-induced iron metabolism alteration.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	33-41
28087888-17	2017	Taken together, these data support the idea that microgravity may alter iron metabolism through an inflammatory process upregulating hepcidin.	Iron	72-76	hepcidin antimicrobial peptide	Rattus norvegicus	133-141
28149019-9	2017	Serum iron levels were higher at low CD4 levels.	Iron	6-10	CD4 molecule	Homo sapiens	37-40
28110161-0	2017	Citrate and albumin facilitate transferrin iron loading in the presence of phosphate.	Iron	43-47	transferrin	Homo sapiens	31-42
28110161-2	2017	Serum transferrin binds iron in a non-exchangeable form and delivers iron to cells.	Iron	24-28	transferrin	Homo sapiens	6-17
28110161-2	2017	Serum transferrin binds iron in a non-exchangeable form and delivers iron to cells.	Iron	69-73	transferrin	Homo sapiens	6-17
28110161-4	2017	This work evaluates possible pathways leading to LPI and examines potential mediators of apo transferrin iron loading to prevent LPI.	Iron	105-109	transferrin	Homo sapiens	93-104
28110161-5	2017	Previously phosphate was shown to inhibit iron loading into apo transferrin by competitively binding free Fe3+.	Iron	42-46	transferrin	Homo sapiens	64-75
28110161-7	2017	In this study we evaluate iron loading into transferrin under physiologically relevant phosphate conditions to evaluate the roles of citrate and albumin in mediating iron delivery into apo transferrin.	Iron	26-30	transferrin	Homo sapiens	44-55
28110161-7	2017	In this study we evaluate iron loading into transferrin under physiologically relevant phosphate conditions to evaluate the roles of citrate and albumin in mediating iron delivery into apo transferrin.	Iron	166-170	transferrin	Homo sapiens	189-200
28110161-14	2017	Our results suggest a physiologically important role for albumin and citrate for apo transferrin iron loading.	Iron	97-101	transferrin	Homo sapiens	85-96
30148572-11	2017	The predicted values were in good accordance with those determined with inductively coupled plasma atomic emission spectroscopy(ICP-AES) method when the iron ion concentration was above 0.4 mg L-1, which could be used to ascertain the existence of fluorescence quenching agent and their corresponding concentration.	Iron	153-157	immunoglobulin kappa variable 1-16	Homo sapiens	193-196
28257033-2	2017	This protein of the transferrin family has broad antimicrobial properties by depriving pathogens from iron, or disrupting their plasma membranes through its highly cationic charge.	Iron	102-106	transferrin	Homo sapiens	20-31
28272038-6	2017	One of the graft polymers, GPA-2, exhibits excellent adsorption properties able to remove metal ions like cadmium, cobalt, copper, lead, iron and also organic impurities like chlorophenol and phthalic anhydride.	Iron	137-141	glycoprotein hormone subunit alpha 2	Homo sapiens	27-32
28446734-10	2017	Over the last two decades, many clinical investigations have been conducted on clinical effectiveness of treatment of iron deficiency or anemia with oral iron, intravenous iron, and erythropoietin therapies.	Iron	118-122	erythropoietin	Homo sapiens	182-196
28140480-2	2017	Hepcidin is a recently discovered acute-phase protein (APP) that plays an important role in iron metabolism and contributes to the development of anemia in humans with CKD.	Iron	92-96	amyloid beta precursor protein	Homo sapiens	34-53
28248850-10	2017	CONCLUSION: Early parenteral iron supplementation combined erythropoietin in preterm infants improved the percentages of reticulocyte, decreased total iron binding capacity, and improved the Hb and MCV levels at 3 months of age.	Iron	29-33	erythropoietin	Homo sapiens	59-73
28248850-10	2017	CONCLUSION: Early parenteral iron supplementation combined erythropoietin in preterm infants improved the percentages of reticulocyte, decreased total iron binding capacity, and improved the Hb and MCV levels at 3 months of age.	Iron	151-155	erythropoietin	Homo sapiens	59-73
27794191-6	2017	This increased intracellular iron complexed to quercetin does not associate with the labile iron pool and cells behave as though they are iron deficient (increased transferrin receptor-1 and iron regulatory protein-2 expression and low ferritin expression).	Iron	29-33	iron responsive element binding protein 2	Homo sapiens	191-216
28994539-7	2017	The results demonstrated that Siwu decoction had a certain effect on improving iron deficiency anemia in infant rats, and the mechanism may be associated with the regulatory effect of hepcidin iron metabolism.	Iron	79-83	hepcidin antimicrobial peptide	Rattus norvegicus	184-192
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	holocytochrome c synthase	Homo sapiens	27-52
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	holocytochrome c synthase	Homo sapiens	54-58
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	cytochrome c, somatic	Homo sapiens	136-141
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	cytochrome c, somatic	Homo sapiens	145-150
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	holocytochrome c synthase	Homo sapiens	258-262
28174761-5	2017	From their Raman spectra apo-and holo-forms of iron-binding proteins, transferrin and ferritin, could be readily distinguished and variations in spectral features as a result of structural changes could also be determined.	Iron	47-51	transferrin	Homo sapiens	70-81
28031261-8	2017	Our results demonstrate that ceruloplasmin decreases the bioavailability of iron in urine by a transferrin-dependent mechanism.	Iron	76-80	transferrin	Homo sapiens	95-106
28955733-10	2017	GENERAL SIGNIFICANCE: These results suggest that exogenous PP IX disrupts iron metabolism by decreasing the protein expression levels of PAP7, DMT1 and C/EBPalpha.	Iron	74-78	CCAAT enhancer binding protein alpha	Homo sapiens	152-162
28220853-1	2017	For the first time, renewable and easy accessible pre-bleached spent coffee powder coated with polyethylenimine (PEI) and ferric ions (Coffee-PEI-Fe) was used for the successive adsorption of As(V), Cu(II) and P(V) ions from spiked water samples.	Iron	146-148	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	192-197
28192915-7	2017	The instrument is applicable for multielement analysis, and the LODs ranged from 0.16 to 11.65 mug L-1 for Zn, Pb, Ag, Cd, Au, Cu, Mn, Fe, Cr, and As.	Iron	135-137	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
28230785-2	2017	ROS-derived hydroperoxides, as an indicator of ROS production, have been measured by using the diacron reactive oxygen metabolites (d-ROMs) test, which requires iron-containing transferrin in the reaction mixture.	Iron	161-165	transferrin	Homo sapiens	177-188
28131773-0	2017	Redox sensing molecular mechanism of an iron metabolism regulatory protein FBXL5.	Iron	40-44	F-box and leucine rich repeat protein 5	Homo sapiens	75-80
27718450-2	2017	Human serum transferrin is the most abundant serum protein responsible for the transport of iron ions and many endogenous and exogenous ligands.	Iron	92-96	transferrin	Homo sapiens	12-23
28228829-10	2017	Hepatic Mcp-1 and Tnf-alpha mRNA levels were significantly lower in the CR compared with the HFD (74 and 47% lower) and showed significantly negative correlations with hepatic non-heme iron levels (Mcp-1: r = -0.557, P &lt; 0.05; Tnf-alpha: r = -0.464, P &lt; 0.05).	Iron	185-189	mast cell protease 1	Mus musculus	8-13
28228829-10	2017	Hepatic Mcp-1 and Tnf-alpha mRNA levels were significantly lower in the CR compared with the HFD (74 and 47% lower) and showed significantly negative correlations with hepatic non-heme iron levels (Mcp-1: r = -0.557, P &lt; 0.05; Tnf-alpha: r = -0.464, P &lt; 0.05).	Iron	185-189	tumor necrosis factor	Mus musculus	18-27
28261264-1	2017	Mutations in WDR45 gene, coding for a beta-propeller protein, have been found in patients affected by Neurodegeneration with Brain Iron Accumulation, NBIA5 (also known as BPAN).	Iron	131-135	WD repeat domain 45	Homo sapiens	13-18
28261264-1	2017	Mutations in WDR45 gene, coding for a beta-propeller protein, have been found in patients affected by Neurodegeneration with Brain Iron Accumulation, NBIA5 (also known as BPAN).	Iron	131-135	WD repeat domain 45	Homo sapiens	150-155
28261264-2	2017	BPAN is a movement disorder with Non Transferrin Bound Iron (NTBI) accumulation in the basal ganglia as common hallmark between NBIA classes (Hayflick et al., 2013).	Iron	55-59	transferrin	Homo sapiens	37-48
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	signal transducer and activator of transcription 3	Homo sapiens	289-294
27847325-0	2017	An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots.	Iron	115-119	multidrug resistance-associated protein 2	Arabidopsis thaliana	15-30
27847325-9	2017	Here, we provide compelling evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots.	Iron	158-160	aluminum sensitive 3	Arabidopsis thaliana	50-54
28131773-1	2017	FBXL5 is a subunit of the SCFFBXL5 ubiquitin ligase complex that targets the proteasomal degradation of iron regulatory protein IRP2, which is an important regulator in iron metabolism.	Iron	104-108	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
28131773-1	2017	FBXL5 is a subunit of the SCFFBXL5 ubiquitin ligase complex that targets the proteasomal degradation of iron regulatory protein IRP2, which is an important regulator in iron metabolism.	Iron	104-108	iron responsive element binding protein 2	Homo sapiens	128-132
28131773-2	2017	The degradation of FBXL5 itself is regulated in an iron- and oxygen-responsive manner through its diiron center containing Hr-like domain.	Iron	51-55	F-box and leucine rich repeat protein 5	Homo sapiens	19-24
28131773-3	2017	Although the crystal structure of the Hr-like domain of FBXL5 and its degradation based on iron/oxygen sensing has been reported, the redox sensing molecular mechanism is still not clear.	Iron	91-95	F-box and leucine rich repeat protein 5	Homo sapiens	56-61
28131773-6	2017	The redox reactions of the diiron center are accompanied with conformational changes and iron release, which are associated with FBXL5 stability and degradation.	Iron	29-33	F-box and leucine rich repeat protein 5	Homo sapiens	129-134
28131773-7	2017	These results provide insights into the redox sensing mechanism by which FBXL5 can serve as an iron metabolism regulator within mammalian cells.	Iron	95-99	F-box and leucine rich repeat protein 5	Homo sapiens	73-78
28174279-7	2017	Conditional deletion of both Bcl9 and Bcl9l or both Pygo1 and Pygo2 in mice produced teeth with defective enamel that was bright white and deficient in iron, which is reminiscent of human tooth enamel pathologies.	Iron	152-156	B cell CLL/lymphoma 9	Mus musculus	29-33
29964510-11	2017	The maximum concentrations of iron, manganese, ammonium and sulfide in the summer of the El Nino year were 0.38, 1.36, 2.36 and 1.67 mg L-1, respectively.	Iron	30-34	immunoglobulin kappa variable 1-16	Homo sapiens	136-139
32263872-4	2017	This PCP/uPA nanosystem was formed through the crosslinking between chitosan (CS) and poly(N-isopropylacrylamide) (PNIPAM), followed by surface decoration with polyethylene glycol (mPEG) and a breast cancer targeting peptide uPA, which was then used to encapsulate metal complexes (RuPOP and Fe(PiP)3) to solve their bottleneck of low solubility and stability under physiological conditions.	Iron	292-294	plasminogen activator, urokinase	Homo sapiens	9-12
27770299-5	2017	The addition of iron ions to concentrations of 1 and 10 mg Fe2+ L-1 repressed the finger-type structure and filamentous out-growth.	Iron	16-20	immunoglobulin kappa variable 1-16	Homo sapiens	64-67
28166223-4	2017	The first is that overexpression of iron regulatory protein 2 (IRP2) recapitulates many aspects of the alterations in free iron and iron-related proteins in cancer cells without affecting the oxidative stress response or the oncogenic pathways included in the model.	Iron	36-40	iron responsive element binding protein 2	Homo sapiens	63-67
28166223-4	2017	The first is that overexpression of iron regulatory protein 2 (IRP2) recapitulates many aspects of the alterations in free iron and iron-related proteins in cancer cells without affecting the oxidative stress response or the oncogenic pathways included in the model.	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	36-61
28166223-4	2017	The first is that overexpression of iron regulatory protein 2 (IRP2) recapitulates many aspects of the alterations in free iron and iron-related proteins in cancer cells without affecting the oxidative stress response or the oncogenic pathways included in the model.	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	63-67
28052885-3	2017	Studies evaluating the effect of milk fortification on iron and vitamin D status in these children are scarce.	Iron	55-59	Weaning weight-maternal milk	Bos taurus	33-37
27810529-6	2017	After 6 h of the Fenton reaction at pH 3, the addition of 1660 mg L-1 of H2O2 and 133 mg L-1 of iron showed a maximum O&amp;G elimination of 57.6% and a phenol removal up to 80%.	Iron	96-100	L1 cell adhesion molecule	Homo sapiens	66-77
27853903-6	2017	mTOR as the common signaling pathway between cancer and neurodegenerative disorders controls iron uptake and it is in active form in both diseases.	Iron	93-97	mechanistic target of rapamycin kinase	Homo sapiens	0-4
27853903-7	2017	Anti-cancer drugs which target mTOR causes iron deficiency and dual effects of mTOR inhibitors can candidate them as a therapeutic strategy to alleviate neurodegeneration/inflammation because of iron overloading.	Iron	43-47	mechanistic target of rapamycin kinase	Homo sapiens	31-35
27927281-1	2017	The phosphorus (P) adsorption properties of an iron [Fe(0)]-rich substrate (IRS) composed of iron scraps and activated carbon were investigated based on iron-carbon micro-electrolysis (IC-ME) and compared to the substrates commonly used in constructed wetlands (CWs) to provide an initial characterization of the [Fe(0)]-rich substrate.	Iron	47-51	isoleucyl-tRNA synthetase 1	Homo sapiens	76-79
27848940-3	2017	Iron is reported to induce hypophosphataemia in rare cases, and recent reports suggest that iron deficiency may upregulate FGF23 synthesis by mechanisms involving hypoxia-inducible factor 1alpha (HIF1alpha).	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	196-205
27927281-1	2017	The phosphorus (P) adsorption properties of an iron [Fe(0)]-rich substrate (IRS) composed of iron scraps and activated carbon were investigated based on iron-carbon micro-electrolysis (IC-ME) and compared to the substrates commonly used in constructed wetlands (CWs) to provide an initial characterization of the [Fe(0)]-rich substrate.	Iron	53-58	isoleucyl-tRNA synthetase 1	Homo sapiens	76-79
27927281-3	2017	The adsorption capacity of the IRS decreased by only 4.6% in the second round of adsorption due to Fe(0) consumption in the first round.	Iron	99-104	isoleucyl-tRNA synthetase 1	Homo sapiens	31-34
27927281-6	2017	The IRS with an iron scrap to activated carbon volume ratio of 3:2 resulted in the highest P adsorption capacity (9.34 +- 0.14 g P kg-1), with minimal pH change and strong adaptability to OM accumulation.	Iron	16-20	isoleucyl-tRNA synthetase 1	Homo sapiens	4-7
27852449-4	2017	Calculations for FeS-coated limestone dissolution experiments show that the process can be described as nCa.sol = At1/2 - nCa,gyp.	Iron	17-20	CEA cell adhesion molecule 4	Homo sapiens	104-107
27852449-4	2017	Calculations for FeS-coated limestone dissolution experiments show that the process can be described as nCa.sol = At1/2 - nCa,gyp.	Iron	17-20	CEA cell adhesion molecule 4	Homo sapiens	122-125
27685251-1	2017	Dysmetabolic iron overload syndrome (DIOS) is a common cause of hyperferritinemia, accounting for a mild increase of iron stores in insulin-resistant subjects.	Iron	13-17	insulin	Homo sapiens	132-139
28143953-7	2017	The expression levels of hemoglobin-haptoglobin receptor CD163 and hemopexin receptor CD91 were drastically reduced in both liver and spleen, resulting in heme- and hemoglobin-derived iron elimination in urine.	Iron	184-188	CD163 antigen	Mus musculus	57-62
28007574-4	2017	Our results suggest that Slt2 form iron/sulphur bridged clusters with Grx3 and Grx4.	Iron	35-39	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	79-83
27685251-2	2017	Iron removal could improve insulin sensitivity.	Iron	0-4	insulin	Homo sapiens	27-34
27986638-2	2017	The well-studied transferrins are mammalian serum transferrin, which is involved in iron transport, and mammalian lactoferrin, which functions as an immune protein.	Iron	84-88	transferrin	Homo sapiens	17-28
27986638-9	2017	Unlike iron-saturated lactoferrin, iron-saturated transferrin had no detectable antibacterial activity.	Iron	35-39	transferrin	Homo sapiens	50-61
27986638-10	2017	In contrast, 1 muM iron-free transferrin inhibited bacterial growth, and this inhibition was blocked by supplementing the culture medium with 1 muM iron.	Iron	19-23	transferrin	Homo sapiens	29-40
27986638-10	2017	In contrast, 1 muM iron-free transferrin inhibited bacterial growth, and this inhibition was blocked by supplementing the culture medium with 1 muM iron.	Iron	148-152	transferrin	Homo sapiens	29-40
27986638-11	2017	Our results suggest that M. sexta transferrin does not have bactericidal activity, but that it does have a bacteriostatic function that depends on its iron sequestering ability.	Iron	151-155	transferrin	Homo sapiens	34-45
27986638-12	2017	This study supports the hypothesis that insect transferrin participates in an iron withholding strategy to protect insects from infectious bacteria.	Iron	78-82	transferrin	Homo sapiens	47-58
27865123-5	2017	Log10 reduction on corroded iron pipe wall coupons ranged from 1.0 to 2.9 at respective chlorine dioxide concentrations of 5 and 25 mg L-1, although spores were undetectable on the iron surface during disinfection at 25 mg L-1.	Iron	28-32	immunoglobulin kappa variable 1-16	Homo sapiens	135-138
27537429-11	2017	In the groups of TNBS colitis and moderate or high iron administration, both agents again significantly worsen the degree of inflammation despite the significant reduction in the t-TNF-alpha and t-MDA.	Iron	51-55	tumor necrosis factor	Rattus norvegicus	181-190
27416847-1	2017	Objective Hepcidin regulates iron availability and may be responsible for the anemia of chronic disease because it is induced by interleukin-6.	Iron	29-33	interleukin 6	Homo sapiens	129-142
27473364-10	2017	CONCLUSION: Among the investigated indicators of iron metabolism, serum transferrin concentration was the best indicator of organ failure and an independent predictor of short-term mortality at 30 days.	Iron	49-53	transferrin	Homo sapiens	72-83
27735062-6	2017	Fe starvation triggered Moco biosynthesis and affected the molybdo-enzymes, with its main impact on nitrate reductase and xanthine dehydrogenase, both being involved in nitrogen assimilation and mobilization, and on the mitochondrial amidoxime reducing component.	Iron	0-2	nitrate reductase [NADH]-like	Cucumis sativus	100-117
28161108-0	2017	Rv0774c, an iron stress inducible, extracellular esterase is involved in immune-suppression associated with altered cytokine and TLR2 expression.	Iron	12-16	toll like receptor 2	Homo sapiens	129-133
27826939-0	2017	A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice.	Iron	8-12	superoxide dismutase 1, soluble	Mus musculus	125-129
27826939-1	2017	The aim of the present study was to evaluate the therapeutic effect of the novel neuroprotective multitarget brain permeable monoamine oxidase inhibitor/iron chelating-radical scavenging drug, VAR10303 (VAR), co-administered with high-calorie/energy-supplemented diet (ced) in SOD1G93A transgenic amyotrophic lateral sclerosis (ALS) mice.	Iron	153-157	superoxide dismutase 1, soluble	Mus musculus	277-281
28032976-3	2017	Unlike pentacoordinate flavohemoglobins, which are efficient NODs, THB1 uses two iron axial ligands: the conserved proximal histidine and a distal lysine (Lys53).	Iron	81-85	uncharacterized protein	Chlamydomonas reinhardtii	67-71
27801963-0	2017	NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana.	Iron	57-61	nucleotide binding protein 35	Arabidopsis thaliana	0-5
27957820-1	2017	Serum ferritin level and transferrin saturation (TSAT) are widely used to evaluate iron status in patients with chronic kidney disease, and are also important variables for performing statistical analyses.	Iron	83-87	transferrin	Homo sapiens	25-36
28112296-4	2017	In the absence of bicarbonate the affinity of transferrin for plutonium at pH 6 is about 104 times stronger than that of iron at pH 6.7 .	Iron	121-125	transferrin	Homo sapiens	46-57
28405327-8	2017	Finally, serum ferritin and liver iron concentration were significantly correlated with liver dysfunction determined by AST and ALT.	Iron	34-38	solute carrier family 17 member 5	Homo sapiens	120-123
28055968-4	2017	AT101 is a well-established BCL-2 homology domain 3 (BH3) mimetic that we recently demonstrated functions as an iron chelator and thus acts as a hypoxia mimetic.	Iron	112-116	BCL2 apoptosis regulator	Homo sapiens	28-33
28008752-0	2017	High levels of iron supplementation prevents neural tube defects in the Fpn1ffe mouse model.	Iron	15-19	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	72-76
28139717-12	2017	Preventing iron depletion protected from BclxL downregulation and deferasirox cytotoxicity.	Iron	11-15	BCL2 like 1	Homo sapiens	41-46
28008752-4	2017	Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.	Iron	34-38	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	60-72
28008752-4	2017	Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.	Iron	34-38	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	74-78
28008752-4	2017	Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.	Iron	104-108	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	60-72
28008752-4	2017	Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.	Iron	104-108	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	74-78
28008752-7	2017	RESULTS: High levels of iron supplementation significantly reduced the incidence of NTDs in Fpn1ffe mutants.	Iron	24-28	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	92-96
28008752-12	2017	CONCLUSION: Our results demonstrate that iron supplementation can prevent NTDs and forebrain truncations in the Fpn1ffe model.	Iron	41-45	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	112-116
28139717-0	2017	Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells.	Iron	20-24	BCL2 like 1	Homo sapiens	44-49
28139717-13	2017	In conclusion, deferasirox promoted iron depletion-dependent cell death characterized by BclxL downregulation.	Iron	36-40	BCL2 like 1	Homo sapiens	89-94
28139717-14	2017	BclxL overexpression was protective, suggesting a role for BclxL downregulation in iron depletion-induced cell death.	Iron	83-87	BCL2 like 1	Homo sapiens	0-5
28139717-14	2017	BclxL overexpression was protective, suggesting a role for BclxL downregulation in iron depletion-induced cell death.	Iron	83-87	BCL2 like 1	Homo sapiens	59-64
28120861-0	2017	Intracellular degradation of functionalized carbon nanotube/iron oxide hybrids is modulated by iron via Nrf2 pathway.	Iron	60-64	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
27903529-0	2017	Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis.	Iron	58-62	bone morphogenetic protein 2	Mus musculus	11-15
27903529-6	2017	Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2fl/fl (Bmp2LSECKO) mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis.	Iron	114-118	bone morphogenetic protein 2	Mus musculus	43-47
27903529-6	2017	Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2fl/fl (Bmp2LSECKO) mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis.	Iron	114-118	bone morphogenetic protein 2	Mus musculus	71-75
27903529-6	2017	Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2fl/fl (Bmp2LSECKO) mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis.	Iron	161-165	bone morphogenetic protein 2	Mus musculus	43-47
27903529-6	2017	Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2fl/fl (Bmp2LSECKO) mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis.	Iron	161-165	bone morphogenetic protein 2	Mus musculus	43-47
27903529-8	2017	Thus, angiocrine Bmp2 signaling within the hepatic vascular niche represents a constitutive pathway indispensable for iron homeostasis in vivo that is nonredundant with Bmp6.	Iron	118-122	bone morphogenetic protein 2	Mus musculus	17-21
27842714-0	2017	Offshore sediments record the history of onshore iron ore mining in Goa State, India.	Iron	49-53	tripartite motif containing 47	Homo sapiens	68-71
28135344-11	2017	These results support the prevailing hypothesis that erythroferrone is a promising erythroid regulator and demonstrate that Erfe expression is stimulated most strongly when the iron supply to developing erythroid cells is compromised.	Iron	177-181	erythroferrone	Mus musculus	124-128
28120861-5	2017	CNT exposure activates an oxidative stress-dependent production of iron via Nrf2 nuclear translocation, Ferritin H and Heme oxygenase 1 translation.	Iron	67-71	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
28120861-6	2017	Conversely, Bach1 was translocated to the nucleus of cells exposed to iron-loaded CNTs to recycle embedded iron.	Iron	70-74	BTB domain and CNC homolog 1	Homo sapiens	12-17
28120861-6	2017	Conversely, Bach1 was translocated to the nucleus of cells exposed to iron-loaded CNTs to recycle embedded iron.	Iron	107-111	BTB domain and CNC homolog 1	Homo sapiens	12-17
26852252-1	2017	Arsenate (As(V)) removal ability by nanoscale zero-valent iron (nZVI) is compromised by aggregation of nZVI particles.	Iron	58-62	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-15
28118841-0	2017	Copper chelation and interleukin-6 proinflammatory cytokine effects on expression of different proteins involved in iron metabolism in HepG2 cell line.	Iron	116-120	interleukin 6	Homo sapiens	21-34
28118841-4	2017	RESULTS: We show that copper deficiency and the inflammatory cytokine interleukin-6 have different effects on the expression of proteins involved in iron and copper metabolism such as the soluble and glycosylphosphtidylinositol anchored forms of ceruloplasmin, hepcidin, ferroportin1, transferrin receptor1, divalent metal transporter1 and H-ferritin subunit.	Iron	149-153	interleukin 6	Homo sapiens	70-83
28001042-9	2017	In an in vitro reaction, the reduced form of each ferredoxin was found to support Fe-S cluster assembly on ISCU; the rate of cluster assembly was faster with FDX2 than with FDX1.	Iron	82-86	iron-sulfur cluster assembly enzyme	Homo sapiens	107-111
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	ATP binding cassette subfamily B member 10	Homo sapiens	186-192
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	iron responsive element binding protein 2	Homo sapiens	233-238
28054602-0	2017	Identification of Guanosine 5"-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.	Iron	56-60	interleukin 6	Homo sapiens	139-152
28059071-1	2017	Secondary active transporters of the SLC11/NRAMP family catalyse the uptake of iron and manganese into cells.	Iron	79-83	solute carrier family 11 member 1	Homo sapiens	43-48
28054602-0	2017	Identification of Guanosine 5"-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.	Iron	56-60	signal transducer and activator of transcription 3	Homo sapiens	153-159
29474757-2	2017	Iron supplementation leads to a rise of transferrin saturation and ferritin concentration, resulting in an increased hemoglobin level and decrease of anemia symptoms.	Iron	0-4	transferrin	Homo sapiens	40-51
29142965-14	2017	Discussion: It is suggested that not only iron load but also the erythropoiesis-stimulating agent dose reduction may be involved in ferritin elevation during ferric citrate hydrate treatment, resulting in a decrease of erythropoietin resistance index.	Iron	42-46	erythropoietin	Homo sapiens	219-233
27838686-5	2017	The comparison between pre- and post-chelation demonstrated significantly lower iron load: median serum ferritin (551.4 vs. 486.2 ng/ml, p = 0.047), median TIBC (211.5 vs. 233.5 microg/dl, p = 0.009) and median non-transferrin binding iron (5.5 vs. 1.4 microM, p = 0.005).	Iron	80-84	transferrin	Homo sapiens	215-226
27281365-11	2017	Another contributing factor to carcinogenesis is the excessive consumption of red meat containing redox-active iron (Fe+3) that initiates parafibrin formation from blood fibrinogen.	Iron	111-115	fibrinogen beta chain	Homo sapiens	170-180
28395333-2	2017	The fetal kidney renin-angiotensin system (RAS) is involved in nephrogenesis, fluid balance, and iron deposition.	Iron	97-101	renin	Homo sapiens	17-22
29226154-6	2017	In UC, transferrin correlates negatively with CRP, erythrocyte sedimentation rate (ESR), leukocytes, platelets, interleukin-6, interleukin-10, and TNF-alpha and positively with albumins, cholesterol, hemoglobin, hematocrit, erythrocytes, iron, and paraoxonase-1.	Iron	238-242	transferrin	Homo sapiens	7-18
27281365-11	2017	Another contributing factor to carcinogenesis is the excessive consumption of red meat containing redox-active iron (Fe+3) that initiates parafibrin formation from blood fibrinogen.	Iron	117-119	fibrinogen beta chain	Homo sapiens	170-180
28191453-0	2017	Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion.	Iron	53-57	tumor necrosis factor	Homo sapiens	5-8
27686598-7	2017	The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1).	Iron	14-18	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	239-243
28191453-0	2017	Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion.	Iron	53-57	interleukin 6	Homo sapiens	108-112
28191453-5	2017	This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin production and the levels of its main regulators, leading to a restoration of iron homeostasis.	Iron	165-169	tumor necrosis factor	Homo sapiens	34-37
28191453-14	2017	Anti-TNF therapy improves iron metabolism and, subsequently, anaemia in IBD.	Iron	26-30	tumor necrosis factor	Homo sapiens	5-8
27718428-9	2017	The high reactivity and stability of ZVI showed its suitability for in-situ prevention of As(V) and Se(VI) migration due to accidental leakage, spillage, or overflow of flowback water.	Iron	37-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
27718428-1	2017	Zero-valent iron (ZVI) was tested for the removal of 150 mug L-1 As(V) and 350 mug L-1 Se(VI) in high-salinity (ionic strength 0.35-4.10 M) flowback water of hydraulic fracturing.	Iron	12-16	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
27718428-1	2017	Zero-valent iron (ZVI) was tested for the removal of 150 mug L-1 As(V) and 350 mug L-1 Se(VI) in high-salinity (ionic strength 0.35-4.10 M) flowback water of hydraulic fracturing.	Iron	18-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
27796971-9	2017	PHREEQC inverse geochemical models showed throughout the upper and middle basin, that about 1.5 mmol L-1 of Fe-bearing minerals were precipitated.	Iron	108-110	immunoglobulin kappa variable 1-16	Homo sapiens	101-104
27718428-2	2017	Over 90% As(V) and Se(VI) was removed by 2.5 g L-1 ZVI in Day-14 flowback water up to 96-h reaction, with the remaining concentration below the maximum contaminant level for As(V) and criterion continuous concentration for Se(VI) recommended by US EPA.	Iron	51-54	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-14
27718428-2	2017	Over 90% As(V) and Se(VI) was removed by 2.5 g L-1 ZVI in Day-14 flowback water up to 96-h reaction, with the remaining concentration below the maximum contaminant level for As(V) and criterion continuous concentration for Se(VI) recommended by US EPA.	Iron	51-54	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	174-179
27718428-6	2017	The competition between As(V) and Se(VI) for ZVI removal depended on the initial molar ratio and surface sites, which occurred when the Se(VI) concentration was higher than the As(V) concentration in this study.	Iron	45-48	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
27718428-6	2017	The competition between As(V) and Se(VI) for ZVI removal depended on the initial molar ratio and surface sites, which occurred when the Se(VI) concentration was higher than the As(V) concentration in this study.	Iron	45-48	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	177-182
27718428-7	2017	The characterization of As(V)- and Se(VI)-loaded ZVI by X-ray diffraction and Raman analysis revealed that ZVI gradually converted to magnetite/maghemite corrosion products with lepidocrocite in flowback water over 30 days.	Iron	49-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
27718428-7	2017	The characterization of As(V)- and Se(VI)-loaded ZVI by X-ray diffraction and Raman analysis revealed that ZVI gradually converted to magnetite/maghemite corrosion products with lepidocrocite in flowback water over 30 days.	Iron	107-110	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
28240188-7	2017	Moreover, Fe levels were negatively associated with Hp and positively with PON1, total iron binding capacity and Tf, while ferritin and sTfR were positively associated with MDA levels.	Iron	10-12	paraoxonase 1	Homo sapiens	75-79
28240188-7	2017	Moreover, Fe levels were negatively associated with Hp and positively with PON1, total iron binding capacity and Tf, while ferritin and sTfR were positively associated with MDA levels.	Iron	10-12	transferrin	Homo sapiens	113-115
29081415-8	2017	The degree of altered iron accumulations was correlated to the amount of amyloid-beta plaques and tau pathology in the same block, as well as to Braak stage (p < 0.001).	Iron	22-26	amyloid beta precursor protein	Homo sapiens	73-85
28182038-15	2017	Raised hepcidin can predict the need for parenteral iron therapy and need for higher dose of recombinant human EPO to overcome iron-restricted erythropoiesis.	Iron	127-131	erythropoietin	Homo sapiens	111-114
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-65	iron-sulfur cluster assembly enzyme	Homo sapiens	154-158
28101313-10	2017	This oral chelation proved to be effective in clearing her hepatic iron overload after six months (LIC: 2 mg/g dry tissue), without side effects.	Iron	67-71	dynein cytoplasmic 1 light intermediate chain 2	Homo sapiens	99-105
27672211-8	2017	Furthermore, using a yeast shuffle strain, we demonstrated for the first time that each of the Cys Fe-S cluster ligands with the exception of C252 is essential, indicating that both Dre2 clusters are needed for cell viability.	Iron	99-103	electron carrier DRE2	Saccharomyces cerevisiae S288C	182-186
27317654-6	2017	Furthermore, elevated HO-1 increased inflammation, oxidative stress, matrix metalloproteinase-9/2 activity, and iron deposition.	Iron	112-116	heme oxygenase 1	Mus musculus	22-26
27721175-7	2017	These ENMLZ and IZ in the SSPN sample were richer in iron nitride (FeN) chromium nitride (CrN) along with the austenite phase.	Iron	67-70	sarcospan	Homo sapiens	26-30
27747853-8	2017	RESULTS: Cardiomyocytes exposed to gradually reduced iron concentrations in the medium demonstrated a decrease in the mRNA expression of FTH, FTL, FPN1, MB, and HAMP (all R = -0.75, p &lt; 0.05), indicating depleted iron status in the cells.	Iron	53-57	ferritin heavy chain 1	Rattus norvegicus	137-140
27747853-8	2017	RESULTS: Cardiomyocytes exposed to gradually reduced iron concentrations in the medium demonstrated a decrease in the mRNA expression of FTH, FTL, FPN1, MB, and HAMP (all R = -0.75, p &lt; 0.05), indicating depleted iron status in the cells.	Iron	53-57	ferritin light chain 1	Rattus norvegicus	142-145
27747853-8	2017	RESULTS: Cardiomyocytes exposed to gradually reduced iron concentrations in the medium demonstrated a decrease in the mRNA expression of FTH, FTL, FPN1, MB, and HAMP (all R = -0.75, p &lt; 0.05), indicating depleted iron status in the cells.	Iron	53-57	solute carrier family 40 member 1	Rattus norvegicus	147-151
27747853-8	2017	RESULTS: Cardiomyocytes exposed to gradually reduced iron concentrations in the medium demonstrated a decrease in the mRNA expression of FTH, FTL, FPN1, MB, and HAMP (all R = -0.75, p &lt; 0.05), indicating depleted iron status in the cells.	Iron	53-57	hepcidin antimicrobial peptide	Rattus norvegicus	161-165
28286378-3	2017	Firstly, we characterized the transcription of genes related to iron homeostasis in M1 RAW264.7 macrophages stimulated by IFN-gamma.	Iron	64-68	interferon gamma	Homo sapiens	122-131
28286378-6	2017	Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages.	Iron	0-4	interleukin 6	Homo sapiens	42-46
28286378-6	2017	Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages.	Iron	0-4	interleukin 1 beta	Homo sapiens	48-56
28286378-6	2017	Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages.	Iron	0-4	tumor necrosis factor	Homo sapiens	58-67
28286378-6	2017	Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages.	Iron	0-4	interferon gamma	Homo sapiens	90-99
29223935-4	2017	Serum ferritin and transferrin saturation were determined; criteria for Fe overload was serum ferritin &gt; 300 ng/ml and transferrin saturation = 50%.	Iron	72-74	transferrin	Homo sapiens	122-133
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	402-406	iron-sulfur cluster assembly enzyme	Homo sapiens	154-158
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	423-427	iron-sulfur cluster assembly enzyme	Homo sapiens	154-158
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-65	LYR motif containing 4	Homo sapiens	375-380
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-63	iron-sulfur cluster assembly enzyme	Homo sapiens	154-158
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-63	LYR motif containing 4	Homo sapiens	375-380
28203319-5	2017	Iron supplementation at rest increased iron concentration and transferrin saturation (p &lt; 0.01).	Iron	0-4	transferrin	Homo sapiens	62-73
28191272-1	2017	Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein which protects mitochondria from iron-induced oxidative damage.	Iron	49-53	ferritin mitochondrial	Mus musculus	24-28
28191272-1	2017	Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein which protects mitochondria from iron-induced oxidative damage.	Iron	103-107	ferritin mitochondrial	Mus musculus	24-28
27519319-1	2017	A Coke supported Fe3O4 and Fe0 composite (Fe0/Fe3O4/Coke) was prepared for the first time with the aim of evaluating its ability to be used as heterogeneous catalyst for the Fenton degradation of p-Nitrophenol (p-NP).	Iron	27-30	purine nucleoside phosphorylase	Homo sapiens	211-215
27576370-7	2017	Serum ferritin and non-transferrin-bound iron also decreased significantly.	Iron	41-45	transferrin	Homo sapiens	23-34
27519319-1	2017	A Coke supported Fe3O4 and Fe0 composite (Fe0/Fe3O4/Coke) was prepared for the first time with the aim of evaluating its ability to be used as heterogeneous catalyst for the Fenton degradation of p-Nitrophenol (p-NP).	Iron	42-45	purine nucleoside phosphorylase	Homo sapiens	211-215
27519319-6	2017	The recyclability of Fe0/Fe3O4/Coke was also investigated after three successive runs, in which p-NP degradation performances showed a slight difference with the first oxidation cycle with an acceptable iron leaching.	Iron	21-24	purine nucleoside phosphorylase	Homo sapiens	96-100
27696454-1	2017	BACKGROUND: Transfusion of a single unit of stored red blood cells (RBCs) has been hypothesized to induce supra-physiological levels of non-transferrin bound iron (NTBI), which may enhance inflammation and act as a nutrient for bacteria.	Iron	158-162	transferrin	Homo sapiens	140-151
27519319-6	2017	The recyclability of Fe0/Fe3O4/Coke was also investigated after three successive runs, in which p-NP degradation performances showed a slight difference with the first oxidation cycle with an acceptable iron leaching.	Iron	203-207	purine nucleoside phosphorylase	Homo sapiens	96-100
28042856-7	2016	Selective dietary supplementation with phenolics exhibiting pro-oxidant activity may increase the possibility of systemic oxidative stress in patients treated with medications containing chelating properties or those with high plasma concentrations of H2O2 and non-transferrin bound iron.	Iron	283-287	transferrin	Homo sapiens	265-276
28049896-8	2017	Furthermore, an iron-staining study demonstrated that the uptake of scFv-IONPs was notable only in HER2-positive tumors.	Iron	16-20	immunglobulin heavy chain variable region	Homo sapiens	68-72
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	ATP binding cassette subfamily B member 1	Homo sapiens	218-248
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	ATP binding cassette subfamily C member 1	Homo sapiens	250-254
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	ATP binding cassette subfamily C member 1	Homo sapiens	255-260
27866158-6	2016	MRP1 expression markedly increased upon macrophage activation, and the role of MRP1 in NO-induced 59Fe release was demonstrated by Mrp1 siRNA and the MRP1 inhibitor, MK571, which inhibited NO-mediated iron efflux.	Iron	201-205	ATP binding cassette subfamily C member 1	Homo sapiens	79-83
27866158-6	2016	MRP1 expression markedly increased upon macrophage activation, and the role of MRP1 in NO-induced 59Fe release was demonstrated by Mrp1 siRNA and the MRP1 inhibitor, MK571, which inhibited NO-mediated iron efflux.	Iron	201-205	ATP binding cassette subfamily C member 1	Homo sapiens	79-83
28100855-11	2016	An integral component of catalase (CAT) is iron ions.	Iron	43-47	catalase	Homo sapiens	25-33
28100855-11	2016	An integral component of catalase (CAT) is iron ions.	Iron	43-47	catalase	Homo sapiens	35-38
28006025-5	2016	Functional analysis indicated that in the light group, the down-regulated iron-sulfur cluster assembly protein (Iba57) would decrease the synthesis of protoporphyrin IX; furthermore, the up-regulated protein solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5) and down-regulated translocator protein (TSPO) would lead to increased amounts of protoporphyrin IX transported into the mitochondria matrix to form heme with iron, which is supplied by ovotransferrin protein (TF).	Iron	74-78	IBA57 homolog, iron-sulfur cluster assembly	Gallus gallus	112-117
27839948-1	2016	The widely conserved natural resistance-associated macrophage protein (Nramp) family of divalent metal transporters enables manganese import in bacteria and dietary iron uptake in mammals.	Iron	165-169	solute carrier family 11 member 1	Homo sapiens	21-69
28006025-5	2016	Functional analysis indicated that in the light group, the down-regulated iron-sulfur cluster assembly protein (Iba57) would decrease the synthesis of protoporphyrin IX; furthermore, the up-regulated protein solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5) and down-regulated translocator protein (TSPO) would lead to increased amounts of protoporphyrin IX transported into the mitochondria matrix to form heme with iron, which is supplied by ovotransferrin protein (TF).	Iron	469-473	IBA57 homolog, iron-sulfur cluster assembly	Gallus gallus	112-117
29083385-1	2016	Iron overload is increasingly being connected to insulin resistance in Type 2 Diabetes Mellitus (T2DM) patients.	Iron	0-4	insulin	Homo sapiens	49-56
27839948-1	2016	The widely conserved natural resistance-associated macrophage protein (Nramp) family of divalent metal transporters enables manganese import in bacteria and dietary iron uptake in mammals.	Iron	165-169	solute carrier family 11 member 1	Homo sapiens	71-76
28105341-7	2016	The excessive Fe levels in the bloodstream induced changes in serum ferritin and transferrin levels.	Iron	14-16	transferrin	Homo sapiens	81-92
27696504-8	2016	Total body and mitochondrial iron levels were significantly reduced by green tea supplementation in w1118 and mitoferrin mutants but not transferrin mutant flies.	Iron	29-33	mitoferrin	Drosophila melanogaster	110-120
27643674-1	2016	TMPRSS6 variants that affect protein function result in impaired matriptase-2 function and consequently uninhibited hepcidin production, leading to iron refractory iron deficiency anemia (IRIDA).	Iron	148-152	transmembrane serine protease 6	Homo sapiens	0-7
27643674-1	2016	TMPRSS6 variants that affect protein function result in impaired matriptase-2 function and consequently uninhibited hepcidin production, leading to iron refractory iron deficiency anemia (IRIDA).	Iron	148-152	transmembrane serine protease 6	Homo sapiens	65-77
27627839-1	2016	In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2+ into protoporphyrin IX.	Iron	57-61	transferrin	Homo sapiens	37-48
27627839-4	2016	In contrast, this study supports the hypothesis that the highly efficient transport of iron toward ferrochelatase in erythroid cells requires a direct interaction between transferrin-endosomes and mitochondria (the "kiss-and-run" hypothesis).	Iron	87-91	transferrin	Homo sapiens	171-182
27627839-11	2016	Altogether, our results suggest that a molecular mechanism exists to coordinate the iron status of endosomal transferrin with its trafficking.	Iron	84-88	transferrin	Homo sapiens	109-120
27439539-10	2016	In contrast, iron supplementation resulted in an increased production of IL-10 by adipose tissue and VAT macrophages.	Iron	13-17	interleukin 10	Mus musculus	73-78
27671803-3	2016	METHODS AND RESULTS: We designed and developed a chimeric construct encoding for both of iron-binding human ferritin heavy chain (hFTH) controlled by the beta-catenin-responsive TCF/lymphoid-enhancer binding factor (Lef) promoter and constitutively expressed green fluorescent protein (GFP).	Iron	89-93	hepatocyte nuclear factor 4 alpha	Homo sapiens	178-181
27671803-7	2016	The iron signal was absent when rats (n = 6) were chronically treated with SEN195 (10 mg/kg/day), a small-molecular inhibitor of beta-catenin/TCF-dependent gene transcription.	Iron	4-8	hepatocyte nuclear factor 4 alpha	Homo sapiens	142-145
27540134-0	2016	Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors.	Iron	56-60	Wnt family member 5A	Homo sapiens	0-5
27540134-13	2016	Thus, these data demonstrate that Wnt5a is critical for the pro-osteogenic effects of iron chelation using deferoxamine.	Iron	86-90	Wnt family member 5A	Homo sapiens	34-39
28053961-8	2016	However, both alcohol and iron significantly increased hepatic ferritin levels and decreased hepatic transferrin receptor levels (P &lt; 0.05).	Iron	26-30	transferrin	Rattus norvegicus	101-112
28491245-1	2016	BACKGROUND AND OBJECTIVES: Bacteria need iron for growth and most of them can actively acquire Fe ions using especial iron-chelating proteins which named siderophores.	Iron	95-97	outer membrane receptor FepA	Escherichia coli	41-45
28491245-1	2016	BACKGROUND AND OBJECTIVES: Bacteria need iron for growth and most of them can actively acquire Fe ions using especial iron-chelating proteins which named siderophores.	Iron	95-97	outer membrane receptor FepA	Escherichia coli	118-122
28491245-11	2016	Promoting or inhibitory effects of iron on bacterial growth mainly depend on the iron concentration in the culture medium however different siderophores have different potentials for capturing and assimilation of Fe ions by the bacteria, especially inside the host cell.	Iron	213-215	outer membrane receptor FepA	Escherichia coli	35-39
27211273-7	2016	We describe cryptic splicing events in the HSCs of SF3B1-mutant MDS, and our data support a model in which NMD-induced downregulation of the iron exporter ABCB7 mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 underlies the increased mitochondrial iron accumulation found in MDS patients with RS.	Iron	141-145	cripto, FRL-1, cryptic family 1	Homo sapiens	12-19
28043306-9	2016	Transferrin saturation was determined by dividing serum iron by TIBC and multiplying by 100.	Iron	56-60	transferrin	Homo sapiens	0-11
27253267-7	2016	Routine supplementation of Fe to these women resulted in persistent lower PON-1 activity in cord blood (P=0 02) and directionally lower (P=0 142) birth weights.	Iron	27-29	paraoxonase 1	Homo sapiens	74-79
27871472-9	2016	DISCUSSION: In the placenta of NH, increases in expressions of TFR1, transferrin, and ferritin of which those of TFR1 were especially marked, reflect increased iron influx from the mother to fetus.	Iron	160-164	transferrin	Homo sapiens	69-80
27253267-10	2016	CONCLUSIONS: Routine Fe supplementation in pregnant women with high Hb1 associated with increased oxidative stress, as reflected by low PON-1 activity in T1, could potentially lead to deleterious effects on birth weight.	Iron	21-23	histocompatibility minor HB-1	Homo sapiens	68-71
27253267-10	2016	CONCLUSIONS: Routine Fe supplementation in pregnant women with high Hb1 associated with increased oxidative stress, as reflected by low PON-1 activity in T1, could potentially lead to deleterious effects on birth weight.	Iron	21-23	paraoxonase 1	Homo sapiens	136-141
27764696-1	2016	Enhanced removal of As(V) and Se(VI) by zero valent iron (ZVI) has been recently revealed by using H2O2 as the corrosion accelerator, however, the detailed performance of such enhanced removal in ZVI column as well as the underlying mechanism is still unclear.	Iron	52-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	20-25
27694036-3	2016	With this approach, the ratio of orbital to spin magnetic moments for the Fe atoms in a single L10 ordered FePt nanoparticle is determined to be ml/ms=0.08+-0.02.	Iron	74-76	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	95-98
27764696-1	2016	Enhanced removal of As(V) and Se(VI) by zero valent iron (ZVI) has been recently revealed by using H2O2 as the corrosion accelerator, however, the detailed performance of such enhanced removal in ZVI column as well as the underlying mechanism is still unclear.	Iron	58-61	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	20-25
27713040-8	2016	An imbalance between endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) expression in response to iron overload was normalized by THU, L1 or the combination treatment.	Iron	113-117	nitric oxide synthase 2, inducible	Mus musculus	66-79
27728822-2	2016	The mechanism of attenuation was explained by comparison of X-ray absorption near edge structure (XANES) of As(V) co-precipitated with or adsorbed to iron (Fe) minerals in mine precipitates.	Iron	150-154	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	108-113
27728822-2	2016	The mechanism of attenuation was explained by comparison of X-ray absorption near edge structure (XANES) of As(V) co-precipitated with or adsorbed to iron (Fe) minerals in mine precipitates.	Iron	156-158	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	108-113
27713040-8	2016	An imbalance between endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) expression in response to iron overload was normalized by THU, L1 or the combination treatment.	Iron	113-117	nitric oxide synthase 2, inducible	Mus musculus	81-85
27764696-1	2016	Enhanced removal of As(V) and Se(VI) by zero valent iron (ZVI) has been recently revealed by using H2O2 as the corrosion accelerator, however, the detailed performance of such enhanced removal in ZVI column as well as the underlying mechanism is still unclear.	Iron	196-199	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	20-25
27764696-10	2016	In addition, the evolution of different oxidation states of As and Se retained in the column were identified by XPS, further demonstrating the comprehensive mechanisms of As(V)/Se(VI) removal involving reduction and adsorption in the ZVI/H2O2 column.	Iron	234-237	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	171-176
27901468-5	2016	In fh mutants, iron accumulation in the nervous system enhances the synthesis of sphingolipids, which in turn activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2) to trigger neurodegeneration of adult photoreceptors.	Iron	15-19	Phosphoinositide-dependent kinase 1	Drosophila melanogaster	167-171
27901468-6	2016	Here, we show that loss of Fxn in the nervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mechanism is evolutionarily conserved.	Iron	79-83	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	97-101
27901468-6	2016	Here, we show that loss of Fxn in the nervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mechanism is evolutionarily conserved.	Iron	79-83	myocyte enhancer factor 2C	Mus musculus	102-106
27906108-8	2016	Mechanistically, HO-1 degrades heme into biliverdin, releasing in the process ferrous iron and carbon monoxide (CO).	Iron	86-90	heme oxygenase 1	Mus musculus	17-21
27892483-1	2016	Mutations in Pantothenate kinase 2 and Coenzyme A (CoA) synthase (COASY), genes involved in CoA biosynthesis, are associated with rare neurodegenerative disorders with brain iron accumulation.	Iron	174-178	pantothenate kinase 2	Danio rerio	13-34
27892483-1	2016	Mutations in Pantothenate kinase 2 and Coenzyme A (CoA) synthase (COASY), genes involved in CoA biosynthesis, are associated with rare neurodegenerative disorders with brain iron accumulation.	Iron	174-178	CoA synthase	Danio rerio	39-64
27653419-6	2016	A bacterial Fe-S assembly complex, composed of the cysteine desulfurase IscS and scaffold protein IscU, was used to generate [2Fe-2S] clusters for transfer to mixtures of putative intermediate carrier and acceptor proteins.	Iron	12-16	iron-sulfur cluster assembly enzyme	Homo sapiens	98-102
27892483-1	2016	Mutations in Pantothenate kinase 2 and Coenzyme A (CoA) synthase (COASY), genes involved in CoA biosynthesis, are associated with rare neurodegenerative disorders with brain iron accumulation.	Iron	174-178	CoA synthase	Danio rerio	66-71
27853170-1	2016	Mitochondrial ferritin (FtMt) is a mitochondrially localized protein possessing ferroxidase activity and the ability to store iron.	Iron	126-130	ferritin mitochondrial	Mus musculus	24-28
27853170-6	2016	Concomitant to the above was a high "uncommitted" iron level found in the FtMt-/- group when exposed to acute exhaustion exercise.	Iron	50-54	ferritin mitochondrial	Mus musculus	74-78
27853170-2	2016	FtMt overexpression in cultured cells protects against oxidative damage by sequestering redox-active, intracellular iron.	Iron	116-120	ferritin mitochondrial	Mus musculus	0-4
27843711-11	2016	Iron contributed to the permeabilizatio of mitochondria, leading to the release of cytochrome C (cyto C), which, in turn, induced mitochondrial apoptosis in osteoblasts via activation of Caspase-3, up-regulation of Bax, and down-regulation of Bcl-2.	Iron	0-4	B cell leukemia/lymphoma 2	Mus musculus	243-248
27766842-3	2016	The chelation effect ensures the homodispersion of Fe in the polymer segments of the precursor, so that an effective catalytic conversion from sp3 to sp2 carbon occurs, enabling free rearrangement of graphene sheets into expanded nanographite and carbon micropores.	Iron	51-53	Sp3 transcription factor	Homo sapiens	143-146
27766842-3	2016	The chelation effect ensures the homodispersion of Fe in the polymer segments of the precursor, so that an effective catalytic conversion from sp3 to sp2 carbon occurs, enabling free rearrangement of graphene sheets into expanded nanographite and carbon micropores.	Iron	51-53	Sp2 transcription factor	Homo sapiens	150-153
29964685-2	2016	The zero-valent iron dosage was 71 g L-1.	Iron	16-20	immunoglobulin kappa variable 1-16	Homo sapiens	37-40
31457166-1	2016	Pirin is an iron (Fe)-dependent regulatory protein of nuclear factor kappaB (NF-kappaB) transcription factors.	Iron	12-16	pirin	Homo sapiens	0-5
31457166-1	2016	Pirin is an iron (Fe)-dependent regulatory protein of nuclear factor kappaB (NF-kappaB) transcription factors.	Iron	12-16	nuclear factor kappa B subunit 1	Homo sapiens	77-86
31457166-1	2016	Pirin is an iron (Fe)-dependent regulatory protein of nuclear factor kappaB (NF-kappaB) transcription factors.	Iron	18-20	pirin	Homo sapiens	0-5
31457166-1	2016	Pirin is an iron (Fe)-dependent regulatory protein of nuclear factor kappaB (NF-kappaB) transcription factors.	Iron	18-20	nuclear factor kappa B subunit 1	Homo sapiens	77-86
31457166-2	2016	Binding studies have suggested that the oxidative state of iron plays a crucial role in modulating the binding of Pirin to NF-kappaB p65, in turn enhancing the binding of p65 to DNA.	Iron	59-63	pirin	Homo sapiens	114-119
27681840-1	2016	Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome.	Iron	53-57	transferrin	Homo sapiens	150-161
27681840-1	2016	Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome.	Iron	133-137	transferrin	Homo sapiens	150-161
27709206-0	2016	Iron-catalyzed oxidative sp3 carbon-hydrogen bond functionalization of 3,4-dihydro-1,4-benzoxazin-2-ones.	Iron	0-4	Sp3 transcription factor	Homo sapiens	25-28
27709206-1	2016	A novel and efficient iron-catalyzed sp3 carbon-hydrogen bond functionalization of benzoxazinone derivatives has been developed.	Iron	22-26	Sp3 transcription factor	Homo sapiens	37-40
27779854-5	2016	Even under nonaqueous conditions, both oxygen and illumination together show slow oxidation of iron over the course of a few hours, consistent with forming an Fe3+-O2- intermediate as corroborated by resonance-enhanced Raman spectroscopy, with a rate constant of k = 3.03(8) x 10-3 min-1.	Iron	95-99	CD59 molecule (CD59 blood group)	Homo sapiens	282-287
27581396-2	2016	Herein, we report that covalent anchoring of human transferrin to carbon-coated iron magnetic nanoparticles functionalized with carboxylic groups (Fe@C-COOH Nps) in the presence of magnetic field results in its conformational integrity and electroactivity.	Iron	147-149	transferrin	Homo sapiens	51-62
27581396-3	2016	We have found that, the direct contact of human transferrin with Fe@C-COOH Nps does not lead to release of iron and in consequence to the irreversible conformational changes of the protein.	Iron	65-67	transferrin	Homo sapiens	48-59
27581396-0	2016	Conformational control of human transferrin covalently anchored to carbon-coated iron nanoparticles in presence of a magnetic field.	Iron	81-85	transferrin	Homo sapiens	32-43
27581396-3	2016	We have found that, the direct contact of human transferrin with Fe@C-COOH Nps does not lead to release of iron and in consequence to the irreversible conformational changes of the protein.	Iron	107-111	transferrin	Homo sapiens	48-59
27581396-2	2016	Herein, we report that covalent anchoring of human transferrin to carbon-coated iron magnetic nanoparticles functionalized with carboxylic groups (Fe@C-COOH Nps) in the presence of magnetic field results in its conformational integrity and electroactivity.	Iron	80-84	transferrin	Homo sapiens	51-62
27581396-7	2016	We showed that it is possible to attach, without changing pH, more than one single layer of transferrin to the Fe@C-COOH Nps.	Iron	111-113	transferrin	Homo sapiens	92-103
27507623-0	2016	Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.	Iron	112-116	haptoglobin	Homo sapiens	45-56
27534995-3	2016	Catalytic iron, also known as labile iron, is a transitional pool of non-transferrin-bound iron that is readily available to participate in redox cycling.	Iron	10-14	transferrin	Homo sapiens	73-84
27534995-3	2016	Catalytic iron, also known as labile iron, is a transitional pool of non-transferrin-bound iron that is readily available to participate in redox cycling.	Iron	37-41	transferrin	Homo sapiens	73-84
27534995-3	2016	Catalytic iron, also known as labile iron, is a transitional pool of non-transferrin-bound iron that is readily available to participate in redox cycling.	Iron	37-41	transferrin	Homo sapiens	73-84
27552044-3	2016	In this study, we examine the effect of PO43- on sorption of arsenate (As(V)) and arsenite (As(III)) to nanoparticulate FeS at pH 6, 7 and 9.	Iron	120-123	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	71-76
27552044-10	2016	This study shows that nanoparticulate FeS can help to immobilize As(III) and As(V) in sulfidic subsurface environments where As co-exists with PO43-.	Iron	38-41	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	77-82
27523281-0	2016	EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1.	Iron	15-19	epidermal growth factor receptor	Homo sapiens	0-4
27507872-0	2016	Critical Role of Iron in Epoetin Alfa Treatment of Chemotherapy-Associated Anemia.	Iron	17-21	erythropoietin	Homo sapiens	25-32
27592288-4	2016	When blood concentrations of glucose are high (as in a diabetic subject), transferrin can be glycated, modifying its ability to bind and transport iron.	Iron	147-151	transferrin	Rattus norvegicus	74-85
27647307-6	2016	ApoE also has Abeta-independent pathways in AD, which has led to the discovery of new roles of ApoE ranging from mitochondria dysfunction to, most recently, iron metabolism.	Iron	157-161	apolipoprotein E	Homo sapiens	0-4
27647307-6	2016	ApoE also has Abeta-independent pathways in AD, which has led to the discovery of new roles of ApoE ranging from mitochondria dysfunction to, most recently, iron metabolism.	Iron	157-161	apolipoprotein E	Homo sapiens	95-99
27893677-6	2016	There was significantly positive correlation between serum iron and IL-6 serum level.We concluded that humoral, nonspecific immunity (phagocytic activity and oxidative burst), and the IL-6 are influenced in patients with iron deficiency anemia.	Iron	59-63	interleukin 6	Homo sapiens	184-188
27620552-7	2016	Iron transferrin saturation and serum ferritin levels were lower in the CKD patients.	Iron	0-4	transferrin	Homo sapiens	5-16
27344508-0	2016	Clinical and methodological factors affecting non-transferrin-bound iron values using a novel fluorescent bead assay.	Iron	68-72	transferrin	Homo sapiens	50-61
27344508-1	2016	Nontransferrin-bound iron (NTBI) is a heterogeneously speciated plasma iron, typically detectable when transferrin saturation (TfSat) exceeds 75%.	Iron	21-25	transferrin	Homo sapiens	3-14
27344508-1	2016	Nontransferrin-bound iron (NTBI) is a heterogeneously speciated plasma iron, typically detectable when transferrin saturation (TfSat) exceeds 75%.	Iron	71-75	transferrin	Homo sapiens	3-14
29786178-4	2016	The retrieved bioaccumulation factor (BAF) indicated that N. Stolatus has high potential to be a biomonitor for the contaminations of Fe and Mn in water and Cd, Ni and Pb in sediment.	Iron	134-136	BAF nuclear assembly factor 1	Homo sapiens	38-41
26558634-5	2016	Here, we examined the effects of iron exposure in the neonatal period (12th-14th day of postnatal life) on the expression of proteasome beta-1, beta-2, and beta-5 subunits, and ubiquitinated proteins in brains of 15-day-old rats, to evaluate the immediate effect of the treatment, and in adulthood to assess long-lasting effects.	Iron	33-37	adaptor related protein complex 5 subunit beta 1	Rattus norvegicus	156-162
27660166-0	2016	Ubiquitination-Related MdBT Scaffold Proteins Target a bHLH Transcription Factor for Iron Homeostasis.	Iron	85-89	basic helix-loop-helix protein A	Malus domestica	55-80
27523281-4	2016	Here we report that epidermal growth factor receptor (EGFR), an oncogenic driver, binds to and regulates the subcellular distribution of transferrin receptor 1(TfR1) through its tyrosine kinase activity and thus is required for cellular iron import.	Iron	237-241	epidermal growth factor receptor	Homo sapiens	20-52
27872738-4	2016	The exact mechanisms responsible for progression from norm glycaemia to overt diabetes in these patients are still poorly understood but are attributed mainly to insulin deficiency resulting from the toxic effects of iron deposited in the pancreas and insulin resistance.	Iron	217-221	insulin	Homo sapiens	162-169
27523281-4	2016	Here we report that epidermal growth factor receptor (EGFR), an oncogenic driver, binds to and regulates the subcellular distribution of transferrin receptor 1(TfR1) through its tyrosine kinase activity and thus is required for cellular iron import.	Iron	237-241	epidermal growth factor receptor	Homo sapiens	54-58
27523281-5	2016	Inactivation of EGFR reduces the cell surface TfR1 expression, which leads to decreased iron import due to impaired TfR1-mediated iron uptake.	Iron	88-92	epidermal growth factor receptor	Homo sapiens	16-20
27523281-5	2016	Inactivation of EGFR reduces the cell surface TfR1 expression, which leads to decreased iron import due to impaired TfR1-mediated iron uptake.	Iron	130-134	epidermal growth factor receptor	Homo sapiens	16-20
27523281-8	2016	Our findings uncover a new role of EGFR in modulating cellular iron homeostasis through redistribution of TfR1, which is essential for cancer development and progression.	Iron	63-67	epidermal growth factor receptor	Homo sapiens	35-39
27519415-9	2016	Instead, Glrx3 and BolA2 bound and facilitated Fe-S incorporation into Ciapin1, a [2Fe-2S] protein functioning early in the cytosolic Fe-S assembly pathway.	Iron	47-51	cytokine induced apoptosis inhibitor 1	Homo sapiens	71-78
27783661-1	2016	Hereditary myopathy with lactic acidosis (HML) is an autosomal recessive disease caused by an intronic one-base mutation in the iron-sulfur cluster assembly (ISCU) gene, resulting in aberrant splicing.	Iron	128-132	iron-sulfur cluster assembly enzyme	Homo sapiens	158-162
27783661-2	2016	The incorrectly spliced transcripts contain a 100 or 86 bp intron sequence encoding a non-functional ISCU protein, which leads to defects in several Fe-S containing proteins in the respiratory chain and the TCA cycle.	Iron	149-153	iron-sulfur cluster assembly enzyme	Homo sapiens	101-105
27792144-7	2016	In addition, the expression of some Fe acquisition-related genes, including FIT1, FRO2, and IRT1 were significantly up-regulated by melatonin treatments, whereas the enhanced expression of these genes was obviously suppressed in the polyamine- and NO-deficient plants.	Iron	36-38	FER-like regulator of iron uptake	Arabidopsis thaliana	76-80
27776180-0	2016	Investigating the Interaction of Fe Nanoparticles with Lysozyme by Biophysical and Molecular Docking Studies.	Iron	33-35	lysozyme	Homo sapiens	55-63
27776180-1	2016	Herein, the interaction of hen egg white lysozyme (HEWL) with iron nanoparticle (Fe NP) was investigated by spectroscopic and docking studies.	Iron	62-66	lysozyme	Homo sapiens	41-49
27519415-9	2016	Instead, Glrx3 and BolA2 bound and facilitated Fe-S incorporation into Ciapin1, a [2Fe-2S] protein functioning early in the cytosolic Fe-S assembly pathway.	Iron	134-138	cytokine induced apoptosis inhibitor 1	Homo sapiens	71-78
27741250-4	2016	We report that rapid xylose conversion by engineered and evolved S. cerevisiae strains depends upon epistatic interactions among genes encoding a xylose reductase (GRE3), a component of MAP Kinase (MAPK) signaling (HOG1), a regulator of Protein Kinase A (PKA) signaling (IRA2), and a scaffolding protein for mitochondrial iron-sulfur (Fe-S) cluster biogenesis (ISU1).	Iron	335-339	trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))	Saccharomyces cerevisiae S288C	164-168
27394636-6	2016	The bioaccumulation factor (BAF) of Fe was highest followed by Zn and the lowest value was observed with Ni.	Iron	36-38	BAF nuclear assembly factor 1	Homo sapiens	28-31
27741250-4	2016	We report that rapid xylose conversion by engineered and evolved S. cerevisiae strains depends upon epistatic interactions among genes encoding a xylose reductase (GRE3), a component of MAP Kinase (MAPK) signaling (HOG1), a regulator of Protein Kinase A (PKA) signaling (IRA2), and a scaffolding protein for mitochondrial iron-sulfur (Fe-S) cluster biogenesis (ISU1).	Iron	335-339	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	215-219
27801326-4	2016	Iron overload was observed in 52(55.32%)of 94 MDS patients, in which a higher prevalence of iron overload was observed in low risk groups(IPSS low/Int-1 risk groups)than higher risk groups(Int-2/high risk groups).	Iron	0-4	Wnt family member 1	Homo sapiens	147-152
27639148-1	2016	The present work reports the application of a new molybdenum disulphide (MoS2)-based electrochemical platform for highly sensitive quantitation of an iron-binding protein, bovine serum albumin (BSA).	Iron	150-154	albumin	Homo sapiens	179-192
27855097-3	2016	Prior studies have demonstrated that intravenous iron might synergistically improve therapeutic response to EPO treatment in this patient population.	Iron	49-53	erythropoietin	Homo sapiens	108-111
27576776-0	2016	Toll-Like Receptor 4/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage.	Iron	83-87	toll-like receptor 4	Mus musculus	0-20
27531515-6	2016	A disruption mutant in the adenylation domain of AmoG was unable to synthesize any amonabactin and to grow in iron stress conditions while a deletion of amoH resulted in the production of only two over the four forms.	Iron	110-114	ATPase Na+/K+ transporting subunit beta 2	Homo sapiens	49-53
27576776-10	2016	TLR4-/- and MyD88-/- mice exhibited improvement in brain iron efflux at 7, 14, and 28 days after ICH, and the TLR4 antagonist (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate significantly decreased brain iron levels at days 14 and 28 after ICH and improved cognition impairment at day 28.	Iron	57-61	toll-like receptor 4	Mus musculus	0-4
27589831-8	2016	FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron.	Iron	32-36	transferrin	Homo sapiens	89-100
27589831-8	2016	FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron.	Iron	32-36	transferrin	Homo sapiens	129-140
27589831-8	2016	FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron.	Iron	147-151	transferrin	Homo sapiens	89-100
27589831-8	2016	FAC is a cell-permeable form of iron, which can passively enter into cells bypassing the transferrin receptor mediated uptake of transferrin-bound iron.	Iron	147-151	transferrin	Homo sapiens	129-140
27311688-1	2016	AIMS: Recent biological and epidemiological studies have found that insulin resistance is linked to iron overload.	Iron	100-104	insulin	Homo sapiens	68-75
27311688-3	2016	In this gender-separated cross-sectional study, we aimed to investigate the association of hemoglobin and serum iron levels with early-phase insulin secretion in non-diabetic subjects.	Iron	112-116	insulin	Homo sapiens	141-148
27748454-4	2016	APOE-e4 and MCI was also associated with higher cortical iron.	Iron	57-61	apolipoprotein E	Homo sapiens	0-7
27748454-5	2016	Moreover, cerebral iron significantly affected functional coupling, and was furthermore associated with increased Abeta-plaque-load (R2-adjusted = 0.80, p &lt; 0.001) and APOE-e4 carrier status (p &lt; 0.001) in MCI.	Iron	19-23	apolipoprotein E	Homo sapiens	171-178
27530256-8	2016	Some selenium (Se) compounds e.g. selenoprotein P also appear to protect APP against excessive copper and iron deposition.	Iron	106-110	selenoprotein P	Homo sapiens	34-49
26643377-11	2016	It is possible that an imbalance in iron homeostasis and the dopaminergic system may represent a link between RLS incidence and migraines.	Iron	36-40	RLS1	Homo sapiens	110-113
26866925-2	2016	Heme oxygenase 1 (HO-1, hmox) is the first and rate limiting enzyme in the breakdown of heme originating from degraded senescent erythrocytes and heme-proteins, yielding equal amounts of iron, carbon monoxide and biliverdin.	Iron	187-191	heme oxygenase 1	Mus musculus	18-22
27259564-0	2016	Cerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS.	Iron	16-20	fragile X messenger ribonucleoprotein 1	Homo sapiens	49-53
26866925-8	2016	Mechanistically, these latter effects result from intracellular iron limitation with subsequent activation of NF-kappaB and further inos, tnfa and p47phox transcription along with reduced formation of the anti-inflammatory and radical scavenging molecules, CO and biliverdin as a consequence of HO-1 silencing.	Iron	64-68	heme oxygenase 1	Mus musculus	295-299
26866925-2	2016	Heme oxygenase 1 (HO-1, hmox) is the first and rate limiting enzyme in the breakdown of heme originating from degraded senescent erythrocytes and heme-proteins, yielding equal amounts of iron, carbon monoxide and biliverdin.	Iron	187-191	heme oxygenase 1	Mus musculus	24-28
26620679-5	2016	The anions in the area varied in the order HCO3 (-) &gt; Cl(-) &gt; SO4 (2-) &gt; NO3 (-) and cations varied in the order Ca(2+) &gt; Mg(2+) &gt; Na(+) &gt; K(+) &gt; Fe(2+).	Iron	167-169	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
27692637-4	2016	IMPLICATIONS: This agent may be administered to patients with stage 5 chronic kidney disease receiving hemodialysis as a new iron supplementation option to maintain hemoglobin, transferrin saturation, and ferritin concentrations.	Iron	125-129	transferrin	Homo sapiens	177-188
27682263-8	2016	A new therapeutic concept with conservative iron chelation rescues iron-overloaded neurons by scavenging labile iron and, by delivering this chelated metal to endogenous apo-transferrin, allows iron redistribution to avoid systemic loss of iron.	Iron	44-48	transferrin	Homo sapiens	174-185
27403535-7	2016	However, under the condition of reduced heme biosynthesis with reduced iron reutilization and increased storage iron, hepcidin at the lower and higher range of normal showed a striking role in tissue distribution of iron.	Iron	112-116	hepcidin antimicrobial peptide	Rattus norvegicus	118-126
27664951-1	2016	OBJECTIVES: Transferrin is a glycosylated protein responsible for transporting iron, an essential metal responsible for proper fetal development.	Iron	79-83	transferrin	Homo sapiens	12-23
27403535-7	2016	However, under the condition of reduced heme biosynthesis with reduced iron reutilization and increased storage iron, hepcidin at the lower and higher range of normal showed a striking role in tissue distribution of iron.	Iron	112-116	hepcidin antimicrobial peptide	Rattus norvegicus	118-126
27040361-10	2016	Accordingly, the ferroxidase activities simultaneously decreased, whereas the protein levels of Ft and Fpn1 significantly increased, indicating further iron accumulation.	Iron	152-156	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	103-107
26666988-0	2016	Iron and carbon monoxide prevent degradation of plasmatic coagulation by thrombin-like activity in rattlesnake venom.	Iron	0-4	coagulation factor II, thrombin	Homo sapiens	73-81
26666988-4	2016	Thus, the present investigation sought to determine if pretreatment of plasma with Fe and CO could attenuate venom-mediated catalysis of fibrinogen via thrombin-like activity.	Iron	83-85	coagulation factor II, thrombin	Homo sapiens	152-160
27590019-1	2016	Glutathione-coordinated [2Fe-2S] complex is a non-protein-bound [2Fe-2S] cluster that is capable of reconstituting the human iron-sulfur cluster scaffold protein IscU.	Iron	125-129	iron-sulfur cluster assembly enzyme	Homo sapiens	162-166
27398985-2	2016	Hepcidin plays a key role in iron homeostasis and is regulated by anemia and inflammation.	Iron	29-33	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
27891416-10	2016	Total Iron Binding Capacity (TIBC) on the other hand, had a strong, highly significant (p&lt;0.001) negative correlation with SOD, CAT, and GPx but a strong, highly significant positive correlation (p&lt;0.001) with MDA.	Iron	6-10	catalase	Homo sapiens	131-134
27891416-11	2016	After eight weeks of daily iron therapy, a highly significant rise (p&lt;0.001) from baseline was observed in levels of SOD, CAT, and GPx in subjects with IDA.	Iron	27-31	catalase	Homo sapiens	125-128
26992200-10	2016	CONCLUSION: Preterm infants can control iron levels by regulating hepcidin and decreasing erythropoietin.	Iron	40-44	erythropoietin	Homo sapiens	90-104
27107558-5	2016	An ~10-fold increase in ceruloplasmin and ~4-fold increase in haptoglobin gene expression suggested a possible association between vitamin D and iron homeostasis.	Iron	145-149	haptoglobin	Homo sapiens	62-73
27459537-9	2016	NAF-1 repression in INS-1 cells decreased insulin content and glucose-stimulated insulin secretion, while maintaining the response to cAMP, and enhanced the accumulation of labile iron and reactive oxygen species in mitochondria.	Iron	180-184	nuclear assembly factor 1 ribonucleoprotein	Rattus norvegicus	0-5
26385576-3	2016	Heme oxygenase isoform 1 (HO-1) is crucial for the response to oxidative stress via the catabolism of heme to carbon monoxide, bilirubin, and iron.	Iron	142-146	heme oxygenase 1	Mus musculus	0-24
27714045-2	2016	In most organisms, Fe-S clusters are initially assembled on a scaffold protein, ISCU, and subsequently transferred to target proteins or to intermediate carriers by a dedicated chaperone/co-chaperone system.	Iron	19-23	iron-sulfur cluster assembly enzyme	Homo sapiens	80-84
27714045-3	2016	The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins, and, in mammals, it relies on the activity of a multiprotein transfer complex that contains the chaperone HSPA9, the co-chaperone HSC20 and the scaffold ISCU.	Iron	26-30	heat shock protein family A (Hsp70) member 9	Homo sapiens	222-227
27714045-3	2016	The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins, and, in mammals, it relies on the activity of a multiprotein transfer complex that contains the chaperone HSPA9, the co-chaperone HSC20 and the scaffold ISCU.	Iron	26-30	iron-sulfur cluster assembly enzyme	Homo sapiens	269-273
27714045-3	2016	The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins, and, in mammals, it relies on the activity of a multiprotein transfer complex that contains the chaperone HSPA9, the co-chaperone HSC20 and the scaffold ISCU.	Iron	101-105	heat shock protein family A (Hsp70) member 9	Homo sapiens	222-227
27714045-3	2016	The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins, and, in mammals, it relies on the activity of a multiprotein transfer complex that contains the chaperone HSPA9, the co-chaperone HSC20 and the scaffold ISCU.	Iron	101-105	iron-sulfur cluster assembly enzyme	Homo sapiens	269-273
26998752-4	2016	RESULTS: Dysmetabolic iron overload syndrome patients had higher peak transferrin saturation and area under the-curve of transferrin saturation than subjects with normal iron status, but lower values than haemochromatosis patients (P &lt; 0.05 for all).	Iron	22-26	transferrin	Homo sapiens	70-81
26998752-4	2016	RESULTS: Dysmetabolic iron overload syndrome patients had higher peak transferrin saturation and area under the-curve of transferrin saturation than subjects with normal iron status, but lower values than haemochromatosis patients (P &lt; 0.05 for all).	Iron	22-26	transferrin	Homo sapiens	121-132
27107905-1	2016	FANCJ is a superfamily 2 DNA helicase, which also belongs to the iron-sulfur domain containing helicases that include XPD, ChlR1 (DDX11), and RTEL1.	Iron	65-69	DEAD/H-box helicase 11	Homo sapiens	123-128
27107905-1	2016	FANCJ is a superfamily 2 DNA helicase, which also belongs to the iron-sulfur domain containing helicases that include XPD, ChlR1 (DDX11), and RTEL1.	Iron	65-69	DEAD/H-box helicase 11	Homo sapiens	130-135
26385576-3	2016	Heme oxygenase isoform 1 (HO-1) is crucial for the response to oxidative stress via the catabolism of heme to carbon monoxide, bilirubin, and iron.	Iron	142-146	heme oxygenase 1	Mus musculus	26-30
27353397-0	2016	The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions.	Iron	125-129	transferrin	Homo sapiens	37-48
27353397-0	2016	The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions.	Iron	142-146	transferrin	Homo sapiens	37-48
27519411-8	2016	Binding of 12 [NFS1]2 [ISD11]2 sub-complexes to the surface results in a globular macromolecule with a diameter of ~15 nm and creates 24 Fe-S cluster assembly centers.	Iron	137-141	LYR motif containing 4	Homo sapiens	23-28
27353397-1	2016	Neisseria gonorrhoeae produces two transferrin binding proteins, TbpA and TbpB, which together enable efficient iron transport from human transferrin.	Iron	112-116	transferrin	Homo sapiens	35-46
27353397-1	2016	Neisseria gonorrhoeae produces two transferrin binding proteins, TbpA and TbpB, which together enable efficient iron transport from human transferrin.	Iron	112-116	transferrin	Homo sapiens	138-149
27353397-4	2016	The misR mutant was capable of transferrin-iron uptake at only 50% of wild-type levels, consistent with decreased tbp expression.	Iron	43-47	transferrin	Homo sapiens	31-42
27503603-0	2016	Glutaredoxin GRXS17 Associates with the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Iron	50-54	CAX-interacting protein 2	Arabidopsis thaliana	0-12
27503603-5	2016	We also found that several putative Fe-S client proteins directly bind to GRXS17, such as XANTHINE DEHYDROGENASE1 (XDH1), involved in the purine salvage pathway, and CYTOSOLIC THIOURIDYLASE SUBUNIT1 and CYTOSOLIC THIOURIDYLASE SUBUNIT2, both essential for the 2-thiolation step of 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification of tRNAs.	Iron	36-40	xanthine dehydrogenase 1	Arabidopsis thaliana	90-113
27503603-5	2016	We also found that several putative Fe-S client proteins directly bind to GRXS17, such as XANTHINE DEHYDROGENASE1 (XDH1), involved in the purine salvage pathway, and CYTOSOLIC THIOURIDYLASE SUBUNIT1 and CYTOSOLIC THIOURIDYLASE SUBUNIT2, both essential for the 2-thiolation step of 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification of tRNAs.	Iron	36-40	xanthine dehydrogenase 1	Arabidopsis thaliana	115-119
27567687-10	2016	The endothelial cells demonstrated an up-regulation of transferrin receptor mRNA after treatment with the iron chelator deferoxamine.	Iron	106-110	serotransferrin	Bos taurus	55-66
29924571-4	2016	In this review, we focused on the studies in the latest five years on the mechanisms of NLRP3 inflammasome regulation which mainly including NLRP3 priming, three protein complex assembly and regulation of NLRP3 inflammasome activation by endogenous metabolic compounds, iron flux, subcellular structure, other types of cells and small molecular compounds.	Iron	270-274	NLR family pyrin domain containing 3	Homo sapiens	88-93
27519411-9	2016	The organization of each center recapitulates a previously proposed conserved mechanism for sulfur donation from NFS1 to ISCU and reveals, for the first time, a path for iron donation from FXN42-210 to ISCU.	Iron	170-174	iron-sulfur cluster assembly enzyme	Homo sapiens	202-206
27546461-0	2016	Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.	Iron	0-4	signal transducer and activator of transcription 3	Mus musculus	52-57
27646275-0	2016	Endosome-mitochondria interactions are modulated by iron release from transferrin.	Iron	52-56	transferrin	Homo sapiens	70-81
27646275-1	2016	Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells.	Iron	67-71	transferrin	Homo sapiens	78-89
27646275-1	2016	Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells.	Iron	67-71	transferrin	Homo sapiens	91-93
27646275-1	2016	Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells.	Iron	149-153	transferrin	Homo sapiens	78-89
27646275-1	2016	Transient "kiss and run" interactions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells.	Iron	149-153	transferrin	Homo sapiens	91-93
27646275-4	2016	Quenching of iron sensor RDA-labeled mitochondria confirmed functional iron transfer by an interacting Tf-endosome.	Iron	13-17	transferrin	Homo sapiens	103-105
27646275-4	2016	Quenching of iron sensor RDA-labeled mitochondria confirmed functional iron transfer by an interacting Tf-endosome.	Iron	71-75	transferrin	Homo sapiens	103-105
27646275-6	2016	To further assess the functional role of iron in the ability of Tf-endosomes to interact with mitochondria, we blocked endosomal iron release by using a Tf K206E/K534A mutant.	Iron	41-45	transferrin	Homo sapiens	64-66
27646275-7	2016	Blocking intraendosomal iron release led to significantly increased motility of Tf-endosomes and increased duration of endosome-mitochondria interactions.	Iron	24-28	transferrin	Homo sapiens	80-82
27646275-8	2016	Thus, intraendosomal iron regulates the kinetics of the interactions between Tf-containing endosomes and mitochondria in epithelial cells.	Iron	21-25	transferrin	Homo sapiens	77-79
27445333-7	2016	Moreover, ribosomal inactivation-induced iron accumulation in Caenorhabditis elegans as a simplified in vivo model for gut nutrition uptake was dependent on SEK-1, a p38 kinase activator, leading to suppression of FPN-1.1 expression and iron accumulation.	Iron	41-45	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	157-162
27445333-7	2016	Moreover, ribosomal inactivation-induced iron accumulation in Caenorhabditis elegans as a simplified in vivo model for gut nutrition uptake was dependent on SEK-1, a p38 kinase activator, leading to suppression of FPN-1.1 expression and iron accumulation.	Iron	41-45	mitogen-activated protein kinase 14	Homo sapiens	166-169
27445333-7	2016	Moreover, ribosomal inactivation-induced iron accumulation in Caenorhabditis elegans as a simplified in vivo model for gut nutrition uptake was dependent on SEK-1, a p38 kinase activator, leading to suppression of FPN-1.1 expression and iron accumulation.	Iron	237-241	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	157-162
27449336-1	2016	UNLABELLED: Iron chelators are known activators of the Hypoxia Includible Factor-1alpha (HIF-1alpha) pathway, a critical cellular pathway involved in angiogenic responses to hypoxia.	Iron	12-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
27449336-4	2016	In vitro, low doses of the iron chelator Deferoxamine (DFO) has shown to induce HIF-1alpha mediated osteoclast formation and function.	Iron	27-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
27607732-3	2016	[SiP(iPr) 3 ]Fe(CN) additionally serves as a useful entry point to rare examples of terminally-bound Fe(CNH) and Fe(CNH2 ) species that, in accord with preliminary mechanistic studies, are plausible intermediates of the cyanide reductive protonation to generate CH4 and NH3 .	Iron	13-16	tumor protein p53 inducible nuclear protein 1	Homo sapiens	1-11
27571509-0	2016	Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1.	Iron	62-66	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	184-204
27546461-4	2016	Proteomic and genomic analyses identified an iron-regulated signaling axis mediated by cyclin-dependent kinase 1 (CDK1), JAK1, and STAT3 in CRC progression.	Iron	45-49	signal transducer and activator of transcription 3	Mus musculus	131-136
27573840-1	2016	Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese.	Iron	138-142	solute carrier family 11 member 1	Homo sapiens	0-48
27170684-12	2016	Surprisingly, rA1M exerted select injury-promoting effects (increased in vitro catalytic iron/antimycin toxicities and increased in vivo monocyte chemoattractant protein-1/neutrophil gelatinase-associated lipocalin mRNA expression after glycerol or endotoxin injection).	Iron	89-93	pregnancy-zone protein	Rattus norvegicus	14-18
27573840-1	2016	Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese.	Iron	138-142	solute carrier family 11 member 1	Homo sapiens	50-55
27618952-2	2016	We show that yeast cells lacking Aft2, a transcription factor that together with Aft1 regulates iron homeostasis, are highly sensitive to selenite but, in contrast to aft1 mutants, this is not rescued by iron supplementation.	Iron	96-100	Aft2p	Saccharomyces cerevisiae S288C	33-37
26785641-7	2016	Low concentrations of iron and hemoglobin in maternal serum coexisting with high level of erythropoietin suggest that smoking could lead to subclinical iron deficiency and chronic hypoxia not only in mothers but also in fetus.	Iron	152-156	erythropoietin	Homo sapiens	90-104
27390324-4	2016	Ablation of NHE3 strongly depleted liver iron stores, regardless of diet.	Iron	41-45	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	12-16
27390324-6	2016	Intestinal expression of DMT1, the apical surface ferrireductase cytochrome b reductase-1, and the basolateral iron exporter ferroportin was upregulated in NHE3(-/-) mice, and expression of liver Hamp1 (hepcidin) was suppressed compared with wild-type mice.	Iron	111-115	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	156-160
27390324-7	2016	Absorption of (59)Fe from an oral dose was substantially impaired in NHE3(-/-) compared with wild-type mice.	Iron	18-20	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	69-73
27390324-8	2016	Our data point to an important role for NHE3 in generating the H(+) gradient that drives DMT1-mediated iron uptake at the intestinal brush border.	Iron	103-107	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	40-44
27374715-8	2016	The analysis of serum iron status according to feeding methods during the first six months revealed higher iron, ferritin, and transferrin saturation levels in children exclusively or mainly fed formula than in children exclusively or mainly fed breast milk.	Iron	22-26	transferrin	Homo sapiens	127-138
27320438-4	2016	The catalytic reactions between 2,2",4,4",5,5"-hexachlorobiphenyl (PCB-153) and AC-supported Fe, Ni, Cu and Zn catalysts were conducted under N2 atmosphere.	Iron	93-95	pyruvate carboxylase	Homo sapiens	67-70
27287253-8	2016	Iron dose-dependently attenuated ECM mineralization and decreased the expressions of Runx2 and OCN.	Iron	0-4	RUNX family transcription factor 2	Homo sapiens	85-90
27287253-8	2016	Iron dose-dependently attenuated ECM mineralization and decreased the expressions of Runx2 and OCN.	Iron	0-4	bone gamma-carboxyglutamate protein	Homo sapiens	95-98
27300774-2	2016	The results showed that the differential absorbance spectra (DAS) provided discernible features for revealing the changes in optical properties of EPSs induced by metals, i.e., the intensity of DAS increased largely with incrementally increased metal concentrations (Fe(III), Cu(II), and Pb(II)).	Iron	267-269	submaxillary gland androgen regulated protein 3B	Homo sapiens	288-295
27576789-7	2016	Orally fed iron saturated bLf-Dox inhibited tumour development, prolonged survival, reduced Dox induced general toxicity, cardiotoxicity, neurotoxicity in TRAMP mice and upregulated serum levels of anti-cancer molecules TNF-alpha, IFN-gamma, CCL4 and CCL17.	Iron	11-15	tumor necrosis factor receptor superfamily, member 25	Mus musculus	155-160
27448041-2	2016	Transferrin, is an essential metal-binding protein responsible for iron transport and proper foetal development.	Iron	67-71	transferrin	Homo sapiens	0-11
27448041-7	2016	Transferrin isoforms showed positive correlation with lowered iron stores in the blood of non-smoking women.	Iron	62-66	transferrin	Homo sapiens	0-11
27170339-2	2016	Vitamin C acts as an enzyme cofactor and enhances mobilization of the ferrous form of iron to transferrin thus increasing its bioavailability.	Iron	86-90	transferrin	Homo sapiens	94-105
27399352-11	2016	Upon structural analysis, near-identical folds, protein contact areas, and orientations of heme/iron-sulfur cluster suggested that both mutations may destabilize the CYP27B1-FDX1 complex by negating directional interactions with adrenodoxin.	Iron	96-100	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	166-173
27465531-5	2016	Transferrin-mediated iron uptake by regenerating myofibers occurs independently of systemic iron homeostasis.	Iron	21-25	transferrin	Homo sapiens	0-11
27479815-3	2016	Nuclear factor-erythroid 2 transgenic mice show both a reticulocytosis and a concomitant increase in iron deposits in the spleen, suggesting both enhanced erythrocyte production and increased red blood cell destruction.	Iron	101-105	nuclear factor, erythroid 2	Homo sapiens	0-26
27356954-4	2016	One of biological sources of iron ions are iron-rich proteins, such as transferrin or ferritin.	Iron	29-33	transferrin	Homo sapiens	71-82
27356954-4	2016	One of biological sources of iron ions are iron-rich proteins, such as transferrin or ferritin.	Iron	43-47	transferrin	Homo sapiens	71-82
27515221-5	2016	Most likely, metabolic changes are caused by inhibition of mechanistic target of rapamycin (mTOR), a positive target of tumor growth suppression, but also a regulator of iron homeostasis.	Iron	170-174	mechanistic target of rapamycin kinase	Homo sapiens	92-96
27515221-6	2016	There are no clinical studies reporting changes in iron and ferritin levels during mRCC biotherapy, but we hypothesize that inhibition of mTOR will also affect iron and ferritin levels.	Iron	160-164	mechanistic target of rapamycin kinase	Homo sapiens	138-142
27515221-7	2016	If both lipid and iron changes correlate, there is a high possibility that both changes are primarily caused by mTOR inhibition and the level of change should correlate with the inhibition of mTOR pathway and hence the efficacy of targeted treatment.	Iron	18-22	mechanistic target of rapamycin kinase	Homo sapiens	112-116
27515221-7	2016	If both lipid and iron changes correlate, there is a high possibility that both changes are primarily caused by mTOR inhibition and the level of change should correlate with the inhibition of mTOR pathway and hence the efficacy of targeted treatment.	Iron	18-22	mechanistic target of rapamycin kinase	Homo sapiens	192-196
25522735-3	2016	The main aim of this study was to investigate whether cortical phase shifts on T2 *-weighted images at 7 T in subjects with SCI can be detected, possibly implicating the deposition of Abeta plaques and associated iron.	Iron	213-217	amyloid beta precursor protein	Homo sapiens	184-189
27576789-7	2016	Orally fed iron saturated bLf-Dox inhibited tumour development, prolonged survival, reduced Dox induced general toxicity, cardiotoxicity, neurotoxicity in TRAMP mice and upregulated serum levels of anti-cancer molecules TNF-alpha, IFN-gamma, CCL4 and CCL17.	Iron	11-15	tumor necrosis factor	Mus musculus	220-229
27576789-7	2016	Orally fed iron saturated bLf-Dox inhibited tumour development, prolonged survival, reduced Dox induced general toxicity, cardiotoxicity, neurotoxicity in TRAMP mice and upregulated serum levels of anti-cancer molecules TNF-alpha, IFN-gamma, CCL4 and CCL17.	Iron	11-15	interferon gamma	Mus musculus	231-240
27576789-7	2016	Orally fed iron saturated bLf-Dox inhibited tumour development, prolonged survival, reduced Dox induced general toxicity, cardiotoxicity, neurotoxicity in TRAMP mice and upregulated serum levels of anti-cancer molecules TNF-alpha, IFN-gamma, CCL4 and CCL17.	Iron	11-15	chemokine (C-C motif) ligand 17	Mus musculus	251-256
28773813-0	2016	Synthesis and Characterization of Reduced Graphene Oxide-Supported Nanoscale Zero-Valent Iron (nZVI/rGO) Composites Used for Pb(II) Removal.	Iron	89-93	submaxillary gland androgen regulated protein 3B	Homo sapiens	125-131
27561236-1	2016	We report on the out-of-plane thermal conductivities of tetragonal L10 FePt (001) easy-axis and cubic A1 FePt thin films via time-domain thermoreflectance over a temperature range from 133 K to 500 K. The out-of-plane thermal conductivity of the chemically ordered L10 phase with alternating Fe and Pt layers is ~23% greater than the thermal conductivity of the disordered A1 phase at room temperature and below.	Iron	71-73	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	67-70
27532773-0	2016	Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients.	Iron	25-29	Nfu1p	Saccharomyces cerevisiae S288C	8-12
27532773-6	2016	Given these observations, we propose that Nfu1, assisted by Bol3, functions to facilitate Fe-S transfer from the biosynthetic apparatus to the client proteins preventing oxidative damage to [4Fe-4S] clusters.	Iron	90-94	Nfu1p	Saccharomyces cerevisiae S288C	42-46
27532424-7	2016	Lipid metabolism was the main pathway observed in the analysis of metabolic and canonical signaling pathways for the genes identified as DE, including the genes FASN, FABP4, and THRSP, which are functional candidates for beef quality, suggesting reduced lipogenic activities with lower iron content.	Iron	286-290	fatty acid-binding protein, adipocyte	Bos taurus	167-172
27441502-1	2016	To improve the selectivity, delivery, and activity of ferric (Fe) anticancer agents, we design prodrugs based on N-donor residues of the human serum albumin (HSA) carrier IIA subdomain.	Iron	62-64	albumin	Homo sapiens	143-162
27441502-3	2016	HSA complex structure revealed that Fe compound binds to the hydrophobic cavity in the HSA IIA subdomain.	Iron	36-38	albumin	Homo sapiens	0-3
27441502-3	2016	HSA complex structure revealed that Fe compound binds to the hydrophobic cavity in the HSA IIA subdomain.	Iron	36-38	albumin	Homo sapiens	87-90
27441502-4	2016	Lys199 and His242 of HSA replace the two Cl atoms of Fe compound, coordinating with Fe(3+).	Iron	53-55	albumin	Homo sapiens	21-24
26460882-0	2016	Catalase purification from rat liver with iron-chelated poly(hydroxyethyl methacrylate-N-methacryloyl-(l)-glutamic acid) cryogel discs.	Iron	42-46	catalase	Rattus norvegicus	0-8
27302059-0	2016	Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2.	Iron	0-4	poly(rC) binding protein 2	Homo sapiens	85-90
27302059-5	2016	Subsequently, PCBP2 receives iron from DMT1 and then disengages from the transporter.	Iron	29-33	poly(rC) binding protein 2	Homo sapiens	14-19
27302059-6	2016	In this study, we investigated the function of PCBP2 in iron export.	Iron	56-60	poly(rC) binding protein 2	Homo sapiens	47-52
27302059-11	2016	The silencing of PCBP2 expression suppressed FPN1-dependent iron export from cells.	Iron	60-64	poly(rC) binding protein 2	Homo sapiens	17-22
27302059-12	2016	These results suggest that FPN1 exports iron received from the iron chaperone PCBP2.	Iron	40-44	poly(rC) binding protein 2	Homo sapiens	78-83
27302059-13	2016	Therefore, it was found that PCBP2 modulates cellular iron export, which is an important physiological process.	Iron	54-58	poly(rC) binding protein 2	Homo sapiens	29-34
27288519-9	2016	Ex12 mice showed decreased expression of hepcidin and increased expression of transferrin receptor-1 and erythroferrone, suggesting that the strong erythroid phenotype in Ex12 mutant mice is favored by changes in iron metabolism that optimize iron availability to allow maximal production of red cells.	Iron	213-217	erythroferrone	Mus musculus	78-119
27288519-9	2016	Ex12 mice showed decreased expression of hepcidin and increased expression of transferrin receptor-1 and erythroferrone, suggesting that the strong erythroid phenotype in Ex12 mutant mice is favored by changes in iron metabolism that optimize iron availability to allow maximal production of red cells.	Iron	243-247	erythroferrone	Mus musculus	78-119
25533354-8	2016	Our results show that high concentrations of PAHs and elemental Ni were strongly associated with high apoptosis rates and high expression of IL-1beta, in addition, Fe element was associated with the ROS level, furthermore, Fe and Cr element were associated with DNA damage in BEAS-2B cells.	Iron	223-225	interleukin 1 beta	Homo sapiens	141-149
27503259-13	2016	CONCLUSION: Beyond our current view of iron metabolism in insects, with ferritin and transferrin as its key players, this study provides a comprehensive catalogue of genes with possible roles in the acquisition; transport and storage of iron hence iron homeostasis in the tsetse fly.	Iron	237-241	transferrin	Homo sapiens	85-96
27503259-13	2016	CONCLUSION: Beyond our current view of iron metabolism in insects, with ferritin and transferrin as its key players, this study provides a comprehensive catalogue of genes with possible roles in the acquisition; transport and storage of iron hence iron homeostasis in the tsetse fly.	Iron	237-241	transferrin	Homo sapiens	85-96
27226592-1	2016	Clathrin-mediated endocytosis of transferrin (Tf) and its cognate receptor (TfR1) is a central pathway supporting the uptake of trophic iron.	Iron	136-140	transferrin	Homo sapiens	33-44
27226592-1	2016	Clathrin-mediated endocytosis of transferrin (Tf) and its cognate receptor (TfR1) is a central pathway supporting the uptake of trophic iron.	Iron	136-140	transferrin	Homo sapiens	46-48
27222135-4	2016	Iron supplementation stimulated cardiomyocyte hypertrophy and led to an increase in cardiac protein carbonyls, nitrotyrosine (3-NT) formation, and iNOS protein expression, thus resulting in abnormal myocardium calcium homeostasis of diabetic rats.	Iron	0-4	nitric oxide synthase 2	Rattus norvegicus	147-151
27287367-1	2016	The serine protease matriptase-2 has attracted much attention as a potential target for the treatment of iron overload diseases.	Iron	105-109	transmembrane serine protease 6	Homo sapiens	20-32
27245739-5	2016	Knockout or knockdown of Atg5 (autophagy-related 5) and Atg7 limited erastin-induced ferroptosis with decreased intracellular ferrous iron levels, and lipid peroxidation.	Iron	126-138	autophagy related 5	Homo sapiens	25-29
27245739-5	2016	Knockout or knockdown of Atg5 (autophagy-related 5) and Atg7 limited erastin-induced ferroptosis with decreased intracellular ferrous iron levels, and lipid peroxidation.	Iron	126-138	autophagy related 5	Homo sapiens	31-50
27478448-1	2016	INTRODUCTION: In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy.	Iron	81-85	paraoxonase 1	Homo sapiens	47-60
27478448-1	2016	INTRODUCTION: In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy.	Iron	81-85	paraoxonase 1	Homo sapiens	62-67
27168353-8	2016	It was found that treatment of animals with DFO significantly counteracted the changes in liver function; histopathological lesions and hepatic iron deposition that were induced by CCl4 .	Iron	144-148	C-C motif chemokine ligand 4	Rattus norvegicus	181-185
25533354-8	2016	Our results show that high concentrations of PAHs and elemental Ni were strongly associated with high apoptosis rates and high expression of IL-1beta, in addition, Fe element was associated with the ROS level, furthermore, Fe and Cr element were associated with DNA damage in BEAS-2B cells.	Iron	164-166	interleukin 1 beta	Homo sapiens	141-149
27387771-6	2016	It was observed that spatiotemporal changes in intracellular labile iron, induced by H2O2, influenced the oxidation pattern of the upstream MAP3K ASK1 and promoted the sustained activation of JNK-p38 axis in a defined time-dependent context.	Iron	68-72	mitogen-activated protein kinase 14	Homo sapiens	196-199
27343690-3	2016	Absence of alpha-syn in knock-out mice (alpha-syn(-/-)) resulted in down-regulation of ferritin in the neuroretina, indicating depletion of cellular iron stores.	Iron	149-153	joined toes	Mus musculus	17-20
27387771-0	2016	Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis.	Iron	21-25	mitogen-activated protein kinase 14	Homo sapiens	107-110
27418684-8	2016	Following administration of intravenous iron, values for ferritin concentration, transferrin saturation, and hepcidin concentration rose significantly (P &lt; 0.001, P &lt; 0.005, and P &lt; 0.001, respectively), and values for transferrin concentration fell significantly (P &lt; 0.001).	Iron	40-44	transferrin	Homo sapiens	81-92
27037625-0	2016	Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity.	Iron	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
27418684-8	2016	Following administration of intravenous iron, values for ferritin concentration, transferrin saturation, and hepcidin concentration rose significantly (P &lt; 0.001, P &lt; 0.005, and P &lt; 0.001, respectively), and values for transferrin concentration fell significantly (P &lt; 0.001).	Iron	40-44	transferrin	Homo sapiens	228-239
27316684-3	2016	We therefore investigated the role of heme oxygenase-1 (HO-1), which catalyzes the degradation of heme into the bilirubin precursor biliverdin, ferrous iron, and CO during B. pseudomallei infection.	Iron	152-156	heme oxygenase 1	Mus musculus	56-60
26856732-9	2016	Among women in Wave 1, consumption of iron absorption enhancing foods (green vegetables and fruits high in vitamin C) was protective against anemia (p = 0.043).	Iron	38-42	WASP family member 1	Homo sapiens	15-21
26905070-6	2016	In plasma containing iron and carbon monoxide modified fibrinogen, which may be found in patients at risk of stroke, the coagulation kinetic differences observed with venom was still more vigorous than that seen with thrombin.	Iron	21-25	coagulation factor II, thrombin	Homo sapiens	217-225
27173029-0	2016	Beneficial Effects of Multitarget Iron Chelator on Central Nervous System and Gastrocnemius Muscle in SOD1(G93A) Transgenic ALS Mice.	Iron	34-38	superoxide dismutase 1, soluble	Mus musculus	102-106
27206843-0	2016	A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity.	Iron	60-64	amyloid beta precursor protein	Homo sapiens	11-36
27206843-10	2016	We propose the following cascade for Lead (Pb) toxicity to neurons; by targeting the interaction between Iron regulatory protein-1 and Iron-responsive elements, Pb caused translational repression of proteins that control intracellular iron homeostasis, including the Alzheimer"s amyloid precursor protein (APP) that stabilizes the iron exporter ferroportin, and the ferroxidase heavy subunit of the iron-storage protein, ferritin.	Iron	105-109	amyloid beta precursor protein	Homo sapiens	279-304
26099311-10	2016	ICH initiated endogenous iron chelators and transporters, both exogenous iron chelators enhanced expression of transferrin and transferrin receptor.	Iron	25-29	transferrin	Rattus norvegicus	127-138
26099311-10	2016	ICH initiated endogenous iron chelators and transporters, both exogenous iron chelators enhanced expression of transferrin and transferrin receptor.	Iron	73-77	transferrin	Rattus norvegicus	111-122
26099311-10	2016	ICH initiated endogenous iron chelators and transporters, both exogenous iron chelators enhanced expression of transferrin and transferrin receptor.	Iron	73-77	transferrin	Rattus norvegicus	127-138
27091031-9	2016	Based on iron homeostasis disturbance, we postulated that prior induction of ferritin, through Nrf2 activation after oxidative stress, may be associated with the alteration of melphalan metabolism.	Iron	9-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
27358414-10	2016	Duodenal mucosal tumor necrosis factor alpha (TNFA), interleukin (IL) 1beta, and IL6 relative gene expression was upregulated by 36%, 28%, and 45%, respectively, in H-Fe pigs (P &lt; 0.05), but not in L-Fe pigs, compared with A-Fe pigs.	Iron	167-169	interleukin-1 beta	Sus scrofa	53-75
27101449-7	2016	PM2.5 from dust/soil and several crustal and transition metals, including strontium, iron, titanium, cobalt and magnesium, were significantly associated with increases in ET-1 at 1-day average; manganese and potassium were significantly associated with increases in ICAM-1 at 2-day average; and PM2.5 from industry and metal cadmium were significantly associated with decreases in VCAM-1 at 1-day average.	Iron	85-89	endothelin 1	Homo sapiens	171-175
27473977-7	2016	It was also noted that application of chelated iron can increase production of T CD8(+) cytotoxic cells and IL-2, which promotes the body"s natural response to developing inflammation.	Iron	47-51	interleukin 15	Gallus gallus	108-112
27166425-1	2016	The cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery comprises 11 essential components and matures Fe-S proteins involved in translation and genome maintenance.	Iron	27-31	nuclear receptor coactivator 5	Homo sapiens	51-54
27441659-7	2016	We found that the expression of transferrin, which is responsible for the transport of iron into cells, is increased following treatment with lapatinib alone or in combination with siramesine.	Iron	87-91	transferrin	Homo sapiens	32-43
27307498-1	2016	The transferrin receptor is the primary means of iron importation for most mammalian cells and understanding its regulatory mechanisms is relevant to hematologic, oncologic, and other disorders in which iron homeostasis is perturbed.	Iron	49-53	transferrin	Homo sapiens	4-15
27307498-1	2016	The transferrin receptor is the primary means of iron importation for most mammalian cells and understanding its regulatory mechanisms is relevant to hematologic, oncologic, and other disorders in which iron homeostasis is perturbed.	Iron	203-207	transferrin	Homo sapiens	4-15
27547395-6	2016	Mean daily total dietary intakes of Fe, Zn, vitamin A and vitamin D were significantly higher in the fortified milk group.	Iron	36-38	Weaning weight-maternal milk	Bos taurus	111-115
27427956-1	2016	The eukaryotic protein Isd11 is a chaperone that binds and stabilizes the central component of the essential metabolic pathway responsible for formation of iron-sulfur clusters in mitochondria, the desulfurase Nfs1.	Iron	156-160	LYR motif containing 4	Homo sapiens	23-28
27166425-4	2016	Dre2 contains eight conserved cysteine residues as potential co-ordinating ligands for Fe-S clusters but their functional importance and the type of bound clusters is unclear.	Iron	87-91	cytokine induced apoptosis inhibitor 1	Homo sapiens	0-4
27166425-1	2016	The cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery comprises 11 essential components and matures Fe-S proteins involved in translation and genome maintenance.	Iron	27-29	nuclear receptor coactivator 5	Homo sapiens	51-54
27166425-7	2016	The N-terminal methyltransferase-like domain of Dre2 is important for proper Fe-S cluster assembly at motifs I and II, which occurs in an interdependent fashion.	Iron	77-81	cytokine induced apoptosis inhibitor 1	Homo sapiens	48-52
27259810-0	2016	(56)Fe ion irradiation induced apoptosis through Nrf2 pathway in mouse testis.	Iron	4-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
28773690-2	2016	The authors focus on materials produced from the iron powder (Fe) of ASC 100.29 and Distaloy SE.	Iron	62-64	PYD and CARD domain containing	Homo sapiens	69-72
27115333-0	2016	Nanoscaled zero valent iron/graphene composite as an efficient adsorbent for Co(II) removal from aqueous solution.	Iron	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
27115333-1	2016	A magnetic graphene, i.e., nanoscaled zero valent iron/graphene (0FG) composite, was prepared, characterized and applied for the removal of Co(II) from aqueous solution.	Iron	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
27178558-1	2016	In this work, polyethyleneimine grafted silica-coated nanoscale zero valent iron (Fe@SiO2@PEI) has been successfully synthesized and was investigated to be an effective adsorbent for efficient enrichment of five phthalate esters such as diphenyl phthalate, dibenzyl phthalate, butyl benzyl phthalate, diphenyl isophthalate, and dicyclohexyl phthalate (DPP, DBP, BBP, DPIP, and DCHP) from environmental water samples.	Iron	76-80	D-box binding PAR bZIP transcription factor	Homo sapiens	357-360
27405729-4	2016	Yap1 effect is mediated at least in part through up-regulation of two highly conserved genes controlling cytosolic Fe-S biosynthesis and oxidative stress, Dre2 and Tah18.	Iron	115-119	cytokine induced apoptosis inhibitor 1	Homo sapiens	155-159
26549031-5	2016	The hydroxyl radical, which is produced in a Fenton reaction catalyzed by an iron ion, serves as a potent DNA-DSB-inducing molecule, raising the potential of an iron ion transporter of transferrin in the formation of DNA-DSBs.	Iron	77-81	transferrin	Homo sapiens	185-196
26549031-5	2016	The hydroxyl radical, which is produced in a Fenton reaction catalyzed by an iron ion, serves as a potent DNA-DSB-inducing molecule, raising the potential of an iron ion transporter of transferrin in the formation of DNA-DSBs.	Iron	161-165	transferrin	Homo sapiens	185-196
27178558-1	2016	In this work, polyethyleneimine grafted silica-coated nanoscale zero valent iron (Fe@SiO2@PEI) has been successfully synthesized and was investigated to be an effective adsorbent for efficient enrichment of five phthalate esters such as diphenyl phthalate, dibenzyl phthalate, butyl benzyl phthalate, diphenyl isophthalate, and dicyclohexyl phthalate (DPP, DBP, BBP, DPIP, and DCHP) from environmental water samples.	Iron	82-84	D-box binding PAR bZIP transcription factor	Homo sapiens	357-360
27184405-5	2016	Ferroportin 1 is identified as a cellular iron exporter and required for normal iron cycling.	Iron	42-46	solute carrier family 40 member 1	Danio rerio	0-13
27184405-5	2016	Ferroportin 1 is identified as a cellular iron exporter and required for normal iron cycling.	Iron	80-84	solute carrier family 40 member 1	Danio rerio	0-13
27184405-6	2016	In zebrafish, the mutant of ferroportin 1 gene (fpn1), weh(tp85c) exhibited the defective iron transport, leading to developing severe hypochromic anemia.	Iron	90-94	solute carrier family 40 member 1	Danio rerio	28-41
27184405-6	2016	In zebrafish, the mutant of ferroportin 1 gene (fpn1), weh(tp85c) exhibited the defective iron transport, leading to developing severe hypochromic anemia.	Iron	90-94	solute carrier family 40 member 1	Danio rerio	48-52
27282570-0	2016	Recombinant human erythropoietin-induced erythropoiesis regulates hepcidin expression over iron status in the rat.	Iron	91-95	erythropoietin	Homo sapiens	18-32
27235625-2	2016	We also describe novel interactions between POLE1 and the iron-sulfur cluster assembly complex CIA proteins CIAO1 and MMS19.	Iron	58-62	DNA polymerase epsilon, catalytic subunit	Homo sapiens	44-49
27026547-4	2016	The results showed that the major component of SOD was chemical SOD due to iron predominate.	Iron	75-79	superoxide dismutase 1	Homo sapiens	47-50
27026547-4	2016	The results showed that the major component of SOD was chemical SOD due to iron predominate.	Iron	75-79	superoxide dismutase 1	Homo sapiens	64-67
27113814-0	2016	Relationships of iron metabolism with insulin resistance and glucose levels in young and healthy adults.	Iron	17-21	insulin	Homo sapiens	38-45
27113814-9	2016	CONCLUSIONS: Markers of insulin resistance are strongly related with markers of iron metabolism in healthy subjects.	Iron	80-84	insulin	Homo sapiens	24-31
27138103-0	2016	Deferoxamine-induced increase in the intracellular iron levels in highly aggressive breast cancer cells leads to increased cell migration by enhancing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling.	Iron	51-55	tumor necrosis factor	Homo sapiens	151-160
27130034-0	2016	Iron-sulfur cluster damage by the superoxide radical in neural tissues of the SOD1(G93A) ALS rat model.	Iron	0-4	superoxide dismutase 1	Rattus norvegicus	78-82
27130034-3	2016	In this paper, the state of iron in the neural tissues isolated from SOD1(G93A) transgenic rats was investigated using low temperature EPR spectroscopy and is compared with that of nontransgenic (NTg) littermates.	Iron	28-32	superoxide dismutase 1	Rattus norvegicus	69-73
27030146-4	2016	De novo mutations in WDR45 cause beta-propeller protein-associated neurodegeneration characterized by iron accumulation in the basal ganglia.	Iron	102-106	WD repeat domain 45	Homo sapiens	21-26
27138103-0	2016	Deferoxamine-induced increase in the intracellular iron levels in highly aggressive breast cancer cells leads to increased cell migration by enhancing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling.	Iron	51-55	nuclear factor kappa B subunit 1	Homo sapiens	171-180
27138103-0	2016	Deferoxamine-induced increase in the intracellular iron levels in highly aggressive breast cancer cells leads to increased cell migration by enhancing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling.	Iron	51-55	transforming growth factor beta 1	Homo sapiens	195-203
27138103-9	2016	Collectively, our study has provided the first evidence suggesting that increased intracellular iron levels could lead to enhanced migration of aggressive breast cancer cells by increasing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling.	Iron	96-100	tumor necrosis factor	Homo sapiens	189-198
27138103-9	2016	Collectively, our study has provided the first evidence suggesting that increased intracellular iron levels could lead to enhanced migration of aggressive breast cancer cells by increasing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling.	Iron	96-100	nuclear factor kappa B subunit 1	Homo sapiens	209-218
27138103-9	2016	Collectively, our study has provided the first evidence suggesting that increased intracellular iron levels could lead to enhanced migration of aggressive breast cancer cells by increasing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling.	Iron	96-100	transforming growth factor beta 1	Homo sapiens	233-241
27095095-7	2016	Since oxidative stress is also a general cause of mitochondrial impairment, cells were exposed to test compounds in the presence of transferrin to increase the generation of reactive oxygen species via increased uptake of iron.	Iron	222-226	transferrin	Rattus norvegicus	132-143
27178802-3	2016	Recently, we reported that the flavoprotein Tah18, which was previously shown to transfer electrons to the iron-sulfur cluster protein Dre2, is involved in NOS-like activity in the yeast Saccharomyces cerevisiae.	Iron	107-111	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	44-49
27178802-3	2016	Recently, we reported that the flavoprotein Tah18, which was previously shown to transfer electrons to the iron-sulfur cluster protein Dre2, is involved in NOS-like activity in the yeast Saccharomyces cerevisiae.	Iron	107-111	electron carrier DRE2	Saccharomyces cerevisiae S288C	135-139
27261274-3	2016	Early kinetic studies provided valuable data on the initial uptake of maternal transferrin, an iron-binding protein, by the placenta.	Iron	95-99	transferrin	Homo sapiens	79-90
27324098-10	2016	Paradoxically, a superoxide dismutase (SOD) reversed the inhibition of progesterone synthesis only minimally although it strongly inhibited PQ stimulated iron-dependent lipid peroxidation.	Iron	154-158	superoxide dismutase 1	Homo sapiens	17-37
27324098-10	2016	Paradoxically, a superoxide dismutase (SOD) reversed the inhibition of progesterone synthesis only minimally although it strongly inhibited PQ stimulated iron-dependent lipid peroxidation.	Iron	154-158	superoxide dismutase 1	Homo sapiens	39-42
26558919-6	2016	Percentage of transferrin saturation was calculated using serum iron and total iron binding capacity values.	Iron	64-68	transferrin	Homo sapiens	14-25
26558919-6	2016	Percentage of transferrin saturation was calculated using serum iron and total iron binding capacity values.	Iron	79-83	transferrin	Homo sapiens	14-25
27250827-2	2016	We aimed to study the pathophysiology of EBI and explore the role of hepcidin, a protein involved in iron homeostatic regulation, and its downstream proteins.	Iron	101-105	hepcidin antimicrobial peptide	Rattus norvegicus	69-77
27250827-11	2016	In conclusion, downregulation of ferroportin-1 and ceruloplasmin caused by hepcidin enhanced iron-dependent oxidative damage and may be the potential mechanism of SAH.	Iron	93-97	solute carrier family 40 member 1	Rattus norvegicus	33-46
27250827-11	2016	In conclusion, downregulation of ferroportin-1 and ceruloplasmin caused by hepcidin enhanced iron-dependent oxidative damage and may be the potential mechanism of SAH.	Iron	93-97	hepcidin antimicrobial peptide	Rattus norvegicus	75-83
27365303-2	2016	Iron-refractory IDA (IRIDA) has recently been described as an inherited cause of IDA due to loss-of-function mutations in the TMPRSS6 gene.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	126-133
27356602-12	2016	However, it should be considered that overexpression of the SOD1 gene usually leads to increased SOD1 enzymatic activity, a condition which does not occur in human pathology and which may itself change the expression of iron metabolism genes.	Iron	220-224	superoxide dismutase 1	Homo sapiens	60-64
26803514-5	2016	We also found that iron chelators induced reactive oxygen species (ROS) production, resulting in the activation of both c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in gastric cancer cells.	Iron	19-23	mitogen-activated protein kinase 8	Homo sapiens	120-143
26803514-5	2016	We also found that iron chelators induced reactive oxygen species (ROS) production, resulting in the activation of both c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in gastric cancer cells.	Iron	19-23	mitogen-activated protein kinase 8	Homo sapiens	145-148
26803514-6	2016	Taken together, our data suggest that iron chelators induced apoptosis in gastric cancer, involving ROS formation ER stress and JNK activation.	Iron	38-42	mitogen-activated protein kinase 8	Homo sapiens	128-131
27356602-12	2016	However, it should be considered that overexpression of the SOD1 gene usually leads to increased SOD1 enzymatic activity, a condition which does not occur in human pathology and which may itself change the expression of iron metabolism genes.	Iron	220-224	superoxide dismutase 1	Homo sapiens	97-101
27181360-0	2016	Iron participated in breast cancer chemoresistance by reinforcing IL-6 paracrine loop.	Iron	0-4	interleukin 6	Homo sapiens	66-70
27181360-7	2016	Furthermore, Iron reinforced the IL-6 paracrine loop between TAMs and tumor cells resulting in enhanced chemo-resistance.	Iron	13-17	interleukin 6	Homo sapiens	33-37
27181360-8	2016	Targeting iron metabolism could disturb the reciprocal interaction between tumor cells and TAMs, breaking the local IL-6 rich niche and blocking IL-6 signaling pathway, which could be promising strategy to overcome chemo-resistance.	Iron	10-14	interleukin 6	Homo sapiens	116-120
27181360-8	2016	Targeting iron metabolism could disturb the reciprocal interaction between tumor cells and TAMs, breaking the local IL-6 rich niche and blocking IL-6 signaling pathway, which could be promising strategy to overcome chemo-resistance.	Iron	10-14	interleukin 6	Homo sapiens	145-149
27348013-16	2016	Increased ROS, IL-1beta, acetaldehyde, and increased hepatic iron, all activate nuclear factor-kappa B (NF-kappaB) transcription factor.	Iron	61-65	nuclear factor kappa B subunit 1	Homo sapiens	80-102
27343351-4	2016	We show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2).	Iron	66-70	Phosphoinositide-dependent kinase 1	Drosophila melanogaster	152-197
27343351-4	2016	We show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2).	Iron	66-70	Phosphoinositide-dependent kinase 1	Drosophila melanogaster	199-203
27348013-16	2016	Increased ROS, IL-1beta, acetaldehyde, and increased hepatic iron, all activate nuclear factor-kappa B (NF-kappaB) transcription factor.	Iron	61-65	nuclear factor kappa B subunit 1	Homo sapiens	104-113
27310832-8	2016	Linear regression analysis showed that erythropoietin levels in chronic kidney disease, anemia of chronic disease and anemia of unknown etiology were lower by 48%, 46% and 27%, respectively, compared to iron deficiency anemia even after adjusting for hemoglobin, eGFR and comorbidities.	Iron	203-207	erythropoietin	Homo sapiens	39-53
27498743-1	2016	Erythropoiesis requires large amounts of iron for hemoglobin synthesis, which is mainly provided by macrophages and the intestines in a transferrin (Tf)-bound form.	Iron	41-45	transferrin	Homo sapiens	136-147
27398158-7	2016	Furthermore, reduced expression of liver hepcidin mRNA and p-STAT3 expression, as well as increased hemoglobin concentration, hematocrit, levels of serum iron, transferrin saturation and splenic iron stores were found in IL-10(-/-) mice after MaR1 treatment (P&lt;0.05).	Iron	154-158	interleukin 10	Mus musculus	221-226
27214780-2	2016	Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and beta-thalassemia.	Iron	88-92	transmembrane serine protease 6	Homo sapiens	14-26
27398158-7	2016	Furthermore, reduced expression of liver hepcidin mRNA and p-STAT3 expression, as well as increased hemoglobin concentration, hematocrit, levels of serum iron, transferrin saturation and splenic iron stores were found in IL-10(-/-) mice after MaR1 treatment (P&lt;0.05).	Iron	195-199	interleukin 10	Mus musculus	221-226
27277810-7	2016	Acute OL loss was accompanied by reduced ferritin expression, which is regulated by TLR4 and needed for effective iron storage.	Iron	114-118	toll-like receptor 4	Mus musculus	84-88
27214780-1	2016	Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis.	Iron	81-85	transmembrane serine protease 6	Homo sapiens	0-12
27277810-15	2016	We show that TLR4 signaling is essential for acute iron storage, regulating cytokine and growth factor expression, and efficient myelin debris clearance, all of which influence OL replacement.	Iron	51-55	toll-like receptor 4	Mus musculus	13-17
26999720-6	2016	Elevated iron levels were defined by high serum ferritin (SF&gt;110 mug/L in women and&gt;200 mug/L in men) and/or transferrin saturation (TS)&gt;45%.	Iron	9-13	transferrin	Homo sapiens	115-126
26998861-6	2016	To access iron from host stores, L. pneumophila upregulates more regions allowing vacuolar colocalization N. In response to Legionella, the host cell may activate caspase-1, caspase-11 (mice) or caspase-4 (humans).	Iron	10-14	caspase 4, apoptosis-related cysteine peptidase	Mus musculus	195-204
26850692-7	2016	Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway.	Iron	0-4	transferrin	Homo sapiens	33-44
26850692-7	2016	Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway.	Iron	0-4	transferrin	Homo sapiens	59-70
26850692-7	2016	Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway.	Iron	0-4	cyclin A2	Homo sapiens	124-139
26934143-8	2016	Hepcidin values correlated with ferritin levels, and serum iron correlated strongly with transferrin saturation.	Iron	59-63	transferrin	Homo sapiens	89-100
26934143-13	2016	CONCLUSIONS: Our findings demonstrate that parameters of iron metabolism, particularly transferrin saturation, that reflect serum iron availability, are strong outcome predictors in ICU patients.	Iron	57-61	transferrin	Homo sapiens	87-98
26934143-13	2016	CONCLUSIONS: Our findings demonstrate that parameters of iron metabolism, particularly transferrin saturation, that reflect serum iron availability, are strong outcome predictors in ICU patients.	Iron	130-134	transferrin	Homo sapiens	87-98
26224043-7	2016	Knockdown of Fas and Bid expression by small interfering RNA in iron-treated HH4 cells resulted in restoration of cell viability.	Iron	64-68	BH3 interacting domain death agonist	Homo sapiens	21-24
26995536-0	2016	Relation between iron metabolism and antioxidants enzymes and delta-ALA-D activity in rats experimentally infected by Fasciola hepatica.	Iron	17-21	aminolevulinate dehydratase	Rattus norvegicus	62-73
27060822-0	2016	Milk protein composition and stability changes affected by iron in water sources.	Iron	59-63	Weaning weight-maternal milk	Bos taurus	0-4
27159390-3	2016	Here, we report that surface expression of GRP78 is increased in endothelial cells exposed to physiological concentrations of beta-hydroxy butyrate (BHB), glucose, and iron that are similar to those found in DKA patients.	Iron	168-172	heat shock protein family A (Hsp70) member 5	Homo sapiens	43-48
27408412-1	2016	Congenital dyserythropoietic anemia type I is an autosomal recessive disorder associated with macrocytic anemia, ineffective erythropoiesis, iron overloading and characterized by abnormal chromatin ultrastructure in erythroblasts such as internuclear chromatin bridges, spongy heterochromatin and invagination of the nuclear membrane.	Iron	141-145	codanin 1	Homo sapiens	0-42
27060822-9	2016	For milk from both abomasal infusion of ferrous lactate and direct addition of ferrous sulfate, an iron concentration as low as 2mg of Fe/L was able to cause oxidative stress in dairy cattle and infused milk, respectively.	Iron	99-103	Weaning weight-maternal milk	Bos taurus	203-207
27060822-3	2016	The objective was to evaluate interaction of water-sourced iron (low, medium, and high levels) on milk proteome and implications on milk oxidative state and mineral content.	Iron	59-63	Weaning weight-maternal milk	Bos taurus	98-102
27060822-12	2016	Direct iron addition to milk led to lipid oxidation during storage at 4 C. Oxidation level was positively associated with the concentration of added iron.	Iron	149-153	Weaning weight-maternal milk	Bos taurus	24-28
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Iron	44-48	Weaning weight-maternal milk	Bos taurus	181-185
27060822-9	2016	For milk from both abomasal infusion of ferrous lactate and direct addition of ferrous sulfate, an iron concentration as low as 2mg of Fe/L was able to cause oxidative stress in dairy cattle and infused milk, respectively.	Iron	99-103	Weaning weight-maternal milk	Bos taurus	4-8
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Iron	44-48	Weaning weight-maternal milk	Bos taurus	239-243
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Iron	114-118	Weaning weight-maternal milk	Bos taurus	181-185
27060822-14	2016	This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality.	Iron	114-118	Weaning weight-maternal milk	Bos taurus	239-243
27544840-1	2016	OBJECTIVES: Altered brain iron homeostasis with regional iron deficiency has been previously reported in several studies of restless legs syndrome (RLS) patients.	Iron	26-30	RLS1	Homo sapiens	148-151
27244448-0	2016	Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification.	Iron	8-12	GLI family zinc finger 2	Homo sapiens	63-68
27244448-5	2016	We elucidated the effects of chronic iron overload on human monocytic cell line (THP-1) and THP-1 derived macrophages (TDM) by continuously exposing them to high levels of iron (100 muM) to create I-THP-1 and I-TDM, respectively.	Iron	37-41	GLI family zinc finger 2	Homo sapiens	81-86
27308268-0	2016	The role of S-methylisothiourea hemisulfate as inducible nitric oxide synthase inhibitor against kidney iron deposition in iron overload rats.	Iron	104-108	nitric oxide synthase 2	Rattus norvegicus	47-78
27308268-3	2016	Iron overload can regulate the expression of inducible nitric oxide synthase (iNOS) in some cells that has an important role in tissue destruction.	Iron	0-4	nitric oxide synthase 2	Rattus norvegicus	45-76
27308268-3	2016	Iron overload can regulate the expression of inducible nitric oxide synthase (iNOS) in some cells that has an important role in tissue destruction.	Iron	0-4	nitric oxide synthase 2	Rattus norvegicus	78-82
27229173-5	2016	We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation.	Iron	58-62	fibrinogen beta chain	Homo sapiens	18-28
27229173-5	2016	We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation.	Iron	58-62	fibrinogen beta chain	Homo sapiens	232-242
27193999-0	2016	The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation.	Iron	14-18	demeter-like 1	Arabidopsis thaliana	99-103
27193999-7	2016	ROS1 activity was reduced in the met18 mutant plants and point mutation in the conserved Fe-S cluster binding motif of ROS1 disrupted its biological function.	Iron	89-93	demeter-like 1	Arabidopsis thaliana	0-4
27193999-7	2016	ROS1 activity was reduced in the met18 mutant plants and point mutation in the conserved Fe-S cluster binding motif of ROS1 disrupted its biological function.	Iron	89-93	demeter-like 1	Arabidopsis thaliana	119-123
26828840-1	2016	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive neurodegeneration with brain iron accumulation and characterized by extrapyramidal signs, vision loss, and intellectual decline.	Iron	111-115	pantothenate kinase 2	Homo sapiens	0-48
26828840-1	2016	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive neurodegeneration with brain iron accumulation and characterized by extrapyramidal signs, vision loss, and intellectual decline.	Iron	111-115	pantothenate kinase 2	Homo sapiens	50-54
27342530-12	2016	CD8+ T cell apoptosis in iron overload group was significantly higher than that in control groups (P&lt;0.01); the expression of BCL-2 at mRNA level was lower than that in control group, but the expression of BAX at mRNA level was higher than that in control group (P&lt;0.05).	Iron	25-29	B cell leukemia/lymphoma 2	Mus musculus	129-134
27342530-14	2016	CONCLUSION: Iron overload can inhibit the ratio of CD8+ T cells of splenic cells in mice, decrease the expression of IFN-gamma, Granzyme-B, increase the apoptosis of CD3+ CD8+/CD8-.	Iron	12-16	interferon gamma	Mus musculus	117-126
27249004-2	2016	Total body iron, calculated from serum ferritin and soluble transferrin receptor concentrations, and hemoglobin allow for monitoring of the iron and anemia status of children in the United States.	Iron	11-15	transferrin	Homo sapiens	60-71
27072134-4	2016	A small C-terminal domain of the catalytic subunit Pol3 carries both iron-sulfur cluster and zinc-binding motifs, which mediate interactions with Pol31, and processive replication with the replication clamp proliferating cell nuclear antigen (PCNA), respectively.	Iron	69-73	DNA-directed DNA polymerase delta subunit POL31	Saccharomyces cerevisiae S288C	146-151
27211820-0	2016	Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex.	Iron	24-28	glycoprotein m6a	Mus musculus	84-87
27211820-5	2016	Ferritin-M6A-expressing C6-glioma cells showed enhanced (per iron) r2 relaxivity.	Iron	61-65	glycoprotein m6a	Mus musculus	9-12
27198537-0	2016	Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice.	Iron	52-56	heme oxygenase 1	Mus musculus	12-16
27544840-3	2016	The purpose of this study was to assess differences in brain iron concentrations between RLS patients and healthy controls and their relation to severity of disease and periodic limb movement during sleep (PLMS).	Iron	61-65	RLS1	Homo sapiens	89-92
26835898-2	2016	The effects of initial pH on the rate of NO3(-) reduction and the Fe(0) surface characteristics revealed Fe(2+)(aq) and the characteristics of minerals on the surface of Fe(0) played an important role in NO3(-) reduction.	Iron	170-175	NBL1, DAN family BMP antagonist	Homo sapiens	204-207
26971013-0	2016	Ferritin, an iron source in meat for Staphylococcus xylosus?	Iron	13-17	ferritin	Staphylococcus xylosus	0-8
26971013-5	2016	Ferritin is a storage protein able to capture large quantities of iron.	Iron	66-70	ferritin	Staphylococcus xylosus	0-8
26971013-7	2016	Surprisingly, we found that the S. xylosus C2a strain grows in the presence of ferritin as a sole iron source.	Iron	98-102	ferritin	Staphylococcus xylosus	79-87
26971013-8	2016	A three-cistron operon was highly overexpressed under ferritin iron growth conditions.	Iron	63-67	ferritin	Staphylococcus xylosus	54-62
26971013-10	2016	The mutant showed decreased growth because it was less able to acquire iron from ferritin.	Iron	71-75	ferritin	Staphylococcus xylosus	81-89
26971013-12	2016	This study characterized for the first time the capacity of a Staphylococcus to use iron from ferritin and revealed that a potential reductive pathway was involved in this acquisition.	Iron	84-88	ferritin	Staphylococcus xylosus	94-102
32262965-10	2016	Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions.	Iron	26-28	alkaline phosphatase, placental	Homo sapiens	65-85
32262965-10	2016	Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions.	Iron	26-28	alkaline phosphatase, placental	Homo sapiens	87-90
32262965-10	2016	Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions.	Iron	26-28	RUNX family transcription factor 2	Homo sapiens	146-151
32262965-10	2016	Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions.	Iron	26-28	bone gamma-carboxyglutamate protein	Homo sapiens	153-156
32262965-10	2016	Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions.	Iron	26-28	integrin binding sialoprotein	Homo sapiens	161-164
26946266-2	2016	Recent work has shown that Dexras1 mediates iron trafficking and NMDA-dependent neurodegeneration but a role for Dexras1 in normal brain function or psychiatric disease has not been studied.	Iron	44-48	RAS, dexamethasone-induced 1	Mus musculus	27-34
27206665-0	2016	Matriptase-2 links erythropoietin to iron.	Iron	37-41	transmembrane serine protease 6	Homo sapiens	0-12
27206665-0	2016	Matriptase-2 links erythropoietin to iron.	Iron	37-41	erythropoietin	Homo sapiens	19-33
26835898-1	2016	The mechanism of the effects of Fe(2+)(aq) on the reduction of NO3(-) by Fe(0) was investigated.	Iron	73-78	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
26835898-2	2016	The effects of initial pH on the rate of NO3(-) reduction and the Fe(0) surface characteristics revealed Fe(2+)(aq) and the characteristics of minerals on the surface of Fe(0) played an important role in NO3(-) reduction.	Iron	66-71	NBL1, DAN family BMP antagonist	Homo sapiens	204-207
26835898-2	2016	The effects of initial pH on the rate of NO3(-) reduction and the Fe(0) surface characteristics revealed Fe(2+)(aq) and the characteristics of minerals on the surface of Fe(0) played an important role in NO3(-) reduction.	Iron	170-175	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
28725729-9	2016	Dietary iron overload altered the radiation response observed in serum analytes, as evidenced by a significant increase in catalase levels and smaller decrease in glutathione peroxidase and total antioxidant capacity levels.	Iron	8-12	catalase	Rattus norvegicus	123-131
26835898-7	2016	Electrochemistry measurements confirmed that the spontaneous electron transfer between the Fe(2+) and structural Fe(3+) species accelerated the interfacial electron transfer between the Fe species and NO3(-).	Iron	91-93	NBL1, DAN family BMP antagonist	Homo sapiens	201-204
27070073-1	2016	Human serum transferrin (sTf) is a protein that mediates the transport of iron from blood to cells.	Iron	74-78	transferrin	Homo sapiens	12-23
26969708-6	2016	Interestingly, when simultaneously expressed in ccc1Delta cells, SFerH1 and SFerH2 assembled as heteropolymers, which further increased iron resistance and reduced the oxidative stress produced by excess iron compared to ferritin homopolymer complexes.	Iron	136-140	ferritin-2, chloroplastic	Glycine max	76-82
26969708-6	2016	Interestingly, when simultaneously expressed in ccc1Delta cells, SFerH1 and SFerH2 assembled as heteropolymers, which further increased iron resistance and reduced the oxidative stress produced by excess iron compared to ferritin homopolymer complexes.	Iron	204-208	ferritin-2, chloroplastic	Glycine max	76-82
26928591-4	2016	Searching for physiologically relevant lipid regulators of Cygb, here we report that anionic phospholipids, particularly phosphatidylinositolphosphates, affect structural organization of the protein and modulate its iron state and peroxidase activity both conjointly and/or independently of cysteine oxidation.	Iron	216-220	cytoglobin	Homo sapiens	59-63
26917226-0	2016	Pharmacodynamic Model of Hepcidin Regulation of Iron Homeostasis in Cynomolgus Monkeys.	Iron	48-52	hepcidin	Macaca fascicularis	25-33
26917226-1	2016	Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export.	Iron	98-102	hepcidin	Macaca fascicularis	0-8
27629729-4	2016	OBJECTIVES: The aim of the study was to evaluate the usefulness of determining the reticulocyte hemoglobin content and serum concentration of soluble transferrin receptor in the detection of anemia caused by iron deficiency in comparison with the classic markers of iron circulation in serum in chronic dialysis patients with ESRD.	Iron	208-212	transferrin	Homo sapiens	150-161
27629729-10	2016	Moreover, the concentration of soluble transferrin receptor confirmed its high diagnostic value in the detection of iron deficiency-based anemia in patients undergoing dialysis for chronic renal failure at the end-stage compared to conventional iron turnover ratios in the serum.	Iron	116-120	transferrin	Homo sapiens	39-50
26960903-1	2016	In response to the need for straightforward analytical methods to assess the affinity of molecularly imprinted nanoparticles (MIP NPs) for ligands, capillary electrophoresis (CE) was exploited using MIP NPs targeting the iron-regulating hormone hepcidin.	Iron	221-225	major intrinsic protein of lens fiber	Homo sapiens	126-129
26960903-1	2016	In response to the need for straightforward analytical methods to assess the affinity of molecularly imprinted nanoparticles (MIP NPs) for ligands, capillary electrophoresis (CE) was exploited using MIP NPs targeting the iron-regulating hormone hepcidin.	Iron	221-225	major intrinsic protein of lens fiber	Homo sapiens	199-202
26928591-2	2016	The iron coordination and spin state of the Cygb heme group are sensitive to oxidation of two cysteine residues (Cys38/Cys83) and/or the binding of free fatty acids.	Iron	4-8	cytoglobin	Homo sapiens	44-48
26929401-2	2016	Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion.	Iron	220-224	DNA-directed RNA polymerase II core subunit RPB2	Saccharomyces cerevisiae S288C	59-63
26929401-2	2016	Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion.	Iron	220-224	DNA-directed RNA polymerase II core subunit RPB2	Saccharomyces cerevisiae S288C	128-132
26929401-2	2016	Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion.	Iron	220-224	siderophore transporter	Saccharomyces cerevisiae S288C	157-161
26929401-2	2016	Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion.	Iron	220-224	siderophore transporter	Saccharomyces cerevisiae S288C	119-123
26929401-2	2016	Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion.	Iron	220-224	DNA-directed RNA polymerase II core subunit RPB2	Saccharomyces cerevisiae S288C	128-132
26929401-5	2016	Both sit1 and sit2 were localized to the plasma membrane in A. fumigatus The expression levels of the sit1 and sit2 genes were dependent on hapX under low-but not high-iron conditions.	Iron	168-172	DNA-directed RNA polymerase II core subunit RPB2	Saccharomyces cerevisiae S288C	14-18
26929401-5	2016	Both sit1 and sit2 were localized to the plasma membrane in A. fumigatus The expression levels of the sit1 and sit2 genes were dependent on hapX under low-but not high-iron conditions.	Iron	168-172	DNA-directed RNA polymerase II core subunit RPB2	Saccharomyces cerevisiae S288C	111-115
27067488-8	2016	Thus, our data unearthed EPO-dependent ERFE expression acts as an erythropoiesis-driven regulator of iron metabolism under PHZ-induced hemolytic anemia.	Iron	101-105	erythroferrone	Mus musculus	39-43
26990350-0	2016	Liver iron is a major regulator of hepcidin gene expression via BMP/SMAD pathway in a rat model of chronic renal failure under treatment with high rHuEPO doses.	Iron	6-10	hepcidin antimicrobial peptide	Rattus norvegicus	35-43
26990350-1	2016	Hepcidin is the major central regulator of iron metabolism, controlling iron absorption and mobilization.	Iron	43-47	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
26990350-1	2016	Hepcidin is the major central regulator of iron metabolism, controlling iron absorption and mobilization.	Iron	72-76	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	30-34	bone morphogenetic protein 6	Homo sapiens	370-374
27091216-10	2016	Oxidative stress as a result of IV iron infusions and iron overload, by releasing labile non-transferrin-bound iron, might represent a "second hit" on the vascular bed.	Iron	35-39	transferrin	Homo sapiens	93-104
26797949-4	2016	The results showed that the process of Cr(VI) removal by Fe(0) was divided into three different stages in the presence of NO3 (-): inhibition period (&lt;198 pore volumes (PVs)); promotion period (198~1025 PVs); and complete passivation period (1025~1300 PVs).	Iron	57-62	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
26797949-6	2016	NO3 (-) exhibited the most dominant effect on the Cr(VI) removal by Fe(0) in the last two stages.	Iron	68-73	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
27017620-0	2016	Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.	Iron	0-4	Ferritin	Caenorhabditis elegans	36-44
27017620-2	2016	Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically associated with obesity and obesity-related diseases.	Iron	119-123	Ferritin	Caenorhabditis elegans	49-57
27017620-2	2016	Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically associated with obesity and obesity-related diseases.	Iron	119-123	Ferritin	Caenorhabditis elegans	49-57
27017620-4	2016	Here, using Caenorhabditis elegans, we show that iron overload induces the expression of sgk-1, encoding the serum and glucocorticoid-inducible kinase, to promote the level of ferritin and fat accumulation.	Iron	49-53	Ferritin	Caenorhabditis elegans	176-184
27222740-3	2016	The biochemical bases behind the resistance to erythropoietin therapy with frequent hemoglobinemia, oxidative stress and iron status have not been fully understood.	Iron	121-125	erythropoietin	Homo sapiens	47-61
27305829-1	2016	Due to their abundant ubiquitous presence, rapid uptake and increased requirement in neoplastic tissue, the delivery of the iron carrier macromolecules transferrin (Tf) and lactoferrin (Lf) into mammalian cells is the subject of intense interest for delivery of drugs and other target molecules into cells.	Iron	124-128	transferrin	Homo sapiens	152-163
27305829-1	2016	Due to their abundant ubiquitous presence, rapid uptake and increased requirement in neoplastic tissue, the delivery of the iron carrier macromolecules transferrin (Tf) and lactoferrin (Lf) into mammalian cells is the subject of intense interest for delivery of drugs and other target molecules into cells.	Iron	124-128	transferrin	Homo sapiens	165-167
26835887-8	2016	Iron deficiency was calculated using ferritin and soluble transferrin receptor in the body iron formula.	Iron	91-95	transferrin	Homo sapiens	58-69
26911281-5	2016	The iron-exposed NSCLC H460 and H292 cells exhibited a remarkable increase in propensities to form CSC spheroids and to proliferate, migrate, and invade in parallel with an increase in level of a well-known CSC marker, ABCG2.	Iron	4-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	219-224
27161430-2	2016	To supply adequate iron the carrier transferrin is required together with transferrin receptor endosomal cycle and normal mitochondrial iron utilization.	Iron	19-23	transferrin	Homo sapiens	36-47
27161430-2	2016	To supply adequate iron the carrier transferrin is required together with transferrin receptor endosomal cycle and normal mitochondrial iron utilization.	Iron	136-140	transferrin	Homo sapiens	36-47
27161430-12	2016	Erythroblasts sense circulating iron through the second transferrin receptor (TFR2) that, in animal models, modulates the sensitivity of the erythroid cells to EPO.	Iron	32-36	transferrin	Homo sapiens	56-67
27161430-12	2016	Erythroblasts sense circulating iron through the second transferrin receptor (TFR2) that, in animal models, modulates the sensitivity of the erythroid cells to EPO.	Iron	32-36	erythropoietin	Homo sapiens	160-163
26733407-8	2016	Patients with iron malabsorption [IM] showed higher values of ESR, CRP, and hepcidin [p = 0.02, p = 0.001, and p = 0.06, respectively].	Iron	14-18	C-reactive protein	Homo sapiens	67-70
27091216-10	2016	Oxidative stress as a result of IV iron infusions and iron overload, by releasing labile non-transferrin-bound iron, might represent a "second hit" on the vascular bed.	Iron	54-58	transferrin	Homo sapiens	93-104
27091216-10	2016	Oxidative stress as a result of IV iron infusions and iron overload, by releasing labile non-transferrin-bound iron, might represent a "second hit" on the vascular bed.	Iron	54-58	transferrin	Homo sapiens	93-104
27188730-5	2016	In this study, therefore, iron dependency in HER2 overexpression and CSC survival is examined in breast cancer cell line, MCF7.	Iron	26-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
27066710-8	2016	In vivo transcriptome analysis in mouse blood showed that the WT strain reduced the expression of host genes related to iron-binding by SS9-LysM.	Iron	120-124	lysozyme 2	Mus musculus	140-144
27066710-9	2016	Moreover, the total free iron concentration in blood from infected mice was significantly lower for the DeltaSS9-LysM strain compared with the WT strain.	Iron	25-29	lysozyme 2	Mus musculus	113-117
27066710-10	2016	Together, our data reveal that SS9-LysM facilitates SS survival within blood by releasing more free iron from the host.	Iron	100-104	lysozyme 2	Mus musculus	35-39
26944792-7	2016	Under the conditions tested, the results showed that tcf expression was higher in the fur mutant and was regulated by iron concentration.	Iron	118-122	hepatocyte nuclear factor 4 alpha	Homo sapiens	53-56
26777439-0	2016	Leukocyte production of IFN-gamma and TNF-alpha in 8- to 12-y-old children with low serum iron levels.	Iron	90-94	interferon gamma	Homo sapiens	24-33
27188730-6	2016	It has shown that cells overexpressing HER2 require iron more than their vector counterparts and HER2-increased CSCs are vulnerable to iron chelation.	Iron	52-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-43
27188730-6	2016	It has shown that cells overexpressing HER2 require iron more than their vector counterparts and HER2-increased CSCs are vulnerable to iron chelation.	Iron	135-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-43
26970775-8	2016	By using different Dif1 mutant proteins, we uncover that Dun1 phosphorylates Dif1 Ser-104 and Thr-105 residues upon iron scarcity.	Iron	116-120	Dif1p	Saccharomyces cerevisiae S288C	19-23
26970775-8	2016	By using different Dif1 mutant proteins, we uncover that Dun1 phosphorylates Dif1 Ser-104 and Thr-105 residues upon iron scarcity.	Iron	116-120	Dif1p	Saccharomyces cerevisiae S288C	77-81
26970775-10	2016	Importantly, the Dif1-S104A/T105A mutant exhibits defects in nucleus-to-cytoplasm redistribution of Rnr2-Rnr4 by iron limitation.	Iron	113-117	Dif1p	Saccharomyces cerevisiae S288C	17-21
26970775-11	2016	Taken together, these results reveal that, in response to iron starvation, Dun1 kinase phosphorylates Dif1 to stimulate Rnr2-Rnr4 relocalization to the cytoplasm and promote RNR function.	Iron	58-62	Dif1p	Saccharomyces cerevisiae S288C	102-106
27188730-6	2016	It has shown that cells overexpressing HER2 require iron more than their vector counterparts and HER2-increased CSCs are vulnerable to iron chelation.	Iron	135-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	97-101
27057920-9	2016	The met-Hb readily releases free hemin that directly induces HO-1 in the liver, which metabolizes the hemin into iron, biliverdin, and CO.	Iron	113-117	heme oxygenase 1	Mus musculus	61-65
27121137-2	2016	Formation of amyloid-beta plaque cores (APC) is related to interactions with biometals, especially Fe, Cu and Zn, but their particular structural associations and roles remain unclear.	Iron	99-101	amyloid beta precursor protein	Homo sapiens	13-25
27313332-5	2016	This IGF-1R targeted theranostic nanoparticle delivery system has an iron core for non-invasive MR imaging, amphiphilic polymer coating to ensure the biocompatibility as well as for drug loading and conjugation of recombinant human IGF-1 as targeting molecules.	Iron	69-73	insulin like growth factor 1	Homo sapiens	5-10
27019020-2	2016	A novel coordination environment for Co(II) is observed including a weak but significant Fe-Co interaction, which was characterized using X-ray crystallography, Mossbauer spectroscopy, and VT-magnetometry.	Iron	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
27080392-0	2016	Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1.	Iron	10-14	RAS, dexamethasone-induced 1	Mus musculus	77-84
27080392-1	2016	BACKGROUND: Activation of NMDA receptors can induce iron movement into neurons by the small GTPase Dexras1 via the divalent metal transporter 1 (DMT1).	Iron	52-56	RAS, dexamethasone-induced 1	Mus musculus	99-106
30713952-1	2017	The early-onset classic form of panthotenate kinase-associated neurodegeneration (PKAN) is a rare genetic disorder of brain iron deposition associated with mutations in the pantothenate kinase 2 gene.	Iron	124-128	pantothenate kinase 2	Homo sapiens	32-80
26938575-3	2016	The ground state of Fe 4O is a singlet, hexavalent iron(VI) complex (1)C2v-[Fe(VI)O2](2+)(O2)(2-), with isomers of oxidation states Fe(II), Fe(III), Fe(IV), Fe(V), and Fe(VIII) all lying slightly higher within the range of 1 eV.	Iron	20-22	FEV transcription factor, ETS family member	Homo sapiens	157-162
27068103-1	2016	BACKGROUND: Hepcidin, a key regulator of iron metabolism, is produced mainly by interleukin-6 (IL-6) during inflammation.	Iron	41-45	interleukin 6	Mus musculus	80-93
27068103-1	2016	BACKGROUND: Hepcidin, a key regulator of iron metabolism, is produced mainly by interleukin-6 (IL-6) during inflammation.	Iron	41-45	interleukin 6	Mus musculus	95-99
27068103-12	2016	LC-06-JCK-bearing mice showed lower values of MCV, mean corpuscular hemoglobin (MCH), and serum iron as compared to NTB mice.	Iron	96-100	NIMA (never in mitosis gene a)-related expressed kinase 8	Mus musculus	6-9
27068103-14	2016	CONCLUSIONS: Our results suggest that overproduction of hepcidin by IL-6 signaling might be a major factor that leads to functionally iron-deficient cancer-related anemia in the LC-06-JCK model.	Iron	134-138	interleukin 6	Mus musculus	68-72
27068103-14	2016	CONCLUSIONS: Our results suggest that overproduction of hepcidin by IL-6 signaling might be a major factor that leads to functionally iron-deficient cancer-related anemia in the LC-06-JCK model.	Iron	134-138	NIMA (never in mitosis gene a)-related expressed kinase 8	Mus musculus	184-187
27050837-6	2016	In the rewetted iron-rich cores, a sharp increase in pore water iron (Fe) concentrations correlated with concentrations of inorganic carbon (TIC, &gt; 13 mmol L-1) and dissolved organic carbon (DOC, &gt; 16 mmol L-1).	Iron	16-20	pleckstrin and Sec7 domain containing 4	Homo sapiens	141-144
27050837-6	2016	In the rewetted iron-rich cores, a sharp increase in pore water iron (Fe) concentrations correlated with concentrations of inorganic carbon (TIC, &gt; 13 mmol L-1) and dissolved organic carbon (DOC, &gt; 16 mmol L-1).	Iron	64-68	pleckstrin and Sec7 domain containing 4	Homo sapiens	141-144
27050837-6	2016	In the rewetted iron-rich cores, a sharp increase in pore water iron (Fe) concentrations correlated with concentrations of inorganic carbon (TIC, &gt; 13 mmol L-1) and dissolved organic carbon (DOC, &gt; 16 mmol L-1).	Iron	70-72	pleckstrin and Sec7 domain containing 4	Homo sapiens	141-144
30713952-1	2017	The early-onset classic form of panthotenate kinase-associated neurodegeneration (PKAN) is a rare genetic disorder of brain iron deposition associated with mutations in the pantothenate kinase 2 gene.	Iron	124-128	pantothenate kinase 2	Homo sapiens	82-86
30713952-1	2017	The early-onset classic form of panthotenate kinase-associated neurodegeneration (PKAN) is a rare genetic disorder of brain iron deposition associated with mutations in the pantothenate kinase 2 gene.	Iron	124-128	pantothenate kinase 2	Homo sapiens	173-194
26712506-0	2016	Cytochrome b5 Reductase 1 Triggers Serial Reactions that Lead to Iron Uptake in Plants.	Iron	65-69	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	0-25
26712506-8	2016	Transcript levels of CBR1, fatty acids desaturase2 (FAD2), and fatty acids desaturase3 (FAD3) were increased under Fe-deficient conditions.	Iron	115-117	NADH:cytochrome B5 reductase 1	Arabidopsis thaliana	21-25
27358145-8	2016	It can therefore be summarized that supplementing an iron agent intravenously to maintain SF level between 500 ng/ml and 1200 ng/ml may improve reactivity of patients with MHD to EPO.	Iron	53-57	erythropoietin	Homo sapiens	179-182
26762582-0	2016	En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase-2 as a Target for Kunitz-Type Inhibitors.	Iron	40-44	transmembrane serine protease 6	Homo sapiens	64-76
26762582-1	2016	The cell-surface serine protease matriptase-2 is a critical stimulator of iron absorption by negatively regulating hepcidin, the key hormone of iron homeostasis.	Iron	74-78	transmembrane serine protease 6	Homo sapiens	33-45
26762582-1	2016	The cell-surface serine protease matriptase-2 is a critical stimulator of iron absorption by negatively regulating hepcidin, the key hormone of iron homeostasis.	Iron	144-148	transmembrane serine protease 6	Homo sapiens	33-45
26677772-0	2016	Indicators of iron status are correlated with adiponectin expression in adipose tissue of patients with morbid obesity.	Iron	14-18	adiponectin, C1Q and collagen domain containing	Homo sapiens	46-57
26677772-8	2016	CONCLUSION: Iron content appears to be increased in the SCAT and VAT of obese patients, and negatively correlated with adiponectin expression, which could be contributing to insulin resistance and the metabolic complications of obesity.	Iron	12-16	adiponectin, C1Q and collagen domain containing	Homo sapiens	119-130
26677772-8	2016	CONCLUSION: Iron content appears to be increased in the SCAT and VAT of obese patients, and negatively correlated with adiponectin expression, which could be contributing to insulin resistance and the metabolic complications of obesity.	Iron	12-16	insulin	Homo sapiens	174-181
26173968-1	2016	Variants in the WD repeat 45 (WDR45) gene in human Xp11.23 have recently been identified in patients suffering from neurodegeneration with brain iron accumulation, a genetically and phenotypically heterogeneous condition.	Iron	145-149	WD repeat domain 45	Homo sapiens	16-28
26173968-1	2016	Variants in the WD repeat 45 (WDR45) gene in human Xp11.23 have recently been identified in patients suffering from neurodegeneration with brain iron accumulation, a genetically and phenotypically heterogeneous condition.	Iron	145-149	WD repeat domain 45	Homo sapiens	30-35
26173968-2	2016	WDR45 variants cause a childhood-onset encephalopathy accompanied by neurodegeneration in adulthood and iron accumulation in the basal ganglia.	Iron	104-108	WD repeat domain 45	Homo sapiens	0-5
26173968-6	2016	These findings reveal that males with WDR45 deletions are viable, and can present with early-onset epileptic encephalopathy without brain iron accumulation.	Iron	138-142	WD repeat domain 45	Homo sapiens	38-43
26782808-0	2016	Iron modulates the alpha chain of fibrinogen.	Iron	0-4	fibrinogen beta chain	Homo sapiens	34-44
26782808-1	2016	Iron-bound fibrinogen has been noted to accelerate plasmatic coagulation in patients with divergent conditions involving upregulation of heme oxygenase activity, including hemodialysis, Alzheimer"s disease, sickle cell anemia, and chronic migraine.	Iron	0-4	fibrinogen beta chain	Homo sapiens	11-21
26782808-2	2016	Our goal was to determine if a site of iron-fibrinogen interaction was on the alpha chain.	Iron	39-43	fibrinogen beta chain	Homo sapiens	44-54
26782808-5	2016	Iron enhances plasmatic coagulation kinetics by modulating the alpha chain of fibrinogen.	Iron	0-4	fibrinogen beta chain	Homo sapiens	78-88
26861925-10	2016	CONCLUSIONS: The pattern of association of TSAT and transferrin with T2D suggests that the underlying relationship between iron stores and T2D is more complex than the simple link suggested by the association of ferritin with T2D.	Iron	123-127	transferrin	Homo sapiens	52-63
26759251-4	2016	A fitting model using a linear combination of the XANES of Tf and deliquescent Fe(III) sulfate allowed to explain the near edge structure recorded for HT-29 cells indicating that cellular overload with inorganic Fe results in a non-ferritin-like fast Fe storage.	Iron	212-214	transferrin	Homo sapiens	59-61
26759251-8	2016	These Fe/S ratios were dramatically lower for HCA-7 treated with organic Fe(III) treatments suggesting dissimilarities from the Tf-like Fe uptake.	Iron	73-75	transferrin	Homo sapiens	128-130
26250435-10	2016	Serum-ferritin and transferrin saturation concentrations were also significantly increased with IV iron.	Iron	99-103	transferrin	Homo sapiens	19-30
26842892-0	2016	Protection of scaffold protein Isu from degradation by the Lon protease Pim1 as a component of Fe-S cluster biogenesis regulation.	Iron	95-99	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	72-76
26482524-2	2016	Our objective was to assess usefulness of history of RLS and pica in relation with iron stores in blood donors.	Iron	83-87	RLS1	Homo sapiens	53-56
27277369-6	2016	Percentage of transferrin saturation (TS) calculated from serum iron and TIBC.	Iron	64-68	transferrin	Homo sapiens	14-25
27120435-0	2016	Iron-refractory iron deficiency anemia (IRIDA) cases with 2 novel TMPRSS6 mutations.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	66-73
27120435-1	2016	Iron-refractory iron deficiency anemia (IRIDA) is a rarely diagnosed autosomal recessive disorder that presents with hypochromic, microcytic anemia due to mutations in TMPRSS6, which encodes matriptase-2.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	168-175
27120435-1	2016	Iron-refractory iron deficiency anemia (IRIDA) is a rarely diagnosed autosomal recessive disorder that presents with hypochromic, microcytic anemia due to mutations in TMPRSS6, which encodes matriptase-2.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	191-203
26913482-5	2016	Here, we report yet another crystal structure of the truncated hemoglobin from Arabidopsis thaliana (AHb3) with two water molecules in the heme pocket, of which one is distinctly coordinated to the heme iron, unlike the only available crystal structure of AHb3 with a hydroxyl ligand.	Iron	203-207	hemoglobin 2	Arabidopsis thaliana	63-73
26919468-10	2016	Our recent biochemical studies showed that the archael Thi4 orthologs use nicotinamide adenine dinucleotide, glycine, and free sulfide to form the thiamin thiazole in an iron-dependent reaction [Eser, B., Zhang, X., Chanani, P. K., Begley, T. P., and Ealick, S. E. (2016) J.	Iron	170-174	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	55-59
26919691-5	2016	Insertion of the iron center signals to the metallochaperones HypA, HypB, and SlyD to selectively deliver the nickel to the active site.	Iron	17-21	pre-mRNA processing factor 40 homolog A	Homo sapiens	62-66
26919468-15	2016	Here we report X-ray crystal structures of Thi4 from M. jannaschii complexed with ADP-ribulose, the C205S variant of Thi4 from S. cerevisiae with a bound glycine imine intermediate, and Thi4 from M. igneus with bound glycine imine intermediate and iron.	Iron	248-252	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	43-47
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	4-8	FIC domain protein adenylyltransferase	Homo sapiens	60-64
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	96-100	FIC domain protein adenylyltransferase	Homo sapiens	60-64
26883495-4	2016	Enhanced FE properties from the TNF sample resulted in a turn-on field as low as 0.52 V mum(-1) at a current density of 0.1 mA cm(-2) and a field enhancement factor (beta) as high as  5.16 x 10(5).	Iron	9-11	tumor necrosis factor	Homo sapiens	32-35
26797126-0	2016	Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.	Iron	63-67	circadian locomotor output cycles kaput	Mus musculus	10-15
26759376-4	2016	These inhibitors partially prevented intracellular iron provision by attenuating intracellular transport of transferrin or autophagic degradation of ferritin.	Iron	51-55	transferrin	Homo sapiens	108-119
26797126-8	2016	The time-dependent variation of cellular iron levels, and the proliferation rate in wild-type colon-26 tumor was decreased by CLOCK(Delta19)expression.	Iron	41-45	circadian locomotor output cycles kaput	Mus musculus	126-131
26978329-0	2016	Phosphorylation of Akt by SC79 Prevents Iron Accumulation and Ameliorates Early Brain Injury in a Model of Experimental Subarachnoid Hemorrhage.	Iron	40-44	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
26978329-2	2016	This study is undertaken to determine whether iron metabolism is involved in the beneficial effect of Akt activation after SAH.	Iron	46-50	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
26978329-6	2016	Interestingly, we found that phosphorylation of Akt by SC79 reduced cell surface transferrin receptor-mediated iron uptake and promoted ferroportin-mediated iron transport after SAH.	Iron	111-115	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
26978329-6	2016	Interestingly, we found that phosphorylation of Akt by SC79 reduced cell surface transferrin receptor-mediated iron uptake and promoted ferroportin-mediated iron transport after SAH.	Iron	111-115	transferrin	Rattus norvegicus	81-92
26978329-6	2016	Interestingly, we found that phosphorylation of Akt by SC79 reduced cell surface transferrin receptor-mediated iron uptake and promoted ferroportin-mediated iron transport after SAH.	Iron	157-161	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
26715163-6	2016	Iron depletion caused a significant reduction in serum ferritin, transferrin saturation, and MSNA (from 64.8 +- 13.3 to 39.2 +- 9.2 bs/100 hb, P &lt; 0.01) and a significant improvement in baroreflex-MSNA modulation.	Iron	0-4	transferrin	Homo sapiens	65-76
26955866-1	2016	Transferrin (Tf) is an essential transport protein circulating iron in the blood and delivering it to tissues.	Iron	63-67	transferrin	Homo sapiens	0-11
26955866-1	2016	Transferrin (Tf) is an essential transport protein circulating iron in the blood and delivering it to tissues.	Iron	63-67	transferrin	Homo sapiens	13-15
26999096-0	2016	Proteomic Profiling of Iron Overload-Induced Human Hepatic Cells Reveals Activation of TLR2-Mediated Inflammatory Response.	Iron	23-27	toll like receptor 2	Homo sapiens	87-91
26999096-7	2016	Meanwhile, proteomics data revealed protein level of TLR2 and IL6ST significantly increased 7 times and 2.9 times, respectively, in iron overloaded HH4 cells.	Iron	132-136	toll like receptor 2	Homo sapiens	53-57
26999096-9	2016	CONCLUSIONS: In this study, we demonstrated that iron overload induced hepatocytes triggering TLR2-mediated inflammatory response via NF-kappaB signaling pathway in HH4 cells.	Iron	49-53	toll like receptor 2	Homo sapiens	94-98
26978329-9	2016	These findings suggest that disrupted iron homeostasis could contribute to EBI and Akt activation may regulate iron metabolism to relieve iron toxicity, further protecting neurons from EBI after SAH.	Iron	111-115	AKT serine/threonine kinase 1	Rattus norvegicus	83-86
26978329-9	2016	These findings suggest that disrupted iron homeostasis could contribute to EBI and Akt activation may regulate iron metabolism to relieve iron toxicity, further protecting neurons from EBI after SAH.	Iron	111-115	AKT serine/threonine kinase 1	Rattus norvegicus	83-86
26672618-1	2016	Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that catalyzes the breakdown of heme to biliverdin, carbon monoxide, and iron.	Iron	124-128	heme oxygenase 1	Mus musculus	0-16
26855134-8	2016	These results demonstrated that Hcy up-regulated hepcidin expression through the BMP6/SMAD pathway, suggesting a novel mechanism underlying the hyperhomocysteinemia-associated perturbation of iron homeostasis.	Iron	192-196	bone morphogenetic protein 6	Homo sapiens	81-85
26616335-4	2016	Moreover, by bypassing physiologic safeguards, indiscriminate use of IV iron overwhelms transferrin, imposing stress on the reticuloendothelial system that can have long-term adverse consequences.	Iron	72-76	transferrin	Homo sapiens	88-99
26999450-2	2016	Recent improvements in our knowledge of iron metabolism have been focused on elevated non-transferrin-bound iron and labile plasma iron levels in the peritransplantation period as potential contributors to tissue toxicity and subsequent adverse transplant outcome.	Iron	40-44	transferrin	Homo sapiens	90-101
26999450-2	2016	Recent improvements in our knowledge of iron metabolism have been focused on elevated non-transferrin-bound iron and labile plasma iron levels in the peritransplantation period as potential contributors to tissue toxicity and subsequent adverse transplant outcome.	Iron	108-112	transferrin	Homo sapiens	90-101
26999450-2	2016	Recent improvements in our knowledge of iron metabolism have been focused on elevated non-transferrin-bound iron and labile plasma iron levels in the peritransplantation period as potential contributors to tissue toxicity and subsequent adverse transplant outcome.	Iron	108-112	transferrin	Homo sapiens	90-101
27186942-5	2016	Epidemiological data from the general population draw clear associations between increased transferrin saturation (and, by inference, labile iron) and early death, diabetes, and malignant transformation.	Iron	141-145	transferrin	Homo sapiens	91-102
26873465-5	2016	Results for the reference materials were in excellent agreement with recommended values, with the exception of USGS BIR-1, for which higher Fe(II) values and lower total Fe values were obtained.	Iron	140-142	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	116-121
26333155-3	2016	The objective of this research was to study As biomineralization in a minimal iron environment for the bioremediation of As-contaminated groundwater using simultaneous As(V) and SO4 (2-) reduction.	Iron	78-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	168-173
26852648-3	2016	AIM: To determine serum apelin among 40 children and adolescents with SCD compared with 40 healthy controls and assess its relation to markers of hemolysis, iron overload as well as cardiopulmonary complications.	Iron	157-161	apelin	Homo sapiens	24-30
26852655-2	2016	Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4x10(-7)), which encodes the human hemochromatosis gene.	Iron	6-10	transferrin	Homo sapiens	103-114
26672618-1	2016	Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that catalyzes the breakdown of heme to biliverdin, carbon monoxide, and iron.	Iron	124-128	heme oxygenase 1	Mus musculus	18-22
26820052-0	2016	Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases.	Iron	59-63	bone morphogenetic protein 6	Homo sapiens	0-28
26679080-7	2016	Coating NT50 with hemoglobin or transferrin significantly aggravated cytotoxicity to RPMC, with an increase in cellular catalytic ferrous iron and DNA damage also observed.	Iron	138-142	transferrin	Homo sapiens	32-43
26679080-8	2016	Knockdown of transferrin receptor with ferristatin II decreased not only NT50 uptake but also cellular catalytic ferrous iron.	Iron	121-125	transferrin	Homo sapiens	13-24
26679080-9	2016	Our results suggest that adsorption of hemoglobin and transferrin on the surface of NT50 play a role in causing mesothelial iron overload, contributing to oxidative damage and possibly subsequent carcinogenesis in mesothelial cells.	Iron	124-128	transferrin	Homo sapiens	54-65
26582087-0	2016	Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans.	Iron	97-101	bone morphogenetic protein 6	Homo sapiens	26-30
26854247-0	2016	Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells.	Iron	0-4	AKT serine/threonine kinase 1	Homo sapiens	40-43
26582087-3	2016	Iron stimulates the gene encoding hepcidin (HAMP) via the bone morphogenetic protein (BMP)6 signaling to SMAD.	Iron	0-4	bone morphogenetic protein 6	Homo sapiens	86-91
26582087-6	2016	METHODS: We sequenced the BMP6 gene in 70 consecutive patients with a moderate increase in serum ferritin and liver iron levels who did not carry genetic variants associated with hemochromatosis.	Iron	116-120	bone morphogenetic protein 6	Homo sapiens	26-30
26582087-10	2016	RESULTS: We identified 3 heterozygous missense mutations in BMP6 (p.Pro95Ser, p.Leu96Pro, and p.Gln113Glu) in 6 unrelated patients with unexplained iron overload (9% of our cohort).	Iron	148-152	bone morphogenetic protein 6	Homo sapiens	60-64
26582087-17	2016	CONCLUSIONS: We identified 3 heterozygous missense mutations in BMP6 in patients with unexplained iron overload.	Iron	98-102	bone morphogenetic protein 6	Homo sapiens	64-68
26290259-6	2016	Systemic and intracellular iron regulators of hepcidin and F-box and leucine-rich repeat protein 5 (FBXL5) expression levels were significantly suppressed in CHC patients (p=0.0032 and p=0.016, respectively) despite their significantly higher levels of serum iron and ferritin compared with controls.	Iron	27-31	F-box and leucine rich repeat protein 5	Homo sapiens	100-105
26290259-6	2016	Systemic and intracellular iron regulators of hepcidin and F-box and leucine-rich repeat protein 5 (FBXL5) expression levels were significantly suppressed in CHC patients (p=0.0032 and p=0.016, respectively) despite their significantly higher levels of serum iron and ferritin compared with controls.	Iron	259-263	F-box and leucine rich repeat protein 5	Homo sapiens	100-105
26290259-7	2016	However, intracellular iron regulators of FBXL5 and iron regulatory proteins were regulated in balance with hepatic iron deposition.	Iron	23-27	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
26290259-8	2016	Significant correlations were observed among IL-6, bone morphogenetic protein 6, hepcidin and ferroportin, as regards systemic iron regulation.	Iron	127-131	interleukin 6	Homo sapiens	45-49
26290259-8	2016	Significant correlations were observed among IL-6, bone morphogenetic protein 6, hepcidin and ferroportin, as regards systemic iron regulation.	Iron	127-131	bone morphogenetic protein 6	Homo sapiens	51-79
26290259-10	2016	Low baseline levels of the intracellular iron regulators of FBXL5 in addition to a suppressed hepcidin level might be associated with severe hepatic iron deposition in CHC patients.	Iron	41-45	F-box and leucine rich repeat protein 5	Homo sapiens	60-65
26290259-10	2016	Low baseline levels of the intracellular iron regulators of FBXL5 in addition to a suppressed hepcidin level might be associated with severe hepatic iron deposition in CHC patients.	Iron	149-153	F-box and leucine rich repeat protein 5	Homo sapiens	60-65
26791102-4	2016	In the current study, we identified a direct Nrf2 targeting miRNA, miR-214, and demonstrated a protective role of miR-214 in erythroid cells against oxidative stresses generated by radiation, excess iron and arsenic (As) exposure.	Iron	199-203	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
26791102-4	2016	In the current study, we identified a direct Nrf2 targeting miRNA, miR-214, and demonstrated a protective role of miR-214 in erythroid cells against oxidative stresses generated by radiation, excess iron and arsenic (As) exposure.	Iron	199-203	microRNA 214	Homo sapiens	114-121
26854247-7	2016	Interestingly, iron increased the activity of ERK and AKT and reduced DyrK1B.	Iron	15-19	mitogen-activated protein kinase 1	Homo sapiens	46-49
26854247-7	2016	Interestingly, iron increased the activity of ERK and AKT and reduced DyrK1B.	Iron	15-19	AKT serine/threonine kinase 1	Homo sapiens	54-57
26854247-7	2016	Interestingly, iron increased the activity of ERK and AKT and reduced DyrK1B.	Iron	15-19	dual specificity tyrosine phosphorylation regulated kinase 1B	Homo sapiens	70-76
26854247-0	2016	Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells.	Iron	0-4	mitogen-activated protein kinase 3	Homo sapiens	48-54
26854247-0	2016	Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells.	Iron	0-4	dual specificity tyrosine phosphorylation regulated kinase 1B	Homo sapiens	69-75
26930212-6	2016	Patients with MECP2 gain-of-function mutations showed increased oxidative stress marker levels (plasma non-protein bound iron, intraerythrocyte non-protein bound iron, F2-isoprostanes, and F4-neuroprostanes), as compared to healthy controls (P &lt;= 0.05).	Iron	121-125	methyl-CpG binding protein 2	Homo sapiens	14-19
26560875-0	2016	miR-20a regulates expression of the iron exporter ferroportin in lung cancer.	Iron	36-40	microRNA 20a	Homo sapiens	0-7
26560875-8	2016	Taken together, our data suggest that increased expression of miR-20 in lung cancer may decrease iron export, leading to intracellular iron retention, which, in turn, favors cell proliferation.	Iron	97-101	microRNA 20a	Homo sapiens	62-68
26560875-8	2016	Taken together, our data suggest that increased expression of miR-20 in lung cancer may decrease iron export, leading to intracellular iron retention, which, in turn, favors cell proliferation.	Iron	135-139	microRNA 20a	Homo sapiens	62-68
26930212-6	2016	Patients with MECP2 gain-of-function mutations showed increased oxidative stress marker levels (plasma non-protein bound iron, intraerythrocyte non-protein bound iron, F2-isoprostanes, and F4-neuroprostanes), as compared to healthy controls (P &lt;= 0.05).	Iron	162-166	methyl-CpG binding protein 2	Homo sapiens	14-19
27236130-6	2016	The efficacy of intravenous iron in improving hemoglobin, ferritin, and transferrin saturation is well established, and superior to oral iron, but the long-term safety of this route of administration has not been established and there are theoretical concerns that patients may be exposed to increased oxidative stress and exacerbation of infections.	Iron	28-32	transferrin	Homo sapiens	72-83
27236131-7	2016	All IV iron products are taken up into the reticuloendothelial system where the shell is metabolized and the iron is stored within tissue ferritin or exported to circulating transferrin.	Iron	7-11	transferrin	Homo sapiens	174-185
27236131-7	2016	All IV iron products are taken up into the reticuloendothelial system where the shell is metabolized and the iron is stored within tissue ferritin or exported to circulating transferrin.	Iron	109-113	transferrin	Homo sapiens	174-185
27236135-2	2016	Intestinal absorption of iron from FC results in increases in serum iron, ferritin, and transferrin saturation, effects that occur over 12 to 24 weeks and subsequently appear to plateau.	Iron	25-29	transferrin	Homo sapiens	88-99
26606902-0	2016	Luminescence turn-on/off sensing of biological iron by carbon dots in transferrin.	Iron	47-51	transferrin	Homo sapiens	70-81
26597663-7	2016	Also, the T-allele of TMPRSS6 rs855791 was negatively associated with iron stores in men.	Iron	70-74	transmembrane serine protease 6	Homo sapiens	22-29
26597663-11	2016	In addition, we showed that presence of the T-allele at rs855791 in TMPRSS6 was associated with lower iron stores in men.	Iron	102-106	transmembrane serine protease 6	Homo sapiens	68-75
26606902-10	2016	Furthermore, the results from UV-Vis and far-UV CD measurements revealed a significant conformational change of Tf at pH 3.5 relative to pH 7.4, which triggers the subsequent release of bound iron from Tf.	Iron	192-196	transferrin	Homo sapiens	112-114
26768209-7	2016	The intracranial CD91-hemopexin system was active after SAH because CD91 positively correlated with iron deposition in brain tissue.	Iron	100-104	LDL receptor related protein 1	Homo sapiens	17-21
26768209-7	2016	The intracranial CD91-hemopexin system was active after SAH because CD91 positively correlated with iron deposition in brain tissue.	Iron	100-104	LDL receptor related protein 1	Homo sapiens	68-72
26824729-6	2016	The DMT1 protein in duodenum and liver and ferroportin 1 (FPN1) protein in liver was greater (P&lt;0 05) in the MnSO4 group than in the MnLys group, and in L-Fe rats than in H-Fe rats.	Iron	158-160	solute carrier family 40 member 1	Rattus norvegicus	58-62
26606902-10	2016	Furthermore, the results from UV-Vis and far-UV CD measurements revealed a significant conformational change of Tf at pH 3.5 relative to pH 7.4, which triggers the subsequent release of bound iron from Tf.	Iron	192-196	transferrin	Homo sapiens	202-204
26606902-2	2016	In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases.	Iron	62-66	transferrin	Homo sapiens	26-37
26606902-12	2016	Our present results show that these chemically synthesized water-dispersed CDs have the ability to selectively sense the bound iron from released iron of Tf without any conformational perturbation and hence they can be used as potential biological iron sensors as well as luminescent markers for the detection of iron deficiency/overload in biological macromolecules.	Iron	127-131	transferrin	Homo sapiens	154-156
26606902-12	2016	Our present results show that these chemically synthesized water-dispersed CDs have the ability to selectively sense the bound iron from released iron of Tf without any conformational perturbation and hence they can be used as potential biological iron sensors as well as luminescent markers for the detection of iron deficiency/overload in biological macromolecules.	Iron	146-150	transferrin	Homo sapiens	154-156
26606902-12	2016	Our present results show that these chemically synthesized water-dispersed CDs have the ability to selectively sense the bound iron from released iron of Tf without any conformational perturbation and hence they can be used as potential biological iron sensors as well as luminescent markers for the detection of iron deficiency/overload in biological macromolecules.	Iron	146-150	transferrin	Homo sapiens	154-156
26606902-2	2016	In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases.	Iron	62-66	transferrin	Homo sapiens	39-41
26606902-2	2016	In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases.	Iron	85-89	transferrin	Homo sapiens	26-37
26606902-2	2016	In mammalian cells, serum transferrin (Tf) is responsible for iron transport and its iron overload/deficiency causes various diseases.	Iron	85-89	transferrin	Homo sapiens	39-41
26901220-4	2016	Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	148-152
26901220-4	2016	Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine.	Iron	0-4	bone morphogenetic protein 6	Rattus norvegicus	157-161
26901220-4	2016	Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine.	Iron	0-4	NFE2 like bZIP transcription factor 2	Rattus norvegicus	167-171
26901220-6	2016	TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues.	Iron	48-52	hepcidin antimicrobial peptide	Rattus norvegicus	43-47
26878799-0	2016	Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity.	Iron	0-4	mitogen-activated protein kinase 8	Homo sapiens	65-68
26743084-3	2016	Utilizing primary cells and cell lines (including those with no discernible expression of ferroportin on their surface), we demonstrate that upon Fe loading, the multifunctional enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is recruited to the cell surface, "treadmills" apotransferrin in and out of the cell.	Iron	146-148	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	185-225
26743084-3	2016	Utilizing primary cells and cell lines (including those with no discernible expression of ferroportin on their surface), we demonstrate that upon Fe loading, the multifunctional enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is recruited to the cell surface, "treadmills" apotransferrin in and out of the cell.	Iron	146-148	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	227-232
26743084-4	2016	Kinetic analysis utilizing labeled ligand, GAPDH-knockdown cells, (55)Fe-labeled cells and pharmacological inhibitors of endocytosis confirmed GAPDH-dependent apotransferrin internalization as a prerequisite for cellular Fe export.	Iron	70-72	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	143-148
26666535-2	2016	Iron influx to the developing erythroblast is controlled by the expression of the transferrin receptor, while iron efflux is regulated by ferroportin (FPN), the sole iron-exporting protein.	Iron	0-4	transferrin	Homo sapiens	82-93
26866805-1	2016	BACKGROUND: Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10mumol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acute vascular injury.	Iron	142-146	transferrin	Homo sapiens	124-135
26866805-1	2016	BACKGROUND: Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10mumol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acute vascular injury.	Iron	203-207	transferrin	Homo sapiens	124-135
26866805-1	2016	BACKGROUND: Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10mumol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acute vascular injury.	Iron	203-207	transferrin	Homo sapiens	124-135
26845567-5	2016	Feeding of iron-deficient diet as well as erythropoietin treatment increased TMPRSS6 protein content in rats and mice by a posttranscriptional mechanism; the increase in TMPRSS6 protein by erythropoietin was also observed in Bmp6-mutant mice.	Iron	11-15	transmembrane serine protease 6	Rattus norvegicus	77-84
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Iron	131-135	iron-sulfur cluster assembly enzyme	Homo sapiens	184-188
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Iron	131-135	heat shock protein family A (Hsp70) member 9	Homo sapiens	233-238
26677163-7	2016	Both, CAT and SOD activities were significantly increased in cortex after Fe administration over control values, without changes in striatum and hippocampus.	Iron	74-76	catalase	Rattus norvegicus	6-9
26596411-2	2016	Physiologically, the liver synthesizes transferrin, in charge of blood iron transport; ceruloplasmin, acting through its ferroxidase activity; and hepcidin, the master regulator of systemic iron.	Iron	71-75	transferrin	Homo sapiens	39-50
26612741-6	2016	FBP-ferritin binding may affect blood coagulation and influence iron metabolism, oxidative condition, angiogenesis, inflammatory condition and immune response.	Iron	64-68	ECB2	Homo sapiens	0-3
26612741-8	2016	The possible simultaneous uptake of zinc ion with FBP-ferritin complex is likely to attenuate iron- and/or heme-mediated oxidative damage and inflammatory response.	Iron	94-98	ECB2	Homo sapiens	50-53
29898328-5	2016	Adipocytic iron is involved in maintaining or worsening insulin resistance.	Iron	11-15	insulin	Homo sapiens	56-63
29898329-4	2016	Sideroblastic anemias is characterized by mitochondrial iron overload and presence of ring sideroblasts in patient bone marrow.. IRIDA results from bi-allelic mutations of TMPRSS6 gene encoding Matriptase-2.	Iron	56-60	transmembrane serine protease 6	Homo sapiens	172-179
29898329-4	2016	Sideroblastic anemias is characterized by mitochondrial iron overload and presence of ring sideroblasts in patient bone marrow.. IRIDA results from bi-allelic mutations of TMPRSS6 gene encoding Matriptase-2.	Iron	56-60	transmembrane serine protease 6	Homo sapiens	194-206
29898329-5	2016	Matriptase-2 protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis.	Iron	135-139	transmembrane serine protease 6	Homo sapiens	0-12
26989394-2	2016	The newest classification of CRS into seven etiologically and clinically distinct types for direct patient management purposes includes hemodynamic, uremic, vascular, neurohumoral, anemia- and/or iron metabolism-related, mineral metabolism-related and protein-energy wasting-related CRS.	Iron	196-200	twist family bHLH transcription factor 1	Homo sapiens	29-32
26577567-0	2016	Activation of the NLRP3 inflammasome by cellular labile iron.	Iron	56-60	NLR family pyrin domain containing 3	Homo sapiens	18-23
26577567-5	2016	Here we describe how cellular labile iron activates the NLRP3 inflammasome in human monocytes.	Iron	37-41	NLR family pyrin domain containing 3	Homo sapiens	56-61
27121523-9	2016	Activity of liver alcohol dehydrogenase was lowered in calcium supplemented group and in calcium + iron supplemented group, while that of carbonic anhydrase was significantly reduced by iron, calcium and their combination.	Iron	99-103	aldo-keto reductase family 1 member A1	Rattus norvegicus	18-39
27042462-10	2016	Effect of iron overload is potentially explained by positive correlation of blood transfusion and ferritin level with frequency of CD3+CD27- and that of ferritin with frequency of CD57+ T cells.	Iron	10-14	beta-1,3-glucuronyltransferase 1	Homo sapiens	180-184
26813504-3	2016	Low iron status plays a role in the pathophysiology of ADHR.	Iron	4-8	arginine vasopressin receptor 2	Homo sapiens	55-59
26935626-4	2016	In addition to these common etiologies, germline mutations of TMPRSS6 can cause iron-refractory IDA (IRIDA).	Iron	80-84	transmembrane serine protease 6	Homo sapiens	62-69
23606586-2	2016	Based upon the high levels of iron-saturated transferrin in plasma serum, it was hypothesized that terminal differentiation in serum-free media may be highly dependent on the concentration of iron.	Iron	30-34	transferrin	Homo sapiens	45-56
23606586-2	2016	Based upon the high levels of iron-saturated transferrin in plasma serum, it was hypothesized that terminal differentiation in serum-free media may be highly dependent on the concentration of iron.	Iron	192-196	transferrin	Homo sapiens	45-56
23606586-3	2016	Here adult human CD34(+) cells were cultured in a serum-free medium containing dosed levels of iron-saturated transferrin (holo-Tf, 0.1-1.0 mg/ml).	Iron	95-99	transferrin	Homo sapiens	110-121
26746433-10	2016	Furthermore, a heterozygous variation in the iron-related transmembrane protease serine 6 (TMPRSS6) gene, rs855791 was found, which could have impacted the patient"s iron status following two successive blood donations and exposure to malaria preceding the MS diagnosis.	Iron	45-49	transmembrane serine protease 6	Homo sapiens	58-89
26746433-10	2016	Furthermore, a heterozygous variation in the iron-related transmembrane protease serine 6 (TMPRSS6) gene, rs855791 was found, which could have impacted the patient"s iron status following two successive blood donations and exposure to malaria preceding the MS diagnosis.	Iron	45-49	transmembrane serine protease 6	Homo sapiens	91-98
26746433-10	2016	Furthermore, a heterozygous variation in the iron-related transmembrane protease serine 6 (TMPRSS6) gene, rs855791 was found, which could have impacted the patient"s iron status following two successive blood donations and exposure to malaria preceding the MS diagnosis.	Iron	166-170	transmembrane serine protease 6	Homo sapiens	58-89
26746433-10	2016	Furthermore, a heterozygous variation in the iron-related transmembrane protease serine 6 (TMPRSS6) gene, rs855791 was found, which could have impacted the patient"s iron status following two successive blood donations and exposure to malaria preceding the MS diagnosis.	Iron	166-170	transmembrane serine protease 6	Homo sapiens	91-98
26790960-1	2016	Mutations in the WDR45 gene have been identified as causative for the only X-linked type of neurodegeneration with brain iron accumulation (NBIA), clinically characterized by global developmental delay in childhood, followed by a secondary neurological decline with parkinsonism and/or dementia in adolescence or early adulthood.	Iron	121-125	WD repeat domain 45	Homo sapiens	17-22
26644507-5	2016	In addition, FCR activity and expression of Fe acquisition-related genes were higher in the Suc high-accumulating transgenic plant 35S::SUC2 but were lower in the Suc low-accumulating mutant suc2-5 compared with wild-type plants under Fe-deficient conditions.	Iron	44-46	sucrose-proton symporter 2	Arabidopsis thaliana	136-140
26644507-5	2016	In addition, FCR activity and expression of Fe acquisition-related genes were higher in the Suc high-accumulating transgenic plant 35S::SUC2 but were lower in the Suc low-accumulating mutant suc2-5 compared with wild-type plants under Fe-deficient conditions.	Iron	44-46	sucrose-proton symporter 2	Arabidopsis thaliana	191-195
26644507-5	2016	In addition, FCR activity and expression of Fe acquisition-related genes were higher in the Suc high-accumulating transgenic plant 35S::SUC2 but were lower in the Suc low-accumulating mutant suc2-5 compared with wild-type plants under Fe-deficient conditions.	Iron	235-237	sucrose-proton symporter 2	Arabidopsis thaliana	191-195
26935626-6	2016	Functional loss of matriptase-2 due to homozygous mutations results in an increase in the expression of hepcidin, which is the key regulator of systemic iron homeostasis.	Iron	153-157	transmembrane serine protease 6	Homo sapiens	19-31
26818499-0	2016	Regulation of ATP13A2 via PHD2-HIF1alpha Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson"s Disease.	Iron	76-80	egl-9 family hypoxia inducible factor 1	Homo sapiens	26-30
26893541-9	2016	Both L1 and DF could also prevent iron absorption.	Iron	34-38	immunoglobulin kappa variable 1-16	Homo sapiens	5-14
26839325-0	2016	Quantification of Hepcidin-related Iron Accumulation in the Rat Liver.	Iron	35-39	hepcidin antimicrobial peptide	Rattus norvegicus	18-26
26839325-1	2016	Hepcidin was originally detected as a liver peptide with antimicrobial activity and it functions as a central regulator in the systemic iron metabolism.	Iron	136-140	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
26839325-2	2016	Consequently suppression of hepcidin leads to iron accumulation in the liver.	Iron	46-50	hepcidin antimicrobial peptide	Rattus norvegicus	28-36
26839325-3	2016	AbbVie developed a monoclonal antibody ([mAb]; repulsive guidance molecule [RGMa/c] mAb) that downregulates hepcidin expression by influencing the RGMc/bone morphogenetic protein (BMP)/neogenin receptor complex and causes iron deposition in the liver.	Iron	222-226	hepcidin antimicrobial peptide	Rattus norvegicus	108-116
26818499-0	2016	Regulation of ATP13A2 via PHD2-HIF1alpha Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson"s Disease.	Iron	76-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-40
26818499-3	2016	HIF1alpha itself induces the transcription of various cellular stress genes, including several involved in iron metabolism.	Iron	107-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
26818499-8	2016	These data suggest that regulation of ATP13A2 by the PHD2-HIF1alpha signaling pathway affects cellular iron homeostasis and DAergic neuronal survival.	Iron	103-107	egl-9 family hypoxia inducible factor 1	Homo sapiens	53-57
26818499-8	2016	These data suggest that regulation of ATP13A2 by the PHD2-HIF1alpha signaling pathway affects cellular iron homeostasis and DAergic neuronal survival.	Iron	103-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-67
26818499-12	2016	Knockdown of ATP13A2, a gene linked to a rare juvenile form of Parkinson"s disease and recently identified as a novel HIF1alpha target, was found to abrogate maintenance of cellular iron homeostasis and neuronal viability elicited by PHD2 inhibition in vivo and in cultured dopaminergic cells under conditions of mitochondrial stress.	Iron	182-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-127
26808690-8	2016	Compared to the WT mice, alcohol feeding of ALR-deficient mice resulted in significantly greater increase in hepatic TNFalpha and TGFbeta, and oxidative stress; there was also hepatic iron accumulation, robust lipid peroxidation and mitochondrial DNA damage.	Iron	184-188	growth factor, augmenter of liver regeneration	Mus musculus	44-47
26808690-9	2016	Importantly, similar to ALR-deficient mice, lower hepatic ALR levels in human alcoholic liver cirrhosis were associated with increased iron content, reduced expression of alcohol dehydrogenase and acetaldehyde dehydrogenase, and elevated fibrogenic markers.	Iron	135-139	growth factor, augmenter of liver regeneration	Mus musculus	58-61
26517689-0	2016	Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy.	Iron	53-57	tumor protein p53	Homo sapiens	6-9
26405810-5	2016	Alternately, when activated by base ((t)BuOK), 1 undergoes desulfurization to form a cyclometalated species, [((O )C(NH)NC(Ph))Fe(CO)2] (5); derivatization of 5 with PPh3 affords the structurally characterized species [((O )C(NH)NC)Fe(CO)(PPh3)2] (6), indicating complex 6 as the common intermediate along each pathway of desulfurization.	Iron	127-129	caveolin 1	Homo sapiens	166-170
26405810-5	2016	Alternately, when activated by base ((t)BuOK), 1 undergoes desulfurization to form a cyclometalated species, [((O )C(NH)NC(Ph))Fe(CO)2] (5); derivatization of 5 with PPh3 affords the structurally characterized species [((O )C(NH)NC)Fe(CO)(PPh3)2] (6), indicating complex 6 as the common intermediate along each pathway of desulfurization.	Iron	127-129	caveolin 1	Homo sapiens	239-243
26368802-0	2016	Mechanism of Co(II) adsorption by zero valent iron/graphene nanocomposite.	Iron	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
26771619-2	2016	Synthetic low-molecular weight inhibitors of matriptase-2 have potential as therapeutics to treat iron overload syndromes, in particular in patients with beta-thalassemia.	Iron	98-102	transmembrane serine protease 6	Homo sapiens	45-57
27141409-2	2016	Mutations in PLA2G6 are associated with a number of neurodegenerative disorders including neurodegeneration with brain iron accumulation (NBIA), infantile neuroaxonal dystrophy (INAD), and dystonia parkinsonism, collectively known as PLA2G6-associated neurodegeneration (PLAN).	Iron	119-123	phospholipase A2 group VI	Homo sapiens	13-19
26564716-9	2016	In addition, RAW 264.7 macrophages loaded with exogenous iron showed significantly higher levels of inflammatory markers (Inos, Tnfalpha, Mcp1, Tlr4).	Iron	57-61	tumor necrosis factor	Mus musculus	128-136
26564716-9	2016	In addition, RAW 264.7 macrophages loaded with exogenous iron showed significantly higher levels of inflammatory markers (Inos, Tnfalpha, Mcp1, Tlr4).	Iron	57-61	mast cell protease 1	Mus musculus	138-142
26564716-9	2016	In addition, RAW 264.7 macrophages loaded with exogenous iron showed significantly higher levels of inflammatory markers (Inos, Tnfalpha, Mcp1, Tlr4).	Iron	57-61	toll-like receptor 4	Mus musculus	144-148
26517689-7	2016	Altogether, targeting BNIP3L in wild-type p53 colon cancer cells is a novel anticancer strategy activating iron depletion signaling and the mitophagy-related cell death pathway.	Iron	107-111	tumor protein p53	Homo sapiens	42-45
26778957-0	2015	Mice Overexpressing Both Non-Mutated Human SOD1 and Mutated SOD1(G93A) Genes: A Competent Experimental Model for Studying Iron Metabolism in Amyotrophic Lateral Sclerosis.	Iron	122-126	superoxide dismutase 1	Homo sapiens	60-64
26792697-14	2016	Moreover, mRNA expression of phosphatidylinositol-3-kinase (PI3K) gene involved in oxidative stress signaling pathway in the iron overload group was up-regulated, while fork head protein O3 (FOXO3) which regulated oxidative stress through negative feedback showed a down-regulation level of mRNA expression compared with the control group.	Iron	125-129	forkhead box O3	Homo sapiens	191-196
26761004-4	2016	Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.	Iron	26-29	nitric oxide synthase 2, inducible	Mus musculus	142-146
26778957-4	2015	Of importance, both ALS patients and animals carrying mutated human SOD1 gene show symptoms of oxidative stress and iron metabolism misregulation.	Iron	116-120	superoxide dismutase 1	Homo sapiens	68-72
26778957-5	2015	The aim of our study was to characterize changes in iron metabolism in one of the most commonly used models of ALS - transgenic mice overexpressing human mutated SOD1(G93A) gene.	Iron	52-56	superoxide dismutase 1	Homo sapiens	162-166
26778957-6	2015	We analyzed the expression of iron-related genes in asymptomatic, 2-month-old and symptomatic, 4-month-old SOD1(G93A) mice.	Iron	30-34	superoxide dismutase 1, soluble	Mus musculus	107-111
26778957-8	2015	We demonstrate that the overexpression of both SOD1 and SOD1(G93A) genes account for a substantial increase in SOD1 protein levels and activity in selected tissues and that not all the changes in iron metabolism genes expression are specific for the overexpression of the mutated form of SOD1.	Iron	196-200	superoxide dismutase 1	Homo sapiens	47-51
26778957-8	2015	We demonstrate that the overexpression of both SOD1 and SOD1(G93A) genes account for a substantial increase in SOD1 protein levels and activity in selected tissues and that not all the changes in iron metabolism genes expression are specific for the overexpression of the mutated form of SOD1.	Iron	196-200	superoxide dismutase 1	Homo sapiens	56-60
26778957-8	2015	We demonstrate that the overexpression of both SOD1 and SOD1(G93A) genes account for a substantial increase in SOD1 protein levels and activity in selected tissues and that not all the changes in iron metabolism genes expression are specific for the overexpression of the mutated form of SOD1.	Iron	196-200	superoxide dismutase 1	Homo sapiens	56-60
26778957-8	2015	We demonstrate that the overexpression of both SOD1 and SOD1(G93A) genes account for a substantial increase in SOD1 protein levels and activity in selected tissues and that not all the changes in iron metabolism genes expression are specific for the overexpression of the mutated form of SOD1.	Iron	196-200	superoxide dismutase 1	Homo sapiens	56-60
27382488-2	2016	Iron depletion was defined as follows: (1) SF &lt; 15 mug/L regardless of the C-reactive protein (CRP) level and (2) SF &lt; 15 or &lt;50 mug/L with CRP &lt;= 5 or &gt;5 mg/L, respectively.	Iron	0-4	C-reactive protein	Homo sapiens	149-152
27346617-0	2016	Transferrin Saturation: A Body Iron Biomarker.	Iron	31-35	transferrin	Homo sapiens	0-11
27346617-3	2016	Among these is plasma transferrin, which is central to iron metabolism not only through iron transport between body tissues in a soluble nontoxic form but also through its protective scavenger role in sequestering free toxic iron.	Iron	55-59	transferrin	Homo sapiens	22-33
27346617-3	2016	Among these is plasma transferrin, which is central to iron metabolism not only through iron transport between body tissues in a soluble nontoxic form but also through its protective scavenger role in sequestering free toxic iron.	Iron	88-92	transferrin	Homo sapiens	22-33
27346617-3	2016	Among these is plasma transferrin, which is central to iron metabolism not only through iron transport between body tissues in a soluble nontoxic form but also through its protective scavenger role in sequestering free toxic iron.	Iron	88-92	transferrin	Homo sapiens	22-33
27346617-4	2016	The transferrin saturation (TSAT), an index that takes into account both plasma iron and its main transport protein, is considered an important biochemical marker of body iron status.	Iron	80-84	transferrin	Homo sapiens	4-15
27346617-4	2016	The transferrin saturation (TSAT), an index that takes into account both plasma iron and its main transport protein, is considered an important biochemical marker of body iron status.	Iron	171-175	transferrin	Homo sapiens	4-15
27771699-0	2016	Cardiac Hepcidin Expression Associates with Injury Independent of Iron.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	8-16
27771699-1	2016	BACKGROUND: Hepcidin regulates systemic iron homeostasis by downregulating the iron exporter ferroportin.	Iron	40-44	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
27771699-1	2016	BACKGROUND: Hepcidin regulates systemic iron homeostasis by downregulating the iron exporter ferroportin.	Iron	79-83	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
27771699-4	2016	We hypothesized that cardiac hepcidin gene expression is induced by and regulated to severity of cardiac injury, either through direct (MI) or remote (CKD) stimuli, as well as through increased local iron content.	Iron	200-204	hepcidin antimicrobial peptide	Rattus norvegicus	29-37
26463963-3	2016	Lipocalin 2 (LCN-2) is a siderophore-binding protein that mediates transferrin-independent iron transport.	Iron	91-95	transferrin	Rattus norvegicus	67-78
26463975-12	2016	Iron-handling protein levels in the brain, including ceruloplasmin and transferrin, were reduced in the minocycline co-injected animals.	Iron	0-4	transferrin	Rattus norvegicus	71-82
26408108-5	2016	No single test is diagnostic of ID unless the serum ferritin is low or the percent transferrin saturation is low with an elevated total iron binding capacity.	Iron	136-140	transferrin	Homo sapiens	83-94
26342303-5	2016	According to the new guidelines, when transferrin saturation is lower than 30% and ferritin lower than 500 ng/mL, a trial with iron should be started, to avoid therapy with ESAs or at least to reduce the doses needed to treat the anemia.	Iron	127-131	transferrin	Homo sapiens	38-49
27642598-2	2016	Dysfunction of matriptase-2 can be involved in iron regulatory disorder via downregulation of hepcidin expression.	Iron	47-51	transmembrane serine protease 6	Homo sapiens	15-27
26077874-2	2016	This study aimed to determine the effect of iron supplementation in combination with docosahexaenoic acid (DHA) on the cardiovascular disease risk based on paraoxonase-1 (PON-1), high-sensitivity C-reactive protein (hs-CRP), and ApoB/ApoA-I ratio in women with IDA.	Iron	44-48	paraoxonase 1	Homo sapiens	156-169
26077874-2	2016	This study aimed to determine the effect of iron supplementation in combination with docosahexaenoic acid (DHA) on the cardiovascular disease risk based on paraoxonase-1 (PON-1), high-sensitivity C-reactive protein (hs-CRP), and ApoB/ApoA-I ratio in women with IDA.	Iron	44-48	paraoxonase 1	Homo sapiens	171-176
26077874-2	2016	This study aimed to determine the effect of iron supplementation in combination with docosahexaenoic acid (DHA) on the cardiovascular disease risk based on paraoxonase-1 (PON-1), high-sensitivity C-reactive protein (hs-CRP), and ApoB/ApoA-I ratio in women with IDA.	Iron	44-48	apolipoprotein B	Homo sapiens	229-233
26077874-2	2016	This study aimed to determine the effect of iron supplementation in combination with docosahexaenoic acid (DHA) on the cardiovascular disease risk based on paraoxonase-1 (PON-1), high-sensitivity C-reactive protein (hs-CRP), and ApoB/ApoA-I ratio in women with IDA.	Iron	44-48	apolipoprotein A1	Homo sapiens	234-240
27170390-8	2016	Considering the fact that an increased saturation of transferrin and high iron in plasma are the hallmark of all hemochromatosis forms, an alternative view would be that toxic iron in the circulation is involved in the pathogenesis of hemochromatosis.	Iron	176-180	transferrin	Homo sapiens	53-64
26074023-5	2016	Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1.	Iron	102-106	superoxide dismutase 3	Homo sapiens	170-176
26370847-4	2016	Duodenal cytochrome b and divalent metal transporter 1, involved in apical iron uptake, are 8- and 10-fold, respectively, more abundant in the duodenum of germ-free (GF) mice than in mice colonized with a microbiota.	Iron	75-79	cytochrome b reductase 1	Mus musculus	0-21
29421281-1	2016	Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes.	Iron	0-4	transferrin	Homo sapiens	91-102
29421281-1	2016	Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes.	Iron	0-4	transferrin	Homo sapiens	104-106
29421281-1	2016	Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes.	Iron	202-206	transferrin	Homo sapiens	91-102
29421281-1	2016	Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes.	Iron	202-206	transferrin	Homo sapiens	104-106
27997888-2	2016	RASD1 regulates various signaling pathways involved in iron homeostasis, growth hormone secretion, and circadian rhythm.	Iron	55-59	RAS, dexamethasone-induced 1	Mus musculus	0-5
25958740-1	2016	BACKGROUND: Haptoglobin (Hp) is one of the acute phase proteins, whose main function is to bind free haemoglobin (Hb) and transport it to the liver for degradation and iron recycling.	Iron	168-172	haptoglobin	Homo sapiens	12-23
27829333-12	2016	CONCLUSION: Iron overload can affect humeral and cell mediated immunity in patients with beta thalassemia with reduction of IgM, CD3 and CD4 and elevation of CD8, IgG, and IgA.	Iron	12-16	CD4 molecule	Homo sapiens	137-140
27170390-9	2016	Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation.	Iron	69-73	transferrin	Homo sapiens	111-122
26582371-0	2016	Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain.	Iron	48-52	hepcidin antimicrobial peptide	Rattus norvegicus	30-38
27516188-0	2016	Iron Overload Causes Alterations of E-Cadherin in the Liver.	Iron	0-4	cadherin 1	Mus musculus	36-46
26582371-1	2016	Our recent investigation showed that hepcidin can reduce iron in the brain of iron-overloaded rat by down-regulating iron-transport proteins.	Iron	57-61	hepcidin antimicrobial peptide	Rattus norvegicus	37-45
26582371-1	2016	Our recent investigation showed that hepcidin can reduce iron in the brain of iron-overloaded rat by down-regulating iron-transport proteins.	Iron	78-82	hepcidin antimicrobial peptide	Rattus norvegicus	37-45
26582371-3	2016	We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats.	Iron	54-58	hepcidin antimicrobial peptide	Rattus norvegicus	31-39
26582371-3	2016	We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats.	Iron	88-92	hepcidin antimicrobial peptide	Rattus norvegicus	31-39
26582371-3	2016	We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats.	Iron	88-92	hepcidin antimicrobial peptide	Rattus norvegicus	31-39
26582371-4	2016	To test this hypothesis, we investigated the effects of pre-treatment of rats with recombinant-hepcidin-adenovirus (ad-hepcidin) on the contents of iron, dichlorofluorescein and 8-isoprostane in the brain.	Iron	148-152	hepcidin antimicrobial peptide	Rattus norvegicus	95-103
26582371-10	2016	We concluded that pre-treatment with ad-hepcidin could increase hepcidin expression and prevent the increase in iron and reduce reactive oxygen species in the brain of iron-overloaded rats.	Iron	112-116	hepcidin antimicrobial peptide	Rattus norvegicus	40-48
26582371-10	2016	We concluded that pre-treatment with ad-hepcidin could increase hepcidin expression and prevent the increase in iron and reduce reactive oxygen species in the brain of iron-overloaded rats.	Iron	168-172	hepcidin antimicrobial peptide	Rattus norvegicus	40-48
26611621-8	2016	A western blot analysis revealed that iron feeding decreased total insulin receptor substrate 1 (IRS1), phosphorylated IRS1ser307, and AS160 but increased phosphorylated GSK-3beta.	Iron	38-42	insulin receptor substrate 1	Rattus norvegicus	67-95
26611621-8	2016	A western blot analysis revealed that iron feeding decreased total insulin receptor substrate 1 (IRS1), phosphorylated IRS1ser307, and AS160 but increased phosphorylated GSK-3beta.	Iron	38-42	insulin receptor substrate 1	Rattus norvegicus	97-101
26611621-8	2016	A western blot analysis revealed that iron feeding decreased total insulin receptor substrate 1 (IRS1), phosphorylated IRS1ser307, and AS160 but increased phosphorylated GSK-3beta.	Iron	38-42	insulin receptor substrate 1	Rattus norvegicus	119-123
26611621-9	2016	Iron supplementation inhibited the nuclear translocation of AKT but promoted FOXO1 translocation to nuclei.	Iron	0-4	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
27516188-8	2016	Treatment of the 115 kDa E-cad with deferoxamine, an iron chelator, thus removing Fe2+, shifted the molecular mass back to 125 kDa, demonstrating that the shift is reversible.	Iron	53-57	cadherin 1	Mus musculus	25-30
27516188-11	2016	The alteration of E-cad that causes the mobility shift might be an initial step to liver diseases by iron overload.	Iron	101-105	cadherin 1	Mus musculus	18-23
27558512-8	2016	Iron solubility and acellular hydroxyl radical generation depend on the physical properties of the NPs, especially crystalline diameter; however, these properties are weakly linked to the activation of cellular signaling of Nrf2 and the expression of oxidative stress markers.	Iron	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	224-228
27516188-4	2016	We found in liver samples from iron-overloaded mice that the apparent molecular mass of E-cad was reduced from 125 to 115 kDa in sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and immunoblotting, and that the cellular expression of E-cad was decreased in immunohistochemistry.	Iron	31-35	cadherin 1	Mus musculus	88-93
27516188-4	2016	We found in liver samples from iron-overloaded mice that the apparent molecular mass of E-cad was reduced from 125 to 115 kDa in sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and immunoblotting, and that the cellular expression of E-cad was decreased in immunohistochemistry.	Iron	31-35	cadherin 1	Mus musculus	270-275
26385212-10	2016	Increased transferrin saturation, but not ferritin, was a good indicator of the presence of forms of circulating non-transferrin-bound iron.	Iron	135-139	transferrin	Homo sapiens	10-21
27861481-5	2016	Lactoferrin is a protein member of the transferrin family of iron-binding proteins, present inside polymorphonuclear granular structure, and has been reported to affect growth and development of infectious agents, including fungal organisms.	Iron	61-65	transferrin	Homo sapiens	39-50
26385212-0	2016	Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disorders.	Iron	87-91	transferrin	Homo sapiens	69-80
26385212-1	2016	Non-transferrin-bound iron and its labile (redox active) plasma iron component are thought to be potentially toxic forms of iron originally identified in the serum of patients with iron overload.	Iron	22-26	transferrin	Homo sapiens	4-15
26385212-10	2016	Increased transferrin saturation, but not ferritin, was a good indicator of the presence of forms of circulating non-transferrin-bound iron.	Iron	135-139	transferrin	Homo sapiens	117-128
26385212-6	2016	Absolute levels differed considerably between assays and were lower for labile plasma iron than for non-transferrin-bound iron.	Iron	122-126	transferrin	Homo sapiens	104-115
26385212-9	2016	Assays correlated and correlations were highest within the group of non-transferrin-bound iron assays and within that of labile plasma iron assays.	Iron	90-94	transferrin	Homo sapiens	72-83
26524217-10	2016	The general unavailability of erythropoietin limited effective intervention for the non-iron-deficient anaemic patients.	Iron	88-92	erythropoietin	Homo sapiens	30-44
26288192-8	2016	GSTM1 null genotype was the only predictor for cardiac iron overload (P = 0.002).	Iron	55-59	glutathione S-transferase mu 1	Homo sapiens	0-5
26288192-11	2016	CONCLUSION: GSTM1 null genotype is significantly associated with cardiac iron overload independent of serum ferritin in Egyptian patients with beta-TM.	Iron	73-77	glutathione S-transferase mu 1	Homo sapiens	12-17
27110594-1	2016	The cardioprotective inducible enzyme heme oxygenase-1 (HO-1) degrades prooxidant heme into equimolar quantities of carbon monoxide, biliverdin, and iron.	Iron	149-153	heme oxygenase 1	Mus musculus	38-54
25858758-10	2016	Both PM10 and iron activated the stress kinases ERK1/2 pathway, involved in the induction of TF expression.	Iron	14-18	mitogen-activated protein kinase 3	Homo sapiens	48-54
27180706-8	2016	Iron incorporation into hemoglobin and scavenging by transferrin may buffer iron toxicity more effectively in White than in Black individuals.	Iron	0-4	transferrin	Homo sapiens	53-64
27180706-8	2016	Iron incorporation into hemoglobin and scavenging by transferrin may buffer iron toxicity more effectively in White than in Black individuals.	Iron	76-80	transferrin	Homo sapiens	53-64
26890748-0	2016	Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes.	Iron	0-4	apolipoprotein E	Homo sapiens	15-31
26890748-4	2016	OBJECTIVE: This study aimed to investigate the relationship between exogenous iron levels and ApoE in neurons and astrocytes.	Iron	78-82	apolipoprotein E	Homo sapiens	94-98
26890748-5	2016	METHODS: Our study used primary cultured cortical neurons and astrocytes to investigate the changes in ApoE caused by iron.	Iron	118-122	apolipoprotein E	Homo sapiens	103-107
26890748-7	2016	RESULTS: We observed that iron upregulated intracellular ApoE levels in both neurons and astrocytes at the post-transcriptional and transcriptional level, respectively.	Iron	26-30	apolipoprotein E	Homo sapiens	57-61
26890748-8	2016	However, there was less full-length ApoE secreted by neurons and astrocytes after iron treatment.	Iron	82-86	apolipoprotein E	Homo sapiens	36-40
26890748-10	2016	In terms of ApoE receptors, we observed that neuronal LRP-1 levels were increased by the addition of exogenous iron, which could contribute to AbetaPP endocytosis in neurons.	Iron	111-115	apolipoprotein E	Homo sapiens	12-16
26890748-10	2016	In terms of ApoE receptors, we observed that neuronal LRP-1 levels were increased by the addition of exogenous iron, which could contribute to AbetaPP endocytosis in neurons.	Iron	111-115	LDL receptor related protein 1	Homo sapiens	54-59
26890748-12	2016	CONCLUSION: Our study reveals that iron may contribute to the pathogenesis of AD by affecting ApoE and its receptors and supports the notion that iron chelation should be investigated as a therapeutic strategy for AD.	Iron	35-39	apolipoprotein E	Homo sapiens	94-98
26100117-5	2016	We observed that the K101Q mutation (due to c. 301 A&gt;C mutation) may prevent the binding of [Fe-S] to GLRX5 protein, while L148S (due to c. 443 T&gt;C mutation) may interfere with [Fe-S] transfer from GLRX5 to iron regulatory protein 1 (IRP1), mitochondrial aconitase (m-aconitase) and ferrochelatase.	Iron	96-100	aconitase 2	Homo sapiens	247-270
26535997-3	2016	In wild-type mice, acute inflammation induced by single injections of heat-killed Brucella abortus or interleukin-1beta (IL-1beta) decreased serum iron within 6 h, and was accompanied by significant increases in osseous Fgf23 mRNA expression and serum levels of C-terminal FGF23, but no changes in intact FGF23.	Iron	147-151	interleukin 1 beta	Mus musculus	121-129
26535997-4	2016	Chronic inflammation induced by repeated bacteria or IL-1beta injections decreased serum iron, increased osseous Fgf23 mRNA, and serum C-terminal FGF23, but modestly increased biologically active, intact FGF23 serum levels.	Iron	89-93	interleukin 1 beta	Mus musculus	53-61
27110594-1	2016	The cardioprotective inducible enzyme heme oxygenase-1 (HO-1) degrades prooxidant heme into equimolar quantities of carbon monoxide, biliverdin, and iron.	Iron	149-153	heme oxygenase 1	Mus musculus	56-60
26725908-2	2016	Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non-transferrin-bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the parenchymatous organs.	Iron	7-11	transferrin	Homo sapiens	121-132
26725908-2	2016	Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non-transferrin-bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the parenchymatous organs.	Iron	7-11	transferrin	Homo sapiens	151-162
26725908-2	2016	Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non-transferrin-bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the parenchymatous organs.	Iron	194-198	transferrin	Homo sapiens	151-162
25059838-6	2016	EPO was ~ 14-17 mIU mL(-1) lower (P &lt; 0.0001) in late pregnancy in groups receiving iron vs. the control group, with no difference in the FA-only group.	Iron	87-91	erythropoietin	Homo sapiens	0-3
26763345-4	2016	Deletion of MRS3, a component of the iron import machinery, also causes a copper-dependent growth defect on non-fermentable carbon.	Iron	37-41	Fe(2+) transporter	Saccharomyces cerevisiae S288C	12-16
25059838-8	2016	EPO was most strongly associated with iron status indicators in groups that did not receive iron, and in the non-iron groups cortisol was positively correlated with EPO (r = 0.15, P &lt; 0.01) and soluble transferrin receptor (sTfR, r = 0.19, P &lt; 0.001).	Iron	38-42	erythropoietin	Homo sapiens	0-3
26933479-1	2016	BACKGROUND A hypothesis has been presented about the role of serum iron, ferritin and transferrin saturation among patients with non-alcoholic fatty liver disease (NAFLD) and resistance to insulin (metabolic syndrome [MetS]), but there is much controversy.	Iron	67-71	insulin	Homo sapiens	189-196
26987842-3	2016	Iron status was determined by a combination of several indicators: ferritin, transferrin, blood count, total iron binding capacity, transferrin saturation, and C-reactive protein.	Iron	0-4	transferrin	Homo sapiens	77-88
26987842-3	2016	Iron status was determined by a combination of several indicators: ferritin, transferrin, blood count, total iron binding capacity, transferrin saturation, and C-reactive protein.	Iron	0-4	transferrin	Homo sapiens	132-143
26987842-3	2016	Iron status was determined by a combination of several indicators: ferritin, transferrin, blood count, total iron binding capacity, transferrin saturation, and C-reactive protein.	Iron	0-4	C-reactive protein	Homo sapiens	160-178
26702583-0	2016	Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.	Iron	69-73	heat shock protein family A (Hsp70) member 9	Homo sapiens	14-19
26763345-7	2016	When expressed in Lactococcus lactis, Mrs3 mediated copper and iron import.	Iron	63-67	Fe(2+) transporter	Saccharomyces cerevisiae S288C	38-42
27960647-1	2016	Congenital dyserythropoietic anemia type I (CDA I) is associated, as other anemic noninflammatory states, with ineffective erythropoiesis and increased iron absorption, which may lead to complication of iron overload.	Iron	152-156	codanin 1	Homo sapiens	0-42
27960647-1	2016	Congenital dyserythropoietic anemia type I (CDA I) is associated, as other anemic noninflammatory states, with ineffective erythropoiesis and increased iron absorption, which may lead to complication of iron overload.	Iron	203-207	codanin 1	Homo sapiens	0-42
27960647-1	2016	Congenital dyserythropoietic anemia type I (CDA I) is associated, as other anemic noninflammatory states, with ineffective erythropoiesis and increased iron absorption, which may lead to complication of iron overload.	Iron	152-156	codanin 1	Homo sapiens	44-49
27960647-1	2016	Congenital dyserythropoietic anemia type I (CDA I) is associated, as other anemic noninflammatory states, with ineffective erythropoiesis and increased iron absorption, which may lead to complication of iron overload.	Iron	203-207	codanin 1	Homo sapiens	44-49
27960647-4	2016	The purpose of this study was to examine whether treatment with proton pump inhibitors (PPIs) can decrease iron absorption in patients with CDA I.	Iron	107-111	codanin 1	Homo sapiens	140-145
26672975-0	2015	Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway.	Iron	93-97	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	25-65
27960647-11	2016	Our investigation suggests that administration of PPI to patients with CDA I may reduce iron absorption and may lower iron overload and the need for chelation therapy.	Iron	88-92	codanin 1	Homo sapiens	71-76
27960647-11	2016	Our investigation suggests that administration of PPI to patients with CDA I may reduce iron absorption and may lower iron overload and the need for chelation therapy.	Iron	118-122	codanin 1	Homo sapiens	71-76
26578707-7	2016	However, the FCR activity and the expression of genes related to Fe uptake were still up-regulated under -Fe+Put treatment compared with -Fe treatment in xth31, and Put-induced cell wall Fe remobilization was abolished in noa1 and nia1nia2, indicating that Put-regulated cell wall Fe reutilization is dependent on NO.	Iron	106-108	nitrate reductase 1	Arabidopsis thaliana	231-239
26578707-7	2016	However, the FCR activity and the expression of genes related to Fe uptake were still up-regulated under -Fe+Put treatment compared with -Fe treatment in xth31, and Put-induced cell wall Fe remobilization was abolished in noa1 and nia1nia2, indicating that Put-regulated cell wall Fe reutilization is dependent on NO.	Iron	106-108	nitrate reductase 1	Arabidopsis thaliana	231-239
26578707-7	2016	However, the FCR activity and the expression of genes related to Fe uptake were still up-regulated under -Fe+Put treatment compared with -Fe treatment in xth31, and Put-induced cell wall Fe remobilization was abolished in noa1 and nia1nia2, indicating that Put-regulated cell wall Fe reutilization is dependent on NO.	Iron	106-108	nitrate reductase 1	Arabidopsis thaliana	231-239
27458626-2	2016	Enhanced hepcidin production mainly stimulated by excess interleukin-6 levels is a key pathodgentic component of ACD (frequently known as anemia of inflammation) by causing the degradation of the transmembrane protein ferroportin, hepcidin impairs iron metabolism.	Iron	248-252	interleukin 6	Homo sapiens	57-70
26599206-4	2015	Herein, we conjugated the Hsp70-specific antibody (cmHsp70.1) which is known to recognize mHsp70 to superparamagnetic iron nanoparticles to assess tumor-specific targeting before and after ionizing irradiation.	Iron	118-122	heat shock protein 1B	Mus musculus	52-58
26563745-0	2015	Iron-Carbonyl Aqueous Vesicles (MCsomes) by Hydration of [Fe(CO){CO(CH2)5CH3}(Cp)(PPh3)] (FpC6): Highly Integrated Colloids with Aggregation-Induced Self-Enhanced IR Absorption (AI-SEIRA).	Iron	0-4	caveolin 1	Homo sapiens	82-86
26720797-14	2016	Finally, hippocampal IL-6 levels were higher in mice receiving combined radiations compared with mice receiving (56)Fe radiation alone.	Iron	116-118	interleukin 6	Mus musculus	21-25
26915864-3	2016	Functional iron deficiency (defined as ferritin greater than 200 ng/mL with TSAT (Transferrin saturation) less than 20%) is characterized by the presence of adequate iron stores as defined by conventional criteria, but with insufficient iron mobilization to adequately support.	Iron	11-15	transferrin	Homo sapiens	82-93
28033601-1	2016	Iron deficiency is one of the main causes of anemia in patients with chronic kidney disease, and iron supplements along the erythropoietin constitute the basis of its therapy.	Iron	97-101	erythropoietin	Homo sapiens	124-138
26491070-2	2015	Here we demonstrate that mutations in HSPA9, a mitochondrial HSP70 homolog located in the chromosome 5q deletion syndrome 5q33 critical deletion interval and involved in mitochondrial Fe-S biogenesis, result in CSA inherited as an autosomal recessive trait.	Iron	184-188	heat shock protein family A (Hsp70) member 9	Homo sapiens	38-43
26671928-4	2015	TET proteins (TET1, TET2, TET3) are iron(II) and alpha-ketoglutarate dependent dioxygenases, and their enzymatic activity involves hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine and 5-carboxylcytosine.	Iron	36-40	tet methylcytosine dioxygenase 3	Homo sapiens	26-30
26672975-6	2015	We also demonstrate the operation of this phenomenon during inflammation, as an arm of the innate immune response where lactoferrin denies iron to invading microorganisms by chelating it and then itself being sequestered into surrounding host cells by GAPDH.	Iron	139-143	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	252-257
26523985-5	2015	KEY FINDINGS: Chronic iron administration increased serum iron and transferrin saturation with significant deposition in the liver.	Iron	22-26	transferrin	Rattus norvegicus	67-78
26183475-5	2015	We review the role of iron 1) in the oxygen sensing process and erythropoietin (Epo) synthesis, 2) in gene expression control mediated by the hypoxia-inducible factor-2 (HIF-2), and 3) as an oxygen carrier in hemoglobin, myoglobin, and cytochromes.	Iron	22-26	erythropoietin	Homo sapiens	64-78
26183475-5	2015	We review the role of iron 1) in the oxygen sensing process and erythropoietin (Epo) synthesis, 2) in gene expression control mediated by the hypoxia-inducible factor-2 (HIF-2), and 3) as an oxygen carrier in hemoglobin, myoglobin, and cytochromes.	Iron	22-26	erythropoietin	Homo sapiens	80-83
26183475-6	2015	The blood hormone Epo that is abundantly expressed by the kidney under hypoxic conditions stimulates erythropoiesis in the bone marrow, a process requiring high iron levels.	Iron	161-165	erythropoietin	Homo sapiens	18-21
26183475-7	2015	To ensure that sufficient iron is provided, Epo-controlled erythroferrone that is expressed in erythroid precursor cells acts in the liver to reduce expression of the iron hormone hepcidin.	Iron	26-30	erythropoietin	Homo sapiens	44-47
26183475-7	2015	To ensure that sufficient iron is provided, Epo-controlled erythroferrone that is expressed in erythroid precursor cells acts in the liver to reduce expression of the iron hormone hepcidin.	Iron	167-171	erythropoietin	Homo sapiens	44-47
26523985-8	2015	Iron overload-induced vascular hyperactivity was reversed by incubation with tiron, catalase, apocynin, allopurinol and losartan.	Iron	0-4	catalase	Rattus norvegicus	84-92
26523985-9	2015	Moreover, malondialdehyde was elevated in the plasma, and O2( -) generation and NADPH oxidase subunit (p22phox) expression were increased in the aortas of iron-loaded rats.	Iron	155-159	cytochrome b-245 alpha chain	Rattus norvegicus	103-110
26616369-4	2015	Iron status was displayed by an increase in transferrin saturation (up to 332%) and serum and liver iron burden (up to 19.3 mumol L-1 and 13.2 mumol g-1 wet tissue, respectively) together with a drop in total and unsaturated iron binding capacities "TIBC, UIBC" as surrogate markers of transferrin activity.	Iron	0-4	transferrin	Rattus norvegicus	44-55
27307830-0	2009	Pantothenate kinase 2 deficiency: A neurodegeneration with brain iron accumulation.	Iron	65-69	pantothenate kinase 2	Homo sapiens	0-21
26616369-4	2015	Iron status was displayed by an increase in transferrin saturation (up to 332%) and serum and liver iron burden (up to 19.3 mumol L-1 and 13.2 mumol g-1 wet tissue, respectively) together with a drop in total and unsaturated iron binding capacities "TIBC, UIBC" as surrogate markers of transferrin activity.	Iron	0-4	transferrin	Rattus norvegicus	286-297
26385264-0	2015	The V736A TMPRSS6 polymorphism influences liver iron concentration in nontransfusion-dependent thalassemias.	Iron	48-52	transmembrane serine protease 6	Homo sapiens	10-17
26609730-1	2015	WDR45 mutations cause neurodegeneration with brain iron accumulation, usually presenting with early childhood developmental delay and followed by early adulthood extrapyramidal symptoms.	Iron	51-55	WD repeat domain 45	Homo sapiens	0-5
26407665-3	2015	Here we compare the influence of hydrogen peroxide and the ferrous iron (reagent for Fenton reaction) on the enzymatic activity of recombinant CD45, LAR, PTP1B phosphatases and cellular CD45 in Jurkat cells.	Iron	59-71	protein tyrosine phosphatase receptor type F	Homo sapiens	149-152
26407665-5	2015	We found that the higher concentrations of ferrous iron (II) increase the inactivation of CD45, LAR and PTP1B phosphatase caused by hydrogen peroxide, but the addition of the physiological concentration (500 nM) of ferrous iron (II) has even a slightly preventive effect on the phosphatase activity against hydrogen peroxide.	Iron	43-55	protein tyrosine phosphatase receptor type F	Homo sapiens	96-99
26840464-12	2015	The total iron dose ranged from 1,000 to 2,000 mg, with an average of 1,650 mg. Crohn"s disease activity measured using CDAI and C-reactive protein correlated with the intensity of anemia.	Iron	10-14	codanin 1	Homo sapiens	120-124
26840464-12	2015	The total iron dose ranged from 1,000 to 2,000 mg, with an average of 1,650 mg. Crohn"s disease activity measured using CDAI and C-reactive protein correlated with the intensity of anemia.	Iron	10-14	C-reactive protein	Homo sapiens	129-147
25964094-3	2015	Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload.	Iron	22-26	transferrin	Homo sapiens	4-15
26546695-0	2015	Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption.	Iron	89-93	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
27011992-2	2015	With the addition of ZVI, the biological autotrophic denitrification process could be reacted in the influent condition of pH was 7-8, at 35 C +-0.5 C, the concentration of ammonia was 50-100 mg   L-1 and the concentration of nitrate was 50-100 mg   L-1.	Iron	21-24	immunoglobulin kappa variable 1-16	Homo sapiens	197-200
26454080-0	2015	Targeting iron-mediated retinal degeneration by local delivery of transferrin.	Iron	10-14	transferrin	Rattus norvegicus	66-77
26454080-2	2015	Iron retinal homeostasis is highly regulated and transferrin (Tf), a potent iron chelator, is endogenously secreted by retinal cells.	Iron	76-80	transferrin	Rattus norvegicus	49-60
26454080-2	2015	Iron retinal homeostasis is highly regulated and transferrin (Tf), a potent iron chelator, is endogenously secreted by retinal cells.	Iron	76-80	transferrin	Rattus norvegicus	62-64
26454080-6	2015	We found an association between Tf treatment and the modulation of iron homeostasis resulting in a decrease of iron content and oxidative stress marker.	Iron	67-71	transferrin	Rattus norvegicus	32-34
26454080-6	2015	We found an association between Tf treatment and the modulation of iron homeostasis resulting in a decrease of iron content and oxidative stress marker.	Iron	111-115	transferrin	Rattus norvegicus	32-34
27011992-2	2015	With the addition of ZVI, the biological autotrophic denitrification process could be reacted in the influent condition of pH was 7-8, at 35 C +-0.5 C, the concentration of ammonia was 50-100 mg   L-1 and the concentration of nitrate was 50-100 mg   L-1.	Iron	21-24	immunoglobulin kappa variable 1-16	Homo sapiens	250-253
25964094-3	2015	Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload.	Iron	59-63	transferrin	Homo sapiens	4-15
25964094-3	2015	Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload.	Iron	59-63	transferrin	Homo sapiens	4-15
26370551-1	2015	Haptoglobin (Hp), a heme-Iron chelator, has different isoforms which are associated with variable tendency toward infections: Hp 1-1, Hp 2-1, and Hp 2-2.	Iron	25-29	haptoglobin	Homo sapiens	0-11
26468126-3	2015	Here we show that mutants in Drosophila mitoferrin (dmfrn), the gene encoding a mitochondrial carrier protein implicated in mitochondrial iron import, fail to grow and initiate metamorphosis under dietary iron depletion or when ferritin function is partially compromised.	Iron	138-142	mitoferrin	Drosophila melanogaster	40-50
26468126-3	2015	Here we show that mutants in Drosophila mitoferrin (dmfrn), the gene encoding a mitochondrial carrier protein implicated in mitochondrial iron import, fail to grow and initiate metamorphosis under dietary iron depletion or when ferritin function is partially compromised.	Iron	138-142	mitoferrin	Drosophila melanogaster	52-57
26468126-3	2015	Here we show that mutants in Drosophila mitoferrin (dmfrn), the gene encoding a mitochondrial carrier protein implicated in mitochondrial iron import, fail to grow and initiate metamorphosis under dietary iron depletion or when ferritin function is partially compromised.	Iron	205-209	mitoferrin	Drosophila melanogaster	40-50
26468126-3	2015	Here we show that mutants in Drosophila mitoferrin (dmfrn), the gene encoding a mitochondrial carrier protein implicated in mitochondrial iron import, fail to grow and initiate metamorphosis under dietary iron depletion or when ferritin function is partially compromised.	Iron	205-209	mitoferrin	Drosophila melanogaster	52-57
26468126-4	2015	In mutant dmfrn larvae reared under iron replete conditions, the expression of halloween genes is increased and 20-hydroxyecdysone (20E), the active form of ecdysone, is synthesized.	Iron	36-40	mitoferrin	Drosophila melanogaster	10-15
26468126-5	2015	In contrast, addition of an iron chelator to the diet of mutant dmfrn larvae disrupts 20E synthesis.	Iron	28-32	mitoferrin	Drosophila melanogaster	64-69
26468126-6	2015	Dietary addition of 20E has little effect on the growth defects, but enables approximately one-third of the iron-deprived dmfrn larvae to successfully turn into pupae and, in a smaller percentage, into adults.	Iron	108-112	mitoferrin	Drosophila melanogaster	122-127
26670435-14	2015	It is suggested that iron metabolism is substantially disturbed in non-diabetic obese and type 2 diabetic rats probably by the abnormal expression of hepcidin in chronic inflammatory status.	Iron	21-25	hepcidin antimicrobial peptide	Rattus norvegicus	150-158
26670435-15	2015	The increased hepcidin may restrain the iron release from the cells by affecting the expression of Fpn, which probably associates with the development of diabetic complication.	Iron	40-44	hepcidin antimicrobial peptide	Rattus norvegicus	14-22
26383538-4	2015	Excess levels of reactive oxygen species (ROS) and accumulated iron due to iron overload induced mitochondrial dysfunction, leading to a decrease in cellular adenosine triphosphate content and cytochrome c oxidase III expression, with an associated increase in gluconeogenesis.	Iron	63-67	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	193-217
26383538-4	2015	Excess levels of reactive oxygen species (ROS) and accumulated iron due to iron overload induced mitochondrial dysfunction, leading to a decrease in cellular adenosine triphosphate content and cytochrome c oxidase III expression, with an associated increase in gluconeogenesis.	Iron	75-79	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	193-217
26383538-5	2015	Disturbances in mitochondrial function caused excess iron deposition and unbalanced expression of iron metabolism-related proteins such as hepcidin, ferritin H and ferroportin during the activation of p38 mitogen-activated protein kinase (MAPK) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), which are responsible for increased phosphoenolpyruvate carboxykinase expression.	Iron	98-102	mitogen-activated protein kinase 14	Homo sapiens	201-237
26383538-6	2015	Desferoxamine and n-acetylcysteine ameliorated these deteriorations by inhibiting p38 MAPK and C/EBPalpha activity through iron chelation and ROS scavenging activity.	Iron	123-127	CCAAT enhancer binding protein alpha	Homo sapiens	95-105
26629341-3	2015	IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which has a key role in iron homeostasis.	Iron	30-34	iron responsive element binding protein 2	Homo sapiens	0-5
26629341-3	2015	IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which has a key role in iron homeostasis.	Iron	30-34	iron responsive element binding protein 2	Homo sapiens	57-61
26629341-4	2015	This review addresses pathways involved in iron metabolism, particularly focusing on the role of IREB2.	Iron	43-47	iron responsive element binding protein 2	Homo sapiens	97-102
26209813-6	2015	Further analysis demonstrated that the NO-dependent increase in iron deposition was mediated through increased transferrin receptor expression and a decrease in ferritin expression.	Iron	64-68	transferrin	Rattus norvegicus	111-122
26175145-2	2015	FPC donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration.	Iron	12-16	transferrin	Homo sapiens	29-40
26634903-7	2015	In addition, at day 28 when the exacerbation of uTP occurs, a significant correlation was observed between iron deposition in the kidney and urinary L-FABP.	Iron	107-111	fatty acid binding protein 1	Rattus norvegicus	149-155
26702071-9	2015	Moreover, renal mRNAs encoding the antioxidant proteins superoxide dismutase, catalase, and most of the glutathione synthetic system were suppressed, which would magnify the prooxidant effects of renal iron loads.	Iron	202-206	catalase	Rattus norvegicus	78-86
26550848-1	2015	A unique cooperative H2 activation reaction by heterobimetallic (NHC)M"-MCp(CO)2 complexes (NHC = N-heterocyclic carbene, M" = Cu or Ag, M = Fe or Ru) has been leveraged to develop a catalytic alkyne semi-hydrogenation transformation.	Iron	141-143	CD46 molecule	Homo sapiens	72-75
26605946-7	2015	The iron scores of DN-HCCs and overt HCCs were significantly lower than those of background livers [(0.091+-0.30) VS (2.18+-0.87), P = 0.000; (0.11+-0.41) VS (2.16+-0.97), P = 0.000; respectively].	Iron	4-8	holocytochrome c synthase	Homo sapiens	22-26
26700986-1	2015	OBJECTIVE: Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS).	Iron	72-76	insulin	Homo sapiens	23-30
26700986-6	2015	RESULTS: Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls.	Iron	40-44	transferrin	Homo sapiens	22-33
26605946-7	2015	The iron scores of DN-HCCs and overt HCCs were significantly lower than those of background livers [(0.091+-0.30) VS (2.18+-0.87), P = 0.000; (0.11+-0.41) VS (2.16+-0.97), P = 0.000; respectively].	Iron	4-8	holocytochrome c synthase	Homo sapiens	37-41
26635045-3	2015	In case of inflammation, the interpretation of usual biomarkers of iron deficiency (serum ferritin, transferrin saturation, serum iron) may be difficult.	Iron	67-71	transferrin	Homo sapiens	100-111
26618110-0	2015	Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis.	Iron	76-80	insulin	Homo sapiens	15-22
26618110-11	2015	The alanine aminotransferase was correlated with serum ferritin concentration (P = 0.02 to &lt; 0.000001) but not with insulin sensitivity, suggesting the role of the liver in iron-associated insulin resistance.	Iron	176-180	insulin	Homo sapiens	192-199
26471260-7	2015	Quantum tunneling is recovered as the switching mechanism at extremely low temperatures below the muK range for a six-Fe-atom system and exponentially lower for larger atomic systems.	Iron	118-120	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	98-101
26241638-2	2015	Non-Transferrin Bound Iron (NTBI) induces cardiac toxicity through the production of reactive oxygen species and lipid peroxidation.	Iron	22-26	transferrin	Homo sapiens	4-15
26740874-1	2016	BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN), sickle cell anemia, and thalassemia are autosomal recessive disorders that can cause iron deposition in tissues during childhood.	Iron	154-158	pantothenate kinase 2	Homo sapiens	12-60
26740874-1	2016	BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN), sickle cell anemia, and thalassemia are autosomal recessive disorders that can cause iron deposition in tissues during childhood.	Iron	154-158	pantothenate kinase 2	Homo sapiens	62-66
26740874-2	2016	PKAN is characterized by accumulation of iron in the basal ganglia causing progressive extrapyramidal manifestations.	Iron	41-45	pantothenate kinase 2	Homo sapiens	0-4
26547178-4	2015	A role for the application of INS in magnetic characterisation of iron based FTS catalysts is briefly considered.	Iron	66-70	AKT interacting protein	Homo sapiens	77-80
26172594-11	2015	Iron concentration was inversely associated with IFN-gamma and positively associated with viral titre and hysteresivity.	Iron	0-4	interferon gamma	Mus musculus	49-58
26299431-1	2015	Almost all known members of the cytochrome P450 (CYP) superfamily conserve a key cysteine residue that coordinates the heme iron.	Iron	124-128	ATZ20_RS10695	Sulfolobus acidocaldarius	32-47
26299431-1	2015	Almost all known members of the cytochrome P450 (CYP) superfamily conserve a key cysteine residue that coordinates the heme iron.	Iron	124-128	ATZ20_RS10695	Sulfolobus acidocaldarius	49-52
26556366-1	2015	Ovotransferrin or conalbumin belong to the transferrin protein family and is endowed with both iron-transfer and protective activities.	Iron	95-99	transferrin	Homo sapiens	3-14
26275495-8	2015	CONCLUSIONS: SIH iron chelators display both prooxidant (increasing the autoxidation rate of Fe(2+)) and antioxidant (activating Nrf2 signaling) effects.	Iron	17-21	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
26294793-10	2015	CONCLUSIONS: The observed associations of several markers of iron metabolism with hyperglycemia and insulin resistance suggest that iron stores as well as iron-related metabolic pathways contribute to the pathogenesis of IGM and T2DM.	Iron	61-65	insulin	Homo sapiens	100-107
26419736-9	2015	The key role of the NRF2 pathway in the antiapoptotic effect mediated by Fe and PM was demonstrated using siRNA technology.	Iron	73-75	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
26419736-10	2015	Our results suggest that the iron component participates in the antiapoptotic effect of PM by activating a NRF2-dependent antioxidant process.	Iron	29-33	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
26332507-7	2015	Overexpression of the iron exporter ferroportin-1 in Lcn2(-/-) macrophages represses IL-10 and restores TNF-alpha and IL-6 production to the levels found in wild-type macrophages, so that killing and clearance of intracellular Salmonella is promoted.	Iron	22-26	interleukin 10	Mus musculus	85-90
26294793-10	2015	CONCLUSIONS: The observed associations of several markers of iron metabolism with hyperglycemia and insulin resistance suggest that iron stores as well as iron-related metabolic pathways contribute to the pathogenesis of IGM and T2DM.	Iron	132-136	insulin	Homo sapiens	100-107
26294793-10	2015	CONCLUSIONS: The observed associations of several markers of iron metabolism with hyperglycemia and insulin resistance suggest that iron stores as well as iron-related metabolic pathways contribute to the pathogenesis of IGM and T2DM.	Iron	132-136	insulin	Homo sapiens	100-107
26310624-0	2015	Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.	Iron	79-83	serpin family A member 1	Homo sapiens	32-51
26310624-1	2015	Liver disease due to alpha-1-antitrypsin deficiency (A1ATD) is associated with hepatic iron overload in a subgroup of patients.	Iron	87-91	serpin family A member 1	Homo sapiens	21-40
26310624-3	2015	The aim of the present study was to define the genetics of this correlation and the effect of alpha-1-antitrypsin (A1AT) on the expression of the iron hormone hepcidin.	Iron	146-150	serpin family A member 1	Homo sapiens	94-113
26310624-3	2015	The aim of the present study was to define the genetics of this correlation and the effect of alpha-1-antitrypsin (A1AT) on the expression of the iron hormone hepcidin.	Iron	146-150	serpin family A member 1	Homo sapiens	115-119
26578919-16	2015	The number of iron-containing cells in CA3 correlated positively with the average RM score during acquisition across all animals.	Iron	14-18	carbonic anhydrase 3	Homo sapiens	39-42
26553631-0	2015	Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung.	Iron	37-39	interleukin 13	Mus musculus	67-71
26315622-6	2015	After multivariate adjustment, a positive association was found between transferrin and incident METS in men: odds ratio (OR) and 95% confidence interval for the fourth relative to the first quartile 1.55 (1.04-2.31), p for trend = 0.03, while no association was found for iron OR = 0.81 (0.53-1.24), p for trend = 0.33 and ferritin OR = 1.30 (0.88-1.92), p for trend = 0.018.	Iron	273-277	transferrin	Homo sapiens	72-83
26315622-7	2015	In women, a negative association was found between iron and incident METS: OR for the fourth relative to the first quartile 0.51 (0.33-0.80), p for trend&lt;0.03; the association between transferrin and incident METS was borderline significant: OR = 1.45 (0.97-2.17), p for trend = 0.07 and no association was found for ferritin: OR = 1.11 (0.76-1.63), p for trend = 0.58.	Iron	51-55	transferrin	Homo sapiens	187-198
26333047-8	2015	Under Fe-limited conditions, glutathione-deficient mutants, zir1, pad2 and cad2 accumulated lower levels of Fe than the wild type.	Iron	6-8	proteasome alpha subunit D2	Arabidopsis thaliana	66-70
26333047-8	2015	Under Fe-limited conditions, glutathione-deficient mutants, zir1, pad2 and cad2 accumulated lower levels of Fe than the wild type.	Iron	6-8	cinnamyl alcohol dehydrogenase homolog 2	Arabidopsis thaliana	75-79
26333047-8	2015	Under Fe-limited conditions, glutathione-deficient mutants, zir1, pad2 and cad2 accumulated lower levels of Fe than the wild type.	Iron	108-110	proteasome alpha subunit D2	Arabidopsis thaliana	66-70
26333047-8	2015	Under Fe-limited conditions, glutathione-deficient mutants, zir1, pad2 and cad2 accumulated lower levels of Fe than the wild type.	Iron	108-110	cinnamyl alcohol dehydrogenase homolog 2	Arabidopsis thaliana	75-79
26475181-7	2015	Dietary Pi regulated the messenger RNA expression of iron-regulated genes, including divalent metal transporter 1, duodenal cytochrome B, and hepcidin.	Iron	53-57	hepcidin antimicrobial peptide	Rattus norvegicus	142-150
26209973-8	2015	Moreover, Fe transport-related genes (NtPIC1, NtNRAMP1, and NtFER1) were upregulated in NtPIC1-OE plants, while Fe deficiency-related genes (NtFRO1, NtIRT1, and NtZIP1) that mediate Cd uptake were downregulated.	Iron	10-12	ferritin-1, chloroplastic	Nicotiana tabacum	60-66
26276665-2	2015	Erythroferrone (ERFE) is an erythroid regulator of hepcidin synthesis and iron homeostasis.	Iron	74-78	erythroferrone	Mus musculus	16-20
26529007-0	2015	Iron Absorption from Two Milk Formulas Fortified with Iron Sulfate Stabilized with Maltodextrin and Citric Acid.	Iron	0-4	Weaning weight-maternal milk	Bos taurus	25-29
26529007-1	2015	BACKGROUND: Fortification of milk formulas with iron is a strategy widely used, but the absorption of non-heme iron is low.	Iron	48-52	Weaning weight-maternal milk	Bos taurus	29-33
26529007-1	2015	BACKGROUND: Fortification of milk formulas with iron is a strategy widely used, but the absorption of non-heme iron is low.	Iron	111-115	Weaning weight-maternal milk	Bos taurus	29-33
26529007-2	2015	The purpose of this study was to measure the bioavailability of two iron fortified milk formulas designed to cover toddlers  nutritional needs.	Iron	68-72	Weaning weight-maternal milk	Bos taurus	83-87
26506412-1	2015	Mutations in PLA2G6 have been proposed to be the cause of neurodegeneration with brain iron accumulation type 2.	Iron	87-91	phospholipase A2, group VI	Mus musculus	13-19
26506412-2	2015	The present study aimed to clarify the mechanism underlying brain iron accumulation during the deficiency of calcium-independent phospholipase A2 beta (iPLA2beta), which is encoded by the PLA2G6 gene.	Iron	66-70	phospholipase A2, group VI	Mus musculus	152-161
26506412-2	2015	The present study aimed to clarify the mechanism underlying brain iron accumulation during the deficiency of calcium-independent phospholipase A2 beta (iPLA2beta), which is encoded by the PLA2G6 gene.	Iron	66-70	phospholipase A2, group VI	Mus musculus	188-194
26506412-6	2015	We have discovered for the first time that marked iron deposition was observed in the brains of iPLA2beta-KO mice since the early clinical stages.	Iron	50-54	phospholipase A2, group VI	Mus musculus	96-105
26506412-11	2015	These results suggest that the genetic ablation of iPLA2beta increased iron uptake in the brain through the activation of IRP2 and upregulation of DMT1, which may be associated with mitochondrial dysfunction.	Iron	71-75	phospholipase A2, group VI	Mus musculus	51-60
26276665-6	2015	The loss of ERFE in thalassemic mice led to full restoration of hepcidin mRNA expression at 3 and 6 weeks of age, and significant reduction in liver and spleen iron content at 6 and 12 weeks of age.	Iron	160-164	erythroferrone	Mus musculus	12-16
26342079-2	2015	In mammalian mitochondria, the initial step of the Fe-S cluster assembly process is assisted by the NFS1-ISD11 complex, which delivers sulfur to scaffold protein ISCU during Fe-S cluster synthesis.	Iron	51-55	LYR motif containing 4	Homo sapiens	105-110
26342079-2	2015	In mammalian mitochondria, the initial step of the Fe-S cluster assembly process is assisted by the NFS1-ISD11 complex, which delivers sulfur to scaffold protein ISCU during Fe-S cluster synthesis.	Iron	51-55	iron-sulfur cluster assembly enzyme	Homo sapiens	162-166
26342079-2	2015	In mammalian mitochondria, the initial step of the Fe-S cluster assembly process is assisted by the NFS1-ISD11 complex, which delivers sulfur to scaffold protein ISCU during Fe-S cluster synthesis.	Iron	174-178	iron-sulfur cluster assembly enzyme	Homo sapiens	162-166
26342079-4	2015	Our study maps the important ISD11 amino acid residues belonging to putative helix 1 (Phe-40), helix 3 (Leu-63, Arg-68, Gln-69, Ile-72, Tyr-76), and C-terminal segment (Leu-81, Glu-84) are critical for in vivo Fe-S cluster biogenesis.	Iron	210-214	LYR motif containing 4	Homo sapiens	29-34
26342079-6	2015	Due to altered interaction with ISD11 mutants, the levels of NFS1 and Isu1 were significantly depleted, which affects Fe-S cluster biosynthesis, leading to reduced electron transport chain complex (ETC) activity and mitochondrial respiration.	Iron	118-122	LYR motif containing 4	Homo sapiens	32-37
26342079-2	2015	In mammalian mitochondria, the initial step of the Fe-S cluster assembly process is assisted by the NFS1-ISD11 complex, which delivers sulfur to scaffold protein ISCU during Fe-S cluster synthesis.	Iron	174-178	LYR motif containing 4	Homo sapiens	105-110
26276665-8	2015	Thus, ERFE mediates hepcidin suppression and contributes to iron overload in a mouse model of beta-thalassemia.	Iron	60-64	erythroferrone	Mus musculus	6-10
26342079-8	2015	Our findings highlight that the ISD11 R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1 aggregation resulting in impairment of the Fe-S cluster biogenesis.	Iron	198-202	LYR motif containing 4	Homo sapiens	32-37
26342079-10	2015	Furthermore, the R68L ISD11 mutant displayed accumulation of mitochondrial iron and reactive oxygen species, leading to mitochondrial dysfunction, which correlates with the phenotype observed in COXPD19 patients.	Iron	75-79	LYR motif containing 4	Homo sapiens	22-27
26770400-6	2015	Results of comparation before and after the education program showed that with the enhance the EPO injection compliance and treat anemia with the proper dose of EPO, the PD patients have stable level of Hemoglobin, accompanying with the decreased dose of oral Iron and intravenous iron.	Iron	260-264	erythropoietin	Homo sapiens	95-98
26342079-10	2015	Furthermore, the R68L ISD11 mutant displayed accumulation of mitochondrial iron and reactive oxygen species, leading to mitochondrial dysfunction, which correlates with the phenotype observed in COXPD19 patients.	Iron	75-79	LYR motif containing 4	Homo sapiens	195-202
26494918-1	2015	In this issue of Blood, Kautz et al show that the ablation of the erythroid-derived factor erythroferrone (ERFE), which has been shown to be highly expressed in beta-thalassemic mice, restores hepcidin levels and corrects iron overload.	Iron	222-226	erythroferrone	Mus musculus	107-111
26492035-8	2015	Site-directed mutagenesis of ROS1 indicated that the conserved iron-sulfur motif is indispensable for ROS1 enzymatic activity.	Iron	63-67	demeter-like 1	Arabidopsis thaliana	29-33
26492035-8	2015	Site-directed mutagenesis of ROS1 indicated that the conserved iron-sulfur motif is indispensable for ROS1 enzymatic activity.	Iron	63-67	demeter-like 1	Arabidopsis thaliana	102-106
26492035-9	2015	Our results suggest that ROS1-mediated active DNA demethylation requires MET18-dependent transfer of the iron-sulfur cluster, highlighting an important role of the CIA pathway in epigenetic regulation.	Iron	105-109	demeter-like 1	Arabidopsis thaliana	25-29
26489858-5	2015	The colloidal stability and redox chemistry of the most and least toxic CNPs, CNP1 and CNP2, respectively, were modified by incubation with iron and phosphate buffers.	Iron	140-144	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	78-82
26489858-7	2015	Colloidal destabilization with Fe treatment only increased toxicity of CNP1.	Iron	31-33	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	71-75
26770400-6	2015	Results of comparation before and after the education program showed that with the enhance the EPO injection compliance and treat anemia with the proper dose of EPO, the PD patients have stable level of Hemoglobin, accompanying with the decreased dose of oral Iron and intravenous iron.	Iron	260-264	erythropoietin	Homo sapiens	161-164
26770400-6	2015	Results of comparation before and after the education program showed that with the enhance the EPO injection compliance and treat anemia with the proper dose of EPO, the PD patients have stable level of Hemoglobin, accompanying with the decreased dose of oral Iron and intravenous iron.	Iron	281-285	erythropoietin	Homo sapiens	95-98
26770400-6	2015	Results of comparation before and after the education program showed that with the enhance the EPO injection compliance and treat anemia with the proper dose of EPO, the PD patients have stable level of Hemoglobin, accompanying with the decreased dose of oral Iron and intravenous iron.	Iron	281-285	erythropoietin	Homo sapiens	161-164
26770400-8	2015	Treat anemia with proper dose of EPO individually could cure anemia effectively with the reducing of iron supplement improvement peritoneal dialysis patients" anemia related knowledge, and the good compliance of injection of EPO, serum iron and iron saturation could still keep stable, although declined intake of iron supplements.	Iron	101-105	erythropoietin	Homo sapiens	33-36
26770400-8	2015	Treat anemia with proper dose of EPO individually could cure anemia effectively with the reducing of iron supplement improvement peritoneal dialysis patients" anemia related knowledge, and the good compliance of injection of EPO, serum iron and iron saturation could still keep stable, although declined intake of iron supplements.	Iron	236-240	erythropoietin	Homo sapiens	33-36
26770400-8	2015	Treat anemia with proper dose of EPO individually could cure anemia effectively with the reducing of iron supplement improvement peritoneal dialysis patients" anemia related knowledge, and the good compliance of injection of EPO, serum iron and iron saturation could still keep stable, although declined intake of iron supplements.	Iron	236-240	erythropoietin	Homo sapiens	33-36
26770400-8	2015	Treat anemia with proper dose of EPO individually could cure anemia effectively with the reducing of iron supplement improvement peritoneal dialysis patients" anemia related knowledge, and the good compliance of injection of EPO, serum iron and iron saturation could still keep stable, although declined intake of iron supplements.	Iron	236-240	erythropoietin	Homo sapiens	33-36
26370442-4	2015	Electronic absorption and fluorescence titration studies of H3L with different metal cations show a distinctive recognition only towards Cu(2+) ions even in the presence of other commonly coexisting ions such as Li(+), Na(+), K(+), Mg(2+), Ca(2+), Fe(2+), Fe(3+), Mn(2+), Co(2+), Ni(2+), Zn(2+), Cd(2+) and Hg(2+).	Iron	248-250	H3 clustered histone 2	Homo sapiens	60-63
26329855-4	2015	It is noteworthy that the Y48pCMF mutation significantly destabilizes the Fe-Met bond in the ferric form of cytochrome c, thereby lowering the pKa value for the alkaline transition of the heme-protein.	Iron	74-76	cytochrome c, somatic	Homo sapiens	108-120
26528330-11	2015	Female hormones, and/or other factors they influence or are associated with (such as iron levels, temperature, testosterone) interact with SLC2A9 genotype in women to determine urate levels.	Iron	85-89	solute carrier family 2 member 9	Homo sapiens	139-145
26362814-7	2015	Our results support the model that the medial habenula responds to disease activity by upregulating transferrin receptor to facilitate the movement of iron into the brain from the third ventricle, raising the possibility that a similar mechanism accounts for iron accumulation in deep gray matter structures in patients with multiple sclerosis.	Iron	151-155	transferrin	Homo sapiens	100-111
26446565-5	2015	The DeltaPA4834 mutant was grown in AMS supplemented with 100 muM ferric iron, suggesting that the PA4834 gene product is involved in iron metabolism.	Iron	73-77	hypothetical protein	Pseudomonas aeruginosa PAO1	9-15
26359661-16	2015	In conclusion, our results indicate that the electron richness of the Fe2 core influences DeltaE t-H-mu-H, provided that (i) the R size of PR3 must be greater than that of Me and (ii) an electron donor must be bound to Fe apically.	Iron	70-72	familial progressive hyperpigmentation 1	Homo sapiens	101-105
26448442-0	2015	Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis.	Iron	101-105	cytokine induced apoptosis inhibitor 1	Homo sapiens	57-66
26448442-6	2015	Anamorsin is an electron transfer protein containing two iron-sulfur cluster-binding sites that is required for cytosolic Fe-S cluster assembly.	Iron	57-61	cytokine induced apoptosis inhibitor 1	Homo sapiens	0-9
26448442-6	2015	Anamorsin is an electron transfer protein containing two iron-sulfur cluster-binding sites that is required for cytosolic Fe-S cluster assembly.	Iron	122-126	cytokine induced apoptosis inhibitor 1	Homo sapiens	0-9
26517908-4	2015	In particular, ABC subfamily B member 7 (ABCB7) and its homologues in yeast and plants are required for iron-sulfur (Fe-S) cluster biosynthesis outside of the mitochondria, whereas ABCB10 is involved in haem biosynthesis.	Iron	117-121	ATP binding cassette subfamily B member 10	Homo sapiens	181-187
26183122-7	2015	In these patients, transfusion-associated hemolysis was accompanied by increases in circulating non-transferrin-bound iron and free hemoglobin and by an acute phase response, as assessed by an increase in median C-reactive protein levels of 21.2 mg/L (P &lt; 0.05).	Iron	118-122	transferrin	Homo sapiens	100-111
26664465-7	2015	CONCLUSION: Cerium is competitive element in the mechanism of iron absorption and can interfere and inhibit the growth of adenocarcinoma cancer cells; also, the use of Cerium and transferrin simultaneously may cause a greater inhibitory effect.	Iron	62-66	transferrin	Homo sapiens	179-190
26261881-0	2015	Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections.	Iron	21-25	transferrin	Homo sapiens	0-11
26261881-5	2015	Iron sequestration in mammals is predominantly mediated by the transferrin family of iron-binding proteins.	Iron	0-4	transferrin	Homo sapiens	63-74
26261881-5	2015	Iron sequestration in mammals is predominantly mediated by the transferrin family of iron-binding proteins.	Iron	85-89	transferrin	Homo sapiens	63-74
26261881-6	2015	In this review, we explore the possibility of administering supraphysiological levels of exogenous transferrin as an iron sequestering therapy for infections, which could overcome some of the problems associated with small molecule chelation.	Iron	117-121	transferrin	Homo sapiens	99-110
26099594-12	2015	TF severed as the carrier to delivery irons, and could directly stimulate cardiomyocytes hypertrophy.	Iron	38-43	transferrin	Homo sapiens	0-2
25346999-7	2015	Interestingly, levels of iron, the cofactor of catalase, were found to be significantly increased in liver and kidney.	Iron	25-29	catalase	Rattus norvegicus	47-55
26302480-2	2015	We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	285-289	cytokine induced apoptosis inhibitor 1	Homo sapiens	119-128
26364024-0	2015	Iron Requirements for Infants with Cow Milk Protein Allergy.	Iron	0-4	Weaning weight-maternal milk	Bos taurus	39-43
26302924-9	2015	In IL-10(-/-) mice, these changes were less marked or missing for non-haem iron.	Iron	75-79	interleukin 10	Mus musculus	3-8
26206271-0	2015	Iron primes 3T3-L1 adipocytes to a TLR4-mediated inflammatory response.	Iron	0-4	toll-like receptor 4	Mus musculus	35-39
26617777-13	2015	Expression levels of DMT1 and FPN1 were in parallel with ferrous iron deposition.	Iron	57-69	solute carrier family 40 member 1	Rattus norvegicus	30-34
26929573-7	2015	CONCLUSION: The present study demonstrated for the first time that the FE fraction from clove could confer UV-B protection probably through the Nrf2-ARE pathway, which included the down-regulation of Nrf2 and HO-1.	Iron	71-73	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
26929573-7	2015	CONCLUSION: The present study demonstrated for the first time that the FE fraction from clove could confer UV-B protection probably through the Nrf2-ARE pathway, which included the down-regulation of Nrf2 and HO-1.	Iron	71-73	NFE2 like bZIP transcription factor 2	Homo sapiens	200-204
26964313-3	2015	Thus, in the present study, the human amino-terminal fragment (hATF), as a targeting element to uPAR, is used to conjugate to the surface of superparamagnetic iron nanoparticle (SPIO).	Iron	159-163	glial cell derived neurotrophic factor	Homo sapiens	63-67
25960279-9	2015	This work revealed different mechanisms for the action of pharmacological chaperones and identifies a subtype of compounds that preserve TH activity by weak binding to the catalytic iron.	Iron	182-186	tyrosine hydroxylase	Homo sapiens	137-139
25944557-0	2015	Impact of Switching From Darbepoetin Alfa to Epoetin Beta Pegol on Iron Utilization and Blood Pressure in Peritoneal Dialysis Patients.	Iron	67-71	erythropoietin	Homo sapiens	45-52
26252621-2	2015	Oxidative stress derived from the iron accumulated in the amyloid plaques originating from amyloid beta (Abeta) peptides and neurofibrillary tangles derived from hyperphosphorylated tau proteins has been implicated in the pathogenesis of Alzheimer"s disease (AD).	Iron	34-38	amyloid beta precursor protein	Homo sapiens	91-103
26252621-2	2015	Oxidative stress derived from the iron accumulated in the amyloid plaques originating from amyloid beta (Abeta) peptides and neurofibrillary tangles derived from hyperphosphorylated tau proteins has been implicated in the pathogenesis of Alzheimer"s disease (AD).	Iron	34-38	amyloid beta precursor protein	Homo sapiens	105-110
26205815-2	2015	Steap family proteins are defined by a shared transmembrane domain that in Steap3 has been shown to function as a transmembrane electron shuttle, moving cytoplasmic electrons derived from NADPH across the lipid bilayer to the extracellular face where they are used to reduce Fe(3+) to Fe(2+) and potentially Cu(2+) to Cu(1+).	Iron	275-277	STEAP3 metalloreductase	Homo sapiens	75-81
26205815-2	2015	Steap family proteins are defined by a shared transmembrane domain that in Steap3 has been shown to function as a transmembrane electron shuttle, moving cytoplasmic electrons derived from NADPH across the lipid bilayer to the extracellular face where they are used to reduce Fe(3+) to Fe(2+) and potentially Cu(2+) to Cu(1+).	Iron	285-287	STEAP3 metalloreductase	Homo sapiens	75-81
25774043-6	2015	Lower levels of proinflammatory cytokine (IL-6, TNF-alpha, IFN-gamma, and IL-1beta) transcripts were detected in ileum of FeDex-treated piglets, which indicated that iron supplementation could attenuate the increase of inflammatory cytokines caused by iron deficiency.	Iron	166-170	interleukin 1 beta	Homo sapiens	74-82
26235415-6	2015	Thus, iron inaccessibility induces lower coefficient of transferrin saturation, which can lead to a non-regenerative normocytic or microcytic anaemia.	Iron	6-10	transferrin	Homo sapiens	56-67
26271913-1	2015	Iron ore was mined from the banded iron formations of Goa, India, and transported through the Mandovi and Zuari estuaries for six decades until the ban on mining from September 2012.	Iron	0-4	tripartite motif containing 47	Homo sapiens	54-57
26422103-10	2015	Increased level of NO-Fe-S clusters and 2-fold reduction of Fe-S cluster content were revealed in tumor tissue of mice after DCA and BC1 administration.	Iron	22-26	brain cytoplasmic RNA 1	Mus musculus	133-136
26422103-10	2015	Increased level of NO-Fe-S clusters and 2-fold reduction of Fe-S cluster content were revealed in tumor tissue of mice after DCA and BC1 administration.	Iron	60-64	brain cytoplasmic RNA 1	Mus musculus	133-136
26617777-18	2015	CONCLUSIONS: DMT1 and FPN1 are positively influenced by ferrous iron status in brain after ICH.	Iron	56-68	solute carrier family 40 member 1	Rattus norvegicus	22-26
26617777-19	2015	DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export.	Iron	24-28	solute carrier family 40 member 1	Rattus norvegicus	9-13
26617777-19	2015	DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export.	Iron	77-81	solute carrier family 40 member 1	Rattus norvegicus	9-13
25727755-1	2015	Transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1) are important proteins for cellular iron uptake, and both are regulated transcriptionally through the binding of hypoxia-inducible factor 1 (HIF-1) to hypoxia-responsive elements (HREs) under hypoxic conditions.	Iron	104-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	181-207
26133060-2	2015	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme that catalyzes the degradation of heme to yield biliverdin, CO and free iron.	Iron	122-126	heme oxygenase 1	Mus musculus	0-16
26133060-2	2015	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme that catalyzes the degradation of heme to yield biliverdin, CO and free iron.	Iron	122-126	heme oxygenase 1	Mus musculus	18-22
26104728-0	2015	Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetes.	Iron	22-26	transferrin	Homo sapiens	4-15
26208637-6	2015	By selectively loading the iron-chelating fluorochrome calcein in macropinosomes, we show that Dictyostelium Nramp1 mediates iron efflux from macropinosomes in vivo.	Iron	125-129	solute carrier family 11 member 1	Homo sapiens	109-115
26301810-7	2015	We found that iron negatively regulates leptin transcription via cAMP-responsive element binding protein activation (CREB activation) and identified 2 potential CREB-binding sites in the mouse leptin promoter region.	Iron	14-18	cAMP responsive element binding protein 1	Mus musculus	117-121
26301810-9	2015	ChIP analysis revealed that binding of phosphorylated CREB is enriched at these two sites in iron-treated 3T3-L1 adipocytes compared with untreated cells.	Iron	93-97	cAMP responsive element binding protein 1	Mus musculus	54-58
26301810-11	2015	These findings indicate that levels of dietary iron play an important role in regulation of appetite and metabolism through CREB-dependent modulation of leptin expression.	Iron	47-51	cAMP responsive element binding protein 1	Mus musculus	124-128
26208637-0	2015	Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux.	Iron	120-124	solute carrier family 11 member 1	Homo sapiens	14-20
26208637-4	2015	Nramp2 is located exclusively in the contractile vacuole membrane and controls, synergistically with Nramp1, iron homeostasis.	Iron	109-113	solute carrier family 11 member 1	Homo sapiens	101-107
26208637-5	2015	It has long been debated whether mammalian Nramp1 mediates iron import or export from phagosomes.	Iron	59-63	solute carrier family 11 member 1	Homo sapiens	43-49
26208637-6	2015	By selectively loading the iron-chelating fluorochrome calcein in macropinosomes, we show that Dictyostelium Nramp1 mediates iron efflux from macropinosomes in vivo.	Iron	27-31	solute carrier family 11 member 1	Homo sapiens	109-115
26104728-1	2015	AIMS: To investigate the association between circulating non-transferrin-bound iron [NTBI], and markers of oxidative stress, endothelial function and inflammation in subjects with type 2 diabetes and non-diabetic subjects with varying degrees of obesity.	Iron	79-83	transferrin	Homo sapiens	61-72
26329435-3	2015	Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from our understanding of RLS associations with a variety of medical, neurologic, and other conditions.	Iron	0-4	RLS1	Homo sapiens	133-136
26172578-9	2015	However, the magnitude of increase in iron concentration and the decrease in CRP concentration from admission to hospital discharge was higher in survivors than in nonsurvivors within the SIRS/septic group (22.8 vs. 2.51 mug/dL, respectively, P = 0.021 for iron; -67.1 vs. -4.1 mg/L, respectively, P = 0.002 for CRP), resulting in iron and CRP concentrations at hospital discharge for survivors similar to those in the focal inflammation group.	Iron	257-261	C-reactive protein	Canis lupus familiaris	77-80
26172578-9	2015	However, the magnitude of increase in iron concentration and the decrease in CRP concentration from admission to hospital discharge was higher in survivors than in nonsurvivors within the SIRS/septic group (22.8 vs. 2.51 mug/dL, respectively, P = 0.021 for iron; -67.1 vs. -4.1 mg/L, respectively, P = 0.002 for CRP), resulting in iron and CRP concentrations at hospital discharge for survivors similar to those in the focal inflammation group.	Iron	257-261	C-reactive protein	Canis lupus familiaris	77-80
26297648-0	2015	Quinol oxidase encoded by cyoABCD in Rhizobium etli CFN42 is regulated by ActSR and is crucial for growth at low pH or low iron conditions.	Iron	123-127	DoxX family protein	Rhizobium etli CFN 42	0-14
26329435-3	2015	Iron-dopamine connection, hypoxia pathway activation, and dopamine-opioid interaction are important pathophysiological mechanisms in RLS; this knowledge is derived from our understanding of RLS associations with a variety of medical, neurologic, and other conditions.	Iron	0-4	RLS1	Homo sapiens	190-193
26399527-1	2015	Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family.	Iron	18-22	transferrin	Homo sapiens	104-115
26228081-0	2015	Haptoglobin phenotype modifies serum iron levels and the effect of smoking on Parkinson disease risk.	Iron	37-41	haptoglobin	Homo sapiens	0-11
26228081-7	2015	Stratified analysis by haptoglobin phenotype was performed to determine effect of haptoglobin phenotype on serum iron parameter differences between PD cases and controls and to investigate its role in the protective effect of smoking on PD risk.	Iron	113-117	haptoglobin	Homo sapiens	82-93
26228081-11	2015	CONCLUSIONS: Our results report for the first time that the haptoglobin phenotype may be a contributor of iron levels abnormalities in PD patients.	Iron	106-110	haptoglobin	Homo sapiens	60-71
26088136-2	2015	Here we report that Prx1 proteins from Tetraodon nigroviridis and humans also possess a previously unknown catalase-like activity that is independent of Cys residues and reductants but dependent on iron.	Iron	198-202	catalase	Homo sapiens	107-115
26268514-5	2015	Haptoglobin (Hp) protein is the main line of defense against the oxidative effects of Hemoglobin/Iron.	Iron	97-101	haptoglobin	Homo sapiens	0-11
26196377-2	2015	In this work, we demonstrate that the NTE operation-temperature window of LaFe(13-x)Si(x) can be significantly broadened by adjusting Fe-Fe magnetic exchange coupling as x ranges from 2.8 to 3.1.	Iron	76-78	patatin like phospholipase domain containing 6	Homo sapiens	38-41
26196377-2	2015	In this work, we demonstrate that the NTE operation-temperature window of LaFe(13-x)Si(x) can be significantly broadened by adjusting Fe-Fe magnetic exchange coupling as x ranges from 2.8 to 3.1.	Iron	134-136	patatin like phospholipase domain containing 6	Homo sapiens	38-41
26196377-5	2015	The reduction of the overall Fe-Fe magnetic exchange interactions contributes to the broadness of NTE operation-temperature window for LaFe(13-x)Si(x).	Iron	29-31	patatin like phospholipase domain containing 6	Homo sapiens	98-101
26196377-5	2015	The reduction of the overall Fe-Fe magnetic exchange interactions contributes to the broadness of NTE operation-temperature window for LaFe(13-x)Si(x).	Iron	32-34	patatin like phospholipase domain containing 6	Homo sapiens	98-101
26270434-31	2015	It remains unclear which treatment modality is most effective in alleviating symptoms of postpartum anaemia.Intravenous iron was superior regarding gastrointestinal harms, however anaphylaxis and cardiac events occurred and more data are needed to establish whether this was caused by intravenous iron.The clinical significance of some temporarily improved fatigue scores in women treated with blood transfusion is uncertain and this modest effect should be balanced against known risks, e.g. maternal mortality (not reported) and maternal immunological sensitisation, which can potentially harm future pregnancies.When comparing oral iron to placebo it remains unknown whether efficacy (relief of anaemia symptoms) outweighs the documented gastrointestinal harms.We could not draw conclusions regarding erythropoietin treatment due to lack of evidence.Further research should evaluate treatment effect through clinical outcomes, i.e. presence and severity of anaemia symptoms balanced against harms, i.e. survival and severe morbidity.	Iron	120-124	erythropoietin	Homo sapiens	804-818
26248231-0	2015	Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells.	Iron	60-64	RAB35, member RAS oncogene family	Mus musculus	50-55
26125440-7	2015	Several key studies have revealed that iron chelation can target the AKT, ERK, JNK, p38, STAT3, TGF-beta, Wnt and autophagic pathways to subsequently inhibit cellular proliferation, the epithelial-mesenchymal transition (EMT) and metastasis.	Iron	39-43	AKT serine/threonine kinase 1	Homo sapiens	69-72
26125440-7	2015	Several key studies have revealed that iron chelation can target the AKT, ERK, JNK, p38, STAT3, TGF-beta, Wnt and autophagic pathways to subsequently inhibit cellular proliferation, the epithelial-mesenchymal transition (EMT) and metastasis.	Iron	39-43	mitogen-activated protein kinase 1	Homo sapiens	74-77
26125440-7	2015	Several key studies have revealed that iron chelation can target the AKT, ERK, JNK, p38, STAT3, TGF-beta, Wnt and autophagic pathways to subsequently inhibit cellular proliferation, the epithelial-mesenchymal transition (EMT) and metastasis.	Iron	39-43	mitogen-activated protein kinase 14	Homo sapiens	84-87
26125440-7	2015	Several key studies have revealed that iron chelation can target the AKT, ERK, JNK, p38, STAT3, TGF-beta, Wnt and autophagic pathways to subsequently inhibit cellular proliferation, the epithelial-mesenchymal transition (EMT) and metastasis.	Iron	39-43	signal transducer and activator of transcription 3	Homo sapiens	89-94
26125440-7	2015	Several key studies have revealed that iron chelation can target the AKT, ERK, JNK, p38, STAT3, TGF-beta, Wnt and autophagic pathways to subsequently inhibit cellular proliferation, the epithelial-mesenchymal transition (EMT) and metastasis.	Iron	39-43	transforming growth factor beta 1	Homo sapiens	96-104
26248231-6	2015	Rab35 plays a role in endosomal recycling of transferrin receptor (TfR), the key protein responsible for transferrin-mediated cellular iron uptake.	Iron	135-139	RAB35, member RAS oncogene family	Mus musculus	0-5
26248231-7	2015	UPEC enhance the expression of both Rab35 and TfR and recruit these proteins to the UCV, thereby supplying UPEC with the essential nutrient iron.	Iron	140-144	RAB35, member RAS oncogene family	Mus musculus	36-41
26248231-8	2015	Accordingly, Rab35 or TfR depleted cells showed significantly lower intracellular iron levels and reduced ability to support UPEC survival.	Iron	82-86	RAB35, member RAS oncogene family	Mus musculus	13-18
26248231-11	2015	We propose a model in which UPEC subverts two different vesicular trafficking pathways (endosomal recycling and degradative lysosomal fusion) by modulating Rab35, thereby simultaneously enhancing iron acquisition and avoiding lysosomal degradation of the UCV within bladder epithelial cells.	Iron	196-200	RAB35, member RAS oncogene family	Mus musculus	156-161
25860295-6	2015	Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX &lt; iron-free PPIX &lt; hemin &lt; Zn-PPIX.	Iron	116-120	fibrinogen beta chain	Homo sapiens	7-17
25860295-6	2015	Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX &lt; iron-free PPIX &lt; hemin &lt; Zn-PPIX.	Iron	157-161	fibrinogen beta chain	Homo sapiens	7-17
26032732-0	2015	Interaction of frataxin, an iron binding protein, with IscU of Fe-S clusters biogenesis pathway and its upregulation in AmpB resistant Leishmania donovani.	Iron	28-32	iron-sulfur cluster assembly enzyme	Homo sapiens	55-59
25912790-5	2015	Here we report that the cytotoxicity induced by iron exposure was two-fold reduced in CHO cells stably expressing the ATP13A2 recombinant protein (ATP13A2).	Iron	48-52	polyamine-transporting ATPase 13A2	Cricetulus griseus	118-125
25912790-5	2015	Here we report that the cytotoxicity induced by iron exposure was two-fold reduced in CHO cells stably expressing the ATP13A2 recombinant protein (ATP13A2).	Iron	48-52	polyamine-transporting ATPase 13A2	Cricetulus griseus	147-154
26032732-0	2015	Interaction of frataxin, an iron binding protein, with IscU of Fe-S clusters biogenesis pathway and its upregulation in AmpB resistant Leishmania donovani.	Iron	63-67	iron-sulfur cluster assembly enzyme	Homo sapiens	55-59
25988595-8	2015	Increased expression of DcytB and DMT1 genes in the duodenum resulting in increased iron availability was defined as the mechanism for these effects.	Iron	84-88	solute carrier family 11 member 2	Rattus norvegicus	34-38
25096756-0	2015	Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice.	Iron	49-53	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-14
25096756-1	2015	PURPOSE: Angiotensin II (ANG II) has been shown to affect iron metabolism through alteration of iron transporters, leading to increased cellular and tissue iron contents.	Iron	58-62	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	9-23
25096756-1	2015	PURPOSE: Angiotensin II (ANG II) has been shown to affect iron metabolism through alteration of iron transporters, leading to increased cellular and tissue iron contents.	Iron	58-62	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	25-31
25096756-1	2015	PURPOSE: Angiotensin II (ANG II) has been shown to affect iron metabolism through alteration of iron transporters, leading to increased cellular and tissue iron contents.	Iron	96-100	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	9-23
25096756-1	2015	PURPOSE: Angiotensin II (ANG II) has been shown to affect iron metabolism through alteration of iron transporters, leading to increased cellular and tissue iron contents.	Iron	96-100	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	25-31
26096995-2	2015	WDR45 is an X-linked gene associated with a dominant form of Neurodegeneration with Brain Iron Accumulation (NBIA), manifested by progressive disabilities, dystonia, cognitive decline, spastic paraplegia, neuropsychiatric abnormalities and iron deposition in the basal ganglia on brain imaging.	Iron	90-94	WD repeat domain 45	Homo sapiens	0-5
25096756-9	2015	In terms of tissue iron content, macrophage iron content and renal iron content were increased by ANG II treatment, and these increases were associated with reduced expression of transferrin receptor 1 and FPN and increased expression of ferritin.	Iron	19-23	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	98-104
26096995-2	2015	WDR45 is an X-linked gene associated with a dominant form of Neurodegeneration with Brain Iron Accumulation (NBIA), manifested by progressive disabilities, dystonia, cognitive decline, spastic paraplegia, neuropsychiatric abnormalities and iron deposition in the basal ganglia on brain imaging.	Iron	240-244	WD repeat domain 45	Homo sapiens	0-5
25096756-9	2015	In terms of tissue iron content, macrophage iron content and renal iron content were increased by ANG II treatment, and these increases were associated with reduced expression of transferrin receptor 1 and FPN and increased expression of ferritin.	Iron	44-48	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	98-104
25096756-9	2015	In terms of tissue iron content, macrophage iron content and renal iron content were increased by ANG II treatment, and these increases were associated with reduced expression of transferrin receptor 1 and FPN and increased expression of ferritin.	Iron	44-48	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	98-104
25096756-11	2015	CONCLUSIONS: Angiotensin II (ANG II) altered the expression of duodenal iron transporters and reduced hepcidin levels, contributing to the alteration of body iron distribution.	Iron	72-76	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	13-27
25096756-11	2015	CONCLUSIONS: Angiotensin II (ANG II) altered the expression of duodenal iron transporters and reduced hepcidin levels, contributing to the alteration of body iron distribution.	Iron	72-76	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	29-35
25115800-0	2015	Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats.	Iron	26-30	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
25890482-4	2015	In this study, total reflection X-ray fluorescence (TXRF) was used to detect iron and zinc in PP1 that was purified from rabbit skeletal muscle.	Iron	77-81	inorganic pyrophosphatase 1	Homo sapiens	94-97
25890482-6	2015	We also found that the iron level associated with native PP1 is decreased by incubation with inhibitor-2, consistent with a function of inhibitor-2 as a PP1 chaperone.	Iron	23-27	inorganic pyrophosphatase 1	Homo sapiens	57-60
25890482-6	2015	We also found that the iron level associated with native PP1 is decreased by incubation with inhibitor-2, consistent with a function of inhibitor-2 as a PP1 chaperone.	Iron	23-27	inorganic pyrophosphatase 1	Homo sapiens	153-156
25986992-2	2015	Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly.	Iron	76-80	fibrinogen beta chain	Homo sapiens	93-103
25986992-2	2015	Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly.	Iron	76-80	coagulation factor II, thrombin	Homo sapiens	123-131
25115800-4	2015	We demonstrated that hepcidin significantly reduced brain iron in iron-overloaded rats and suppressed transport of transferrin-bound iron (Tf-Fe) from the periphery into the brain.	Iron	58-62	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
25115800-4	2015	We demonstrated that hepcidin significantly reduced brain iron in iron-overloaded rats and suppressed transport of transferrin-bound iron (Tf-Fe) from the periphery into the brain.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
25115800-4	2015	We demonstrated that hepcidin significantly reduced brain iron in iron-overloaded rats and suppressed transport of transferrin-bound iron (Tf-Fe) from the periphery into the brain.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
25115800-4	2015	We demonstrated that hepcidin significantly reduced brain iron in iron-overloaded rats and suppressed transport of transferrin-bound iron (Tf-Fe) from the periphery into the brain.	Iron	142-144	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
25115800-4	2015	We demonstrated that hepcidin significantly reduced brain iron in iron-overloaded rats and suppressed transport of transferrin-bound iron (Tf-Fe) from the periphery into the brain.	Iron	142-144	transferrin	Rattus norvegicus	115-126
25115800-5	2015	Also, the peptide significantly inhibited expression of TfR1, DMT1, and Fpn1 as well as reduced Tf-Fe and non-transferrin-bound iron uptake and iron release in cultured microvascular endothelial cells and neurons, while downregulation of hepcidin with hepcidin siRNA retrovirus generated opposite results.	Iron	128-132	transferrin	Rattus norvegicus	110-121
25115800-6	2015	We concluded that, under iron-overload, hepcidin functions to reduce iron in the brain by downregulating iron transport proteins.	Iron	25-29	hepcidin antimicrobial peptide	Rattus norvegicus	40-48
25115800-6	2015	We concluded that, under iron-overload, hepcidin functions to reduce iron in the brain by downregulating iron transport proteins.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	40-48
25841783-0	2015	Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich"s ataxia.	Iron	21-25	mitoferrin	Drosophila melanogaster	0-10
25841783-7	2015	In the fly model exhibiting only partial frataxin loss, we demonstrated that the inability to activate ferritin translation and the enhancement of mitochondrial iron uptake via mitoferrin upregulation were likely the key molecular events behind the iron-induced phenotype.	Iron	249-253	mitoferrin	Drosophila melanogaster	177-187
25841783-11	2015	Taken together, this study demonstrates the crucial role of mitoferrin dysfunction in the etiology of Friedreich"s ataxia and provides evidence that impairment of mitochondrial iron transport could be an effective treatment of the disease.	Iron	177-181	mitoferrin	Drosophila melanogaster	60-70
25115800-6	2015	We concluded that, under iron-overload, hepcidin functions to reduce iron in the brain by downregulating iron transport proteins.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	40-48
25115800-0	2015	Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats.	Iron	62-66	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
25115800-7	2015	Upregulation of brain hepcidin by ad-hepcidin emerges as a new pharmacological treatment and prevention for iron-associated neurodegenerative disorders.	Iron	108-112	hepcidin antimicrobial peptide	Rattus norvegicus	22-30
25115800-7	2015	Upregulation of brain hepcidin by ad-hepcidin emerges as a new pharmacological treatment and prevention for iron-associated neurodegenerative disorders.	Iron	108-112	hepcidin antimicrobial peptide	Rattus norvegicus	37-45
25115800-2	2015	Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a role to reduce iron in the brain and hence has the potential to prevent or delay brain iron accumulation in iron-associated neurodegenerative disorders.	Iron	139-143	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
25115800-2	2015	Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a role to reduce iron in the brain and hence has the potential to prevent or delay brain iron accumulation in iron-associated neurodegenerative disorders.	Iron	211-215	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
25115800-2	2015	Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a role to reduce iron in the brain and hence has the potential to prevent or delay brain iron accumulation in iron-associated neurodegenerative disorders.	Iron	211-215	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
26002422-0	2015	Iron accumulation promotes TACE-mediated TNF-alpha secretion and neurodegeneration in a mouse model of ALS.	Iron	0-4	a disintegrin and metallopeptidase domain 17	Mus musculus	27-31
26002422-0	2015	Iron accumulation promotes TACE-mediated TNF-alpha secretion and neurodegeneration in a mouse model of ALS.	Iron	0-4	tumor necrosis factor	Mus musculus	41-50
26002422-3	2015	Here, we show that iron was accumulated in ventral motor neurons from SOD1(G93A)-transgenic mice even at 4 weeks of age, subsequently inducing oxidative stress.	Iron	19-23	superoxide dismutase 1, soluble	Mus musculus	70-74
26002422-4	2015	Iron chelation with deferoxamine mesylate delayed disease onset and extended lifespan of SOD1(G93A) mice.	Iron	0-4	superoxide dismutase 1, soluble	Mus musculus	89-93
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	32-36	superoxide dismutase 1, soluble	Mus musculus	13-17
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	32-36	a disintegrin and metallopeptidase domain 17	Mus musculus	101-128
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	32-36	a disintegrin and metallopeptidase domain 17	Mus musculus	130-134
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	32-36	tumor necrosis factor	Mus musculus	101-110
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	196-200	superoxide dismutase 1, soluble	Mus musculus	13-17
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	196-200	a disintegrin and metallopeptidase domain 17	Mus musculus	101-128
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	196-200	a disintegrin and metallopeptidase domain 17	Mus musculus	130-134
26002422-5	2015	Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress.	Iron	196-200	tumor necrosis factor	Mus musculus	101-110
26063801-3	2015	We have previously shown that Yap1 represses the expression of FET4, a gene encoding a low affinity iron transporter able to transport metals other than iron.	Iron	100-104	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	30-34
26002909-0	2015	GENERAL CONTROL NONREPRESSED PROTEIN5-Mediated Histone Acetylation of FERRIC REDUCTASE DEFECTIVE3 Contributes to Iron Homeostasis in Arabidopsis.	Iron	113-117	MATE efflux family protein	Arabidopsis thaliana	70-97
26002909-6	2015	Consistent with the function of FRD3 as a citrate efflux protein, the iron retention defect in gcn5 was rescued and fertility was partly restored by overexpressing FRD3.	Iron	70-74	MATE efflux family protein	Arabidopsis thaliana	32-36
26002909-6	2015	Consistent with the function of FRD3 as a citrate efflux protein, the iron retention defect in gcn5 was rescued and fertility was partly restored by overexpressing FRD3.	Iron	70-74	MATE efflux family protein	Arabidopsis thaliana	164-168
26002909-8	2015	Collectively, these data suggest that GCN5 plays a critical role in FRD3-mediated iron homeostasis.	Iron	82-86	MATE efflux family protein	Arabidopsis thaliana	68-72
26222542-3	2015	We demonstrated previously that the combination of the iron chelator 2,2"-bipyridine-5,5"-decarboxylic acid (BPY-DCA) and 8-Br-cyclic AMP (cAMP) inhibits scar formation and collagen deposition, leading to enhanced axon regeneration and partial functional recovery after spinal cord injury.	Iron	55-59	cathelicidin antimicrobial peptide	Rattus norvegicus	139-143
26063801-3	2015	We have previously shown that Yap1 represses the expression of FET4, a gene encoding a low affinity iron transporter able to transport metals other than iron.	Iron	100-104	Fet4p	Saccharomyces cerevisiae S288C	63-67
26198524-1	2015	Practice nurse Helen Coupland (nee Irons) was born in the Rhondda Valley in South Wales, and shared a happy childhood there with her younger brother, Ted.	Iron	35-40	NALCN channel auxiliary factor 2	Homo sapiens	150-153
26208277-2	2015	The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin complexes, respectively.	Iron	97-101	transferrin	Homo sapiens	109-120
26208277-8	2015	These results suggest that transferrin is the major source of iron for N. meningitidis during replication in healthy human blood.	Iron	62-66	transferrin	Homo sapiens	27-38
26160631-1	2015	BACKGROUND: Heme oxygenase-1 (HO-1) is an inducible stress-responsive enzyme converting heme to bilirubin, carbon monoxide, and free iron, which exerts anti-inflammatory and antiapoptotic effects.	Iron	133-137	heme oxygenase 1	Mus musculus	12-28
26144971-7	2015	We also identify non-overlapping hif-1 upstream (HIF-1-prolyl-hydroxylase) and downstream (globins) regulatory genes mediating lifespan extension upon frataxin and iron depletion.	Iron	164-168	Hypoxia-inducible factor 1	Caenorhabditis elegans	33-38
26144971-7	2015	We also identify non-overlapping hif-1 upstream (HIF-1-prolyl-hydroxylase) and downstream (globins) regulatory genes mediating lifespan extension upon frataxin and iron depletion.	Iron	164-168	Hypoxia-inducible factor 1	Caenorhabditis elegans	49-54
26160631-1	2015	BACKGROUND: Heme oxygenase-1 (HO-1) is an inducible stress-responsive enzyme converting heme to bilirubin, carbon monoxide, and free iron, which exerts anti-inflammatory and antiapoptotic effects.	Iron	133-137	heme oxygenase 1	Mus musculus	30-34
26236187-5	2015	Among the interstitial factors that regulate iron efflux into the brain is the Amyloid precursor protein (APP).	Iron	45-49	amyloid beta precursor protein	Homo sapiens	79-104
26185605-5	2015	Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10.	Iron	134-138	signal transducer and activator of transcription 3	Homo sapiens	76-81
26038984-4	2015	Herein we report a high-resolution crystal structure of a Lys73-ligated cyt c conformation that reveals intricate change in the heme environment upon this switch in the heme iron ligation.	Iron	136-140	cytochrome c, somatic	Homo sapiens	72-77
26185605-5	2015	Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10.	Iron	134-138	interleukin 6	Homo sapiens	235-239
26185605-5	2015	Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10.	Iron	134-138	tumor necrosis factor	Homo sapiens	241-268
26150144-10	2015	In the COPD cohort, CRP was higher in patients with iron deficiency (median 10.5 vs 4.0 mg/L, p&lt;0.001), who were also more hypoxaemic than their iron-replete counterparts (median resting SpO2 92% vs 95%, p&lt;0.001), but haemoglobin concentration did not differ.	Iron	52-56	C-reactive protein	Homo sapiens	20-23
26184159-4	2015	The overexpression of TfR1 was well tolerated by the cells but Fth1 was found to affect the cell"s iron homeostasis, leading to phenotypic changes in the absence of iron supplementation and an upregulation in transcript and protein levels of the cell"s endogenous transferrin receptor.	Iron	99-103	ferritin heavy chain 1	Gallus gallus	63-67
26184159-4	2015	The overexpression of TfR1 was well tolerated by the cells but Fth1 was found to affect the cell"s iron homeostasis, leading to phenotypic changes in the absence of iron supplementation and an upregulation in transcript and protein levels of the cell"s endogenous transferrin receptor.	Iron	165-169	ferritin heavy chain 1	Gallus gallus	63-67
26275690-6	2015	CRP was used to assess the correlation between the aforementioned markers of iron and inflammation.	Iron	77-81	C-reactive protein	Homo sapiens	0-3
25740381-10	2015	Since hepatic iron loading correlated with insulin resistance development, the insulin resistance among patients with BTM may partially be explained with decreased hepatic insulin clearance from heavily iron-loaded liver.	Iron	14-18	insulin	Homo sapiens	43-50
25819318-0	2015	DNA interaction, SOD, peroxidase and nuclease activity studies of iron complex having ligand with carboxamido nitrogen donors.	Iron	66-70	superoxide dismutase 1	Homo sapiens	17-20
25896304-0	2015	Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation.	Iron	69-73	hepcidin	Macaca fascicularis	108-116
25896304-1	2015	High levels of hepcidin, the main regulator of systemic iron metabolism, lead to various diseases.	Iron	56-60	hepcidin antimicrobial peptide	Rattus norvegicus	15-23
25896304-10	2015	When hepcidin levels were downregulated, iron deposition in the liver was visible histologically 1 week post application.	Iron	41-45	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
25740381-10	2015	Since hepatic iron loading correlated with insulin resistance development, the insulin resistance among patients with BTM may partially be explained with decreased hepatic insulin clearance from heavily iron-loaded liver.	Iron	203-207	insulin	Homo sapiens	79-86
26327704-6	2015	Generalized estimating equations developed from 313 observations obtained from these 148 patients suggested that average transferrin saturation percentage and iron concentration were both significantly higher in the group that received iron once weekly than in the group that received iron by the conventional accelerated regimen (p = 0.014 and 0.008, respectively).	Iron	236-240	transferrin	Homo sapiens	121-132
26276291-8	2015	CONCLUSIONS: Tf and TfR were important transporters in brain tissue excessive load iron transport after ICH, and detecting the expression levels of the two indicators can provide a reference for prognosis treatment in ICH.	Iron	83-87	transferrin	Rattus norvegicus	13-15
26327704-6	2015	Generalized estimating equations developed from 313 observations obtained from these 148 patients suggested that average transferrin saturation percentage and iron concentration were both significantly higher in the group that received iron once weekly than in the group that received iron by the conventional accelerated regimen (p = 0.014 and 0.008, respectively).	Iron	236-240	transferrin	Homo sapiens	121-132
25981872-2	2015	HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells.	Iron	36-40	transferrin	Homo sapiens	18-29
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Iron	65-69	solute carrier family 40 member 1	Rattus norvegicus	136-139
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Iron	168-172	solute carrier family 40 member 1	Rattus norvegicus	122-134
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Iron	168-172	solute carrier family 40 member 1	Rattus norvegicus	136-139
25656940-9	2015	These results show that FP1 and CP colocalize in the rat brain, indicating the coordinated actions of the two proteins in the cellular iron export, and suggest that decreased expression of CP in the SN is involved in the nigral iron accumulation of 6-OHDA-lesioned rats.	Iron	135-139	solute carrier family 40 member 1	Rattus norvegicus	24-27
25656940-9	2015	These results show that FP1 and CP colocalize in the rat brain, indicating the coordinated actions of the two proteins in the cellular iron export, and suggest that decreased expression of CP in the SN is involved in the nigral iron accumulation of 6-OHDA-lesioned rats.	Iron	228-232	solute carrier family 40 member 1	Rattus norvegicus	24-27
25981872-2	2015	HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells.	Iron	79-83	transferrin	Homo sapiens	18-29
25862412-6	2015	Expression of exogenous PrP(C) in HepG2 cells increased uptake and storage of ferric iron (Fe(3+)), not ferrous iron (Fe(2+)), from the medium, supporting the function of PrP(C) as a plasma membrane FR.	Iron	85-89	prion protein	Homo sapiens	24-30
26099175-0	2015	The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins.	Iron	90-94	nuclear receptor coactivator 5	Homo sapiens	33-36
26085217-4	2015	In addition, through its ability to also add K48-linked polyubiquitin chains to specific substrates, HOIL-1 has been linked with antiviral signaling, iron and xenobiotic metabolism, cell death, and cancer.	Iron	150-154	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	101-107
25693854-13	2015	Similarly, increased renal gene expression of CD68, tumor necrosis factor-alpha and monocyte chemoattractant protein-1 was suppressed in CKD rats with iron chelation.	Iron	151-155	tumor necrosis factor	Rattus norvegicus	52-79
25386711-5	2015	RESULTS: Serum ferritin, serum iron, and transferrin saturation were significantly improved in the iron group after intervention and compared with those in placebo (P &lt; 0.05).	Iron	99-103	transferrin	Homo sapiens	41-52
26199472-13	2015	Iron status evaluation done in 44 patients after a follow up period of 15.1 +- 11.5 weeks showed increases in Hb of 1.6 +- 2.2 g/dl (P = 0.001), transferrin saturation of 9.1 +- 16.9% (P = 0.001), and ferritin of 406 +- 449 ng/ml (P = 0.001).	Iron	0-4	transferrin	Homo sapiens	145-156
26393116-1	2015	BACKGROUND: Myeloperoxidase (MPO) is a myelocyte derived iron containing enzyme particularly involved in host defense by destroying foreign micro organisms invading the body.	Iron	57-61	myeloperoxidase	Homo sapiens	12-27
26393116-1	2015	BACKGROUND: Myeloperoxidase (MPO) is a myelocyte derived iron containing enzyme particularly involved in host defense by destroying foreign micro organisms invading the body.	Iron	57-61	myeloperoxidase	Homo sapiens	29-32
26373048-6	2015	Cytochrome c is adsorbed to graphene with the group heme lying almost perpendicular to the graphene, and the distance between Fe atom and the graphene is 10.15 A, which is shorter than that between electron donor and receptor in many other biosystems.	Iron	126-128	cytochrome c, somatic	Homo sapiens	0-12
26011561-0	2015	High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.	Iron	12-16	leucine rich repeat kinase 2	Homo sapiens	31-36
26011561-1	2015	OBJECTIVES: The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson"s disease (PD), using R2* relaxometry rate.	Iron	53-57	leucine rich repeat kinase 2	Homo sapiens	135-163
26055466-0	2015	Alzheimer disease: Iron--the missing link between ApoE and Alzheimer disease?	Iron	19-23	apolipoprotein E	Homo sapiens	50-54
26011561-1	2015	OBJECTIVES: The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson"s disease (PD), using R2* relaxometry rate.	Iron	53-57	leucine rich repeat kinase 2	Homo sapiens	165-170
26011561-8	2015	CONCLUSION: These results are consistent with increased iron load in LRRK2- and Parkin-mutation carriers.	Iron	56-60	leucine rich repeat kinase 2	Homo sapiens	69-74
26355253-4	2015	Although the exact pathophysiology of RLS is unknown, it is thought to involve an imbalance in iron metabolism and dopamine neurotransmission in the brain.	Iron	95-99	RLS1	Homo sapiens	38-41
26262699-17	2015	IV iron supplementation in iron-deficient patients (n = 9) increased hemoglobin (13.5 g/l +- 0.7), compared with the pre-op (12.8 g/l +- 1.2; p: 0.05), as well as transferrin saturation and ferritin.	Iron	3-7	transferrin	Homo sapiens	163-174
26089776-2	2015	Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF).	Iron	98-102	transferrin	Homo sapiens	80-91
25871543-6	2015	The data showed that the exposure of MxIRT1-eGFP-transformed wild-type and tor1  strains to excessive iron led to significantly increased levels of ATG8 transcript and ATG8-PE protein, which resulted in enhanced MxIRT1 degradation.	Iron	102-106	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	148-152
25871543-6	2015	The data showed that the exposure of MxIRT1-eGFP-transformed wild-type and tor1  strains to excessive iron led to significantly increased levels of ATG8 transcript and ATG8-PE protein, which resulted in enhanced MxIRT1 degradation.	Iron	102-106	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	168-172
25946517-3	2015	The present study aimed to examine the association between maternal Fe status during the first trimester of pregnancy, as assessed by serum ferritin, transferrin receptor and their ratio, with size at birth and preterm birth.	Iron	68-70	transferrin	Homo sapiens	150-161
26024204-0	2015	HYSCORE Analysis of the Effects of Substrates on Coordination of Water to the Active Site Iron in Tyrosine Hydroxylase.	Iron	90-94	tyrosine hydroxylase	Homo sapiens	98-118
25907691-2	2015	BMP and IL-6 signaling act via Smad and Stat3 transcription factors, respectively, to increase expression of hepcidin, the master regulator of iron metabolism.	Iron	143-147	interleukin 6	Rattus norvegicus	8-12
25907691-2	2015	BMP and IL-6 signaling act via Smad and Stat3 transcription factors, respectively, to increase expression of hepcidin, the master regulator of iron metabolism.	Iron	143-147	SMAD family member 7	Rattus norvegicus	31-35
25907691-2	2015	BMP and IL-6 signaling act via Smad and Stat3 transcription factors, respectively, to increase expression of hepcidin, the master regulator of iron metabolism.	Iron	143-147	hepcidin antimicrobial peptide	Rattus norvegicus	109-117
26106291-3	2015	DMT1 locates to cellular membranes and endosomal membranes, where it is a key player in non-transferrin bound iron uptake and transferrin-bound iron uptake, respectively.	Iron	144-148	transferrin	Homo sapiens	126-137
26106291-9	2015	This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol.	Iron	37-41	transferrin	Homo sapiens	79-90
26106291-9	2015	This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol.	Iron	37-41	transferrin	Homo sapiens	157-168
26106291-9	2015	This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol.	Iron	147-151	transferrin	Homo sapiens	157-168
26106291-9	2015	This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol.	Iron	147-151	transferrin	Homo sapiens	157-168
26106291-11	2015	The virtual absent expression of transferrin receptors and DMT1 in glial cells, i.e., astrocytes, microglia and oligodendrocytes, suggest that the steady state uptake of iron in glia is much lower than in neurons and/or other mechanisms for iron uptake in these cell types prevail.	Iron	170-174	transferrin	Homo sapiens	33-44
26089776-2	2015	Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF).	Iron	22-26	transferrin	Homo sapiens	80-91
26089776-2	2015	Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF).	Iron	22-26	transferrin	Homo sapiens	119-130
26089776-2	2015	Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF).	Iron	98-102	transferrin	Homo sapiens	80-91
26089776-2	2015	Accordingly, neuronal iron supply is tightly controlled: it depends not only on transferrin-bound iron but also on non-transferrin-bound iron (NTBI), which represents a relevant quote of the iron physiologically present in the cerebrospinal fluid (CSF).	Iron	98-102	transferrin	Homo sapiens	80-91
26016389-2	2015	In human mitochondria, the core Fe-S biosynthetic enzymatic complex (called SDUF) consists of NFS1, ISD11, ISCU2, and frataxin (FXN) protein components.	Iron	32-36	LYR motif containing 4	Homo sapiens	100-105
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	30-34	LYR motif containing 4	Homo sapiens	87-92
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	142-146	LYR motif containing 4	Homo sapiens	87-92
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	161-165	LYR motif containing 4	Homo sapiens	87-92
26057801-5	2015	THB1 resembles other TrHb1s, but also exhibits distinct features associated with the coordination of the heme iron by a histidine (proximal) and a lysine (distal).	Iron	110-114	uncharacterized protein	Chlamydomonas reinhardtii	0-4
26035688-1	2015	Lactoferrin (Lf) can bind to lactoferrin receptor (LfR), leading to iron transport through the plasma membrane.	Iron	68-72	intelectin 1 (galactofuranose binding)	Mus musculus	29-49
26035688-1	2015	Lactoferrin (Lf) can bind to lactoferrin receptor (LfR), leading to iron transport through the plasma membrane.	Iron	68-72	intelectin 1 (galactofuranose binding)	Mus musculus	51-54
26035688-9	2015	In ventral mesencephalon neurons, both iron-free Lf (apo-Lf) and iron-saturated Lf (holo-Lf) exerted neuroprotective effects against MPP(+) by mechanisms, believed to enhance the mitochondrial transmembrane potential, improve Cu/Zn-superoxide dismutase activity, increase Bcl-2 expression.	Iron	65-69	B cell leukemia/lymphoma 2	Mus musculus	272-277
25824831-6	2015	Infected mice have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.	Iron	56-60	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	70-83
25779881-0	2015	Monoclonal anti-transferrin antibody: a paradigm for better understanding of iron metabolism.	Iron	77-81	transferrin	Homo sapiens	16-27
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	6-8	cysteine desulfurase	Saccharomyces cerevisiae S288C	221-225
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	6-8	cysteine desulfurase	Saccharomyces cerevisiae S288C	221-225
25000850-14	2015	Induction of transferrin by H2O2, and consequently, decreased iron absorption, suggests a novel mechanism for iron deficiency in NASH patients.	Iron	62-66	transferrin	Homo sapiens	13-24
32262777-9	2015	Internalized nanoparticles released free iron complexes into the cytoplasm, which triggered ROS down-regulation and induced apoptosis through activating AKT and MAPKs pathways.	Iron	41-45	AKT serine/threonine kinase 1	Homo sapiens	153-156
25447544-0	2015	Anatomy of an iron-sulfur cluster scaffold protein: Understanding the determinants of [2Fe-2S] cluster stability on IscU.	Iron	14-18	iron-sulfur cluster assembly enzyme	Homo sapiens	116-120
25825391-3	2015	In pulmonary vascular cells and particularly endothelium, hypoxic induction of miR-210 and repression of the miR-210 targets ISCU1/2 down-regulated Fe-S levels.	Iron	148-152	microRNA 210	Mus musculus	109-116
25825391-6	2015	Mice deficient in miR-210, via genetic/pharmacologic means or via an endothelial-specific manner, displayed increased ISCU1/2 and were resistant to Fe-S-dependent pathophenotypes and PH.	Iron	148-152	microRNA 210	Mus musculus	18-25
25824831-6	2015	Infected mice have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.	Iron	129-133	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	70-83
25824831-9	2015	Tissue macrophage export of iron occurs concurrent with high serum concentrations of interferon gamma (IFN-gamma) and interleukin 12 (IL-12).	Iron	28-32	interferon gamma	Mus musculus	85-112
25792380-0	2015	Detailed molecular dynamics simulations of human transferrin provide insights into iron release dynamics at serum and endosomal pH.	Iron	83-87	transferrin	Homo sapiens	49-60
24990704-8	2015	The following predictors were found to be associated with EPO prescription: iron supplementation (odds ratio [OR] 52.70, 95% confidence interval [CI] 11.70-237.46), renal clinic appointment (OR 2.60, 95% CI 1.79-3.76), malignancy (OR 1.52, 95% CI 1.07-2.16) and use of hydralazine/nitrates (OR 1.41, 95% CI 1.03-1.92).	Iron	76-80	erythropoietin	Homo sapiens	58-61
25649872-4	2015	Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation.	Iron	163-167	transferrin	Rattus norvegicus	65-76
25649872-5	2015	In brain interstitial fluid, transferring-bound iron (TBI) and non-transferrin-bound iron (NTBI) exist as potential iron sources.	Iron	48-52	transferrin	Rattus norvegicus	29-40
25649872-4	2015	Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation.	Iron	163-167	transferrin	Rattus norvegicus	44-55
25649872-6	2015	Primary hippocampal neurons exhibit significant iron uptake from TBI (Transferrin-(59) Fe(3+)) and NTBI, whether presented as (59) Fe(2+) -citrate or (59) Fe(3+) -citrate; reductase-independent (59) Fe(2+) uptake was the most efficient uptake pathway of the three.	Iron	48-52	transferrin	Rattus norvegicus	70-81
25649872-13	2015	Zip8 and Steap2 are strongly expressed in the plasma membrane of both soma and processes, implying a crucial role in iron accumulation from NTBI and transferrin-bound iron (TBI) by hippocampal neurons.	Iron	167-171	transferrin	Rattus norvegicus	149-160
25698609-9	2015	The percentage of hypochromic red blood cells (r=0.52) and soluble transferrin receptor (r=0.59) value were significantly correlated to the Hb increase in patients receiving iron.	Iron	174-178	transferrin	Homo sapiens	67-78
26405511-11	2015	IFN-gamma and TNF-alpha have also been reported to work in concert with other factors such as nitric oxide and iron in order to induce anaemia.	Iron	111-115	interferon gamma	Mus musculus	0-9
26405511-11	2015	IFN-gamma and TNF-alpha have also been reported to work in concert with other factors such as nitric oxide and iron in order to induce anaemia.	Iron	111-115	tumor necrosis factor	Mus musculus	14-23
25672910-10	2015	NTE can protect the neuronal population in the hippocampal CA2 region by adjusting the expression of Fpn to balance iron levels following cerebral ischemia.	Iron	116-120	carbonic anhydrase 2	Rattus norvegicus	59-62
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-41	nuclear receptor coactivator 5	Homo sapiens	60-63
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	19-23	nuclear receptor coactivator 5	Homo sapiens	156-159
26024919-10	2015	Because activated microglia accumulate iron, we determined whether iron status influenced Sema4A and found that iron chelation decreased Sema4A and iron loading increased Sema4A in activated microglia.	Iron	67-71	semaphorin 4A	Homo sapiens	90-96
26024919-10	2015	Because activated microglia accumulate iron, we determined whether iron status influenced Sema4A and found that iron chelation decreased Sema4A and iron loading increased Sema4A in activated microglia.	Iron	67-71	semaphorin 4A	Homo sapiens	90-96
26024919-10	2015	Because activated microglia accumulate iron, we determined whether iron status influenced Sema4A and found that iron chelation decreased Sema4A and iron loading increased Sema4A in activated microglia.	Iron	67-71	semaphorin 4A	Homo sapiens	90-96
26024919-11	2015	Overall, our data implicate Sema4A in the destruction of OLs and reveal that its expression is sensitive to iron levels.	Iron	108-112	semaphorin 4A	Homo sapiens	28-34
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-39	nuclear receptor coactivator 5	Homo sapiens	60-63
25897079-4	2015	Here, we use XPD as a prototypical Fe-S protein to further characterize how Fe-S assembly is facilitated by the CIA targeting complex.	Iron	76-80	nuclear receptor coactivator 5	Homo sapiens	112-115
25897079-5	2015	Multiple lines of evidence indicate that this process occurs in a stepwise fashion in which XPD acquires a Fe-S cluster from the CIA targeting complex before assembling into TFIIH.	Iron	107-111	nuclear receptor coactivator 5	Homo sapiens	129-132
32262292-5	2015	Meanwhile, by integrating glucose oxidase on the Fe-Phen-CFs composite, sensitive detection of glucose is also achieved with a linear range from 0.5 to 200 muM and a limit of detection of 0.19 muM.	Iron	49-51	latexin	Homo sapiens	156-159
32262292-5	2015	Meanwhile, by integrating glucose oxidase on the Fe-Phen-CFs composite, sensitive detection of glucose is also achieved with a linear range from 0.5 to 200 muM and a limit of detection of 0.19 muM.	Iron	49-51	latexin	Homo sapiens	193-196
25501922-0	2015	Clinical significance of C-reactive protein levels in predicting responsiveness to iron therapy in patients with inflammatory bowel disease and iron deficiency anemia.	Iron	83-87	C-reactive protein	Homo sapiens	25-43
25839654-8	2015	Overall, our current study provides a novel molecular mechanism of BTG2-mediated induction of hepcidin gene expression, thereby contributing to a better understanding of the hepatic hepcidin production involved in iron homeostasis.	Iron	214-218	BTG anti-proliferation factor 2	Mus musculus	67-71
25849895-1	2015	Heme oxygenase (HO) catalyzes a key step in heme homeostasis: the O2- and NADPH-cytochrome P450 reductase-dependent conversion of heme to biliverdin, Fe, and CO through a process in which the heme participates both as a prosthetic group and as a substrate.	Iron	150-152	cytochrome p450 oxidoreductase	Homo sapiens	74-105
25934480-6	2015	In cases with brain amyloid pathology (n = 15, age = 78.7 +- 12.7 year), increased BACE1 IR was identified locally at capillaries, arterioles and along the pia, localizing to endothelia, perivascular dystrophic neurites and meningeal cells, and often coexisting with vascular iron deposition.	Iron	276-280	beta-secretase 1	Homo sapiens	83-88
28706676-7	2015	We find that wild types utilise ferritin to sustain longevity, buffering against exogenous iron and showing rapid ageing if ferritin is ablated.	Iron	91-95	Ferritin	Caenorhabditis elegans	32-40
28706676-8	2015	After reproduction, escape of iron from safe-storage in ferritin raised cellular Fe2+ load in the ageing C. elegans, and increased generation of reactive species.	Iron	30-34	Ferritin	Caenorhabditis elegans	56-64
25444086-2	2015	The purpose of this study is to examine the association of iron indices (serum ferritin and transferrin saturation) with risk of impaired fasting glucose and insulin resistance.	Iron	59-63	transferrin	Homo sapiens	92-103
25857330-6	2015	X-Band electron paramagnetic resonance spectroscopy of the {FeNO}(7) centers of the (Fe+NO+2OG) enzyme forms showed the presence of a more rhombic line shape in Thr(387)   Ala than in WT PHD2, indicating an altered conformation for bound gas in this variant.	Iron	60-62	egl-9 family hypoxia inducible factor 1	Homo sapiens	187-191
25802332-0	2015	Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium.	Iron	0-4	transforming growth factor beta 1	Homo sapiens	79-116
25802332-4	2015	Modulation of TGF-beta signaling, involving ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-delta, is responsible for iron-induced C3 expression.	Iron	120-124	transforming growth factor beta 1	Homo sapiens	14-22
25802332-4	2015	Modulation of TGF-beta signaling, involving ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-delta, is responsible for iron-induced C3 expression.	Iron	120-124	mitogen-activated protein kinase 3	Homo sapiens	44-50
25802332-6	2015	Pharmacologic inhibition of either ERK1/2 or SMAD3 phosphorylation decreased iron-induced C3 expression levels.	Iron	77-81	mitogen-activated protein kinase 3	Homo sapiens	35-41
25765487-5	2015	Here the syntheses and properties of bimetallic complexes [MFe(I) (trop2 dae)(solv)] (M=Na, solv=3 thf; M=Li, solv=2 Et2 O; trop=5H-dibenzo[a,d]cyclo-hepten-5-yl, dae=(N-CH2 -CH2 -N) with a d(7) Fe low-spin valence-electron configuration are reported.	Iron	60-62	tumor associated calcium signal transducer 2	Homo sapiens	67-72
25501922-11	2015	Among iron tablet-treated patients, Hb increase was significantly smaller in the high- versus low-CRP subgroup (1.1 vs. 2.0, 2.3 vs. 3.1, and 3.0 vs. 4.0 g/dL at weeks 2, 4, and 8, respectively; all p &lt; 0.05).	Iron	6-10	C-reactive protein	Homo sapiens	98-101
25501922-15	2015	CONCLUSIONS: Patients with high baseline CRP achieved a lower Hb response with oral iron therapy.	Iron	84-88	C-reactive protein	Homo sapiens	41-44
25682599-1	2015	Heme oxygenase-1 is critical for iron recycling during red blood cell turnover, whereas its impact on steady-state erythropoiesis and red blood cell lifespan is not known.	Iron	33-37	heme oxygenase 1	Mus musculus	0-16
25600403-8	2015	We also observed an increase in iron uptake and a decrease in transferrin receptor protein upon TXNIP overexpression, suggesting a role in iron homeostasis.	Iron	139-143	thioredoxin interacting protein	Mus musculus	96-101
25802005-0	2015	Erratum to: Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses.	Iron	132-136	transmembrane serine protease 6	Homo sapiens	68-100
25802005-0	2015	Erratum to: Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses.	Iron	132-136	transmembrane serine protease 6	Homo sapiens	102-109
25944634-0	2015	Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis.	Iron	46-50	transferrin	Homo sapiens	17-28
25809685-0	2015	Common Variants and Haplotypes in the TF, TNF-alpha, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population.	Iron	91-95	transferrin	Homo sapiens	38-40
25524401-1	2015	UNLABELLED: Iron is implicated in the pathogenesis of liver injury and insulin resistance (IR) and thus phlebotomy has been proposed as a treatment for nonalcoholic fatty liver disease (NAFLD).	Iron	12-16	insulin	Homo sapiens	71-78
25809685-0	2015	Common Variants and Haplotypes in the TF, TNF-alpha, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population.	Iron	91-95	tumor necrosis factor	Homo sapiens	42-51
25809685-0	2015	Common Variants and Haplotypes in the TF, TNF-alpha, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population.	Iron	91-95	transmembrane serine protease 6	Homo sapiens	57-64
25809685-8	2015	CONCLUSIONS: Various SNPs and allele combinations in the TF, TNF-alpha, and TMPRSS6 genes are associated with iron status in black South African women; however, these association patterns are different compared with European ancestry populations.	Iron	110-114	transferrin	Homo sapiens	57-59
25809685-8	2015	CONCLUSIONS: Various SNPs and allele combinations in the TF, TNF-alpha, and TMPRSS6 genes are associated with iron status in black South African women; however, these association patterns are different compared with European ancestry populations.	Iron	110-114	tumor necrosis factor	Homo sapiens	61-70
25809685-8	2015	CONCLUSIONS: Various SNPs and allele combinations in the TF, TNF-alpha, and TMPRSS6 genes are associated with iron status in black South African women; however, these association patterns are different compared with European ancestry populations.	Iron	110-114	transmembrane serine protease 6	Homo sapiens	76-83
25860622-0	2015	Iron-Catalyzed Oxidative C-H/C-H Cross-Coupling between Electron-Rich Arenes and Alkenes.	Iron	0-4	churchill domain containing 1	Homo sapiens	25-32
25565307-5	2015	In multivariate analyses adjusting for age and preoperative eGFR, patients in the highest compared with the lowest quartile of catalytic iron on postoperative day 1 had a 6.71 greater odds of experiencing the primary outcome, and also had greater odds of AKI, hospital mortality, and postoperative myocardial injury.	Iron	137-141	epidermal growth factor receptor	Homo sapiens	60-64
25691377-12	2015	A healthy neuron may tolerate free metal toxicity, such as iron in the case of injury-induced amyloid, for as long as twenty years due to this very BACE1 activity.	Iron	59-63	beta-secretase 1	Homo sapiens	148-153
25644541-4	2015	The antimicrobial activities and iron-binding behaviors of recombinant lactoferrin indicated that it was correctly folded and functional.	Iron	33-37	lactotransferrin	Ovis aries	71-82
25915509-1	2015	Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a form of Neurodegeneration with Brain Iron Accumulation (NBIA) associated with mutations in the pantothenate kinase 2 gene (PANK2).	Iron	98-102	pantothenate kinase 2	Homo sapiens	156-177
25915509-1	2015	Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a form of Neurodegeneration with Brain Iron Accumulation (NBIA) associated with mutations in the pantothenate kinase 2 gene (PANK2).	Iron	98-102	pantothenate kinase 2	Homo sapiens	184-189
25782468-12	2015	CONCLUSIONS: RAGE signaling is involved in blood-brain barrier and white matter fiber damage after ICH, the initiation of which is associated with iron.	Iron	147-151	advanced glycosylation end product-specific receptor	Rattus norvegicus	13-17
25898169-4	2015	Two functionally interacting Arabidopsis genes, LPR1 (ferroxidase) and PDR2 (P5-type ATPase), are key players in root Pi sensing, which is modified by iron (Fe) availability.	Iron	151-155	phosphate deficiency response 2	Arabidopsis thaliana	71-75
25896789-1	2015	BACKGROUND: Hepcidin is a peptide hormone belonging to the defensin family of cationic antimicrobial molecules that has an essential role in systemic iron homeostasis.	Iron	150-154	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
25896789-9	2015	Hepcidin co-localised with ferroportin in ependymal cells of the sub-ventricular zone and in the corpus callosum consistent with a regulatory role in iron metabolism at these sites.	Iron	150-154	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
25651456-5	2015	Similarly, according to the predicted binding orientation in the active site of the crystal structure of human CYP3A4 (PDB code: 4I4G ), the alkaloids were positioned in such a way that the C3 atom of lasiocarpine and retrorsine and the C26 of senkirkin were closest to the catalytic heme Fe.	Iron	289-291	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-117
25654270-1	2015	Iron in iron overload disease is present as non-transferrin-bound iron, consisting of iron, citrate, and albumin.	Iron	0-4	transferrin	Homo sapiens	48-59
25654270-1	2015	Iron in iron overload disease is present as non-transferrin-bound iron, consisting of iron, citrate, and albumin.	Iron	8-12	transferrin	Homo sapiens	48-59
25826707-0	2015	Mg(OH)2 Supported Nanoscale Zero Valent Iron Enhancing the Removal of Pb(II) from Aqueous Solution.	Iron	40-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	70-76
25826707-5	2015	Mechanisms were also explored by a comparative study of the phase, morphology, and surface valence state of composite before and after reaction, indicating that at least three paths are involved in the synergistic removal process: (1) Pb(II) adsorption by Mg(OH)2 (companied with ion exchange reaction); (2) Pb(II) reduction to Pb0 by nanoscale zerovalent iron; and (3) Pb(II) precipitation as Pb(OH)2.	Iron	356-360	submaxillary gland androgen regulated protein 3B	Homo sapiens	235-241
25826707-6	2015	The hydroxies provided by Mg(OH)2 can dramatically promote the role of nanoscale zerovalent iron as reducer, thus greatly enhancing the whole Pb(II) sequestration process.	Iron	92-96	submaxillary gland androgen regulated protein 3B	Homo sapiens	142-148
25798458-3	2015	Oxidation of heme iron was observed from the disappearance of the Q band in the UV-vis spectra of Cyt c upon [Cho][AOT] binding above C3.	Iron	18-22	cytochrome c, somatic	Homo sapiens	98-103
25898169-4	2015	Two functionally interacting Arabidopsis genes, LPR1 (ferroxidase) and PDR2 (P5-type ATPase), are key players in root Pi sensing, which is modified by iron (Fe) availability.	Iron	157-159	phosphate deficiency response 2	Arabidopsis thaliana	71-75
25898169-5	2015	We show that the LPR1-PDR2 module facilitates, upon Pi limitation, cell-specific apoplastic Fe and callose deposition in the meristem and elongation zone of primary roots.	Iron	92-94	phosphate deficiency response 2	Arabidopsis thaliana	22-26
24909164-0	2015	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.	Iron	25-29	sirtuin 3	Homo sapiens	0-5
24909164-5	2015	As a consequence, IRP1 target genes, such as the transferrin receptor (TfR1), a membrane-associated glycoprotein critical for iron uptake and cell proliferation, are controlled by SIRT3.	Iron	126-130	sirtuin 3	Homo sapiens	180-185
24909164-7	2015	SIRT3 null cells contain high levels of iron and lose iron-dependent TfR1 regulation.	Iron	40-44	sirtuin 3	Homo sapiens	0-5
24909164-3	2015	Here, we report that mitochondrial SIRT3 regulates cellular iron metabolism by modulating IRP1 activity.	Iron	60-64	sirtuin 3	Homo sapiens	35-40
24909164-7	2015	SIRT3 null cells contain high levels of iron and lose iron-dependent TfR1 regulation.	Iron	54-58	sirtuin 3	Homo sapiens	0-5
25590823-2	2015	Mobilization of As(V) strongly depended on the S(-II):Fe ratio and the amount of As(V) loading on ferrihydrite.	Iron	54-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	16-21
24909164-9	2015	We found that the regulation of iron uptake and TfR1 expression contribute to the tumor-suppressive activity of SIRT3.	Iron	32-36	sirtuin 3	Homo sapiens	112-117
24909164-12	2015	Our data uncover a novel role of SIRT3 in cellular iron metabolism through IRP1 regulation and suggest that SIRT3 functions as a tumor suppressor, in part, by modulating cellular iron metabolism.	Iron	51-55	sirtuin 3	Homo sapiens	33-38
24909164-12	2015	Our data uncover a novel role of SIRT3 in cellular iron metabolism through IRP1 regulation and suggest that SIRT3 functions as a tumor suppressor, in part, by modulating cellular iron metabolism.	Iron	179-183	sirtuin 3	Homo sapiens	108-113
25867633-0	2015	Iron-hepcidin dysmetabolism, anemia and renal hypoxia, inflammation and fibrosis in the remnant kidney rat model.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
25967301-4	2015	With renewed interest in the MLT-X region prompted by recent lidar discoveries of Fe in the thermosphere reaching 170 km at McMurdo, Antarctica, the receiver optimizations we have made now enable addressing an important need in the community.	Iron	82-84	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	29-32
25590823-3	2015	High S(-II):Fe ratio caused a more complete dissolution of ferrihydrite and a large fraction of As(V) could be released into solution.	Iron	12-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	96-101
25590823-4	2015	The percentages of the released As(V) were 2.5% and 7.5% at S(-II):Fe ratios of 0.240 and 24.0, respectively, at pH 6.1, while the released As(V) were 5.5%, 16.3% at pH 8.0 under similar conditions.	Iron	67-69	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-37
25590823-7	2015	During the dissolution, secondary minerals such as goethite, magnetite and FeS were detected and played different roles in the mobilization of As(V).	Iron	75-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	143-148
25835505-6	2015	These include competition with chloride, the natural co-substrate; switching the MPO activity from a two electron oxidation to a one electron pathway causing the buildup of the inactive Compound II, and its subsequent decay to MPO-Fe(III) instead of generating HOCl; binding to MPO above the heme iron, thereby preventing the access of H2O2 to the catalytic site of the enzyme; and direct scavenging of HOCl.	Iron	297-301	myeloperoxidase	Homo sapiens	81-84
25267079-0	2015	Iron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: the CODAM study.	Iron	0-4	insulin	Homo sapiens	49-56
25267079-1	2015	OBJECTIVES: Several markers of iron metabolism have been associated with insulin resistance (IR) and type 2 diabetes mellitus in cross-sectional studies.	Iron	31-35	insulin	Homo sapiens	73-80
28357284-0	2015	Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism.	Iron	111-115	Coenzyme A synthase	Homo sapiens	15-34
25835505-1	2015	Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron.	Iron	188-192	myeloperoxidase	Homo sapiens	0-15
25835505-1	2015	Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron.	Iron	188-192	myeloperoxidase	Homo sapiens	17-20
25835505-1	2015	Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron.	Iron	188-192	myeloperoxidase	Homo sapiens	104-107
25588876-1	2015	Mutations in the TMPRSS6 gene are associated with severe iron-refractory iron deficiency anemia resulting from an overexpression of hepcidin, the key regulator of iron homeostasis.	Iron	57-61	transmembrane serine protease 6	Homo sapiens	17-24
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	126-130	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	193-206
25636453-2	2015	For diagnostic purposes iron-related parameters in patients are assessed by clinical chemical blood analysis including the analysis of ferritin, transferrin and iron levels.	Iron	24-28	transferrin	Homo sapiens	145-156
25557470-0	2015	The role of TMPRSS6 polymorphisms in iron deficiency anemia partially responsive to oral iron treatment.	Iron	37-41	transmembrane serine protease 6	Homo sapiens	12-19
25557470-1	2015	Iron refractory iron deficiency anemia (IRIDA) is a rare hereditary disease caused by mutations in TMPRSS6 gene encoding Matriptase-2, a negative regulator of hepcidin transcription.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	99-106
25557470-1	2015	Iron refractory iron deficiency anemia (IRIDA) is a rare hereditary disease caused by mutations in TMPRSS6 gene encoding Matriptase-2, a negative regulator of hepcidin transcription.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	121-133
25557470-3	2015	TMPRSS6 polymorphisms are more frequent than mutations, and have been associated with variation in iron and hematologic parameters.	Iron	99-103	transmembrane serine protease 6	Homo sapiens	0-7
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	40-44	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	208-212
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	126-130	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	208-212
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	40-44	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	193-206
25700647-11	2015	Low risk patients (IPSS low and int-1) mainly receive supportive therapy including iron chelation.	Iron	83-87	Wnt family member 1	Homo sapiens	32-37
25614087-2	2015	In animals, we have shown that maternal iron deficiency is minimised in the foetus by increased expression of placental transferrin receptor (pTFR1), resulting in increased iron transfer at the expense of maternal iron stores.	Iron	40-44	transferrin	Homo sapiens	120-131
25614087-2	2015	In animals, we have shown that maternal iron deficiency is minimised in the foetus by increased expression of placental transferrin receptor (pTFR1), resulting in increased iron transfer at the expense of maternal iron stores.	Iron	173-177	transferrin	Homo sapiens	120-131
25614087-6	2015	Maternal iron status was measured by determining serum transferrin receptor (sTFR) and ferritin levels at 24 and 34 weeks and at delivery.	Iron	9-13	transferrin	Homo sapiens	55-66
25575693-8	2015	We conclude that in AD damage occurs in conjunction with iron accumulation, and the brain iron load associated with loss control of the brain iron metabolism related protein DMT1 and FPN1 expressions.	Iron	90-94	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	183-187
26411103-1	2015	BACKGROUND: Insulin resistance is positively correlated with body iron.	Iron	66-70	insulin	Homo sapiens	12-19
26411103-5	2015	The present study was designed to compare and correlate insulin resistance with iron parameters (including serum ferritin, transferrin saturation and blood haemoglobin) in non-diabetic offspring of type 2 diabetics and non-diabetic offspring of non-diabetics.	Iron	80-84	insulin	Homo sapiens	56-63
26411103-12	2015	There was significant positive correlation (p=0.027) between insulin resistance and serum iron in non-diabetic offspring of type 2 diabetics.	Iron	90-94	insulin	Homo sapiens	61-68
26411103-13	2015	There was also significant positive correlation between insulin resistance and serum iron, transferrin saturation and haemoglobin in non-diabetic offspring of non-diabetics.	Iron	85-89	insulin	Homo sapiens	56-63
25467855-5	2015	Iron mediates electron transfer as an essential component of e.g. myeloperoxidase, hemoglobin, cytochrome C and ribonucleotide reductase.	Iron	0-4	myeloperoxidase	Homo sapiens	66-81
25467855-5	2015	Iron mediates electron transfer as an essential component of e.g. myeloperoxidase, hemoglobin, cytochrome C and ribonucleotide reductase.	Iron	0-4	cytochrome c, somatic	Homo sapiens	95-107
25537134-3	2015	We find the zero-field splitting to be a sensitive probe of the structure of the transferrin iron-binding sites.	Iron	93-97	transferrin	Homo sapiens	81-92
25537134-4	2015	Signals arising from iron bound to the transferrin N-lobe can clearly be distinguished from signals from iron bound to the C-lobe.	Iron	21-25	transferrin	Homo sapiens	39-50
25537134-4	2015	Signals arising from iron bound to the transferrin N-lobe can clearly be distinguished from signals from iron bound to the C-lobe.	Iron	105-109	transferrin	Homo sapiens	39-50
24813452-7	2015	Fe status was determined by hemoglobin (Hb), mean corpuscular volume, serum Fe, total iron binding capacity, transferrin saturation, erythrocyte Zn protoporphyrin and serum ferritin (SF).	Iron	0-2	transferrin	Homo sapiens	109-120
25575693-8	2015	We conclude that in AD damage occurs in conjunction with iron accumulation, and the brain iron load associated with loss control of the brain iron metabolism related protein DMT1 and FPN1 expressions.	Iron	90-94	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	183-187
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Iron	55-59	ferritin mitochondrial	Mus musculus	118-128
25706908-6	2015	The C N stretching mode of the incorporated pCNF detected in the IR spectra reveals a surprising difference, which is related to the oxidation state of the heme iron, thus indicating high sensitivity to changes in the electrostatics of cyt c.	Iron	161-165	cytochrome c, somatic	Homo sapiens	236-241
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Iron	194-198	ferritin mitochondrial	Mus musculus	118-128
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Iron	194-198	ferritin mitochondrial	Mus musculus	297-307
25641898-8	2015	To obtain biological insight into Zn and Fe cross-talk, we focused on transporters, where STP4 and STP13 sugar transporters were predominantly expressed and responsive to Fe-deficient conditions.	Iron	41-43	Major facilitator superfamily protein	Arabidopsis thaliana	99-104
25641898-8	2015	To obtain biological insight into Zn and Fe cross-talk, we focused on transporters, where STP4 and STP13 sugar transporters were predominantly expressed and responsive to Fe-deficient conditions.	Iron	171-173	sugar transporter 4	Arabidopsis thaliana	90-94
25641898-8	2015	To obtain biological insight into Zn and Fe cross-talk, we focused on transporters, where STP4 and STP13 sugar transporters were predominantly expressed and responsive to Fe-deficient conditions.	Iron	171-173	Major facilitator superfamily protein	Arabidopsis thaliana	99-104
25152462-8	2015	This indicates that iron may be the key stimulus that activates the Wnt signaling pathway and regulates subarachnoid fibrosis after cerebral hemorrhage, and that DFX may be a candidate for preventing PHCH in patients with IVH.	Iron	20-24	Wnt family member 1	Homo sapiens	68-71
25822525-4	2015	Cardiac iron overload resulted in increased oxidative stress and gene expression of the inflammatory mediators tumor necrosis factor-alpha, interleukin-10 and interferon gamma, as well as matrix metalloproteinases-2 and -9.	Iron	8-12	tumor necrosis factor	Rattus norvegicus	111-138
25714024-6	2015	Interfering with the integrity of the endoperoxide moiety of DHA and X-11, as well as chelating intracellular iron with deferoxamine, diminish apoptosis and Noxa induction.	Iron	110-114	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	157-161
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Iron	55-59	ferritin mitochondrial	Mus musculus	297-307
25714024-0	2015	Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety.	Iron	121-125	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	89-93
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Iron	194-198	ferritin mitochondrial	Mus musculus	118-128
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Iron	194-198	ferritin mitochondrial	Mus musculus	297-307
25714024-8	2015	DHA and X-11 represent a new group of AML cells-apoptosis inducing compounds which work through Noxa up-regulation utilizing the specific endoperoxide moiety and intracellular iron.	Iron	176-180	amyloid beta precursor protein binding family A member 1	Homo sapiens	8-12
25714024-8	2015	DHA and X-11 represent a new group of AML cells-apoptosis inducing compounds which work through Noxa up-regulation utilizing the specific endoperoxide moiety and intracellular iron.	Iron	176-180	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	96-100
25457201-9	2015	Both serum transferrin and iron levels were associated with serum ferritin levels, amount of iron removed and global clinical stage (p&lt;0.01).	Iron	93-97	transferrin	Homo sapiens	11-22
25588002-0	2015	Decreased plasma iron in Alzheimer"s disease is due to transferrin desaturation.	Iron	17-21	transferrin	Homo sapiens	55-66
25588002-4	2015	We found a significant decrease in transferrin-associated iron in AD that was missed by routine pathological tests of transferrin saturation, and that was able to discriminate between AD and controls.	Iron	58-62	transferrin	Homo sapiens	35-46
25588002-4	2015	We found a significant decrease in transferrin-associated iron in AD that was missed by routine pathological tests of transferrin saturation, and that was able to discriminate between AD and controls.	Iron	58-62	transferrin	Homo sapiens	118-129
25588002-5	2015	The AD cases showed no significant difference in transferrin concentration, only a decrease in total transferrin-bound iron.	Iron	119-123	transferrin	Homo sapiens	101-112
25588002-6	2015	These findings support that a previously identified decrease in plasma iron levels in AD patients within the AIBL study is attributable to decreased loading of iron into transferrin, and that this subtle but discriminatory change is not observed through routine pathological testing.	Iron	71-75	transferrin	Homo sapiens	170-181
25588002-6	2015	These findings support that a previously identified decrease in plasma iron levels in AD patients within the AIBL study is attributable to decreased loading of iron into transferrin, and that this subtle but discriminatory change is not observed through routine pathological testing.	Iron	160-164	transferrin	Homo sapiens	170-181
25291189-4	2015	To address this issue, we altered the levels of cellular iron in primary CD4(+) T cells and showed that higher iron is associated with increased HIV infection and replication.	Iron	57-61	CD4 molecule	Homo sapiens	73-76
25291189-4	2015	To address this issue, we altered the levels of cellular iron in primary CD4(+) T cells and showed that higher iron is associated with increased HIV infection and replication.	Iron	111-115	CD4 molecule	Homo sapiens	73-76
25526737-7	2015	SR, especially high-energy (56)Fe or (28)Si ions markedly decreased sphingosine-1-phosphate levels and Akt- and p38 MAPK phosphorylation, depleted anti-senescence sirtuin-1 and increased biochemical markers of autophagy.	Iron	31-33	thymoma viral proto-oncogene 1	Mus musculus	103-106
24712887-1	2015	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder characterized by iron accumulation in the brain, because of mutations in the PANK2 gene.	Iron	108-112	pantothenate kinase 2	Homo sapiens	0-48
24712887-1	2015	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder characterized by iron accumulation in the brain, because of mutations in the PANK2 gene.	Iron	108-112	pantothenate kinase 2	Homo sapiens	50-54
24712887-1	2015	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder characterized by iron accumulation in the brain, because of mutations in the PANK2 gene.	Iron	108-112	pantothenate kinase 2	Homo sapiens	168-173
25504030-1	2015	OBJECTIVE: A common variant rs236918 in the PCSK7 gene has the strongest association with iron homeostasis and is related to insulin resistance.	Iron	90-94	proprotein convertase subtilisin/kexin type 7	Homo sapiens	44-49
25504030-1	2015	OBJECTIVE: A common variant rs236918 in the PCSK7 gene has the strongest association with iron homeostasis and is related to insulin resistance.	Iron	90-94	insulin	Homo sapiens	125-132
25425685-0	2015	Rapid elevation of transferrin saturation and serum hepcidin concentration in hemodialysis patients after intravenous iron infusion.	Iron	118-122	transferrin	Homo sapiens	19-30
25547790-1	2015	Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth and survival.	Iron	217-221	transferrin	Homo sapiens	232-243
25211009-2	2015	Recent studies show that heme binds to the His residue of Abeta with the iron center and subsequently forms an Abeta-heme complex, which can inhibit Abeta aggregation.	Iron	73-77	amyloid beta precursor protein	Homo sapiens	58-63
25211009-2	2015	Recent studies show that heme binds to the His residue of Abeta with the iron center and subsequently forms an Abeta-heme complex, which can inhibit Abeta aggregation.	Iron	73-77	amyloid beta precursor protein	Homo sapiens	111-116
25804229-7	2015	RESULTS: Unregulated generation of superoxide radicals and NO by mitochondria of tumor cells and NADPH-oxidase and iNOS neutrophils via oxidation of iron-containing proteins causes the accumulation of "free iron" complexes in blood and tumor tissue of rats able to evoke oxide-induced damages of macromolecules.	Iron	149-153	nitric oxide synthase 2	Rattus norvegicus	115-119
25804229-7	2015	RESULTS: Unregulated generation of superoxide radicals and NO by mitochondria of tumor cells and NADPH-oxidase and iNOS neutrophils via oxidation of iron-containing proteins causes the accumulation of "free iron" complexes in blood and tumor tissue of rats able to evoke oxide-induced damages of macromolecules.	Iron	207-211	nitric oxide synthase 2	Rattus norvegicus	115-119
25594146-5	2015	RESULTS: In FSECs treated with catalytic iron for up to 6 days, we observed an increase in cell viability, NO production, and p53, pan-Ras, ERK/MAPK, PI3K/Akt, Ki67, and c-Myc activations (P &lt; 0.05) in a dose-dependent and time-dependent manner.	Iron	41-45	tumor protein p53	Homo sapiens	126-129
25594146-5	2015	RESULTS: In FSECs treated with catalytic iron for up to 6 days, we observed an increase in cell viability, NO production, and p53, pan-Ras, ERK/MAPK, PI3K/Akt, Ki67, and c-Myc activations (P &lt; 0.05) in a dose-dependent and time-dependent manner.	Iron	41-45	mitogen-activated protein kinase 1	Homo sapiens	140-143
25594146-5	2015	RESULTS: In FSECs treated with catalytic iron for up to 6 days, we observed an increase in cell viability, NO production, and p53, pan-Ras, ERK/MAPK, PI3K/Akt, Ki67, and c-Myc activations (P &lt; 0.05) in a dose-dependent and time-dependent manner.	Iron	41-45	AKT serine/threonine kinase 1	Homo sapiens	155-158
25318588-13	2015	Hepcidin or enterocyte iron levels may be involved in the regulation of age-dependent FPN1, DMT1, and DcytB expression in the duodenum.	Iron	23-27	solute carrier family 40 member 1	Rattus norvegicus	86-90
24803010-5	2015	A statistically significant association was found between HIF-1alpha immunoreactivity and hematocrit (p &lt; 0.001), hemoglobin (p &lt; 0.001), MCV (p &lt; 0.001), transferrin (p &lt; 0.001) and its receptors (p = 0.040), whereas no significant correlations were observed between HIF-1alpha, iron serum levels (p = 0.256) and ferritin (p = 0.232).	Iron	292-296	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68
25624148-5	2015	Fe excess decreases primary root length in the same way in wild-type and in fer1-3-4 mutant.	Iron	0-2	ferretin 1	Arabidopsis thaliana	76-80
25624148-6	2015	In contrast, the Fe-mediated decrease of lateral root (LR) length and density is enhanced in fer1-3-4 plants due to a defect in LR emergence.	Iron	17-19	ferretin 1	Arabidopsis thaliana	93-97
25624148-7	2015	We observe that this interaction between excess Fe, ferritin, and root system architecture (RSA) is in part mediated by the H2O2/O2 - balance between the root cell proliferation and differentiation zones regulated by the UPB1 transcription factor.	Iron	48-50	transcription factor UPBEAT protein	Arabidopsis thaliana	221-225
25530083-2	2015	The visualization of amyloid-beta (Abeta) plaques with MRI has largely been credited to rapid proton relaxation in the vicinity of plaques as a result of focal iron deposition.	Iron	160-164	amyloid beta precursor protein	Homo sapiens	21-33
25530083-3	2015	The goal of this work was to determine the relationship between local relaxation and related focal iron content associated with Abeta plaques.	Iron	99-103	amyloid beta precursor protein	Homo sapiens	128-133
25530083-2	2015	The visualization of amyloid-beta (Abeta) plaques with MRI has largely been credited to rapid proton relaxation in the vicinity of plaques as a result of focal iron deposition.	Iron	160-164	amyloid beta precursor protein	Homo sapiens	35-40
25530083-7	2015	The transverse relaxation rate associated with amyloid plaques was determined not to be solely a result of iron load, as much of the relaxation associated with Abeta plaques remained following iron chelation.	Iron	193-197	amyloid beta precursor protein	Homo sapiens	160-165
25825542-0	2015	Iron depletion results in Src kinase inhibition with associated cell cycle arrest in neuroblastoma cells.	Iron	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	26-29
25530083-8	2015	The data indicate a dual relaxation mechanism associated with Abeta plaques, such that iron and plaque composition synergistically produce transverse relaxation.	Iron	87-91	amyloid beta precursor protein	Homo sapiens	62-67
25825542-4	2015	Initial studies showed in the presence of DFO, these cells have high levels of p27 and after reversal of iron chelation p27 is degraded allowing for CDK2 kinase activity.	Iron	105-109	dynactin subunit 6	Homo sapiens	120-123
25825542-8	2015	For the first time therefore we show that iron chelation inhibits Src kinase activity and this activity is a requirement for cellular proliferation.	Iron	42-46	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	66-69
25645023-7	2015	Importantly, assembly of the Fe-S cluster in Pri2 is impaired not only by mutations at the conserved cysteine ligands but also by increased oxidative stress in the sod1Delta mutant lacking the Cu/Zn superoxide dismutase.	Iron	29-33	superoxide dismutase 1	Homo sapiens	193-219
25036750-8	2015	Here, we demonstrate that elevated iron concentration can drastically accelerate the differentiation of human embryonic stem cells (hESCs) toward motor neuron lineage potentially via a transferrin mediated pathway.	Iron	35-39	transferrin	Homo sapiens	185-196
25520048-8	2015	Decreased levels of adiponectin, macrophage-mediated inflammation, and ROS-mediated liver kinase B1 (LKB1)/adenosine monophosphate-activated protein kinase (AMPK) activation can contribute to iron overload-induced insulin resistance, whereas iron deficiency could also participate in obesity-related inflammation, hypoxia, and insulin resistance.	Iron	192-196	serine/threonine kinase 11	Mus musculus	84-99
25520048-8	2015	Decreased levels of adiponectin, macrophage-mediated inflammation, and ROS-mediated liver kinase B1 (LKB1)/adenosine monophosphate-activated protein kinase (AMPK) activation can contribute to iron overload-induced insulin resistance, whereas iron deficiency could also participate in obesity-related inflammation, hypoxia, and insulin resistance.	Iron	192-196	serine/threonine kinase 11	Mus musculus	101-105
26268875-7	2015	CONCLUSION: Fpn1 gene expression is inhibited in the duodenum of diet-induced obesity mouse while DMT1 expression keeps unchanged, and this implies that decreased iron export from enterocytes into circulation might be responsible for the impaired iron absorption in obesity.	Iron	163-167	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	12-16
26268875-7	2015	CONCLUSION: Fpn1 gene expression is inhibited in the duodenum of diet-induced obesity mouse while DMT1 expression keeps unchanged, and this implies that decreased iron export from enterocytes into circulation might be responsible for the impaired iron absorption in obesity.	Iron	247-251	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	12-16
25729473-1	2015	Elevated iron stores as indicated by hyperferritinemia with normal or mildly elevated transferrin saturation and mostly mild hepatic iron deposition are a characteristic finding in subjects with non-alcoholic fatty liver disease (NAFLD).	Iron	9-13	transferrin	Homo sapiens	86-97
25668700-13	2015	For example, the oxidative degradation of N- and S-bearing contaminants by Fe(VI) yields either Fe(II) or Fe(III) via the intermediacy of Fe(IV) and Fe(V) species, respectively (e.g., Fe(VI)   Fe(IV)   Fe(II) and Fe(VI)   Fe(V)   Fe(III)).	Iron	75-77	FEV transcription factor, ETS family member	Homo sapiens	149-154
25576700-4	2015	Hepcidin, an iron modulator, is involved in the inflammation process as well as iron homeostasis.	Iron	13-17	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
25576700-4	2015	Hepcidin, an iron modulator, is involved in the inflammation process as well as iron homeostasis.	Iron	80-84	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
25745543-0	2015	Liver Iron Concentration and Liver Impairment in Relation to Serum IGF-1 Levels in Thalassaemia Major Patients: A Retrospective Study.	Iron	6-10	insulin like growth factor 1	Homo sapiens	67-72
25668700-13	2015	For example, the oxidative degradation of N- and S-bearing contaminants by Fe(VI) yields either Fe(II) or Fe(III) via the intermediacy of Fe(IV) and Fe(V) species, respectively (e.g., Fe(VI)   Fe(IV)   Fe(II) and Fe(VI)   Fe(V)   Fe(III)).	Iron	75-77	FEV transcription factor, ETS family member	Homo sapiens	222-227
25821678-8	2015	The PLLA-Fe particle showed a significant increase in the IL-8 release in hMSCs but not in hHSCs.	Iron	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
25632988-3	2015	With M = Fe, Co, or Ni, electrochemical formation of the Ta-Ta bonds is accompanied by a partial reduction of the Fe(II), Co(II), or Ni(II) to Fe(0), Co(0), or Ni(0).	Iron	9-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
25646428-4	2015	Based on kinetic experiments on the O-O bond splitting transition of the catalytic cycle (A   P(R)), it has been proposed that the electron transfer to the binuclear iron-copper center of O2 reduction initiates the proton pump mechanism.	Iron	166-170	LDL receptor related protein 1	Homo sapiens	90-98
25592411-0	2015	Analysis of the C19orf12 and WDR45 genes in patients with neurodegeneration with brain iron accumulation.	Iron	87-91	WD repeat domain 45	Homo sapiens	29-34
25550162-0	2015	Low intracellular iron increases the stability of matriptase-2.	Iron	18-22	transmembrane serine protease 6	Homo sapiens	50-62
25550162-4	2015	Here, we report that MT2 is up-regulated under iron deprivation.	Iron	47-51	transmembrane serine protease 6	Homo sapiens	21-24
25550162-7	2015	Rather, studies using a membrane-permeable iron chelator, salicylaldehyde isonicotinoyl hydrazone, revealed that depletion of cellular iron was able to decrease the degradation of MT2 independently of internalization.	Iron	43-47	transmembrane serine protease 6	Homo sapiens	180-183
25550162-7	2015	Rather, studies using a membrane-permeable iron chelator, salicylaldehyde isonicotinoyl hydrazone, revealed that depletion of cellular iron was able to decrease the degradation of MT2 independently of internalization.	Iron	135-139	transmembrane serine protease 6	Homo sapiens	180-183
25550162-8	2015	We found that lack of the putative endocytosis motif in its cytoplasmic domain largely abolished the sensitivity of MT2 to iron depletion.	Iron	123-127	transmembrane serine protease 6	Homo sapiens	116-119
25686037-6	2015	In [Fe(PM-BiA)2(NCS)2], by combining DFT and classical molecular dynamics, the properties and the domains of existence of the different phases are obtained by expressing the potential energy surfaces in a short range potential for Fe-N interactions.	Iron	231-235	cytosolic thiouridylase subunit 2	Homo sapiens	16-21
25651183-5	2015	Mitochondrial iron accumulation is shown to depend on mitochondrial dysfunction and heme-dependent upregulation of the mitochondrial iron importer mitoferrin-2.	Iron	14-18	solute carrier family 25, member 28	Mus musculus	147-159
25651183-5	2015	Mitochondrial iron accumulation is shown to depend on mitochondrial dysfunction and heme-dependent upregulation of the mitochondrial iron importer mitoferrin-2.	Iron	133-137	solute carrier family 25, member 28	Mus musculus	147-159
25500022-6	2015	The NF-kappaB inhibitor [5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide (TPCA-1), which inhibits IKKbeta, the kinase of IkappaBalpha (inhibitory protein of NF-kappaB), was used to prevent iron overload-stimulated NF-kappaB changes in ESCs.	Iron	194-198	nuclear factor kappa B subunit 1	Homo sapiens	4-13
25316302-6	2015	Structural differences of the oxidized inactive [NiFe] cofactor of MBHs in the Ni-B state compared to PHs in the Ni-A state included a ~0.05 A longer Ni-O bond, a two times larger spread of the Ni-S bond lengths, and a ~0.1 A shorter Ni-Fe distance.	Iron	51-53	solute carrier family 5 member 5	Homo sapiens	194-198
25326244-11	2015	Ascorbic acid reduces transferrin-chelatable iron from ferric carboxymaltose, thus effects on hepcidin expression should be investigated in clinical studies.	Iron	45-49	transferrin	Homo sapiens	22-33
25271366-0	2015	The oral iron chelator deferasirox inhibits NF-kappaB mediated gene expression without impacting on proximal activation: implications for myelodysplasia and aplastic anaemia.	Iron	9-13	nuclear factor kappa B subunit 1	Homo sapiens	44-53
25413880-9	2015	Therefore, Zn deficiency resulted in insulin resistance through iron overload.	Iron	64-68	insulin	Homo sapiens	37-44
25413880-13	2015	These data suggest that, in patients with CLD-C, Zn deficiency promotes insulin resistance by exacerbating iron overload in the liver and induces hepatic steatosis by facilitating lipid peroxidation.	Iron	107-111	insulin	Homo sapiens	72-79
25486930-0	2015	Hereditary hypotransferrinemia can lead to elevated transferrin saturation and, when associated to HFE or HAMP mutations, to iron overload.	Iron	125-129	transferrin	Homo sapiens	15-26
25486930-4	2015	These cases emphasize the usefulness of serum transferrin determination in the diagnostic evaluation of iron overload and the importance for clinicians to be aware of this syndrome.	Iron	104-108	transferrin	Homo sapiens	46-57
25419642-7	2015	In cirrhotic patients, the serum iron and ferritin levels correlated positively with serum alanine transaminase levels and the transferrin levels were inversely related to both end-stage liver disease scores and iron levels (all P &lt; 0.01).	Iron	212-216	transferrin	Homo sapiens	127-138
25500022-0	2015	Iron overload-modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis.	Iron	0-4	nuclear factor kappa B subunit 1	Homo sapiens	24-46
25500022-1	2015	OBJECTIVE: To evaluate the effect of iron overload on nuclear factor kappa-B (NF-kappaB) activation in human endometrial stromal cells (ESCs).	Iron	37-41	nuclear factor kappa B subunit 1	Homo sapiens	54-76
25500022-1	2015	OBJECTIVE: To evaluate the effect of iron overload on nuclear factor kappa-B (NF-kappaB) activation in human endometrial stromal cells (ESCs).	Iron	37-41	nuclear factor kappa B subunit 1	Homo sapiens	78-87
25500022-6	2015	The NF-kappaB inhibitor [5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide (TPCA-1), which inhibits IKKbeta, the kinase of IkappaBalpha (inhibitory protein of NF-kappaB), was used to prevent iron overload-stimulated NF-kappaB changes in ESCs.	Iron	194-198	NFKB inhibitor alpha	Homo sapiens	126-138
25500022-10	2015	RESULT(S): Iron overload increased p65:DNA-binding activity and decreased IkappaBalpha and p65 cytoplasmic expression in ESCs after 30 minutes of incubation as compared with the basal condition.	Iron	11-15	NFKB inhibitor alpha	Homo sapiens	74-86
25500022-12	2015	TPCA-1 prevented the iron overload-induced increase of p65:DNA binding and IkappaBalpha degradation.	Iron	21-25	NFKB inhibitor alpha	Homo sapiens	75-87
25500022-13	2015	CONCLUSION(S): Iron overload activates IKKbeta in ESCs, stimulating the NF-kappaB pathway and increasing ICAM-1 expression and sICAM-1 secretion.	Iron	15-19	nuclear factor kappa B subunit 1	Homo sapiens	72-81
25306858-9	2015	Moreover, the translational control of HIF2alpha mRNA in kidney by IRP1 coordinates erythropoietin synthesis with iron and oxygen supply.	Iron	114-118	erythropoietin	Homo sapiens	84-98
25398638-8	2015	Increasing iron concentrations and incubation periods resulted in increased IL8 release.	Iron	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
25398638-10	2015	Intracellular iron sequestration was induced by IL1beta and iron and alleviated by beta-carotene.	Iron	14-18	interleukin 1 beta	Homo sapiens	48-55
25525212-5	2015	Serum iron levels were reduced in all groups at HA2.	Iron	6-10	keratin 32	Homo sapiens	48-51
25467637-8	2015	These data suggest that decreased Ndfip1 expression might contribute to the pathogenesis of 6-OHDA-induced iron accumulation and Ndfip1 could attenuate 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.	Iron	107-111	Nedd4 family interacting protein 1	Rattus norvegicus	34-40
25528477-1	2015	Transferrin, the major iron transport protein in the blood, also transports trivalent chromium in vivo.	Iron	23-27	transferrin	Homo sapiens	0-11
25455753-2	2015	Heme oxygenase (HO)-1 cleaves heme to form biliverdin, carbon monoxide (CO) and iron (Fe(2+)).	Iron	80-84	heme oxygenase 1	Mus musculus	0-21
25467637-0	2015	Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.	Iron	33-37	Nedd4 family interacting protein 1	Rattus norvegicus	0-6
25467637-5	2015	In addition, we demonstrated that overexpression of Ndfip1 caused DMT1 + IRE downregulation, resulting in the decreased iron influx and iron-induced neurotoxicity.	Iron	120-124	Nedd4 family interacting protein 1	Rattus norvegicus	52-58
25467637-5	2015	In addition, we demonstrated that overexpression of Ndfip1 caused DMT1 + IRE downregulation, resulting in the decreased iron influx and iron-induced neurotoxicity.	Iron	136-140	Nedd4 family interacting protein 1	Rattus norvegicus	52-58
25467637-8	2015	These data suggest that decreased Ndfip1 expression might contribute to the pathogenesis of 6-OHDA-induced iron accumulation and Ndfip1 could attenuate 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.	Iron	167-171	Nedd4 family interacting protein 1	Rattus norvegicus	129-135
25467637-6	2015	Although Ndfip1 knockdown led to decreased protein levels of DMT1 + IRE, partially aggravated iron-induced neurotoxicity.	Iron	94-98	Nedd4 family interacting protein 1	Rattus norvegicus	9-15
24607247-11	2015	hs-CRP was negatively correlated to serum Fe levels (r = -0 319, P &lt; 0 001).	Iron	42-44	C-reactive protein	Homo sapiens	3-6
24607247-15	2015	The negative relationship between hs-CRP and serum Fe indicated that lower serum Fe levels were related to the inflammation linked with higher BMI.	Iron	51-53	C-reactive protein	Homo sapiens	37-40
24607247-15	2015	The negative relationship between hs-CRP and serum Fe indicated that lower serum Fe levels were related to the inflammation linked with higher BMI.	Iron	81-83	C-reactive protein	Homo sapiens	37-40
25301748-8	2015	Furthermore, our findings suggest that the increased nigral iron content exacerbates the oxidative stress levels, promoting apoptosis through the Bcl-2/Bax pathway and the activated caspase-3 pathway in the brain.	Iron	60-64	B cell leukemia/lymphoma 2	Mus musculus	146-151
25765800-0	2015	[Two novel potential markers for iron metabolism: hepcidin and non-transferrin-bound iron (NTBI)].	Iron	85-89	transferrin	Homo sapiens	67-78
25765800-9	2015	In this review, the iron regulatory peptide-hormone hepcidin and non-transferrin-bound iron (NTBI) are introduced as novel potential biomarkers for iron metabolism.	Iron	87-91	transferrin	Homo sapiens	69-80
25600948-5	2015	Because iron overload in adipocytes increases systemic insulin resistance, iron handling by AT macrophages may have relevance not only to adipocyte iron stores but also to local and systemic insulin sensitivity.	Iron	8-12	insulin	Homo sapiens	55-62
25600948-5	2015	Because iron overload in adipocytes increases systemic insulin resistance, iron handling by AT macrophages may have relevance not only to adipocyte iron stores but also to local and systemic insulin sensitivity.	Iron	75-79	insulin	Homo sapiens	191-198
25529443-0	2015	Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage.	Iron	53-57	mitochondrial calcium uniporter	Homo sapiens	12-43
25529443-3	2015	This study was undertaken to identify whether blockage of MCU could ameliorate iron accumulation-associated brain injury following SAH.	Iron	79-83	mitochondrial calcium uniporter	Homo sapiens	58-61
25529443-8	2015	Interestingly, blockage of MCU dramatically reduced the iron accumulation in this area.	Iron	56-60	mitochondrial calcium uniporter	Homo sapiens	27-30
25529443-12	2015	Taken together, our results indicated that blockage of MCU could alleviate iron accumulation and the associated injury following SAH.	Iron	75-79	mitochondrial calcium uniporter	Homo sapiens	55-58
25595381-0	2015	Effects of an 11-nm DMSA-coated iron nanoparticle on the gene expression profile of two human cell lines, THP-1 and HepG2.	Iron	32-36	GLI family zinc finger 2	Homo sapiens	106-111
25378535-4	2015	Subsequent gene set enrichment analysis showed that many genes associated with the high iron cluster were involved in the toll-like receptor system (TLR4, TLR7, and TLR8) and inflammasome complex pathway (NLRP3, NLRC4, and CASP1).	Iron	88-92	toll like receptor 7	Homo sapiens	155-159
25378535-4	2015	Subsequent gene set enrichment analysis showed that many genes associated with the high iron cluster were involved in the toll-like receptor system (TLR4, TLR7, and TLR8) and inflammasome complex pathway (NLRP3, NLRC4, and CASP1).	Iron	88-92	toll like receptor 8	Homo sapiens	165-169
25378535-4	2015	Subsequent gene set enrichment analysis showed that many genes associated with the high iron cluster were involved in the toll-like receptor system (TLR4, TLR7, and TLR8) and inflammasome complex pathway (NLRP3, NLRC4, and CASP1).	Iron	88-92	NLR family pyrin domain containing 3	Homo sapiens	205-210
25378535-4	2015	Subsequent gene set enrichment analysis showed that many genes associated with the high iron cluster were involved in the toll-like receptor system (TLR4, TLR7, and TLR8) and inflammasome complex pathway (NLRP3, NLRC4, and CASP1).	Iron	88-92	NLR family CARD domain containing 4	Homo sapiens	212-217
25378535-4	2015	Subsequent gene set enrichment analysis showed that many genes associated with the high iron cluster were involved in the toll-like receptor system (TLR4, TLR7, and TLR8) and inflammasome complex pathway (NLRP3, NLRC4, and CASP1).	Iron	88-92	caspase 1	Homo sapiens	223-228
25378535-6	2015	Further linking intracellular iron and inflammation, 14 SCD patients with a ferroportin Q248H variant that causes intracellular iron accumulation had significantly higher levels of interleukin-6 and C-reactive protein compared with 14 matched SCD patients with the wild-type allele (P&lt;0.05).	Iron	128-132	interleukin 6	Homo sapiens	181-194
25378535-6	2015	Further linking intracellular iron and inflammation, 14 SCD patients with a ferroportin Q248H variant that causes intracellular iron accumulation had significantly higher levels of interleukin-6 and C-reactive protein compared with 14 matched SCD patients with the wild-type allele (P&lt;0.05).	Iron	128-132	C-reactive protein	Homo sapiens	199-217
25597503-2	2015	In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the formation of a persulfide intermediate on NFS1.	Iron	33-37	LYR motif containing 4	Homo sapiens	81-86
25597503-2	2015	In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the formation of a persulfide intermediate on NFS1.	Iron	33-37	iron-sulfur cluster assembly enzyme	Homo sapiens	87-91
25595381-12	2015	Id3 can be used as a nanotoxicity biomarker for iron nanoparticles.	Iron	48-52	inhibitor of DNA binding 3, HLH protein	Homo sapiens	0-3
25378496-13	2015	PK1 interacts with both ferritin and apoferritin, suppresses apoferritin"s ability to sequester free iron ions, and maintains the intracellular labile iron pool (LIP), and thus the availability of free iron is increased within cells.	Iron	101-105	pyruvate kinase L/R	Homo sapiens	0-3
25759633-4	2015	Expert societies recommend screening of asymptomatic and symptomatic individuals with hemochromatosis by obtaining transferrin saturation (calculated as serum iron/total iron binding capacity x 100).	Iron	159-163	transferrin	Homo sapiens	115-126
25759633-4	2015	Expert societies recommend screening of asymptomatic and symptomatic individuals with hemochromatosis by obtaining transferrin saturation (calculated as serum iron/total iron binding capacity x 100).	Iron	170-174	transferrin	Homo sapiens	115-126
25759633-7	2015	In patients with features of iron overload and high serum ferritin levels, low or normal transferrin saturation should alert the physician to other - primary as well as secondary - causes of iron overload besides hemochromatosis.	Iron	191-195	transferrin	Homo sapiens	89-100
25378496-0	2015	White spot syndrome virus protein kinase 1 defeats the host cell"s iron-withholding defense mechanism by interacting with host ferritin.	Iron	67-71	pyruvate kinase L/R	Homo sapiens	26-42
25378496-7	2015	When PK1 was overexpressed in Sf9 cells, the cellular labile iron pool (LIP) levels were elevated significantly.	Iron	61-65	pyruvate kinase L/R	Homo sapiens	5-8
25378496-9	2015	Taken together, these results suggest that PK1 prevents apoferritin from iron loading, and thus stabilizes the cellular LIP levels, and that WSSV uses this novel mechanism to counteract the host cell"s iron-withholding defense mechanism.	Iron	73-77	pyruvate kinase L/R	Homo sapiens	43-46
25378496-13	2015	PK1 interacts with both ferritin and apoferritin, suppresses apoferritin"s ability to sequester free iron ions, and maintains the intracellular labile iron pool (LIP), and thus the availability of free iron is increased within cells.	Iron	151-155	pyruvate kinase L/R	Homo sapiens	0-3
25378496-13	2015	PK1 interacts with both ferritin and apoferritin, suppresses apoferritin"s ability to sequester free iron ions, and maintains the intracellular labile iron pool (LIP), and thus the availability of free iron is increased within cells.	Iron	151-155	pyruvate kinase L/R	Homo sapiens	0-3
25535360-6	2015	To improve HIF-1alpha activity we designed a transdermal drug delivery system (TDDS) containing the FDA-approved small molecule deferoxamine (DFO), an iron chelator that increases HIF-1alpha transactivation in diabetes by preventing iron-catalyzed reactive oxygen stress.	Iron	151-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-190
25277871-3	2015	RESULTS: As the genotypic risk for iron overload increased, transferrin saturation and serum NTBI levels increased while serum hepcidin levels decreased.	Iron	35-39	transferrin	Homo sapiens	60-71
25476866-1	2015	Fibrils formed by human serum transferrin [(1-3 muM) apo-Tf, partially iron-saturated (Fe0.6 -Tf) and holo-Tf (Fe2 -Tf) forms], from dilute bicarbonate solutions, were deposited on formvar surfaces and studied by electron microscopy.	Iron	71-75	transferrin	Homo sapiens	30-41
25348606-9	2015	In our model, we propose that NO produced upon TCDD exposure interacts with the iron centers of iron-regulatory proteins (IRPs) that modulate the alteration of ferritin and transferrin, resulting in an augmented cellular LIP and, hence, increased toxicity.	Iron	80-84	transferrin	Homo sapiens	173-184
26566051-6	2015	Intracellular iron chelation attenuates TNF and cycloheximide (CHX)-induced LMP and cell death, demonstrating the critical role of this transition metal in mediating cytokine lethality.	Iron	14-18	tumor necrosis factor	Rattus norvegicus	40-43
26566051-9	2015	These results provide evidence that intralysosomal iron-catalyzed redox reactions play a key role in TNF and CHX-induced LMP and toxicity.	Iron	51-55	tumor necrosis factor	Rattus norvegicus	101-104
26566051-10	2015	The finding that chelation of intralysosomal iron achieved by autophagic delivery of MT, and to some degree probably of other iron-binding proteins as well, into the lysosomal compartment is highly protective provides a putative mechanism to explain autophagy-related suppression of death by TNF and CHX.	Iron	45-49	tumor necrosis factor	Rattus norvegicus	292-295
26788496-5	2015	The significantly increased FPN1 level in small intestine facilitates digestive iron absorption, which maintains the serum iron concentration at a near-normal level to meet the increase of iron requirements.	Iron	80-84	solute carrier family 40 member 1	Rattus norvegicus	28-32
26649297-1	2015	Soluble lactoferrin (LTF) is a versatile molecule that not only regulates the iron homeostasis, but also harbors direct microbicidal and immunomodulating abilities in mammalian body fluids.	Iron	78-82	lactotransferrin	Homo sapiens	8-19
26649297-1	2015	Soluble lactoferrin (LTF) is a versatile molecule that not only regulates the iron homeostasis, but also harbors direct microbicidal and immunomodulating abilities in mammalian body fluids.	Iron	78-82	lactotransferrin	Homo sapiens	21-24
26788496-5	2015	The significantly increased FPN1 level in small intestine facilitates digestive iron absorption, which maintains the serum iron concentration at a near-normal level to meet the increase of iron requirements.	Iron	123-127	solute carrier family 40 member 1	Rattus norvegicus	28-32
26788496-5	2015	The significantly increased FPN1 level in small intestine facilitates digestive iron absorption, which maintains the serum iron concentration at a near-normal level to meet the increase of iron requirements.	Iron	123-127	solute carrier family 40 member 1	Rattus norvegicus	28-32
26788496-6	2015	Moreover, a significant decrease of hepcidin expression is observed during late-pregnancy and early-lactation stages, suggesting the important regulatory role that hepcidin plays in iron metabolism during pregnancy and lactation.	Iron	182-186	hepcidin antimicrobial peptide	Rattus norvegicus	36-44
26788496-6	2015	Moreover, a significant decrease of hepcidin expression is observed during late-pregnancy and early-lactation stages, suggesting the important regulatory role that hepcidin plays in iron metabolism during pregnancy and lactation.	Iron	182-186	hepcidin antimicrobial peptide	Rattus norvegicus	164-172
26788496-7	2015	These results are fundamental to the understanding of iron homeostasis during pregnancy and lactation and may provide experimental bases for future studies to identify key molecules expressed during these special periods that regulate the expression of hepcidin, to eventually improve the iron-deficiency status.	Iron	54-58	hepcidin antimicrobial peptide	Rattus norvegicus	253-261
26211665-1	2015	Haptoglobin (Hp) is an acute-phase protein that is produced by the liver to capture the iron that is present in the blood circulation, thus avoiding its accumulation in the blood.	Iron	88-92	haptoglobin	Homo sapiens	0-11
26521945-7	2015	In this regard, plasma transferrin, which is an iron mediator related to eicosanoid signaling, may be related to social impairment of ASD.	Iron	48-52	transferrin	Homo sapiens	23-34
26090431-4	2015	The latest regulates Fe concentration through several iron-containing proteins, such as transferrin.	Iron	21-23	transferrin	Homo sapiens	88-99
26090431-4	2015	The latest regulates Fe concentration through several iron-containing proteins, such as transferrin.	Iron	54-58	transferrin	Homo sapiens	88-99
26090431-5	2015	The transferrin receptor transports iron to each cell that needs it and maintains it away from pathogens.	Iron	36-40	transferrin	Homo sapiens	4-15
26090431-6	2015	Parasites have developed several strategies to obtain iron as the expression of specific transferrin receptors localized on plasma membrane, internalized through endocytosis.	Iron	54-58	transferrin	Homo sapiens	89-100
26295816-0	2015	Chronic Migraineurs Form Carboxyhemefibrinogen and Iron-Bound Fibrinogen.	Iron	51-55	fibrinogen beta chain	Homo sapiens	62-72
26295816-3	2015	Further, CO and iron enhance plasmatic coagulation in part via a fibrinogen-dependent mechanism.	Iron	16-20	fibrinogen beta chain	Homo sapiens	65-75
26023012-5	2015	(2) TNF-alpha accelerated iron accumulation and oxidative stress in human umbilical vein endothelial cells in a manner similar to that in MHD-PMNLs.	Iron	26-30	tumor necrosis factor	Homo sapiens	4-13
26023012-8	2015	(5) The index of arterial stiffness was aggravated in MHD patients and was associated with serum hepcidin and TNF-alpha levels, which could inhibit iron exit from cells.	Iron	148-152	tumor necrosis factor	Homo sapiens	110-119
26023017-4	2015	Maintaining adequate iron stores is clearly accepted as the most important strategy for reducing the ESA requirement and for enhancing ESA efficacy.	Iron	21-25	paraoxonase 1	Homo sapiens	101-104
26023017-4	2015	Maintaining adequate iron stores is clearly accepted as the most important strategy for reducing the ESA requirement and for enhancing ESA efficacy.	Iron	21-25	paraoxonase 1	Homo sapiens	135-138
25732555-5	2015	In several pathological conditions in which free heme-Fe levels increase, the buffering capacity of plasma hemopexin is overwhelmed and most of heme-Fe binds to the fatty acid site 1 of HSA.	Iron	54-56	albumin	Homo sapiens	186-189
25732555-7	2015	Remarkably, heme-Fe-mediated HSA properties are time-dependent, representing a case for "chronosteric effects".	Iron	17-19	albumin	Homo sapiens	29-32
25732555-8	2015	Here, we review the drug-based modulation of (i) heme-Fe-recognition by HSA and (ii) heme-Fe-mediated reactivity.	Iron	54-56	albumin	Homo sapiens	72-75
25416640-1	2015	Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations.	Iron	72-76	transmembrane serine protease 6	Homo sapiens	0-32
25413109-10	2015	The results showed that Fe-enriched peat was most effective in immobilizing As(V).	Iron	24-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	76-81
26106435-8	2015	Histological examination of the liver section revealed reduced inflammatory cells infiltration, collagen, and iron deposition in CCl4 treated rats.	Iron	110-114	C-C motif chemokine ligand 4	Rattus norvegicus	129-133
26470653-1	2015	Transferrin (Tf) is a glycosylated protein responsible for transporting iron.	Iron	72-76	transferrin	Homo sapiens	0-11
26118715-1	2015	Dysregulation of iron homeostasis is a potential risk factor for type 2 diabetes mellitus (T2DM) and insulin resistance.	Iron	17-21	insulin	Homo sapiens	101-108
26118715-10	2015	These findings suggest that dysregulation of mitochondrial iron metabolism elicited by knockdown of Mfrn1/2 results in mitochondrial dysfunction, which culminates in the compromise of differentiation and insulin insensitivity of adipocytes.	Iron	59-63	insulin	Homo sapiens	204-211
25416640-0	2015	Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses.	Iron	120-124	transmembrane serine protease 6	Homo sapiens	56-88
25416640-1	2015	Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations.	Iron	72-76	transmembrane serine protease 6	Homo sapiens	34-41
25416640-0	2015	Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses.	Iron	120-124	transmembrane serine protease 6	Homo sapiens	90-97
25416640-2	2015	Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status.	Iron	126-130	transmembrane serine protease 6	Homo sapiens	81-88
25416640-3	2015	To get a more precise evaluation of identified TMPRSS6 single nucleotide polymorphism associations with iron status in cohorts of differing continental ancestry, we conducted a systematic review with meta-analyses.	Iron	104-108	transmembrane serine protease 6	Homo sapiens	47-54
26779261-4	2015	Experimental studies suggest that anabolic hormones such as testosterone, IGF-1, and thyroid hormones are able to increase erythroid mass, erythropoietin synthesis, and iron bioavailability, underlining a potential role of multiple hormonal changes in the anemia of aging.	Iron	169-173	insulin like growth factor 1	Homo sapiens	74-79
26637695-3	2015	Functional iron deficiency, mediated principally by the interaction of interleukin-6, the iron regulatory hormone hepcidin, and the iron exporter ferroportin, is a major contributor to the anemia of chronic disease.	Iron	11-15	interleukin 6	Homo sapiens	71-84
25572183-1	2015	Iron overload is a common finding in chronically transfused beta-thalassemia major (beta-TM) patients with possible effect on beta cell function and insulin resistance.	Iron	0-4	insulin	Homo sapiens	149-156
26029793-3	2015	Although non-transferrin-bound iron (NTBI) is a reliable indicator for iron overload, it is still not universally available.	Iron	31-35	transferrin	Homo sapiens	13-24
26029793-3	2015	Although non-transferrin-bound iron (NTBI) is a reliable indicator for iron overload, it is still not universally available.	Iron	71-75	transferrin	Homo sapiens	13-24
26029793-9	2015	Non-transferrin-bound iron was weakly correlated to all time-domain HRV parameters.	Iron	22-26	transferrin	Homo sapiens	4-15
25300398-7	2015	In Bmp6-/- mice, iron challenge led to blunted activation of liver Smad signaling and hepcidin expression with a delay of 24 h, associated with increased Bmp5 and Bmp7 expression and increased Bmp2, 4, 5 and 9 expression in the duodenum.	Iron	17-21	bone morphogenetic protein 2	Mus musculus	193-200
24757071-0	2015	Partially degradable friction-welded pure iron-stainless steel 316L bone pin.	Iron	42-46	dynein light chain LC8-type 1	Homo sapiens	73-76
25114080-5	2015	Through one pathway, HO-1 promotes the expression of CDK5 by accumulating reactive oxygen species, which are produced by HO-1 downstream products of iron in neuro2a cell lines and mouse brain.	Iron	149-153	heme oxygenase 1	Mus musculus	21-25
25114080-5	2015	Through one pathway, HO-1 promotes the expression of CDK5 by accumulating reactive oxygen species, which are produced by HO-1 downstream products of iron in neuro2a cell lines and mouse brain.	Iron	149-153	heme oxygenase 1	Mus musculus	121-125
25273340-0	2015	Comparative study of the interaction of meso-tetrakis (N-para-trimethyl-anilium) porphyrin (TMAP) in its free base and Fe derivative form with oligo(dA.dT)15 and oligo(dG.dC)15.	Iron	119-121	cytoskeleton associated protein 2	Homo sapiens	92-96
24757071-7	2015	The corrosion rate of the pin gradually decreased from the undeformed zone of pure iron to the undeformed zone of stainless steel 316L.	Iron	83-87	dynein light chain LC8-type 1	Homo sapiens	26-29
25435028-0	2015	Non transferrin bound iron (NTBI) in acute leukemias throughout conventional intensive chemotherapy: kinetics of its appearance and potential predictive role in infectious complications.	Iron	22-26	transferrin	Homo sapiens	4-15
25315861-4	2015	The existing paradigm assumes that the endothelial cells (ECs) forming the blood-brain barrier (BBB) serve as a simple conduit for transport of transferrin-bound iron.	Iron	162-166	transferrin	Homo sapiens	144-155
25315861-6	2015	Using an in vivo model of brain iron deficiency, the Belgrade rat, we show the distribution of transferrin receptors in brain microvasculature is altered in luminal, intracellular, and abluminal membranes dependent on brain iron status.	Iron	32-36	transferrin	Homo sapiens	95-106
25315861-7	2015	We used a cell culture model of the BBB to show the presence of factors that influence iron release in non-human primate cerebrospinal fluid and conditioned media from astrocytes; specifically apo-transferrin and hepcidin were found to increase and decrease iron release, respectively.	Iron	87-91	transferrin	Homo sapiens	197-208
26328315-1	2015	To investigate the possibility of drug targeting via the transferrin receptor-mediated pathway, iron-saturated transferrin was conjugated with chitosan (Tr-chitosan) and complexed with doxorubicin-conjugated methoxy poly(ethylene glycol)-b-dextran succinate (DEX-DOX).	Iron	96-100	transferrin	Homo sapiens	57-68
26328315-1	2015	To investigate the possibility of drug targeting via the transferrin receptor-mediated pathway, iron-saturated transferrin was conjugated with chitosan (Tr-chitosan) and complexed with doxorubicin-conjugated methoxy poly(ethylene glycol)-b-dextran succinate (DEX-DOX).	Iron	96-100	transferrin	Homo sapiens	111-122
26160488-8	2015	Functional iron deficiency was associated with significantly higher serum levels of fibrinogen, ferritin, transferrin saturation, total iron binding capacity, hepcidin and older age relative to patients with absolute iron deficiency.	Iron	11-15	fibrinogen beta chain	Homo sapiens	84-94
26160488-8	2015	Functional iron deficiency was associated with significantly higher serum levels of fibrinogen, ferritin, transferrin saturation, total iron binding capacity, hepcidin and older age relative to patients with absolute iron deficiency.	Iron	11-15	transferrin	Homo sapiens	106-117
25435028-1	2015	We analyzed appearance of non transferrin bound iron (NTBI) in 30 transplant eligible patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) during conventional chemotherapy treatment program and evaluated possible relationship with transfusional body iron intake, iron parameters and clinical complications.	Iron	48-52	transferrin	Homo sapiens	30-41
25567982-4	2015	Here we found that expression of Bcl2 results in decreased HR activity and retards the repair of DSBs induced by HZE particles (i.e. (56)iron and (28)silicon) by inhibiting Mre11 complex activity.	Iron	137-141	BCL2 apoptosis regulator	Homo sapiens	33-37
25561562-0	2015	Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.	Iron	173-177	signal transducer and activator of transcription 3	Homo sapiens	38-88
25561562-0	2015	Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.	Iron	173-177	signal transducer and activator of transcription 3	Homo sapiens	90-95
25561562-0	2015	Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.	Iron	173-177	interleukin 6	Homo sapiens	137-150
25561562-9	2015	Collectively, these studies demonstrate suppression of STAT3 activity by iron depletion in vitro and in vivo, and reveal insights into regulation of the critical oncogenic STAT3 pathway.	Iron	73-77	signal transducer and activator of transcription 3	Homo sapiens	55-60
25567982-5	2015	Exposure of cells to (56)iron or (28)silicon promotes Bcl2 to interact with Mre11 via the BH1 and BH4 domains.	Iron	25-29	BCL2 apoptosis regulator	Homo sapiens	54-58
25567982-5	2015	Exposure of cells to (56)iron or (28)silicon promotes Bcl2 to interact with Mre11 via the BH1 and BH4 domains.	Iron	25-29	MRE11 homolog, double strand break repair nuclease	Homo sapiens	76-81
25896138-1	2015	Neurodegeneration with brain iron accumulation type 1 (NBIA-1) is a rare disorder characterized by progressive extrapyramidal dysfunction and dementia.	Iron	29-33	pantothenate kinase 2	Homo sapiens	55-61
25896138-2	2015	NBIA-1 encompasses typical iron brain accumulation, mostly in the globus pallidus with secondary dementia, spasticity, rigidity, dystonia, and choreoathetosis.	Iron	27-31	pantothenate kinase 2	Homo sapiens	0-6
25587028-2	2014	Concurrent attenuation of oxidative phosphorylation and HIF-1alpha/PKM2-dependent glycolysis promotes a non-apoptotic, iron- and oxygen-dependent cell death that we term ferroxitosis.	Iron	119-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
25556867-8	2015	After a mean +- SD follow-up of 13.1 +- 5.6 days, intravenous iron increased hemoglobin level by 1.2 g/dl (95% confidence interval [CI] 0.45-1.9, p=0.005), ferritin level by 364.2 ng/ml (95% CI 129.7-598.7, p=0.007), and transferrin saturation by 10.5% (95% CI 6.5-14.6%, p&lt;0.001).	Iron	62-66	transferrin	Homo sapiens	221-232
25832833-8	2015	A portion of the iron from ferric citrate hydrate is absorbed and transported throughout the body as transferrin-bound iron, where it is used for the synthesis of hemoglobin, enzymes, and others.	Iron	17-21	transferrin	Homo sapiens	101-112
25832833-8	2015	A portion of the iron from ferric citrate hydrate is absorbed and transported throughout the body as transferrin-bound iron, where it is used for the synthesis of hemoglobin, enzymes, and others.	Iron	119-123	transferrin	Homo sapiens	101-112
25523922-4	2014	Moreover, CUR-induced Hog1 phosphorylation was rescued by supplementation of iron to the growth medium.	Iron	77-81	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	22-26
25516512-2	2014	The mechanism involves not only hepcidin, the key hormone in iron metabolism, but also iron-related proteins and signaling-transduction molecules, such as IL-6 and signal transducer and activator of transcription 3 (Stat3).	Iron	61-65	hepcidin antimicrobial peptide	Rattus norvegicus	32-40
25516512-2	2014	The mechanism involves not only hepcidin, the key hormone in iron metabolism, but also iron-related proteins and signaling-transduction molecules, such as IL-6 and signal transducer and activator of transcription 3 (Stat3).	Iron	87-91	interleukin 6	Rattus norvegicus	155-159
25548482-18	2014	CONCLUSION: This study provides evidence that p62/IGF2BP2-2 drives the progression of NASH through elevation of hepatic iron deposition and increased production of hepatic free cholesterol.	Iron	120-124	insulin-like growth factor 2 mRNA binding protein 2	Mus musculus	50-57
25624847-3	2014	Overt labile plasma iron (LPI) represents a component of non-transferrin bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	20-24	transferrin	Homo sapiens	61-72
25624847-3	2014	Overt labile plasma iron (LPI) represents a component of non-transferrin bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	79-83	transferrin	Homo sapiens	61-72
25624847-3	2014	Overt labile plasma iron (LPI) represents a component of non-transferrin bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	79-83	transferrin	Homo sapiens	61-72
25525375-13	2014	Also, the annual total amount of intravenous iron supplementation during the DA/EPO period was significantly reduced compared with that during the EPO period (546+-304 mg/year vs 684+-314 mg/year, P&lt;0.05).	Iron	45-49	erythropoietin	Homo sapiens	77-83
25503569-5	2014	This finding may permit the development of an advanced energy-efficient and clean fuel-oriented FTS process on the basis of a cost-effective iron catalyst.	Iron	141-145	AKT interacting protein	Homo sapiens	96-99
25504720-0	2014	Escape from bacterial iron piracy through rapid evolution of transferrin.	Iron	22-26	transferrin	Homo sapiens	61-72
25504720-3	2014	We show that the iron transport protein transferrin is engaged in ancient and ongoing evolutionary conflicts with TbpA, a transferrin surface receptor from bacteria.	Iron	17-21	transferrin	Homo sapiens	40-51
25504720-3	2014	We show that the iron transport protein transferrin is engaged in ancient and ongoing evolutionary conflicts with TbpA, a transferrin surface receptor from bacteria.	Iron	17-21	transferrin	Homo sapiens	122-133
25504720-4	2014	Single substitutions in transferrin at rapidly evolving sites reverse TbpA binding, providing a mechanism to counteract bacterial iron piracy among great apes.	Iron	130-134	transferrin	Homo sapiens	24-35
25763255-3	2015	Recently, recombinant human erythropoietin (rhEPO) has been used to treat the patients already taking iron supplements.	Iron	102-106	erythropoietin	Homo sapiens	28-42
25525375-13	2014	Also, the annual total amount of intravenous iron supplementation during the DA/EPO period was significantly reduced compared with that during the EPO period (546+-304 mg/year vs 684+-314 mg/year, P&lt;0.05).	Iron	45-49	erythropoietin	Homo sapiens	80-83
25696857-3	2014	Before chelation therapy, transfusional volume is an accurate method for estimating liver iron burden, whereas transferrin saturation reflects the risk of extrahepatic iron deposition.	Iron	168-172	transferrin	Homo sapiens	111-122
25364507-3	2014	Iron(III) in the nanoshells can interact with endogenous transferrin, a serum protein found in mammalian cell culture media, which subsequently promotes transport of the nanoshells into cells by the transferrin receptor-mediated endocytosis pathway.	Iron	0-4	transferrin	Homo sapiens	57-68
25364507-3	2014	Iron(III) in the nanoshells can interact with endogenous transferrin, a serum protein found in mammalian cell culture media, which subsequently promotes transport of the nanoshells into cells by the transferrin receptor-mediated endocytosis pathway.	Iron	0-4	transferrin	Homo sapiens	199-210
25346449-7	2014	Bulk and microfocused As K-edge X-ray absorption near-edge structure spectroscopy confirmed that As(V) was reduced to As(III) and showed that in the presence of FeS, solid-phase As was retained partly via the formation of an As2S3-like species.	Iron	161-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	97-102
25152357-1	2014	BACKGROUND: Iron oxidation is thought to be predominantly handled enzymatically in the body, to minimize spontaneous combustion with oxygen and to facilitate cellular iron export by loading transferrin.	Iron	12-16	transferrin	Homo sapiens	190-201
25464026-0	2014	beta-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin.	Iron	113-117	amyloid beta precursor protein	Homo sapiens	0-30
25464026-2	2014	We recently reported that the amyloid precursor protein (APP) is the analogous iron-exporting chaperone for neurons and other cells.	Iron	79-83	amyloid beta precursor protein	Homo sapiens	30-55
25224009-2	2014	VT-1161 produced a type II binding spectrum with Candida albicans CYP51, characteristic of heme iron coordination.	Iron	96-100	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	66-71
25152357-1	2014	BACKGROUND: Iron oxidation is thought to be predominantly handled enzymatically in the body, to minimize spontaneous combustion with oxygen and to facilitate cellular iron export by loading transferrin.	Iron	167-171	transferrin	Homo sapiens	190-201
25283820-5	2014	Transferrin receptor and L-ferritin expression, both indicators of iron status, were altered in double transgenic and SOD1 mice starting at 90days, indicating loss of iron homeostasis in these mice.	Iron	67-71	superoxide dismutase 1, soluble	Mus musculus	118-122
25239763-0	2014	Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons.	Iron	98-102	glial cell derived neurotrophic factor	Homo sapiens	38-81
25239763-2	2014	However, it is unknown whether neurotrophic factors, brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) participate in the modulation of neuronal iron metabolism.	Iron	191-195	glial cell derived neurotrophic factor	Homo sapiens	143-147
25239763-3	2014	Here, we investigated the effects and underlying mechanisms of BDNF and GDNF on the iron influx process in primary cultured ventral mesencephalic neurons.	Iron	84-88	glial cell derived neurotrophic factor	Homo sapiens	72-76
25239763-4	2014	6-hydroxydopamine-induced enhanced ferrous iron influx via improper up-regulation of divalent metal transporter 1 with iron responsive element (DMT1+IRE) was consistently relieved by BDNF and GDNF.	Iron	43-47	glial cell derived neurotrophic factor	Homo sapiens	192-196
25239763-4	2014	6-hydroxydopamine-induced enhanced ferrous iron influx via improper up-regulation of divalent metal transporter 1 with iron responsive element (DMT1+IRE) was consistently relieved by BDNF and GDNF.	Iron	119-123	glial cell derived neurotrophic factor	Homo sapiens	192-196
25239763-9	2014	Taken together, these results show that BDNF and GDNF ameliorate iron accumulation via the ERK/Akt pathway, followed by inhibition of IRP1 and DMT1+IRE expression, which may provide new targets for the neuroprotective effects of these neurotrophic factors.	Iron	65-69	glial cell derived neurotrophic factor	Homo sapiens	49-53
25239763-9	2014	Taken together, these results show that BDNF and GDNF ameliorate iron accumulation via the ERK/Akt pathway, followed by inhibition of IRP1 and DMT1+IRE expression, which may provide new targets for the neuroprotective effects of these neurotrophic factors.	Iron	65-69	mitogen-activated protein kinase 1	Homo sapiens	91-94
25399609-0	2014	Protein moonlighting in iron metabolism: glyceraldehyde-3-phosphate dehydrogenase (GAPDH).	Iron	24-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	41-81
25239763-9	2014	Taken together, these results show that BDNF and GDNF ameliorate iron accumulation via the ERK/Akt pathway, followed by inhibition of IRP1 and DMT1+IRE expression, which may provide new targets for the neuroprotective effects of these neurotrophic factors.	Iron	65-69	AKT serine/threonine kinase 1	Homo sapiens	95-98
25399609-0	2014	Protein moonlighting in iron metabolism: glyceraldehyde-3-phosphate dehydrogenase (GAPDH).	Iron	24-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	83-88
25380676-6	2014	Iron supplementation decreased liver superoxide dismutase (T-SOD) and catalase (CAT) activity (P &lt; 0.01) and increased iron concentration in the liver compared to HH group (P &lt; 0.001).	Iron	0-4	catalase	Rattus norvegicus	59-78
25280951-1	2014	Lactoferrin (Lf), present in colostrum and milk is a member of the transferrin family of iron-binding glyco-proteins, with stronger binding capacity to ferric iron than hemoglobin, myoglobin or transferrin.	Iron	89-93	serotransferrin	Bos taurus	67-78
25380676-6	2014	Iron supplementation decreased liver superoxide dismutase (T-SOD) and catalase (CAT) activity (P &lt; 0.01) and increased iron concentration in the liver compared to HH group (P &lt; 0.001).	Iron	0-4	catalase	Rattus norvegicus	80-83
25380676-10	2014	Moreover, iron supplementation at high altitudes affected HIF-1alpha-mediated regulating expression of targeting genes such as EPO and transferrin.	Iron	10-14	transferrin	Rattus norvegicus	135-146
25209728-0	2014	Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients.	Iron	43-47	transferrin	Homo sapiens	25-36
24991945-3	2014	A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen.	Iron	39-43	fibrinogen beta chain	Homo sapiens	122-132
24991945-3	2014	A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen.	Iron	39-43	fibrinogen beta chain	Homo sapiens	186-196
24991945-3	2014	A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen.	Iron	143-147	fibrinogen beta chain	Homo sapiens	186-196
24991945-6	2014	Thus, reversible iron binding to fibrinogen mechanistically explains a significant portion of coagulation kinetic and ultrastructural hypercoagulability.	Iron	17-21	fibrinogen beta chain	Homo sapiens	33-43
25209728-2	2014	Relative mechanisms of plasma non-transferrin bound iron (NTBI) generation may account for these differences.	Iron	52-56	transferrin	Homo sapiens	34-45
24889867-5	2014	Under these conditions, Cathepsin L was also proved to interact with cystatin B, being also modulated by physiological concentrations of Cu(++) , Fe(++) and Zn(++) .	Iron	146-152	cathepsin L	Homo sapiens	24-35
25100226-6	2014	Due to the chemical oxidant of NO2 (-) and the NO3 (-) dependent ferrous iron oxidation by anammox bacteria, the iron-reducing activity of anammox bacteria could be severely inhibited when iron-reducing pathway and the anammox process were coupled.	Iron	73-77	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
25100226-6	2014	Due to the chemical oxidant of NO2 (-) and the NO3 (-) dependent ferrous iron oxidation by anammox bacteria, the iron-reducing activity of anammox bacteria could be severely inhibited when iron-reducing pathway and the anammox process were coupled.	Iron	113-117	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
25100226-6	2014	Due to the chemical oxidant of NO2 (-) and the NO3 (-) dependent ferrous iron oxidation by anammox bacteria, the iron-reducing activity of anammox bacteria could be severely inhibited when iron-reducing pathway and the anammox process were coupled.	Iron	113-117	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
25456519-2	2014	Iron can upregulate the production of amyloid precursor protein (APP).	Iron	0-4	amyloid beta precursor protein	Homo sapiens	38-63
24889867-5	2014	Under these conditions, Cathepsin L was also proved to interact with cystatin B, being also modulated by physiological concentrations of Cu(++) , Fe(++) and Zn(++) .	Iron	146-152	cystatin B	Homo sapiens	69-79
25111043-1	2014	Heme oxygenase-1 (HO-1) encoded by the HMOX1 gene is a 32-kDa stress protein that catabolizes heme to biliverdin, free iron, and carbon monoxide (CO).	Iron	119-123	heme oxygenase 1	Mus musculus	0-16
25111043-1	2014	Heme oxygenase-1 (HO-1) encoded by the HMOX1 gene is a 32-kDa stress protein that catabolizes heme to biliverdin, free iron, and carbon monoxide (CO).	Iron	119-123	heme oxygenase 1	Mus musculus	18-22
25111043-1	2014	Heme oxygenase-1 (HO-1) encoded by the HMOX1 gene is a 32-kDa stress protein that catabolizes heme to biliverdin, free iron, and carbon monoxide (CO).	Iron	119-123	heme oxygenase 1	Mus musculus	39-44
25224641-0	2014	Self-oxidation of cytochrome c at methionine80 with molecular oxygen induced by cleavage of the Met-heme iron bond.	Iron	105-109	cytochrome c, somatic	Homo sapiens	18-30
25404782-9	2014	The electronic properties of the bis-phosphinite PONOP and bis-phosphite PONOP iron complexes are intermediate between previously reported PNP and PDI iron complexes, with the PONOP ligands exhibiting stronger electron donating ability than PDI ligands, but promoting a less electron rich metal center than found in analogous PNP iron complexes.	Iron	79-83	purine nucleoside phosphorylase	Homo sapiens	139-142
25404782-9	2014	The electronic properties of the bis-phosphinite PONOP and bis-phosphite PONOP iron complexes are intermediate between previously reported PNP and PDI iron complexes, with the PONOP ligands exhibiting stronger electron donating ability than PDI ligands, but promoting a less electron rich metal center than found in analogous PNP iron complexes.	Iron	79-83	purine nucleoside phosphorylase	Homo sapiens	326-329
24659348-2	2014	Our previous study demonstrated that lipopolysaccharides (LPS) can regulate expression of iron-regulatory peptide hepcidin; however, the mechanism is undefined.	Iron	90-94	hepcidin antimicrobial peptide	Rattus norvegicus	114-122
25385842-9	2014	In conclusion, the findings of this study indicate that hyperinsulnemia could induce hepatic iron overload by upregulating liver TFR1 via the PI3K/AKT/mTOR/IRP2 pathway, which may be one of the main reasons for the occurrence of DIOS.	Iron	93-97	AKT serine/threonine kinase 1	Rattus norvegicus	147-150
25842584-9	2014	There was positive correlation of homeostasis model of insulin resistance with fasting blood sugar (r=0.596; p&lt;0.001), serum ferritin (r=0.306; p&lt;0.008), insulin (r=0.866; p&lt;0.001), and total iron-binding capacity (r=0.302; p&lt;0.009).	Iron	201-205	insulin	Homo sapiens	55-62
25224641-1	2014	Met80 of cytochrome c (cyt c) has been shown to dissociate from its heme iron when cyt c interacts with cardiolipin (CL), which triggers the release of cyt c into the cytosol initiating apoptosis.	Iron	73-77	cytochrome c, somatic	Homo sapiens	9-21
25224641-1	2014	Met80 of cytochrome c (cyt c) has been shown to dissociate from its heme iron when cyt c interacts with cardiolipin (CL), which triggers the release of cyt c into the cytosol initiating apoptosis.	Iron	73-77	cytochrome c, somatic	Homo sapiens	23-28
25224641-1	2014	Met80 of cytochrome c (cyt c) has been shown to dissociate from its heme iron when cyt c interacts with cardiolipin (CL), which triggers the release of cyt c into the cytosol initiating apoptosis.	Iron	73-77	cytochrome c, somatic	Homo sapiens	83-88
25224641-1	2014	Met80 of cytochrome c (cyt c) has been shown to dissociate from its heme iron when cyt c interacts with cardiolipin (CL), which triggers the release of cyt c into the cytosol initiating apoptosis.	Iron	73-77	cytochrome c, somatic	Homo sapiens	83-88
25224641-6	2014	These results indicate that Met80 of cyt c is oxidized site-specifically by formation of the oxy and subsequent compound I-like species when Met80 dissociates from the heme iron, where the Met80 modification may affect its peroxidase activity related to apoptosis.	Iron	173-177	cytochrome c, somatic	Homo sapiens	37-42
25249289-3	2014	In this study, we have shown that exogenously added iron in the form of ferric ammonium citrate (FAC) leads to considerable accumulation of amyloid precursor protein (APP) without a corresponding change in the concerned gene expression in cultured SHSY5Y cells during exposure up to 48 h. This phenomenon is also associated with increased beta-secretase activity and augmented release of amyloid beta 42 in the medium.	Iron	52-56	amyloid beta precursor protein	Homo sapiens	140-165
25606020-1	2014	Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae.	Iron	84-88	Nfu1p	Saccharomyces cerevisiae S288C	22-26
25606020-1	2014	Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae.	Iron	116-120	Nfu1p	Saccharomyces cerevisiae S288C	22-26
25156587-8	2014	Moreover, intravenous iron supplementation was encouraged earlier in Taiwan in 1996, when we reached consensus on the diagnostic criteria for iron deficiency (serum ferritin &lt;300 ng/mL and/or transferrin saturation &lt;30%).	Iron	22-26	transferrin	Homo sapiens	195-206
25653844-9	2014	Interestingly, we observed that intense illumination of six-coordinate ferrous iNOS oxy-NO ruptures the bond between the heme iron and the proximal thiolate to yield five-coordinate ferric iNOS oxy-NO, demonstrating the strong trans effect of the heme-bound NO.	Iron	126-130	nitric oxide synthase 2	Homo sapiens	79-83
25051259-9	2014	Furthermore, FP1 overexpression could attenuate Fe accumulation in Pb-exposed PC12 cells.	Iron	48-50	solute carrier family 40 member 1	Rattus norvegicus	13-16
25051259-10	2014	These results indicated that FP1 might be a novel target to prevent cellular Fe accumulation induced by Pb exposure and subsequent neurotoxic consequences.	Iron	77-79	solute carrier family 40 member 1	Rattus norvegicus	29-32
26483934-3	2014	The objective of this study was to review in the literature the relationship between iron metabolism and RLS.	Iron	85-89	RLS1	Homo sapiens	105-108
26483934-5	2014	Few studies were found for this review in the period of 2001-2014, however, the correlation between RLS and iron was evident.	Iron	108-112	RLS1	Homo sapiens	100-103
25653844-9	2014	Interestingly, we observed that intense illumination of six-coordinate ferrous iNOS oxy-NO ruptures the bond between the heme iron and the proximal thiolate to yield five-coordinate ferric iNOS oxy-NO, demonstrating the strong trans effect of the heme-bound NO.	Iron	126-130	nitric oxide synthase 2	Homo sapiens	189-193
25247461-6	2014	The analyses of the surface chemical composition of Fe3O4 by X-ray photoelectron spectroscopy (XPS) reveal that, upon the addition of NO2, the surface is oxidized and a contribution at 532.5 +- 0.4 eV in the O1s spectrum appears, showing that NO2 likely competes with toluene by dissociating on Fe(2+) sites and forming NO3(-).	Iron	52-54	NBL1, DAN family BMP antagonist	Homo sapiens	320-323
25398733-8	2014	Traditional indicators of iron, zinc, and vitamin A status are altered during the APR, leading to inaccurate estimations of deficiency in populations with a high or unknown prevalence of infection.	Iron	26-30	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	82-85
25239913-0	2014	Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.	Iron	120-124	toll-like receptor 4	Mus musculus	9-13
25170527-0	2014	Incorporation of (57)Fe-isotopically enriched in apoferritin: formation and characterization of isotopically enriched Fe nanoparticles for metabolic studies.	Iron	21-23	ferritin heavy chain	Equus caballus	49-60
25313991-0	2014	Reactivity of the binuclear non-heme iron active site of Delta9 desaturase studied by large-scale multireference ab initio calculations.	Iron	37-41	fatty acid desaturase 3	Homo sapiens	57-74
25385697-5	2014	Fe excess decreases primary root length in the same way in wild-type and in fer1-3-4 mutant.	Iron	0-2	ferretin 1	Arabidopsis thaliana	76-80
25385697-7	2014	We observe that this interaction between excess Fe, ferritin and RSA is in part mediated by the H2O2/O2.- balance between the root cell proliferation and differentiation zones regulated by the UPB1 transcription factor.	Iron	48-50	transcription factor UPBEAT protein	Arabidopsis thaliana	193-197
25390893-7	2014	RESULTS: Iron entered HL-1 cardiomyocytes in a time- and dose-dependent manner and induced cardiac apoptosis via mitochondria-mediated caspase-3 dependent pathways.	Iron	9-13	asialoglycoprotein receptor 1	Homo sapiens	22-26
25189925-9	2014	Plasma catalytic iron levels on ICU day 1 were significantly associated with in-hospital mortality or AKI requiring RRT, even after adjusting for age, enrollment eGFR, and number of packed red blood cell transfusions before ICU arrival (13 events; adjusted odds ratio per 1-SD higher ln[catalytic iron], 3.33; 95% confidence interval, 1.79 to 6.20).	Iron	17-21	epidermal growth factor receptor	Homo sapiens	162-166
25230250-0	2014	Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism.	Iron	74-78	endothelin 1	Homo sapiens	0-12
25170527-0	2014	Incorporation of (57)Fe-isotopically enriched in apoferritin: formation and characterization of isotopically enriched Fe nanoparticles for metabolic studies.	Iron	118-120	ferritin heavy chain	Equus caballus	49-60
25093806-10	2014	Additionally, increased IL-6 was demonstrated to jointly enhance the tumorigenic effects of iron through enforcing cell growth.	Iron	92-96	interleukin 6	Homo sapiens	24-28
25093426-0	2014	A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry.	Iron	41-45	transferrin	Homo sapiens	23-34
25093426-1	2014	The reliable measurement of non-transferrin-bound iron (NTBI) in serum has proved to be difficult and generally time consuming.	Iron	50-54	transferrin	Homo sapiens	32-43
24962609-2	2014	Iron activates prolyl hydroxylases (PHDs) and promotes the degradation of the alpha-subunit of hypoxia inducible factor (HIF), which regulates EPO production.	Iron	0-4	erythropoietin	Homo sapiens	143-146
24962609-5	2014	It is thought that iron influences EPO production by altering two pathways, namely PHDs activity and oxidative stress.	Iron	19-23	erythropoietin	Homo sapiens	35-38
25113195-5	2014	In the absence of soil, Pd-catalyzed treatments (Pd with electrolytic ZVI or iron/aluminum alloy) achieved rapid destruction of a model PCB congener, 2-chlorobiphenyl, with half-lives ranging from 43 to 110 min.	Iron	70-73	pyruvate carboxylase	Homo sapiens	136-139
25113195-5	2014	In the absence of soil, Pd-catalyzed treatments (Pd with electrolytic ZVI or iron/aluminum alloy) achieved rapid destruction of a model PCB congener, 2-chlorobiphenyl, with half-lives ranging from 43 to 110 min.	Iron	77-81	pyruvate carboxylase	Homo sapiens	136-139
25217696-5	2014	Normal hematopoietic cells showed elevated ROS levels through increased intracellular iron levels when treated with lipocalin-2, which led to p53 pathway activation, increased apoptosis, and decreased cellular proliferation.	Iron	86-90	tumor protein p53	Homo sapiens	142-145
27308524-0	2016	The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis.	Iron	34-38	tumor protein p53	Homo sapiens	9-12
27308524-0	2016	The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis.	Iron	34-38	tumor protein p53	Homo sapiens	53-56
25155598-0	2014	Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IkappaB-alpha expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.	Iron	36-40	NFKB inhibitor alpha	Homo sapiens	60-73
25155598-0	2014	Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IkappaB-alpha expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.	Iron	36-40	cyclin dependent kinase 9	Homo sapiens	104-108
25155598-3	2014	We previously showed that chelation of intracellular iron inhibits CDK2 and CDK9 activities and suppresses HIV-1 transcription, but the mechanism of the inhibition was not understood.	Iron	53-57	cyclin dependent kinase 9	Homo sapiens	76-80
25155598-7	2014	PPY-based iron chelators significantly inhibited HIV-1, with minimal cytotoxicity, in cultured and primary cells chronically or acutely infected with HIV-1 subtype B, but they had less of an effect on HIV-1 subtype C. Iron chelators upregulated the expression of IkappaB-alpha, with increased accumulation of cytoplasmic NF-kappaB.	Iron	10-14	NFKB inhibitor alpha	Homo sapiens	263-276
25155598-8	2014	The iron chelators inhibited CDK2 activity and reduced the amount of CDK9/cyclin T1 in the large P-TEFb complex.	Iron	4-8	cyclin dependent kinase 9	Homo sapiens	69-73
25155598-8	2014	The iron chelators inhibited CDK2 activity and reduced the amount of CDK9/cyclin T1 in the large P-TEFb complex.	Iron	4-8	cyclin T1	Homo sapiens	74-83
24889085-4	2014	As another example, solute carriers mediate control over the availability of endogenous metal ions, such as copper, iron and zinc, may have key roles in regulating tumour angiogenesis, cell proliferation, epithelial-to-mesenchymal transition and aberrant MAPK and STAT-3 signal transduction in cancer.	Iron	116-120	signal transducer and activator of transcription 3	Homo sapiens	264-270
24889971-1	2014	Iron uptake by the transferrin (Tf)-transferrin receptor (TfR) complex is critical for erythroid differentiation.	Iron	0-4	transferrin	Homo sapiens	19-30
24889971-1	2014	Iron uptake by the transferrin (Tf)-transferrin receptor (TfR) complex is critical for erythroid differentiation.	Iron	0-4	transferrin	Homo sapiens	36-47
25238731-11	2014	Intravenous iron inconsistently but sometimes considerably improves RLS and can be considered in refractory cases.	Iron	12-16	RLS1	Homo sapiens	68-71
25072389-0	2014	Non-transferrin-bound iron assay system utilizing a conventional automated analyzer.	Iron	22-26	transferrin	Homo sapiens	4-15
25072389-3	2014	However, when iron balance collapses, such as in prolonged transfusion, transferrin (Tf) is fully saturated and non-Tf-bound iron (NTBI) appears in the serum.	Iron	14-18	transferrin	Homo sapiens	72-83
25072389-3	2014	However, when iron balance collapses, such as in prolonged transfusion, transferrin (Tf) is fully saturated and non-Tf-bound iron (NTBI) appears in the serum.	Iron	14-18	transferrin	Homo sapiens	85-87
24801367-2	2014	This study examined the associations between the TMPRSS6 rs855791 polymorphism and iron indices at baseline and after a 12-month trial comparing two weight loss diets (higher-protein, higher-haem iron (HPHI) vs lower-protein, lower-haem iron (LPLI)).	Iron	83-87	transmembrane serine protease 6	Homo sapiens	49-56
24722448-3	2014	We found that expression levels of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and adhesion of U937 cells increased in iron-treated human aortic endothelial cells through upregulated NADPH oxidase (NOx) and NF-kappaB signaling.	Iron	170-174	vascular cell adhesion molecule 1	Homo sapiens	87-120
25168077-1	2014	The aim of this study was to examine whether alterations in iron homeostasis, caused by exposure to vanadium, are related to changes in the gene expression of hepatic hepcidin.	Iron	60-64	hepcidin antimicrobial peptide	Rattus norvegicus	167-175
25175826-5	2014	RESULTS: Significant changes in iron metabolism and markers of lipid and protein oxidation were detected in ALS I animals, which manifested as decreased levels of ferritin H and ferroportin 1 (Fpn1) and increased levels of ferritin L levels.	Iron	32-36	solute carrier family 40 member 1	Rattus norvegicus	178-191
25175826-8	2014	CONCLUSIONS: This study showed that multiple mechanisms may underlie iron accumulation in muscles of ALS transgenic rats, which include changes in blood hepcidin and muscle Fpn1 and increased level of muscle ferritin H. These data suggest that impaired iron metabolism is not a result of changes in motor activity.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	153-161
25175826-8	2014	CONCLUSIONS: This study showed that multiple mechanisms may underlie iron accumulation in muscles of ALS transgenic rats, which include changes in blood hepcidin and muscle Fpn1 and increased level of muscle ferritin H. These data suggest that impaired iron metabolism is not a result of changes in motor activity.	Iron	69-73	solute carrier family 40 member 1	Rattus norvegicus	173-177
25156943-0	2014	Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies.	Iron	60-64	transmembrane serine protease 6	Homo sapiens	40-47
25156943-1	2014	Iron-refractory iron-deficiency anemia (IRIDA) is a rare autosomal-recessive disorder characterized by hypochromic microcytic anemia, low transferrin saturation, and inappropriate high levels of the iron hormone hepcidin.	Iron	0-4	transferrin	Homo sapiens	138-149
25156943-1	2014	Iron-refractory iron-deficiency anemia (IRIDA) is a rare autosomal-recessive disorder characterized by hypochromic microcytic anemia, low transferrin saturation, and inappropriate high levels of the iron hormone hepcidin.	Iron	16-20	transferrin	Homo sapiens	138-149
25158131-0	2014	p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron.	Iron	153-157	tumor protein p53	Homo sapiens	0-3
25176568-7	2014	As a result, the intracellular labile iron pool (LIP) was largely reduced in THP-1 and HepG2 cells.	Iron	38-42	GLI family zinc finger 2	Homo sapiens	77-82
24722448-3	2014	We found that expression levels of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and adhesion of U937 cells increased in iron-treated human aortic endothelial cells through upregulated NADPH oxidase (NOx) and NF-kappaB signaling.	Iron	170-174	vascular cell adhesion molecule 1	Homo sapiens	122-128
25462017-2	2014	Both genes are homologs of the Ssq1 gene involved in Fe-S cluster assembly in yeast.	Iron	53-57	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	31-35
25332470-6	2014	RESULTS: High iron loading increased hepatic hepcidin by 3-fold and reduced duodenal expression of divalent metal transporter 1 (DMT1) by 76%.	Iron	14-18	hepcidin antimicrobial peptide	Rattus norvegicus	45-53
25332470-8	2014	Absorption of both forms of iron was inversely correlated with hepatic hepcidin expression (heme-iron absorption: r = -0.77, P = 0.003; nonheme-iron absorption: r = -0.80, P = 0.002), but hepcidin had a stronger impact on nonheme-iron absorption (P = 0.04).	Iron	28-32	hepcidin antimicrobial peptide	Rattus norvegicus	71-79
25017012-10	2014	This difference can be explained by redox processes involved during cycling of iron between transferrin and ferritin.	Iron	79-83	transferrin	Homo sapiens	92-103
25332470-8	2014	Absorption of both forms of iron was inversely correlated with hepatic hepcidin expression (heme-iron absorption: r = -0.77, P = 0.003; nonheme-iron absorption: r = -0.80, P = 0.002), but hepcidin had a stronger impact on nonheme-iron absorption (P = 0.04).	Iron	28-32	hepcidin antimicrobial peptide	Rattus norvegicus	188-196
25332470-8	2014	Absorption of both forms of iron was inversely correlated with hepatic hepcidin expression (heme-iron absorption: r = -0.77, P = 0.003; nonheme-iron absorption: r = -0.80, P = 0.002), but hepcidin had a stronger impact on nonheme-iron absorption (P = 0.04).	Iron	97-101	hepcidin antimicrobial peptide	Rattus norvegicus	71-79
25332470-8	2014	Absorption of both forms of iron was inversely correlated with hepatic hepcidin expression (heme-iron absorption: r = -0.77, P = 0.003; nonheme-iron absorption: r = -0.80, P = 0.002), but hepcidin had a stronger impact on nonheme-iron absorption (P = 0.04).	Iron	97-101	hepcidin antimicrobial peptide	Rattus norvegicus	71-79
25332470-8	2014	Absorption of both forms of iron was inversely correlated with hepatic hepcidin expression (heme-iron absorption: r = -0.77, P = 0.003; nonheme-iron absorption: r = -0.80, P = 0.002), but hepcidin had a stronger impact on nonheme-iron absorption (P = 0.04).	Iron	97-101	hepcidin antimicrobial peptide	Rattus norvegicus	71-79
25332470-10	2014	CONCLUSIONS: Elevated hepcidin significantly decreased heme- and nonheme-iron absorption but had a greater impact on nonheme-iron absorption.	Iron	73-77	hepcidin antimicrobial peptide	Rattus norvegicus	22-30
25332470-10	2014	CONCLUSIONS: Elevated hepcidin significantly decreased heme- and nonheme-iron absorption but had a greater impact on nonheme-iron absorption.	Iron	125-129	hepcidin antimicrobial peptide	Rattus norvegicus	22-30
24905399-5	2014	Upon targeting using transferrin ligands, the nanoparticles showed enhanced cellular uptake and synergistic cytotoxicity in ~92% of cells, particularly in iron-deficient microenvironment.	Iron	155-159	transferrin	Homo sapiens	21-32
24846416-8	2014	Examples of iron deposits were also observed in association with eNOS and iNOS, which could be one source of substrates for this reaction.	Iron	12-16	nitric oxide synthase 2, inducible	Mus musculus	74-78
25279183-10	2014	As serum iron and hepcidin-25 were both significantly increased and IL-6 was significantly decreased, with no significant changes in sTfR, it appears that the elevation of serum iron during chemotherapy may be secondary to reduced iron consumption by erythropoiesis, leading to increased expression of hepcidin-25 and suppression of Il-6 via negative feedback.	Iron	178-182	interleukin 6	Homo sapiens	333-337
25279183-10	2014	As serum iron and hepcidin-25 were both significantly increased and IL-6 was significantly decreased, with no significant changes in sTfR, it appears that the elevation of serum iron during chemotherapy may be secondary to reduced iron consumption by erythropoiesis, leading to increased expression of hepcidin-25 and suppression of Il-6 via negative feedback.	Iron	178-182	interleukin 6	Homo sapiens	333-337
25326704-1	2014	Members of the SLC11 (NRAMP) family transport iron and other transition-metal ions across cellular membranes.	Iron	46-50	solute carrier family 11 member 1	Homo sapiens	22-27
25329962-2	2014	The effect was seen originally with 600 MeV/u (56)Fe particles, which have a linear energy transfer (LET) value of 174 keV/mum, but not with X rays or gamma rays (LET &lt;= 2 keV/mum).	Iron	50-52	latexin	Homo sapiens	123-126
25329962-2	2014	The effect was seen originally with 600 MeV/u (56)Fe particles, which have a linear energy transfer (LET) value of 174 keV/mum, but not with X rays or gamma rays (LET &lt;= 2 keV/mum).	Iron	50-52	latexin	Homo sapiens	179-182
25036548-11	2014	Pellets containing iron-labeled cells expressed COL2A1 on protein level (all time points), in similar levels as controls, and glycosaminoglycan accumulation was observed in iron-labeled pellets (day 14 or day 28).	Iron	19-23	collagen type II alpha 1 chain	Homo sapiens	48-54
25196843-1	2014	Heme oxygenase (HO) catalyzes the rate-limiting step in the O2-dependent degradation of heme to biliverdin, CO, and iron with electrons delivered from NADPH via cytochrome P450 reductase (CPR).	Iron	116-120	cytochrome p450 oxidoreductase	Homo sapiens	161-186
25196843-1	2014	Heme oxygenase (HO) catalyzes the rate-limiting step in the O2-dependent degradation of heme to biliverdin, CO, and iron with electrons delivered from NADPH via cytochrome P450 reductase (CPR).	Iron	116-120	cytochrome p450 oxidoreductase	Homo sapiens	188-191
30363918-0	2014	7-Tesla Magnetic Resonance Imaging for Brain Iron Quantification in Homozygous and Heterozygous PANK2 Mutation Carriers.	Iron	45-49	pantothenate kinase 2	Homo sapiens	96-101
30363918-1	2014	Pantothenate-kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder characterized by iron deposits in basal ganglia.	Iron	108-112	pantothenate kinase 2	Homo sapiens	0-48
30363918-1	2014	Pantothenate-kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder characterized by iron deposits in basal ganglia.	Iron	108-112	pantothenate kinase 2	Homo sapiens	50-54
30363918-2	2014	The aim of this study was to quantify iron concentrations of deep gray matter structures in heterozygous PANK2 mutation carriers and in PKAN patients using quantitative susceptibility mapping MRI.	Iron	38-42	pantothenate kinase 2	Homo sapiens	105-110
30363918-3	2014	By determining iron concentration, we intended to find mutation-specific brain parenchymal stigmata in heterozygous PANK2 mutation carriers in comparison to age-matched healthy volunteers.	Iron	15-19	pantothenate kinase 2	Homo sapiens	116-121
30363918-10	2014	In PKAN patients, more than 3 times higher concentrations of iron were found in the GP, SN, and IC.	Iron	61-65	pantothenate kinase 2	Homo sapiens	3-7
25170082-9	2014	Three roles for His-19 in HCCS-mediated assembly are suggested: (i) to provide the second axial ligand to the heme iron in preparation for covalent attachment; (ii) to spatially position the two cysteinyl sulfurs adjacent to the two heme vinyl groups for thioether formation; and (iii) to aid in release of the holocytochrome c from the HCCS active site.	Iron	115-119	holocytochrome c synthase	Homo sapiens	26-30
25558243-5	2014	Furthermore, after AK-7 (a selective Sirtuin 2 inhibitor) was injected into the substantia nigra at postnatal 540 days and 570 days (5 mug/side per day), striatal dopamine depletion was significantly diminished and behavior abnormality was improved in aging rats with neonatal iron intake.	Iron	277-281	adenylate kinase 7	Rattus norvegicus	19-23
25360591-8	2014	The seed Fe concentration in the nramp3/nramp4 mutant overexpressing AtVTL1, AtVTL2 or AtVTL5 was between 50 and 60% higher than in non-transformed double mutants or wild-type plants.	Iron	9-11	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	87-93
25356756-7	2014	Raman spectroscopy analysis and immunoblotting indicated that in mitochondria from SSQ1 and ISA1 mutants, the content of [Fe-S] centers was decreased, as was formation of Rieske protein-dependent supercomplex III2IV2, but this was not observed in the iron-deficient ATX1 and MRS4 mutants.	Iron	251-255	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	83-87
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	transmembrane serine protease 6	Homo sapiens	130-137
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	fatty acid desaturase 2	Homo sapiens	169-174
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	testis expressed 14, intercellular bridge forming factor	Homo sapiens	182-187
25252141-7	2014	Thus, the evidence supports Compound I and not ferric peroxide as the active iron species in the third step of the steroid aromatase reaction.	Iron	77-81	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	123-132
25194416-1	2014	Production of nitric oxide (NO) by nitric oxide synthase (NOS) requires electrons to reduce the heme iron for substrate oxidation.	Iron	101-105	nitric oxide synthase 2	Homo sapiens	35-56
25193872-1	2014	Erythroferrone (ERFE) is an erythropoiesis-driven regulator of iron homeostasis.	Iron	63-67	erythroferrone	Mus musculus	16-20
25193872-2	2014	ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores.	Iron	37-41	erythroferrone	Mus musculus	0-4
25193872-2	2014	ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores.	Iron	82-86	erythroferrone	Mus musculus	0-4
25193872-9	2014	Thus, ERFE contributes to the recovery from AI by suppressing hepcidin and increasing iron availability.	Iron	86-90	erythroferrone	Mus musculus	6-10
24960650-0	2014	On the source of the non-transferrin-bound iron which accumulates in packed red blood cell units during storage.	Iron	43-47	transferrin	Homo sapiens	25-36
25290693-0	2014	Pyrophosphate-mediated iron acquisition from transferrin in Neisseria meningitidis does not require TonB activity.	Iron	23-27	serotransferrin	Bos taurus	45-56
25290693-2	2014	Outside the cells, iron is bound to transferrin in serum, or to lactoferrin in mucosal secretions.	Iron	19-23	serotransferrin	Bos taurus	36-47
25290693-3	2014	Meningococci can extract iron from iron-loaded human transferrin by the TbpA/TbpB outer membrane complex.	Iron	25-29	transferrin	Homo sapiens	53-64
25290693-3	2014	Meningococci can extract iron from iron-loaded human transferrin by the TbpA/TbpB outer membrane complex.	Iron	35-39	transferrin	Homo sapiens	53-64
25290693-9	2014	Pyrophosphate was shown to participate in iron transfer from transferrin to ferritin.	Iron	42-46	serotransferrin	Bos taurus	61-72
25290693-13	2014	Finally, we show that pyrophosphate enabled TonB-independent ex vivo use of iron-loaded human or bovine transferrin as an iron source by N. meningitidis.	Iron	76-80	serotransferrin	Bos taurus	104-115
25290693-13	2014	Finally, we show that pyrophosphate enabled TonB-independent ex vivo use of iron-loaded human or bovine transferrin as an iron source by N. meningitidis.	Iron	122-126	serotransferrin	Bos taurus	104-115
25122757-5	2014	ALKBH7 possesses the conserved double-stranded beta-helix fold that coordinates a catalytically active iron by a conserved HX(D/E) ... Xn ... H motif.	Iron	103-107	alkB homolog 7	Homo sapiens	0-6
24590680-9	2014	Serum IL-6, key factor in inflammatory and iron homeostasis disorders, was detected at enrolment and after therapy at delivery.	Iron	43-47	interleukin 6	Homo sapiens	6-10
25310285-6	2014	Elemental analysis showed a 60% and 80% reduction of iron uptake in control and wbc19 mutant seedlings respectively, upon exposure to kanamycin.	Iron	53-57	white-brown complex homolog 19	Arabidopsis thaliana	80-85
25088928-0	2014	Iron-catalyzed C(sp2)-H alkylation of carboxamides with primary electrophiles.	Iron	0-4	Sp2 transcription factor	Homo sapiens	15-20
24972132-5	2014	Iron status was assessed by serum ferritin, haemoglobin, soluble transferrin receptor and alpha-1-glycoprotein.	Iron	0-4	transferrin	Homo sapiens	65-76
24960650-1	2014	BACKGROUND: Recent studies have shown large increases in non-transferrin-bound iron (NTBI) and biomarkers of oxidative stress in the extracellular medium of packed red blood cell units during storage.	Iron	79-83	transferrin	Homo sapiens	61-72
24853299-2	2014	Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Abeta aggregation.	Iron	16-20	amyloid beta precursor protein	Homo sapiens	102-127
24853299-2	2014	Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Abeta aggregation.	Iron	25-29	amyloid beta precursor protein	Homo sapiens	102-127
26461324-13	2014	These data indicate that aconitase - and particularly the mitochondrial form - is a target for MPO-mediated damage with HOSCN showing a selectivity for the [4Fe-4S] cluster and inducing greater iron release.	Iron	194-198	myeloperoxidase	Homo sapiens	95-98
25048971-7	2014	Recent evidence also indicates that ascorbate is a novel modulator of the classical transferrin-iron uptake pathway, which provides almost all iron for cellular demands and erythropoiesis under physiological conditions.	Iron	96-100	transferrin	Homo sapiens	84-95
25048971-7	2014	Recent evidence also indicates that ascorbate is a novel modulator of the classical transferrin-iron uptake pathway, which provides almost all iron for cellular demands and erythropoiesis under physiological conditions.	Iron	143-147	transferrin	Homo sapiens	84-95
25048971-8	2014	Ascorbate acts to stimulate transferrin-dependent iron uptake by an intracellular reductive mechanism, strongly suggesting that it may act to stimulate iron mobilization from the endosome.	Iron	50-54	transferrin	Homo sapiens	28-39
25048971-8	2014	Ascorbate acts to stimulate transferrin-dependent iron uptake by an intracellular reductive mechanism, strongly suggesting that it may act to stimulate iron mobilization from the endosome.	Iron	152-156	transferrin	Homo sapiens	28-39
25048971-9	2014	The ability of ascorbate to regulate transferrin iron uptake could help explain the metabolic defect that contributes to ascorbate-deficiency-induced anemia.	Iron	49-53	transferrin	Homo sapiens	37-48
26461324-14	2014	This damage, and the release of iron, may exacerbate oxidative stress in cells at sites of inflammation where active MPO is present.	Iron	32-36	myeloperoxidase	Homo sapiens	117-120
24845066-10	2014	The main difference in the prevalence of patients receiving a PIM according to the two versions of Beers" criteria involved prescriptions of benzodiazepines for insomnia or agitation, chronic use of non-benzodiazepine hypnotics, prescription of antipsychotics in people with dementia and oral iron at dosage higher than 325 mg/day.	Iron	293-297	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	62-65
25074810-0	2014	Moonlighting cell-surface GAPDH recruits apotransferrin to effect iron egress from mammalian cells.	Iron	66-70	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	26-31
24777275-9	2014	CONCLUSION: Our biochemical study provides evidence that altered iron homeostasis within the brain occurs in the very early phases of the disease, and suggests that the transporter protein transferrin may play a role in the increased iron deposition known to occur in the brain of MS patients.	Iron	65-69	transferrin	Homo sapiens	189-200
25080540-9	2014	EPO is a sensitive indicator of iron status across gestation, is not affected by systemic inflammation, and may better predict risk of anemia at term.	Iron	32-36	erythropoietin	Homo sapiens	0-3
24777275-9	2014	CONCLUSION: Our biochemical study provides evidence that altered iron homeostasis within the brain occurs in the very early phases of the disease, and suggests that the transporter protein transferrin may play a role in the increased iron deposition known to occur in the brain of MS patients.	Iron	234-238	transferrin	Homo sapiens	189-200
25229976-4	2014	In this study, we compared the clonogenic survival frequency of Ku80+/+ (NHEJ-proficient) and Ku80-/- (NHEJ-deficient) cells after exposure to iron (175 keV/mum), silicon (75 keV/mum), oxygen (25 keV/mum) and X ray (low-LET).	Iron	143-147	latexin	Homo sapiens	157-160
24710655-10	2014	Day 5 non-transferrin bound iron (NTBI) (7.88 +- 1 vs. 3.58 +- 0.8, p = 0.02) and mean NTBI (7.39 +- 0.4 vs. 3.34 + 0.4 p = 0.03) were significantly higher in patients who developed DCI.	Iron	28-32	transferrin	Homo sapiens	10-21
25074810-4	2014	Previous studies have revealed that iron-depleted cells recruit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a multitasking, "moonlighting" protein, to their surface for internalization of the iron carrier holotransferrin.	Iron	36-40	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	64-104
25074810-4	2014	Previous studies have revealed that iron-depleted cells recruit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a multitasking, "moonlighting" protein, to their surface for internalization of the iron carrier holotransferrin.	Iron	36-40	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	106-111
25074810-4	2014	Previous studies have revealed that iron-depleted cells recruit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a multitasking, "moonlighting" protein, to their surface for internalization of the iron carrier holotransferrin.	Iron	198-202	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	64-104
25074810-4	2014	Previous studies have revealed that iron-depleted cells recruit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a multitasking, "moonlighting" protein, to their surface for internalization of the iron carrier holotransferrin.	Iron	198-202	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	106-111
25074810-5	2014	Here, we report that under the converse condition of intracellular iron excess, cells switch the isoform of GAPDH on their surface to one that now recruits iron-free apotransferrin in close association with ferroportin to facilitate the efflux of iron.	Iron	67-71	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	108-113
25074810-5	2014	Here, we report that under the converse condition of intracellular iron excess, cells switch the isoform of GAPDH on their surface to one that now recruits iron-free apotransferrin in close association with ferroportin to facilitate the efflux of iron.	Iron	156-160	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	108-113
25074810-5	2014	Here, we report that under the converse condition of intracellular iron excess, cells switch the isoform of GAPDH on their surface to one that now recruits iron-free apotransferrin in close association with ferroportin to facilitate the efflux of iron.	Iron	156-160	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	108-113
25074810-6	2014	Increased expression of surface GAPDH correlated with increased apotransferrin binding and enhanced iron export from cells, a capability lost in GAPDH-knockdown cells.	Iron	100-104	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	32-37
25085935-5	2014	Hydrolyzing ovalbumin with pepsin (OAPe), pepsin + papain (OAPePa), pepsin + alcalase (OAPeAl), alcalase + trypsin (OAAlTr), and alpha-chymotrypsin (OACh) was also effective in producing peptides from ovalbumin, and the peptides produced had strong iron- and copper-binding capacities and antioxidant capability.	Iron	249-253	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	12-21
24953684-0	2014	A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin.	Iron	140-144	transferrin	Homo sapiens	158-169
25261367-0	2014	The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.	Iron	4-8	signal transducer and activator of transcription 3	Homo sapiens	122-127
25197096-5	2014	We used an FWA-GFP reporter to find mutants defective in maternal activation of FWA-GFP in the EDL, and isolated an allele of the yeast Dre2/human antiapoptotic factor CIAPIN1 homolog, encoding an enzyme previously implicated in the cytosolic Fe-S biogenesis pathway (CIA), which we named atdre2-2.	Iron	243-247	electron carrier DRE2	Saccharomyces cerevisiae S288C	136-140
25380935-5	2014	Taking into consideration iron metabolism, including its absorption in the gut, the aim of this study was to assess zonulin levels in heart transplant recipients and their possible correlations with iron status, immunosuppressive therapy, and kidney function.	Iron	26-30	haptoglobin	Homo sapiens	116-123
25380935-5	2014	Taking into consideration iron metabolism, including its absorption in the gut, the aim of this study was to assess zonulin levels in heart transplant recipients and their possible correlations with iron status, immunosuppressive therapy, and kidney function.	Iron	199-203	haptoglobin	Homo sapiens	116-123
25247420-2	2014	However, little is known about how copper deficiency affects iron homeostasis through alteration of the activity of other copper-containing proteins, not directly connected with iron metabolism, such as superoxide dismutase 1 (SOD1).	Iron	61-65	superoxide dismutase 1, soluble	Mus musculus	227-231
25222563-0	2014	Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli.	Iron	86-90	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	12-15
25222563-1	2014	The ferric uptake regulator (Fur) plays a critical role in the transcriptional regulation of iron metabolism.	Iron	93-97	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	29-32
25222563-3	2014	Here we comprehensively reconstruct the Fur transcriptional regulatory network in Escherichia coli K-12 MG1655 in response to iron availability using genome-wide measurements.	Iron	126-130	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	40-43
25222563-5	2014	We show that Fur connects iron transport and utilization enzymes with negative-feedback loop pairs for iron homeostasis.	Iron	26-30	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	13-16
25222563-5	2014	We show that Fur connects iron transport and utilization enzymes with negative-feedback loop pairs for iron homeostasis.	Iron	103-107	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	13-16
25222563-7	2014	These results show how Fur exhibits a comprehensive regulatory role affecting many fundamental cellular processes linked to iron metabolism in order to coordinate the overall response of E. coli to iron availability.	Iron	124-128	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	23-26
25222563-7	2014	These results show how Fur exhibits a comprehensive regulatory role affecting many fundamental cellular processes linked to iron metabolism in order to coordinate the overall response of E. coli to iron availability.	Iron	198-202	DNA-binding transcriptional dual regulator Fur	Escherichia coli str. K-12 substr. MG1655	23-26
24953684-6	2014	Furthermore, we succeeded in monitoring the accumulation of labile iron in the lysosome induced by transferrin-mediated endocytosis with a turn-on fluorescence response.	Iron	67-71	transferrin	Homo sapiens	99-110
25215659-1	2014	Iron homeostasis is affected by obesity and obesity-related insulin resistance in a many-facetted fashion.	Iron	0-4	insulin	Homo sapiens	60-67
24111776-5	2014	Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.	Iron	53-55	iron-sulfur cluster assembly enzyme	Homo sapiens	85-89
24111776-5	2014	Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.	Iron	53-55	glycerol-3-phosphate dehydrogenase 1 like	Homo sapiens	95-136
24111776-5	2014	Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.	Iron	53-55	glycerol-3-phosphate dehydrogenase 1 like	Homo sapiens	138-143
25057155-0	2014	Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: a randomized study.	Iron	34-38	transferrin	Homo sapiens	16-27
25132469-5	2014	Additionally, iron that accumulates in macrophages in SCI increases TNF expression and the appearance of a macrophage population with a proinflammatory mixed M1/M2 phenotype.	Iron	14-18	tumor necrosis factor	Homo sapiens	68-71
25057155-1	2014	BACKGROUND: After the oral administration of iron, the production of circulating non-transferrin-bound iron may contribute to an increased risk of illness in malaria-endemic areas that lack effective medical services.	Iron	45-49	transferrin	Homo sapiens	85-96
25057155-1	2014	BACKGROUND: After the oral administration of iron, the production of circulating non-transferrin-bound iron may contribute to an increased risk of illness in malaria-endemic areas that lack effective medical services.	Iron	103-107	transferrin	Homo sapiens	85-96
25057155-5	2014	For the 60 mg Fe without food, the area under the curve over 8 h for serum non-transferrin-bound iron was positively correlated with the amount of iron absorbed (R = 0.49, P &lt; 0.01) and negatively correlated with serum ferritin (R = -0.39, P &lt; 0.05).	Iron	14-16	transferrin	Homo sapiens	79-90
25057155-5	2014	For the 60 mg Fe without food, the area under the curve over 8 h for serum non-transferrin-bound iron was positively correlated with the amount of iron absorbed (R = 0.49, P &lt; 0.01) and negatively correlated with serum ferritin (R = -0.39, P &lt; 0.05).	Iron	97-101	transferrin	Homo sapiens	79-90
25057155-5	2014	For the 60 mg Fe without food, the area under the curve over 8 h for serum non-transferrin-bound iron was positively correlated with the amount of iron absorbed (R = 0.49, P &lt; 0.01) and negatively correlated with serum ferritin (R = -0.39, P &lt; 0.05).	Iron	147-151	transferrin	Homo sapiens	79-90
25057155-6	2014	CONCLUSIONS: In healthy women, the production of circulating non-transferrin-bound iron is determined by the rate and amount of iron absorbed.	Iron	83-87	transferrin	Homo sapiens	65-76
25057155-6	2014	CONCLUSIONS: In healthy women, the production of circulating non-transferrin-bound iron is determined by the rate and amount of iron absorbed.	Iron	128-132	transferrin	Homo sapiens	65-76
25057155-7	2014	The highest concentrations of non-transferrin-bound iron resulted from the administration of supplemental doses of iron without food.	Iron	52-56	transferrin	Homo sapiens	34-45
25057155-7	2014	The highest concentrations of non-transferrin-bound iron resulted from the administration of supplemental doses of iron without food.	Iron	115-119	transferrin	Homo sapiens	34-45
24820446-0	2014	Age-related iron deposition in the basal ganglia of controls and Alzheimer disease patients quantified using susceptibility weighted imaging.	Iron	12-16	renin binding protein	Homo sapiens	0-3
24820446-1	2014	This study aimed to investigate age-related iron deposition changes in healthy subjects and Alzheimer disease patients using susceptibility weighted imaging.	Iron	44-48	renin binding protein	Homo sapiens	32-35
24820446-6	2014	We hypothesized that age-related iron deposition changes may be different between Alzheimer disease patients and controls of the same age, and that susceptibility weighted imaging would be a more sensitive method of iron deposition quantification.	Iron	33-37	renin binding protein	Homo sapiens	21-24
24820446-6	2014	We hypothesized that age-related iron deposition changes may be different between Alzheimer disease patients and controls of the same age, and that susceptibility weighted imaging would be a more sensitive method of iron deposition quantification.	Iron	33-37	renin binding protein	Homo sapiens	134-137
24820446-7	2014	The results revealed that iron deposition in the globus pallidus increased with age, up to 40 years.	Iron	26-30	renin binding protein	Homo sapiens	80-83
24820446-11	2014	In conclusion, iron deposition increased with age in the globus pallidus, the head of the caudate nucleus and putamen, reaching a plateau at different ages.	Iron	15-19	renin binding protein	Homo sapiens	46-49
24973963-10	2014	Palmitate administration also led to a state of functional intracellular iron deficiency, with decreased Tf gene expression and iron uptake during adipocyte differentiation, which was reversed with transferrin co-treatment.	Iron	73-77	transferrin	Homo sapiens	198-209
24972167-1	2014	BACKGROUND: Transferrin is an iron-binding blood plasma glycoprotein that controls the level of free iron in biological fluids.	Iron	30-34	transferrin	Homo sapiens	12-23
24972167-1	2014	BACKGROUND: Transferrin is an iron-binding blood plasma glycoprotein that controls the level of free iron in biological fluids.	Iron	101-105	transferrin	Homo sapiens	12-23
24568186-8	2014	We speculated that iron, a by-product of HO-1-catalyzed reactions, could mediate 15d-PGJ2-induced p53 expression.	Iron	19-23	tumor protein p53	Homo sapiens	98-101
24568186-9	2014	Upregulation of p53 expression by 15d-PGJ2 was abrogated by the iron chelator desferrioxamine in MCF-7 cells.	Iron	64-68	tumor protein p53	Homo sapiens	16-19
24568186-13	2014	In conclusion, upregulation of p53 and p21 via HO-1 induction and subsequent release of iron with accumulation of H-ferritin may confer resistance to oxidative damage in cancer cells frequently challenged by redox-cycling anticancer drugs.	Iron	88-92	tumor protein p53	Homo sapiens	31-34
24895335-6	2014	Combined treatment with an erythropoiesis-stimulating agent and an inhibitor of hepcidin expression, LDN-193189, significantly reduced serum hepcidin levels, mobilized iron from tissue stores, increased serum iron levels and improved hemoglobin levels more effectively than did the erythropoiesis-stimulating agent or LDN-193189 monotherapy.	Iron	168-172	hepcidin antimicrobial peptide	Rattus norvegicus	80-88
24895335-6	2014	Combined treatment with an erythropoiesis-stimulating agent and an inhibitor of hepcidin expression, LDN-193189, significantly reduced serum hepcidin levels, mobilized iron from tissue stores, increased serum iron levels and improved hemoglobin levels more effectively than did the erythropoiesis-stimulating agent or LDN-193189 monotherapy.	Iron	209-213	hepcidin antimicrobial peptide	Rattus norvegicus	80-88
24976419-0	2014	Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin.	Iron	42-46	mechanistic target of rapamycin kinase	Homo sapiens	0-29
24980968-9	2014	Iron chelation by excess Ent or Ybt significantly increased Lcn2-induced secretion of IL-8, IL-6, and CCL20.	Iron	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
24980968-9	2014	Iron chelation by excess Ent or Ybt significantly increased Lcn2-induced secretion of IL-8, IL-6, and CCL20.	Iron	0-4	interleukin 6	Homo sapiens	92-96
25184561-5	2014	Evidence suggests that specialized shell proteins conduct electrons between the cytoplasm and the lumen of the MCP and/or help rebuild damaged iron-sulfur centers in the encapsulated enzymes.	Iron	143-147	CD46 molecule	Homo sapiens	111-114
25238834-15	2014	In conclusion, iron may stimulate the expression of pro-inflammatory genes (TNF-alpha and IL- 6), and both hepcidin and ferritin gene expression levels could be a risk factor for the development of type 2 diabetes.	Iron	15-19	tumor necrosis factor	Homo sapiens	76-85
25238834-15	2014	In conclusion, iron may stimulate the expression of pro-inflammatory genes (TNF-alpha and IL- 6), and both hepcidin and ferritin gene expression levels could be a risk factor for the development of type 2 diabetes.	Iron	15-19	interleukin 6	Homo sapiens	90-95
24806658-1	2014	PURPOSE: Disturbed iron homeostasis contributes to resistance to recombinant human erythropoietin (rHuEpo) in hemodialysis (HD) patients.	Iron	19-23	erythropoietin	Homo sapiens	83-97
24976419-0	2014	Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin.	Iron	63-67	mechanistic target of rapamycin kinase	Homo sapiens	0-29
24976419-4	2014	The mammalian target of rapamycin (mTOR), an atypical Ser/Thr protein kinase, is attracting significant amounts of interest due to its recently described role in iron homeostasis.	Iron	162-166	mechanistic target of rapamycin kinase	Homo sapiens	4-33
24976419-4	2014	The mammalian target of rapamycin (mTOR), an atypical Ser/Thr protein kinase, is attracting significant amounts of interest due to its recently described role in iron homeostasis.	Iron	162-166	mechanistic target of rapamycin kinase	Homo sapiens	35-39
24976419-8	2014	Moreover, mTOR is reported to control iron metabolism through modulation of tristetraprolin expression.	Iron	38-42	mechanistic target of rapamycin kinase	Homo sapiens	10-14
24976419-10	2014	Sustained ISCU protein levels enhanced by mTORC1 can inhibit iron-responsive element and iron-regulatory protein binding activities.	Iron	61-65	iron-sulfur cluster assembly enzyme	Homo sapiens	10-14
24976419-12	2014	Here, we highlight and summarize the current understanding of how mTOR pathways serve to modulate iron metabolism and homeostasis as the third iron-regulatory system.	Iron	98-102	mechanistic target of rapamycin kinase	Homo sapiens	66-70
24976419-12	2014	Here, we highlight and summarize the current understanding of how mTOR pathways serve to modulate iron metabolism and homeostasis as the third iron-regulatory system.	Iron	143-147	mechanistic target of rapamycin kinase	Homo sapiens	66-70
24917298-2	2014	Here, we have combined experimental and computational methods to study the stability of IscU, a bacterial scaffold protein highly conserved in most organisms and an essential component of the iron-sulfur cluster biogenesis pathway.	Iron	192-196	iron-sulfur cluster assembly enzyme	Homo sapiens	88-92
25079612-3	2014	The effect of soy protein (SP) and Ca content on Fe, Zn, and Ca bioaccessibility and protein digestibility (%DP) was assessed using a response surface design in EF.	Iron	49-51	coagulation factor VII	Homo sapiens	14-37
24947444-0	2014	Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status.	Iron	83-87	LDL receptor related protein 1	Homo sapiens	24-28
24947444-3	2014	Little is known about systemic concentrations of Hx during pregnancy and whether maternal Hx and placental LRP1 contributes to fetal iron (Fe) homeostasis during pregnancy.	Iron	133-137	LDL receptor related protein 1	Homo sapiens	107-111
24947444-5	2014	Placental LRP1 expression was assessed in 57 pregnant adolescents (14-18 years) in relationship with maternal and cord blood Fe status indicators (hemoglobin (Hb), serum ferritin, transferrin receptor), the Fe regulatory hormone hepcidin and serum Hx.	Iron	125-127	LDL receptor related protein 1	Homo sapiens	10-14
25007760-2	2014	4-Arylquinoline 2-carboxylates 1o and 1q displayed significant antioxidant activity as indicated by their Fe-reducing power in the ferric reducing ability of plasma (FRAP) assay.	Iron	106-108	mechanistic target of rapamycin kinase	Homo sapiens	166-170
25117622-10	2014	However, tumorigenesis in the energetic iron-ion exposed group was reduced ~8-fold in APC(Min/+)/Wip1(-/-) relative to APC(Min/+)/Wip1(+/+) mice.	Iron	40-44	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	97-101
25117622-10	2014	However, tumorigenesis in the energetic iron-ion exposed group was reduced ~8-fold in APC(Min/+)/Wip1(-/-) relative to APC(Min/+)/Wip1(+/+) mice.	Iron	40-44	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	130-134
25117622-11	2014	A significantly lower proliferation/differentiation index in tumors of iron-ion exposed APC(Min/+)/Wip1(-/-) relative to APC(Min/+)/Wip1(+/+) mice suggests that reduced proliferation and enhanced differentiation as a result of Wip1 abrogation maybe involved.	Iron	71-75	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	99-103
25093545-7	2014	When the molar ratio of Fe to Ce was 5:1, the product with uniform nanostructured hollow architectures exhibited the best adsorption capacities for both As(V) and As(III) (206.6 and 266.0 mg g(-1), respectively).	Iron	24-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	153-158
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	35-39	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	124-131
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	41-43	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	124-131
24854545-7	2014	Iron uptake and subsequent ferritin expression were suppressed by either DMT1 or PCBP2 knockdown.	Iron	0-4	poly(rC) binding protein 2	Homo sapiens	81-86
25002578-10	2014	Our data suggest that iron deficiency increases liver miR-130a, which, by targeting ALK2, may contribute to reduce BMP-SMAD signaling, suppress hepcidin synthesis, and thereby promote iron availability.	Iron	22-26	microRNA 130a	Mus musculus	54-62
25054239-6	2014	Previously, we proposed a four-step model describing HCCS-mediated cytochrome c assembly, identifying a conserved histidine residue (His154) as an axial ligand to the heme iron.	Iron	172-176	holocytochrome c synthase	Homo sapiens	53-57
25054239-6	2014	Previously, we proposed a four-step model describing HCCS-mediated cytochrome c assembly, identifying a conserved histidine residue (His154) as an axial ligand to the heme iron.	Iron	172-176	cytochrome c, somatic	Homo sapiens	67-79
24854545-9	2014	These results indicate that ferrous iron imported by DMT1 is transferred directly to PCBP2.	Iron	36-40	poly(rC) binding protein 2	Homo sapiens	85-90
24854545-10	2014	Moreover, we demonstrated that PCBP2 could bind to ferroportin, which exports ferrous iron out of the cell.	Iron	86-90	poly(rC) binding protein 2	Homo sapiens	31-36
25163484-0	2014	Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin.	Iron	36-40	transferrin	Homo sapiens	105-116
25163484-1	2014	Mycobacterium tuberculosis (M.tb), which requires iron for survival, acquires this element by synthesizing iron-binding molecules known as siderophores and by recruiting a host iron-transport protein, transferrin, to the phagosome.	Iron	50-54	transferrin	Homo sapiens	201-212
25163484-1	2014	Mycobacterium tuberculosis (M.tb), which requires iron for survival, acquires this element by synthesizing iron-binding molecules known as siderophores and by recruiting a host iron-transport protein, transferrin, to the phagosome.	Iron	107-111	transferrin	Homo sapiens	201-212
25163484-2	2014	The siderophores extract iron from transferrin and transport it into the bacterium.	Iron	25-29	transferrin	Homo sapiens	35-46
25163484-3	2014	Here we describe an additional mechanism for iron acquisition, consisting of an M.tb protein that drives transport of human holo-transferrin into M.tb cells.	Iron	45-49	transferrin	Homo sapiens	129-140
25163484-6	2014	Overexpression of GAPDH results in increased transferrin binding to M.tb cells and iron uptake.	Iron	83-87	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	18-23
24854545-11	2014	These findings suggest that PCBP2 can transfer ferrous iron from DMT1 to the appropriate intracellular sites or ferroportin and could function as an iron chaperone.	Iron	55-59	poly(rC) binding protein 2	Homo sapiens	28-33
24854545-11	2014	These findings suggest that PCBP2 can transfer ferrous iron from DMT1 to the appropriate intracellular sites or ferroportin and could function as an iron chaperone.	Iron	149-153	poly(rC) binding protein 2	Homo sapiens	28-33
24854545-8	2014	Iron-associated DMT1 could interact with PCBP2 in vitro, whereas iron-chelated DMT1 could not.	Iron	0-4	poly(rC) binding protein 2	Homo sapiens	41-46
24916507-0	2014	Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Kruppel-like factor.	Iron	11-15	placental growth factor	Homo sapiens	26-48
25117470-4	2014	As shown by a comparative two dimensional difference gel electrophoresis (2D-DIGE) approach combined with mass spectrometry, particularly two groups of proteins were affected: the iron-sulfur containing aconitase-type proteins (Aco1p, Lys4p) and the lipoamide-containing subproteome (Lat1p, Kgd2p and Gcv3p).	Iron	180-184	dihydrolipoyllysine-residue acetyltransferase	Saccharomyces cerevisiae S288C	284-289
24916507-1	2014	In adults with sickle cell disease (SCD), markers of iron burden are associated with excessive production of the angiogenic protein placenta growth factor (PlGF) and high estimated pulmonary artery pressure.	Iron	53-57	placental growth factor	Homo sapiens	132-154
24916507-1	2014	In adults with sickle cell disease (SCD), markers of iron burden are associated with excessive production of the angiogenic protein placenta growth factor (PlGF) and high estimated pulmonary artery pressure.	Iron	53-57	placental growth factor	Homo sapiens	156-160
24916507-3	2014	We now demonstrate heme-bound iron (hemin) induces PlGF mRNA &gt;200-fold in a dose- and time-dependent fashion.	Iron	30-34	placental growth factor	Homo sapiens	51-55
24916507-7	2014	SCD patients show higher level expression of both EKLF and PlGF mRNA in circulating blood cells, and markers of iron overload are associated with high PlGF and early mortality.	Iron	112-116	placental growth factor	Homo sapiens	151-155
24916507-8	2014	Finally, PlGF association with iron burden generalizes to other human diseases of iron overload.	Iron	31-35	placental growth factor	Homo sapiens	9-13
24916507-8	2014	Finally, PlGF association with iron burden generalizes to other human diseases of iron overload.	Iron	82-86	placental growth factor	Homo sapiens	9-13
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	219-223	LYR motif containing 4	Homo sapiens	116-121
24890018-6	2014	The anti-TFRC antibody blocked the interaction between transferrin and TFRC and consequently inhibited iron uptake, leading to the iron deprivation-mediated suppression of cell growth and induction of apoptosis.	Iron	103-107	transferrin	Homo sapiens	55-66
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	18-22	LYR motif containing 4	Homo sapiens	116-121
24752844-8	2014	Furthermore, gene expression of different iron regulation-related factors, i.e. pvdS, fur and bqsS, was increased in response to iron limitation.	Iron	42-46	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	80-84
24752844-8	2014	Furthermore, gene expression of different iron regulation-related factors, i.e. pvdS, fur and bqsS, was increased in response to iron limitation.	Iron	129-133	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	80-84
24962641-21	2014	This difference in iron distribution may be associated with the difference in the hepcidin level.	Iron	19-23	hepcidin antimicrobial peptide	Rattus norvegicus	82-90
24890018-6	2014	The anti-TFRC antibody blocked the interaction between transferrin and TFRC and consequently inhibited iron uptake, leading to the iron deprivation-mediated suppression of cell growth and induction of apoptosis.	Iron	131-135	transferrin	Homo sapiens	55-66
24721683-3	2014	NGAL is also an iron trafficking protein, a member of the non-transferrin-bound iron (NTBI) pool and an alternative to the transferrin-mediated iron-delivery pathway.	Iron	80-84	transferrin	Homo sapiens	62-73
24721683-3	2014	NGAL is also an iron trafficking protein, a member of the non-transferrin-bound iron (NTBI) pool and an alternative to the transferrin-mediated iron-delivery pathway.	Iron	80-84	transferrin	Homo sapiens	62-73
24880481-9	2014	RESULTS: In iron deficient patients, iron supplementation led to a marked improvement of iron status (serum iron 5.7+-0.4 to 11.1+-1.1 mumol/L, ferritin 29.3+-6.3 to 145.2+-25.4 mug/L, transferrin saturation 7.5+-0.7 to 19.3+-2.3%, all p&lt;=0.001).	Iron	37-41	transferrin	Homo sapiens	185-196
25338370-0	2014	[Influence of inorganic ions and humic acid on the removal of Pb(II) and Hg(II) in water by zero-valent iron].	Iron	104-108	submaxillary gland androgen regulated protein 3B	Homo sapiens	62-68
25338370-1	2014	The effects of Ca2+, Cl- and humic acid (HA) on the removal rates of Pb(II) and Hg(II) in water by zero-valent (ZVI) and the kinetic characteristics were studied, and the removal mechanism of Pb(II) and Hg(II) by ZVI were preliminarily investigated using X-ray diffraction (XRD).	Iron	112-115	submaxillary gland androgen regulated protein 3B	Homo sapiens	69-75
25338370-1	2014	The effects of Ca2+, Cl- and humic acid (HA) on the removal rates of Pb(II) and Hg(II) in water by zero-valent (ZVI) and the kinetic characteristics were studied, and the removal mechanism of Pb(II) and Hg(II) by ZVI were preliminarily investigated using X-ray diffraction (XRD).	Iron	213-216	submaxillary gland androgen regulated protein 3B	Homo sapiens	69-75
25338370-2	2014	The results indicated that the removal mechanism of Pb(II) might mainly be attributed to the adsorption and co-precipitation of ZVI, while that of Hg(II) might mainly be attributed to the oxidation-reduction of ZVI.	Iron	128-131	submaxillary gland androgen regulated protein 3B	Homo sapiens	52-58
24815210-4	2014	The early pattern of Br in the FE, uniformly expressed except in the polar cells, is established by Notch signaling around stage 6, through the binding of Su(H) to the br early enhancer (brE) region.	Iron	31-33	Notch	Drosophila melanogaster	100-105
24815210-4	2014	The early pattern of Br in the FE, uniformly expressed except in the polar cells, is established by Notch signaling around stage 6, through the binding of Su(H) to the br early enhancer (brE) region.	Iron	31-33	Suppressor of Hairless	Drosophila melanogaster	155-160
25064705-3	2014	The discovery that many of these cases harbor mutations in the TMPRSS6 gene led to the recognition that they represent a single clinical entity: iron-refractory iron deficiency anemia (IRIDA).	Iron	145-149	transmembrane serine protease 6	Homo sapiens	63-70
25064708-4	2014	The authors suggest that extrahepatic iron distribution, and hence toxicity, is influenced by balance between generation of nontransferrin-bound iron from red cell catabolism and the utilization of transferrin iron by the erythron.	Iron	38-42	transferrin	Homo sapiens	127-138
25064708-4	2014	The authors suggest that extrahepatic iron distribution, and hence toxicity, is influenced by balance between generation of nontransferrin-bound iron from red cell catabolism and the utilization of transferrin iron by the erythron.	Iron	145-149	transferrin	Homo sapiens	127-138
25064708-4	2014	The authors suggest that extrahepatic iron distribution, and hence toxicity, is influenced by balance between generation of nontransferrin-bound iron from red cell catabolism and the utilization of transferrin iron by the erythron.	Iron	145-149	transferrin	Homo sapiens	127-138
24766461-6	2014	We found lower blood catalase and glutathione peroxidase activity to be correlated with lower iron and selenium respectively.	Iron	94-98	catalase	Canis lupus familiaris	21-29
24880481-9	2014	RESULTS: In iron deficient patients, iron supplementation led to a marked improvement of iron status (serum iron 5.7+-0.4 to 11.1+-1.1 mumol/L, ferritin 29.3+-6.3 to 145.2+-25.4 mug/L, transferrin saturation 7.5+-0.7 to 19.3+-2.3%, all p&lt;=0.001).	Iron	37-41	transferrin	Homo sapiens	185-196
24567067-1	2014	The essential role of transferrin in mammalian iron metabolism is firmly established.	Iron	47-51	transferrin	Homo sapiens	22-33
24837286-2	2014	The neisserial transferrin binding proteins (Tbps) comprise a bipartite system for iron acquisition from human transferrin.	Iron	83-87	transferrin	Homo sapiens	15-26
24753220-0	2014	Iron-induced oxidative rat liver injury after non-heart-beating warm ischemia is mediated by tumor necrosis factor alpha and prevented by deferoxamine.	Iron	0-4	tumor necrosis factor	Rattus norvegicus	93-120
24837286-2	2014	The neisserial transferrin binding proteins (Tbps) comprise a bipartite system for iron acquisition from human transferrin.	Iron	83-87	transferrin	Homo sapiens	111-122
23914925-5	2014	Our results were compatible with experimental published data, showing feasible cation-pi interaction between the iron atom of the heme group of TXAS and the basic nitrogen atom of the imidazolyl group of those inhibitors.	Iron	113-117	thromboxane A synthase 1	Homo sapiens	144-148
24998390-4	2014	Exposure to iron chelators led to repression of mTOR signaling as evidenced by decreased phosphorylation of its target p70S6 kinase.	Iron	12-16	mechanistic target of rapamycin kinase	Homo sapiens	48-52
24901380-5	2014	We found higher copper and lower iron content in the liver of Npc1(-/-) mice of different ages, compared to controls; these changes in copper and iron content were correlated with increased ceruloplasmin, metallothionein 1, and transferrin receptor gene expression and decreased gene expression of Commd1, ferritin-light chain and ferroportin in the liver of Npc1(-/-) mice of different ages.	Iron	33-37	NPC intracellular cholesterol transporter 1	Mus musculus	62-66
24901380-9	2014	Our results confirm that the NPC1 protein is required for copper and iron homeostasis.	Iron	69-73	NPC intracellular cholesterol transporter 1	Mus musculus	29-33
26031015-12	2014	The obtained results revealed that, iron overload (IOL) resulted in significant increase in serum iron, TIBC, Tf, TS% and ferritin levels and AST and ALT activities and also increased liver iron, L-MDA and NO levels.	Iron	36-40	transferrin	Rattus norvegicus	110-112
24906241-2	2014	PATIENTS AND METHODS: The study included 33 outpatients (23 males average age 50.6 years and 10 females average age 60.6 years) with a disorder of iron metabolism (transferrin saturation &gt; 75 %) as confirmation of hemochromatosis who were subjected to molecular genetic and clinical analyses.	Iron	147-151	transferrin	Homo sapiens	164-175
25379371-0	2014	Relationship between Serum Levels of Body Iron Parameters and Insulin Resistance and Metabolic Syndrome in Korean Children.	Iron	42-46	insulin	Homo sapiens	62-69
25379371-2	2014	We evaluated the relationship between body iron status indicators, including ferritin and sTfR, and insulin resistance and metabolic syndrome (MetS) in Korean children.	Iron	43-47	insulin	Homo sapiens	100-107
26031015-12	2014	The obtained results revealed that, iron overload (IOL) resulted in significant increase in serum iron, TIBC, Tf, TS% and ferritin levels and AST and ALT activities and also increased liver iron, L-MDA and NO levels.	Iron	36-40	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	142-145
25379371-8	2014	Children in the highest tertile for homeostasis model assessment-insulin resistance (HOMA-IR) had higher TIBC (p = 0.0005) and lower serum iron (p = 0.0341), and the lowest TS (p &lt; 0.0001) after adjustment for confounders.	Iron	139-143	insulin	Homo sapiens	65-72
25379371-10	2014	CONCLUSION: The associations of serum levels of iron metabolism markers with leptin levels, HOMA-IR, and MetS suggest that iron-related factors may involve insulin resistance and MetS.	Iron	48-52	insulin	Homo sapiens	156-163
26031015-14	2014	Rutin administration to iron-overloaded rats resulted in significant decrease in serum total iron, TIBC, Tf, TS%, ferritin levels and AST and ALT activities and liver total iron, L-MDA and NO levels with significant increases in serum UIBC, albumin, total protein and total cholesterol levels and in liver GSH, CAT and SOD activities compared with the IOL group.	Iron	24-28	transferrin	Rattus norvegicus	105-107
25379371-10	2014	CONCLUSION: The associations of serum levels of iron metabolism markers with leptin levels, HOMA-IR, and MetS suggest that iron-related factors may involve insulin resistance and MetS.	Iron	123-127	insulin	Homo sapiens	156-163
26031015-14	2014	Rutin administration to iron-overloaded rats resulted in significant decrease in serum total iron, TIBC, Tf, TS%, ferritin levels and AST and ALT activities and liver total iron, L-MDA and NO levels with significant increases in serum UIBC, albumin, total protein and total cholesterol levels and in liver GSH, CAT and SOD activities compared with the IOL group.	Iron	24-28	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	134-137
25252070-1	2014	Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive disease characterized by congenital hypochromic microcytic anemia, low transferrin saturation, low serum iron, normal-high serum ferritin, and increased hepcidin.	Iron	0-4	transferrin	Homo sapiens	148-159
25252070-1	2014	Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive disease characterized by congenital hypochromic microcytic anemia, low transferrin saturation, low serum iron, normal-high serum ferritin, and increased hepcidin.	Iron	16-20	transferrin	Homo sapiens	148-159
25130822-0	2014	[Iron chelation therapy and its influence on the alleviation of EPO resistance in MDS patients].	Iron	1-5	erythropoietin	Homo sapiens	64-67
24603312-6	2014	Oxidative stress (H2O2 production) appeared related to SiC particle size, while iron level regulated pro-inflammatory response (TNFalpha production).	Iron	80-84	tumor necrosis factor	Homo sapiens	128-136
24599805-1	2014	BACKGROUND: The transferrin saturation (TSAT) ratio is a commonly used indicator of iron deficiency and iron overload in clinical practice but precise relationships with total and cardiovascular mortality are unclear.	Iron	84-88	transferrin	Homo sapiens	16-27
25044383-2	2014	Patients with inflammation respond less well to treatment with erythropoietin, possibly because the increased production of hepcidin reduces the availability of iron for hematopoiesis.	Iron	161-165	erythropoietin	Homo sapiens	63-77
25130822-5	2014	Besides, the difference in the incidence of EPO resistance in iron overload group and non-iron overload group was assessed before and after therapy, and 58 cases of low-risk and EPO&lt;1 000 U/L MDS patients were given rEPO therapy.	Iron	62-66	erythropoietin	Homo sapiens	44-47
25130822-6	2014	The results showed that the level of EPO in non-iron overload group was higher than that in the normal control group (997.44 +- 473.48 vs 467.27 +- 238.49, P &lt; 0.05).	Iron	48-52	erythropoietin	Homo sapiens	37-40
25130822-7	2014	Obviously, the level of EPO in iron overload group was higher than that in non-iron overload group and control group (3257.59 +- 697.19 vs 997.44 +- 473.48, P = 0.012, 3257.59 +- 697.19 vs 467.27 +- 238.49, P = 0.002).	Iron	31-35	erythropoietin	Homo sapiens	24-27
25130822-7	2014	Obviously, the level of EPO in iron overload group was higher than that in non-iron overload group and control group (3257.59 +- 697.19 vs 997.44 +- 473.48, P = 0.012, 3257.59 +- 697.19 vs 467.27 +- 238.49, P = 0.002).	Iron	79-83	erythropoietin	Homo sapiens	24-27
25130822-8	2014	Otherwise, the incidence of EPO resistance in iron overload group was higher than that in non-iron overload group (18/35 vs 2/23, P = 0.001), and the level of EPO and SF was positively related to each other in iron overload group (r = 0.310,P = 0.036).	Iron	46-50	erythropoietin	Homo sapiens	28-31
25130822-8	2014	Otherwise, the incidence of EPO resistance in iron overload group was higher than that in non-iron overload group (18/35 vs 2/23, P = 0.001), and the level of EPO and SF was positively related to each other in iron overload group (r = 0.310,P = 0.036).	Iron	46-50	erythropoietin	Homo sapiens	159-162
25130822-8	2014	Otherwise, the incidence of EPO resistance in iron overload group was higher than that in non-iron overload group (18/35 vs 2/23, P = 0.001), and the level of EPO and SF was positively related to each other in iron overload group (r = 0.310,P = 0.036).	Iron	94-98	erythropoietin	Homo sapiens	159-162
25130822-8	2014	Otherwise, the incidence of EPO resistance in iron overload group was higher than that in non-iron overload group (18/35 vs 2/23, P = 0.001), and the level of EPO and SF was positively related to each other in iron overload group (r = 0.310,P = 0.036).	Iron	94-98	erythropoietin	Homo sapiens	159-162
25130822-1	2014	This study was aimed to investigate the changes of erythropoietin (EPO), hemoglobin(Hb) and recombinant EPO (rEPO) levels in MDS patients receiving iron chelation therapy, and to explore the relationship between EPO and serum ferritin(SF).	Iron	148-152	erythropoietin	Homo sapiens	104-107
25130822-11	2014	It is concluded that iron chelation therapy can improve the efficacy of EPO to alleviate EPO resistance in patients wtih anemic MDS, decrease the pathological level of EPO, enhance Hb levels and reduce the dependency on blood transfusion.	Iron	21-25	erythropoietin	Homo sapiens	72-75
25130822-11	2014	It is concluded that iron chelation therapy can improve the efficacy of EPO to alleviate EPO resistance in patients wtih anemic MDS, decrease the pathological level of EPO, enhance Hb levels and reduce the dependency on blood transfusion.	Iron	21-25	erythropoietin	Homo sapiens	89-92
25130822-11	2014	It is concluded that iron chelation therapy can improve the efficacy of EPO to alleviate EPO resistance in patients wtih anemic MDS, decrease the pathological level of EPO, enhance Hb levels and reduce the dependency on blood transfusion.	Iron	21-25	erythropoietin	Homo sapiens	89-92
25130822-1	2014	This study was aimed to investigate the changes of erythropoietin (EPO), hemoglobin(Hb) and recombinant EPO (rEPO) levels in MDS patients receiving iron chelation therapy, and to explore the relationship between EPO and serum ferritin(SF).	Iron	148-152	erythropoietin	Homo sapiens	104-107
24878983-0	2014	Nanocasted synthesis of ordered mesoporous cerium iron mixed oxide and its excellent performances for As(V) and Cr(VI) removal from aqueous solutions.	Iron	50-54	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	102-107
24878983-3	2014	A mechanism study showed that both Fe and Ce compositions participated in the As(V) or Cr(VI) adsorption process, and complex interactions were involved, including electrostatic attraction and the replacement of hydroxyl groups to form anionic negatively charged inner-sphere surface complexes.	Iron	35-37	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	78-83
25100994-9	2014	In mutant SOD-1 mouse models, increased Fe is also detected in the spinal cord and treatment with Fe-chelating drugs lowers spinal cord Fe, preserves motor neurons, and extends lifespan.	Iron	40-42	superoxide dismutase 1, soluble	Mus musculus	10-15
25117307-9	2014	IRP2 can regulate the expression of TfR and Fn by changing its own protein expression and thereby regulate iron metabolism.	Iron	107-111	iron responsive element binding protein 2	Homo sapiens	0-4
24964018-3	2014	We present mutagenesis, optical, and nuclear magnetic resonance data for the recombinant protein and show that at pH near neutral in the absence of added ligand, THB1 coordinates the heme iron with the canonical proximal histidine and a distal lysine.	Iron	188-192	uncharacterized protein	Chlamydomonas reinhardtii	162-166
25100994-9	2014	In mutant SOD-1 mouse models, increased Fe is also detected in the spinal cord and treatment with Fe-chelating drugs lowers spinal cord Fe, preserves motor neurons, and extends lifespan.	Iron	98-100	superoxide dismutase 1, soluble	Mus musculus	10-15
25100994-9	2014	In mutant SOD-1 mouse models, increased Fe is also detected in the spinal cord and treatment with Fe-chelating drugs lowers spinal cord Fe, preserves motor neurons, and extends lifespan.	Iron	98-100	superoxide dismutase 1, soluble	Mus musculus	10-15
25038614-9	2014	Bivariate regression analysis between baseline platelet count and transferrin saturation by iron (TSAT) showed a negative association (betaTSAT = -5.82, P = .0007) and moderate correlation (R = 0.32).	Iron	92-96	transferrin	Homo sapiens	66-77
25044349-0	2014	The scaffold protein IscU retains a structured conformation in the Fe-S cluster assembly complex.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	21-25
25044349-1	2014	IscU and IscS are two essential proteins in the machine responsible for the biogenesis of iron-sulfur clusters, prosthetic groups that are involved in several essential functions.	Iron	90-94	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
24979669-2	2014	Insertion of CS2 into the polar Cu-Fe bond of (IMes)Cu-FeCp(CO)2 proceeds at mild conditions and results in the simultaneous presence of two unprecedented CS2 binding modes (mu3:eta(4) and mu3:eta(3)) in the same product.	Iron	35-37	chorionic somatomammotropin hormone 2	Homo sapiens	13-16
24979669-2	2014	Insertion of CS2 into the polar Cu-Fe bond of (IMes)Cu-FeCp(CO)2 proceeds at mild conditions and results in the simultaneous presence of two unprecedented CS2 binding modes (mu3:eta(4) and mu3:eta(3)) in the same product.	Iron	35-37	chorionic somatomammotropin hormone 2	Homo sapiens	155-158
25076907-5	2014	Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages.	Iron	10-14	interferon gamma	Homo sapiens	116-132
25076907-5	2014	Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages.	Iron	10-14	interferon gamma	Homo sapiens	134-143
25076907-5	2014	Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages.	Iron	10-14	erythropoietin	Homo sapiens	181-195
24556216-0	2014	Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.	Iron	34-38	proprotein convertase subtilisin/kexin type 7	Homo sapiens	91-96
24556216-5	2014	Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.	Iron	29-33	transmembrane serine protease 6	Homo sapiens	50-57
24556216-5	2014	Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.	Iron	29-33	proprotein convertase subtilisin/kexin type 7	Homo sapiens	59-64
25076907-5	2014	Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages.	Iron	155-159	erythropoietin	Homo sapiens	55-69
25076907-5	2014	Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages.	Iron	155-159	interferon gamma	Homo sapiens	116-132
25076907-5	2014	Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages.	Iron	155-159	interferon gamma	Homo sapiens	134-143
24780244-4	2014	The rate of Cygb(Fe(3+)) reduction increased ~6% per  C when temperature varied from 35 C to 40 C. The yield and the rate of Cygb(Fe(3+)) reduction significantly increases with pH (2-3 times per pH unit), paralleling the formation of the Asc ion (A(2-)) and the increased stability of reduced state of heme iron at high pH values.	Iron	307-311	cytoglobin	Homo sapiens	12-16
25076907-6	2014	Thus, macrophages loaded with iron lose their ability to kill intracellular pathogens via IFN-gamma mediated effector pathways such as nitric oxide (NO) formation.	Iron	30-34	interferon gamma	Homo sapiens	90-99
24780244-4	2014	The rate of Cygb(Fe(3+)) reduction increased ~6% per  C when temperature varied from 35 C to 40 C. The yield and the rate of Cygb(Fe(3+)) reduction significantly increases with pH (2-3 times per pH unit), paralleling the formation of the Asc ion (A(2-)) and the increased stability of reduced state of heme iron at high pH values.	Iron	307-311	cytoglobin	Homo sapiens	125-129
25076907-8	2014	In addition, certain innate resistance genes such as natural resistance associated macrophage protein function (Nramp1) or lipocalin-2 exert part of their antimicrobial activity by controlling host and/or microbial iron homeostasis.	Iron	215-219	solute carrier family 11 member 1	Homo sapiens	112-118
24828458-4	2014	A type of iron/sulfur/-nitrosyl cluster, Roussin"s black salt anion Fe4S3(NO)7(-) (RBS) was conjugated with the Ag2S QDs@CS to obtain Ag2S QDs@CS-RBS nanospheres.	Iron	10-14	angiotensin II receptor, type 1a	Mus musculus	112-116
24863789-0	2014	Nanoscale Zero-Valent Iron (NZVI) supported on sineguelas waste for Pb(II) removal from aqueous solution: kinetics, thermodynamic and mechanism.	Iron	22-26	submaxillary gland androgen regulated protein 3B	Homo sapiens	68-74
24863789-1	2014	In this study, the synthesis and characterization of a new adsorbent containing nanoscale zerovalent iron particles (NZVI) decorated sineguelas waste (S-NaOH-NZVI) from agriculture biomass was investigated for the adsorption/reduction of inorganic pollution such as Pb(II) ions.	Iron	101-105	submaxillary gland androgen regulated protein 3B	Homo sapiens	266-272
24867957-1	2014	Matriptase-2 is a hepatic membrane serine protease that regulates iron homeostasis.	Iron	66-70	transmembrane serine protease 6	Homo sapiens	0-12
24446527-0	2014	Transferrin iron starvation therapy for lethal bacterial and fungal infections.	Iron	12-16	transferrin	Homo sapiens	0-11
24446527-4	2014	Human transferrin inhibited growth of gram-positive (Staphylococcus aureus), gram-negative (Acinetobacter baumannii), and fungal (Candida albicans) pathogens by sequestering iron and disrupting membrane potential.	Iron	174-178	transferrin	Homo sapiens	6-17
24828458-4	2014	A type of iron/sulfur/-nitrosyl cluster, Roussin"s black salt anion Fe4S3(NO)7(-) (RBS) was conjugated with the Ag2S QDs@CS to obtain Ag2S QDs@CS-RBS nanospheres.	Iron	10-14	angiotensin II receptor, type 1a	Mus musculus	134-138
24991925-7	2014	Apo-transferrin (Tf), the primary carrier of soluble iron in the plasma, binds ferric ion to form mono-ferric and di-ferric transferrin.	Iron	53-57	transferrin	Homo sapiens	4-15
24991925-7	2014	Apo-transferrin (Tf), the primary carrier of soluble iron in the plasma, binds ferric ion to form mono-ferric and di-ferric transferrin.	Iron	53-57	transferrin	Homo sapiens	124-135
24988074-11	2014	The H63D genotype modified the association between the lead and iron metabolism such that increased blood lead is associated with a higher body iron content or a lower transferrin in the H63D variant.	Iron	64-68	transferrin	Homo sapiens	168-179
24599423-10	2014	In conclusion, local iron retention and altered iron recycling associated to high hepcidin and low transferrin systemic concentrations could lead to reduced circulating haemoglobin levels in AAA patients.	Iron	21-25	transferrin	Homo sapiens	99-110
24599423-10	2014	In conclusion, local iron retention and altered iron recycling associated to high hepcidin and low transferrin systemic concentrations could lead to reduced circulating haemoglobin levels in AAA patients.	Iron	48-52	transferrin	Homo sapiens	99-110
24652616-5	2014	Cardiac iron was assessed as cT2*.	Iron	8-12	solute carrier family 6 member 10, pseudogene	Homo sapiens	29-32
24582833-5	2014	Using an Fe EDTA conjugate of PA1, 19 affinity cleavage (AC) patterns were detected for this fragment.	Iron	9-11	PAXIP1 associated glutamate rich protein 1	Homo sapiens	30-33
24716439-3	2014	In order to understand the structural alterations that impair its function, Tf was glycated in vitro and the modification sites were determined by MS. Iron binding to glycated Tf was assessed and a computational approach was conducted to study how glycation influences the iron-binding capacity of this protein.	Iron	151-155	transferrin	Homo sapiens	176-178
24716439-4	2014	Glycated Tf samples were found to bind iron less avidly than non-modified Tf and MS results revealed 12 glycation sites, allowing the establishment of Lys534 and Lys206 as the most vulnerable residues to this modification.	Iron	39-43	transferrin	Homo sapiens	9-11
24716439-8	2014	Molecular dynamics simulations also suggested that additional loss of iron binding capacity may result from the stereochemical effects induced by the glycation of lysine residues that prevent the conformational changes (from open to closed Tf forms) required for metal binding.	Iron	70-74	transferrin	Homo sapiens	240-242
24750026-0	2014	MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice.	Iron	15-19	methyl-CpG binding domain protein 5	Mus musculus	0-4
24704458-6	2014	Since Cyp7a1 has a heme iron at the active site, AA must function as a reductant of the iron required for the continuous activation of Cyp7a1.	Iron	24-28	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	6-12
24704458-6	2014	Since Cyp7a1 has a heme iron at the active site, AA must function as a reductant of the iron required for the continuous activation of Cyp7a1.	Iron	88-92	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	6-12
24704458-6	2014	Since Cyp7a1 has a heme iron at the active site, AA must function as a reductant of the iron required for the continuous activation of Cyp7a1.	Iron	88-92	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	135-141
24522175-0	2014	Ophthalmic features of PLA2G6-related paediatric  neurodegeneration with brain iron accumulation.	Iron	79-83	phospholipase A2 group VI	Homo sapiens	23-29
24750026-4	2014	Here, we show that global deletion of Mbd5 in mice induces an iron overload phenotype.	Iron	62-66	methyl-CpG binding domain protein 5	Mus musculus	38-42
24750026-5	2014	Liver and serum iron levels in Mbd5(-/-) mice were 3 2-fold and 1 5-fold higher respectively, than wild-type littermates; moreover, serum ferritin was increased &gt;5-fold in the Mbd5(-/-) mice.	Iron	16-20	methyl-CpG binding domain protein 5	Mus musculus	31-35
24281368-3	2014	Analysis of enzyme activities of the five respiratory chain complexes in our patients" skeletal muscle showed severely impaired activities of iron sulfur (Fe-S)-dependent complexes I, II and III and mitochondrial aconitase.	Iron	155-159	aconitase 2	Homo sapiens	199-222
24281368-6	2014	Fdx2 is the second component of the Fe-S cluster biogenesis machinery, the first being IscU that is associated with isolated mitochondrial myopathy.	Iron	36-40	iron-sulfur cluster assembly enzyme	Homo sapiens	87-91
27774468-11	2014	Some are close to the hypoxia-inducible transcription factor alpha/2-oxoglutarate or the iron binding sites for PHD2.	Iron	89-93	egl-9 family hypoxia inducible factor 1	Homo sapiens	112-116
24269922-2	2014	The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1beta.	Iron	4-8	interleukin 6	Homo sapiens	72-90
24269922-2	2014	The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1beta.	Iron	4-8	interleukin 1 beta	Homo sapiens	95-102
24487782-4	2014	WABS is genetically linked to bi-allelic mutations in the ChlR1/DDX11 gene which encodes a protein of the conserved family of Iron-Sulfur (Fe-S) cluster DNA helicases.	Iron	139-143	DEAD/H-box helicase 11	Homo sapiens	58-63
24487782-4	2014	WABS is genetically linked to bi-allelic mutations in the ChlR1/DDX11 gene which encodes a protein of the conserved family of Iron-Sulfur (Fe-S) cluster DNA helicases.	Iron	139-143	DEAD/H-box helicase 11	Homo sapiens	64-69
24969192-0	2014	Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload.	Iron	94-98	insulin	Homo sapiens	34-41
24807908-4	2014	Unique among the Shc family, transcription of p66Shc is activated through the antioxidant response element (ARE)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in K562 human erythroleukemia and other cell types after treatment with hemin, an iron-containing porphyrin.	Iron	254-258	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
25150122-0	2014	Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats.	Iron	8-12	hepcidin antimicrobial peptide	Rattus norvegicus	73-81
24969192-9	2014	Iron overload increases insulin resistance and cardiovascular risk in hemodialysis subjects.	Iron	0-4	insulin	Homo sapiens	24-31
24705244-1	2014	Human serum transferrin (hTf) is a single-chain bilobal glycoprotein that efficiently delivers iron to mammalian cells by endocytosis via the transferrin/transferrin receptor system.	Iron	95-99	transferrin	Homo sapiens	12-23
24705244-1	2014	Human serum transferrin (hTf) is a single-chain bilobal glycoprotein that efficiently delivers iron to mammalian cells by endocytosis via the transferrin/transferrin receptor system.	Iron	95-99	transferrin	Homo sapiens	142-153
24705244-1	2014	Human serum transferrin (hTf) is a single-chain bilobal glycoprotein that efficiently delivers iron to mammalian cells by endocytosis via the transferrin/transferrin receptor system.	Iron	95-99	transferrin	Homo sapiens	142-153
24705244-8	2014	Our results are discussed in terms of a plausible scenario for iron dissociation from transferrin by which the highly stable Fe(3+)-hTf complex might be reduced to the more labile Fe(2+) ion before iron is released to the cytosol.	Iron	63-67	transferrin	Homo sapiens	86-97
24705244-8	2014	Our results are discussed in terms of a plausible scenario for iron dissociation from transferrin by which the highly stable Fe(3+)-hTf complex might be reduced to the more labile Fe(2+) ion before iron is released to the cytosol.	Iron	198-202	transferrin	Homo sapiens	86-97
24740789-8	2014	The iron staining in the spleen in the BNx group was significantly more intense than that in the BNx-Sham group; however, after an HD session, splenic iron staining diminished to the level of the sham group along with an increase in plasma iron and a decrease in hepcidin.	Iron	4-8	hepcidin antimicrobial peptide	Rattus norvegicus	263-271
24978810-6	2014	Patients with absolute iron deficiency (transferrin saturation (TSAT) &lt;20% and ferritin &lt;40 ng/mL) had the lowest hepcidin levels (5.0 ng/mL [0.7-11.7]), and those with a normal iron profile (TSAT &gt;=20% and ferritin &gt;=40), the highest (34.5 ng/mL [23.7-51.6]).	Iron	23-27	transferrin	Homo sapiens	40-51
24792994-1	2014	A new PC(sp(3))P ligand N,N"-bis(diphenylphosphino)dipyrromethane [PCH2P] (1) was prepared and its iron, cobalt and nickel chemistry was explored.	Iron	99-103	Sp3 transcription factor pseudogene	Homo sapiens	6-16
24740789-9	2014	BNx moved iron from hemoglobin and the plasma to the spleen, which is associated with an increase in plasma hepcidin.	Iron	10-14	hepcidin antimicrobial peptide	Rattus norvegicus	108-116
24740789-10	2014	A single HD session accelerated the release of iron from the spleen, and the increased plasma iron was linked to the removal of hepcidin.	Iron	94-98	hepcidin antimicrobial peptide	Rattus norvegicus	128-136
24666342-0	2014	Effect of maternal iron status on the number of CD34+ stem cells harvested from umbilical cord blood.	Iron	19-23	CD34 molecule	Homo sapiens	48-52
24666342-3	2014	This study investigated the impact of selected maternal indices (in particular iron status) on the number of CD34+ cells collected in the UCB.	Iron	79-83	CD34 molecule	Homo sapiens	109-113
24666342-9	2014	This finding suggests that maternal SF and associated iron status play a significant, but as yet undefined, role in the generation of CD34+ cells in UCB.	Iron	54-58	CD34 molecule	Homo sapiens	134-138
24875119-3	2014	Together with the recent determination of an iron(IV)hydroxide pK(a) ~ 12 in the thiolate-ligated heme enzyme cytochrome P450, this result provides insight into Nature"s ability to tune catalytic function through its choice of axial ligand.	Iron	45-49	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	110-125
24792994-0	2014	A new PC(sp(3))P ligand and its coordination chemistry with low-valent iron, cobalt and nickel complexes.	Iron	71-75	Sp3 transcription factor pseudogene	Homo sapiens	6-16
24740789-11	2014	Our data suggested that hepcidin might dynamically modulate the iron metabolism in BNx as well as in HD.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	24-32
24927015-10	2014	Serum iron and ferritin levels in HCV-monoinfected patients were positively correlated with serum ALT/AST.	Iron	6-10	solute carrier family 17 member 5	Homo sapiens	102-105
24632099-2	2014	This assay accurately measures between 1 and 200 muM sample iron concentrations within 21/2 hours.	Iron	60-64	latexin	Homo sapiens	49-52
24971061-4	2014	Furthermore, these metals (such as zinc, copper and iron) play roles in the regulation of the levels of AD-related proteins, including the amyloid precursor protein (APP) and tau.	Iron	52-56	amyloid beta precursor protein	Homo sapiens	139-164
30363981-1	2014	A link between restless legs syndrome (RLS) and iron has been recognized for several decades.	Iron	48-52	RLS1	Homo sapiens	39-42
30363981-2	2014	Yet, the precise role that iron or other components of iron metabolism play in bringing about RLS is still a matter of debate.	Iron	27-31	RLS1	Homo sapiens	94-97
30363981-2	2014	Yet, the precise role that iron or other components of iron metabolism play in bringing about RLS is still a matter of debate.	Iron	55-59	RLS1	Homo sapiens	94-97
30363981-5	2014	To provide a better understanding of the complex interplay between iron metabolism and RLS and highlight areas that need further elucidation, we systematically and critically review the current literature on the role of iron in RLS pathophysiology and treatment with a special emphasis on genetics, neuropathology, cell and animal models, imaging studies, and therapy.	Iron	220-224	RLS1	Homo sapiens	228-231
24778179-0	2014	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	Iron	18-22	F-box and leucine rich repeat protein 5	Homo sapiens	33-38
24778179-2	2014	IRP2 plays a central role in the maintenance of cellular iron homeostasis in mammals through posttranscriptional regulation of proteins that contribute to control of the intracellular iron concentration.	Iron	57-61	iron responsive element binding protein 2	Homo sapiens	0-4
24778179-2	2014	IRP2 plays a central role in the maintenance of cellular iron homeostasis in mammals through posttranscriptional regulation of proteins that contribute to control of the intracellular iron concentration.	Iron	184-188	iron responsive element binding protein 2	Homo sapiens	0-4
24778179-8	2014	Such accumulation of FBXL5 in turn led to a decrease in the intracellular content of ferrous iron.	Iron	85-97	F-box and leucine rich repeat protein 5	Homo sapiens	21-26
24843120-2	2014	Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center.	Iron	89-93	poly(rC) binding protein 1	Homo sapiens	26-31
24843120-2	2014	Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center.	Iron	89-93	poly(rC) binding protein 2	Homo sapiens	36-41
24843120-2	2014	Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center.	Iron	202-206	poly(rC) binding protein 1	Homo sapiens	26-31
24843120-2	2014	Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center.	Iron	202-206	poly(rC) binding protein 2	Homo sapiens	36-41
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	48-52	poly(rC) binding protein 1	Homo sapiens	19-24
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	48-52	poly(rC) binding protein 2	Homo sapiens	29-34
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	104-108	poly(rC) binding protein 1	Homo sapiens	19-24
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	104-108	poly(rC) binding protein 2	Homo sapiens	29-34
24843120-4	2014	Cells depleted of PCBP1 or PCBP2 exhibited loss of DOHH activity and loss of the holo form of the enzyme in cells, particularly when cells were made mildly iron-deficient.	Iron	156-160	poly(rC) binding protein 1	Homo sapiens	18-23
24843120-4	2014	Cells depleted of PCBP1 or PCBP2 exhibited loss of DOHH activity and loss of the holo form of the enzyme in cells, particularly when cells were made mildly iron-deficient.	Iron	156-160	poly(rC) binding protein 2	Homo sapiens	27-32
24843120-6	2014	PCBP1 bound to DOHH in iron-treated cells but not in control or iron-deficient cells.	Iron	23-27	poly(rC) binding protein 1	Homo sapiens	0-5
24843120-10	2014	Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.	Iron	35-39	poly(rC) binding protein 1	Homo sapiens	6-11
24843120-10	2014	Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.	Iron	35-39	poly(rC) binding protein 2	Homo sapiens	16-21
24843120-10	2014	Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.	Iron	92-96	poly(rC) binding protein 1	Homo sapiens	6-11
24843120-10	2014	Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.	Iron	92-96	poly(rC) binding protein 2	Homo sapiens	16-21
24843120-10	2014	Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.	Iron	92-96	poly(rC) binding protein 1	Homo sapiens	6-11
24843120-10	2014	Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.	Iron	92-96	poly(rC) binding protein 2	Homo sapiens	16-21
24667910-1	2014	Thrombin and iron are two major players in intracerebral hemorrhage-induced brain injury and our recent study found that thrombin contributes to hydrocephalus development in a rat model of intraventricular hemorrhage (IVH).	Iron	13-17	coagulation factor II	Rattus norvegicus	121-129
24418516-0	2014	Iron uptake and transfer from ceruloplasmin to transferrin.	Iron	0-4	transferrin	Homo sapiens	47-58
24418516-16	2014	GENERAL SIGNIFICANCE: Ceruloplasmin is a go-between dietary or recycled Fe(2+) and transferrin transported Fe(3+).	Iron	107-109	transferrin	Homo sapiens	83-94
24345904-5	2014	In rats fed R-type of diets after stage II hepatic superoxide dismutase (SOD) and catalase (CAT) activity, but not glutathione peroxidation activity and total antioxidant capacity, was lower in iron and iron/zinc supplemented than in non-supplemented rats, whereas after stage III in iron/zinc supplemented SOD was lower and CAT activity was higher in comparison with non-supplemented and iron supplemented rats.	Iron	194-198	catalase	Rattus norvegicus	82-90
25158492-7	2014	Sequential fractionation indicated that the NH4Cl-P decreased, but the Fe/Al-P, HCl-P and Res-P increased.	Iron	71-73	alkaline phosphatase, placental	Homo sapiens	74-78
25158492-9	2014	The incorporated Fe/Al-P accounts for 37.49% (100 r x min(-1)), 42.32% (200 r x min(-1)) and 54.24% (300 r x min(-1)) of non-occluded Fe/Al-P in the sediments respectively, indicating that the percentage of incorporated P to occluded Fe/Al-P decreases with the increase of disturbance intensity.	Iron	17-19	alkaline phosphatase, placental	Homo sapiens	20-24
25158492-9	2014	The incorporated Fe/Al-P accounts for 37.49% (100 r x min(-1)), 42.32% (200 r x min(-1)) and 54.24% (300 r x min(-1)) of non-occluded Fe/Al-P in the sediments respectively, indicating that the percentage of incorporated P to occluded Fe/Al-P decreases with the increase of disturbance intensity.	Iron	17-19	alkaline phosphatase, placental	Homo sapiens	137-141
25158492-9	2014	The incorporated Fe/Al-P accounts for 37.49% (100 r x min(-1)), 42.32% (200 r x min(-1)) and 54.24% (300 r x min(-1)) of non-occluded Fe/Al-P in the sediments respectively, indicating that the percentage of incorporated P to occluded Fe/Al-P decreases with the increase of disturbance intensity.	Iron	17-19	alkaline phosphatase, placental	Homo sapiens	137-141
25158492-9	2014	The incorporated Fe/Al-P accounts for 37.49% (100 r x min(-1)), 42.32% (200 r x min(-1)) and 54.24% (300 r x min(-1)) of non-occluded Fe/Al-P in the sediments respectively, indicating that the percentage of incorporated P to occluded Fe/Al-P decreases with the increase of disturbance intensity.	Iron	134-136	alkaline phosphatase, placental	Homo sapiens	20-24
25158492-9	2014	The incorporated Fe/Al-P accounts for 37.49% (100 r x min(-1)), 42.32% (200 r x min(-1)) and 54.24% (300 r x min(-1)) of non-occluded Fe/Al-P in the sediments respectively, indicating that the percentage of incorporated P to occluded Fe/Al-P decreases with the increase of disturbance intensity.	Iron	134-136	alkaline phosphatase, placental	Homo sapiens	20-24
25158492-10	2014	The variation of HCl-P under the same disturbance intensity is the same as the occluded Fe/Al-P.	Iron	88-90	alkaline phosphatase, placental	Homo sapiens	91-95
24786977-0	2014	Angiotensin II inhibits uptake of transferrin-bound iron but not non-transferrin-bound iron by cultured astrocytes.	Iron	52-56	angiotensinogen	Homo sapiens	0-14
24170452-3	2014	FES uptake was evaluated qualitatively and quantitatively, and associated with response and with ER expression.	Iron	0-3	estrogen receptor 1	Homo sapiens	97-99
24170452-7	2014	All patients with an ER-negative biopsy had both low uptake and at least one site of FES-negative disease.	Iron	85-88	estrogen receptor 1	Homo sapiens	21-23
24170452-9	2014	CONCLUSIONS: Low/absent FES uptake correlates with lack of ER expression.	Iron	24-27	estrogen receptor 1	Homo sapiens	59-61
24170452-10	2014	FES-positron emission tomography can help identify patients with endocrine resistant disease and safely measures ER in MBC.	Iron	0-3	estrogen receptor 1	Homo sapiens	113-115
24786977-0	2014	Angiotensin II inhibits uptake of transferrin-bound iron but not non-transferrin-bound iron by cultured astrocytes.	Iron	52-56	transferrin	Homo sapiens	34-45
24786977-3	2014	We demonstrated that ANGII could significantly inhibit transferrin-bound iron (Tf-Fe) uptake and iron release as well as the expression of transferrin receptor 1 (TfR1) and the iron exporter ferroportin 1 (Fpn1) in cultured astrocytes.	Iron	97-101	angiotensinogen	Homo sapiens	21-26
24786977-1	2014	The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain.	Iron	78-82	angiotensinogen	Homo sapiens	210-215
24786977-4	2014	This indicated that the inhibitory role of ANGII on Tf-Fe uptake and iron release is mediated by its negative effect on the expression of TfR1 and Fpn1.	Iron	55-57	angiotensinogen	Homo sapiens	43-48
24786977-4	2014	This indicated that the inhibitory role of ANGII on Tf-Fe uptake and iron release is mediated by its negative effect on the expression of TfR1 and Fpn1.	Iron	69-73	angiotensinogen	Homo sapiens	43-48
24786977-1	2014	The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain.	Iron	183-187	angiotensinogen	Homo sapiens	146-160
24786977-6	2014	Our findings showed that ANGII has a role to affect expression of iron transport proteins in astrocytes in vitro and also suggested that ANGII might have a physiological function in brain iron homeostasis.	Iron	66-70	angiotensinogen	Homo sapiens	25-30
24786977-1	2014	The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain.	Iron	183-187	angiotensinogen	Homo sapiens	210-215
24786977-1	2014	The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain.	Iron	183-187	angiotensinogen	Homo sapiens	146-160
24786977-1	2014	The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain.	Iron	183-187	angiotensinogen	Homo sapiens	210-215
24786977-1	2014	The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain.	Iron	183-187	angiotensinogen	Homo sapiens	146-160
24786977-1	2014	The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANGII might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain.	Iron	183-187	angiotensinogen	Homo sapiens	210-215
24786977-3	2014	We demonstrated that ANGII could significantly inhibit transferrin-bound iron (Tf-Fe) uptake and iron release as well as the expression of transferrin receptor 1 (TfR1) and the iron exporter ferroportin 1 (Fpn1) in cultured astrocytes.	Iron	73-77	angiotensinogen	Homo sapiens	21-26
24786977-3	2014	We demonstrated that ANGII could significantly inhibit transferrin-bound iron (Tf-Fe) uptake and iron release as well as the expression of transferrin receptor 1 (TfR1) and the iron exporter ferroportin 1 (Fpn1) in cultured astrocytes.	Iron	73-77	transferrin	Homo sapiens	55-66
24786977-3	2014	We demonstrated that ANGII could significantly inhibit transferrin-bound iron (Tf-Fe) uptake and iron release as well as the expression of transferrin receptor 1 (TfR1) and the iron exporter ferroportin 1 (Fpn1) in cultured astrocytes.	Iron	82-84	angiotensinogen	Homo sapiens	21-26
24786977-3	2014	We demonstrated that ANGII could significantly inhibit transferrin-bound iron (Tf-Fe) uptake and iron release as well as the expression of transferrin receptor 1 (TfR1) and the iron exporter ferroportin 1 (Fpn1) in cultured astrocytes.	Iron	97-101	angiotensinogen	Homo sapiens	21-26
24865177-1	2014	MitoNEET is an outer mitochondrial membrane protein that, upon overexpression in white adipose tissue (WAT), exerts a positive impact on tissue expansion and whole-body lipid and carbohydrate homeostasis by altering mitochondrial matrix iron metabolism.	Iron	237-241	CDGSH iron sulfur domain 1	Mus musculus	0-8
24549883-3	2014	Here, we examined whether four of the subgroup Ib basic helix-loop-helix transcription factors (bHLH38, bHLH39, bHLH100, bHLH101), previously implicated in iron homeostasis in roots, also play a role in regulating iron metabolism in developing leaves.	Iron	156-160	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	104-110
24549883-8	2014	When grown in agar plates with reduced iron concentration, triple bhlh39 bhlh100 bhlh101 mutant plants were smaller than wild-type plants.	Iron	39-43	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	66-72
24622883-0	2014	Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism?	Iron	3-7	heat shock protein family A (Hsp70) member 5	Homo sapiens	84-112
24622883-2	2014	We hypothesized that the HDAC inhibitors and iron chelators would be synergistic with their effect on breast cancer cell line MCF7, because the HDAC inhibitors increase glucose-regulated protein 78 (Grp78) and the iron chelators reduce its expression.	Iron	45-49	heat shock protein family A (Hsp70) member 5	Homo sapiens	169-197
24622883-2	2014	We hypothesized that the HDAC inhibitors and iron chelators would be synergistic with their effect on breast cancer cell line MCF7, because the HDAC inhibitors increase glucose-regulated protein 78 (Grp78) and the iron chelators reduce its expression.	Iron	45-49	heat shock protein family A (Hsp70) member 5	Homo sapiens	199-204
24966834-0	2014	The role of TMPRSS6/matriptase-2 in iron regulation and anemia.	Iron	36-40	transmembrane serine protease 6	Homo sapiens	12-19
24921009-4	2014	According to the currently accepted view, ferrous iron transported out of the cell by ferroportin would be safely oxidized by ceruloplasmin to facilitate loading on transferrin.	Iron	42-54	transferrin	Homo sapiens	165-176
24845074-1	2014	Yellow stripe-like1 (YSL1) and YSL3 are involved in iron (Fe) and copper (Cu) translocation.	Iron	52-56	YELLOW STRIPE like 1	Arabidopsis thaliana	0-19
24845074-1	2014	Yellow stripe-like1 (YSL1) and YSL3 are involved in iron (Fe) and copper (Cu) translocation.	Iron	52-56	YELLOW STRIPE like 1	Arabidopsis thaliana	21-25
24845074-1	2014	Yellow stripe-like1 (YSL1) and YSL3 are involved in iron (Fe) and copper (Cu) translocation.	Iron	58-60	YELLOW STRIPE like 1	Arabidopsis thaliana	0-19
24845074-1	2014	Yellow stripe-like1 (YSL1) and YSL3 are involved in iron (Fe) and copper (Cu) translocation.	Iron	58-60	YELLOW STRIPE like 1	Arabidopsis thaliana	21-25
24966834-0	2014	The role of TMPRSS6/matriptase-2 in iron regulation and anemia.	Iron	36-40	transmembrane serine protease 6	Homo sapiens	20-32
24966834-5	2014	This review focuses on the current understanding of matriptase-2 biochemistry, and its role in iron metabolism and cancer progression.	Iron	95-99	transmembrane serine protease 6	Homo sapiens	52-64
24624902-6	2014	A series of amino acid-modifying reagents were screened for their effects on Mrs3p-mediated iron transport.	Iron	92-96	Fe(2+) transporter	Saccharomyces cerevisiae S288C	77-82
24607631-4	2014	Chemical analyses of samples showed that the fractional Fe solubility (%FeS) is much higher during NDS than that during DSE, and a strong inverse relationship of R(2)=0.967 between %FeS and total atmospheric iron loading were found, suggested that total Fe (FeT) is not controlling soluble Fe (FeS) during the sampling.	Iron	208-212	RNA-binding protein 9	Drosophila melanogaster	182-185
24607631-4	2014	Chemical analyses of samples showed that the fractional Fe solubility (%FeS) is much higher during NDS than that during DSE, and a strong inverse relationship of R(2)=0.967 between %FeS and total atmospheric iron loading were found, suggested that total Fe (FeT) is not controlling soluble Fe (FeS) during the sampling.	Iron	208-212	RNA-binding protein 9	Drosophila melanogaster	182-185
24655737-1	2014	Pantothenate kinase-associated neurodegeneration (PKAN) is the commonest, recessively inherited form of neurodegeneration with brain iron accumulation (NBIA) resulting from mutations in the pantothenate kinase 2 (PANK2) gene on chromosome 20.	Iron	133-137	pantothenate kinase 2	Homo sapiens	0-48
24690308-1	2014	The previously published method allowing the separation of non-ferric (iron-free) and ferric (iron-saturated) forms of human serum transferrin via capillary electrophoresis has been further developed.	Iron	71-75	transferrin	Homo sapiens	131-142
24655737-1	2014	Pantothenate kinase-associated neurodegeneration (PKAN) is the commonest, recessively inherited form of neurodegeneration with brain iron accumulation (NBIA) resulting from mutations in the pantothenate kinase 2 (PANK2) gene on chromosome 20.	Iron	133-137	pantothenate kinase 2	Homo sapiens	50-54
24655737-1	2014	Pantothenate kinase-associated neurodegeneration (PKAN) is the commonest, recessively inherited form of neurodegeneration with brain iron accumulation (NBIA) resulting from mutations in the pantothenate kinase 2 (PANK2) gene on chromosome 20.	Iron	133-137	pantothenate kinase 2	Homo sapiens	190-211
24655737-1	2014	Pantothenate kinase-associated neurodegeneration (PKAN) is the commonest, recessively inherited form of neurodegeneration with brain iron accumulation (NBIA) resulting from mutations in the pantothenate kinase 2 (PANK2) gene on chromosome 20.	Iron	133-137	pantothenate kinase 2	Homo sapiens	213-218
24655737-7	2014	Atypical genetically confirmed PKAN cases are sparsely reported and should be considered in the differential diagnosis of patients presenting with a progressive extrapyramidal syndrome particularly if the radiographic findings are suggestive of iron accumulation.	Iron	245-249	pantothenate kinase 2	Homo sapiens	31-35
24831516-5	2014	In this work, host iron sources that are used by Paracoccidioides spp.	Iron	19-23	sphingosine-1-phosphate phosphatase 1	Mus musculus	66-69
24690308-1	2014	The previously published method allowing the separation of non-ferric (iron-free) and ferric (iron-saturated) forms of human serum transferrin via capillary electrophoresis has been further developed.	Iron	94-98	transferrin	Homo sapiens	131-142
24690308-4	2014	The new method has allowed us to monitor the gradual iron saturation of transferrin by mixing the iron-free form of protein with the buffers with different concentrations of ferric ions.	Iron	53-57	transferrin	Homo sapiens	72-83
24690308-4	2014	The new method has allowed us to monitor the gradual iron saturation of transferrin by mixing the iron-free form of protein with the buffers with different concentrations of ferric ions.	Iron	98-102	transferrin	Homo sapiens	72-83
24668499-5	2014	The O O bond formation is performed by an iron(V) intermediate [Fe(V) (O)(OH)(LN4 )](2+) containing a cis-Fe(V) (O)(OH) unit.	Iron	42-46	FEV transcription factor, ETS family member	Homo sapiens	64-69
24668499-5	2014	The O O bond formation is performed by an iron(V) intermediate [Fe(V) (O)(OH)(LN4 )](2+) containing a cis-Fe(V) (O)(OH) unit.	Iron	42-46	FEV transcription factor, ETS family member	Homo sapiens	106-111
24668499-10	2014	Interplay between redox potentials to achieve the high oxidation state (Fe(V)  O) and the activation energy barrier for the following O O bond formation appears to be feasible through manipulation of the coordination environment of the iron site.	Iron	220-224	FEV transcription factor, ETS family member	Homo sapiens	72-77
24786230-1	2014	Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk.	Iron	23-27	transferrin	Homo sapiens	56-67
24379355-8	2014	In conclusion, the current study suggests that hepcidin can be directly regulated by insulin, and the suppressed liver hepcidin synthesis may be an important reason for the iron overload in DM2.	Iron	173-177	hepcidin antimicrobial peptide	Rattus norvegicus	119-127
24533562-0	2014	Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios.	Iron	0-4	pyruvate kinase L/R	Homo sapiens	136-140
23504249-4	2014	We previously published that Fe/Pd nanoparticles effectively dechlorinate PCB 77 to biphenyl, thus eliminating PCB-induced endothelial dysfunction using primary vascular endothelial cells.	Iron	29-31	pyruvate carboxylase	Homo sapiens	74-77
23504249-4	2014	We previously published that Fe/Pd nanoparticles effectively dechlorinate PCB 77 to biphenyl, thus eliminating PCB-induced endothelial dysfunction using primary vascular endothelial cells.	Iron	29-31	pyruvate carboxylase	Homo sapiens	111-114
23607437-3	2014	Because transferrin is a native chelator that regulates iron homeostasis, it may act as an anticancer agent in a similar manner as DFO.	Iron	56-60	transferrin	Homo sapiens	8-19
24464533-3	2014	Within few weeks, iron-depleted diet caused iron deficiency in young Sprague-Dawley rats, as reflected by a drop in hemoglobin, mean corpuscular volume, hepatic iron content and hepcidin mRNA in the liver.	Iron	18-22	hepcidin antimicrobial peptide	Rattus norvegicus	178-186
24379355-0	2014	Hepcidin is directly regulated by insulin and plays an important role in iron overload in streptozotocin-induced diabetic rats.	Iron	73-77	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
24379355-2	2014	We hypothesize that hepcidin may be directly regulated by insulin and play an important role in iron overload in DM2.	Iron	96-100	hepcidin antimicrobial peptide	Rattus norvegicus	20-28
24612808-0	2014	In vitro iron absorption of alpha-lactalbumin hydrolysate-iron and beta-lactoglobulin hydrolysate-iron complexes.	Iron	9-13	lactalbumin alpha	Homo sapiens	28-45
24369896-7	2014	The concentrations of magnesium, iron and zinc positively correlated with IL-8.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24612808-0	2014	In vitro iron absorption of alpha-lactalbumin hydrolysate-iron and beta-lactoglobulin hydrolysate-iron complexes.	Iron	58-62	lactalbumin alpha	Homo sapiens	28-45
24612808-0	2014	In vitro iron absorption of alpha-lactalbumin hydrolysate-iron and beta-lactoglobulin hydrolysate-iron complexes.	Iron	58-62	lactalbumin alpha	Homo sapiens	28-45
24612808-1	2014	To study the feasibility of promoting iron absorption by peptides derived from alpha-lactalbumin and beta-lactoglobulin, the present work examined the transport of iron across Caco-2 monolayer cell as in vitro model.	Iron	38-42	lactalbumin alpha	Homo sapiens	79-96
24621584-0	2014	De novo WDR45 mutation in a patient showing clinically Rett syndrome with childhood iron deposition in brain.	Iron	84-88	WD repeat domain 45	Homo sapiens	8-13
24621584-2	2014	We identified a de novo WDR45 mutation, which caused a subtype of neurodegeneration with brain iron accumulation, in a patient showing clinically typical RTT.	Iron	95-99	WD repeat domain 45	Homo sapiens	24-29
24661630-2	2014	Emerging evidence indicates that iron chelation therapy (ICT) could reduce mortality and improve survival in transfusion-dependent MDS patients, especially those classified as International Prognostic Scoring System (IPSS) Low or Intermediate-1 (Low/Int-1).	Iron	33-37	Wnt family member 1	Homo sapiens	250-255
24803710-3	2014	This present study investigated the effects of dephytinise from soy protein isolate (SPI) on iron binding capacity and degree of hydrolysis.	Iron	93-97	chromogranin A	Homo sapiens	85-88
24803710-8	2014	Flavourzyme might be the best choice for producing peptides with iron binding capacity from SPI and middle degree of hydrolysis would be benefitable to this process.	Iron	65-69	chromogranin A	Homo sapiens	92-95
24714688-3	2014	Here we summarize recent microscopy-based observations to the effect that iron can have major effects on erythrocyte morphology, on erythrocyte deformability and on both fibrinogen polymerization and the consequent structure of the fibrin clots formed, each of which contributes significantly and negatively to such diseases.	Iron	74-78	fibrinogen beta chain	Homo sapiens	170-180
24581673-6	2014	Moreover, PHD2 inhibitors may increase the endogenous circulating iron availability via suppression of hepcidin, a master regulator of iron homeostasis which further reduces the need for exogenous intravenous iron administration for effective erythropoiesis in renal anemia patients.	Iron	66-70	egl-9 family hypoxia inducible factor 1	Homo sapiens	10-14
24581673-6	2014	Moreover, PHD2 inhibitors may increase the endogenous circulating iron availability via suppression of hepcidin, a master regulator of iron homeostasis which further reduces the need for exogenous intravenous iron administration for effective erythropoiesis in renal anemia patients.	Iron	135-139	egl-9 family hypoxia inducible factor 1	Homo sapiens	10-14
24581673-6	2014	Moreover, PHD2 inhibitors may increase the endogenous circulating iron availability via suppression of hepcidin, a master regulator of iron homeostasis which further reduces the need for exogenous intravenous iron administration for effective erythropoiesis in renal anemia patients.	Iron	135-139	egl-9 family hypoxia inducible factor 1	Homo sapiens	10-14
24663493-4	2014	Streptococcus can directly extract iron from host iron-containing proteins such as ferritin, transferrin, lactoferrin and hemoproteins, or indirectly by relying on the employment of specialized secreted hemophores (heme chelators) and small siderophore molecules (high affinity ferric chelators).	Iron	35-39	transferrin	Homo sapiens	93-104
24586035-2	2014	We report regulation of siderophore-mediated iron acquisition and ROS resistance by the NADPH oxidase (NOX), the redox activating yes-associated protein 1 (YAP1) regulator, and the high-osmolarity glycerol 1 (HOG1) mitogen-activated protein kinase (MAPK).	Iron	45-49	CC77DRAFT_947590	Alternaria alternata	88-101
24586035-2	2014	We report regulation of siderophore-mediated iron acquisition and ROS resistance by the NADPH oxidase (NOX), the redox activating yes-associated protein 1 (YAP1) regulator, and the high-osmolarity glycerol 1 (HOG1) mitogen-activated protein kinase (MAPK).	Iron	45-49	CC77DRAFT_947590	Alternaria alternata	103-106
24682751-0	2014	Angiotensin II inhibits iron uptake and release in cultured neurons.	Iron	24-28	angiotensinogen	Homo sapiens	0-14
24586035-5	2014	Exogenous addition of iron at least partially rescues ROS sensitivity seen for NPS6, YAP1, HOG1, and NOX mutants.	Iron	22-26	CC77DRAFT_947590	Alternaria alternata	101-104
24662374-1	2014	Ferritin H, the major iron storage protein, has essential functions in early embryonic development as well as in adult liver and intestine.	Iron	22-26	ferritin mitochondrial	Mus musculus	0-10
24682751-1	2014	Based on the well-confirmed roles of angiotensin II (ANGII) in iron transport of peripheral organs and cells, the causative link of excess brain iron with and the involvement of ANGII in neurodegenerative disorders, we speculated that ANGII might also have an effect on expression of iron transport proteins in the brain.	Iron	63-67	angiotensinogen	Homo sapiens	37-51
24682751-3	2014	Our findings demonstrated for the first time that ANGII significantly reduced transferrin-bound iron and non-transferrin bound iron uptake and iron release as well as expression of two major iron uptake proteins transferrin receptor 1 and divalent metal transporter 1 and the key iron exporter ferroportin 1 in cultured neurons.	Iron	127-131	angiotensinogen	Homo sapiens	50-55
24682751-3	2014	Our findings demonstrated for the first time that ANGII significantly reduced transferrin-bound iron and non-transferrin bound iron uptake and iron release as well as expression of two major iron uptake proteins transferrin receptor 1 and divalent metal transporter 1 and the key iron exporter ferroportin 1 in cultured neurons.	Iron	127-131	angiotensinogen	Homo sapiens	50-55
24682751-3	2014	Our findings demonstrated for the first time that ANGII significantly reduced transferrin-bound iron and non-transferrin bound iron uptake and iron release as well as expression of two major iron uptake proteins transferrin receptor 1 and divalent metal transporter 1 and the key iron exporter ferroportin 1 in cultured neurons.	Iron	127-131	angiotensinogen	Homo sapiens	50-55
24682751-4	2014	The findings suggested that endogenous ANGII might have a physiological significance in brain iron metabolism.	Iron	94-98	angiotensinogen	Homo sapiens	39-44
24682751-1	2014	Based on the well-confirmed roles of angiotensin II (ANGII) in iron transport of peripheral organs and cells, the causative link of excess brain iron with and the involvement of ANGII in neurodegenerative disorders, we speculated that ANGII might also have an effect on expression of iron transport proteins in the brain.	Iron	63-67	angiotensinogen	Homo sapiens	53-58
24682751-3	2014	Our findings demonstrated for the first time that ANGII significantly reduced transferrin-bound iron and non-transferrin bound iron uptake and iron release as well as expression of two major iron uptake proteins transferrin receptor 1 and divalent metal transporter 1 and the key iron exporter ferroportin 1 in cultured neurons.	Iron	96-100	angiotensinogen	Homo sapiens	50-55
24682751-3	2014	Our findings demonstrated for the first time that ANGII significantly reduced transferrin-bound iron and non-transferrin bound iron uptake and iron release as well as expression of two major iron uptake proteins transferrin receptor 1 and divalent metal transporter 1 and the key iron exporter ferroportin 1 in cultured neurons.	Iron	96-100	transferrin	Homo sapiens	78-89
24682751-3	2014	Our findings demonstrated for the first time that ANGII significantly reduced transferrin-bound iron and non-transferrin bound iron uptake and iron release as well as expression of two major iron uptake proteins transferrin receptor 1 and divalent metal transporter 1 and the key iron exporter ferroportin 1 in cultured neurons.	Iron	127-131	angiotensinogen	Homo sapiens	50-55
24789352-5	2014	Iron-positive cells were quantified histologically, and the expression of iron uptake (transferrin and transferrin receptor), storage (ferritin) and export (ferroportin) genes was examined by real-time RT-PCR assay.	Iron	74-78	transferrin	Homo sapiens	87-98
24951989-1	2014	INTRODUCTION: The presence of abnormalities in the metabolic pathways of iron and liver functioning can produce insulin resistance or metabolic syndrome.	Iron	73-77	insulin	Homo sapiens	112-119
24789352-9	2014	The mRNA expression of iron uptake and storage genes transferrin and ferritin were significantly increased in GOLD 4 COPD lungs compared to donors (6.9 and 3.22 fold increase, respectively).	Iron	23-27	transferrin	Homo sapiens	53-64
24583810-4	2014	In the presence of ferric ion (100 muM), PFOS (20 muM) decreased to below the detection limit within 48 h, with the rate constant of 1.67 d(-1), which was 50 times higher than that by direct photolysis (0.033 d(-1)).	Iron	19-29	latexin	Homo sapiens	35-38
24583810-4	2014	In the presence of ferric ion (100 muM), PFOS (20 muM) decreased to below the detection limit within 48 h, with the rate constant of 1.67 d(-1), which was 50 times higher than that by direct photolysis (0.033 d(-1)).	Iron	19-29	latexin	Homo sapiens	50-53
24808863-1	2014	The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis.	Iron	83-87	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
24492533-2	2014	In this work, the reactions of C-H bond activation by two series of iron-oxo ( (Fe(IV)), (Fe(V)), (Fe(VI))) and -nitrido model complexes ( (Fe(IV)), (Fe(V)), (Fe(VI))) with a nearly identical coordination geometry but varying iron oxidation states ranging from iv to vi were comprehensively investigated using density functional theory.	Iron	68-72	FEV transcription factor, ETS family member	Homo sapiens	149-155
24492533-2	2014	In this work, the reactions of C-H bond activation by two series of iron-oxo ( (Fe(IV)), (Fe(V)), (Fe(VI))) and -nitrido model complexes ( (Fe(IV)), (Fe(V)), (Fe(VI))) with a nearly identical coordination geometry but varying iron oxidation states ranging from iv to vi were comprehensively investigated using density functional theory.	Iron	226-230	FEV transcription factor, ETS family member	Homo sapiens	89-95
24492533-2	2014	In this work, the reactions of C-H bond activation by two series of iron-oxo ( (Fe(IV)), (Fe(V)), (Fe(VI))) and -nitrido model complexes ( (Fe(IV)), (Fe(V)), (Fe(VI))) with a nearly identical coordination geometry but varying iron oxidation states ranging from iv to vi were comprehensively investigated using density functional theory.	Iron	226-230	FEV transcription factor, ETS family member	Homo sapiens	149-155
24808863-3	2014	Hepcidin binds ferroportin, the only cellular iron exporter, causing the internalization and degradation of both.	Iron	46-50	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
24808863-4	2014	Thus hepcidin blocks iron export from the key cells for dietary iron absorption (enterocytes), recycling of hemoglobin iron (the macrophages) and the release of storage iron from hepatocytes, resulting in the reduction of systemic iron availability.	Iron	21-25	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
24808863-4	2014	Thus hepcidin blocks iron export from the key cells for dietary iron absorption (enterocytes), recycling of hemoglobin iron (the macrophages) and the release of storage iron from hepatocytes, resulting in the reduction of systemic iron availability.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
24808863-4	2014	Thus hepcidin blocks iron export from the key cells for dietary iron absorption (enterocytes), recycling of hemoglobin iron (the macrophages) and the release of storage iron from hepatocytes, resulting in the reduction of systemic iron availability.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
24808863-4	2014	Thus hepcidin blocks iron export from the key cells for dietary iron absorption (enterocytes), recycling of hemoglobin iron (the macrophages) and the release of storage iron from hepatocytes, resulting in the reduction of systemic iron availability.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
24808863-4	2014	Thus hepcidin blocks iron export from the key cells for dietary iron absorption (enterocytes), recycling of hemoglobin iron (the macrophages) and the release of storage iron from hepatocytes, resulting in the reduction of systemic iron availability.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
24808863-5	2014	The BMP/HJV/SMAD pathway is the major regulator of hepcidin expression that responds to iron status.	Iron	88-92	hepcidin antimicrobial peptide	Rattus norvegicus	51-59
24808863-7	2014	In some pathological conditions hepcidin level is inadequately elevated and reduces iron availability in the body, resulting in anemia.	Iron	84-88	hepcidin antimicrobial peptide	Rattus norvegicus	32-40
24782651-0	2014	TMPRSS6 rs855791 polymorphism influences the susceptibility to iron deficiency anemia in women at reproductive age.	Iron	63-67	transmembrane serine protease 6	Homo sapiens	0-7
25050219-3	2014	We argue that upon contact with redox iron, fibrinogen is converted to a hydrophobic fibrin-like polymer that coats tumor cells and provides protection from immune-mediated destruction.	Iron	38-42	fibrinogen beta chain	Homo sapiens	44-54
24860503-3	2014	HO-1 releases Fe(2+) from heme, and the ferritin heavy chain (FHC) ferroxidase oxidizes Fe(2+) to catalytically inactive Fe(3+) inside ferritin.	Iron	14-16	heme oxygenase 1	Mus musculus	0-4
24860503-3	2014	HO-1 releases Fe(2+) from heme, and the ferritin heavy chain (FHC) ferroxidase oxidizes Fe(2+) to catalytically inactive Fe(3+) inside ferritin.	Iron	88-90	heme oxygenase 1	Mus musculus	0-4
24670063-6	2014	In previous structural studies, we have shown that the distribution of H55 conformations is weighted strongly toward the external position when the DHP heme Fe is 5-coordinated.	Iron	157-159	dihydropyrimidinase	Homo sapiens	148-151
24782651-1	2014	BACKGROUND: Genome-wide-association studies have identified the TMPRSS6 polymorphism rs855791 has the strongest association with red blood cell indices or iron parameters in general population.	Iron	155-159	transmembrane serine protease 6	Homo sapiens	64-71
24649965-9	2014	These observations can be explained if the iron-sulfur clusters are involved in stabilizing the electron; the ~50 ms residence time of the electron on FA or FB is sufficiently long to allow cytochrome c6 to reduce P700(+), thereby eliminating the recombination channel.	Iron	43-47	cytochrome c, somatic	Homo sapiens	190-202
24513321-0	2014	Alzheimer"s disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis.	Iron	120-124	amyloid beta precursor protein	Homo sapiens	60-85
24513321-1	2014	The neurotoxicity of amyloid beta (Abeta), a major cleavage product of the amyloid precursor protein (APP), is enhanced by iron, as found in the amyloid plaques of Alzheimer"s disease (AD) patients.	Iron	123-127	amyloid beta precursor protein	Homo sapiens	21-33
24513321-1	2014	The neurotoxicity of amyloid beta (Abeta), a major cleavage product of the amyloid precursor protein (APP), is enhanced by iron, as found in the amyloid plaques of Alzheimer"s disease (AD) patients.	Iron	123-127	amyloid beta precursor protein	Homo sapiens	35-40
24513321-1	2014	The neurotoxicity of amyloid beta (Abeta), a major cleavage product of the amyloid precursor protein (APP), is enhanced by iron, as found in the amyloid plaques of Alzheimer"s disease (AD) patients.	Iron	123-127	amyloid beta precursor protein	Homo sapiens	75-100
24725620-3	2014	Using HL-1 cell and B6D2F1 mouse models, we further determined the impact of iron load on proteolysis of the giant sarcomeric protein titin.	Iron	77-81	titin	Mus musculus	134-139
24573684-2	2014	Initially, the Fe-S clusters are assembled on a conserved scaffold protein, iron-sulfur cluster scaffold protein (ISCU), in coordination with iron and sulfur donor proteins in human mitochondria.	Iron	15-19	iron-sulfur cluster assembly enzyme	Homo sapiens	114-118
24725620-10	2014	In HL-1 cells and ventricular myocardium of B6D2F1 mice overloaded with iron, the titin-stained pattern of sarcomeric structure became disrupted.	Iron	72-76	titin	Mus musculus	82-87
24573684-2	2014	Initially, the Fe-S clusters are assembled on a conserved scaffold protein, iron-sulfur cluster scaffold protein (ISCU), in coordination with iron and sulfur donor proteins in human mitochondria.	Iron	76-80	iron-sulfur cluster assembly enzyme	Homo sapiens	114-118
24725620-11	2014	Gel electrophoresis of iron-overloaded mouse myocardial tissue further showed significant decrease in the amount of titin isoforms and increase in titin degradation products.	Iron	23-27	titin	Mus musculus	116-121
24725620-11	2014	Gel electrophoresis of iron-overloaded mouse myocardial tissue further showed significant decrease in the amount of titin isoforms and increase in titin degradation products.	Iron	23-27	titin	Mus musculus	147-152
24803998-13	2014	The negative correlation between serum ferritin concentrations and ALT suggests that the impairment of hepatic function negatively affect IGF-I synthesis in these patients due to iron toxicity, even in the absence of hepatitis.	Iron	179-183	insulin like growth factor 1	Homo sapiens	138-143
24685134-0	2014	Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function.	Iron	0-4	tumor protein p53	Homo sapiens	26-29
24685134-0	2014	Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function.	Iron	0-4	tumor protein p53	Homo sapiens	60-63
24685134-0	2014	Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function.	Iron	0-4	tumor protein p53	Homo sapiens	60-63
24685134-3	2014	Here, we report that the tumor suppressor protein p53 is downregulated during iron excess.	Iron	78-82	tumor protein p53	Homo sapiens	50-53
24685134-5	2014	Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation.	Iron	37-41	tumor protein p53	Homo sapiens	75-78
24685134-5	2014	Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation.	Iron	37-41	tumor protein p53	Homo sapiens	145-148
24685134-5	2014	Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation.	Iron	195-199	tumor protein p53	Homo sapiens	75-78
24685134-5	2014	Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation.	Iron	195-199	tumor protein p53	Homo sapiens	145-148
24685134-6	2014	Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy.	Iron	49-53	tumor protein p53	Homo sapiens	93-96
24685134-6	2014	Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy.	Iron	158-162	tumor protein p53	Homo sapiens	93-96
24685134-6	2014	Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy.	Iron	158-162	tumor protein p53	Homo sapiens	93-96
24124891-6	2014	This antioxidant effect of FTH restrains JNK activation, whereas JNK activation inhibits FTH expression, a cross talk that controls metabolic adaptation to cellular Fe overload associated with systemic infections.	Iron	165-167	mitogen-activated protein kinase 8	Homo sapiens	65-68
24501215-8	2014	Ad.IL-6 increased hepatic hepcidin messenger RNA levels and decreased serum iron concentrations in Alk2- but not Alk3-deficient mice.	Iron	76-80	interleukin 6	Mus musculus	0-7
24521359-7	2014	The pro-inflammatory cytokine IL-1beta facilitates divalent metal transporter 1 (DMT1)-induced beta-cell iron uptake and consequently ROS formation and apoptosis, and we propose that this mechanism provides the relay between inflammation and oxidative beta-cell damage.	Iron	105-109	interleukin 1 beta	Homo sapiens	30-38
28788592-4	2014	It was supposed that the higher affinity of iron to steam would be attributed to the enhanced oxidation of P92 in pure steam, and the much easier transport of hydroxyl would account for the significant difference induced by gas switch.	Iron	44-48	advillin	Homo sapiens	107-110
24675597-1	2014	The structure of the delta1p phase in the iron-zinc system has been refined by single-crystal synchrotron X-ray diffraction combined with scanning transmission electron microscopy.	Iron	42-46	delta like non-canonical Notch ligand 1	Homo sapiens	21-28
24675597-6	2014	The bonding features in the delta1p phase are discussed in comparison with those in the Gamma and zeta phases in the iron-zinc system.	Iron	117-121	delta like non-canonical Notch ligand 1	Homo sapiens	28-35
24741667-9	2014	Interestingly, in addition to providing neuroprotection via Nrf2 signaling, EC diminished heme oxygenase-1 induction and brain iron deposition via an Nrf2-independent pathway that downregulated ICH-induced activating protein-1 activation and decreased matrix metalloproteinase 9 activity, lipocalin-2 levels, iron-dependent cell death, and ferroptosis-related gene expression.	Iron	127-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
24501215-10	2014	These results demonstrate that the ability of IL-6 to induce hepatic hepcidin gene expression and reduce serum iron concentrations is dependent on the BMP type I receptor Alk3.	Iron	111-115	interleukin 6	Mus musculus	46-50
24333084-7	2014	RESULTS: Measurable total and non-transferrin bound iron were present in the extracellular fluid of paediatric packs on day 3.	Iron	52-56	transferrin	Homo sapiens	34-45
24496804-0	2014	Insulin resistance modulates iron-related proteins in adipose tissue.	Iron	29-33	insulin	Homo sapiens	0-7
24531910-5	2014	Iron uptake in cells pre-incubated with 20 and 30 muM Fe was inhibited by CaCl2 (500 muM).	Iron	0-4	latexin	Homo sapiens	50-53
24531910-5	2014	Iron uptake in cells pre-incubated with 20 and 30 muM Fe was inhibited by CaCl2 (500 muM).	Iron	0-4	latexin	Homo sapiens	85-88
24531910-5	2014	Iron uptake in cells pre-incubated with 20 and 30 muM Fe was inhibited by CaCl2 (500 muM).	Iron	54-56	latexin	Homo sapiens	50-53
24531910-5	2014	Iron uptake in cells pre-incubated with 20 and 30 muM Fe was inhibited by CaCl2 (500 muM).	Iron	54-56	latexin	Homo sapiens	85-88
24531910-6	2014	Iron uptake decreased in cells cultured with tannic acid (300 muM) and CaCl2 (500-1,000 muM) (two-way ANOVA, p = 0.002).	Iron	0-4	latexin	Homo sapiens	62-65
24531910-6	2014	Iron uptake decreased in cells cultured with tannic acid (300 muM) and CaCl2 (500-1,000 muM) (two-way ANOVA, p = 0.002).	Iron	0-4	latexin	Homo sapiens	88-91
24531910-3	2014	Caco-2 cells were incubated with iron (10-30 muM) with or without CaCl2 (500 and 1,000 muM) for 24 h. Then, cells were challenged with phytic acid (50-150 muM); pectin (50-150 nM) or tannic acid (100-500 muM) for another 24 h. Finally, (55)Fe (10 muM) uptake was determined.	Iron	33-37	latexin	Homo sapiens	45-48
24496804-1	2014	OBJECTIVE Circulating markers of iron overload are associated with insulin resistance.	Iron	33-37	insulin	Homo sapiens	67-74
24496804-3	2014	We hypothesized that gene expression markers of iron metabolism in AT could be associated with insulin action.	Iron	48-52	insulin	Homo sapiens	95-102
24496804-8	2014	CONCLUSIONS These results suggest that iron overload impacts on AT in association with insulin resistance.	Iron	39-43	insulin	Homo sapiens	87-94
24447894-4	2014	NO2 oxidizes iron(II)cytochrome c with a second-order rate constant of (6.6+-0.5)x10(7) M(-1) s(-1) at pH 7.4; formation of iron(III)cytochrome c is quantitative.	Iron	13-17	cytochrome c, somatic	Homo sapiens	21-33
24398642-4	2014	RESULTS: We found strong associations between HFE and TMPRSS6 genotypes and mother"s haemoglobin levels early in pregnancy (P-values are all &lt;= 4.1 x 10(-5)) and a genetic score comprised of alleles at these loci was even more strongly associated with haemoglobin levels (P=3.0 x 10(-18)), suggesting that this was a good instrument to use to look at the effect of prenatal iron levels on offspring cognition.	Iron	377-381	transmembrane serine protease 6	Homo sapiens	54-61
24447894-4	2014	NO2 oxidizes iron(II)cytochrome c with a second-order rate constant of (6.6+-0.5)x10(7) M(-1) s(-1) at pH 7.4; formation of iron(III)cytochrome c is quantitative.	Iron	13-17	cytochrome c, somatic	Homo sapiens	133-145
24495550-2	2014	HIF-1 is downregulated by iron-containing 2-oxoglutarate-dependent enzymes that require ascorbate as a cofactor.	Iron	26-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
24447894-5	2014	Based on these rate constants, we propose that the reaction with iron(II)cytochrome c proceeds via a mechanism in which 90% of NO2 oxidizes the iron center directly-most probably via reaction at the solvent-accessible heme edge-whereas 10% oxidizes the amino acid residues to the corresponding radicals, which, in turn, oxidize iron(II).	Iron	65-69	cytochrome c, somatic	Homo sapiens	73-85
24495550-5	2014	Ascorbate inhibited HIF-1 activity most dramatically with all mechanisms of iron competition.	Iron	76-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
24447894-6	2014	Iron(II)cytochrome c is also oxidized by peroxynitrite in the presence of CO2 to iron(III)cytochrome c, with a yield of ~60% relative to peroxynitrite.	Iron	0-4	cytochrome c, somatic	Homo sapiens	8-20
24447894-6	2014	Iron(II)cytochrome c is also oxidized by peroxynitrite in the presence of CO2 to iron(III)cytochrome c, with a yield of ~60% relative to peroxynitrite.	Iron	0-4	cytochrome c, somatic	Homo sapiens	90-102
24447894-6	2014	Iron(II)cytochrome c is also oxidized by peroxynitrite in the presence of CO2 to iron(III)cytochrome c, with a yield of ~60% relative to peroxynitrite.	Iron	81-85	cytochrome c, somatic	Homo sapiens	8-20
24447894-6	2014	Iron(II)cytochrome c is also oxidized by peroxynitrite in the presence of CO2 to iron(III)cytochrome c, with a yield of ~60% relative to peroxynitrite.	Iron	81-85	cytochrome c, somatic	Homo sapiens	90-102
23956199-5	2014	We found that Fer2LCH mRNA contains an iron-responsive element, suggesting this ferritin subunit is subject to translational control.	Iron	39-43	ferritin	Bombyx mori	80-88
24970985-2	2014	Excess body iron has been positively associated with insulin resistance, type 2 diabetes and obesity.	Iron	12-16	insulin	Homo sapiens	53-60
24530569-0	2014	5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1.	Iron	36-48	heme oxygenase 1	Mus musculus	76-92
24530569-3	2014	Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the rate-limiting step in the oxidative degradation of heme to free iron, biliverdin and carbon monoxide.	Iron	128-132	heme oxygenase 1	Mus musculus	0-21
24813409-5	2014	Iron status is also important to the effective management of RLS.	Iron	0-4	RLS1	Homo sapiens	61-64
24468676-10	2014	Emerging data suggests that proteins containing a hemerythrin-domain, such as FBXL5, may serve to connect iron sensing to O2-sensing in both bacteria and humans.	Iron	106-110	F-box and leucine rich repeat protein 5	Homo sapiens	78-83
24500887-11	2014	In the uremic group, Fe administration did not show any effect on ssDNA expression, but reduced Runx2 and Pit-1 expressions.	Iron	21-23	RUNX family transcription factor 2	Rattus norvegicus	96-101
24225901-4	2014	Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6.	Iron	18-22	interleukin 6	Homo sapiens	234-247
24225901-4	2014	Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6.	Iron	99-103	interleukin 6	Homo sapiens	234-247
24500887-11	2014	In the uremic group, Fe administration did not show any effect on ssDNA expression, but reduced Runx2 and Pit-1 expressions.	Iron	21-23	POU class 1 homeobox 1	Rattus norvegicus	106-111
24549117-9	2014	The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl.	Iron	19-23	FER-like regulator of iron uptake	Arabidopsis thaliana	73-77
24500887-12	2014	CONCLUSION: Fe suppressed the development of vascular calcification through the prevention of Pit-1 and vascular smooth muscle cell osteoblastic transdifferentiation.	Iron	12-14	POU class 1 homeobox 1	Rattus norvegicus	94-99
23836416-2	2014	Abeta has high affinity for iron and copper resulting in the generation of neurotoxic hydrogen peroxide, oxidative stress and free radical formation.	Iron	28-32	amyloid beta precursor protein	Homo sapiens	0-5
24390086-1	2014	Pirin, a product of the PIR gene, is an iron-binding protein acting as a transcriptional coregulator implicated in the regulation of the NF-kappaB-related transcription via interaction with RelA (p65), as well as BCL3 and NF-kappaB1 (p50) proteins.	Iron	40-44	pirin	Homo sapiens	0-5
24390086-1	2014	Pirin, a product of the PIR gene, is an iron-binding protein acting as a transcriptional coregulator implicated in the regulation of the NF-kappaB-related transcription via interaction with RelA (p65), as well as BCL3 and NF-kappaB1 (p50) proteins.	Iron	40-44	pirin	Homo sapiens	24-27
23775841-11	2014	At early and late CFPE, serum IGF-1 was directly correlated with FEV1 %, serum iron, hemoglobin concentration, and transferrin saturation (TSAT) and indirectly correlated with alpha-1-antitrypsin.	Iron	79-83	insulin like growth factor 1	Homo sapiens	30-35
24103305-0	2014	In vivo MRI detection of carotid atherosclerotic lesions and kidney inflammation in ApoE-deficient mice by using LOX-1 targeted iron nanoparticles.	Iron	128-132	apolipoprotein E	Mus musculus	84-88
23775841-14	2014	Close correlations among IGF-1 and iron-related hematologic parameters suggest that IGF-1 may participate in CF iron homeostasis, another process that is known to be influenced by CFPE.	Iron	35-39	insulin like growth factor 1	Homo sapiens	84-89
24365882-10	2014	In contrast, a decreased TfR1 level was detected by IL-6 and iron alone, whereas combination of iron and AP cytokines (mainly IL-6) abrogated the downregulation of TfR1.	Iron	96-100	interleukin 6	Rattus norvegicus	126-130
24111973-5	2014	Treatment with ABA also led to increased Fe concentrations in the xylem sap, partially because of the up-regulation of AtFRD3, AtYSL2 and AtNAS1, genes related to long-distance transport of Fe.	Iron	190-192	MATE efflux family protein	Arabidopsis thaliana	119-125
24695004-2	2014	Fe-based superconductors bridge a gap between MgB2 and the cuprate high temperature superconductors as they exhibit multiband character and transition temperatures up to around 55 K. Investigating Fe-based superconductors thus promises answers to fundamental questions concerning the Cooper pairing mechanism, competition between magnetic and superconducting phases, and a wide variety of electronic correlation effects.	Iron	0-2	secretoglobin family 2A member 1	Homo sapiens	46-50
24365882-8	2014	This uptake was further enhanced in the presence of AP cytokines with a maximum iron uptake (481 +- 25.81 microg/g of protein) after concomitant administration of IL-6 + iron to cultured hepatocytes.	Iron	80-84	interleukin 6	Rattus norvegicus	163-167
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Iron	199-203	cystathionine beta-synthase	Homo sapiens	60-87
24160470-6	2014	IL-10- / - mice treated with CD52 mAb showed a reduction in the percentage of CD4+ and CD4+CD45+ T cells in blood and weight loss typically associated with colonic inflammation, serum levels of EPO, the expression of liver hepcidin mRNA and total Smad1 protein, while they showed an increase in Hb concentrations, haematocrit, levels of serum Fe, transferrin saturation and splenic Fe stores.	Iron	343-345	interleukin 10	Mus musculus	0-5
24160470-6	2014	IL-10- / - mice treated with CD52 mAb showed a reduction in the percentage of CD4+ and CD4+CD45+ T cells in blood and weight loss typically associated with colonic inflammation, serum levels of EPO, the expression of liver hepcidin mRNA and total Smad1 protein, while they showed an increase in Hb concentrations, haematocrit, levels of serum Fe, transferrin saturation and splenic Fe stores.	Iron	343-345	CD52 antigen	Mus musculus	29-33
24160470-6	2014	IL-10- / - mice treated with CD52 mAb showed a reduction in the percentage of CD4+ and CD4+CD45+ T cells in blood and weight loss typically associated with colonic inflammation, serum levels of EPO, the expression of liver hepcidin mRNA and total Smad1 protein, while they showed an increase in Hb concentrations, haematocrit, levels of serum Fe, transferrin saturation and splenic Fe stores.	Iron	382-384	interleukin 10	Mus musculus	0-5
24160470-6	2014	IL-10- / - mice treated with CD52 mAb showed a reduction in the percentage of CD4+ and CD4+CD45+ T cells in blood and weight loss typically associated with colonic inflammation, serum levels of EPO, the expression of liver hepcidin mRNA and total Smad1 protein, while they showed an increase in Hb concentrations, haematocrit, levels of serum Fe, transferrin saturation and splenic Fe stores.	Iron	382-384	CD52 antigen	Mus musculus	29-33
24676135-7	2014	Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions.	Iron	148-152	interleukin 1 beta	Homo sapiens	29-37
24676135-7	2014	Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions.	Iron	148-152	interleukin 6	Homo sapiens	39-43
24676135-7	2014	Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions.	Iron	148-152	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
24676135-7	2014	Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions.	Iron	148-152	tumor necrosis factor	Homo sapiens	54-63
24676135-8	2014	Low iron conditions in pure culture increased Salmonella invasion correlating with an increase in IL-8 release.	Iron	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
24676135-10	2014	Salmonella in high iron fermentation effluents had decreased invasion efficiency (-77.1%) and cellular TNF-alpha release compared to normal iron effluent.	Iron	19-23	tumor necrosis factor	Homo sapiens	103-112
24767394-9	2014	Both serum ferritin and transferrin saturation tended to increase after repeated transfusions, leading to secondary iron overload.	Iron	116-120	transferrin	Homo sapiens	24-35
24671940-1	2014	For decades, a link between increased levels of iron and areas of Alzheimer"s disease (AD) pathology has been recognized, including AD lesions comprised of the peptide beta-amyloid (Abeta).	Iron	48-52	amyloid beta precursor protein	Homo sapiens	182-187
24671940-2	2014	Despite many observations of this association, the relationship between Abeta and iron is poorly understood.	Iron	82-86	amyloid beta precursor protein	Homo sapiens	72-77
24671940-4	2014	We report Abeta to be capable of accumulating iron(III) within amyloid aggregates, with this process resulting in Abeta-mediated reduction of iron(III) to a redox-active iron(II) phase.	Iron	46-50	amyloid beta precursor protein	Homo sapiens	10-15
24671940-4	2014	We report Abeta to be capable of accumulating iron(III) within amyloid aggregates, with this process resulting in Abeta-mediated reduction of iron(III) to a redox-active iron(II) phase.	Iron	46-50	amyloid beta precursor protein	Homo sapiens	114-119
24671940-5	2014	Additionally, we show that the presence of aluminium increases the reductive capacity of Abeta, enabling the redox cycling of the iron.	Iron	130-134	amyloid beta precursor protein	Homo sapiens	89-94
24671940-6	2014	These results demonstrate the ability of Abeta to accumulate iron, offering an explanation for previously observed local increases in iron concentration associated with AD lesions.	Iron	61-65	amyloid beta precursor protein	Homo sapiens	41-46
24671940-6	2014	These results demonstrate the ability of Abeta to accumulate iron, offering an explanation for previously observed local increases in iron concentration associated with AD lesions.	Iron	134-138	amyloid beta precursor protein	Homo sapiens	41-46
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Iron	199-203	cystathionine beta-synthase	Homo sapiens	89-92
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Iron	199-203	cystathionine beta-synthase	Homo sapiens	143-146
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	15-19	Aft2p	Saccharomyces cerevisiae S288C	62-66
24659891-3	2014	Iron depletion had to be achieved by removing 350 cc of blood every 10-15 d according to baseline hemoglobin values and venesection tolerance, until ferritin &lt; 30 ng/mL and/or transferrin saturation (TS) &lt; 25%.	Iron	0-4	transferrin	Homo sapiens	179-190
24641804-9	2014	This iron-induced apoptosis was linked to enhanced caspase 8, reduced Bcl-2, Bcl-xL, phosphorylated Akt and GATA-4.	Iron	5-9	BCL2 apoptosis regulator	Homo sapiens	70-75
24659891-9	2014	In patients followed-up at two years (n = 35), ALT, AST, and GGT levels were lower in iron-depleted than in control patients (P &lt; 0.05).	Iron	86-90	solute carrier family 17 member 5	Homo sapiens	52-55
24659891-11	2014	The effect of iron depletion on liver damage improvement as assessed by histology or ALT decrease &gt;= 20% was independent of baseline AST/ALT ratio and insulin resistance (P = 0.0001).	Iron	14-18	solute carrier family 17 member 5	Homo sapiens	136-139
24591593-3	2014	By repairing the BSCB and/or removing the BSCB-derived injurious stimuli, we now identify that accumulation of blood-derived neurotoxic hemoglobin and iron in the spinal cord leads to early motor-neuron degeneration in SOD1(G93A) mice at least in part through iron-dependent oxidant stress.	Iron	260-264	superoxide dismutase 1, soluble	Mus musculus	219-223
24641804-9	2014	This iron-induced apoptosis was linked to enhanced caspase 8, reduced Bcl-2, Bcl-xL, phosphorylated Akt and GATA-4.	Iron	5-9	BCL2 like 1	Homo sapiens	77-83
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	110-114	Aft2p	Saccharomyces cerevisiae S288C	62-66
24641804-9	2014	This iron-induced apoptosis was linked to enhanced caspase 8, reduced Bcl-2, Bcl-xL, phosphorylated Akt and GATA-4.	Iron	5-9	AKT serine/threonine kinase 1	Homo sapiens	100-103
24641804-11	2014	In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged.	Iron	3-7	BCL2 apoptosis regulator	Homo sapiens	138-143
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	110-114	Aft2p	Saccharomyces cerevisiae S288C	62-66
24641804-11	2014	In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged.	Iron	3-7	BCL2 like 1	Homo sapiens	145-151
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	110-114	Aft2p	Saccharomyces cerevisiae S288C	62-66
24641804-11	2014	In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged.	Iron	3-7	AKT serine/threonine kinase 1	Homo sapiens	171-174
24591629-2	2014	We present the previously unidentified crystal structure of Aft2 bound to DNA that reveals the mechanism of DNA recognition via specific interactions of the iron-responsive element with a Zn(2+)-containing WRKY-GCM1 domain in Aft2.	Iron	157-161	Aft2p	Saccharomyces cerevisiae S288C	60-64
24448401-7	2014	Elevation of SOD1 and increasing trend for iron-storage proteins (FTL, FTH1) may be indicative of an oxidative imbalance that is accompanied by an aberrant iron metabolism.	Iron	156-160	superoxide dismutase 1	Homo sapiens	13-17
24591629-2	2014	We present the previously unidentified crystal structure of Aft2 bound to DNA that reveals the mechanism of DNA recognition via specific interactions of the iron-responsive element with a Zn(2+)-containing WRKY-GCM1 domain in Aft2.	Iron	157-161	Aft2p	Saccharomyces cerevisiae S288C	226-230
24591629-6	2014	Taken together, these data provide insight into the molecular mechanism for iron-dependent transcriptional regulation of Aft2 and highlight the key role of Fe-S clusters as cellular iron signals.	Iron	76-80	Aft2p	Saccharomyces cerevisiae S288C	121-125
24591629-6	2014	Taken together, these data provide insight into the molecular mechanism for iron-dependent transcriptional regulation of Aft2 and highlight the key role of Fe-S clusters as cellular iron signals.	Iron	156-160	Aft2p	Saccharomyces cerevisiae S288C	121-125
24591629-6	2014	Taken together, these data provide insight into the molecular mechanism for iron-dependent transcriptional regulation of Aft2 and highlight the key role of Fe-S clusters as cellular iron signals.	Iron	182-186	Aft2p	Saccharomyces cerevisiae S288C	121-125
24559299-4	2014	We report that Abeta is capable of reducing ferrihydrite to a pure iron(II) mineral where antiferromagnetically ordered Fe(2+) cations occupy two nonequivalent crystal symmetry sites.	Iron	120-122	amyloid beta precursor protein	Homo sapiens	15-20
24559299-6	2014	These results demonstrate the capability of Abeta to induce the redox-active biominerals reported in AD tissue from natural iron precursors.	Iron	124-128	amyloid beta precursor protein	Homo sapiens	44-49
24653672-3	2014	These Ca(2) (+) signals, which emerge within seconds after iron addition, arise mostly from Ca(2) (+) release through the redox-sensitive ryanodine receptor (RyR) channels present in the endoplasmic reticulum.	Iron	59-63	ryanodine receptor 1	Homo sapiens	158-161
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	62-66	transferrin	Homo sapiens	102-113
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	62-66	transferrin	Homo sapiens	115-117
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	102-113
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	115-117
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	102-113
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	115-117
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	102-113
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	115-117
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	102-113
24659969-7	2014	While in normal plasma and interstitial fluids, virtually all iron is securely carried by circulating transferrin (Tf; that renders iron essentially non-labile), in systemic iron overload (IO), the total plasma iron binding capacity is often surpassed by a massive iron influx from hyperabsorptive gut or from erythrocyte overburdened spleen and/or liver.	Iron	132-136	transferrin	Homo sapiens	115-117
24659969-8	2014	As plasma Tf approaches iron saturation, labile plasma iron (LPI) emerges in forms that can infiltrate cells by unregulated routes and raise LCI to toxic levels.	Iron	55-59	transferrin	Homo sapiens	10-12
24653672-6	2014	Stimulation of RyR-mediated Ca(2) (+) release by a RyR agonist promoted mitochondrial Ca(2) (+) uptake in control neurons and in iron-treated neurons that displayed non-fragmented mitochondria, but not in neurons with fragmented mitochondria.	Iron	129-133	ryanodine receptor 1	Homo sapiens	15-18
24653672-6	2014	Stimulation of RyR-mediated Ca(2) (+) release by a RyR agonist promoted mitochondrial Ca(2) (+) uptake in control neurons and in iron-treated neurons that displayed non-fragmented mitochondria, but not in neurons with fragmented mitochondria.	Iron	129-133	ryanodine receptor 1	Homo sapiens	51-54
24653672-8	2014	Taken together, our results indicate that stimulation of redox-sensitive RyR-mediated Ca(2) (+) release by iron causes significant neuronal mitochondrial fragmentation, which presumably contributes to the impairment of neuronal function produced by iron accumulation.	Iron	107-111	ryanodine receptor 1	Homo sapiens	73-76
24653672-8	2014	Taken together, our results indicate that stimulation of redox-sensitive RyR-mediated Ca(2) (+) release by iron causes significant neuronal mitochondrial fragmentation, which presumably contributes to the impairment of neuronal function produced by iron accumulation.	Iron	249-253	ryanodine receptor 1	Homo sapiens	73-76
24480523-0	2014	Removal of As(III) and As(V) from aqueous solutions using nanoscale zero valent iron-reduced graphite oxide modified composites.	Iron	80-84	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
24480523-1	2014	Nanoscale zero valent iron (NZVI) has high adsorption capacity of As(III) and As(V), but it is limited in practical use due to its small particle size and aggregation effect.	Iron	22-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	78-83
25206866-0	2014	Baicalin suppresses iron accumulation after substantia nigra injury: relationship between iron concentration and transferrin expression.	Iron	90-94	transferrin	Rattus norvegicus	113-124
25206866-4	2014	Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins.	Iron	20-24	solute carrier family 40 member 1	Rattus norvegicus	95-108
25206866-7	2014	These results indicate that baicalin down-regulated iron concentration, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.	Iron	52-56	solute carrier family 40 member 1	Rattus norvegicus	164-177
24625978-0	2014	Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress.	Iron	114-118	tenascin R	Mus musculus	27-37
24361204-3	2014	Among these, ATP13A2 and PLA2G6 are inconsistently associated with brain iron deposition.	Iron	73-77	phospholipase A2 group VI	Homo sapiens	25-31
24653672-5	2014	Here, we describe that 24 h incubation of primary hippocampal neurons with iron enhanced agonist-induced RyR-mediated Ca(2) (+) release and promoted mitochondrial network fragmentation in 43% of neurons, a response significantly prevented by RyR inhibition and by the antioxidant agent N-acetyl-L-cysteine.	Iron	75-79	ryanodine receptor 1	Homo sapiens	105-108
24653672-5	2014	Here, we describe that 24 h incubation of primary hippocampal neurons with iron enhanced agonist-induced RyR-mediated Ca(2) (+) release and promoted mitochondrial network fragmentation in 43% of neurons, a response significantly prevented by RyR inhibition and by the antioxidant agent N-acetyl-L-cysteine.	Iron	75-79	ryanodine receptor 1	Homo sapiens	242-245
24653700-6	2014	In addition, a connection between the loss of iron homeostasis and inflammation is starting to emerge; thus, inflammatory cytokines like TNF-alpha and IL-6 induce the synthesis of the divalent metal transporter 1 and promote iron accumulation in neurons and microglia.	Iron	46-50	tumor necrosis factor	Homo sapiens	137-146
24653700-6	2014	In addition, a connection between the loss of iron homeostasis and inflammation is starting to emerge; thus, inflammatory cytokines like TNF-alpha and IL-6 induce the synthesis of the divalent metal transporter 1 and promote iron accumulation in neurons and microglia.	Iron	46-50	interleukin 6	Homo sapiens	151-155
24606901-1	2014	Iron sulfur (Fe-S) clusters, preassembled on the ISCU scaffold, are transferred to target proteins or to intermediate scaffolds by a dedicated chaperone-cochaperone system.	Iron	13-17	iron-sulfur cluster assembly enzyme	Homo sapiens	49-53
24639653-5	2014	TfR2 can bind iron-loaded transferrin (Tf) in the bloodstream, and hepatocytes treated with Tf respond with a 2-fold increase in hepcidin expression through stimulation of the bone morphogenetic protein (BMP)-signaling pathway.	Iron	14-18	transferrin	Homo sapiens	26-37
24606901-4	2014	In succinate dehydrogenase B, two LYR motifs engage the ISCU-HSC20-HSPA9 complex to aid incorporation of three Fe-S clusters within the final structure of complex II.	Iron	111-115	iron-sulfur cluster assembly enzyme	Homo sapiens	56-60
24606901-4	2014	In succinate dehydrogenase B, two LYR motifs engage the ISCU-HSC20-HSPA9 complex to aid incorporation of three Fe-S clusters within the final structure of complex II.	Iron	111-115	heat shock protein family A (Hsp70) member 9	Homo sapiens	67-72
24329121-2	2014	Induction of the peroxidase activity of cytochrome c is ascribed to partial unfolding and loss of axial co-ordination between the haem Fe and Met80, and is thought to be triggered by interaction of cytochrome c with cardiolipin (diphosphatidylglycerol) in vivo.	Iron	135-137	cytochrome c, somatic	Homo sapiens	40-52
24132807-3	2014	In the circulation, iron is transported to target organs bound to the serum iron binding protein transferrin.	Iron	20-24	transferrin	Homo sapiens	97-108
24132807-3	2014	In the circulation, iron is transported to target organs bound to the serum iron binding protein transferrin.	Iron	76-80	transferrin	Homo sapiens	97-108
24132807-4	2014	Individual cells modulate their uptake of transferrin-bound iron depending on their iron requirements, using both transferrin receptor 1-dependent and independent pathways.	Iron	60-64	transferrin	Homo sapiens	42-53
24132807-4	2014	Individual cells modulate their uptake of transferrin-bound iron depending on their iron requirements, using both transferrin receptor 1-dependent and independent pathways.	Iron	60-64	transferrin	Homo sapiens	114-125
24132807-4	2014	Individual cells modulate their uptake of transferrin-bound iron depending on their iron requirements, using both transferrin receptor 1-dependent and independent pathways.	Iron	84-88	transferrin	Homo sapiens	42-53
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	0-4	transferrin	Homo sapiens	164-175
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	35-39	transferrin	Homo sapiens	164-175
24329121-2	2014	Induction of the peroxidase activity of cytochrome c is ascribed to partial unfolding and loss of axial co-ordination between the haem Fe and Met80, and is thought to be triggered by interaction of cytochrome c with cardiolipin (diphosphatidylglycerol) in vivo.	Iron	135-137	cytochrome c, somatic	Homo sapiens	198-210
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	147-151	transferrin	Homo sapiens	164-175
24487409-0	2014	Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells.	Iron	124-128	glycosylated lysosomal membrane protein	Mus musculus	35-41
24503941-3	2014	Diagnosis of iron overload is established by elevated transferrin saturation (&gt;55%) and elevated serum ferritin (&gt;300 ng/mL).	Iron	13-17	transferrin	Homo sapiens	54-65
24059322-8	2014	The current study revealed a highly reactive narrow fissure near the non-heme iron binding pocket of 5-LOX that contains residues crucial for 5-LOX stability and FBC binding.	Iron	78-82	arachidonate 5-lipoxygenase	Homo sapiens	101-106
24059322-8	2014	The current study revealed a highly reactive narrow fissure near the non-heme iron binding pocket of 5-LOX that contains residues crucial for 5-LOX stability and FBC binding.	Iron	78-82	arachidonate 5-lipoxygenase	Homo sapiens	142-147
24487409-9	2014	In addition to collagen deposition, microscopic examination of liver sections revealed accumulation of autofluorescent lipofuscin and iron in Ncu-g1(gt/gt) Kupffer cells.	Iron	134-138	glycosylated lysosomal membrane protein	Mus musculus	142-148
24360972-7	2014	Fasting serum ferritin and transferrin-iron saturation were higher in NAFLD and were positively associated with liver fat.	Iron	39-43	transferrin	Homo sapiens	27-38
24363050-2	2014	The enhanced reductive dechlorination of PCB-contaminated soil by anaerobic composting with zero-valent iron (ZVI) was studied, and preliminary reasons for the enhanced reductive dechlorination with ZVI were investigated.	Iron	104-108	pyruvate carboxylase	Homo sapiens	41-44
24363050-2	2014	The enhanced reductive dechlorination of PCB-contaminated soil by anaerobic composting with zero-valent iron (ZVI) was studied, and preliminary reasons for the enhanced reductive dechlorination with ZVI were investigated.	Iron	110-113	pyruvate carboxylase	Homo sapiens	41-44
24363050-2	2014	The enhanced reductive dechlorination of PCB-contaminated soil by anaerobic composting with zero-valent iron (ZVI) was studied, and preliminary reasons for the enhanced reductive dechlorination with ZVI were investigated.	Iron	199-202	pyruvate carboxylase	Homo sapiens	41-44
24373749-6	2014	Thereafter, up-regulation of hepcidin, a central regulator of systemic iron homeostasis, was observed in hepatocytes on day 2.	Iron	71-75	hepcidin antimicrobial peptide	Rattus norvegicus	29-37
24373749-11	2014	Our results suggest that IL6 released by portal macrophages may regulate hepatocyte hepcidin expression via STAT3 activation during transient iron overload in TAA-induced acute liver injury.	Iron	142-146	interleukin 6	Rattus norvegicus	25-28
24373749-11	2014	Our results suggest that IL6 released by portal macrophages may regulate hepatocyte hepcidin expression via STAT3 activation during transient iron overload in TAA-induced acute liver injury.	Iron	142-146	hepcidin antimicrobial peptide	Rattus norvegicus	84-92
24571258-0	2014	Lactoferrin gene knockdown leads to similar effects to iron chelation in human adipocytes.	Iron	55-59	lactotransferrin	Homo sapiens	0-11
24241495-3	2014	Endotoxemia resulted in an initial increase in serum iron levels and transferrin saturation that was accompanied by an increase in labile plasma iron, especially when transferrin saturation reached levels above 90%.	Iron	145-149	transferrin	Homo sapiens	167-178
24554823-2	2014	Congenital dyserythropoietic anemia type I (CDA I) is an autosomal recessive disorder with ineffective erythropoiesis and iron overloading.	Iron	122-126	codanin 1	Homo sapiens	0-42
24554823-2	2014	Congenital dyserythropoietic anemia type I (CDA I) is an autosomal recessive disorder with ineffective erythropoiesis and iron overloading.	Iron	122-126	codanin 1	Homo sapiens	44-49
24420575-5	2014	The transcript levels of NtIRT1 and NtZIP1 were higher in transgenic plants, indicating an induction of the Fe and Zn deficiency status due to AtHMA4 expression.	Iron	108-110	zinc transporter 5-like	Nicotiana tabacum	36-42
24401818-9	2014	Both transferrin saturation and serum iron were inversely related to CHD incidence [RR (95% CI): 0.76 (0.66, 0.88) and 0.68 (0.56, 0.82), respectively], but only transferrin saturation was inversely associated with CHD mortality (RR: 0.85; 95% CI: 0.73, 0.99).	Iron	38-42	transferrin	Homo sapiens	162-173
24804175-12	2014	A link between excess body iron and insulin resistance or the metabolic syndrome has become apparent.	Iron	27-31	insulin	Homo sapiens	36-43
25286591-4	2014	The importance of the study of haptoglobin due to its involvement in the metabolism of hemoglobin and transferrin--the exchange of iron.	Iron	131-135	transferrin	Homo sapiens	102-113
24142530-0	2014	High expression of APAF-1 elevates erythroid apoptosis in iron overload myelodysplastic syndrome.	Iron	58-62	apoptotic peptidase activating factor 1	Homo sapiens	19-25
24456400-8	2014	In particular, the transcription levels of FIT, IRT1 and FRO2 were reduced in the yid1 and med25 mutants under iron-deficient conditions.	Iron	111-115	phytochrome and flowering time regulatory protein (PFT1)	Arabidopsis thaliana	91-96
24456400-9	2014	The finding that YID1/MED16 and MED25 positively regulate iron homeostasis in Arabidopsis increases our understanding of the complex transcriptional regulation of iron homeostasis in plants.	Iron	58-62	phytochrome and flowering time regulatory protein (PFT1)	Arabidopsis thaliana	32-37
24456400-9	2014	The finding that YID1/MED16 and MED25 positively regulate iron homeostasis in Arabidopsis increases our understanding of the complex transcriptional regulation of iron homeostasis in plants.	Iron	163-167	phytochrome and flowering time regulatory protein (PFT1)	Arabidopsis thaliana	32-37
24142530-6	2014	Both erythroid apoptosis rate and APAF-1 mRNA expression of the iron overload (IO) group were significantly higher than those of the non-IO group (P &lt; 0.001 and P &lt; 0.001).	Iron	64-68	apoptotic peptidase activating factor 1	Homo sapiens	34-40
24142530-10	2014	APAF-1 plays an important role in iron-induced erythroid apoptosis increase in MDS.	Iron	34-38	apoptotic peptidase activating factor 1	Homo sapiens	0-6
24421313-1	2014	Yeast cells deficient in the Rieske iron-sulfur subunit (Rip1) of ubiquinol-cytochrome c reductase (bc1) accumulate a late core assembly intermediate, which weakly associates with cytochrome oxidase (CcO) in a respiratory supercomplex.	Iron	36-40	ubiquinol--cytochrome-c reductase catalytic subunit RIP1	Saccharomyces cerevisiae S288C	57-61
24764731-0	2014	The impact of obesity and insulin resistance on iron and red blood cell parameters: a single center, cross-sectional study.	Iron	48-52	insulin	Homo sapiens	26-33
24577088-2	2014	MicroRNA-210 (miR-210) is regulated by hypoxia-inducible transcription factor-1alpha (HIF-1alpha) under hypoxic conditions and controls mitochondrial energy metabolism by repressing the iron-sulfur cluster assembly protein (ISCU1/2).	Iron	186-190	microRNA 210	Mus musculus	0-12
24576354-2	2014	Previous laboratory and clinical studies have shown that IL-6 causes a significant decrease in serum iron levels.	Iron	101-105	interleukin 6	Homo sapiens	57-61
24576354-3	2014	Therefore, we conducted an epidemiological study to examine the association between serum IL-6 and iron levels.	Iron	99-103	interleukin 6	Homo sapiens	90-94
24576354-8	2014	The logarithm of serum iron levels was negatively correlated with the logarithm of IL-6 levels in men (r = -0.19, p = 0.047), but not in women (r = -0.035, p = 0.65).	Iron	23-27	interleukin 6	Homo sapiens	83-87
24576354-9	2014	Regression analysis, adjusted for sex, age, and H. pylori infection status, showed that the logarithm of serum iron levels was significantly associated with a decreased logarithm of IL-6 levels (beta = -0.053, p = 0.041).	Iron	111-115	interleukin 6	Homo sapiens	182-186
24576354-10	2014	The odds ratio for low serum iron levels adjusted for sex, age, and H. pylori infection status was 7.88 (95% CI 1.29-48.06) in those with an IL-6 level &gt; 4 pg/mL.	Iron	29-33	interleukin 6	Homo sapiens	141-145
24576354-11	2014	CONCLUSION: Lower serum iron levels are significantly associated with higher serum IL-6 levels among Japanese adults.	Iron	24-28	interleukin 6	Homo sapiens	83-87
24577088-2	2014	MicroRNA-210 (miR-210) is regulated by hypoxia-inducible transcription factor-1alpha (HIF-1alpha) under hypoxic conditions and controls mitochondrial energy metabolism by repressing the iron-sulfur cluster assembly protein (ISCU1/2).	Iron	186-190	microRNA 210	Mus musculus	14-21
24616700-1	2014	In iron overload disorders a significant fraction of the total iron circulates in the plasma as low molecular weight complexes not bound to transferrin, known as non-transferrin-bound iron (NTBI).	Iron	63-67	transferrin	Homo sapiens	166-177
24586826-10	2014	NGAL stimulated expression of HLA-G on CD4+ T cells in a dose- and iron-dependent manner.	Iron	67-71	CD4 molecule	Homo sapiens	39-42
24616700-1	2014	In iron overload disorders a significant fraction of the total iron circulates in the plasma as low molecular weight complexes not bound to transferrin, known as non-transferrin-bound iron (NTBI).	Iron	63-67	transferrin	Homo sapiens	166-177
24586648-11	2014	Our data show that ferritin H is required for B and T cell survival by actively reducing the labile iron pool.	Iron	100-104	ferritin mitochondrial	Mus musculus	19-29
24574031-1	2014	The reaction of fac-[M(III)F3(Me3tacn)] x H2O with Gd(NO3)3 5H2O affords a series of fluoride-bridged, trigonal bipyramidal {Gd(III)3M(III)2} (M = Cr (1), Fe (2), Ga (3)) complexes without signs of concomitant GdF3 formation, thereby demonstrating the applicability even of labile fluoride-complexes as precursors for 3d-4f systems.	Iron	155-157	FA complementation group C	Homo sapiens	16-19
27335844-0	2014	Improved Serum Alpha-Fetoprotein Levels after Iron Reduction Therapy in HCV Patients.	Iron	46-50	alpha fetoprotein	Homo sapiens	15-32
24357729-2	2014	Induction of hepcidin, mediated by interleukin 6, leads to iron-restricted erythropoiesis and anemia.	Iron	59-63	interleukin 6	Mus musculus	35-48
24291744-9	2014	Third, trpm7 mutants are unusually sensitive to the neurotoxin 1-methyl-4-phenylpyridinium, an oxidative stressor, and their motility is partially rescued by application of the iron chelator deferoxamine, an anti-oxidant.	Iron	177-181	transient receptor potential cation channel, subfamily M, member 7	Danio rerio	7-12
24357718-5	2014	Treatment with TNFalpha induces the translocation of a Stat3-Grim-19 complex to the mitochondria, which binds to mitoneet and promotes the rapid release of its 2Fe-2S cluster, causing an accumulation of mitochondrial iron.	Iron	217-221	tumor necrosis factor	Mus musculus	15-23
24357718-5	2014	Treatment with TNFalpha induces the translocation of a Stat3-Grim-19 complex to the mitochondria, which binds to mitoneet and promotes the rapid release of its 2Fe-2S cluster, causing an accumulation of mitochondrial iron.	Iron	217-221	CDGSH iron sulfur domain 1	Mus musculus	113-121
24375408-9	2014	In addition to monovalent cations, TRPML exhibits high permeability to Ca(2+), Mn(2+), and Fe(2+), but not Fe(3+).	Iron	91-93	Transient receptor potential cation channel, mucolipin	Drosophila melanogaster	35-40
24505281-2	2014	However, little is known about the impact of transferrin saturation (TSAT), a marker reflecting the availability of iron for erythropoiesis, on clinical outcome in dialysis patients.	Iron	116-120	transferrin	Homo sapiens	45-56
24211262-0	2014	Potential problems in the determination of serum non-transferrin-bound iron using nitrilotriacetic acid and ultrafiltration.	Iron	71-75	transferrin	Homo sapiens	53-64
27335844-2	2014	To examine the changes in serum alpha-fetoprotein (AFP) levels after iron reduction by therapeutic phlebotomy in chronic hepatitis C patients.	Iron	69-73	alpha fetoprotein	Homo sapiens	32-49
27335844-2	2014	To examine the changes in serum alpha-fetoprotein (AFP) levels after iron reduction by therapeutic phlebotomy in chronic hepatitis C patients.	Iron	69-73	alpha fetoprotein	Homo sapiens	51-54
27335844-7	2014	Iron reduction therapy significantly reduced the median level of serum AFP from 13 to 7 ng/mL, ALT from 96 to 50 IU/L, gamma-glutamyl transpeptidase (GGT) from 55 to 28 IU/L, and ferritin from 191 to 10 ng/mL (P &lt; 0.001 for each).	Iron	0-4	alpha fetoprotein	Homo sapiens	71-74
27335844-13	2014	Iron reduction by therapeutic phlebotomy can reduce serum AFP and GGT levels in chronic hepatitis C patients.	Iron	0-4	alpha fetoprotein	Homo sapiens	58-61
24346829-7	2014	Normalization of Fe-induced oxidative stress status occurred concomitantly with that of Nrf2 and with the Nrf2-dependent HO-1 and NQO-1 expression, which are associated with delayed enhancement in cytosolic Keap1 levels.	Iron	17-19	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	130-135
24535840-4	2014	Folate and vitamin B12 status have important links to iron metabolism.	Iron	54-58	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
24567965-0	2014	Haptoglobin and myeloperoxidase (- G463A) gene polymorphisms in Brazilian sickle cell patients with and without secondary iron overload.	Iron	122-126	myeloperoxidase	Homo sapiens	16-31
24231192-11	2014	In conclusion, these results deepen our knowledge of the protective action of MET against DOX-induced cardiotoxicity and suggest that therapeutic strategies based on FHC modulation could protect cardiomyocytes from the mitochondrial damage induced by DOX by restoring iron homeostasis.	Iron	268-272	ferritin heavy chain 1	Rattus norvegicus	166-169
23907767-0	2014	Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin.	Iron	31-35	epidermal growth factor receptor	Homo sapiens	66-98
24119518-3	2014	The IL-6-hepcidin antimicrobial peptide axis promotes iron-restricted anemia; however the full role of IL-6 in anemia of inflammation is not well-defined.	Iron	54-58	interleukin 6	Homo sapiens	4-8
24359498-8	2014	The present findings indicate that the multifunctional iron chelating drug, M30 regulates major brain glucose metabolism parameters and thus, might be beneficial for AD, in which impaired neuronal insulin signaling and Glut expression have been implicated.	Iron	55-59	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	219-223
24374092-7	2014	Lowest plasma IL-12 and interferon-gamma concentrations were observed in iron-deficient mice with aneuploidy.	Iron	73-77	interferon gamma	Mus musculus	24-40
24346829-0	2014	Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol.	Iron	80-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
24346829-1	2014	Sub-chronic iron (Fe) administration induces liver oxidative stress upregulating cytoprotective mechanisms that may involve redox-sensitive nuclear factor erythroid 2-related factor 2 (Nrf2).	Iron	12-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-183
24346829-1	2014	Sub-chronic iron (Fe) administration induces liver oxidative stress upregulating cytoprotective mechanisms that may involve redox-sensitive nuclear factor erythroid 2-related factor 2 (Nrf2).	Iron	12-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	185-189
24346829-1	2014	Sub-chronic iron (Fe) administration induces liver oxidative stress upregulating cytoprotective mechanisms that may involve redox-sensitive nuclear factor erythroid 2-related factor 2 (Nrf2).	Iron	18-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-183
24346829-1	2014	Sub-chronic iron (Fe) administration induces liver oxidative stress upregulating cytoprotective mechanisms that may involve redox-sensitive nuclear factor erythroid 2-related factor 2 (Nrf2).	Iron	18-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	185-189
24346829-2	2014	We aimed to investigate whether Fe activates Nrf2, in relation to its negative regulator Kelch-like ECH associated protein 1 (Keap1), with consequent antioxidant enzyme induction.	Iron	32-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	45-49
23907767-7	2014	These findings suggest that novel therapeutic strategies targeting the testosterone/EGF/EGFR axis may be useful for inducing hepcidin expression in patients with iron overload and/or chronic liver diseases.	Iron	162-166	epidermal growth factor receptor	Homo sapiens	88-92
24346829-9	2014	In conclusion, sub-chronic Fe administration leads to transient liver oxidative stress development and Nrf2 activation, as evidenced by early GSH depletion, enhanced nuclear Nrf2 protein levels, and HO-1 and NQO-1 induction, with late normalization of these changes being related to Keap1 upregulation.	Iron	27-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-107
24346829-5	2014	Increased hepatic Fe deposition (Perls staining) was paralleled by reversible GSH depletion and enhancements in nuclear Nrf2 content and in nuclear/cytosolic Nrf2 ratios.	Iron	18-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	158-162
24346829-9	2014	In conclusion, sub-chronic Fe administration leads to transient liver oxidative stress development and Nrf2 activation, as evidenced by early GSH depletion, enhanced nuclear Nrf2 protein levels, and HO-1 and NQO-1 induction, with late normalization of these changes being related to Keap1 upregulation.	Iron	27-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	174-178
24346829-7	2014	Normalization of Fe-induced oxidative stress status occurred concomitantly with that of Nrf2 and with the Nrf2-dependent HO-1 and NQO-1 expression, which are associated with delayed enhancement in cytosolic Keap1 levels.	Iron	17-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
24346829-9	2014	In conclusion, sub-chronic Fe administration leads to transient liver oxidative stress development and Nrf2 activation, as evidenced by early GSH depletion, enhanced nuclear Nrf2 protein levels, and HO-1 and NQO-1 induction, with late normalization of these changes being related to Keap1 upregulation.	Iron	27-29	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	208-213
24346829-7	2014	Normalization of Fe-induced oxidative stress status occurred concomitantly with that of Nrf2 and with the Nrf2-dependent HO-1 and NQO-1 expression, which are associated with delayed enhancement in cytosolic Keap1 levels.	Iron	17-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
23926964-2	2014	Iron dysregulation has been reported during treatment with IFN; however, it remains unclear whether IFN itself affects iron metabolism.	Iron	0-4	interferon alpha 1	Homo sapiens	59-62
23873717-9	2014	Iron-deficient mice also showed increased Cyp24a1 and reduced Cyp27b1, and low serum 1,25-dihydroxyvitamin D (1,25D).	Iron	0-4	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	62-69
23731862-1	2014	INTRODUCTION: The aim of this study was to establish the sensitivity and specificity of the microcytic anemia factor (Maf( )), which is generated by the Coulter LH 750 analyzer in the evaluation of iron depletion and iron-deficient erythropoiesis in athletes.	Iron	198-202	MAF bZIP transcription factor	Homo sapiens	92-116
23731862-1	2014	INTRODUCTION: The aim of this study was to establish the sensitivity and specificity of the microcytic anemia factor (Maf( )), which is generated by the Coulter LH 750 analyzer in the evaluation of iron depletion and iron-deficient erythropoiesis in athletes.	Iron	198-202	MAF bZIP transcription factor	Homo sapiens	118-121
23731862-4	2014	RESULTS: The best Maf( ) value to exclude iron depletion in athletes was 130.3, showing a sensitivity of 72.6% and a specificity of 57.3%.	Iron	42-46	MAF bZIP transcription factor	Homo sapiens	18-21
23731862-8	2014	Also, in cost/benefit terms, monitoring of Maf( ) is justified as a low cost, effective screening parameter for determining iron status in athletes.	Iron	124-128	MAF bZIP transcription factor	Homo sapiens	43-46
23926964-3	2014	We therefore determined the effect of IFN on iron metabolism.	Iron	45-49	interferon alpha 1	Homo sapiens	38-41
23926964-11	2014	CONCLUSIONS: Results indicate that iron absorption is decreased during IFN treatment; this favorable effect could inhibit iron overload during IFN treatment and may enhance the action of IFN.	Iron	35-39	interferon alpha 1	Homo sapiens	71-74
23926964-11	2014	CONCLUSIONS: Results indicate that iron absorption is decreased during IFN treatment; this favorable effect could inhibit iron overload during IFN treatment and may enhance the action of IFN.	Iron	35-39	interferon alpha 1	Homo sapiens	143-146
23926964-11	2014	CONCLUSIONS: Results indicate that iron absorption is decreased during IFN treatment; this favorable effect could inhibit iron overload during IFN treatment and may enhance the action of IFN.	Iron	35-39	interferon alpha 1	Homo sapiens	143-146
24021424-0	2014	Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death.	Iron	56-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
23926964-11	2014	CONCLUSIONS: Results indicate that iron absorption is decreased during IFN treatment; this favorable effect could inhibit iron overload during IFN treatment and may enhance the action of IFN.	Iron	122-126	interferon alpha 1	Homo sapiens	71-74
24021424-3	2014	We aimed to determine if the NRF2 pathway plays a significant role in the protection against hepatic iron overload.	Iron	101-105	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
24021424-6	2014	RESULTS: In mouse hepatocytes, iron induced the nuclear translocation of NRF2 and the expression of cytoprotective genes in an NRF2-dependent manner.	Iron	31-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
23926964-11	2014	CONCLUSIONS: Results indicate that iron absorption is decreased during IFN treatment; this favorable effect could inhibit iron overload during IFN treatment and may enhance the action of IFN.	Iron	122-126	interferon alpha 1	Homo sapiens	143-146
24021424-6	2014	RESULTS: In mouse hepatocytes, iron induced the nuclear translocation of NRF2 and the expression of cytoprotective genes in an NRF2-dependent manner.	Iron	31-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
24021424-7	2014	Moreover, Nrf2(-/-) hepatocytes were highly susceptible to iron-induced cell death.	Iron	59-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	10-14
23926964-11	2014	CONCLUSIONS: Results indicate that iron absorption is decreased during IFN treatment; this favorable effect could inhibit iron overload during IFN treatment and may enhance the action of IFN.	Iron	122-126	interferon alpha 1	Homo sapiens	143-146
24021424-8	2014	Wild-type and Nrf2(-/-) mice fed iron-rich diet accumulated similar amounts of iron in the liver and were equally able to increase the expression of hepatic hepcidin and ferritin.	Iron	33-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
24176079-4	2014	Trans-placental iron transfer involves binding transferrin (Tf)-bound iron to the Tf receptor, uptake into an endosome, acidification, release of iron through divalent metal transporter 1, efflux across the basolateral membrane through ferroportin and oxidation of Fe(II) by zyklopen.	Iron	70-74	transferrin	Homo sapiens	47-58
24021424-9	2014	Nevertheless, in Nrf2-null mice the iron loading resulted in progressive liver injury, ranging from mild confluent necrosis to severe necroinflammatory lesions.	Iron	36-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
24021424-12	2014	CONCLUSIONS: NRF2 protects the mouse liver against the toxicity of dietary iron overload by preventing hepatocytic cell death.	Iron	75-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
24021424-13	2014	We identify NRF2 as a potential modifier of liver disease in iron overload pathology and show the beneficial effect of the antioxidant mito-TEMPOL in a mouse model of dietary iron-induced liver injury.	Iron	61-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	12-16
24372300-1	2014	OBJECTIVE: To investigate the iron status, its relationship with C-reactive protein and the prognostic value of both in canine leishmaniasis.	Iron	30-34	C-reactive protein	Canis lupus familiaris	65-83
24372300-9	2014	There was a significant but low correlation of C-reactive protein with iron, ferritin and total iron-binding capacity.	Iron	71-75	C-reactive protein	Canis lupus familiaris	47-65
24372300-9	2014	There was a significant but low correlation of C-reactive protein with iron, ferritin and total iron-binding capacity.	Iron	96-100	C-reactive protein	Canis lupus familiaris	47-65
24121126-0	2014	Pooled analysis of iron-related genes in Parkinson"s disease: association with transferrin.	Iron	19-23	transferrin	Homo sapiens	79-90
24121126-8	2014	Taken together with previous findings in model systems, our results suggest that TF or a TF-TFR2 complex may have a role in the etiology of PD, possibly through iron misregulation or mitochondrial dysfunction within dopaminergic neurons.	Iron	161-165	transferrin	Homo sapiens	81-83
24121126-8	2014	Taken together with previous findings in model systems, our results suggest that TF or a TF-TFR2 complex may have a role in the etiology of PD, possibly through iron misregulation or mitochondrial dysfunction within dopaminergic neurons.	Iron	161-165	transferrin	Homo sapiens	89-91
24649744-5	2014	Only a minute amount (3-4 mg) of the total body iron (3-4 g in an adult man) resides in the plasma bound to transferrin, which serves as a safe vehicle for iron transport in the circulation.	Iron	48-52	transferrin	Homo sapiens	108-119
24649744-5	2014	Only a minute amount (3-4 mg) of the total body iron (3-4 g in an adult man) resides in the plasma bound to transferrin, which serves as a safe vehicle for iron transport in the circulation.	Iron	156-160	transferrin	Homo sapiens	108-119
24649744-7	2014	Administration of these products results in an increased plasma level of catalytically active non-transferrin bound iron and the rise in the biomarkers of oxidative stress and inflammation.	Iron	116-120	transferrin	Homo sapiens	98-109
24176079-4	2014	Trans-placental iron transfer involves binding transferrin (Tf)-bound iron to the Tf receptor, uptake into an endosome, acidification, release of iron through divalent metal transporter 1, efflux across the basolateral membrane through ferroportin and oxidation of Fe(II) by zyklopen.	Iron	16-20	transferrin	Homo sapiens	47-58
24176079-4	2014	Trans-placental iron transfer involves binding transferrin (Tf)-bound iron to the Tf receptor, uptake into an endosome, acidification, release of iron through divalent metal transporter 1, efflux across the basolateral membrane through ferroportin and oxidation of Fe(II) by zyklopen.	Iron	16-20	transferrin	Homo sapiens	60-62
24176079-4	2014	Trans-placental iron transfer involves binding transferrin (Tf)-bound iron to the Tf receptor, uptake into an endosome, acidification, release of iron through divalent metal transporter 1, efflux across the basolateral membrane through ferroportin and oxidation of Fe(II) by zyklopen.	Iron	70-74	transferrin	Homo sapiens	47-58
24176079-4	2014	Trans-placental iron transfer involves binding transferrin (Tf)-bound iron to the Tf receptor, uptake into an endosome, acidification, release of iron through divalent metal transporter 1, efflux across the basolateral membrane through ferroportin and oxidation of Fe(II) by zyklopen.	Iron	70-74	transferrin	Homo sapiens	60-62
24176079-4	2014	Trans-placental iron transfer involves binding transferrin (Tf)-bound iron to the Tf receptor, uptake into an endosome, acidification, release of iron through divalent metal transporter 1, efflux across the basolateral membrane through ferroportin and oxidation of Fe(II) by zyklopen.	Iron	70-74	transferrin	Homo sapiens	60-62
24454764-3	2014	Here, we used conditional knockout mice for the iron exporter ferroportin1 (Fpn1) to modulate tissue iron in specific tissues in combination with iron-deficient or iron-rich diets and transferrin (Tf) supplementation to investigate the mechanisms underlying Hamp1 expression.	Iron	48-52	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	62-74
24397846-3	2014	Iron chelation therapy could be a viable strategy to block iron-related pathological events or it can confer cellular protection by stabilizing hypoxia inducible factor 1alpha, a transcription factor that normally responds to hypoxic conditions.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-175
24498236-1	2014	BACKGROUND: In the liver, bone morphogenetic protein 6 (BMP-6) maintains balanced iron metabolism.	Iron	82-86	bone morphogenetic protein 6	Homo sapiens	26-54
24498236-1	2014	BACKGROUND: In the liver, bone morphogenetic protein 6 (BMP-6) maintains balanced iron metabolism.	Iron	82-86	bone morphogenetic protein 6	Homo sapiens	56-61
24285726-3	2014	Here, we demonstrate that iron regulatory protein 2 (IRP2) plays a key role in iron accumulation in breast cancer.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	53-57
24285726-5	2014	Knockdown of IRP2 in triple-negative MDA-MB-231 human breast cancer cells increases ferritin H expression and decreases TfR1 expression, resulting in a decrease in the labile iron pool.	Iron	175-179	iron responsive element binding protein 2	Homo sapiens	13-17
24285726-9	2014	These results suggest that dysregulation of IRP2 is an early nodal point underlying altered iron metabolism in breast cancer and may contribute to poor outcome of some patients with breast cancer.	Iron	92-96	iron responsive element binding protein 2	Homo sapiens	44-48
24454764-3	2014	Here, we used conditional knockout mice for the iron exporter ferroportin1 (Fpn1) to modulate tissue iron in specific tissues in combination with iron-deficient or iron-rich diets and transferrin (Tf) supplementation to investigate the mechanisms underlying Hamp1 expression.	Iron	48-52	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	76-80
24454764-3	2014	Here, we used conditional knockout mice for the iron exporter ferroportin1 (Fpn1) to modulate tissue iron in specific tissues in combination with iron-deficient or iron-rich diets and transferrin (Tf) supplementation to investigate the mechanisms underlying Hamp1 expression.	Iron	101-105	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	62-74
24454764-3	2014	Here, we used conditional knockout mice for the iron exporter ferroportin1 (Fpn1) to modulate tissue iron in specific tissues in combination with iron-deficient or iron-rich diets and transferrin (Tf) supplementation to investigate the mechanisms underlying Hamp1 expression.	Iron	101-105	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	76-80
24454764-3	2014	Here, we used conditional knockout mice for the iron exporter ferroportin1 (Fpn1) to modulate tissue iron in specific tissues in combination with iron-deficient or iron-rich diets and transferrin (Tf) supplementation to investigate the mechanisms underlying Hamp1 expression.	Iron	101-105	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	62-74
24454764-3	2014	Here, we used conditional knockout mice for the iron exporter ferroportin1 (Fpn1) to modulate tissue iron in specific tissues in combination with iron-deficient or iron-rich diets and transferrin (Tf) supplementation to investigate the mechanisms underlying Hamp1 expression.	Iron	101-105	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	76-80
25347084-12	2014	Our findings suggest that Pon1 interacts with diverse cellular processes - from lipoprotein metabolism, nitric oxide regulation, and energy metabolism to iron transport and antioxidant defenses - that are essential for normal liver homeostasis and modulation of these interactions by a high-methionine diet may contribute to fatty liver disease.	Iron	154-158	paraoxonase 1	Mus musculus	26-30
24402196-5	2014	Two kinds of tdap iron complexes, namely [Fe(tdap)2(NCS)2] and [Fe(tdap)2(NCS)2] MeCN exhibited spin crossover transitions, and their transition temperatures showed a difference of 150 K, despite their similar molecular structures.	Iron	18-22	cytosolic thiouridylase subunit 2	Homo sapiens	52-57
24402196-5	2014	Two kinds of tdap iron complexes, namely [Fe(tdap)2(NCS)2] and [Fe(tdap)2(NCS)2] MeCN exhibited spin crossover transitions, and their transition temperatures showed a difference of 150 K, despite their similar molecular structures.	Iron	18-22	cytosolic thiouridylase subunit 2	Homo sapiens	74-79
24383984-0	2014	Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.	Iron	26-30	S100 calcium binding protein B	Homo sapiens	11-14
24383984-0	2014	Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.	Iron	26-30	transferrin	Homo sapiens	88-99
24383984-3	2014	Here, we evaluated the effect on cellular iron uptake upon expression of the accessory protein Nef from different lentiviral strains.	Iron	42-46	S100 calcium binding protein B	Homo sapiens	95-98
24383984-6	2014	Importantly, SIV Nef-induced inhibition of TfR endocytosis leads to the reduction of Transferrin uptake and intracellular iron concentration and is accompanied by attenuated lentiviral replication in macrophages.	Iron	122-126	S100 calcium binding protein B	Homo sapiens	17-20
24383984-7	2014	CONCLUSION: Inhibition of Transferrin and thereby iron uptake by SIV Nef might limit viral replication in myeloid cells.	Iron	50-54	transferrin	Homo sapiens	26-37
24383984-7	2014	CONCLUSION: Inhibition of Transferrin and thereby iron uptake by SIV Nef might limit viral replication in myeloid cells.	Iron	50-54	S100 calcium binding protein B	Homo sapiens	69-72
24294939-2	2014	It has been reported that EPO can stimulate intestinal iron absorption.	Iron	55-59	erythropoietin	Homo sapiens	26-29
24394537-0	2014	Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2alpha.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	86-90
24394537-7	2014	Ascorbate-induced up-regulation of cellular ferroportin levels (no added iron) was associated with increased levels of the iron regulatory protein IRP2 (230%, p=0.0009), and the hypoxia-inducible factor HIF2alpha (69%, p=0.03).	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	147-151
24394537-8	2014	Thus, iron transport across the basal border via ferroportin is influenced by the intracellular status of ascorbate and IRP2 and HIF2alpha are involved.	Iron	6-10	iron responsive element binding protein 2	Homo sapiens	120-124
25347084-7	2014	In animals fed with a control diet, the expression of three liver proteins involved in lipoprotein metabolism (ApoE), iron metabolism (Ftl), and regulation of nitric oxide generation (Ddah1) was up-regulated by the Pon1(-/-) genotype.	Iron	118-122	paraoxonase 1	Mus musculus	215-219
24513913-7	2014	In the analyses of the study arms, intravenous iron therapy resulted in a significant increase in hemoglobin, serum ferritin, transferrin saturation rate, serum iron, reticulocyte hemoglobin content as well as a significant decrease in the percentage of hypochromic erythrocytes and erythropoietin dose.	Iron	47-51	transferrin	Homo sapiens	126-137
24513913-7	2014	In the analyses of the study arms, intravenous iron therapy resulted in a significant increase in hemoglobin, serum ferritin, transferrin saturation rate, serum iron, reticulocyte hemoglobin content as well as a significant decrease in the percentage of hypochromic erythrocytes and erythropoietin dose.	Iron	47-51	erythropoietin	Homo sapiens	283-297
23993269-2	2014	Since dysregulation of the iron regulatory hormone, hepcidin, can cause iron accumulation, our goal was to characterize the regulation of hepcidin in young (6 mo) and old (24 mo) Fischer 344 rats exposed to environmental heat stress.	Iron	72-76	hepcidin antimicrobial peptide	Rattus norvegicus	52-60
24995692-3	2014	Specifically, BMP6 serves to relate hepatic iron stores to the hepatocellular expression of the iron-regulatory hormone hepcidin.	Iron	44-48	bone morphogenetic protein 6	Homo sapiens	14-18
24161166-3	2014	Deferoxamine mesylate (DFO) is an FDA-approved iron chelator which has been shown to upregulate cellular HIF-1alpha.	Iron	47-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
24142518-2	2014	In this study we investigated the hypothesis that exposure of human alveolar epithelial cells to hemoglobin and its breakdown products regulates chemokine release via iron- and oxidant-mediated activation of the transcription factor NF-kappaB.	Iron	167-171	nuclear factor kappa B subunit 1	Homo sapiens	233-242
24974683-0	2014	Haptoglobin 2-2 phenotype is associated with decreased serum iron levels in endstage renal disease patients resistant to rhEPO therapy.	Iron	61-65	haptoglobin	Homo sapiens	0-11
24293384-10	2014	Moreover, positive correlations between serum insulin and iron in the liver, between TNF alpha and iron in the liver, and between TNF alpha and copper in the heart were observed.	Iron	99-103	tumor necrosis factor	Rattus norvegicus	85-94
25580431-4	2014	Serum iron was increased and associated with mRNA overexpression of hepatic hepcidin and other iron regulatory mediators and downregulation of matriptase-2; overexpression of divalent metal transporter 1 and ferroportin was observed in duodenum and liver.	Iron	6-10	transmembrane serine protease 6	Homo sapiens	143-155
24246481-3	2014	Results obtained demonstrated a sound performance of synergistic denitrification and chemical precipitation in pre-denitrification of the modified BAF process when dosing Fe salts, which showed enhanced by using Fe(2+) as the dosed precipitant in increasing the denitrification loading rate, exhibiting a better controlling of the residual phosphorus in pre-denitrification effluent, and improving sludge settleability.	Iron	171-173	BAF nuclear assembly factor 1	Homo sapiens	147-150
24300585-6	2014	Removal of anionic contaminants (As(V) and P) was likely controlled by electrostatic attraction with the iron particles on the BBCF surfaces.	Iron	105-109	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-38
25039779-4	2014	Currently, the iron-binding protein transferrin or antibodies raised against the transferrin receptor denote the most feasible molecule for targeting purposes at the BBB.	Iron	15-19	transferrin	Homo sapiens	36-47
24401606-1	2014	BACKGROUND: Heme oxygenase-1 (HO-1), which is suggested to play a role in defending the organism against oxidative stress-mediated injuries, can be induced by diverse factors including viruses and iron.	Iron	197-201	heme oxygenase 1	Mus musculus	30-34
24401606-4	2014	HO-1, which is also expressed in cultivated RAW 264.7 macrophages upon incubation with iron and/or CVB3, could be downregulated by inhibition of NO/iNOS using L-NAME.	Iron	87-91	heme oxygenase 1	Mus musculus	0-4
24401606-5	2014	Moreover, specific inhibition of HO-1 by tin mesoporphyrin revealed a suppression of superoxide production in iron and/or CVB3-treated macrophages.	Iron	110-114	heme oxygenase 1	Mus musculus	33-37
24401606-6	2014	The molecular relationship of HO-1 and caspase-3 activation was proven by downregulation with HO-1 siRNA in iron- and/or CVB3-treated cultivated cells.	Iron	108-112	heme oxygenase 1	Mus musculus	30-34
24401606-6	2014	The molecular relationship of HO-1 and caspase-3 activation was proven by downregulation with HO-1 siRNA in iron- and/or CVB3-treated cultivated cells.	Iron	108-112	heme oxygenase 1	Mus musculus	94-98
24401606-9	2014	Notably, in genetically susceptible mice iron potentiates the detrimental effects of CVB3 by the NO/HO-1 pathway, thus increasing cardiac pathogenicity.	Iron	41-45	heme oxygenase 1	Mus musculus	100-104
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	78-82	transferrin	Homo sapiens	173-184
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	78-82	transferrin	Homo sapiens	250-261
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	transferrin	Homo sapiens	173-184
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	transferrin	Homo sapiens	250-261
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	transferrin	Homo sapiens	173-184
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	transferrin	Homo sapiens	250-261
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	transferrin	Homo sapiens	173-184
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	transferrin	Homo sapiens	250-261
24732598-1	2014	BACKGROUND/AIM: Deferoxamine (DFO), an iron chelator, has been reported to induce hypoxia-inducible factor-1alpha (HIF-1alpha) expression.	Iron	39-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-113
24732598-1	2014	BACKGROUND/AIM: Deferoxamine (DFO), an iron chelator, has been reported to induce hypoxia-inducible factor-1alpha (HIF-1alpha) expression.	Iron	39-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
25074643-2	2014	Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR).	Iron	33-37	epidermal growth factor receptor	Homo sapiens	125-129
24460061-4	2014	In this paper, we study the kinetics of As(V) sorption over  3000 h in nine systems with varying pH and As(V)/Fe.	Iron	110-112	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-45
24460061-6	2014	A stable [As(V)] was only observed in systems with low As(V)/Fe and low pH.	Iron	61-63	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-15
24473150-0	2014	Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro.	Iron	18-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-69
24141093-3	2014	(59)Fe was released from spleen and liver beginning on day 2 and day 5 after ferritin-H deletion, respectively, but was not excreted from the body.	Iron	4-6	ferritin mitochondrial	Mus musculus	77-87
23943793-0	2014	Elevated FGF21 secretion, PGC-1alpha and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle.	Iron	86-90	fibroblast growth factor 21	Homo sapiens	9-14
23943793-4	2014	These Fe-S cluster-deficient muscles showed a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21).	Iron	6-10	fibroblast growth factor 21	Homo sapiens	125-130
23943793-4	2014	These Fe-S cluster-deficient muscles showed a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21).	Iron	6-10	fibroblast growth factor 21	Homo sapiens	132-159
24239078-9	2014	In addition, the increase in serum hepcidin in anemic rats observed in the current study also explains and supports the higher liver Fe content after supplying goat milk, because it blocks the liberation of Fe from hepatocytes, increasing its storage in liver.	Iron	133-135	hepcidin antimicrobial peptide	Rattus norvegicus	35-43
24748360-0	2014	Morbidity among iron ore mine workers in Goa.	Iron	16-20	tripartite motif containing 47	Homo sapiens	41-44
23860963-1	2014	PURPOSE: Disturbed iron homeostasis contributes to resistance to recombinant human erythropoietin (rHuEpo) in hemodialysis (HD) patients.	Iron	19-23	erythropoietin	Homo sapiens	83-97
24239078-9	2014	In addition, the increase in serum hepcidin in anemic rats observed in the current study also explains and supports the higher liver Fe content after supplying goat milk, because it blocks the liberation of Fe from hepatocytes, increasing its storage in liver.	Iron	207-209	hepcidin antimicrobial peptide	Rattus norvegicus	35-43
24200878-6	2014	Previous works on complex formation equilibria of a first group of these ligands with iron and aluminium highlighted extremely good pMe values and gave evidence of the ability to scavenge iron from inside cells.	Iron	86-90	cystatin B	Homo sapiens	132-135
24200878-6	2014	Previous works on complex formation equilibria of a first group of these ligands with iron and aluminium highlighted extremely good pMe values and gave evidence of the ability to scavenge iron from inside cells.	Iron	188-192	cystatin B	Homo sapiens	132-135
24678217-5	2014	RESULTS: Significantly lower levels (P &lt; 0.05) of CD4+ T-cells and decreased CD4:CD8 ratios were observed in the iron deficient children.	Iron	116-120	CD4 molecule	Homo sapiens	53-56
24678217-5	2014	RESULTS: Significantly lower levels (P &lt; 0.05) of CD4+ T-cells and decreased CD4:CD8 ratios were observed in the iron deficient children.	Iron	116-120	CD4 molecule	Homo sapiens	80-83
24678217-6	2014	Iron supplementation significantly improved the CD4+ cell counts and CD4:CD8 ratios.	Iron	0-4	CD4 molecule	Homo sapiens	48-51
24678217-6	2014	Iron supplementation significantly improved the CD4+ cell counts and CD4:CD8 ratios.	Iron	0-4	CD4 molecule	Homo sapiens	69-72
24564401-9	2014	A hypothetical increase in PAL from 1.4 to 1.9 was associated with a DRI that was 8%-13% higher for folate and vitamin C (men) and 5%-15% higher for calcium and iron (women).	Iron	161-165	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	27-30
24238846-4	2014	Elevated OS was also reported in pregnant women supplemented with iron, which can generate OS and may also influence insulin resistance.	Iron	66-70	insulin	Homo sapiens	117-124
24157836-7	2014	Finally, FBXL5 is highly sensitive to stress conditions and is downregulated by iron depletion and gamma-irradiation, explaining Snail1 stabilization in these conditions.	Iron	80-84	F-box and leucine rich repeat protein 5	Homo sapiens	9-14
24157836-7	2014	Finally, FBXL5 is highly sensitive to stress conditions and is downregulated by iron depletion and gamma-irradiation, explaining Snail1 stabilization in these conditions.	Iron	80-84	snail family transcriptional repressor 1	Homo sapiens	129-135
24174620-8	2014	Increased iron efflux from knockdown cells was likely mediated via transcriptional activation of the ferroportin 1 gene (by an unknown mechanism).	Iron	10-14	solute carrier family 40 member 1	Rattus norvegicus	101-114
29255838-8	2014	This mitochondrial degeneration produces intracellular deposits of iron and copper, metals that have been shown to harmfully interact with cleavage products of amyloid precursor protein.	Iron	67-71	amyloid beta precursor protein	Homo sapiens	160-185
24523110-4	2014	The great diversity of reactions catalyzed by CYP enzymes appears to be based on two unique properties of these heme proteins, the ability of their iron to exist under multiple oxidation states with different reactivities and a flexible active site that can accommodate a wide variety of substrates.	Iron	148-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-49
24456271-2	2014	Such a process is linked to the binding of metal ions (e.g., Cu, Fe and Zn) with Abeta.	Iron	65-67	amyloid beta precursor protein	Homo sapiens	81-86
24498631-2	2014	Mutations in Fe-S proteins often disrupt Fe-S cluster assembly leading to a spectrum of severe disorders such as Friedreich"s ataxia or iron-sulfur cluster assembly enzyme (ISCU) myopathy.	Iron	13-15	iron-sulfur cluster assembly enzyme	Homo sapiens	173-177
24498631-2	2014	Mutations in Fe-S proteins often disrupt Fe-S cluster assembly leading to a spectrum of severe disorders such as Friedreich"s ataxia or iron-sulfur cluster assembly enzyme (ISCU) myopathy.	Iron	13-17	iron-sulfur cluster assembly enzyme	Homo sapiens	173-177
24498631-2	2014	Mutations in Fe-S proteins often disrupt Fe-S cluster assembly leading to a spectrum of severe disorders such as Friedreich"s ataxia or iron-sulfur cluster assembly enzyme (ISCU) myopathy.	Iron	136-140	iron-sulfur cluster assembly enzyme	Homo sapiens	173-177
24988611-8	2014	The main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein).	Iron	34-38	transferrin	Homo sapiens	126-137
24672634-3	2014	We genotyped, in a cohort of ALS patients (n = 145) and healthy controls (n = 168), three SNPs in Nrf2 gene promoter: -653 A/G, -651 G/A, and -617 C/A and evaluated, in a subset (n = 73) of patients, advanced oxidation protein products (AOPP), iron-reducing ability of plasma (FRAP), and plasma thiols (-SH) as oxidative damage peripheral biomarkers.	Iron	244-248	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
24391488-8	2014	We find that the presence of two BMP-responsive elements enhances the steepness of the promoter response towards the iron-sensing BMP signaling axis, which promotes iron homeostasis in vivo.	Iron	117-121	bone morphogenetic protein 6	Homo sapiens	33-36
24391488-8	2014	We find that the presence of two BMP-responsive elements enhances the steepness of the promoter response towards the iron-sensing BMP signaling axis, which promotes iron homeostasis in vivo.	Iron	117-121	bone morphogenetic protein 6	Homo sapiens	130-133
24391488-8	2014	We find that the presence of two BMP-responsive elements enhances the steepness of the promoter response towards the iron-sensing BMP signaling axis, which promotes iron homeostasis in vivo.	Iron	165-169	bone morphogenetic protein 6	Homo sapiens	33-36
24391488-8	2014	We find that the presence of two BMP-responsive elements enhances the steepness of the promoter response towards the iron-sensing BMP signaling axis, which promotes iron homeostasis in vivo.	Iron	165-169	bone morphogenetic protein 6	Homo sapiens	130-133
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	25-27	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	86-92
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	25-27	gibberellin 3-oxidase 1	Arabidopsis thaliana	106-119
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	86-92
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	gibberellin 3-oxidase 1	Arabidopsis thaliana	106-119
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	86-92
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	gibberellin 3-oxidase 1	Arabidopsis thaliana	106-119
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	86-92
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	gibberellin 3-oxidase 1	Arabidopsis thaliana	106-119
24988611-8	2014	The main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein).	Iron	110-114	transferrin	Homo sapiens	126-137
24988611-8	2014	The main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein).	Iron	110-114	transferrin	Homo sapiens	126-137
24864466-8	2014	There was also a strong correlation between serum Klotho and ferritin levels and transferrin saturation percentage, which suggests that Klotho may be involved in iron regulation.	Iron	162-166	transferrin	Homo sapiens	81-92
25276251-6	2014	The results of studies suggest that iron absorption is regulated by the control of iron export from duodenal enterocytes to the circulating transferrin pool by ferroportin.	Iron	36-40	transferrin	Homo sapiens	140-151
25276251-6	2014	The results of studies suggest that iron absorption is regulated by the control of iron export from duodenal enterocytes to the circulating transferrin pool by ferroportin.	Iron	83-87	transferrin	Homo sapiens	140-151
24373521-4	2013	CKD patients are often treated with iv iron therapy in order to maintain iron stores and erythropoietin responsiveness, also in the case of not being iron depleted.	Iron	39-43	erythropoietin	Homo sapiens	89-103
24138026-5	2014	In addition, the disruption of intracellular trafficking caused by knocking out GAK destabilized the lysosomal membranes, resulting in DNA damage due to iron leakage.	Iron	153-157	cyclin G associated kinase	Mus musculus	80-83
25189388-3	2014	Unlike the native protein, cytochrome c within the complex binds ligands rapidly; in particular, NO can coordinate to either the ferric or ferrous iron of the heme.	Iron	147-151	cytochrome c, somatic	Homo sapiens	27-39
24427136-4	2013	For this purpose we introduced a conservative mode of iron chelation of dual activity, one based on scavenging labile metal but also redeploying it to cell acceptors or to physiological transferrin.	Iron	54-58	transferrin	Homo sapiens	186-197
24217246-1	2013	For iron-sulfur (Fe-S) cluster synthesis in mitochondria, the sulfur is derived from the amino acid cysteine by the cysteine desulfurase activity of Nfs1.	Iron	4-8	cysteine desulfurase	Saccharomyces cerevisiae S288C	149-153
24217246-1	2013	For iron-sulfur (Fe-S) cluster synthesis in mitochondria, the sulfur is derived from the amino acid cysteine by the cysteine desulfurase activity of Nfs1.	Iron	17-21	cysteine desulfurase	Saccharomyces cerevisiae S288C	149-153
24376607-8	2013	In CSF, prostaglandin E2 level was positively correlated with the levels of transferrin and lactoferrin, and tumor necrosis factor-alpha level was negatively correlated with the levels of iron, transferrin and lactoferrin in CSF.	Iron	188-192	tumor necrosis factor	Homo sapiens	109-136
24245580-1	2013	We report a facile strategy to prepare iron nanosheets directly grown on graphene sheets nanocomposite (C-PGF) through the carbonization of iron ions adsorbed onto polyaniline nanosheet/graphene oxide hybrid material.	Iron	39-43	placental growth factor	Homo sapiens	106-109
24245580-1	2013	We report a facile strategy to prepare iron nanosheets directly grown on graphene sheets nanocomposite (C-PGF) through the carbonization of iron ions adsorbed onto polyaniline nanosheet/graphene oxide hybrid material.	Iron	140-144	placental growth factor	Homo sapiens	106-109
24245580-2	2013	Because of the synergistic effect of iron nanosheets and graphene sheets, the as-obtained C-PGF exhibits an ultrahigh capacitance of ca.	Iron	37-41	placental growth factor	Homo sapiens	92-95
25206665-3	2013	We conjectured that iron overload-induced neurotoxicity might be associated with oxidative stress and the NF-E2-related factor 2 (Nrf2)/ARE signaling pathway.	Iron	20-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-128
25206665-3	2013	We conjectured that iron overload-induced neurotoxicity might be associated with oxidative stress and the NF-E2-related factor 2 (Nrf2)/ARE signaling pathway.	Iron	20-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
25206665-10	2013	These results indicate that iron overload aggravates oxidative stress injury in neural cells under high glucose concentration and that the Nrf2/ARE signaling pathway might play an important role in this process.	Iron	28-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	139-143
24231263-0	2013	Separation of iron-free and iron-saturated forms of transferrin and lactoferrin via capillary electrophoresis performed in fused-silica and neutral capillaries.	Iron	28-32	transferrin	Homo sapiens	52-63
25489488-5	2014	Concerning gene expression of iron regulatory proteins, old rats presented significantly higher mRNA levels of hepcidin (Hamp), transferrin (TF), transferrin receptor 2 (TfR2) and hemojuvelin (HJV); divalent metal transporter 1 (DMT1) mRNA levels were significantly higher in duodenal tissue; EPO gene expression was significantly higher in liver and lower in kidney, and the expression of the EPOR was significantly higher in both liver and kidney.	Iron	30-34	hepcidin antimicrobial peptide	Rattus norvegicus	111-119
24231263-1	2013	A capillary electrophoresis-based method for the cost-effective and high efficient separation of iron-free and iron-saturated forms of two members of transferrin family: transferrin and lactoferrin has been developed.	Iron	97-101	transferrin	Homo sapiens	150-161
24231263-1	2013	A capillary electrophoresis-based method for the cost-effective and high efficient separation of iron-free and iron-saturated forms of two members of transferrin family: transferrin and lactoferrin has been developed.	Iron	97-101	transferrin	Homo sapiens	170-181
24231263-1	2013	A capillary electrophoresis-based method for the cost-effective and high efficient separation of iron-free and iron-saturated forms of two members of transferrin family: transferrin and lactoferrin has been developed.	Iron	111-115	transferrin	Homo sapiens	150-161
24231263-1	2013	A capillary electrophoresis-based method for the cost-effective and high efficient separation of iron-free and iron-saturated forms of two members of transferrin family: transferrin and lactoferrin has been developed.	Iron	111-115	transferrin	Homo sapiens	170-181
24304351-5	2013	The Fe-CN-Co electron transfer pathway is highlighted by a strongly XMCD dependent transition to a cyanide back bonding orbital, giving evidence for strong hybridization with Fe(III) t2g orbitals.	Iron	4-6	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	178-181
23907672-6	2013	Tf-USPIO enhanced the cellular iron content in TfR-NSCs 80 +- 18 % compared to USPIOs.	Iron	31-35	transferrin	Homo sapiens	0-2
24335710-0	2013	Zinc, iron and vitamins A, C and e are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children.	Iron	6-10	insulin	Homo sapiens	96-103
24335710-6	2013	Iron and vitamin E:lipids were negatively associated with insulin (p &lt; 0.05).	Iron	0-4	insulin	Homo sapiens	58-65
24335710-7	2013	Vitamins A, C and E and iron were negatively associated with CRP (p &lt; 0.05).	Iron	24-28	C-reactive protein	Homo sapiens	61-64
24120471-8	2013	CAT activity was significantly increased after 8h of Fe administration in cortex, hippocampus and striatum (1.4 fold, 86, and 47%, respectively).	Iron	53-55	catalase	Rattus norvegicus	0-3
24120471-9	2013	Fe response in the whole brain seems to lead to enhanced NF-kappaB DNA binding activity, which may contribute to limit oxygen reactive species-dependent damage by effects on the antioxidant enzyme CAT activity.	Iron	0-2	catalase	Rattus norvegicus	197-200
24312441-12	2013	IV iron was associated with a higher rate of achieving Hb response in comparison to oral iron; RR 1.25 (95% CI 1.04-1.51, I(2) = 2%, 4 trials), CRP levels and disease activity indexes were not significantly affected by IV iron.	Iron	3-7	C-reactive protein	Homo sapiens	144-147
24145678-18	2013	Significant predictors of Hb response to IV iron treatment were baseline Hb and C-reactive protein (CRP).	Iron	44-48	C-reactive protein	Homo sapiens	80-98
24145678-18	2013	Significant predictors of Hb response to IV iron treatment were baseline Hb and C-reactive protein (CRP).	Iron	44-48	C-reactive protein	Homo sapiens	100-103
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	93-97	poly(ADP-ribose) polymerase 1	Homo sapiens	6-11
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	93-97	poly(ADP-ribose) polymerase 1	Homo sapiens	152-157
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	129-133	poly(ADP-ribose) polymerase 1	Homo sapiens	6-11
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	129-133	poly(ADP-ribose) polymerase 1	Homo sapiens	152-157
24099549-3	2013	In this complex cytochrome c has its native axial Met(80) ligand dissociated from the haem-iron, considerably augmenting the peroxidase capability of the haem group upon H2O2 binding.	Iron	91-95	cytochrome c, somatic	Homo sapiens	16-28
24231326-0	2013	A new insight on the core-shell structure of zerovalent iron nanoparticles and its application for Pb(II) sequestration.	Iron	56-60	submaxillary gland androgen regulated protein 3B	Homo sapiens	99-105
24231326-6	2013	Combining the ratio of Fe-released to Pb-immobilized and the result of HR-XPS, a reaction between Fe(0) core, Fe(OH)3, and Pb(II) is proposed.	Iron	23-25	submaxillary gland androgen regulated protein 3B	Homo sapiens	123-129
24231326-6	2013	Combining the ratio of Fe-released to Pb-immobilized and the result of HR-XPS, a reaction between Fe(0) core, Fe(OH)3, and Pb(II) is proposed.	Iron	98-103	submaxillary gland androgen regulated protein 3B	Homo sapiens	123-129
24231326-7	2013	The Fe released from the Fe(0) core leads to the core depletion, observed by transmission electron microscopy (TEM) under high Pb(II) loading.	Iron	4-6	submaxillary gland androgen regulated protein 3B	Homo sapiens	127-133
24231326-7	2013	The Fe released from the Fe(0) core leads to the core depletion, observed by transmission electron microscopy (TEM) under high Pb(II) loading.	Iron	25-30	submaxillary gland androgen regulated protein 3B	Homo sapiens	127-133
24339866-8	2013	As upregulation of hepcidin by inflammation and iron status was blunted by erythropoietin in this population, enhanced iron absorption through the low hepcidin values may increase infection risk.	Iron	119-123	erythropoietin	Homo sapiens	75-89
24367239-1	2013	Erythropoietin stimulating agents had a long haul in Lithuania--we had no epoetin till 1994 and there was no intravenous iron in 2001-2004.	Iron	121-125	erythropoietin	Homo sapiens	0-14
24349622-1	2013	BACK GROUND: Overt and subtle iron overload cause diabetes by lowering insulin production and promoting insulin resistance.	Iron	30-34	insulin	Homo sapiens	71-78
24349622-1	2013	BACK GROUND: Overt and subtle iron overload cause diabetes by lowering insulin production and promoting insulin resistance.	Iron	30-34	insulin	Homo sapiens	104-111
24349622-2	2013	Via divalent metal transporters pancreatic beta cells take up non-transferrin-bound iron which by catalyzing Fenton reaction can cause oxidative stress.	Iron	84-88	transferrin	Homo sapiens	66-77
24349622-10	2013	These findings suggest that indiscriminate use of IV iron may impair insulin production capacity in ESRD patients the majority of whom have Type-2 diabetes.	Iron	53-57	insulin	Homo sapiens	69-76
23983135-9	2013	Heme iron intake was positively associated with the risk of P53 overexpressed tumors but not with tumors without P53 overexpression (Pheterogeneity = 0.12).	Iron	5-9	tumor protein p53	Homo sapiens	60-63
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Iron	224-228	apolipoprotein A-I	Salmo salar	153-158
23983135-10	2013	Heme iron intake was associated with an increased risk of colorectal tumors harboring G&gt;A transitions in KRAS and APC and overexpression of P53.	Iron	5-9	tumor protein p53	Homo sapiens	143-146
23312547-3	2013	We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that is saturated with iron) with pre-diabetes (preDM) in US adults without chronic kidney disease, anemia, and iron deficiency.	Iron	221-225	transferrin	Homo sapiens	126-137
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Iron	224-228	beta-2-microglobulin	Salmo salar	167-170
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Iron	224-228	glyceraldehyde-3-phosphate dehydrogenase	Salmo salar	189-194
24036104-8	2013	Oral administration of ferrous salts may lead to high transferrin saturation levels and, thus, formation of non-transferrin-bound iron, a potentially toxic form of iron with a propensity to induce oxidative stress.	Iron	130-134	transferrin	Homo sapiens	112-123
23796160-1	2013	AIM: Increased body iron is associated with insulin resistance.	Iron	20-24	insulin	Homo sapiens	44-51
23796160-3	2013	We hypothesized that individuals with insulin resistance have inadequate hepcidin levels for their iron load.	Iron	99-103	insulin	Homo sapiens	38-45
23796160-12	2013	Reduced hepcidin concentrations may cause increased body iron stores in insulin-resistant states.	Iron	57-61	insulin	Homo sapiens	72-79
23792772-9	2013	The results clearly showed that increased expression of Mn-SOD significantly lowered the levels of labile iron in heart, liver, kidney, and skeletal muscle, whereas decreased expression of Mn-SOD significantly increased the levels of labile iron in the same organs.	Iron	106-110	superoxide dismutase 2, mitochondrial	Mus musculus	56-62
23792772-9	2013	The results clearly showed that increased expression of Mn-SOD significantly lowered the levels of labile iron in heart, liver, kidney, and skeletal muscle, whereas decreased expression of Mn-SOD significantly increased the levels of labile iron in the same organs.	Iron	241-245	superoxide dismutase 2, mitochondrial	Mus musculus	189-195
24036104-8	2013	Oral administration of ferrous salts may lead to high transferrin saturation levels and, thus, formation of non-transferrin-bound iron, a potentially toxic form of iron with a propensity to induce oxidative stress.	Iron	164-168	transferrin	Homo sapiens	112-123
23962819-1	2013	Regulation of iron metabolism in Saccharomyces cerevisiae is achieved at the transcriptional level by low (Aft1 and Aft2) and high iron-sensing (Yap5) transcription factors, and at the post-transcriptional level by mRNA-binding proteins (Cth1 and Cth2).	Iron	14-18	Aft2p	Saccharomyces cerevisiae S288C	116-120
23770082-5	2013	When lysosomal membranes were stabilized by the iron-chelating agent desferrioxamine, H2O2-induced increase in DNA damage, Noxa expression, and subsequent apoptosis were abolished by the inhibition of LMP.	Iron	48-52	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	123-127
23770082-7	2013	Finally, exogenous iron loading recapitulated the effects of H2O2 on the expression of BH3-only Bcl-2 proteins.	Iron	19-23	BCL2 apoptosis regulator	Homo sapiens	96-101
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	thioredoxin peroxidase TSA2	Saccharomyces cerevisiae S288C	201-205
24074273-8	2013	Deletion of either of the iron homeostasis regulators AFT1 or AFT2 also resulted in sensitivity to LoaOOH.	Iron	26-30	Aft2p	Saccharomyces cerevisiae S288C	62-66
24771904-7	2013	HO-1 metabolizes heme to biliverdin, iron and carbon monoxide (CO).	Iron	37-41	heme oxygenase 1	Mus musculus	0-4
23749468-0	2013	CHOP-mediated hepcidin suppression modulates hepatic iron load.	Iron	53-57	DNA damage inducible transcript 3	Homo sapiens	0-4
23787477-9	2013	Serum iron and ferritin levels declined rapidly on MG2 and MG4 (P &lt; 0.001).	Iron	6-10	mucolipin TRP cation channel 1	Homo sapiens	51-54
23867320-6	2013	Functional deficit of iron should also be excluded in patients with normal ferritin and lower saturation of transferrin.	Iron	22-26	transferrin	Homo sapiens	108-119
24266357-2	2013	The presence of surface receptors for the host iron-binding glycoproteins transferrin (Tf) and lactoferrin (Lf) in globally important Gram-negative bacterial pathogens of humans and food production animals suggests that Tf and Lf are important sources of iron in the upper respiratory or genitourinary tracts, where they exclusively reside.	Iron	47-51	transferrin	Homo sapiens	74-85
24266357-2	2013	The presence of surface receptors for the host iron-binding glycoproteins transferrin (Tf) and lactoferrin (Lf) in globally important Gram-negative bacterial pathogens of humans and food production animals suggests that Tf and Lf are important sources of iron in the upper respiratory or genitourinary tracts, where they exclusively reside.	Iron	47-51	transferrin	Homo sapiens	87-89
24266357-2	2013	The presence of surface receptors for the host iron-binding glycoproteins transferrin (Tf) and lactoferrin (Lf) in globally important Gram-negative bacterial pathogens of humans and food production animals suggests that Tf and Lf are important sources of iron in the upper respiratory or genitourinary tracts, where they exclusively reside.	Iron	47-51	transferrin	Homo sapiens	220-222
24266357-2	2013	The presence of surface receptors for the host iron-binding glycoproteins transferrin (Tf) and lactoferrin (Lf) in globally important Gram-negative bacterial pathogens of humans and food production animals suggests that Tf and Lf are important sources of iron in the upper respiratory or genitourinary tracts, where they exclusively reside.	Iron	255-259	transferrin	Homo sapiens	74-85
24266357-2	2013	The presence of surface receptors for the host iron-binding glycoproteins transferrin (Tf) and lactoferrin (Lf) in globally important Gram-negative bacterial pathogens of humans and food production animals suggests that Tf and Lf are important sources of iron in the upper respiratory or genitourinary tracts, where they exclusively reside.	Iron	255-259	transferrin	Homo sapiens	87-89
24266357-2	2013	The presence of surface receptors for the host iron-binding glycoproteins transferrin (Tf) and lactoferrin (Lf) in globally important Gram-negative bacterial pathogens of humans and food production animals suggests that Tf and Lf are important sources of iron in the upper respiratory or genitourinary tracts, where they exclusively reside.	Iron	255-259	transferrin	Homo sapiens	220-222
23989406-1	2013	The eukaryotic anamorsin protein family, which has recently been proposed to be part of an electron transfer chain functioning in the early steps of cytosolic iron-sulfur (Fe/S) protein biogenesis, is characterized by a largely unstructured domain (CIAPIN1) containing two conserved cysteine-rich motifs (CX8CX2CXC and CX2CX7CX2C) whose Fe/S binding properties and electronic structures are not well defined.	Iron	159-163	cytokine induced apoptosis inhibitor 1	Homo sapiens	15-24
23989406-1	2013	The eukaryotic anamorsin protein family, which has recently been proposed to be part of an electron transfer chain functioning in the early steps of cytosolic iron-sulfur (Fe/S) protein biogenesis, is characterized by a largely unstructured domain (CIAPIN1) containing two conserved cysteine-rich motifs (CX8CX2CXC and CX2CX7CX2C) whose Fe/S binding properties and electronic structures are not well defined.	Iron	172-174	cytokine induced apoptosis inhibitor 1	Homo sapiens	15-24
23989406-1	2013	The eukaryotic anamorsin protein family, which has recently been proposed to be part of an electron transfer chain functioning in the early steps of cytosolic iron-sulfur (Fe/S) protein biogenesis, is characterized by a largely unstructured domain (CIAPIN1) containing two conserved cysteine-rich motifs (CX8CX2CXC and CX2CX7CX2C) whose Fe/S binding properties and electronic structures are not well defined.	Iron	337-339	cytokine induced apoptosis inhibitor 1	Homo sapiens	15-24
23989406-1	2013	The eukaryotic anamorsin protein family, which has recently been proposed to be part of an electron transfer chain functioning in the early steps of cytosolic iron-sulfur (Fe/S) protein biogenesis, is characterized by a largely unstructured domain (CIAPIN1) containing two conserved cysteine-rich motifs (CX8CX2CXC and CX2CX7CX2C) whose Fe/S binding properties and electronic structures are not well defined.	Iron	337-339	cytokine induced apoptosis inhibitor 1	Homo sapiens	249-256
24100622-6	2013	The genes most highly induced by cFP comprised those associated with the transport and metabolism of inorganic molecules, particularly iron.	Iron	135-139	complement factor properdin	Homo sapiens	33-36
24211145-5	2013	For elevated levels of estrogen alter the synthesis and/or activity of several factors involved in iron metabolism including hypoxia inducible factor 1alpha (HIF-1alpha) and hepcidin among others.	Iron	99-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-156
24121729-0	2013	Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice.	Iron	13-17	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	74-81
24121729-8	2013	Interestingly, when considering possible epistatic interactions, the effects of Mon1a on macrophage iron export are conditioned by the genotype at the Slc40a1 locus.	Iron	100-104	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	151-158
24121729-11	2013	This study highlights the existence of genetic interactions between Cp, Mon1a, and the Slc40a1 locus in iron metabolism, suggesting that epistasis may be a crucial determinant of the variable biological and clinical presentations in iron disorders.	Iron	104-108	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	87-94
24126888-5	2013	Iron overload also led to induction of unfolded protein response (XBP1 splicing, activation of IRE-1alpha and PERK, as well as sequestration of GRP78) and ER stress (increased CHOP protein expression) following HFD and ethanol.	Iron	0-4	X-box binding protein 1	Mus musculus	66-70
24126888-5	2013	Iron overload also led to induction of unfolded protein response (XBP1 splicing, activation of IRE-1alpha and PERK, as well as sequestration of GRP78) and ER stress (increased CHOP protein expression) following HFD and ethanol.	Iron	0-4	heat shock protein 5	Mus musculus	144-149
24211145-5	2013	For elevated levels of estrogen alter the synthesis and/or activity of several factors involved in iron metabolism including hypoxia inducible factor 1alpha (HIF-1alpha) and hepcidin among others.	Iron	99-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-168
24282517-7	2013	Patients with A-A-T seemed on average to have greater iron stores (p = 0.021), but significant differences were not confirmed in the 3 separate populations.	Iron	54-58	serpin family A member 1	Homo sapiens	14-19
24184477-3	2013	Iron in super paramagnetic iron-oxide nanoparticle (SPION) induces a phenotypic shift in THP1 derived M2 macrophages towards a high CD86+ and high TNF alpha+ macrophage subtype.	Iron	0-4	GLI family zinc finger 2	Homo sapiens	89-93
24184477-3	2013	Iron in super paramagnetic iron-oxide nanoparticle (SPION) induces a phenotypic shift in THP1 derived M2 macrophages towards a high CD86+ and high TNF alpha+ macrophage subtype.	Iron	0-4	tumor necrosis factor	Homo sapiens	147-156
24164352-6	2013	It is observed that in wild-type cAOS the active site Thr66 residue consistently forms a strong hydrogen-bonding interaction with H2O2 (catalase substrate) and, importantly, with the aid of His67 helps to pull H2O2 away from the heme Fe center.	Iron	234-236	catalase	Homo sapiens	136-144
24282517-9	2013	Although A-A-T may signal a more severe iron phenotype, this study was unable to prove such an association in all population settings, precluding its use as a universal predictive marker of iron overload in HH.	Iron	40-44	serpin family A member 1	Homo sapiens	9-14
24152109-1	2013	It has been previously suggested that large amounts of oxalate in plasma could play a role in autism by binding to the bilobal iron transport protein transferrin (hTF), thereby interfering with iron metabolism by inhibiting the delivery of iron to cells.	Iron	127-131	transferrin	Homo sapiens	150-161
24278199-0	2013	Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species.	Iron	22-26	transferrin	Homo sapiens	4-15
24278199-2	2013	Plasma iron normally circulates bound to transferrin.	Iron	7-11	transferrin	Homo sapiens	41-52
24278268-2	2013	Since cell proliferation has a strong requirement for iron, cancer cells express high levels of transferrin receptors (TfnR), making its ligand, transferrin (Tfn), of great interest as a delivery agent for therapeutics.	Iron	54-58	transferrin	Homo sapiens	145-156
24312900-2	2013	In particular, iron is tightly bound to host proteins such as transferrin to maintain homeostasis, to limit potential damage caused by iron toxicity under physiological conditions and to restrict access by pathogens.	Iron	15-19	transferrin	Homo sapiens	62-73
24152109-1	2013	It has been previously suggested that large amounts of oxalate in plasma could play a role in autism by binding to the bilobal iron transport protein transferrin (hTF), thereby interfering with iron metabolism by inhibiting the delivery of iron to cells.	Iron	194-198	transferrin	Homo sapiens	150-161
24312900-2	2013	In particular, iron is tightly bound to host proteins such as transferrin to maintain homeostasis, to limit potential damage caused by iron toxicity under physiological conditions and to restrict access by pathogens.	Iron	135-139	transferrin	Homo sapiens	62-73
24233717-1	2013	Cytochrome P450 enzymes activate oxygen at heme iron centers to oxidize relatively inert substrate carbon-hydrogen bonds.	Iron	48-52	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
24312900-6	2013	Indeed, siderophore production and transport, iron acquisition from heme and host iron-containing proteins such as hemoglobin and transferrin, and reduction of ferric to ferrous iron with subsequent transport are all strategies found in bacterial and fungal pathogens of humans.	Iron	46-50	transferrin	Homo sapiens	130-141
24312900-6	2013	Indeed, siderophore production and transport, iron acquisition from heme and host iron-containing proteins such as hemoglobin and transferrin, and reduction of ferric to ferrous iron with subsequent transport are all strategies found in bacterial and fungal pathogens of humans.	Iron	82-86	transferrin	Homo sapiens	130-141
24312900-6	2013	Indeed, siderophore production and transport, iron acquisition from heme and host iron-containing proteins such as hemoglobin and transferrin, and reduction of ferric to ferrous iron with subsequent transport are all strategies found in bacterial and fungal pathogens of humans.	Iron	82-86	transferrin	Homo sapiens	130-141
23814038-0	2013	Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.	Iron	29-33	LYR motif containing 4	Homo sapiens	13-18
23814038-0	2013	Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.	Iron	29-33	LYR motif containing 4	Homo sapiens	67-72
24223168-0	2013	Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice.	Iron	8-12	interleukin 6	Mus musculus	47-51
24036496-4	2013	In vitro IL-4 polarization of human monocytes into M2 macrophages also resulted in a gene expression profile and phenotype favoring iron accumulation.	Iron	132-136	interleukin 4	Homo sapiens	9-13
24255894-4	2013	Haptoglobin (Hp) is an antioxidant plasma protein which binds free hemoglobin, thus preventing heme-iron mediated oxidation.	Iron	100-104	haptoglobin	Homo sapiens	0-11
24204370-9	2013	Six members of the plant specific, ROXY glutaredoxins and three BHLH transcription factors involved in iron homeostasis were strongly upregulated, supporting a role for GSNOR in redox and iron metabolism.	Iron	103-107	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	169-174
24204370-9	2013	Six members of the plant specific, ROXY glutaredoxins and three BHLH transcription factors involved in iron homeostasis were strongly upregulated, supporting a role for GSNOR in redox and iron metabolism.	Iron	188-192	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	169-174
24054466-3	2013	Specifically, we agreed that a therapeutic trial of iron is appropriate in cases in which a reduction in erythropoiesis-stimulating agent (ESA) dosage or avoidance of ESA and transfusion is desired, transferrin saturations are &gt;30%, and ferritin concentrations are &gt;500 mug/L.	Iron	52-56	transferrin	Homo sapiens	199-210
24035742-7	2013	Treatment of MPO with high H2O2 concentrations resulted in complete inactivation, Compound III formation, destruction of the heme groups, release of their iron, and detachment of the small polypeptide chain of MPO.	Iron	155-159	myeloperoxidase	Homo sapiens	13-16
24223168-0	2013	Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice.	Iron	8-12	signal transducer and activator of transcription 3	Mus musculus	58-63
24223168-2	2013	The role of Stat3 activation in iron-induced colonic inflammation and tumorigenesis was investigated in a mouse model of inflammation-associated colorectal cancer.	Iron	32-36	signal transducer and activator of transcription 3	Mus musculus	12-17
24223168-5	2013	Colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS treatment, with enhanced colonic IL-6 and IL-11 release and Stat3 phosphorylation.	Iron	52-56	interleukin 6	Mus musculus	150-154
24223168-5	2013	Colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS treatment, with enhanced colonic IL-6 and IL-11 release and Stat3 phosphorylation.	Iron	52-56	signal transducer and activator of transcription 3	Mus musculus	177-182
24223168-6	2013	Both IL-6 and ferritin, the iron storage protein, co-localized with macrophages suggesting iron may act directly on IL-6 producing-macrophages.	Iron	91-95	interleukin 6	Mus musculus	5-9
24223168-6	2013	Both IL-6 and ferritin, the iron storage protein, co-localized with macrophages suggesting iron may act directly on IL-6 producing-macrophages.	Iron	91-95	interleukin 6	Mus musculus	116-120
24223168-10	2013	Intratumoral IL-6 and IL-11 expression increased in DSS-treated mice and IL-6, and possibly IL-11, were enhanced by dietary iron.	Iron	124-128	interleukin 6	Mus musculus	73-77
24223168-12	2013	Dietary iron and colonic inflammation synergistically activated colonic IL-6/IL-11-Stat3 signaling promoting tumorigenesis.	Iron	8-12	interleukin 6	Mus musculus	72-76
24223168-12	2013	Dietary iron and colonic inflammation synergistically activated colonic IL-6/IL-11-Stat3 signaling promoting tumorigenesis.	Iron	8-12	signal transducer and activator of transcription 3	Mus musculus	83-88
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	Iron	132-136	catalase	Homo sapiens	16-24
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	Iron	158-162	superoxide dismutase 1	Homo sapiens	51-54
24075960-1	2013	Pantothenate kinase-associated neurodegeneration (PKAN) disease is an autosomal recessive neurodegenerative disorder with iron storage in the brain due to PANK2 gene mutations.	Iron	122-126	pantothenate kinase 2	Homo sapiens	155-160
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	Iron	132-136	superoxide dismutase 1	Homo sapiens	29-49
23768398-6	2013	SOD, which catalyses the dismutation of superoxide into hydrogen peroxide, should have stimulated the formation of radicals, since these radicals are generated from the reaction between hydrogen peroxide and iron(II).	Iron	208-212	superoxide dismutase 1	Homo sapiens	0-3
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	Iron	132-136	superoxide dismutase 1	Homo sapiens	51-54
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	Iron	158-162	catalase	Homo sapiens	16-24
23768398-5	2013	The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation.	Iron	158-162	superoxide dismutase 1	Homo sapiens	29-49
23504908-0	2013	Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis.	Iron	73-77	proprotein convertase subtilisin/kexin type 7	Homo sapiens	37-42
24402666-1	2013	It is well-known the central role of inflammation in the inhibition of erythropoiesis and iron availability in chronic kidney disease (CKD) patients with erythropoietin (EPO)-resistant anaemia.	Iron	90-94	erythropoietin	Homo sapiens	154-168
24402666-1	2013	It is well-known the central role of inflammation in the inhibition of erythropoiesis and iron availability in chronic kidney disease (CKD) patients with erythropoietin (EPO)-resistant anaemia.	Iron	90-94	erythropoietin	Homo sapiens	170-173
24402666-2	2013	This inflammatory action is mediated by suppressive cytokines (i.e. IL-6, TNF-, INF-) inhibiting differentiation and proliferation activities of erythroid cells in the EPO-indipendent phase of erythropoiesis and stimulating hepcidin production for iron retention in reticulo-endothelial system and enterocytes.	Iron	248-252	interleukin 6	Homo sapiens	68-85
24402666-2	2013	This inflammatory action is mediated by suppressive cytokines (i.e. IL-6, TNF-, INF-) inhibiting differentiation and proliferation activities of erythroid cells in the EPO-indipendent phase of erythropoiesis and stimulating hepcidin production for iron retention in reticulo-endothelial system and enterocytes.	Iron	248-252	erythropoietin	Homo sapiens	168-171
23980114-11	2013	Compatible with a role in the ecology and pathogenesis of L. pneumophila, HGA and HGA-melanin were effective at reducing and releasing iron from both insoluble ferric hydroxide and the mammalian iron chelates ferritin and transferrin.	Iron	135-139	transferrin	Homo sapiens	222-233
23891537-2	2013	Patients with PKAN present with a progressive neurological decline and brain iron accumulation, but general energy balance and nutrition status among these patients has not been reported.	Iron	77-81	pantothenate kinase 2	Homo sapiens	14-18
24047900-7	2013	The structures suggest that although a precise fit between the shape of the inhibitor molecules and T. cruzi CYP51 active site topology underlies their high inhibitory potency, a longer coordination bond between the catalytic heme iron and the pyridine nitrogen implies a weaker influence of pyridines on the iron reduction potential, which may be the basis for the observed selectivity of these compounds toward the target enzyme versus other cytochrome P450s, including human drug-metabolizing P450s.	Iron	231-235	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	109-114
24047900-7	2013	The structures suggest that although a precise fit between the shape of the inhibitor molecules and T. cruzi CYP51 active site topology underlies their high inhibitory potency, a longer coordination bond between the catalytic heme iron and the pyridine nitrogen implies a weaker influence of pyridines on the iron reduction potential, which may be the basis for the observed selectivity of these compounds toward the target enzyme versus other cytochrome P450s, including human drug-metabolizing P450s.	Iron	309-313	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	109-114
24167545-0	2013	Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance.	Iron	91-95	bone gamma-carboxyglutamate protein	Homo sapiens	39-50
23796662-12	2013	Worsening of iron accumulation is thus a potential side effect of Abeta-immunization at prodromal stages of Alzheimer"s disease, and should be monitored in clinical trials.	Iron	13-17	amyloid beta precursor protein	Homo sapiens	66-71
24169614-2	2013	Such iron indices as ferritin and transferrin saturation (TSAT) values are used to guide management of anemia in individuals on maintenance hemodialysis (MHD).	Iron	5-9	transferrin	Homo sapiens	34-45
24167545-0	2013	Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance.	Iron	91-95	insulin	Homo sapiens	104-111
24167545-2	2013	Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.	Iron	60-64	bone gamma-carboxyglutamate protein	Homo sapiens	35-46
24167545-2	2013	Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.	Iron	181-185	bone gamma-carboxyglutamate protein	Homo sapiens	35-46
24167545-2	2013	Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.	Iron	181-185	bone gamma-carboxyglutamate protein	Homo sapiens	119-130
24167545-2	2013	Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.	Iron	181-185	bone gamma-carboxyglutamate protein	Homo sapiens	119-130
24167545-2	2013	Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.	Iron	181-185	bone gamma-carboxyglutamate protein	Homo sapiens	35-46
24167545-2	2013	Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.	Iron	181-185	bone gamma-carboxyglutamate protein	Homo sapiens	119-130
24167545-2	2013	Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.	Iron	181-185	bone gamma-carboxyglutamate protein	Homo sapiens	119-130
24167545-9	2013	CONCLUSIONS: We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.	Iron	203-207	bone gamma-carboxyglutamate protein	Homo sapiens	107-118
24045011-2	2013	One of the early actors in Fe-S cluster biosynthesis is a protein complex composed of a cysteine desulphurase, Nfs1, and its functional binding partner, Isd11.	Iron	27-31	LYR motif containing 4	Homo sapiens	153-158
24167545-9	2013	CONCLUSIONS: We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.	Iron	203-207	adiponectin, C1Q and collagen domain containing	Homo sapiens	150-161
24167545-9	2013	CONCLUSIONS: We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.	Iron	203-207	insulin	Homo sapiens	243-250
24139179-17	2013	Redox-active iron was also elevated in the AD choroid plexus and in vitro addition of Fe+3Cl3 to cultured epithelial cells induced hBD-1 mRNA expression.	Iron	13-17	defensin beta 1	Homo sapiens	131-136
23990467-2	2013	Iron uptake by osteoclast precursors via the transferrin cycle increases mitochondrial biogenesis, reactive oxygen species production, and activation of cAMP response element-binding protein, a critical transcription factor downstream of receptor activator of NF-kappaB-ligand-induced calcium signaling.	Iron	0-4	transferrin	Homo sapiens	45-56
24139179-20	2013	We also demonstrate that increased iron deposition in AD may contribute to the elevated expression of hBD-1 within the choroid plexus.	Iron	35-39	defensin beta 1	Homo sapiens	102-107
23904222-3	2013	Heme oxygenase (HO)-1 cleaves heme to form biliverdin, carbon monoxide (CO), and iron (Fe(2+)), which is used with 5-ALA.	Iron	81-85	heme oxygenase 1	Mus musculus	0-21
23904222-3	2013	Heme oxygenase (HO)-1 cleaves heme to form biliverdin, carbon monoxide (CO), and iron (Fe(2+)), which is used with 5-ALA.	Iron	87-89	heme oxygenase 1	Mus musculus	0-21
24130551-7	2013	Group A dolphins with high insulin (greater than 14 muIU/ml) had higher glucose, iron, GGT, and BMI compared to Group A dolphins with lower insulin.	Iron	81-85	insulin	Homo sapiens	27-34
23892322-11	2013	Aluminum, iron and chromium ions cause DNA damage at 50 muM.	Iron	10-14	latexin	Homo sapiens	56-59
24130795-9	2013	Molecular testing for PLA2G6 mutations is, therefore, indicated in childhood-onset ataxia syndromes, if neuroimaging shows cerebellar atrophy with or without evidence of iron accumulation.	Iron	170-174	phospholipase A2 group VI	Homo sapiens	22-28
23940031-0	2013	Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).	Iron	197-201	heat shock protein family A (Hsp70) member 9	Homo sapiens	31-38
24348638-9	2013	CONCLUSIONS: This study revealed that serum iron markers (especially ferritin and transferrin) might be used as surrogate markers for both liver fibrosis and necroinflammatory activity.Patients with chronic hepatitis C (CHC) often have elevated serum iron markers, which may worsen liver injury.	Iron	44-48	transferrin	Homo sapiens	82-93
24146543-16	2013	This is the first study to demonstrate that hydrogen peroxide and an inhibitor of ERK1/2 activation can increase the levels of the iron storage protein, ferritin.	Iron	131-135	mitogen-activated protein kinase 1	Canis lupus familiaris	82-88
24146543-17	2013	Since ferritin can shield cells from iron-catalyzed damage, this downstream effect likely plays a protective role, which, in the case of the ERK1/2 inhibitor, U-0126, demonstrates a potential therapeutic target.	Iron	37-41	mitogen-activated protein kinase 1	Canis lupus familiaris	141-147
23742171-9	2013	Iron and EtOH feeding markedly reduced p-STAT3 and p-AMPK protein levels, but this effect was significantly attenuated when a CO diet was consumed.	Iron	0-4	signal transducer and activator of transcription 3	Mus musculus	41-46
24455185-3	2013	Neolactoferrin saturated with iron ions increased the synthesis of pro-inflammatory cytokine TNFalpha.	Iron	30-34	tumor necrosis factor	Homo sapiens	93-101
24098554-2	2013	PKAN is also assigned to a group of rare neurodegenerative diseases, known as NBIA (neurodegeneration with brain iron accumulation), associated with iron accumulation in the basal ganglia and progressive movement disorder.	Iron	113-117	pantothenate kinase 2	Homo sapiens	0-4
24098554-2	2013	PKAN is also assigned to a group of rare neurodegenerative diseases, known as NBIA (neurodegeneration with brain iron accumulation), associated with iron accumulation in the basal ganglia and progressive movement disorder.	Iron	149-153	pantothenate kinase 2	Homo sapiens	0-4
23800229-2	2013	The mitochondrial carrier family members Mrs3 and Mrs4 (homologues of vertebrate mitoferrin) function in organellar iron supply, yet other low efficiency transporters may exist.	Iron	116-120	Fe(2+) transporter	Saccharomyces cerevisiae S288C	41-45
23800229-8	2013	However, RIM2 deletion in mrs3/4Delta cells aggravates their Fe-S protein maturation defect.	Iron	61-65	Fe(2+) transporter	Saccharomyces cerevisiae S288C	26-30
23624305-0	2013	Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway.	Iron	41-45	myeloperoxidase	Homo sapiens	0-15
24075749-3	2013	We studied whether common variants of haptoglobin (Hp), which facilitates the removal of free hemoglobin and protects tissues from heme-iron induced oxidative damage, would modify the inflammatory response to IPH and the risk of unstable carotid stenosis (CS) and major cardiovascular diseases.	Iron	136-140	haptoglobin	Homo sapiens	38-49
23864430-0	2013	Functional binding analysis of human fibrinogen as an iron- and heme-binding protein.	Iron	54-58	fibrinogen beta chain	Homo sapiens	37-47
23864430-1	2013	Human fibrinogen is a metal ion-binding protein, but its mechanism of binding with iron and heme has not been elucidated in detail.	Iron	83-87	fibrinogen beta chain	Homo sapiens	6-16
23864430-3	2013	The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone.	Iron	34-38	fibrinogen beta chain	Homo sapiens	4-14
23864430-7	2013	These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions.	Iron	64-68	fibrinogen beta chain	Homo sapiens	33-43
23864430-7	2013	These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions.	Iron	179-183	fibrinogen beta chain	Homo sapiens	33-43
24120591-0	2013	Hypoxia-inducible factor-1alpha(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors.	Iron	67-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
24120591-2	2013	The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis.	Iron	153-157	erythropoietin	Homo sapiens	4-18
24120591-8	2013	DISCUSSION: These findings show for the first time that the HIF-1alpha(Pro-582-Ser) polymorphism significantly affects red blood cell and iron homeostasis after blood loss, conferring to male carriers a resistance to anaemia.	Iron	138-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
23896312-2	2013	While dopamine and iron availability in the brain modulate emergence of symptoms, and dopamine agonists and iron alleviate the sensory symptoms and motor signs of RLS, the biology of the disorder is incompletely understood.	Iron	108-112	RLS1	Homo sapiens	163-166
23595586-6	2013	In one study examining pregnant women with normal mean iron values, higher soluble transferrin receptor values independently predicted vaginosis-like microflora.	Iron	55-59	transferrin	Homo sapiens	83-94
23624305-7	2013	Stopped-flow measurements revealed that the HOCl-mediated MPO heme destruction was complex and occurred through transient ferric species whose formation and decay kinetics indicated it participates in heme destruction along with subsequent free iron release.	Iron	245-249	myeloperoxidase	Homo sapiens	58-61
23624305-8	2013	MPO heme depletion was confirmed by the buildup of free iron utilizing the ferrozine assay.	Iron	56-60	myeloperoxidase	Homo sapiens	0-3
23624305-11	2013	Collectively, this study elucidates the bidirectional relationship between MPO and HOCl, which highlights the potential role of MPO as a source of free iron.	Iron	152-156	myeloperoxidase	Homo sapiens	75-78
23624305-11	2013	Collectively, this study elucidates the bidirectional relationship between MPO and HOCl, which highlights the potential role of MPO as a source of free iron.	Iron	152-156	myeloperoxidase	Homo sapiens	128-131
23504952-7	2013	The cellular concentrations of iron were evaluated at 37 C or 4 C. (1) Transferrin-IONP-PLL uptake into cells was reliant on time and temperature.	Iron	31-35	transferrin	Homo sapiens	71-82
23228371-2	2013	This study analyzes the interference of copper, lead, iron and cadmium in acetylcholinesterase (AChE) and carboxylesterase (CbE) activities in zebrafish.	Iron	54-58	acetylcholinesterase	Danio rerio	74-94
23959272-0	2013	Binding of V(IV)O2+ to the Fe binding sites of human serum transferrin.	Iron	27-29	transferrin	Homo sapiens	59-70
23462098-3	2013	Instead of secreting siderophores to scavenge iron, Neisseria steal iron from human iron binding proteins such as hemoglobin, transferrin and lactoferrin for survival.	Iron	68-72	transferrin	Homo sapiens	126-137
23462098-3	2013	Instead of secreting siderophores to scavenge iron, Neisseria steal iron from human iron binding proteins such as hemoglobin, transferrin and lactoferrin for survival.	Iron	68-72	transferrin	Homo sapiens	126-137
23462098-5	2013	We also analyzed these proteins using small angle X-ray scattering and electron microscopy to provide the molecular details explaining how Neisseria are able to interact with and extract iron from transferrin.	Iron	187-191	transferrin	Homo sapiens	197-208
23462098-7	2013	We then analyzed these models to gain structural insights into the lactoferrin-iron import system and form a mechanistic model fashioned in parallel to the homologous transferrin-iron import system.	Iron	179-183	transferrin	Homo sapiens	167-178
23859830-5	2013	Preliminary works on complex formation equilibria of the first group of ligands with iron and aluminium highlighted extremely good pMe values and gave evidence of the ability to scavenge iron from inside cells.	Iron	85-89	cystatin B	Homo sapiens	131-134
23859830-5	2013	Preliminary works on complex formation equilibria of the first group of ligands with iron and aluminium highlighted extremely good pMe values and gave evidence of the ability to scavenge iron from inside cells.	Iron	187-191	cystatin B	Homo sapiens	131-134
23228371-2	2013	This study analyzes the interference of copper, lead, iron and cadmium in acetylcholinesterase (AChE) and carboxylesterase (CbE) activities in zebrafish.	Iron	54-58	acetylcholinesterase	Danio rerio	96-100
23670236-5	2013	It is also pointed out that insulin works by distributing iron to neuronal tissue and an insulin resistant state throws it off gear leading to iron overloading of neurons which is ultimately detrimental.	Iron	58-62	insulin	Homo sapiens	28-35
23506951-3	2013	In this study, we prepared magnetic nanoparticles with carbon-coated pure iron (Fe@C) acted as the core, Conjugating with EpCAM monoclonal antibody for immunomagnetic nanoparticles(IMPs).	Iron	74-78	epithelial cell adhesion molecule	Homo sapiens	122-127
23506951-3	2013	In this study, we prepared magnetic nanoparticles with carbon-coated pure iron (Fe@C) acted as the core, Conjugating with EpCAM monoclonal antibody for immunomagnetic nanoparticles(IMPs).	Iron	80-82	epithelial cell adhesion molecule	Homo sapiens	122-127
23670236-5	2013	It is also pointed out that insulin works by distributing iron to neuronal tissue and an insulin resistant state throws it off gear leading to iron overloading of neurons which is ultimately detrimental.	Iron	143-147	insulin	Homo sapiens	28-35
23670236-5	2013	It is also pointed out that insulin works by distributing iron to neuronal tissue and an insulin resistant state throws it off gear leading to iron overloading of neurons which is ultimately detrimental.	Iron	143-147	insulin	Homo sapiens	89-96
23926108-1	2013	Transferrin internalization via clathrin-mediated endocytosis and subsequent recycling after iron delivery has been extensively studied.	Iron	93-97	transferrin	Homo sapiens	0-11
23406462-5	2013	Cytoplasmic CD71 expression was largely negative in angiomatous meningioma cases, but positive in meningothelial and high-grade meningiomas, suggesting that the transferrin-dependent iron transporter was involved in iron uptake in meningiomas.	Iron	183-187	transferrin	Homo sapiens	161-172
23946113-0	2013	Aerobic iron-based cross-dehydrogenative coupling enables efficient diversity-oriented synthesis of coumestrol-based selective estrogen receptor modulators.	Iron	8-12	estrogen receptor 1	Homo sapiens	127-144
23946113-1	2013	An iron-based cross-dehydrogenative coupling (CDC) approach was applied for the diversity-oriented synthesis of coumestrol-based selective estrogen receptor modulators (SERMs), representing the first application of CDC chemistry in natural product synthesis.	Iron	3-7	estrogen receptor 1	Homo sapiens	139-156
23609990-1	2013	Alzheimer"s disease is the most common form of dementia in humans and is related to the accumulation of the amyloid-beta (Abeta) peptide and its interaction with metals (Cu, Fe, and Zn) in the brain.	Iron	174-176	amyloid beta precursor protein	Homo sapiens	122-127
23935105-5	2013	FANCJ belongs to a conserved iron-sulfur (Fe S) cluster family of helicases important for genomic stability including XPD (nucleotide excision repair), DDX11 (sister chromatid cohesion), and RTEL (telomere metabolism), genetically linked to xeroderma pigmentosum/Cockayne syndrome, Warsaw breakage syndrome, and dyskeratosis congenita, respectively.	Iron	29-33	DEAD/H-box helicase 11	Homo sapiens	152-157
23926108-6	2013	These are novel aspects of transferrin cell biology, which has previously considered only a degree of iron loading, but not other forms of heterogeneity.	Iron	102-106	transferrin	Homo sapiens	27-38
24012675-5	2013	Furthermore, the method of energy dispersive spectrum obtained through EM was analyzed to determine the elements carried by Spry2, and the results demonstrated that Spry2 is a silicon- and iron-containing protein.	Iron	189-193	sprouty RTK signaling antagonist 2	Homo sapiens	165-170
24065958-0	2013	Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon.	Iron	110-114	adiponectin, C1Q and collagen domain containing	Homo sapiens	28-39
24065958-7	2013	Differences in insulin levels between iron overload cases and controls were observed 2 h post-prandial, but not during the fasting state.	Iron	38-42	insulin	Homo sapiens	15-22
24066281-11	2013	Nramp1 and Nramp2 localization in distinct compartments suggests that both proteins synergistically regulate iron homeostasis.	Iron	109-113	solute carrier family 11 member 1	Homo sapiens	0-6
24066281-12	2013	Rather than by absorption via membrane transporters, iron is likely gained by degradation of ingested bacteria and efflux via Nramp1 from phagosomes to the cytosol.	Iron	53-57	solute carrier family 11 member 1	Homo sapiens	126-132
23850818-6	2013	Furthermore, the hepcidin, a key regulator of iron homeostasis was up-regulated by these iron liposomes, especially by HEME-LIP.	Iron	46-50	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
23850818-6	2013	Furthermore, the hepcidin, a key regulator of iron homeostasis was up-regulated by these iron liposomes, especially by HEME-LIP.	Iron	89-93	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
23850210-5	2013	The slopes of these correlations were similar for both iron and aluminum concentrations &lt;10.0 muM and at a wide pH range.	Iron	55-59	latexin	Homo sapiens	97-100
24046774-3	2013	Roots of soil-grown plants accumulate iron in the apoplast of the central cylinder, a pattern that is strongly intensified when the citrate effluxer FRD3 is not functional, thus stressing the importance of citrate in the apoplastic movement of Fe.	Iron	38-42	MATE efflux family protein	Arabidopsis thaliana	149-153
24040149-9	2013	Baseline serum iron (sFe) levels were higher in the smoke resistant group compared with the non-resistant group.	Iron	15-19	membrane metalloendopeptidase	Homo sapiens	21-24
24040149-13	2013	In addition, sFe levels were predictive for a decline in FEV1.Serum iron levels may be a biomarker for the spirometric susceptibility of individuals to cigarette smoke.	Iron	68-72	membrane metalloendopeptidase	Homo sapiens	13-16
23846167-3	2013	A potential reaction pathway starting with a direct hydride transfer from HCOO(-) to Fe is found to be possible, but slightly less favorable than the catalytic cycle with a beta-hydride elimination step.	Iron	85-87	amyloid beta precursor protein	Homo sapiens	171-177
24046774-3	2013	Roots of soil-grown plants accumulate iron in the apoplast of the central cylinder, a pattern that is strongly intensified when the citrate effluxer FRD3 is not functional, thus stressing the importance of citrate in the apoplastic movement of Fe.	Iron	244-246	MATE efflux family protein	Arabidopsis thaliana	149-153
23836816-0	2013	Conserved regions of gonococcal TbpB are critical for surface exposure and transferrin iron utilization.	Iron	87-91	transferrin	Homo sapiens	75-86
23475935-2	2013	Non-transferrin bound iron (NTBI) may contribute to TRIM by promoting oxidative damage and pro-inflammatory cytokine release.	Iron	22-26	transferrin	Homo sapiens	4-15
23416443-8	2013	In fact, the heme reactivity of CYGB depends on the lipid, such as oleate, binding which stabilizes the penta-coordination geometry of the heme-Fe atom.	Iron	144-146	cytoglobin	Homo sapiens	32-36
23416443-9	2013	Lastly, the reactivity of NGB and CYGB is modulated by the redox state of the intramolecular CysCD7/CysD5 and CysB2/CysE9 residue pairs, respectively, affecting the heme-Fe atom coordination state.	Iron	170-172	cytoglobin	Homo sapiens	34-38
23212531-10	2013	CONCLUSION: In this pooled analysis, cow"s milk intake in late infancy associated negatively, and follow-on formula positively, with iron status.	Iron	133-137	Weaning weight-maternal milk	Bos taurus	43-47
23909240-4	2013	Further, we demonstrate that His86 in this N-terminal region is required for high affinity iron coordination and iron assembly of Fe-S clusters by ISCU as part of the Fe-S cluster biosynthetic complex.	Iron	91-95	iron-sulfur cluster assembly enzyme	Homo sapiens	147-151
23909240-4	2013	Further, we demonstrate that His86 in this N-terminal region is required for high affinity iron coordination and iron assembly of Fe-S clusters by ISCU as part of the Fe-S cluster biosynthetic complex.	Iron	113-117	iron-sulfur cluster assembly enzyme	Homo sapiens	147-151
23909240-4	2013	Further, we demonstrate that His86 in this N-terminal region is required for high affinity iron coordination and iron assembly of Fe-S clusters by ISCU as part of the Fe-S cluster biosynthetic complex.	Iron	130-134	iron-sulfur cluster assembly enzyme	Homo sapiens	147-151
23909240-4	2013	Further, we demonstrate that His86 in this N-terminal region is required for high affinity iron coordination and iron assembly of Fe-S clusters by ISCU as part of the Fe-S cluster biosynthetic complex.	Iron	167-171	iron-sulfur cluster assembly enzyme	Homo sapiens	147-151
23772810-12	2013	Excessive iron could also induce apoptosis, arrest cell cycle, and decrease function of BMMNC and UC-MSC, which was accompanied by increased ROS level and stimulated p38MAPK, p53 signaling pathway.	Iron	10-14	tumor protein p53	Homo sapiens	175-178
23836816-1	2013	The transferrin-binding proteins TbpA and TbpB enable Neisseria gonorrhoeae to obtain iron from human transferrin.	Iron	86-90	transferrin	Homo sapiens	4-15
23836816-1	2013	The transferrin-binding proteins TbpA and TbpB enable Neisseria gonorrhoeae to obtain iron from human transferrin.	Iron	86-90	transferrin	Homo sapiens	102-113
23836816-9	2013	When these mutant TbpB proteins were produced in a strain expressing a form of TbpA that requires TbpB for iron acquisition, growth on transferrin was either abrogated or dramatically diminished.	Iron	107-111	transferrin	Homo sapiens	135-146
23836816-10	2013	We conclude that surface tethering of TbpB is required for optimal performance of the transferrin iron acquisition system, while the presence of the polyglycine stretch near the amino terminus of TbpB contributes significantly to transferrin iron transport function.	Iron	98-102	transferrin	Homo sapiens	86-97
23836816-10	2013	We conclude that surface tethering of TbpB is required for optimal performance of the transferrin iron acquisition system, while the presence of the polyglycine stretch near the amino terminus of TbpB contributes significantly to transferrin iron transport function.	Iron	242-246	transferrin	Homo sapiens	86-97
23836816-10	2013	We conclude that surface tethering of TbpB is required for optimal performance of the transferrin iron acquisition system, while the presence of the polyglycine stretch near the amino terminus of TbpB contributes significantly to transferrin iron transport function.	Iron	242-246	transferrin	Homo sapiens	230-241
23787140-1	2013	HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1alpha.	Iron	48-50	egl-9 family hypoxia inducible factor 1	Homo sapiens	28-32
23787140-1	2013	HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD) of HIF-1alpha.	Iron	48-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	304-314
23660068-6	2013	We also demonstrate that the ability of ciclopirox to inhibit mTOR is specific to ciclopirox because neither iron chelators nor other eIF5A inhibitors affect mTOR activity, even at high doses.	Iron	109-113	mechanistic target of rapamycin kinase	Homo sapiens	62-66
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	180-184	transmembrane serine protease 6	Homo sapiens	41-48
23794717-0	2013	Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.	Iron	56-60	transmembrane serine protease 6	Homo sapiens	43-50
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	180-184	transmembrane serine protease 6	Homo sapiens	95-102
23794717-1	2013	BACKGROUND: Genome-wide association studies have convincingly shown that single nucleotide polymorphisms (SNPs) in HFE and TMPRSS6 are associated with iron parameters.	Iron	151-155	transmembrane serine protease 6	Homo sapiens	123-130
23794717-11	2013	Taken together, this suggests that there might be other, yet unknown, serum hepcidin independent mechanisms which play a role in the association of HFE and TMPRSS6 variants with serum iron parameters.	Iron	184-188	transmembrane serine protease 6	Homo sapiens	156-163
23794717-4	2013	We report here the second study to investigate the role of hepcidin in the associations between common variants in HFE and TMPRSS6 with iron parameters.	Iron	136-140	transmembrane serine protease 6	Homo sapiens	123-130
23685131-3	2013	Although iron affects beta-amyloid precursor protein (APP) expression and Abeta deposition, detailed role of iron in AD requires further elucidation.	Iron	9-13	amyloid beta precursor protein	Homo sapiens	22-52
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	130-134	transmembrane serine protease 6	Homo sapiens	41-48
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	130-134	transmembrane serine protease 6	Homo sapiens	95-102
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	130-134	transferrin	Homo sapiens	146-157
24382527-0	2013	Is the acronym IRIDA acceptable for slow responders to iron in the presence of TMPRSS6 mutations?	Iron	55-59	transmembrane serine protease 6	Homo sapiens	79-86
24382527-1	2013	Iron refractory iron deficiency anemia (IRIDA) is a recently described autosomal recessive disorder caused by mutations in TMPRSS6, the gene encoding matriptase-2.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	123-130
24382527-1	2013	Iron refractory iron deficiency anemia (IRIDA) is a recently described autosomal recessive disorder caused by mutations in TMPRSS6, the gene encoding matriptase-2.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	150-162
23643526-12	2013	24h after 1Gy of Fe particles exposure, the yield of MN increased, and the majority (~70%) carried gammaH2AX and Smad7.	Iron	17-19	SMAD family member 7	Homo sapiens	113-118
25340139-5	2013	Also a significant positive correlation between serum CRP and serum iron (r=0.44, p=0.008) (adjusted for age too) was observed.	Iron	68-72	C-reactive protein	Homo sapiens	54-57
23846698-0	2013	Hepcidin bound to alpha2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels.	Iron	116-120	alpha-2-macroglobulin	Mus musculus	18-38
23846698-1	2013	Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1).	Iron	19-23	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	54-67
23846698-1	2013	Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1).	Iron	19-23	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-73
23846698-10	2013	However, serum iron levels were reduced to a significantly greater extent in mice treated with alpha2M hepcidin or alpha2M-MA hepcidin relative to unbound hepcidin.	Iron	15-19	alpha-2-macroglobulin	Mus musculus	95-102
23846698-10	2013	However, serum iron levels were reduced to a significantly greater extent in mice treated with alpha2M hepcidin or alpha2M-MA hepcidin relative to unbound hepcidin.	Iron	15-19	alpha-2-macroglobulin	Mus musculus	115-122
23990614-0	2013	A translational link between Fe and Epo.	Iron	29-31	erythropoietin	Homo sapiens	36-39
23940258-6	2013	Increased iron incorporation into the FtH homopolymer leads to reduced cellular iron availability, diminished levels of cytosolic catalase, SOD1 protein levels, enhanced ROS production and higher levels of oxidized proteins.	Iron	10-14	superoxide dismutase 1	Homo sapiens	140-144
23836059-10	2013	Ab-mediated blockade of hepcidin partially reversed the effects on iron biology caused by IL-22R stimulation.	Iron	67-71	interleukin 22 receptor, alpha 1	Mus musculus	90-96
23182005-0	2013	Effects of erythropoietin administration on iron status in patients with ST-elevation myocardial infarction who underwent successful percutaneous coronary intervention.	Iron	44-48	erythropoietin	Homo sapiens	11-25
23820077-6	2013	Studies in inducible nitric oxide synthase (iNOS(-/-))-deficient mice revealed that inducible nitric oxide synthase mediates oxidation of erythrocyte lysis-derived iron to paramagnetic Fe3+, which causes thrombus T1 relaxation time shortening.	Iron	164-168	nitric oxide synthase 2, inducible	Mus musculus	11-42
23883622-1	2013	Transferrin (Tf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells, was chosen as the ligand to develop Tf-conjugated PEGylated nanoscaled graphene oxide (GO) for loading and glioma targeting delivery of anticancer drug doxorubicin (Dox) (Tf-PEG-GO-Dox).	Iron	21-25	transferrin	Rattus norvegicus	0-11
23883622-1	2013	Transferrin (Tf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells, was chosen as the ligand to develop Tf-conjugated PEGylated nanoscaled graphene oxide (GO) for loading and glioma targeting delivery of anticancer drug doxorubicin (Dox) (Tf-PEG-GO-Dox).	Iron	21-25	transferrin	Rattus norvegicus	13-15
23883622-1	2013	Transferrin (Tf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells, was chosen as the ligand to develop Tf-conjugated PEGylated nanoscaled graphene oxide (GO) for loading and glioma targeting delivery of anticancer drug doxorubicin (Dox) (Tf-PEG-GO-Dox).	Iron	21-25	transferrin	Rattus norvegicus	164-166
23793053-3	2013	On heating compounds 1-3 in a thermobalance new coordination polymers of composition M(NCS)2(2-methylpyrazine)2 (M = Co (4-Co) , Fe (4-Fe)) are obtained in the first step, which transform into M(NCS)2(2-methylpyrazine) (M = Co (5-Co) , Fe (5-Fe)) in the second.	Iron	129-131	cytosolic thiouridylase subunit 2	Homo sapiens	87-92
23820077-6	2013	Studies in inducible nitric oxide synthase (iNOS(-/-))-deficient mice revealed that inducible nitric oxide synthase mediates oxidation of erythrocyte lysis-derived iron to paramagnetic Fe3+, which causes thrombus T1 relaxation time shortening.	Iron	164-168	nitric oxide synthase 2, inducible	Mus musculus	84-115
23788639-0	2013	Arabidopsis ferritin 1 (AtFer1) gene regulation by the phosphate starvation response 1 (AtPHR1) transcription factor reveals a direct molecular link between iron and phosphate homeostasis.	Iron	157-161	ferretin 1	Arabidopsis thaliana	24-30
23891004-0	2013	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	Iron	46-50	cytosolic iron-sulfur assembly component 2A	Homo sapiens	6-18
23891004-0	2013	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	Iron	120-124	cytosolic iron-sulfur assembly component 2A	Homo sapiens	6-18
23891004-5	2013	In contrast, CIA2A specifically matures iron regulatory protein 1 (IRP1), which is critical for cellular iron homeostasis.	Iron	40-44	cytosolic iron-sulfur assembly component 2A	Homo sapiens	13-18
23891004-6	2013	Surprisingly, a second layer of iron regulation involves the stabilization of IRP2 by CIA2A binding or upon depletion of CIA2B or MMS19, even though IRP2 lacks an Fe/S cluster.	Iron	32-36	iron responsive element binding protein 2	Homo sapiens	78-82
23891004-6	2013	Surprisingly, a second layer of iron regulation involves the stabilization of IRP2 by CIA2A binding or upon depletion of CIA2B or MMS19, even though IRP2 lacks an Fe/S cluster.	Iron	32-36	cytosolic iron-sulfur assembly component 2A	Homo sapiens	86-91
23891004-6	2013	Surprisingly, a second layer of iron regulation involves the stabilization of IRP2 by CIA2A binding or upon depletion of CIA2B or MMS19, even though IRP2 lacks an Fe/S cluster.	Iron	32-36	iron responsive element binding protein 2	Homo sapiens	149-153
23891004-7	2013	In summary, CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization.	Iron	140-144	iron responsive element binding protein 2	Homo sapiens	193-197
23935582-0	2013	Effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimer"s and Parkinson"s diseases.	Iron	72-76	transferrin	Homo sapiens	31-42
23721262-4	2013	We have shown that trivalent iron (FeIII) initiates a hydroxyl radical-catalyzed conversion of fibrinogen into a fibrin-like polymer (parafibrin) that is remarkably resistant to the proteolytic dissolution and thus promotes its intravascular deposition.	Iron	29-33	fibrinogen beta chain	Homo sapiens	95-105
23583428-5	2013	Our data confirm that the main source of iron is the non-transferrin-bound iron (NTBI) and show the involvement of two different routes for its entry: the resident transient receptor potential (TRP) channels in quiescent astrocytes and the de novo expressed divalent metal transporter 1 (DMT1) in activated astrocytes, which accounts for a potentiation of iron entry.	Iron	41-45	transferrin	Homo sapiens	57-68
23583428-5	2013	Our data confirm that the main source of iron is the non-transferrin-bound iron (NTBI) and show the involvement of two different routes for its entry: the resident transient receptor potential (TRP) channels in quiescent astrocytes and the de novo expressed divalent metal transporter 1 (DMT1) in activated astrocytes, which accounts for a potentiation of iron entry.	Iron	75-79	transferrin	Homo sapiens	57-68
23583428-5	2013	Our data confirm that the main source of iron is the non-transferrin-bound iron (NTBI) and show the involvement of two different routes for its entry: the resident transient receptor potential (TRP) channels in quiescent astrocytes and the de novo expressed divalent metal transporter 1 (DMT1) in activated astrocytes, which accounts for a potentiation of iron entry.	Iron	75-79	transferrin	Homo sapiens	57-68
23598047-4	2013	Deferoxamine (DFO) is an angiogenic activator that triggers the HIF-1alpha pathway through localized iron depletion.	Iron	101-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
23648413-0	2013	Transferrin receptor-1 iron-acquisition pathway - synthesis, kinetics, thermodynamics and rapid cellular internalization of a holotransferrin-maghemite nanoparticle construct.	Iron	23-27	transferrin	Homo sapiens	0-11
23648413-1	2013	BACKGROUND: Targeting nanoobjects via the iron-acquisition pathway is always reported slower than the transferrin/receptor endocytosis.	Iron	42-46	transferrin	Homo sapiens	102-113
23721262-6	2013	We study the effects of certain amphiphilic substances on the iron- and thrombin-induced fibrinogen polymerization visualized using scanning electron microscopy.	Iron	62-66	fibrinogen beta chain	Homo sapiens	89-99
23757263-4	2013	New subtypes of neuronal brain iron accumulation have been delineated and linked to mutations in C19orf12 and WDR45, while a new treatable form of dystonia with brain manganese deposition related to mutations in SLC30A10 has been described.	Iron	31-35	WD repeat domain 45	Homo sapiens	110-115
23791636-0	2013	Specific roles for Group V secretory PLA2 in retinal iron-induced oxidative stress.	Iron	53-57	phospholipase A2 group VI	Homo sapiens	37-41
23791636-6	2013	We found that sPLA2 is localized in cytosolic fraction in an iron concentration-dependent manner.	Iron	61-65	phospholipase A2 group X	Homo sapiens	14-19
23791636-10	2013	In the presence of ATK (cPLA2 inhibitor) and YM 26734 (sPLA2 inhibitor), the nuclear localization of both p65 and p50 NF-kappaB subunits was restored to control levels in retinas exposed to iron-induced oxidative stress.	Iron	190-194	phospholipase A2 group X	Homo sapiens	55-60
23791636-7	2013	By immunoprecipitation (IP) assays we also demonstrated an increased association between Group V sPLA2 and COX-2 in retinas exposed to iron overload.	Iron	135-139	phospholipase A2 group X	Homo sapiens	97-102
23791636-10	2013	In the presence of ATK (cPLA2 inhibitor) and YM 26734 (sPLA2 inhibitor), the nuclear localization of both p65 and p50 NF-kappaB subunits was restored to control levels in retinas exposed to iron-induced oxidative stress.	Iron	190-194	nuclear factor kappa B subunit 1	Homo sapiens	114-117
23791636-7	2013	By immunoprecipitation (IP) assays we also demonstrated an increased association between Group V sPLA2 and COX-2 in retinas exposed to iron overload.	Iron	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
23791636-10	2013	In the presence of ATK (cPLA2 inhibitor) and YM 26734 (sPLA2 inhibitor), the nuclear localization of both p65 and p50 NF-kappaB subunits was restored to control levels in retinas exposed to iron-induced oxidative stress.	Iron	190-194	nuclear factor kappa B subunit 1	Homo sapiens	118-127
23791636-9	2013	p65 (RelA) NF-kappaB levels were increased in nuclear fractions from retinas exposed to iron.	Iron	88-92	nuclear factor kappa B subunit 1	Homo sapiens	11-20
23791636-13	2013	The use of PLA2 inhibitors demonstrated that PS is actively deacylated during iron-induced oxidative stress.	Iron	78-82	phospholipase A2 group VI	Homo sapiens	11-15
23791636-14	2013	Results from the present study suggest that Group V sPLA2 has multiple intracellular targets during iron-induced retinal degeneration and that the specific role of sPLA2 could be related to inflammatory responses by its participation in NF-kappaB and COX-2 regulation.	Iron	100-104	phospholipase A2 group X	Homo sapiens	52-57
23779234-2	2013	The proposed mechanism of this molybdenum cofactor dependent enzyme involves two one-electron intramolecular electron transfer (IET) steps from the molybdenum center to the iron of the b 5-type heme and two one-electron intermolecular electron transfer steps from the heme to cytochrome c.	Iron	173-177	cytochrome c, somatic	Homo sapiens	276-288
23506423-3	2013	In this study, we analyzed the effects of the inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) and of lipopolysaccharide on total cell iron content and on the expression and abundance of the iron transporters divalent metal transporter 1 (DMT1) and Ferroportin 1 (FPN1) in neurons, astrocytes and microglia obtained from rat brain.	Iron	174-178	tumor necrosis factor	Rattus norvegicus	69-96
23788722-5	2013	In iron deficiency, GSH and ASC increased the activity of the heme protein ascorbate peroxidase at a similar level to that found in iron-sufficient seedlings.	Iron	3-7	peroxidase	Arabidopsis thaliana	85-95
23849154-2	2013	We explore these two approaches in a study of intravenous iron use in hemodialysis patients treated concurrently with epoetin alfa (EPO).	Iron	58-62	erythropoietin	Homo sapiens	118-125
23849154-2	2013	We explore these two approaches in a study of intravenous iron use in hemodialysis patients treated concurrently with epoetin alfa (EPO).	Iron	58-62	erythropoietin	Homo sapiens	132-135
23506423-4	2013	Considering previous reports indicating that inflammatory stimuli induce the systemic synthesis of the master iron regulator hepcidin, we identified brain cells that produce hepcidin in response to inflammatory stimuli, as well as hepcidin-target cells.	Iron	110-114	hepcidin antimicrobial peptide	Rattus norvegicus	125-133
23452586-4	2013	Iron status was assessed at the end of the study by measurements of hemoglobin, serum ferritin, and soluble transferrin receptor levels.	Iron	0-4	transferrin	Homo sapiens	108-119
23506423-4	2013	Considering previous reports indicating that inflammatory stimuli induce the systemic synthesis of the master iron regulator hepcidin, we identified brain cells that produce hepcidin in response to inflammatory stimuli, as well as hepcidin-target cells.	Iron	110-114	hepcidin antimicrobial peptide	Rattus norvegicus	174-182
23506423-4	2013	Considering previous reports indicating that inflammatory stimuli induce the systemic synthesis of the master iron regulator hepcidin, we identified brain cells that produce hepcidin in response to inflammatory stimuli, as well as hepcidin-target cells.	Iron	110-114	hepcidin antimicrobial peptide	Rattus norvegicus	174-182
23506423-9	2013	The data presented here establish for the first time a causal association between inflammation and iron accumulation in brain cells, probably promoted by changes in DMT1 and FPN1 expression and mediated in part by hepcidin.	Iron	99-103	solute carrier family 40 member 1	Rattus norvegicus	174-178
23506423-9	2013	The data presented here establish for the first time a causal association between inflammation and iron accumulation in brain cells, probably promoted by changes in DMT1 and FPN1 expression and mediated in part by hepcidin.	Iron	99-103	hepcidin antimicrobial peptide	Rattus norvegicus	214-222
23305102-1	2013	BACKGROUND: Pica and restless legs syndrome (RLS) are associated with iron depletion and deficiency.	Iron	70-74	RLS1	Homo sapiens	45-48
24052985-3	2013	The aim of the study was the evaluation of serum iron parameters in patients with different chronic liver diseases and analysis of the relationships between serum level of iron, ferritin and transferrin in women and men in groups examined.	Iron	172-176	transferrin	Homo sapiens	191-202
23651775-1	2013	Trivalent metal ion (Al, Cr, Fe) doped potassium hydrogen phthalate (KAP) crystals have been grown from aqueous solution at room temperature.	Iron	29-31	napsin A aspartic peptidase	Homo sapiens	69-72
23305102-11	2013	RLS was reported in 16% of subjects with iron depletion or deficiency compared with 11% of iron-replete donors (p = 0.012).	Iron	41-45	RLS1	Homo sapiens	0-3
23305102-12	2013	Iron replacement generally resulted in improvement of RLS symptoms; however, at least 4 to 6 weeks of iron therapy was necessary.	Iron	0-4	RLS1	Homo sapiens	54-57
23998614-6	2013	By analyzing the proteins involved in cellular iron metabolism, MDS erythroid cells present an "iron-loaded" phenotype characterized by increased ferritin contents and reduced transferrin receptor, which reflects the degree of dysplasia assessed by morphology.	Iron	96-100	transferrin	Homo sapiens	176-187
23571113-5	2013	The results indicated that the Fe-Cu binary oxide with a Cu: Fe molar ratio of 1:2 had excellent performance in removing both As(V) and As(III) from water, and the maximal adsorption capacities for As(V) and As(III) were 82.7 and 122.3 mg/g at pH 7.0, respectively.	Iron	31-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	126-131
23571113-5	2013	The results indicated that the Fe-Cu binary oxide with a Cu: Fe molar ratio of 1:2 had excellent performance in removing both As(V) and As(III) from water, and the maximal adsorption capacities for As(V) and As(III) were 82.7 and 122.3 mg/g at pH 7.0, respectively.	Iron	31-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	198-203
23723143-0	2013	Adiponectin ameliorates iron-overload cardiomyopathy through the PPARalpha-PGC-1-dependent signaling pathway.	Iron	24-28	peroxisome proliferator activated receptor alpha	Mus musculus	65-74
23723143-7	2013	In addition, AAV-ADIPOQ-treated iron-overload mice had lower expression of inflammatory markers, including myeloperoxidase activity, monocyte chemotactic protein-1, tumor necrosis factor-alpha, interleukin-6, and intercellular adhesion molecule-1, than iron-overloaded mice not treated with AAV-ADIPOQ.	Iron	32-36	interleukin 6	Mus musculus	194-207
23723143-9	2013	Furthermore, the adiponectin-mediated beneficial effects were PPARalpha-dependent as the adiponectin-mediated attenuation of iron deposition was abolished in PPARalpha-knockout mice.	Iron	125-129	peroxisome proliferator activated receptor alpha	Mus musculus	62-71
23723143-9	2013	Furthermore, the adiponectin-mediated beneficial effects were PPARalpha-dependent as the adiponectin-mediated attenuation of iron deposition was abolished in PPARalpha-knockout mice.	Iron	125-129	peroxisome proliferator activated receptor alpha	Mus musculus	158-167
23723143-11	2013	Together, these findings suggest that adiponectin acts as an anti-inflammatory signaling molecule and induces the expression of HO-1 through the PPARalpha-PGC-1 complex-dependent pathway in cardiomyocytes, resulting in the attenuation of iron-induced cardiomyopathy.	Iron	238-242	heme oxygenase 1	Mus musculus	128-132
22277574-4	2013	Histological examination showed that pioglitazone reduced the area of cardiac fibrosis and iron deposition in the heart of angiotensin II-treated rats.	Iron	91-95	angiotensinogen	Rattus norvegicus	123-137
23740424-1	2013	As part of a program aimed at making bifunctional iron(II) spin-crossover (SCO) materials, particularly those having redox/electron transfer as the second function, we have made the new ferrocene-triazole ligand ATF ([(4H-1,2,4-triazol-4-yl)amino]methylferrocene), (1), and a series of M(II) complexes of this ligand with emphasis on iron(II).	Iron	50-54	glial cell derived neurotrophic factor	Homo sapiens	212-215
23935819-1	2013	We reported that iron influx drives the translational expression of the neuronal amyloid precursor protein (APP), which has a role in iron efflux.	Iron	17-21	amyloid beta precursor protein	Homo sapiens	81-106
23935819-1	2013	We reported that iron influx drives the translational expression of the neuronal amyloid precursor protein (APP), which has a role in iron efflux.	Iron	134-138	amyloid beta precursor protein	Homo sapiens	81-106
23796308-3	2013	Recent reports have highlighted the existence of structural flexibility in the ISU/IscU-type scaffold proteins that mediate Fe-S cluster assembly, which is also likely to serve an important role in the pathway to Fe-S cluster maturation.	Iron	124-128	iron-sulfur cluster assembly enzyme	Homo sapiens	83-87
23796308-3	2013	Recent reports have highlighted the existence of structural flexibility in the ISU/IscU-type scaffold proteins that mediate Fe-S cluster assembly, which is also likely to serve an important role in the pathway to Fe-S cluster maturation.	Iron	213-217	iron-sulfur cluster assembly enzyme	Homo sapiens	83-87
23898337-4	2013	This review focuses on the new actors discovered in the past few years, such as glutaredoxin, BOLA and NEET proteins as well as MIP18, MMS19, TAH18, DRE2 for the cytosolic machinery, which are integrated into a model for the plant Fe-S cluster biogenesis systems.	Iron	231-235	cytokine induced apoptosis inhibitor 1	Homo sapiens	149-153
23866833-13	2013	High levels of circulating iron measured by transferrin saturation are associated with increased oxidative stress in women however its association with the higher levels of serum ferritin is controversial.	Iron	27-31	transferrin	Homo sapiens	44-55
23870268-5	2013	This inhibitory mechanism is different from the iron-sequestration model, but it is qualitatively similar to a mechanism previously proposed for the inhibition of Abeta self-association by another plasma and cerebrospinal fluid protein, i.e., human serum albumin.	Iron	48-52	amyloid beta precursor protein	Homo sapiens	163-168
24223452-3	2013	The starting point is in the characterization of the reduced heme complexes, [(F8)FeII], [(PPy)FeII] and [(PIm)FeII], where F8, PPy and PIm are iron(II)-porphyrinates and where PPy and PIm possess a covalently tethered axial base pyridyl or imidazolyl group, respectively.	Iron	144-148	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	107-110
24223452-3	2013	The starting point is in the characterization of the reduced heme complexes, [(F8)FeII], [(PPy)FeII] and [(PIm)FeII], where F8, PPy and PIm are iron(II)-porphyrinates and where PPy and PIm possess a covalently tethered axial base pyridyl or imidazolyl group, respectively.	Iron	144-148	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	136-139
24223452-3	2013	The starting point is in the characterization of the reduced heme complexes, [(F8)FeII], [(PPy)FeII] and [(PIm)FeII], where F8, PPy and PIm are iron(II)-porphyrinates and where PPy and PIm possess a covalently tethered axial base pyridyl or imidazolyl group, respectively.	Iron	144-148	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	136-139
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	113-117	iron-sulfur cluster assembly enzyme	Homo sapiens	255-259
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	185-189	iron-sulfur cluster assembly enzyme	Homo sapiens	255-259
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	185-189	iron-sulfur cluster assembly enzyme	Homo sapiens	255-259
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	185-189	iron-sulfur cluster assembly enzyme	Homo sapiens	255-259
23417759-1	2013	Transfusion dependence in myelodysplastic syndrome (MDS) patients may lead to organ damage due to accumulation of non-transferrin-bound iron with consequent increased oxidative stress.	Iron	136-140	transferrin	Homo sapiens	118-129
23687303-0	2013	Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress.	Iron	118-122	thymoma viral proto-oncogene 1	Mus musculus	46-49
23687303-2	2013	The aim of this work was to investigate the participation of the PI3K/Akt pathway and its outcome on different molecular targets such as glycogen synthase kinase 3beta (GSK3beta) and Forkhead box-O (FoxO) transcription factors during mild oxidative stress triggered by iron overload.	Iron	269-273	thymoma viral proto-oncogene 1	Mus musculus	70-73
23687303-7	2013	Iron-overloaded cells harboring a constitutively active form of Akt showed decreased oxidants levels.	Iron	0-4	thymoma viral proto-oncogene 1	Mus musculus	64-67
23687303-9	2013	Our results show that activation of the PI3K/Akt pathway during iron-induced neurotoxicity regulates multiple targets such as GSK3beta, FoxO transcriptional activity, and glutathione metabolism, thus modulating the neuronal response to oxidative stress.	Iron	64-68	thymoma viral proto-oncogene 1	Mus musculus	45-48
23756812-4	2013	Here, we present a biochemical and biophysical characterization of zebrafish glutaredoxin 2, focusing on iron-sulfur-cluster coordination.	Iron	105-109	glutaredoxin 2	Danio rerio	77-91
23633457-6	2013	Increased fumarate and decreased iron levels in FH-deficient kidney cancer cells inactivate prolyl hydroxylases, leading to stabilization of hypoxia-inducible factor (HIF)-1alpha and increased expression of genes such as VEGF and glucose transporter 1 (GLUT1) to provide fuel needed for rapid growth demands.	Iron	33-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-178
23361852-0	2013	DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system.	Iron	46-50	transferrin	Rattus norvegicus	28-39
23361852-3	2013	Since iron elicits its effect in a transferrin (Tf)-free environment, in this work we postulate that non-transferrin-bound iron (NTBI) uptake must be involved.	Iron	6-10	transferrin	Rattus norvegicus	35-46
23361852-3	2013	Since iron elicits its effect in a transferrin (Tf)-free environment, in this work we postulate that non-transferrin-bound iron (NTBI) uptake must be involved.	Iron	6-10	transferrin	Rattus norvegicus	48-50
23361852-3	2013	Since iron elicits its effect in a transferrin (Tf)-free environment, in this work we postulate that non-transferrin-bound iron (NTBI) uptake must be involved.	Iron	6-10	transferrin	Rattus norvegicus	105-116
23361852-3	2013	Since iron elicits its effect in a transferrin (Tf)-free environment, in this work we postulate that non-transferrin-bound iron (NTBI) uptake must be involved.	Iron	60-64	transferrin	Rattus norvegicus	48-50
23658396-8	2013	This association was significant with respect to the risk of ER-positive cancer (IRR: 1.11; 1.01-1.23) and among women not using HRT (IRR: 1.11; 0.97-1.26) or with low dietary iron intake (IRR: 1.10; 1.06-1.37 per unit increase) for all breast cancer.	Iron	176-180	estrogen receptor 1	Homo sapiens	61-63
23633457-6	2013	Increased fumarate and decreased iron levels in FH-deficient kidney cancer cells inactivate prolyl hydroxylases, leading to stabilization of hypoxia-inducible factor (HIF)-1alpha and increased expression of genes such as VEGF and glucose transporter 1 (GLUT1) to provide fuel needed for rapid growth demands.	Iron	33-37	vascular endothelial growth factor A	Homo sapiens	221-225
23369046-13	2013	Clinicians should have a high suspicion for the presence of RLS symptoms in patients with ESRD, especially those with type 2 diabetes, anemia, low serum iron status and long duration of dialysis.	Iron	153-157	RLS1	Homo sapiens	60-63
23515442-7	2013	Iron activated AMPK by increasing deacetylase and decreasing LKB1 acetylation, in turn stimulating the phosphorylation of LKB1 and AMPK.	Iron	0-4	serine/threonine kinase 11	Mus musculus	61-65
23515442-7	2013	Iron activated AMPK by increasing deacetylase and decreasing LKB1 acetylation, in turn stimulating the phosphorylation of LKB1 and AMPK.	Iron	0-4	serine/threonine kinase 11	Mus musculus	122-126
23349308-2	2013	These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during iron overload.	Iron	76-80	transferrin	Rattus norvegicus	58-69
23180123-1	2013	The ferric uptake regulator gene (fur), its promoter region and Fur box of pvdS gene involved in siderophore-mediated iron uptake system were sequenced in the parent strain Pseudomonas aeruginosa PAO1 and in the fur mutant FPA121 derived from the strain PAO1.	Iron	118-122	ferric uptake regulation protein	Pseudomonas aeruginosa PAO1	34-37
23180123-4	2013	The amino acid replacement in the regulatory Fur protein is responsible for the overproduction of pyoverdine in iron-deplete and iron-replete medium.	Iron	112-116	ferric uptake regulation protein	Pseudomonas aeruginosa PAO1	45-48
23180123-4	2013	The amino acid replacement in the regulatory Fur protein is responsible for the overproduction of pyoverdine in iron-deplete and iron-replete medium.	Iron	129-133	ferric uptake regulation protein	Pseudomonas aeruginosa PAO1	45-48
23349308-2	2013	These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during iron overload.	Iron	29-33	transferrin	Rattus norvegicus	39-50
23349308-3	2013	Here, we assessed the effect of iron status on the levels of the transmembrane transporters, ZRT/IRT-like protein 14 and divalent metal-ion transporter-1, which have both been implicated in transferrin- and non-transferrin-bound iron uptake.	Iron	32-36	transferrin	Rattus norvegicus	190-201
23349308-2	2013	These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during iron overload.	Iron	76-80	transferrin	Rattus norvegicus	58-69
23349308-3	2013	Here, we assessed the effect of iron status on the levels of the transmembrane transporters, ZRT/IRT-like protein 14 and divalent metal-ion transporter-1, which have both been implicated in transferrin- and non-transferrin-bound iron uptake.	Iron	32-36	transferrin	Rattus norvegicus	211-222
23349308-3	2013	Here, we assessed the effect of iron status on the levels of the transmembrane transporters, ZRT/IRT-like protein 14 and divalent metal-ion transporter-1, which have both been implicated in transferrin- and non-transferrin-bound iron uptake.	Iron	229-233	transferrin	Rattus norvegicus	211-222
23519527-4	2013	Thermal denaturation study of DNA with complex revealed the DeltaTm of 5  C. Competitive binding study shows that the enhanced emission intensity of ethidium bromide (EB) in the presence of DNA was quenched by adding of the iron complex indicating that it displaces EB from its binding site in DNA and the apparent binding constant has been estimated to be 5 x 10(6) muM(-1).	Iron	224-228	PWWP domain containing 3A, DNA repair factor	Bos taurus	367-373
23811695-5	2013	The TaLls1 protein contains a conserved Rieske [2Fe-2S] motif and a mononuclear iron-binding site typical of PaOs.	Iron	80-84	pheophorbide a oxygenase, chloroplastic	Triticum aestivum	4-10
23606747-1	2013	The transferrin receptor (TfR) mediates the uptake of transferrin (Tf)-bound iron from the plasma into the cells of peripheral tissues.	Iron	77-81	transferrin	Homo sapiens	4-15
23670084-2	2013	In patients with kidney diseases, renal tubules are exposed to a high concentration of iron owing to increased glomerular filtration of iron and iron-containing proteins, including haemoglobin, transferrin and neutrophil gelatinase-associated lipocalin (NGAL).	Iron	87-91	transferrin	Homo sapiens	194-205
23345622-0	2013	A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.	Iron	36-40	hepcidin antimicrobial peptide	Rattus norvegicus	2-10
23184650-0	2013	Akt/Nrf2 activated upregulation of heme oxygenase-1 involves in the role of Rg1 against ferrous iron-induced neurotoxicity in SK-N-SH cells.	Iron	96-100	AKT serine/threonine kinase 1	Homo sapiens	0-3
23345622-8	2013	CONCLUSIONS: Our data suggest that hepcidin lowering agents may provide a new therapeutic strategy to improve iron availability for erythropoiesis in CKD.	Iron	110-114	hepcidin antimicrobial peptide	Rattus norvegicus	35-43
23982533-8	2013	It is evident from the study that body iron (serum iron, TIBC &amp; transferrin saturation) level significantly increases among acute myocardial infarction patients in Bangladesh.	Iron	39-43	transferrin	Homo sapiens	68-79
23184650-0	2013	Akt/Nrf2 activated upregulation of heme oxygenase-1 involves in the role of Rg1 against ferrous iron-induced neurotoxicity in SK-N-SH cells.	Iron	96-100	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
23184650-4	2013	Significant rescue of Rg1 on cell viability against 100 muM ferrous iron-induced neurotoxicity was observed.	Iron	60-72	latexin	Homo sapiens	56-59
23184650-8	2013	These results suggest that the neuroprotective effects of Rg1 against iron toxicity are attributed to the anti-oxidative properties by activating Akt/Nrf2 pathway and increasing Nrf2-induced expression of HO-1 and Cu/Zn SOD.	Iron	70-74	NFE2 like bZIP transcription factor 2	Homo sapiens	178-182
23946774-7	2013	Even at low doses of radiation from iron ions, global genome profiling of the irradiated cells revealed the upregulation of genes associated with the activation of stress-related signaling pathways (ubiquitin-mediated proteolysis, p53 signaling, cell cycle and apoptosis), which occurred in a dose-dependent manner.	Iron	36-40	tumor protein p53	Homo sapiens	231-234
23199217-5	2013	Recent advances in understanding the reduction and uptake of non-transferrin-bound iron are discussed.	Iron	83-87	transferrin	Homo sapiens	65-76
23524988-4	2013	The pathophysiology of RLS is centred on dopaminergic dysfunction, reduced central nervous system iron, genetic linkages, or alteration in neurotransmitters such as hypocretins, endorphins levels and immune dysfunction and inflammatory mechanisms.	Iron	98-102	RLS1	Homo sapiens	23-26
24024382-7	2013	CONCLUSION: The nutritional status of the iron may be affected by copper deficiency through influencing the absorption, the results indicate that copper deficiency influences iron homeostasis in cells through affecting the expression of IRP2 and the activity of IRP-RNA combination which change the expressions of ferritin and transferrin mRNA.	Iron	42-46	transferrin	Rattus norvegicus	327-338
23707944-11	2013	Moreover, a key regulator of iron homeostasis, hepcidin gene expression was increased in the failing right ventricle of monocrotaline-injected rats.	Iron	29-33	hepcidin antimicrobial peptide	Rattus norvegicus	47-55
23709747-10	2013	These results suggest that hypoxia dysregulates the expressions of LDHA, FASN, and mACON genes, and the hypoxia-induced mACON gene expression is via the HIF-1alpha-dependent and iron-dependent pathways in prostate carcinoma cells.	Iron	178-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-163
23826084-1	2013	We report the discovery of a novel dual inhibitor targeting fungal sterol 14alpha-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core.	Iron	208-212	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	67-93
23826084-1	2013	We report the discovery of a novel dual inhibitor targeting fungal sterol 14alpha-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core.	Iron	208-212	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	95-100
23826084-1	2013	We report the discovery of a novel dual inhibitor targeting fungal sterol 14alpha-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core.	Iron	208-212	arachidonate 5-lipoxygenase	Homo sapiens	121-135
23826084-1	2013	We report the discovery of a novel dual inhibitor targeting fungal sterol 14alpha-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core.	Iron	208-212	arachidonate 5-lipoxygenase	Homo sapiens	137-142
23805238-6	2013	Moreover, ferroportin (FPN-1), the main protein involved in iron export, was down-regulated accordingly with hepcidin increase.	Iron	60-64	solute carrier family 40 member 1	Rattus norvegicus	23-28
23805238-6	2013	Moreover, ferroportin (FPN-1), the main protein involved in iron export, was down-regulated accordingly with hepcidin increase.	Iron	60-64	hepcidin antimicrobial peptide	Rattus norvegicus	109-117
23611804-1	2013	This study confirmed the feasibility of natural limonite working as the iron catalyst for the PNP wastewater treatment in the BES-Fenton system.	Iron	72-76	purine nucleoside phosphorylase	Homo sapiens	94-97
23684642-0	2013	Helicobacter pylori secretes the chaperonin GroEL (HSP60), which binds iron.	Iron	71-75	GroEL	Escherichia coli	44-49
23662623-2	2013	One possible secondary reaction is the involvement of NO3(-) and nitrite (NO2(-)) with magnetite, a mixed valence Fe(2+)/Fe(3+) mineral found in many natural environments.	Iron	114-116	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
23662623-2	2013	One possible secondary reaction is the involvement of NO3(-) and nitrite (NO2(-)) with magnetite, a mixed valence Fe(2+)/Fe(3+) mineral found in many natural environments.	Iron	121-123	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
23662623-4	2013	This study investigates NO3(-) and NO2(-) reactivity with magnetite under anoxic conditions using batch kinetic experiments across a range of pH values (5.5-7.5) and in the presence of added dissolved Fe(2+).	Iron	201-203	NBL1, DAN family BMP antagonist	Homo sapiens	24-27
23611804-6	2013	This study suggests an efficiency and cost-effective approach for the PNP removal by using the natural limonite as the iron catalyst of the BES-Fenton system.	Iron	119-123	purine nucleoside phosphorylase	Homo sapiens	70-73
23640898-0	2013	Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin.	Iron	70-74	poly(rC) binding protein 1	Homo sapiens	19-46
23640898-0	2013	Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin.	Iron	70-74	poly(rC) binding protein 1	Homo sapiens	48-52
23640898-2	2013	Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1.	Iron	42-46	poly(rC) binding protein 1	Homo sapiens	0-27
23640898-2	2013	Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1.	Iron	42-46	poly(rC) binding protein 1	Homo sapiens	29-34
23640898-2	2013	Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1.	Iron	121-125	poly(rC) binding protein 1	Homo sapiens	0-27
23640898-2	2013	Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1.	Iron	121-125	poly(rC) binding protein 1	Homo sapiens	29-34
23640898-2	2013	Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1.	Iron	121-125	poly(rC) binding protein 1	Homo sapiens	76-81
23640898-2	2013	Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1.	Iron	121-125	poly(rC) binding protein 2	Homo sapiens	98-103
23640898-2	2013	Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1.	Iron	121-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	176-180
23640898-3	2013	Here we show that PCBP2 is also an iron chaperone for ferritin.	Iron	35-39	poly(rC) binding protein 2	Homo sapiens	18-23
23640898-4	2013	Co-expression of PCBP2 and human ferritins in yeast activated the iron deficiency response and increased iron deposition into ferritin.	Iron	66-70	poly(rC) binding protein 2	Homo sapiens	17-22
23640898-5	2013	Depletion of PCBP2 in Huh7 cells diminished iron incorporation into ferritin.	Iron	44-48	poly(rC) binding protein 2	Homo sapiens	13-18
23640898-10	2013	Expression of PCBP1 and ferritin in an iron-sensitive, ccc1 yeast strain intensified the toxic effects of iron, whereas expression of PCBP4 protected the cells from iron toxicity.	Iron	39-43	poly(rC) binding protein 1	Homo sapiens	14-19
23640898-10	2013	Expression of PCBP1 and ferritin in an iron-sensitive, ccc1 yeast strain intensified the toxic effects of iron, whereas expression of PCBP4 protected the cells from iron toxicity.	Iron	106-110	poly(rC) binding protein 1	Homo sapiens	14-19
23640898-10	2013	Expression of PCBP1 and ferritin in an iron-sensitive, ccc1 yeast strain intensified the toxic effects of iron, whereas expression of PCBP4 protected the cells from iron toxicity.	Iron	106-110	poly(rC) binding protein 1	Homo sapiens	14-19
23640898-11	2013	Thus, PCBP1 and -2 form a complex for iron delivery to ferritin, and all PCBPs may share iron chaperone activity.	Iron	38-42	poly(rC) binding protein 1	Homo sapiens	6-18
23716661-0	2013	Pirin is an iron-dependent redox regulator of NF-kappaB.	Iron	12-16	pirin	Homo sapiens	0-5
23716661-0	2013	Pirin is an iron-dependent redox regulator of NF-kappaB.	Iron	12-16	nuclear factor kappa B subunit 1	Homo sapiens	46-55
23758715-12	2013	Conversely, levels of iron status indicators (ferritin, transferrin saturation and iron) were higher in cord serum (p &lt; 0.05).	Iron	22-26	transferrin	Homo sapiens	56-67
22702311-0	2013	Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine beta145.	Iron	49-53	haptoglobin	Homo sapiens	0-11
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	215-219	cytochrome b reductase 1	Mus musculus	256-261
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	215-219	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	263-267
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	20-24	cytochrome b reductase 1	Mus musculus	256-261
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	20-24	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	263-267
23589083-3	2013	An experimentally elusive common intermediate [Fe(CO)2NO(Ac)] has been identified in two isomers and reacted in silico with a number of ligands (CO, PH3 and PPh3) to give the corresponding iron acyl complexes.	Iron	189-193	caveolin 1	Homo sapiens	157-161
23754812-6	2013	In addition, we were able to complement a yeast mutant in the cytosolic Fe-S cluster assembly pathway, dre2, with the Arabidopsis homologue AtDRE2, but only when expressed together with the diflavin reductase AtTAH18.	Iron	72-76	Flavodoxin family protein	Arabidopsis thaliana	209-216
23492967-12	2013	Computer modeling studies predicted that etomidate, carboetomidate, and azi-etomidate can fit into the heme-containing pocket that forms 11beta-hydroxylase"s active site and pose with their carbonyl oxygens interacting with the heme iron and their phenyl rings stacking with phenylalanine-80.	Iron	233-237	antizyme inhibitor 1	Homo sapiens	72-75
23578384-5	2013	Decreased insulin signaling, evaluated by the phospho-Akt/Akt ratio, was detected in the visceral adipose tissue of iron overloaded mice, and gene expression analysis of visceral adipose tissue showed that an iron-enriched diet up-regulated iron-responsive genes and adipokines, favoring insulin resistance, whereas lipoprotein lipase was down-regulated.	Iron	116-120	thymoma viral proto-oncogene 1	Mus musculus	54-57
23578384-5	2013	Decreased insulin signaling, evaluated by the phospho-Akt/Akt ratio, was detected in the visceral adipose tissue of iron overloaded mice, and gene expression analysis of visceral adipose tissue showed that an iron-enriched diet up-regulated iron-responsive genes and adipokines, favoring insulin resistance, whereas lipoprotein lipase was down-regulated.	Iron	116-120	thymoma viral proto-oncogene 1	Mus musculus	58-61
23578384-5	2013	Decreased insulin signaling, evaluated by the phospho-Akt/Akt ratio, was detected in the visceral adipose tissue of iron overloaded mice, and gene expression analysis of visceral adipose tissue showed that an iron-enriched diet up-regulated iron-responsive genes and adipokines, favoring insulin resistance, whereas lipoprotein lipase was down-regulated.	Iron	209-213	thymoma viral proto-oncogene 1	Mus musculus	54-57
23578384-5	2013	Decreased insulin signaling, evaluated by the phospho-Akt/Akt ratio, was detected in the visceral adipose tissue of iron overloaded mice, and gene expression analysis of visceral adipose tissue showed that an iron-enriched diet up-regulated iron-responsive genes and adipokines, favoring insulin resistance, whereas lipoprotein lipase was down-regulated.	Iron	209-213	thymoma viral proto-oncogene 1	Mus musculus	58-61
23578384-5	2013	Decreased insulin signaling, evaluated by the phospho-Akt/Akt ratio, was detected in the visceral adipose tissue of iron overloaded mice, and gene expression analysis of visceral adipose tissue showed that an iron-enriched diet up-regulated iron-responsive genes and adipokines, favoring insulin resistance, whereas lipoprotein lipase was down-regulated.	Iron	209-213	thymoma viral proto-oncogene 1	Mus musculus	54-57
23578384-5	2013	Decreased insulin signaling, evaluated by the phospho-Akt/Akt ratio, was detected in the visceral adipose tissue of iron overloaded mice, and gene expression analysis of visceral adipose tissue showed that an iron-enriched diet up-regulated iron-responsive genes and adipokines, favoring insulin resistance, whereas lipoprotein lipase was down-regulated.	Iron	209-213	thymoma viral proto-oncogene 1	Mus musculus	58-61
23518448-2	2013	ACO2 was selected for this study because (1) it is known to be inactivated by HNE, (2) elevated concentrations of HNE-adducted ACO2 have been associated with disease states, (3) extensive structural information is available, and (4) the iron-sulfur cluster in ACO2 offers a critical target for HNE adduction.	Iron	237-241	aconitase 2	Homo sapiens	0-4
23481043-2	2013	Transferrin is a serum Fe transport protein supplying almost all cellular Fe under physiological conditions.	Iron	23-25	transferrin	Homo sapiens	0-11
23481043-2	2013	Transferrin is a serum Fe transport protein supplying almost all cellular Fe under physiological conditions.	Iron	74-76	transferrin	Homo sapiens	0-11
23481043-4	2013	At typical plasma concentrations, ascorbate significantly increased (59)Fe uptake from transferrin by 1.5-2-fold in a range of cells.	Iron	72-74	transferrin	Homo sapiens	87-98
23481043-13	2013	Therefore, ascorbate is a novel modulator of the classical transferrin Fe uptake pathway, acting via an intracellular reductive mechanism.	Iron	71-73	transferrin	Homo sapiens	59-70
23481043-0	2013	Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism.	Iron	12-16	transferrin	Homo sapiens	0-11
23518448-2	2013	ACO2 was selected for this study because (1) it is known to be inactivated by HNE, (2) elevated concentrations of HNE-adducted ACO2 have been associated with disease states, (3) extensive structural information is available, and (4) the iron-sulfur cluster in ACO2 offers a critical target for HNE adduction.	Iron	237-241	aconitase 2	Homo sapiens	127-131
23541988-0	2013	Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition.	Iron	114-118	transferrin	Homo sapiens	80-91
23541988-1	2013	BACKGROUND: The long held view is that mammalian cells obtain transferrin (Tf) bound iron utilizing specialized membrane anchored receptors.	Iron	85-89	transferrin	Homo sapiens	62-73
23518448-2	2013	ACO2 was selected for this study because (1) it is known to be inactivated by HNE, (2) elevated concentrations of HNE-adducted ACO2 have been associated with disease states, (3) extensive structural information is available, and (4) the iron-sulfur cluster in ACO2 offers a critical target for HNE adduction.	Iron	237-241	aconitase 2	Homo sapiens	127-131
23541988-2	2013	Here we report that, during increased iron demand, cells secrete the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) which enhances cellular uptake of Tf and iron.	Iron	38-42	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	129-134
23541988-2	2013	Here we report that, during increased iron demand, cells secrete the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) which enhances cellular uptake of Tf and iron.	Iron	177-181	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	129-134
23605050-3	2013	The purpose of this study was to describe the effect of different iron and/or glucose concentrations over Mfn2, Bax, and Bcl2 expressions in a beta-pancreatic cell line (MIN6 cells).	Iron	66-70	B cell leukemia/lymphoma 2	Mus musculus	121-125
23541988-7	2013	CONCLUSIONS: Our research demonstrates that, even in cell types that express the known surface receptor based mechanism for transferrin uptake, more transferrin is delivered by this route which represents a hidden dimension of iron homeostasis.	Iron	227-231	transferrin	Homo sapiens	124-135
23541988-7	2013	CONCLUSIONS: Our research demonstrates that, even in cell types that express the known surface receptor based mechanism for transferrin uptake, more transferrin is delivered by this route which represents a hidden dimension of iron homeostasis.	Iron	227-231	transferrin	Homo sapiens	149-160
23605050-9	2013	Our study revealed that high glucose/Fe concentrations in MIN6 cells induced an increase of the Bcl2/Bax ratio, an indicator of increased cell apoptosis.	Iron	37-39	B cell leukemia/lymphoma 2	Mus musculus	96-100
23737117-2	2013	In these patients, prompt application of iron therapy can help to reduce the dependence of erythropoietin-stimulating agents and effectively treat anemia.	Iron	41-45	erythropoietin	Homo sapiens	91-105
23964391-0	2013	Differences in circulating non-transferrin-bound iron after oral administration of ferrous sulfate, sodium iron EDTA, or iron polymaltose in women with marginal iron stores.	Iron	49-53	transferrin	Homo sapiens	31-42
23964391-2	2013	OBJECTIVE: To determine the responses of circulating non-transferrin-bound iron (NTBI) and plasma iron to three different oral iron compounds--ferrous sulfate, sodium iron ethylenediaminetetraacetate (NaFeEDTA), and iron polymaltose (IPM)--in women with marginal iron stores.	Iron	75-79	transferrin	Homo sapiens	57-68
23687123-3	2013	The aim of this study was to define the phenotype that is associated with mutations in WDR45, a new causative gene for neurodegeneration with brain iron accumulation located on the X chromosome.	Iron	148-152	WD repeat domain 45	Homo sapiens	87-92
23687123-4	2013	The study subjects consisted of WDR45 mutation-positive individuals identified after screening a large international cohort of patients with idiopathic neurodegeneration with brain iron accumulation.	Iron	181-185	WD repeat domain 45	Homo sapiens	32-37
23390091-0	2013	Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.	Iron	45-49	proprotein convertase subtilisin/kexin type 7	Homo sapiens	63-86
23390091-10	2013	Finally, depletion of iron in the medium of hepatoma cell lines incubated with the iron chelator desferrioxamine resulted in PC7 down-regulation.	Iron	22-26	proprotein convertase subtilisin/kexin type 7	Homo sapiens	125-128
23390091-10	2013	Finally, depletion of iron in the medium of hepatoma cell lines incubated with the iron chelator desferrioxamine resulted in PC7 down-regulation.	Iron	83-87	proprotein convertase subtilisin/kexin type 7	Homo sapiens	125-128
23390091-12	2013	Our results support the notion that, when iron is limiting, hTfR1 levels increase at least in part by way of the down-regulation of PC7 expression.	Iron	42-46	proprotein convertase subtilisin/kexin type 7	Homo sapiens	132-135
23631927-3	2013	Iron deficient pregnant dams and their pups displayed elevated corticosterone which, in turn, differentially affected glucocorticoid receptor (GR) expression in the CA1 and the dentate gyrus.	Iron	0-4	nuclear receptor subfamily 3 group C member 1	Homo sapiens	118-141
23631927-3	2013	Iron deficient pregnant dams and their pups displayed elevated corticosterone which, in turn, differentially affected glucocorticoid receptor (GR) expression in the CA1 and the dentate gyrus.	Iron	0-4	nuclear receptor subfamily 3 group C member 1	Homo sapiens	143-145
23454680-3	2013	Here, we report that down-regulation of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) may contribute to iron-induced alpha-syn aggregation.	Iron	128-132	NFE2 like bZIP transcription factor 2	Homo sapiens	40-74
23454680-8	2013	These results support a new hypothesis of synergistic alpha-syn/iron cytotoxicity, whereby ferrous iron induces alpha-syn aggregation and neurotoxicity by inhibiting Nrf2/HO-1.	Iron	64-68	NFE2 like bZIP transcription factor 2	Homo sapiens	166-170
23454680-9	2013	Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD.	Iron	92-96	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
23454680-3	2013	Here, we report that down-regulation of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) may contribute to iron-induced alpha-syn aggregation.	Iron	128-132	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
23454680-9	2013	Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD.	Iron	126-130	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
23463547-4	2013	The present results showed that both CYP2A13 and POR were presented the highest expression levels or activity with 0.2 mM delta-aminolaevulinic acid (5-ALA), 0.02 mM Fe(3+) and 0.5-1.0 mug/ml hemin.	Iron	166-168	cytochrome p450 oxidoreductase	Homo sapiens	49-52
23811551-7	2013	We found a significant positive correlation between IL-4 and total iron binding capacity (TIBC, p=0.046) and between serum IL-10 and Hb levels (p=0.041) in the RVVC+ IDA- group.	Iron	67-71	interleukin 4	Homo sapiens	52-56
23811551-8	2013	There was also a significant negative correlation between serum IL-4 and levels of serum iron (SI, p=0.041) in the RVVC- IDA- group.	Iron	89-93	interleukin 4	Homo sapiens	64-68
23704825-12	2013	CONCLUSION: Reducing hepatic iron deposition and CO levels by inhibiting HO-1 activity though the Nrf2/Keap pathway could be helpful in improving hepatic fibrosis and regulating PVP.	Iron	29-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	98-102
23552122-13	2013	Moreover, iron restriction markedly attenuated renal expression of nuclear mineralocorticoid receptor and Rac1 activity in CKD rats.	Iron	10-14	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	75-101
23552122-15	2013	The beneficial effects of iron restriction on renal damage seem to be associated with inhibition of renal mineralocorticoid receptor signaling.	Iron	26-30	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	106-132
23598994-2	2013	Deleting the mitochondrial carrier gene MTM1 causes Fe to accumulate in mitochondria and Mn superoxide dismutase (SOD2) activity to decline.	Iron	52-54	Mtm1p	Saccharomyces cerevisiae S288C	40-44
23476046-8	2013	NOS3 methylation was negatively associated with PM10 (beta=-0.2, 95% CI -0.4 to -0.03), PM1 (beta=-0.8, 95% CI -1.4 to -0.1), zinc (beta=-0.9, 95% CI -1.4 to -0.3) and iron (beta=-0.7, 95% CI -1.4 to -0.01) exposures.	Iron	168-172	nitric oxide synthase 3	Homo sapiens	0-4
23729726-1	2013	Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	95-102
23729726-1	2013	Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	117-129
23729726-1	2013	Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2.	Iron	16-20	transmembrane serine protease 6	Homo sapiens	95-102
23729726-1	2013	Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2.	Iron	16-20	transmembrane serine protease 6	Homo sapiens	117-129
23524846-1	2013	Ferritin L (FTL) and ferritin H (FTH) subunits are responsible for intracellular iron storage.	Iron	81-85	ferritin light chain 1	Rattus norvegicus	0-10
23524846-1	2013	Ferritin L (FTL) and ferritin H (FTH) subunits are responsible for intracellular iron storage.	Iron	81-85	ferritin light chain 1	Rattus norvegicus	12-15
23524846-1	2013	Ferritin L (FTL) and ferritin H (FTH) subunits are responsible for intracellular iron storage.	Iron	81-85	ferritin heavy chain 1	Rattus norvegicus	21-31
23524846-1	2013	Ferritin L (FTL) and ferritin H (FTH) subunits are responsible for intracellular iron storage.	Iron	81-85	ferritin heavy chain 1	Rattus norvegicus	33-36
23645578-0	2013	The relationship between depressive symptoms and erythropoietin resistance in stable hemodialysis patients with adequate iron stores.	Iron	121-125	erythropoietin	Homo sapiens	49-63
23600523-1	2013	Reaction of [fc(NH2)2]RuCl2(PPh3)2 (fc = 1,1"-ferrocenylene) with 2 equiv of KO(t)Bu led to the formation of a diamido ruthenium complex, [fc(NH)2]Ru(PPh3)2, whose solid-state molecular structure revealed a short Fe-Ru distance.	Iron	213-215	caveolin 1	Homo sapiens	28-32
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	interleukin 1 beta	Mus musculus	24-32
23508953-0	2013	Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism.	Iron	116-120	iron-sulfur cluster assembly enzyme	Homo sapiens	85-89
23508953-1	2013	The scaffold protein ISCU facilitates the assembly of iron-sulfur clusters (ISCs), which are essential cofactors for many vital metabolic processes.	Iron	54-58	iron-sulfur cluster assembly enzyme	Homo sapiens	21-25
23508953-6	2013	Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply.	Iron	79-83	iron-sulfur cluster assembly enzyme	Homo sapiens	10-14
23508953-6	2013	Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply.	Iron	141-145	iron-sulfur cluster assembly enzyme	Homo sapiens	10-14
23376588-3	2013	In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons.	Iron	203-207	interleukin 1 beta	Mus musculus	85-102
23376588-3	2013	In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons.	Iron	203-207	interleukin 1 beta	Mus musculus	104-112
23630227-0	2013	Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection.	Iron	70-74	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	36-49
23630227-1	2013	Nitric oxide (NO) generated by inducible NO synthase 2 (NOS2) affects cellular iron homeostasis, but the underlying molecular mechanisms and implications for NOS2-dependent pathogen control are incompletely understood.	Iron	79-83	nitric oxide synthase 2, inducible	Mus musculus	56-60
23630227-2	2013	In this study, we found that NO up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells.	Iron	104-108	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	63-76
23630227-2	2013	In this study, we found that NO up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells.	Iron	104-108	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	78-82
23630227-3	2013	Nos2(-/-) macrophages displayed increased iron content due to reduced Fpn1 expression and allowed for an enhanced iron acquisition by the intracellular bacterium Salmonella typhimurium.	Iron	42-46	nitric oxide synthase 2, inducible	Mus musculus	0-4
23630227-3	2013	Nos2(-/-) macrophages displayed increased iron content due to reduced Fpn1 expression and allowed for an enhanced iron acquisition by the intracellular bacterium Salmonella typhimurium.	Iron	114-118	nitric oxide synthase 2, inducible	Mus musculus	0-4
23630227-4	2013	Nos2 gene disruption or inhibition of NOS2 activity led to an accumulation of iron in the spleen and splenic macrophages.	Iron	78-82	nitric oxide synthase 2, inducible	Mus musculus	0-4
23630227-4	2013	Nos2 gene disruption or inhibition of NOS2 activity led to an accumulation of iron in the spleen and splenic macrophages.	Iron	78-82	nitric oxide synthase 2, inducible	Mus musculus	38-42
23630227-6	2013	After infection of Nos2(-/-) macrophages or mice with S. typhimurium, the increased iron accumulation was paralleled by a reduced cytokine (TNF, IL-12, and IFN-gamma) expression and impaired pathogen control, all of which were restored upon administration of the iron chelator deferasirox or hyperexpression of Fpn1 or Nrf2.	Iron	84-88	nitric oxide synthase 2, inducible	Mus musculus	19-23
23630227-6	2013	After infection of Nos2(-/-) macrophages or mice with S. typhimurium, the increased iron accumulation was paralleled by a reduced cytokine (TNF, IL-12, and IFN-gamma) expression and impaired pathogen control, all of which were restored upon administration of the iron chelator deferasirox or hyperexpression of Fpn1 or Nrf2.	Iron	84-88	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	311-315
23630227-6	2013	After infection of Nos2(-/-) macrophages or mice with S. typhimurium, the increased iron accumulation was paralleled by a reduced cytokine (TNF, IL-12, and IFN-gamma) expression and impaired pathogen control, all of which were restored upon administration of the iron chelator deferasirox or hyperexpression of Fpn1 or Nrf2.	Iron	263-267	nitric oxide synthase 2, inducible	Mus musculus	19-23
23630227-7	2013	Thus, the accumulation of iron in Nos2(-/-) macrophages counteracts a proinflammatory host immune response, and the protective effect of NO appears to partially result from its ability to prevent iron overload in macrophages.	Iron	26-30	nitric oxide synthase 2, inducible	Mus musculus	34-38
23376588-3	2013	In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons.	Iron	203-207	tumor necrosis factor	Mus musculus	118-145
23376588-3	2013	In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons.	Iron	203-207	tumor necrosis factor	Mus musculus	147-156
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	81-85	interleukin 1 beta	Mus musculus	24-32
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	81-85	tumor necrosis factor	Mus musculus	36-45
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	interleukin 1 beta	Mus musculus	24-32
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	tumor necrosis factor	Mus musculus	36-45
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	tumor necrosis factor	Mus musculus	36-45
23376588-7	2013	Further experiments demonstrated that IL-1beta and TNF-alpha release was remarkably enhanced by iron load in activated microglia triggered by lipopolysaccharide or 1-methyl-4-phenylpyridinium (MPP(+)).	Iron	96-100	interleukin 1 beta	Mus musculus	38-46
23376588-7	2013	Further experiments demonstrated that IL-1beta and TNF-alpha release was remarkably enhanced by iron load in activated microglia triggered by lipopolysaccharide or 1-methyl-4-phenylpyridinium (MPP(+)).	Iron	96-100	tumor necrosis factor	Mus musculus	51-60
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	109-113	interleukin 1 beta	Mus musculus	29-37
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	109-113	tumor necrosis factor	Mus musculus	42-51
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	140-144	interleukin 1 beta	Mus musculus	29-37
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	140-144	tumor necrosis factor	Mus musculus	42-51
23483119-4	2013	In the present study, we show that, in addition to these well-studied molecular mechanisms, the treatment of wild-type TP53 MCF-7 and mutant TP53 MDA-MB-231 human breast cancer cells with desferrioxamine (DFO), a model iron chelator, causes significant epigenetic alterations at the global and gene-specific levels.	Iron	219-223	tumor protein p53	Homo sapiens	119-123
23656253-2	2013	Our aim was to understand the functional axis response composed of erythropoietin (Epo)-hepcidin-ferroportin (FPN), when 2 dysfunctional states coexist, using an animal model of iron overload followed by hypoxia.	Iron	178-182	erythropoietin	Homo sapiens	67-81
23656253-2	2013	Our aim was to understand the functional axis response composed of erythropoietin (Epo)-hepcidin-ferroportin (FPN), when 2 dysfunctional states coexist, using an animal model of iron overload followed by hypoxia.	Iron	178-182	erythropoietin	Homo sapiens	83-86
23656253-11	2013	Our data indicate that 2 signals could induce the cell-specific response as follows: (i) iron signal, induced prohepcidin, which reduced reticuloendothelial FPN and reduced iron availability; and (ii) hypoxia signal, stimulated Epo, which affected iron absorption by stabilizing duodenal FPN and allowed iron supply to erythropoiesis independently of store size.	Iron	89-93	erythropoietin	Homo sapiens	228-231
23656253-11	2013	Our data indicate that 2 signals could induce the cell-specific response as follows: (i) iron signal, induced prohepcidin, which reduced reticuloendothelial FPN and reduced iron availability; and (ii) hypoxia signal, stimulated Epo, which affected iron absorption by stabilizing duodenal FPN and allowed iron supply to erythropoiesis independently of store size.	Iron	173-177	erythropoietin	Homo sapiens	228-231
23656253-11	2013	Our data indicate that 2 signals could induce the cell-specific response as follows: (i) iron signal, induced prohepcidin, which reduced reticuloendothelial FPN and reduced iron availability; and (ii) hypoxia signal, stimulated Epo, which affected iron absorption by stabilizing duodenal FPN and allowed iron supply to erythropoiesis independently of store size.	Iron	173-177	erythropoietin	Homo sapiens	228-231
23656253-11	2013	Our data indicate that 2 signals could induce the cell-specific response as follows: (i) iron signal, induced prohepcidin, which reduced reticuloendothelial FPN and reduced iron availability; and (ii) hypoxia signal, stimulated Epo, which affected iron absorption by stabilizing duodenal FPN and allowed iron supply to erythropoiesis independently of store size.	Iron	173-177	erythropoietin	Homo sapiens	228-231
23416122-5	2013	Children with Hp 2-2 phenotype showed significantly higher iron storage compared to those with Hp 1-1 and Hp 2-1 phenotypes when children with malaria parasites and high C-reactive protein (&gt;9mg/L) were excluded from the analysis.	Iron	59-63	C-reactive protein	Homo sapiens	170-188
23404373-4	2013	We describe an approach combining heme iron oxidation with potassium ferricyanide and metabolite profiling to probe the mechanism of MI complex-based CYP3A4 inactivation by the secondary alkylamine drug lapatinib.	Iron	39-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	150-156
23586878-0	2013	Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals.	Iron	91-95	transferrin	Homo sapiens	73-84
23586878-2	2013	Transferrin (Tf) is responsible for iron transport and its interactions with chelators are of physiological and toxicological importance and could lead to new therapeutic applications.	Iron	36-40	transferrin	Homo sapiens	0-11
23586878-2	2013	Transferrin (Tf) is responsible for iron transport and its interactions with chelators are of physiological and toxicological importance and could lead to new therapeutic applications.	Iron	36-40	transferrin	Homo sapiens	13-15
23586878-3	2013	AREAS COVERED: Differential interactions of Tf with chelators such as deferiprone (L1) could be used to modify toxicity and disease pathways in relation to iron and other metal metabolism.	Iron	156-160	transferrin	Homo sapiens	44-46
23586878-5	2013	Iron mobilization from the reticuloendothelial system by L1 and exchange with Tf could be used to increase the production of hemoglobin in the anemia of chronic disease.	Iron	0-4	transferrin	Homo sapiens	78-80
23483119-4	2013	In the present study, we show that, in addition to these well-studied molecular mechanisms, the treatment of wild-type TP53 MCF-7 and mutant TP53 MDA-MB-231 human breast cancer cells with desferrioxamine (DFO), a model iron chelator, causes significant epigenetic alterations at the global and gene-specific levels.	Iron	219-223	tumor protein p53	Homo sapiens	141-145
23471031-8	2013	HH patients had significantly lower serum PON1 activity, which was inversely correlated with ferritin (marker of iron stores) and serum 8-isoprostane concentrations (index of oxidative stress).	Iron	113-117	paraoxonase 1	Homo sapiens	42-46
24218836-0	2013	Pb(II) removal from water using Fe-coated bamboo charcoal with the assistance of microwaves.	Iron	32-34	submaxillary gland androgen regulated protein 3B	Homo sapiens	0-6
23471031-10	2013	Our study provides preliminary evidence that PON1 may play a role in protecting against iron-induced oxidative stress in hereditary hemochromatosis.	Iron	88-92	paraoxonase 1	Homo sapiens	45-49
23519153-7	2013	In addition to copper-related changes, compensatory upregulations of Cp and Hamp reflect iron-mediated neurotoxicity.	Iron	89-93	hepcidin antimicrobial peptide	Rattus norvegicus	76-80
23536430-4	2013	Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/beta-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm.	Iron	162-166	charged multivesicular body protein 2B	Homo sapiens	133-137
23536430-4	2013	Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/beta-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm.	Iron	171-175	charged multivesicular body protein 2B	Homo sapiens	133-137
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	39-43	transferrin	Rattus norvegicus	121-132
23848110-4	2013	RESULTS: The main results were: (a) women had lower intake of most micronutrients than men (b) pantothenic acid, vitamin B12 and E, calcium, magnesium and iron are nutrients that showed mean intakes below the daily recommendations, (c) the consumption of bread is essential for the supply of B vitamins, iron, copper and selenium.	Iron	155-159	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	121-124
23486660-2	2013	Erythropoietin therapy, however, allowed for the first time, such patients to achieve a sustained correction of anaemia, and there was a dramatic fall in both the use of red cell transfusions in dialysis units, as well as the associated transfusional iron overload prevalent in dialysis patients.	Iron	251-255	erythropoietin	Homo sapiens	0-14
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	39-43	hepcidin antimicrobial peptide	Rattus norvegicus	172-180
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	75-79	transferrin	Rattus norvegicus	121-132
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	75-79	hepcidin antimicrobial peptide	Rattus norvegicus	172-180
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	75-79	transferrin	Rattus norvegicus	121-132
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	75-79	hepcidin antimicrobial peptide	Rattus norvegicus	172-180
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	75-79	transferrin	Rattus norvegicus	121-132
23635304-7	2013	RESULTS: A reduction in maternal liver iron content in response to the low iron diet was associated with upregulation of transferrin receptor expression and a reduction in hepcidin expression in the liver of both strains, which would be expected to promote increased iron absorption across the gut and increased turnover of iron in the liver.	Iron	75-79	hepcidin antimicrobial peptide	Rattus norvegicus	172-180
23635304-8	2013	Placental expression of transferrin and DMT1+IRE were also upregulated, indicating adaptive responses to ensure availability of iron to the fetus.	Iron	128-132	transferrin	Rattus norvegicus	24-35
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	56-60	caspase 3	Homo sapiens	186-195
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	56-60	BCL2 apoptosis regulator	Homo sapiens	200-205
23688756-7	2013	The expressions of Bcl-2 on BMMNC, erythrocytes and stem cells of iron overloading IRP patients were significantly lower than those of non-iron overloading IRP ones (P &lt; 0.05).	Iron	66-70	BCL2 apoptosis regulator	Homo sapiens	19-24
23688756-7	2013	The expressions of Bcl-2 on BMMNC, erythrocytes and stem cells of iron overloading IRP patients were significantly lower than those of non-iron overloading IRP ones (P &lt; 0.05).	Iron	139-143	BCL2 apoptosis regulator	Homo sapiens	19-24
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	142-146	caspase 3	Homo sapiens	186-195
23688756-8	2013	The levels of Caspase-3 on myelocytes, erythrocytes and stem cells of iron overloading IRP patients were significantly higher than those of non-iron overloading IRP ones and normal controls (P &lt; 0.05).	Iron	70-74	caspase 3	Homo sapiens	14-23
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	142-146	BCL2 apoptosis regulator	Homo sapiens	200-205
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	142-146	caspase 3	Homo sapiens	186-195
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	142-146	BCL2 apoptosis regulator	Homo sapiens	200-205
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	366-370	caspase 3	Homo sapiens	186-195
23601103-7	2013	Loss of the C. elegans hypoxia-inducing factor HIF-1, which regulates iron homeostasis, exacerbated P. aeruginosa pathogenesis, further linking hypoxia and killing.	Iron	70-74	Hypoxia-inducible factor 1	Caenorhabditis elegans	47-52
23457300-0	2013	Loss of vacuolar H+-ATPase (V-ATPase) activity in yeast generates an iron deprivation signal that is moderated by induction of the peroxiredoxin TSA2.	Iron	69-73	thioredoxin peroxidase TSA2	Saccharomyces cerevisiae S288C	145-149
23457300-12	2013	Iron supplementation significantly decreased P(FIT2)-GFP expression and, surprisingly, restored P(TSA2)-GFP to wild-type levels.	Iron	0-4	thioredoxin peroxidase TSA2	Saccharomyces cerevisiae S288C	98-102
23596212-2	2013	In the cytosolic iron-sulfur protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-sulfur cluster proteins.	Iron	17-21	cytokine induced apoptosis inhibitor 1	Homo sapiens	135-144
23596212-2	2013	In the cytosolic iron-sulfur protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-sulfur cluster proteins.	Iron	240-244	cytokine induced apoptosis inhibitor 1	Homo sapiens	135-144
23634216-5	2013	The reduction of camphor and simultaneous oxidation of water are likely catalyzed by the iron-oxo intermediate of P450(cam) , and we present a plausible mechanism that accounts for the 1:1 borneol:H2O2 stoichiometry we observed.	Iron	89-93	calmodulin 3	Homo sapiens	114-123
23363555-7	2013	We also show that NO leads to the inhibition of iron uptake via the Tf (transferrin)-Tf receptor pathway.	Iron	48-52	transferrin	Homo sapiens	72-83
23454461-1	2013	In this study, the US-ZVI system was used to produce the strong reductants including H and nascent Fe(2+) ions to eliminate the toxicity of the high concentration p-nitrophenol (PNP) wastewater.	Iron	22-25	purine nucleoside phosphorylase	Homo sapiens	178-181
23454461-4	2013	Furthermore, the removal efficiencies of PNP increased obviously with the increase of initial ZVI concentration from 0 to 15 gL(-1).	Iron	94-97	purine nucleoside phosphorylase	Homo sapiens	41-44
23454461-5	2013	Also, the treatment capacity of ZVI was enhanced remarkably by the ultrasonic irradiation, and the US-ZVI system can maintain high treatment efficiency for the high concentration PNP wastewater (500-10,000 mgL(-1)).	Iron	32-35	purine nucleoside phosphorylase	Homo sapiens	179-182
23454461-5	2013	Also, the treatment capacity of ZVI was enhanced remarkably by the ultrasonic irradiation, and the US-ZVI system can maintain high treatment efficiency for the high concentration PNP wastewater (500-10,000 mgL(-1)).	Iron	102-105	purine nucleoside phosphorylase	Homo sapiens	179-182
23454461-6	2013	Meanwhile, the high removal efficiency of PNP was mainly resulted from the synergistic reaction of ZVI and US.	Iron	99-102	purine nucleoside phosphorylase	Homo sapiens	42-45
23454461-8	2013	Thus, the reaction pathway of PNP in the US-ZVI system is proposed as a reducing process by the H and nascent Fe(2+) ions.	Iron	44-47	purine nucleoside phosphorylase	Homo sapiens	30-33
23578325-6	2013	Thrombin is also added to whole blood exposed to iron, glucose and blood from diabetes and hemochromatosis patients.	Iron	49-53	coagulation factor II, thrombin	Homo sapiens	0-8
23494945-11	2013	This indicates the need for identification of RLS with IDA and consideration of appropriate therapeutic interventions for this sizeable subgroup: either aggressive iron treatment to reduce the RLS symptoms or medications for RLS or both.	Iron	164-168	RLS1	Homo sapiens	193-196
23601537-3	2013	The results demonstrate that the modifications caused by ultra-short laser pulses and by iron affect the tryptophan residues of apolipoprotein B-100 (Apo-B), slightly decreasing fluorescent lifetimes, with almost no modifications in pre-exponential factors, indicating preservation of structural properties around the fluorophore.	Iron	89-93	apolipoprotein B	Homo sapiens	128-148
23601537-3	2013	The results demonstrate that the modifications caused by ultra-short laser pulses and by iron affect the tryptophan residues of apolipoprotein B-100 (Apo-B), slightly decreasing fluorescent lifetimes, with almost no modifications in pre-exponential factors, indicating preservation of structural properties around the fluorophore.	Iron	89-93	apolipoprotein B	Homo sapiens	150-155
23593390-11	2013	Restricted-iron adult rats showed an increase in heart Ftl mRNA and the enriched-iron adult rats showed an increase in liver nuclear factor erythroid derived 2 like 2 (Nfe2l2) and Il1b mRNAs and in gut divalent metal transporter-1 mRNA (Slc11a2) relative to the control adult group.	Iron	81-85	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-166
23593390-11	2013	Restricted-iron adult rats showed an increase in heart Ftl mRNA and the enriched-iron adult rats showed an increase in liver nuclear factor erythroid derived 2 like 2 (Nfe2l2) and Il1b mRNAs and in gut divalent metal transporter-1 mRNA (Slc11a2) relative to the control adult group.	Iron	81-85	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-174
23593390-11	2013	Restricted-iron adult rats showed an increase in heart Ftl mRNA and the enriched-iron adult rats showed an increase in liver nuclear factor erythroid derived 2 like 2 (Nfe2l2) and Il1b mRNAs and in gut divalent metal transporter-1 mRNA (Slc11a2) relative to the control adult group.	Iron	81-85	interleukin 1 beta	Rattus norvegicus	180-184
23404507-7	2013	Whereas JAK3 and Fes marginally activate PLD2 in non-transformed cells, these kinases greatly enhance (&gt;200%) PLD activity following protein-protein interaction through the SH2 domain and the Tyr-415 residue of PLD2.	Iron	17-20	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	41-44
23494945-2	2013	Despite a clear relation between low peripheral iron and increased prevalence and severity of RLS, the prevalence and clinical significance of RLS in iron-deficient anemic (IDA) populations is unknown.	Iron	48-52	RLS1	Homo sapiens	94-97
23494945-11	2013	This indicates the need for identification of RLS with IDA and consideration of appropriate therapeutic interventions for this sizeable subgroup: either aggressive iron treatment to reduce the RLS symptoms or medications for RLS or both.	Iron	164-168	RLS1	Homo sapiens	193-196
23514038-3	2013	Brz2001 is a brassinosteroid biosynthesis inhibitor in the less-soluble triazole series of compounds that targets DWARF4, a cytochrome P450 (Cyp450) monooxygenase containing heme and iron.	Iron	183-187	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	141-147
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	51-55	amyloid beta precursor protein	Homo sapiens	6-31
23246125-0	2013	The relationship between red cell distribution width with erythropoietin resistance in iron replete hemodialysis patients.	Iron	87-91	erythropoietin	Homo sapiens	58-72
23246125-3	2013	Thus in the current study we tested the hypothesis that RDW and erythropoietin resistance as determined by erythropoiesis stimulating agents (ESA) hyporesponsiveness index (EHRI) may be related with each other in iron replete HD patients.	Iron	213-217	erythropoietin	Homo sapiens	64-78
23241313-0	2013	Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia.	Iron	0-4	lipoprotein lipase	Rattus norvegicus	21-39
23241313-7	2013	Likewise, LPL was lower in carbonyl iron-fed rats compared to controls (2.4 vs. 3.7 mM/min; P=0.017).	Iron	36-40	lipoprotein lipase	Rattus norvegicus	10-13
23241313-8	2013	Direct addition of iron to serum ex vivo or recombinant LPL in vitro decreased enzymatic activity in a dose-dependent manner.	Iron	19-23	lipoprotein lipase	Rattus norvegicus	56-59
22929029-3	2013	RLS susceptibility also has been related to iron.	Iron	44-48	RLS1	Homo sapiens	0-3
22929029-6	2013	Two population cohorts (KORA F3 and F4 with together n = 3447) were tested for association of six known RLS loci with iron, ferritin, transferrin, transferrin-saturation, and soluble transferrin receptor.	Iron	118-122	RLS1	Homo sapiens	104-107
22929029-12	2013	In conclusion, the correlation between RLS and iron parameters in serum may be weaker than assumed.	Iron	47-51	RLS1	Homo sapiens	39-42
23097160-2	2013	Iron chelators have therefore been used for inducing HIF-1alpha expression by inhibiting the hydroxylases.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	51-55	amyloid beta precursor protein	Homo sapiens	33-37
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	51-55	amyloid beta precursor protein	Homo sapiens	194-198
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	amyloid beta precursor protein	Homo sapiens	6-31
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	amyloid beta precursor protein	Homo sapiens	33-37
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	amyloid beta precursor protein	Homo sapiens	194-198
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	amyloid beta precursor protein	Homo sapiens	6-31
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	amyloid beta precursor protein	Homo sapiens	33-37
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	amyloid beta precursor protein	Homo sapiens	194-198
23350672-8	2013	Hemopexin sequesters heme, thus preventing unregulated heme uptake that leads to toxicity; it safely delivers heme to neuronal cells; and it activates the induction of proteins including HO1 and hAPP that keep heme and iron at safe levels in neurons.	Iron	219-223	amyloid beta precursor protein	Homo sapiens	195-199
23107390-1	2013	OBJECTIVE: Several epidemiological studies have reported that high concentrations of circulating ferritin, a marker of iron stores, are related to insulin resistance (IR); however, questions remain regarding inconsistent data between Asian men and women and the inadequate consideration of potential confounding effects on the relationship between ferritin and IR.	Iron	119-123	insulin	Homo sapiens	147-154
23416043-3	2013	Previous work from our laboratory has shown that beta-amyloid peptide (Abeta) aggregation was strongly influenced by the conjugation of the peptide with few metal ions (aluminum, copper, zinc, and iron) that are found in high concentrations in the senile plaque core.	Iron	197-201	amyloid beta precursor protein	Homo sapiens	49-69
23438894-0	2013	PGC-1alpha regulates hepatic hepcidin expression and iron homeostasis in response to inflammation.	Iron	53-57	PPARG coactivator 1 alpha	Homo sapiens	0-10
23438894-7	2013	In contrast, knockdown of PGC-1alpha exaggerates LPS-induced HAMP expression and iron dysregulation.	Iron	81-85	PPARG coactivator 1 alpha	Homo sapiens	26-36
23438894-10	2013	Our data suggest a critical role for PGC-1alpha in the regulation of hepatic HAMP expression and iron homeostasis under inflammatory circumstances.	Iron	97-101	PPARG coactivator 1 alpha	Homo sapiens	37-47
23506870-7	2013	Both SLC11A1 and SLC11A2 play an important role in macrophage iron recycling.	Iron	62-66	solute carrier family 11 member 1	Homo sapiens	5-12
23506870-8	2013	SLC11A2 also transports iron into the cytosol across the membrane of endocytotic vesicles of the transferrin receptor-cycle.	Iron	24-28	transferrin	Homo sapiens	97-108
22982299-3	2013	Amyloid beta is a metal binding protein and copper, zinc and iron promote amyloid beta oligomer formation.	Iron	61-65	amyloid beta precursor protein	Homo sapiens	0-12
22982299-3	2013	Amyloid beta is a metal binding protein and copper, zinc and iron promote amyloid beta oligomer formation.	Iron	61-65	amyloid beta precursor protein	Homo sapiens	74-86
22982299-6	2013	Amyloid beta can become pro-oxidant and when complexed to copper or iron it can generate hydrogen peroxide.	Iron	68-72	amyloid beta precursor protein	Homo sapiens	0-12
23391270-1	2013	BACKGROUND: Unbound iron binding capacity (UIBC) in serum, which is s-total iron binding capacity (2 times s- transferrin) minus s-iron, may be a more accurate marker of empty iron stores than serum transferrin saturation.	Iron	20-24	transferrin	Homo sapiens	110-121
23391270-1	2013	BACKGROUND: Unbound iron binding capacity (UIBC) in serum, which is s-total iron binding capacity (2 times s- transferrin) minus s-iron, may be a more accurate marker of empty iron stores than serum transferrin saturation.	Iron	76-80	transferrin	Homo sapiens	110-121
23391270-1	2013	BACKGROUND: Unbound iron binding capacity (UIBC) in serum, which is s-total iron binding capacity (2 times s- transferrin) minus s-iron, may be a more accurate marker of empty iron stores than serum transferrin saturation.	Iron	76-80	transferrin	Homo sapiens	110-121
23391270-1	2013	BACKGROUND: Unbound iron binding capacity (UIBC) in serum, which is s-total iron binding capacity (2 times s- transferrin) minus s-iron, may be a more accurate marker of empty iron stores than serum transferrin saturation.	Iron	76-80	transferrin	Homo sapiens	110-121
23391270-8	2013	CONCLUSION: When diagnosing empty iron stores calculation of s-UIBC is a better way to utilize the information in s-iron and s-transferrin than the calculation of s-transferrin saturation.	Iron	34-38	transferrin	Homo sapiens	127-138
23391270-8	2013	CONCLUSION: When diagnosing empty iron stores calculation of s-UIBC is a better way to utilize the information in s-iron and s-transferrin than the calculation of s-transferrin saturation.	Iron	34-38	transferrin	Homo sapiens	165-176
23506615-9	2013	CONCLUSIONS: Our results demonstrate that RGE has the ability to protect cells from AA + iron-induced ROS production and mitochondrial impairment through AMPK activation.	Iron	89-93	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	154-158
23349391-6	2013	In an acute cynomolgus monkey model of interleukin 6 (IL-6)-induced hypoferremia, NOX-H94 inhibited serum iron reduction completely.	Iron	106-110	interleukin-6	Macaca fascicularis	39-52
23349391-6	2013	In an acute cynomolgus monkey model of interleukin 6 (IL-6)-induced hypoferremia, NOX-H94 inhibited serum iron reduction completely.	Iron	106-110	interleukin-6	Macaca fascicularis	54-58
23373840-0	2013	Mechanistic insights on the ortho-hydroxylation of aromatic compounds by non-heme iron complex: a computational case study on the comparative oxidative ability of ferric-hydroperoxo and high-valent Fe(IV) O and Fe(V) O intermediates.	Iron	82-86	FEV transcription factor, ETS family member	Homo sapiens	211-216
23373840-0	2013	Mechanistic insights on the ortho-hydroxylation of aromatic compounds by non-heme iron complex: a computational case study on the comparative oxidative ability of ferric-hydroperoxo and high-valent Fe(IV) O and Fe(V) O intermediates.	Iron	198-200	FEV transcription factor, ETS family member	Homo sapiens	211-216
23473030-3	2013	Iron plays a direct and causal role in diabetes pathogenesis mediated both by beta cell failure and insulin resistance.	Iron	0-4	insulin	Homo sapiens	100-107
23416069-5	2013	Silencing of Snx3 results in anemia and hemoglobin defects in vertebrates due to impaired transferrin (Tf)-mediated iron uptake and its accumulation in early endosomes.	Iron	116-120	transferrin	Homo sapiens	90-101
23416069-5	2013	Silencing of Snx3 results in anemia and hemoglobin defects in vertebrates due to impaired transferrin (Tf)-mediated iron uptake and its accumulation in early endosomes.	Iron	116-120	transferrin	Homo sapiens	103-105
23416069-6	2013	This impaired iron assimilation can be complemented with non-Tf iron chelates.	Iron	14-18	transferrin	Homo sapiens	61-63
23579062-4	2013	Although there are many reports of hematopoietic stem cells being labeled with SPIO, there is some controversy regarding the efficiency of this and whether undifferentiated CD34+ progenitor (stem) cells are able to take up iron in the absence of a transfection agent to enhance the process.	Iron	223-227	CD34 molecule	Homo sapiens	173-177
23586717-6	2013	Further studies indicate that the iron-loaded IscA could act as an iron donor for the assembly of iron-sulfur clusters in the scaffold protein IscU in vitro.	Iron	34-38	iron-sulfur cluster assembly enzyme	Homo sapiens	143-147
23586717-6	2013	Further studies indicate that the iron-loaded IscA could act as an iron donor for the assembly of iron-sulfur clusters in the scaffold protein IscU in vitro.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	143-147
23586717-6	2013	Further studies indicate that the iron-loaded IscA could act as an iron donor for the assembly of iron-sulfur clusters in the scaffold protein IscU in vitro.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	143-147
23377899-2	2013	Circulating catalytic iron ("free" iron) is that which is not bound to transferrin or ferritin and is available to generate reactive oxygen species that may have deleterious vascular effects.	Iron	22-26	transferrin	Homo sapiens	71-82
23377899-2	2013	Circulating catalytic iron ("free" iron) is that which is not bound to transferrin or ferritin and is available to generate reactive oxygen species that may have deleterious vascular effects.	Iron	35-39	transferrin	Homo sapiens	71-82
23235478-4	2013	The presence of iron-saturated Tf (holo-Tf; 4 h) reduced V2R binding sites at the cell surface by up to 33% while iron-free (apo-Tf) had no effect.	Iron	16-20	arginine vasopressin receptor 2	Rattus norvegicus	57-60
23274316-13	2013	iron should be preferred at least in five scenarios: intolerance to oral iron, severe anemia, failure of oral therapy, need for a quick recovery, and use of erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	157-171
23579062-10	2013	Iron labeling of CD34+ cells in this manner does not affect cell viability and does not appear to affect the potential of the cells to grow in culture.	Iron	0-4	CD34 molecule	Homo sapiens	17-21
23579062-11	2013	Iron-labeled CD34+ cells can be visualized in vitro on 3-T magnetic resonance image scanning.	Iron	0-4	CD34 molecule	Homo sapiens	13-17
22618893-10	2013	Women with 25-hydroxyvitamin D &gt;= 50 nmol/L compared with 25-hydroxyvitamin D &lt; 50 nmol/L showed a higher increase in transferrin saturation (a marker of iron supply to tissues) during iron recovery.	Iron	160-164	transferrin	Homo sapiens	124-135
23372018-3	2013	We have previously shown in a mouse model of hereditary iron overload that cytosolic iron levels affected mitochondrial manganese availability, MnSOD activity, and insulin secretion.	Iron	85-89	superoxide dismutase 2, mitochondrial	Mus musculus	144-149
22618893-10	2013	Women with 25-hydroxyvitamin D &gt;= 50 nmol/L compared with 25-hydroxyvitamin D &lt; 50 nmol/L showed a higher increase in transferrin saturation (a marker of iron supply to tissues) during iron recovery.	Iron	191-195	transferrin	Homo sapiens	124-135
23469912-4	2013	Haptoglobin (Hp) is a plasma protein that binds free hemoglobin and prevents heme-iron mediated oxidation.	Iron	82-86	haptoglobin	Homo sapiens	0-11
23334161-6	2013	All residue 41 variants decreased the pK                 (a) of a structural transition of oxidized cytochrome c to the alkaline conformation, and this correlated with a destabilization of the interaction of Met-80 with the heme iron(III) at physiological pH.	Iron	229-233	cytochrome c, somatic	Homo sapiens	100-112
23219873-0	2013	Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells.	Iron	85-89	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
23219873-5	2013	Animals lacking Sod2 expression in erythroid precursors also displayed extramedullary hematopoiesis and systemic iron redistribution.	Iron	113-117	superoxide dismutase 2, mitochondrial	Mus musculus	16-20
23280783-10	2013	We conclude that SEM is a very effective tool for the visualization of circulatory consequences of the interaction of iron-induced hydroxyl radicals with human fibrinogen.	Iron	118-122	fibrinogen beta chain	Homo sapiens	160-170
23429462-7	2013	Patients treated with steroids, immunomodulators, and/or anti-tumor necrosis factor drugs were more frequently treated with iron supplements when compared with those not treated with any medications (35.0% versus 20.9%, odds ratio, 1.94; P &lt; 0.001).	Iron	124-128	tumor necrosis factor	Homo sapiens	62-83
23371041-11	2013	Our results suggest that, in patients with solid tumors and CT-induced anemia, high CRP levels at treatment initiation predict a poor response to treatment with ESA and iron, independently from anemia severity at therapy initiation and from other patient and disease characteristics.	Iron	169-173	C-reactive protein	Homo sapiens	84-87
23403918-4	2013	Tf is an iron-transporting protein, and is able to carry other metal ions as well.	Iron	9-13	transferrin	Homo sapiens	0-2
23403918-9	2013	Results have shown that the amount of IGFBP-3 involved in the complex formation with Tf in healthy persons was 5.4 +- 1.02 nM and iron ions were substantial for their formation and isolation without employment of harsh conditions.	Iron	130-134	transferrin	Homo sapiens	85-87
23480322-12	2013	Iron status was inversely associated with weight gain during risperidone treatment and with interleukin-6.	Iron	0-4	interleukin 6	Homo sapiens	92-105
22707233-9	2013	An inverse correlation was observed between the haptoglobin and free iron serum levels in diabetic rats.	Iron	69-73	haptoglobin	Rattus norvegicus	48-59
22707233-10	2013	The higher levels of haptoglobin during the first 2 weeks were accompanied by a lower level of free iron.	Iron	100-104	haptoglobin	Rattus norvegicus	21-32
23280783-11	2013	Furthermore, this novel fibrinogen model provides a convenient method to study the interactions of the intramolecular and intermolecular hydrophobic forces responsible for the maintenance of the tertiary structure of native fibrin(ogen) and the prevention of iron-induced DMDs formation by hydrophilic agents.	Iron	259-263	fibrinogen beta chain	Homo sapiens	24-34
23289528-0	2013	Abeta interacts with both the iron center and the porphyrin ring of heme: mechanism of heme"s action on Abeta aggregation and disaggregation.	Iron	30-34	amyloid beta precursor protein	Homo sapiens	0-5
23202722-3	2013	TfR is regulated by both iron and nitric oxide (NO), the molecule produced by endothelial nitric oxide synthase (eNOS).	Iron	25-29	nitric oxide synthase 3	Homo sapiens	78-111
23150584-5	2013	A conserved histidine in HCCS (His154) provided the key ligand to the heme iron.	Iron	75-79	holocytochrome c synthase	Homo sapiens	25-29
23433094-0	2013	The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis.	Iron	55-59	transmembrane serine protease 6	Homo sapiens	10-17
23433094-0	2013	The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis.	Iron	55-59	transmembrane serine protease 6	Homo sapiens	105-112
23433094-1	2013	BACKGROUND: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron metabolism, and erythropoiesis in chronic hemodialysis (CHD).	Iron	117-121	transmembrane serine protease 6	Homo sapiens	64-71
23433094-1	2013	BACKGROUND: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron metabolism, and erythropoiesis in chronic hemodialysis (CHD).	Iron	214-218	transmembrane serine protease 6	Homo sapiens	64-71
23276205-2	2013	Neuronal toxicity in AD has been linked to the interactions of amyloid-beta (Abeta) with metals, especially Zn(2+), Cu(2+), and Fe(3+), which leads to the production of reactive oxygen species.	Iron	128-130	amyloid beta precursor protein	Homo sapiens	63-75
23276205-2	2013	Neuronal toxicity in AD has been linked to the interactions of amyloid-beta (Abeta) with metals, especially Zn(2+), Cu(2+), and Fe(3+), which leads to the production of reactive oxygen species.	Iron	128-130	amyloid beta precursor protein	Homo sapiens	77-82
23426685-3	2013	Previous studies in our laboratory showed that NMDA receptor activation, via NO and Dexras1, physiologically stimulates DMT1, the major iron importer.	Iron	136-140	RAS, dexamethasone-induced 1	Mus musculus	84-91
23426685-4	2013	A membrane-permeable iron chelator substantially reduces NMDA excitotoxicity, suggesting that Dexras1-mediated iron influx plays a crucial role in NMDA/NO-mediated cell death.	Iron	21-25	RAS, dexamethasone-induced 1	Mus musculus	94-101
23426685-4	2013	A membrane-permeable iron chelator substantially reduces NMDA excitotoxicity, suggesting that Dexras1-mediated iron influx plays a crucial role in NMDA/NO-mediated cell death.	Iron	111-115	RAS, dexamethasone-induced 1	Mus musculus	94-101
23426685-7	2013	Thus, Dexras1 appears to mediate NMDA-elicited neurotoxicity via NO and iron influx.	Iron	72-76	RAS, dexamethasone-induced 1	Mus musculus	6-13
23289528-5	2013	Recent research has shown that heme binds preferentially to the His(13) residue of Abeta with the iron center, while the hydrophobic domain of Abeta is also able to bind to heme.	Iron	98-102	amyloid beta precursor protein	Homo sapiens	83-88
23289528-6	2013	Herein, absorption spectrometric, Thioflavin T fluorescence, and circular dichroism spectroscopic and transmission electron microscopic measurements revealed that the iron center is not required for the inhibition of Abeta aggregation but do influence the binding affinity of heme toward Abeta and the dismantlement rate and degree of the Abeta aggregates.	Iron	167-171	amyloid beta precursor protein	Homo sapiens	288-293
23316015-1	2013	Pumping iron: Raymond"s group has identified and described the molecular details of an ABC transporter.	Iron	8-12	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	87-102
23395174-5	2013	Expression of the iron transport genes DCytb, Dmt1, and ferroportin, as well as other HIF-2alpha targets, is enhanced in Irp1(-/-) duodenum.	Iron	18-22	cytochrome b reductase 1	Mus musculus	39-44
23151668-5	2013	Following analysis of small-molecule iron complexes and application of non-denaturing protein mass spectrometry to assess PHD2 iron inhibitor stoichiometry, selected diacylhydrazines were identified as PHD2 inhibitors that induce the binding of a second iron ion.	Iron	37-41	egl-9 family hypoxia inducible factor 1	Homo sapiens	202-206
23151668-5	2013	Following analysis of small-molecule iron complexes and application of non-denaturing protein mass spectrometry to assess PHD2 iron inhibitor stoichiometry, selected diacylhydrazines were identified as PHD2 inhibitors that induce the binding of a second iron ion.	Iron	127-131	egl-9 family hypoxia inducible factor 1	Homo sapiens	122-126
23151668-5	2013	Following analysis of small-molecule iron complexes and application of non-denaturing protein mass spectrometry to assess PHD2 iron inhibitor stoichiometry, selected diacylhydrazines were identified as PHD2 inhibitors that induce the binding of a second iron ion.	Iron	127-131	egl-9 family hypoxia inducible factor 1	Homo sapiens	202-206
23151668-5	2013	Following analysis of small-molecule iron complexes and application of non-denaturing protein mass spectrometry to assess PHD2 iron inhibitor stoichiometry, selected diacylhydrazines were identified as PHD2 inhibitors that induce the binding of a second iron ion.	Iron	127-131	egl-9 family hypoxia inducible factor 1	Homo sapiens	122-126
23151668-5	2013	Following analysis of small-molecule iron complexes and application of non-denaturing protein mass spectrometry to assess PHD2 iron inhibitor stoichiometry, selected diacylhydrazines were identified as PHD2 inhibitors that induce the binding of a second iron ion.	Iron	127-131	egl-9 family hypoxia inducible factor 1	Homo sapiens	202-206
23219683-7	2013	The perturbation in Fe homeostasis may contribute to the neurotoxicology consequences induced by Pb exposure, and FP1 may play a role in Pb-induced Fe cumulation in the brain.	Iron	148-150	solute carrier family 40 member 1	Rattus norvegicus	114-117
27683448-2	2013	The aim of this study was to test the hypothesis that lowered serum transferrin level may contribute to functional anemia and erythropoietin hypo responsiveness by the failure to transport accumulated tissue iron to the relevant target tissue.	Iron	208-212	transferrin	Homo sapiens	68-79
27683448-2	2013	The aim of this study was to test the hypothesis that lowered serum transferrin level may contribute to functional anemia and erythropoietin hypo responsiveness by the failure to transport accumulated tissue iron to the relevant target tissue.	Iron	208-212	erythropoietin	Homo sapiens	126-140
27683448-14	2013	CONCLUSIONS: The lowered transferrin level prevents the proper transport of the iron to the hematopoietic sites, which may be a reason for the low hemoglobin synthesis and also for the development of erythropoietin hypo responsiveness in some of the dialysis patients.	Iron	80-84	transferrin	Homo sapiens	25-36
27683448-14	2013	CONCLUSIONS: The lowered transferrin level prevents the proper transport of the iron to the hematopoietic sites, which may be a reason for the low hemoglobin synthesis and also for the development of erythropoietin hypo responsiveness in some of the dialysis patients.	Iron	80-84	erythropoietin	Homo sapiens	200-214
23282799-1	2013	Redox active metals (Fe and Cu) and cofactors (heme) bind to Abeta peptides and react with O(2) in their reduced state leading to oxidative stress in the brain.	Iron	21-23	amyloid beta precursor protein	Homo sapiens	61-66
23160040-0	2013	Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 transcription mediated by hypoxia inducible factor-1.	Iron	17-21	insulin	Homo sapiens	0-7
23418762-15	2013	If iron avidity is not suspected, it may mimic undertreatment with persistently elevated transferrin saturation.	Iron	3-7	transferrin	Homo sapiens	89-100
23160040-0	2013	Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 transcription mediated by hypoxia inducible factor-1.	Iron	17-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-140
23160040-1	2013	Hepatic iron is known to regulate insulin signaling pathways and to influence insulin sensitivity in insulin resistance (IR) patients.	Iron	8-12	insulin	Homo sapiens	34-41
23160040-1	2013	Hepatic iron is known to regulate insulin signaling pathways and to influence insulin sensitivity in insulin resistance (IR) patients.	Iron	8-12	insulin	Homo sapiens	78-85
23160040-1	2013	Hepatic iron is known to regulate insulin signaling pathways and to influence insulin sensitivity in insulin resistance (IR) patients.	Iron	8-12	insulin	Homo sapiens	78-85
23160040-3	2013	Here, we report that insulin promotes transferrin-bound iron uptake but shows no influence on non transferrin-bound iron uptake in human hepatic HepG2 cells.	Iron	56-60	insulin	Homo sapiens	21-28
23160040-3	2013	Here, we report that insulin promotes transferrin-bound iron uptake but shows no influence on non transferrin-bound iron uptake in human hepatic HepG2 cells.	Iron	56-60	transferrin	Homo sapiens	38-49
23160040-8	2013	Transfection of cDNA expressing stable form of HIF-1alpha reversed the increased TfR1 expression and iron uptake.	Iron	101-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
23160040-9	2013	These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent transcriptional regulation of TfR1.	Iron	57-61	insulin	Homo sapiens	38-45
23160040-9	2013	These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent transcriptional regulation of TfR1.	Iron	57-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-79
23278483-0	2013	A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia -- response to Jaspers et al.	Iron	80-84	transmembrane serine protease 6	Homo sapiens	40-52
23216605-0	2013	A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia (IRIDA).	Iron	80-84	transmembrane serine protease 6	Homo sapiens	40-52
23216605-0	2013	A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia (IRIDA).	Iron	80-84	transmembrane serine protease 6	Homo sapiens	54-61
23151373-7	2013	plasma non-transferrin-bound iron (NTBI) declined from 3.10+-0.25muM to 2.15+-0.29muM (p=0.028).	Iron	29-33	transferrin	Homo sapiens	11-22
23278483-0	2013	A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia -- response to Jaspers et al.	Iron	80-84	transmembrane serine protease 6	Homo sapiens	54-61
22961568-6	2013	Using linear regression analyses, we investigated the difference in adipocyte IR or adiponectin (in %) according to differences in iron metabolism markers.	Iron	131-135	adiponectin, C1Q and collagen domain containing	Homo sapiens	78-95
23433116-4	2013	The formation of carbonyl compounds and the release of iron were obtained in salsolinol- treated cytochrome c.	Iron	55-59	cytochrome c, somatic	Homo sapiens	97-109
23433116-5	2013	Salsolinol also led to the release of iron from cytochrome c.	Iron	38-42	cytochrome c, somatic	Homo sapiens	48-60
23433116-6	2013	Reactive oxygen species (ROS) scavengers and iron specific chelator inhibited the salsolinol-mediated cytochrome c modification and carbonyl compound formation.	Iron	45-49	cytochrome c, somatic	Homo sapiens	102-114
23433116-7	2013	It is suggested that oxidative damage of cytochrome c by salsolinol might induce the increase of iron content in cells, subsequently leading to the deleterious condition which was observed.	Iron	97-101	cytochrome c, somatic	Homo sapiens	41-53
23486578-0	2013	Thiol antioxidants in combination with vitamin B12 induce apoptotic death of human lymphocytic leukemia cells by destabilization of lysosomes with the involvement of iron ions.	Iron	166-170	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	47-50
22961568-0	2013	Iron metabolism is associated with adipocyte insulin resistance and plasma adiponectin: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study.	Iron	0-4	insulin	Homo sapiens	45-52
22961568-0	2013	Iron metabolism is associated with adipocyte insulin resistance and plasma adiponectin: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study.	Iron	0-4	adiponectin, C1Q and collagen domain containing	Homo sapiens	75-86
22961568-3	2013	We therefore investigated whether markers of iron metabolism were associated with adipocyte IR and plasma adiponectin.	Iron	45-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	106-117
22961568-10	2013	CONCLUSIONS: The observed associations of several markers of iron metabolism with adipocyte IR and adiponectin suggest that factors related to iron and iron metabolism may contribute to adipocyte IR early in the pathogenesis of T2DM.	Iron	143-147	adiponectin, C1Q and collagen domain containing	Homo sapiens	99-110
22961568-10	2013	CONCLUSIONS: The observed associations of several markers of iron metabolism with adipocyte IR and adiponectin suggest that factors related to iron and iron metabolism may contribute to adipocyte IR early in the pathogenesis of T2DM.	Iron	143-147	adiponectin, C1Q and collagen domain containing	Homo sapiens	99-110
22416811-1	2013	AIMS: Mutations in the pantothenate kinase 2 gene (PANK2) are responsible for the most common type of neurodegeneration with brain iron accumulation (NBIA), known as pantothenate kinase-associated neurodegeneration (PKAN).	Iron	131-135	pantothenate kinase 2	Homo sapiens	23-44
22241739-9	2013	In addition, significant inductive effects of iron-deficient diet on Dcytb and DMT1 mRNA expression in the duodenum were noted with more pronounced effects in Hamp (-/-) mice compared with controls.	Iron	46-50	cytochrome b reductase 1	Mus musculus	69-74
23178241-1	2013	Two single nucleotide polymorphisms (SNPs) in the Human Hemochromatosis (HFE) gene, C282Y and H63D, are the major variants associated to altered iron status and it is well known that these mutations are in linkage disequilibrium with certain Human Leukocyte Antigen (HLA)-A alleles.	Iron	145-149	major histocompatibility complex, class I, A	Homo sapiens	248-273
22934738-18	2013	We suggest that PLA2G6 should be screened in any patient exhibiting progressive gait disturbance, bradykinesia, dysarthria, tremors, mood/behavior changes or cognitive decline, especially when associated with cerebellar atrophy and/or iron accumulation and/or cerebral atrophy.	Iron	235-239	phospholipase A2 group VI	Homo sapiens	16-22
22274938-5	2013	While expression of genes related to iron storage such as ferritin 1 and ferritin 2 was downregulated.	Iron	37-41	ferritin-1, chloroplastic	Nicotiana tabacum	58-68
22274938-5	2013	While expression of genes related to iron storage such as ferritin 1 and ferritin 2 was downregulated.	Iron	37-41	ferritin-1, chloroplastic	Nicotiana tabacum	58-66
23166001-0	2013	PANK2 and C19orf12 mutations are common causes of neurodegeneration with brain iron accumulation.	Iron	79-83	pantothenate kinase 2	Homo sapiens	0-5
22416811-1	2013	AIMS: Mutations in the pantothenate kinase 2 gene (PANK2) are responsible for the most common type of neurodegeneration with brain iron accumulation (NBIA), known as pantothenate kinase-associated neurodegeneration (PKAN).	Iron	131-135	pantothenate kinase 2	Homo sapiens	51-56
22738721-4	2013	Transferrin and transferrin saturation levels found increased in PD subjects underline the concept to extend the iron study in PD to iron master proteins.	Iron	133-137	transferrin	Homo sapiens	0-11
22738721-4	2013	Transferrin and transferrin saturation levels found increased in PD subjects underline the concept to extend the iron study in PD to iron master proteins.	Iron	113-117	transferrin	Homo sapiens	0-11
22738721-4	2013	Transferrin and transferrin saturation levels found increased in PD subjects underline the concept to extend the iron study in PD to iron master proteins.	Iron	113-117	transferrin	Homo sapiens	16-27
22738721-4	2013	Transferrin and transferrin saturation levels found increased in PD subjects underline the concept to extend the iron study in PD to iron master proteins.	Iron	133-137	transferrin	Homo sapiens	16-27
22416811-1	2013	AIMS: Mutations in the pantothenate kinase 2 gene (PANK2) are responsible for the most common type of neurodegeneration with brain iron accumulation (NBIA), known as pantothenate kinase-associated neurodegeneration (PKAN).	Iron	131-135	pantothenate kinase 2	Homo sapiens	216-220
23399663-5	2013	Plasma iron and transferrin saturation were affected by an interaction between dietary fat and iron.	Iron	95-99	transferrin	Rattus norvegicus	16-27
23252371-0	2013	The 14-3-3 protein GENERAL REGULATORY FACTOR11 (GRF11) acts downstream of nitric oxide to regulate iron acquisition in Arabidopsis thaliana.	Iron	99-103	general regulatory factor 11	Arabidopsis thaliana	19-46
23252371-0	2013	The 14-3-3 protein GENERAL REGULATORY FACTOR11 (GRF11) acts downstream of nitric oxide to regulate iron acquisition in Arabidopsis thaliana.	Iron	99-103	general regulatory factor 11	Arabidopsis thaliana	48-53
23252371-1	2013	Here we report the function of a general regulatory factor, GENERAL REGULATORY FACTOR11 (GRF11), in terms of the iron (Fe) deficiency response.	Iron	113-117	general regulatory factor 11	Arabidopsis thaliana	60-87
23252371-1	2013	Here we report the function of a general regulatory factor, GENERAL REGULATORY FACTOR11 (GRF11), in terms of the iron (Fe) deficiency response.	Iron	113-117	general regulatory factor 11	Arabidopsis thaliana	89-94
23252371-1	2013	Here we report the function of a general regulatory factor, GENERAL REGULATORY FACTOR11 (GRF11), in terms of the iron (Fe) deficiency response.	Iron	119-121	general regulatory factor 11	Arabidopsis thaliana	60-87
23252371-1	2013	Here we report the function of a general regulatory factor, GENERAL REGULATORY FACTOR11 (GRF11), in terms of the iron (Fe) deficiency response.	Iron	119-121	general regulatory factor 11	Arabidopsis thaliana	89-94
23252371-2	2013	Physiological and molecular responses of the loss-of-function Arabidopsis thaliana grf11 mutant to Fe supply were investigated.	Iron	99-101	general regulatory factor 11	Arabidopsis thaliana	83-88
23161089-6	2013	Assay of the stoichiometry of metal binding to the purified rh-HSPA5 showed that one molecule of the rh-HSPA5 could chelate 1 or 2 Cu, 13 iron (Fe), 5 zinc (Zn) and 10 lead (Pb) ions but not manganese (Mn).	Iron	138-142	heat shock protein family A (Hsp70) member 5	Homo sapiens	63-68
23161089-6	2013	Assay of the stoichiometry of metal binding to the purified rh-HSPA5 showed that one molecule of the rh-HSPA5 could chelate 1 or 2 Cu, 13 iron (Fe), 5 zinc (Zn) and 10 lead (Pb) ions but not manganese (Mn).	Iron	138-142	heat shock protein family A (Hsp70) member 5	Homo sapiens	104-109
23161089-6	2013	Assay of the stoichiometry of metal binding to the purified rh-HSPA5 showed that one molecule of the rh-HSPA5 could chelate 1 or 2 Cu, 13 iron (Fe), 5 zinc (Zn) and 10 lead (Pb) ions but not manganese (Mn).	Iron	144-146	heat shock protein family A (Hsp70) member 5	Homo sapiens	63-68
23161089-6	2013	Assay of the stoichiometry of metal binding to the purified rh-HSPA5 showed that one molecule of the rh-HSPA5 could chelate 1 or 2 Cu, 13 iron (Fe), 5 zinc (Zn) and 10 lead (Pb) ions but not manganese (Mn).	Iron	144-146	heat shock protein family A (Hsp70) member 5	Homo sapiens	104-109
23399663-10	2013	The expression of iron regulatory gene HAMP was not increased in the HF diet groups.	Iron	18-22	hepcidin antimicrobial peptide	Rattus norvegicus	39-43
23543809-7	2013	Treatment with an iron chelator, deferoxamine, attenuated the ICH-induced reduction in DARPP-32 protein levels.	Iron	18-22	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	87-95
23264567-4	2013	We specifically focus on (1) RNA interactions with fragile X mental retardation protein FMRP; (2) protein sequestration caused by CGG repeats; (3) noncoding transcripts regulated by TAR DNA-binding protein 43 TDP-43; (4) autogenous regulation of TDP-43 and FMRP; (5) iron-mediated expression of amyloid precursor protein APP and alpha-synuclein; (6) interactions between prions and RNA aptamers.	Iron	267-271	TAR DNA binding protein	Homo sapiens	182-208
23086747-7	2013	We found that as another important compensatory response to intracellular overload of iron ion, cells significantly downregulated the expressions of genes belonging to solute carrier family which are responsible for transferring many organic solutes into cells, such as Slc5a3 and Slc44a1, in order to prevent more organic solutes into cells and thus lower the intracellular osmosis.	Iron	86-90	solute carrier family 5 (inositol transporters), member 3	Mus musculus	270-276
23086747-7	2013	We found that as another important compensatory response to intracellular overload of iron ion, cells significantly downregulated the expressions of genes belonging to solute carrier family which are responsible for transferring many organic solutes into cells, such as Slc5a3 and Slc44a1, in order to prevent more organic solutes into cells and thus lower the intracellular osmosis.	Iron	86-90	solute carrier family 44, member 1	Mus musculus	281-288
23469783-8	2013	CONCLUSION: Iron overload can inhibit the proliferation of MSCs and induce their apoptosis through the generation of ROS, which is probably due to the stimulation of p38MAPK- p53 signaling pathway.	Iron	12-16	tumor protein p53	Homo sapiens	175-178
23469785-10	2013	CONCLUSION: The magnetic c-erbB-2 antisense probe can effectively transfect and specifically inhibit the expression of SK-Br-3 cell lines at the iron concentration of 25 mg/L.	Iron	145-149	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-33
23319530-1	2013	Iron-refractory iron-deficiency anemia (IRIDA) is an autosomal recessive disorder caused by mutations in TMPRSS6.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	105-112
23319530-6	2013	Whole exome sequencing identified in both patients compound heterozygous mutations of TMPRSS6 leading to p.G442R and p.E522K, 2 mutations previously reported to cause classic IRIDA, and no additional mutations in known iron-regulatory genes.	Iron	219-223	transmembrane serine protease 6	Homo sapiens	86-93
23319530-7	2013	Thus, the phenotype associated with the unique combination of mutations uncovered in both patients expands the spectrum of disease associated with TMPRSS6 mutations to include iron deficiency anemia that is accompanied by hyperferritinemia at initial presentation and is responsive to continued oral iron therapy.	Iron	176-180	transmembrane serine protease 6	Homo sapiens	147-154
23178912-3	2013	Since enhanced iron levels are discussed to participate in oxidative stress and neuronal death, we analyzed the expression levels of Fe-related mRNAs in a cell culture ALS model with the G93A mutation of SOD1.	Iron	133-135	superoxide dismutase 1	Homo sapiens	204-208
23440025-1	2012	Nitrogenase enzymes have evolved complex iron-sulfur (Fe-S) containing cofactors that most commonly contain molybdenum (MoFe, Nif) as a heterometal but also exist as vanadium (VFe, Vnf) and heterometal-independent (Fe-only, Anf) forms.	Iron	54-58	natriuretic peptide A	Homo sapiens	224-227
23440025-1	2012	Nitrogenase enzymes have evolved complex iron-sulfur (Fe-S) containing cofactors that most commonly contain molybdenum (MoFe, Nif) as a heterometal but also exist as vanadium (VFe, Vnf) and heterometal-independent (Fe-only, Anf) forms.	Iron	54-56	natriuretic peptide A	Homo sapiens	224-227
23178912-4	2013	We observed an increased total iron content in G93A-SOD1 SH-SY5Y neuroblastoma cells compared to wild-type (WT)-SOD1 cells.	Iron	31-35	superoxide dismutase 1	Homo sapiens	52-56
23178912-5	2013	mRNA expression for transferrin receptor 1 (TfR1) and divalent metal transporter 1 was increased in G93A-SOD1 cells, which was in accordance with higher iron uptake.	Iron	153-157	superoxide dismutase 1	Homo sapiens	105-109
23178912-7	2013	Expression levels of mitoferrin 1 and 2, frataxin, and iron-sulfur cluster scaffold protein were also significantly increased in G93A-SOD1 cells, suggesting higher mitochondrial iron import and utilization in biosynthetic pathways within the mitochondria.	Iron	55-59	superoxide dismutase 1	Homo sapiens	134-138
23178912-7	2013	Expression levels of mitoferrin 1 and 2, frataxin, and iron-sulfur cluster scaffold protein were also significantly increased in G93A-SOD1 cells, suggesting higher mitochondrial iron import and utilization in biosynthetic pathways within the mitochondria.	Iron	178-182	superoxide dismutase 1	Homo sapiens	134-138
23265191-4	2013	Here, by comparing the biochemical and spectroscopic properties of quaternary (ISCU/NFS1/ISD11/FXN) and ternary (ISCU/NFS1/ISD11) complexes, we show that FXN stabilizes the quaternary complex and controls iron entry to the complex through activation of cysteine desulfurization.	Iron	205-209	iron-sulfur cluster assembly enzyme	Homo sapiens	79-83
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Iron	257-261	transferrin	Homo sapiens	38-40
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Iron	257-261	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Iron	257-261	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Iron	257-261	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Iron	257-261	transferrin	Homo sapiens	62-64
23194060-9	2013	Substitution of synergistic anions of Tf from carbonate (holo-Tf) to oxalate (oxa-Tf) significantly increased the intracellular accumulation of the oxa-Tf-QDs as a result of (i) a delay in cellular removal triggered by oxalate (oxa-Tf)-induced endosomal Tf iron-release retardation and (ii) enhanced recycling of Tf-QD/TfR (Tf receptor) complexes from early endosomes to the plasma membrane.	Iron	257-261	transferrin	Homo sapiens	62-64
23265191-4	2013	Here, by comparing the biochemical and spectroscopic properties of quaternary (ISCU/NFS1/ISD11/FXN) and ternary (ISCU/NFS1/ISD11) complexes, we show that FXN stabilizes the quaternary complex and controls iron entry to the complex through activation of cysteine desulfurization.	Iron	205-209	LYR motif containing 4	Homo sapiens	89-94
23265191-4	2013	Here, by comparing the biochemical and spectroscopic properties of quaternary (ISCU/NFS1/ISD11/FXN) and ternary (ISCU/NFS1/ISD11) complexes, we show that FXN stabilizes the quaternary complex and controls iron entry to the complex through activation of cysteine desulfurization.	Iron	205-209	iron-sulfur cluster assembly enzyme	Homo sapiens	113-117
23265191-4	2013	Here, by comparing the biochemical and spectroscopic properties of quaternary (ISCU/NFS1/ISD11/FXN) and ternary (ISCU/NFS1/ISD11) complexes, we show that FXN stabilizes the quaternary complex and controls iron entry to the complex through activation of cysteine desulfurization.	Iron	205-209	LYR motif containing 4	Homo sapiens	123-128
23195599-1	2013	Aiming at reusing the SPC to save water resource and heat energy, a combination treatment process of UF/NF was applied to remove inorganic irons, suspended particles and little amount of organic contaminants in this article.	Iron	139-144	proline rich protein gene cluster	Homo sapiens	22-25
23252340-9	2013	It showed that more Fe atoms were coordinated with As atom in the monodentate complexes and the bidentate complexes of As(V)/As(III)-treated siderite under oxic conditions, in comparison with As(V)/As(III)-treated siderite under anoxic conditions and As(V)/As(III)-treated goethite.	Iron	20-22	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	119-124
23172354-4	2013	[Fe(II)(BP1)] catalyzed the oxidation of o-phenylenediamine with H(2)O(2) with enzyme-like kinetics (k(cat) = 1.0 min(-1), K(M) = 1.5 mM, k(cat)/k(uncat) = 90 000) and multiple turnover, while Fe(2+) or [Fe(bipy)(3)](2+) were inactive.	Iron	1-3	BP1	Homo sapiens	8-11
23137639-0	2013	Iron-sulfur cluster scaffold (ISCU) gene is duplicated in salmonid fish and tissue and temperature dependent expressed in rainbow trout.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	30-34
23137639-1	2013	The iron-sulfur cluster protein ISCU is a scaffold protein tasked with the building and mediation of iron-sulfur [Fe-S]-clusters.	Iron	4-8	iron-sulfur cluster assembly enzyme	Homo sapiens	32-36
23137639-1	2013	The iron-sulfur cluster protein ISCU is a scaffold protein tasked with the building and mediation of iron-sulfur [Fe-S]-clusters.	Iron	101-105	iron-sulfur cluster assembly enzyme	Homo sapiens	32-36
23137639-1	2013	The iron-sulfur cluster protein ISCU is a scaffold protein tasked with the building and mediation of iron-sulfur [Fe-S]-clusters.	Iron	114-118	iron-sulfur cluster assembly enzyme	Homo sapiens	32-36
23762920-11	2013	Therefore, supplemental iron therapy, either given orally or intravenously, is often needed among dialysis patients who receive recombinant human erythropoietin (EPO) or darbepoetin alfa treatment.	Iron	24-28	erythropoietin	Homo sapiens	146-160
23303302-5	2013	FE enhanced apoptosis in cancer cells that responded to treatment with three chemotherapeutic drugs with downregulation of the anti-apoptotic proteins Bcl-xL and Mcl-1.	Iron	0-2	BCL2 like 1	Homo sapiens	151-157
23281703-3	2013	Fth expression is regulated by iron level; therefore its localization can be used as a sensitive indicator for iron deposition.	Iron	31-35	ferritin heavy chain 1	Rattus norvegicus	0-3
23281703-3	2013	Fth expression is regulated by iron level; therefore its localization can be used as a sensitive indicator for iron deposition.	Iron	111-115	ferritin heavy chain 1	Rattus norvegicus	0-3
23762920-11	2013	Therefore, supplemental iron therapy, either given orally or intravenously, is often needed among dialysis patients who receive recombinant human erythropoietin (EPO) or darbepoetin alfa treatment.	Iron	24-28	erythropoietin	Homo sapiens	162-165
23117987-13	2013	Determination of Ft and TfR indirectly indicated that FPN1 might contribute to iron release from O-2A progenitor cells.	Iron	79-83	solute carrier family 40 member 1	Rattus norvegicus	54-58
23876871-2	2013	The Fe-S clusters are assembled by one of four distinct systems: NIF, SUF, ISC, and CIA machineries.	Iron	4-8	nuclear receptor coactivator 5	Homo sapiens	84-87
23117987-10	2013	The release of iron in O-2A progenitor cells was dramatically increased by the overexpressed FPN1 when compared with that of the control group.	Iron	15-19	solute carrier family 40 member 1	Rattus norvegicus	93-97
23117987-14	2013	We suggested that expression of FPN1 in O-2A progenitor cells might play a critical role in iron efflux from these cells.	Iron	92-96	solute carrier family 40 member 1	Rattus norvegicus	32-36
22713426-6	2013	DISCUSSION: Converging evidence from neuroimaging, autoptic and animal studies points towards dopamine dysregulation and iron metabolism alterations as the main contributors to RLS pathophysiology.	Iron	121-125	RLS1	Homo sapiens	177-180
23016877-8	2013	Our data indicate that IKK-NF-kappaB responds to changes in iron within the cell.	Iron	60-64	nuclear factor kappa B subunit 1	Homo sapiens	27-36
22992020-1	2013	HO1 (haem oxygenase 1) and Fpn (ferroportin) are key proteins for iron recycling from senescent red blood cells and therefore play a major role in controlling the bioavailability of iron for erythropoiesis.	Iron	66-70	heme oxygenase 1	Mus musculus	0-21
22992020-1	2013	HO1 (haem oxygenase 1) and Fpn (ferroportin) are key proteins for iron recycling from senescent red blood cells and therefore play a major role in controlling the bioavailability of iron for erythropoiesis.	Iron	182-186	heme oxygenase 1	Mus musculus	0-21
22992020-8	2013	Furthermore, we show that iron/haem-mediated toxicity are responsible for renal injury documented in the kidneys of Hmox1-/- mice.	Iron	26-30	heme oxygenase 1	Mus musculus	116-121
24350254-3	2013	Transferrin is essential for iron homeostasis because it transports iron from plasma into cells.	Iron	29-33	transferrin	Homo sapiens	0-11
23811556-11	2013	Thus, NO can carry Fe ions into m-aconitase via the guide of the tag of beta-CG addressed to the enzyme.	Iron	19-21	aconitase 2	Homo sapiens	32-43
24350254-3	2013	Transferrin is essential for iron homeostasis because it transports iron from plasma into cells.	Iron	68-72	transferrin	Homo sapiens	0-11
23057559-3	2013	These atypical microcytic anaemias can be classified as: (i) defects of intestinal iron absorption (ii) disorders of the transferrin receptor cycle that impair erythroblast iron uptake (iii) defects of mitochondrial iron utilization for haem or iron sulphur cluster synthesis and (iv) defects of iron recycling.	Iron	173-177	transferrin	Homo sapiens	121-132
24648899-0	2013	Excess iron undermined bone load-bearing capacity through tumor necrosis factor-alpha-dependent osteoclastic activation in mice.	Iron	7-11	tumor necrosis factor	Mus musculus	58-85
24648899-6	2013	Overall, the results suggested that iron overload resulted in a marked reduction of bone load-bearing capacity through a TNF-triggered osteoclast differentiation and resorption mechanism.	Iron	36-40	tumor necrosis factor	Mus musculus	121-124
23555091-3	2013	The diagnosis of iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism (serum ferritin and transferrin ) are affected by acute phase reaction.	Iron	17-21	transferrin	Homo sapiens	199-210
23291219-2	2013	Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type specific gene expression changes that result in increased erythropoietin (EPO) production in kidney and liver, in enhanced iron uptake and utilization and in adjustments of the bone marrow microenvironment that facilitate erythroid progenitor maturation and proliferation.	Iron	204-208	erythropoietin	Homo sapiens	155-158
23293203-2	2013	Iron overload was induced by intraperitoneal administration of iron-dextran into mice and resulting liver damage was manifested by significant rise in serum enzyme markers (ALT, AST, ALP and bilirubin) and reduction in liver antioxidants (SOD, CAT, GST and GSH).	Iron	0-4	transmembrane protease, serine 11d	Mus musculus	178-181
23293203-2	2013	Iron overload was induced by intraperitoneal administration of iron-dextran into mice and resulting liver damage was manifested by significant rise in serum enzyme markers (ALT, AST, ALP and bilirubin) and reduction in liver antioxidants (SOD, CAT, GST and GSH).	Iron	0-4	catalase	Mus musculus	244-247
23057559-3	2013	These atypical microcytic anaemias can be classified as: (i) defects of intestinal iron absorption (ii) disorders of the transferrin receptor cycle that impair erythroblast iron uptake (iii) defects of mitochondrial iron utilization for haem or iron sulphur cluster synthesis and (iv) defects of iron recycling.	Iron	173-177	transferrin	Homo sapiens	121-132
23057559-3	2013	These atypical microcytic anaemias can be classified as: (i) defects of intestinal iron absorption (ii) disorders of the transferrin receptor cycle that impair erythroblast iron uptake (iii) defects of mitochondrial iron utilization for haem or iron sulphur cluster synthesis and (iv) defects of iron recycling.	Iron	173-177	transferrin	Homo sapiens	121-132
23057559-3	2013	These atypical microcytic anaemias can be classified as: (i) defects of intestinal iron absorption (ii) disorders of the transferrin receptor cycle that impair erythroblast iron uptake (iii) defects of mitochondrial iron utilization for haem or iron sulphur cluster synthesis and (iv) defects of iron recycling.	Iron	173-177	transferrin	Homo sapiens	121-132
23634310-2	2013	Pantothenate-kinase-associated neurodegeneration (PKAN) is a rare genetic disease and a form of neurodegeneration with brain iron accumulation (NBIA).	Iron	125-129	pantothenate kinase 2	Homo sapiens	0-48
23087099-1	2013	AIMS: Haem oxygenase-1 (HO-1) is a haem-degrading enzyme that generates carbon monoxide, bilirubin, and iron ions.	Iron	104-108	heme oxygenase 1	Mus musculus	6-28
23634310-2	2013	Pantothenate-kinase-associated neurodegeneration (PKAN) is a rare genetic disease and a form of neurodegeneration with brain iron accumulation (NBIA).	Iron	125-129	pantothenate kinase 2	Homo sapiens	50-54
23856650-8	2013	Finally, intraperitoneal injection of the TNF-alpha antibody, infliximab, into iron-injured mice decreased TXAS expression and attenuated cardiac fibrosis.	Iron	79-83	tumor necrosis factor	Mus musculus	42-51
24112172-7	2013	The p53 expression was markedly increased in a concentration dependent manner in both iron treatment groups.	Iron	86-90	tumor protein p53	Homo sapiens	4-7
22710383-10	2013	Iron chelation with DFO markedly improved transplant success in a HIF-1alpha-dependent manner, thus demonstrating the mechanism of action.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
23856650-9	2013	CONCLUSIONS: TXA2 mediates iron-overload cardiomyopathy through the TNF-alpha-associated calcineurin-NFAT signaling pathway.	Iron	27-31	tumor necrosis factor	Mus musculus	68-77
24112172-8	2013	CONCLUSION: The soluble divalent iron and, to a greater degree trivalent iron, inhibited HASMC proliferation in a dosedependent manner, which may be attributed to reduction of PCNA expression and increase of p53 expression.	Iron	33-37	tumor protein p53	Homo sapiens	208-211
24112172-8	2013	CONCLUSION: The soluble divalent iron and, to a greater degree trivalent iron, inhibited HASMC proliferation in a dosedependent manner, which may be attributed to reduction of PCNA expression and increase of p53 expression.	Iron	73-77	tumor protein p53	Homo sapiens	208-211
23036229-4	2013	RESULTS: The change rates of hemoglobin (Hb) and transferrin saturation (TSAT: (serum iron/total iron binding capacity)) were identified as independent risk factors for changes in eGFR by multivariate regression analysis.	Iron	86-90	transferrin	Homo sapiens	49-60
23036229-4	2013	RESULTS: The change rates of hemoglobin (Hb) and transferrin saturation (TSAT: (serum iron/total iron binding capacity)) were identified as independent risk factors for changes in eGFR by multivariate regression analysis.	Iron	97-101	transferrin	Homo sapiens	49-60
23053489-4	2013	Previously reported mutations rib80, rib81, and hit1, which affect repression of riboflavin synthesis and iron accumulation by iron ions, caused similar drops in activities of the mentioned enzymes.	Iron	106-110	Hit1p	Saccharomyces cerevisiae S288C	48-52
23170793-4	2013	We have recently shown that trivalent iron (ferric ions) generates hydroxyl radicals, which subsequently convert FBG into abnormal fibrin clots in the form of DMDs.	Iron	38-42	fibrinogen beta chain	Homo sapiens	113-116
24133917-0	2013	Association of iron overload and oxidative stress with insulin resistance in transfusion-dependent beta-thalassemia major and beta-thalassemia/HbE patients.	Iron	15-19	insulin	Homo sapiens	55-62
24133917-10	2013	We observed a positive association between oxidative stress, iron overload and insulin resistance in these beta-TM patients.	Iron	61-65	insulin	Homo sapiens	79-86
23879590-3	2013	The inflammatory cytokine IL-6 is frequently up-regulated in Hodgkin"s lymphoma, and IL-6 levels are strongly associated with hepcidin, the main regulator of iron metabolism.	Iron	158-162	interleukin 6	Homo sapiens	85-89
23053489-4	2013	Previously reported mutations rib80, rib81, and hit1, which affect repression of riboflavin synthesis and iron accumulation by iron ions, caused similar drops in activities of the mentioned enzymes.	Iron	127-131	Hit1p	Saccharomyces cerevisiae S288C	48-52
23089144-4	2013	In the present work we investigated the association between four polymorphisms of the transferrin gene (rs8177178; rs8177179; rs4481157; rs1130459) and AMD in dependence on the transferrin protein and iron serum levels.	Iron	201-205	transferrin	Homo sapiens	86-97
23095116-9	2013	CONCLUSIONS: We for the first time documented high levels of serum s-HJV in CDA I patients, suggesting that it may contribute to iron loading pathology in CDA I and eventually in other anemias with ineffective erythropoiesis.	Iron	129-133	codanin 1	Homo sapiens	76-81
23092328-6	2013	HO-1 is a heme-degrading enzyme generating carbon monoxide, iron, and biliverdin/bilirubin, while BCRP is a heme efflux transporter.	Iron	60-64	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	98-102
23276910-2	2013	In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C&gt; T, rs1800566), NOS3 (894G&gt;T, rs1799983) and NFE2L2 (28312647A&gt;G, rs6726395).	Iron	145-149	NAD(P)H quinone dehydrogenase 1	Homo sapiens	170-174
21741805-0	2013	TNF-alpha-stimulated macrophages protect A549 lung cells against iron and oxidation.	Iron	65-69	tumor necrosis factor	Mus musculus	0-9
21741805-1	2013	Previously, we have shown that TNF-alpha protects iron-exposed J774 macrophages against iron-catalyzed oxidative lysosomal disruption and cell death by increasing reduced glutathione and H-ferritin in cells.	Iron	50-54	tumor necrosis factor	Mus musculus	31-40
21741805-1	2013	Previously, we have shown that TNF-alpha protects iron-exposed J774 macrophages against iron-catalyzed oxidative lysosomal disruption and cell death by increasing reduced glutathione and H-ferritin in cells.	Iron	88-92	tumor necrosis factor	Mus musculus	31-40
21741805-2	2013	Because J774 cells are able to harbor large amounts of iron, which is potentially harmful in a redox-active state, we hypothesized that TNF-alpha-stimulated J774 macrophages will prevent iron-driven oxidative killing of alveolar epithelial A549 cells in co-culture.	Iron	55-59	tumor necrosis factor	Mus musculus	136-145
21741805-2	2013	Because J774 cells are able to harbor large amounts of iron, which is potentially harmful in a redox-active state, we hypothesized that TNF-alpha-stimulated J774 macrophages will prevent iron-driven oxidative killing of alveolar epithelial A549 cells in co-culture.	Iron	187-191	tumor necrosis factor	Mus musculus	136-145
21741805-4	2013	When challenged by oxidants, however, reactive lysosomal iron in A549 cells promoted lysosomal disruption and cell death, particularly in the presence of TNF-alpha.	Iron	57-61	tumor necrosis factor	Mus musculus	154-163
21741805-6	2013	A549 cell death was particularly pronounced when iron and TNF-alpha were present in the conditioned medium during oxidant challenge; thus, iron-driven oxidative reactions in the culture medium were a much greater hazard to A549 cells than those taking place inside their lysosomes.	Iron	139-143	tumor necrosis factor	Mus musculus	58-67
21741805-8	2013	In co-cultures of TNF-alpha-stimulated lung cells, J774 macrophages sequestered iron inside their lysosomes and protected A549 cells from oxidative reactions and cell death.	Iron	80-84	tumor necrosis factor	Mus musculus	18-27
23276910-2	2013	In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C&gt; T, rs1800566), NOS3 (894G&gt;T, rs1799983) and NFE2L2 (28312647A&gt;G, rs6726395).	Iron	145-149	nitric oxide synthase 3	Homo sapiens	200-204
23276910-2	2013	In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C&gt; T, rs1800566), NOS3 (894G&gt;T, rs1799983) and NFE2L2 (28312647A&gt;G, rs6726395).	Iron	145-149	NFE2 like bZIP transcription factor 2	Homo sapiens	232-238
23581600-1	2013	Iron is an essential component in the structure of certain molecules such as hemoglobin (Hb), myoglobin, cytochrome C and some enzymes.	Iron	0-4	cytochrome c, somatic	Homo sapiens	105-117
23378755-0	2013	Deficiency of alpha-1-antitrypsin influences systemic iron homeostasis.	Iron	54-58	serpin family A member 1	Homo sapiens	14-33
23033317-1	2013	Mutations in the gene encoding the iron-sulfur-containing DNA helicase DDX11 (ChlR1) were recently identified as a cause of a new recessive cohesinopathy, Warsaw breakage syndrome (WABS), in a single patient with severe microcephaly, pre- and postnatal growth retardation, and abnormal skin pigmentation.	Iron	35-39	DEAD/H-box helicase 11	Homo sapiens	71-76
23033317-1	2013	Mutations in the gene encoding the iron-sulfur-containing DNA helicase DDX11 (ChlR1) were recently identified as a cause of a new recessive cohesinopathy, Warsaw breakage syndrome (WABS), in a single patient with severe microcephaly, pre- and postnatal growth retardation, and abnormal skin pigmentation.	Iron	35-39	DEAD/H-box helicase 11	Homo sapiens	78-83
23573308-1	2013	Ferritin L (FTL) and Ferritin H (FTH) subunits are responsible for intercellular iron storage.	Iron	81-85	ferritin light chain 1	Rattus norvegicus	0-10
23573308-1	2013	Ferritin L (FTL) and Ferritin H (FTH) subunits are responsible for intercellular iron storage.	Iron	81-85	ferritin light chain 1	Rattus norvegicus	12-15
23573308-1	2013	Ferritin L (FTL) and Ferritin H (FTH) subunits are responsible for intercellular iron storage.	Iron	81-85	ferritin heavy chain 1	Rattus norvegicus	21-31
23573308-1	2013	Ferritin L (FTL) and Ferritin H (FTH) subunits are responsible for intercellular iron storage.	Iron	81-85	ferritin heavy chain 1	Rattus norvegicus	33-36
24209433-0	2013	Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associated neurodegeneration (PLAN): review of two major neurodegeneration with brain iron accumulation (NBIA) phenotypes.	Iron	153-157	phospholipase A2 group VI	Homo sapiens	60-66
24319154-6	2013	Hepcidin excess resulting from genetic inactivation of a hepcidin inhibitor, the transmembrane protease serine 6 (TMPRSS6) leads to a form of iron deficiency refractory to oral iron.	Iron	142-146	transmembrane serine protease 6	Homo sapiens	81-112
24319154-6	2013	Hepcidin excess resulting from genetic inactivation of a hepcidin inhibitor, the transmembrane protease serine 6 (TMPRSS6) leads to a form of iron deficiency refractory to oral iron.	Iron	142-146	transmembrane serine protease 6	Homo sapiens	114-121
23378755-2	2013	We tested the postulate that alpha-1 antitrypsin (A1AT) polymorphism and the consequent deficiency of this antiprotease in humans are associated with a systemic disruption in iron homeostasis.	Iron	175-179	serpin family A member 1	Homo sapiens	29-48
23378755-2	2013	We tested the postulate that alpha-1 antitrypsin (A1AT) polymorphism and the consequent deficiency of this antiprotease in humans are associated with a systemic disruption in iron homeostasis.	Iron	175-179	serpin family A member 1	Homo sapiens	50-54
23378755-11	2013	Nonheme iron concentrations correlated (negatively) with levels of A1AT.	Iron	8-12	serpin family A member 1	Homo sapiens	67-71
23615377-4	2013	RESULTS: The women in the lowest iron tertile had higher high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-alpha (TNF-alpha) levels than the women in the top iron tertile (p&lt;0.01 or less for both).	Iron	33-37	tumor necrosis factor	Homo sapiens	105-132
23264147-3	2013	We also quantified iron overload by determining non-transferrin-bound iron (NTBI), which reflects iron overload more directly than ferritin, and compared the results with those of the ferritin assay.	Iron	70-74	transferrin	Homo sapiens	52-63
23264147-3	2013	We also quantified iron overload by determining non-transferrin-bound iron (NTBI), which reflects iron overload more directly than ferritin, and compared the results with those of the ferritin assay.	Iron	70-74	transferrin	Homo sapiens	52-63
23615377-4	2013	RESULTS: The women in the lowest iron tertile had higher high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-alpha (TNF-alpha) levels than the women in the top iron tertile (p&lt;0.01 or less for both).	Iron	33-37	tumor necrosis factor	Homo sapiens	134-143
23615377-8	2013	In the model to which the hemoglobin level was added as an independent variable, the levels of hemoglobin, hsCRP and TNF-alpha emerged as independent determinants of the serum iron level (R(2)= 0.192).	Iron	176-180	tumor necrosis factor	Homo sapiens	117-126
23615377-9	2013	CONCLUSIONS: The present study demonstrated that community-living elderly Japanese women with low serum iron levels have nontraditional risk factors for CVD, including low-grade inflammation and higher levels of serum adiponectin.	Iron	104-108	adiponectin, C1Q and collagen domain containing	Homo sapiens	218-229
24299624-0	2013	[Non-transferrin-bound iron: a promising biomarker in iron overload disorders].	Iron	23-27	transferrin	Homo sapiens	5-16
22446839-2	2013	Thus, we have recently synthesized multifunctional non-toxic, brain permeable iron chelating compounds, M30 and HLA20, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase (MAO)-B inhibitor, rasagiline and the antioxidant-iron chelating moiety of an 8-hydroxyquinoline derivative of the iron chelator, VK28.	Iron	78-82	monoamine oxidase B	Mus musculus	200-225
23173169-0	2013	Birth weight of Korean infants is affected by the interaction of maternal iron intake and GSTM1 polymorphism.	Iron	74-78	glutathione S-transferase mu 1	Homo sapiens	90-95
23173169-7	2013	Dietary iron consumption during pregnancy was positively associated with birth weight in pregnant women who were GSTM1-present after adjustment for the following covariates: maternal age, prepregnancy BMI, mother"s education level, log-transformed urinary cotinine level, infant gender, gestational age at term, log-transformed energy intake, parity, and the use of folic acid supplements (P &lt; 0.05).	Iron	8-12	glutathione S-transferase mu 1	Homo sapiens	113-118
23173169-8	2013	There were interactions between the GSTM1 genotype and iron intakes from animal foods (P &lt; 0.05), diet (P &lt; 0.05), and diet with supplements (P &lt; 0.05).	Iron	55-59	glutathione S-transferase mu 1	Homo sapiens	36-41
23173169-10	2013	This study demonstrates that increased iron consumption during pregnancy may improve infant birth weight for mothers who are GSTM1-present, but it might not be beneficial for mothers with the GSTM1-null genotype.	Iron	39-43	glutathione S-transferase mu 1	Homo sapiens	125-130
24299624-3	2013	Iron that is not bound to transferrin, haem or ferritin (non-transferrin-bound iron, NTBI) seems to play a key role in the pathophysiology of these disorders.	Iron	0-4	transferrin	Homo sapiens	61-72
24299624-3	2013	Iron that is not bound to transferrin, haem or ferritin (non-transferrin-bound iron, NTBI) seems to play a key role in the pathophysiology of these disorders.	Iron	79-83	transferrin	Homo sapiens	61-72
24378455-4	2013	The role of metals in neurodegenerative disorders and the correlation between iron metabolism and amyloid beta peptide are described.	Iron	78-82	amyloid beta precursor protein	Homo sapiens	98-110
23765353-3	2013	Dietary deficiencies of protein and specific micronutrients have long been associated with immune dysfunction and an adequate intake of iron, zinc, and vitamins A, D, E, B6 and B12 is particularly important in the maintenance of immune function.	Iron	136-140	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	177-180
23351410-4	2013	In this prospective study, the difference between dietary intakes of iron-deficient children (soluble transferrin receptor &gt;9.4 mg/L) and iron-sufficient children after 18 months on highly active antiretroviral therapy was examined.	Iron	69-73	transferrin	Homo sapiens	102-113
24308158-1	2013	Heme oxygenase-1 [HO-1, also called heat shot protein 32 (HSP32)] can specifically metabolize heme to carbon monoxide, biliverdin, and ferrous iron and plays an important role in the processes of anti-inflammation, tissue protection, and antioxidative stress reaction.	Iron	143-147	heme oxygenase 1	Mus musculus	0-16
24308158-1	2013	Heme oxygenase-1 [HO-1, also called heat shot protein 32 (HSP32)] can specifically metabolize heme to carbon monoxide, biliverdin, and ferrous iron and plays an important role in the processes of anti-inflammation, tissue protection, and antioxidative stress reaction.	Iron	143-147	heme oxygenase 1	Mus musculus	18-22
24308158-1	2013	Heme oxygenase-1 [HO-1, also called heat shot protein 32 (HSP32)] can specifically metabolize heme to carbon monoxide, biliverdin, and ferrous iron and plays an important role in the processes of anti-inflammation, tissue protection, and antioxidative stress reaction.	Iron	143-147	heme oxygenase 1	Mus musculus	36-56
24308158-1	2013	Heme oxygenase-1 [HO-1, also called heat shot protein 32 (HSP32)] can specifically metabolize heme to carbon monoxide, biliverdin, and ferrous iron and plays an important role in the processes of anti-inflammation, tissue protection, and antioxidative stress reaction.	Iron	143-147	heme oxygenase 1	Mus musculus	58-63
24349609-1	2013	Endogenous carbon monoxide (CO) is produced by heme oxygenase-1 (HO)-1 which mediates the degradation of heme into CO, iron, and biliverdin.	Iron	119-123	heme oxygenase 1	Mus musculus	47-63
23710288-4	2013	Subsequently raised neuronal iron levels can induce translation of the ferroportin assisting and copper binding amyloid precursor protein (APP); constitutive APP transmembrane passage lowers the copper pool which is important for many enzymes.	Iron	29-33	amyloid beta precursor protein	Homo sapiens	112-137
23766848-4	2013	Activated NRF2 bound the antioxidant response element (ARE) in promoters of several known and novel target genes involved in iron homeostasis and heme metabolism, including known targets FTL and FTH1, as well as novel binding in the globin locus control region.	Iron	125-129	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
23840921-8	2013	This effect suppressed the cellular heme-oxygenase-1 (HO-1) response and shifted macrophage iron homeostasis towards inappropriately high expression of the transferrin receptor with concurrent inhibition of ferroportin expression.	Iron	92-96	transferrin	Homo sapiens	156-167
23182313-1	2013	BACKGROUND: Mutations in the phospholipase A2 Group 6 (PLA2G6) gene have been identified in autosomal recessive neurodegenerative diseases classified as infantile neuroaxonal dystrophy and neurodegeneration with brain iron accumulation.	Iron	218-222	phospholipase A2 group VI	Homo sapiens	29-53
23182313-1	2013	BACKGROUND: Mutations in the phospholipase A2 Group 6 (PLA2G6) gene have been identified in autosomal recessive neurodegenerative diseases classified as infantile neuroaxonal dystrophy and neurodegeneration with brain iron accumulation.	Iron	218-222	phospholipase A2 group VI	Homo sapiens	55-61
23565256-5	2013	Consistently, incubation with iron-saturated transferrin induces Bmp6 mRNA expression in isolated hepatic stellate cells, but not in hepatocytes.	Iron	30-34	transferrin	Homo sapiens	45-56
23166355-9	2013	Heterologous expression of MEB1 and MEB2 in yeast (Saccharomyces cerevisiae) suppresses iron and manganese toxicity, suggesting that MEB1 and MEB2 are metal transporters.	Iron	88-92	vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	27-31
23166355-9	2013	Heterologous expression of MEB1 and MEB2 in yeast (Saccharomyces cerevisiae) suppresses iron and manganese toxicity, suggesting that MEB1 and MEB2 are metal transporters.	Iron	88-92	vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	133-137
23853552-0	2013	The effect of intermittent antenatal iron supplementation on maternal and infant outcomes in rural Viet Nam: a cluster randomised trial.	Iron	37-41	SH3 and cysteine rich domain 3	Homo sapiens	104-107
23565256-0	2013	Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway.	Iron	10-14	bone morphogenetic protein 6	Homo sapiens	31-35
23565256-5	2013	Consistently, incubation with iron-saturated transferrin induces Bmp6 mRNA expression in isolated hepatic stellate cells, but not in hepatocytes.	Iron	30-34	bone morphogenetic protein 6	Homo sapiens	65-69
23565256-2	2013	Bmp6 expression is upregulated by increased iron-levels in the liver.	Iron	44-48	bone morphogenetic protein 6	Homo sapiens	0-4
23565256-4	2013	Here we showed that induction of hepcidin expression in hepatocytes by dietary iron is associated with an elevation of Bmp6 mRNA in the non-parenchymal cells of the liver.	Iron	79-83	bone morphogenetic protein 6	Homo sapiens	119-123
23520538-2	2013	Cellular iron metabolism is coordinately controlled by the Iron Regulatory Proteins (IRP1 and IRP2), whose activity is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a current and persistent environmental contaminant.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	94-98
23520538-2	2013	Cellular iron metabolism is coordinately controlled by the Iron Regulatory Proteins (IRP1 and IRP2), whose activity is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a current and persistent environmental contaminant.	Iron	59-63	iron responsive element binding protein 2	Homo sapiens	94-98
23565256-6	2013	These observations suggest an important role of the non-parenchymal liver cells in regulating iron-homeostasis by acting as a source of Bmp6.	Iron	94-98	bone morphogenetic protein 6	Homo sapiens	136-140
23520547-5	2013	Additionally, treatment of curcumin caused the iron starvation induced expression of FET3, FRE1 genes.	Iron	47-51	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	91-95
23533643-5	2013	We show that HLH-29 regulates ftn-1 expression via promoter sequences upstream of the iron-dependent element that is recognized by the hypoxia inducible factor, HIF-1.	Iron	86-90	BHLH domain-containing protein	Caenorhabditis elegans	13-19
23533643-5	2013	We show that HLH-29 regulates ftn-1 expression via promoter sequences upstream of the iron-dependent element that is recognized by the hypoxia inducible factor, HIF-1.	Iron	86-90	Hypoxia-inducible factor 1	Caenorhabditis elegans	161-166
23533643-6	2013	Additionally, hlh-29 mutants are more resistant to peroxide stress than wild-type animals and ftn-1(RNAi) animals, even in the presence of excess iron.	Iron	146-150	BHLH domain-containing protein	Caenorhabditis elegans	14-20
23423156-5	2013	These SPION-micelles selectively release iron ions inside cancer cells, which interact with hydrogen peroxide (H(2)O(2)) generated from beta-lap in a tumor-specific, NQO1-dependent manner.	Iron	41-45	NAD(P)H quinone dehydrogenase 1	Homo sapiens	166-170
23505486-11	2013	Specific inhibition of recombinant P. vivax DOHH is possible by complexing the ferrous iron with zileuton, an inhibitor of mammalian 5-lipoxygenase (5-LOX).	Iron	79-91	arachidonate 5-lipoxygenase	Homo sapiens	133-147
23505486-11	2013	Specific inhibition of recombinant P. vivax DOHH is possible by complexing the ferrous iron with zileuton, an inhibitor of mammalian 5-lipoxygenase (5-LOX).	Iron	79-91	arachidonate 5-lipoxygenase	Homo sapiens	149-154
23505486-12	2013	Ferrous iron in the active site of 5-LOX is coordinated by three conserved histidines and the carboxylate of isoleucine(673).	Iron	0-12	arachidonate 5-lipoxygenase	Homo sapiens	35-40
23318681-4	2013	Therefore, pure and Fe-bearing MgSiO(3) PPv should demonstrate similar LPO patterns with a strong signature of the [100](001) slip system.	Iron	20-22	lactoperoxidase	Homo sapiens	71-74
23424997-0	2013	Relationship between iron metabolism, oxidative stress, and insulin resistance in patients with systemic lupus erythematosus.	Iron	21-25	insulin	Homo sapiens	60-67
23451225-2	2013	We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively.	Iron	186-190	interleukin 1 beta	Homo sapiens	88-96
23451225-2	2013	We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively.	Iron	186-190	tumor necrosis factor	Homo sapiens	104-113
23451225-2	2013	We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively.	Iron	306-310	interleukin 1 beta	Homo sapiens	88-96
23451225-2	2013	We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively.	Iron	306-310	tumor necrosis factor	Homo sapiens	104-113
23853581-2	2013	Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 production regulates expression of iron chelators, heme and siderophore binding proteins and hepcidin in infected mice.	Iron	172-176	interleukin 6	Mus musculus	132-136
23400918-6	2013	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells which express CYP2E1 (E47 cells) but not control C34HepG2 cells which do not express CYP2E1.Toxicity was associated with enhanced oxidant stress and could be prevented by antioxidants and potentiated if glutathione (GSH) was removed.	Iron	41-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	90-96
23400918-6	2013	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells which express CYP2E1 (E47 cells) but not control C34HepG2 cells which do not express CYP2E1.Toxicity was associated with enhanced oxidant stress and could be prevented by antioxidants and potentiated if glutathione (GSH) was removed.	Iron	41-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	161-167
23200187-5	2013	Finally, PHD activation has been shown to involve the iron chaperoning function of poly(rC) binding protein (PCBP)1 and the (R)-enantiomer of 2-hydroxyglutarate (2-HG).	Iron	54-58	poly(rC) binding protein 1	Homo sapiens	109-115
23375326-0	2013	Iron metabolism, hepcidin, and anemia in orthotopic heart transplantation recipients treated with mammalian target of rapamycin.	Iron	0-4	mechanistic target of rapamycin kinase	Homo sapiens	98-127
23548999-10	2013	Nearly 20% of those who replied correctly employed transferrin saturation levels as a marker to guide iron supplementation.	Iron	102-106	transferrin	Homo sapiens	51-62
24592737-7	2013	Thus, the level of transferrin (Tf, which is responsible for the transport of iron ions, is reduced in 2.5 to 3 times (from 5.0 to 1.6 mg/ml) in the blood plasma, whereas the Tf level in the ascitic fluid increased from 1.5 to 2.7 mg/ml.	Iron	78-82	transferrin	Rattus norvegicus	19-30
27877515-8	2012	On the other hand, the spin fluctuations differ for alkali-metal-doped Ax Fe2-y Se2 and FeSe or other Fe-based superconductors in their wave vector and strength in the low-energy part, most likely because of the different Fermi surfaces.	Iron	74-76	fucosyltransferase 2	Homo sapiens	80-83
23150669-2	2012	A dedicated cytosolic Fe-S cluster assembly (CIA) system is required to assemble Fe-S clusters into cytosolic and nuclear proteins.	Iron	22-26	nuclear receptor coactivator 5	Homo sapiens	45-48
23150669-2	2012	A dedicated cytosolic Fe-S cluster assembly (CIA) system is required to assemble Fe-S clusters into cytosolic and nuclear proteins.	Iron	81-85	nuclear receptor coactivator 5	Homo sapiens	45-48
23245266-6	2012	Furthermore, CD4+ T-lymphocyte cell count had a positive correlation with levels of vitamin C (r = 0.497, P &lt; 0.001), zinc (r = 0.737, P &lt; 0.001), selenium (r = 0.639, P &lt; 0.001) and a negative correlation with serum iron levels (r = -0.572, P &lt; 0.001).	Iron	226-230	CD4 molecule	Homo sapiens	13-16
23245266-7	2012	CONCLUSION: It could be inferred that derangement in iron metabolism, in addition to oxidative stress, might have contributed to the depletion of CD4+ T cell population in our subjects and this may result in poor prognosis of the disease.	Iron	53-57	CD4 molecule	Homo sapiens	146-149
23169664-4	2012	Studies using the muscle creatine kinase (MCK) conditional frataxin knockout mouse that mirrors the disease have demonstrated frataxin deletion alters cardiac Fe metabolism.	Iron	159-161	creatine kinase, muscle	Mus musculus	18-40
23169664-4	2012	Studies using the muscle creatine kinase (MCK) conditional frataxin knockout mouse that mirrors the disease have demonstrated frataxin deletion alters cardiac Fe metabolism.	Iron	159-161	creatine kinase, muscle	Mus musculus	42-45
23169664-6	2012	Considering Fe deficiency can induce apoptosis and cell death, we examined the effect of dietary Fe supplementation, which led to body Fe loading and limited the cardiac hypertrophy in MCK mutants.	Iron	97-99	creatine kinase, muscle	Mus musculus	185-188
27877515-9	2012	The resonance mode with different wave vector suggests that Ax Fe2-y Se2 has an exceptional superconducting symmetry among Fe-based superconductors.	Iron	63-65	fucosyltransferase 2	Homo sapiens	69-72
23231908-0	2012	Resonance micro-Raman investigations of the rat medial preoptic nucleus: effects of a low-iron diet on the neuroglobin content.	Iron	90-94	neuroglobin	Rattus norvegicus	107-118
24175256-2	2012	This response proves advantageous in the short-term to restrain iron availability to pathogens, but ultimately leads to severe anemia, and impairs the response to erythropoietin (Epo) and iron.	Iron	64-68	erythropoietin	Homo sapiens	163-177
24175256-2	2012	This response proves advantageous in the short-term to restrain iron availability to pathogens, but ultimately leads to severe anemia, and impairs the response to erythropoietin (Epo) and iron.	Iron	64-68	erythropoietin	Homo sapiens	179-182
23001667-5	2012	Iron-limited cultures also exhibit decreased cytochrome c-to-total protein ratios and cell-specific sulfate reduction rates (csSRR), implying changes in the electron transport chain that couples carbon and sulfur metabolisms.	Iron	0-4	cytochrome c, somatic	Homo sapiens	45-57
23231908-9	2012	The different spectra showed a decrease of the Ngb and lipid content for the animals on the low-iron diet.	Iron	96-100	neuroglobin	Rattus norvegicus	47-50
22982814-2	2012	Soybean lipoxygenase-1 (sLOX-1) contains non-heme iron and oxidizes 18:2n-6 with a large deuterium kinetic isotope effect (D-KIE).	Iron	50-54	seed linoleate 13S-lipoxygenase-1	Glycine max	8-22
23540189-3	2012	To evaluate the effect of short-term administration of recombinant human erythropoietin (rHuEPO) with iron and folic acid in very low birth weight (VLBW) neonates in the prevention of anaemia of prematurity.	Iron	102-106	erythropoietin	Homo sapiens	73-87
23010583-8	2012	Iron-induced oxidative stress promoted an increased localization of PLD1 in membrane rafts, whereas PLD2 was excluded from these domains and appeared to be involved in glutamate transporter function.	Iron	0-4	phospholipase D1	Rattus norvegicus	68-72
22910858-12	2012	Therefore, blocking MCU may be an effective therapy to prevent iron-overload induced cardiac mitochondrial dysfunction in patients with thalassemia.	Iron	63-67	mitochondrial calcium uniporter	Homo sapiens	20-23
23065424-6	2012	The maximum effect on Fe uptake was observed in cells incubated with 30 ng/ml IL6 (p &lt; 0.01) and 500 ng/ml LPS (p &lt; 0.05).	Iron	22-24	interleukin 6	Homo sapiens	78-81
22885719-2	2012	The rs855791 polymorphism, encoding for the p.A736V variant of TMPRSS6 regulating hepcidin, influences iron status in the population.	Iron	103-107	transmembrane serine protease 6	Homo sapiens	63-70
22950866-14	2012	The iron nanoparticles and IMR provides a novel method to measure plasma Abeta and could serve as an important clinical tool for the diagnosis of neurodegenerative diseases.	Iron	4-8	amyloid beta precursor protein	Homo sapiens	73-78
23114598-1	2012	Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis in kidney and liver.	Iron	0-4	erythropoietin	Homo sapiens	96-110
23114598-1	2012	Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis in kidney and liver.	Iron	0-4	erythropoietin	Homo sapiens	112-115
22819647-3	2012	Coordination of redox active metal ions such as copper or iron to the amyloid-beta (Abeta) peptide has been linked to deleterious processes encountered in the etiology of Alzheimer disease (AD), such as Abeta aggregation and reactive oxygen species (ROS) production.	Iron	58-62	amyloid beta precursor protein	Homo sapiens	70-82
22819647-3	2012	Coordination of redox active metal ions such as copper or iron to the amyloid-beta (Abeta) peptide has been linked to deleterious processes encountered in the etiology of Alzheimer disease (AD), such as Abeta aggregation and reactive oxygen species (ROS) production.	Iron	58-62	amyloid beta precursor protein	Homo sapiens	84-89
22961397-2	2012	The ferroxidase activity of hephaestin is thought to play an important role during iron export from intestinal enterocytes and the subsequent iron loading of the blood protein transferrin, which delivers iron to the tissues.	Iron	142-146	transferrin	Homo sapiens	176-187
22961397-2	2012	The ferroxidase activity of hephaestin is thought to play an important role during iron export from intestinal enterocytes and the subsequent iron loading of the blood protein transferrin, which delivers iron to the tissues.	Iron	142-146	transferrin	Homo sapiens	176-187
23064962-9	2012	The results suggested that CD61 regulates the expressions of Slc11a2 and Slc40a1, both of which are involved in iron transportation in epithelial tissues.	Iron	112-116	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	73-80
23045394-4	2012	Aft1p dissociates from its target promoters under iron-replete conditions due to an interaction between Aft1p and the monothiol glutaredoxin Grx3p or Grx4p (Grx3/4p).	Iron	50-54	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	150-155
22560353-1	2012	The mechanism by which hepcidin controls cellular iron release protein ferroportin 1 (Fpn1) in macrophages has been well established.	Iron	50-54	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	71-84
22560353-1	2012	The mechanism by which hepcidin controls cellular iron release protein ferroportin 1 (Fpn1) in macrophages has been well established.	Iron	50-54	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	86-90
23045394-7	2012	These results suggest that iron binding to Grx3p (and presumably Grx4p) is a prerequisite for the suppression of Aft1p.	Iron	27-31	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	65-70
21968932-9	2012	LYRM4 is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters, essential cofactors in multiple processes, including oxidative phosphorylation.	Iron	75-79	LYR motif containing 4	Homo sapiens	0-5
23151869-0	2012	Reference measurement procedures for the iron saturation in human transferrin based on IDMS and Raman scattering.	Iron	41-45	transferrin	Homo sapiens	66-77
23151869-1	2012	Two reference measurement procedures are presented here that allow the determination of the iron saturation in human transferrin, based on different molecular properties.	Iron	92-96	transferrin	Homo sapiens	117-128
23151869-3	2012	Up to now, the iron saturation has only been deduced indirectly from the amount-of-substance ratio of serum iron to transferrin in serum.	Iron	15-19	transferrin	Homo sapiens	116-127
23151869-7	2012	Based on the results, a straightforward Raman procedure was evolved, which allows the determination of the iron saturation in transferrin with an associated relative expanded uncertainty of 7%.	Iron	107-111	transferrin	Homo sapiens	126-137
23192001-2	2012	Transferrin receptor (TfR) is an endocytic receptor and identified as tumor relative specific due to its overexpression on most tumor cells or tissues, and TfR binds and intakes of transferrin-iron complex.	Iron	193-197	transferrin	Homo sapiens	181-192
22038683-6	2012	Some of the risk factors for RLS include female gender, pregnancy, low iron levels, lower socioeconomic status, poor health, elderly age, comorbidity with Parkinson"s disease, positive family history of RLS, and comorbidity with psychiatric disorders.	Iron	71-75	RLS1	Homo sapiens	29-32
23585819-0	2012	Effect of iron chelators on methemoglobin and thrombin preconditioning.	Iron	10-14	coagulation factor II, thrombin	Homo sapiens	46-54
23585819-7	2012	However, if cultures were pretreated with metHb or thrombin plus deferoxamine or 2,2"-bipyridyl, ferritin induction was prevented and cellular redox-active iron increased with hemin treatment.	Iron	156-160	coagulation factor II, thrombin	Homo sapiens	51-59
23194296-0	2012	Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.).	Iron	75-79	transferrin	Homo sapiens	116-127
23194296-1	2012	BACKGROUND: Transferrin (TF) plays a critical physiological role in cellular iron delivery via the transferrin receptor (TFR)-mediated endocytosis pathway in nearly all eukaryotic organisms.	Iron	77-81	transferrin	Homo sapiens	12-23
23194296-1	2012	BACKGROUND: Transferrin (TF) plays a critical physiological role in cellular iron delivery via the transferrin receptor (TFR)-mediated endocytosis pathway in nearly all eukaryotic organisms.	Iron	77-81	transferrin	Homo sapiens	25-27
23194296-2	2012	Human serum TF (hTF) is extensively used as an iron-delivery vehicle in various mammalian cell cultures for production of therapeutic proteins, and is also being explored for use as a drug carrier to treat a number of diseases by employing its unique TFR-mediated endocytosis pathway.	Iron	47-51	transferrin	Homo sapiens	12-14
23174983-2	2012	The catalytic properties of cytochrome P-450 and soluble methane monooxygenase enzymes are associated with oxo species on mononuclear iron haem and diiron non-haem platforms, respectively.	Iron	134-138	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-44
22670665-1	2012	Heme oxygenase-1 (HO-1) is an antioxidant, antiapoptotic and cytoprotective enzyme, catalysing the degradation of heme to carbon monoxide, biliverdin and ferrous iron.	Iron	162-166	heme oxygenase 1	Mus musculus	0-16
22670665-1	2012	Heme oxygenase-1 (HO-1) is an antioxidant, antiapoptotic and cytoprotective enzyme, catalysing the degradation of heme to carbon monoxide, biliverdin and ferrous iron.	Iron	162-166	heme oxygenase 1	Mus musculus	18-22
23585710-0	2012	Cafestol to Tricalysiolide B and Oxidized Analogues: Biosynthetic and Derivatization Studies Using Non-heme Iron Catalyst Fe(PDP).	Iron	108-112	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	125-128
23585710-0	2012	Cafestol to Tricalysiolide B and Oxidized Analogues: Biosynthetic and Derivatization Studies Using Non-heme Iron Catalyst Fe(PDP).	Iron	122-124	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	125-128
23585710-2	2012	Herein we validate the use of our non-heme iron complex, Fe(PDP), as an oxidative tailoring enzyme mimic to test the proposal that this class of natural products derives from cafestol via cytochrome P-450-mediated furan oxidation.	Iron	43-47	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	60-63
23585710-2	2012	Herein we validate the use of our non-heme iron complex, Fe(PDP), as an oxidative tailoring enzyme mimic to test the proposal that this class of natural products derives from cafestol via cytochrome P-450-mediated furan oxidation.	Iron	43-47	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	188-204
23585710-2	2012	Herein we validate the use of our non-heme iron complex, Fe(PDP), as an oxidative tailoring enzyme mimic to test the proposal that this class of natural products derives from cafestol via cytochrome P-450-mediated furan oxidation.	Iron	57-59	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	60-63
23585710-2	2012	Herein we validate the use of our non-heme iron complex, Fe(PDP), as an oxidative tailoring enzyme mimic to test the proposal that this class of natural products derives from cafestol via cytochrome P-450-mediated furan oxidation.	Iron	57-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	188-204
22836384-8	2012	The typical changes of iron metabolism and hepcidin synthesis in RA are induced by proinflammatory cytokines, primarily interleukin-6.	Iron	23-27	interleukin 6	Homo sapiens	120-133
23026080-5	2012	Matriptase-2 represents an important regulatory protease in iron homeostasis by down-regulation of the hepcidin expression.	Iron	60-64	transmembrane serine protease 6	Homo sapiens	0-12
23102618-0	2012	mTOR regulates cellular iron homeostasis through tristetraprolin.	Iron	24-28	mechanistic target of rapamycin kinase	Homo sapiens	0-4
23102618-3	2012	Here we report that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating transferrin receptor 1 (TfR1) stability and altering cellular iron flux.	Iron	71-75	mechanistic target of rapamycin kinase	Homo sapiens	24-53
23102618-3	2012	Here we report that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating transferrin receptor 1 (TfR1) stability and altering cellular iron flux.	Iron	71-75	mechanistic target of rapamycin kinase	Homo sapiens	55-59
23102618-3	2012	Here we report that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating transferrin receptor 1 (TfR1) stability and altering cellular iron flux.	Iron	164-168	mechanistic target of rapamycin kinase	Homo sapiens	24-53
23102618-3	2012	Here we report that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating transferrin receptor 1 (TfR1) stability and altering cellular iron flux.	Iron	164-168	mechanistic target of rapamycin kinase	Homo sapiens	55-59
22804687-4	2012	Despite their very similar domain organisation, STEAP3 seems to act as a potent metalloreductase essential for physiological iron uptake and turnover, while in particular STEAP4 appears to be rather involved in responses to nutrients and inflammatory stress, fatty acid and glucose metabolism.	Iron	125-129	STEAP3 metalloreductase	Homo sapiens	48-54
23035118-4	2012	SIGNIFICANCE: Oxidative stress negatively influences the mammalian Fe-S cluster assembly machinery by destabilization of ISCU.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	121-125
23035118-5	2012	Iron-sulfur (Fe-S) cluster cofactors are formed on the scaffold protein ISCU.	Iron	13-17	iron-sulfur cluster assembly enzyme	Homo sapiens	72-76
23076332-2	2012	To survive within the host and establish an infection, GAS requires essential nutrients, including iron.	Iron	99-103	PAXIP1 associated glutamate rich protein 1	Homo sapiens	55-58
23076332-8	2012	Furthermore, Shr-mediated iron uptake contributes to GAS growth in human blood, and is required for full virulence of serotype M1T1 GAS in mouse models of invasive disease.	Iron	26-30	PAXIP1 associated glutamate rich protein 1	Homo sapiens	53-56
23076332-8	2012	Furthermore, Shr-mediated iron uptake contributes to GAS growth in human blood, and is required for full virulence of serotype M1T1 GAS in mouse models of invasive disease.	Iron	26-30	PAXIP1 associated glutamate rich protein 1	Homo sapiens	132-135
23140174-4	2012	We also found that inhibition of CDK2 by iron chelators leads to the inhibition of CDK9 activity, suggesting a functional link between CDK2 and CDK9.	Iron	41-45	cyclin dependent kinase 9	Homo sapiens	83-87
23140174-4	2012	We also found that inhibition of CDK2 by iron chelators leads to the inhibition of CDK9 activity, suggesting a functional link between CDK2 and CDK9.	Iron	41-45	cyclin dependent kinase 9	Homo sapiens	144-148
22898098-4	2012	When iron is also present, CMPF and A-II induce the Fenton reaction, resulting in a further increase in ROS production.	Iron	5-9	angiotensinogen	Homo sapiens	36-40
22948448-9	2012	MAIN OUTCOME MEASURES: Iron deficiency anemia and ID were determined by levels of hemoglobin, serum iron, total iron-binding capacity, transferrin saturation, and serum ferritin.	Iron	23-27	transferrin	Homo sapiens	135-146
22591187-8	2012	HNF-1beta increases the survival of endometriotic cells under iron-induced oxidative stress conditions possibly through the activation of forkhead box (FOX) transcription factors and/or endometriosis-specific expression of microRNAs.	Iron	62-66	HNF1 homeobox B	Homo sapiens	0-9
22896728-8	2012	Molecular docking simulations showed that the 5" position of the pyrimidine moiety of PF-00734200 can access the heme iron-oxo of both CYP3A4 and CYP2D6 in an energetically favored orientation.	Iron	118-122	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	135-141
22896728-8	2012	Molecular docking simulations showed that the 5" position of the pyrimidine moiety of PF-00734200 can access the heme iron-oxo of both CYP3A4 and CYP2D6 in an energetically favored orientation.	Iron	118-122	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	146-152
22991317-0	2012	Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients.	Iron	13-17	pantothenate kinase 2	Homo sapiens	73-77
22991317-4	2012	According to this model, we estimated the iron content in PKAN patients as 391 microg/ml of antiferromagnetic iron (ferritin) and 1.1 microg/ml of ferrimagnetic iron, compared with 178 microg/ml of iron in ferritin found in controls.	Iron	42-46	pantothenate kinase 2	Homo sapiens	58-62
22991317-4	2012	According to this model, we estimated the iron content in PKAN patients as 391 microg/ml of antiferromagnetic iron (ferritin) and 1.1 microg/ml of ferrimagnetic iron, compared with 178 microg/ml of iron in ferritin found in controls.	Iron	110-114	pantothenate kinase 2	Homo sapiens	58-62
22991317-4	2012	According to this model, we estimated the iron content in PKAN patients as 391 microg/ml of antiferromagnetic iron (ferritin) and 1.1 microg/ml of ferrimagnetic iron, compared with 178 microg/ml of iron in ferritin found in controls.	Iron	110-114	pantothenate kinase 2	Homo sapiens	58-62
22991317-4	2012	According to this model, we estimated the iron content in PKAN patients as 391 microg/ml of antiferromagnetic iron (ferritin) and 1.1 microg/ml of ferrimagnetic iron, compared with 178 microg/ml of iron in ferritin found in controls.	Iron	110-114	pantothenate kinase 2	Homo sapiens	58-62
22591204-0	2012	Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice.	Iron	60-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
22591204-4	2012	Accordingly, it was examined how Nrf2 regulates lipid-related and iron-regulatory genes after feeding a high-fat diet (HFD) with iron.	Iron	66-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
22591204-4	2012	Accordingly, it was examined how Nrf2 regulates lipid-related and iron-regulatory genes after feeding a high-fat diet (HFD) with iron.	Iron	129-133	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
22591204-8	2012	Hepatic malondialdehyde was higher and hepatic iron levels tended to be higher in Nrf2-null mice than wild-type counterparts while on a HFD.	Iron	47-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
22591204-9	2012	The HFD with iron synergistically induced mRNA expression of Pparalpha targets, including Acox and Cpt1 in wild-type mice, yet the induction was diminished in Nrf2-null mice.	Iron	13-17	peroxisome proliferator activated receptor alpha	Mus musculus	61-70
22591204-9	2012	The HFD with iron synergistically induced mRNA expression of Pparalpha targets, including Acox and Cpt1 in wild-type mice, yet the induction was diminished in Nrf2-null mice.	Iron	13-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	159-163
22591204-10	2012	Hepatic hepcidin and ferroportin 1 mRNA expression were increased in wild-type mice after feeding a HFD with iron, but were unchanged in any group of Nrf2-null mice.	Iron	109-113	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	21-34
22591204-11	2012	CONCLUSIONS: Nrf2 deletion dysregulates hepatic mRNA expression of beta-oxidation enzymes and iron-related genes, possibly causing a trend for increased hepatic triglyceride and iron concentrations.	Iron	94-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
22591204-11	2012	CONCLUSIONS: Nrf2 deletion dysregulates hepatic mRNA expression of beta-oxidation enzymes and iron-related genes, possibly causing a trend for increased hepatic triglyceride and iron concentrations.	Iron	178-182	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
22896672-8	2012	This study presents a novel finding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confirms prior reported associations, including that with vitamin C.	Iron	60-64	paraoxonase 1	Homo sapiens	92-96
22990466-8	2012	We therefore conclude that DCYTB is the primary iron-regulated duodenal ferric reductase in the gut and that Dcytb is necessary for optimal iron metabolism.	Iron	48-52	cytochrome b reductase 1	Mus musculus	27-32
22922699-9	2012	Consistent with these findings, iron restriction suppressed increased gene expression of collagen type III, transforming growth factor-beta, CD68, and tumor necrosis factor-alpha in the CKD kidney.	Iron	32-36	tumor necrosis factor	Rattus norvegicus	151-178
22922699-10	2012	Importantly, increased expression of nuclear mineralocorticoid receptor and SGK1, a key downstream effector of mineralocorticoid receptor signaling, in the CKD kidney was markedly attenuated by iron restriction.	Iron	194-198	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	45-71
22922699-10	2012	Importantly, increased expression of nuclear mineralocorticoid receptor and SGK1, a key downstream effector of mineralocorticoid receptor signaling, in the CKD kidney was markedly attenuated by iron restriction.	Iron	194-198	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	111-137
22922699-13	2012	CONCLUSION: Taken together, these data uncover a novel effect of iron restriction on renal damage and hypertension through the inhibition of renal mineralocorticoid receptor signaling.	Iron	65-69	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	147-173
22939643-10	2012	The mean change in hematocrit level as an indicator of the change in red cell mass was statistically significantly different (P = .01) for the subjects who received preoperative administration of EPO with iron supplementation compared with those who did not receive EPO plus iron.	Iron	205-209	erythropoietin	Homo sapiens	196-199
22939643-11	2012	The administration of EPO plus iron was protective: the decrease in hematocrit level after surgery was smaller for subjects in the EPO group even after we controlled for age, gender, preoperative hematocrit level, length of surgery, blood loss, and crystalloid (fluid replacement) volume.	Iron	31-35	erythropoietin	Homo sapiens	131-134
22990466-8	2012	We therefore conclude that DCYTB is the primary iron-regulated duodenal ferric reductase in the gut and that Dcytb is necessary for optimal iron metabolism.	Iron	140-144	cytochrome b reductase 1	Mus musculus	109-114
22939643-12	2012	CONCLUSIONS: A single preoperative dose of erythropoietin with iron supplementation resulted in a smaller decrease, on average, in postoperative red cell mass as indicated by hematocrit value in patients with complicated orthognathic surgery procedures.	Iron	63-67	erythropoietin	Homo sapiens	43-57
22990466-1	2012	Duodenal cytochrome b (Dcytb, Cybrd1) is a ferric reductase localized in the duodenum that is highly upregulated in circumstances of increased iron absorption.	Iron	143-147	cytochrome b reductase 1	Mus musculus	0-21
23387277-7	2012	This iron pool content in the interval from the 1st to the 6st day was more than 2 mg/l and significantly higher than the transferrin iron level.	Iron	134-138	transferrin	Rattus norvegicus	122-133
22990466-1	2012	Duodenal cytochrome b (Dcytb, Cybrd1) is a ferric reductase localized in the duodenum that is highly upregulated in circumstances of increased iron absorption.	Iron	143-147	cytochrome b reductase 1	Mus musculus	23-28
22990466-1	2012	Duodenal cytochrome b (Dcytb, Cybrd1) is a ferric reductase localized in the duodenum that is highly upregulated in circumstances of increased iron absorption.	Iron	143-147	cytochrome b reductase 1	Mus musculus	30-36
23588470-1	2012	INTRODUCTION: Transferrin (Tf) exerts a crucial function in the maintenance of systemic iron homeostasis.	Iron	88-92	transferrin	Homo sapiens	14-25
23588470-1	2012	INTRODUCTION: Transferrin (Tf) exerts a crucial function in the maintenance of systemic iron homeostasis.	Iron	88-92	transferrin	Homo sapiens	27-29
23215202-2	2012	Here, around a new unified first-principles determined Hugoniot curve of iron from the normal condensed condition up to 1 Gbar, the novel structures characterized by the ionic clusters with electron bubbles are found using quantum Langevin molecular dynamics.	Iron	73-77	adaptor related protein complex 1 associated regulatory protein	Homo sapiens	122-126
23066374-2	2012	While iron, genetics, and central nervous system dopamine have been shown to play major roles in RLS unrelated to pregnancy, the etiology and treatment of RLS during pregnancy have not been adequately delineated.	Iron	6-10	RLS1	Homo sapiens	97-100
23066374-3	2012	We describe a novel approach where a 23-year-old female was given intravenous iron prior to pregnancy, with complete remission of RLS symptoms until five months postpartum.	Iron	78-82	RLS1	Homo sapiens	130-133
23066366-1	2012	STUDY OBJECTIVE: To test the hypothesis that low iron availability, measured as transferrin saturation, is associated with low nocturnal hemoglobin oxygen saturation (SpO(2)) in children with homozygous sickle cell anemia (SCA; hemoglobin SS).	Iron	49-53	transferrin	Homo sapiens	80-91
22923613-1	2012	Human heme oxygenases 1 and 2 (HO-1 and HO-2) degrade heme in the presence of oxygen and NADPH-cytochrome P450 reductase, producing ferrous iron, CO, and biliverdin.	Iron	140-144	cytochrome p450 oxidoreductase	Homo sapiens	89-120
23066366-6	2012	CONCLUSIONS: Contrary to our hypothesis, higher iron availability, assessed by transferrin saturation, is associated with nocturnal chronic and intermittent hemoglobin oxygen desaturation in SCA.	Iron	48-52	transferrin	Homo sapiens	79-90
22915593-2	2012	Using a genetic screen to identify genes involved in Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondrial chaperone involved in iron-sulfur cluster synthesis, prevented expression of Yap5 target genes.	Iron	58-62	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	105-109
22915593-2	2012	Using a genetic screen to identify genes involved in Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondrial chaperone involved in iron-sulfur cluster synthesis, prevented expression of Yap5 target genes.	Iron	163-167	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	105-109
22893705-1	2012	Hemojuvelin (HJV) and matriptase-2 (MT2) are co-expressed in hepatocytes, and both are essential for systemic iron homeostasis.	Iron	110-114	transmembrane serine protease 6	Homo sapiens	22-34
22893705-1	2012	Hemojuvelin (HJV) and matriptase-2 (MT2) are co-expressed in hepatocytes, and both are essential for systemic iron homeostasis.	Iron	110-114	transmembrane serine protease 6	Homo sapiens	36-39
22426798-7	2012	mRNA relative abundance of nuclear factor kappa-light-chain-enhancer of activated B cells was elevated in OBDM with anemia, and mRNA expression of interleukin-6 and toll-like receptor (TLR) 2 was increased in OBDM group in basal high Fe and high glucose concentrations.	Iron	234-236	interleukin 6	Homo sapiens	147-160
23000401-3	2012	Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1beta induces divalent metal transporter 1 (DMT1) expression correlating with increased beta cell iron content and ROS production.	Iron	198-202	interleukin 1 beta	Mus musculus	97-105
23230575-2	2012	Thus, assessing iron status is integral to both iron and anemia management in CKD patients, as iron is essential for Hb formation (as is erythropoietin).	Iron	16-20	erythropoietin	Homo sapiens	137-151
22896707-6	2012	Furthermore we found two essential molecules for iron homeostasis, iron-sulfur cluster scaffold protein (ISCU) and transferrin receptor 1 (TfR), are a direct target of miR-210.	Iron	49-53	iron-sulfur cluster assembly enzyme	Homo sapiens	105-109
22998881-5	2012	In the cross-sectional study, infused iron, hepcidin, and C-reactive protein values correlated with hepatic iron stores in both univariate analysis (P&lt;.05, Spearman test) and binary logistic regression (P &lt;.05).	Iron	108-112	C-reactive protein	Homo sapiens	58-76
22909970-10	2012	Thus, suppression of autophagy by E 2 via ERalpha contributes to less severity of iron-induced brain injury in females than in male.	Iron	82-86	estrogen receptor 1	Homo sapiens	42-49
22840541-3	2012	When the iron powder was added to an aqueous ClO(4)(-) solution (104 muM) and the mixture was heated at 150 C, ClO(4)(-) concentration fell below 0.58 muM (58 mug L(-1), detection limit of ion chromatography) in 1 h, and Cl(-) was formed with the yield of 85% after 6 h. The decomposition was accompanied by transformation of the zerovalent iron to Fe(3)O(4).	Iron	9-13	latexin	Homo sapiens	69-72
23067376-7	2012	It is concluded that angiotensin promoted non-transferrin-bound iron uptake via AT-1 receptor activation, leading to EC oxidative functional impairment.	Iron	64-68	serotransferrin	Bos taurus	46-57
22840541-3	2012	When the iron powder was added to an aqueous ClO(4)(-) solution (104 muM) and the mixture was heated at 150 C, ClO(4)(-) concentration fell below 0.58 muM (58 mug L(-1), detection limit of ion chromatography) in 1 h, and Cl(-) was formed with the yield of 85% after 6 h. The decomposition was accompanied by transformation of the zerovalent iron to Fe(3)O(4).	Iron	9-13	latexin	Homo sapiens	151-154
22881289-0	2012	Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment.	Iron	18-22	heme oxygenase 1	Mus musculus	69-74
22808933-11	2012	Concerning RLS due to iron deficiency, a head-to-head study comparing efficacy, safety and compliance of oral iron versus intravenous one seems to be needed.	Iron	22-26	RLS1	Homo sapiens	11-14
22817335-0	2012	Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: beneficial role of glycine.	Iron	0-4	mitogen-activated protein kinase 1	Mus musculus	35-39
22817335-3	2012	Investigating cell signalling pathway, we observed that iron (FeSO4) intoxication caused NF-kappaB activation as well as the phosphorylation of p38 and ERK MAPKs.	Iron	56-60	mitogen-activated protein kinase 1	Mus musculus	152-155
22817335-4	2012	Iron (FeSO4) administration also disrupted Bcl-2/Bad protein balance, reduced mitochondrial membrane potential, released cytochrome c and induced the activation of caspases and cleavage of PARP protein.	Iron	0-4	B cell leukemia/lymphoma 2	Mus musculus	43-48
24082455-0	2012	Non transferrin bound iron: nature, manifestations and analytical approaches for estimation.	Iron	22-26	transferrin	Homo sapiens	4-15
24082455-3	2012	Major portion of iron in circulation is associated with transferrin, a classical iron transporter, which prevent the existence of free iron.	Iron	17-21	transferrin	Homo sapiens	56-67
24082455-3	2012	Major portion of iron in circulation is associated with transferrin, a classical iron transporter, which prevent the existence of free iron.	Iron	81-85	transferrin	Homo sapiens	56-67
24082455-4	2012	The fraction of iron which is free of transferrin is known as "non transferrin bound iron".	Iron	16-20	transferrin	Homo sapiens	38-49
24082455-4	2012	The fraction of iron which is free of transferrin is known as "non transferrin bound iron".	Iron	16-20	transferrin	Homo sapiens	67-78
24082455-4	2012	The fraction of iron which is free of transferrin is known as "non transferrin bound iron".	Iron	85-89	transferrin	Homo sapiens	38-49
24082455-4	2012	The fraction of iron which is free of transferrin is known as "non transferrin bound iron".	Iron	85-89	transferrin	Homo sapiens	67-78
24082455-5	2012	Along with the incidence in iron over loaded patient non transferrin bound iron has been indicated in patients without iron overload.	Iron	28-32	transferrin	Homo sapiens	57-68
24082455-5	2012	Along with the incidence in iron over loaded patient non transferrin bound iron has been indicated in patients without iron overload.	Iron	75-79	transferrin	Homo sapiens	57-68
24082455-5	2012	Along with the incidence in iron over loaded patient non transferrin bound iron has been indicated in patients without iron overload.	Iron	75-79	transferrin	Homo sapiens	57-68
24082455-10	2012	Non transferrin bound iron has obvious chance to generate the free reactive radicals as it is not been shielded by the protective carrier protein apo transferrin.	Iron	22-26	transferrin	Homo sapiens	4-15
24082455-10	2012	Non transferrin bound iron has obvious chance to generate the free reactive radicals as it is not been shielded by the protective carrier protein apo transferrin.	Iron	22-26	transferrin	Homo sapiens	150-161
24082455-11	2012	The nature of non transferrin bound iron is not clear at present time but it is definitely a group of heterogenous iron forms free from transferrin and ferritin.	Iron	36-40	transferrin	Homo sapiens	18-29
24082455-13	2012	have been experimented in different research laboratories for estimation of non transferrin bound iron.	Iron	98-102	transferrin	Homo sapiens	80-91
22881289-5	2012	At 48 weeks, the GFAP.HMOX1 mice exhibited increased deposits of glial iron in hippocampus and other subcortical regions without overt changes in iron-regulatory and iron-binding proteins relative to age-matched wild-type animals.	Iron	71-75	heme oxygenase 1	Mus musculus	22-27
22881289-7	2012	Sustained up-regulation of HO-1 in astrocytes promotes pathological brain iron deposition and oxidative mitochondrial damage characteristic of Alzheimer"s disease-affected neural tissues.	Iron	74-78	heme oxygenase 1	Mus musculus	27-31
22996660-0	2012	Adipocyte iron regulates adiponectin and insulin sensitivity.	Iron	10-14	adiponectin, C1Q and collagen domain containing	Homo sapiens	25-36
22996660-0	2012	Adipocyte iron regulates adiponectin and insulin sensitivity.	Iron	10-14	insulin	Homo sapiens	41-48
22996660-2	2012	We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients.	Iron	40-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-59
22996660-6	2012	We found that iron negatively regulated adiponectin transcription via FOXO1-mediated repression.	Iron	14-18	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-51
22996660-6	2012	We found that iron negatively regulated adiponectin transcription via FOXO1-mediated repression.	Iron	14-18	forkhead box O1	Homo sapiens	70-75
22996660-7	2012	Further, loss of the adipocyte iron export channel, ferroportin, in mice resulted in adipocyte iron loading, decreased adiponectin, and insulin resistance.	Iron	31-35	insulin	Homo sapiens	136-143
22996660-8	2012	Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity.	Iron	23-27	adiponectin, C1Q and collagen domain containing	Homo sapiens	167-178
22996660-8	2012	Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity.	Iron	23-27	insulin	Homo sapiens	222-229
22996660-10	2012	These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores.	Iron	176-180	adiponectin, C1Q and collagen domain containing	Homo sapiens	149-160
22985399-4	2012	A previous study indicated that ASP may increase plasma iron levels by suppressing the expression of hepcidin, a negative regulator of body iron metabolism, in the liver.	Iron	56-60	hepcidin antimicrobial peptide	Rattus norvegicus	101-109
22985399-4	2012	A previous study indicated that ASP may increase plasma iron levels by suppressing the expression of hepcidin, a negative regulator of body iron metabolism, in the liver.	Iron	140-144	hepcidin antimicrobial peptide	Rattus norvegicus	101-109
22881289-3	2012	HO-1 induction in primary astroglial cultures promotes deposition of non-transferrin iron, mitochondrial damage and macroautophagy, and predisposes cocultured neuronal elements to oxidative injury.	Iron	85-89	heme oxygenase 1	Mus musculus	0-4
22961109-4	2012	Mechanistically, we also found that mitoNEET inhibits mitochondrial iron transport into the matrix and, because iron is a rate-limiting component for electron transport, lowers the rate of beta-oxidation.	Iron	68-72	CDGSH iron sulfur domain 1	Mus musculus	36-44
23043066-2	2012	The oxygenation of iron is a requisite for transferrin transport of iron and keeping noxious Fe2+ low.	Iron	19-23	transferrin	Homo sapiens	43-54
23043066-2	2012	The oxygenation of iron is a requisite for transferrin transport of iron and keeping noxious Fe2+ low.	Iron	68-72	transferrin	Homo sapiens	43-54
22732705-0	2012	Differential participation of phospholipase A2 isoforms during iron-induced retinal toxicity.	Iron	63-67	phospholipase A2 group IB	Homo sapiens	30-46
22732705-3	2012	The role of phospholipase A(2) (PLA(2)) during iron-induced retinal toxicity was investigated.	Iron	47-51	phospholipase A2 group IB	Homo sapiens	32-38
22732705-6	2012	A differential release of arachidonic acid (AA) and palmitic acid (PAL) catalyzed by cPLA(2) and iPLA(2) activities, respectively, was also observed in microsomal and cytosolic fractions obtained from retinas incubated with iron.	Iron	224-228	phospholipase A2 group VI	Homo sapiens	97-104
22732705-7	2012	AA release diminished as the association of cyclooxygenase-2 increased in microsomes from retinas exposed to iron.	Iron	109-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-60
22957710-0	2012	The transferrin-iron import system from pathogenic Neisseria species.	Iron	16-20	transferrin	Homo sapiens	4-15
22957710-6	2012	These efforts have been boosted by recent reports of the crystal structures of the neisserial receptor proteins TbpA and TbpB, each solved in complex with human transferrin, an iron binding protein normally responsible for delivering iron to human cells.	Iron	177-181	transferrin	Homo sapiens	161-172
22957710-6	2012	These efforts have been boosted by recent reports of the crystal structures of the neisserial receptor proteins TbpA and TbpB, each solved in complex with human transferrin, an iron binding protein normally responsible for delivering iron to human cells.	Iron	234-238	transferrin	Homo sapiens	161-172
22961109-4	2012	Mechanistically, we also found that mitoNEET inhibits mitochondrial iron transport into the matrix and, because iron is a rate-limiting component for electron transport, lowers the rate of beta-oxidation.	Iron	112-116	CDGSH iron sulfur domain 1	Mus musculus	36-44
22961109-6	2012	Conversely, a reduction in mitoNEET expression enhances mitochondrial respiratory capacity through enhanced iron content in the matrix, ultimately corresponding to less weight gain on a high-fat diet.	Iron	108-112	CDGSH iron sulfur domain 1	Mus musculus	27-35
22854259-10	2012	The identification of predictors such as medical comorbidities, and protectors such as folate and iron supplements, is warranted for obstetric RLS.	Iron	98-102	RLS1	Homo sapiens	143-146
22349676-5	2012	Compared with the control subjects, the patients had increased levels of oxidant biomarkers including malondialdehyde, protein carbonyl, and non-transferrin-bound iron and a decreased glutathione redox ratio.	Iron	163-167	transferrin	Homo sapiens	145-156
23104832-0	2012	The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster assembly pathway to maintain nuclear genome integrity in Arabidopsis.	Iron	48-52	MIP18 family protein (DUF59)	Arabidopsis thaliana	22-25
23104832-2	2012	Here, we report that asymmetric leaves1/2 enhancer7 (AE7), an Arabidopsis thaliana gene encoding a protein in the evolutionarily conserved Domain of Unknown Function 59 family, participates in the cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway to maintain genome integrity.	Iron	207-211	MIP18 family protein (DUF59)	Arabidopsis thaliana	53-56
23104832-2	2012	Here, we report that asymmetric leaves1/2 enhancer7 (AE7), an Arabidopsis thaliana gene encoding a protein in the evolutionarily conserved Domain of Unknown Function 59 family, participates in the cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway to maintain genome integrity.	Iron	220-224	MIP18 family protein (DUF59)	Arabidopsis thaliana	53-56
23104832-4	2012	AE7 is part of a protein complex with CIA1, NAR1, and MET18, which are highly conserved in eukaryotes and are involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	162-166	MIP18 family protein (DUF59)	Arabidopsis thaliana	0-3
23104832-7	2012	These results indicate that AE7 is a central member of the CIA pathway, linking plant mitochondria to nuclear genome integrity through assembly of Fe-S proteins.	Iron	147-151	MIP18 family protein (DUF59)	Arabidopsis thaliana	28-31
22935044-3	2012	We suggest that unbound iron binding capacity (UIBC), which is s-total iron binding capacity (2 times s-transferrin) minus s-iron could be used for diagnosing empty iron stores.	Iron	24-28	transferrin	Homo sapiens	104-115
22935044-3	2012	We suggest that unbound iron binding capacity (UIBC), which is s-total iron binding capacity (2 times s-transferrin) minus s-iron could be used for diagnosing empty iron stores.	Iron	71-75	transferrin	Homo sapiens	104-115
22935044-3	2012	We suggest that unbound iron binding capacity (UIBC), which is s-total iron binding capacity (2 times s-transferrin) minus s-iron could be used for diagnosing empty iron stores.	Iron	71-75	transferrin	Homo sapiens	104-115
22935044-3	2012	We suggest that unbound iron binding capacity (UIBC), which is s-total iron binding capacity (2 times s-transferrin) minus s-iron could be used for diagnosing empty iron stores.	Iron	71-75	transferrin	Homo sapiens	104-115
22935044-8	2012	CONCLUSION: When diagnosing empty iron stores calculation of s-UIBC is a better way to utilize the information in s-iron and s-transferrin than is calculation of s-transferrin saturation.	Iron	34-38	transferrin	Homo sapiens	127-138
22935044-8	2012	CONCLUSION: When diagnosing empty iron stores calculation of s-UIBC is a better way to utilize the information in s-iron and s-transferrin than is calculation of s-transferrin saturation.	Iron	34-38	transferrin	Homo sapiens	164-175
22237814-0	2012	Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells.	Iron	0-4	HHIP like 2	Homo sapiens	19-26
22237814-3	2012	HHIPL-2 is an iron-modulated gene which could contribute to these alterations.	Iron	14-18	HHIP like 2	Homo sapiens	0-7
22237814-13	2012	The level of mRNA alpha 1 collagen type I chain, osteocalcin and the transcriptional factor RUNX2 were decreased by iron.	Iron	116-120	bone gamma-carboxyglutamate protein	Homo sapiens	49-60
22237814-13	2012	The level of mRNA alpha 1 collagen type I chain, osteocalcin and the transcriptional factor RUNX2 were decreased by iron.	Iron	116-120	RUNX family transcription factor 2	Homo sapiens	92-97
22579050-2	2012	Iron overload may lead also to insulin resistance and diabetes.	Iron	0-4	insulin	Homo sapiens	31-38
22835769-0	2012	Iron-complexed adsorptive membrane for As(V) species in water.	Iron	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	39-44
22938093-1	2012	The organic extract of a marine sponge, Petrosia alfiani, selectively inhibited iron chelator-induced hypoxia-inducible factor-1 (HIF-1) activation in a human breast tumor T47D cell-based reporter assay.	Iron	80-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-128
22938093-1	2012	The organic extract of a marine sponge, Petrosia alfiani, selectively inhibited iron chelator-induced hypoxia-inducible factor-1 (HIF-1) activation in a human breast tumor T47D cell-based reporter assay.	Iron	80-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-135
22692681-0	2012	Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties.	Iron	138-142	pantothenate kinase 2	Homo sapiens	22-70
22579050-4	2012	Factors contributing to potential iron overload in PCOS include the iron sparing effect of chronic menstrual dysfunction, insulin resistance, and a decrease in hepcidin leading to increased iron absorption.	Iron	34-38	insulin	Homo sapiens	122-129
22692681-4	2012	To investigate the link between a PANK2 gene defect and iron accumulation, we analyzed primary skin fibroblasts from three PKAN patients and three unaffected subjects.	Iron	56-60	pantothenate kinase 2	Homo sapiens	34-39
22692681-7	2012	After iron supplementation, the PKAN fibroblasts had a defective response to the additional iron.	Iron	6-10	pantothenate kinase 2	Homo sapiens	32-36
22692681-7	2012	After iron supplementation, the PKAN fibroblasts had a defective response to the additional iron.	Iron	92-96	pantothenate kinase 2	Homo sapiens	32-36
22692681-9	2012	Analysis of iron regulatory proteins (IRPs) reveals that, with respect to the controls, PKAN fibroblasts have a reduced amount of membrane-associated mRNA-bound IRP1, which responds imperfectly to iron.	Iron	12-16	pantothenate kinase 2	Homo sapiens	88-92
22692681-9	2012	Analysis of iron regulatory proteins (IRPs) reveals that, with respect to the controls, PKAN fibroblasts have a reduced amount of membrane-associated mRNA-bound IRP1, which responds imperfectly to iron.	Iron	197-201	pantothenate kinase 2	Homo sapiens	88-92
22692681-12	2012	Our results suggest that Pank2 deficiency promotes an increased oxidative status that is further enhanced by the addition of iron, potentially causing damage in cells.	Iron	125-129	pantothenate kinase 2	Homo sapiens	25-30
22706064-15	2012	Identification of putative Fur boxes and expression of the genes under iron-depleted conditions revealed which genes and operons are components of the Fur regulon.	Iron	71-75	ferric iron uptake transcriptional regulator	Cronobacter sakazakii	27-30
27847448-5	2012	AA oxidation induced by iron/EDTA complex was significantly reduced by addition of superoxide dismutase, catalase and DTT to the reaction medium.	Iron	24-28	catalase	Homo sapiens	105-113
22924695-1	2012	Activation of the corrinoid [Fe-S] protein (CoFeSP), involved in reductive CO(2) conversion, requires the reduction of the Co(II) center by the [Fe-S] protein RACo, which according to the reduction potentials of the two proteins would correspond to an uphill electron transfer.	Iron	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
22873711-0	2012	Molecular dynamics simulations of iron- and aluminum-loaded serum transferrin: protonation of Tyr188 is necessary to prompt metal release.	Iron	34-38	transferrin	Homo sapiens	66-77
22873711-1	2012	Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-mediated endocytosis.	Iron	32-36	transferrin	Homo sapiens	6-17
22706064-15	2012	Identification of putative Fur boxes and expression of the genes under iron-depleted conditions revealed which genes and operons are components of the Fur regulon.	Iron	71-75	ferric iron uptake transcriptional regulator	Cronobacter sakazakii	151-154
22609301-10	2012	In mammalian cells, the iron regulatory proteins IRP1, an Fe/S protein, and IRP2 act in a post-transcriptional fashion to adjust the cellular needs for iron.	Iron	24-28	iron responsive element binding protein 2	Homo sapiens	76-80
22285816-4	2012	The transferrin cycle is a well-studied iron uptake pathway that is important for most vertebrate cells.	Iron	40-44	transferrin	Homo sapiens	4-15
22285816-7	2012	This review focuses on canonical transferrin-mediated and the newly discovered, non-transferrin mediated iron uptake pathways, as well as, mitochondrial iron homeostasis in higher eukaryotes.	Iron	105-109	transferrin	Homo sapiens	84-95
22609301-10	2012	In mammalian cells, the iron regulatory proteins IRP1, an Fe/S protein, and IRP2 act in a post-transcriptional fashion to adjust the cellular needs for iron.	Iron	152-156	iron responsive element binding protein 2	Homo sapiens	76-80
22610083-1	2012	Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	86-90
22610083-1	2012	Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).	Iron	43-47	iron responsive element binding protein 2	Homo sapiens	86-90
22473803-0	2012	Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice.	Iron	95-99	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-12
22765023-0	2012	Two novel mutations in the tmprss6 gene associated with iron-refractory iron-deficiency anaemia (irida) and partial expression in the heterozygous form.	Iron	56-60	transmembrane serine protease 6	Homo sapiens	27-34
22861364-1	2012	The transferrin (Tf) family of iron binding proteins includes important endogenous modulators of the immune function that may modulate autoimmune diseases.	Iron	31-35	transferrin	Homo sapiens	4-15
22861364-1	2012	The transferrin (Tf) family of iron binding proteins includes important endogenous modulators of the immune function that may modulate autoimmune diseases.	Iron	31-35	transferrin	Homo sapiens	17-19
22560182-0	2012	Heterogeneous reductive dehalogenation of PCB contaminated transformer oil and brominated diphenyl ethers with zero valent iron.	Iron	123-127	pyruvate carboxylase	Homo sapiens	42-45
23240214-3	2012	Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0).	Iron	118-120	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
23240214-3	2012	Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0).	Iron	118-120	CD59 molecule (CD59 blood group)	Homo sapiens	179-185
23240214-3	2012	Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0).	Iron	231-233	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
22699086-5	2012	In this study, we investigated the injury to hepatocytes CYP2E1-independently induced by the combination of alcohol and iron and the protective effect of baicalin.	Iron	120-124	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	57-63
22473803-3	2012	We hypothesized that the iron exporter, ferroportin1 (Fpn1), is critical for both iron mobilization from hepatocytes and iron recycling from macrophages.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	40-52
22473803-3	2012	We hypothesized that the iron exporter, ferroportin1 (Fpn1), is critical for both iron mobilization from hepatocytes and iron recycling from macrophages.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	54-58
22473803-5	2012	When fed a standard diet, Fpn1(Alb/Alb) mice showed mild hepatocyte iron retention.	Iron	68-72	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	26-30
22473803-7	2012	When fed an iron-deficient diet, Fpn1(Alb/Alb) mice showed impaired liver iron mobilization and anemia, with much lower RBC and Hb levels than Fpn1(flox/flox) mice on the same diet.	Iron	12-16	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	33-37
22473803-9	2012	On a standard diet, Fpn1(Alb/Alb;LysM/LysM) mice displayed substantial iron retention in hepatocytes and macrophages, yet maintained intact erythropoiesis, implying a compensatory role for intestinal iron absorption.	Iron	71-75	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	20-24
22473803-3	2012	We hypothesized that the iron exporter, ferroportin1 (Fpn1), is critical for both iron mobilization from hepatocytes and iron recycling from macrophages.	Iron	25-29	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	40-52
22473803-9	2012	On a standard diet, Fpn1(Alb/Alb;LysM/LysM) mice displayed substantial iron retention in hepatocytes and macrophages, yet maintained intact erythropoiesis, implying a compensatory role for intestinal iron absorption.	Iron	71-75	lysozyme 2	Mus musculus	33-37
22473803-9	2012	On a standard diet, Fpn1(Alb/Alb;LysM/LysM) mice displayed substantial iron retention in hepatocytes and macrophages, yet maintained intact erythropoiesis, implying a compensatory role for intestinal iron absorption.	Iron	71-75	lysozyme 2	Mus musculus	38-42
22473803-3	2012	We hypothesized that the iron exporter, ferroportin1 (Fpn1), is critical for both iron mobilization from hepatocytes and iron recycling from macrophages.	Iron	25-29	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	54-58
22473803-9	2012	On a standard diet, Fpn1(Alb/Alb;LysM/LysM) mice displayed substantial iron retention in hepatocytes and macrophages, yet maintained intact erythropoiesis, implying a compensatory role for intestinal iron absorption.	Iron	200-204	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	20-24
22473803-10	2012	In contrast, when Fpn1(Alb/Alb;LysM/LysM) mice were fed an iron-deficient diet, they developed severe iron-deficiency anemia, regardless of their iron storage status.	Iron	59-63	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	18-22
22473803-3	2012	We hypothesized that the iron exporter, ferroportin1 (Fpn1), is critical for both iron mobilization from hepatocytes and iron recycling from macrophages.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	40-52
22473803-10	2012	In contrast, when Fpn1(Alb/Alb;LysM/LysM) mice were fed an iron-deficient diet, they developed severe iron-deficiency anemia, regardless of their iron storage status.	Iron	59-63	lysozyme 2	Mus musculus	31-35
22473803-10	2012	In contrast, when Fpn1(Alb/Alb;LysM/LysM) mice were fed an iron-deficient diet, they developed severe iron-deficiency anemia, regardless of their iron storage status.	Iron	102-106	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	18-22
22473803-3	2012	We hypothesized that the iron exporter, ferroportin1 (Fpn1), is critical for both iron mobilization from hepatocytes and iron recycling from macrophages.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	54-58
22473803-10	2012	In contrast, when Fpn1(Alb/Alb;LysM/LysM) mice were fed an iron-deficient diet, they developed severe iron-deficiency anemia, regardless of their iron storage status.	Iron	102-106	lysozyme 2	Mus musculus	31-35
22473803-11	2012	Thus, Fpn1 is critical for both hepatocyte iron mobilization and macrophage iron recycling during conditions of dietary iron deficiency.	Iron	43-47	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	6-10
22473803-11	2012	Thus, Fpn1 is critical for both hepatocyte iron mobilization and macrophage iron recycling during conditions of dietary iron deficiency.	Iron	76-80	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	6-10
22473803-12	2012	CONCLUSION: Our data reveal new insights into the relationships between Fpn1-mediated iron mobilization, iron storage, and intestinal iron absorption and how these processes interact to maintain systemic iron homeostasis.	Iron	86-90	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	72-76
22473803-12	2012	CONCLUSION: Our data reveal new insights into the relationships between Fpn1-mediated iron mobilization, iron storage, and intestinal iron absorption and how these processes interact to maintain systemic iron homeostasis.	Iron	105-109	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	72-76
22473803-12	2012	CONCLUSION: Our data reveal new insights into the relationships between Fpn1-mediated iron mobilization, iron storage, and intestinal iron absorption and how these processes interact to maintain systemic iron homeostasis.	Iron	105-109	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	72-76
22673340-0	2012	Fate of As(V)-treated nano zero-valent iron: determination of arsenic desorption potential under varying environmental conditions by phosphate extraction.	Iron	39-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	8-13
22473803-12	2012	CONCLUSION: Our data reveal new insights into the relationships between Fpn1-mediated iron mobilization, iron storage, and intestinal iron absorption and how these processes interact to maintain systemic iron homeostasis.	Iron	105-109	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	72-76
23071474-13	2012	CONCLUSION: We demonstrated that deferasirox, a new oral iron-chelating agent, induced early apoptosis in human malignant lymphoma cells, and this apoptotic effect is dependent on the caspase-3/caspase-9 pathway.	Iron	57-61	caspase 3	Homo sapiens	184-193
22488824-5	2012	Here, we show by means of electron microscopy that iron ions added to human blood dramatically enhances fibrin fibers formation with thrombin, and significantly delays fibrinolysis during spontaneous clotting of native blood.	Iron	51-55	coagulation factor II, thrombin	Homo sapiens	133-141
22649188-0	2012	Elevated hepatic iron activates NF-E2-related factor 2-regulated pathway in a dietary iron overload mouse model.	Iron	17-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-54
22649188-0	2012	Elevated hepatic iron activates NF-E2-related factor 2-regulated pathway in a dietary iron overload mouse model.	Iron	86-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-54
22649188-10	2012	We conclude that elevated hepatic iron in a mouse model activates NRF2, a key regulator of the cellular response to oxidative stress.	Iron	34-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
23156704-2	2012	In humans, insulin resistance is associated with liver pathologies, including excessive iron deposition and nonalcoholic fatty liver disease.	Iron	88-92	insulin	Homo sapiens	11-18
22836558-8	2012	Iron homeostasis is mainly regulated by transferrin, which transports ferric ions to other cells.	Iron	0-4	transferrin	Homo sapiens	40-51
22836558-9	2012	Transferrin-bound iron is internalised via endocytosis mediated by transferrin receptor.	Iron	18-22	transferrin	Homo sapiens	0-11
22836558-9	2012	Transferrin-bound iron is internalised via endocytosis mediated by transferrin receptor.	Iron	18-22	transferrin	Homo sapiens	67-78
22836558-11	2012	Other non hemo-iron related antioxidant enzymes (e.g. superoxide dismutase, catalase, thioredoxin and peroxiredoxin) are also involved in redox modulation in vascular remodelling.	Iron	15-19	catalase	Homo sapiens	76-84
22871140-4	2012	Iron chelators, such as EDTA, desferrioxamine, and deferiprone, were found to cause the nanoshells to degrade on the removal of iron(III) within several days at 80  C. When the iron(III)-doped, silica nanoshells were submerged in fetal bovine and human serums at physiological temperature, they also degrade via removal of the iron by serum proteins, such as transferrin, over a period of several weeks.	Iron	0-4	serotransferrin	Bos taurus	359-370
22747465-2	2012	(Fe(2+) + alphaKG)PHD2 is 6-coordinate, with a 2His/1Asp facial triad occupying three coordination sites, a bidentate alpha-ketoglutarate occupying two sites, and an aquo ligand in the final site.	Iron	1-3	egl-9 family hypoxia inducible factor 1	Homo sapiens	18-22
22803508-2	2012	Once in a complex with cardiolipin, cytochrome c has been shown to undergo a conformational change that leads to the rupture of the bond between the heme iron and the intrinsic sulfur ligand of a methionine residue and to enhance the peroxidatic properties of the protein considered important to its apoptotic activity.	Iron	154-158	cytochrome c, somatic	Homo sapiens	36-48
22847425-9	2012	We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.	Iron	90-94	Transferrin 2	Drosophila melanogaster	122-139
22847425-9	2012	We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.	Iron	90-94	Transferrin 2	Drosophila melanogaster	122-139
22847425-9	2012	We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.	Iron	90-94	Transferrin 2	Drosophila melanogaster	122-139
21899903-10	2012	M-FR was lower in TSAT&lt;15% than in TSAT &gt;= 15% (LV -31 +- 26 vs 46 +- 29; p=0.07) and (RV -24 +- 24 vs 43 +- 29; p=0.02), without differences in M-Iron and M-sTfR.	Iron	153-157	signal regulatory protein alpha	Homo sapiens	0-4
22823905-7	2012	The origin lies in the redistribution of Fe 3d orbital occupation with the change of crystal field, where successive structural transitions from ambient pressure phase Fd3[combining overline]m to high pressure phase Pbcm (at 29.7 GPa) and further to Bbmm (at 65.1 GPa) are established accurately.	Iron	41-43	glycophorin A (MNS blood group)	Homo sapiens	230-233
22823905-7	2012	The origin lies in the redistribution of Fe 3d orbital occupation with the change of crystal field, where successive structural transitions from ambient pressure phase Fd3[combining overline]m to high pressure phase Pbcm (at 29.7 GPa) and further to Bbmm (at 65.1 GPa) are established accurately.	Iron	41-43	glycophorin A (MNS blood group)	Homo sapiens	264-267
21899903-13	2012	In reduced serum iron group, decrease in myocardial storage protein M-FR was observed.	Iron	17-21	signal regulatory protein alpha	Homo sapiens	68-72
22876027-3	2012	Hyperferritinemia and iron stores have been associated with the severity of liver damage in NAFLD, and iron depletion reduced insulin resistance and liver enzymes.	Iron	103-107	insulin	Homo sapiens	126-133
22659129-0	2012	High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats.	Iron	44-48	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
22777991-9	2012	Compared with placebo, iron supplementation increased hemoglobin (0.32 g/dL; p=0.002) and ferritin (11.4 mug/L; p&lt;0.001) and decreased soluble transferrin receptor (-0.54 mg/L; p&lt;0.001) at 12 weeks.	Iron	23-27	transferrin	Homo sapiens	146-157
22696214-4	2012	However, in a condition of persistent free heme overload in malaria, the overactivity of HO-1 resulted in continuous transient generation of free iron to favor production of reactive oxidants as evident from 2",7"-dichlorofluorescein fluorescence studies.	Iron	146-150	heme oxygenase 1	Mus musculus	89-93
22659129-0	2012	High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats.	Iron	82-86	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
22328310-0	2012	C-reactive protein, waist circumference, and family history of heart attack are independent predictors of body iron stores in apparently healthy premenopausal women.	Iron	111-115	C-reactive protein	Homo sapiens	0-18
22659129-1	2012	Hepcidin is considered to be a circulatory hormone and a major mechanism regulating iron homeostasis.	Iron	84-88	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
22659129-3	2012	However, whether and how hepcidin functions in this nigral iron accumulation has not been elucidated.	Iron	59-63	hepcidin antimicrobial peptide	Rattus norvegicus	25-33
22659129-4	2012	In the present study, we observed a decreased of FPN1 protein level in the SN triggered by peripheral iron overload within 4 h, which correlated with a high hepcidin level.	Iron	102-106	solute carrier family 40 member 1	Rattus norvegicus	49-53
22659129-6	2012	We observed that hepcidin mRNA level was up-regulated and FPN1 protein level was down-regulated in MES23.5 dopaminergic cells in a period of 4h incubation with iron.	Iron	160-164	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
22659129-6	2012	We observed that hepcidin mRNA level was up-regulated and FPN1 protein level was down-regulated in MES23.5 dopaminergic cells in a period of 4h incubation with iron.	Iron	160-164	solute carrier family 40 member 1	Rattus norvegicus	58-62
22659129-8	2012	Our data provide direct evidence that the role for intracellular hepcidin generated in the SN is particularly relevant to restrict iron release by down-regulation FPN1 expression in this region, thus an important contributor to the abnormal iron deposit occurred at an early stage in conditions of peripheral iron intoxication.	Iron	131-135	hepcidin antimicrobial peptide	Rattus norvegicus	65-73
22659129-8	2012	Our data provide direct evidence that the role for intracellular hepcidin generated in the SN is particularly relevant to restrict iron release by down-regulation FPN1 expression in this region, thus an important contributor to the abnormal iron deposit occurred at an early stage in conditions of peripheral iron intoxication.	Iron	241-245	hepcidin antimicrobial peptide	Rattus norvegicus	65-73
22659129-8	2012	Our data provide direct evidence that the role for intracellular hepcidin generated in the SN is particularly relevant to restrict iron release by down-regulation FPN1 expression in this region, thus an important contributor to the abnormal iron deposit occurred at an early stage in conditions of peripheral iron intoxication.	Iron	241-245	hepcidin antimicrobial peptide	Rattus norvegicus	65-73
22294463-0	2012	Known and potential roles of transferrin in iron biology.	Iron	44-48	transferrin	Homo sapiens	29-40
22294463-1	2012	Transferrin is an abundant serum metal-binding protein best known for its role in iron delivery.	Iron	82-86	transferrin	Homo sapiens	0-11
22294463-2	2012	The human disease congenital atransferrinemia and animal models of this disease highlight the essential role of transferrin in erythropoiesis and iron metabolism.	Iron	146-150	transferrin	Homo sapiens	30-41
22770994-5	2012	We found that 10-week treatment of apoE-/- mice with TTM (33-66 ppm in the diet) reduced serum levels of the copper-containing protein, ceruloplasmin, by 47%, and serum iron by 26%.	Iron	169-173	apolipoprotein E	Mus musculus	35-39
22434419-8	2012	This indicates that the iron reduced from holo-transferrin at the plasma membrane accounts for at least 50 % of the iron uptake observed.	Iron	24-28	transferrin	Homo sapiens	47-58
22434419-5	2012	Blocking holo-Tf binding with an anti-TfR antibody significantly decreases the reduction of iron from transferrin by hBMVEC, suggesting that holo-Tf needs to bind to TfR in order for efficient reduction to occur.	Iron	92-96	transferrin	Homo sapiens	102-113
22310887-1	2012	Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin cycle.	Iron	67-71	transferrin	Homo sapiens	142-153
22310887-1	2012	Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin cycle.	Iron	106-110	transferrin	Homo sapiens	142-153
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	46-48	tumor necrosis factor	Homo sapiens	135-144
22434419-8	2012	This indicates that the iron reduced from holo-transferrin at the plasma membrane accounts for at least 50 % of the iron uptake observed.	Iron	116-120	transferrin	Homo sapiens	47-58
22476617-10	2012	3T3-L1 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 showed increased NF-kappaB mRNA expression and decreased Mfn-2 expression in all experimental conditions.	Iron	35-37	interleukin 6	Mus musculus	78-82
22476617-10	2012	3T3-L1 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 showed increased NF-kappaB mRNA expression and decreased Mfn-2 expression in all experimental conditions.	Iron	35-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-109
22476617-8	2012	3T3-L1 cells showed an increase in intracellular Fe with high Fe plus either IL-6 or CoCl(2).	Iron	49-51	interleukin 6	Mus musculus	77-81
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	34-36	interleukin 6	Homo sapiens	77-81
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	34-36	interleukin 6	Homo sapiens	114-118
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	34-36	nuclear factor kappa B subunit 1	Homo sapiens	120-129
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	34-36	tumor necrosis factor	Homo sapiens	135-144
22526560-0	2012	Sub-lethal levels of amyloid beta-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons.	Iron	83-87	transferrin	Homo sapiens	65-76
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	46-48	interleukin 6	Homo sapiens	77-81
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	46-48	interleukin 6	Homo sapiens	114-118
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	46-48	nuclear factor kappa B subunit 1	Homo sapiens	120-129
22829296-2	2012	Metal ions (e.g. Cu, Fe, and Zn) are supposed to induce the aggregation of Abeta.	Iron	21-23	amyloid beta precursor protein	Homo sapiens	75-80
22817703-3	2012	On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c, leading towards a single protein characterization scheme in a natural environment.	Iron	122-126	cytochrome c, somatic	Homo sapiens	134-146
22515741-1	2012	Pantothenate kinase-associated neurodegeneration (PKAN) is a hereditary progressive disorder and the most frequent form of neurodegeneration with brain iron accumulation (NBIA).	Iron	152-156	pantothenate kinase 2	Homo sapiens	0-48
22515741-1	2012	Pantothenate kinase-associated neurodegeneration (PKAN) is a hereditary progressive disorder and the most frequent form of neurodegeneration with brain iron accumulation (NBIA).	Iron	152-156	pantothenate kinase 2	Homo sapiens	50-54
22515741-3	2012	In magnetic resonance imaging, PKAN patients exhibit the pathognonomic "eye of the tiger" sign in the globus pallidus which corresponds to iron accumulation and gliosis as shown in neuropathological examinations.	Iron	139-143	pantothenate kinase 2	Homo sapiens	31-35
22515743-0	2012	PLA2G6 mutations and other rare causes of neurodegeneration with brain iron accumulation.	Iron	71-75	phospholipase A2 group VI	Homo sapiens	0-6
22883617-3	2012	Our central hypotheses were that, by the completion of treatment, serum iron would increase, serum concentrations of interleukin-6 (IL-6) and hepcidin-25, two mediators of hypoferremia, would decrease, and sputum iron would decrease.	Iron	72-76	interleukin 6	Homo sapiens	132-136
22334511-7	2012	In HCV patients a single dose of PEG-IFN-alpha/RBV resulted in a significant increase in serum hepcidin, peaking at 12 hours, coinciding with a 50% reduction in serum iron and transferrin saturation over the 24-hour period.	Iron	167-171	interferon alpha 1	Homo sapiens	37-46
22367278-0	2012	Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.	Iron	22-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
22367278-7	2012	Iron accumulation was greater in the livers of the Nrf2-null mice compared to those of the WT mice, and it was not observed in Keap1-kd.	Iron	0-4	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
22367278-8	2012	Further, the iron release from the isolated hepatocyte of Nrf2-null mice was significantly decreased.	Iron	13-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	58-62
22495295-1	2012	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, producing equimolar amounts of carbon monoxide, iron, and biliverdin.	Iron	126-130	heme oxygenase 1	Mus musculus	0-16
22367278-10	2012	CONCLUSIONS: Nrf2 has protective roles against nutritional steatohepatitis through inhibition of hepatic iron accumulation and counteraction against oxidative stress-induced liver injury.	Iron	105-109	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
22544439-5	2012	IL-6 production by RAW264.7 cells stimulated with lipopolysaccharide (LPS, TLR4 ligand) was enhanced by high amounts of iron present in the culture medium.	Iron	120-124	interleukin 6	Mus musculus	0-4
22544439-5	2012	IL-6 production by RAW264.7 cells stimulated with lipopolysaccharide (LPS, TLR4 ligand) was enhanced by high amounts of iron present in the culture medium.	Iron	120-124	toll-like receptor 4	Mus musculus	75-79
22495295-1	2012	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, producing equimolar amounts of carbon monoxide, iron, and biliverdin.	Iron	126-130	heme oxygenase 1	Mus musculus	18-22
22075215-10	2012	Some evidence suggests that dysfunction in iron metabolism and high estrogen levels might contribute to RLS during pregnancy.	Iron	43-47	RLS1	Homo sapiens	104-107
22731657-9	2012	Women who had the greatest changes in iron over menopause (lower measures of premenopausal iron and greater increases in iron measures over the menopause) had the strongest associations between changes in iron and changes in insulin resistance.	Iron	38-42	insulin	Homo sapiens	225-232
21514009-0	2012	Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer"s disease.	Iron	61-65	transferrin	Homo sapiens	31-42
21514009-2	2012	In this context, hemochromatosis (Hfe) and transferrin (Tf) genes are of particular importance, since they play a key role in iron homeostasis.	Iron	126-130	transferrin	Homo sapiens	43-54
21514009-2	2012	In this context, hemochromatosis (Hfe) and transferrin (Tf) genes are of particular importance, since they play a key role in iron homeostasis.	Iron	126-130	transferrin	Homo sapiens	56-58
22731657-0	2012	Changes in iron measures over menopause and associations with insulin resistance.	Iron	11-15	insulin	Homo sapiens	62-69
22696679-9	2012	In addition, Met31p and Met32p appear to regulate iron-sulfur cluster biogenesis through direct and indirect mechanisms and have distinguishable target specificities.	Iron	50-54	Met32p	Saccharomyces cerevisiae S288C	24-30
22907175-3	2012	In this study, expression profiling of Saccharomyces cerevisiae in the presence of surplus iron revealed a dual effect at 1 and 4 h. A cluster of stress-responsive genes was upregulated via activation of the stress-resistance transcription factor Msn4, which indicated the stress effect of surplus iron on yeast metabolism.	Iron	91-95	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	247-251
22907175-3	2012	In this study, expression profiling of Saccharomyces cerevisiae in the presence of surplus iron revealed a dual effect at 1 and 4 h. A cluster of stress-responsive genes was upregulated via activation of the stress-resistance transcription factor Msn4, which indicated the stress effect of surplus iron on yeast metabolism.	Iron	298-302	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	247-251
22761074-11	2012	iron to be superior in increasing ferritin and transferrin saturation (TSAT) levels.	Iron	0-4	transferrin	Homo sapiens	47-58
22954919-6	2012	After the single dialysis, the two iron groups had higher level of serum MDA, MPO and lower level of serum SOD than that of the non-iron supplementation group (P&lt;0.01).	Iron	35-39	myeloperoxidase	Homo sapiens	78-81
22954919-6	2012	After the single dialysis, the two iron groups had higher level of serum MDA, MPO and lower level of serum SOD than that of the non-iron supplementation group (P&lt;0.01).	Iron	35-39	superoxide dismutase 1	Homo sapiens	107-110
22673561-3	2012	Binding constants (K(a)) in the solution state were calculated to be 3.88 x 10(5) M(-1) for Fe(2+) and 0.21 x 10(3) M(-1/2) for Fe(3+) and ratiometric detection limits for Fe(2+) and Fe(3+) were found to be 2.0 muM and 3.5 muM, respectively.	Iron	128-130	latexin	Homo sapiens	211-214
22673561-3	2012	Binding constants (K(a)) in the solution state were calculated to be 3.88 x 10(5) M(-1) for Fe(2+) and 0.21 x 10(3) M(-1/2) for Fe(3+) and ratiometric detection limits for Fe(2+) and Fe(3+) were found to be 2.0 muM and 3.5 muM, respectively.	Iron	128-130	latexin	Homo sapiens	223-226
22678362-4	2012	MMS19 functions as part of the CIA targeting complex that specifically interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance.	Iron	102-106	nuclear receptor coactivator 5	Homo sapiens	31-34
22768976-13	2012	CONCLUSIONS: HCV positive HD patients have low levels of serum prohepcidin and IL-6 which might account for iron accumulation together with lower iron and rhuEPO requirements in these patients.	Iron	108-112	interleukin 6	Homo sapiens	79-83
22525510-1	2012	The role of iron in surface-mediated formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) from 2-chlorophenol (2-MCP) was investigated over the temperature range of 200-550 C under oxidative conditions.	Iron	12-16	sallimus	Drosophila melanogaster	135-138
22648410-0	2012	Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.	Iron	101-105	F-box and leucine rich repeat protein 5	Homo sapiens	72-77
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Iron	95-99	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Iron	95-99	iron responsive element binding protein 2	Homo sapiens	56-60
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Iron	170-174	F-box and leucine rich repeat protein 5	Homo sapiens	42-47
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Iron	170-174	iron responsive element binding protein 2	Homo sapiens	56-60
22648410-2	2012	An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-replete conditions, whereas FBXL5 itself is degraded when iron and oxygen availability decreases.	Iron	170-174	F-box and leucine rich repeat protein 5	Homo sapiens	140-145
22648410-4	2012	Here, we investigated the iron- and oxygen-dependent conformational changes within FBXL5-Hr that underlie its role as a cellular sensor.	Iron	26-30	F-box and leucine rich repeat protein 5	Homo sapiens	83-88
22648410-5	2012	As predicted, FBXL5-Hr undergoes substantive structural changes when iron becomes limiting, accounting for its switch-like behavior.	Iron	69-73	F-box and leucine rich repeat protein 5	Homo sapiens	14-19
22768841-6	2012	Toxicity is mediated by sphingolipid signaling, as inactivation of the sphingolipid-activated protein kinases Pkh1p and Ypk1p and of the transcription factor Smp1p also enhances resistance to high iron conditions.	Iron	197-201	Smp1p	Saccharomyces cerevisiae S288C	158-163
22534198-3	2012	Under oxic conditions, the degradation of DZP achieved 96% after 60 min using Fe(0) (25 g L(-1)) pre-treated with H(2)SO(4) in the presence of EDTA (119 mg L(-1)), while mineralization achieved around 60% after the same time.	Iron	78-83	immunoglobulin kappa variable 1-16	Homo sapiens	90-95
22534198-3	2012	Under oxic conditions, the degradation of DZP achieved 96% after 60 min using Fe(0) (25 g L(-1)) pre-treated with H(2)SO(4) in the presence of EDTA (119 mg L(-1)), while mineralization achieved around 60% after the same time.	Iron	78-83	immunoglobulin kappa variable 1-16	Homo sapiens	156-161
22889519-6	2012	Iron-aggregated fibrinogen, by contrast to native molecule, could not be dissociated into polypeptide subunit chains as shown in a polyacrylamide gel electrophoresis.	Iron	0-4	fibrinogen beta chain	Homo sapiens	16-26
22270756-0	2012	Reduction of dinitrotoluene sulfonates in TNT red water using nanoscale zerovalent iron particles.	Iron	83-87	chromosome 16 open reading frame 82	Homo sapiens	42-45
22270756-1	2012	PURPOSE: This research was designed to investigate the feasibility of converting the dinitrotoluene sulfonates (DNTS) in TNT red water into the corresponding aromatic amino compounds using nanoscale zerovalent iron (NZVI).	Iron	210-214	chromosome 16 open reading frame 82	Homo sapiens	121-124
22889519-9	2012	In view of these findings, it is postulated that iron-induced alterations in fibrinogen structure is involved in pathogenesis of certain degenerative diseases associated with iron overload and persistent thrombosis.	Iron	49-53	fibrinogen beta chain	Homo sapiens	77-87
22889519-9	2012	In view of these findings, it is postulated that iron-induced alterations in fibrinogen structure is involved in pathogenesis of certain degenerative diseases associated with iron overload and persistent thrombosis.	Iron	175-179	fibrinogen beta chain	Homo sapiens	77-87
22465143-0	2012	Haptoglobin genotype and its role in determining heme-iron mediated vascular disease.	Iron	54-58	haptoglobin	Homo sapiens	0-11
23123988-19	2012	RECOMMENDATIONS FOR ERYTHROPOIETIN PLUS IRON: It is reasonable to administer erythropoietin preoperatively to increase red blood cell mass in patients who are anemic or refuse blood products (such as for Jehovah"s Witness faith) or who are likely to have postoperative anemia (Class IIa, Level A).	Iron	40-44	erythropoietin	Homo sapiens	77-91
22388977-2	2012	Apart from glycolysis, GAPDH participates in iron metabolism, membrane trafficking, histone biosynthesis, the maintenance of DNA integrity and receptor mediated cell signaling.	Iron	45-49	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	23-28
22544036-10	2012	In addition, this may confer additional protection from oxidative stress due to down-regulation of iron acquisition from transferrin and increased glutamate for glutathione synthesis.	Iron	99-103	transferrin	Homo sapiens	121-132
22465143-1	2012	Haptoglobin (Hp) is a hemoglobin (Hb) binding protein whose major function is to prevent heme-iron mediated oxidation.	Iron	94-98	haptoglobin	Homo sapiens	0-11
22514282-6	2012	The N-terminal thymidine hydroxylase domain of JBP1 is sufficient for full activity and mutation of residues involved in coordinating Fe(2+) inhibit iron binding and thymidine hydroxylation.	Iron	149-153	protein arginine methyltransferase 5	Homo sapiens	47-51
22555879-7	2012	The shoot and root growth of atx1 and cchatx1 but not cch was specifically hypersensitive to excess Cu but not excess iron, zinc, or cadmium.	Iron	118-122	copper chaperone	Arabidopsis thaliana	38-41
22211566-1	2012	The relationships between erythropoietin (EPO), iron, and erythropoiesis and the presence of iron-restricted erythropoiesis have important implications in anemia management.	Iron	93-97	erythropoietin	Homo sapiens	26-40
22211566-1	2012	The relationships between erythropoietin (EPO), iron, and erythropoiesis and the presence of iron-restricted erythropoiesis have important implications in anemia management.	Iron	93-97	erythropoietin	Homo sapiens	42-45
22211566-4	2012	Functional iron deficiency occurs in patients with significant EPO-mediated erythropoiesis or therapy with erythropoiesis-stimulating agents, even when storage iron is present.	Iron	11-15	erythropoietin	Homo sapiens	63-66
22683637-4	2012	The upregulation of CTR2 induced by iron depletion was abrogated by the genetic deletion of either Mac1p or iron-sensing transcription factor Aft1p.	Iron	36-40	Mac1p	Saccharomyces cerevisiae S288C	99-104
22658601-6	2012	We further show that BTBD9 regulates brain dopamine levels in flies and controls iron homeostasis through the iron regulatory protein-2 in human cell lines.	Iron	81-85	iron responsive element binding protein 2	Homo sapiens	110-135
24198494-3	2012	Different nanostructures of iron-platinum alloy and chemically disordered iron-platinum L10 phase were obtained without annealing.	Iron	74-78	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	88-91
22689995-0	2012	Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold.	Iron	71-75	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	30-34
22689995-10	2012	Our results suggest that modulation of the degradation of Isu by the Pim1 protease is a regulatory mechanism serving to rapidly help balance the cell"s need for critical iron-requiring processes under changing environmental conditions.	Iron	170-174	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	69-73
22432601-1	2012	Geminate recombination of the methionine ligand to the heme iron in ferrous cytochrome c protein following photodissociation displays rich kinetics.	Iron	60-64	cytochrome c, somatic	Homo sapiens	76-88
22633452-0	2012	Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2.	Iron	0-4	poly(rC) binding protein 2	Homo sapiens	72-97
22362375-7	2012	The ability of the dithiocarbazate Schiff base ligands to mobilise Fe from cells and also to prevent Fe uptake from transferrin was examined and all ligands were effective in chelating intracellular Fe relative to known controls such as the clinically important Fe chelator desferrioxamine.	Iron	101-103	transferrin	Homo sapiens	116-127
22362375-7	2012	The ability of the dithiocarbazate Schiff base ligands to mobilise Fe from cells and also to prevent Fe uptake from transferrin was examined and all ligands were effective in chelating intracellular Fe relative to known controls such as the clinically important Fe chelator desferrioxamine.	Iron	101-103	transferrin	Homo sapiens	116-127
22450660-4	2012	In contrast to amino acid neurotransmitters, catecholamine neurotransmitters, L-DOPA, and curcumin prevent significant iron-mediated DNA damage (IC(50) values of 3.2 to 18 muM) and are electrochemically active.	Iron	119-123	latexin	Homo sapiens	172-175
22633452-5	2012	We show that cytosolic iron could regulate the activity of the miRNA pathway through poly(C)-binding protein 2 (PCBP2).	Iron	23-27	poly(rC) binding protein 2	Homo sapiens	85-110
22633452-5	2012	We show that cytosolic iron could regulate the activity of the miRNA pathway through poly(C)-binding protein 2 (PCBP2).	Iron	23-27	poly(rC) binding protein 2	Homo sapiens	112-117
22633452-7	2012	Cytosolic iron could modulate the association between PCBP2 and Dicer, as well as the multimerization of PCBP2 and its ability to bind to miRNA precursors, which can alter the processing of miRNA precursors.	Iron	10-14	poly(rC) binding protein 2	Homo sapiens	54-59
22633452-7	2012	Cytosolic iron could modulate the association between PCBP2 and Dicer, as well as the multimerization of PCBP2 and its ability to bind to miRNA precursors, which can alter the processing of miRNA precursors.	Iron	10-14	poly(rC) binding protein 2	Homo sapiens	105-110
22487307-0	2012	A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2.	Iron	75-79	electron carrier DRE2	Saccharomyces cerevisiae S288C	105-109
22683786-6	2012	The putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein.	Iron	152-156	cytosolic iron-sulfur assembly component 2A	Homo sapiens	92-98
22292499-9	2012	This suggests that upon iron depletion, cells prefer to use GAPDH to acquire lactoferrin.	Iron	24-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	60-65
22435664-6	2012	These findings indicate that oxidative stress caused by a SOD1 deficiency probably enhances the phosphorylation of and the conversion of IRP1 to the IRE-binding form, which may accelerate the reabsorption of iron by renal tubular cells.	Iron	208-212	superoxide dismutase 1, soluble	Mus musculus	58-62
22332888-1	2012	Bacteria that inhabit the mucosal surfaces of the respiratory and genitourinary tracts of mammals encounter an iron-deficient environment because of iron sequestration by the host iron-binding proteins transferrin and lactoferrin.	Iron	111-115	transferrin	Homo sapiens	202-213
22332888-1	2012	Bacteria that inhabit the mucosal surfaces of the respiratory and genitourinary tracts of mammals encounter an iron-deficient environment because of iron sequestration by the host iron-binding proteins transferrin and lactoferrin.	Iron	129-133	transferrin	Homo sapiens	202-213
22332888-1	2012	Bacteria that inhabit the mucosal surfaces of the respiratory and genitourinary tracts of mammals encounter an iron-deficient environment because of iron sequestration by the host iron-binding proteins transferrin and lactoferrin.	Iron	129-133	transferrin	Homo sapiens	202-213
22332905-6	2012	Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling.	Iron	103-107	AKT serine/threonine kinase 1	Homo sapiens	165-168
22332905-6	2012	Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling.	Iron	103-107	mitogen-activated protein kinase 3	Homo sapiens	207-213
22332905-6	2012	Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling.	Iron	124-128	AKT serine/threonine kinase 1	Homo sapiens	165-168
22332905-6	2012	Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling.	Iron	124-128	mitogen-activated protein kinase 3	Homo sapiens	207-213
21999968-0	2012	Early-onset neurodegeneration with brain iron accumulation due to PANK2 mutation.	Iron	41-45	pantothenate kinase 2	Homo sapiens	66-71
21999968-3	2012	AIMS: To describe clinical and MRI findings of a boy with early-onset neurodegeneration with brain iron accumulation due to PANK2 mutation.	Iron	99-103	pantothenate kinase 2	Homo sapiens	124-129
22435664-5	2012	In SOD1 KO mice kidneys, protein levels of iron transporters, the iron-responsive element (IRE)-binding activity of IRP1 and the levels of phosphorylation of IRP1 are all increased.	Iron	43-47	superoxide dismutase 1, soluble	Mus musculus	3-7
22487307-1	2012	Yeast Dre2 is an essential Fe-S cluster-containing protein that has been implicated in cytosolic Fe-S protein biogenesis and in cell death regulation in response to oxidative stress.	Iron	27-31	electron carrier DRE2	Saccharomyces cerevisiae S288C	6-10
22487307-5	2012	The highly conserved C-terminus of Dre2, containing two Fe-S clusters, influences the flexibility of the N-terminal domain.	Iron	56-60	electron carrier DRE2	Saccharomyces cerevisiae S288C	35-39
22908694-3	2012	OBJECTIVE: To evaluate the kinetics of circulating concentrations of plasma iron and non-transferrin-bound iron (NTBI) in response to oral iron administration in healthy adults.	Iron	107-111	transferrin	Homo sapiens	89-100
22908694-3	2012	OBJECTIVE: To evaluate the kinetics of circulating concentrations of plasma iron and non-transferrin-bound iron (NTBI) in response to oral iron administration in healthy adults.	Iron	107-111	transferrin	Homo sapiens	89-100
21926164-1	2012	Hepcidin has been found to be the key regulator of iron metabolism that leads to hypoferremia during inflammation.	Iron	51-55	hepcidin	Equus caballus	0-8
22180427-0	2012	Timed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response.	Iron	28-32	transferrin	Homo sapiens	10-21
22180427-0	2012	Timed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response.	Iron	79-83	transferrin	Homo sapiens	10-21
22180427-1	2012	BACKGROUND: Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis.	Iron	41-45	transferrin	Homo sapiens	23-34
22180427-1	2012	BACKGROUND: Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis.	Iron	77-81	transferrin	Homo sapiens	23-34
22180427-1	2012	BACKGROUND: Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis.	Iron	77-81	transferrin	Homo sapiens	23-34
22180427-6	2012	Absolute or relative non-transferrin bound iron levels were related to transfusional iron loading rates, liver iron concentration, 24-hour urine iron and response to chelation therapy over the subsequent year.	Iron	43-47	transferrin	Homo sapiens	25-36
22180427-6	2012	Absolute or relative non-transferrin bound iron levels were related to transfusional iron loading rates, liver iron concentration, 24-hour urine iron and response to chelation therapy over the subsequent year.	Iron	85-89	transferrin	Homo sapiens	25-36
22180427-6	2012	Absolute or relative non-transferrin bound iron levels were related to transfusional iron loading rates, liver iron concentration, 24-hour urine iron and response to chelation therapy over the subsequent year.	Iron	85-89	transferrin	Homo sapiens	25-36
22180427-6	2012	Absolute or relative non-transferrin bound iron levels were related to transfusional iron loading rates, liver iron concentration, 24-hour urine iron and response to chelation therapy over the subsequent year.	Iron	85-89	transferrin	Homo sapiens	25-36
22180427-7	2012	RESULTS: Changes in non-transferrin bound iron at week 1 were correlated positively with baseline liver iron, and inversely with transfusional iron loading rates, with deferiprone-containing regimens but not with desferrioxamine monotherapy.	Iron	42-46	transferrin	Homo sapiens	24-35
22180427-7	2012	RESULTS: Changes in non-transferrin bound iron at week 1 were correlated positively with baseline liver iron, and inversely with transfusional iron loading rates, with deferiprone-containing regimens but not with desferrioxamine monotherapy.	Iron	104-108	transferrin	Homo sapiens	24-35
22180427-7	2012	RESULTS: Changes in non-transferrin bound iron at week 1 were correlated positively with baseline liver iron, and inversely with transfusional iron loading rates, with deferiprone-containing regimens but not with desferrioxamine monotherapy.	Iron	104-108	transferrin	Homo sapiens	24-35
22180427-8	2012	Changes in week 1 non-transferrin bound iron were also directly proportional to the plasma concentration of deferiprone-iron complexes and correlated significantly with urine iron excretion and with changes in liver iron concentration over the next 12 months.	Iron	40-44	transferrin	Homo sapiens	22-33
22180427-8	2012	Changes in week 1 non-transferrin bound iron were also directly proportional to the plasma concentration of deferiprone-iron complexes and correlated significantly with urine iron excretion and with changes in liver iron concentration over the next 12 months.	Iron	120-124	transferrin	Homo sapiens	22-33
22180427-8	2012	Changes in week 1 non-transferrin bound iron were also directly proportional to the plasma concentration of deferiprone-iron complexes and correlated significantly with urine iron excretion and with changes in liver iron concentration over the next 12 months.	Iron	120-124	transferrin	Homo sapiens	22-33
22180427-8	2012	Changes in week 1 non-transferrin bound iron were also directly proportional to the plasma concentration of deferiprone-iron complexes and correlated significantly with urine iron excretion and with changes in liver iron concentration over the next 12 months.	Iron	120-124	transferrin	Homo sapiens	22-33
22180427-9	2012	CONCLUSIONS: The widely used assay chosen for this study detects both endogenous non-transferrin bound iron and the iron complexes of deferiprone.	Iron	103-107	transferrin	Homo sapiens	85-96
22228039-0	2012	Interactions of phytate and myo-inositol phosphate esters (IP1-5) including IP5 isomers with dietary protein and iron and inhibition of pepsin.	Iron	113-117	interferon induced transmembrane protein 3	Homo sapiens	59-64
21455763-1	2012	Transferrin (Tf) is a glycoprotein responsible for iron transport in the human body.	Iron	51-55	transferrin	Homo sapiens	0-11
22322235-4	2012	Under the resulting conditions of iron overload, the tissue pattern of extrahepatic siderosis is determined by the normal expression of proteins involved in the import of non-transferrin-bound iron and the export of cellular iron.	Iron	34-38	transferrin	Homo sapiens	175-186
22454108-0	2012	Reductive activation of the heme iron-nitrosyl intermediate in the reaction mechanism of cytochrome c nitrite reductase: a theoretical study.	Iron	33-37	cytochrome c, somatic	Homo sapiens	89-101
22322235-9	2012	CONCLUSIONS: Excess non-transferrin-bound iron in gestational alloimmune liver disease may result from fetal liver injury that causes reduced synthesis of key iron regulatory and transport proteins.	Iron	42-46	transferrin	Homo sapiens	24-35
22322235-4	2012	Under the resulting conditions of iron overload, the tissue pattern of extrahepatic siderosis is determined by the normal expression of proteins involved in the import of non-transferrin-bound iron and the export of cellular iron.	Iron	193-197	transferrin	Homo sapiens	175-186
22322235-9	2012	CONCLUSIONS: Excess non-transferrin-bound iron in gestational alloimmune liver disease may result from fetal liver injury that causes reduced synthesis of key iron regulatory and transport proteins.	Iron	159-163	transferrin	Homo sapiens	24-35
22322235-10	2012	Whereas, the pattern of extrahepatic siderosis appears to be determined by the normal capacity of various tissues to import non-transferrin-bound iron and not export cellular iron.	Iron	146-150	transferrin	Homo sapiens	128-139
22322235-4	2012	Under the resulting conditions of iron overload, the tissue pattern of extrahepatic siderosis is determined by the normal expression of proteins involved in the import of non-transferrin-bound iron and the export of cellular iron.	Iron	193-197	transferrin	Homo sapiens	175-186
22685165-3	2012	In one pathway, MSD3 is upregulated at the transcriptional level up to 10(3)-fold in response to Fe limitation, leading to synthesis of a previously undiscovered plastid-specific MnSOD whose identity we validated immunochemically.	Iron	97-99	uncharacterized protein	Chlamydomonas reinhardtii	16-20
22575541-5	2012	This transporter acts in partnership with the ferroxidase hephaestin that oxidizes exported ferrous iron to facilitate its binding to plasma transferrin.	Iron	100-104	transferrin	Homo sapiens	141-152
22657586-10	2012	There was a significant negative correlation between lipophilic serum vitamin concentrations and body fat, as well as between iron and C-reactive protein.	Iron	126-130	C-reactive protein	Homo sapiens	135-153
22647488-1	2012	In patients with metabolic syndrome, body iron overload exacerbates insulin resistance, impairment of glucose metabolism, endothelium dysfunction and coronary artery responses.	Iron	42-46	insulin	Homo sapiens	68-75
22469696-3	2012	The current study aimed to compare expression and localization of iron transport protein ferroportin-1 (Fpn-1) and of other iron import proteins after experimental tissue damage induced by injecting turpentine oil in the hind limbs of rats and mice.	Iron	66-70	solute carrier family 40 member 1	Rattus norvegicus	89-102
22469696-3	2012	The current study aimed to compare expression and localization of iron transport protein ferroportin-1 (Fpn-1) and of other iron import proteins after experimental tissue damage induced by injecting turpentine oil in the hind limbs of rats and mice.	Iron	66-70	solute carrier family 40 member 1	Rattus norvegicus	104-109
22661928-4	2012	Iron is believed to reach the brain through receptor-mediated endocytosis of iron-bound transferrin by the brain barriers, the blood-cerebrospinal fluid (CSF) barrier, formed by the choroid plexus (CP) epithelial cells and the blood-brain barrier (BBB) formed by the endothelial cells of the brain capillaries.	Iron	0-4	transferrin	Homo sapiens	88-99
22661928-4	2012	Iron is believed to reach the brain through receptor-mediated endocytosis of iron-bound transferrin by the brain barriers, the blood-cerebrospinal fluid (CSF) barrier, formed by the choroid plexus (CP) epithelial cells and the blood-brain barrier (BBB) formed by the endothelial cells of the brain capillaries.	Iron	77-81	transferrin	Homo sapiens	88-99
22453918-0	2012	The iron chelators Dp44mT and DFO inhibit TGF-beta-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).	Iron	4-8	transforming growth factor beta 1	Homo sapiens	42-50
22563719-2	2012	Single-crystal X-ray studies reveal that three eight-coordinated Dy(III) centers in a square antiprismatic coordination environment are connecting to a central octahedral trivalent Fe or Co ion forming a propeller-type complex.	Iron	181-183	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	68-71
22453918-3	2012	NDRG1 expression is markedly increased after chelator-mediated iron depletion via hypoxia-inducible factor 1alpha-dependent and independent pathways (Le, N. T. and Richardson, D. R. (2004) Blood 104, 2967-2975).	Iron	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-113
22542446-0	2012	H2O2 signals via iron induction of VL30 retrotransposition correlated with cytotoxicity.	Iron	17-21	RIKEN cDNA A130040M12 gene	Mus musculus	35-39
22434362-0	2012	Studies of iron(II) and iron(III) complexes with fac-N2O, cis-N2O2 and N2O3 donor ligands: models for the 2-His 1-carboxylate motif of non-heme iron monooxygenases.	Iron	11-15	FA complementation group C	Homo sapiens	49-52
22434362-0	2012	Studies of iron(II) and iron(III) complexes with fac-N2O, cis-N2O2 and N2O3 donor ligands: models for the 2-His 1-carboxylate motif of non-heme iron monooxygenases.	Iron	24-28	FA complementation group C	Homo sapiens	49-52
22628316-1	2012	The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in this way iron plasma levels.	Iron	139-143	transmembrane serine protease 6	Homo sapiens	42-54
22503983-9	2012	In polarized cells, we found that both apical (as FeSO(4)) and basolateral iron (as the ratio of apo-transferrin to holo-transferrin) affect mobilization of hephaestin from the supra-nuclear compartment.	Iron	75-79	transferrin	Homo sapiens	101-112
22503983-9	2012	In polarized cells, we found that both apical (as FeSO(4)) and basolateral iron (as the ratio of apo-transferrin to holo-transferrin) affect mobilization of hephaestin from the supra-nuclear compartment.	Iron	75-79	transferrin	Homo sapiens	121-132
22365930-2	2012	The latter occurs by insertion into cytochrome c of an acyl chain, resulting in the dissociation of the axial Met-80 heme-iron ligand.	Iron	122-126	cytochrome c, somatic	Homo sapiens	36-48
22628316-1	2012	The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in this way iron plasma levels.	Iron	139-143	transmembrane serine protease 6	Homo sapiens	56-63
22628316-1	2012	The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in this way iron plasma levels.	Iron	183-187	transmembrane serine protease 6	Homo sapiens	42-54
22628316-1	2012	The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in this way iron plasma levels.	Iron	183-187	transmembrane serine protease 6	Homo sapiens	56-63
22628316-2	2012	Matriptase-2 is up-regulated under hypoxic conditions, providing a new link between hypoxia signaling and iron homeostasis.	Iron	106-110	transmembrane serine protease 6	Homo sapiens	0-12
22298416-0	2012	Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-alpha and TGF-beta1.	Iron	0-4	tumor necrosis factor	Mus musculus	76-85
22180428-1	2012	BACKGROUND: In transfusional siderosis, the iron binding capacity of plasma transferrin is often surpassed, with concomitant generation of non-transferrin-bound iron.	Iron	44-48	transferrin	Homo sapiens	76-87
22180428-2	2012	Although implicated in tissue siderosis, non-transferrin-bound iron modes of cell ingress remain undefined, largely because of its variable composition and association with macromolecules.	Iron	63-67	transferrin	Homo sapiens	45-56
22180428-4	2012	DESIGN AND METHODS: Fluorescence microscopy and flow cytometry served as analytical tools for tracing non-transferrin-bound iron entry into endosomes with the redox-reactive macromolecular probe Oxyburst-Green and into the cytosol with cell-laden calcein green and calcein blue.	Iron	124-128	transferrin	Homo sapiens	106-117
22298416-5	2012	Here we report that the proinflammatory cytokine TNF-alpha, and the anti-inflammatory cytokine TGF-beta1 affect iron homeostasis in astrocytes and microglia in distinct ways.	Iron	112-116	tumor necrosis factor	Mus musculus	49-58
22180428-5	2012	Non-transferrin-bound iron-containing media were from sera of polytransfused thalassemia major patients and model iron substances detected in thalassemia major sera; cell models were cultured macrophages, and cardiac myoblasts and myocytes.	Iron	22-26	transferrin	Homo sapiens	4-15
22180428-6	2012	RESULTS: Exposure of cells to ferric citrate together with albumin, or to non-transferrin-bound iron-containing sera from thalassemia major patients caused an increase in labile iron content of endosomes and cytosol in macrophages and cardiac cells.	Iron	96-100	transferrin	Homo sapiens	78-89
22298416-10	2012	In particular, TNF-alpha caused an increase in iron uptake and retention by both astrocytes and microglia, while TGF-beta1 promoted iron efflux from astrocytes but caused iron retention in microglia.	Iron	47-51	tumor necrosis factor	Mus musculus	15-24
22180428-6	2012	RESULTS: Exposure of cells to ferric citrate together with albumin, or to non-transferrin-bound iron-containing sera from thalassemia major patients caused an increase in labile iron content of endosomes and cytosol in macrophages and cardiac cells.	Iron	178-182	transferrin	Homo sapiens	78-89
22180428-7	2012	This increase was more striking in macrophages, but in both cell types was largely reduced by co-exposure to non-transferrin-bound iron-containing media with non-penetrating iron chelators or apo-transferrin, or by treatment with inhibitors of endocytosis.	Iron	131-135	transferrin	Homo sapiens	113-124
22180428-8	2012	Endosomal iron accumulation traced with calcein-green was proportional to input non-transferrin-bound iron levels (r(2) = 0.61) and also preventable by pre-chelation.	Iron	10-14	transferrin	Homo sapiens	84-95
22180428-8	2012	Endosomal iron accumulation traced with calcein-green was proportional to input non-transferrin-bound iron levels (r(2) = 0.61) and also preventable by pre-chelation.	Iron	102-106	transferrin	Homo sapiens	84-95
22180428-9	2012	CONCLUSIONS: Our studies indicate that macromolecule-associated non-transferrin-bound iron can initially gain access into various cells via endocytic pathways, followed by iron translocation to the cytosol.	Iron	86-90	transferrin	Homo sapiens	68-79
22180428-9	2012	CONCLUSIONS: Our studies indicate that macromolecule-associated non-transferrin-bound iron can initially gain access into various cells via endocytic pathways, followed by iron translocation to the cytosol.	Iron	172-176	transferrin	Homo sapiens	68-79
22180428-10	2012	Endocytic uptake of plasma non-transferrin-bound iron is a possible mechanism that can contribute to iron loading of cell types engaged in bulk/adsorptive endocytosis, highlighting the importance of its prevention by iron chelation.	Iron	49-53	transferrin	Homo sapiens	31-42
22180428-10	2012	Endocytic uptake of plasma non-transferrin-bound iron is a possible mechanism that can contribute to iron loading of cell types engaged in bulk/adsorptive endocytosis, highlighting the importance of its prevention by iron chelation.	Iron	101-105	transferrin	Homo sapiens	31-42
22180428-10	2012	Endocytic uptake of plasma non-transferrin-bound iron is a possible mechanism that can contribute to iron loading of cell types engaged in bulk/adsorptive endocytosis, highlighting the importance of its prevention by iron chelation.	Iron	101-105	transferrin	Homo sapiens	31-42
22057405-6	2012	Both TCS and MRI studies in PKAN patients are in accordance with the pathological findings that accumulation of iron, even in advanced cases, is restricted to the GP and SN, suggesting selective involvement of these structures.	Iron	112-116	pantothenate kinase 2	Homo sapiens	28-32
22459167-9	2012	These in vitro data suggest that, in principle, elevated phosphate concentrations can influence the ability of apo-transferrin to bind iron, depending on the oxidation state of the iron.	Iron	135-139	transferrin	Homo sapiens	115-126
22459167-9	2012	These in vitro data suggest that, in principle, elevated phosphate concentrations can influence the ability of apo-transferrin to bind iron, depending on the oxidation state of the iron.	Iron	181-185	transferrin	Homo sapiens	115-126
22323359-5	2012	TMPRSS6 polymorphisms were also associated with lower serum iron (SI) and hemoglobin levels, consistent with their associations to increased iron deficiency and anemia risk.	Iron	60-64	transmembrane serine protease 6	Homo sapiens	0-7
22323359-7	2012	Our findings suggest that TF, TFR2 and TMPRSS6 polymorphisms are significantly associated with decreased iron status, but only variants in TMPRSS6 are genetic risk factors for iron deficiency and IDA.	Iron	105-109	transmembrane serine protease 6	Homo sapiens	39-46
22570295-2	2012	However, this method of iron repletion was chiefly developed for patients with large iron deficits, such as those with pregnancy-induced anemia, chronic bleeding disorders, and absolute iron-deficiency anemia (serum ferritin &lt; 30 ng/mL, transferrin saturation &lt; 15%) who were unable to receive frequent small doses of intravenous iron.	Iron	24-28	transferrin	Homo sapiens	240-251
22389496-1	2012	Bacteria use tight-binding, ferric-specific chelators called siderophores to acquire iron from the environment and from the host during infection; animals use proteins such as transferrin and ferritin to transport and store iron.	Iron	85-89	transferrin	Homo sapiens	176-187
23087549-1	2012	Resistance to recombinant erythropoietin (rEPO) in hemodialysis patients may be due to inadequate iron recruitment and defect in iron use.	Iron	98-102	erythropoietin	Homo sapiens	26-40
23087549-1	2012	Resistance to recombinant erythropoietin (rEPO) in hemodialysis patients may be due to inadequate iron recruitment and defect in iron use.	Iron	129-133	erythropoietin	Homo sapiens	26-40
22589187-6	2012	Lower concentrations of iron facilitated hepatitis B e-antigen (HBeAg) secretion.	Iron	24-28	capsid protein;pre-capsid protein	Hepatitis B virus	41-70
22589187-11	2012	Interestingly, nuclear import of Nuclear factor kappa B (NFkappaB) and its activity were found to be affected by the decreased Nup153 in iron stimulated HepG2.2.15 cells.	Iron	137-141	nuclear factor kappa B subunit 1	Homo sapiens	33-55
22589187-11	2012	Interestingly, nuclear import of Nuclear factor kappa B (NFkappaB) and its activity were found to be affected by the decreased Nup153 in iron stimulated HepG2.2.15 cells.	Iron	137-141	nuclear factor kappa B subunit 1	Homo sapiens	57-65
22445852-5	2012	Treatment with either an iron chelator (deferoxamine) or over-expression of ftn-1, encoding the iron sequestering protein ferritin, increased resistance to t-BOOH and, in the latter case, reduced protein oxidation, but did not increase lifespan.	Iron	96-100	Ferritin	Caenorhabditis elegans	122-130
22275523-7	2012	Functional classification analysis showed that OxyR controls a core regulon of oxidative stress defensive genes, and other genes involved in regulation of iron homeostasis (pvdS), quorum-sensing (rsaL), protein synthesis (rpsL) and oxidative phosphorylation (cyoA and snr1).	Iron	155-159	transcriptional regulator	Pseudomonas aeruginosa PAO1	47-51
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	33-37	interleukin 6	Rattus norvegicus	0-13
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	33-37	interleukin 6	Rattus norvegicus	15-19
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	33-37	hepcidin antimicrobial peptide	Rattus norvegicus	46-54
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	69-73	interleukin 6	Rattus norvegicus	0-13
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	69-73	interleukin 6	Rattus norvegicus	15-19
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	46-54
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	69-73	interleukin 6	Rattus norvegicus	0-13
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	69-73	interleukin 6	Rattus norvegicus	15-19
22364558-2	2012	Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	46-54
22364558-3	2012	The expressions of hepcidin and the iron-regulatory pathway of hepcidin gene expression during the late phase of liver regeneration are unknown.	Iron	36-40	hepcidin antimicrobial peptide	Rattus norvegicus	63-71
22364558-4	2012	AIM: To characterize the expression pattern of hepcidin and the iron-sensing pathway of hepcidin regulation during liver regeneration.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	88-96
22364558-12	2012	CONCLUSIONS: Hepcidin gene expression peaks during the acute-phase response, but a sustained down-regulation of the iron-sensing pathway of hepcidin regulation gradually reduces hepcidin gene expression until regeneration is complete, thereby promoting iron mobilization to the regenerating liver.	Iron	116-120	hepcidin antimicrobial peptide	Rattus norvegicus	140-148
22364558-12	2012	CONCLUSIONS: Hepcidin gene expression peaks during the acute-phase response, but a sustained down-regulation of the iron-sensing pathway of hepcidin regulation gradually reduces hepcidin gene expression until regeneration is complete, thereby promoting iron mobilization to the regenerating liver.	Iron	116-120	hepcidin antimicrobial peptide	Rattus norvegicus	178-186
22364558-12	2012	CONCLUSIONS: Hepcidin gene expression peaks during the acute-phase response, but a sustained down-regulation of the iron-sensing pathway of hepcidin regulation gradually reduces hepcidin gene expression until regeneration is complete, thereby promoting iron mobilization to the regenerating liver.	Iron	253-257	hepcidin antimicrobial peptide	Rattus norvegicus	140-148
22389496-1	2012	Bacteria use tight-binding, ferric-specific chelators called siderophores to acquire iron from the environment and from the host during infection; animals use proteins such as transferrin and ferritin to transport and store iron.	Iron	102-106	transferrin	Homo sapiens	176-187
22287607-3	2012	Because HO-1 is involved in the response to oxidative stress produced by hyperoxia and is critical for cellular heme and iron homeostasis, it could play a protective role in BPD.	Iron	121-125	heme oxygenase 1	Mus musculus	8-12
22435663-3	2012	The most abundant classes of iron-containing particles were iron oxide fly ash, mineral dust, NaCl-containing agglomerates (likely from road salt), and Ca-S containing agglomerates (likely from slag, a byproduct of steel production, or gypsum in road salt).	Iron	29-33	Chromosome segregation 1	Drosophila melanogaster	152-156
22287607-9	2012	Thus the protective mechanisms elicited by HO-1 overexpression primarily preserve vascular growth and barrier function through iron-independent, antioxidant, and anti-inflammatory pathways.	Iron	127-131	heme oxygenase 1	Mus musculus	43-47
22492618-0	2012	The structural basis of iron sensing by the human F-box protein FBXL5.	Iron	24-28	F-box and leucine rich repeat protein 5	Homo sapiens	64-69
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	ferritin heavy chain 1	Rattus norvegicus	204-224
22367199-11	2012	Yeast Jjj3, a functional ortholog of human Dph4 also shows a similar iron-binding property, indicating the conserved nature of iron sequestration across species.	Iron	69-73	Jjj3p	Saccharomyces cerevisiae S288C	6-10
22367199-11	2012	Yeast Jjj3, a functional ortholog of human Dph4 also shows a similar iron-binding property, indicating the conserved nature of iron sequestration across species.	Iron	127-131	Jjj3p	Saccharomyces cerevisiae S288C	6-10
22232660-2	2012	Specific genetic markers have been previously identified that influence levels of transferrin, the protein that transports iron throughout the body, in the blood and brain.	Iron	123-127	transferrin	Homo sapiens	82-93
22492039-5	2012	Cell culture work showed that lack of iron reduces the ability of microglia to express cytokines (TNF-alpha and IL-1beta) involved in remyelination.	Iron	38-42	tumor necrosis factor	Mus musculus	98-107
22492039-5	2012	Cell culture work showed that lack of iron reduces the ability of microglia to express cytokines (TNF-alpha and IL-1beta) involved in remyelination.	Iron	38-42	interleukin 1 beta	Mus musculus	112-120
22310496-0	2012	Spectroscopic characterization of (57)Fe-enriched cytochrome c.	Iron	38-40	cytochrome c, somatic	Homo sapiens	50-62
22310496-1	2012	Investigation of the heme iron dynamics in cytochrome c with Mossbauer spectroscopy and especially nuclear resonance vibrational spectroscopy requires the replacement of the natural abundant heme iron with the (57)Fe isotope.	Iron	26-30	cytochrome c, somatic	Homo sapiens	43-55
22310496-1	2012	Investigation of the heme iron dynamics in cytochrome c with Mossbauer spectroscopy and especially nuclear resonance vibrational spectroscopy requires the replacement of the natural abundant heme iron with the (57)Fe isotope.	Iron	196-200	cytochrome c, somatic	Homo sapiens	43-55
22310496-1	2012	Investigation of the heme iron dynamics in cytochrome c with Mossbauer spectroscopy and especially nuclear resonance vibrational spectroscopy requires the replacement of the natural abundant heme iron with the (57)Fe isotope.	Iron	214-216	cytochrome c, somatic	Homo sapiens	43-55
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	ferritin heavy chain 1	Rattus norvegicus	226-229
22198321-3	2012	There is also evidence showing that a series of genes with important functions in iron metabolism, including transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1), are regulated by HIF-1alpha in response to hypoxia in extra-neural organs or cells.	Iron	82-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-205
22234787-6	2012	RESULTS: The angiogenic to antiangiogenic ratio [PlGF/(sFlt-1 x sEng)] was positively related to intake of vitamin D (r = 0.24), vitamin B(2) (r = 0.25), B(12) (r = 0.20), dietary folate equivalents (r = 0.19), iron (r = 0.19), and zinc (r = 0.19) and negatively related to transfats (r = -0.24).	Iron	211-215	placental growth factor	Homo sapiens	49-53
22198321-5	2012	We herein demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (ferroportin1) proteins, and thus increase tansferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release in astrocytes.	Iron	229-233	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
22198321-9	2012	We also demonstrated that ferroportin1 expression was significantly affected by HIF-1alpha in astrocytes, implying that the gene encoding this iron efflux protein might be a hypoxia-inducible one.	Iron	143-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
22198321-5	2012	We herein demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (ferroportin1) proteins, and thus increase tansferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release in astrocytes.	Iron	238-240	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
22198321-5	2012	We herein demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (ferroportin1) proteins, and thus increase tansferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release in astrocytes.	Iron	229-233	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
22198321-5	2012	We herein demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (ferroportin1) proteins, and thus increase tansferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release in astrocytes.	Iron	229-233	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
22181812-0	2012	Iron facilitator LS081 reduces hypoxia-inducible factor-1alpha protein and functions as anticancer agent in hepatocellular carcinoma.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-62
22631035-4	2012	Preclinical studies suggest that Jak inhibitors, hepcidin agonists, and exogenous transferrin may help to restore normal erythropoiesis and iron metabolism and reduce splenomegaly; however, further research is needed.	Iron	140-144	transferrin	Homo sapiens	82-93
22181812-3	2012	In normoxic conditions, HIF-1alpha is hydroxylated by oxygen-dependent prolyl-hydroxylases, which require ferrous iron for its activity.	Iron	106-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
22181812-7	2012	In the present study, we aimed to inhibit the expression of HIF-1alpha protein and growth of hepatocellular carcinoma by using the iron-facilitating activity of LS081.	Iron	131-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
22181812-11	2012	These results indicate that the iron-facilitating activity of LS081 inhibits HIF-1alpha expression through prolyl-hydroxylation of HIF-1alpha and might have a therapeutic effect in the treatment of hepatocellular carcinoma.	Iron	32-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
22181812-11	2012	These results indicate that the iron-facilitating activity of LS081 inhibits HIF-1alpha expression through prolyl-hydroxylation of HIF-1alpha and might have a therapeutic effect in the treatment of hepatocellular carcinoma.	Iron	32-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
22366383-1	2012	Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-beta (Abeta) plaques within the brain of Alzheimer"s disease (AD).	Iron	47-49	amyloid beta precursor protein	Homo sapiens	63-75
22348897-13	2012	Iron reduced the number of hospitalizations and C-reactive protein levels, and increased the 6MWD and mean ejection fraction.	Iron	0-4	C-reactive protein	Homo sapiens	48-66
22366383-1	2012	Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-beta (Abeta) plaques within the brain of Alzheimer"s disease (AD).	Iron	47-49	amyloid beta precursor protein	Homo sapiens	77-82
22468098-9	2012	Consequently, CD34(+) cells should be transplanted as many as possible to prevent the sustained iron overload after tandem HDCT/autoSCT and consequent adverse effects.	Iron	96-100	CD34 molecule	Homo sapiens	14-18
23029753-1	2012	Neurodegeneration with brain iron accumulation is a group of disorders, the commonest of which is PKAN (Pantothenate kinase associated neurodegeneration).	Iron	29-33	pantothenate kinase 2	Homo sapiens	98-102
23029753-1	2012	Neurodegeneration with brain iron accumulation is a group of disorders, the commonest of which is PKAN (Pantothenate kinase associated neurodegeneration).	Iron	29-33	pantothenate kinase 2	Homo sapiens	104-152
22127788-6	2012	CONCLUSION: Our findings support the hypothesis that the absence of the "tiger"s eye" in PKAN might be secondary, probably caused by an increased accumulation of iron.	Iron	162-166	pantothenate kinase 2	Homo sapiens	89-93
22399131-0	2012	Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport.	Iron	12-14	transferrin	Homo sapiens	72-83
21166995-4	2012	In anaemic children, 7.0% of males and 15.0% of females were iron deficient (serum ferritin &lt; 15.0 microg L-1).	Iron	61-65	immunoglobulin kappa variable 1-16	Homo sapiens	109-112
22399131-1	2012	Neisseria gonorrhoeae is an obligate pathogen that hijacks iron from the human iron transport protein, holo-transferrin (Fe(2)-Tf), by expressing TonB-dependent outer membrane receptor proteins, TbpA and TbpB.	Iron	59-63	transferrin	Homo sapiens	108-119
22253436-0	2012	Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).	Iron	45-49	F-box and leucine rich repeat protein 5	Homo sapiens	130-135
22266337-2	2012	Neurodegeneration with brain iron accumulation (NBIA) involves several genetic disorders, two of which, aceruloplasminemia and neuroferritinopathy, are caused by mutations in genes directly involved in iron metabolic pathway, and others, such as pantothenate-kinase 2, phospholipase-A2 and fatty acid 2-hydroxylase associated neurodegeneration, are caused by mutations in genes coding for proteins involved in phospholipid metabolism.	Iron	29-33	phospholipase A2 group IB	Homo sapiens	269-285
23543250-7	2012	Iron supplementation should be safe in the absence of iron metabolism disorders, provided that transferrin saturation and ferritin levels are monitored pre-and post-treatment.	Iron	0-4	transferrin	Homo sapiens	95-106
22364386-0	2012	Protonation and anion binding control the kinetics of iron release from human transferrin.	Iron	54-58	transferrin	Homo sapiens	78-89
22364386-1	2012	Iron release in vitro from human serum diferric transferrin (hFe(2)Tf) in acidic media (4.2 &lt;= pH &lt;= 5.4) in the presence of nonsynergistic anions occurs in at least five kinetic steps.	Iron	0-4	transferrin	Homo sapiens	48-59
22356162-0	2012	Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin.	Iron	138-142	transferrin	Homo sapiens	61-72
22356162-0	2012	Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin.	Iron	138-142	transferrin	Homo sapiens	160-171
22356162-1	2012	The recent crystal structure of two monoferric human serum transferrin (Fe(N)hTF) molecules bound to the soluble portion of the homodimeric transferrin receptor (sTFR) has provided new details about this binding interaction that dictates the delivery of iron to cells.	Iron	254-258	transferrin	Homo sapiens	59-70
22262835-1	2012	Nitrogen monoxide (NO) markedly affects intracellular iron metabolism, and recent studies have shown that molecules traditionally involved in drug resistance, namely GST and MRP1 (multidrug resistance-associated protein 1), are critical molecular players in this process.	Iron	54-58	ATP binding cassette subfamily C member 1	Homo sapiens	174-178
22262835-1	2012	Nitrogen monoxide (NO) markedly affects intracellular iron metabolism, and recent studies have shown that molecules traditionally involved in drug resistance, namely GST and MRP1 (multidrug resistance-associated protein 1), are critical molecular players in this process.	Iron	54-58	ATP binding cassette subfamily C member 1	Homo sapiens	180-221
22262835-10	2012	The generation of dinitrosyl-dithiol-iron complexes acts as a common currency for NO transport and storage by MRP1 and GST P1-1, respectively.	Iron	37-41	ATP binding cassette subfamily C member 1	Homo sapiens	110-114
20619503-1	2012	The 2 major types of neurodegeneration with brain iron accumulation (NBIA) are the pantothenate kinase type 2 (PANK2)-associated neurodegeneration (PKAN) and NBIA2 or infantile neuroaxonal dystrophy (INAD) due to mutations in the phospholipase A2, group VI (PLA2G6) gene.	Iron	50-54	pantothenate kinase 2	Homo sapiens	83-109
20619503-1	2012	The 2 major types of neurodegeneration with brain iron accumulation (NBIA) are the pantothenate kinase type 2 (PANK2)-associated neurodegeneration (PKAN) and NBIA2 or infantile neuroaxonal dystrophy (INAD) due to mutations in the phospholipase A2, group VI (PLA2G6) gene.	Iron	50-54	pantothenate kinase 2	Homo sapiens	111-116
20619503-1	2012	The 2 major types of neurodegeneration with brain iron accumulation (NBIA) are the pantothenate kinase type 2 (PANK2)-associated neurodegeneration (PKAN) and NBIA2 or infantile neuroaxonal dystrophy (INAD) due to mutations in the phospholipase A2, group VI (PLA2G6) gene.	Iron	50-54	phospholipase A2 group VI	Homo sapiens	230-256
20619503-1	2012	The 2 major types of neurodegeneration with brain iron accumulation (NBIA) are the pantothenate kinase type 2 (PANK2)-associated neurodegeneration (PKAN) and NBIA2 or infantile neuroaxonal dystrophy (INAD) due to mutations in the phospholipase A2, group VI (PLA2G6) gene.	Iron	50-54	phospholipase A2 group VI	Homo sapiens	258-264
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	65-69	LYR motif containing 4	Homo sapiens	37-42
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	130-134	LYR motif containing 4	Homo sapiens	37-42
22449975-0	2012	GSH threshold requirement for NO-mediated expression of the Arabidopsis AtFer1 ferritin gene in response to iron.	Iron	108-112	ferretin 1	Arabidopsis thaliana	72-78
22449975-1	2012	Iron treatment of Arabidopsis cultured cells promotes a rapid NO burst within chloroplasts, necessary for up-regulation of the AtFer1 ferritin gene expression.	Iron	0-4	ferretin 1	Arabidopsis thaliana	127-133
22449975-3	2012	A leaf GSH concentration threshold between 10 and 50 nmol GSHg(-1) FW is required for full induction of AtFer1 gene expression in response to iron.	Iron	142-146	ferretin 1	Arabidopsis thaliana	104-110
22150160-6	2012	In the present study, we show that a MATE (multidrug and toxic compound extrusion) transporter, designated BCD1 (BUSH-AND-CHLOROTIC-DWARF 1), contributes to iron homoeostasis during stress responses and senescence in Arabidopsis.	Iron	157-161	MATE efflux family protein	Arabidopsis thaliana	107-111
22150160-6	2012	In the present study, we show that a MATE (multidrug and toxic compound extrusion) transporter, designated BCD1 (BUSH-AND-CHLOROTIC-DWARF 1), contributes to iron homoeostasis during stress responses and senescence in Arabidopsis.	Iron	157-161	MATE efflux family protein	Arabidopsis thaliana	113-139
22150160-7	2012	The BCD1 gene is induced by excessive iron, but repressed by iron deficiency.	Iron	38-42	MATE efflux family protein	Arabidopsis thaliana	4-8
22150160-11	2012	Whereas the bcd1-1D mutant accumulated a lower amount of iron, the iron level was elevated in the knockout mutant bcd1-1.	Iron	57-61	MATE efflux family protein	Arabidopsis thaliana	12-16
22150160-11	2012	Whereas the bcd1-1D mutant accumulated a lower amount of iron, the iron level was elevated in the knockout mutant bcd1-1.	Iron	57-61	MATE efflux family protein	Arabidopsis thaliana	12-18
22150160-13	2012	We propose that the BCD1 transporter plays a role in sustaining iron homoeostasis by reallocating excess iron released from stress-induced cellular damage.	Iron	64-68	MATE efflux family protein	Arabidopsis thaliana	20-24
22150160-13	2012	We propose that the BCD1 transporter plays a role in sustaining iron homoeostasis by reallocating excess iron released from stress-induced cellular damage.	Iron	105-109	MATE efflux family protein	Arabidopsis thaliana	20-24
22307234-0	2012	Iron-catalysed tandem cross-dehydrogenative coupling (CDC) of terminal allylic C(sp3) to C(sp2) of styrene and benzoannulation in the synthesis of polysubstituted naphthalenes.	Iron	0-4	Sp2 transcription factor	Homo sapiens	89-94
22253436-2	2012	FBXL5 is a subunit of an E3 ubiquitin ligase complex that mediates the stability of iron regulatory protein 2, an important posttranscriptional regulator of several genes involved in iron metabolism.	Iron	84-88	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
22253436-3	2012	The stability of FBXL5 is regulated in an iron- and oxygen-responsive manner, contingent upon the presence of its N-terminal domain.	Iron	42-46	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
22301935-1	2012	BACKGROUND: Transmembrane protease serine 6 (TMPRSS6) regulates iron homeostasis by inhibiting the expression of hepcidin.	Iron	64-68	transmembrane serine protease 6	Homo sapiens	12-43
22262486-0	2012	Thrombocytosis and venous thromboembolism in cancer patients with chemotherapy induced anemia may be related to ESA induced iron restricted erythropoiesis and reversed by administration of IV iron.	Iron	124-128	paraoxonase 1	Homo sapiens	112-115
22262486-0	2012	Thrombocytosis and venous thromboembolism in cancer patients with chemotherapy induced anemia may be related to ESA induced iron restricted erythropoiesis and reversed by administration of IV iron.	Iron	192-196	paraoxonase 1	Homo sapiens	112-115
22262486-2	2012	Despite its benefits, ESA therapy increases the risk of venous thromboembolism (VTE) in cancer patients by 50% and can also cause iron restricted erythropoiesis in CIA patients, which may augment the tendency to develop VTE.	Iron	130-134	paraoxonase 1	Homo sapiens	22-25
22262486-3	2012	We postulated that thrombocytosis, a risk factor for VTE in cancer patients, in CIA patients on ESA therapy might be a result of ESA induced iron restricted erythropoiesis.	Iron	141-145	paraoxonase 1	Homo sapiens	96-99
22262486-3	2012	We postulated that thrombocytosis, a risk factor for VTE in cancer patients, in CIA patients on ESA therapy might be a result of ESA induced iron restricted erythropoiesis.	Iron	141-145	paraoxonase 1	Homo sapiens	129-132
22262486-7	2012	Our study suggests that ESA associated VTE in CIA patients may be, in part, related to the thrombocytosis of ESA induced iron restricted erythropoiesis and may be countered by IV iron.	Iron	121-125	paraoxonase 1	Homo sapiens	24-27
22262486-7	2012	Our study suggests that ESA associated VTE in CIA patients may be, in part, related to the thrombocytosis of ESA induced iron restricted erythropoiesis and may be countered by IV iron.	Iron	121-125	paraoxonase 1	Homo sapiens	109-112
22262486-7	2012	Our study suggests that ESA associated VTE in CIA patients may be, in part, related to the thrombocytosis of ESA induced iron restricted erythropoiesis and may be countered by IV iron.	Iron	179-183	paraoxonase 1	Homo sapiens	24-27
21699959-0	2012	Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.	Iron	12-16	transferrin	Homo sapiens	30-41
21810453-5	2012	MAJOR CONCLUSIONS: Insect transferrin can have one or two lobes, and can bind iron in one or both.	Iron	78-82	transferrin	Homo sapiens	26-37
21810453-6	2012	The iron binding ligands identified for the lobes of mammalian blood transferrin are generally conserved in the lobes of insect transferrins that have an iron binding site.	Iron	4-8	transferrin	Homo sapiens	69-80
21810453-6	2012	The iron binding ligands identified for the lobes of mammalian blood transferrin are generally conserved in the lobes of insect transferrins that have an iron binding site.	Iron	154-158	transferrin	Homo sapiens	69-80
21810453-7	2012	Available information supports that the form of dietary iron consumed influences the regulation of insect transferrin.	Iron	56-60	transferrin	Homo sapiens	106-117
21810453-11	2012	In addition to the roles of transferrin in iron delivery, this protein also functions to reduce oxidative stress and to enhance survival of infection.	Iron	43-47	transferrin	Homo sapiens	28-39
21810453-12	2012	GENERAL SIGNIFICANCE: Future studies in Tsf1 as well as the other insect transferrins that bind iron are warranted because of the roles of transferrin in preventing oxidative stress, enhancing survival to infections and delivering iron to eggs for development.	Iron	96-100	transferrin	Homo sapiens	73-84
21810453-12	2012	GENERAL SIGNIFICANCE: Future studies in Tsf1 as well as the other insect transferrins that bind iron are warranted because of the roles of transferrin in preventing oxidative stress, enhancing survival to infections and delivering iron to eggs for development.	Iron	231-235	transferrin	Homo sapiens	73-84
21892721-0	2012	Body iron stores as predictors of insulin resistance in apparently healthy urban Colombian men.	Iron	5-9	insulin	Homo sapiens	34-41
21892721-1	2012	The aim of this study was to evaluate body iron stores as predictors of insulin resistance.	Iron	43-47	insulin	Homo sapiens	72-79
21892721-8	2012	To our knowledge, this is the first evaluation of the relationship between body iron stores and insulin resistance in a Latin American population.	Iron	80-84	insulin	Homo sapiens	96-103
21933698-6	2012	GENERAL SIGNIFICANCE: An investigation of the molecular mechanisms of action of FbpA as a member of the transferrin super family enhances our understanding of bacterial mechanisms for acquisition of the essential nutrient iron, as well as the modes of action of human transferrin, and may provide approaches to the control of pathogenic diseases.	Iron	222-226	transferrin	Homo sapiens	104-115
21968002-1	2012	BACKGROUND: Transferrin (Tf) is an iron-binding protein that facilitates iron-uptake in cells.	Iron	35-39	transferrin	Homo sapiens	12-23
21968002-1	2012	BACKGROUND: Transferrin (Tf) is an iron-binding protein that facilitates iron-uptake in cells.	Iron	35-39	transferrin	Homo sapiens	25-27
21968002-1	2012	BACKGROUND: Transferrin (Tf) is an iron-binding protein that facilitates iron-uptake in cells.	Iron	73-77	transferrin	Homo sapiens	12-23
21968002-1	2012	BACKGROUND: Transferrin (Tf) is an iron-binding protein that facilitates iron-uptake in cells.	Iron	73-77	transferrin	Homo sapiens	25-27
21968002-2	2012	Iron-loaded Tf first binds to the Tf receptor (TfR) and enters the cell through clathrin-mediated endocytosis.	Iron	0-4	transferrin	Homo sapiens	12-14
21968002-3	2012	Inside the cell, Tf is trafficked to early endosomes, delivers iron, and then is subsequently directed to recycling endosomes to be taken back to the cell surface.	Iron	63-67	transferrin	Homo sapiens	17-19
22085723-4	2012	Plasma transferrin has been known for years as a central player in iron metabolism, assigned to circulate iron in a soluble, non-toxic form and deliver it to the erythron and other tissues.	Iron	67-71	transferrin	Homo sapiens	7-18
22085723-4	2012	Plasma transferrin has been known for years as a central player in iron metabolism, assigned to circulate iron in a soluble, non-toxic form and deliver it to the erythron and other tissues.	Iron	106-110	transferrin	Homo sapiens	7-18
22085723-5	2012	Recent data uncovered an additional role of transferrin as an upstream regulator of hepcidin, a liver-derived peptide hormone that controls systemic iron traffic.	Iron	149-153	transferrin	Homo sapiens	44-55
22085723-6	2012	SCOPE OF REVIEW: Here, we review basic features of iron metabolism, highlighting the function of transferrin in iron transport and cellular iron uptake.	Iron	51-55	transferrin	Homo sapiens	97-108
22085723-6	2012	SCOPE OF REVIEW: Here, we review basic features of iron metabolism, highlighting the function of transferrin in iron transport and cellular iron uptake.	Iron	112-116	transferrin	Homo sapiens	97-108
22085723-6	2012	SCOPE OF REVIEW: Here, we review basic features of iron metabolism, highlighting the function of transferrin in iron transport and cellular iron uptake.	Iron	112-116	transferrin	Homo sapiens	97-108
22085723-8	2012	Emphasis is given on the role of transferrin on iron-dependent hepcidin regulation.	Iron	48-52	transferrin	Homo sapiens	33-44
22085723-9	2012	MAJOR CONCLUSIONS: Transferrin exerts a crucial function in the maintenance of systemic iron homeostasis as component of a plasma iron sensing system that modulates hepcidin expression.	Iron	88-92	transferrin	Homo sapiens	19-30
22085723-9	2012	MAJOR CONCLUSIONS: Transferrin exerts a crucial function in the maintenance of systemic iron homeostasis as component of a plasma iron sensing system that modulates hepcidin expression.	Iron	130-134	transferrin	Homo sapiens	19-30
22085723-10	2012	GENERAL SIGNIFICANCE: Proper expression of transferrin and hepcidin are essential for health, and disruption of their regulatory circuits is associated with iron-related disorders.	Iron	157-161	transferrin	Homo sapiens	43-54
22155077-0	2012	Iron mobilization from transferrin by therapeutic iron chelating agents.	Iron	50-54	transferrin	Homo sapiens	23-34
22155077-2	2012	The possession of high affinity iron(III)-binding sites and the existence of a specific membrane-bound receptor, have led to the present understanding of serum transferrin acting as the major iron transporter between cells in vertebrate systems.	Iron	32-36	transferrin	Homo sapiens	160-171
22155077-3	2012	Iron chelators can interact with transferrin, either by directly donating iron or by removing iron from the protein; both interactions have relevance for haematology.	Iron	0-4	transferrin	Homo sapiens	33-44
22155077-3	2012	Iron chelators can interact with transferrin, either by directly donating iron or by removing iron from the protein; both interactions have relevance for haematology.	Iron	74-78	transferrin	Homo sapiens	33-44
22155077-3	2012	Iron chelators can interact with transferrin, either by directly donating iron or by removing iron from the protein; both interactions have relevance for haematology.	Iron	94-98	transferrin	Homo sapiens	33-44
22155077-5	2012	MAJOR CONCLUSIONS: Negatively charged ligands with pFe values >20 remove iron from transferrin, preferably from the N-lobe iron-binding site.	Iron	73-77	transferrin	Homo sapiens	83-94
22354243-7	2012	In 35 patients with iron studies, perioperative transfusions were directly related to postoperative transferrin saturation (correlation coefficient 0.6; P = 0.0002), and high (more than 80%) transferrin saturation was associated with AKI (5/5 vs. 8/30; P = 0.005), implicating transfusion-related iron overload as a cause of AKI.	Iron	297-301	transferrin	Homo sapiens	191-202
21726602-1	2012	BACKGROUND: Transferrin (Tf) is a paradigmatic metalloprotein, which has been extensively studied in the past and still is a focal point of numerous investigation efforts owing to its unique role in iron homeostasis and enormous promise as a component of a wide range of therapies.	Iron	199-203	transferrin	Homo sapiens	12-23
21726602-1	2012	BACKGROUND: Transferrin (Tf) is a paradigmatic metalloprotein, which has been extensively studied in the past and still is a focal point of numerous investigation efforts owing to its unique role in iron homeostasis and enormous promise as a component of a wide range of therapies.	Iron	199-203	transferrin	Homo sapiens	25-27
21726602-4	2012	GENERAL SIGNIFICANCE: The experimental ESI MS-based techniques developed for Tf studies are not only useful for understanding of fundamental aspects of the iron-binding properties of this protein and optimizing Tf-based therapeutic products, but can also be applied to study a range of other metalloproteins.	Iron	156-160	transferrin	Homo sapiens	77-79
21782896-1	2012	BACKGROUND: The iron transport protein of the blood plasma, transferrin, is maintained only with about 30% of its capacity to bind Fe(3+) ions; this leaves the protein the potential ability to transport other metal ions from the bloodstream to the tissues.	Iron	16-20	transferrin	Homo sapiens	60-71
21843602-4	2012	SCOPE OF REVIEW: Iron-loaded transferrin (Tf) binds with high affinity to the specific transferrin receptor (TfR) on the cell surface.	Iron	17-21	transferrin	Homo sapiens	29-40
21843602-7	2012	GENERAL SIGNIFICANCE: The interaction of the iron-loaded transferrin with the transferrin receptor is a key cellular process that occurs during the normal course of iron metabolism.	Iron	45-49	transferrin	Homo sapiens	57-68
21843602-7	2012	GENERAL SIGNIFICANCE: The interaction of the iron-loaded transferrin with the transferrin receptor is a key cellular process that occurs during the normal course of iron metabolism.	Iron	165-169	transferrin	Homo sapiens	57-68
21843602-10	2012	Iron-loaded transferrin (monoferric or diferric) is shown to bind avidly (K~10(7)-10(8)M(-1)) to the receptor at neutral pH with a stoichiometry of one Tf molecule per TfR monomer.	Iron	0-4	transferrin	Homo sapiens	12-23
21846492-13	2012	The KISAB sites have not been well-characterized, but kinetic studies on iron release from mutant transferrins indicate that there are likely to be multiple KISAB sites for each lobe of transferrin.	Iron	73-77	transferrin	Homo sapiens	98-109
21851850-3	2012	The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin.	Iron	53-57	transferrin	Homo sapiens	4-15
21854833-3	2012	In mammals are presents two different soluble glycoproteins with different functions: i) serum transferrin that is present in plasma and committed to iron transport and iron delivery to cells and ii) lactoferrin that is present in extracellular fluids and in specific granules of polymorphonuclear lymphocytes and committed to the so-called natural immunity.	Iron	150-154	transferrin	Homo sapiens	95-106
21854833-3	2012	In mammals are presents two different soluble glycoproteins with different functions: i) serum transferrin that is present in plasma and committed to iron transport and iron delivery to cells and ii) lactoferrin that is present in extracellular fluids and in specific granules of polymorphonuclear lymphocytes and committed to the so-called natural immunity.	Iron	169-173	transferrin	Homo sapiens	95-106
21855608-0	2012	Non-transferrin bound iron: a key role in iron overload and iron toxicity.	Iron	22-26	transferrin	Homo sapiens	4-15
21855608-0	2012	Non-transferrin bound iron: a key role in iron overload and iron toxicity.	Iron	42-46	transferrin	Homo sapiens	4-15
21855608-0	2012	Non-transferrin bound iron: a key role in iron overload and iron toxicity.	Iron	42-46	transferrin	Homo sapiens	4-15
21855608-1	2012	BACKGROUND: Besides transferrin iron, which represents the normal form of circulating iron, non-transferrin bound iron (NTBI) has been identified in the plasma of patients with various pathological conditions in which transferrin saturation is significantly elevated.	Iron	32-36	transferrin	Homo sapiens	20-31
21855609-1	2012	BACKGROUND: Transferrins are a group of iron-binding proteins including serum transferrin, lactoferrin and ovotransferrin.	Iron	40-44	transferrin	Homo sapiens	78-89
21855609-7	2012	The iron-release mechanism of transferrin N-lobe is also revealed by X-ray crystallography; two basic residues in two domains form an unusual hydrogen bond in neutral pH, and the bond should be broken and facilitate iron release at a low pH of the endosome.	Iron	4-8	transferrin	Homo sapiens	30-41
21855609-7	2012	The iron-release mechanism of transferrin N-lobe is also revealed by X-ray crystallography; two basic residues in two domains form an unusual hydrogen bond in neutral pH, and the bond should be broken and facilitate iron release at a low pH of the endosome.	Iron	216-220	transferrin	Homo sapiens	30-41
21872645-1	2012	BACKGROUND: For a metal to follow the iron acquisition pathway, four conditions are required: 1-complex formation with transferrin; 2-interaction with receptor 1; 3-metal release in the endosome; and 4-metal transport to cytosol.	Iron	38-42	transferrin	Homo sapiens	119-130
22138408-2	2012	Transferrin is a major iron delivery protein to the brain, but the amount transcytosed across the brain microvasculature is minimal.	Iron	23-27	transferrin	Homo sapiens	0-11
22138408-3	2012	Transferrin is the major source of iron delivery to neurons.	Iron	35-39	transferrin	Homo sapiens	0-11
22138408-5	2012	Finally, transferrin may play an important role in neurodegenerative diseases through its ability to mobilize iron.	Iron	110-114	transferrin	Homo sapiens	9-20
22138408-6	2012	SCOPE OF REVIEW: The role of transferrin in maintaining brain iron homeostasis and the mechanism by which it enters the brain and delivers iron will be discussed.	Iron	62-66	transferrin	Homo sapiens	29-40
22138408-6	2012	SCOPE OF REVIEW: The role of transferrin in maintaining brain iron homeostasis and the mechanism by which it enters the brain and delivers iron will be discussed.	Iron	139-143	transferrin	Homo sapiens	29-40
22138408-8	2012	MAJOR CONCLUSIONS: Transferrin is the major iron delivery protein for neurons and the microvasculature, but has a limited role for glial cells.	Iron	44-48	transferrin	Homo sapiens	19-30
22138408-11	2012	GENERAL SIGNIFICANCE: Neuron survival requires iron, which is predominantly delivered by transferrin.	Iron	47-51	transferrin	Homo sapiens	89-100
22138408-12	2012	The concentration of transferrin in the cerebrospinal fluid is reflective of brain iron availability and can function as a biomarker in disease.	Iron	83-87	transferrin	Homo sapiens	21-32
22138408-13	2012	Accumulation of iron in the brain contributes to neurodegenerative processes, thus an understanding of the role that transferrin plays in regulating brain iron homeostasis is essential.	Iron	16-20	transferrin	Homo sapiens	117-128
22138408-13	2012	Accumulation of iron in the brain contributes to neurodegenerative processes, thus an understanding of the role that transferrin plays in regulating brain iron homeostasis is essential.	Iron	155-159	transferrin	Homo sapiens	117-128
22155077-0	2012	Iron mobilization from transferrin by therapeutic iron chelating agents.	Iron	0-4	transferrin	Homo sapiens	23-34
22155077-5	2012	MAJOR CONCLUSIONS: Negatively charged ligands with pFe values >20 remove iron from transferrin, preferably from the N-lobe iron-binding site.	Iron	123-127	transferrin	Homo sapiens	83-94
22155077-7	2012	3-Hydroxypyridin-4-ones, lacking a negative charge are able to remove iron from transferrin with a strong preference for the C- lobe iron-binding site.	Iron	70-74	transferrin	Homo sapiens	80-91
22155077-7	2012	3-Hydroxypyridin-4-ones, lacking a negative charge are able to remove iron from transferrin with a strong preference for the C- lobe iron-binding site.	Iron	133-137	transferrin	Homo sapiens	80-91
22155077-8	2012	The donation of iron to apo transferrin by hydroxypyridinone iron(III) complexes has relevance to the treatment of clinical anaemias, because the hydroxypyridinones can also mobilize iron from the reticuloendothelial system and so facilitate the redistribution of iron from macrophages to reticulocytes.	Iron	16-20	transferrin	Homo sapiens	28-39
22155077-8	2012	The donation of iron to apo transferrin by hydroxypyridinone iron(III) complexes has relevance to the treatment of clinical anaemias, because the hydroxypyridinones can also mobilize iron from the reticuloendothelial system and so facilitate the redistribution of iron from macrophages to reticulocytes.	Iron	61-65	transferrin	Homo sapiens	28-39
22155077-8	2012	The donation of iron to apo transferrin by hydroxypyridinone iron(III) complexes has relevance to the treatment of clinical anaemias, because the hydroxypyridinones can also mobilize iron from the reticuloendothelial system and so facilitate the redistribution of iron from macrophages to reticulocytes.	Iron	61-65	transferrin	Homo sapiens	28-39
22301935-1	2012	BACKGROUND: Transmembrane protease serine 6 (TMPRSS6) regulates iron homeostasis by inhibiting the expression of hepcidin.	Iron	64-68	transmembrane serine protease 6	Homo sapiens	45-52
22301935-2	2012	Multiple common variants in TMPRSS6 were significantly associated with serum iron in recent genome-wide association studies, but their effects in the Chinese remain to be elucidated.	Iron	77-81	transmembrane serine protease 6	Homo sapiens	28-35
22301935-4	2012	DESIGN: The SNPs rs855791(V736A) and rs4820268(D521D) in the TMPRSS6 gene were genotyped and tested for their associations with plasma iron and type 2 diabetes risk in 1574 unrelated Chinese Hans from Beijing.	Iron	135-139	transmembrane serine protease 6	Homo sapiens	61-68
22301935-5	2012	RESULTS: The 2 TMPRSS6 SNPs rs855791(V736A) and rs4820268(D521D) were both significantly associated with plasma ferritin (P &lt;= 0.0058), hemoglobin (P &lt;= 0.0013), iron overload risk (P &lt;= 0.0068), and type 2 diabetes risk (P &lt;= 0.0314).	Iron	168-172	transmembrane serine protease 6	Homo sapiens	15-22
22301935-8	2012	CONCLUSIONS: These findings suggest that TMPRSS6 variants were significantly associated with plasma ferritin, hemoglobin, risk of iron overload, and type 2 diabetes in Chinese Hans.	Iron	130-134	transmembrane serine protease 6	Homo sapiens	41-48
22325059-8	2012	We have found that protein isoaspartyl methyltransferase (PIMT) and pirin (iron-binding nuclear protein, PIR) with lower expression in RA, and thioredoxin 1(Trx-1) only expressed in RA may be associated with functions of FLS.	Iron	75-79	pirin	Homo sapiens	68-73
22170771-8	2012	The results suggest that diabetes, with or without excess iron, can cause perturbations in iron status, hepcidin and Trf-1 expression.	Iron	58-62	hepcidin antimicrobial peptide	Rattus norvegicus	104-112
22187487-10	2012	The molecular docking study showed that the N-ethyl moiety of CP-945,598 can access to the heme iron-oxo of CYP3A4 in an energetically favored orientation.	Iron	96-100	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
22325059-8	2012	We have found that protein isoaspartyl methyltransferase (PIMT) and pirin (iron-binding nuclear protein, PIR) with lower expression in RA, and thioredoxin 1(Trx-1) only expressed in RA may be associated with functions of FLS.	Iron	75-79	pirin	Homo sapiens	105-108
22456916-10	2012	Anemia with functional iron deficiency (transferrin saturation &lt; 20%) should be treated with intravenous iron, as oral iron is ineffective being not absorbed.	Iron	23-27	transferrin	Homo sapiens	40-51
22125086-1	2012	Hereditary myopathy with lactic acidosis (HML) is caused by an intron mutation in the iron-sulfur cluster assembly gene ISCU, which leads to the activation of cryptic splice sites and the retention of part of intron 4.	Iron	86-90	iron-sulfur cluster assembly enzyme	Homo sapiens	120-124
22038922-6	2012	Iron and BCL2-interacting mediator of cell death (BIM) protein were involved in LCN2-induced cell death sensitization, based on the studies using iron donor, chelator, siderophore, and short hairpin RNA (shRNA)-mediated knockdown of bim expression.	Iron	146-150	BCL2 apoptosis regulator	Homo sapiens	9-13
22456916-10	2012	Anemia with functional iron deficiency (transferrin saturation &lt; 20%) should be treated with intravenous iron, as oral iron is ineffective being not absorbed.	Iron	108-112	transferrin	Homo sapiens	40-51
22033148-2	2012	Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor.	Iron	0-4	haptoglobin	Homo sapiens	97-108
22033148-2	2012	Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor.	Iron	0-4	solute carrier family 11 member 1	Homo sapiens	121-127
22033148-2	2012	Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor.	Iron	0-4	transferrin	Homo sapiens	149-160
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
22221393-1	2012	Pantothenate kinase-associated neurodegeneration (PKAN) is a rare, inborn error of metabolism characterized by iron accumulation in the basal ganglia and by the presence of dystonia, dysarthria, and retinal degeneration.	Iron	111-115	pantothenate kinase 2	Homo sapiens	0-48
22221393-1	2012	Pantothenate kinase-associated neurodegeneration (PKAN) is a rare, inborn error of metabolism characterized by iron accumulation in the basal ganglia and by the presence of dystonia, dysarthria, and retinal degeneration.	Iron	111-115	pantothenate kinase 2	Homo sapiens	50-54
22257001-5	2012	In contrast, Cyc2p is able to catalyse the NAD(P)H-dependent reduction of hemin, an indication that the protein"s role may be to control the redox state of the iron in the haem attachment reaction to apocytochromes c. Using two-hybrid analysis, we show that Cyc2p interacts with CCHL and also with apocytochromes c and c(1) .	Iron	160-164	oxidoreductase	Saccharomyces cerevisiae S288C	13-18
22257001-5	2012	In contrast, Cyc2p is able to catalyse the NAD(P)H-dependent reduction of hemin, an indication that the protein"s role may be to control the redox state of the iron in the haem attachment reaction to apocytochromes c. Using two-hybrid analysis, we show that Cyc2p interacts with CCHL and also with apocytochromes c and c(1) .	Iron	160-164	oxidoreductase	Saccharomyces cerevisiae S288C	258-263
22257001-6	2012	We postulate that Cyc2p, possibly in a complex with CCHL, reduces the haem iron prior to haem attachment to the apoforms of cytochrome c and c(1) .	Iron	75-79	oxidoreductase	Saccharomyces cerevisiae S288C	18-23
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	transferrin	Homo sapiens	202-213
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	transferrin	Homo sapiens	202-213
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	transferrin	Homo sapiens	202-213
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	220-224	transferrin	Homo sapiens	202-213
22281055-5	2012	We also demonstrated that Fpn1 expression was significantly affected by HIF-1alpha, implying that the gene encoding this iron efflux protein is hypoxia-inducible.	Iron	121-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-82
22155317-2	2012	The disease is recessively inherited and caused by a deep intronic, single base transition in the iron-sulfur cluster scaffold, ISCU gene that causes retention of a pseudoexon and introduction of a premature termination codon.	Iron	98-102	iron-sulfur cluster assembly enzyme	Homo sapiens	128-132
22364629-13	2012	CONCLUSION: Preparation by erythropoietin before severe hypospadias surgery seemed to have several advantages: a more elevated hematocrit after surgery than with an iron preparation alone, and a lower rate of postoperative complications, including fistulas and necrosis of the preputial flap.	Iron	165-169	erythropoietin	Homo sapiens	27-41
22155317-3	2012	IscU protein deficiency causes secondary defects in several iron-sulfur dependant proteins, including enzymes involved in aerobic energy metabolism.	Iron	60-64	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
22265928-2	2012	We sought to identify relationships of TMPRSS6 K253E, A736V, and Y739Y to iron, erythrocyte, and pica phenotypes in women with iron deficiency or depletion.	Iron	74-78	transmembrane serine protease 6	Homo sapiens	39-46
23211049-10	2012	Among the strongest arguments against a common pathophysiology is the role of iron in RLS and PD.	Iron	78-82	RLS1	Homo sapiens	86-89
22343719-0	2012	The structural basis of transferrin sequestration by transferrin-binding protein B. Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB.	Iron	184-188	transferrin	Homo sapiens	24-35
22343719-0	2012	The structural basis of transferrin sequestration by transferrin-binding protein B. Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB.	Iron	184-188	transferrin	Homo sapiens	53-64
22343719-0	2012	The structural basis of transferrin sequestration by transferrin-binding protein B. Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB.	Iron	184-188	transferrin	Homo sapiens	53-64
22343719-0	2012	The structural basis of transferrin sequestration by transferrin-binding protein B. Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB.	Iron	184-188	transferrin	Homo sapiens	53-64
22343719-2	2012	The structure reveals how TbpB sequesters and initiates iron release from human transferrin.	Iron	56-60	transferrin	Homo sapiens	80-91
22169218-1	2012	Mutations in TMPRSS6 gene cause iron-refractory iron deficiency anemia, a rare autosomal recessive disorder characterized by hypochromic microcytic anemia not responsive to oral iron therapy and partially responsive to parenteral iron administration.	Iron	32-36	transmembrane serine protease 6	Homo sapiens	13-20
22169218-1	2012	Mutations in TMPRSS6 gene cause iron-refractory iron deficiency anemia, a rare autosomal recessive disorder characterized by hypochromic microcytic anemia not responsive to oral iron therapy and partially responsive to parenteral iron administration.	Iron	48-52	transmembrane serine protease 6	Homo sapiens	13-20
22169218-2	2012	Here we report a female infant homozygous for a loss of function mutation in TMPRSS6 gene, who responded to oral iron therapy when supplemented with ascorbic acid.	Iron	113-117	transmembrane serine protease 6	Homo sapiens	77-84
22172990-1	2012	The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated gastrins in vitro and in vivo.	Iron	74-78	gastrin	Mus musculus	20-27
22155297-7	2012	Second, amyloid-beta peptide generates ROS in the presence of metal ions such as Fe(2+) and Cu(2+).	Iron	81-83	amyloid beta precursor protein	Homo sapiens	8-20
22327295-2	2012	Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane.	Iron	18-22	transferrin	Homo sapiens	75-86
22327295-4	2012	Two key questions driving Neisseria research are how human transferrin is specifically targeted, and how the bacteria liberate iron from transferrin at neutral pH.	Iron	127-131	transferrin	Homo sapiens	137-148
22327295-7	2012	Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process.	Iron	111-115	transferrin	Homo sapiens	75-86
22327295-7	2012	Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process.	Iron	111-115	transferrin	Homo sapiens	129-140
22089858-2	2012	Considerably less is known about the effect of increased plasma levels of redox-reactive non-transferrin bound iron (NTBI) and its impact on pulmonary endothelium.	Iron	111-115	transferrin	Rattus norvegicus	93-104
22400942-0	2012	Structure of iron to 1 Gbar and 40, 000 K. First-principles calculations show that compression-induced electronic transitions produce a rich phase diagram featuring reentrant stability of the fcc phase with an extremum on the fcc to hcp boundary at 23 Mbar and 19 000 K, conditions similar to those expected at the center of super-Earth exoplanets.	Iron	13-17	adaptor related protein complex 1 associated regulatory protein	Homo sapiens	23-27
22120775-6	2012	Insulin resistance was most strongly associated with markers of inflammation and somatic iron overload, while disposition index (DI) (a measure of beta cell function) was most strongly correlated with pancreas R2*.	Iron	89-93	insulin	Homo sapiens	0-7
21826460-2	2012	ZIP proteins have been shown to mediate the cellular uptake of the essential trace elements zinc, iron, and manganese.	Iron	98-102	sequestosome 1	Rattus norvegicus	0-3
21826460-3	2012	The aim of the present study was to determine the effect of dietary iron deficiency and overload on the expression of all 14 ZIP transporters in the liver, the main site of iron storage.	Iron	68-72	sequestosome 1	Rattus norvegicus	125-128
21826460-10	2012	Studies in H4IIE hepatoma cells further documented that iron loading affects the expression of these ZIP transporters.	Iron	56-60	sequestosome 1	Rattus norvegicus	101-104
22089858-8	2012	The resulting iron-induced cell alterations were characterized by cell polarization and formation of membrane cuplike and microvilli-like projections abundant with ICAM-1, caveolin-1, and F-actin.	Iron	14-18	caveolin 1	Rattus norvegicus	172-182
21413014-0	2012	Hemin, an iron-binding porphyrin, inhibits HIF-1alpha induction through its binding with heat shock protein 90.	Iron	10-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
22309085-5	2012	Significantly elevated serum iron and transferrin saturation levels were observed in the ISS groups suggesting a higher release of iron resulting in higher amounts of non-transferrin bound (free) iron compared to IS(ORIG).	Iron	131-135	transferrin	Rattus norvegicus	38-49
22309085-5	2012	Significantly elevated serum iron and transferrin saturation levels were observed in the ISS groups suggesting a higher release of iron resulting in higher amounts of non-transferrin bound (free) iron compared to IS(ORIG).	Iron	131-135	transferrin	Rattus norvegicus	171-182
22309085-5	2012	Significantly elevated serum iron and transferrin saturation levels were observed in the ISS groups suggesting a higher release of iron resulting in higher amounts of non-transferrin bound (free) iron compared to IS(ORIG).	Iron	131-135	transferrin	Rattus norvegicus	38-49
22309085-5	2012	Significantly elevated serum iron and transferrin saturation levels were observed in the ISS groups suggesting a higher release of iron resulting in higher amounts of non-transferrin bound (free) iron compared to IS(ORIG).	Iron	131-135	transferrin	Rattus norvegicus	171-182
22261528-7	2012	iron we identified 26 patients who received EPO in concordance to our inclusion criteria.	Iron	0-4	erythropoietin	Homo sapiens	44-47
22261528-13	2012	iron monotherapy, administration of EPO significantly improved peripheral blood parameters with safety.	Iron	0-4	erythropoietin	Homo sapiens	36-39
22093255-1	2012	BACKGROUND: We previously reported that iron chelators inhibit TNFalpha-mediated induction of VCAM-1 in human dermal microvascular endothelial cells.	Iron	40-44	tumor necrosis factor	Homo sapiens	63-71
22093255-5	2012	RESULTS: Hypoxia and the non-iron binding hypoxia mimetic dimethyl oxallyl glycine (DMOG) inhibited TNFalpha-mediated induction of VCAM-1.	Iron	29-33	tumor necrosis factor	Homo sapiens	100-108
22093255-5	2012	RESULTS: Hypoxia and the non-iron binding hypoxia mimetic dimethyl oxallyl glycine (DMOG) inhibited TNFalpha-mediated induction of VCAM-1.	Iron	29-33	vascular cell adhesion molecule 1	Homo sapiens	131-137
22197672-4	2012	First is accessibility of each substrate atom to the oxygenated Fe atom of heme in a CYP protein, and the other is the oxidative reactivity of each substrate atom.	Iron	64-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88
22093255-8	2012	CONCLUSION: Iron chelators, non-metal binding hypoxia mimetics, and hypoxia all inhibit TNFalpha-mediated VCAM-1 expression.	Iron	12-16	tumor necrosis factor	Homo sapiens	88-96
22093255-8	2012	CONCLUSION: Iron chelators, non-metal binding hypoxia mimetics, and hypoxia all inhibit TNFalpha-mediated VCAM-1 expression.	Iron	12-16	vascular cell adhesion molecule 1	Homo sapiens	106-112
22190022-9	2012	Repletion with 20 mg FeSO4   kg diet-1 significantly increased cecal butyrate concentrations and partially restored bacterial populations compared to Fe-deficient rats at endpoint.	Iron	21-23	MAM and LDL receptor class A domain containing 1	Rattus norvegicus	32-38
22170477-3	2012	Control experiments showed that ligand 1 or Fe(II) alone showed no inhibition, whereas 2 was moderately active (IC(50) = 96 muM), suggesting that iron, when bound to these ligands, plays a key role in proteasome inhibition.	Iron	146-150	latexin	Homo sapiens	124-127
22374396-0	2012	Transcriptome sequencing identifies SPL7-regulated copper acquisition genes FRO4/FRO5 and the copper dependence of iron homeostasis in Arabidopsis.	Iron	115-119	squamosa promoter binding protein-like 7	Arabidopsis thaliana	36-40
22374396-5	2012	Plant iron (Fe) deficiency markers were activated in Cu-deficient media, in which reduced growth of the spl7 mutant was partially rescued by Fe supplementation.	Iron	6-10	squamosa promoter binding protein-like 7	Arabidopsis thaliana	104-108
22374396-5	2012	Plant iron (Fe) deficiency markers were activated in Cu-deficient media, in which reduced growth of the spl7 mutant was partially rescued by Fe supplementation.	Iron	12-14	squamosa promoter binding protein-like 7	Arabidopsis thaliana	104-108
22374396-5	2012	Plant iron (Fe) deficiency markers were activated in Cu-deficient media, in which reduced growth of the spl7 mutant was partially rescued by Fe supplementation.	Iron	141-143	squamosa promoter binding protein-like 7	Arabidopsis thaliana	104-108
22374397-9	2012	Therefore, accurate levels of ZIF1 expression are critical for both Zn and Fe homeostasis.	Iron	75-77	zinc induced facilitator 1	Arabidopsis thaliana	30-34
22198983-6	2012	MRI assessed lesion volume, atrophy, and the presence of iron-labeled CD34(+) cells reinjected on day 6.	Iron	57-61	CD34 molecule	Homo sapiens	70-74
22198983-14	2012	It is feasible to label and readminister iron-labeled CD34(+) cells in patients with ischemic stroke.	Iron	41-45	CD34 molecule	Homo sapiens	54-58
22258974-19	2012	AUTHORS" CONCLUSIONS: The included studies provide strong evidence for increased ferritin and transferrin saturation levels, together with a small increase in haemoglobin, in patients with CKD who were treated with IV iron compared with oral iron.	Iron	218-222	transferrin	Homo sapiens	94-105
21827279-1	2012	AIMS: Heme oxygenase-1 (HMOX1) is a cytoprotective enzyme degrading heme to biliverdin, iron ions, and carbon monoxide, whose expression is induced in response to oxidative stress.	Iron	88-92	heme oxygenase 1	Mus musculus	6-22
21827279-1	2012	AIMS: Heme oxygenase-1 (HMOX1) is a cytoprotective enzyme degrading heme to biliverdin, iron ions, and carbon monoxide, whose expression is induced in response to oxidative stress.	Iron	88-92	heme oxygenase 1	Mus musculus	24-29
22093255-1	2012	BACKGROUND: We previously reported that iron chelators inhibit TNFalpha-mediated induction of VCAM-1 in human dermal microvascular endothelial cells.	Iron	40-44	vascular cell adhesion molecule 1	Homo sapiens	94-100
22093255-2	2012	We hypothesized that iron chelators mediate inhibition of VCAM-1 via inhibition of iron-dependent enzymes such as those involved with oxygen sensing and that similar inhibition may be observed with agents which simulate hypoxia.	Iron	21-25	vascular cell adhesion molecule 1	Homo sapiens	58-64
22093255-2	2012	We hypothesized that iron chelators mediate inhibition of VCAM-1 via inhibition of iron-dependent enzymes such as those involved with oxygen sensing and that similar inhibition may be observed with agents which simulate hypoxia.	Iron	83-87	vascular cell adhesion molecule 1	Homo sapiens	58-64
22170477-2	2012	Results demonstrated that the iron complexes of both ligands are potent inhibitors of the 20S proteasome (IC(50) = 9.2 muM for [Fe(II)(OH(2))(N4Py)](2+) (3) and 4.0 muM for [Fe(II)(OH(2))(Bn-TPEN)](2+) (4)).	Iron	30-34	latexin	Homo sapiens	119-122
22170477-2	2012	Results demonstrated that the iron complexes of both ligands are potent inhibitors of the 20S proteasome (IC(50) = 9.2 muM for [Fe(II)(OH(2))(N4Py)](2+) (3) and 4.0 muM for [Fe(II)(OH(2))(Bn-TPEN)](2+) (4)).	Iron	30-34	latexin	Homo sapiens	165-168
22169147-1	2012	Palladized iron coated reactive geomembrane (Pd/Fe RGM) was developed to mitigate the mass transfer of chlorinated volatile organic compounds through HDPE geomembrane.	Iron	11-15	repulsive guidance molecule BMP co-receptor a	Homo sapiens	51-54
22169147-3	2012	This study focused on the effects of Pd/Fe coating on the mass transfer parameters and the reaction rate constant of RGM.	Iron	40-42	repulsive guidance molecule BMP co-receptor a	Homo sapiens	117-120
22169147-8	2012	The reactivity of Pd/Fe RGM decreased severely at 10mM sulfide concentration and with long-term aging of RGM in the atmosphere for three years.	Iron	21-23	repulsive guidance molecule BMP co-receptor a	Homo sapiens	24-27
22169147-8	2012	The reactivity of Pd/Fe RGM decreased severely at 10mM sulfide concentration and with long-term aging of RGM in the atmosphere for three years.	Iron	21-23	repulsive guidance molecule BMP co-receptor a	Homo sapiens	105-108
22191507-0	2012	Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release.	Iron	89-93	transferrin	Homo sapiens	30-41
22191507-1	2012	Efficient delivery of iron is critically dependent on the binding of diferric human serum transferrin (hTF) to its specific receptor (TFR) on the surface of actively dividing cells.	Iron	22-26	transferrin	Homo sapiens	90-101
22197672-10	2012	The experimentally known epoxidized sites of CBZ by CYP3A4 were successfully predicted as the most accessible sites to the heme iron that was judged from a numerical analysis of calculated DeltaG(binding) and the frequency of appearance.	Iron	128-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-58
22259433-1	2012	The title compound, C(9)H(12)ClN(4) (+) Cl(-), is a natural metabolic product of imidacloprid [systematic name: (E)-1-(6-chloro-3-pyridyl-meth-yl)-N-nitro-imidazolidin-2-yl-idene-amine] and was obtained by the reduction of the latter using Fe in HCl.	Iron	240-242	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	29-35
22087535-1	2012	Compounds that coordinate to the heme-iron of cytochrome P450 (CYP) enzymes are assumed to increase metabolic stability.	Iron	38-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-61
22087535-1	2012	Compounds that coordinate to the heme-iron of cytochrome P450 (CYP) enzymes are assumed to increase metabolic stability.	Iron	38-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-66
21946558-1	2012	A new regulatory pathway involved in plant response to oxidative stress was revealed using the iron-induced Arabidopsis ferritin AtFER1 as a model.	Iron	95-99	ferretin 1	Arabidopsis thaliana	129-135
22212390-5	2012	IV iron preparations raise plasma non-transferrin-bound iron which can promote oxidative stress, endothelial damage and dysfunction.	Iron	3-7	transferrin	Rattus norvegicus	38-49
22125177-0	2012	Non-transferrin bound iron in Thalassemia: differential detection of redox active forms in children and older patients.	Iron	22-26	transferrin	Homo sapiens	4-15
22212390-5	2012	IV iron preparations raise plasma non-transferrin-bound iron which can promote oxidative stress, endothelial damage and dysfunction.	Iron	56-60	transferrin	Rattus norvegicus	38-49
22125177-1	2012	Non-transferrin bound iron (NTBI) is commonly detected in patients with systemic iron overload whose serum iron-binding capacity has been surpassed.	Iron	22-26	transferrin	Homo sapiens	4-15
22125177-1	2012	Non-transferrin bound iron (NTBI) is commonly detected in patients with systemic iron overload whose serum iron-binding capacity has been surpassed.	Iron	81-85	transferrin	Homo sapiens	4-15
22797673-6	2012	CONCLUSION: Iron overload, which produces elevated levels of ferritin, may augment insulin resistance in female but not in male type 2 diabetes.	Iron	12-16	insulin	Homo sapiens	83-90
22125177-1	2012	Non-transferrin bound iron (NTBI) is commonly detected in patients with systemic iron overload whose serum iron-binding capacity has been surpassed.	Iron	81-85	transferrin	Homo sapiens	4-15
22138653-1	2012	A growing body of Alzheimer"s disease (AD) research is concerned with understanding the interaction between amyloid-beta (Abeta) peptides and metal ions (e.g., Cu, Zn, and Fe) and determining the biological relevance of the metal-Abeta complexes to essential metal homeostasis and neuronal cell loss.	Iron	172-174	amyloid beta precursor protein	Homo sapiens	108-120
22398912-0	2012	Impact of oral iron challenges on circulating non-transferrin-bound iron in healthy Guatemalan males.	Iron	15-19	transferrin	Homo sapiens	50-61
22398912-2	2012	A potential aggravating role of non-transferrin-bound iron (NTBI) has been proposed.	Iron	54-58	transferrin	Homo sapiens	36-47
21399668-8	2012	The prognostic impact of iron parameters was independent of other factors such as stage, conditioning regimen and CRP level, and operated similarly across diseases.	Iron	25-29	C-reactive protein	Homo sapiens	114-117
22400117-2	2012	In the original studies which showed the reduction of iron in transferrin by the plasma membranes NADH oxidase, the possible role of the reduction on iron uptake was emphasized.	Iron	54-58	transferrin	Homo sapiens	62-73
22400117-2	2012	In the original studies which showed the reduction of iron in transferrin by the plasma membranes NADH oxidase, the possible role of the reduction on iron uptake was emphasized.	Iron	150-154	transferrin	Homo sapiens	62-73
22400117-3	2012	The rapid reoxidation of transferrin iron under aerobic conditions precludes a role for surface reduction at neutral pH for release of iron for uptake at the plasma membrane.	Iron	37-41	transferrin	Homo sapiens	25-36
23207768-5	2012	Despite metal ion-dependent restoration of the inhibited HIF-1alpha hydroxylase activity, the cellular HIF-1alpha-inducing effects of the CQ analogues are reversed to varying degrees by Zn(2+) and Fe(2+).	Iron	197-199	hypoxia inducible factor 1 alpha subunit	Gallus gallus	103-113
23207768-7	2012	On the other hand, CAQ-mediated stabilization of HIF-1alpha is reversed by Fe(2+) but not by Zn(2+).	Iron	75-77	hypoxia inducible factor 1 alpha subunit	Gallus gallus	49-59
22325451-1	2012	OBJECTIVES: Heme oxygenase-1 (HO-1) which degrades Heme to free iron, biliverdin and carbon monoxide (CO) plays an important role in inflammation.	Iron	64-68	heme oxygenase 1	Mus musculus	12-28
22325451-1	2012	OBJECTIVES: Heme oxygenase-1 (HO-1) which degrades Heme to free iron, biliverdin and carbon monoxide (CO) plays an important role in inflammation.	Iron	64-68	heme oxygenase 1	Mus musculus	30-34
23320053-10	2012	Anemia with functional iron deficiency (transferrin saturation &lt;20%) should be treated with intravenous iron, as oral iron is ineffective being not absorbed.	Iron	23-27	transferrin	Homo sapiens	40-51
23046645-0	2012	Transferrin-mediated cellular iron delivery.	Iron	30-34	transferrin	Homo sapiens	0-11
23046645-1	2012	Essential to iron homeostasis is the transport of iron by the bilobal protein human serum transferrin (hTF).	Iron	13-17	transferrin	Homo sapiens	90-101
23046645-1	2012	Essential to iron homeostasis is the transport of iron by the bilobal protein human serum transferrin (hTF).	Iron	50-54	transferrin	Homo sapiens	90-101
23046654-10	2012	Several human pathologies may result from defects in Nramp-dependent Fe(2+) or Mn(2+) transport, including iron overload, neurodegenerative diseases and innate susceptibility to infectious diseases.	Iron	69-71	solute carrier family 11 member 1	Homo sapiens	53-58
23046654-10	2012	Several human pathologies may result from defects in Nramp-dependent Fe(2+) or Mn(2+) transport, including iron overload, neurodegenerative diseases and innate susceptibility to infectious diseases.	Iron	107-111	solute carrier family 11 member 1	Homo sapiens	53-58
22969838-5	2012	The iron-mediated oxidative stress occurs due to repeated hemorrhage in endometriosis, then this compound oxidatively modifies genomic DNA and, subsequently, ER depletion may be observed.	Iron	4-8	estrogen receptor 1	Homo sapiens	158-160
23019066-5	2012	Plastically expressed genes included both genes regulated directly by copper-binding transcription factors Mac1 and Ace1 and genes indirectly responding to the downstream metabolic consequences of the copper gradient, particularly genes involved in copper, iron, and sulfur homeostasis.	Iron	257-261	Mac1p	Saccharomyces cerevisiae S288C	107-111
22284696-13	2012	In conclusion, IL-6, but not CRP, is a strong predictor of ESA hyporesponsiveness in hemodialysis patients who have sufficient iron.	Iron	127-131	interleukin 6	Homo sapiens	15-19
22652723-0	2012	Maximizing the erythropoietin response: iron strategies.	Iron	40-44	erythropoietin	Homo sapiens	15-29
23339309-4	2012	In Alzheimer"s disease, it is thought that metals (mostly Cu, Fe and heme) can bind to amyloid-beta and that such systems are involved in the generation of oxidative stress.	Iron	62-64	amyloid beta precursor protein	Homo sapiens	87-99
23320053-10	2012	Anemia with functional iron deficiency (transferrin saturation &lt;20%) should be treated with intravenous iron, as oral iron is ineffective being not absorbed.	Iron	107-111	transferrin	Homo sapiens	40-51
22009034-4	2012	Confocal microscopy showed that LfR is expressed and localized at the plasma membrane of mouse crypt cells isolated from 7 to 10 days old pups, specifically binding both iron-free Lf (apo-Lf) and iron-saturated Lf (holo-Lf).	Iron	170-174	intelectin 1 (galactofuranose binding)	Mus musculus	32-35
22168577-13	2012	The key inflammatory regulators IL-1beta and NFkappaB were inhibited in the presence of surface-complexed Fe possibly through decreased ERK signaling upstream of the NALP3 inflammasome.	Iron	106-108	interleukin 1 beta	Rattus norvegicus	32-40
22168577-13	2012	The key inflammatory regulators IL-1beta and NFkappaB were inhibited in the presence of surface-complexed Fe possibly through decreased ERK signaling upstream of the NALP3 inflammasome.	Iron	106-108	Eph receptor B1	Rattus norvegicus	136-139
22009034-4	2012	Confocal microscopy showed that LfR is expressed and localized at the plasma membrane of mouse crypt cells isolated from 7 to 10 days old pups, specifically binding both iron-free Lf (apo-Lf) and iron-saturated Lf (holo-Lf).	Iron	196-200	intelectin 1 (galactofuranose binding)	Mus musculus	32-35
22616033-1	2012	Gallium-67 localization is based on the fact that it binds to plasma proteins like transferrin and lactoferrin, which have iron-binding sites.	Iron	123-127	transferrin	Homo sapiens	83-94
22387411-0	2012	From anti-Parkinson"s drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer"s disease.	Iron	59-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99
22906273-7	2012	Serum  iron, ferritin, transferrin and transferrin saturation were significantly higher in patients with, versus those without, hepatic iron deposition.	Iron	136-140	transferrin	Homo sapiens	39-50
21605201-2	2012	The aim of this study was to test the hypothesis that elevated transferrin saturation levels (as a proxy for iron overload) and haemochromatosis genotype C282Y/C282Y are associated with an increased risk of cancer.	Iron	109-113	transferrin	Homo sapiens	63-74
22894091-1	2012	The removal of As(III) and As(V) from aqueous solution was investigated using waste cast iron, which is a byproduct of the iron casting process in foundries.	Iron	89-93	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-32
22239127-8	2012	Two iron foundries had significantly higher quartz concentration levels than the others (beta = 1.31; 95% CI 1.00-1.71 and beta = 1.63; 95% CI 1.00-2.65, respectively).	Iron	4-8	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	89-97
22239127-8	2012	Two iron foundries had significantly higher quartz concentration levels than the others (beta = 1.31; 95% CI 1.00-1.71 and beta = 1.63; 95% CI 1.00-2.65, respectively).	Iron	4-8	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	123-131
22000712-5	2012	We hypothesize that treatment with TNF-alpha antagonists predisposes the patient to infections and neoplasms by reversing the sequestration of host iron mediated by the cytokine and increasing available concentrations of this metal.	Iron	148-152	tumor necrosis factor	Homo sapiens	35-44
22000712-7	2012	Furthermore, it is predicted that alternative attempts to treat inflammatory diseases by blocking other pivotal cytokines that also participate in iron homeostasis (e.g. IFN-gamma, IL-1, and IL-6) will similarly be associated with infections and neoplastic complications.	Iron	147-151	interferon gamma	Homo sapiens	170-179
22156453-0	2012	Novel therapeutic approach for neurodegenerative pathologies: multitarget iron-chelating drugs regulating hypoxia-inducible factor 1 signal transduction pathway.	Iron	74-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-132
22121980-4	2012	This review will explore the role and reported changes in metal ions in Alzheimer disease, particularly the brain, blood and cerebral spinal fluid, emphasizing how iron, copper and zinc may be involved through the interactions with amyloid precursor protein, the proteolytically cleaved peptide amyloid-beta (Abeta), and other related metalloproteins.	Iron	164-168	amyloid beta precursor protein	Homo sapiens	232-257
22121980-4	2012	This review will explore the role and reported changes in metal ions in Alzheimer disease, particularly the brain, blood and cerebral spinal fluid, emphasizing how iron, copper and zinc may be involved through the interactions with amyloid precursor protein, the proteolytically cleaved peptide amyloid-beta (Abeta), and other related metalloproteins.	Iron	164-168	amyloid beta precursor protein	Homo sapiens	295-307
22121980-4	2012	This review will explore the role and reported changes in metal ions in Alzheimer disease, particularly the brain, blood and cerebral spinal fluid, emphasizing how iron, copper and zinc may be involved through the interactions with amyloid precursor protein, the proteolytically cleaved peptide amyloid-beta (Abeta), and other related metalloproteins.	Iron	164-168	amyloid beta precursor protein	Homo sapiens	309-314
23075669-5	2012	Participants with ferritin &gt;=1,000 microg/l or transferrin iron saturation (TSAT) &gt;=50% at screening were excluded.	Iron	62-66	transferrin	Homo sapiens	50-61
22156453-3	2012	An additional neuroprotective mechanism of iron-chelating compounds is associated with their ability to regulate the transcriptional activator hypoxia-inducible factor 1 (HIF-1).	Iron	43-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-169
22156453-3	2012	An additional neuroprotective mechanism of iron-chelating compounds is associated with their ability to regulate the transcriptional activator hypoxia-inducible factor 1 (HIF-1).	Iron	43-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-176
23236296-4	2012	Fine-scale mapping showed that a variant of the Fe homeostasis-related FERRIC REDUCTASE DEFECTIVE3 (FRD3) gene, which encodes a multidrug and toxin efflux (MATE) transporter, is responsible for reduced Zn tolerance in A. thaliana.	Iron	48-50	MATE efflux family protein	Arabidopsis thaliana	71-98
25762976-6	2012	These are likely to include the effects of (a) increased amounts of absorbed iron, with the production of plasma non-transferrin-bound iron, (b) increased amounts of iron in the gastrointestinal tract, with effects on gastrointestinal structural integrity and on gut microflora, and (c) the complex immune effects of iron interventions.	Iron	77-81	transferrin	Homo sapiens	117-128
25762976-6	2012	These are likely to include the effects of (a) increased amounts of absorbed iron, with the production of plasma non-transferrin-bound iron, (b) increased amounts of iron in the gastrointestinal tract, with effects on gastrointestinal structural integrity and on gut microflora, and (c) the complex immune effects of iron interventions.	Iron	135-139	transferrin	Homo sapiens	117-128
25762976-6	2012	These are likely to include the effects of (a) increased amounts of absorbed iron, with the production of plasma non-transferrin-bound iron, (b) increased amounts of iron in the gastrointestinal tract, with effects on gastrointestinal structural integrity and on gut microflora, and (c) the complex immune effects of iron interventions.	Iron	135-139	transferrin	Homo sapiens	117-128
25762976-6	2012	These are likely to include the effects of (a) increased amounts of absorbed iron, with the production of plasma non-transferrin-bound iron, (b) increased amounts of iron in the gastrointestinal tract, with effects on gastrointestinal structural integrity and on gut microflora, and (c) the complex immune effects of iron interventions.	Iron	135-139	transferrin	Homo sapiens	117-128
22577491-8	2012	Regarding the inter-individual relationships among serum redox statuses and dietary nutrient intakes, significant correlations were noted in CAT versus carbohydrates, protein, magnesium, and manganese; GSH versus carbohydrates, protein, fat, selenium, zinc, iron, and magnesium; XO versus cholesterol; CAT versus GSH.	Iron	258-262	catalase	Homo sapiens	141-144
22111666-0	2012	Iron levels found in hemochromatosis patients inhibit gamma-thrombin-induced platelet aggregation.	Iron	0-4	coagulation factor II, thrombin	Homo sapiens	60-68
22111666-4	2012	While performing platelet aggregation studies on hemochromatotic blood samples, it was discovered that the increased serum iron levels associated with this disease almost completely inhibited gamma-thrombin-induced platelet aggregation.	Iron	123-127	coagulation factor II, thrombin	Homo sapiens	198-206
22111666-5	2012	Further studies were conducted with samples derived from control and hemochromatotic individuals to determine the effects of iron on both alpha- and gamma-thrombin-induced platelet aggregations.	Iron	125-129	coagulation factor II, thrombin	Homo sapiens	155-163
22111666-6	2012	It was found that gamma-thrombin-induced platelet aggregations were strongly inhibited by the direct binding of iron to these enzymes.	Iron	112-116	coagulation factor II, thrombin	Homo sapiens	24-32
22111666-8	2012	gamma-Thrombin activity was significantly more sensitive to toxic levels of iron than alpha-thrombin in the activation of the PAR receptors.	Iron	76-80	coagulation factor II, thrombin	Homo sapiens	6-14
22111666-11	2012	It is unknown, at this time, what specific clinical implications iron inhibition of gamma-thrombin may have, but it is very possible that other conditions caused by hemochromatosis could be exacerbated by the inability of platelets to aggregate normally.	Iron	65-69	coagulation factor II, thrombin	Homo sapiens	90-98
22396654-8	2012	ftn-1 expression is induced by exposure to iron, and we found that hif-1 was required for this induction.	Iron	43-47	Hypoxia-inducible factor 1	Caenorhabditis elegans	67-72
23236296-0	2012	Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Zn tolerance in Arabidopsis thaliana.	Iron	80-82	MATE efflux family protein	Arabidopsis thaliana	25-29
23236296-4	2012	Fine-scale mapping showed that a variant of the Fe homeostasis-related FERRIC REDUCTASE DEFECTIVE3 (FRD3) gene, which encodes a multidrug and toxin efflux (MATE) transporter, is responsible for reduced Zn tolerance in A. thaliana.	Iron	48-50	MATE efflux family protein	Arabidopsis thaliana	100-104
23227165-9	2012	These iron-induced changes were significantly attenuated by the co-treatment of HAECs with N-acetylcysteine and inhibitors of NADPH oxidase, nuclear factor kappaB, and activator protein-1.	Iron	6-10	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-187
23209633-7	2012	Analyses of gut mucus showed that CAT4 hyperexcreted enterobactin in vivo, effectively rendering the catecholate transport-deficient strain iron-starved.	Iron	140-144	dominant cataract 4	Mus musculus	34-38
23082224-5	2012	Increasing the abundance of the heart-specific isoform III significantly increased the mitochondrial aconitase activity, while over-expression of the cerebellum-specific isoform II protected against oxidative damage of Fe-S cluster-containing aconitase.	Iron	219-223	aconitase 2	Homo sapiens	87-110
23152779-5	2012	Increases in serum iron levels following MNP injection were accompanied by increases in the level of transferrin in the serum and the number of circulating red blood cells.	Iron	19-23	transferrin	Homo sapiens	101-112
23029472-8	2012	The preferential binding of HJV for BMP6 is consistent with the functional role of HJV and BMP6 in regulating systemic iron homeostasis.	Iron	119-123	bone morphogenetic protein 6	Homo sapiens	36-40
23029472-8	2012	The preferential binding of HJV for BMP6 is consistent with the functional role of HJV and BMP6 in regulating systemic iron homeostasis.	Iron	119-123	bone morphogenetic protein 6	Homo sapiens	91-95
23024788-8	2012	CONCLUSION: This study suggests that ALS patients may have increased iron storage, as measured by increased serum ferritin and TSC.	Iron	69-73	TSC complex subunit 1	Homo sapiens	127-130
22957037-1	2012	Transferrin (TF) is a protein that plays a central role in iron metabolism.	Iron	59-63	transferrin	Homo sapiens	0-11
22957037-1	2012	Transferrin (TF) is a protein that plays a central role in iron metabolism.	Iron	59-63	transferrin	Homo sapiens	13-15
22957037-11	2012	One site was located in the cleft between the N1 and N2 domains and was expected to affect the capability of TF to bind to or release iron indirectly.	Iron	134-138	transferrin	Homo sapiens	109-111
22957037-13	2012	Two of these sites, which could have evolved from the competition for iron between pathogenic bacteria and TF, were located in potential pathogen-binding domains.	Iron	70-74	transferrin	Homo sapiens	107-109
22761678-5	2012	A novel SNP rs1421312 in TMPRSS6 was associated with serum iron in whites (p = 3.7 x 10(-6)) and replicated in African Americans (p = 0.0012).Twenty SNPs in the TF gene region were associated with total iron-binding capacity in whites (p&lt;4.4 x 10(-5)); six SNPs replicated in other ethnicities (p&lt;0.01).	Iron	59-63	transmembrane serine protease 6	Homo sapiens	25-32
22723983-0	2012	TGF-beta and iron differently alter HBV replication in human hepatocytes through TGF-beta/BMP signaling and cellular microRNA expression.	Iron	13-17	transforming growth factor beta 1	Homo sapiens	81-89
22723983-4	2012	We found iron and TGF-beta increased hepcidin mRNA expression or TGF-beta receptor kinase activity, respectively, which indicated that 2.2.15 cells responded appropriately to these substances.	Iron	9-13	transforming growth factor beta 1	Homo sapiens	65-73
22723983-13	2012	We surmised that TGF-beta/BMP pathway members, i.e., SMADs, likely governed iron or TGF-beta-induced microRNA expression.	Iron	76-80	transforming growth factor beta 1	Homo sapiens	17-25
22761678-5	2012	A novel SNP rs1421312 in TMPRSS6 was associated with serum iron in whites (p = 3.7 x 10(-6)) and replicated in African Americans (p = 0.0012).Twenty SNPs in the TF gene region were associated with total iron-binding capacity in whites (p&lt;4.4 x 10(-5)); six SNPs replicated in other ethnicities (p&lt;0.01).	Iron	203-207	transmembrane serine protease 6	Homo sapiens	25-32
22509377-1	2012	BACKGROUND: Iron-refractory iron deficiency anaemia (IRIDA) is a rare disorder which was linked to mutations in two genes (SLC11A2 and TMPRSS6).	Iron	12-16	transmembrane serine protease 6	Homo sapiens	135-142
22666436-3	2012	We hypothesized that the increase of iron through a NF-kappaB-regulated 1B isoform of the divalent metal transporter-1 (1B/DMT1) might contribute to post-ischemic neuronal damage.	Iron	37-41	nuclear factor kappa B subunit 1	Homo sapiens	52-61
22666436-11	2012	Our data showed that 1B/(-)IRE DMT1 expression and intracellular iron influx are early downstream responses to NF-kappaB/RelA activation and acetylation during brain ischemia and contribute to the pathogenesis of stroke-induced neuronal damage.	Iron	65-69	nuclear factor kappa B subunit 1	Homo sapiens	111-120
22675442-0	2012	Tumor necrosis factor alpha inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis.	Iron	55-59	tumor necrosis factor	Mus musculus	0-27
22509377-9	2012	Six SAPHIR participants carrying the same TMPRSS6 genotypes and haplotype-pairs as one anaemic son showed lower ferritin and iron levels than the average.	Iron	125-129	transmembrane serine protease 6	Homo sapiens	42-49
22509377-10	2012	One individual exhibiting the joint SLC11A2/TMPRSS6 profile of the anaemic son had iron and ferritin levels lying below the 5(th) percentile of the population"s iron and ferritin level distribution.	Iron	83-87	transmembrane serine protease 6	Homo sapiens	44-51
22509377-10	2012	One individual exhibiting the joint SLC11A2/TMPRSS6 profile of the anaemic son had iron and ferritin levels lying below the 5(th) percentile of the population"s iron and ferritin level distribution.	Iron	161-165	transmembrane serine protease 6	Homo sapiens	44-51
22715660-5	2012	RESULTS: Group 1 patients had a significantly lower, mean level of iron in the blood and transferrin saturation with iron while the other parameters of iron metabolism (TIBC, LIBC, transferrin, ferritin) did not significantly differ from these of group 2.	Iron	117-121	transferrin	Homo sapiens	89-100
22101801-0	2012	Preparation and investigation of bioactive transferrin-iron complexes formed with different synergistic anions.	Iron	55-59	transferrin	Homo sapiens	43-54
22101801-4	2012	The electropherograms show the differences between iron-free- and iron-complexed molecular forms of human serum transferrin.	Iron	51-55	transferrin	Homo sapiens	112-123
22101801-4	2012	The electropherograms show the differences between iron-free- and iron-complexed molecular forms of human serum transferrin.	Iron	66-70	transferrin	Homo sapiens	112-123
22101801-5	2012	The iron-complexed transferrin sample containing the different anions as synergistic complexing agents were characterized by different electrophoretic parameters.	Iron	4-8	transferrin	Homo sapiens	19-30
23196478-5	2012	Transferrin-bound iron (Tf-Fe(3+)) binds to the transferrin receptor 1 (TR1) on the luminal membrane of the endothelial cells, and then Tf-Fe(3+)-TR1 complex is internalized in the endosomes.	Iron	18-22	transferrin	Homo sapiens	0-11
23049400-3	2012	OBJECTIVE: The aim of this study was to estimate the frequency of the GSTM1 and GSTT1 genotypes in sickle cell disease patients and their effect on iron status.	Iron	148-152	glutathione S-transferase mu 1	Homo sapiens	70-75
23256035-0	2012	Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe.	Iron	0-4	transferrin	Homo sapiens	35-46
22715660-5	2012	RESULTS: Group 1 patients had a significantly lower, mean level of iron in the blood and transferrin saturation with iron while the other parameters of iron metabolism (TIBC, LIBC, transferrin, ferritin) did not significantly differ from these of group 2.	Iron	117-121	transferrin	Homo sapiens	89-100
22018865-6	2011	Our batch experiments demonstrated that CMC-stabilized Pd/Fe nanoparticles (0.6 g Fe L(-1)) were able to remove much higher levels of 2,4-D with only one intermediate 2-chlorophenoxyacetic acid (2-CPA) and the final organic product phenoxyacetic acid (PA), than non-stabilized Pd/Fe nanoparticles or microsized Pd/Fe particles.	Iron	58-60	carboxypeptidase A1	Homo sapiens	197-200
22088162-4	2011	Gene expression studies reveal a large induction of the YS1 transporter in leaves and severe repression of an iron acquisition gene DMAS1 in roots, suggesting significant alterations in the iron homeostatic mechanisms in transgenic lpa1-1.	Iron	110-114	deoxymugineic acid synthase 1	Zea mays	132-137
22138393-1	2011	HIF-1alpha plays a key role in iron uptake and transport in the liver, whose activity is tightly linked to the repression of hepcidin (Hamp).	Iron	31-35	hepcidin antimicrobial peptide	Rattus norvegicus	125-133
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Iron	120-124	interleukin 1 beta	Mus musculus	167-175
22138393-1	2011	HIF-1alpha plays a key role in iron uptake and transport in the liver, whose activity is tightly linked to the repression of hepcidin (Hamp).	Iron	31-35	hepcidin antimicrobial peptide	Rattus norvegicus	135-139
22138393-2	2011	Hamp prevents intestinal iron uptake and cellular efflux by negatively modulating ferroportin.	Iron	25-29	hepcidin antimicrobial peptide	Rattus norvegicus	0-4
22138393-9	2011	These data demonstrate EGCG"s therapeutic potential in modulating hepcidin expression in diseases associated with altered iron metabolism.	Iron	122-126	hepcidin antimicrobial peptide	Rattus norvegicus	66-74
22547187-10	2011	Apparently, increases in unsaturated and total iron binding capacity and serum transferrin values seen amongst our subjects with increasing gestation may perhaps be a mechanism to ensure a fetal adequate iron delivery on account of the decreasing serum iron concentration with gestation in our subjects.	Iron	204-208	transferrin	Homo sapiens	79-90
22547187-10	2011	Apparently, increases in unsaturated and total iron binding capacity and serum transferrin values seen amongst our subjects with increasing gestation may perhaps be a mechanism to ensure a fetal adequate iron delivery on account of the decreasing serum iron concentration with gestation in our subjects.	Iron	204-208	transferrin	Homo sapiens	79-90
21274654-8	2011	Since alterations in iron levels in the brain are causally linked to degenerative conditions such as Alzheimer"s disease, an improved understanding of the regulation of iron transport protein expression such as FPN1, DMT1, and CP could lead to novel strategies for treatments.	Iron	169-173	solute carrier family 40 member 1	Rattus norvegicus	211-215
21987576-1	2011	Most eukaryotes contain iron-sulfur cluster (ISC) assembly proteins related to Saccharomyces cerevisiae Isa1 and Isa2.	Iron	24-28	Isa2p	Saccharomyces cerevisiae S288C	113-117
21987576-7	2011	Isa1 and Isa2 proteins are shown to bind iron in vivo, yet the Isa1-Isa2-bound iron was not needed as a donor for de novo assembly of the [2Fe-2S] cluster on the general Fe/S scaffold proteins Isu1-Isu2.	Iron	79-83	iron-sulfur cluster assembly enzyme	Homo sapiens	198-202
22021369-0	2011	Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.	Iron	138-142	transferrin	Homo sapiens	120-131
22021369-7	2011	The increased concentrations of non-transferrin-bound iron correlated with enhanced proliferation in vitro of a pathogenic strain of Escherichia coli (r = 0.94, P = .002).	Iron	54-58	transferrin	Homo sapiens	36-47
22021369-8	2011	Therefore, circulating non-transferrin-bound iron derived from rapid clearance of transfused, older stored RBCs may enhance transfusion-related complications, such as infection.	Iron	45-49	transferrin	Homo sapiens	27-38
22159112-5	2011	In primary microglial cultures, administration of iron chelator deferoxamine reduced the generation of iron-induced reactive oxygen and nitrogen species and proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta.	Iron	50-54	tumor necrosis factor	Rattus norvegicus	191-218
22159112-5	2011	In primary microglial cultures, administration of iron chelator deferoxamine reduced the generation of iron-induced reactive oxygen and nitrogen species and proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta.	Iron	50-54	interleukin 1 beta	Rattus norvegicus	223-240
22159112-5	2011	In primary microglial cultures, administration of iron chelator deferoxamine reduced the generation of iron-induced reactive oxygen and nitrogen species and proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta.	Iron	103-107	tumor necrosis factor	Rattus norvegicus	191-218
22159112-5	2011	In primary microglial cultures, administration of iron chelator deferoxamine reduced the generation of iron-induced reactive oxygen and nitrogen species and proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta.	Iron	103-107	interleukin 1 beta	Rattus norvegicus	223-240
21931161-4	2011	Here, we present evidence supporting the model that beta" is required for iron loading and Tyr( ) formation in beta in vivo via a pathway that is likely dependent on the cytosolic monothiol glutaredoxins Grx3/Grx4 and the Fe-S cluster protein Dre2.	Iron	74-78	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	209-213
21931161-4	2011	Here, we present evidence supporting the model that beta" is required for iron loading and Tyr( ) formation in beta in vivo via a pathway that is likely dependent on the cytosolic monothiol glutaredoxins Grx3/Grx4 and the Fe-S cluster protein Dre2.	Iron	74-78	electron carrier DRE2	Saccharomyces cerevisiae S288C	243-247
22071701-0	2011	Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants.	Iron	11-15	erythropoietin	Homo sapiens	60-74
22071701-9	2011	Erythropoietin was initially similar between groups but decreased significantly in iron-supplemented infants.	Iron	83-87	erythropoietin	Homo sapiens	0-14
22071701-12	2011	Erythropoietin is negatively correlated with iron status, which suggests a feedback mechanism that needs further study.	Iron	45-49	erythropoietin	Homo sapiens	0-14
22435157-10	2011	Bacterial strains (B-21) appeared a good uptake of heavy metal ions (copper, cadmium, iron, cadmium and Lead) than other bacterial strains.	Iron	86-90	cytohesin 1	Homo sapiens	19-23
21967884-0	2011	Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin.	Iron	106-110	cytochrome c, somatic	Homo sapiens	69-81
21967884-6	2011	Altogether the resulting data suggest that nitration of tyrosines 46 and 48 makes Cc easily degradable upon turning the heme iron state to high-spin.	Iron	125-129	cytochrome c, somatic	Homo sapiens	82-84
21359624-6	2011	Increased iron absorption reported in early hypoxia could be accounted for in part by the enhancement of Dcytb expression by Hif-2alpha in the duodenum.	Iron	10-14	cytochrome b reductase 1	Mus musculus	105-110
21939754-3	2011	After blood-brain barrier disruption, CNS cells may be exposed to plasma concentrations of transferrin-bound iron (TBI), which exceed that in the CSF by over 50-fold.	Iron	109-113	transferrin	Homo sapiens	91-102
21939754-8	2011	After treatment with (55)Fe-transferrin, approximately 40% of cell iron was exported within 16h.	Iron	67-71	transferrin	Homo sapiens	28-39
21859731-1	2011	BACKGROUND: Increased levels of hepcidin, the master regulator of iron homeostasis, contribute to the diversion of iron underlying the anemia of chronic disease.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	32-40
21859731-1	2011	BACKGROUND: Increased levels of hepcidin, the master regulator of iron homeostasis, contribute to the diversion of iron underlying the anemia of chronic disease.	Iron	115-119	hepcidin antimicrobial peptide	Rattus norvegicus	32-40
21859731-6	2011	RESULTS: SMAD1/5/8 phosphorylation and in parallel hepcidin mRNA expression were increased in anemia of chronic disease but significantly down-regulated in anemia of chronic disease with concomitant iron deficiency, either on the basis of phlebotomy or dietary iron restriction.	Iron	199-203	hepcidin antimicrobial peptide	Rattus norvegicus	51-59
21859731-8	2011	Reduced SMAD1/5/8 activity in association with phlebotomy was paralleled by increased expression of the inhibitory factor, SMAD7, dietary iron restriction appeared to impair hepcidin transactivating SMAD pathways via reduction of membrane bound hemojuvelin expression.	Iron	138-142	SMAD family member 7	Rattus norvegicus	123-128
21859731-8	2011	Reduced SMAD1/5/8 activity in association with phlebotomy was paralleled by increased expression of the inhibitory factor, SMAD7, dietary iron restriction appeared to impair hepcidin transactivating SMAD pathways via reduction of membrane bound hemojuvelin expression.	Iron	138-142	hepcidin antimicrobial peptide	Rattus norvegicus	174-182
21963450-7	2011	Among the major cytokines, IL-6 is an important signalling molecule, which also regulates iron homeostasis in response to an inflammatory situation.	Iron	90-94	interleukin 6	Mus musculus	27-31
21850523-8	2011	These data suggest that CYP2E1 enhances H(2)S-dependent cytotoxicity in HepG2 cells through the generation of iron-dependent oxidative stress and lipid peroxidation.	Iron	110-114	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	24-30
21913989-11	2011	Low total hemoglobin and high non-transferrin-bound iron levels independently characterized patients with evidence of stenosis on MRA.	Iron	52-56	transferrin	Homo sapiens	34-45
20607588-7	2011	Moreover, pretreatment of HCT116 cells with the iron chelator deferoxamine mesylate salt (DFO) abrogated induction of GRP78 and GADD153 upon DHA treatment, indicating iron is required for DHA-induced ER stress.	Iron	48-52	heat shock protein family A (Hsp70) member 5	Homo sapiens	118-123
20607588-7	2011	Moreover, pretreatment of HCT116 cells with the iron chelator deferoxamine mesylate salt (DFO) abrogated induction of GRP78 and GADD153 upon DHA treatment, indicating iron is required for DHA-induced ER stress.	Iron	48-52	DNA damage inducible transcript 3	Homo sapiens	128-135
20607588-7	2011	Moreover, pretreatment of HCT116 cells with the iron chelator deferoxamine mesylate salt (DFO) abrogated induction of GRP78 and GADD153 upon DHA treatment, indicating iron is required for DHA-induced ER stress.	Iron	167-171	heat shock protein family A (Hsp70) member 5	Homo sapiens	118-123
22041858-1	2011	Serum transferrin (Tf) is an iron binding glycoprotein that plays a central role in the metabolism of this essential metal but it also binds other metal ions.	Iron	29-33	transferrin	Homo sapiens	6-17
22041858-1	2011	Serum transferrin (Tf) is an iron binding glycoprotein that plays a central role in the metabolism of this essential metal but it also binds other metal ions.	Iron	29-33	transferrin	Homo sapiens	19-21
22041858-2	2011	Four main transferrin forms containing different iron binding states can be distinguished in human serum samples: monoferric (C-site or N-site), holotransferrin (with two Fe atoms) and apotransferrin (with no metal).	Iron	49-53	transferrin	Homo sapiens	10-21
22041858-2	2011	Four main transferrin forms containing different iron binding states can be distinguished in human serum samples: monoferric (C-site or N-site), holotransferrin (with two Fe atoms) and apotransferrin (with no metal).	Iron	171-173	transferrin	Homo sapiens	10-21
22194696-0	2011	HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.	Iron	16-20	Hypoxia-inducible factor 1	Caenorhabditis elegans	0-5
21715234-9	2011	Four months after the iron infusion 10 patients had a blood ferritin level higher than 100mug/L and a transferrin saturation higher than 20%.	Iron	22-26	transferrin	Homo sapiens	102-113
22194696-1	2011	Caenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine.	Iron	57-61	Ferritin	Caenorhabditis elegans	33-38
22194696-1	2011	Caenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine.	Iron	57-61	Ferritin	Caenorhabditis elegans	78-86
22194696-2	2011	Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown.	Iron	95-99	Ferritin	Caenorhabditis elegans	146-151
22194696-8	2011	We show that hif-1 null worms grown under iron limiting conditions are developmentally delayed and that depletion of FTN-1 and FTN-2 rescues this phenotype.	Iron	42-46	Hypoxia-inducible factor 1	Caenorhabditis elegans	13-18
22194696-9	2011	These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.	Iron	48-52	Hypoxia-inducible factor 1	Caenorhabditis elegans	21-26
22194696-9	2011	These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.	Iron	72-76	Hypoxia-inducible factor 1	Caenorhabditis elegans	21-26
21978585-0	2011	Reduction of As(V) to As(III) by commercial ZVI or As(0) with acid-treated ZVI.	Iron	44-47	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	13-18
21862411-4	2011	By contrast, genetically enhanced hepcidin production, as observed in matriptase-2 deficiency, generates iron-refractory iron deficiency anemia.	Iron	105-109	transmembrane serine protease 6	Homo sapiens	70-82
21978585-0	2011	Reduction of As(V) to As(III) by commercial ZVI or As(0) with acid-treated ZVI.	Iron	75-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	13-18
21978585-7	2011	As(V) reactions with ZVI were also fast and no lag phase was observed which was contrary to previous reports.	Iron	21-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
21978585-8	2011	Commercial ZVI reduced As(V) to As(III) only when As(V) was adsorbed, i.e., for pH&lt;7.	Iron	11-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
21978585-8	2011	Commercial ZVI reduced As(V) to As(III) only when As(V) was adsorbed, i.e., for pH&lt;7.	Iron	11-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-55
21978585-10	2011	Acid-treated ZVI reduced As(V) to As(0), shown using wet chemical analyses and XANES/EXAFS.	Iron	13-16	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	25-30
22373344-0	2011	Effect of iron sources on the glycosylation macroheterogeneity of human recombinant IFN-gamma produced by CHO cells during batch processes.	Iron	10-14	interferon gamma	Homo sapiens	84-93
21992268-1	2011	Cysteine dioxygenase (CDO) is a non-heme mononuclear iron enzyme that catalyzes the O(2)-dependent oxidation of L-cysteine (Cys) to produce cysteine sulfinic acid (CSA).	Iron	53-57	cell adhesion associated, oncogene regulated	Homo sapiens	22-25
21730356-3	2011	This reticuloendothelial iron sequestration is primarily mediated by excess levels of the iron regulatory peptide hepcidin down-regulating the functional expression of the only known cellular iron export protein ferroportin resulting in blockade of iron egress from these cells.	Iron	25-29	hepcidin antimicrobial peptide	Rattus norvegicus	114-122
21971825-4	2011	GATA- and its co-factor Friend of GATA (FOG) modulate the tissue-specific transcription of other genes involved in the metabolism of iron.	Iron	133-137	zinc finger protein, FOG family member 1	Homo sapiens	24-38
21971825-4	2011	GATA- and its co-factor Friend of GATA (FOG) modulate the tissue-specific transcription of other genes involved in the metabolism of iron.	Iron	133-137	zinc finger protein, FOG family member 1	Homo sapiens	40-43
21678945-2	2011	However, the interaction mode between iron ions and beta-amyloid peptide as well as their precise affinity is unknown.	Iron	38-42	amyloid beta precursor protein	Homo sapiens	52-72
21678945-9	2011	Finally, calculations of standard reduction potentials indicate that phenol coordination reduces the redox activity of the iron/Abeta complexes.	Iron	123-127	amyloid beta precursor protein	Homo sapiens	128-133
21777202-3	2011	To test this hypothesis, in the present study we used a genetic screen looking for yeast mutants that are synthetically lethal with the mitochondrial iron carriers Mrs3 and Mrs4.	Iron	150-154	Fe(2+) transporter	Saccharomyces cerevisiae S288C	164-168
21945528-3	2011	We were able to experimentally confirm a role of Fdx1 in the iron-sulfur cluster biosynthesis by in vitro reduction studies with cluster-loaded So ce56 IscU and by transfer studies of the cluster from the latter protein to apo-aconitase A.	Iron	61-65	iron-sulfur cluster assembly enzyme	Homo sapiens	152-156
22082307-7	2011	The nanoparticle discussed in this review, is a twin nanoparticle of iron coated with gold, which targets VEGF positive cell in the vicinity of cancer stem cell.	Iron	69-73	vascular endothelial growth factor A	Homo sapiens	106-110
21925516-8	2011	SIGNIFICANCE: Cholestasis-induced increase in plasma and decrease in hepatic iron levels were associated with up-regulation of liver HO-1 and ferroportin 1.	Iron	77-81	solute carrier family 40 member 1	Rattus norvegicus	142-155
21736448-3	2011	Optimal iron treatment is important for the optimal EPO effect.	Iron	8-12	erythropoietin	Homo sapiens	52-55
21736448-13	2011	CONCLUSION: In iron-replete haemodialysis patients the same EPO dose given intravenously is just as effective as given subcutaneously.	Iron	15-19	erythropoietin	Homo sapiens	60-63
22077971-4	2011	Homozygosity mapping revealed a perfectly overlapping homozygous region of 1.24 Mb corresponding to chromosome 2 and led to the identification of a homozygous missense mutation (c.622G &gt; T) in NFU1, which encodes a conserved protein suggested to participate in Fe-S cluster biogenesis.	Iron	264-268	Nfu1p	Saccharomyces cerevisiae S288C	196-200
22077971-10	2011	In contrast, depletion of the general Fe-S scaffold protein ISCU severely affected assembly of all tested Fe-S proteins, suggesting that NFU1 performs a specific function in mitochondrial Fe-S cluster maturation.	Iron	38-42	Nfu1p	Saccharomyces cerevisiae S288C	137-141
22077971-10	2011	In contrast, depletion of the general Fe-S scaffold protein ISCU severely affected assembly of all tested Fe-S proteins, suggesting that NFU1 performs a specific function in mitochondrial Fe-S cluster maturation.	Iron	106-110	Nfu1p	Saccharomyces cerevisiae S288C	137-141
22077971-10	2011	In contrast, depletion of the general Fe-S scaffold protein ISCU severely affected assembly of all tested Fe-S proteins, suggesting that NFU1 performs a specific function in mitochondrial Fe-S cluster maturation.	Iron	106-110	Nfu1p	Saccharomyces cerevisiae S288C	137-141
21925516-5	2011	Ferroportin 1 expression was increased with a simultaneous reduction in intrahepatic iron concentration.	Iron	85-89	solute carrier family 40 member 1	Rattus norvegicus	0-13
21730356-3	2011	This reticuloendothelial iron sequestration is primarily mediated by excess levels of the iron regulatory peptide hepcidin down-regulating the functional expression of the only known cellular iron export protein ferroportin resulting in blockade of iron egress from these cells.	Iron	90-94	hepcidin antimicrobial peptide	Rattus norvegicus	114-122
21730356-3	2011	This reticuloendothelial iron sequestration is primarily mediated by excess levels of the iron regulatory peptide hepcidin down-regulating the functional expression of the only known cellular iron export protein ferroportin resulting in blockade of iron egress from these cells.	Iron	90-94	hepcidin antimicrobial peptide	Rattus norvegicus	114-122
21730356-3	2011	This reticuloendothelial iron sequestration is primarily mediated by excess levels of the iron regulatory peptide hepcidin down-regulating the functional expression of the only known cellular iron export protein ferroportin resulting in blockade of iron egress from these cells.	Iron	90-94	hepcidin antimicrobial peptide	Rattus norvegicus	114-122
21730356-5	2011	Pharmacologic inhibition of hepcidin expression results in mobilization of iron from the RES, stimulation of erythropoiesis and correction of anemia.	Iron	75-79	hepcidin antimicrobial peptide	Rattus norvegicus	28-36
22295624-4	2011	There were significant positive correlations (P &lt; 0.01) among PCB congener concentration in the storage site and the iron foundry samples.	Iron	120-124	pyruvate carboxylase	Homo sapiens	65-68
22055506-3	2011	We have identified the iron-dependent prolyl hydroxylases (PHDs) and asparaginyl hydroxylase (FIH1) that modify hypoxia-inducible factor alpha (HIFalpha) as targets of PCBP1.	Iron	23-27	poly(rC) binding protein 1	Homo sapiens	168-173
22055506-6	2011	These data indicated that PCBP1 was required for iron incorporation into PHD and suggest a broad role for PCBP1 and 2 in delivering iron to cytosolic nonheme iron enzymes.	Iron	49-53	poly(rC) binding protein 1	Homo sapiens	26-31
22055506-6	2011	These data indicated that PCBP1 was required for iron incorporation into PHD and suggest a broad role for PCBP1 and 2 in delivering iron to cytosolic nonheme iron enzymes.	Iron	132-136	poly(rC) binding protein 1	Homo sapiens	26-31
22055506-6	2011	These data indicated that PCBP1 was required for iron incorporation into PHD and suggest a broad role for PCBP1 and 2 in delivering iron to cytosolic nonheme iron enzymes.	Iron	132-136	poly(rC) binding protein 1	Homo sapiens	106-117
22055506-6	2011	These data indicated that PCBP1 was required for iron incorporation into PHD and suggest a broad role for PCBP1 and 2 in delivering iron to cytosolic nonheme iron enzymes.	Iron	132-136	poly(rC) binding protein 1	Homo sapiens	26-31
22055506-6	2011	These data indicated that PCBP1 was required for iron incorporation into PHD and suggest a broad role for PCBP1 and 2 in delivering iron to cytosolic nonheme iron enzymes.	Iron	132-136	poly(rC) binding protein 1	Homo sapiens	106-117
21871451-3	2011	To elucidate molecular mechanisms of efficient tumor progression under the hypoferric condition, we studied the roles of six-transmembrane epithelial antigen of the prostate family member 3 (STEAP3), which was reported to facilitate iron uptake.	Iron	233-237	STEAP3 metalloreductase	Homo sapiens	191-197
21871451-5	2011	The impact of STEAP3 expression was analyzed about the amount of iron storage, the survival under hypoferric conditions in vitro and the growth of tumor in vivo.	Iron	65-69	STEAP3 metalloreductase	Homo sapiens	14-20
21871451-6	2011	STEAP3 overexpression increased ferritin, an indicator of iron storage, in STEAP3-overexpressing Raji cells.	Iron	58-62	STEAP3 metalloreductase	Homo sapiens	0-6
21871451-7	2011	STEAP3 gave Raji cells the resistance to iron deprivation-induced apoptosis.	Iron	41-45	STEAP3 metalloreductase	Homo sapiens	0-6
21871451-11	2011	These findings indicate that STEAP3 maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition.	Iron	46-50	STEAP3 metalloreductase	Homo sapiens	29-35
22055506-0	2011	Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.	Iron	48-52	poly(rC) binding protein 1	Homo sapiens	64-69
22055506-0	2011	Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.	Iron	48-52	poly(rC) binding protein 2	Homo sapiens	74-79
22055506-2	2011	Human poly (rC) binding protein 1 (PCBP1) is an iron chaperone that binds iron and delivers it to ferritin, a cytosolic iron storage protein.	Iron	48-52	poly(rC) binding protein 1	Homo sapiens	35-40
22055506-2	2011	Human poly (rC) binding protein 1 (PCBP1) is an iron chaperone that binds iron and delivers it to ferritin, a cytosolic iron storage protein.	Iron	74-78	poly(rC) binding protein 1	Homo sapiens	35-40
22055506-2	2011	Human poly (rC) binding protein 1 (PCBP1) is an iron chaperone that binds iron and delivers it to ferritin, a cytosolic iron storage protein.	Iron	74-78	poly(rC) binding protein 1	Homo sapiens	35-40
21852364-1	2011	The Menkes copper ATPase (Atp7a) and metallothionein (Mt1a) are induced in the duodenum of iron-deficient rats, and serum and hepatic copper levels increase.	Iron	91-95	metallothionein 1	Rattus norvegicus	54-58
21870996-1	2011	A number of antibodies have been developed that induce lethal iron deprivation (LID) by targeting the transferrin receptor 1 (TfR1/CD71) and either neutralizing transferrin (Tf) binding, blocking internalization of the receptor and/or inducing its degradation.	Iron	62-66	transferrin	Homo sapiens	126-128
21870996-0	2011	Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.	Iron	7-11	transferrin	Homo sapiens	73-84
21870996-1	2011	A number of antibodies have been developed that induce lethal iron deprivation (LID) by targeting the transferrin receptor 1 (TfR1/CD71) and either neutralizing transferrin (Tf) binding, blocking internalization of the receptor and/or inducing its degradation.	Iron	62-66	transferrin	Homo sapiens	102-113
22099154-0	2011	A QM/MM study of the complexes formed by aluminum and iron with serum transferrin at neutral and acidic pH.	Iron	54-58	transferrin	Homo sapiens	70-81
22099154-1	2011	Serum transferrin (sTf) transports iron in serum and internalizes in cells via receptor mediated endocytosis.	Iron	35-39	transferrin	Homo sapiens	6-17
21870996-3	2011	We now show that internalization of TfR1 bound to these antibodies can lead to its sequestration and degradation, as well as reduced Tf uptake, and the induction of a transcriptional response consistent with iron deprivation, which is mediated in part by downstream targets of p53.	Iron	208-212	transferrin	Homo sapiens	36-38
21783390-1	2011	Mutations of the TMPRSS6 gene are considered the major genetic factors for iron-refractory iron deficiency anemia (IRIDA).	Iron	75-79	transmembrane serine protease 6	Homo sapiens	17-24
21863061-2	2011	Furthermore, latest reports described BMPs, in particular BMP6, as important regulators of hepcidin expression in iron homeostasis.	Iron	114-118	bone morphogenetic protein 6	Homo sapiens	58-62
21841538-3	2011	We aimed to characterize HO-1-mediated effects on Fe2+ levels in liver and transferrin-bound iron (TFBI) in plasma following HTS, including laparotomy, bleeding, and inadequate and adequate reperfusion.	Iron	93-97	transferrin	Rattus norvegicus	75-86
21841538-10	2011	Transferrin-bound iron levels were affected by pharmacological modulation before shock.	Iron	18-22	transferrin	Rattus norvegicus	0-11
21973014-4	2011	The QM/MM-FE and QM/MM-PBSA calculations revealed that the PDE4-catalyzed hydrolysis of cAMP consists of two reaction stages: cAMP hydrolysis (stage 1) and bridging hydroxide ion regeneration (stage 2).	Iron	10-12	phosphodiesterase 4A	Homo sapiens	59-63
22020553-6	2011	A p38 MAPK inhibitor together with either an inhibitor of IkappaB kinase or a chelator of poorly liganded iron yielded synergistic inhibition of macrophage IL-1beta expression.	Iron	106-110	interleukin 1 beta	Homo sapiens	156-164
21768301-7	2011	In preclinical experiments using interventions such as transferrin, hepcidin agonists, and JAK2 inhibitors, we provide evidence of potential new treatment alternatives that elucidate mechanisms by which expanded or ineffective erythropoiesis may regulate iron supply, distribution, and utilization in diseases such as beta-thalassemia.	Iron	255-259	transferrin	Homo sapiens	55-66
21697218-7	2011	Computer modelling highlighted the important role of kininogen-1 as an anchor for mediated interactions with other identified proteins including ferritin light chain and ceruloplasmin, hepatocyte growth factor-like protein, as well as complement C3 and gelsolin, thus linking various biological processes including inflammation and angiogenesis, iron transport and storage, blood coagulation, innate immunity, cell adhesion and actin filament polymerization.	Iron	346-350	kininogen 1	Homo sapiens	53-64
22031445-6	2011	Here we report the preparation of fully active recombinant wild-type THI4p, the identification of an iron-dependent sulphide transfer reaction from a conserved cysteine residue of the protein to a reaction intermediate and the demonstration that THI4p is a suicide enzyme undergoing only a single turnover.	Iron	101-105	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	69-74
21873547-2	2011	Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption.	Iron	211-215	transmembrane serine protease 6	Homo sapiens	76-79
21873547-3	2011	TMPRSS6 inactivation causes iron-deficiency anemia refractory to iron administration both in humans and mice.	Iron	28-32	transmembrane serine protease 6	Homo sapiens	0-7
21873547-4	2011	Genome-wide association studies have shown that the SNP rs855791, which causes the MT2 V736A amino acid substitution, is associated with variations of serum iron, transferrin saturation, hemoglobin, and erythrocyte traits.	Iron	157-161	transmembrane serine protease 6	Homo sapiens	83-86
21745610-8	2011	Furthermore, the incorporation of Fe into mesoporous MBG glass scaffolds enhanced the mitochondrial activity and the expression of bone-related genes (ALP and OCN) in human bone marrow mesenchymal stem cells (BMSC) attached to the scaffolds.	Iron	34-36	bone gamma-carboxyglutamate protein	Homo sapiens	159-162
21945443-3	2011	The yeast transformants expressing AtCCX5 were created and their growth in the presence of various cations (K(+), Na(+), Ca(2+), Mg(2+), Fe(2+), Cu(2+), Co(2+), Cd(2+), Mn(2+), Ba(2+), Ni(2+), Zn(2+), and Li(+)) were analyzed.	Iron	137-139	cation exchanger 11	Arabidopsis thaliana	35-41
21870858-4	2011	Here we demonstrate that our prior phenomological data can be understood quantitatively in the loss of the methionine ligand of the heme iron, using the cytochrome c from  Hydrogenbacter thermophilum  as a model system.	Iron	137-141	cytochrome c, somatic	Homo sapiens	153-165
21856749-1	2011	Transferrin (Tf) endocytosis and recycling are essential for iron uptake and the regulation of cell proliferation.	Iron	61-65	transferrin	Homo sapiens	0-11
21870836-7	2011	Both Cu(+)-Abeta and heme (Fe(2+))-Abeta complexes reduce O(2) to H(2)O(2) quantitatively.	Iron	27-29	amyloid beta precursor protein	Homo sapiens	35-40
21742779-0	2011	Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation.	Iron	23-27	AKT serine/threonine kinase 1	Homo sapiens	138-141
21472415-1	2011	Lactoferrin (LF) is an iron-binding glycoprotein of the transferrin family, today known to have multifunctional physiological activities.	Iron	23-27	transferrin	Homo sapiens	56-67
22165676-4	2011	In the current study we evaluated the credibility of another indicator of body iron supply, serum transferrin receptor, in hemodialysis patients in two University-based Hospitals in North of Iran.	Iron	79-83	transferrin	Homo sapiens	98-109
22165676-13	2011	DISCUSSION: This study showed measurement of serum ferritin in the presence of chronic inflammation induced by renal failure cannot be a credible indicator of body iron supply, while under this certain condition serum transferrin receptor can more appropriately reflect the amount of body iron supply.	Iron	289-293	transferrin	Homo sapiens	218-229
21770702-4	2011	RESULTS: Molecular plutonium complexes introduced to cell growth media in the form of nitrilotriacetic acid (NTA), citrate, or transferrin complexes were taken up by PC12 cells, and mostly colocalized with iron within the cells.	Iron	206-210	transferrin	Rattus norvegicus	127-138
21528414-0	2011	Effect of biostimulation on the microbial community in PCB-contaminated sediments through periodic amendment of sediment with iron.	Iron	126-130	pyruvate carboxylase	Homo sapiens	55-58
21528414-9	2011	Biostimulation of indigenous PCB dechlorinators by the periodic amendment of contaminated sediments with low dosages of iron metal may therefore be an effective technology for remediation of PCB-contaminated sediments.	Iron	120-130	pyruvate carboxylase	Homo sapiens	29-32
21528414-9	2011	Biostimulation of indigenous PCB dechlorinators by the periodic amendment of contaminated sediments with low dosages of iron metal may therefore be an effective technology for remediation of PCB-contaminated sediments.	Iron	120-130	pyruvate carboxylase	Homo sapiens	191-194
21904748-3	2011	UV-VIS absorbance is employed here to monitor the iron content in human holo-transferrin (Tf) under various solvent conditions, changing polarity, pH, ionic strength, and the ionic and hydrophobic environment of the protein.	Iron	50-54	transferrin	Homo sapiens	77-88
21902732-0	2011	Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability.	Iron	61-65	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	34-39
21902732-0	2011	Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability.	Iron	61-65	electron carrier DRE2	Saccharomyces cerevisiae S288C	77-81
21902732-2	2011	Tah18 is a diflavin oxido-reductase with binding sites for flavin mononucleotide, flavin adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, which is able to transfer electrons to Dre2 Fe-S clusters.	Iron	203-207	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	0-5
21902732-2	2011	Tah18 is a diflavin oxido-reductase with binding sites for flavin mononucleotide, flavin adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, which is able to transfer electrons to Dre2 Fe-S clusters.	Iron	203-207	electron carrier DRE2	Saccharomyces cerevisiae S288C	198-202
21902732-7	2011	Conversely, enhancing artificially the interaction between mutated Dre2 and Tah18 restores cellular viability despite still reduced cytosolic Fe-S cluster biosynthesis.	Iron	142-146	electron carrier DRE2	Saccharomyces cerevisiae S288C	67-71
21902732-7	2011	Conversely, enhancing artificially the interaction between mutated Dre2 and Tah18 restores cellular viability despite still reduced cytosolic Fe-S cluster biosynthesis.	Iron	142-146	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	76-81
21785164-4	2011	Gene expression analysis revealed that the decreased intracellular levels of iron in preneoplastic foci might be attributed to increased iron export from the cells, driven by upregulation of ferroportin (Fpn1), the only known non-heme iron exporter.	Iron	77-81	solute carrier family 40 member 1	Rattus norvegicus	204-208
21996227-0	2011	Lack of non-transferrin-bound iron in heart transplant recipients.	Iron	30-34	transferrin	Homo sapiens	12-23
21996227-1	2011	BACKGROUND: Labile plasma iron (LPI) is a heterogeneous fraction thought to be composed of iron bound to serum albumin, citrate, and other undefined negatively charged ligands called non-transferrin-bound iron (NTBI).	Iron	26-30	transferrin	Homo sapiens	187-198
21802403-2	2011	Expressed mainly on the basolateral surface of duodenal enterocytes, hephaestin facilitates the export of iron from the intestinal epithelium into blood by oxidizing Fe(2+) into Fe(3+), the only form of iron bound by the plasma protein transferrin.	Iron	106-110	transferrin	Homo sapiens	236-247
21736832-2	2011	In the present study, we examined the gene expression of Hepcidin, a peptide hormone produced in the liver to regulate intestinal Fe absorption negatively, in Mg-deficient rats.	Iron	130-132	hepcidin antimicrobial peptide	Rattus norvegicus	57-65
21736832-4	2011	Previous studies revealed that Fe overload up-regulated Hepcidin expression through transcriptional activation by Fe-induced bone morphogenetic protein (Bmp) 6, a growth/differentiation factor belonging to the transforming growth factor-beta family, in the liver.	Iron	31-33	hepcidin antimicrobial peptide	Rattus norvegicus	56-64
21736832-4	2011	Previous studies revealed that Fe overload up-regulated Hepcidin expression through transcriptional activation by Fe-induced bone morphogenetic protein (Bmp) 6, a growth/differentiation factor belonging to the transforming growth factor-beta family, in the liver.	Iron	31-33	bone morphogenetic protein 6	Rattus norvegicus	153-159
21736832-4	2011	Previous studies revealed that Fe overload up-regulated Hepcidin expression through transcriptional activation by Fe-induced bone morphogenetic protein (Bmp) 6, a growth/differentiation factor belonging to the transforming growth factor-beta family, in the liver.	Iron	114-116	hepcidin antimicrobial peptide	Rattus norvegicus	56-64
21736832-4	2011	Previous studies revealed that Fe overload up-regulated Hepcidin expression through transcriptional activation by Fe-induced bone morphogenetic protein (Bmp) 6, a growth/differentiation factor belonging to the transforming growth factor-beta family, in the liver.	Iron	114-116	bone morphogenetic protein 6	Rattus norvegicus	153-159
21736832-7	2011	The present study indicates that accumulation of hepatic Fe by Mg deficiency is a stimulant inducing Bmp6 expression but not Hepcidin expression by blunting Bmp signalling possibly resulting from down-regulation of the receptor expression.	Iron	57-59	bone morphogenetic protein 6	Rattus norvegicus	101-105
21736832-8	2011	Unresponsive Hepcidin expression may have a role in Mg deficiency-induced changes related to increased liver Fe.	Iron	109-111	hepcidin antimicrobial peptide	Rattus norvegicus	13-21
21718726-2	2011	The pathogenesis is related to altered regulation of iron transport associated with steatosis, insulin resistance, and subclinical inflammation, often in the presence of predisposing genetic factors.	Iron	53-57	insulin	Homo sapiens	95-102
21718726-3	2011	Evidence is accumulating that excessive body iron plays a causal role in insulin resistance through still undefined mechanisms that probably involve a reduced ability to burn carbohydrates and altered function of adipose tissue.	Iron	45-49	insulin	Homo sapiens	73-80
21372265-7	2011	The group with iron overload had lower body mass index (17 versus 19; P = 0.01), total cholesterol (132 versus 165 mg/dL; P = 0.03) and hemoglobin (8.5 versus 10.6 g/dL; P = 0.003) but higher interleukin (IL)-6 levels (4.8 versus 3.6 ng/L; P = 0.04) and hypertension diagnosis (79 versus 48%; P &lt; 0.001) than those without iron overload.	Iron	15-19	interleukin 6	Homo sapiens	192-210
21996204-3	2011	Overt labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	20-24	transferrin	Homo sapiens	61-72
21996204-3	2011	Overt labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	79-83	transferrin	Homo sapiens	61-72
21996204-3	2011	Overt labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	79-83	transferrin	Homo sapiens	61-72
21903058-5	2011	First, iron homeostasis was deranged in anemic and nonanemic subjects and characterized by diminished circulating (transferrin saturation) and functional (mean cell hemoglobin concentration) iron status in the face of seemingly adequate stores (ferritin).	Iron	7-11	transferrin	Homo sapiens	115-126
21907923-2	2011	Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha.	Iron	62-66	charged multivesicular body protein 2B	Homo sapiens	57-61
21907923-2	2011	Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha.	Iron	108-112	iron responsive element binding protein 2	Homo sapiens	173-177
21907923-2	2011	Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha.	Iron	108-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	236-246
21823576-5	2011	Cleavage of the Roussin"s Red "ester" (mu-SPh)(2)[Fe(NO)(2)](2) with either NHC or imidazole results in the formation of (NHC-iPr)(PhS)Fe(NO)(2) (7) and (Imid-iPr)(PhS)Fe(NO)(2) (10) (Imid-iPr = 2-isopropylimidazole).	Iron	50-52	surfactant associated 3	Homo sapiens	42-45
21823576-5	2011	Cleavage of the Roussin"s Red "ester" (mu-SPh)(2)[Fe(NO)(2)](2) with either NHC or imidazole results in the formation of (NHC-iPr)(PhS)Fe(NO)(2) (7) and (Imid-iPr)(PhS)Fe(NO)(2) (10) (Imid-iPr = 2-isopropylimidazole).	Iron	135-137	surfactant associated 3	Homo sapiens	42-45
21708099-0	2011	Allosteric effects of sulfonate anions on the rates of iron release from serum transferrin.	Iron	55-59	transferrin	Homo sapiens	79-90
21359952-12	2011	These results strongly implicate glucocorticoid receptor and STAT5 in stress-induced up-regulation of IRP-1, which subsequently enhances transferrin receptor-1 expression and down-regulates ferritin, causing iron accumulation in the liver.	Iron	208-212	signal transducer and activator of transcription 5A	Rattus norvegicus	61-66
21194010-0	2011	Iron exposure modifies acetylcholinesterase activity in zebrafish (Danio rerio) tissues: distinct susceptibility of tissues to iron overload.	Iron	0-4	acetylcholinesterase	Danio rerio	23-43
21194010-3	2011	The aim of the present study was to evaluate the effects of iron on acetylcholinesterase (AChE) activity in brain and liver of zebrafish and to investigate the possible correlation with the iron content in these tissues.	Iron	60-64	acetylcholinesterase	Danio rerio	68-88
21194010-3	2011	The aim of the present study was to evaluate the effects of iron on acetylcholinesterase (AChE) activity in brain and liver of zebrafish and to investigate the possible correlation with the iron content in these tissues.	Iron	60-64	acetylcholinesterase	Danio rerio	90-94
21194010-5	2011	The in vitro studies showed that iron promoted a significant increase in AChE activity in brain (52%) and liver (53%) at the higher concentration (2.6 mM).	Iron	33-37	acetylcholinesterase	Danio rerio	73-77
21194010-9	2011	These results indicate that iron can promote significant alterations in AChE activity which probably is not directly related to the iron content in zebrafish tissues.	Iron	28-32	acetylcholinesterase	Danio rerio	72-76
21784947-4	2011	An important regulator of iron homeostasis is Fur (ferric uptake regulator), and here we present the first study of the Fur regulon in DC3000.	Iron	26-30	ferric iron uptake transcriptional regulator	Pseudomonas syringae pv. tomato str. DC3000	46-49
21784947-4	2011	An important regulator of iron homeostasis is Fur (ferric uptake regulator), and here we present the first study of the Fur regulon in DC3000.	Iron	26-30	ferric iron uptake transcriptional regulator	Pseudomonas syringae pv. tomato str. DC3000	51-74
21784947-4	2011	An important regulator of iron homeostasis is Fur (ferric uptake regulator), and here we present the first study of the Fur regulon in DC3000.	Iron	26-30	ferric iron uptake transcriptional regulator	Pseudomonas syringae pv. tomato str. DC3000	120-123
21784947-6	2011	Integration of these data with previous microarray and global transcriptome analyses allowed us to expand the putative DC3000 Fur regulon to include genes both repressed and activated in the presence of bioavailable iron.	Iron	216-220	ferric iron uptake transcriptional regulator	Pseudomonas syringae pv. tomato str. DC3000	126-129
21784947-7	2011	Using nonradioactive DNase I footprinting, we confirmed Fur binding in 41 regions, including upstream of 11 iron-repressed genes and the iron-activated genes encoding two bacterioferritins (PSPTO_0653 and PSPTO_4160), a ParA protein (PSPTO_0855), and a two-component system (TCS) (PSPTO_3382 to PSPTO_3380).	Iron	108-112	ferric iron uptake transcriptional regulator	Pseudomonas syringae pv. tomato str. DC3000	56-59
21784947-7	2011	Using nonradioactive DNase I footprinting, we confirmed Fur binding in 41 regions, including upstream of 11 iron-repressed genes and the iron-activated genes encoding two bacterioferritins (PSPTO_0653 and PSPTO_4160), a ParA protein (PSPTO_0855), and a two-component system (TCS) (PSPTO_3382 to PSPTO_3380).	Iron	137-141	ferric iron uptake transcriptional regulator	Pseudomonas syringae pv. tomato str. DC3000	56-59
21168460-2	2011	The aim of the study was to assess intra-hepatic iron in young patients with non-alcoholic fatty liver disease (NAFLD) and its association with insulin resistance and severity of liver damage.	Iron	49-53	insulin	Homo sapiens	144-151
21844295-6	2011	This could be attributed to the induction of the iron exporter ferroportin 1, which limited the availability of iron for intracellular Salmonella.	Iron	49-53	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	63-76
21844295-6	2011	This could be attributed to the induction of the iron exporter ferroportin 1, which limited the availability of iron for intracellular Salmonella.	Iron	112-116	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	63-76
21359952-0	2011	Glucocorticoid causes iron accumulation in liver by up-regulating expression of iron regulatory protein 1 gene through GR and STAT5.	Iron	22-26	signal transducer and activator of transcription 5A	Rattus norvegicus	126-131
21708099-4	2011	This paper describes the effect of sulfonate anions on the rates of iron removal from C-terminal monoferric transferrin by acetohydroxamic acid, deferiprone, nitrilotriacetic acid (NTA), and diethylenetriaminepentaacetic acid at 25 C in 0.1M N-(2-hydroxyethyl)piperazine-N"-(2-ethanesulfonic acid) (Hepes) buffer at pH 7.4.	Iron	68-72	transferrin	Homo sapiens	108-119
21708099-1	2011	Serum transferrin is the protein that transports ferric ion through the bloodstream and is thus a potential target for iron chelation therapy.	Iron	119-123	transferrin	Homo sapiens	6-17
21708099-2	2011	However, the release of iron from transferrin to low-molecular-weight chelating agents is usually quite slow.	Iron	24-28	transferrin	Homo sapiens	34-45
21720715-0	2011	Improved quantification for non-transferrin-bound iron measurement using high-performance liquid chromatography by reducing iron contamination.	Iron	50-54	transferrin	Homo sapiens	32-43
21785125-0	2011	Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.	Iron	53-57	transmembrane serine protease 6	Homo sapiens	23-30
21720715-1	2011	Non-transferrin-bound iron (NTBI) refers to all forms of iron in the plasma that bind to ligands other than transferrin, and is considered to be a marker of iron toxicity.	Iron	57-61	transferrin	Homo sapiens	4-15
21720715-0	2011	Improved quantification for non-transferrin-bound iron measurement using high-performance liquid chromatography by reducing iron contamination.	Iron	124-128	transferrin	Homo sapiens	32-43
21720715-1	2011	Non-transferrin-bound iron (NTBI) refers to all forms of iron in the plasma that bind to ligands other than transferrin, and is considered to be a marker of iron toxicity.	Iron	57-61	transferrin	Homo sapiens	4-15
21720715-1	2011	Non-transferrin-bound iron (NTBI) refers to all forms of iron in the plasma that bind to ligands other than transferrin, and is considered to be a marker of iron toxicity.	Iron	22-26	transferrin	Homo sapiens	4-15
21720715-1	2011	Non-transferrin-bound iron (NTBI) refers to all forms of iron in the plasma that bind to ligands other than transferrin, and is considered to be a marker of iron toxicity.	Iron	22-26	transferrin	Homo sapiens	108-119
21932715-2	2011	METHODS: A retrospective study was conducted in patients with iron overload (transferrin saturation &gt; or = 45%) who were tested for HH mutations from January 2003 to June 2007.	Iron	62-66	transferrin	Homo sapiens	77-88
22024494-7	2011	Superoxide dismutase (Sod1) and ceruloplasmin protein were found to be altered by both iron and CuD, whereas CCS and CCS/Sod1 ratio were found to only be altered only in CuD rats and, importantly, after only 1 week of treatment.	Iron	87-91	superoxide dismutase 1	Rattus norvegicus	22-26
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	137-141	lysozyme 2	Mus musculus	15-19
21705499-0	2011	Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses.	Iron	53-57	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-12
21705499-1	2011	Systemic iron requirements are met predominantly through the recycling of iron from senescent erythrocytes by macrophages, a process in which the iron exporter ferroportin (Fpn1) is considered to be essential.	Iron	9-13	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	173-177
20592101-9	2011	Positive correlations were found between T lymphocyte CD3 and CD4 percentages and Zn, Se, and Fe levels.	Iron	94-96	CD4 molecule	Homo sapiens	62-65
21724843-1	2011	The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism.	Iron	88-92	transmembrane serine protease 6	Homo sapiens	42-49
21724843-1	2011	The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism.	Iron	88-92	transmembrane serine protease 6	Homo sapiens	65-77
21724843-1	2011	The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism.	Iron	190-194	transmembrane serine protease 6	Homo sapiens	42-49
21724843-1	2011	The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism.	Iron	190-194	transmembrane serine protease 6	Homo sapiens	65-77
21724843-8	2011	Our results underscore for the first time the importance of TMPRSS6 trafficking at the plasma membrane in the regulation of hepcidin expression, an event that is essential for iron homeostasis.	Iron	176-180	transmembrane serine protease 6	Homo sapiens	60-67
21705499-1	2011	Systemic iron requirements are met predominantly through the recycling of iron from senescent erythrocytes by macrophages, a process in which the iron exporter ferroportin (Fpn1) is considered to be essential.	Iron	74-78	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	173-177
21705499-1	2011	Systemic iron requirements are met predominantly through the recycling of iron from senescent erythrocytes by macrophages, a process in which the iron exporter ferroportin (Fpn1) is considered to be essential.	Iron	74-78	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	173-177
21705499-2	2011	Yet the role of Fpn1 in macrophage iron recycling and whether it influences innate immune responses are poorly understood in vivo.	Iron	35-39	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	16-20
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	50-54	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	5-9
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	50-54	lysozyme 2	Mus musculus	10-14
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	50-54	lysozyme 2	Mus musculus	15-19
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	137-141	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	5-9
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	137-141	lysozyme 2	Mus musculus	10-14
21705499-9	2011	These studies demonstrate that Fpn1 plays important roles in macrophage iron release in vivo and in modulating innate immune responses.	Iron	72-76	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	31-35
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	137-141	lysozyme 2	Mus musculus	15-19
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	137-141	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	5-9
21705499-6	2011	When Fpn1(LysM/LysM) mice were challenged with an iron-deficient diet, they developed a more severe anemia and strikingly higher splenic iron levels than control mice, indicating significantly impaired iron mobilization from macrophages.	Iron	137-141	lysozyme 2	Mus musculus	10-14
21600194-0	2011	The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1.	Iron	29-33	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	75-94
21619874-2	2011	The presence of genetic transferrin variants might affect an individual"s iron status and can interfere with CDT analysis.	Iron	74-78	transferrin	Homo sapiens	24-35
21788477-0	2011	How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH.	Iron	82-86	transferrin	Homo sapiens	25-36
21788477-1	2011	Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface.	Iron	12-16	transferrin	Homo sapiens	72-83
21788477-1	2011	Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface.	Iron	50-54	transferrin	Homo sapiens	72-83
21672148-8	2011	In vivo rapamycin treatment induced higher degree of RICTOR and AKT Ser(473) expression directly correlating with long-term rapamycin exposure, FE(PO4) and HOMA index.	Iron	144-146	AKT serine/threonine kinase 1	Homo sapiens	64-67
21229380-3	2011	The pro-oxidant effects of IV iron are presumed to be due at least in part, by free or non-transferrin bound iron (NTBI).	Iron	30-34	transferrin	Homo sapiens	91-102
21801864-8	2011	RNA interference knockdown of ISCU expression in Swan 71, but not in BeWo, cells resulted in autophagosomal and siderosomal iron accumulation and a fourfold decrease of Matrigel invasion (P = 0.004).	Iron	124-128	iron-sulfur cluster assembly enzyme	Homo sapiens	30-34
21801864-12	2011	The findings herein suggest that ISCU down-regulation by miR-210 perturbing trophoblast iron metabolism is associated with defective placentation.	Iron	88-92	iron-sulfur cluster assembly enzyme	Homo sapiens	33-37
21229380-15	2011	In healthy controls, serum IL-6 was undetectable at baseline and after IV iron administration.	Iron	74-78	interleukin 6	Homo sapiens	27-31
21714710-4	2011	Total and transferrin-bound iron concentrations were determined for the 36-h period after infusion and corrected for pretreatment levels.	Iron	28-32	transferrin	Homo sapiens	10-21
21714710-9	2011	For transferrin-bound iron, the geometric mean ratios were 87% for corrected Cmax and 92% for corrected AUC[0-36].	Iron	22-26	transferrin	Homo sapiens	4-15
21652729-2	2011	We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo.	Iron	122-126	gastrin	Mus musculus	76-83
21615276-6	2011	Surprisingly, these studies have revealed that the homozygous deletion of CDKN2A/2B is a major hallmark of iron-induced carcinogenesis.	Iron	107-111	cyclin dependent kinase inhibitor 2A	Homo sapiens	74-83
22351255-0	2011	Removal of Pb(II) and Cd(II) ions from water by Fe and Ag nanoparticles prepared using electro-exploding wire technique.	Iron	48-50	submaxillary gland androgen regulated protein 3B	Homo sapiens	11-28
21646287-0	2011	Liver iron overload is associated with elevated SHBG concentration and moderate hypogonadotrophic hypogonadism in dysmetabolic men without genetic haemochromatosis.	Iron	6-10	sex hormone binding globulin	Homo sapiens	48-52
21646287-1	2011	AIMS: To assess the relation between moderate iron overload on sex hormone binding globulin (SHBG) levels and gonadotroph function in men with dysmetabolic iron overload syndrome and the effects of phlebotomy.	Iron	46-50	sex hormone binding globulin	Homo sapiens	63-91
21646287-1	2011	AIMS: To assess the relation between moderate iron overload on sex hormone binding globulin (SHBG) levels and gonadotroph function in men with dysmetabolic iron overload syndrome and the effects of phlebotomy.	Iron	46-50	sex hormone binding globulin	Homo sapiens	93-97
21646287-9	2011	Liver iron excess is associated with increased plasma SHBG and moderate hypogonadotrophic hypogonadism.	Iron	6-10	sex hormone binding globulin	Homo sapiens	54-58
21807323-4	2011	METHODS AND RESULTS: In the Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome (EPOCARES) study, which investigates the role of EPO in 54 iron-supplemented anemic patients with CHF and chronic kidney disease (CKD) (n = 35 treated with 50 IU/kg/wk Epopoetin beta, n = 19 control), RDW was not associated with EPO resistance.	Iron	151-155	erythropoietin	Homo sapiens	42-56
21678080-1	2011	Competitive binding of Fe(3+), Cr(3+), and Ni(2+) to transferrin (Tf) was investigated at various physiological iron to Tf concentration ratios.	Iron	112-116	transferrin	Homo sapiens	53-64
21678080-1	2011	Competitive binding of Fe(3+), Cr(3+), and Ni(2+) to transferrin (Tf) was investigated at various physiological iron to Tf concentration ratios.	Iron	112-116	transferrin	Homo sapiens	66-68
21678080-5	2011	Iron-overload concentrations impeded the ability of chromium (15.0 muM) or nickel (10.3 muM) to load completely into Tf.	Iron	0-4	latexin	Homo sapiens	67-70
21678080-5	2011	Iron-overload concentrations impeded the ability of chromium (15.0 muM) or nickel (10.3 muM) to load completely into Tf.	Iron	0-4	latexin	Homo sapiens	88-91
21678080-5	2011	Iron-overload concentrations impeded the ability of chromium (15.0 muM) or nickel (10.3 muM) to load completely into Tf.	Iron	0-4	transferrin	Homo sapiens	117-119
21678080-6	2011	Low Fe(3+) uptake by Tf under iron-deficient or chronic disease iron concentrations limited Ni(2+) loading into Tf.	Iron	30-34	transferrin	Homo sapiens	21-23
21807323-4	2011	METHODS AND RESULTS: In the Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome (EPOCARES) study, which investigates the role of EPO in 54 iron-supplemented anemic patients with CHF and chronic kidney disease (CKD) (n = 35 treated with 50 IU/kg/wk Epopoetin beta, n = 19 control), RDW was not associated with EPO resistance.	Iron	151-155	erythropoietin	Homo sapiens	93-96
21807323-4	2011	METHODS AND RESULTS: In the Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome (EPOCARES) study, which investigates the role of EPO in 54 iron-supplemented anemic patients with CHF and chronic kidney disease (CKD) (n = 35 treated with 50 IU/kg/wk Epopoetin beta, n = 19 control), RDW was not associated with EPO resistance.	Iron	151-155	erythropoietin	Homo sapiens	141-144
21457772-0	2011	Rescuing hepatocytes from iron-catalyzed oxidative stress using vitamins B1 and B6.	Iron	26-30	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	73-82
21653577-6	2011	However, dietary Zn and heme iron were positively associated with CRP [mean: 1.73, 1.75, 1.78, 1.88, and 1.96 mg/L across increasing quintiles of Zn and 1.72, 1.76, 1.83, 1.86, and 1.94 mg/L across increasing quintiles of heme iron (P-trend = 0.002 and 0.01, respectively).	Iron	29-33	C-reactive protein	Homo sapiens	66-69
21557313-0	2011	Iron-related MRI images in patients with pantothenate kinase-associated neurodegeneration (PKAN) treated with deferiprone: results of a phase II pilot trial.	Iron	0-4	pantothenate kinase 2	Homo sapiens	91-95
21877312-1	2011	Pantothenate kinase-associated neurodegeneration (PKAN) is a rare disorder associated with brain iron accumulation.	Iron	97-101	pantothenate kinase 2	Homo sapiens	50-54
22097806-4	2011	The results showed that endogenous cytoglobin exerted significant protective effects on hydrogen peroxide or iron-overload induced LX-2 cell damage, confirming that upregulation of cytoglobin was the protective response of activated hepatic stellate cells to oxidative stress.	Iron	109-113	cytoglobin	Homo sapiens	35-45
22097806-7	2011	Intracellular over-expression of cytoglobin protein could exert significant protective effect on LX-2 cells treated with hydrogen peroxide or iron-overload.	Iron	142-146	cytoglobin	Homo sapiens	33-43
21457772-7	2011	Together, these results indicate that added B1 and B6 vitamins protect against the multiple targets of iron-catalyzed oxidative damage in hepatocytes.	Iron	103-107	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	44-53
21849122-11	2011	There was a negative correlation between cellular labile iron pool and caspase-3 activity of K562 cells (r=-0.894, P&lt;0.05).	Iron	57-61	caspase 3	Homo sapiens	71-80
21777743-7	2011	RESULTS: HF patients displayed evidence of iron deficiency as measured by lower serum iron (p &lt; 0.05) and transferrin saturation (TFS) (p &lt; 0.05).	Iron	43-47	transferrin	Homo sapiens	109-120
21867640-2	2011	The iron overload model was set up by adding different concentration of ferric citrate (FAC) into the mononuclear cells from BM and culturing for different time, and the model was confirmed by detecting labile iron pool (LIP).	Iron	4-8	FA complementation group C	Homo sapiens	88-91
21741361-1	2011	Heme oxygenase-1 (HO-1), which catalyzes the degradation of free heme to biliverdin, carbon monoxide (CO), and free iron (Fe(2+)), is up-regulated by several cellular stress and cell injuries, including inflammation, ischemia and hypoxia.	Iron	116-120	heme oxygenase 1	Mus musculus	0-16
21741361-1	2011	Heme oxygenase-1 (HO-1), which catalyzes the degradation of free heme to biliverdin, carbon monoxide (CO), and free iron (Fe(2+)), is up-regulated by several cellular stress and cell injuries, including inflammation, ischemia and hypoxia.	Iron	116-120	heme oxygenase 1	Mus musculus	18-22
30505074-1	2011	We described the synthesis and characterization of a new class of bimetallic nanotubes based on Pd/Fe and demonstrated their efficacy in the dechlorination of PCB 77, a polychlorinated biphenyl.	Iron	99-101	pyruvate carboxylase	Homo sapiens	159-162
30505074-5	2011	The as-prepared Pd/Fe bimetallic nanotubes were used in dechlorination of 3,3",4,4"-tetrachlorobiphenyl (PCB 77).	Iron	19-21	pyruvate carboxylase	Homo sapiens	105-108
30505074-6	2011	In comparison with Pd/Fe nanoparticles, the Pd/Fe nanotubes demonstrated higher efficiency and faster dechlorination of the PCB.	Iron	22-24	pyruvate carboxylase	Homo sapiens	124-127
30505074-6	2011	In comparison with Pd/Fe nanoparticles, the Pd/Fe nanotubes demonstrated higher efficiency and faster dechlorination of the PCB.	Iron	47-49	pyruvate carboxylase	Homo sapiens	124-127
21245128-8	2011	CONCLUSION: Serum levels of both hepcidin and TNF-alpha are independently associated with arterial stiffness in MHD patients, suggesting that microinflammation and iron metabolism might affect the integrity of arterial walls.	Iron	164-168	tumor necrosis factor	Homo sapiens	46-55
21671584-10	2011	Together, these results suggest that Fxn facilitates sulfur transfer from Nfs1 to Isu2 and that these in vitro assays are sensitive and appropriate for deciphering functional defects and mechanistic details for human Fe-S cluster biosynthesis.	Iron	217-221	iron-sulfur cluster assembly enzyme	Homo sapiens	82-86
22093897-1	2011	OBJECTIVE: To discuss the regulating mechanism of iron regulatory protein-2 (IRP2) in the iron metabolism of lung cancer.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	77-81
22093897-11	2011	CONCLUSION: IRP2 may affect the expressions of TfR and Fn in lung adenocarcinoma A549 cells by changing the amount of protein and regulating the iron metabolism.	Iron	145-149	iron responsive element binding protein 2	Homo sapiens	12-16
20447705-5	2011	RESULTS: There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men.	Iron	101-105	transferrin	Homo sapiens	138-149
21622652-4	2011	In this study, we investigated whether BMP6 and iron also regulate TMPRSS6 expression.	Iron	48-52	transmembrane serine protease 6	Homo sapiens	67-74
21622652-8	2011	Our results indicate that BMP6 and iron not only induce hepcidin expression but also induce TMPRSS6, a negative regulator of hepcidin expression.	Iron	35-39	transmembrane serine protease 6	Homo sapiens	92-99
21622652-9	2011	Modulation of TMPRSS6 expression could serve as a negative feedback inhibitor to avoid excessive hepcidin increases by iron to help maintain tight homeostatic balance of systemic iron levels.	Iron	119-123	transmembrane serine protease 6	Homo sapiens	14-21
21622652-9	2011	Modulation of TMPRSS6 expression could serve as a negative feedback inhibitor to avoid excessive hepcidin increases by iron to help maintain tight homeostatic balance of systemic iron levels.	Iron	179-183	transmembrane serine protease 6	Homo sapiens	14-21
21628413-6	2011	We show that iron-deprived mice have a proinflammatory condition, exacerbated by LPS treatment leading to increased IL6 and TNFalpha mRNA in liver and spleen macrophages, and increased serum IL6 (482.29 +- 205.59 pg/mL) versus controls (69.01 +- 17.52 pg/mL; P &lt; .05).	Iron	13-17	interleukin 6	Mus musculus	116-119
21628413-6	2011	We show that iron-deprived mice have a proinflammatory condition, exacerbated by LPS treatment leading to increased IL6 and TNFalpha mRNA in liver and spleen macrophages, and increased serum IL6 (482.29 +- 205.59 pg/mL) versus controls (69.01 +- 17.52 pg/mL; P &lt; .05).	Iron	13-17	tumor necrosis factor	Mus musculus	124-132
21628413-6	2011	We show that iron-deprived mice have a proinflammatory condition, exacerbated by LPS treatment leading to increased IL6 and TNFalpha mRNA in liver and spleen macrophages, and increased serum IL6 (482.29 +- 205.59 pg/mL) versus controls (69.01 +- 17.52 pg/mL; P &lt; .05).	Iron	13-17	interleukin 6	Mus musculus	191-194
21622652-0	2011	Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.	Iron	34-38	transmembrane serine protease 6	Homo sapiens	14-21
21622652-2	2011	Patients with IRIDA have inappropriately elevated levels of the iron regulatory hormone hepcidin, suggesting that TMPRSS6 is involved in negatively regulating hepcidin expression.	Iron	64-68	transmembrane serine protease 6	Homo sapiens	114-121
20447705-5	2011	RESULTS: There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men.	Iron	150-154	transferrin	Homo sapiens	138-149
21604816-1	2011	The proposed method is based on the use of an isotopically enriched (57)Fe-transferrin complex to quantify natural transferrin (Tf) in human serum samples.	Iron	72-74	transferrin	Homo sapiens	75-86
21682303-7	2011	The catalytic action of nascent iron, an outcome of pin wear and disk wear, is shown to contribute to this detrimental effect.	Iron	32-36	dynein light chain LC8-type 1	Homo sapiens	52-55
21703414-4	2011	Given that bone morphogenetic protein 6 (Bmp6) is a major regulator of systemic iron, we examined the role of Bmp6 in retinal iron regulation and in AMD pathogenesis.	Iron	80-84	bone morphogenetic protein 6	Homo sapiens	11-39
21703414-4	2011	Given that bone morphogenetic protein 6 (Bmp6) is a major regulator of systemic iron, we examined the role of Bmp6 in retinal iron regulation and in AMD pathogenesis.	Iron	80-84	bone morphogenetic protein 6	Homo sapiens	41-45
21703414-4	2011	Given that bone morphogenetic protein 6 (Bmp6) is a major regulator of systemic iron, we examined the role of Bmp6 in retinal iron regulation and in AMD pathogenesis.	Iron	126-130	bone morphogenetic protein 6	Homo sapiens	110-114
21703414-6	2011	In cultured RPE cells, Bmp6 was down-regulated by oxidative stress and up-regulated by iron.	Iron	87-91	bone morphogenetic protein 6	Homo sapiens	23-27
21703414-10	2011	Because oxidative stress is associated with AMD pathogenesis and down-regulates Bmp6 in cultured RPE cells, the diminished Bmp6 levels observed in RPE cells in early AMD may contribute to iron build-up in AMD.	Iron	188-192	bone morphogenetic protein 6	Homo sapiens	123-127
21558272-1	2011	Iron regulatory protein 2 (IRP2) controls the synthesis of many proteins involved in iron metabolism, and the level of IRP2 itself is regulated by varying the rate of its degradation.	Iron	85-89	iron responsive element binding protein 2	Homo sapiens	0-25
21558272-1	2011	Iron regulatory protein 2 (IRP2) controls the synthesis of many proteins involved in iron metabolism, and the level of IRP2 itself is regulated by varying the rate of its degradation.	Iron	85-89	iron responsive element binding protein 2	Homo sapiens	27-31
21558272-1	2011	Iron regulatory protein 2 (IRP2) controls the synthesis of many proteins involved in iron metabolism, and the level of IRP2 itself is regulated by varying the rate of its degradation.	Iron	85-89	iron responsive element binding protein 2	Homo sapiens	119-123
21558272-3	2011	Most studies on the degradation of IRP2 have employed cells overexpressing IRP2 and also rendered iron deficient to further increase IRP2 levels.	Iron	98-102	iron responsive element binding protein 2	Homo sapiens	35-39
21558272-8	2011	We conclude that under physiological, iron-sufficient conditions, the steady-state level of IRP2 in HEK293A cells is regulated by the nonproteasomal pathway.	Iron	38-42	iron responsive element binding protein 2	Homo sapiens	92-96
21769749-4	2011	In the majority of the patients reported, a mutation of the gene that encodes the pantothenate kinase (PANK2) located in the 20p13-p12.3 chromosome that causes iron storage in the basal ganglia of the brain has been found.	Iron	160-164	pantothenate kinase 2	Homo sapiens	103-108
21436314-1	2011	The divalent metal transporter (DMT1, Slc11a2) is an important molecule for intestinal iron absorption.	Iron	87-91	solute carrier family 11 member 2	Rattus norvegicus	32-36
21436314-1	2011	The divalent metal transporter (DMT1, Slc11a2) is an important molecule for intestinal iron absorption.	Iron	87-91	solute carrier family 11 member 2	Rattus norvegicus	38-45
21604816-1	2011	The proposed method is based on the use of an isotopically enriched (57)Fe-transferrin complex to quantify natural transferrin (Tf) in human serum samples.	Iron	72-74	transferrin	Homo sapiens	115-126
21436314-2	2011	In the Belgrade (b/b) rat, the DMT1 G185R mutation markedly decreases intestinal iron absorption.	Iron	81-85	solute carrier family 11 member 2	Rattus norvegicus	31-35
21685238-4	2011	Iron overload was observed in all iron-treated rats, as evidenced by significant increases in serum iron indices, expression of liver hepcidin gene and total tissue iron content compared with control rats.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	134-142
21436314-7	2011	The results showed that expression of hepatic hepcidin was significantly decreased and intestinal Hif2alpha was significantly increased in b/b and iron-fed b/b than +/+ rats.	Iron	147-151	hepcidin antimicrobial peptide	Rattus norvegicus	46-54
21436314-10	2011	Thus in b/b rats depressed liver hepcidin production and activated intestinal Hif2alpha starting at the C-pole resulted in increasing expression of iron transport genes, including DMT1 G185R, in an attempt to compensate for the anemia in Belgrade rats.	Iron	148-152	solute carrier family 11 member 2	Rattus norvegicus	180-184
21249458-1	2011	INTRODUCTION: The nano-scale zero-valent iron (NZVI) was used for the removal of arsenite (As(III)) and arsenate (As(V)) in aqueous solution.	Iron	41-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	113-119
20812788-4	2011	Several predominant iron-sulfur biogenesis systems have been identified, including nitrogen fixation (NIF), sulfur utilization factor (SUF), iron-sulfur cluster (ISC), and cytosolic iron-sulfur protein assembly (CIA), and many protein components have been identified and characterized.	Iron	20-24	nuclear receptor coactivator 5	Homo sapiens	212-215
21299470-3	2011	In Saccharomyces cerevisiae, the multidomain Grx3 and Grx4 play an essential role in intracellular iron trafficking.	Iron	99-103	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	54-58
21299470-8	2011	Grx4 functions as iron sensor for the iron-sensing transcription factor Aft1 in S. cerevisiae.	Iron	18-22	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	0-4
21299470-8	2011	Grx4 functions as iron sensor for the iron-sensing transcription factor Aft1 in S. cerevisiae.	Iron	38-42	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	0-4
21685238-4	2011	Iron overload was observed in all iron-treated rats, as evidenced by significant increases in serum iron indices, expression of liver hepcidin gene and total tissue iron content compared with control rats.	Iron	34-38	hepcidin antimicrobial peptide	Rattus norvegicus	134-142
21491498-2	2011	Mutations in the FA2H gene cause leukodystrophy, spastic paraplegia, and neurodegeneration with brain iron accumulation.	Iron	102-106	fatty acid 2-hydroxylase	Mus musculus	17-21
21490148-5	2011	Gex1 expression was induced under conditions of iron depletion and was principally dependent on the iron-responsive transcription factor Aft2.	Iron	48-52	glutathione exchanger	Saccharomyces cerevisiae S288C	0-4
21511908-9	2011	Taking all of these findings together, a novel function and signalling pathway of Fe-deficiency-induced root branching is presented where NOS-generated rather than NR-generated NO acts downstream of auxin in regulating this Fe-deficiency-induced response, which enhances the plant tolerance to Fe-deficiency.	Iron	82-84	nitrate reductase [NADH]	Solanum lycopersicum	164-166
22922860-2	2011	Iron supplements are commonly prescribed for these patients with or without erythropoietin therapy by means of oral and intravenous iron.	Iron	0-4	erythropoietin	Homo sapiens	76-90
22922860-4	2011	The objective of the study is to analyze the efficacy of oral and intravenous iron in chronic kidney disease patients on erythropoietin therapy, an erythropoiesis stimulating agents for increment of haemoglobin.	Iron	78-82	erythropoietin	Homo sapiens	121-135
21742986-0	2011	The FRD3 citrate effluxer promotes iron nutrition between symplastically disconnected tissues throughout Arabidopsis development.	Iron	35-39	MATE efflux family protein	Arabidopsis thaliana	4-8
21742986-1	2011	We present data supporting a general role for FERRIC REDICTASE DEFECTIVE3 (FRD3), an efflux transporter of the efficient iron chelator citrate, in maintaining iron homeostasis throughout plant development.	Iron	121-125	MATE efflux family protein	Arabidopsis thaliana	46-73
21742986-1	2011	We present data supporting a general role for FERRIC REDICTASE DEFECTIVE3 (FRD3), an efflux transporter of the efficient iron chelator citrate, in maintaining iron homeostasis throughout plant development.	Iron	121-125	MATE efflux family protein	Arabidopsis thaliana	75-79
21742986-3	2011	Consistently, frd3 loss-of-function mutants are defective in early germination and are almost completely sterile, both defects being rescued by iron and/or citrate supply.	Iron	144-148	MATE efflux family protein	Arabidopsis thaliana	14-18
21742986-6	2011	This points to a role for FRD3 and citrate in proper iron nutrition of embryo and pollen.	Iron	53-57	MATE efflux family protein	Arabidopsis thaliana	26-30
21742986-7	2011	Based on the findings that iron acquisition in embryo, leaf, and pollen depends on FRD3, we propose that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.	Iron	27-31	MATE efflux family protein	Arabidopsis thaliana	83-87
21742986-7	2011	Based on the findings that iron acquisition in embryo, leaf, and pollen depends on FRD3, we propose that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.	Iron	27-31	MATE efflux family protein	Arabidopsis thaliana	105-109
21742986-7	2011	Based on the findings that iron acquisition in embryo, leaf, and pollen depends on FRD3, we propose that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.	Iron	210-214	MATE efflux family protein	Arabidopsis thaliana	83-87
21742986-7	2011	Based on the findings that iron acquisition in embryo, leaf, and pollen depends on FRD3, we propose that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.	Iron	210-214	MATE efflux family protein	Arabidopsis thaliana	105-109
21540277-6	2011	Iron concentrations in the liver, kidney, and spleen were increased, derived from internally released iron from hemolyzed red blood cells, increased duodenal iron absorption, insufficient erythropoiesis, and hepatic ferritin overproduced by cadmium-induced interleukin-6.	Iron	0-4	interleukin 6	Rattus norvegicus	257-270
21636783-6	2011	In the complex the [2Fe-2S] cluster of Adx is positioned 17.4 A away from the heme iron of CYP11A1.	Iron	83-87	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	91-98
21315474-3	2011	From microarray analysis of Arabidopsis roots, it is known that three different cytochrome P450 genes, CYP82C4, CYP82C3 and CYP71B5 are up-regulated under Fe deficiency through a FIT-dependent pathway.	Iron	155-157	cytochrome p450 71b5	Arabidopsis thaliana	124-131
21570398-0	2011	Reduced expression of ferroportin-1 mediates hyporesponsiveness of suckling rats to stimuli that reduce iron absorption.	Iron	104-108	solute carrier family 40 member 1	Rattus norvegicus	22-35
21570398-2	2011	In adults, iron absorption is controlled by systemic signals that alter expression of the iron-regulatory hormone hepcidin.	Iron	11-15	hepcidin antimicrobial peptide	Rattus norvegicus	114-122
21570398-10	2011	The hyporesponsiveness of iron absorption to increased levels of hepcidin during suckling correlated with reduced or absent duodenal expression of ferroportin 1 (Fpn1), normally a hepcidin target.	Iron	26-30	hepcidin antimicrobial peptide	Rattus norvegicus	65-73
21570398-10	2011	The hyporesponsiveness of iron absorption to increased levels of hepcidin during suckling correlated with reduced or absent duodenal expression of ferroportin 1 (Fpn1), normally a hepcidin target.	Iron	26-30	hepcidin antimicrobial peptide	Rattus norvegicus	180-188
21570398-12	2011	Predominance of the Fpn1A splice variant, which is under iron-dependent translational control, accounts for the low level of Fpn1 in the iron-deficient intestine of suckling rats.	Iron	57-61	solute carrier family 40 member 1	Rattus norvegicus	20-24
21570398-12	2011	Predominance of the Fpn1A splice variant, which is under iron-dependent translational control, accounts for the low level of Fpn1 in the iron-deficient intestine of suckling rats.	Iron	137-141	solute carrier family 40 member 1	Rattus norvegicus	20-24
21570398-13	2011	CONCLUSIONS: Iron absorption during suckling is largely refractory to changes in expression of the systemic iron regulator hepcidin, and this in turn reflects limited expression of Fpn1 protein in the small intestine.	Iron	108-112	hepcidin antimicrobial peptide	Rattus norvegicus	123-131
21711425-13	2011	CONCLUSION:   These findings indicated that the iron chelation exerted a hepatoprotective effect by scavenging ROS upstream of caspase-3 and that iron chelation with deferasirox is a potential treatment for patients with fulminant hepatitis.	Iron	48-52	caspase 3	Homo sapiens	127-136
21527524-8	2011	Additional significant, though less strong, associations were observed for C-reactive protein and total iron binding capacity in men and for total iron binding capacity, alanine aminotransferase, and glomerular filtration rate in women.	Iron	104-108	C-reactive protein	Homo sapiens	75-93
21700214-1	2011	Human anamorsin was implicated in cytosolic iron-sulfur (Fe/S) protein biogenesis.	Iron	57-59	cytokine induced apoptosis inhibitor 1	Homo sapiens	6-15
21464130-11	2011	Finally, we show that reducing the function of other genes involved in Fe-S cluster production produces similar phenotypic consequences to abtm-1 loss of function.	Iron	71-75	ABC Transporter, Mitochondrial	Caenorhabditis elegans	139-145
21487007-1	2011	Gram-negative porcine pathogens from the Pasteurellaceae family possess a surface receptor complex capable of acquiring iron from porcine transferrin (pTf).	Iron	120-124	transferrin	Homo sapiens	138-149
21490148-5	2011	Gex1 expression was induced under conditions of iron depletion and was principally dependent on the iron-responsive transcription factor Aft2.	Iron	100-104	glutathione exchanger	Saccharomyces cerevisiae S288C	0-4
21490148-5	2011	Gex1 expression was induced under conditions of iron depletion and was principally dependent on the iron-responsive transcription factor Aft2.	Iron	100-104	Aft2p	Saccharomyces cerevisiae S288C	137-141
21422192-10	2011	Modeling studies with CYP2D6 revealed potential roles of various active site residues in the oxidation of SCH 66712 and inactivation of CYP2D6 and showed that the phenyl group of SCH 66712 is positioned at 2.2 A from the heme iron.	Iron	226-230	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	22-28
21368293-5	2011	HIF-1 and HIF-2 regulate many genes that are involved in erythropoiesis and iron metabolism, which are essential for tissue oxygen delivery.	Iron	76-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
21188548-3	2011	ST13, isolated from human stool, was evaluated for siderophoregenic and probiotic qualities prior to its possible application for iron nutrition in humans and animals.	Iron	130-134	ST13 Hsp70 interacting protein	Homo sapiens	0-4
21570952-6	2011	In addition, the Fe-S cluster content of glutamine phosphoribosyl pyrophosphate amidotransferase and mitochondrial aconitase was dramatically decreased.	Iron	17-19	aconitase 2	Homo sapiens	101-124
21430118-1	2011	BACKGROUND: Total body iron calculated from serum ferritin and soluble transferrin receptor concentrations allows for the evaluation of the full range of iron status.	Iron	23-27	transferrin	Homo sapiens	71-82
21430118-1	2011	BACKGROUND: Total body iron calculated from serum ferritin and soluble transferrin receptor concentrations allows for the evaluation of the full range of iron status.	Iron	154-158	transferrin	Homo sapiens	71-82
21070572-10	2011	CONCLUSION:   Anaemia depends on serum IL-6, which is a strong inductor of CRP and regulator of the iron-transport.	Iron	100-104	interleukin 6	Homo sapiens	39-43
21422192-10	2011	Modeling studies with CYP2D6 revealed potential roles of various active site residues in the oxidation of SCH 66712 and inactivation of CYP2D6 and showed that the phenyl group of SCH 66712 is positioned at 2.2 A from the heme iron.	Iron	226-230	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	136-142
21357408-0	2011	Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium.	Iron	15-19	succinate receptor 1	Mus musculus	63-68
21352821-3	2011	HepG2 cells overexpressing CYP2E1 were subjected to arachidonic acid, iron and 100mM ethanol with or without the antioxidant agent.	Iron	70-74	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	27-33
21396368-2	2011	In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from SLC40A1 mutations that confer resistance of ferroportin to hepcidin-mediated inactivation.	Iron	153-157	transferrin	Homo sapiens	89-100
21396368-6	2011	A patient with hepatocellular iron storage, hyperferritinemia, and increased transferrin saturation was heterozygous for p.H507R.	Iron	30-34	transferrin	Homo sapiens	77-88
21402762-0	2011	Staphylococcus aureus transporters Hts, Sir, and Sst capture iron liberated from human transferrin by Staphyloferrin A, Staphyloferrin B, and catecholamine stress hormones, respectively, and contribute to virulence.	Iron	61-65	transferrin	Homo sapiens	87-98
21402762-2	2011	In the bloodstream, the iron-binding glycoprotein transferrin circulates to provide iron to cells throughout the body, but its iron-binding properties make it an important component of innate immunity.	Iron	24-28	transferrin	Homo sapiens	50-61
21402762-2	2011	In the bloodstream, the iron-binding glycoprotein transferrin circulates to provide iron to cells throughout the body, but its iron-binding properties make it an important component of innate immunity.	Iron	84-88	transferrin	Homo sapiens	50-61
21402762-2	2011	In the bloodstream, the iron-binding glycoprotein transferrin circulates to provide iron to cells throughout the body, but its iron-binding properties make it an important component of innate immunity.	Iron	84-88	transferrin	Homo sapiens	50-61
21402762-3	2011	It is well established that siderophores, with their high affinity for iron, in many instances can remove iron from transferrin as a means to promote proliferation of bacterial pathogens.	Iron	71-75	transferrin	Homo sapiens	116-127
21402762-3	2011	It is well established that siderophores, with their high affinity for iron, in many instances can remove iron from transferrin as a means to promote proliferation of bacterial pathogens.	Iron	106-110	transferrin	Homo sapiens	116-127
21402762-4	2011	It is also established that catecholamine hormones can interfere with the iron-binding properties of transferrin, thus allowing infectious bacteria access to this iron pool.	Iron	74-78	transferrin	Homo sapiens	101-112
21402762-4	2011	It is also established that catecholamine hormones can interfere with the iron-binding properties of transferrin, thus allowing infectious bacteria access to this iron pool.	Iron	163-167	transferrin	Homo sapiens	101-112
21402762-5	2011	The present study demonstrates that S. aureus can use either of two carboxylate-type siderophores, staphyloferrin A and staphyloferrin B, via the transporters Hts and Sir, respectively, to access the transferrin iron pool.	Iron	212-216	transferrin	Homo sapiens	200-211
21626456-7	2011	The increment of serum iron and % transferrin saturation at 120 min after SFC administration was useful in distinguishing iron absorption between healthy volunteers, patients with iron-deficiency anemia, and patients with anemia secondary to chronic disorders, which are respectively characterized by normal, enhanced, and reduced iron absorption.	Iron	122-126	transferrin	Homo sapiens	34-45
21626456-7	2011	The increment of serum iron and % transferrin saturation at 120 min after SFC administration was useful in distinguishing iron absorption between healthy volunteers, patients with iron-deficiency anemia, and patients with anemia secondary to chronic disorders, which are respectively characterized by normal, enhanced, and reduced iron absorption.	Iron	122-126	transferrin	Homo sapiens	34-45
21308772-7	2011	Interestingly, iron, particularly in its inorganic form, and to a lesser extent ferritin and transferrin all suppressed alkaline phosphatase (ALP) activities in osteoblasts.	Iron	15-19	alkaline phosphatase, placental	Homo sapiens	120-140
21308772-7	2011	Interestingly, iron, particularly in its inorganic form, and to a lesser extent ferritin and transferrin all suppressed alkaline phosphatase (ALP) activities in osteoblasts.	Iron	15-19	alkaline phosphatase, placental	Homo sapiens	142-145
21308772-8	2011	Moreover, iron downregulated mRNA levels of several other osteoblastogenic markers such as Runx2, osterix, osteopontin, and osteocalcin.	Iron	10-14	RUNX family transcription factor 2	Homo sapiens	91-96
21357408-4	2011	Therefore, we examined the expression and iron-dependent regulation of GPR91 in the RPE.	Iron	42-46	succinate receptor 1	Mus musculus	71-76
21308772-8	2011	Moreover, iron downregulated mRNA levels of several other osteoblastogenic markers such as Runx2, osterix, osteopontin, and osteocalcin.	Iron	10-14	bone gamma-carboxyglutamate protein	Homo sapiens	124-135
21308772-10	2011	Although iron inhibited preosteoblast cell differentiation, it did enhance preosteoblast cell proliferation, as evidenced by increased cell growth and expression of cell cycle regulator genes such as CDK4, CDK6, cyclin D1, and cyclin D3 and G(2) /M phase cell population.	Iron	9-13	cyclin D3	Homo sapiens	227-236
21357408-12	2011	Iron accumulation in cells induced by CMV infection, expression of CMV-US2, or treatment with FAC increased GPR91 expression.	Iron	0-4	succinate receptor 1	Mus musculus	108-113
21357408-16	2011	Excessive iron in the retina and RPE enhances GPR91 expression; however, VEGF expression does not always parallel GPR91 expression.	Iron	10-14	succinate receptor 1	Mus musculus	46-51
21531760-0	2011	Fe binding properties of two soybean (Glycine max L.) LEA4 proteins associated with antioxidant activity.	Iron	0-2	seed maturation protein	Glycine max	54-58
21942197-7	2011	Chemical processes that may influence AIRP performance are also discussed herein, including iron and arsenic oxidation, arsenic co-precipitation with iron, multiple iron additions, interference by organics, and iron crystallization.	Iron	92-96	5'-nucleotidase, cytosolic IB	Homo sapiens	38-42
21942197-7	2011	Chemical processes that may influence AIRP performance are also discussed herein, including iron and arsenic oxidation, arsenic co-precipitation with iron, multiple iron additions, interference by organics, and iron crystallization.	Iron	150-154	5'-nucleotidase, cytosolic IB	Homo sapiens	38-42
21942197-7	2011	Chemical processes that may influence AIRP performance are also discussed herein, including iron and arsenic oxidation, arsenic co-precipitation with iron, multiple iron additions, interference by organics, and iron crystallization.	Iron	150-154	5'-nucleotidase, cytosolic IB	Homo sapiens	38-42
21942197-7	2011	Chemical processes that may influence AIRP performance are also discussed herein, including iron and arsenic oxidation, arsenic co-precipitation with iron, multiple iron additions, interference by organics, and iron crystallization.	Iron	150-154	5'-nucleotidase, cytosolic IB	Homo sapiens	38-42
21430023-14	2011	The mechanism by which iron load induces insulin resistance is possibly independent of the pathways involved in insulin resistance induced by fatty liver disease.	Iron	23-27	insulin	Homo sapiens	41-48
21384276-2	2011	The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF).	Iron	138-142	transferrin	Homo sapiens	84-95
21384276-2	2011	The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF).	Iron	138-142	transferrin	Homo sapiens	106-108
21376789-0	2011	The impact of highly hydrophobic material on the structure of transferrin and its ability to bind iron.	Iron	98-102	transferrin	Homo sapiens	62-73
21734909-4	2011	Studies with isogenic mutants have improved our understanding of the requirements for gonococcal LOS structures, pili, opacity proteins, IgA1 protease, and the ability of infecting organisms to obtain iron from human transferrin and lactoferrin during uncomplicated urethritis.	Iron	201-205	transferrin	Homo sapiens	217-228
21376789-7	2011	Analytical studies of these novel complexes may shed a light on the mechanism by which transferrin could lose its ability to bind and thus to transport and store iron.	Iron	162-166	transferrin	Homo sapiens	87-98
21310927-1	2011	Mitoferrin1 is 1 of 2 homologous mitochondrial iron transporters and is required for mitochondrial iron delivery in developing erythroid cells.	Iron	47-51	solute carrier family 25, member 37	Mus musculus	0-11
21747812-5	2011	Iron transport systems facilitating the use of transferrin, lactoferrin, and hemoglobin have two components: one TonB-dependent transporter and one lipoprotein.	Iron	0-4	transferrin	Homo sapiens	47-58
21747812-8	2011	The best characterized iron transport system expressed by N. gonorrhoeae enables the use of human transferrin as a sole iron source.	Iron	23-27	transferrin	Homo sapiens	98-109
21747812-8	2011	The best characterized iron transport system expressed by N. gonorrhoeae enables the use of human transferrin as a sole iron source.	Iron	120-124	transferrin	Homo sapiens	98-109
21747812-9	2011	This review summarizes the molecular mechanisms involved in gonococcal iron acquisition from human transferrin and also reviews what is currently known about the other TonB-dependent transport systems.	Iron	71-75	transferrin	Homo sapiens	99-110
21256833-0	2011	A high-performance liquid immunoaffinity chromatography method for determining transferrin-bound iron in serum.	Iron	97-101	transferrin	Homo sapiens	79-90
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Iron	106-108	cystathionine beta-synthase	Homo sapiens	26-29
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Iron	106-108	cystathionine beta-synthase	Homo sapiens	109-113
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Iron	106-108	cystathionine beta-synthase	Homo sapiens	175-179
21256833-1	2011	BACKGROUND: The analyzed values in the ICSH reference method for serum iron analysis are affected by non-transferrin(Tf)-bound iron such as ferritin.	Iron	71-75	transferrin	Homo sapiens	105-116
21449619-3	2011	In combination with different chiral ligands, the iron- and titanium-catalyzed asymmetric oxidations of tri- and tetrasubstituted 2-thioimidazoles afford the corresponding sulfoxides with enantiomeric excesses up to 99% as novel p38alpha mitogen-activated protein kinase (p38alpha MAPK) inhibitors.	Iron	50-54	mitogen-activated protein kinase 14	Homo sapiens	229-237
21256833-1	2011	BACKGROUND: The analyzed values in the ICSH reference method for serum iron analysis are affected by non-transferrin(Tf)-bound iron such as ferritin.	Iron	127-131	transferrin	Homo sapiens	105-116
21449619-3	2011	In combination with different chiral ligands, the iron- and titanium-catalyzed asymmetric oxidations of tri- and tetrasubstituted 2-thioimidazoles afford the corresponding sulfoxides with enantiomeric excesses up to 99% as novel p38alpha mitogen-activated protein kinase (p38alpha MAPK) inhibitors.	Iron	50-54	mitogen-activated protein kinase 14	Homo sapiens	272-280
21256833-3	2011	We developed a specific determination method for serum transferrin-bound iron (serum t Fe) by high-performance liquid immunoaffinity chromatography (HPLAC), and compared it with the ICSH method and a fully automated (FA) method.	Iron	73-77	transferrin	Homo sapiens	55-66
21256833-3	2011	We developed a specific determination method for serum transferrin-bound iron (serum t Fe) by high-performance liquid immunoaffinity chromatography (HPLAC), and compared it with the ICSH method and a fully automated (FA) method.	Iron	87-89	transferrin	Homo sapiens	55-66
21315066-1	2011	BACKGROUND: Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage.	Iron	107-111	haptoglobin	Homo sapiens	12-23
21316675-0	2011	Association of haptoglobin genotype and common cardiovascular risk factors with the amount of iron in atherosclerotic carotid plaques.	Iron	94-98	haptoglobin	Homo sapiens	15-26
21513700-6	2011	Both PICOT and the yeast homolog of AM are known to be iron-sulfur proteins.	Iron	55-59	glutaredoxin 3	Mus musculus	5-10
21554740-10	2011	The most specific and linear response was observed for pyoverdin immobilized in sol-gel C. In contrast, a solution of pyoverdin (3.0 muM) exposed to iron (II or III) for 10 minutes showed an increase in fluorescence (101 - 114%) at low ferrous concentrations (0.45 - 2.18 muM) while exposure to all ferric ion concentrations (0.45 - 3.03 muM) caused quenching.	Iron	149-153	latexin	Homo sapiens	272-275
21554740-10	2011	The most specific and linear response was observed for pyoverdin immobilized in sol-gel C. In contrast, a solution of pyoverdin (3.0 muM) exposed to iron (II or III) for 10 minutes showed an increase in fluorescence (101 - 114%) at low ferrous concentrations (0.45 - 2.18 muM) while exposure to all ferric ion concentrations (0.45 - 3.03 muM) caused quenching.	Iron	149-153	latexin	Homo sapiens	272-275
21393479-2	2011	In this highly prevalent form of anemia, inflammatory cytokines, including IL-6, stimulate hepatic expression of hepcidin, which negatively regulates iron bioavailability by inactivating ferroportin.	Iron	150-154	interleukin 6	Homo sapiens	75-79
21393479-7	2011	In mice, treatment with IL-6 or turpentine increased hepcidin expression and reduced serum iron, effects that were inhibited by LDN-193189 or ALK3-Fc.	Iron	91-95	interleukin 6	Mus musculus	24-28
21393479-9	2011	Our studies support the concept that BMP and IL-6 act together to regulate iron homeostasis and suggest that inhibition of BMP signaling may be an effective strategy for the treatment of anemia of inflammation.	Iron	75-79	interleukin 6	Homo sapiens	45-49
21411619-8	2011	CRP but not iron intake was a strong negative predictor of iron status, independently of BMI (P &lt; 0.05).	Iron	59-63	C-reactive protein	Homo sapiens	0-3
21654899-4	2011	In several kinds of protein complexes exemplified by methemoglobin, transferrin or ferritin, various forms of trivalent iron have been found.	Iron	120-124	transferrin	Homo sapiens	68-79
21654899-7	2011	A good correlation has been found between the EPR results, the total iron ion complexes concentration and transferrin saturation.	Iron	69-73	transferrin	Homo sapiens	106-117
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	113-117
21320535-5	2011	The demonstration of an interaction between gastrin and transferrin by biochemical techniques led to the proposal that gastrins catalyze the loading of transferrin with iron.	Iron	169-173	transferrin	Homo sapiens	56-67
21320535-5	2011	The demonstration of an interaction between gastrin and transferrin by biochemical techniques led to the proposal that gastrins catalyze the loading of transferrin with iron.	Iron	169-173	transferrin	Homo sapiens	152-163
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	79-83	iron responsive element binding protein 2	Homo sapiens	113-117
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	79-83	iron responsive element binding protein 2	Homo sapiens	113-117
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	79-83	iron responsive element binding protein 2	Homo sapiens	113-117
21605006-9	2011	Loading of Fe on LA but not chelation slightly decreased neutrophilic influx (LA + DEF &gt; LA &gt; FeLA).	Iron	11-13	UTP25 small subunit processome component	Rattus norvegicus	83-86
21543028-9	2011	Oral iron supplementation was effective, especially in patients with eGFR &lt; 30 ml/min/1.73 m2.	Iron	5-9	CD59 molecule (CD59 blood group)	Homo sapiens	85-90
21227589-2	2011	In the present study, the evaporation behavior and accompanying artifacts are examined for the super-cell lattice structure of L1(0) FePt, where alternating Fe and Pt planes exist in the [0 0 1] orientation.	Iron	133-135	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	127-132
21441512-9	2011	We showed that human beta-defensins 2 and 3, human cathelicidin LL-37, human neutrophil protein 1, and melittin displaced heme bound to SapA, thus supporting a hierarchy wherein immune evasion supercedes even the needed iron acquisition functions of the Sap system.	Iron	220-224	SH2 domain containing 1A	Homo sapiens	136-139
21555278-4	2011	The mainstay of the formula market is iron-fortified cow"s milk, which may have a distinct variation in carbohydrate, protein, and fat sources, depending on the manufacturer.	Iron	38-42	Weaning weight-maternal milk	Bos taurus	59-63
21371898-2	2011	To identify mitochondrial iron transporters in Arabidopsis, we searched for proteins homologous to the Danio rerio (zebrafish) Mitoferrin2 MFRN2, a mitochondrial iron importer in non-erythroid cells.	Iron	26-30	solute carrier family 25 member 28	Danio rerio	127-138
21371898-2	2011	To identify mitochondrial iron transporters in Arabidopsis, we searched for proteins homologous to the Danio rerio (zebrafish) Mitoferrin2 MFRN2, a mitochondrial iron importer in non-erythroid cells.	Iron	26-30	solute carrier family 25 member 28	Danio rerio	139-144
21355094-8	2011	Furthermore, these results suggest that natural genetic variation in the human ortholog TMPRSS6 might modify the clinical penetrance of HFE-associated hereditary hemochromatosis, raising the possibility that pharmacologic inhibition of TMPRSS6 could attenuate iron loading in this disorder.	Iron	260-264	transmembrane serine protease 6	Homo sapiens	88-95
21695907-8	2011	CONCLUSION: Social mobilization and social marketing had a positive impact on the KAP of adult women in the iron deficient population.	Iron	108-112	napsin A aspartic peptidase	Homo sapiens	82-85
21378396-0	2011	Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.	Iron	9-13	mitogen-activated protein kinase 8	Homo sapiens	39-42
21378396-0	2011	Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.	Iron	9-13	mitogen-activated protein kinase 1	Homo sapiens	47-50
21378396-7	2011	Iron or N-acetylcysteine supplementation reversed Dp44mT-induced up-regulation of phospho-JNK, but only iron was able to reverse the effect of DFO on JNK.	Iron	0-4	mitogen-activated protein kinase 8	Homo sapiens	90-93
21378396-7	2011	Iron or N-acetylcysteine supplementation reversed Dp44mT-induced up-regulation of phospho-JNK, but only iron was able to reverse the effect of DFO on JNK.	Iron	104-108	mitogen-activated protein kinase 8	Homo sapiens	150-153
21378396-8	2011	Both iron chelators significantly reduced ASK1-thioredoxin complex formation, resulting in the increased phosphorylation of ASK1, which activates the JNK and p38 pathways.	Iron	5-9	mitogen-activated protein kinase 8	Homo sapiens	150-153
21378396-8	2011	Both iron chelators significantly reduced ASK1-thioredoxin complex formation, resulting in the increased phosphorylation of ASK1, which activates the JNK and p38 pathways.	Iron	5-9	mitogen-activated protein kinase 1	Homo sapiens	158-161
21378396-9	2011	Thus, dissociation of ASK1 could serve as an important signal for the phosphorylation of JNK and p38 activation observed after iron chelation.	Iron	127-131	mitogen-activated protein kinase 8	Homo sapiens	89-92
21378396-9	2011	Thus, dissociation of ASK1 could serve as an important signal for the phosphorylation of JNK and p38 activation observed after iron chelation.	Iron	127-131	mitogen-activated protein kinase 1	Homo sapiens	97-100
21378396-10	2011	Phosphorylation of JNK and p38 likely play an important role in mediating the cell cycle arrest and apoptosis induced by iron depletion.	Iron	121-125	mitogen-activated protein kinase 8	Homo sapiens	19-22
21378396-10	2011	Phosphorylation of JNK and p38 likely play an important role in mediating the cell cycle arrest and apoptosis induced by iron depletion.	Iron	121-125	mitogen-activated protein kinase 1	Homo sapiens	27-30
21355094-8	2011	Furthermore, these results suggest that natural genetic variation in the human ortholog TMPRSS6 might modify the clinical penetrance of HFE-associated hereditary hemochromatosis, raising the possibility that pharmacologic inhibition of TMPRSS6 could attenuate iron loading in this disorder.	Iron	260-264	transmembrane serine protease 6	Homo sapiens	236-243
21411349-5	2011	MATERIALS AND METHODS: Fifty-one patients with primary iron overload (transferrin saturation &gt;=50% in females and &gt;=60% in males) were selected.	Iron	55-59	transferrin	Homo sapiens	70-81
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	0-4	catalase	Homo sapiens	257-265
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	0-4	superoxide dismutase 1	Homo sapiens	270-290
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	0-4	superoxide dismutase 1	Homo sapiens	292-295
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	133-137	catalase	Homo sapiens	257-265
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	133-137	superoxide dismutase 1	Homo sapiens	270-290
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	133-137	superoxide dismutase 1	Homo sapiens	292-295
21345335-5	2011	Conversely, naringin supplementation arrested iron-induced depletion in the GSH contents, GSHPx, GST, SOD and catalase activities significantly.	Iron	46-50	superoxide dismutase 1	Homo sapiens	102-105
21345335-5	2011	Conversely, naringin supplementation arrested iron-induced depletion in the GSH contents, GSHPx, GST, SOD and catalase activities significantly.	Iron	46-50	catalase	Homo sapiens	110-118
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	96-100	TATA-box-binding protein	Sus scrofa	200-228
21333724-3	2011	AIM OF THE STUDY: Previous study indicated that Angelica sinensis polysaccharide (ASP) may promote plasma iron levels by suppressing the expression of hepcidin, a negative regulator of body iron metabolism, in the liver.	Iron	190-194	hepcidin antimicrobial peptide	Rattus norvegicus	151-159
21296883-4	2011	Iron chelation with desferrioxamine or inhibition of ryanodine receptor (RyR)-mediated calcium release with ryanodine-reduced calcium signal duration and prevented NMDA-induced ERK1/2 activation.	Iron	0-4	mitogen-activated protein kinase 3	Homo sapiens	177-183
21296883-6	2011	Iron addition to primary hippocampal cultures kept in calcium-free medium elicited calcium signals and stimulated ERK1/2 phosphorylation; RyR inhibition abolished these effects.	Iron	0-4	mitogen-activated protein kinase 3	Homo sapiens	114-120
21296883-6	2011	Iron addition to primary hippocampal cultures kept in calcium-free medium elicited calcium signals and stimulated ERK1/2 phosphorylation; RyR inhibition abolished these effects.	Iron	0-4	ryanodine receptor 1	Homo sapiens	138-141
21296883-9	2011	Together, these results suggest that hippocampal neurons require iron to generate RyR-mediated calcium signals after NMDA receptor stimulation, which in turn promotes ERK1/2 activation, an essential step of sustained LTP.	Iron	65-69	ryanodine receptor 1	Homo sapiens	82-85
21296883-9	2011	Together, these results suggest that hippocampal neurons require iron to generate RyR-mediated calcium signals after NMDA receptor stimulation, which in turn promotes ERK1/2 activation, an essential step of sustained LTP.	Iron	65-69	mitogen-activated protein kinase 3	Homo sapiens	167-173
21267477-6	2011	Iron-binding proteins exhibited a retention time for myoglobin (Mb) &lt; hemoglobin (Hb), which corresponded to the binding constants for ZrO(2)NPs.	Iron	0-4	myoglobin	Gallus gallus	53-62
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	96-100	TATA-box-binding protein	Sus scrofa	230-233
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	115-119	TATA-box-binding protein	Sus scrofa	200-228
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	115-119	TATA-box-binding protein	Sus scrofa	230-233
21120509-6	2011	Iron accumulation was attributable to prolonged upregulation of the transferrin receptor and to increased uptake of peripheral iron through a leaky blood-brain barrier.	Iron	0-4	transferrin	Rattus norvegicus	68-79
21292999-4	2011	Since CCR7 is expressed on activated dendritic cells and T cells and is well known to control their migration, we hypothesized that lack of CCR7 reduces or abolishes FE.	Iron	166-168	chemokine (C-C motif) receptor 7	Mus musculus	140-144
21292999-15	2011	CCR7 indirectly affects FE by inhibiting migration of activated dendritic cells and of T cells from the jejunum to the colon.	Iron	24-26	chemokine (C-C motif) receptor 7	Mus musculus	0-4
21303654-2	2011	Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization.	Iron	33-37	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-19
21303654-2	2011	Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization.	Iron	81-85	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-13
21303654-2	2011	Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization.	Iron	81-85	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-19
21303654-5	2011	Further, Nrf2 activation enhanced iron release from the J774.1 murine macrophage cell line.	Iron	34-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
21303654-6	2011	Previous studies showed that inflammatory stimuli, such as LPS, downregulates macrophage Fpn1 by transcriptional and hepcidin-mediated post-translational mechanisms leading to iron sequestration by macrophages.	Iron	176-180	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	89-93
21303654-9	2011	These results demonstrate that Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription and suggest that Nrf2 may control iron metabolism during inflammation.	Iron	46-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-35
21303654-9	2011	These results demonstrate that Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription and suggest that Nrf2 may control iron metabolism during inflammation.	Iron	46-50	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	83-87
21303654-9	2011	These results demonstrate that Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription and suggest that Nrf2 may control iron metabolism during inflammation.	Iron	46-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
21303654-9	2011	These results demonstrate that Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription and suggest that Nrf2 may control iron metabolism during inflammation.	Iron	141-145	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-35
21303654-9	2011	These results demonstrate that Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription and suggest that Nrf2 may control iron metabolism during inflammation.	Iron	141-145	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	83-87
21303654-9	2011	These results demonstrate that Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription and suggest that Nrf2 may control iron metabolism during inflammation.	Iron	141-145	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
21292994-8	2011	Atm(-/-) mice had increased protein tyrosine nitration and significantly higher Heme Oxygenase (decycling) 1 levels that were substantially increased by a high-iron diet.	Iron	160-164	heme oxygenase 1	Mus musculus	80-108
21292999-4	2011	Since CCR7 is expressed on activated dendritic cells and T cells and is well known to control their migration, we hypothesized that lack of CCR7 reduces or abolishes FE.	Iron	166-168	chemokine (C-C motif) receptor 7	Mus musculus	6-10
21303654-0	2011	Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.	Iron	38-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
21303654-0	2011	Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.	Iron	38-42	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-28
21303654-2	2011	Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization.	Iron	33-37	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-13
21455261-1	2011	Bacteria are able to survive in low-iron environments by sequestering this metal ion from iron-containing proteins and other biomolecules such as transferrin, lactoferrin, heme, hemoglobin, or other heme-containing proteins.	Iron	44-48	transferrin	Homo sapiens	146-157
21277054-7	2011	Due to high concentrations of Fe (&gt; 0.5 mg L-1), reductive dissolution of Fe oxides is believed to cause As release from aquifer sediments.	Iron	30-32	immunoglobulin kappa variable 1-16	Homo sapiens	46-49
21398376-14	2011	Furthermore, the decrease in transferrin receptor expression in the microvasculature in the presence of relative brain iron deficiency reported in restless legs syndrome brains may underlie the problems associated with brain iron acquisition in restless legs syndrome.	Iron	119-123	transferrin	Homo sapiens	29-40
21499539-5	2011	This review summarizes some key structural and functional properties of three central proteins dedicated to the Fe-S cluster assembly process: namely, the sulfide donor (cysteine desulfurase); iron donor (frataxin), and the iron-sulfur cluster scaffold protein (IscU/ISU).	Iron	112-116	iron-sulfur cluster assembly enzyme	Homo sapiens	262-266
21499539-5	2011	This review summarizes some key structural and functional properties of three central proteins dedicated to the Fe-S cluster assembly process: namely, the sulfide donor (cysteine desulfurase); iron donor (frataxin), and the iron-sulfur cluster scaffold protein (IscU/ISU).	Iron	193-197	iron-sulfur cluster assembly enzyme	Homo sapiens	262-266
21310544-7	2011	The radiation quality dependence of TGF-beta-mediated EMT was determined by use of 1 GeV/amu (gigaelectron volt/atomic mass unit) (56)Fe ion particles at the National Aeronautics and Space Administration"s Space Radiation Laboratory.	Iron	134-136	transforming growth factor beta 1	Homo sapiens	36-44
21235714-6	2011	Similar to RPE65, 13cIMH is a membrane-associated protein, requires all-trans retinyl ester as its intrinsic substrate, and its enzymatic activity is dependent on iron.	Iron	163-167	retinoid isomerohydrolase RPE65 b	Danio rerio	18-24
21429441-0	2011	Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy.	Iron	34-38	transferrin	Homo sapiens	16-27
21128733-3	2011	Under conditions where the sixth coordination position at the cytochrome c heme iron becomes more accessible for exogenous ligands (by carboxymethylation, cardiolipin addition or by partial denaturation with guanidinium hydrochloride) this peroxidase activity is enhanced.	Iron	80-84	cytochrome c, somatic	Homo sapiens	62-74
21177266-5	2011	Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage.	Iron	0-4	transferrin	Homo sapiens	174-185
21267611-11	2011	Co-incubation of BEAS-2B cells with both gadolinium and iron resulted in diminished release of IL-8 relative to levels of the cytokine following incubation with gadolinium alone.	Iron	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21177266-5	2011	Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage.	Iron	53-57	transferrin	Homo sapiens	174-185
21177266-5	2011	Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage.	Iron	149-153	transferrin	Homo sapiens	174-185
21364282-3	2011	Efficient and specific depletion of miR-122 by injection of a locked-nucleic-acid-modified (LNA-modified) anti-miR into WT mice caused systemic iron deficiency, characterized by reduced plasma and liver iron levels, mildly impaired hematopoiesis, and increased extramedullary erythropoiesis in the spleen.	Iron	144-148	microRNA 615	Mus musculus	36-39
21177266-6	2011	Transferrin-bound iron enters target cells-mainly erythroid cells, but also immune and hepatic cells-via receptor-mediated endocytosis.	Iron	18-22	transferrin	Homo sapiens	0-11
21177266-8	2011	Iron will be later exported from macrophages to transferrin.	Iron	0-4	transferrin	Homo sapiens	48-59
21177266-10	2011	As transferrin becomes saturated in iron-overload states, excess iron is transported to the liver, the other main storage organ for iron, carrying the risk of free radical formation and tissue damage.	Iron	36-40	transferrin	Homo sapiens	3-14
21177266-10	2011	As transferrin becomes saturated in iron-overload states, excess iron is transported to the liver, the other main storage organ for iron, carrying the risk of free radical formation and tissue damage.	Iron	65-69	transferrin	Homo sapiens	3-14
21177266-10	2011	As transferrin becomes saturated in iron-overload states, excess iron is transported to the liver, the other main storage organ for iron, carrying the risk of free radical formation and tissue damage.	Iron	65-69	transferrin	Homo sapiens	3-14
21177268-7	2011	As transferrin becomes saturated in iron overload states, non-transferrin bound iron appears.	Iron	36-40	transferrin	Homo sapiens	3-14
21177268-7	2011	As transferrin becomes saturated in iron overload states, non-transferrin bound iron appears.	Iron	80-84	transferrin	Homo sapiens	3-14
21177268-11	2011	Increased transferrin saturation and/or ferritin levels are the main cues for further investigation of iron overload.	Iron	103-107	transferrin	Homo sapiens	10-21
21346101-2	2011	Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2.	Iron	0-4	transmembrane serine protease 6	Homo sapiens	102-114
21191310-8	2011	Hepatic expression of hepcidin, a central regulator of iron metabolism, was downregulated in both IDA and heart failure groups.	Iron	55-59	hepcidin antimicrobial peptide	Rattus norvegicus	22-30
21346101-3	2011	Mutations in DMT1 and matriptase-2 cause iron deficiency; mutations in FPN, HFE, and TRF2 cause iron excess.	Iron	41-45	transmembrane serine protease 6	Homo sapiens	22-34
21346101-6	2011	Integration of the IRE-RNA in translation regulators (near the cap) or turnover elements (after the coding region) increases iron uptake (DMT1/TRF1) or decreases iron storage/efflux (FTN/FPN) when IRP binds.	Iron	125-129	telomeric repeat binding factor 1	Homo sapiens	143-147
21177636-9	2011	The low transferrin concentrations and the presence of NTBI in CF and AF suggest that transferrin-independent iron transfer is important in early gestation.	Iron	110-114	transferrin	Homo sapiens	8-19
21177636-9	2011	The low transferrin concentrations and the presence of NTBI in CF and AF suggest that transferrin-independent iron transfer is important in early gestation.	Iron	110-114	transferrin	Homo sapiens	86-97
21254233-2	2011	Unlike myoglobin, Cgb displays a hexa-coordinated (bis-hystidyl) heme iron atom, having the heme distal His81(E7) residue as the endogenous sixth ligand.	Iron	70-74	cytoglobin	Homo sapiens	18-21
21219335-4	2011	Arabidopsis halleri shows low expression of the Fe acquisition and deficiency response-related genes IRT1 and IRT2 compared with A. thaliana.	Iron	48-50	iron regulated transporter 2	Arabidopsis thaliana	110-114
21219335-5	2011	In A. thaliana, lowering the expression of IRT1 and IRT2 through the addition of excess Fe to the medium increases Zn tolerance.	Iron	88-90	iron regulated transporter 2	Arabidopsis thaliana	52-56
21248200-1	2011	Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis.	Iron	102-106	solute carrier family 25 member 28	Danio rerio	35-47
21248200-1	2011	Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis.	Iron	102-106	solute carrier family 25 member 28	Danio rerio	49-54
21248200-1	2011	Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis.	Iron	102-106	solute carrier family 25 member 28	Danio rerio	56-64
21325349-3	2011	Therefore, these patients may require intravenous iron to sustain adequate treatment with erythropoietin-stimulating agents.	Iron	50-54	erythropoietin	Homo sapiens	90-104
21298748-1	2011	BACKGROUND: For decades, parenteral iron has been used in patients with iron deficiency unresponsive to oral iron therapy and in hemodialysis-dependent patients receiving erythropoietin.	Iron	36-40	erythropoietin	Homo sapiens	171-185
21422745-6	2011	Transferrin and TFR2 are important in iron homeostasis.	Iron	38-42	transferrin	Homo sapiens	0-11
21297151-12	2011	Interleukin-6 levels correlated with iron levels (r=-0.6, p=0.006) and transferrin saturations (r=-0.68, p=0.001) in idiopathic PAH but not in CTEPH.	Iron	37-41	interleukin 6	Homo sapiens	0-13
21586231-1	2011	OBJECTIVE: To study the mechanism of how iron-regulatory protein (hepcidin) affect iron overload in alcoholic liver disease (ALD).	Iron	41-45	hepcidin antimicrobial peptide	Rattus norvegicus	66-74
21483845-10	2011	An association between total iron binding capacity and SNP rs3811647 in the TF gene (GWAS observed P=7.0x10(-9), corrected P=0.012) was replicated within the VA samples (observed P=0.012).	Iron	29-33	transferrin	Homo sapiens	76-78
21453502-1	2011	BACKGROUND: Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer cell growth.	Iron	156-160	transferrin	Homo sapiens	50-61
21453502-7	2011	LS081 also increased the uptake of Fe from transferrin (Tf).	Iron	35-37	transferrin	Homo sapiens	43-54
21314147-1	2011	Metallation of hexahydropyrimidopyrimidine (hppH) by [Fe{N(SiMe(3))(2)}(2)] (1) produces the trimetallic iron(II) amide cage complex [{(Me(3)Si)(2)NFe}(2)(hpp)(4)Fe] (2), which contains three iron(II) centers, each of which resides in a distorted tetrahedral environment.	Iron	54-56	familial progressive hyperpigmentation 1	Homo sapiens	44-47
21473032-0	2004	Magnetic iron microbeads coupled with HEA-125 monoclonal antibody against epithelial cell adhesion molecule Magnetic iron microbeads coupled with HEA-125 monoclonal antibody against the epithelial cell adhesion molecule (EpCAM), abbreviated as EpCAM microbeads, have been developed primarily for the positive selection or depletion of EpCAM-positive cells (1, 2).	Iron	117-121	epithelial cell adhesion molecule	Homo sapiens	74-107
20888711-3	2011	Here, we investigated the abilities of six members of the A. minor/"porcitonsillarum" complex to acquire iron from transferrin and various haemoglobins.	Iron	105-109	transferrin	Homo sapiens	115-126
21314147-1	2011	Metallation of hexahydropyrimidopyrimidine (hppH) by [Fe{N(SiMe(3))(2)}(2)] (1) produces the trimetallic iron(II) amide cage complex [{(Me(3)Si)(2)NFe}(2)(hpp)(4)Fe] (2), which contains three iron(II) centers, each of which resides in a distorted tetrahedral environment.	Iron	105-109	familial progressive hyperpigmentation 1	Homo sapiens	44-47
21166655-4	2011	Through EPR and UV-visible spectroscopy studies, we address the Fe-binding environment of the proposed catalytic centre of wild-type ALKBH4 and an Fe(II)-binding mutant.	Iron	64-66	alkB homolog 4, lysine demethylase	Homo sapiens	133-139
21166655-8	2011	We also report the presence of a unique cysteine-rich motif conserved in the N-terminus of ALKBH4 orthologues, and investigate its possible Fe-binding ability.	Iron	140-142	alkB homolog 4, lysine demethylase	Homo sapiens	91-97
21166655-11	2011	The present results demonstrate that ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination.	Iron	65-67	alkB homolog 4, lysine demethylase	Homo sapiens	37-43
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	39-43	transferrin	Homo sapiens	72-83
21348856-3	2011	Iron is delivered to tissues by circulating transferrin, a transporter that captures iron released into the plasma mainly from intestinal enterocytes or reticuloendothelial macrophages.	Iron	0-4	transferrin	Homo sapiens	44-55
21348856-3	2011	Iron is delivered to tissues by circulating transferrin, a transporter that captures iron released into the plasma mainly from intestinal enterocytes or reticuloendothelial macrophages.	Iron	85-89	transferrin	Homo sapiens	44-55
21348856-4	2011	The binding of iron-laden transferrin to the cell-surface transferrin receptor 1 results in endocytosis and uptake of the metal cargo.	Iron	15-19	transferrin	Homo sapiens	26-37
21348856-4	2011	The binding of iron-laden transferrin to the cell-surface transferrin receptor 1 results in endocytosis and uptake of the metal cargo.	Iron	15-19	transferrin	Homo sapiens	58-69
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	206-210	transferrin	Homo sapiens	72-83
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	33-37
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	0-4	BTB domain and CNC homolog 1	Homo sapiens	115-126
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	180-184	iron responsive element binding protein 2	Homo sapiens	33-37
22545184-5	2011	Recently, the multi-functional IL-6 is emerging as an important factor able to modulate bone, iron and inflammatory homeostasis.Here, we report an overview of Lf functions as well as for the first time Lf anti-inflammatory ability against periodontitis in in vitro model and observational clinical study.	Iron	94-98	interleukin 6	Homo sapiens	31-35
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	180-184	BTB domain and CNC homolog 1	Homo sapiens	115-126
21208937-3	2011	We identified and replicated a novel association of a common variant in the type-2 transferrin receptor (TFR2) gene with iron levels, with effect sizes highly consistent across samples.	Iron	121-125	transferrin	Homo sapiens	83-94
21208937-7	2011	These functional findings require confirmation in further studies with larger sample sizes, but they suggest that common variants in TMPRSS6 could modify the hepcidin-iron feedback loop in clinically unaffected individuals, thus making them more susceptible to imbalances of iron homeostasis.	Iron	167-171	transmembrane serine protease 6	Homo sapiens	133-140
21208937-7	2011	These functional findings require confirmation in further studies with larger sample sizes, but they suggest that common variants in TMPRSS6 could modify the hepcidin-iron feedback loop in clinically unaffected individuals, thus making them more susceptible to imbalances of iron homeostasis.	Iron	275-279	transmembrane serine protease 6	Homo sapiens	133-140
21408141-6	2011	Elevations in serum Hep-1 and urine Hep-2 upon intravenous iron or LPS were only moderate and varied considerably between mouse strains.	Iron	59-63	DNL-type zinc finger	Mus musculus	20-25
21408141-9	2011	Furthermore, serum Hep-1 appeared to be an excellent indicator of splenic iron accumulation.	Iron	74-78	DNL-type zinc finger	Mus musculus	19-24
21149632-7	2011	Erythropoietin significantly increased (P &lt; .001) within 16 hours after hypoxia exposure followed by a marked erythropoietic response supported by the increased iron supply.	Iron	164-168	erythropoietin	Homo sapiens	0-14
20862564-7	2011	Additionally, when used at a non-cytotoxic concentration (100 muM), these compounds showed significant effectiveness in preventing iron-induced oxidative stress, resulting in a reduction of 30%, 36% and 38% in thiobarbituric acid-reactive substance production, respectively.	Iron	131-135	latexin	Homo sapiens	62-65
20957368-4	2011	The CyaY protein can bind ferric iron and serve as an iron donor for the biogenesis of iron-sulfur clusters on the scaffold protein IscU in the presence of IscS and L-cysteine in vitro.	Iron	33-37	iron-sulfur cluster assembly enzyme	Homo sapiens	132-136
21183736-3	2011	METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler.	Iron	37-41	interleukin 6	Homo sapiens	147-160
21093478-0	2011	Molecular responses of calreticulin genes to iron overload and bacterial challenge in channel catfish (Ictalurus punctatus).	Iron	45-49	calreticulin 3a	Ictalurus punctatus	23-35
21093478-6	2011	The objective of this study, therefore, was to characterize the calreticulin gene from channel catfish, to determine its genomic organization, to profile its patterns of tissue expression, and to establish its potential for physiological antioxidant and immune responses in catfish after bacterial infection with Edwardsiella ictaluri and iron treatment.	Iron	339-343	calreticulin 3a	Ictalurus punctatus	64-76
21075070-11	2011	The results could be significant with regard to our understanding of iron-catalyzed C-H hydroxylation, the observation of P450-dependent peroxidation and the development of oxidative stress, especially for CYP2E1.	Iron	69-73	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	206-212
21147210-0	2011	Recombinant human transferrin: beyond iron binding and transport.	Iron	38-42	transferrin	Homo sapiens	18-29
21147210-2	2011	Transferrin (Tf) is a ubiquitous protein with a central role in iron transport and metabolism.	Iron	64-68	transferrin	Homo sapiens	0-11
21147210-2	2011	Transferrin (Tf) is a ubiquitous protein with a central role in iron transport and metabolism.	Iron	64-68	transferrin	Homo sapiens	13-15
21147210-3	2011	There is evidence, however, that Tf has many other biological roles in addition to its primary function of facilitating iron transport and metabolism, such as its profound effect on mammalian cell growth and productivity.	Iron	120-124	transferrin	Homo sapiens	33-35
21093478-8	2011	The three calreticulin genes are widely expressed in various tissues under homeostatic conditions and their expression showed significant upregulation following infection and/or iron level changes.	Iron	178-182	calreticulin 3a	Ictalurus punctatus	10-22
20957368-4	2011	The CyaY protein can bind ferric iron and serve as an iron donor for the biogenesis of iron-sulfur clusters on the scaffold protein IscU in the presence of IscS and L-cysteine in vitro.	Iron	54-58	iron-sulfur cluster assembly enzyme	Homo sapiens	132-136
21076126-5	2011	RESULTS: TNF(DeltaARE/WT) mice develop severe inflammation of the distal ileum but remained completely healthy when transferred to an iron sulfate free diet, even if iron was systemically repleted.	Iron	134-138	tumor necrosis factor	Mus musculus	9-12
21365550-1	2011	Transferrin (Tf) is a beta-globulin protein that transports iron ions in mammalian cells.	Iron	60-64	transferrin	Homo sapiens	0-11
21198378-2	2011	For this reason, a novel polymerase chain reaction multiplex SNaPshot reaction has been developed that targets 10 autosomal mutations in genes, or regions near to them, reported to be involved in iron metabolism: TMPRSS6, TF, and HFE.	Iron	196-200	transmembrane serine protease 6	Homo sapiens	213-220
21365550-1	2011	Transferrin (Tf) is a beta-globulin protein that transports iron ions in mammalian cells.	Iron	60-64	transferrin	Homo sapiens	13-15
21149283-3	2011	The PCSK7 association was the most significant (rs236918, P = 1.1 x 10E-27) suggesting that proprotein convertase 7, the gene product of PCSK7, may be involved in sTfR generation and/or iron homeostasis.	Iron	186-190	proprotein convertase subtilisin/kexin type 7	Homo sapiens	4-9
21149283-3	2011	The PCSK7 association was the most significant (rs236918, P = 1.1 x 10E-27) suggesting that proprotein convertase 7, the gene product of PCSK7, may be involved in sTfR generation and/or iron homeostasis.	Iron	186-190	proprotein convertase subtilisin/kexin type 7	Homo sapiens	92-115
21149283-3	2011	The PCSK7 association was the most significant (rs236918, P = 1.1 x 10E-27) suggesting that proprotein convertase 7, the gene product of PCSK7, may be involved in sTfR generation and/or iron homeostasis.	Iron	186-190	proprotein convertase subtilisin/kexin type 7	Homo sapiens	137-142
20556443-4	2011	Increased expression of divalent metal transporter 1 and decreased expression of ferroportin 1 might associate with this increased nigral iron levels.	Iron	138-142	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	81-94
21373260-5	2011	To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferroportin in its export.	Iron	12-16	transferrin	Homo sapiens	30-41
21373260-5	2011	To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferroportin in its export.	Iron	12-16	transferrin	Homo sapiens	46-57
21373260-5	2011	To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferroportin in its export.	Iron	108-112	transferrin	Homo sapiens	30-41
21373260-5	2011	To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferroportin in its export.	Iron	108-112	transferrin	Homo sapiens	46-57
20701626-0	2011	Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-alpha and ERK activation.	Iron	0-4	tumor necrosis factor	Homo sapiens	97-106
20701626-0	2011	Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-alpha and ERK activation.	Iron	0-4	mitogen-activated protein kinase 1	Homo sapiens	111-114
20701626-8	2011	Additional activation of ERKs by iron contributed to the synergistic increases.	Iron	33-37	mitogen-activated protein kinase 1	Homo sapiens	25-29
20701626-10	2011	Our results indicate that iron and UVA increase MMP-1 activity in dermal fibroblasts not only directly through ERK activation but also by an indirect paracrine loop through TNF-alpha released by NHEK.	Iron	26-30	mitogen-activated protein kinase 1	Homo sapiens	111-114
20701626-10	2011	Our results indicate that iron and UVA increase MMP-1 activity in dermal fibroblasts not only directly through ERK activation but also by an indirect paracrine loop through TNF-alpha released by NHEK.	Iron	26-30	tumor necrosis factor	Homo sapiens	173-182
20851655-6	2011	Iron metabolism, absorption, diffusion, storage, and use by the bone marrow are described using published data on transferrin, ferritin, and hepcidin.	Iron	0-4	transferrin	Homo sapiens	114-125
21318635-1	2011	The iron storage proteins, ferritin and hemosiderin, enable electron microscopic visualization thanks to their electron-dense iron content, which is not present in other compounds involved in transport or metabolism of iron such as transferrin, lactoferrin, or hemoglobin.	Iron	4-8	transferrin	Homo sapiens	232-243
21161302-13	2011	Moreover, transferrin/transferrin receptor 2 mediated transport of iron into the mitochondria of these neurons was identified together with increased transferrin immunoreactivity.	Iron	67-71	transferrin	Homo sapiens	10-21
21161302-13	2011	Moreover, transferrin/transferrin receptor 2 mediated transport of iron into the mitochondria of these neurons was identified together with increased transferrin immunoreactivity.	Iron	67-71	transferrin	Homo sapiens	22-33
20851655-14	2011	IL-6 diminishes the proportion of nucleated erythroid cells in the bone marrow and lowers the serum iron level, and these abnormalities can be corrected by administering an IL-6 antagonist.	Iron	100-104	interleukin 6	Homo sapiens	0-4
20851655-14	2011	IL-6 diminishes the proportion of nucleated erythroid cells in the bone marrow and lowers the serum iron level, and these abnormalities can be corrected by administering an IL-6 antagonist.	Iron	100-104	interleukin 6	Homo sapiens	173-177
21210042-3	2011	We report here on the interactions of iron saturated human transferrin protein with both bare and polyvinyl alcohol coated superparamagnetic iron oxide nanoparticles (SPIONs).	Iron	38-42	transferrin	Homo sapiens	59-70
21342472-2	2011	In addition to the biological role of desferrioxamines (dFOs) as hydroxamate siderophores, and the pharmaceutical application of dFO-B as an iron-chelator, the ferrioxamines have been shown to mediate microbial interactions.	Iron	141-145	Vacuolar protein sorting 16B	Drosophila melanogaster	129-134
21211566-12	2011	Immunoprecipitates of homogenates of the optic nerve revealed that (59)Fe was precipitable with an antibody raised against ferritin, indicative of detachment of iron from transferrin within the axons of the retinal ganglion cells.	Iron	71-73	transferrin	Rattus norvegicus	171-182
20423745-1	2011	Increased serum ferritin concentrations in nonpathologic conditions, reflecting subclinical iron overload, have been reported to be associated with insulin resistance and an increased risk of type 2 diabetes mellitus (DM).	Iron	92-96	insulin	Homo sapiens	148-155
20423745-17	2011	These results suggest that iron overload is associated with insulin resistance in men, but not in women.	Iron	27-31	insulin	Homo sapiens	60-67
21210042-4	2011	The exposure of human transferrin to SPIONs results in the release of iron, which changes the main function of the protein, which is the transport of iron among cells.	Iron	70-74	transferrin	Homo sapiens	22-33
21210042-4	2011	The exposure of human transferrin to SPIONs results in the release of iron, which changes the main function of the protein, which is the transport of iron among cells.	Iron	150-154	transferrin	Homo sapiens	22-33
21851051-7	2011	The obtained data shows that under NO hyperproduction certain changes in iron metabolism take place, such as: the decrease of transferrin iron and the accumulation of ferric iron not bound with transferrin.	Iron	73-77	transferrin	Rattus norvegicus	126-137
20826742-6	2011	However, 48 h after intravenous iron administration, we observed a transient increase of tumour necrosis factor-alpha and interleukin-6 formation by unstimulated monocytes as compared with control subjects.	Iron	32-36	interleukin 6	Homo sapiens	122-135
20696680-7	2011	Five days after the IV administration of 200 mg iron sucrose, a significant increase of RTC was observed, only in those patients with elevated baseline CRP levels who also showed an increase in CHr levels from &lt;= 31.2 pg at baseline to &gt;= 31.2 pg post-administration, supporting the presence of an independent positive correlation between CRP and RTC when iron is adequate.	Iron	48-52	C-reactive protein	Homo sapiens	152-155
20696680-7	2011	Five days after the IV administration of 200 mg iron sucrose, a significant increase of RTC was observed, only in those patients with elevated baseline CRP levels who also showed an increase in CHr levels from &lt;= 31.2 pg at baseline to &gt;= 31.2 pg post-administration, supporting the presence of an independent positive correlation between CRP and RTC when iron is adequate.	Iron	48-52	C-reactive protein	Homo sapiens	345-348
21705976-5	2011	When the iron binding capacity of transferrin is saturated, iron can appear in the serum in a free form, called Non-Transferrin-Bound Iron, a powerful catalyst for the formation of free radicals, capable of causing oxidative stress and damage to mitochondria, lysosomes, lipid membranes, proteins, and DNA.	Iron	9-13	transferrin	Homo sapiens	34-45
21705976-5	2011	When the iron binding capacity of transferrin is saturated, iron can appear in the serum in a free form, called Non-Transferrin-Bound Iron, a powerful catalyst for the formation of free radicals, capable of causing oxidative stress and damage to mitochondria, lysosomes, lipid membranes, proteins, and DNA.	Iron	9-13	transferrin	Homo sapiens	116-127
21705976-5	2011	When the iron binding capacity of transferrin is saturated, iron can appear in the serum in a free form, called Non-Transferrin-Bound Iron, a powerful catalyst for the formation of free radicals, capable of causing oxidative stress and damage to mitochondria, lysosomes, lipid membranes, proteins, and DNA.	Iron	60-64	transferrin	Homo sapiens	34-45
21705976-5	2011	When the iron binding capacity of transferrin is saturated, iron can appear in the serum in a free form, called Non-Transferrin-Bound Iron, a powerful catalyst for the formation of free radicals, capable of causing oxidative stress and damage to mitochondria, lysosomes, lipid membranes, proteins, and DNA.	Iron	60-64	transferrin	Homo sapiens	116-127
21705976-5	2011	When the iron binding capacity of transferrin is saturated, iron can appear in the serum in a free form, called Non-Transferrin-Bound Iron, a powerful catalyst for the formation of free radicals, capable of causing oxidative stress and damage to mitochondria, lysosomes, lipid membranes, proteins, and DNA.	Iron	134-138	transferrin	Homo sapiens	34-45
21705976-5	2011	When the iron binding capacity of transferrin is saturated, iron can appear in the serum in a free form, called Non-Transferrin-Bound Iron, a powerful catalyst for the formation of free radicals, capable of causing oxidative stress and damage to mitochondria, lysosomes, lipid membranes, proteins, and DNA.	Iron	134-138	transferrin	Homo sapiens	116-127
21705980-3	2011	The duration of the disease, the patient"s age and the severity of iron overload are the most important factors responsible for the defect of growth hormone (GH) secretion.	Iron	67-71	growth hormone 1	Homo sapiens	142-156
21705989-2	2011	The insufficient production of parathyroid hormone is mainly due to iron overload in parathyroid glands.	Iron	68-72	parathyroid hormone	Homo sapiens	31-50
21851051-7	2011	The obtained data shows that under NO hyperproduction certain changes in iron metabolism take place, such as: the decrease of transferrin iron and the accumulation of ferric iron not bound with transferrin.	Iron	73-77	transferrin	Rattus norvegicus	194-205
21851051-7	2011	The obtained data shows that under NO hyperproduction certain changes in iron metabolism take place, such as: the decrease of transferrin iron and the accumulation of ferric iron not bound with transferrin.	Iron	138-142	transferrin	Rattus norvegicus	126-137
21250651-9	2011	In the oropharyngeal aspiration model in the mouse, iron doping was associated with decreased polymorphonuclear cell counts and IL-6 mRNA production.	Iron	52-56	interleukin 6	Mus musculus	128-132
21189251-5	2011	Overexpressing the major mitochondrial phosphate carrier, MIR1, slightly increased the concentration of soluble mitochondrial phosphate and significantly improved various mitochondrial functions (cytochromes, [Fe-S] clusters, and respiration) in Deltayfh1 cells.	Iron	210-214	Mir1p	Saccharomyces cerevisiae S288C	58-62
21167257-0	2011	Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron.	Iron	78-82	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	27-47
21320324-11	2011	CONCLUSIONS: These studies have therefore confirmed that the IREB2 locus is a contributor to COPD susceptibility and suggests a new pathway in COPD pathogenesis invoking iron homeostasis.	Iron	170-174	iron responsive element binding protein 2	Homo sapiens	61-66
21281640-1	2011	Iron regulatory protein 2 (IRP2) is a critical switch for cellular and systemic iron homeostasis.	Iron	80-84	iron responsive element binding protein 2	Homo sapiens	0-25
21281640-1	2011	Iron regulatory protein 2 (IRP2) is a critical switch for cellular and systemic iron homeostasis.	Iron	80-84	iron responsive element binding protein 2	Homo sapiens	27-31
21281640-2	2011	In iron-deficient or hypoxic cells, IRP2 binds to mRNAs containing iron responsive elements (IREs) and regulates their expression.	Iron	3-7	iron responsive element binding protein 2	Homo sapiens	36-40
21281640-3	2011	Iron promotes proteasomal degradation of IRP2 via the F-box protein FBXL5.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	41-45
21281640-3	2011	Iron promotes proteasomal degradation of IRP2 via the F-box protein FBXL5.	Iron	0-4	F-box and leucine rich repeat protein 5	Homo sapiens	68-73
21281640-5	2011	We show that iron-dependent decay of tetracycline-inducible IRP2 proceeds efficiently under mild hypoxic conditions (3% oxygen) but is compromised in severe hypoxia (0.1% oxygen).	Iron	13-17	iron responsive element binding protein 2	Homo sapiens	60-64
21281640-6	2011	A treatment of cells with exogenous H(2)O(2) protects IRP2 against iron and increases its IRE-binding activity.	Iron	67-71	iron responsive element binding protein 2	Homo sapiens	54-58
21281640-8	2011	These data demonstrate that the degradation of IRP2 in iron-replete cells is not only oxygen-dependent but also sensitive to redox perturbations.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	47-51
21147099-0	2011	Iron chelation down-regulates dopamine transporter expression by decreasing mRNA stability and increasing endocytosis in N2a cells.	Iron	0-4	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	30-50
21147099-2	2011	Changes in the cellular labile iron pool (LIP) affect many cellular mechanisms including those that regulate DAT trafficking.	Iron	31-35	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	109-112
21147099-3	2011	In this study, we analyzed DAT expression and posttranslational modifications in response to changes in cellular iron in transfected neuroblastoma cells (N2a).	Iron	113-117	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	27-30
21147099-4	2011	Iron chelation by desferrioxamine (DFO) altered DAT protein levels by decreasing the stability of DAT mRNA.	Iron	0-4	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	48-51
21147099-4	2011	Iron chelation by desferrioxamine (DFO) altered DAT protein levels by decreasing the stability of DAT mRNA.	Iron	0-4	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	98-101
21147099-8	2011	Together, these findings suggest that cellular iron depletion regulates DAT expression through reducing mRNA stability as well as an increasing in endocytosis.	Iron	47-51	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	72-75
21147772-8	2011	These data support the hypothesis that iron delays the formation of well ordered aggregates of Abeta and so promotes its toxicity in Alzheimer disease.	Iron	39-43	amyloid beta precursor protein	Homo sapiens	95-100
21167257-1	2011	The specific activity of brain glutamine synthetase (GS) is lowered in several neurodegenerative diseases that involve iron-mediated oxidative stress.	Iron	119-123	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	31-51
20966077-0	2011	Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.	Iron	131-135	transmembrane serine protease 6	Homo sapiens	54-61
21170445-3	2011	Iron-carrying transferrin and ferritin proteins further form lanthanide complexes working as pH indicators and protein recognition reagents.	Iron	0-4	transferrin	Homo sapiens	14-25
21167174-12	2011	Furthermore, PHF2 shares significant sequence homology throughout the entire region, including the above-mentioned tyrosine at the corresponding iron-binding position, with that of Schizosaccharomyces pombe Epe1, which plays an essential role in heterochromatin function but has no known enzymatic activity.	Iron	145-149	PHD finger protein 2	Homo sapiens	13-17
21115478-4	2011	All genes identified as suppressors of high iron toxicity in aerobically grown Deltaccc1 cells encode organelle iron transporters including mitochondrial iron transporters MRS3, MRS4, and RIM2.	Iron	44-48	Fe(2+) transporter	Saccharomyces cerevisiae S288C	172-176
21115976-0	2011	Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein.	Iron	64-68	hepcidin antimicrobial peptide	Rattus norvegicus	23-31
21115976-7	2011	However, an increase in matriptase-2 protein in the liver from ID rats was detected, suggesting that suppression of hepcidin expression in response to acute iron deprivation is mediated by an increase in matriptase-2 protein levels.	Iron	157-161	hepcidin antimicrobial peptide	Rattus norvegicus	116-124
21115478-5	2011	Overexpression of MRS3 suppressed high iron toxicity by decreasing cytosolic iron through mitochondrial iron accumulation.	Iron	39-43	Fe(2+) transporter	Saccharomyces cerevisiae S288C	18-22
21115478-5	2011	Overexpression of MRS3 suppressed high iron toxicity by decreasing cytosolic iron through mitochondrial iron accumulation.	Iron	77-81	Fe(2+) transporter	Saccharomyces cerevisiae S288C	18-22
21115478-5	2011	Overexpression of MRS3 suppressed high iron toxicity by decreasing cytosolic iron through mitochondrial iron accumulation.	Iron	77-81	Fe(2+) transporter	Saccharomyces cerevisiae S288C	18-22
21236255-0	2011	Mechanistic characterization of sulfur transfer from cysteine desulfurase SufS to the iron-sulfur scaffold SufU in Bacillus subtilis.	Iron	86-90	SUFU negative regulator of hedgehog signaling	Homo sapiens	107-111
21115478-7	2011	We conclude that Mrs3/Mrs4 can sequester iron within mitochondria under aerobic conditions but not anaerobic conditions.	Iron	41-45	Fe(2+) transporter	Saccharomyces cerevisiae S288C	17-21
20195917-13	2011	The obtained results seem to indicate the association between lipid and glucose metabolism and iron, copper, zinc, and calcium concentrations in blood and hair of hypertensive and obese patients with insulin resistance.	Iron	95-99	insulin	Homo sapiens	200-207
20887817-2	2011	The PAS-A domain of mPer2 binds the heme iron via a Cys axial ligand.	Iron	41-45	period circadian clock 2	Mus musculus	20-25
21326867-1	2011	BACKGROUND: Mice irradiated and reconstituted with hematopoietic cells lacking manganese superoxide dismutase (SOD2) show a persistent hemolytic anemia similar to human sideroblastic anemia (SA), including characteristic intra-mitochondrial iron deposition.	Iron	241-245	superoxide dismutase 2, mitochondrial	Mus musculus	111-115
21326867-6	2011	Despite iron accumulation within mitochondria, we found increased expression of transferrin receptor, Tfrc, at both the transcript and protein level in SOD2 deficient cells, suggesting deregulation of iron delivery.	Iron	201-205	superoxide dismutase 2, mitochondrial	Mus musculus	152-156
21055448-1	2011	BACKGROUND: Lactoferrin is an iron-binding protein belonging to the transferrin family.	Iron	30-34	transferrin	Homo sapiens	68-79
20932353-5	2011	Fe deficiency diminished hepatic Fe content and CAT and GPx activities in hepatic cytosol only at day the 20.	Iron	0-2	catalase	Rattus norvegicus	48-51
21131439-4	2011	There are three types of iron-responsive transcriptional regulators in fungi; Aft1/Aft2 activators in yeast, GATA-type repressors in many fungi, and HapX/Php4 in Schizosaccharomyces pombe and Aspergillus species.	Iron	25-29	Aft2p	Saccharomyces cerevisiae S288C	83-87
20739232-4	2011	Whatever the cause, hepatocellular iron deposition promotes liver fibrogenesis, while an emerging possible aggravating factor is represented by the strong link between iron stores and insulin resistance, a recently recognized risk factor for the progression of liver diseases.	Iron	168-172	insulin	Homo sapiens	184-191
21145254-8	2011	In the obese women, serum transferrin receptor (a marker of iron status) and serum hepcidin were correlated with ex vivo stimulated IFNgamma production at baseline.	Iron	60-64	transferrin	Homo sapiens	26-37
21145254-8	2011	In the obese women, serum transferrin receptor (a marker of iron status) and serum hepcidin were correlated with ex vivo stimulated IFNgamma production at baseline.	Iron	60-64	interferon gamma	Homo sapiens	132-140
21145254-11	2011	Furthermore, iron status and serum hepcidin were associated with ex vivo LPS and ZY stimulated IFNgamma in obesity.	Iron	13-17	interferon gamma	Homo sapiens	95-103
21150441-5	2011	Novel genetic forms of iron-related microcytic anemia have been identified, due to defects of iron transport/utilization or to TMPRSS6 deficiency and hepcidin hyperproduction, as occurs in iron-refractory iron deficiency anemia (IRIDA).	Iron	23-27	transmembrane serine protease 6	Homo sapiens	127-134
21437029-3	2011	Iron trafficking depends largely on the transferrin cycle.	Iron	0-4	transferrin	Homo sapiens	40-51
20673806-10	2011	Genes involved in ergosterol biosynthesis, iron uptake, cell wall organization and capsule biosynthesis, in addition to NCR-sensitive genes, are Gat1-regulated in C. neoformans.	Iron	43-47	solute carrier family 6 member 1	Homo sapiens	145-149
20564534-10	2011	Although no correlation between FPN protein and IL-6 was noted, there was a strong negative correlation between serum iron and IL-6, both in subjects with CD (r=-0.88, P&lt;0.0001) and those without anemia (r=-0.58, P=0.02).	Iron	118-122	interleukin 6	Homo sapiens	127-131
21360641-2	2011	Iron regulatory proteins (IRPs, IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	41-45
21411831-3	2011	Here the authors investigate the hepcidin-involved iron absorption in exercise-associated anemia.	Iron	51-55	hepcidin antimicrobial peptide	Rattus norvegicus	33-41
21411831-12	2011	The data indicated that inflammation was induced by strenuous exercise, and as a result, the transcriptional level of the hepatic hepcidin gene was increased, which further inhibited the expression of iron-absorption proteins and led to exercise-associated anemia.	Iron	201-205	hepcidin antimicrobial peptide	Rattus norvegicus	130-138
21360641-2	2011	Iron regulatory proteins (IRPs, IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	81-85	iron responsive element binding protein 2	Homo sapiens	41-45
20938344-11	2011	Decreased plasma transferrin-bound iron levels were measured in the nonformulated gadodiamide group.	Iron	35-39	transferrin	Rattus norvegicus	17-28
21721439-9	2011	The significant rise in transferrin saturation indicates that this positive effect on erythropoietin response may be due to increased iron utilization.	Iron	134-138	transferrin	Homo sapiens	24-35
20015204-1	2011	Ferroportin 1 (FPN1) is an iron export protein expressed in liver and duodenum, as well as in reticuloendothelial macrophages.	Iron	27-31	solute carrier family 40 member 1	Rattus norvegicus	0-13
20015204-1	2011	Ferroportin 1 (FPN1) is an iron export protein expressed in liver and duodenum, as well as in reticuloendothelial macrophages.	Iron	27-31	solute carrier family 40 member 1	Rattus norvegicus	15-19
20015204-3	2011	We suggested that following receptor mediated endocytosis of transferrin filtered by the glomerulus, DMT1 exports iron liberated from transferrin into the cytosol.	Iron	114-118	transferrin	Rattus norvegicus	61-72
20015204-3	2011	We suggested that following receptor mediated endocytosis of transferrin filtered by the glomerulus, DMT1 exports iron liberated from transferrin into the cytosol.	Iron	114-118	transferrin	Rattus norvegicus	134-145
20015204-8	2011	These data support a role for FPN1 in vectorial export of iron out of PT cells.	Iron	58-62	solute carrier family 40 member 1	Rattus norvegicus	30-34
20015204-9	2011	Furthermore, under conditions of iron loading of cultured PT cells, FPN1 was trafficked to the plasma membrane suggesting a coordinated cellular response to export excess iron and limit cellular iron concentrations.	Iron	33-37	solute carrier family 40 member 1	Rattus norvegicus	68-72
20015204-9	2011	Furthermore, under conditions of iron loading of cultured PT cells, FPN1 was trafficked to the plasma membrane suggesting a coordinated cellular response to export excess iron and limit cellular iron concentrations.	Iron	171-175	solute carrier family 40 member 1	Rattus norvegicus	68-72
20015204-9	2011	Furthermore, under conditions of iron loading of cultured PT cells, FPN1 was trafficked to the plasma membrane suggesting a coordinated cellular response to export excess iron and limit cellular iron concentrations.	Iron	171-175	solute carrier family 40 member 1	Rattus norvegicus	68-72
21721439-9	2011	The significant rise in transferrin saturation indicates that this positive effect on erythropoietin response may be due to increased iron utilization.	Iron	134-138	erythropoietin	Homo sapiens	86-100
21348612-11	2011	Levels of hepcidin mRNA, which controls the supply of iron to the marrow in liver, were increased in ILS-infected rats; however, the concentration of serum iron did not change.	Iron	54-58	hepcidin antimicrobial peptide	Rattus norvegicus	10-18
21456267-3	2011	The reaction activity of ZVI particles was evaluated through decomposition experiments of NO3-N aqueous solution.	Iron	25-28	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
21034753-3	2011	Transferrin is unique in chelating iron with very high affinity while delivering it to cells as needed via receptor-mediated endocytosis.	Iron	35-39	transferrin	Homo sapiens	0-11
20738776-0	2011	Transferrin saturation as a predictor of hepatic iron overload.	Iron	49-53	transferrin	Homo sapiens	0-11
21456305-7	2011	Iron status was determined by serum parameters as follows: red blood cells count, hemoglobin concentration, serum iron and ferritin levels, an unsaturated iron binding capacity, total iron binding capacity and transferrin saturation.	Iron	0-4	transferrin	Homo sapiens	210-221
20851820-9	2011	CONCLUSION: Iron depletion by venesection favours the normalization of insulin resistance and raised liver enzymes in non-haemochromatosis patients with NAFLD.	Iron	12-16	insulin	Homo sapiens	71-78
21176945-1	2011	The activity of various anaerobic microbes, including sulfate reducers (SRB), iron reducers (FeRP) and methanogens (MPA) has been linked to mercury methylation in aquatic systems, although the relative importance of each microbial group in the overall process is poorly understood in natural sediments.	Iron	78-82	FER tyrosine kinase pseudogene 1	Homo sapiens	93-97
21044880-1	2011	As iron ions may participate in the pathogenesis of cancer and viral infections, the aim of this study was to monitor their influence on proliferation, E6 and E7 oncogene expression and reactive oxygen species (ROS) production in two human papilloma virus (HPV) positive cervical carcinoma cell lines (HeLa and SiHa) and one HPV negative vulvar cell line (A431).	Iron	3-7	E6	Human papillomavirus	152-161
21029046-5	2011	The two subunits co-ordinating the cluster are in a more extended conformation compared with iron-sulfur-bound human GLRX2, and the intersubunit interactions are more extensive and involve conserved residues among monothiol GLRXs.	Iron	93-97	glutaredoxin 2	Homo sapiens	117-122
21298097-4	2011	Through immunoprecipitation experiments, we show that the main endogenous interactors of a recombinant mature human frataxin are ISCU, NFS1 and ISD11, the components of the core Fe-S assembly complex.	Iron	178-182	iron-sulfur cluster assembly enzyme	Homo sapiens	129-133
21298097-4	2011	Through immunoprecipitation experiments, we show that the main endogenous interactors of a recombinant mature human frataxin are ISCU, NFS1 and ISD11, the components of the core Fe-S assembly complex.	Iron	178-182	LYR motif containing 4	Homo sapiens	144-149
21283681-1	2011	BACKGROUND/AIMS: Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism.	Iron	146-150	interleukin 6	Homo sapiens	47-51
21233389-3	2011	We identified a 5-LOX-specific destabilizing sequence that is involved in orienting the carboxyl terminus, which binds the catalytic iron.	Iron	133-137	arachidonate 5-lipoxygenase	Homo sapiens	16-21
20940420-5	2011	This finding suggests that elevated hepcidin levels in patients with familial iron-refractory, iron-deficiency anemia are the result of excess signaling through the Bmp6/Hjv pathway.	Iron	78-82	bone morphogenetic protein 6	Homo sapiens	165-169
21171611-12	2011	The induction of oxidative stress and inflammatory responses (evaluated by HO-1 mRNA expression and TNF-alpha mRNA and protein expression) revealed a reduction in inflammogenicity upon iron loading and a more inflammogenic potency of DQ12 ascribed to undissociated SiOH interacting via H-bonding with cell membrane components.	Iron	185-189	tumor necrosis factor	Homo sapiens	100-109
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	71-75	Aft2p	Saccharomyces cerevisiae S288C	118-122
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	152-156	Aft2p	Saccharomyces cerevisiae S288C	118-122
20978135-1	2011	The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae.	Iron	119-123	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	75-79
21842368-4	2011	HO-1 is a microsomal enzyme that catalyses the degradation of heme to iron, carbon monoxide and bilirubin.	Iron	70-74	heme oxygenase 1	Mus musculus	0-4
21725759-0	2011	Thrombin preconditioning reduces iron-induced brain swelling and brain atrophy.	Iron	33-37	coagulation factor II	Rattus norvegicus	0-8
21725759-1	2011	Cerebral preconditioning with a low dose of thrombin attenuates brain edema induced by intracerebral hemorrhage (ICH), a large dose of thrombin or iron.	Iron	147-151	coagulation factor II	Rattus norvegicus	44-52
21725765-0	2011	Thrombin preconditioning attenuates iron-induced neuronal death.	Iron	36-40	coagulation factor II, thrombin	Homo sapiens	0-8
21725765-10	2011	Preconditioning with thrombin or PAR agonists reduced iron-induced neuronal death (p&lt;0.05).	Iron	54-58	coagulation factor II, thrombin	Homo sapiens	21-29
22162689-3	2011	Linked with this pressure is the necessity of the embryo to obtain and transport iron, synthesize hemoglobin, and then dispose of the potentially toxic heme via the stress-induced protein heme oxygenase-1 (HO-1, encoded by Hmox1 in the mouse).	Iron	81-85	heme oxygenase 1	Mus musculus	188-204
22126026-3	2011	Iron is considered a putative element that interacts with oxygen radicals in inducing liver damage/fibrosis and insulin resistance.	Iron	0-4	insulin	Homo sapiens	112-119
22126026-5	2011	Though genetic factors, insulin resistance, dysregulation of iron-regulatory molecules, erythrophagocytosis by Kupffer cells may be responsible for hepatic iron accumulation in NASH, exact mechanisms involved in iron overload remain to be clarified.	Iron	156-160	insulin	Homo sapiens	24-31
22126026-6	2011	Iron reduction therapy such as phlebotomy or iron-restricted diet may be promising in patients with NAFLD/NASH to reduce hepatic injury as well as insulin resistance.	Iron	0-4	insulin	Homo sapiens	147-154
22126026-6	2011	Iron reduction therapy such as phlebotomy or iron-restricted diet may be promising in patients with NAFLD/NASH to reduce hepatic injury as well as insulin resistance.	Iron	45-49	insulin	Homo sapiens	147-154
21490768-0	2011	Uptake of non-transferrin iron by erythroid cells.	Iron	26-30	transferrin	Homo sapiens	14-25
21091174-2	2011	Iron metabolism can be described by a combination of biochemical soluble transferrin receptor, ferritin, C-reactive protein (CRP), and hematological parameters.	Iron	0-4	C-reactive protein	Homo sapiens	105-123
21091174-2	2011	Iron metabolism can be described by a combination of biochemical soluble transferrin receptor, ferritin, C-reactive protein (CRP), and hematological parameters.	Iron	0-4	C-reactive protein	Homo sapiens	125-128
21829009-6	2011	RESULTS: With adjustment for serial correlation in EPO dosing, hemoglobin, hospital admission and days, and intravenous iron administration were the strongest predictors of outpatient EPO dosing.	Iron	120-124	erythropoietin	Homo sapiens	184-187
21157922-1	2011	Heme oxygenase-1 (HO-1), which catalyzes the degradation of heme to iron, carbon monoxide, and biliverdin, performs a cytoprotective function.	Iron	68-72	heme oxygenase 1	Mus musculus	0-16
21490768-1	2011	Most of the iron in the plasma is bound to transferrin (Tf) and is taken up by cells through their surface Tf receptors (TfRs).	Iron	12-16	transferrin	Homo sapiens	43-54
21157922-1	2011	Heme oxygenase-1 (HO-1), which catalyzes the degradation of heme to iron, carbon monoxide, and biliverdin, performs a cytoprotective function.	Iron	68-72	heme oxygenase 1	Mus musculus	18-22
21157922-5	2011	In vivo, only Tg HO-1 G143H females presented with anemia, enlarged spleen and tissue iron overload, which was similar to HO-1(-/-) mice.	Iron	86-90	heme oxygenase 1	Mus musculus	17-21
21490768-1	2011	Most of the iron in the plasma is bound to transferrin (Tf) and is taken up by cells through their surface Tf receptors (TfRs).	Iron	12-16	transferrin	Homo sapiens	56-58
21490768-2	2011	Under pathological conditions of iron-overload, the plasma iron which is in excess of the binding capacity of Tf is present as non-Tf-bound iron.	Iron	33-37	transferrin	Homo sapiens	110-112
21490768-2	2011	Under pathological conditions of iron-overload, the plasma iron which is in excess of the binding capacity of Tf is present as non-Tf-bound iron.	Iron	59-63	transferrin	Homo sapiens	110-112
21490768-2	2011	Under pathological conditions of iron-overload, the plasma iron which is in excess of the binding capacity of Tf is present as non-Tf-bound iron.	Iron	59-63	transferrin	Homo sapiens	131-133
21490768-2	2011	Under pathological conditions of iron-overload, the plasma iron which is in excess of the binding capacity of Tf is present as non-Tf-bound iron.	Iron	59-63	transferrin	Homo sapiens	110-112
21490768-2	2011	Under pathological conditions of iron-overload, the plasma iron which is in excess of the binding capacity of Tf is present as non-Tf-bound iron.	Iron	59-63	transferrin	Homo sapiens	131-133
21490768-5	2011	Using flow cytometry techniques, we found that both the TfR-deficient mature RBC and their TfR-containing precursors at all stages of maturation can take up non-Tf iron that accumulates as redox-active labile iron and generates reactive oxygen species.	Iron	164-168	transferrin	Homo sapiens	56-58
22123640-8	2011	Iron in the developing fetus is accumulated against a concentration gradient and, in the case of maternal iron deficiency, the placenta can protect the fetus significantly through the increased expression of placental transferrin receptor together with a rise in divalent metal transporter 1 (DMT1).	Iron	0-4	transferrin	Homo sapiens	218-229
21490768-5	2011	Using flow cytometry techniques, we found that both the TfR-deficient mature RBC and their TfR-containing precursors at all stages of maturation can take up non-Tf iron that accumulates as redox-active labile iron and generates reactive oxygen species.	Iron	209-213	transferrin	Homo sapiens	56-58
22123642-2	2011	The likely explanation is that the rate of iron influx into the plasma from high-dose oral supplements exceeds the rate of iron binding to transferrin and a quantity of non-transferrin-bound iron (NTBI) is formed.	Iron	123-127	transferrin	Homo sapiens	139-150
22123642-2	2011	The likely explanation is that the rate of iron influx into the plasma from high-dose oral supplements exceeds the rate of iron binding to transferrin and a quantity of non-transferrin-bound iron (NTBI) is formed.	Iron	123-127	transferrin	Homo sapiens	139-150
20618233-6	2011	Iron doses were determined on the basis of values and changes of serum ferritin and transferrin saturation every fourth week after the longest interdialysis time interval.	Iron	0-4	transferrin	Homo sapiens	84-95
22024524-2	2011	It was reported recently that IL-6 is associated with insulin resistance, iron metabolism and interferon resistance, which may affect the outcome of antiviral treatment.	Iron	74-78	interleukin 6	Homo sapiens	30-34
20624491-2	2011	CPR shuttles electrons from NADPH through the FAD and FMN-coenzymes into the iron of the prosthetic heme-group of the CYP.	Iron	77-81	cytochrome p450 oxidoreductase	Homo sapiens	0-3
27975237-16	2011	Further analyses using multiple linear regressions indicated that the iron profiles (non-transferrin-bound iron and ferritin) were significant predictors of the pharmacokinetic parameters of non-conjugated deferiprone, deferiprone-chelated iron and UIE.	Iron	70-74	transferrin	Homo sapiens	89-100
20798152-6	2011	Levels of vascular endothelial growth factor (VEGF) were negatively related to depression (r = -.56) and intake of foods high in calcium (r = -.53) and iron (r = -.34) but positively related to serum calcium levels (r = .60).	Iron	152-156	vascular endothelial growth factor A	Homo sapiens	10-44
20798152-6	2011	Levels of vascular endothelial growth factor (VEGF) were negatively related to depression (r = -.56) and intake of foods high in calcium (r = -.53) and iron (r = -.34) but positively related to serum calcium levels (r = .60).	Iron	152-156	vascular endothelial growth factor A	Homo sapiens	46-50
22820082-1	2011	OBJECTIVE: The study sought to identify whether a relationship exists between serum myeloperoxidase (MPO) and free iron with stages of ovarian cancer.	Iron	115-119	myeloperoxidase	Homo sapiens	84-99
22820082-1	2011	OBJECTIVE: The study sought to identify whether a relationship exists between serum myeloperoxidase (MPO) and free iron with stages of ovarian cancer.	Iron	115-119	myeloperoxidase	Homo sapiens	101-104
20882311-0	2011	Iron status during anti-TNF therapy in children with juvenile idiopathic arthritis.	Iron	0-4	tumor necrosis factor	Homo sapiens	24-27
20882311-2	2011	The aim of the study was to evaluate the effect of anti-tumor necrosis factor (TNF) therapy on their iron status.	Iron	101-105	tumor necrosis factor	Homo sapiens	51-77
20882311-2	2011	The aim of the study was to evaluate the effect of anti-tumor necrosis factor (TNF) therapy on their iron status.	Iron	101-105	tumor necrosis factor	Homo sapiens	79-82
21028920-16	2011	Further analyses using multiple linear regressions indicated that the iron profiles (non-transferrin-bound iron and ferritin) were significant predictors of the pharmacokinetic parameters of non-conjugated deferiprone, deferiprone-chelated iron and UIE.	Iron	70-74	transferrin	Homo sapiens	89-100
22264719-2	2011	Hepcidin, a key regulator           of iron metabolism, is up-regulated by iron and inflammatory           stimuli such as interleukin 6, and decreased           by iron deficiency, enhanced erythropoiesis           and hypoxia.	Iron	39-43	interleukin 6	Mus musculus	123-136
21643505-5	2011	While ten of the metals tested (cadmium, cobalt, copper, gold, iron, lead, mercury, silver, sodium arsenite and zinc) stimulated Nrf2-dependent transcriptional activity in at least three of the engineered cell lines, only three (cadmium, copper and sodium arsenite) were active in all five cell lines.	Iron	63-67	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
20954800-3	2011	The addition of the iron chelator, desferrioxamine, to reduce the accumulation of ferric iron from heme by HO-1 resulted in a blockade of aggravated superoxide production.	Iron	20-24	heme oxygenase 1	Mus musculus	107-111
21373381-6	2011	RESULTS: An increase in Fe-transferrin signal was observed, suggesting blockage of Fe uptake.	Iron	24-26	transferrin	Homo sapiens	27-38
20951701-5	2011	Finally, a case-control study compared insulin and glucagon levels among dolphins with and without iron overload, a condition associated with insulin resistance in humans.	Iron	99-103	insulin	Homo sapiens	142-149
20854329-4	2011	The dearth of NO3- and SO42- in Lake Matano waters suggests that anaerobic methane oxidation may be coupled to the reduction of Fe (and/or Mn) (hydr)oxides.	Iron	128-130	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
21599430-5	2011	In 2008, specific combinations of L1 and deferoxamine (DFO) were reported to cause the complete removal of excess iron load and the achievement of normal range body iron store levels (NRBISL) in thalassemia patients.	Iron	114-118	immunoglobulin kappa variable 1-16	Homo sapiens	34-53
21599430-5	2011	In 2008, specific combinations of L1 and deferoxamine (DFO) were reported to cause the complete removal of excess iron load and the achievement of normal range body iron store levels (NRBISL) in thalassemia patients.	Iron	165-169	immunoglobulin kappa variable 1-16	Homo sapiens	34-53
21861815-2	2011	HIF-1, a heterodimer consisting of a constitutively expressed beta subunit and an oxygen-regulated alpha subunit, regulates a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival.	Iron	176-180	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
22615653-1	2011	BACKGROUND AND THE PURPOSE OF THE STUDY: sBesides its hematopoietic effects, erythropoietin (EPO) by mobilization of iron and modulation of some inflammatory cytokines has antioxidant and anti-inflammatory properties.	Iron	117-121	erythropoietin	Homo sapiens	77-91
22615653-1	2011	BACKGROUND AND THE PURPOSE OF THE STUDY: sBesides its hematopoietic effects, erythropoietin (EPO) by mobilization of iron and modulation of some inflammatory cytokines has antioxidant and anti-inflammatory properties.	Iron	117-121	erythropoietin	Homo sapiens	93-96
21034809-0	2011	beta-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.	Iron	41-45	amyloid beta precursor protein	Homo sapiens	0-20
21034809-2	2011	The abnormal interactions of Abeta with metal ions such as iron are implicated in the process of Abeta deposition and oxidative stress in AD brains.	Iron	59-63	amyloid beta precursor protein	Homo sapiens	29-34
21034809-2	2011	The abnormal interactions of Abeta with metal ions such as iron are implicated in the process of Abeta deposition and oxidative stress in AD brains.	Iron	59-63	amyloid beta precursor protein	Homo sapiens	97-102
21034809-3	2011	In this study, we observed that Abeta increased the levels of iron content and oxidative stress in SH-SY5Y cells overexpressing the Swedish mutant form of human beta-amyloid precursor protein (APPsw) and in Caenorhabditis elegans Abeta-expressing strain CL2006.	Iron	62-66	amyloid beta precursor protein	Homo sapiens	32-37
21034809-3	2011	In this study, we observed that Abeta increased the levels of iron content and oxidative stress in SH-SY5Y cells overexpressing the Swedish mutant form of human beta-amyloid precursor protein (APPsw) and in Caenorhabditis elegans Abeta-expressing strain CL2006.	Iron	62-66	amyloid beta precursor protein	Homo sapiens	161-191
21034809-8	2011	Furthermore, the C. elegans with Abeta-expression had increased iron accumulation.	Iron	64-68	amyloid beta precursor protein	Homo sapiens	33-38
21496614-7	2011	Brain iron is reduced in many, but not all, patients with RLS.	Iron	6-10	RLS1	Homo sapiens	58-61
21250883-8	2011	Serum ferritin also showed a positive correlation with elevated TBARS and SOD, suggesting that iron overload is involved in the oxidative stress shown in cells.	Iron	95-99	superoxide dismutase 1	Homo sapiens	74-77
21613741-6	2011	Moreover, our research provides the first in vivo evidence that HO-1 can enhance iron loading and tau (Ser199/202/396) phosphorylation in brains of transgenic mice.	Iron	81-85	heme oxygenase 1	Mus musculus	64-68
21086243-6	2011	Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress.	Iron	0-4	transferrin	Homo sapiens	37-48
22203913-6	2011	At the highest used concentration of iron ions Fe(3+) (100 muM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control.	Iron	37-41	latexin	Homo sapiens	59-62
22114506-6	2011	RESULTS: The splenocyte viability and the production of interleukin-2 and interleukin-4 were unaffected, whereas interferon-gamma production was markedly attenuated by iron oxide nanoparticles (10-100 mug iron/mL) in a concentration-dependent manner.	Iron	168-172	interleukin 4	Homo sapiens	74-87
22114506-6	2011	RESULTS: The splenocyte viability and the production of interleukin-2 and interleukin-4 were unaffected, whereas interferon-gamma production was markedly attenuated by iron oxide nanoparticles (10-100 mug iron/mL) in a concentration-dependent manner.	Iron	168-172	interferon gamma	Homo sapiens	113-129
21613741-7	2011	Cellular evidence indicates that HO-1 can induce the phosphorylation of tau through iron accumulation in Neuro2a cells stably transfected with HO-1.	Iron	84-88	heme oxygenase 1	Mus musculus	33-37
21613741-7	2011	Cellular evidence indicates that HO-1 can induce the phosphorylation of tau through iron accumulation in Neuro2a cells stably transfected with HO-1.	Iron	84-88	heme oxygenase 1	Mus musculus	143-147
20966191-10	2011	In addition, transferrin levels increased but the percentage of iron bound to transferrin and ferritin levels decreased.	Iron	64-68	transferrin	Homo sapiens	78-89
21613741-9	2011	This mechanism involves excessive iron production mediated by HO-1 overexpression, which induces tau phosphorylation.	Iron	34-38	heme oxygenase 1	Mus musculus	62-66
21196770-8	2011	Comparable changes in non-transferrin bound iron were 86 +- 42 versus 45 +- 45%, respectively (p &lt; 0.05).	Iron	44-48	transferrin	Homo sapiens	26-37
21297911-0	2011	Mysterious link between iron overload and CDKN2A/2B.	Iron	24-28	cyclin dependent kinase inhibitor 2A	Homo sapiens	42-51
21297911-6	2011	Through a combination of animal experiments and microarray analyses, homozygous deletion of CDKN2A/2B has been recognized as one of the major target genes involved in iron overload-induced carcinogenesis.	Iron	167-171	cyclin dependent kinase inhibitor 2A	Homo sapiens	92-101
20947636-3	2011	Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation of the proapoptotic regulator Bad (Ser136), and an increased Bax/Bcl-2 ratio.	Iron	70-74	AKT serine/threonine kinase 1	Homo sapiens	116-119
20947636-3	2011	Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation of the proapoptotic regulator Bad (Ser136), and an increased Bax/Bcl-2 ratio.	Iron	70-74	BCL2 associated X, apoptosis regulator	Homo sapiens	229-232
20947636-3	2011	Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation of the proapoptotic regulator Bad (Ser136), and an increased Bax/Bcl-2 ratio.	Iron	70-74	BCL2 apoptosis regulator	Homo sapiens	233-238
21874485-5	2011	Abeta peptides can be revealed histologically with specific dyes or antibodies, or by magnetic resonance microscopy (muMRI) that uses their association with iron as a source of signal.	Iron	157-161	histocompatibility 2, class II antigen A, beta 1	Mus musculus	0-5
20847004-1	2011	Transferrin (Tf) is a host glycoprotein capable of binding two ferric-iron ions to become holotransferrin (holoTf), which transports iron in to all cells.	Iron	70-74	transferrin	Homo sapiens	0-11
21469554-2	2011	Administration of intravenous iron therapy is important to maintain adequate serum ferritin and transferrin saturation levels for effective hemoglobin synthesis.	Iron	30-34	transferrin	Homo sapiens	96-107
21123956-11	2011	Hypoxia mimetic iron chelator deferroxamine promoted p53 accumulation in H9c2 myoblast cells by suppressing the Akt/MDM2 pathway, which was restored by ATR.	Iron	16-20	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
20558814-13	2011	Vit C status could play a major role in helping PD patients to utilize iron for erythropoiesis and achieve a better Hb response during anemia management.	Iron	71-75	vitrin	Homo sapiens	0-3
21346313-0	2011	Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis.	Iron	49-53	superoxide dismutase 1, soluble	Mus musculus	67-71
21346313-4	2011	METHODS AND RESULTS: In the present study, we applied the brain-permeable iron chelators VK-28 and M30 in a G93A mutant superoxide dismutase 1 transgenic (SOD1(G93A)) mouse model of ALS and found that VK-28 and M30 significantly delayed disease onset, extended the life span and reduced spinal cord motor neuron loss.	Iron	74-78	superoxide dismutase 1, soluble	Mus musculus	155-159
21346313-5	2011	Furthermore, we documented that both iron chelators significantly attenuated the elevated iron level and transferrin receptor expression, decreased oxygen free radicals and suppressed microglial and astrocytic activation in the spinal cords of the SOD1(G93A) mice.	Iron	37-41	superoxide dismutase 1, soluble	Mus musculus	248-252
21346313-6	2011	Moreover, we demonstrated that both iron chelators were able to decrease TDP-43 protein aggregation and the proapoptotic molecule Bax, and to enhance antiapoptotic protein Bcl-2 expression, in the ALS mice.	Iron	36-40	B cell leukemia/lymphoma 2	Mus musculus	172-177
22096572-11	2011	CONCLUSIONS/SIGNIFICANCE: These data suggest that FE activates a caspase-independent apoptotic pathway in MCF-7 cancer cells through activation of ROS-mediated MAP kinases and regulation of the Bcl-2 family protein-mediated mitochondrial pathway.	Iron	50-52	BCL2 apoptosis regulator	Homo sapiens	194-199
21401293-9	2011	In conclusion, the present results indicate a direct effect of iron on 1) secretion of growth factor IGF-I but not steroid hormone progesterone, 2) expression of markers of proliferation (cyclin B1), or 3) apoptosis (caspase-3) of porcine ovarian granulosa cells.	Iron	63-67	insulin like growth factor 1	Homo sapiens	101-106
21401293-9	2011	In conclusion, the present results indicate a direct effect of iron on 1) secretion of growth factor IGF-I but not steroid hormone progesterone, 2) expression of markers of proliferation (cyclin B1), or 3) apoptosis (caspase-3) of porcine ovarian granulosa cells.	Iron	63-67	caspase 3	Homo sapiens	217-226
22096572-6	2011	FE induces mitochondrial membrane permeabilization (MMP) through loss of mitochondrial membrane potential (DeltaPsim) and regulation of the expression of Bcl-2 family members.	Iron	0-2	BCL2 apoptosis regulator	Homo sapiens	154-159
22096572-9	2011	Additionally, FE was found to induce phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK) 1/2, and apoptosis was found to be attenuated by inhibition of JNK.	Iron	14-16	mitogen-activated protein kinase 8	Homo sapiens	56-79
22096572-9	2011	Additionally, FE was found to induce phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK) 1/2, and apoptosis was found to be attenuated by inhibition of JNK.	Iron	14-16	mitogen-activated protein kinase 8	Homo sapiens	81-84
22096572-9	2011	Additionally, FE was found to induce phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK) 1/2, and apoptosis was found to be attenuated by inhibition of JNK.	Iron	14-16	mitogen-activated protein kinase 1	Homo sapiens	87-90
22096572-9	2011	Additionally, FE was found to induce phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK) 1/2, and apoptosis was found to be attenuated by inhibition of JNK.	Iron	14-16	mitogen-activated protein kinase 3	Homo sapiens	96-143
22096572-9	2011	Additionally, FE was found to induce phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK) 1/2, and apoptosis was found to be attenuated by inhibition of JNK.	Iron	14-16	mitogen-activated protein kinase 8	Homo sapiens	203-206
22096572-10	2011	Furthermore, FE-mediated apoptosis was found to involve the generation of reactive oxygen species (ROS), which are responsible for the decrease of DeltaPsim and phosphorylation of JNK, p38, and ERK1/2 kinases.	Iron	13-15	mitogen-activated protein kinase 8	Homo sapiens	180-183
22096572-10	2011	Furthermore, FE-mediated apoptosis was found to involve the generation of reactive oxygen species (ROS), which are responsible for the decrease of DeltaPsim and phosphorylation of JNK, p38, and ERK1/2 kinases.	Iron	13-15	mitogen-activated protein kinase 1	Homo sapiens	185-188
22046282-3	2011	Activated gadd153 can generate oxidative damage and reactive oxygen species (ROS), increase beta-amyloid (Abeta) levels, disturb iron homeostasis and induce inflammation as well as cell death, which are all pathological hallmarks of AD.	Iron	129-133	DNA damage inducible transcript 3	Homo sapiens	10-17
22096572-10	2011	Furthermore, FE-mediated apoptosis was found to involve the generation of reactive oxygen species (ROS), which are responsible for the decrease of DeltaPsim and phosphorylation of JNK, p38, and ERK1/2 kinases.	Iron	13-15	mitogen-activated protein kinase 3	Homo sapiens	194-200
22132121-0	2011	Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases.	Iron	93-97	lactoperoxidase	Homo sapiens	48-63
22132121-7	2011	Lactoperoxidase heme destruction was associated with protein aggregation, free iron release, and formation of a number of fluorescent heme degradation products.	Iron	79-83	lactoperoxidase	Homo sapiens	0-15
22046282-9	2011	Additionally, 27-OHC-induced tau phosphorylation, ROS generation, TNF-alpha activation, and iron and apoptosis-regulatory protein levels alteration were also markedly reduced by siRNA to gadd153.	Iron	92-96	DNA damage inducible transcript 3	Homo sapiens	187-194
21546885-7	2011	The understanding of iron and the imbalance of redox homeostasis within the vasculature is integral in hypertension and progression of metabolic dysregulation that contributes to insulin resistance, endothelial dysfunction, and cardiovascular and kidney disease.	Iron	21-25	insulin	Homo sapiens	179-186
21957487-0	2011	Hepcidin is involved in iron regulation in the ischemic brain.	Iron	24-28	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
21957487-6	2011	The expression level of the iron-export protein ferroportin1 (FPN1) significantly decreased, while the expression of transferrin receptor 1 (TfR1) was increased.	Iron	28-32	solute carrier family 40 member 1	Rattus norvegicus	48-60
21957487-6	2011	The expression level of the iron-export protein ferroportin1 (FPN1) significantly decreased, while the expression of transferrin receptor 1 (TfR1) was increased.	Iron	28-32	solute carrier family 40 member 1	Rattus norvegicus	62-66
21957487-10	2011	The results indicate that hepcidin is an important contributor to iron overload in cerebral ischemia.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	26-34
21887333-12	2011	We propose a model in which aconitase functions as a licensing factor in ERK-dependent proliferation and differentiation, thereby providing a regulatory input for iron in EPO-dependent erythropoiesis.	Iron	163-167	mitogen-activated protein kinase 1	Mus musculus	73-76
21801495-1	2011	Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-kappaB1(p50).	Iron	0-4	B cell leukemia/lymphoma 3	Mus musculus	126-130
21801495-1	2011	Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-kappaB1(p50).	Iron	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-145
21801495-1	2011	Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-kappaB1(p50).	Iron	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-149
21179240-3	2010	METHODS: The proton-induced X-ray emission (PIXE) method was used to quantify iron in rd10 mice 2, 3, and 4 weeks after birth.	Iron	78-82	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	86-90
21335214-4	2011	This approach is allowed by the use of recombinant human erythropoietin in association with erythropoiesis-inducing factors such as iron and folic acid.	Iron	132-136	erythropoietin	Homo sapiens	57-71
20863724-7	2010	We found that in human liver, not only HAMP, but also SMAD7 and Id1 mRNA significantly correlate with the extent of hepatic iron burden.	Iron	124-128	SMAD family member 7	Homo sapiens	54-59
21434307-7	2011	There is a positive correlation between serum iron and insulin resistance index and blood glucose.	Iron	46-50	insulin	Homo sapiens	55-62
20956517-8	2010	Low Smf2 levels were not observed in AFT1/YFH1 double mutants, indicating that high iron levels could be responsible for the Smf2 decline.	Iron	84-88	divalent metal ion transporter SMF2	Saccharomyces cerevisiae S288C	4-8
20956517-8	2010	Low Smf2 levels were not observed in AFT1/YFH1 double mutants, indicating that high iron levels could be responsible for the Smf2 decline.	Iron	84-88	divalent metal ion transporter SMF2	Saccharomyces cerevisiae S288C	125-129
20844238-8	2010	Thus, in HO-1(-/-) mammals, the reduced function and viability of erythrophagocytosing macrophages are the main causes of tissue damage and iron redistribution.	Iron	140-144	heme oxygenase 1	Mus musculus	9-13
20843714-4	2010	Fifty Brazilian patients with primary iron overload (transferrin saturation&gt;50% in females and 60% in males) were selected.	Iron	38-42	transferrin	Homo sapiens	53-64
20721391-11	2010	When the ACCN ligand was used instead of the AIBN ligand, in compounds 3 and 4, only one crystallographically unique Fe(II) centre was observed in an otherwise similar framework.	Iron	117-119	acid sensing ion channel subunit 2	Homo sapiens	9-13
21179240-8	2010	RESULTS: PIXE analysis demonstrated an age-dependent iron accumulation in the photoreceptors of rd10 mice.	Iron	53-57	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	96-100
21179240-11	2010	CONCLUSIONS: Our results suggest that iron accumulation in the retinas of rd10 mutant mice is associated with photoreceptor degeneration.	Iron	38-42	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	74-78
20889785-1	2010	Grx3 and Grx4 are two monothiol glutaredoxins of Saccharomyces cerevisiae that have previously been characterized as regulators of Aft1 localization and therefore of iron homeostasis.	Iron	166-170	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	9-13
20737261-1	2010	Hepcidin is a key regulator responsible for systemic iron homeostasis.	Iron	53-57	hepcidin	Macaca fascicularis	0-8
20667716-3	2010	At 800 degrees C, the impregnation of Fe (III), Ni (II), Co (II) or Ru (IV) led to almost complete conversion of the solid biomass into gas/liquid products, producing an extremely low char yield (&lt;1-4 wt.%), and a very high yield of combustible gas (from 51.7 wt.% for Fe to 84 wt.% for Ru).	Iron	38-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-70
20039148-1	2010	The present study was aimed to determine the effect of iron supplementation on levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with iron deficiency anemia (IDA).	Iron	55-59	vascular cell adhesion molecule 1	Homo sapiens	153-186
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	Iron	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20850986-9	2010	IFN-gamma positively correlated with indicators of iron status, body, and thymus weights (r=0.238-0.472; p&lt;0.05).	Iron	51-55	interferon gamma	Mus musculus	0-9
21110186-0	2010	Assessment of in-plant particulate matter and its toxic metals contents of sponge iron industry in Goa, India.	Iron	82-86	tripartite motif containing 47	Homo sapiens	99-102
20704547-4	2010	A link between HO-1 and iron homeostasis has been demonstrated in HO-1 knockout mice, which develop major hemosiderosis in solid organs such as liver and kidney.	Iron	24-28	heme oxygenase 1	Mus musculus	15-19
20704547-4	2010	A link between HO-1 and iron homeostasis has been demonstrated in HO-1 knockout mice, which develop major hemosiderosis in solid organs such as liver and kidney.	Iron	24-28	heme oxygenase 1	Mus musculus	66-70
20704547-8	2010	In particular, cell-specific functions of HO-1 in liver tissue macrophages (Kupffer cells) might be of major significance, because these cells play a key role in iron recycling during erythrophagocytosis and also in the control of hepatic and systemic inflammatory responses.	Iron	162-166	heme oxygenase 1	Mus musculus	42-46
20704547-9	2010	This review discusses the current knowledge on interactions of HO-1 with iron metabolism in the context of systemic as well as hepatic inflammatory disorders.	Iron	73-77	heme oxygenase 1	Mus musculus	63-67
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	53-55	surfactant associated 3	Homo sapiens	34-37
20713458-9	2010	Patients with iron-refractory iron-deficiency anemia with a mutation in the TMPRSS6 gene were found to have lower levels of circulating hemojuvelin than those in healthy patients.	Iron	14-18	transmembrane serine protease 6	Homo sapiens	76-83
21235502-5	2010	Some dithiol glutaredoxins such as human Grx2 form dimers bridged by one iron-sulfur cluster, which acts as a sensor of oxidative stress, therefore regulating the activity of the glutaredoxin.	Iron	73-77	glutaredoxin 2	Homo sapiens	41-45
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	100-104	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	138-142
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	100-104	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	272-276
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	138-142
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	272-276
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	138-142
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	272-276
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	138-142
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	272-276
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	53-55	surfactant associated 3	Homo sapiens	77-80
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	53-55	surfactant associated 3	Homo sapiens	77-80
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	74-76	surfactant associated 3	Homo sapiens	34-37
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	74-76	surfactant associated 3	Homo sapiens	77-80
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	74-76	surfactant associated 3	Homo sapiens	77-80
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	74-76	surfactant associated 3	Homo sapiens	34-37
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	74-76	surfactant associated 3	Homo sapiens	77-80
21062066-2	2010	The reaction of Ph(2)PC(6)H(4)C(O)SPh and sources of Fe(0) generates both Fe(SPh)(Ph(2)PC(6)H(4)CO)(CO)(3) (1) and the diferrous diacyl Fe(2)(SPh)(2)(CO)(3)(Ph(2)PC(6)H(4)CO)(2), which carbonylates to give 1.	Iron	74-76	surfactant associated 3	Homo sapiens	77-80
21062066-4	2010	Complex 1 reacts with cyanide to give Et(4)N[Fe(SPh)(Ph(2)PC(6)H(4)CO)(CN)(CO)(2)] (Et(4)N[2]).	Iron	45-47	surfactant associated 3	Homo sapiens	48-51
20673928-7	2010	Normalization of the iron stores (ferritin and transferrin) improved the glucose tolerance status of 4 patients with IGT (to normal glucose tolerance), whereas 2 of those with IGT progressed to T2DM.	Iron	21-25	transferrin	Homo sapiens	47-58
20801540-2	2010	Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facilitates cellular iron export and iron binding to transferrin.	Iron	114-118	transferrin	Homo sapiens	130-141
21416972-0	2010	[Regulation mechanisms of bone morphogenetic protein-6 on iron metabolism].	Iron	58-62	bone morphogenetic protein 6	Homo sapiens	26-54
20882247-1	2010	We report the synthesis of highly luminescent, water soluble quantum clusters (QCs) of gold, which are stabilized by an iron binding transferrin family protein, lactoferrin (Lf).	Iron	120-124	transferrin	Homo sapiens	133-144
20626630-10	2010	However, pioglitazone inhibited iron-induced alpha-synuclein aggregation, elevations in interleukin-1beta and interleukin-6 mRNA levels as well as increases in oxygenase-1, cyclo-oxygenase II, nitric oxide synthase and ED-1 protein levels, an indicator of activated microglia.	Iron	32-36	interleukin 1 beta	Rattus norvegicus	88-105
20626630-10	2010	However, pioglitazone inhibited iron-induced alpha-synuclein aggregation, elevations in interleukin-1beta and interleukin-6 mRNA levels as well as increases in oxygenase-1, cyclo-oxygenase II, nitric oxide synthase and ED-1 protein levels, an indicator of activated microglia.	Iron	32-36	interleukin 6	Rattus norvegicus	110-123
21510013-8	2010	Equal loading of Fe3+ and Cr3+ into apo-transferrin was achieved when chromium was at a level more than 5 times in excess of iron.	Iron	125-129	transferrin	Homo sapiens	40-51
20688958-2	2010	Ferroportin1 (FPN1) expression can be transcriptionally regulated by iron as well as other transition metals.	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-12
20929261-1	2010	The mammea-type coumarin mammea E/BB (1) was found to inhibit both hypoxia-induced and iron chelator-induced hypoxia-inducible factor-1 (HIF-1) activation in human breast tumor T47D cells with IC(50) values of 0.96 and 0.89 muM, respectively.	Iron	87-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-135
20929261-1	2010	The mammea-type coumarin mammea E/BB (1) was found to inhibit both hypoxia-induced and iron chelator-induced hypoxia-inducible factor-1 (HIF-1) activation in human breast tumor T47D cells with IC(50) values of 0.96 and 0.89 muM, respectively.	Iron	87-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-142
20929261-1	2010	The mammea-type coumarin mammea E/BB (1) was found to inhibit both hypoxia-induced and iron chelator-induced hypoxia-inducible factor-1 (HIF-1) activation in human breast tumor T47D cells with IC(50) values of 0.96 and 0.89 muM, respectively.	Iron	87-91	latexin	Homo sapiens	224-227
20688958-2	2010	Ferroportin1 (FPN1) expression can be transcriptionally regulated by iron as well as other transition metals.	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	14-18
22778810-3	2010	The identified lead, HLA20A, exhibits little affinity for metal (Fe, Cu, and Zn) ions but can be activated following inhibition of AChE to liberate an active chelator, HLA20.	Iron	65-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
22778810-6	2010	HLA20A showed little iron-binding capacity and activity against iron-induced lipid peroxidation (LPO) at concentrations of 1-50 muM, while HLA20 exhibited high potency in iron-binding and in inhibiting iron-induced LPO.	Iron	64-68	latexin	Homo sapiens	128-131
22778810-6	2010	HLA20A showed little iron-binding capacity and activity against iron-induced lipid peroxidation (LPO) at concentrations of 1-50 muM, while HLA20 exhibited high potency in iron-binding and in inhibiting iron-induced LPO.	Iron	64-68	latexin	Homo sapiens	128-131
22778810-6	2010	HLA20A showed little iron-binding capacity and activity against iron-induced lipid peroxidation (LPO) at concentrations of 1-50 muM, while HLA20 exhibited high potency in iron-binding and in inhibiting iron-induced LPO.	Iron	64-68	latexin	Homo sapiens	128-131
20738258-0	2010	Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.	Iron	107-111	mitogen-activated protein kinase 1	Mus musculus	26-29
20214491-3	2010	IRP1 and IRP2 are similar (but not identical) proteins with partially overlapping and complementary functions, and control cell iron metabolism by binding to IREs (i.e., conserved RNA stem-loops located in the untranslated regions of a dozen mRNAs directly or indirectly related to iron metabolism).	Iron	128-132	iron responsive element binding protein 2	Homo sapiens	9-13
20214491-3	2010	IRP1 and IRP2 are similar (but not identical) proteins with partially overlapping and complementary functions, and control cell iron metabolism by binding to IREs (i.e., conserved RNA stem-loops located in the untranslated regions of a dozen mRNAs directly or indirectly related to iron metabolism).	Iron	282-286	iron responsive element binding protein 2	Homo sapiens	9-13
20738258-6	2010	With respect to iron uptake, we found that ERK inhibitor treatment led to an increase in both haem-bound and total iron.	Iron	16-20	mitogen-activated protein kinase 1	Mus musculus	43-46
20738258-6	2010	With respect to iron uptake, we found that ERK inhibitor treatment led to an increase in both haem-bound and total iron.	Iron	115-119	mitogen-activated protein kinase 1	Mus musculus	43-46
20799927-1	2010	The periplasmic FbpA (ferric-binding protein A) from Haemophilus influenzae plays a critical role in acquiring iron from host transferrin, shuttling iron from the outer-membrane receptor complex to the inner-membrane transport complex responsible for transporting iron into the cytoplasm.	Iron	111-115	transferrin	Homo sapiens	126-137
20738258-10	2010	These results provide a novel link between MAPK signalling and the regulation of haem biosynthesis and iron uptake in erythroid cells.	Iron	103-107	mitogen-activated protein kinase 1	Mus musculus	43-47
20799927-2	2010	In the present study, we report on the properties of a series of site-directed mutants of two adjacent tyrosine residues involved in iron co-ordination, and demonstrate that, in contrast with mutation of equivalent residues in the N-lobe of human transferrin, the mutant FbpAs retain significant iron-binding affinity regardless of the nature of the replacement amino acid.	Iron	133-137	transferrin	Homo sapiens	247-258
21188175-3	2010	Those of Cu and Fe are redox active and bind to Abeta in vitro.	Iron	16-18	amyloid beta precursor protein	Homo sapiens	48-53
20873749-3	2010	Here we provide in vitro evidence that human frataxin binds to a Nfs1, Isd11, and Isu2 complex to generate the four-component core machinery for Fe-S cluster biosynthesis.	Iron	145-149	LYR motif containing 4	Homo sapiens	71-76
21054916-7	2010	Mutations in hepcidin or its upstream regulators (HFE, TFR2, HFE2 and BMP6) lead to reduced or absent hepcidin expression and a concomitant increase in iron absorption.	Iron	152-156	bone morphogenetic protein 6	Homo sapiens	70-74
20873749-3	2010	Here we provide in vitro evidence that human frataxin binds to a Nfs1, Isd11, and Isu2 complex to generate the four-component core machinery for Fe-S cluster biosynthesis.	Iron	145-149	iron-sulfur cluster assembly enzyme	Homo sapiens	82-86
20679134-1	2010	Heme oxygenase 1 (HO-1) uses molecular oxygen and electrons from NADPH cytochrome P450 reductase to convert heme to CO, ferrous iron, and biliverdin (BV).	Iron	128-132	cytochrome p450 oxidoreductase	Homo sapiens	65-96
21084824-3	2010	The transferrin saturation rate showed marked elevation together with serum iron.	Iron	76-80	transferrin	Homo sapiens	4-15
21084824-4	2010	This fact indicates that the release of non-transferrin bound iron (NTBI) occurs and then, NTBI binds with transferrin immediately thereafter.	Iron	62-66	transferrin	Homo sapiens	44-55
21084824-4	2010	This fact indicates that the release of non-transferrin bound iron (NTBI) occurs and then, NTBI binds with transferrin immediately thereafter.	Iron	62-66	transferrin	Homo sapiens	107-118
20188363-7	2010	Iron overload activates NF-kappaB in macrophages.	Iron	0-4	nuclear factor kappa B subunit 1	Homo sapiens	24-33
20942746-1	2010	IMPORTANCE OF THE FIELD: Increased localization of Zn, Fe, Cu and Al within the senile plaques (SP) exacerbates amyloid beta (Abeta)-mediated oxidative damage, and acts as catalyst for Abeta aggregation in Alzheimer"s disease (AD).	Iron	55-57	amyloid beta precursor protein	Homo sapiens	112-124
20942746-1	2010	IMPORTANCE OF THE FIELD: Increased localization of Zn, Fe, Cu and Al within the senile plaques (SP) exacerbates amyloid beta (Abeta)-mediated oxidative damage, and acts as catalyst for Abeta aggregation in Alzheimer"s disease (AD).	Iron	55-57	amyloid beta precursor protein	Homo sapiens	126-131
20945995-7	2010	CONCLUSIONS: These results suggest that IFN therapy may increase the risk of complications of DFP-based iron chelation therapy in patients with thalassemia.	Iron	104-108	interferon alpha 1	Homo sapiens	40-43
20711621-0	2010	Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin.	Iron	83-87	transferrin	Homo sapiens	121-132
20711621-1	2010	His349 in human transferrin (hTF) is a residue critical to transferrin receptor (TFR)-stimulated iron release from the C-lobe.	Iron	97-101	transferrin	Homo sapiens	16-27
20866083-0	2010	Iron catalyzed competitive olefin oxidation and ipso-hydroxylation of benzoic acids: further evidence for an Fe(V) O oxidant.	Iron	0-4	FEV transcription factor, ETS family member	Homo sapiens	109-114
20935638-0	2010	Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila.	Iron	65-69	Transferrin 2	Drosophila melanogaster	47-64
20935638-3	2010	Melanotransferrin (MTf) is a phylogenetically conserved, iron-binding epithelial protein.	Iron	57-61	Transferrin 2	Drosophila melanogaster	0-17
20935638-3	2010	Melanotransferrin (MTf) is a phylogenetically conserved, iron-binding epithelial protein.	Iron	57-61	Transferrin 2	Drosophila melanogaster	19-22
20935638-6	2010	Similarly to its human homologue, Drosophila MTf is a lipid-modified, iron-binding protein attached to epithelial cell membranes, and is a component of the septate junctions that form the paracellular permeability barrier in epithelial tissues.	Iron	70-74	Transferrin 2	Drosophila melanogaster	45-48
20935638-7	2010	We demonstrate that septate junction assembly during epithelial maturation relies on endocytosis and apicolateral recycling of iron-bound MTf.	Iron	127-131	Transferrin 2	Drosophila melanogaster	138-141
20447458-1	2010	Transferrin is an essential ingredient used in cell culture media due to its crucial role in regulating cellular iron uptake, transport, and utilization.	Iron	113-117	transferrin	Homo sapiens	0-11
20447458-6	2010	The rice-derived recombinant human transferrin was shown to be not only structurally similar to the native human transferrin, but also functionally the same as native transferrin in terms of reversible iron binding and promoting cell growth and productivity.	Iron	202-206	transferrin	Homo sapiens	35-46
20686114-2	2010	Mutations in the PLA2G6 gene encoding this enzyme occur in patients with idiopathic neurodegeneration plus brain iron accumulation and dystonia-parkinsonism without iron accumulation, whereas mice lacking PLA2G6 show neurological dysfunction and neuropathology after 13 months.	Iron	113-117	phospholipase A2 group VI	Homo sapiens	17-23
20727382-1	2010	Previously, we demonstrated that IL-1beta was able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis.	Iron	63-67	interleukin 1 beta	Homo sapiens	33-41
20702403-0	2010	Role of H-1 and H-2 subunits of soybean seed ferritin in oxidative deposition of iron in protein.	Iron	81-85	homeobox protein SBH1	Glycine max	8-19
20981023-2	2010	Independent reports have linked frataxin to iron-sulphur cluster assembly through interactions with the two central components of this machinery: desulphurase Nfs1/IscS and the scaffold protein Isu/IscU.	Iron	44-48	iron-sulfur cluster assembly enzyme	Homo sapiens	198-202
20800516-2	2010	Impaired SOD2 activity in murine hematopoietic cells affects erythroid development, resulting in anemia characterized by intra-mitochondrial iron deposition, reticulocytosis and shortened red cell life span.	Iron	141-145	superoxide dismutase 2, mitochondrial	Mus musculus	9-13
20682781-0	2010	ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin.	Iron	70-74	transferrin	Homo sapiens	80-91
20682781-2	2010	Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediates the uptake of non-transferrin-bound iron, a form of iron that appears in the plasma during pathologic iron overload.	Iron	148-152	transferrin	Homo sapiens	130-141
20682781-2	2010	Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediates the uptake of non-transferrin-bound iron, a form of iron that appears in the plasma during pathologic iron overload.	Iron	164-168	transferrin	Homo sapiens	130-141
20702403-5	2010	These findings support the idea that the H-1 and H-2 subunits play different roles in iron mineralization in protein.	Iron	86-90	homeobox protein SBH1	Glycine max	41-52
20682781-2	2010	Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediates the uptake of non-transferrin-bound iron, a form of iron that appears in the plasma during pathologic iron overload.	Iron	164-168	transferrin	Homo sapiens	130-141
20682781-3	2010	In this study we investigated the role of ZIP14 in the cellular assimilation of iron from transferrin, the circulating plasma protein that normally delivers iron to cells by receptor-mediated endocytosis.	Iron	80-84	transferrin	Homo sapiens	90-101
20674685-4	2010	The aggregation states of Abeta in the presence of iron and copper, as well as their effects on synaptic viability and signaling were investigated in this work.	Iron	51-55	amyloid beta precursor protein	Homo sapiens	26-31
20682781-3	2010	In this study we investigated the role of ZIP14 in the cellular assimilation of iron from transferrin, the circulating plasma protein that normally delivers iron to cells by receptor-mediated endocytosis.	Iron	157-161	transferrin	Homo sapiens	90-101
20682781-5	2010	We found that overexpression of ZIP14 in HEK 293T cells increased the assimilation of iron from transferrin without increasing levels of transferrin receptor 1 or the uptake of transferrin.	Iron	86-90	transferrin	Homo sapiens	96-107
20682781-8	2010	HepG2 cells in which endogenous ZIP14 was suppressed by siRNA assimilated 50% less iron from transferrin compared with controls.	Iron	83-87	transferrin	Homo sapiens	93-104
20682781-10	2010	We also found that ZIP14 can mediate the transport of iron at pH 6.5, the pH at which iron dissociates from transferrin within the endosome.	Iron	54-58	transferrin	Homo sapiens	108-119
20682781-11	2010	These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism.	Iron	88-92	transferrin	Homo sapiens	98-109
20682781-11	2010	These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism.	Iron	164-168	transferrin	Homo sapiens	98-109
20674685-6	2010	However, in the presence of Abeta/iron (10 and 50 muM), plasma membrane integrity was disrupted to a greater extent than when generated by either iron or Abeta alone, indicating that the membrane constitutes the first target of synaptic injury.	Iron	34-38	latexin	Homo sapiens	50-53
20674685-6	2010	However, in the presence of Abeta/iron (10 and 50 muM), plasma membrane integrity was disrupted to a greater extent than when generated by either iron or Abeta alone, indicating that the membrane constitutes the first target of synaptic injury.	Iron	146-150	amyloid beta precursor protein	Homo sapiens	28-33
20938027-1	2010	BACKGROUND: PLA2G6 is the causative gene for infantile neuroaxonal dystrophy, neurodegeneration associated with brain iron accumulation, and Karak syndrome.	Iron	118-122	phospholipase A2 group VI	Homo sapiens	12-18
20938027-11	2010	CONCLUSIONS: Although the clinical presentation of PLA2G6-associated neurodegeneration was reported to be homogeneous, our findings suggest patients with PLA2G6 mutation could show heterogeneous phenotype such as dystonia-parkinsonism, dementia, frontotemporal atrophy/hypoperfusion, with or without brain iron accumulation.	Iron	306-310	phospholipase A2 group VI	Homo sapiens	154-160
20938027-11	2010	CONCLUSIONS: Although the clinical presentation of PLA2G6-associated neurodegeneration was reported to be homogeneous, our findings suggest patients with PLA2G6 mutation could show heterogeneous phenotype such as dystonia-parkinsonism, dementia, frontotemporal atrophy/hypoperfusion, with or without brain iron accumulation.	Iron	306-310	phospholipase A2 group VI	Homo sapiens	51-57
20558735-2	2010	Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical IREs controls iron-dependent translation of the ferritin subunits.	Iron	35-39	iron responsive element binding protein 2	Homo sapiens	70-74
20558735-1	2010	Iron influx increases the translation of the Alzheimer amyloid precursor protein (APP) via an iron-responsive element (IRE) RNA stem loop in its 5"-untranslated region.	Iron	0-4	amyloid beta precursor protein	Homo sapiens	55-80
20558735-2	2010	Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical IREs controls iron-dependent translation of the ferritin subunits.	Iron	105-109	iron responsive element binding protein 2	Homo sapiens	70-74
20558735-1	2010	Iron influx increases the translation of the Alzheimer amyloid precursor protein (APP) via an iron-responsive element (IRE) RNA stem loop in its 5"-untranslated region.	Iron	94-98	amyloid beta precursor protein	Homo sapiens	55-80
20678169-8	2010	In the pig, SERPINA14 is involved in iron transport to the fetus by binding to and stabilizing the iron-binding protein uteroferrin.	Iron	37-41	uterine milk protein	Ovis aries	12-21
20570646-2	2010	The nonacarbon chain streptocyanine 9Cl(NEt(2))(2) was found to be relatively stable in neutral buffered aqueous solutions, to be reduced at a significant rate by superoxide, and addition of iron-dependent superoxide dismutase (Fe-SOD) prevented its bleaching, thus constituting a good candidate as a possible superoxide indicator in a spectrophotometric SOD assay.	Iron	191-195	superoxide dismutase 1	Homo sapiens	206-226
20570646-2	2010	The nonacarbon chain streptocyanine 9Cl(NEt(2))(2) was found to be relatively stable in neutral buffered aqueous solutions, to be reduced at a significant rate by superoxide, and addition of iron-dependent superoxide dismutase (Fe-SOD) prevented its bleaching, thus constituting a good candidate as a possible superoxide indicator in a spectrophotometric SOD assay.	Iron	191-195	superoxide dismutase 1	Homo sapiens	231-234
20570646-2	2010	The nonacarbon chain streptocyanine 9Cl(NEt(2))(2) was found to be relatively stable in neutral buffered aqueous solutions, to be reduced at a significant rate by superoxide, and addition of iron-dependent superoxide dismutase (Fe-SOD) prevented its bleaching, thus constituting a good candidate as a possible superoxide indicator in a spectrophotometric SOD assay.	Iron	191-195	superoxide dismutase 1	Homo sapiens	355-358
20554970-5	2010	Iron-overloaded mice had increased reactive oxygen species and elevated serum tumor necrosis factor-alpha and interleukin-6 concentrations that correlated with severity of iron overload.	Iron	0-4	tumor necrosis factor	Mus musculus	78-105
20554970-5	2010	Iron-overloaded mice had increased reactive oxygen species and elevated serum tumor necrosis factor-alpha and interleukin-6 concentrations that correlated with severity of iron overload.	Iron	0-4	interleukin 6	Mus musculus	110-123
20554970-5	2010	Iron-overloaded mice had increased reactive oxygen species and elevated serum tumor necrosis factor-alpha and interleukin-6 concentrations that correlated with severity of iron overload.	Iron	172-176	interleukin 6	Mus musculus	110-123
20709802-0	2010	Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARalpha dependent mechanism.	Iron	65-69	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
20709802-1	2010	Protective effects of adiponectin (APN; an adipocytokine) were shown against various oxidative challenges; however, its therapeutic implications and the mechanisms underlying hepatic iron overload remain unclear.	Iron	183-187	adiponectin, C1Q and collagen domain containing	Homo sapiens	22-33
20709802-1	2010	Protective effects of adiponectin (APN; an adipocytokine) were shown against various oxidative challenges; however, its therapeutic implications and the mechanisms underlying hepatic iron overload remain unclear.	Iron	183-187	adiponectin, C1Q and collagen domain containing	Homo sapiens	35-38
20709802-2	2010	Herein, we show that the deleterious effects of iron dextran on liver function and iron deposition were significantly reversed by adiponectin gene therapy, which was accompanied by AMP-activated protein kinase (AMPK) phosphorylation and heme oxygenase (HO)-1 induction.	Iron	48-52	adiponectin, C1Q and collagen domain containing	Homo sapiens	130-141
20709802-5	2010	Interestingly, overexpression of HO-1 in hepatocytes mimicked the protective effect of APN in attenuating iron-mediated injury, whereas it was abolished by SnPP and small interfering HO-1.	Iron	106-110	adiponectin, C1Q and collagen domain containing	Homo sapiens	87-90
20709802-7	2010	Herein, we demonstrate a novel functional PPRE in the promoter regions of HO-1, and APN-mediated HO-1 induction elicited an antiapoptotic effect and a decrease in iron deposition in hepatocytes subjected to iron challenge.	Iron	163-167	adiponectin, C1Q and collagen domain containing	Homo sapiens	84-87
20709802-7	2010	Herein, we demonstrate a novel functional PPRE in the promoter regions of HO-1, and APN-mediated HO-1 induction elicited an antiapoptotic effect and a decrease in iron deposition in hepatocytes subjected to iron challenge.	Iron	207-211	adiponectin, C1Q and collagen domain containing	Homo sapiens	84-87
20678169-8	2010	In the pig, SERPINA14 is involved in iron transport to the fetus by binding to and stabilizing the iron-binding protein uteroferrin.	Iron	99-103	uterine milk protein	Ovis aries	12-21
20704529-0	2010	Automated assay for non-transferrin-bound iron in serum samples.	Iron	42-46	transferrin	Homo sapiens	24-35
20704529-1	2010	BACKGROUND: Non-transferrin-bound iron (NTBI) is a powerful promoter of free radical damage and highly toxic to biological systems, resulting in oxidative damage to proteins, lipids and DNA.	Iron	34-38	transferrin	Homo sapiens	16-27
20796026-4	2010	An unbiased motif search of the transferrin promoter region showed that CP2 binds to the transferrin promoter, an iron-regulating protein, and regulates transferrin transcription.	Iron	114-118	transferrin	Homo sapiens	32-43
20692246-1	2010	OBJECTIVE: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity.	Iron	86-90	paraoxonase 1	Homo sapiens	173-177
20796026-4	2010	An unbiased motif search of the transferrin promoter region showed that CP2 binds to the transferrin promoter, an iron-regulating protein, and regulates transferrin transcription.	Iron	114-118	transferrin	Homo sapiens	89-100
20796026-4	2010	An unbiased motif search of the transferrin promoter region showed that CP2 binds to the transferrin promoter, an iron-regulating protein, and regulates transferrin transcription.	Iron	114-118	transferrin	Homo sapiens	89-100
20658468-8	2010	Hepatic expression of BMP6 was appropriately elevated in HFE-HH compared to controls (P = 0.02), likely related to iron overload.	Iron	115-119	bone morphogenetic protein 6	Homo sapiens	22-26
20511664-7	2010	Lipopolysaccharide-treated iron-deficient animals also showed lower liver alpha2m mRNA and reduced serum interleukin-6 and tumor necrosis factor-alpha, suggesting a more generalized effect of iron deficiency.	Iron	27-31	interleukin 6	Homo sapiens	105-150
20511664-8	2010	Similarly, RAW 264.7 cells treated with iron chelators and then stimulated with lipopolysaccharide showed lower IL-6 mRNA than cells treated with lipopolysaccharide alone.	Iron	40-44	interleukin 6	Mus musculus	112-116
20511664-9	2010	Huh7 cells treated with an iron chelator showed a blunted hepcidin response to interleukin-6, suggesting that the response of hepatic parenchymal cells to inflammatory cytokines may also be iron-dependent.	Iron	27-31	interleukin 6	Homo sapiens	79-92
20511664-9	2010	Huh7 cells treated with an iron chelator showed a blunted hepcidin response to interleukin-6, suggesting that the response of hepatic parenchymal cells to inflammatory cytokines may also be iron-dependent.	Iron	190-194	interleukin 6	Homo sapiens	79-92
20802492-0	2010	Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.	Iron	47-51	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	0-5
20631677-7	2010	Taken together, our results show that erythropoietin not only exerts a powerful inhibitory action on the expression of hepcidin, thus permitting the release of iron from reticuloendothelial macrophages and intestinal enterocytes, but also acts directly on enterocytes to increase iron absorption.	Iron	160-164	erythropoietin	Homo sapiens	38-52
20631677-7	2010	Taken together, our results show that erythropoietin not only exerts a powerful inhibitory action on the expression of hepcidin, thus permitting the release of iron from reticuloendothelial macrophages and intestinal enterocytes, but also acts directly on enterocytes to increase iron absorption.	Iron	280-284	erythropoietin	Homo sapiens	38-52
21462111-3	2010	The most likely explanation is the appearance of non-transferrin-bound iron (NTBI) in the plasma.	Iron	71-75	transferrin	Homo sapiens	53-64
21462111-4	2010	NTBI forms when the rate of iron influx into the plasma exceeds the rate of iron binding to transferrin.	Iron	76-80	transferrin	Homo sapiens	92-103
20866165-2	2010	Iron therapy is recommended, usually in combination with an erythropoiesis-stimulating agent (ESA), in many CKD patients with anemia and low iron levels to raise hemoglobin levels to a range of 10 to 12 grams per deciliter; iron deficiency is defined by a ferritin score less than 100 micrograms (mcg) per liter and transferrin saturation (TSAT) less than 20%.	Iron	0-4	transferrin	Homo sapiens	316-327
20631677-1	2010	Erythropoietin is produced by the kidney and stimulates erythropoiesis; however, in chronic renal disease its levels are reduced and patients develop anemia that is treatable with iron and recombinant hormone.	Iron	180-184	erythropoietin	Homo sapiens	0-14
20631677-2	2010	The mechanism by which erythropoietin improves iron homeostasis is still unclear, but it may involve suppression of the iron regulatory peptide hepcidin and/or a direct effect on intestinal iron absorption.	Iron	47-51	erythropoietin	Homo sapiens	23-37
20631677-2	2010	The mechanism by which erythropoietin improves iron homeostasis is still unclear, but it may involve suppression of the iron regulatory peptide hepcidin and/or a direct effect on intestinal iron absorption.	Iron	120-124	erythropoietin	Homo sapiens	23-37
20631677-2	2010	The mechanism by which erythropoietin improves iron homeostasis is still unclear, but it may involve suppression of the iron regulatory peptide hepcidin and/or a direct effect on intestinal iron absorption.	Iron	120-124	erythropoietin	Homo sapiens	23-37
20631677-6	2010	In Caco-2 cells, the addition of erythropoietin significantly increased the expression of apical divalent metal transporter 1 (DMT1) and basolateral ferroportin and, consequently, iron transport across the monolayer.	Iron	180-184	erythropoietin	Homo sapiens	33-47
20607173-1	2010	Accurate estimation of non-transferrin bound iron (NTBI) is an important tool in monitoring effects of chemotherapy and iron chelation therapy in various conditions of iron overload and transfusion related thalassemias.	Iron	45-49	transferrin	Homo sapiens	27-38
20607173-1	2010	Accurate estimation of non-transferrin bound iron (NTBI) is an important tool in monitoring effects of chemotherapy and iron chelation therapy in various conditions of iron overload and transfusion related thalassemias.	Iron	120-124	transferrin	Homo sapiens	27-38
20607173-1	2010	Accurate estimation of non-transferrin bound iron (NTBI) is an important tool in monitoring effects of chemotherapy and iron chelation therapy in various conditions of iron overload and transfusion related thalassemias.	Iron	120-124	transferrin	Homo sapiens	27-38
20802492-0	2010	Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.	Iron	47-51	cytokine induced apoptosis inhibitor 1	Homo sapiens	29-33
20546814-3	2010	Aberrant iron accumulation, mitochondrial dysfunction and impairment of protein degradation system, such as autophagy, have been implicated in the pathogenesis of Parkinson"s disease, among which, iron and mitochondrial dysfunction may enhance the enzyme activity of prolyl hydroxylase and cause the decrease of HIF-1 alpha.	Iron	197-201	hypoxia inducible factor 1 subunit alpha	Homo sapiens	312-323
20546814-5	2010	Considering the metabolic characteristics of HIF-1 alpha under the pathogenesis of Parkinson"s disease, we speculated that compounds that might stabilize HIF-1 alpha could prevent neuronal injury caused by excessive iron or mitochondrial injury under normoxic condition.	Iron	216-220	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-56
20546814-5	2010	Considering the metabolic characteristics of HIF-1 alpha under the pathogenesis of Parkinson"s disease, we speculated that compounds that might stabilize HIF-1 alpha could prevent neuronal injury caused by excessive iron or mitochondrial injury under normoxic condition.	Iron	216-220	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-165
20546814-6	2010	Deferoxamine is one of iron chelators that may accumulate HIF-1 alpha due to the decreased degradation of HIF-1 alpha via inhibition of prolyl hydroxylase activity.	Iron	23-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-69
20546814-6	2010	Deferoxamine is one of iron chelators that may accumulate HIF-1 alpha due to the decreased degradation of HIF-1 alpha via inhibition of prolyl hydroxylase activity.	Iron	23-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-117
20802492-2	2010	For biosynthesis of their Fe-S clusters, a dedicated cytosolic Fe-S protein assembly (CIA) machinery is required.	Iron	26-30	nuclear receptor coactivator 5	Homo sapiens	86-89
20802492-3	2010	Here, we identify the essential flavoprotein Tah18 as a previously unrecognized CIA component and show by cell biological, biochemical and spectroscopic approaches that the complex of Tah18 and the CIA protein Dre2 is part of an electron transfer chain functioning in an early step of cytosolic Fe-S protein biogenesis.	Iron	295-299	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	45-50
20802492-3	2010	Here, we identify the essential flavoprotein Tah18 as a previously unrecognized CIA component and show by cell biological, biochemical and spectroscopic approaches that the complex of Tah18 and the CIA protein Dre2 is part of an electron transfer chain functioning in an early step of cytosolic Fe-S protein biogenesis.	Iron	295-299	nuclear receptor coactivator 5	Homo sapiens	80-83
21071777-1	2010	In most genetic iron overload disorders the diagnosis can be rejected when transferrin saturation is low.	Iron	16-20	transferrin	Homo sapiens	75-86
20802492-3	2010	Here, we identify the essential flavoprotein Tah18 as a previously unrecognized CIA component and show by cell biological, biochemical and spectroscopic approaches that the complex of Tah18 and the CIA protein Dre2 is part of an electron transfer chain functioning in an early step of cytosolic Fe-S protein biogenesis.	Iron	295-299	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	184-189
21071777-2	2010	We describe a patient and her family with hyperferritinaemia and low transferrin saturation with iron accumulation in the central nervous system (CNS) and liver due to hereditary aceruloplasminaemia.	Iron	97-101	transferrin	Homo sapiens	69-80
20802492-3	2010	Here, we identify the essential flavoprotein Tah18 as a previously unrecognized CIA component and show by cell biological, biochemical and spectroscopic approaches that the complex of Tah18 and the CIA protein Dre2 is part of an electron transfer chain functioning in an early step of cytosolic Fe-S protein biogenesis.	Iron	295-299	nuclear receptor coactivator 5	Homo sapiens	198-201
20802492-3	2010	Here, we identify the essential flavoprotein Tah18 as a previously unrecognized CIA component and show by cell biological, biochemical and spectroscopic approaches that the complex of Tah18 and the CIA protein Dre2 is part of an electron transfer chain functioning in an early step of cytosolic Fe-S protein biogenesis.	Iron	295-299	cytokine induced apoptosis inhibitor 1	Homo sapiens	210-214
20802492-4	2010	Electrons are transferred from NADPH via the FAD- and FMN-containing Tah18 to the Fe-S clusters of Dre2.	Iron	82-86	NAPDH-dependent diflavin reductase	Saccharomyces cerevisiae S288C	69-74
20802492-4	2010	Electrons are transferred from NADPH via the FAD- and FMN-containing Tah18 to the Fe-S clusters of Dre2.	Iron	82-86	cytokine induced apoptosis inhibitor 1	Homo sapiens	99-103
20043217-4	2010	We observed that endocytosis of transferrin, which is involved in the delivery of iron to the cell, was increased after stress induced by heat shock or after incubation with inhibitors of Hsp90 function.	Iron	82-86	transferrin	Homo sapiens	32-43
20075851-6	2010	At baseline, the presence of iron depletion was high with 45% of the women having serum transferrin receptor (sTfR) &gt;28.1 nmol/l.	Iron	29-33	transferrin	Homo sapiens	88-99
20715813-8	2010	N(2)(prLH)(2) forms a 3:2 L:Fe complex with Fe(III) where log beta(230) = 60.46 +- 0.04 and log beta(110) = 20.39 +- 0.02.	Iron	28-30	prolactin releasing hormone	Homo sapiens	5-9
20095867-3	2010	An additional neuroprotective mechanism of iron chelators is associated with their ability to upregulate or stabilize the transcriptional activator, hypoxia-inducible factor-1alpha (HIF-1alpha).	Iron	43-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-180
20095867-3	2010	An additional neuroprotective mechanism of iron chelators is associated with their ability to upregulate or stabilize the transcriptional activator, hypoxia-inducible factor-1alpha (HIF-1alpha).	Iron	43-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	182-192
20095867-4	2010	HIF-1alpha stability within the cells is under the control of a class of iron-dependent and oxygen-sensor enzymes, HIF prolyl-4-hydroxylases (PHDs) that target HIF-1alpha for degradation.	Iron	73-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20095867-4	2010	HIF-1alpha stability within the cells is under the control of a class of iron-dependent and oxygen-sensor enzymes, HIF prolyl-4-hydroxylases (PHDs) that target HIF-1alpha for degradation.	Iron	73-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-170
20095867-6	2010	In accordance, a new potential therapeutic strategy for neurodegenerative diseases is explored, by which iron chelators would inhibit PHDs, target the HIF-1-signaling pathway and ultimately activate HIF-1-dependent neuroprotective genes.	Iron	105-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-156
20095867-6	2010	In accordance, a new potential therapeutic strategy for neurodegenerative diseases is explored, by which iron chelators would inhibit PHDs, target the HIF-1-signaling pathway and ultimately activate HIF-1-dependent neuroprotective genes.	Iron	105-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	199-204
20816093-0	2010	Intestinal ferritin H is required for an accurate control of iron absorption.	Iron	61-65	ferritin mitochondrial	Mus musculus	11-21
20816093-3	2010	Here, we found that mice with an intestinal ferritin H gene deletion show increased body iron stores and transferrin saturation.	Iron	89-93	ferritin mitochondrial	Mus musculus	44-54
20816093-4	2010	As expected for iron-loaded animals, the ferritin H-deleted mice showed induced liver hepcidin mRNA levels and reduced duodenal expression of DMT1 and DcytB mRNA.	Iron	16-20	ferritin mitochondrial	Mus musculus	41-51
20816093-6	2010	Our results demonstrate that hepcidin-mediated regulation alone is insufficient to restrict iron absorption and that intestinal ferritin H is also required to limit iron efflux from intestinal cells.	Iron	165-169	ferritin mitochondrial	Mus musculus	128-138
20615872-6	2010	We were able to definitely assign the bacteriostatic activity of transferrin to its iron-binding function: neither iron-saturated transferrin nor a recombinant transferrin mutant unable to bind iron could inhibit growth of B. anthracis.	Iron	84-88	transferrin	Homo sapiens	65-76
20711226-1	2010	Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH regulation, cell proliferation and viability.	Iron	328-332	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-62
20711226-1	2010	Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH regulation, cell proliferation and viability.	Iron	328-332	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-69
20716799-2	2010	Transferrin receptor (CD71) mediates the uptake of transferrin-iron complexes and is highly expressed on the surface of cells of the erythroid lineage.	Iron	63-67	transferrin	Homo sapiens	51-62
20886109-1	2010	BACKGROUND: Mutations in the PLA2G6 gene have been identified in autosomal recessive neurodegenerative diseases classified as infantile neuroaxonal dystrophy (INAD), neurodegeneration with brain iron accumulation (NBIA), and dystonia-parkinsonism.	Iron	195-199	phospholipase A2 group VI	Homo sapiens	29-35
20460119-8	2010	CONCLUSIONS: Ferroportin Q248H and low iron stores are both associated with lower circulating tumor necrosis factor-alpha, while only ferroportin Q248H is associated with lower circulating macrophage migration inhibitory factor.	Iron	39-43	tumor necrosis factor	Homo sapiens	94-121
19859668-1	2010	Human transferrin (Tf) very tightly binds two ferric ions to deliver iron to cells.	Iron	69-73	transferrin	Homo sapiens	6-17
19859668-1	2010	Human transferrin (Tf) very tightly binds two ferric ions to deliver iron to cells.	Iron	69-73	transferrin	Homo sapiens	19-21
20605052-7	2010	Our data indicate that Gal-3 is involved in the development of inflammation-associated anemia during African trypanosomiasis, possibly due to a disturbed iron metabolism that in turn may also lead to liver malfunction.	Iron	154-158	lectin, galactose binding, soluble 3	Mus musculus	23-28
20604729-1	2010	BACKGROUND: Erythropoietin therapy should be accompanied by an adequate iron supply in order to avoid functional iron deficiency (FID) related to enhanced erythropoiesis.	Iron	72-76	erythropoietin	Homo sapiens	12-26
20973112-4	2010	As quantified by SPIO-induced MRI signal extinction, intracellular iron-content was significantly higher in monoytes/macrophages incubated with CD11b-SPIO than with control-SPIO in vitro (p &lt; 0.05), suggesting an improved uptake of CD11b-SPIOs into monocytes.	Iron	67-71	integrin alpha M	Mus musculus	144-149
20973112-4	2010	As quantified by SPIO-induced MRI signal extinction, intracellular iron-content was significantly higher in monoytes/macrophages incubated with CD11b-SPIO than with control-SPIO in vitro (p &lt; 0.05), suggesting an improved uptake of CD11b-SPIOs into monocytes.	Iron	67-71	integrin alpha M	Mus musculus	235-240
20702562-0	2010	The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure.	Iron	4-8	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	18-31
20702562-4	2010	Following implantation of the mouse embryo, ferroportin 1 (Fpn1) is essential for the transport of iron from the mother to the fetus and is expressed in the visceral endoderm, yolk sac and placenta.	Iron	99-103	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	44-57
20702562-4	2010	Following implantation of the mouse embryo, ferroportin 1 (Fpn1) is essential for the transport of iron from the mother to the fetus and is expressed in the visceral endoderm, yolk sac and placenta.	Iron	99-103	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	59-63
20817949-6	2010	A minimalist scheme of the interaction of cyt c with hydrogen peroxide can be described by two steps: 1) interaction of hydrogen peroxide with heme iron forming the postulated ferryl intermediate, 2a) oxidation of another molecule of hydrogen peroxide and 2b) parallel oxidation of close amino acid residue(s) and/or heme.	Iron	148-152	cytochrome c, somatic	Homo sapiens	42-47
21072355-1	2010	A sample preparation strategy for the determination of the Fe-containing enzyme catalase (CAT) by Fe specific monitoring in human erythrocytes has been optimized.	Iron	59-61	catalase	Homo sapiens	80-88
20569990-6	2010	Using cyclic voltammetry and discontinuous metalloprotein spectroelectrochemistry (dSEC) in conjunction with the LFER, we report that the redox potential of titanium-transferrin is lower than -600 mV (lower than that of iron-transferrin) and is predicted to be ca.	Iron	220-224	transferrin	Homo sapiens	166-177
20569990-9	2010	This observation is discussed in the context of current hypotheses concerning the role of reduction in transferrin mediated iron transport.	Iron	124-128	transferrin	Homo sapiens	103-114
20627899-6	2010	Further studies were performed to analyse whether Fe deficiency up-regulates the expression of genes involved in ethylene biosynthesis [S-adenosylmethionine synthetase, 1-aminocyclopropane-1-carboxylate (ACC) synthase, and ACC oxidase genes] and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3).	Iron	50-52	ETHYLENE-INSENSITIVE3-like 3	Arabidopsis thaliana	302-308
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	1-aminocyclopropane-1-carboxylate synthase 4	Arabidopsis thaliana	121-127
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	1-aminocyclopropane-1-carboxylate synthase 9	Arabidopsis thaliana	137-143
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	ETHYLENE-INSENSITIVE3-like 3	Arabidopsis thaliana	225-231
20797577-12	2010	CONCLUSION: A low hepcidin level in hemodialysis patients with high epoetin resistance index could be a useful marker of iron-restricted erythropoiesis, but confirmation by a therapeutical trial is necessary.	Iron	121-125	erythropoietin	Homo sapiens	68-75
21072355-1	2010	A sample preparation strategy for the determination of the Fe-containing enzyme catalase (CAT) by Fe specific monitoring in human erythrocytes has been optimized.	Iron	59-61	catalase	Homo sapiens	90-93
21072355-1	2010	A sample preparation strategy for the determination of the Fe-containing enzyme catalase (CAT) by Fe specific monitoring in human erythrocytes has been optimized.	Iron	98-100	catalase	Homo sapiens	80-88
21072355-1	2010	A sample preparation strategy for the determination of the Fe-containing enzyme catalase (CAT) by Fe specific monitoring in human erythrocytes has been optimized.	Iron	98-100	catalase	Homo sapiens	90-93
20633231-1	2010	Pathogenic bacteria in the Neisseriaceae possess a surface receptor mediating iron acquisition from human transferrin (hTf) that consists of a transmembrane iron transporter (TbpA) and a surface-exposed lipoprotein (TbpB).	Iron	78-82	transferrin	Homo sapiens	106-117
20814119-7	2010	There was an increase of MDA (21.97 + 3.65% vs 7.06 + 3.65%) and highly sensitive C-reactive protein (HsCRP) (11.19 + 24.63% vs 13.19 + 7.7%) after iron administration both in the placebo and the NAC groups.	Iron	148-152	C-reactive protein	Homo sapiens	82-100
21117298-3	2010	The determining factor in the mechanism of iron acquisition is lipopolysaccharide (LPS) of virulent bacteria that by itself or with the help of siderophores provides iron that is an essential microelement for bacterial growth.	Iron	43-47	toll-like receptor 4	Mus musculus	83-86
20553779-2	2010	Hepcidin, a recently discovered peptide hormone, regulates iron uptake and metabolism, protecting the body from iron overload.	Iron	59-63	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
20553779-2	2010	Hepcidin, a recently discovered peptide hormone, regulates iron uptake and metabolism, protecting the body from iron overload.	Iron	112-116	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
20553779-9	2010	The upregulation was specific for hepcidin, since other iron-related genes (hemojuvelin, IREG-1) remained unchanged.	Iron	56-60	hepcidin antimicrobial peptide	Rattus norvegicus	34-42
20553779-13	2010	It is speculated that upregulation of hepcidin may reduce iron toxicity and thus infarct size expansion in an infarcted heart.	Iron	58-62	hepcidin antimicrobial peptide	Rattus norvegicus	38-46
21117298-3	2010	The determining factor in the mechanism of iron acquisition is lipopolysaccharide (LPS) of virulent bacteria that by itself or with the help of siderophores provides iron that is an essential microelement for bacterial growth.	Iron	166-170	toll-like receptor 4	Mus musculus	83-86
21117298-4	2010	The crucial role, especially in the acquisition of iron in animal hosts, is played by LPS and it should be considered as the virulent factor of invasive bacteria.	Iron	51-55	toll-like receptor 4	Mus musculus	86-89
20572014-8	2010	The structure is consistent with the fact that introduction of two mutations in the N-lobe of murine ICA (mICA) (W124R and S188Y) allowed it to bind iron with high affinity.	Iron	149-153	inhibitor of carbonic anhydrase	Mus musculus	101-104
20572014-8	2010	The structure is consistent with the fact that introduction of two mutations in the N-lobe of murine ICA (mICA) (W124R and S188Y) allowed it to bind iron with high affinity.	Iron	149-153	inhibitor of carbonic anhydrase	Mus musculus	106-110
20572014-9	2010	Unexpectedly, both lobes of the mICA were found in the closed conformation usually associated with presence of iron in the cleft, and making the structure most similar to diferric pig TF.	Iron	111-115	inhibitor of carbonic anhydrase	Mus musculus	32-36
20684597-1	2010	As recently discovered, matriptase-2, a type II transmembrane serine protease, plays a crucial role in body iron homeostasis by down-regulating hepcidin expression, which results in increased iron levels.	Iron	108-112	transmembrane serine protease 6	Homo sapiens	24-36
20723262-0	2010	Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis.	Iron	20-24	vascular endothelial growth factor A	Homo sapiens	56-90
20723262-4	2010	In the present study, we hypothesized that iron deficiency, a common ailment in young women, contributes to the poor outcome by promoting the hypoxia inducible factor-1alpha (HIF-1alpha and vascular endothelial growth factor (VEGF) formation.	Iron	43-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-173
20723262-4	2010	In the present study, we hypothesized that iron deficiency, a common ailment in young women, contributes to the poor outcome by promoting the hypoxia inducible factor-1alpha (HIF-1alpha and vascular endothelial growth factor (VEGF) formation.	Iron	43-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	175-185
20723262-4	2010	In the present study, we hypothesized that iron deficiency, a common ailment in young women, contributes to the poor outcome by promoting the hypoxia inducible factor-1alpha (HIF-1alpha and vascular endothelial growth factor (VEGF) formation.	Iron	43-47	vascular endothelial growth factor A	Homo sapiens	190-224
20723262-4	2010	In the present study, we hypothesized that iron deficiency, a common ailment in young women, contributes to the poor outcome by promoting the hypoxia inducible factor-1alpha (HIF-1alpha and vascular endothelial growth factor (VEGF) formation.	Iron	43-47	vascular endothelial growth factor A	Homo sapiens	226-230
20723262-10	2010	The molecular mechanism appears that cellular iron deficiency elevates VEGF formation by stabilizing HIF-1alpha.	Iron	46-50	vascular endothelial growth factor A	Homo sapiens	71-75
20723262-10	2010	The molecular mechanism appears that cellular iron deficiency elevates VEGF formation by stabilizing HIF-1alpha.	Iron	46-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
20723262-12	2010	CONCLUSIONS: Cellular iron deficiency increased HIF-1alpha, VEGF, and angiogenesis, suggesting that systemic iron deficiency might play an important part in the tumor angiogenesis and recurrence in this young age group of breast cancer patients.	Iron	22-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
20723262-12	2010	CONCLUSIONS: Cellular iron deficiency increased HIF-1alpha, VEGF, and angiogenesis, suggesting that systemic iron deficiency might play an important part in the tumor angiogenesis and recurrence in this young age group of breast cancer patients.	Iron	22-26	vascular endothelial growth factor A	Homo sapiens	60-64
20684597-1	2010	As recently discovered, matriptase-2, a type II transmembrane serine protease, plays a crucial role in body iron homeostasis by down-regulating hepcidin expression, which results in increased iron levels.	Iron	192-196	transmembrane serine protease 6	Homo sapiens	24-36
20684597-2	2010	Thus, matriptase-2 represents a novel target for the development of enzyme inhibitors potentially useful for the treatment of systemic iron overload (hemochromatosis).	Iron	135-139	transmembrane serine protease 6	Homo sapiens	6-18
20519508-2	2010	Having previously shown that the functional expression of NRAMP-1 results in increased protein phosphorylation mediated in part by an iron-dependent inhibition of Mvarphi protein-tyrosine phosphatase (PTP) activity, we sought to study the mechanism(s) underlying this specific event.	Iron	134-138	solute carrier family 11 member 1	Homo sapiens	58-65
20581683-2	2010	RECENT FINDINGS: Recent discoveries have uncovered the iron-dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms.	Iron	55-59	RLS1	Homo sapiens	83-86
20579638-5	2010	Thus, OGFOD1 plays an important role in ischemic cell survival and an OGFOD1 iron binding residue is required for ATPAF1 gene expression.	Iron	77-81	2-oxoglutarate and iron dependent oxygenase domain containing 1	Homo sapiens	70-76
20712765-2	2010	Threshold values for iron toxicity are a liver iron concentration exceeding 440 mmoles/g dry weight, serum ferritin &gt;2500 ng/mL, DFO urinary iron excretion &gt;20 mg/day, and transferrin saturation &gt;75%.	Iron	21-25	transferrin	Homo sapiens	178-189
20712765-3	2010	The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of non-transferrin-bound iron (NTBI).	Iron	28-32	transferrin	Homo sapiens	76-87
20712765-3	2010	The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of non-transferrin-bound iron (NTBI).	Iron	28-32	transferrin	Homo sapiens	120-131
20712765-3	2010	The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of non-transferrin-bound iron (NTBI).	Iron	50-54	transferrin	Homo sapiens	76-87
20712765-3	2010	The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of non-transferrin-bound iron (NTBI).	Iron	50-54	transferrin	Homo sapiens	76-87
20712765-4	2010	NTBI is cleared preferentially by the liver and myocardium at a rate exceeding 200 times that of transferrin iron.	Iron	109-113	transferrin	Homo sapiens	97-108
20581683-2	2010	RECENT FINDINGS: Recent discoveries have uncovered the iron-dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms.	Iron	55-59	RLS1	Homo sapiens	139-142
20410187-5	2010	The function of miR-Let-7d in erythroid cells was evaluated by the flow cytometry analysis of erythroid differentiation markers, by benzidine staining and by iron flame atomic absorption for the evaluation of iron concentration in the endosomes from K562 cells over-expressing miR-Let-7d.	Iron	158-162	microRNA let-7d	Homo sapiens	16-26
20618438-2	2010	It influences cellular iron concentrations through multiple mechanisms, including regulation of transferrin binding to transferrin receptors.	Iron	23-27	transferrin	Homo sapiens	96-107
20618438-2	2010	It influences cellular iron concentrations through multiple mechanisms, including regulation of transferrin binding to transferrin receptors.	Iron	23-27	transferrin	Homo sapiens	119-130
20394798-0	2010	Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.	Iron	60-64	solute carrier family 11 member 1	Homo sapiens	5-11
20394798-6	2010	Compared to macrophages singly deficient in either DMT1 or Nramp1 transport ability, macrophages where DMT1 and Nramp1 were both compromised exhibited an abrogated increase in labile iron pool content, released less iron, and experienced diminished upregulation of ferroportin and heme-oxygenase 1 levels following erythrophagocytosis.	Iron	183-187	solute carrier family 11 member 1	Homo sapiens	112-118
20394798-7	2010	CONCLUSIONS: These results suggest that although the loss of either Nramp1 or DMT1 transport ability results in minor impairment after erythrophagocytosis, the simultaneous loss of both Nramp1 and DMT1 iron transport activity is detrimental to the iron recycling capacity of the macrophage.	Iron	248-252	solute carrier family 11 member 1	Homo sapiens	68-74
20394798-7	2010	CONCLUSIONS: These results suggest that although the loss of either Nramp1 or DMT1 transport ability results in minor impairment after erythrophagocytosis, the simultaneous loss of both Nramp1 and DMT1 iron transport activity is detrimental to the iron recycling capacity of the macrophage.	Iron	248-252	solute carrier family 11 member 1	Homo sapiens	186-192
20179090-2	2010	Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin.	Iron	65-69	heme oxygenase 1	Mus musculus	0-16
20179090-2	2010	Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin.	Iron	131-135	heme oxygenase 1	Mus musculus	0-16
20179090-7	2010	RESULTS: We show that iron export protein ferroportin is transcriptionally co-regulated with heme oxygenase 1 by heme, a degradation product of hemoglobin.	Iron	22-26	heme oxygenase 1	Mus musculus	93-109
20179090-10	2010	CONCLUSIONS: This finding suggests that heme controls a macrophage iron recycling regulon involving Btb and Cnc Homology 1 and Nuclear Factor Erythroid 2-like to assure the coordinated degradation of heme by heme oxygenase 1, iron storage and detoxification by ferritin, and iron export by iron export protein ferroportin.	Iron	67-71	heme oxygenase 1	Mus musculus	208-224
20410187-5	2010	The function of miR-Let-7d in erythroid cells was evaluated by the flow cytometry analysis of erythroid differentiation markers, by benzidine staining and by iron flame atomic absorption for the evaluation of iron concentration in the endosomes from K562 cells over-expressing miR-Let-7d.	Iron	209-213	microRNA let-7d	Homo sapiens	16-26
20410187-9	2010	MiR-Let-7d impairs erythroid differentiation of K562 cells by accumulation of iron in the endosomes.	Iron	78-82	microRNA let-7d	Homo sapiens	4-10
20649822-9	2010	Iron chelation significantly decreased the oxidative markers in plasma, liver and the lung and lowered activities of pulmonary SOD and PAF-AcH.	Iron	0-4	phospholipase A2 group VII	Sus scrofa	135-142
20410187-10	2010	CONCLUSIONS: Overall, these data suggest that miR-Let-7d participates in the finely tuned regulation of iron metabolism by targeting DMT1-IRE isoform in erythroid cells.	Iron	104-108	microRNA let-7d	Homo sapiens	46-56
19615879-2	2010	The peptide hormone hepcidin is thought to play a central role in iron homeostasis and its expression is induced by iron overloading and inflammation.	Iron	66-70	hepcidin antimicrobial peptide	Rattus norvegicus	20-28
19615879-2	2010	The peptide hormone hepcidin is thought to play a central role in iron homeostasis and its expression is induced by iron overloading and inflammation.	Iron	116-120	hepcidin antimicrobial peptide	Rattus norvegicus	20-28
19615879-9	2010	Hepcidin is strongly induced in cardiomyocytes under myocarditis and MI, conditions in which inflammatory cytokine levels increase and may play an important role in iron homeostasis and free radical generation.	Iron	165-169	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
20627190-0	2010	Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone.	Iron	61-65	transferrin	Homo sapiens	43-54
20399859-0	2010	Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation.	Iron	113-117	pantothenate kinase 2	Homo sapiens	0-21
20399859-0	2010	Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation.	Iron	113-117	pantothenate kinase 2	Homo sapiens	23-28
20399859-3	2010	We downregulated Pank2 in some cell lines by using specific siRNAs to study its effect on iron homeostasis.	Iron	90-94	pantothenate kinase 2	Homo sapiens	17-22
20399859-7	2010	The strong Pank2-mediated alteration of ferroportin expression in some cell types might alter iron transfer to the brain and be connected with brain iron accumulation.	Iron	94-98	pantothenate kinase 2	Homo sapiens	11-16
20399859-7	2010	The strong Pank2-mediated alteration of ferroportin expression in some cell types might alter iron transfer to the brain and be connected with brain iron accumulation.	Iron	149-153	pantothenate kinase 2	Homo sapiens	11-16
20427704-2	2010	Previously, we showed that Mfrn1 interacts with Abcb10 to enhance mitochondrial iron importation.	Iron	80-84	ATP binding cassette subfamily B member 10	Homo sapiens	48-54
20629144-1	2010	Neurodegeneration with brain iron accumulation (NBIA) is etiologically, clinically, and by imaging a heterogeneous group including NBIA types 1 [pantothenate kinase-associated neurodegeneration (PKAN)] and 2 (PLA2G6-associated neurodegeneration), neuroferritinopathy, and aceruloplasminaemia.	Iron	29-33	pantothenate kinase 2	Homo sapiens	145-207
20629144-1	2010	Neurodegeneration with brain iron accumulation (NBIA) is etiologically, clinically, and by imaging a heterogeneous group including NBIA types 1 [pantothenate kinase-associated neurodegeneration (PKAN)] and 2 (PLA2G6-associated neurodegeneration), neuroferritinopathy, and aceruloplasminaemia.	Iron	29-33	phospholipase A2 group VI	Homo sapiens	209-215
20427704-7	2010	Our findings imply that Fech forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.	Iron	122-126	ATP binding cassette subfamily B member 10	Homo sapiens	72-78
20549723-1	2010	An iron-based metal-organic framework, [Fe(BTC)] (BTC: 1,3,5-benzenetricarboxylate) is an efficient catalyst in the ring opening of styrene oxide with alcohols and aniline under mild reaction conditions.	Iron	3-7	betacellulin	Homo sapiens	43-46
20549723-5	2010	The analogous compound [Cu(3)(BTC)(2)] was also found to be effective, although with somewhat lower activity than [Fe(BTC)].	Iron	115-117	betacellulin	Homo sapiens	30-33
20549723-5	2010	The analogous compound [Cu(3)(BTC)(2)] was also found to be effective, although with somewhat lower activity than [Fe(BTC)].	Iron	115-117	betacellulin	Homo sapiens	118-121
20599734-4	2010	Upon oxidation of the heme iron in Cyt c, the average S2 value was increased from 0.88+/-0.01 to 0.92+/-0.01, demonstrating that the mobility of the backbone is further restricted in the oxidized form.	Iron	27-31	cytochrome c, somatic	Homo sapiens	35-40
20549723-1	2010	An iron-based metal-organic framework, [Fe(BTC)] (BTC: 1,3,5-benzenetricarboxylate) is an efficient catalyst in the ring opening of styrene oxide with alcohols and aniline under mild reaction conditions.	Iron	3-7	betacellulin	Homo sapiens	50-53
20450229-8	2010	We also observed that a higher iron purity led to an increased IMAC enrichment efficiency.	Iron	31-35	uncoordinated-104	Drosophila melanogaster	63-67
20388583-0	2010	Effect of reaction environments on the reactivity of PCB (2-chlorobiphenyl) over activated carbon impregnated with palladized iron.	Iron	22-26	pyruvate carboxylase	Homo sapiens	53-56
20407036-3	2010	To address the basis for iron regulation of erythropoiesis, we established primary hematopoietic cultures with transferrin saturation levels that restricted erythropoiesis but permitted granulopoiesis and megakaryopoiesis.	Iron	25-29	transferrin	Homo sapiens	111-122
20550131-7	2010	NMR, IR studies, and DFT calculations of iron complexes, which are formed under reaction conditions, confirm that PPh(3) plays an active role in the catalytic cycle and that N-ligands enhance the stability of the system.	Iron	41-45	caveolin 1	Homo sapiens	114-120
20439772-5	2010	Surprisingly, only a subset of mutants identified are sensitive to extracellular iron fluctuations or display genetic interactions with mutants of iron regulon genes AFT2 or FET3.	Iron	147-151	Aft2p	Saccharomyces cerevisiae S288C	166-170
20724768-10	2010	After 8 weeks of iron tablets, the study also noted, increasing of plasma IL-2 and IFNgamma.	Iron	17-21	interleukin 2	Homo sapiens	74-91
20724768-12	2010	CONCLUSION: concentration of IL2 dan IFNgamma in plasma significantly increased after administration of iron tablets for 8 weeks as compared to that before iron treatment.	Iron	104-108	interleukin 2	Homo sapiens	29-32
20724768-12	2010	CONCLUSION: concentration of IL2 dan IFNgamma in plasma significantly increased after administration of iron tablets for 8 weeks as compared to that before iron treatment.	Iron	104-108	interferon gamma	Homo sapiens	37-45
20724768-12	2010	CONCLUSION: concentration of IL2 dan IFNgamma in plasma significantly increased after administration of iron tablets for 8 weeks as compared to that before iron treatment.	Iron	156-160	interleukin 2	Homo sapiens	29-32
20724768-12	2010	CONCLUSION: concentration of IL2 dan IFNgamma in plasma significantly increased after administration of iron tablets for 8 weeks as compared to that before iron treatment.	Iron	156-160	interferon gamma	Homo sapiens	37-45
22993593-14	2010	Our data suggest that iron overload in patients with CH-C derives from Zn deficiency and thereby causes insulin resistance.	Iron	22-26	insulin	Homo sapiens	104-111
20724768-0	2010	Influence of iron on plasma interleukin-2 and gamma interferon level in iron deficiency anemia.	Iron	13-17	interleukin 2	Homo sapiens	28-41
20724768-1	2010	AIM: to find out the the influence of iron on the levels of plasma IL-2 and IFNgamma in iron deficiency anemia patient.	Iron	38-42	interleukin 2	Homo sapiens	67-71
20724768-1	2010	AIM: to find out the the influence of iron on the levels of plasma IL-2 and IFNgamma in iron deficiency anemia patient.	Iron	38-42	interferon gamma	Homo sapiens	76-84
20606661-0	2010	Editorial: improved efficacy of biological maintenance therapy in "early" compared with "late" Crohn"s disease: strike while the iron is hot with anti-TNF agents?	Iron	129-133	tumor necrosis factor	Homo sapiens	151-154
20408812-0	2010	Transferrin-iron routing to the cytosol and mitochondria as studied by live and real-time fluorescence.	Iron	12-16	transferrin	Homo sapiens	0-11
20408812-1	2010	In the present study we analysed the mechanism of intracellular routing of iron acquired by erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron].	Iron	75-79	transferrin	Homo sapiens	156-167
20408812-1	2010	In the present study we analysed the mechanism of intracellular routing of iron acquired by erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron].	Iron	169-173	transferrin	Homo sapiens	156-167
20530676-1	2010	The major route of iron uptake by cells occurs through transferrin receptor (TfR)-mediated endocytosis of diferric-charged plasma transferrin (holo-Tf).	Iron	19-23	transferrin	Homo sapiens	55-66
20540689-9	2010	In addition, the mRNA expression of hepcidin was also increased, suggesting blockage of iron recycling through FPN1 in spleen with cisplatin treatment.	Iron	88-92	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	111-115
20540689-11	2010	Hepcidin inhibits the function of FPN1 as iron-exporter leading to iron overloaded inside ferritins of splenic cells, which are stained with abnormal hemosiderin accumulation.	Iron	42-46	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	34-38
20540689-11	2010	Hepcidin inhibits the function of FPN1 as iron-exporter leading to iron overloaded inside ferritins of splenic cells, which are stained with abnormal hemosiderin accumulation.	Iron	67-71	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	34-38
20527775-1	2010	Ferrate(VI) (Fe(VI)O(4)(-), Fe(VI)) and ferrate(V) (Fe(V)O(4)(3-), Fe(V)) have a high oxidizing power and upon decomposition form a nontoxic byproduct, Fe(III), which makes them environmentally friendly oxidants in water and wastewater treatment.	Iron	0-2	FEV transcription factor, ETS family member	Homo sapiens	52-57
20431588-0	2010	Effect of angiotensin II on iron-transporting protein expression and subsequent intracellular labile iron concentration in human glomerular endothelial cells.	Iron	28-32	angiotensinogen	Homo sapiens	10-24
20549524-1	2010	Iron and zinc are essential for normal brain function, yet the mechanisms used by astrocytes to scavenge non-transferrin-bound iron (NTBI) and zinc are not well understood.	Iron	127-131	transferrin	Rattus norvegicus	109-120
20431588-4	2010	When 90% iron-saturated human transferrin (90% Tf) was applied to HGECs without Ang II, the labile ferrous iron level was same as the effect of control in spite of a significant increase in the total cellular iron concentration.	Iron	9-13	transferrin	Homo sapiens	30-41
20431588-4	2010	When 90% iron-saturated human transferrin (90% Tf) was applied to HGECs without Ang II, the labile ferrous iron level was same as the effect of control in spite of a significant increase in the total cellular iron concentration.	Iron	107-111	transferrin	Homo sapiens	30-41
20431588-4	2010	When 90% iron-saturated human transferrin (90% Tf) was applied to HGECs without Ang II, the labile ferrous iron level was same as the effect of control in spite of a significant increase in the total cellular iron concentration.	Iron	107-111	transferrin	Homo sapiens	30-41
20662951-3	2010	It has been proposed that in hemodialysis (HD) patients, iron mobilization (decreased total iron-binding capacity, increased iron level, and transferrin oversaturation) causes a transmetallation reaction and the release of free Gd from its chelator with the deposition of both Gd and iron in the affected tissues leading to fibrosis.	Iron	57-61	transferrin	Homo sapiens	141-152
20516639-7	2010	Taken together, these results reveal that Hrb is a critical Notch target gene that mediates lymphoblast transformation and disease progression via its ability to satisfy the enhanced demands of transformed lymphoblasts for iron.	Iron	223-227	ArfGAP with FG repeats 1	Homo sapiens	42-45
20396936-5	2010	Pure iron possessed similar dynamic blood clotting time, prothrombin time and plasma recalcification time to 316L and Mg-Mn-Zn alloy, but a lower hemolysis ratio and a significant lower number density of adhered platelets.	Iron	5-9	coagulation factor II, thrombin	Homo sapiens	57-68
20726229-10	2010	Under the condition of copper deficiency, the expression of hepcidin mRNA in liver was lowered and the expression of transferrin receptor mRNA was enhanced through the way of iron response element-iron regulatory protein (IRE-IRP) to regulate iron metabolism.	Iron	175-179	transferrin	Rattus norvegicus	117-128
20532993-5	2010	The iron content of HDL(2) and HDL(3) from beta-thal/HbE patients was higher while the cholesterol content was lower than those in healthy volunteers.	Iron	4-8	HDL3	Homo sapiens	31-37
20064616-1	2010	Essential to iron transport and delivery, human serum transferrin (hTF) is a bilobal glycoprotein capable of reversibly binding one ferric ion in each lobe (the N- and C-lobes).	Iron	13-17	transferrin	Homo sapiens	54-65
20799798-0	2010	Real-time observation of the effect of iron on receptor-mediated endocytosis of transferrin conjugated with quantum dots.	Iron	39-43	transferrin	Homo sapiens	80-91
20799798-1	2010	The optical properties of antiphotobleaching and the advantage of long-term fluorescence observation of quantum dots are fully adopted to study the effects of iron on the endocytosis of transferrin.	Iron	159-163	transferrin	Homo sapiens	186-197
20799798-2	2010	Quantum dots are labeled for transferrin and endocytosis of transferrin in HeLa cells is observed under the normal state, iron overloading, and an iron-deficient state.	Iron	122-126	transferrin	Homo sapiens	60-71
20799798-2	2010	Quantum dots are labeled for transferrin and endocytosis of transferrin in HeLa cells is observed under the normal state, iron overloading, and an iron-deficient state.	Iron	147-151	transferrin	Homo sapiens	60-71
20799798-8	2010	We advance a direct observational method that may contribute to further study of the relationship of iron and transferrin.	Iron	101-105	transferrin	Homo sapiens	110-121
20726229-10	2010	Under the condition of copper deficiency, the expression of hepcidin mRNA in liver was lowered and the expression of transferrin receptor mRNA was enhanced through the way of iron response element-iron regulatory protein (IRE-IRP) to regulate iron metabolism.	Iron	197-201	transferrin	Rattus norvegicus	117-128
20472854-5	2010	The baseline values of serum ferritin and percentage of transferrin saturation were poor predictors of iron responsiveness.	Iron	103-107	transferrin	Homo sapiens	56-67
20565922-0	2010	Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis.	Iron	92-96	mitoferrin	Drosophila melanogaster	11-21
20565922-4	2010	Here we investigate the role of Drosophila mitoferrin (dmfrn), which is a mitochondrial carrier protein with an established role in the mitochondrial iron metabolism, during spermatogenesis.	Iron	150-154	mitoferrin	Drosophila melanogaster	43-53
20565922-4	2010	Here we investigate the role of Drosophila mitoferrin (dmfrn), which is a mitochondrial carrier protein with an established role in the mitochondrial iron metabolism, during spermatogenesis.	Iron	150-154	mitoferrin	Drosophila melanogaster	55-60
20525315-16	2010	The liberated iron is transported by transferrin and reutilized for hemoglobin synthesis in the erythroid system.	Iron	14-18	transferrin	Homo sapiens	37-48
20481466-5	2010	Fe-S cluster biogenesis takes place essentially in every tissue of humans, and products of human disease genes, including frataxin, GLRX5, ISCU, and ABCB7, have important roles in the process.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	139-143
20481518-1	2010	The tetranuclear iron complex Fe(4)[MeC(CH(2)S)(3)](2)(CO)(8) (1) functions like a hydrogenase to catalyze proton reduction to H(2) in the presence of 2,6-dimethylpyridinium acid (LutH(+)).	Iron	17-21	C-C motif chemokine ligand 28	Homo sapiens	36-39
20155302-1	2010	Bacteria that inhabit the respiratory and genitourinary tracts of mammals encounter an iron-deficient environment on the mucosal surface where iron is complexed by the host iron-binding proteins transferrin and lactoferrin.	Iron	87-91	transferrin	Homo sapiens	195-206
20378827-3	2010	HO1 catalyzes the breakdown of heme into iron, biliverdin and, carbon monoxide (CO).	Iron	41-45	heme oxygenase 1	Mus musculus	0-3
19727574-6	2010	Here, we report the in vitro inhibitory effects of some metal ions, including Pb(+2), Cr(+2), Fe(+2), and Zn(+2), on the activity of human serum PON1 (hPON1; EC 3.1.8.1.).	Iron	94-96	paraoxonase 1	Homo sapiens	145-149
20206689-1	2010	Hereditary myopathy with lactic acidosis, or myopathy with exercise intolerance, Swedish type (OMIM #255125) is caused by mutations in the iron-sulfur cluster scaffold (ISCU) gene.	Iron	139-143	iron-sulfur cluster assembly enzyme	Homo sapiens	169-173
20206689-5	2010	Consistent with the recognised role of ISCU, we found abnormal activities of respiratory chain complexes containing iron-sulfur clusters in patient muscle.	Iron	116-120	iron-sulfur cluster assembly enzyme	Homo sapiens	39-43
20155302-1	2010	Bacteria that inhabit the respiratory and genitourinary tracts of mammals encounter an iron-deficient environment on the mucosal surface where iron is complexed by the host iron-binding proteins transferrin and lactoferrin.	Iron	105-109	transferrin	Homo sapiens	195-206
20155302-1	2010	Bacteria that inhabit the respiratory and genitourinary tracts of mammals encounter an iron-deficient environment on the mucosal surface where iron is complexed by the host iron-binding proteins transferrin and lactoferrin.	Iron	105-109	transferrin	Homo sapiens	195-206
20100190-10	2010	These studies demonstrate that maternal iron-restricted diets enhance the incidence of alopecia in IL-10-deficient mouse pups and suggest mast cells as potential effector cells.	Iron	40-44	interleukin 10	Mus musculus	99-104
20460527-4	2010	We previously developed two mutant Tf molecules, K206E/R632A Tf and K206E/K534A Tf, in which iron is locked into each of the two homologous lobes.	Iron	93-97	transferrin	Homo sapiens	35-37
20010783-6	2010	TNF-induced necroptosis depends on receptor-interacting protein-1 kinase, mitochondrial complex I and cytosolic phospholipase A(2) activities, whereas H(2)O(2)-induced necrosis requires iron-dependent Fenton reactions.	Iron	186-190	tumor necrosis factor	Homo sapiens	0-3
23199069-6	2010	This review will discuss novel pharmacological approaches concerning adjusted therapy for ALS patients: iron-binding brain permeable multimodal compounds, genetic manipulation and cell-based treatment.	Iron	104-108	superoxide dismutase 1	Homo sapiens	90-93
20398641-4	2010	The peroxidase activity of Cyt c proceeded via the opening of the tertiary structure of Cyt c, as suggested by the loss of the sixth coordination bond of the heme-iron.	Iron	163-167	cytochrome c, somatic	Homo sapiens	27-32
20398641-4	2010	The peroxidase activity of Cyt c proceeded via the opening of the tertiary structure of Cyt c, as suggested by the loss of the sixth coordination bond of the heme-iron.	Iron	163-167	cytochrome c, somatic	Homo sapiens	88-93
20524813-5	2010	Conversely, iron withholding and/or removal is an important defense strategy for mammalian hosts, which is primarily accomplished by the iron chelating proteins transferrin and lactoferrin.	Iron	12-16	transferrin	Homo sapiens	161-172
20712260-4	2010	There is little direct information available to confirm the correlation between the oxidative stress, iron overload and insulin resistance in SCD patients.	Iron	102-106	insulin	Homo sapiens	120-127
20524813-5	2010	Conversely, iron withholding and/or removal is an important defense strategy for mammalian hosts, which is primarily accomplished by the iron chelating proteins transferrin and lactoferrin.	Iron	137-141	transferrin	Homo sapiens	161-172
20524817-4	2010	Acute experiments in male Wistar rats demonstrated the prooxidant effect of iron on the selenoenzymes thioredoxin reductase (TrxR) and glutathione peroxidase (GPx).	Iron	76-80	peroxiredoxin 5	Rattus norvegicus	102-123
20524817-4	2010	Acute experiments in male Wistar rats demonstrated the prooxidant effect of iron on the selenoenzymes thioredoxin reductase (TrxR) and glutathione peroxidase (GPx).	Iron	76-80	peroxiredoxin 5	Rattus norvegicus	125-129
20524817-6	2010	Deferiprone (L1) has been shown to abolish the stimulating effect of iron on lipid peroxidation and reduced glutathione (GSH) levels, and also to inhibit the influence of iron on the activity of TrxR and GPx.	Iron	171-175	peroxiredoxin 5	Rattus norvegicus	195-199
20524817-7	2010	Similarly, the flavonoid quercetin abolished the influence of iron on the activity of TrxR.	Iron	62-66	peroxiredoxin 5	Rattus norvegicus	86-90
20484814-5	2010	Elevated concentrations of glucose and iron, consistent with those seen during DKA, enhanced GRP78 expression and the resulting R. oryzae invasion and damage of endothelial cells in a receptor-dependent manner.	Iron	39-43	heat shock protein 5	Mus musculus	93-98
20381373-6	2010	A S. cerevisiae mitochondrial glutaredoxin grx5 mutant, defective in assembly of Fe-S clusters critical for Complex III function, displayed increased sensitivity to PDT.	Iron	81-85	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	43-47
20406921-2	2010	Because interleukin-6 (IL-6) induces expression of hepcidin, one of the principal regulators of iron metabolism, we studied the contribution of hepcidin in anemia in HL at diagnosis.	Iron	96-100	interleukin 6	Homo sapiens	23-27
20609178-16	2010	In other words, if the serum ferritin is &lt;100 ng/mL and the transferrin saturation rate (TSAT) is &lt;20%, then the criteria for iron supplementation will be met; if only one of these criteria is met, then iron supplementation should be considered unnecessary.	Iron	132-136	transferrin	Homo sapiens	63-74
19855947-8	2010	Recent studies also reveal an important role of cPLA2 in modulating neuronal excitatory functions, sPLA2 in the inflammatory responses, and iPLA2 with childhood neurologic disorders associated with brain iron accumulation.	Iron	204-208	phospholipase A2 group VI	Homo sapiens	140-145
19887861-1	2010	BACKGROUND: In hypoxic newborns, cardiac troponin T (cTnT) was shown to be an indicator of cardiac damage and increased levels of nonprotein-bound iron (NPBI), an indicator of increased free radical production and perinatal brain damage.	Iron	147-151	troponin T2, cardiac type	Homo sapiens	53-57
20642102-8	2010	Taking into account the depletion of body iron stores evaluated by the transferrin saturation, only the value of MCV and GGT may be partially useful.	Iron	42-46	transferrin	Homo sapiens	71-82
20642102-10	2010	CONCLUSION: From these studies suggest that the body iron stores in alcoholics affect the indices of liver damage by alcohol (GGT AST and ALT) and the alcohol abuse markers (CDT and MCV) affect only a small extent.	Iron	53-57	solute carrier family 17 member 5	Homo sapiens	130-133
20416277-3	2010	Here, we unveil a new action of hinokitiol, an iron chelator found in natural plants, on stabilization of HIF-1alpha in cell cultures in a dose-dependent manner.	Iron	47-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
20302851-7	2010	By co-overloading of Cu and Fe, Cu-overload-related single liver cell toxicity and regeneration increased, as did cytokine imbalances involving increased cyclooxygenase-2-producing Kupffer cells and accumulation of malondialdehyde within GST-P(+) foci.	Iron	28-30	glutathione S-transferase pi 1	Rattus norvegicus	238-243
19945753-3	2010	These mechanisms are mediated by hepcidin, a 25 amino acids peptide synthesized mainly in the liver in response to iron stores and inflammation.	Iron	115-119	hepcidin	Equus caballus	33-41
19945753-5	2010	Hepcidin up-regulation is particularly useful during acute inflammation, especially before adaptive immunity occurs, restricting iron availability necessary for pathogenic microorganism growth.	Iron	129-133	hepcidin	Equus caballus	0-8
20428565-3	2010	Here we present Fe L(2,3)-edge X-ray absorption spectra of these proteins in physiological solutions, which reveal clear differences in their electronic structures, in that pi back-donation of the Fe atom occurs in catalase, which confers on it a partial ferryl (Fe(4+)) character, while this is not the case in methaemoglobin.	Iron	16-18	catalase	Homo sapiens	215-223
20307259-2	2010	This plasma membrane redox system appears to transfer electrons from intracellular ascorbate to extracellular oxidants (e.g. non-transferrin-bound iron).	Iron	147-151	transferrin	Homo sapiens	129-140
20347849-5	2010	In addition, similar to human Grx2, Grx6 binds GSH via an iron-sulfur cluster in vitro.	Iron	58-62	glutathione-disulfide reductase GRX6	Saccharomyces cerevisiae S288C	36-40
20428565-3	2010	Here we present Fe L(2,3)-edge X-ray absorption spectra of these proteins in physiological solutions, which reveal clear differences in their electronic structures, in that pi back-donation of the Fe atom occurs in catalase, which confers on it a partial ferryl (Fe(4+)) character, while this is not the case in methaemoglobin.	Iron	197-199	catalase	Homo sapiens	215-223
20081092-6	2010	Lower iron was significantly correlated with higher IL-6 and CRP.	Iron	6-10	interleukin 6	Homo sapiens	52-56
20081092-7	2010	Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin.	Iron	85-89	C-reactive protein	Homo sapiens	36-39
20081092-6	2010	Lower iron was significantly correlated with higher IL-6 and CRP.	Iron	6-10	C-reactive protein	Homo sapiens	61-64
20081092-7	2010	Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin.	Iron	85-89	interleukin 6	Homo sapiens	27-31
20449817-1	2010	The bovine transferrin gene (TF) is located at 125 cM on bovine chromosome 1 (BTA1); it codes for transferrin, a glycoprotein that is highly conserved in many species and that is responsible for iron transport.	Iron	195-199	serotransferrin	Bos taurus	11-22
20449817-1	2010	The bovine transferrin gene (TF) is located at 125 cM on bovine chromosome 1 (BTA1); it codes for transferrin, a glycoprotein that is highly conserved in many species and that is responsible for iron transport.	Iron	195-199	serotransferrin	Bos taurus	98-109
20404192-1	2010	The primary route of iron acquisition in vertebrates is the transferrin receptor (TfR) mediated endocytotic pathway, which provides cellular entry to the metal transporter serum transferrin (Tf).	Iron	21-25	transferrin	Homo sapiens	60-71
20382967-0	2010	ClpC1, an ATP-dependent Clp protease in plastids, is involved in iron homeostasis in Arabidopsis leaves.	Iron	65-69	CLPC homologue 1	Arabidopsis thaliana	0-5
20382967-12	2010	In addition to its known functions reported previously, ClpC1 is involved in leaf Fe homeostasis, presumably via chloroplast translocation of some nuclear-encoded proteins which function in Fe transport.	Iron	82-84	CLPC homologue 1	Arabidopsis thaliana	56-61
20382967-9	2010	The leaf chlorosis of the mutant irm1 and clpc1 (a T-DNA-inserted null mutant of ClpC1) could be converted to green by watering the soil with Fe solution.	Iron	142-144	CLPC homologue 1	Arabidopsis thaliana	42-47
20382967-9	2010	The leaf chlorosis of the mutant irm1 and clpc1 (a T-DNA-inserted null mutant of ClpC1) could be converted to green by watering the soil with Fe solution.	Iron	142-144	CLPC homologue 1	Arabidopsis thaliana	81-86
20224575-3	2010	Here, we report that existence of the Hsp70 Ssq1, which arose by duplication of the gene encoding multifunction mtHsp70 and specializes in iron-sulphur cluster biogenesis, correlates with functional and structural changes in the J domain of its J-protein partner Jac1.	Iron	139-143	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	44-48
20102755-4	2010	Changes in intracellular iron status were determined by measuring alterations in gene and protein expression of transferrin receptor and ferritin light chain and heavy chain.	Iron	25-29	transferrin	Rattus norvegicus	112-123
20138212-8	2010	The depletion and aggregation of TDP-43 were associated with the specific action of Zn but were not seen with copper, iron, or H(2)O(2).	Iron	118-122	TAR DNA binding protein	Homo sapiens	33-39
20232450-1	2010	Mutations leading to abrogation of matriptase-2 proteolytic activity in humans are associated with an iron-refractory iron deficiency anemia (IRIDA) due to elevated hepcidin levels.	Iron	102-106	transmembrane serine protease 6	Homo sapiens	35-47
20113186-1	2010	BACKGROUND: The correlation between body iron stores and inflammation with insulin resistance in type 2 diabetes is not thoroughly investigated, especially in the Persian population.	Iron	41-45	insulin	Homo sapiens	75-82
20176792-4	2010	Using iron-deficient, chemically defined medium, we determined that H. pylori can bind and extract iron from hemoglobin, transferrin, and lactoferrin.	Iron	99-103	transferrin	Homo sapiens	121-132
20176792-6	2010	Unlike other pathogens, H. pylori preferentially binds the iron-free forms of transferrin and lactoferrin, which limits its ability to extract iron from normal serum, which is not iron saturated.	Iron	59-63	transferrin	Homo sapiens	78-89
20176792-6	2010	Unlike other pathogens, H. pylori preferentially binds the iron-free forms of transferrin and lactoferrin, which limits its ability to extract iron from normal serum, which is not iron saturated.	Iron	143-147	transferrin	Homo sapiens	78-89
20176792-6	2010	Unlike other pathogens, H. pylori preferentially binds the iron-free forms of transferrin and lactoferrin, which limits its ability to extract iron from normal serum, which is not iron saturated.	Iron	143-147	transferrin	Homo sapiens	78-89
20113186-8	2010	Serum iron even in the normal range had positive correlation with insulin resistance.	Iron	6-10	insulin	Homo sapiens	66-73
20208481-1	2010	Increased iron deposition is often seen in liver explants with alpha-1-antitrypsin deficiency, but it remains unclear if this is a nonspecific effect of end-stage liver disease or if individuals with alpha-1-antitrypsin deficiency and excess iron are at increased risk for HFE mutations.	Iron	10-14	serpin family A member 1	Homo sapiens	63-82
20041272-2	2010	Transferrin receptor 1 (R(D)) binds iron-loaded transferrin and allows its internalization in the cytoplasm.	Iron	36-40	transferrin	Homo sapiens	0-11
20041272-2	2010	Transferrin receptor 1 (R(D)) binds iron-loaded transferrin and allows its internalization in the cytoplasm.	Iron	36-40	transferrin	Homo sapiens	48-59
20041272-3	2010	Human serum transferrin also forms complexes with metals other than iron, including uranium in the uranyl form (UO(2)(2+)).	Iron	68-72	transferrin	Homo sapiens	12-23
20041272-4	2010	Can the uranyl-saturated transferrin (TUr(2)) follow the receptor-mediated iron-acquisition pathway?	Iron	75-79	transferrin	Homo sapiens	25-36
20041272-8	2010	This kinetic analysis implies in the proposed in vitro model possible but weak competition between TUr(2) and the C-lobe of iron-loaded transferrin toward the interaction with R(D).	Iron	124-128	transferrin	Homo sapiens	136-147
20208481-3	2010	Interestingly, the alpha-1-antitrypsin cirrhotic livers showed a bimodal distribution of iron accumulation, with peaks at grades 1 and 3.	Iron	89-93	serpin family A member 1	Homo sapiens	19-38
20208481-7	2010	However, there was a significant association with HFE mutations in alpha-1-antitrypsin deficiency livers with grade 3+ or 4+ iron, P=0.02.	Iron	125-129	serpin family A member 1	Homo sapiens	67-86
20303700-2	2010	There are two different phenotypes of RLS: an early-onset form, starting before 36 years old with mostly a familial history, being mostly severe and highly genetically determined, with a high dependence to iron brain levels; a delayed-onset form, starting after 36 years old, mostly secondary, without familial history, with a rapid evolution in two or three years, and with frequent low ferritine serum levels.	Iron	206-210	RLS1	Homo sapiens	38-41
20338211-0	2010	Effects of carboxylic acids on the uptake of non-transferrin-bound iron by astrocytes.	Iron	67-71	transferrin	Rattus norvegicus	49-60
20338211-1	2010	The concentrations of non-transferrin-bound iron are elevated in the brain during pathological conditions such as stroke and Alzheimer"s disease.	Iron	44-48	transferrin	Rattus norvegicus	26-37
20593115-7	2010	The genetic variation implicated in iron overload and iron deficiency anaemia, involves mutations in several genes such as HFE, TFR2,HAMP, HJV, Tf and TMPRSS6.	Iron	36-40	transmembrane serine protease 6	Homo sapiens	151-158
20371212-1	2010	Reduced brain iron is strongly associated with restless legs syndrome (RLS).	Iron	14-18	RLS1	Homo sapiens	71-74
20404557-6	2010	In this Addendum, we present a possible scenario that occurs downstream of UBC13, which ultimately leads to Fe deficiency-specific changes in post-embryonic development of Arabidopsis roots.	Iron	108-110	ubiquitin-conjugating enzyme 13	Arabidopsis thaliana	75-80
20432512-1	2010	Human serum transferrin (hTf) is the major iron-binding protein in human plasma, having a vital role in iron transport.	Iron	43-47	transferrin	Homo sapiens	12-23
20432512-1	2010	Human serum transferrin (hTf) is the major iron-binding protein in human plasma, having a vital role in iron transport.	Iron	104-108	transferrin	Homo sapiens	12-23
20387132-0	2010	Pathologic conditions associated with elevated plasma soluble transferrin receptor levels in elderly iron replete anemic patients.	Iron	101-105	transferrin	Homo sapiens	62-73
20371212-2	2010	Oral iron supplements are commonly recommended for RLS but are largely ineffective due to poor absorption and poor tolerability at required doses.	Iron	5-9	RLS1	Homo sapiens	51-54
20371212-4	2010	Surprisingly only a few reports have ever presented data on the clinical effect of high dose intravenous iron for RLS.	Iron	105-109	RLS1	Homo sapiens	114-117
20371212-5	2010	We retrospectively identified 25 subjects (age 53.2+/-11.9, 7 male) that received intravenous iron for RLS refractory to conventional treatments.	Iron	94-98	RLS1	Homo sapiens	103-106
20509117-8	2010	Ferroportin mediates export of iron into the blood where it is bound to transferrin and transported to the macrophages.	Iron	31-35	transferrin	Homo sapiens	72-83
20302570-0	2010	Iron-binding activity of human iron-sulfur cluster assembly protein hIscA1.	Iron	31-35	outer membrane receptor FepA	Escherichia coli	0-4
20188707-0	2010	Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake.	Iron	41-45	CDC42 binding protein kinase alpha	Homo sapiens	6-15
20188707-0	2010	Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake.	Iron	85-89	CDC42 binding protein kinase alpha	Homo sapiens	6-15
20188707-0	2010	Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake.	Iron	85-89	transferrin	Homo sapiens	73-84
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	70-74	CDC42 binding protein kinase alpha	Homo sapiens	20-29
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	70-74	CDC42 binding protein kinase alpha	Homo sapiens	83-92
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	70-74	transferrin	Homo sapiens	110-121
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	70-74	transferrin	Homo sapiens	134-145
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	70-74	CDC42 binding protein kinase alpha	Homo sapiens	83-92
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	293-297	CDC42 binding protein kinase alpha	Homo sapiens	20-29
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	293-297	transferrin	Homo sapiens	110-121
20188707-4	2010	Our results thus indicate that MRCKalpha takes part in Tf-iron uptake, probably via regulation of Tf-TfR endocytosis/endosome trafficking that is dependent on the cellular cytoskeleton.	Iron	58-62	CDC42 binding protein kinase alpha	Homo sapiens	31-40
20188707-5	2010	Regulation of the MRCKalpha activity by intracellular iron levels could thus represent another molecular feedback mechanism cells could use to finely tune iron uptake to actual needs.	Iron	54-58	CDC42 binding protein kinase alpha	Homo sapiens	18-27
20188707-5	2010	Regulation of the MRCKalpha activity by intracellular iron levels could thus represent another molecular feedback mechanism cells could use to finely tune iron uptake to actual needs.	Iron	155-159	CDC42 binding protein kinase alpha	Homo sapiens	18-27
20436681-2	2010	METHODS AND FINDINGS: In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism.	Iron	110-114	iron-sulfur cluster assembly enzyme	Homo sapiens	139-143
20436681-2	2010	METHODS AND FINDINGS: In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism.	Iron	170-174	iron-sulfur cluster assembly enzyme	Homo sapiens	139-143
20436681-2	2010	METHODS AND FINDINGS: In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism.	Iron	170-174	iron-sulfur cluster assembly enzyme	Homo sapiens	139-143
20225831-18	2010	Density functional theory (DFT) calculations, without spin-orbit coupling, reveal that the unpaired electron of the t(2g)(5) ground configuration of the Fe(III) ion occupies the xy orbital, that is, the orbital along the plane perpendicular to the Fe...Gd vector.	Iron	153-155	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	156-159
20178892-0	2010	Tumor necrosis factor-alpha promoter variants and iron phenotypes in 785 hemochromatosis and iron overload screening (HEIRS) study participants.	Iron	93-97	tumor necrosis factor	Homo sapiens	0-27
20178892-1	2010	We sought to determine if TNF promoter variants could explain iron phenotype heterogeneity in adults with previous HFE genotyping.	Iron	62-66	tumor necrosis factor	Homo sapiens	26-29
20307068-5	2010	In this report, the peroxide shunt with both Mn- and Fe-containing heme domain constructs of iNOS(heme) was used to characterize the formation of HNO as the initial inorganic product produced when oxygen activation occurs without pterin radical formation.	Iron	53-55	nitric oxide synthase 2	Homo sapiens	93-97
20404999-9	2010	Our data support the role of frataxin as an iron donor for IscU to form the Fe-S clusters.	Iron	44-48	iron-sulfur cluster assembly enzyme	Homo sapiens	59-63
20404999-9	2010	Our data support the role of frataxin as an iron donor for IscU to form the Fe-S clusters.	Iron	76-80	iron-sulfur cluster assembly enzyme	Homo sapiens	59-63
20405006-1	2010	Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression.	Iron	65-69	iron responsive element binding protein 2	Homo sapiens	35-39
21389518-3	2010	The magnetic scattering effect of Fe is much weaker than that of Mn in MgB2, while it is stronger than that of Ni.	Iron	34-36	secretoglobin family 2A member 1	Homo sapiens	71-75
20079959-1	2010	BACKGROUND: Information about iron stores and their relationship with transferrin saturation (TSAT), serum ferritin, and the erythropoietic response to iron therapy is scarce in anemic non-dialysis-dependent patients with chronic kidney disease (CKD).	Iron	30-34	transferrin	Homo sapiens	70-81
20139087-1	2010	Deletion of two homologous genes, MRS3 and MRS4, that encode mitochondrial iron transporters affects the activity of the vacuolar iron importer Ccc1.	Iron	75-79	Fe(2+) transporter	Saccharomyces cerevisiae S288C	34-38
19838709-5	2010	Patients who had null genotype for both the alleles, i.e., GSTT1/GSTM1 had significantly higher levels of serum iron (P = 0.007) and serum ferritin (P = 0.001) than patients with normal genotype for GST deletions.	Iron	112-116	glutathione S-transferase mu 1	Homo sapiens	65-70
20346225-4	2010	In tumor cells, iron metabolism changes by several mechanisms, such as regulating the growth of tumor cells by transferrin, accelerating the uptake of iron by the overexpressions of transferrin receptors 1 and 2 (TfR1 and TfR2), synthesizing or secreting ferritin by some malignant tumor cells, and upregulating the level of hepcidin in patients with cancer.	Iron	16-20	transferrin	Homo sapiens	111-122
20346225-5	2010	Some advances on diagnosis and treatment based on iron metabolism have been achieved, such as increasing the transfection and target efficiency of transferrin-polyethylenimine (PEI), inducing cell apoptosis by beta-guttiferin through interacting with TfR1.	Iron	50-54	transferrin	Homo sapiens	147-158
20164366-2	2010	Fpn is regulated predominantly by the circulating iron regulatory hormone hepcidin, which binds to cell surface Fpn, initiating its degradation.	Iron	50-54	hepcidin antimicrobial peptide	Rattus norvegicus	74-82
21083463-7	2010	Recently, genome-wide association studies identified common TMPRSS6 variants associated with hematological parameters, suggesting that TMPRSS6 is crucial in the control of iron homeostasis and normal erythropoiesis.	Iron	172-176	transmembrane serine protease 6	Homo sapiens	60-67
21083463-7	2010	Recently, genome-wide association studies identified common TMPRSS6 variants associated with hematological parameters, suggesting that TMPRSS6 is crucial in the control of iron homeostasis and normal erythropoiesis.	Iron	172-176	transmembrane serine protease 6	Homo sapiens	135-142
20123713-7	2010	Two mutants with the most extreme phenotype carry a transposon in a genomic region designated the NIF locus which encodes homologues of SufS and SufU, two proteins presumably involved in [Fe-S] cluster biosynthesis in Gram-positive bacteria.	Iron	188-190	SUFU negative regulator of hedgehog signaling	Homo sapiens	145-149
20299355-5	2010	However, a potassium-rich diet led to &gt;4-fold increases in urinary flows for both groups of mice, although Kcnmb4-deficient mice exhibited less urinary flow, higher plasma potassium concentration, more fluid retention, and significantly lower FE(K) and FE(Na) than wild-type mice despite similar plasma aldosterone levels.	Iron	246-248	potassium large conductance calcium-activated channel, subfamily M, beta member 4	Mus musculus	110-116
19624802-1	2010	The evaluation of iron status in dialysis patients provides information essential to the planning of adequate recombinant human erythropoietin treatment.	Iron	18-22	erythropoietin	Homo sapiens	128-142
20023138-1	2010	The objective of this investigation was to determine associations among rumen endotoxin, plasma serum amyloid A (SAA), and C-reactive protein (CRP) with plasma Ca, Fe, Zn, and Cu in lactating cows challenged with graded amounts of rolled barley grain in the diet (i.e., 0, 15, 30, and 45% of DMI).	Iron	164-166	C-reactive protein	Bos taurus	123-141
20023138-1	2010	The objective of this investigation was to determine associations among rumen endotoxin, plasma serum amyloid A (SAA), and C-reactive protein (CRP) with plasma Ca, Fe, Zn, and Cu in lactating cows challenged with graded amounts of rolled barley grain in the diet (i.e., 0, 15, 30, and 45% of DMI).	Iron	164-166	C-reactive protein	Bos taurus	143-146
20401791-8	2010	HUVEC incubated with glycated protein (GFBS) either alone or combined with iron chelate showed a significant (p &lt; 0.001) elevation of LPO accompanied by depletion of superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased GST activities.	Iron	75-79	catalase	Homo sapiens	191-199
19775690-0	2010	The haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque.	Iron	90-94	haptoglobin	Homo sapiens	4-15
19655216-2	2010	Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1).	Iron	16-20	transferrin	Rattus norvegicus	29-40
20470305-14	2010	These changes are associated with changes in circulating transferrin saturation and ferritin, suggesting improved iron release.	Iron	114-118	transferrin	Homo sapiens	57-68
20067832-9	2010	Loss of MPO activity, possibly through a mechanism involving MPO heme depletion and free iron release, is yet another source of oxidative stress.	Iron	89-93	myeloperoxidase	Homo sapiens	8-11
19997898-4	2010	There is also marked downregulation of ferritin that is required for iron storage and decreased expression of the iron exporter, ferroportin 1, leading to decreased cellular iron efflux.	Iron	114-118	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	129-142
19997898-4	2010	There is also marked downregulation of ferritin that is required for iron storage and decreased expression of the iron exporter, ferroportin 1, leading to decreased cellular iron efflux.	Iron	114-118	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	129-142
19997898-5	2010	The increased mitochondrial iron uptake is facilitated by upregulation of the mitochondrial iron transporter, mitoferrin 2.	Iron	28-32	solute carrier family 25, member 28	Mus musculus	110-122
19997898-5	2010	The increased mitochondrial iron uptake is facilitated by upregulation of the mitochondrial iron transporter, mitoferrin 2.	Iron	92-96	solute carrier family 25, member 28	Mus musculus	110-122
20006850-1	2010	Pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS), is an autosomal recessive neurodegenerative disorder characterized by iron accumulation in the brain.	Iron	180-184	pantothenate kinase 2	Homo sapiens	0-48
20006850-1	2010	Pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS), is an autosomal recessive neurodegenerative disorder characterized by iron accumulation in the brain.	Iron	180-184	pantothenate kinase 2	Homo sapiens	50-54
20032114-15	2010	We conclude that 1) Fe/glycerol-induced tubular injury causes sustained proinflammatory gene activation, 2) decreasing HO-1 expression, as reflected by mRNA levels, may facilitate this proinflammatory state, and 3) gene-activating histone modifications are early injury events and progressively increase at selected proinflammatory genes.	Iron	20-22	heme oxygenase 1	Mus musculus	119-123
19861159-10	2010	NO dependent HIF-1alpha accumulation under normoxia was due to direct inhibition of PHDs and FIH-1 most likely by competitive binding of NO to the ferrous iron in the catalytically active center of the enzymes.	Iron	155-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
19892014-6	2010	While Fes was not required for SCF-induced signaling to Akt and Erk kinases, Fes-deficient (fes-/-) BMMCs displayed a defect in sustained p38 kinase activation, compared to control cells.	Iron	77-80	mitogen-activated protein kinase 14	Homo sapiens	138-141
19861159-12	2010	Three major mechanisms are discussed to be involved in enhancing the PHD activity despite the lack of oxygen: (1) NO mediated induction of a HIF-1 dependent feedback loop leading to newly expressed PHD2 and enhanced nuclear localization, (2) O2-redistribution towards PHDs after inhibition of mitochondrial respiration by NO, (3) reactivation of PHD activity by a NO mediated increase of iron and 2-oxoglutarate and/or involvement of reactive oxygen and/or nitrogen species.	Iron	388-392	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-146
19892014-7	2010	SCF-treated Fes-deficient BMMCs also displayed elevated beta1 integrin-mediated cell adhesion and spreading on fibronectin, compared to control cells, and a reduction in cell polarization at later times of SCF treatment.	Iron	12-15	fibronectin 1	Homo sapiens	111-122
20164305-1	2010	Endosomal recycling of the mammalian iron transporter DMT1 is assumed to be important for efficient and rapid uptake of iron across the endosomal membrane in the transferrin cycle.	Iron	37-41	charged multivesicular body protein 2B	Homo sapiens	54-58
19892014-10	2010	Overall, these results implicate Fes in regulating cross-talk between Kit and beta1 integrins to promote cytoskeletal reorganization and motility of mast cells.	Iron	33-36	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-73
19892014-10	2010	Overall, these results implicate Fes in regulating cross-talk between Kit and beta1 integrins to promote cytoskeletal reorganization and motility of mast cells.	Iron	33-36	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	78-83
21151827-4	2010	The affinity of the ruthenium complex for holo-transferrin was higher than for the apo-form suggesting a cooperative iron-mediated metal binding mechanism.	Iron	117-121	transferrin	Homo sapiens	47-58
20039303-1	2010	Iron metabolism in inflammation has been mostly characterized in macrophages exposed to pathogens or inflammatory conditions, mimicked by the combined action of LPS and IFN-gamma (M1 polarization).	Iron	0-4	interferon gamma	Homo sapiens	169-178
20228941-3	2010	Unlike traditional flame methods, this configuration allows for the iron particle formation to be maintained in a more reducing environment.	Iron	68-72	CASP8 and FADD like apoptosis regulator	Homo sapiens	19-24
20164305-1	2010	Endosomal recycling of the mammalian iron transporter DMT1 is assumed to be important for efficient and rapid uptake of iron across the endosomal membrane in the transferrin cycle.	Iron	37-41	transferrin	Homo sapiens	162-173
20470276-9	2010	Iron induced significant increase in plasma malondialdehyde and IL-8 in monocytes, but had no effect on total antioxidant capacity, CD11b/CD18 expression, plasma IL-8, vWF and sICAM-1.	Iron	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
19906658-1	2010	BACKGROUND: An optimal haemoglobin (Hb) response to erythropoietin requires elevated iron indices in dialysis patients; however, it is unknown if the same applies in chronic kidney disease (CKD).	Iron	85-89	erythropoietin	Homo sapiens	52-66
20023006-0	2010	Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-166
20023006-0	2010	Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53.	Iron	0-4	tumor protein p53	Homo sapiens	171-174
20023006-0	2010	Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53.	Iron	79-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-166
20023006-0	2010	Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53.	Iron	79-83	tumor protein p53	Homo sapiens	171-174
20023006-5	2010	Apart from iron-mediated regulation of expression via hypoxia inducible factor-1 alpha, it was noteworthy that the transcription factor p53 was also involved in iron-regulated gene expression.	Iron	11-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-86
20023006-5	2010	Apart from iron-mediated regulation of expression via hypoxia inducible factor-1 alpha, it was noteworthy that the transcription factor p53 was also involved in iron-regulated gene expression.	Iron	11-15	tumor protein p53	Homo sapiens	136-139
19969068-4	2010	Incubation for 24 h with Fe-NTA (20-40 microM) or the nitric oxide donor Delta-nonoate increased iNOS mRNA but decreased iNOS protein levels; under these conditions, iron stimulated the activity and the dimerization of iNOS.	Iron	166-170	nitric oxide synthase 2	Homo sapiens	97-101
20117079-4	2010	We report here that FES interacts with KIT and is phosphorylated following activation by its ligand SCF.	Iron	20-23	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	39-42
19969068-4	2010	Incubation for 24 h with Fe-NTA (20-40 microM) or the nitric oxide donor Delta-nonoate increased iNOS mRNA but decreased iNOS protein levels; under these conditions, iron stimulated the activity and the dimerization of iNOS.	Iron	166-170	nitric oxide synthase 2	Homo sapiens	121-125
19969068-4	2010	Incubation for 24 h with Fe-NTA (20-40 microM) or the nitric oxide donor Delta-nonoate increased iNOS mRNA but decreased iNOS protein levels; under these conditions, iron stimulated the activity and the dimerization of iNOS.	Iron	166-170	nitric oxide synthase 2	Homo sapiens	121-125
19969068-7	2010	Inhibition of iNOS activity with 1400 W enhanced iron-induced ROS generation and prevented both iron-dependent cardiomyocyte hypertrophy and cardioprotection.	Iron	49-53	nitric oxide synthase 2	Homo sapiens	14-18
19969068-7	2010	Inhibition of iNOS activity with 1400 W enhanced iron-induced ROS generation and prevented both iron-dependent cardiomyocyte hypertrophy and cardioprotection.	Iron	96-100	nitric oxide synthase 2	Homo sapiens	14-18
19926817-7	2010	However, in Nrf2-null mice fed an MCD diet, the pathological state of the steatohepatitis was aggravated in terms of fatty changes, inflammation, fibrosis, and iron accumulation.	Iron	160-164	nuclear factor, erythroid derived 2, like 2	Mus musculus	12-16
19917294-0	2010	The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pH.	Iron	23-27	transferrin	Homo sapiens	41-52
19917294-2	2010	Human serum transferrin (hTF) carries one iron in each of two similar lobes.	Iron	42-46	transferrin	Homo sapiens	12-23
20045320-4	2010	Molecular modeling studies showed that the N-difluoromethyl-1,2-dihydropyridin-2-one moiety present in 9a inserts into the secondary pocket present in COX-2 to confer COX-2 selectivity, and that the N-difluoromethyl-1,2-dihydropyrid-2-one group (9a) binds close to the region of the 15-LOX enzyme containing catalytic iron (His361, His366).	Iron	318-322	prostaglandin-endoperoxide synthase 2	Homo sapiens	151-156
20019189-0	2010	Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis.	Iron	0-4	tumor protein p53	Homo sapiens	45-48
20019189-4	2010	Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis.	Iron	0-4	tumor protein p53	Homo sapiens	34-37
20019189-4	2010	Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis.	Iron	0-4	tumor protein p53	Homo sapiens	177-180
20019189-4	2010	Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis.	Iron	99-103	tumor protein p53	Homo sapiens	34-37
20019189-5	2010	Iron status influenced p53 ubiquitination and degradation rate, and the MDM2 inhibitor nutlin increased p53 levels in iron-depleted cells.	Iron	0-4	tumor protein p53	Homo sapiens	23-26
20019189-5	2010	Iron status influenced p53 ubiquitination and degradation rate, and the MDM2 inhibitor nutlin increased p53 levels in iron-depleted cells.	Iron	118-122	tumor protein p53	Homo sapiens	104-107
20019189-7	2010	The MDM2 -309T &gt; G promoter polymorphism, determining increased MDM2 and lower p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma.	Iron	315-319	tumor protein p53	Homo sapiens	82-85
20019189-8	2010	In conclusion, iron status influences p53 activity and antioxidant response by modulating MDM2 expression.	Iron	15-19	tumor protein p53	Homo sapiens	38-41
19837190-10	2010	Finally we briefly introduce a metal insertion system of SOD, focusing particularly on the iron misincorporation of nSOD, as a part of post-translational modifications.	Iron	91-95	superoxide dismutase 1	Homo sapiens	57-60
19766747-3	2010	Fine mapping of a syntenic segment on Xp22 in a Caucasian female population suggested a moderate association between lumbar spine (LS) BMD and 2 intronic SNPs in the Pirin (PIR) gene, which encodes an iron-binding nuclear protein.	Iron	201-205	pirin	Homo sapiens	166-171
19766747-3	2010	Fine mapping of a syntenic segment on Xp22 in a Caucasian female population suggested a moderate association between lumbar spine (LS) BMD and 2 intronic SNPs in the Pirin (PIR) gene, which encodes an iron-binding nuclear protein.	Iron	201-205	pirin	Homo sapiens	173-176
19911117-1	2010	Zinc, copper, and iron aggregate Abeta and accumulate in Alzheimer"s disease (AD) plaques.	Iron	18-22	amyloid beta precursor protein	Homo sapiens	33-38
19918259-4	2010	Here, we show that, lactoferrin (LTF), a pleiotropic 80-kDa glycoprotein with iron-binding properties, acts as a powerful inhibitor of eosinophil migration.	Iron	78-82	lactotransferrin	Homo sapiens	20-31
20179792-2	2010	Iron overload is suggested by elevations in serum ferritin and transferrin saturation.	Iron	0-4	transferrin	Homo sapiens	63-74
19923256-9	2010	Although the CYP2J2 active site can accommodate large substrates, it may be more narrow than CYP3A4, limiting metabolism to moieties that can extend closer toward the active heme iron.	Iron	179-183	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99
20050877-1	2010	BACKGROUND: Iron overload may contribute to the pathogenesis of insulin resistance.	Iron	12-16	insulin	Homo sapiens	64-71
19838638-13	2010	The decrease in FE(NO) after aminoguanidine and subsequent partial reversal by L-arginine in both groups, suggests that Type II NOS contributes to the FE(NO) in both.	Iron	16-18	nitric oxide synthase 2	Homo sapiens	120-131
19918259-4	2010	Here, we show that, lactoferrin (LTF), a pleiotropic 80-kDa glycoprotein with iron-binding properties, acts as a powerful inhibitor of eosinophil migration.	Iron	78-82	lactotransferrin	Homo sapiens	33-36
20099321-5	2010	R(2) values in high-iron gray matter regions were significantly correlated (positively) with liver iron concentrations (globus pallidus, ventral pallidum) and serum transferrin saturation (caudate nucleus, globus pallidus, putamen) measured concurrently with brain R(2), and with serum iron concentrations (caudate nucleus, globus pallidus) measured three years before the current study.	Iron	20-24	transferrin	Homo sapiens	165-176
19834746-2	2010	Glx2-2-containing fractions that were purple, yellow, or colorless were separated during purification, and the differently colored fractions were found to contain different amounts of Fe and Zn(II).	Iron	184-186	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	0-6
20091060-2	2010	Hepcidin, mainly produced by hepatocytes in a STAT3- and/or SMAD-dependent manner, is involved in iron homeostasis.	Iron	98-102	signal transducer and activator of transcription 3	Mus musculus	46-51
20148270-7	2010	CONCLUSIONS: The diagnostic plot was superior to transferrin saturation and ferritin in predicting iron availability in hypochromic patients treated with ESAs and proved useful to select treatment for anaemia in cancer patients.	Iron	99-103	transferrin	Homo sapiens	49-60
19950335-3	2010	Actinides in plasma are assumed to be mainly complexed to transferrin, the iron carrier protein.	Iron	75-79	transferrin	Homo sapiens	58-69
19900513-4	2010	Since macrophages, containing large amounts of lysosomal iron, are very resistant to TNF-alpha, we hypothesized that this cell type has developed specific defense mechanisms against TNF-alpha-induced ROS generation.	Iron	57-61	tumor necrosis factor	Mus musculus	182-191
19900513-7	2010	In contrast, TNF-alpha stabilized lysosomes and protected cells, particularly those iron-exposed, by reducing cellular iron and increasing H-ferritin.	Iron	84-88	tumor necrosis factor	Mus musculus	13-22
19900513-7	2010	In contrast, TNF-alpha stabilized lysosomes and protected cells, particularly those iron-exposed, by reducing cellular iron and increasing H-ferritin.	Iron	119-123	tumor necrosis factor	Mus musculus	13-22
19950335-10	2010	EXAFS data at the actinide edge have allowed a structural model of the actinide binding site to be elaborated: at least one tyrosine residue could participate in the actinide coordination sphere (two for iron), forming a mixed hydroxo-transferrin complex in which actinides are bound with transferrin both through An-tyrosine and through An--OH bonds.	Iron	204-208	transferrin	Homo sapiens	235-246
19950335-10	2010	EXAFS data at the actinide edge have allowed a structural model of the actinide binding site to be elaborated: at least one tyrosine residue could participate in the actinide coordination sphere (two for iron), forming a mixed hydroxo-transferrin complex in which actinides are bound with transferrin both through An-tyrosine and through An--OH bonds.	Iron	204-208	transferrin	Homo sapiens	289-300
19880490-3	2010	The single-nucleotide polymorphism most strongly associated with lower serum iron concentration was rs4820268 (P = 5.12 x 10(-9)), located in exon 13 of the transmembrane protease serine 6 (TMPRSS6) gene, an enzyme that promotes iron absorption and recycling by inhibiting hepcidin antimicrobial peptide transcription.	Iron	77-81	transmembrane serine protease 6	Homo sapiens	157-188
19800271-3	2010	The mutation results in a loss of post-transcriptional negative feedback exerted by the interaction between iron regulatory proteins 1, 2 (IRP1 and IRP2) and IRE, which leads to uncontrolled expression of L-ferritin.	Iron	108-112	iron responsive element binding protein 2	Homo sapiens	148-152
20014828-6	2010	When dilute As(V) was coprecipitated with ferrihydrite at pH 5 and 7, it was primarily adsorbed as a surface complex when the initial molar ratio was As/Fe &lt; 0.4, while a ferric arsenate and surface complex was formed when this ratio was &gt;or= 0.4.	Iron	153-155	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	12-17
19880490-5	2010	Our results confirm the association of TMPRSS6 variants with iron level and provide further evidence of association with other anemia-related phenotypes.	Iron	61-65	transmembrane serine protease 6	Homo sapiens	39-46
19748730-0	2010	Characterization of sodium dodecyl sulfate modified iron pillared montmorillonite and its application for the removal of aqueous Cu(II) and Co(II).	Iron	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
19880490-3	2010	The single-nucleotide polymorphism most strongly associated with lower serum iron concentration was rs4820268 (P = 5.12 x 10(-9)), located in exon 13 of the transmembrane protease serine 6 (TMPRSS6) gene, an enzyme that promotes iron absorption and recycling by inhibiting hepcidin antimicrobial peptide transcription.	Iron	77-81	transmembrane serine protease 6	Homo sapiens	190-197
19880490-3	2010	The single-nucleotide polymorphism most strongly associated with lower serum iron concentration was rs4820268 (P = 5.12 x 10(-9)), located in exon 13 of the transmembrane protease serine 6 (TMPRSS6) gene, an enzyme that promotes iron absorption and recycling by inhibiting hepcidin antimicrobial peptide transcription.	Iron	229-233	transmembrane serine protease 6	Homo sapiens	157-188
19880490-3	2010	The single-nucleotide polymorphism most strongly associated with lower serum iron concentration was rs4820268 (P = 5.12 x 10(-9)), located in exon 13 of the transmembrane protease serine 6 (TMPRSS6) gene, an enzyme that promotes iron absorption and recycling by inhibiting hepcidin antimicrobial peptide transcription.	Iron	229-233	transmembrane serine protease 6	Homo sapiens	190-197
20862391-7	2010	GLRX5 may also provide Fe-S cofactor for ferrochelatase, the last enzyme in heme synthesis.	Iron	23-25	ferrochelatase	Danio rerio	41-55
21565772-3	2010	Cadmium and iron content of leaves developing under the stress was in the order of cCad &gt; eCad &gt; cFedef + Cad and cCad   eFedef   cFedef + Cad &lt; eCad &lt; cFedef, respectively.	Iron	12-16	cadherin 1	Homo sapiens	93-97
21565772-3	2010	Cadmium and iron content of leaves developing under the stress was in the order of cCad &gt; eCad &gt; cFedef + Cad and cCad   eFedef   cFedef + Cad &lt; eCad &lt; cFedef, respectively.	Iron	12-16	cadherin 1	Homo sapiens	154-158
19917753-3	2010	growing in broth culture or within human macrophages can acquire Fe from the two major host Fe-binding proteins, lactoferrin (Lf) and transferrin (Tf).	Iron	65-67	transferrin	Homo sapiens	134-145
20015002-4	2010	Recently, matriptase-2 has been functionally linked to the regulation of iron metabolism; however, there is also evidence to suggest that, as with other members of the TTSPs, matriptase-2 may have a role in cancer development and progression.	Iron	73-77	transmembrane serine protease 6	Homo sapiens	10-22
19917753-3	2010	growing in broth culture or within human macrophages can acquire Fe from the two major host Fe-binding proteins, lactoferrin (Lf) and transferrin (Tf).	Iron	65-67	transferrin	Homo sapiens	147-149
21147712-0	2010	A combination of iron and retinol supplementation benefits iron status, IL-2 level and lymphocyte proliferation in anemic pregnant women.	Iron	17-21	interleukin 2	Homo sapiens	72-76
20648931-19	2010	iron over oral iron is that it may bypass hepcidin actions by directly loading transferrin and making iron available to macrophages.	Iron	0-4	transferrin	Homo sapiens	79-90
20648931-19	2010	iron over oral iron is that it may bypass hepcidin actions by directly loading transferrin and making iron available to macrophages.	Iron	15-19	transferrin	Homo sapiens	79-90
20648931-19	2010	iron over oral iron is that it may bypass hepcidin actions by directly loading transferrin and making iron available to macrophages.	Iron	15-19	transferrin	Homo sapiens	79-90
21147712-2	2010	OBJECTIVE: to investigate the effect of iron combined with retinol supplementation on iron status, IL-2 level and lymphocyte proliferation.	Iron	40-44	interleukin 2	Homo sapiens	99-103
20185911-4	2010	To investigate the relationship of iron with MDR and early growth response gene-1 (EGR1), we investigated the effect of iron deprivation on expression and/or function of multidrug resistance-1 (MDR1), early growth response gene-1 (EGR1), ferritin heavy chain gene (H-Fn) and MDR1-encoded P-glycoprotein (P-gp) in the K562 leukemic cell line.	Iron	120-124	ATP binding cassette subfamily B member 1	Homo sapiens	170-192
20139607-2	2010	It binds iron ions in the blood serum and delivers them into target cells via transferrin receptor.	Iron	9-13	transferrin	Homo sapiens	78-89
20139607-7	2010	Consequently, the recombinant product had an iron binding function just as the serum specimen has: two Fe(3+) sites existed in a recombinant transferrin molecule, as estimated by titration analysis using visible absorption, fluorescence spectra, and electrophoretic behavior in urea denaturing polyacrylamide gel electrophoresis (PAGE).	Iron	45-49	transferrin	Homo sapiens	141-152
20185911-10	2010	CONCLUSIONS: These results suggest a close relationship between iron deprivation and reduced MDR1/P-gp expression and function.	Iron	64-68	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
20185911-10	2010	CONCLUSIONS: These results suggest a close relationship between iron deprivation and reduced MDR1/P-gp expression and function.	Iron	64-68	ATP binding cassette subfamily B member 1	Homo sapiens	98-102
21525761-8	2010	In conclusion, MnSOD overexpression prevents mtDNA depletion after an acute alcohol binge but aggravates this effect after prolonged alcohol consumption, which selectively triggers iron accumulation in TgMnSOD(+++) mice but not in WT mice.	Iron	181-185	superoxide dismutase 2, mitochondrial	Mus musculus	15-20
23496110-4	2010	The liver is the major storage organ for iron and produces transferrin and hepcidin, which help to regulate iron.	Iron	108-112	transferrin	Homo sapiens	59-70
21088424-5	2010	Multiple pregnancies and iron intake during pregnancy were significantly associated with RLS during the third trimester.	Iron	25-29	RLS1	Homo sapiens	89-92
19732137-0	2010	Non-transferrin-bound labile plasma iron and iron overload in sickle-cell disease: a comparative study between sickle-cell disease and beta-thalassemic patients.	Iron	36-40	transferrin	Homo sapiens	4-15
19744128-0	2010	Elevated serum parathormone levels are associated with myocardial iron overload in patients with beta-thalassaemia major.	Iron	66-70	parathyroid hormone	Homo sapiens	15-27
19744128-8	2010	Multivariant regression analysis identified PTH levels as the major predictor of increased myocardial iron.	Iron	102-106	parathyroid hormone	Homo sapiens	44-47
19786029-8	2010	Furthermore, iron-supplemented diet induced a compensatory up-regulation of BMP2, BMP4, and BMP9 in the small intestine of BMP6(-/-) mice that was apparently not sufficient to assure iron homeostasis.	Iron	13-17	bone morphogenetic protein 2	Mus musculus	76-80
19786029-8	2010	Furthermore, iron-supplemented diet induced a compensatory up-regulation of BMP2, BMP4, and BMP9 in the small intestine of BMP6(-/-) mice that was apparently not sufficient to assure iron homeostasis.	Iron	13-17	bone morphogenetic protein 4	Mus musculus	82-86
19820086-0	2010	Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin.	Iron	77-81	transferrin	Homo sapiens	122-133
20157260-0	2010	Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.	Iron	21-25	histocompatibility 2, class II antigen A, beta 1	Mus musculus	82-89
21327119-2	2010	Here, I provide commentary on one of those papers, "Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice", which was published in the Journal of Clinical Investigation in November, 2009.	Iron	125-129	toll-like receptor 4	Mus musculus	76-80
21327119-3	2010	It describes experiments that point to a previously unappreciated role for intracellular iron in the regulation of Toll-like receptor 4 signaling, and also demonstrates the potential therapeutic application of this information in a novel anti-inflammatory strategy based on manipulating iron balance.	Iron	89-93	toll-like receptor 4	Mus musculus	115-135
21327119-3	2010	It describes experiments that point to a previously unappreciated role for intracellular iron in the regulation of Toll-like receptor 4 signaling, and also demonstrates the potential therapeutic application of this information in a novel anti-inflammatory strategy based on manipulating iron balance.	Iron	287-291	toll-like receptor 4	Mus musculus	115-135
19820086-7	2010	We also analyzed the transferrin-catecholamine interactions in human serum and found that therapeutically relevant concentrations of stress hormones and inotropes could directly affect the iron binding of serum-transferrin so that the normally highly bacteriostatic tissue fluid became significantly more supportive of the growth of bacteria.	Iron	189-193	transferrin	Homo sapiens	21-32
19820086-2	2010	A major element of the growth induction process has been shown to involve the catecholamines binding to the high-affinity ferric-iron-binding proteins transferrin (Tf) and lactoferrin, which then enables bacterial acquisition of normally inaccessible sequestered host iron.	Iron	129-133	transferrin	Homo sapiens	151-162
19820086-7	2010	We also analyzed the transferrin-catecholamine interactions in human serum and found that therapeutically relevant concentrations of stress hormones and inotropes could directly affect the iron binding of serum-transferrin so that the normally highly bacteriostatic tissue fluid became significantly more supportive of the growth of bacteria.	Iron	189-193	transferrin	Homo sapiens	211-222
19897659-1	2010	The Mtr respiratory pathway of Shewanella oneidensis strain MR-1 is required to effectively respire both soluble and insoluble forms of oxidized iron.	Iron	145-149	tryptophan permease	Shewanella oneidensis MR-1	4-7
19820086-2	2010	A major element of the growth induction process has been shown to involve the catecholamines binding to the high-affinity ferric-iron-binding proteins transferrin (Tf) and lactoferrin, which then enables bacterial acquisition of normally inaccessible sequestered host iron.	Iron	129-133	transferrin	Homo sapiens	164-166
19820086-4	2010	The present study employed electron paramagnetic resonance spectroscopy and chemical iron-binding analyses to demonstrate that catecholamine stress hormones form direct complexes with the ferric iron within transferrin and lactoferrin.	Iron	85-89	transferrin	Homo sapiens	207-218
20390867-0	2010	Environmental factors influencing remediation of TNT-contaminated water and soil with nanoscale zero-valent iron particles.	Iron	3-7	chromosome 16 open reading frame 82	Homo sapiens	49-52
20182641-1	2010	We have reported three Fe-deficiency-responsive elements (FEREs), FOX1, ATX1, and FEA1, all of which are positive regulatory elements in response to iron deficiency in Chlamydomonas reinhardtii.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	72-76
20390867-1	2010	This study evaluated the application of nanoscale metallic particles (nanoscale zero-valent iron (nZVI) particles) in the remediation of TNT in contaminated water and soil samples.	Iron	92-96	chromosome 16 open reading frame 82	Homo sapiens	137-140
20122582-9	2010	TNF(DeltaARE/+) mice significantly increase their (59)Fe-content in inflamed joints and ilea, and correspondingly reduce splenic (59)Fe-content.	Iron	54-56	tumor necrosis factor	Mus musculus	0-3
20352824-6	2010	In the results, MgO and Fe were impurity which may affect superconducting properties of MgB2 samples, and it"s distribution could be confirmed from EDS mapping result.	Iron	24-26	secretoglobin family 2A member 1	Homo sapiens	88-92
19780883-8	2010	During the iron reduction therapy, the plasma levels of tHODE but not t8-iso-PGF(2alpha) decreased and inversely its stereo-isomer ratio (ZE/EE) increased in parallel with the decreases of serum alanine aminotransferase, ferritin and alpha-fetoprotein.	Iron	11-15	alpha fetoprotein	Homo sapiens	234-251
20122582-9	2010	TNF(DeltaARE/+) mice significantly increase their (59)Fe-content in inflamed joints and ilea, and correspondingly reduce splenic (59)Fe-content.	Iron	133-135	tumor necrosis factor	Mus musculus	0-3
20122582-0	2010	Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation.	Iron	0-4	tumor necrosis factor	Mus musculus	36-39
20122582-12	2010	In conclusion, erythropoiesis in inflamed TNF(DeltaARE/+) mice could be iron-limited due to losses with exfoliated iron-loaded enterocytes and/or to increased iron-retention in RES cells that shift from the spleen to inflamed tissues.	Iron	72-76	tumor necrosis factor	Mus musculus	42-45
20122582-7	2010	Duodenal (59)Fe-retention was increased in TNF(DeltaARE/+) mice, suggesting higher (59)Fe-losses with defoliated enterocytes.	Iron	13-15	tumor necrosis factor	Mus musculus	43-46
20122582-7	2010	Duodenal (59)Fe-retention was increased in TNF(DeltaARE/+) mice, suggesting higher (59)Fe-losses with defoliated enterocytes.	Iron	87-89	tumor necrosis factor	Mus musculus	43-46
20122582-12	2010	In conclusion, erythropoiesis in inflamed TNF(DeltaARE/+) mice could be iron-limited due to losses with exfoliated iron-loaded enterocytes and/or to increased iron-retention in RES cells that shift from the spleen to inflamed tissues.	Iron	115-119	tumor necrosis factor	Mus musculus	42-45
20122582-12	2010	In conclusion, erythropoiesis in inflamed TNF(DeltaARE/+) mice could be iron-limited due to losses with exfoliated iron-loaded enterocytes and/or to increased iron-retention in RES cells that shift from the spleen to inflamed tissues.	Iron	115-119	tumor necrosis factor	Mus musculus	42-45
20391109-10	2010	BALF Fe-binding capacity was decreased in SHHF relative to WKY rats and was associated with increased transferrin (Trf) and ferritin.	Iron	5-7	transferrin	Rattus norvegicus	102-113
20391109-10	2010	BALF Fe-binding capacity was decreased in SHHF relative to WKY rats and was associated with increased transferrin (Trf) and ferritin.	Iron	5-7	transferrin	Rattus norvegicus	115-118
19939449-0	2010	Macrophage-inflammatory protein-3alpha/CCL-20 is transcriptionally induced by the iron chelator desferrioxamine in human mononuclear phagocytes through nuclear factor (NF)-kappaB.	Iron	82-86	nuclear factor kappa B subunit 1	Homo sapiens	152-178
21246919-1	2010	INTRODUCTION: Secondary lack of iron in patients on hemodyalisis is the main cause of inadequate answer on therapy of recombinant human erythropoietin (rHuEPO).	Iron	32-36	erythropoietin	Homo sapiens	136-150
20075442-0	2010	[Evaluation of iron status by serum transferrin receptor level].	Iron	15-19	transferrin	Homo sapiens	36-47
21246919-13	2010	If we would use criterias like the saturation transferrin and the level of ferritin as referent standard we would have 26/53 (49.1%) patients with iron deficiency in the whole sample.	Iron	147-151	transferrin	Homo sapiens	46-57
20619018-2	2010	These defects are located in genes that encode for the cellular iron importing protein Divalent Metal Transporter 1 (DMT1), the iron exporting protein ferroportin, the mitochondrial enzyme glutaredoxin-5 and the hepatocyte membrane protein matriptase-2.	Iron	64-68	transmembrane serine protease 6	Homo sapiens	240-252
20719010-0	2010	[Iron deficiency anaemia due to a matriptase-2 mutation].	Iron	1-5	transmembrane serine protease 6	Homo sapiens	34-46
20719010-8	2010	Therefore, patients with matriptase-2 deficiency respond poorly to oral iron treatment and have to be treated with intravenous iron.	Iron	72-76	transmembrane serine protease 6	Homo sapiens	25-37
20719010-8	2010	Therefore, patients with matriptase-2 deficiency respond poorly to oral iron treatment and have to be treated with intravenous iron.	Iron	127-131	transmembrane serine protease 6	Homo sapiens	25-37
20647390-3	2010	iron improves the efficacy of recombinant human erythropoietin (rHuEPO) in anemic cancer patients undergoing chemotherapy.	Iron	0-4	erythropoietin	Homo sapiens	48-62
20185936-8	2010	CONCLUSIONS: Redox-active iron and copper in pleural fluid and saliva, upon encounter with CS, may be responsible for this carcinogenesis, mediated via alteration of p53 function.	Iron	26-30	tumor protein p53	Homo sapiens	166-169
20055961-5	2010	Expression of AtIRT1, AtFRO2, AtFIT1 and AtFER1 was up-regulated by CO exposure in iron-deficient seedlings.	Iron	83-87	FER-like regulator of iron uptake	Arabidopsis thaliana	30-36
20055961-5	2010	Expression of AtIRT1, AtFRO2, AtFIT1 and AtFER1 was up-regulated by CO exposure in iron-deficient seedlings.	Iron	83-87	ferretin 1	Arabidopsis thaliana	41-47
19898848-9	2010	However, in iron-free medium, Vit C significantly improved recovery.	Iron	12-16	vitrin	Homo sapiens	30-33
20041757-4	2010	For human cells irradiated with iron ions, cell survival was decreased, and in p53 mutant cells, the levels of mutagenesis were increased when HRR was impaired.	Iron	32-36	tumor protein p53	Homo sapiens	79-82
19940280-0	2010	Sex-specific role of thioredoxin in neuroprotection against iron-induced brain injury conferred by estradiol.	Iron	60-64	thioredoxin 1	Rattus norvegicus	21-32
19828447-2	2009	To identify new regulators of iron homeostasis, a luciferase-based genetic screen using the Arabidopsis AtFer1 ferritin promoter as a target was developed.	Iron	30-34	ferretin 1	Arabidopsis thaliana	104-110
22013282-3	2010	However, because transferrin provides iron to tumor cells in animals, chelators have not been effective antitumor agents.	Iron	38-42	transferrin	Homo sapiens	17-28
19828447-5	2009	Mutants in the TIC gene exhibited a chlorotic phenotype rescued by exogenous iron addition and are hypersensitive to iron during the early stages of development.	Iron	77-81	time for coffee	Arabidopsis thaliana	15-18
19828447-5	2009	Mutants in the TIC gene exhibited a chlorotic phenotype rescued by exogenous iron addition and are hypersensitive to iron during the early stages of development.	Iron	117-121	time for coffee	Arabidopsis thaliana	15-18
19828447-6	2009	We showed that iron overload-responsive genes are regulated by TIC and by the central oscillator of the circadian clock.	Iron	15-19	time for coffee	Arabidopsis thaliana	63-66
19828447-7	2009	TIC represses their expression under low iron conditions, and its activity requires light and light/dark cycles.	Iron	41-45	time for coffee	Arabidopsis thaliana	0-3
19828447-8	2009	Regarding AtFer1, this repression is independent of the previously characterized cis-acting element iron-dependent regulatory sequence, known to be involved in AtFer1 repression.	Iron	100-104	ferretin 1	Arabidopsis thaliana	160-166
20028528-9	2009	Exposure of A. baumannii SMAL to subinhibitory concentrations of imipenem resulted in biofilm stimulation and increased production of iron uptake proteins.	Iron	134-138	SMAL	Homo sapiens	25-29
20028528-10	2009	Growth in iron-supplemented medium also stimulated surface adhesion, thus suggesting that increased intracellular iron concentrations might act as an environmental signal for biofilm formation in A. baumannii SMAL.	Iron	10-14	SMAL	Homo sapiens	209-213
19828447-9	2009	These results showed that the regulation of iron homeostasis in plants is a major output of the TIC- and central oscillator-dependent signaling pathways.	Iron	44-48	time for coffee	Arabidopsis thaliana	96-99
20028528-10	2009	Growth in iron-supplemented medium also stimulated surface adhesion, thus suggesting that increased intracellular iron concentrations might act as an environmental signal for biofilm formation in A. baumannii SMAL.	Iron	114-118	SMAL	Homo sapiens	209-213
19877000-2	2009	Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD pathology: 1) aggregation of the peptide amyloid-beta (Abeta), and 2) production of reactive oxygen species (ROS) induced by Abeta.	Iron	11-13	amyloid beta precursor protein	Homo sapiens	121-140
20064440-0	2009	In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.	Iron	33-37	glutaredoxin 2	Homo sapiens	68-72
19877000-2	2009	Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD pathology: 1) aggregation of the peptide amyloid-beta (Abeta), and 2) production of reactive oxygen species (ROS) induced by Abeta.	Iron	11-13	amyloid beta precursor protein	Homo sapiens	127-132
19679638-3	2009	Recent studies have shown that bivalent metals such as iron, copper, and zinc are involved in APP expression, Abeta deposition, and senile plaque formation in the AD brain.	Iron	55-59	amyloid beta precursor protein	Homo sapiens	110-115
19828835-9	2009	At 5 microM transferrin, iron uptake was not affected by combined TFR1 and TFR2 knockdown.	Iron	25-29	transferrin	Homo sapiens	12-23
19764989-1	2009	Labile plasma iron (LPI), a non-transferrin-bound component of plasma iron detected in iron overload disorders is a potential source of cellular iron accumulation and ensuing oxidative damage.	Iron	14-18	transferrin	Homo sapiens	32-43
19729006-9	2009	The quercetin-induced increase and nuclear translocation of HIF-1alpha was reversed by addition of excess iron (100 microM).	Iron	106-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
19828835-0	2009	The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.	Iron	62-66	transferrin	Homo sapiens	12-23
19828835-2	2009	The aims of this study were to 1) determine the relative importance of TFR1 and TFR2 in transferrin-bound iron (TBI) uptake by HuH7 human hepatoma cells and 2) characterize the role of metal-transferrin complexes in the regulation of these receptors.	Iron	106-110	transferrin	Homo sapiens	88-99
19552907-7	2009	Incubation of macrophages (J774, THP-1 and MPM) with Fe/ascorbate ion, attenuated apoA-1 and HDL(3)-mediated cholesterol efflux whereas resveratrol (0-25microM) significantly redressed this attenuation in a dose-dependent manner (p&lt;0.001).	Iron	53-55	GLI family zinc finger 2	Homo sapiens	33-38
19552907-7	2009	Incubation of macrophages (J774, THP-1 and MPM) with Fe/ascorbate ion, attenuated apoA-1 and HDL(3)-mediated cholesterol efflux whereas resveratrol (0-25microM) significantly redressed this attenuation in a dose-dependent manner (p&lt;0.001).	Iron	53-55	apolipoprotein A1	Homo sapiens	82-88
19552907-7	2009	Incubation of macrophages (J774, THP-1 and MPM) with Fe/ascorbate ion, attenuated apoA-1 and HDL(3)-mediated cholesterol efflux whereas resveratrol (0-25microM) significantly redressed this attenuation in a dose-dependent manner (p&lt;0.001).	Iron	53-55	HDL3	Homo sapiens	93-98
26190951-0	2009	On the mechanism of iron sensing by IRP2: new players, new paradigms.	Iron	20-24	iron responsive element binding protein 2	Homo sapiens	36-40
19455640-5	2009	Oxidation of the His residue in PTH occurred when copper was used instead of iron.	Iron	77-81	parathyroid hormone	Homo sapiens	32-35
19776721-11	2009	Thus, matriptase-2 is critical for iron homeostasis and may have an important role in ESRD.	Iron	35-39	transmembrane serine protease 6	Homo sapiens	6-18
19753604-9	2009	It is concluded the presence of MRP in the diet negatively affects iron bioavailability.	Iron	67-71	ATP binding cassette subfamily C member 1	Homo sapiens	32-35
19946891-1	2009	Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free-heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron.	Iron	181-185	albumin	Homo sapiens	46-59
19946891-1	2009	Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free-heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron.	Iron	220-224	albumin	Homo sapiens	46-59
26190951-1	2009	Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization.	Iron	4-8	iron responsive element binding protein 2	Homo sapiens	39-43
26190951-1	2009	Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization.	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	39-43
26190951-2	2009	Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.	Iron	55-59	F-box and leucine rich repeat protein 5	Homo sapiens	114-119
19698763-4	2009	Inhibitors of heme oxygenases (HOs, which degrade heme to biliverdin, carbon monoxide, and iron) mimicked heme"s effects on PER2 rhythms.	Iron	91-95	period circadian clock 2	Mus musculus	124-128
19846308-1	2009	Iron-sulphur cluster deficiency myopathy is caused by a deep intronic mutation in ISCU resulting in inclusion of a cryptic exon in the mature mRNA.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	82-86
26190951-2	2009	Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	182-186
19838776-1	2009	Complexation of transferrin (Tf) and its receptor (TfR) is an essential event for iron uptake by the cell.	Iron	82-86	transferrin	Homo sapiens	16-27
19730160-8	2009	Compared with DF or DF + SS, we observed elevated plasma CRP levels and tubulointerstitial fibrosis in the IDA and IDA + Fe groups.	Iron	121-123	C-reactive protein	Rattus norvegicus	57-60
19838776-1	2009	Complexation of transferrin (Tf) and its receptor (TfR) is an essential event for iron uptake by the cell.	Iron	82-86	transferrin	Homo sapiens	29-31
20209848-7	2009	RESULTS: In iron-deficiency anemia, total iron-binding capacity of transferrin, soluble transferrin receptor and its index were enhanced, whereas serum iron, ferritinemia and transferrin saturation were low compared to controls.	Iron	12-16	transferrin	Homo sapiens	88-99
19782750-0	2009	Oxidation of elemental sulfur, tetrathionate and ferrous iron by the psychrotolerant Acidithiobacillus strain SS3.	Iron	49-61	SS3	Homo sapiens	110-113
19782750-2	2009	The purpose of this work was to characterize the oxidation of elemental sulfur (S(0)), tetrathionate (S4O6(2-)) and ferrous iron (Fe2+) by the psychrotolerant Acidithiobacillus strain SS3.	Iron	116-128	SS3	Homo sapiens	184-187
20209848-7	2009	RESULTS: In iron-deficiency anemia, total iron-binding capacity of transferrin, soluble transferrin receptor and its index were enhanced, whereas serum iron, ferritinemia and transferrin saturation were low compared to controls.	Iron	12-16	transferrin	Homo sapiens	67-78
20209848-7	2009	RESULTS: In iron-deficiency anemia, total iron-binding capacity of transferrin, soluble transferrin receptor and its index were enhanced, whereas serum iron, ferritinemia and transferrin saturation were low compared to controls.	Iron	12-16	transferrin	Homo sapiens	88-99
20209848-7	2009	RESULTS: In iron-deficiency anemia, total iron-binding capacity of transferrin, soluble transferrin receptor and its index were enhanced, whereas serum iron, ferritinemia and transferrin saturation were low compared to controls.	Iron	42-46	transferrin	Homo sapiens	67-78
19632191-0	2009	Fluorescence assay of non-transferrin-bound iron in thalassemic sera using bacterial siderophore.	Iron	44-48	transferrin	Homo sapiens	26-37
19716362-3	2009	The tumor suppressor p53 is induced upon iron depletion, and controls reactive oxygen species level.	Iron	41-45	tumor protein p53	Homo sapiens	21-24
19632191-1	2009	Transfusional iron overload associated with thalassemia leads to the appearance of non-transferrin-bound iron (NTBI) in blood that is toxic and causes morbidity and mortality via tissue damage.	Iron	14-18	transferrin	Homo sapiens	87-98
19632191-1	2009	Transfusional iron overload associated with thalassemia leads to the appearance of non-transferrin-bound iron (NTBI) in blood that is toxic and causes morbidity and mortality via tissue damage.	Iron	105-109	transferrin	Homo sapiens	87-98
19679144-12	2009	Zinc, nickel, vanadium, and iron increased hepatic MT-1 expression.	Iron	28-32	metallothionein 1	Rattus norvegicus	51-55
19775891-1	2009	Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.	Iron	147-151	egl-9 family hypoxia inducible factor 1	Homo sapiens	79-106
20449194-2	2009	[Fe(2)(HPO(4))(2)(C(2)O(4))(H(2)O)(2)] x 2 H(2)O, I, is a polymorph of a known phase and differs in the local arrangement of hydrophosphate, oxalate and coordinated water about iron, presenting a mer orientation of three coordinated phosphates, rather than fac as previously seen.	Iron	1-3	FA complementation group C	Homo sapiens	257-260
19775891-1	2009	Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.	Iron	147-151	egl-9 family hypoxia inducible factor 1	Homo sapiens	108-112
20396790-0	2009	Effect of iron ions on functional activity of thrombin.	Iron	10-14	coagulation factor II, thrombin	Homo sapiens	46-54
20396790-1	2009	The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma.	Iron	39-44	coagulation factor II, thrombin	Homo sapiens	16-24
20396790-1	2009	The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma.	Iron	39-44	coagulation factor II, thrombin	Homo sapiens	69-77
20396790-2	2009	The kinetic and concentration characteristics for recovery of thrombin activity by desferal were evaluated at various periods of thrombin incubation with iron ions.	Iron	154-158	coagulation factor II, thrombin	Homo sapiens	62-70
20396790-4	2009	Pretreatment of iron-containing incubation system with desferal was shown to decelerate the process of thrombin inactivation.	Iron	16-20	coagulation factor II, thrombin	Homo sapiens	103-111
20396790-6	2009	The effect of reversibility was shown to depend on the time of thrombin preincubation with iron.	Iron	91-95	coagulation factor II, thrombin	Homo sapiens	63-71
20396790-7	2009	Incomplete recovery of thrombin activity after increasing the time of incubation with iron (more than 30 min) was probably related to oxidative modification of thrombin.	Iron	86-90	coagulation factor II, thrombin	Homo sapiens	23-31
20396790-7	2009	Incomplete recovery of thrombin activity after increasing the time of incubation with iron (more than 30 min) was probably related to oxidative modification of thrombin.	Iron	86-90	coagulation factor II, thrombin	Homo sapiens	160-168
19766498-11	2009	Iron deposition may be attributed to the decrease in FP1 expression, and this inhibition of FP1 expression could be a major contributor to the formation of iron deposits in cerebral ischemia.	Iron	0-4	solute carrier family 40 member 1	Rattus norvegicus	53-56
19731237-2	2009	Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron.	Iron	194-198	catalase	Homo sapiens	153-156
19731237-12	2009	CONCLUSION: The combination of the GG-MPO genotype (leading to high MPO expression) and at least one Ala-SOD2 allele (associated with high liver iron score) markedly increased the risks of HCC occurrence and death in patients with alcoholic cirrhosis.	Iron	145-149	myeloperoxidase	Homo sapiens	38-41
19572995-0	2009	Non-transferrin-bound iron in haematological patients during chemotherapy and conditioning for autologous stem cell transplantation.	Iron	22-26	transferrin	Homo sapiens	4-15
19766498-11	2009	Iron deposition may be attributed to the decrease in FP1 expression, and this inhibition of FP1 expression could be a major contributor to the formation of iron deposits in cerebral ischemia.	Iron	156-160	solute carrier family 40 member 1	Rattus norvegicus	92-95
19693784-2	2009	The iron is delivered to actively dividing cells by receptor mediated endocytosis in which diferric TF preferentially binds to TF receptors (TFRs) on the cell surface and the entire complex is taken into an acidic endosome.	Iron	4-8	transferrin	Homo sapiens	100-102
19027283-7	2009	We therefore investigated the effects of hepcidin on the contents of Fpn1 and iron release in H9C2 cardiomyocyte cell line.	Iron	78-82	hepcidin antimicrobial peptide	Rattus norvegicus	41-49
19809161-0	2009	Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.	Iron	73-77	toll-like receptor 4	Mus musculus	24-28
19809161-8	2009	Our data suggest that low intracellular iron selectively impairs signaling via the TLR4/TRAM/TRIF pathway proximal to TRIF and results in reduced LPS-induced cytokine expression.	Iron	40-44	toll-like receptor 4	Mus musculus	83-87
19820698-3	2009	Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance.	Iron	73-77	transmembrane serine protease 6	Homo sapiens	26-33
19741202-1	2009	The extent to which the acute phase response (APR) influences iron status indicators in chronic infections is not well documented.	Iron	62-66	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	46-49
19997820-1	2009	BACKGROUND: Lactoferrin (Lf) is an 80-kDa basic glycoprotein, a member of the transferrin family of iron-binding proteins.	Iron	100-104	transferrin	Homo sapiens	78-89
19820699-0	2009	Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.	Iron	47-51	transmembrane serine protease 6	Homo sapiens	19-26
19820699-4	2009	These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.	Iron	68-72	transmembrane serine protease 6	Homo sapiens	46-53
19683594-7	2009	Spectral data indicate that both cytochrome c protein structure and a +3 heme iron oxidation state are required for the reaction mechanism to proceed optimally.	Iron	78-82	cytochrome c, somatic	Homo sapiens	33-45
18308429-8	2009	Exposure of RGC-5 cells to increased iron potentiated the neurotoxicity induced by paraquat, glutamate, and TNFalpha.	Iron	37-41	tumor necrosis factor	Mus musculus	108-116
19720833-1	2009	Fe(2+) is now shown to weaken binding between ferritin and mitochondrial aconitase messenger RNA noncoding regulatory structures ((iron-responsive element) (IRE)-RNAs) and the regulatory proteins (IRPs), which adds a direct role of iron to regulation that can complement the well known regulatory protein modification and degradative pathways related to iron-induced mRNA translation.	Iron	131-135	aconitase 2	Homo sapiens	59-82
19789237-8	2009	CONCLUSION: With a rat model similar to those already existing in the literature, skin changes were more marked in animals exposed to gadodiamide, Epo, and intravenous iron, as opposed to those animals exposed to gadodiamide alone; this experiment suggests that great caution may be warranted when prescribing gadolinium-based contrast agents to patients receiving Epo and intravenous iron.	Iron	168-172	erythropoietin	Homo sapiens	365-368
19720833-1	2009	Fe(2+) is now shown to weaken binding between ferritin and mitochondrial aconitase messenger RNA noncoding regulatory structures ((iron-responsive element) (IRE)-RNAs) and the regulatory proteins (IRPs), which adds a direct role of iron to regulation that can complement the well known regulatory protein modification and degradative pathways related to iron-induced mRNA translation.	Iron	232-236	aconitase 2	Homo sapiens	59-82
19720833-1	2009	Fe(2+) is now shown to weaken binding between ferritin and mitochondrial aconitase messenger RNA noncoding regulatory structures ((iron-responsive element) (IRE)-RNAs) and the regulatory proteins (IRPs), which adds a direct role of iron to regulation that can complement the well known regulatory protein modification and degradative pathways related to iron-induced mRNA translation.	Iron	232-236	aconitase 2	Homo sapiens	59-82
19762597-2	2009	However, the manner in which iron levels are sensed to affect IRP2 activity is poorly understood.	Iron	29-33	iron responsive element binding protein 2	Homo sapiens	62-66
19762596-2	2009	The degradation of iron regulatory protein 2 (IRP2) in iron-replete cells is a key event in this pathway, but the E3 ubiquitin ligase responsible for its proteolysis has remained elusive.	Iron	19-23	iron responsive element binding protein 2	Homo sapiens	46-50
19762597-4	2009	The stability of FBXL5 itself was regulated, accumulating under iron- and oxygen-replete conditions and degraded upon iron depletion.	Iron	64-68	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
19762596-3	2009	We found that a SKP1-CUL1-FBXL5 ubiquitin ligase protein complex associates with and promotes the iron-dependent ubiquitination and degradation of IRP2.	Iron	98-102	F-box and leucine rich repeat protein 5	Homo sapiens	26-31
19762596-3	2009	We found that a SKP1-CUL1-FBXL5 ubiquitin ligase protein complex associates with and promotes the iron-dependent ubiquitination and degradation of IRP2.	Iron	98-102	iron responsive element binding protein 2	Homo sapiens	147-151
19762597-4	2009	The stability of FBXL5 itself was regulated, accumulating under iron- and oxygen-replete conditions and degraded upon iron depletion.	Iron	118-122	F-box and leucine rich repeat protein 5	Homo sapiens	17-22
19762596-4	2009	The F-box substrate adaptor protein FBXL5 was degraded upon iron and oxygen depletion in a process that required an iron-binding hemerythrin-like domain in its N terminus.	Iron	60-64	F-box and leucine rich repeat protein 5	Homo sapiens	36-41
19762596-4	2009	The F-box substrate adaptor protein FBXL5 was degraded upon iron and oxygen depletion in a process that required an iron-binding hemerythrin-like domain in its N terminus.	Iron	116-120	F-box and leucine rich repeat protein 5	Homo sapiens	36-41
19762597-5	2009	FBXL5 contains an iron- and oxygen-binding hemerythrin domain that acted as a ligand-dependent regulatory switch mediating FBXL5"s differential stability.	Iron	18-22	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
19762596-5	2009	Thus, iron homeostasis is regulated by a proteolytic pathway that couples IRP2 degradation to intracellular iron levels through the stability and activity of FBXL5.	Iron	6-10	iron responsive element binding protein 2	Homo sapiens	74-78
19762596-5	2009	Thus, iron homeostasis is regulated by a proteolytic pathway that couples IRP2 degradation to intracellular iron levels through the stability and activity of FBXL5.	Iron	6-10	F-box and leucine rich repeat protein 5	Homo sapiens	158-163
19762597-5	2009	FBXL5 contains an iron- and oxygen-binding hemerythrin domain that acted as a ligand-dependent regulatory switch mediating FBXL5"s differential stability.	Iron	18-22	F-box and leucine rich repeat protein 5	Homo sapiens	123-128
19762596-5	2009	Thus, iron homeostasis is regulated by a proteolytic pathway that couples IRP2 degradation to intracellular iron levels through the stability and activity of FBXL5.	Iron	108-112	F-box and leucine rich repeat protein 5	Homo sapiens	158-163
19762597-6	2009	These observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis.	Iron	54-58	F-box and leucine rich repeat protein 5	Homo sapiens	75-80
19762597-1	2009	Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	214-218
19762597-1	2009	Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.	Iron	114-118	iron responsive element binding protein 2	Homo sapiens	214-218
19762597-1	2009	Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.	Iron	114-118	iron responsive element binding protein 2	Homo sapiens	214-218
19762597-6	2009	These observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis.	Iron	54-58	iron responsive element binding protein 2	Homo sapiens	101-105
19762597-6	2009	These observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis.	Iron	163-167	F-box and leucine rich repeat protein 5	Homo sapiens	75-80
19762597-6	2009	These observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis.	Iron	163-167	iron responsive element binding protein 2	Homo sapiens	101-105
19862332-4	2009	Increasing intracellular heme synthesis through the addition of aminolevulinic acid, protoporphyrin IX, or transferrin-bound iron increased the cytotoxicity of dihydroartemisinin, while decreasing heme synthesis through the addition of succinyl acetone decreased its cytotoxic activity.	Iron	125-129	transferrin	Homo sapiens	107-118
19785421-2	2009	By means of a simple and rapid experimental protocol (about 3 min/assay), the LOX/RNO reaction may simultaneously detect many antioxidant functions (scavenging of some physiological radical species, iron ion reducing and chelating activities, inhibition of the pro-oxidant apoenzyme), thus providing a comprehensive AA evaluation.	Iron	199-203	seed linoleate 9S-lipoxygenase-3	Glycine max	78-81
19646959-6	2009	Hypoxia (1% O(2)) and the iron chelator deferoxamine (DFX), a hypoxia mimetic, increased the levels of CXCR4 mRNA in A172 and T98G cells, and treatment with IFNgamma inhibited the expression of CXCR4 mRNA.	Iron	26-30	interferon gamma	Homo sapiens	157-165
19715344-9	2009	Overall, these results suggest that the ability of the Fra2-Grx3/4 complex to assemble a [2Fe-2S] cluster may act as a signal to control the iron regulon in response to cellular iron status in yeast.	Iron	141-145	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	60-66
19715344-9	2009	Overall, these results suggest that the ability of the Fra2-Grx3/4 complex to assemble a [2Fe-2S] cluster may act as a signal to control the iron regulon in response to cellular iron status in yeast.	Iron	178-182	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	60-66
20047224-7	2009	In comparison with control group, Hb and RET of the offspring whose mother feeded with low-level iron diet in pregnancy were significantly elevated after four and six weeks in intervention again.	Iron	97-101	ret proto-oncogene	Rattus norvegicus	41-44
19484405-3	2009	Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins.	Iron	5-9	transferrin	Homo sapiens	48-59
19505594-0	2009	Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron.	Iron	104-108	albumin	Homo sapiens	82-95
19505594-1	2009	Implications for non-transferrin-bound iron speciation.	Iron	39-43	transferrin	Homo sapiens	21-32
19505594-2	2009	Human serum albumin (HSA) is known as a low affinity iron binding protein and it has been proposed as a ligand for the non-transferrin-bound iron (NTBI) pool existing in the sera of iron-overload patients, but definitive evidence is still lacking.	Iron	53-57	albumin	Homo sapiens	6-19
19505594-2	2009	Human serum albumin (HSA) is known as a low affinity iron binding protein and it has been proposed as a ligand for the non-transferrin-bound iron (NTBI) pool existing in the sera of iron-overload patients, but definitive evidence is still lacking.	Iron	141-145	albumin	Homo sapiens	6-19
19505594-2	2009	Human serum albumin (HSA) is known as a low affinity iron binding protein and it has been proposed as a ligand for the non-transferrin-bound iron (NTBI) pool existing in the sera of iron-overload patients, but definitive evidence is still lacking.	Iron	141-145	transferrin	Homo sapiens	123-134
19505594-2	2009	Human serum albumin (HSA) is known as a low affinity iron binding protein and it has been proposed as a ligand for the non-transferrin-bound iron (NTBI) pool existing in the sera of iron-overload patients, but definitive evidence is still lacking.	Iron	141-145	albumin	Homo sapiens	6-19
19505594-2	2009	Human serum albumin (HSA) is known as a low affinity iron binding protein and it has been proposed as a ligand for the non-transferrin-bound iron (NTBI) pool existing in the sera of iron-overload patients, but definitive evidence is still lacking.	Iron	141-145	transferrin	Homo sapiens	123-134
19645734-6	2009	For example, plasminogen activator inhibitor 1 was shown to play a central role for steatosis, the anti-inflammatory adipokine, adiponectin profoundly regulates liver macrophage function and excessive hepatic deposition of iron is caused by chronic ethanol intoxication and increases the risk of hepatocellular carcinoma development.	Iron	223-227	adiponectin, C1Q and collagen domain containing	Homo sapiens	128-139
19484405-3	2009	Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins.	Iron	5-9	transferrin	Homo sapiens	88-99
19484405-4	2009	Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood.	Iron	22-26	transferrin	Homo sapiens	4-15
19861554-2	2009	Ferroportin (FPN) is the sole iron efflux transporter identified to date in animals, and there are two closely related orthologs in Arabidopsis thaliana, IRON REGULATED1 (IREG1/FPN1) and IREG2/FPN2.	Iron	154-158	iron regulated 1	Arabidopsis thaliana	171-176
19848169-2	2009	Here, we address the RAC system, containing a tunable amount of Fe as a primary electron donor coupled with Pd as an electrochemical catalyst to potentially respond to the characteristic of contaminated sites, effectively traps and treats various PCB congeners.	Iron	64-66	pyruvate carboxylase	Homo sapiens	247-250
19671018-7	2009	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells, which express CYP2E1 (E47 cells) but not control C34HepG2 cells, which do not express CYP2E1.	Iron	41-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	91-97
19720549-7	2009	Without Fe...S bond, the backbone and Calpha RMSD increased in holo cyt c"s perhaps resulting in enhanced peroxidase activity.	Iron	8-10	cytochrome c, somatic	Homo sapiens	68-73
20090884-2	2009	In the present study, we investigated the effect of cadmium on the expression of ferroportin 1 (FPN1), an important iron transporter protein that is involved in iron release from macrophages.	Iron	116-120	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	81-94
20090884-2	2009	In the present study, we investigated the effect of cadmium on the expression of ferroportin 1 (FPN1), an important iron transporter protein that is involved in iron release from macrophages.	Iron	116-120	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	96-100
19788558-5	2009	Here, we introduce the most important groups of human proteins, including haemoglobin, transferrin, lactoferrin and ferritin, which contain iron and that are potential iron sources for invading microorganisms.	Iron	140-144	transferrin	Homo sapiens	87-98
19788558-5	2009	Here, we introduce the most important groups of human proteins, including haemoglobin, transferrin, lactoferrin and ferritin, which contain iron and that are potential iron sources for invading microorganisms.	Iron	168-172	transferrin	Homo sapiens	87-98
19592582-0	2009	Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.	Iron	26-30	transmembrane serine protease 6	Homo sapiens	0-12
19592582-1	2009	Mutations leading to abrogation of matriptase-2 proteolytic activity in humans are associated with an iron-refractory iron deficiency anemia (IRIDA) due to elevated hepcidin levels.	Iron	102-106	transmembrane serine protease 6	Homo sapiens	35-47
19908442-3	2009	In this work, iron filled carbon nanotubes non-covalently functionalized by human serum albumin are studied as potential agents for hyperthermia.	Iron	14-18	albumin	Homo sapiens	82-95
19861554-2	2009	Ferroportin (FPN) is the sole iron efflux transporter identified to date in animals, and there are two closely related orthologs in Arabidopsis thaliana, IRON REGULATED1 (IREG1/FPN1) and IREG2/FPN2.	Iron	154-158	iron regulated 1	Arabidopsis thaliana	177-181
19608791-0	2009	Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3beta pathway in synaptic endings from adult and aged rats.	Iron	0-4	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
19608791-1	2009	In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and aged (28-month-old) rats.	Iron	169-173	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
19608791-1	2009	In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and aged (28-month-old) rats.	Iron	169-173	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
19608791-9	2009	We demonstrate here that synaptic endings from adult and aged animals subjected to iron-induced neurotoxicity show a differential profile in the activation of PI3K/Akt/GSK3beta.	Iron	83-87	AKT serine/threonine kinase 1	Rattus norvegicus	164-167
19805291-1	2009	Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts.	Iron	143-147	solute carrier family 25, member 37	Mus musculus	0-12
19524651-0	2009	Changes in serum hepcidin levels in acute iron intoxication in a rat model.	Iron	42-46	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
19524651-1	2009	Hepcidin is an important and recently discovered regulator of iron homeostasis.	Iron	62-66	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
19524651-4	2009	In the current study we aimed to investigate whether serum hepcidin levels are elevated in acute iron intoxication.	Iron	97-101	hepcidin antimicrobial peptide	Rattus norvegicus	59-67
19524651-8	2009	Serum hepcidin levels were significantly higher in the group treated with toxic doses of iron (p=0.005).	Iron	89-93	hepcidin antimicrobial peptide	Rattus norvegicus	6-14
19524651-10	2009	In acute iron intoxication serum hepcidin levels increase significantly and remain elevated for at least 6h.	Iron	9-13	hepcidin antimicrobial peptide	Rattus norvegicus	33-41
19524651-11	2009	We postulate that beyond the first hour after iron administration, serum hepcidin levels provide a better estimate of the amount of iron intake than do serum iron levels.	Iron	132-136	hepcidin antimicrobial peptide	Rattus norvegicus	73-81
19524651-11	2009	We postulate that beyond the first hour after iron administration, serum hepcidin levels provide a better estimate of the amount of iron intake than do serum iron levels.	Iron	132-136	hepcidin antimicrobial peptide	Rattus norvegicus	73-81
19560334-6	2009	The suppression of CH(4) production rates as well as total seasonal CH(4) flux could be due to the increased concentrations of active iron, free iron, manganese oxides, and sulfate in the amended soil, which acted as electron acceptors and controlled methanogens" activity by limiting substrates availability.	Iron	134-138	COP9 signalosome subunit 4	Drosophila melanogaster	19-24
19560334-6	2009	The suppression of CH(4) production rates as well as total seasonal CH(4) flux could be due to the increased concentrations of active iron, free iron, manganese oxides, and sulfate in the amended soil, which acted as electron acceptors and controlled methanogens" activity by limiting substrates availability.	Iron	134-138	COP9 signalosome subunit 4	Drosophila melanogaster	68-73
19560334-6	2009	The suppression of CH(4) production rates as well as total seasonal CH(4) flux could be due to the increased concentrations of active iron, free iron, manganese oxides, and sulfate in the amended soil, which acted as electron acceptors and controlled methanogens" activity by limiting substrates availability.	Iron	145-149	COP9 signalosome subunit 4	Drosophila melanogaster	19-24
19805291-1	2009	Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts.	Iron	143-147	solute carrier family 25, member 37	Mus musculus	14-19
19805291-1	2009	Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts.	Iron	143-147	solute carrier family 25, member 37	Mus musculus	21-29
19805291-1	2009	Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts.	Iron	201-205	solute carrier family 25, member 37	Mus musculus	0-12
19805291-1	2009	Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts.	Iron	201-205	solute carrier family 25, member 37	Mus musculus	14-19
19805291-1	2009	Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts.	Iron	201-205	solute carrier family 25, member 37	Mus musculus	21-29
19805291-2	2009	The biochemistry of Mfrn1-mediated iron transport into the mitochondria, however, is poorly understood.	Iron	35-39	solute carrier family 25, member 37	Mus musculus	20-25
19805291-3	2009	Here, we used the strategy of in vivo epitope-tagging affinity purification and mass spectrometry to investigate Mfrn1-mediated mitochondrial iron homeostasis.	Iron	142-146	solute carrier family 25, member 37	Mus musculus	113-118
19805291-7	2009	In undifferentiated MEL cells, cotransfected Abcb10 specifically interacts with Mfrn1 to enhance its protein stability and promote Mfrn1-dependent mitochondrial iron importation.	Iron	161-165	solute carrier family 25, member 37	Mus musculus	131-136
19805291-10	2009	These results suggest the tight regulation of mitochondrial iron acquisition and heme synthesis in erythroblasts is mediated by both transcriptional and posttranslational mechanisms, whereby the high level of Mfrn1 is stabilized by oligomeric protein complexes.	Iron	60-64	solute carrier family 25, member 37	Mus musculus	209-214
19591804-0	2009	The critical iron-oxygen intermediate in human aromatase.	Iron	13-17	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	47-56
19596281-3	2009	This regulatory mutation induces dynamic alterations in peripheral iron homeostasis such that newborn homozygous Pcm mice exhibit iron deficiency anemia with increased duodenal Fpn1 expression while adult homozygotes display decreased Fpn1 expression and anemia despite organismal iron overload.	Iron	67-71	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	113-116
19596281-3	2009	This regulatory mutation induces dynamic alterations in peripheral iron homeostasis such that newborn homozygous Pcm mice exhibit iron deficiency anemia with increased duodenal Fpn1 expression while adult homozygotes display decreased Fpn1 expression and anemia despite organismal iron overload.	Iron	130-134	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	113-116
19596281-4	2009	Herein we report the impact of the Pcm microdeletion on iron homeostasis in two compartments of the central nervous system: brain and retina.	Iron	56-60	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	35-38
19596281-5	2009	At birth, Pcm homozygotes show a marked decrease in brain iron content and reduced levels of Fpn1 expression.	Iron	58-62	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	10-13
19596281-6	2009	Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age.	Iron	153-157	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	169-172
19596281-8	2009	Strikingly, the adult Pcm brain is effectively protected from the peripheral iron overload and maintains normal iron content.	Iron	77-81	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	22-25
19596281-8	2009	Strikingly, the adult Pcm brain is effectively protected from the peripheral iron overload and maintains normal iron content.	Iron	112-116	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	22-25
19559788-2	2009	Nitrosative species were generated by 3-morpholinesydnonymine (SIN1) decomposition, using cyt c heme iron and/or molecular oxygen as electron acceptor.	Iron	101-105	MAPK associated protein 1	Homo sapiens	63-67
19685917-0	2009	Atypical effects of salts on the stability and iron release kinetics of human transferrin.	Iron	47-51	transferrin	Homo sapiens	78-89
19658411-4	2009	Here we show that the 221 cm(-1) mode of the photoproduct of iNOS(P420) does not exhibit any H(2)O-D(2)O solvent isotope shift such as that found in the iron-histidine stretching mode of myoglobin, indicating that the proximal ligand of iNOS(P420) is not a histidine.	Iron	153-157	nitric oxide synthase 2	Homo sapiens	61-65
19658411-4	2009	Here we show that the 221 cm(-1) mode of the photoproduct of iNOS(P420) does not exhibit any H(2)O-D(2)O solvent isotope shift such as that found in the iron-histidine stretching mode of myoglobin, indicating that the proximal ligand of iNOS(P420) is not a histidine.	Iron	153-157	nitric oxide synthase 2	Homo sapiens	61-70
19290777-0	2009	A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson"s disease.	Iron	16-20	glutaredoxin 2	Homo sapiens	86-100
19650117-11	2009	Iron-induced increase in oxidative stress was also associated with increased phosphorylation of ERK-, p38-, and JNK-mitogen-activated protein kinase (MAPK).	Iron	0-4	mitogen-activated protein kinase 14	Homo sapiens	102-105
19683100-0	2009	Hepcidin in acute iron toxicity.	Iron	18-22	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
19683100-1	2009	BACKGROUND: Hepcidin regulates extracellular iron concentration by inhibiting iron release from macrophages and preventing iron absorption in the intestine.	Iron	45-49	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
19683100-1	2009	BACKGROUND: Hepcidin regulates extracellular iron concentration by inhibiting iron release from macrophages and preventing iron absorption in the intestine.	Iron	78-82	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
19683100-1	2009	BACKGROUND: Hepcidin regulates extracellular iron concentration by inhibiting iron release from macrophages and preventing iron absorption in the intestine.	Iron	78-82	hepcidin antimicrobial peptide	Rattus norvegicus	12-20
19683100-8	2009	CONCLUSIONS: In acute iron intoxication, hepcidin expression in the liver significantly increased.	Iron	22-26	hepcidin antimicrobial peptide	Rattus norvegicus	41-49
19290777-0	2009	A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson"s disease.	Iron	146-150	glutaredoxin 2	Homo sapiens	86-100
19487139-2	2009	HFE binds to the transferrin receptor-1 (TfR1) in competition with iron-loaded transferrin (Fe-Tf).	Iron	67-71	transferrin	Homo sapiens	17-28
19596135-7	2009	It is suggested that an integrated Pd/Fe catalytic reduction-aerobic biodegradation process may be a feasible option for treating PCB-contaminated soil.	Iron	38-40	pyruvate carboxylase	Homo sapiens	130-133
19764221-1	2009	The objective of this study was to explore a bioremediation strategy based on injecting NO3- to support the anoxic oxidation of ferrous iron (Fe(II)) and arsenite (As(II)) in the subsurface as a means to immobilize As in the form of arsenate (As(V)) adsorbed onto biogenic ferric (Fe(III)) (hydr)oxides.	Iron	136-140	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
19482077-8	2009	Iron deposition detected in SOD1 KO mouse kidney is thought to be an inducer of GSTA4.	Iron	0-4	superoxide dismutase 1, soluble	Mus musculus	28-32
19581449-0	2009	KlAft, the Kluyveromyces lactis ortholog of Aft1 and Aft2, mediates activation of iron-responsive transcription through the PuCACCC Aft-type sequence.	Iron	82-86	Aft2p	Saccharomyces cerevisiae S288C	53-57
19501649-8	2009	Cellular ascorbate release is implicated in various homeostatic processes including ascorbate maintenance in blood and brain, and the uptake of non-transferrin-bound iron by cells.	Iron	166-170	transferrin	Homo sapiens	148-159
19664057-1	2009	Transferrin is the main iron transport protein found in the circulation, and the level of transferrin saturation in the blood is an important indicator of iron status.	Iron	24-28	transferrin	Homo sapiens	0-11
19664057-1	2009	Transferrin is the main iron transport protein found in the circulation, and the level of transferrin saturation in the blood is an important indicator of iron status.	Iron	24-28	transferrin	Homo sapiens	90-101
19664057-1	2009	Transferrin is the main iron transport protein found in the circulation, and the level of transferrin saturation in the blood is an important indicator of iron status.	Iron	155-159	transferrin	Homo sapiens	90-101
19664057-5	2009	First, an interaction between iron-free apo-transferrin and Gamide or Ggly was observed.	Iron	30-34	transferrin	Homo sapiens	44-55
19664057-9	2009	Third, monoferric transferrin mutants incapable of binding iron in either the N-terminal or C-terminal lobe still bound Ggly.	Iron	59-63	transferrin	Homo sapiens	18-29
19664057-10	2009	These findings are consistent with the hypothesis that gastrin peptides bind to nonligand residues within the open cleft in each lobe of transferrin and are involved in iron loading of transferrin in vivo.	Iron	169-173	transferrin	Homo sapiens	185-196
19604239-0	2009	Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia.	Iron	32-36	transferrin	Homo sapiens	14-25
19581449-5	2009	We identify an ortholog of AFT1/AFT2, designated KlAFT, whose deletion leads to the inability to grow under iron limitation.	Iron	108-112	Aft2p	Saccharomyces cerevisiae S288C	32-36
19581449-7	2009	However, homologs of Aft2-specific target genes encoding intracellular iron transporters are regulated neither by KlAft nor by iron.	Iron	71-75	Aft2p	Saccharomyces cerevisiae S288C	21-25
19699425-9	2009	Iron-transferrin saturation was 34.1% +/- 13.6%, and mean ferritin concentration was 53.6 +/- 33.2 ng/ml.	Iron	0-4	transferrin	Homo sapiens	5-16
19492434-4	2009	Mice lost their cellular iron stores indicating the requirement of ferritin H in iron deposition.	Iron	81-85	ferritin mitochondrial	Mus musculus	67-77
19342121-11	2009	Along with efficient ferric chelate reductase activity and root iron uptake activity, high expression levels of FRD3 genes are also proposed as a target for future iron efficiency breeding projects.	Iron	164-168	MATE efflux family protein	Arabidopsis thaliana	112-116
19492434-5	2009	Serum iron and transferrin saturation were slightly increased and correlated with a two-fold increased liver hepcidin 1 mRNA and a reduced duodenal DcytB mRNA level.	Iron	6-10	cytochrome b reductase 1	Mus musculus	148-153
19492434-7	2009	Mice fed on a high iron diet prior to ferritin H deletion suffered from severe liver damage.	Iron	19-23	ferritin mitochondrial	Mus musculus	38-48
19698085-3	2009	Each RGM also displays a discrete tissue-specific pattern of gene and protein expression, and each is proposed to have unique biological functions, ranging from axonal guidance during development (RGMa) to regulation of systemic iron metabolism (RGMc).	Iron	229-233	repulsive guidance molecule BMP co-receptor a	Homo sapiens	5-8
21305139-6	2009	We have therefore proposed that gastrins act as catalysts in the loading of transferrin with iron.	Iron	93-97	transferrin	Homo sapiens	76-87
19601561-1	2009	The interaction of cytochrome C and a number of its components such as the apo protein, heme and a coordinated iron with gold nanospheres, has been investigated.	Iron	111-115	cytochrome c, somatic	Homo sapiens	19-31
19721088-0	2009	Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control.	Iron	100-104	cytochrome c, somatic	Homo sapiens	0-12
19802746-0	2009	Maize ZmFDR3 localized in chloroplasts is involved in iron transport.	Iron	54-58	LOC541853	Zea mays	6-12
19802746-3	2009	Here, we describe the functional characterization of one of the genes identified in the screen, ZmFDR3 (Zea maize Fe-deficiency-related).	Iron	114-116	LOC541853	Zea mays	96-102
19802746-4	2009	Heterologous functional complementation assays using a yeast iron uptake mutant showed that ZmFDR3 functions in iron transport.	Iron	61-65	LOC541853	Zea mays	92-98
19802746-4	2009	Heterologous functional complementation assays using a yeast iron uptake mutant showed that ZmFDR3 functions in iron transport.	Iron	112-116	LOC541853	Zea mays	92-98
19802746-7	2009	Transgenic tobacco expressing a 35S-ZmFDR3 construct contains elevated iron content, displays well arranged thylakoid membranes and has photosynthetic indices that are higher than those of the wild type.	Iron	71-75	LOC541853	Zea mays	36-42
19802746-8	2009	Together, these results suggest that ZmFDR3 functions in chloroplast iron transport.	Iron	69-73	LOC541853	Zea mays	37-43
19698085-4	2009	All three RGM proteins appear capable of binding selected BMPs (bone morphogenetic proteins), and interactions with BMPs mediate at least some of the biological effects of RGMc on iron metabolism, but to date no role for BMPs has been defined in the actions of RGMa or RGMb.	Iron	180-184	repulsive guidance molecule BMP co-receptor a	Homo sapiens	10-13
19629033-6	2009	Thus, this ancient pathway has conserved and orchestrated mechanisms for trafficking, storing and reducing haem, which assure its use for cytochrome c synthesis even in limiting haem (iron) environments and reducing haem in oxidizing environments.	Iron	184-188	cytochrome c, somatic	Homo sapiens	138-150
19601593-11	2009	The binding of iron by Abeta modulates the redox potential to a level at which its redox cycling occurs.	Iron	15-19	amyloid beta precursor protein	Homo sapiens	23-28
19601593-15	2009	In addition, the strong binding affinity of Abeta toward Fe(III) and Fe(II) indicates Abeta could compete for iron against other iron-containing proteins.	Iron	110-114	amyloid beta precursor protein	Homo sapiens	44-49
19601593-15	2009	In addition, the strong binding affinity of Abeta toward Fe(III) and Fe(II) indicates Abeta could compete for iron against other iron-containing proteins.	Iron	110-114	amyloid beta precursor protein	Homo sapiens	86-91
19601593-15	2009	In addition, the strong binding affinity of Abeta toward Fe(III) and Fe(II) indicates Abeta could compete for iron against other iron-containing proteins.	Iron	129-133	amyloid beta precursor protein	Homo sapiens	44-49
19601593-15	2009	In addition, the strong binding affinity of Abeta toward Fe(III) and Fe(II) indicates Abeta could compete for iron against other iron-containing proteins.	Iron	129-133	amyloid beta precursor protein	Homo sapiens	86-91
19601593-16	2009	In particular, its strong affinity for Fe(II), which is 8 orders of magnitude stronger than that of transferrin, would greatly interfere with iron homeostasis.	Iron	142-146	transferrin	Homo sapiens	100-111
19601593-0	2009	Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer"s disease.	Iron	123-127	amyloid beta precursor protein	Homo sapiens	27-39
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	229-233
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	235-239
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	Mtm1p	Saccharomyces cerevisiae S288C	245-249
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	229-233
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	235-239
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	Mtm1p	Saccharomyces cerevisiae S288C	245-249
19561359-6	2009	Iron binds Sod2p in yeast mutants blocking late stages of iron-sulfur cluster biogenesis (grx5, ssq1, and atm1), but not in mutants defective in the upstream Isu proteins that serve as scaffolds for iron-sulfur biosynthesis.	Iron	0-4	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	90-94
19561359-6	2009	Iron binds Sod2p in yeast mutants blocking late stages of iron-sulfur cluster biogenesis (grx5, ssq1, and atm1), but not in mutants defective in the upstream Isu proteins that serve as scaffolds for iron-sulfur biosynthesis.	Iron	0-4	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	96-100
19454487-0	2009	Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.	Iron	34-38	LYR motif containing 4	Homo sapiens	6-11
19454487-0	2009	Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.	Iron	98-102	LYR motif containing 4	Homo sapiens	6-11
19454487-2	2009	Here, we have cloned and characterized human ISD11 and shown that human ISD11 forms a stable complex in vivo with the human cysteine desulfurase (ISCS), which generates the inorganic sulfur needed for Fe-S protein biogenesis.	Iron	201-205	LYR motif containing 4	Homo sapiens	45-50
19464362-9	2009	Chloride binding to the active site of MPO constrains ONOO(-) binding by filling the space directly above the heme moiety or by causing a protein conformational change that constricts the distal heme pocket, thus preventing ONOO(-) from binding to MPO heme iron.	Iron	257-261	myeloperoxidase	Homo sapiens	39-42
19454487-2	2009	Here, we have cloned and characterized human ISD11 and shown that human ISD11 forms a stable complex in vivo with the human cysteine desulfurase (ISCS), which generates the inorganic sulfur needed for Fe-S protein biogenesis.	Iron	201-205	LYR motif containing 4	Homo sapiens	72-77
19454487-5	2009	In addition, ISD11 suppression activated iron-responsive element-binding activity of iron regulatory protein 1, increased protein levels of iron regulatory protein 2, and resulted in abnormal punctate ferric iron accumulations in cells.	Iron	41-45	LYR motif containing 4	Homo sapiens	13-18
19454487-6	2009	These results indicate that ISD11 is important in the biogenesis of Fe-S clusters in mammalian cells, and its loss disrupts normal mitochondrial and cytosolic iron homeostasis.	Iron	68-72	LYR motif containing 4	Homo sapiens	28-33
19454487-6	2009	These results indicate that ISD11 is important in the biogenesis of Fe-S clusters in mammalian cells, and its loss disrupts normal mitochondrial and cytosolic iron homeostasis.	Iron	159-163	LYR motif containing 4	Homo sapiens	28-33
19574425-7	2009	These markers included high levels of scavenger receptors, CD163 and CD206, which are involved in both the scavenging of hemoglobin with iron transfer into macrophages and the silent clearance of inflammatory molecules.	Iron	137-141	CD163 antigen	Mus musculus	59-64
19491103-2	2009	Analysis of highly conserved components of the yeast ISC assembly machinery shows that the iron-chaperone, Yfh1, and the sulfur-donor complex, Nfs1-Isd11, directly bind to each other.	Iron	91-95	LYR motif containing 4	Homo sapiens	148-153
19491103-5	2009	Binding of Yfh1 to Nfs1-Isd11 or Isu1 requires oligomerization of Yfh1 and can occur in an iron-independent manner.	Iron	91-95	LYR motif containing 4	Homo sapiens	24-29
19527900-3	2009	RESULTS: Iron-supplement users (n = 212/1000) showed significantly higher values of prepregnancy body mass index (BMI), actual BMI, waist circumference, blood pressure, fasting glucose, Homeostasis-Model-Assessment-Insulin-Resistance, and lower high-density lipoprotein-cholesterol than nonusers.	Iron	9-13	insulin	Homo sapiens	215-222
19572596-0	2009	A novel iron-catalyzed decarboxylative Csp3-Csp2 coupling of proline derivatives and naphthol.	Iron	8-12	regulator of calcineurin 2	Homo sapiens	44-48
19308466-0	2009	Iron-sulfur cluster biosynthesis: characterization of IscU-IscS complex formation and a structural model for sulfide delivery to the [2Fe-2S] assembly site.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	54-58
19187935-3	2009	Under flow, iron loading to endothelial cells promoted an increased number of tumor necrosis factor-alpha-mediated firm arrest of human monocytes.	Iron	12-16	tumor necrosis factor	Homo sapiens	78-105
19567699-0	2009	Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy.	Iron	50-54	iron-sulfur cluster assembly enzyme	Homo sapiens	33-37
19567699-4	2009	The clinical, histochemical and biochemical phenotype is very homogenous and the patients are homozygous for a deep intronic IVS5 + 382G>C splicing affecting mutation in ISCU, which encodes the differently spliced cytosolic and mitochondrial iron-sulphur cluster assembly protein IscU.	Iron	242-246	iron-sulfur cluster assembly enzyme	Homo sapiens	170-174
19567699-4	2009	The clinical, histochemical and biochemical phenotype is very homogenous and the patients are homozygous for a deep intronic IVS5 + 382G>C splicing affecting mutation in ISCU, which encodes the differently spliced cytosolic and mitochondrial iron-sulphur cluster assembly protein IscU.	Iron	242-246	iron-sulfur cluster assembly enzyme	Homo sapiens	280-284
19567699-5	2009	Iron-sulphur cluster containing proteins are essential for iron homeostasis and respiratory chain function, with IscU being among the most conserved proteins in evolution.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	113-117
19567699-5	2009	Iron-sulphur cluster containing proteins are essential for iron homeostasis and respiratory chain function, with IscU being among the most conserved proteins in evolution.	Iron	59-63	iron-sulfur cluster assembly enzyme	Homo sapiens	113-117
19656490-4	2009	We identified SLC25A39, SLC22A4, and TMEM14C, which are putative mitochondrial transporters, as well as C1orf69 and ISCA1, which are iron-sulfur cluster proteins.	Iron	133-137	IBA57 homolog, iron-sulfur cluster assembly	Mus musculus	104-111
19351705-2	2009	In previous studies, we have identified FOX1 and ATX1 FEREs (Fe deficiency-responsive elements) as important regulation components of iron response in this organism.	Iron	134-138	RNA binding fox-1 homolog 1	Homo sapiens	40-44
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Iron	92-96	apolipoprotein E	Mus musculus	233-237
19621374-4	2009	Fe(III) induces the release of the Ga ions due to the higher affinity constant and also prevents the Ga(III) species from accessing the iron-binding pockets of Tf.	Iron	136-140	transferrin	Homo sapiens	160-162
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Iron	92-96	apolipoprotein E	Mus musculus	239-251
19117049-2	2009	Slow and prolonged transdermal delivery of iron would also avoid potential oversaturation of transferrin and overcome accumulation of free iron in the systemic circulation.	Iron	43-47	transferrin	Rattus norvegicus	93-104
19138881-2	2009	BACKGROUND: Low iron stores have been found to be a risk factor for RLS with serum ferritin levels less than 45-50 ng/mL associated with increased severity of RLS.	Iron	16-20	RLS1	Homo sapiens	68-71
19765379-0	2009	[BMP6: a key player in iron metabolism].	Iron	23-27	bone morphogenetic protein 6	Homo sapiens	1-5
19695063-10	2009	The concentrations of both non-transferrin-bound iron and ferritin were significantly higher in dialysis patients.	Iron	49-53	transferrin	Homo sapiens	31-42
19577786-0	2009	Preparation and evaluation of iron-chitosan composites for removal of As(III) and As(V) from arsenic contaminated real life groundwater.	Iron	30-34	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-87
19453295-1	2009	Mrs3p and Mrs4p (Mrs3/4p) are yeast mitochondrial iron carrier proteins that play important roles in ISC (iron-sulphur cluster) and haem biosynthesis.	Iron	50-54	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-5
19185424-0	2009	Sorption behavior of Pb(II) and Cd(II) on iron ore slime and characterization of metal ion loaded sorbent.	Iron	42-46	submaxillary gland androgen regulated protein 3B	Homo sapiens	21-27
19185424-1	2009	The present investigation evaluates the sorption effectiveness of Pb(II) and Cd(II) ions on iron ore slime (IOS) obtained from Jindal Steel Ltd., Vijayanagaram, India.	Iron	92-96	submaxillary gland androgen regulated protein 3B	Homo sapiens	66-72
19485411-2	2009	The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain.	Iron	362-364	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-161
19485411-2	2009	The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain.	Iron	362-364	acetylcholinesterase (Cartwright blood group)	Homo sapiens	163-167
19485411-2	2009	The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain.	Iron	362-364	amyloid beta precursor protein	Homo sapiens	220-245
19453295-1	2009	Mrs3p and Mrs4p (Mrs3/4p) are yeast mitochondrial iron carrier proteins that play important roles in ISC (iron-sulphur cluster) and haem biosynthesis.	Iron	50-54	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-4
19453295-1	2009	Mrs3p and Mrs4p (Mrs3/4p) are yeast mitochondrial iron carrier proteins that play important roles in ISC (iron-sulphur cluster) and haem biosynthesis.	Iron	106-110	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-5
19453295-1	2009	Mrs3p and Mrs4p (Mrs3/4p) are yeast mitochondrial iron carrier proteins that play important roles in ISC (iron-sulphur cluster) and haem biosynthesis.	Iron	106-110	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-4
19453295-2	2009	At low iron conditions, mitochondrial and cytoplasmic ISC protein maturation is correlated with MRS3/4 expression.	Iron	7-11	Fe(2+) transporter	Saccharomyces cerevisiae S288C	96-100
19588382-15	2009	Two studies used supplemental iron in the RT plus EPO group and not in the RT alone group.	Iron	30-34	erythropoietin	Homo sapiens	50-53
19492851-0	2009	Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB.	Iron	30-34	iron-sulfur cluster assembly enzyme	Homo sapiens	76-80
19492851-1	2009	IscU is a scaffold protein that functions in iron-sulfur cluster assembly and transfer.	Iron	45-49	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
19498004-1	2009	Heme oxygenase-1 (HO-1) catalyzes the conversion of heme into carbon monoxide (CO), iron, and biliverdin.	Iron	84-88	heme oxygenase 1	Mus musculus	0-16
19166904-0	2009	Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.	Iron	76-80	amyloid beta precursor protein	Homo sapiens	0-25
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	62-66	melanotransferrin	Mus musculus	0-17
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	62-66	melanotransferrin	Mus musculus	19-22
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	68-70	melanotransferrin	Mus musculus	0-17
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	68-70	melanotransferrin	Mus musculus	19-22
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	96-98	melanotransferrin	Mus musculus	0-17
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	96-98	melanotransferrin	Mus musculus	19-22
19245822-2	2009	MTf has been implicated in diverse processes, e.g., iron metabolism, plasminogen activation, eosinophil differentiation and cancer cell migration, proliferation and tumourigenesis.	Iron	52-56	melanotransferrin	Mus musculus	0-3
19245822-7	2009	Richardson, Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo, Blood 107 (2006) 2599-2601).	Iron	41-45	melanotransferrin	Mus musculus	20-37
19175946-12	2009	It may be possible to develop algorithms, based on the markers of the APR and Fe status, to assess the Fe status among the patients with tuberculosis or other infections eliciting an APR.	Iron	78-80	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	183-186
19175946-12	2009	It may be possible to develop algorithms, based on the markers of the APR and Fe status, to assess the Fe status among the patients with tuberculosis or other infections eliciting an APR.	Iron	103-105	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	70-73
19175946-12	2009	It may be possible to develop algorithms, based on the markers of the APR and Fe status, to assess the Fe status among the patients with tuberculosis or other infections eliciting an APR.	Iron	103-105	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	183-186
18501198-4	2009	Several epidemiological studies have reported a positive association between high body iron stores, as measured by circulating ferritin level, and the risk of type 2 diabetes and of other insulin resistant states such as the metabolic syndrome, gestational diabetes and polycystic ovarian syndrome.	Iron	87-91	insulin	Homo sapiens	188-195
18501198-7	2009	Further, several clinical trials have suggested that phlebotomy induced reduction in body iron levels may improve insulin sensitivity in humans.	Iron	90-94	insulin	Homo sapiens	114-121
18619522-6	2009	In rats, infusion of angiotensin II increases ferritin levels and arterial thickness which are reversed by treatment with the iron chelator deferoxamine.	Iron	126-130	angiotensinogen	Rattus norvegicus	21-35
18619522-7	2009	In humans, a polymorphism for haptoglobin associated with increased cardiovascular disease is also characterized by increased lesional iron.	Iron	135-139	haptoglobin	Homo sapiens	30-41
18992790-3	2009	Chronic transfusion results in accumulation of excess iron that surpasses the binding capacity of the major iron transport protein, transferrin.	Iron	108-112	transferrin	Homo sapiens	132-143
18992790-4	2009	The resulting non-transferrin bound iron (NTBI) can catalyze the production of highly reactive oxygen species (ROS) leading to significant and wide spread injury to the liver, heart, and endocrine organs as well as increases in infection.	Iron	36-40	transferrin	Homo sapiens	18-29
19328214-1	2009	We previously showed that, in the rat hepatoma cell line HTC, TNF brings about a non-caspase-dependent, apoptosis-like process requiring NADPH oxidase activity, an iron-mediated pro-oxidant status, and a functional acidic vacuolar compartment.	Iron	164-168	tumor necrosis factor	Rattus norvegicus	62-65
19498004-1	2009	Heme oxygenase-1 (HO-1) catalyzes the conversion of heme into carbon monoxide (CO), iron, and biliverdin.	Iron	84-88	heme oxygenase 1	Mus musculus	18-22
20298397-1	2009	INTRODUCTION: The influence of the degree of immunoglobulin E (IgE) sensitisation on the fraction of expired nitric oxide (FE(NO)) in asthma patients being treated with inhaled corticosteroids (ICS) is not well known.	Iron	123-126	immunoglobulin heavy constant epsilon	Homo sapiens	45-61
19594550-10	2009	Serum LDH, ALT and AST activity, as well as MDA content, GRP78 expression and caspase 12 activity in the heart and liver, were upregulated in chronically iron-loaded rats.	Iron	154-158	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	19-22
19594550-12	2009	Serum LDH, ALT and AST activity, MDA content in the heart and liver and levels of ER stress markers were all increased in acute iron-loaded rats.	Iron	128-132	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	19-22
20298397-1	2009	INTRODUCTION: The influence of the degree of immunoglobulin E (IgE) sensitisation on the fraction of expired nitric oxide (FE(NO)) in asthma patients being treated with inhaled corticosteroids (ICS) is not well known.	Iron	123-126	immunoglobulin heavy constant epsilon	Homo sapiens	63-66
19673278-6	2009	Our results illustrate that As reduction is favorable over a wide-range of field conditions, and Fe reduction is differentially favorable depending on the buildup of metabolites (mainly Fe2+) and the Fe (hydr)oxide being reduced; reduction of As(V) is thermodynamically favorable under most environmental conditions and almost always more favorable than goethite and hematite reduction.	Iron	97-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	243-248
19444865-2	2009	Hyperferritinemia, which suggests that iron overload plays a decisive role in the pathophysiology of insulin resistance and hyperglycemia, is a common finding in both disorders.	Iron	39-43	insulin	Homo sapiens	101-108
19444865-5	2009	Iron overload will enhance intrahepatic oxidative stress that promotes hepatic fibrosis, interfere with insulin signalling at various levels and may hamper hepatic insulin extraction.	Iron	0-4	insulin	Homo sapiens	104-111
19444865-7	2009	Furthermore, iron depletion by phlebotomy removes liver iron content and reduces serum glucose and insulin resistance in NAFLD patients.	Iron	13-17	insulin	Homo sapiens	99-106
19444865-9	2009	Concerning chronic HCV infection, it has been classically assumed that iron overload contributes to insulin resistance associated with virus infection.	Iron	71-75	insulin	Homo sapiens	100-107
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19404207-11	2009	TNF-alpha produced by activated lymphocytes inhibited iron export from CaCo2 cells.	Iron	54-58	tumor necrosis factor	Homo sapiens	0-9
19798981-3	2009	In the present paper, the direct interaction between heme-iron of myoglobin and additional metal ions [Cu (II), Zn (II) and Co( II)] was studied by UV-Vis spectra.	Iron	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-131
21637505-1	2009	Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation.	Iron	63-67	haptoglobin	Homo sapiens	0-11
21637505-1	2009	Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation.	Iron	171-175	haptoglobin	Homo sapiens	0-11
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19798993-1	2009	In the present work, the iron oxyhydroxides were prepared by hydrolysis and neutralization of ferric ion from FeCl3, Fe(NO3)3 and Fe2 (SO4)3 salts, under the conditions of various pH values and aging for about 6 days at 60 degrees C. These iron minerals were identified and characterized using X-ray diffraction (XRD), infrared spectroscopy (IR) and scanning electron microscopy (SEM).	Iron	25-29	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
19264680-0	2009	Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin.	Iron	35-39	erythropoietin	Homo sapiens	103-117
19495930-8	2009	All patients responded to intravenous iron therapy (transferrin saturation values of the patients were &gt;50%).	Iron	38-42	transferrin	Homo sapiens	52-63
23105843-3	2009	A significant increase in plasma iron binding capacity points to beneficial effect of copper bhasm on liver as transferrin is synthesized in liver.	Iron	33-37	transferrin	Homo sapiens	111-122
19558223-7	2009	Finally, the release of a proinflammatory cytokine (i.e. IL-8) by the exposed cells similarly increased with cell iron concentration.	Iron	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
19285877-2	2009	The results indicate that in the 2.5-6.2 pH range Fe(III) interacts with As(V) leading to the sorption of As(V) on Fe(III) precipitates or Fe-As coprecipitates.	Iron	50-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	73-78
19285877-2	2009	The results indicate that in the 2.5-6.2 pH range Fe(III) interacts with As(V) leading to the sorption of As(V) on Fe(III) precipitates or Fe-As coprecipitates.	Iron	50-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	106-111
19380872-0	2009	Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood.	Iron	25-29	alpha-2-macroglobulin	Mus musculus	67-88
19415898-1	2009	During the operation of cytochrome bc(1), a key enzyme of biological energy conversion, the iron-sulfur head domain of one of the subunits of the catalytic core undergoes a large-scale movement from the catalytic quinone oxidation Q(o) site to cytochrome c(1).	Iron	92-96	cytochrome c, somatic	Homo sapiens	244-256
19549340-9	2009	MPO positive cells were more frequent in occlusive than non-occlusive thrombi adjacent to ruptures (p = .006) and were more numerous in diabetics compared to non-diabetics (p = .002) CONCLUSION: Unstable fibrous caps are more likely to contain MPO-positive cells, neutrophils, and iron-containing macrophages than fibrous caps of stable fibroatheromas.	Iron	281-285	myeloperoxidase	Homo sapiens	0-3
19498125-3	2009	iron formulations on serum ferritin concentration (SFC) and transferrin saturation (TSAT) are compared in adult hemodialysis patients with anemia receiving erythropoiesis-stimulating agents (ESAs).	Iron	0-4	transferrin	Homo sapiens	60-71
19380872-10	2009	The demonstration that alpha2-M is the hepcidin transporter could lead to better understanding of hepcidin physiology, methods for its sensitive measurement and the development of novel drugs for the treatment of iron-related diseases.	Iron	213-217	alpha-2-macroglobulin	Mus musculus	23-31
19517015-10	2009	Similarly, THP-1 cells achieved approximately 10 pg-iron/cell at 48 h when labeled with 100 microg/ml of Fe and 3 microg/ml of Pro.	Iron	52-56	GLI family zinc finger 2	Homo sapiens	11-16
19478456-1	2009	Grx5 from the yeast Saccharomyces cerevisiae is a monothiol glutaredoxin that is involved in iron-sulfur cluster biogenesis.	Iron	93-97	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	0-4
19462090-1	2009	His mediates iron delivery to the [2Fe-2S] assembly site of ISU/IscU scaffold proteins, but is not required for the binding of iron or cluster.	Iron	13-17	iron-sulfur cluster assembly enzyme	Homo sapiens	64-68
19386738-4	2009	Body iron was determined from hemoglobin, serum ferritin, and transferrin receptor.	Iron	5-9	transferrin	Homo sapiens	62-73
19384939-9	2009	Subsequent quantitative PCR experiments validated 12 candidate genes; with GSTM1, eIF5a, SULF2, NTS, and HO-1 being particularly good prospects as genes that might affect the degree of iron accumulation.	Iron	185-189	glutathione S-transferase mu 1	Homo sapiens	75-80
19717155-0	2009	WITHDRAWN: The Haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque.	Iron	101-105	haptoglobin	Homo sapiens	15-26
19307463-7	2009	On the other hand, expression of hepcidin, TfR2, ferroportin 1 and DMT1 were significantly up-regulated in iron-loaded non-cirrhotic non-tumorous liver tissues as compared with normal liver controls.	Iron	107-111	charged multivesicular body protein 2B	Homo sapiens	67-71
19344417-0	2009	Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection.	Iron	73-77	interleukin 6	Homo sapiens	37-50
19344417-7	2009	We concluded that even mild increases in serum hepcidin and IL-6 concentrations result in a disturbed host iron homeostasis.	Iron	107-111	interleukin 6	Homo sapiens	60-64
18506200-1	2009	OBJECTIVES: The acute phase response (APR) influences indicators of iron status.	Iron	68-72	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	38-41
18506200-4	2009	We examined whether the APR (measured by AGP) influences the expected relationships between iron status indicators in an HIV-infected population.	Iron	92-96	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	24-27
18506200-10	2009	CONCLUSIONS: AGP captured the influence of the APR on iron indicators and their relationships with each other.	Iron	54-58	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	47-50
18506200-15	2009	We support the WHO/CDC recommendation that AGP is a useful indicator to assess the influence of the APR on iron status indicators.	Iron	107-111	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	100-103
19377077-0	2009	Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.	Iron	51-55	transmembrane serine protease 6	Homo sapiens	0-12
19377077-0	2009	Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.	Iron	51-55	transmembrane serine protease 6	Homo sapiens	14-21
19377077-3	2009	The type-two transmembrane serine protease (TTSP), matriptase-2 (also known as TMPRSS6), is attracting significant amounts of interest due to its recently described role in iron homeostasis.	Iron	173-177	transmembrane serine protease 6	Homo sapiens	51-63
19377077-3	2009	The type-two transmembrane serine protease (TTSP), matriptase-2 (also known as TMPRSS6), is attracting significant amounts of interest due to its recently described role in iron homeostasis.	Iron	173-177	transmembrane serine protease 6	Homo sapiens	79-86
19377077-8	2009	In this review, after overviewing the membrane anchored serine proteases, in particular the TTSP family, we summarize the identification and characterization of matriptase-2 and describe its functional relevance in iron metabolism.	Iron	215-219	transmembrane serine protease 6	Homo sapiens	161-173
19449457-4	2009	We found that key regulators of iron homeostasis, hepcidin and IL-6, were increased in gangliosidoses mice.	Iron	32-36	interleukin 6	Mus musculus	63-67
19290554-2	2009	Iron release from human serum transferrin (hTF) has been studied extensively; however, the molecular details of the mechanism(s) remain incomplete.	Iron	0-4	transferrin	Homo sapiens	30-41
19398238-5	2009	There was an inverse correlation between intestinal iron absorption and plasma hepcidin (r = -0.61, p &lt; 0.001), HOMA (r = -0.35, p = 0.01) and C reactive protein (r = -0.52, p &lt; 0.001).	Iron	52-56	C-reactive protein	Homo sapiens	146-164
19250966-0	2009	A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson"s disease.	Iron	48-52	transferrin	Homo sapiens	8-19
19493198-2	2009	In Pseudomonas aeruginosa, an important human opportunistic pathogen, the tol-oprL genes are organized uniquely in three operons, orf1-tolQRA, tolB and oprL-orf2, and are regulated by iron availability.	Iron	184-188	ORF1	Homo sapiens	130-134
19493198-7	2009	Our results revealed two distinct promoters at the upstream region of tolQRA; the one located in front of orf1 was constitutive whereas the other within the orf1 coding region was iron regulated.	Iron	180-184	ORF1	Homo sapiens	157-161
19951529-10	2009	CONCLUSIONS: CDA-I is a rare congenital anemia characterized by ineffective erythropoiesis, jaundice, hepatosplenomegaly and iron overload, and may be misdiagnosed.	Iron	125-129	codanin 1	Homo sapiens	13-18
18805635-1	2009	Advanced Fenton process (AFP) using zero valent metallic iron (ZVMI) is studied as a potential technique to degrade the azo dye in the aqueous medium.	Iron	57-61	alpha fetoprotein	Homo sapiens	25-28
19366254-1	2009	Local protein backbone dynamics of the camphor hydroxylase cytochrome P450(cam) (CYP101) depend upon the oxidation and ligation state of the heme iron.	Iron	146-150	calmodulin 3	Homo sapiens	59-79
19339248-6	2009	In contrast, the placement of the SCN(-) ion in the structure of myeloperoxidase (MPO) occurs with an opposite orientation, in which the nitrogen atom is closer to the heme iron than the sulfur atom.	Iron	173-177	myeloperoxidase	Homo sapiens	65-80
19339248-6	2009	In contrast, the placement of the SCN(-) ion in the structure of myeloperoxidase (MPO) occurs with an opposite orientation, in which the nitrogen atom is closer to the heme iron than the sulfur atom.	Iron	173-177	myeloperoxidase	Homo sapiens	82-85
19296829-4	2009	In the present study, we have characterized the molecular pathways of iron turnover in the liver of Sod1-deficient mice.	Iron	70-74	superoxide dismutase 1, soluble	Mus musculus	100-104
19320465-2	2009	Excessive Cu and Fe ions binding to Abeta were suggested to have a deleterious effect on promoting both the aggregation of Abeta and the generation of reactive oxygen species (ROS).	Iron	17-19	amyloid beta precursor protein	Homo sapiens	36-41
19320465-2	2009	Excessive Cu and Fe ions binding to Abeta were suggested to have a deleterious effect on promoting both the aggregation of Abeta and the generation of reactive oxygen species (ROS).	Iron	17-19	amyloid beta precursor protein	Homo sapiens	123-128
19296829-7	2009	These results suggest that concerted changes in the hepatic expression of iron- and haem-related genes in response to haemolytic anaemia in Sod1-/- mice act to reduce toxic iron accumulation in the liver and respond to the needs of erythropoiesis.	Iron	74-78	superoxide dismutase 1, soluble	Mus musculus	140-144
19296829-7	2009	These results suggest that concerted changes in the hepatic expression of iron- and haem-related genes in response to haemolytic anaemia in Sod1-/- mice act to reduce toxic iron accumulation in the liver and respond to the needs of erythropoiesis.	Iron	173-177	superoxide dismutase 1, soluble	Mus musculus	140-144
21825468-0	2009	In situ x-ray reflectivity and grazing incidence x-ray diffraction study of L 1(0) ordering in (57)Fe/Pt multilayers.	Iron	99-101	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	76-82
19324057-0	2009	Existence of a noncanonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry.	Iron	37-41	transferrin	Homo sapiens	48-59
19324057-3	2009	In this work, hydrogen/deuterium exchange was used in combination with mass spectrometry to map solvent-accessible surfaces of the iron-bound and iron-free forms of the N-terminal lobe of human serum Tf at both neutral and endosomal pH levels.	Iron	131-135	transferrin	Homo sapiens	200-202
19324057-3	2009	In this work, hydrogen/deuterium exchange was used in combination with mass spectrometry to map solvent-accessible surfaces of the iron-bound and iron-free forms of the N-terminal lobe of human serum Tf at both neutral and endosomal pH levels.	Iron	146-150	transferrin	Homo sapiens	200-202
21825468-1	2009	In situ high temperature x-ray reflectivity and grazing incidence x-ray diffraction measurements in the energy dispersive mode are used to study the ordered face-centered tetragonal (fct) L 1(0) phase formation in [Fe(19 A)/Pt(25 A)]( x 10) multilayers prepared by ion beam sputtering.	Iron	215-217	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	188-194
19221770-2	2009	Accumulation of amyloid-beta peptide (Abeta) in cultured brain vascular smooth muscle cells that overexpress human amyloid-beta precursor protein (APP) Swedish, is strongly enhanced by exposure to iron ions.	Iron	197-201	amyloid beta precursor protein	Homo sapiens	115-145
20641561-0	2004	(124)I-Serum albumin-manganese-magnetism-engineered iron oxide nanoparticles The superparamagnetic iron oxide (SPIO) structure is composed of ferric iron (Fe(3+)) and ferrous iron (Fe(2+)).	Iron	167-179	albumin	Homo sapiens	7-20
19387319-13	2009	I-PTH contributes to excessive FE P partially on po day 1 but not thereafter.	Iron	31-33	parathyroid hormone	Homo sapiens	2-5
19357218-8	2009	C-reactive protein was elevated in 28.8 +/- 3.1% of females with ID by the ferritin model but not by the body iron model and in 0% of persons with ID by the body iron model but not by the ferritin model.	Iron	110-114	C-reactive protein	Homo sapiens	0-18
19357218-8	2009	C-reactive protein was elevated in 28.8 +/- 3.1% of females with ID by the ferritin model but not by the body iron model and in 0% of persons with ID by the body iron model but not by the ferritin model.	Iron	162-166	C-reactive protein	Homo sapiens	0-18
19444013-3	2009	The characteristic biochemical abnormalities are elevated serum transferrin-iron saturation and serum ferritin.	Iron	76-80	transferrin	Homo sapiens	64-75
19442627-6	2009	Grx5 deficiency results in impaired biogenesis of Fe-S cluster in yeast.	Iron	50-54	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	0-4
19442627-8	2009	Since reduced formation of Fe-S cluster would lead to increased level of free iron, a competitive inhibitor of manganese superoxide dismutase (MnSOD), we measured MnSOD activity in Grx5 deficient osteoblasts and found MnSOD activity was significantly reduced.	Iron	27-31	superoxide dismutase 2, mitochondrial	Mus musculus	111-141
19442627-8	2009	Since reduced formation of Fe-S cluster would lead to increased level of free iron, a competitive inhibitor of manganese superoxide dismutase (MnSOD), we measured MnSOD activity in Grx5 deficient osteoblasts and found MnSOD activity was significantly reduced.	Iron	27-31	superoxide dismutase 2, mitochondrial	Mus musculus	143-148
19442627-8	2009	Since reduced formation of Fe-S cluster would lead to increased level of free iron, a competitive inhibitor of manganese superoxide dismutase (MnSOD), we measured MnSOD activity in Grx5 deficient osteoblasts and found MnSOD activity was significantly reduced.	Iron	27-31	superoxide dismutase 2, mitochondrial	Mus musculus	163-168
19442627-8	2009	Since reduced formation of Fe-S cluster would lead to increased level of free iron, a competitive inhibitor of manganese superoxide dismutase (MnSOD), we measured MnSOD activity in Grx5 deficient osteoblasts and found MnSOD activity was significantly reduced.	Iron	27-31	superoxide dismutase 2, mitochondrial	Mus musculus	163-168
19442627-8	2009	Since reduced formation of Fe-S cluster would lead to increased level of free iron, a competitive inhibitor of manganese superoxide dismutase (MnSOD), we measured MnSOD activity in Grx5 deficient osteoblasts and found MnSOD activity was significantly reduced.	Iron	78-82	superoxide dismutase 2, mitochondrial	Mus musculus	111-141
19442627-8	2009	Since reduced formation of Fe-S cluster would lead to increased level of free iron, a competitive inhibitor of manganese superoxide dismutase (MnSOD), we measured MnSOD activity in Grx5 deficient osteoblasts and found MnSOD activity was significantly reduced.	Iron	78-82	superoxide dismutase 2, mitochondrial	Mus musculus	143-148
19442627-12	2009	Our findings are consistent with the hypothesis that Grx5 is an important determinant of osteoblast apoptosis and acts via a molecular pathway that involves regulation of ROS production, cardiolipin oxidation, caspase activity, Fe-S cluster formation, and MnSOD activity.	Iron	228-232	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	53-57
19366358-2	2009	We proposed that intracellular application of the parent, iron-free tetraaza[14]annulene ligand, TAA-1, as precursor would allow antioxidative defense along two lines, i.e. by chelation of potentially toxic cellular iron ions and, subsequently, by catalase-mimic activity.	Iron	58-62	catalase	Rattus norvegicus	248-256
19270112-9	2009	GO term analysis identified biological processes significantly affected by Cdc53p depletion, including amino acid starvation response, with 14 genes being targets of the transcriptional regulator Gcn4p, and reductive iron transport.	Iron	217-221	cullin CDC53	Saccharomyces cerevisiae S288C	75-81
19144479-2	2009	This study was conducted to explore the relationship between serum transferrin saturation (as iron is a potential carcinogen) and presence of colon adenomas.	Iron	94-98	transferrin	Homo sapiens	67-78
19285482-0	2009	The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane.	Iron	61-65	Fe(2+) transporter	Saccharomyces cerevisiae S288C	41-46
19285482-2	2009	A vertebrate Mrs3/4 homologue named mitoferrin was shown to be essential for erythroid iron utilization and proposed to function as an essential mitochondrial iron importer.	Iron	87-91	Fe(2+) transporter	Saccharomyces cerevisiae S288C	13-17
19285482-2	2009	A vertebrate Mrs3/4 homologue named mitoferrin was shown to be essential for erythroid iron utilization and proposed to function as an essential mitochondrial iron importer.	Iron	159-163	Fe(2+) transporter	Saccharomyces cerevisiae S288C	13-17
19285482-3	2009	Indirect reporter assays in isolated yeast mitochondria indicated that the Mrs3/4 proteins are involved in mitochondrial Fe(2+) utilization or transport under iron-limiting conditions.	Iron	159-163	Fe(2+) transporter	Saccharomyces cerevisiae S288C	75-79
19285482-4	2009	To have a more direct test for Mrs3/4p mediated iron uptake into mitochondria we studied iron (II) transport across yeast inner mitochondrial membrane vesicles (SMPs) using the iron-sensitive fluorophore PhenGreen SK (PGSK).	Iron	48-52	Fe(2+) transporter	Saccharomyces cerevisiae S288C	31-35
19298223-0	2009	The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.	Iron	9-13	mechanistic target of rapamycin kinase	Homo sapiens	67-71
19366358-6	2009	By comparison with authentic TAA-1/Fe, an intracellular formation of 2.0 +/- 0.3 microm of the active catalase mimic in native hepatocytes exposed to TAA-1 and of 6.5 +/- 1.0 microm in hepatocytes exposed to both TAA-1 and iron ions was estimated.	Iron	223-227	catalase	Rattus norvegicus	102-110
19366358-7	2009	The intracellular formation of the active catalase mimic thus renders TAA-1 an attractive compound for protection against iron- and/or hydrogen peroxide-dependent cell injuries.	Iron	122-126	catalase	Rattus norvegicus	42-50
19228823-9	2009	In multi-variable linear regression analysis, fetuin A was independently associated with TG level and total iron binding capacity after adjustments for age, hemoglobin, albumin, calcium, body mass index, and hs-CRP.	Iron	108-112	alpha 2-HS glycoprotein	Homo sapiens	46-54
19554531-0	2009	[C-reactive protein in the assessment of iron status in patients on hemodialysis].	Iron	41-45	C-reactive protein	Homo sapiens	1-19
19554531-1	2009	Iron availability is a prerequisite for an efficient hematopoietic response to erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	79-93
19554531-7	2009	On the other hand, measurement of CRP, which is both sensitive and easily measurable with automated techniques, might possibly be used as a surrogate measure of iron status in hemodialysis patients.	Iron	161-165	C-reactive protein	Homo sapiens	34-37
19386032-0	2009	Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2.	Iron	35-39	transmembrane serine protease 6	Homo sapiens	71-83
19232737-12	2009	We excluded the possibility that the increased Cp or Tf could provide the required substrate to stimulate Fe efflux, and instead demonstrate that Cu can substitute for Fe in the iron regulatory protein - iron responsive element regulation mechanism.	Iron	106-108	transferrin	Homo sapiens	53-55
19264360-2	2009	In this paper, a BSA (bovine serum albumin)-lecithin liposome system was used to study the nature of different forms of iron, including methemoglobin, hemin and ferric citrate, in catalyzing H(2)O(2)-nitrite system to oxidize protein and lipid as well as nitrate protein.	Iron	120-124	albumin	Homo sapiens	29-42
19384570-2	2009	In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway.	Iron	30-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-68
19384570-2	2009	In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway.	Iron	30-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
19386032-5	2009	As a novel suppressor of hepcidin expression, matriptase-2 emerges as a possible candidate for therapeutic interventions aimed at treating disorders of iron metabolism.	Iron	152-156	transmembrane serine protease 6	Homo sapiens	46-58
19321187-2	2009	Cr(VI) and As(V) were observed to be subject to different impacts induced by co-existing As(V) or Cr(VI), humic acid and bicarbonate, originating from their distinct removal mechanisms by Fe(0).	Iron	188-190	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	11-16
19252923-0	2009	Arabidopsis IRT2 cooperates with the high-affinity iron uptake system to maintain iron homeostasis in root epidermal cells.	Iron	51-55	iron regulated transporter 2	Arabidopsis thaliana	12-16
19252923-0	2009	Arabidopsis IRT2 cooperates with the high-affinity iron uptake system to maintain iron homeostasis in root epidermal cells.	Iron	82-86	iron regulated transporter 2	Arabidopsis thaliana	12-16
19252923-3	2009	Arabidopsis IRT2 gene, whose expression is induced in root epidermis upon iron deprivation, was shown to encode a functional iron/zinc transporter in yeast, and proposed to function in iron acquisition from the soil.	Iron	74-78	iron regulated transporter 2	Arabidopsis thaliana	12-16
19252923-3	2009	Arabidopsis IRT2 gene, whose expression is induced in root epidermis upon iron deprivation, was shown to encode a functional iron/zinc transporter in yeast, and proposed to function in iron acquisition from the soil.	Iron	125-129	iron regulated transporter 2	Arabidopsis thaliana	12-16
19252923-6	2009	However, IRT2 appears strictly co-regulated with FRO2 and IRT1, supporting the view that IRT2 is an integral component of the root response to iron deficiency in root epidermal cells.	Iron	143-147	iron regulated transporter 2	Arabidopsis thaliana	9-13
19252923-6	2009	However, IRT2 appears strictly co-regulated with FRO2 and IRT1, supporting the view that IRT2 is an integral component of the root response to iron deficiency in root epidermal cells.	Iron	143-147	iron regulated transporter 2	Arabidopsis thaliana	89-93
19252923-7	2009	We propose a model where IRT2 likely prevents toxicity from IRT1-dependent iron fluxes in epidermal cells, through compartmentalization.	Iron	75-79	iron regulated transporter 2	Arabidopsis thaliana	25-29
19321187-1	2009	The interactions of co-present Cr(VI) and As(V), and the influences of humic acid and bicarbonate in the process of Cr(VI) and As(V) removal by Fe(0) were investigated in a batch setting using simulated groundwater with 5 mM NaCl, 1 mM Na(2)SO(4), and 0.8 mM CaCl(2) as background electrolytes at an initial pH value of 7.	Iron	144-146	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	127-132
19321187-2	2009	Cr(VI) and As(V) were observed to be subject to different impacts induced by co-existing As(V) or Cr(VI), humic acid and bicarbonate, originating from their distinct removal mechanisms by Fe(0).	Iron	188-190	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	89-94
19321187-3	2009	Cr(VI) removal is a reduction-dominated process, whereas As(V) removal principally involves adsorption onto iron corrosion products.	Iron	108-112	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	57-62
19321187-8	2009	In the presence of bicarbonate, both Cr(VI) and As(V) removal was increased and the inhibitory effect of Cr(VI) on As(V) removal was suppressed, resulting from the buffering effects and the promoted iron corrosion induced by bicarbonate, and the formation of CaCO(3) in solution, which enhanced As(V) adsorption.	Iron	199-203	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-120
19321187-8	2009	In the presence of bicarbonate, both Cr(VI) and As(V) removal was increased and the inhibitory effect of Cr(VI) on As(V) removal was suppressed, resulting from the buffering effects and the promoted iron corrosion induced by bicarbonate, and the formation of CaCO(3) in solution, which enhanced As(V) adsorption.	Iron	199-203	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-120
19352532-2	2009	Dysfunctional interactions of metal ions, especially those of Cu, Zn, and Fe, with the amyloid-beta (Abeta) peptide are hypothesised to play an important role in the aetiology of AD, and disruption of these aberrant metal-peptide interactions via chelation therapy holds considerable promise as a therapeutic strategy.	Iron	74-76	amyloid beta precursor protein	Homo sapiens	87-99
19352532-2	2009	Dysfunctional interactions of metal ions, especially those of Cu, Zn, and Fe, with the amyloid-beta (Abeta) peptide are hypothesised to play an important role in the aetiology of AD, and disruption of these aberrant metal-peptide interactions via chelation therapy holds considerable promise as a therapeutic strategy.	Iron	74-76	amyloid beta precursor protein	Homo sapiens	101-106
19352532-3	2009	Tetrahydrosalens such as (2)(1-5) have a significant affinity for metal ions, and thus should be able to compete with the Abeta peptide for Cu, Zn, and Fe in the brain.	Iron	152-154	amyloid beta precursor protein	Homo sapiens	122-127
19258014-1	2009	Transferrin (Tf) is an iron carrier protein that consists of two lobes, the N- and C-lobes, which can each bind a Fe(3+) ion.	Iron	23-27	transferrin	Homo sapiens	0-11
19383473-3	2009	At pH 7, bicarbonate was found to be the most effective for both manganese and iron binding, with dissociation constants around 1 muM in three of the mutants.	Iron	79-83	latexin	Homo sapiens	130-133
19258014-1	2009	Transferrin (Tf) is an iron carrier protein that consists of two lobes, the N- and C-lobes, which can each bind a Fe(3+) ion.	Iron	114-116	transferrin	Homo sapiens	0-11
19361235-2	2009	[FeCp*(2)][TCNE] is the first organic-based ferromagnetic material to be synthesized and is known to have two structural phase transitions at 249 and 282 K. The low-temperature phase, which exhibits spontaneous ferromagnetic order below 4.8 K, was determined at 12 K. At that temperature, it has monoclinic space group P2(1)/c [a = 9.6637(4) A, b = 14.1217(5) A, c = 18.6256(7) A, beta = 113.231(2) degrees, Z = 4] and consists of parallel chains of alternating [Fe(C(5)Me(5))(2)](*+) and [TCNE](*-) ions, with an intrachain Fe...Fe distance of 10.45 A.	Iron	1-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	319-326
19296689-4	2009	The 11 mutants of human cyt c expressed in the course of this research have been characterized by UV-vis spectroscopy, circular dichroism, and NMR spectroscopy to verify overall structure integrity as well as axial coordination of the heme iron.	Iron	240-244	cytochrome c, somatic	Homo sapiens	24-29
19204324-6	2009	These effects are mediated through down-regulation of phosphorylation of Stat3 triggered by LPS and of Smad1/5/8 induced by iron.	Iron	124-128	signal transducer and activator of transcription 3	Homo sapiens	73-78
19367733-6	2009	Antioxidant enzymes, including ascorbate peroxidase and peroxiredoxin Q, were only detected in the Fe-deficient samples.	Iron	99-101	Thioredoxin superfamily protein	Arabidopsis thaliana	56-71
19204324-8	2009	Our findings also suggest that erythropoietic drive can inhibit both inflammatory and iron-sensing pathways, at least in part, via the suppression of STAT3 and SMAD4 signaling in vivo.	Iron	86-90	signal transducer and activator of transcription 3	Homo sapiens	150-155
19321419-10	2009	Our observations suggest that mutations in Nramp1 could result in a novel form of human hereditary iron overload.	Iron	99-103	solute carrier family 11 member 1	Homo sapiens	43-49
19281164-1	2009	The nonheme iron enzyme phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase catalyze the hydroxylation of their aromatic amino acid substrates using a tetrahydropterin as the source of electrons.	Iron	12-16	tyrosine hydroxylase	Homo sapiens	51-71
19281173-0	2009	Inequivalent contribution of the five tryptophan residues in the C-lobe of human serum transferrin to the fluorescence increase when iron is released.	Iron	133-137	transferrin	Homo sapiens	87-98
19281173-1	2009	Human serum transferrin (hTF), with two Fe3+ binding lobes, transports iron into cells.	Iron	71-75	transferrin	Homo sapiens	12-23
19210523-0	2009	Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection.	Iron	92-96	B cell leukemia/lymphoma 2	Mus musculus	27-32
19176888-11	2009	Further analysis indicated that iron levels in the fetal, and not maternal, liver regulate the expression of liver transferrin receptor and hepcidin expression in the mother.	Iron	32-36	hepcidin antimicrobial peptide	Rattus norvegicus	140-148
19292870-12	2009	In addition, the lack of cleavage protection in patients with alpha-1 antitrypsin deficiency may be the reason for the disturbance in their iron homeostasis.	Iron	140-144	serpin family A member 1	Homo sapiens	62-81
19156547-2	2009	Because iron incorporated into cells by the transferrin receptor is essential for cell/nuclear function, we determined whether fetal oocyte expression of transferrin receptor and the nuclear protein Ki67 were developmentally regulated by estrogen and associated with DNA integrity/fragmentation.	Iron	8-12	serotransferrin	Papio anubis	44-55
18951995-7	2009	Scavenging hydrogen peroxide or iron only reversed the late phase of resveratrol-induced NHE-1 promoter repression.	Iron	32-36	solute carrier family 9 member A1	Homo sapiens	89-94
19409188-1	2009	Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family that is expressed and secreted by glandular cells and found in the secondary granules of neutrophils from which it is released in infected tissues and blood during the inflammatory process.	Iron	23-27	transferrin	Homo sapiens	56-67
19338078-0	2009	BMP6 orchestrates iron metabolism.	Iron	18-22	bone morphogenetic protein 6	Homo sapiens	0-4
19223469-7	2009	These studies provide insight into the structural basis for IRP2-RNA interactions and reveal an iron-independent mechanism for regulating iron homeostasis through the redox regulation of IRP2 cysteines.	Iron	96-100	iron responsive element binding protein 2	Homo sapiens	187-191
19223469-1	2009	Iron regulatory protein 2 (IRP2) is an RNA-binding protein that regulates the posttranscriptional expression of proteins required for iron homeostasis such as ferritin and transferrin receptor 1.	Iron	134-138	iron responsive element binding protein 2	Homo sapiens	0-25
19223469-1	2009	Iron regulatory protein 2 (IRP2) is an RNA-binding protein that regulates the posttranscriptional expression of proteins required for iron homeostasis such as ferritin and transferrin receptor 1.	Iron	134-138	iron responsive element binding protein 2	Homo sapiens	27-31
19223469-2	2009	IRP2 RNA-binding activity is primarily regulated by iron-mediated proteasomal degradation, but studies have suggested that IRP2 RNA binding is also regulated by thiol oxidation.	Iron	52-56	iron responsive element binding protein 2	Homo sapiens	0-4
19121106-6	2009	The susceptibility of the double nramp3 nramp4 mutant is associated with the reduced accumulation of reactive oxygen species and ferritin (AtFER1), an iron storage protein known to participate in A. thaliana defense.	Iron	151-155	ferretin 1	Arabidopsis thaliana	139-145
19042175-8	2009	These results could be partly explained by iron deficiency: 46% of patients had a serum ferritin between 200 and 500 microg/l and about one third of patients had a transferrin-iron saturation percentage greater or equal to 30% at baseline and at the end of the study.	Iron	43-47	transferrin	Homo sapiens	164-175
19217259-9	2009	CONCLUSION: These results suggest that vitamin A maintains iron homeostasis by the modulation of liver hepcidin expression.	Iron	59-63	hepcidin antimicrobial peptide	Rattus norvegicus	103-111
18336871-6	2009	Interleukin-6 appears to be the central mediator of anemia of chronic disease in a range of inflammatory diseases, including end-stage renal disease and rheumatoid arthritis, through increased generation of hepcidin and the resultant alterations in iron metabolism.	Iron	249-253	interleukin 6	Homo sapiens	0-13
19228837-2	2009	Transferrin (Tf) is the main protein regulating Fe homeostasis, whereas Ceruplasmin (CP) is a circulating ferroxidase enzyme able to oxidize ferrous ions to less toxic ferric forms.	Iron	48-50	transferrin	Homo sapiens	0-11
19129187-5	2009	Sequence analysis suggests that a related iron staple nuclease domain is present in the eukaryotic DNA replication/repair factor Dna2, where it is also associated with a DNA helicase motor.	Iron	42-46	DNA replication helicase/nuclease 2	Homo sapiens	129-133
19162396-1	2009	A series of Fe(54+/-1)Pt(46+/-1) thin films have been sputter-deposited and annealed at various times and temperatures to facilitate the A1 to L1(0) polymorphic phase transformation.	Iron	12-14	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	143-148
19275250-0	2009	Unusual electronic features and reactivity of the dipyridylazaallyl ligand: characterizations of (smif)2M [M = Fe, Co, Co+, Ni; smif = {(2-py)CH}2N] and [(TMS)2NFe]2(smif)2.	Iron	111-113	decapping mRNA 1A	Homo sapiens	98-102
19348738-1	2009	We and others have previously reported that lactotransferrin (LF), acting both as an iron-binding protein and inflammatory modulator, is greatly up-regulated in the brain of patients with Alzheimer"s disease (AD).	Iron	85-89	lactotransferrin	Homo sapiens	44-60
19348738-1	2009	We and others have previously reported that lactotransferrin (LF), acting both as an iron-binding protein and inflammatory modulator, is greatly up-regulated in the brain of patients with Alzheimer"s disease (AD).	Iron	85-89	lactotransferrin	Homo sapiens	62-64
19263519-5	2009	Consistent with this, the induction of cellular HIF-1alpha protein by manganese (II) was abolished by pretreatment with iron.	Iron	120-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
18621480-1	2009	Reductive dechlorination of carbon tetrachloride (CT) and 1,1,1-trichloroethane (1,1,1-TCA) by FeS with transition metals (Cu(II), Co(II), and Ni(II)) and hydrosulfide was characterized in this study.	Iron	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18621480-5	2009	The rate constants with 10mM Co(II) and Ni(II) were 0.06 and 0.11h(-1), approximately 1.3 and 3.0 times greater than those by FeS alone.	Iron	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19136608-5	2009	The iron-deficient diet initially induced severe anemia, which resulted in LV hypertrophy and dilation with preserved systolic function associated with increased serum erythropoietin (Epo) concentration.	Iron	4-8	erythropoietin	Homo sapiens	168-182
19233068-2	2009	Exploring the provenance of erythropoietin resistance may be facilitated by the consideration of the pathogenetic triad of iron-restricted erythropoiesis, inflammation, and bone marrow suppression.	Iron	123-127	erythropoietin	Homo sapiens	28-42
19233068-3	2009	Challenging to diagnose because of difficulty in interpreting tests of iron deficiency, iron-restricted erythropoiesis should be considered in patients who require high doses of erythropoietin, have low transferrin saturation (eg, &lt;20%-25%), and do not have very high ferritin (eg, &lt;1,200 ng/mL); a therapeutic trial of intravenous iron may be worthwhile.	Iron	88-92	erythropoietin	Homo sapiens	178-192
19233068-3	2009	Challenging to diagnose because of difficulty in interpreting tests of iron deficiency, iron-restricted erythropoiesis should be considered in patients who require high doses of erythropoietin, have low transferrin saturation (eg, &lt;20%-25%), and do not have very high ferritin (eg, &lt;1,200 ng/mL); a therapeutic trial of intravenous iron may be worthwhile.	Iron	88-92	transferrin	Homo sapiens	203-214
19233068-7	2009	In summary, improving the outcomes of erythropoietin-resistant patients will require complete patient assessment that goes beyond considerations of iron and erythropoietin dose alone.	Iron	148-152	erythropoietin	Homo sapiens	38-52
19233073-4	2009	Traditional iron markers such as serum ferritin and transferrin saturation ratio (TSAT) (ie, serum iron divided by total iron-binding capacity [TIBC]), may be confounded by non-iron-related conditions.	Iron	12-16	transferrin	Homo sapiens	52-63
19136608-5	2009	The iron-deficient diet initially induced severe anemia, which resulted in LV hypertrophy and dilation with preserved systolic function associated with increased serum erythropoietin (Epo) concentration.	Iron	4-8	erythropoietin	Homo sapiens	184-187
19103311-1	2009	Human serum transferrin (hTF) is a bilobal glycoprotein that transports iron to cells.	Iron	72-76	transferrin	Homo sapiens	12-23
19254567-5	2009	We report two hepatic cell lines, WIF-B cells and HepG2 cells transfected with HFE, where hepcidin expression responded to iron-loaded transferrin.	Iron	123-127	transferrin	Homo sapiens	135-146
19103311-0	2009	Incorporation of 5-hydroxytryptophan into transferrin and its receptor allows assignment of the pH induced changes in intrinsic fluorescence when iron is released.	Iron	146-150	transferrin	Homo sapiens	42-53
18983994-2	2009	It has been shown that phosphatidic acid (PA) and phosphatidylhydroxyacetone (PHA) were formed in the system under conditions where hydrogen peroxide favours a release of heme iron from cyt c.	Iron	176-180	cytochrome c, somatic	Homo sapiens	186-191
18800231-7	2009	The most predictive model of EPO response for the pediatric cohort had, as the major variables, urea clearance x dialysis duration/total body water (Kt/V), urea reduction ratio (URR), intact parathyroid hormone (iPTH), blood loss, normalized protein catabolic rates (nPCR) and indices of malnutrition and inflammation, whereas adults had iron and folate deficiencies as the dominant variables.	Iron	338-342	erythropoietin	Homo sapiens	29-32
19261002-4	2009	Though genetic factors, insulin resistance, dysregulation of iron-regulatory molecules, erythrophagocytosis by Kupffer cells may be responsible for hepatic iron accumulation in NASH, exact mechanisms involved in iron overload remain to be clarified.	Iron	156-160	insulin	Homo sapiens	24-31
19261002-5	2009	Iron reduction therapy such as phlebotomy or dietary iron restriction may be promising in patients with NASH/NAFLD to reduce insulin resistance as well as serum transaminase activities.	Iron	0-4	insulin	Homo sapiens	125-132
19261002-5	2009	Iron reduction therapy such as phlebotomy or dietary iron restriction may be promising in patients with NASH/NAFLD to reduce insulin resistance as well as serum transaminase activities.	Iron	53-57	insulin	Homo sapiens	125-132
18410348-0	2009	Intravenous iron attenuates postvaccination anti-HBsAg titres after quadruple hepatitis B vaccination in dialysis patients with erythropoietin therapy.	Iron	12-16	erythropoietin	Homo sapiens	128-142
18997094-0	2009	Alteration in iron metabolism during retinal degeneration in rd10 mouse.	Iron	14-18	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	61-65
18997094-9	2009	Three-week-old rd10 mice also had a 1.4-fold increase in total retinal iron level (P = 0.05).	Iron	71-75	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	15-19
19116239-8	2009	In the latter subjects, the change in serum prohepcidin after iron depletion was associated with the change in both fasting glucose transferrin (r = 0.58; P = 0.02) and saturation (r = 0.68; P = 0.005).	Iron	62-66	transferrin	Homo sapiens	132-143
19116239-9	2009	The changes in insulin sensitivity were associated with those of liver iron content (r = -0.64; P = 0.007) and with those of serum prohepcidin (r = -0.50; P = 0.04) (cohort 3).	Iron	71-75	insulin	Homo sapiens	15-22
18787531-0	2009	Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling.	Iron	0-4	interferon gamma	Homo sapiens	44-52
18787531-2	2009	We have previously shown the treatment of cells with chelators which preferentially bind iron inhibits IFNgamma-mediated induction of IFN regulatory factor 1 in endothelial cells.	Iron	89-93	interferon gamma	Homo sapiens	103-111
19252502-7	2009	TfR1-mediated iron uptake promoted osteoclast differentiation and bone-resorbing activity, associated with the induction of mitochondrial respiration, production of reactive oxygen species and accelerated Ppargc1b transcription.	Iron	14-18	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	205-213
19283067-9	2009	These results suggest that sequestration of iron in PrP(Sc)-ferritin complexes induces a state of iron bio-insufficiency in prion disease-affected brains, resulting in increased uptake and a state of iron dyshomeostasis.	Iron	44-48	prion protein	Homo sapiens	52-55
19283067-9	2009	These results suggest that sequestration of iron in PrP(Sc)-ferritin complexes induces a state of iron bio-insufficiency in prion disease-affected brains, resulting in increased uptake and a state of iron dyshomeostasis.	Iron	98-102	prion protein	Homo sapiens	52-55
18800231-10	2009	In summary EPO resistance in the pediatric dialysis cohort was predicted by nutritional deficits, inflammation, poor dialysis, and hyperparathyroidism, while iron and folate deficits were the major determinants in adults.	Iron	158-162	erythropoietin	Homo sapiens	11-14
19245700-0	2009	The importance of iron in long-term survival of maintenance hemodialysis patients treated with epoetin-alfa and intravenous iron: analysis of 9.5 years of prospectively collected data.	Iron	18-22	erythropoietin	Homo sapiens	95-102
19282658-3	2009	HO-1 degrades heme into carbon monoxide (CO), biliverdin, and iron.	Iron	62-66	heme oxygenase 1	Mus musculus	0-4
19567093-16	2009	Infusing intravenous iron sucrose 200 mg every two weeks can maintain the serum iron parameters and hemoglobin level in maintenance peritoneal dialysis patients and n permits reduction of the required dose of EPO.	Iron	21-25	erythropoietin	Homo sapiens	209-212
19232720-0	2009	WITHDRAWN: The effect of dihydroartemisinin on TfR and VEGF expression in iron overload human myeloid leukemia K562 cells.	Iron	74-78	vascular endothelial growth factor A	Homo sapiens	55-59
19173569-0	2009	Vibrational dynamics of iron in cytochrome C.	Iron	24-28	cytochrome c, somatic	Homo sapiens	32-44
19173569-1	2009	Nuclear resonance vibrational spectroscopy (NRVS) and Raman spectroscopy on (54)Fe- and (57)Fe-enriched cytochrome c (cyt c) identify multiple bands involving vibrations of the heme Fe.	Iron	92-94	cytochrome c, somatic	Homo sapiens	104-116
19173569-1	2009	Nuclear resonance vibrational spectroscopy (NRVS) and Raman spectroscopy on (54)Fe- and (57)Fe-enriched cytochrome c (cyt c) identify multiple bands involving vibrations of the heme Fe.	Iron	92-94	cytochrome c, somatic	Homo sapiens	118-123
19173569-4	2009	The stiffness of the low-spin Fe environment in both oxidation states of cyt c significantly exceeds that for the high-spin Fe in deoxymyoglobin, where the 200-300 cm(-1) frequency range dominates the VDOS.	Iron	30-32	cytochrome c, somatic	Homo sapiens	73-78
19173569-6	2009	The longer Fe-S(Met80) in oxidized cyt c with respect to reduced cyt c leads to a decrease in the stiffness of the iron environment upon oxidation.	Iron	11-15	cytochrome c, somatic	Homo sapiens	35-40
19173569-6	2009	The longer Fe-S(Met80) in oxidized cyt c with respect to reduced cyt c leads to a decrease in the stiffness of the iron environment upon oxidation.	Iron	11-15	cytochrome c, somatic	Homo sapiens	65-70
19173569-6	2009	The longer Fe-S(Met80) in oxidized cyt c with respect to reduced cyt c leads to a decrease in the stiffness of the iron environment upon oxidation.	Iron	115-119	cytochrome c, somatic	Homo sapiens	35-40
19173569-6	2009	The longer Fe-S(Met80) in oxidized cyt c with respect to reduced cyt c leads to a decrease in the stiffness of the iron environment upon oxidation.	Iron	115-119	cytochrome c, somatic	Homo sapiens	65-70
19173569-8	2009	We consider the possibility that the 372 cm(-1) band in reduced cyt c involves the Fe-S(Met80) bond.	Iron	83-87	cytochrome c, somatic	Homo sapiens	64-69
19196960-1	2009	Native cytochrome c (cyt c) has a compact tertiary structure with a hexacoordinated heme iron and functions in electron transport in mitochondria and apoptosis in the cytoplasm.	Iron	89-93	cytochrome c, somatic	Homo sapiens	7-19
19196960-1	2009	Native cytochrome c (cyt c) has a compact tertiary structure with a hexacoordinated heme iron and functions in electron transport in mitochondria and apoptosis in the cytoplasm.	Iron	89-93	cytochrome c, somatic	Homo sapiens	21-26
19103182-4	2009	We sought to characterize the potential effect of iron loading on the behavior of rMSC as well as to address the potential of rMSC to migrate when exposed to the adequate brain microenvironment.	Iron	50-54	musculin	Rattus norvegicus	82-86
19103182-6	2009	In opposition to iron-labeled rat neural stem cells (rNSC), used as a positive control, iron-labeled rMSC did not respond to the SVZ microenvironment in vivo and did not migrate, unless a mechanical lesion of the olfactory bulb was performed.	Iron	88-92	musculin	Rattus norvegicus	101-105
19103182-7	2009	This confirmed the known potential of iron-labeled rMSC to migrate toward lesions and, as far as we know, this is the first study describing such a long distance migration from the SVZ toward the olfactory bulb through the rostral migratory stream (RMS).	Iron	38-42	musculin	Rattus norvegicus	51-55
19109230-5	2009	Feeding of low- or high-iron diet was associated with appropriate ferroportin 1 and hepcidin responses in mice given histocompatible T cells, whereas mice given histoincompatible T cells showed inappropriate up-regulation of duodenal ferroportin 1 and a loss of expression of hepatic hepcidin.	Iron	24-28	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	66-79
19109230-5	2009	Feeding of low- or high-iron diet was associated with appropriate ferroportin 1 and hepcidin responses in mice given histocompatible T cells, whereas mice given histoincompatible T cells showed inappropriate up-regulation of duodenal ferroportin 1 and a loss of expression of hepatic hepcidin.	Iron	24-28	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	234-247
19123805-5	2009	Films constituted by more than nine PSS/PAH bilayers are still permeable to hexacyanoferrate(II) ions, Fe(CN)(6)4-, whatever the nature of the supporting salt anion.	Iron	103-105	PSS	Homo sapiens	36-39
19245700-10	2009	Epoetin-alfa effect on survival was weak but had statistically significant interaction with intravenous iron.	Iron	104-108	erythropoietin	Homo sapiens	0-7
18992290-1	2009	We previously demonstrated that decreasing the iron release rate of transferrin (Tf), by replacing the synergistic anion carbonate with oxalate, increases its in vitro drug carrier efficacy in HeLa cells.	Iron	47-51	transferrin	Homo sapiens	68-79
18838215-4	2009	The iron released from transferrin can activate artemisinin to generate toxic radical species to kill cells.	Iron	4-8	transferrin	Homo sapiens	23-34
18992290-1	2009	We previously demonstrated that decreasing the iron release rate of transferrin (Tf), by replacing the synergistic anion carbonate with oxalate, increases its in vitro drug carrier efficacy in HeLa cells.	Iron	47-51	transferrin	Homo sapiens	81-83
18992290-2	2009	In the current work, the utility of this strategy has been further explored by generating two Tf mutants, K206E/R632A Tf and K206E/K534A Tf, exhibiting different degrees of iron release inhibition.	Iron	173-177	transferrin	Homo sapiens	94-96
18992290-2	2009	In the current work, the utility of this strategy has been further explored by generating two Tf mutants, K206E/R632A Tf and K206E/K534A Tf, exhibiting different degrees of iron release inhibition.	Iron	173-177	transferrin	Homo sapiens	118-120
18992290-2	2009	In the current work, the utility of this strategy has been further explored by generating two Tf mutants, K206E/R632A Tf and K206E/K534A Tf, exhibiting different degrees of iron release inhibition.	Iron	173-177	transferrin	Homo sapiens	118-120
18992290-7	2009	Besides further validating our strategy of inhibiting iron release, these Tf mutants provide proof-of-principle that site-directed mutagenesis offers an alternative method for improving the drug carrier efficacy of Tf.	Iron	54-58	transferrin	Homo sapiens	215-217
19066835-0	2009	Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells.	Iron	30-34	transferrin	Homo sapiens	0-11
19026979-0	2009	Non-transferrin bound iron measurement is influenced by chelator concentration.	Iron	22-26	transferrin	Homo sapiens	4-15
19026979-2	2009	Since large variations have been described for different methods measuring non-transferrin bound iron (NTBI), we aimed to obtain more accurate values.	Iron	97-101	transferrin	Homo sapiens	79-90
19013648-4	2009	Here we have modelled the binding of aluminium, Al(III), in blood serum by the iron transport protein transferrin (Tf) as it is widely accepted that the biological fate of this non-essential metal is not adequately described by experiments, invitro and insilico, which have consistently demonstrated that at equilibrium 90% of serum Al(III) is bound by Tf.	Iron	79-83	transferrin	Homo sapiens	102-113
19013648-4	2009	Here we have modelled the binding of aluminium, Al(III), in blood serum by the iron transport protein transferrin (Tf) as it is widely accepted that the biological fate of this non-essential metal is not adequately described by experiments, invitro and insilico, which have consistently demonstrated that at equilibrium 90% of serum Al(III) is bound by Tf.	Iron	79-83	transferrin	Homo sapiens	115-117
19013648-4	2009	Here we have modelled the binding of aluminium, Al(III), in blood serum by the iron transport protein transferrin (Tf) as it is widely accepted that the biological fate of this non-essential metal is not adequately described by experiments, invitro and insilico, which have consistently demonstrated that at equilibrium 90% of serum Al(III) is bound by Tf.	Iron	79-83	transferrin	Homo sapiens	353-355
19179283-8	2009	Further bioinformatic analysis of BXD phenotypes, combined with biochemical evaluation of SERT knockout mice, nominates SERT-dependent 5-HT signaling as a major determinant of midbrain iron homeostasis that, in turn, dictates iron-regulated DA phenotypes.	Iron	185-189	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	120-124
19167957-8	2009	The best-fit linear model to predict serum iron levels included both serum transferrin receptor and C-reactive protein following log-transformation for normalization of these variables.	Iron	43-47	C-reactive protein	Homo sapiens	100-118
19166243-1	2009	Transferrin (Tf), an iron-transporting serum glycoprotein, which binds to receptors expressed at the surface of most proliferating cells with particularly high expression on erythroblasts and cancer cells, was chosen as the ligand to develop BCNU-loaded biodegradable poly(D,L-lactic acid) nanoparticles (NPs) containing a ligand, which specifically binds to glioma cells, and their anti-tumor ability was evaluated using a C6 glioma model.	Iron	21-25	transferrin	Rattus norvegicus	0-11
18835036-1	2009	Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth.	Iron	18-22	transferrin	Homo sapiens	0-11
18835036-1	2009	Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth.	Iron	51-55	transferrin	Homo sapiens	0-11
18835036-3	2009	The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18).	Iron	8-12	transferrin	Homo sapiens	27-38
25949284-3	2009	We describe a case of a young haemodialysis patient with early-stage organ dysfunction caused by hereditary haemochromatosis, in whom iron stores have successfully been depleted with phlebotomy and supplemental erythropoietin over 22 months.	Iron	134-138	erythropoietin	Homo sapiens	211-225
19268844-1	2009	INTRODUCTION: Pantothenate kinase-associated neurodegenerative disease (PKAN) is a secondary generalized dystonia associated with an accumulation of iron in the basal ganglia and increased motor cortex excitability.	Iron	149-153	pantothenate kinase 2	Homo sapiens	72-76
19379175-4	2009	To reduce the iron-overload side effects, we started an erythropoietin therapy (darbepoetin) to extend the blood transfusion interval, using 30-150 microg/week.	Iron	14-18	erythropoietin	Homo sapiens	56-70
19100788-11	2009	DFX reduces free iron levels and attenuates activation of JNK suggesting iron chelation may be useful therapy for ICH patients.	Iron	73-77	mitogen-activated protein kinase 8	Homo sapiens	58-61
19332663-3	2009	In this study, the expression of ferritin light-chain (FTL), the major iron storage protein, was investigated in rat livers after a single intravenous injection of lead nitrate.	Iron	71-75	ferritin light chain 1	Rattus norvegicus	33-53
19074761-0	2009	Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein.	Iron	22-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-93
19074761-10	2009	Thus, the stabilization of HIF-1 alpha by numerous metal ions that cannot substitute for iron in the enzyme, the alleviation of this effect by AA, and our computer modeling data support the hypothesis of iron oxidation in the hydroxylases following exposure to metal ions.	Iron	89-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-38
19074761-10	2009	Thus, the stabilization of HIF-1 alpha by numerous metal ions that cannot substitute for iron in the enzyme, the alleviation of this effect by AA, and our computer modeling data support the hypothesis of iron oxidation in the hydroxylases following exposure to metal ions.	Iron	204-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-38
19332663-3	2009	In this study, the expression of ferritin light-chain (FTL), the major iron storage protein, was investigated in rat livers after a single intravenous injection of lead nitrate.	Iron	71-75	ferritin light chain 1	Rattus norvegicus	55-58
19084504-7	2009	Taken together, our data suggest that Nbp35 plays a pivotal role in iron-sulfur cluster assembly and delivery in the plant cell cytosol as a bifunctional molecular scaffold.	Iron	68-72	nucleotide binding protein 35	Arabidopsis thaliana	38-43
19015023-6	2009	O(2)(-) inactivates mitochondrial aconitase to release iron from iron-sulfur clusters, which forms the hydroxyl radical ((.	Iron	55-59	aconitase 2	Homo sapiens	20-43
19158288-5	2009	We show that multiple mechanisms may underlie the iron accumulation in neurons and glia in SOD1(G37R) transgenic mice.	Iron	50-54	superoxide dismutase 1, soluble	Mus musculus	91-95
19158288-7	2009	We also show that treatment of SOD1(G37R) mice with an iron chelator extends life span by 5 weeks, accompanied by increased survival of spinal motor neurons and improved locomotor function.	Iron	55-59	superoxide dismutase 1, soluble	Mus musculus	31-35
18997172-3	2009	Hemojuvelin, a protein critical for maintaining appropriate levels of hepcidin, acts as a coreceptor for BMP2 and BMP4, thereby providing a link between iron homeostasis and the BMP-signaling pathway.	Iron	153-157	bone morphogenetic protein 2	Mus musculus	105-109
18997172-3	2009	Hemojuvelin, a protein critical for maintaining appropriate levels of hepcidin, acts as a coreceptor for BMP2 and BMP4, thereby providing a link between iron homeostasis and the BMP-signaling pathway.	Iron	153-157	bone morphogenetic protein 4	Mus musculus	114-118
19015023-6	2009	O(2)(-) inactivates mitochondrial aconitase to release iron from iron-sulfur clusters, which forms the hydroxyl radical ((.	Iron	65-69	aconitase 2	Homo sapiens	20-43
18815282-5	2009	Against this backdrop of subclinical iron deficiency, curcumin exerted profound 2 effects on systemic iron, inducing a dose-dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance of microcytic anisocytotic red blood cells, and decreases in spleen and liver iron content.	Iron	102-106	transferrin	Homo sapiens	185-196
19123922-1	2009	Heme oxygenase-1 (HO-1) catalyzes the oxidative degradation of heme to biliverdin, carbon monoxide, and free iron in a reaction requiring the interaction of HO-1 with NADPH-cytochrome P450 reductase (CPR).	Iron	109-113	cytochrome p450 oxidoreductase	Homo sapiens	167-198
19123922-1	2009	Heme oxygenase-1 (HO-1) catalyzes the oxidative degradation of heme to biliverdin, carbon monoxide, and free iron in a reaction requiring the interaction of HO-1 with NADPH-cytochrome P450 reductase (CPR).	Iron	109-113	cytochrome p450 oxidoreductase	Homo sapiens	200-203
19134195-5	2009	We also showed Akt/GSK-3beta signaling pathways are involved in iron nanoparticle-induced cell permeability.	Iron	64-68	AKT serine/threonine kinase 1	Homo sapiens	15-18
19134195-6	2009	The inhibition of ROS demonstrate ROS play a major role in regulating Akt/GSK-3beta - mediated cell permeability upon iron nanoparticle exposure.	Iron	118-122	AKT serine/threonine kinase 1	Homo sapiens	70-73
18815282-5	2009	Against this backdrop of subclinical iron deficiency, curcumin exerted profound 2 effects on systemic iron, inducing a dose-dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance of microcytic anisocytotic red blood cells, and decreases in spleen and liver iron content.	Iron	102-106	transferrin	Homo sapiens	185-196
18815282-5	2009	Against this backdrop of subclinical iron deficiency, curcumin exerted profound 2 effects on systemic iron, inducing a dose-dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance of microcytic anisocytotic red blood cells, and decreases in spleen and liver iron content.	Iron	102-106	transferrin	Homo sapiens	185-196
18986986-0	2009	An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.	Iron	3-7	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	33-37
18986986-2	2009	The Elp3 subunit possesses a C-terminal histone acetyltransferase (HAT) domain and an N-terminal sequence that resembles an iron-sulfur (FeS) cluster motif.	Iron	137-140	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	4-8
19960042-2	2009	Haptoglobin has a crucial role in free hemoglobin iron recovery, and exists as three major types: Hp1-1, Hp2-1 and Hp2-2.	Iron	50-54	haptoglobin	Homo sapiens	0-11
19907145-0	2009	Role of matriptase-2 (TMPRSS6) in iron metabolism.	Iron	34-38	transmembrane serine protease 6	Homo sapiens	8-20
19907145-0	2009	Role of matriptase-2 (TMPRSS6) in iron metabolism.	Iron	34-38	transmembrane serine protease 6	Homo sapiens	22-29
19907145-6	2009	In this review, we discuss the putative role of matriptase-2/TMPRSS6 in iron homeostasis.	Iron	72-76	transmembrane serine protease 6	Homo sapiens	48-60
19907145-6	2009	In this review, we discuss the putative role of matriptase-2/TMPRSS6 in iron homeostasis.	Iron	72-76	transmembrane serine protease 6	Homo sapiens	61-68
19239176-3	2009	Heme oxygenase-1 (HO-1), a stress inducible enzyme, degrades heme to biliverdin, free iron and carbon monoxide (CO), which are involved in the anti-inflammatory and antioxidant actions of HO-1.	Iron	86-90	heme oxygenase 1	Mus musculus	0-16
19239176-3	2009	Heme oxygenase-1 (HO-1), a stress inducible enzyme, degrades heme to biliverdin, free iron and carbon monoxide (CO), which are involved in the anti-inflammatory and antioxidant actions of HO-1.	Iron	86-90	heme oxygenase 1	Mus musculus	18-22
19239176-3	2009	Heme oxygenase-1 (HO-1), a stress inducible enzyme, degrades heme to biliverdin, free iron and carbon monoxide (CO), which are involved in the anti-inflammatory and antioxidant actions of HO-1.	Iron	86-90	heme oxygenase 1	Mus musculus	188-192
19008338-1	2009	Alcohol downregulates hepcidin expression in the liver leading to an increase in intestinal iron transport and liver iron storage.	Iron	92-96	hepcidin antimicrobial peptide	Rattus norvegicus	22-30
18974313-0	2009	Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium.	Iron	0-4	solute carrier family 40 member 1	Rattus norvegicus	21-34
18974313-2	2009	Ferroportin 1 (FPN1) and hephaestin (Heph) are necessary for transport of iron out of enterocytes, but it is not known whether these two proteins interact during iron absorption.	Iron	74-78	solute carrier family 40 member 1	Rattus norvegicus	0-13
18974313-2	2009	Ferroportin 1 (FPN1) and hephaestin (Heph) are necessary for transport of iron out of enterocytes, but it is not known whether these two proteins interact during iron absorption.	Iron	74-78	solute carrier family 40 member 1	Rattus norvegicus	15-19
18974313-4	2009	In rat duodenal enterocytes, within 1 h of iron feeding prominent migration of FPN1 from the apical subterminal zone to the basal subnuclear zone of the BLM occurred and increased to at least 4 h after feeding.	Iron	43-47	solute carrier family 40 member 1	Rattus norvegicus	79-83
19008338-1	2009	Alcohol downregulates hepcidin expression in the liver leading to an increase in intestinal iron transport and liver iron storage.	Iron	117-121	hepcidin antimicrobial peptide	Rattus norvegicus	22-30
18974313-7	2009	Thus the data indicate that FPN1 and Heph migrate and interact during iron feeding and suggest that dimeric FPN1 is associated with intact Heph.	Iron	70-74	solute carrier family 40 member 1	Rattus norvegicus	28-32
19008338-13	2009	Therefore, these findings suggest that alcohol acts within hepatocytes to suppress hepcidin expression and thereby influences iron homeostasis.	Iron	126-130	hepcidin antimicrobial peptide	Rattus norvegicus	83-91
18690440-6	2009	Patients with high serum ferritin levels produced significantly less IFN-gamma and IL-2, indicating the immunosuppressive effect of iron overload in beta-thalassemia patients.	Iron	132-136	interleukin 2	Homo sapiens	83-87
18570303-4	2009	INTERPRETATION: PLA2G6 mutations are associated with infantile neuroaxonal dystrophy and have been reported previously to cause early cerebellar signs, and the syndrome was classified as neurodegeneration with brain iron accumulation (type 2).	Iron	216-220	phospholipase A2 group VI	Homo sapiens	16-22
18570303-6	2009	Thus, mutations in PLA2G6 should additionally be considered in patients with adult-onset dystonia-parkinsonism even with absent iron on brain imaging.	Iron	128-132	phospholipase A2 group VI	Homo sapiens	19-25
19750232-6	2009	The treatment of RLS demands a clinical evaluation to rule out and cure causes of secondary RLS, including iron supplementation when deficient, and to eliminate the triggering factors.	Iron	107-111	RLS1	Homo sapiens	17-20
19414144-1	2009	Haemochromatosis should currently refer to hereditary iron overload disorders presenting with a definite and common phenotype characterised by normal erythropoiesis, increased transferrin saturation and ferritin and primarily parenchymal iron deposition related to innate low (but normally regulated) production of the hepatic peptide hormone hepcidin.	Iron	54-58	transferrin	Homo sapiens	176-187
18987297-5	2009	RESULTS: It was found that low levels of iron tests [either serum ferritin &lt; 100 ng/ml or transferrin saturation (TSAT) &lt; 20%] were present in most patients with reduced creatinine clearance (CrCl).	Iron	41-45	transferrin	Homo sapiens	93-104
19728850-6	2009	Midkine was correlated with CRP, erythrocyte sedimentation rate (ESR), leukocytes, platelets, interleukin-6, paraoxonase-1, albumin, transferrin, iron, hemoglobin, and hematocrit.	Iron	146-150	midkine	Homo sapiens	0-7
19154711-2	2009	While delivery of iron to cells by transferrin is well known, Li et al.	Iron	18-22	transferrin	Homo sapiens	35-46
19149565-6	2009	Increasing evidence has indicated that iron overload not only increases risks of insulin resistance and diabetes, but also causes cardiovascular diseases in non-diabetic and diabetic subjects.	Iron	39-43	insulin	Homo sapiens	81-88
19154717-7	2009	These data implicate cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.	Iron	54-58	transferrin	Homo sapiens	113-124
19154717-7	2009	These data implicate cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.	Iron	54-58	transferrin	Homo sapiens	132-143
19087156-1	2009	BACKGROUND: PLA2G6 mutations are known to be responsible for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA).	Iron	133-137	phospholipase A2 group VI	Homo sapiens	12-18
19405553-6	2009	Ferric carboxymaltose is a macromolecular ferric hydroxide carbohydrate complex, which allows for controlled delivery of iron within the cells of the reticuloendothelial system and subsequent delivery to the iron-binding proteins ferritin and transferrin, with minimal risk of release of large amounts of ionic iron in the serum.	Iron	208-212	transferrin	Homo sapiens	243-254
19405553-6	2009	Ferric carboxymaltose is a macromolecular ferric hydroxide carbohydrate complex, which allows for controlled delivery of iron within the cells of the reticuloendothelial system and subsequent delivery to the iron-binding proteins ferritin and transferrin, with minimal risk of release of large amounts of ionic iron in the serum.	Iron	208-212	transferrin	Homo sapiens	243-254
19167990-3	2009	The aim of this study was to investigate the effect of iron polyisomaltosate, an iron (Fe(3+)) compound, on serum iron, interleukin-6 (IL-6) and serotonin (5-HT) concentration, neutrophil activity, and NF-kappaB activation in peritoneal macrophages and spleen cells in rats.	Iron	55-59	interleukin 6	Rattus norvegicus	120-133
19506383-1	2009	OBJECTIVE: To evaluate the effectiveness of a stepwise use of recombinant human erythropoietin (rhEPO) in pregnant patients with severe anemia or nonresponsive to intravenously administered iron only.	Iron	190-194	erythropoietin	Homo sapiens	80-94
18815198-10	2009	They are consistent with the expression pattern of FtMt observed in mouse tissues, suggesting a FtMt protective role in cells characterized by defective iron homeostasis and respiration, such as in FRDA.	Iron	153-157	ferritin mitochondrial	Mus musculus	96-100
19200084-10	2009	Myoglobin served a major source of catalysts, ferrylmyoglobin, hematin, and/or free ionic iron, for lipid oxidation.	Iron	90-94	myoglobin	Gallus gallus	0-9
19433897-2	2009	In the present report, mice expressing human apolipoprotein E4 (associated with increased risk of AD) and apolipoprotein E3 were subjected to a diet lacking folate and vitamin E, and containing iron as a pro-oxidant.	Iron	194-198	apolipoprotein E	Homo sapiens	45-62
19817702-10	2009	Elevations in available iron affect changes in the expression of Dcytb, DMT1, ferritin, and FPN1, which further modify metal homeostasis in the lung.	Iron	24-28	cytochrome b reductase 1	Mus musculus	65-70
19817702-10	2009	Elevations in available iron affect changes in the expression of Dcytb, DMT1, ferritin, and FPN1, which further modify metal homeostasis in the lung.	Iron	24-28	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	92-96
19119918-1	2009	Heme oxygenase (HO)-1 is an inducible cytoprotective enzyme that degrades heme to iron, carbon monoxide (CO), and biliverdin, the latter two of which are thought to mediate the anti-inflammatory and antioxidant actions of HO-1.	Iron	82-86	heme oxygenase 1	Mus musculus	0-21
18992754-0	2009	Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes.	Iron	56-60	ferritin heavy chain 1	Rattus norvegicus	18-38
19119918-1	2009	Heme oxygenase (HO)-1 is an inducible cytoprotective enzyme that degrades heme to iron, carbon monoxide (CO), and biliverdin, the latter two of which are thought to mediate the anti-inflammatory and antioxidant actions of HO-1.	Iron	82-86	heme oxygenase 1	Mus musculus	222-226
19469252-1	2009	The aim of this work was to elucidate the relationship between the serum erythropoietin level, the degree of heart involvement in patients with chronic cardiac failure (CCF), characteristics of peripheral red blood cells and iron metabolism.	Iron	225-229	erythropoietin	Homo sapiens	73-87
18946492-0	2009	Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species.	Iron	184-188	transferrin	Homo sapiens	33-44
19673453-3	2009	Iron is transported into the retina by the endocytosis of iron complexed with transferrin and stored in complex with ferritin.	Iron	0-4	transferrin	Homo sapiens	78-89
19673453-3	2009	Iron is transported into the retina by the endocytosis of iron complexed with transferrin and stored in complex with ferritin.	Iron	58-62	transferrin	Homo sapiens	78-89
20161024-0	2009	Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae.	Iron	28-32	transferrin	Homo sapiens	10-21
19503841-0	2009	Persistently elevated level of IL-8 in Chlamydia trachomatis infected HeLa 229 cells is dependent on intracellular available iron.	Iron	125-129	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
19503841-3	2009	We examined the effect of iron chelators on IL-8 production in HeLa 229 (cervix epitheloid cell, CCL2) cells infected with C. trachomatis.	Iron	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
19503841-4	2009	IL-8 production was induced by Iron chelator DFO and Mimosine, however, synergy with chlamydial infection was obtained with DFO only.	Iron	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19503841-7	2009	These results indicate towards involvement of iron in chlamydia induced IL-8 production.	Iron	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
20150959-6	2009	The iron chelator o-phenanthroline effectively inhibited H(2)O(2)-induced ERK2 activation.	Iron	4-8	mitogen-activated protein kinase 1	Homo sapiens	74-78
20161024-0	2009	Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae.	Iron	76-80	transferrin	Homo sapiens	10-21
20161024-1	2009	Neisseria gonorrhoeae has the capacity to acquire iron from its human host by removing this essential nutrient from serum transferrin.	Iron	50-54	transferrin	Homo sapiens	122-133
20161024-2	2009	The transferrin binding proteins, TbpA and TbpB constitute the outer membrane receptor complex responsible for binding transferrin, extracting the tightly bound iron from the host-derived molecule, and transporting iron into the periplasmic space of this Gram-negative bacterium.	Iron	161-165	transferrin	Homo sapiens	4-15
20161024-2	2009	The transferrin binding proteins, TbpA and TbpB constitute the outer membrane receptor complex responsible for binding transferrin, extracting the tightly bound iron from the host-derived molecule, and transporting iron into the periplasmic space of this Gram-negative bacterium.	Iron	161-165	transferrin	Homo sapiens	119-130
20161024-2	2009	The transferrin binding proteins, TbpA and TbpB constitute the outer membrane receptor complex responsible for binding transferrin, extracting the tightly bound iron from the host-derived molecule, and transporting iron into the periplasmic space of this Gram-negative bacterium.	Iron	215-219	transferrin	Homo sapiens	4-15
19293593-11	2009	EPO-independent patients had low iron indices and low RET-Y levels, but a higher reticulocyte production index and albumin levels were noted.	Iron	33-37	erythropoietin	Homo sapiens	0-3
19183107-10	2009	Furthermore, up-regulation of TfR expression in leukemia cells by iron chelator deferoxamine resulted in a further increase in antisense effect (up to 79% Bcl-2 reduction in K562 at the mRNA level) and in caspase-dependent apoptosis (by approximately 3-fold) by Tf-LN.	Iron	66-70	BCL2 apoptosis regulator	Homo sapiens	155-160
18830567-0	2009	Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess.	Iron	58-62	transferrin	Homo sapiens	46-57
18830567-2	2009	The expression of these proteins potentially involved in non-transferrin iron transport across cell membranes was tested on mRNA level by quantitative real-time PCR as well as on protein level by western blot analysis in Caco-2 (colorectal carcinoma), K562 (erythroleukemia), and HEP-G2 (hepatocellular carcinoma) cells.	Iron	73-77	transferrin	Homo sapiens	61-72
18830567-3	2009	We found that changes in non-transferrin iron availability, i.e., iron deficiency and high level of non-transferrin iron, affect the expression of tested proteins in a cell type-specific manner.	Iron	41-45	transferrin	Homo sapiens	29-40
18830567-3	2009	We found that changes in non-transferrin iron availability, i.e., iron deficiency and high level of non-transferrin iron, affect the expression of tested proteins in a cell type-specific manner.	Iron	41-45	transferrin	Homo sapiens	104-115
18830567-3	2009	We found that changes in non-transferrin iron availability, i.e., iron deficiency and high level of non-transferrin iron, affect the expression of tested proteins in a cell type-specific manner.	Iron	66-70	transferrin	Homo sapiens	29-40
19212444-4	2009	In this report, we provide evidence that PrP(C) mediates cellular iron uptake and transport, and mutant PrP forms alter cellular iron levels differentially.	Iron	66-70	prion protein	Homo sapiens	41-47
19000728-1	2009	Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson"s disease, in which the misregulation of iron transporters such as divalent metal transporter (DMT1) and ferroportin1 (FP1) are involved.	Iron	9-13	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	198-210
19000728-1	2009	Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson"s disease, in which the misregulation of iron transporters such as divalent metal transporter (DMT1) and ferroportin1 (FP1) are involved.	Iron	9-13	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	212-215
19212444-9	2009	Neither PrP(C) nor the mutant PrP forms influence the rate or amount of iron released into the medium, suggesting a functional role for PrP(C) in cellular iron uptake and transport to ferritin, and dysfunction of PrP(C) as a significant contributing factor of brain iron imbalance in prion disorders.	Iron	155-159	prion protein	Homo sapiens	136-142
19212444-9	2009	Neither PrP(C) nor the mutant PrP forms influence the rate or amount of iron released into the medium, suggesting a functional role for PrP(C) in cellular iron uptake and transport to ferritin, and dysfunction of PrP(C) as a significant contributing factor of brain iron imbalance in prion disorders.	Iron	155-159	prion protein	Homo sapiens	136-142
19212444-4	2009	In this report, we provide evidence that PrP(C) mediates cellular iron uptake and transport, and mutant PrP forms alter cellular iron levels differentially.	Iron	66-70	prion protein	Homo sapiens	41-44
19212444-9	2009	Neither PrP(C) nor the mutant PrP forms influence the rate or amount of iron released into the medium, suggesting a functional role for PrP(C) in cellular iron uptake and transport to ferritin, and dysfunction of PrP(C) as a significant contributing factor of brain iron imbalance in prion disorders.	Iron	155-159	prion protein	Homo sapiens	136-142
19212444-9	2009	Neither PrP(C) nor the mutant PrP forms influence the rate or amount of iron released into the medium, suggesting a functional role for PrP(C) in cellular iron uptake and transport to ferritin, and dysfunction of PrP(C) as a significant contributing factor of brain iron imbalance in prion disorders.	Iron	155-159	prion protein	Homo sapiens	136-142
19212444-5	2009	Using human neuroblastoma cells as models, we demonstrate that over-expression of PrP(C) increases intra-cellular iron relative to non-transfected controls as indicated by an increase in total cellular iron, the cellular labile iron pool (LIP), and iron content of ferritin.	Iron	114-118	prion protein	Homo sapiens	82-88
19212444-5	2009	Using human neuroblastoma cells as models, we demonstrate that over-expression of PrP(C) increases intra-cellular iron relative to non-transfected controls as indicated by an increase in total cellular iron, the cellular labile iron pool (LIP), and iron content of ferritin.	Iron	202-206	prion protein	Homo sapiens	82-88
19212444-5	2009	Using human neuroblastoma cells as models, we demonstrate that over-expression of PrP(C) increases intra-cellular iron relative to non-transfected controls as indicated by an increase in total cellular iron, the cellular labile iron pool (LIP), and iron content of ferritin.	Iron	202-206	prion protein	Homo sapiens	82-88
19212444-5	2009	Using human neuroblastoma cells as models, we demonstrate that over-expression of PrP(C) increases intra-cellular iron relative to non-transfected controls as indicated by an increase in total cellular iron, the cellular labile iron pool (LIP), and iron content of ferritin.	Iron	202-206	prion protein	Homo sapiens	82-88
19212444-7	2009	The positive effect of PrP(C) on ferritin iron content is enhanced by stimulating PrP(C) endocytosis, and reversed by cross-linking PrP(C) on the plasma membrane.	Iron	42-46	prion protein	Homo sapiens	23-29
19212444-7	2009	The positive effect of PrP(C) on ferritin iron content is enhanced by stimulating PrP(C) endocytosis, and reversed by cross-linking PrP(C) on the plasma membrane.	Iron	42-46	prion protein	Homo sapiens	82-88
20302830-2	2009	An accumulation of redox active transition metals, including iron and copper, is likely a major generator of reactive oxidative species and other free radicals and is thought to induce a detrimental cycle of oxidative stress, amyloid-beta aggregation, and neurodegeneration.	Iron	61-65	amyloid beta precursor protein	Homo sapiens	226-238
19212444-7	2009	The positive effect of PrP(C) on ferritin iron content is enhanced by stimulating PrP(C) endocytosis, and reversed by cross-linking PrP(C) on the plasma membrane.	Iron	42-46	prion protein	Homo sapiens	82-88
19212444-8	2009	Expression of mutant PrP forms lacking the octapeptide-repeats, the membrane anchor, or carrying the pathogenic mutation PrP(102L) decreases ferritin iron content significantly relative to PrP(C) expressing cells, but the effect on cellular LIP and levels of Tf, TfR, and ferritin is complex, varying with the mutation.	Iron	150-154	prion protein	Homo sapiens	21-24
19212444-8	2009	Expression of mutant PrP forms lacking the octapeptide-repeats, the membrane anchor, or carrying the pathogenic mutation PrP(102L) decreases ferritin iron content significantly relative to PrP(C) expressing cells, but the effect on cellular LIP and levels of Tf, TfR, and ferritin is complex, varying with the mutation.	Iron	150-154	prion protein	Homo sapiens	121-124
19542657-4	2009	The iron nanotubes were fabricated in 1 M Na(2)SO(4) + 0.5 wt% NaF electrolyte by supplying constant electric currents of 50 mV/s, and holding the potential at 20, 40 and 60 V for 20 min.	Iron	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
18584923-3	2009	The insulin resistance-hepatic iron overload (IR-HIO)--also coined as the dysmetabolic iron overload syndrome--is a common cause or iron overload.	Iron	31-35	insulin	Homo sapiens	4-11
18584923-3	2009	The insulin resistance-hepatic iron overload (IR-HIO)--also coined as the dysmetabolic iron overload syndrome--is a common cause or iron overload.	Iron	87-91	insulin	Homo sapiens	4-11
18584923-3	2009	The insulin resistance-hepatic iron overload (IR-HIO)--also coined as the dysmetabolic iron overload syndrome--is a common cause or iron overload.	Iron	87-91	insulin	Homo sapiens	4-11
19052911-11	2009	On the other hand, a relatively small quantity of Fe is present in tissue myoglobin, catalase, peroxidases, and cytochromes.	Iron	50-52	catalase	Camelus dromedarius	85-93
19717922-4	2009	The pH in Fe electrode system elevate higher than that in Al electrode because the As(V) removal substitutes more OH position in Fe-hydroxide than that in Al-hydroxide.	Iron	10-12	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-88
19717922-0	2009	Treatment of As(V) and As(III) by electrocoagulation using Al and Fe electrode.	Iron	66-68	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	13-18
19058322-11	2008	An increase in the iron saturation of plasma transferrin leads to displacement of TfR1 from HFE and assembly of the putative iron-sensing complex.	Iron	19-23	transferrin	Homo sapiens	45-56
18849566-4	2008	Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme.	Iron	48-52	cystathionine beta-synthase	Homo sapiens	123-126
18957412-9	2008	These results show that despite considerable divergence from the yeast Cfd1-Nbp35 Fe-S scaffold complex, AtNBP35 has retained similar Fe-S cluster binding and transfer properties and performs an essential function.	Iron	82-86	nucleotide binding protein 35	Arabidopsis thaliana	105-112
18957412-9	2008	These results show that despite considerable divergence from the yeast Cfd1-Nbp35 Fe-S scaffold complex, AtNBP35 has retained similar Fe-S cluster binding and transfer properties and performs an essential function.	Iron	134-138	nucleotide binding protein 35	Arabidopsis thaliana	105-112
19058322-11	2008	An increase in the iron saturation of plasma transferrin leads to displacement of TfR1 from HFE and assembly of the putative iron-sensing complex.	Iron	125-129	transferrin	Homo sapiens	45-56
18986169-0	2008	Studies on the mechanism of catalysis of iron-sulfur cluster transfer from IscU[2Fe2S] by HscA/HscB chaperones.	Iron	41-45	iron-sulfur cluster assembly enzyme	Homo sapiens	75-79
19090990-2	2008	Iron was further demonstrated to modulate expression of the Alzheimer"s amyloid precursor holo-protein (APP) by a mechanism similar to that of regulation of ferritin-L and -H mRNA translation through an iron-responsive element (IRE) in their 5" untranslated regions (UTRs).	Iron	0-4	amyloid beta precursor protein	Homo sapiens	72-102
19090990-2	2008	Iron was further demonstrated to modulate expression of the Alzheimer"s amyloid precursor holo-protein (APP) by a mechanism similar to that of regulation of ferritin-L and -H mRNA translation through an iron-responsive element (IRE) in their 5" untranslated regions (UTRs).	Iron	203-207	amyloid beta precursor protein	Homo sapiens	72-102
19090990-4	2008	The first is the physiological aspect: a compensatory neuroprotective response of amyloid-beta protein (Abeta) in reducing iron-induced neurotoxicity.	Iron	123-127	amyloid beta precursor protein	Homo sapiens	104-109
18819919-0	2008	Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest.	Iron	35-39	tumor protein p53	Homo sapiens	59-62
18819919-2	2008	In this report we investigate changes in proteins of iron metabolism during p53-mediated replicative arrest.	Iron	53-57	tumor protein p53	Homo sapiens	76-79
18819919-9	2008	Collectively, these results suggest that p53 may induce cell cycle arrest not only by well described mechanisms involving the induction of cyclin-dependent kinase inhibitors but also by the recruitment of pathways that reduce the availability of intracellular iron.	Iron	260-264	tumor protein p53	Homo sapiens	41-44
18986169-1	2008	The HscA/HscB chaperone/cochaperone system accelerates transfer of iron-sulfur clusters from the FeS-scaffold protein IscU (IscU(2)[2Fe2S], holo-IscU) to acceptor proteins in an ATP-dependent manner.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	118-122
18986169-1	2008	The HscA/HscB chaperone/cochaperone system accelerates transfer of iron-sulfur clusters from the FeS-scaffold protein IscU (IscU(2)[2Fe2S], holo-IscU) to acceptor proteins in an ATP-dependent manner.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	124-138
18986169-1	2008	The HscA/HscB chaperone/cochaperone system accelerates transfer of iron-sulfur clusters from the FeS-scaffold protein IscU (IscU(2)[2Fe2S], holo-IscU) to acceptor proteins in an ATP-dependent manner.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	124-128
18986169-8	2008	These results suggest that acceleration of iron-sulfur cluster transfer involves a structural change in the IscU(2)[2Fe2S] complex during the T --&gt; R transition of HscA accompanying ATP hydrolysis.	Iron	43-47	iron-sulfur cluster assembly enzyme	Homo sapiens	108-122
19010258-4	2008	These studies provide suggestive evidence of the ability of IV iron to reduce ESA requirements and maintain improved Hb levels in anemic hemodialysis patients with serum ferritin levels of 500 to 1,200 ng/mL and transferrin saturations of 25% or less.	Iron	63-67	transferrin	Homo sapiens	212-223
18951467-3	2008	We demonstrate that low urinary hepcidin, likely due to impaired iron delivery to erythroid cells via the transferrin cycle pathway over time, may be the mechanism for iron loading.	Iron	168-172	transferrin	Homo sapiens	106-117
19010259-4	2008	These issues prompted an analysis of the Dialysis Patients" Response to IV Iron with Elevated Ferritin (DRIVE) studies to determine the cost savings associated with the ESA-sparing effects of intravenous (IV) iron, which showed that administering a 1-g course of IV iron (sodium ferric gluconate) to ESA-treated patients with increased serum ferritin levels and low transferrin saturations, compared with administering an ESA alone, resulted in decreased ESA requirements.	Iron	209-213	transferrin	Homo sapiens	366-377
19010259-5	2008	These findings suggest that a single dose of IV iron in patients with high serum ferritin levels and low transferrin saturations as defined in DRIVE represents a potential tactic for improving treatment efficiency in a bundled reimbursement environment.	Iron	48-52	transferrin	Homo sapiens	105-116
19021541-1	2008	The essential metals iron, zinc and copper deposit near the Abeta (amyloid beta-peptide) plaques in the brain cortex of AD (Alzheimer"s disease) patients.	Iron	21-25	amyloid beta precursor protein	Homo sapiens	60-87
19076458-5	2008	Our group and others have implicated the transcriptional activator HIF-1 in some of the salutary effects of iron chelation-induced PHD inhibition.	Iron	108-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
18775801-9	2008	An unexpected observation was the synergistic effect of BMPs and IL-6 on hepcidin-25 secretion, which points towards cross-talk between iron and inflammatory stimuli.	Iron	136-140	interleukin 6	Homo sapiens	65-69
19021532-0	2008	The role of Dcytb in iron metabolism: an update.	Iron	21-25	cytochrome b reductase 1	Mus musculus	12-17
19021532-6	2008	Studies underway in Dcytb-knockout mice reveal that Dcytb is the only iron-regulated ferric reductase in the duodenal mucosa and that loss of Dcytb affects iron absorption.	Iron	70-74	cytochrome b reductase 1	Mus musculus	52-57
19021532-6	2008	Studies underway in Dcytb-knockout mice reveal that Dcytb is the only iron-regulated ferric reductase in the duodenal mucosa and that loss of Dcytb affects iron absorption.	Iron	70-74	cytochrome b reductase 1	Mus musculus	52-57
19021540-4	2008	We now know that (i) Cp regulates the efficiency of iron efflux, (ii) Cp stabilizes ferroportin membrane expression, (iii) GPI (glycosylphosphatidylinositol)-linked Cp is the predominant form expressed in brain, (iv) Cp functions as a ferroxidase and regulates the oxidation of Fe(2+) to Fe(3+), (v) Cp does not bind to transferrin directly, and (vi) Cp is one member of a family of mammalian MCOs, which includes hephaestin.	Iron	52-56	transferrin	Homo sapiens	320-331
19021541-7	2008	The APP IRE is homologous with the canonical IRE RNA stem-loop that binds the iron regulatory proteins (IRP1 and IRP2) to control intracellular iron homoeostasis by modulating ferritin mRNA translation and transferrin receptor mRNA stability.	Iron	78-82	iron responsive element binding protein 2	Homo sapiens	113-117
19021546-4	2008	In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control.	Iron	81-85	transferrin	Homo sapiens	63-74
19021568-1	2008	Transferrin receptor 1 (R) and human serum transferrin (T) are the two main actors in iron acquisition by the cell.	Iron	86-90	transferrin	Homo sapiens	0-11
19021568-1	2008	Transferrin receptor 1 (R) and human serum transferrin (T) are the two main actors in iron acquisition by the cell.	Iron	86-90	transferrin	Homo sapiens	43-54
19021568-2	2008	R binds TFe(2) (iron-loaded transferrin), which allows its internalization in the cytoplasm by endocytosis.	Iron	16-20	transferrin	Homo sapiens	28-39
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	23-27	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	292-295
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	23-27	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	301-304
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	23-27	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	301-304
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	23-27	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	301-304
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	23-27	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	328-335
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	396-400	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	292-295
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	396-400	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	301-304
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	396-400	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	301-304
18405401-8	2008	Low serum albumin was related to age, use of anticonvulsants and/or major tranquilisers, use of other medications, high C-reactive protein (CRP), high zinc sulfate turbidity test (ZTT), low serum Hb and low serum Fe among men; among women, high CRP and high ZTT were related to low serum albumin.	Iron	213-215	albumin	Homo sapiens	10-17
18771759-3	2008	Iron availability to cells also depends on haptoglobin (Hp) phenotypes.	Iron	0-4	haptoglobin	Homo sapiens	43-54
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	396-400	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	301-304
18771759-9	2008	Lower serum iron was associated with elevated transferrin in patients with Hp 1.1; moreover patients had relative iron deficiency compared with the controls and fractured patients had higher level of oxLDL.	Iron	12-16	transferrin	Homo sapiens	46-57
19021568-4	2008	In order to follow the iron-acquisition pathway, these metals should obey at least two essential rules: (i) formation of a strong complex with T; and (ii) interaction of this complex with R. In the present paper, we propose a general mechanism for the interaction of five metal-loaded Ts [Fe(III), Al(III), Bi(III), Ga(III) and Co(III)] with R and we discuss their potential incorporation by the iron-acquisition pathway.	Iron	396-400	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	328-335
19046249-5	2008	CONCLUSIONS: Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism.	Iron	104-108	insulin	Homo sapiens	24-31
18976966-6	2008	The expression of matriptase-2 mutants in zebrafish results in anemia, confirming the matriptase-2 role in iron metabolism and its interaction with HJV.	Iron	107-111	transmembrane serine protease 6	Homo sapiens	18-30
18976966-6	2008	The expression of matriptase-2 mutants in zebrafish results in anemia, confirming the matriptase-2 role in iron metabolism and its interaction with HJV.	Iron	107-111	transmembrane serine protease 6	Homo sapiens	86-98
18557926-7	2008	Akt/ERK signalling but not p38 activation was abolished in the presence of the iron chelator desferroxamine that blocks formation of hydroxyl ( OH) radicals.	Iron	79-83	AKT serine/threonine kinase 1	Homo sapiens	0-3
18557926-7	2008	Akt/ERK signalling but not p38 activation was abolished in the presence of the iron chelator desferroxamine that blocks formation of hydroxyl ( OH) radicals.	Iron	79-83	mitogen-activated protein kinase 3	Homo sapiens	4-7
18815225-3	2008	The aim of this study was to evaluate structural and functional properties of confluent b30 BeWo cell layers grown in bicameral chambers, focusing on the potential application for studying receptor-mediated uptake and transport of transferrin (Tf)-bound iron (Fe-Tf).	Iron	254-258	transferrin	Homo sapiens	231-242
19014383-2	2008	For most cell types transferrin is the major iron delivery protein, yet neither transferrin receptor protein nor mRNA are detectable in mature oligodendrocytes.	Iron	45-49	transferrin	Rattus norvegicus	20-31
18784075-6	2008	Increments in mitochondrial iron uptake induced stepwise assembly of Yfh1 species ranging from trimer to &gt; or = 24-mer, independent of interactions between Yfh1 and its major iron-binding partners, Isu1/Nfs1 or aconitase.	Iron	28-32	cysteine desulfurase	Saccharomyces cerevisiae S288C	206-210
19002083-14	2008	A number of proteins is involved in iron metabolism including: ferritin, transferrin,transferrin receptor, divalent metal transporter (DMT1), cytochrome b, ferroportin, hephaestin, hepcidin and lactoferrin (LF).	Iron	36-40	transferrin	Homo sapiens	73-84
19002083-14	2008	A number of proteins is involved in iron metabolism including: ferritin, transferrin,transferrin receptor, divalent metal transporter (DMT1), cytochrome b, ferroportin, hephaestin, hepcidin and lactoferrin (LF).	Iron	36-40	transferrin	Homo sapiens	85-96
18937498-3	2008	We have determined the 1.9 A resolution crystal structure of the catalytic domain (Delta1-100/Delta415-445) of chicken TPH isoform 1 (TPH1) in complex with the tryptophan substrate and an iron-bound imidazole.	Iron	188-192	tryptophan hydroxylase 1	Gallus gallus	119-132
18937498-3	2008	We have determined the 1.9 A resolution crystal structure of the catalytic domain (Delta1-100/Delta415-445) of chicken TPH isoform 1 (TPH1) in complex with the tryptophan substrate and an iron-bound imidazole.	Iron	188-192	tryptophan hydroxylase 1	Gallus gallus	134-138
18716131-1	2008	Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release.	Iron	150-154	tumor necrosis factor	Homo sapiens	17-38
18716131-1	2008	Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release.	Iron	150-154	tumor necrosis factor	Homo sapiens	46-55
18716131-1	2008	Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release.	Iron	150-154	tumor necrosis factor	Homo sapiens	107-116
18716131-1	2008	Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release.	Iron	181-185	tumor necrosis factor	Homo sapiens	17-38
18716131-1	2008	Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release.	Iron	181-185	tumor necrosis factor	Homo sapiens	46-55
18716131-1	2008	Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release.	Iron	181-185	tumor necrosis factor	Homo sapiens	107-116
18716131-6	2008	Thus, TNF appears to be a risk factor for iron deficiency and IDA in children in a malaria-endemic environment and this is likely to be due to a TNF-alpha-induced block in iron absorption.	Iron	42-46	tumor necrosis factor	Homo sapiens	6-9
18716131-6	2008	Thus, TNF appears to be a risk factor for iron deficiency and IDA in children in a malaria-endemic environment and this is likely to be due to a TNF-alpha-induced block in iron absorption.	Iron	42-46	tumor necrosis factor	Homo sapiens	145-154
18687678-2	2008	High levels of UCP2 mRNA were recently found in erythroid cells where UCP2 is hypothesized to function as a facilitator of heme synthesis and iron metabolism by reducing ROS production.	Iron	142-146	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	15-19
18687678-2	2008	High levels of UCP2 mRNA were recently found in erythroid cells where UCP2 is hypothesized to function as a facilitator of heme synthesis and iron metabolism by reducing ROS production.	Iron	142-146	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	70-74
21581137-1	2008	In the title salt, [Fe(3)(C(2)H(6)NS)(6)](ClO(4))(3), the trinuclear cation lies on a special position of site symmetry; the central Fe atom is coordinated by six thiol-ate groups from the two flanking fac-(S)-[Fe(C(2)H(6)NS)(3)] units.	Iron	20-22	FA complementation group C	Homo sapiens	202-205
18815225-3	2008	The aim of this study was to evaluate structural and functional properties of confluent b30 BeWo cell layers grown in bicameral chambers, focusing on the potential application for studying receptor-mediated uptake and transport of transferrin (Tf)-bound iron (Fe-Tf).	Iron	254-258	transferrin	Homo sapiens	244-246
18815225-3	2008	The aim of this study was to evaluate structural and functional properties of confluent b30 BeWo cell layers grown in bicameral chambers, focusing on the potential application for studying receptor-mediated uptake and transport of transferrin (Tf)-bound iron (Fe-Tf).	Iron	260-262	transferrin	Homo sapiens	244-246
18941350-7	2008	Intravenous iron may be beneficial for patients with hemoglobin less than 11 g/dl and transferrin saturation less than 25% despite elevated ferritin (500-1200 ng/ml).	Iron	12-16	transferrin	Homo sapiens	86-97
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	31-35	interleukin 10	Mus musculus	70-75
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	31-35	interleukin 10	Mus musculus	168-173
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	243-247	interleukin 10	Mus musculus	70-75
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	243-247	interleukin 10	Mus musculus	168-173
18775775-1	2008	Iron release from intravenous iron formulations can increase both non-transferrin-bound iron (NTBI) and oxidative stress.	Iron	0-4	transferrin	Homo sapiens	70-81
19054085-0	2008	Loss of the oxidative stress regulator OxyR in Pseudomonas aeruginosa PAO1 impairs growth under iron-limited conditions.	Iron	96-100	transcriptional regulator	Pseudomonas aeruginosa PAO1	39-43
19054085-4	2008	Inactivation of the oxyR gene in Pseudomonas fluorescens ATCC 17400 and in P. aeruginosa PAO1 impairs pyoverdine-mediated iron uptake.	Iron	122-126	transcriptional regulator	Pseudomonas aeruginosa PAO1	20-24
19054085-6	2008	Growth of the oxyR mutant in low- or high-iron media is also impaired at a low, but not at a high inoculum density.	Iron	42-46	transcriptional regulator	Pseudomonas aeruginosa PAO1	14-18
18775775-1	2008	Iron release from intravenous iron formulations can increase both non-transferrin-bound iron (NTBI) and oxidative stress.	Iron	30-34	transferrin	Homo sapiens	70-81
18775775-1	2008	Iron release from intravenous iron formulations can increase both non-transferrin-bound iron (NTBI) and oxidative stress.	Iron	88-92	transferrin	Homo sapiens	70-81
18951820-4	2008	For myelodysplasias, therapeutic changes including oral iron chelators and more intensive transfusion policies will likely result in an increase of PRC requirements, a situation shared by sickle-cell disease.	Iron	56-60	PPARG related coactivator 1	Homo sapiens	148-151
18615641-2	2008	Thy1 was identified in a gene expression analysis as iron responsive, and subsequent cell culture and animal models of iron deficiency expanded this finding to the protein.	Iron	53-57	thymus cell antigen 1, theta	Mus musculus	0-4
18579343-7	2008	Pre-treatment of rats with Fe(TPPS) significantly attenuated or prevented all these markers at both post-lesion times tested, except for GFAP immunoreactivity at 7 days post-lesion and iNOS immunoreactivity at 1 day post-lesion.	Iron	27-29	nitric oxide synthase 2	Rattus norvegicus	185-189
18974579-7	2008	In conclusion, hemodialysis patients with refractory anemia and adequate iron stores, vitamin C improved responsiveness to Epo by augmenting iron mobilization and possibly via antioxidant effect.	Iron	141-145	erythropoietin	Homo sapiens	123-126
19094444-1	2008	Catalase (antioxidant enzyme) activity in erythrocytes and serum levels of trace elements (copper, iron, zinc), heavy metals (cadmium, cobalt) and vitamins A (retinol), D (cholecalciferol) and E (alpha-tocopherol) were measured in 145 subjects comprising 47 pre-eclamptic pregnant women (PE), 48 healthy pregnant women (HP) and 50 healthy non-pregnant controls (NP).	Iron	99-103	catalase	Homo sapiens	0-8
19260610-10	2008	iron-loading dose of 500 mg to 1,000 mg of sodium ferric gluconate for patients on hemodialysis receiving at least 18,000 units/week of Epoetin, had a serum ferritin less than 1,500 ng/mL and a transferrin saturation (TSAT) less than 30%, and had not received a loading dose of i.v.	Iron	0-4	erythropoietin	Homo sapiens	136-143
19260610-10	2008	iron-loading dose of 500 mg to 1,000 mg of sodium ferric gluconate for patients on hemodialysis receiving at least 18,000 units/week of Epoetin, had a serum ferritin less than 1,500 ng/mL and a transferrin saturation (TSAT) less than 30%, and had not received a loading dose of i.v.	Iron	0-4	transferrin	Homo sapiens	194-205
18809082-16	2008	As part of the method validation the relative stability of complexes of albumin, transferrin and citrate with Mn, Fe, Cu and Zn was investigated.	Iron	114-116	transferrin	Homo sapiens	81-92
18655771-1	2008	Iron regulatory protein (IRP)-1 and IRP2 inhibit ferritin synthesis by binding to an iron responsive element in the 5"-untranslated region of its mRNA.	Iron	85-89	iron responsive element binding protein 2	Homo sapiens	36-40
18655771-7	2008	These results suggest that iron regulatory proteins, particularly IRP2, increase neuronal vulnerability to oxidative injury.	Iron	27-31	iron responsive element binding protein 2	Homo sapiens	66-70
18664566-2	2008	We previously demonstrated that the cytosolic and mitochondrial iron-sulfur (Fe/S) cluster assembly machineries termed CIA and ISC, including a cysteine desulfurase called Nfs1, were essential for the s(2) modification.	Iron	77-79	cysteine desulfurase	Saccharomyces cerevisiae S288C	172-176
18799783-1	2008	OBJECTIVE: Mutations in the gene encoding phospholipase A(2) group VI (PLA2G6) are associated with two childhood neurologic disorders: infantile neuroaxonal dystrophy (INAD) and idiopathic neurodegeneration with brain iron accumulation (NBIA).	Iron	218-222	phospholipase A2 group VI	Homo sapiens	42-69
18799783-1	2008	OBJECTIVE: Mutations in the gene encoding phospholipase A(2) group VI (PLA2G6) are associated with two childhood neurologic disorders: infantile neuroaxonal dystrophy (INAD) and idiopathic neurodegeneration with brain iron accumulation (NBIA).	Iron	218-222	phospholipase A2 group VI	Homo sapiens	71-77
18799783-11	2008	PLA2G6 mutations are associated with nearly all cases of classic infantile neuroaxonal dystrophy but a minority of cases of idiopathic neurodegeneration with brain iron accumulation, and genotype correlates with phenotype.	Iron	164-168	phospholipase A2 group VI	Homo sapiens	0-6
18715869-0	2008	The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.	Iron	129-133	DExD/H-box ATP-dependent RNA helicase DHH1	Saccharomyces cerevisiae S288C	42-46
18715869-6	2008	We demonstrate that the degradation of succinate dehydrogenase SDH4 mRNA, a known target of Cth2 on iron-deficient conditions, depends on Dhh1.	Iron	100-104	DExD/H-box ATP-dependent RNA helicase DHH1	Saccharomyces cerevisiae S288C	138-142
18794901-0	2008	The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.	Iron	72-76	mucolipin TRP cation channel 1	Homo sapiens	45-51
18794901-4	2008	Because aberrant iron metabolism may cause neural and retinal degeneration, it may be a primary cause of ML4 phenotypes.	Iron	17-21	mucolipin TRP cation channel 1	Homo sapiens	105-108
18794901-8	2008	By measuring radiolabelled iron uptake, by monitoring the levels of cytosolic and intralysosomal iron and by directly patch-clamping the late endosomal and lysosomal membrane, here we show that TRPML1 functions as a Fe(2+) permeable channel in late endosomes and lysosomes.	Iron	27-31	mucolipin TRP cation channel 1	Homo sapiens	194-200
18794901-8	2008	By measuring radiolabelled iron uptake, by monitoring the levels of cytosolic and intralysosomal iron and by directly patch-clamping the late endosomal and lysosomal membrane, here we show that TRPML1 functions as a Fe(2+) permeable channel in late endosomes and lysosomes.	Iron	97-101	mucolipin TRP cation channel 1	Homo sapiens	194-200
18794901-12	2008	Our results indicate that impaired iron transport may contribute to both haematological and degenerative symptoms of ML4 patients.	Iron	35-39	mucolipin TRP cation channel 1	Homo sapiens	117-120
18755804-0	2008	Interrelationships between circulating gastrin and iron status in mice and humans.	Iron	51-55	gastrin	Mus musculus	39-46
18684194-7	2008	In both control and iron-depleted patients, a positive correlation was found between the decrease of antibacterial effect and the increase of both serum iron and transferrin saturation.	Iron	20-24	transferrin	Homo sapiens	162-173
18684194-8	2008	CONCLUSIONS: These results (a) support the view that chronic iron overload decreases serum antibacterial effect against Salmonella enterica Typhimurium LT2, (b) favor the interest of including, besides serum ferritinemia, serum transferrin saturation levels as a further criterion for iron-depletive treatment efficacy, and (c) provide an argument for not discouraging the use of blood from iron-depleted hemochromatosis patients for transfusion.	Iron	61-65	transferrin	Homo sapiens	228-239
18755804-1	2008	The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron homeostasis.	Iron	151-155	gastrin	Mus musculus	107-114
18755804-1	2008	The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron homeostasis.	Iron	151-155	gastrin	Mus musculus	107-114
18755804-1	2008	The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron homeostasis.	Iron	233-237	gastrin	Mus musculus	42-49
18755804-1	2008	The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron homeostasis.	Iron	233-237	gastrin	Mus musculus	107-114
18755804-1	2008	The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron homeostasis.	Iron	233-237	gastrin	Mus musculus	107-114
18755804-2	2008	This study tested the hypothesis that gastrin and iron status are interrelated by measurement of iron homeostasis in mice and humans with abnormal circulating gastrin concentrations.	Iron	97-101	gastrin	Mus musculus	38-45
18755804-4	2008	Iron status was measured by standard methods in the same mice and in hypergastrinemic humans with multiple endocrine neoplasia type 1 (MEN-1).	Iron	0-4	menin 1	Homo sapiens	98-133
18755804-10	2008	Our data indicate that, in juvenile animals when iron demand is high, circulating gastrin concentrations may alter iron status by a CCK2R-independent mechanism.	Iron	49-53	gastrin	Mus musculus	82-89
18555026-9	2008	In addition, the enzymatic site of cytochrome c was sensitive to the attack of both superoxide and hydroxyl radicals as observed through the reduction of Fe(3+), the degradation of the protoporphyrin IX and the oxidative disruption of the Met80-Fe(3+) bond.	Iron	154-156	cytochrome c, somatic	Homo sapiens	35-47
18755804-10	2008	Our data indicate that, in juvenile animals when iron demand is high, circulating gastrin concentrations may alter iron status by a CCK2R-independent mechanism.	Iron	115-119	gastrin	Mus musculus	82-89
18304722-0	2008	Changes in non-transferrin-bound iron (NTBI) in pregnant women on iron supplements.	Iron	33-37	transferrin	Homo sapiens	15-26
18665838-7	2008	We demonstrate for the first time that Gata1 expression in developing erythroid precursors is decreased in iron deficiency, and is decreased further in combined iron and HRI deficiencies.	Iron	107-111	GATA binding protein 1	Homo sapiens	39-44
18554871-3	2008	The haptoglobin HP2-2 genotype has been associated with idiopathic generalized epilepsies and altered iron metabolism in children with alpha-thalassaemia can potentially interfere with neurotransmission and increase the risk of seizures.	Iron	102-106	haptoglobin	Homo sapiens	4-15
18667223-2	2008	Recently, ferritin and apoferritin (ferritin devoid of the iron core), have been employed as chemically addressable nanoscale building blocks for functional materials development.	Iron	59-63	ferritin heavy chain	Equus caballus	23-34
18672098-7	2008	DNA-PK and ATM are required, to different extents, for the partial repair of Fe-induced DNA damage.	Iron	77-79	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	0-6
18672098-13	2008	Surprisingly, these events occur even in the absence of ATM kinase implying that ATR may be a major responder to the complex DNA damage inflicted by Fe ions.	Iron	149-151	ATR serine/threonine kinase	Homo sapiens	81-84
18725184-11	2008	In the patients with the homozygous HJV mutation, iron loading revealed high serum ferritin concentration with accompanying elevated transferrin iron saturation.	Iron	50-54	transferrin	Homo sapiens	133-144
18725184-11	2008	In the patients with the homozygous HJV mutation, iron loading revealed high serum ferritin concentration with accompanying elevated transferrin iron saturation.	Iron	145-149	transferrin	Homo sapiens	133-144
18304722-0	2008	Changes in non-transferrin-bound iron (NTBI) in pregnant women on iron supplements.	Iron	66-70	transferrin	Homo sapiens	15-26
19017117-6	2008	Gene chip and real-time polymerase chain reaction analyses indicated that the expression of two Fe-related genes encoding an iron transporter AtIRT1 and an iron storage protein ferritin AtFER1 might be negatively regulated by MxMYB1 as the expression levels of these genes were lower in MxMYB1 expressing transgenic Arabidopsis plants as compared with wild type plants under both Fe-normal and Fe-deficient conditions.	Iron	96-98	ferretin 1	Arabidopsis thaliana	186-192
18603562-0	2008	A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron.	Iron	122-126	transmembrane serine protease 6	Homo sapiens	18-25
19697763-1	2008	The performance of electrocoagulation method with aluminium, iron and hybrid Al/Fe sacrificial anodes in the treatment of arsenite [As(III)] and arsenate [As(V)] in pharmaceutical industrial effluents was investigated.	Iron	80-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	154-160
18806096-8	2008	Brain Fe deficit and brain transferrin receptor enhancement were eliminated in the Cu- group injected with Fe compared with Cu-S pups, supporting an association between low plasma Fe and low brain Fe.	Iron	107-109	transferrin	Rattus norvegicus	27-38
18806096-8	2008	Brain Fe deficit and brain transferrin receptor enhancement were eliminated in the Cu- group injected with Fe compared with Cu-S pups, supporting an association between low plasma Fe and low brain Fe.	Iron	107-109	transferrin	Rattus norvegicus	27-38
18806096-8	2008	Brain Fe deficit and brain transferrin receptor enhancement were eliminated in the Cu- group injected with Fe compared with Cu-S pups, supporting an association between low plasma Fe and low brain Fe.	Iron	107-109	transferrin	Rattus norvegicus	27-38
19017117-6	2008	Gene chip and real-time polymerase chain reaction analyses indicated that the expression of two Fe-related genes encoding an iron transporter AtIRT1 and an iron storage protein ferritin AtFER1 might be negatively regulated by MxMYB1 as the expression levels of these genes were lower in MxMYB1 expressing transgenic Arabidopsis plants as compared with wild type plants under both Fe-normal and Fe-deficient conditions.	Iron	125-129	ferretin 1	Arabidopsis thaliana	186-192
19017117-6	2008	Gene chip and real-time polymerase chain reaction analyses indicated that the expression of two Fe-related genes encoding an iron transporter AtIRT1 and an iron storage protein ferritin AtFER1 might be negatively regulated by MxMYB1 as the expression levels of these genes were lower in MxMYB1 expressing transgenic Arabidopsis plants as compared with wild type plants under both Fe-normal and Fe-deficient conditions.	Iron	380-382	ferretin 1	Arabidopsis thaliana	186-192
18848136-0	2008	Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque.	Iron	61-65	haptoglobin	Homo sapiens	0-11
18809098-5	2008	Newer agents under active investigation include continuous erythropoietin receptor activator (CERA) or proline hydroxylase inhibitors that increase hypoxia-inducible factor-1 (HIF-1), thereby stimulating Epo production and iron availability and supply.	Iron	223-227	erythropoietin	Homo sapiens	59-73
18809098-5	2008	Newer agents under active investigation include continuous erythropoietin receptor activator (CERA) or proline hydroxylase inhibitors that increase hypoxia-inducible factor-1 (HIF-1), thereby stimulating Epo production and iron availability and supply.	Iron	223-227	hypoxia inducible factor 1 subunit alpha	Homo sapiens	176-181
18657303-5	2008	Analysis of correlation between lead and other trace elements in milk from lactating cows with the blood lead level&gt;0.20 microg/ml (n=79) revealed a significant negative correlations between milk iron and milk lead (r=-0.273, P=0.015).	Iron	199-203	Weaning weight-maternal milk	Bos taurus	194-198
18657303-5	2008	Analysis of correlation between lead and other trace elements in milk from lactating cows with the blood lead level&gt;0.20 microg/ml (n=79) revealed a significant negative correlations between milk iron and milk lead (r=-0.273, P=0.015).	Iron	199-203	Weaning weight-maternal milk	Bos taurus	194-198
18848136-1	2008	OBJECTIVES: We sought to test the hypothesis that haptoglobin (Hp) genotype is a determinant of the amount of iron in the atherosclerotic plaque.	Iron	110-114	haptoglobin	Homo sapiens	50-61
18939629-7	2008	However, both bovine hemoglobin and transferrin supported growth of O. rhinotracheale serotype C. Four immunoreactive proteins involved in iron acquisition were identified in an O. rhinotracheale membrane extract by using mass spectrometry.	Iron	139-143	serotransferrin	Bos taurus	36-47
18681435-7	2008	The electronic absorption spectrum and nu(Fe-CO)/nu(CO) vibrational frequencies of the CO-heme-HSA-ibuprofen complex, together with the observation of a Fe-His Raman mode at 218 cm(-1) upon photolysis of the CO complex and the low spin EPR g values indicate that a His residue is one of the low spin axial ligands, the sixth ligand probably being Tyr161.	Iron	153-155	albumin	Homo sapiens	95-98
18712936-4	2008	The reason why ICA family members have lost the ability to bind iron is potentially related to acquiring a new function(s), one of which is inhibition of certain carbonic anhydrase (CA) isoforms.	Iron	64-68	inhibitor of carbonic anhydrase	Mus musculus	15-18
18712936-5	2008	A recombinant mutant of the mICA (W124R/S188Y) was created with the goal of restoring the ligands required for both anion (Arg124) and iron (Tyr188) binding in the N-lobe.	Iron	135-139	inhibitor of carbonic anhydrase	Mus musculus	28-32
18712936-9	2008	Induction of specific iron binding implies that (1) the structure of mICA resembles those of other TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron binds.	Iron	22-26	inhibitor of carbonic anhydrase	Mus musculus	69-73
18712936-9	2008	Induction of specific iron binding implies that (1) the structure of mICA resembles those of other TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron binds.	Iron	192-196	inhibitor of carbonic anhydrase	Mus musculus	69-73
18768801-8	2008	Our data suggest that NF-kappaB contributes to thyroid tumor cell survival by controlling iron uptake via NGAL.	Iron	90-94	nuclear factor kappa B subunit 1	Homo sapiens	22-31
17916327-1	2008	To fulfill their nutritional requirement for iron, bacteria utilize various iron sources which include the host proteins transferrin and lactoferrin, heme, and low molecular weight iron chelators termed siderophores.	Iron	76-80	transferrin	Homo sapiens	121-132
17916327-1	2008	To fulfill their nutritional requirement for iron, bacteria utilize various iron sources which include the host proteins transferrin and lactoferrin, heme, and low molecular weight iron chelators termed siderophores.	Iron	76-80	transferrin	Homo sapiens	121-132
18703380-5	2008	Many studies show a positive effect of Erythropoietin (EPO) or its" derivatives when administered in combination with oral or IV iron, with improvements in left and right ventricular systolic and diastolic function, dilation and hypertrophy and renal function.	Iron	129-133	erythropoietin	Homo sapiens	39-53
18590715-4	2008	The identity and purity of the fractions was evaluated by HPLC, using specific absorbance measurement of the iron-transferrin complex at 470 nm, and by mass spectrometry, using ESI Q-Tof MS. A primary candidate reference material was prepared by mixing isolated fractions in transferrin-free plasma in a proportion similar to that in serum and with 0-12% disialotransferrin.	Iron	109-113	transferrin	Homo sapiens	114-125
18596229-2	2008	Here, we show that iron deficiency anemia with poor intestinal absorption and defective iron utilization of IV iron is caused by inherited mutations in TMPRSS6, a liver-expressed gene that encodes a membrane-bound serine protease of previously unknown role that was recently reported to be a regulator of hepcidin expression.	Iron	19-23	transmembrane serine protease 6	Homo sapiens	152-159
18596229-2	2008	Here, we show that iron deficiency anemia with poor intestinal absorption and defective iron utilization of IV iron is caused by inherited mutations in TMPRSS6, a liver-expressed gene that encodes a membrane-bound serine protease of previously unknown role that was recently reported to be a regulator of hepcidin expression.	Iron	88-92	transmembrane serine protease 6	Homo sapiens	152-159
18698850-8	2008	In fact, these agents were highly effective at mobilizing (59)Fe from prelabeled SK-N-MC cells and preventing (59)Fe uptake from the serum Fe transport protein, transferrin.	Iron	114-116	transferrin	Homo sapiens	161-172
18703380-5	2008	Many studies show a positive effect of Erythropoietin (EPO) or its" derivatives when administered in combination with oral or IV iron, with improvements in left and right ventricular systolic and diastolic function, dilation and hypertrophy and renal function.	Iron	129-133	erythropoietin	Homo sapiens	55-58
18466351-2	2008	Here we propose that iron directly influences the Abeta production through the modulation of furin, a proconvertase involved in the regulation of the alpha-secretase-dependent processing of the amyloid protein precursor (APP).	Iron	21-25	amyloid beta precursor protein	Homo sapiens	50-55
18466351-2	2008	Here we propose that iron directly influences the Abeta production through the modulation of furin, a proconvertase involved in the regulation of the alpha-secretase-dependent processing of the amyloid protein precursor (APP).	Iron	21-25	amyloid beta precursor protein	Homo sapiens	194-219
18550384-4	2008	WhiB3/Rv3416 has been shown to be important for pathogenesis in animal model and was recently shown to co-ordinate a Fe-S cluster.	Iron	117-121	redox-responsive transcriptional regulator WhiB3	Mycobacterium tuberculosis H37Rv	0-5
18586980-0	2008	The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome.	Iron	4-8	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	24-37
18586980-11	2008	The trafficking of FPN1 to the M. tuberculosis phagosome suggests that it is involved in regulating iron availability to the mycobacteria in this locale.	Iron	100-104	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	19-23
18758412-9	2008	CONCLUSIONS: In EPO resistant anemia, multiple factors, including iron and inflammation related conditions, are likely to affect the level of hepcidin and this may explain the lack of elevated serum hepcidin in this condition.	Iron	66-70	erythropoietin	Homo sapiens	16-19
18625724-1	2008	In a forward genetic screen for interaction with mitochondrial iron carrier proteins in Saccharomyces cerevisiae, a hypomorphic mutation of the essential DRE2 gene was found to confer lethality when combined with Delta mrs3 and Delta mrs4.	Iron	63-67	electron carrier DRE2	Saccharomyces cerevisiae S288C	154-158
18549825-2	2008	We previously found that lack of aldose reductase (AR), the first enzyme of the polyol pathway, attenuated the increase in transferrin (Tf) level in I/R brain, suggesting that AR contributes to iron-catalyzed free radical-induced damage.	Iron	194-198	transferrin	Rattus norvegicus	123-134
18549825-2	2008	We previously found that lack of aldose reductase (AR), the first enzyme of the polyol pathway, attenuated the increase in transferrin (Tf) level in I/R brain, suggesting that AR contributes to iron-catalyzed free radical-induced damage.	Iron	194-198	transferrin	Rattus norvegicus	136-138
18549825-7	2008	This activates HIF-1alpha that induces the expression of TfR, which in turn increases Tf uptake and iron accumulation and exacerbates oxidative damage that increases the lipid peroxidation.	Iron	100-104	transferrin	Rattus norvegicus	57-59
18550384-7	2008	The Fe-S cluster of WhiB3 remained bound in the presence of strong protein denaturant.	Iron	4-8	redox-responsive transcriptional regulator WhiB3	Mycobacterium tuberculosis H37Rv	20-25
18791966-11	2008	Serum ferritin and transferrin are useful parameters to screen for iron overload.	Iron	67-71	transferrin	Homo sapiens	19-30
18651766-11	2008	In PDF, the stronger interactions of iron with ligands allow iron-substrate coordination to take place either before or at a very early stage of the chemical step, leading to effective catalysis.	Iron	37-41	peptide deformylase	Escherichia coli	3-6
18705075-0	2008	On the "Inhibition of transferrin iron release increases in vitro drug carrier efficacy" (May 2, 2008).	Iron	34-38	transferrin	Homo sapiens	22-33
18574241-0	2008	Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	36-61
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	0-25
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	27-31
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	0-25
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	27-31
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	0-25
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	27-31
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	0-25
18574241-1	2008	Iron regulatory protein 2 (IRP2) is a key iron sensor that post-transcriptionally regulates mammalian iron homeostasis by binding to iron-responsive elements (IREs) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor 1).	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	27-31
18574241-2	2008	During iron deficiency, IRP2 binds IREs to regulate mRNA translation or stability, whereas during iron sufficiency IRP2 is degraded by the proteasome.	Iron	7-11	iron responsive element binding protein 2	Homo sapiens	24-28
18574241-3	2008	Here, we identify an iron-independent IRP2 phosphorylation site that is regulated by the cell cycle.	Iron	21-25	iron responsive element binding protein 2	Homo sapiens	38-42
18574241-6	2008	These data show that reversible phosphorylation of IRP2 during G(2)/M has a role in modulating the iron-independent expression of ferritin and other IRE-containing mRNAs during the cell cycle.	Iron	99-103	iron responsive element binding protein 2	Homo sapiens	51-55
18651766-11	2008	In PDF, the stronger interactions of iron with ligands allow iron-substrate coordination to take place either before or at a very early stage of the chemical step, leading to effective catalysis.	Iron	61-65	peptide deformylase	Escherichia coli	3-6
18697928-8	2008	A "metascreen" of previously collected ionomic data from 880 Arabidopsis mutants and natural accessions for this Fe response signature successfully identified the known Fe mutants frd1 and frd3.	Iron	113-115	MATE efflux family protein	Arabidopsis thaliana	189-193
18459142-5	2008	Besides, HIF-1alpha can be induced by iron chelators such as deferoxamine (DFO).	Iron	38-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
18541141-7	2008	In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.	Iron	137-141	interleukin 6	Rattus norvegicus	19-23
18541141-7	2008	In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.	Iron	137-141	hepcidin antimicrobial peptide	Rattus norvegicus	24-32
18720534-6	2008	RESULTS: According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities.	Iron	114-118	transferrin	Homo sapiens	22-33
18720534-6	2008	RESULTS: According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities.	Iron	132-136	transferrin	Homo sapiens	22-33
18720534-9	2008	CONCLUSION: In our patients, the presence of &gt;or2 alterations of the MS and hepatic steatosis was associated with a moderate form of iron overload with a prevalent sinusoidal distribution and a normal transferrin saturation, suggesting the existence of a peculiar pathogenetic mechanism of iron accumulation.	Iron	136-140	transferrin	Homo sapiens	204-215
18538129-4	2008	Upregulation of JMJD1A mRNA and protein in cultured human cells exposed to hypoxia or iron scavengers in vitro was abrogated when hypoxia-inducible factor-1 (HIF-1) signaling was blocked by siRNAs.	Iron	86-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-156
18538129-4	2008	Upregulation of JMJD1A mRNA and protein in cultured human cells exposed to hypoxia or iron scavengers in vitro was abrogated when hypoxia-inducible factor-1 (HIF-1) signaling was blocked by siRNAs.	Iron	86-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	158-163
18720534-11	2008	By contrast, patients with transferrin saturation&gt;or=60% had more severe iron overload, few or no metabolic abnormalities and a hemochromatosis-like pattern of iron overload.	Iron	76-80	transferrin	Homo sapiens	27-38
18720534-11	2008	By contrast, patients with transferrin saturation&gt;or=60% had more severe iron overload, few or no metabolic abnormalities and a hemochromatosis-like pattern of iron overload.	Iron	163-167	transferrin	Homo sapiens	27-38
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Iron	102-106	ATP binding cassette subfamily B member 1	Homo sapiens	182-185
18653817-4	2008	The clinic initiated iron therapy when a patient"s transferrin saturation (TSAT) was &lt;20% and serum ferritin concentration was &lt;100 ng/ mL, indicating low iron stores.	Iron	21-25	transferrin	Homo sapiens	51-62
18450970-1	2008	Hepcidin plays an essential role in maintaining normal iron homeostasis outside the brain.	Iron	55-59	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Iron	102-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-37
18385176-8	2008	Crocidolite, dexrazoxane and hypoxia induce doxorubicin resistance in human malignant mesothelioma cells by increasing hypoxia-inducible factor-1alpha activity, through an iron-sensitive mechanism.	Iron	172-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-150
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Iron	102-106	ATP binding cassette subfamily B member 1	Homo sapiens	166-180
18613854-2	2008	Concomitant intravenous (IV) iron supplementation has the potential to improve response to erythropoietin, allowing a decrease in erythropoietin dose requirements.	Iron	29-33	erythropoietin	Homo sapiens	91-105
18456389-0	2008	Nramp1 equips macrophages for efficient iron recycling.	Iron	40-44	solute carrier family 11 member 1	Homo sapiens	0-6
18456389-2	2008	As macrophages are responsible for the engulfment and clearance of senescent red blood cells (RBC), we hypothesize that Nramp1 may participate in the recycling of iron acquired through phagocytosis.	Iron	163-167	solute carrier family 11 member 1	Homo sapiens	120-126
18456389-5	2008	The pool of chelatable iron was also found to transiently increase following iron-loading with hemin or opsonized RBCs, with a greater increase observed in macrophages expressing Nramp1.	Iron	23-27	solute carrier family 11 member 1	Homo sapiens	179-185
18456389-6	2008	Overexpression of Nramp1 was also found to result in a greater cellular release of (59)Fe following phagocytosis of (59)Fe-labeled reticulocytes.	Iron	87-89	solute carrier family 11 member 1	Homo sapiens	18-24
18456389-6	2008	Overexpression of Nramp1 was also found to result in a greater cellular release of (59)Fe following phagocytosis of (59)Fe-labeled reticulocytes.	Iron	120-122	solute carrier family 11 member 1	Homo sapiens	18-24
18456389-9	2008	CONCLUSION: The rapid and strong induction of Nramp1 during erythrophagocytosis, combined with its positive effects on (59)Fe-release, HO-1 induction and phagocytic ability, suggest that Nramp1 has a role in the recycling of hemoglobin-derived iron by macrophages.	Iron	244-248	solute carrier family 11 member 1	Homo sapiens	46-52
18456389-9	2008	CONCLUSION: The rapid and strong induction of Nramp1 during erythrophagocytosis, combined with its positive effects on (59)Fe-release, HO-1 induction and phagocytic ability, suggest that Nramp1 has a role in the recycling of hemoglobin-derived iron by macrophages.	Iron	244-248	solute carrier family 11 member 1	Homo sapiens	187-193
18424449-4	2008	Lymphoblasts and fibroblasts of FA patients have evidence of cytosolic iron depletion, as indicated by increased levels of iron regulatory protein 2 (IRP2) and/or increased IRE-binding activity of IRP1.	Iron	71-75	iron responsive element binding protein 2	Homo sapiens	123-148
18424449-4	2008	Lymphoblasts and fibroblasts of FA patients have evidence of cytosolic iron depletion, as indicated by increased levels of iron regulatory protein 2 (IRP2) and/or increased IRE-binding activity of IRP1.	Iron	71-75	iron responsive element binding protein 2	Homo sapiens	150-154
18613854-8	2008	Thus, treatment with epoetin beta with IV iron resulted in overall cost savings of about 11% compared with epoetin beta without iron, mainly due to reduced erythropoietin dosages.	Iron	42-46	erythropoietin	Homo sapiens	21-28
18613854-8	2008	Thus, treatment with epoetin beta with IV iron resulted in overall cost savings of about 11% compared with epoetin beta without iron, mainly due to reduced erythropoietin dosages.	Iron	42-46	erythropoietin	Homo sapiens	156-170
18613854-8	2008	Thus, treatment with epoetin beta with IV iron resulted in overall cost savings of about 11% compared with epoetin beta without iron, mainly due to reduced erythropoietin dosages.	Iron	128-132	erythropoietin	Homo sapiens	21-28
18613854-10	2008	This suggests that epoetin beta with IV iron is a dominant therapy from a Swedish perspective.	Iron	40-44	erythropoietin	Homo sapiens	19-26
18613854-2	2008	Concomitant intravenous (IV) iron supplementation has the potential to improve response to erythropoietin, allowing a decrease in erythropoietin dose requirements.	Iron	29-33	erythropoietin	Homo sapiens	130-144
18613854-3	2008	In a recent study of anaemic, iron-replete patients with lymphoproliferative malignancies (Leukemia, 21, 2007, 627), the haemoglobin (Hb) increase and response rate were significantly greater in patients receiving epoetin beta with concomitant IV iron compared with patients receiving epoetin beta without IV iron (P &lt; 0.05).	Iron	30-34	erythropoietin	Homo sapiens	214-221
18613854-3	2008	In a recent study of anaemic, iron-replete patients with lymphoproliferative malignancies (Leukemia, 21, 2007, 627), the haemoglobin (Hb) increase and response rate were significantly greater in patients receiving epoetin beta with concomitant IV iron compared with patients receiving epoetin beta without IV iron (P &lt; 0.05).	Iron	30-34	erythropoietin	Homo sapiens	285-292
18613854-3	2008	In a recent study of anaemic, iron-replete patients with lymphoproliferative malignancies (Leukemia, 21, 2007, 627), the haemoglobin (Hb) increase and response rate were significantly greater in patients receiving epoetin beta with concomitant IV iron compared with patients receiving epoetin beta without IV iron (P &lt; 0.05).	Iron	247-251	erythropoietin	Homo sapiens	214-221
18613854-3	2008	In a recent study of anaemic, iron-replete patients with lymphoproliferative malignancies (Leukemia, 21, 2007, 627), the haemoglobin (Hb) increase and response rate were significantly greater in patients receiving epoetin beta with concomitant IV iron compared with patients receiving epoetin beta without IV iron (P &lt; 0.05).	Iron	247-251	erythropoietin	Homo sapiens	214-221
18613854-6	2008	RESULTS AND DISCUSSION: There was an improved response to epoetin beta with IV iron therapy and an almost 2-fold greater increase in Hb levels.	Iron	79-83	erythropoietin	Homo sapiens	58-65
18572962-4	2008	Among them, a ubiquitous and highly conserved iron-binding protein, Ferritin, was further characterized as a modulator for the expression of a TLR2-specific cytokine IL-10 in murine macrophage cells by using small-interfering RNA (siRNA).	Iron	46-50	interleukin 10	Mus musculus	166-171
18641331-12	2008	Our data suggest that hemopexin, by controlling heme-iron availability in lymphocytes, modulates responsiveness to IFN-gamma and, hence, autoimmune responses.	Iron	53-57	interferon gamma	Mus musculus	115-124
18598056-2	2008	Currently, there is a long-standing dispute regarding the role of Abeta-metal ion (Zn, Cu, and Fe) complexes in AD pathogenesis.	Iron	95-97	amyloid beta precursor protein	Homo sapiens	66-71
18559422-7	2008	We use the model to demonstrate effects on HIF1alpha expression from combined doses of five potential therapeutically targeted compounds (iron, ascorbate, hydrogen peroxide, 2-oxoglutarate, and succinate) influenced by cellular oxidation-reduction and involved in HIF1alpha hydroxylation.	Iron	138-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-52
18414140-0	2008	Novel red cell indices indicating reduced availability of iron are associated with high erythropoietin concentration and low ph level in the venous cord blood of newborns.	Iron	58-62	erythropoietin	Homo sapiens	88-102
18606475-3	2008	Recently, the spectrum of diseases attributable to abnormal Fe-S cluster biogenesis has extended beyond Friedreich ataxia to include a sideroblastic anemia with deficiency of glutaredoxin 5 and a myopathy associated with a deficiency of a Fe-S cluster assembly scaffold protein, ISCU.	Iron	60-64	iron-sulfur cluster assembly enzyme	Homo sapiens	279-283
18606475-3	2008	Recently, the spectrum of diseases attributable to abnormal Fe-S cluster biogenesis has extended beyond Friedreich ataxia to include a sideroblastic anemia with deficiency of glutaredoxin 5 and a myopathy associated with a deficiency of a Fe-S cluster assembly scaffold protein, ISCU.	Iron	239-243	iron-sulfur cluster assembly enzyme	Homo sapiens	279-283
18572272-10	2008	The hydrogeochemistry and widespread As enrichment in groundwater of Chia-Nan plain result from multiple processes, e.g., de-watering of deep crustal fluids, seawater intrusion, and biogeochemical cycling of Fe, As, and S in alluvial sediments.	Iron	208-210	chitinase acidic	Homo sapiens	69-73
18030498-7	2008	Thus, it would be prudent if iron were to continue to be used judiciously in patients who require erythropoietin.	Iron	29-33	erythropoietin	Homo sapiens	98-112
18579154-14	2008	This can explain why other metal-loaded transferrins or a protein such as HFE-with a lower affinity for R1 than iron-saturated transferrin but with, however, similar or higher affinities for the helical domain than the C-lobe-competes with iron-saturated transferrin in an unknown state towards interaction with R1.	Iron	112-116	transferrin	Homo sapiens	40-51
18579154-1	2008	During iron acquisition by the cell, complete homodimeric transferrin receptor 1 in an unknown state (R1) binds iron-loaded human serum apotransferrin in an unknown state (T) and allows its internalization in the cytoplasm.	Iron	7-11	transferrin	Homo sapiens	58-69
18519569-3	2008	However, enhanced iron acquisition by macrophages cannot be accounted for by the previously reported transferrin receptor (TfR1) down-regulation in macrophages exposed to lipopolysaccharide (LPS)/interferon gamma (IFNgamma) because it impairs a major iron uptake mechanism.	Iron	18-22	toll-like receptor 4	Mus musculus	191-194
18519569-3	2008	However, enhanced iron acquisition by macrophages cannot be accounted for by the previously reported transferrin receptor (TfR1) down-regulation in macrophages exposed to lipopolysaccharide (LPS)/interferon gamma (IFNgamma) because it impairs a major iron uptake mechanism.	Iron	18-22	interferon gamma	Mus musculus	196-212
18579154-14	2008	This can explain why other metal-loaded transferrins or a protein such as HFE-with a lower affinity for R1 than iron-saturated transferrin but with, however, similar or higher affinities for the helical domain than the C-lobe-competes with iron-saturated transferrin in an unknown state towards interaction with R1.	Iron	112-116	transferrin	Homo sapiens	127-138
18519569-5	2008	Exposure of mouse macrophages (RAW 264.7 and J774A.1 cells or peritoneal macrophages) to LPS/IFNgamma up-regulated NF-kappaB, which in turn rapidly and transiently activated HIF-1-dependent TfR1 expression and iron uptake.	Iron	210-214	toll-like receptor 4	Mus musculus	89-92
18519569-5	2008	Exposure of mouse macrophages (RAW 264.7 and J774A.1 cells or peritoneal macrophages) to LPS/IFNgamma up-regulated NF-kappaB, which in turn rapidly and transiently activated HIF-1-dependent TfR1 expression and iron uptake.	Iron	210-214	interferon gamma	Mus musculus	93-101
18579154-1	2008	During iron acquisition by the cell, complete homodimeric transferrin receptor 1 in an unknown state (R1) binds iron-loaded human serum apotransferrin in an unknown state (T) and allows its internalization in the cytoplasm.	Iron	112-116	transferrin	Homo sapiens	58-69
18519569-5	2008	Exposure of mouse macrophages (RAW 264.7 and J774A.1 cells or peritoneal macrophages) to LPS/IFNgamma up-regulated NF-kappaB, which in turn rapidly and transiently activated HIF-1-dependent TfR1 expression and iron uptake.	Iron	210-214	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
18579154-14	2008	This can explain why other metal-loaded transferrins or a protein such as HFE-with a lower affinity for R1 than iron-saturated transferrin but with, however, similar or higher affinities for the helical domain than the C-lobe-competes with iron-saturated transferrin in an unknown state towards interaction with R1.	Iron	240-244	transferrin	Homo sapiens	40-51
18579154-14	2008	This can explain why other metal-loaded transferrins or a protein such as HFE-with a lower affinity for R1 than iron-saturated transferrin but with, however, similar or higher affinities for the helical domain than the C-lobe-competes with iron-saturated transferrin in an unknown state towards interaction with R1.	Iron	240-244	transferrin	Homo sapiens	127-138
18541424-4	2008	The N-hydroxypyridin-2(1H)one moiety provides a novel pharmacophore for the design of cyclic hydroxamic mimetics capable of chelating 5-LOX iron for exploitation in the design of 5-LOX inhibitory AI drugs.	Iron	140-144	arachidonate 5-lipoxygenase	Homo sapiens	134-139
18563879-0	2008	Mechanism of single metal exchange in the reactions of [M4(SPh)10]2- (M = Zn or Fe) with CoX2 (X = Cl or NO3) or FeCl2.	Iron	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
18468515-2	2008	We evaluated the superoxide (O2*-) scavenging activities of PFD and the PFD-iron complex by electron spin resonance (ESR) spectroscopy, luminol-dependent chemiluminescence assay, and cytochrome c reduction assay.	Iron	76-80	cytochrome c, somatic	Homo sapiens	183-195
18471984-9	2008	The ability to determine accurate epsilon values for transferrin mutants that bind iron with a wide range of affinities has proven to be very useful; furthermore, a similar approach could easily be followed to determine epsilon values for other metalloproteins in which metal binding contributes to the A(280).	Iron	83-87	transferrin	Homo sapiens	53-64
18627600-9	2008	In addition, we show that the drug resistance regulator gene YRR1 and the iron homeostasis regulator gene AFT2 are both directly regulated by Yap1p.	Iron	74-78	Aft2p	Saccharomyces cerevisiae S288C	106-110
18627600-9	2008	In addition, we show that the drug resistance regulator gene YRR1 and the iron homeostasis regulator gene AFT2 are both directly regulated by Yap1p.	Iron	74-78	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	142-147
18635001-0	2008	The small-molecule iron transport inhibitor ferristatin/NSC306711 promotes degradation of the transferrin receptor.	Iron	19-23	transferrin	Homo sapiens	94-105
18635001-1	2008	Iron delivery by transferrin (Tf) is accomplished through clathrin-mediated endocytosis of Tf receptors.	Iron	0-4	transferrin	Homo sapiens	17-28
18541424-4	2008	The N-hydroxypyridin-2(1H)one moiety provides a novel pharmacophore for the design of cyclic hydroxamic mimetics capable of chelating 5-LOX iron for exploitation in the design of 5-LOX inhibitory AI drugs.	Iron	140-144	arachidonate 5-lipoxygenase	Homo sapiens	179-184
18597674-3	2008	One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake.	Iron	17-21	transferrin	Homo sapiens	44-55
18621680-0	2008	The MCK mouse heart model of Friedreich"s ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation.	Iron	65-69	creatine kinase, muscle	Mus musculus	4-7
18621680-0	2008	The MCK mouse heart model of Friedreich"s ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation.	Iron	128-132	creatine kinase, muscle	Mus musculus	4-7
18597674-3	2008	One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake.	Iron	101-105	transferrin	Homo sapiens	44-55
18597674-9	2008	CONCLUSION: These observations suggest that in the case of abnormal pregnancies, the fetus may require higher levels of transferrin in order to prevent iron depletion due to the stress from the placental dysfunction.	Iron	152-156	transferrin	Homo sapiens	120-131
18439415-5	2008	Experiments replacing the Fe of cytochrome c with redox-inactive metals indicate that cytochrome c does not have to change redox states to activate caspases.	Iron	26-28	cytochrome c, somatic	Homo sapiens	32-44
18324632-0	2008	Iron Age breastfeeding practices in Britain: isotopic evidence from Wetwang Slack, East Yorkshire.	Iron	0-4	potassium sodium-activated channel subfamily T member 1	Homo sapiens	76-81
18366107-4	2008	Results revealed that both ferritin and percent transferrin saturation levels had strong positive correlations with hepatic iron concentration (P&lt;0.001, r=0.77, n=20; P&lt;0.001, r=0.85, n=10, respectively).	Iron	124-128	transferrin	Homo sapiens	48-59
18439415-5	2008	Experiments replacing the Fe of cytochrome c with redox-inactive metals indicate that cytochrome c does not have to change redox states to activate caspases.	Iron	26-28	cytochrome c, somatic	Homo sapiens	86-98
18430192-8	2008	Traditional markers of iron availability, such as serum ferritin and transferrin saturation display interpretation pitfalls.	Iron	23-27	transferrin	Homo sapiens	69-80
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	24-28	transferrin	Homo sapiens	39-50
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	201-205	transferrin	Homo sapiens	183-194
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	201-205	transferrin	Homo sapiens	183-194
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	201-205	transferrin	Homo sapiens	183-194
18430498-4	2008	Non-transferrin bound iron plays an important role in cellular iron excess and damage.	Iron	22-26	transferrin	Homo sapiens	4-15
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	201-205	transferrin	Homo sapiens	183-194
18430498-4	2008	Non-transferrin bound iron plays an important role in cellular iron excess and damage.	Iron	63-67	transferrin	Homo sapiens	4-15
18423402-7	2008	PON1"s arylesterase activity reflected anemia severity, being correlated with hemoglobin, hematocrit, and iron.	Iron	106-110	paraoxonase 1	Homo sapiens	0-4
18426863-0	2008	Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload.	Iron	96-100	insulin	Homo sapiens	66-73
18546145-5	2008	Here we discuss how activation of macrophages with IFN-gamma not only up-regulates antimicrobial effector mechanisms but also modulates iron regulatory proteins such as ferroportin to reduce intracellular iron availability.	Iron	136-140	interferon gamma	Homo sapiens	51-60
18546145-5	2008	Here we discuss how activation of macrophages with IFN-gamma not only up-regulates antimicrobial effector mechanisms but also modulates iron regulatory proteins such as ferroportin to reduce intracellular iron availability.	Iron	205-209	interferon gamma	Homo sapiens	51-60
18923665-1	2008	BACKGROUND AND AIM: Iron overload and inflammation might participate in the pathogenesis of insulin resistance in community.	Iron	20-24	insulin	Homo sapiens	92-99
18923665-12	2008	CONCLUSIONS: The present study demonstrated that Epo treatment could participate in reducing insulin resistance through iron stores reduction and improvement of chronic inflammation in patients on maintenance HD.	Iron	120-124	erythropoietin	Homo sapiens	49-52
18923665-12	2008	CONCLUSIONS: The present study demonstrated that Epo treatment could participate in reducing insulin resistance through iron stores reduction and improvement of chronic inflammation in patients on maintenance HD.	Iron	120-124	insulin	Homo sapiens	93-100
18326661-3	2008	To date, ferritin has been overexpressed in vivo and has been coexpressed with transferrin receptor to increase iron loading in cells.	Iron	112-116	transferrin	Homo sapiens	79-90
18581323-2	2008	As the activity of IFN-gamma is modulated by iron and since a sufficient availability of iron is essential for the growth of pathogens, we investigated the regulatory effects of IFN-gamma on iron homeostasis and immune function in murine macrophages infected with Salmonella typhimurium.	Iron	45-49	interferon gamma	Mus musculus	19-28
18581323-3	2008	In Salmonella-infected phagocytes, IFN-gamma caused a significant reduction of iron uptake via transferrin receptor 1 and resulted in an increased iron efflux caused by an enhanced expression of the iron exporter ferroportin 1.	Iron	79-83	interferon gamma	Mus musculus	35-44
18581323-3	2008	In Salmonella-infected phagocytes, IFN-gamma caused a significant reduction of iron uptake via transferrin receptor 1 and resulted in an increased iron efflux caused by an enhanced expression of the iron exporter ferroportin 1.	Iron	147-151	interferon gamma	Mus musculus	35-44
18581323-3	2008	In Salmonella-infected phagocytes, IFN-gamma caused a significant reduction of iron uptake via transferrin receptor 1 and resulted in an increased iron efflux caused by an enhanced expression of the iron exporter ferroportin 1.	Iron	147-151	interferon gamma	Mus musculus	35-44
18581323-5	2008	This observed regulatory impact of IFN-gamma reduced the intracellular iron pools within infected phagocytes, thus restricting the acquisition of iron by engulfed Salmonella typhimurium while concomitantly promoting NO and TNF-alpha production.	Iron	71-75	interferon gamma	Mus musculus	35-44
18581323-5	2008	This observed regulatory impact of IFN-gamma reduced the intracellular iron pools within infected phagocytes, thus restricting the acquisition of iron by engulfed Salmonella typhimurium while concomitantly promoting NO and TNF-alpha production.	Iron	146-150	interferon gamma	Mus musculus	35-44
18581323-6	2008	Our data suggest that the modulation of crucial pathways of macrophage iron metabolism in response to IFN-gamma concordantly aims at withdrawing iron from intracellular Salmonella and at strengthening macrophage immune response functions.	Iron	71-75	interferon gamma	Mus musculus	102-111
18581323-6	2008	Our data suggest that the modulation of crucial pathways of macrophage iron metabolism in response to IFN-gamma concordantly aims at withdrawing iron from intracellular Salmonella and at strengthening macrophage immune response functions.	Iron	145-149	interferon gamma	Mus musculus	102-111
18638094-7	2008	A strong correlation was found between iron indices and oxidative stress (MDA and ferritin r=0.95; p&lt;0.001; MDA and transferrin saturation r=0.80, p&lt;0.01).	Iron	39-43	transferrin	Homo sapiens	119-130
18426863-3	2008	We hypothesized that iron-associated insulin resistance could be behind the impaired insulin action caused by RBP4.	Iron	21-25	insulin	Homo sapiens	37-44
18594779-4	2008	The free irons, non-transferrin-bound iron, and labile plasma iron in the circulation, and the labile iron pool within the cells, are responsible for iron toxicity.	Iron	38-42	transferrin	Homo sapiens	20-31
18599958-1	2008	When maintained on a folate-deficient, iron-rich diet, transgenic mice lacking in apolipoprotein E (ApoE-/- mice) demonstrate impaired activity of glutathione S-transferase (GST), resulting in increased oxidative species within brain tissue despite abnormally high levels of glutathione.	Iron	39-43	apolipoprotein E	Mus musculus	82-98
18594779-4	2008	The free irons, non-transferrin-bound iron, and labile plasma iron in the circulation, and the labile iron pool within the cells, are responsible for iron toxicity.	Iron	38-42	transferrin	Homo sapiens	20-31
18462824-9	2008	The relatively elevated urinary hepcidin can explain the iron phenotype in DHIO (more macrophage iron retention and low/normal transferrin saturation).	Iron	57-61	transferrin	Homo sapiens	127-138
18673149-1	2008	Plasma non-transferrin bound iron (NTBI) is potentially toxic and contributes to the generation of reactive oxygen species (ROS), consequently leading to tissue damage and organ dysfunction.	Iron	29-33	transferrin	Rattus norvegicus	11-22
18839536-0	2008	[Effect of higher iron in diet on iron levels and hepcidin mRNA expression levels in rats].	Iron	18-22	hepcidin antimicrobial peptide	Rattus norvegicus	50-58
18309490-9	2008	IL-6 levels showed positive correlation with CRP, and negative correlation with Hb, RBC counts and serum iron, but TNFalpha did not show any correlation.	Iron	105-109	interleukin 6	Homo sapiens	0-4
18439665-3	2008	Further, DA-induced oxidative induction was potentiated (P&lt;0.001) in the presence of iron (5 microM) and 3-amino triazole and mercaptosuccinate (P&lt;0.001), known inhibitors of the peroxide metabolizing enzymes, catalase and glutathione peroxidase, respectively.	Iron	88-92	catalase	Rattus norvegicus	216-224
18839536-1	2008	OBJECTIVE: To study the effects of higher iron in diet on weight, iron status and hepcidin mRNA expression level in rats.	Iron	42-46	hepcidin antimicrobial peptide	Rattus norvegicus	82-90
18839536-8	2008	With the increases of iron levels in diet, the levels of serum iron, serum ferretin, and transferrin saturation were gradually increased, and the hepcidin mRNA expression level in liver significantly increased, and the expression of ferroprotin mRNA expression level in duodenum was decreased.	Iron	22-26	transferrin	Rattus norvegicus	89-100
18839536-8	2008	With the increases of iron levels in diet, the levels of serum iron, serum ferretin, and transferrin saturation were gradually increased, and the hepcidin mRNA expression level in liver significantly increased, and the expression of ferroprotin mRNA expression level in duodenum was decreased.	Iron	22-26	hepcidin antimicrobial peptide	Rattus norvegicus	146-154
18839536-9	2008	CONCLUSION: Higher iron diet could influence the weights, serum iron status, liver hepcidin and duodenum ferroportin mRNA expression levels of the rats.	Iron	19-23	hepcidin antimicrobial peptide	Rattus norvegicus	83-91
18395385-6	2008	Simultaneously, the mRNA abundance of transferrin receptor-1 decreased by 80% with age and 48% with HS for young animals, while that of the hepcidin regulator hemojuvelin decreased 37% with age, but increased about 44% with disuse, indicating a dysregulation of iron homeostasis favoring increased intracellular free iron in atrophied muscles.	Iron	262-266	hepcidin antimicrobial peptide	Rattus norvegicus	140-148
18503586-8	2008	Adding holo-transferrin to iron-depleted cultures elevated LIP by 3.9-fold.	Iron	27-31	transferrin	Homo sapiens	12-23
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	Iron	129-131	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18625454-3	2008	Copper (and iron) can also promote the neurotoxic redox activity of Abeta and induce oxidative cross-linking of the peptide into stable oligomers.	Iron	12-16	amyloid beta precursor protein	Homo sapiens	68-73
18515233-4	2008	Besides transferrin iron release, mobilization of ferritin iron is also possible.	Iron	20-24	transferrin	Rattus norvegicus	8-19
18598585-11	2008	In the absence of inflammation, a sensitive method to assess iron status is to combine the use of serum ferritin as a measure of iron stores and the serum transferrin receptor as a measure of tissue iron deficiency.	Iron	61-65	transferrin	Homo sapiens	155-166
18395385-6	2008	Simultaneously, the mRNA abundance of transferrin receptor-1 decreased by 80% with age and 48% with HS for young animals, while that of the hepcidin regulator hemojuvelin decreased 37% with age, but increased about 44% with disuse, indicating a dysregulation of iron homeostasis favoring increased intracellular free iron in atrophied muscles.	Iron	317-321	hepcidin antimicrobial peptide	Rattus norvegicus	140-148
18296749-4	2008	The 1.6-Mb disease-critical region contained one obvious candidate gene-ISCU-specifying a protein involved in iron-sulphur cluster assembly.	Iron	110-114	iron-sulfur cluster assembly enzyme	Homo sapiens	72-76
18505395-5	2008	The transferrin-iron transport system is not subject to high-frequency phase or antigenic variation and is expressed by all pathogenic Neisseria.	Iron	16-20	transferrin	Homo sapiens	4-15
18408021-2	2008	The significance of iron for brain function is reflected by the presence of receptors for transferrin on brain capillary endothelial cells.	Iron	20-24	transferrin	Homo sapiens	90-101
18413491-6	2008	While standardizing to mean sodium excretion (8.7 mmol/h) and adjusting for covariates and relatedness, RNa(dist) was lower in DRD1 -94GG homozygotes than -94A allele carriers (effect size, -0.94%; P=0.005) with opposite findings for FE(Na) (+0.084%; P=0.014).	Iron	234-236	dopamine receptor D1	Homo sapiens	127-131
19669305-7	2008	FRAP was lower in ALD as compared with NAFLD (345.4 (56-615.9) vs. 434.1 (197.6-733.3) mumol of Fe(+2) liberated; P = 0.001) but similar to that of controls (340.9 (141.5-697.5) mumol of Fe(+2) liberated).	Iron	96-98	mechanistic target of rapamycin kinase	Homo sapiens	0-4
19669305-7	2008	FRAP was lower in ALD as compared with NAFLD (345.4 (56-615.9) vs. 434.1 (197.6-733.3) mumol of Fe(+2) liberated; P = 0.001) but similar to that of controls (340.9 (141.5-697.5) mumol of Fe(+2) liberated).	Iron	187-189	mechanistic target of rapamycin kinase	Homo sapiens	0-4
18408021-6	2008	The increased serum level of soluble transferrin receptor (sTfR) may indicate an abnormal intracellular distribution of iron and a decrease in the cytoplasmic compartment.	Iron	120-124	transferrin	Homo sapiens	37-48
18330662-6	2008	RESULTS: A high prevalence of iron depletion was present in this cohort, with 53% having a transferrin saturation ratio below 0.20.	Iron	30-34	transferrin	Homo sapiens	91-102
18330662-7	2008	Iron depletion was significantly correlated with raised levels of indices of inflammation, C-reactive protein (CRP), orosomucoid and haptoglobin), and with the white blood cell count.	Iron	0-4	C-reactive protein	Homo sapiens	91-109
18330662-7	2008	Iron depletion was significantly correlated with raised levels of indices of inflammation, C-reactive protein (CRP), orosomucoid and haptoglobin), and with the white blood cell count.	Iron	0-4	haptoglobin	Homo sapiens	133-144
18330662-8	2008	In multivariate analysis, orosomucoid and CRP were independently associated with iron depletion.	Iron	81-85	C-reactive protein	Homo sapiens	42-45
18330662-7	2008	Iron depletion was significantly correlated with raised levels of indices of inflammation, C-reactive protein (CRP), orosomucoid and haptoglobin), and with the white blood cell count.	Iron	0-4	C-reactive protein	Homo sapiens	111-114
18702344-8	2008	Body iron stores affect the indicators of liver function, such as GGT AST and ALT and the concentration of alcohol abuse marker such as carbohydrate-deficient transferrin (CDT) in the serum.	Iron	5-9	solute carrier family 17 member 5	Homo sapiens	70-73
17936676-0	2008	Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous carcinoma cells.	Iron	0-4	mitogen-activated protein kinase 1	Homo sapiens	63-66
17936676-0	2008	Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous carcinoma cells.	Iron	0-4	AKT serine/threonine kinase 1	Homo sapiens	67-70
17936676-7	2008	Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt.	Iron	120-124	mitogen-activated protein kinase 3	Homo sapiens	76-82
17936676-7	2008	Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt.	Iron	120-124	AKT serine/threonine kinase 1	Homo sapiens	91-94
17936676-7	2008	Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt.	Iron	120-124	mitogen-activated protein kinase 3	Homo sapiens	149-155
17936676-7	2008	Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt.	Iron	120-124	AKT serine/threonine kinase 1	Homo sapiens	160-163
17936676-7	2008	Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt.	Iron	120-124	mitogen-activated protein kinase 3	Homo sapiens	149-155
17936676-7	2008	Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt.	Iron	120-124	AKT serine/threonine kinase 1	Homo sapiens	160-163
18702344-8	2008	Body iron stores affect the indicators of liver function, such as GGT AST and ALT and the concentration of alcohol abuse marker such as carbohydrate-deficient transferrin (CDT) in the serum.	Iron	5-9	transferrin	Homo sapiens	159-170
18511687-4	2008	Human poly (rC)-binding protein 1 (PCBP1) increased the amount of iron loaded into ferritin when expressed in yeast.	Iron	66-70	poly(rC) binding protein 1	Homo sapiens	6-33
18282683-5	2008	In addition, inhibition of alpha 7 nAChR at protein level was observed in the cells exposed to high amounts of fluoride or ferrous iron.	Iron	123-135	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	35-40
18511687-4	2008	Human poly (rC)-binding protein 1 (PCBP1) increased the amount of iron loaded into ferritin when expressed in yeast.	Iron	66-70	poly(rC) binding protein 1	Homo sapiens	35-40
18511687-5	2008	PCBP1 bound to ferritin in vivo and bound iron and facilitated iron loading into ferritin in vitro.	Iron	42-46	poly(rC) binding protein 1	Homo sapiens	0-5
18430582-1	2008	Ovotransferrin is a main member of transferrin family and has a dual role in both the transport of iron and antibacterial function.	Iron	99-103	transferrin	Homo sapiens	3-14
18511687-5	2008	PCBP1 bound to ferritin in vivo and bound iron and facilitated iron loading into ferritin in vitro.	Iron	63-67	poly(rC) binding protein 1	Homo sapiens	0-5
18511687-6	2008	Depletion of PCBP1 in human cells inhibited ferritin iron loading and increased cytosolic iron pools.	Iron	53-57	poly(rC) binding protein 1	Homo sapiens	13-18
18511687-6	2008	Depletion of PCBP1 in human cells inhibited ferritin iron loading and increased cytosolic iron pools.	Iron	90-94	poly(rC) binding protein 1	Homo sapiens	13-18
18511687-7	2008	Thus, PCBP1 can function as a cytosolic iron chaperone in the delivery of iron to ferritin.	Iron	40-44	poly(rC) binding protein 1	Homo sapiens	6-11
18511687-7	2008	Thus, PCBP1 can function as a cytosolic iron chaperone in the delivery of iron to ferritin.	Iron	74-78	poly(rC) binding protein 1	Homo sapiens	6-11
18189270-0	2008	Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats.	Iron	83-87	solute carrier family 40 member 1	Rattus norvegicus	29-42
18495927-2	2008	Thus, erythroid precursor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds to the transferrin receptor (TfR) at the cell surface.	Iron	67-71	transferrin	Homo sapiens	100-111
18495927-2	2008	Thus, erythroid precursor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds to the transferrin receptor (TfR) at the cell surface.	Iron	88-92	transferrin	Homo sapiens	100-111
18495927-4	2008	Upon endosomal acidification, iron is released from Tf, reduced to Fe(2+) by Steap3, and transported across the endosomal membrane by divalent metal iron transporter 1.	Iron	30-34	STEAP3 metalloreductase	Homo sapiens	77-83
18509548-17	2008	Similarly, exogenous human apo-Tf, but not human holo-Tf, conferred resistance to iron-induced stress on MG cells from WT mice.	Iron	82-86	transferrin	Homo sapiens	31-33
18549630-5	2008	It is concluded that IRP(2) protein serves as an important regulator of iron metabolism in the human body, and regulates iron uptake from the intestine by controlling the expression of fn mRNA at the post transcriptional level.	Iron	72-76	iron responsive element binding protein 2	Homo sapiens	21-26
18549630-5	2008	It is concluded that IRP(2) protein serves as an important regulator of iron metabolism in the human body, and regulates iron uptake from the intestine by controlling the expression of fn mRNA at the post transcriptional level.	Iron	121-125	iron responsive element binding protein 2	Homo sapiens	21-26
18189270-11	2008	We conclude that hepcidin may play a major, causative role in the change of FPN1 synthesis and that decreased the iron retention in macrophages of rHuEpo-treated rats.	Iron	114-118	hepcidin antimicrobial peptide	Rattus norvegicus	17-25
18493046-0	2008	FER1 and FER2 encoding two ferritin complexes in Chlamydomonas reinhardtii chloroplasts are regulated by iron.	Iron	105-109	uncharacterized protein	Chlamydomonas reinhardtii	0-4
18359301-5	2008	They resemble ferrous LPO, being five-coordinated high-spin species that are distinguished by the strength of the proximal Fe-histidine bond.	Iron	123-125	lactoperoxidase	Homo sapiens	22-25
18371939-2	2008	Deferoxamine (DFX), an iron chelator stabilizes the HIF-1alpha and activates target genes involved in compensation for ischemia.	Iron	23-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
18296681-1	2008	Iron overload may increase prostate cancer risk through stimulation of oxidative stress, and endogenous pro- and antioxidant capabilities, i.e. manganese superoxide dismutase (MnSOD) and myeloperoxidase (MPO), may modify these associations.	Iron	0-4	myeloperoxidase	Homo sapiens	187-202
18296681-1	2008	Iron overload may increase prostate cancer risk through stimulation of oxidative stress, and endogenous pro- and antioxidant capabilities, i.e. manganese superoxide dismutase (MnSOD) and myeloperoxidase (MPO), may modify these associations.	Iron	0-4	myeloperoxidase	Homo sapiens	204-207
18296681-5	2008	Associations between MPO -463 G to A genotype (rs2333227) and prostate cancer risk were only noted among men with aggressive cancer, with more than a 2-fold risk reduction among men with AA genotypes (OR = 0.4, 95% CI = 0.2-1.0); MnSOD was not associated with risk overall, but the MnSOD T to C (Val-9Ala, rs4880) polymorphism modified associations between risk of clinically aggressive prostate cancer and dietary iron intake (P for interaction = 0.02).	Iron	415-419	myeloperoxidase	Homo sapiens	21-24
18048580-2	2008	Also, there is a direct link between iron metabolism and AD pathogenesis, demonstrated by the presence of an iron-responsive element in the 5" UTR of the amyloid precursor protein transcript.	Iron	37-41	amyloid beta precursor protein	Homo sapiens	154-179
18048580-2	2008	Also, there is a direct link between iron metabolism and AD pathogenesis, demonstrated by the presence of an iron-responsive element in the 5" UTR of the amyloid precursor protein transcript.	Iron	109-113	amyloid beta precursor protein	Homo sapiens	154-179
18532815-3	2008	The results show that it is favorable for the Fe atom to locate at the surface, not at the center of the cluster, and that FeB(4) and FeB(9) clusters exhibit high stability.	Iron	46-48	FEB9	Homo sapiens	134-140
18347019-0	2008	Non-transferrin iron reduction and uptake are regulated by transmembrane ascorbate cycling in K562 cells.	Iron	16-20	transferrin	Homo sapiens	4-15
18347019-1	2008	K562 erythroleukemia cells import non-transferrin-bound iron (NTBI) by an incompletely understood process that requires initial iron reduction.	Iron	56-60	transferrin	Homo sapiens	38-49
18347019-1	2008	K562 erythroleukemia cells import non-transferrin-bound iron (NTBI) by an incompletely understood process that requires initial iron reduction.	Iron	128-132	transferrin	Homo sapiens	38-49
18481019-5	2008	The pre-treatment of rats with FE, however, suppressed the increment of levels of GOT, GPT, ALP, LDH and MDA, as well as recovered the levels of SOD, CAT and GPx in CCl(4)-treated rats.	Iron	31-33	catalase	Rattus norvegicus	150-153
18493046-3	2008	Both FER1 and FER2 transcripts are increased in abundance as iron nutrition is decreased but the pattern for each gene is distinct.	Iron	61-65	uncharacterized protein	Chlamydomonas reinhardtii	5-9
18493046-5	2008	In response to low iron, ferritin1 subunits and the ferritin1 complex are increased in parallel to the increase in FER1 mRNA.	Iron	19-23	uncharacterized protein	Chlamydomonas reinhardtii	115-119
18248518-1	2008	Intravenous iron treatment in hemodialysis patients improves response to recombinant human erythropoietin and facilitates achievement of targets for hemoglobin and hematocrit.	Iron	12-16	erythropoietin	Homo sapiens	91-105
19238778-4	2008	Factors modulating iron-related organ damage include alcohol consumption, the metabolic syndrome, and the TGF-beta1 (hepatic fibrosis) and superoxide dismutase genes (cardiomyopathy).	Iron	19-23	transforming growth factor beta 1	Homo sapiens	106-115
18525129-2	2008	In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998.	Iron	99-103	apolipoprotein E	Homo sapiens	44-60
18525129-2	2008	In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998.	Iron	99-103	apolipoprotein E	Homo sapiens	62-66
18408718-2	2008	Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin.	Iron	19-23	transmembrane serine protease 6	Homo sapiens	113-120
18408718-2	2008	Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin.	Iron	61-65	transmembrane serine protease 6	Homo sapiens	113-120
18408718-3	2008	These findings demonstrate that TMPRSS6 is essential for normal systemic iron homeostasis in humans.	Iron	73-77	transmembrane serine protease 6	Homo sapiens	32-39
17987045-12	2008	Intracerebral infusion of iron also resulted in enhanced conversion of LC3-I to LC3-II and increased cathepsin D levels.	Iron	26-30	cathepsin D	Rattus norvegicus	101-112
17987045-13	2008	Deferoxamine (an iron chelator) treatment significantly reduced the conversion of LC3-I to LC3-II and cathepsin D levels after ICH.	Iron	17-21	cathepsin D	Rattus norvegicus	102-113
18434354-0	2008	Pancreatic beta-cells express hepcidin, an iron-uptake regulatory peptide.	Iron	43-47	hepcidin antimicrobial peptide	Rattus norvegicus	30-38
18434354-6	2008	As demonstrated in insulinoma-derived RINm5F cells, the expression of hepcidin in beta-cells is regulated by iron.	Iron	109-113	hepcidin antimicrobial peptide	Rattus norvegicus	70-78
18397204-3	2008	One mechanism thought to mediate iron deficiency-induced thrombocytosis is increased erythropoietin production.	Iron	33-37	erythropoietin	Homo sapiens	85-99
18281282-8	2008	The Fra1-Fra2 complex binds to Grx3 and Grx4, two cytosolic monothiol glutaredoxins, in an iron-independent fashion.	Iron	91-95	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	40-44
18430216-1	2008	BACKGROUND: Transferrin binding protein B (tbpB), an outer membrane lipoprotein, is required for the acquisition of iron from human transferrin.	Iron	116-120	transferrin	Homo sapiens	12-23
18430216-1	2008	BACKGROUND: Transferrin binding protein B (tbpB), an outer membrane lipoprotein, is required for the acquisition of iron from human transferrin.	Iron	116-120	transferrin	Homo sapiens	132-143
18022819-11	2008	We suggest alternative models for loading Tf with Fe(III) during intestinal iron export.	Iron	76-80	transferrin	Homo sapiens	42-44
18364240-4	2008	We report for the first time that bicarbonate is required as a synergistic anion for stable ferrous binding to MtsA, similar to the iron binding in human transferrin.	Iron	132-136	transferrin	Homo sapiens	154-165
17973296-0	2008	Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.	Iron	113-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-79
17973296-9	2008	The use of quercetin"s analogues showed that only quercetin and galangin induce HIF-1/2alpha accumulation and this effect is completely reversed by additional iron ions.	Iron	159-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
17973296-10	2008	This is because quercetin and galangin are able to chelate cellular iron ions that are cofactors of HIF-1/2alpha proline hydroxylase (PHD).	Iron	68-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-105
18398482-4	2008	XLSA/A is caused by partial inactivating mutations of the ABCB7 ATP-binding cassette transporter gene, which functions to enable transport of iron from the mitochondria to the cytoplasm.	Iron	142-146	ATP binding cassette subfamily A member 4	Homo sapiens	64-96
17973296-11	2008	These data suggest that quercetin inhibits the ubiquitination of HIF-1/2alpha in normoxia by hindering PHD through chelating iron ions.	Iron	125-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-70
18022819-7	2008	As such, it has been suggested that as a means of preventing the release of unbound Fe(III), a direct protein-protein interaction may occur between Tf and Hp during intestinal iron export.	Iron	176-180	transferrin	Homo sapiens	148-150
18354500-4	2008	These Grxs possess the same monothiol CGFS active site as yeast Grx5 and both were able to complement a yeast grx5 mutant defective in Fe-S cluster assembly.	Iron	135-139	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	64-68
18354500-4	2008	These Grxs possess the same monothiol CGFS active site as yeast Grx5 and both were able to complement a yeast grx5 mutant defective in Fe-S cluster assembly.	Iron	135-139	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	110-114
18206118-8	2008	Furthermore, NO-mediated Fe release is mediated from cells expressing the GSH transporter, multi-drug resistance protein 1 (MRP1).	Iron	25-27	ATP binding cassette subfamily C member 1	Homo sapiens	124-128
18072938-2	2008	Following haem catabolism by HO1 (haem oxygenase 1), they recycle iron back into the plasma through the iron exporter Fpn (ferroportin).	Iron	66-70	heme oxygenase 1	Mus musculus	29-32
18094362-6	2008	The presence of iron appeared essential for dimeric transferrin inhibitory activity.	Iron	16-20	transferrin	Homo sapiens	52-63
18061679-4	2008	It is hypothesized that Fe uptake is blocked by reactive oxygen species generated by FeT(2) or CuT that damage transferrin or transferrin receptor.	Iron	24-26	transferrin	Homo sapiens	111-122
18314014-6	2008	Both DNA repair proteins, containing Fe-S clusters, and the transcription factor, p53, which is regulated through thiol-disulfide switches, can be oxidized from a distance through DNA-mediated CT.	Iron	37-41	tumor protein p53	Homo sapiens	82-85
18072938-2	2008	Following haem catabolism by HO1 (haem oxygenase 1), they recycle iron back into the plasma through the iron exporter Fpn (ferroportin).	Iron	66-70	heme oxygenase 1	Mus musculus	34-50
18072938-2	2008	Following haem catabolism by HO1 (haem oxygenase 1), they recycle iron back into the plasma through the iron exporter Fpn (ferroportin).	Iron	104-108	heme oxygenase 1	Mus musculus	29-32
18072938-2	2008	Following haem catabolism by HO1 (haem oxygenase 1), they recycle iron back into the plasma through the iron exporter Fpn (ferroportin).	Iron	104-108	heme oxygenase 1	Mus musculus	34-50
17546407-6	2008	The bioavailability of the released iron was confirmed by a 100% increase in L-ferritin protein as well as a 60% decrease of the IRP2 protein levels.	Iron	36-40	iron responsive element binding protein 2	Homo sapiens	129-133
17585373-1	2008	BACKGROUND: Administration of intravenous iron preparations in haemodialysis patients may lead to the appearance of non-transferrin bound iron which can catalyse oxidative damage.	Iron	42-46	transferrin	Homo sapiens	120-131
17585373-1	2008	BACKGROUND: Administration of intravenous iron preparations in haemodialysis patients may lead to the appearance of non-transferrin bound iron which can catalyse oxidative damage.	Iron	138-142	transferrin	Homo sapiens	120-131
17585373-6	2008	After iron infusion, transferrin saturation increased more markedly in non-diabetic subjects from 28% to 185% vs. from 33% to 101% in diabetic patients (P = 0.008).	Iron	6-10	transferrin	Homo sapiens	21-32
18276042-5	2008	In five HH patients, using (58)Fe as a tracer, the rate of iron absorption was increased (P&lt;0.05) and serum non-transferrin bound iron showed a tendency to increase (P=0.06).	Iron	133-137	transferrin	Homo sapiens	115-126
18419598-1	2008	Transferrin and transferrin receptor are two key proteins of iron metabolism that have been identified to be hypoxia-inducible genes.	Iron	61-65	transferrin	Homo sapiens	0-11
18419598-1	2008	Transferrin and transferrin receptor are two key proteins of iron metabolism that have been identified to be hypoxia-inducible genes.	Iron	61-65	transferrin	Homo sapiens	16-27
18363910-4	2008	The Hpt main function is to bind and carry to the liver free haemoglobin for degradation and iron recycling.	Iron	93-97	haptoglobin	Homo sapiens	4-7
18061679-4	2008	It is hypothesized that Fe uptake is blocked by reactive oxygen species generated by FeT(2) or CuT that damage transferrin or transferrin receptor.	Iron	24-26	transferrin	Homo sapiens	126-137
18399843-2	2008	We analysed the effect of iron overload, indicated by high serum ferritin level, on the mobilization of CD34(+) peripheral blood stem cells (PBSCs).	Iron	26-30	CD34 molecule	Homo sapiens	104-108
18278581-1	2008	We have shown previously that iron deprivation significantly stimulates the uptake of non-transferrin ferric iron from ferric citrate by erythroleukemia K562 cells and that this stimulation depends on protein synthesis.	Iron	30-34	transferrin	Homo sapiens	90-101
18363429-7	2008	Furthermore, both DNA-PKcs (DSB repair factor) and 53BP1 (DSB sensing protein) co-localized with gamma-H2AX along the track of dense ionization produced by iron and silicon ions and their focus dissolution kinetics was similar to that of gamma-H2AX.	Iron	156-160	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	18-26
18363429-7	2008	Furthermore, both DNA-PKcs (DSB repair factor) and 53BP1 (DSB sensing protein) co-localized with gamma-H2AX along the track of dense ionization produced by iron and silicon ions and their focus dissolution kinetics was similar to that of gamma-H2AX.	Iron	156-160	BP1	Homo sapiens	53-56
19294996-4	2008	Insulin resistance hepatic iron overload (IR-HIO) is a new condition of hepatic iron overload, characterized by hyperferritinemia with normal or slightly increased transferrin saturation in the absence of hemochromatotic gene mutations.	Iron	27-31	insulin	Homo sapiens	0-7
19294996-4	2008	Insulin resistance hepatic iron overload (IR-HIO) is a new condition of hepatic iron overload, characterized by hyperferritinemia with normal or slightly increased transferrin saturation in the absence of hemochromatotic gene mutations.	Iron	27-31	transferrin	Homo sapiens	164-175
19294996-4	2008	Insulin resistance hepatic iron overload (IR-HIO) is a new condition of hepatic iron overload, characterized by hyperferritinemia with normal or slightly increased transferrin saturation in the absence of hemochromatotic gene mutations.	Iron	80-84	insulin	Homo sapiens	0-7
17662635-1	2008	The mineralisation of 2,4-dichlorophenoxyacetic acid (2,4-D) in the presence of zero-valent iron and hydrogen peroxide (the advanced Fenton process--AFP) whilst being subjected to acoustic or hydrodynamic cavitation is reported.	Iron	92-96	alpha fetoprotein	Homo sapiens	149-152
18275854-3	2008	In addition, AtGRX4 reduced iron accumulation and rescued the lysine auxotrophy of grx5 cells.	Iron	28-32	glutaredoxin 4	Arabidopsis thaliana	13-19
18311908-1	2008	Type II cytochrome P450 (CYP) ligands cause inhibition by direct coordination to the heme iron atom.	Iron	90-94	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	8-23
18311908-1	2008	Type II cytochrome P450 (CYP) ligands cause inhibition by direct coordination to the heme iron atom.	Iron	90-94	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	25-28
18311908-3	2008	The approach to design compounds with diminished CYP inhibition is different depending on whether the compound binds (type II ligand) or not (type I ligand) to the iron atom of the heme group.	Iron	164-168	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-52
18311908-4	2008	In this study, the structural characteristics of nitrogen-containing compounds, which bind to the iron atom in two CYP isoforms (CYP2C9 and CYP3A4), were investigated.	Iron	98-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-118
18311908-4	2008	In this study, the structural characteristics of nitrogen-containing compounds, which bind to the iron atom in two CYP isoforms (CYP2C9 and CYP3A4), were investigated.	Iron	98-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	140-146
18245813-7	2008	Iron depletion of Sprague-Dawley rats increased HIF-1alpha expression, improved glucose clearance, and was associated with up-regulation of insulin receptor and Akt/PKB levels and of glucose transport in hepatic tissue.	Iron	0-4	AKT serine/threonine kinase 1	Rattus norvegicus	161-168
18245813-0	2008	Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver.	Iron	0-4	insulin	Homo sapiens	63-70
18255213-8	2008	A 40% and 52% (P<0.001) protection was observed in caspase-3 activity with 30 and 100 micromol/L IP6, respectively in iron-excess condition.	Iron	118-122	caspase 3	Homo sapiens	51-60
18254628-4	2008	Comprehensive structural analyses throughout this transformation, from primitive orthorhombic (Pccn) to body-centered tetragonal (I4/mcm), reveal a flexing of the framework and a dilation of the channels, with an accompanying subtle distortion of the iron(II) coordination geometry.	Iron	251-255	PPP1R2C family member C	Homo sapiens	130-136
18304497-0	2008	Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.	Iron	23-27	iron-sulfur cluster assembly enzyme	Homo sapiens	60-64
18304497-2	2008	We identified the gene for the iron-sulfur cluster scaffold protein ISCU as a candidate within a region of shared homozygosity among patients with this disease.	Iron	31-35	iron-sulfur cluster assembly enzyme	Homo sapiens	68-72
18304497-4	2008	A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease.	Iron	119-123	iron-sulfur cluster assembly enzyme	Homo sapiens	22-26
18245813-1	2008	Iron depletion improves insulin resistance in patients with nonalcoholic fatty liver disease and diabetes and also stabilizes the hypoxia-inducible factor (HIF)-1, resulting in increased glucose uptake in vitro.	Iron	0-4	insulin	Homo sapiens	24-31
18245813-1	2008	Iron depletion improves insulin resistance in patients with nonalcoholic fatty liver disease and diabetes and also stabilizes the hypoxia-inducible factor (HIF)-1, resulting in increased glucose uptake in vitro.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-162
18245813-2	2008	This study investigated the effect of iron depletion by deferoxamine on insulin signaling and glucose uptake in HepG2 hepatocytes and in rat liver.	Iron	38-42	insulin	Homo sapiens	72-79
18304497-4	2008	A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease.	Iron	119-123	iron-sulfur cluster assembly enzyme	Homo sapiens	50-54
18304497-4	2008	A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease.	Iron	166-170	iron-sulfur cluster assembly enzyme	Homo sapiens	22-26
18245275-0	2008	A ferroxidase encoded by FOX1 contributes to iron assimilation under conditions of poor iron nutrition in Chlamydomonas.	Iron	45-49	RNA binding fox-1 homolog 1	Homo sapiens	25-29
18304497-4	2008	A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease.	Iron	166-170	iron-sulfur cluster assembly enzyme	Homo sapiens	50-54
18304497-4	2008	A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease.	Iron	166-170	iron-sulfur cluster assembly enzyme	Homo sapiens	22-26
18304497-4	2008	A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease.	Iron	166-170	iron-sulfur cluster assembly enzyme	Homo sapiens	50-54
18304497-5	2008	ISCU interacts with the Friedreich ataxia gene product frataxin in iron-sulfur cluster biosynthesis.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
18245275-0	2008	A ferroxidase encoded by FOX1 contributes to iron assimilation under conditions of poor iron nutrition in Chlamydomonas.	Iron	88-92	RNA binding fox-1 homolog 1	Homo sapiens	25-29
18245275-1	2008	When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.	Iron	91-95	RNA binding fox-1 homolog 1	Homo sapiens	26-30
18245275-1	2008	When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.	Iron	91-95	RNA binding fox-1 homolog 1	Homo sapiens	162-166
18245275-1	2008	When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.	Iron	125-129	RNA binding fox-1 homolog 1	Homo sapiens	26-30
18245275-1	2008	When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.	Iron	125-129	RNA binding fox-1 homolog 1	Homo sapiens	26-30
18683628-5	2008	In mice challenged with virulent P. multocida, outer-membrane protein (OMP) extracts of fur cells conferred the same protection as obtained with wild-type cells grown in iron-depleted medium.	Iron	170-174	TolC family protein	Pasteurella multocida	47-69
18403823-1	2008	Hypocalcemia due to hypoparathyroidism (HPT) is a late complication of iron-overloaded patients with b-thalassaemia major (TM).	Iron	71-75	HPT	Homo sapiens	40-43
18403823-3	2008	In the last 20 years we observed heart failure in 2 out of 38 (5.2%) TM patients (aged 18 and 22 years) with hypocalcemia secondary to HPT associated to iron overload.	Iron	153-157	HPT	Homo sapiens	135-138
18473900-1	2008	Transferrin (Trf) is a highly conserved serum glycoprotein mostly known for its iron transport capacity.	Iron	80-84	transferrin	Homo sapiens	0-11
18473900-1	2008	Transferrin (Trf) is a highly conserved serum glycoprotein mostly known for its iron transport capacity.	Iron	80-84	transferrin	Homo sapiens	13-16
18473900-2	2008	As iron is an indispensable nutrient for cell division, Trf and its receptor have long been used as targets of pharmacological intervention mostly for cancer therapy and for diagnosis in inflammation.	Iron	3-7	transferrin	Homo sapiens	56-59
18473900-3	2008	In recent years several independent pieces of work including data from our group, indicated that Trf can also have an iron independent role in the immune system.	Iron	118-122	transferrin	Homo sapiens	97-100
18473900-4	2008	In this article new emerging roles of Trf and its receptor on iron independent processes and in drug delivery are reviewed.	Iron	62-66	transferrin	Homo sapiens	38-41
17981932-7	2008	Notably, ageing was associated with elevated expression of ferritin (heavy chain, +56.2-fold; light chain, +7.3-fold), an important iron storage protein.	Iron	132-136	ferritin heavy chain 1	Rattus norvegicus	59-80
18683628-5	2008	In mice challenged with virulent P. multocida, outer-membrane protein (OMP) extracts of fur cells conferred the same protection as obtained with wild-type cells grown in iron-depleted medium.	Iron	170-174	TolC family protein	Pasteurella multocida	71-74
18336670-6	2008	Ethanol increases transferrin (Tf)-mediated uptake via a receptor-dependent manner, but downregulates the non-Tf-bound iron uptake.	Iron	119-123	transferrin	Homo sapiens	110-112
17902167-2	2008	The transferrin-transferrin receptor pathway is the main route for erythroid iron uptake.	Iron	77-81	transferrin	Homo sapiens	4-15
17902167-2	2008	The transferrin-transferrin receptor pathway is the main route for erythroid iron uptake.	Iron	77-81	transferrin	Homo sapiens	16-27
17902167-9	2008	Thus, macrophages support EP development under transferrin-free conditions by delivering essential iron in the form of metabolizable ferritin.	Iron	99-103	transferrin	Homo sapiens	47-58
18336670-8	2008	In an experimental model, ethanol exposure to the primary cultured-hepatocytes in the presence of iron increased TfR1 expression and (59)Fe-labeled Tf uptake.	Iron	98-102	transferrin	Homo sapiens	113-115
18383103-1	2008	Human transferrin (hTf) is an 80 kDa glycoprotein involved in iron transport from the absorption sites to the sites of storage and utilization.	Iron	62-66	transferrin	Homo sapiens	6-17
18261897-3	2008	We show that DHEA decreased HIF-1alpha accumulation under both "chemical hypoxia" with treatment by the iron chelator deferroxamin and gas hypoxia (1% O2).	Iron	104-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
18287268-2	2008	(18)F-FES uptake has been shown to correlate with ER expression assayed in vitro by radioligand binding; however, immunohistochemistry (IHC) rather than radioligand binding is used most often to measure ER expression in clinical practice.	Iron	6-9	estrogen receptor 1	Homo sapiens	50-52
18287268-2	2008	(18)F-FES uptake has been shown to correlate with ER expression assayed in vitro by radioligand binding; however, immunohistochemistry (IHC) rather than radioligand binding is used most often to measure ER expression in clinical practice.	Iron	6-9	estrogen receptor 1	Homo sapiens	203-205
18297518-3	2008	Recent discoveries have led to the identification of hepcidin as a key regulator of iron metabolism and to the association of non-transferrin bound iron moieties, such as labile plasma iron, with the end organ damage in iron overload states.	Iron	148-152	transferrin	Homo sapiens	130-141
18326317-2	2008	Iron is taken up from the foods by enterocytes of the duodenum and proximal jejunum, and then released into the plasma and transported to whole body by binding to transferrin.	Iron	0-4	transferrin	Homo sapiens	163-174
18297518-3	2008	Recent discoveries have led to the identification of hepcidin as a key regulator of iron metabolism and to the association of non-transferrin bound iron moieties, such as labile plasma iron, with the end organ damage in iron overload states.	Iron	148-152	transferrin	Homo sapiens	130-141
18297518-3	2008	Recent discoveries have led to the identification of hepcidin as a key regulator of iron metabolism and to the association of non-transferrin bound iron moieties, such as labile plasma iron, with the end organ damage in iron overload states.	Iron	148-152	transferrin	Homo sapiens	130-141
18029550-7	2008	In the presence of DOX and (59)Fe-transferrin, iron-trafficking studies demonstrated ferritin-(59)Fe accumulation and decreased cytosolic-(59)Fe incorporation.	Iron	47-51	transferrin	Homo sapiens	34-45
18029550-7	2008	In the presence of DOX and (59)Fe-transferrin, iron-trafficking studies demonstrated ferritin-(59)Fe accumulation and decreased cytosolic-(59)Fe incorporation.	Iron	31-33	transferrin	Homo sapiens	34-45
18029550-7	2008	In the presence of DOX and (59)Fe-transferrin, iron-trafficking studies demonstrated ferritin-(59)Fe accumulation and decreased cytosolic-(59)Fe incorporation.	Iron	98-100	transferrin	Homo sapiens	34-45
18326317-3	2008	Transferrin-bound iron is utilized mainly for erythropoiesis at the bone marrow, in which iron is essential for the formation of heme.	Iron	18-22	transferrin	Homo sapiens	0-11
18326317-3	2008	Transferrin-bound iron is utilized mainly for erythropoiesis at the bone marrow, in which iron is essential for the formation of heme.	Iron	90-94	transferrin	Homo sapiens	0-11
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	176-180	interleukin 1 beta	Homo sapiens	124-132
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	176-180	interleukin 6	Homo sapiens	137-141
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	246-250	interleukin 1 beta	Homo sapiens	124-132
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	246-250	interleukin 6	Homo sapiens	137-141
17912757-1	2008	Fe- and Mn-containing superoxide dismutase (sod) enzymes are closely related and similar in both amino acid sequence and structure, but differ in their mode of oligomerization and in their specificity for the Fe or Mn cofactor.	Iron	0-2	superoxide dismutase 1	Homo sapiens	22-42
17912757-1	2008	Fe- and Mn-containing superoxide dismutase (sod) enzymes are closely related and similar in both amino acid sequence and structure, but differ in their mode of oligomerization and in their specificity for the Fe or Mn cofactor.	Iron	0-2	superoxide dismutase 1	Homo sapiens	44-47
17912757-1	2008	Fe- and Mn-containing superoxide dismutase (sod) enzymes are closely related and similar in both amino acid sequence and structure, but differ in their mode of oligomerization and in their specificity for the Fe or Mn cofactor.	Iron	209-211	superoxide dismutase 1	Homo sapiens	22-42
17912757-1	2008	Fe- and Mn-containing superoxide dismutase (sod) enzymes are closely related and similar in both amino acid sequence and structure, but differ in their mode of oligomerization and in their specificity for the Fe or Mn cofactor.	Iron	209-211	superoxide dismutase 1	Homo sapiens	44-47
18305254-6	2008	These findings provide evidence that impairment of iPLA2beta causes neuroaxonal degeneration, and indicate that the iPLA2beta-/- mouse is an appropriate animal model of human neurodegenerative diseases associated with mutations of the iPLA2beta gene, such as infantile neuroaxonal dystrophy and neurodegeneration with brain iron accumulation.	Iron	324-328	phospholipase A2, group VI	Mus musculus	51-60
18073186-7	2008	Addition of the iron chelator desferrioxamine to reduce the accumulation of ferric iron from heme by HO-1 resulted in blockade of the aggravated oxygen radical production.	Iron	16-20	heme oxygenase 1	Mus musculus	101-105
18073186-10	2008	This study revealed that simvastatin-induced HO-1 led to increased NF-kappaB activation and superoxides production in the neuronal cells when exposed to LPS, and iron production may play a role in such a response.	Iron	162-166	heme oxygenase 1	Mus musculus	45-49
18073186-2	2008	However, we had demonstrated that simvastatin-induced HO-1 increased apoptosis of Neuro 2A cells in glucose deprivation, and iron production from HO-1 activity may be responsible for the toxicity.	Iron	125-129	heme oxygenase 1	Mus musculus	146-150
18061585-4	2008	We further reveal that the capability of flavonoids to bind efficiently intracellular iron and their lipophilicity are essential for HIF-1alpha induction.	Iron	86-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-143
18225897-3	2008	Ti2HsTf (2 equiv) binds the transferrin receptor TfR1 with Kd1 = 6.3 +/- 0.4 nM and Kd2 = 410 +/- 150 nM, values that are the tightest yet measured for a metal other than iron but weaker than the corresponding ones for Fe2HsTf due to both slightly slower on rates and slightly faster off rates.	Iron	171-175	transferrin	Homo sapiens	28-39
18061585-5	2008	Despite the ability of flavonoids to stabilize HIF-1alpha, the transcriptional activity of HIF-1 induced by flavonoids was significantly lower than that observed with the iron chelator and known HIF-1 inducer, desferrioxamine (DFO).	Iron	171-175	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-96
18282105-1	2008	The level of available iron in the mammalian host is extremely low, and pathogenic microbes must compete with host proteins such as transferrin for iron.	Iron	148-152	transferrin	Homo sapiens	132-143
18242889-1	2008	Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes the rate-limiting step in the degradation of heme to biliverdin, carbon monoxide and iron.	Iron	147-151	heme oxygenase 1	Mus musculus	0-16
18242889-1	2008	Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes the rate-limiting step in the degradation of heme to biliverdin, carbon monoxide and iron.	Iron	147-151	heme oxygenase 1	Mus musculus	18-22
18254965-0	2008	Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron.	Iron	93-97	transferrin	Rattus norvegicus	75-86
18254965-2	2008	While most iron circulates in blood as transferrin-bound iron, non-transferrin-bound iron (NTBI) also becomes elevated and contributes to toxicity in the setting of iron overload.	Iron	11-15	transferrin	Rattus norvegicus	39-50
18254965-2	2008	While most iron circulates in blood as transferrin-bound iron, non-transferrin-bound iron (NTBI) also becomes elevated and contributes to toxicity in the setting of iron overload.	Iron	57-61	transferrin	Rattus norvegicus	39-50
18254965-2	2008	While most iron circulates in blood as transferrin-bound iron, non-transferrin-bound iron (NTBI) also becomes elevated and contributes to toxicity in the setting of iron overload.	Iron	57-61	transferrin	Rattus norvegicus	39-50
18254965-2	2008	While most iron circulates in blood as transferrin-bound iron, non-transferrin-bound iron (NTBI) also becomes elevated and contributes to toxicity in the setting of iron overload.	Iron	57-61	transferrin	Rattus norvegicus	39-50
18202189-1	2008	Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation.	Iron	220-224	phospholipase A2 group VI	Homo sapiens	17-23
18202189-1	2008	Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation.	Iron	220-224	phospholipase A2 group VI	Homo sapiens	92-103
18202189-10	2008	iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation.	Iron	143-147	phospholipase A2, group VI	Mus musculus	0-11
17822790-1	2008	Iron regulatory protein 2 (IRP2) binds to iron-responsive elements (IREs) to regulate the translation and stability of mRNAs encoding several proteins involved in mammalian iron homeostasis.	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	0-25
18060852-8	2008	Furthermore, we have shown unequivocally that CBS binds one mole of heme per subunit by determining both the heme and the iron content of the enzyme.	Iron	122-126	cystathionine beta-synthase	Homo sapiens	46-49
17336986-4	2008	Serum iron parameters were assessed, including non-transferrin bound iron (NTBI) that has recently been found in conditions of iron overload.	Iron	69-73	transferrin	Homo sapiens	51-62
17336986-4	2008	Serum iron parameters were assessed, including non-transferrin bound iron (NTBI) that has recently been found in conditions of iron overload.	Iron	69-73	transferrin	Homo sapiens	51-62
17822790-1	2008	Iron regulatory protein 2 (IRP2) binds to iron-responsive elements (IREs) to regulate the translation and stability of mRNAs encoding several proteins involved in mammalian iron homeostasis.	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	27-31
17822790-1	2008	Iron regulatory protein 2 (IRP2) binds to iron-responsive elements (IREs) to regulate the translation and stability of mRNAs encoding several proteins involved in mammalian iron homeostasis.	Iron	173-177	iron responsive element binding protein 2	Homo sapiens	0-25
17822790-1	2008	Iron regulatory protein 2 (IRP2) binds to iron-responsive elements (IREs) to regulate the translation and stability of mRNAs encoding several proteins involved in mammalian iron homeostasis.	Iron	173-177	iron responsive element binding protein 2	Homo sapiens	27-31
17822790-2	2008	Increases in cellular iron stimulate the polyubiquitylation and proteasomal degradation of IRP2.	Iron	22-26	iron responsive element binding protein 2	Homo sapiens	91-95
17822790-3	2008	One study has suggested that haem-oxidized IRP2 ubiquitin ligase-1 (HOIL-1) binds to a unique 73-amino acid (aa) domain in IRP2 in an iron-dependent manner to regulate IRP2 polyubiquitylation and degradation.	Iron	134-138	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	29-66
18162612-5	2008	However, although the Ang II group had significantly higher absolute iron content (increased 103%, P&lt;0.001) in the aortic arch compared with the saline group, the p38 MAPK inhibitor (SB-239063, 150 mg/kg/d) treatment group did not (increased 6%, NS).	Iron	69-73	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	22-28
18187051-1	2008	We partially characterized the transferrin-independent iron uptake (Tf-IU) of neuronal and glial cells in the previous report.	Iron	55-59	transferrin	Homo sapiens	31-42
17822790-3	2008	One study has suggested that haem-oxidized IRP2 ubiquitin ligase-1 (HOIL-1) binds to a unique 73-amino acid (aa) domain in IRP2 in an iron-dependent manner to regulate IRP2 polyubiquitylation and degradation.	Iron	134-138	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	68-74
17822790-3	2008	One study has suggested that haem-oxidized IRP2 ubiquitin ligase-1 (HOIL-1) binds to a unique 73-amino acid (aa) domain in IRP2 in an iron-dependent manner to regulate IRP2 polyubiquitylation and degradation.	Iron	134-138	iron responsive element binding protein 2	Homo sapiens	43-47
17822790-3	2008	One study has suggested that haem-oxidized IRP2 ubiquitin ligase-1 (HOIL-1) binds to a unique 73-amino acid (aa) domain in IRP2 in an iron-dependent manner to regulate IRP2 polyubiquitylation and degradation.	Iron	134-138	iron responsive element binding protein 2	Homo sapiens	123-127
17822790-4	2008	Other studies have questioned the role of the 73-aa domain in iron-dependent IRP2 degradation.	Iron	62-66	iron responsive element binding protein 2	Homo sapiens	77-81
17822790-5	2008	We investigated the potential role of HOIL-1 in the iron-mediated degradation of IRP2 in human embryonic kidney 293 (HEK293) cells.	Iron	52-56	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	38-44
17822790-5	2008	We investigated the potential role of HOIL-1 in the iron-mediated degradation of IRP2 in human embryonic kidney 293 (HEK293) cells.	Iron	52-56	iron responsive element binding protein 2	Homo sapiens	81-85
17822790-6	2008	We found that transiently expressed HOIL-1 and IRP2 interact via the 73-aa domain, but this interaction is not iron-dependent, nor does it enhance the rate of IRP2 degradation by iron.	Iron	179-183	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	36-42
17356788-3	2008	Human apoB bound to bovine spleen, horse spleen, and canine liver ferritins, but did not bind to bovine apoferritin, even after incorporation of iron into it.	Iron	145-149	apolipoprotein B	Homo sapiens	6-10
17822790-6	2008	We found that transiently expressed HOIL-1 and IRP2 interact via the 73-aa domain, but this interaction is not iron-dependent, nor does it enhance the rate of IRP2 degradation by iron.	Iron	179-183	iron responsive element binding protein 2	Homo sapiens	47-51
18163543-9	2008	Consistent with an oxidative mechanism, iron overload enhanced porphyria as well as general liver injury in Ahr (+/+) and Ahr (+/-) mice but had no interactive effect in Ahr (-/-) .	Iron	40-44	aryl-hydrocarbon receptor	Mus musculus	108-111
18163543-9	2008	Consistent with an oxidative mechanism, iron overload enhanced porphyria as well as general liver injury in Ahr (+/+) and Ahr (+/-) mice but had no interactive effect in Ahr (-/-) .	Iron	40-44	aryl-hydrocarbon receptor	Mus musculus	122-125
18163543-9	2008	Consistent with an oxidative mechanism, iron overload enhanced porphyria as well as general liver injury in Ahr (+/+) and Ahr (+/-) mice but had no interactive effect in Ahr (-/-) .	Iron	40-44	aryl-hydrocarbon receptor	Mus musculus	122-125
18163543-10	2008	In contrast, when iron-treated mice received, instead of TCDD, the heme precursor 5-aminolevulinic acid (ALA), causing uroporphyia in Ahr (+/+) mice (242-fold rise in uroporphyrins), elevation of uroporphyrins I and III (42-fold) also occurred in Ahr (-/-) mice and was seemingly associated with AHR-independent expression of Cyp1a2.	Iron	18-22	aryl-hydrocarbon receptor	Mus musculus	134-137
18163543-10	2008	In contrast, when iron-treated mice received, instead of TCDD, the heme precursor 5-aminolevulinic acid (ALA), causing uroporphyia in Ahr (+/+) mice (242-fold rise in uroporphyrins), elevation of uroporphyrins I and III (42-fold) also occurred in Ahr (-/-) mice and was seemingly associated with AHR-independent expression of Cyp1a2.	Iron	18-22	aryl-hydrocarbon receptor	Mus musculus	247-250
18163543-10	2008	In contrast, when iron-treated mice received, instead of TCDD, the heme precursor 5-aminolevulinic acid (ALA), causing uroporphyia in Ahr (+/+) mice (242-fold rise in uroporphyrins), elevation of uroporphyrins I and III (42-fold) also occurred in Ahr (-/-) mice and was seemingly associated with AHR-independent expression of Cyp1a2.	Iron	18-22	aryl-hydrocarbon receptor	Mus musculus	296-299
18191835-12	2008	Fe(+2) is an important co-factor utilized by the iron-dependent isomerohydrolase RPE65 in the retinoid visual cycle.	Iron	49-53	retinal pigment epithelium 65	Mus musculus	81-86
18261896-1	2008	Iron homeostasis in animal cells is controlled post-transcriptionally by the iron regulatory proteins IRP1 and IRP2.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	111-115
18261896-1	2008	Iron homeostasis in animal cells is controlled post-transcriptionally by the iron regulatory proteins IRP1 and IRP2.	Iron	77-81	iron responsive element binding protein 2	Homo sapiens	111-115
18023482-1	2008	Backbone dynamics of the camphor monoxygenase cytochrome P450(cam) (CYP101) as a function of oxidation/ligation state of the heme iron were investigated via hydrogen/deuterium exchange (H/D exchange) as monitored by mass spectrometry.	Iron	130-134	calmodulin 3	Homo sapiens	46-66
18216316-1	2008	The Dialysis Patients Response to IV Iron with Elevated Ferritin (DRIVE) study demonstrated the efficacy of intravenous ferric gluconate to improve hemoglobin levels in anemic hemodialysis patients who were receiving adequate epoetin doses and who had ferritin levels between 500 and 1200 ng/ml and transferrin saturation (TSAT) &lt; or = 25%.	Iron	37-41	erythropoietin	Homo sapiens	226-233
18216316-1	2008	The Dialysis Patients Response to IV Iron with Elevated Ferritin (DRIVE) study demonstrated the efficacy of intravenous ferric gluconate to improve hemoglobin levels in anemic hemodialysis patients who were receiving adequate epoetin doses and who had ferritin levels between 500 and 1200 ng/ml and transferrin saturation (TSAT) &lt; or = 25%.	Iron	37-41	transferrin	Homo sapiens	299-310
17990009-0	2008	Terephthalamide-containing ligands: fast removal of iron from transferrin.	Iron	52-56	transferrin	Homo sapiens	62-73
17990009-1	2008	The mechanism and effectiveness of iron removal from transferrin by three series of new potential therapeutic iron sequestering agents have been analyzed with regard to the structures of the chelators.	Iron	35-39	transferrin	Homo sapiens	53-64
17990009-1	2008	The mechanism and effectiveness of iron removal from transferrin by three series of new potential therapeutic iron sequestering agents have been analyzed with regard to the structures of the chelators.	Iron	110-114	transferrin	Homo sapiens	53-64
17990009-3	2008	Rates of iron removal from transferrin were determined spectrophotometrically for the ten ligands, which all efficiently acquire ferric ion from diferric transferrin with a hyperbolic dependence on ligand concentration (saturation kinetics).	Iron	9-13	transferrin	Homo sapiens	27-38
17990009-3	2008	Rates of iron removal from transferrin were determined spectrophotometrically for the ten ligands, which all efficiently acquire ferric ion from diferric transferrin with a hyperbolic dependence on ligand concentration (saturation kinetics).	Iron	9-13	transferrin	Homo sapiens	154-165
18817181-2	2008	We chose a mine of Iron and Copper named Hame Kasi that located western north of Hamedan city as a polluted area.	Iron	19-23	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	46-50
18227247-5	2008	The sequence is located 20-44 (32.5) bp 5" of the ptxR P2 promoter, and overlaps a potential binding site for the iron-starvation sigma factor PvdS.	Iron	114-118	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	50-54
18226225-5	2008	Truncated versions of IRP2 were expressed in H1299 cells and analyzed for their response to iron.	Iron	92-96	iron responsive element binding protein 2	Homo sapiens	22-26
18201676-1	2008	Developing erythroid cells are dependent on transferrin (Tf) to acquire iron in amounts sufficient for hemoglobin production.	Iron	72-76	transferrin	Homo sapiens	44-55
18201676-1	2008	Developing erythroid cells are dependent on transferrin (Tf) to acquire iron in amounts sufficient for hemoglobin production.	Iron	72-76	transferrin	Homo sapiens	57-59
18201676-7	2008	Thus, although under normal conditions, Tf is the major route of iron uptake, Ft and hemin, but not iron-chelator complexes, may serve as alternative iron sources under Tf-poor conditions.	Iron	65-69	transferrin	Homo sapiens	40-42
18226225-0	2008	Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	30-34
18226225-1	2008	BACKGROUND: Iron regulatory protein 2 (IRP2), a post-transcriptional regulator of cellular iron metabolism, undergoes iron-dependent degradation via the ubiquitin-proteasome pathway.	Iron	91-95	iron responsive element binding protein 2	Homo sapiens	12-37
18364461-1	2008	To ascertain the possible roles of nuclear erythroid 2 p45-related factor 2 (Nrf2), a key transcription factor of phase 2 drug-metabolizing enzymes, in renal cellular defense against oxidative stress, wild-type and Nrf2-knockout -/- mice were treated with ferric nitrilotriacetate (Fe-NTA) at doses of 3 or 6 mg iron/kg body weight.	Iron	312-316	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
18226225-1	2008	BACKGROUND: Iron regulatory protein 2 (IRP2), a post-transcriptional regulator of cellular iron metabolism, undergoes iron-dependent degradation via the ubiquitin-proteasome pathway.	Iron	91-95	iron responsive element binding protein 2	Homo sapiens	39-43
18226225-6	2008	Deletion mutants lacking the entire C-terminal domain 4 (amino acids 719-963) of IRP2 remained stable following iron treatments.	Iron	112-116	iron responsive element binding protein 2	Homo sapiens	81-85
18226225-1	2008	BACKGROUND: Iron regulatory protein 2 (IRP2), a post-transcriptional regulator of cellular iron metabolism, undergoes iron-dependent degradation via the ubiquitin-proteasome pathway.	Iron	118-122	iron responsive element binding protein 2	Homo sapiens	12-37
18226225-1	2008	BACKGROUND: Iron regulatory protein 2 (IRP2), a post-transcriptional regulator of cellular iron metabolism, undergoes iron-dependent degradation via the ubiquitin-proteasome pathway.	Iron	118-122	iron responsive element binding protein 2	Homo sapiens	39-43
18226225-7	2008	Moreover, the replacement of domain 4 of IRP1 with the corresponding region of IRP2 sensitized the chimerical IRP11-3/IRP24 protein to iron-dependent degradation, while the reverse manipulation gave rise to a stable chimerical IRP21-3/IRP14 protein.	Iron	135-139	iron responsive element binding protein 2	Homo sapiens	79-83
18226225-8	2008	The deletion of just 26 or 34 C-terminal amino acids stabilized IRP2 against iron.	Iron	77-81	iron responsive element binding protein 2	Homo sapiens	64-68
18226225-10	2008	CONCLUSION: Our data suggest that the C-terminus of IRP2 contains elements that are necessary but not sufficient for iron-dependent degradation.	Iron	117-121	iron responsive element binding protein 2	Homo sapiens	52-56
21201302-1	2008	In the title compound, [Fe(C(5)H(5))(C(6)H(16)P(2))(CO)](C(12)H(13)BOP), the Fe(II) ion adopts a three-legged piano-stool geometry, with Fe Cg = 1.721 (5)A (Cg = the centroid defined by the C atoms of the cyclo-penta-dienyl ring).	Iron	24-26	BOP	Homo sapiens	67-70
18042465-4	2008	In addition, the blockage of HO activity with the iron chelator DFO or with HO-1 siRNA inhibited the CoPP-induced expression of p53.	Iron	50-54	tumor protein p53	Homo sapiens	128-131
18042465-7	2008	Based on these results, we conclude that HO activity is involved in the regulation of p53 expression in a ROS-independent mechanism, and also suggest that the expression of p53 in ARPE-19 cells is associated with heme metabolites such as biliverdin/bilirubin, carbon monoxide, and iron produced by the activity of HO.	Iron	281-285	tumor protein p53	Homo sapiens	173-176
17919118-0	2008	Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy.	Iron	32-36	transferrin	Homo sapiens	42-53
17919118-8	2008	Again, the simultaneous presence of both a bidentate chelator and DFO was found to enhance the rate of iron chelation from transferrin at clinically relevant chelator levels.	Iron	103-107	transferrin	Homo sapiens	123-134
17919118-9	2008	Deferiprone was found to be particularly effective at "shuttling" iron from transferrin to DFO, probably as a result of its small size and relative low affinity for iron compared with other analogous HPO chelators.	Iron	66-70	transferrin	Homo sapiens	76-87
18092806-7	2008	Mass spectrometry analysis indicates that Nile Red is metabolized sequentially by CYP3A4 to the N-monoethyl and N-desethyl products, confirming that the immediate vicinity of the heme iron is one binding site.	Iron	184-188	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
19115025-7	2008	Statistically significant differences were found between the mild and severe groups on comparing mean age, duration of stay, quantity of alcohol and parameters of chronic consumption (ferritine, fe, VCM, UBE, AST, bilirubin and Mg) for AST and bilirubin.	Iron	29-31	solute carrier family 17 member 5	Homo sapiens	209-212
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Iron	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	118-124
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Iron	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	121-124
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	187-190
19066079-6	2008	In addition, MT-1 also reduced cell death induced by iron in cultured astrocytes.	Iron	53-57	metallothionein 1	Rattus norvegicus	13-17
18183929-1	2008	Lactoferrin (Lf) is an iron binding glycoprotein of the transferrin family that is expressed in most biological fluids and is a major component of mammals" innate immune system.	Iron	23-27	transferrin	Homo sapiens	56-67
19115025-7	2008	Statistically significant differences were found between the mild and severe groups on comparing mean age, duration of stay, quantity of alcohol and parameters of chronic consumption (ferritine, fe, VCM, UBE, AST, bilirubin and Mg) for AST and bilirubin.	Iron	29-31	solute carrier family 17 member 5	Homo sapiens	236-239
18852484-11	2008	Catalase activity from erythrocytes was increased 5 h after supplementation with AA plus iron.	Iron	89-93	catalase	Homo sapiens	0-8
18986010-0	2008	Anemia management in peritoneal dialysis patients: can an iron supplement maintain a normal transferrin saturation and hemoglobin level?	Iron	58-62	transferrin	Homo sapiens	92-103
18986010-3	2008	At the same time, chronic inflammatory diseases reduce the release of iron from storage sites, resulting in low transferrin saturation (Fe+ sat%).	Iron	70-74	transferrin	Homo sapiens	112-123
18986010-3	2008	At the same time, chronic inflammatory diseases reduce the release of iron from storage sites, resulting in low transferrin saturation (Fe+ sat%).	Iron	136-139	transferrin	Homo sapiens	112-123
18256996-0	2008	Periodic iron nanomineralization in human serum transferrin fibrils.	Iron	9-13	transferrin	Homo sapiens	48-59
18024960-1	2008	Ferritin is a ubiquitous protein that sequesters iron and protects cells from iron toxicity.	Iron	49-53	Ferritin	Caenorhabditis elegans	0-8
18024960-1	2008	Ferritin is a ubiquitous protein that sequesters iron and protects cells from iron toxicity.	Iron	78-82	Ferritin	Caenorhabditis elegans	0-8
18024960-2	2008	Caenorhabditis elegans express two ferritins, FTN-1 and FTN-2, which are transcriptionally regulated by iron.	Iron	104-108	Ferritin	Caenorhabditis elegans	56-61
18024960-3	2008	To identify the cis-acting sequences and proteins required for iron-dependent regulation of ftn-1 and ftn-2 expression, we generated transcriptional GFP reporters corresponding to 5 "-upstream sequences of the ftn-1 and ftn-2 genes.	Iron	63-67	Ferritin	Caenorhabditis elegans	102-107
18024960-3	2008	To identify the cis-acting sequences and proteins required for iron-dependent regulation of ftn-1 and ftn-2 expression, we generated transcriptional GFP reporters corresponding to 5 "-upstream sequences of the ftn-1 and ftn-2 genes.	Iron	63-67	Ferritin	Caenorhabditis elegans	220-225
18024960-10	2008	These data demonstrate that the activation of ftn-1 and ftn-2 transcription by iron requires ELT-2 and that the IDE functions as an iron-dependent enhancer in intestine.	Iron	79-83	Ferritin	Caenorhabditis elegans	56-61
19734120-3	2008	The NADH-dependent system has been suggested to be involved in non-transferrin-bound iron (NTBI) reduction and uptake.	Iron	85-89	transferrin	Homo sapiens	67-78
20041071-10	2008	Iron/TIBC ratio x 100 gave percentage of transferrin saturation value.	Iron	0-4	transferrin	Homo sapiens	41-52
17910970-9	2008	Iron and iron-bearing clays reduced the effective elution rates of both RDX and TNT.	Iron	0-4	chromosome 16 open reading frame 82	Homo sapiens	80-83
17869549-5	2008	The release of s-hemojuvelin is negatively regulated by both transferrin-bound iron (holo-Tf) and non-transferrin-bound iron (FAC), indicating s-hemojuvelin could be one of the mediators of hepcidin regulation by iron.	Iron	79-83	transferrin	Homo sapiens	61-72
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	24-28	transferrin	Homo sapiens	0-2
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	24-28	transferrin	Homo sapiens	13-15
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	104-108	transferrin	Homo sapiens	0-2
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	104-108	transferrin	Homo sapiens	13-15
17872962-3	2008	Iron-free Tf (apo-Tf) is then brought back to the cell surface and dissociates from TfR.	Iron	0-4	transferrin	Homo sapiens	10-12
17872962-3	2008	Iron-free Tf (apo-Tf) is then brought back to the cell surface and dissociates from TfR.	Iron	0-4	transferrin	Homo sapiens	18-20
18212498-40	2008	iron sucrose 100 mg per week can maintain serum iron parameters and Hb levels in Chinese patients on maintenance hemodialysis and can permit reductions in the required dose of EPO.	Iron	0-4	erythropoietin	Homo sapiens	176-179
17910970-9	2008	Iron and iron-bearing clays reduced the effective elution rates of both RDX and TNT.	Iron	9-13	chromosome 16 open reading frame 82	Homo sapiens	80-83
19126966-8	2008	Altered glycosylation of the acute phase protein transferrin plays an important role in iron homeostasis.	Iron	88-92	transferrin	Homo sapiens	49-60
18484792-11	2008	In all cases to date, the actual CNS pathology of RLS demonstrates reduced iron stores, in a pattern that suggests that the homeostatic control of iron is altered, not just that there is not enough iron entering the brain.	Iron	75-79	RLS1	Homo sapiens	50-53
18484792-11	2008	In all cases to date, the actual CNS pathology of RLS demonstrates reduced iron stores, in a pattern that suggests that the homeostatic control of iron is altered, not just that there is not enough iron entering the brain.	Iron	147-151	RLS1	Homo sapiens	50-53
18484792-11	2008	In all cases to date, the actual CNS pathology of RLS demonstrates reduced iron stores, in a pattern that suggests that the homeostatic control of iron is altered, not just that there is not enough iron entering the brain.	Iron	147-151	RLS1	Homo sapiens	50-53
18690875-5	2008	In this regard, we proved that while AZT and its monophosphorylated derivative AZTMP were unable to chelate iron, the triphosphate form AZTTP displayed a significant capacity to remove iron from transferrin.	Iron	185-189	transferrin	Homo sapiens	195-206
18473833-11	2008	Particularly, mutations of cytochrome b gene of ETC or changes in iron homeostasis by mitochondrial enzyme aconitase alter sensitivity of MDR1 and regulate resistance level to anti-parasitic drugs.	Iron	66-70	ATP binding cassette subfamily B member 1	Homo sapiens	138-142
19141392-1	2008	Proliferating cells have an absolute requirement for iron, which is delivered by transferrin with subsequent intracellular transport via the transferrin receptor.	Iron	53-57	transferrin receptor	Sus scrofa	141-161
17962718-0	2008	Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in human endometrial stromal and epithelial cells is regulated by interferon-gamma but not iron.	Iron	177-181	vascular cell adhesion molecule 1	Homo sapiens	52-85
18045552-9	2008	Calreticulin levels correlated with intracellular iron increase and were associated with protection from oxidative stress.	Iron	50-54	calreticulin	Homo sapiens	0-12
18195524-3	2008	We have studied the iron-mediated regulatory mechanism of a regulator of the iron metabolism, IRP2, and found that IRP2 is regulated by an oxidation-induced degradation, which is triggered by heme and molecular oxygen.	Iron	20-24	iron responsive element binding protein 2	Homo sapiens	94-98
18195524-3	2008	We have studied the iron-mediated regulatory mechanism of a regulator of the iron metabolism, IRP2, and found that IRP2 is regulated by an oxidation-induced degradation, which is triggered by heme and molecular oxygen.	Iron	20-24	iron responsive element binding protein 2	Homo sapiens	115-119
18195524-3	2008	We have studied the iron-mediated regulatory mechanism of a regulator of the iron metabolism, IRP2, and found that IRP2 is regulated by an oxidation-induced degradation, which is triggered by heme and molecular oxygen.	Iron	77-81	iron responsive element binding protein 2	Homo sapiens	94-98
18195524-3	2008	We have studied the iron-mediated regulatory mechanism of a regulator of the iron metabolism, IRP2, and found that IRP2 is regulated by an oxidation-induced degradation, which is triggered by heme and molecular oxygen.	Iron	77-81	iron responsive element binding protein 2	Homo sapiens	115-119
18195524-5	2008	Considering that heme is generated in the matrix of mitochondria, our observation that IRP2 is regulated by the protein degradation pathway triggered by the heme-mediated oxidation indicates the involvement and importance of mitochondria in cellular iron sensing as well as the regulation of the iron metabolism.	Iron	250-254	iron responsive element binding protein 2	Homo sapiens	87-91
18195524-5	2008	Considering that heme is generated in the matrix of mitochondria, our observation that IRP2 is regulated by the protein degradation pathway triggered by the heme-mediated oxidation indicates the involvement and importance of mitochondria in cellular iron sensing as well as the regulation of the iron metabolism.	Iron	296-300	iron responsive element binding protein 2	Homo sapiens	87-91
17962718-3	2008	The purpose of this study was to investigate iron incorporation by human endometrial cells and to test whether iron may stimulate expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1.	Iron	111-115	vascular cell adhesion molecule 1	Homo sapiens	189-229
19074076-6	2008	Body iron status is routinely assessed by serum ferritin and transferrin saturation, but there is a need of reliable tools for locating iron accumulation in patients.	Iron	5-9	transferrin	Homo sapiens	61-72
18582596-1	2008	The two mammalian iron regulatory proteins, IRP1 and IRP2, are post-transcriptional regulators of cellular iron homeostasis.	Iron	18-22	iron responsive element binding protein 2	Homo sapiens	53-57
18274990-3	2008	In thalassemia patients, non transferrin bound iron (NTBI) and free hemoglobin (Hb) are present in plasma and may accelerate atherogenesis, but its progression may be inhibited by iron chelators.	Iron	47-51	transferrin	Homo sapiens	29-40
18274990-3	2008	In thalassemia patients, non transferrin bound iron (NTBI) and free hemoglobin (Hb) are present in plasma and may accelerate atherogenesis, but its progression may be inhibited by iron chelators.	Iron	180-184	transferrin	Homo sapiens	29-40
18274990-5	2008	Non transferrin bound iron and sera from subjects with hemochromatosis induced endothelial activation with expression of vascular adhesion molecules and endothelial inflammatory chemokines.	Iron	22-26	transferrin	Homo sapiens	4-15
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	22-26	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	62-75
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	22-26	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	77-82
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	176-180	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	62-75
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	176-180	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	77-82
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	70-74	transferrin	Homo sapiens	6-17
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	70-74	transferrin	Homo sapiens	20-22
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	76-78	transferrin	Homo sapiens	6-17
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	76-78	transferrin	Homo sapiens	20-22
18582596-1	2008	The two mammalian iron regulatory proteins, IRP1 and IRP2, are post-transcriptional regulators of cellular iron homeostasis.	Iron	107-111	iron responsive element binding protein 2	Homo sapiens	53-57
18691669-2	2008	Although MTf has a high-affinity Fe-binding site that is practically identical to that of serum Tf, the protein does not play an essential role in Fe homeostasis and its precise molecular function remains unclear.	Iron	33-35	transferrin	Homo sapiens	10-12
18582596-3	2008	Whereas IRP1 levels remain nearly constant, IRP2 is rapidly degraded by the proteasome in iron-replete cells.	Iron	90-94	iron responsive element binding protein 2	Homo sapiens	44-48
18691669-7	2008	Although four different iron-loaded forms were observed with serum Tf, only two forms were found with MTf, the apo-form and the N-monoferric holo-protein, suggesting a single high-affinity site.	Iron	24-28	transferrin	Homo sapiens	67-69
18582596-4	2008	In non iron-loaded H1299 human lung cancer cells, the decay of transfected hemagglutinin-tagged IRP2 was significantly antagonized by addition of not only proteasomal, but also lysosomal inhibitors.	Iron	7-11	iron responsive element binding protein 2	Homo sapiens	96-100
18582596-6	2008	These data uncover an alternative, iron independent, mechanism of IRP2 degradation via the lysosomal pathway.	Iron	35-39	iron responsive element binding protein 2	Homo sapiens	66-70
18582596-9	2008	Together with previous data obtained in the presence of iron excess, these results show that the parallel degradation pathways through lysosomes and the proteasome that are active on IRP2 under normal growth conditions are preferentially shifted to the proteasome when iron becomes plentiful.	Iron	56-60	iron responsive element binding protein 2	Homo sapiens	183-187
18582596-9	2008	Together with previous data obtained in the presence of iron excess, these results show that the parallel degradation pathways through lysosomes and the proteasome that are active on IRP2 under normal growth conditions are preferentially shifted to the proteasome when iron becomes plentiful.	Iron	269-273	iron responsive element binding protein 2	Homo sapiens	183-187
17939020-9	2008	The results suggest that BSA may take part in non-transferrin bound iron transfer.	Iron	68-72	transferrin	Homo sapiens	50-61
17906879-0	2008	Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera.	Iron	32-36	transferrin	Homo sapiens	14-25
17906879-1	2008	Despite its importance in iron-overload diseases, little is known about the composition of plasma non-transferrin-bound iron (NTBI).	Iron	120-124	transferrin	Homo sapiens	102-113
18544952-10	2008	CONCLUSION: Our findings suggest that the elevation in serum ALT levels during therapy is caused by iron overload which may be induced by PEG-IFNalpha-2a.	Iron	100-104	interferon alpha 1	Homo sapiens	142-150
17939020-1	2008	The serum albumin is the most abundant protein in blood plasma and the iron is essential for many cellular processes.	Iron	71-75	albumin	Homo sapiens	4-17
18971604-8	2008	The iron deficiency group had significantly lower hemoglobin, mean corpuscular hemoglobin, mean corpuscular volume, reticulocyte hemoglobin content, ferritin, soluble transferrin receptors, iron and higher red cell distribution width, transferrin, and transferrin saturation (P&lt;0.05) compared with the normal iron store group.	Iron	4-8	transferrin	Homo sapiens	167-178
18089442-1	2008	Intravenous iron supplementation is a recognized therapy for anemia in chronic hemodialysis patients, especially in those treated with erythropoietin.	Iron	12-16	erythropoietin	Homo sapiens	135-149
17959319-4	2008	We postulate therefore that the plasma protein transferrin acts protectively in these events, by holding iron in containment and reducing oxidative stress.	Iron	105-109	transferrin	Homo sapiens	47-58
18094771-4	2008	The pin holder was made from magnetic soft iron and contained more than 6000 pillars on its surface.	Iron	43-47	dynein light chain LC8-type 1	Homo sapiens	4-7
17766053-3	2008	IL-6 controls systemic iron homeostasis through hepcidin, which is produced mainly by hepatocytes.	Iron	23-27	interleukin 6	Homo sapiens	0-4
17959319-1	2008	Transferrin is a plasma protein with the primary role of transporting iron through the body and delivering it to the cells that utilize it.	Iron	70-74	transferrin	Homo sapiens	0-11
17959319-2	2008	Because free ionic iron is very toxic by creating free radicals, the importance of transferrin lies in its antioxidant properties.	Iron	19-23	transferrin	Homo sapiens	83-94
18971604-8	2008	The iron deficiency group had significantly lower hemoglobin, mean corpuscular hemoglobin, mean corpuscular volume, reticulocyte hemoglobin content, ferritin, soluble transferrin receptors, iron and higher red cell distribution width, transferrin, and transferrin saturation (P&lt;0.05) compared with the normal iron store group.	Iron	4-8	transferrin	Homo sapiens	235-246
18971604-8	2008	The iron deficiency group had significantly lower hemoglobin, mean corpuscular hemoglobin, mean corpuscular volume, reticulocyte hemoglobin content, ferritin, soluble transferrin receptors, iron and higher red cell distribution width, transferrin, and transferrin saturation (P&lt;0.05) compared with the normal iron store group.	Iron	4-8	transferrin	Homo sapiens	235-246
18584481-3	2008	In comparing the highest to the lowest tertiles, the risk was odds ratio (OR) = 0.3 [95% confidence interval (CI) = 0.1-0.6] for iron; 3.2 (95% CI = 1.3-8.1) for total iron binding capacity (TIBC), which measures the concentration of the iron delivery protein transferrin; and 0.4 (95% CI = 0.2-0.9) for transferrin saturation (iron/TIBC x 100).	Iron	129-133	transferrin	Homo sapiens	260-271
18087169-2	2008	Further, vitamin C has been advocated as a potential adjuvant to erythropoietin by virtue of its capacity to improve iron utilization.	Iron	117-121	erythropoietin	Homo sapiens	65-79
18094727-7	2008	Proinflammatory cytokines antagonize the action of EPO by exerting an inhibitory effect on erythroid progenitor cells and by disrupting iron metabolism (a process in which hepcidin has a central role).	Iron	136-140	erythropoietin	Homo sapiens	51-54
18584481-3	2008	In comparing the highest to the lowest tertiles, the risk was odds ratio (OR) = 0.3 [95% confidence interval (CI) = 0.1-0.6] for iron; 3.2 (95% CI = 1.3-8.1) for total iron binding capacity (TIBC), which measures the concentration of the iron delivery protein transferrin; and 0.4 (95% CI = 0.2-0.9) for transferrin saturation (iron/TIBC x 100).	Iron	129-133	transferrin	Homo sapiens	304-315
18047264-3	2007	The multifunctional compounds show activity against human AChE, are able to inhibit the AChE-induced amyloid-beta aggregation, and chelate metals, such as iron and copper.	Iron	155-159	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-62
20016736-0	2008	Effects of various metal ions on the gene expression of iron exporter ferroportin-1 in J774 macrophages.	Iron	56-60	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	70-83
20016736-2	2008	Ferroportin-1 (FPN1) is a transporter protein that is known to mediate iron export from macrophages.	Iron	71-75	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-13
20016736-2	2008	Ferroportin-1 (FPN1) is a transporter protein that is known to mediate iron export from macrophages.	Iron	71-75	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-19
20016736-11	2008	In conclusion, our study results demonstrate that divalent metals differentially regulate FPN1 expression in macrophages and indicate a potential interaction of divalent metals with the FPN1-mediated iron export in macrophages.	Iron	200-204	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	186-190
18710026-2	2008	It was established by EPR spectroscopy method that STZ administration reduced transferrin levels in the blood as well as pools of iron associated with blood transferrin and with ferritin in the heart and aorta of rats with hyperglycaemia.	Iron	130-134	transferrin	Rattus norvegicus	157-168
17852830-1	2008	The aim of this study was to evaluate the relationship between the erythropoietin (EPO) concentration and both the advanced cellular indices reflecting the haemoglobin contents of red blood cells and reticulocytes and the serum markers of iron status.	Iron	239-243	erythropoietin	Homo sapiens	67-81
17852830-1	2008	The aim of this study was to evaluate the relationship between the erythropoietin (EPO) concentration and both the advanced cellular indices reflecting the haemoglobin contents of red blood cells and reticulocytes and the serum markers of iron status.	Iron	239-243	erythropoietin	Homo sapiens	83-86
17852830-8	2008	This could be explained by subclinical iron deficiency being accompanied by a compensatory EPO response.	Iron	39-43	erythropoietin	Homo sapiens	91-94
17928392-10	2008	Addition of the iron chelator desferrioxamine also resulted in blockade of the aggravated apoptosis, which implies that iron production from HO-1 activity may play an important role in the increased apoptosis in response to glucose deprivation in neuronal cells pretreated with simvastatin.	Iron	16-20	heme oxygenase 1	Mus musculus	141-145
17928392-10	2008	Addition of the iron chelator desferrioxamine also resulted in blockade of the aggravated apoptosis, which implies that iron production from HO-1 activity may play an important role in the increased apoptosis in response to glucose deprivation in neuronal cells pretreated with simvastatin.	Iron	120-124	heme oxygenase 1	Mus musculus	141-145
18245906-0	2008	[Effect of chronic iron overload on atherosclerosis lesion in apolipoprotein E knockout mice].	Iron	19-23	apolipoprotein E	Mus musculus	62-78
18245906-9	2008	CONCLUSION: Chronic iron overload may promote the development of AS lesion in the ApoE knockout mice, in which the increased oxidative stress and lipid oxidation may involve.	Iron	20-24	apolipoprotein E	Mus musculus	82-86
17760563-1	2007	Mammalian IRPs (iron regulatory proteins), IRP1 and IRP2, are cytosolic RNA-binding proteins that post-transcriptionally control the mRNA of proteins involved in storage, transport, and utilization of iron.	Iron	16-20	iron responsive element binding protein 2	Homo sapiens	52-56
20641669-5	2004	The Tf receptor (TfR) mediates the internalization of iron-loaded Tf into cells (4, 5).	Iron	54-58	transferrin	Homo sapiens	4-6
17760563-2	2007	In iron-replete cells, IRP2 undergoes degradation by the ubiquitin/proteasome pathway.	Iron	3-7	iron responsive element binding protein 2	Homo sapiens	23-27
17760563-3	2007	Binding of haem to a 73aa-Domain (73-amino-acid domain) that is unique in IRP2 has been previously proposed as the initial iron-sensing mechanism.	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	74-78
17760563-6	2007	Iron-independent cleavage of IRP2 within the 73aa-Domain also occurs in lung cancer (H1299) cells.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	29-33
17471497-9	2007	In summary, our results indicate that iron chelator-induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1.	Iron	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
17471497-9	2007	In summary, our results indicate that iron chelator-induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1.	Iron	38-42	mitogen-activated protein kinase 3	Homo sapiens	107-113
17471497-0	2007	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1.	Iron	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
17471497-9	2007	In summary, our results indicate that iron chelator-induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1.	Iron	38-42	mitogen-activated protein kinase 1	Homo sapiens	118-121
17471497-0	2007	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1.	Iron	38-42	nuclear factor kappa B subunit 1	Homo sapiens	98-107
17471497-0	2007	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1.	Iron	38-42	mitogen-activated protein kinase 3	Homo sapiens	121-127
18048327-3	2007	In the oxidation of PPh(3), the reactivity order of 1-NCCH(3) &gt; 1-OOCCF(3) &gt; 1-N(3) &gt; 1"-SR was observed, reflecting a decrease in the electrophilicity of iron(IV)-oxo unit upon replacement of CH(3)CN with an anionic axial ligand.	Iron	164-168	caveolin 1	Homo sapiens	20-26
17471497-0	2007	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1.	Iron	38-42	mitogen-activated protein kinase 1	Homo sapiens	133-136
17471497-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
17471497-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways.	Iron	33-37	mitogen-activated protein kinase 3	Homo sapiens	208-214
17471497-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways.	Iron	33-37	mitogen-activated protein kinase 1	Homo sapiens	219-222
17954932-0	2007	Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.	Iron	14-18	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	130-135
17884229-1	2007	The human transferrin receptor (hTfR1) is a membrane-bound protein involved in transferrin (Tf)-mediated iron uptake and is highly expressed on malignant cells.	Iron	105-109	transferrin	Homo sapiens	10-21
17884229-1	2007	The human transferrin receptor (hTfR1) is a membrane-bound protein involved in transferrin (Tf)-mediated iron uptake and is highly expressed on malignant cells.	Iron	105-109	transferrin	Homo sapiens	79-90
17884229-1	2007	The human transferrin receptor (hTfR1) is a membrane-bound protein involved in transferrin (Tf)-mediated iron uptake and is highly expressed on malignant cells.	Iron	105-109	transferrin	Homo sapiens	33-35
17884229-2	2007	A second version of the receptor (hTfR2) also mediates Tf-dependent iron import.	Iron	68-72	transferrin	Homo sapiens	35-37
18201586-0	2007	Effect of intravenous iron supplementation on hepatic cytochrome P450 3A4 activity in hemodialysis patients: a prospective, open-label study.	Iron	22-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-73
17961176-8	2007	Fasting insulin levels were significantly increased in patients with beta-thalassaemia major compared to controls (P = 0.01), and had significant negative correlation to MRI-derived liver iron content (r = -0.733, P = 0.03).	Iron	188-192	insulin	Homo sapiens	8-15
18043060-10	2007	Endogenous erythropoietin decreased from 261 +/- 130 pg/ml to 190 +/- 49 pg/ml 2 weeks after intravenous iron treatment (P = 0.050, not significant after Bonferroni correction).	Iron	105-109	erythropoietin	Homo sapiens	11-25
18201586-3	2007	OBJECTIVE: The purpose of this study was to investigate the effect of IV iron supplementation on hepatic is CYP3A4 activity in HD patients.	Iron	73-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
18201586-11	2007	After IV iron replacement, mean (SEM) CYP3A4 activity increased in these 7 HD patients (120.1% [67.1%]); P = 0.04) and it was not statistically different from that of controls (1.50 [0.36] vs 2.10 [0.26]).	Iron	9-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-44
18201586-13	2007	However, in a subset of HD patients with low baseline CYP3A4 activity indicated by low ERMBT values, IV iron supplementation was associated with a potentially clinically relevant increase in hepatic CYP3A4 activity.	Iron	104-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-60
18201586-13	2007	However, in a subset of HD patients with low baseline CYP3A4 activity indicated by low ERMBT values, IV iron supplementation was associated with a potentially clinically relevant increase in hepatic CYP3A4 activity.	Iron	104-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	199-205
18297887-4	2007	Iron is taken up in the small intestine by divalent metal transporter-1 and is either stored by ferritin inside the mucosal cell or transported to the systemic circulation by ferroportin, while being oxidized by hephaestin to be incorporated into transferrin.	Iron	0-4	transferrin	Homo sapiens	247-258
18297888-5	2007	In view of the importance of non-transferrin-bound plasma iron (NTBI) in iron toxicity and its rapid cellular uptake, it may play an important role in the harmful effects of iron in infection, and this is illustrated by the infectious complications of parenteral iron therapy in tropical countries.	Iron	58-62	transferrin	Homo sapiens	33-44
18297890-2	2007	Acquisition of iron from host sources, such as ferritin, transferrin, and heme compounds, is discussed.	Iron	15-19	transferrin	Homo sapiens	57-68
18297891-5	2007	There is evidence to suggest that the apparent detrimental effect of iron supplementation may vary according to levels of antecedent iron status, the presence of hemoglobinopathies and glucose-6-phosphate dehydrogenase (G6PD) deficiency, and other host genetic variants, such as variants in haptoglobin.	Iron	69-73	haptoglobin	Homo sapiens	291-302
18297896-6	2007	An efficacy study of iron-fortified salt in dewormed school-aged children in Cote d"Ivoire, where the prevalence of malaria parasitemia was 55%, found no change in hemoglobin after 6 months, but serum ferritin increased and transferrin receptor decreased significantly, and the increase in body iron and estimated iron absorbed compared favorably with the results of a study of similar design in Morocco, where the prevalence of iron-deficiency anemia decreased from 30% to 5% after 10 months.	Iron	21-25	transferrin	Homo sapiens	224-235
17763462-0	2007	Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	34-42
17893127-7	2007	Mechanistically, IFN-gamma controls S. aureus infection via IFN-gamma receptor, most likely through stimulation of intrinsic endothelial antibacterial mechanisms but independent of processes that deprive bacteria of intracellular L-tryptophan or iron.	Iron	246-250	interferon gamma	Homo sapiens	17-26
17893127-7	2007	Mechanistically, IFN-gamma controls S. aureus infection via IFN-gamma receptor, most likely through stimulation of intrinsic endothelial antibacterial mechanisms but independent of processes that deprive bacteria of intracellular L-tryptophan or iron.	Iron	246-250	interferon gamma	Homo sapiens	60-69
18201586-1	2007	BACKGROUND: Cytochrome P450 (CYP) 3A4 is an enzyme with activity dependent on the reduction of heme iron that is responsible for the metabolism of many drugs.	Iron	100-104	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	12-37
17953660-1	2007	Iron, an essential element for all cells of the body, including those of the brain, is transported bound to transferrin in the blood and the general extracellular fluid of the body.	Iron	0-4	transferrin	Homo sapiens	108-119
17516501-1	2007	It has been suggested that Hephaestin (Heph), a newly discovered ceruloplasmin homologue, is necessary for iron egress from the enterocytes into circulation via interacting with ferroportin1 (FP1).	Iron	107-111	solute carrier family 40 member 1	Rattus norvegicus	178-190
17516501-1	2007	It has been suggested that Hephaestin (Heph), a newly discovered ceruloplasmin homologue, is necessary for iron egress from the enterocytes into circulation via interacting with ferroportin1 (FP1).	Iron	107-111	solute carrier family 40 member 1	Rattus norvegicus	192-195
17516501-2	2007	Based on the putative function of Heph, and the similarity between the process of iron transport in the enterocytes and that in the blood-brain barrier (BBB) cells, it has also been proposed that Heph plays a similar role in exporting iron from the BBB cells and other brain cells as it works in the enterocytes via interacting with FP1.	Iron	82-86	solute carrier family 40 member 1	Rattus norvegicus	333-336
17516501-2	2007	Based on the putative function of Heph, and the similarity between the process of iron transport in the enterocytes and that in the blood-brain barrier (BBB) cells, it has also been proposed that Heph plays a similar role in exporting iron from the BBB cells and other brain cells as it works in the enterocytes via interacting with FP1.	Iron	235-239	solute carrier family 40 member 1	Rattus norvegicus	333-336
18025230-5	2007	Fe chelation inhibits TNF-driven transcription of Vcam-1, Icam-1, and E-selectin, as assessed using luciferase reporter assays.	Iron	0-2	tumor necrosis factor	Mus musculus	22-25
18025230-5	2007	Fe chelation inhibits TNF-driven transcription of Vcam-1, Icam-1, and E-selectin, as assessed using luciferase reporter assays.	Iron	0-2	selectin, endothelial cell	Mus musculus	70-80
18025230-1	2007	Heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) catalyzes the degradation of free heme into biliverdin, via a reaction that releases iron (Fe) and carbon monoxide.	Iron	136-140	heme oxygenase 1	Mus musculus	0-22
18025230-1	2007	Heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) catalyzes the degradation of free heme into biliverdin, via a reaction that releases iron (Fe) and carbon monoxide.	Iron	136-140	heme oxygenase 1	Mus musculus	39-44
18025230-1	2007	Heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) catalyzes the degradation of free heme into biliverdin, via a reaction that releases iron (Fe) and carbon monoxide.	Iron	142-144	heme oxygenase 1	Mus musculus	0-22
18025230-1	2007	Heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) catalyzes the degradation of free heme into biliverdin, via a reaction that releases iron (Fe) and carbon monoxide.	Iron	142-144	heme oxygenase 1	Mus musculus	39-44
18025230-2	2007	We report that HO-1 down-regulates the proinflammatory phenotype associated with endothelial cell (EC) activation by reducing intracellular nonprotein-bound Fe (labile Fe).	Iron	157-159	heme oxygenase 1	Mus musculus	15-19
18025230-3	2007	EC isolated from Hmox1(-/-) mice have higher levels of intracellular labile Fe and reactive oxygen species (ROS) as compared with EC isolated from Hmox1(+/+) mice.	Iron	76-78	heme oxygenase 1	Mus musculus	17-22
17953660-2	2007	The demonstration of transferrin receptors on brain capillary endothelial cells (BCECs) more than 20 years ago provided the evidence for the now accepted view that the first step in blood to brain transport of iron is receptor-mediated endocytosis of transferrin.	Iron	210-214	transferrin	Homo sapiens	21-32
17953660-2	2007	The demonstration of transferrin receptors on brain capillary endothelial cells (BCECs) more than 20 years ago provided the evidence for the now accepted view that the first step in blood to brain transport of iron is receptor-mediated endocytosis of transferrin.	Iron	210-214	transferrin	Homo sapiens	251-262
17953660-5	2007	They provide new evidence on how iron is released from transferrin on the abluminal surface of BCECs, including the role of astrocytes in this process, how iron is transported in brain extracellular fluid, and how iron is taken up by neurons and glial cells.	Iron	33-37	transferrin	Homo sapiens	55-66
17953660-5	2007	They provide new evidence on how iron is released from transferrin on the abluminal surface of BCECs, including the role of astrocytes in this process, how iron is transported in brain extracellular fluid, and how iron is taken up by neurons and glial cells.	Iron	156-160	transferrin	Homo sapiens	55-66
17953660-5	2007	They provide new evidence on how iron is released from transferrin on the abluminal surface of BCECs, including the role of astrocytes in this process, how iron is transported in brain extracellular fluid, and how iron is taken up by neurons and glial cells.	Iron	156-160	transferrin	Homo sapiens	55-66
17953660-7	2007	Instead, iron is probably released from transferrin on the abluminal surface of these cells by the action of citrate and ATP that are released by astrocytes, which form a very close relationship with BCECs.	Iron	9-13	transferrin	Homo sapiens	40-51
17953660-8	2007	Complexes of iron with citrate and ATP can then circulate in brain extracellular fluid and may be taken up in these low-molecular weight forms by all types of brain cells or be bound by transferrin and taken up by cells which express transferrin receptors.	Iron	13-17	transferrin	Homo sapiens	186-197
17953660-8	2007	Complexes of iron with citrate and ATP can then circulate in brain extracellular fluid and may be taken up in these low-molecular weight forms by all types of brain cells or be bound by transferrin and taken up by cells which express transferrin receptors.	Iron	13-17	transferrin	Homo sapiens	234-245
17953660-9	2007	Some iron most likely also circulates bound to transferrin, as neurons contain both transferrin receptors and divalent metal transporter 1 and can take up transferrin-bound iron.	Iron	5-9	transferrin	Homo sapiens	47-58
17953660-9	2007	Some iron most likely also circulates bound to transferrin, as neurons contain both transferrin receptors and divalent metal transporter 1 and can take up transferrin-bound iron.	Iron	5-9	transferrin	Homo sapiens	84-95
17953660-9	2007	Some iron most likely also circulates bound to transferrin, as neurons contain both transferrin receptors and divalent metal transporter 1 and can take up transferrin-bound iron.	Iron	5-9	transferrin	Homo sapiens	84-95
17953660-9	2007	Some iron most likely also circulates bound to transferrin, as neurons contain both transferrin receptors and divalent metal transporter 1 and can take up transferrin-bound iron.	Iron	173-177	transferrin	Homo sapiens	47-58
17953660-13	2007	Their source of iron is probably that released from transferrin on the abluminal surface of BCECs.	Iron	16-20	transferrin	Homo sapiens	52-63
17953660-16	2007	They probably take up non-transferrin bound iron that gets incorporated in newly synthesized transferrin, which may play an important role for intracellular iron transport.	Iron	44-48	transferrin	Homo sapiens	26-37
17953660-16	2007	They probably take up non-transferrin bound iron that gets incorporated in newly synthesized transferrin, which may play an important role for intracellular iron transport.	Iron	44-48	transferrin	Homo sapiens	93-104
17953660-16	2007	They probably take up non-transferrin bound iron that gets incorporated in newly synthesized transferrin, which may play an important role for intracellular iron transport.	Iron	157-161	transferrin	Homo sapiens	26-37
17953660-16	2007	They probably take up non-transferrin bound iron that gets incorporated in newly synthesized transferrin, which may play an important role for intracellular iron transport.	Iron	157-161	transferrin	Homo sapiens	93-104
17948968-7	2007	Qualitative information about the relative calcium binding affinities of the N- and C-terminal domains of CaM and about the relative iron binding affinities of the N- and C-terminal domains of transferrin was also obtained using the new protocol.	Iron	133-137	transferrin	Homo sapiens	193-204
17992281-0	2007	[(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.	Iron	12-14	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
17980612-2	2007	Arabidopsis thaliana AtFer1 ferritin, one of the best characterized plant ferritin isoforms to date, strongly accumulates upon treatment with excess iron, via a nitric oxide-mediated pathway.	Iron	149-153	ferretin 1	Arabidopsis thaliana	21-27
17980612-9	2007	These results suggest that AtFer1 ferritin isoform is functionally involved in events leading to the onset of age-dependent senescence in Arabidopsis and that its iron-detoxification function during senescence is required when reactive oxygen species accumulate.	Iron	163-167	ferretin 1	Arabidopsis thaliana	27-33
17901053-7	2007	Such results indicate the possibility that modulation of cellular Bach1 concentrations will have variable effects among the genes coordinately regulated by maf recognition/antioxidant response elements in iron/oxygen/antioxidant metabolism.	Iron	205-209	BTB domain and CNC homolog 1	Homo sapiens	66-71
17674967-2	2007	In such cases, haptoglobin and ferritin are up-regulated to sequester free Hb and iron in the circulation.	Iron	82-86	haptoglobin	Homo sapiens	15-26
18075082-7	2007	In the transformation of PCE and TCE, the formation of unidentified product(s) is most significant in Co(II)-added FeS batches.	Iron	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
18075107-2	2007	In this study, we have found a new pathway of Cr(VI) photoreduction in the presence of Fe-(III) that is influenced by two inorganic electrolytes (i.e., NO3- and Cl-) and the pH.	Iron	87-89	NBL1, DAN family BMP antagonist	Homo sapiens	152-155
18075107-8	2007	This study suggests that the photolysis of NO3- and Fe-Cl complex may contribute significantly to Cr(VI) reduction in surface water that receives electroplating wastewater containing high levels of NO3-, Cl-, and Fe-(III).	Iron	52-54	NBL1, DAN family BMP antagonist	Homo sapiens	198-201
17644369-10	2007	Interestingly, we found that the mRNA and protein levels of GRP78 were decreased in iron-fed C57BL/6 mice, while they were unchanged in iron-fed 129sv mice.	Iron	84-88	heat shock protein 5	Mus musculus	60-65
17644736-6	2007	The iron-responsive region that we have mapped is the same region required for the in vitro response of HepG2 cells to stimulation with bone morphogenetic proteins and differs from the LPS/IL-6 responsive area.	Iron	4-8	interleukin 6	Homo sapiens	189-193
17822515-6	2007	This article discusses three cellular regulators (p53, p21 and TRAIL) induced in synovial tissue that are important for iron metabolism.	Iron	120-124	tumor protein p53	Homo sapiens	50-53
17893044-8	2007	The doxorubicin-mediated decrease in cFLIP(S) and XIAP and the TRAIL-induced apoptosis were prevented by pretreatment with an iron chelator, indicating that expression of these proteins was affected by free radical generation upon interaction of iron with doxorubicin.	Iron	126-130	TNF superfamily member 10	Homo sapiens	63-68
17893044-8	2007	The doxorubicin-mediated decrease in cFLIP(S) and XIAP and the TRAIL-induced apoptosis were prevented by pretreatment with an iron chelator, indicating that expression of these proteins was affected by free radical generation upon interaction of iron with doxorubicin.	Iron	246-250	TNF superfamily member 10	Homo sapiens	63-68
17822515-6	2007	This article discusses three cellular regulators (p53, p21 and TRAIL) induced in synovial tissue that are important for iron metabolism.	Iron	120-124	TNF superfamily member 10	Homo sapiens	63-68
18078582-4	2007	Lactoferrin is an iron-binding bilobal protein of the transferrin family found in neutrophilic leukocytes and external secretion of mammals.	Iron	18-22	transferrin	Homo sapiens	54-65
17854465-0	2007	Hepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis C. BACKGROUND/AIM: Insulin resistance and hepatic iron overload are frequently demonstrated in hepatitis C virus (HCV)-related liver diseases.	Iron	8-12	insulin	Homo sapiens	49-56
17854465-0	2007	Hepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis C. BACKGROUND/AIM: Insulin resistance and hepatic iron overload are frequently demonstrated in hepatitis C virus (HCV)-related liver diseases.	Iron	8-12	insulin	Homo sapiens	122-129
17854465-1	2007	We investigated the relationship between insulin resistance and hepatic iron deposition in patients with chronic HCV infection.	Iron	72-76	insulin	Homo sapiens	41-48
17854465-3	2007	RESULTS: The levels of plasma immunoreactive insulin (IRI) and HOMA-IR were significantly correlated with serum ferritin levels and the grade of hepatic iron deposition (P = 0.003).Although IRI and HOMA-IR increased in parallel with the development of hepatic fibrosis, insulin resistance (HOMA-IR &gt; 2) was observed in 11 (26.2%) of 42 patients even without severe fibrosis (F0-2).	Iron	153-157	insulin	Homo sapiens	45-52
17854465-5	2007	CONCLUSION: Hepatic iron overload may be associated with insulin resistance in patients with chronic hepatitis C, especially in patients with mild to moderate fibrosis.	Iron	20-24	insulin	Homo sapiens	57-64
17701061-6	2007	It is demonstrated that the high-valent iron complex [(TPA)Cl-Fe(V)=O](2+) is capable of stereospecific alkane chlorination, based on an ionic rather than on a radical pathway.	Iron	40-44	plasminogen activator, tissue type	Homo sapiens	55-58
17942782-7	2007	A rapid rise in total serum iron was followed by a slower, less prominent rise in transferrin-bound iron.	Iron	100-104	transferrin	Homo sapiens	82-93
18006953-2	2007	The major symptoms of PKAN include the onset before the age of 20 years, progressive pyramidal and extrapyramidal signs, retinitis pigmentosa, optic atrophy, dementia, and iron depositions in the globus pallidus.	Iron	172-176	pantothenate kinase 2	Homo sapiens	22-26
17804076-3	2007	Cytochrome c also loads iron into recombinant human H-chain (rHF), human L-chain (rLF), and A. vinelandii bacterioferritin (AvBF).	Iron	24-28	cytochrome c, somatic	Homo sapiens	0-12
17914965-9	2007	Increased hepatic iron stores in CHC were related to resistance to IFN/ribavirin treatment.	Iron	18-22	interferon alpha 1	Homo sapiens	67-70
17625226-6	2007	Results indicate that the primary function of ferritin FtMt is not involved in storing cellular or body iron, but its association with cell types characterized by high metabolic activity and oxygen consumption suggests a role in protecting mitochondria from iron-dependent oxidative damage.	Iron	258-262	ferritin mitochondrial	Mus musculus	55-59
17719088-1	2007	In order to probe the DNA-helicate interactions responsible for the DNA binding and remarkable changes of the DNA secondary structure induced by a tetracationic bi-metallo helicate [Fe(2)(L(1))(3)](4+) (L(1)=C(25)H(20)N(4)), we have designed and synthesised derivatives with hydrophobic methyl groups at different positions on the ligand backbone.	Iron	182-184	immunoglobulin kappa variable 1-16	Homo sapiens	188-192
17719088-1	2007	In order to probe the DNA-helicate interactions responsible for the DNA binding and remarkable changes of the DNA secondary structure induced by a tetracationic bi-metallo helicate [Fe(2)(L(1))(3)](4+) (L(1)=C(25)H(20)N(4)), we have designed and synthesised derivatives with hydrophobic methyl groups at different positions on the ligand backbone.	Iron	182-184	immunoglobulin kappa variable 1-16	Homo sapiens	203-207
17367855-2	2007	We recently described a persistent bone marrow dysplasia with unique dysplastic and inflammatory features developing in individuals previously exposed to benzene (BID) [Irons RD, Lv L, Gross SA, Ye X, Bao L, Wang XQ, et al.	Iron	169-174	BH3 interacting domain death agonist	Homo sapiens	163-166
17943138-8	2007	In addition, EPO may act indirectly by inducing iron depletion and thereby inhibiting iron-dependent oxidative injury.	Iron	48-52	erythropoietin	Homo sapiens	13-16
17943138-8	2007	In addition, EPO may act indirectly by inducing iron depletion and thereby inhibiting iron-dependent oxidative injury.	Iron	86-90	erythropoietin	Homo sapiens	13-16
17704954-2	2007	iron treatment reduces erythropoietin (EPO) dose in paediatric haemodialysis patients.	Iron	0-4	erythropoietin	Homo sapiens	23-37
17551833-4	2007	Astrocytes do not appear to have a high metabolic requirement for iron yet they possess transporters for transferrin, haemin and non-transferrin-bound iron.	Iron	151-155	transferrin	Homo sapiens	133-144
17921041-10	2007	Post mortem retinas from patients with AMD have more iron and the iron carrier transferrin than age-matched controls.	Iron	66-70	transferrin	Homo sapiens	79-90
17921041-14	2007	Levels of the iron carrier transferrin are high in the aqueous and vitreous humors.	Iron	14-18	transferrin	Homo sapiens	27-38
17915953-2	2007	In the process of heme degradation, HO-1 receives the electrons necessary for catalysis from the flavoprotein NADPH cytochrome P450 reductase (CPR), releasing free iron and carbon monoxide.	Iron	164-168	cytochrome p450 oxidoreductase	Homo sapiens	116-141
17915953-2	2007	In the process of heme degradation, HO-1 receives the electrons necessary for catalysis from the flavoprotein NADPH cytochrome P450 reductase (CPR), releasing free iron and carbon monoxide.	Iron	164-168	cytochrome p450 oxidoreductase	Homo sapiens	143-146
18024118-2	2007	Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes.	Iron	71-75	solute carrier family 11 member 1	Homo sapiens	0-6
17473933-6	2007	The crypt program suggests that as crypt cells differentiate and migrate into the absorptive zone they absorb iron from the diet at levels inverse to the amount of iron taken up from transferrin.	Iron	164-168	transferrin	Homo sapiens	183-194
17714436-9	2007	Ferrioxamine B coupled to a fluorescent moiety, FOB-nitrobenz-2-oxa-1,3-diazole, used as a Sit1-dependent iron source, accumulated in the vacuolar lumen even in mutants displaying a steady-state accumulation of Sit1 at the plasma membrane or in endosomal compartments.	Iron	106-110	siderophore transporter	Saccharomyces cerevisiae S288C	91-95
17867686-6	2007	The MII-S thiolate bonds systematically decrease in length across the series (Mn-S &gt; Fe-S &gt; Co-S &gt; Ni-S approximately Cu-S &lt; Zn-S) with exceptions occurring upon the occupation of sigma* orbitals.	Iron	88-92	solute carrier family 5 member 5	Homo sapiens	108-112
17704954-2	2007	iron treatment reduces erythropoietin (EPO) dose in paediatric haemodialysis patients.	Iron	0-4	erythropoietin	Homo sapiens	39-42
17949489-9	2007	RESULTS: Genes with up-regulated expression after iron overload in both skeletal and heart muscle included angiopoietin-like 4, pyruvate dehydrogenase kinase 4 and calgranulin A and B.	Iron	50-54	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	128-159
17631934-9	2007	In conclusion, our findings add to the evidence that iron chelators can inhibit HIV-1 transcription by deregulating CDK2 and CDK9.	Iron	53-57	cyclin dependent kinase 9	Homo sapiens	125-129
17949489-9	2007	RESULTS: Genes with up-regulated expression after iron overload in both skeletal and heart muscle included angiopoietin-like 4, pyruvate dehydrogenase kinase 4 and calgranulin A and B.	Iron	50-54	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	164-183
17949489-10	2007	The expression of transferrin receptor, heat shock protein 1B and DnaJ homolog B1 were down-regulated by iron in both muscle types.	Iron	105-109	heat shock protein 1B	Mus musculus	40-61
17826766-6	2007	In addition, we report that ectopic iron addition activates OPA1 cleavage, whereas zinc inhibits this process.	Iron	36-40	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	60-64
17826766-7	2007	These results suggest that the ATP-dependent OPA1 processing plays a central role in correlating the energetic metabolism to mitochondrial dynamic and might be involved in the pathophysiology of diseases associated to excess of iron or depletion of zinc and ATP.	Iron	228-232	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	45-49
17595334-5	2007	FES is phosphorylated on tyrosine residues in cells that carry KIT(D816V) mutation, and this phosphorylation is KIT dependent.	Iron	0-3	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	63-68
17510944-1	2007	Converging evidence from clinical observations, brain imaging and pathological findings strongly indicate impaired brain iron regulation in restless legs syndrome (RLS).	Iron	121-125	RLS1	Homo sapiens	164-167
17683978-17	2007	The results from a partial least-square regression analysis predicted that both PAHs and a group of metals including Fe and Mn contributed to IL-6 and IL-8 induction.	Iron	117-119	interleukin 6	Homo sapiens	142-146
17683978-17	2007	The results from a partial least-square regression analysis predicted that both PAHs and a group of metals including Fe and Mn contributed to IL-6 and IL-8 induction.	Iron	117-119	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
17892986-12	2007	CONCLUSIONS: In anemic patients with CHF, correction of anemia with EPO and oral iron over 1 year lead to an improvement in LV systolic function, LV remodeling, BNP levels, and PAP compared with a control group in which only oral iron was used.	Iron	230-234	erythropoietin	Homo sapiens	68-71
17854133-1	2007	Patients with alcoholic liver disease frequently exhibit increased body iron stores, as reflected by elevated serum iron indices (transferrin saturation, ferritin) and hepatic iron concentration.	Iron	116-120	transferrin	Homo sapiens	130-141
17854133-1	2007	Patients with alcoholic liver disease frequently exhibit increased body iron stores, as reflected by elevated serum iron indices (transferrin saturation, ferritin) and hepatic iron concentration.	Iron	116-120	transferrin	Homo sapiens	130-141
17670894-0	2007	Non-transferrin-bound iron reaches mitochondria by a chelator-inaccessible mechanism: biological and clinical implications.	Iron	22-26	transferrin	Homo sapiens	4-15
17670894-1	2007	Non-transferrin-bound iron, commonly found in the plasma of iron-overloaded individuals, permeates into cells via pathways independent of the transferrin receptor.	Iron	22-26	transferrin	Homo sapiens	4-15
17670894-1	2007	Non-transferrin-bound iron, commonly found in the plasma of iron-overloaded individuals, permeates into cells via pathways independent of the transferrin receptor.	Iron	60-64	transferrin	Homo sapiens	4-15
17670894-5	2007	We observed that 1) penetration of non-transferrin-bound iron into the cytosol and subsequently into mitochondria occurs with barely detectable delay and 2) loading of the cytosol with high-affinity iron-binding chelators does not abrogate iron uptake into mitochondria.	Iron	57-61	transferrin	Homo sapiens	39-50
17670894-5	2007	We observed that 1) penetration of non-transferrin-bound iron into the cytosol and subsequently into mitochondria occurs with barely detectable delay and 2) loading of the cytosol with high-affinity iron-binding chelators does not abrogate iron uptake into mitochondria.	Iron	199-203	transferrin	Homo sapiens	39-50
17670894-5	2007	We observed that 1) penetration of non-transferrin-bound iron into the cytosol and subsequently into mitochondria occurs with barely detectable delay and 2) loading of the cytosol with high-affinity iron-binding chelators does not abrogate iron uptake into mitochondria.	Iron	199-203	transferrin	Homo sapiens	39-50
17670894-6	2007	Therefore, a fraction of non-transferrin-bound iron acquired by cells reaches the mitochondria in a nonlabile form.	Iron	47-51	transferrin	Homo sapiens	29-40
17901898-1	2007	Lactoferrin (LTF) is a multifunctional iron-binding protein that is also capable of binding other divalent metal cations, especially Zn2+.	Iron	39-43	lactotransferrin	Homo sapiens	0-11
17901898-1	2007	Lactoferrin (LTF) is a multifunctional iron-binding protein that is also capable of binding other divalent metal cations, especially Zn2+.	Iron	39-43	lactotransferrin	Homo sapiens	13-16
17595334-5	2007	FES is phosphorylated on tyrosine residues in cells that carry KIT(D816V) mutation, and this phosphorylation is KIT dependent.	Iron	0-3	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	63-66
17571084-6	2007	Furthermore, incubation of cells with the iron chelator, desferioxamine, not only blocked the activities of caspases 3 and 6, but also affected NHE1 promoter and protein expression in a manner similar to zVAD-fmk.	Iron	42-46	caspase 3	Homo sapiens	108-124
17713653-3	2007	Transferrin, a metalloprotein involved in iron transport, has been characterized as an intrinsic eye protein.	Iron	42-46	serotransferrin	Bos taurus	0-11
17571084-0	2007	Oxidative repression of NHE1 gene expression involves iron-mediated caspase activity.	Iron	54-58	solute carrier family 9 member A1	Homo sapiens	24-28
17571084-6	2007	Furthermore, incubation of cells with the iron chelator, desferioxamine, not only blocked the activities of caspases 3 and 6, but also affected NHE1 promoter and protein expression in a manner similar to zVAD-fmk.	Iron	42-46	solute carrier family 9 member A1	Homo sapiens	144-148
17571084-7	2007	These data show that a mild oxidative stress represses NHE1 promoter activity and expression via an early oxidation phase blocked by reducing agents, and a late phase requiring an iron-dependent increase in caspases 3 and 6 activities.	Iron	180-184	solute carrier family 9 member A1	Homo sapiens	55-59
17571084-7	2007	These data show that a mild oxidative stress represses NHE1 promoter activity and expression via an early oxidation phase blocked by reducing agents, and a late phase requiring an iron-dependent increase in caspases 3 and 6 activities.	Iron	180-184	caspase 3	Homo sapiens	207-223
17660359-0	2007	FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii.	Iron	145-149	uncharacterized protein	Chlamydomonas reinhardtii	6-10
17883261-7	2007	Noncytotoxic concentrations of subway PM (but not CB, TiO2, or DEPs) induced a time- and dose-dependent increase in TNFalpha and MIP-2 production by RAW 264.7 cells, in a manner involving, at least in part, PM iron content (34% inhibition of TNF production 8 h after stimulation of RAW 264.7 cells with 10 microg/cm2 RER particles pretreated with deferoxamine).	Iron	210-214	tumor necrosis factor	Mus musculus	116-124
17660359-7	2007	Genetic analysis suggests that the secreted proteins FEA1 and FEA2 facilitate high-affinity iron uptake, perhaps by concentrating iron in the vicinity of the cell.	Iron	92-96	uncharacterized protein	Chlamydomonas reinhardtii	62-66
17660359-7	2007	Genetic analysis suggests that the secreted proteins FEA1 and FEA2 facilitate high-affinity iron uptake, perhaps by concentrating iron in the vicinity of the cell.	Iron	130-134	uncharacterized protein	Chlamydomonas reinhardtii	62-66
17660359-3	2007	In a parallel proteomic approach, we identified FEA1 and FEA2 as the major proteins secreted by iron-deficient Chlamydomonas reinhardtii.	Iron	96-100	uncharacterized protein	Chlamydomonas reinhardtii	57-61
17660359-4	2007	The recovery of FEA1 and FEA2 from the medium of Chlamydomonas strain CC425 cultures is strictly correlated with iron nutrition status, and the accumulation of the corresponding mRNAs parallels that of the Chlamydomonas FOX1 and FTR1 mRNAs, although the magnitude of regulation is more dramatic for the FEA genes.	Iron	113-117	uncharacterized protein	Chlamydomonas reinhardtii	25-29
17824913-1	2007	Transferrin receptor is a transmembrane protein that mediates iron transport from blood into cells.	Iron	62-66	transferrin	Homo sapiens	0-11
17761303-7	2007	Further, UV-visible spectroscopic studies show that during the reduction process the coordination environment and redox state of iron in cyt c are changed.	Iron	101-105	cytochrome c, somatic	Homo sapiens	137-142
17922749-0	2007	Effect of intravenous iron on insulin sensitivity in dialysis patients.	Iron	22-26	insulin	Homo sapiens	30-37
17768112-4	2007	Time-course of urinary hepcidin and serum transferrin concentration suggests that hepcidin production is regulated by the combination of marrow iron requirements and iron supply by transferrin.	Iron	166-170	transferrin	Homo sapiens	42-53
17660289-11	2007	Instead, enhanced growth of the pchA mutant was observed under stringent iron limitation and additional stresses.	Iron	73-77	isochorismate synthase	Pseudomonas syringae pv. tomato str. DC3000	32-36
17942062-5	2007	In contrast, the administration of exogenous erythropoietin plus iron supplements, especially iv iron, improves anemia and reduces ABT requirements, although it does not reduce mortality.	Iron	97-101	erythropoietin	Homo sapiens	45-59
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	19-23	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	92-105
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	72-76	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	92-105
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	72-76	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	92-105
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	72-76	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	92-105
17609338-7	2007	Iron loading inhibited hepcidin mRNA expression induced by IFN-gamma and M. avium, and iron chelation increased hepcidin mRNA expression.	Iron	0-4	interferon gamma	Mus musculus	59-68
17600839-9	2007	Our results demonstrate that free iron provokes the early activation of PI3K/Akt pathway, but this activation is not sufficient for protecting synaptic endings from oxidative damage.	Iron	34-38	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
17895834-2	2007	The aim of this study was to investigate the effects in the pancreas on gene expressions of metallothionein 1 (MT1), divalent metal transporter 1 (DMT1), and zinc transporter 5 (ZnT-5) and concomitant changes in iron (Fe), copper (Cu), and zinc (Zn) in serum and pancreas of Balb/c mice on days 3, 6, and 9 of CVB3 infection.	Iron	212-216	metallothionein 1	Mus musculus	92-109
17577424-0	2007	Trypanosoma brucei vacuolar protein sorting 41 (VPS41) is required for intracellular iron utilization and maintenance of normal cellular morphology.	Iron	85-89	Vps41p	Saccharomyces cerevisiae S288C	48-53
17577424-5	2007	We found a potential homologue of vacuole protein sorting 41 (VPS41), a gene that is required for high-affinity iron transport in Saccharomyces cerevisiae and cloned the full-length gene (TbVPS41).	Iron	112-116	Vps41p	Saccharomyces cerevisiae S288C	34-60
17903678-3	2007	The disorder is caused by defective iron metabolism associated with mutations in the PANK2 gene, which codes for the pantothenate kinase enzyme.	Iron	36-40	pantothenate kinase 2	Homo sapiens	85-90
17895834-2	2007	The aim of this study was to investigate the effects in the pancreas on gene expressions of metallothionein 1 (MT1), divalent metal transporter 1 (DMT1), and zinc transporter 5 (ZnT-5) and concomitant changes in iron (Fe), copper (Cu), and zinc (Zn) in serum and pancreas of Balb/c mice on days 3, 6, and 9 of CVB3 infection.	Iron	218-220	metallothionein 1	Mus musculus	92-109
17577424-5	2007	We found a potential homologue of vacuole protein sorting 41 (VPS41), a gene that is required for high-affinity iron transport in Saccharomyces cerevisiae and cloned the full-length gene (TbVPS41).	Iron	112-116	Vps41p	Saccharomyces cerevisiae S288C	62-67
17948784-3	2007	Fe(II), Co(II), Ni(II), and Hg(II) were evaluated for their impact on the dechlorination rates of PCE and TCE by FeS.	Iron	113-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
18201527-0	2007	[Role of interleukin 2 on apoptosis of lens epithelium cells in intraocular non-infective inflammation induced by iron].	Iron	114-118	interleukin-2	Oryctolagus cuniculus	9-22
18201527-1	2007	OBJECTIVE: To observe the role of Interleukin 2 (IL-2) on the apoptosis of lens epithelium cells during the intraocular non-infective inflammation induced by iron.	Iron	158-162	interleukin-2	Oryctolagus cuniculus	34-47
18201527-1	2007	OBJECTIVE: To observe the role of Interleukin 2 (IL-2) on the apoptosis of lens epithelium cells during the intraocular non-infective inflammation induced by iron.	Iron	158-162	interleukin-2	Oryctolagus cuniculus	49-53
17729391-3	2007	In these conditions, iron is deposited in hepatocytes and Kupffer cells and reactive oxygen species (ROS) produced through Fenton reaction have key role to facilitate cellular uptake of transferrin-bound iron.	Iron	21-25	transferrin	Homo sapiens	186-197
17729391-3	2007	In these conditions, iron is deposited in hepatocytes and Kupffer cells and reactive oxygen species (ROS) produced through Fenton reaction have key role to facilitate cellular uptake of transferrin-bound iron.	Iron	204-208	transferrin	Homo sapiens	186-197
17540841-0	2007	Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.	Iron	0-4	transferrin	Homo sapiens	5-16
17540841-3	2007	In humans who ingested 65 mg of iron, the increase in transferrin saturation preceded by hours the increase in urinary hepcidin excretion.	Iron	32-36	transferrin	Homo sapiens	54-65
17828809-7	2007	Treatment with erythropoietin or darbepoetin has been proven to be effective in patients with anemia, who fail to respond to intravenous iron.	Iron	137-141	erythropoietin	Homo sapiens	15-29
17711300-0	2007	Intrinsic fluorescence reports a global conformational change in the N-lobe of human serum transferrin following iron release.	Iron	113-117	transferrin	Homo sapiens	91-102
17711300-4	2007	At the putative endosomal pH of 5.6, measurement of the increase in intrinsic fluorescence upon iron release from the recombinant N-lobe yields two rate constants: 8.9 min-1 and 1.3 min-1.	Iron	96-100	CD59 molecule (CD59 blood group)	Homo sapiens	168-181
17711300-4	2007	At the putative endosomal pH of 5.6, measurement of the increase in intrinsic fluorescence upon iron release from the recombinant N-lobe yields two rate constants: 8.9 min-1 and 1.3 min-1.	Iron	96-100	CD59 molecule (CD59 blood group)	Homo sapiens	168-173
17711300-5	2007	Direct monitoring of iron release from the N-lobe at pH 5.6 (by the decrease in absorbance at 470 nm) gives a single rate constant of 9.1 min-1, definitively establishing that the faster rate constant in the fluorescent studies is due to iron release.	Iron	21-25	CD59 molecule (CD59 blood group)	Homo sapiens	138-143
17711300-5	2007	Direct monitoring of iron release from the N-lobe at pH 5.6 (by the decrease in absorbance at 470 nm) gives a single rate constant of 9.1 min-1, definitively establishing that the faster rate constant in the fluorescent studies is due to iron release.	Iron	238-242	CD59 molecule (CD59 blood group)	Homo sapiens	138-143
17540841-5	2007	Paradoxically, in previous studies in primary hepatocytes and cell lines, hepcidin response to iron or iron transferrin was not observed.	Iron	103-107	transferrin	Homo sapiens	108-119
17948784-5	2007	Relative to 0.01 M Fe(II)-added FeS batches, the dechlorination rates increased in FeS batches amended with 0.01 M of Co(II) and Hg(II), whereas the rates decreased in 0.01 M Ni(II)-added batches.	Iron	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
17666575-9	2007	In vitro data suggest that increased transferrin saturation related to iron administration may result in polymorphonuclear leukocyte dysfunction and decreased inhibition of bacterial growth.	Iron	71-75	transferrin	Homo sapiens	37-48
17650504-6	2007	In contrast, the slow phase in the kinetics of cyanide binding to the ferric CYP3A4 correlated with a shift of the heme iron spin state, which is only caused by the association of a second molecule of testosterone.	Iron	120-124	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
17452986-0	2007	The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.	Iron	78-82	melanotransferrin	Mus musculus	28-45
17452986-3	2007	Since its discovery on the plasma membrane of melanoma cells, the function of MTf has remained intriguing, particularly in relation to its role in cancer cell iron transport.	Iron	159-163	melanotransferrin	Mus musculus	78-81
17452986-4	2007	In fact, considering the crucial role of iron in many metabolic pathways, e.g., DNA synthesis, it was important to understand the function of MTf in the transport of this vital nutrient.	Iron	41-45	melanotransferrin	Mus musculus	142-145
17766221-5	2007	Iron released from the porphyrin ring leaves enterocytes as transferrin associated iron.	Iron	0-4	transferrin	Homo sapiens	60-71
17766221-5	2007	Iron released from the porphyrin ring leaves enterocytes as transferrin associated iron.	Iron	83-87	transferrin	Homo sapiens	60-71
17603005-3	2007	In this study, we report that expression of two essential components of the Fe-S machinery, the cysteine desulfurase Nfs1 and its scaffold protein partner IscU, is down-regulated at both mRNA and protein levels when murine macrophages are physiologically stimulated with IFN-gamma and LPS.	Iron	76-80	nitrogen fixation gene 1 (S. cerevisiae)	Mus musculus	117-121
17603005-3	2007	In this study, we report that expression of two essential components of the Fe-S machinery, the cysteine desulfurase Nfs1 and its scaffold protein partner IscU, is down-regulated at both mRNA and protein levels when murine macrophages are physiologically stimulated with IFN-gamma and LPS.	Iron	76-80	interferon gamma	Mus musculus	271-280
17850672-0	2007	Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-kappaB in immortalized and malignant oral keratinocytes.	Iron	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17850672-0	2007	Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-kappaB in immortalized and malignant oral keratinocytes.	Iron	27-31	nuclear factor kappa B subunit 1	Homo sapiens	83-92
17785215-3	2007	The aim of our study was to assess the association of iron stores, reflected by transferrin saturation (TSAT) and ferritin, with the dispersion of corrected QT intervals (QTc) in patients undergoing hemodialysis.	Iron	54-58	transferrin	Homo sapiens	80-91
17726138-0	2007	Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer.	Iron	23-27	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
16963052-0	2007	Non-transferrin-bound iron is associated with plasma level of soluble intercellular adhesion molecule-1 but not with in vivo low-density lipoprotein oxidation.	Iron	22-26	transferrin	Homo sapiens	4-15
16963052-1	2007	BACKGROUND: Excess body iron is associated with increased cardiovascular disease risk, possibly via non-transferrin-bound iron (NTBI)-mediated enhancement of inflammation and oxidation of low-density lipoprotein (LDL).	Iron	24-28	transferrin	Homo sapiens	104-115
16963052-1	2007	BACKGROUND: Excess body iron is associated with increased cardiovascular disease risk, possibly via non-transferrin-bound iron (NTBI)-mediated enhancement of inflammation and oxidation of low-density lipoprotein (LDL).	Iron	122-126	transferrin	Homo sapiens	104-115
17632083-8	2007	Additional experiments revealed the involvement of carbon monoxide (CO) and iron, products of HO-1-mediated heme degradation, in the cytoprotective effect of LPS.	Iron	76-80	heme oxygenase 1	Mus musculus	94-98
17726138-0	2007	Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer.	Iron	23-27	nitric oxide synthase 3	Homo sapiens	75-79
17350134-13	2007	Iron stores and TS value decreased leading to a down-regulation of hepcidin expression which increased iron absorption.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	67-75
17350134-13	2007	Iron stores and TS value decreased leading to a down-regulation of hepcidin expression which increased iron absorption.	Iron	103-107	hepcidin antimicrobial peptide	Rattus norvegicus	67-75
17628542-1	2007	Transferrin, the iron carrier protein, has been shown to be involved in oligodendroglial cell differentiation in the central nervous system but little is known about its role in the peripheral nervous system.	Iron	17-21	transferrin	Rattus norvegicus	0-11
17350134-14	2007	Hepcidin expression should be investigated in metabolic syndrome and hepatic iron overload associated with IR.	Iron	77-81	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
17438557-7	2007	MAIN OUTCOME MEASURES: Relationships between serum iron, adiposity, and serum transferrin receptor, C-reactive protein, ferritin, and iron intake analyzed by analysis of covariance and multiple linear regression.	Iron	51-55	transferrin	Homo sapiens	78-89
17438557-10	2007	Transferrin receptor, ferritin and C-reactive protein contributed independently as predictors of serum iron.	Iron	103-107	transferrin	Homo sapiens	0-11
17536071-0	2007	Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses.	Iron	15-19	insulin	Homo sapiens	94-101
17536071-2	2007	This finding might result from reduced menstrual losses secondary to oligo- or amenorrhea or from hyperinsulinism secondary to insulin resistance, because insulin favors the intestinal absorption and the tissue deposition of iron.	Iron	225-229	insulin	Homo sapiens	103-110
17536071-2	2007	This finding might result from reduced menstrual losses secondary to oligo- or amenorrhea or from hyperinsulinism secondary to insulin resistance, because insulin favors the intestinal absorption and the tissue deposition of iron.	Iron	225-229	insulin	Homo sapiens	127-134
17536071-7	2007	CONCLUSIONS: Our present results suggest that insulin resistance and hyperinsulinism, and not the reduced menstrual losses secondary to from oligo- or amenorrhea, are responsible of the increased ferritin levels and body iron stores found in overweight and obese women with PCOS.	Iron	221-225	insulin	Homo sapiens	46-53
17438557-10	2007	Transferrin receptor, ferritin and C-reactive protein contributed independently as predictors of serum iron.	Iron	103-107	C-reactive protein	Homo sapiens	35-53
17908648-1	2007	Provision of sufficient available iron is a prerequisite to ensure the bodys optimal response to recombinant human erythropoietin (epoetin).	Iron	34-38	erythropoietin	Homo sapiens	115-129
17908648-1	2007	Provision of sufficient available iron is a prerequisite to ensure the bodys optimal response to recombinant human erythropoietin (epoetin).	Iron	34-38	erythropoietin	Homo sapiens	131-138
17908648-2	2007	Functional iron deficiency (a state when iron supply is reduced to meet the demands for increased erythropoiesis) is a common cause of poor response to epoetin in dialysis patients who have normal iron status, even when they are iron-overloaded.	Iron	11-15	erythropoietin	Homo sapiens	152-159
17908648-6	2007	Recent research highlights that vitamin C can potentiate the mobilization of iron from inert tissue stores and facilitates the incorporation of iron into protoporphyrin in HD patients being treated with epoetin.	Iron	144-148	erythropoietin	Homo sapiens	203-210
17897073-0	2007	Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma.	Iron	66-70	transferrin	Homo sapiens	48-59
17897073-1	2007	Non-transferrin-bound iron (NTBI) is detectable in plasma of beta-thalassemia patients with transfusional iron overload.	Iron	22-26	transferrin	Homo sapiens	4-15
17897073-1	2007	Non-transferrin-bound iron (NTBI) is detectable in plasma of beta-thalassemia patients with transfusional iron overload.	Iron	106-110	transferrin	Homo sapiens	4-15
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	184-188	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	25-32
17567949-3	2007	In this report, we demonstrate that PrP(C) binds iron and transforms to a PrP(Sc)-like form (*PrP(Sc)) when human neuroblastoma cells are exposed to an inorganic source of redox iron.	Iron	49-53	prion protein	Homo sapiens	36-42
17567949-3	2007	In this report, we demonstrate that PrP(C) binds iron and transforms to a PrP(Sc)-like form (*PrP(Sc)) when human neuroblastoma cells are exposed to an inorganic source of redox iron.	Iron	49-53	prion protein	Homo sapiens	36-39
17567949-3	2007	In this report, we demonstrate that PrP(C) binds iron and transforms to a PrP(Sc)-like form (*PrP(Sc)) when human neuroblastoma cells are exposed to an inorganic source of redox iron.	Iron	178-182	prion protein	Homo sapiens	36-42
17567949-3	2007	In this report, we demonstrate that PrP(C) binds iron and transforms to a PrP(Sc)-like form (*PrP(Sc)) when human neuroblastoma cells are exposed to an inorganic source of redox iron.	Iron	178-182	prion protein	Homo sapiens	36-39
17567949-3	2007	In this report, we demonstrate that PrP(C) binds iron and transforms to a PrP(Sc)-like form (*PrP(Sc)) when human neuroblastoma cells are exposed to an inorganic source of redox iron.	Iron	178-182	prion protein	Homo sapiens	74-77
17567949-6	2007	Furthermore, we demonstrate increased redox-active ferrous iron levels in prion disease-affected brains, suggesting that accumulation of PrP(Sc) is modulated by the combined effect of imbalance in brain iron homeostasis and the redox-active nature of PrP(Sc).	Iron	59-63	prion protein	Homo sapiens	137-140
17659342-19	2007	AAT polymorphisms which affect iron, lipid and copper metabolism may affect early events in nervous system development, function and response to environmental exposures.	Iron	31-35	serpin family A member 1	Homo sapiens	0-3
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	137-141	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	25-32
17785948-4	2007	Iron concentration in the cell is sensed and regulated by the heme-mediated oxidization and subsequent degradation of iron regulatory protein 2 (IRP2).	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	118-143
17521857-3	2007	Abnormally low hepcidin levels promote an increase in the bioavailability of plasma iron, characterized by elevated transferrin saturation and the appearance of non transferrin bound iron.	Iron	84-88	transferrin	Homo sapiens	116-127
17521857-3	2007	Abnormally low hepcidin levels promote an increase in the bioavailability of plasma iron, characterized by elevated transferrin saturation and the appearance of non transferrin bound iron.	Iron	84-88	transferrin	Homo sapiens	165-176
17590401-7	2007	Iron loading resulted in striking increases in mRNAs for Hsp32 (heme oxygenase-1; 12-fold increase vs. controls) and metallothionein-1 and -2 (both increased approximately 6-fold).	Iron	0-4	metallothionein 1	Rattus norvegicus	117-141
17590401-9	2007	Surprisingly, although mRNA levels for the HSPs were not altered by iron, the abundance of Hsp25, Hsp70 and Hsp90 proteins was uniformly reduced in the iron-loaded livers, as were levels of NAD(P)H:quinone oxidoreductase 1, an Hsp70 client protein.	Iron	152-156	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	108-113
17785948-4	2007	Iron concentration in the cell is sensed and regulated by the heme-mediated oxidization and subsequent degradation of iron regulatory protein 2 (IRP2).	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	145-149
17590401-9	2007	Surprisingly, although mRNA levels for the HSPs were not altered by iron, the abundance of Hsp25, Hsp70 and Hsp90 proteins was uniformly reduced in the iron-loaded livers, as were levels of NAD(P)H:quinone oxidoreductase 1, an Hsp70 client protein.	Iron	152-156	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	190-222
17604281-1	2007	Iron regulatory proteins (IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	35-39
17726528-3	2007	The transferrin receptor (TfR) is involved in iron uptake by internalization of transferrin and is over-expressed in rapidly growing tumors.	Iron	46-50	transferrin	Homo sapiens	4-15
17597152-2	2007	Like transferrin of the blood plasma, lactoferrin, the iron-containing protein of human milk, saliva, tears, seminal plasma and of neutrophilic leukocytes tightly binds two ferric ions.	Iron	55-59	transferrin	Homo sapiens	5-16
17604281-1	2007	Iron regulatory proteins (IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	75-79	iron responsive element binding protein 2	Homo sapiens	35-39
17485548-8	2007	Based on the biochemical and clinical phenotype, we hypothesize that IRP2, less degraded by low heme, contributes to the repression of the erythroblasts ferritin and ALAS2, increasing mitochondrial iron.	Iron	198-202	iron responsive element binding protein 2	Homo sapiens	69-73
17485548-9	2007	Iron chelation, redistributing iron to the cytosol, might relieve IRP2 excess, improving heme synthesis and anemia.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	66-70
17485548-9	2007	Iron chelation, redistributing iron to the cytosol, might relieve IRP2 excess, improving heme synthesis and anemia.	Iron	31-35	iron responsive element binding protein 2	Homo sapiens	66-70
17721086-6	2007	Additionally, Fe-depletion up-regulates the mRNA levels of the cdk inhibitor, p21(CIP1/WAF1), but paradoxically down-regulates its protein expression.	Iron	14-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	82-86
17721086-6	2007	Additionally, Fe-depletion up-regulates the mRNA levels of the cdk inhibitor, p21(CIP1/WAF1), but paradoxically down-regulates its protein expression.	Iron	14-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-81
17721086-6	2007	Additionally, Fe-depletion up-regulates the mRNA levels of the cdk inhibitor, p21(CIP1/WAF1), but paradoxically down-regulates its protein expression.	Iron	14-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-91
17721086-8	2007	Iron-depletion also leads to proteasomal degradation of p21(CIP1/WAF1) and cyclin D1 via an ubiquitin-independent pathway.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-59
17721086-8	2007	Iron-depletion also leads to proteasomal degradation of p21(CIP1/WAF1) and cyclin D1 via an ubiquitin-independent pathway.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	60-64
17721086-8	2007	Iron-depletion also leads to proteasomal degradation of p21(CIP1/WAF1) and cyclin D1 via an ubiquitin-independent pathway.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-69
17721086-10	2007	Up-regulation of p38 mitogen-activated protein kinase (MAPK) after Fe-depletion suggests another facet of cell cycle regulation responsible for inhibition of proliferation and apoptosis induction.	Iron	67-69	mitogen-activated protein kinase 14	Homo sapiens	17-53
17596197-0	2007	Inhibition of erythroid and granulocyte-macrophage colony formation by non-transferrin-bound iron in vitro: protective effect of apotransferrin.	Iron	93-97	transferrin	Homo sapiens	75-86
17459943-1	2007	Traditionally, transferrin has been considered the primary mechanism for cellular iron delivery, despite suggestive evidence for additional iron delivery mechanisms.	Iron	82-86	transferrin	Rattus norvegicus	15-26
17893768-6	2007	A number of the HPCIH analogues show high activity at inducing Fe efflux from cells and also at preventing Fe uptake by cells from the serum Fe transport protein transferrin.	Iron	107-109	transferrin	Homo sapiens	162-173
17893768-7	2007	As a class of ligands, these chelators are more effective at reducing Fe uptake from transferrin than inducing Fe mobilisation from cells.	Iron	70-72	transferrin	Homo sapiens	85-96
17630737-0	2007	Sulfate as a synergistic anion facilitating iron binding by the bacterial transferrin FbpA: the origins and effects of anion promiscuity.	Iron	44-48	transferrin	Homo sapiens	74-85
17440755-2	2007	The best models for Ni-A and Ni-SU have hydroxo (mu-OH) bridges between Fe and Ni and a terminal sulfenate [Ni-S(=O)Cys] group, although a hydroperoxo model for Ni-A is also quite viable, whereas the best model for Ni-B has only a mu-OH bridge.	Iron	72-74	solute carrier family 5 member 5	Homo sapiens	29-33
17640859-7	2007	Sinusoidal iron deposition was associated with metabolic alterations, including body mass index, insulin resistance, and LDL cholesterol.	Iron	11-15	insulin	Homo sapiens	97-104
17995699-0	2007	Egg yolk protein and egg yolk phosvitin inhibit calcium, magnesium, and iron absorptions in rats.	Iron	72-76	casein kinase 2 beta	Rattus norvegicus	30-39
17562347-3	2007	Biochemistry of iron profile indicated a severe status of iron overload by serum iron: 194 microg/dL, serum ferritin: 6640 microg/L, transferrin saturation: 92.8%.	Iron	16-20	transferrin	Homo sapiens	133-144
17562347-3	2007	Biochemistry of iron profile indicated a severe status of iron overload by serum iron: 194 microg/dL, serum ferritin: 6640 microg/L, transferrin saturation: 92.8%.	Iron	58-62	transferrin	Homo sapiens	133-144
17562347-3	2007	Biochemistry of iron profile indicated a severe status of iron overload by serum iron: 194 microg/dL, serum ferritin: 6640 microg/L, transferrin saturation: 92.8%.	Iron	58-62	transferrin	Homo sapiens	133-144
17995699-2	2007	The effects of egg yolk protein and egg yolk phosvitin on the absorption of calcium, magnesium, and iron were investigated by in vivo studies.	Iron	100-104	casein kinase 2 beta	Rattus norvegicus	45-54
17560646-1	2007	Haem oxygenase-1 (HO-1) is an inducible enzyme that catalyses the rate-limiting step in the degradation of haem to biliverdin, carbon monoxide and iron.	Iron	147-151	heme oxygenase 1	Mus musculus	0-16
17503500-5	2007	Tissue iron levels were elevated in senescence, paralleling an increase in transferrin.	Iron	7-11	transferrin	Rattus norvegicus	75-86
17632513-4	2007	We present evidence that Mon1a is involved in trafficking of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages.	Iron	94-98	MON1 homolog A, secretory trafficking associated	Homo sapiens	25-30
17632513-4	2007	We present evidence that Mon1a is involved in trafficking of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages.	Iron	127-131	MON1 homolog A, secretory trafficking associated	Homo sapiens	25-30
17632513-6	2007	Mon1a is also important for trafficking of cell-surface and secreted molecules unrelated to iron metabolism, suggesting that it has a fundamental role in the mammalian secretory apparatus.	Iron	92-96	MON1 homolog A, secretory trafficking associated	Homo sapiens	0-5
17560646-1	2007	Haem oxygenase-1 (HO-1) is an inducible enzyme that catalyses the rate-limiting step in the degradation of haem to biliverdin, carbon monoxide and iron.	Iron	147-151	heme oxygenase 1	Mus musculus	18-22
17603935-0	2007	Tumor necrosis factor-alpha-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool.	Iron	145-149	tumor necrosis factor	Homo sapiens	0-27
17429006-0	2007	Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	147-154
17429006-0	2007	Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	155-159
17429006-0	2007	Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion.	Iron	163-167	cyclin dependent kinase inhibitor 1A	Homo sapiens	147-154
17429006-0	2007	Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion.	Iron	163-167	cyclin dependent kinase inhibitor 1A	Homo sapiens	155-159
17429006-3	2007	We observed that Fe depletion increased the mRNA of the universal cyclin-dependent kinase inhibitor, p21(CIP1/WAF1), while its protein level was not elevated.	Iron	17-19	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-104
17429006-3	2007	We observed that Fe depletion increased the mRNA of the universal cyclin-dependent kinase inhibitor, p21(CIP1/WAF1), while its protein level was not elevated.	Iron	17-19	cyclin dependent kinase inhibitor 1A	Homo sapiens	105-109
17429006-3	2007	We observed that Fe depletion increased the mRNA of the universal cyclin-dependent kinase inhibitor, p21(CIP1/WAF1), while its protein level was not elevated.	Iron	17-19	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-114
17429006-4	2007	This observation is unique to the G(1)/S arrest seen after Fe deprivation, as increased p21(CIP1/WAF1) mRNA and protein are usually found when arrest is induced by other stimuli.	Iron	59-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	88-91
17429006-4	2007	This observation is unique to the G(1)/S arrest seen after Fe deprivation, as increased p21(CIP1/WAF1) mRNA and protein are usually found when arrest is induced by other stimuli.	Iron	59-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	92-96
17429006-4	2007	This observation is unique to the G(1)/S arrest seen after Fe deprivation, as increased p21(CIP1/WAF1) mRNA and protein are usually found when arrest is induced by other stimuli.	Iron	59-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-101
17429006-5	2007	In this study, we examined the posttranscriptional regulation of p21(CIP1/WAF1) after Fe depletion and demonstrated that its down-regulation was due to 2 mechanisms: (1) inhibited translocation of p21(CIP1/WAF1) mRNA from the nucleus to cytosolic translational machinery; and (2) induction of ubiquitin-independent proteasomal degradation.	Iron	86-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-68
17429006-5	2007	In this study, we examined the posttranscriptional regulation of p21(CIP1/WAF1) after Fe depletion and demonstrated that its down-regulation was due to 2 mechanisms: (1) inhibited translocation of p21(CIP1/WAF1) mRNA from the nucleus to cytosolic translational machinery; and (2) induction of ubiquitin-independent proteasomal degradation.	Iron	86-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	69-73
17429006-5	2007	In this study, we examined the posttranscriptional regulation of p21(CIP1/WAF1) after Fe depletion and demonstrated that its down-regulation was due to 2 mechanisms: (1) inhibited translocation of p21(CIP1/WAF1) mRNA from the nucleus to cytosolic translational machinery; and (2) induction of ubiquitin-independent proteasomal degradation.	Iron	86-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-78
17429006-6	2007	Iron chelation significantly (P &lt; .01) decreased p21(CIP1/WAF1) protein half-life from 61 (+/- 4 minutes; n = 3) to 28 (+/- 9 minutes, n = 3).	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	52-55
17429006-6	2007	Iron chelation significantly (P &lt; .01) decreased p21(CIP1/WAF1) protein half-life from 61 (+/- 4 minutes; n = 3) to 28 (+/- 9 minutes, n = 3).	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-60
17429006-6	2007	Iron chelation significantly (P &lt; .01) decreased p21(CIP1/WAF1) protein half-life from 61 (+/- 4 minutes; n = 3) to 28 (+/- 9 minutes, n = 3).	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	61-65
17429006-8	2007	In Fe-replete cells, p21(CIP1/WAF1) was degraded in an ubiquitin-dependent manner, while after Fe depletion, ubiquitin-independent proteasomal degradation occurred.	Iron	3-5	cyclin dependent kinase inhibitor 1A	Homo sapiens	21-24
17429006-8	2007	In Fe-replete cells, p21(CIP1/WAF1) was degraded in an ubiquitin-dependent manner, while after Fe depletion, ubiquitin-independent proteasomal degradation occurred.	Iron	3-5	cyclin dependent kinase inhibitor 1A	Homo sapiens	25-29
17429006-8	2007	In Fe-replete cells, p21(CIP1/WAF1) was degraded in an ubiquitin-dependent manner, while after Fe depletion, ubiquitin-independent proteasomal degradation occurred.	Iron	3-5	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-34
17659826-0	2007	Iron dysregulation in Alzheimer"s disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents.	Iron	0-4	amyloid beta precursor protein	Homo sapiens	135-160
17659826-0	2007	Iron dysregulation in Alzheimer"s disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents.	Iron	70-74	amyloid beta precursor protein	Homo sapiens	135-160
17603935-3	2007	We hypothesized that TNF-induced ROS formation is due to JNK-regulated ferritin degradation and an increase in labile iron pool (LIP).	Iron	118-122	tumor necrosis factor	Homo sapiens	21-24
17603935-5	2007	TNF treatment induced ROS formation, which was reduced to the control level in cells pretreated with desferrioxamine, an iron chelator.	Iron	121-125	tumor necrosis factor	Homo sapiens	0-3
17603935-10	2007	These data suggest that TNF-induced ROS formation is mediated by JNK1, which regulates ferritin degradation and thus the level of highly reactive iron.	Iron	146-150	tumor necrosis factor	Homo sapiens	24-27
17517884-0	2007	Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network.	Iron	36-40	transferrin	Homo sapiens	51-62
17603935-10	2007	These data suggest that TNF-induced ROS formation is mediated by JNK1, which regulates ferritin degradation and thus the level of highly reactive iron.	Iron	146-150	mitogen-activated protein kinase 8	Homo sapiens	65-69
17517884-4	2007	The increase in TfR1 results in increased transferrin-mediated iron uptake and cellular accumulation of the metal.	Iron	63-67	transferrin	Homo sapiens	42-53
17555301-8	2007	These findings suggest that the mechanisms of interactions of CYP3A4 with 1-PB and testosterone involve an effector-induced transition that displaces a system of conformational equilibria in the enzyme toward the state(s) with decreased solvent accessibility of the active site so that the flux of water into the heme pocket is impeded and the high-spin state of the heme iron is stabilized.	Iron	372-376	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-68
17324120-10	2007	A possible mechanism for the activation of Cn was identified in our studies as the prevention of Fe and Zn losses from the active site of Cn, suggesting a conformation-dependent SOD1-Cn interaction.	Iron	97-99	superoxide dismutase 1	Homo sapiens	178-182
17695904-1	2007	The use of zero valent iron (Fe0) for the remediation of water contaminated with carbon disulfide (CS2), a common groundwater contaminant, has been evaluated in this study.	Iron	23-27	chorionic somatomammotropin hormone 2	Homo sapiens	99-102
17376890-7	2007	Here we show that developing erythroid cells, which are taking up vast amounts of Fe, deliver the metal directly from transferrin-containing endosomes to mitochondria (the site of heme biosynthesis), bypassing the oxygen-rich cytosol.	Iron	82-84	transferrin	Homo sapiens	118-129
17379741-3	2007	We assessed the possibility of reducing brain iron accumulation in Friedreich ataxia patients with a membrane-permeant chelator capable of shuttling chelated iron from cells to transferrin, using regimens suitable for patients with no systemic iron overload.	Iron	46-50	transferrin	Homo sapiens	177-188
17428703-2	2007	Among these proteins, it was discovered a second transferrin receptor (TfR2), that seems to play a key role in the regulation of iron homeostasis.	Iron	129-133	transferrin	Homo sapiens	49-60
17593032-0	2007	Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53.	Iron	29-33	tumor protein p53	Homo sapiens	80-83
17593032-11	2007	We hypothesise that hepcidin upregulation by p53 is part of a defence mechanism against cancer, through iron deprivation.	Iron	104-108	tumor protein p53	Homo sapiens	45-48
17852192-0	2007	Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin.	Iron	103-107	transferrin	Homo sapiens	123-134
17852192-9	2007	Circulating transferrin in blood did contain ferrous iron.	Iron	45-57	transferrin	Homo sapiens	12-23
17852192-10	2007	Binding of ferrous iron to transferrin was confirmed by estimating iron-binding capacity using ferrous ammonium sulphate.	Iron	11-23	transferrin	Homo sapiens	27-38
17852192-10	2007	Binding of ferrous iron to transferrin was confirmed by estimating iron-binding capacity using ferrous ammonium sulphate.	Iron	19-23	transferrin	Homo sapiens	27-38
17564606-1	2007	A transgenic tobacco overexpressing ferritin (P6) was recently shown to accumulate more iron than the wild type (WT), leading to a reduced availability of iron in the rhizosphere and shifts in the pseudomonad community.	Iron	88-92	ferritin-1, chloroplastic	Nicotiana tabacum	36-44
17564606-1	2007	A transgenic tobacco overexpressing ferritin (P6) was recently shown to accumulate more iron than the wild type (WT), leading to a reduced availability of iron in the rhizosphere and shifts in the pseudomonad community.	Iron	155-159	ferritin-1, chloroplastic	Nicotiana tabacum	36-44
17695904-1	2007	The use of zero valent iron (Fe0) for the remediation of water contaminated with carbon disulfide (CS2), a common groundwater contaminant, has been evaluated in this study.	Iron	29-32	chorionic somatomammotropin hormone 2	Homo sapiens	99-102
17695904-3	2007	The kinetics of CS2 removal by Fe0 was examined through both batch and column testing, and it is demonstrated that CS2 is removed rapidly from solution.	Iron	31-34	chorionic somatomammotropin hormone 2	Homo sapiens	16-19
17695904-3	2007	The kinetics of CS2 removal by Fe0 was examined through both batch and column testing, and it is demonstrated that CS2 is removed rapidly from solution.	Iron	31-34	chorionic somatomammotropin hormone 2	Homo sapiens	115-118
17722767-4	2007	RESULTS AND DISCUSSION: Results from the work indicate that the highest dioxins and PCB concentrations were recorded for iron ore sintering plants at 1.10-1.32 ng total1 TEQ/Nm3 followed by aluminium scrap melting at 0.03-0.66 ng total TEQ/Nm3.	Iron	121-125	pyruvate carboxylase	Homo sapiens	84-87
17722767-7	2007	However, iron ore sintering plants are operating at much higher production capacity, causing this process to become the major source of dioxins, PCB and HCB pollution to the atmosphere in Poland.	Iron	9-13	pyruvate carboxylase	Homo sapiens	145-148
17557118-5	2007	Through coordinate downregulation of hepcidin and upregulation of erythropoietin and ferroportin, the VHL-HIF pathway mobilizes iron to support erythrocyte production.	Iron	128-132	erythropoietin	Homo sapiens	66-80
17466466-7	2007	Our knowledge of the mechanisms of transferrin iron binding and release is based on sequence and structural data obtained for human serotransferrin and hen and duck ovotransferrins.	Iron	47-51	transferrin	Homo sapiens	35-46
17466466-7	2007	Our knowledge of the mechanisms of transferrin iron binding and release is based on sequence and structural data obtained for human serotransferrin and hen and duck ovotransferrins.	Iron	47-51	transferrin	Homo sapiens	132-147
17466466-20	2007	In snakes, the transferrin (PtrF, HtrF and GtrF) N-lobe "dilysine trigger" occurring in all other known transferrins was not found, which indicates a different mechanism of iron release.	Iron	173-177	transferrin	Homo sapiens	15-26
17466466-20	2007	In snakes, the transferrin (PtrF, HtrF and GtrF) N-lobe "dilysine trigger" occurring in all other known transferrins was not found, which indicates a different mechanism of iron release.	Iron	173-177	caveolae-associated protein 1	Python bivittatus	28-32
17438025-1	2007	The transferrin iron acquisition system of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requires the participation of two distinct proteins: TbpA and TbpB.	Iron	16-20	transferrin	Homo sapiens	4-15
17438025-1	2007	The transferrin iron acquisition system of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requires the participation of two distinct proteins: TbpA and TbpB.	Iron	16-20	transferrin	Homo sapiens	99-110
17438025-1	2007	The transferrin iron acquisition system of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requires the participation of two distinct proteins: TbpA and TbpB.	Iron	82-86	transferrin	Homo sapiens	4-15
17438025-1	2007	The transferrin iron acquisition system of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requires the participation of two distinct proteins: TbpA and TbpB.	Iron	82-86	transferrin	Homo sapiens	99-110
17438025-10	2007	We propose that TbpB is comprised of two transferrin-binding-competent lobes, both of which are critical for efficient iron uptake from human transferrin.	Iron	119-123	transferrin	Homo sapiens	41-52
17438025-10	2007	We propose that TbpB is comprised of two transferrin-binding-competent lobes, both of which are critical for efficient iron uptake from human transferrin.	Iron	119-123	transferrin	Homo sapiens	142-153
17607367-6	2007	The neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latter in an iron-dependent manner.	Iron	111-115	cathelicidin antimicrobial peptide	Homo sapiens	37-42
17560653-14	2007	Collectively, the current study suggests that supplementation of Fe during Pb treatment prevents against cytotoxicity and apoptosis induced by Pb insults, in which MAPK pathways play an important role in Pb-induced cerebral apoptosis by activating the MEK-ERK pathway that suppresses JNK signaling.	Iron	65-67	Eph receptor B1	Rattus norvegicus	256-259
17200797-1	2007	Iron regulatory proteins 1 and 2 (IRP1, IRP2) are key determinants of uptake and storage of iron by the liver, and are responsive to oxidative stress and hypoxia potentially at the level of both protein concentration and mRNA-binding activity.	Iron	92-96	iron responsive element binding protein 2	Homo sapiens	40-44
17622311-7	2007	Atherosclerotic patients (CS1 and CS2) showed increased levels of MT, MCP-1, and RANTES, reduced NK cell cytotoxicity, and altered trace element concentrations (zinc, copper, magnesium, iron).	Iron	186-190	chorionic somatomammotropin hormone 2	Homo sapiens	34-37
17495224-1	2007	Heme oxygenase (HO-1) is the rate-limiting enzyme in the catabolism of heme, which leads to the generation of biliverdin, iron, and carbon monoxide.	Iron	122-126	heme oxygenase 1	Mus musculus	16-20
17695374-2	2007	A long-standing fundamental molecular question of how ferric iron is handled in this pathway has been recently resolved by the identification of Steap3 (sixtransmembrane epithelial antigen of the prostate 3) as an endosomal ferrireductase needed for efficient utilization of transferrin-delivered iron.	Iron	61-65	STEAP3 metalloreductase	Homo sapiens	145-151
17695374-2	2007	A long-standing fundamental molecular question of how ferric iron is handled in this pathway has been recently resolved by the identification of Steap3 (sixtransmembrane epithelial antigen of the prostate 3) as an endosomal ferrireductase needed for efficient utilization of transferrin-delivered iron.	Iron	297-301	STEAP3 metalloreductase	Homo sapiens	145-151
17695374-3	2007	Further characterization of Steap3 and other Steap proteins reveals a possible greater role of Steap proteins in iron and copper metabolism.	Iron	113-117	STEAP3 metalloreductase	Homo sapiens	28-34
17452319-0	2007	Characterization of Arabidopsis thaliana SufE2 and SufE3: functions in chloroplast iron-sulfur cluster assembly and Nad synthesis.	Iron	83-87	sulfur E2	Arabidopsis thaliana	41-46
17452319-2	2007	Other SufE-like proteins, including the previously described A. thaliana CpSufE, participate in sulfur mobilization for Fe-S biosynthesis through activation of cysteine desulfurization by NifS-like proteins.	Iron	120-124	chloroplast sulfur E	Arabidopsis thaliana	73-79
17452319-6	2007	SufE2 expression was flower-specific and high in pollen; we therefore hypothesize that SufE2 has a specific function in pollen Fe-S cluster biosynthesis.	Iron	127-131	sulfur E2	Arabidopsis thaliana	0-5
17452319-6	2007	SufE2 expression was flower-specific and high in pollen; we therefore hypothesize that SufE2 has a specific function in pollen Fe-S cluster biosynthesis.	Iron	127-131	sulfur E2	Arabidopsis thaliana	87-92
17449468-6	2007	In a search for proteins containing NZF domains conserved with those of TAB2/3, we identified RBCK1, which has been shown to act as an E3 ubiquitin ligase in iron metabolism.	Iron	158-162	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	94-99
17511455-1	2007	Dysfunctional interactions of metal ions, especially Cu, Zn, and Fe, with the amyloid-beta (A beta) peptide are hypothesized to play an important role in the etiology of Alzheimer"s disease (AD).	Iron	65-67	amyloid beta precursor protein	Homo sapiens	78-90
17511455-1	2007	Dysfunctional interactions of metal ions, especially Cu, Zn, and Fe, with the amyloid-beta (A beta) peptide are hypothesized to play an important role in the etiology of Alzheimer"s disease (AD).	Iron	65-67	amyloid beta precursor protein	Homo sapiens	92-98
17391316-0	2007	Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study.	Iron	0-4	insulin	Homo sapiens	38-45
17589946-2	2007	METHODS: To identify patients with iron overload (transferrin saturation &gt; 45% in females and &gt; 50% in males and serum ferritin &gt; 1000 ng/mL) we evaluated 236 patients with CLD, including 59 with non-alcoholic steatohepatitis (NASH), 22 with alcoholic liver disease (ALD), 19 of cirrhosis due to viruses (HBV, HCV), and 136 with cryptogenic cirrhosis.	Iron	35-39	transferrin	Homo sapiens	50-61
27263618-3	2007	SMF exposure increased the plasma transferrin concentration (+25%, p&lt;0.05) and the capacity of iron saturation in transferrin (+24%, p&lt;0.05).	Iron	98-102	transferrin	Rattus norvegicus	117-128
17391316-2	2007	Iron depletion by phlebotomy has been reported to decrease insulin resistance in NAFLD in small, uncontrolled studies.	Iron	0-4	insulin	Homo sapiens	59-66
17391316-3	2007	Aims of this study were to define the relationship between ferritin and iron stores in patients with NAFLD, the effect of iron depletion on insulin resistance, and whether basal ferritin levels influence treatment outcome.	Iron	122-126	insulin	Homo sapiens	140-147
17391316-8	2007	Iron depletion produced a significantly larger decrease in insulin resistance (P=0.0016 for insulin, P=0.0042 for HOMA-R) compared with nutritional counseling alone, independent of changes in BMI, baseline HOMA-R, and the presence of the metabolic syndrome.	Iron	0-4	insulin	Homo sapiens	59-66
17391316-8	2007	Iron depletion produced a significantly larger decrease in insulin resistance (P=0.0016 for insulin, P=0.0042 for HOMA-R) compared with nutritional counseling alone, independent of changes in BMI, baseline HOMA-R, and the presence of the metabolic syndrome.	Iron	0-4	insulin	Homo sapiens	92-99
17313366-0	2007	High-affinity binding by the periplasmic iron-binding protein from Haemophilus influenzae is required for acquiring iron from transferrin.	Iron	41-45	transferrin	Homo sapiens	126-137
17313366-0	2007	High-affinity binding by the periplasmic iron-binding protein from Haemophilus influenzae is required for acquiring iron from transferrin.	Iron	116-120	transferrin	Homo sapiens	126-137
17313366-1	2007	The periplasmic iron-binding protein, FbpA (ferric-ion-binding protein A), performs an essential role in iron acquisition from transferrin in Haemophilus influenzae.	Iron	16-20	transferrin	Homo sapiens	127-138
17313366-1	2007	The periplasmic iron-binding protein, FbpA (ferric-ion-binding protein A), performs an essential role in iron acquisition from transferrin in Haemophilus influenzae.	Iron	105-109	transferrin	Homo sapiens	127-138
17313366-8	2007	These results suggest that a relatively high affinity of iron binding by FbpA is required for removal of iron from transferrin and its transport across the outer membrane.	Iron	57-61	transferrin	Homo sapiens	115-126
17313366-8	2007	These results suggest that a relatively high affinity of iron binding by FbpA is required for removal of iron from transferrin and its transport across the outer membrane.	Iron	105-109	transferrin	Homo sapiens	115-126
17511654-4	2007	APP binds copper and zinc in the extracellular domain and Abeta also binds copper, zinc and iron.	Iron	92-96	amyloid beta precursor protein	Homo sapiens	58-63
17612631-1	2007	The loop segment comprising residues 70-84 in mitochondrial cytochrome c serves to direct the polypeptide backbone to permit the functionally required heme Fe - S (Met-80) co-ordination.	Iron	156-162	cytochrome c, somatic	Homo sapiens	60-72
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	125-129	transferrin	Homo sapiens	37-48
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	125-129	transferrin	Homo sapiens	247-258
17205209-3	2007	Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1).	Iron	28-32	aconitase 2	Homo sapiens	108-131
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	125-129	transferrin	Homo sapiens	247-258
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	125-129	transferrin	Homo sapiens	247-258
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	37-48
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	247-258
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	247-258
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	247-258
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	37-48
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	247-258
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	247-258
17216400-5	2007	Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin.	Iron	186-190	transferrin	Homo sapiens	247-258
17216400-6	2007	Comparison of the recently solved crystal structure of iron-free human serum transferrin to that of human lactoferrin provides insight into these differences.	Iron	55-59	transferrin	Homo sapiens	77-88
17604457-5	2007	Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration.	Iron	87-91	RLS1	Homo sapiens	14-17
17205209-3	2007	Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1).	Iron	186-190	aconitase 2	Homo sapiens	108-131
17604457-6	2007	Iron, as a cofactor in dopamine production, plays a central role in the etiology of RLS.	Iron	0-4	RLS1	Homo sapiens	84-87
17415523-3	2007	Studies in Saccharomyces cerevisiae have demonstrated the role of the Grx5 protein in the biogenesis of iron-sulfur clusters.	Iron	104-108	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	70-74
17299088-7	2007	However, in 1-year-old th3/+ animals, Hamp1 levels rise and it is rather the increase of ferroportin (Fpn1) that sustains iron accumulation, thus revealing a fundamental role of this iron transporter in the iron overload of beta-thalassemia.	Iron	122-126	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	102-106
17299088-7	2007	However, in 1-year-old th3/+ animals, Hamp1 levels rise and it is rather the increase of ferroportin (Fpn1) that sustains iron accumulation, thus revealing a fundamental role of this iron transporter in the iron overload of beta-thalassemia.	Iron	183-187	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	102-106
17299088-7	2007	However, in 1-year-old th3/+ animals, Hamp1 levels rise and it is rather the increase of ferroportin (Fpn1) that sustains iron accumulation, thus revealing a fundamental role of this iron transporter in the iron overload of beta-thalassemia.	Iron	183-187	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	102-106
17415523-5	2007	Two S. cerevisiae monothiol glutaredoxins with the thioredoxin-like extension, Grx3 and Grx4, are modulators of the transcriptional activator Aft1, which regulates iron uptake in yeast.	Iron	164-168	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	88-92
17241724-4	2007	Adding chloride or bromide salts with Fe(0) (1% w/v) greatly enhanced TNT, RDX, and HMX degradation rates in aqueous solution.	Iron	38-43	chromosome 16 open reading frame 82	Homo sapiens	70-73
17496405-2	2007	During the first few weeks of therapy, the hemodialysis frequency was increased gradually and Erythropoietin was administered with intravenous iron therapy to keep the patient"s hemoglobin above 115 gm/L.	Iron	143-147	erythropoietin	Homo sapiens	94-108
17493025-1	2007	BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN), an extremely rare autosomal recessive disorder resulting in iron accumulation in the brain, has a diverse phenotypic expression.	Iron	129-133	pantothenate kinase 2	Homo sapiens	62-66
17377063-7	2007	Consistent with this, cellular induction of HIF-1alpha by quercetin was abolished by pretreatment with iron.	Iron	103-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
17377063-8	2007	Two iron-chelating moieties in quercetin, -OH at position 3 of the C ring and/or -OH at positions 3" and 4" of the B ring, enabled the flavonoid to inhibit HPH and subsequently induce HIF-1alpha.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	184-194
17363462-0	2007	The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation.	Iron	4-8	hepcidin antimicrobial peptide	Rattus norvegicus	28-36
17363462-1	2007	The peptide hormone hepcidin plays a central role in iron homeostasis.	Iron	53-57	hepcidin antimicrobial peptide	Rattus norvegicus	20-28
17363462-3	2007	Although it has been shown that iron plays a key pathophysiological role in cardiac diseases, including iron-overload cardiomyopathy, myocardial ischemia-reperfusion injury, and atherosclerosis, very little is known about the putative expression and the role of hepcidin in the heart.	Iron	32-36	hepcidin antimicrobial peptide	Rattus norvegicus	262-270
17654955-2	2007	Fe and Ni were used as catalyst for ASC.	Iron	0-2	PYD and CARD domain containing	Homo sapiens	36-39
17396118-5	2007	iron in anemic patients with high ferritin, low transferrin saturation, and adequate epoetin doses.	Iron	0-4	transferrin	Homo sapiens	48-59
17396118-5	2007	iron in anemic patients with high ferritin, low transferrin saturation, and adequate epoetin doses.	Iron	0-4	erythropoietin	Homo sapiens	85-92
17349663-11	2007	Fe-NTA enhanced the migration of TP53 signals into the comet tail of human leucocytes, indicating a high susceptibility of this tumour-relevant gene towards DNA damage induced by iron overload.	Iron	179-183	tumor protein p53	Homo sapiens	33-37
17613866-3	2007	Increased iron regulatory proteins could stabilize the transferrin receptor mRNA and, thereby, iron uptake.	Iron	10-14	transferrin	Homo sapiens	55-66
17613866-3	2007	Increased iron regulatory proteins could stabilize the transferrin receptor mRNA and, thereby, iron uptake.	Iron	95-99	transferrin	Homo sapiens	55-66
17722428-6	2007	Transferrin saturation (TS) &gt; or =45% was considered as iron overload.	Iron	59-63	transferrin	Homo sapiens	0-11
17383861-3	2007	Heart cells have the ability to accumulate transferrin-bound-iron via the transferrin receptor and non-transferrin-bound-iron probably via the L-type Ca2+ channel and the divalent metal transporter1.	Iron	61-65	transferrin	Rattus norvegicus	43-54
17289807-1	2007	Ferroportin disease is caused by mutation of one allele of the iron exporter ferroportin (Fpn/IREG1/Slc40a1/MTP1).	Iron	63-67	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	94-99
17289807-1	2007	Ferroportin disease is caused by mutation of one allele of the iron exporter ferroportin (Fpn/IREG1/Slc40a1/MTP1).	Iron	63-67	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	100-107
17289807-1	2007	Ferroportin disease is caused by mutation of one allele of the iron exporter ferroportin (Fpn/IREG1/Slc40a1/MTP1).	Iron	63-67	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	108-112
19086521-7	2007	Positive correlation exist between serum Iron and Hb (p &lt; 0.0001, r = 0.335), HCT (p &lt; 0.01, r = 0.1581), MCH (p &lt; 0.01, r = 0.1661) and MCHC (p &lt; 0.001, r = 0.262).	Iron	41-45	pro-melanin concentrating hormone	Homo sapiens	112-115
17375302-1	2007	The aim of the study was to evaluate the role of hypochromic erythrocytes (HYPO%) compared to "traditional" and novel markers of iron status and erythropoiesis in recognizing iron-restricted erythropoiesis (IRE) and predicting response to erythropoietin (rHuEPO) in anemic patients with myeloma and lymphoma.	Iron	175-179	erythropoietin	Homo sapiens	239-253
17146435-8	2007	Transcriptional activation of p21 by MCGA3 was mediated through the proximal region of multiple Sp1 sites regardless of p53-binding site in p21 promoter, and this effect was augmented by desferroioxamine, an iron chelating agent.	Iron	208-212	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-33
17146435-9	2007	Additional studies suggested that iron chelation-driven hypoxia by MCGA3 may function in activation of p21.	Iron	34-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	103-106
17383861-3	2007	Heart cells have the ability to accumulate transferrin-bound-iron via the transferrin receptor and non-transferrin-bound-iron probably via the L-type Ca2+ channel and the divalent metal transporter1.	Iron	61-65	transferrin	Rattus norvegicus	74-85
17383861-3	2007	Heart cells have the ability to accumulate transferrin-bound-iron via the transferrin receptor and non-transferrin-bound-iron probably via the L-type Ca2+ channel and the divalent metal transporter1.	Iron	61-65	transferrin	Rattus norvegicus	74-85
17383861-5	2007	Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart.	Iron	36-40	solute carrier family 40 member 1	Rattus norvegicus	61-74
17383861-5	2007	Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart.	Iron	36-40	solute carrier family 40 member 1	Rattus norvegicus	76-80
17383861-6	2007	We demonstrated that iron has a significant effect on expression of Fpn1 and CP, but not Heph.	Iron	21-25	solute carrier family 40 member 1	Rattus norvegicus	68-72
17383861-7	2007	Treatment of a high-iron diet induced a significant increase in Fpn1, a decrease in CP but no change in Heph mRNA and protein.	Iron	20-24	solute carrier family 40 member 1	Rattus norvegicus	64-68
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	49-53	solute carrier family 40 member 1	Rattus norvegicus	15-19
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	49-53	solute carrier family 40 member 1	Rattus norvegicus	144-148
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	159-163	solute carrier family 40 member 1	Rattus norvegicus	15-19
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	159-163	solute carrier family 40 member 1	Rattus norvegicus	144-148
17478349-0	2007	Relationship between transferrin-iron saturation, alcohol consumption, and the incidence of cirrhosis and liver cancer.	Iron	33-37	transferrin	Homo sapiens	21-32
17408467-0	2007	Iron deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21(WAF1/CIP1).	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-98
17408467-0	2007	Iron deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21(WAF1/CIP1).	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	99-103
17408467-0	2007	Iron deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21(WAF1/CIP1).	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	104-108
17408467-1	2007	Iron is required for the differentiation of HL-60 cells along the monocyte lineage in vitro, reflecting a requirement for iron in the transcriptional induction of the p21(WAF1/CIP1) gene.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	167-170
17408467-1	2007	Iron is required for the differentiation of HL-60 cells along the monocyte lineage in vitro, reflecting a requirement for iron in the transcriptional induction of the p21(WAF1/CIP1) gene.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	171-175
17408467-1	2007	Iron is required for the differentiation of HL-60 cells along the monocyte lineage in vitro, reflecting a requirement for iron in the transcriptional induction of the p21(WAF1/CIP1) gene.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	176-180
17408467-1	2007	Iron is required for the differentiation of HL-60 cells along the monocyte lineage in vitro, reflecting a requirement for iron in the transcriptional induction of the p21(WAF1/CIP1) gene.	Iron	122-126	cyclin dependent kinase inhibitor 1A	Homo sapiens	167-170
17408467-1	2007	Iron is required for the differentiation of HL-60 cells along the monocyte lineage in vitro, reflecting a requirement for iron in the transcriptional induction of the p21(WAF1/CIP1) gene.	Iron	122-126	cyclin dependent kinase inhibitor 1A	Homo sapiens	171-175
17408467-1	2007	Iron is required for the differentiation of HL-60 cells along the monocyte lineage in vitro, reflecting a requirement for iron in the transcriptional induction of the p21(WAF1/CIP1) gene.	Iron	122-126	cyclin dependent kinase inhibitor 1A	Homo sapiens	176-180
17408467-7	2007	Iron deprivation blocked p21 induction as judged by real-time polymerase chain reaction assays.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	25-28
17408467-8	2007	In addition, both iron deprivation and p21 antisense blocked CD34(+) cell differentiation.	Iron	18-22	CD34 molecule	Homo sapiens	61-65
17504117-5	2007	The mechanisms of the effects of IL-4 include impaired antimicrobial activity due to reduced TNF-alpha-mediated apoptosis of infected cells, reduced activity of iNOS, increased availability of iron to intracellular Mtb, and increased proliferation of antigen-specific FOXP-3+ regulatory T cells.	Iron	193-197	interleukin 4	Homo sapiens	33-37
17478349-2	2007	We examined the relation between baseline serum transferrin-iron saturation (TS) and the incidence of hospitalizations or deaths related to cirrhosis and liver cancer as well as the influence of alcohol consumption on this relationship.	Iron	60-64	transferrin	Homo sapiens	48-59
17449578-8	2007	Serotonin transporter levels in most brain regions and open-field exploration were also normalized with iron repletion.	Iron	104-108	solute carrier family 6 member 4	Rattus norvegicus	0-21
17561842-0	2007	Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats.	Iron	55-59	solute carrier family 40 member 1	Rattus norvegicus	0-12
17561842-5	2007	Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut.	Iron	61-65	solute carrier family 40 member 1	Rattus norvegicus	0-12
17561842-5	2007	Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut.	Iron	61-65	solute carrier family 40 member 1	Rattus norvegicus	14-17
17561842-5	2007	Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut.	Iron	100-104	solute carrier family 40 member 1	Rattus norvegicus	0-12
17561842-5	2007	Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut.	Iron	100-104	solute carrier family 40 member 1	Rattus norvegicus	14-17
17561842-12	2007	These results show for the first time that FP1 and HP co-localize in the rat brain, and suggest that decreased expression of these transporters in the SN can account for the increased iron levels.	Iron	184-188	solute carrier family 40 member 1	Rattus norvegicus	43-46
17497533-5	2007	We conclude that the reductions in Fe status detected here via the IRP assay arose, in part, from effects on transferrin-mediated Fe3+ delivery to the AM.	Iron	35-37	transferrin	Rattus norvegicus	109-120
17400258-8	2007	Moreover, a mimetic of the peroxide-scavenging enzyme, glutathione peroxidase (GPx), ebselen, blocks caspase-3 activation induced by DA alone or in combination with iron.	Iron	165-169	caspase 3	Homo sapiens	101-110
17351051-0	2007	The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation.	Iron	89-93	MATE efflux family protein	Arabidopsis thaliana	4-8
17351051-3	2007	The ferric reductase defective3 (frd3) mutant of Arabidopsis (Arabidopsis thaliana) is chlorotic and exhibits constitutive expression of its iron uptake responses.	Iron	141-145	MATE efflux family protein	Arabidopsis thaliana	33-37
17351051-4	2007	Consequently, frd3 mutants overaccumulate iron; yet, paradoxically, the frd3 phenotypes are due to a reduction in the amount of iron present inside frd3 leaf cells.	Iron	42-46	MATE efflux family protein	Arabidopsis thaliana	14-18
17351051-4	2007	Consequently, frd3 mutants overaccumulate iron; yet, paradoxically, the frd3 phenotypes are due to a reduction in the amount of iron present inside frd3 leaf cells.	Iron	128-132	MATE efflux family protein	Arabidopsis thaliana	14-18
17351051-4	2007	Consequently, frd3 mutants overaccumulate iron; yet, paradoxically, the frd3 phenotypes are due to a reduction in the amount of iron present inside frd3 leaf cells.	Iron	128-132	MATE efflux family protein	Arabidopsis thaliana	72-76
17351051-4	2007	Consequently, frd3 mutants overaccumulate iron; yet, paradoxically, the frd3 phenotypes are due to a reduction in the amount of iron present inside frd3 leaf cells.	Iron	128-132	MATE efflux family protein	Arabidopsis thaliana	72-76
17351051-6	2007	We therefore hypothesized that FRD3 loads an iron chelator necessary for the correct distribution of iron throughout the plant into the xylem.	Iron	45-49	MATE efflux family protein	Arabidopsis thaliana	31-35
17351051-6	2007	We therefore hypothesized that FRD3 loads an iron chelator necessary for the correct distribution of iron throughout the plant into the xylem.	Iron	101-105	MATE efflux family protein	Arabidopsis thaliana	31-35
17351051-8	2007	Xylem exudate from frd3 plants contains significantly less citrate and iron than the exudate from wild-type plants.	Iron	71-75	MATE efflux family protein	Arabidopsis thaliana	19-23
17351051-13	2007	These results all strongly support the hypothesis that FRD3 effluxes citrate into the root vasculature, a process important for the translocation of iron to the leaves, as well as confirm previous reports suggesting that iron moves through the xylem as a ferric-citrate complex.	Iron	149-153	MATE efflux family protein	Arabidopsis thaliana	55-59
17351051-13	2007	These results all strongly support the hypothesis that FRD3 effluxes citrate into the root vasculature, a process important for the translocation of iron to the leaves, as well as confirm previous reports suggesting that iron moves through the xylem as a ferric-citrate complex.	Iron	221-225	MATE efflux family protein	Arabidopsis thaliana	55-59
17376497-0	2007	Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells.	Iron	79-83	transferrin	Homo sapiens	61-72
17376497-1	2007	Aluminum and other trivalent metals were shown to stimulate uptake of transferrin bound iron and nontransferrin bound iron in erytholeukemia and hepatoma cells.	Iron	88-92	transferrin	Homo sapiens	70-81
17376497-3	2007	Aluminum stimulated dose- and time-dependent uptake of nontransferrin bound iron and iron bound to transferrin.	Iron	76-80	transferrin	Homo sapiens	58-69
17274015-0	2007	A PM3/d specific reaction parameterization for iron atom in the hydrogen abstraction catalyzed by soybean lipoxygenase-1.	Iron	47-51	seed linoleate 13S-lipoxygenase-1	Glycine max	106-120
17274015-1	2007	This paper reports a specific reaction parameter (SRP) PM3/d model for iron that can reproduce the DFT/MM results of the hydrogen abstraction reaction from the C11 position of linoleic acid by the Soybean lipoxygenase-1 enzyme.	Iron	71-75	seed linoleate 13S-lipoxygenase-1	Glycine max	205-219
17331953-5	2007	In acutely iron-deficient rats with markedly suppressed hepatic hepcidin expression, we detected an early phase increase of serum HJV with no significant change of either HFE2 mRNA or protein levels in gastrocnemius muscle.	Iron	11-15	hepcidin antimicrobial peptide	Rattus norvegicus	64-72
17331953-7	2007	In agreement with the observations in iron-deficient rats, HJV shedding in these cell lines was down-regulated by holo-transferrin in a concentration-dependent manner.	Iron	38-42	transferrin	Rattus norvegicus	119-130
17031680-2	2007	Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals.	Iron	120-122	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	64-91
17031680-2	2007	Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals.	Iron	120-122	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	93-97
17031680-9	2007	Depletion of the body Fe stores dramatically upregulated DMT1 and MTP1 mRNA expression in the duodenum as well as moderately upregulating their expression in several other peripheral tissues.	Iron	22-24	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	66-70
17031680-11	2007	Thus, DMT1 and MTP1 may play an important role in not only maintaining Fe levels but also facilitating the accumulation of Cd in the body of mammals.	Iron	71-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-19
17521372-0	2007	Downregulation of Fes inhibits VEGF-A-induced chemotaxis and capillary-like morphogenesis by cultured endothelial cells.	Iron	18-21	vascular endothelial growth factor A	Homo sapiens	31-37
17521372-2	2007	VEGF-A-treatment induced autophosphorylation of Fes in cultured endothelial cells.	Iron	48-51	vascular endothelial growth factor A	Homo sapiens	0-6
17521372-4	2007	Downregulation of Fes attenuated these VEGF-A-induced cellular responses but LY294002 did not produce further inhibition of these responses.	Iron	18-21	vascular endothelial growth factor A	Homo sapiens	39-45
17504202-0	2007	Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress.	Iron	106-110	transferrin	Homo sapiens	88-99
17504202-3	2007	Non-transferrin bound iron (NTBI) detected in thalassemic plasma is highly toxic and chelatable.	Iron	22-26	transferrin	Homo sapiens	4-15
17466530-2	2007	At2g28160 has been named in different ways in our previous studies, namely FRU=FER-LIKE REGULATOR OF IRON UPTAKE [M. Jakoby, H.Y.	Iron	101-105	FER-like regulator of iron uptake	Arabidopsis thaliana	75-78
17466530-3	2007	Wang, W. Reidt, B. Weisshaar, P. Bauer, FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana, FEBS Lett.	Iron	83-87	FER-like regulator of iron uptake	Arabidopsis thaliana	40-43
17466530-3	2007	Wang, W. Reidt, B. Weisshaar, P. Bauer, FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana, FEBS Lett.	Iron	83-87	FER-like regulator of iron uptake	Arabidopsis thaliana	45-52
16837131-3	2007	The aims of this study were to investigate whether iron chelation, blocking of the human insulin-like growth factor-1 receptor (hIGF1R), or both could upregulate IFN-gammaR2 and enhance the anti-proliferative effect of IFN-gamma.	Iron	51-55	interferon gamma	Homo sapiens	162-171
17242398-2	2007	The products of heme catabolism by HO-1 are ferrous iron, biliverdin (subsequently converted to bilirubin), and carbon monoxide.	Iron	44-56	heme oxygenase 1	Mus musculus	35-39
17242398-4	2007	Implicit in the reports of HO-1 cytoprotection to date are its effects on the cellular handling of heme/iron.	Iron	104-108	heme oxygenase 1	Mus musculus	27-31
17331979-3	2007	One interactor was mortalin/GRP75, a homolog of the yeast ssq1 chaperone that integrates iron-sulfur clusters into imported mitochondrial proteins.	Iron	89-93	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	58-62
17331979-4	2007	Another interactor was ISD11, recently identified as a component of the eukaryotic complex Nfs1/ISCU, an essential component of iron-sulfur cluster biogenesis.	Iron	128-132	cysteine desulfurase	Saccharomyces cerevisiae S288C	91-95
17331979-4	2007	Another interactor was ISD11, recently identified as a component of the eukaryotic complex Nfs1/ISCU, an essential component of iron-sulfur cluster biogenesis.	Iron	128-132	iron-sulfur cluster assembly enzyme	Homo sapiens	96-100
17331979-10	2007	Upon ISD11 depletion by siRNA in HEK293T cells, the amount of the Nfs1/ISCU protein complex declined, as did the activity of the iron-sulfur cluster enzyme aconitase, while the cellular iron content was increased, as seen in tissues from FRDA patients.	Iron	129-133	LYR motif containing 4	Homo sapiens	5-10
17331979-12	2007	These data suggest that frataxin binds the iron-sulfur biogenesis Nfs1/ISCU complex through ISD11, that the interaction is nickel-dependent, and that multiple consequences of frataxin deficiency are duplicated by ISD11 deficiency.	Iron	43-47	iron-sulfur cluster assembly enzyme	Homo sapiens	71-75
17331979-12	2007	These data suggest that frataxin binds the iron-sulfur biogenesis Nfs1/ISCU complex through ISD11, that the interaction is nickel-dependent, and that multiple consequences of frataxin deficiency are duplicated by ISD11 deficiency.	Iron	43-47	LYR motif containing 4	Homo sapiens	92-97
16837131-9	2007	CONCLUSION: The present results indicate that IFN-gamma reinforced by iron modulation could be a promising new therapeutic approach for HCC.	Iron	70-74	interferon gamma	Homo sapiens	46-55
17962866-6	2007	Increased liver iron accumulation and modification in the levels of adipocytokinemia can have an additional effect on insulin sensitivity in chronic C hepatitis.	Iron	16-20	insulin	Homo sapiens	118-125
18596894-1	2007	We hypothesized that myelin breakdown in vulnerable late-myelinating regions releases oligodendrocyte- and myelin-associated iron that promotes amyloid beta (A beta) oligomerization, its associated toxicity, and the deposition of oligomerized A beta and iron in neuritic plaques observed in Alzheimer"s disease (AD).	Iron	125-129	amyloid beta precursor protein	Homo sapiens	152-164
18596894-1	2007	We hypothesized that myelin breakdown in vulnerable late-myelinating regions releases oligodendrocyte- and myelin-associated iron that promotes amyloid beta (A beta) oligomerization, its associated toxicity, and the deposition of oligomerized A beta and iron in neuritic plaques observed in Alzheimer"s disease (AD).	Iron	125-129	amyloid beta precursor protein	Homo sapiens	158-164
18596894-1	2007	We hypothesized that myelin breakdown in vulnerable late-myelinating regions releases oligodendrocyte- and myelin-associated iron that promotes amyloid beta (A beta) oligomerization, its associated toxicity, and the deposition of oligomerized A beta and iron in neuritic plaques observed in Alzheimer"s disease (AD).	Iron	254-258	amyloid beta precursor protein	Homo sapiens	158-164
18596894-4	2007	Furthermore, the strikingly lower ability of this imaging ligand to bind A beta in animal models is consistent with the much lower levels of myelin and associated iron levels in rodents when compared with humans.	Iron	163-167	amyloid beta precursor protein	Homo sapiens	73-79
17204543-0	2007	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling.	Iron	0-4	interleukin 6	Homo sapiens	76-80
17204543-0	2007	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling.	Iron	0-4	vascular endothelial growth factor A	Homo sapiens	85-89
17204543-0	2007	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling.	Iron	0-4	mitogen-activated protein kinase 14	Homo sapiens	125-128
17204543-0	2007	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling.	Iron	0-4	mitogen-activated protein kinase 1	Homo sapiens	130-133
17204543-0	2007	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling.	Iron	0-4	mitogen-activated protein kinase 8	Homo sapiens	139-142
17204543-0	2007	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling.	Iron	0-4	mitogen-activated protein kinase 1	Homo sapiens	143-147
17204543-6	2007	We hypothesized that 1) fetal human intestinal epithelial cells acutely produce increased IL-6, TNF-alpha, VEGF, and HGF during iron chelation and 2) the MAPK pathway mediates these effects.	Iron	128-132	mitogen-activated protein kinase 1	Homo sapiens	154-158
17280489-4	2007	We demonstrated for the first time in vivo that the presence of catalytically active iron, deposition of myeloperoxidase, and induction of the oxidative stress in the lung-injury models were accompanied by (a) downregulation of VE-cadherin, (b) upregulation and polarization of ICAM-1 and the PLC integrins, and (c) nuclear translocation and interaction of thioredoxin, Ref-1, and NF-kappaB and complex structural changes in EC and PLC at the sites of their contacts.	Iron	85-89	thioredoxin 1	Rattus norvegicus	357-368
16927172-8	2007	In parallel, TNF-alpha and SOD expressions were increased in infarcted regions of iron-treated mice as compared to controls, whereas myocardial iNOS expression was significantly lower in iron-treated mice.	Iron	82-86	tumor necrosis factor	Mus musculus	13-22
17511610-3	2007	It is demonstrated that canine lactoferrin resembles the human homolog in some physicochemical properties, i.e. molecular weight, carbohydrate presence, and conditions of protein-iron complex dissociation.	Iron	179-183	lactotransferrin	Canis lupus familiaris	31-42
16927172-8	2007	In parallel, TNF-alpha and SOD expressions were increased in infarcted regions of iron-treated mice as compared to controls, whereas myocardial iNOS expression was significantly lower in iron-treated mice.	Iron	187-191	nitric oxide synthase 2, inducible	Mus musculus	144-148
16927172-9	2007	Although, iron challenge increased radical formation and TNF-alpha expression in vivo, this did not result in myocardial damage which may be linked to the parallel induction of SOD.	Iron	10-14	tumor necrosis factor	Mus musculus	57-66
16927172-10	2007	Importantly, iron treatment inhibited iNOS expression.	Iron	13-17	nitric oxide synthase 2, inducible	Mus musculus	38-42
16927172-11	2007	Since, an increased nitric oxide (NO) formation has been linked to cardiac damage after acute myocardial infarction, iron may exert short time cardio-protective effects after induction of ischemia/reperfusion via decreasing iNOS formation.	Iron	117-121	nitric oxide synthase 2, inducible	Mus musculus	224-228
17324148-13	2007	We suggest that EPObeta and iron treatment of anaemia promotes significant changes in serum PON1 activity and concentration and has a beneficial effect on oxidative stress in predialysis patients with chronic renal disease.	Iron	28-32	paraoxonase 1	Homo sapiens	92-96
17267016-1	2007	A two-step process for the removal of dinitrotoluene from water is presented: zero-valent iron reduction is coupled with peroxidase-catalyzed polymerization of the resulting diaminotoluenes (DAT).	Iron	90-94	peroxidase	Glycine max	121-131
17495413-8	2007	The in vitro model of I/R showed that lipid peroxidation is a trigger of the injury, and superoxide and iron ion participate in TJ opening and decrease in P-gp function.	Iron	104-108	ATP binding cassette subfamily B member 1	Homo sapiens	155-159
17883102-1	2007	Transferrin, the major iron binding protein in human plasma transports iron to various tissues.	Iron	23-27	transferrin	Homo sapiens	0-11
17379103-3	2007	In contrast, the erythropoietic response in individuals with congenital hemolytic anemia, in whom erythropoiesis is chronically raised up to sixfold over basal levels [2], is affected (and limited) by serum iron levels and by transferrin saturation [3].	Iron	207-211	transferrin	Homo sapiens	226-237
17252006-0	2007	Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study.	Iron	24-28	erythropoietin	Homo sapiens	89-96
17252006-4	2007	Higher serum ferritin and transferrin saturation in the iron group indicated that iron availability accounted for the Hb response difference.	Iron	56-60	transferrin	Homo sapiens	26-37
17883102-1	2007	Transferrin, the major iron binding protein in human plasma transports iron to various tissues.	Iron	71-75	transferrin	Homo sapiens	0-11
17252006-6	2007	In conclusion, the Hb increase and response rate were significantly greater with the addition of intravenous iron to epoetin treatment in iron-replete patients and a lower dose of epoetin was required.	Iron	109-113	erythropoietin	Homo sapiens	117-124
17883102-2	2007	The first step in cellular iron uptake is binding of transferrin complex to the cell surface membrane by specific molecule known as transferrin receptors.	Iron	27-31	transferrin	Homo sapiens	53-64
17252006-6	2007	In conclusion, the Hb increase and response rate were significantly greater with the addition of intravenous iron to epoetin treatment in iron-replete patients and a lower dose of epoetin was required.	Iron	138-142	erythropoietin	Homo sapiens	117-124
17883102-2	2007	The first step in cellular iron uptake is binding of transferrin complex to the cell surface membrane by specific molecule known as transferrin receptors.	Iron	27-31	transferrin	Homo sapiens	132-143
17237481-1	2007	BACKGROUND: The percentage of hypochromic red blood cells (RBCs) (%HYPO) has been demonstrated as the best predictor of response to iron loading in haemodialysis patients treated with recombinant human erythropoietin (rHuEPO).	Iron	132-136	erythropoietin	Homo sapiens	202-216
17283054-2	2007	Nfs1 can also provide the sulfur atoms of the iron-sulfur (Fe/S) clusters generated by the mitochondrial and cytosolic Fe/S cluster assembly machineries, termed ISC and CIA, respectively.	Iron	46-50	cysteine desulfurase	Saccharomyces cerevisiae S288C	0-4
17283054-2	2007	Nfs1 can also provide the sulfur atoms of the iron-sulfur (Fe/S) clusters generated by the mitochondrial and cytosolic Fe/S cluster assembly machineries, termed ISC and CIA, respectively.	Iron	59-61	cysteine desulfurase	Saccharomyces cerevisiae S288C	0-4
17206511-3	2007	Iron status can be monitored by different parameters such as ferritin, transferrin saturation, percentage of hypochromic red blood cells, and/or the reticulocyte hemoglobin content, but an increased erythropoietic response to iron supplementation is the most widely accepted reference standard of iron-deficient erythropoiesis.	Iron	0-4	transferrin	Homo sapiens	71-82
17244611-5	2007	Under the same physiologically relevant conditions, IscA efficiently recruits iron and transfers the iron for the iron-sulfur cluster assembly in a proposed scaffold IscU.	Iron	101-105	iron-sulfur cluster assembly enzyme	Homo sapiens	166-170
17324237-2	2007	We showed that high external pH led to increased expression of four iron uptake genes (LeIRT1, LeIRT2, LeFRO1, LeNRAMP1) regardless of the nitrogen sources.	Iron	68-72	root-specific metal transporter	Solanum lycopersicum	111-119
17324237-7	2007	The enhanced expression of LeFRO1, LeIRT1 and LeNRAMP1 under the culture condition with high pH or on agar media with NO(3) (-) as the sole N source might be a consequence of reduced iron availability in the solution or agar medium at high pH.	Iron	183-187	root-specific metal transporter	Solanum lycopersicum	46-54
17244611-5	2007	Under the same physiologically relevant conditions, IscA efficiently recruits iron and transfers the iron for the iron-sulfur cluster assembly in a proposed scaffold IscU.	Iron	101-105	iron-sulfur cluster assembly enzyme	Homo sapiens	166-170
17315920-1	2007	HO-(TPA)FeV=O (TPA = tris(2-pyridylmethyl)amine) has been proposed in the literature as the key high-valent iron-oxo intermediate involved in alkane hydroxylation.	Iron	108-112	plasminogen activator, tissue type	Homo sapiens	4-7
17315920-1	2007	HO-(TPA)FeV=O (TPA = tris(2-pyridylmethyl)amine) has been proposed in the literature as the key high-valent iron-oxo intermediate involved in alkane hydroxylation.	Iron	108-112	plasminogen activator, tissue type	Homo sapiens	15-18
17465256-4	2007	RESULTS: Patients with methylation in p16(INK4a) consumed significantly less folate (p = 0.01), vitamin A (p = 0.01), vitamin B1 (p = 0.007), potassium (p = 0.03) and iron (p = 0.02) than controls.	Iron	167-171	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-41
17376863-0	2007	MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.	Iron	15-19	CDGSH iron sulfur domain 1	Mus musculus	0-8
17376863-8	2007	Cardiac mitochondria isolated from mitoNEET-null mice demonstrate a reduced oxidative capacity, suggesting that mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates.	Iron	139-143	CDGSH iron sulfur domain 1	Mus musculus	35-43
17197702-4	2007	This complex is formed spontaneously through NO-mediated extraction of iron from ferritin and transferrin, in a reaction that requires only glutathione.	Iron	71-75	transferrin	Homo sapiens	94-105
17327678-0	2007	Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin.	Iron	49-53	transferrin	Homo sapiens	106-117
17327678-1	2007	Iron uptake by humans depends on the ability of the serum protein transferrin (Tf) to bind iron as Fe(3+) with high affinity but reversibly.	Iron	0-4	transferrin	Homo sapiens	66-77
17327678-1	2007	Iron uptake by humans depends on the ability of the serum protein transferrin (Tf) to bind iron as Fe(3+) with high affinity but reversibly.	Iron	0-4	transferrin	Homo sapiens	79-81
17327678-1	2007	Iron uptake by humans depends on the ability of the serum protein transferrin (Tf) to bind iron as Fe(3+) with high affinity but reversibly.	Iron	91-95	transferrin	Homo sapiens	66-77
17327678-1	2007	Iron uptake by humans depends on the ability of the serum protein transferrin (Tf) to bind iron as Fe(3+) with high affinity but reversibly.	Iron	91-95	transferrin	Homo sapiens	79-81
17327678-3	2007	The protonation of a hydrogen-bonded pair of lysines, Lys206 and Lys296, adjacent to the N-lobe iron site of Tf has been proposed to create a repulsive interaction that stimulates domain opening and iron release.	Iron	96-100	transferrin	Homo sapiens	109-111
17327678-3	2007	The protonation of a hydrogen-bonded pair of lysines, Lys206 and Lys296, adjacent to the N-lobe iron site of Tf has been proposed to create a repulsive interaction that stimulates domain opening and iron release.	Iron	199-203	transferrin	Homo sapiens	109-111
17202145-1	2007	Transferrin receptor 2 (TfR2) is a homolog of transferrin receptor 1 (TfR1), the receptor responsible for the uptake of iron-loaded transferrin (holo-Tf) into cells.	Iron	120-124	transferrin	Homo sapiens	46-57
17444278-3	2007	Accumulating evidence suggests that activation of cytokine cascade and the associated acute-phase response, as it often occurs in patients with CKD, divert iron from erythropoiesis to storage sites within the reticuloendothelial system leading to functional iron deficiency and subsequently to anemia or resistance to erythropoietin.	Iron	156-160	erythropoietin	Homo sapiens	318-332
17465256-4	2007	RESULTS: Patients with methylation in p16(INK4a) consumed significantly less folate (p = 0.01), vitamin A (p = 0.01), vitamin B1 (p = 0.007), potassium (p = 0.03) and iron (p = 0.02) than controls.	Iron	167-171	cyclin dependent kinase inhibitor 2A	Homo sapiens	42-47
17341272-7	2007	Iron deficiency anaemia was characterised by significantly higher EPO levels compared with other types of anaemia and normal haemoglobin, B12 and/or folate deficiency.	Iron	0-4	erythropoietin	Homo sapiens	66-69
17210254-4	2007	As a result the sulfur atom was oriented toward the iron atom of the active site of 15-LO.	Iron	52-56	arachidonate 15-lipoxygenase	Homo sapiens	84-89
17514624-0	2007	The effect of serum albumin level on iron-induced oxidative stress in chronic renal failure patients.	Iron	37-41	albumin	Homo sapiens	20-27
17453917-0	2007	Molecular chaperones HscA/Ssq1 and HscB/Jac1 and their roles in iron-sulfur protein maturation.	Iron	64-68	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	26-30
17364964-4	2007	Our data demonstrate that quercetin depletes intracellular calcein-chelatable iron and that supplying additional iron from extracellular or intracellular pools abrogates the induction of HIF-1alpha by quercetin.	Iron	113-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-197
17077321-1	2007	Ferroportin (Fpn) (IREG1, SLC40A1, MTP1) is an iron transporter, and mutations in Fpn result in a genetically dominant form of iron overload disease.	Iron	47-51	solute carrier family 40 member 1	Rattus norvegicus	26-33
17514624-3	2007	Therefore, we wanted to investigate the relation between the severity of iron-induced acute oxidative stress and serum albumin level in CRF patients.	Iron	73-77	albumin	Homo sapiens	119-126
17514624-12	2007	The severity of iron-induced acute oxidative stress was more prominent in patients with a low serum albumin level.	Iron	16-20	albumin	Homo sapiens	100-107
17514624-15	2007	CONCLUSION: This study demonstrated a negative interaction between iron-induced acute oxidative stress and serum albumin level in CRF patients.	Iron	67-71	albumin	Homo sapiens	113-120
17514624-16	2007	Because CRF patients with low serum albumin level are at greater risk for iron-induced acute oxidative stress, new strategies are necessary in this population.	Iron	74-78	albumin	Homo sapiens	36-43
17210593-7	2007	An ANCOVA analysis showed that 52% of the observed variability in epoetin dosage at completion of the stabilization phase could be accounted for by diabetes as the primary cause of kidney disease, angiotensin-converting enzyme (ACE) inhibitor/angiotensin receptor blocker (ARB) use, proteinuria, transferrin saturation, age, pre-treatment haemoglobin, geographical region, serum iron and body mass index (BMI).	Iron	379-383	erythropoietin	Homo sapiens	66-73
17182845-1	2007	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe(2)Tf).	Iron	105-109	transferrin	Homo sapiens	48-59
16504472-5	2007	In an idealized (iron tube) model, the VPO introduced a zero in the transfer function at the frequency of the nasal resonance.	Iron	17-21	peroxidasin	Homo sapiens	39-42
17316146-1	2007	STUDY OBJECTIVE: To compare non-transferrin-bound iron and markers of oxidative stress after single intravenous doses of iron dextran, sodium ferric gluconate, and iron sucrose.	Iron	50-54	transferrin	Homo sapiens	32-43
17486951-2	2007	Effective treatment of iron-deficiency anemia is critical for patients but can be challenging for nurses and fellow staff members because proper management requires a balance between erythropoietin-stimulating agents and intravenous iron therapy.	Iron	23-27	erythropoietin	Homo sapiens	183-197
17682669-1	2007	UNLABELLED: The aim of this study was to compare the diagnostic accuracy of two methods of transferrin determination in iron-deficiency anemia (IDA): immunological and chemical based on the total iron-binding capacity (TIBC).	Iron	120-124	transferrin	Homo sapiens	91-102
17682669-10	2007	The good points of immunological methods of transferrin determination (direct, simplicity, higher precision, un-dependent on iron binding, higher sensitivity) should be taken into account for the introduction of this method for routine laboratory diagnostics instead of chemical methods based on total iron-binding capacity.	Iron	125-129	transferrin	Homo sapiens	44-55
17682669-10	2007	The good points of immunological methods of transferrin determination (direct, simplicity, higher precision, un-dependent on iron binding, higher sensitivity) should be taken into account for the introduction of this method for routine laboratory diagnostics instead of chemical methods based on total iron-binding capacity.	Iron	302-306	transferrin	Homo sapiens	44-55
17237895-1	2007	Body iron stores should be assessed regularly and accurately during erythropoietin (r-HuEPO) replacement therapy.	Iron	5-9	erythropoietin	Homo sapiens	68-82
17175555-7	2007	This resembles the reported pattern of ferritin gene regulation by iron, suggesting that phosphine toxicity may be related to an increase in the level of free iron.	Iron	67-71	Ferritin	Caenorhabditis elegans	39-47
17175555-7	2007	This resembles the reported pattern of ferritin gene regulation by iron, suggesting that phosphine toxicity may be related to an increase in the level of free iron.	Iron	159-163	Ferritin	Caenorhabditis elegans	39-47
17316146-12	2007	CONCLUSION: Iron sucrose and sodium ferric gluconate were associated with greater non-transferrin-bound iron appearance compared with iron dextran.	Iron	104-108	transferrin	Homo sapiens	86-97
17316146-14	2007	The relationship between non-transferrin-bound iron from intravenous iron and oxidative stress warrants further exploration.	Iron	47-51	transferrin	Homo sapiens	29-40
17316146-14	2007	The relationship between non-transferrin-bound iron from intravenous iron and oxidative stress warrants further exploration.	Iron	69-73	transferrin	Homo sapiens	29-40
17316146-8	2007	Non-transferrin-bound iron values were significantly higher 30 minutes after administration of sodium ferric gluconate and iron sucrose compared with iron dextran (mean +/- SEM 10.1 +/- 2.2, 3.8 +/- 0.8, and 0.23 +/-0.1 microM, respectively, p&lt;0.001 for sodium ferric gluconate vs iron dextran, p = 0.002 for iron sucrose vs iron dextran).	Iron	22-26	transferrin	Homo sapiens	4-15
17316146-9	2007	A significant positive correlation was noted between transferrin saturation and the presence of non-transferrin-bound iron for sodium ferric gluconate and iron sucrose (r2 = 0.37 and 0.45, respectively, p&lt;0.001) but not for iron dextran (r2 = 0.09).	Iron	118-122	transferrin	Homo sapiens	53-64
17316146-9	2007	A significant positive correlation was noted between transferrin saturation and the presence of non-transferrin-bound iron for sodium ferric gluconate and iron sucrose (r2 = 0.37 and 0.45, respectively, p&lt;0.001) but not for iron dextran (r2 = 0.09).	Iron	118-122	transferrin	Homo sapiens	100-111
17172471-6	2007	Iron causes ERK1/2 phosphorylation that is attenuated by DN-PI3K, prevented by DNp21ras, but unaffected by DNTAK1.	Iron	0-4	mitogen-activated protein kinase 3	Homo sapiens	12-18
17239470-0	2007	Inhibition of transferrin iron release increases in vitro drug carrier efficacy.	Iron	26-30	transferrin	Homo sapiens	14-25
17239470-3	2007	We have developed a mathematical model of the Tf/TfR trafficking cycle and have identified the Tf iron release rate as a previously unreported factor governing the degree of Tf cellular association.	Iron	98-102	transferrin	Homo sapiens	46-48
17239470-3	2007	We have developed a mathematical model of the Tf/TfR trafficking cycle and have identified the Tf iron release rate as a previously unreported factor governing the degree of Tf cellular association.	Iron	98-102	transferrin	Homo sapiens	49-51
17239470-3	2007	We have developed a mathematical model of the Tf/TfR trafficking cycle and have identified the Tf iron release rate as a previously unreported factor governing the degree of Tf cellular association.	Iron	98-102	transferrin	Homo sapiens	49-51
17239470-4	2007	The release of iron from Tf is inhibited by replacing the synergistic carbonate anion with oxalate.	Iron	15-19	transferrin	Homo sapiens	25-27
17239470-9	2007	Thus, we show that inhibition of Tf iron release improves the efficacy of Tf as a drug carrier through increased association with cells expressing TfR.	Iron	36-40	transferrin	Homo sapiens	33-35
17239470-9	2007	Thus, we show that inhibition of Tf iron release improves the efficacy of Tf as a drug carrier through increased association with cells expressing TfR.	Iron	36-40	transferrin	Homo sapiens	74-76
17172471-4	2007	IKK activation induced by iron is abrogated by overexpression of a dominant negative mutant (DN) for transforming growth factor beta-activated kinase-1 (TAK1), NF-kappaB-inducing kinase, or phosphatidylinositol 3-kinase (PI3K) and by treatment with the mitogen-activated protein kinase (MAPK) kinase-1 (MEK1) inhibitor.	Iron	26-30	mitogen-activated protein kinase 3	Homo sapiens	287-291
17172471-8	2007	Iron increases interactions of TAK1 and PI3K with p21ras as demonstrated by co-immunoprecipitation and co-localization of these proteins with caveolin-1 as shown by immunofluorescent microscopy.	Iron	0-4	caveolin 1	Homo sapiens	142-152
17288615-5	2007	Among the up-regulated apoptotic genes was pirin (3.1-fold, p &lt; 0.002), an iron-binding nuclear protein and transcription cofactor.	Iron	78-82	pirin	Homo sapiens	43-48
17373738-0	2007	Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human.	Iron	38-42	transferrin	Rattus norvegicus	61-72
17373738-0	2007	Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human.	Iron	38-42	transferrin	Rattus norvegicus	77-88
17373738-0	2007	Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human.	Iron	128-132	transferrin	Rattus norvegicus	61-72
17373738-0	2007	Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human.	Iron	128-132	transferrin	Rattus norvegicus	77-88
17373738-1	2007	AIM: To elucidate the sequential transfer of iron amongst ferritin, transferrin and transferrin receptor under various iron status conditions.	Iron	45-49	transferrin	Homo sapiens	68-79
17373738-1	2007	AIM: To elucidate the sequential transfer of iron amongst ferritin, transferrin and transferrin receptor under various iron status conditions.	Iron	45-49	transferrin	Homo sapiens	84-95
17373738-1	2007	AIM: To elucidate the sequential transfer of iron amongst ferritin, transferrin and transferrin receptor under various iron status conditions.	Iron	119-123	transferrin	Homo sapiens	84-95
17373738-7	2007	The concentration of mucosal ferritin was significantly higher in the iron excess group compared to control, iron deficient groups (731.5 +/- 191.96 vs 308.3 +/- 123.36, 731.5 +/- 191.96 vs 256.0 +/- 1.19, P &lt; 0.005), while that of luminal transferrin which was significantly higher than the mucosal did not differ among the groups (10.9 +/- 7.6 vs 0.87 +/- 0.79, 11.1 +/- 10.3 vs 0.80 +/- 1.20, 6.8 +/- 4.7 vs 0.61 +/- 0.63, P &lt; 0.001).	Iron	70-74	transferrin	Homo sapiens	243-254
17373738-9	2007	This was demonstrated to occur through the initial binding of iron to luminal transferrin then to absorptive cell surface transferrin receptors.	Iron	62-66	transferrin	Homo sapiens	78-89
17373738-9	2007	This was demonstrated to occur through the initial binding of iron to luminal transferrin then to absorptive cell surface transferrin receptors.	Iron	62-66	transferrin	Homo sapiens	122-133
17373738-11	2007	CONCLUSION: It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin.	Iron	56-60	transferrin	Homo sapiens	124-135
17373738-11	2007	CONCLUSION: It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin.	Iron	56-60	transferrin	Homo sapiens	137-148
17373738-11	2007	CONCLUSION: It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin.	Iron	56-60	transferrin	Homo sapiens	137-148
17095038-2	2007	These reduction reactions may play a role in DBP fate in iron water mains and potentially could be exploited to remove DBPs from drinking water or wastewater in a packed-bed configuration.	Iron	57-61	D-box binding PAR bZIP transcription factor	Homo sapiens	45-48
17121833-3	2007	Mammalian cells utilize transferrin-dependent mechanisms to acquire iron via transferrin receptors 1 and 2 (TfR1 and TfR2) by receptor-mediated endocytosis.	Iron	68-72	transferrin	Homo sapiens	24-35
17121833-5	2007	The expression of this surface GAPDH is regulated by the availability of iron in the medium.	Iron	73-77	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	31-36
17121859-5	2007	The properties that permit GLRX2, and not other glutaredoxins, to form an iron-sulfur-containing dimer are likely due to the proline-to-serine substitution in the active site motif, allowing the main chain more flexibility in this area and providing polar interaction with the stabilizing glutathione.	Iron	74-78	glutaredoxin 2	Homo sapiens	27-32
17087999-1	2007	The hbd (hemoglobin deficit) mutation affects iron trafficking in murine reticulocytes.	Iron	46-50	exocyst complex component 6	Mus musculus	4-7
17095038-3	2007	Oxidants (i.e., dissolved oxygen (DO) and chlorine) present in the water, however, may decrease the DBP degradation rate by competing for reactive sites and rapidly aging or corroding the iron surface.	Iron	188-192	D-box binding PAR bZIP transcription factor	Homo sapiens	100-103
17097691-0	2007	Involvement of protein kinase Cdelta in iron chelator-induced IL-8 production in human intestinal epithelial cells.	Iron	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
17206377-4	2007	AIM OF THE STUDY: To undertake a pilot study to investigate the effect of carrying the G277S transferrin mutation on non-haem iron absorption from a meal in young menstruating women compared to wild-type controls.	Iron	126-130	transferrin	Homo sapiens	93-104
17091493-1	2007	Transferrin receptors (Tfrc) are membrane bound glycoproteins which function to mediate cellular uptake of iron from transferrin.	Iron	107-111	transferrin	Rattus norvegicus	117-128
17229905-0	2007	Renal iron metabolism: transferrin iron delivery and the role of iron regulatory proteins.	Iron	6-10	transferrin	Homo sapiens	23-34
16876448-5	2007	It is concluded that (*)NO response induced by CIO represents a molecular mechanism affording protection against iron toxicity, which is related to both the activation of the ERK/NF-kappaB pathway involving inducible NOS expression and ferritin upregulation, changes that may be interrelated.	Iron	113-117	mitogen-activated protein kinase 1	Homo sapiens	175-178
17279810-5	2007	The latter reaction may proceed via an iron(IV) intermediate, which can oxidize the normally noncoordinating, inert [B(ArF)4]- counteranion [ArF = 3,5-(CF3)2Ph].	Iron	39-43	ADP ribosylation factor 4	Homo sapiens	119-124
17279810-5	2007	The latter reaction may proceed via an iron(IV) intermediate, which can oxidize the normally noncoordinating, inert [B(ArF)4]- counteranion [ArF = 3,5-(CF3)2Ph].	Iron	39-43	ADP ribosylation factor 3	Homo sapiens	141-148
17209550-0	2007	Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase.	Iron	108-112	myeloperoxidase	Homo sapiens	133-148
17209550-8	2007	Our results are consistent with two halide binding sites that could be populated by two halides in which both display distinct effects on the MPO heme iron microenvironment.	Iron	151-155	myeloperoxidase	Homo sapiens	142-145
17460390-0	2007	Angiotensin II-induced regulation of the expression and localization of iron metabolism-related genes in the rat kidney.	Iron	72-76	angiotensinogen	Rattus norvegicus	0-14
17460390-2	2007	We have previously shown that the administration of angiotensin II alters iron homeostasis in the rat kidney, which may in turn aggravate angiotensin II-induced renal damage.	Iron	74-78	angiotensinogen	Rattus norvegicus	52-66
17460390-2	2007	We have previously shown that the administration of angiotensin II alters iron homeostasis in the rat kidney, which may in turn aggravate angiotensin II-induced renal damage.	Iron	74-78	angiotensinogen	Rattus norvegicus	138-152
17460390-6	2007	Staining of serial sections revealed that some, but not all, of the renal tubular cells positive for these genes contained iron deposits in the kidney of angiotensin II-infused animals.	Iron	123-127	angiotensinogen	Rattus norvegicus	154-168
17460390-7	2007	Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan.	Iron	82-86	solute carrier family 40 member 1	Rattus norvegicus	121-124
17460390-7	2007	Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan.	Iron	82-86	hepcidin antimicrobial peptide	Rattus norvegicus	130-138
17460390-7	2007	Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan.	Iron	82-86	angiotensinogen	Rattus norvegicus	222-236
17338998-5	2007	METHODS AND RESULTS: IRON-HF study is a multicenter, investigator initiated, randomized, double-blind, placebo controlled trial that will enroll anemic HF patients with relatively preserved renal function, low transferrin saturation, low iron levels, and low to moderately elevated ferritin levels.	Iron	21-25	transferrin	Homo sapiens	210-221
17256058-1	2007	Heme oxygenase-1 (HO-1, encoded by HMOX1) dampens inflammatory reactions via the catabolism of heme into CO, Fe, and biliverdin.	Iron	109-111	heme oxygenase 1	Mus musculus	0-22
17256058-1	2007	Heme oxygenase-1 (HO-1, encoded by HMOX1) dampens inflammatory reactions via the catabolism of heme into CO, Fe, and biliverdin.	Iron	109-111	heme oxygenase 1	Mus musculus	35-40
17003376-9	2007	Based on these observations, we suggest that oral iron therapy is not the therapy of choice for patients with EPP and that the PPIX-liver transferrin pathway plays a role in the orchestration of iron distribution between peripheral iron stores, the spleen, and the bone marrow.	Iron	195-199	transferrin	Homo sapiens	138-149
17003376-9	2007	Based on these observations, we suggest that oral iron therapy is not the therapy of choice for patients with EPP and that the PPIX-liver transferrin pathway plays a role in the orchestration of iron distribution between peripheral iron stores, the spleen, and the bone marrow.	Iron	195-199	transferrin	Homo sapiens	138-149
17097691-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating ERK1/2 and p38 kinase pathways.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
17097691-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating ERK1/2 and p38 kinase pathways.	Iron	33-37	mitogen-activated protein kinase 3	Homo sapiens	205-211
17198418-3	2007	It is showed that, in the early stages of the catalytic cycle, a neutral mu-H adduct is formed; monoelectron reduction and subsequent protonation can give rise to a diprotonated neutral species (a-muH-SH), which is characterized by a mu-H group, a protonated sulfur atom, and a CO group bridging the two iron centers, in agreement with experimental IR data indicating the formation of a long-lived mu7-CO species.	Iron	304-308	familial progressive hyperpigmentation 1	Homo sapiens	73-77
17097691-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating ERK1/2 and p38 kinase pathways.	Iron	33-37	mitogen-activated protein kinase 1	Homo sapiens	216-219
17097691-8	2007	Collectively, these results suggest that PKCdelta plays a pivotal role in signaling pathways leading to iron chelator-induced IL-8 production in human IECs.	Iron	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16935854-8	2007	Likewise, expression of genes participating in duodenal Fe uptake (Dcytb, DMT1) and transfer (ferroportin) were increased in TfR2 mutant mice.	Iron	56-58	cytochrome b reductase 1	Mus musculus	67-72
17068284-9	2007	Atherosclerotic plaques from C57Bl/6 ApoE-/- Hp 2-2 mice were associated with increased iron (P=0.008), lipid peroxidation (4-hydroxynonenal and ceroid) and macrophage accumulation (P=0.03) as compared with plaques from C57Bl/6 ApoE-/- Hp 1-1 mice.	Iron	88-92	apolipoprotein E	Mus musculus	37-41
17115894-0	2007	How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?	Iron	9-13	glutaredoxin 2	Homo sapiens	73-87
17115894-3	2007	The authors have demonstrated that the iron-sulfur cluster is complexed by the two N-terminal active site thiols of two Grx2 monomers and two molecules of glutathione that are bound noncovalently to the proteins and in equilibrium with glutathione in solution.	Iron	39-43	glutaredoxin 2	Homo sapiens	120-124
17266850-7	2007	Transferrin was negatively correlated with "free" iron (r=-0.519; p=0.000).	Iron	50-54	transferrin	Homo sapiens	0-11
17266850-11	2007	"Free" iron does not explain the presence of edema but, as with severe hypoalbuminemia, the concurrence of a low transferrin level and a high saturation index may contribute to the etiology of edema.	Iron	7-11	transferrin	Homo sapiens	113-124
17953080-5	2007	The cause of RLS is probably mainly genetic with a dysfunction of iron and dopamine metabolism accentuated by peripheral factors (neuropathy, radiculopathy, and temperature).	Iron	66-70	RLS1	Homo sapiens	13-16
18198398-8	2007	A significant positive correlation (r=0.981, p=0.000) between the differences in serum iron levels and differences in transferrin saturation percentages and a significant negative correlation (r=-0.916, p&lt;0.001) between the differences in serum iron levels and differences in TIBC was found, as well.	Iron	87-91	transferrin	Homo sapiens	118-129
16968894-7	2007	We suggest that the transferrin bound to the monoclonal IgG molecule has a prolonged half-life in the circulation, leading to high transferrin concentrations, and that the increased serum iron values prevent the onset of anemia.	Iron	188-192	transferrin	Homo sapiens	20-31
16968894-8	2007	The antitransferrin activity of monoclonal antibody should be added to the list of situations accounting for elevated serum iron with elevated transferrin saturation.	Iron	124-128	transferrin	Homo sapiens	8-19
17878720-6	2007	The highest quartile of transferrin iron saturation showed a decreased risk of ischemic stroke in men (OR 0.44; 95% CI 0.22-0.87; p for trend 0.028), but not in women.	Iron	36-40	transferrin	Homo sapiens	24-35
16963107-10	2007	An explanation for the arsenic diel cycles observed is the light induced photooxidation of As(III) and the elimination of As(V) due to its adsorption onto Fe precipitates during the daytime.	Iron	155-157	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	122-127
17126400-8	2007	Hepatic hepcidin transcript levels correlated significantly with serum iron concentrations (r=0.54, p&lt;0.05) and with the percent saturation of transferrin (r=0.63, p&lt;0.05).	Iron	71-75	hepcidin	Ictalurus punctatus	8-16
17579565-7	2007	Apparently, the serum proteins ferritin, transferrin and TfR are more appropriate tools for the diagnosis of iron status in newborns.	Iron	109-113	transferrin	Homo sapiens	41-52
17617032-1	2007	BACKGROUND: Iron-induced oxidative stress may be implicated in the alteration of the lipoprotein-associated antioxidant enzymes paraoxonase 1 (PON1) and platelet-activating factor acetylhydrolase (PAF-AH), leading to atherosclerosis-related vascular complication in patients with beta-thalassemia hemoglobin E (beta-thal/Hb E).	Iron	12-16	paraoxonase 1	Homo sapiens	128-141
17617032-1	2007	BACKGROUND: Iron-induced oxidative stress may be implicated in the alteration of the lipoprotein-associated antioxidant enzymes paraoxonase 1 (PON1) and platelet-activating factor acetylhydrolase (PAF-AH), leading to atherosclerosis-related vascular complication in patients with beta-thalassemia hemoglobin E (beta-thal/Hb E).	Iron	12-16	paraoxonase 1	Homo sapiens	143-147
17126400-9	2007	Similar to mammalian hepcidins, channel catfish hepcidin is an iron-responsive gene and may also play important roles in innate host defense to infection and in iron homeostasis.	Iron	63-67	hepcidin	Ictalurus punctatus	21-29
17945001-6	2007	These latter alterations may contribute to the inappropriate iron deficiency signal sensed by the duodenal enterocytes of these mice, and the subsequent upregulation of the genes encoding the ferrireductase Dcytb and several iron transporters or facilitators of iron transport in the duodenum.	Iron	61-65	cytochrome b reductase 1	Mus musculus	207-212
17786642-0	2007	Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice.	Iron	6-10	heme oxygenase 1	Mus musculus	53-69
17786642-2	2007	We examined the effect of rapid induction of hepatic HO-1 on serum iron level.	Iron	67-71	heme oxygenase 1	Mus musculus	53-57
17786642-3	2007	Serum iron was approximately doubled within 6 h when HO-1 was induced by phenobarbital treatment of selenium-deficient mice.	Iron	6-10	heme oxygenase 1	Mus musculus	53-57
17786642-8	2007	Further, they link HO-1 induction with a rise in serum iron, suggesting that the iron resulting from catabolism of heme by HO-1 is released by the liver.	Iron	55-59	heme oxygenase 1	Mus musculus	19-23
17786642-8	2007	Further, they link HO-1 induction with a rise in serum iron, suggesting that the iron resulting from catabolism of heme by HO-1 is released by the liver.	Iron	55-59	heme oxygenase 1	Mus musculus	123-127
17786642-8	2007	Further, they link HO-1 induction with a rise in serum iron, suggesting that the iron resulting from catabolism of heme by HO-1 is released by the liver.	Iron	81-85	heme oxygenase 1	Mus musculus	19-23
17786642-8	2007	Further, they link HO-1 induction with a rise in serum iron, suggesting that the iron resulting from catabolism of heme by HO-1 is released by the liver.	Iron	81-85	heme oxygenase 1	Mus musculus	123-127
17241879-2	2007	In response to interleukin 6 (IL-6), hepatocytes produce hepcidin that decreases iron release/transfer from enterocytes and macrophages and causes hypoferremia.	Iron	81-85	interleukin 6	Mus musculus	15-28
17241879-2	2007	In response to interleukin 6 (IL-6), hepatocytes produce hepcidin that decreases iron release/transfer from enterocytes and macrophages and causes hypoferremia.	Iron	81-85	interleukin 6	Mus musculus	30-34
17640392-1	2007	BACKGROUND: Iron uptake via endocytosis of iron-transferrin-transferrin receptor complexes is a rate-limiting step for cell growth, viability and proliferation in tumor cells as well as non-transformed cells such as activated lymphocytes.	Iron	12-16	transferrin	Homo sapiens	48-59
17640392-1	2007	BACKGROUND: Iron uptake via endocytosis of iron-transferrin-transferrin receptor complexes is a rate-limiting step for cell growth, viability and proliferation in tumor cells as well as non-transformed cells such as activated lymphocytes.	Iron	12-16	transferrin	Homo sapiens	60-71
17640392-6	2007	CONCLUSION: Our study identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a new regulator of iron-transferrin uptake and serves as a proof-of-concept that targeted RNA interference screens of the signaling proteome provide a powerful and unbiased approach to discover or rank signaling pathways that regulate a particular cell function.	Iron	98-102	mechanistic target of rapamycin kinase	Homo sapiens	53-57
17640392-6	2007	CONCLUSION: Our study identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a new regulator of iron-transferrin uptake and serves as a proof-of-concept that targeted RNA interference screens of the signaling proteome provide a powerful and unbiased approach to discover or rank signaling pathways that regulate a particular cell function.	Iron	98-102	transferrin	Homo sapiens	103-114
17187402-7	2007	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis [corrected]	Iron	104-108	transforming growth factor beta 1	Homo sapiens	35-43
17187402-7	2007	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis [corrected]	Iron	123-127	transforming growth factor beta 1	Homo sapiens	35-43
18086376-4	2007	We found that macrophages lacking functional Nramp1 exhibited a significantly higher iron uptake via transferrin receptor 1 and, as a consequence of this, an increased iron release which is mediated via the iron export protein ferroportin-1.	Iron	168-172	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	227-240
18086376-2	2007	Nramp1 acts as a transporter for protons, iron, and other divalent cations, and Nramp1 functionality is associated with an enhanced activity of pro-inflammatory immune pathways, including the formation of nitric oxide (NO) via transcriptional stimulation of inducible nitric oxide synthase (iNOS) expression.	Iron	42-46	nitric oxide synthase 2, inducible	Mus musculus	258-289
18086376-4	2007	We found that macrophages lacking functional Nramp1 exhibited a significantly higher iron uptake via transferrin receptor 1 and, as a consequence of this, an increased iron release which is mediated via the iron export protein ferroportin-1.	Iron	168-172	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	227-240
18086376-2	2007	Nramp1 acts as a transporter for protons, iron, and other divalent cations, and Nramp1 functionality is associated with an enhanced activity of pro-inflammatory immune pathways, including the formation of nitric oxide (NO) via transcriptional stimulation of inducible nitric oxide synthase (iNOS) expression.	Iron	42-46	nitric oxide synthase 2, inducible	Mus musculus	291-295
18086376-6	2007	Since low intracellular iron availability enhances iNOS transcription, Nramp1 could exert its effect on NO formation and other pro-inflammatory immune pathways via modulation of iron homeostasis.	Iron	24-28	nitric oxide synthase 2, inducible	Mus musculus	51-55
18086376-6	2007	Since low intracellular iron availability enhances iNOS transcription, Nramp1 could exert its effect on NO formation and other pro-inflammatory immune pathways via modulation of iron homeostasis.	Iron	178-182	nitric oxide synthase 2, inducible	Mus musculus	51-55
17160644-2	2007	Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake.	Iron	104-108	transferrin	Homo sapiens	116-127
17127642-3	2007	Meanwhile, the competition between Mn and iron for iron transporters, such as transferrin and DMT-1, to the brain has also been implicated in the welding-fume exposure.	Iron	42-46	INHCAP	Macaca fascicularis	78-89
16944229-6	2007	Similarly, both the general reaction pattern and detailed kinetics and thermodynamics data point to a regiospecific addition reaction of P(OMe)(3) directed at the heme iron within multiply charged ions from cyt c.	Iron	168-172	cytochrome c, somatic	Homo sapiens	207-212
17004073-2	2007	With iron(III) cytochrome c, CO (3) (*-) reacts with the protein moiety with rate constants of (5.1 +/- 0.6) x 10(7) M(-1) s(-1) (pH 8.4, I approximately 0.27 M) and (1.0 +/- 0.2) x 10(8) M(-1) s(-1) (pH 10, I = 0.5 M).	Iron	5-9	cytochrome c, somatic	Homo sapiens	15-27
17004073-6	2007	We propose that CO (3) (*-) oxidizes the iron center directly, and that the lower rate observed at pH 10 is due to the different charge distribution of iron(II) cytochrome c.	Iron	41-45	cytochrome c, somatic	Homo sapiens	161-173
17004073-6	2007	We propose that CO (3) (*-) oxidizes the iron center directly, and that the lower rate observed at pH 10 is due to the different charge distribution of iron(II) cytochrome c.	Iron	152-156	cytochrome c, somatic	Homo sapiens	161-173
17969640-1	2007	A kind of Fe-polysilicate polymer, poly-silicic-ferric (PSF) coagulant was prepared by co-polymerization (hydroxylation of mixture of Fe3+ and fresh polysilicic acid (PS)), in which PSF0.5, PSF1 or PSF3 denotes Si/Fe molar ratio of 0.5, 1 or 3, respectively.	Iron	10-12	GINS complex subunit 1	Homo sapiens	190-194
17227437-8	2007	However, DAT degradation rates increased three-fivefold in both cell types exposed to 50 microM DFO for 24 h. Biotinylation studies in N2A cells indicate a more dramatic loss of DAT in the membrane fraction, while OptiPrep fractionation experiments revealed an increase in lysosomal DAT with iron chelation.	Iron	292-296	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	9-12
17227437-9	2007	Inhibition of protein kinase C activation with staurosporin prevented the effect of iron chelation on DAT function, suggesting that in vitro iron chelation affects DAT primarily through the effects on trafficking rather than on synthesis.	Iron	84-88	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	102-105
17227437-9	2007	Inhibition of protein kinase C activation with staurosporin prevented the effect of iron chelation on DAT function, suggesting that in vitro iron chelation affects DAT primarily through the effects on trafficking rather than on synthesis.	Iron	84-88	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	164-167
17127361-6	2007	There has been reported some differences in the Fe binding and oxidation properties between mtF and cytosolic H-ferritin suggesting that mtF functions differently as an Fe storage protein within the mitochondria and perhaps has other function(s) in Fe homeostasis as well.	Iron	48-50	ferritin mitochondrial	Mus musculus	92-95
17127361-6	2007	There has been reported some differences in the Fe binding and oxidation properties between mtF and cytosolic H-ferritin suggesting that mtF functions differently as an Fe storage protein within the mitochondria and perhaps has other function(s) in Fe homeostasis as well.	Iron	48-50	ferritin mitochondrial	Mus musculus	137-140
17127361-6	2007	There has been reported some differences in the Fe binding and oxidation properties between mtF and cytosolic H-ferritin suggesting that mtF functions differently as an Fe storage protein within the mitochondria and perhaps has other function(s) in Fe homeostasis as well.	Iron	169-171	ferritin mitochondrial	Mus musculus	137-140
17160644-2	2007	Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake.	Iron	154-158	transferrin	Homo sapiens	116-127
17227437-0	2007	Down-regulation of dopamine transporter by iron chelation in vitro is mediated by altered trafficking, not synthesis.	Iron	43-47	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	19-39
17227437-9	2007	Inhibition of protein kinase C activation with staurosporin prevented the effect of iron chelation on DAT function, suggesting that in vitro iron chelation affects DAT primarily through the effects on trafficking rather than on synthesis.	Iron	141-145	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	102-105
17227437-9	2007	Inhibition of protein kinase C activation with staurosporin prevented the effect of iron chelation on DAT function, suggesting that in vitro iron chelation affects DAT primarily through the effects on trafficking rather than on synthesis.	Iron	141-145	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	164-167
17353176-0	2007	Reticulocyte hemoglobin equivalent: an indicator of reduced iron availability in chronic kidney diseases during erythropoietin therapy.	Iron	60-64	erythropoietin	Homo sapiens	112-126
18928154-6	2007	After adjustment for gender, age, hemodialysis duration, ferritin, phosphorus, waist and total fat percentages, multivariate regression analysis was performed and the association with HOMA-IR was still strong only for serum levels of iron and TNF-alpha.	Iron	234-238	tumor necrosis factor	Homo sapiens	243-252
18928154-0	2007	The effect of nutritional status, body composition, inflammation and serum iron on the developement of insulin resistance among patients on long-term hemodialysis.	Iron	75-79	insulin	Homo sapiens	103-110
18928154-1	2007	We investigated the effect of body composition, nutrition, inflammation and iron status on insulin resistance in patients with long-term hemodialysis.	Iron	76-80	insulin	Homo sapiens	91-98
17873309-9	2007	According to our results the inflammatory activity represented by high levels of IL-6 and CRP are involved in the pathogenesis of ACD, probably due to the action of inflammation on iron metabolism, but not in ARC.	Iron	181-185	interleukin 6	Homo sapiens	81-85
17873309-9	2007	According to our results the inflammatory activity represented by high levels of IL-6 and CRP are involved in the pathogenesis of ACD, probably due to the action of inflammation on iron metabolism, but not in ARC.	Iron	181-185	C-reactive protein	Homo sapiens	90-93
18928154-10	2007	The present study demonstrated that adipokine TNF-alpha and serum iron participated as independent predictors in the pathogenesis of insulin resistance on long-term hemodialysis patients.	Iron	66-70	insulin	Homo sapiens	133-140
17890877-0	2007	Effect of iron loading on peripheral blood lymphocyte subsets and on circulating cytokine levels in iron-depleted hemodialysis patients receiving erythropoietin.	Iron	10-14	erythropoietin	Homo sapiens	146-160
17125964-5	2007	Using an ELISA assay, an increased amount of H. somnus whole cells and culture supernatant bound to bovine transferrin when the organism was grown in iron-restricted media.	Iron	150-154	serotransferrin	Bos taurus	107-118
17125964-7	2007	Transferrin, but not lactoferrin, supported growth of H. somnus on iron-depleted agar based media using a disk assay.	Iron	67-71	serotransferrin	Bos taurus	0-11
17125964-8	2007	Therefore, lactoferrin increased virulence by an undetermined mechanism whereas transferrin increased virulence of H. somnus by binding to iron-regulated outer-membrane proteins (IROMPs) and providing iron to the pathogen.	Iron	139-143	serotransferrin	Bos taurus	80-91
17433645-3	2007	Transcriptional analysis of C. albicans treated with PGE2 indicated differential expression of genes involved in alternative carbon source catabolism, and showed repression of genes encoding components of both the translational machinery and the homolog of Saccharomyces cerevisiae Mac1 regulon needed for iron uptake.	Iron	306-310	Mac1p	Saccharomyces cerevisiae S288C	282-286
17516455-7	2007	Iron substitution is justified in people with iron deficiency related RLS (ferritin concentration lower than 50 microg/L).	Iron	0-4	RLS1	Homo sapiens	70-73
17566122-6	2007	Autopsy studies and intravenous iron treatment further link brain iron insufficiency to RLS.	Iron	32-36	RLS1	Homo sapiens	88-91
17566122-8	2007	In this article the data are reviewed that support the following postulates combining dopaminergic and iron causes of RLS: (1) All conditions that compromise iron availability will increase the risk of RLS leading to a higher than expected prevalence of RLS in these conditions.	Iron	103-107	RLS1	Homo sapiens	118-121
17566122-8	2007	In this article the data are reviewed that support the following postulates combining dopaminergic and iron causes of RLS: (1) All conditions that compromise iron availability will increase the risk of RLS leading to a higher than expected prevalence of RLS in these conditions.	Iron	158-162	RLS1	Homo sapiens	118-121
17566122-9	2007	(2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron.	Iron	45-49	RLS1	Homo sapiens	23-26
17566122-9	2007	(2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron.	Iron	140-144	RLS1	Homo sapiens	23-26
17566122-9	2007	(2) Some patients with RLS have marginal CNS iron status that can become insufficient when deprived of normal access to adequate peripheral iron or may be insufficient even with normal access to adequate peripheral iron.	Iron	140-144	RLS1	Homo sapiens	23-26
17566122-10	2007	(3) The change or reduced CNS iron status produces RLS symptoms largely through its effects on the dopaminergic system and the corollary to 3.	Iron	30-34	RLS1	Homo sapiens	51-54
17566122-12	2007	Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder.	Iron	13-17	RLS1	Homo sapiens	27-30
17890877-1	2007	BACKGROUND/AIMS: High doses of iron are recommended intravenously in iron-depleted hemodialysis (HD) patients receiving recombinant erythropoietin (EPO).	Iron	31-35	erythropoietin	Homo sapiens	132-146
17890877-1	2007	BACKGROUND/AIMS: High doses of iron are recommended intravenously in iron-depleted hemodialysis (HD) patients receiving recombinant erythropoietin (EPO).	Iron	31-35	erythropoietin	Homo sapiens	148-151
17890877-4	2007	The aim of this study was to evaluate the effect of iron load on peripheral blood lymphocytes subsets and on circulating cytokine levels in HD iron depleted patients, treated with EPO.	Iron	52-56	erythropoietin	Homo sapiens	180-183
17890877-13	2007	After iron load there was no significant change to the major lymphocyte subsets examined but a significant increase of the percentage and number of T lymphocytes with positive natural killer receptors (NKR+ T) cells was observed, 5.1 +/- 3.7% to 6.3 +/- 3.46%, p &lt; 0.05, and 76.4 +/- 40 to 101.5 +/- 48 cells/microl, p &lt; 0.005, respectively.	Iron	6-10	killer cell lectin like receptor B1	Homo sapiens	202-205
17890877-14	2007	CONCLUSION: Iron load in iron-deficient EPO-treated HD patients did not produce any changes in major lymphocyte subsets in peripheral blood, but it resulted in a significant increase of NKR+ T cells, a subpopulation important for local immune responses.	Iron	12-16	erythropoietin	Homo sapiens	40-43
17890877-14	2007	CONCLUSION: Iron load in iron-deficient EPO-treated HD patients did not produce any changes in major lymphocyte subsets in peripheral blood, but it resulted in a significant increase of NKR+ T cells, a subpopulation important for local immune responses.	Iron	12-16	killer cell lectin like receptor B1	Homo sapiens	186-189
17890877-14	2007	CONCLUSION: Iron load in iron-deficient EPO-treated HD patients did not produce any changes in major lymphocyte subsets in peripheral blood, but it resulted in a significant increase of NKR+ T cells, a subpopulation important for local immune responses.	Iron	25-29	erythropoietin	Homo sapiens	40-43
17890877-15	2007	Iron load for a relatively short period improved anemia of HD patients and influenced the levels of the circulating IL-2, which may regulate factors affecting the survival of patients.	Iron	0-4	interleukin 2	Homo sapiens	116-120
17384814-0	2007	Role of iron in the nitric oxide-mediated fungicidal mechanism of IFN-gamma-activated murine macrophages against Paracoccidioides brasiliensis conidia.	Iron	8-12	interferon gamma	Mus musculus	66-75
17571974-0	2007	Iron stimulates urokinase plasminogen activator expression and activates NF-kappa B in human prostate cancer cells.	Iron	0-4	nuclear factor kappa B subunit 1	Homo sapiens	73-83
17571974-5	2007	Treatment of PC-3 cells with iron in the form of ferric nitrilotriacetate (FeNTA) in the absence of added transferrin resulted in a dose-dependent increase in cellular ferritin content in both the presence and absence of neutralizing antibody to the transferrin receptor.	Iron	29-33	transferrin	Homo sapiens	250-261
17571974-6	2007	Cellular uptake of iron resulted in stimulation of intracellular ROI production, and increases in uPA mRNA, antigen, and activity.	Iron	19-23	plasminogen activator, urokinase	Homo sapiens	98-101
17571974-8	2007	Finally, we observed nuclear translocation, and therefore activation of NF-kappaB in response to iron exposure.	Iron	97-101	nuclear factor kappa B subunit 1	Homo sapiens	72-81
17571974-9	2007	We conclude that iron enters PC-3 cells via a non-transferrin dependent pathway and increases uPA expression.	Iron	17-21	transferrin	Homo sapiens	50-61
17571974-9	2007	We conclude that iron enters PC-3 cells via a non-transferrin dependent pathway and increases uPA expression.	Iron	17-21	plasminogen activator, urokinase	Homo sapiens	94-97
17571974-10	2007	Our data indicate that one mechanism by which iron may stimulate uPA production is through the generation of intracellular ROI and activation of NF-kappaB-mediated signaling pathways.	Iron	46-50	plasminogen activator, urokinase	Homo sapiens	65-68
17571974-10	2007	Our data indicate that one mechanism by which iron may stimulate uPA production is through the generation of intracellular ROI and activation of NF-kappaB-mediated signaling pathways.	Iron	46-50	nuclear factor kappa B subunit 1	Homo sapiens	145-154
18409349-1	2007	Transferrin (Tf) plays a crucial role in iron transport in the human body.	Iron	41-45	transferrin	Homo sapiens	0-11
18409349-1	2007	Transferrin (Tf) plays a crucial role in iron transport in the human body.	Iron	41-45	transferrin	Homo sapiens	13-15
18409349-4	2007	The aim of this study was the assessment of the associations between changes of glycosylation of transferrin and selected blood cell count and iron metabolism parameters in ESRD patients treated by maintenance hemodialysis (mHD) with long lasting anaemia despite treatment by rHuEPO.	Iron	143-147	transferrin	Homo sapiens	97-108
18333366-0	2007	IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism.	Iron	54-58	interleukin 6	Homo sapiens	0-4
17384814-11	2007	These results suggest that the NO-mediated fungicidal mechanism exerted by IFN-gamma-activated macrophages against P. brasiliensis conidia, is dependent of an iron interaction.	Iron	159-163	interferon gamma	Mus musculus	75-84
18333366-0	2007	IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism.	Iron	54-58	signal transducer and activator of transcription 3	Homo sapiens	7-13
17169158-2	2006	The stress protein heme oxygenase-1 (HO-1) catalyzes heme degradation producing biliverdin, iron and CO.	Iron	92-96	heme oxygenase 1	Mus musculus	19-35
20020877-10	2007	Other important molecular pathways include iron binding to transferrin in the bloodstream for cellular delivery through the plasma membrane transferrin receptor (TfR1).	Iron	43-47	transferrin	Homo sapiens	59-70
20020877-10	2007	Other important molecular pathways include iron binding to transferrin in the bloodstream for cellular delivery through the plasma membrane transferrin receptor (TfR1).	Iron	43-47	transferrin	Homo sapiens	140-151
20020877-11	2007	In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism.	Iron	16-20	iron responsive element binding protein 2	Homo sapiens	59-63
20020877-11	2007	In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism.	Iron	114-118	iron responsive element binding protein 2	Homo sapiens	59-63
17305125-0	2007	Application of iron-coated sand and manganese-coated sand on the treatment of both As(III) and As(V).	Iron	15-19	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	95-100
17305125-1	2007	In this study, manganese-coated sand (MCS) and iron-coated sand (ICS) were applied in the oxidation of As(III) and adsorption of As(V), respectively.	Iron	47-51	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	129-134
16937407-3	2006	In developing animal-component free media for CHO and other mammalian cell lines, the iron-transporter function of serum or human/bovine transferrin is usually replaced by certain organic or inorganic chelators capable of delivering iron for cell respiration and metabolism, but few of them are sufficiently effective.	Iron	86-90	serotransferrin	Bos taurus	137-148
17178876-4	2006	The iron chelators desferrioxamine and cobalt chloride, which induce hypoxia-inducible factor (HIF)-mediated transcription, also increased CCR7 expression; transfection of a dominant-negative version of the HIF regulatory subunit, HIF-1alpha, into MCF-7 cells abolished CCR7 induction by endothelins, indicating that increased expression is due to HIF-1 stabilization.	Iron	4-8	C-C motif chemokine receptor 7	Homo sapiens	139-143
17178876-4	2006	The iron chelators desferrioxamine and cobalt chloride, which induce hypoxia-inducible factor (HIF)-mediated transcription, also increased CCR7 expression; transfection of a dominant-negative version of the HIF regulatory subunit, HIF-1alpha, into MCF-7 cells abolished CCR7 induction by endothelins, indicating that increased expression is due to HIF-1 stabilization.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-241
17178876-4	2006	The iron chelators desferrioxamine and cobalt chloride, which induce hypoxia-inducible factor (HIF)-mediated transcription, also increased CCR7 expression; transfection of a dominant-negative version of the HIF regulatory subunit, HIF-1alpha, into MCF-7 cells abolished CCR7 induction by endothelins, indicating that increased expression is due to HIF-1 stabilization.	Iron	4-8	C-C motif chemokine receptor 7	Homo sapiens	270-274
17178876-4	2006	The iron chelators desferrioxamine and cobalt chloride, which induce hypoxia-inducible factor (HIF)-mediated transcription, also increased CCR7 expression; transfection of a dominant-negative version of the HIF regulatory subunit, HIF-1alpha, into MCF-7 cells abolished CCR7 induction by endothelins, indicating that increased expression is due to HIF-1 stabilization.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-236
17802774-2	2007	With the help of general blood analysis and biochemistry studies there was detected a disturbance of iron metabolism, declaring itself in decreasing iron serum indices, serum ferritin saturation factor and increase of general iron combined ability levels, latent combined ability and levels of serum erythropoietin.	Iron	101-105	erythropoietin	Homo sapiens	300-314
17236123-2	2007	Thus, the cellular influx of transferrin-bound iron from the endosomal compartment into the cytasol is compromised.	Iron	47-51	transferrin	Homo sapiens	29-40
17236123-10	2007	The phenotypic expression of genetic hemochromatosis may depend on the activity of the erythron to use transferrin-bound-iron for heme synthesis.	Iron	121-125	transferrin	Homo sapiens	103-114
17165810-4	2006	The present work illustrates the use of ICPMS isotope dilution analysis for the quantification of transferrin isoforms once saturated with iron and separated by anion exchange chromatography (Mono Q 5/50) using a mobile phase consisting of a gradient of ammonium acetate (0-250 mM) in 25 mM Tris-acetic acid (pH 6.5).	Iron	139-143	transferrin	Homo sapiens	98-109
16973969-0	2006	Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity.	Iron	0-4	dynein cytoplasmic 1 heavy chain 1	Mus musculus	86-89
17056012-7	2006	Model building studies on the human HIF prolyl hydroxylase 2 showed that the two phenolate oxygen atoms of gallate form a chelate with the active site Fe(2+), while the carboxyl group of gallate forms a strong ionic/hydrogen bonding interaction with Arg383, explaining why nPG, which has an esterified carboxyl group, is unable to inhibit the hydroxylase.	Iron	151-153	egl-9 family hypoxia inducible factor 1	Homo sapiens	36-60
17217102-3	2006	However, some patients showed hyporesponsiveness to erythropoietin because of inadequate iron supply to the erythroid bone marrow.	Iron	89-93	erythropoietin	Homo sapiens	52-66
17217102-5	2006	Demand for iron is also increased by the treatment for anemia with erythropoietin.	Iron	11-15	erythropoietin	Homo sapiens	67-81
17119084-0	2006	Is supplementary iron useful when preterm infants are treated with erythropoietin?	Iron	17-21	erythropoietin	Homo sapiens	67-81
17070507-3	2006	METHODS AND RESULTS: The incubation of macrophages derived from the human monocyte cell line THP-1 with iron (100 microm)/ascorbate (1000 microm) for a period of 4 h induced a strong peroxidation, as demonstrated by the elevation of malondialdehyde (220%, P &lt; 0.001).	Iron	104-108	GLI family zinc finger 2	Homo sapiens	93-98
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Iron	264-268	sterol 14-demethylase	Saccharomyces cerevisiae S288C	151-156
17109638-3	2006	Original Raji cells have previously been adapted to long-term culture in a defined medium with 5 microg/ml of iron-saturated human transferrin as a source of iron.	Iron	110-114	transferrin	Homo sapiens	131-142
17109638-3	2006	Original Raji cells have previously been adapted to long-term culture in a defined medium with 5 microg/ml of iron-saturated human transferrin as a source of iron.	Iron	158-162	transferrin	Homo sapiens	131-142
17109638-6	2006	Iron deprivation induced cell death in both Raji cells and Raji/lowFe-re cells; that is, cells pre-adapted to a near optimum source of extracellular iron (5 microg/ml of transferrin).	Iron	0-4	transferrin	Homo sapiens	170-181
17109638-6	2006	Iron deprivation induced cell death in both Raji cells and Raji/lowFe-re cells; that is, cells pre-adapted to a near optimum source of extracellular iron (5 microg/ml of transferrin).	Iron	149-153	transferrin	Homo sapiens	170-181
17257079-2	2006	Growth modification caused by FSC iron involves a diminished expression of Bcl-2 and an overexpression of p53 proto-oncogene, accompanied by an increased incidence of apoptosis.	Iron	34-38	BCL2 apoptosis regulator	Homo sapiens	75-80
17109638-8	2006	We demonstrated that cell death induction by iron deprivation in Raji cells correlates with the activation of executioner caspase-3 and the cleavage of caspase-3 substrate, poly-ADP ribose polymerase.	Iron	45-49	caspase 3	Homo sapiens	122-131
17109638-8	2006	We demonstrated that cell death induction by iron deprivation in Raji cells correlates with the activation of executioner caspase-3 and the cleavage of caspase-3 substrate, poly-ADP ribose polymerase.	Iron	45-49	caspase 3	Homo sapiens	152-161
17109638-8	2006	We demonstrated that cell death induction by iron deprivation in Raji cells correlates with the activation of executioner caspase-3 and the cleavage of caspase-3 substrate, poly-ADP ribose polymerase.	Iron	45-49	poly(ADP-ribose) polymerase 1	Homo sapiens	173-199
17109638-10	2006	Taken together, we suggest that in human Raji cells, iron deprivation induces apoptotic cell death related to caspase-3 activation.	Iron	53-57	caspase 3	Homo sapiens	110-119
17257079-2	2006	Growth modification caused by FSC iron involves a diminished expression of Bcl-2 and an overexpression of p53 proto-oncogene, accompanied by an increased incidence of apoptosis.	Iron	34-38	tumor protein p53	Homo sapiens	106-109
17168739-0	2006	Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders.	Iron	17-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-13
17116183-1	2006	AIMS: To assess insulin sensitivity and secretion in the fasting state in regularly transfused patients with beta-thalassaemia major with normal glucose response during an oral glucose tolerance test and to estimate its possible relation to iron overload.	Iron	241-245	insulin	Homo sapiens	16-23
16979622-7	2006	Iron-laden macrophages may influence HSCs through the action of TGF-beta(1) in DMN-induced liver fibrosis.	Iron	0-4	transforming growth factor, beta 1	Rattus norvegicus	64-75
17220079-7	2006	The EXAFS data indicate that adsorbed As(V) forms inner-sphere complexes with bidentate-binuclear configurations, as evidenced by an As-Fe bond distance of 3.28 +/- 0.04 A and an As-Al bond distance of 3.17 +/- 0.03 A.	Iron	136-138	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	38-43
17220079-8	2006	The two As(V) complexes were stable at different As(V) loadings, whereas the proportions were related to the aluminum and iron mineral contents in the soils.	Iron	122-126	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	8-13
17119383-2	2006	Anemia of inflammation is caused by the effects of inflammatory cytokines [predominantly interleukin-6 (IL-6)] on iron transport in enterocytes and macrophages.	Iron	114-118	interleukin 6	Homo sapiens	89-102
17287552-6	2006	RESULTS: Significantly lower levels of T lymphocytes as well as CD4+ cells was observed in the iron deficient children (P&lt;0.01 and 0.002 respectively).	Iron	95-99	CD4 molecule	Homo sapiens	64-67
17287552-8	2006	Iron supplementation improved the CD4 counts significantly.	Iron	0-4	CD4 molecule	Homo sapiens	34-37
17119383-2	2006	Anemia of inflammation is caused by the effects of inflammatory cytokines [predominantly interleukin-6 (IL-6)] on iron transport in enterocytes and macrophages.	Iron	114-118	interleukin 6	Homo sapiens	104-108
17119383-9	2006	Similarly, the difference between baseline and 2-hour serum iron level (Delta[Fe]2hr) correlated with IL-6 (P = 0.008) and CRP (P = 0.045).	Iron	60-64	interleukin 6	Homo sapiens	102-106
17119383-9	2006	Similarly, the difference between baseline and 2-hour serum iron level (Delta[Fe]2hr) correlated with IL-6 (P = 0.008) and CRP (P = 0.045).	Iron	60-64	C-reactive protein	Homo sapiens	123-126
17190448-8	2006	Sodwanone V (8) inhibited both hypoxia-induced and iron chelator (1,10-phenanthroline)-induced HIF-1 activation in T47D breast tumor cells (IC50 15 microM), and 8 was the only sodwanone that inhibited HIF-1 activation in PC-3 prostate tumor cells (IC50 15 microM).	Iron	51-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-100
17305242-6	2006	Such electrophoretic analyses showed that gel antibodies against iron-free transferrin had a high selectivity for this protein, although some crossreaction took place with iron-saturated transferrin, indicating that these artificial antibodies can easily distinguish the minute differences in the 3-D structure of the transferrins.	Iron	65-69	transferrin	Homo sapiens	75-86
17164650-1	2006	OBJECTIVES: To know the variations of serum transferrin receptor (sTfR) and its indices depending on the status of body iron and the presence of infection in children, to evaluate their usefulness for recognizing the nature of anemia in infection, and to know the role of erythropoietic activity in these conditions.	Iron	120-124	transferrin	Homo sapiens	44-55
17305242-6	2006	Such electrophoretic analyses showed that gel antibodies against iron-free transferrin had a high selectivity for this protein, although some crossreaction took place with iron-saturated transferrin, indicating that these artificial antibodies can easily distinguish the minute differences in the 3-D structure of the transferrins.	Iron	172-176	transferrin	Homo sapiens	187-198
17043664-6	2006	By contrast, in the kidneys of angiotensin II-infused rats, apoptosis occurred in tubular cells that contained deposits of iron but not lipids.	Iron	123-127	angiotensinogen	Rattus norvegicus	31-45
17305242-7	2006	Analogously, gel antibodies against iron-saturated transferrin were highly selective for this protein with some crossreaction with iron-free transferrin.	Iron	36-40	transferrin	Homo sapiens	51-62
17305242-7	2006	Analogously, gel antibodies against iron-saturated transferrin were highly selective for this protein with some crossreaction with iron-free transferrin.	Iron	36-40	transferrin	Homo sapiens	141-152
17305242-7	2006	Analogously, gel antibodies against iron-saturated transferrin were highly selective for this protein with some crossreaction with iron-free transferrin.	Iron	131-135	transferrin	Homo sapiens	51-62
17305242-7	2006	Analogously, gel antibodies against iron-saturated transferrin were highly selective for this protein with some crossreaction with iron-free transferrin.	Iron	131-135	transferrin	Homo sapiens	141-152
17305242-8	2006	The mobilities of iron-free and iron-saturated transferrin are very similar, and, therefore, capillary free zone electrophoresis cannot distinguish between these structurally related proteins.	Iron	32-36	transferrin	Homo sapiens	47-58
17305242-9	2006	However, significant differences in the mobilities of the selective gel granules can be observed depending on their interaction with iron-free or iron-saturated transferrin, i.e., the artificial gel antibodies may become powerful analytical tools.	Iron	133-137	transferrin	Homo sapiens	161-172
17305242-9	2006	However, significant differences in the mobilities of the selective gel granules can be observed depending on their interaction with iron-free or iron-saturated transferrin, i.e., the artificial gel antibodies may become powerful analytical tools.	Iron	146-150	transferrin	Homo sapiens	161-172
17178036-9	2006	CONCLUSIONS: Serum iron and transferrin levels markedly decreased in NS patients, which may be partially related to the urinary loss of transferrin.	Iron	19-23	transferrin	Homo sapiens	136-147
19412490-1	2006	Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient"s sleep, mood, daytime function, and quality of life.	Iron	68-72	RLS1	Homo sapiens	172-175
16877034-8	2006	If treatment with the Fe and metal ions was simultaneous (co-treatment), the effects of nickel ion exposure were overwhelmed, since the added Fe reversed HIF-1alpha stabilization, decreased IRP-1 activity, and increased ferritin level.	Iron	22-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
16842238-10	2006	We show that in vivo targeting of a human nucleoside diphosphate kinase (Nm23-H4), which converts ATP into GTP, to the matrix of ggc1 mutants restores normal iron regulation.	Iron	158-162	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	73-80
16877034-8	2006	If treatment with the Fe and metal ions was simultaneous (co-treatment), the effects of nickel ion exposure were overwhelmed, since the added Fe reversed HIF-1alpha stabilization, decreased IRP-1 activity, and increased ferritin level.	Iron	142-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
17082561-0	2006	Investigating iron status in microcytic anaemia: zincprotoporphyrin and soluble transferrin receptor have a role.	Iron	14-18	transferrin	Homo sapiens	80-91
16950787-7	2006	Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and deferoxamine (an iron chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation was further investigated.	Iron	130-134	protein kinase C alpha	Homo sapiens	58-80
16950787-7	2006	Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and deferoxamine (an iron chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation was further investigated.	Iron	130-134	protein kinase C alpha	Homo sapiens	192-214
16950787-7	2006	Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and deferoxamine (an iron chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation was further investigated.	Iron	130-134	NFE2 like bZIP transcription factor 2	Homo sapiens	227-231
16950787-7	2006	Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and deferoxamine (an iron chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation was further investigated.	Iron	219-223	protein kinase C alpha	Homo sapiens	58-80
16950787-7	2006	Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and deferoxamine (an iron chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation was further investigated.	Iron	219-223	NFE2 like bZIP transcription factor 2	Homo sapiens	227-231
17185172-1	2006	For studying the effects of endogenous ferritin gene expressions (NtFer1, GenBank accession number AY083924; and NtFer2, GenBank accession number AY141105) on the iron homeostasis in transgenic tobacco (Nicotiana tabacum L.) plants expressing soybean (Glycine max Merr) ferritin gene (SoyFer1, GenBank accession number M64337), the transgenic tobacco has been produced by placing soybean ferritin cDNA cassette under the control of the CaMV 35S promoter.	Iron	163-167	ferritin-1, chloroplastic	Nicotiana tabacum	39-47
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	60-64	melanotransferrin	Mus musculus	0-17
17185172-1	2006	For studying the effects of endogenous ferritin gene expressions (NtFer1, GenBank accession number AY083924; and NtFer2, GenBank accession number AY141105) on the iron homeostasis in transgenic tobacco (Nicotiana tabacum L.) plants expressing soybean (Glycine max Merr) ferritin gene (SoyFer1, GenBank accession number M64337), the transgenic tobacco has been produced by placing soybean ferritin cDNA cassette under the control of the CaMV 35S promoter.	Iron	163-167	ferritin-1, chloroplastic	Nicotiana tabacum	66-72
17185172-6	2006	These results demonstrated that exogenous ferritin expression induced increased expression of at least one of the endogenous ferritin genes in transgenic tobacco plants by enhancing the ferric chelate reductase activity and iron transport ability of the root, and improved the rate of photosynthesis.	Iron	224-228	ferritin-1, chloroplastic	Nicotiana tabacum	42-50
17185172-6	2006	These results demonstrated that exogenous ferritin expression induced increased expression of at least one of the endogenous ferritin genes in transgenic tobacco plants by enhancing the ferric chelate reductase activity and iron transport ability of the root, and improved the rate of photosynthesis.	Iron	224-228	ferritin-1, chloroplastic	Nicotiana tabacum	125-133
16848758-5	2006	EPR spectroscopy revealed that the free iron in the transfusate was rendered redox inactive by rapid binding to transferrin.	Iron	40-44	transferrin	Homo sapiens	112-123
16896902-1	2006	Transferrin, an iron-binding protein, plays an important role in the transport and delivery of circulating ferric iron to the tissues.	Iron	16-20	transferrin	Homo sapiens	0-11
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	60-64	melanotransferrin	Mus musculus	19-22
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	66-68	melanotransferrin	Mus musculus	0-17
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	66-68	melanotransferrin	Mus musculus	19-22
16704991-2	2006	It has been suggested that MTf is involved in a variety of processes such as Fe metabolism and cellular differentiation.	Iron	77-79	melanotransferrin	Mus musculus	27-30
16704991-3	2006	Considering the crucial role of Fe in many metabolic pathways, for example, DNA synthesis, it is important to understand the function of MTf.	Iron	32-34	melanotransferrin	Mus musculus	137-140
16765418-0	2006	PCDD/F and "Dioxin-like" PCB emissions from iron ore sintering plants in the UK.	Iron	44-48	pyruvate carboxylase	Homo sapiens	25-28
16904380-2	2006	Iron uptake occurs via the internalization of iron-loaded transferrin (Tf) mediated by the interaction with the TfR.	Iron	0-4	transferrin	Homo sapiens	71-73
16765418-2	2006	Results showed that the sintering of iron ore produces a characteristic WHO-12 PCB and PCDD/F congener pattern that is substantially the same for all UK sinter plants.	Iron	37-41	pyruvate carboxylase	Homo sapiens	79-82
16904380-2	2006	Iron uptake occurs via the internalization of iron-loaded transferrin (Tf) mediated by the interaction with the TfR.	Iron	46-50	transferrin	Homo sapiens	58-69
16904380-2	2006	Iron uptake occurs via the internalization of iron-loaded transferrin (Tf) mediated by the interaction with the TfR.	Iron	0-4	transferrin	Homo sapiens	58-69
16904380-2	2006	Iron uptake occurs via the internalization of iron-loaded transferrin (Tf) mediated by the interaction with the TfR.	Iron	46-50	transferrin	Homo sapiens	71-73
17019598-0	2006	Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis.	Iron	91-95	insulin	Homo sapiens	10-17
17119290-7	2006	The evidence for transferrin-dependent and independent mechanisms of brain iron uptake is presented.	Iron	75-79	transferrin	Homo sapiens	17-28
17254375-1	2006	Lactoferrin and serum transferrin, the iron-binding proteins, are widely distributed in biological fluids.	Iron	39-43	transferrin	Homo sapiens	22-33
17160963-3	2006	METHODS: An in vitro HD system was constructed to determine the dialyzability of iron from a normal saline compartment (NSC) containing 1000 mg iron of VIT 45.	Iron	144-148	vitrin	Homo sapiens	152-155
17074835-7	2006	The absence of both Grx3 and Grx4 induced a clear enrichment of G1 cells in asynchronous cultures, a slow growth phenotype, the accumulation of intracellular iron and a constitutive activation of the genes regulated by Aft1.	Iron	158-162	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	29-33
17063114-8	2006	FRAP was found to be significantly higher in patients with NAFLD as compared with healthy controls [450.3 (197.6 to 733.3) vs. 340.8 (141.6 to 697.5) mumol Fe liberated; P=0.04], even though it was similar between NAFLD and diseased controls.	Iron	156-158	mechanistic target of rapamycin kinase	Homo sapiens	0-4
17019598-5	2006	RESULTS: Normalisation of tissue iron stores resulted in an average 1.8-fold increase in the integrated area under the insulin curve during OGTT (p&lt;0.0001), but no significant change in the area under the glucose curve (10% decrease, p=0.32).	Iron	33-37	insulin	Homo sapiens	119-126
17019598-11	2006	CONCLUSIONS/INTERPRETATION: Insulin secretory capacity improves after normalisation of iron stores in subjects with hereditary haemochromatosis.	Iron	87-91	insulin	Homo sapiens	28-35
17373274-4	2006	Non-transferrin bound iron plays an important role in cellular iron excess and damage.	Iron	22-26	transferrin	Homo sapiens	4-15
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	68-72	tumor protein p53	Homo sapiens	14-17
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	167-171	tumor protein p53	Homo sapiens	14-17
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	167-171	cyclin dependent kinase inhibitor 1A	Homo sapiens	29-33
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	167-171	BCL2 apoptosis regulator	Homo sapiens	93-98
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	167-171	BCL2 associated X, apoptosis regulator	Homo sapiens	203-206
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	68-72	cyclin dependent kinase inhibitor 1A	Homo sapiens	29-33
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	68-72	BCL2 apoptosis regulator	Homo sapiens	93-98
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	242-246	tumor protein p53	Homo sapiens	14-17
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	68-72	BCL2 associated X, apoptosis regulator	Homo sapiens	203-206
16957011-10	2006	Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds.	Iron	242-246	BCL2 apoptosis regulator	Homo sapiens	93-98
17373274-4	2006	Non-transferrin bound iron plays an important role in cellular iron excess and damage.	Iron	63-67	transferrin	Homo sapiens	4-15
16957011-11	2006	Pro-Caspase-3 expression and Caspase-3 activity increased only in cells treated with Fe-S.	Iron	85-89	caspase 3	Homo sapiens	0-13
16957011-11	2006	Pro-Caspase-3 expression and Caspase-3 activity increased only in cells treated with Fe-S.	Iron	85-89	caspase 3	Homo sapiens	4-13
17373276-0	2006	[Iron metabolism pre and post the erythropoietin era].	Iron	1-5	erythropoietin	Homo sapiens	34-48
17373276-6	2006	Intravenous administration of Vitamin C, by enhancing the release of iron from the reticuloendothelial system towards transferrin increases the circulating iron available for erythropoiesis and contributes to the optimisation of ESA efficacy.	Iron	69-73	transferrin	Homo sapiens	118-129
17373276-6	2006	Intravenous administration of Vitamin C, by enhancing the release of iron from the reticuloendothelial system towards transferrin increases the circulating iron available for erythropoiesis and contributes to the optimisation of ESA efficacy.	Iron	156-160	transferrin	Homo sapiens	118-129
17373277-10	2006	Serum ferritin and transferrin saturation are regarded as the most reliable indicators of iron status.	Iron	90-94	transferrin	Homo sapiens	19-30
17373278-2	2006	However, this diagnostic appears to be essential in so far as its treatment consists in intravenous iron perfusion that allow an optimal efficiency of erythropoietin therapy.	Iron	100-104	erythropoietin	Homo sapiens	151-165
16966351-8	2006	Controlling for these factors, the serum prolactin response pattern differed significantly by infant iron status.	Iron	101-105	prolactin	Homo sapiens	41-50
17373284-8	2006	The assessment of iron store in kidney patient relies on three major markers: transferrin saturation (Trf Sat); ferritin; percentage of hypochromic erythroid cells.	Iron	18-22	transferrin	Homo sapiens	78-89
16966351-4	2006	The objective of this study was to determine the effect of infant iron status on serum prolactin levels after a stressor in early adolescence.	Iron	66-70	prolactin	Homo sapiens	87-96
16962235-0	2006	PANK2 gene analysis confirms genetic heterogeneity in neurodegeneration with brain iron accumulation (NBIA) but mutations are rare in other types of adult neurodegenerative disease.	Iron	83-87	pantothenate kinase 2	Homo sapiens	0-5
17085975-6	2006	During incubation of deoxyribose with cytochrome c and H2O2, damage to the deoxyribose occurred in parallel with the release of iron from cytochrome c.	Iron	128-132	cytochrome c, somatic	Homo sapiens	38-50
17085975-6	2006	During incubation of deoxyribose with cytochrome c and H2O2, damage to the deoxyribose occurred in parallel with the release of iron from cytochrome c.	Iron	128-132	cytochrome c, somatic	Homo sapiens	138-150
17085975-8	2006	These results suggest that H2O2-mediated cytochrome c oligomerization is due to oxidative damage resulting from free radicals generated by a combination of the peroxidase activity of cytochrome c and the Fenton reaction of free iron released from the oxidatively-damaged protein.	Iron	228-232	cytochrome c, somatic	Homo sapiens	41-53
19704569-8	2006	The expression of each of the above DMAS genes is upregulated under Fe-deficient conditions in root tissue, and that of OsDMAS1 and TaDMAS1 are upregulated in shoot tissue.	Iron	68-70	deoxymugineic acid synthase 1-A	Triticum aestivum	132-139
16962235-1	2006	Mutations in the pantothenate kinase 2 gene (PANK2) are the cause of pantothenate kinase associated neurodegeneration (PKAN), an autosomal recessive (AR) disorder characterized by motor symptoms as such as dystonia or parkinsonism, mental retardation, retinitis pigmentosa and iron accumulation in the brain.	Iron	277-281	pantothenate kinase 2	Homo sapiens	17-38
16962235-1	2006	Mutations in the pantothenate kinase 2 gene (PANK2) are the cause of pantothenate kinase associated neurodegeneration (PKAN), an autosomal recessive (AR) disorder characterized by motor symptoms as such as dystonia or parkinsonism, mental retardation, retinitis pigmentosa and iron accumulation in the brain.	Iron	277-281	pantothenate kinase 2	Homo sapiens	45-50
16962235-1	2006	Mutations in the pantothenate kinase 2 gene (PANK2) are the cause of pantothenate kinase associated neurodegeneration (PKAN), an autosomal recessive (AR) disorder characterized by motor symptoms as such as dystonia or parkinsonism, mental retardation, retinitis pigmentosa and iron accumulation in the brain.	Iron	277-281	pantothenate kinase 2	Homo sapiens	69-124
17031035-4	2006	Serum osteocalcin concentration, bone mineral content, bone mineral density, and mechanical strength of the femur were significantly lower in the iron-deficient group than in the control group.	Iron	146-150	bone gamma-carboxyglutamate protein	Rattus norvegicus	6-17
17031976-8	2006	The thermodynamic and kinetic data for NO binding to the new model complexes of P450 (2 and 5) are discussed in reference to earlier results obtained for closely related nitrosylation reactions of cytochrome P450(cam) (in the presence and in the absence of the substrate) and a thiolate-ligated iron(III) model complex.	Iron	295-299	calmodulin 3	Homo sapiens	197-217
16919875-6	2006	Using in vitro studies, we have shown that a chelator-nanoparticle system and the chelator-nanoparticle system complexed with iron, when incubated with human plasma, preferentially adsorb apolipoprotein E and apolipoprotein A-I, that would facilitate transport into and out of the brain via mechanisms used for transporting low-density lipoprotein.	Iron	126-130	apolipoprotein E	Homo sapiens	188-204
16919875-6	2006	Using in vitro studies, we have shown that a chelator-nanoparticle system and the chelator-nanoparticle system complexed with iron, when incubated with human plasma, preferentially adsorb apolipoprotein E and apolipoprotein A-I, that would facilitate transport into and out of the brain via mechanisms used for transporting low-density lipoprotein.	Iron	126-130	apolipoprotein A1	Homo sapiens	209-227
16792528-6	2006	Co-expression of Fes with full-length KAP-1 in human 293T cells stimulated Fes autophosphorylation and led to KAP-1 tyrosine phosphorylation.	Iron	17-20	tripartite motif containing 28	Homo sapiens	110-115
17014579-1	2006	AIM: To assess the effects of iron removal on cytochrome P450 2E1 activity and oxidative stress in dysmetabolic iron overload syndrome.	Iron	30-34	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-65
17010049-6	2006	A significant 2-fold elevation of non-transferrin bound iron (NTBI) was observed in thalassaemia relative to SCD.	Iron	56-60	transferrin	Homo sapiens	38-49
16925790-1	2006	Myeloablative conditioning prior to allogeneic stem cell transplantation causes a rapid increase in transferrin saturation and potentially toxic non-transferrin-bound iron (NTBI) in plasma.	Iron	167-171	transferrin	Homo sapiens	149-160
16925790-2	2006	We have studied the ability of repeatedly administered apotransferrin to maintain this iron in a transferrin-bound form.	Iron	87-91	transferrin	Homo sapiens	58-69
16925790-7	2006	From the increment of iron saturation and the amount of endogenous and administered apotransferrin, an average 180 mumol of iron per day was bound to transferrin during the first 4 d after the start of the conditioning therapy.	Iron	124-128	transferrin	Homo sapiens	87-98
16757684-6	2006	A cytosolic iron starvation phenotype in MtFt-expressing tumors was revealed by increased RNA-binding activity of iron regulatory proteins, and concomitantly both an increase in transferrin receptor levels and a decrease in cytosolic ferritin.	Iron	12-16	transferrin	Homo sapiens	178-189
16641131-7	2006	The effect of iron loading on E-cadherin expression in SW480 and Caco-2 cell lines was examined by promoter assays, real time PCR and western blotting.	Iron	14-18	cadherin 1	Homo sapiens	30-40
16982459-0	2006	Iron absorption during epoetin alfa therapy for chemotherapy-associated anaemia.	Iron	0-4	erythropoietin	Homo sapiens	23-30
16982459-1	2006	Absorption of a physiological dose of ferrous iron was studied in 18 patients with solid malignancy receiving epoetin therapy for mild chemotherapy-associated anemia.	Iron	38-50	erythropoietin	Homo sapiens	110-117
16956363-5	2006	In another study, rats injected with iron showed hepatic toxicity as measured by an increase in lipid peroxides and elevated serum enzymes, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase.	Iron	37-41	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	166-192
17006922-0	2006	Alpha 1-antitrypsin mutations in NAFLD: high prevalence and association with altered iron metabolism but not with liver damage.	Iron	85-89	serpin family A member 1	Homo sapiens	0-19
17006922-2	2006	Heterozygosity for alpha 1-antitrypsin (AAT) mutations is a cofactor of liver damage, and AAT influences inflammation and iron metabolism.	Iron	122-126	serpin family A member 1	Homo sapiens	90-93
17006922-3	2006	This study evaluated the prevalence of the common AAT PiS/PiZ mutants in 353 patients with NAFLD, 195 of whom had hyperferritinemia, versus 114 matched controls and their influence on iron metabolism and the severity of liver damage in the 212 patients submitted to biopsy.	Iron	184-188	serpin family A member 1	Homo sapiens	50-53
17006922-8	2006	The prevalence of non-MM genotypes was higher in patients with hyperferritinemia than in those without (28/195, 14% vs. 10/158, 6%, P = .016), and AAT mutations were associated with higher prevalence of sinusoidal siderosis (17/27, 63% vs. 70/180, 39%; P = .02), and sinusoidal/total iron score (46.3 +/- 38% vs. 25.1 +/- 35%, P = .01).	Iron	284-288	serpin family A member 1	Homo sapiens	147-150
17006922-9	2006	Although ferritin was independently associated with fibrosis (P = .047), AAT mutations favoring sinusoidal iron deposition did not affect liver damage.	Iron	107-111	serpin family A member 1	Homo sapiens	73-76
17006922-10	2006	In conclusion, AAT mutations are associated with hyperferritinemia and sinusoidal iron accumulation, but not with more severe liver damage in NAFLD.	Iron	82-86	serpin family A member 1	Homo sapiens	15-18
16630644-3	2006	We examined the chemical reactivity of AC-supported iron as a catalyst to decompose PCB-153, and varied three decomposition parameters (temperature, time and iron concentration) under an atmosphere of either air or N(2).	Iron	52-56	pyruvate carboxylase	Homo sapiens	84-87
16806171-3	2006	Ceruloplasmin, a protein with ferroxidase activity, and transferrin, an iron binding protein have important roles in maintaining iron homeostasis in cells.	Iron	72-76	transferrin	Homo sapiens	56-67
16806171-3	2006	Ceruloplasmin, a protein with ferroxidase activity, and transferrin, an iron binding protein have important roles in maintaining iron homeostasis in cells.	Iron	129-133	transferrin	Homo sapiens	56-67
16806171-5	2006	In the current study of lens epithelial cells, the effects of ceruloplasmin and transferrin on intracellular distribution and efflux of iron were determined.	Iron	136-140	transferrin	Homo sapiens	80-91
16806171-6	2006	Both ceruloplasmin and transferrin increased iron efflux from these cells and their effects were additive.	Iron	45-49	transferrin	Homo sapiens	23-34
16806171-8	2006	Surprisingly, both transferrin and ceruloplasmin had significant effects on intracellular iron distribution.	Iron	90-94	transferrin	Homo sapiens	19-30
16806171-11	2006	Measurements of an intracellular chelatable iron pool indicated that both transferrin and ceruloplasmin increased the size of this pool at 24 h, but these increases had different downstream effects.	Iron	44-48	transferrin	Homo sapiens	74-85
16641131-11	2006	Iron loading Caco-2 and SW480 cells caused cellular proliferation and E-cadherin repression.	Iron	0-4	cadherin 1	Homo sapiens	70-80
16958665-6	2006	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells that express CYP2E1 (E47 cells) but not control HepG2 cells.	Iron	41-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	89-95
18370738-12	2006	Our data support a direct role of increased body iron in the pathogenesis of insulin resistance, whereas iron overload may also contribute to the development of specific features of the metabolic syndrome, such as fatty liver.	Iron	49-53	insulin	Homo sapiens	77-84
16988136-4	2006	Iron supplementation significantly improved hematocrit and transferrin receptor concentrations but had no influence on maternal folate status or milk folate or iron concentrations.	Iron	0-4	transferrin	Homo sapiens	59-70
16990032-8	2006	However, activities of CAT and GSH-Px enzymes in cord blood erythrocytes and MDA levels in maternal plasma increased in the iron-supplemented group as compared with those from the control group.	Iron	124-128	catalase	Homo sapiens	23-26
16953838-9	2006	The protein levels of ferroportin1 in iron-deficient HCCs were similar as in control livers, and did not increase in HCCs exposed to iron.	Iron	38-42	solute carrier family 40 member 1	Rattus norvegicus	22-34
16953838-10	2006	Hepcidin mRNA levels were decreased in iron-deficient HCCs, rose in response to iron loading and correlated to the tissue iron content.	Iron	39-43	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
16953838-10	2006	Hepcidin mRNA levels were decreased in iron-deficient HCCs, rose in response to iron loading and correlated to the tissue iron content.	Iron	80-84	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
16891647-0	2006	Weekly low-dose treatment with intravenous iron sucrose maintains iron status and decreases epoetin requirement in iron-replete haemodialysis patients.	Iron	43-47	erythropoietin	Homo sapiens	92-99
16891647-1	2006	BACKGROUND: Haemodialysis patients need sustained treatment with intravenous iron because iron deficiency limits the efficacy of recombinant human epoetin therapy in these patients.	Iron	77-81	erythropoietin	Homo sapiens	147-154
16891647-6	2006	After 6 months of intravenous iron sucrose treatment, the mean ferritin value showed a tendency to increase slightly from 405 +/- 159 at baseline to 490 +/- 275 microg/l at the end of the study, but iron, transferrin levels and transferrin saturation did not change.	Iron	30-34	transferrin	Homo sapiens	205-216
17014552-5	2006	The aim of this study is to evaluate the role of CRP and CHr in iron administration and anaemia management in dialysis patients.	Iron	64-68	C-reactive protein	Homo sapiens	49-52
16891647-6	2006	After 6 months of intravenous iron sucrose treatment, the mean ferritin value showed a tendency to increase slightly from 405 +/- 159 at baseline to 490 +/- 275 microg/l at the end of the study, but iron, transferrin levels and transferrin saturation did not change.	Iron	30-34	transferrin	Homo sapiens	228-239
17014552-14	2006	High CRP association with low CHr and low TSAT levels can explain the lack of response to further IV iron therapy.	Iron	101-105	C-reactive protein	Homo sapiens	5-8
17038573-11	2006	The elevation of transferrin-soluble receptors in the 4th and 6th weeks denotes a necessity of iron supplementation for a correct development of the immature hematic cells since blood parameters do not reach normal levels in the 6th postoperative week.	Iron	95-99	transferrin	Homo sapiens	17-28
16917084-0	2006	Erythropoietin depletes iron stores: antioxidant neuroprotection for ischemic stroke?	Iron	24-28	erythropoietin	Homo sapiens	0-14
16759669-3	2006	MRI data, autopsy studies, and a consistent decrease in CSF ferritin all suggest that early-onset RLS is associated with insufficient iron in the brain.	Iron	134-138	RLS1	Homo sapiens	98-101
16759669-4	2006	In this study, we examined the relationship between the iron regulatory hormone hepcidin and RLS.	Iron	56-60	RLS1	Homo sapiens	93-96
16759669-13	2006	Nonetheless, these data support the mounting evidence that there is a biological basis for RLS and the underlying mechanism involves iron management.	Iron	133-137	RLS1	Homo sapiens	91-94
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	100-104	transferrin	Homo sapiens	165-176
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	100-104	transferrin	Homo sapiens	192-203
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	transferrin	Homo sapiens	165-176
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	transferrin	Homo sapiens	192-203
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	transferrin	Homo sapiens	165-176
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	transferrin	Homo sapiens	192-203
16697418-0	2006	p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.	Iron	32-36	mitogen-activated protein kinase 14	Homo sapiens	0-3
16950869-0	2006	Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.	Iron	48-52	transferrin	Homo sapiens	30-41
16697418-0	2006	p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.	Iron	32-36	mitogen-activated protein kinase 1	Homo sapiens	8-11
16697418-5	2006	Of the three MAP kinase blockers used, the selective p38 MAP kinase inhibitor SB203580 and ERK inhibitor PD98059 protected IHOK and HN4 cells against iron chelator-induced cell death, which indicates that the p38 and ERK MAP kinase is a major mediator of apoptosis induced by this iron chelator.	Iron	150-154	mitogen-activated protein kinase 14	Homo sapiens	53-56
16697418-5	2006	Of the three MAP kinase blockers used, the selective p38 MAP kinase inhibitor SB203580 and ERK inhibitor PD98059 protected IHOK and HN4 cells against iron chelator-induced cell death, which indicates that the p38 and ERK MAP kinase is a major mediator of apoptosis induced by this iron chelator.	Iron	150-154	mitogen-activated protein kinase 1	Homo sapiens	91-94
16697418-5	2006	Of the three MAP kinase blockers used, the selective p38 MAP kinase inhibitor SB203580 and ERK inhibitor PD98059 protected IHOK and HN4 cells against iron chelator-induced cell death, which indicates that the p38 and ERK MAP kinase is a major mediator of apoptosis induced by this iron chelator.	Iron	150-154	mitogen-activated protein kinase 14	Homo sapiens	209-212
16697418-5	2006	Of the three MAP kinase blockers used, the selective p38 MAP kinase inhibitor SB203580 and ERK inhibitor PD98059 protected IHOK and HN4 cells against iron chelator-induced cell death, which indicates that the p38 and ERK MAP kinase is a major mediator of apoptosis induced by this iron chelator.	Iron	281-285	mitogen-activated protein kinase 14	Homo sapiens	53-56
16697418-5	2006	Of the three MAP kinase blockers used, the selective p38 MAP kinase inhibitor SB203580 and ERK inhibitor PD98059 protected IHOK and HN4 cells against iron chelator-induced cell death, which indicates that the p38 and ERK MAP kinase is a major mediator of apoptosis induced by this iron chelator.	Iron	281-285	mitogen-activated protein kinase 1	Homo sapiens	91-94
16697418-8	2006	Collectively, these data suggested that p38 and ERK MAP kinase plays an important role in iron chelator-mediated cell death and in the suppression of differentiation of oral immortalized and malignant keratinocytes, by activating a downstream apoptotic cascade that executes the cell death pathway.	Iron	90-94	mitogen-activated protein kinase 14	Homo sapiens	40-43
16697418-8	2006	Collectively, these data suggested that p38 and ERK MAP kinase plays an important role in iron chelator-mediated cell death and in the suppression of differentiation of oral immortalized and malignant keratinocytes, by activating a downstream apoptotic cascade that executes the cell death pathway.	Iron	90-94	mitogen-activated protein kinase 1	Homo sapiens	48-51
16648237-1	2006	Alveolar macrophages express many proteins important in iron homeostasis, including the iron importer divalent metal transport 1 (DMT1) and the iron exporter ferroportin 1 (FPN1) that likely participate in lung defense.	Iron	56-60	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	173-177
16960172-14	2006	CONCLUSION: In children deficient in vitamin A and iron, vitamin A supplementation mobilizes iron from existing stores to support increased erythropoiesis, an effect likely mediated by increases in circulating EPO.	Iron	51-55	erythropoietin	Homo sapiens	210-213
16960172-14	2006	CONCLUSION: In children deficient in vitamin A and iron, vitamin A supplementation mobilizes iron from existing stores to support increased erythropoiesis, an effect likely mediated by increases in circulating EPO.	Iron	93-97	erythropoietin	Homo sapiens	210-213
16648237-5	2006	However, iron had no effect on HAMP expression but was able to upregulate both DMT1 and FPN1 in alveolar macrophages.	Iron	9-13	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	88-92
16648237-11	2006	Our studies suggest that iron mobilization by alveolar macrophages can be affected by iron and LPS via several pathways, including HAMP-mediated degradation of FPN1, and that these cells may use unique regulatory mechanisms to cope with iron imbalance in the lung.	Iron	25-29	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	160-164
16648237-11	2006	Our studies suggest that iron mobilization by alveolar macrophages can be affected by iron and LPS via several pathways, including HAMP-mediated degradation of FPN1, and that these cells may use unique regulatory mechanisms to cope with iron imbalance in the lung.	Iron	86-90	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	160-164
16648237-11	2006	Our studies suggest that iron mobilization by alveolar macrophages can be affected by iron and LPS via several pathways, including HAMP-mediated degradation of FPN1, and that these cells may use unique regulatory mechanisms to cope with iron imbalance in the lung.	Iron	86-90	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	160-164
16603144-1	2006	BACKGROUND: Clinical studies have shown that degree of erythropoiesis, the hypoxic response, and iron status each independently influences transferrin receptor concentration, but there is conflicting information regarding the effect of inflammation on transferrin receptor expression.	Iron	97-101	transferrin	Homo sapiens	139-150
16767397-1	2006	Congenital dyserythropoietic anemia type I (CDA I) is a rare autosomal recessive disorder with ineffective erythropoiesis, characteristic morphological abnormalities of erythroblasts, and iron overloading.	Iron	188-192	codanin 1	Homo sapiens	0-42
16767397-1	2006	Congenital dyserythropoietic anemia type I (CDA I) is a rare autosomal recessive disorder with ineffective erythropoiesis, characteristic morphological abnormalities of erythroblasts, and iron overloading.	Iron	188-192	codanin 1	Homo sapiens	44-49
16950140-0	2006	Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function.	Iron	70-74	solute carrier family 31, member 1	Mus musculus	0-4
16904349-0	2006	Stimulation of non-transferrin iron uptake by iron deprivation in K562 cells.	Iron	31-35	transferrin	Homo sapiens	19-30
16904349-0	2006	Stimulation of non-transferrin iron uptake by iron deprivation in K562 cells.	Iron	46-50	transferrin	Homo sapiens	19-30
16904349-2	2006	The iron uptake after 24-h preincubation in defined iron-free medium was approximately 2-3x higher than after the preincubation in control transferrin-containing medium.	Iron	4-8	transferrin	Homo sapiens	139-150
16904349-7	2006	We conclude that iron deprivation stimulates the uptake of non-transferrin iron in K562 cells and that this stimulation depends on protein synthesis.	Iron	17-21	transferrin	Homo sapiens	63-74
16904349-7	2006	We conclude that iron deprivation stimulates the uptake of non-transferrin iron in K562 cells and that this stimulation depends on protein synthesis.	Iron	75-79	transferrin	Homo sapiens	63-74
16603144-6	2006	CONCLUSION: Our results suggest that inflammation leads to an increase in circulating transferrin receptor concentration that is independent of the degree of erythropoiesis, the hypoxic response and iron status.	Iron	199-203	transferrin	Homo sapiens	86-97
17699372-4	2006	A portion of intravenous iron preparations is redox-active, labile iron available for direct donation to transferrin.	Iron	25-29	transferrin	Homo sapiens	105-116
17699372-4	2006	A portion of intravenous iron preparations is redox-active, labile iron available for direct donation to transferrin.	Iron	67-71	transferrin	Homo sapiens	105-116
17699372-5	2006	In vitro tests show that commonly available intravenous iron formulations have differing capacities to saturate transferrin directly: Iron gluconate &gt; iron sucrose &gt; iron dextran.	Iron	56-60	transferrin	Homo sapiens	112-123
17699374-2	2006	Because serum ferritin is an acute-phase reactant and because the inflammatory state may inhibit the mobilization of iron from reticuloendothelial stores, the scenario of patients with serum ferritin &gt;800 ng/ml, suggesting iron overload, and transferrin saturation &lt;20%, suggesting iron deficiency, has become more common.	Iron	226-230	transferrin	Homo sapiens	245-256
17373268-4	2006	In the circulation iron is bound to transferrin (Tf).	Iron	19-23	transferrin	Homo sapiens	36-47
16488129-9	2006	The expression of WAP mRNA was also significantly (P&lt;.005) increased in the pair-fed group as well as in the low-Fe group when compared to the control group.	Iron	116-118	whey acidic protein	Rattus norvegicus	18-21
16879716-0	2006	Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1.	Iron	42-46	transferrin	Rattus norvegicus	97-108
16879716-6	2006	Immunoprecipitation with transferrin antibodies on brains from Belgrade rats revealed lower uptake of transferrin-bound (59)Fe.	Iron	124-126	transferrin	Rattus norvegicus	25-36
16879716-6	2006	Immunoprecipitation with transferrin antibodies on brains from Belgrade rats revealed lower uptake of transferrin-bound (59)Fe.	Iron	124-126	transferrin	Rattus norvegicus	102-113
16879716-10	2006	In conclusion, BCECs probably mediate iron transport into the brain by segregating iron from transferrin without involvement of DMT1.	Iron	38-42	transferrin	Rattus norvegicus	93-104
16850257-4	2006	Determination of iron status revealed high serum ferritin and transferrin saturation levels in both patients.	Iron	17-21	transferrin	Homo sapiens	62-73
16936158-9	2006	These results further support the hypothesis of a causative role of iron metabolism in the onset of insulin resistance and type 2 diabetes.	Iron	68-72	insulin	Homo sapiens	100-107
16930371-2	2006	Transferrin (Tf) is a major transport protein for both iron and Al.	Iron	55-59	transferrin	Homo sapiens	0-11
16930371-2	2006	Transferrin (Tf) is a major transport protein for both iron and Al.	Iron	55-59	transferrin	Homo sapiens	13-15
16930371-3	2006	Moreover, it has been demonstrated that defective binding of iron and Al to the Tf variant C2 could be present in AD.	Iron	61-65	transferrin	Homo sapiens	80-82
16787928-1	2006	In prokaryotes and yeast, the general mechanism of biogenesis of iron-sulfur (Fe-S) clusters involves activities of several proteins among which IscS and Nfs1p provide, through cysteine desulfuration, elemental sulfide for Fe-S core formation.	Iron	78-82	cysteine desulfurase	Saccharomyces cerevisiae S288C	154-159
16787928-1	2006	In prokaryotes and yeast, the general mechanism of biogenesis of iron-sulfur (Fe-S) clusters involves activities of several proteins among which IscS and Nfs1p provide, through cysteine desulfuration, elemental sulfide for Fe-S core formation.	Iron	223-227	cysteine desulfurase	Saccharomyces cerevisiae S288C	154-159
16787928-6	2006	Reduction of Fe-S enzyme activities occurred earlier and more markedly in the cytosol than in mitochondria, suggesting that there is a mechanism that primarily dedicates m-Nfs1 to the biogenesis of mitochondrial Fe-S clusters in order to maintain cell survival.	Iron	13-17	cysteine desulfurase	Saccharomyces cerevisiae S288C	172-176
16787928-6	2006	Reduction of Fe-S enzyme activities occurred earlier and more markedly in the cytosol than in mitochondria, suggesting that there is a mechanism that primarily dedicates m-Nfs1 to the biogenesis of mitochondrial Fe-S clusters in order to maintain cell survival.	Iron	212-216	cysteine desulfurase	Saccharomyces cerevisiae S288C	172-176
16781861-15	2006	Serum total iron binding capacity [transferrin (Tf)] was not changed by Cu deficiency or by Fe supplementation; however, percent Tf saturation was reduced in CuD rats but was not enhanced by Fe supplementation.	Iron	12-16	transferrin	Rattus norvegicus	35-46
16870258-7	2006	Hfe and AAT are involved in iron metabolism and their polymorphisms may contribute to hepatosteatosis and altered homeostasis of lipids (role of APOE), iron, and trace minerals.	Iron	28-32	serpin family A member 1	Homo sapiens	8-11
16870258-7	2006	Hfe and AAT are involved in iron metabolism and their polymorphisms may contribute to hepatosteatosis and altered homeostasis of lipids (role of APOE), iron, and trace minerals.	Iron	152-156	serpin family A member 1	Homo sapiens	8-11
16870258-14	2006	The effects of APOE, Hfe, and AAT on glucose, lipid, iron and trace mineral homeostasis may affect normal development and aging of the nervous system in addition to their effects on outcome of toxic environmental and occupational exposures and susceptibility and outcome of neurodegenerative illnesses.	Iron	53-57	apolipoprotein E	Homo sapiens	15-19
16870258-14	2006	The effects of APOE, Hfe, and AAT on glucose, lipid, iron and trace mineral homeostasis may affect normal development and aging of the nervous system in addition to their effects on outcome of toxic environmental and occupational exposures and susceptibility and outcome of neurodegenerative illnesses.	Iron	53-57	serpin family A member 1	Homo sapiens	30-33
17373268-4	2006	In the circulation iron is bound to transferrin (Tf).	Iron	19-23	transferrin	Homo sapiens	49-51
17101452-3	2006	Transferrin synthesized by oligodendrocytes in the brain binds much of the iron that traverses the blood-brain barrier after oxidation of the iron, most likely by a glycophosphosinositide-linked ceruloplasmin found in astrocytic foot processes that ensheathe brain endothelial cells.	Iron	75-79	transferrin	Homo sapiens	0-11
16844841-7	2006	Among further newly implicated proteins are IRT3 and ZIP10, which have been proposed to contribute to cytoplasmic Zn influx, and FRD3 required for iron partitioning in A. thaliana.	Iron	147-151	MATE efflux family protein	Arabidopsis thaliana	129-133
17163184-4	2006	was to asses iron status in aspect of plasmatic transferrin receptors concentration among children and youth with chronic gastritis with or without Helicobacter pylori infection.	Iron	13-17	transferrin	Homo sapiens	48-59
16965592-0	2006	Increased iron absorption during autologous blood donation supported by recombinant human erythropoietin therapy.	Iron	10-14	erythropoietin	Homo sapiens	90-104
17101452-1	2006	Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier.	Iron	6-10	transferrin	Homo sapiens	52-63
17101452-2	2006	Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin.	Iron	18-22	transferrin	Homo sapiens	0-11
17101452-3	2006	Transferrin synthesized by oligodendrocytes in the brain binds much of the iron that traverses the blood-brain barrier after oxidation of the iron, most likely by a glycophosphosinositide-linked ceruloplasmin found in astrocytic foot processes that ensheathe brain endothelial cells.	Iron	142-146	transferrin	Homo sapiens	0-11
17101456-1	2006	Neuroferritinopathy (MIM 606159, also labeled hereditary ferritinopathy and neurodegeneration with brain iron accumulation type 2, NBIA2) is an adult-onset progressive movement disorder caused by mutations in the ferritin light chain gene (FTL1).	Iron	105-109	phospholipase A2 group VI	Homo sapiens	131-136
16925422-1	2006	Herein we report the synthesis and properties of Fe(55)Pt(45) nanoparticles, both monodisperse and self-assembled into hexagonal close-packed and cubic arrays of 4.0 +/- 0.2 nm size in an L1(0) structure, obtained by a modified polyol process.	Iron	49-51	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	188-193
16793765-0	2006	The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding.	Iron	25-29	transferrin	Homo sapiens	47-58
16793765-1	2006	Serum transferrin reversibly binds iron in each of two lobes and delivers it to cells by a receptor-mediated, pH-dependent process.	Iron	35-39	transferrin	Homo sapiens	6-17
16782706-0	2006	An iron-induced nitric oxide burst precedes ubiquitin-dependent protein degradation for Arabidopsis AtFer1 ferritin gene expression.	Iron	3-7	ferretin 1	Arabidopsis thaliana	100-106
16844240-8	2006	However, significantly elevated transcript levels of DMT1 and ferroportin1 (2.7- and 3.8-fold induction, respectively) were seen in the gastrointestinal tract, and DMT1 in the gills (1.8-fold induction) of zebrafish fed a low Fe diet.	Iron	226-228	solute carrier family 40 member 1	Danio rerio	62-74
16782706-6	2006	This compound acts downstream of iron and upstream of a PP2A-type phosphatase to promote an increase of AtFer1 mRNA level.	Iron	33-37	ferretin 1	Arabidopsis thaliana	104-110
16782706-4	2006	By combining pharmacological and imaging approaches in an Arabidopsis cell culture system, we have identified several elements in the signal transduction pathway leading to the increase of AtFer1 transcript level after iron treatment.	Iron	219-223	ferretin 1	Arabidopsis thaliana	189-195
16782706-7	2006	The AtFer1 gene transcription has been previously shown to be repressed under low iron conditions with the involvement of the cis-acting element iron-dependent regulatory sequence identified within the AtFer1 promoter sequence.	Iron	82-86	ferretin 1	Arabidopsis thaliana	4-10
16782706-7	2006	The AtFer1 gene transcription has been previously shown to be repressed under low iron conditions with the involvement of the cis-acting element iron-dependent regulatory sequence identified within the AtFer1 promoter sequence.	Iron	145-149	ferretin 1	Arabidopsis thaliana	4-10
16737972-12	2006	Collectively, these findings indicate that alcohol metabolism-mediated oxidative stress regulates hepcidin transcription via C/EBPalpha, which in turn leads to increased duodenal iron transport.	Iron	179-183	CCAAT enhancer binding protein alpha	Homo sapiens	125-135
16782706-7	2006	The AtFer1 gene transcription has been previously shown to be repressed under low iron conditions with the involvement of the cis-acting element iron-dependent regulatory sequence identified within the AtFer1 promoter sequence.	Iron	145-149	ferretin 1	Arabidopsis thaliana	202-208
16609065-3	2006	Previously, we identified a mammalian ferrireductase, Steap3, critical for erythroid iron homeostasis.	Iron	85-89	STEAP3 metalloreductase	Homo sapiens	54-60
16609065-4	2006	Now, through homology, expression, and functional studies, we characterize all 4 members of this protein family and demonstrate that 3 of them, Steap2, Steap3, and Steap4, are not only ferrireductases but also cupric reductases that stimulate cellular uptake of both iron and copper in vitro.	Iron	267-271	STEAP3 metalloreductase	Homo sapiens	152-158
16878946-4	2006	Crystal data for the Fe compound follow: monoclinic, P2(1)/n (No.	Iron	21-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-58
16769722-0	2006	Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria.	Iron	35-39	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-5
16769722-0	2006	Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria.	Iron	44-48	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-5
16769722-1	2006	Yeast Mrs3p and Mrs4p are evolutionarily conserved mitochondrial carrier proteins that transport iron into mitochondria under some conditions.	Iron	97-101	Fe(2+) transporter	Saccharomyces cerevisiae S288C	6-11
16769722-8	2006	New cluster formation was dependent on iron addition to mitochondria, and the iron concentration dependence was shifted dramatically upward in the Deltamrs3/4 mutant, indicating a role of Mrs3/4p in iron transport.	Iron	78-82	Fe(2+) transporter	Saccharomyces cerevisiae S288C	188-192
16769722-8	2006	New cluster formation was dependent on iron addition to mitochondria, and the iron concentration dependence was shifted dramatically upward in the Deltamrs3/4 mutant, indicating a role of Mrs3/4p in iron transport.	Iron	78-82	Fe(2+) transporter	Saccharomyces cerevisiae S288C	188-192
16769722-12	2006	These findings show that Mrs3/4p transports iron into mitochondria, whereas frataxin makes iron already within mitochondria available for Fe-S cluster synthesis.	Iron	44-48	Fe(2+) transporter	Saccharomyces cerevisiae S288C	25-29
16937477-8	2006	The positive hepatic iron stain was significantly associated with the values of alanine aminotransferase (ALT) (P = 0.017), ferritin (P = 0.008), serum iron (P = 0.019) and transferrin saturation (P = 0.003).	Iron	21-25	transferrin	Homo sapiens	173-184
16878956-5	2006	Despite mitigating the high effective charge of the iron(IV) center, the substitution of the MeCN ligand with monoanionic ligands X- decreases the thermal stability of [Fe(IV)(O)(TPA)]2+ complexes.	Iron	52-56	plasminogen activator, tissue type	Homo sapiens	179-182
16513102-1	2006	BACKGROUND: In vitro glycation of transferrin leads to increased oxidative stress by impairing iron-binding antioxidant capacity.	Iron	95-99	transferrin	Homo sapiens	34-45
16565419-5	2006	In the liver, Fp1 was modulated in opposite directions by iron and LPS, and its regulation in Hfe-deficient mice was similar to that observed in wild-type mice.	Iron	58-62	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	14-17
16841247-10	2006	These results sustain a model by which direct interaction between DMT1 and HFE-beta2m in the apical membrane of Caco-2 cells result in down-regulation of apical iron uptake activity.	Iron	161-165	charged multivesicular body protein 2B	Homo sapiens	66-70
16513102-7	2006	Total iron-binding capacity was lower in type 1 diabetes (63+/-9 versus 69+/-12 micromol/l in type 2, p&lt;0.05) and was mainly determined by transferrin concentration.	Iron	6-10	transferrin	Homo sapiens	142-153
16793032-6	2006	CONCLUSION: The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I.	Iron	44-48	tumor necrosis factor	Homo sapiens	114-123
16793032-6	2006	CONCLUSION: The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I.	Iron	44-48	interleukin 6	Homo sapiens	125-129
16793032-6	2006	CONCLUSION: The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I.	Iron	44-48	insulin like growth factor 1	Homo sapiens	262-267
16841247-2	2006	Based on the observation that ectopic expression of HFE strongly inhibits apical iron uptake (Arredondo et al., 2001, FASEB J 15, 1276-1278), a negative regulation of HFE on the apical membrane transporter DMT1 was proposed as a mechanism by which HFE regulates iron absorption.	Iron	81-85	charged multivesicular body protein 2B	Homo sapiens	206-210
16793032-0	2006	Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron.	Iron	89-93	insulin like growth factor 1	Homo sapiens	28-33
16793930-0	2006	Tumor necrosis factor-alpha -308G&gt;A allelic variant modulates iron accumulation in patients with hereditary hemochromatosis.	Iron	65-69	tumor necrosis factor	Homo sapiens	0-27
16477270-12	2006	CONCLUSION: These results demonstrate unequivocally that in a short-term preclinical evaluation, dietary Fen supplementation reduced the triglyceride accumulation in the liver, a hallmark feature of hepatic steatosis without affecting the plasma insulin or glucose levels in Zucker obese rats and suggest that TNF-alpha may play an important role in this process.	Iron	105-108	tumor necrosis factor	Rattus norvegicus	310-319
16793930-1	2006	BACKGROUND: In vitro and animal studies suggest that tumor necrosis factor alpha (TNF-alpha) modulates intestinal iron transport.	Iron	114-118	tumor necrosis factor	Homo sapiens	53-80
16793930-1	2006	BACKGROUND: In vitro and animal studies suggest that tumor necrosis factor alpha (TNF-alpha) modulates intestinal iron transport.	Iron	114-118	tumor necrosis factor	Homo sapiens	82-91
16793930-2	2006	We hypothesized that the effect of TNF-alpha might be particularly relevant if iron absorption is not effectively controlled by the HFE gene.	Iron	79-83	tumor necrosis factor	Homo sapiens	35-44
16793930-3	2006	METHODS: In patients with homozygous C282Y hemochromatosis, we investigated the influence of TNF-alpha -308G&gt;A allelic variant on total body iron overload, determined in all patients by measuring iron removed during depletion therapy, and hepatic iron index and need for phlebotomy to prevent iron reaccumulation, measured in patient subgroups.	Iron	144-148	tumor necrosis factor	Homo sapiens	93-102
16793930-5	2006	Mean (SD) total body iron overload was increased 2-fold in TNF-alpha -308A allele carriers [10.9 (7.6) g] compared with homozygous carriers of the G allele [5.6 (5.0) g, P&lt;0.001].	Iron	21-25	tumor necrosis factor	Homo sapiens	59-68
16793930-6	2006	Hepatic iron index differed markedly between TNF-alpha -308A allele carriers [5.6 (3.5) micromol/g/year] and homozygous G allele carriers [3.1 (2.2) micromol/g/year, P=0.040, n=30].	Iron	8-12	tumor necrosis factor	Homo sapiens	45-54
16793930-7	2006	After iron depletion, the need for phlebotomy to prevent iron reaccumulation (maintenance therapy) was substantially higher in TNF-alpha -308A allele carriers than in homozygous G allele carriers (P=0.014, n=73).	Iron	57-61	tumor necrosis factor	Homo sapiens	127-136
16793930-9	2006	CONCLUSION: TNF-alpha -308G&gt;A allelic variant modulates iron accumulation in patients with hereditary (homozygous C282Y) hemochromatosis, but the effect of the TNF-alpha -308A allele on clinical manifestations of hemochromatosis was less accentuated than expected from the increased iron load associated with this allele.	Iron	59-63	tumor necrosis factor	Homo sapiens	12-21
16911529-1	2006	The discovery of iron-responsive elements (IREs), along with the identification of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of intracellular iron homeostasis.	Iron	17-21	iron responsive element binding protein 2	Homo sapiens	115-119
16911529-1	2006	The discovery of iron-responsive elements (IREs), along with the identification of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of intracellular iron homeostasis.	Iron	83-87	iron responsive element binding protein 2	Homo sapiens	115-119
16911529-1	2006	The discovery of iron-responsive elements (IREs), along with the identification of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of intracellular iron homeostasis.	Iron	83-87	iron responsive element binding protein 2	Homo sapiens	115-119
17015263-0	2006	Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.	Iron	80-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
17015263-1	2006	The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-110
17015263-1	2006	The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
16740411-7	2006	RESULTS: The mean iron index from the SN was significantly lower in the early-onset RLS compared to controls (t=2.5, P=0.016), while late-onset RLS and controls did not differ.	Iron	18-22	RLS1	Homo sapiens	84-87
16914832-2	2006	Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that function through post-transcriptional interactions with RNA stem loop structures called iron-responsive elements.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	158-162
16914832-2	2006	Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that function through post-transcriptional interactions with RNA stem loop structures called iron-responsive elements.	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	158-162
16914832-2	2006	Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that function through post-transcriptional interactions with RNA stem loop structures called iron-responsive elements.	Iron	258-262	iron responsive element binding protein 2	Homo sapiens	158-162
16914832-3	2006	As the primary mediator of iron homeostasis in neuronal cells, IRP2 is a strong candidate for polymorphisms that could impact AD pathogenesis.	Iron	27-31	iron responsive element binding protein 2	Homo sapiens	63-67
16595158-1	2006	BACKGROUND/AIMS: Unresponsiveness to IFN-alpha is common in chronic hepatitis C. Since conditions associated with an increased oxidative stress (advanced age, steatosis, fibrosis, iron overload, and alcohol consumption) reduce the likelihood of response, we hypothesized that oxidative stress may affect the antiviral actions of IFN-alpha.	Iron	180-184	interferon alpha 1	Homo sapiens	37-46
17037839-3	2006	Irradiation of the NDI in solution with UV light (365 nm), in the presence of cyt c, resulted in the reduction of the heme iron from the Fe3+ to the Fe2+ state.	Iron	123-127	cytochrome c, somatic	Homo sapiens	78-83
16684766-8	2006	Cysteine desulfurases, such as yeast NFS1, are required for sulfur addition to iron-sulfur clusters and other sulfur-requiring processes.	Iron	79-83	cysteine desulfurase	Saccharomyces cerevisiae S288C	37-41
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	96-100	iron responsive element binding protein 2	Homo sapiens	43-47
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	166-170	iron responsive element binding protein 2	Homo sapiens	43-47
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	166-170	iron responsive element binding protein 2	Homo sapiens	43-47
16850017-4	2006	Although IRP2 is homologous to IRP1, IRP2 activity is regulated primarily by iron-dependent degradation through the ubiquitin-proteasomal system in iron-replete cells.	Iron	77-81	iron responsive element binding protein 2	Homo sapiens	37-41
16850017-4	2006	Although IRP2 is homologous to IRP1, IRP2 activity is regulated primarily by iron-dependent degradation through the ubiquitin-proteasomal system in iron-replete cells.	Iron	148-152	iron responsive element binding protein 2	Homo sapiens	37-41
16850017-5	2006	Targeted deletions of IRP1 and IRP2 in animals have demonstrated that IRP2 is the chief physiologic iron sensor.	Iron	100-104	iron responsive element binding protein 2	Homo sapiens	31-35
16850017-5	2006	Targeted deletions of IRP1 and IRP2 in animals have demonstrated that IRP2 is the chief physiologic iron sensor.	Iron	100-104	iron responsive element binding protein 2	Homo sapiens	70-74
16766163-6	2006	The alterations in ceruloplasmin and transferrin levels may lead to abnormal iron and copper metabolism in autism.	Iron	77-81	transferrin	Homo sapiens	37-48
16740411-9	2006	CONCLUSIONS: The current MRI results in combination with previous autopsy data support the role of low brain iron in the SN in at least those with early-onset RLS symptoms.	Iron	109-113	RLS1	Homo sapiens	159-162
16815956-3	2006	YSL1 and YSL3 are similar to the maize (Zea mays) YS1 phytosiderophore transporter (ZmYS1) and the AtYSL2 iron (Fe)-nicotianamine transporter, and are predicted to transport metal-nicotianamine complexes into cells.	Iron	106-110	YELLOW STRIPE like 1	Arabidopsis thaliana	0-4
16815956-3	2006	YSL1 and YSL3 are similar to the maize (Zea mays) YS1 phytosiderophore transporter (ZmYS1) and the AtYSL2 iron (Fe)-nicotianamine transporter, and are predicted to transport metal-nicotianamine complexes into cells.	Iron	112-114	YELLOW STRIPE like 1	Arabidopsis thaliana	0-4
16740411-1	2006	OBJECTIVE: Cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) and autopsy studies have suggested that brain iron may be reduced in restless legs syndrome (RLS).	Iron	117-121	RLS1	Homo sapiens	164-167
16740411-2	2006	Further analysis of the data also suggests that diminished brain iron may selectively be for early-onset RLS.	Iron	65-69	RLS1	Homo sapiens	105-108
16740411-4	2006	In this study our primary hypothesis was that substantia nigra (SN) iron index would be decreased in early-onset RLS compared to controls.	Iron	68-72	RLS1	Homo sapiens	113-116
16890145-0	2006	Chronic iron overload stimulates hepatocyte proliferation and cyclin D1 expression in rodent liver.	Iron	8-12	cyclin D1	Rattus norvegicus	62-71
16890145-7	2006	Of these growth-associated factors, only TNF-alpha messenger RNA (mRNA) was significantly increased by iron loading (about 3-fold; P = 0.005).	Iron	103-107	tumor necrosis factor	Rattus norvegicus	41-50
16890145-8	2006	Because cyclin D1 is required for entry of hepatocytes into the cell cycle after partial hepatectomy or treatment with direct mitogens, levels of immunoreactive cyclin D1 were examined and found to be significantly increased in the iron-loaded livers.	Iron	232-236	cyclin D1	Rattus norvegicus	8-17
16890145-8	2006	Because cyclin D1 is required for entry of hepatocytes into the cell cycle after partial hepatectomy or treatment with direct mitogens, levels of immunoreactive cyclin D1 were examined and found to be significantly increased in the iron-loaded livers.	Iron	232-236	cyclin D1	Rattus norvegicus	161-170
16890145-9	2006	The increase in cyclin D1 protein in the iron-loaded livers was paralleled by an increase in the abundance of its transcript as measured by real-time PCR.	Iron	41-45	cyclin D1	Rattus norvegicus	16-25
16863591-3	2006	PRESENTATION OF THE HYPOTHESIS: Cobalt, a naturally-occurring element with properties similar to those of iron and nickel, induces a marked and stable polycythemic response through a more efficient transcription of the erythropoietin gene.	Iron	106-110	erythropoietin	Homo sapiens	219-233
16889691-6	2006	During the incubation of deoxyribose with cytochrome c and H2O2, the damage to deoxyribose increased in a time-dependent manner, suggesting that the released iron ions may participate in a Fenton-like reaction to produce dOH radicals that may cause the DNA cleavage.	Iron	158-162	cytochrome c, somatic	Homo sapiens	42-54
16889691-7	2006	Evidence that the iron-specific chelator, desferoxamine (DFX), prevented the DNA cleavage induced by the cytochrome c/H2O2 system supports this mechanism.	Iron	18-22	cytochrome c, somatic	Homo sapiens	105-117
16889691-8	2006	Thus we suggest that DNA cleavage is mediated via the generation of dOH by a combination of the peroxidase reaction of cytochrome c and the Fenton-like reaction of free iron ions released from oxidatively damaged cytochrome c in the cytochrome c/H2O2 system.	Iron	169-173	cytochrome c, somatic	Homo sapiens	213-225
16889691-8	2006	Thus we suggest that DNA cleavage is mediated via the generation of dOH by a combination of the peroxidase reaction of cytochrome c and the Fenton-like reaction of free iron ions released from oxidatively damaged cytochrome c in the cytochrome c/H2O2 system.	Iron	169-173	cytochrome c, somatic	Homo sapiens	213-225
16889691-5	2006	Incubation of cytochrome c with H2O2 resulted in a time-dependent release of iron ions from the cytochrome c molecule.	Iron	77-81	cytochrome c, somatic	Homo sapiens	14-26
16889691-5	2006	Incubation of cytochrome c with H2O2 resulted in a time-dependent release of iron ions from the cytochrome c molecule.	Iron	77-81	cytochrome c, somatic	Homo sapiens	96-108
16910777-7	2006	The lipid hydroperoxide scavengers, beta-hydroxytoluene and trolox, and the iron chelator, desferroxamine, showed partial recovery of TNF-induced apoptosis.	Iron	76-80	tumor necrosis factor	Homo sapiens	134-137
16856062-29	2006	The increased risk for ROP may be associated with use of higher doses of supplemental of iron in the EPO group than in the control group.	Iron	89-93	erythropoietin	Homo sapiens	101-104
16679315-1	2006	In mammalian cells, iron homeostasis is largely regulated by post-transcriptional control of gene expression through the binding of iron-regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) contained in the untranslated regions of target mRNAs.	Iron	20-24	iron responsive element binding protein 2	Homo sapiens	167-171
16679315-1	2006	In mammalian cells, iron homeostasis is largely regulated by post-transcriptional control of gene expression through the binding of iron-regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) contained in the untranslated regions of target mRNAs.	Iron	132-136	iron responsive element binding protein 2	Homo sapiens	167-171
16679315-2	2006	IRP2 is the dominant iron sensor in mammalian cells under normoxia, but IRP1 is the more ancient protein in evolutionary terms and has an additional function as a cytosolic aconitase.	Iron	21-25	iron responsive element binding protein 2	Homo sapiens	0-4
16732293-5	2006	Here we show that three members of this subfamily of proteins demethylate H3K9me3/me2 in vitro through a hydroxylation reaction requiring iron and alpha-ketoglutarate as cofactors.	Iron	138-142	malic enzyme 2	Homo sapiens	74-85
16566752-6	2006	We found a significant (P&lt;0.05) fall in serum iron 3 h post-TNFalpha exposure.	Iron	49-53	tumor necrosis factor	Mus musculus	63-71
16675719-7	2006	CONCLUSIONS: Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle.	Iron	30-34	fibrinogen beta chain	Homo sapiens	108-118
16566752-9	2006	Hepatic hepcidin mRNA levels remained unchanged, whereas splenic hepcidin mRNA expression was reduced at 24 h. In conclusion, we provide evidence that TNFalpha may contribute to anaemia of chronic disease by iron sequestration in the spleen and by reduced duodenal iron transfer, which seems to be due to increased enterocyte iron binding by ferritin and a loss of IREG1 function.	Iron	208-212	tumor necrosis factor	Mus musculus	151-159
16806534-1	2006	Fungi have a remarkable capacity to take up iron when present in any of a wide variety of forms, which include free iron ions, low-affinity iron chelates, siderophore-iron chelates, transferrin, heme, and hemoglobin.	Iron	44-48	transferrin	Homo sapiens	182-193
16766055-6	2006	A combination of classical genetics, differential expression and genomic analysis has led to the identification of homologues of components known to operate in fungi and animals (e.g., Fox1, Ftr1, Fre1, Fer1, Ctr1/2) as well as novel molecules involved in copper and iron nutrition (Crr1, Fea1/2).	Iron	267-271	uncharacterized protein	Chlamydomonas reinhardtii	203-207
16566752-9	2006	Hepatic hepcidin mRNA levels remained unchanged, whereas splenic hepcidin mRNA expression was reduced at 24 h. In conclusion, we provide evidence that TNFalpha may contribute to anaemia of chronic disease by iron sequestration in the spleen and by reduced duodenal iron transfer, which seems to be due to increased enterocyte iron binding by ferritin and a loss of IREG1 function.	Iron	265-269	tumor necrosis factor	Mus musculus	151-159
16566752-9	2006	Hepatic hepcidin mRNA levels remained unchanged, whereas splenic hepcidin mRNA expression was reduced at 24 h. In conclusion, we provide evidence that TNFalpha may contribute to anaemia of chronic disease by iron sequestration in the spleen and by reduced duodenal iron transfer, which seems to be due to increased enterocyte iron binding by ferritin and a loss of IREG1 function.	Iron	265-269	tumor necrosis factor	Mus musculus	151-159
16943596-1	2006	Paraoxonase (PON1) protects low and high-density lipoproteins (LDL and HDL) against oxidation induced by reactive oxygen species formation facilitated by iron (Fe) and copper (Cu) ions.	Iron	154-158	paraoxonase 1	Homo sapiens	13-17
16819174-0	2006	The involvement of transferrin in the uptake of iron-59 by hepatocytes of carbon tetrachloride-damaged rats.	Iron	48-52	transferrin	Rattus norvegicus	19-30
16819174-2	2006	It had been reported that the binding affinity of Iron-59 ((59)Fe) to Tf was greater than that of (67)Ga.	Iron	50-54	transferrin	Rattus norvegicus	70-72
16828895-2	2006	Various SOD enzymes have been characterized that employ either a copper, manganese, iron or nickel co-factor to carry out the disproportionation of superoxide.	Iron	84-88	superoxide dismutase 1	Homo sapiens	8-11
16943596-1	2006	Paraoxonase (PON1) protects low and high-density lipoproteins (LDL and HDL) against oxidation induced by reactive oxygen species formation facilitated by iron (Fe) and copper (Cu) ions.	Iron	160-162	paraoxonase 1	Homo sapiens	13-17
16858498-10	2006	Of those with an elevated liver iron concentration (greater than 35 micromol/g dry weight), 71% had a transferrin saturation greater than 50% (88% of C282Y homozygotes and 43% of non-C282Y homozygotes).	Iron	32-36	transferrin	Homo sapiens	102-113
16707273-0	2006	Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF.	Iron	51-55	transferrin	Homo sapiens	27-38
16816791-6	2006	The pathogenesis of RLS involves dopaminergic dysfunction, iron metabolism, and abnormalities in supraspinal inhibition.	Iron	59-63	RLS1	Homo sapiens	20-23
17369904-1	2006	Clinical study of the efficiency of Poetam (affinity-purified antibodies to recombinant human erythropoietin) in the treatment of anemia in patients with pubertal uterine hemorrhages proved that combined therapy with Poetam and iron preparation normalized erythron parameters, structural and metabolic status of erythrocytes, and ferrokinetic parameters of the peripheral blood sooner than monotherapy with Poetam or sorbifer.	Iron	228-232	erythropoietin	Homo sapiens	94-108
16691135-8	2006	Treatment options for Fe-related anemias in critical illness include Fe replacement and recombinant human erythropoietin therapy.	Iron	22-24	erythropoietin	Homo sapiens	106-120
16707273-1	2006	Non-transferrin bound iron (NTBI) in serum is cleared rapidly by hepatocytes, although the mechanisms of NTBI uptake by hepatocytes are poorly understood.	Iron	22-26	transferrin	Homo sapiens	4-15
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	8-12	transferrin	Homo sapiens	128-139
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	118-122	transferrin	Homo sapiens	128-139
16773207-5	2006	YC-1 blocked the HIF-1alpha induction by hypoxia, iron chelation, and proteasomal inhibition and also degraded ectopically expressed HIF-1alpha.	Iron	50-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
16059695-5	2006	Our findings raise the possibility that iron dysregulation mediated by allelic effects of SLC11A1 may contribute to IBD susceptibility.	Iron	40-44	solute carrier family 11 member 1	Homo sapiens	90-97
17007361-6	2006	It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.	Iron	84-88	interleukin 6 receptor	Homo sapiens	56-61
16624972-2	2006	E47 cells (HepG2 cells transfected with human CYP2E1 cDNA) exposed to 25 microM iron-nitrilotriacetate+5 microM arachidonic acid (AA+Fe) developed higher toxicity than C34 cells (HepG2 cells transfected with empty plasmid).	Iron	133-135	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-52
16624972-4	2006	Treatment of E47, but not C34 cells, with arachidonic acid and iron (AA+Fe) led to a decrease in the phosphorylation state of AKT.	Iron	63-67	AKT serine/threonine kinase 1	Homo sapiens	126-129
16624972-4	2006	Treatment of E47, but not C34 cells, with arachidonic acid and iron (AA+Fe) led to a decrease in the phosphorylation state of AKT.	Iron	72-74	AKT serine/threonine kinase 1	Homo sapiens	126-129
16624972-6	2006	LY294002 and down-regulation of endogenous AKT with small interference RNAs increased the toxicity of AA+Fe in E47 cells.	Iron	105-107	AKT serine/threonine kinase 1	Homo sapiens	43-46
16878272-6	2006	CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide, and in the presence of iron catalysts, it produces powerful oxidants such as the hydroxyl radical.	Iron	148-152	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
16818564-3	2006	We hypothesized that combined administration of vitamin B12 and folate with erythropoietin and iron would enhance erythropoietin-induced erythropoiesis.	Iron	95-99	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	56-59
16818564-3	2006	We hypothesized that combined administration of vitamin B12 and folate with erythropoietin and iron would enhance erythropoietin-induced erythropoiesis.	Iron	95-99	erythropoietin	Homo sapiens	114-128
16818564-9	2006	CONCLUSIONS: With the limitation of a slight imbalance in baseline data between the study groups, combined therapy with vitamin B12, folate, erythropoietin, and orally and intravenously administered iron seemed more effective in stimulating erythropoiesis among premature infants, compared with erythropoietin, iron, and low-dose folate alone.	Iron	199-203	erythropoietin	Homo sapiens	295-309
16818564-9	2006	CONCLUSIONS: With the limitation of a slight imbalance in baseline data between the study groups, combined therapy with vitamin B12, folate, erythropoietin, and orally and intravenously administered iron seemed more effective in stimulating erythropoiesis among premature infants, compared with erythropoietin, iron, and low-dose folate alone.	Iron	311-315	erythropoietin	Homo sapiens	141-155
16772451-0	2006	Erythrocyte iron incorporation but not absorption is increased by intravenous iron administration in erythropoietin-treated premature infants.	Iron	12-16	erythropoietin	Homo sapiens	101-115
16772451-0	2006	Erythrocyte iron incorporation but not absorption is increased by intravenous iron administration in erythropoietin-treated premature infants.	Iron	78-82	erythropoietin	Homo sapiens	101-115
16772451-11	2006	We conclude that IV sucrose Fe administered in combination with EPO to very-low-birth weight premature infants significantly increases RBC Fe incorporation and erythropoiesis more than EPO alone, but without increasing iron absorption.	Iron	139-141	erythropoietin	Homo sapiens	64-67
16503166-7	2006	Moreover, we first demonstrated that laser capture microdissection coupled with X-ray fluorescence microscopy can be applied to determine elemental profiles (S, Fe, Cu, and Zn) in Abeta amyloid plaques.	Iron	161-163	amyloid beta precursor protein	Homo sapiens	180-185
16783378-0	2006	PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron.	Iron	95-99	phospholipase A2 group VI	Homo sapiens	0-6
16783378-0	2006	PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron.	Iron	95-99	phospholipase A2 group IB	Homo sapiens	19-35
16783378-2	2006	We mapped a locus for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA) to chromosome 22q12-q13 and identified mutations in PLA2G6, encoding a calcium-independent group VI phospholipase A2, in NBIA, INAD and the related Karak syndrome.	Iron	94-98	phospholipase A2 group VI	Homo sapiens	171-177
16925107-6	2006	iron (iron dextran or ferric gluconate) increases the hematopoietic response rates in cancer patients who were receiving chemotherapy and treated with epoetin alfa (Procrit) for anemia.	Iron	0-4	erythropoietin	Homo sapiens	151-158
16925107-10	2006	iron in patients treated with epoetin alfa or darbepoetin alfa (Aranesp) for chemotherapy-induced anemia should lead to a greater understanding of the role of i.v.	Iron	0-4	erythropoietin	Homo sapiens	30-37
16648636-1	2006	The transcription factors Aft1 and Aft2 from Saccharomyces cerevisiae regulate the expression of genes involved in iron homeostasis.	Iron	115-119	Aft2p	Saccharomyces cerevisiae S288C	35-39
16648636-3	2006	Iron inhibition of Aft1/Aft2 was previously shown to be dependent on mitochondrial components required for cytosolic iron sulfur protein biogenesis.	Iron	0-4	Aft2p	Saccharomyces cerevisiae S288C	24-28
16682004-0	2006	Serum non-transferrin-bound iron and low-density lipoprotein oxidation in heterozygous hemochromatosis.	Iron	28-32	transferrin	Homo sapiens	10-21
16648636-4	2006	We presently show that the nuclear monothiol glutaredoxins Grx3 and Grx4 are critical for iron inhibition of Aft1 in yeast cells.	Iron	90-94	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	68-72
16648636-10	2006	Thus, Grx3 and Grx4 are novel components required for Aft1 iron regulation that most likely occurs in the nucleus.	Iron	59-63	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	15-19
16682004-1	2006	UNLABELLED: Non-transferrin-bound iron (NTBI) is implicated in lipid peroxidation but the relation with oxidative modification of low-density lipoprotein (LDL) is not known.	Iron	34-38	transferrin	Homo sapiens	16-27
16603772-0	2006	Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	147-151
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	89-91	cytochrome p450 oxidoreductase	Homo sapiens	36-39
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	141-143	cytochrome p450 oxidoreductase	Homo sapiens	36-39
16603772-0	2006	Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.	Iron	82-86	iron-sulfur cluster assembly enzyme	Homo sapiens	147-151
16775270-1	2006	BACKGROUND AND OBJECTIVE: Patients with a clinical diagnosis of neurodegeneration with brain iron accumulation (NBIA, formerly called Hallervorden-Spatz syndrome) often have mutations in PANK2, the gene encoding pantothenate kinase 2.	Iron	93-97	pantothenate kinase 2	Homo sapiens	187-192
16731299-0	2006	Association between transferrin receptor-ferritin index and conventional measures of iron responsiveness in hemodialysis patients.	Iron	85-89	transferrin	Homo sapiens	20-31
16731299-1	2006	BACKGROUND: The diagnostic power of the transferrin receptor-ferritin (TfR-F) index for identification of iron responsiveness in long-term hemodialysis (HD) patients compared with the routine markers recommended by the current US and European guidelines was appraised.	Iron	106-110	transferrin	Homo sapiens	40-51
16781229-0	2006	Comparison of the serum ferritin and percentage of transferrin saturation as exposure markers of iron-driven oxidative stress-related disease outcomes.	Iron	97-101	transferrin	Homo sapiens	51-62
16460863-0	2006	The influence of gallium and other metal ions on the uptake of non-transferrin-bound iron by rat hepatocytes.	Iron	85-89	transferrin	Rattus norvegicus	67-78
16460863-1	2006	BACKGROUND: Under conditions of iron overload non-transferrin-bound iron (NTBI) occurs in the circulation and is mainly cleared by the liver.	Iron	68-72	transferrin	Rattus norvegicus	50-61
16644088-4	2006	Whereas the first could also be generated with nitrofurantoin, the stimulation of non-transferrin-bound iron uptake was only seen with antimycin A and needed considerably higher concentrations.	Iron	104-108	transferrin	Homo sapiens	86-97
16644088-6	2006	Depletion with iron chelators before or after treatment with antimycin A diminished the stimulation of non-transferrin-bound iron uptake.	Iron	15-19	transferrin	Homo sapiens	107-118
16460863-9	2006	In iron-loaded cells, inhibition of NTBI uptake by diferric transferrin completely disappeared within 2 hours.	Iron	3-7	transferrin	Rattus norvegicus	60-71
16644088-6	2006	Depletion with iron chelators before or after treatment with antimycin A diminished the stimulation of non-transferrin-bound iron uptake.	Iron	125-129	transferrin	Homo sapiens	107-118
16644088-8	2006	But high concentrations of antimycin A leading to the stimulation of non-transferrin-bound iron uptake is possibly not related to the inhibition of the respiratory chain.	Iron	91-95	transferrin	Homo sapiens	73-84
16850686-8	2006	These results demonstrate that estrogen enhances the inhibitory effect of iron on microglial NO production by decreasing mRNA expression of iNOS and also suggest that iron sequestration by microglia under neuropathological conditions could be a protective mechanism against NO-induced neurotoxicity.	Iron	74-78	nitric oxide synthase 2	Rattus norvegicus	140-144
16732023-1	2006	OBJECTIVE: Epidemiological studies suggest that high body iron stores are associated with insulin resistance and type 2 diabetes.	Iron	58-62	insulin	Homo sapiens	90-97
16458294-2	2006	Uptake of iron is critical for E. histolytica growth and iron-bound human transferrin (holo-transferrin) has been shown to serve as an iron source in vitro.	Iron	57-61	transferrin	Homo sapiens	74-85
16458294-2	2006	Uptake of iron is critical for E. histolytica growth and iron-bound human transferrin (holo-transferrin) has been shown to serve as an iron source in vitro.	Iron	57-61	transferrin	Homo sapiens	92-103
16458294-2	2006	Uptake of iron is critical for E. histolytica growth and iron-bound human transferrin (holo-transferrin) has been shown to serve as an iron source in vitro.	Iron	57-61	transferrin	Homo sapiens	74-85
16458294-2	2006	Uptake of iron is critical for E. histolytica growth and iron-bound human transferrin (holo-transferrin) has been shown to serve as an iron source in vitro.	Iron	57-61	transferrin	Homo sapiens	92-103
16458294-3	2006	Although a transferrin-binding protein has been identified in E. histolytica, the mechanism by which this iron source is taken up by this pathogen is not well understood.	Iron	106-110	transferrin	Homo sapiens	11-22
17325962-12	2006	On the other hand, osteocalcin level was significantly lower in patients than controls (p = 0.011), and this may be due to osteoblast poisoning by iron overload.	Iron	147-151	bone gamma-carboxyglutamate protein	Homo sapiens	19-30
16680451-2	2006	We have studied the effect of the modulation of SOD1 levels on iron metabolism in a cultured human glial cell line and in a mouse motoneuronal cell line.	Iron	63-67	superoxide dismutase 1	Homo sapiens	48-52
16680451-5	2006	We propose that changes in superoxide levels due to alteration of SOD1 activity affect iron metabolism in glial and neuronal cells from higher eukaryotes and that this may be relevant to diseases of the nervous system.	Iron	87-91	superoxide dismutase 1	Homo sapiens	66-70
16936796-1	2006	Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family.	Iron	18-22	transferrin	Homo sapiens	64-75
16936804-0	2006	Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life.	Iron	94-98	intelectin 1 (galactofuranose binding)	Mus musculus	21-41
16936804-1	2006	It has been proposed that lactoferrin receptor (LfR) may be involved in intestinal iron transport during early life.	Iron	83-87	intelectin 1 (galactofuranose binding)	Mus musculus	26-46
16936804-1	2006	It has been proposed that lactoferrin receptor (LfR) may be involved in intestinal iron transport during early life.	Iron	83-87	intelectin 1 (galactofuranose binding)	Mus musculus	48-51
16936804-3	2006	To address the hypothesis that LfR may play a role as an alternative iron transport pathway during early life, we used immunohistochemistry (IHC) to examine the localization of mouse LfR (mLfR) and DMT1.	Iron	69-73	intelectin 1 (galactofuranose binding)	Mus musculus	31-34
16936804-13	2006	The immunolocalization and abundant protein expression of mLfR suggest that accrual of iron from Lf may be the principal iron uptake pathway at this age.	Iron	87-91	intelectin 1 (galactofuranose binding)	Mus musculus	58-62
16936804-13	2006	The immunolocalization and abundant protein expression of mLfR suggest that accrual of iron from Lf may be the principal iron uptake pathway at this age.	Iron	121-125	intelectin 1 (galactofuranose binding)	Mus musculus	58-62
16936804-14	2006	In conclusion, our findings support the notion that until the development-dependent expression of DMT1 in the intestine is induced, mLfR may serve as an alternative iron uptake pathway.	Iron	165-169	intelectin 1 (galactofuranose binding)	Mus musculus	132-136
16460831-0	2006	Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes.	Iron	46-50	GLI family zinc finger 2	Homo sapiens	75-79
16460831-7	2006	Importantly, hepcidin expression from Huh7 cells elicited a decrease in the levels of the iron-sensitive post-transcriptional regulator IRP2 in THP1 cells, accompanied by de novo synthesis of the iron storage protein ferritin.	Iron	90-94	iron responsive element binding protein 2	Homo sapiens	136-140
16460831-7	2006	Importantly, hepcidin expression from Huh7 cells elicited a decrease in the levels of the iron-sensitive post-transcriptional regulator IRP2 in THP1 cells, accompanied by de novo synthesis of the iron storage protein ferritin.	Iron	90-94	GLI family zinc finger 2	Homo sapiens	144-148
16850686-8	2006	These results demonstrate that estrogen enhances the inhibitory effect of iron on microglial NO production by decreasing mRNA expression of iNOS and also suggest that iron sequestration by microglia under neuropathological conditions could be a protective mechanism against NO-induced neurotoxicity.	Iron	167-171	nitric oxide synthase 2	Rattus norvegicus	140-144
15993987-3	2006	Moreover, Fe(2+) induced lysosomal accumulation of endogenous Abeta and APOE in cultured cells, and Abeta deposition in vascular tunica media in organotypic cultures of brain vessels.	Iron	10-12	amyloid beta precursor protein	Homo sapiens	62-67
15993987-3	2006	Moreover, Fe(2+) induced lysosomal accumulation of endogenous Abeta and APOE in cultured cells, and Abeta deposition in vascular tunica media in organotypic cultures of brain vessels.	Iron	10-12	apolipoprotein E	Homo sapiens	72-76
15993987-7	2006	We hypothesize that locally increased concentrations of iron induce accumulation of exogenous and endogenous Abeta in SMCs, triggering beta-amyloid angiopathy.	Iron	56-60	amyloid beta precursor protein	Homo sapiens	109-114
16800926-1	2006	This study was purposed to observe the changes of caspase-3 activity during apoptosis of HL-60 cells induced by an iron chelator, DFO (deferoxamine), and to explore the mechanism underlying apoptosis in HL-60 cells.	Iron	115-119	caspase 3	Homo sapiens	50-59
16871764-14	2006	It is readily identified through biochemical testing for iron overload using serum transferrin saturation and genetic testing for C282Y homozygosity.	Iron	57-61	transferrin	Homo sapiens	83-94
16700545-2	2006	The CYP3A4 isoform is inhibited by antifungal imidazoles or triazoles, which form low-spin heme iron complexes via formation of a nitrogen-ferric iron coordinate bond.	Iron	96-100	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	4-10
16678819-2	2006	Here, we demonstrate that the transient interaction between soluble cytochrome c(6) and membrane-embedded photosystem I involves subtle changes in the heme iron, as inferred by X-ray absorption spectroscopy (XAS).	Iron	156-160	cytochrome c, somatic	Homo sapiens	68-80
16679408-11	2006	Collectively, NO stimulates Fe and GSH efflux from cells via MRP1.	Iron	28-30	ATP binding cassette subfamily C member 1	Homo sapiens	61-65
16564538-0	2006	The mechanism of iron release from the transferrin-receptor 1 adduct.	Iron	17-21	transferrin	Homo sapiens	39-50
16707465-6	2006	Interestingly, DATS-mediated degradation of ferritin, increase in labile iron pool, ROS generation, and/or cell cycle arrest were significantly attenuated by ectopic expression of a catalytically inactive mutant of JNK kinase 2 and RNA interference of stress-activated protein kinase/extracellular signal-regulated kinase 1 (SEK1), upstream kinases in JNK signal transduction pathway.	Iron	73-77	mitogen-activated protein kinase 8	Homo sapiens	215-218
16679408-0	2006	Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1.	Iron	32-36	ATP binding cassette subfamily C member 1	Homo sapiens	103-144
16679408-3	2006	Hence, we studied the role of the GSH-conjugate transporter multidrug resistance-associated protein 1 (MRP1) in NO-mediated Fe efflux.	Iron	124-126	ATP binding cassette subfamily C member 1	Homo sapiens	60-101
16679408-3	2006	Hence, we studied the role of the GSH-conjugate transporter multidrug resistance-associated protein 1 (MRP1) in NO-mediated Fe efflux.	Iron	124-126	ATP binding cassette subfamily C member 1	Homo sapiens	103-107
16564538-1	2006	We report the determination in cell-free assays of the mechanism of iron release from the N-lobe and C-lobe of human serum transferrin in interaction with intact transferrin receptor 1 at 4.3&lt; or =pH&lt; or =6.5.	Iron	68-72	transferrin	Homo sapiens	123-134
16564538-1	2006	We report the determination in cell-free assays of the mechanism of iron release from the N-lobe and C-lobe of human serum transferrin in interaction with intact transferrin receptor 1 at 4.3&lt; or =pH&lt; or =6.5.	Iron	68-72	transferrin	Homo sapiens	162-173
16634644-4	2006	The nu(Fe)(-)(CO) mode was upshifted from 477 to 485 and to 490 cm(-)(1) by the binding of androstenedione and 19-aldehyde-androstenedione, substrates for the first and third steps, respectively, whereas nu(Fe)(-)(CO) was not observed for P450arom with 19-hydroxyandrostenedione, a substrate for the second step, indicating that the heme distal site is very flexible and changes its structure depending on the substrate.	Iron	7-9	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	239-247
16676031-2	2006	The experimental results show that a binary data page of 18x17 bits is recorded successfully at intervals of 4 mum in a Fe:LiNbO3 crystal with a thickness of 0.5 mm when six data pages are superimposed.	Iron	120-122	latexin	Homo sapiens	111-114
16527810-0	2006	Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.	Iron	92-96	iron-sulfur cluster assembly enzyme	Homo sapiens	83-87
16527810-9	2006	When incubated with iron regulatory protein 1, cysteine, and iron, the cytosolic forms of ISCS and ISCU facilitated efficient formation of a [4Fe-4S] cluster on IRP1.	Iron	20-24	iron-sulfur cluster assembly enzyme	Homo sapiens	99-103
16527810-10	2006	Thus, the cytosolic form of ISCS is a functional cysteine desulfurase that can collaborate with cytosolic ISCU to promote de novo iron-sulfur cluster formation.	Iron	130-134	iron-sulfur cluster assembly enzyme	Homo sapiens	106-110
16448386-0	2006	Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo.	Iron	60-64	ferritin mitochondrial	Mus musculus	30-40
16672462-0	2006	Metal reduction and iron biomineralization by a psychrotolerant Fe(III)-reducing bacterium, Shewanella sp.	Iron	20-24	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	67-70
16625280-0	2006	Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells.	Iron	22-26	aconitase 2	Homo sapiens	36-59
16678014-5	2006	The contribution of transferrin, ceruloplasmin, and albumin concentrations to the iron-binding antioxidant capacity was lost in diabetes (explaining only 4.2 and 6.3% of the variance in type 1 and type 2 diabetes versus 13.9% in control subjects).	Iron	82-86	transferrin	Homo sapiens	20-31
16431112-1	2006	Based on computer modeling of the active site of nitric oxide synthases (NOS), a series of 10 amidine compounds (9-18) was designed including potential inhibitors that involve the coordination of side-chain functional groups with the iron of the heme cofactor.	Iron	234-238	nitric oxide synthase 2	Homo sapiens	49-71
16448386-12	2006	increase in transferrin receptor, indicating that overexpression of FerH is sufficient to elicit a phenotype of iron depletion.	Iron	112-116	ferritin mitochondrial	Mus musculus	68-72
16448386-13	2006	These results demonstrate that FerH not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance.	Iron	75-79	ferritin mitochondrial	Mus musculus	31-35
16448386-13	2006	These results demonstrate that FerH not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance.	Iron	141-145	ferritin mitochondrial	Mus musculus	31-35
16644642-0	2006	Common presence of non-transferrin-bound iron among patients with type 2 diabetes.	Iron	41-45	transferrin	Homo sapiens	23-34
16619132-15	2006	Two of the up-regulated genes, ferritin and transferrin, are indirectly associated with apoptosis through their ability to sequester iron and reduce free radical formation.	Iron	133-137	transferrin	Homo sapiens	44-55
16597321-0	2006	Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV.	Iron	0-4	haptoglobin	Homo sapiens	78-89
16597321-0	2006	Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV.	Iron	0-4	solute carrier family 11 member 1	Homo sapiens	94-100
16597321-0	2006	Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV.	Iron	0-4	solute carrier family 11 member 1	Homo sapiens	102-109
16597321-6	2006	We then examine the putative role of iron-related host genes by focussing on two candidate genes, haptoglobin and NRAMP1, for which there are common polymorphic variants in humans with strong evidence of functionally distinct biochemical phenotypes that would be predicted to influence the course of HIV and TB infections.	Iron	37-41	haptoglobin	Homo sapiens	98-109
16597321-6	2006	We then examine the putative role of iron-related host genes by focussing on two candidate genes, haptoglobin and NRAMP1, for which there are common polymorphic variants in humans with strong evidence of functionally distinct biochemical phenotypes that would be predicted to influence the course of HIV and TB infections.	Iron	37-41	solute carrier family 11 member 1	Homo sapiens	114-120
19002892-0	2006	Evaluation of recombinant human transferrin (DeltaFerrin(TM)) as an iron chelator in serum-free media for mammalian cell culture.	Iron	68-72	transferrin	Homo sapiens	32-43
19002892-6	2006	As such, this is the first report of a recombinant human transferrin produced under animal-free conditions that can act as a universal iron chelator for cells grown in serum-free media (SFM).	Iron	135-139	transferrin	Homo sapiens	57-68
16644642-2	2006	Because vitamin C may cause oxidative stress in the presence of redox active iron, we hypothesized that non-transferrin-bound iron (NTBI), a form of iron susceptible to redox activity, may be present in patients with type 2 diabetes.	Iron	126-130	transferrin	Homo sapiens	108-119
16644642-2	2006	Because vitamin C may cause oxidative stress in the presence of redox active iron, we hypothesized that non-transferrin-bound iron (NTBI), a form of iron susceptible to redox activity, may be present in patients with type 2 diabetes.	Iron	126-130	transferrin	Homo sapiens	108-119
16647565-9	2006	We also found that +/+ and hbd reticulocytes take up free, ferrous iron at identical rates, while the rates of Tf internalization and externalization were significantly decreased in the mutant cells.	Iron	59-71	exocyst complex component 6	Mus musculus	27-30
16830701-8	2006	iron prevents the recurrence of iron deficiency, enhances response to recombinant human erythropoietin therapy, minimizes fluctuation of hemoglobin levels, hematocrit levels, and iron stores, and may reduce overall costs of care.	Iron	0-4	erythropoietin	Homo sapiens	88-102
16133010-6	2006	RESULTS: The DSS+iron group showed a significant increase in inflammatory scores, MPO, TNF-alpha, IL-1, LPO and NF-kappaB activity compared to DSS or DSS+vitamin E.	Iron	17-21	tumor necrosis factor	Rattus norvegicus	87-96
16133010-7	2006	The addition of vitamin E to iron (DSS+iron+vitamin E group) significantly reduced the inflammatory scores, TNF-alpha and IL-6.	Iron	29-33	tumor necrosis factor	Rattus norvegicus	108-117
16133010-7	2006	The addition of vitamin E to iron (DSS+iron+vitamin E group) significantly reduced the inflammatory scores, TNF-alpha and IL-6.	Iron	29-33	interleukin 6	Rattus norvegicus	122-126
16133010-7	2006	The addition of vitamin E to iron (DSS+iron+vitamin E group) significantly reduced the inflammatory scores, TNF-alpha and IL-6.	Iron	39-43	tumor necrosis factor	Rattus norvegicus	108-117
16133010-7	2006	The addition of vitamin E to iron (DSS+iron+vitamin E group) significantly reduced the inflammatory scores, TNF-alpha and IL-6.	Iron	39-43	interleukin 6	Rattus norvegicus	122-126
16640825-3	2006	To counteract potential iron damage, hosts employ the iron chelators, transferrin and lactoferrin.	Iron	24-28	transferrin	Homo sapiens	70-81
16728372-1	2006	It was hypothesized that relative mass relationships among select constituent metals and iron (Fe3+) govern the pulmonary immunotoxic potential of any PM(2.5) sample, as these determine the extent to which Fe3+ binding by transferrin is affected (resulting in altered alveolar macrophage [AM] Fe status and subsequent antibacterial function).	Iron	95-97	transferrin	Rattus norvegicus	222-233
16647565-7	2006	RESULTS: Compared to controls, iron and transferrin uptake as well as iron incorporation into heme was compromised in hbd reticulocytes.	Iron	31-35	exocyst complex component 6	Mus musculus	118-121
16647565-7	2006	RESULTS: Compared to controls, iron and transferrin uptake as well as iron incorporation into heme was compromised in hbd reticulocytes.	Iron	70-74	exocyst complex component 6	Mus musculus	118-121
16632111-0	2006	Iron chelator induces THP-1 cell differentiation potentially by modulating intracellular glutathione levels.	Iron	0-4	GLI family zinc finger 2	Homo sapiens	22-27
16735760-5	2006	Fasting plasma insulin levels were significantly higher in cases than controls (P = 0.004), and correlated well with indicators of iron overload like total units of blood transfused (r = 0.41, P = 0.03), serum ferritin (r = 0.38, P = 0.038) and splenic size (r = 0.43, P = 0.03).	Iron	131-135	insulin	Homo sapiens	15-22
16735760-12	2006	Insulin resistance, compensated by hyperinsulinemia, sets in early even before the onset of frank diabetes mellitus and correlated well with age, chelation therapy and indicators of iron overload like total units of blood transfused, splenomegaly and serum ferritin.	Iron	182-186	insulin	Homo sapiens	0-7
16639025-0	2006	The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration.	Iron	4-8	transferrin	Homo sapiens	17-28
16614402-6	2006	Negative effects of Zn supplementation on Fe absorption were associated with increased small intestine Fe retention, decreased hephaestin, and increased FPN expression.	Iron	42-44	solute carrier family 40 member 1	Rattus norvegicus	153-156
16439612-0	2006	Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells.	Iron	0-4	heme oxygenase 1	Mus musculus	53-69
16702015-0	2006	Is the reactive oxygen species-dependent-NF-kappaB activation observed in iron-loaded BALB/c mice a key process preventing growth of Leishmania major progeny and tissue-damage?	Iron	74-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	41-50
16702015-6	2006	These results show a putative role of an iron-induced reactive oxygen species-dependent activation of NF-kappaB in the development of protective immunity against L. major.	Iron	41-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111
16450344-0	2006	Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.	Iron	121-125	pantothenate kinase 2	Homo sapiens	19-40
16439612-4	2006	We tested our hypothesis that iron may contribute more to the SNP induction of HO-1 than does NO by comparing the HO-1 protein level and the production of NO in RAW 264.7 cells treated with SNP and S-nitroso-N-acetyl-DL-penicillamine (SNAP).	Iron	30-34	heme oxygenase 1	Mus musculus	79-83
16439612-8	2006	Exogenous iron (ferric ammonium citrate or ferricyanide) and forskolin increased the level of HO-1, which was inhibited by PKA inhibitor N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89).	Iron	10-14	heme oxygenase 1	Mus musculus	94-98
16439612-9	2006	These results indicate that iron and cAMP, but not cGMP, play crucial roles in the induction of HO-1 in RAW 264.7 cells.	Iron	28-32	heme oxygenase 1	Mus musculus	96-100
16439612-11	2006	This study illustrates that iron rather than NO from SNP contributes to HO-1 induction.	Iron	28-32	heme oxygenase 1	Mus musculus	72-76
16439612-13	2006	We concluded that iron released by SNP contributes to HO-1 induction via the cAMP-PKA-mitogen-activated protein kinase pathway.	Iron	18-22	heme oxygenase 1	Mus musculus	54-58
16565871-7	2006	Iron supplementation was prescribed to maintain ferritin levels&gt;100 microg/l and transferrin saturation levels&gt;20%.	Iron	0-4	transferrin	Homo sapiens	84-95
16527254-0	2006	Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway.	Iron	20-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
16637741-3	2006	Haptoglobin polymorphisms result in proteins with altered haemoglobin-binding capacity and different antioxidant, iron-recycling, and immune functions.	Iron	114-118	haptoglobin	Homo sapiens	0-11
16637741-12	2006	CONCLUSIONS: The finding that haptoglobin 2-2 genotype is a risk factor for anaemia in children in a malaria-endemic area may reflect the reduced ability of the Hp2-2 polymer to scavenge free haemoglobin-iron following malaria-induced haemolysis.	Iron	204-208	haptoglobin	Homo sapiens	30-41
16527254-7	2006	This result suggested that the iron chelating function of DFX was important to induce the increase of COX-2 and HIF-1alpha protein.	Iron	31-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-107
16527254-7	2006	This result suggested that the iron chelating function of DFX was important to induce the increase of COX-2 and HIF-1alpha protein.	Iron	31-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
16527254-10	2006	Together, our findings suggest that iron metabolism may regulate stabilization of HIF-1alpha protein by modulating cyclooxygenase-2 signaling pathway.	Iron	36-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
16527254-10	2006	Together, our findings suggest that iron metabolism may regulate stabilization of HIF-1alpha protein by modulating cyclooxygenase-2 signaling pathway.	Iron	36-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	115-131
16529768-1	2006	Transferrin constitutes the major protein involved in the transport of iron from the sites of absorption to the sites of storage and utilization.	Iron	71-75	transferrin	Homo sapiens	0-11
16618820-0	2006	Non-transferrin-bound iron and risk of coronary heart disease in postmenopausal women.	Iron	22-26	transferrin	Homo sapiens	4-15
16618820-2	2006	We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might be more suitable for establishing correlations with CHD.	Iron	30-34	transferrin	Homo sapiens	65-76
16618820-2	2006	We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might be more suitable for establishing correlations with CHD.	Iron	83-87	transferrin	Homo sapiens	65-76
16618820-2	2006	We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might be more suitable for establishing correlations with CHD.	Iron	83-87	transferrin	Homo sapiens	65-76
16529768-2	2006	Despite the high affinity of transferrin for iron, most bacterial pathogens, such as the human restricted Neisseria meningitidis, have developed iron acquisition mechanisms.	Iron	45-49	transferrin	Homo sapiens	29-40
16630378-8	2006	Among the iron-related parameters investigated in the patients, only total iron-binding capacity and the serum concentration of haptoglobin differed significantly with haptoglobin phenotype.	Iron	10-14	haptoglobin	Homo sapiens	168-179
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	26-30	Mtm1p	Saccharomyces cerevisiae S288C	161-165
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	26-30	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	167-171
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	26-30	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	176-180
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	Mtm1p	Saccharomyces cerevisiae S288C	161-165
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	167-171
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	176-180
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	Mtm1p	Saccharomyces cerevisiae S288C	161-165
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	167-171
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	176-180
16601688-5	2006	Studies in mtm1 mutants indicate that iron inactivation of SOD2 involves the Mrs3p/Mrs4p mitochondrial carriers and iron-binding frataxin (Yfh1p).	Iron	38-42	Mtm1p	Saccharomyces cerevisiae S288C	11-15
16566929-0	2006	Prokaryotic and eukaryotic monothiol glutaredoxins are able to perform the functions of Grx5 in the biogenesis of Fe/S clusters in yeast mitochondria.	Iron	114-116	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	88-92
16566929-1	2006	The Saccharomyces cerevisiae monothiol glutaredoxin Grx5 participates in the mitochondrial biogenesis of iron-sulfur clusters.	Iron	105-109	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	52-56
16605268-9	2006	This catalytic activity correlated with partial unfolding of cyt c monitored by Trp(59) fluorescence and absorbance at 695 nm (Fe-S(Met(80)) band).	Iron	127-131	cytochrome c, somatic	Homo sapiens	61-66
16630378-8	2006	Among the iron-related parameters investigated in the patients, only total iron-binding capacity and the serum concentration of haptoglobin differed significantly with haptoglobin phenotype.	Iron	75-79	haptoglobin	Homo sapiens	168-179
16291590-0	2006	Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo.	Iron	29-33	melanotransferrin	Mus musculus	8-25
16595935-0	2006	Proteases of a Bacillus subtilis clinical isolate facilitate swarming and siderophore-mediated iron uptake via proteolytic cleavage of transferrin.	Iron	95-99	transferrin	Homo sapiens	135-146
16595935-3	2006	The growth of PRY was in proportion to increased iron availability resulting from transferrin destruction.	Iron	49-53	PTPN13 like Y-linked	Homo sapiens	14-17
16595935-3	2006	The growth of PRY was in proportion to increased iron availability resulting from transferrin destruction.	Iron	49-53	transferrin	Homo sapiens	82-93
16595935-4	2006	These results suggest that proteases of the B. subtilis PRY strain may play a significant role in the pathogenesis of human infections by facilitating siderophore-mediated iron uptake from transferrin and swarming motility.	Iron	172-176	PTPN13 like Y-linked	Homo sapiens	56-59
16595935-4	2006	These results suggest that proteases of the B. subtilis PRY strain may play a significant role in the pathogenesis of human infections by facilitating siderophore-mediated iron uptake from transferrin and swarming motility.	Iron	172-176	transferrin	Homo sapiens	189-200
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	85-89	melanotransferrin	Mus musculus	0-17
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	85-89	melanotransferrin	Mus musculus	19-22
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	91-93	melanotransferrin	Mus musculus	0-17
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	91-93	melanotransferrin	Mus musculus	19-22
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	174-176	melanotransferrin	Mus musculus	0-17
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	174-176	melanotransferrin	Mus musculus	19-22
16291590-2	2006	Considering the vital role of Fe in many metabolic pathways, such as DNA and heme synthesis, it is important to understand the function of MTf.	Iron	30-32	melanotransferrin	Mus musculus	139-142
16545687-5	2006	The objective was to show that iron overload in HFE-related hemochromatosis is associated with increased oxidative stress assessed through 8-iso-PGF(2alpha) urinary excretion, and that oxidative stress is impacted by iron-removal treatment (phlebotomy).	Iron	31-35	placental growth factor	Homo sapiens	145-148
16415110-6	2006	Despite these differences in metabolism, all four ITZ stereoisomers induced a type II binding spectrum with CYP3A4, characteristic of coordination of the triazole nitrogen to the heme iron (K(s) 2.2-10.6 nM).	Iron	184-188	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
16340950-7	2006	After the intervention, there was a significant increase in ferritin and transferrin saturation in the iron+iodine group (17.6 vs 8.7 microg/dl, and 18.8 vs 7.2%, respectively, P&lt;0.001 for both) and in the iron group (P&lt;0.001 for both).	Iron	103-107	transferrin	Homo sapiens	73-84
16553865-0	2006	Effect of the crp mutation on the utilization of transferrin-bound iron by Vibrio vulnificus.	Iron	67-71	C-reactive protein	Homo sapiens	14-17
16553865-5	2006	Moreover, the crp mutant could not utilize transferrin-bound iron, and its growth was severely suppressed both on transferrin-bound iron and in cirrhotic ascites.	Iron	61-65	C-reactive protein	Homo sapiens	14-17
16553865-2	2006	We found that growth retardation of V. vulnificus caused by mutation of the crp gene encoding CRP was exacerbated under iron-limited conditions.	Iron	120-124	C-reactive protein	Homo sapiens	76-79
16553865-2	2006	We found that growth retardation of V. vulnificus caused by mutation of the crp gene encoding CRP was exacerbated under iron-limited conditions.	Iron	120-124	C-reactive protein	Homo sapiens	94-97
16553865-3	2006	Accordingly, we investigated the effect of crp mutation on the expression of the vulnibactin-mediated iron-uptake system and the ability of V. vulnificus to utilize transferrin-bound iron, and thus to grow in cirrhotic ascites, a human ex vivo system.	Iron	102-106	C-reactive protein	Homo sapiens	43-46
16553865-5	2006	Moreover, the crp mutant could not utilize transferrin-bound iron, and its growth was severely suppressed both on transferrin-bound iron and in cirrhotic ascites.	Iron	132-136	C-reactive protein	Homo sapiens	14-17
16553865-8	2006	These results indicate that crp mutation attenuates the ability to grow on transferrin-bound iron and in a human body fluid by down-regulating the vulnibactin-mediated iron-uptake system.	Iron	93-97	C-reactive protein	Homo sapiens	28-31
16553865-8	2006	These results indicate that crp mutation attenuates the ability to grow on transferrin-bound iron and in a human body fluid by down-regulating the vulnibactin-mediated iron-uptake system.	Iron	168-172	C-reactive protein	Homo sapiens	28-31
16672262-1	2006	Tyrosine hydroxylase (TH), an iron-containing enzyme, catalyzes the first and rate-limiting step of catecholamine biosynthesis, and requires tetrahydrobiopterin (BH4) as a cofactor.	Iron	30-34	tyrosine hydroxylase	Homo sapiens	0-20
16539659-0	2006	Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer"s disease.	Iron	13-17	amyloid beta precursor protein	Homo sapiens	28-53
16539659-1	2006	Brain iron dysregulation and its association with amyloid precursor protein (APP) plaque formation are implicated in Alzheimer"s disease (AD) pathology and so iron chelation could be considered a rational therapeutic strategy for AD.	Iron	6-10	amyloid beta precursor protein	Homo sapiens	50-75
16384825-9	2006	At multiple linear regression analysis, haemoglobin, BMI, albumin, CRP and serum iron levels were independently associated with the natural logarithm of the weekly EPO dose (R(2) = 0.22).	Iron	81-85	erythropoietin	Homo sapiens	164-167
16174659-7	2006	Of 59 relatives homozygous for C282Y, 76% of men and 32% of women had the "iron phenotype" (raised transferrin saturation and serum ferritin).	Iron	75-79	transferrin	Homo sapiens	99-110
16467964-2	2006	The cleavage results in the release of iron, a regulator of transferrin, ferritin, and nitric oxide (NO) synthase gene expression.	Iron	39-43	transferrin	Rattus norvegicus	60-71
16520948-1	2006	Intravenous iron therapy is recommended for children and adults who receive hemodialysis (HD) and recombinant human erythropoietin (rHuEPO).	Iron	12-16	erythropoietin	Homo sapiens	116-130
16418170-1	2006	Recent positional cloning of the radiation-induced polycythaemia (Pcm) mutation revealed a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), the sole cellular iron exporter identified to date.	Iron	177-181	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	137-150
16455656-0	2006	CpSufE activates the cysteine desulfurase CpNifS for chloroplastic Fe-S cluster formation.	Iron	67-71	chloroplast sulfur E	Arabidopsis thaliana	0-6
16455656-11	2006	The iron-sulfur cluster reconstitution activity of the CpNifS-CpSufE complex toward apoferredoxin was 20-fold higher than that of CpNifS alone.	Iron	4-8	chloroplast sulfur E	Arabidopsis thaliana	62-68
16431909-1	2006	The specialized yeast mitochondrial chaperone system, composed of the Hsp70 Ssq1p, its co-chaperone J-protein Jac1p, and the nucleotide release factor Mge1p, perform a critical function in the biogenesis of iron-sulfur (Fe/S) proteins.	Iron	220-222	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	76-81
16455656-12	2006	We conclude that CpNifS and CpSufE together form a cysteine desulfurase required for iron-sulfur cluster formation in chloroplasts.	Iron	85-89	chloroplast sulfur E	Arabidopsis thaliana	28-34
16418170-1	2006	Recent positional cloning of the radiation-induced polycythaemia (Pcm) mutation revealed a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), the sole cellular iron exporter identified to date.	Iron	177-181	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	152-156
16418170-3	2006	Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age.	Iron	45-49	cytochrome b reductase 1	Mus musculus	82-88
16418170-3	2006	Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age.	Iron	149-153	cytochrome b reductase 1	Mus musculus	82-88
16418170-7	2006	Aged cohorts of Pcm mice exhibited low levels of Fpn1 expression in the context of an iron-deficient erythropoiesis and profound iron sequestration in reticuloendothelial macrophages, duodenum, and other tissues.	Iron	86-90	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	49-53
16377630-6	2006	Other alterations were mainly found in CuZn-SOD knockout mice, such as halved glutathione peroxidase activity in the tissues examined and increased glutathione and iron in the liver.	Iron	164-168	superoxide dismutase 1, soluble	Mus musculus	39-47
16511496-8	2006	Disruption of the yeast mfrn orthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis.	Iron	75-79	Fe(2+) transporter	Saccharomyces cerevisiae S288C	42-46
16412980-3	2006	Biochemical analyses of the MRCKalpha IRE revealed that it was functional and mediated the response to iron level in the same way as transferrin receptor 1 IREs (TfR) did.	Iron	103-107	CDC42 binding protein kinase alpha	Homo sapiens	28-37
16412980-4	2006	Similarly to TfR mRNA, MRCKalpha mRNA is stabilized, when iron supply is low, while it is destabilized under iron-rich conditions.	Iron	58-62	CDC42 binding protein kinase alpha	Homo sapiens	23-32
16412980-6	2006	The level of MRCKalpha mRNA in various tissues strongly positively correlates with the level of TfR mRNA, indicating its possible role in the transferrin iron uptake pathway.	Iron	154-158	CDC42 binding protein kinase alpha	Homo sapiens	13-22
16412980-6	2006	The level of MRCKalpha mRNA in various tissues strongly positively correlates with the level of TfR mRNA, indicating its possible role in the transferrin iron uptake pathway.	Iron	154-158	transferrin	Homo sapiens	142-153
16511496-8	2006	Disruption of the yeast mfrn orthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis.	Iron	109-113	Fe(2+) transporter	Saccharomyces cerevisiae S288C	42-46
16510596-1	2006	Cellular iron is needed for cell survival and hydroxylation of hypoxia-inducible factor-1alpha (HIF-alpha) by prolyl hydroxylases (PHD).	Iron	9-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-94
16677095-4	2006	Presumably as a consequence of the iron-sulfur cluster defect, cytochrome c heme is deficient in mutants, as well as heme-dependent Complex IV.	Iron	35-39	cytochrome c, somatic	Homo sapiens	63-75
16878186-0	2006	Analysis of HFE gene mutations and HLA-A alleles in Brazilian patients with iron overload.	Iron	76-80	major histocompatibility complex, class I, A	Homo sapiens	35-40
16509978-10	2006	Multivariate analysis showed that the combination of the most common HLA-A alleles also have an impact on the clinical expression of HH in terms of iron stores, in males(p = 0.0009).	Iron	148-152	major histocompatibility complex, class I, A	Homo sapiens	69-74
16510578-8	2006	Both the reduction in labile iron pool and the up-regulation of HIF-1alpha were suppressed by RNA interference-mediated down-regulation of the iron transporter natural resistance-associated macrophage protein 1.	Iron	29-33	solute carrier family 11 member 1	Homo sapiens	160-210
16221503-0	2006	Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes.	Iron	90-94	tumor necrosis factor	Rattus norvegicus	22-49
16517407-0	2006	Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis.	Iron	64-68	iron-sulfur cluster assembly enzyme	Homo sapiens	46-50
16517407-0	2006	Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis.	Iron	99-103	iron-sulfur cluster assembly enzyme	Homo sapiens	46-50
16517407-1	2006	Iron-sulfur (Fe-S) clusters are required for the functions of mitochondrial aconitase, mammalian iron regulatory protein 1, and many other proteins in multiple subcellular compartments.	Iron	13-17	aconitase 2	Homo sapiens	62-85
16517407-4	2006	Suppression of human ISCU by RNAi not only inactivated mitochondrial and cytosolic aconitases in a compartment-specific manner but also inappropriately activated the iron regulatory proteins and disrupted intracellular iron homeostasis.	Iron	166-170	iron-sulfur cluster assembly enzyme	Homo sapiens	21-25
16517407-4	2006	Suppression of human ISCU by RNAi not only inactivated mitochondrial and cytosolic aconitases in a compartment-specific manner but also inappropriately activated the iron regulatory proteins and disrupted intracellular iron homeostasis.	Iron	219-223	iron-sulfur cluster assembly enzyme	Homo sapiens	21-25
16517407-5	2006	Furthermore, endogenous ISCU levels were suppressed by iron deprivation.	Iron	55-59	iron-sulfur cluster assembly enzyme	Homo sapiens	24-28
16208485-2	2006	In the liver, HFE is required for appropriate expression of hepcidin, a humoral mediator of iron absorption.	Iron	92-96	hepcidin antimicrobial peptide	Rattus norvegicus	60-68
16256097-3	2006	Haptoglobin (Hp) is a plasma protein participating in iron metabolism.	Iron	54-58	haptoglobin	Homo sapiens	0-11
16256097-5	2006	We investigated the relationship between vitamin C, iron status and haptoglobin polymorphism in Chinese men and women.	Iron	52-56	haptoglobin	Homo sapiens	68-79
16503547-1	2006	BACKGROUND AND OBJECTIVES: The functions of the iron regulatory proteins (IRP1 and IRP2), which control cellular iron homeostasis are similar but not identical.	Iron	48-52	iron responsive element binding protein 2	Homo sapiens	83-87
16503547-1	2006	BACKGROUND AND OBJECTIVES: The functions of the iron regulatory proteins (IRP1 and IRP2), which control cellular iron homeostasis are similar but not identical.	Iron	113-117	iron responsive element binding protein 2	Homo sapiens	83-87
16503547-10	2006	INTERPRETATION AND CONCLUSIONS: These findings of the first extensive investigation of the comparative expression of the two IRP in human tissues and blood cells indicate that IRP2 is the major regulator of intracellular iron homeostasis in humans.	Iron	221-225	iron responsive element binding protein 2	Homo sapiens	176-180
16221503-0	2006	Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes.	Iron	90-94	interleukin 6	Rattus norvegicus	54-67
16221503-0	2006	Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes.	Iron	90-94	hepcidin antimicrobial peptide	Rattus norvegicus	71-75
16221503-1	2006	BACKGROUND/AIMS: To study the effect of iron and proinflammatory cytokines on the expression of HAMP and other iron regulatory genes in primary rat hepatocytes.	Iron	40-44	hepcidin antimicrobial peptide	Rattus norvegicus	96-100
16221503-6	2006	In the presence of serum, tumor necrosis factor-alpha, lipopolysaccharide and interleukin-6 increased HAMP expression in hepatocytes from both control and iron-loaded rats.	Iron	155-159	tumor necrosis factor	Rattus norvegicus	26-53
16476787-3	2006	This low-iron environment is maintained by the unsaturated iron-binding proteins transferrin and lactoferrin, which depend on well-oxygenated tissues, where a relatively high oxidation-reduction potential (Eh) and pH are essential for the binding of ferric iron.	Iron	9-13	transferrin	Homo sapiens	81-92
16221503-6	2006	In the presence of serum, tumor necrosis factor-alpha, lipopolysaccharide and interleukin-6 increased HAMP expression in hepatocytes from both control and iron-loaded rats.	Iron	155-159	interleukin 6	Rattus norvegicus	78-91
16476787-3	2006	This low-iron environment is maintained by the unsaturated iron-binding proteins transferrin and lactoferrin, which depend on well-oxygenated tissues, where a relatively high oxidation-reduction potential (Eh) and pH are essential for the binding of ferric iron.	Iron	17-21	transferrin	Homo sapiens	81-92
16221503-6	2006	In the presence of serum, tumor necrosis factor-alpha, lipopolysaccharide and interleukin-6 increased HAMP expression in hepatocytes from both control and iron-loaded rats.	Iron	155-159	hepcidin antimicrobial peptide	Rattus norvegicus	102-106
16221503-10	2006	CONCLUSIONS: HAMP expression differs in cultured as compared with freshly isolated hepatocytes, and decreases in iron-loaded hepatocytes in serum free-media, suggesting that additional serum factors influence HAMP expression.	Iron	113-117	hepcidin antimicrobial peptide	Rattus norvegicus	209-213
16221503-11	2006	Tumor necrosis factor-alpha regulates the mRNA levels of HAMP, IREG1, DMT1 and TfR2 in cultured hepatocytes from both iron-loaded and control animals.	Iron	118-122	tumor necrosis factor	Rattus norvegicus	0-27
16221503-11	2006	Tumor necrosis factor-alpha regulates the mRNA levels of HAMP, IREG1, DMT1 and TfR2 in cultured hepatocytes from both iron-loaded and control animals.	Iron	118-122	hepcidin antimicrobial peptide	Rattus norvegicus	57-61
16736416-11	2006	The urinary FE of IL-1 was 1.2 +/- 0.6% in NRF, and 1.0 +/- 0.4% in NOARF (ns), the FE of IL-6 was 1.4 +/- 0.8% in NRF and 1.3 +/- 0.3% in NOARF (ns).	Iron	12-14	interleukin 1 beta	Homo sapiens	18-22
16319092-5	2006	This study tested the hypothesis that a sustained PCB-induced HO-1 response leads to abnormally high Fe levels, which generates ROS production and mediates death in the MN9D DAergic cell model.	Iron	101-103	heme oxygenase 1	Mus musculus	62-66
16386335-10	2006	The synaptosomes isolated from gerbil pre-injected with FAEE and subsequently treated with AAPH or Fe(2+)/H(2)O(2) showed induction of heme oxygenase (HO-1) and heat shock protein 70 (HSP-70) but reduced inducible nitric oxide synthase (iNOS) levels.	Iron	99-101	nitric oxide synthase 2	Homo sapiens	204-235
16386335-10	2006	The synaptosomes isolated from gerbil pre-injected with FAEE and subsequently treated with AAPH or Fe(2+)/H(2)O(2) showed induction of heme oxygenase (HO-1) and heat shock protein 70 (HSP-70) but reduced inducible nitric oxide synthase (iNOS) levels.	Iron	99-101	nitric oxide synthase 2	Homo sapiens	237-241
16915754-16	2006	Iron stores should be continuously monitored, particularly in patients receiving rHuEPO, since iron deficiency is an important problem for patients undergoing peritoneal dialysis, especially during erythropoietin therapy.	Iron	0-4	erythropoietin	Homo sapiens	198-212
16437155-7	2006	Our data demonstrate that plastidic and mitochondrial Fe-S cluster biogenesis shares a common, essential component, and that AtSufE acts as an activator of plastidic and mitochondrial desulfurases in Arabidopsis.	Iron	54-58	chloroplast sulfur E	Arabidopsis thaliana	125-131
17100286-3	2006	Expression of HIF-1alpha mRNA also depends on iron because desferrioxamine and cobalt chloride produce similar to hypoxia effects on the levels of this mRNA.	Iron	46-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
16479012-1	2006	In iron-replete cells the posttranscriptional regulator IRP2 undergoes ubiquitination and proteasomal degradation.	Iron	3-7	iron responsive element binding protein 2	Homo sapiens	56-60
16479012-10	2006	Collectively, these results suggest that IRP2 degradation by SNP does not require S nitrosylation but rather represents a response to iron loading.	Iron	134-138	iron responsive element binding protein 2	Homo sapiens	41-45
16475818-4	2006	Isoform II is expressed in many cells and is essential for the acquisiton of transferrin iron from acidified endosomes.	Iron	89-93	transferrin	Homo sapiens	77-88
16239432-6	2006	However, this apparent inappropriate regulation of hepcidin correlated with increased transferrin saturation and levels of diferric transferrin in the plasma, which in turn resulted from the reduced capacity of hbd animals to effectively use transferrin-bound iron.	Iron	260-264	exocyst complex component 6	Mus musculus	211-214
16475826-0	2006	Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity.	Iron	43-47	tyrosine hydroxylase	Homo sapiens	51-71
16475826-4	2006	Anaerobic rapid freeze-quench EPR confirmed that the change in the near-UV absorbance of TyrH upon adding reductant corresponded to iron reduction.	Iron	132-136	tyrosine hydroxylase	Homo sapiens	89-93
16572798-2	2006	Arsenate sorbed to ferrihydrite, a model soil mineral, was used to simulate possible effects on ingestion of soil contaminated with As-(V) sorbed to Fe oxide surfaces.	Iron	149-151	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	132-138
16467537-6	2006	In agreement with these results, mimickers of HO-1 products, such as bilirubin, ferrous iron, and a carbon monoxide-releasing molecule, reduced IFN-gamma-induced iNOS expression and/or NO release.	Iron	88-92	interferon gamma	Homo sapiens	144-153
16467537-6	2006	In agreement with these results, mimickers of HO-1 products, such as bilirubin, ferrous iron, and a carbon monoxide-releasing molecule, reduced IFN-gamma-induced iNOS expression and/or NO release.	Iron	88-92	nitric oxide synthase 2	Homo sapiens	162-166
16325931-4	2006	Here, we demonstrate that the efficacy of the antiviral effect of ART is augmented by co-treatment of HCMV-infected fibroblasts with ferrous iron, i.e. Ferrosanol, and/or the iron transfer-mediating molecule holo-transferrin.	Iron	175-179	transferrin	Homo sapiens	213-224
16437574-0	2006	Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation.	Iron	99-103	pantothenate kinase 2	Homo sapiens	37-42
16319067-0	2006	RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.	Iron	12-16	retinoid isomerohydrolase RPE65	Bos taurus	0-5
16319067-12	2006	Further, two specific iron-staining methods showed that purified RPE65 contains endogenous iron.	Iron	22-26	retinoid isomerohydrolase RPE65	Bos taurus	65-70
16319067-12	2006	Further, two specific iron-staining methods showed that purified RPE65 contains endogenous iron.	Iron	91-95	retinoid isomerohydrolase RPE65	Bos taurus	65-70
16319067-13	2006	Inductively coupled plasma mass spectrometry measurements showed that bovine RPE65 binds iron ion with a stoichiometry of 0.8 +/- 0.1.	Iron	89-93	retinoid isomerohydrolase RPE65	Bos taurus	77-82
16319067-14	2006	These results indicate that RPE65 is an iron-dependent isomerohydrolase in the visual cycle.	Iron	40-44	retinoid isomerohydrolase RPE65	Bos taurus	28-33
16325931-4	2006	Here, we demonstrate that the efficacy of the antiviral effect of ART is augmented by co-treatment of HCMV-infected fibroblasts with ferrous iron, i.e. Ferrosanol, and/or the iron transfer-mediating molecule holo-transferrin.	Iron	141-145	transferrin	Homo sapiens	213-224
16395269-6	2006	Intravenous iron significantly increased transferrin saturation and non-transferrin-bound iron (NTBI) when compared with placebo.	Iron	12-16	transferrin	Homo sapiens	41-52
16139409-2	2006	In the presence of oxygen and iron, proline residues in two degradation domains are modified by HIF-1-prolyl hydroxylases (PHDs), resulting in ubiquitination and degradation of HIF-1alpha.	Iron	30-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	177-187
16139409-3	2006	Since both molecular oxygen and iron are elements required for this hydroxylation process, HIF-1alpha might be unmodified and stable in conditions lacking oxygen or iron.	Iron	32-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
16139409-3	2006	Since both molecular oxygen and iron are elements required for this hydroxylation process, HIF-1alpha might be unmodified and stable in conditions lacking oxygen or iron.	Iron	165-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
16139409-11	2006	The oxygen-dependent HIF-1alpha regulation requiring both proline hydroxylation and lysine acetylation may be more complicated than the iron-dependent regulation requiring only proline hydroxylation.	Iron	136-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
16137675-3	2006	Biodegradation of extravasated hemoglobin (exvHb) and deposition of iron in alveoli occurred at 3-56 h post-exposure and was preceded by LKC degranulation and accumulation of MPO, HO-1, and SOD-1 in HLs.	Iron	68-72	myeloperoxidase	Homo sapiens	175-178
16137675-3	2006	Biodegradation of extravasated hemoglobin (exvHb) and deposition of iron in alveoli occurred at 3-56 h post-exposure and was preceded by LKC degranulation and accumulation of MPO, HO-1, and SOD-1 in HLs.	Iron	68-72	superoxide dismutase 1	Homo sapiens	190-195
16087216-0	2006	Effects of zero-valent iron (Fe0) and temperature on the transformation of DDT and its metabolites in lake sediment.	Iron	23-27	D-dopachrome tautomerase	Homo sapiens	75-78
16087216-0	2006	Effects of zero-valent iron (Fe0) and temperature on the transformation of DDT and its metabolites in lake sediment.	Iron	29-32	D-dopachrome tautomerase	Homo sapiens	75-78
16087216-1	2006	Zero-valent iron improves the transformation of DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] and its metabolites in aged and highly contaminated lake sediment under biotic conditions.	Iron	12-16	D-dopachrome tautomerase	Homo sapiens	48-51
16087216-3	2006	At 22 degrees C and 10 weeks" incubation, the DDT concentration is reduced from 2.75 micromol g(-1) (974 mg kg(-1)) to 0.98 micromol g(-1) (346 mg kg(-1)) and 1.98 micromol g(-1) (702 mg kg(-1)) in samples with and without the addition of iron, respectively.	Iron	239-243	D-dopachrome tautomerase	Homo sapiens	46-49
16087216-6	2006	In the presence of iron, however, DDT is reduced to 1.25 micromol g(-1) (442 mg kg(-1)) within 40 weeks" incubation.	Iron	19-23	D-dopachrome tautomerase	Homo sapiens	34-37
16395269-6	2006	Intravenous iron significantly increased transferrin saturation and non-transferrin-bound iron (NTBI) when compared with placebo.	Iron	12-16	transferrin	Homo sapiens	72-83
16395269-6	2006	Intravenous iron significantly increased transferrin saturation and non-transferrin-bound iron (NTBI) when compared with placebo.	Iron	90-94	transferrin	Homo sapiens	72-83
16380292-2	2006	Now, however, a ligand-independent mechanism of IFNgammaR2 internalization is emerging as a more general way of limiting IFNgamma-STAT1 signaling in T cells, with insulin-like growth factor-1 (IGF-1) and iron as the main players.	Iron	204-208	interferon gamma	Homo sapiens	121-135
16328372-5	2006	In contrast, deletion of the AFT1 and AFT2 transcription factor genes blocked the HU activation of a subset of the Aft regulon and the aft1Delta aft2Delta double mutant was hypersensitive to HU in an iron-suppressible manner.	Iron	200-204	Aft2p	Saccharomyces cerevisiae S288C	38-42
16341089-0	2006	Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins.	Iron	41-45	LYR motif containing 4	Homo sapiens	18-23
16430211-0	2006	The crucial importance of chemistry in the structure-function link: manipulating hydrogen bonding in iron-containing superoxide dismutase.	Iron	101-105	superoxide dismutase 1	Homo sapiens	117-137
16430211-1	2006	Fe-containing superoxide dismutase"s active site Fe is coordinated by a solvent molecule, whose protonation state is coupled to the Fe oxidation state.	Iron	0-2	superoxide dismutase 1	Homo sapiens	14-34
16430211-1	2006	Fe-containing superoxide dismutase"s active site Fe is coordinated by a solvent molecule, whose protonation state is coupled to the Fe oxidation state.	Iron	49-51	superoxide dismutase 1	Homo sapiens	14-34
16430211-1	2006	Fe-containing superoxide dismutase"s active site Fe is coordinated by a solvent molecule, whose protonation state is coupled to the Fe oxidation state.	Iron	49-51	superoxide dismutase 1	Homo sapiens	14-34
16430211-2	2006	Thus, we have proposed that H-bonding between glutamine 69 and this solvent molecule can strongly influence the redox activity of the Fe in superoxide dismutase (SOD).	Iron	134-136	superoxide dismutase 1	Homo sapiens	140-160
16430211-2	2006	Thus, we have proposed that H-bonding between glutamine 69 and this solvent molecule can strongly influence the redox activity of the Fe in superoxide dismutase (SOD).	Iron	134-136	superoxide dismutase 1	Homo sapiens	162-165
16671455-1	2006	Pretreatment with low-dose thrombin attenuates brain edema induced by iron or intracerebral hemorrhage (ICH).	Iron	70-74	coagulation factor II	Rattus norvegicus	27-35
16337024-1	2006	A method for measuring gas entrapment in granular iron (Fe0) was developed and used to estimate the impact of gas production on porosity loss during the treatment of a high NO3- groundwater (up to approximately 10 mM).	Iron	50-54	NBL1, DAN family BMP antagonist	Homo sapiens	173-176
16337024-1	2006	A method for measuring gas entrapment in granular iron (Fe0) was developed and used to estimate the impact of gas production on porosity loss during the treatment of a high NO3- groundwater (up to approximately 10 mM).	Iron	56-59	NBL1, DAN family BMP antagonist	Homo sapiens	173-176
16337024-7	2006	Using the stoichiometric reactions between Fe0 and NO3-, an average corrosion rate of 1.7 mmol kg-1 d-1 was derived for the test granular iron.	Iron	138-142	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
16337024-10	2006	The N-mass balance [e.g., N2g and NH4+ and NO3-] suggests that abiotic reduction of NO3- dominated at the start of Fe0 treatment, whereas N2 production became more important once the microbial activity began.	Iron	115-118	NBL1, DAN family BMP antagonist	Homo sapiens	84-87
16337024-12	2006	We conclude that NO3- suppressed the production of H2(g) by competing with water for Fe0 oxidation, especially at the beginning of water treatment when Fe0 is highly reactive.	Iron	85-88	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
16337024-12	2006	We conclude that NO3- suppressed the production of H2(g) by competing with water for Fe0 oxidation, especially at the beginning of water treatment when Fe0 is highly reactive.	Iron	152-155	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
16951741-8	2006	At this pH, the UV as well as visible spectrum of cytochrome c was changed by nitrite, even in the presence of hydrogen peroxide, probably via the formation of a heme iron-nitric oxide complex.	Iron	167-171	cytochrome c, somatic	Homo sapiens	50-62
16671455-12	2006	Our results demonstrate that thrombin increases brain ceruloplasmin levels and exogenous ceruloplasmin reduces ferrous iron-induced brain edema, suggesting that ceruloplasmin up-regulation may contribute to thrombin-induced brain tolerance to ICH by limiting the injury caused by ferrous iron released from the hematoma.	Iron	111-123	coagulation factor II	Rattus norvegicus	207-215
16433737-12	2006	CONCLUSION: The down-regulation of hepcidin and C/EBPalpha gene expression shown in vivo implies disturbed iron sensing contributing to the hepatosiderosis seen in alcoholic liver disease, possibly by mechanisms involving the IL-6 signaling cascade.	Iron	107-111	CCAAT enhancer binding protein alpha	Homo sapiens	48-58
16629165-5	2006	Its role in iron metabolism was originally proposed because of its ferroxidase activity and because of its ability to stimulate iron loading into apo-transferrin and iron efflux from liver.	Iron	12-16	transferrin	Homo sapiens	150-161
16983949-8	2006	We found serum creatinine, creatinine clearance, urea clearance, urine output, hemoglobin, transferrin saturation, and ferritin all to be statistically significantly different before and after administration of IV iron to the patients.	Iron	214-218	transferrin	Homo sapiens	91-102
16354771-7	2006	How iron is then acquired by transferrin and released into circulation remains an unknown step in this process.	Iron	4-8	transferrin	Homo sapiens	29-40
16321358-2	2006	The imidazole moiety of HBP anchors the compound in the P450(Cam) active site by coordination of the heme iron, thereby insuring that covalent modification occurs in the active site.	Iron	106-110	calmodulin 3	Homo sapiens	56-65
16081760-2	2006	These cells appear to use the same transporter, ferroportin (Slc40a1), to export iron.	Iron	81-85	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	61-68
16809897-0	2006	Non-transferrin-bound iron is associated with enhanced Staphylococcus aureus growth in hemodialysis patients receiving intravenous iron sucrose.	Iron	22-26	transferrin	Homo sapiens	4-15
16629167-2	2006	DMTI also is important in non-transferrin bound iron uptake.	Iron	48-52	transferrin	Homo sapiens	30-41
16629165-5	2006	Its role in iron metabolism was originally proposed because of its ferroxidase activity and because of its ability to stimulate iron loading into apo-transferrin and iron efflux from liver.	Iron	128-132	transferrin	Homo sapiens	150-161
16629165-5	2006	Its role in iron metabolism was originally proposed because of its ferroxidase activity and because of its ability to stimulate iron loading into apo-transferrin and iron efflux from liver.	Iron	128-132	transferrin	Homo sapiens	150-161
16160008-1	2006	Divalent metal transporter 1 (DMT1) mediates apical iron uptake in duodenal enterocytes and iron transfer from the transferrin receptor endosomal cycle into the cytosol in erythroid cells.	Iron	92-96	transferrin	Homo sapiens	115-126
16629179-0	2006	Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells.	Iron	10-14	Eph receptor B1	Rattus norvegicus	45-48
16629179-3	2006	In this work, we studied the effect of iron in the activation of MAPK/ERK pathway and on Ca2+ signaling in neuronal PC12 cells.	Iron	39-43	Eph receptor B1	Rattus norvegicus	70-73
16629179-4	2006	We found that iron-dependent generation of hydroxyl radicals is likely to modulate Ca2+ signaling through RyR calcium channel activation, which, in turn, activates the MAPK/ERK pathway.	Iron	14-18	Eph receptor B1	Rattus norvegicus	173-176
16629180-6	2006	The results indicate that Hepc released by HepG2 inhibited apical iron uptake by Caco-2 cells, probably by inhibiting the expression of the apical transporter DMT1.	Iron	66-70	charged multivesicular body protein 2B	Homo sapiens	159-163
16141353-1	2006	Congenital dyserythropoietic anemia type I (CDA I) is a rare autosomal recessive disorder with ineffective erythropoiesis and iron overloading.	Iron	126-130	codanin 1	Homo sapiens	0-42
16141353-1	2006	Congenital dyserythropoietic anemia type I (CDA I) is a rare autosomal recessive disorder with ineffective erythropoiesis and iron overloading.	Iron	126-130	codanin 1	Homo sapiens	44-49
16540419-3	2006	In humans, iron-deficiency results in anemia, while excess iron can lead to organ damage as a result of a build-up of non-transferrin-bound iron (NTBI).	Iron	59-63	transferrin	Homo sapiens	122-133
17017915-5	2006	The molecular targets of in vivo active compounds were identified using reagents designed and synthesized based on the SAR, including the identification of tail-interacting protein 47 (TIP47), an insulin-like growth factor II (IGF II) receptor binding protein, as the molecular target of 3-aryl-5-aryl-1,2,4-oxadiazoles; and Transferrin receptor I (TfR), a transmembrane protein that interacts with transferrin (Tf) for the transport of iron into cells, as the molecular target of gambogic acid.	Iron	437-441	perilipin 3	Homo sapiens	156-183
17017915-5	2006	The molecular targets of in vivo active compounds were identified using reagents designed and synthesized based on the SAR, including the identification of tail-interacting protein 47 (TIP47), an insulin-like growth factor II (IGF II) receptor binding protein, as the molecular target of 3-aryl-5-aryl-1,2,4-oxadiazoles; and Transferrin receptor I (TfR), a transmembrane protein that interacts with transferrin (Tf) for the transport of iron into cells, as the molecular target of gambogic acid.	Iron	437-441	perilipin 3	Homo sapiens	185-190
16275145-0	2006	Purified human chondroitin-4-sulfate reduced MMP/TIMP imbalance induced by iron plus ascorbate in human fibroblast cultures.	Iron	75-79	TIMP metallopeptidase inhibitor 1	Homo sapiens	49-53
16681422-6	2006	CONCLUSIONS: The antioxidant role of haptoglobin and the phenotype dependence were confirmed for preventing possible oxidative damage induced by free hemoglobin and iron release during its catabolism.	Iron	165-169	haptoglobin	Homo sapiens	37-48
16669553-3	2006	RESULTS: The prevalence of increased serum iron stores in patients with HCV infection is 28% (patients having an elevated ferritin or transferrin saturation).	Iron	43-47	transferrin	Homo sapiens	134-145
16842166-5	2006	Subsequent studies have revealed that HIF-1 is also activated by environmental and physiological stimuli that range from iron chelators to hormones.	Iron	68-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-43
16921248-2	2006	Subsequently the basis has been shown to be a neurodegeneration with brain iron accumulation or pantothenate kinase-associated neurodegeneration due to mutations in the pantothenate kinase 2 (PANK2) gene.	Iron	75-79	pantothenate kinase 2	Homo sapiens	192-197
16798643-0	2006	Iron mobilization from transferrin and non-transferrin-bound-iron by deferiprone.	Iron	0-4	transferrin	Homo sapiens	23-34
16540422-0	2006	Erythropoietin administration may potentiate mobilization of storage iron in patients on oral iron chelation therapy.	Iron	69-73	erythropoietin	Homo sapiens	0-14
16798643-0	2006	Iron mobilization from transferrin and non-transferrin-bound-iron by deferiprone.	Iron	61-65	transferrin	Homo sapiens	43-54
16540422-0	2006	Erythropoietin administration may potentiate mobilization of storage iron in patients on oral iron chelation therapy.	Iron	94-98	erythropoietin	Homo sapiens	0-14
16798643-2	2006	Iron mobilization from transferrin is one of the most important screening methods for the selection of chelators intended for clinical use in the treatment of iron overload in thalassemia and other conditions.	Iron	0-4	transferrin	Homo sapiens	23-34
16798643-2	2006	Iron mobilization from transferrin is one of the most important screening methods for the selection of chelators intended for clinical use in the treatment of iron overload in thalassemia and other conditions.	Iron	159-163	transferrin	Homo sapiens	23-34
16798643-4	2006	Iron mobilization from transferrin and non-transferrin-bound-iron (NTBI) can be used to optimize existing chelation therapy protocols for the treatment of iron loaded patients.	Iron	0-4	transferrin	Homo sapiens	23-34
16798643-4	2006	Iron mobilization from transferrin and non-transferrin-bound-iron (NTBI) can be used to optimize existing chelation therapy protocols for the treatment of iron loaded patients.	Iron	61-65	transferrin	Homo sapiens	43-54
16798643-4	2006	Iron mobilization from transferrin and non-transferrin-bound-iron (NTBI) can be used to optimize existing chelation therapy protocols for the treatment of iron loaded patients.	Iron	155-159	transferrin	Homo sapiens	23-34
16798646-9	2006	Three patients had increased iron scores after therapy of L1 and 11 patients had increased ALT levels; increased ALT levels occurred more frequently in hepatitis C positive patients.	Iron	29-33	immunoglobulin kappa variable 1-16	Homo sapiens	58-67
16540426-5	2006	A 10-year follow-up shows a marked decrease in the concentration of serum ferritin, non-transferrin-bound iron (NTBI), liver iron and normal hemoglobin (Hb), which allows the patient to reach and maintain a good quality of life.	Iron	106-110	transferrin	Homo sapiens	88-99
16798647-10	2006	Chelation therapy using L1 or appropriate L1/DFO combinations can reduce cardiac iron overload and the mortality rate in thalassemia patients.	Iron	81-85	immunoglobulin kappa variable 1-16	Homo sapiens	42-48
16403408-2	2006	The pathophysiologic effects of iron overload relate to increased non-transferrin bound iron generating toxic oxygen free radicals.	Iron	32-36	transferrin	Homo sapiens	70-81
16603447-8	2006	Transferrin was coupled to liposomes by a technique which involves the prevention of scavenging diferric iron atoms of transferrin.	Iron	105-109	transferrin	Homo sapiens	0-11
16603447-8	2006	Transferrin was coupled to liposomes by a technique which involves the prevention of scavenging diferric iron atoms of transferrin.	Iron	105-109	transferrin	Homo sapiens	119-130
16877869-8	2006	RESULTS: The heritability (h(2) +/- SE) estimates were 0.23 +/- 0.07 (p &lt; 0.0001) for iron, 0.29 +/- 0.09 (p &lt; 0.0001) for ferritin and 0.28 +/- 0.07 (p &lt; 0.0001) for transferrin saturation while adjusting for age, age(2) and sex.	Iron	89-93	transferrin	Homo sapiens	176-187
16679553-3	2006	Iron-induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase- 3 activation, NF-kappaB induction, and decreased Bcl-2 expression, without any significant change in Bax expression.	Iron	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	182-191
16679553-3	2006	Iron-induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase- 3 activation, NF-kappaB induction, and decreased Bcl-2 expression, without any significant change in Bax expression.	Iron	0-4	B cell leukemia/lymphoma 2	Mus musculus	217-222
16403408-2	2006	The pathophysiologic effects of iron overload relate to increased non-transferrin bound iron generating toxic oxygen free radicals.	Iron	88-92	transferrin	Homo sapiens	70-81
16860490-13	2006	The combination of iron administration (by injection or oral rout), hemin, or transferrin, as a source for iron, HBO(2) as a source of oxygen under pressure and PDT as a source of generating free-radical tissue damage may be useful in the treatment of tumors.	Iron	107-111	transferrin	Homo sapiens	78-89
16226391-7	2006	The pathogenesis of ACD had been poorly understood, but recently it has been shown that increased Il-6 upregulates the hepatic production of hepcidin, which, by binding to its cellular receptor, ferroportin, causes anemia by blocking iron export from enterocytes and macrophages.	Iron	234-238	interleukin 6	Homo sapiens	98-102
16326028-10	2006	Our hypothesis may also partially explain why gallium, an atomically iron-like toxic metal that binds to transferrin and the TfR is incorporated into cells and was previously demonstrated to have anti-tumor activity in patients with lymphomas refractory to other chemotherapeutic treatments.	Iron	69-73	transferrin	Homo sapiens	105-116
16091957-1	2006	The H(+) -coupled divalent metal-ion transporter DMT1 serves as both the primary entry point for iron into the body (intestinal brush-border uptake) and the route by which transferrin-associated iron is mobilized from endosomes to cytosol in erythroid precursors and other cells.	Iron	97-101	transferrin	Homo sapiens	172-183
16645227-4	2006	Biochemical markers, especially the soluble transferrin receptor/log ferritin ratio (ferritin index), are useful indicators of the iron supply to erythropoiesis.	Iron	131-135	transferrin	Homo sapiens	44-55
16645227-8	2006	In patients receiving epoetin therapy, the plot is an important tool for monitoring erythropoietic activity, functional iron deficiency, and adequate iron stores for new red cell production.	Iron	120-124	erythropoietin	Homo sapiens	22-29
16645227-12	2006	The diagnostic plot is a model for differentiating iron-deficient states and predicting those patients who will respond to epoetin therapy.	Iron	51-55	erythropoietin	Homo sapiens	123-130
16317519-5	2006	Western blot was performed to detect the expression of iron transport proteins: divalent metal transporter1 (DMT1) and ferroportin 1 (FPN1) in duodenal epithelium.	Iron	55-59	solute carrier family 40 member 1	Rattus norvegicus	119-132
16317519-5	2006	Western blot was performed to detect the expression of iron transport proteins: divalent metal transporter1 (DMT1) and ferroportin 1 (FPN1) in duodenal epithelium.	Iron	55-59	solute carrier family 40 member 1	Rattus norvegicus	134-138
16317519-8	2006	The data suggested that moderate exercise improved iron status and that was likely regulated by increased DMT1 with IRE and FPN1 expression.	Iron	51-55	solute carrier family 40 member 1	Rattus norvegicus	124-128
16317519-9	2006	Hepcidin signaling pathway may involve in the regulation of duodenal iron absorption proteins.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
16144853-1	2006	BACKGROUND: Intravenous iron is a recognized therapy of anaemia in chronic haemodialyzed patients, especially in those receiving erythropoietin (Epo), while its role in the anaemia of pre-dialyzed chronic renal failure (CRF) patients is much less clear.	Iron	24-28	erythropoietin	Homo sapiens	129-143
16144853-1	2006	BACKGROUND: Intravenous iron is a recognized therapy of anaemia in chronic haemodialyzed patients, especially in those receiving erythropoietin (Epo), while its role in the anaemia of pre-dialyzed chronic renal failure (CRF) patients is much less clear.	Iron	24-28	erythropoietin	Homo sapiens	145-148
16144853-8	2006	CONCLUSIONS: Intravenous iron therapy in pre-dialysis patients with no Epo seems often to ameliorate the anaemia, avoiding the necessity of Epo or blood transfusions in one-third of pre-dialyzed non-diabetic patients.	Iron	25-29	erythropoietin	Homo sapiens	71-74
16144853-8	2006	CONCLUSIONS: Intravenous iron therapy in pre-dialysis patients with no Epo seems often to ameliorate the anaemia, avoiding the necessity of Epo or blood transfusions in one-third of pre-dialyzed non-diabetic patients.	Iron	25-29	erythropoietin	Homo sapiens	140-143
16464747-6	2006	Consequently performed mutation analyses in genes involved in brain iron metabolism lead to the discovery of specific mutations in the ferritin-H, IRP2 and HFE gene in single PD patients.	Iron	68-72	iron responsive element binding protein 2	Homo sapiens	147-151
17176219-7	2006	Iron overload as determined by transferrin saturation and elevated serum ferritin was observed in 4.3% of patients with esophageal cancer and 0.7% of control subjects and was not associated with the consumption of home-brewed beer.	Iron	0-4	transferrin	Homo sapiens	31-42
16091957-1	2006	The H(+) -coupled divalent metal-ion transporter DMT1 serves as both the primary entry point for iron into the body (intestinal brush-border uptake) and the route by which transferrin-associated iron is mobilized from endosomes to cytosol in erythroid precursors and other cells.	Iron	195-199	transferrin	Homo sapiens	172-183
16819431-1	2006	The iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	4-8	iron responsive element binding protein 2	Homo sapiens	39-43
16819431-1	2006	The iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	99-103	iron responsive element binding protein 2	Homo sapiens	39-43
16197918-0	2005	Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: active site contributions to drug inhibition.	Iron	70-74	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	82-119
16363792-9	2005	When this investigation is taken together with other functional studies of CBS, it provides strong evidence that coordination of Cys52 to the heme iron is crucial for full activity in this enzyme.	Iron	147-151	cystathionine beta-synthase	Homo sapiens	75-78
16377569-4	2005	Intracellular iron delivery blocks Bim induction and suppresses apoptosis due to 24p3 addition or IL-3 deprivation.	Iron	14-18	interleukin 3	Mus musculus	98-102
16223732-4	2005	Here we show that the glucose metabolites pyruvate and oxaloacetate inactivate HIF-1alpha decay in a manner selectively reversible by ascorbate, cysteine, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen.	Iron	170-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
16137650-1	2005	Heme oxygenase cleaves heme to form biliverdin, carbon monoxide (CO), and iron, and consists of two structurally related isozymes, HO-1 and HO-2.	Iron	74-78	heme oxygenase 1	Mus musculus	131-144
16686997-6	2006	This may due to the enzymatic ability of over-expressed CuZn-superoxide dismutase in Down syndrome to catalyze the formation of H2O2 from O2*-, thereby increasing the availability of substrate H2O2 for the iron-dependent generation of HO* via the Fenton reaction, suggesting that HO* generated from DS-GF may be involved in progressive periodontitis of Down syndrome.	Iron	206-210	superoxide dismutase 1	Homo sapiens	56-81
16600091-14	2006	CONCLUSION: The long term exposure to the manganese can induce the disorder of the iron metabolism, which is found in the expression of increase of the serum iron and transferrin as well as the decrease of transferrin receptors.	Iron	83-87	transferrin	Homo sapiens	167-178
16600091-14	2006	CONCLUSION: The long term exposure to the manganese can induce the disorder of the iron metabolism, which is found in the expression of increase of the serum iron and transferrin as well as the decrease of transferrin receptors.	Iron	83-87	transferrin	Homo sapiens	206-217
16475353-9	2005	The reaction products produced by the media in domestic tap water had average As-to-Fe ratios that were approximately 25% higher than those for a commercially available adsorbent.	Iron	84-86	SEC14 like lipid binding 2	Homo sapiens	56-59
16115609-1	2005	The microsomal heme oxygenase system consists of heme oxygenase (HO) and NADPH-cytochrome P450 reductase, and plays a key role in the physiological catabolism of heme which yields biliverdin, carbon monoxide, and iron as the final products.	Iron	213-217	cytochrome p450 oxidoreductase	Homo sapiens	73-104
16115734-1	2005	HO-2 is a constitutive isoform of heme oxygenase (HO), a microsomal enzyme that catalyzes the cleavage of the heme ring to form ferrous iron, carbon monoxide, and biliverdin.	Iron	128-140	heme oxygenase 2	Rattus norvegicus	0-4
15943579-1	2005	The present paper describes an anion-exchange chromatography method to separate iron-free apo-Tf (apo-transferrin) from albumin and IgG in Cohn supernatant I.	Iron	80-84	transferrin	Homo sapiens	102-113
16286504-4	2005	Ablating SLC11A2, the gene for the divalent metal ion transporter DMT1, supports evidence from the Belgrade rat and mk mouse models establishing DMT1 as the primary mechanism serving apical uptake of nonheme iron.	Iron	208-212	solute carrier family 11 member 2	Rattus norvegicus	9-16
16286504-4	2005	Ablating SLC11A2, the gene for the divalent metal ion transporter DMT1, supports evidence from the Belgrade rat and mk mouse models establishing DMT1 as the primary mechanism serving apical uptake of nonheme iron.	Iron	208-212	solute carrier family 11 member 2	Rattus norvegicus	66-70
16092918-1	2005	TfR1 (transferrin receptor 1) mediates the uptake of transferrin-bound iron and thereby plays a critical role in cellular iron metabolism.	Iron	71-75	transferrin	Homo sapiens	6-17
16092918-1	2005	TfR1 (transferrin receptor 1) mediates the uptake of transferrin-bound iron and thereby plays a critical role in cellular iron metabolism.	Iron	122-126	transferrin	Homo sapiens	6-17
16226717-7	2005	This contrasts sharply with the P450-catalyzed reaction, which is brought about by iron-bound peroxide that is inaccessible to catalase.	Iron	83-87	catalase	Homo sapiens	127-135
16224057-0	2005	Tumor necrosis factor-alpha-induced iron sequestration and oxidative stress in human endothelial cells.	Iron	36-40	tumor necrosis factor	Homo sapiens	0-27
16224057-3	2005	We tested whether TNF-alpha accelerated iron accumulation in vascular endothelium, favoring synthesis of hydroxyl radical.	Iron	40-44	tumor necrosis factor	Homo sapiens	18-27
16224057-6	2005	These changes in iron transporters were accompanied by accumulation of iron that was both transferrin-dependent and transferrin-independent.	Iron	17-21	transferrin	Homo sapiens	90-101
16224057-6	2005	These changes in iron transporters were accompanied by accumulation of iron that was both transferrin-dependent and transferrin-independent.	Iron	17-21	transferrin	Homo sapiens	116-127
16224057-9	2005	CONCLUSIONS: TNF-alpha could cause intracellular iron sequestration, which may participate importantly in the pathophysiology of atherosclerosis and cardiovascular disease.	Iron	49-53	tumor necrosis factor	Homo sapiens	13-22
16281958-4	2005	Nonetheless, intravenous iron therapy has effects on endothelial cells, polymorphonuclear leucocytes and cytokines which are most likely related to non-transferrin bound labile iron.	Iron	25-29	transferrin	Homo sapiens	152-163
16351643-11	2005	Anti-IL-6 antiserum normalised iron absorption in mice exposed to hypoxia, because of a reduction in the MT.	Iron	31-35	interleukin 6	Mus musculus	5-9
16351643-12	2005	These data indicate that IL-6 can influence iron absorption (especially MT) during the hypoxic exposure, but via a mechanism independent of hepcidin.	Iron	44-48	interleukin 6	Mus musculus	25-29
16286684-9	2005	Transferrin saturation in the -Fe and -Zn-Fe groups was significantly lower than the Cont group (p &lt; 0.01), and that of the -Zn group was highest among all groups.	Iron	31-33	transferrin	Rattus norvegicus	0-11
16351643-0	2005	Role of interleukin-6 in hypoxic regulation of intestinal iron absorption.	Iron	58-62	interleukin 6	Mus musculus	8-21
16351643-6	2005	A significant positive correlation existed between the total iron uptake and IL-6 levels in circulation.	Iron	61-65	interleukin 6	Mus musculus	77-81
16330325-7	2005	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis.	Iron	104-108	transforming growth factor beta 1	Homo sapiens	35-43
16330325-7	2005	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis.	Iron	123-127	transforming growth factor beta 1	Homo sapiens	35-43
16336085-6	2005	Efforts have been made to identify treatable causes of erythropoietin refractoriness, such as functional iron deficiency, and concomitant intravenous iron supplementation does appear to improve response rates.	Iron	105-109	erythropoietin	Homo sapiens	55-69
16338492-5	2005	MATERIALS AND METHODS: RBC derived from mice transplanted with Sod2-deficient hematopoietic stem cells served as a source of iron-laden cells.	Iron	125-129	superoxide dismutase 2, mitochondrial	Mus musculus	63-67
16338492-6	2005	Purification was based upon the observation that iron deposits in Sod2-deficient cells are "magnetically susceptible" and allow for retention of iron-laden cells in a strong magnetic field.	Iron	49-53	superoxide dismutase 2, mitochondrial	Mus musculus	66-70
16338492-6	2005	Purification was based upon the observation that iron deposits in Sod2-deficient cells are "magnetically susceptible" and allow for retention of iron-laden cells in a strong magnetic field.	Iron	145-149	superoxide dismutase 2, mitochondrial	Mus musculus	66-70
16139917-4	2005	Biometric, clinical and biochemical variables including those susceptible to influence body iron stores were tested for association with transferrin saturation levels &lt;45%.	Iron	92-96	transferrin	Homo sapiens	137-148
16289749-0	2005	Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking.	Iron	0-4	exocyst complex component 6	Mus musculus	51-58
16389572-1	2005	OBJECTIVES: Heme oxygenase-1 (HO-1) is an enzyme that degrades heme into biliverdin, free iron, and carbon monoxide (CO).	Iron	90-94	heme oxygenase 1	Mus musculus	12-28
16389572-1	2005	OBJECTIVES: Heme oxygenase-1 (HO-1) is an enzyme that degrades heme into biliverdin, free iron, and carbon monoxide (CO).	Iron	90-94	heme oxygenase 1	Mus musculus	30-34
19829748-6	2005	This function of NF-kappaB involves an induction of mitochondrial anti-oxidant enzyme, manganese superoxide dismutase (Mn-SOD), and a control of cellular iron availability through upregulation of Ferritin heavy chain - one of two subunits of Ferritin, the major iron storage protein complex of the cell.	Iron	154-158	nuclear factor kappa B subunit 1	Homo sapiens	17-26
19829748-6	2005	This function of NF-kappaB involves an induction of mitochondrial anti-oxidant enzyme, manganese superoxide dismutase (Mn-SOD), and a control of cellular iron availability through upregulation of Ferritin heavy chain - one of two subunits of Ferritin, the major iron storage protein complex of the cell.	Iron	262-266	nuclear factor kappa B subunit 1	Homo sapiens	17-26
16343946-3	2005	Thus, in vertebrates iron is transported through the circulation bound to transferrin (Tf) and delivered to cells through an endocytotic cycle involving the transferrin receptor (TfR).	Iron	21-25	transferrin	Homo sapiens	74-85
16209887-2	2005	Although it is still unclear as to which species are active in biological media, they all readily deliver Ti(IV) to transferrin, the protein that transports iron in the blood.	Iron	157-161	transferrin	Homo sapiens	116-127
16343946-3	2005	Thus, in vertebrates iron is transported through the circulation bound to transferrin (Tf) and delivered to cells through an endocytotic cycle involving the transferrin receptor (TfR).	Iron	21-25	transferrin	Homo sapiens	87-89
16343946-4	2005	We have previously presented a model for the Tf-TfR complex in its iron-bearing form, the diferric transferrin (dTf)-TfR complex [Cheng, Y., Zak, O., Aisen, P., Harrison, S.C., Walz, T., 2004.	Iron	67-71	transferrin	Homo sapiens	99-110
16343946-4	2005	We have previously presented a model for the Tf-TfR complex in its iron-bearing form, the diferric transferrin (dTf)-TfR complex [Cheng, Y., Zak, O., Aisen, P., Harrison, S.C., Walz, T., 2004.	Iron	67-71	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	141-144
16343946-7	2005	We have now calculated a single particle reconstruction for the complex in its iron-free form, the apo-transferrin (apoTf)-TfR complex.	Iron	79-83	transferrin	Homo sapiens	103-114
16095759-0	2005	Iron loading inhibits ferroportin1 expression in PC12 cells.	Iron	0-4	solute carrier family 40 member 1	Rattus norvegicus	22-34
16316349-1	2005	BACKGROUND: The heme oxygenase system (HO-1 and HO-2) catalyzes the conversion of heme to free iron, carbon monoxide (CO), a vasodepressor, and biliverdin, which is further converted to bilirubin, an antioxidant.	Iron	95-99	heme oxygenase 2	Rattus norvegicus	48-52
16316358-4	2005	RESULTS: Iron infusion increased total (Delta 601 microg/100 mL, CI 507, 696) and non-transferrin-bound iron (Delta 237.2 micromol/L, CI 173.6, 300.8) approximately 10-fold, as well as redox-active iron nearly five-fold (Delta 0.76 micromol/L, CI 0.54, 0.98).	Iron	9-13	transferrin	Homo sapiens	86-97
16316358-10	2005	CONCLUSION: Our data suggest that 300 mg intravenous iron sucrose has a vasodilatory effect, but does not impair vascular reactivity in dialysis patients, despite a significant increase in non-transferrin-bound and redox-active iron.	Iron	53-57	transferrin	Homo sapiens	193-204
16316362-5	2005	Compared to those in the IV iron group, patients in the oral iron treatment group showed a greater decline in GFR during the study (-4.40 vs. -1.45 mL/min/1.73m2, P= 0.0100).	Iron	61-65	CD59 molecule (CD59 blood group)	Homo sapiens	151-156
16095759-1	2005	Ferroportin1 (FP1 or MTP1/IREG1), the product of the SLC40A1 gene, is a main iron export protein in mammals.	Iron	77-81	solute carrier family 40 member 1	Rattus norvegicus	0-12
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	148-152	transferrin	Rattus norvegicus	40-51
16095759-1	2005	Ferroportin1 (FP1 or MTP1/IREG1), the product of the SLC40A1 gene, is a main iron export protein in mammals.	Iron	77-81	solute carrier family 40 member 1	Rattus norvegicus	53-60
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	157-159	transferrin	Rattus norvegicus	40-51
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	114-118	transferrin	Rattus norvegicus	40-51
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	114-118	transferrin	Rattus norvegicus	96-107
16285738-6	2005	Treatment of IDE with AAHP or hydrogen peroxide increased its susceptibility to proteolysis, while treatment of NEP with iron/ascorbate or hydrogen peroxide increased its susceptibility to proteolysis.	Iron	121-125	membrane metalloendopeptidase	Homo sapiens	112-115
16251171-7	2005	There was a positive correlation between Hb and plasma iron and transferrin saturation in group 1 and disease beginning age, iron, transferrin saturation, and erythrocyte sedimentation rate (ESR) in the second group.	Iron	55-59	transferrin	Homo sapiens	64-75
16297069-0	2005	A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading.	Iron	58-62	YELLOW STRIPE like 1	Arabidopsis thaliana	31-37
16297069-6	2005	More importantly, seeds of both ysl1 knockouts contained less iron and nicotianamine than wild-type seeds, even when produced by plants grown in the presence of an excess of iron.	Iron	62-66	YELLOW STRIPE like 1	Arabidopsis thaliana	32-36
16297069-6	2005	More importantly, seeds of both ysl1 knockouts contained less iron and nicotianamine than wild-type seeds, even when produced by plants grown in the presence of an excess of iron.	Iron	174-178	YELLOW STRIPE like 1	Arabidopsis thaliana	32-36
16297069-8	2005	ysl1 seeds germinated slowly, but this defect was rescued by an iron supply.	Iron	64-68	YELLOW STRIPE like 1	Arabidopsis thaliana	0-4
16297069-9	2005	AtYSL1 was expressed in the xylem parenchyma of leaves, where it was upregulated in response to iron excess, as well as in pollen and in young silique parts.	Iron	96-100	YELLOW STRIPE like 1	Arabidopsis thaliana	0-6
16297069-11	2005	Taken together, our work provides strong physiological evidence that iron and nicotianamine levels in seeds rely in part on AtYSL1 function.	Iron	69-73	YELLOW STRIPE like 1	Arabidopsis thaliana	124-130
16290184-0	2005	Removal of As(III) and As(V) from water using a natural Fe and Mn enriched sample.	Iron	56-58	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
16214107-5	2005	Both iron(III) MPO and iron(II) MPO are rapidly converted to compound II by peroxynitrite in monophasic reactions with calculated rate constants of (6.8+/-0.1) x 10(6) M(-1)s(-1) and (1.3+/-0.2) x 10(6) M(-1)s(-1), respectively (pH 7.0 and 25 degrees C).	Iron	5-9	myeloperoxidase	Homo sapiens	15-18
16214107-5	2005	Both iron(III) MPO and iron(II) MPO are rapidly converted to compound II by peroxynitrite in monophasic reactions with calculated rate constants of (6.8+/-0.1) x 10(6) M(-1)s(-1) and (1.3+/-0.2) x 10(6) M(-1)s(-1), respectively (pH 7.0 and 25 degrees C).	Iron	23-27	myeloperoxidase	Homo sapiens	32-35
16285738-1	2005	Insulysin (IDE) and neprilysin (NEP) were found to be inactivated by oxidation with hydrogen peroxide, an iron-ascorbate oxidation system, and by treatment with 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH).	Iron	106-110	membrane metalloendopeptidase	Homo sapiens	20-30
16285738-1	2005	Insulysin (IDE) and neprilysin (NEP) were found to be inactivated by oxidation with hydrogen peroxide, an iron-ascorbate oxidation system, and by treatment with 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH).	Iron	106-110	membrane metalloendopeptidase	Homo sapiens	32-35
15968631-8	2005	The toxic concentration of IFN-gamma, and TNF-alpha was lower if the cells were iron loaded, but iron loading had no effect on the toxicity of IL-1beta.	Iron	80-84	interferon gamma	Homo sapiens	27-36
15968631-8	2005	The toxic concentration of IFN-gamma, and TNF-alpha was lower if the cells were iron loaded, but iron loading had no effect on the toxicity of IL-1beta.	Iron	80-84	tumor necrosis factor	Homo sapiens	42-51
16344607-5	2005	We speculated that a parenchymal iron deposition in mild ALD is an important factor to trigger hepatocytes injury by ethanol, and the possible cause of parencynal iron deposition may be an increase of cellular iron uptake via serum transferrin in hepatocytes after ethanol exposure.	Iron	163-167	transferrin	Homo sapiens	232-243
16280434-3	2005	OBJECTIVE: The objective was to ascertain whether supplemental iron intakes are associated with increases in iron transport (transferrin saturation) and stores (serum ferritin) among US adults aged &gt; or = 19 y.	Iron	63-67	transferrin	Homo sapiens	125-136
16225476-1	2005	BACKGROUND: Preliminary clinical and experimental results suggest that iron can modify hepatocytes" insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling.	Iron	71-75	insulin	Homo sapiens	100-107
16225476-1	2005	BACKGROUND: Preliminary clinical and experimental results suggest that iron can modify hepatocytes" insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling.	Iron	71-75	insulin	Homo sapiens	140-147
16225476-1	2005	BACKGROUND: Preliminary clinical and experimental results suggest that iron can modify hepatocytes" insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling.	Iron	71-75	insulin	Homo sapiens	140-147
16225476-4	2005	Iron depletion by desferrioxamine increased by twofold the 125I-insulin-specific binding, whereas iron addition reduced insulin binding, similarly to cells exposed to high glucose concentration.	Iron	0-4	insulin	Homo sapiens	64-71
16225476-4	2005	Iron depletion by desferrioxamine increased by twofold the 125I-insulin-specific binding, whereas iron addition reduced insulin binding, similarly to cells exposed to high glucose concentration.	Iron	98-102	insulin	Homo sapiens	120-127
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	12-16	insulin	Homo sapiens	32-39
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	12-16	insulin	Homo sapiens	120-127
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	12-16	insulin	Homo sapiens	120-127
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	12-16	insulin	Homo sapiens	120-127
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	331-335	insulin	Homo sapiens	32-39
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	331-335	insulin	Homo sapiens	120-127
16344607-5	2005	We speculated that a parenchymal iron deposition in mild ALD is an important factor to trigger hepatocytes injury by ethanol, and the possible cause of parencynal iron deposition may be an increase of cellular iron uptake via serum transferrin in hepatocytes after ethanol exposure.	Iron	163-167	transferrin	Homo sapiens	232-243
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	331-335	insulin	Homo sapiens	120-127
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	331-335	insulin	Homo sapiens	120-127
16344607-6	2005	By immuno-histochemical study of biopsied liver samples, the expression of transferrin receptor 1 (TfR1), which mediates cellular iron uptake by serum transferrin was increased.	Iron	130-134	transferrin	Homo sapiens	75-86
16344607-8	2005	Fe-labeled transferrin incorporation (but not transferrin non-bound iron (NTBI)) into the cells is also increased, suggesting that the increased TfR1 is functional.	Iron	0-2	transferrin	Homo sapiens	11-22
16356114-11	2005	In conclusion, glucose promotes iron-mediated oxidation of apoB- 100 proline and arginine residues via a superoxide-dependent mechanism, thus rendering the LDL particles more atherogenic.	Iron	32-36	apolipoprotein B	Homo sapiens	59-68
16261255-1	2005	Lactoferrin is an iron-binding glycoprotein of the transferrin family.	Iron	18-22	transferrin	Homo sapiens	51-62
16287257-3	2005	The ligated substrates included complex sugars, peptides, poly(ethylene oxide) polymers, and the iron carrier protein transferrin, with routine success even for cases that were previously resistant to azide-alkyne coupling using the conventional ligand tris(triazolyl)amine (1).	Iron	97-101	transferrin	Homo sapiens	118-129
16100038-0	2005	Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats.	Iron	0-4	angiotensinogen	Rattus norvegicus	100-114
16100038-1	2005	OBJECTIVE: We have investigated whether long-term administration of angiotensin (Ang) II causes ferritin induction and iron accumulation in the rat aorta, and their possible relation to regulatory effects on gene expression and vascular function in Ang II-infused animals.	Iron	119-123	angiotensinogen	Rattus norvegicus	68-88
16100038-5	2005	Prussian blue staining showed that stainable iron was observed in the adventitial layer of aorta from Ang II-infused animals, but not in the endothelial layer.	Iron	45-49	angiotensinogen	Rattus norvegicus	102-108
16100038-7	2005	In addition, iron chelation attenuated Ang II-induced impairment of aortic relaxations in response to acetylcholine and sodium nitroprusside and suppressed upregulation of mRNA levels of monocyte chemoattractant protein-1.	Iron	13-17	angiotensinogen	Rattus norvegicus	39-45
16100038-8	2005	Iron chelation also partially attenuated the medial thickening and perivascular fibrosis induced by Ang II infusion for 4 weeks.	Iron	0-4	angiotensinogen	Rattus norvegicus	100-106
16100038-9	2005	CONCLUSIONS: Ang II infusion caused ferritin induction and iron deposition in the aortas.	Iron	59-63	angiotensinogen	Rattus norvegicus	13-19
16014567-9	2005	Collectively, our results suggest that iron chelators may function as antitumor and radioenhancing agents and uncover a previously unexplored activity of iron chelators in activation of ATR and checkpoint kinases.	Iron	39-43	ATR serine/threonine kinase	Homo sapiens	186-189
16014567-9	2005	Collectively, our results suggest that iron chelators may function as antitumor and radioenhancing agents and uncover a previously unexplored activity of iron chelators in activation of ATR and checkpoint kinases.	Iron	154-158	ATR serine/threonine kinase	Homo sapiens	186-189
16308480-5	2005	While total RNA yield and abundance were not significantly altered, both iron and aluminum were found to induce HSP27, COX-2, betaAPP and DAXX gene expression.	Iron	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
16203876-6	2005	Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues.	Iron	52-56	angiotensinogen	Rattus norvegicus	13-27
16203876-6	2005	Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues.	Iron	52-56	angiotensinogen	Rattus norvegicus	96-110
16203876-7	2005	Abnormal lipid metabolism may be associated with upregulation of TGF-beta1 expression and aberrant iron homeostasis in the kidneys of angiotensin II-infused animals.	Iron	99-103	angiotensinogen	Rattus norvegicus	134-148
16308487-3	2005	Elevation of iron in Alzheimer"s disease not only affects amyloid precursor protein processing and mitochondrial function but also induces the aggregation of Abeta peptide and abnormalities in signal transduction processes associated with oxidative damage.	Iron	13-17	amyloid beta precursor protein	Homo sapiens	58-83
16308487-3	2005	Elevation of iron in Alzheimer"s disease not only affects amyloid precursor protein processing and mitochondrial function but also induces the aggregation of Abeta peptide and abnormalities in signal transduction processes associated with oxidative damage.	Iron	13-17	amyloid beta precursor protein	Homo sapiens	158-163
16126304-8	2005	Based on the equilibrium reductions of NO3- and SO4(2-) by Fe0 and mineral precipitation, geochemical modeling predicted a maximum of 49% porosity loss for 5 yr of operation.	Iron	59-62	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
16315136-3	2005	Most of the iron that enters the liver is derived from plasma transferrin under normal circumstances, and transferrin receptors 1 and 2 play important roles in this process.	Iron	12-16	transferrin	Homo sapiens	62-73
16271884-0	2005	The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.	Iron	48-52	transferrin	Homo sapiens	100-111
16315136-4	2005	In pathological situations, non-transferrin-bound iron, ferritin, and hemoglobin/haptoglobin and heme/hemopexin complexes assume greater importance in iron delivery to the organ.	Iron	50-54	transferrin	Homo sapiens	32-43
16315136-4	2005	In pathological situations, non-transferrin-bound iron, ferritin, and hemoglobin/haptoglobin and heme/hemopexin complexes assume greater importance in iron delivery to the organ.	Iron	151-155	transferrin	Homo sapiens	32-43
16271884-1	2005	Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process.	Iron	41-45	transferrin	Homo sapiens	6-17
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Iron	192-196	cytoglobin	Homo sapiens	0-10
16271884-1	2005	Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process.	Iron	117-121	transferrin	Homo sapiens	6-17
16212360-10	2005	The orbital interactions between iron(III) and porphyrin have been examined on the basis of these chemical shifts, from which we have found that both the d(xy)-a(2u) interaction in the ruffled Fe(T(i)PrP)L2+ and d(xy)-a(1u) interaction in the saddled Fe(OETPP)L2+ are quite weak in the high-spin and probably in the intermediate-spin complexes as well.	Iron	33-37	prion protein	Homo sapiens	200-203
16283525-4	2005	Nickel may interfere with iron at both an extracellular level, by preventing iron from being transported into the cell, and at an intracellular level, by competing for iron sites on enzymes like the prolyl hydroxylases that modify hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	26-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-262
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Iron	192-196	cytoglobin	Homo sapiens	12-15
16142416-9	2005	Serum iron concentration was lowered both in IFN-gamma receptor-deficient and wild-type mice.	Iron	6-10	interferon gamma	Mus musculus	45-54
16105652-5	2005	Immunoblot and immunofluorescence analyses revealed that treatment with hypoxia or an iron chelator, desferrioxamine, induced nuclear accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) in HPTECs.	Iron	86-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-181
16105652-5	2005	Immunoblot and immunofluorescence analyses revealed that treatment with hypoxia or an iron chelator, desferrioxamine, induced nuclear accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) in HPTECs.	Iron	86-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	183-193
16041604-6	2005	On-line specific detection of the iron associated with the different Tf isoforms, after Fe saturation, by inductively coupled plasma mass spectrometry (ICP-MS) was studied in detail to compare its analytical performance with UV detection.	Iron	34-38	transferrin	Homo sapiens	69-71
16041604-10	2005	Interesting results from iron speciation of Tf in serum from healthy individuals and from pregnant women are given.	Iron	25-29	transferrin	Homo sapiens	44-46
15979061-0	2005	Serum non-transferrin bound iron in hemodialysis patients not receiving intravenous iron.	Iron	28-32	transferrin	Homo sapiens	10-21
15979061-1	2005	BACKGROUND: Non-transferrin bound iron (NTBI) has been found to be raised in end stage renal disease (ESRD) patients on hemodialysis (HD) receiving intravenous (IV) iron.	Iron	34-38	transferrin	Homo sapiens	16-27
15979061-1	2005	BACKGROUND: Non-transferrin bound iron (NTBI) has been found to be raised in end stage renal disease (ESRD) patients on hemodialysis (HD) receiving intravenous (IV) iron.	Iron	165-169	transferrin	Homo sapiens	16-27
16190729-5	2005	In the resting form of CYP3A4, a structural water molecule is bound to the sixth coordination position of the heme iron, stabilizing the octahedral coordination geometry.	Iron	115-119	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	23-29
16190729-8	2005	The structural and dynamic features of the CYP3A4-progesterone complex indicate that the oxidative degradation of progesterone occurs through hydroxylation at the C16 position by the reactive oxygen coordinated to the heme iron.	Iron	223-227	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49
16006090-13	2005	Parenteral iron may act by treating a functional iron deficiency and/or by increasing endogenous erythropoietin synthesis.	Iron	11-15	erythropoietin	Homo sapiens	97-111
16168234-2	2005	Dietary iron crosses the enterocyte brush border membrane through the transporter DMT1 after first being reduced by the ferric reductase Dcytb.	Iron	8-12	charged multivesicular body protein 2B	Homo sapiens	82-86
16185154-4	2005	Cancer cells express a large concentration of cell surface transferrin receptors that facilitate uptake of the plasma iron-carrying protein transferrin via endocytosis.	Iron	118-122	transferrin	Homo sapiens	59-70
16185154-4	2005	Cancer cells express a large concentration of cell surface transferrin receptors that facilitate uptake of the plasma iron-carrying protein transferrin via endocytosis.	Iron	118-122	transferrin	Homo sapiens	140-151
16185154-7	2005	Once an artemisinin-tagged transferrin molecule is endocytosed, iron is released and reacts with artemisinin moieties tagged to transferrin.	Iron	64-68	transferrin	Homo sapiens	27-38
16185154-7	2005	Once an artemisinin-tagged transferrin molecule is endocytosed, iron is released and reacts with artemisinin moieties tagged to transferrin.	Iron	64-68	transferrin	Homo sapiens	128-139
15914574-0	2005	Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression.	Iron	19-23	hepcidin antimicrobial peptide	Rattus norvegicus	104-112
15914574-2	2005	AIMS: To assess the effects of 30 days of chronic hypoxia in rats on luminal iron uptake and transfer of the metal to blood, together with gene expression of hepcidin, a proposed negative regulator of iron transport.	Iron	201-205	hepcidin antimicrobial peptide	Rattus norvegicus	158-166
15914574-10	2005	Reduced secretion of hepcidin may be pivotal to the changes in iron absorption.	Iron	63-67	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
16142416-10	2005	Iron stores in untreated IFN-gamma receptor-deficient mice were elevated compared to untreated wild-type mice.	Iron	0-4	interferon gamma	Mus musculus	25-34
16142416-11	2005	After CLP both IFN-gamma receptor-deficient and wild-type mice had equally overloaded iron stores.	Iron	86-90	interferon gamma	Mus musculus	15-24
16187763-6	2005	Furthermore, we show qualitative differences in the distribution of CDKN1A immunofluorescence signals after exposure to X rays, protons or iron ions, suggesting that LET effects likely play a role in the misregulation of gene function in these cells.	Iron	139-143	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-74
16880998-0	2005	Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.	Iron	70-82	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-45
16248829-2	2005	Over the last decade, the production of recombinant human erythropoietin has revolutionized the treatment of anemia associated with chronic renal failure, and has led to a greater understanding of anemia pathophysiology and to the elucidation of the interactions of erythropoietin, iron, and erythropoiesis.	Iron	282-286	erythropoietin	Homo sapiens	58-72
16599026-1	2005	BACKGROUND: Deferiprone (DFP,L1) is a bidentate oral iron chelator which binds to iron in a 3:1 ratio.	Iron	53-57	immunoglobulin kappa variable 1-16	Homo sapiens	25-31
16599026-1	2005	BACKGROUND: Deferiprone (DFP,L1) is a bidentate oral iron chelator which binds to iron in a 3:1 ratio.	Iron	82-86	immunoglobulin kappa variable 1-16	Homo sapiens	25-31
15975770-0	2005	The C2 variant of human serum transferrin retains the iron binding properties of the native protein.	Iron	54-58	transferrin	Homo sapiens	30-41
15901240-9	2005	In conclusion, TNFalpha has a direct effect on small bowel iron transporter expression and function, leading to an inhibition of iron transport.	Iron	59-63	tumor necrosis factor	Homo sapiens	15-23
16300874-7	2005	Iron may also represent a primary factor in the development of RLS, as suggested by recent pathological and brain imaging studies.	Iron	0-4	RLS1	Homo sapiens	63-66
16300874-8	2005	However, the way dopamine and iron, and probably other compounds, interact to generate the circadian pattern in the occurrence of RLS and PLM symptoms remains unknown.	Iron	30-34	RLS1	Homo sapiens	130-133
16200900-3	2005	An adequate iron status is necessary for an optimal epoetin treatment effect.	Iron	12-16	erythropoietin	Homo sapiens	52-59
16200900-9	2005	Forty percent of the epoetin-treated patients had absolute iron deficiency, 60% of whom received iron therapy.	Iron	59-63	erythropoietin	Homo sapiens	21-28
16150724-4	2005	We hypothesize that, by analogy with other carotenoid oxygenases, the predicted iron-coordinating residues of RPE65 are essential for retinoid isomerization.	Iron	80-84	retinal pigment epithelium 65	Mus musculus	110-115
16131073-3	2005	Thus, the present work describes, in the first part, the separation of transferrin isoforms, after iron saturation of the protein, by high-performance liquid chromatography (HPLC) and the on-line specific atomic detection of the iron present on each of the separated isoforms by on-line coupling the HPLC system to an inductively coupled plasma mass spectrometer (ICPMS).	Iron	99-103	transferrin	Homo sapiens	71-82
16131073-3	2005	Thus, the present work describes, in the first part, the separation of transferrin isoforms, after iron saturation of the protein, by high-performance liquid chromatography (HPLC) and the on-line specific atomic detection of the iron present on each of the separated isoforms by on-line coupling the HPLC system to an inductively coupled plasma mass spectrometer (ICPMS).	Iron	229-233	transferrin	Homo sapiens	71-82
15901240-3	2005	The aim of the present study was to examine the local effects of TNFalpha (tumour necrosis factor alpha) on small bowel iron transport and on iron transporter expression in the absence of hepcidin.	Iron	120-124	tumor necrosis factor	Homo sapiens	65-73
15901240-4	2005	The effects of TNFalpha on iron transport were determined using radiolabelled iron in an established Caco-2 cell model.	Iron	27-31	tumor necrosis factor	Homo sapiens	15-23
15901240-6	2005	TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P&lt;0.05).	Iron	45-49	tumor necrosis factor	Homo sapiens	0-8
15901240-6	2005	TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P&lt;0.05).	Iron	61-65	tumor necrosis factor	Homo sapiens	0-8
15886319-5	2005	IL-6 was dramatically induced within 3 hours after injection, and urinary hepcidin peaked within 6 hours, followed by a significant decrease in serum iron.	Iron	150-154	interleukin 6	Homo sapiens	0-4
15886319-7	2005	These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system.	Iron	175-179	interleukin 6	Homo sapiens	58-62
15877545-13	2005	Protein expression of eNOS (endothelial NOS) and iNOS (inducible NOS), and protein nitrotyrosine formation were significantly elevated in cardiac tissue or mitochondrial extraction from the iron-deficient group.	Iron	190-194	nitric oxide synthase 2	Rattus norvegicus	49-53
16183024-4	2005	The trafficking of transferrin-TfR1-PCP complex during the process of transferrin-mediated iron uptake was imaged by fluorescence resonance energy transfer between the fluorescently labeled transferrin ligand and TfR1 receptor.	Iron	91-95	transferrin	Homo sapiens	19-30
16183024-4	2005	The trafficking of transferrin-TfR1-PCP complex during the process of transferrin-mediated iron uptake was imaged by fluorescence resonance energy transfer between the fluorescently labeled transferrin ligand and TfR1 receptor.	Iron	91-95	transferrin	Homo sapiens	70-81
16183024-4	2005	The trafficking of transferrin-TfR1-PCP complex during the process of transferrin-mediated iron uptake was imaged by fluorescence resonance energy transfer between the fluorescently labeled transferrin ligand and TfR1 receptor.	Iron	91-95	transferrin	Homo sapiens	70-81
15877545-13	2005	Protein expression of eNOS (endothelial NOS) and iNOS (inducible NOS), and protein nitrotyrosine formation were significantly elevated in cardiac tissue or mitochondrial extraction from the iron-deficient group.	Iron	190-194	nitric oxide synthase 2	Rattus norvegicus	55-68
15877545-14	2005	Significantly up-regulated NADPH oxidase, caveolin-1 and RhoA expression were also detected in ventricular tissue of the iron-deficient group.	Iron	121-125	caveolin 1	Rattus norvegicus	42-52
16165397-10	2005	CONCLUSIONS: : Combined therapy with IFN-alpha and ribavirin causes an increase in sTfR level with decline in serum iron and ferritin, revealing intracellular reduction of iron stores depending on the result of treatment.	Iron	116-120	interferon alpha 1	Homo sapiens	37-46
16454050-0	2005	[Soluble transferrin receptor-like indicator of iron nutritional status in Venezuelan preschoolers].	Iron	48-52	transferrin	Homo sapiens	9-20
15913932-7	2005	Increased IL-6 production was partially inhibited by treatment of iron (HIF-1 inhibitor) or pyrriolidine-dithiocarbamate (PDTC, NF-kappaB inhibitor).	Iron	66-70	interleukin 6	Homo sapiens	10-14
15913932-7	2005	Increased IL-6 production was partially inhibited by treatment of iron (HIF-1 inhibitor) or pyrriolidine-dithiocarbamate (PDTC, NF-kappaB inhibitor).	Iron	66-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-77
16165397-10	2005	CONCLUSIONS: : Combined therapy with IFN-alpha and ribavirin causes an increase in sTfR level with decline in serum iron and ferritin, revealing intracellular reduction of iron stores depending on the result of treatment.	Iron	172-176	interferon alpha 1	Homo sapiens	37-46
16197231-2	2005	Our results show that a sp2 bonded cap is formed on an iron catalyst, following the diffusion of C atoms from hydrocarbon precursors on the nanoparticle surface.	Iron	55-59	Sp2 transcription factor	Homo sapiens	24-27
16113264-6	2005	Iron-loaded transferrin restored growth to cultures arrested by iron deprivation, whereas apotransferrin was unable to promote growth.	Iron	0-4	transferrin	Homo sapiens	12-23
16113264-6	2005	Iron-loaded transferrin restored growth to cultures arrested by iron deprivation, whereas apotransferrin was unable to promote growth.	Iron	64-68	transferrin	Homo sapiens	12-23
16113264-7	2005	By using congenic strains, we have been able to show that iron uptake by C. albicans from transferrin was mediated by the reductive pathway (via FTR1).	Iron	58-62	transferrin	Homo sapiens	90-101
16113264-9	2005	FRE10 was required for a surface reductase activity and for efficient transferrin iron uptake activity in unbuffered medium.	Iron	82-86	transferrin	Homo sapiens	70-81
16113264-11	2005	Experiments in which transferrin was sequestered in a dialysis bag demonstrated that cell contact with the substrate was required for iron reduction and release.	Iron	134-138	transferrin	Homo sapiens	21-32
16113264-12	2005	The requirement of FTR1 for virulence in a systemic infection model and its role in transferrin iron uptake raise the possibility that transferrin is a source of iron during systemic C. albicans infections.	Iron	96-100	transferrin	Homo sapiens	84-95
16113264-12	2005	The requirement of FTR1 for virulence in a systemic infection model and its role in transferrin iron uptake raise the possibility that transferrin is a source of iron during systemic C. albicans infections.	Iron	96-100	transferrin	Homo sapiens	135-146
16113264-12	2005	The requirement of FTR1 for virulence in a systemic infection model and its role in transferrin iron uptake raise the possibility that transferrin is a source of iron during systemic C. albicans infections.	Iron	162-166	transferrin	Homo sapiens	135-146
16623026-0	2005	Intravenous iron administration during the maintenance period in erythropoietin-treated hemodialysis patients: a simple and effective method.	Iron	12-16	erythropoietin	Homo sapiens	65-79
16623026-1	2005	OBJECTIVES: To determine the interval of intravenous iron administration during maintenance iron therapy in erythropoietin-treated hemodialysis patients.	Iron	53-57	erythropoietin	Homo sapiens	108-122
16623026-8	2005	CONCLUSION: As such, in erythropoietin-treated hemodialysis patients, after loading with 1000 mg, prescription of 100 mg of intravenous iron for every 2 weeks could maintain the TSAT levels above 20%.	Iron	136-140	erythropoietin	Homo sapiens	24-38
16019049-3	2005	Addition of ethanol or an unsaturated fatty acid such as arachidonic acid or iron was toxic to the CYP2E1-expressing cells but not control cells.	Iron	77-81	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	99-105
16019049-5	2005	Apoptosis occurred in the CYP2E1-expressing cells exposed to ethanol, arachidonic acid, or iron.	Iron	91-95	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	26-32
16019049-8	2005	Low concentrations of iron and arachidonic acid synergistically interacted with CYP2E1 to produce cell toxicity, suggesting these nutrients may act as priming or sensitizing agents to alcohol-induced liver injury.	Iron	22-26	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	80-86
15985433-8	2005	We also found a correlation between cytoprotection from iron-mediated damage and efficient incorporation into ferritin of both transferrin and non-transferrin-bound 55Fe.	Iron	56-60	transferrin	Homo sapiens	127-138
15985433-8	2005	We also found a correlation between cytoprotection from iron-mediated damage and efficient incorporation into ferritin of both transferrin and non-transferrin-bound 55Fe.	Iron	56-60	transferrin	Homo sapiens	147-158
16113264-0	2005	Iron acquisition from transferrin by Candida albicans depends on the reductive pathway.	Iron	0-4	transferrin	Homo sapiens	22-33
16113264-2	2005	In humans, free iron is unavailable, being present only in high-affinity iron binding proteins such as transferrin.	Iron	16-20	transferrin	Homo sapiens	103-114
16113264-2	2005	In humans, free iron is unavailable, being present only in high-affinity iron binding proteins such as transferrin.	Iron	73-77	transferrin	Homo sapiens	103-114
16113264-4	2005	Occasionally it invades systemically, and in this circumstance it will encounter transferrin iron.	Iron	93-97	transferrin	Homo sapiens	81-92
16113264-5	2005	Here we report that C. albicans is able to acquire iron from transferrin.	Iron	51-55	transferrin	Homo sapiens	61-72
16315976-6	2005	Iron reducing thermophiles can couple Fe(III) reduction with oxidation of a wide spectrum of organic and inorganic compounds.	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	41-44
15967798-3	2005	Here we show that iron and interleukin-1beta (IL-1beta) act synergistically to increase H- and L-ferritin expression in hepatoma cells.	Iron	18-22	interleukin 1 beta	Homo sapiens	46-54
15967798-8	2005	Iron influx increased the association of alphaCP1 with ferritin mRNA and decreased the alphaCP2-ferritin mRNA interaction, whereas IL-1beta reduced the association of alphaCP1 and alphaCP2 with H-ferritin mRNA.	Iron	0-4	poly(rC) binding protein 1	Homo sapiens	41-49
15967798-8	2005	Iron influx increased the association of alphaCP1 with ferritin mRNA and decreased the alphaCP2-ferritin mRNA interaction, whereas IL-1beta reduced the association of alphaCP1 and alphaCP2 with H-ferritin mRNA.	Iron	0-4	poly(rC) binding protein 2	Homo sapiens	87-95
16085060-2	2005	Previously, we found similar values of affinity constant for the binding of TfR to Tf carrying either Al or Fe.	Iron	108-110	transferrin	Homo sapiens	76-78
16110529-0	2005	Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.	Iron	37-41	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	14-28
16110529-4	2005	Zebrafish grx5 rescued the assembly of grx5 yeast Fe-S, showing that the biochemical function of grx5 is evolutionarily conserved.	Iron	50-54	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	39-43
16085060-0	2005	Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells.	Iron	65-69	transferrin	Homo sapiens	26-37
15870179-1	2005	The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years.	Iron	36-40	transferrin	Homo sapiens	89-100
16085060-1	2005	Aluminum (Al) and iron (Fe) share several physicochemical characteristics and they both bind to transferrin (Tf), entering the cell via Tf receptors (TfR).	Iron	18-22	transferrin	Homo sapiens	96-107
15958384-0	2005	Compensation for a defective interaction of the hsp70 ssq1 with the mitochondrial Fe-S cluster scaffold isu.	Iron	82-86	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	54-58
16085060-1	2005	Aluminum (Al) and iron (Fe) share several physicochemical characteristics and they both bind to transferrin (Tf), entering the cell via Tf receptors (TfR).	Iron	18-22	transferrin	Homo sapiens	109-111
16085060-1	2005	Aluminum (Al) and iron (Fe) share several physicochemical characteristics and they both bind to transferrin (Tf), entering the cell via Tf receptors (TfR).	Iron	24-26	transferrin	Homo sapiens	96-107
16085060-1	2005	Aluminum (Al) and iron (Fe) share several physicochemical characteristics and they both bind to transferrin (Tf), entering the cell via Tf receptors (TfR).	Iron	24-26	transferrin	Homo sapiens	109-111
16085060-6	2005	In turn, Al did induce upregulation of non-Tf bound Fe (NTBI) uptake.	Iron	52-54	transferrin	Homo sapiens	43-45
15958384-1	2005	Ssq1, a specialized yeast mitochondrial Hsp70, plays a critical role in the biogenesis of proteins containing Fe-S clusters through its interaction with Isu, the scaffold on which clusters are built.	Iron	110-114	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	0-4
15958384-4	2005	In contrast, cells expressing Ssq1(V472F), whose affinity for Isu is at least 10-fold lower than that of wild-type Ssq1, had only moderately reduced Fe-S enzyme activities and increased iron levels and grew similarly to wild-type cells.	Iron	149-151	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	30-35
15958384-4	2005	In contrast, cells expressing Ssq1(V472F), whose affinity for Isu is at least 10-fold lower than that of wild-type Ssq1, had only moderately reduced Fe-S enzyme activities and increased iron levels and grew similarly to wild-type cells.	Iron	149-151	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	30-34
15958384-4	2005	In contrast, cells expressing Ssq1(V472F), whose affinity for Isu is at least 10-fold lower than that of wild-type Ssq1, had only moderately reduced Fe-S enzyme activities and increased iron levels and grew similarly to wild-type cells.	Iron	186-190	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	30-35
15958384-4	2005	In contrast, cells expressing Ssq1(V472F), whose affinity for Isu is at least 10-fold lower than that of wild-type Ssq1, had only moderately reduced Fe-S enzyme activities and increased iron levels and grew similarly to wild-type cells.	Iron	186-190	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	30-34
15886332-5	2005	Of the novel phenotypes uncovered, hsp12-Delta and arn1-Delta display increased sensitivity to copper, cyc1-Delta and crr1-Delta show resistance to high copper, vma13-Delta exhibits increased sensitivity to iron deprivation, and pep12-Delta results in reduced growth in high copper and low iron.	Iron	207-211	H(+)-transporting V1 sector ATPase subunit H	Saccharomyces cerevisiae S288C	161-166
15963385-6	2005	Only circulating interleukin-4 (IL-4) and TNF-alpha had abnormal responses with a time association to the oral iron intake.	Iron	111-115	interleukin 4	Homo sapiens	17-30
15963385-6	2005	Only circulating interleukin-4 (IL-4) and TNF-alpha had abnormal responses with a time association to the oral iron intake.	Iron	111-115	interleukin 4	Homo sapiens	32-36
15963385-6	2005	Only circulating interleukin-4 (IL-4) and TNF-alpha had abnormal responses with a time association to the oral iron intake.	Iron	111-115	tumor necrosis factor	Homo sapiens	42-51
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	76-80	transferrin	Homo sapiens	158-169
16080798-0	2005	Iron absorption and oxidant stress during erythropoietin therapy in very low birth weight premature infants: a cohort study.	Iron	0-4	erythropoietin	Homo sapiens	42-56
16080798-2	2005	Our purpose was to examine 1) early supplemental iron during treatment with erythropoietin (EPO) and oxidative stress; 2) enhanced iron absorption during EPO in those infants receiving human milk.	Iron	49-53	erythropoietin	Homo sapiens	92-95
16080798-2	2005	Our purpose was to examine 1) early supplemental iron during treatment with erythropoietin (EPO) and oxidative stress; 2) enhanced iron absorption during EPO in those infants receiving human milk.	Iron	131-135	erythropoietin	Homo sapiens	154-157
16080798-12	2005	CONCLUSION: Data suggest that during erythropoietin therapy antioxidant defence in VLBW infants are capable of dealing with early supplemental iron during treatment with EPO.	Iron	143-147	erythropoietin	Homo sapiens	37-51
16080798-12	2005	CONCLUSION: Data suggest that during erythropoietin therapy antioxidant defence in VLBW infants are capable of dealing with early supplemental iron during treatment with EPO.	Iron	143-147	erythropoietin	Homo sapiens	170-173
16043695-0	2005	HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.	Iron	80-84	S100 calcium binding protein B	Homo sapiens	6-9
16043695-3	2005	We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeostasis and is mutated in the iron-overloading disorder hemochromatosis.	Iron	99-103	S100 calcium binding protein B	Homo sapiens	14-17
16043695-3	2005	We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeostasis and is mutated in the iron-overloading disorder hemochromatosis.	Iron	138-142	S100 calcium binding protein B	Homo sapiens	14-17
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	76-80	transferrin	Homo sapiens	22-24
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	146-150	transferrin	Homo sapiens	158-169
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	146-150	transferrin	Homo sapiens	22-24
15828873-0	2005	Mobilization of the iron centre in IscA for the iron-sulphur cluster assembly in IscU.	Iron	20-24	iron-sulfur cluster assembly enzyme	Homo sapiens	81-85
16133868-0	2005	Intracellular free iron and acidic pathways mediate TNF-induced death of rat hepatoma cells.	Iron	19-23	tumor necrosis factor	Rattus norvegicus	52-55
16133868-8	2005	These data depict a novel mechanism of TNF-mediated cytotoxicity in HTC cells, in which the endo-lysosomal compartment, NADPH oxidase and an iron-mediated pro-oxidant status contribute in determining a caspase-independent, apoptosis-like cell death.	Iron	141-145	tumor necrosis factor	Rattus norvegicus	39-42
16179542-7	2005	The upregulated genes are clustered in cell adhesion/cytoskeleton, extracellular matrix components, cell cycle, protein modification/phosphorylation, protein metabolism and transcription, and inflammation/hypoxia (e.g., key iron and oxygen sensor EGLN1) classes.	Iron	224-228	egl-9 family hypoxia inducible factor 1	Homo sapiens	247-252
15828873-0	2005	Mobilization of the iron centre in IscA for the iron-sulphur cluster assembly in IscU.	Iron	48-52	iron-sulfur cluster assembly enzyme	Homo sapiens	81-85
15831703-9	2005	We postulate that IRP2 mutations or deletions may be a cause of refractory microcytic anemia and bone marrow iron depletion in patients with normal transferrin saturations, elevated serum ferritins, elevated red cell protoporphyrin IX levels, and adult-onset neurodegeneration.	Iron	109-113	iron responsive element binding protein 2	Homo sapiens	18-22
15993339-10	2005	The cytostatic activity of desferal was partially ameliorated by pretreatment with iron-saturated transferrin, and transferrin receptor expression on breast cancer cells nearly doubled after exposure to desferal.	Iron	83-87	transferrin	Homo sapiens	98-109
16152734-2	2005	The effect of IFN-alpha was reversed by the addition of exogenous L-tryptophan and iron to the culture medium, suggesting that antichlamydial effect of IFN-alpha was caused by depletion of intracellular tryptophan and iron, both of which are essential for chlamydial growth.	Iron	83-87	interferon alpha 1	Homo sapiens	14-23
16152734-2	2005	The effect of IFN-alpha was reversed by the addition of exogenous L-tryptophan and iron to the culture medium, suggesting that antichlamydial effect of IFN-alpha was caused by depletion of intracellular tryptophan and iron, both of which are essential for chlamydial growth.	Iron	83-87	interferon alpha 1	Homo sapiens	152-161
16152734-2	2005	The effect of IFN-alpha was reversed by the addition of exogenous L-tryptophan and iron to the culture medium, suggesting that antichlamydial effect of IFN-alpha was caused by depletion of intracellular tryptophan and iron, both of which are essential for chlamydial growth.	Iron	218-222	interferon alpha 1	Homo sapiens	14-23
16152734-2	2005	The effect of IFN-alpha was reversed by the addition of exogenous L-tryptophan and iron to the culture medium, suggesting that antichlamydial effect of IFN-alpha was caused by depletion of intracellular tryptophan and iron, both of which are essential for chlamydial growth.	Iron	218-222	interferon alpha 1	Homo sapiens	152-161
16158226-2	2005	Mutations in DMT1 and Ireg1 have revealed that these molecules are major mediators of iron transport across the brush border and basolateral membranes of the enterocyte, respectively.	Iron	86-90	charged multivesicular body protein 2B	Homo sapiens	13-17
16117851-0	2005	AtbHLH29 of Arabidopsis thaliana is a functional ortholog of tomato FER involved in controlling iron acquisition in strategy I plants.	Iron	96-100	FER-like regulator of iron uptake	Arabidopsis thaliana	0-8
16117851-1	2005	AtbHLH29 of Arabidopsis, encoding a bHLH protein, reveals a high similarity to the tomato FER which is proposed as a transcriptional regulator involved in controlling the iron deficiency responses and the iron uptake in tomato.	Iron	171-175	FER-like regulator of iron uptake	Arabidopsis thaliana	0-8
16117851-6	2005	Our transformation data demonstrate that AtbHLH29 is a functional ortholog of the tomato FER and can completely replace FER in controlling the effective iron acquisition in tomato.	Iron	153-157	FER-like regulator of iron uptake	Arabidopsis thaliana	41-49
16117851-8	2005	Identification of the similar biological functions of FER and AtbHLH29, which isolated from two systematically wide-diverged "strategy I" plants, suggests that FER might be a universal gene presented in all strategy I plants in controlling effective iron acquisition system in roots.	Iron	250-254	FER-like regulator of iron uptake	Arabidopsis thaliana	62-70
16079075-11	2005	Among the elements in the first factor, Fe and Si correlated with IL-6 release, whereas Cr correlated with IL-8 release.	Iron	40-42	interleukin 6	Homo sapiens	66-70
16129039-14	2005	It is concluded that (1) IRP(2) may regulate the iron metabolism in HL-60 cells by altering amounts of the IRP(2) 3.7- or 6.4-kb mRNA at the transcriptional level, or by IRP(2) degradation at the post transcriptional level.	Iron	49-53	iron responsive element binding protein 2	Homo sapiens	25-30
16079117-1	2005	Higher iron stores, reflected by an elevated ferritin concentration and elevated transferrin saturation, can affect glucose intolerance during pregnancy.	Iron	7-11	transferrin	Homo sapiens	81-92
16178374-1	2005	Transferrin, an iron-binding beta-globulin protein that transports iron to mammalian cells, may contribute to innate immunity to fungal pathogens, primarily by limiting microbial access to iron.	Iron	16-20	transferrin	Homo sapiens	0-11
16178374-1	2005	Transferrin, an iron-binding beta-globulin protein that transports iron to mammalian cells, may contribute to innate immunity to fungal pathogens, primarily by limiting microbial access to iron.	Iron	67-71	transferrin	Homo sapiens	0-11
16178374-1	2005	Transferrin, an iron-binding beta-globulin protein that transports iron to mammalian cells, may contribute to innate immunity to fungal pathogens, primarily by limiting microbial access to iron.	Iron	67-71	transferrin	Homo sapiens	0-11
16024802-3	2005	Since we found that TNF-induced LIP in L929 cells is primarily furnished by intracellular storage iron, the lesser induction of LIP in H-ferritin-deficient cells results from a reduction of intracellular iron storage caused by less H-ferritin.	Iron	98-102	tumor necrosis factor	Mus musculus	20-23
16024802-3	2005	Since we found that TNF-induced LIP in L929 cells is primarily furnished by intracellular storage iron, the lesser induction of LIP in H-ferritin-deficient cells results from a reduction of intracellular iron storage caused by less H-ferritin.	Iron	204-208	tumor necrosis factor	Mus musculus	20-23
16024809-0	2005	Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1.	Iron	53-57	Aft2p	Saccharomyces cerevisiae S288C	112-116
16024809-1	2005	The yeast Saccharomyces cerevisiae contains a pair of paralogous iron-responsive transcription activators, Aft1 and Aft2.	Iron	65-69	Aft2p	Saccharomyces cerevisiae S288C	116-120
16024809-3	2005	This study compares the functions of Aft1 and Aft2 in regulating the transcription of genes involved in iron homeostasis, with reference to the presence/absence of the paralog.	Iron	104-108	Aft2p	Saccharomyces cerevisiae S288C	46-50
16024809-5	2005	Aft2 activates the transcription of genes involved in intracellular iron use in the absence of Aft1.	Iron	68-72	Aft2p	Saccharomyces cerevisiae S288C	0-4
16024809-7	2005	Computer analysis found different cis-regulatory elements for Aft1 and Aft2, and transcription analysis using variants of the FET3 promoter indicated that Aft1 is more specific for the canonical iron-responsive element TGCACCC than is Aft2.	Iron	195-199	Aft2p	Saccharomyces cerevisiae S288C	235-239
16024809-8	2005	Finally, the absence of either Aft1 or Aft2 showed an iron-dependent increase in the amount of the remaining paralog.	Iron	54-58	Aft2p	Saccharomyces cerevisiae S288C	39-43
15927492-0	2005	Chronic iron overload enhances inducible nitric oxide synthase expression in rat liver.	Iron	8-12	nitric oxide synthase 2	Rattus norvegicus	31-62
15927492-2	2005	We have tested the hypothesis that chronic iron overload (CIO) enhances inducible nitric oxide synthase (iNOS) expression in rat liver by extracellular signal-regulated kinase (ERK1/2) and NF-kappaB activation.	Iron	43-47	nitric oxide synthase 2	Rattus norvegicus	72-103
15927492-2	2005	We have tested the hypothesis that chronic iron overload (CIO) enhances inducible nitric oxide synthase (iNOS) expression in rat liver by extracellular signal-regulated kinase (ERK1/2) and NF-kappaB activation.	Iron	43-47	nitric oxide synthase 2	Rattus norvegicus	105-109
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	cytochrome b reductase 1	Mus musculus	227-248
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	cytochrome b reductase 1	Mus musculus	250-255
15744772-8	2005	This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption.	Iron	43-47	cytochrome b reductase 1	Mus musculus	193-198
16051393-8	2005	Based on the equilibrium reductions of NO3- and SO4(2-) by Fe0 and mineral precipitation, geochemical modeling predicted a maximum of 49% porosity loss for 5 years of operation.	Iron	59-62	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
16024802-2	2005	Here, using a mutagenesis screen for genes critical in TNF-induced death in L929 cells, we have found that H-ferritin deficiency is responsible for TNF resistance in a mutant line and that, upon treatment with TNF, this line fails to elevate levels of labile iron pool (LIP), critical for TNF-induced reactive oxygen species (ROS) production and ROS-dependent cell death.	Iron	259-263	tumor necrosis factor	Mus musculus	55-58
15964507-7	2005	We have identified specific pathways targeted by endogenous oxidative stress, including glutathione metabolism, iron metabolism, and cell-survival pathways centering on the kinase AKT.	Iron	112-116	thymoma viral proto-oncogene 1	Mus musculus	180-183
16051145-6	2005	The oxidation state of the heme iron also determines whether E75 can interact with its heterodimer partner DHR3, suggesting an additional role as a redox sensor.	Iron	32-36	Hormone receptor 3	Drosophila melanogaster	107-111
16039587-1	2005	Iron regulatory protein 2 (IRP2), a regulator of iron metabolism, is modulated by ubiquitination and degradation.	Iron	49-53	iron responsive element binding protein 2	Homo sapiens	0-25
16039587-1	2005	Iron regulatory protein 2 (IRP2), a regulator of iron metabolism, is modulated by ubiquitination and degradation.	Iron	49-53	iron responsive element binding protein 2	Homo sapiens	27-31
16039587-6	2005	Although HRMs are known to sense heme concentration by simply binding to heme, the HRM in IRP2 specifically contributes to its oxidative modification, its recognition by the ligase, and its sensing of iron concentration after iron is integrated into heme.	Iron	201-205	iron responsive element binding protein 2	Homo sapiens	90-94
16039587-6	2005	Although HRMs are known to sense heme concentration by simply binding to heme, the HRM in IRP2 specifically contributes to its oxidative modification, its recognition by the ligase, and its sensing of iron concentration after iron is integrated into heme.	Iron	226-230	iron responsive element binding protein 2	Homo sapiens	90-94
15998048-0	2005	Effect of ligand structure on the pathways for iron release from human serum transferrin.	Iron	47-51	transferrin	Homo sapiens	77-88
15894800-2	2005	Pre-incubation of SCN- with MPO generates a more complex biological setting, because SCN- serves as either a substrate or inhibitor, causing diverse impacts on the MPO heme iron microenvironment.	Iron	173-177	myeloperoxidase	Homo sapiens	28-31
15894800-2	2005	Pre-incubation of SCN- with MPO generates a more complex biological setting, because SCN- serves as either a substrate or inhibitor, causing diverse impacts on the MPO heme iron microenvironment.	Iron	173-177	myeloperoxidase	Homo sapiens	164-167
15897903-1	2005	In the presence of oxygen and iron, hypoxia-inducible factor (HIF-1alpha) is rapidly degraded via the prolyl hydroxylases (PHD)/VHL pathways.	Iron	30-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
15897903-4	2005	Under hypoxia or low iron (DFX), inhibitors of transcription dramatically super-induced HIF-1alpha.	Iron	21-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-98
15998048-1	2005	Rate constants for the removal of iron from N-terminal monoferric transferrin have been measured for a series of phosphate and phosphonocarboxylic acids in pH 7.4 0.1 M hepes buffer at 25 degrees C. The bidentate ligands pyrophosphate and phosphonoacetic acid (PAA) show a combination of saturation and first-order kinetics with respect to the ligand concentration.	Iron	34-38	transferrin	Homo sapiens	66-77
15976100-7	2005	Stored iron seems to impact negatively on insulin action even in healthy people, and not just in classic pathologic conditions associated with iron overload (hemochromatosis and hemosiderosis).	Iron	7-11	insulin	Homo sapiens	42-49
16000623-5	2005	In the presence of elevated iron concentrations, as observed in PD, increased cytosolic dopamine led to oxidative stress, c-Jun N-terminal kinase (JNK) pathway activation, neurite degeneration, and eventually apoptosis.	Iron	28-32	mitogen-activated protein kinase 8	Homo sapiens	122-145
16000623-5	2005	In the presence of elevated iron concentrations, as observed in PD, increased cytosolic dopamine led to oxidative stress, c-Jun N-terminal kinase (JNK) pathway activation, neurite degeneration, and eventually apoptosis.	Iron	28-32	mitogen-activated protein kinase 8	Homo sapiens	147-150
15749737-6	2005	Most of the iron taken up by the cells is then released into the medium within 8 h in the form of less reactive protein-bound complexes including ferritin and transferrin.	Iron	12-16	transferrin	Homo sapiens	159-170
15749739-8	2005	Finally, iron transport into BEAS-2B cells was increased after inclusion of TNF-alpha, IFN-gamma, or LPS in the media.	Iron	9-13	tumor necrosis factor	Homo sapiens	76-85
15749739-8	2005	Finally, iron transport into BEAS-2B cells was increased after inclusion of TNF-alpha, IFN-gamma, or LPS in the media.	Iron	9-13	interferon gamma	Homo sapiens	87-96
15932798-5	2005	The molecular details of the connection between iron metabolism, hepcidin and inflammation have become clearer with the recent finding of hepcidin-induced internalization and degradation of FPN1.	Iron	48-52	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	190-194
15925514-6	2005	The time course of Co uptake from cells incubated with Co-Tf showed an initial rapid association with cells, then a slower rate of accumulation, that is, a similar uptake profile to that of iron.	Iron	190-194	transferrin	Homo sapiens	58-60
16000801-7	2005	The FRE1 gene complemented the phenotype of S. cerevisiae Deltafre1 cells, restoring the ability to grow in medium without externally added iron and to decolorize the dye, following a pattern similar to the one observed in the wild-type strain.	Iron	140-144	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	4-8
15880142-1	2005	The enzyme heme oxygenase-1 (HO-1) is a cytoprotective and anti-inflammatory protein that degrades heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide (CO).	Iron	137-149	heme oxygenase 1	Mus musculus	11-27
15880142-1	2005	The enzyme heme oxygenase-1 (HO-1) is a cytoprotective and anti-inflammatory protein that degrades heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide (CO).	Iron	137-149	heme oxygenase 1	Mus musculus	29-33
16164836-4	2005	Blood plasma transferrin is a major carrier of blood iron essential for proliferative "emergency" response of hematopoietic and immune systems as well as injured tissue in major trauma.	Iron	53-57	transferrin	Rattus norvegicus	13-24
16212172-4	2005	The Fe, Al-P was the largest component in all the P-forms and the content of ammonium nitrogen in these two bays less than that of other lakes.	Iron	4-6	N-acetyltransferase 10	Homo sapiens	8-12
16081371-4	2005	It has been proposed that the level of circulating diferric transferrin, which reflects tissue iron levels, acts as a signal to alter hepcidin expression.	Iron	95-99	transferrin	Homo sapiens	60-71
15917335-8	2005	Increased Fe(PO4) was associated with decreased eGFR, and both increased FGF-23 and PTH were independently associated with increased Fe(PO4).	Iron	133-135	parathyroid hormone	Homo sapiens	84-87
15975131-10	2005	Indium, molybdenum and iron induced twofold IL-1beta levels compared with untreated control cultures.	Iron	23-27	interleukin 1 beta	Homo sapiens	44-52
15672419-0	2005	Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake.	Iron	123-127	transferrin	Homo sapiens	92-103
15672419-5	2005	Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate.	Iron	70-74	transferrin	Homo sapiens	109-120
15672419-5	2005	Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate.	Iron	186-190	transferrin	Homo sapiens	109-120
16000716-8	2005	Additional analyses using PAO1 strains that carry lacZ fusions with the toxA regulatory genes regA and pvdS revealed that the expression of regA and pvdS is reduced rather than increased at 0%-ST. ptxR expression under different conditions paralleled that of toxA expression, except that it was repressed by iron under 20 %-SH only.	Iron	308-312	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	197-201
16000726-9	2005	IroC mediated the uptake of iron via enterobactin in a fepB mutant.	Iron	28-32	IroC	Escherichia coli	0-4
16024827-8	2005	New methods for quantifying non-transferrin-bound (or labile plasma) iron may help in the future to identify patients at risk for toxicity from excess iron supplementation.	Iron	69-73	transferrin	Homo sapiens	32-43
15998312-1	2005	Ferritins are multimeric iron storage proteins encoded by a four-member gene family in Arabidopsis (AtFer1-4).	Iron	25-29	ferretin 1	Arabidopsis thaliana	100-108
15998312-6	2005	was independent of the iron-dependent regulatory sequence (IDRS) known to mediate the transcriptional response of the AtFer1 gene to iron excess and to nitric oxide.	Iron	133-137	ferretin 1	Arabidopsis thaliana	118-124
15988320-2	2005	Transferrin, an acute-phase N-glycosylated glycoprotein, plays an important role in iron transport.	Iron	84-88	transferrin	Homo sapiens	0-11
15988320-4	2005	The hepatic uptake of iron is greater for desialylated transferrin isoforms (disialotransferrin) than for the other forms.	Iron	22-26	transferrin	Homo sapiens	55-66
15973703-1	2005	The recently identified acute-phase response antimicrobial peptide hepcidin has been postulated to maintain iron homeostasis by modulating iron absorption at both the intestinal and macrophage levels.	Iron	108-112	hepcidin antimicrobial peptide	Rattus norvegicus	67-75
15973703-1	2005	The recently identified acute-phase response antimicrobial peptide hepcidin has been postulated to maintain iron homeostasis by modulating iron absorption at both the intestinal and macrophage levels.	Iron	139-143	hepcidin antimicrobial peptide	Rattus norvegicus	67-75
15973703-3	2005	Since Kupffer cells are known to be the primary contributor to early-phase ischemia-reperfusion injury in the liver and iron is known to modulate Kupffer cell production of proinflammatory cytokine and reactive oxygen species, we investigated hepcidin in vivo expression in the well-established rat partial-liver ischemia-reperfusion model.	Iron	120-124	hepcidin antimicrobial peptide	Rattus norvegicus	243-251
15995033-8	2005	During GH therapy, an increase in serum transferrin (56.5 +/- 35.2 mg/dL) and a decrease in serum iron (20.5.5 +/- 20.2 microg/dL) were noted.	Iron	98-102	growth hormone 1	Homo sapiens	7-9
15956209-2	2005	Most patients develop iron loading of Kupffer cells with relatively low saturation of plasma transferrin, but others present with high transferrin saturation and iron-loaded hepatocytes.	Iron	22-26	transferrin	Homo sapiens	93-104
15994221-6	2005	The pathophysiology of primary RLS is associated with dopaminergic dysfunction and abnormal brain iron metabolism.	Iron	98-102	RLS1	Homo sapiens	31-34
15817488-7	2005	Iron-induced degradation of Fet3p-Ftr1p is significantly reduced in strains containing a deletion of a gene, VTA1, which is involved in multivesicular body (MVB) sorting in yeast.	Iron	0-4	Vta1p	Saccharomyces cerevisiae S288C	109-113
15907869-0	2005	Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform.	Iron	94-98	transferrin	Homo sapiens	76-87
15907869-1	2005	Non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload.	Iron	22-26	transferrin	Homo sapiens	4-15
15907869-1	2005	Non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload.	Iron	78-82	transferrin	Homo sapiens	4-15
15924420-0	2005	Mutational analysis of C-lobe ligands of human serum transferrin: insights into the mechanism of iron release.	Iron	97-101	transferrin	Homo sapiens	53-64
15924420-12	2005	The differences in the effects of mutating the liganding residues in the two lobes and the subtle indications of cooperativity between lobes point to the importance of the transferrin receptor in effecting iron release from the C-lobe.	Iron	206-210	transferrin	Homo sapiens	172-183
15897780-7	2005	Intracellular iron chelation with D-Exo directly inhibits endothelial cell growth but indirectly stimulates endothelial cell growth by increasing VEGF release by VSMCs.	Iron	14-18	vascular endothelial growth factor A	Homo sapiens	146-150
15917333-2	2005	Here, we have characterized Grx2 as an iron-sulfur center-containing member of the thioredoxin fold protein family.	Iron	39-43	glutaredoxin 2	Homo sapiens	28-32
15917333-4	2005	Coimmunoprecipitation of radiolabeled iron with Grx2 from human cell lines indicated the presence of the cluster in vivo.	Iron	38-42	glutaredoxin 2	Homo sapiens	48-52
15917333-7	2005	We propose that the iron-sulfur cluster serves as a redox sensor for the activation of Grx2 during conditions of oxidative stress when free radicals are formed and the glutathione pool becomes oxidized.	Iron	20-24	glutaredoxin 2	Homo sapiens	87-91
15737890-1	2005	Labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox-active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	14-18	transferrin	Homo sapiens	55-66
15737890-1	2005	Labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox-active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	73-77	transferrin	Homo sapiens	55-66
15737890-1	2005	Labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox-active and chelatable, capable of permeating into organs and inducing tissue iron overload.	Iron	73-77	transferrin	Homo sapiens	55-66
15737895-0	2005	Iron requirements in erythropoietin therapy.	Iron	0-4	erythropoietin	Homo sapiens	21-35
15737895-1	2005	When erythropoietin (epoetins or darbepoetin) is used to treat the anemias of chronic renal failure, cancer chemotherapy, inflammatory bowel diseases, HIV infection and rheumatoid arthritis, functional iron deficiency rapidly ensues unless individuals are iron-overloaded from prior transfusions.	Iron	202-206	erythropoietin	Homo sapiens	5-19
15737895-2	2005	Therefore, iron therapy is essential when using erythropoietin to maximize erythropoiesis by avoiding absolute and functional iron deficiency.	Iron	11-15	erythropoietin	Homo sapiens	48-62
15737895-4	2005	There is no ideal method for monitoring iron therapy, but serum ferritin and transferrin iron saturation are the most common tests.	Iron	89-93	transferrin	Homo sapiens	77-88
15938725-0	2005	Evaluation of serum transferrin receptor assay in a centralized iron screening service.	Iron	64-68	transferrin	Homo sapiens	20-31
15671444-1	2005	Labile plasma iron (LPI) represents the redox active component of non-transferrin-bound iron (NTBI).	Iron	14-18	transferrin	Homo sapiens	70-81
15671444-1	2005	Labile plasma iron (LPI) represents the redox active component of non-transferrin-bound iron (NTBI).	Iron	88-92	transferrin	Homo sapiens	70-81
15671444-9	2005	Transferrin saturation above 75% was related to iron overload in GH and to liver failure in alcoholic cirrhosis.	Iron	48-52	transferrin	Homo sapiens	0-11
15917086-2	2005	The non-heme iron in the enzyme (Fe(III) as isolated) is 6-coordinated to a 2-His-1-carboxylate motif and three water molecules (wat1, wat2 and wat3).	Iron	13-17	MTOR associated protein, LST8 homolog	Homo sapiens	129-133
15902304-0	2005	Ferroportin1 is required for normal iron cycling in zebrafish.	Iron	36-40	solute carrier family 40 member 1	Danio rerio	0-12
15902304-1	2005	Missense mutations in ferroportin1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane helices 3 and 4 in the zebrafish anemia mutant weissherbst (weh(Tp85c-/-)) and in patients with type 4 hemochromatosis.	Iron	72-76	solute carrier family 40 member 1	Danio rerio	22-34
15902304-1	2005	Missense mutations in ferroportin1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane helices 3 and 4 in the zebrafish anemia mutant weissherbst (weh(Tp85c-/-)) and in patients with type 4 hemochromatosis.	Iron	72-76	solute carrier family 40 member 1	Danio rerio	36-40
15902304-7	2005	Injection of iron dextran into WT or mutant zebrafish embryos, however, resulted in significant increases in hepcidin expression 18 hours after injection, demonstrating that hepcidin expression in zebrafish is iron responsive and independent of fpn1"s function as an iron exporter.	Iron	13-17	solute carrier family 40 member 1	Danio rerio	245-249
16110751-7	2005	It is still necessary to further explore the real need of iron supplementation to maintain adequate erythropoiesis prior and during epoetin therapy.	Iron	58-62	erythropoietin	Homo sapiens	132-139
15917086-15	2005	All together, our results support that the mutation Y325L causes the removal or increased delocalization of the iron-ligated wat1 and, in turn, a less tight binding of the metal.	Iron	112-116	MTOR associated protein, LST8 homolog	Homo sapiens	125-129
15974627-2	2005	Compounds 1, 2, and 4 inhibited both hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha protein accumulation.	Iron	50-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-77
15880490-7	2005	However, rat pups with decreased iron and CO exposure (ARIDCO) exhibited in their cochlea an up-regulation of transferrin, whereas their expression of neurofilament proteins and SOD1 were similar to control.	Iron	33-37	transferrin	Rattus norvegicus	110-121
15885310-2	2005	The iron-chelator desferrioxamine (DFX) increased the expression of hypoxia-inducible factor (HIF)-1alpha in the hair cell line, HEI-OC1.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	68-105
15885310-3	2005	The increased VEGF production by DFX was inhibited by iron.	Iron	54-58	vascular endothelial growth factor A	Homo sapiens	14-18
15974627-2	2005	Compounds 1, 2, and 4 inhibited both hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha protein accumulation.	Iron	50-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
15848143-1	2005	Lipoxygenases contain prosthetic iron, in human 5-lipoxygenase (5LO) the C-terminal isoleucine carboxylate constitutes one of five identified ligands.	Iron	33-37	arachidonate 5-lipoxygenase	Homo sapiens	48-62
15815978-0	2005	Structural characterization of an iron-sulfur cluster assembly protein IscU in a zinc-bound form.	Iron	34-38	iron-sulfur cluster assembly enzyme	Homo sapiens	71-75
15966996-21	2005	Regular low-dose iron improves the response to epoetin and lowers the dose of epoetin, even in cases when the intravenously administration route is used.	Iron	17-21	erythropoietin	Homo sapiens	47-54
15966996-21	2005	Regular low-dose iron improves the response to epoetin and lowers the dose of epoetin, even in cases when the intravenously administration route is used.	Iron	17-21	erythropoietin	Homo sapiens	78-85
15845361-9	2005	The expressed isoform was found to promote cell survival under iron-deficient conditions and blocked the cleavage of poly(ADP-ribose) polymerase.	Iron	63-67	poly(ADP-ribose) polymerase 1	Homo sapiens	117-144
15923604-6	2005	The p38alpha-/- cells are able to activate HIF-1 in response to anoxia or iron chelators during normoxia.	Iron	74-78	mitogen-activated protein kinase 14	Homo sapiens	4-12
15923604-6	2005	The p38alpha-/- cells are able to activate HIF-1 in response to anoxia or iron chelators during normoxia.	Iron	74-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
15878351-6	2005	We used the iron chelator desferrioxamine (DFX) or hypoxia to accumulate HIF-1alpha in HEK293 cells.	Iron	12-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
15767258-0	2005	Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis.	Iron	85-89	Fe(2+) transporter	Saccharomyces cerevisiae S288C	45-50
15767258-9	2005	The Mrs3/4p carriers were required for rapid iron transport into mitochondria for heme synthesis, whereas there was also evidence for an alternative slower system.	Iron	45-49	Fe(2+) transporter	Saccharomyces cerevisiae S288C	4-8
15885407-3	2005	Under oxic conditions, arsenate [As(V)] removal by Fe(0) filings was faster than arsenite [As(III)].	Iron	51-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-38
15538748-6	2005	Increased expression of the P582S mutant induced by iron chelation, which blocks proline hydroxylation of wild-type HIF-1alpha, was markedly attenuated.	Iron	52-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
15565311-0	2005	MR relaxometry and 1H MR spectroscopy for the determination of iron and metabolite concentrations in PKAN patients.	Iron	63-67	pantothenate kinase 2	Homo sapiens	101-105
15843062-1	2005	Pantothenate kinase-associated neurodegeneration (PKAN) may serve as a model for Parkinson disease (PD) since many PKAN patients suffer from parkinsonism and both conditions lead to iron accumulation in the basal ganglia.	Iron	182-186	pantothenate kinase 2	Homo sapiens	0-55
15843062-1	2005	Pantothenate kinase-associated neurodegeneration (PKAN) may serve as a model for Parkinson disease (PD) since many PKAN patients suffer from parkinsonism and both conditions lead to iron accumulation in the basal ganglia.	Iron	182-186	pantothenate kinase 2	Homo sapiens	50-54
15626777-0	2005	Role of iron in inactivation of epidermal growth factor receptor after asbestos treatment of human lung and pleural target cells.	Iron	8-12	epidermal growth factor receptor	Homo sapiens	32-64
15626777-8	2005	Removal of iron from asbestos by desferrioxamine B or phytic acid inhibited asbestos-induced decreases in EGFR phosphorylation.	Iron	11-15	epidermal growth factor receptor	Homo sapiens	106-110
15626777-9	2005	The effects of crocidolite, amosite, and chrysotile on the EGFR phosphorylation state appeared to be directly related to the amount of iron mobilized from these fibers.	Iron	135-139	epidermal growth factor receptor	Homo sapiens	59-63
15626777-10	2005	These results strongly suggest that iron plays an important role in asbestos-induced inactivation of EGFR.	Iron	36-40	epidermal growth factor receptor	Homo sapiens	101-105
16477936-7	2005	The main dissolved trace metals in fog droplets are Zn, Al and Fe, while the main metallic cations are Na and Ca.	Iron	63-65	zinc finger protein, FOG family member 1	Homo sapiens	35-38
16477936-8	2005	Fe and Al are the only metals preferentially distributed in the suspended insoluble matter of fog droplets (partitioning ratio respectively 37% and 33%).	Iron	0-2	zinc finger protein, FOG family member 1	Homo sapiens	94-97
16477936-13	2005	The partitioning ratio of iron (mean 37%) observed in the Po Valley fog samples is much higher than the water extractable iron in aerosol particles (typically 1-2 %): this fact can be explained by differences in the aerosol sources and composition among sites and by chemical processes in the aqueous phase, such as complexation and redox reactions involving organic ligands (oxalate, or other organic acids as humic-like organic matter) which may promote Fe solubility.	Iron	26-30	zinc finger protein, FOG family member 1	Homo sapiens	68-71
15894659-2	2005	Cellular iron uptake is regulated by the hemochromatosis and transferrin receptor system, mutations of which cause the iron storage disease hereditary hemochromatosis.	Iron	9-13	transferrin	Homo sapiens	61-72
15894659-2	2005	Cellular iron uptake is regulated by the hemochromatosis and transferrin receptor system, mutations of which cause the iron storage disease hereditary hemochromatosis.	Iron	119-123	transferrin	Homo sapiens	61-72
15845371-1	2005	Aryl hydrocarbon receptor ligands, such as polychlorinated biphenyls (PCBs), cause inhibition of the heme biosynthesis enzyme, uroporphyrinogen decarboxylase; this leads to uroporphyria and hepatic tumors, which are markedly enhanced by iron overload in C57BL/10 and C57BL/6 strains of mice.	Iron	237-241	aryl-hydrocarbon receptor	Mus musculus	0-25
15849819-7	2005	The induction of hepatic microsomal cytochrome P450 2E1 (CYP2E1) was obviously seen in group ME and group FE, but was not detected in group MC and group FC.	Iron	106-108	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	36-55
15849819-7	2005	The induction of hepatic microsomal cytochrome P450 2E1 (CYP2E1) was obviously seen in group ME and group FE, but was not detected in group MC and group FC.	Iron	106-108	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	57-63
15847411-7	2005	The presence of the phenolate moieties in the quadridentate hetero-donor tripodal ligands, H3L, lends these iron(III) ternary complexes the potential to model the specific metal-coordination, metal-substrate interactions, and physicochemical behaviors of several iron-tyrosinate proteins.	Iron	108-112	H3 clustered histone 2	Homo sapiens	91-94
15847411-7	2005	The presence of the phenolate moieties in the quadridentate hetero-donor tripodal ligands, H3L, lends these iron(III) ternary complexes the potential to model the specific metal-coordination, metal-substrate interactions, and physicochemical behaviors of several iron-tyrosinate proteins.	Iron	263-267	H3 clustered histone 2	Homo sapiens	91-94
16511074-4	2005	Whereas IRP2 is known to be involved in Fe homeostasis, the role of IRP1 is less clear; it may provide a link between citrate and iron metabolisms and be involved in oxidative stress response.	Iron	40-42	iron responsive element binding protein 2	Homo sapiens	8-12
15860357-2	2005	The purpose of this study was to assess the likelihood that variation in the SLC11A1 gene contributes to EC susceptibility, possibly due to its role in inflammation and iron metabolism.	Iron	169-173	solute carrier family 11 member 1	Homo sapiens	77-84
15708449-0	2005	Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain.	Iron	18-22	solute carrier family 11 member 2	Rattus norvegicus	70-98
15853810-1	2005	NMR and visible spectroscopy coupled to redox measurements were used to determine the equilibrium thermodynamic properties of the four haems in cytochrome c3 under conditions in which the protein was bound to ligands, the small anion phosphate and the protein rubredoxin with the iron in the active site replaced by zinc.	Iron	280-284	cytochrome c, somatic	Homo sapiens	144-156
15793843-7	2005	Our results show that iron is able to induce hepcidin gene expression independently of Kupffer cells in the liver and circulating IL-6.	Iron	22-26	interleukin 6	Mus musculus	130-134
15861017-4	2005	Folic acid concentration was subnormal in 31% of the CD subjects (versus 14% of the controls) and iron status (transferrin receptor-ferritin index) was subnormal in 30% (versus 14%).	Iron	98-102	transferrin	Homo sapiens	111-122
15973347-6	2005	Only serum transferrin was significantly different following the 30-day administration of iron supplementation.	Iron	90-94	transferrin	Homo sapiens	11-22
15879678-1	2005	Lactoferrin, a member of the transferrin family, is iron-binding and a strongly cationic 76 kDa glycoprotein.	Iron	52-56	transferrin	Homo sapiens	29-40
15708449-2	2005	The cellular localization and functional characterization of DMT1 suggest that it might play a role in physiological iron transport in the brain.	Iron	117-121	solute carrier family 11 member 2	Rattus norvegicus	61-65
16566123-2	2005	It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion.	Iron	24-28	Fet4p	Saccharomyces cerevisiae S288C	144-148
16161954-10	2005	CONCLUSIONS: Elevated serum iron, ferritin levels and iron transferrin saturations in subjects with chronic hepatitis C has been noted nearly in a half of examined patients.	Iron	54-58	transferrin	Homo sapiens	59-70
15913703-8	2005	In the top portion of the column, the dissolved iron present in ground water is oxidized by atmospheric oxygen into hydrated Fe(III) oxides or HFO particles which in turn selectively bind both As(III) and As(V).	Iron	48-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	205-210
16566123-2	2005	It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion.	Iron	179-183	Fet4p	Saccharomyces cerevisiae S288C	144-148
15921722-0	2005	Photodegradation of DDT with the photodeposited ferric ion on the TiO2 film.	Iron	48-58	D-dopachrome tautomerase	Homo sapiens	20-23
15604307-0	2005	Administration of ANG II induces iron deposition and upregulation of TGF-beta1 mRNA in the rat liver.	Iron	33-37	angiotensinogen	Rattus norvegicus	18-24
15921722-1	2005	The photodegradation capability of DDT has been enhanced by Fe/TiO2 film in a photoreactor with UV radiation.	Iron	60-62	D-dopachrome tautomerase	Homo sapiens	35-38
15705575-5	2005	One iron-binding site was determined for mTf with similar binding characteristics to other transferrins.	Iron	4-8	melanotransferrin	Mus musculus	41-44
15705575-8	2005	This affinity is intermediate between the high and low affinity lobes of transferrin and suggests that mTf is likely to play a significant role in iron transport where the high affinity lobe of transferrin is occupied or where transferrin is in proportionally low concentrations.	Iron	147-151	transferrin	Homo sapiens	73-84
15705575-8	2005	This affinity is intermediate between the high and low affinity lobes of transferrin and suggests that mTf is likely to play a significant role in iron transport where the high affinity lobe of transferrin is occupied or where transferrin is in proportionally low concentrations.	Iron	147-151	melanotransferrin	Mus musculus	103-106
15705575-8	2005	This affinity is intermediate between the high and low affinity lobes of transferrin and suggests that mTf is likely to play a significant role in iron transport where the high affinity lobe of transferrin is occupied or where transferrin is in proportionally low concentrations.	Iron	147-151	transferrin	Homo sapiens	194-205
15705575-8	2005	This affinity is intermediate between the high and low affinity lobes of transferrin and suggests that mTf is likely to play a significant role in iron transport where the high affinity lobe of transferrin is occupied or where transferrin is in proportionally low concentrations.	Iron	147-151	transferrin	Homo sapiens	194-205
15837926-3	2005	Here we present the 3.5-A crystal structure of the PSMA ectodomain, which reveals a homodimer with structural similarity to transferrin receptor, a receptor for iron-loaded transferrin that lacks protease activity.	Iron	161-165	folate hydrolase 1	Homo sapiens	51-55
15837926-3	2005	Here we present the 3.5-A crystal structure of the PSMA ectodomain, which reveals a homodimer with structural similarity to transferrin receptor, a receptor for iron-loaded transferrin that lacks protease activity.	Iron	161-165	transferrin	Homo sapiens	124-135
15796505-2	2005	While PDF was originally thought to be a zinc enzyme, subsequent studies revealed that the active site metal is iron.	Iron	112-116	peptide deformylase	Escherichia coli	6-9
15796505-8	2005	On the basis of these structures, we propose that the basis for the higher activity of Fe-PDF stems from the better ability of iron to bind and activate the tetrahedral transition state required for cleavage of the N-terminal formyl group.	Iron	127-131	peptide deformylase	Escherichia coli	90-93
16054986-4	2005	One cellular consequence of sustained oxidative stress and redox imbalance resulting from the combined actions of alcohol and iron is lipid peroxidation, resulting in the production of aldehydic products such as 4-hydroxy-2-nonenal, which has been linked to site-specific mutations of the p53 gene.	Iron	126-130	tumor protein p53	Homo sapiens	289-292
16054986-5	2005	In addition, the accumulation of iron in hepatic macrophage isolated from laboratory animals chronically ingesting alcohol is associated with activation of nuclear factor-kappa B and production of tumor necrosis factor-alpha, providing a proinflammatory cellular environment also favorable for initiation and promotion of carcinogenesis.	Iron	33-37	tumor necrosis factor	Homo sapiens	197-224
15795917-3	2005	The most frequent indications for parenteral iron therapy are unbearable gastrointestinal side effects induced by oral iron itself, worsening of inflammatory bowel disease symptoms, insufficient intestinal absorption, renal failure-caused anemia that is treated with erythropoietin, and unresolved ongoing bleeding, which would cause the acceptable oral doses of iron therapy to be exceeded.	Iron	45-49	erythropoietin	Homo sapiens	267-281
15839648-1	2005	The physiological electron-transfer (ET) partners, cytochrome c peroxidase (CcP) and cytochrome c (Cc)1, can be modified to exhibit photoinitiated ET through substitution of Zn (or Mg) for Fe in either partner.	Iron	189-191	cytochrome c, somatic	Homo sapiens	51-63
15878745-3	2005	Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter, DMT1 (Slc11a2), and the Transferrin Receptor (TfR).	Iron	25-29	solute carrier family 11 member 2	Rattus norvegicus	110-114
15878745-3	2005	Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter, DMT1 (Slc11a2), and the Transferrin Receptor (TfR).	Iron	25-29	solute carrier family 11 member 2	Rattus norvegicus	116-123
15806612-6	2005	Present experiments demonstrate that Ure2 possesses a far broader protection specificity, being required to avoid the toxic effects of As(III), As(V), Cr(III), Cr(VI), Se(IV), as well as Cd(II) and Ni(II), and to varying lesser degrees Co(II), Cu(II), Fe(II), Ag(I), Hg(II), cumene and t-butyl hydroperoxides.	Iron	252-254	glutathione peroxidase	Saccharomyces cerevisiae S288C	37-41
15792874-6	2005	UV irradiation (365 nm) of solutions containing DNDI and the redox protein cytochrome c (cyt c) resulted in the reduction of the heme iron from the Fe(III) to the Fe(II) state, a reaction that was inhibited by the incorporation of DNDI into CTAB micelles.	Iron	134-138	cytochrome c, somatic	Homo sapiens	75-87
15792874-6	2005	UV irradiation (365 nm) of solutions containing DNDI and the redox protein cytochrome c (cyt c) resulted in the reduction of the heme iron from the Fe(III) to the Fe(II) state, a reaction that was inhibited by the incorporation of DNDI into CTAB micelles.	Iron	134-138	cytochrome c, somatic	Homo sapiens	89-94
15550525-0	2005	Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart.	Iron	0-4	angiotensinogen	Rattus norvegicus	53-67
15550525-0	2005	Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart.	Iron	0-4	transforming growth factor, beta 1	Rattus norvegicus	92-101
15550525-2	2005	We previously found iron deposition in the heart of the angiotensin II-infused rat, which may promote angiotensin II-induced cardiac damage.	Iron	20-24	angiotensinogen	Rattus norvegicus	56-70
15550525-2	2005	We previously found iron deposition in the heart of the angiotensin II-infused rat, which may promote angiotensin II-induced cardiac damage.	Iron	20-24	angiotensinogen	Rattus norvegicus	102-116
15550525-8	2005	These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1.	Iron	40-44	angiotensinogen	Rattus norvegicus	123-137
15550525-8	2005	These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1.	Iron	40-44	transforming growth factor, beta 1	Rattus norvegicus	209-218
15550525-8	2005	These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1.	Iron	53-57	angiotensinogen	Rattus norvegicus	123-137
15550525-8	2005	These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1.	Iron	53-57	transforming growth factor, beta 1	Rattus norvegicus	209-218
15604307-1	2005	We previously found that ANG II infusion into rats causes iron deposition in the kidney and heart, which may have a role in the regulation of profibrotic gene expression and tissue fibrosis.	Iron	58-62	angiotensinogen	Rattus norvegicus	25-31
15604307-2	2005	In the present study, we have investigated whether ANG II can also induce iron accumulation in the liver.	Iron	74-78	angiotensinogen	Rattus norvegicus	51-57
15604307-4	2005	Immunohistochemical and histological analyses showed that some iron-positive nonparenchymal cells were positive for ferritin and heme oxygenase-1 (HO-1) protein and TGF-beta1 mRNA and were judged to be monocytes/macrophages.	Iron	63-67	transforming growth factor, beta 1	Rattus norvegicus	165-174
15604307-7	2005	Taken together, our data suggest that ANG II infusion induces aberrant iron homeostasis in the liver, which may have a role in the ANG II-induced upregulation of profibrotic gene expression in the liver.	Iron	71-75	angiotensinogen	Rattus norvegicus	38-44
15604307-7	2005	Taken together, our data suggest that ANG II infusion induces aberrant iron homeostasis in the liver, which may have a role in the ANG II-induced upregulation of profibrotic gene expression in the liver.	Iron	71-75	angiotensinogen	Rattus norvegicus	131-137
15703274-8	2005	Cardiomyocyte hypertrophy and ERK activation were also inhibited by decreasing intracellular ROS by adenoviral overexpression of catalase or cardiomyocytes treatment with the iron chelator deferoxamine.	Iron	175-179	catalase	Rattus norvegicus	129-137
15801969-0	2005	Iron mobilisation from transferrin by deferiprone (L1).	Iron	0-4	transferrin	Homo sapiens	23-34
15921034-0	2005	Gallium-inducible transferrin-independent iron acquisition is a property of many cell types: possible role of alterations in the plasma membrane.	Iron	42-46	transferrin	Homo sapiens	18-29
15794760-2	2005	Human serum transferrin (Tf) is one of the major iron carriers in charge of iron regulation in the cell cycle and consequently contamination by actinide cations is a critical issue of nuclear toxicology.	Iron	49-53	transferrin	Homo sapiens	12-23
15794760-2	2005	Human serum transferrin (Tf) is one of the major iron carriers in charge of iron regulation in the cell cycle and consequently contamination by actinide cations is a critical issue of nuclear toxicology.	Iron	49-53	transferrin	Homo sapiens	25-27
15794760-2	2005	Human serum transferrin (Tf) is one of the major iron carriers in charge of iron regulation in the cell cycle and consequently contamination by actinide cations is a critical issue of nuclear toxicology.	Iron	76-80	transferrin	Homo sapiens	12-23
15794760-2	2005	Human serum transferrin (Tf) is one of the major iron carriers in charge of iron regulation in the cell cycle and consequently contamination by actinide cations is a critical issue of nuclear toxicology.	Iron	76-80	transferrin	Homo sapiens	25-27
15803024-2	2005	The products of heme catalysis, biliverdin/bilirubin, carbon monoxide (CO), and iron (that induces apoferritin) mediate the beneficial effects of HO-1.	Iron	80-84	heme oxygenase 1	Mus musculus	146-150
15880095-0	2005	Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron.	Iron	43-47	transferrin	Homo sapiens	125-136
15880095-0	2005	Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron.	Iron	143-147	transferrin	Homo sapiens	125-136
15880095-1	2005	Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophore- and transferrin-binding protein (named IsdA)-mediated iron-acquisition systems.	Iron	76-80	transferrin	Homo sapiens	58-69
15880095-1	2005	Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophore- and transferrin-binding protein (named IsdA)-mediated iron-acquisition systems.	Iron	76-80	transferrin	Homo sapiens	108-119
15880095-1	2005	Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophore- and transferrin-binding protein (named IsdA)-mediated iron-acquisition systems.	Iron	158-162	transferrin	Homo sapiens	58-69
18202490-8	2005	We conclude that IV iron saccharate use to replenish and maintain iron stores in stable EPO treated HD patients is safe and effective.	Iron	20-24	erythropoietin	Homo sapiens	88-91
15880095-1	2005	Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophore- and transferrin-binding protein (named IsdA)-mediated iron-acquisition systems.	Iron	158-162	transferrin	Homo sapiens	108-119
15880095-2	2005	This study was designed in order to determine which iron-acquisition system plays the essential or dominant role with respect to the acquisition of iron from human transferrin, in the growth of S. aureus.	Iron	52-56	transferrin	Homo sapiens	164-175
15880095-2	2005	This study was designed in order to determine which iron-acquisition system plays the essential or dominant role with respect to the acquisition of iron from human transferrin, in the growth of S. aureus.	Iron	148-152	transferrin	Homo sapiens	164-175
15880095-4	2005	S. aureus consumed most of the transferrin-bound iron during the exponential growth phase.	Iron	49-53	transferrin	Homo sapiens	31-42
15880095-9	2005	The siderophores proved to have the ability to remove iron directly from transferrin, but the washed whole cells expressing IsdA did not.	Iron	54-58	transferrin	Homo sapiens	73-84
15880095-10	2005	In the bioassay, the growth of S. aureus on transferrin-bound iron was stimulated by the siderophores alone.	Iron	62-66	transferrin	Homo sapiens	44-55
15880095-11	2005	These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.	Iron	56-60	transferrin	Homo sapiens	143-154
15880095-11	2005	These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	143-154
15880095-11	2005	These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	265-276
15880095-11	2005	These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	143-154
15880095-11	2005	These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	265-276
15880095-11	2005	These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	143-154
15880095-11	2005	These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	265-276
15798950-0	2005	Iron loading increases cholesterol accumulation and macrophage scavenger receptor I expression in THP-1 mononuclear phagocytes.	Iron	0-4	GLI family zinc finger 2	Homo sapiens	98-103
15798950-4	2005	In the present study, we determined the effect of iron loading of THP-1 mononuclear phagocytes on LDL metabolism.	Iron	50-54	GLI family zinc finger 2	Homo sapiens	66-71
15798950-5	2005	We demonstrated that iron loading of THP-1 cells stimulated conjugated diene formation in LDL in the culture medium.	Iron	21-25	GLI family zinc finger 2	Homo sapiens	37-42
15798950-6	2005	In addition, iron loading of THP-1 cells significantly increased cholesteryl ester accumulation in cells exposed to native LDL, suggesting that during the incubation of the cells with native LDL, the LDL became oxidized and was taken up by the cells.	Iron	13-17	GLI family zinc finger 2	Homo sapiens	29-34
15798950-7	2005	We further demonstrated that the degradation of 125I-oxidized LDL was significantly increased in iron-loaded THP-1 cells.	Iron	97-101	GLI family zinc finger 2	Homo sapiens	109-114
15798950-8	2005	Lastly, we demonstrated that iron loading of THP-1 cells stimulated scavenger receptor expression in these cells.	Iron	29-33	GLI family zinc finger 2	Homo sapiens	45-50
15853921-3	2005	Real-time quantitative reverse transcriptase polymerase chain reaction analysis of cytokine mRNA levels of peripheral blood mononuclear cells (PBMC) obtained from these children showed an association between interleukin-4 (IL-4) mRNA levels and all the biochemical indices of iron that we measured.	Iron	276-280	interleukin 4	Homo sapiens	208-221
15853921-3	2005	Real-time quantitative reverse transcriptase polymerase chain reaction analysis of cytokine mRNA levels of peripheral blood mononuclear cells (PBMC) obtained from these children showed an association between interleukin-4 (IL-4) mRNA levels and all the biochemical indices of iron that we measured.	Iron	276-280	interleukin 4	Homo sapiens	223-227
15853921-5	2005	This study suggests that IL-4 expression by PBMC may be affected by iron status.	Iron	68-72	interleukin 4	Homo sapiens	25-29
15766257-2	2005	IscU functions as a scaffold for Fe-S cluster assembly and transfer, and is known to be a substrate protein for molecular chaperones.	Iron	33-37	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
15750326-2	2005	Cells take up iron via a transferrin-transferrin receptor-dependent endocytotic process.	Iron	14-18	transferrin	Homo sapiens	25-36
15750326-2	2005	Cells take up iron via a transferrin-transferrin receptor-dependent endocytotic process.	Iron	14-18	transferrin	Homo sapiens	37-48
15750326-5	2005	The known proteins of iron transport and storage, transferrin, transferrin receptor and ferritin, have been recently linked with a number of newly identified proteins that are responsible for inherited diseases of iron metabolisms and play critical roles in the maintenance of iron homeostasis.	Iron	22-26	transferrin	Homo sapiens	50-61
15750326-5	2005	The known proteins of iron transport and storage, transferrin, transferrin receptor and ferritin, have been recently linked with a number of newly identified proteins that are responsible for inherited diseases of iron metabolisms and play critical roles in the maintenance of iron homeostasis.	Iron	214-218	transferrin	Homo sapiens	50-61
15766257-3	2005	Kinetic studies of Fe-S cluster transfer from holo IscU to apo Fd in the presence of chaperone DnaK demonstrate an inhibitory effect on the rate of Fe-S cluster transfer from IscU.	Iron	19-23	iron-sulfur cluster assembly enzyme	Homo sapiens	51-55
15762709-2	2005	Low-temperature UV/vis/NIR and MCD spectra of 1 and 2 reflect electronic structures that are dominated by antibonding interactions of the Fe 3d manifold and the equatorial thiolate S 3p orbitals.	Iron	138-140	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	23-53
15766257-3	2005	Kinetic studies of Fe-S cluster transfer from holo IscU to apo Fd in the presence of chaperone DnaK demonstrate an inhibitory effect on the rate of Fe-S cluster transfer from IscU.	Iron	19-23	iron-sulfur cluster assembly enzyme	Homo sapiens	175-179
15766257-3	2005	Kinetic studies of Fe-S cluster transfer from holo IscU to apo Fd in the presence of chaperone DnaK demonstrate an inhibitory effect on the rate of Fe-S cluster transfer from IscU.	Iron	148-152	iron-sulfur cluster assembly enzyme	Homo sapiens	51-55
15766257-3	2005	Kinetic studies of Fe-S cluster transfer from holo IscU to apo Fd in the presence of chaperone DnaK demonstrate an inhibitory effect on the rate of Fe-S cluster transfer from IscU.	Iron	148-152	iron-sulfur cluster assembly enzyme	Homo sapiens	175-179
15777842-1	2005	Iron regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, is subjected to iron-dependent degradation by the proteasome.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	0-25
15777842-1	2005	Iron regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, is subjected to iron-dependent degradation by the proteasome.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	27-31
15766257-6	2005	Rather, DnaK has a modest influence on the stability of the IscU-bound Fe-S cluster that may reflect a more important role in promoting cluster assembly.	Iron	71-75	iron-sulfur cluster assembly enzyme	Homo sapiens	60-64
15777842-1	2005	Iron regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, is subjected to iron-dependent degradation by the proteasome.	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	0-25
15777842-1	2005	Iron regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, is subjected to iron-dependent degradation by the proteasome.	Iron	102-106	iron responsive element binding protein 2	Homo sapiens	27-31
15755598-7	2005	infection model requires an exogenous iron source (e.g. human transferrin) to obtain a lethal bacteraemic infection and can be used to assess both active and passive immunisation.	Iron	38-42	transferrin	Homo sapiens	62-73
15777842-3	2005	Enzymes of this class, such as prolyl-4-hydroxylases, mediate the oxygen and iron-dependent degradation of the hypoxia inducible factor HIF-1alpha, which requires the E3 ubiquitin ligase activity of pVHL.	Iron	77-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
15777842-7	2005	However, the iron-dependent degradation of endogenous IRP2 is not impaired in VHL-deficient cell lines, suggesting that pVHL is not a necessary component of this pathway.	Iron	13-17	iron responsive element binding protein 2	Homo sapiens	54-58
15649888-0	2005	Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis.	Iron	18-22	Aft2p	Saccharomyces cerevisiae S288C	49-53
15649888-0	2005	Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis.	Iron	119-123	Aft2p	Saccharomyces cerevisiae S288C	49-53
15649888-1	2005	Two transcriptional activators, Aft1 and Aft2, regulate iron homeostasis in Saccharomyces cerevisiae.	Iron	56-60	Aft2p	Saccharomyces cerevisiae S288C	41-45
15649888-3	2005	Iron inhibition of Aft1/Aft2 is abrogated in cells defective for Fe-S cluster biogenesis within the mitochondrial matrix (Chen, O. S., Crisp, R. J., Valachovic, M., Bard, M., Winge, D. R., and Kaplan, J.	Iron	0-4	Aft2p	Saccharomyces cerevisiae S288C	24-28
15649888-7	2005	To determine whether iron sensing by Aft1/Aft2 requires the function of the mitochondrial Fe-S export and cytosolic Fe-S protein assembly systems, we evaluated the expression of the iron regulon in cells depleted of glutathione and in cells depleted of Atm1, Nar1, Cfd1, and Nbp35.	Iron	21-25	Aft2p	Saccharomyces cerevisiae S288C	42-46
15649888-12	2005	Thus, iron sensing by Aft1/Aft2 is not linked to the maturation of cytosolic/nuclear Fe-S proteins, but the mitochondrial inner membrane transporter Atm1 is important to transport the inhibitory signal.	Iron	6-10	Aft2p	Saccharomyces cerevisiae S288C	27-31
15649888-13	2005	Although Aft1 and Aft2 sense a signal emanating from the Fe-S cluster biogenesis pathway, there is no indication that the proteins are inhibited by direct binding of an Fe-S cluster.	Iron	57-61	Aft2p	Saccharomyces cerevisiae S288C	18-22
15712215-6	2005	The addition of ferrous iron to the culture medium inhibited caspase-3 activation and apoptotic nuclear morphologic changes and blocked 6-OHDA-induced cytotoxicity in SH-SY5Y cells and primary cultured mesencephalic dopaminergic neurons.	Iron	16-28	caspase 3	Homo sapiens	61-70
15819249-5	2005	Thus, the anions were ranked SO4(2-) &gt; Cl- &gt; or = ClO4- &gt; NO3- &gt; HCO3 (from most enhanced to most inhibited) in their influence on granular iron reactivity toward 4ClNB.	Iron	152-156	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
15798039-3	2005	The purpose of this study was to examine the association of dietary iron intake and the risk of cancer among adults with increased transferrin saturation.	Iron	68-72	transferrin	Homo sapiens	131-142
15716025-2	2005	Serum transferrin (Tf) contains two iron (Fe)-binding sites and plays a vital role in Fe transport.	Iron	36-40	transferrin	Homo sapiens	6-17
15716025-2	2005	Serum transferrin (Tf) contains two iron (Fe)-binding sites and plays a vital role in Fe transport.	Iron	36-40	transferrin	Homo sapiens	19-21
15716025-2	2005	Serum transferrin (Tf) contains two iron (Fe)-binding sites and plays a vital role in Fe transport.	Iron	42-44	transferrin	Homo sapiens	6-17
15716025-2	2005	Serum transferrin (Tf) contains two iron (Fe)-binding sites and plays a vital role in Fe transport.	Iron	42-44	transferrin	Homo sapiens	19-21
15716025-2	2005	Serum transferrin (Tf) contains two iron (Fe)-binding sites and plays a vital role in Fe transport.	Iron	86-88	transferrin	Homo sapiens	6-17
15716025-2	2005	Serum transferrin (Tf) contains two iron (Fe)-binding sites and plays a vital role in Fe transport.	Iron	86-88	transferrin	Homo sapiens	19-21
15798039-11	2005	CONCLUSIONS: Among persons with increased transferrin saturation, a daily intake of dietary iron more than 18 mg is associated with an increased risk of cancer.	Iron	92-96	transferrin	Homo sapiens	42-53
15640283-1	2005	Heme oxygenase-1 (HO-1), which degrades heme into three products (carbon monoxide, free iron, and biliverdin), plays a protective role in many models of disease via its anti-inflammatory, anti-apoptotic, and anti-proliferative actions.	Iron	88-92	heme oxygenase 1	Mus musculus	0-16
15843899-0	2005	Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation.	Iron	0-4	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
15843899-4	2005	Iron deprivation led to the release of cytochrome c from mitochondria into the cytosol only in sensitive cells but it did not affect the cytosolic localization of Apaf-1 in both sensitive and resistant cells.	Iron	0-4	cytochrome c, somatic	Homo sapiens	39-51
15843899-6	2005	The antiapoptotic Bcl-2 protein was found to be associated with mitochondria in both sensitive and resistant cells and the association did not change under iron deprivation.	Iron	156-160	BCL2 apoptosis regulator	Homo sapiens	18-23
15843899-7	2005	On the other hand, under iron deprivation we detected translocation of the proapoptotic Bax protein from the cytosol to mitochondria in sensitive cells but not in resistant cells.	Iron	25-29	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
15843899-8	2005	Taken together, we suggest that iron deprivation induces apoptosis via mitochondrial changes concerning proapoptotic Bax translocation to mitochondria, collapse of the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and caspase-3.	Iron	32-36	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
15843899-8	2005	Taken together, we suggest that iron deprivation induces apoptosis via mitochondrial changes concerning proapoptotic Bax translocation to mitochondria, collapse of the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and caspase-3.	Iron	32-36	cytochrome c, somatic	Homo sapiens	213-225
15843899-8	2005	Taken together, we suggest that iron deprivation induces apoptosis via mitochondrial changes concerning proapoptotic Bax translocation to mitochondria, collapse of the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and caspase-3.	Iron	32-36	caspase 3	Homo sapiens	277-286
15309428-9	2005	Dietary fiber and vitamin A were positively related to IGF-I (p = 0.004 and 0.03), zinc with IGFB-3 (p = 0.0008), and iron with the IGF-I/IGFBP-3 ratio (p = 0.048), but the differences between the bottom and top quartile were less than 10%.	Iron	118-122	insulin like growth factor 1	Homo sapiens	132-137
15708305-4	2005	This in turn depends on well-oxygenated tissues where the oxidation-reduction potential (Eh) and pH control the binding of iron by unsaturated transferrin and lactoferrin.	Iron	123-127	transferrin	Homo sapiens	143-154
15708305-5	2005	Bacterial virulence is greatly enhanced by freely available iron, such as that in fully-saturated transferrin or free haemoglobin.	Iron	60-64	transferrin	Homo sapiens	98-109
15708305-6	2005	Following trauma a fall in tissue Eh and pH due to ischaemia, plus the reducing powers of bacteria, can make iron in transferrin freely available and abolish the bactericidal properties of tissue fluids with disastrous results for the host.	Iron	109-113	transferrin	Homo sapiens	117-128
15810797-8	2005	The change in transferrin saturation (deltaTS) in the iron-fortified milk group (deltaTS: 3.4+/-12.9%) was greater than that in the placebo and nonfortified milk groups (deltaTS: -10.1+/-9.8% and -11.6+/-10.7 %, respectively) (p &lt; .01).	Iron	54-58	transferrin	Homo sapiens	14-25
15640283-1	2005	Heme oxygenase-1 (HO-1), which degrades heme into three products (carbon monoxide, free iron, and biliverdin), plays a protective role in many models of disease via its anti-inflammatory, anti-apoptotic, and anti-proliferative actions.	Iron	88-92	heme oxygenase 1	Mus musculus	18-22
15713745-5	2005	We examined the effect of PEDF on kinase activity of Fyn and found that PEDF downregulated FGF-2-promoted Fyn activity by tyrosine phosphorylation at the C-terminus in a Fes-dependent manner.	Iron	170-173	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	72-76
15711640-7	2005	The Ngal:siderophore:Fe complex upregulates heme oxygenase-1, a protective enzyme, preserves proximal tubule N-cadherin, and inhibits cell death.	Iron	21-23	heme oxygenase 1	Mus musculus	44-60
15799959-7	2005	Further work established that compound 1 was a potent intracellular iron chelator that inhibited both IL-12/IL-18- and IL-4-mediated T cell proliferation.	Iron	68-72	interleukin 4	Homo sapiens	119-123
15799959-9	2005	Thus, the IL-12/IL-18-mediated proliferation and IFN-gamma secretion are very sensitive to intracellular iron concentration.	Iron	105-109	interferon gamma	Homo sapiens	49-58
15799959-10	2005	However, the IL-4-mediated IL-13 secretion does not correlate with proliferation and is partially resistant to potent iron chelation.	Iron	118-122	interleukin 4	Homo sapiens	13-17
15799959-10	2005	However, the IL-4-mediated IL-13 secretion does not correlate with proliferation and is partially resistant to potent iron chelation.	Iron	118-122	interleukin 13	Homo sapiens	27-32
15494549-4	2005	Cells were exposed to arachidonic acid (AA) plus Fe, which has been previously reported to cause a synergistic toxicity in E47 cells by a mechanism dependent on CYP2E1 activity and involving oxidative stress and lipid peroxidation.	Iron	49-51	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	161-167
15737207-2	2005	In skin, UVA photoimmunoprotection is mediated by the inducible antioxidant stress enzyme, heme oxygenase-1 (HO-1), which degrades heme into carbon monoxide (CO), iron, and biliverdin (reduced to bilirubin), and is important for cell survival under conditions of oxidative stress.	Iron	163-167	heme oxygenase 1	Mus musculus	91-107
15698458-6	2005	Transferrin-chelatable iron was assessed by fluorescent-apotransferrin, and cell toxicity was assayed by neutral red cytotoxicity test.	Iron	23-27	transferrin	Homo sapiens	0-11
16025871-10	2005	After iron supplementation there was a significant increase in s-ferritin levels and a decrease in s-transferrin levels, with an accompanying significant reduction of the symptom scores of vertigo/dizziness, irritability, depressive symptoms, and indisposition.	Iron	6-10	transferrin	Homo sapiens	101-112
15758237-4	2005	When fri mutant cells were transferred to iron-limiting conditions, growth was retarded relative to wild-type cells, indicating that Fri may be required for iron storage.	Iron	42-46	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	Mus musculus	5-8
15758237-4	2005	When fri mutant cells were transferred to iron-limiting conditions, growth was retarded relative to wild-type cells, indicating that Fri may be required for iron storage.	Iron	42-46	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	Mus musculus	133-136
15758237-4	2005	When fri mutant cells were transferred to iron-limiting conditions, growth was retarded relative to wild-type cells, indicating that Fri may be required for iron storage.	Iron	157-161	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	Mus musculus	5-8
15758237-4	2005	When fri mutant cells were transferred to iron-limiting conditions, growth was retarded relative to wild-type cells, indicating that Fri may be required for iron storage.	Iron	157-161	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	Mus musculus	133-136
15758237-9	2005	Thus, the data suggest that Fri contributes to the ability of L. monocytogenes to survive in environments where oxidative stress and low iron availability may impede bacterial proliferation.	Iron	96-100	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	Mus musculus	28-31
15708745-2	2005	Transferrin, widely known as an iron-binding protein, is one such example of a multi-tasking protein.	Iron	32-36	transferrin	Homo sapiens	0-11
15743620-1	2005	Batch experiments and X-ray photoelectron spectroscopic (XPS) analyses were performed to study the reactions between arsenate [As(V)], arsenite [As(III)] and zero-valent iron [Fe(0)].	Iron	170-174	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	127-132
15743620-2	2005	The As(III) removal rate was higher than that for As(V) when iron filings (80-120 mesh) were mixed with arsenic solutions purged with nitrogen gas in the pH range of 4-7.	Iron	61-65	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-55
15743620-4	2005	Soluble As(III) was formed when As(V) reacted with Fe(0) under anoxic conditions.	Iron	51-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-37
15743620-6	2005	The removal of the arsenic species by Fe(0) was attributed to electrochemical reduction of As(III) to sparsely soluble As(0) and adsorption of As(III) and As(V) to iron hydroxides formed on the Fe(0) surface under anoxic conditions.	Iron	38-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	155-160
15743620-6	2005	The removal of the arsenic species by Fe(0) was attributed to electrochemical reduction of As(III) to sparsely soluble As(0) and adsorption of As(III) and As(V) to iron hydroxides formed on the Fe(0) surface under anoxic conditions.	Iron	38-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	155-160
15743620-8	2005	The rapid removal of As(III) and As(V) was caused by adsorption on ferric hydroxides formed readily through oxidation of Fe(0) by dissolved oxygen.	Iron	121-123	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-38
15557328-0	2005	Down-regulation of iron regulatory protein 1 activities and expression in superoxide dismutase 1 knock-out mice is not associated with alterations in iron metabolism.	Iron	19-23	superoxide dismutase 1, soluble	Mus musculus	74-96
15561708-2	2005	ABA3 is a two-domain protein with an NH2-terminal domain sharing significant similarities to NifS proteins that catalyze the decomposition of l-cysteine to l-alanine and elemental sulfur for iron-sulfur cluster synthesis.	Iron	191-195	molybdenum cofactor sulfurase (LOS5) (ABA3)	Arabidopsis thaliana	0-4
15561708-9	2005	However, the sulfur transferase activity of ABA3 is used for post-translational activation of molybdenum enzymes rather than for iron-sulfur cluster assembly.	Iron	129-133	molybdenum cofactor sulfurase (LOS5) (ABA3)	Arabidopsis thaliana	44-48
15659854-1	2005	The [FeLn(NCS)2] iron(II) spin-crossover complexes cover a wide range of magnetic behaviour.	Iron	17-21	cytosolic thiouridylase subunit 2	Homo sapiens	10-15
15686373-1	2005	The mammalian iron transporter, divalent metal transporter (DMT1), is a 12-transmembrane domain integral protein, responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	14-18	transferrin	Homo sapiens	192-203
15686373-1	2005	The mammalian iron transporter, divalent metal transporter (DMT1), is a 12-transmembrane domain integral protein, responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	138-142	transferrin	Homo sapiens	192-203
15621297-3	2005	ESI-MS (Electron-Spray Ionization Mass Spectrometry) investigations carried out both on iron and zinc complexes in solution have evidenced various species with different MHA/metal ratios.	Iron	88-92	myosin heavy chain 9	Homo sapiens	170-173
15699234-2	2005	Whether intestinal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), are present in the mammary gland and are involved in iron transfer into milk are unknown.	Iron	19-23	solute carrier family 40 member 1	Rattus norvegicus	78-91
15699234-2	2005	Whether intestinal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), are present in the mammary gland and are involved in iron transfer into milk are unknown.	Iron	19-23	solute carrier family 40 member 1	Rattus norvegicus	93-97
15699234-11	2005	On day 20, transferrin receptor increased in the low-iron rats, whereas mammary gland iron, ferritin, DMT1, and FPN1 were unchanged.	Iron	53-57	transferrin	Rattus norvegicus	11-22
15699234-12	2005	CONCLUSIONS: The results show that DMT1 and FPN1 concentrations are higher during early lactation and are possibly involved in iron transfer into milk.	Iron	127-131	solute carrier family 40 member 1	Rattus norvegicus	44-48
15699234-13	2005	Mammary gland regulation of DMT and FPN1 during low iron status appears to be different from that in the intestine.	Iron	52-56	solute carrier family 40 member 1	Rattus norvegicus	36-40
15494544-0	2005	Parenteral iron compounds sensitize mice to injury-initiated TNF-alpha mRNA production and TNF-alpha release.	Iron	11-15	tumor necrosis factor	Mus musculus	61-70
15494544-0	2005	Parenteral iron compounds sensitize mice to injury-initiated TNF-alpha mRNA production and TNF-alpha release.	Iron	11-15	tumor necrosis factor	Mus musculus	91-100
15494544-9	2005	Each Fe preparation significantly enhanced LPS- or muscle injury-mediated TNF-alpha generation.	Iron	5-7	toll-like receptor 4	Mus musculus	43-46
15494544-9	2005	Each Fe preparation significantly enhanced LPS- or muscle injury-mediated TNF-alpha generation.	Iron	5-7	tumor necrosis factor	Mus musculus	74-83
15494544-14	2005	We conclude 1) intravenous Fe can enhance TNF-alpha generation during LPS- or glycerol-induced tissue damage; 2) increased TNF-alpha gene transcription in the kidney, heart, and lung may contribute to this result; and 3) intramuscular administration, but not GSH, might potentially mitigate some of Fe"s systemic toxic effects.	Iron	27-29	tumor necrosis factor	Mus musculus	42-51
15494544-14	2005	We conclude 1) intravenous Fe can enhance TNF-alpha generation during LPS- or glycerol-induced tissue damage; 2) increased TNF-alpha gene transcription in the kidney, heart, and lung may contribute to this result; and 3) intramuscular administration, but not GSH, might potentially mitigate some of Fe"s systemic toxic effects.	Iron	27-29	toll-like receptor 4	Mus musculus	70-73
15494544-14	2005	We conclude 1) intravenous Fe can enhance TNF-alpha generation during LPS- or glycerol-induced tissue damage; 2) increased TNF-alpha gene transcription in the kidney, heart, and lung may contribute to this result; and 3) intramuscular administration, but not GSH, might potentially mitigate some of Fe"s systemic toxic effects.	Iron	27-29	tumor necrosis factor	Mus musculus	123-132
15629124-6	2005	The iron ligands of soybean lipoxygenase-1 are two His residues in the sequence HWLNTH, one His residue and a distant Asn residue in the sequence HAAVNFGQ, and the C-terminal Ile residue.	Iron	4-8	seed linoleate 13S-lipoxygenase-1	Glycine max	28-42
15749641-2	2005	Among the 70 target genes of HIF-1 known so far, several are involved in angiogenesis, erythropoiesis, cell proliferation, cell viability, and glucose and iron metabolisms.	Iron	155-159	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-34
15730050-0	2005	Recombinant human erythropoietin independence in chronic hemodialysis patients: clinical features, iron homeostasis and erythropoiesis.	Iron	99-103	erythropoietin	Homo sapiens	18-32
15664936-1	2005	Neisseria meningitidis, a causative agent of bacterial meningitis and septicemia, obtains transferrin-bound iron by expressing two outer membrane-located transferrin-binding proteins, TbpA and TbpB.	Iron	108-112	transferrin	Homo sapiens	90-101
15664936-1	2005	Neisseria meningitidis, a causative agent of bacterial meningitis and septicemia, obtains transferrin-bound iron by expressing two outer membrane-located transferrin-binding proteins, TbpA and TbpB.	Iron	108-112	transferrin	Homo sapiens	154-165
15664936-11	2005	However, iron loss from the diferric human transferrin-TbpA-TbpB complex was not greater than that from human transferrin alone, suggesting that additional meningococcal transport components are involved in the process of iron removal.	Iron	9-13	transferrin	Homo sapiens	43-54
15664936-11	2005	However, iron loss from the diferric human transferrin-TbpA-TbpB complex was not greater than that from human transferrin alone, suggesting that additional meningococcal transport components are involved in the process of iron removal.	Iron	222-226	transferrin	Homo sapiens	43-54
15466921-10	2005	The estradiol and FE effect on renal calcium excretion remained significant after adjusting for calcium filtered at the glomerulus and serum PTH.	Iron	18-20	parathyroid hormone	Homo sapiens	141-144
15621297-6	2005	Experiments in vitro with human intestinal Caco-2 cells indicated that the MHA/Fe chelate was taken up by the cells without any apparent toxic effect.	Iron	79-81	myosin heavy chain 9	Homo sapiens	75-78
15840341-0	2005	[The role of interleukin-2 in iron powder-induced intraocular inflammation].	Iron	30-34	interleukin-2	Oryctolagus cuniculus	13-26
15684386-1	2005	Iron-regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, undergoes proteasomal degradation in iron-replete cells, while it is stabilized in iron deficiency or hypoxia.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	0-25
15684386-1	2005	Iron-regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, undergoes proteasomal degradation in iron-replete cells, while it is stabilized in iron deficiency or hypoxia.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	27-31
15684386-1	2005	Iron-regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, undergoes proteasomal degradation in iron-replete cells, while it is stabilized in iron deficiency or hypoxia.	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	0-25
15684386-1	2005	Iron-regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, undergoes proteasomal degradation in iron-replete cells, while it is stabilized in iron deficiency or hypoxia.	Iron	123-127	iron responsive element binding protein 2	Homo sapiens	27-31
15759960-7	2005	Although peak serum iron level (340 microg/dL) was significantly lower than that reported to cause hepatotoxicity (&gt;1,700 microg/dL), rapid and significant elevations in aminotransferases (&gt;4,000 U/L), total bilirubin (5 mg/dL), and prothrombin time (50 seconds) occurred within 48 hours.	Iron	20-24	coagulation factor II, thrombin	Homo sapiens	239-250
15764147-6	2005	RESULTS: Dcytb (duodenal ferric reductase) was expressed at very low levels in the large intestine, compared to the duodenum, while Ireg1 and DMT1 were expressed at significant levels in the large intestine and were increased in iron-deficient caecum, proximal and distal colon, with the most significant increases seen in the distal colon.	Iron	229-233	cytochrome b reductase 1	Mus musculus	9-14
15764147-11	2005	Colonic epithelial cells express basolateral IREG1in the same fashion as in the duodenum and this protein could regulate colonic epithelial cell iron levels.	Iron	145-149	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	45-50
15665091-0	2005	Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin.	Iron	0-4	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	75-88
15665091-1	2005	Ferroportin 1 (FPN1) is transmembrane protein involved in iron homeostasis.	Iron	58-62	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-13
15665091-1	2005	Ferroportin 1 (FPN1) is transmembrane protein involved in iron homeostasis.	Iron	58-62	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-19
15665091-2	2005	In the duodenum, FPN1 localizes to the basolateral surface of enterocytes where it appears to export iron out of the cell and into the portal circulation.	Iron	101-105	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	17-21
15665091-3	2005	FPN1 is also abundantly expressed in reticuloendothelial macrophages of the liver, spleen, and bone marrow, suggesting that this protein serves as an iron exporter in cells that recycle iron from senescent red blood cells.	Iron	150-154	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-4
15665091-3	2005	FPN1 is also abundantly expressed in reticuloendothelial macrophages of the liver, spleen, and bone marrow, suggesting that this protein serves as an iron exporter in cells that recycle iron from senescent red blood cells.	Iron	186-190	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-4
15665091-4	2005	To directly test the hypothesis that FPN1 functions in the export of iron after erythrophagocytosis, FPN1 was stably expressed in J774 mouse macrophages by using retroviral transduction, and release of 59Fe after phagocytosis of 59Fe-labeled rat erythrocytes was measured.	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	37-41
15665091-5	2005	J774 cells overexpressing FPN1 released 70% more 59Fe after erythrophagocytosis than control cells, consistent with a role in the recycling of iron from senescent red cells.	Iron	143-147	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	26-30
15665091-8	2005	We conclude that FPN1 is directly involved in the export of iron during erythrocyte-iron recycling by macrophages.	Iron	60-64	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	17-21
15665091-8	2005	We conclude that FPN1 is directly involved in the export of iron during erythrocyte-iron recycling by macrophages.	Iron	84-88	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	17-21
15637325-3	2005	This study, therefore, examined whether another iron-containing component of blood, holo-transferrin (holo-Tf), might also induce brain injury either alone or in combination with thrombin, another factor involved in early ICH-induced brain injury.	Iron	48-52	transferrin	Rattus norvegicus	89-100
15637325-8	2005	However, the combination of holo-Tf with thrombin (but not apo-Tf with thrombin) caused brain edema, DNA damage, and intracellular iron accumulation in the ipsilateral basal ganglia.	Iron	131-135	coagulation factor II	Rattus norvegicus	41-49
15840341-1	2005	OBJECTIVE: To investigate the role of interleukin 2 (IL-2) in iron powder-induced intraocular inflammation in rabbits.	Iron	62-66	interleukin-2	Oryctolagus cuniculus	38-51
15840341-1	2005	OBJECTIVE: To investigate the role of interleukin 2 (IL-2) in iron powder-induced intraocular inflammation in rabbits.	Iron	62-66	interleukin-2	Oryctolagus cuniculus	53-57
15550384-0	2005	Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.	Iron	0-4	tumor necrosis factor	Homo sapiens	82-109
15840341-5	2005	RESULTS: The inflammatory reaction of the anterior chamber was diminished and IL-2 concentrations in aqueous humor were significantly (P &lt; 0.01) reduced in iron powder with SIL-2R injection group at 3, 5, 7, and 10 days (41.7 +/- 2.38, 102.3 +/- 2.46, 79.4 +/- 2.49, 31.6 +/- 1.80 pg/ml, Mean +/- SD, n = 8, respectively) when compared with iron powder injection group (158.5 +/- 4.76, 659.6 +/- 1.84, 511.7 +/- 3.35, and 79.4 +/- 2.85 pg/ml, Mean +/- SD, n = 8, respectively).	Iron	159-163	interleukin-2	Oryctolagus cuniculus	78-82
15840341-6	2005	Compared with control group, the levels of IL-2 were significantly (P &lt; 0.05) increased in both iron powder and iron powder plus SIL-2R group.	Iron	99-103	interleukin-2	Oryctolagus cuniculus	43-47
15642597-4	2005	In the present research, we covalently attached artemisinin to the iron-carrying plasma glycoprotein transferrin.	Iron	67-71	transferrin	Homo sapiens	101-112
15642597-6	2005	Thus, we hypothesize that by tagging artemisinin to transferrin, both iron and artemisinin would be transported into cancer cells in one package.	Iron	70-74	transferrin	Homo sapiens	52-63
15840341-6	2005	Compared with control group, the levels of IL-2 were significantly (P &lt; 0.05) increased in both iron powder and iron powder plus SIL-2R group.	Iron	115-119	interleukin-2	Oryctolagus cuniculus	43-47
15642597-7	2005	Once inside a cell, iron is released and can readily react with artemisinin close by tagged to the transferrin.	Iron	20-24	transferrin	Homo sapiens	99-110
15840341-7	2005	CONCLUSIONS: Our results suggest that IL-2 play an important role in iron powder-induced intraocular inflammation that can be diminished by the inhibition of IL-2 receptor.	Iron	69-73	interleukin-2	Oryctolagus cuniculus	38-42
15840341-7	2005	CONCLUSIONS: Our results suggest that IL-2 play an important role in iron powder-induced intraocular inflammation that can be diminished by the inhibition of IL-2 receptor.	Iron	69-73	interleukin-2	Oryctolagus cuniculus	158-162
15659606-0	2005	Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2.	Iron	84-88	pantothenate kinase 2	Homo sapiens	177-198
15659606-1	2005	Mutations in the pantothenate kinase 2 (PANK2) gene have been identified in patients with neurodegeneration with brain iron accumulation (NBIA; formerly Hallervorden-Spatz disease).	Iron	119-123	pantothenate kinase 2	Homo sapiens	17-38
15659606-1	2005	Mutations in the pantothenate kinase 2 (PANK2) gene have been identified in patients with neurodegeneration with brain iron accumulation (NBIA; formerly Hallervorden-Spatz disease).	Iron	119-123	pantothenate kinase 2	Homo sapiens	40-45
15707067-1	2005	This study investigated the reaction mechanisms of nitrate (NO3-) with zerovalent iron (ZVI) media under conditions relevantto groundwatertreatment using permeable reactive barriers (PRB).	Iron	82-86	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
15707067-2	2005	Reaction rates of NO3- with freely corroding and with cathodically or anodically polarized iron wires were measured in batch reactors.	Iron	91-95	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
15707067-4	2005	Reduction of NO3- by corroding iron resulted in near stoichiometric production of NO2-, which did not measurably react in the absence of added Fe(II).	Iron	31-35	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
15707067-7	2005	This behavior can be attributed to formation of a microporous oxide on the iron surfaces that blocked reduction of NO3- and NO2- but did not block water reduction.	Iron	75-79	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
15707067-8	2005	This finding is consistent with previous observations that NO3- impedes reduction of organic compounds by ZVI.	Iron	106-109	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Iron	34-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
15355847-2	2005	The divalent metal transporter DMT1 is a key modulator of transferrin- and non-transferrin-bound iron homeostasis.	Iron	97-101	solute carrier family 11 member 2	Rattus norvegicus	31-35
16003938-3	2005	Iron is rather unavailable because it occurs in its insoluble ferric form in oxides and hydroxides, while in serum of mammalian hosts is highly bound to carrier proteins such as transferrin, so the free iron concentration is extremely low insufficient for microbial growth.	Iron	0-4	transferrin	Homo sapiens	178-189
16003938-3	2005	Iron is rather unavailable because it occurs in its insoluble ferric form in oxides and hydroxides, while in serum of mammalian hosts is highly bound to carrier proteins such as transferrin, so the free iron concentration is extremely low insufficient for microbial growth.	Iron	203-207	transferrin	Homo sapiens	178-189
15355847-10	2005	Our data suggest an important role for DMT1 in intracellular iron handling during spermatogenesis and imply that germ cells have a need for a precisely targeted and timed supply of iron.	Iron	61-65	solute carrier family 11 member 2	Rattus norvegicus	39-43
15355847-11	2005	We suggest that DMT1 may, as it does in other tissues, play a role in transporting iron between intracellular compartments and thus may play an important role in male fertility.	Iron	83-87	solute carrier family 11 member 2	Rattus norvegicus	16-20
16403985-6	2005	Since little is known about the non-transferrin-mediated iron metabolism of the brain during anoxia/reoxygenation, we tested the ability of the microglial cell line RAW 264.7 to take up iron independently of transferrin under various oxygen concentrations.	Iron	57-61	transferrin	Homo sapiens	36-47
16339692-0	2005	Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major.	Iron	22-26	transferrin	Homo sapiens	4-15
16339692-1	2005	Serum non-transferrin-bound iron (NTBI) levels assessed at arbitrary time points during transfusion cycles may not be representative if NTBI is undergoing significant changes during transfusion cycles.	Iron	28-32	transferrin	Homo sapiens	10-21
16305465-7	2005	Our current knowledge and understanding of the structure of members of the transferrin family of iron-binding proteins and the nature of the iron-binding centres in transferrins is presented, together with information on the processes of iron-uptake and iron-release by transferrin and a summary of the elements that have been found to bind to transferrins.	Iron	97-101	transferrin	Homo sapiens	75-86
16403978-1	2005	Iron regulatory proteins (IRP1 and 2) function as translational regulators that coordinate the cellular iron metabolism of eukaryotes by binding to the mRNA of target genes such as the transferrin receptor or ferritin.	Iron	0-4	transferrin	Homo sapiens	185-196
16403978-1	2005	Iron regulatory proteins (IRP1 and 2) function as translational regulators that coordinate the cellular iron metabolism of eukaryotes by binding to the mRNA of target genes such as the transferrin receptor or ferritin.	Iron	104-108	transferrin	Homo sapiens	185-196
16305465-3	2005	We review our current understanding of the intestinal absorption of iron in the light of recently identified membrane proteins, namely the ferrric reductase, Dcytb, the two iron(II) transport proteins, DMT1 and ferroportin/Ireg1, and hephaestin, the membrane-bound homologue of the ferroxidase ceruloplasmin.	Iron	68-72	charged multivesicular body protein 2B	Homo sapiens	202-206
16305465-7	2005	Our current knowledge and understanding of the structure of members of the transferrin family of iron-binding proteins and the nature of the iron-binding centres in transferrins is presented, together with information on the processes of iron-uptake and iron-release by transferrin and a summary of the elements that have been found to bind to transferrins.	Iron	141-145	transferrin	Homo sapiens	165-176
16305465-7	2005	Our current knowledge and understanding of the structure of members of the transferrin family of iron-binding proteins and the nature of the iron-binding centres in transferrins is presented, together with information on the processes of iron-uptake and iron-release by transferrin and a summary of the elements that have been found to bind to transferrins.	Iron	141-145	transferrin	Homo sapiens	165-176
16305465-7	2005	Our current knowledge and understanding of the structure of members of the transferrin family of iron-binding proteins and the nature of the iron-binding centres in transferrins is presented, together with information on the processes of iron-uptake and iron-release by transferrin and a summary of the elements that have been found to bind to transferrins.	Iron	141-145	transferrin	Homo sapiens	165-176
15589375-1	2005	Heme oxygenases (HO-1 and HO-2) catalyze the NADPH-cytochrome P(450) reductase (CPR)-dependent degradation of heme into iron, carbon monoxide, and biliverdin, which is reduced into bilirubin.	Iron	120-124	cytochrome p450 oxidoreductase	Homo sapiens	45-78
15280908-9	2005	Furthermore, iron deficiency was significantly more prevalent among boys of lower SES, who were also found to have significantly lower levels of serum iron, serum ferritin, transferrin saturation, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration compared to those of higher SES.	Iron	13-17	transferrin	Homo sapiens	173-184
15589375-1	2005	Heme oxygenases (HO-1 and HO-2) catalyze the NADPH-cytochrome P(450) reductase (CPR)-dependent degradation of heme into iron, carbon monoxide, and biliverdin, which is reduced into bilirubin.	Iron	120-124	cytochrome p450 oxidoreductase	Homo sapiens	80-83
15574383-5	2005	Besides divalent metal transporters of the Nramp type and ferrous iron transport proteins of the Feo type, four distinct families of ABC transporters related to iron uptake are known.	Iron	161-165	solute carrier family 11 member 1	Homo sapiens	43-48
16187331-6	2005	Iron deficient slices retained a developmentally immature P15 pattern of LTP expression at P30 and after iron repletion, and LTP expression was lower (P &lt; 0.05) in the iron deficient group at P65.	Iron	171-175	synaptotagmin 1	Rattus norvegicus	195-198
16207112-7	2005	The comparison of outcomes before (28 months period with EPO+Fe treatment to all premature &lt;or=32 weeks gestational age) and after 20 months of implementation of the new protocol showed a significant decrease in EPO+Fe treatment candidates (40.3% vs. 85.9%, P&lt;0.001) without changes in the percentage of transfusions in both periods.	Iron	61-63	erythropoietin	Homo sapiens	215-218
15642666-0	2005	The soluble transferrin receptor as a marker of iron homeostasis in normal subjects and in HFE-related hemochromatosis.	Iron	48-52	transferrin	Homo sapiens	12-23
16207112-7	2005	The comparison of outcomes before (28 months period with EPO+Fe treatment to all premature &lt;or=32 weeks gestational age) and after 20 months of implementation of the new protocol showed a significant decrease in EPO+Fe treatment candidates (40.3% vs. 85.9%, P&lt;0.001) without changes in the percentage of transfusions in both periods.	Iron	219-221	erythropoietin	Homo sapiens	57-60
15790548-8	2005	The plot indicates the correlation between a marker of the iron supply for erythropoiesis (ie, the ratio of the soluble transferrin receptor value to the logarithm of the ferritin value) and the reticulocyte hemoglobin content and functions as a marker of iron demand.	Iron	59-63	transferrin	Homo sapiens	120-131
15790548-8	2005	The plot indicates the correlation between a marker of the iron supply for erythropoiesis (ie, the ratio of the soluble transferrin receptor value to the logarithm of the ferritin value) and the reticulocyte hemoglobin content and functions as a marker of iron demand.	Iron	256-260	transferrin	Homo sapiens	120-131
16473635-2	2005	In the case of the transferrin receptor, receptor recycling is an important step for facilitating iron uptake into the cell, by regulating the availability of the receptor at the cell surface.	Iron	98-102	transferrin	Homo sapiens	19-30
15614199-4	2005	MATERIAL/METHODS: In this study we investigated whether raloxifene is able to inhibit in vitro iron-mediated oxidation of fibrinogen.	Iron	95-99	fibrinogen beta chain	Homo sapiens	122-132
18257208-13	2005	Ferremia and blood count improved in patients who did not receive erythropoietin during the follow-up, and patients on erythropoietin therapy required lower doses after receiving the intraveonous iron therapy.	Iron	196-200	erythropoietin	Homo sapiens	119-133
15640610-0	2005	Effects of intravenous polymaltose iron on oxidant stress and non-transferrin-bound iron in hemodialysis patients.	Iron	84-88	transferrin	Homo sapiens	66-77
16275334-3	2005	Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, HOIL-1, as an ubiquitin ligase recognizing IRP2 through a signal created by heme-mediated oxidative modification of the protein.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	55-80
16275334-3	2005	Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, HOIL-1, as an ubiquitin ligase recognizing IRP2 through a signal created by heme-mediated oxidative modification of the protein.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	82-86
16275334-3	2005	Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, HOIL-1, as an ubiquitin ligase recognizing IRP2 through a signal created by heme-mediated oxidative modification of the protein.	Iron	26-30	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	190-196
16275334-3	2005	Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, HOIL-1, as an ubiquitin ligase recognizing IRP2 through a signal created by heme-mediated oxidative modification of the protein.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	233-237
16275334-3	2005	Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, HOIL-1, as an ubiquitin ligase recognizing IRP2 through a signal created by heme-mediated oxidative modification of the protein.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	82-86
16275334-3	2005	Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, HOIL-1, as an ubiquitin ligase recognizing IRP2 through a signal created by heme-mediated oxidative modification of the protein.	Iron	55-59	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	190-196
16275334-3	2005	Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, HOIL-1, as an ubiquitin ligase recognizing IRP2 through a signal created by heme-mediated oxidative modification of the protein.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	233-237
15750726-2	2005	One of those loci, FRR1 , was previously found homologous to MRS3 and MRS4 of Saccharomyces cerevisiae , which determine proteins involved in mitochondrial transport of iron.	Iron	169-173	Fe(2+) transporter	Saccharomyces cerevisiae S288C	61-65
15640610-7	2005	In study B, the serum iron and transferrin saturation index increased during iron infusion and NTBI transiently appeared in some patients but markers of oxidative stress were not significantly affected.	Iron	77-81	transferrin	Homo sapiens	31-42
16244505-9	2005	In addition, studies suggest that intravenous iron supplementation can improve response to epoetin therapy in patients with functional iron deficiency.	Iron	46-50	erythropoietin	Homo sapiens	91-98
15787086-5	2005	The two primary tests used to assess iron status are transferrin saturation and serum ferritin level.	Iron	37-41	transferrin	Homo sapiens	53-64
15731565-0	2005	Suppressive effects of iron on TGF-beta1 production by renal proximal tubular epithelial cells.	Iron	23-27	transforming growth factor beta 1	Homo sapiens	31-40
15731565-3	2005	The aim of the present study was to examine the direct effects of iron on TGF-beta1 production and the expression of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a marker of oxidative stress, by human renal proximal tubular epithelial cells (RPTEC).	Iron	66-70	transforming growth factor beta 1	Homo sapiens	74-83
15731565-7	2005	Desferrioxamine, an iron chelator, eliminated the suppressive effect of ferric citrate on TGF-beta1 production.	Iron	20-24	transforming growth factor beta 1	Homo sapiens	90-99
15731565-8	2005	CONCLUSIONS: The results suggest that iron may delay the repair of kidney injury during the acute inflammatory phase via a reduction in TGF-beta1 production by RPTEC.	Iron	38-42	transforming growth factor beta 1	Homo sapiens	136-145
19284357-4	2005	Bacteria employ both membrane-bound transferrin receptors and high-affinity iron-binding proteins called siderophores to acquire Fe.	Iron	129-131	transferrin	Homo sapiens	36-47
15709482-2	2005	Abeta and its precursor protein (APP) interact with metal ions such as zinc, copper and iron.	Iron	88-92	amyloid beta precursor protein	Homo sapiens	0-5
16136520-4	2005	It is demonstrated that both synthetic phosphopeptides and phosphopeptides from bovine beta-casein and alpha-casein form phosphopeptide-metal ion complexes containing iron and aluminum ions, resulting in a dramatic decrease in signal intensity of the protonated phosphopeptides.	Iron	167-171	casein beta	Bos taurus	87-98
19284357-5	2005	Humans utilize the iron-binding proteins lactoferrin, transferrin, and ferritin to move Fe away from sites of infection and into storage.	Iron	19-23	transferrin	Homo sapiens	54-65
19284357-5	2005	Humans utilize the iron-binding proteins lactoferrin, transferrin, and ferritin to move Fe away from sites of infection and into storage.	Iron	88-90	transferrin	Homo sapiens	54-65
19284357-7	2005	RESULTS: Iron overload leads to inhibition of IFN-gamma, TNF-alpha, IL-12, and nitric oxide formation as well as impairment of macrophage, neutrophil, and T-cell function.	Iron	9-13	interferon gamma	Homo sapiens	46-55
19284357-7	2005	RESULTS: Iron overload leads to inhibition of IFN-gamma, TNF-alpha, IL-12, and nitric oxide formation as well as impairment of macrophage, neutrophil, and T-cell function.	Iron	9-13	tumor necrosis factor	Homo sapiens	57-66
15456753-3	2004	Grx5 locates at the mitochondrial matrix and is needed for iron/sulfur cluster biogenesis.	Iron	59-63	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	0-4
15531878-2	2004	This is achieved through a variety of iron-binding proteins including transferrin and ferritin.	Iron	38-42	transferrin	Homo sapiens	70-81
15319290-1	2004	Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf).	Iron	100-104	transferrin	Homo sapiens	111-122
15319290-1	2004	Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf).	Iron	100-104	transferrin	Homo sapiens	24-26
15319290-11	2004	Our results support a role for TfR2 in monitoring iron levels by sensing changes in the concentration of diferric Tf.	Iron	50-54	transferrin	Homo sapiens	31-33
15669313-11	2004	Below As(V) surface saturation on goethite, As(V) formed bidentate binuclear bridging complexes on Fe and/or Zn octahedra, while Zn mainly formed edge-sharing complexes with Fe at the goethite surface.	Iron	99-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	44-49
15669323-7	2004	At short contact times, TR6 and Fe-TR formed weak physical bonds with FA, as the respective spin-lattice relaxation times (T1) decreased from the range 1300-1831 ms for TR6 or Fe-TR analyzed in the absence of FA to the range 150-410 ms for TR6/FA or Fe-TR/FA mixtures.	Iron	32-34	TNF receptor superfamily member 6b	Homo sapiens	169-172
15647011-4	2005	RESULTS: Assuming that the most precise measure for body iron storage is related to the logarithm of the ratio of soluble transferrin receptor to ferritin, the sensitivity of ferritin for the diagnosis of iron depletion was 89 percent compared to 57 percent for HYPOm and CHr, respectively, to 69 percent for the combination of both RBC indexes, and to 26 percent for Hb concentration.	Iron	57-61	transferrin	Homo sapiens	122-133
15647011-4	2005	RESULTS: Assuming that the most precise measure for body iron storage is related to the logarithm of the ratio of soluble transferrin receptor to ferritin, the sensitivity of ferritin for the diagnosis of iron depletion was 89 percent compared to 57 percent for HYPOm and CHr, respectively, to 69 percent for the combination of both RBC indexes, and to 26 percent for Hb concentration.	Iron	205-209	transferrin	Homo sapiens	122-133
15604406-3	2004	We found that IRP2-/- cells misregulated iron metabolism when cultured in 3 to 6% oxygen, which is comparable to physiological tissue concentrations, but not in 21% oxygen, a concentration that activated IRP1 and allowed it to substitute for IRP2.	Iron	41-45	iron responsive element binding protein 2	Homo sapiens	14-18
15604406-4	2004	Thus, IRP2 dominates regulation of mammalian iron homeostasis because it alone registers iron concentrations and modulates its RNA-binding activity at physiological oxygen tensions.	Iron	45-49	iron responsive element binding protein 2	Homo sapiens	6-10
15604406-4	2004	Thus, IRP2 dominates regulation of mammalian iron homeostasis because it alone registers iron concentrations and modulates its RNA-binding activity at physiological oxygen tensions.	Iron	89-93	iron responsive element binding protein 2	Homo sapiens	6-10
15669323-7	2004	At short contact times, TR6 and Fe-TR formed weak physical bonds with FA, as the respective spin-lattice relaxation times (T1) decreased from the range 1300-1831 ms for TR6 or Fe-TR analyzed in the absence of FA to the range 150-410 ms for TR6/FA or Fe-TR/FA mixtures.	Iron	32-34	TNF receptor superfamily member 6b	Homo sapiens	169-172
15669323-7	2004	At short contact times, TR6 and Fe-TR formed weak physical bonds with FA, as the respective spin-lattice relaxation times (T1) decreased from the range 1300-1831 ms for TR6 or Fe-TR analyzed in the absence of FA to the range 150-410 ms for TR6/FA or Fe-TR/FA mixtures.	Iron	176-178	TNF receptor superfamily member 6b	Homo sapiens	24-27
15669323-7	2004	At short contact times, TR6 and Fe-TR formed weak physical bonds with FA, as the respective spin-lattice relaxation times (T1) decreased from the range 1300-1831 ms for TR6 or Fe-TR analyzed in the absence of FA to the range 150-410 ms for TR6/FA or Fe-TR/FA mixtures.	Iron	176-178	TNF receptor superfamily member 6b	Homo sapiens	24-27
15669350-0	2004	Decomposition of the polycyclic nitramine explosive, CL-20, by Fe(0).	Iron	63-68	epithelial membrane protein 1	Homo sapiens	53-58
15669350-2	2004	In the present study, zerovalent iron was used to degrade CL-20 with the aim of determining its products and degradation pathways.	Iron	33-37	epithelial membrane protein 1	Homo sapiens	58-63
15317665-8	2004	Tf delivered by TfR2 does not appear to be degraded, which suggests that its delivery to this organelle may be functionally relevant to the storage of iron in overloaded states.	Iron	151-155	transferrin	Homo sapiens	0-2
15507399-3	2004	Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1beta, but caused an increase in IL-6, IL-10, and TNF-alpha production.	Iron	12-16	interleukin 6	Homo sapiens	116-120
15486315-3	2004	METHODS AND RESULTS: Addition of 10 mumol/L non-transferrin-bound iron to the incubation medium caused a 2-fold increase in monocyte adhesion to human umbilical vein endothelial cells (HUVECs).	Iron	66-70	transferrin	Homo sapiens	48-59
15486315-9	2004	CONCLUSIONS: Non-transferrin-bound iron increases the level of intracellular labile iron, which promotes monocyte recruitment to endothelium and may thereby contribute to the pathogenesis of atherosclerosis.	Iron	35-39	transferrin	Homo sapiens	17-28
15486315-9	2004	CONCLUSIONS: Non-transferrin-bound iron increases the level of intracellular labile iron, which promotes monocyte recruitment to endothelium and may thereby contribute to the pathogenesis of atherosclerosis.	Iron	84-88	transferrin	Homo sapiens	17-28
15611622-6	2004	Suppression of ROS by NF-kappaB is mediated by Ferritin heavy chain (FHC)--the primary iron-storage mechanism in cells--and possibly, by the mitochondrial enzyme Mn++ superoxide dismutase (Mn-SOD).	Iron	87-91	nuclear factor kappa B subunit 1	Homo sapiens	22-31
15588700-0	2004	The heme iron coordination of unfolded ferric and ferrous cytochrome c in neutral and acidic urea solutions.	Iron	9-13	cytochrome c, somatic	Homo sapiens	58-70
15588700-2	2004	The heme iron coordination of unfolded ferric and ferrous cytochrome c in the presence of 7-9 M urea at different pH values has been probed by several spectroscopic techniques including magnetic and natural circular dichroism (CD), electrochemistry, UV-visible (UV-vis) absorption and resonance Raman (RR).	Iron	9-13	cytochrome c, somatic	Homo sapiens	58-70
15689106-1	2004	Lactoperoxidase is an iron containing enzyme, which is an essential component of the defense system of mammalian secretary fluids.	Iron	22-26	lactoperoxidase	Homo sapiens	0-15
20368827-11	2004	The target genes of HIF-1 are especially related to angiogenesis, cell proliferation and survival, and to glucose and iron metabolism.	Iron	118-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
15507399-3	2004	Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1beta, but caused an increase in IL-6, IL-10, and TNF-alpha production.	Iron	12-16	tumor necrosis factor	Homo sapiens	133-142
15528049-10	2004	The process was observed in the presence of redox-active chelated iron(II) and of transferrin or ferritin, i.e., two physiological iron sources.	Iron	131-135	transferrin	Homo sapiens	82-93
15668082-3	2004	Serum iron is low with a high concentration of ferritin and low-to-normal transferrin and serum transferrin receptor levels.	Iron	6-10	transferrin	Homo sapiens	74-85
15668082-3	2004	Serum iron is low with a high concentration of ferritin and low-to-normal transferrin and serum transferrin receptor levels.	Iron	6-10	transferrin	Homo sapiens	96-107
15755200-9	2004	Therefore, the NRAMP1 gene promoter polymorphism exhibited an interaction with the lepromin response, suggesting that allele 2 of the NRAMP1 promoter is an independent genetic factor that predisposes cells to enable pathogen survival, probably due to its low efficiency in iron transport.	Iron	273-277	solute carrier family 11 member 1	Homo sapiens	15-21
15755200-9	2004	Therefore, the NRAMP1 gene promoter polymorphism exhibited an interaction with the lepromin response, suggesting that allele 2 of the NRAMP1 promoter is an independent genetic factor that predisposes cells to enable pathogen survival, probably due to its low efficiency in iron transport.	Iron	273-277	solute carrier family 11 member 1	Homo sapiens	134-140
15517438-0	2004	Large cooperativity in the removal of iron from transferrin at physiological temperature and chloride ion concentration.	Iron	38-42	transferrin	Homo sapiens	48-59
15517438-1	2004	Iron removal from serum transferrin by various chelators has been studied by gel electrophoresis, which allows direct quantitation of all four forms of transferrin (diferric, C-monoferric, N-monoferric, and apotransferrin).	Iron	0-4	transferrin	Homo sapiens	24-35
15517438-1	2004	Iron removal from serum transferrin by various chelators has been studied by gel electrophoresis, which allows direct quantitation of all four forms of transferrin (diferric, C-monoferric, N-monoferric, and apotransferrin).	Iron	0-4	transferrin	Homo sapiens	152-163
15517438-2	2004	Large cooperativity between the two lobes of serum transferrin is found for iron removal by several different chelators near physiological conditions (pH 7.4, 37 degrees C, 150 mM NaCl, 20 mM NaHCO(3)).	Iron	76-80	transferrin	Homo sapiens	51-62
15517438-3	2004	This cooperativity is manifested in a dramatic decrease in the rate of iron removal from the N-monoferric transferrin as compared with iron removal from the other forms of ferric transferrin.	Iron	71-75	transferrin	Homo sapiens	106-117
15517438-3	2004	This cooperativity is manifested in a dramatic decrease in the rate of iron removal from the N-monoferric transferrin as compared with iron removal from the other forms of ferric transferrin.	Iron	71-75	transferrin	Homo sapiens	179-190
15517438-3	2004	This cooperativity is manifested in a dramatic decrease in the rate of iron removal from the N-monoferric transferrin as compared with iron removal from the other forms of ferric transferrin.	Iron	135-139	transferrin	Homo sapiens	106-117
15517438-3	2004	This cooperativity is manifested in a dramatic decrease in the rate of iron removal from the N-monoferric transferrin as compared with iron removal from the other forms of ferric transferrin.	Iron	135-139	transferrin	Homo sapiens	179-190
15567100-7	2004	Interleukin-2 (IL-2) production of infected cells was completely inhibited by DFO and excess iron while stress protein (Hsp70) levels were lowered in the presence of HIV in combination with excess iron (37%, P&lt;0.01) or DFO (47.2%, P&lt;0.01) when compared to untreated cells.	Iron	93-97	interleukin 2	Homo sapiens	0-13
15567100-7	2004	Interleukin-2 (IL-2) production of infected cells was completely inhibited by DFO and excess iron while stress protein (Hsp70) levels were lowered in the presence of HIV in combination with excess iron (37%, P&lt;0.01) or DFO (47.2%, P&lt;0.01) when compared to untreated cells.	Iron	93-97	interleukin 2	Homo sapiens	15-19
15567100-4	2004	RESULTS AND CONCLUSION: Excess iron decreased viability (21%, P&lt;0.01) of HIV-infected cells, increased p24 levels by 8.6% (P=0.32) and elevated reverse transcriptase (RT) activity (81.7%, P&lt;0.01).	Iron	31-35	transmembrane p24 trafficking protein 2	Homo sapiens	106-109
15567100-7	2004	Interleukin-2 (IL-2) production of infected cells was completely inhibited by DFO and excess iron while stress protein (Hsp70) levels were lowered in the presence of HIV in combination with excess iron (37%, P&lt;0.01) or DFO (47.2%, P&lt;0.01) when compared to untreated cells.	Iron	197-201	interleukin 2	Homo sapiens	0-13
16462706-0	2004	Reduced insulin growth factor I concentrations in iron-overloaded beta thalassaemic patients with normal growth hormone secretion and liver function.	Iron	50-54	insulin like growth factor 1	Homo sapiens	8-31
15660859-0	2004	Oral iron supplementation in preterm infants treated with erythropoietin.	Iron	5-9	erythropoietin	Homo sapiens	58-72
26443362-6	2004	Expression of the virulence genes occurs in response to an array of environmental signals, including temperature, osmolarity, and pH.At the top of the regulatory hierarchy and lying on the plasmid outside the Entry Region isvirF, encoding an AraC-like transcription factor.Virulence gene expression is also controlled by chromosomal genes,such as those encoding the nucleoid-associated proteins H-NS, IHF, and Fis, the two-component regulators OmpR/EnvZ and CpxR/CpxA, the anaerobic regulator Fnr, the iron-responsive regulator Fur, and the topoisomerases of the cell that modulate DNA supercoiling.	Iron	71-75	long intergenic non-protein coding RNA 1554	Homo sapiens	410-413
15455214-4	2004	Up-regulated genes, clustered mainly in biological processes involving cell adhesion/cytoskeleton, extracellular matrix components, cell cycle, protein modification/phosphorylation, protein metabolism, transcription and inflammation/stress (e.g. key iron and oxygen sensor EGLN1).	Iron	250-254	egl-9 family hypoxia inducible factor 1	Homo sapiens	273-278
15620252-9	2004	Both the induction of HIF-1alpha protein and activation of HIF-1 by 1 can be blocked by iron and ascorbate, indicating that 1 may activate HIF-1 through the chelation of iron.	Iron	88-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-32
15620252-9	2004	Both the induction of HIF-1alpha protein and activation of HIF-1 by 1 can be blocked by iron and ascorbate, indicating that 1 may activate HIF-1 through the chelation of iron.	Iron	88-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-27
15620252-9	2004	Both the induction of HIF-1alpha protein and activation of HIF-1 by 1 can be blocked by iron and ascorbate, indicating that 1 may activate HIF-1 through the chelation of iron.	Iron	88-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-64
15620252-9	2004	Both the induction of HIF-1alpha protein and activation of HIF-1 by 1 can be blocked by iron and ascorbate, indicating that 1 may activate HIF-1 through the chelation of iron.	Iron	170-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-32
15620252-9	2004	Both the induction of HIF-1alpha protein and activation of HIF-1 by 1 can be blocked by iron and ascorbate, indicating that 1 may activate HIF-1 through the chelation of iron.	Iron	170-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-27
15620252-9	2004	Both the induction of HIF-1alpha protein and activation of HIF-1 by 1 can be blocked by iron and ascorbate, indicating that 1 may activate HIF-1 through the chelation of iron.	Iron	170-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-64
15576352-1	2004	The Escherichia coli AlkB protein repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions in DNA and RNA by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively.	Iron	167-179	C-C motif chemokine ligand 28	Homo sapiens	90-93
15539473-3	2004	We report the identification of the essential gene Fe-deficiency Induced Transcription Factor 1 (FIT1), which encodes a putative transcription factor that regulates iron uptake responses in Arabidopsis thaliana.	Iron	165-169	FER-like regulator of iron uptake	Arabidopsis thaliana	51-95
15539473-3	2004	We report the identification of the essential gene Fe-deficiency Induced Transcription Factor 1 (FIT1), which encodes a putative transcription factor that regulates iron uptake responses in Arabidopsis thaliana.	Iron	165-169	FER-like regulator of iron uptake	Arabidopsis thaliana	97-101
15539473-5	2004	fit1 mutant plants are chlorotic and die as seedlings but can be rescued by the addition of supplemental iron, pointing to a defect in iron uptake.	Iron	105-109	FER-like regulator of iron uptake	Arabidopsis thaliana	0-4
15539473-5	2004	fit1 mutant plants are chlorotic and die as seedlings but can be rescued by the addition of supplemental iron, pointing to a defect in iron uptake.	Iron	135-139	FER-like regulator of iron uptake	Arabidopsis thaliana	0-4
15539473-6	2004	fit1 mutant plants accumulate less iron than wild-type plants in root and shoot tissues.	Iron	35-39	FER-like regulator of iron uptake	Arabidopsis thaliana	0-4
15539473-7	2004	Microarray analysis shows that expression of many (72 of 179) iron-regulated genes is dependent on FIT1.	Iron	62-66	FER-like regulator of iron uptake	Arabidopsis thaliana	99-103
15539473-9	2004	We propose a new model for iron uptake in Arabidopsis where FRO2 and IRT1 are differentially regulated by FIT1.	Iron	27-31	FER-like regulator of iron uptake	Arabidopsis thaliana	106-110
15548115-9	2004	Our data strongly suggest that down-regulation of Betaig-h3 expression results from the defect in the TGFB1 signaling pathway and plays a pivotal role in the tumorigenic process induced by (56)Fe heavy-ion radiation.	Iron	193-195	transforming growth factor beta 1	Homo sapiens	102-107
15804800-5	2004	Simultaneous elevation of hs-CRP and leucocyte count increased the risk substantially in those with low iron, OR 9.8 (95% CI 3.9-24.4).	Iron	104-108	C-reactive protein	Homo sapiens	29-32
15916113-0	2004	Comparison of colorimetry and electrothermal atomic absorption spectroscopy for the quantification of non-transferrin bound iron in human sera.	Iron	124-128	transferrin	Homo sapiens	106-117
15544343-9	2004	The relevance of bismuth incorporation by the transferrin receptor-mediated iron acquisition pathway is discussed.	Iron	76-80	transferrin	Homo sapiens	46-57
15382238-3	2004	Grx5 is a Saccharomyces cerevisiae glutaredoxin involved in iron-sulfur cluster (FeSC) biogenesis.	Iron	60-64	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	0-4
15544339-8	2004	Regulation of CBS activity by the iron redox state has been proposed as the role of the heme moiety in this enzyme.	Iron	34-38	cystathionine beta-synthase	Homo sapiens	14-17
15550752-11	2004	Fe administration raised Hb, serum Fe and transferrin saturation in both CRF and CTL groups.	Iron	0-2	transferrin	Rattus norvegicus	42-53
15556641-0	2004	FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana.	Iron	43-47	FER-like regulator of iron uptake	Arabidopsis thaliana	0-3
15556641-0	2004	FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana.	Iron	43-47	FER-like regulator of iron uptake	Arabidopsis thaliana	5-12
15556641-3	2004	Using molecular-genetic techniques, we analyzed the function of BHLH029, named FRU (FER-like regulator of iron uptake), the Arabidopsis thaliana homolog of the tomato FER gene.	Iron	106-110	FER-like regulator of iron uptake	Arabidopsis thaliana	64-71
15556641-3	2004	Using molecular-genetic techniques, we analyzed the function of BHLH029, named FRU (FER-like regulator of iron uptake), the Arabidopsis thaliana homolog of the tomato FER gene.	Iron	106-110	FER-like regulator of iron uptake	Arabidopsis thaliana	79-82
15556641-5	2004	FRU mutant plants were chlorotic, and the FRU gene was found necessary for induction of the essential iron mobilization genes FRO2 (ferric chelate reductase gene) and IRT1 (iron-regulated transporter gene).	Iron	102-106	FER-like regulator of iron uptake	Arabidopsis thaliana	0-3
15556641-5	2004	FRU mutant plants were chlorotic, and the FRU gene was found necessary for induction of the essential iron mobilization genes FRO2 (ferric chelate reductase gene) and IRT1 (iron-regulated transporter gene).	Iron	102-106	FER-like regulator of iron uptake	Arabidopsis thaliana	42-45
15556641-6	2004	Overexpression of FRU resulted in an increase of iron mobilization responses at low iron supply.	Iron	49-53	FER-like regulator of iron uptake	Arabidopsis thaliana	18-21
15556641-6	2004	Overexpression of FRU resulted in an increase of iron mobilization responses at low iron supply.	Iron	84-88	FER-like regulator of iron uptake	Arabidopsis thaliana	18-21
15556641-7	2004	Thus, the FRU gene is a mediator in induction of iron mobilization responses in Arabidopsis, indicating that regulation of iron uptake is conserved in dicot species.	Iron	49-53	FER-like regulator of iron uptake	Arabidopsis thaliana	10-13
15556641-7	2004	Thus, the FRU gene is a mediator in induction of iron mobilization responses in Arabidopsis, indicating that regulation of iron uptake is conserved in dicot species.	Iron	123-127	FER-like regulator of iron uptake	Arabidopsis thaliana	10-13
15537542-6	2004	FHC-mediated inhibition of JNK signaling depends on suppressing ROS accumulation and is achieved through iron sequestration.	Iron	105-109	mitogen-activated protein kinase 8	Homo sapiens	27-30
15506748-2	2004	In resting cyt c, two endogenous ligands of the heme iron are histidine-18 (His) and methionine-80 (Met) side chains, and NO binding requires the cleavage of one of the axial bonds.	Iron	53-57	cytochrome c, somatic	Homo sapiens	11-16
15347649-8	2004	Among the changes that were not explicitly linked to envelope integrity, we characterized a role for the Tat system in iron acquisition and copper homeostasis.	Iron	119-123	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	105-108
15557676-6	2004	Copper and iron had no direct effect on glutathione peroxidase, but they both seem to activate production of HOCl by myeloperoxidase.	Iron	11-15	myeloperoxidase	Homo sapiens	117-132
15521925-1	2004	Transferrin receptor 2 alpha (TfR2 alpha), the major product of the TfR2 gene, is the second receptor for transferrin (Tf), which can mediate cellular iron uptake in vitro.	Iron	151-155	transferrin	Homo sapiens	106-117
15521925-1	2004	Transferrin receptor 2 alpha (TfR2 alpha), the major product of the TfR2 gene, is the second receptor for transferrin (Tf), which can mediate cellular iron uptake in vitro.	Iron	151-155	transferrin	Homo sapiens	30-32
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	100-104	transferrin	Homo sapiens	24-26
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	137-141	transferrin	Homo sapiens	24-26
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	137-141	transferrin	Homo sapiens	24-26
15473549-2	2004	The HNO3 reacts with silicates and possibly PO4(3-) species, releasing Al, Fe, nutrient base cations and H2PO4-, and is transformed into NO3-.	Iron	75-77	NBL1, DAN family BMP antagonist	Homo sapiens	5-8
15582280-1	2004	A growing body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with APP and Abeta amyloid may contribute to the Alzheimer"s amyloid pathology, and thus metal chelation could be a rational therapeutic approach for interdicting AD pathogenesis.	Iron	79-81	amyloid beta precursor protein	Homo sapiens	127-132
15625779-9	2004	Administration of L-Arg to Fe-treated groups prevented these reductions.	Iron	27-29	Rho guanine nucleotide exchange factor 12	Rattus norvegicus	18-23
15522424-0	2004	Phosphate ester hydrolysis is catalyzed by a bacterial transferrin: potential implications for in vivo iron transport mechanisms.	Iron	103-107	transferrin	Homo sapiens	55-66
15804829-0	2004	Reversible hexa- to penta-coordination of the heme Fe atom modulates ligand binding properties of neuroglobin and cytoglobin.	Iron	51-53	cytoglobin	Homo sapiens	114-124
15804829-7	2004	Reversible hexa- to penta-coordination of the heme Fe atom modulates ligand binding properties of Ngb and Cygb.	Iron	51-53	cytoglobin	Homo sapiens	106-110
15501773-3	2004	M. catarrhalis is a strict human respiratory pathogen, and this bacterium uses both transferrin and lactoferrin receptors to fulfill the essential iron requirement for survival in vivo.	Iron	147-151	transferrin	Homo sapiens	84-95
15804830-4	2004	Together with the observation that the distal ligand of the heme iron is the endogenous E7-histidine in both the ferric and ferrous form of neuroglobin and cytoglobin, the flexibility of the heme environment in neuroglobin will play a crucial role in the globins" ability to bind and stabilize exogenous ligands.	Iron	65-69	cytoglobin	Homo sapiens	156-166
15804833-4	2004	As with some plant and bacterial globins, neuroglobin and cytoglobin hemes are hexacoordinate in the absence of external ligands, in that the heme iron atom coordinates both a proximal and a distal His residue.	Iron	147-151	cytoglobin	Homo sapiens	58-68
15522410-0	2004	Release of iron from transferrin by phosphonocarboxylate and diphosphonate chelating agents.	Iron	11-15	transferrin	Homo sapiens	21-32
15522410-1	2004	The rates at which phosphonocarboxylate and diphosphonate ligands remove iron from the serum iron transport protein transferrin at 25 degrees C and pH 7.4 have been evaluated.	Iron	73-77	transferrin	Homo sapiens	116-127
15522410-1	2004	The rates at which phosphonocarboxylate and diphosphonate ligands remove iron from the serum iron transport protein transferrin at 25 degrees C and pH 7.4 have been evaluated.	Iron	93-97	transferrin	Homo sapiens	116-127
15522410-3	2004	The ability of the ligands to remove iron from transferrin appears to be subject to steric restrictions that are essentially identical to those associated with the ability of a ligand to substitute for the synergistic carbonate anion.	Iron	37-41	transferrin	Homo sapiens	47-58
15623339-5	2004	Flash photolysis studies revealed that the actual reductant in the reaction was a photogenerated BPNDI radical anion, which transferred an electron to the cyt c heme iron.	Iron	166-170	cytochrome c, somatic	Homo sapiens	155-160
15514286-3	2004	The inclusion of CRP as marker of infection allows for more accurate interpretation of VA and iron status.	Iron	94-98	C-reactive protein	Homo sapiens	17-20
15316097-13	2004	The independent negative relationship between serum ferritin and transferrin points to a specific process and suggests that increased production of ferritin may compensate for the loss of the iron-binding protein transferrin, thus reducing the amount of free iron.	Iron	192-196	transferrin	Homo sapiens	65-76
15316097-13	2004	The independent negative relationship between serum ferritin and transferrin points to a specific process and suggests that increased production of ferritin may compensate for the loss of the iron-binding protein transferrin, thus reducing the amount of free iron.	Iron	192-196	transferrin	Homo sapiens	213-224
15316097-13	2004	The independent negative relationship between serum ferritin and transferrin points to a specific process and suggests that increased production of ferritin may compensate for the loss of the iron-binding protein transferrin, thus reducing the amount of free iron.	Iron	259-263	transferrin	Homo sapiens	65-76
15651176-3	2004	Gallium shares certain chemical properties with iron; therefore, it binds avidly to the iron transport protein transferrin.	Iron	48-52	transferrin	Homo sapiens	111-122
15651176-6	2004	Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase.	Iron	125-129	transferrin	Homo sapiens	31-42
15514387-0	2004	Iron supplement in cancer patients receiving erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	45-59
15600258-11	2004	Patients with elevated cTnT levels received more IV iron than those with normal cTnT (3692+/-1771 vs. 1761+/-1595 mg, p&lt;0.001).	Iron	52-56	troponin T2, cardiac type	Homo sapiens	23-27
15831128-5	2004	Hephaestin, a caeruloplasmin homologue, works in concert with the IREG1 transporter to permit Fe efflux from enterocytes for loading onto transferrin.	Iron	94-96	transferrin	Homo sapiens	138-149
15600258-13	2004	Patients with elevated cTnT were longer on dialysis compared to those with normal levels (median times; 35.5 vs. 15 months, P&lt;0.01) and regression analysis identified the amount of administered iron as an independent factor for elevated cTnT (P&lt;0.01).	Iron	197-201	troponin T2, cardiac type	Homo sapiens	23-27
15600258-3	2004	In the present study, we investigated the relationship between cTnT concentration, IV iron treatment, and parameters of iron status.	Iron	120-124	troponin T2, cardiac type	Homo sapiens	63-67
15600258-13	2004	Patients with elevated cTnT were longer on dialysis compared to those with normal levels (median times; 35.5 vs. 15 months, P&lt;0.01) and regression analysis identified the amount of administered iron as an independent factor for elevated cTnT (P&lt;0.01).	Iron	197-201	troponin T2, cardiac type	Homo sapiens	240-244
15600258-14	2004	Intravenous iron treatment and high ferritin concentration are related to high cTnT level, which has previously been incriminated as a survival marker in hemodialysis patients.	Iron	12-16	troponin T2, cardiac type	Homo sapiens	79-83
15316013-1	2004	Iron regulatory protein 2 coordinates the cellular regulation of iron metabolism by binding to iron-responsive elements in mRNA.	Iron	65-69	iron responsive element binding protein 2	Homo sapiens	0-25
15316013-1	2004	Iron regulatory protein 2 coordinates the cellular regulation of iron metabolism by binding to iron-responsive elements in mRNA.	Iron	95-99	iron responsive element binding protein 2	Homo sapiens	0-25
15486292-3	2004	Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments.	Iron	189-193	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-68
15483706-6	2004	Quantum mechanical calculations (DFT) have been performed on 1a and 2a, in which the ligands employed are identical, and show the fac- to be marginally more stable than the mer-configuration for cobalt (1a) while for iron (2a) the converse is evident.	Iron	217-221	FA complementation group C	Homo sapiens	130-133
15469901-1	2004	Melanotransferrin (MTf) or melanoma tumor antigen p97 is a membrane-bound transferrin (Tf) homologue that binds iron (Fe).	Iron	112-116	transferrin	Rattus norvegicus	6-17
15469901-1	2004	Melanotransferrin (MTf) or melanoma tumor antigen p97 is a membrane-bound transferrin (Tf) homologue that binds iron (Fe).	Iron	118-120	transferrin	Rattus norvegicus	6-17
15469906-9	2004	Dcytb, DMT1, Ireg1 and transferrin receptor 1 mRNA expression in the spleen and liver of mice treated with PHZ responded to the enhanced iron demand associated with the resulting stimulation of erythropoiesis.	Iron	137-141	cytochrome b reductase 1	Mus musculus	0-5
15469906-9	2004	Dcytb, DMT1, Ireg1 and transferrin receptor 1 mRNA expression in the spleen and liver of mice treated with PHZ responded to the enhanced iron demand associated with the resulting stimulation of erythropoiesis.	Iron	137-141	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	13-18
15495089-14	2004	Haematological indices (haemoglobin and haemocrit) showed some increases when erythropoietin was compared to iron only, iron and folate, but not when compared with placebo.	Iron	120-124	erythropoietin	Homo sapiens	78-92
15363595-0	2004	Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways.	Iron	0-4	interleukin 6	Homo sapiens	13-26
15363595-0	2004	Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways.	Iron	0-4	mitogen-activated protein kinase 14	Homo sapiens	117-153
15363595-6	2004	Interestingly, the increase in AP-1 luciferase activity by iron was inhibited by the pretreatment of the cells with PD98059, a specific MEK1 inhibitor, and SB202190, a p38 kinase inhibitor.	Iron	59-63	mitogen-activated protein kinase 14	Homo sapiens	168-171
15363595-7	2004	Levels of interleukin-6 (IL-6), a pro-inflammatory cytokine, were increased in JB6 cells by iron in a dose-dependent manner.	Iron	92-96	interleukin 6	Homo sapiens	10-23
15363595-7	2004	Levels of interleukin-6 (IL-6), a pro-inflammatory cytokine, were increased in JB6 cells by iron in a dose-dependent manner.	Iron	92-96	interleukin 6	Homo sapiens	25-29
15363595-8	2004	The increase in IL-6 and its mRNA by iron was also eliminated by the pretreatment of the cells with PD98059 and SB202190.	Iron	37-41	interleukin 6	Homo sapiens	16-20
15363595-9	2004	Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload.	Iron	85-89	interleukin 6	Homo sapiens	10-14
15363595-9	2004	Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload.	Iron	85-89	interleukin 6	Homo sapiens	98-102
15363595-9	2004	Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload.	Iron	85-89	mitogen-activated protein kinase 14	Homo sapiens	152-155
15363595-9	2004	Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload.	Iron	236-240	interleukin 6	Homo sapiens	10-14
15363595-9	2004	Since the IL-6 promoter contains an AP-1 binding site, our studies indicate that the iron-induced IL-6 gene expression may be mediated through ERKs and p38 MAPK pathways, possibly one of the important mechanisms for the pathogenesis of iron overload.	Iron	236-240	interleukin 6	Homo sapiens	98-102
15486292-3	2004	Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments.	Iron	189-193	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-138
15486292-3	2004	Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments.	Iron	189-193	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-138
15486292-3	2004	Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments.	Iron	318-322	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-68
15532565-1	2004	Labeling of iron-free human serum transferrin by an amine-reactive probe, fluorescein isothiocyanate (FITC) was monitored with different dye to protein ratios.	Iron	12-16	transferrin	Homo sapiens	34-45
15178542-8	2004	Fetal iron status, as indexed by cord serum ferritin concentration, was inversely related to placental IRP-1 (r = -0.66, P &lt; 0.001) and IRP-2 (r = -0.42, P = 0.05) activities.	Iron	6-10	iron responsive element binding protein 2	Homo sapiens	139-144
15605992-5	2004	It was found that Abeta complexed with either iron or zinc was more toxic than Abeta alone.	Iron	46-50	amyloid beta precursor protein	Homo sapiens	18-23
15605992-7	2004	Surprisingly, we observed that when iron or copper were combined with Abeta, the neurotoxicity of these metals was substantially reduced, suggesting that Abeta may help to limit the toxicity of redox-active metal ions, thereby assisting the antioxidant defence of the brain.	Iron	36-40	amyloid beta precursor protein	Homo sapiens	154-159
15469598-4	2004	The administration of iron could be useful in the optimization of recombinant human erythropoietin activity, but this could be at the expense of bacterial proliferation.	Iron	22-26	erythropoietin	Homo sapiens	84-98
15473875-4	2004	Besides the impact of both phlebotomy treatment and GH on the rapid growth and mobilization of 20.8 g of iron in 136 weeks, the most relevant observation was the finding of a significant expansion of CD8+ T lymphocytes expressing the costimulatory marker CD28 in the setting of the severe lymphopenia.	Iron	105-109	growth hormone 1	Homo sapiens	52-54
15336316-3	2004	Iron(II)-glycine sulfate (Ferrosanol) and transferrin increased the cytotoxicity of free artesunate, artesunate microencapsulated in maltosyl-beta-cyclodextrin, and artemisinin toward CCRF-CEM leukemia and U373 astrocytoma cells 1.5- to 10.3-fold compared with that of artemisinins applied without iron.	Iron	298-302	transferrin	Homo sapiens	42-53
15451911-1	2004	OBJECTIVE: We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance.	Iron	46-50	insulin	Homo sapiens	87-94
15451911-8	2004	CONCLUSIONS: Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance.	Iron	22-26	insulin	Homo sapiens	116-123
15506212-0	2004	Chloride effect on TNT degradation by zerovalent iron or zinc during water treatment.	Iron	49-53	chromosome 16 open reading frame 82	Homo sapiens	19-22
15506212-1	2004	Addition of corrosion promoters, such as sodium and potassium chloride, accelerated TNT degradation during water treatment using zerovalent zinc and iron.	Iron	149-153	chromosome 16 open reading frame 82	Homo sapiens	84-87
15506212-5	2004	For the reaction with zerovalent iron and TNT, the rate constant increased from 6.5 (L/m2 x h) in the absence of KCl to 37 L x m(-2) x h(-1) using 3 mM KCl.	Iron	33-37	chromosome 16 open reading frame 82	Homo sapiens	42-45
15506212-9	2004	Zinc and iron scanning electron micrographs indicate that TNT degradation rate enhancement is caused by the pitting corrosion mechanism.	Iron	9-13	chromosome 16 open reading frame 82	Homo sapiens	58-61
15342464-4	2004	Dysregulation of Fpn1 and decreased iron levels in Pcm mutant spleens correlated with apoptotic cell death in the stroma, resulting in a semidominant spleen regression.	Iron	36-40	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	51-54
15373839-1	2004	In haem-regulated phosphodiesterase (PDE) from Escherichia coli (Ec DOS), haem is bound to the PAS domain, and the redox state of the haem iron regulates catalysis by the PDE domain.	Iron	139-143	phosphodiesterase	Escherichia coli	18-35
15373839-1	2004	In haem-regulated phosphodiesterase (PDE) from Escherichia coli (Ec DOS), haem is bound to the PAS domain, and the redox state of the haem iron regulates catalysis by the PDE domain.	Iron	139-143	phosphodiesterase	Escherichia coli	37-40
15373839-1	2004	In haem-regulated phosphodiesterase (PDE) from Escherichia coli (Ec DOS), haem is bound to the PAS domain, and the redox state of the haem iron regulates catalysis by the PDE domain.	Iron	139-143	phosphodiesterase	Escherichia coli	171-174
15373839-6	2004	Thus, Asp40 appears to play a critical role in the electronic structure of the haem iron and redox-dependent catalytic control of the PDE domain.	Iron	84-88	phosphodiesterase	Escherichia coli	134-137
15336316-7	2004	The effect of ferrous iron and transferrin was reversed by monoclonal antibody RVS10 against the transferrin receptor (TfR), which competes with transferrin for binding to TfR.	Iron	22-26	transferrin	Homo sapiens	97-108
15281088-3	2004	In human serum, about 30% of Tf exists in the iron-saturated form (Fe(2)-Tf) and the remainder exists as apotransferrin (apo-Tf).	Iron	46-50	transferrin	Homo sapiens	29-31
15477198-1	2004	BACKGROUND AND OBJECTIVES: Hemochromatosis is a genetic disorder characterized by progressive iron overload which leads to early abnormalities of iron parameters (increased transferrin saturation =TS and serum ferritin=SF) and late clinical complications.	Iron	94-98	transferrin	Homo sapiens	173-184
15292463-0	2004	Oxidative stress induced by iron released from transferrin in low pH peritoneal dialysis solution.	Iron	28-32	transferrin	Homo sapiens	47-58
15378409-5	2004	At pH 7.0, rabbit ferrous HPX-heme-NO is a six-coordinate heme-iron species, characterized by an X-band EPR spectrum with an axial geometry and by epsilon=146 mM(-1) cm(-1) at 419 nm.	Iron	63-67	hemopexin	Oryctolagus cuniculus	26-29
15378409-6	2004	At pH 4.0, rabbit ferrous HPX-heme-NO is a five-coordinate heme-iron species, characterized by an X-band EPR spectrum with three-line splitting centered at 334 mT and by epsilon=74 mM(-1) cm(-1) at 387 nm.	Iron	64-68	hemopexin	Oryctolagus cuniculus	26-29
15626156-0	2004	Efficacy of human recombinant erythropoietin plus IFN-alpha in patients affected by chronic hepatitis C. Determination of serum iron levels in patients affected by chronic hepatitis C is considered fundamental for studying the response to interferon-alpha (IFN-alpha) treatment.	Iron	128-132	erythropoietin	Homo sapiens	30-44
15626156-0	2004	Efficacy of human recombinant erythropoietin plus IFN-alpha in patients affected by chronic hepatitis C. Determination of serum iron levels in patients affected by chronic hepatitis C is considered fundamental for studying the response to interferon-alpha (IFN-alpha) treatment.	Iron	128-132	interferon alpha 1	Homo sapiens	50-59
15626156-11	2004	Our study confirms the important role played by iron in the response to IFN treatment, suggesting that the use of rHuEPO induces a better response to IFN in patients with chronic hepatitis C by activation of erythropoiesis.	Iron	48-52	interferon alpha 1	Homo sapiens	72-75
15482345-1	2004	GOAL: We evaluated the effect of venesections and restricted diet on iron and metabolic indices and liver function tests in patients with insulin-resistance hepatic iron overload (IR-HIO).	Iron	165-169	insulin	Homo sapiens	138-145
15482345-10	2004	Data suggest a relationship between hepatic iron overload and insulin resistance, and a role for both iron overload and insulin resistance in hepatocellular damage.	Iron	44-48	insulin	Homo sapiens	62-69
15292463-5	2004	Oxidative stress induced by iron released from transferrin was evaluated in terms of the formation of thiobarbituric acid reactive substance (TBARS) and protein carbonylation in the human red blood cell (RBC) membrane.	Iron	28-32	transferrin	Homo sapiens	47-58
15292463-7	2004	RESULTS: Low pH PD solution released iron from transferrin.	Iron	37-41	transferrin	Homo sapiens	47-58
15292463-10	2004	Iron released from transferrin in low pH PD solution increased TBARS formation and protein carbonylation in the human RBC membrane.	Iron	0-4	transferrin	Homo sapiens	19-30
15456844-4	2004	Iron depletion induces DNA double-strand breaks in treated cells, and activates a DNA damage response that results in focal phosphorylation of histone H2AX, focal accumulation of replication protein A (RPA) and ATR (ATM and Rad3-related kinase), and activation of CHK1 kinase.	Iron	0-4	checkpoint kinase 1	Homo sapiens	264-268
15543948-0	2004	Modulation of iron on mitochondrial aconitase expression in human prostatic carcinoma cells.	Iron	14-18	aconitase 2	Homo sapiens	22-45
15292463-12	2004	CONCLUSIONS: Iron released from transferrin in low pH PD solution can produce oxidative stress in the peritoneum of a PD patient.	Iron	13-17	transferrin	Homo sapiens	32-43
15292463-1	2004	BACKGROUND: Transferrin binds extracellular iron and protects tissues from iron-induced oxidative stress.	Iron	44-48	transferrin	Homo sapiens	12-23
15292463-1	2004	BACKGROUND: Transferrin binds extracellular iron and protects tissues from iron-induced oxidative stress.	Iron	75-79	transferrin	Homo sapiens	12-23
15292463-4	2004	METHODS: Effects of PD solutions on iron binding to transferrin were examined with purified human transferrin and transferrin in dialysates drained from PD patients.	Iron	36-40	transferrin	Homo sapiens	52-63
15350145-3	2004	We recently demonstrated that MPO heme reduction causes collapse of the heme pocket, as monitored by significant reductions in the rates of diatomic ligand binding to the heme iron.	Iron	176-180	myeloperoxidase	Homo sapiens	30-33
15287097-1	2004	BACKGROUND: Mitochondrial aconitase (mACON), an iron-requiring enzyme, is a major target of nitric oxide (NO) in cells, which causes the oxidant-mediated disruption of the [4Fe-4S] prosthetic group of the enzyme.	Iron	48-52	aconitase 2	Homo sapiens	12-35
15327944-1	2004	Ferritin is the major iron storage protein regulating cytosolic concentration of iron by storing excess iron.	Iron	22-26	Ferritin	Caenorhabditis elegans	0-8
15327944-1	2004	Ferritin is the major iron storage protein regulating cytosolic concentration of iron by storing excess iron.	Iron	81-85	Ferritin	Caenorhabditis elegans	0-8
15327944-1	2004	Ferritin is the major iron storage protein regulating cytosolic concentration of iron by storing excess iron.	Iron	81-85	Ferritin	Caenorhabditis elegans	0-8
15327944-5	2004	Cytosolic aconitase (aco-1), iron regulatory protein, is known to regulate cellular iron concentration by modulating translation of the ferritin mRNA in addition to its enzymatic activity that converts citrate into iso-citrate.	Iron	29-33	Ferritin	Caenorhabditis elegans	136-144
15220329-8	2004	We conclude that Mito-Q or MitoVit-E supplementation of endothelial cells mitigates peroxide-mediated oxidant stress and maintains proteasomal function, resulting in the overall inhibition of TfR-dependent iron uptake and apoptosis.	Iron	206-210	transferrin receptor	Bos taurus	192-195
15313158-10	2004	Iron treatment also reduced various antioxidant enzymes like glutathione peroxidase (GSHPx), catalase, and superoxide dismutase (SOD).	Iron	0-4	catalase	Homo sapiens	93-101
15247288-0	2004	IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions.	Iron	14-18	iron-sulfur cluster assembly enzyme	Homo sapiens	68-72
15247288-0	2004	IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions.	Iron	44-48	iron-sulfur cluster assembly enzyme	Homo sapiens	68-72
15247288-0	2004	IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions.	Iron	44-48	iron-sulfur cluster assembly enzyme	Homo sapiens	68-72
15247288-1	2004	Increasing evidence suggests that IscS, a cysteine desulfurase, provides sulfur for assembly of transient iron-sulfur clusters in IscU.	Iron	106-110	iron-sulfur cluster assembly enzyme	Homo sapiens	130-134
15247288-4	2004	Here we find that Escherichia coli IscU fails to assemble iron-sulfur clusters when the accessible "free" iron in solution is limited by an iron chelator sodium citrate.	Iron	58-62	iron-sulfur cluster assembly enzyme	Homo sapiens	35-39
15247288-4	2004	Here we find that Escherichia coli IscU fails to assemble iron-sulfur clusters when the accessible "free" iron in solution is limited by an iron chelator sodium citrate.	Iron	106-110	iron-sulfur cluster assembly enzyme	Homo sapiens	35-39
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	21-25	iron-sulfur cluster assembly enzyme	Homo sapiens	248-252
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	iron-sulfur cluster assembly enzyme	Homo sapiens	248-252
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	iron-sulfur cluster assembly enzyme	Homo sapiens	248-252
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	iron-sulfur cluster assembly enzyme	Homo sapiens	248-252
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	iron-sulfur cluster assembly enzyme	Homo sapiens	248-252
15247288-8	2004	The results suggest that IscA is capable of recruiting intracellular iron and providing iron for the iron-sulfur cluster assembly in IscU in cells in which the accessible "free" iron content is probably restricted.	Iron	88-92	iron-sulfur cluster assembly enzyme	Homo sapiens	133-137
15247288-8	2004	The results suggest that IscA is capable of recruiting intracellular iron and providing iron for the iron-sulfur cluster assembly in IscU in cells in which the accessible "free" iron content is probably restricted.	Iron	88-92	iron-sulfur cluster assembly enzyme	Homo sapiens	133-137
15247288-8	2004	The results suggest that IscA is capable of recruiting intracellular iron and providing iron for the iron-sulfur cluster assembly in IscU in cells in which the accessible "free" iron content is probably restricted.	Iron	88-92	iron-sulfur cluster assembly enzyme	Homo sapiens	133-137
15321958-1	2004	OBJECTIVE: To confirm the increase in non-transferrin bound iron (NTBI) after packed red cell (PRC) transfusion and to evaluate the association with increased oxidative stress in preterm infants.	Iron	60-64	transferrin	Homo sapiens	42-53
15334240-6	2004	This is due to a gliosis (increased signal) and accumulation of surrounding iron (decreased signal intensity) in long TR sequences.	Iron	76-80	coagulation factor II thrombin receptor	Homo sapiens	118-120
15368155-1	2004	BACKGROUND AND OBJECTIVE: Iron deficiency limits the efficacy of recombinant human erythropoietin (rhEPO) therapy in end-stage renal disease patients.	Iron	26-30	erythropoietin	Homo sapiens	83-97
15231685-6	2004	RESULTS: Fe3+ binding was highest when Tf was incubated with Fe:nitrilotriacetic acid and reached a steady state overnight.	Iron	9-11	transferrin	Homo sapiens	39-41
15313158-10	2004	Iron treatment also reduced various antioxidant enzymes like glutathione peroxidase (GSHPx), catalase, and superoxide dismutase (SOD).	Iron	0-4	superoxide dismutase 1	Homo sapiens	107-127
15313158-10	2004	Iron treatment also reduced various antioxidant enzymes like glutathione peroxidase (GSHPx), catalase, and superoxide dismutase (SOD).	Iron	0-4	superoxide dismutase 1	Homo sapiens	129-132
15377970-0	2004	Response of soluble transferrin receptor and iron-related parameters to iron supplementation in elite, iron-depleted, nonanemic female athletes.	Iron	72-76	transferrin	Homo sapiens	20-31
15377970-0	2004	Response of soluble transferrin receptor and iron-related parameters to iron supplementation in elite, iron-depleted, nonanemic female athletes.	Iron	72-76	transferrin	Homo sapiens	20-31
21706744-4	2004	Ngb and Cygb display the classical three-on-three alpha-helical globin fold and are endowed with a hexa-coordinate heme Fe atom, in both their ferrous and ferric forms, having the heme distal HisE7 residue as the endogenous sixth ligand.	Iron	120-122	cytoglobin	Homo sapiens	8-12
21706744-5	2004	Reversible intramolecular hexa- to penta-coordination of the heme Fe atom modulates Ngb and Cygb ligand-binding properties.	Iron	66-68	cytoglobin	Homo sapiens	92-96
15480904-1	2004	BACKGROUND: Reticulocyte hemoglobin content (CHr) has recently become available as a direct marker of the iron status in hemodialysis patients undergoing recombinant human erythropoietin (rHuEPO) therapy.	Iron	106-110	erythropoietin	Homo sapiens	172-186
15288128-3	2004	Consistent with its role in metal metabolism, inhibition of Fre1 by NO also inhibited yeast growth in low-iron medium.	Iron	106-110	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	60-64
15700767-8	2004	Serum AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels were significantly higher in CCl4-treated rats than in the controls, while urea, total protein, and albumin levels were significantly lower.	Iron	73-77	C-C motif chemokine ligand 4	Rattus norvegicus	114-118
15312163-6	2004	MPTP-induced mitochondrial aconitase inactivation, iron accumulation and dopamine depletion were significantly attenuated in transgenic mice overexpressing mitochondrial Sod2 and exacerbated in partial deficient Sod2 mice.	Iron	51-55	superoxide dismutase 2, mitochondrial	Mus musculus	170-174
15675724-3	2004	Iron metabolism related components and the dopaminergic system have been extensively investigated in respect to the pathophysiology of RLS.	Iron	0-4	RLS1	Homo sapiens	135-138
15700767-10	2004	However, the elevations in AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels induced by CCl4 injections were significantly reduced by melatonin.	Iron	94-98	C-C motif chemokine ligand 4	Rattus norvegicus	117-121
15470280-16	2004	Significant rise in MCV and MCH in normal group indicated that even this apparently normal group had iron deficient erythropoiesis.	Iron	101-105	pro-melanin concentrating hormone	Homo sapiens	28-31
15310833-0	2004	FRD3 controls iron localization in Arabidopsis.	Iron	14-18	MATE efflux family protein	Arabidopsis thaliana	0-4
15310833-1	2004	The frd3 mutant of Arabidopsis exhibits constitutive expression of its iron uptake responses and is chlorotic.	Iron	71-75	MATE efflux family protein	Arabidopsis thaliana	4-8
15310833-3	2004	Here we present several experiments demonstrating that a functional FRD3 gene is necessary for correct iron localization in both the root and shoot of Arabidopsis plants.	Iron	103-107	MATE efflux family protein	Arabidopsis thaliana	68-72
15384908-10	2004	For instance, on d 6 in experiment 2, poults fed the PDH had poorer FE (P &lt; 0.05) compared with the control PD treatment, but had similar FE to poults fed the PD in experiment 1.	Iron	68-70	proline dehydrogenase	Glycine max	53-56
15310833-5	2004	This indicates that FRD3 function is root-specific and points to a role for FRD3 in delivering iron to the shoot in a usable form.	Iron	95-99	MATE efflux family protein	Arabidopsis thaliana	20-24
15310833-5	2004	This indicates that FRD3 function is root-specific and points to a role for FRD3 in delivering iron to the shoot in a usable form.	Iron	95-99	MATE efflux family protein	Arabidopsis thaliana	76-80
15310833-6	2004	When grown under certain conditions, frd3 mutant plants overaccumulate iron in their shoot tissues.	Iron	71-75	MATE efflux family protein	Arabidopsis thaliana	37-41
15310833-7	2004	However, we demonstrate by direct measurement of iron levels in shoot protoplasts that intracellular iron levels in frd3 are only about one-half the levels in wild type.	Iron	101-105	MATE efflux family protein	Arabidopsis thaliana	116-120
15310833-8	2004	Histochemical staining for iron reveals that frd3 mutants accumulate high levels of ferric iron in their root vascular cylinder, the same tissues in which the FRD3 gene is expressed.	Iron	27-31	MATE efflux family protein	Arabidopsis thaliana	45-49
15310833-9	2004	Taken together, these results clearly indicate a role for FRD3 in iron localization in Arabidopsis.	Iron	66-70	MATE efflux family protein	Arabidopsis thaliana	58-62
15310833-10	2004	Specifically, FRD3 is likely to function in root xylem loading of an iron chelator or other factor necessary for efficient iron uptake out of the xylem or apoplastic space and into leaf cells.	Iron	69-73	MATE efflux family protein	Arabidopsis thaliana	14-18
15310833-10	2004	Specifically, FRD3 is likely to function in root xylem loading of an iron chelator or other factor necessary for efficient iron uptake out of the xylem or apoplastic space and into leaf cells.	Iron	123-127	MATE efflux family protein	Arabidopsis thaliana	14-18
15498246-0	2004	[Effects of iron supplementation on human serum level of transferrin receptor].	Iron	12-16	transferrin	Homo sapiens	57-68
15340179-7	2004	Transferrin may be involved in the physiological transport of iron and manganese into the brain and their utilization there.	Iron	62-66	transferrin	Homo sapiens	0-11
15340179-8	2004	It is reported that the brain transferrin concentration is decreased in neurodegenerative diseases such as Alzheimer"s disease and Parkinson"s disease and that brain iron metabolism is also altered.	Iron	166-170	transferrin	Homo sapiens	30-41
15498246-1	2004	OBJECTIVE: To study trend of dynamic change in level of serum transferrin receptor (sTfR) in the process of iron supplementation to provide evidence for sTfR in evaluating the efficacy of iron supplementation.	Iron	108-112	transferrin	Homo sapiens	62-73
15498246-1	2004	OBJECTIVE: To study trend of dynamic change in level of serum transferrin receptor (sTfR) in the process of iron supplementation to provide evidence for sTfR in evaluating the efficacy of iron supplementation.	Iron	188-192	transferrin	Homo sapiens	62-73
15327997-5	2004	Our data suggest that TNFalpha could regulate dietary iron absorption and that the apical transport machinery is the target for these actions.	Iron	54-58	tumor necrosis factor	Homo sapiens	22-30
15220327-1	2004	Previous studies have indicated that the essential protein Nfs1 performs a crucial role in cellular iron-sulfur (Fe/S) protein maturation.	Iron	113-115	cysteine desulfurase	Saccharomyces cerevisiae S288C	59-63
15327995-0	2004	The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin.	Iron	21-25	transferrin	Homo sapiens	111-122
15161905-3	2004	Overexpression of MRS3 or MRS4 suppresses the high iron sensitivity of Deltaccc1 cells.	Iron	51-55	Fe(2+) transporter	Saccharomyces cerevisiae S288C	18-22
15327995-0	2004	The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin.	Iron	71-75	transferrin	Homo sapiens	111-122
15327995-4	2004	These data indicate that Tyr188 is a critical residue not only for iron binding but also for chelator binding and iron release in transferrin.	Iron	67-71	transferrin	Homo sapiens	130-141
15327995-4	2004	These data indicate that Tyr188 is a critical residue not only for iron binding but also for chelator binding and iron release in transferrin.	Iron	114-118	transferrin	Homo sapiens	130-141
15327997-1	2004	TNFalpha has dramatic effects on iron metabolism contributing to the generation of hypoferraemia in the anaemia of chronic disease.	Iron	33-37	tumor necrosis factor	Homo sapiens	0-8
15327997-2	2004	Interestingly, TNFalpha is also synthesised and released within the intestinal mucosa, suggesting that this pro-inflammatory cytokine may play a role in regulating dietary iron absorption.	Iron	172-176	tumor necrosis factor	Homo sapiens	15-23
15327997-4	2004	In TNFalpha-treated cells, apical iron uptake was significantly decreased and this was accompanied by a reduction in divalent metal transporter protein and mRNA expression.	Iron	34-38	tumor necrosis factor	Homo sapiens	3-11
15169765-5	2004	HIF-dependent changes in candidate target gene expression were detected through variously effective stimuli: hypoxia (strong) &gt; iron chelation, e.g. desferrioxamine (moderate) &gt;&gt; transition metals, e.g. cobalt approximately normoxia (ineffective).	Iron	131-135	similar	Drosophila melanogaster	0-3
15461737-1	2004	Intravenous iron treatment in hemodialysis patients improves the response to recombinant human erythropoietin (rHuEPO) and facilitates achievement of targets for hemoglobin and hematocrit.	Iron	12-16	erythropoietin	Homo sapiens	95-109
15161905-5	2004	We demonstrate that deletion of MRS3 and MRS4 severely affects cellular and mitochondrial metal homeostasis, including a reduction in cytosolic and mitochondrial iron acquisition.	Iron	162-166	Fe(2+) transporter	Saccharomyces cerevisiae S288C	32-36
15305020-2	2004	In the present study, we investigated whether the entering of indium-111 (111In) and iron-59 (59Fe) with high affinity to transferrin differed from the entering of 67Ga by the hepatocytes after partial hepatectomy.	Iron	85-89	transferrin	Rattus norvegicus	122-133
15318094-2	2004	Recently, we reported that the expression of transferrin receptor, which mediates cellular iron uptake, was increased in hepatocytes in patients with alcoholic liver disease.	Iron	91-95	transferrin	Homo sapiens	45-56
15318094-5	2004	RESULTS: Ethanol exposure to the hepatocytes demonstrated an ~2-fold increase in transferrin receptor expression for 24 hr, shown by Western blot analysis and S-methionine metabolic labeling, 19% increase in Fe-transferrin uptake by hepatocytes, and 20% increase in activity of iron regulatory protein examined by band shift assay.	Iron	208-210	transferrin	Rattus norvegicus	81-92
15318094-5	2004	RESULTS: Ethanol exposure to the hepatocytes demonstrated an ~2-fold increase in transferrin receptor expression for 24 hr, shown by Western blot analysis and S-methionine metabolic labeling, 19% increase in Fe-transferrin uptake by hepatocytes, and 20% increase in activity of iron regulatory protein examined by band shift assay.	Iron	278-282	transferrin	Rattus norvegicus	81-92
15318094-7	2004	The induction of transferrin receptor by ethanol might be one of the mechanisms of iron accumulation in the hepatocytes in alcoholic liver disease.	Iron	83-87	transferrin	Rattus norvegicus	17-28
15259365-7	2004	The results demonstrated that AZT and AZTMP were uneffective as iron chelators, while AZTTP displayed a significant capacity to remove iron from transferrin (Tf).	Iron	135-139	transferrin	Homo sapiens	145-156
15259365-7	2004	The results demonstrated that AZT and AZTMP were uneffective as iron chelators, while AZTTP displayed a significant capacity to remove iron from transferrin (Tf).	Iron	135-139	transferrin	Homo sapiens	158-160
15270200-5	2004	At the biochemical level, copper, zinc and iron were shown to accelerate the aggregation of the Abeta peptide and enhance metal catalyzed oxidative stress associated with amyloid plaque formation.	Iron	43-47	amyloid beta precursor protein	Homo sapiens	96-101
15212902-6	2004	High concentrations of surface ferrous iron in a dithionite reduced sediment degraded CL-20 the fastest (half-life &lt; 0.05 h), but 2:1 clays containing no structural or adsorbed ferrous iron (hectorite) could also quickly degrade CL-20 (half-life &lt; 0.2 h).	Iron	31-43	epithelial membrane protein 1	Homo sapiens	86-91
15212902-6	2004	High concentrations of surface ferrous iron in a dithionite reduced sediment degraded CL-20 the fastest (half-life &lt; 0.05 h), but 2:1 clays containing no structural or adsorbed ferrous iron (hectorite) could also quickly degrade CL-20 (half-life &lt; 0.2 h).	Iron	31-43	epithelial membrane protein 1	Homo sapiens	232-237
15212902-6	2004	High concentrations of surface ferrous iron in a dithionite reduced sediment degraded CL-20 the fastest (half-life &lt; 0.05 h), but 2:1 clays containing no structural or adsorbed ferrous iron (hectorite) could also quickly degrade CL-20 (half-life &lt; 0.2 h).	Iron	39-43	epithelial membrane protein 1	Homo sapiens	86-91
15212902-6	2004	High concentrations of surface ferrous iron in a dithionite reduced sediment degraded CL-20 the fastest (half-life &lt; 0.05 h), but 2:1 clays containing no structural or adsorbed ferrous iron (hectorite) could also quickly degrade CL-20 (half-life &lt; 0.2 h).	Iron	39-43	epithelial membrane protein 1	Homo sapiens	232-237
15271890-2	2004	The aims of this study were to investigate the degradation of human transferrin by gingipain cysteine proteinases of P. gingivalis and to demonstrate the production of toxic hydroxyl radicals (HO*) catalyzed by the iron-containing transferrin fragments generated or by release of iron itself.	Iron	215-219	transferrin	Homo sapiens	68-79
15332399-3	2004	The current authors also determined sputum interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha levels because of their putative role in intracellular iron homeostasis.	Iron	160-164	tumor necrosis factor	Homo sapiens	70-104
15492480-0	2004	Role of aberrant iron homeostasis in the upregulation of transforming growth factor-beta1 in the kidney of angiotensin II-induced hypertensive rats.	Iron	17-21	transforming growth factor, beta 1	Rattus norvegicus	57-89
15492480-0	2004	Role of aberrant iron homeostasis in the upregulation of transforming growth factor-beta1 in the kidney of angiotensin II-induced hypertensive rats.	Iron	17-21	angiotensinogen	Rattus norvegicus	107-121
15492480-1	2004	We have previously shown that abnormal iron metabolism might be one underlying mechanism of the renal damage observed in the angiotensin II-infused rat.	Iron	39-43	angiotensinogen	Rattus norvegicus	125-139
15492480-3	2004	The purpose of the present study was to examine the effects of an iron chelator and a free radical scavenger on the angiotensin II-induced upregulation of TGF-beta1 in the kidney.	Iron	66-70	angiotensinogen	Rattus norvegicus	116-130
15492480-3	2004	The purpose of the present study was to examine the effects of an iron chelator and a free radical scavenger on the angiotensin II-induced upregulation of TGF-beta1 in the kidney.	Iron	66-70	transforming growth factor, beta 1	Rattus norvegicus	155-164
15492480-7	2004	Although tubular cells that overexpressed TGF-beta1 did not contain iron particles, angiotensin II-induced TGF-beta1 upregulation was suppressed by the iron chelator and the free radical scavenger.	Iron	152-156	transforming growth factor, beta 1	Rattus norvegicus	42-51
15492480-7	2004	Although tubular cells that overexpressed TGF-beta1 did not contain iron particles, angiotensin II-induced TGF-beta1 upregulation was suppressed by the iron chelator and the free radical scavenger.	Iron	152-156	angiotensinogen	Rattus norvegicus	84-98
15492480-7	2004	Although tubular cells that overexpressed TGF-beta1 did not contain iron particles, angiotensin II-induced TGF-beta1 upregulation was suppressed by the iron chelator and the free radical scavenger.	Iron	152-156	transforming growth factor, beta 1	Rattus norvegicus	107-116
15492480-10	2004	Collectively, these data suggest that the renal iron overload and presumed subsequent increase in oxidative stress play a role in angiotensin II-induced upregulation of the mRNAs of TGF-beta1 and collagen types I and IV in the kidney.	Iron	48-52	angiotensinogen	Rattus norvegicus	130-144
15492480-10	2004	Collectively, these data suggest that the renal iron overload and presumed subsequent increase in oxidative stress play a role in angiotensin II-induced upregulation of the mRNAs of TGF-beta1 and collagen types I and IV in the kidney.	Iron	48-52	transforming growth factor, beta 1	Rattus norvegicus	182-191
15524266-3	2004	Host iron can be acquired by several mechanisms, e.g. from hemoglobin degradation products such as heme and hemin, directly from ferrated transferrin and lactoferrin, indirectly from iron binding proteins by the production of siderophores and from intracellular iron stores (ferritin).	Iron	5-9	transferrin	Homo sapiens	138-149
15332399-7	2004	In the CF patients, sputum iron was positively and strongly related to IL-1beta, TNF-alpha, ferritin and microalbumin levels, but negatively related to forced expiratory volume in one second % predicted.	Iron	27-31	interleukin 1 beta	Homo sapiens	71-79
15332399-7	2004	In the CF patients, sputum iron was positively and strongly related to IL-1beta, TNF-alpha, ferritin and microalbumin levels, but negatively related to forced expiratory volume in one second % predicted.	Iron	27-31	tumor necrosis factor	Homo sapiens	81-90
15332399-9	2004	However, changes in sputum TNF-alpha in acute patients were still closely related to changes in iron, ferritin and albumin content, and changes in IL-1beta were related to changes in sputum ferritin content.	Iron	96-100	tumor necrosis factor	Homo sapiens	27-36
15271890-2	2004	The aims of this study were to investigate the degradation of human transferrin by gingipain cysteine proteinases of P. gingivalis and to demonstrate the production of toxic hydroxyl radicals (HO*) catalyzed by the iron-containing transferrin fragments generated or by release of iron itself.	Iron	215-219	transferrin	Homo sapiens	231-242
15271890-2	2004	The aims of this study were to investigate the degradation of human transferrin by gingipain cysteine proteinases of P. gingivalis and to demonstrate the production of toxic hydroxyl radicals (HO*) catalyzed by the iron-containing transferrin fragments generated or by release of iron itself.	Iron	280-284	transferrin	Homo sapiens	68-79
15271890-2	2004	The aims of this study were to investigate the degradation of human transferrin by gingipain cysteine proteinases of P. gingivalis and to demonstrate the production of toxic hydroxyl radicals (HO*) catalyzed by the iron-containing transferrin fragments generated or by release of iron itself.	Iron	280-284	transferrin	Homo sapiens	231-242
15271890-3	2004	Analysis by polyacrylamide gel electrophoresis and Western immunoblotting showed that preparations of Arg- and Lys-gingipains of P. gingivalis cleave transferrin (iron-free and iron-saturated forms) into fragments of various sizes.	Iron	163-167	transferrin	Homo sapiens	150-161
15271890-6	2004	Subsequent to the degradation of transferrin, bacterial cells assimilated intracellularly the radiolabeled iron.	Iron	107-111	transferrin	Homo sapiens	33-44
15271890-7	2004	Growth of P. gingivalis ATCC 33277, but not growth of an Arg-gingipain- and Lys-gingipain-deficient mutant, was possible in a chemically defined medium containing 30% iron-saturated transferrin as the only source of iron and peptides, suggesting that gingipains play a critical role in the acquisition of essential growth nutrients.	Iron	167-171	transferrin	Homo sapiens	182-193
15271890-9	2004	Our study indicates that P. gingivalis gingipains degrade human transferrin, providing sources of iron and peptides.	Iron	98-102	transferrin	Homo sapiens	64-75
15271890-10	2004	The iron-containing transferrin fragments or the release of iron itself may contribute to tissue destruction by catalyzing the formation of toxic HO*.	Iron	4-8	transferrin	Homo sapiens	20-31
15122306-4	2004	We show here that reactive oxygen species (ROS), generated by the iron in chrysotile or crocidolite asbestos, mediate the biological activity of TGF-beta1.	Iron	66-70	transforming growth factor beta 1	Homo sapiens	145-154
15155756-0	2004	Two distinct binding sites for high potential iron-sulfur protein and cytochrome c on the reaction center-bound cytochrome of Rubrivivax gelatinosus.	Iron	46-50	cytochrome c, somatic	Homo sapiens	70-82
15249056-1	2004	Transferrin is a bilobal protein with the ability to bind iron in two binding sites situated at the bottom of a cleft in each lobe.	Iron	58-62	transferrin	Homo sapiens	0-11
15253741-0	2004	Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients.	Iron	12-16	albumin	Homo sapiens	59-66
15294189-2	2004	BACKGROUND: Transferrin receptor mediates cellular uptake of iron, and the expression on cells reflects iron needs and erythropoietic activity.	Iron	61-65	transferrin	Homo sapiens	12-23
15294189-2	2004	BACKGROUND: Transferrin receptor mediates cellular uptake of iron, and the expression on cells reflects iron needs and erythropoietic activity.	Iron	104-108	transferrin	Homo sapiens	12-23
15257597-8	2004	Following this procedure, the first azadithiolate-bridged dinuclear iron complex coordinated by a phosphine ligand [(mu-ADT)Fe2(CO)5PPh3] (4, R = 4-bromophenyl) was synthesized.	Iron	68-72	caveolin 1	Homo sapiens	132-136
15240108-1	2004	Heme oxygenase-1 (HO-1) degrades heme into biliverdin, iron, and CO.	Iron	55-59	heme oxygenase 1	Mus musculus	0-16
15240108-1	2004	Heme oxygenase-1 (HO-1) degrades heme into biliverdin, iron, and CO.	Iron	55-59	heme oxygenase 1	Mus musculus	18-22
15133041-0	2004	Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae.	Iron	86-90	Cti6p	Saccharomyces cerevisiae S288C	0-4
15133041-6	2004	In this report we show that CTI6 mRNA levels are increased under iron-limiting conditions, and that cti6 mutants display a growth defect under conditions of iron deprivation.	Iron	157-161	Cti6p	Saccharomyces cerevisiae S288C	100-104
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Iron	53-57	Cti6p	Saccharomyces cerevisiae S288C	28-32
15133041-0	2004	Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae.	Iron	86-90	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	11-15
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Iron	183-187	Cti6p	Saccharomyces cerevisiae S288C	28-32
15133041-10	2004	Taken together, these data suggest a specific role for Cti6 in the regulation of gene expression under conditions of iron limitation.	Iron	117-121	Cti6p	Saccharomyces cerevisiae S288C	55-59
15133041-4	2004	To further identify genes that function in iron and copper homeostasis, we screened for novel yeast mutants defective for iron limiting growth and thereby identified the CTI6 gene.	Iron	43-47	Cti6p	Saccharomyces cerevisiae S288C	170-174
15133041-4	2004	To further identify genes that function in iron and copper homeostasis, we screened for novel yeast mutants defective for iron limiting growth and thereby identified the CTI6 gene.	Iron	122-126	Cti6p	Saccharomyces cerevisiae S288C	170-174
15133041-6	2004	In this report we show that CTI6 mRNA levels are increased under iron-limiting conditions, and that cti6 mutants display a growth defect under conditions of iron deprivation.	Iron	65-69	Cti6p	Saccharomyces cerevisiae S288C	28-32
15231239-4	2004	These findings indicate aberrations in iron homeostasis that, we suspect, arise primarily from heme, since heme oxygenase-1, an enzyme that catalyzes the conversion of heme to iron and biliverdin, is increased in AD, and mitochondria, since mitochondria turnover, mitochondrial DNA, and cytochrome C oxidative activity are all increased in AD.	Iron	39-43	cytochrome c, somatic	Homo sapiens	287-299
15123690-1	2004	Isu, the scaffold for assembly of Fe-S clusters in the yeast mitochondrial matrix, is a substrate protein for the Hsp70 Ssq1 and the J-protein Jac1 in vitro.	Iron	34-38	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	120-124
15123690-5	2004	We conclude that the Ssq1-Isu substrate interaction is critical for Fe-S cluster biogenesis in vivo.	Iron	68-72	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	21-25
15100228-1	2004	HscA, a specialized bacterial hsp70-class chaperone, interacts with the iron-sulfur cluster assembly protein IscU by recognizing a conserved LPPVK sequence motif at positions 99-103.	Iron	72-76	iron-sulfur cluster assembly enzyme	Rattus norvegicus	109-113
15196668-0	2004	Endogenous glutathione and catalase protect cultured rat astrocytes from the iron-mediated toxicity of hydrogen peroxide.	Iron	77-81	catalase	Rattus norvegicus	27-35
15293395-3	2004	The collision cell option of the ICP-MS instrument method was used to improve the performance of the instrument for iron measurements since ArO and ArN interferences could be reduced using this analytical method.	Iron	116-120	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	140-143
15211443-15	2004	Even in some countries with high intravenous iron use, 35% to 40% of patients had a transferrin saturation less than 20% (below guidelines).	Iron	45-49	transferrin	Homo sapiens	84-95
14658011-3	2004	Furthermore, combined therapy with L1 and DFX produced an additive or synergistic iron chelating effect.	Iron	82-86	immunoglobulin kappa variable 1-16	Homo sapiens	35-45
15487708-0	2004	Association of serum insulin-like growth factor-I and erythropoiesis in relation to body iron status.	Iron	89-93	insulin like growth factor 1	Homo sapiens	21-49
15487708-1	2004	This study investigated the associations between serum insulin-like growth factor-I (IGF-I) concentrations and erythropoietic activities in relation to body iron status.	Iron	157-161	insulin like growth factor 1	Homo sapiens	55-83
15487708-1	2004	This study investigated the associations between serum insulin-like growth factor-I (IGF-I) concentrations and erythropoietic activities in relation to body iron status.	Iron	157-161	insulin like growth factor 1	Homo sapiens	85-90
15487708-3	2004	However, blood hemoglobin and serum iron concentrations averaged 13.4 +/- 0.8 g/dl and 93.7 +/- 41.2 microg/dl in the subjects with IGF-I &gt;809 ng/ml, which were above the values in those with IGF-I &lt;523 ng/ml (12.3 +/- 0.9 g/dl and 50.5 +/- 30.8 microg/dl, p &lt; 0.05, respectively).	Iron	36-40	insulin like growth factor 1	Homo sapiens	132-137
15487708-6	2004	Serum IGF-I correlated significantly with FEP (r = -0.45, p &lt;0.05) and serum iron concentrations (r = 0.40, p &lt;0.05) in iron deficient subjects.	Iron	80-84	insulin like growth factor 1	Homo sapiens	6-11
15487708-6	2004	Serum IGF-I correlated significantly with FEP (r = -0.45, p &lt;0.05) and serum iron concentrations (r = 0.40, p &lt;0.05) in iron deficient subjects.	Iron	126-130	insulin like growth factor 1	Homo sapiens	6-11
15487708-7	2004	In summary, IGF-I seems to have an important relationship to iron metabolism and protoporphyrin synthesis in adolescents.	Iron	61-65	insulin like growth factor 1	Homo sapiens	12-17
15196250-6	2004	Iron also down-regulated NO production and increased the viability of L929 fibrosarcoma cells stimulated with IFN-gamma + LPS in the absence of macrophages.	Iron	0-4	interferon gamma	Mus musculus	110-119
15223010-0	2004	Expression of the SLC11A1 (NRAMP1) 5"-(GT)n repeat: opposite effect in the presence of -237C--&gt;T. Association of various autoimmune and infectious diseases with genetic variation in the solute carrier family 11 member 1 (SLC11A1) gene, formerly known as the natural resistance-associated macrophage protein 1 (NRAMP1) gene, is in accordance with its role in iron metabolism and immune function.	Iron	361-365	solute carrier family 11 member 1	Homo sapiens	18-25
15223010-0	2004	Expression of the SLC11A1 (NRAMP1) 5"-(GT)n repeat: opposite effect in the presence of -237C--&gt;T. Association of various autoimmune and infectious diseases with genetic variation in the solute carrier family 11 member 1 (SLC11A1) gene, formerly known as the natural resistance-associated macrophage protein 1 (NRAMP1) gene, is in accordance with its role in iron metabolism and immune function.	Iron	361-365	solute carrier family 11 member 1	Homo sapiens	27-33
15223010-0	2004	Expression of the SLC11A1 (NRAMP1) 5"-(GT)n repeat: opposite effect in the presence of -237C--&gt;T. Association of various autoimmune and infectious diseases with genetic variation in the solute carrier family 11 member 1 (SLC11A1) gene, formerly known as the natural resistance-associated macrophage protein 1 (NRAMP1) gene, is in accordance with its role in iron metabolism and immune function.	Iron	361-365	solute carrier family 11 member 1	Homo sapiens	189-222
15223010-1	2004	In this investigation, in vitro studies were performed to determine whether allelic variants in the promoter region of the gene are affected by iron loading, thereby leading to differential expression of SLC11A1.	Iron	144-148	solute carrier family 11 member 1	Homo sapiens	204-211
15223010-4	2004	Striking differences were obtained upon iron loading, with allele 3 showing opposite effects in the presence or absence of promoter polymorphism -237C--&gt;T. Our findings provide direct evidence that this promoter polymorphism is functional and support the hypothesis that iron dysregulation mediated by allelic effects of SLC11A1 underlies disease susceptibility linked to infectious and autoimmune conditions.	Iron	40-44	solute carrier family 11 member 1	Homo sapiens	324-331
15223010-4	2004	Striking differences were obtained upon iron loading, with allele 3 showing opposite effects in the presence or absence of promoter polymorphism -237C--&gt;T. Our findings provide direct evidence that this promoter polymorphism is functional and support the hypothesis that iron dysregulation mediated by allelic effects of SLC11A1 underlies disease susceptibility linked to infectious and autoimmune conditions.	Iron	274-278	solute carrier family 11 member 1	Homo sapiens	324-331
15389291-3	2004	We have also studied the regulation of an iron exporter, ferroportin-1 (FPN-1), as an adaptive response mechanism to increased iron levels.	Iron	42-46	solute carrier family 40 member 1	Rattus norvegicus	57-70
15389291-3	2004	We have also studied the regulation of an iron exporter, ferroportin-1 (FPN-1), as an adaptive response mechanism to increased iron levels.	Iron	42-46	solute carrier family 40 member 1	Rattus norvegicus	72-77
15389291-3	2004	We have also studied the regulation of an iron exporter, ferroportin-1 (FPN-1), as an adaptive response mechanism to increased iron levels.	Iron	127-131	solute carrier family 40 member 1	Rattus norvegicus	57-70
15389291-3	2004	We have also studied the regulation of an iron exporter, ferroportin-1 (FPN-1), as an adaptive response mechanism to increased iron levels.	Iron	127-131	solute carrier family 40 member 1	Rattus norvegicus	72-77
15222997-0	2004	Dopamine and iron in the pathophysiology of restless legs syndrome (RLS).	Iron	13-17	RLS1	Homo sapiens	68-71
15193991-0	2004	Increased serum iron may contribute to enhanced oxidation of low-density lipoprotein in smokers in part through changes in lipoxygenase and catalase.	Iron	16-20	catalase	Homo sapiens	140-148
15193991-9	2004	Moreover, iron loading decreased catalase expression by 50% and significantly reduced its activity by 75%.	Iron	10-14	catalase	Homo sapiens	33-41
15193991-11	2004	Iron-induced modulation of expression and activity of 12-LO and catalase may be relevant to increased iron-related oxidative stress as observed in smokers.	Iron	0-4	catalase	Homo sapiens	64-72
15193991-11	2004	Iron-induced modulation of expression and activity of 12-LO and catalase may be relevant to increased iron-related oxidative stress as observed in smokers.	Iron	102-106	catalase	Homo sapiens	64-72
15207835-5	2004	Cp permits the incorporation of iron into transferrin (Trf).	Iron	32-36	transferrin	Homo sapiens	42-53
15207835-5	2004	Cp permits the incorporation of iron into transferrin (Trf).	Iron	32-36	transferrin	Homo sapiens	55-58
15207835-6	2004	Trf inhibits iron ion-dependent OHo formation from H2O2.	Iron	13-17	transferrin	Homo sapiens	0-3
15297761-1	2004	Lactoferrin (Lf), a member of the transferrin family protein, is an iron-binding protein that is known to interact with mammalian cells through a specific receptor.	Iron	68-72	serotransferrin	Bos taurus	34-45
15193975-5	2004	The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism.	Iron	173-177	haptoglobin	Homo sapiens	48-59
15193975-5	2004	The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism.	Iron	173-177	haptoglobin	Homo sapiens	158-169
15193975-5	2004	The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism.	Iron	229-233	haptoglobin	Homo sapiens	48-59
15193975-5	2004	The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism.	Iron	229-233	haptoglobin	Homo sapiens	158-169
15274013-1	2004	Capillary zone electrophoresis (CZE) with a dynamic double coating formed by charged polymeric reagents represents an effective tool for the separation of iron-saturated transferrin (Tf) isoforms and thus the determination of carbohydrate-deficient transferrin (CDT, sum of asialo-, monosialo- and disialo-Tf in relation to total Tf) in human serum.	Iron	155-159	transferrin	Homo sapiens	170-181
15265007-0	2004	Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ.	Iron	52-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
15265007-6	2004	Micro X-ray imaging analysis revealed that the iron content in Nrf2-deficient mouse incisors were significantly decreased compared to that of wild-type mice.	Iron	47-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
15265007-7	2004	We found that iron was aberrantly deposited in the papillary layer cells of enamel organ in Nrf2-deficient mouse, suggesting that the iron transport from blood vessels to ameloblasts was disturbed.	Iron	14-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
15265007-7	2004	We found that iron was aberrantly deposited in the papillary layer cells of enamel organ in Nrf2-deficient mouse, suggesting that the iron transport from blood vessels to ameloblasts was disturbed.	Iron	134-138	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
15265007-8	2004	We also found that ameloblasts of Nrf2-null mouse show degenerative atrophy at the late maturation stage, which gives rise to the loss of iron deposition to the surface of mature enamel.	Iron	138-142	nuclear factor, erythroid derived 2, like 2	Mus musculus	34-38
15265007-9	2004	Our results thus demonstrate that the enamel organ of Nrf2-deficient mouse has a reduced iron transport capacity, which results in both the enamel cell degeneration and disturbance of iron deposition on to the enamel surface.	Iron	89-93	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
15265007-9	2004	Our results thus demonstrate that the enamel organ of Nrf2-deficient mouse has a reduced iron transport capacity, which results in both the enamel cell degeneration and disturbance of iron deposition on to the enamel surface.	Iron	184-188	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
15215767-9	2004	After controlling for other factors, HIV-infected participants with CD4(+) T cells &gt;/=500 had decreased iron intake (P&lt;.05) and tended to be associated with lower intakes of vitamins C and E (P&lt;.10) compared with those with more advanced disease and HIV-uninfected youths.	Iron	107-111	CD4 molecule	Homo sapiens	68-71
15222997-9	2004	CONCLUSIONS: It is concluded that there may be an iron-dopamine connection central to the pathophysiology of RLS for at least some if not most patients with this disorder.	Iron	50-54	RLS1	Homo sapiens	109-112
15184673-9	2004	Our results imply that AtNAP7 represents a conserved SufC protein involved in the biogenesis and/or repair of oxidatively damaged Fe-S clusters and suggest an important role for plastidic Fe-S cluster maintenance and repair during Arabidopsis embryogenesis.	Iron	130-134	non-intrinsic ABC protein 7	Arabidopsis thaliana	23-29
15205699-4	2004	Radioiodinated transferrin saturated with iron [(125)I-Tf(Fe)(2)] was used as tracer.	Iron	42-46	transferrin	Homo sapiens	15-26
15227727-5	2004	Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD.	Iron	0-4	superoxide dismutase 1	Rattus norvegicus	157-167
15184673-9	2004	Our results imply that AtNAP7 represents a conserved SufC protein involved in the biogenesis and/or repair of oxidatively damaged Fe-S clusters and suggest an important role for plastidic Fe-S cluster maintenance and repair during Arabidopsis embryogenesis.	Iron	188-192	non-intrinsic ABC protein 7	Arabidopsis thaliana	23-29
15044462-4	2004	We demonstrate that this is not due to an effect on the transferrin (TF)-mediated iron uptake pathway but rather due to inhibition of iron efflux from the cell.	Iron	82-86	transferrin	Homo sapiens	69-71
15172111-0	2004	Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis.	Iron	31-35	interleukin 1 beta	Rattus norvegicus	0-17
15044462-8	2004	This is a distinct role from that in HeLa and human embryonic kidney 293 cells where HFE has been shown to inhibit TF-mediated iron uptake resulting in decreased ferritin levels.	Iron	127-131	transferrin	Homo sapiens	115-117
15056661-1	2004	Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis.	Iron	87-91	transferrin	Homo sapiens	110-121
15172111-0	2004	Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis.	Iron	31-35	solute carrier family 40 member 1	Rattus norvegicus	106-119
15172111-3	2004	The iron exporter ferroportin-1 (FP) and the multicopper oxidase ceruloplasmin (CP) are essential for iron efflux from cells.	Iron	4-8	solute carrier family 40 member 1	Rattus norvegicus	18-31
15172111-3	2004	The iron exporter ferroportin-1 (FP) and the multicopper oxidase ceruloplasmin (CP) are essential for iron efflux from cells.	Iron	4-8	solute carrier family 40 member 1	Rattus norvegicus	33-35
15172111-3	2004	The iron exporter ferroportin-1 (FP) and the multicopper oxidase ceruloplasmin (CP) are essential for iron efflux from cells.	Iron	102-106	solute carrier family 40 member 1	Rattus norvegicus	18-31
15172111-3	2004	The iron exporter ferroportin-1 (FP) and the multicopper oxidase ceruloplasmin (CP) are essential for iron efflux from cells.	Iron	102-106	solute carrier family 40 member 1	Rattus norvegicus	33-35
15172111-6	2004	Moreover, IL-1beta has been found to increase iron efflux from C6 cells, suggesting that both proteins may play a crucial role in iron homeostasis in pathological brain conditions, such as inflammatory and/or neurodegenerative diseases.	Iron	46-50	interleukin 1 alpha	Rattus norvegicus	10-18
15172111-6	2004	Moreover, IL-1beta has been found to increase iron efflux from C6 cells, suggesting that both proteins may play a crucial role in iron homeostasis in pathological brain conditions, such as inflammatory and/or neurodegenerative diseases.	Iron	130-134	interleukin 1 alpha	Rattus norvegicus	10-18
15067523-0	2004	The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-beta-lactamase family.	Iron	15-19	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	32-45
15194543-1	2004	We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients.	Iron	117-121	erythropoietin	Homo sapiens	57-71
15135642-0	2004	Mutational biases associated with potential iron-binding DNA motifs in rodent lacI and human p53 mutational databases.	Iron	44-48	tumor protein p53	Homo sapiens	93-96
15163319-0	2004	In patients who have stainable iron in the bone marrow an elevated plasma transferrin receptor value may reflect functional iron deficiency.	Iron	31-35	transferrin	Homo sapiens	74-85
15153577-0	2004	Non-transferrin-bound iron in the serum of hemodialysis patients who receive ferric saccharate: no correlation to peroxide generation.	Iron	22-26	transferrin	Homo sapiens	4-15
15153577-1	2004	Intravenous iron (iv.Fe) is used to optimize response to recombinant human erythropoietin (r-HuEPO) in ESRD, but no consensus exists with respect to the best regimen to avoid transferrin "oversaturation," oxidative stress, and the occurrence of non-transferrin-bound iron (NTBI).	Iron	12-16	erythropoietin	Homo sapiens	75-89
15153577-1	2004	Intravenous iron (iv.Fe) is used to optimize response to recombinant human erythropoietin (r-HuEPO) in ESRD, but no consensus exists with respect to the best regimen to avoid transferrin "oversaturation," oxidative stress, and the occurrence of non-transferrin-bound iron (NTBI).	Iron	12-16	transferrin	Homo sapiens	175-186
15153577-1	2004	Intravenous iron (iv.Fe) is used to optimize response to recombinant human erythropoietin (r-HuEPO) in ESRD, but no consensus exists with respect to the best regimen to avoid transferrin "oversaturation," oxidative stress, and the occurrence of non-transferrin-bound iron (NTBI).	Iron	12-16	transferrin	Homo sapiens	249-260
15153577-1	2004	Intravenous iron (iv.Fe) is used to optimize response to recombinant human erythropoietin (r-HuEPO) in ESRD, but no consensus exists with respect to the best regimen to avoid transferrin "oversaturation," oxidative stress, and the occurrence of non-transferrin-bound iron (NTBI).	Iron	21-23	erythropoietin	Homo sapiens	75-89
15067523-1	2004	Cytosolic glyoxalase 2 (GLX2-2) from Arabidopsis thaliana is a metalloenzyme that has been shown to bind a mixture of Zn, Fe, or Mn when produced in cells grown in rich media.	Iron	122-124	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	24-30
15067523-2	2004	In an effort to prepare metal-enriched samples, GLX2-2 was over-expressed in minimal media containing either Zn, Fe, or Mn.	Iron	113-115	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	48-54
15067523-7	2004	EXAFS spectra on the minimal media GLX2-2 samples over-expressed in the presence of Fe or Zn were also very similar to those of the rich media GLX2-2 samples, indicating the presence of dinuclear metal centers.	Iron	84-86	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	35-41
15149323-9	2004	RESULTS: Iron alone or sepsis alone each induced oxidant stress in heart and kidney (HO-1 mRNA/protein increases).	Iron	9-13	heme oxygenase 1	Mus musculus	85-89
15175035-0	2004	Ultraviolet a radiation-induced immediate iron release is a key modulator of the activation of NF-kappaB in human skin fibroblasts.	Iron	42-46	nuclear factor kappa B subunit 1	Homo sapiens	95-104
15175035-3	2004	We report here that in skin fibroblasts, the extent of NF-kappaB activation by UVA tightly correlates with the level of "UVA-induced" labile iron release as shown by both iron chelation and iron loading treatments.	Iron	141-145	nuclear factor kappa B subunit 1	Homo sapiens	55-64
15175035-3	2004	We report here that in skin fibroblasts, the extent of NF-kappaB activation by UVA tightly correlates with the level of "UVA-induced" labile iron release as shown by both iron chelation and iron loading treatments.	Iron	171-175	nuclear factor kappa B subunit 1	Homo sapiens	55-64
15175035-3	2004	We report here that in skin fibroblasts, the extent of NF-kappaB activation by UVA tightly correlates with the level of "UVA-induced" labile iron release as shown by both iron chelation and iron loading treatments.	Iron	171-175	nuclear factor kappa B subunit 1	Homo sapiens	55-64
15175035-4	2004	Furthermore, our data indicate that the slow kinetics of induction of NF-kappaB by UVA relative to other oxidants previously studied is due to a transient increase in permeability of nuclear membrane to proteins and occurs as a result of labile iron-mediated damage to nuclear membrane.	Iron	245-249	nuclear factor kappa B subunit 1	Homo sapiens	70-79
15175035-5	2004	Since in addition to iron chelators, lipid peroxidation inhibitors also decrease the UVA-mediated induction of NF-kappaB, we propose that the rapid release of labile iron by UVA might act as a catalyst to exacerbate the generation of lipid secondary messengers in skin cell membranes that are responsible for induction of NF-kappaB.	Iron	166-170	nuclear factor kappa B subunit 1	Homo sapiens	111-120
15175035-5	2004	Since in addition to iron chelators, lipid peroxidation inhibitors also decrease the UVA-mediated induction of NF-kappaB, we propose that the rapid release of labile iron by UVA might act as a catalyst to exacerbate the generation of lipid secondary messengers in skin cell membranes that are responsible for induction of NF-kappaB.	Iron	166-170	nuclear factor kappa B subunit 1	Homo sapiens	322-331
15175035-6	2004	This novel role for iron in amplifying NF-kappaB mobilization in response to UVA-induced oxidative stress aids understanding of its involvement in UV-induced skin inflammation.	Iron	20-24	nuclear factor kappa B subunit 1	Homo sapiens	39-48
15172062-6	2004	The T(1) and T(2) relaxivities of transferrin iron were 2.40 and 2.60 mM(-1)s(-1), respectively.	Iron	46-50	transferrin	Homo sapiens	34-45
15149323-10	2004	When iron and E. coli were coadministered, additive or synergistic HO-1 mRNA/protein increments resulted.	Iron	5-9	heme oxygenase 1	Mus musculus	67-71
15149323-11	2004	Iron injection alone only slightly raised TNF-alpha levels (from 0 to 2.3 pg/mL; P= 0.01).	Iron	0-4	tumor necrosis factor	Mus musculus	42-51
15149323-12	2004	However, iron approximately doubled the TNF-alpha increments which arose from the septic state (1400 --&gt; 2600 pg/mL).	Iron	9-13	tumor necrosis factor	Mus musculus	40-49
15149323-15	2004	CONCLUSION: Parenteral iron administration can induce systemic oxidative stress and modest TNF-alpha release.	Iron	23-27	tumor necrosis factor	Mus musculus	91-100
15184553-4	2004	Growth of an fpvA mutant of P. aeruginosa PAO1 (type I) under iron-limiting conditions can still be stimulated by its cognate pyoverdine, suggesting the presence of an alternative uptake route for type I ferripyoverdine.	Iron	62-66	ferripyoverdine receptor	Pseudomonas aeruginosa PAO1	13-17
15143178-10	2004	Further, the bacterial homologue IscU and the human Isu proteins (partially) complemented the defects of yeast Isu protein-depleted cells in growth rate, Fe/S protein biogenesis, and iron homeostasis, yet only after targeting to mitochondria.	Iron	183-187	iron-sulfur cluster assembly enzyme	Homo sapiens	33-37
15214509-3	2004	In the case of transferrin, this would indirectly also influence iron homeostasis.	Iron	65-69	transferrin	Homo sapiens	15-26
15214510-3	2004	Theoretically transferrin should prohibit iron from participating in oxidative reactions, but transferrin has also been found to promote free radical damage.	Iron	42-46	transferrin	Homo sapiens	14-25
15052462-3	2004	In this meta-analysis we sought to combine evidence by pooling clinical trial data to determine if i.v.Fe therapy helped increase hematocrit, serum levels of hemoglobin, ferritin, and transferrin saturation (TSAT), and reduce erythropoietin use.	Iron	103-105	transferrin	Homo sapiens	184-195
15004263-0	2004	Low-dose continuous iron therapy leads to a positive iron balance and decreased serum transferrin levels in chronic haemodialysis patients.	Iron	20-24	transferrin	Homo sapiens	86-97
15004263-2	2004	Continuous maintenance therapy with iron has been proposed for dialysis patients on recombinant human erythropoietin (rHuEpo) in the hope that the regimen is adequate and safe.	Iron	36-40	erythropoietin	Homo sapiens	102-116
15052462-3	2004	In this meta-analysis we sought to combine evidence by pooling clinical trial data to determine if i.v.Fe therapy helped increase hematocrit, serum levels of hemoglobin, ferritin, and transferrin saturation (TSAT), and reduce erythropoietin use.	Iron	103-105	erythropoietin	Homo sapiens	226-240
15064942-1	2004	Iron therapy maintains iron stores and optimizes the response to recombinant human erythropoietin (r-HuEPO) in patients with end-stage renal failure.	Iron	0-4	erythropoietin	Homo sapiens	83-97
15158359-2	2004	Previous studies showed that NO can inhibit Fe uptake from transferrin (Tf) and increase Fe mobilisation from cells [J. Biol.	Iron	44-46	transferrin	Homo sapiens	59-70
15153529-0	2004	Iron chelator triggers inflammatory signals in human intestinal epithelial cells: involvement of p38 and extracellular signal-regulated kinase signaling pathways.	Iron	0-4	mitogen-activated protein kinase 14	Homo sapiens	97-100
15123426-14	2004	In addition, the phosphorylation of STAT3 induced by G-CSF was decreased in iron chelator-treated hematopoietic cells.	Iron	76-80	signal transducer and activator of transcription 3	Homo sapiens	36-41
15147208-5	2004	The proximal pocket of leghemoglobin is designed to favor strong coordination bonds between the heme iron and axial ligands.	Iron	101-105	leghemoglobin A	Glycine max	23-36
15140607-0	2004	Thy1 expression in the brain is affected by iron and is decreased in Restless Legs Syndrome.	Iron	44-48	Thy-1 cell surface antigen	Rattus norvegicus	0-4
15103330-5	2004	Assembly of its Fe/S clusters crucially depends on components of the mitochondrial Fe/S cluster biosynthesis apparatus such as the cysteine desulphurase Nfs1p, the ferredoxin Yah1p and the ABC transporter Atm1p.	Iron	16-18	cysteine desulfurase	Saccharomyces cerevisiae S288C	153-158
15103330-5	2004	Assembly of its Fe/S clusters crucially depends on components of the mitochondrial Fe/S cluster biosynthesis apparatus such as the cysteine desulphurase Nfs1p, the ferredoxin Yah1p and the ABC transporter Atm1p.	Iron	83-85	cysteine desulfurase	Saccharomyces cerevisiae S288C	153-158
15123433-0	2004	The oxalate effect on release of iron from human serum transferrin explained.	Iron	33-37	transferrin	Homo sapiens	55-66
15123433-1	2004	A unique feature of the mechanism of iron binding to the transferrin (TF) family is the synergistic relationship between metal binding and anion binding.	Iron	37-41	transferrin	Homo sapiens	57-68
15123433-1	2004	A unique feature of the mechanism of iron binding to the transferrin (TF) family is the synergistic relationship between metal binding and anion binding.	Iron	37-41	transferrin	Homo sapiens	70-72
15114622-2	2004	DMT1 +IRE species (encoded by mRNA with an iron-responsive element) are limited to the plasma membrane and cytosolic vesicles.	Iron	43-47	solute carrier family 11 member 2	Rattus norvegicus	0-4
15140607-2	2004	The objective of this study is to examine the relationship between iron status and Thy1 expression in neuronal systems of varying complexity.	Iron	67-71	Thy-1 cell surface antigen	Rattus norvegicus	83-87
15140607-3	2004	Pheochromocytoma cell (PC12) cells were used to explore whether there was a direct relation between cellular iron status and Thy1 expression.	Iron	109-113	Thy-1 cell surface antigen	Rattus norvegicus	125-129
15140607-4	2004	Iron chelation significantly decreased expression of Thy1 in PC12 cells in a dose and time dependent manner.	Iron	0-4	Thy-1 cell surface antigen	Rattus norvegicus	53-57
15140607-6	2004	We also examined brain homogenates from adult rats that were nursed by dams on an iron deficient (ID) diet and found a significant decrease in Thy1 compared to control rats.	Iron	82-86	Thy-1 cell surface antigen	Rattus norvegicus	143-147
15140607-9	2004	The results of these studies support the novel concept that there is a relationship between Thy1 and iron and point to a novel mechanism by which iron deficiency can affect brain function.	Iron	101-105	Thy-1 cell surface antigen	Rattus norvegicus	92-96
15124177-7	2004	Caspase-3 activity, an indicator of cell apoptosis, considerably increased in preconfluent cells at high iron levels compared to the control (p &lt; 0.05), whereas postconfluent cells were not significantly affected.	Iron	105-109	caspase 3	Homo sapiens	0-9
14993221-0	2004	Iron-sulfur cluster assembly: NifU-directed activation of the nitrogenase Fe protein.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	30-34
14993228-4	2004	In contrast, a screen of high-copy number plasmid libraries for clones able to increase tolerance to alkaline pH revealed only two genes: FET4 (encoding a low affinity transporter for copper, iron, and zinc) and CTR1 (encoding a high affinity copper transporter).	Iron	192-196	Fet4p	Saccharomyces cerevisiae S288C	138-142
15114602-1	2004	Parenteral iron therapy is occasionally necessary for patients intolerant or unresponsive to oral iron therapy, for receiving recombinant erythropoietin therapy, or for use in treating functional iron deficiency.	Iron	11-15	erythropoietin	Homo sapiens	138-152
15111596-8	2004	CONCLUSIONS: Increased mRNA and protein levels of the iron-regulating proteins transferrin, ceruloplasmin, and ferritin are present in glaucoma.	Iron	54-58	transferrin	Homo sapiens	79-90
15128303-1	2004	The divalent metal transporter (DMT1) is a 12-transmembrane domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	99-103	transferrin	Homo sapiens	153-164
15128303-1	2004	The divalent metal transporter (DMT1) is a 12-transmembrane domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	131-135	transferrin	Homo sapiens	153-164
15129378-2	2004	This study examined whether adults with elevated iron, as measured by transferrin saturation (TS), and elevated LDL are at an increased risk for mortality.	Iron	49-53	transferrin	Homo sapiens	70-81
15082582-4	2004	RESULTS: Decreased hepatic non-haem iron and transferrin saturation and increased expression of transferrin receptor 1 in the liver indicated a progressive reduction in maternal body iron stores during pregnancy.	Iron	183-187	transferrin	Rattus norvegicus	96-107
14752097-5	2004	MPP(+) caused a time-dependent depletion of tetrahydrobiopterin (BH(4)) that was mediated by H(2)O(2) and transferrin iron.	Iron	118-122	transferrin	Homo sapiens	106-117
15162891-8	2004	Assays were performed for both total iron and transferrin-bound iron, from which drug-bound iron could be calculated.	Iron	64-68	transferrin	Homo sapiens	46-57
15162891-8	2004	Assays were performed for both total iron and transferrin-bound iron, from which drug-bound iron could be calculated.	Iron	64-68	transferrin	Homo sapiens	46-57
15162891-13	2004	Serum iron from SFGC became rapidly available (&lt; 24 hrs) as transferrin-bound iron, but only after passage through another compartment, presumably the reticuloendothelial system (RES).	Iron	6-10	transferrin	Homo sapiens	63-74
15162891-13	2004	Serum iron from SFGC became rapidly available (&lt; 24 hrs) as transferrin-bound iron, but only after passage through another compartment, presumably the reticuloendothelial system (RES).	Iron	81-85	transferrin	Homo sapiens	63-74
15162891-15	2004	CONCLUSIONS: Iron derived from SFGC appears to be rapidly transferred to a bioavailable iron compartment as transferrin-bound iron after digestion in the RES.	Iron	13-17	transferrin	Homo sapiens	108-119
15162891-15	2004	CONCLUSIONS: Iron derived from SFGC appears to be rapidly transferred to a bioavailable iron compartment as transferrin-bound iron after digestion in the RES.	Iron	88-92	transferrin	Homo sapiens	108-119
15162891-15	2004	CONCLUSIONS: Iron derived from SFGC appears to be rapidly transferred to a bioavailable iron compartment as transferrin-bound iron after digestion in the RES.	Iron	126-130	transferrin	Homo sapiens	108-119
15160979-1	2004	Elevated body iron stores (serum ferritin &gt;300 microg/L, transferrin saturation TS &gt;50%) are associated with increased risk of liver and lung cancers.	Iron	14-18	transferrin	Homo sapiens	60-71
15165135-9	2004	Compounds 1 and 2 selectively inhibited hypoxia-activated HIF-1 in contrast to iron chelator-activated HIF-1.	Iron	79-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-108
15086920-6	2004	Iron administration significantly raised the blood hemoglobin, serum iron concentration, and transferrin saturation in both CRF and control groups.	Iron	0-4	transferrin	Rattus norvegicus	93-104
15086920-12	2004	Previous iron administration significantly lowered superoxide dismutase and catalase abundance in the aorta and glutathione peroxidase in the left ventricle of CRF animals, but did not significantly change these parameters in the iron-treated control animals.	Iron	9-13	catalase	Rattus norvegicus	76-84
15179052-7	2004	Taken together, these data suggest that intracellular iron promotes NGF-stimulated differentiation of PC12 cells by increasing ERK activity.	Iron	54-58	Eph receptor B1	Rattus norvegicus	127-130
15111112-1	2004	Transferrin binding protein A (TbpA) is a TonB-dependent outer membrane protein expressed by pathogenic bacteria for iron acquisition from human transferrin.	Iron	117-121	transferrin	Homo sapiens	145-156
14720122-2	2004	At least six proteins (IscS, IscU, IscA, HscB, HscA and ferredoxin) have been identified as being essential for the biogenesis of iron-sulphur proteins in bacteria.	Iron	130-134	iron-sulfur cluster assembly enzyme	Homo sapiens	29-33
14720122-3	2004	It has been shown that IscS is a cysteine desulphurase that provides sulphur for iron-sulphur clusters, and that IscU is a scaffold for the IscS-mediated assembly of iron-sulphur clusters.	Iron	166-170	iron-sulfur cluster assembly enzyme	Homo sapiens	113-117
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	29-33	iron-sulfur cluster assembly enzyme	Homo sapiens	212-216
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	212-216
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	212-216
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	212-216
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	iron-sulfur cluster assembly enzyme	Homo sapiens	212-216
15081272-8	2004	The simultaneous addition of iron in either ferric or ferrous form and nickel completely inhibited IL-8 production and had no effect on "hypoxia-like" stress caused by nickel, suggesting the existence of two different pathways for the induction "hypoxia-like" stress and IL-8 production.	Iron	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
15044101-0	2004	Tertiary structural changes associated with iron binding and release in hen serum transferrin: a crystallographic and spectroscopic study.	Iron	44-48	transferrin	Homo sapiens	82-93
15044101-1	2004	The iron binding and release of serum transferrin are pH-dependent and accompanied by a conformational change between the iron-bound (holo-) and iron-free (apo-) forms.	Iron	4-8	transferrin	Homo sapiens	38-49
15044101-1	2004	The iron binding and release of serum transferrin are pH-dependent and accompanied by a conformational change between the iron-bound (holo-) and iron-free (apo-) forms.	Iron	122-126	transferrin	Homo sapiens	38-49
15044101-1	2004	The iron binding and release of serum transferrin are pH-dependent and accompanied by a conformational change between the iron-bound (holo-) and iron-free (apo-) forms.	Iron	122-126	transferrin	Homo sapiens	38-49
15044101-2	2004	We have determined the crystal structure of apo-hen serum transferrin (hAST) at 3.5A resolution, which is the first reported structure to date of any full molecule of an apo-serum transferrin and studied its pH-dependent iron release by UV-vis absorption and near UV-CD spectroscopy.	Iron	221-225	transferrin	Homo sapiens	58-69
15044101-2	2004	We have determined the crystal structure of apo-hen serum transferrin (hAST) at 3.5A resolution, which is the first reported structure to date of any full molecule of an apo-serum transferrin and studied its pH-dependent iron release by UV-vis absorption and near UV-CD spectroscopy.	Iron	221-225	solute carrier family 17 member 5	Homo sapiens	71-75
15044101-4	2004	Spectroscopic analysis reveals that in hen serum transferrin, release of the first iron starts at a pH approximately 6.5 and continues over a broad pH range (6.5-5.2).	Iron	83-87	transferrin	Homo sapiens	49-60
15003320-9	2004	TGF-beta1 showed a negative correlation with serum glutathione peroxidase (GPx) activity (r = -0.674, P &lt; 0.003), but a positive correlation with the serum iron level (r = 0.836, P &lt; 0.0001).	Iron	159-163	transforming growth factor, beta 1	Rattus norvegicus	0-9
15081272-8	2004	The simultaneous addition of iron in either ferric or ferrous form and nickel completely inhibited IL-8 production and had no effect on "hypoxia-like" stress caused by nickel, suggesting the existence of two different pathways for the induction "hypoxia-like" stress and IL-8 production.	Iron	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
15096062-3	2004	The model complexes mimic almost all the intrinsic properties of the unique M(III) (M = Fe, Co) active site of NHase.	Iron	88-90	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	78-81
15042544-7	2004	Multivariate Poisson and Cox models adjusted for demographic features, dialysis dose and vintage, serum albumin and ferritin and blood hemoglobin concentrations, and administered EPO and iron doses showed that both serum iron level and iron saturation ratio had significant, but inverse, associations with prospective mortality and hospitalization.	Iron	221-225	erythropoietin	Homo sapiens	179-182
15053923-0	2004	Increased GADD153 gene expression during iron chelation-induced apoptosis in Jurkat T-lymphocytes.	Iron	41-45	DNA damage inducible transcript 3	Homo sapiens	10-17
15042544-7	2004	Multivariate Poisson and Cox models adjusted for demographic features, dialysis dose and vintage, serum albumin and ferritin and blood hemoglobin concentrations, and administered EPO and iron doses showed that both serum iron level and iron saturation ratio had significant, but inverse, associations with prospective mortality and hospitalization.	Iron	221-225	erythropoietin	Homo sapiens	179-182
15042544-10	2004	CONCLUSION: Low baseline serum iron indicators are associated with increased mortality and hospitalization in MHD patients independent of hemoglobin level, EPO and iron doses, indicators of nutrition and inflammation, and comorbid conditions.	Iron	31-35	erythropoietin	Homo sapiens	156-159
15078340-6	2004	Changes in mucosal Divalent Metal Transporter 1 (DMT-1), Dcytb and Ireg1 (iron regulated protein 1) mRNA levels paralleled the changes in iron absorption.	Iron	74-78	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	67-72
15053923-10	2004	Because GADD153 is recognized as a pro-apoptotic gene, these findings generate the notion that GADD153 might help mediate apoptosis in iron-deficient cells.	Iron	135-139	DNA damage inducible transcript 3	Homo sapiens	8-15
15053923-10	2004	Because GADD153 is recognized as a pro-apoptotic gene, these findings generate the notion that GADD153 might help mediate apoptosis in iron-deficient cells.	Iron	135-139	DNA damage inducible transcript 3	Homo sapiens	95-102
15084469-0	2004	Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice.	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	14-27
15088936-2	2004	Human transferrin, normally about 30% saturated with iron in vivo, has two sites/molecule capable of complexing Cu(II); one more strongly than the other (Hirose et al.	Iron	53-57	transferrin	Homo sapiens	6-17
15088936-6	2004	In vivo the albumin concentration is considerably higher than that of iron-free transferrin, and it seems unlikely that the latter can compete with albumin for non-ceruloplasmin cupric ions.	Iron	70-74	transferrin	Homo sapiens	80-91
15071397-14	2004	These effects were accompanied by a pronounced expression of CD11b in polymorphonuclear leukocytes and tissue sequestration of blood iron-transferrin complexes during the entire 24-hr period of observations.	Iron	133-137	transferrin	Rattus norvegicus	138-149
15071397-15	2004	The increase in circulatory polymorphonuclear leukocytes was accompanied by a decrease in iron-transferrin complex concentrations that apparently reflected implication of blood plasma iron in the inflammatory cell response to OPW-induced injury.	Iron	90-94	transferrin	Rattus norvegicus	95-106
15071397-18	2004	The data further suggest that the expression of polymorphonuclear leukocyte CD11b and the response of iron-transferrin complex can be considered as potential surrogate markers in blood for systemic alterations following OPW-induced injury and, therefore, warrant further investigation in a human pilot study.	Iron	102-106	transferrin	Rattus norvegicus	107-118
15084469-3	2004	A 58 bp microdeletion in the Fpn1 promoter region alters transcription start sites and eliminates the iron responsive element (IRE) in the 5" untranslated region, resulting in increased duodenal and hepatic Fpn1 protein levels during early postnatal development.	Iron	102-106	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	29-33
15084469-4	2004	Pcm mutants, which are iron deficient at birth, exhibited increased Fpn1-mediated iron uptake and reticuloendothelial iron overload as young adult mice.	Iron	23-27	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-3
15084469-4	2004	Pcm mutants, which are iron deficient at birth, exhibited increased Fpn1-mediated iron uptake and reticuloendothelial iron overload as young adult mice.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-3
15084469-4	2004	Pcm mutants, which are iron deficient at birth, exhibited increased Fpn1-mediated iron uptake and reticuloendothelial iron overload as young adult mice.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	68-72
15084469-4	2004	Pcm mutants, which are iron deficient at birth, exhibited increased Fpn1-mediated iron uptake and reticuloendothelial iron overload as young adult mice.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-3
15084469-4	2004	Pcm mutants, which are iron deficient at birth, exhibited increased Fpn1-mediated iron uptake and reticuloendothelial iron overload as young adult mice.	Iron	82-86	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	68-72
15084469-7	2004	Delayed upregulation of the negative hormonal regulator of iron homeostasis, hepcidin (Hamp), during postnatal development correlates strongly with profound increases in Fpn1 protein levels and polycythemia in Pcm heterozygotes.	Iron	59-63	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	170-174
15084469-7	2004	Delayed upregulation of the negative hormonal regulator of iron homeostasis, hepcidin (Hamp), during postnatal development correlates strongly with profound increases in Fpn1 protein levels and polycythemia in Pcm heterozygotes.	Iron	59-63	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	210-213
15084469-8	2004	Thus, our data suggest that a Hamp-mediated regulatory interference alleviates the defects in iron homeostasis and transient alterations in erythropoiesis caused by a regulatory mutation in Fpn1.	Iron	94-98	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	190-194
15203893-12	2004	Finally, following iron scavenging by deferoxamine mesylate (DFO, resulting in a higher Tf R expression) a 5-fold increase in association of Tf-HRP to 15.8 ng/mg cell protein was observed.	Iron	19-23	serotransferrin	Bos taurus	88-90
15039322-1	2004	We have reported that Mycobacterium tuberculosis residing within the phagosomes of human monocyte-derived macrophages (MDM) can acquire Fe from extracellular transferrin (TF) and sources within the MDM.	Iron	136-138	transferrin	Homo sapiens	158-169
15039322-1	2004	We have reported that Mycobacterium tuberculosis residing within the phagosomes of human monocyte-derived macrophages (MDM) can acquire Fe from extracellular transferrin (TF) and sources within the MDM.	Iron	136-138	transferrin	Homo sapiens	171-173
15051778-0	2004	Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter, open-label, randomized trial.	Iron	12-16	erythropoietin	Homo sapiens	61-75
15203893-12	2004	Finally, following iron scavenging by deferoxamine mesylate (DFO, resulting in a higher Tf R expression) a 5-fold increase in association of Tf-HRP to 15.8 ng/mg cell protein was observed.	Iron	19-23	serotransferrin	Bos taurus	141-143
15057521-1	2004	IRP2 plays an important role in brain iron metabolism.	Iron	38-42	iron responsive element binding protein 2	Homo sapiens	0-4
15030976-5	2004	The iron-induced cell injury was oxygen-dependent, and although it was not inhibitable by extracellular catalase, it was strongly inhibited by the novel membrane-permeable catalase mimic TAA-1/Fe.	Iron	4-8	catalase	Rattus norvegicus	172-180
15030991-2	2004	The phenotype of iron overload in one member of this family is associated with high serum ferritin concentration and elevated transferrin saturation.	Iron	17-21	transferrin	Homo sapiens	126-137
15039637-4	2004	The first involves binding of iron to transferrin and uptake via transferrin receptors.	Iron	30-34	transferrin	Homo sapiens	38-49
15039637-4	2004	The first involves binding of iron to transferrin and uptake via transferrin receptors.	Iron	30-34	transferrin	Homo sapiens	65-76
15039637-7	2004	RESULTS: Proinflammatory cytokines increase transferrin and non-transferrin bound iron uptake into human monocytes and increase transferrin-bound iron uptake by synovial fibroblasts, but have no effect on non-transferrin bound uptake into fibroblasts.	Iron	82-86	transferrin	Homo sapiens	64-75
15039637-7	2004	RESULTS: Proinflammatory cytokines increase transferrin and non-transferrin bound iron uptake into human monocytes and increase transferrin-bound iron uptake by synovial fibroblasts, but have no effect on non-transferrin bound uptake into fibroblasts.	Iron	82-86	transferrin	Homo sapiens	64-75
15039637-7	2004	RESULTS: Proinflammatory cytokines increase transferrin and non-transferrin bound iron uptake into human monocytes and increase transferrin-bound iron uptake by synovial fibroblasts, but have no effect on non-transferrin bound uptake into fibroblasts.	Iron	82-86	transferrin	Homo sapiens	64-75
15084319-1	2004	The geometries and vibrational frequencies of an iron(II) spin-crossover complex Fe(phen)2(NCS)2 in the low- and high-spin states have been calculated using DFT (BP86 functional with 6-311G* + Wachters + f, 6-31G* and LANL2DZ basis sets).	Iron	49-53	cytosolic thiouridylase subunit 2	Homo sapiens	91-96
15060098-10	2004	CONCLUSION: We suggest that the combination of TF C2 and HFE C282Y may lead to an excess of redox-active iron and the induction of oxidative stress in neurones, which is exacerbated in carriers of APOE4.	Iron	105-109	transferrin	Homo sapiens	47-49
15060098-10	2004	CONCLUSION: We suggest that the combination of TF C2 and HFE C282Y may lead to an excess of redox-active iron and the induction of oxidative stress in neurones, which is exacerbated in carriers of APOE4.	Iron	105-109	apolipoprotein E	Homo sapiens	197-202
14722066-3	2004	By contrast, the eukaryotic ortholog of IscS (Nfs1) has thus far been shown to be functional only in mitochondrial iron-sulfur cluster biogenesis.	Iron	115-119	cysteine desulfurase	Saccharomyces cerevisiae S288C	46-50
14973193-0	2004	Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron efflux.	Iron	89-93	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	15-28
14722110-1	2004	The Saccharomyces cerevisiae GRX5 gene codes for a mitochondrial glutaredoxin involved in the synthesis of iron/sulfur clusters.	Iron	107-111	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	29-33
14722110-7	2004	BIO5 is another Aft1-dependent gene induced both upon iron deprivation and in Deltagrx5 cells; this links iron and biotin metabolism.	Iron	54-58	Bio5p	Saccharomyces cerevisiae S288C	0-4
15040387-4	2004	In the infected host iron is bound to proteins such as transferrin and ferritin.	Iron	21-25	transferrin	Homo sapiens	55-66
14972659-2	2004	Transferrin-bound iron enters the endothelial cells of the blood-brain barrier from the systemic circulation, and iron subsequently dissociates from transferrin to enter brain parenchyma by an unknown mechanism.	Iron	18-22	transferrin	Homo sapiens	0-11
14640978-1	2004	Cells take up transferrin-bound iron or NTBI (non-transferrin-bound iron).	Iron	32-36	transferrin	Rattus norvegicus	14-25
14640978-1	2004	Cells take up transferrin-bound iron or NTBI (non-transferrin-bound iron).	Iron	68-72	transferrin	Rattus norvegicus	14-25
14640978-1	2004	Cells take up transferrin-bound iron or NTBI (non-transferrin-bound iron).	Iron	68-72	transferrin	Rattus norvegicus	50-61
14973193-6	2004	Induction of J774 cell FPN1 expression by copper was also associated with a dose-dependent increase in (59)Fe release after erythrophagocytosis of labeled red blood cells.	Iron	107-109	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	23-27
14973193-7	2004	Thus, a previously uncharacterized role for copper in the regulation of macrophage iron recycling is suggested by the induction of FPN1 gene expression and iron efflux by this metal.	Iron	83-87	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	131-135
14973193-2	2004	To examine whether cellular copper status affects expression of the iron exporter ferroportin-1 (FPN1), J774 macrophage cells were exposed to 10-100 microM CuSO(4) for up to 20 h. Copper treatment significantly increased FPN1 mRNA in a dose- and time-dependent manner.	Iron	68-72	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	97-101
14576080-0	2004	Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase.	Iron	22-26	tumor necrosis factor	Mus musculus	44-53
14996579-2	2004	Oxidative stress of lipids induced by iron may play a role in vascular inflammation, as indicated by CRP.	Iron	38-42	C-reactive protein	Homo sapiens	101-104
14576080-5	2004	In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation.	Iron	17-21	tumor necrosis factor	Mus musculus	153-162
14576080-5	2004	In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation.	Iron	219-223	tumor necrosis factor	Mus musculus	153-162
14592944-1	2004	Hepcidin has been implicated as the iron stores regulator: a hepatic signaling molecule that regulates intestinal iron absorption by undefined mechanisms.	Iron	36-40	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
15083853-1	2004	BACKGROUND: A large proportion of US adults have elevated transferrin saturation, an indicator of a predisposition for iron overload.	Iron	119-123	transferrin	Homo sapiens	58-69
14592944-1	2004	Hepcidin has been implicated as the iron stores regulator: a hepatic signaling molecule that regulates intestinal iron absorption by undefined mechanisms.	Iron	114-118	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
14592944-2	2004	The possibility that hepcidin regulates the expression of ferroportin 1 (FPT1), the basolateral iron transporter, was examined in rats after administration of LPS, an iron chelator, or His-tagged recombinant hepcidin (His-rHepc).	Iron	96-100	hepcidin antimicrobial peptide	Rattus norvegicus	21-29
14592944-2	2004	The possibility that hepcidin regulates the expression of ferroportin 1 (FPT1), the basolateral iron transporter, was examined in rats after administration of LPS, an iron chelator, or His-tagged recombinant hepcidin (His-rHepc).	Iron	96-100	solute carrier family 40 member 1	Rattus norvegicus	58-71
14592944-2	2004	The possibility that hepcidin regulates the expression of ferroportin 1 (FPT1), the basolateral iron transporter, was examined in rats after administration of LPS, an iron chelator, or His-tagged recombinant hepcidin (His-rHepc).	Iron	96-100	solute carrier family 40 member 1	Rattus norvegicus	73-77
14592944-4	2004	The iron chelator pyrrolidinedithiocarbamate (PDTC) stimulated hepatic hepcidin without suppressing intestinal FPT1 expression.	Iron	4-8	hepcidin antimicrobial peptide	Rattus norvegicus	71-79
15083854-2	2004	Because ingestion of dietary iron may contribute to iron overload in persons with elevated transferrin saturation, we investigated the relationship between elevated transferrin saturation, ingestion of dietary iron and red meat, and mortality.	Iron	52-56	transferrin	Homo sapiens	91-102
15083854-2	2004	Because ingestion of dietary iron may contribute to iron overload in persons with elevated transferrin saturation, we investigated the relationship between elevated transferrin saturation, ingestion of dietary iron and red meat, and mortality.	Iron	52-56	transferrin	Homo sapiens	91-102
15083854-8	2004	The adjusted survival analysis indicated that persons with elevated transferrin saturation who reported high dietary iron intake had a hazard ratio for death of 2.90 (95% confidence interval [CI], 1.39-6.04) compared with those with normal transferrin saturation levels and reported low dietary iron intake.	Iron	117-121	transferrin	Homo sapiens	68-79
15083854-8	2004	The adjusted survival analysis indicated that persons with elevated transferrin saturation who reported high dietary iron intake had a hazard ratio for death of 2.90 (95% confidence interval [CI], 1.39-6.04) compared with those with normal transferrin saturation levels and reported low dietary iron intake.	Iron	117-121	transferrin	Homo sapiens	240-251
15083854-8	2004	The adjusted survival analysis indicated that persons with elevated transferrin saturation who reported high dietary iron intake had a hazard ratio for death of 2.90 (95% confidence interval [CI], 1.39-6.04) compared with those with normal transferrin saturation levels and reported low dietary iron intake.	Iron	295-299	transferrin	Homo sapiens	68-79
15083854-10	2004	CONCLUSIONS: Ingestion of large quantities of dietary iron and red meat in persons with high transferrin saturation is associated with an increase in mortality.	Iron	54-58	transferrin	Homo sapiens	93-104
15083853-8	2004	Many of the underlying causes of death for persons with serum transferrin saturation levels of more than 55% are common causes of death in the general population, although these persons were more likely to have died of cirrhosis and diabetes, a finding consistent with iron overload.	Iron	269-273	transferrin	Homo sapiens	62-73
15105251-5	2004	The activities of IRP1 and IRP2 are regulated by distinct posttranslational mechanisms in response to cellular iron levels.	Iron	111-115	iron responsive element binding protein 2	Homo sapiens	27-31
15105251-6	2004	Thus, in iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster, which prevents IRE binding, while IRP2 undergoes proteasomal degradation.	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	108-112
15083854-2	2004	Because ingestion of dietary iron may contribute to iron overload in persons with elevated transferrin saturation, we investigated the relationship between elevated transferrin saturation, ingestion of dietary iron and red meat, and mortality.	Iron	29-33	transferrin	Homo sapiens	91-102
15105251-7	2004	IRP1 and IRP2 also respond, albeit differentially, to iron-independent signals, such as hydrogen peroxide, hypoxia, or nitric oxide.	Iron	54-58	iron responsive element binding protein 2	Homo sapiens	9-13
15105252-1	2004	Neurons need iron, which is reflected in their expression of the transferrin receptor.	Iron	13-17	transferrin	Homo sapiens	65-76
15105265-5	2004	However, it is clear that the iron bound to lesion-associated proteins such as amyloid-beta and tau plays only a minor, late role in the disease, with the RNA-associated iron found in the neuronal cytoplasm occurring early and being of paramount importance.	Iron	30-34	amyloid beta precursor protein	Homo sapiens	79-91
15105252-2	2004	The concurrent expression of the ferrous iron transporter, divalent metal transporter I (DMT1), in neurons suggests that the internalization of transferrin is followed by detachment of iron within recycling endosomes and transport into the cytosol via DMT1.	Iron	41-45	transferrin	Homo sapiens	144-155
15105252-4	2004	The presence of nontransferrin-bound iron in brain extracellular fluids suggests that neurons can also take up iron in a transferrin-free form.	Iron	37-41	transferrin	Homo sapiens	19-30
15105252-6	2004	The general lack of ferritin together with the prevailing expression of the transferrin receptor indicates that iron acquired by activity of transferrin receptors is directed toward immediate use in relevant metabolic processes, is exported, or is incorporated into complexes other than ferritin.	Iron	112-116	transferrin	Homo sapiens	76-87
15105252-6	2004	The general lack of ferritin together with the prevailing expression of the transferrin receptor indicates that iron acquired by activity of transferrin receptors is directed toward immediate use in relevant metabolic processes, is exported, or is incorporated into complexes other than ferritin.	Iron	112-116	transferrin	Homo sapiens	141-152
15105271-5	2004	Particular attention will be paid to the role and distribution of iron and proteins involved with iron metabolism (e.g., transferrin, ferritin, heme oxygenase-1, etc.)	Iron	98-102	transferrin	Homo sapiens	121-132
15105252-9	2004	Brain ischemia may also lead to an increase in iron supply to neurons as transferrin receptor expression by brain capillary endothelial cells is increased.	Iron	47-51	transferrin	Homo sapiens	73-84
15105272-14	2004	The defect in PANK2 is predicted to cause the accumulation of cysteine, which binds iron and causes oxidative stress in the iron-rich globus pallidus.	Iron	84-88	pantothenate kinase 2	Homo sapiens	14-19
15105272-14	2004	The defect in PANK2 is predicted to cause the accumulation of cysteine, which binds iron and causes oxidative stress in the iron-rich globus pallidus.	Iron	124-128	pantothenate kinase 2	Homo sapiens	14-19
15105273-5	2004	We demonstrate mitochondrial localization of PANK2 and speculate on mechanisms of secondary iron accumulation in PKAN.	Iron	92-96	pantothenate kinase 2	Homo sapiens	113-117
14972637-0	2004	Iron assessment tests: transferrin receptor vis-a-vis zinc protoporphyrin.	Iron	0-4	transferrin	Homo sapiens	23-34
14989268-1	2004	In this mini-review, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to a variety of oxidative stresses.	Iron	67-71	transferrin	Homo sapiens	37-48
15003822-5	2004	On the other hand, granulocyte differentiation by Fes was mediated through activation of CCAAT/enhancer-binding protein alpha (C/EBP-alpha) and STAT3, two transcription factors that are critical for granulocytic differentiation.	Iron	50-53	CCAAT enhancer binding protein alpha	Homo sapiens	89-125
15003822-5	2004	On the other hand, granulocyte differentiation by Fes was mediated through activation of CCAAT/enhancer-binding protein alpha (C/EBP-alpha) and STAT3, two transcription factors that are critical for granulocytic differentiation.	Iron	50-53	CCAAT enhancer binding protein alpha	Homo sapiens	127-138
15003822-5	2004	On the other hand, granulocyte differentiation by Fes was mediated through activation of CCAAT/enhancer-binding protein alpha (C/EBP-alpha) and STAT3, two transcription factors that are critical for granulocytic differentiation.	Iron	50-53	signal transducer and activator of transcription 3	Homo sapiens	144-149
15123270-0	2004	Identification of small molecule inhibitors that distinguish between non-transferrin bound iron uptake and transferrin-mediated iron transport.	Iron	91-95	transferrin	Homo sapiens	73-84
15123270-0	2004	Identification of small molecule inhibitors that distinguish between non-transferrin bound iron uptake and transferrin-mediated iron transport.	Iron	128-132	transferrin	Homo sapiens	107-118
15123270-3	2004	Using this approach, we screened the National Cancer Institute"s Diversity Set library for inhibitors of non-transferrin bound iron uptake.	Iron	127-131	transferrin	Homo sapiens	109-120
15123270-5	2004	Of these ten compounds, only two blocked uptake of iron mediated by transferrin.	Iron	51-55	transferrin	Homo sapiens	68-79
14985219-1	2004	BACKGROUND: We previously showed that iron supplementation significantly improves iron status and maximal work capacity in previously untrained, marginally iron-deficient women with a baseline serum transferrin receptor concentration &gt; 8.0 mg/L.	Iron	38-42	transferrin	Homo sapiens	199-210
15056890-0	2004	Effect of transferrin on enhancing bioavailability of iron.	Iron	54-58	transferrin	Rattus norvegicus	10-21
15056890-3	2004	With addition of 10 and 20 mg of purified transferrin/ml, however, ratios of absorbed iron through duodenum segments were significantly increased to 52.7 and 57.9%, respectively.	Iron	86-90	transferrin	Rattus norvegicus	42-53
15056890-5	2004	Results of the animal experiment for comparing bioavailabilities of different irons showed that irons in Fe-transferrin extract was most efficiently absorbed and incorporated into hemoglobin generation in anemic rats.	Iron	78-83	transferrin	Rattus norvegicus	108-119
15056890-5	2004	Results of the animal experiment for comparing bioavailabilities of different irons showed that irons in Fe-transferrin extract was most efficiently absorbed and incorporated into hemoglobin generation in anemic rats.	Iron	96-101	transferrin	Rattus norvegicus	108-119
15056890-5	2004	Results of the animal experiment for comparing bioavailabilities of different irons showed that irons in Fe-transferrin extract was most efficiently absorbed and incorporated into hemoglobin generation in anemic rats.	Iron	105-107	transferrin	Rattus norvegicus	108-119
15056891-5	2004	We observed that the hematocrit (Ht), serum Fe concentration and transferrin saturation (%) were each reduced in those rats fed less than 20 mg/kg Fe in a dose-dependent manner.	Iron	147-149	transferrin	Rattus norvegicus	65-76
14972637-4	2004	The principal advantage to serum transferrin receptor is the lack of a response to anemia of chronic disease (ACD), which affects other iron status indicators, for example, ferritin and transferrin saturation.	Iron	136-140	transferrin	Homo sapiens	33-44
14972637-7	2004	Serum transferrin receptor can be best used in diagnosing iron disorders, especially for patients with pathologies that may affect iron metabolism.	Iron	58-62	transferrin	Homo sapiens	6-17
14961065-3	2004	We show that this Mphi vector can be induced to produce IFNgamma under normoxic conditions by stimulation with picolinic acid (PA), a catabolite of tryptophan, or desferrioxamine (DFX), an iron-chelating drug.	Iron	189-193	interferon gamma	Mus musculus	56-64
15090958-15	2004	Plasma iron-binding antioxidant protection was negatively correlated (r = -.741, p &lt;.05) with albumin content in the treatment group but not the placebo group.	Iron	7-11	albumin	Homo sapiens	97-104
14767009-2	2004	METHODS: To quantify and compare the size of the labile fraction in several classes of IV iron agents, we examined iron donation to transferrin (Tf) in vitro.	Iron	115-119	transferrin	Homo sapiens	145-147
15017332-0	2004	Iron status of children with phenylketonuria undergoing nutrition therapy assessed by transferrin receptors.	Iron	0-4	transferrin	Homo sapiens	86-97
15058755-9	2004	There was a deficient intake of energy and iron in 52.5%, of Vit.	Iron	43-47	vitrin	Homo sapiens	61-64
15009675-6	2004	Application of FAC to astrocyte cultures caused a strong increase in the cellular content of the iron storage protein ferritin and a decrease in the amount of transferrin receptor (TfR), which is involved in the transferrin-mediated uptake of iron into cells.	Iron	243-247	transferrin	Rattus norvegicus	159-170
14988440-1	2004	Body iron status regulates ferroportin-1 (FPN1) expression such that intestinal mRNA levels are enhanced by anemia, whereas liver transcripts are increased by iron overload.	Iron	5-9	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	27-40
14988440-1	2004	Body iron status regulates ferroportin-1 (FPN1) expression such that intestinal mRNA levels are enhanced by anemia, whereas liver transcripts are increased by iron overload.	Iron	5-9	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	42-46
14988440-1	2004	Body iron status regulates ferroportin-1 (FPN1) expression such that intestinal mRNA levels are enhanced by anemia, whereas liver transcripts are increased by iron overload.	Iron	159-163	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	27-40
14988440-1	2004	Body iron status regulates ferroportin-1 (FPN1) expression such that intestinal mRNA levels are enhanced by anemia, whereas liver transcripts are increased by iron overload.	Iron	159-163	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	42-46
14988440-9	2004	These data indicate that tissue copper deficiency does not alter FPN1 expression but that copper adequacy may be required for appropriate regulation of FPN1 by iron status.	Iron	160-164	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	152-156
14767009-4	2004	Comparing results to serum samples without added iron, we calculated delta Tf-bound iron for each agent at each concentration.	Iron	84-88	transferrin	Homo sapiens	75-77
14767009-5	2004	Finally, we compared delta Tf-bound iron to the concentration of added agent and calculated the percent iron donation to Tf.	Iron	36-40	transferrin	Homo sapiens	27-29
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	32-36	transferrin	Homo sapiens	23-25
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	32-36	transferrin	Homo sapiens	99-101
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	58-62	transferrin	Homo sapiens	23-25
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	58-62	transferrin	Homo sapiens	99-101
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	58-62	transferrin	Homo sapiens	23-25
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	58-62	transferrin	Homo sapiens	99-101
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	58-62	transferrin	Homo sapiens	23-25
14767009-6	2004	RESULTS: We found that Tf-bound iron increased with added iron concentration for each agent: delta Tf-bound iron was directly related to the concentration and type of iron agent (P&lt;0.001).	Iron	58-62	transferrin	Homo sapiens	99-101
14767009-7	2004	Mean percent iron donation to Tf ranged from 2.5 to 5.8% with the following progression: iron dextran-Dexferrum&lt;iron dextran-INFeD&lt;iron sucrose&lt;ferric gluconate.	Iron	13-17	transferrin	Homo sapiens	30-32
14767009-9	2004	CONCLUSIONS: Approximately 2-6% of total iron in commonly used IV iron compounds is available for in vitro iron donation to Tf.	Iron	41-45	transferrin	Homo sapiens	124-126
14767009-9	2004	CONCLUSIONS: Approximately 2-6% of total iron in commonly used IV iron compounds is available for in vitro iron donation to Tf.	Iron	66-70	transferrin	Homo sapiens	124-126
14767009-9	2004	CONCLUSIONS: Approximately 2-6% of total iron in commonly used IV iron compounds is available for in vitro iron donation to Tf.	Iron	66-70	transferrin	Homo sapiens	124-126
15031665-9	2004	The target genes of HIF-1 are especially related to angiogenesis, cell proliferation/survival, and glucose/iron metabolism.	Iron	107-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
15095869-5	2004	In the absence of exogenous ligands (e.g. O2), the cytoglobin distal HisE7 residue is coordinated to the heme Fe atom, thus decreasing the ligand affinity.	Iron	110-112	cytoglobin	Homo sapiens	51-61
15007100-2	2004	In this review, high-affinity iron uptake systems, which allow meningococci to utilize the human host proteins transferrin, lactoferrin, hemoglobin, and haptoglobin-hemoglobin as sources of essential iron, are described.	Iron	30-34	transferrin	Homo sapiens	111-122
15007100-2	2004	In this review, high-affinity iron uptake systems, which allow meningococci to utilize the human host proteins transferrin, lactoferrin, hemoglobin, and haptoglobin-hemoglobin as sources of essential iron, are described.	Iron	200-204	transferrin	Homo sapiens	111-122
14534306-1	2004	Exploratory outlier identification methods and confirmatory gene expression studies showed induction of the iron regulon in Saccharomyces cerevisiae lacking Mac1p, a copper-responsive transcription factor.	Iron	108-112	Mac1p	Saccharomyces cerevisiae S288C	157-162
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	13-17	transferrin	Homo sapiens	40-51
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	13-17	transferrin	Homo sapiens	53-55
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	19-21	transferrin	Homo sapiens	40-51
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	19-21	transferrin	Homo sapiens	53-55
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	110-112	transferrin	Homo sapiens	40-51
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	110-112	transferrin	Homo sapiens	53-55
14980223-1	2004	Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR).	Iron	0-4	transferrin	Homo sapiens	108-119
14769622-4	2004	Since the introduction of epoetin alfa, a greater understanding of anemia pathophysiology and the interactions of erythropoietin, iron, and erythropoiesis has been elucidated.	Iron	130-134	erythropoietin	Homo sapiens	26-33
14534306-5	2004	New or additional support for a role in copper and iron homeostasis is provided in this study for the gene products of AKR1, MRS4, PCA1, SSU1, TIS11, YBR047W, YHL035C, YHR045W, YLR047C, YLR126C, and YTP1.	Iron	51-55	cation-transporting P-type ATPase PCA1	Saccharomyces cerevisiae S288C	131-135
15075998-8	2004	Patients with prolonged prothrombin time had significant lower values of haemoglobin, iron, proteins, cholesterol and serum aspartate transaminase, and significantly higher prevalence of diarrhoea, weight loss, abdominal pain and low bone mineral density in comparison with patients with normal prothrombin time.	Iron	86-90	coagulation factor II, thrombin	Homo sapiens	24-35
14720453-3	2004	Phenotypic screening of adults using transferrin saturation and serum ferritin levels identifies the majority of individuals who develop iron overload.	Iron	137-141	transferrin	Homo sapiens	37-48
14755578-1	2004	Certain anions have been shown experimentally to influence the rate of iron release from human serum transferrin (HST), implying the existence of one or more allosteric kinetically significant anion-binding (KISAB) sites on or near the surface of the protein.	Iron	71-75	transferrin	Homo sapiens	101-112
14755578-1	2004	Certain anions have been shown experimentally to influence the rate of iron release from human serum transferrin (HST), implying the existence of one or more allosteric kinetically significant anion-binding (KISAB) sites on or near the surface of the protein.	Iron	71-75	fibroblast growth factor 4	Homo sapiens	114-117
14755578-6	2004	Finally, three anions already shown experimentally to demonstrate varied effects on HST iron-release kinetics were placed at each potential site; molecular dynamics and molecular mechanics calculations were performed in order to elucidate the hydrogen-bonding environment around each anion of the protein as well as to calculate anion-protein-binding energies.	Iron	88-92	fibroblast growth factor 4	Homo sapiens	84-87
15036355-4	2004	Treatment of E47 cells with arachidonic acid plus iron (AA + Fe) was previously reported to produce synergistic toxicity in E47 cells by a mechanism dependent on CYP2E1 activity and involving oxidative stress and lipid peroxidation.	Iron	50-54	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	162-168
14643898-4	2004	Both pathways depend on acidification of the compartments in which iron release from transferrin takes place.	Iron	67-71	transferrin	Homo sapiens	85-96
14643898-7	2004	Linkage of cellular iron uptake to release of the synergistic anion (without which iron is not bound by transferrin) is particularly evident in the receptor-independent pathway.	Iron	20-24	transferrin	Homo sapiens	104-115
14729300-1	2004	A series of new iron(III) and copper(II) complexes of bovine serum transferrin (BTf), with carbonate and/or oxalate as the synergistic anion, are presented.	Iron	16-20	transferrin	Homo sapiens	67-78
14724150-6	2004	In contrast, the iron permease Ireg1 localised to the basolateral membrane in both control and sla mice.	Iron	17-21	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	31-36
14643898-0	2004	Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells.	Iron	116-120	transferrin	Homo sapiens	67-78
14643898-1	2004	To secure iron from transferrin, hepatocytes use two pathways, one dependent on transferrin receptor (TfR 1) and the other, of greater capacity but lower affinity, independent of TfR 1.	Iron	10-14	transferrin	Homo sapiens	20-31
15036355-4	2004	Treatment of E47 cells with arachidonic acid plus iron (AA + Fe) was previously reported to produce synergistic toxicity in E47 cells by a mechanism dependent on CYP2E1 activity and involving oxidative stress and lipid peroxidation.	Iron	61-63	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	162-168
14729944-0	2004	Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	29-33
14747685-8	2004	The high-iron diet reduced GPx (P &lt; 0.0001), CAT (P &lt; 0.0005), SOD (P &lt; 0.05), and GST (P &lt; 0.005) activities regardless of ascorbic acid supplementation.	Iron	9-13	catalase	Mus musculus	48-51
14729944-1	2004	Iron regulatory protein 2 (IRP2), a central posttranscriptional regulator of cellular and systemic iron metabolism, undergoes proteasomal degradation in iron-replete cells.	Iron	99-103	iron responsive element binding protein 2	Homo sapiens	0-25
14729944-1	2004	Iron regulatory protein 2 (IRP2), a central posttranscriptional regulator of cellular and systemic iron metabolism, undergoes proteasomal degradation in iron-replete cells.	Iron	99-103	iron responsive element binding protein 2	Homo sapiens	27-31
14729944-1	2004	Iron regulatory protein 2 (IRP2), a central posttranscriptional regulator of cellular and systemic iron metabolism, undergoes proteasomal degradation in iron-replete cells.	Iron	153-157	iron responsive element binding protein 2	Homo sapiens	0-25
14729944-1	2004	Iron regulatory protein 2 (IRP2), a central posttranscriptional regulator of cellular and systemic iron metabolism, undergoes proteasomal degradation in iron-replete cells.	Iron	153-157	iron responsive element binding protein 2	Homo sapiens	27-31
14729944-3	2004	By expressing wild-type and mutated versions of IRP2 in H1299 cells, we find that a C168S C174S C178S triple mutant, or a deletion mutant lacking the entire "73-aa domain," is sensitive to iron-mediated degradation, like wild-type IRP2.	Iron	189-193	iron responsive element binding protein 2	Homo sapiens	48-52
14729944-5	2004	The pathway for IRP2 degradation is saturable, which may explain earlier data supporting the "cysteine oxidation model," and shows remarkable similarities with the degradation of the hypoxia-inducible factor 1 alpha (HIF-1 alpha): dimethyl-oxalylglycine, a specific inhibitor of 2-oxoglutarate-dependent oxygenases, stabilizes IRP2 following the administration of iron to iron-deficient cells.	Iron	364-368	iron responsive element binding protein 2	Homo sapiens	16-20
14729944-5	2004	The pathway for IRP2 degradation is saturable, which may explain earlier data supporting the "cysteine oxidation model," and shows remarkable similarities with the degradation of the hypoxia-inducible factor 1 alpha (HIF-1 alpha): dimethyl-oxalylglycine, a specific inhibitor of 2-oxoglutarate-dependent oxygenases, stabilizes IRP2 following the administration of iron to iron-deficient cells.	Iron	364-368	hypoxia inducible factor 1 subunit alpha	Homo sapiens	183-215
14729944-5	2004	The pathway for IRP2 degradation is saturable, which may explain earlier data supporting the "cysteine oxidation model," and shows remarkable similarities with the degradation of the hypoxia-inducible factor 1 alpha (HIF-1 alpha): dimethyl-oxalylglycine, a specific inhibitor of 2-oxoglutarate-dependent oxygenases, stabilizes IRP2 following the administration of iron to iron-deficient cells.	Iron	364-368	hypoxia inducible factor 1 subunit alpha	Homo sapiens	217-228
14729944-5	2004	The pathway for IRP2 degradation is saturable, which may explain earlier data supporting the "cysteine oxidation model," and shows remarkable similarities with the degradation of the hypoxia-inducible factor 1 alpha (HIF-1 alpha): dimethyl-oxalylglycine, a specific inhibitor of 2-oxoglutarate-dependent oxygenases, stabilizes IRP2 following the administration of iron to iron-deficient cells.	Iron	372-376	iron responsive element binding protein 2	Homo sapiens	16-20
14729944-5	2004	The pathway for IRP2 degradation is saturable, which may explain earlier data supporting the "cysteine oxidation model," and shows remarkable similarities with the degradation of the hypoxia-inducible factor 1 alpha (HIF-1 alpha): dimethyl-oxalylglycine, a specific inhibitor of 2-oxoglutarate-dependent oxygenases, stabilizes IRP2 following the administration of iron to iron-deficient cells.	Iron	372-376	hypoxia inducible factor 1 subunit alpha	Homo sapiens	183-215
14729944-5	2004	The pathway for IRP2 degradation is saturable, which may explain earlier data supporting the "cysteine oxidation model," and shows remarkable similarities with the degradation of the hypoxia-inducible factor 1 alpha (HIF-1 alpha): dimethyl-oxalylglycine, a specific inhibitor of 2-oxoglutarate-dependent oxygenases, stabilizes IRP2 following the administration of iron to iron-deficient cells.	Iron	372-376	hypoxia inducible factor 1 subunit alpha	Homo sapiens	217-228
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	232-241
14705946-2	2004	In its iron-donating cycle, transferrin is first captured by the transferrin receptor on the cell membrane, and then internalized to a proton-pumping endosome where iron is released.	Iron	7-11	transferrin	Homo sapiens	28-39
14705946-2	2004	In its iron-donating cycle, transferrin is first captured by the transferrin receptor on the cell membrane, and then internalized to a proton-pumping endosome where iron is released.	Iron	7-11	transferrin	Homo sapiens	65-76
14705946-2	2004	In its iron-donating cycle, transferrin is first captured by the transferrin receptor on the cell membrane, and then internalized to a proton-pumping endosome where iron is released.	Iron	165-169	transferrin	Homo sapiens	28-39
14705946-2	2004	In its iron-donating cycle, transferrin is first captured by the transferrin receptor on the cell membrane, and then internalized to a proton-pumping endosome where iron is released.	Iron	165-169	transferrin	Homo sapiens	65-76
14981211-7	2004	Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin).	Iron	23-27	protoporphyrinogen oxidase	Mus musculus	168-194
14705946-1	2004	Virtually all organisms require iron, and iron-dependent cells of vertebrates (and some more ancient species) depend on the Fe(3+)-binding protein of the circulation, transferrin, to meet their needs.	Iron	32-36	transferrin	Homo sapiens	167-178
14705946-1	2004	Virtually all organisms require iron, and iron-dependent cells of vertebrates (and some more ancient species) depend on the Fe(3+)-binding protein of the circulation, transferrin, to meet their needs.	Iron	42-46	transferrin	Homo sapiens	167-178
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	366-375
14573596-0	2004	Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.	Iron	37-41	pirin	Homo sapiens	27-32
14573596-6	2004	The structure suggests an interesting new role of iron in biology and that Pirin may be involved in novel mechanisms of gene regulation.	Iron	50-54	pirin	Homo sapiens	75-80
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	232-241
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	366-375
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	232-241
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	366-375
14684153-5	2004	The MAbs made it possible to demonstrate that 45-48 kDa PvdA homologues are expressed in response to iron limitation by different species and strains of fluorescent pseudomonads.	Iron	101-105	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	56-60
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	232-241
14684153-7	2004	The MAb library was also used to monitor PvdA expression during the transition of P. aeruginosa from iron-sufficient to iron-deficient growth.	Iron	101-105	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	41-45
14684153-7	2004	The MAb library was also used to monitor PvdA expression during the transition of P. aeruginosa from iron-sufficient to iron-deficient growth.	Iron	120-124	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	41-45
14960188-3	2004	Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM.	Iron	132-136	tumor necrosis factor	Rattus norvegicus	366-375
14988642-2	2004	Iron is present in end proteins of the delta6-desaturase enzyme complex, and vitamin B6 deficiency can affect the transmethylation reaction of proteins.	Iron	0-4	fatty acid desaturase 2	Homo sapiens	39-56
14684399-1	2004	BACKGROUND: Excessive iron stores may promote insulin resistance and lead to the development of type 2 diabetes.	Iron	22-26	insulin	Homo sapiens	46-53
14647950-5	2004	The method was applied to the separation and quantification of transferrin glycoforms in serum from a healthy, non-pregnant woman, after saturation of transferrin with iron and further precipitation of lipoproteins.	Iron	168-172	transferrin	Homo sapiens	63-74
14732819-1	2004	The correction of anemia in dialysis patients with erythropoietin (EPO) can be frustrated by insufficient iron.	Iron	106-110	erythropoietin	Homo sapiens	51-65
14739596-1	2004	Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes oxidative degradation of heme to form biliverdin, carbon monoxide (CO), and free iron.	Iron	143-147	heme oxygenase 1	Mus musculus	0-16
14739596-1	2004	Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes oxidative degradation of heme to form biliverdin, carbon monoxide (CO), and free iron.	Iron	143-147	heme oxygenase 1	Mus musculus	18-22
14744237-2	2004	Ethanol, polyunsaturated fatty acids, and iron were found to be cytotoxic in HepG2 cells that overexpress CYP2E1.	Iron	42-46	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	106-112
14732819-1	2004	The correction of anemia in dialysis patients with erythropoietin (EPO) can be frustrated by insufficient iron.	Iron	106-110	erythropoietin	Homo sapiens	67-70
14732819-2	2004	To address this effect, we preloaded candidate EPO patients with intravenous iron in the early 1990s.	Iron	77-81	erythropoietin	Homo sapiens	47-50
14732819-3	2004	Preloading with 900-1,525 mg of iron yielded the following results: 70% of patients had increasing hematocrits (HCTs) without EPO, and 40% of patients had HCTs greater than 30%.	Iron	32-36	erythropoietin	Homo sapiens	126-129
15196322-3	2004	It may be even more critical to replace iron when erythropoietin therapy is used because of the consumption of iron stores that occurs during heme synthesis.	Iron	111-115	erythropoietin	Homo sapiens	50-64
14726713-6	2004	Iron is central to the oxygen sensing mechanism, and sensitivity to other metals, namely cobalt and nickel, is a distinctive feature of the HIF system; in fact, this is often used as an initial way of implicating HIF-1 in a biological response.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	213-218
15314261-8	2004	An altered iron distribution would be predicted to indirectly limit APP holoprotein expression and Abeta peptide secretion.	Iron	11-15	amyloid beta precursor protein	Homo sapiens	99-104
15579097-2	2004	It affects cellular acquisition of iron by binding to transferrin, and it interacts with the iron-dependent enzyme ribonucleotide reductase, resulting in reduced dNTP pools and inhibition of DNA synthesis.	Iron	35-39	transferrin	Homo sapiens	54-65
14745427-0	2004	Non-transferrin-bound serum iron (NTBI) in megaloblastic anemia: effect of vitamin B(12) treatment.	Iron	28-32	transferrin	Homo sapiens	4-15
15621682-4	2004	Holo-transferrin (Tf) containing two iron atoms (Fe(3+)), has a much higher affinity for the Tf receptor than apo-Tf (which does not contain any Fe(3+)).	Iron	37-41	transferrin	Homo sapiens	5-16
14675167-2	2004	In adult rats, brain uptake of transferrin-bound iron injected intravenously (i.v.)	Iron	49-53	transferrin	Rattus norvegicus	31-42
14675167-9	2004	Neuronal expression of transferrin receptors and DMT1 in adult rats implies that neurones at this age acquire iron by receptor-mediated endocytosis of transferrin followed by iron transport out of endosomes mediated by DMT1.	Iron	110-114	transferrin	Rattus norvegicus	23-34
14675167-9	2004	Neuronal expression of transferrin receptors and DMT1 in adult rats implies that neurones at this age acquire iron by receptor-mediated endocytosis of transferrin followed by iron transport out of endosomes mediated by DMT1.	Iron	110-114	transferrin	Rattus norvegicus	151-162
14675167-9	2004	Neuronal expression of transferrin receptors and DMT1 in adult rats implies that neurones at this age acquire iron by receptor-mediated endocytosis of transferrin followed by iron transport out of endosomes mediated by DMT1.	Iron	175-179	transferrin	Rattus norvegicus	23-34
15548871-0	2004	Heme oxygenase-2 products activate IKCa: role of CO and iron in guinea pig portal vein smooth muscle cells.	Iron	56-60	heme oxygenase 2	Cavia porcellus	0-16
14684575-0	2004	Ferroportin/IREG-1/MTP-1/SLC40A1 modulates the uptake of iron at the apical membrane of enterocytes.	Iron	57-61	solute carrier family 40 member 1	Rattus norvegicus	25-32
14740507-12	2004	Heterozygous individuals with higher transferrin saturation values may be protected against iron loss but may also be more susceptible for certain liver diseases, depending on the simultaneous prevalence of other diseases.	Iron	92-96	transferrin	Homo sapiens	37-48
14688618-10	2004	In contrast, in Belgrade rats, whose brain is iron deficient, the expression of both divalent metal transporter 1 and transferrin receptor was increased compared with control in almost all brain regions examined, but not transferrin or ferritin.	Iron	46-50	transferrin	Rattus norvegicus	118-129
15582941-6	2004	The distribution of cells containing iron, indicating an increase of HO-1 in the red pulp, was detected with Berlin blue staining.	Iron	37-41	heme oxygenase 1	Mus musculus	69-73
14618243-11	2004	Rather, the duodenal ferric reductase Dcytb may act as a possible mediator of iron overload in Hfe deficiency.	Iron	78-82	cytochrome b reductase 1	Mus musculus	38-43
15151266-1	2004	Adequate iron stores are a prerequisite for successful erythropoietin (EPO) therapy in hemodialysis (HD) patients.	Iron	9-13	erythropoietin	Homo sapiens	55-69
15151266-1	2004	Adequate iron stores are a prerequisite for successful erythropoietin (EPO) therapy in hemodialysis (HD) patients.	Iron	9-13	erythropoietin	Homo sapiens	71-74
15151266-13	2004	In patients with elevated CRP levels, it is very difficult to reach target iron status levels without exceeding the upper limits for serum ferritin.	Iron	75-79	C-reactive protein	Homo sapiens	26-29
14971437-4	2004	An adequate intake of iron, zinc and vitamins A, E, B6 and B12 is particularly important for the maintenance of immune function, but excess intakes of some micronutrients can also impair immune function and have other adverse effects on health.	Iron	22-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	59-62
15022609-5	2004	Decreasing concentrations of IL-1, IL-6, TNF-alpha and INF-gamma in IDA patients due to an adequate therapy by iron-containing drugs is a positive phenomenon in recovering the functional status of the immune system; it denotes that the maturation of hemoglobin-containing erythron variations and the secondary immune insufficiency are reviving.	Iron	111-115	interleukin 6	Homo sapiens	35-39
14770366-6	2004	Macrophages play also an important role in iron delivery to plasma transferrin through phagocytosis of senescent red blood cell, heme catabolism and recycling of iron.	Iron	43-47	transferrin	Homo sapiens	67-78
14770366-6	2004	Macrophages play also an important role in iron delivery to plasma transferrin through phagocytosis of senescent red blood cell, heme catabolism and recycling of iron.	Iron	162-166	transferrin	Homo sapiens	67-78
15488650-4	2004	Once gut/blood brain barrier permeability is impaired, the increased uptake of Al, Fe, Sr, Ba, or Mn into the Mg/Ca depleted brain leads to rogue metal substitutions at the Mg/Ca vacated binding domains on various enzyme/proteoglycan groups, causing a broad ranging disruption in Mg/Ca dependent systems - such as the glutamine synthetase which prevents the accumulation of neurotoxic glutamate.	Iron	83-85	glutamate-ammonia ligase	Homo sapiens	318-338
15224760-1	2004	Hemodialysis patients on maintenance erythropoietin need an adequate supply of iron to optimize therapy and achieve and maintain target levels of hemoglobin.	Iron	79-83	erythropoietin	Homo sapiens	37-51
14975519-4	2004	Oxygen free radicals are produced only by free iron, but stored body iron markers reflect iron bound to ferritin or transferrin, which are produced to sequester catalytically active free iron.	Iron	69-73	transferrin	Homo sapiens	116-127
14975519-4	2004	Oxygen free radicals are produced only by free iron, but stored body iron markers reflect iron bound to ferritin or transferrin, which are produced to sequester catalytically active free iron.	Iron	69-73	transferrin	Homo sapiens	116-127
14975519-4	2004	Oxygen free radicals are produced only by free iron, but stored body iron markers reflect iron bound to ferritin or transferrin, which are produced to sequester catalytically active free iron.	Iron	69-73	transferrin	Homo sapiens	116-127
14975519-7	2004	It is generally believed that free iron rarely exists, except in iron-overload with 100% transferrin saturation.	Iron	65-69	transferrin	Homo sapiens	89-100
14975519-8	2004	However, some recent studies find non-transferrin bound iron (NTBI) or the intracellular labile iron pool (LIP) in the presence of triggers disturbing iron homeostasis, such as alcohol consumption.	Iron	56-60	transferrin	Homo sapiens	38-49
14671049-8	2004	Both unadjusted and multivariate adjusted correlation coefficients (r) for serum ferritin and CRP vs pertinent values were statistically significant for DMS and MIS and some other measures of nutritional status and iron indices.	Iron	215-219	C-reactive protein	Homo sapiens	94-97
15627796-1	2004	BACKGROUND: Angiotensin II infusion into rats causes iron deposition in the kidney, which may augment the pro-proteinuric effects of this octapeptide.	Iron	53-57	angiotensinogen	Rattus norvegicus	12-26
15627796-2	2004	We have investigated whether administration of iron mimics the renal damage induced by angiotensin II.	Iron	47-51	angiotensinogen	Rattus norvegicus	87-101
15627796-6	2004	Prussian blue staining showed that iron deposition was observed mainly in the glomerular and medullar regions in the iron dextran-treated rats, but in the tubular epithelial cells in angiotensin II-infused rats.	Iron	35-39	angiotensinogen	Rattus norvegicus	183-197
15022609-5	2004	Decreasing concentrations of IL-1, IL-6, TNF-alpha and INF-gamma in IDA patients due to an adequate therapy by iron-containing drugs is a positive phenomenon in recovering the functional status of the immune system; it denotes that the maturation of hemoglobin-containing erythron variations and the secondary immune insufficiency are reviving.	Iron	111-115	tumor necrosis factor	Homo sapiens	41-50
15645737-10	2004	The recombinant erythropoietin dose remained stable for three months in the ascorbic acid, iron, and control groups, respectively.	Iron	91-95	erythropoietin	Homo sapiens	16-30
15013638-1	2004	Transferrin (TF), a 76-80 kDa glycoprotein, is responsible for the transport of iron to cells within both the fetal and maternal systems, but it does not cross the multiple cell layer barrier of the placenta.	Iron	80-84	transferrin	Rattus norvegicus	0-11
16228609-4	2004	On the basis of X-ray crystallographic studies of cytochrome bc (1), it has been proposed that the Rieske iron-sulfur protein undergoes large conformational changes as it transports electrons from ubiquinol to cytochrome c (1).	Iron	106-110	cytochrome c, somatic	Homo sapiens	210-222
16228609-6	2004	The rate constant for electron transfer from the iron-sulfur center to cytochrome c (1) was found to be 80,000 s(-1), and is controlled by the dynamics of conformational changes in the iron-sulfur protein.	Iron	49-53	cytochrome c, somatic	Homo sapiens	71-83
15013638-1	2004	Transferrin (TF), a 76-80 kDa glycoprotein, is responsible for the transport of iron to cells within both the fetal and maternal systems, but it does not cross the multiple cell layer barrier of the placenta.	Iron	80-84	transferrin	Rattus norvegicus	13-15
15013638-7	2004	When taken together, these results demonstrate clearly that TF is expressed by both differentiated and non-differentiated placental cells, and when viewed in light of previous findings, strengthen the possibility that placental TF may be central to the passage of iron from the mother to the fetus during development.	Iron	264-268	transferrin	Rattus norvegicus	60-62
15013638-7	2004	When taken together, these results demonstrate clearly that TF is expressed by both differentiated and non-differentiated placental cells, and when viewed in light of previous findings, strengthen the possibility that placental TF may be central to the passage of iron from the mother to the fetus during development.	Iron	264-268	transferrin	Rattus norvegicus	228-230
15719887-13	2004	CONCLUSIONS: Hypochromic reticulocytes, hypochromic erythrocytes and p-transferrin receptors are sensitive variables in the early detection of iron-deficient erythropoiesis in healthy subjects, but in this study the iron withdrawal period was too short to show the value of these variables in the detection of iron-deficient erythropoiesis in hemodialysis patients.	Iron	143-147	transferrin	Homo sapiens	71-82
15822631-4	2004	The pathophysiology of RLS is related to dopamine transmission insufficiency, low iron storage in substantia nigra neurons, and spinal cord dysfunction.	Iron	82-86	RLS1	Homo sapiens	23-26
15217740-4	2004	Maternal serum iron levels were positively correlated with the newborns" TIBC (r = 0.362, p&lt;0.05), maternal ferritin with neonatal transferrin (r = 0.374, p&lt;0.05), maternal transferrin coefficient of saturation (CS) with neonatal TIBC (r = 0.554, p&lt;0.01).	Iron	15-19	transferrin	Homo sapiens	134-145
15217740-4	2004	Maternal serum iron levels were positively correlated with the newborns" TIBC (r = 0.362, p&lt;0.05), maternal ferritin with neonatal transferrin (r = 0.374, p&lt;0.05), maternal transferrin coefficient of saturation (CS) with neonatal TIBC (r = 0.554, p&lt;0.01).	Iron	15-19	transferrin	Homo sapiens	179-190
14523005-0	2003	Pse1p mediates the nuclear import of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.	Iron	41-45	Pse1p	Saccharomyces cerevisiae S288C	0-5
14692760-1	2003	Heme oxygenase (HO) catalyzes the O2 and NADPH/cytochrome P450 reductase-dependent conversion of heme to biliverdin, free iron ion, and CO through a process in which the heme participates as both dioxygen-activating prosthetic group and substrate.	Iron	122-126	cytochrome p450 oxidoreductase	Homo sapiens	41-72
14728980-4	2004	The exposure of cells to cobalt (Co), hypoxia, the iron chelator deferoxamine, and the proline hydroxylase inhibitor dimethyloxalylglycine (DMOG) also down-regulated serpina3g transcription to similar extents as soluble Ni exposure.	Iron	51-55	serine (or cysteine) peptidase inhibitor, clade A, member 3G	Mus musculus	166-175
15013295-3	2004	Recently, the soluble transferrin receptor (s-TfR) has been considered to be a marker of functional iron stores.	Iron	100-104	transferrin	Homo sapiens	22-33
12966104-4	2003	These are reminiscent of the mechanism of cytochrome P-450, where a heme iron stabilizes the activated O2 species.	Iron	73-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-58
14523005-8	2003	Supporting this is that the induction of an Aft1p target gene, FTR1, in response to iron starvation was greatly reduced in pse1-1 cells.	Iron	84-88	Pse1p	Saccharomyces cerevisiae S288C	123-127
14523005-5	2003	In pse1-1 cells, which bear a temperature-sensitive mutation of PSE1, Aft1p was misdirected to the cytoplasm during iron starvation at the restrictive temperature.	Iron	116-120	Pse1p	Saccharomyces cerevisiae S288C	3-7
14523005-5	2003	In pse1-1 cells, which bear a temperature-sensitive mutation of PSE1, Aft1p was misdirected to the cytoplasm during iron starvation at the restrictive temperature.	Iron	116-120	Pse1p	Saccharomyces cerevisiae S288C	64-68
14657394-5	2003	In this article, we describe in vitro experiments using purified mitochondrial cytochrome P450scc (CYP11A1) reconstituted with the iron-sulfer protein, adrenodoxin, and the flavoprotein, adrenodoxin reductase, and show the NADPH and time-dependent formation of two major metabolites of D3 (i.e., 20-hydroxyvitamin D3 and 20,22-dihydroxyvitamin D3) plus two unknown minor metabolites.	Iron	131-135	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	99-106
12958019-0	2003	DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption.	Iron	69-73	solute carrier family 40 member 1	Rattus norvegicus	9-13
14504288-3	2003	The small Maf proteins appear to be critical regulators of heme oxygenase (HO)-1, an anti-oxidant defense enzyme that degrades heme into iron, carbon monoxide, and biliverdin.	Iron	137-141	MAF bZIP transcription factor	Homo sapiens	10-13
14668284-10	2003	By day 20, DMT1 and FPN1 expression and iron absorption had decreased significantly with iron supplementation.	Iron	89-93	solute carrier family 40 member 1	Rattus norvegicus	20-24
14668457-7	2003	In contrast, fibroatheromas with cores in a late stage of necrosis or thin caps had a marked increase in glycophorin A in regions of cholesterol clefts surrounded by iron deposits.	Iron	166-170	glycophorin A (MNS blood group)	Homo sapiens	105-118
12791678-2	2003	We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-reductase activity involving anion exchange protein 2 (AE2) and extracellular bicarbonate (HCO3-).	Iron	98-102	transferrin	Homo sapiens	80-91
14679574-1	2003	Capillary electrophoresis with a dynamic double coating formed by charged polymeric reagents represents a very effective tool for the separation of iron-saturated transferrin (Tf) isoforms and thus the determination of carbohydrate-deficient transferrin (CDT) in human serum.	Iron	148-152	transferrin	Homo sapiens	163-174
12907459-8	2003	Comparative Northern analyses of iron-related genes after erythrophagocytosis revealed a 16-fold increase in FPN1 levels after 3 hours, a 10-fold increase in heme oxygenase-1 (HO-1) after 3 hours, a 2-fold increase in natural resistance macrophage-associated protein 1 (Nramp1) levels after 6 hours, but no change in divalent metal ion transporter 1 (DMT1) levels.	Iron	33-37	solute carrier family 11 member 1	Homo sapiens	218-268
12907459-8	2003	Comparative Northern analyses of iron-related genes after erythrophagocytosis revealed a 16-fold increase in FPN1 levels after 3 hours, a 10-fold increase in heme oxygenase-1 (HO-1) after 3 hours, a 2-fold increase in natural resistance macrophage-associated protein 1 (Nramp1) levels after 6 hours, but no change in divalent metal ion transporter 1 (DMT1) levels.	Iron	33-37	solute carrier family 11 member 1	Homo sapiens	270-276
14636825-0	2003	Differing effects of two iron compounds on experimental arthritis, TNF-alpha levels and immune response in mice.	Iron	25-29	tumor necrosis factor	Mus musculus	67-76
14636286-8	2003	RESULTS: In in vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P &lt; 0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P &lt; 0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P &lt; 0.001).	Iron	32-36	interleukin 6	Homo sapiens	388-392
14606851-6	2003	This result suggests that the steric environment near the heme iron in cyt c discriminates against coordination of Met(SO)-80.	Iron	40-44	cytochrome c, somatic	Homo sapiens	71-76
14656206-5	2003	Furthermore, clusterin, alpha-2-macroglobulin precursor, prothymosin alpha and alpha-fetoprotein were found to be down-regulated by THs.Transferrin, an iron-binding protein expressed in all mammals, and mainly synthesized in the liver, was investigated further.	Iron	152-156	transferrin	Homo sapiens	136-147
14585310-7	2003	We studied the effects of a single oral dose of vitamin E taken 6 h prior to intravenous infusion of 100 mg iron, which exceeded the iron-binding capacity of transferrin.	Iron	133-137	transferrin	Homo sapiens	158-169
14691533-5	2003	We used a quantitative surface plasmon resonance assay to determine the binding affinities of an extensive set of site-directed TfR mutants to HFE and Fe-Tf at pH 7.4 and to apo-Tf at pH 6.3.	Iron	151-153	transferrin	Homo sapiens	154-156
14691533-11	2003	From these data, we propose a structure-based model for the mechanism of TfR-assisted iron release from Fe-Tf.	Iron	86-90	transferrin	Homo sapiens	73-75
14663340-0	2003	Thrombin preconditioning attenuates brain edema induced by erythrocytes and iron.	Iron	76-80	coagulation factor II, thrombin	Homo sapiens	0-8
14691292-2	2003	In nude mice TNF has been reported to impair iron metabolism and erythropoiesis, leading to anemia with a low serum iron and preserved iron stores.	Iron	45-49	tumor necrosis factor	Mus musculus	13-16
14691292-2	2003	In nude mice TNF has been reported to impair iron metabolism and erythropoiesis, leading to anemia with a low serum iron and preserved iron stores.	Iron	116-120	tumor necrosis factor	Mus musculus	13-16
14691292-2	2003	In nude mice TNF has been reported to impair iron metabolism and erythropoiesis, leading to anemia with a low serum iron and preserved iron stores.	Iron	116-120	tumor necrosis factor	Mus musculus	13-16
14745458-1	2003	OBJECTIVE: This study was undertaken to assess the role of p97 (also known as melanotransferrin) in the transfer of iron into the brain, because the passage of most large molecules is limited by the presence of the blood-brain barrier, including that of the serum iron transporter transferrin.	Iron	116-120	transferrin	Homo sapiens	84-95
14691533-2	2003	Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process.	Iron	38-42	transferrin	Homo sapiens	50-61
14691533-2	2003	Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process.	Iron	38-42	transferrin	Homo sapiens	13-15
14691533-2	2003	Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process.	Iron	131-135	transferrin	Homo sapiens	13-15
14691533-3	2003	The iron-free form of Tf (apo-Tf) remains bound to TfR and is recycled to the cell surface, where the complex dissociates upon exposure to the slightly basic pH of the blood.	Iron	4-8	transferrin	Homo sapiens	22-24
14691533-3	2003	The iron-free form of Tf (apo-Tf) remains bound to TfR and is recycled to the cell surface, where the complex dissociates upon exposure to the slightly basic pH of the blood.	Iron	4-8	transferrin	Homo sapiens	30-32
14691533-4	2003	Fe-Tf competes for binding to TfR with HFE, the protein mutated in the iron-overload disease hereditary hemochromatosis.	Iron	0-2	transferrin	Homo sapiens	3-5
14691533-5	2003	We used a quantitative surface plasmon resonance assay to determine the binding affinities of an extensive set of site-directed TfR mutants to HFE and Fe-Tf at pH 7.4 and to apo-Tf at pH 6.3.	Iron	151-153	transferrin	Homo sapiens	128-130
14615611-11	2003	CONCLUSIONS: The iron overload and upregulation of iron-handling proteins, including transferrin, transferrin receptor, and ferritin, in the brain after ICH suggest that iron could be a target for ICH therapy.	Iron	51-55	transferrin	Rattus norvegicus	85-96
14615611-11	2003	CONCLUSIONS: The iron overload and upregulation of iron-handling proteins, including transferrin, transferrin receptor, and ferritin, in the brain after ICH suggest that iron could be a target for ICH therapy.	Iron	51-55	transferrin	Rattus norvegicus	98-109
14615611-11	2003	CONCLUSIONS: The iron overload and upregulation of iron-handling proteins, including transferrin, transferrin receptor, and ferritin, in the brain after ICH suggest that iron could be a target for ICH therapy.	Iron	51-55	transferrin	Rattus norvegicus	85-96
14615611-11	2003	CONCLUSIONS: The iron overload and upregulation of iron-handling proteins, including transferrin, transferrin receptor, and ferritin, in the brain after ICH suggest that iron could be a target for ICH therapy.	Iron	51-55	transferrin	Rattus norvegicus	98-109
12881306-1	2003	Transferrin receptor (TfR) facilitates cellular iron uptake by mediating endocytosis of its ligand, iron-loaded transferrin.	Iron	48-52	transferrin	Homo sapiens	112-123
12881306-1	2003	Transferrin receptor (TfR) facilitates cellular iron uptake by mediating endocytosis of its ligand, iron-loaded transferrin.	Iron	100-104	transferrin	Homo sapiens	112-123
12960168-3	2003	These genes, FET3, FTR1, TIS11, SIT1, and FIT2, are involved in the iron uptake pathway.	Iron	68-72	siderophore transporter	Saccharomyces cerevisiae S288C	32-36
14607516-0	2003	Downregulation of p38 kinase pathway by cAMP response element-binding protein protects HL-60 cells from iron chelator-induced apoptosis.	Iron	104-108	mitogen-activated protein kinase 14	Homo sapiens	18-21
14607516-4	2003	These results led us to investigate whether CREB activation is functionally connected with the MAPK family members because we previously demonstrated that p38 kinase is involved in iron chelator-induced apoptosis of HL-60 cells.	Iron	181-185	mitogen-activated protein kinase 14	Homo sapiens	155-158
14607516-8	2003	Collectively, these results demonstrate that cAMP-dependent CREB activation plays an important role in protecting HL-60 cells from iron chelator-induced apoptosis, presumably through downregulation of p38 kinase.	Iron	131-135	mitogen-activated protein kinase 14	Homo sapiens	201-204
14614458-6	2003	This suggests that intracellular iron depletion was a trigger for apoptosis and that transferrin-bound iron rescued N.1 cells.	Iron	103-107	transferrin	Homo sapiens	85-96
14614458-8	2003	The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.	Iron	83-87	tumor necrosis factor	Homo sapiens	44-52
14614458-8	2003	The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.	Iron	83-87	TNF superfamily member 10	Homo sapiens	58-63
14614458-8	2003	The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.	Iron	175-179	transferrin	Homo sapiens	163-174
14620767-6	2003	Virulent R equi were able to use iron from ferrated deferoxamine, bovine transferrin, and bovine lactoferrin.	Iron	33-37	serotransferrin	Bos taurus	73-84
14580189-1	2003	Human transferrin, a bilobal protein, with each lobe bearing a single iron-binding site, functions to transport iron into cells.	Iron	112-116	transferrin	Homo sapiens	6-17
14580189-1	2003	Human transferrin, a bilobal protein, with each lobe bearing a single iron-binding site, functions to transport iron into cells.	Iron	70-74	transferrin	Homo sapiens	6-17
12842821-5	2003	However, iron/ascorbate-mediated lipid peroxidation promoted inhibitor-kappaB degradation and NF-kappaB activation, as well as gave rise to IL-8, cyclooxygenase-2, and ICAM-1.	Iron	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
12842821-5	2003	However, iron/ascorbate-mediated lipid peroxidation promoted inhibitor-kappaB degradation and NF-kappaB activation, as well as gave rise to IL-8, cyclooxygenase-2, and ICAM-1.	Iron	9-13	prostaglandin-endoperoxide synthase 2	Homo sapiens	146-162
12855587-1	2003	Iron regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that affect the translation and stabilization of specific mRNAs by binding to stem-loop structures known as iron responsive elements (IREs).	Iron	174-178	iron responsive element binding protein 2	Homo sapiens	35-39
12855587-4	2003	Here we describe the consequences of IRP regulation and show that iron homeostasis is regulated in 2 phases during hypoxia: an early phase where IRP1 RNA-binding activity decreases and iron uptake and Ft synthesis increase, and a late phase where IRP2 RNA-binding activity increases and iron uptake and Ft synthesis decrease.	Iron	66-70	iron responsive element binding protein 2	Homo sapiens	247-251
14636642-2	2003	Pathogenic mutations in ferroportin 1 lead to an autosomal dominant hereditary iron overload syndrome characterized by high serum ferritin concentration, normal transferrin saturation, iron accumulation predominantly in macrophages, and marginal anemia.	Iron	79-83	transferrin	Homo sapiens	161-172
14578320-3	2003	METHODS: Transferrin was iron-saturated by mixing the serum with ferric nitrilotriacetic acid, and lipoproteins were precipitated with dextran sulfate and calcium chloride.	Iron	25-29	transferrin	Homo sapiens	9-20
14578853-6	2003	Arachidonic acid (AA) plus iron-induced cell death was partially prevented in both Ad.SOD1- and Ad.SOD2-infected E47 cells.	Iron	27-31	superoxide dismutase 1	Homo sapiens	86-90
14966382-7	2003	Qualitative and quantitative immunohistochemical analyses of dendritic structure and growth using microtubule-associated protein-2 as an index showed that iron-deficient P15 pups have truncated apical dendritic morphology in CA1 and a persistence of an immature apical dendritic pattern at P65.	Iron	155-159	synaptotagmin 1	Rattus norvegicus	290-293
14578854-2	2003	In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present, but the involvement of iron in Hao1 regulation remains unclear.	Iron	104-108	hydroxyacid oxidase 1	Rattus norvegicus	3-7
14578854-2	2003	In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present, but the involvement of iron in Hao1 regulation remains unclear.	Iron	33-37	hydroxyacid oxidase 1	Rattus norvegicus	3-7
14578854-3	2003	In this study, we found a reduction of Hao1 mRNA content in livers of rats with chronic dietary iron overload, which showed decreased IRP activity and higher ferritin expression as expected, but also induction of heme oxygenase (HO-1), a marker of oxidative damage, and lipid peroxidation.	Iron	96-100	hydroxyacid oxidase 1	Rattus norvegicus	39-43
14578854-5	2003	These observations were not consistent with a post-transcriptional down-regulation of Hao1 by iron through the IRE/IRP pathway and suggested an effect of reactive oxygen species (ROS).	Iron	94-98	hydroxyacid oxidase 1	Rattus norvegicus	86-90
14578854-2	2003	In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present, but the involvement of iron in Hao1 regulation remains unclear.	Iron	33-37	hydroxyacid oxidase 1	Rattus norvegicus	215-219
14578854-2	2003	In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present, but the involvement of iron in Hao1 regulation remains unclear.	Iron	104-108	hydroxyacid oxidase 1	Rattus norvegicus	3-7
14686498-9	2003	However, there were also significant correlations between iron status as indicated by transferrin saturation or serum ferritin levels and SGOT, SGPT, and gamma-glutamyltransferase (GGT) levels.	Iron	58-62	transferrin	Homo sapiens	86-97
14551810-3	2003	How iron is released from Fbp has yet to be resolved.	Iron	4-8	ECB2	Homo sapiens	26-29
14743546-7	2003	Using a limit of 0.6 mg/L (75th percentile), significantly lower levels were observed for transthyretin, iron, retinol, and beta-carotene in the group with the higher CRP levels.	Iron	105-109	C-reactive protein	Homo sapiens	167-170
14551810-4	2003	Consequently, understanding the dynamics of iron release from Fbp is of both biological and chemical interest.	Iron	44-48	ECB2	Homo sapiens	62-65
14551810-5	2003	Fbp requires an exogenous anion, e.g. phosphate when isolated from cell lysates, for tight iron sequestration.	Iron	91-95	ECB2	Homo sapiens	0-3
14708625-0	2003	Induction of interferon regulatory factor 1 expression in human dermal endothelial cells by interferon-gamma and tumor necrosis factor-alpha is transcriptionally regulated and requires iron.	Iron	185-189	interferon regulatory factor 1	Homo sapiens	13-43
14708625-2	2003	In this study, we determined that the generation of interferon regulatory factor-1 expression in human dermal microvascular endothelial cells was transcriptionally mediated by tumor necrosis factor-alpha or interferon-gamma via iron-dependent pathways.	Iron	228-232	interferon regulatory factor 1	Homo sapiens	52-82
14708625-2	2003	In this study, we determined that the generation of interferon regulatory factor-1 expression in human dermal microvascular endothelial cells was transcriptionally mediated by tumor necrosis factor-alpha or interferon-gamma via iron-dependent pathways.	Iron	228-232	tumor necrosis factor	Homo sapiens	176-203
14597854-2	2003	Changes in iron availability can affect an important regulator of vascular tone, the endothelial nitric oxide synthase (eNOS), activated by a heme-dependent dimerization.	Iron	11-15	nitric oxide synthase 3	Homo sapiens	85-118
14597854-2	2003	Changes in iron availability can affect an important regulator of vascular tone, the endothelial nitric oxide synthase (eNOS), activated by a heme-dependent dimerization.	Iron	11-15	nitric oxide synthase 3	Homo sapiens	120-124
14597854-3	2003	OBJECTIVE: To study the regulation of the anti-hypertensive eNOS in human endothelial cells, in correlation with iron metabolism alterations and stimuli triggering them in vivo, such as inflammation or infection.	Iron	113-117	nitric oxide synthase 3	Homo sapiens	60-64
14597854-10	2003	CONCLUSIONS: The results of this study suggest a down-regulating effect of infectious and inflammatory stimuli on eNOS expression, both at the mRNA level and protein expression or stability and dimerization, enhanced by heme and iron shortage, and indicate eNOS as a possible link between infection and hypertension.	Iron	229-233	nitric oxide synthase 3	Homo sapiens	114-118
14708625-2	2003	In this study, we determined that the generation of interferon regulatory factor-1 expression in human dermal microvascular endothelial cells was transcriptionally mediated by tumor necrosis factor-alpha or interferon-gamma via iron-dependent pathways.	Iron	228-232	interferon gamma	Homo sapiens	207-223
14708625-3	2003	The induction of interferon regulatory factor-1 protein and the up-regulation of interferon regulatory factor-1 mRNA levels was inhibited when cells were pretreated with the iron chelators 2-2-dipyridyl or deferoxamine.	Iron	174-178	interferon regulatory factor 1	Homo sapiens	17-47
14708625-0	2003	Induction of interferon regulatory factor 1 expression in human dermal endothelial cells by interferon-gamma and tumor necrosis factor-alpha is transcriptionally regulated and requires iron.	Iron	185-189	interferon gamma	Homo sapiens	92-140
14708625-3	2003	The induction of interferon regulatory factor-1 protein and the up-regulation of interferon regulatory factor-1 mRNA levels was inhibited when cells were pretreated with the iron chelators 2-2-dipyridyl or deferoxamine.	Iron	174-178	interferon regulatory factor 1	Homo sapiens	81-111
14708625-6	2003	Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription.	Iron	213-217	tumor necrosis factor	Homo sapiens	5-32
14708625-6	2003	Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription.	Iron	213-217	interferon gamma	Homo sapiens	37-53
14708625-6	2003	Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription.	Iron	213-217	interferon regulatory factor 1	Homo sapiens	62-92
14708625-6	2003	Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription.	Iron	213-217	tumor necrosis factor	Homo sapiens	236-263
14708625-6	2003	Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription.	Iron	213-217	interferon gamma	Homo sapiens	267-283
14708625-6	2003	Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription.	Iron	213-217	interferon regulatory factor 1	Homo sapiens	293-323
14708635-0	2003	Inhibition of vascular cell adhesion molecule-1 expression in human dermal microvascular endothelial cells by iron chelators.	Iron	110-114	vascular cell adhesion molecule 1	Homo sapiens	14-47
14567694-5	2003	The striking finding is that the rates of iron release at the pH of the endosome to which transferrin is internalized by the iron-dependent cell are similar in the free proteins but 18 times faster from full-length monoferric transferrin selectively loaded with iron in the C-lobe than from isolated C-lobe when each is complexed to the receptor.	Iron	125-129	transferrin	Homo sapiens	90-101
14568385-1	2003	Lactoferrin is a member of the transferrin family of iron-binding proteins.	Iron	53-57	transferrin	Homo sapiens	31-42
14607997-2	2003	In recent years, the treatment of anaemia of end-stage renal disease with recombinant human erythropoietin (epoetin) has been optimized by adequate iron supply.	Iron	148-152	erythropoietin	Homo sapiens	92-106
14607997-2	2003	In recent years, the treatment of anaemia of end-stage renal disease with recombinant human erythropoietin (epoetin) has been optimized by adequate iron supply.	Iron	148-152	erythropoietin	Homo sapiens	108-115
14607997-3	2003	Intravenous therapy with dextran-free iron compounds has become the ideal and necessary companion of epoetin therapy.	Iron	38-42	erythropoietin	Homo sapiens	101-108
14607997-9	2003	iron could be a "two-edged sword", i.e. on the one hand, it optimizes epoetin therapy, while on the other, it puts the patient at greater risk of other complications.	Iron	0-4	erythropoietin	Homo sapiens	70-77
14607997-11	2003	therapy with dextran-free iron compounds, such as iron sucrose, optimizes epoetin therapy with no direct evidence of any short-term or long-term complications.	Iron	26-30	erythropoietin	Homo sapiens	74-81
21166232-4	2003	RESULTS: As compared with the corresponding sedentary groups, plasma iron and transferrin-iron saturation of three exercise groups were decreased without significant changes of blood hemoglobin and hematocrit.	Iron	90-94	transferrin	Rattus norvegicus	78-89
14567694-0	2003	Iron release from transferrin, its C-lobe, and their complexes with transferrin receptor: presence of N-lobe accelerates release from C-lobe at endosomal pH.	Iron	0-4	transferrin	Homo sapiens	18-29
14567694-0	2003	Iron release from transferrin, its C-lobe, and their complexes with transferrin receptor: presence of N-lobe accelerates release from C-lobe at endosomal pH.	Iron	0-4	transferrin	Homo sapiens	68-79
14567694-1	2003	Human transferrin, like other members of the transferrin class of iron-binding proteins, is a bilobal structure, the product of duplication and fusion of an ancestral gene during the course of biochemical evolution.	Iron	66-70	transferrin	Homo sapiens	6-17
14567694-1	2003	Human transferrin, like other members of the transferrin class of iron-binding proteins, is a bilobal structure, the product of duplication and fusion of an ancestral gene during the course of biochemical evolution.	Iron	66-70	transferrin	Homo sapiens	45-56
14531776-8	2003	Small studies have shown that when heme-iron is administered, less parenteral iron and lower doses of erythropoietin (EPO) are needed to maintain target hemoglobin.	Iron	40-44	erythropoietin	Homo sapiens	102-116
14531776-8	2003	Small studies have shown that when heme-iron is administered, less parenteral iron and lower doses of erythropoietin (EPO) are needed to maintain target hemoglobin.	Iron	40-44	erythropoietin	Homo sapiens	118-121
14592787-0	2003	Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1alpha.	Iron	47-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-123
14592787-3	2003	HIF-1alpha, which functions physiologically as a detector of both hypoxia and iron-deficiency, promotes synthesis of erythropoietin, and may also mediate the up-regulatory impact of hypoxia on intestinal iron absorption.	Iron	78-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
14592787-5	2003	Conversely, the activation of HIF-1alpha associated with iron deficiency may be responsible for the increased glucose tolerance noted in iron-deficient animals; HIF-1alpha promotes efficient glucose uptake and glycolysis - a sensible adaptation to hypoxia - by inducing increased synthesis of glucose transporters and glycolytic enzymes.	Iron	57-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-40
14592787-9	2003	Thus, iron excess may mediate at least some of the increased cancer risk associated with insulin resistance and heme-rich diets.	Iron	6-10	insulin	Homo sapiens	89-96
14592787-10	2003	People who are insulin resistant can minimize any health risk associated with iron overload by avoiding heme-rich flesh foods and donating blood regularly.	Iron	78-82	insulin	Homo sapiens	15-22
14567694-2	2003	Although the two lobes exhibit 45% sequence identity and identical ligand structures of their iron-binding sites (one in each lobe), they differ in their iron-binding properties and their responsiveness to complex formation with the transferrin receptor.	Iron	94-98	transferrin	Homo sapiens	233-244
14567694-2	2003	Although the two lobes exhibit 45% sequence identity and identical ligand structures of their iron-binding sites (one in each lobe), they differ in their iron-binding properties and their responsiveness to complex formation with the transferrin receptor.	Iron	154-158	transferrin	Homo sapiens	233-244
14567694-5	2003	The striking finding is that the rates of iron release at the pH of the endosome to which transferrin is internalized by the iron-dependent cell are similar in the free proteins but 18 times faster from full-length monoferric transferrin selectively loaded with iron in the C-lobe than from isolated C-lobe when each is complexed to the receptor.	Iron	42-46	transferrin	Homo sapiens	90-101
14567694-5	2003	The striking finding is that the rates of iron release at the pH of the endosome to which transferrin is internalized by the iron-dependent cell are similar in the free proteins but 18 times faster from full-length monoferric transferrin selectively loaded with iron in the C-lobe than from isolated C-lobe when each is complexed to the receptor.	Iron	42-46	transferrin	Homo sapiens	226-237
14567694-5	2003	The striking finding is that the rates of iron release at the pH of the endosome to which transferrin is internalized by the iron-dependent cell are similar in the free proteins but 18 times faster from full-length monoferric transferrin selectively loaded with iron in the C-lobe than from isolated C-lobe when each is complexed to the receptor.	Iron	125-129	transferrin	Homo sapiens	90-101
14567694-5	2003	The striking finding is that the rates of iron release at the pH of the endosome to which transferrin is internalized by the iron-dependent cell are similar in the free proteins but 18 times faster from full-length monoferric transferrin selectively loaded with iron in the C-lobe than from isolated C-lobe when each is complexed to the receptor.	Iron	125-129	transferrin	Homo sapiens	226-237
14567694-5	2003	The striking finding is that the rates of iron release at the pH of the endosome to which transferrin is internalized by the iron-dependent cell are similar in the free proteins but 18 times faster from full-length monoferric transferrin selectively loaded with iron in the C-lobe than from isolated C-lobe when each is complexed to the receptor.	Iron	125-129	transferrin	Homo sapiens	226-237
12966575-1	2003	The iron storage protein, apoferritin, has a cavity in which iron is oxidized and stored as a hydrated oxide core.	Iron	4-8	ferritin heavy chain	Equus caballus	26-37
12966575-1	2003	The iron storage protein, apoferritin, has a cavity in which iron is oxidized and stored as a hydrated oxide core.	Iron	61-65	ferritin heavy chain	Equus caballus	26-37
12902335-0	2003	A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions.	Iron	77-81	Fe(2+) transporter	Saccharomyces cerevisiae S288C	52-59
12902335-0	2003	A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions.	Iron	100-104	Fe(2+) transporter	Saccharomyces cerevisiae S288C	52-59
12902335-2	2003	To elucidate their function we utilized genome-wide expression profiling and found that both deletion and overexpression of MRS3/4 lead to up-regulation of several genes of the "iron regulon."	Iron	178-182	Fe(2+) transporter	Saccharomyces cerevisiae S288C	124-130
12902335-4	2003	Radiolabeling of yeast cells with 55Fe revealed a clear correlation between MRS3/4 expression levels and the efficiency of these biosynthetic reactions indicating a role of the carriers in utilization and/or transport of iron in vivo.	Iron	221-225	Fe(2+) transporter	Saccharomyces cerevisiae S288C	76-82
12902335-6	2003	The correlation between MRS3/4 expression levels and the efficiency of the two iron-utilizing processes was lost upon detergent lysis of mitochondria.	Iron	79-83	Fe(2+) transporter	Saccharomyces cerevisiae S288C	24-30
12902335-7	2003	As no significant changes in the mitochondrial membrane potential were observed upon overexpression or deletion of MRS3/4, our results suggest that Mrs3/4p carriers are directly involved in mitochondrial iron uptake.	Iron	204-208	Fe(2+) transporter	Saccharomyces cerevisiae S288C	115-121
12902335-7	2003	As no significant changes in the mitochondrial membrane potential were observed upon overexpression or deletion of MRS3/4, our results suggest that Mrs3/4p carriers are directly involved in mitochondrial iron uptake.	Iron	204-208	Fe(2+) transporter	Saccharomyces cerevisiae S288C	148-155
12902335-8	2003	Mrs3/4p function in mitochondrial iron transport becomes evident under iron-limiting conditions only, indicating that the two carriers do not represent the sole system for mitochondrial iron acquisition.	Iron	34-38	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-7
12902335-8	2003	Mrs3/4p function in mitochondrial iron transport becomes evident under iron-limiting conditions only, indicating that the two carriers do not represent the sole system for mitochondrial iron acquisition.	Iron	71-75	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-7
12902335-8	2003	Mrs3/4p function in mitochondrial iron transport becomes evident under iron-limiting conditions only, indicating that the two carriers do not represent the sole system for mitochondrial iron acquisition.	Iron	71-75	Fe(2+) transporter	Saccharomyces cerevisiae S288C	0-7
14520627-6	2003	The MIS and serum concentrations of high-sensitivity C-reactive protein, interleukin 6 (IL-6), tumor necrosis factor-alpha, and lactate dehydrogenase had positive correlation with required EPO dose and EPO responsiveness index (EPO divided by hemoglobin), whereas serum total iron binding capacity (TIBC), prealbumin and total cholesterol, as well as blood lymphocyte count had statistically significant but negative correlations with indices of refractory anemia.	Iron	276-280	C-reactive protein	Homo sapiens	53-71
12888568-0	2003	Oxygen and iron regulation of iron regulatory protein 2.	Iron	11-15	iron responsive element binding protein 2	Homo sapiens	30-55
12888568-1	2003	Iron regulatory protein 2 (IRP2) is a central regulator of cellular iron homeostasis due to its regulation of specific mRNAs encoding proteins of iron uptake and storage.	Iron	68-72	iron responsive element binding protein 2	Homo sapiens	0-25
12888568-1	2003	Iron regulatory protein 2 (IRP2) is a central regulator of cellular iron homeostasis due to its regulation of specific mRNAs encoding proteins of iron uptake and storage.	Iron	68-72	iron responsive element binding protein 2	Homo sapiens	27-31
12888568-1	2003	Iron regulatory protein 2 (IRP2) is a central regulator of cellular iron homeostasis due to its regulation of specific mRNAs encoding proteins of iron uptake and storage.	Iron	146-150	iron responsive element binding protein 2	Homo sapiens	0-25
12888568-1	2003	Iron regulatory protein 2 (IRP2) is a central regulator of cellular iron homeostasis due to its regulation of specific mRNAs encoding proteins of iron uptake and storage.	Iron	146-150	iron responsive element binding protein 2	Homo sapiens	27-31
12888568-2	2003	Iron regulates IRP2 by mediating its rapid proteasomal degradation, where hypoxia and the hypoxia mimetics CoCl2 and desferrioxamine (DFO) stabilize it.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	15-19
12888568-3	2003	Previous studies showed that iron-mediated degradation of IRP2 requires the presence of critical cysteines that reside within a 73-amino acid unique region.	Iron	29-33	iron responsive element binding protein 2	Homo sapiens	58-62
12888568-7	2003	Since 2-OG-dependent dioxygenases require iron and oxygen, in addition to 2-OG, for substrate hydroxylation, we hypothesized that this activity may be involved in the regulation of IRP2 stability.	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	181-185
12888568-8	2003	To test this we used the 2-OG-dependent dioxygenase inhibitor dimethyloxalylglycine (DMOG) and showed that it blocked iron-mediated IRP2 degradation.	Iron	118-122	iron responsive element binding protein 2	Homo sapiens	132-136
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	39-43
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	64-68
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	64-68
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Iron	241-245	iron responsive element binding protein 2	Homo sapiens	39-43
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Iron	241-245	iron responsive element binding protein 2	Homo sapiens	64-68
12888568-10	2003	These data indicate that the region of IRP2 that is involved in IRP2 iron-mediated degradation lies outside of the 73-amino acid unique region and suggest a model whereby 2-OG-dependent dioxygenase activity may be involved in the oxygen and iron regulation of IRP2 protein stability.	Iron	241-245	iron responsive element binding protein 2	Homo sapiens	64-68
14560047-4	2003	The system is based on the iron-responsive element, which regulates the translation of both endogenous ferritin and transferrin transcripts in response to changes in iron concentration.	Iron	27-31	transferrin	Homo sapiens	116-127
14560047-4	2003	The system is based on the iron-responsive element, which regulates the translation of both endogenous ferritin and transferrin transcripts in response to changes in iron concentration.	Iron	166-170	transferrin	Homo sapiens	116-127
14516743-3	2003	Endonuclease I is active in the presence of magnesium, manganese, iron (II) and cobalt (II) ions, weakly active in the presence of nickel, copper (II) and zinc ions, and completely inactive in the presence of calcium ions.	Iron	66-70	endonuclease I	Escherichia phage T7	0-14
14516743-5	2003	In the presence of iron (II) ions, we have obtained a cleavage of the continuous strands of a junction bound by endonuclease I, at sites close to (but not identical with) enzyme-induced hydrolysis.	Iron	19-23	endonuclease I	Escherichia phage T7	112-126
14520627-6	2003	The MIS and serum concentrations of high-sensitivity C-reactive protein, interleukin 6 (IL-6), tumor necrosis factor-alpha, and lactate dehydrogenase had positive correlation with required EPO dose and EPO responsiveness index (EPO divided by hemoglobin), whereas serum total iron binding capacity (TIBC), prealbumin and total cholesterol, as well as blood lymphocyte count had statistically significant but negative correlations with indices of refractory anemia.	Iron	276-280	erythropoietin	Homo sapiens	189-192
14520627-6	2003	The MIS and serum concentrations of high-sensitivity C-reactive protein, interleukin 6 (IL-6), tumor necrosis factor-alpha, and lactate dehydrogenase had positive correlation with required EPO dose and EPO responsiveness index (EPO divided by hemoglobin), whereas serum total iron binding capacity (TIBC), prealbumin and total cholesterol, as well as blood lymphocyte count had statistically significant but negative correlations with indices of refractory anemia.	Iron	276-280	erythropoietin	Homo sapiens	202-205
14520627-6	2003	The MIS and serum concentrations of high-sensitivity C-reactive protein, interleukin 6 (IL-6), tumor necrosis factor-alpha, and lactate dehydrogenase had positive correlation with required EPO dose and EPO responsiveness index (EPO divided by hemoglobin), whereas serum total iron binding capacity (TIBC), prealbumin and total cholesterol, as well as blood lymphocyte count had statistically significant but negative correlations with indices of refractory anemia.	Iron	276-280	erythropoietin	Homo sapiens	202-205
12805056-1	2003	Plasma non-transferrin-bound-iron (NTBI) is believed to be responsible for catalyzing the formation of reactive radicals in the circulation of iron overloaded subjects, resulting in accumulation of oxidation products.	Iron	29-33	transferrin	Homo sapiens	11-22
12805056-1	2003	Plasma non-transferrin-bound-iron (NTBI) is believed to be responsible for catalyzing the formation of reactive radicals in the circulation of iron overloaded subjects, resulting in accumulation of oxidation products.	Iron	143-147	transferrin	Homo sapiens	11-22
14512878-1	2003	Heme oxygenase-1 (HO-1), a stress-responsive enzyme that catabolizes heme into carbon monoxide (CO), biliverdin, and iron, has previously been shown to protect grafts from ischemia/reperfusion injury and rejection.	Iron	117-121	heme oxygenase 1	Mus musculus	0-16
12869419-0	2003	The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1.	Iron	21-25	tumor protein p53	Homo sapiens	57-60
12869419-0	2003	The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1.	Iron	21-25	tumor protein p53	Homo sapiens	134-137
12869419-0	2003	The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1.	Iron	21-25	cyclin dependent kinase inhibitor 1A	Homo sapiens	165-169
12869419-10	2003	Our experiments demonstrated: (i) that the elevated WAF1 mRNA expression after Fe chelation was due to increased transcription and also to a post-transcriptional mechanism that was sensitive to cycloheximide; and (ii) that Fe-chelation increased WAF1 expression through a p53-independent pathway.	Iron	79-81	cyclin dependent kinase inhibitor 1A	Homo sapiens	52-56
12869419-10	2003	Our experiments demonstrated: (i) that the elevated WAF1 mRNA expression after Fe chelation was due to increased transcription and also to a post-transcriptional mechanism that was sensitive to cycloheximide; and (ii) that Fe-chelation increased WAF1 expression through a p53-independent pathway.	Iron	79-81	cyclin dependent kinase inhibitor 1A	Homo sapiens	246-250
12869419-10	2003	Our experiments demonstrated: (i) that the elevated WAF1 mRNA expression after Fe chelation was due to increased transcription and also to a post-transcriptional mechanism that was sensitive to cycloheximide; and (ii) that Fe-chelation increased WAF1 expression through a p53-independent pathway.	Iron	79-81	tumor protein p53	Homo sapiens	272-275
14500582-6	2003	The ratio of serum transferrin receptor (sTfR) to serum ferritin (R/F ratio) has been shown to have excellent performance in estimating body iron stores, but it cannot be used widely because of the lack of standardization for sTfR assays.	Iron	141-145	transferrin	Homo sapiens	19-30
14512884-0	2003	Effects of cell proliferation on the uptake of transferrin-bound iron by human hepatoma cells.	Iron	65-69	transferrin	Homo sapiens	47-58
14512884-1	2003	The effects of cellular proliferation on the uptake of transferrin-bound iron (Tf-Fe) and expression of transferrin receptor-1 (TfR1) and transferrin receptor-2 (TfR2) were investigated using a human hepatoma (HuH7) cell line stably transfected with TfR1 antisense RNA expression vector to suppress TfR1 expression.	Iron	73-77	transferrin	Homo sapiens	55-66
14512884-2	2003	At transferrin (Tf) concentrations of 50 nmol/L and 5 micromol/L, when Tf-Fe uptake occurs by the TfR1- and TfR1-independent (NTfR1)-mediated process, respectively, the rate of Fe uptake by proliferating cells was approximately 250% that of stationary cells.	Iron	74-76	transferrin	Homo sapiens	3-14
14703796-2	2003	One of the most important mechanisms of antioxidant defense is thus the sequestration of iron in a redox-inactive form by transferrin.	Iron	89-93	transferrin	Homo sapiens	122-133
14703796-9	2003	Colorimetric evaluation of total iron binding capacity in the presence of an excess of iron (iron/transferrin molar ratio = 2.4) also decreased from 0.726 to 0.696 and 0.585mg/g transferrin after 0, 5.6 and 33.3 mmol/l glucose, respectively, p &lt; 0.01.	Iron	33-37	transferrin	Homo sapiens	98-109
14703796-9	2003	Colorimetric evaluation of total iron binding capacity in the presence of an excess of iron (iron/transferrin molar ratio = 2.4) also decreased from 0.726 to 0.696 and 0.585mg/g transferrin after 0, 5.6 and 33.3 mmol/l glucose, respectively, p &lt; 0.01.	Iron	33-37	transferrin	Homo sapiens	178-189
14703796-9	2003	Colorimetric evaluation of total iron binding capacity in the presence of an excess of iron (iron/transferrin molar ratio = 2.4) also decreased from 0.726 to 0.696 and 0.585mg/g transferrin after 0, 5.6 and 33.3 mmol/l glucose, respectively, p &lt; 0.01.	Iron	87-91	transferrin	Homo sapiens	98-109
14703796-9	2003	Colorimetric evaluation of total iron binding capacity in the presence of an excess of iron (iron/transferrin molar ratio = 2.4) also decreased from 0.726 to 0.696 and 0.585mg/g transferrin after 0, 5.6 and 33.3 mmol/l glucose, respectively, p &lt; 0.01.	Iron	87-91	transferrin	Homo sapiens	178-189
14703796-9	2003	Colorimetric evaluation of total iron binding capacity in the presence of an excess of iron (iron/transferrin molar ratio = 2.4) also decreased from 0.726 to 0.696 and 0.585mg/g transferrin after 0, 5.6 and 33.3 mmol/l glucose, respectively, p &lt; 0.01.	Iron	87-91	transferrin	Homo sapiens	98-109
14703796-9	2003	Colorimetric evaluation of total iron binding capacity in the presence of an excess of iron (iron/transferrin molar ratio = 2.4) also decreased from 0.726 to 0.696 and 0.585mg/g transferrin after 0, 5.6 and 33.3 mmol/l glucose, respectively, p &lt; 0.01.	Iron	87-91	transferrin	Homo sapiens	178-189
14703796-10	2003	In conclusion, these results suggest that lower transferrin concentration and its glycation can, by enhancing the pro-oxidant effects of iron, contribute to the increased lipid peroxidation observed in diabetes.	Iron	137-141	transferrin	Homo sapiens	48-59
14703801-10	2003	The AA promoted damage to apoferritin produced a 40% decrease in apoprotein ferroxidase activity and an 80% decrease in its iron uptake ability.	Iron	124-128	ferritin heavy chain	Equus caballus	26-37
14703801-11	2003	The current findings of changes in ferritin and apoferritin may contribute to intracellular iron-induced oxidative stress during AA formation in ketosis and diabetes mellitus.	Iron	92-96	ferritin heavy chain	Equus caballus	48-59
14512878-1	2003	Heme oxygenase-1 (HO-1), a stress-responsive enzyme that catabolizes heme into carbon monoxide (CO), biliverdin, and iron, has previously been shown to protect grafts from ischemia/reperfusion injury and rejection.	Iron	117-121	heme oxygenase 1	Mus musculus	18-22
15025343-1	2003	Prevalence of iron deficiency in anemia of chronic renal failure (CRF) has long been the subject of interest, because the patients of CRF with coexistent iron deficiency anemia need to be treated with iron preparations before starting erythropoietin therapy.	Iron	14-18	erythropoietin	Homo sapiens	235-249
12927366-6	2003	Levels in HSC of mRNA for collagen type I, collagen type IV, TGF-beta, and plasminogen activator inhibitor-1 were unaffected by exposure to CM but increased significantly when CM from iron-loaded hepatocytes was heat-treated.	Iron	184-188	serpin family E member 1	Rattus norvegicus	75-108
14505344-9	2003	IL-10 levels negatively correlated with indicators of iron status (r &lt;or= -0.285) and lymphocyte proliferation (r &lt;or= -0.379 [r &lt;or= -0.743 for ID mice]), but positively correlated with IFN-gamma levels (r &lt;or= 0.47; P &lt; 0.05).	Iron	54-58	interleukin 10	Mus musculus	0-5
14505344-11	2003	Reduced IL-10 secretion by activated cells does not overcome the inhibition of lymphocyte proliferation due to other factors of T cell activation that are regulated by iron.	Iron	168-172	interleukin 10	Mus musculus	8-13
13679021-0	2003	Turning an "Achilles" Heel" into an asset--activation of HIF-1alpha during angiostatic therapy will increase tumor sensitivity to iron-catalyzed oxidative damage.	Iron	130-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
13679021-4	2003	The natural antimalarial drug artemisinin is selectively toxic to iron-loaded cells (such as malarial parasites), and it has recently been suggested that, inasmuch as many cancers overexpress transferrin receptors, such cancers might be treatable with a regimen comprised of iron supplementation and high-dose artemisinin.	Iron	66-70	transferrin	Homo sapiens	192-203
13679021-4	2003	The natural antimalarial drug artemisinin is selectively toxic to iron-loaded cells (such as malarial parasites), and it has recently been suggested that, inasmuch as many cancers overexpress transferrin receptors, such cancers might be treatable with a regimen comprised of iron supplementation and high-dose artemisinin.	Iron	275-279	transferrin	Homo sapiens	192-203
12927366-7	2003	In HepG2 cell cultures, iron loading increased total (but not activated) TGF-beta secretion into the medium approximately 2-fold.	Iron	24-28	transforming growth factor beta 1	Homo sapiens	73-81
12927366-8	2003	We conclude that increased secretion of latent TGF-beta by hepatocytes injured by iron is a potential factor influencing fibrogenic behavior of HSC.	Iron	82-86	transforming growth factor, beta 1	Rattus norvegicus	47-55
12970193-3	2003	Depletion of the cysteine desulfurase Nfs1p, the ferredoxin Yah1p or the yeast frataxin homologue Yfh1p by regulated gene expression causes a strong decrease in the de novo synthesis of Fe/S clusters on Isu1p.	Iron	186-188	cysteine desulfurase	Saccharomyces cerevisiae S288C	38-43
12958216-3	2003	H2O2-mediated intracellular dichlorofluorescein fluorescence and apoptosis were enhanced by the transferrin receptor (TfR)-mediated iron uptake.	Iron	132-136	transferrin receptor	Bos taurus	96-116
12958216-3	2003	H2O2-mediated intracellular dichlorofluorescein fluorescence and apoptosis were enhanced by the transferrin receptor (TfR)-mediated iron uptake.	Iron	132-136	transferrin receptor	Bos taurus	118-121
12958216-4	2003	*NO inhibited the TfR-mediated iron uptake, dichlorofluorescein fluorescence, and apoptosis in H2O2-treated cells.	Iron	31-35	transferrin receptor	Bos taurus	18-21
12958216-7	2003	*NO, by activating proteolysis, mitigates TfR-dependent iron uptake, dichlorodihydrofluorescein oxidation, and apoptosis in H2O2-treated bovine aortic endothelial cells.	Iron	56-60	transferrin receptor	Bos taurus	42-45
12971756-1	2003	The exchange of Fe(3+), Tb(3+), In(3+), Ga(3+), and Al(3+) between the C-terminal metal-binding site of the serum iron transport protein transferrin and the low-molecular-mass serum chelating agent citrate has been studied at pH 7.4 and 25 degrees C. The removal of Ga(3+), In(3+), and Al(3+) follows simple saturation kinetics with respect to the citrate concentration.	Iron	16-18	transferrin	Homo sapiens	137-148
12971756-1	2003	The exchange of Fe(3+), Tb(3+), In(3+), Ga(3+), and Al(3+) between the C-terminal metal-binding site of the serum iron transport protein transferrin and the low-molecular-mass serum chelating agent citrate has been studied at pH 7.4 and 25 degrees C. The removal of Ga(3+), In(3+), and Al(3+) follows simple saturation kinetics with respect to the citrate concentration.	Iron	114-118	transferrin	Homo sapiens	137-148
12971756-7	2003	It is suggested that protein interactions across the interdomain cleft of transferrin largely control the release of the first group of metal ions, while the breaking of stronger metal-protein bonds slows the rate of iron release.	Iron	217-221	transferrin	Homo sapiens	74-85
12970193-4	2003	In contrast, depletion of the Hsp70 chaperone Ssq1p, its co-chaperone Jac1p or the glutaredoxin Grx5p markedly increased the amount of Fe/S clusters bound to Isu1p, even though these mitochondrial proteins are crucial for maturation of Fe/S proteins.	Iron	135-137	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	46-51
12970193-4	2003	In contrast, depletion of the Hsp70 chaperone Ssq1p, its co-chaperone Jac1p or the glutaredoxin Grx5p markedly increased the amount of Fe/S clusters bound to Isu1p, even though these mitochondrial proteins are crucial for maturation of Fe/S proteins.	Iron	135-137	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	96-101
12813050-5	2003	PLA2 activity assessed by release of preloaded [3H]AA after treatment with AA+Fe was higher in the CYP2E1 expressing HepG2 cells.	Iron	78-80	phospholipase A2 group IB	Homo sapiens	0-4
12965205-0	2003	Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat.	Iron	0-4	angiotensinogen	Rattus norvegicus	53-67
12965205-1	2003	Administration of angiotensin II to rats decreases renal expression of klotho, an aging-related gene, and also causes abnormal iron deposition in renal cells.	Iron	127-131	angiotensinogen	Rattus norvegicus	18-32
12965205-3	2003	Administration of iron-dextran caused a downregulation of klotho expression, and iron chelation suppressed the angiotensin II-induced downregulation of this gene.	Iron	18-22	angiotensinogen	Rattus norvegicus	111-125
12965205-5	2003	Collectively, these findings suggest that abnormal iron metabolism and increased oxidative stress are involved in the mechanism of angiotensin II-mediated modulation of klotho expression.	Iron	51-55	angiotensinogen	Rattus norvegicus	131-145
12813050-8	2003	PLA2 inhibitors also blocked mitochondrial damage in the CYP2E1-expressing HepG2 cells exposed to AA+Fe.	Iron	101-103	phospholipase A2 group IB	Homo sapiens	0-4
12813050-8	2003	PLA2 inhibitors also blocked mitochondrial damage in the CYP2E1-expressing HepG2 cells exposed to AA+Fe.	Iron	101-103	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	57-63
12813050-5	2003	PLA2 activity assessed by release of preloaded [3H]AA after treatment with AA+Fe was higher in the CYP2E1 expressing HepG2 cells.	Iron	78-80	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	99-105
12813050-12	2003	These results suggest that release of stored calcium by AA+Fe, induced by lipid peroxidation, can initially activate calpain and PLA2 activity, that PLA2 activation is critical for a subsequent increased influx of extracellular Ca2+, and that the combination of increased PLA2 and calpain activity, increased calcium and oxidative stress cause mitochondrial damage, that ultimately produces the rapid toxicity of AA+Fe in CYP2E1-expressing HepG2 cells.	Iron	59-61	phospholipase A2 group IB	Homo sapiens	129-133
12813050-12	2003	These results suggest that release of stored calcium by AA+Fe, induced by lipid peroxidation, can initially activate calpain and PLA2 activity, that PLA2 activation is critical for a subsequent increased influx of extracellular Ca2+, and that the combination of increased PLA2 and calpain activity, increased calcium and oxidative stress cause mitochondrial damage, that ultimately produces the rapid toxicity of AA+Fe in CYP2E1-expressing HepG2 cells.	Iron	59-61	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	422-428
12959597-4	2003	The binding of cyt c to negatively charged SPS particles causes an extensive disruption of the native compact structure of cyt c: the cleavage of Fe-Met80 ligand, about 40% loss of the helical structure, and the disruption of the asymmetry environment of Trp59.	Iron	146-148	cytochrome c, somatic	Homo sapiens	15-20
12914965-7	2003	Both isoforms of apoE stimulated formation of apoE-Abeta deposits and increased immobilization of iron in cultures treated with ferrous ions.	Iron	98-102	apolipoprotein E	Homo sapiens	17-21
12680706-6	2003	Catalase was found to reduce the effect of iron on the enzyme dependent ascorbate oxidation, strongly suggesting that H2O2, produced during catalysis, is involved in the oxidation of ferrous ions.	Iron	43-47	catalase	Homo sapiens	0-8
14499930-6	2003	In contrast, the heme group is not destroyed during glycation of cytochrome c, where the sixth coordination position of the heme iron is not accessible to solvent ligands.	Iron	129-133	cytochrome c, somatic	Homo sapiens	65-77
12959597-4	2003	The binding of cyt c to negatively charged SPS particles causes an extensive disruption of the native compact structure of cyt c: the cleavage of Fe-Met80 ligand, about 40% loss of the helical structure, and the disruption of the asymmetry environment of Trp59.	Iron	146-148	cytochrome c, somatic	Homo sapiens	123-128
12947415-4	2003	Association between Yfh1 and Isu1/Nfs1 was markedly increased by ferrous iron, but did not depend on ISCs on Isu1.	Iron	73-77	cysteine desulfurase	Saccharomyces cerevisiae S288C	34-38
14527082-6	2003	CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide, and in the presence of iron catalysts, produces powerful oxidants such as the hydroxyl radical.	Iron	148-152	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
12730111-5	2003	Both iron-deficient wild-type mice and sla mice showed increased expression of Heph and Ireg1 mRNA, compared to controls, whereas only iron-deficient wild-type mice had increased expression of the brush border transporter Dmt1.	Iron	5-9	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	88-93
12972033-0	2003	The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.	Iron	83-87	iron responsive element binding protein 2	Homo sapiens	113-117
12972033-1	2003	Iron regulatory protein 2 (IRP2) is a mammalian cytosolic iron-sensing protein that regulates expression of iron metabolism proteins, including ferritin and transferrin receptor 1.	Iron	58-62	iron responsive element binding protein 2	Homo sapiens	0-25
12972033-1	2003	Iron regulatory protein 2 (IRP2) is a mammalian cytosolic iron-sensing protein that regulates expression of iron metabolism proteins, including ferritin and transferrin receptor 1.	Iron	58-62	iron responsive element binding protein 2	Homo sapiens	27-31
12972033-1	2003	Iron regulatory protein 2 (IRP2) is a mammalian cytosolic iron-sensing protein that regulates expression of iron metabolism proteins, including ferritin and transferrin receptor 1.	Iron	108-112	iron responsive element binding protein 2	Homo sapiens	0-25
12972033-1	2003	Iron regulatory protein 2 (IRP2) is a mammalian cytosolic iron-sensing protein that regulates expression of iron metabolism proteins, including ferritin and transferrin receptor 1.	Iron	108-112	iron responsive element binding protein 2	Homo sapiens	27-31
12972033-2	2003	IRP2 is ubiquitinated and degraded by the proteasome in iron-replete cells but is relatively stable in iron-depleted cells.	Iron	56-60	iron responsive element binding protein 2	Homo sapiens	0-4
12972033-2	2003	IRP2 is ubiquitinated and degraded by the proteasome in iron-replete cells but is relatively stable in iron-depleted cells.	Iron	103-107	iron responsive element binding protein 2	Homo sapiens	0-4
12972033-3	2003	Recent work has shown that IRP2 contains a unique 73-amino-acid domain that binds iron in vitro and undergoes iron-dependent oxidation and cleavage (J. Biol.	Iron	82-86	iron responsive element binding protein 2	Homo sapiens	27-31
12972033-3	2003	Recent work has shown that IRP2 contains a unique 73-amino-acid domain that binds iron in vitro and undergoes iron-dependent oxidation and cleavage (J. Biol.	Iron	110-114	iron responsive element binding protein 2	Homo sapiens	27-31
12972033-7	2003	To assess the role of these cysteines in cellular iron- dependent degradation of IRP2, we mutagenized these cysteines in various combinations in the context of full-length protein and generated cell lines in which recombinant IRP2 expression was inducible.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	81-85
12972033-8	2003	Iron-dependent degradation of IRP2 mutagenized at any or all of the cysteines of the putative degradation domain in cells was comparable to wild-type (WT).	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	30-34
12972033-11	2003	Inhibition of endogenous heme synthesis with succinylacetone significantly inhibited iron- dependent degradation of IRP2.	Iron	85-89	iron responsive element binding protein 2	Homo sapiens	116-120
12972033-14	2003	The early molecular events in iron-dependent degradation of IRP2 remain to be elucidated.	Iron	30-34	iron responsive element binding protein 2	Homo sapiens	60-64
13129459-15	2003	Serum Fe and Fe saturation of transferrin were significantly higher in both Fe-supplemented groups than the placebo group up to 2 months; this effect, however, disappeared at 6 months.	Iron	13-15	transferrin	Homo sapiens	30-41
13129459-15	2003	Serum Fe and Fe saturation of transferrin were significantly higher in both Fe-supplemented groups than the placebo group up to 2 months; this effect, however, disappeared at 6 months.	Iron	13-15	transferrin	Homo sapiens	30-41
13129459-18	2003	These observations suggest that Fe supplementation in mild to moderate anaemia associated with pulmonary tuberculosis accelerated the normal resumption of haematopoiesis in the initial phases by increasing Fe saturation of transferrin.	Iron	32-34	transferrin	Homo sapiens	223-234
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	4-8	cysteine desulfurase	Saccharomyces cerevisiae S288C	43-47
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	84-88	cysteine desulfurase	Saccharomyces cerevisiae S288C	43-47
12928591-0	2003	Dietary iron restriction increases plaque stability in apolipoprotein-e-deficient mice.	Iron	8-12	apolipoprotein E	Mus musculus	55-71
14666504-4	2003	Use of iron: At the start of epoetin treatment, 150 mg of iron are needed for every expected increase of 1 g/dL of Hb.	Iron	7-11	erythropoietin	Homo sapiens	29-36
14666504-4	2003	Use of iron: At the start of epoetin treatment, 150 mg of iron are needed for every expected increase of 1 g/dL of Hb.	Iron	58-62	erythropoietin	Homo sapiens	29-36
12968678-13	2003	Serum IGF-I correlated with trabecular bone volume (r = 0.6, p = 0.03), inversely with both serum ferritin level (r = -0.6, p &lt; 0.01), and inversely with stainable iron surface (r = -0.53, p = 0.02).	Iron	167-171	insulin like growth factor 1	Homo sapiens	6-11
12928591-9	2003	Together, these data indicate that decreased vascular iron content following dietary iron restriction in ApoE-deficient mice leads to lower matrix degradation capacity and increased plaque stability.	Iron	54-58	apolipoprotein E	Mus musculus	105-109
12928591-9	2003	Together, these data indicate that decreased vascular iron content following dietary iron restriction in ApoE-deficient mice leads to lower matrix degradation capacity and increased plaque stability.	Iron	85-89	apolipoprotein E	Mus musculus	105-109
20019947-1	2003	Early introduction of whole cow"s milk may lead to iron deficiency anemia.	Iron	51-55	Weaning weight-maternal milk	Bos taurus	34-38
14733417-1	2003	BACKGROUND: In patients on hemodialysis (HD), parenteral iron improves the response to recombinant human erythropoietin (rhuEPO) therapy, but in some subjects it produces an iron overload, increasing their morbidity and mortality rates.	Iron	57-61	erythropoietin	Homo sapiens	105-119
12900815-3	2003	Recent work suggests oral heme iron may be an effective supplement for hemodialysis (HD) patients because it is absorbed by patients with high ferritin levels, has fewer side effects, and its absorption is stimulated by erythropoietin administration.	Iron	31-35	erythropoietin	Homo sapiens	220-234
12728319-2	2003	AtFer1, which strongly accumulates in leaves treated with excess iron, contains in its promoter an Iron- Dependent Regulatory Sequence (IDRS).	Iron	65-69	ferretin 1	Arabidopsis thaliana	0-6
12728319-2	2003	AtFer1, which strongly accumulates in leaves treated with excess iron, contains in its promoter an Iron- Dependent Regulatory Sequence (IDRS).	Iron	99-103	ferretin 1	Arabidopsis thaliana	0-6
12728319-3	2003	The IDRS sequence is responsible for repression of AtFer1 transcription under conditions of low iron supply.	Iron	96-100	ferretin 1	Arabidopsis thaliana	51-57
12756240-7	2003	These findings are consistent with the role in Fe/S biogenesis previously proposed for the bacterial Hsp70 Hsc66 and J-protein Hsc20 that interact with the bacterial Isu homologue IscU.	Iron	47-49	iron-sulfur cluster assembly enzyme	Homo sapiens	180-184
12874382-1	2003	The mechanisms by which the hereditary hemochromatosis protein, HFE, decreases transferrin-mediated iron uptake were examined.	Iron	100-104	transferrin	Homo sapiens	79-90
12874382-4	2003	However, cells expressing HFE still showed a decrease in Tf-mediated iron uptake at concentrations of Tf sufficient to dissociate HFE from the TfR.	Iron	69-73	transferrin	Homo sapiens	57-59
14572128-13	2003	Indeed, patients with serum iron concentrations less than 50 microg/dL had a higher PLMI compared to patients with serum iron concentrations greater than 50 microg/dL (42.8 +/- 18.3 PLM/h and 23.1 +/- 10.1 PLM/h, respectively; P = 0.02).	Iron	28-32	FXYD domain containing ion transport regulator 1	Homo sapiens	84-87
14572128-15	2003	Among the responders to iron therapy, PLMI decreased from 27.6 +/- 14.9 PLM per hour to 12.6 +/- 5.3 PLM per hour after 3 months of iron supplements (P &lt; 0.001) and coincided with increases in serum ferritin levels (pre: 40.8 +/- 27.4 microg/L vs post: 74.1 +/- 13.0 microg/L; P &lt; 0.001).	Iron	24-28	FXYD domain containing ion transport regulator 1	Homo sapiens	38-41
14572128-15	2003	Among the responders to iron therapy, PLMI decreased from 27.6 +/- 14.9 PLM per hour to 12.6 +/- 5.3 PLM per hour after 3 months of iron supplements (P &lt; 0.001) and coincided with increases in serum ferritin levels (pre: 40.8 +/- 27.4 microg/L vs post: 74.1 +/- 13.0 microg/L; P &lt; 0.001).	Iron	24-28	FXYD domain containing ion transport regulator 1	Homo sapiens	72-75
14572128-15	2003	Among the responders to iron therapy, PLMI decreased from 27.6 +/- 14.9 PLM per hour to 12.6 +/- 5.3 PLM per hour after 3 months of iron supplements (P &lt; 0.001) and coincided with increases in serum ferritin levels (pre: 40.8 +/- 27.4 microg/L vs post: 74.1 +/- 13.0 microg/L; P &lt; 0.001).	Iron	132-136	FXYD domain containing ion transport regulator 1	Homo sapiens	38-41
12886008-3	2003	In particular, genetic and biochemical studies suggest that IscU, Nfu, and IscA function as scaffold proteins for assembly and delivery of rudimentary Fe-S clusters to target proteins.	Iron	151-155	iron-sulfur cluster assembly enzyme	Homo sapiens	60-64
12886008-9	2003	These results, together with previous reports of subcellular distributions of isoforms of human IscS and IscU in mitochondria, cytosol, and nucleus suggest that the Fe-S cluster assembly machineries are compartmentalized in higher eukaryotes.	Iron	165-169	iron-sulfur cluster assembly enzyme	Homo sapiens	105-109
12885946-7	2003	Thus, iron perturbations regulate IFN-gamma effector pathways by transcriptional and post-transcriptional mechanisms, indicating that iron rather interferes with IFN-gamma signal-transduction processes.	Iron	6-10	interferon gamma	Homo sapiens	34-43
14569300-1	2003	Pathogenic Gram-negative bacteria of the Pasteurellaceae and Neisseriaceae acquire iron for growth from host transferrin through the action of specific surface receptors.	Iron	83-87	transferrin	Homo sapiens	109-120
14569300-2	2003	Iron is removed from transferrin by the receptor at the cell surface and is transported across the outer membrane to the periplasm.	Iron	0-4	transferrin	Homo sapiens	21-32
14515008-3	2003	The pattern of iron loading in African iron overload with saturated transferrin is similar to that seen in hereditary hemochromatosis.	Iron	15-19	transferrin	Homo sapiens	68-79
14515008-3	2003	The pattern of iron loading in African iron overload with saturated transferrin is similar to that seen in hereditary hemochromatosis.	Iron	39-43	transferrin	Homo sapiens	68-79
14515008-8	2003	Iron loading in the subjects with increased transferrin saturation ranged from moderate to severe.	Iron	0-4	transferrin	Homo sapiens	44-55
12966064-7	2003	We have recently identified HOIL-1 (heme-oxidized IRP2 ubiquitin ligase-1) as an E3 ligase that recognizes a protein that has been oxidized by iron.	Iron	143-147	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	28-34
12966064-7	2003	We have recently identified HOIL-1 (heme-oxidized IRP2 ubiquitin ligase-1) as an E3 ligase that recognizes a protein that has been oxidized by iron.	Iron	143-147	RANBP2-type and C3HC4-type zinc finger containing 1	Homo sapiens	36-73
12885946-0	2003	Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells.	Iron	67-71	interferon gamma	Homo sapiens	31-47
12885946-1	2003	To elucidate iron-regulated interferon-gamma (IFN-gamma) effector functions, we investigated three IFN-gamma-inducible genes [intercellular adhesion molecule-1 (ICAM-1), human leukocyte antigen (HLA)-DR, guanosine 5"-triphosphate-cyclohydrolase I (GTP-CH)] in primary human monocytes and the cell line THP-1.	Iron	13-17	interferon gamma	Homo sapiens	28-44
12885946-1	2003	To elucidate iron-regulated interferon-gamma (IFN-gamma) effector functions, we investigated three IFN-gamma-inducible genes [intercellular adhesion molecule-1 (ICAM-1), human leukocyte antigen (HLA)-DR, guanosine 5"-triphosphate-cyclohydrolase I (GTP-CH)] in primary human monocytes and the cell line THP-1.	Iron	13-17	interferon gamma	Homo sapiens	46-55
12885946-1	2003	To elucidate iron-regulated interferon-gamma (IFN-gamma) effector functions, we investigated three IFN-gamma-inducible genes [intercellular adhesion molecule-1 (ICAM-1), human leukocyte antigen (HLA)-DR, guanosine 5"-triphosphate-cyclohydrolase I (GTP-CH)] in primary human monocytes and the cell line THP-1.	Iron	13-17	interferon gamma	Homo sapiens	99-108
12885946-5	2003	IFN-gamma-inducible mRNA expression of ICAM-1, HLA-DR, and GTP-CH was reduced by iron and increased by DFO by a transcriptional mechanism.	Iron	81-85	interferon gamma	Homo sapiens	0-9
12900941-5	2003	Exposure to iron particles at a concentration of 90 microg/m(3) resulted in a significant decrease in total antioxidant power along with a significant induction in ferritin expression, GST activity, and IL-1beta levels in lungs compared with lungs of the FA control or of animals exposed to iron particles at 57 microg/m(3).	Iron	12-16	interleukin 1 beta	Rattus norvegicus	203-211
14513972-4	2003	Liver cell cultures treated with EPA/DHA revealed that the synergistic effect could be related to an EPA/DHA dependent regulation of mRNA for proteins important for transport (transferrin) and storage (ferritin) of iron in the salmon.	Iron	215-219	serotransferrin-1	Salmo salar	176-187
12885946-7	2003	Thus, iron perturbations regulate IFN-gamma effector pathways by transcriptional and post-transcriptional mechanisms, indicating that iron rather interferes with IFN-gamma signal-transduction processes.	Iron	134-138	interferon gamma	Homo sapiens	34-43
12885946-7	2003	Thus, iron perturbations regulate IFN-gamma effector pathways by transcriptional and post-transcriptional mechanisms, indicating that iron rather interferes with IFN-gamma signal-transduction processes.	Iron	134-138	interferon gamma	Homo sapiens	162-171
12846752-0	2003	Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin.	Iron	10-14	erythropoietin	Homo sapiens	101-115
14598909-6	2003	The Fe-deficient diet also induced an immediate fall in plasma Fe concentration, transferrin saturation, and apparent Fe absorption, while the concentrations of liver cytochrome c increased as Fe deficiency developed.	Iron	4-6	transferrin	Rattus norvegicus	81-92
14598909-7	2003	Decreases in liver and spleen Fe levels, as well as the activities of blood and bone marrow aminolevulinic acid dehydratase (ALA-D, EC 4.2.1.24) were observed 3, 7, and 14 d after feeding the Fe-deficient diet, and thereafter they were increased.	Iron	192-194	aminolevulinate dehydratase	Rattus norvegicus	92-123
14598909-7	2003	Decreases in liver and spleen Fe levels, as well as the activities of blood and bone marrow aminolevulinic acid dehydratase (ALA-D, EC 4.2.1.24) were observed 3, 7, and 14 d after feeding the Fe-deficient diet, and thereafter they were increased.	Iron	192-194	aminolevulinate dehydratase	Rattus norvegicus	125-130
12868065-8	2003	This latter finding indicates that fibrillar human Abeta is able to reduce iron-induced neurotoxicity in vivo and raises the interesting possibility that senile plaques in AD may represent a neuroprotective response to the presence of elevated metal ions.	Iron	75-79	amyloid beta precursor protein	Homo sapiens	51-56
12846752-9	2003	CONCLUSION: Iron supplementation in ESRD patients down-regulates proinflammatory immune effector pathways and stimulates the expression of the anti-inflammatory cytokine IL-4.	Iron	12-16	interleukin 4	Homo sapiens	170-174
12846772-2	2003	During long-term treatment with human recombinant erythropoietin (rhEPO), the majority of end-stage renal disease (ESRD) patients will not respond adequately to rhEPO unless substituted with intravenous iron.	Iron	203-207	erythropoietin	Homo sapiens	50-64
12846752-5	2003	RESULTS: Tumor necrosis factor-alpha (TNF-alpha) levels were increased in ESRD patients at study entry and then decreased significantly over time in subjects receiving additional iron, while they increased with rhEPO alone.	Iron	179-183	tumor necrosis factor	Homo sapiens	9-36
12846752-5	2003	RESULTS: Tumor necrosis factor-alpha (TNF-alpha) levels were increased in ESRD patients at study entry and then decreased significantly over time in subjects receiving additional iron, while they increased with rhEPO alone.	Iron	179-183	tumor necrosis factor	Homo sapiens	38-47
12846752-7	2003	A significant negative correlation between iron availability, as determined by transferrin saturation, and TNF-alpha levels (P = 0.008) and a positive one between transferring saturation and IL-4 (P = 0.02) pointed to the potential role of iron to induce immunologic changes.	Iron	43-47	transferrin	Homo sapiens	79-90
12846752-7	2003	A significant negative correlation between iron availability, as determined by transferrin saturation, and TNF-alpha levels (P = 0.008) and a positive one between transferring saturation and IL-4 (P = 0.02) pointed to the potential role of iron to induce immunologic changes.	Iron	43-47	tumor necrosis factor	Homo sapiens	107-116
12888304-1	2003	The regimen outlined in this brief paper focuses on therapeutically utilizing iron and iron compounds in transferrin receptor-rich tumor cells in ways that inhibit and lyse same.	Iron	78-82	transferrin	Homo sapiens	105-116
12888304-1	2003	The regimen outlined in this brief paper focuses on therapeutically utilizing iron and iron compounds in transferrin receptor-rich tumor cells in ways that inhibit and lyse same.	Iron	87-91	transferrin	Homo sapiens	105-116
12895270-7	2003	Iron overload may be responsible for insulin resistance, or vice versa.	Iron	0-4	insulin	Homo sapiens	37-44
12846752-8	2003	Interestingly, iron therapy resulted in a slight decrease in the amounts of endogenous peroxides, which may be referred to reduced TNF-alpha concentrations since peroxide concentrations were positively correlated to TNF-alpha levels (P = 0.046) and negatively to transferrin saturation (P = 0.02).	Iron	15-19	tumor necrosis factor	Homo sapiens	131-140
12846752-8	2003	Interestingly, iron therapy resulted in a slight decrease in the amounts of endogenous peroxides, which may be referred to reduced TNF-alpha concentrations since peroxide concentrations were positively correlated to TNF-alpha levels (P = 0.046) and negatively to transferrin saturation (P = 0.02).	Iron	15-19	tumor necrosis factor	Homo sapiens	216-225
12846752-8	2003	Interestingly, iron therapy resulted in a slight decrease in the amounts of endogenous peroxides, which may be referred to reduced TNF-alpha concentrations since peroxide concentrations were positively correlated to TNF-alpha levels (P = 0.046) and negatively to transferrin saturation (P = 0.02).	Iron	15-19	transferrin	Homo sapiens	263-274
12918124-1	2003	AIM: Heme oxygenase (HO)-1 catalyzes the conversion of heme to biliverdin, iron and carbon monoxide.	Iron	75-79	heme oxygenase 1	Mus musculus	5-26
12926842-6	2003	In the SJL model of EAE, extravasated blood is present in the CNS, and iron released by HO-1 from this heme source may not be adequately sequestered by ferritin, allowing for iron-mediated tissue damage.	Iron	71-75	heme oxygenase 1	Mus musculus	88-92
14580149-6	2003	Desferrioxamine, an iron chelator that mimics hypoxia in vitro, also inhibited the fractalkine production induced by IFN-gamma.	Iron	20-24	C-X3-C motif chemokine ligand 1	Homo sapiens	83-94
14580149-6	2003	Desferrioxamine, an iron chelator that mimics hypoxia in vitro, also inhibited the fractalkine production induced by IFN-gamma.	Iron	20-24	interferon gamma	Homo sapiens	117-126
12940442-3	2003	The cytokine TNF-alpha is implicated in the regulation of iron metabolism at different levels.	Iron	58-62	tumor necrosis factor	Homo sapiens	13-22
12851122-7	2003	For example, transferrin receptor, a gene known to control cellular iron uptake, was downregulated in the cells treated with the iron-containing PA coal in order to protect cells from iron overload.	Iron	68-72	transferrin	Homo sapiens	13-24
12878045-9	2003	However, the addition of 45 microg/m3 of iron to soot with a combined total mass concentration of 250 microg/m3 demonstrated significant pulmonary ferritin induction, oxidative stress, elevation of IL-1beta, and cytochrome P450s, as well as activation of NFkappaB.	Iron	41-45	interleukin 1 beta	Rattus norvegicus	198-206
12730244-1	2003	Grx5 is a yeast mitochondrial protein involved in iron-sulfur biogenesis that belongs to a recently described family of monothiolic glutaredoxin-like proteins.	Iron	50-54	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	0-4
12756250-0	2003	Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements.	Iron	24-28	Aft2p	Saccharomyces cerevisiae S288C	10-15
12851122-7	2003	For example, transferrin receptor, a gene known to control cellular iron uptake, was downregulated in the cells treated with the iron-containing PA coal in order to protect cells from iron overload.	Iron	129-133	transferrin	Homo sapiens	13-24
12851122-7	2003	For example, transferrin receptor, a gene known to control cellular iron uptake, was downregulated in the cells treated with the iron-containing PA coal in order to protect cells from iron overload.	Iron	129-133	transferrin	Homo sapiens	13-24
12827660-0	2003	Developing human erythroid cells grown in transferrin-free medium utilize iron originating from extracellular ferritin.	Iron	74-78	transferrin	Homo sapiens	42-53
12709425-5	2003	We isolated Lenramp1 and Lenramp3 from tomato and demonstrate that these genes encode functional NRAMP metal transporters in yeast, where they were iron-regulated and localized mainly to intracellular vesicles.	Iron	148-152	root-specific metal transporter	Solanum lycopersicum	12-20
12709425-7	2003	Lenramp1 and Leirt1, but not Lenramp3 and Leirt2, were down-regulated in the roots of fer mutant plants deficient in a bHLH gene regulating iron uptake.	Iron	140-144	root-specific metal transporter	Solanum lycopersicum	0-8
12709425-11	2003	Based on our results, we suggest a novel function for NRAMP1 in mobilizing iron in the vascular parenchyma upon iron deficiency in plants.	Iron	75-79	root-specific metal transporter	Solanum lycopersicum	54-60
12637325-4	2003	Regulation of hepcidin mRNA expression in response to transferrin-bound iron, non-transferrin-bound iron, and deferoxamine was analyzed in HepG2 cells.	Iron	72-76	transferrin	Homo sapiens	54-65
12830468-1	2003	BACKGROUND: Ascorbic acid supplementation has been recommended to circumvent resistance to erythropoietin, which sometimes occurs in iron-overloaded uremic patients.	Iron	133-137	erythropoietin	Homo sapiens	91-105
12788784-2	2003	An important role for iron in the embryonic kidney was first identified by Ekblom, who studied transferrin (Landschulz W and Ekblom P. J Biol Chem 260: 15580-15584, 1985; Landschulz W, Thesleff I, and Ekblom P. J Cell Biol 98: 596-601, 1984; Thesleff I, Partanen AM, Landschulz W, Trowbridge IS, and Ekblom P. Differentiation 30: 152- 158, 1985).	Iron	22-26	transferrin	Homo sapiens	95-106
12941522-0	2003	Over-expression of wild-type and mutant HFE in a human melanocytic cell line reveals an intracellular bridge between MHC class I pathway and transferrin iron uptake.	Iron	153-157	transferrin	Homo sapiens	141-152
12821113-4	2003	Iron (HIF-1 inhibitor) inhibited increase of HIF-1alpha and NF-kappaB protein levels.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	6-11
12821113-4	2003	Iron (HIF-1 inhibitor) inhibited increase of HIF-1alpha and NF-kappaB protein levels.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
12637325-10	2003	Although the causality is not yet clear, this interaction might result from a down-regulation of hepcidin expression in response to significant levels of non-transferrin-bound iron.	Iron	176-180	transferrin	Homo sapiens	158-169
14569286-5	2003	ETA production was enhanced but still iron regulated in the PAO1 strain PAO1-XR that carries two copies of ptxR on its chromosome.	Iron	38-42	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	107-111
12914908-5	2003	The formal potential of Cat Fe(III)/Fe(II) couples in PAM films had a linear relationship with pH between pH 4.0 and 9.0 with a slope of -56 mV pH(-1), suggesting that one proton is coupled with single-electron transfer for each heme group of catalase in the electrode reaction.	Iron	28-30	catalase	Homo sapiens	24-27
12914908-5	2003	The formal potential of Cat Fe(III)/Fe(II) couples in PAM films had a linear relationship with pH between pH 4.0 and 9.0 with a slope of -56 mV pH(-1), suggesting that one proton is coupled with single-electron transfer for each heme group of catalase in the electrode reaction.	Iron	28-30	catalase	Homo sapiens	243-251
14569286-7	2003	In contrast to PAO1-XR, ETA activity produced by PA103-2R, a PA103 strain carrying two copies of ptxR, is enhanced tenfold and partially deregulated in the presence of iron.	Iron	168-172	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	97-101
17003017-11	2003	Hence, the relative iron "overload" in offspring of type 2 diabetics is present along with insulin resistance and might worsen the hepatic insulin insensitivity already present in these patients.	Iron	20-24	insulin	Homo sapiens	91-98
17003017-11	2003	Hence, the relative iron "overload" in offspring of type 2 diabetics is present along with insulin resistance and might worsen the hepatic insulin insensitivity already present in these patients.	Iron	20-24	insulin	Homo sapiens	139-146
12884407-7	2003	The results suggest that Mn-exposed workers have higher intracellular iron concentration in the erythrocyte precursors than the controls, resulting in a down-regulation of transferrin receptors on the surface of these cells.	Iron	70-74	transferrin	Homo sapiens	172-183
14696757-1	2003	BACKGROUND: An inverse correlation between Kt/V and epoetin requirement has recently been demonstrated in stable hemodialysis (HD) patients with adequate iron stores, dialyzed with cellulosic membranes.	Iron	154-158	erythropoietin	Homo sapiens	52-59
12851791-4	2003	We propose a comparative study of the X-ray absorption spectra at the K-edge of iron, copper, zinc and nickel in serotransferrin and ovotransferrin.	Iron	80-84	transferrin	Homo sapiens	113-128
12833069-1	2003	Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.	Iron	89-93	transferrin	Homo sapiens	15-26
14509218-16	2003	Accordingly, if long-acting EPO is available for non-dialysis CRF patients, the CHr value is likely to be indicative of the need for iron supplementation.	Iron	133-137	erythropoietin	Homo sapiens	28-31
12915222-4	2003	Following eight weeks of iron supplementation, the mean serum ferritin, iron, and transferrin saturation significantly increased and the total iron binding capacity significantly decreased in the iron deficient group.	Iron	25-29	transferrin	Homo sapiens	82-93
14587253-11	2003	Specific proteins that are cytotoxic are transferrin/iron, low-density lipoprotein, and complement components, all of which appear in urine in proteinuric states.	Iron	53-57	transferrin	Homo sapiens	41-52
12795604-2	2003	Structurally, the transferrin molecule is folded into two globular lobes, representing its N-terminal and C-terminal halves, with each lobe possessing a high-affinity iron binding site, in a cleft between two domains.	Iron	167-171	transferrin	Homo sapiens	18-29
12879735-2	2003	Moreover, lack of available iron is the most common reason for unresponsiveness to epoetin in patients on chronic dialysis.	Iron	28-32	erythropoietin	Homo sapiens	83-90
12787877-1	2003	It is widely assumed that standard parenteral iron preparations are degraded in the reticuloendothelial cells and that the iron is subsequently incorporated into transferrin.	Iron	123-127	transferrin	Homo sapiens	162-173
12646040-1	2003	Divalent-metal transporter 1 (DMT1) is involved in the intestinal iron absorption and in iron transport in the transferrin cycle.	Iron	89-93	transferrin	Homo sapiens	111-122
12787877-4	2003	By using the human hepatoma cell line HepG2 we showed that the parenteral iron preparations ferric saccharate and ferric gluconate donated iron to the cells as efficiently as low molecular weight iron and stimulated non-transferrin bound iron uptake.	Iron	74-78	transferrin	Homo sapiens	220-231
12787877-10	2003	Further the increase in the expression of the transporter DMT-1 in HepG2 cells after iron treatment is in contrast to the regulation in the duodenum and may be involved in the upregulated uptake of potentially toxic non-transferrin bound iron from the circulation to store it in the non-toxic form of ferritin.	Iron	85-89	transferrin	Homo sapiens	220-231
12787877-10	2003	Further the increase in the expression of the transporter DMT-1 in HepG2 cells after iron treatment is in contrast to the regulation in the duodenum and may be involved in the upregulated uptake of potentially toxic non-transferrin bound iron from the circulation to store it in the non-toxic form of ferritin.	Iron	238-242	transferrin	Homo sapiens	220-231
12957295-13	2003	Mitochondrial membrane potential and ATP levels were decreased, and damage to the mitochondria played a critical role in the CYP2E1-plus-iron-dependent toxicity.	Iron	137-141	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	125-131
12957294-8	2003	Moreover, the iron treatment increased TNF-alpha release and TNF-alpha promoter activity in a NF-kappaB-dependent manner.	Iron	14-18	tumor necrosis factor	Rattus norvegicus	39-48
12957294-8	2003	Moreover, the iron treatment increased TNF-alpha release and TNF-alpha promoter activity in a NF-kappaB-dependent manner.	Iron	14-18	tumor necrosis factor	Rattus norvegicus	61-70
12957294-9	2003	Ferrous iron also transiently decreased cytoplasmic I-kappa B-alpha (IkappaB-alpha), with concomitant increases in nuclear p65 protein and DNA binding of p65/p50.	Iron	0-12	synaptotagmin 1	Rattus norvegicus	123-126
12957294-9	2003	Ferrous iron also transiently decreased cytoplasmic I-kappa B-alpha (IkappaB-alpha), with concomitant increases in nuclear p65 protein and DNA binding of p65/p50.	Iron	0-12	synaptotagmin 1	Rattus norvegicus	154-157
12957295-4	2003	The ability of iron to modulate the biochemical and toxicologic actions of cytochrome P450 2E1 (CYP2E1) has been evaluated by using isolated microsomes and intact liver cells.	Iron	15-19	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	75-94
12856975-0	2003	Transferrin receptor in children and its correlation with iron status and types of milk consumption.	Iron	58-62	transferrin	Homo sapiens	0-11
12957295-14	2003	These results support the suggestion that low concentrations of iron and polyunsaturated fatty acids can act as priming or sensitizing factors for CYP2E1-induced injury in HepG2 cells and hepatocytes.	Iron	64-68	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	147-153
12957295-4	2003	The ability of iron to modulate the biochemical and toxicologic actions of cytochrome P450 2E1 (CYP2E1) has been evaluated by using isolated microsomes and intact liver cells.	Iron	15-19	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102
12957295-7	2003	Reactive oxygen production, lipid peroxidation, and interaction with iron chelates have been shown to be enhanced with microsomes isolated from ethanol-treated rats with elevated levels of CYP2E1.	Iron	69-73	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	189-195
12957299-2	2003	Results of clinical and epidemiologic studies demonstrate a strong association between iron excess (even at mild levels) and the development of cancer at any site, but they do not indicate whether this reflects a causal link or an indirect association through other factors (i.e., aging, alcohol consumption, and insulin resistance).	Iron	87-91	insulin	Homo sapiens	313-320
12957295-9	2003	Thus, in the presence of iron complexes, microsomes enriched in CYP2E1 are especially reactive in generation of reactive oxygen species.	Iron	25-29	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	64-70
12957295-10	2003	To assess the toxicologic significance of this iron-CYP2E1 interaction, iron (ferric-nitrilotriacetate) was added to HepG2 cells, which were engineered to express the human CYP2E1.	Iron	47-51	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	173-179
12807743-0	2003	Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation.	Iron	7-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	98-101
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	202-204	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-147
12734107-2	2003	DMT1, also known as Nramp2 and DCT1, is the transporter responsible for intestinal iron uptake.	Iron	83-87	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Gallus gallus	20-26
12572687-9	2003	However, increased levels of LMW iron were obtained at higher transferrin (Tf) saturation (1.64-2.54 microM range at 80% Tf saturation, 2.77-3.15 microM range at 100% Tf saturation and 3.09-3.39 microM range at 120% Tf saturation).	Iron	33-37	transferrin	Homo sapiens	62-73
12807743-0	2003	Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation.	Iron	7-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	102-106
12807743-0	2003	Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation.	Iron	7-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	107-111
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	94-96	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-62
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	94-96	cyclin dependent kinase inhibitor 1A	Homo sapiens	63-67
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	94-96	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-72
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	94-96	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-147
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	94-96	cyclin dependent kinase inhibitor 1A	Homo sapiens	148-152
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	94-96	cyclin dependent kinase inhibitor 1A	Homo sapiens	153-157
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	202-204	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-62
12807743-14	2003	Significantly, the effect of chelation on reducing nuclear p21(CIP1/WAF1) was reversed by the Fe donor ferric ammonium citrate, indicating that p21(CIP1/WAF1) translation was dependent on intracellular Fe levels.	Iron	202-204	cyclin dependent kinase inhibitor 1A	Homo sapiens	63-67
12806616-8	2003	In multivariate logistic regression analyses, elevated ALT level was associated positively with increasing deciles of transferrin saturation (odds ratio [OR] per decile, 1.10; 95% confidence interval [CI], 1.03-1.18) and iron concentration (OR, 1.13; 95% CI, 1.06-1.21).	Iron	221-225	transferrin	Homo sapiens	118-129
12757983-8	2003	Furthermore, the group in the upper quartile for insulin resistance showed higher hemoglobin concentrations and WBC counts than the lower quartile, independent of smoking status and serum iron concentrations.	Iron	188-192	insulin	Homo sapiens	49-56
12757853-3	2003	Rats, preloaded with iron, had evidence of both iron deposition and strong iNOS induction in liver Kupffer cells upon injection of LPS; phagocytic cells in the spleen and lung had similar findings.	Iron	21-25	nitric oxide synthase 2	Rattus norvegicus	75-79
12757853-5	2003	Western blot analysis showed that iron preloading significantly enhanced LPS-induced iNOS induction in the liver, but not in the spleen or lung.	Iron	34-38	nitric oxide synthase 2	Rattus norvegicus	85-89
12757853-6	2003	LPS-induced plasma levels of IL-6, IL-1beta, and TNF-alpha were also significantly higher in iron-preloaded rats as shown by ELISA, but IFN-gamma levels were unchanged.	Iron	93-97	interleukin 6	Rattus norvegicus	29-33
12757853-6	2003	LPS-induced plasma levels of IL-6, IL-1beta, and TNF-alpha were also significantly higher in iron-preloaded rats as shown by ELISA, but IFN-gamma levels were unchanged.	Iron	93-97	interleukin 1 beta	Rattus norvegicus	35-43
12757853-6	2003	LPS-induced plasma levels of IL-6, IL-1beta, and TNF-alpha were also significantly higher in iron-preloaded rats as shown by ELISA, but IFN-gamma levels were unchanged.	Iron	93-97	tumor necrosis factor	Rattus norvegicus	49-58
12757853-7	2003	We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS-induced NO production in vivo, iNOS induction in the liver, and release of IL-6, IL-1beta, and TNF-alpha.	Iron	27-31	nitric oxide synthase 2	Rattus norvegicus	112-116
12757853-7	2003	We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS-induced NO production in vivo, iNOS induction in the liver, and release of IL-6, IL-1beta, and TNF-alpha.	Iron	27-31	interleukin 6	Rattus norvegicus	156-160
12757853-7	2003	We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS-induced NO production in vivo, iNOS induction in the liver, and release of IL-6, IL-1beta, and TNF-alpha.	Iron	27-31	interleukin 1 beta	Rattus norvegicus	162-170
12757853-7	2003	We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS-induced NO production in vivo, iNOS induction in the liver, and release of IL-6, IL-1beta, and TNF-alpha.	Iron	27-31	tumor necrosis factor	Rattus norvegicus	176-185
12829269-6	2003	For pathogens, host-iron complexes (transferrin, lactoferrin, haem, haemoglobin) are directly used as iron sources.	Iron	20-24	transferrin	Homo sapiens	36-47
12829269-6	2003	For pathogens, host-iron complexes (transferrin, lactoferrin, haem, haemoglobin) are directly used as iron sources.	Iron	102-106	transferrin	Homo sapiens	36-47
12774019-5	2003	HepG2 cells over-expressing CYP2E1 (E47 cells) were treated with arachidonic acid (AA) plus iron, agents important in development of alcoholic liver injury and which are toxic to E47 cells by a mechanism dependent on CYP2E1, oxidative stress, and lipid peroxidation.	Iron	92-96	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	28-34
12781465-1	2003	Mass spectrometry, proteomics, and protein chemistry methods are used to characterize the cleavage products of 79 kDa transferrin proteins induced by iron-catalyzed oxidation, including a novel C-terminal polypeptide released upon disulfide reduction.	Iron	150-154	transferrin	Homo sapiens	118-129
12801838-0	2003	Erythroid bone marrow activity and red cell hemoglobinization in iron sufficient beta-thalassemia heterozygotes as reflected by soluble transferrin receptor and reticulocyte hemoglobin in content.	Iron	65-69	transferrin	Homo sapiens	136-147
18494894-9	2003	Some bacterial species could additionally utilize iron bound to the iron carrier protein transferrin present in eccrine sweat.	Iron	50-54	transferrin	Homo sapiens	89-100
18494894-9	2003	Some bacterial species could additionally utilize iron bound to the iron carrier protein transferrin present in eccrine sweat.	Iron	68-72	transferrin	Homo sapiens	89-100
18494894-10	2003	This was minimized by the use of an agent, butylated hydroxytoluene (BHT), capable of liberating iron from transferrin via reduction of transferrin-bound ferric ions, allowing subsequent sequestration of Fe(II).	Iron	97-101	transferrin	Homo sapiens	107-118
18494894-10	2003	This was minimized by the use of an agent, butylated hydroxytoluene (BHT), capable of liberating iron from transferrin via reduction of transferrin-bound ferric ions, allowing subsequent sequestration of Fe(II).	Iron	97-101	transferrin	Homo sapiens	136-147
18494894-19	2003	The combination of an efficient iron chelator with an agent capable of liberating iron from transferrin offers significant benefits in terms of bacterial growth inhibition on the skin and provides a new route to axillary deodorancy.	Iron	32-36	transferrin	Homo sapiens	92-103
18494894-19	2003	The combination of an efficient iron chelator with an agent capable of liberating iron from transferrin offers significant benefits in terms of bacterial growth inhibition on the skin and provides a new route to axillary deodorancy.	Iron	82-86	transferrin	Homo sapiens	92-103
19379368-3	2003	Recently, however, the trend to administer maintenance iron with resultant high serum ferritin and high transferrin saturation has led to an increase in reports of iron overload.	Iron	55-59	transferrin	Homo sapiens	104-115
19379368-3	2003	Recently, however, the trend to administer maintenance iron with resultant high serum ferritin and high transferrin saturation has led to an increase in reports of iron overload.	Iron	164-168	transferrin	Homo sapiens	104-115
12781465-7	2003	Iron-catalyzed cleavage induces fragments originating from both the N- and C-terminus of transferrin.	Iron	0-4	transferrin	Homo sapiens	89-100
12749025-0	2003	Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.	Iron	146-150	glucagon	Homo sapiens	0-23
12626517-1	2003	Human heme oxygenase-1 (hHO-1) catalyzes the NADPH-cytochrome P450 reductase-dependent oxidation of heme to biliverdin, CO, and free iron.	Iron	133-137	cytochrome p450 oxidoreductase	Homo sapiens	45-76
27319257-1	2003	The RCN is to continue lobbying this month for a "cast iron guarantee" that nurses will sit on the executive boards of NHS foundation trusts.	Iron	55-59	reticulocalbin 1	Homo sapiens	4-7
12798850-4	2003	EPO therapy is efficient, in moderate anaemic patients, to reduce allogeneic transfusion when iron supplementation is associated.	Iron	94-98	erythropoietin	Homo sapiens	0-3
12881862-0	2003	[Modulation of iron on the vasodilating effect of interleukin-2 in the isolated aortic ring].	Iron	15-19	interleukin 2	Homo sapiens	50-63
12881862-1	2003	OBJECTIVE: To explore the effect and mechanism of iron on the vasodilating effect of interleukin-2 (IL-2) in the isolated aortic ring.	Iron	50-54	interleukin 2	Homo sapiens	85-98
12881862-1	2003	OBJECTIVE: To explore the effect and mechanism of iron on the vasodilating effect of interleukin-2 (IL-2) in the isolated aortic ring.	Iron	50-54	interleukin 2	Homo sapiens	100-104
12646553-3	2003	Here we demonstrate that cytochrome c is nitrosylated on its heme iron during apoptosis.	Iron	66-70	cytochrome c, somatic	Homo sapiens	25-37
12646553-9	2003	We conclude that nitrosylation of the heme iron of cytochrome c may be a novel mechanism of apoptosis regulation.	Iron	43-47	cytochrome c, somatic	Homo sapiens	51-63
12726917-4	2003	We hypothesized that an amine derivative of alpha-lipoamide (LM), 5-[1,2] dithiolan-3-yl-pentanoic acid (2-dimethylamino-ethyl)-amide (alpha-lipoic acid-plus [LAP]; pKa = 8.0), would concentrate via proton trapping within lysosomes, and that the vicinal thiols of the reduced form of this agent would interact with intralysosomal iron, preventing oxidant-mediated cell damage.	Iron	330-334	acid phosphatase, prostate	Mus musculus	135-157
12522003-4	2003	Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition.	Iron	140-144	interferon gamma	Homo sapiens	33-49
12522003-4	2003	Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition.	Iron	140-144	interferon gamma	Homo sapiens	51-60
12522003-4	2003	Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition.	Iron	242-246	interferon gamma	Homo sapiens	33-49
12522003-4	2003	Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition.	Iron	242-246	interferon gamma	Homo sapiens	51-60
12522003-5	2003	IFN-gamma and LPS dose-dependently increased the cellular expression of divalent metal transporter-1, a transmembrane transporter of ferrous iron, and stimulated the uptake of nontransferrin bound iron (NTBI) into cells.	Iron	141-145	interferon gamma	Homo sapiens	0-9
12522003-5	2003	IFN-gamma and LPS dose-dependently increased the cellular expression of divalent metal transporter-1, a transmembrane transporter of ferrous iron, and stimulated the uptake of nontransferrin bound iron (NTBI) into cells.	Iron	197-201	interferon gamma	Homo sapiens	0-9
12522003-6	2003	At the same time, IFN-gamma and LPS down-regulated the expression of ferroportin mRNA, a putative iron exporter, and decreased iron release from monocytes.	Iron	98-102	interferon gamma	Homo sapiens	18-27
12522003-6	2003	At the same time, IFN-gamma and LPS down-regulated the expression of ferroportin mRNA, a putative iron exporter, and decreased iron release from monocytes.	Iron	127-131	interferon gamma	Homo sapiens	18-27
12739968-1	2003	A key issue regarding the speciation of Al(3+) in serum is how well the ligands citric acid and phosphate can compete with the iron transport protein serum transferrin for the aluminum.	Iron	127-131	transferrin	Homo sapiens	156-167
12731884-1	2003	Human serum transferrin (hTF) is an iron transport protein, comprising two lobes (N and C), each containing a single metal-binding center.	Iron	36-40	transferrin	Homo sapiens	12-23
12793906-2	2003	Several studies indicate that a reduction step of ferric iron to ferrous is necessary, both in the case of transferrin-mediated and transferrin-independent iron uptake.	Iron	57-61	transferrin	Homo sapiens	107-118
12793906-2	2003	Several studies indicate that a reduction step of ferric iron to ferrous is necessary, both in the case of transferrin-mediated and transferrin-independent iron uptake.	Iron	57-61	transferrin	Homo sapiens	132-143
12793906-7	2003	The uptake of transferrin-bound iron was investigated by using 55Fe-loaded transferrin, as well as by monitoring fluorimetrically the intracellular iron levels in calcein-preloaded cells.	Iron	32-36	transferrin	Homo sapiens	14-25
12793906-7	2003	The uptake of transferrin-bound iron was investigated by using 55Fe-loaded transferrin, as well as by monitoring fluorimetrically the intracellular iron levels in calcein-preloaded cells.	Iron	32-36	transferrin	Homo sapiens	75-86
12793906-7	2003	The uptake of transferrin-bound iron was investigated by using 55Fe-loaded transferrin, as well as by monitoring fluorimetrically the intracellular iron levels in calcein-preloaded cells.	Iron	148-152	transferrin	Homo sapiens	14-25
12793906-8	2003	Transferrin-independent iron uptake was investigated using 55Fe complexed by nitrilotriacetic acid (55Fe-NTA complex).The stimulation of GGT activity, by administration to cells of the substrates glutathione and glycyl-glycine, was generally reflected in a facilitation of transferrin-bound iron uptake.	Iron	24-28	transferrin	Homo sapiens	0-11
12793906-10	2003	Accordingly, inhibition of GGT activity by means of two independent inhibitors, acivicin and serine/boric acid complex, resulted in a decreased uptake of transferrin-bound iron.	Iron	172-176	transferrin	Homo sapiens	154-165
12793906-0	2003	Possible role of membrane gamma-glutamyltransferase activity in the facilitation of transferrin-dependent and -independent iron uptake by cancer cells.	Iron	123-127	transferrin	Homo sapiens	84-95
12740813-9	2003	Finally, Fe(II/III) gives a much lower reorganisation energy than Co(II/III); this is owing to the occupied d(z2) orbital in Co(II).	Iron	9-11	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	15-18
12740813-9	2003	Finally, Fe(II/III) gives a much lower reorganisation energy than Co(II/III); this is owing to the occupied d(z2) orbital in Co(II).	Iron	9-11	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	72-75
12740813-9	2003	Finally, Fe(II/III) gives a much lower reorganisation energy than Co(II/III); this is owing to the occupied d(z2) orbital in Co(II).	Iron	9-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
12628824-1	2003	Transparent protein film of iron-free cytochrome c (<protein-id="54205">Cyt.	Iron	28-32	cytochrome c, somatic	Homo sapiens	38-50
12718557-5	2003	On the basis of the nu(Fe-CO) and nu(C-O) values in the resonance Raman and infrared spectra of the ferrous-CO complexes of Cgb and its mutants, it was found that CO binds to the ferrous iron after the His81 imidazole is dissociated, and three conformers are present in the resultant CO coordination structure.	Iron	187-191	cytoglobin	Homo sapiens	124-127
12707050-10	2003	This suggests that transferrin may be an important factor in the activation of hepatic stellate cells in conditions of iron overload.	Iron	119-123	transferrin	Rattus norvegicus	19-30
12737947-4	2003	We propose that the liver plays a central role in the maintenance of iron homeostasis by regulating the expression of hepcidin in response to changes in the ratio of diferric transferrin in the circulation to the level of transferrin receptor 1.	Iron	69-73	transferrin	Homo sapiens	175-186
12737947-4	2003	We propose that the liver plays a central role in the maintenance of iron homeostasis by regulating the expression of hepcidin in response to changes in the ratio of diferric transferrin in the circulation to the level of transferrin receptor 1.	Iron	69-73	transferrin	Homo sapiens	222-233
12738232-0	2003	Differential accumulation of non-transferrin-bound iron by cardiac myocytes and fibroblasts.	Iron	51-55	transferrin	Rattus norvegicus	33-44
12704209-3	2003	HFE is expressed in small intestinal crypt cells where transferrin-iron entry may determine subsequent iron absorption by mature enterocytes, but the physiological function of TfR2 is unknown.	Iron	67-71	transferrin	Homo sapiens	55-66
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	148-152	transferrin	Homo sapiens	163-174
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	305-309	transferrin	Homo sapiens	163-174
12700102-0	2003	Transferrin-iron uptake by Gram-negative bacteria.	Iron	12-16	transferrin	Homo sapiens	0-11
12700102-1	2003	Members of the families Neisseriaceae, Pasteurellaceae and Moraxellaceae are capable of transferrin-iron acquisition in the absence of siderophore production.	Iron	100-104	transferrin	Homo sapiens	88-99
12700102-3	2003	Both proteins are surface exposed, iron-regulated and capable of binding transferrin.	Iron	35-39	transferrin	Homo sapiens	73-84
12700102-8	2003	However, unlike the other TonB-dependent receptors where vitamins or ferric-siderophores are wholly internalized, the bacterial transferrin receptor must remove iron from transferrin at the cell surface.	Iron	161-165	transferrin	Homo sapiens	128-139
12700102-8	2003	However, unlike the other TonB-dependent receptors where vitamins or ferric-siderophores are wholly internalized, the bacterial transferrin receptor must remove iron from transferrin at the cell surface.	Iron	161-165	transferrin	Homo sapiens	171-182
12700102-9	2003	This review focuses on the structure-function relationships in the transferrin-binding proteins, their sequence and antigenic diversity, and the mechanisms by which they accomplish transferrin-iron uptake.	Iron	193-197	transferrin	Homo sapiens	67-78
12700102-9	2003	This review focuses on the structure-function relationships in the transferrin-binding proteins, their sequence and antigenic diversity, and the mechanisms by which they accomplish transferrin-iron uptake.	Iron	193-197	transferrin	Homo sapiens	181-192
12713595-0	2003	Iron chelators inhibit VCAM-1 expression in human dermal microvascular endothelial cells.	Iron	0-4	vascular cell adhesion molecule 1	Homo sapiens	23-29
12713595-2	2003	To investigate the role of iron in TNF alpha-induced VCAM-1 gene expression, human dermal microvascular endothelial cells (HDMEC) were stimulated with TNF alpha in the presence of iron chelators and examined for expression of VCAM-1.	Iron	27-31	tumor necrosis factor	Homo sapiens	35-44
12713595-3	2003	The iron chelators dipyridyl (DP) and desferoxamine (DFO) inhibited VCAM-1 protein and mRNA induction in a concentration- and time-dependent manner.	Iron	4-8	vascular cell adhesion molecule 1	Homo sapiens	68-74
12713595-4	2003	The induction of VCAM-1 was not inhibited by nonmetal binding reactive oxygen species (ROS) scavengers, implying a direct effect of iron in the expression of these adhesion molecules.	Iron	132-136	vascular cell adhesion molecule 1	Homo sapiens	17-23
12713595-5	2003	The effect of iron was mediated at the level of gene transcription since pretreatment with DP abrogated the TNF alpha-mediated up-regulation of VCAM-1 heterogeneous nuclear RNA.	Iron	14-18	tumor necrosis factor	Homo sapiens	108-117
12713595-5	2003	The effect of iron was mediated at the level of gene transcription since pretreatment with DP abrogated the TNF alpha-mediated up-regulation of VCAM-1 heterogeneous nuclear RNA.	Iron	14-18	vascular cell adhesion molecule 1	Homo sapiens	144-150
12713595-10	2003	These data suggest that iron plays a critical role in TNF alpha mediated VCAM-1 induction in HDMEC, and the target for iron effects may be IRF-1, NF-kappa B, and potentially chromatin remodeling.	Iron	24-28	tumor necrosis factor	Homo sapiens	54-63
12713595-10	2003	These data suggest that iron plays a critical role in TNF alpha mediated VCAM-1 induction in HDMEC, and the target for iron effects may be IRF-1, NF-kappa B, and potentially chromatin remodeling.	Iron	24-28	vascular cell adhesion molecule 1	Homo sapiens	73-79
12713595-10	2003	These data suggest that iron plays a critical role in TNF alpha mediated VCAM-1 induction in HDMEC, and the target for iron effects may be IRF-1, NF-kappa B, and potentially chromatin remodeling.	Iron	119-123	interferon regulatory factor 1	Homo sapiens	139-144
12713595-10	2003	These data suggest that iron plays a critical role in TNF alpha mediated VCAM-1 induction in HDMEC, and the target for iron effects may be IRF-1, NF-kappa B, and potentially chromatin remodeling.	Iron	119-123	nuclear factor kappa B subunit 1	Homo sapiens	146-156
12730455-6	2003	Recent work established that m-acon expression is translationally regulated by iron in a manner that is strongly correlated with IRP RNA-binding activity.	Iron	79-83	aconitase 2	Homo sapiens	29-35
12730455-8	2003	The changes in m-acon synthesis and abundance in liver during iron deficiency fail to affect TCA-cycle capacity but are associated with a significant upregulation of mitochondrial export of radiolabeled citrate.	Iron	62-66	aconitase 2	Homo sapiens	15-21
12730464-6	2003	For example, transferrin receptor levels increase inversely to maternal Fe levels.	Iron	72-74	transferrin	Homo sapiens	13-24
12716026-3	2003	Treatment with fibroblast growth factor-2, neurotrophin-4, or insulin-like growth factor-1 potentiated neuronal cell death induced by iron-citrate (Fe) or buthionine sulfoximine (BSO), but not ethacrynic acid (EA).	Iron	148-150	fibroblast growth factor 2	Homo sapiens	15-41
12742584-1	2003	We recently reported that Ascaris suum mitochondria express stage-specific isoforms of complex II: the flavoprotein subunit and the small subunit of cytochrome b (CybS) of the larval complex II differ from those of adult enzyme, while two complex IIs share a common iron-sulfur cluster subunit (Ip).	Iron	266-270	CYTB	Ascaris suum	149-161
12704390-10	2003	We found unexpected alterations in the expression of Slc39a1 (mouse ortholog of SLC11A3) and Cybrd1, which encode key iron transport proteins, and Hamp (hepcidin antimicrobial peptide), a hepatic regulator of iron transport.	Iron	118-122	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	80-87
12704390-10	2003	We found unexpected alterations in the expression of Slc39a1 (mouse ortholog of SLC11A3) and Cybrd1, which encode key iron transport proteins, and Hamp (hepcidin antimicrobial peptide), a hepatic regulator of iron transport.	Iron	118-122	cytochrome b reductase 1	Mus musculus	93-99
12704390-11	2003	We propose that inappropriate regulatory cues from the liver underlie greater duodenal iron absorption, possibly involving the ferric reductase Cybrd1.	Iron	87-91	cytochrome b reductase 1	Mus musculus	144-150
12686666-8	2003	RESULTS: HD patients on maintenance iron showed elevated carbonylated fibrinogen compared with healthy subjects.	Iron	36-40	fibrinogen beta chain	Homo sapiens	70-80
12686666-9	2003	During a HD session, carbonyls on fibrinogen further increased when 125 mg iron gluconate was administered, but no changes were detected with 62.5 mg iron gluconate or in the absence of iron.	Iron	75-79	fibrinogen beta chain	Homo sapiens	34-44
12686666-11	2003	CONCLUSIONS: The significant acute increase in carbonylated fibrinogen with 125 mg iron gluconate suggests that this iron dose should be used with caution.	Iron	83-87	fibrinogen beta chain	Homo sapiens	60-70
12686666-12	2003	As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy.	Iron	39-43	fibrinogen beta chain	Homo sapiens	3-13
12686666-12	2003	As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy.	Iron	113-117	fibrinogen beta chain	Homo sapiens	3-13
12686666-12	2003	As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy.	Iron	113-117	fibrinogen beta chain	Homo sapiens	3-13
12716026-3	2003	Treatment with fibroblast growth factor-2, neurotrophin-4, or insulin-like growth factor-1 potentiated neuronal cell death induced by iron-citrate (Fe) or buthionine sulfoximine (BSO), but not ethacrynic acid (EA).	Iron	148-150	neurotrophin 4	Homo sapiens	43-57
12716026-3	2003	Treatment with fibroblast growth factor-2, neurotrophin-4, or insulin-like growth factor-1 potentiated neuronal cell death induced by iron-citrate (Fe) or buthionine sulfoximine (BSO), but not ethacrynic acid (EA).	Iron	148-150	insulin like growth factor 1	Homo sapiens	62-90
12828522-1	2003	When suspecting an iron overload condition, the transferrin saturation levels should be determined.	Iron	19-23	transferrin	Homo sapiens	48-59
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Iron	13-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-124
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Iron	13-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	196-206
12806962-6	2003	For example, iron controls the oxygen response of HIF-1 activity by two mechanisms; in cytosol, the half life of HIF-1 alpha is determined by hydroxylation of Pro, and transcriptional activity of HIF1 alpha in nuclei is disturbed by hydroxylation of Asn.	Iron	13-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
12729727-3	2003	We report a novel heterologous system for the expression of catalytically active iron-containing NI1 NHase in Escherichia coli, involving coexpression with the E. coli GroES and GroEL chaperones.	Iron	81-85	GroEL	Escherichia coli	178-183
12778774-2	2003	Oxidative stress and carbonyl stress of uremia, dialysis procedure and/or intravenous iron therapy result in AGE (advanced glycation end-product), ALE (advanced lipoxidation end-product) and AOPP (advanced oxidation protein product) formation, favouring together with elevated CRP (C-reactive protein) levels the development of cardiovascular and cerebrovascular complications.	Iron	86-90	C-reactive protein	Homo sapiens	277-280
12778774-2	2003	Oxidative stress and carbonyl stress of uremia, dialysis procedure and/or intravenous iron therapy result in AGE (advanced glycation end-product), ALE (advanced lipoxidation end-product) and AOPP (advanced oxidation protein product) formation, favouring together with elevated CRP (C-reactive protein) levels the development of cardiovascular and cerebrovascular complications.	Iron	86-90	C-reactive protein	Homo sapiens	282-300
12667060-0	2003	Investigation of the mechanism of iron release from the C-lobe of human serum transferrin: mutational analysis of the role of a pH sensitive triad.	Iron	34-38	transferrin	Homo sapiens	78-89
12591920-0	2003	Iron regulatory protein 2 as iron sensor.	Iron	29-33	iron responsive element binding protein 2	Homo sapiens	0-25
12591920-2	2003	Iron regulatory protein 2 coordinates cellular regulation of iron metabolism by binding to iron responsive elements in mRNA.	Iron	61-65	iron responsive element binding protein 2	Homo sapiens	0-25
12591920-2	2003	Iron regulatory protein 2 coordinates cellular regulation of iron metabolism by binding to iron responsive elements in mRNA.	Iron	91-95	iron responsive element binding protein 2	Homo sapiens	0-25
12667076-5	2003	Similar iron(III)-ligand complexes were formed upon reaction of 1 and several other N-hydroxyguanidines with BH(4)-free full-length iNOS and BH(4)-free nNOS(oxy).	Iron	8-12	nitric oxide synthase 2	Homo sapiens	132-136
12667076-11	2003	Comparison of the spectral and physicochemical properties of the N-hydroxyguanidine complexes of BH(4)-free iNOS(oxy) (type II") with those of the previously described corresponding complexes of microperoxidase (MP-8) suggests that, in both cases, N-hydroxyguanidines bind to iron(III) via their oxygen atom after deprotonation or weakening of the O-H bond.	Iron	276-280	nitric oxide synthase 2	Homo sapiens	108-112
12667060-3	2003	Human serum transferrin (hTF) binds iron in the blood and delivers it to actively dividing cells; through the process of receptor-mediated endocytosis, diferric hTF in the serum (pH approximately 7.4) binds to specific TF receptors on the cell surface and is internalized, whereupon a pH drop in the endosome (pH approximately 5.6) facilitates iron release.	Iron	36-40	transferrin	Homo sapiens	12-23
12667060-3	2003	Human serum transferrin (hTF) binds iron in the blood and delivers it to actively dividing cells; through the process of receptor-mediated endocytosis, diferric hTF in the serum (pH approximately 7.4) binds to specific TF receptors on the cell surface and is internalized, whereupon a pH drop in the endosome (pH approximately 5.6) facilitates iron release.	Iron	344-348	transferrin	Homo sapiens	12-23
12682387-0	2003	fac-Tris(2-ethyl-4-oxo-4H-pyran-3-olato-kappa2O3,O4)iron(III) and its aluminium(III) analog.	Iron	52-56	FA complementation group C	Homo sapiens	0-3
12681966-3	2003	Early iron overload may be assessed by biochemical parameters such as increased transferrin saturation and serum ferritin.	Iron	6-10	transferrin	Homo sapiens	80-91
12651624-0	2003	Expression of E-cadherin and other paracellular junction genes is decreased in iron-loaded hepatocytes.	Iron	79-83	cadherin 1	Homo sapiens	14-24
12651624-6	2003	Iron loading of hepatocytes resulted in decreased E-cadherin promoter activity and subsequently decreased E-cadherin mRNA and protein expression.	Iron	0-4	cadherin 1	Homo sapiens	50-60
12651624-6	2003	Iron loading of hepatocytes resulted in decreased E-cadherin promoter activity and subsequently decreased E-cadherin mRNA and protein expression.	Iron	0-4	cadherin 1	Homo sapiens	106-116
12670985-1	2003	Transferrin-binding protein B (TbpB) is one component of a bipartite receptor in several gram-negative bacterial species that binds host transferrin and mediates the uptake of iron for growth.	Iron	176-180	transferrin	Homo sapiens	0-11
12670985-1	2003	Transferrin-binding protein B (TbpB) is one component of a bipartite receptor in several gram-negative bacterial species that binds host transferrin and mediates the uptake of iron for growth.	Iron	176-180	transferrin	Homo sapiens	137-148
12629548-5	2003	Iron regulatory protein 2 (IRP2), a modulator of iron metabolism, is regulated by iron-induced ubiquitination and degradation.	Iron	49-53	iron responsive element binding protein 2	Homo sapiens	0-25
12675926-6	2003	Levels of cytochrome c were increased while levels of pro-caspase-9 and pro-caspase-3 were decreased in cytosolic fractions of iron-treated hippocampal slice cultures.	Iron	127-131	cytochrome c, somatic	Homo sapiens	10-22
12675926-6	2003	Levels of cytochrome c were increased while levels of pro-caspase-9 and pro-caspase-3 were decreased in cytosolic fractions of iron-treated hippocampal slice cultures.	Iron	127-131	caspase 3	Homo sapiens	72-85
12675926-8	2003	In addition, inhibition of caspase-3 activity by Ac-DEVDcho partially protected cells from iron toxicity.	Iron	91-95	caspase 3	Homo sapiens	27-36
12629548-5	2003	Iron regulatory protein 2 (IRP2), a modulator of iron metabolism, is regulated by iron-induced ubiquitination and degradation.	Iron	49-53	iron responsive element binding protein 2	Homo sapiens	27-31
12629548-5	2003	Iron regulatory protein 2 (IRP2), a modulator of iron metabolism, is regulated by iron-induced ubiquitination and degradation.	Iron	82-86	iron responsive element binding protein 2	Homo sapiens	0-25
12629548-5	2003	Iron regulatory protein 2 (IRP2), a modulator of iron metabolism, is regulated by iron-induced ubiquitination and degradation.	Iron	82-86	iron responsive element binding protein 2	Homo sapiens	27-31
12629548-7	2003	The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem.	Iron	67-71	iron responsive element binding protein 2	Homo sapiens	17-21
12629548-7	2003	The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem.	Iron	67-71	iron responsive element binding protein 2	Homo sapiens	59-63
12629548-7	2003	The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem.	Iron	67-71	iron responsive element binding protein 2	Homo sapiens	59-63
12629548-7	2003	The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem.	Iron	119-123	iron responsive element binding protein 2	Homo sapiens	17-21
12629548-7	2003	The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem.	Iron	119-123	iron responsive element binding protein 2	Homo sapiens	59-63
12629548-7	2003	The oxidation of IRP2 is generated by haem, which binds to IRP2 in iron-rich cells, and by oxygen, indicating that the iron sensing of IRP2 depends on the synthesis and availability of haem.	Iron	119-123	iron responsive element binding protein 2	Homo sapiens	59-63
12486226-0	2003	Binding and release of iron by gel-encapsulated human transferrin: evidence for a conformational search.	Iron	23-27	transferrin	Homo sapiens	54-65
12486226-5	2003	Sol-gel-encapsulated iron-free transferrin samples are prepared by using two protocols.	Iron	21-25	transferrin	Homo sapiens	31-42
18209438-0	2003	Attitude of physicians towards iron supplementation in hemodialysis patients treated with erythropoietin.	Iron	31-35	erythropoietin	Homo sapiens	90-104
12646708-0	2003	The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin.	Iron	42-46	transferrin	Homo sapiens	96-107
18209438-1	2003	This study was performed to evaluate the attitude of the physicians in Saudi Arabia towards iron supplementation in hemodialysis patients treated by recombinant human erythropoietin (r-HuEPO).	Iron	92-96	erythropoietin	Homo sapiens	167-181
12499381-5	2003	AmiE protein expression and amidase enzyme activity were iron-repressed in H. pylori 26695 but constitutive in the isogenic fur mutant.	Iron	57-61	aliphatic amidase	Helicobacter pylori 26695	0-4
12646199-5	2003	Iron chelators have also been reported to stabilize HIF-1 alpha protein and activate HIF-1.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-63
12646199-5	2003	Iron chelators have also been reported to stabilize HIF-1 alpha protein and activate HIF-1.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-57
12646199-6	2003	In this study, we investigated the effects of dibenzoylmethane (DBM), a natural dietary compound and an iron chelator, on HIF-1 pathway.	Iron	104-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-127
12627980-7	2003	The interactions of iron-loaded transferrins with transferrin receptor 1 occur with average dissociation constants of 3 +/- 1 and 5 +/- 1 nM for the only C-site iron-loaded and of 6.0 +/- 0.6 and 7 +/- 0.5 nM for the iron-saturated ST in the absence or presence of CHAPS, respectively.	Iron	20-24	transferrin	Homo sapiens	32-43
12627980-7	2003	The interactions of iron-loaded transferrins with transferrin receptor 1 occur with average dissociation constants of 3 +/- 1 and 5 +/- 1 nM for the only C-site iron-loaded and of 6.0 +/- 0.6 and 7 +/- 0.5 nM for the iron-saturated ST in the absence or presence of CHAPS, respectively.	Iron	161-165	transferrin	Homo sapiens	32-43
12627980-7	2003	The interactions of iron-loaded transferrins with transferrin receptor 1 occur with average dissociation constants of 3 +/- 1 and 5 +/- 1 nM for the only C-site iron-loaded and of 6.0 +/- 0.6 and 7 +/- 0.5 nM for the iron-saturated ST in the absence or presence of CHAPS, respectively.	Iron	161-165	transferrin	Homo sapiens	32-43
12511571-6	2003	Expression of HO-1 was also reduced in human cells when exposed to interferon-gamma or an iron chelator desferrioxamine, each of which induced Bach1 expression.	Iron	90-94	BTB domain and CNC homolog 1	Homo sapiens	143-148
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	23-27	charged multivesicular body protein 2B	Homo sapiens	204-208
12870058-4	2003	There was no significant difference in high-fluorescence reticulocyte and soluble transferrin receptor values between the two groups, but a correlation was observed between high-fluorescence reticulocytes and soluble transferrin receptors in iron-deficiency anemia, probably due to increased receptor synthesis as a response to decreased iron content in erythrocytes.	Iron	242-246	transferrin	Homo sapiens	217-228
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	120-124	charged multivesicular body protein 2B	Homo sapiens	204-208
12429017-0	2003	Modulation of cytochrome c spin states by lipid acyl chains: a continuous-wave electron paramagnetic resonance (CW-EPR) study of haem iron.	Iron	134-138	cytochrome c, somatic	Homo sapiens	14-26
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	120-124	charged multivesicular body protein 2B	Homo sapiens	204-208
12572667-5	2003	When cells were incubated with up to 20 microM of iron, a typical decrease in IRP1 and IRP2 activity was observed.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	87-91
12614218-13	2003	The impaired TNF-alpha transcription in cells from ID subjects indicates that the quality of the immune response is linked to the Fe status of mononuclear cells.	Iron	130-132	tumor necrosis factor	Homo sapiens	13-22
12406888-1	2003	Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR).	Iron	9-13	transferrin	Homo sapiens	72-83
12848962-4	2003	The presence of transferrin receptor on immature, proliferating thymocytes and the inhibition of thymocyte proliferation and differentiation by anti-transferrin receptor antibody highlight the importance of iron to T cell development.	Iron	207-211	transferrin	Homo sapiens	16-27
12848962-4	2003	The presence of transferrin receptor on immature, proliferating thymocytes and the inhibition of thymocyte proliferation and differentiation by anti-transferrin receptor antibody highlight the importance of iron to T cell development.	Iron	207-211	transferrin	Homo sapiens	149-160
12848962-6	2003	The association of the iron transporter NRAMP1 with several autoimmune disorders along with evidence that iron can catalyze the production of cryptic epitopes of several autoantigens, establishes a potential role for iron in the development of autoimmunity.	Iron	23-27	solute carrier family 11 member 1	Homo sapiens	40-46
12779071-2	2003	Patients with hereditary hemochromatosis, a disease characterized by progressive iron overload due, in most cases, to homozygosity for C282Y mutation in the HFE gene, have often decreased insulin sensitivity and release.	Iron	81-85	insulin	Homo sapiens	188-195
12589962-1	2003	Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR).	Iron	0-4	transferrin	Homo sapiens	47-58
12589962-1	2003	Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR).	Iron	74-78	transferrin	Homo sapiens	47-58
12779071-8	2003	(2) The presence of mild iron overload was associated with a lower insulin release.	Iron	25-29	insulin	Homo sapiens	67-74
12634541-8	2003	Amounts of transferrin-bound iron (TRF-[Fe3+]) in whole blood and blood plasma samples were measured using quantitative electron paramagnetic resonance spectroscopy.	Iron	29-33	transferrin	Rattus norvegicus	11-22
12631267-8	2003	Two alternative conformations, rotated 180 degrees around an imaginary iron-catecholamine axis, were found for DA and l-DOPA in PAH and for DA in TH.	Iron	71-75	tyrosine hydroxylase	Homo sapiens	146-148
12651115-1	2003	Human serum transferrin is an essential bilobal protein that transports iron in the circulation for delivery to iron-requiring cells.	Iron	112-116	transferrin	Homo sapiens	12-23
12634541-0	2003	Electron paramagnetic resonance analysis of transferrin-bound iron in animal models of blunt trauma.	Iron	62-66	transferrin	Rattus norvegicus	44-55
12634541-2	2003	The objective of the present research was to assess the effect of iron sequestration in animal models of blunt trauma by means of electron paramagnetic resonance spectroscopy of iron in complex with transferrin, a main iron-transporting protein in blood, and to correlate this effect with the extent of induced injury.	Iron	66-70	transferrin	Rattus norvegicus	199-210
12651115-1	2003	Human serum transferrin is an essential bilobal protein that transports iron in the circulation for delivery to iron-requiring cells.	Iron	72-76	transferrin	Homo sapiens	12-23
12531241-1	2003	Transferrin receptor 1 (TfR1) which mediates uptake of transferrin-bound iron, is essential for life in mammals.	Iron	73-77	transferrin	Homo sapiens	0-11
12531241-1	2003	Transferrin receptor 1 (TfR1) which mediates uptake of transferrin-bound iron, is essential for life in mammals.	Iron	73-77	transferrin	Homo sapiens	55-66
12531241-5	2003	Transferrin receptor 2, like transferrin receptor 1, binds transferrin in a pH-dependent manner (but with 25 times lower affinity) and delivers iron to cells.	Iron	144-148	transferrin	Homo sapiens	29-40
12643995-3	2003	It was proposed that T. brucei has developed multiple expression sites encoding different transferrin receptors not only to cope with the diversity of mammalian transferrins, but also to ensure sufficient iron uptake in the presence of anti-transferrin receptor antibodies.	Iron	205-209	transferrin	Homo sapiens	90-101
12592010-1	2003	Regulated expression of proteins involved in mammalian iron metabolism is achieved in part through the interaction of the iron regulatory proteins IRP1 and IRP2 with highly conserved RNA stem-loop structures, known as iron-responsive elements (IREs), that are located within the 5" or 3" untranslated regions of regulated transcripts.	Iron	55-59	iron responsive element binding protein 2	Homo sapiens	156-160
12592010-1	2003	Regulated expression of proteins involved in mammalian iron metabolism is achieved in part through the interaction of the iron regulatory proteins IRP1 and IRP2 with highly conserved RNA stem-loop structures, known as iron-responsive elements (IREs), that are located within the 5" or 3" untranslated regions of regulated transcripts.	Iron	122-126	iron responsive element binding protein 2	Homo sapiens	156-160
12592010-1	2003	Regulated expression of proteins involved in mammalian iron metabolism is achieved in part through the interaction of the iron regulatory proteins IRP1 and IRP2 with highly conserved RNA stem-loop structures, known as iron-responsive elements (IREs), that are located within the 5" or 3" untranslated regions of regulated transcripts.	Iron	122-126	iron responsive element binding protein 2	Homo sapiens	156-160
12657433-2	2003	Patients exhibit predictable changes in iron homeostasis, including elevations in both transferrin saturation and serum ferritin levels.	Iron	40-44	transferrin	Homo sapiens	87-98
12593855-4	2003	Heme oxygenase 1 (HO-1) is an enzyme which degrades heme into biliverdin, free iron, and carbon monoxide (CO).	Iron	79-83	heme oxygenase 1	Mus musculus	0-16
12593855-4	2003	Heme oxygenase 1 (HO-1) is an enzyme which degrades heme into biliverdin, free iron, and carbon monoxide (CO).	Iron	79-83	heme oxygenase 1	Mus musculus	18-22
12606055-0	2003	Role of iron and ferritin in TNFalpha-induced apoptosis in HeLa cells.	Iron	8-12	tumor necrosis factor	Homo sapiens	29-37
12606055-1	2003	We found that tumor necrosis factor alpha (TNFalpha)-induced apoptosis in HeLa cells was accompanied by a approximately 2-fold increase in H- and L-ferritin and a decrease in transferrin receptor, two indices of increased iron availability.	Iron	222-226	tumor necrosis factor	Homo sapiens	14-41
12661755-6	2003	The expression of integrin beta1, neither N-cadherin nor alpha/beta-catenin, was also significantly increased by iron.	Iron	113-117	integrin subunit beta 1	Rattus norvegicus	18-32
12606055-1	2003	We found that tumor necrosis factor alpha (TNFalpha)-induced apoptosis in HeLa cells was accompanied by a approximately 2-fold increase in H- and L-ferritin and a decrease in transferrin receptor, two indices of increased iron availability.	Iron	222-226	tumor necrosis factor	Homo sapiens	43-51
12458193-0	2003	The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin.	Iron	50-54	transferrin	Homo sapiens	94-105
12606055-2	2003	Iron supplementation and overexpression of H-ferritin or its mutant with an inactivated ferroxidase center reduced by about approximately 50% the number of apoptotic cells after TNFalpha-treatment, while overexpression of L-ferritin was ineffective.	Iron	0-4	tumor necrosis factor	Homo sapiens	178-186
12458193-2	2003	Human serum transferrin (hTF) is a bilobal iron-binding and transport protein that carries iron in the blood stream for delivery to cells by a pH-dependent mechanism.	Iron	43-47	transferrin	Homo sapiens	12-23
12458193-2	2003	Human serum transferrin (hTF) is a bilobal iron-binding and transport protein that carries iron in the blood stream for delivery to cells by a pH-dependent mechanism.	Iron	91-95	transferrin	Homo sapiens	12-23
12388178-9	2003	Rats fed FE developed fatty liver, necrosis, and inflammation, which was accompanied by activation of NF-kappaB and the induction of cytokines, chemokines, COX-2, iNOS, and nitrotyrosine formation.	Iron	9-11	nitric oxide synthase 2	Rattus norvegicus	163-167
18968918-12	2003	Al and Fe were presumably bound to transferrin, but due to its low concentration in spent CAPD fluids, it was not possible to confirm its presence in the separated fractions.	Iron	7-9	transferrin	Homo sapiens	35-46
12628581-4	2003	Earlier studies have shown that aniline exposure in rats leads to excessive deposition of iron and increased lipid peroxidation in the spleen, which may produce changes in the expression of fibrogenic cytokines, such as transforming growth factor-beta 1 (TGF-beta 1), leading to splenic fibrosis.	Iron	90-94	transforming growth factor, beta 1	Rattus norvegicus	220-253
12719607-6	2003	The serum transferrin receptor-to-serum ferritin ratio in the low-iron stores group was significantly greater than that of the control group.	Iron	66-70	transferrin	Homo sapiens	10-21
12540406-6	2003	After treatment, serum iron and transferrin saturation increased significantly in the iron group (P = 0.02 and P = 0.03, respectively).	Iron	86-90	transferrin	Homo sapiens	32-43
12540492-9	2003	An iron chelator (phytic acid or deferoxamine) or a hydroxyl radical scavenger (sodium benzoate) each blocked asbestos-induced reductions in deltapsi(m) and caspase 9 activation, suggesting a role for iron-derived ROS.	Iron	3-7	caspase 9	Rattus norvegicus	157-166
12719607-8	2003	Iron supplementation significantly increased hemoglobin, hematocrit, and serum ferritin concentrations and significantly decreased the serum transferrin receptor concentration and serum transferrin receptor:serum ferritin ratio in the low-iron-stores group posttreatment compared to pretreatment.	Iron	0-4	transferrin	Homo sapiens	141-152
12719607-8	2003	Iron supplementation significantly increased hemoglobin, hematocrit, and serum ferritin concentrations and significantly decreased the serum transferrin receptor concentration and serum transferrin receptor:serum ferritin ratio in the low-iron-stores group posttreatment compared to pretreatment.	Iron	0-4	transferrin	Homo sapiens	186-197
12530944-9	2003	Excess hepatic iron may occur in insulin resistance-associated iron overload (IRHIO), characterized by hyperferritinemia with normal to mild increases in transferrin saturation.	Iron	15-19	insulin	Homo sapiens	33-40
12667008-0	2003	Increased serum soluble transferrin receptor concentration detects subclinical iron deficiency in healthy adolescent girls.	Iron	79-83	transferrin	Homo sapiens	24-35
12667008-10	2003	This study shows that, similarly to adults, soluble transferrin receptor measurement can be used to detect subclinical iron deficiency in adolescents (competitive athletes or normal controls).	Iron	119-123	transferrin	Homo sapiens	52-63
12530944-9	2003	Excess hepatic iron may occur in insulin resistance-associated iron overload (IRHIO), characterized by hyperferritinemia with normal to mild increases in transferrin saturation.	Iron	15-19	transferrin	Homo sapiens	154-165
12530944-9	2003	Excess hepatic iron may occur in insulin resistance-associated iron overload (IRHIO), characterized by hyperferritinemia with normal to mild increases in transferrin saturation.	Iron	63-67	insulin	Homo sapiens	33-40
12530944-9	2003	Excess hepatic iron may occur in insulin resistance-associated iron overload (IRHIO), characterized by hyperferritinemia with normal to mild increases in transferrin saturation.	Iron	63-67	transferrin	Homo sapiens	154-165
12589565-1	2003	Using experimentally calibrated density functional calculations on models of the active site of soybean lipoxygenase 1 (SLO-1), insight has been obtained into the coordination flexibility of the iron active site and its molecular mechanism of catalysis.	Iron	195-199	seed linoleate 13S-lipoxygenase-1	Glycine max	104-118
12557137-4	2003	RESULTS: Among patients with compensated liver disease, the presence of HFE mutations was independently associated with elevations in serum iron level, serum transferrin-iron saturation, serum ferritin level, and hepatic iron index (P &lt; 0.05).	Iron	170-174	transferrin	Homo sapiens	158-169
12557137-4	2003	RESULTS: Among patients with compensated liver disease, the presence of HFE mutations was independently associated with elevations in serum iron level, serum transferrin-iron saturation, serum ferritin level, and hepatic iron index (P &lt; 0.05).	Iron	170-174	transferrin	Homo sapiens	158-169
12725261-1	2003	OBJECTIVES: To compare oral versus intravenous iron in pre-dialysis patients of chronic renal failure (CRF) receiving recombinant human erythropoietin (rHuEPO).	Iron	47-51	erythropoietin	Homo sapiens	136-150
12725261-10	2003	The ferrokinetic studies revealed that serum iron, serum ferritin and transferrin saturation, decreased significantly in oral iron group, whereas significant increase was seen in group B (intravenous iron group).	Iron	126-130	transferrin	Homo sapiens	70-81
12725261-10	2003	The ferrokinetic studies revealed that serum iron, serum ferritin and transferrin saturation, decreased significantly in oral iron group, whereas significant increase was seen in group B (intravenous iron group).	Iron	126-130	transferrin	Homo sapiens	70-81
12608554-1	2003	BACKGROUND: The evaluation of iron status in dialysis patients provides information essential to the planning of adequate recombinant human erythropoietin (rHuEPO) treatment.	Iron	30-34	erythropoietin	Homo sapiens	140-154
12565812-5	2003	In the present study we examined the in vivo effects of lipoic acid treatment on Fe metabolism in cultured lens epithelial cells, and found that LA decreases Fe uptake from transferrin, increases Fe deposition into ferritin and increases the concentration of this protein.	Iron	158-160	transferrin	Homo sapiens	173-184
12565812-5	2003	In the present study we examined the in vivo effects of lipoic acid treatment on Fe metabolism in cultured lens epithelial cells, and found that LA decreases Fe uptake from transferrin, increases Fe deposition into ferritin and increases the concentration of this protein.	Iron	158-160	transferrin	Homo sapiens	173-184
12682431-0	2003	Induction of interleukin-6 by coal containing bioavailable iron is through both hydroxyl radical and ferryl species.	Iron	59-63	interleukin 6	Homo sapiens	13-26
12682431-10	2003	Our results indicate that BAI in the PA coal may induce IL-6 through both ferryl species (via iron autoxidation) and hydroxyl radicals (via the Fenton/Haber Weiss reactions).	Iron	94-98	interleukin 6	Homo sapiens	56-60
12608731-0	2003	Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats.	Iron	81-85	transferrin	Rattus norvegicus	19-30
12620681-7	2003	However, all bismuth binds to albumin when iron-saturated transferrin was used.	Iron	43-47	transferrin	Homo sapiens	58-69
12543894-1	2003	BACKGROUND: Optimal response to recombinant human erythropoietin (rHuEpo) in haemodialysis (HD) patients requires provision of sufficient available iron.	Iron	148-152	erythropoietin	Homo sapiens	50-64
12608731-1	2003	The mechanism of the regulation of transferrin (Tf) and transferrin receptor (TfR) levels in rat brain by dietary iron status is not fully elucidated.	Iron	114-118	transferrin	Rattus norvegicus	35-46
12624523-3	2003	In about 70% of patients with multiple myeloma, recombinant human erythropoietin (r-HuEPO) leads to a reduction in transfusion frequency, resulting in a drop in transfusion- related side-effects like infections and immune reactions, iron overload and hyperviscosity which often negatively influence the course of disease.	Iron	233-237	erythropoietin	Homo sapiens	66-80
12608731-1	2003	The mechanism of the regulation of transferrin (Tf) and transferrin receptor (TfR) levels in rat brain by dietary iron status is not fully elucidated.	Iron	114-118	transferrin	Rattus norvegicus	48-50
12608731-3	2003	In a region-specific fashion, iron-deficient diet decreased significantly brain iron concentration by 22-63%, and increased Tf level by 22-130% and TfR level by 74% in thalamus and 40% in cortex.	Iron	30-34	transferrin	Rattus norvegicus	124-126
12608731-8	2003	This capacity may be associated with increased iron-Tf uptake from plasma, stabilization of TfR mRNA, or increased Tf mRNA translation efficiency in specific cell types within the brain.	Iron	47-51	transferrin	Rattus norvegicus	52-54
14515162-2	2003	It was found that the heme iron in ferric cytochrome c does not react directly with peroxynitrite.	Iron	27-31	cytochrome c, somatic	Homo sapiens	42-54
12438312-0	2003	Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans.	Iron	50-54	Ferritin	Caenorhabditis elegans	24-32
12435735-10	2003	Nrf2 may also play a role in basal transcription of both ferritin H and L. These results provide a mechanistic link between regulation of the iron storage protein ferritin and the cancer chemopreventive response.	Iron	142-146	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
12435735-10	2003	Nrf2 may also play a role in basal transcription of both ferritin H and L. These results provide a mechanistic link between regulation of the iron storage protein ferritin and the cancer chemopreventive response.	Iron	142-146	ferritin mitochondrial	Mus musculus	57-67
12495809-8	2003	Iron ions up-regulated EC-SOD synthesis but also blocked the secretion of the enzyme.	Iron	0-4	superoxide dismutase 3	Homo sapiens	23-29
12438312-10	2003	While mammalian ferritin H and L mRNAs are translationally regulated by iron, the amounts of C. elegans ftn-1 and ftn-2 mRNAs are increased by iron and decreased by iron chelation.	Iron	72-76	Ferritin	Caenorhabditis elegans	16-24
12438312-10	2003	While mammalian ferritin H and L mRNAs are translationally regulated by iron, the amounts of C. elegans ftn-1 and ftn-2 mRNAs are increased by iron and decreased by iron chelation.	Iron	143-147	Ferritin	Caenorhabditis elegans	114-119
12438312-10	2003	While mammalian ferritin H and L mRNAs are translationally regulated by iron, the amounts of C. elegans ftn-1 and ftn-2 mRNAs are increased by iron and decreased by iron chelation.	Iron	143-147	Ferritin	Caenorhabditis elegans	114-119
12673348-1	2003	Heme oxygenase-1 (HO-1), an inducible enzyme degrading heme to biliverdin, iron and carbon monoxide, is involved in regulation of inflammation and angiogenesis.	Iron	75-79	heme oxygenase 1	Mus musculus	0-16
12673348-1	2003	Heme oxygenase-1 (HO-1), an inducible enzyme degrading heme to biliverdin, iron and carbon monoxide, is involved in regulation of inflammation and angiogenesis.	Iron	75-79	heme oxygenase 1	Mus musculus	18-22
12393745-2	2003	The hypoxia-inducible factor-1 (HIF-1) transcriptionally up-regulates erythropoietin, transferrin, and transferrin receptor, leading to increased erythropoiesis and hematopoietic iron supply.	Iron	179-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-30
14753484-8	2003	Thrombin formation after an ICH may be part of a signaling cascade that acts to limit potentially injurious events associated with clot resolution through altering iron-handling proteins.	Iron	164-168	coagulation factor II, thrombin	Homo sapiens	0-8
12393745-2	2003	The hypoxia-inducible factor-1 (HIF-1) transcriptionally up-regulates erythropoietin, transferrin, and transferrin receptor, leading to increased erythropoiesis and hematopoietic iron supply.	Iron	179-183	transferrin	Homo sapiens	103-114
12393745-2	2003	The hypoxia-inducible factor-1 (HIF-1) transcriptionally up-regulates erythropoietin, transferrin, and transferrin receptor, leading to increased erythropoiesis and hematopoietic iron supply.	Iron	179-183	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-37
12393745-2	2003	The hypoxia-inducible factor-1 (HIF-1) transcriptionally up-regulates erythropoietin, transferrin, and transferrin receptor, leading to increased erythropoiesis and hematopoietic iron supply.	Iron	179-183	erythropoietin	Homo sapiens	70-84
12393745-2	2003	The hypoxia-inducible factor-1 (HIF-1) transcriptionally up-regulates erythropoietin, transferrin, and transferrin receptor, leading to increased erythropoiesis and hematopoietic iron supply.	Iron	179-183	transferrin	Homo sapiens	86-97
12566661-2	2003	Loosely-bound iron definitely appears in the bloodstream when substantial doses of IV iron are administered, since transferrin is fully saturated, but our investigations generally do not show short-term oxidant stress from this treatment.	Iron	14-18	transferrin	Homo sapiens	115-126
12542499-0	2003	Circadian variations of transferrin saturation levels in iron-overloaded patients: implications for the screening of C282Y-linked haemochromatosis.	Iron	57-61	transferrin	Homo sapiens	24-35
12393528-6	2003	At the start of treatment, ALT (R(2) = 0.64, P =.006) and AST activity (R(2) = 0.57, P =.01) were closely related to urinary iron excretion, reflecting the size of the chelatable or the labile iron pool.	Iron	125-129	solute carrier family 17 member 5	Homo sapiens	58-61
12566661-2	2003	Loosely-bound iron definitely appears in the bloodstream when substantial doses of IV iron are administered, since transferrin is fully saturated, but our investigations generally do not show short-term oxidant stress from this treatment.	Iron	86-90	transferrin	Homo sapiens	115-126
12566661-3	2003	If small doses of IV iron are utilized, transferrin saturation can be avoided, and risk is minimized.	Iron	21-25	transferrin	Homo sapiens	40-51
14514981-9	2003	This case report supports the combination of EPO and IV iron supplementation in patients with anemia of chronic disease and either an impaired iron absorption or intolerance to oral iron.	Iron	143-147	erythropoietin	Homo sapiens	45-48
12507977-0	2003	Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity.	Iron	6-10	transferrin	Homo sapiens	50-61
12647284-12	2003	CONCLUSIONS: Our data demonstrate that dialysis patients with CRP greater than 15 mg/L require an erythropoietin dose approximately 40% higher than patients with normal CRP, both in the presence and absence of iron deficiency.	Iron	210-214	erythropoietin	Homo sapiens	98-112
12647284-13	2003	Iron therapy in patients with normal CRP and tSAT &lt; 20% significantly improved the response to erythropoietin, but was completely ineffective in patients with increased CRP.	Iron	0-4	C-reactive protein	Homo sapiens	37-40
12647284-13	2003	Iron therapy in patients with normal CRP and tSAT &lt; 20% significantly improved the response to erythropoietin, but was completely ineffective in patients with increased CRP.	Iron	0-4	erythropoietin	Homo sapiens	98-112
12647284-14	2003	These results suggest that functional iron deficiency plays a marginal role in resistance to erythropoietin observed in patients with elevated CRP concentrations.	Iron	38-42	erythropoietin	Homo sapiens	93-107
12647284-14	2003	These results suggest that functional iron deficiency plays a marginal role in resistance to erythropoietin observed in patients with elevated CRP concentrations.	Iron	38-42	C-reactive protein	Homo sapiens	143-146
12589110-0	2003	Disproportionately elevated fasting proinsulin levels in normoglycemic patients with thalassemia major are correlated to the degree of iron overload.	Iron	135-139	insulin	Homo sapiens	36-46
12589110-1	2003	OBJECTIVE: To analyze the secretion of the insulin precursor proinsulin in patients with beta-thalassemia and its possible relation to iron overload.	Iron	135-139	insulin	Homo sapiens	43-50
12589110-1	2003	OBJECTIVE: To analyze the secretion of the insulin precursor proinsulin in patients with beta-thalassemia and its possible relation to iron overload.	Iron	135-139	insulin	Homo sapiens	61-71
12806184-2	2003	We have demonstrated an important role of cytochrome P450 (CYP) as a significant source of catalytic iron in this model of NS.	Iron	101-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-57
12806184-2	2003	We have demonstrated an important role of cytochrome P450 (CYP) as a significant source of catalytic iron in this model of NS.	Iron	101-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	59-62
14580938-2	2003	In order for the brain to obtain iron, transferrin receptors are present in the vascular endothelial cell to facilitate movement of transferrin bound iron into the brain parenchyma.	Iron	33-37	serotransferrin	Bos taurus	39-50
14580938-2	2003	In order for the brain to obtain iron, transferrin receptors are present in the vascular endothelial cell to facilitate movement of transferrin bound iron into the brain parenchyma.	Iron	33-37	serotransferrin	Bos taurus	132-143
14580938-5	2003	In this study, we have used fluorescein-transferrin-59Fe in a bovine retinal endothelial cell culture system to determine the mechanism of transferrin-iron transport and to test the hypothesis that the iron status of the endothelial cells would influence iron transport.	Iron	151-155	serotransferrin	Bos taurus	139-150
14580938-5	2003	In this study, we have used fluorescein-transferrin-59Fe in a bovine retinal endothelial cell culture system to determine the mechanism of transferrin-iron transport and to test the hypothesis that the iron status of the endothelial cells would influence iron transport.	Iron	202-206	serotransferrin	Bos taurus	139-150
14580938-5	2003	In this study, we have used fluorescein-transferrin-59Fe in a bovine retinal endothelial cell culture system to determine the mechanism of transferrin-iron transport and to test the hypothesis that the iron status of the endothelial cells would influence iron transport.	Iron	202-206	serotransferrin	Bos taurus	139-150
14580938-7	2003	The ratio of non-transferrin-bound iron to transferrin-bound iron transported is dependent upon the iron status of the cells.	Iron	35-39	serotransferrin	Bos taurus	17-28
14580938-7	2003	The ratio of non-transferrin-bound iron to transferrin-bound iron transported is dependent upon the iron status of the cells.	Iron	61-65	serotransferrin	Bos taurus	43-54
14580938-7	2003	The ratio of non-transferrin-bound iron to transferrin-bound iron transported is dependent upon the iron status of the cells.	Iron	61-65	serotransferrin	Bos taurus	43-54
14580938-8	2003	Blocking acidification of endosomes led to a significant decrease in transport of non-transferrin-bound iron but not transferrin-bound iron.	Iron	104-108	serotransferrin	Bos taurus	86-97
14580938-10	2003	These results indicate that there is both transferrin-mediated and non-transferrin-mediated transcytosis of iron and that the process is influenced by the iron status of the cells.	Iron	108-112	serotransferrin	Bos taurus	42-53
14580938-10	2003	These results indicate that there is both transferrin-mediated and non-transferrin-mediated transcytosis of iron and that the process is influenced by the iron status of the cells.	Iron	108-112	serotransferrin	Bos taurus	71-82
15100465-1	2003	In previous work, guided ion beam tandem mass spectrometry has been used to study the reactions of the cluster cations of several transition metals (V, Cr, Fe and Ni) with D2, O2, CO2 and CD4.	Iron	156-158	CD4 molecule	Homo sapiens	188-191
14671617-3	2003	Abnormal iron parameters were defined as transferrin saturation (TS) &gt;50% or &gt;45% and serum ferritin (SF) &gt;300 or &gt;250 microg/ml in males and females, respectively.	Iron	9-13	transferrin	Homo sapiens	41-52
15160548-6	2003	CONCLUSION: In patients with persistently low hemoglobin values, optimizing urea clearance and a proactive approach to intravenous iron therapy may enhance epoetin responsiveness.	Iron	131-135	erythropoietin	Homo sapiens	156-163
15160549-4	2003	RESULTS: The administration of EPO was associated with an increased serum creatinine (11.9 +/- 0.4 to 12.5 +/- 0.4 mg/dl, p &lt; 0.05), insulin-like growth factor binding protein (3.0 +/- 0.2 to 3.4 +/- 0.2 micrograms/ml, p &lt; 0.05) as well as decreased iron level (112 +/- 7 to 88 +/- 7 micrograms/dl, p &lt; 0.005).	Iron	256-260	erythropoietin	Homo sapiens	31-34
12480973-12	2003	Prescription of IV iron and IV Epo were associated with higher Epo/Hb index.	Iron	19-23	erythropoietin	Homo sapiens	63-66
14716026-6	2003	Both normal and ApoE-/- mice displayed some cognitive impairment when deprived of folate and vitamin E and exposed to iron, but ApoE-/- mice were more severely affected.	Iron	118-122	apolipoprotein E	Mus musculus	16-20
12509560-5	2003	Serum ferritin, iron, and transferrin iron saturation levels were highest and transferrin level lowest in the patients with the highest liver iron content.	Iron	38-42	transferrin	Homo sapiens	26-37
12509560-5	2003	Serum ferritin, iron, and transferrin iron saturation levels were highest and transferrin level lowest in the patients with the highest liver iron content.	Iron	38-42	transferrin	Homo sapiens	26-37
12862222-0	2003	Enhancing oxidation of TNT and RDX in wastewater: pre-treatment with elemental iron.	Iron	79-83	chromosome 16 open reading frame 82	Homo sapiens	23-26
12862222-5	2003	The objective of this work is to investigate the feasibility of using elemental iron to convert TNT and RDX to reduction products which may be more oxidizable in subsequent Fenton"s oxidation.	Iron	80-84	chromosome 16 open reading frame 82	Homo sapiens	96-99
12862222-6	2003	Results of batch reduction experiments with elemental iron showed complete removal of TNT and RDX and formation of the reduction products within 60 minutes.	Iron	54-58	chromosome 16 open reading frame 82	Homo sapiens	86-89
12862222-8	2003	Fitting observed effluent concentrations to a one-dimensional advection-dispersion equation, we were able to predict the concentration profiles of TNT and RDX in the iron column and calculate the iron column length required for the desired removal.	Iron	166-170	chromosome 16 open reading frame 82	Homo sapiens	147-150
12862222-9	2003	The results of Fenton"s oxidation experiments showed that iron pre-treatment enhanced both the rate and extent of TNT and RDX mineralization by Fenton"s oxidation.	Iron	58-62	chromosome 16 open reading frame 82	Homo sapiens	114-117
12446481-2	2002	It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin.	Iron	87-91	haptoglobin	Homo sapiens	47-58
12485992-3	2002	We propose that disconnection is mediated by a change in the physical properties of PSI-K in PSI in response to a change in plastid Fe content, which is sensed through the occupancy, and hence activity, of the Fe-containing active site in Crd1.	Iron	132-134	CORD1	Homo sapiens	239-243
12485992-3	2002	We propose that disconnection is mediated by a change in the physical properties of PSI-K in PSI in response to a change in plastid Fe content, which is sensed through the occupancy, and hence activity, of the Fe-containing active site in Crd1.	Iron	210-212	CORD1	Homo sapiens	239-243
12657244-0	2002	Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death.	Iron	37-41	mitogen-activated protein kinase 14	Homo sapiens	15-18
12657244-4	2002	Among three MAP kinase blockers used, however, the selective p38 MAP kinase inhibitor SB203580 could only protect HL-60 cells from chelator-induced cell death, indicating that p38 MAP kinase serves as a major mediator of apoptosis induced by iron chelator.	Iron	242-246	mitogen-activated protein kinase 14	Homo sapiens	61-64
12657244-4	2002	Among three MAP kinase blockers used, however, the selective p38 MAP kinase inhibitor SB203580 could only protect HL-60 cells from chelator-induced cell death, indicating that p38 MAP kinase serves as a major mediator of apoptosis induced by iron chelator.	Iron	242-246	mitogen-activated protein kinase 14	Homo sapiens	176-179
12657244-7	2002	Collectively, the current study reveals that p38 MAP kinase plays an important role in iron chelator-mediated cell death of HL-60 cells by activating downstream apoptotic cascade that executes cell death pathway.	Iron	87-91	mitogen-activated protein kinase 14	Homo sapiens	45-59
12450380-1	2002	The mammalian iron-binding proteins lactoferrin (Lf) and transferrin (Tf) bind iron very tightly, but reversibly.	Iron	14-18	transferrin	Homo sapiens	57-68
12450380-1	2002	The mammalian iron-binding proteins lactoferrin (Lf) and transferrin (Tf) bind iron very tightly, but reversibly.	Iron	14-18	transferrin	Homo sapiens	70-72
12450380-1	2002	The mammalian iron-binding proteins lactoferrin (Lf) and transferrin (Tf) bind iron very tightly, but reversibly.	Iron	79-83	transferrin	Homo sapiens	57-68
12450380-1	2002	The mammalian iron-binding proteins lactoferrin (Lf) and transferrin (Tf) bind iron very tightly, but reversibly.	Iron	79-83	transferrin	Homo sapiens	70-72
12450380-2	2002	Despite homologous structures and essentially identical iron binding sites, Tf begins to release iron at pH 6.0, whereas Lf retains iron to pH approximately 3.5.	Iron	97-101	transferrin	Homo sapiens	76-78
12450380-2	2002	Despite homologous structures and essentially identical iron binding sites, Tf begins to release iron at pH 6.0, whereas Lf retains iron to pH approximately 3.5.	Iron	97-101	transferrin	Homo sapiens	76-78
12450380-4	2002	Two lysine residues, Lys 206 and Lys 296, which form a hydrogen-bonded dilysine pair in human Tf, have been shown to strongly influence iron release from the N-lobe.	Iron	136-140	transferrin	Homo sapiens	94-96
12450380-11	2002	Three specific sites are variably occupied by polar groups in the Lf mutants and other Lf and Tf proteins, and when coupled with iron-release data, these give new insights into the factors that most influence iron retention at low pH.	Iron	129-133	transferrin	Homo sapiens	94-96
12450380-11	2002	Three specific sites are variably occupied by polar groups in the Lf mutants and other Lf and Tf proteins, and when coupled with iron-release data, these give new insights into the factors that most influence iron retention at low pH.	Iron	209-213	transferrin	Homo sapiens	94-96
12460029-17	2002	Cross-sectional survey results of iron studies suggest the relationship between iron studies and erythropoietin is modified by confounding.	Iron	34-38	erythropoietin	Homo sapiens	97-111
12460029-17	2002	Cross-sectional survey results of iron studies suggest the relationship between iron studies and erythropoietin is modified by confounding.	Iron	80-84	erythropoietin	Homo sapiens	97-111
12480173-5	2002	However, ApoE knockout mice accumulated significantly increased TBARs following iron challenge when folic acid was withheld, and accumulated even more TBARs when both folic acid and vitamin E were withheld.	Iron	80-84	apolipoprotein E	Mus musculus	9-13
12480173-6	2002	These findings demonstrate that ApoE knockout mice during vitamin deficiency are less capable of buffering the consequences of dietary iron challenge than are normal mice.	Iron	135-139	apolipoprotein E	Mus musculus	32-36
12446481-2	2002	It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin.	Iron	124-128	haptoglobin	Homo sapiens	47-58
12446481-8	2002	CONCLUSIONS: The effect of haptoglobin type on iron homeostasis cannot account for the marked phenotypic variation that is seen in patients homozygous for the HFE C282Y mutation.	Iron	47-51	haptoglobin	Homo sapiens	27-38
12459033-1	2002	Transferrin (Tf) is an iron transport protein expressed in MCF-7 human breast cancer cells.	Iron	23-27	transferrin	Homo sapiens	0-11
12426360-9	2002	Correspondingly, genes with increased expression in the transferrin and ferritin experiments were expressed at reduced levels when hemoglobin was supplied as the sole iron source.	Iron	167-171	non-heme ferritin	Pasteurella multocida	72-80
12480800-7	2002	Mean serum transferrin receptor concentrations and the serum transferrin receptor to ferritin ratios significantly decreased in the iron depleted group following supplementation (6.1 +/- 1.6 mg/L to 4.6 +/- 1.5 mg/L and 890 +/- 753 to 198 +/- 114, respectively).	Iron	132-136	transferrin	Homo sapiens	11-22
12480800-7	2002	Mean serum transferrin receptor concentrations and the serum transferrin receptor to ferritin ratios significantly decreased in the iron depleted group following supplementation (6.1 +/- 1.6 mg/L to 4.6 +/- 1.5 mg/L and 890 +/- 753 to 198 +/- 114, respectively).	Iron	132-136	transferrin	Homo sapiens	61-72
12459033-1	2002	Transferrin (Tf) is an iron transport protein expressed in MCF-7 human breast cancer cells.	Iron	23-27	transferrin	Homo sapiens	13-15
12480903-1	2002	To get a better insight into the physiology of the high-toxic JP2 clone of Actinobacillus actinomycetemcomitans serotype b, which is strongly associated with juvenile periodontitis in adolescents of African descent, the modes of iron acquisition in this clone were examined and compared to those of other strains of the species.	Iron	229-233	T cell receptor gamma joining P2	Homo sapiens	62-65
12468600-10	2002	In conclusion, our data suggest that DADS could modify iron homeostasis through the modulation of ferritin and transferrin receptor gene expression.	Iron	55-59	transferrin	Rattus norvegicus	111-122
12480903-5	2002	Thus, A. actinomycetemcomitans seems to be in a process of evolution, in which iron acquisition from host transferrin is not essential as in many other members of the pasteurellaceae.	Iron	79-83	transferrin	Homo sapiens	106-117
12198135-0	2002	An iron-responsive element type II in the 5"-untranslated region of the Alzheimer"s amyloid precursor protein transcript.	Iron	3-7	amyloid beta precursor protein	Homo sapiens	84-109
12429868-1	2002	The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.	Iron	110-114	transferrin	Rattus norvegicus	13-24
12429868-1	2002	The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.	Iron	110-114	transferrin	Rattus norvegicus	92-103
12429868-1	2002	The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.	Iron	175-179	transferrin	Rattus norvegicus	13-24
12429868-1	2002	The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.	Iron	175-179	transferrin	Rattus norvegicus	92-103
12437345-12	2002	We, therefore, conclude that Gln360 primarily regulates the ET reaction of P450(cam) by modulating the redox potential of the heme iron and not by the specific interaction with Pdx or the formation of the ET pathway that are proposed as the regulation mechanism of Arg112.	Iron	131-135	calmodulin 3	Homo sapiens	75-84
12596608-4	2002	Since iron is needed for Hgb synthesis, iron depletion exacerbated anemia and reduces the response to recombinant erythropoietin (rEPO) therapy.	Iron	40-44	erythropoietin	Homo sapiens	114-128
12198135-2	2002	We mapped a novel iron-responsive element (IRE-Type II) within the 5"-untranslated region (5"-UTR) of the Alzheimer"s amyloid precursor protein (APP) transcript (+51 to +94 from the 5"-cap site).	Iron	18-22	amyloid beta precursor protein	Homo sapiens	118-143
12547217-0	2002	Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?	Iron	92-96	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	34-66
12393650-9	2002	Exposure of human TFR-2(+) cells to TF-bound iron is followed by a significant up-regulation and relocalization of membrane TFR-2.	Iron	45-49	transferrin	Homo sapiens	18-20
12393650-10	2002	The tissue distribution pattern, the behavior following exposure to iron-loaded TF, and the features of the disease resulting from TFR-2 inactivation support the hypothesis that TFR-2 contributes to body iron sensing.	Iron	68-72	transferrin	Homo sapiens	80-82
12200453-0	2002	Multiple, conserved iron-responsive elements in the 3"-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2.	Iron	20-24	iron responsive element binding protein 2	Homo sapiens	123-148
12200453-1	2002	Synthesis of proteins for iron homeostasis is regulated by specific, combinatorial mRNA/protein interactions between RNA stem-loop structures (iron-responsive elements, IREs) and iron-regulatory proteins (IRP1 and IRP2), controlling either mRNA translation or stability.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	214-218
12406099-1	2002	Myeloablative treatment results in iron accumulation and the appearance of non-transferrin-bound iron (NTBI) in the circulation, which may contribute to treatment-related organ damage and susceptibility to infections.	Iron	97-101	transferrin	Homo sapiens	79-90
12547229-9	2002	The uptake of transferrin-bound iron and expression of functional TfR1 was shown to occur mainly in crypt cells and to be proportional to the plasma concentration of iron.	Iron	32-36	transferrin	Rattus norvegicus	14-25
12547229-9	2002	The uptake of transferrin-bound iron and expression of functional TfR1 was shown to occur mainly in crypt cells and to be proportional to the plasma concentration of iron.	Iron	166-170	transferrin	Rattus norvegicus	14-25
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	119-123	transferrin	Homo sapiens	25-36
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	136-140	transferrin	Homo sapiens	25-36
12407636-1	2002	BACKGROUND: We hypothesized that intravenous iron will improve hemoglobin (Hgb) concentrations in anemic patients with chronic kidney disease (CKD), and the response would be greater if the underlying erythropoietin deficiency also was treated.	Iron	45-49	erythropoietin	Homo sapiens	201-215
12407643-7	2002	Univariate comparisons between subjects with or without elevated CRP levels (&gt;10 mg/L) showed that CRP level elevation was associated significantly (P &lt; 0.05) with greater doses of human recombinant erythropoietin and lower levels of hemoglobin, serum iron, transferrin saturation (TSat), albumin averaged over the 3 preceding months, total cholesterol, and triglycerides.	Iron	258-262	C-reactive protein	Homo sapiens	102-105
12547229-3	2002	In the crypts the cells take up iron from plasma transferrin by receptor-mediated endocytosis, a process that is influenced by the hemochromatosis protein, HFE.	Iron	32-36	transferrin	Rattus norvegicus	49-60
12547229-4	2002	Hence, the availability of plasma transferrin-bound iron and the expression and function of transferrin receptors (TfR1), HFE and DMT1 should all contribute to the absorptive capacity of villus enterocytes.	Iron	52-56	transferrin	Rattus norvegicus	34-45
12547229-6	2002	In most experiments the function of the TfR1 was assessed by the uptake of radiolabeled transferrin-bound iron given intravenously.	Iron	106-110	transferrin	Rattus norvegicus	88-99
12547240-5	2002	SFT is characterized by its ability to increase iron transport both through the transferrin dependent and independent uptake, and could thus affect iron absorption in the intestine.	Iron	48-52	transferrin	Homo sapiens	80-91
12547217-0	2002	Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?	Iron	92-96	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	68-73
12393231-2	2002	In this study we found that both neurotrophin-4 (NT-4) and basic fibroblast growth factor (bFGF) potentiated necrotic neuronal death caused by exposure to oxygen-glucose deprivation or iron-citrate (Fe) in cortical cultures.	Iron	199-201	neurotrophin 4	Homo sapiens	33-47
12393231-2	2002	In this study we found that both neurotrophin-4 (NT-4) and basic fibroblast growth factor (bFGF) potentiated necrotic neuronal death caused by exposure to oxygen-glucose deprivation or iron-citrate (Fe) in cortical cultures.	Iron	199-201	neurotrophin 4	Homo sapiens	49-53
12547217-1	2002	Quantitative genetic analysis of hepatic and splenic iron levels in recombinant inbred mice yielded a quantitative trait locus that was found to coincide with the genomic locale encompassing the tumor necrosis factor receptor 2 gene (Tnfr2).	Iron	53-57	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	195-227
12393231-2	2002	In this study we found that both neurotrophin-4 (NT-4) and basic fibroblast growth factor (bFGF) potentiated necrotic neuronal death caused by exposure to oxygen-glucose deprivation or iron-citrate (Fe) in cortical cultures.	Iron	199-201	fibroblast growth factor 2	Homo sapiens	59-89
12393231-2	2002	In this study we found that both neurotrophin-4 (NT-4) and basic fibroblast growth factor (bFGF) potentiated necrotic neuronal death caused by exposure to oxygen-glucose deprivation or iron-citrate (Fe) in cortical cultures.	Iron	199-201	fibroblast growth factor 2	Homo sapiens	91-95
12547217-1	2002	Quantitative genetic analysis of hepatic and splenic iron levels in recombinant inbred mice yielded a quantitative trait locus that was found to coincide with the genomic locale encompassing the tumor necrosis factor receptor 2 gene (Tnfr2).	Iron	53-57	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	234-239
12547217-2	2002	When fed an iron-enriched diet, mice nullizygous with respect to Tnfr2, but not the Tnfr1 gene, showed a significant increase in splenic non-heme iron levels.	Iron	12-16	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	65-70
12547217-2	2002	When fed an iron-enriched diet, mice nullizygous with respect to Tnfr2, but not the Tnfr1 gene, showed a significant increase in splenic non-heme iron levels.	Iron	146-150	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	65-70
12547217-6	2002	These results suggest that HFE and TNFR2 are both involved in regulating iron deposition in tissues and that the regulation occurs at the level of the intestine through IEL-orchestrated production of TNF following the binding to TNFR2.	Iron	73-77	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	35-40
12547217-6	2002	These results suggest that HFE and TNFR2 are both involved in regulating iron deposition in tissues and that the regulation occurs at the level of the intestine through IEL-orchestrated production of TNF following the binding to TNFR2.	Iron	73-77	tumor necrosis factor	Mus musculus	35-38
12547217-7	2002	These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron.	Iron	80-84	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	32-37
12547217-7	2002	These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron.	Iron	140-144	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	32-37
12547221-1	2002	In mammalian iron metabolism, ferritin, transferrin receptor and several other iron metabolism genes are post-transcriptionally regulated.	Iron	13-17	transferrin	Homo sapiens	40-51
12547221-1	2002	In mammalian iron metabolism, ferritin, transferrin receptor and several other iron metabolism genes are post-transcriptionally regulated.	Iron	79-83	transferrin	Homo sapiens	40-51
12553165-2	2002	The significance of the iron for brain function is reflected by the presence of receptors for transferrin on brain capillary endothelial cells.	Iron	24-28	transferrin	Rattus norvegicus	94-105
12553165-4	2002	Whereas there is good agreement that iron is taken up by means of receptor-mediated uptake of iron-transferrin at the brain barriers, there are contradictory views on how iron is transported further on from the brain barriers and into the brain extracellular space.	Iron	37-41	transferrin	Rattus norvegicus	99-110
12553165-13	2002	Accordingly, it was concluded that the paramount iron transport across the BBB is the result of receptor-mediated endocytosis of iron-containing transferrin by capillary endothelial cells, followed by recycling of transferrin to the blood and transport of non-transferrin-bound iron into the brain.	Iron	129-133	transferrin	Rattus norvegicus	145-156
12553165-4	2002	Whereas there is good agreement that iron is taken up by means of receptor-mediated uptake of iron-transferrin at the brain barriers, there are contradictory views on how iron is transported further on from the brain barriers and into the brain extracellular space.	Iron	94-98	transferrin	Rattus norvegicus	99-110
12553165-20	2002	As the choroid plexus is known to synthesize transferrin, a key question is whether transferrin of the CSF might play a role for iron homeostasis by diffusing from the ventricles and subarachnoid space to the brain interstitium.	Iron	129-133	transferrin	Rattus norvegicus	84-95
12553165-32	2002	Related to these observations, the presence of non-transferrin-bound iron in the brain suggests that glial cells may take it up by a mechanism that does not involve the transferrin receptor.	Iron	69-73	transferrin	Rattus norvegicus	51-62
12553165-4	2002	Whereas there is good agreement that iron is taken up by means of receptor-mediated uptake of iron-transferrin at the brain barriers, there are contradictory views on how iron is transported further on from the brain barriers and into the brain extracellular space.	Iron	94-98	transferrin	Rattus norvegicus	99-110
12553165-39	2002	For reasons mentioned above, transferrin of the CSF is of little significance for transport and cellular delivery of iron to transferrin receptor-expressing neurons.	Iron	117-121	transferrin	Rattus norvegicus	125-136
12553165-40	2002	Instead, transferrin of the CSF probably plays a significant role for neutralization and export to the blood of metals, including iron.	Iron	130-134	transferrin	Rattus norvegicus	9-20
12553165-5	2002	The prevailing hypothesis for transport of iron across the BBB suggests a mechanism that involves detachment of iron from transferrin within barrier cells followed by recycling of apo-transferrin to blood plasma and release of iron as non-transferrin-bound iron into the brain interstitium from where the iron is taken up by neurons and glial cells.	Iron	43-47	transferrin	Rattus norvegicus	122-133
12553165-43	2002	A developing regulated transfer of iron to the brain was reflected morphologically by a higher content of transferrin receptors and non-heme iron in endothelial cells of the developing rat brain than in the adult.	Iron	35-39	transferrin	Rattus norvegicus	106-117
12553165-5	2002	The prevailing hypothesis for transport of iron across the BBB suggests a mechanism that involves detachment of iron from transferrin within barrier cells followed by recycling of apo-transferrin to blood plasma and release of iron as non-transferrin-bound iron into the brain interstitium from where the iron is taken up by neurons and glial cells.	Iron	43-47	transferrin	Rattus norvegicus	184-195
12553165-5	2002	The prevailing hypothesis for transport of iron across the BBB suggests a mechanism that involves detachment of iron from transferrin within barrier cells followed by recycling of apo-transferrin to blood plasma and release of iron as non-transferrin-bound iron into the brain interstitium from where the iron is taken up by neurons and glial cells.	Iron	43-47	transferrin	Rattus norvegicus	184-195
12553165-5	2002	The prevailing hypothesis for transport of iron across the BBB suggests a mechanism that involves detachment of iron from transferrin within barrier cells followed by recycling of apo-transferrin to blood plasma and release of iron as non-transferrin-bound iron into the brain interstitium from where the iron is taken up by neurons and glial cells.	Iron	112-116	transferrin	Rattus norvegicus	122-133
12553165-5	2002	The prevailing hypothesis for transport of iron across the BBB suggests a mechanism that involves detachment of iron from transferrin within barrier cells followed by recycling of apo-transferrin to blood plasma and release of iron as non-transferrin-bound iron into the brain interstitium from where the iron is taken up by neurons and glial cells.	Iron	112-116	transferrin	Rattus norvegicus	122-133
12553165-5	2002	The prevailing hypothesis for transport of iron across the BBB suggests a mechanism that involves detachment of iron from transferrin within barrier cells followed by recycling of apo-transferrin to blood plasma and release of iron as non-transferrin-bound iron into the brain interstitium from where the iron is taken up by neurons and glial cells.	Iron	112-116	transferrin	Rattus norvegicus	122-133
12553165-5	2002	The prevailing hypothesis for transport of iron across the BBB suggests a mechanism that involves detachment of iron from transferrin within barrier cells followed by recycling of apo-transferrin to blood plasma and release of iron as non-transferrin-bound iron into the brain interstitium from where the iron is taken up by neurons and glial cells.	Iron	112-116	transferrin	Rattus norvegicus	122-133
12553165-6	2002	Another hypothesis claims that iron-transferrin is transported into the brain by means of transcytosis through the BBB.	Iron	31-35	transferrin	Rattus norvegicus	36-47
12553165-9	2002	The transport of iron and transport into the brain was examined using radiolabeled iron-transferrin.	Iron	83-87	transferrin	Rattus norvegicus	88-99
12553165-12	2002	It was estimated that the iron-binding capacity of transferrin in CSF was exceeded, suggesting that iron is transported into the brain in a quantity that exceeds that of transferrin.	Iron	26-30	transferrin	Rattus norvegicus	51-62
12553165-12	2002	It was estimated that the iron-binding capacity of transferrin in CSF was exceeded, suggesting that iron is transported into the brain in a quantity that exceeds that of transferrin.	Iron	100-104	transferrin	Rattus norvegicus	51-62
12553165-13	2002	Accordingly, it was concluded that the paramount iron transport across the BBB is the result of receptor-mediated endocytosis of iron-containing transferrin by capillary endothelial cells, followed by recycling of transferrin to the blood and transport of non-transferrin-bound iron into the brain.	Iron	49-53	transferrin	Rattus norvegicus	145-156
12553165-13	2002	Accordingly, it was concluded that the paramount iron transport across the BBB is the result of receptor-mediated endocytosis of iron-containing transferrin by capillary endothelial cells, followed by recycling of transferrin to the blood and transport of non-transferrin-bound iron into the brain.	Iron	49-53	transferrin	Rattus norvegicus	214-225
12553165-13	2002	Accordingly, it was concluded that the paramount iron transport across the BBB is the result of receptor-mediated endocytosis of iron-containing transferrin by capillary endothelial cells, followed by recycling of transferrin to the blood and transport of non-transferrin-bound iron into the brain.	Iron	49-53	transferrin	Rattus norvegicus	214-225
12553165-13	2002	Accordingly, it was concluded that the paramount iron transport across the BBB is the result of receptor-mediated endocytosis of iron-containing transferrin by capillary endothelial cells, followed by recycling of transferrin to the blood and transport of non-transferrin-bound iron into the brain.	Iron	129-133	transferrin	Rattus norvegicus	145-156
12465072-1	2002	Mice with targeted disruptions in the iron-responsive binding protein 2 (IRP2) gene accumulate iron in distinct regions of the brain and develop neurodegenerative characteristics resembling Parkinson"s disease after 6 months of age.	Iron	38-42	iron responsive element binding protein 2	Homo sapiens	73-77
12356906-9	2002	Colocalization studies with transferrin identified this organelle as the endocytic recycling compartment via which iron-depleted transferrin exits the cell.	Iron	115-119	transferrin	Homo sapiens	28-39
12356906-9	2002	Colocalization studies with transferrin identified this organelle as the endocytic recycling compartment via which iron-depleted transferrin exits the cell.	Iron	115-119	transferrin	Homo sapiens	129-140
12470799-3	2002	However, there is now compelling evidence that Abeta does not spontaneously aggregate, but that there is an age-dependent reaction with excess brain metal (copper, iron and zinc), which induces the protein to precipitate into metal-enriched masses (plaques).	Iron	164-168	amyloid beta precursor protein	Homo sapiens	47-52
12356639-2	2002	We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II-induced renal damage.	Iron	105-109	angiotensinogen	Rattus norvegicus	62-76
12161425-3	2002	MTP1, the duodenal enterocyte basolateral iron exporter, is also expressed in the cells of the reticuloendothelial system (RES) and is likely to be involved in iron recycling of these cells.	Iron	42-46	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-4
12161425-3	2002	MTP1, the duodenal enterocyte basolateral iron exporter, is also expressed in the cells of the reticuloendothelial system (RES) and is likely to be involved in iron recycling of these cells.	Iron	160-164	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-4
12363398-7	2002	Significant higher levels of glutamate, IL-6 and TNF-alpha were observed in the group with iron intake (peak values were obtained at 6, 8 and 4 h, respectively).	Iron	91-95	interleukin 6	Rattus norvegicus	40-44
12363398-7	2002	Significant higher levels of glutamate, IL-6 and TNF-alpha were observed in the group with iron intake (peak values were obtained at 6, 8 and 4 h, respectively).	Iron	91-95	tumor necrosis factor	Rattus norvegicus	49-58
12223357-0	2002	The transcytosis of divalent metal transporter 1 and apo-transferrin during iron uptake in intestinal epithelium.	Iron	76-80	transferrin	Homo sapiens	57-68
12223357-2	2002	Caco-2 cells exhibit constitutive transport of iron from the apical (luminal) chamber to the basal (serosal) chamber that is enhanced by apo-transferrin in the basal chamber, with the apo-transferrin undergoing endocytosis to the apical portion of the cell.	Iron	47-51	transferrin	Homo sapiens	141-152
12223357-2	2002	Caco-2 cells exhibit constitutive transport of iron from the apical (luminal) chamber to the basal (serosal) chamber that is enhanced by apo-transferrin in the basal chamber, with the apo-transferrin undergoing endocytosis to the apical portion of the cell.	Iron	47-51	transferrin	Homo sapiens	188-199
12223357-4	2002	These findings suggest that in Caco-2 cells DMT1 and apo-transferrin may cooperate in iron transport through transcytosis.	Iron	86-90	transferrin	Homo sapiens	57-68
12223357-5	2002	To prove this hypothesis, we determined by confocal microscopy that, after addition of iron to the apical chamber, DMT1 from the BBM and Texas red apo-transferrin from the basal chamber colocalized in a perinuclear compartment.	Iron	87-91	transferrin	Homo sapiens	151-162
12356639-0	2002	Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation.	Iron	0-4	angiotensinogen	Rattus norvegicus	23-37
12374293-1	2002	IRT1 and IRT2 are members of the Arabidopsis ZIP metal transporter family that are specifically induced by iron deprivation in roots and act as heterologous suppressors of yeast mutations inhibiting iron and zinc uptake.	Iron	107-111	iron regulated transporter 2	Arabidopsis thaliana	9-13
12374293-1	2002	IRT1 and IRT2 are members of the Arabidopsis ZIP metal transporter family that are specifically induced by iron deprivation in roots and act as heterologous suppressors of yeast mutations inhibiting iron and zinc uptake.	Iron	199-203	iron regulated transporter 2	Arabidopsis thaliana	9-13
12430092-4	2002	In CKD patients, parenteral iron administered with recombinant human erythropoietin (rHuEpo), is the best potential option for the correction of anemia.	Iron	28-32	erythropoietin	Homo sapiens	69-83
12161425-9	2002	We hypothesize that the iron sequestration in the RES system that accompanies inflammation is because of down-regulation of MTP1.	Iron	24-28	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	124-128
12374623-6	2002	However, combined treatment with folate deprivation and dietary iron depleted antioxidant capacity and induced oxidative damage in ApoE-deficient brains despite increased glutathione, indicating an inability to compensate for the lack of ApoE under these conditions.	Iron	64-68	apolipoprotein E	Mus musculus	131-135
12138088-3	2002	Grx5 is involved in iron/sulfur cluster assembly at the mitochondria, but the function of Grx3 and Grx4 is unknown.	Iron	20-24	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	0-4
12242109-5	2002	In addition, Fe depletion may also inhibit the newly identified p53-inducible form of this molecule called p53R2.	Iron	13-15	ribonucleotide reductase M2 B (TP53 inducible)	Mus musculus	107-112
12269814-2	2002	Chemical shift perturbations observed for cytochrome b(5) amide resonances upon complex formation with either metmyoglobin (Fe(III)) or carbon monoxide-bound myoglobin (Fe(II)) are more than 10-fold smaller than in other transient redox protein complexes.	Iron	124-126	cytochrome b5 type A	Bos taurus	42-57
12476940-0	2002	Total iron binding capacity and transferrin concentration in the assessment of iron status.	Iron	79-83	transferrin	Homo sapiens	32-43
12476940-1	2002	Transferrin concentration and total iron binding capacity (TIBC) are currently used to assess iron status.	Iron	94-98	transferrin	Homo sapiens	0-11
12476940-4	2002	Due to binding of iron to other plasma proteins (mainly albumin), TIBC methods generally overestimate the iron binding capacity of transferrin.	Iron	106-110	transferrin	Homo sapiens	131-142
12356639-2	2002	We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II-induced renal damage.	Iron	105-109	angiotensinogen	Rattus norvegicus	185-199
12356639-3	2002	In the present study, we investigated the role of iron in the development of cardiac injury induced by angiotensin II.	Iron	50-54	angiotensinogen	Rattus norvegicus	103-117
12356639-5	2002	No iron deposits were observed in the hearts of untreated rats, whereas iron deposition was seen in the cells in the subepicardial and granulation regions after angiotensin II infusion.	Iron	72-76	angiotensinogen	Rattus norvegicus	161-175
12356639-6	2002	Concomitant administration of deferoxamine, an iron chelator, significantly reduced the extent of cardiac fibrosis, which suggests that iron deposition aggravates the cardiac fibrosis induced by angiotensin II.	Iron	47-51	angiotensinogen	Rattus norvegicus	195-209
12356639-6	2002	Concomitant administration of deferoxamine, an iron chelator, significantly reduced the extent of cardiac fibrosis, which suggests that iron deposition aggravates the cardiac fibrosis induced by angiotensin II.	Iron	136-140	angiotensinogen	Rattus norvegicus	195-209
12356639-7	2002	Iron overload caused by the administration of iron-dextran resulted in an augmentation of cardiac fibrosis and the generation of neointimal cells in the coronary artery in angiotensin II-infused rats.	Iron	0-4	angiotensinogen	Rattus norvegicus	172-186
12356639-9	2002	CONCLUSIONS: Cardiac iron deposition may be involved in the development of cardiac fibrosis induced by angiotensin II.	Iron	21-25	angiotensinogen	Rattus norvegicus	103-117
12356639-10	2002	In addition, iron overload may enhance the formation of neointima under conditions of increased circulating angiotensin II but not catecholamines.	Iron	13-17	angiotensinogen	Rattus norvegicus	108-122
12638935-4	2002	A major factor contributing to suboptimal correction of renal anaemia and reduced responsiveness to epoetin is a lack of iron availability to the stimulated erythropoesis.Thus, forthe majority of patients with renal insufficiency intravenous iron therapy will be the treatment of choice to replete and maintain adequate iron stores.	Iron	121-125	erythropoietin	Homo sapiens	100-107
12465840-4	2002	Dechlorination of PCE and TCE by iron and zinc in the presence of vitamin B12 showed that the zinc and vitamin B12 combination greatly enhances the reaction rates for both PCE and TCE, but iron and vitamin B12 result in an increase in reactivity only for PCE degradation, not for TCE degradation in comparison with metals only.	Iron	33-37	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	111-114
12465840-4	2002	Dechlorination of PCE and TCE by iron and zinc in the presence of vitamin B12 showed that the zinc and vitamin B12 combination greatly enhances the reaction rates for both PCE and TCE, but iron and vitamin B12 result in an increase in reactivity only for PCE degradation, not for TCE degradation in comparison with metals only.	Iron	33-37	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	111-114
12465840-2	2002	UV-visible spectra showed that zinc reduces vitamin B12 Co(III) to vitamin B12 Co(I) through B12 Co(II) and iron reduces vitamin B12 Co(III) to vitamin B12 Co(II).	Iron	108-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
12465840-2	2002	UV-visible spectra showed that zinc reduces vitamin B12 Co(III) to vitamin B12 Co(I) through B12 Co(II) and iron reduces vitamin B12 Co(III) to vitamin B12 Co(II).	Iron	108-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
12465840-2	2002	UV-visible spectra showed that zinc reduces vitamin B12 Co(III) to vitamin B12 Co(I) through B12 Co(II) and iron reduces vitamin B12 Co(III) to vitamin B12 Co(II).	Iron	108-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
12465840-4	2002	Dechlorination of PCE and TCE by iron and zinc in the presence of vitamin B12 showed that the zinc and vitamin B12 combination greatly enhances the reaction rates for both PCE and TCE, but iron and vitamin B12 result in an increase in reactivity only for PCE degradation, not for TCE degradation in comparison with metals only.	Iron	189-193	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	74-77
12465840-2	2002	UV-visible spectra showed that zinc reduces vitamin B12 Co(III) to vitamin B12 Co(I) through B12 Co(II) and iron reduces vitamin B12 Co(III) to vitamin B12 Co(II).	Iron	108-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
12465840-4	2002	Dechlorination of PCE and TCE by iron and zinc in the presence of vitamin B12 showed that the zinc and vitamin B12 combination greatly enhances the reaction rates for both PCE and TCE, but iron and vitamin B12 result in an increase in reactivity only for PCE degradation, not for TCE degradation in comparison with metals only.	Iron	189-193	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	111-114
12465840-4	2002	Dechlorination of PCE and TCE by iron and zinc in the presence of vitamin B12 showed that the zinc and vitamin B12 combination greatly enhances the reaction rates for both PCE and TCE, but iron and vitamin B12 result in an increase in reactivity only for PCE degradation, not for TCE degradation in comparison with metals only.	Iron	189-193	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	111-114
12638935-4	2002	A major factor contributing to suboptimal correction of renal anaemia and reduced responsiveness to epoetin is a lack of iron availability to the stimulated erythropoesis.Thus, forthe majority of patients with renal insufficiency intravenous iron therapy will be the treatment of choice to replete and maintain adequate iron stores.	Iron	242-246	erythropoietin	Homo sapiens	100-107
12638935-4	2002	A major factor contributing to suboptimal correction of renal anaemia and reduced responsiveness to epoetin is a lack of iron availability to the stimulated erythropoesis.Thus, forthe majority of patients with renal insufficiency intravenous iron therapy will be the treatment of choice to replete and maintain adequate iron stores.	Iron	242-246	erythropoietin	Homo sapiens	100-107
12455693-4	2002	A cDNA, Fer1, encoding ferritin for iron storage also was identified.	Iron	36-40	uncharacterized protein	Chlamydomonas reinhardtii	8-12
12455693-8	2002	Fox1 is most highly related to the mammalian homologues hephaestin and ceruloplasmin; its occurrence and pattern of expression in Chlamydomonas indicate, for the first time, a role for copper in iron assimilation in a photosynthetic species.	Iron	195-199	RNA binding fox-1 homolog 1	Homo sapiens	0-4
12382198-4	2002	Wild-type HFE protein binds to the transferrin receptor, and by an undefined mechanism the enterocyte is "programmed" to absorb an amount of dietary iron precisely matched to the body"s needs.	Iron	149-153	transferrin	Homo sapiens	35-46
12416729-3	2002	The function of HFE protein is unknown, but the available evidence suggests that it acts in association with beta2-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	168-172	transferrin	Homo sapiens	133-144
12416729-3	2002	The function of HFE protein is unknown, but the available evidence suggests that it acts in association with beta2-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	168-172	transferrin	Homo sapiens	192-203
12416730-4	2002	When cellular iron is abundant, IRPs become inactivated (IRP-1) or degraded (IRP-2).	Iron	14-18	iron responsive element binding protein 2	Homo sapiens	77-82
12416731-1	2002	The transferrin receptor is an essential component of cellular uptake of iron, and it binds to serum transferrin.	Iron	73-77	transferrin	Homo sapiens	4-15
12416731-1	2002	The transferrin receptor is an essential component of cellular uptake of iron, and it binds to serum transferrin.	Iron	73-77	transferrin	Homo sapiens	101-112
12416732-9	2002	Mitochondrial respiratory enzymes and plasma membrane enzymes such as sodium-potassium-adenosine triphosphatase (Na(+) + K(+)-ATPase) may be key targets of damage by non-transferrin-bound iron in cardiac myocytes.	Iron	188-192	transferrin	Homo sapiens	170-181
12416732-14	2002	Hepatic DNA of iron-loaded patients shows evidence of damage, including mutations of the tumor suppressor gene p53.	Iron	15-19	tumor protein p53	Homo sapiens	111-114
12368396-3	2002	The acute phase response, defined by raised CRP (plasma concentration &gt;10 mg/L), raised AGP (&gt;1.2 g/L), or both raised CRP and AGP, significantly affected indicators of iron, vitamin A and zinc status, independently of the effects of supplementation.	Iron	175-179	C-reactive protein	Homo sapiens	44-47
12368396-3	2002	The acute phase response, defined by raised CRP (plasma concentration &gt;10 mg/L), raised AGP (&gt;1.2 g/L), or both raised CRP and AGP, significantly affected indicators of iron, vitamin A and zinc status, independently of the effects of supplementation.	Iron	175-179	C-reactive protein	Homo sapiens	125-128
12368427-7	2002	Azole drugs coordinated tightly to the haem iron in M. tuberculosis H37Rv P450s encoded by genes Rv0764c (the sterol demethylase CYP51) and Rv2276 (CYP121).	Iron	44-48	lanosterol 14-alpha demethylase	Mycobacterium tuberculosis H37Rv	129-134
12368427-7	2002	Azole drugs coordinated tightly to the haem iron in M. tuberculosis H37Rv P450s encoded by genes Rv0764c (the sterol demethylase CYP51) and Rv2276 (CYP121).	Iron	44-48	cytochrome P450 Cyp121	Mycobacterium tuberculosis H37Rv	148-154
12368452-2	2002	It has been demonstrated that PvdS plays a role in the iron-dependent regulation of exotoxin A (ETA) in Pseudomonas aeruginosa strain PAO1.	Iron	55-59	exotoxin A	Pseudomonas aeruginosa PAO1	84-94
12368452-2	2002	It has been demonstrated that PvdS plays a role in the iron-dependent regulation of exotoxin A (ETA) in Pseudomonas aeruginosa strain PAO1.	Iron	55-59	exotoxin A	Pseudomonas aeruginosa PAO1	96-99
12382200-6	2002	A dramatic decrease in the synthesis of the plasma iron transport protein, transferrin, leads to a massive accumulation of iron in nonhematopoietic tissues but virtually no iron is available for erythropoiesis.	Iron	51-55	transferrin	Homo sapiens	75-86
12382200-6	2002	A dramatic decrease in the synthesis of the plasma iron transport protein, transferrin, leads to a massive accumulation of iron in nonhematopoietic tissues but virtually no iron is available for erythropoiesis.	Iron	123-127	transferrin	Homo sapiens	75-86
12382200-6	2002	A dramatic decrease in the synthesis of the plasma iron transport protein, transferrin, leads to a massive accumulation of iron in nonhematopoietic tissues but virtually no iron is available for erythropoiesis.	Iron	123-127	transferrin	Homo sapiens	75-86
12382200-13	2002	Homozygous heme oxygenase 1 deletion in mice leads to a paradoxical accumulation of nonheme iron in macrophages, hepatocytes, and many other cells and is associated with low plasma iron levels, anemia, endothelial cell damage, and decreased resistance to oxidative stress.	Iron	92-96	heme oxygenase 1	Mus musculus	11-27
12382200-13	2002	Homozygous heme oxygenase 1 deletion in mice leads to a paradoxical accumulation of nonheme iron in macrophages, hepatocytes, and many other cells and is associated with low plasma iron levels, anemia, endothelial cell damage, and decreased resistance to oxidative stress.	Iron	181-185	heme oxygenase 1	Mus musculus	11-27
12382200-24	2002	The defect in PANK2 is predicted to cause the accumulation of cysteine, which binds iron and causes oxidative stress in the iron-rich globus pallidus.	Iron	84-88	pantothenate kinase 2	Homo sapiens	14-19
12382200-24	2002	The defect in PANK2 is predicted to cause the accumulation of cysteine, which binds iron and causes oxidative stress in the iron-rich globus pallidus.	Iron	124-128	pantothenate kinase 2	Homo sapiens	14-19
12095998-0	2002	Combinatorial control of yeast FET4 gene expression by iron, zinc, and oxygen.	Iron	55-59	Fet4p	Saccharomyces cerevisiae S288C	31-35
12221295-3	2002	We demonstrate that decreased expression of Nfs1p, the yeast cysteine desulfurase that plays a central role in Fe-S cluster synthesis, also results in mitochondrial iron accumulation due to decreased export of mitochondrial iron.	Iron	111-115	cysteine desulfurase	Saccharomyces cerevisiae S288C	44-49
12221295-3	2002	We demonstrate that decreased expression of Nfs1p, the yeast cysteine desulfurase that plays a central role in Fe-S cluster synthesis, also results in mitochondrial iron accumulation due to decreased export of mitochondrial iron.	Iron	165-169	cysteine desulfurase	Saccharomyces cerevisiae S288C	44-49
12221295-3	2002	We demonstrate that decreased expression of Nfs1p, the yeast cysteine desulfurase that plays a central role in Fe-S cluster synthesis, also results in mitochondrial iron accumulation due to decreased export of mitochondrial iron.	Iron	224-228	cysteine desulfurase	Saccharomyces cerevisiae S288C	44-49
12095998-4	2002	The FET4 gene encodes a low affinity iron and copper uptake transporter.	Iron	37-41	Fet4p	Saccharomyces cerevisiae S288C	4-8
12095998-7	2002	First, we found that FET4 expression is induced in iron-limited cells by the Aft1 iron-responsive transcriptional activator.	Iron	51-55	Fet4p	Saccharomyces cerevisiae S288C	21-25
12095998-7	2002	First, we found that FET4 expression is induced in iron-limited cells by the Aft1 iron-responsive transcriptional activator.	Iron	82-86	Fet4p	Saccharomyces cerevisiae S288C	21-25
12095998-13	2002	Thus, Fet4 is a multisubstrate metal ion transporter under combinatorial control by iron, zinc, and oxygen.	Iron	84-88	Fet4p	Saccharomyces cerevisiae S288C	6-10
12181188-2	2002	This study tested a hypothesis that iron directly elicits the signaling required for activation of NF-kappaB and stimulation of tumor necrosis factor (TNF)-alpha gene expression in Kupffer cells.	Iron	36-40	tumor necrosis factor	Rattus norvegicus	128-161
12181188-8	2002	We propose that this finding offers a molecular basis for iron-mediated accentuation of TNF-alpha-dependent liver injury.	Iron	58-62	tumor necrosis factor	Rattus norvegicus	88-97
11945174-0	2002	Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression.	Iron	0-4	transforming growth factor beta 1	Homo sapiens	94-126
12529982-1	2002	It is known that the interruption of normal iron metabolism with chelators of iron, toxic metals, toxic metals bound to transferrin, or anti-transferrin receptor antibodies leads to significant inhibition of tumor cell growth in cell culture systems and animal models.	Iron	44-48	transferrin	Homo sapiens	120-131
12529982-1	2002	It is known that the interruption of normal iron metabolism with chelators of iron, toxic metals, toxic metals bound to transferrin, or anti-transferrin receptor antibodies leads to significant inhibition of tumor cell growth in cell culture systems and animal models.	Iron	44-48	transferrin	Homo sapiens	141-152
12529982-2	2002	In the present study, we found that iron depletion was produced by the iron chelator deferoxamine mesylate, the free toxic metals gallium or indium, and the toxic metals gallium or indium bound to transferrin in the MCF-7 human breast cancer cell line, and this induced the condensation and fragmentation of chromatin, and the formation of DNA fragments characteristic of apoptosis.	Iron	36-40	transferrin	Homo sapiens	197-208
12529982-2	2002	In the present study, we found that iron depletion was produced by the iron chelator deferoxamine mesylate, the free toxic metals gallium or indium, and the toxic metals gallium or indium bound to transferrin in the MCF-7 human breast cancer cell line, and this induced the condensation and fragmentation of chromatin, and the formation of DNA fragments characteristic of apoptosis.	Iron	71-75	transferrin	Homo sapiens	197-208
11945174-0	2002	Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression.	Iron	0-4	transforming growth factor beta 1	Homo sapiens	128-137
12529982-4	2002	The apoptosis, caused by deferoxamine mesylate, and gallium or indium bound to transferrin in the MCF-7 cells, can be completely inhibited by excess ferric chloride or equimolar iron-loaded transferrin.	Iron	178-182	transferrin	Homo sapiens	79-90
12529982-4	2002	The apoptosis, caused by deferoxamine mesylate, and gallium or indium bound to transferrin in the MCF-7 cells, can be completely inhibited by excess ferric chloride or equimolar iron-loaded transferrin.	Iron	178-182	transferrin	Homo sapiens	190-201
12207838-8	2002	The serum ACE concentration was significantly elevated in the offspring of Fe-restricted dams at 3 but not 14 months of age.	Iron	75-77	angiotensin I converting enzyme	Rattus norvegicus	10-13
12194935-8	2002	Iron dissociated from transferrin by acidic pH reacts with ferrozine to form a colored complex in the final step, and the increase in absorbance at 570/660 nm is directly proportional to the TIBC measured.	Iron	0-4	transferrin	Homo sapiens	22-33
12511994-1	2002	Damages to liposomal membranes resulted from intensification of lipid peroxidation with iron ions in the presence of ascorbate or treatment with the membrane disintegrator tetrachloromethane led to activation of phospholipase A2, which depended on the enzyme localization in liposomes.	Iron	88-92	phospholipase A2 group IB	Homo sapiens	212-228
12230555-0	2002	The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.	Iron	103-107	transferrin	Homo sapiens	39-50
12442073-0	2002	[Should the insulin resistance associated with hepatic iron overload be researched during diabetes mellitus type II?].	Iron	55-59	insulin	Homo sapiens	12-19
12442073-1	2002	The insulin resistance-associated hepatic iron overload is the first aetiology of iron overload disorders in France.	Iron	42-46	insulin	Homo sapiens	4-11
12442073-1	2002	The insulin resistance-associated hepatic iron overload is the first aetiology of iron overload disorders in France.	Iron	82-86	insulin	Homo sapiens	4-11
12192037-0	2002	Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2.	Iron	39-43	Y-box binding protein 1	Homo sapiens	105-109
12198710-0	2002	Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats.	Iron	73-77	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
12198710-1	2002	BACKGROUND &amp; AIMS: Hepcidin is an antimicrobial peptide thought to be involved in the regulation of intestinal iron absorption.	Iron	115-119	hepcidin antimicrobial peptide	Rattus norvegicus	23-31
12198710-8	2002	CONCLUSIONS: This study showed a close relationship between the expression of hepcidin, duodenal iron transporters, and iron absorption.	Iron	97-101	hepcidin antimicrobial peptide	Rattus norvegicus	78-86
12198710-9	2002	Both hepcidin expression and iron absorption can be regulated before iron stores and erythropoiesis are affected, and transferrin saturation may signal such changes.	Iron	69-73	hepcidin antimicrobial peptide	Rattus norvegicus	5-13
12183576-2	2002	We have characterized the function of SIT1 in C. albicans by constructing sit1 deletion strains and testing their virulence and ability to utilize a range of siderophores and other iron complexes.	Iron	181-185	siderophore transporter	Saccharomyces cerevisiae S288C	38-42
12183576-5	2002	Hemin was a source of iron for both sit1 and ftr1 mutants, suggesting a pathway of hemin uptake distinct from that of siderophores and iron salts.	Iron	22-26	siderophore transporter	Saccharomyces cerevisiae S288C	36-40
12183576-9	2002	These results suggest that siderophore uptake by Sit1p/Arn1p is required in a specific process of C. albicans infection, namely epithelial invasion and penetration, while in the blood or within organs other sources of iron, including heme, may be used.	Iron	218-222	siderophore transporter	Saccharomyces cerevisiae S288C	49-54
12164868-2	2002	We have recently shown that cytochrome P450 (CYP) is a significant source of catalytic iron in this model of glomerular injury.	Iron	87-91	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	28-43
12164868-2	2002	We have recently shown that cytochrome P450 (CYP) is a significant source of catalytic iron in this model of glomerular injury.	Iron	87-91	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	45-48
12192037-0	2002	Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2.	Iron	39-43	iron responsive element binding protein 2	Homo sapiens	114-118
12192037-4	2002	Both in vitro binding and coimmunoprecipitation assays showed the direct interaction of YB-1 and IRP2 in the presence of a high concentration of iron.	Iron	145-149	Y-box binding protein 1	Homo sapiens	88-92
12192037-4	2002	Both in vitro binding and coimmunoprecipitation assays showed the direct interaction of YB-1 and IRP2 in the presence of a high concentration of iron.	Iron	145-149	iron responsive element binding protein 2	Homo sapiens	97-101
12192037-5	2002	RNA gel shift assays showed that YB-1 reduced the formation of the IRP2-mRNA complex when the iron-responsive element of the ferritin mRNA 5" untranslated region (UTR) was used as a probe.	Iron	94-98	Y-box binding protein 1	Homo sapiens	33-37
12192037-5	2002	RNA gel shift assays showed that YB-1 reduced the formation of the IRP2-mRNA complex when the iron-responsive element of the ferritin mRNA 5" untranslated region (UTR) was used as a probe.	Iron	94-98	iron responsive element binding protein 2	Homo sapiens	67-71
12187081-3	2002	Recently, the soluble transferrin receptor (s-TfR) has been advocated as a parameter of iron status in HD patients.	Iron	88-92	transferrin	Homo sapiens	22-33
12192037-8	2002	An In vivo coimmunoprecipitation assay showed that IRP2 bound to YB-1 in the presence of iron and a proteasome inhibitor.	Iron	89-93	iron responsive element binding protein 2	Homo sapiens	51-55
12192037-8	2002	An In vivo coimmunoprecipitation assay showed that IRP2 bound to YB-1 in the presence of iron and a proteasome inhibitor.	Iron	89-93	Y-box binding protein 1	Homo sapiens	65-69
12192037-9	2002	The direct interaction of YB-1 and IRP2 provides the first evidence of the involvement of YB-1 in the translational regulation of an iron-related protein.	Iron	133-137	Y-box binding protein 1	Homo sapiens	26-30
12192037-9	2002	The direct interaction of YB-1 and IRP2 provides the first evidence of the involvement of YB-1 in the translational regulation of an iron-related protein.	Iron	133-137	iron responsive element binding protein 2	Homo sapiens	35-39
12192037-9	2002	The direct interaction of YB-1 and IRP2 provides the first evidence of the involvement of YB-1 in the translational regulation of an iron-related protein.	Iron	133-137	Y-box binding protein 1	Homo sapiens	90-94
12160403-5	2002	It is proposed that subsequent chelation of the MoS(4) ligand results in cleavage of an M-micro-SPh bond, initiating a cascade of reactions which lead to the ultimate break-up of the cluster and formation of the products, [S(2)MoS(2)Fe(SPh)(2)](2)(-) or [S(2)MoS(2)CoS(2)MoS(2)](2)(-).	Iron	233-235	surfactant associated 3	Homo sapiens	96-99
12380952-2	2002	Disordered iron metabolism as manifested by a low serum iron, decreased serum transferrin, decreased transferrin saturation, increased serum ferritin, increased reticuloendothelial iron stores, increased erythrocyte-free protoporphyrin, and reduced iron absorption, is a characteristic feature of the anemia of chronic disease and has been thought to be a major factor contributing to the syndrome.	Iron	11-15	transferrin	Homo sapiens	78-89
12380952-2	2002	Disordered iron metabolism as manifested by a low serum iron, decreased serum transferrin, decreased transferrin saturation, increased serum ferritin, increased reticuloendothelial iron stores, increased erythrocyte-free protoporphyrin, and reduced iron absorption, is a characteristic feature of the anemia of chronic disease and has been thought to be a major factor contributing to the syndrome.	Iron	11-15	transferrin	Homo sapiens	101-112
12380952-5	2002	Increased intracellular iron may also have a role in the inhibition of erythropoietin production, since the oxygen sensor is a hemoprotein.	Iron	24-28	erythropoietin	Homo sapiens	71-85
12380952-10	2002	Indeed, it is highly likely that abnormalities such as reduced iron absorption and decreased erythroblast transferrin-receptor expression largely result from decreased erythropoietin production and inhibition of its activity by inflammatory cytokines.	Iron	63-67	erythropoietin	Homo sapiens	168-182
12387362-0	2002	Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun.	Iron	25-29	caspase 3	Homo sapiens	118-127
12387362-0	2002	Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun.	Iron	25-29	tumor protein p53	Homo sapiens	140-143
12165535-0	2002	Multivalent metal-induced iron acquisition from transferrin and lactoferrin by myeloid cells.	Iron	26-30	transferrin	Homo sapiens	48-59
12165535-9	2002	HL-60 cells possess a high-capacity multivalent metal-inducible mechanism for Fe acquisition from transferrin and lactoferrin that bears many similarities to the process previously described that allows these and other cell types to acquire Fe from low-m.w.	Iron	78-80	transferrin	Homo sapiens	98-109
12165535-9	2002	HL-60 cells possess a high-capacity multivalent metal-inducible mechanism for Fe acquisition from transferrin and lactoferrin that bears many similarities to the process previously described that allows these and other cell types to acquire Fe from low-m.w.	Iron	241-243	transferrin	Homo sapiens	98-109
12165551-4	2002	Patients receiving higher doses of IL-10 developed anemia and presented with a dose-dependent increase of ferritin and soluble transferrin receptor levels, an indicator of iron restriction to erythroid progenitor cells.	Iron	172-176	transferrin	Homo sapiens	127-138
12136141-7	2002	The binding constants and the electron-transfer rates between cytochrome b(5) and cytochrome c decrease owing to the mutation, which can be accounted for by molecular modeling: the inter-iron distances increase in order to eliminate the unreasonably close contacts resulting from the large volumes of the mutated side chains.	Iron	187-191	cytochrome c, somatic	Homo sapiens	82-94
12227986-3	2002	Parameters related to iron metabolism, such as serum iron (SI), serum ferritin (SF), and soluble transferrin receptor (sTfR) were correlated to levels of interferon-gamma (IFN-gamma) and results compared to a group of 42 nonanemic patients with HIV.	Iron	22-26	interferon gamma	Homo sapiens	154-170
12124217-1	2002	Heme oxygenase (HO)-1 converts heme to bilirubin, carbon monoxide, and iron.	Iron	71-75	heme oxygenase 1	Mus musculus	0-21
12182756-0	2002	Non-transferrin-bound iron in untreated and ribavirin-treated chronic hepatitis C patients.	Iron	22-26	transferrin	Homo sapiens	4-15
12182756-3	2002	In situations of iron overload, non-transferrin-bound iron can appear.	Iron	17-21	transferrin	Homo sapiens	36-47
12182756-8	2002	Four patients with high non-transferrin-bound iron levels were distinguished by higher serum iron levels.	Iron	46-50	transferrin	Homo sapiens	28-39
12182756-8	2002	Four patients with high non-transferrin-bound iron levels were distinguished by higher serum iron levels.	Iron	93-97	transferrin	Homo sapiens	28-39
12182756-12	2002	Non-transferrin-bound iron levels are only higher than normal in hepatitis C patients with higher serum iron levels.	Iron	22-26	transferrin	Homo sapiens	4-15
12182756-3	2002	In situations of iron overload, non-transferrin-bound iron can appear.	Iron	54-58	transferrin	Homo sapiens	36-47
12230874-5	2002	Chelatable iron levels also influence the induction of ho-1 as evidenced by the inhibitory effects of iron-chelating compounds.	Iron	102-106	heme oxygenase 1	Mus musculus	55-59
12182756-4	2002	Therefore, we determined non-transferrin-bound iron levels in untreated chronic hepatitis C patients and in patients during interferon-ribavirin treatment.	Iron	47-51	transferrin	Homo sapiens	29-40
12182756-5	2002	MATERIALS AND METHODS: In 10 untreated and 19 interferon-ribavirin-treated chronic hepatitis C patients, we examined non-transferrin-bound iron levels by a colorimetric method using nitrilotriacetic acid as a ligand and sodium triscarbonatecobalt (III) to block free iron binding sites on transferrin.	Iron	139-143	transferrin	Homo sapiens	121-132
12201364-0	2002	Cold induces catalytic iron release of cytochrome P-450 origin: a critical step in cold storage-induced renal injury.	Iron	23-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-55
12201364-2	2002	Whether the cytochrome P-450 enzymes, shown to be a source for iron in several injury models, contribute to cold-induced iron release is not known.	Iron	63-67	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	12-28
12201364-2	2002	Whether the cytochrome P-450 enzymes, shown to be a source for iron in several injury models, contribute to cold-induced iron release is not known.	Iron	121-125	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	12-28
12201364-5	2002	As microsomes are rich in iron-containing cytochrome P-450 enzymes, microsomes were cold stored with P-450 inhibitors, cimetidine and piperonyl butoxide.	Iron	26-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-58
12201364-10	2002	Our data demonstrate for the first time that cold-induced catalytic iron release may be at least in part of microsomal cytochrome P-450 origin, and that it participates in cold-storage-induced renal injury.	Iron	68-72	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	119-135
12182756-12	2002	Non-transferrin-bound iron levels are only higher than normal in hepatitis C patients with higher serum iron levels.	Iron	104-108	transferrin	Homo sapiens	4-15
12227986-3	2002	Parameters related to iron metabolism, such as serum iron (SI), serum ferritin (SF), and soluble transferrin receptor (sTfR) were correlated to levels of interferon-gamma (IFN-gamma) and results compared to a group of 42 nonanemic patients with HIV.	Iron	22-26	interferon gamma	Homo sapiens	172-181
12193935-7	2002	Eighteen percent of preeclamptic subjects had percent transferrin saturation levels in the region associated with iron overload.	Iron	114-118	transferrin	Homo sapiens	54-65
12230874-5	2002	Chelatable iron levels also influence the induction of ho-1 as evidenced by the inhibitory effects of iron-chelating compounds.	Iron	11-15	heme oxygenase 1	Mus musculus	55-59
12230874-8	2002	This review will examine the potential roles of iron, glutathione, and reactive oxygen species in the upstream events leading to ho-1 activation following oxygen related stress.	Iron	48-52	heme oxygenase 1	Mus musculus	129-133
12139757-5	2002	The underlying mechanism was an effect of EPO on e-ALAS mRNA translation, which was under the control of iron regulatory proteins (IRP) 1 and 2.	Iron	105-109	erythropoietin	Homo sapiens	42-45
12196170-0	2002	Transferrin-mediated iron acquisition by pathogenic Neisseria.	Iron	21-25	transferrin	Homo sapiens	0-11
12196170-1	2002	The pathogenic Neisseria have a siderophore-independent iron-uptake system reliant on a direct interaction between the bacterial cell and transferrin.	Iron	56-60	transferrin	Homo sapiens	138-149
12196170-3	2002	This short account will review our current knowledge of the transferrin-mediated iron-acquisition system of pathogenic Neisseria.	Iron	81-85	transferrin	Homo sapiens	60-71
12196177-0	2002	Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption.	Iron	32-36	hepcidin antimicrobial peptide	Rattus norvegicus	69-77
12196177-1	2002	Hepcidin is an anti-microbial peptide predicted to be involved in the regulation of intestinal iron absorption.	Iron	95-99	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
12196177-2	2002	We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response.	Iron	108-112	hepcidin antimicrobial peptide	Rattus norvegicus	60-68
12196177-2	2002	We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response.	Iron	248-252	hepcidin antimicrobial peptide	Rattus norvegicus	60-68
12196177-2	2002	We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response.	Iron	248-252	hepcidin antimicrobial peptide	Rattus norvegicus	60-68
12196177-3	2002	In each case, elevated hepcidin expression correlated with reduced iron absorption and depressed levels of iron-transport molecules.	Iron	67-71	hepcidin antimicrobial peptide	Rattus norvegicus	23-31
12196177-3	2002	In each case, elevated hepcidin expression correlated with reduced iron absorption and depressed levels of iron-transport molecules.	Iron	107-111	hepcidin antimicrobial peptide	Rattus norvegicus	23-31
12196177-4	2002	These data are consistent with hepcidin playing a role as a negative regulator of intestinal iron absorption.	Iron	93-97	hepcidin antimicrobial peptide	Rattus norvegicus	31-39
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	Iron	159-161	calmodulin 1	Homo sapiens	94-104
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	Iron	159-161	transferrin	Homo sapiens	188-199
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	Iron	185-187	calmodulin 1	Homo sapiens	94-104
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	Iron	185-187	transferrin	Homo sapiens	188-199
12139757-5	2002	The underlying mechanism was an effect of EPO on e-ALAS mRNA translation, which was under the control of iron regulatory proteins (IRP) 1 and 2.	Iron	105-109	5'-aminolevulinate synthase 1	Homo sapiens	51-55
12139757-6	2002	Thereby, EPO weakened the binding affinity of IRP-2 to the iron responsive element (IRE) within e-ALAS mRNA which resulted in the increased expression of e-ALAS IRE-controlled reporter gene constructs, following EPO stimulation.	Iron	59-63	erythropoietin	Homo sapiens	9-12
12139757-6	2002	Thereby, EPO weakened the binding affinity of IRP-2 to the iron responsive element (IRE) within e-ALAS mRNA which resulted in the increased expression of e-ALAS IRE-controlled reporter gene constructs, following EPO stimulation.	Iron	59-63	iron responsive element binding protein 2	Homo sapiens	46-51
12139757-6	2002	Thereby, EPO weakened the binding affinity of IRP-2 to the iron responsive element (IRE) within e-ALAS mRNA which resulted in the increased expression of e-ALAS IRE-controlled reporter gene constructs, following EPO stimulation.	Iron	59-63	5'-aminolevulinate synthase 1	Homo sapiens	98-102
12139757-6	2002	Thereby, EPO weakened the binding affinity of IRP-2 to the iron responsive element (IRE) within e-ALAS mRNA which resulted in the increased expression of e-ALAS IRE-controlled reporter gene constructs, following EPO stimulation.	Iron	59-63	5'-aminolevulinate synthase 1	Homo sapiens	156-160
12139757-6	2002	Thereby, EPO weakened the binding affinity of IRP-2 to the iron responsive element (IRE) within e-ALAS mRNA which resulted in the increased expression of e-ALAS IRE-controlled reporter gene constructs, following EPO stimulation.	Iron	59-63	erythropoietin	Homo sapiens	212-215
12139757-8	2002	These data provide new insights into the complex biochemical interaction between iron metabolism, haem biosynthesis and EPO biology.	Iron	81-85	erythropoietin	Homo sapiens	120-123
12145144-7	2002	Iron depletion has been demonstrated to be beneficial in coronary artery responses, endothelial dysfunction, insulin secretion, insulin action, and metabolic control in type 2 diabetes.	Iron	0-4	insulin	Homo sapiens	109-116
12392310-2	2002	The molecular variation of haptoglobin is one of the genetic factors influencing iron status in Caucasians.	Iron	81-85	haptoglobin	Homo sapiens	27-38
12392310-4	2002	We wanted to investigate the effect of haptoglobin polymorphism on iron status in blacks.	Iron	67-71	haptoglobin	Homo sapiens	39-50
12392310-7	2002	We compared iron status indices according to haptoglobin type.	Iron	12-16	haptoglobin	Homo sapiens	45-56
12088678-5	2002	IFN-gamma-mediated effector mechanisms may involve effects on the metabolism of tryptophan or iron, on the inducible NO synthase (iNOS), on the secretion of chemokines and adhesion molecules or on the regulation of T-cell activities.	Iron	94-98	interferon gamma	Homo sapiens	0-9
12145144-8	2002	Here, we show that iron modulates insulin action in healthy individuals and in patients with type 2 diabetes.	Iron	19-23	insulin	Homo sapiens	34-41
12224370-4	2002	Serum ferritin and transferrin saturation (TSAT) are iron indices recommended by the K/DOQI guidelines for assessing iron deficiency and iron overload.	Iron	53-57	transferrin	Homo sapiens	19-30
12359174-10	2002	Furthermore, intermittent hypoxia attenuated iron-induced reductions in GSH content, GSH/GSSG ratio, and SOD, iron-induced increase in catalase but had no effect on glutathione peroxidase.	Iron	110-114	catalase	Rattus norvegicus	135-143
12172876-6	2002	It seems justified to presume that higher daily doses of haem iron, selenium and alpha-tocopherol provided by the L-CHO diet contributed to the enhancement of catalase activity, the rise in plasma concentrations of alpha-tocopherol and selenium, which resulted in better protection of the cell membranes against damage from peroxides, as reflected by a limited release of creatine kinase into plasma.	Iron	62-66	catalase	Homo sapiens	159-167
12126757-4	2002	The induction of HIF-1 activates the expression of several genes associated with hypoxia and iron homeostasis.	Iron	93-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-22
12126757-6	2002	Therefore, it is difficult to use a conventional HIF-1 activating iron chelator (such as DFO) for mechanistic studies of protection against iron-mediated oxidative stress since any protection observed could be a consequence of either the chelation of LMrFe or the induction of protective genes associated with the hypoxic response.	Iron	66-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
12436092-2	2002	The authors describe the construction, modeling, and testing of an iron-core TMS coil that reduces power requirements and heat generation substantially, while improving the penetration of the magnetic field.	Iron	67-71	PYD and CARD domain containing	Homo sapiens	77-80
12137512-4	2002	In this report we characterize iron-binding sites on IscU that appear to nucleate [2Fe-2S] cluster assembly.	Iron	31-35	iron-sulfur cluster assembly enzyme	Homo sapiens	53-57
12172022-1	2002	We present the cloning and characterization of an Arabidopsis gene, FRD3, involved in iron homeostasis.	Iron	86-90	MATE efflux family protein	Arabidopsis thaliana	68-72
12172022-7	2002	The phenotypes of frd3 mutant plants, which are consistent with a defect in either iron deficiency signaling or iron distribution, indicate that FRD3 is an important component of iron homeostasis in Arabidopsis.	Iron	83-87	MATE efflux family protein	Arabidopsis thaliana	18-22
12172022-7	2002	The phenotypes of frd3 mutant plants, which are consistent with a defect in either iron deficiency signaling or iron distribution, indicate that FRD3 is an important component of iron homeostasis in Arabidopsis.	Iron	83-87	MATE efflux family protein	Arabidopsis thaliana	145-149
12172022-7	2002	The phenotypes of frd3 mutant plants, which are consistent with a defect in either iron deficiency signaling or iron distribution, indicate that FRD3 is an important component of iron homeostasis in Arabidopsis.	Iron	112-116	MATE efflux family protein	Arabidopsis thaliana	18-22
12172022-7	2002	The phenotypes of frd3 mutant plants, which are consistent with a defect in either iron deficiency signaling or iron distribution, indicate that FRD3 is an important component of iron homeostasis in Arabidopsis.	Iron	112-116	MATE efflux family protein	Arabidopsis thaliana	145-149
12151626-10	2002	These data suggest that the regulation of iron binding proteins by PPARalpha ligands plays a role in PP-mediated liver growth, but not in peroxisome proliferation.	Iron	42-46	peroxisome proliferator activated receptor alpha	Mus musculus	67-76
12137512-0	2002	Iron-sulfur cluster biosynthesis: characterization of iron nucleation sites for assembly of the [2Fe-2S]2+ cluster core in IscU proteins.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	123-127
12137512-0	2002	Iron-sulfur cluster biosynthesis: characterization of iron nucleation sites for assembly of the [2Fe-2S]2+ cluster core in IscU proteins.	Iron	54-58	iron-sulfur cluster assembly enzyme	Homo sapiens	123-127
12137512-5	2002	This iron-bound form of IscU is shown to be viable for subsequent IscS-mediated assembly of holo-IscU.	Iron	5-9	iron-sulfur cluster assembly enzyme	Homo sapiens	24-28
12137512-2	2002	The intermediate [2Fe-2S] IscU-bound cluster is formed by delivery of iron and sulfur to the apo-IscU, with the latter delivered through an IscS-mediated reaction.	Iron	70-74	iron-sulfur cluster assembly enzyme	Homo sapiens	26-30
12137512-2	2002	The intermediate [2Fe-2S] IscU-bound cluster is formed by delivery of iron and sulfur to the apo-IscU, with the latter delivered through an IscS-mediated reaction.	Iron	70-74	iron-sulfur cluster assembly enzyme	Homo sapiens	97-101
12137512-5	2002	This iron-bound form of IscU is shown to be viable for subsequent IscS-mediated assembly of holo-IscU.	Iron	5-9	iron-sulfur cluster assembly enzyme	Homo sapiens	97-101
12137512-7	2002	The latter observation reflects the low binding affinity of persulfido IscU for iron ion.	Iron	80-84	iron-sulfur cluster assembly enzyme	Homo sapiens	71-75
12141502-1	2002	Zerovalent iron filings have been proposed as a filter medium for removing As(III) and As(V) compounds from potable water.	Iron	11-15	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	87-92
12091367-1	2002	We describe a family with autosomal dominant inheritance of increased body iron stores characterized by raised serum ferritin concentration and normal transferrin saturation.	Iron	75-79	transferrin	Homo sapiens	151-162
12121757-3	2002	Current views on cellular iron homeostasis involving the iron regulatory proteins IRP1 and IRP2 and their interactions with the iron regulatory elements, affecting either mRNA translation (ferritin and erythroid cell delta-aminolaevulinate synthase) or mRNA stability (transferrin receptor) are discussed.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	91-95
12121757-7	2002	In reticuloendothelial cells, such as macrophages, relatively small increases in cellular iron (2-3-fold) can affect cellular signalling, as measured by NO production and activation of the nuclear transcription factor NF kappa B, as well as cellular function, as measured by the capacity of the cells to produce reactive oxygen species when stimulated.	Iron	90-94	nuclear factor kappa B subunit 1	Homo sapiens	218-228
12121757-10	2002	With the latter compound, iron also increases, which may reflect an effect of aluminium on the IRP2 protein.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	95-99
12141502-3	2002	There is conflicting evidence in the literature on whether As(V) can be reduced to As(III) by iron filter media.	Iron	94-98	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	59-64
12141502-8	2002	For freely corroding iron, the presence of As(III) and As(V) decreased the iron corrosion rate by a factor of 5 as compared to that in a 3 mM CaSO4 blank electrolyte solution.	Iron	21-25	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	55-60
12141502-8	2002	For freely corroding iron, the presence of As(III) and As(V) decreased the iron corrosion rate by a factor of 5 as compared to that in a 3 mM CaSO4 blank electrolyte solution.	Iron	75-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	55-60
12141502-10	2002	The chronoamperometry and chronopotentiometry experiments showed that elevated pH and increased As(III) to As(V) ratios near the iron surface decreased the thermodynamic favorability for As(V) reduction.	Iron	129-133	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	107-112
12141502-10	2002	The chronoamperometry and chronopotentiometry experiments showed that elevated pH and increased As(III) to As(V) ratios near the iron surface decreased the thermodynamic favorability for As(V) reduction.	Iron	129-133	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	187-192
12141472-1	2002	Iron deficiency is the most common cause of a poor response to recombinant human erythropoietin (rHuEPO) in patients receiving long-term dialysis, who are known to absorb oral iron preparations poorly.	Iron	176-180	erythropoietin	Homo sapiens	81-95
12006577-0	2002	Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain.	Iron	83-87	Fe(2+) transporter	Saccharomyces cerevisiae S288C	44-48
12130989-10	2002	The iron saturation of transferrin was significantly increased in acute disease (36.9% +/- 2.5%) compared with convalescence (18.8% +/- 1.5%; p =.0003).	Iron	4-8	transferrin	Homo sapiens	23-34
12071846-2	2002	Interferon gamma/lipopolysaccharide (IFNgamma/LPS)-activated bone marrow-derived macrophages from iNOS-deficient mice, following phagocytosis of 59Fe-labelled transferrin-anti-transferrin immune complexes, showed reduced iron release compared with cells from wild-type iNOS littermates.	Iron	221-225	interferon gamma	Mus musculus	0-16
12071846-2	2002	Interferon gamma/lipopolysaccharide (IFNgamma/LPS)-activated bone marrow-derived macrophages from iNOS-deficient mice, following phagocytosis of 59Fe-labelled transferrin-anti-transferrin immune complexes, showed reduced iron release compared with cells from wild-type iNOS littermates.	Iron	221-225	interferon gamma	Mus musculus	37-45
12086689-3	2002	The synergistic toxicity of iron and arachidonic acid has been associated with oxidative stress and lipid peroxidation in HepG2 cells that overexpress CYP2E1.	Iron	28-32	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	151-157
12085354-0	2002	Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion.	Iron	59-63	transferrin	Rattus norvegicus	41-52
12077102-7	2002	RESULTS: We found that 78% of men (mean age 42 years) and 36% of women (mean age 39 years) who were identified as C282Y homozygotes following family screening had iron overload, as defined by a transferrin saturation &gt;or=52% combined with a serum ferritin &gt;or=300 microg/l for men and &gt;or=200 microg/l for women.	Iron	163-167	transferrin	Homo sapiens	194-205
12111823-3	2002	It is predominantly located in the white matter and oligodendrocytes, which also actively synthesize the major iron proteins (e.g., ferritin, transferrin).	Iron	111-115	transferrin	Rattus norvegicus	142-153
12153530-0	2002	ERK activation and nuclear translocation in amyloid-beta peptide- and iron-stressed neuronal cell cultures.	Iron	70-74	mitogen-activated protein kinase 1	Homo sapiens	0-3
12140659-1	2002	We have conducted a case-control study in order to test for an association between 8 intragenic polymorphisms of 5 iron-related genes (transferrin, transferrin receptor1, HFE, frataxin and lactoferrin) and Parkinson disease.	Iron	115-119	transferrin	Homo sapiens	135-146
12097660-9	2002	In the iron-supplemented group, blood hemoglobin, plasma ferritin and the percentage of transferrin saturation increased (P &lt; 0.01).	Iron	7-11	transferrin	Homo sapiens	88-99
12395675-10	2002	This correlation of TIBC and transferrin saturation with lipid profile supports the hypothesis that there is a potential association between body iron status and coronary heart disease.	Iron	146-150	transferrin	Homo sapiens	29-40
12085354-4	2002	We also analyzed transferrin-bound iron uptake into surviving liver slices.	Iron	35-39	transferrin	Rattus norvegicus	17-28
12119478-11	2002	Many patients with CRF and heterozygous beta-TA who were taking EPO presented iron overload, while very few of them presented iron deficiency.	Iron	78-82	erythropoietin	Homo sapiens	64-67
12085354-9	2002	The increased expression of TfR at the cell surface resulted in increased uptake of transferrin-bound-iron into surviving liver slices; however, iron was not incorporated into ferritin.	Iron	102-106	transferrin	Rattus norvegicus	84-95
12028050-3	2002	With iron depletion, p21 induction and differentiation are blocked.	Iron	5-9	cyclin dependent kinase inhibitor 1A	Homo sapiens	21-24
12084923-1	2002	Replacement of iron with cobalt(III) selectively introduces a deep trap in the folding-energy landscape of the heme protein cytochrome c.	Iron	15-19	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	32-35
12084923-1	2002	Replacement of iron with cobalt(III) selectively introduces a deep trap in the folding-energy landscape of the heme protein cytochrome c.	Iron	15-19	cytochrome c, somatic	Homo sapiens	124-136
11972452-0	2002	Expression and purification of functional recombinant meningococcal transferrin-binding protein A. Pathogenic bacteria of the genus Neisseria have a siderophore-independent iron-uptake system reliant on a direct interaction between the bacterial cell and human transferrin (hTf), a serum protein.	Iron	173-177	transferrin	Homo sapiens	68-79
12115498-6	2002	VEGF upregulation by PA involved iron chelation because iron sulfate prevented this effect whereas the iron-chelating agent DFX induced VEGF production.	Iron	33-37	vascular endothelial growth factor A	Homo sapiens	0-4
12115498-6	2002	VEGF upregulation by PA involved iron chelation because iron sulfate prevented this effect whereas the iron-chelating agent DFX induced VEGF production.	Iron	56-60	vascular endothelial growth factor A	Homo sapiens	0-4
11920666-7	2002	The most toxic metals (V, Mn, Fe, and Ni) were also the only metals found to induce IL-6 secretion on a per cell basis (of the cytokines tested, interleukin 6 (IL-6), interleukin beta 1 (IL-1beta), transforming growth factor beta 1 (TGF-beta1), and tumor necrosis factor alpha (TNF-alpha), only IL-6 was detectable in the culture medium after 48 h for any metal at any concentration).	Iron	30-32	interleukin 6	Homo sapiens	84-88
12401306-6	2002	This is followed by intracellular transfer of iron to the basolateral enterocyte membrane with subsequent transfer and release of iron to transferrin in the portal blood.	Iron	46-50	transferrin	Homo sapiens	138-149
12401306-6	2002	This is followed by intracellular transfer of iron to the basolateral enterocyte membrane with subsequent transfer and release of iron to transferrin in the portal blood.	Iron	130-134	transferrin	Homo sapiens	138-149
12401310-5	2002	Two screening tests are available: measurement of the serum iron transferrin saturation (Tf%) and genetic testing for HFE mutations.	Iron	60-64	transferrin	Homo sapiens	65-76
12057761-3	2002	A major mechanism for the regulation of iron homeostasis relies on the post-transcriptional control of ferritin and transferrin receptor mRNAs, which are recognized by two cytoplasmic iron regulatory proteins (IRP-1 and IRP-2) that modulate their translation and stability, respectively.	Iron	40-44	transferrin	Homo sapiens	116-127
12057761-3	2002	A major mechanism for the regulation of iron homeostasis relies on the post-transcriptional control of ferritin and transferrin receptor mRNAs, which are recognized by two cytoplasmic iron regulatory proteins (IRP-1 and IRP-2) that modulate their translation and stability, respectively.	Iron	40-44	iron responsive element binding protein 2	Homo sapiens	220-225
12044175-3	2002	To investigate the role of the synergistic anion in the iron-binding and iron-donating properties of human transferrin, a bilobal protein with an iron binding site in each lobe, we have selectively mutated the anion-binding threonine and arginine ligands that form an essential part of the electrostatic and hydrogen-bonding network holding the synergistic anion to the protein.	Iron	56-60	transferrin	Homo sapiens	107-118
12708088-6	2002	ACD may be seen as an immune driven disease since cytokines and their products cause (i) a diversion of iron traffic into the reticuloendothelial systems, thus limiting the availability of the metal to erythroid progenitor cells for haem biosynthesis, (ii) an inhibition of erythroid progenitor cell proliferation and (iii) blunted production and activity of erythropoietin (EPO).	Iron	104-108	erythropoietin	Homo sapiens	359-373
12708088-6	2002	ACD may be seen as an immune driven disease since cytokines and their products cause (i) a diversion of iron traffic into the reticuloendothelial systems, thus limiting the availability of the metal to erythroid progenitor cells for haem biosynthesis, (ii) an inhibition of erythroid progenitor cell proliferation and (iii) blunted production and activity of erythropoietin (EPO).	Iron	104-108	erythropoietin	Homo sapiens	375-378
12708088-8	2002	The latter can be referred to the correction of an inhibitory effect of iron towards IFN-gamma induced immune effector pathways in macrophages.	Iron	72-76	interferon gamma	Homo sapiens	85-94
12038884-0	2002	Comparison of 2 iron doses in infants receiving recombinant human erythropoietin therapy.	Iron	16-20	erythropoietin	Homo sapiens	66-80
12127952-4	2002	Diagnosis of ACD can be assessed by examination of chances in serum iron parameters with low to normal serum iron, transferrin saturation and transferrin concentrations on the one hand and normal to increased ferritin, zinc protoporphyrin IX and cytokine levels on the other side.	Iron	68-72	transferrin	Homo sapiens	115-126
12127952-4	2002	Diagnosis of ACD can be assessed by examination of chances in serum iron parameters with low to normal serum iron, transferrin saturation and transferrin concentrations on the one hand and normal to increased ferritin, zinc protoporphyrin IX and cytokine levels on the other side.	Iron	68-72	transferrin	Homo sapiens	142-153
12028050-10	2002	Iron deprivation blocked induction of p21 (WAF1/CIP1) expression in both DC and macrophage cultures.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	38-41
12028050-10	2002	Iron deprivation blocked induction of p21 (WAF1/CIP1) expression in both DC and macrophage cultures.	Iron	0-4	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-52
12028050-12	2002	These data indicate that a key role of iron in haematopoiesis is to support induction of p21 which, in turn, is required for DC and macrophage differentiation.	Iron	39-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-92
12078949-3	2002	PATIENTS AND METHODS: We retrospectively evaluated parameters of iron metabolism over a 4-year period among all our chronic hemodialysis patients who had been receiving intravenous iron and erythropoietin.	Iron	65-69	erythropoietin	Homo sapiens	190-204
12078950-7	2002	iron, there was an increased risk of bacteremia associated with concurrent administration of erythropoietin, which was not observed in patients receiving iron orally.	Iron	0-4	erythropoietin	Homo sapiens	93-107
12047627-7	2002	However, NO is required for iron-induced ferritin accumulation, as the NO scavenger CPTIO prevents ferritin transcript accumulation in Arabidopsis suspension cultures treated with iron.	Iron	28-32	ferritin-1, chloroplastic	Nicotiana tabacum	41-49
12243984-6	2002	The study of X-linked sideroblastic anaemia has shown that the entry of iron into the mitochondria is poorly controlled and able to occur when protoporphyrin production is reduced, as is seen with the ALA-S2 mutations, or when it is increased as has been seen with ABC7 transporter mutations.	Iron	72-76	5'-aminolevulinate synthase 1	Homo sapiens	201-206
12243984-8	2002	Erythroblasts in ACD seem doubly equipped to protect their iron supply with their ability to increase the efficiency of transferrin-iron uptake as well as to activate the IRP/IRE system to increase surface TfR production.	Iron	132-136	transferrin	Homo sapiens	120-131
12084824-5	2002	FRO1 was isolated through positional cloning and found to encode a protein with high similarity to the 18-kD Fe-S subunit of complex I (NADH dehydrogenase, EC 1.6.5.3) in the mitochondrial electron transfer chain.	Iron	109-113	NADH-ubiquinone oxidoreductase-like protein	Arabidopsis thaliana	0-4
12015365-1	2002	Hypoxia-inducible factor (HIF)-1 is stabilized by hypoxia and iron chelation.	Iron	62-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
12047627-0	2002	Nitric oxide mediates iron-induced ferritin accumulation in Arabidopsis.	Iron	22-26	ferritin-1, chloroplastic	Nicotiana tabacum	35-43
12047627-4	2002	This suggests that NO may elevate free iron levels in the cells by converting tobacco cytoplasmic aconitase into a mRNA binding protein that negatively regulates accumulation of ferritin.	Iron	39-43	ferritin-1, chloroplastic	Nicotiana tabacum	178-186
12047627-7	2002	However, NO is required for iron-induced ferritin accumulation, as the NO scavenger CPTIO prevents ferritin transcript accumulation in Arabidopsis suspension cultures treated with iron.	Iron	28-32	ferritin-1, chloroplastic	Nicotiana tabacum	99-107
12047627-7	2002	However, NO is required for iron-induced ferritin accumulation, as the NO scavenger CPTIO prevents ferritin transcript accumulation in Arabidopsis suspension cultures treated with iron.	Iron	180-184	ferritin-1, chloroplastic	Nicotiana tabacum	99-107
12047627-8	2002	The pathway is ser/thr phosphatase-dependent and necessitates protein synthesis; furthermore, NO mediates ferritin regulation through the IDRS sequence of the Atfer1 promoter responsible for transcriptional repression under low iron supply.	Iron	228-232	ferritin-1, chloroplastic	Nicotiana tabacum	106-114
12047627-9	2002	NO, by acting downstream of iron in the induction of ferritin transcript accumulation is therefore a key signaling molecule for regulation of iron homeostasis in plants.	Iron	28-32	ferritin-1, chloroplastic	Nicotiana tabacum	53-61
12047627-9	2002	NO, by acting downstream of iron in the induction of ferritin transcript accumulation is therefore a key signaling molecule for regulation of iron homeostasis in plants.	Iron	142-146	ferritin-1, chloroplastic	Nicotiana tabacum	53-61
11856741-0	2002	Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis.	Iron	31-35	serotransferrin	Bos taurus	0-11
12069185-8	2002	Iron supplementation of macrophage cultures significantly increased interleukin-1beta-induced TNF release.	Iron	0-4	interleukin 1 beta	Homo sapiens	68-85
12069185-8	2002	Iron supplementation of macrophage cultures significantly increased interleukin-1beta-induced TNF release.	Iron	0-4	tumor necrosis factor	Homo sapiens	94-97
11996572-1	2002	Axial iron ligation and protein encapsulation of the heme cofactor have been investigated as effectors of the reduction potential (E degrees ") of cytochrome c through direct electrochemistry experiments.	Iron	6-10	cytochrome c, somatic	Homo sapiens	147-159
11996572-4	2002	These ligands replace Met80 and a water molecule axially coordinated to the heme iron in cytochrome c and MP11, respectively.	Iron	81-85	cytochrome c, somatic	Homo sapiens	89-101
12126254-5	2002	The aim of this study was to investigate the effects of TNF-alpha on normal and iron-loaded rat hepatocytes exposed to oxidative stress.	Iron	80-84	tumor necrosis factor	Rattus norvegicus	56-65
11856741-0	2002	Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis.	Iron	139-143	serotransferrin	Bos taurus	0-11
11856741-4	2002	Furthermore, DOX-induced iron uptake was shown to be mediated by the transferrin receptor (TfR)-dependent mechanism.	Iron	25-29	transferrin receptor	Bos taurus	69-89
11856741-4	2002	Furthermore, DOX-induced iron uptake was shown to be mediated by the transferrin receptor (TfR)-dependent mechanism.	Iron	25-29	transferrin receptor	Bos taurus	91-94
11856741-5	2002	Treatment with the anti-TfR antibody (IgA class) dramatically inhibited DOX-induced apoptosis, iron uptake, and intracellular oxidant formation as measured by fluorescence using dichlorodihydrofluorescein.	Iron	95-99	transferrin receptor	Bos taurus	24-27
11980473-0	2002	Resonance Raman detection of the Fe-S bond in endothelial nitric oxide synthase.	Iron	33-37	nitric oxide synthase 3	Homo sapiens	46-79
11856741-7	2002	Based on these findings, we conclude that DOX-induced iron signaling is regulated by the cell surface TfR expression, intracellular oxidant levels, and iron regulatory proteins.	Iron	54-58	transferrin receptor	Bos taurus	102-105
11856741-8	2002	The implications of TfR-dependent iron transport in oxidant-induced apoptosis in endothelial cells are discussed.	Iron	34-38	transferrin receptor	Bos taurus	20-23
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	179-183	transferrin	Homo sapiens	245-256
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	279-283	transferrin	Homo sapiens	245-256
11943663-2	2002	We tested the hypothesis that non-transferrin-bound iron uptake by airway epithelial cells is associated with Nramp2/DMT1/DCT1 and that exposure to iron can increase Nramp2/DMT1/DCT1 mRNA and protein expression and transport of this metal.	Iron	52-56	transferrin	Homo sapiens	34-45
12113300-2	2002	Soluble transferrin receptor (sTfR) is reported to be a reliable marker for the diagnosis of iron deficiency, especially when iron metabolism is influenced by inflammatory disorders such as infection, chronic inflammation and cancer-related anemia.	Iron	93-97	transferrin	Homo sapiens	8-19
12012183-4	2002	The developed methodology was applied to the colorimetric determination of total Fe and Cr (VI) in wastewaters at 0.1-6.0 mg L-1 and 0.03-1.0 mg L-1, respectively.	Iron	81-83	immunoglobulin kappa variable 1-16	Homo sapiens	125-134
12012183-4	2002	The developed methodology was applied to the colorimetric determination of total Fe and Cr (VI) in wastewaters at 0.1-6.0 mg L-1 and 0.03-1.0 mg L-1, respectively.	Iron	81-83	immunoglobulin kappa variable 1-16	Homo sapiens	125-128
12038596-1	2002	Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release.	Iron	19-23	transferrin	Homo sapiens	36-47
12038596-1	2002	Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release.	Iron	19-23	transferrin	Homo sapiens	62-73
12038596-1	2002	Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release.	Iron	19-23	transferrin	Homo sapiens	62-73
12038596-1	2002	Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release.	Iron	148-152	transferrin	Homo sapiens	36-47
12038596-1	2002	Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release.	Iron	148-152	transferrin	Homo sapiens	62-73
12038596-1	2002	Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release.	Iron	148-152	transferrin	Homo sapiens	62-73
12035860-9	2002	Other vitamins such as folate, B12, and vitamin A may enhance the effect of iron supplementation in populations where multiple nutrition deficiencies exist.	Iron	76-80	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	31-34
12020627-2	2002	Transferrin has also been proposed as a mediator of tubular toxicity because the reabsorption of transferrin results in the release of reactive iron in proximal tubular cells, promoting the formation of hydroxyl radicals.	Iron	144-148	transferrin	Homo sapiens	0-11
12020627-2	2002	Transferrin has also been proposed as a mediator of tubular toxicity because the reabsorption of transferrin results in the release of reactive iron in proximal tubular cells, promoting the formation of hydroxyl radicals.	Iron	144-148	transferrin	Homo sapiens	97-108
11991850-4	2002	This article outlines the current state of knowledge on cellular iron homeostasis, with particular reference to the iron regulatory proteins (IRP1, IRP2 and HFE) and the iron membrane transport proteins, two of which have been shown to be members of the natural resistance- associated macrophage protein family (Nramp1 and 2).	Iron	65-69	iron responsive element binding protein 2	Homo sapiens	148-152
11991850-4	2002	This article outlines the current state of knowledge on cellular iron homeostasis, with particular reference to the iron regulatory proteins (IRP1, IRP2 and HFE) and the iron membrane transport proteins, two of which have been shown to be members of the natural resistance- associated macrophage protein family (Nramp1 and 2).	Iron	65-69	solute carrier family 11 member 1	Homo sapiens	312-324
11961017-9	2002	Conversely, intravenous EPO and iron were associated with higher prescribed EPO doses (all P = 0.0001).	Iron	32-36	erythropoietin	Homo sapiens	76-79
11933019-3	2002	A major pathway for cellular iron uptake is through internalization of the complex of iron-bound transferrin and the transferrin receptor, which is negatively modulated by HFE, a protein related to hereditary hemochromatosis.	Iron	29-33	transferrin	Homo sapiens	97-108
11933019-3	2002	A major pathway for cellular iron uptake is through internalization of the complex of iron-bound transferrin and the transferrin receptor, which is negatively modulated by HFE, a protein related to hereditary hemochromatosis.	Iron	29-33	transferrin	Homo sapiens	117-128
11933019-3	2002	A major pathway for cellular iron uptake is through internalization of the complex of iron-bound transferrin and the transferrin receptor, which is negatively modulated by HFE, a protein related to hereditary hemochromatosis.	Iron	86-90	transferrin	Homo sapiens	97-108
11933019-3	2002	A major pathway for cellular iron uptake is through internalization of the complex of iron-bound transferrin and the transferrin receptor, which is negatively modulated by HFE, a protein related to hereditary hemochromatosis.	Iron	86-90	transferrin	Homo sapiens	117-128
11933019-4	2002	Iron is released from transferrin as the result of the acidic pH in endosome and then is transported to the cytosol by DMT1.	Iron	0-4	transferrin	Homo sapiens	22-33
11933019-6	2002	Apart from iron, many other metal ions of therapeutic and diagnostic interests can also bind to transferrin at the iron sites and their transferrin complexes can be recognized by many cells.	Iron	11-15	transferrin	Homo sapiens	96-107
11933019-6	2002	Apart from iron, many other metal ions of therapeutic and diagnostic interests can also bind to transferrin at the iron sites and their transferrin complexes can be recognized by many cells.	Iron	11-15	transferrin	Homo sapiens	136-147
11933019-6	2002	Apart from iron, many other metal ions of therapeutic and diagnostic interests can also bind to transferrin at the iron sites and their transferrin complexes can be recognized by many cells.	Iron	115-119	transferrin	Homo sapiens	96-107
11933019-6	2002	Apart from iron, many other metal ions of therapeutic and diagnostic interests can also bind to transferrin at the iron sites and their transferrin complexes can be recognized by many cells.	Iron	115-119	transferrin	Homo sapiens	136-147
11933021-2	2002	Nonsteroidal aromatase inhibitors (NSAIs) are competitive inhibitors of aromatase, which bind to the enzyme active site by coordinating the iron atom present in the heme group of the P450 protein.	Iron	140-144	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	13-22
11933021-2	2002	Nonsteroidal aromatase inhibitors (NSAIs) are competitive inhibitors of aromatase, which bind to the enzyme active site by coordinating the iron atom present in the heme group of the P450 protein.	Iron	140-144	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	72-81
12150251-2	2002	Zero-valent iron reduction of nitroaromatics coupled with peroxidase-catalyzed capture of the resulting anilines as a two-step strategy for removing nitroaromatics from wastewater and process water is investigated here.	Iron	12-16	peroxidase	Glycine max	58-68
12150251-5	2002	The enzymatic treatment following zero-valent iron reduction was carried out in a plug-flow reactor using a crude preparation of the enzyme soybean peroxidase extracted from soybean hulls.	Iron	46-50	peroxidase	Glycine max	148-158
12051835-0	2002	Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron.	Iron	58-62	Fet4p	Saccharomyces cerevisiae S288C	39-43
11993874-4	2002	Interaction of As(III) and As(V) with the sulfide surfaces shows primary coordination to four oxygens (As-O: 1.69-1.76 A) with further sulfur (approximately 3.1 A) and iron (3.4-3.5 A) shells suggesting outer sphere complexation.	Iron	168-172	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-32
12007804-5	2002	One cytochrome c was specific for sulfur conditions while three were specific for iron conditions, suggesting that cytochrome c synthesis is modulated depending on the electron donor.	Iron	82-86	cytochrome c, somatic	Homo sapiens	4-16
12007804-5	2002	One cytochrome c was specific for sulfur conditions while three were specific for iron conditions, suggesting that cytochrome c synthesis is modulated depending on the electron donor.	Iron	82-86	cytochrome c, somatic	Homo sapiens	115-127
11939777-5	2002	The two heme groups have nearly parallel heme planes and are stacked at van der Waals distances with an iron-to-iron distance of only 9.9 A, two structural features that are also present in the split-Soret diheme cytochrome c from Desulfovibrio desulfuricans ATCC 27774, which is otherwise unrelated in the peptide chain folding pattern.	Iron	104-108	cytochrome c, somatic	Homo sapiens	213-225
11939777-5	2002	The two heme groups have nearly parallel heme planes and are stacked at van der Waals distances with an iron-to-iron distance of only 9.9 A, two structural features that are also present in the split-Soret diheme cytochrome c from Desulfovibrio desulfuricans ATCC 27774, which is otherwise unrelated in the peptide chain folding pattern.	Iron	112-116	cytochrome c, somatic	Homo sapiens	213-225
12051835-7	2002	Secondly, the loss of Rox1p repression under anaerobic conditions serves to induce FET4 and facilitate continual accumulation of iron.	Iron	129-133	Rox1p	Saccharomyces cerevisiae S288C	22-27
12051835-8	2002	We noted that fet4 mutants accumulate lower levels of iron under anaerobic conditions.	Iron	54-58	Fet4p	Saccharomyces cerevisiae S288C	14-18
12051835-10	2002	We found that FET4 contains a complex promoter regulated both by oxygen and iron status.	Iron	76-80	Fet4p	Saccharomyces cerevisiae S288C	14-18
12051835-15	2002	Fet4p is not the only metal transporter that is negatively regulated by oxygen; we find that Rox1p also represses S. cerevisiae SMF3, proposed to function in vacuolar iron transport.	Iron	167-171	Fet4p	Saccharomyces cerevisiae S288C	0-5
12051835-15	2002	Fet4p is not the only metal transporter that is negatively regulated by oxygen; we find that Rox1p also represses S. cerevisiae SMF3, proposed to function in vacuolar iron transport.	Iron	167-171	Rox1p	Saccharomyces cerevisiae S288C	93-98
12051859-4	2002	pb5 functionality was attested in vivo by its ability to impair infection of E. coli cells by phage T5 and Phi80, and to prevent growth of bacteria on iron-ferrichrome as unique iron source.	Iron	151-155	receptor-binding tail protein	Escherichia phage T5	0-3
12003382-9	2002	The transferrin saturation was the only serum iron marker the value of which was significantly higher among C282Y heterozygotes with alcoholic cirrhosis compared to those without mutation.	Iron	46-50	transferrin	Homo sapiens	4-15
11916761-7	2002	RESULTS: Six weeks of iron supplementation significantly improved serum ferritin and serum transferrin receptor (sTfR) concentrations and transferrin saturation without affecting hemoglobin concentrations or hematocrit.	Iron	22-26	transferrin	Homo sapiens	91-102
11916761-7	2002	RESULTS: Six weeks of iron supplementation significantly improved serum ferritin and serum transferrin receptor (sTfR) concentrations and transferrin saturation without affecting hemoglobin concentrations or hematocrit.	Iron	22-26	transferrin	Homo sapiens	138-149
11952508-0	2002	Intravenous ascorbic acid administration for erythropoietin-hyporesponsive anemia in iron loaded hemodialysis patients.	Iron	85-89	erythropoietin	Homo sapiens	45-59
11952508-1	2002	Intravenous ascorbic acid administration (IVAA) could override recombinant human erythropoietin (rHuEPO) resistance in hemodialysis patients with iron overload.	Iron	146-150	erythropoietin	Homo sapiens	81-95
11916918-1	2002	Iron-related insulin-resistance is improved by iron depletion or treatment with iron chelators.	Iron	0-4	insulin	Homo sapiens	13-20
11903051-0	2002	Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake.	Iron	83-87	solute carrier family 11 member 1	Homo sapiens	0-19
11903051-0	2002	Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake.	Iron	83-87	solute carrier family 11 member 1	Homo sapiens	21-28
11903051-0	2002	Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake.	Iron	83-87	solute carrier family 11 member 1	Homo sapiens	39-45
11903051-2	2002	In the present study the role of Slc11a1 in iron turnover is examined in macrophages transfected with Slc11a1(Gly169) (wild-type) or Slc11a1(Asp169) (mutant=functional null) alleles.	Iron	44-48	solute carrier family 11 member 1	Homo sapiens	33-40
11903051-3	2002	Following direct acquisition of transferrin (Tf)-bound iron via the Tf receptor, iron uptake and release was equivalent in wild-type and mutant macrophages and was not influenced by interferon-gamma/lipopolysaccharide activation.	Iron	55-59	transferrin	Homo sapiens	32-43
11903051-3	2002	Following direct acquisition of transferrin (Tf)-bound iron via the Tf receptor, iron uptake and release was equivalent in wild-type and mutant macrophages and was not influenced by interferon-gamma/lipopolysaccharide activation.	Iron	55-59	transferrin	Homo sapiens	45-47
11903051-3	2002	Following direct acquisition of transferrin (Tf)-bound iron via the Tf receptor, iron uptake and release was equivalent in wild-type and mutant macrophages and was not influenced by interferon-gamma/lipopolysaccharide activation.	Iron	81-85	transferrin	Homo sapiens	32-43
11903051-3	2002	Following direct acquisition of transferrin (Tf)-bound iron via the Tf receptor, iron uptake and release was equivalent in wild-type and mutant macrophages and was not influenced by interferon-gamma/lipopolysaccharide activation.	Iron	81-85	transferrin	Homo sapiens	45-47
11903051-4	2002	Following phagocytosis of [(59)Fe]Tf-anti-Tf immune complexes, iron uptake was equivalent and up-regulated similarly with activation, but intracellular distribution was markedly different.	Iron	63-67	transferrin	Homo sapiens	34-36
11903051-4	2002	Following phagocytosis of [(59)Fe]Tf-anti-Tf immune complexes, iron uptake was equivalent and up-regulated similarly with activation, but intracellular distribution was markedly different.	Iron	63-67	transferrin	Homo sapiens	42-44
11923069-1	2002	For many years it has been known that neoplastic cells express high levels of the transferrin receptor 1 (TfR1) and internalize iron (Fe) from transferrin (Tf) at a tremendous rate.	Iron	128-132	transferrin	Homo sapiens	82-93
11923069-1	2002	For many years it has been known that neoplastic cells express high levels of the transferrin receptor 1 (TfR1) and internalize iron (Fe) from transferrin (Tf) at a tremendous rate.	Iron	134-136	transferrin	Homo sapiens	82-93
11934617-2	2002	Some bacteria also use iron in heme, hemoglobin, hemopexin, transferrin and lactoferrin of eukaryotic hosts.	Iron	23-27	transferrin	Homo sapiens	60-71
11916918-1	2002	Iron-related insulin-resistance is improved by iron depletion or treatment with iron chelators.	Iron	47-51	insulin	Homo sapiens	13-20
11916918-1	2002	Iron-related insulin-resistance is improved by iron depletion or treatment with iron chelators.	Iron	80-84	insulin	Homo sapiens	13-20
11910345-6	2002	CONCLUSIONS: These results reflect the insulin-sparing effect of iron depletion and indicate a key role of iron and hyperinsulinemia in the pathogenesis of NAFLD.	Iron	65-69	insulin	Homo sapiens	39-46
11933051-1	2002	Alterations in iron levels are likely to influence the biological actions of Mn in PC12 cells, because both metals are transported via the divalent metal transporter 1 (DMT1; also Nramp2 or DCT1).	Iron	15-19	solute carrier family 11 member 2	Rattus norvegicus	139-167
12028811-9	2002	The finding of decreased transferrin with increased ferritin suggests a local cellular response via iron-response elements (IRE) associated with the mRNAs for these two iron-binding proteins.	Iron	100-104	transferrin	Homo sapiens	25-36
12028811-9	2002	The finding of decreased transferrin with increased ferritin suggests a local cellular response via iron-response elements (IRE) associated with the mRNAs for these two iron-binding proteins.	Iron	169-173	transferrin	Homo sapiens	25-36
11975695-0	2002	Nomogram for individualizing supplementary iron doses during erythropoietin therapy in haemodialysis patients.	Iron	43-47	erythropoietin	Homo sapiens	61-75
11975695-1	2002	AIMS: An adequate iron supplement is crucial not only for prompt erythropoiesis but also for the restoration of tissue iron reserves in haemodialysis patients receiving recombinant human erythropoietin (r-HuEPO).	Iron	18-22	erythropoietin	Homo sapiens	187-201
11909691-1	2002	Iron, to be redox cycling active, has to be released from its macromolecular complexes (ferritin, transferrin, hemoproteins, etc.).	Iron	0-4	transferrin	Homo sapiens	98-109
12034031-1	2002	In patients with chronic hepatitis C, prior studies have suggested that increased hepatic iron concentration (HIC) is predictive of a poor response to interferon (IFN) monotherapy.	Iron	90-94	interferon alpha 1	Homo sapiens	163-166
11933051-1	2002	Alterations in iron levels are likely to influence the biological actions of Mn in PC12 cells, because both metals are transported via the divalent metal transporter 1 (DMT1; also Nramp2 or DCT1).	Iron	15-19	solute carrier family 11 member 2	Rattus norvegicus	169-173
11933051-1	2002	Alterations in iron levels are likely to influence the biological actions of Mn in PC12 cells, because both metals are transported via the divalent metal transporter 1 (DMT1; also Nramp2 or DCT1).	Iron	15-19	solute carrier family 11 member 2	Rattus norvegicus	180-186
11933051-8	2002	In addition, coincubation of DfO with Mn in PC12 cells resulted in increased expression of both the iron response element-positive and the iron response element-negative forms of DMT1.	Iron	139-143	solute carrier family 11 member 2	Rattus norvegicus	179-183
11933051-9	2002	Taken together, these results demonstrate that iron status is likely to have a direct effect on the uptake and biological actions of Mn and probably other divalent metals that are transported by DMT1.	Iron	47-51	solute carrier family 11 member 2	Rattus norvegicus	195-199
11978060-6	2002	Addition of unhindered iron, in the form of iron chloride, to the treated-explants reversed the stimulatory effect on EVT outgrowth and HIF-1alpha expression.	Iron	23-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
11950925-6	2002	Reduction of iron levels in grx5 null mutants does not restore the activity of iron/sulfur enzymes, and cell growth defects are not suppressed in anaerobiosis or in the presence of disulfide reductants.	Iron	13-17	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	28-32
11950925-7	2002	Hence, Grx5 forms part of the mitochondrial machinery involved in the synthesis and assembly of iron/sulfur centers.	Iron	96-100	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	7-11
11950925-0	2002	Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes.	Iron	66-70	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	0-4
11950925-3	2002	Phenotypic defects associated with the absence of Grx5 are suppressed by overexpression of SSQ1 and ISA2, two genes involved in the synthesis and assembly of iron/sulfur clusters into proteins.	Iron	158-162	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	50-54
11950925-3	2002	Phenotypic defects associated with the absence of Grx5 are suppressed by overexpression of SSQ1 and ISA2, two genes involved in the synthesis and assembly of iron/sulfur clusters into proteins.	Iron	158-162	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	91-95
11950925-3	2002	Phenotypic defects associated with the absence of Grx5 are suppressed by overexpression of SSQ1 and ISA2, two genes involved in the synthesis and assembly of iron/sulfur clusters into proteins.	Iron	158-162	Isa2p	Saccharomyces cerevisiae S288C	100-104
11950925-5	2002	Absence of Grx5 causes: 1) iron accumulation in the cell, which in turn could promote oxidative damage, and 2) inactivation of enzymes requiring iron/sulfur clusters for their activity.	Iron	27-31	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	11-15
11950925-5	2002	Absence of Grx5 causes: 1) iron accumulation in the cell, which in turn could promote oxidative damage, and 2) inactivation of enzymes requiring iron/sulfur clusters for their activity.	Iron	145-149	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	11-15
11877579-0	2002	Evaluation of intestinal iron absorption by indirect methods in patients on hemodialysis receiving oral iron and recombinant human erythropoietin.	Iron	25-29	erythropoietin	Homo sapiens	131-145
12089896-4	2002	The use of recombinant human erythropoietin accelerates erythropoesis and by so increases iron requirement frequently far higher than the ability of iron stores to "transfer" iron to the bone marrow--this may be a result of ineffective mobilisation of iron stores and/or ineffective transport.	Iron	90-94	erythropoietin	Homo sapiens	29-43
17660651-6	2002	Intravenous iron was administered to maintain the ferritin levels and transferrin saturation ratio within normal range.	Iron	12-16	transferrin	Homo sapiens	70-81
17660651-25	2002	iron supplementation in chronic HD patients receiving recombinant EPO may be beneficial in the initial phase of treatment in attaining the target Hb with lower doses of EPO, regardless of the status of the iron indices.	Iron	0-4	erythropoietin	Homo sapiens	66-69
17660651-25	2002	iron supplementation in chronic HD patients receiving recombinant EPO may be beneficial in the initial phase of treatment in attaining the target Hb with lower doses of EPO, regardless of the status of the iron indices.	Iron	0-4	erythropoietin	Homo sapiens	169-172
11867720-5	2002	However, overexpression of both HFE and beta2M had the reverse effect and resulted in an increase in TfR1-dependent iron uptake and increased iron levels in the cells.	Iron	116-120	beta-2-microglobulin	Cricetulus griseus	40-46
11867720-5	2002	However, overexpression of both HFE and beta2M had the reverse effect and resulted in an increase in TfR1-dependent iron uptake and increased iron levels in the cells.	Iron	142-146	beta-2-microglobulin	Cricetulus griseus	40-46
11867720-8	2002	We propose that Chinese hamster ovary cells provide a model to explain the effect of the HFE-beta2M complex in duodenal crypt cells, where the HFE-beta2M complex appears to facilitate the uptake of transferrin-bound iron to sense the level of body iron stores.	Iron	216-220	beta-2-microglobulin	Cricetulus griseus	93-99
11867720-8	2002	We propose that Chinese hamster ovary cells provide a model to explain the effect of the HFE-beta2M complex in duodenal crypt cells, where the HFE-beta2M complex appears to facilitate the uptake of transferrin-bound iron to sense the level of body iron stores.	Iron	216-220	beta-2-microglobulin	Cricetulus griseus	147-153
11867720-8	2002	We propose that Chinese hamster ovary cells provide a model to explain the effect of the HFE-beta2M complex in duodenal crypt cells, where the HFE-beta2M complex appears to facilitate the uptake of transferrin-bound iron to sense the level of body iron stores.	Iron	248-252	beta-2-microglobulin	Cricetulus griseus	93-99
11867720-8	2002	We propose that Chinese hamster ovary cells provide a model to explain the effect of the HFE-beta2M complex in duodenal crypt cells, where the HFE-beta2M complex appears to facilitate the uptake of transferrin-bound iron to sense the level of body iron stores.	Iron	248-252	beta-2-microglobulin	Cricetulus griseus	147-153
11841990-5	2002	The HFE protein is homologous to major histocompatibility complex class I proteins but is not an iron carrier, whereas biochemical and cell biological studies have shown that the transferrin receptor, the main protein devoted to cellular uptake of transferrin iron, interacts with HFE.	Iron	260-264	transferrin	Homo sapiens	179-190
11841990-5	2002	The HFE protein is homologous to major histocompatibility complex class I proteins but is not an iron carrier, whereas biochemical and cell biological studies have shown that the transferrin receptor, the main protein devoted to cellular uptake of transferrin iron, interacts with HFE.	Iron	260-264	transferrin	Homo sapiens	248-259
11952985-0	2002	Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units.	Iron	32-36	transferrin	Homo sapiens	14-25
11952985-1	2002	BACKGROUND AND OBJECTIVES: Non-transferrin bound iron (NTBI) is associated with increased morbidity in a number of transfusion-dependent disease states such as the severe haemoglobinopathies.	Iron	49-53	transferrin	Homo sapiens	31-42
11886430-1	2002	BACKGROUND: Many haemodialysis patients treated with recombinant human erythropoietin (r-HuEPO) receive intravenous iron supplementation on a regular basis.	Iron	116-120	erythropoietin	Homo sapiens	71-85
11850263-5	2002	Among the genes that were differentially expressed with chloroquine treatment were a number of metal transporters involved in iron acquisition (SIT1, ARN2, ARN4, and SMF2).	Iron	126-130	siderophore transporter	Saccharomyces cerevisiae S288C	144-148
11850263-5	2002	Among the genes that were differentially expressed with chloroquine treatment were a number of metal transporters involved in iron acquisition (SIT1, ARN2, ARN4, and SMF2).	Iron	126-130	divalent metal ion transporter SMF2	Saccharomyces cerevisiae S288C	166-170
12005209-2	2002	Among them, the genetic polymorphism of the hemoglobin (Hb)-binding plasma protein haptoglobin (Hp) has been shown to affect iron turnover.	Iron	125-129	haptoglobin	Homo sapiens	83-94
11850263-8	2002	For these experiments, we utilized yeast lacking the major iron uptake pathways (FET3 and FET4) and yeast deficient in SIT1, encoding the major up-regulated iron siderophore transporter.	Iron	157-161	siderophore transporter	Saccharomyces cerevisiae S288C	119-123
11920884-2	2002	Iron-free human serum transferrin is a suitable chiral selector in capillary electrophoresis used in native form in solution.	Iron	0-4	transferrin	Homo sapiens	22-33
11920884-6	2002	Molecular modelling was performed to characterize the binding areas at the iron binding site of iron-free transferrin.	Iron	75-79	transferrin	Homo sapiens	106-117
11920884-6	2002	Molecular modelling was performed to characterize the binding areas at the iron binding site of iron-free transferrin.	Iron	96-100	transferrin	Homo sapiens	106-117
11886434-0	2002	Transferrin toxin but not transferrin receptor immunotoxin is influenced by free transferrin and iron saturation.	Iron	97-101	transferrin	Homo sapiens	0-11
11886434-10	2002	CONCLUSION: Transferrin-based toxin conjugates are strongly influenced by the presence of free transferrin and the iron saturation state.	Iron	115-119	transferrin	Homo sapiens	12-23
11886435-3	2002	As shown by several groups, iron also modulates immune effector mechanisms, such as cytokine activities (IFN-gamma effector pathways towards macrophages), nitric oxide (NO) formation or immune cell proliferation, and thus host immune surveillance.	Iron	28-32	interferon gamma	Homo sapiens	105-114
11948235-3	2002	PAHX, an iron(II) and 2-oxoglutarate-dependent oxygenase is located on chromosome 10p13.	Iron	9-13	phytanoyl-CoA hydroxylase	Mus musculus	0-4
11875007-5	2002	In DBA/2 Hfe-/- mice, increased intestinal iron absorption results from the concomitant up-regulation of the Dcytb, DMT1, and FPN1 messengers.	Iron	43-47	cytochrome b reductase 1	Mus musculus	109-114
11875007-5	2002	In DBA/2 Hfe-/- mice, increased intestinal iron absorption results from the concomitant up-regulation of the Dcytb, DMT1, and FPN1 messengers.	Iron	43-47	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	126-130
11974664-7	2002	A significant inverse correlation coefficient between a CRP level &gt; 1 mg/dl and hemoglobin, transferrin levels and percent transferrin saturation was observed: the strongest correlation was with serum iron levels.	Iron	204-208	C-reactive protein	Homo sapiens	56-59
11974664-7	2002	A significant inverse correlation coefficient between a CRP level &gt; 1 mg/dl and hemoglobin, transferrin levels and percent transferrin saturation was observed: the strongest correlation was with serum iron levels.	Iron	204-208	transferrin	Homo sapiens	126-137
12071600-0	2002	Low-dose intravenous iron administration in chronic hemodialysis patients treated with recombinant human erythropoietin.	Iron	21-25	erythropoietin	Homo sapiens	105-119
11909746-1	2002	Slc11a1 (solute carrier family 11 member 1) (formerly Nramp1) modulation of iron metabolism in macrophages plays an important role in early phase macrophage activation, and therefore host innate immunity.	Iron	76-80	solute carrier family 11 member 1	Homo sapiens	0-7
11909746-1	2002	Slc11a1 (solute carrier family 11 member 1) (formerly Nramp1) modulation of iron metabolism in macrophages plays an important role in early phase macrophage activation, and therefore host innate immunity.	Iron	76-80	solute carrier family 11 member 1	Homo sapiens	9-42
11909746-1	2002	Slc11a1 (solute carrier family 11 member 1) (formerly Nramp1) modulation of iron metabolism in macrophages plays an important role in early phase macrophage activation, and therefore host innate immunity.	Iron	76-80	solute carrier family 11 member 1	Homo sapiens	54-60
11909746-2	2002	This review focuses on the role of Nramp1 in intramacrophage iron metabolism, with emphasis on the two prevailing mechanisms of Nramp1 modulation of iron metabolism in macrophages.	Iron	61-65	solute carrier family 11 member 1	Homo sapiens	35-41
11909746-2	2002	This review focuses on the role of Nramp1 in intramacrophage iron metabolism, with emphasis on the two prevailing mechanisms of Nramp1 modulation of iron metabolism in macrophages.	Iron	149-153	solute carrier family 11 member 1	Homo sapiens	128-134
11958437-5	2002	Hydrogen peroxide possibly converted to hydroxyl radical by iron due to lower transferrin level might have led to increased serum lipid peroxidation in patients with rheumatoid arthritis.	Iron	60-64	transferrin	Homo sapiens	78-89
11854449-0	2002	Non-ahr gene susceptibility Loci for porphyria and liver injury induced by the interaction of "dioxin" with iron overload in mice.	Iron	108-112	aryl-hydrocarbon receptor	Mus musculus	4-7
11952908-3	2002	A previous study showed that, in the Gram-positive human pathogen Staphylococcus aureus, a cell surface-associated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) enzyme (Gap, or Tpn) is capable of binding human transferrin, representing a potential means by which this bacterium is able to access iron in vivo.	Iron	299-303	transferrin	Homo sapiens	213-224
11902060-2	2002	Effective iron replacement and maintenance play a vital role in efficient use of EPO.	Iron	10-14	erythropoietin	Homo sapiens	81-84
12071600-1	2002	We conducted a prospective study to determine the effect of intravenous low-dose iron administration in chronic hemodialysis patients treated with recombinant human erythropoietin (rHuEPO).	Iron	81-85	erythropoietin	Homo sapiens	165-179
11849066-7	2002	The energy difference of two phases is determined by the ligand field strength around Co(II) ions, which can be controlled by Co/Fe.	Iron	129-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
11829747-8	2002	Iron regulation of SMF3 was dramatically reduced, but not completely eliminated, in strains lacking both the AFT1 and AFT2 iron regulatory factors.	Iron	0-4	Aft2p	Saccharomyces cerevisiae S288C	118-122
11853459-1	2002	Heme oxygenase (HO) catalyzes the O(2)- and NADPH-cytochrome P450 reductase-dependent conversion of heme to biliverdin, Fe, and CO through a process in which the heme participates both as a prosthetic group and as a substrate.	Iron	120-122	cytochrome p450 oxidoreductase	Homo sapiens	44-75
11841920-0	2002	Iron regulation of hepatic macrophage TNFalpha expression.	Iron	0-4	tumor necrosis factor	Homo sapiens	38-46
11829747-8	2002	Iron regulation of SMF3 was dramatically reduced, but not completely eliminated, in strains lacking both the AFT1 and AFT2 iron regulatory factors.	Iron	123-127	Aft2p	Saccharomyces cerevisiae S288C	118-122
11815325-8	2002	The iron status of transferrin CC and CD subjects was similar.	Iron	4-8	transferrin	Homo sapiens	19-30
11814359-7	2002	The isolated C-lobe so obtained displayed spectroscopic and kinetic features of the C-lobe in native transferrin and was competent as an iron donor for K562 cells to which it bound in saturable fashion inhibitable by native diferric transferrin.	Iron	137-141	transferrin	Homo sapiens	101-112
11814359-7	2002	The isolated C-lobe so obtained displayed spectroscopic and kinetic features of the C-lobe in native transferrin and was competent as an iron donor for K562 cells to which it bound in saturable fashion inhibitable by native diferric transferrin.	Iron	137-141	transferrin	Homo sapiens	233-244
11814359-8	2002	Since the N-lobe by itself will neither bind nor donate iron to cells, the primary receptor-recognition site of transferrin resides in its C-lobe.	Iron	56-60	transferrin	Homo sapiens	112-123
11815325-1	2002	BACKGROUND: Transferrin is the major iron binding protein in human plasma.	Iron	37-41	transferrin	Homo sapiens	12-23
11960684-1	2002	The human transferrin receptor (TfR) and its ligand, the serum iron carrier transferrin, serve as a model system for endocytic receptors.	Iron	63-67	transferrin	Homo sapiens	10-21
11815325-2	2002	In black persons, the transferrin CD phenotype has been associated with alterations in certain markers of iron status.	Iron	106-110	transferrin	Homo sapiens	22-33
11804970-9	2002	Iron deficiency increased levels of tumor necrosis factor alpha (TNFalpha) only in the trophoblast giant cells of the placenta.	Iron	0-4	tumor necrosis factor	Rattus norvegicus	36-63
11815325-3	2002	OBJECTIVE: We studied vitamin C status in a Zimbabwean population according to transferrin phenotype because vitamin C metabolism is influenced by iron-driven oxidative stress.	Iron	147-151	transferrin	Homo sapiens	79-90
11854657-9	2002	Plasma iron concentration increased in the low erythropoietin dose group but not in the control or high erythropoietin dose groups.	Iron	7-11	erythropoietin	Homo sapiens	47-61
11804970-9	2002	Iron deficiency increased levels of tumor necrosis factor alpha (TNFalpha) only in the trophoblast giant cells of the placenta.	Iron	0-4	tumor necrosis factor	Rattus norvegicus	65-73
11828552-1	2002	AIM: To test whether the activities of erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) can be affected by oral iron (OI) treatment, parenteral iron (PI) treatment, and parenteral iron treatment with vitamin E supplementation (PIE) in iron deficiency anemia.	Iron	138-142	superoxide dismutase 1	Homo sapiens	73-76
11805012-0	2002	Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies.	Iron	21-25	transferrin	Homo sapiens	40-51
11805012-0	2002	Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies.	Iron	58-62	transferrin	Homo sapiens	40-51
11805012-1	2002	BACKGROUND: A microwell modification of the bleomycin assay for determining non-transferrin-bound iron (NTBI) was evaluated and compared with a chelation method.	Iron	98-102	transferrin	Homo sapiens	80-91
11805012-5	2002	NTBI results were also compared with transferrin saturation and the distribution of transferrin iron forms by urea-polyacrylamide gel electrophoresis.	Iron	96-100	transferrin	Homo sapiens	84-95
11805012-14	2002	When hemolyzed samples were excluded, bleomycin-detectable iron was found only when the transferrin saturation was &gt;80%, suggesting high specificity.	Iron	59-63	transferrin	Homo sapiens	88-99
11863124-0	2002	Reduction in erythropoietin doses by the use of chronic intravenous iron supplementation in iron-replete hemodialysis patients.	Iron	68-72	erythropoietin	Homo sapiens	13-27
11863124-0	2002	Reduction in erythropoietin doses by the use of chronic intravenous iron supplementation in iron-replete hemodialysis patients.	Iron	92-96	erythropoietin	Homo sapiens	13-27
11828552-1	2002	AIM: To test whether the activities of erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) can be affected by oral iron (OI) treatment, parenteral iron (PI) treatment, and parenteral iron treatment with vitamin E supplementation (PIE) in iron deficiency anemia.	Iron	170-174	superoxide dismutase 1	Homo sapiens	73-76
11828552-1	2002	AIM: To test whether the activities of erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) can be affected by oral iron (OI) treatment, parenteral iron (PI) treatment, and parenteral iron treatment with vitamin E supplementation (PIE) in iron deficiency anemia.	Iron	170-174	superoxide dismutase 1	Homo sapiens	73-76
11828552-11	2002	CONCLUSION: Oral iron treatment improved the iron deficiency anemia and recovered antioxidant defense system by increasing SOD activity and maintaining GSH-Px activity at normal level.	Iron	17-21	superoxide dismutase 1	Homo sapiens	123-126
11882623-1	2002	Heme oxygenase enzymes (HO-1 and HO-2) catalyze the conversion of heme to biliverdin, free iron, and carbon monoxide (CO).	Iron	91-95	heme oxygenase 2	Rattus norvegicus	33-37
11846778-3	2002	The Culex AO sequence contains a molybdopterin cofactor binding domain and two iron-sulfur centres.	Iron	79-83	uncharacterized protein LOC6054570	Culex quinquefasciatus	10-12
11935295-1	2002	The non-covalent association of beta 2-microglobulin with MHC class I molecules and MHC class I-type molecules such as FcRn or the hemochromatosis protein (HFE) is of major importance for their function, i.e., antigen presentation, IgG transport, and regulation of iron uptake, respectively.	Iron	265-269	Fc gamma receptor and transporter	Homo sapiens	119-123
11707449-5	2002	These findings indicate that the movement of the iron-sulfur subunit is composed of two discrete parts: a "micro-movement" at the cytochrome b interface, during which the [2Fe-2S] cluster interacts with ubihydroquinone oxidation site occupants and catalyzes ubihydroquinone oxidation, and a "macro-movement," during which the cluster domain swings away from cytochrome b interface, crosses the ef loop, and reaches a position close to cytochrome c(1) heme, to which it ultimately transfers an electron.	Iron	49-53	cytochrome c, somatic	Homo sapiens	435-447
11818402-12	2002	Iron accumulation was preceded by Tf degradation, as revealed by immunohistochemistry and Western blot analysis.	Iron	0-4	transferrin	Rattus norvegicus	34-36
11842150-1	2002	Chlamydomonas reinhardtii activates Cpx1, Cyc6, and Crd1, encoding, respectively, coproporphyrinogen oxidase, cytochrome c(6), and a novel di-iron enzyme when transferred to oxygen-deficient growth conditions.	Iron	142-146	uncharacterized protein	Chlamydomonas reinhardtii	52-56
11807826-0	2002	Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.	Iron	83-87	iron responsive element binding protein 2	Homo sapiens	19-23
11807826-6	2002	These results all point to the direct effect of the interaction of HFE with transferrin receptor in lowering the intracellular labile iron pool and establishing a new set point for iron regulation within the cell.	Iron	134-138	transferrin	Homo sapiens	76-87
11807826-6	2002	These results all point to the direct effect of the interaction of HFE with transferrin receptor in lowering the intracellular labile iron pool and establishing a new set point for iron regulation within the cell.	Iron	181-185	transferrin	Homo sapiens	76-87
11814575-11	2002	Our results suggest that a high-affinity Tf-R not only ensures efficient Tf uptake, but is also required to allow sufficient iron uptake by the trypanosome in the presence of anti-Tf-R antibodies.	Iron	125-129	transferrin receptor	Canis lupus familiaris	41-45
11814575-11	2002	Our results suggest that a high-affinity Tf-R not only ensures efficient Tf uptake, but is also required to allow sufficient iron uptake by the trypanosome in the presence of anti-Tf-R antibodies.	Iron	125-129	transferrin receptor	Canis lupus familiaris	180-184
11750985-3	2002	As several lines of evidence indicate that oxidative stress and free radical damage occur in AD, the transferrin gene (TF) has been suggested as a candidate locus for AD since it is the major transport protein for iron, which itself is a major factor in free radical generation.	Iron	214-218	transferrin	Homo sapiens	101-112
11806714-1	2002	A range of novel 3-hydroxypyridin-4-ones with different R(2) substitutents has been synthesized for the investigation of the structure-activity relationship between the chemical nature of the ligand and the inhibitory activity of the iron-containing metalloenzyme 5-lipoxygenase.	Iron	234-238	arachidonate 5-lipoxygenase	Homo sapiens	264-278
12014358-2	2002	Recently the soluble serum transferrin receptor (sTfR) has been introduced as a promising new tool for diagnosing iron depletion.	Iron	114-118	transferrin	Homo sapiens	27-38
12572988-0	2002	Role of non-transferrin-bound iron in the pathogenesis of iron overload and toxicity.	Iron	30-34	transferrin	Homo sapiens	12-23
12145469-0	2002	Increased non-transferrin-bound serum iron in megaloblastic anaemia.	Iron	38-42	transferrin	Homo sapiens	14-25
12572988-0	2002	Role of non-transferrin-bound iron in the pathogenesis of iron overload and toxicity.	Iron	58-62	transferrin	Homo sapiens	12-23
11838274-3	2002	Iron-saturated transferrin enhances M. avium growth, whereas apotransferrin inhibits mycobacterial replication.	Iron	0-4	transferrin	Homo sapiens	15-26
11782816-2	2002	Iron not bound in erythrocyte hemoglobin is transported by the plasma iron transport protein transferrin (Tf) and bound within cells by ferritin.	Iron	0-4	transferrin	Homo sapiens	93-104
11792187-4	2002	Cells treated with IL-1 beta expressed E-selectin and showed a 100-200 times higher binding of CLIO particles (83-104 ng iron/million cells) than control cells.	Iron	121-125	interleukin 1 beta	Homo sapiens	19-28
11786337-1	2002	Photosystem I reduction by the soluble metalloproteins cytochrome c(6) and plastocyanin, which are alternatively synthesized by some photosynthetic organisms depending on the relative availability of copper and iron, has been investigated in cyanobacteria, green algae and plants.	Iron	211-215	cytochrome c, somatic	Homo sapiens	55-67
11908640-1	2002	Lactoferrin shares many structural and functional features with serum transferrin, including an ability to bind iron very tightly, but reversibly, a highly-conserved three-dimensional structure, and essentially identical iron-binding sites.	Iron	112-116	transferrin	Homo sapiens	70-81
11803177-2	2002	Precise quantitation of iron status and determination of iron incorporation into erythrocytes are important in monitoring therapy for anemia in premature infants, especially when treating with recombinant human erythropoietin (rhEPO).	Iron	57-61	erythropoietin	Homo sapiens	211-225
12401957-3	2002	Iron has also been shown to mediate the in vitro toxicity of amyloid-beta peptide, and the presence of iron in most in vitro systems could underlie the toxicity that is normally attributed to amyloid-beta in these studies.	Iron	0-4	amyloid beta precursor protein	Homo sapiens	61-73
11751551-4	2002	The decrease in absorbance (as transferrin extracts iron from the iron-dye complex) is directly proportional to the TIBC.	Iron	52-56	transferrin	Homo sapiens	31-42
11751551-4	2002	The decrease in absorbance (as transferrin extracts iron from the iron-dye complex) is directly proportional to the TIBC.	Iron	66-70	transferrin	Homo sapiens	31-42
12139409-4	2002	The transferrin receptor-transferrin pathway is the main mechanism by which cells take up iron.	Iron	90-94	transferrin	Homo sapiens	4-15
12139409-4	2002	The transferrin receptor-transferrin pathway is the main mechanism by which cells take up iron.	Iron	90-94	transferrin	Homo sapiens	25-36
12139409-5	2002	The recently identified homolog of transferrin receptor, its characterization and its role in iron metabolism is the subject of this review.	Iron	94-98	transferrin	Homo sapiens	35-46
11796431-10	2002	Serum iron levels and transferrin saturation were negatively related to CRP (r = -0.8 and r = -0.7, respectively; p &lt; 0.01) and erythrocyte sedimentation rate (r = -0.5 and r = -0.4, respectively; p &lt; 0.05).	Iron	6-10	C-reactive protein	Homo sapiens	72-75
12401947-10	2002	The upregulated expression of transferrin receptors on BCECs in the second and third postnatal week is compatible with a high need for iron at this age.	Iron	135-139	transferrin	Rattus norvegicus	30-41
12401947-11	2002	The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards.	Iron	96-100	transferrin	Rattus norvegicus	13-24
12401947-11	2002	The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards.	Iron	240-244	transferrin	Rattus norvegicus	13-24
12401957-3	2002	Iron has also been shown to mediate the in vitro toxicity of amyloid-beta peptide, and the presence of iron in most in vitro systems could underlie the toxicity that is normally attributed to amyloid-beta in these studies.	Iron	103-107	amyloid beta precursor protein	Homo sapiens	192-204
12401948-4	2002	When expressed as the volume of distribution (Vd), which represents the volume of plasma from which the transferrin and iron were derived, the results for iron were greater than those of transferrin as early as 7 min after injection and the difference increased rapidly with time, especially in the younger animals.	Iron	155-159	transferrin	Rattus norvegicus	104-115
12401948-5	2002	A very similar time course was found for uptake by bone marrow (femurs) where iron uptake involves receptor-mediated endocytosis of Fe-transferrin, release of iron in the cell and recycling of apo-transferrin to the blood.	Iron	78-82	transferrin	Rattus norvegicus	135-146
12401948-5	2002	A very similar time course was found for uptake by bone marrow (femurs) where iron uptake involves receptor-mediated endocytosis of Fe-transferrin, release of iron in the cell and recycling of apo-transferrin to the blood.	Iron	78-82	transferrin	Rattus norvegicus	197-208
12401957-4	2002	In contrast, several recent studies have suggested that amyloid-beta may decrease oxidative stress and decrease the toxicity of iron.	Iron	128-132	amyloid beta precursor protein	Homo sapiens	56-68
12401948-6	2002	It is concluded that, during transport of transferrin-bound plasma iron into the brain, a similar process occurs in brain capillary endothelial cells (BCECs) and that transcytosis of transferrin into the brain interstitium is only a minor pathway.	Iron	67-71	transferrin	Rattus norvegicus	42-53
11755321-1	2002	We have investigated the effect of iron overload on the expression of mouse GSTA1, A4, M1, and P1 in liver, the main iron storage site during iron overload, and in kidney.	Iron	35-39	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	76-81
12401948-6	2002	It is concluded that, during transport of transferrin-bound plasma iron into the brain, a similar process occurs in brain capillary endothelial cells (BCECs) and that transcytosis of transferrin into the brain interstitium is only a minor pathway.	Iron	67-71	transferrin	Rattus norvegicus	183-194
12401948-7	2002	Also, the high rate of iron transport into the brain in young animals, when iron requirements are high due to rapid growth of the brain, is a consequence of the level of expression and rate of recycling of transferrin receptors on BCECs.	Iron	23-27	transferrin	Rattus norvegicus	206-217
12401948-7	2002	Also, the high rate of iron transport into the brain in young animals, when iron requirements are high due to rapid growth of the brain, is a consequence of the level of expression and rate of recycling of transferrin receptors on BCECs.	Iron	76-80	transferrin	Rattus norvegicus	206-217
12401949-2	2002	Previous studies of regulation of the cytosolic iron sensor, iron-regulatory protein 2 (IRP2), indicate that iron-dependent oxidation triggers ubiquitination and proteasomal degradation of IRP2.	Iron	48-52	iron responsive element binding protein 2	Homo sapiens	61-86
12401949-2	2002	Previous studies of regulation of the cytosolic iron sensor, iron-regulatory protein 2 (IRP2), indicate that iron-dependent oxidation triggers ubiquitination and proteasomal degradation of IRP2.	Iron	48-52	iron responsive element binding protein 2	Homo sapiens	88-92
12401949-2	2002	Previous studies of regulation of the cytosolic iron sensor, iron-regulatory protein 2 (IRP2), indicate that iron-dependent oxidation triggers ubiquitination and proteasomal degradation of IRP2.	Iron	48-52	iron responsive element binding protein 2	Homo sapiens	189-193
12401949-2	2002	Previous studies of regulation of the cytosolic iron sensor, iron-regulatory protein 2 (IRP2), indicate that iron-dependent oxidation triggers ubiquitination and proteasomal degradation of IRP2.	Iron	61-65	iron responsive element binding protein 2	Homo sapiens	88-92
12401949-2	2002	Previous studies of regulation of the cytosolic iron sensor, iron-regulatory protein 2 (IRP2), indicate that iron-dependent oxidation triggers ubiquitination and proteasomal degradation of IRP2.	Iron	61-65	iron responsive element binding protein 2	Homo sapiens	189-193
11755321-2	2002	In iron-overloaded animals, mRNA and protein levels of GSTA1, A4, and M1 were increased in liver.	Iron	3-7	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	55-60
11755321-7	2002	These data demonstrate that GSTA1 and M1 are differentially regulated in liver and kidney while GSTA4 is induced in both organs during iron overload.	Iron	135-139	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	28-33
11821639-0	2002	ACE inhibitor-associated cough lessened with iron supplementation.	Iron	45-49	angiotensin I converting enzyme	Homo sapiens	0-3
11823983-6	2002	This contrasts to the predominant iron metabolic disorders of HO-1--targeted mice with a long survival.	Iron	34-38	heme oxygenase 1	Mus musculus	62-66
11834219-0	2002	Effect of different durations of exercise on transferrin-bound iron uptake by rat erythroblast.	Iron	63-67	transferrin	Rattus norvegicus	45-56
11804661-4	2002	RESULTS: The uptake of iron from diferric transferrin (Trf) was extremely low, while iron as ferric-ammonium-citrate (FAC) was taken up readily, especially by Hep3B cells.	Iron	23-27	transferrin	Homo sapiens	42-53
11804661-4	2002	RESULTS: The uptake of iron from diferric transferrin (Trf) was extremely low, while iron as ferric-ammonium-citrate (FAC) was taken up readily, especially by Hep3B cells.	Iron	23-27	transferrin	Homo sapiens	55-58
11834219-3	2002	At the end of experiments, the erythroblasts were isolated for Tf binding assay and transferrin-bound iron (Tf-Fe) uptake.	Iron	102-106	transferrin	Rattus norvegicus	84-95
11812905-13	2002	In the presence of oxygen and iron, it may induce oxidative modifications that target HIF-1 alpha for ubiquitination and degradation.	Iron	30-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-97
12091599-16	2002	Erythropoietin replacement therapy can correct the anaemia in almost all iron replete patients providing enough hormone is given, functional iron deficiency is avoided, aluminium levels and parathyroid toxicities are controlled and that no de novo haematological condition that affects erythropoiesis or red blood cell survival develops.	Iron	73-77	erythropoietin	Homo sapiens	0-14
11796829-0	2002	Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration.	Iron	9-13	angiotensinogen	Rattus norvegicus	64-78
11796829-3	2002	From findings in cells from heme oxygenase-1 (HO-1)-deficient mice, HO-1 is postulated to prevent abnormal intracellular iron accumulation.	Iron	121-125	heme oxygenase 1	Mus musculus	28-44
11796829-3	2002	From findings in cells from heme oxygenase-1 (HO-1)-deficient mice, HO-1 is postulated to prevent abnormal intracellular iron accumulation.	Iron	121-125	heme oxygenase 1	Mus musculus	46-50
11796829-8	2002	Prussian blue staining revealed the distinct deposits of iron in the proximal tubular epithelial cells after angiotensin II administration.	Iron	57-61	angiotensinogen	Rattus norvegicus	109-123
11796829-11	2002	Treatment of angiotensin II-infused rats with an iron chelator, deferoxamine, blocked the abnormal iron deposition in kidneys and also the induced expression of HO-1 and ferritin expression.	Iron	49-53	angiotensinogen	Rattus norvegicus	13-27
11796829-11	2002	Treatment of angiotensin II-infused rats with an iron chelator, deferoxamine, blocked the abnormal iron deposition in kidneys and also the induced expression of HO-1 and ferritin expression.	Iron	99-103	angiotensinogen	Rattus norvegicus	13-27
11796829-13	2002	These results suggest that angiotensin II causes renal injury, in part, by inducing the deposition of iron in the kidney.	Iron	102-106	angiotensinogen	Rattus norvegicus	27-41
11773494-0	2002	Does iron depletion induced by erythropoietin slow the progression of chronic kidney disease?	Iron	5-9	erythropoietin	Homo sapiens	31-45
12091601-3	2002	iron and recombinant human erythropoietin (rHuEPO) therapy, have furthered our understanding of the relationship between erythropoietin, iron, and erythropoiesis.	Iron	0-4	erythropoietin	Homo sapiens	121-135
12091601-3	2002	iron and recombinant human erythropoietin (rHuEPO) therapy, have furthered our understanding of the relationship between erythropoietin, iron, and erythropoiesis.	Iron	137-141	erythropoietin	Homo sapiens	27-41
12091602-7	2002	In renal disease, the failure of the erythropoietin positive feedback mechanism can be readily and directly remedied; recombinant human erythropoietin therapy can replace the missing erythropoietin, but this will be negated if iron supply to the erythroid marrow falls short of demand.	Iron	227-231	erythropoietin	Homo sapiens	37-51
11812914-6	2002	Adequate monitoring of iron status and iron supplementation in patients with CKD will result in a more efficient epoetin response.	Iron	23-27	erythropoietin	Homo sapiens	113-120
12091602-7	2002	In renal disease, the failure of the erythropoietin positive feedback mechanism can be readily and directly remedied; recombinant human erythropoietin therapy can replace the missing erythropoietin, but this will be negated if iron supply to the erythroid marrow falls short of demand.	Iron	227-231	erythropoietin	Homo sapiens	136-150
12091602-7	2002	In renal disease, the failure of the erythropoietin positive feedback mechanism can be readily and directly remedied; recombinant human erythropoietin therapy can replace the missing erythropoietin, but this will be negated if iron supply to the erythroid marrow falls short of demand.	Iron	227-231	erythropoietin	Homo sapiens	136-150
11812914-6	2002	Adequate monitoring of iron status and iron supplementation in patients with CKD will result in a more efficient epoetin response.	Iron	39-43	erythropoietin	Homo sapiens	113-120
12091609-1	2002	Iron supplementation is essential for adequate response to recombinant human erythropoietin (rHuEPO) or darbepoetin alfa.	Iron	0-4	erythropoietin	Homo sapiens	77-91
12448934-5	2002	Iron was present in form of transferrin and ferritin, main amount of copper was bound to ceruloplasmin and selenium compounds were identified as selenoproteine P and glutathione peroxidase.	Iron	0-4	transferrin	Homo sapiens	28-39
12091610-1	2002	Iron supplementation is probably the most important factor affecting response to treatment with recombinant human erythropoietin (rHuEPO) in patients with renal anaemia.	Iron	0-4	erythropoietin	Homo sapiens	114-128
11929146-1	2002	OBJECTIVE: Sufficient iron substitution leads to a decrease in the required recombinant human erythropoietin (rHuEPO) dose and/or an increased hematocrit in dialysis patients.	Iron	22-26	erythropoietin	Homo sapiens	94-108
12611338-6	2002	The pattern of the found changes leads to the conclusion that patients with acutely progressive tuberculosis develop iron-redistributing anemia caused by the changes in the amount and quality of transferrin, iron binding during free radical processes and mobilization of the antioxidant defense system rather than true iron deficiency.	Iron	117-121	transferrin	Homo sapiens	195-206
11981450-1	2002	Iron regulatory proteins, IRP1 and IRP2, are cytoplasmic proteins of the iron-sulfur cluster isomerase family and serve as major post-transcriptional regulators of cellular iron metabolism.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	35-39
11981450-1	2002	Iron regulatory proteins, IRP1 and IRP2, are cytoplasmic proteins of the iron-sulfur cluster isomerase family and serve as major post-transcriptional regulators of cellular iron metabolism.	Iron	73-77	iron responsive element binding protein 2	Homo sapiens	35-39
11981450-1	2002	Iron regulatory proteins, IRP1 and IRP2, are cytoplasmic proteins of the iron-sulfur cluster isomerase family and serve as major post-transcriptional regulators of cellular iron metabolism.	Iron	173-177	iron responsive element binding protein 2	Homo sapiens	35-39
11981450-3	2002	IRP1 and IRP2 respond to alterations in intracellular iron levels, but also to other signals such as nitric oxide (NO) and reactive oxygen species (ROS).	Iron	54-58	iron responsive element binding protein 2	Homo sapiens	9-13
11981450-4	2002	The redox regulation of IRP1 and IRP2 provides direct links between the control of iron homeostasis and oxidative stress.	Iron	83-87	iron responsive element binding protein 2	Homo sapiens	33-37
12688510-0	2002	Iron uptake by melanoma cells from the soluble form of the transferrin homologue, melanotransferrin.	Iron	0-4	transferrin	Homo sapiens	59-70
12028655-1	2002	A 14-year-old girl demonstrated increased iron concentration and transferrin saturation, suggesting iron overload of unknown origin.	Iron	100-104	transferrin	Homo sapiens	65-76
11722958-1	2001	BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron.	Iron	122-126	transferrin	Homo sapiens	18-29
11747438-1	2001	The crystal structure of the iron-free (apo) form of the Haemophilus influenzae Fe(3+)-binding protein (hFbp) has been determined to 1.75 A resolution.	Iron	29-33	ECB2	Homo sapiens	104-108
11744327-3	2001	Addition of ethanol or an unsaturated fatty acid such as arachidonic acid or iron was toxic to the CYP2E1-expressing cells but not control cells.	Iron	77-81	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	99-105
11744327-5	2001	Apoptosis occurred in the CYP2E1-expressing cells exposed to ethanol, arachidonic acid, or iron.	Iron	91-95	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	26-32
11779098-1	2001	In the present investigation, we studied the effect of recombinant human erythropoietin (r-HuEPO) on serum malondialdehyde (MDA) as an index of lipid peroxidation, related to iron-catalyzed free radical reaction and erythrocyte superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities in very-low-birth weight (VLBW) infants.	Iron	175-179	erythropoietin	Homo sapiens	73-87
11689290-0	2001	Targeting HER-2/neu-overexpressing breast cancer cells by an antisense iron responsive element-directed gene expression.	Iron	71-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	10-19
11689290-2	2001	To target breast cancer cells that overexpress HER-2/neu mRNA, we previously described a novel strategy that combines the principle of antisense (AS) and translational inhibitory activity conferred by an iron-responsive element (IRE) (AS-IRE).	Iron	204-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-56
11689290-4	2001	Using AS-IRE4 as our model, we demonstrated that it is regulated by iron, and importantly, such regulation is impaired in HER-2/neu-overexpressing breast cancer cells.	Iron	68-72	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-127
11689290-4	2001	Using AS-IRE4 as our model, we demonstrated that it is regulated by iron, and importantly, such regulation is impaired in HER-2/neu-overexpressing breast cancer cells.	Iron	68-72	erb-b2 receptor tyrosine kinase 2	Homo sapiens	128-131
11747438-5	2001	In solution, apo-hFbp bound phosphate with an affinity K(d) of 2.3 x 10(-3) M. The presence of this ternary binding site anion appears to arrange the C-terminal iron-binding residues conducive to complementary binding to Fe(3+), while residues in the N-terminal binding domain must undergo induced fit to accommodate the Fe(3+) ligand.	Iron	161-165	ECB2	Homo sapiens	17-21
11730343-0	2001	A fluorescence-based one-step assay for serum non-transferrin-bound iron.	Iron	68-72	transferrin	Homo sapiens	50-61
11730343-1	2001	We introduce a method for monitoring non-transferrin-bound iron (NTBI), a labile and potentially toxic form of serum iron associated with imbalanced iron metabolism.	Iron	59-63	transferrin	Homo sapiens	41-52
11730343-1	2001	We introduce a method for monitoring non-transferrin-bound iron (NTBI), a labile and potentially toxic form of serum iron associated with imbalanced iron metabolism.	Iron	117-121	transferrin	Homo sapiens	41-52
11730343-1	2001	We introduce a method for monitoring non-transferrin-bound iron (NTBI), a labile and potentially toxic form of serum iron associated with imbalanced iron metabolism.	Iron	117-121	transferrin	Homo sapiens	41-52
11730343-2	2001	The assay employs fluorescein-labeled apotransferrin (Fl-aTf), which undergoes fluorescence quenching upon binding iron.	Iron	115-119	glial cell derived neurotrophic factor	Homo sapiens	57-60
11730343-6	2001	This metal, like iron, binds to Fl-aTf, but it neither quenches its fluorescence nor interferes with quenching by iron.	Iron	17-21	glial cell derived neurotrophic factor	Homo sapiens	35-38
11734641-7	2001	The AFT2-1(up) allele also increased the uptake of (59)Fe in an aft1Delta strain.	Iron	55-57	Aft2p	Saccharomyces cerevisiae S288C	4-8
11734641-12	2001	The wild-type allele of AFT2 activated transcription in response to growth under low-iron conditions.	Iron	85-89	Aft2p	Saccharomyces cerevisiae S288C	24-28
11734641-13	2001	Together, these data suggest that yeast has a second regulatory pathway for the iron regulon, with AFT1 and AFT2 playing partially redundant roles.	Iron	80-84	Aft2p	Saccharomyces cerevisiae S288C	108-112
11761470-5	2001	Induction of ferritin-H and -L gene expression may also limit iron catalyzed hydroxyl radical formation and consequent oxidative damage to lipids, proteins, and nucleic acids.	Iron	62-66	ferritin mitochondrial	Mus musculus	13-30
11746204-3	2001	NO production was monitored by NO2 concentration in supernatants based on the Griess reaction; while the semi-quantitative RT-PCR was applied to detect the inducible nitric oxide synthase (iNOS) mRNA level induced by NTA-Fe and LPS together.	Iron	220-223	nitric oxide synthase 2	Homo sapiens	156-187
11746204-3	2001	NO production was monitored by NO2 concentration in supernatants based on the Griess reaction; while the semi-quantitative RT-PCR was applied to detect the inducible nitric oxide synthase (iNOS) mRNA level induced by NTA-Fe and LPS together.	Iron	220-223	nitric oxide synthase 2	Homo sapiens	189-193
11705947-7	2001	The mammalian Fe(III)-binding compounds hemin and transferrin served both as substrates for the ferric reductase and as iron sources for yeast-phase growth at neutral pH.	Iron	120-124	transferrin	Homo sapiens	50-61
11705913-4	2001	Under iron-replete growth conditions FeSOD and catalase activities were maximized.	Iron	6-10	catalase	Homo sapiens	47-55
11705947-8	2001	In the case of transferrin, there was a correlation between the level of iron saturation and efficacy for both of these functions.	Iron	73-77	transferrin	Homo sapiens	15-26
11705913-6	2001	FeSOD and catalase activity decreased under iron-limited growth conditions, whereas MnSOD activity appeared.	Iron	44-48	catalase	Homo sapiens	10-18
11738096-3	2001	We hypothesized that the genetic haptoglobin (Hp) polymorphism, because of its effect on iron metabolism, could be a modifying factor that influences the clinical presentation of hereditary hemochromatosis.	Iron	89-93	haptoglobin	Homo sapiens	33-44
11737617-12	2001	CONCLUSIONS: CHr is a markedly more stable analyte than serum ferritin or transferrin saturation, and iron management based on CHr results in similar hematocrit and epoetin dosing while significantly reducing IV iron exposure.	Iron	102-106	erythropoietin	Homo sapiens	165-172
11731222-1	2001	Conventional cardiopulmonary bypass surgery (CCPB) increases the iron loading of plasma transferrin often to a state of plasma iron overload, with the presence of low molecular mass iron.	Iron	65-69	transferrin	Homo sapiens	88-99
11751745-0	2001	Iron supplementation in ACE inhibition as a treatment for cough: is it really inoffensive?	Iron	0-4	angiotensin I converting enzyme	Homo sapiens	24-27
11734214-3	2001	This impaired induction was observed at iron levels in which increased activation of the redox-sensitive factor NF-kappaB was absent.	Iron	40-44	nuclear factor kappa B subunit 1	Homo sapiens	112-121
11788108-5	2001	This acidic environment during exercise (at or beyond anaerobic threshold) promotes oxygen release from hemoglobin and increases in PO(2) in tissues, as well as releases iron from transferrin.	Iron	15-19	transferrin	Homo sapiens	180-191
11675342-2	2001	In most cells, transferrin receptor-mediated endocytosis is a major pathway for cellular iron uptake.	Iron	89-93	transferrin	Homo sapiens	15-26
11731674-0	2001	Iron supplementation during erythropoietin treatment.	Iron	0-4	erythropoietin	Homo sapiens	28-42
11698570-0	2001	Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma.	Iron	60-64	tumor protein p53	Homo sapiens	21-24
11487579-4	2001	Unfolding by guanidine or urea weakens the Fe-Met bond, and the reduced unfolded cytochrome c easily binds CO and other heme ligands, which would react slowly or not at all with the native protein.	Iron	43-45	cytochrome c, somatic	Homo sapiens	81-93
11487579-6	2001	This approach is complicated by the breakage of the proximal His-Fe bond that may occur as a consequence of CO photodissociation in the unfolded cytochrome c because of the so-called base elimination mechanism.	Iron	65-67	cytochrome c, somatic	Homo sapiens	145-157
11705390-1	2001	The 1.9 A X-ray crystal structure of human myeloperoxidase complexed with cyanide (R = 0.175, R(free) = 0.215) indicates that cyanide binds to the heme iron with a bent Fe-C-N angle of approximately 157 degrees, and binding is accompanied by movement of the iron atom by 0.2 A into the porphyrin plane.	Iron	152-156	myeloperoxidase	Homo sapiens	43-58
11705390-1	2001	The 1.9 A X-ray crystal structure of human myeloperoxidase complexed with cyanide (R = 0.175, R(free) = 0.215) indicates that cyanide binds to the heme iron with a bent Fe-C-N angle of approximately 157 degrees, and binding is accompanied by movement of the iron atom by 0.2 A into the porphyrin plane.	Iron	258-262	myeloperoxidase	Homo sapiens	43-58
11686732-0	2001	Sulfur transfer from IscS to IscU: the first step in iron-sulfur cluster biosynthesis.	Iron	53-57	iron-sulfur cluster assembly enzyme	Homo sapiens	29-33
11517226-5	2001	In this study we show that recombinant, highly purified human and mouse p53R2 proteins contain an iron-tyrosyl free radical center, and both proteins form an active RNR complex with the human and mouse R1 proteins.	Iron	98-102	ribonucleotide reductase M2 B (TP53 inducible)	Mus musculus	72-77
11684551-1	2001	It is now recognized that the majority of patients on epoetin therapy require intravenous (IV) iron supplementation to maximize the response to treatment.	Iron	95-99	erythropoietin	Homo sapiens	54-61
11672431-9	2001	AtFer1 and AtFer3 are the two major genes expressed in response to treatment with an iron overload.	Iron	85-89	ferretin 1	Arabidopsis thaliana	0-6
11672431-9	2001	AtFer1 and AtFer3 are the two major genes expressed in response to treatment with an iron overload.	Iron	85-89	ferritin 3	Arabidopsis thaliana	11-17
11669588-4	2001	The transferrin saturation (serum iron/total iron binding capacity) in both sets of patients after surgery fell on average to levels that would be expected to impair subsequent red cell production.	Iron	34-38	transferrin	Homo sapiens	4-15
11669588-4	2001	The transferrin saturation (serum iron/total iron binding capacity) in both sets of patients after surgery fell on average to levels that would be expected to impair subsequent red cell production.	Iron	45-49	transferrin	Homo sapiens	4-15
11677039-10	2001	In particular, the total iron in the bone marrow was markedly increased at a few hours after the TBI, with a slight increase in transferrin and no increase in ferritin.	Iron	25-29	transferrin	Rattus norvegicus	128-139
11722747-10	2001	Three of the IdeR- and iron-repressed genes, mbtB, mbtI and rv3402c, were induced during M. tuberculosis infection of human THP-1 macrophages.	Iron	23-27	GLI family zinc finger 2	Homo sapiens	124-129
11682666-9	2001	iron requirements were higher in the patients dialysed through PTFE grafts compared with those with native AVF (Epo: 103.8+/-58.4 vs 81.0+/-44.5 U/kg/week, P=0.025; i.v.	Iron	0-4	erythropoietin	Homo sapiens	112-115
11846523-7	2001	This mechanism could be one manner in which E. histolytica acquires iron from the human host transferrin.	Iron	68-72	transferrin	Homo sapiens	93-104
11739637-4	2001	We found previously that, although zinc, another example of a metal substitute for iron, stabilized HIF-1alpha, it suppressed the formation of HIF-1 by blocking the nuclear translocation of ARNT.	Iron	83-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
11739637-4	2001	We found previously that, although zinc, another example of a metal substitute for iron, stabilized HIF-1alpha, it suppressed the formation of HIF-1 by blocking the nuclear translocation of ARNT.	Iron	83-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-105
11748751-1	2001	We report on two patients with pathologically proven neurodegeneration with brain iron accumulation type 1 (NBIA-1) with late onset and atypical presentations.	Iron	82-86	pantothenate kinase 2	Homo sapiens	108-114
11840762-9	2001	And, their serum IL-2 were (278.9 +/- 117.7) ng/L after supplementation, significantly higher than that before supplementation (161.6 +/- 90.3) ng/L and that in those supplemented with iron only (189.5 +/- 89.3) ng/L.	Iron	185-189	interleukin 2	Homo sapiens	17-21
11800564-1	2001	The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	63-67	transferrin	Homo sapiens	4-15
11800564-1	2001	The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	63-67	transferrin	Homo sapiens	26-28
11588029-0	2001	Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey.	Iron	48-52	transferrin	Homo sapiens	21-32
11588029-1	2001	In previous analyses of transferrin saturation data in African Americans and Caucasians from the second National Health and Nutrition Examination Survey (NHANES II), subpopulations were found consistent with population genetics for common loci that influence iron metabolism.	Iron	259-263	transferrin	Homo sapiens	24-35
11588029-2	2001	The goal of this new study was to determine if these transferrin saturation subpopulations have different levels of iron stores.	Iron	116-120	transferrin	Homo sapiens	53-64
11588029-7	2001	These results are consistent with the concept that population transferrin saturation subpopulations reflect different levels of storage iron.	Iron	136-140	transferrin	Homo sapiens	62-73
11576999-0	2001	p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator.	Iron	67-71	tumor protein p53	Homo sapiens	0-3
11696670-0	2001	Non-transferrin-bound iron in alcohol abusers.	Iron	22-26	transferrin	Homo sapiens	4-15
11696670-1	2001	BACKGROUND: Non-transferrin-bound iron, a low-molecular-weight iron complex capable of initiating free radical formation and lipid peroxidation, has been detected in the serum of animals experimentally fed with alcohol, but no data have been reported in alcohol abusers.	Iron	34-38	transferrin	Homo sapiens	16-27
11696670-1	2001	BACKGROUND: Non-transferrin-bound iron, a low-molecular-weight iron complex capable of initiating free radical formation and lipid peroxidation, has been detected in the serum of animals experimentally fed with alcohol, but no data have been reported in alcohol abusers.	Iron	63-67	transferrin	Homo sapiens	16-27
11696670-2	2001	The purpose of this study was to evaluate whether non-transferrin-bound iron is present in chronic alcohol abusers with liver involvement and whether alcohol plays any part in its appearance.	Iron	72-76	transferrin	Homo sapiens	54-65
11696670-4	2001	RESULTS: At presentation, non-transferrin-bound iron was detectable in 83.7% of active abusers but only in 21.2% of abstainers, and within the group of abusers, patients with cirrhosis had significantly higher non-transferrin-bound iron than patients without.	Iron	48-52	transferrin	Homo sapiens	30-41
11696670-4	2001	RESULTS: At presentation, non-transferrin-bound iron was detectable in 83.7% of active abusers but only in 21.2% of abstainers, and within the group of abusers, patients with cirrhosis had significantly higher non-transferrin-bound iron than patients without.	Iron	48-52	transferrin	Homo sapiens	214-225
11696670-5	2001	Non-transferrin-bound iron was present not only in patients with transferrin saturation &gt;45% but also in those with transferrin saturation &lt; or =45%.	Iron	22-26	transferrin	Homo sapiens	4-15
11696670-5	2001	Non-transferrin-bound iron was present not only in patients with transferrin saturation &gt;45% but also in those with transferrin saturation &lt; or =45%.	Iron	22-26	transferrin	Homo sapiens	65-76
11696670-5	2001	Non-transferrin-bound iron was present not only in patients with transferrin saturation &gt;45% but also in those with transferrin saturation &lt; or =45%.	Iron	22-26	transferrin	Homo sapiens	65-76
11696670-8	2001	CONCLUSIONS: Non-transferrin-bound iron could have a role in initiating or promoting alcohol-induced liver damage.	Iron	35-39	transferrin	Homo sapiens	17-28
11570867-0	2001	Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins.	Iron	133-137	transferrin	Homo sapiens	24-35
11570867-0	2001	Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins.	Iron	133-137	transferrin	Homo sapiens	99-110
11570867-1	2001	Proteins of the transferrin (Tf) family play a central role in iron homeostasis in vertebrates.	Iron	63-67	transferrin	Homo sapiens	16-27
11570867-1	2001	Proteins of the transferrin (Tf) family play a central role in iron homeostasis in vertebrates.	Iron	63-67	transferrin	Homo sapiens	29-31
11570867-4	2001	Surprisingly, mutagenesis of the histidine ligand, His249, to glutamine in the N-lobe half-molecule of human Tf (hTf/2N) shows that iron binding is destabilized and suggests that Gln249 does not bind to iron.	Iron	132-136	transferrin	Homo sapiens	109-111
11570867-4	2001	Surprisingly, mutagenesis of the histidine ligand, His249, to glutamine in the N-lobe half-molecule of human Tf (hTf/2N) shows that iron binding is destabilized and suggests that Gln249 does not bind to iron.	Iron	203-207	transferrin	Homo sapiens	109-111
11570867-8	2001	Examination of insect Tf sequences shows that the K206.K296 dilysine pair, which aids iron release from the N-lobes of vertebrate Tfs, is not present in the insect proteins.	Iron	86-90	transferrin	Homo sapiens	22-24
11591239-5	2001	In addition, it seems that reduced insulin sensitivity in meat-eaters is amenable to improvement by reducing body Fe.	Iron	114-116	insulin	Homo sapiens	35-42
11689493-7	2001	JAC1, an ortholog of hscB, and SSQ1, a paralog of hscA, have been shown to be required for iron-sulfur cluster assembly in mitochondria of Saccharomyces cerevisiae.	Iron	91-95	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	31-35
11692171-5	2001	RESULTS: We found a correlation between insulin resistance and red blood cell count, (r = 0.14 p &lt; 0.001), plasma haemoglobin (r = 0.16 p &lt; 0.001), haematocrit (r = 0.15 p &lt; 0.001) and plasma iron (r = 0.1 p &lt; 0.05) concentrations.	Iron	201-205	insulin	Homo sapiens	40-47
11692171-8	2001	Insulin resistance and BMI were significant and independent predictors of red blood cell count even when the analysis was adjusted for age, sex, waist-to-hip ratio, plasma iron and drug intake.	Iron	172-176	insulin	Homo sapiens	0-7
11576368-5	2001	RESULTS: With iron-dextran infusion, serum iron markedly increased (mean +/- SE, 42 +/- 4 vs. 311 +/- 92 microg/dL, P &lt; 0.0001) and exceeded the transferrin saturation of 100% in 22 out of 22 patients (pre 23 +/- 3 vs. post 165 +/- 8%, P &lt; 0.0001).	Iron	14-18	transferrin	Homo sapiens	148-159
11669158-8	2001	We suggest that soluble transferrin receptor is the method of choice in estimating the iron status of patients with an acute phase reaction.	Iron	87-91	transferrin	Homo sapiens	24-35
11576368-2	2001	However, rapid infusion of iron in excess of transferrin binding capacity can lead to the availability of unbound iron that can theoretically catalyze peroxidation of lipids, such as low-density lipoprotein (LDL), which when oxidatively modified is proinflammatory and promotes atherogenesis.	Iron	114-118	transferrin	Homo sapiens	45-56
11988032-2	2001	Their total body iron content at birth is low and gets further depleted by clinical practices such as uncompensated phlebotomy losses and exogenous erythropoietin administration during the neonatal period.	Iron	17-21	erythropoietin	Homo sapiens	148-162
11562436-10	2001	The results presented suggest that low concentrations of Fe and AA can act as priming or sensitizing factors for CYP2E1-induced injury in HepG2 cells, and such interactions may play a role in alcohol-induced liver injury.	Iron	57-59	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	113-119
11605781-1	2001	Iron supplementation is required for optimal response to erythropoietin (EPO) in hemodialysis patients.	Iron	0-4	erythropoietin	Homo sapiens	57-71
11605781-1	2001	Iron supplementation is required for optimal response to erythropoietin (EPO) in hemodialysis patients.	Iron	0-4	erythropoietin	Homo sapiens	73-76
11605781-2	2001	This is due to blood lost in the dialysis tubing after dialysis and the increased demand for iron by EPO therapy.	Iron	93-97	erythropoietin	Homo sapiens	101-104
11605781-13	2001	Maintenance IV iron reduced the dose of EPO required to maintain blood hemoglobin levels.	Iron	15-19	erythropoietin	Homo sapiens	40-43
11562436-0	2001	Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1.	Iron	24-28	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	80-86
11767488-11	2001	This could be explained by an increase of peripheral insulin resistance, mediated by the increase of iron deposits in these patients, and could be responsible for the increased risk of developing diabetes mellitus.	Iron	101-105	insulin	Homo sapiens	53-60
11551197-3	2001	The crystal structure of ATP A2 at 1.45 A resolution at 100 K showed a water molecule only 2.1 A from heme iron [Ostergaard, L., et al.	Iron	107-111	peroxidase 2	Arabidopsis thaliana	25-31
11571246-2	2001	The object of this study was to investigate whether adenovirus-mediated gene transfer of HO-1 in arteries reduces iron overload and inhibits lesion formation in apolipoprotein E (apoE)-deficient mice.	Iron	114-118	heme oxygenase 1	Mus musculus	89-93
11571246-3	2001	METHODS AND RESULTS: Infection of rat aortic smooth muscle cells with adenovirus carrying the human HO-1 gene (Adv-HO-1) resulted in a high-level expression of HO-1 protein, which effectively reduced the hemin-induced iron overload in these cells.	Iron	218-222	heme oxygenase 1	Mus musculus	115-119
11571246-7	2001	Furthermore, the iron deposition as well as tissue iron content was much less in aortic tissue of Adv-HO-1-treated mice.	Iron	17-21	heme oxygenase 1	Mus musculus	102-106
11571246-7	2001	Furthermore, the iron deposition as well as tissue iron content was much less in aortic tissue of Adv-HO-1-treated mice.	Iron	51-55	heme oxygenase 1	Mus musculus	102-106
11571246-9	2001	CONCLUSIONS: Overexpression of HO-1 in vascular cells facilitates iron metabolism and attenuates development of atherosclerosis in apoE-deficient mice.	Iron	66-70	heme oxygenase 1	Mus musculus	31-35
11551197-9	2001	Presented here, the X-ray crystallographic, single-crystal, and solution resonance Raman studies at room temperature confirmed that the sixth coordination position of heme iron of ATP A2 is essentially vacant.	Iron	172-176	peroxidase 2	Arabidopsis thaliana	180-186
11535049-8	2001	Fe(II) forms of MPO and LPO, but not EPO, displayed significantly lower affinity toward NO compared to Fe(III) forms, suggesting that heme reduction causes a dramatic change in the heme pocket electronic environment that alters the affinity and/or accessibility of heme iron toward NO.	Iron	207-211	myeloperoxidase	Homo sapiens	16-19
11535049-8	2001	Fe(II) forms of MPO and LPO, but not EPO, displayed significantly lower affinity toward NO compared to Fe(III) forms, suggesting that heme reduction causes a dramatic change in the heme pocket electronic environment that alters the affinity and/or accessibility of heme iron toward NO.	Iron	207-211	lactoperoxidase	Homo sapiens	24-27
11448968-0	2001	Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast.	Iron	15-19	Aft2p	Saccharomyces cerevisiae S288C	0-5
11448968-10	2001	These results suggest that Aft2p and Aft1p have overlapping roles in the control of iron-regulated pathway(s) connected to oxidative stress resistance in yeast.	Iron	84-88	Aft2p	Saccharomyces cerevisiae S288C	27-32
11448968-0	2001	Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast.	Iron	96-100	Aft2p	Saccharomyces cerevisiae S288C	0-5
11524010-1	2001	The iron-chelating peptide vibriobactin of the pathogenic Vibrio cholerae is assembled by a four-subunit nonribosomal peptide synthetase complex, VibE, VibB, VibH, and VibF, using 2,3-dihydroxybenzoate and L-threonine as precursors to two 2,3-dihydroxyphenyl- (DHP-) methyloxazolinyl groups in amide linkage on a norspermidine scaffold.	Iron	4-8	dihydropyrimidinase	Homo sapiens	261-264
11564086-0	2001	Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.	Iron	58-62	transferrin	Homo sapiens	40-51
11532683-3	2001	Also potentially modulating response to EPO is diurnal variation in the bioavailability of serum iron.	Iron	97-101	erythropoietin	Homo sapiens	40-43
11575828-5	2001	Iron supplements, oral, IV, or both, were administered to maintain percent transferrin saturation (TSAT) at 20-30% and/or a serum ferritin of 100-500 ng/ml.	Iron	0-4	transferrin	Homo sapiens	75-86
11564086-2	2001	Excessive transfusions may lead high non-transferrin-bound iron (NTBI).	Iron	59-63	transferrin	Homo sapiens	41-52
11564645-9	2001	Infusion of the iron chelator deferoxamine (0.2 mM for 180 min) decreased dialysate DA and attenuated SIN-1-induced increases in dialysate DA concentrations.	Iron	16-20	MAPK associated protein 1	Homo sapiens	102-107
11564645-11	2001	These results suggest that iron plays a key role in SIN-1-induced release of striatal DA and do not support any role for either peroxynitrite or superoxide anion in SIN-1-induced release of striatal DA.	Iron	27-31	MAPK associated protein 1	Homo sapiens	52-57
11592595-0	2001	Venesection therapy of insulin resistance-associated hepatic iron overload.	Iron	61-65	insulin	Homo sapiens	23-30
11591199-3	2001	Heme oxygenase-1 (HO-1) protein, also called HSP32, is the rate-limiting enzyme in the catabolism of heme to biliverdin, free iron and CO.	Iron	126-130	heme oxygenase 1	Mus musculus	0-16
11591199-3	2001	Heme oxygenase-1 (HO-1) protein, also called HSP32, is the rate-limiting enzyme in the catabolism of heme to biliverdin, free iron and CO.	Iron	126-130	heme oxygenase 1	Mus musculus	18-22
11591199-3	2001	Heme oxygenase-1 (HO-1) protein, also called HSP32, is the rate-limiting enzyme in the catabolism of heme to biliverdin, free iron and CO.	Iron	126-130	heme oxygenase 1	Mus musculus	45-50
11496057-2	2001	Contrary to the original view, erythropoietin-induced hypertension is not due to amelioration of anemia, because a similar rise in blood pressure occurs, despite persistent anemia, in erythropoietin-treated iron-deficient animals and humans.	Iron	207-211	erythropoietin	Homo sapiens	31-45
11496057-2	2001	Contrary to the original view, erythropoietin-induced hypertension is not due to amelioration of anemia, because a similar rise in blood pressure occurs, despite persistent anemia, in erythropoietin-treated iron-deficient animals and humans.	Iron	207-211	erythropoietin	Homo sapiens	184-198
11500408-2	2001	The virulence of P. aeruginosa PAO1 is influenced by the iron- and oxygen-regulated gene encoding the alternative sigma factor PvdS, which is regulated through the ferric uptake regulator (Fur).	Iron	57-61	ferric uptake regulation protein	Pseudomonas aeruginosa PAO1	189-192
11517734-11	2001	Based on the results from this study we can conclude that substituting organic forms of iron in bovine milk-base infant formulae would have beneficial effects on both the solubility and bioavailability of this important micronutrient.	Iron	88-92	Weaning weight-maternal milk	Bos taurus	103-107
11592595-1	2001	BACKGROUND/AIMS: The association of hepatic iron overload with metabolic disorders has been coined as the insulin resistance-associated hepatic iron overload syndrome (IR-HIO).	Iron	44-48	insulin	Homo sapiens	106-113
11522873-5	2001	iron supplementation was conducted in all Princess Alexandra Hospital PD patients who were on a stable dose of Epo, had no identifiable cause of impaired haemopoiesis other than uraemia, and had normal iron stores (transferrin saturation &gt;20% and serum ferritin 100-500 mg/l).	Iron	0-4	erythropoietin	Homo sapiens	111-114
11535942-6	2001	The transferrin value - estimated as the total iron-binding capacity (TIBC) - was significantly lower in alcoholic cirrhosis of the liver in comparison to both chronic hepatitis C (p&lt;0.004) and chronic hepatitis B (p&lt;0.04).	Iron	47-51	transferrin	Homo sapiens	4-15
11522873-1	2001	BACKGROUND: Concomitant iron supplementation is required in the great majority of erythropoietin (Epo)-treated patients with end-stage renal failure.	Iron	24-28	erythropoietin	Homo sapiens	82-96
11522873-1	2001	BACKGROUND: Concomitant iron supplementation is required in the great majority of erythropoietin (Epo)-treated patients with end-stage renal failure.	Iron	24-28	erythropoietin	Homo sapiens	98-101
11532115-3	2001	We tested the hypothesis that a circulating serum factor [non-parathyroid hormone (non-PTH)], which operates during chronic renal failure (CRF) to maintain phosphate (Pi) homeostasis, can increase fractional excretion of Pi (FE(PO4)) in normal functioning kidney grafts during the early post-transplant period, thereby causing phosphaturia and hypophosphatemia.	Iron	225-227	parathyroid hormone	Homo sapiens	87-90
11532115-16	2001	CONCLUSION: A non-PTH circulating serum factor (possibly phosphatonin) that increases FE(PO4) during CRF is also responsible for phosphaturia and hypophosphatemia in the early period following successful kidney transplantation.	Iron	86-88	parathyroid hormone	Homo sapiens	18-21
11528242-0	2001	Effect of weekly or successive iron supplementation on erythropoietin doses in patients receiving hemodialysis.	Iron	31-35	erythropoietin	Homo sapiens	55-69
11528242-1	2001	AIMS: To conduct a 3-month prospective study to determine the optimal way for intravenous iron supplementation in hemodialysis (HD) patients with resistance to recombinant human erythropoietin (rHuEPO) therapy due to deficient iron storage.	Iron	90-94	erythropoietin	Homo sapiens	178-192
12578598-0	2001	[The Effect of Low Molecular Protein Iron on Iron Deficiency Anemia] Objective is designed to observe the effect of the low molecular protein "SL Hong-Xin Blood-Increasing Capsules" on human iron deficiency anemia.	Iron	37-41	xin actin binding repeat containing 1	Homo sapiens	151-154
11795024-0	2001	[Role of iron treatment in the optimization of the use of erythropoietin (EPO) in hemodialyzed patients].	Iron	9-13	erythropoietin	Homo sapiens	58-72
11795024-0	2001	[Role of iron treatment in the optimization of the use of erythropoietin (EPO) in hemodialyzed patients].	Iron	9-13	erythropoietin	Homo sapiens	74-77
11702419-8	2001	The P50 of the estimated iron mean intakes were 16.2 and 15.2 mg/day for men and women, respectively, and those of vitamin C were 145.1 and 147.5 mg/day, for men and women, respectively.	Iron	25-29	nuclear factor kappa B subunit 1	Homo sapiens	4-7
12578598-0	2001	[The Effect of Low Molecular Protein Iron on Iron Deficiency Anemia] Objective is designed to observe the effect of the low molecular protein "SL Hong-Xin Blood-Increasing Capsules" on human iron deficiency anemia.	Iron	45-49	xin actin binding repeat containing 1	Homo sapiens	151-154
12578598-6	2001	In conclusion the active ingredient of "SL Hong-Xin Blood-Increasing Capsules" is low molecular protein iron, which is markedly effective for elevating Hb content and hematocrit percentage, and effective for decresing protoporphyrin content of children with iron deficiency anemia.	Iron	104-108	xin actin binding repeat containing 1	Homo sapiens	48-51
11390404-8	2001	The sensitivity to iron is exacerbated by ectopic expression of the iron transporter FET4.	Iron	19-23	Fet4p	Saccharomyces cerevisiae S288C	85-89
11583172-0	2001	Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.	Iron	47-51	1-aminocyclopropane-1-carboxylate oxidase	Solanum lycopersicum	70-81
11485568-5	2001	Three of the Type I ligands, S-ethylisothiourea, L-canavanine and 2,5-lutidine, displaced the CO from the haem iron upon addition to the iNOS oxygenase domain.	Iron	111-115	nitric oxide synthase 2, inducible	Mus musculus	137-141
11488074-0	2001	Histologic features of the liver in insulin resistance-associated iron overload.	Iron	66-70	insulin	Homo sapiens	36-43
11488074-2	2001	The aim of the present study was to describe histologic features of the liver in insulin resistance-associated hepatic iron overload (IR-HIO), defined as the association of metabolic disorders and hepatic iron overload.	Iron	119-123	insulin	Homo sapiens	81-88
11488074-2	2001	The aim of the present study was to describe histologic features of the liver in insulin resistance-associated hepatic iron overload (IR-HIO), defined as the association of metabolic disorders and hepatic iron overload.	Iron	205-209	insulin	Homo sapiens	81-88
11513189-1	2001	OBJECTIVE: The aim of this study was to define in patients with hyperferritinemia and normal transferrin saturation the relationships among hyperferritinemia, iron overload, HFE gene mutations, the presence of metabolic alterations, and nonalcoholic steatohepatitis (NASH).	Iron	159-163	transferrin	Homo sapiens	93-104
11513189-11	2001	The simultaneous disorder of iron and glucose and/or lipid metabolism, in most of the cases associated with insulin resistance, is responsible for persistent hyperferritinemia and identifies patients at risk for NASH.	Iron	29-33	insulin	Homo sapiens	108-115
11509470-0	2001	Iron supplementation inhibits cough associated with ACE inhibitors.	Iron	0-4	angiotensin I converting enzyme	Homo sapiens	52-55
11463361-3	2001	The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the iron-chelating agents used, the oxidation state of iron (Fe(2+) or Fe(3+)) and the iron concentration tested.	Iron	26-30	transferrin	Rattus norvegicus	8-19
11463361-8	2001	The rate of transferrin-bound iron uptake was less than 1% of the non-transferrin-bound iron uptake and the maximum transferrin-bound iron uptake was also very low.	Iron	30-34	transferrin	Rattus norvegicus	12-23
11463361-8	2001	The rate of transferrin-bound iron uptake was less than 1% of the non-transferrin-bound iron uptake and the maximum transferrin-bound iron uptake was also very low.	Iron	88-92	transferrin	Rattus norvegicus	12-23
11463361-8	2001	The rate of transferrin-bound iron uptake was less than 1% of the non-transferrin-bound iron uptake and the maximum transferrin-bound iron uptake was also very low.	Iron	88-92	transferrin	Rattus norvegicus	70-81
11463361-8	2001	The rate of transferrin-bound iron uptake was less than 1% of the non-transferrin-bound iron uptake and the maximum transferrin-bound iron uptake was also very low.	Iron	88-92	transferrin	Rattus norvegicus	70-81
11463361-8	2001	The rate of transferrin-bound iron uptake was less than 1% of the non-transferrin-bound iron uptake and the maximum transferrin-bound iron uptake was also very low.	Iron	88-92	transferrin	Rattus norvegicus	12-23
11463361-8	2001	The rate of transferrin-bound iron uptake was less than 1% of the non-transferrin-bound iron uptake and the maximum transferrin-bound iron uptake was also very low.	Iron	88-92	transferrin	Rattus norvegicus	70-81
11463361-8	2001	The rate of transferrin-bound iron uptake was less than 1% of the non-transferrin-bound iron uptake and the maximum transferrin-bound iron uptake was also very low.	Iron	88-92	transferrin	Rattus norvegicus	70-81
11487733-3	2001	Targeting expression of hsp70i to hippocampal neurons protected these cells significantly from toxic levels of glutamate and oxidative stress (for example, exposure to 10 micromol/L free iron produced a 26% increase in lactate dehydrogenase release from neurons cultured from wild-type mice, but a 7% increase in neurons cultured from hsp70i transgenic mice).	Iron	187-191	heat shock protein family A (Hsp70) member 1A	Homo sapiens	24-30
11487733-3	2001	Targeting expression of hsp70i to hippocampal neurons protected these cells significantly from toxic levels of glutamate and oxidative stress (for example, exposure to 10 micromol/L free iron produced a 26% increase in lactate dehydrogenase release from neurons cultured from wild-type mice, but a 7% increase in neurons cultured from hsp70i transgenic mice).	Iron	187-191	heat shock protein family A (Hsp70) member 1A	Homo sapiens	335-341
12530992-4	2001	The amount of free iron is also kept to a minimum thanks to binding to transferrin for transport, and to ferritin for storage.	Iron	19-23	transferrin	Homo sapiens	71-82
11694048-2	2001	The object of this study was to analyse the concentration and distribution of zinc, copper, selenium, manganese and iron in camel milk compared to those in human milk, cows" milk and infant formula under similar experimental conditions.	Iron	116-120	Weaning weight-maternal milk	Bos taurus	130-134
11694048-6	2001	The concentration of manganese and iron in camels" milk was remarkably higher (7-20-fold and 4-10-fold, respectively) than in human milk, cows" milk and infant formula.	Iron	35-39	Weaning weight-maternal milk	Bos taurus	51-55
11448240-6	2001	WTK1 cells (mutant TP53) were more resistant to the cytotoxic effects of both gamma rays and (56)Fe particles, but showed greater cytogenetic and mutagenic damage than TK6 cells (TP53(+)).	Iron	97-99	tumor protein p53	Homo sapiens	19-23
12143465-3	2001	This article presents information that supports the fact that maintenance of TSATs between 30% and 50%, through the use of continuous intravenous iron therapy, results in improvement of anemia, reduction in erythropoietin dose requirements, and an increase in the reticulocyte hemoglobin content.	Iron	146-150	erythropoietin	Homo sapiens	207-221
11313346-2	2001	The translation of many iron proteins is controlled by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem loop structures, known as iron-responsive elements (IREs), found in the untranslated regions of their mRNAs.	Iron	24-28	iron responsive element binding protein 2	Homo sapiens	138-142
11514223-1	2001	The NRAMP family of divalent-metal transporters plays a key role in the homeostasis of iron and other metals.	Iron	87-91	solute carrier family 11 member 1	Homo sapiens	4-9
11313346-2	2001	The translation of many iron proteins is controlled by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem loop structures, known as iron-responsive elements (IREs), found in the untranslated regions of their mRNAs.	Iron	96-100	iron responsive element binding protein 2	Homo sapiens	138-142
11313346-3	2001	In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor).	Iron	15-19	iron responsive element binding protein 2	Homo sapiens	41-45
11313346-3	2001	In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor).	Iron	15-19	aconitase 2	Homo sapiens	171-194
11313346-3	2001	In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor).	Iron	110-114	iron responsive element binding protein 2	Homo sapiens	41-45
11313346-3	2001	In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor).	Iron	110-114	iron responsive element binding protein 2	Homo sapiens	41-45
11404260-5	2001	However, Cu/Zn SOD expression had a marked influence on hepatic copper and iron as well as circulating copper homeostasis.	Iron	75-79	superoxide dismutase 1, soluble	Mus musculus	9-18
11442362-7	2001	These studies are then extended to consider the new features present in the binuclear non-heme iron enzymes and applied to understand (1) the mechanism of the two electron/coupled proton transfer to dioxygen binding to a single iron center in hemerythrin and (2) structure/function correlations over the oxygen-activating enzymes stearoyl-ACP Delta9-desaturase, ribonucleotide reductase, and methane monooxygenase.	Iron	95-99	fatty acid desaturase 3	Homo sapiens	343-360
11442362-7	2001	These studies are then extended to consider the new features present in the binuclear non-heme iron enzymes and applied to understand (1) the mechanism of the two electron/coupled proton transfer to dioxygen binding to a single iron center in hemerythrin and (2) structure/function correlations over the oxygen-activating enzymes stearoyl-ACP Delta9-desaturase, ribonucleotide reductase, and methane monooxygenase.	Iron	228-232	fatty acid desaturase 3	Homo sapiens	343-360
11427068-2	2001	An initial model compound was constructed from a structure obtained by 300-ps molecular dynamics simulation of compound I-formed P-450cam under physiologic conditions, and it consisted of porphine for protoporphyrin IX, S(-)-CH(3) for the side chain of Cys357 of the fifth ligand of heme, a methane molecule for the substrate, a heme iron, and an oxygen atom of the sixth ligand of heme.	Iron	334-338	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-121
11431174-7	2001	In addition, dissociation of iron from filtered transferrin, occasioned by a reduction in tubular fluid pH, can promote tubulointerstitial injury through the iron-catalyzed generation of oxygen free radicals.	Iron	158-162	transferrin	Homo sapiens	48-59
11449359-0	2001	Nramp1 modulates iron homoeostasis in vivo and in vitro: evidence for a role in cellular iron release involving de-acidification of intracellular vesicles.	Iron	17-21	solute carrier family 11 member 1	Homo sapiens	0-6
11449359-0	2001	Nramp1 modulates iron homoeostasis in vivo and in vitro: evidence for a role in cellular iron release involving de-acidification of intracellular vesicles.	Iron	89-93	solute carrier family 11 member 1	Homo sapiens	0-6
11449359-3	2001	We demonstrate Nramp1 is implicated in iron regulation in vivo.	Iron	39-43	solute carrier family 11 member 1	Homo sapiens	15-21
11449359-5	2001	By morphometric analysis, the distribution of splenic iron, following systemic overload, correlates with Nramp1 genotype.	Iron	54-58	solute carrier family 11 member 1	Homo sapiens	105-111
11449359-6	2001	More iron is located within the red pulp in Nramp1(D169) strains, whereas in Nramp1(G169) strains iron deposits are localized within the marginal-zone metallophilic cells.	Iron	5-9	solute carrier family 11 member 1	Homo sapiens	44-50
11424192-10	2001	Because activation of microglia is associated with an increase in iron accumulation and ferritin expression, we tested the hypothesis that iron status affects the production of TNF-alpha and NO.	Iron	139-143	tumor necrosis factor	Rattus norvegicus	177-186
11424192-11	2001	Our studies demonstrate that both iron chelation and iron loading diminished the LPS-induced effect of TNF-alpha and NO.	Iron	34-38	tumor necrosis factor	Rattus norvegicus	103-112
11449359-6	2001	More iron is located within the red pulp in Nramp1(D169) strains, whereas in Nramp1(G169) strains iron deposits are localized within the marginal-zone metallophilic cells.	Iron	98-102	solute carrier family 11 member 1	Homo sapiens	77-83
11424192-11	2001	Our studies demonstrate that both iron chelation and iron loading diminished the LPS-induced effect of TNF-alpha and NO.	Iron	53-57	tumor necrosis factor	Rattus norvegicus	103-112
11449359-8	2001	Nramp1 protein expression demonstrates an inverse correlation to the presence of iron.	Iron	81-85	solute carrier family 11 member 1	Homo sapiens	0-6
11449359-10	2001	In contrast, Nramp1(D169) strains display iron-staining cells.	Iron	42-46	solute carrier family 11 member 1	Homo sapiens	13-19
11449359-11	2001	The process of cellular iron regulation was investigated in vitro in Nramp1(G169) transfectant Raw264.7 macrophages.	Iron	24-28	solute carrier family 11 member 1	Homo sapiens	69-75
11449359-12	2001	Greater (30-50%) iron efflux from Nramp1(G169) compared with Nramp1(D169) cells was determined.	Iron	17-21	solute carrier family 11 member 1	Homo sapiens	34-40
11449359-13	2001	The extent of Nramp1-dependent iron-release was influenced by bafilomycin A1, and endogenous nitric oxide synthesis, both inhibitors of vacuolar-ATPase.	Iron	31-35	solute carrier family 11 member 1	Homo sapiens	14-20
11449359-14	2001	This study demonstrates that Nramp1 regulates macrophage iron handling, and probably facilitates iron release from macrophages undergoing erythrophagocytosis in vivo.	Iron	57-61	solute carrier family 11 member 1	Homo sapiens	29-35
11449359-14	2001	This study demonstrates that Nramp1 regulates macrophage iron handling, and probably facilitates iron release from macrophages undergoing erythrophagocytosis in vivo.	Iron	97-101	solute carrier family 11 member 1	Homo sapiens	29-35
11431434-4	2001	Total ferritin concentration was measured by ELISA: Fe uptake and incorporation into ferritin was determined by incubating transfected cells with (59)Fe-labeled transferrin followed by native PAGE electrophoresis.	Iron	150-152	transferrin	Homo sapiens	161-172
11423579-10	2001	Among patients who received recombinant human erythropoietin, only 47% received iron.	Iron	80-84	erythropoietin	Homo sapiens	46-60
11421626-6	2001	Consideration should be given to have patients evaluated for levels of interferon-gamma and interleukin-4 as well as for serum ferritin and transferrin iron saturation.	Iron	152-156	transferrin	Homo sapiens	140-151
11444611-1	2001	Electrochemical reduction of the iron bound in the heme group of cytochrome c is shown to occur in the nano-electrospray capillary if the protein is sprayed from neutral water using a steel wire as the electrical contact.	Iron	33-37	cytochrome c, somatic	Homo sapiens	65-77
11444611-2	2001	Quadrupole ion trap collisional activation is used to study the dissociation reactions of cytochrome c as a function of the oxidation state of the iron.	Iron	147-151	cytochrome c, somatic	Homo sapiens	90-102
11597031-5	2001	Under iron-limiting conditions, the pathogenic strains of P. gingivalis had a much lower requirement for human iron-loaded transferrin and hemin than the non-pathogenic strains.	Iron	6-10	transferrin	Homo sapiens	123-134
11597031-5	2001	Under iron-limiting conditions, the pathogenic strains of P. gingivalis had a much lower requirement for human iron-loaded transferrin and hemin than the non-pathogenic strains.	Iron	111-115	transferrin	Homo sapiens	123-134
11597031-6	2001	Proteolytic degradation of transferrin, which may be associated with the release of iron, was not markedly different for pathogenic and non-pathogenic strains.	Iron	84-88	transferrin	Homo sapiens	27-38
11985981-3	2001	Iron-containing heme is known to be a cofactor for nitric oxide synthase (NOS), the enzyme responsible for NO production.	Iron	0-4	nitric oxide synthase 2	Homo sapiens	51-72
11985981-12	2001	VIP(10-28) led to greater relaxation in the Fe+ animals (45.8 +/- 6.6%) than in the Fe- animals (23.4 +/- 5.8%; P &lt;0.05).	Iron	44-46	vasoactive intestinal peptide	Homo sapiens	0-3
11422765-0	2001	Diagnostic value of iron indices in hemodialysis patients receiving epoetin.	Iron	20-24	erythropoietin	Homo sapiens	68-75
11422765-8	2001	Two thirds of the patients receiving parenteral iron had a decrease in their epoetin requirement of at least 30 U/kg/week compared with 29% of patients who did not receive iron (P = 0.004).	Iron	48-52	erythropoietin	Homo sapiens	77-84
11422765-11	2001	CONCLUSIONS: Iron deficiency commonly develops during epoetin therapy, and parenteral iron administration may result in a clinically significant reduction in epoetin dose.	Iron	86-90	erythropoietin	Homo sapiens	158-165
11445268-5	2001	On the basis of these findings we advance the hypothesis that expression of ubiquitin, alpha B-crystallin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys represents a stress response possibly related to increased iron-mediated oxidative stress.	Iron	227-231	LOC106995557	Macaca mulatta	76-85
11427634-0	2001	The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin.	Iron	70-74	erythropoietin	Homo sapiens	116-130
11427634-1	2001	BACKGROUND: Iron deficiency (ID) is the main cause of hyporesponsiveness to erythropoietin in haemodialysis patients and its detection is of value since it is easily corrected by intravenous iron.	Iron	191-195	erythropoietin	Homo sapiens	76-90
11427634-9	2001	CONCLUSIONS: In haemodialysis patients on maintenance erythropoietin, Hypo &gt;6% is the best currently available marker to identify those who will improve their response after intravenous iron.	Iron	189-193	erythropoietin	Homo sapiens	54-68
11301321-4	2001	The membrane-permeant, intracellular Fe(2+) chelator, 2,2"-bipyridine (bipyridyl, BIP), is known to sequester iron from this pool.	Iron	110-114	heat shock protein family A (Hsp70) member 5	Homo sapiens	82-85
11452166-1	2001	BACKGROUND: Preoperative treatment with rHuEPO (epoetin alfa: EPREX, Janssen-Cilag; or PROCRIT, Ortho Biotech) in conjunction with iron supplementation increases the erythropoietic response in elective orthopedic surgery patients, but it is not known whether the magnitude of this response is dependent on the route of iron administration.	Iron	319-323	erythropoietin	Homo sapiens	48-55
11443722-1	2001	A quantitative model is proposed for computing the dependence on the interecho time of the NMR relaxation rate in iron-rich gray matter obtained with a Carr-Purcell-Meiboom-Gill sequence.	Iron	114-118	arrestin 3	Homo sapiens	152-156
11301321-10	2001	In parallel with its inhibition of vaccinia RR activation, BIP treatment increased the RNA binding activity of the endogenous iron-response protein, IRP1, by 1.9-fold.	Iron	126-130	heat shock protein family A (Hsp70) member 5	Homo sapiens	59-62
11301321-11	2001	The data indicate that the diiron prosthetic group in vaccinia RR is assembled from iron taken from the BIP-accessible, labile iron pool that is sampled also by ferritin and the iron-regulated protein found in the cytosol of mammalian cells.	Iron	29-33	heat shock protein family A (Hsp70) member 5	Homo sapiens	104-107
11301321-11	2001	The data indicate that the diiron prosthetic group in vaccinia RR is assembled from iron taken from the BIP-accessible, labile iron pool that is sampled also by ferritin and the iron-regulated protein found in the cytosol of mammalian cells.	Iron	84-88	heat shock protein family A (Hsp70) member 5	Homo sapiens	104-107
11389698-8	2001	Iron efflux is thought to be mediated by the metal transporter protein, IREG1/ferroportin1/MTP1, and oxidation of Fe(II) to Fe(III) prior to incorporation into fetal transferrin is carried out by the placental copper oxidase.	Iron	0-4	transferrin	Homo sapiens	166-177
11389698-10	2001	In BeWo cells made iron deficient by treatment with desferrioxamine ("deferioxamine"), iron accumulation from iron-transferrin increased, in parallel with increased expression of the transferrin receptor.	Iron	19-23	transferrin	Homo sapiens	115-126
11389698-10	2001	In BeWo cells made iron deficient by treatment with desferrioxamine ("deferioxamine"), iron accumulation from iron-transferrin increased, in parallel with increased expression of the transferrin receptor.	Iron	87-91	transferrin	Homo sapiens	115-126
11457377-9	2001	Interestingly, when supercoiled plasmid DNA was used as a substrate, conjugated Fe.BLM A(5) and Co.BLM A(5) were both found to produce Form III DNA in addition to Form II DNA.	Iron	80-82	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	140-143
11404470-9	2001	These studies suggest that phenserine reduces Abeta levels by regulating betaAPP translation via the recently described iron regulatory element in the 5"-untranslated region of betaAPP mRNA, which has been shown previously to be up-regulated in the presence of interleukin-1.	Iron	120-124	amyloid beta precursor protein	Homo sapiens	46-51
11406113-0	2001	Iron-induced oxidative damage of corn root plasma membrane H(+)-ATPase.	Iron	0-4	membrane H(+)-ATPase 1	Zea mays	43-70
11406113-1	2001	The effect of iron on the activity of the plasma membrane H(+)-ATPase (PMA) from corn root microsomal fraction (CRMF) was investigated.	Iron	14-18	membrane H(+)-ATPase 1	Zea mays	42-69
11406113-1	2001	The effect of iron on the activity of the plasma membrane H(+)-ATPase (PMA) from corn root microsomal fraction (CRMF) was investigated.	Iron	14-18	membrane H(+)-ATPase 1	Zea mays	71-74
11406113-11	2001	These results indicate that iron causes irreversible inhibition of the corn root plasma membrane H(+)-ATPase by oxidation of sulfhydryl groups of the enzyme following lipid peroxidation.	Iron	28-32	membrane H(+)-ATPase 1	Zea mays	81-108
11457377-10	2001	The formation of Form III DNA by conjugated Fe.BLM A(5) was assessed quantitatively.	Iron	44-46	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	22-25
11457377-11	2001	When corrected for differences in the intrinsic efficiencies of DNA cleavage by conjugated vs free BLMs, conjugated Fe.BLM A(5) was found to produce Form III DNA to about the same extent as the respective free Fe.BLM A(5), arguing that this conjugated BLM can also effect double-strand cleavage of DNA.	Iron	116-118	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	154-157
11503575-7	2001	An inverse correlation between the IL-6 levels and both, the hemoglobin concentration and the serum iron was found, and there was a direct correlation between this cytokine values and the EPO levels.	Iron	100-104	interleukin 6	Homo sapiens	35-39
11403301-0	2001	Dynamics of iron release from transferrin N-lobe studied by electrospray ionization mass spectrometry.	Iron	12-16	transferrin	Homo sapiens	30-41
11380478-0	2001	Non-transferrin-bound iron during allogeneic stem cell transplantation.	Iron	22-26	transferrin	Homo sapiens	4-15
11368756-2	2001	Repression of the heavy ferritin subunit evoked an increase in the chemical levels and pro-oxidant activity of the labile iron pool and, in turn, caused a reduced expression of transferrin receptors and increased expression of the light ferritin subunit.	Iron	122-126	transferrin	Homo sapiens	177-188
11380478-1	2001	Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications.	Iron	62-66	transferrin	Homo sapiens	44-55
11472024-3	2001	In vivo studies with rats have shown that the iron transport protein transferrin serves as the major chromic ion transport agent and that this transport is stimulated by insulin.	Iron	46-50	transferrin	Rattus norvegicus	69-80
11262412-3	2001	1) In the presence of myxothiazol, MOA-stilbene, stigmatellin, or of antimycin added to SMP pretreated with ascorbate and KCN to reduce the high potential components (iron-sulfur protein (ISP) and cytochrome c(1)) of complex III, addition of succinate reduced heme b(H) followed by a slow and partial reduction of heme b(L).	Iron	167-171	cytochrome c1	Bos taurus	197-212
11475112-1	2001	In the present study we examined the effect of recombinant human erythropoietin (rhEPO) on intestinal malondialdehyde (MDA) as an index of lipid peroxidation, related to iron-catalysed free radical reaction and platelet-activating factor (PAF) synthesis in the experimental model of necrotizing enterocolitis (NEC).	Iron	170-174	erythropoietin	Homo sapiens	65-79
11389189-6	2001	IFN-beta decreased HO-1 expression and mitochondrial iron sequestration in IL-1beta- and TNF-alpha-challenged astroglia.	Iron	53-57	interleukin 1 beta	Homo sapiens	75-83
11410240-2	2001	The SOD activity of 5,10,15,20-tetrakis(4-N-methylpyridyl)]porphine (MPy(4)P) containing Fe, Mn or Cu was measured using a cytochrome c assay by the xanthine/xanthine oxidase system and stopped-flow kinetic analysis.	Iron	89-91	superoxide dismutase 1	Homo sapiens	4-7
11439314-6	2001	Insulin sensitivity (M-value) was correlated with PRA before euglycaemic hyperinsulinaemic clamping (r = 0.577, P &lt; 0.05), and was also inversely correlated with fractional excretion of sodium (FE(Na)) before clamping (r = -0.51, P &lt; 0.05).	Iron	197-199	insulin	Homo sapiens	0-7
11389189-6	2001	IFN-beta decreased HO-1 expression and mitochondrial iron sequestration in IL-1beta- and TNF-alpha-challenged astroglia.	Iron	53-57	tumor necrosis factor	Homo sapiens	89-98
11413227-3	2001	The fact that the four-line spectrum obtained for the Abeta/PBN in PBS was completely abolished in the presence of the iron-chelating agent Desferal demonstrated the observed four-line spectrum to be iron-dependent.	Iron	119-123	amyloid beta precursor protein	Homo sapiens	54-59
11533837-0	2001	The role of high-dose oral iron supplementation during erythropoietin therapy for anemia of prematurity.	Iron	27-31	erythropoietin	Homo sapiens	55-69
11413227-3	2001	The fact that the four-line spectrum obtained for the Abeta/PBN in PBS was completely abolished in the presence of the iron-chelating agent Desferal demonstrated the observed four-line spectrum to be iron-dependent.	Iron	200-204	amyloid beta precursor protein	Homo sapiens	54-59
11533837-1	2001	OBJECTIVE: To assess whether a high intake of oral iron would increase the effect of recombinant human erythropoietin (rHuEPO) on hemoglobin synthesis.	Iron	51-55	erythropoietin	Homo sapiens	103-117
12143456-2	2001	The successful management of these patients entails repletion of iron stores, often through use of intravenous iron, particularly in patients receiving erythropoietin therapy.	Iron	111-115	erythropoietin	Homo sapiens	152-166
11485167-6	2001	Also, it was an attractive hypothesis to suggest that HNE may disrupt the active site by forming a Michael adduct with one or more of the three histidines that ligate the iron active site of LOX-1.	Iron	171-175	seed linoleate 13S-lipoxygenase-1	Glycine max	191-196
11590897-12	2001	High CRP group has more increased level of ERI (p &lt; 0.05), age (p &lt; 0.05) and serum creatinine level (p &lt; 0.05) than normal control, but more decreased level of serum albumin (p &lt; 0.01) and serum iron levels (p &lt; 0.05).	Iron	208-212	C-reactive protein	Homo sapiens	5-8
11337833-6	2001	For conditions with 0.048% Pd/Fe, the rate constants are 0.0215, 0.0155 and 0.0112 min-1 for o-, m-, p-chlorophenol, respectively.	Iron	30-32	CD59 molecule (CD59 blood group)	Homo sapiens	83-88
11325539-0	2001	Effects of sialic acid residues of transferrin on the binding with aluminum and iron studied by HPLC/high-resolution ICP-MS. Transferrins (Tfs) are glycoproteins with carbohydrate chains in the C-lobe.	Iron	80-84	transferrin	Homo sapiens	35-46
11385565-0	2001	High critical currents in iron-clad superconducting MgB2 wires.	Iron	26-30	secretoglobin family 2A member 1	Homo sapiens	52-56
11385565-6	2001	Here we report the successful fabrication of dense, metal-clad superconducting MgB2 wires, and demonstrate a transport Jc in excess of 85,000 A cm-2 at 4.2 K. Our iron-clad fabrication technique takes place at ambient pressure, yet produces dense MgB2 with little loss of stoichiometry.	Iron	163-167	secretoglobin family 2A member 1	Homo sapiens	79-83
11385565-6	2001	Here we report the successful fabrication of dense, metal-clad superconducting MgB2 wires, and demonstrate a transport Jc in excess of 85,000 A cm-2 at 4.2 K. Our iron-clad fabrication technique takes place at ambient pressure, yet produces dense MgB2 with little loss of stoichiometry.	Iron	163-167	secretoglobin family 2A member 1	Homo sapiens	247-251
11278728-2	2001	We have previously isolated yeast mutants of the mitochondrial Hsp70, Ssq1p, in a genetic screen for mutants with altered iron homeostasis.	Iron	122-126	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	70-75
11278728-11	2001	Similar mitochondrial localization and similar mutant phenotypes suggest that Ssq1p and Jac1p are functional partners in iron homeostasis.	Iron	121-125	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	78-83
11352890-5	2001	Increased release of AA in iron-overloaded NRVMs was reduced by the diacylglycerol lipase inhibitor RHC80267 but was largely insensitive to inhibitors of phospholipases A(2) and C. Iron-overloaded cardiomyocytes also displayed increased production of eicosanoids and induction of cyclooxygenase-2 after stimulation with interleukin-1alpha.	Iron	27-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	280-296
11371199-3	2001	In this study, electron paramagnetic resonance (EPR) spectroscopy was used to investigate the active site iron of purified recombinant human 5-lipoxygenase (5LO), and to explore the action of selenide on 5LO.	Iron	106-110	arachidonate 5-lipoxygenase	Homo sapiens	141-155
11371199-3	2001	In this study, electron paramagnetic resonance (EPR) spectroscopy was used to investigate the active site iron of purified recombinant human 5-lipoxygenase (5LO), and to explore the action of selenide on 5LO.	Iron	106-110	arachidonate 5-lipoxygenase	Homo sapiens	157-160
11320046-0	2001	Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants.	Iron	68-72	transferrin	Homo sapiens	50-61
11427792-6	2001	Iron status was determined from transferrin saturation, serum iron, and serum ferritin.	Iron	0-4	transferrin	Homo sapiens	32-43
11427792-9	2001	Comparison between porphyria cutanea tarda with and without mutations showed that compound C282Y/H63D heterozygous status was significantly linked to iron overload: transferrin saturation=0.61 vs 0.39 (p=0.0001) and serum iron=32.9 vs 22.4 (p=0.0046).	Iron	150-154	transferrin	Homo sapiens	165-176
11427792-11	2001	The class with high iron overload (transferrin saturation &gt; 0.45) was not linked with triggering factors of porphyria cutanea tarda.	Iron	20-24	transferrin	Homo sapiens	35-46
11320046-2	2001	AIM: To investigate the level of non-transferrin bound "free" iron, which has the potential to promote the generation of reactive oxygen species, and its redox status in the plasma of preterm infants immediately before and after blood transfusion.	Iron	62-66	transferrin	Homo sapiens	37-48
11320046-11	2001	CONCLUSIONS: Plasma non-transferrin bound iron was significantly increased in preterm infants after blood transfusion and existed partly in the ferrous form, because of the low ferroxidase activity and the reduction of ferric iron (Fe(3+)) by ascorbic acid.	Iron	42-46	transferrin	Homo sapiens	24-35
11320046-13	2001	Non-transferrin bound "free" iron may catalyse the generation of reactive oxygen species, which may be responsible for the clinical association of blood transfusion with ROP and CLD.	Iron	29-33	transferrin	Homo sapiens	4-15
11313265-8	2001	Surprisingly, Tf-independent iron uptake was also significantly greater in C282Y cells than in WT cells.	Iron	29-33	transferrin	Homo sapiens	14-16
11313265-11	2001	Our results indicate that in this B-lymphoid cell line, the HFE C282Y mutation affects both Tf-dependent and -independent iron uptake and enhances cell sensitivity to oxidative stress.	Iron	122-126	transferrin	Homo sapiens	92-94
11759218-19	2001	Intravenous iron administration has priority upon oral; target levels are 400-800 for ferritin um/ml and &gt; 20 for transferrin saturation.	Iron	12-16	transferrin	Homo sapiens	117-128
11400732-6	2001	An affinity-isolation procedure allowed the isolation of two putative Tf-binding polypeptides (78 and 66 kDa) from total membranes of strains 9L and 642A grown under iron-restricted conditions, and from membranes of all strains if the growth medium also contained Tf.	Iron	166-170	serotransferrin	Bos taurus	70-72
11400732-7	2001	It is concluded that all strains tested acquire Tf-bound iron by means of siderophore-independent mechanisms involving surface receptors analogous to the Tf-binding proteins (TbpA and TbpB) found in comparable organisms; although iron restriction alone is sufficient to promote the expression of these proteins by strains 9L and 642A, their production by strains 714, 5688T, and 3384Y appears to require two signals, iron restriction and the presence of Tf.	Iron	57-61	serotransferrin	Bos taurus	48-50
11400732-7	2001	It is concluded that all strains tested acquire Tf-bound iron by means of siderophore-independent mechanisms involving surface receptors analogous to the Tf-binding proteins (TbpA and TbpB) found in comparable organisms; although iron restriction alone is sufficient to promote the expression of these proteins by strains 9L and 642A, their production by strains 714, 5688T, and 3384Y appears to require two signals, iron restriction and the presence of Tf.	Iron	57-61	serotransferrin	Bos taurus	154-156
11316735-4	2001	In response to FSH, the Sertoli cells express a large number of differentiated gene products, such as transferrin, which transports iron to the developing germ cells.	Iron	132-136	transferrin	Homo sapiens	102-113
11329530-5	2001	A role for iron-catalyzed ROS was suggested by the finding that asbestos-induced AEC apoptosis and caspase 3 activation were each attenuated by either an iron chelator (phytic acid and deferoxamine) or a.OH scavenger (dimethyl-thiourea, salicylate, and sodium benzoate) but not by iron-loaded phytic acid.	Iron	154-158	caspase 3	Homo sapiens	99-108
11329530-9	2001	We conclude that asbestos-induced pulmonary toxicity may partly be caused by apoptosis in the lung epithelium that is mediated by iron-catalyzed ROS and caspase 3 activation.	Iron	130-134	caspase 3	Homo sapiens	153-162
12521853-5	2001	Soluble transferrin receptor assay (STfR) may be useful in these situations because it reflects the degree of iron requirement in relation to supply, and it is not an acute phase reactant.	Iron	110-114	transferrin	Homo sapiens	8-19
11329530-5	2001	A role for iron-catalyzed ROS was suggested by the finding that asbestos-induced AEC apoptosis and caspase 3 activation were each attenuated by either an iron chelator (phytic acid and deferoxamine) or a.OH scavenger (dimethyl-thiourea, salicylate, and sodium benzoate) but not by iron-loaded phytic acid.	Iron	11-15	caspase 3	Homo sapiens	99-108
11329530-5	2001	A role for iron-catalyzed ROS was suggested by the finding that asbestos-induced AEC apoptosis and caspase 3 activation were each attenuated by either an iron chelator (phytic acid and deferoxamine) or a.OH scavenger (dimethyl-thiourea, salicylate, and sodium benzoate) but not by iron-loaded phytic acid.	Iron	154-158	caspase 3	Homo sapiens	99-108
11382547-0	2001	Dephosphorylation of sodium caseinate, enzymatically hydrolyzed casein and casein phosphopeptides by intestinal alkaline phosphatase: implications for iron availability.	Iron	151-155	alkaline phosphatase, intestinal	Homo sapiens	101-132
11382547-6	2001	Hydrolysis of the phospho-ester linkage in phosphoserine residues in casein by IAP releases bound iron or inhibits iron chelation, thereby allowing its absorption.	Iron	98-102	alkaline phosphatase, intestinal	Homo sapiens	79-82
11382547-6	2001	Hydrolysis of the phospho-ester linkage in phosphoserine residues in casein by IAP releases bound iron or inhibits iron chelation, thereby allowing its absorption.	Iron	115-119	alkaline phosphatase, intestinal	Homo sapiens	79-82
11328902-0	2001	A randomized study of oral vs intravenous iron supplementation in patients with progressive renal insufficiency treated with erythropoietin.	Iron	42-46	erythropoietin	Homo sapiens	125-139
11359564-3	2001	We have identified two Streptococcus pneumoniae genetic loci, pit1 and pit2, encoding homologues of ABC iron transporters that are required for iron uptake by this organism.	Iron	104-108	POU domain, class 1, transcription factor 1	Mus musculus	62-66
11328924-0	2001	Intravenous administration of iron in epoetin-treated haemodialysis patients.	Iron	30-34	erythropoietin	Homo sapiens	38-45
11475345-15	2001	CONCLUSION: Our study indicates that IV iron in PD patients is effective in restoring iron stores and in decreasing EPO requirements.	Iron	40-44	erythropoietin	Homo sapiens	116-119
11335103-0	2001	Iron and gallium increase iron uptake from transferrin by human melanoma cells: further examination of the ferric ammonium citrate-activated iron uptake process.	Iron	0-4	transferrin	Homo sapiens	43-54
11335103-0	2001	Iron and gallium increase iron uptake from transferrin by human melanoma cells: further examination of the ferric ammonium citrate-activated iron uptake process.	Iron	26-30	transferrin	Homo sapiens	43-54
11335103-1	2001	Previously we showed that preincubation of cells with ferric ammonium citrate (FAC) resulted in a marked increase in Fe uptake from both (59)Fe-transferrin (Tf) and (59)Fe-citrate (D.R.	Iron	117-119	transferrin	Homo sapiens	144-155
11335103-8	2001	This Fe uptake process was independent of the transferrin receptor and appeared to be activated by free radicals generated via the iron-catalysed Haber-Weiss reaction.	Iron	5-7	transferrin	Homo sapiens	46-57
11336795-6	2001	Uptake of transferrin-iron in wild-type, C282Y and control cells was measured over 45 min.	Iron	22-26	transferrin	Homo sapiens	10-21
11336795-7	2001	The Hill coefficients for transferrin-iron uptake were similar.	Iron	38-42	transferrin	Homo sapiens	26-37
11336795-8	2001	The V(max) for transferrin-iron uptake in wild-type cells was 59.5% of control cells and 69.5% of C282Y cells.	Iron	27-31	transferrin	Homo sapiens	15-26
11336795-11	2001	The results show that HFE reduces transferrin-iron uptake, probably as an uncompetitive inhibitor.	Iron	46-50	transferrin	Homo sapiens	34-45
11329505-1	2001	BACKGROUND: Previous studies have shown that addition of ethanol, iron, or arachidonic acid to HepG2 cells expressing CYP2E1 produced a loss in cell viability and caused apoptosis.	Iron	66-70	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	118-124
11374225-0	2001	[Clinical and economic significance of iron replacement in anemia treated with recombinant human erythropoietin in patients on hemodialysis].	Iron	39-43	erythropoietin	Homo sapiens	97-111
11457014-4	2001	The radical intermediates exist in two electromers that differ in the oxidation state of iron; Por(+)(*)Fe(III)OCH(2)CH(2)(*) and PorFe(IV)OCH(2)CH(2)(*) (Por = porphyrin).	Iron	89-93	cytochrome p450 oxidoreductase	Homo sapiens	95-98
11306436-4	2001	Iron loading also increased gene expression of platelet-derived growth factor (PDGF)-A and transforming growth factor (TGF)-beta(1).	Iron	0-4	transforming growth factor, beta 1	Rattus norvegicus	91-131
11273875-8	2001	Increments in oxidative stress induced by Fe were more pronounced at the end of the administration: MDA, baseline, 0.74 +/- 0.09 nmol/mL; 1 hour, 1.50 +/- 0.28 nmol/mL (P: &lt; 0.001); GSH, baseline, 2.51 +/- 0.34 nmol/mg of hemoglobin (Hb); 1 hour, 1.66 +/- 0.01 nmol/mg Hb (P: &lt; 0.001); and CAT activity, baseline, 27.0 +/- 5.7 kappa/mg Hb; 1 hour, 23.3 +/- 4.2 kappa/mg Hb (P: &lt; 0.001).	Iron	42-44	catalase	Homo sapiens	296-299
11306436-6	2001	The AOS scavenger tetramethylthiourea or treatment of fibers with the iron chelator deferoxamine prevented asbestos-induced increases in procollagen, PDGF-A, and TGF-beta gene expression, whereas glutathione had no effect.	Iron	70-74	transforming growth factor, beta 1	Rattus norvegicus	162-170
11306436-9	2001	Surface iron and AOS also play a role in PDGF-A and TGF-beta gene expression, but through an ERK-dependent mechanism.	Iron	8-12	transforming growth factor, beta 1	Rattus norvegicus	52-60
11306436-9	2001	Surface iron and AOS also play a role in PDGF-A and TGF-beta gene expression, but through an ERK-dependent mechanism.	Iron	8-12	Eph receptor B1	Rattus norvegicus	93-96
11883122-1	2001	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Iron	44-48	transferrin	Homo sapiens	66-77
11348091-10	2001	The presence of both reducing species (Fe0 and Fe2+) and an oxidizing species (MnO2) in Peerless Fe0 is probably responsible for the coexistence of both As(V) and As(III) on Fe0 surfaces.	Iron	39-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	153-158
11348091-10	2001	The presence of both reducing species (Fe0 and Fe2+) and an oxidizing species (MnO2) in Peerless Fe0 is probably responsible for the coexistence of both As(V) and As(III) on Fe0 surfaces.	Iron	97-100	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	153-158
11883122-1	2001	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Iron	44-48	transferrin	Homo sapiens	79-81
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Iron	25-29	cyclin dependent kinase inhibitor 1A	Homo sapiens	149-152
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Iron	25-29	cyclin dependent kinase inhibitor 1A	Homo sapiens	153-157
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Iron	25-29	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-162
11297622-4	2001	Tf bound IGFBP-3 but had negligible affinity to the other five IGFBPs, and iron-saturated holo-Tf bound IGFBP-3 more avidly than unsaturated Tf.	Iron	75-79	transferrin	Homo sapiens	95-97
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Iron	111-115	cyclin dependent kinase inhibitor 1A	Homo sapiens	149-152
11297622-4	2001	Tf bound IGFBP-3 but had negligible affinity to the other five IGFBPs, and iron-saturated holo-Tf bound IGFBP-3 more avidly than unsaturated Tf.	Iron	75-79	transferrin	Homo sapiens	95-97
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Iron	111-115	cyclin dependent kinase inhibitor 1A	Homo sapiens	153-157
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Iron	111-115	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-162
11241357-7	2001	p21(WAF1/CIP1) antisense oligonucleotides caused cell cycle alterations similar to DF and p21 overexpression overcame effects of iron deprivation on both cell cycling and differentiation.	Iron	129-133	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
11241357-7	2001	p21(WAF1/CIP1) antisense oligonucleotides caused cell cycle alterations similar to DF and p21 overexpression overcame effects of iron deprivation on both cell cycling and differentiation.	Iron	129-133	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8
11241357-8	2001	Therefore, p21 is a key target for the effects of iron deprivation on HL-60 cell cycling and differentiation.	Iron	50-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	11-14
11241357-9	2001	Nuclear run-on transcription assays and p21 mRNA half-life studies indicated that iron was required to support transcriptional activation of p21(WAF1/CIP1) after a PMA stimulus.	Iron	82-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	40-43
11241357-9	2001	Nuclear run-on transcription assays and p21 mRNA half-life studies indicated that iron was required to support transcriptional activation of p21(WAF1/CIP1) after a PMA stimulus.	Iron	82-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-144
11241357-9	2001	Nuclear run-on transcription assays and p21 mRNA half-life studies indicated that iron was required to support transcriptional activation of p21(WAF1/CIP1) after a PMA stimulus.	Iron	82-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	145-149
11241357-9	2001	Nuclear run-on transcription assays and p21 mRNA half-life studies indicated that iron was required to support transcriptional activation of p21(WAF1/CIP1) after a PMA stimulus.	Iron	82-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-154
11241357-12	2001	A key role of iron is to allow induction of p21(WAF1/CIP1) in response to a differentiation stimulus subsequently blocking cells at the G(1)/S cell cycle interface and preventing premature apoptosis.	Iron	14-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-47
11354283-6	2001	Tumor necrosis factor-alpha mRNA and protein levels were reduced by 40 and 60%, respectively, in iron-loaded cells compared with controls following the addition of lipopolysaccharide.	Iron	97-101	tumor necrosis factor	Rattus norvegicus	0-27
11354283-7	2001	Interleukin-6 mRNA levels in iron-loaded Kupffer cells were also reduced.	Iron	29-33	interleukin 6	Rattus norvegicus	0-13
11241357-12	2001	A key role of iron is to allow induction of p21(WAF1/CIP1) in response to a differentiation stimulus subsequently blocking cells at the G(1)/S cell cycle interface and preventing premature apoptosis.	Iron	14-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	48-52
11241357-12	2001	A key role of iron is to allow induction of p21(WAF1/CIP1) in response to a differentiation stimulus subsequently blocking cells at the G(1)/S cell cycle interface and preventing premature apoptosis.	Iron	14-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-57
11241357-14	2001	Because of the central role of p21(WAF1/CIP1) as regulator of the G(1)/S cell cycle checkpoint this requirement for iron to support p21 expression represents an important mechanism by which iron may modulate hematopoietic cell growth and differentiation.	Iron	116-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-34
11241357-14	2001	Because of the central role of p21(WAF1/CIP1) as regulator of the G(1)/S cell cycle checkpoint this requirement for iron to support p21 expression represents an important mechanism by which iron may modulate hematopoietic cell growth and differentiation.	Iron	116-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	40-44
11241357-14	2001	Because of the central role of p21(WAF1/CIP1) as regulator of the G(1)/S cell cycle checkpoint this requirement for iron to support p21 expression represents an important mechanism by which iron may modulate hematopoietic cell growth and differentiation.	Iron	116-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-135
11241357-14	2001	Because of the central role of p21(WAF1/CIP1) as regulator of the G(1)/S cell cycle checkpoint this requirement for iron to support p21 expression represents an important mechanism by which iron may modulate hematopoietic cell growth and differentiation.	Iron	190-194	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-34
11374593-0	2001	Effect of bezafibrate and clofibrate on the heme-iron geometry of ferrous nitrosylated heme-human serum albumin: an EPR study.	Iron	49-53	albumin	Homo sapiens	98-111
11241357-14	2001	Because of the central role of p21(WAF1/CIP1) as regulator of the G(1)/S cell cycle checkpoint this requirement for iron to support p21 expression represents an important mechanism by which iron may modulate hematopoietic cell growth and differentiation.	Iron	190-194	cyclin dependent kinase inhibitor 1A	Homo sapiens	35-39
11241357-14	2001	Because of the central role of p21(WAF1/CIP1) as regulator of the G(1)/S cell cycle checkpoint this requirement for iron to support p21 expression represents an important mechanism by which iron may modulate hematopoietic cell growth and differentiation.	Iron	190-194	cyclin dependent kinase inhibitor 1A	Homo sapiens	40-44
11241357-14	2001	Because of the central role of p21(WAF1/CIP1) as regulator of the G(1)/S cell cycle checkpoint this requirement for iron to support p21 expression represents an important mechanism by which iron may modulate hematopoietic cell growth and differentiation.	Iron	190-194	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-135
11240860-5	2001	Incubating transferrin with P. gingivalis resulted in degradation of the protein, a step that may be critical for the acquisition of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	143-154
11318978-9	2001	TGF-beta1 protein was expressed in iron-loaded cells in non-tumour liver at the interface of tumour capsule.	Iron	35-39	transforming growth factor beta 1	Homo sapiens	0-9
11318978-13	2001	The production of TGF-beta1 by iron-loaded hepatic cells at the tumour capsule interface may perpetuate the myofibroblastic phenotype, resulting in the formation of the tumour capsule.	Iron	31-35	transforming growth factor beta 1	Homo sapiens	18-27
11240860-0	2001	Acquisition of iron from human transferrin by Porphyromonas gingivalis: a role for Arg- and Lys-gingipain activities.	Iron	15-19	transferrin	Homo sapiens	31-42
11240860-9	2001	The fact that growth of mutant KDP112 was associated with a lower final optical density and a generation time much longer compared with the parent strain suggests that the Arg-gingipain activity also participates in the acquisition of iron from transferrin.	Iron	235-239	transferrin	Homo sapiens	245-256
11240860-2	2001	The aim of this study was to evaluate the participation of Arg- and Lys-gingipain activities of P. gingivalis in the acquisition of iron from human transferrin and its subsequent utilization in growth.	Iron	132-136	transferrin	Homo sapiens	148-159
11240860-3	2001	Iron-saturated transferrin was found to support the long-term growth of P. gingivalis.	Iron	0-4	transferrin	Homo sapiens	15-26
11240860-11	2001	All three inhibitors were found to completely inhibit growth of strain ATCC 33277 in a medium supplemented with transferrin as the source of iron.	Iron	141-145	transferrin	Homo sapiens	112-123
11240860-5	2001	Incubating transferrin with P. gingivalis resulted in degradation of the protein, a step that may be critical for the acquisition of iron from transferrin.	Iron	133-137	transferrin	Homo sapiens	11-22
11240860-13	2001	The ability of P. gingivalis to cleave transferrin may be an important mechanism for the acquisition of iron from this protein during periodontitis.	Iron	104-108	transferrin	Homo sapiens	39-50
11389759-4	2001	IRT2 expression in yeast suppresses the growth defect of iron and zinc transport yeast mutants and enhances iron uptake and accumulation.	Iron	57-61	iron regulated transporter 2	Arabidopsis thaliana	0-4
11389759-4	2001	IRT2 expression in yeast suppresses the growth defect of iron and zinc transport yeast mutants and enhances iron uptake and accumulation.	Iron	108-112	iron regulated transporter 2	Arabidopsis thaliana	0-4
11389759-8	2001	Altogether, these data support a role for the IRT2 transporter in iron and zinc uptake from the soil in response to iron-limited conditions.	Iron	66-70	iron regulated transporter 2	Arabidopsis thaliana	46-50
11421276-0	2001	ABC transporter-mediated uptake of iron, siderophores, heme and vitamin B12.	Iron	35-39	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	72-75
11389759-8	2001	Altogether, these data support a role for the IRT2 transporter in iron and zinc uptake from the soil in response to iron-limited conditions.	Iron	116-120	iron regulated transporter 2	Arabidopsis thaliana	46-50
11421276-2	2001	Based on experimental studies and sequence analysis data, this article gives a short overview of ABC transporters related to iron uptake: components of three distinct families mediate the translocation of iron, siderophores, heme and vitamin B12 across the cytoplasmic membrane of bacteria.	Iron	125-129	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	242-245
11120744-4	2001	The yeast genome contains five additional FRE1 and FRE2 homologues, four of which are regulated by iron and the major iron-dependent transcription factor, Aft1p, but whose function remains unknown.	Iron	99-103	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	42-46
11421276-2	2001	Based on experimental studies and sequence analysis data, this article gives a short overview of ABC transporters related to iron uptake: components of three distinct families mediate the translocation of iron, siderophores, heme and vitamin B12 across the cytoplasmic membrane of bacteria.	Iron	205-209	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	242-245
11120744-8	2001	Fre4p could facilitate utilization of rhodotorulic acid-iron when the siderophore was present in higher concentrations.	Iron	56-60	ferric-chelate reductase	Saccharomyces cerevisiae S288C	0-5
11120744-9	2001	We propose that Fre3p and Fre4p are siderophore-iron reductases and that the apparent redundancy of the FRE genes confers the capacity to utilize iron from a variety of siderophore sources.	Iron	48-52	ferric-chelate reductase	Saccharomyces cerevisiae S288C	26-31
11395845-9	2001	Administration of recombinant human erythropoietin (r-HuEPO, epoetin alfa) can not only correct inadequate endogenous erythropoietin production, but also can overcome the suppression of erythroid progenitor cells and impairment of iron mobilization.	Iron	231-235	erythropoietin	Homo sapiens	36-50
11395845-9	2001	Administration of recombinant human erythropoietin (r-HuEPO, epoetin alfa) can not only correct inadequate endogenous erythropoietin production, but also can overcome the suppression of erythroid progenitor cells and impairment of iron mobilization.	Iron	231-235	erythropoietin	Homo sapiens	61-68
11120744-4	2001	The yeast genome contains five additional FRE1 and FRE2 homologues, four of which are regulated by iron and the major iron-dependent transcription factor, Aft1p, but whose function remains unknown.	Iron	118-122	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	42-46
11273703-6	2001	Mutants in Ssq1 were reported to have low levels of iron sulfur (FeS) cluster-containing enzymes.	Iron	65-68	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	11-15
11267776-0	2001	Dependence of Staphylococcus epidermidis on non-transferrin-bound iron for growth.	Iron	66-70	transferrin	Homo sapiens	48-59
11110795-1	2001	Saccharomyces cerevisiae Nfs1p is mainly found in the mitochondrial matrix and has been shown to participate in iron-sulfur cluster assembly.	Iron	112-116	cysteine desulfurase	Saccharomyces cerevisiae S288C	25-30
11267776-2	2001	At initial bacterial densities up to 10(4) cfu ml(-1), none of the three strains grew when transferrin iron saturation was below the full saturation point, whereas the bacteria grew consistently when transferrin was fully iron-saturated and there was non-transferrin-bound iron in the medium.	Iron	222-226	transferrin	Homo sapiens	200-211
11267776-2	2001	At initial bacterial densities up to 10(4) cfu ml(-1), none of the three strains grew when transferrin iron saturation was below the full saturation point, whereas the bacteria grew consistently when transferrin was fully iron-saturated and there was non-transferrin-bound iron in the medium.	Iron	222-226	transferrin	Homo sapiens	200-211
11267776-2	2001	At initial bacterial densities up to 10(4) cfu ml(-1), none of the three strains grew when transferrin iron saturation was below the full saturation point, whereas the bacteria grew consistently when transferrin was fully iron-saturated and there was non-transferrin-bound iron in the medium.	Iron	222-226	transferrin	Homo sapiens	200-211
11267776-2	2001	At initial bacterial densities up to 10(4) cfu ml(-1), none of the three strains grew when transferrin iron saturation was below the full saturation point, whereas the bacteria grew consistently when transferrin was fully iron-saturated and there was non-transferrin-bound iron in the medium.	Iron	222-226	transferrin	Homo sapiens	200-211
11230685-4	2001	Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption.	Iron	119-123	cytochrome b reductase 1	Mus musculus	30-35
11230685-5	2001	Thus, Dcytb provides an important element in the iron absorption pathway.	Iron	49-53	cytochrome b reductase 1	Mus musculus	6-11
11326747-6	2001	Our results suggest distinct roles for IRP1 and IRP2 in the regulation of iron homeostasis in the mammalian nervous system where IRP1 may provide a maintenance function in contrast to IRP2 that could participate in modulating proper CAN functions, including cardiopulmonary, gustatory as well as fine motor control.	Iron	74-78	iron responsive element binding protein 2	Homo sapiens	48-52
11359015-9	2001	On the contrary, the cutoff value of increments of hemoglobin of at least 0.2 g/dl after a 2-week intravenous iron trial had a sensitivity of 96.2% and a specificity of 100% in all patients (n = 32) and a sensitivity of 100% and a specificity of 100% after patients with transferrin saturation &lt;20% were excluded (n = 24).	Iron	110-114	transferrin	Homo sapiens	271-282
11343805-0	2001	Trichomonas vaginalis has two fibronectin-like iron-regulated genes.	Iron	47-51	fibronectin 1	Homo sapiens	30-41
11260010-3	2001	Furthermore, transferrin receptor polymorphism may influence the affinity of this receptor to its ligand with a subsequent increase of cellular iron absorption and storage.	Iron	144-148	transferrin	Homo sapiens	13-24
11316241-7	2001	Fe may have an additive effect, and cause a rapid improvement in anemia with relatively small doses of EPO.	Iron	0-2	erythropoietin	Homo sapiens	103-106
11316241-11	2001	In the follow-up study: to assess the ability of the maintenance of adequate iron stores for one year to achieve and maintain the target Hct of 35% with the minimum dose of EPO.	Iron	77-81	erythropoietin	Homo sapiens	173-176
11316241-32	2001	Fe during a subsequent maintenance phase allowed the target Hct of 35% to be reached and maintained with low-dose EPO in two-thirds of the predialysis patients and with no EPO at all in one-third.	Iron	0-2	erythropoietin	Homo sapiens	114-117
11264898-0	2001	Iron induces Bcl-2 expression in human dermal microvascular endothelial cells.	Iron	0-4	BCL2 apoptosis regulator	Homo sapiens	13-18
11264898-4	2001	Using immunohistochemistry and Western Blot analysis, we found that the extended cellular life span induced by iron was paralleled by an increase of Bcl-2 protein expression.	Iron	111-115	BCL2 apoptosis regulator	Homo sapiens	149-154
11494494-6	2001	In all teenagers, the activity of serum lysozyme and complement was directly related to the plasma level of iron and the school children"s physical fitness was closely correlated with plasma and blood cell iron concentrations.	Iron	108-112	lysozyme	Homo sapiens	40-48
11494494-6	2001	In all teenagers, the activity of serum lysozyme and complement was directly related to the plasma level of iron and the school children"s physical fitness was closely correlated with plasma and blood cell iron concentrations.	Iron	206-210	lysozyme	Homo sapiens	40-48
11262469-7	2001	CONCLUSION: Adjuvant recombinant human erythropoietin safely enhanced the efficacy of iron sucrose in the treatment of gestational iron-deficiency anemia resistant to orally administered iron alone.	Iron	86-90	erythropoietin	Homo sapiens	39-53
11482890-1	2001	High-dose chemotherapy of patients with haematological malignancies results in extracellular iron accumulation and appearance of non-transferrin-bound iron, which is thought to predispose the patients to septic infections and contribute to organ toxicity.	Iron	151-155	transferrin	Homo sapiens	133-144
11500065-7	2001	The total iron-binding capacity associated with each transferrin haplotype was haplotype 2 &gt; 1 &gt; 4 &gt; 3.	Iron	10-14	transferrin	Homo sapiens	53-64
11500065-14	2001	In White patients with Parkinson"s disease, a disorder in which there is abnormal iron deposition in the brain, the presence of transferrin haplotype 3 was in slight excess over the normal White population.	Iron	82-86	transferrin	Homo sapiens	128-139
11207678-15	2001	Pretreatment with the iron chelator deferoxamine (1 mmol/L) attenuated H2O2-mediated ACE inactivation, demonstrating that the effect of H2O2 was partly due to its conversion into *OH (Fenton reaction).	Iron	22-26	angiotensin I converting enzyme	Homo sapiens	85-88
11170717-0	2001	Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis.	Iron	124-128	heme oxygenase 2	Rattus norvegicus	30-46
11170717-2	2001	The neurotoxic heme is usually detoxified by the constitutive heme oxygenase-2 (HO-2) and its inducible isoform HO-1(heat shock protein 32) resulting in the formation of biliverdin which becomes reduced to bilirubin, carbon monoxide (CO), and iron.	Iron	243-247	heme oxygenase 2	Rattus norvegicus	62-78
11170717-2	2001	The neurotoxic heme is usually detoxified by the constitutive heme oxygenase-2 (HO-2) and its inducible isoform HO-1(heat shock protein 32) resulting in the formation of biliverdin which becomes reduced to bilirubin, carbon monoxide (CO), and iron.	Iron	243-247	heme oxygenase 2	Rattus norvegicus	80-84
11170717-5	2001	We have studied the alterations of cerebral HO-2 and HO-1 in relation to iron accumulations after defined cortical photothrombosis within the hindlimb area of the rat.	Iron	73-77	heme oxygenase 2	Rattus norvegicus	44-48
11512724-1	2001	The active metal site structure of transferrin with iron and copper atoms is investigated using metal K-XANES.	Iron	52-56	transferrin	Homo sapiens	35-46
11642031-0	2001	[Effect of alpha-lipoic acid preparations on bilirubin and transferrin levels and ferritin iron and transferrin iron content].	Iron	112-116	transferrin	Homo sapiens	100-111
11320857-3	2001	In the past decade, rHuEPO has been employed in neoplastic as well as in chronic inflammatory diseases associated with anemia, that recognizes a multifactorial pathogenesis: defective endogenous EPO production, impaired erythroid proliferation due to excessive release of inflammatory cytokines, intrinsic abnormalities of erythroid precursors, reticulo-endothelial blockage with reduced erythroid uptake of iron.	Iron	408-412	erythropoietin	Homo sapiens	23-26
11228961-6	2001	The use of iron compounds as a photo-oxidant is advantageous because Fe(III) hydroxide precipitate is an excellent adsorbent for As(V).	Iron	11-15	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	129-134
11642031-2	2001	In the cases of treatment in the patients suffering from hyperferremia the decrease in transferrin iron concentration in the whole blood and plasma occurs correlating with the enhancement of iron excretion from urine and decline of bilirubin level in serum.	Iron	99-103	transferrin	Homo sapiens	87-98
11642031-2	2001	In the cases of treatment in the patients suffering from hyperferremia the decrease in transferrin iron concentration in the whole blood and plasma occurs correlating with the enhancement of iron excretion from urine and decline of bilirubin level in serum.	Iron	191-195	transferrin	Homo sapiens	87-98
11092880-0	2001	Characterization of an iron-dependent regulatory sequence involved in the transcriptional control of AtFer1 and ZmFer1 plant ferritin genes by iron.	Iron	23-27	ferretin 1	Arabidopsis thaliana	101-107
11092880-0	2001	Characterization of an iron-dependent regulatory sequence involved in the transcriptional control of AtFer1 and ZmFer1 plant ferritin genes by iron.	Iron	143-147	ferretin 1	Arabidopsis thaliana	101-107
11456705-4	2001	This similarity is consistent with the presence of two axial ligands to the heme iron within the PS2.M--hemin complex, one of which is a water molecule.	Iron	81-85	taste 2 receptor member 64 pseudogene	Homo sapiens	97-100
11226433-3	2001	Here we describe the application of sensitive and specific HAVA measurement to characterize the formation of gamma-glutamyl semialdehyde in several domains of apoB-100 in LDL(1) (S(f) 7-12) and LDL(2) (S(f) 0-7) subfractions subjected to oxidative damage in the presence of iron in vitro.	Iron	274-278	apolipoprotein B	Homo sapiens	159-167
11342215-4	2001	HIRIP5 has highly conserved homologs in both prokaryotes and eukaryotes, including the NFU1 gene product which has been implicated in iron metabolism in mitochondria of the yeast Saccharomyces cerevisiae.	Iron	134-138	Nfu1p	Saccharomyces cerevisiae S288C	87-91
11078730-3	2001	Recently, we have shown that NO generators increase (59)Fe efflux from cells prelabeled with (59)Fe-transferrin (Wardrop, S. L., Watts, R. N., and Richardson, D. R. (2000) Biochemistry 39, 2748-2758).	Iron	56-58	transferrin	Homo sapiens	100-111
11241591-0	2001	The High-Valent Compound of Cytochrome P450: The Nature of the Fe-S Bond and the Role of the Thiolate Ligand as an Internal Electron Donor This research was sponsored in part by the Israeli Science Foundation (ISF) and the Binational German-Israeli Foundation (GIF).	Iron	63-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-43
11361003-1	2001	The transferrin receptor (TfR) is a N- and O-glycosylated transmembrane protein mediating the cellular iron uptake by binding and internalization of diferric transferrin.	Iron	103-107	transferrin	Homo sapiens	4-15
11160325-0	2001	Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation.	Iron	0-3	interleukin 4	Homo sapiens	17-21
11160325-6	2001	Fes appears to be a downstream kinase from Jak1/Jak3 in this process.	Iron	0-3	Janus kinase 1	Homo sapiens	43-47
11160325-7	2001	Further examination of downstream signaling demonstrates that kinase-inactive Fes inhibits the recruitment of phosphoinositide 3-kinase to the activated IL-4 receptor complex and decreases the activation of p70(S6k) kinase in response to IL-4.	Iron	78-81	interleukin 4	Homo sapiens	153-157
11160325-7	2001	Further examination of downstream signaling demonstrates that kinase-inactive Fes inhibits the recruitment of phosphoinositide 3-kinase to the activated IL-4 receptor complex and decreases the activation of p70(S6k) kinase in response to IL-4.	Iron	78-81	ubiquitin associated and SH3 domain containing B	Homo sapiens	207-222
11160325-7	2001	Further examination of downstream signaling demonstrates that kinase-inactive Fes inhibits the recruitment of phosphoinositide 3-kinase to the activated IL-4 receptor complex and decreases the activation of p70(S6k) kinase in response to IL-4.	Iron	78-81	interleukin 4	Homo sapiens	238-242
11171977-1	2001	A minor Hsp70 chaperone of the mitochondrial matrix of Saccharomyces cerevisiae, Ssq1, is involved in the formation or repair of Fe/S clusters and/or mitochondrial iron metabolism.	Iron	129-131	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	81-85
11171977-1	2001	A minor Hsp70 chaperone of the mitochondrial matrix of Saccharomyces cerevisiae, Ssq1, is involved in the formation or repair of Fe/S clusters and/or mitochondrial iron metabolism.	Iron	164-168	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	81-85
11171977-4	2001	Fe/S enzyme activities remain low in both jac1 and ssq1 mutant mitochondria even if normal mitochondrial iron levels are maintained.	Iron	105-109	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	51-55
11331104-1	2001	With alcoholism, there are marked disturbances in iron homeostasis that are linked to alterations in serum transferrin and ferritin concentrations.	Iron	50-54	transferrin	Rattus norvegicus	107-118
11331104-10	2001	There was a progressive decrease in transferrin iron saturation and ferritin/transferrin ratios for animals fed ethanol in the liquid diet, but not when ethanol was ingested from agar blocks.	Iron	48-52	transferrin	Rattus norvegicus	36-47
11368335-0	2001	Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine.	Iron	54-58	arachidonate 8-lipoxygenase	Mus musculus	75-90
11368335-8	2001	We conclude that mouse 8-LOX is catalytically competent with only four amino acid iron ligands, and that Ser-558 of the wild-type enzyme does not play an essential role in catalysis.	Iron	82-86	arachidonate 8-lipoxygenase	Mus musculus	23-28
11327820-0	2001	Crystal structures and iron release properties of mutants (K206A and K296A) that abolish the dilysine interaction in the N-lobe of human transferrin.	Iron	23-27	transferrin	Homo sapiens	137-148
11327820-1	2001	Human transferrin (Tf) is responsible for the binding and transport of iron in the bloodstream of vertebrates.	Iron	71-75	transferrin	Homo sapiens	6-17
11327820-1	2001	Human transferrin (Tf) is responsible for the binding and transport of iron in the bloodstream of vertebrates.	Iron	71-75	transferrin	Homo sapiens	19-21
11327820-2	2001	Delivery of this bound iron to cells occurs by a process of receptor-mediated endocytosis during which Tf releases its iron at the reduced endosomal pH of approximately 5.6.	Iron	23-27	transferrin	Homo sapiens	103-105
11327820-2	2001	Delivery of this bound iron to cells occurs by a process of receptor-mediated endocytosis during which Tf releases its iron at the reduced endosomal pH of approximately 5.6.	Iron	119-123	transferrin	Homo sapiens	103-105
11327820-3	2001	Iron release from Tf involves a large conformational change in which the two domains that enclose the binding site in each lobe move apart.	Iron	0-4	transferrin	Homo sapiens	18-20
11327820-4	2001	We have examined the role of two lysines, Lys206 and Lys296, that form a hydrogen-bonded pair close to the N-lobe binding site of human Tf and have been proposed to form a pH-sensitive trigger for iron release.	Iron	197-201	transferrin	Homo sapiens	136-138
11166808-8	2001	The dependence of the stability of LOX immobilized on epoxy activated supports on the coupling conditions was attributed to a modulation of the ligand environment of the iron in the active site and consequently its reactivity.	Iron	154-158	seed linoleate 9S-lipoxygenase-3	Glycine max	35-38
11157499-0	2001	Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy.	Iron	27-31	transferrin	Homo sapiens	58-69
11157499-0	2001	Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy.	Iron	76-80	transferrin	Homo sapiens	58-69
11157499-1	2001	This study introduces a method for monitoring a component of serum non-transferrin-bound iron (NTBI), termed "desferrioxamine-chelatable iron" (DCI).	Iron	89-93	transferrin	Homo sapiens	71-82
11157499-1	2001	This study introduces a method for monitoring a component of serum non-transferrin-bound iron (NTBI), termed "desferrioxamine-chelatable iron" (DCI).	Iron	137-142	transferrin	Homo sapiens	71-82
11157499-8	2001	A similar iron transfer from L1 to apo-transferrin was observed in vitro, lending experimental support to the notion that L1 can shuttle iron in vivo to other high-affinity ligands.	Iron	10-14	transferrin	Homo sapiens	39-50
11157499-8	2001	A similar iron transfer from L1 to apo-transferrin was observed in vitro, lending experimental support to the notion that L1 can shuttle iron in vivo to other high-affinity ligands.	Iron	137-141	transferrin	Homo sapiens	39-50
11422223-3	2001	In all these diseases this anaemia or chronic disease is at least partially due to excessive production of cytokines and leukotrines that interfere both with the effect of erythropoietin (EPO) at the bone marrow and the release of stored iron in the reticuloendothelial system.	Iron	238-242	erythropoietin	Homo sapiens	188-191
11208786-8	2001	Collectively these results suggest that P. multocida has a single, novel receptor protein (TbpA) that is capable of efficiently mediating iron acquisition from bovine transferrin without the involvement of a second receptor protein (TbpB).	Iron	138-142	serotransferrin	Bos taurus	167-178
11169456-1	2001	Three mechanisms of iron uptake by rat erythroid cells were identified, two with non-transferrin-bound iron (NTBI) and one with transferrin-bound iron (Fe-Tf).	Iron	20-24	transferrin	Rattus norvegicus	85-96
11169456-1	2001	Three mechanisms of iron uptake by rat erythroid cells were identified, two with non-transferrin-bound iron (NTBI) and one with transferrin-bound iron (Fe-Tf).	Iron	20-24	transferrin	Rattus norvegicus	128-139
11027687-0	2001	Effect of heme iron valence state on the conformation of cytochrome c and its association with membrane interfaces.	Iron	15-19	cytochrome c, somatic	Homo sapiens	57-69
11207901-6	2001	CONCLUSIONS: These findings suggest that IFN-alpha treatment may decrease stimuli for fibrogenesis, at least in part, by reducing the hepatic iron deposition in patients with chronic hepatitis C.	Iron	142-146	interferon alpha 1	Homo sapiens	41-50
11060297-3	2001	Homogeneous pig brain mitochondrial glycerol-3-phosphate dehydrogenase was activated by either 150 microm L-ascorbic acid (56%) or 300 microm iron (Fe(2+) or Fe(3+) (62%)) and 2.6-fold by the addition of both L-ascorbic acid and iron.	Iron	142-146	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	36-70
11060297-3	2001	Homogeneous pig brain mitochondrial glycerol-3-phosphate dehydrogenase was activated by either 150 microm L-ascorbic acid (56%) or 300 microm iron (Fe(2+) or Fe(3+) (62%)) and 2.6-fold by the addition of both L-ascorbic acid and iron.	Iron	148-150	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	36-70
11060297-3	2001	Homogeneous pig brain mitochondrial glycerol-3-phosphate dehydrogenase was activated by either 150 microm L-ascorbic acid (56%) or 300 microm iron (Fe(2+) or Fe(3+) (62%)) and 2.6-fold by the addition of both L-ascorbic acid and iron.	Iron	158-160	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	36-70
11060297-3	2001	Homogeneous pig brain mitochondrial glycerol-3-phosphate dehydrogenase was activated by either 150 microm L-ascorbic acid (56%) or 300 microm iron (Fe(2+) or Fe(3+) (62%)) and 2.6-fold by the addition of both L-ascorbic acid and iron.	Iron	229-233	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	36-70
11060297-5	2001	The activation of pure glycerol-3-phosphate dehydrogenase by either L-ascorbic acid or iron or its combination could be totally inhibited by 200 microm propyl gallate.	Iron	87-91	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	23-57
11060297-7	2001	The combined data support the conclusion that l-ascorbic acid is a physiological activator of mitochondrial glycerol-3-phosphate dehydrogenase, that the enzyme is potently inhibited by agents that specifically inhibit certain classes of di-iron metalloenzymes, and that the enzyme is chiefly responsible for the proximal signal events in INS-1 cell glucose-stimulated insulin release.	Iron	240-244	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	108-142
11148040-7	2001	In addition, the CO adduct of ferrous CBS has vibrational frequencies characteristic of a histidine-heme-CO complex in a hydrophobic environment, and indicates that the Fe-S(Cys) bond is labile.	Iron	169-173	cystathionine beta-synthase	Homo sapiens	38-41
11166663-6	2001	RESULTS: Nuclear factor kappa B (NF-kappaB) activation, regulating proviral transcription, can be influenced by iron through the production of reactive oxygen species.	Iron	112-116	nuclear factor kappa B subunit 1	Homo sapiens	9-31
11166663-6	2001	RESULTS: Nuclear factor kappa B (NF-kappaB) activation, regulating proviral transcription, can be influenced by iron through the production of reactive oxygen species.	Iron	112-116	nuclear factor kappa B subunit 1	Homo sapiens	33-42
11175792-2	2001	Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC).	Iron	116-120	iron responsive element binding protein 2	Homo sapiens	54-58
11027687-6	2001	Magnetic circular dichroism and CD results show that the interaction of both ferrous and ferric cytochrome c with charged interfaces promotes conformational changes in the alpha-helix content, tertiary structure, and heme iron spin state.	Iron	222-226	cytochrome c, somatic	Homo sapiens	96-108
11027687-7	2001	Moreover, the association of cytochrome c with different liposomes is sensitive to the heme iron valence state.	Iron	92-96	cytochrome c, somatic	Homo sapiens	29-41
11136173-12	2001	A similar degree of C3 upregulation was reproduced when iron-poor transferrin, apotransferrin, was used instead.	Iron	56-60	transferrin	Homo sapiens	66-77
11198712-1	2001	BACKGROUND: Transferrin is a globular protein synthesized in the liver that is responsible for iron transport in plasma.	Iron	95-99	transferrin	Homo sapiens	12-23
11642302-3	2001	Adaptive response by 5~20 cGy of such C- or Fe-ion irradiation to both lethal and mutagenic effects of the challenging X-ray exposure (1~3 Gy) was difficult to be seen in this TK6 cells, but surprisingly, a relatively high level of p53 and its related proteins induction was observed after low-dose irradiations of heavy-ions.	Iron	44-46	tumor protein p53	Homo sapiens	232-235
11133518-0	2001	Cytochrome P-450 as a source of catalytic iron in minimal change nephrotic syndrome in rats.	Iron	42-46	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
11133518-3	2001	We examined the role of cytochrome P-450 (CYP) as a source of catalytic iron in a model MCNS induced by single injection of PAN to rats.	Iron	72-76	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	24-40
11133518-3	2001	We examined the role of cytochrome P-450 (CYP) as a source of catalytic iron in a model MCNS induced by single injection of PAN to rats.	Iron	72-76	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-45
11133518-5	2001	Administration of CYP inhibitors significantly prevented the injury-induced loss of CYP content and the increase in the catalytic iron in the glomeruli accompanied by a marked decrease in proteinuria.	Iron	130-134	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	18-21
11133518-6	2001	In an in vitro study utilizing glomerular epithelial cells (GEC), CYP inhibitors also markedly prevented the PAN-induced increase in the catalytic iron and hydroxyl radical formation accompanied by significant protection against PAN-induced cytotoxicity.	Iron	147-151	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-69
11133518-7	2001	Taken together our data indicate that the CYP, a group of heme protein, may serve as a significant source of this catalytic iron.	Iron	124-128	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-45
11340304-8	2001	These data suggest that the observed increase in NO production by PTC in response to iron is due to increased transcription of iNOS.	Iron	85-89	nitric oxide synthase 2	Homo sapiens	127-131
11299801-2	2001	Transferrin and its receptor are required for entry of iron into the cell.	Iron	55-59	transferrin	Homo sapiens	0-11
11897880-4	2001	An adequate intake of iron, zinc, and vitamins A, E, B6 and B12 is particularly important but excess intakes can also impair immune function.	Iron	22-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	60-63
11358358-0	2001	Analysis of the NRAMP1 gene implicated in iron transport: association with multiple sclerosis and age effects.	Iron	42-46	solute carrier family 11 member 1	Homo sapiens	16-22
11358358-7	2001	Although it remains to be determined whether the disease phenotype in MS patients with allele 5 of the NRAMP1 promoter polymorphism is directly related to dysregulation of iron or modified susceptibility to viral infection and/or autoimmunity, a combination of these processes most likely underlies the disease phenotype in these patients.	Iron	172-176	solute carrier family 11 member 1	Homo sapiens	103-109
11855786-13	2001	Increased production of IL-6 and IL-8 might have contributed to abnormalities in iron metabolism and it is probably due to overstimulation of macrophages.	Iron	81-85	interleukin 6	Homo sapiens	24-28
11855786-13	2001	Increased production of IL-6 and IL-8 might have contributed to abnormalities in iron metabolism and it is probably due to overstimulation of macrophages.	Iron	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
11500943-0	2001	Iron-induced oxidative stress up-regulates calreticulin levels in intestinal epithelial (Caco-2) cells.	Iron	0-4	calreticulin	Homo sapiens	43-55
11920245-1	2001	INTRODUCTION: Congenital dyserythropoietic anemia type 1 (CDA1) patients may suffer from iron overload, associated with oxidative damage.	Iron	89-93	codanin 1	Homo sapiens	14-56
11920245-1	2001	INTRODUCTION: Congenital dyserythropoietic anemia type 1 (CDA1) patients may suffer from iron overload, associated with oxidative damage.	Iron	89-93	codanin 1	Homo sapiens	58-62
28452446-12	2001	Patients with CRP levels higher than 1 mg/dL showed lower serum albumin, iron, hemoglobin, and transferrin levels, and higher ferritin values and leukocyte counts.	Iron	73-77	C-reactive protein	Homo sapiens	14-17
28452446-13	2001	Under logistic regression analysis, CRP levels higher and lower than 1 mg/dL were significantly associated with serum albumin [p = 0.01; odds ratio (OR): 0.15], iron (p = 0.006; OR: 0.96), transferrin (p = 0.004; OR: 0.97), and hemoglobin (p = 0.02; OR: 0.67).	Iron	161-165	C-reactive protein	Homo sapiens	36-39
11500943-2	2001	Mobilferrin, a cytosolic isoform of calreticulin, has been proposed to be an iron carrier for iron recently incoming into intestinal cells.	Iron	77-81	calreticulin	Homo sapiens	36-48
11500943-2	2001	Mobilferrin, a cytosolic isoform of calreticulin, has been proposed to be an iron carrier for iron recently incoming into intestinal cells.	Iron	94-98	calreticulin	Homo sapiens	36-48
11500943-3	2001	To test the hypothesis that iron could affect calreticulin expression, we investigated the possible associations of calreticulin with iron metabolism.	Iron	28-32	calreticulin	Homo sapiens	46-58
11500943-4	2001	To that end, using Caco-2 cells as a model of intestinal epithelium, the mass and mRNA levels of calreticulin were evaluated as a function of the iron concentration in the culture media.	Iron	146-150	calreticulin	Homo sapiens	97-109
11500943-5	2001	Increasing the iron content in the culture from 1 to 20 microM produced an increase in calreticulin mRNA and a two-fold increase in calreticulin.	Iron	15-19	calreticulin	Homo sapiens	87-99
11500943-5	2001	Increasing the iron content in the culture from 1 to 20 microM produced an increase in calreticulin mRNA and a two-fold increase in calreticulin.	Iron	15-19	calreticulin	Homo sapiens	132-144
11500943-7	2001	Co-culture of cells with the antioxidants quercetin, dimethyltiourea and N-acetyl cysteine abolished both the iron-induced oxidative damage and the iron-induced increase in calreticulin.	Iron	148-152	calreticulin	Homo sapiens	173-185
11500943-8	2001	We postulate that the iron-induced expression of calreticulin is part of the cellular response to oxidative stress generated by iron.	Iron	22-26	calreticulin	Homo sapiens	49-61
11500943-8	2001	We postulate that the iron-induced expression of calreticulin is part of the cellular response to oxidative stress generated by iron.	Iron	128-132	calreticulin	Homo sapiens	49-61
11134438-0	2001	Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants.	Iron	22-26	erythropoietin	Homo sapiens	64-78
11217149-4	2001	We hypothesized that CSE increase asbestos-induced AEC injury by triggering PARP activation resulting from DNA damage caused by iron-induced free radicals.	Iron	128-132	poly(ADP-ribose) polymerase 1	Homo sapiens	76-80
21336750-2	2001	One target of iron-acquisition systems is transferrin (Tf), which is the major glycoprotein responsible for the transport of iron in the extracellular milieu of vertebrates.	Iron	14-18	transferrin	Homo sapiens	42-53
21336750-2	2001	One target of iron-acquisition systems is transferrin (Tf), which is the major glycoprotein responsible for the transport of iron in the extracellular milieu of vertebrates.	Iron	14-18	transferrin	Homo sapiens	55-57
21336750-2	2001	One target of iron-acquisition systems is transferrin (Tf), which is the major glycoprotein responsible for the transport of iron in the extracellular milieu of vertebrates.	Iron	125-129	transferrin	Homo sapiens	42-53
11509682-1	2001	Provision of sufficient available iron is a prerequisite to ensure the optimal response to recombinant human erythropoietin (rHuEpo).	Iron	34-38	erythropoietin	Homo sapiens	109-123
11590253-4	2001	Iron deficiency, whether absolute or functional, is considered to be the most important, and it is widely accepted that maintaining adequate iron levels reduces rh-Epo dosage requirement and improves efficacy in haemodialysis patients.	Iron	141-145	erythropoietin	Homo sapiens	164-167
11590253-5	2001	Infection and inflammation have been shown to influence responsiveness to rh-Epo by disrupting iron metabolism and eliciting the release of cytokines that inhibit erythropoiesis.	Iron	95-99	erythropoietin	Homo sapiens	77-80
11134438-12	2001	CONCLUSIONS: In stable VLBW infants receiving EPO treatment, parenteral supplementation with 2 mg/kg/day of iron sucrose results in a small, but significant, augmentation of erythropoiesis beyond that of r-HuEPO and enteral iron alone.	Iron	108-112	erythropoietin	Homo sapiens	46-49
11208917-3	2001	We have also shown that reactive iron (Fe3+) and cGMP staining spatially resemble that of HO-1; which, in turn, colocalizes in motor neurons with transcription factors: Fas-associated protein containing death domain (FADD), tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and p53.	Iron	33-37	TNF superfamily member 10	Homo sapiens	287-292
11208917-3	2001	We have also shown that reactive iron (Fe3+) and cGMP staining spatially resemble that of HO-1; which, in turn, colocalizes in motor neurons with transcription factors: Fas-associated protein containing death domain (FADD), tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and p53.	Iron	33-37	tumor protein p53	Homo sapiens	298-301
21336750-2	2001	One target of iron-acquisition systems is transferrin (Tf), which is the major glycoprotein responsible for the transport of iron in the extracellular milieu of vertebrates.	Iron	125-129	transferrin	Homo sapiens	55-57
11842873-0	2001	Expression of transferrin mRNA in rat oligodendrocytes is iron-independent and changes with increasing age.	Iron	58-62	transferrin	Rattus norvegicus	14-25
11887827-1	2001	The vast majority of erythropoietin (EPO)-treated peritoneal dialysis (PD) patients require iron supplementation.	Iron	92-96	erythropoietin	Homo sapiens	21-35
11087229-4	2000	Adventitial NOS-2 activity largely accounted for 1) the relaxing effect of L-arginine in rings exposed to LPS in vivo, 2) generation of an "NO store" revealed by N-acetylcysteine-induced relaxation, and 3) formation of protein-bound dinitrosyl iron complexes in the medial layer of aortic rings exposed to LPS in vitro.	Iron	244-248	nitric oxide synthase 2	Rattus norvegicus	12-17
11887827-1	2001	The vast majority of erythropoietin (EPO)-treated peritoneal dialysis (PD) patients require iron supplementation.	Iron	92-96	erythropoietin	Homo sapiens	37-40
11300537-4	2001	By dismantling the test pole transformers into the "iron core and coil portion" and cleaning the components, we achieved a residual PCB amount that was below the limit of detection (0.05 mg-PCB/kg-material).	Iron	52-56	pyruvate carboxylase	Homo sapiens	132-135
11123951-1	2000	The Fe-S cluster formation proteins NifU and NifS are essential for viability in the ulcer causing human pathogen Helicobacter pylori.	Iron	4-8	iron-sulfur cluster assembly enzyme	Homo sapiens	36-40
11123951-6	2000	Purified NifU is a red protein that contains approximately 1.5 atoms of iron per monomer.	Iron	72-76	iron-sulfur cluster assembly enzyme	Homo sapiens	9-13
11123951-8	2000	The primary structure of NifU also contains the three conserved cysteine residues which are involved in providing the scaffold for the assembly of a transient Fe-S cluster for insertion into apoprotein.	Iron	159-163	iron-sulfur cluster assembly enzyme	Homo sapiens	25-29
11123951-11	2000	The results here indicate that the NifU type of Fe-S cluster formation proteins is not specific for maturation of the nitrogenase proteins and, as H. pylori lacks other Fe-S cluster assembly proteins, that the H. pylori NifS and NifU are responsible for the assembly of many (non-nitrogenase) Fe-S clusters.	Iron	48-52	iron-sulfur cluster assembly enzyme	Homo sapiens	35-39
11123951-11	2000	The results here indicate that the NifU type of Fe-S cluster formation proteins is not specific for maturation of the nitrogenase proteins and, as H. pylori lacks other Fe-S cluster assembly proteins, that the H. pylori NifS and NifU are responsible for the assembly of many (non-nitrogenase) Fe-S clusters.	Iron	48-52	iron-sulfur cluster assembly enzyme	Homo sapiens	229-233
11123951-11	2000	The results here indicate that the NifU type of Fe-S cluster formation proteins is not specific for maturation of the nitrogenase proteins and, as H. pylori lacks other Fe-S cluster assembly proteins, that the H. pylori NifS and NifU are responsible for the assembly of many (non-nitrogenase) Fe-S clusters.	Iron	169-173	iron-sulfur cluster assembly enzyme	Homo sapiens	35-39
11120873-6	2000	The Met4, Met31, and Met32 transcription factors may play a role in coregulating genes involved in copper and iron metabolism.	Iron	110-114	Met4p	Saccharomyces cerevisiae S288C	4-8
11120873-6	2000	The Met4, Met31, and Met32 transcription factors may play a role in coregulating genes involved in copper and iron metabolism.	Iron	110-114	Met32p	Saccharomyces cerevisiae S288C	21-26
11113055-1	2000	BACKGROUND: Heme oxygenase (HO)-1 is an enzyme that degrades heme to generate CO (a vasodilatory gas), iron, and the potent antioxidant bilirubin.	Iron	103-107	heme oxygenase 1	Mus musculus	12-33
11300537-3	2001	The results are summarized as follows: (1) Based on the cleaning test results, we made an estimate of the residual PCB amount on iron and copper components.	Iron	129-133	pyruvate carboxylase	Homo sapiens	115-118
11027676-1	2000	The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	73-77	transferrin	Homo sapiens	4-15
11027676-1	2000	The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	73-77	transferrin	Homo sapiens	26-28
11027676-2	2000	A second receptor for Tf, TfR2, was recently identified and found to be functional for iron uptake in transfected cells (Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., Said, J. W., and Koeffler, H. P. (2000) J. Biol.	Iron	87-91	transferrin	Homo sapiens	22-24
11027676-10	2000	The affinity of TfR2 for iron-loaded Tf was determined to be 27 nm, 25-fold lower than the affinity of TfR for Tf.	Iron	25-29	transferrin	Homo sapiens	16-18
11027676-10	2000	The affinity of TfR2 for iron-loaded Tf was determined to be 27 nm, 25-fold lower than the affinity of TfR for Tf.	Iron	25-29	transferrin	Homo sapiens	37-39
11027676-11	2000	These results imply that HFE regulates Tf-mediated iron uptake only from the classical TfR and that TfR2 does not compete for HFE binding in cells expressing both forms of TfR.	Iron	51-55	transferrin	Homo sapiens	39-41
11096041-7	2000	The percentage of patients in each of the 18 ESRD Networks with hematocrits of 33% or greater correlated inversely with the percentage of patients administered intravenous iron (r = -0.53; P: = 0.03) after adjustment for dose of erythropoietin.	Iron	172-176	erythropoietin	Homo sapiens	229-243
11151887-9	2000	Biochemical tests in PCT patients showed iron overload with transferrin saturation = 47.3 +/- 20.7% and ferritin = 566.8 +/- 425 ng/ml.	Iron	41-45	transferrin	Homo sapiens	60-71
11085915-3	2000	Iron homoeostasis is controlled through several genes, an increasing number of which have been found to contain non-coding sequences [i.e. the iron-responsive elements (IREs)] which are recognized at the mRNA level by two cytoplasmic iron-regulatory proteins (IRP-1 and IRP-2).	Iron	143-147	iron responsive element binding protein 2	Homo sapiens	270-275
11114684-0	2000	Assessment of iron status using plasma transferrin receptor in pregnant women with and without human immunodeficiency virus infection in Malawi.	Iron	14-18	transferrin	Homo sapiens	39-50
11085915-3	2000	Iron homoeostasis is controlled through several genes, an increasing number of which have been found to contain non-coding sequences [i.e. the iron-responsive elements (IREs)] which are recognized at the mRNA level by two cytoplasmic iron-regulatory proteins (IRP-1 and IRP-2).	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	270-275
11114684-2	2000	OBJECTIVE: To gain insight into iron status in HIV-infected pregnant women using plasma transferrin receptor and related indicators of anemia.	Iron	32-36	transferrin	Homo sapiens	88-99
11128996-1	2000	Proteins of the transferrin family play a key role in iron homeostasis through their extremely strong binding of iron, as Fe3+.	Iron	54-58	transferrin	Homo sapiens	16-27
11169417-6	2000	Importantly, the "protective" effect of iron delivery correlated with the presence, at the site of inoculation, of lower levels of IL-4 and IL-10 transcripts while both IFN-gamma and inducible nitric oxide synthase transcripts were at higher levels.	Iron	40-44	interleukin 10	Mus musculus	140-145
11169417-6	2000	Importantly, the "protective" effect of iron delivery correlated with the presence, at the site of inoculation, of lower levels of IL-4 and IL-10 transcripts while both IFN-gamma and inducible nitric oxide synthase transcripts were at higher levels.	Iron	40-44	interferon gamma	Mus musculus	169-178
11083823-0	2000	Identification of discrete domains within gonococcal transferrin-binding protein A that are necessary for ligand binding and iron uptake functions.	Iron	125-129	transferrin	Homo sapiens	53-64
11083823-1	2000	The availability of free iron in vivo is strictly limited, in part by the iron-binding protein transferrin.	Iron	25-29	transferrin	Homo sapiens	95-106
11083823-1	2000	The availability of free iron in vivo is strictly limited, in part by the iron-binding protein transferrin.	Iron	74-78	transferrin	Homo sapiens	95-106
11083823-3	2000	can sequester iron from this protein, dependent upon two iron-repressible, transferrin-binding proteins (TbpA and TbpB).	Iron	14-18	transferrin	Homo sapiens	75-86
11083823-3	2000	can sequester iron from this protein, dependent upon two iron-repressible, transferrin-binding proteins (TbpA and TbpB).	Iron	57-61	transferrin	Homo sapiens	75-86
11083823-9	2000	These data implicate putative loops 4 and 5 as critical determinants for receptor function and transferrin-iron uptake by gonococcal TbpA.	Iron	107-111	transferrin	Homo sapiens	95-106
11083823-10	2000	The phenotype of the DeltaL8TbpA mutant suggests that high-affinity ligand interaction is required for transferrin-iron internalization.	Iron	115-119	transferrin	Homo sapiens	103-114
11128996-1	2000	Proteins of the transferrin family play a key role in iron homeostasis through their extremely strong binding of iron, as Fe3+.	Iron	113-117	transferrin	Homo sapiens	16-27
11099894-5	2000	It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf.	Iron	91-95	transferrin	Homo sapiens	268-270
11131442-0	2000	Non-alcoholic steatohepatitis with iron: part of insulin resistance-associated hepatic iron overload?	Iron	35-39	insulin	Homo sapiens	49-56
11131442-0	2000	Non-alcoholic steatohepatitis with iron: part of insulin resistance-associated hepatic iron overload?	Iron	87-91	insulin	Homo sapiens	49-56
11102463-5	2000	GDF-15/MIC-1 is a potent survival promoting and protective factor for cultured and iron-intoxicated dopaminergic (DAergic) neurons cultured from the embryonic rat midbrain floor.	Iron	83-87	growth differentiation factor 15	Rattus norvegicus	0-6
11140702-17	2000	In addition, iron-overload was associated with up-regulation of renal eNOS and iNOS expressions when compared with the control and Fe-depleted rats that showed comparable values.	Iron	13-17	nitric oxide synthase 2	Rattus norvegicus	79-83
11140702-18	2000	In conclusion, chronic iron overload resulted in iron deposition in the glomeruli and proximal tubules with various renal lesions and evidence of increased ROS activity, enhanced ROS-mediated inactivation, and sequestration of NO and compensatory up-regulation of renal eNOS and iNOS expressions.	Iron	23-27	nitric oxide synthase 2	Rattus norvegicus	279-283
16649342-3	2000	Patients who receive Epoetin alfa therapy typically require intravenous iron supplementation to ensure proper red cell formation.	Iron	72-76	erythropoietin	Homo sapiens	21-28
11099894-0	2000	The importance of non-transferrin bound iron in disorders of iron metabolism.	Iron	40-44	transferrin	Homo sapiens	22-33
11099894-0	2000	The importance of non-transferrin bound iron in disorders of iron metabolism.	Iron	61-65	transferrin	Homo sapiens	22-33
11099894-1	2000	The concept of non-transferrin bound iron (NTBI) was introduced 22 years ago by Hershko et al.	Iron	37-41	transferrin	Homo sapiens	19-30
11104500-6	2000	Using MRI techniques and CSF analysis of iron-related protein, studies have suggested a reduction in brain iron concentration occurs in RLS patients.	Iron	41-45	RLS1	Homo sapiens	136-139
11104500-6	2000	Using MRI techniques and CSF analysis of iron-related protein, studies have suggested a reduction in brain iron concentration occurs in RLS patients.	Iron	107-111	RLS1	Homo sapiens	136-139
11104500-7	2000	The relevance of CNS iron metabolism to the pathophysiology of RLS is discussed.	Iron	21-25	RLS1	Homo sapiens	63-66
11099894-5	2000	It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf.	Iron	37-41	transferrin	Homo sapiens	157-168
11099894-5	2000	It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf.	Iron	37-41	transferrin	Homo sapiens	170-172
11099901-0	2000	Desferrioxamine-chelatable iron (DCI), a component of serum non-transferrin-bound iron (NTBI) used for assessing iron chelation therapy.	Iron	27-31	transferrin	Homo sapiens	64-75
11099894-5	2000	It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf.	Iron	37-41	transferrin	Homo sapiens	268-270
11099894-5	2000	It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf.	Iron	91-95	transferrin	Homo sapiens	268-270
11099894-5	2000	It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf.	Iron	91-95	transferrin	Homo sapiens	268-270
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	103-107	transferrin	Homo sapiens	157-168
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	135-139	transferrin	Homo sapiens	157-168
11050162-7	2000	These results are consistent with the hypothesis that the generation of oxygen/nitrogen species and unsaturated aldehydes from iron and copper overload in hemochromatosis and WD causes mutations in the p53 tumor suppressor gene.	Iron	127-131	tumor protein p53	Homo sapiens	202-205
11068183-2	2000	In this study, we examined neuronal and glial cells to clarify which contributes most to metal accumulation after internalization through the transferrin-independent iron uptake (Tf-IU) systems in primary neuronal and glial predominant (NP and GP) cells from rat cerebral cortex, which affect the accumulation of transition metals in a variety of cultured cells.	Iron	166-170	transferrin	Rattus norvegicus	142-153
11071875-1	2000	Microperoxidase 8 (MP8) is a heme octapeptide, obtained by enzymatic hydrolysis of heart cytochrome c, in which a histidine is axially coordinated to the heme iron, and acts as its fifth ligand.	Iron	159-163	cytochrome c, somatic	Homo sapiens	89-101
29711670-0	2000	The High-Valent Compound of Cytochrome P450: The Nature of the Fe-S Bond and the Role of the Thiolate Ligand as an Internal Electron Donor.	Iron	63-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-43
11243246-3	2000	Catalase suppressed the cytotoxicity induced by iron ions in Lu106 cells.	Iron	48-52	catalase	Homo sapiens	0-8
11045680-0	2000	Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies.	Iron	71-75	pantothenate kinase 2	Homo sapiens	97-103
11045680-2	2000	Magnetic resonance imaging showed decreased intensity in the globus pallidus, substantia nigra, and dentate nuclei in T2-weighted images, supporting the clinical diagnosis of neurodegeneration with brain iron accumulation type 1 (NBIA-1; formerly known as Hallervorden-Spatz syndrome).	Iron	204-208	pantothenate kinase 2	Homo sapiens	230-236
11045680-4	2000	Histologically, features typical of NBIA-1 were found including widespread axonal spheroids and large deposits of iron pigment in the discolored regions.	Iron	114-118	pantothenate kinase 2	Homo sapiens	36-42
11053005-1	2000	The divalent metal transporter (DMT1, also known as NRAMP2 or DCT1) is the likely target for regulation of intestinal iron absorption by iron stores.	Iron	118-122	solute carrier family 11 member 2	Rattus norvegicus	32-36
11146312-1	2000	BACKGROUND: Parenteral iron therapy is required in a majority of chronic dialysis patients who are receiving recombinant human erythropoietin (r-HuEPO) in order to provide adequate iron for erythropoiesis.	Iron	23-27	erythropoietin	Homo sapiens	127-141
11053005-1	2000	The divalent metal transporter (DMT1, also known as NRAMP2 or DCT1) is the likely target for regulation of intestinal iron absorption by iron stores.	Iron	118-122	solute carrier family 11 member 2	Rattus norvegicus	52-58
11053005-1	2000	The divalent metal transporter (DMT1, also known as NRAMP2 or DCT1) is the likely target for regulation of intestinal iron absorption by iron stores.	Iron	137-141	solute carrier family 11 member 2	Rattus norvegicus	32-36
11053005-1	2000	The divalent metal transporter (DMT1, also known as NRAMP2 or DCT1) is the likely target for regulation of intestinal iron absorption by iron stores.	Iron	137-141	solute carrier family 11 member 2	Rattus norvegicus	52-58
11053005-5	2000	At 1.5 h after dietary iron intake in +/b and b/b rats, DMT1 was internalized into cytoplasmic vesicles.	Iron	23-27	solute carrier family 11 member 2	Rattus norvegicus	56-60
11053005-6	2000	At 1.5 and 3 h after iron intake in +/b and b/b rats, there was a rapid decrease of DMT1 mRNA and a transient increase of DMT1 protein.	Iron	21-25	solute carrier family 11 member 2	Rattus norvegicus	84-88
11053005-9	2000	Thus intestinal DMT1 rapidly responds to dietary iron in both +/b and b/b rats.	Iron	49-53	solute carrier family 11 member 2	Rattus norvegicus	16-20
11053005-10	2000	The internalization of DMT1 may be an acute regulatory mechanism to limit iron uptake.	Iron	74-78	solute carrier family 11 member 2	Rattus norvegicus	23-27
11193083-0	2000	Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution ICP-MS. Serum transferrin (Tf) is an iron-binding glycoprotein.	Iron	46-50	transferrin	Homo sapiens	66-77
11060020-3	2000	Here we report cloning of the human homologs to IscU and NifU, iron-binding proteins that play a critical role in Fe-S cluster assembly in bacteria.	Iron	63-67	iron-sulfur cluster assembly enzyme	Homo sapiens	48-52
11193083-0	2000	Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution ICP-MS. Serum transferrin (Tf) is an iron-binding glycoprotein.	Iron	46-50	transferrin	Homo sapiens	124-135
11193083-0	2000	Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution ICP-MS. Serum transferrin (Tf) is an iron-binding glycoprotein.	Iron	46-50	transferrin	Homo sapiens	137-139
11193083-0	2000	Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution ICP-MS. Serum transferrin (Tf) is an iron-binding glycoprotein.	Iron	147-151	transferrin	Homo sapiens	66-77
11193083-0	2000	Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution ICP-MS. Serum transferrin (Tf) is an iron-binding glycoprotein.	Iron	147-151	transferrin	Homo sapiens	124-135
11193083-0	2000	Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution ICP-MS. Serum transferrin (Tf) is an iron-binding glycoprotein.	Iron	147-151	transferrin	Homo sapiens	137-139
11193083-2	2000	In the present study, the chemical forms of co-existing Al and Fe bound to human serum Tf were studied by combined on-line HPLC and high-resolution ICP-MS (HPLC-HR-ICP-MS).	Iron	63-65	transferrin	Homo sapiens	87-89
11060020-3	2000	Here we report cloning of the human homologs to IscU and NifU, iron-binding proteins that play a critical role in Fe-S cluster assembly in bacteria.	Iron	63-67	iron-sulfur cluster assembly enzyme	Homo sapiens	57-61
11060020-3	2000	Here we report cloning of the human homologs to IscU and NifU, iron-binding proteins that play a critical role in Fe-S cluster assembly in bacteria.	Iron	114-116	iron-sulfur cluster assembly enzyme	Homo sapiens	48-52
11060020-3	2000	Here we report cloning of the human homologs to IscU and NifU, iron-binding proteins that play a critical role in Fe-S cluster assembly in bacteria.	Iron	114-116	iron-sulfur cluster assembly enzyme	Homo sapiens	57-61
11060020-5	2000	Biochemical analyses demonstrate that IscU proteins specifically associate with IscS, a cysteine desulfurase that is proposed to sequester inorganic sulfur for Fe-S cluster assembly.	Iron	160-162	iron-sulfur cluster assembly enzyme	Homo sapiens	38-42
11060020-6	2000	Protein complexes containing IscU and IscS can be found in the mitochondria as well as in the cytosol, implying that Fe-S cluster assembly takes place in multiple subcellular compartments in mammalian cells.	Iron	117-121	iron-sulfur cluster assembly enzyme	Homo sapiens	29-33
11079464-5	2000	We have proposed the hypothesis that monomeric iron salts can be safely administered by the parenteral route if iron is tightly complexed to the ligand, thereby causing clinically insignificant release of free iron, and the kinetic properties of the compound allow rapid transfer of iron to plasma transferrin.	Iron	47-51	transferrin	Homo sapiens	298-309
11054110-0	2000	Interferon-gamma and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages.	Iron	101-105	interferon gamma	Mus musculus	0-16
11054110-2	2000	Here we describe the effect of the inflammatory mediators interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) on the expression of Nramp2 mRNA and Fe uptake by cells of the macrophage lineage.	Iron	153-155	interferon gamma	Mus musculus	58-74
11054110-2	2000	Here we describe the effect of the inflammatory mediators interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) on the expression of Nramp2 mRNA and Fe uptake by cells of the macrophage lineage.	Iron	153-155	interferon gamma	Mus musculus	76-85
11029429-0	2000	The mammalian neuroendocrine hormone norepinephrine supplies iron for bacterial growth in the presence of transferrin or lactoferrin.	Iron	61-65	transferrin	Homo sapiens	106-117
11029429-3	2000	Since bacteriostasis by serum is primarily due to the iron-withholding capacity of transferrin, we considered the possibility that norepinephrine can overcome this effect by supplying transferrin-bound iron for growth.	Iron	54-58	transferrin	Homo sapiens	83-94
11029429-3	2000	Since bacteriostasis by serum is primarily due to the iron-withholding capacity of transferrin, we considered the possibility that norepinephrine can overcome this effect by supplying transferrin-bound iron for growth.	Iron	202-206	transferrin	Homo sapiens	184-195
11029429-9	2000	Norepinephrine-stimulated growth in medium containing (55)Fe complexed with transferrin or lactoferrin resulted in uptake of radioactivity by bacterial cells.	Iron	58-60	transferrin	Homo sapiens	76-87
11079464-5	2000	We have proposed the hypothesis that monomeric iron salts can be safely administered by the parenteral route if iron is tightly complexed to the ligand, thereby causing clinically insignificant release of free iron, and the kinetic properties of the compound allow rapid transfer of iron to plasma transferrin.	Iron	112-116	transferrin	Homo sapiens	298-309
11079464-5	2000	We have proposed the hypothesis that monomeric iron salts can be safely administered by the parenteral route if iron is tightly complexed to the ligand, thereby causing clinically insignificant release of free iron, and the kinetic properties of the compound allow rapid transfer of iron to plasma transferrin.	Iron	112-116	transferrin	Homo sapiens	298-309
11079464-5	2000	We have proposed the hypothesis that monomeric iron salts can be safely administered by the parenteral route if iron is tightly complexed to the ligand, thereby causing clinically insignificant release of free iron, and the kinetic properties of the compound allow rapid transfer of iron to plasma transferrin.	Iron	112-116	transferrin	Homo sapiens	298-309
11225250-6	2000	RESULT: Serum TNF alpha or IFN-gamma in RA and RA with ACD patients were higher than those in normal controls, and were inversely correlated with hemoglobin, and serum iron levels.	Iron	168-172	tumor necrosis factor	Homo sapiens	14-23
11032887-3	2000	Aconitase was reactivated upon incubation of cellular extracts with iron and sulfur, suggesting that Abeta causes the release of iron from 4Fe-4S clusters.	Iron	68-72	amyloid beta precursor protein	Homo sapiens	101-106
11032887-3	2000	Aconitase was reactivated upon incubation of cellular extracts with iron and sulfur, suggesting that Abeta causes the release of iron from 4Fe-4S clusters.	Iron	129-133	amyloid beta precursor protein	Homo sapiens	101-106
11071957-0	2000	Intravenous administration of iron in epoetin-treated haemodialysis patients--which drugs, which regimen?	Iron	30-34	erythropoietin	Homo sapiens	38-45
11071973-5	2000	iron preparations could result in iron release into plasma in amounts exceeding the iron binding capacity of transferrin.	Iron	0-4	transferrin	Homo sapiens	109-120
11071973-10	2000	RESULTS: The iron saccharate injection resulted in full transferrin saturation and appearance of BDI in the serum in seven out of the 12 patients.	Iron	13-17	transferrin	Homo sapiens	56-67
11071973-14	2000	Iron saccharate, added to serum in vitro, released only little iron and promoted only slow bacterial growth, but caused falsely high transferrin saturation by one routinely used serum iron assay.	Iron	0-4	transferrin	Homo sapiens	133-144
11071973-14	2000	Iron saccharate, added to serum in vitro, released only little iron and promoted only slow bacterial growth, but caused falsely high transferrin saturation by one routinely used serum iron assay.	Iron	184-188	transferrin	Homo sapiens	133-144
11071973-15	2000	CONCLUSIONS: The results indicate that 100 mg of iron saccharate often leads to transferrin oversaturation and the presence of catalytically active iron within 3.5 h after i.v.	Iron	49-53	transferrin	Homo sapiens	80-91
11095930-3	2000	The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) for incorporation into transferrin.	Iron	61-65	transferrin	Homo sapiens	140-151
11392783-0	2000	[Concentration of transferrin iron and transferrin saturation in blood].	Iron	30-34	transferrin	Homo sapiens	18-29
11392783-1	2000	Transferrin iron, transferrin protein concentrations, and transferrin saturation have been determined for the first time in the whole blood.	Iron	12-16	transferrin	Homo sapiens	0-11
11392783-4	2000	At increased transferrin iron concentration the difference between experimental and reference data sets determined in the blood and plasma was statistically significant in contrast to data sets determined in serum.	Iron	25-29	transferrin	Homo sapiens	13-24
11392783-5	2000	Therefore, the analysis of the blood microsamples ensured an adequate estimation of transferrin iron concentration, especially at high transferrin saturation.	Iron	96-100	transferrin	Homo sapiens	84-95
11392783-6	2000	A new index--transferrin iron concentration in the formed blood elements--was introduced.	Iron	25-29	transferrin	Homo sapiens	13-24
11046093-3	2000	Human insulin was conjugated at a 1:1 molar ratio to iron-loaded human Tf by a disulfide linkage.	Iron	53-57	insulin	Homo sapiens	6-13
11096344-2	2000	The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron.	Iron	238-242	transferrin	Homo sapiens	50-61
11216557-1	2000	OBJECTIVE: Iron supplementation plays a major role in erythropoietin-treated end-stage renal disease patients.	Iron	11-15	erythropoietin	Homo sapiens	54-68
10906140-0	2000	On the Ca2+ dependence of non-transferrin-bound iron uptake in PC12 cells.	Iron	48-52	transferrin	Rattus norvegicus	30-41
10906140-1	2000	Non-transferrin-bound iron (NTBI) uptake has been reported to follow two pathways, Ca(2+)-dependent and Ca(2+)-independent (Wright, T. L., Brissot, P., Ma, W. L., and Weisiger, R. A.	Iron	22-26	transferrin	Rattus norvegicus	4-15
10930410-10	2000	The iron uptake resulting from expression of Smf1p and Smf2p was analyzed in a mutant in which its iron transporters FET3 and FET4 were inactivated.	Iron	4-8	divalent metal ion transporter SMF2	Saccharomyces cerevisiae S288C	55-60
11225250-6	2000	RESULT: Serum TNF alpha or IFN-gamma in RA and RA with ACD patients were higher than those in normal controls, and were inversely correlated with hemoglobin, and serum iron levels.	Iron	168-172	interferon gamma	Homo sapiens	27-36
11023834-5	2000	Copper is a non-competitive inhibitor of (55)Fe uptake through Fet4p (K(i)=22 microM).	Iron	45-47	Fet4p	Saccharomyces cerevisiae S288C	63-68
11042382-0	2000	Differed preferential iron-binding lobe in human transferrin depending on the presence of bicarbonate detected by HPLC/high-resolution inductively coupled plasma mass spectrometry.	Iron	22-26	transferrin	Homo sapiens	49-60
11042382-1	2000	The binding of iron (Fe) to human serum transferrin (Tf) was analyzed with an HPLC system equipped with an anion exchange column and directly connected with a high-resolution inductively coupled plasma mass spectrometer for metal detection.	Iron	15-19	transferrin	Homo sapiens	40-51
11042382-1	2000	The binding of iron (Fe) to human serum transferrin (Tf) was analyzed with an HPLC system equipped with an anion exchange column and directly connected with a high-resolution inductively coupled plasma mass spectrometer for metal detection.	Iron	15-19	transferrin	Homo sapiens	53-55
11042382-1	2000	The binding of iron (Fe) to human serum transferrin (Tf) was analyzed with an HPLC system equipped with an anion exchange column and directly connected with a high-resolution inductively coupled plasma mass spectrometer for metal detection.	Iron	21-23	transferrin	Homo sapiens	40-51
11042382-1	2000	The binding of iron (Fe) to human serum transferrin (Tf) was analyzed with an HPLC system equipped with an anion exchange column and directly connected with a high-resolution inductively coupled plasma mass spectrometer for metal detection.	Iron	21-23	transferrin	Homo sapiens	53-55
11042382-4	2000	When Fe was added as Fe-citrate stepwise to an apo-Tf solution in the presence of bicarbonate, the N-lobe site was the preferential Fe-binding site, while the C-lobe site was preferred in the absence of bicarbonate.	Iron	5-7	transferrin	Homo sapiens	51-53
11042382-5	2000	In both cases, the Fe-peak areas of the preferential site and Fe(2)-Tf increased up to an Fe/Tf molar ratio of 1, and then the peak area of the monoferric Tf decreased while the peak area of Fe(2)-Tf increased.	Iron	19-21	transferrin	Homo sapiens	93-95
11042382-5	2000	In both cases, the Fe-peak areas of the preferential site and Fe(2)-Tf increased up to an Fe/Tf molar ratio of 1, and then the peak area of the monoferric Tf decreased while the peak area of Fe(2)-Tf increased.	Iron	19-21	transferrin	Homo sapiens	93-95
11042382-5	2000	In both cases, the Fe-peak areas of the preferential site and Fe(2)-Tf increased up to an Fe/Tf molar ratio of 1, and then the peak area of the monoferric Tf decreased while the peak area of Fe(2)-Tf increased.	Iron	19-21	transferrin	Homo sapiens	93-95
11042382-6	2000	When the Fe/Tf molar ratio was below 1, the amount of Fe bound to the lobe with a weaker affinity was higher in Fe(2)-Tf than in the monoferric Tf in each case.	Iron	9-11	transferrin	Homo sapiens	12-14
11042382-6	2000	When the Fe/Tf molar ratio was below 1, the amount of Fe bound to the lobe with a weaker affinity was higher in Fe(2)-Tf than in the monoferric Tf in each case.	Iron	9-11	transferrin	Homo sapiens	118-120
11042382-6	2000	When the Fe/Tf molar ratio was below 1, the amount of Fe bound to the lobe with a weaker affinity was higher in Fe(2)-Tf than in the monoferric Tf in each case.	Iron	9-11	transferrin	Homo sapiens	118-120
11023790-11	2000	The breaking of the interdomain H-bond upon protonation can trigger the opening of the iron cleft, facilitating iron loss in serum transferrin and ovotransferrin.	Iron	87-91	serotransferrin	Bos taurus	131-142
11042382-7	2000	Namely, Fe(2)-Tf was the preferential binding state of Fe to human serum Tf.	Iron	8-10	transferrin	Homo sapiens	14-16
11023834-8	2000	Mutant forms of Fet4p that exhibited decreased efficiency in (55/59)Fe uptake were similarly compromised in (67)Cu uptake, indicating that similar amino acid residues in Fet4p contribute to both uptake processes.	Iron	16-18	Fet4p	Saccharomyces cerevisiae S288C	170-175
11042382-7	2000	Namely, Fe(2)-Tf was the preferential binding state of Fe to human serum Tf.	Iron	8-10	transferrin	Homo sapiens	73-75
11053782-4	2000	With electron paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron (Fe-MGD), we directly detected NO&amp;z.rad; from purified NOS in the absence of SOD (Xia et al., PNAS 94:12705, 1997).	Iron	99-101	superoxide dismutase 1	Homo sapiens	179-182
11023834-10	2000	This was shown by the Fet4p-dependence of copper activation of Fet3p, the copper oxidase that supports high affinity iron uptake in yeast.	Iron	117-121	Fet4p	Saccharomyces cerevisiae S288C	22-27
11045759-5	2000	Iron overload as seen in hereditary hemochromatosis patients enhances suppressor T-cell (CD8) numbers and activity, decreases the proliferative capacity, numbers, and activity of helper T cells (CD4) with increases in CD8/CD4 ratios, impairs the generation of cytotoxic T cells, and alters immunoglobulin secretion when compared to treated hereditary hemochromatosis patients or controls.	Iron	0-4	CD4 molecule	Homo sapiens	195-198
10889193-1	2000	Intracellular iron homeostasis is regulated, in part, by interactions between iron-regulatory proteins (IRP1 and IRP2) and iron-responsive elements (IREs) in ferritin and transferrin receptor mRNAs.	Iron	78-82	transferrin	Rattus norvegicus	171-182
10889193-1	2000	Intracellular iron homeostasis is regulated, in part, by interactions between iron-regulatory proteins (IRP1 and IRP2) and iron-responsive elements (IREs) in ferritin and transferrin receptor mRNAs.	Iron	14-18	transferrin	Rattus norvegicus	171-182
11083369-4	2000	The transferrin receptor/ferritin ratio increased significantly in girls but not in boys, indicating insufficient iron stores in the 17-y-old girls in relation to erythropoiesis and iron needs.	Iron	182-186	transferrin	Homo sapiens	4-15
11083370-1	2000	UNLABELLED: Soluble transferrin receptor (sTfR) is a new diagnostic tool for determining iron status and erythropoietic activity.	Iron	89-93	transferrin	Homo sapiens	20-31
11045759-5	2000	Iron overload as seen in hereditary hemochromatosis patients enhances suppressor T-cell (CD8) numbers and activity, decreases the proliferative capacity, numbers, and activity of helper T cells (CD4) with increases in CD8/CD4 ratios, impairs the generation of cytotoxic T cells, and alters immunoglobulin secretion when compared to treated hereditary hemochromatosis patients or controls.	Iron	0-4	CD4 molecule	Homo sapiens	222-225
11045759-7	2000	Iron overload, with its associated increases of serum iron levels and transferrin saturation, may cause a poor response to interferon therapy.	Iron	0-4	transferrin	Homo sapiens	70-81
11017929-11	2000	In the population at risk of African iron overload, only serum iron:TF ratio was consistently significantly lower in TF CD phenotypes (P &lt;0.05).	Iron	63-67	transferrin	Homo sapiens	68-70
11097467-1	2000	The copper-binding protein ceruloplasmin oxidizes ferrous iron to ferric iron, an action that is critical for the binding of iron to transferrin in plasma.	Iron	58-62	transferrin	Homo sapiens	133-144
11097467-1	2000	The copper-binding protein ceruloplasmin oxidizes ferrous iron to ferric iron, an action that is critical for the binding of iron to transferrin in plasma.	Iron	50-62	transferrin	Homo sapiens	133-144
11017929-0	2000	Transferrin polymorphism influences iron status in blacks.	Iron	36-40	transferrin	Homo sapiens	0-11
11017929-9	2000	In the reference population, male TF CD heterozygotes had significantly lower (P &lt;0.01) values for serum iron, TIBC, TF saturation, and serum iron:TF ratio than the TF CC homozygotes; in females, only TIBC was significantly different.	Iron	108-112	transferrin	Homo sapiens	34-36
11017929-9	2000	In the reference population, male TF CD heterozygotes had significantly lower (P &lt;0.01) values for serum iron, TIBC, TF saturation, and serum iron:TF ratio than the TF CC homozygotes; in females, only TIBC was significantly different.	Iron	145-149	transferrin	Homo sapiens	34-36
11017929-11	2000	In the population at risk of African iron overload, only serum iron:TF ratio was consistently significantly lower in TF CD phenotypes (P &lt;0.05).	Iron	63-67	transferrin	Homo sapiens	117-119
11017929-12	2000	After equilibrium dialysis, the amount of iron bound by TF was significantly lower (P &lt;0.01) in TF CD individuals.	Iron	42-46	transferrin	Homo sapiens	56-58
11017929-12	2000	After equilibrium dialysis, the amount of iron bound by TF was significantly lower (P &lt;0.01) in TF CD individuals.	Iron	42-46	transferrin	Homo sapiens	99-101
11017940-0	2000	The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males.	Iron	55-59	haptoglobin	Homo sapiens	4-15
11126152-0	2000	Clinical characteristic of parenteral iron supplementation in hemodialysis patients receiving erythropoietin therapy.	Iron	38-42	erythropoietin	Homo sapiens	94-108
11126152-1	2000	BACKGROUND: Iron deficiency constitutes the major cause of erythropoietin hyporesponse in uremic patients receiving erythropoietin therapy; therefore, iron supplementation is necessary for these patients.	Iron	12-16	erythropoietin	Homo sapiens	59-73
11017940-2	2000	We hypothesized that the genetic polymorphism of haptoglobin (Hp), a hemoglobin-binding plasma protein, could affect iron status.	Iron	117-121	haptoglobin	Homo sapiens	49-60
11126152-1	2000	BACKGROUND: Iron deficiency constitutes the major cause of erythropoietin hyporesponse in uremic patients receiving erythropoietin therapy; therefore, iron supplementation is necessary for these patients.	Iron	12-16	erythropoietin	Homo sapiens	116-130
11126152-13	2000	CONCLUSION: In this study, we found that a large single dose as well as small multiple doses of parenteral iron therapy had similar effects in correcting the iron deficiency in hemodialysis patients treated with erythropoietin.	Iron	107-111	erythropoietin	Homo sapiens	212-226
11122264-2	2000	Serum ferritin and/or soluble transferrin receptor levels can be used to evaluate iron status but are not practical for routinely screening blood donors prior to donation.	Iron	82-86	transferrin	Homo sapiens	30-41
11196670-2	2000	The recent finding that a physical interaction between HFE and transferrin receptor establishes a functional link between HFE and transferrin receptor-mediated iron metabolism in the pathophysiology of hereditary hemochromatosis.	Iron	160-164	transferrin	Homo sapiens	63-74
11196670-2	2000	The recent finding that a physical interaction between HFE and transferrin receptor establishes a functional link between HFE and transferrin receptor-mediated iron metabolism in the pathophysiology of hereditary hemochromatosis.	Iron	160-164	transferrin	Homo sapiens	130-141
11196670-8	2000	Taken together, these results suggest that HFE negatively modulates cellular iron uptake by impairing transferrin receptor endocytosis via HFE-induced receptor phosphorylation.	Iron	77-81	transferrin	Homo sapiens	102-113
10970808-0	2000	The chloride effect is related to anion binding in determining the rate of iron release from the human transferrin N-lobe.	Iron	75-79	transferrin	Homo sapiens	103-114
11344609-1	2000	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Iron	44-48	transferrin	Homo sapiens	66-77
11344609-1	2000	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Iron	44-48	transferrin	Homo sapiens	79-81
11085653-4	2000	Saturation transfer between methyls on adjacent pyrroles in etioheme-reconstituted horse Mb in all accessible oxidation/spin states reveals rotational hopping rates that decrease dramatically with either loss of ligands or reduction of the heme, and correlate qualitatively with expectations based on the Fe-His bond strength and the rate of heme dissociation from Mb.	Iron	305-307	myoglobin	Equus caballus	89-91
11085654-0	2000	Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates.	Iron	16-20	transferrin	Homo sapiens	77-88
11085654-0	2000	Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates.	Iron	44-48	transferrin	Homo sapiens	77-88
11085654-6	2000	All the tested HOPO ligands efficiently remove iron from diferric transferrin at millimolar concentrations, with a hyperbolic dependence on ligand concentration.	Iron	47-51	transferrin	Homo sapiens	66-77
11014998-0	2000	Intravenous low-dose iron administration in hemodialysis patients treated with erythropoietin: 1-year follow-up study.	Iron	21-25	erythropoietin	Homo sapiens	79-93
11005792-3	2000	The rare conditions atransferrinaemia (OMIM 209300) and acaeruloplasminaemia (OMIM 604290), each associated with tissue iron overload, have already implicated the iron transport ligand transferrin and the copper transporter caeruloplasmin in the control of iron homeostasis.	Iron	120-124	transferrin	Homo sapiens	21-32
11005792-3	2000	The rare conditions atransferrinaemia (OMIM 209300) and acaeruloplasminaemia (OMIM 604290), each associated with tissue iron overload, have already implicated the iron transport ligand transferrin and the copper transporter caeruloplasmin in the control of iron homeostasis.	Iron	163-167	transferrin	Homo sapiens	21-32
11005792-3	2000	The rare conditions atransferrinaemia (OMIM 209300) and acaeruloplasminaemia (OMIM 604290), each associated with tissue iron overload, have already implicated the iron transport ligand transferrin and the copper transporter caeruloplasmin in the control of iron homeostasis.	Iron	163-167	transferrin	Homo sapiens	21-32
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	103-107	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	324-336
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	148-152	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	324-336
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	148-152	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	324-336
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	148-152	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	324-336
10996652-0	2000	Interleukin-1beta increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool.	Iron	43-47	interleukin 1 beta	Homo sapiens	0-17
10996652-2	2000	Intracellular iron homeostasis is maintained by the coordinated regulation of ferritin and transferrin receptor synthesis.	Iron	14-18	transferrin	Homo sapiens	91-102
10996652-4	2000	We evaluated the effects of interleukin-1beta (IL-1beta) on iron metabolism in human astrocytoma cells (SW1088).	Iron	60-64	interleukin 1 beta	Homo sapiens	28-45
10996652-4	2000	We evaluated the effects of interleukin-1beta (IL-1beta) on iron metabolism in human astrocytoma cells (SW1088).	Iron	60-64	interleukin 1 beta	Homo sapiens	47-55
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	10-14	interleukin 1 beta	Homo sapiens	116-124
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	82-86	interleukin 1 beta	Homo sapiens	116-124
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	82-86	interleukin 1 beta	Homo sapiens	116-124
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	82-86	interleukin 1 beta	Homo sapiens	116-124
10970808-1	2000	The major function of human transferrin is to deliver iron from the bloodstream to actively dividing cells.	Iron	54-58	transferrin	Homo sapiens	28-39
10970808-3	2000	Extensive studies in vitro indicate that iron release from transferrin is very complex and involves many factors, including pH, the chelator used, an anion effect, temperature, receptor binding and intra-lobe interactions.	Iron	41-45	transferrin	Homo sapiens	59-70
11062761-9	2000	This data suggests that IFN gamma may enhance iron uptake during the early phase of macrophage activation, and in later phases, down-regulate TfR expression by inducing NO, thus contributing to intracellular oxidative stress reduction.	Iron	46-50	interferon gamma	Mus musculus	24-33
11019832-4	2000	Low monooxygenase activity of CYP3A4 was attributed to the insufficient reduction of heme iron of CYP3A4 by NADPH-P450 reductase.	Iron	90-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
10970442-0	2000	Mutation frequency in the lacI gene of liver DNA from lambda/lacI transgenic mice following the interaction of PCBs with iron causing hepatic cancer and porphyria.	Iron	121-125	tissue factor pathway inhibitor	Mus musculus	26-30
11054092-0	2000	Relationship between TNF-alpha and iron metabolism in differentiating human monocytic THP-1 cells.	Iron	35-39	tumor necrosis factor	Homo sapiens	21-30
11054092-3	2000	In addition, we found that iron administration to PMA-differentiating cells induced the expression of TNF-alpha mRNA and TNF-alpha secretion to levels even higher than those induced by IFN-gamma alone.	Iron	27-31	tumor necrosis factor	Homo sapiens	102-111
11054092-3	2000	In addition, we found that iron administration to PMA-differentiating cells induced the expression of TNF-alpha mRNA and TNF-alpha secretion to levels even higher than those induced by IFN-gamma alone.	Iron	27-31	tumor necrosis factor	Homo sapiens	121-130
11054092-4	2000	The iron chelator desferrioxamine showed the opposite effect and reduced TNF-alpha release.	Iron	4-8	tumor necrosis factor	Homo sapiens	73-82
11054092-5	2000	In contrast, preincubation of the cells with iron before PMA induction resulted in a decrease of the TNF-alpha secretion induced by IFN-gamma, whereas the opposite was true after preincubation with desferrioxamine.	Iron	45-49	tumor necrosis factor	Homo sapiens	101-110
11054092-5	2000	In contrast, preincubation of the cells with iron before PMA induction resulted in a decrease of the TNF-alpha secretion induced by IFN-gamma, whereas the opposite was true after preincubation with desferrioxamine.	Iron	45-49	interferon gamma	Homo sapiens	132-141
11054092-6	2000	The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages.	Iron	51-55	tumor necrosis factor	Homo sapiens	133-142
11054092-6	2000	The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages.	Iron	103-107	tumor necrosis factor	Homo sapiens	60-69
11054092-6	2000	The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages.	Iron	103-107	tumor necrosis factor	Homo sapiens	133-142
11054092-6	2000	The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages.	Iron	103-107	tumor necrosis factor	Homo sapiens	60-69
11054092-6	2000	The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages.	Iron	103-107	tumor necrosis factor	Homo sapiens	133-142
11020014-0	2000	HFE mutations in insulin resistance-associated hepatic iron overload.	Iron	55-59	insulin	Homo sapiens	17-24
10985917-1	2000	Iron loading in hemochromatosis attains extremely high levels and is accompanied by many signs (ferritin &gt;300 microg/l, hematocrit &gt;50%, transferrin saturation &gt;70%, etc.).	Iron	0-4	transferrin	Homo sapiens	143-154
10985917-4	2000	I postulate a mechanism, by which a cell can continue to express transferrin receptors, without producing ferritin, even when it is saturated with iron.	Iron	147-151	transferrin	Homo sapiens	65-76
10985917-5	2000	Furthermore, I suggest that this silent iron loading, induced by cadmium and other metals, plays an important role in many degenerative diseases involving free radicals, DNA damage and peroxynitrite, all of which are intimately linked to iron.Moreover, since ferritin, transferrin saturation and hematocrit levels are not directly related to cellular iron levels, and since excess iron can wreak havoc in the cell, we can conclude that there is a need for a better way to evaluate intracellular iron levels and especially the intracellular free iron levels by a non-invasive technique.Finally, phlebotomy is suggested as the best way to reduce Fe and Mo stores, and chelation with succimer is recommended in order to eliminate Cd.	Iron	40-44	transferrin	Homo sapiens	269-280
10985917-5	2000	Furthermore, I suggest that this silent iron loading, induced by cadmium and other metals, plays an important role in many degenerative diseases involving free radicals, DNA damage and peroxynitrite, all of which are intimately linked to iron.Moreover, since ferritin, transferrin saturation and hematocrit levels are not directly related to cellular iron levels, and since excess iron can wreak havoc in the cell, we can conclude that there is a need for a better way to evaluate intracellular iron levels and especially the intracellular free iron levels by a non-invasive technique.Finally, phlebotomy is suggested as the best way to reduce Fe and Mo stores, and chelation with succimer is recommended in order to eliminate Cd.	Iron	238-242	transferrin	Homo sapiens	269-280
10985917-5	2000	Furthermore, I suggest that this silent iron loading, induced by cadmium and other metals, plays an important role in many degenerative diseases involving free radicals, DNA damage and peroxynitrite, all of which are intimately linked to iron.Moreover, since ferritin, transferrin saturation and hematocrit levels are not directly related to cellular iron levels, and since excess iron can wreak havoc in the cell, we can conclude that there is a need for a better way to evaluate intracellular iron levels and especially the intracellular free iron levels by a non-invasive technique.Finally, phlebotomy is suggested as the best way to reduce Fe and Mo stores, and chelation with succimer is recommended in order to eliminate Cd.	Iron	238-242	transferrin	Homo sapiens	269-280
10985917-5	2000	Furthermore, I suggest that this silent iron loading, induced by cadmium and other metals, plays an important role in many degenerative diseases involving free radicals, DNA damage and peroxynitrite, all of which are intimately linked to iron.Moreover, since ferritin, transferrin saturation and hematocrit levels are not directly related to cellular iron levels, and since excess iron can wreak havoc in the cell, we can conclude that there is a need for a better way to evaluate intracellular iron levels and especially the intracellular free iron levels by a non-invasive technique.Finally, phlebotomy is suggested as the best way to reduce Fe and Mo stores, and chelation with succimer is recommended in order to eliminate Cd.	Iron	238-242	transferrin	Homo sapiens	269-280
10985917-5	2000	Furthermore, I suggest that this silent iron loading, induced by cadmium and other metals, plays an important role in many degenerative diseases involving free radicals, DNA damage and peroxynitrite, all of which are intimately linked to iron.Moreover, since ferritin, transferrin saturation and hematocrit levels are not directly related to cellular iron levels, and since excess iron can wreak havoc in the cell, we can conclude that there is a need for a better way to evaluate intracellular iron levels and especially the intracellular free iron levels by a non-invasive technique.Finally, phlebotomy is suggested as the best way to reduce Fe and Mo stores, and chelation with succimer is recommended in order to eliminate Cd.	Iron	238-242	transferrin	Homo sapiens	269-280
10985917-5	2000	Furthermore, I suggest that this silent iron loading, induced by cadmium and other metals, plays an important role in many degenerative diseases involving free radicals, DNA damage and peroxynitrite, all of which are intimately linked to iron.Moreover, since ferritin, transferrin saturation and hematocrit levels are not directly related to cellular iron levels, and since excess iron can wreak havoc in the cell, we can conclude that there is a need for a better way to evaluate intracellular iron levels and especially the intracellular free iron levels by a non-invasive technique.Finally, phlebotomy is suggested as the best way to reduce Fe and Mo stores, and chelation with succimer is recommended in order to eliminate Cd.	Iron	238-242	transferrin	Homo sapiens	269-280
10985917-5	2000	Furthermore, I suggest that this silent iron loading, induced by cadmium and other metals, plays an important role in many degenerative diseases involving free radicals, DNA damage and peroxynitrite, all of which are intimately linked to iron.Moreover, since ferritin, transferrin saturation and hematocrit levels are not directly related to cellular iron levels, and since excess iron can wreak havoc in the cell, we can conclude that there is a need for a better way to evaluate intracellular iron levels and especially the intracellular free iron levels by a non-invasive technique.Finally, phlebotomy is suggested as the best way to reduce Fe and Mo stores, and chelation with succimer is recommended in order to eliminate Cd.	Iron	644-646	transferrin	Homo sapiens	269-280
11227366-1	2000	Role of iron in the treatment with erythropoietin].	Iron	8-12	erythropoietin	Homo sapiens	35-49
11227366-3	2000	An optimal Hb level with the lowest dosage of EPO seams to be correlated to the way of administration and an adequate iron supplementation.	Iron	118-122	erythropoietin	Homo sapiens	46-49
11227366-4	2000	METHODS: The study evaluates the influence of iron supplementation on the control of EPO-related expenses.	Iron	46-50	erythropoietin	Homo sapiens	85-88
11227366-8	2000	iron supplementation correlates with a significant raise of serum ferritin level and saves on EPO-related expenses up to 1 million/per patient/per year.	Iron	0-4	erythropoietin	Homo sapiens	94-97
10984552-6	2000	In the human cell lines, Caco-2 (small intestinal phenotype upon differentiation) and K562 (erythroleukaemic) HFE, in the presence of iron-saturated transferrin, co-localized with transferrin receptors in an early endosome compartment using confocal immunofluorescence microscopy.	Iron	134-138	transferrin	Homo sapiens	149-160
10984552-6	2000	In the human cell lines, Caco-2 (small intestinal phenotype upon differentiation) and K562 (erythroleukaemic) HFE, in the presence of iron-saturated transferrin, co-localized with transferrin receptors in an early endosome compartment using confocal immunofluorescence microscopy.	Iron	134-138	transferrin	Homo sapiens	180-191
10984552-9	2000	Disruption of the HFE gene as a result of mutations associated with hereditary haemochromatosis may thus impair homeostatic mechanisms controlling iron absorption within the small-intestine epithelium by a direct interaction with transferrin receptors and by subsequent alteration of DMT-1 expression.	Iron	147-151	transferrin	Homo sapiens	230-241
10833524-3	2000	This had no evident effect in the mutant ferritin clone, whereas it induced an iron-deficient phenotype in the H-ferritin wild type clone, manifested by approximately 5-fold increase of IRPs activity, approximately 2.5-fold increase of transferrin receptor, approximately 1.8-fold increase in iron-transferrin iron uptake, and approximately 50% reduction of labile iron pool.	Iron	79-83	transferrin	Homo sapiens	236-247
10956045-10	2000	The X-ray absorption data reveal that iron in ferric cystathionine beta-synthase is 6-coordinate, with 1 high-Z scatterer and 5 low-Z scatterers.	Iron	38-42	cystathionine beta-synthase	Homo sapiens	53-80
10833524-3	2000	This had no evident effect in the mutant ferritin clone, whereas it induced an iron-deficient phenotype in the H-ferritin wild type clone, manifested by approximately 5-fold increase of IRPs activity, approximately 2.5-fold increase of transferrin receptor, approximately 1.8-fold increase in iron-transferrin iron uptake, and approximately 50% reduction of labile iron pool.	Iron	79-83	transferrin	Homo sapiens	298-309
10942406-12	2000	These results suggest that the lipophilic epolones might induce HIF-1 alpha by intracellular iron chelation.	Iron	93-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-75
10931525-1	2000	Transferrin, the iron-transport protein of vertebrate serum, is synthesized mainly in the liver, from which it is secreted into the blood.	Iron	17-21	transferrin	Homo sapiens	0-11
10934140-0	2000	Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.	Iron	29-33	amyloid beta precursor protein	Homo sapiens	75-88
10970537-0	2000	Self-limiting growth of metal fluoride thin films by oxidation reactions employing molecular precursors FeF (2) films are grown by the reaction of XeF (2) and SeF (6) with iron foil.	Iron	172-176	interleukin 17 receptor D	Homo sapiens	159-162
10961657-1	2000	Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes the rate-limiting step in the degradation of heme to biliverdin, carbon monoxide and iron, and its expression can be used as a marker for oxidative stress.	Iron	147-151	heme oxygenase 1	Mus musculus	0-16
10961657-1	2000	Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes the rate-limiting step in the degradation of heme to biliverdin, carbon monoxide and iron, and its expression can be used as a marker for oxidative stress.	Iron	147-151	heme oxygenase 1	Mus musculus	18-22
10911382-14	2000	In non-intestinal cells most iron uptake occurs via either the classical clathrin-coated pathway utilizing transferrin receptors or the poorly defined transferrin receptor independent pathway.	Iron	29-33	transferrin	Homo sapiens	107-118
10911382-14	2000	In non-intestinal cells most iron uptake occurs via either the classical clathrin-coated pathway utilizing transferrin receptors or the poorly defined transferrin receptor independent pathway.	Iron	29-33	transferrin	Homo sapiens	151-162
10963781-1	2000	Transferrin is a N-glycosylated glycoprotein and plays an important role in iron transport from sites of absorption and storage to sites of utilization.	Iron	76-80	transferrin	Homo sapiens	0-11
10934140-1	2000	Neurodegeneration with brain iron accumulation, type 1 (NBIA 1), or Hallervorden-Spatz syndrome, is a rare neurodegenerative disorder characterized clinically by Parkinsonism, cognitive impairment, pseudobulbar features, as well as cerebellar ataxia, and neuropathologically by neuronal loss, gliosis, and iron deposition in the globus pallidus, red nucleus, and substantia nigra.	Iron	29-33	pantothenate kinase 2	Homo sapiens	56-62
10934140-1	2000	Neurodegeneration with brain iron accumulation, type 1 (NBIA 1), or Hallervorden-Spatz syndrome, is a rare neurodegenerative disorder characterized clinically by Parkinsonism, cognitive impairment, pseudobulbar features, as well as cerebellar ataxia, and neuropathologically by neuronal loss, gliosis, and iron deposition in the globus pallidus, red nucleus, and substantia nigra.	Iron	29-33	amyloid beta precursor protein	Homo sapiens	12-13
10934140-1	2000	Neurodegeneration with brain iron accumulation, type 1 (NBIA 1), or Hallervorden-Spatz syndrome, is a rare neurodegenerative disorder characterized clinically by Parkinsonism, cognitive impairment, pseudobulbar features, as well as cerebellar ataxia, and neuropathologically by neuronal loss, gliosis, and iron deposition in the globus pallidus, red nucleus, and substantia nigra.	Iron	306-310	pantothenate kinase 2	Homo sapiens	56-62
10934140-1	2000	Neurodegeneration with brain iron accumulation, type 1 (NBIA 1), or Hallervorden-Spatz syndrome, is a rare neurodegenerative disorder characterized clinically by Parkinsonism, cognitive impairment, pseudobulbar features, as well as cerebellar ataxia, and neuropathologically by neuronal loss, gliosis, and iron deposition in the globus pallidus, red nucleus, and substantia nigra.	Iron	306-310	amyloid beta precursor protein	Homo sapiens	12-13
10967511-9	2000	Furthermore, the enhancement of erythropoiesis by EPO makes it mandatory to administer oral or intravenous iron supplementation during therapy to meet the increased demand.	Iron	107-111	erythropoietin	Homo sapiens	50-53
10910892-2	2000	Under conditions of significant blood loss, erythropoietin therapy, or both, iron-restricted erythropoiesis is evident, even in the presence of storage iron and iron oral supplementation.	Iron	77-81	erythropoietin	Homo sapiens	44-58
10910892-3	2000	Intravenous iron therapy in renal dialysis patients undergoing erythropoietin therapy can produce hematologic responses with serum ferritin levels up to 400 microg/L, indicating that traditional biochemical markers of storage iron in patients with anemia caused by chronic disease are unhelpful in the assessment of iron status.	Iron	12-16	erythropoietin	Homo sapiens	63-77
10910892-6	2000	The availability of safer intravenous iron preparations allows for carefully controlled studies of their value in patients undergoing erythropoietin therapy or experiencing blood loss, or both.	Iron	38-42	erythropoietin	Homo sapiens	134-148
10910932-0	2000	Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.	Iron	45-49	transferrin	Homo sapiens	33-44
10891064-0	2000	IscU as a scaffold for iron-sulfur cluster biosynthesis: sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU.	Iron	23-27	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
10966249-0	2000	Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients.	Iron	31-35	erythropoietin	Homo sapiens	68-82
10966249-9	2000	The EPO group received iv iron and epoetin alfa (300 IU/kg) subcutaneously on days 1, 3, 5, 7, and 9.	Iron	26-30	erythropoietin	Homo sapiens	4-7
10982248-0	2000	Intravenous versus oral iron supplementation for preoperative stimulation of hemoglobin synthesis using recombinant human erythropoietin.	Iron	24-28	erythropoietin	Homo sapiens	122-136
10751401-2	2000	Recently, it has been shown that the microcytic anemia (mk) mouse and the Belgrade (b) rat, which have inherited defects in iron transport that result in iron deficiency anemia, have the same missense mutation (G185R) in Nramp2.	Iron	124-128	solute carrier family 11 member 2	Rattus norvegicus	221-227
10891064-8	2000	In addition, the resonance Raman spectrum of the [4Fe-4S](2+) cluster in IscU is best interpreted in terms of noncysteinyl ligation at a unique Fe site.	Iron	51-53	iron-sulfur cluster assembly enzyme	Homo sapiens	73-77
10942934-5	2000	The patient was successfully iron-depleted by combining phlebotomy with recombinant human erythropoietin.	Iron	29-33	erythropoietin	Homo sapiens	90-104
10899879-0	2000	Antigenic and sequence diversity in gonococcal transferrin-binding protein A. Neisseria gonorrhoeae is a gram-negative pathogen that is capable of satisfying its iron requirement with human iron-binding proteins such as transferrin and lactoferrin.	Iron	162-166	transferrin	Homo sapiens	47-58
10899879-0	2000	Antigenic and sequence diversity in gonococcal transferrin-binding protein A. Neisseria gonorrhoeae is a gram-negative pathogen that is capable of satisfying its iron requirement with human iron-binding proteins such as transferrin and lactoferrin.	Iron	162-166	transferrin	Homo sapiens	220-231
10899879-0	2000	Antigenic and sequence diversity in gonococcal transferrin-binding protein A. Neisseria gonorrhoeae is a gram-negative pathogen that is capable of satisfying its iron requirement with human iron-binding proteins such as transferrin and lactoferrin.	Iron	190-194	transferrin	Homo sapiens	47-58
10899879-0	2000	Antigenic and sequence diversity in gonococcal transferrin-binding protein A. Neisseria gonorrhoeae is a gram-negative pathogen that is capable of satisfying its iron requirement with human iron-binding proteins such as transferrin and lactoferrin.	Iron	190-194	transferrin	Homo sapiens	220-231
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	12-16	transferrin	Homo sapiens	0-11
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	12-16	transferrin	Homo sapiens	64-75
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	12-16	transferrin	Homo sapiens	155-166
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	139-143	transferrin	Homo sapiens	0-11
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	139-143	transferrin	Homo sapiens	64-75
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	139-143	transferrin	Homo sapiens	155-166
10926654-2	2000	One hallmark of HIF-1 responses is that they can be induced by iron chelation.	Iron	63-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
10891064-1	2000	Iron-sulfur cluster biosynthesis in both prokaryotic and eukaryotic cells is known to be mediated by two highly conserved proteins, termed IscS and IscU in prokaryotes.	Iron	0-4	iron-sulfur cluster assembly enzyme	Homo sapiens	148-152
10891064-3	2000	In this work, the time course of IscS-mediated Fe-S cluster assembly in IscU was monitored via anaerobic anion exchange chromatography.	Iron	47-51	iron-sulfur cluster assembly enzyme	Homo sapiens	72-76
10873876-1	2000	Hemodialysis (HD) patients are prone to develop iron deficiency because of consumption of iron stores during erythropoietin (EPO) therapy.	Iron	48-52	erythropoietin	Homo sapiens	109-123
10871590-8	2000	CRP concentrations were notably high in 54% of the anemic women with no nutritional deficiencies and in 73.5% of the anemic women who were iron replete by bone marrow assessment.	Iron	139-143	C-reactive protein	Homo sapiens	0-3
10873876-1	2000	Hemodialysis (HD) patients are prone to develop iron deficiency because of consumption of iron stores during erythropoietin (EPO) therapy.	Iron	48-52	erythropoietin	Homo sapiens	125-128
10945571-8	2000	Transferrin iron binding capacity tended to be higher in the CVD group (P = 0.088).	Iron	12-16	transferrin	Homo sapiens	0-11
10873160-0	2000	Iron is a regulatory component of human IL-1beta production.	Iron	0-4	interleukin 1 beta	Homo sapiens	40-48
10873160-4	2000	Iron has been reported to influence the production of a number of proinflammatory mediators, including human interleukin (IL)-1beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	109-131
10873160-5	2000	We postulated that we could (1) demonstrate regional differences in the release of IL-1beta from human alveolar macrophages and (2) influence the production of IL-1beta in human macrophages by altering intracellular iron concentrations.	Iron	216-220	interleukin 1 beta	Homo sapiens	83-91
10873160-5	2000	We postulated that we could (1) demonstrate regional differences in the release of IL-1beta from human alveolar macrophages and (2) influence the production of IL-1beta in human macrophages by altering intracellular iron concentrations.	Iron	216-220	interleukin 1 beta	Homo sapiens	160-168
10873160-7	2000	Additionally, we established an in vitro model of "iron-loaded" cells of the human myelomonocytic cell line THP-1 in order to examine more directly the effect of iron and its chelation on the secretion of IL-1beta.	Iron	51-55	GLI family zinc finger 2	Homo sapiens	108-113
10873160-7	2000	Additionally, we established an in vitro model of "iron-loaded" cells of the human myelomonocytic cell line THP-1 in order to examine more directly the effect of iron and its chelation on the secretion of IL-1beta.	Iron	51-55	interleukin 1 beta	Homo sapiens	205-213
10873160-7	2000	Additionally, we established an in vitro model of "iron-loaded" cells of the human myelomonocytic cell line THP-1 in order to examine more directly the effect of iron and its chelation on the secretion of IL-1beta.	Iron	162-166	interleukin 1 beta	Homo sapiens	205-213
10873160-8	2000	We report here that an intracellular, chelatable pool of iron expands with exogenous iron-loading as well as with lipopolysaccharide (LPS) stimulation and appears to suppress transcription of IL-1beta, whereas shrinkage of this pool by early chelation augments transcription of IL-1beta beyond that induced by LPS alone.	Iron	57-61	interleukin 1 beta	Homo sapiens	192-200
10873160-8	2000	We report here that an intracellular, chelatable pool of iron expands with exogenous iron-loading as well as with lipopolysaccharide (LPS) stimulation and appears to suppress transcription of IL-1beta, whereas shrinkage of this pool by early chelation augments transcription of IL-1beta beyond that induced by LPS alone.	Iron	57-61	interleukin 1 beta	Homo sapiens	278-286
10873160-9	2000	And finally, we demonstrate a regional relationship in the lung between excess alveolar iron and the production of human alveolar macrophage-derived IL-1beta, suggesting a partnership between iron and inflammation that may have clinical significance, especially in relation to lung diseases with a regional predominance.	Iron	88-92	interleukin 1 beta	Homo sapiens	149-157
10873160-9	2000	And finally, we demonstrate a regional relationship in the lung between excess alveolar iron and the production of human alveolar macrophage-derived IL-1beta, suggesting a partnership between iron and inflammation that may have clinical significance, especially in relation to lung diseases with a regional predominance.	Iron	192-196	interleukin 1 beta	Homo sapiens	149-157
11059064-5	2000	The patient had the typical biochemical abnormalities of iron overload: transferrin saturation index of 53.1% and elevated serum ferritin (658 ng/mL).	Iron	57-61	transferrin	Homo sapiens	72-83
10945571-11	2000	After adjustment for age and time on dialysis, transferrin iron binding capacity (P = 0.013) and copper (P = 0.019) continued to be associated with CVD risk but ceruloplasmin (P = 0.065) and CRP (P = 0.634) were not.	Iron	59-63	transferrin	Homo sapiens	47-58
10945571-13	2000	In conclusion, copper and transferrin iron binding capacity may be associated with CVD risk in HD subjects.	Iron	38-42	transferrin	Homo sapiens	26-37
10921552-2	2000	Aberrant plasma iron chemistry (increased iron loading of transferrin and/or the presence of redox-active low molecular mass iron) and increased plasma thiol levels are features of this type of surgery and represent a potential pro-oxidant risk for oxidative damage.	Iron	16-20	transferrin	Homo sapiens	58-69
10861241-1	2000	Natural resistance-associated macrophage protein 2 (Nramp2) has been suggested to be involved in transferrin-independent iron uptake.	Iron	121-125	transferrin	Homo sapiens	97-108
10861241-10	2000	However, this transferrin-independent uptake of iron into the cells is not a Ca(2+)-dependent process.	Iron	48-52	transferrin	Homo sapiens	14-25
10861214-2	2000	They display a bimodal behaviour (characterized by an "alkaline" and an "acid" transition), which indicates that (at least) two protonating groups change their pK(b) values upon reduction (and/or oxidation) of the iron atom in haem.	Iron	214-218	AKT serine/threonine kinase 1	Homo sapiens	160-164
11040982-0	2000	[Release of iron ions from transferrin under the effect of nitric oxide].	Iron	12-16	transferrin	Homo sapiens	27-38
11799582-4	2000	The study confirmed the concepts regarding iron therapy expressed in the U.S. NKF-DOQI Clinical Practice Guidelines that hemodialysis patients with serum ferritin below 100 ng/ml or transferrin saturation below 20% need supplementation with parenteral iron in excess of 1000 mg to achieve optimal response in hemoglobin/hematocrit (Hgb/Hct) levels.	Iron	43-47	transferrin	Homo sapiens	182-193
10921552-11	2000	Nonsurviving patients with ARDS secondary to CPB surgery displayed significantly greater levels of aberrant iron chemistry (elevated levels of iron saturation of transferrin) with decreased iron-binding antioxidant protection and elevated plasma thiol levels than did survivors.	Iron	108-112	transferrin	Homo sapiens	162-173
10939448-1	2000	Transferrin, an iron transport protein found in serum and cerebrospinal fluid, is known to be microheterogeneous with respect to its carbohydrate and sialic acid content.	Iron	16-20	transferrin	Homo sapiens	0-11
10866821-2	2000	Our in vitro experiments using synthetic beta-amyloid peptide and glucose or fructose show that formation of covalently cross-linked high-molecular-mass beta-amyloid peptide oligomers is accelerated by micromolar amounts of copper (Cu+, Cu2+) and iron (Fe2+, Fe3+) ions.	Iron	247-251	amyloid beta precursor protein	Homo sapiens	153-173
10959032-3	2000	Abeta converts molecular oxygen into hydrogen peroxide by reducing copper or iron, and this may lead to Fenton chemistry.	Iron	77-81	amyloid beta precursor protein	Homo sapiens	0-5
11044631-0	2000	Changes of transferrin-free iron uptake by bone marrow erythroblasts in strenuously exercised rats.	Iron	28-32	transferrin	Rattus norvegicus	11-22
10845934-0	2000	Constitutive activation of the MAPK pathway mediates v-fes-induced mitogenesis in murine macrophages.	Iron	55-58	mitogen-activated protein kinase 1	Mus musculus	31-35
10801774-1	2000	Abeta binds Zn(2+), Cu(2+), and Fe(3+) in vitro, and these metals are markedly elevated in the neocortex and especially enriched in amyloid plaque deposits of individuals with Alzheimer"s disease (AD).	Iron	32-34	amyloid beta precursor protein	Homo sapiens	0-5
10907637-0	2000	Modulation of transduced erythropoietin expression by iron.	Iron	54-58	erythropoietin	Homo sapiens	25-39
10907637-2	2000	However, other factors such as cytokines or the iron load of erythropoietin-expressing cells can concomitantly modulate transgene expression, as shown for the expression of the endogenous erythropoietin gene in human cell lines and in animals.	Iron	48-52	erythropoietin	Homo sapiens	61-75
10907637-2	2000	However, other factors such as cytokines or the iron load of erythropoietin-expressing cells can concomitantly modulate transgene expression, as shown for the expression of the endogenous erythropoietin gene in human cell lines and in animals.	Iron	48-52	erythropoietin	Homo sapiens	188-202
10907637-7	2000	CONCLUSION: These results show that, in addition to oxygen partial pressure, the intracellular iron content is critical in the modulation of hypoxia-regulated erythropoietin transgene expression.	Iron	95-99	erythropoietin	Homo sapiens	159-173
10828980-1	2000	Lactoferrin (Lf) and serum transferrin (Tf) combine high-affinity iron binding with an ability to release this iron at reduced pH.	Iron	66-70	transferrin	Homo sapiens	27-38
10828980-1	2000	Lactoferrin (Lf) and serum transferrin (Tf) combine high-affinity iron binding with an ability to release this iron at reduced pH.	Iron	66-70	transferrin	Homo sapiens	40-42
10828980-1	2000	Lactoferrin (Lf) and serum transferrin (Tf) combine high-affinity iron binding with an ability to release this iron at reduced pH.	Iron	111-115	transferrin	Homo sapiens	27-38
10828980-1	2000	Lactoferrin (Lf) and serum transferrin (Tf) combine high-affinity iron binding with an ability to release this iron at reduced pH.	Iron	111-115	transferrin	Homo sapiens	40-42
10828980-4	2000	To probe factors intrinsic to the N-lobes, we further examined the specific role of two basic residues that are proposed to form a pH-sensitive dilysine trigger for iron release in the N-lobe of Tf [Dewan, J. C., Mikami, B., Hirose, M., and Sacchettini, J. C. (1993) Biochemistry 32, 11963-11968] by mutating Arg 210 to Lys in the N-lobe half-molecule Lf(N).	Iron	165-169	transferrin	Homo sapiens	195-197
10875444-2	2000	Non-heme iron is abundantly present in the brain in three different forms: "low molecular weight" complexes, iron bound to "medium molecular weight complexes" metalloproteins such as transferrin, and "high molecular weight" complexes as ferritin and hemosiderin.	Iron	9-13	transferrin	Homo sapiens	183-194
10914961-1	2000	UNLABELLED: Serum transferrin receptor (sTfR) concentration reflects functional iron status and erythropoietic activity.	Iron	80-84	transferrin	Homo sapiens	18-29
10806335-1	2000	Lactoferrin, an iron-binding protein of the transferrin family, is a highly basic protein which interacts with many acidic molecules, including heparin proteoglycans.	Iron	16-20	transferrin	Homo sapiens	44-55
11207577-11	2000	We conclude that Neisseria infection alters epithelial cell transferrin-iron homeostasis at multiple levels.	Iron	72-76	transferrin	Homo sapiens	60-71
11207577-0	2000	Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeae.	Iron	42-46	transferrin	Homo sapiens	30-41
11207577-2	2000	In mammals, iron is transported to body tissues by the serum glycoprotein transferrin.	Iron	12-16	transferrin	Homo sapiens	74-85
11207577-3	2000	Transferrin-iron is internalized by binding to specific receptors followed by endocytosis.	Iron	12-16	transferrin	Homo sapiens	0-11
10850644-0	2000	Effects of erythropoietin therapy on iron absorption in chronic renal failure.	Iron	37-41	erythropoietin	Homo sapiens	11-25
11207577-4	2000	In vitro, Neisseria meningitidis and Neisseria gonorrhoeae can use iron from a variety of iron-containing compounds, including human transferrin.	Iron	67-71	transferrin	Homo sapiens	133-144
11207577-4	2000	In vitro, Neisseria meningitidis and Neisseria gonorrhoeae can use iron from a variety of iron-containing compounds, including human transferrin.	Iron	90-94	transferrin	Homo sapiens	133-144
11207577-5	2000	In vivo, transferrin is an important source of iron for N. gonorrhoeae: a mutant that is unable to bind and use transferrin-iron is unable to colonize the urethra of men or initiate disease at this site.	Iron	47-51	transferrin	Homo sapiens	9-20
11207577-5	2000	In vivo, transferrin is an important source of iron for N. gonorrhoeae: a mutant that is unable to bind and use transferrin-iron is unable to colonize the urethra of men or initiate disease at this site.	Iron	124-128	transferrin	Homo sapiens	9-20
11207577-5	2000	In vivo, transferrin is an important source of iron for N. gonorrhoeae: a mutant that is unable to bind and use transferrin-iron is unable to colonize the urethra of men or initiate disease at this site.	Iron	124-128	transferrin	Homo sapiens	112-123
11207577-6	2000	As pathogenic Neisseria and its human host derive much of their iron from transferrin, we reasoned that a competition may exist between microbe and host epithelial cells for transferrin-iron at certain stages of infection.	Iron	186-190	transferrin	Homo sapiens	174-185
11207577-7	2000	We therefore tested the hypothesis that N. meningitidis and N. gonorrhoeae may actively interfere with host transferrin-iron metabolism.	Iron	120-124	transferrin	Homo sapiens	108-119
10849019-0	2000	Iron supplementation affects the production of pro-inflammatory cytokines in IL-10 deficient mice.	Iron	0-4	interleukin 10	Mus musculus	77-82
10849019-8	2000	RESULTS: Oral as well as rectal administration of iron resulted in increased pro-inflammatory cytokine production in IL-10-/- mice.	Iron	50-54	interleukin 10	Mus musculus	117-122
10849019-9	2000	Neutrophil counts in IL10-/- on a high iron diet increased as well.	Iron	39-43	interleukin 10	Mus musculus	21-25
10849019-11	2000	CONCLUSION: We conclude that dietary or topical administered iron increases pro-inflammatory cytokine production in the colon of IL10-/- mice.	Iron	61-65	interleukin 10	Mus musculus	129-133
10921422-5	2000	A similar fall in transferrin-bound plasma iron was also seen.	Iron	43-47	transferrin	Rattus norvegicus	18-29
10921422-10	2000	The similarity in the degree of fall in transferrin-bound iron levels with a change in diet suggests that iron excretion involves the uptake and excretion of transferrin bound-iron, possibly by goblet cells.	Iron	58-62	transferrin	Rattus norvegicus	40-51
10921422-10	2000	The similarity in the degree of fall in transferrin-bound iron levels with a change in diet suggests that iron excretion involves the uptake and excretion of transferrin bound-iron, possibly by goblet cells.	Iron	58-62	transferrin	Rattus norvegicus	158-169
10921422-10	2000	The similarity in the degree of fall in transferrin-bound iron levels with a change in diet suggests that iron excretion involves the uptake and excretion of transferrin bound-iron, possibly by goblet cells.	Iron	106-110	transferrin	Rattus norvegicus	40-51
10921422-10	2000	The similarity in the degree of fall in transferrin-bound iron levels with a change in diet suggests that iron excretion involves the uptake and excretion of transferrin bound-iron, possibly by goblet cells.	Iron	106-110	transferrin	Rattus norvegicus	158-169
10921422-10	2000	The similarity in the degree of fall in transferrin-bound iron levels with a change in diet suggests that iron excretion involves the uptake and excretion of transferrin bound-iron, possibly by goblet cells.	Iron	106-110	transferrin	Rattus norvegicus	40-51
10921422-10	2000	The similarity in the degree of fall in transferrin-bound iron levels with a change in diet suggests that iron excretion involves the uptake and excretion of transferrin bound-iron, possibly by goblet cells.	Iron	106-110	transferrin	Rattus norvegicus	158-169
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	14-18	transferrin	Rattus norvegicus	119-130
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	73-77	transferrin	Rattus norvegicus	119-130
10859223-2	2000	We investigated the uptake of transferrin-bound iron by duodenal enterocytes in Wistar rats fed different levels of iron and Belgrade (b/b) rats in which iron uptake by the transferrin cycle is defective because of a mutation in DMT1.	Iron	48-52	transferrin	Rattus norvegicus	30-41
10859223-4	2000	In all groups the uptake of transferrin-bound iron by crypt cells was directly proportional to plasma iron concentration, being highest in iron-loaded Wistar rats and b/b rats.	Iron	46-50	transferrin	Rattus norvegicus	28-39
10859223-4	2000	In all groups the uptake of transferrin-bound iron by crypt cells was directly proportional to plasma iron concentration, being highest in iron-loaded Wistar rats and b/b rats.	Iron	102-106	transferrin	Rattus norvegicus	28-39
10859223-4	2000	In all groups the uptake of transferrin-bound iron by crypt cells was directly proportional to plasma iron concentration, being highest in iron-loaded Wistar rats and b/b rats.	Iron	102-106	transferrin	Rattus norvegicus	28-39
10859223-5	2000	We conclude that the uptake of transferrin-bound iron by developing enterocytes is largely independent of DMT1.	Iron	49-53	transferrin	Rattus norvegicus	31-42
10850644-1	2000	The effect of erythropoietin administration on the absorption of dietary and therapeutic iron was examined in patients with anemia of chronic renal failure on maintenance hemodialysis.	Iron	89-93	erythropoietin	Homo sapiens	14-28
10850644-3	2000	In an initial study of food iron absorption, the effect of initiating erythropoietin therapy was determined by measuring the absorption of heme and nonheme iron before and 2 weeks after the administration of 64 U/kg body weight erythropoietin (range, 46-85 U/kg body weight) three times weekly.	Iron	28-32	erythropoietin	Homo sapiens	70-84
10850644-3	2000	In an initial study of food iron absorption, the effect of initiating erythropoietin therapy was determined by measuring the absorption of heme and nonheme iron before and 2 weeks after the administration of 64 U/kg body weight erythropoietin (range, 46-85 U/kg body weight) three times weekly.	Iron	156-160	erythropoietin	Homo sapiens	70-84
10850644-6	2000	The absorption of 50 mg of iron as ferrous sulfate increased 2.4-fold from 3.8% to 9.4% (P &lt; .05) when given without food and 4.2-fold from 1.4% to 5.9% (P &lt; .05) when given with food after erythropoietin administration.	Iron	27-31	erythropoietin	Homo sapiens	196-210
10850644-7	2000	After adjusting for changes in iron stores with serum ferritin after erythropoietin therapy, the enhanced erythropoiesis associated with erythropoietin therapy increased absorption about 2-fold, which was similar to the response observed previously in normal subjects.	Iron	31-35	erythropoietin	Homo sapiens	137-151
10850644-8	2000	In a final study we examined the absorption of therapeutic iron during the steadystate phase of erythropoietin therapy after an erythroid response to erythropoietin had occurred.	Iron	59-63	erythropoietin	Homo sapiens	96-110
10850644-9	2000	The absorption of 50 mg of iron was lower than that occurring with the initiation of erythropoietin therapy at 2.2% when given alone and 1.3% when taken with food.	Iron	27-31	erythropoietin	Homo sapiens	85-99
10811605-0	2000	The Crd1 gene encodes a putative di-iron enzyme required for photosystem I accumulation in copper deficiency and hypoxia in Chlamydomonas reinhardtii.	Iron	36-40	uncharacterized protein	Chlamydomonas reinhardtii	4-8
10820163-5	2000	The increase in FE(Pi) during PTH infusion was similar in the absence (Delta27 +/- 5%, n = 7) and presence (Delta33 +/- 6%) of methiothepin, P &gt; 0.05.	Iron	16-18	parathyroid hormone	Rattus norvegicus	30-33
10820163-7	2000	However, the increase in FE(Pi) during PTH infusion was significantly greater in the presence of methiothepin (1.3 +/- 0.9 to 20.0 +/- 4.0%, Delta18.7 +/- 3.5%) than in the vehicle-infused rats (0.5 +/- 0.2 to 8.8 +/- 1.1%, Delta8.3 +/- 1.2%; n = 8, P &lt; 0.05).	Iron	25-27	parathyroid hormone	Rattus norvegicus	39-42
10805735-0	2000	Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis.	Iron	50-54	Isa2p	Saccharomyces cerevisiae S288C	42-46
10805735-6	2000	An inspection of Isa-like proteins from bacteria to mammals revealed three invariant cysteine residues, which in the case of Isa1p and Isa2p are essential for function and may be involved in iron binding.	Iron	191-195	Isa2p	Saccharomyces cerevisiae S288C	135-140
10805735-11	2000	A model for the nonredundant roles of Isa1p and Isa2p in delivering iron to sites of the Fe-S cluster assembly is discussed.	Iron	68-72	Isa2p	Saccharomyces cerevisiae S288C	48-53
10805735-11	2000	A model for the nonredundant roles of Isa1p and Isa2p in delivering iron to sites of the Fe-S cluster assembly is discussed.	Iron	89-93	Isa2p	Saccharomyces cerevisiae S288C	48-53
10811893-13	2000	Tpk2 negatively regulates genes involved in iron uptake and positively regulates genes involved in trehalose degradation and water homeostasis.	Iron	44-48	cAMP-dependent protein kinase catalytic subunit TPK2	Saccharomyces cerevisiae S288C	0-4
10811893-14	2000	Tpk1 is required for the derepression of branched chain amino acid biosynthesis genes that seem to have a second role in the maintenance of iron levels and DNA stability within mitochondria.	Iron	140-144	cAMP-dependent protein kinase catalytic subunit TPK1	Saccharomyces cerevisiae S288C	0-4
10811893-15	2000	The fact that TPK2 mutants grow better than wild types on nonfermentable carbon sources and on media deficient in iron supports the unique role of Tpk2 in respiratory growth and carbon source use.	Iron	114-118	cAMP-dependent protein kinase catalytic subunit TPK2	Saccharomyces cerevisiae S288C	14-18
10811893-15	2000	The fact that TPK2 mutants grow better than wild types on nonfermentable carbon sources and on media deficient in iron supports the unique role of Tpk2 in respiratory growth and carbon source use.	Iron	114-118	cAMP-dependent protein kinase catalytic subunit TPK2	Saccharomyces cerevisiae S288C	147-151
10809751-9	2000	Mice with genomic deletion of heme oxygenase-1 have selective tissue iron accumulation and display augmented ATP-dependent iron transport in those tissues that accumulate iron.	Iron	69-73	heme oxygenase 1	Mus musculus	30-46
10809751-9	2000	Mice with genomic deletion of heme oxygenase-1 have selective tissue iron accumulation and display augmented ATP-dependent iron transport in those tissues that accumulate iron.	Iron	123-127	heme oxygenase 1	Mus musculus	30-46
10809751-9	2000	Mice with genomic deletion of heme oxygenase-1 have selective tissue iron accumulation and display augmented ATP-dependent iron transport in those tissues that accumulate iron.	Iron	123-127	heme oxygenase 1	Mus musculus	30-46
11073316-4	2000	Porphobilinogen deaminase (PBGD) is rate-limiting in PpIX formation whereas ferrochelatase converts PpIX into haem by chelation of ferrous iron into PpIX.	Iron	131-143	ferrochelatase	Rattus norvegicus	76-90
10844611-14	2000	We suggest that chronic up-regulation of such oxidant-inducible genes such as TGF-beta1 and MCP-1 contributes to tubulointerstitial disease, and iron-mediated oxidative stress may directly induce TGF-beta1.	Iron	145-149	transforming growth factor, beta 1	Rattus norvegicus	196-205
10828478-11	2000	Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio).	Iron	322-326	fibrinogen beta chain	Homo sapiens	49-59
10828478-12	2000	Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status.	Iron	78-82	fibrinogen beta chain	Homo sapiens	43-53
10814540-6	2000	In intestinal Caco-2 cells, DHPR mRNA levels were found to be regulated by iron.	Iron	75-79	quinoid dihydropteridine reductase	Homo sapiens	28-32
10814540-7	2000	Thus, DHPR appears to be a dual function enzyme, a NADH-dependent dihydopteridine reductase and an iron-regulated, NADH-dependent, pteridine-independent ferric reductase.	Iron	99-103	quinoid dihydropteridine reductase	Homo sapiens	6-10
10783316-11	2000	Addition of Fe or Zn to the culture medium during TRX treatment led to a complete restoration of proliferation rate and inhibition of apoptosis, demonstrating that Fe/Zn-saturated TRX was not toxic in the absence of metal depletion.	Iron	12-14	VAC14 component of PIKFYVE complex	Homo sapiens	50-53
10807584-1	2000	Heme oxygenase-1 (HO-1) is a 32-kDa microsomal enzyme that catalyzes the conversion of heme to biliverdin, releasing iron and carbon monoxide.	Iron	117-121	heme oxygenase 1	Mus musculus	0-16
10807584-1	2000	Heme oxygenase-1 (HO-1) is a 32-kDa microsomal enzyme that catalyzes the conversion of heme to biliverdin, releasing iron and carbon monoxide.	Iron	117-121	heme oxygenase 1	Mus musculus	18-22
10783316-1	2000	We investigated the effects of a new iron chelator, O-Trensox (TRX), compared with desferrioxamine (DFO), on proliferation and apoptosis in cultures of the human hepatoblastoma HepG2 and hepatocarcinoma HBG cell lines.	Iron	37-41	VAC14 component of PIKFYVE complex	Homo sapiens	63-66
10783316-11	2000	Addition of Fe or Zn to the culture medium during TRX treatment led to a complete restoration of proliferation rate and inhibition of apoptosis, demonstrating that Fe/Zn-saturated TRX was not toxic in the absence of metal depletion.	Iron	12-14	VAC14 component of PIKFYVE complex	Homo sapiens	180-183
10872741-2	2000	In this study, we investigated the roles of TfR in transferrin-bound iron (Tf-Fe) as well as transferrin-free iron (Fe II) uptake by the cells.	Iron	110-114	transferrin	Rattus norvegicus	93-104
10872741-0	2000	Transferrin-bound and transferrin free iron uptake by cultured rat astrocytes.	Iron	39-43	transferrin	Rattus norvegicus	22-33
10872741-2	2000	In this study, we investigated the roles of TfR in transferrin-bound iron (Tf-Fe) as well as transferrin-free iron (Fe II) uptake by the cells.	Iron	69-73	transferrin	Rattus norvegicus	51-62
10872741-11	2000	The results of transferrin-free iron uptake indicated that the cultured rat cortical astrocytes had the capacity to acquire Fe II.	Iron	32-36	transferrin	Rattus norvegicus	15-26
10779448-6	2000	No NTBI is found in normal sera because transferrin-bound iron is not detected in the assay.	Iron	58-62	transferrin	Homo sapiens	40-51
10872743-1	2000	Divalent metal ion transporter 1 (DMT1) is a recently identified metal-ion transporter that appears to mediate the absorption of iron in the intestine.	Iron	129-133	solute carrier family 11 member 2	Rattus norvegicus	0-32
10872750-3	2000	Iron sequestering molecules, such as ferritin, transferrin, lactotransferrin, melanotransferrin, hemosiderin and heme can serve as cytoprotectants against metal-mediated oxidant damage.	Iron	0-4	transferrin	Homo sapiens	47-58
10872750-3	2000	Iron sequestering molecules, such as ferritin, transferrin, lactotransferrin, melanotransferrin, hemosiderin and heme can serve as cytoprotectants against metal-mediated oxidant damage.	Iron	0-4	lactotransferrin	Homo sapiens	60-76
10872743-1	2000	Divalent metal ion transporter 1 (DMT1) is a recently identified metal-ion transporter that appears to mediate the absorption of iron in the intestine.	Iron	129-133	solute carrier family 11 member 2	Rattus norvegicus	34-38
10952228-0	2000	Assessment of iron status with a new fully automated assay for transferrin receptor in human serum.	Iron	14-18	transferrin	Homo sapiens	63-74
10952228-1	2000	Serum transferrin receptor is considered as a reliable marker of iron status particularly when iron deficiency is associated with chronic disorders such as inflammation, infection or malignancy.	Iron	65-69	transferrin	Homo sapiens	6-17
10952228-7	2000	In genetic hemochromatosis the concentration of soluble transferrin receptor was mostly decreased due to the regulatory effect of iron intracellular level.	Iron	130-134	transferrin	Homo sapiens	56-67
11232198-5	2000	In addition, iron has been shown to be a contributory factor in the development or progression of alcoholic liver disease, nonalcoholic liver steatohepatitis, chronic viral hepatitis, prophyria cutanea tarda, and, perhaps, in alpha 1-antitrypsin deficiency and end-stage liver disease, regardless of cause.	Iron	13-17	serpin family A member 1	Homo sapiens	226-245
10771246-6	2000	The glial transporter GLT-1 increased 5 and 15 days after iron injection on the side contralateral to the injection then returned to basal levels 30 days after the lesion.	Iron	58-62	solute carrier family 1 member 2	Rattus norvegicus	22-27
10864004-7	2000	The uptake of transferrin-bound iron (Tf-Fe2) into mucosal cells subsequently separated along the crypt-villus axis was compared to the presence of TfR, determined by immunohistochemistry using frozen and wax sections.	Iron	32-36	transferrin	Rattus norvegicus	14-25
10841644-0	2000	Insulin resistance influence iron metabolism and hepatic steatosis in type II diabetes.	Iron	29-33	insulin	Homo sapiens	0-7
10845658-0	2000	Determination of non-transferrin-bound iron in genetic hemochromatosis using a new HPLC-based method.	Iron	39-43	transferrin	Homo sapiens	21-32
10845658-1	2000	BACKGROUND/AIMS: Non-transferrin-bound iron may play a major pathogenic role in iron overload diseases due to its high hepatic uptake and potential damaging effect.	Iron	39-43	transferrin	Homo sapiens	21-32
10845658-1	2000	BACKGROUND/AIMS: Non-transferrin-bound iron may play a major pathogenic role in iron overload diseases due to its high hepatic uptake and potential damaging effect.	Iron	80-84	transferrin	Homo sapiens	21-32
10845658-2	2000	The aim of this study was to evaluate the relevance of measuring serum non-transferrin-bound iron levels in genetic hemochromatosis using a new high performance liquid chromatography-based method.	Iron	93-97	transferrin	Homo sapiens	75-86
10845658-3	2000	METHODS: This method includes a presaturation step of transferrin with cobalt(II) in order to avoid secondary deplacement of non-transferrin-bound iron toward transferrin during the assay.	Iron	147-151	transferrin	Homo sapiens	54-65
10845658-3	2000	METHODS: This method includes a presaturation step of transferrin with cobalt(II) in order to avoid secondary deplacement of non-transferrin-bound iron toward transferrin during the assay.	Iron	147-151	transferrin	Homo sapiens	129-140
10845658-3	2000	METHODS: This method includes a presaturation step of transferrin with cobalt(II) in order to avoid secondary deplacement of non-transferrin-bound iron toward transferrin during the assay.	Iron	147-151	transferrin	Homo sapiens	129-140
10845658-5	2000	RESULTS/CONCLUSIONS: The results indicate: (i) that this new method permits detection of non-transferrin-bound iron when transferrin is not fully saturated, (ii) that non-transferrin-bound iron levels persist almost until the completion of treatment, (iii) that non-transferrin-bound iron levels are well correlated with transferrin saturation for a given patient, and (iv) that despite some individual variations, a transferrin saturation value lower than 35% usually corresponds to the disappearance of non-transferrin-bound iron.	Iron	111-115	transferrin	Homo sapiens	93-104
10845658-5	2000	RESULTS/CONCLUSIONS: The results indicate: (i) that this new method permits detection of non-transferrin-bound iron when transferrin is not fully saturated, (ii) that non-transferrin-bound iron levels persist almost until the completion of treatment, (iii) that non-transferrin-bound iron levels are well correlated with transferrin saturation for a given patient, and (iv) that despite some individual variations, a transferrin saturation value lower than 35% usually corresponds to the disappearance of non-transferrin-bound iron.	Iron	111-115	transferrin	Homo sapiens	121-132
10845658-5	2000	RESULTS/CONCLUSIONS: The results indicate: (i) that this new method permits detection of non-transferrin-bound iron when transferrin is not fully saturated, (ii) that non-transferrin-bound iron levels persist almost until the completion of treatment, (iii) that non-transferrin-bound iron levels are well correlated with transferrin saturation for a given patient, and (iv) that despite some individual variations, a transferrin saturation value lower than 35% usually corresponds to the disappearance of non-transferrin-bound iron.	Iron	111-115	transferrin	Homo sapiens	121-132
10845658-5	2000	RESULTS/CONCLUSIONS: The results indicate: (i) that this new method permits detection of non-transferrin-bound iron when transferrin is not fully saturated, (ii) that non-transferrin-bound iron levels persist almost until the completion of treatment, (iii) that non-transferrin-bound iron levels are well correlated with transferrin saturation for a given patient, and (iv) that despite some individual variations, a transferrin saturation value lower than 35% usually corresponds to the disappearance of non-transferrin-bound iron.	Iron	111-115	transferrin	Homo sapiens	121-132
10845658-5	2000	RESULTS/CONCLUSIONS: The results indicate: (i) that this new method permits detection of non-transferrin-bound iron when transferrin is not fully saturated, (ii) that non-transferrin-bound iron levels persist almost until the completion of treatment, (iii) that non-transferrin-bound iron levels are well correlated with transferrin saturation for a given patient, and (iv) that despite some individual variations, a transferrin saturation value lower than 35% usually corresponds to the disappearance of non-transferrin-bound iron.	Iron	111-115	transferrin	Homo sapiens	121-132
10845658-5	2000	RESULTS/CONCLUSIONS: The results indicate: (i) that this new method permits detection of non-transferrin-bound iron when transferrin is not fully saturated, (ii) that non-transferrin-bound iron levels persist almost until the completion of treatment, (iii) that non-transferrin-bound iron levels are well correlated with transferrin saturation for a given patient, and (iv) that despite some individual variations, a transferrin saturation value lower than 35% usually corresponds to the disappearance of non-transferrin-bound iron.	Iron	111-115	transferrin	Homo sapiens	121-132
10845658-5	2000	RESULTS/CONCLUSIONS: The results indicate: (i) that this new method permits detection of non-transferrin-bound iron when transferrin is not fully saturated, (ii) that non-transferrin-bound iron levels persist almost until the completion of treatment, (iii) that non-transferrin-bound iron levels are well correlated with transferrin saturation for a given patient, and (iv) that despite some individual variations, a transferrin saturation value lower than 35% usually corresponds to the disappearance of non-transferrin-bound iron.	Iron	111-115	transferrin	Homo sapiens	121-132
10965994-0	2000	Increased levels of intracellular iron in the brains of ApoE-deficient mice with closed head injury.	Iron	34-38	apolipoprotein E	Mus musculus	56-60
10965994-2	2000	The objective of this study was to evaluate the possibility that the enhanced susceptibility of apoE-deficient mice to closed head injury is related to impairments in their antioxidative iron-chelating mechanisms.	Iron	187-191	apolipoprotein E	Mus musculus	96-100
10965994-3	2000	ApoE-deficient and control mice were subjected to closed had injury, after which the extent of brain-damage and the level of iron-containing cells were assessed.	Iron	125-129	apolipoprotein E	Mus musculus	0-4
10965994-7	2000	Numbers of iron-containing cells at Days 3 and 7 after injury were greater in the brains of control mice than in the apoE-deficient mice.	Iron	11-15	apolipoprotein E	Mus musculus	117-121
10965994-10	2000	The data suggest that the increased susceptibility of apoE-deficient mice to closed head injury may be due, at least in part, to impaired iron scavenging and sustained oxidative stress.	Iron	138-142	apolipoprotein E	Mus musculus	54-58
10770977-1	2000	Heme oxygenase-1 (HO-1) is a microsomal enzyme involved in the degradation of heme, resulting in the generation of biliverdin, iron, and carbon monoxide.	Iron	127-131	heme oxygenase 1	Mus musculus	0-16
10770977-1	2000	Heme oxygenase-1 (HO-1) is a microsomal enzyme involved in the degradation of heme, resulting in the generation of biliverdin, iron, and carbon monoxide.	Iron	127-131	heme oxygenase 1	Mus musculus	18-22
10820410-1	2000	Iron loaded transferrin (holotransferrin) was used for enrichment of fetal cells from peripheral blood of pregnant women.	Iron	0-4	transferrin	Homo sapiens	12-23
10785640-1	2000	To obtain iron from the host for growth, staphylococci have evolved sophisticated iron-scavenging systems including siderophores and a cell surface receptor for transferrin, the mammalian iron-transporting glycoprotein.	Iron	10-14	transferrin	Homo sapiens	161-172
10865496-2	2000	From a pathophysiological standpoint, the C282Y mutation impairs HFE protein expression at the surface of the membrane and disturbs the cellular entry of iron (carried by circulating transferrin) into the cryptic duodenal cell.	Iron	154-158	transferrin	Homo sapiens	183-194
10785640-1	2000	To obtain iron from the host for growth, staphylococci have evolved sophisticated iron-scavenging systems including siderophores and a cell surface receptor for transferrin, the mammalian iron-transporting glycoprotein.	Iron	82-86	transferrin	Homo sapiens	161-172
10772915-0	2000	Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of iron-mediated oxidation of proline and arginine side-chain residues of low-density lipoprotein apolipoprotein B-100.	Iron	69-73	apolipoprotein B	Homo sapiens	164-184
10818501-0	2000	The effect of iron and aluminum on transferrin and other serum proteins as revealed by isoelectric focusing gel electrophoresis.	Iron	14-18	transferrin	Homo sapiens	35-46
10771090-6	2000	In the transfectants, HFE protein decreased the rate of transferrin receptor-dependent iron ((59)Fe) uptake by the cells, but did not change the rate of iron release, indicating that HFE protein decreased the rate of iron influx.	Iron	87-91	transferrin	Homo sapiens	56-67
10771090-6	2000	In the transfectants, HFE protein decreased the rate of transferrin receptor-dependent iron ((59)Fe) uptake by the cells, but did not change the rate of iron release, indicating that HFE protein decreased the rate of iron influx.	Iron	97-99	transferrin	Homo sapiens	56-67
10771090-11	2000	Our results strongly suggest an additional role of HFE on transferrin receptor recycling in addition to the decrease of receptor affinity, resulting in the reduced cellular iron.	Iron	173-177	transferrin	Homo sapiens	58-69
10744769-7	2000	Deletion of ARN3 did not prevent yeast from using ferrioxamine B as an iron source; however, deletion of ARN3 and FET3, a component of the high affinity ferrous iron transport system, did prevent uptake of ferrioxamine-bound iron and growth on ferrioxamine as an iron source.	Iron	161-165	siderophore transporter	Saccharomyces cerevisiae S288C	105-109
10744769-7	2000	Deletion of ARN3 did not prevent yeast from using ferrioxamine B as an iron source; however, deletion of ARN3 and FET3, a component of the high affinity ferrous iron transport system, did prevent uptake of ferrioxamine-bound iron and growth on ferrioxamine as an iron source.	Iron	161-165	siderophore transporter	Saccharomyces cerevisiae S288C	105-109
10744769-7	2000	Deletion of ARN3 did not prevent yeast from using ferrioxamine B as an iron source; however, deletion of ARN3 and FET3, a component of the high affinity ferrous iron transport system, did prevent uptake of ferrioxamine-bound iron and growth on ferrioxamine as an iron source.	Iron	161-165	siderophore transporter	Saccharomyces cerevisiae S288C	105-109
10818508-3	2000	Transferrin is the carrier protein for iron in the blood, while ApoE is involved with the transport and redistribution of lipids.	Iron	39-43	transferrin	Homo sapiens	0-11
10772426-12	2000	However, postnatal age at therapy initiation, postconceptional age at therapy discontinuation, mean epoetin alfa dosage, and iron dosage correlate with specific outcomes of epoetin alfa therapy in premature infants.	Iron	125-129	erythropoietin	Homo sapiens	173-180
10809415-4	2000	PATIENTS AND METHODS: We hypothesized that intradialytic oral iron therapy can overcome compliance problems and support effective maintenance erythropoiesis, which will keep Hct in the range of 33% to 36% and EPO requirements up to 50 units/week/kg.	Iron	62-66	erythropoietin	Homo sapiens	209-212
10810182-5	2000	The iron transport protein transferrin in iron-saturated and iron-depleted forms can also inhibit Ca-CM-independent PDE activity by two-fold.	Iron	4-8	serotransferrin	Bos taurus	27-38
10810182-5	2000	The iron transport protein transferrin in iron-saturated and iron-depleted forms can also inhibit Ca-CM-independent PDE activity by two-fold.	Iron	42-46	serotransferrin	Bos taurus	27-38
10759472-6	2000	RESULTS: The in vitro transferrin iron load was complete and stable.	Iron	34-38	transferrin	Homo sapiens	22-33
10809415-5	2000	In a prospective observational study, SC EPO-treated hospital-based HD patients without conditions known to cause EPO resistance, were managed on intradialytic oral administration of iron and vitamin C.	Iron	183-187	erythropoietin	Homo sapiens	41-44
10809415-14	2000	CONCLUSION: In conclusion, intradialytic oral iron therapy can support effective maintenance erythropoiesis in 50% of patients without known causes for EPO resistance.	Iron	46-50	erythropoietin	Homo sapiens	152-155
10735848-14	2000	The first operon, orf1-tolQRA, is iron regulated throughout growth, but iron-regulated expression of tolB and oprL fusions occurs only in late log phase.	Iron	34-38	hypothetical protein	Escherichia coli	18-22
10741855-6	2000	Mobilization of iron was also indicated by 49% increase in plasma iron and a 77% increase in plasma transferrin saturation.	Iron	16-20	transferrin	Rattus norvegicus	100-111
10765081-8	2000	CONCLUSION: Immunohistochemical staining for cytokeratin 7 may be useful for the differential diagnosis of renal oncocytomas and chromophobe renal cell carcinomas when Hale"s colloidal iron staining is uncertain.	Iron	185-189	keratin 7	Homo sapiens	45-58
10735848-14	2000	The first operon, orf1-tolQRA, is iron regulated throughout growth, but iron-regulated expression of tolB and oprL fusions occurs only in late log phase.	Iron	72-76	hypothetical protein	Escherichia coli	18-22
10830884-3	2000	In normal human plasma almost all iron loading of transferrin is 20-30% maximum.	Iron	34-38	transferrin	Homo sapiens	50-61
10991672-8	2000	Both radical scavengers and iron chelators prevent lipopolysaccharide (LPS) and iron-induced activation of NF kappa-beta.	Iron	28-32	nuclear factor kappa B subunit 1	Homo sapiens	107-120
10737607-0	2000	Sodium nitroprusside prevents chemical hypoxia-induced cell death through iron ions stimulating the activity of the Na+-Ca2+ exchanger in C6 glioma cells.	Iron	74-78	solute carrier family 8 member A1	Homo sapiens	116-134
10737607-8	2000	Collectively, these findings suggest that the protective effect of SNP on C6 glioma cells exposed to chemical hypoxia is due to the activation of the Na+-Ca2+ exchanger operating as a Na+ efflux-Ca2+ influx pathway induced by iron present in the SNP molecule.	Iron	226-230	solute carrier family 8 member A1	Homo sapiens	150-168
10991672-8	2000	Both radical scavengers and iron chelators prevent lipopolysaccharide (LPS) and iron-induced activation of NF kappa-beta.	Iron	80-84	nuclear factor kappa B subunit 1	Homo sapiens	107-120
11961585-1	2000	The changes in transferrin(Tf)-bound and non-Tf-bound iron uptake were observed in bone marrow cells from rats with exercise-induced low iron status.	Iron	137-141	transferrin	Rattus norvegicus	15-26
10827345-14	2000	The iron accumulation in spleen and bone marrow may be related to reduced iron transport due to inhibition of transferrin synthesis rather than inhibition of transferrin sialylation.	Iron	4-8	transferrin	Rattus norvegicus	110-121
10827345-14	2000	The iron accumulation in spleen and bone marrow may be related to reduced iron transport due to inhibition of transferrin synthesis rather than inhibition of transferrin sialylation.	Iron	74-78	transferrin	Rattus norvegicus	110-121
11111550-0	2000	Iron overload in the erythropoietin era.	Iron	0-4	erythropoietin	Homo sapiens	21-35
11111550-1	2000	Increasing use of maintenance parenteral iron in the erythropoietin (EPO) era has been accompanied by growing concern about iron overload.	Iron	41-45	erythropoietin	Homo sapiens	53-67
11111550-1	2000	Increasing use of maintenance parenteral iron in the erythropoietin (EPO) era has been accompanied by growing concern about iron overload.	Iron	41-45	erythropoietin	Homo sapiens	69-72
11111550-1	2000	Increasing use of maintenance parenteral iron in the erythropoietin (EPO) era has been accompanied by growing concern about iron overload.	Iron	124-128	erythropoietin	Homo sapiens	69-72
11111550-3	2000	The condition is less common in all dialysis patients today than it was in the pre-EPO era, since fewer patients are being transfused and EPO therapy shifts iron into erythroid cells.	Iron	157-161	erythropoietin	Homo sapiens	138-141
11111550-6	2000	Clinically significant iron overload, which rarely occurs if ESRD patients are properly managed, can be treated in most EPO-treated renal failure patients by simply withholding parenteral iron therapy.	Iron	23-27	erythropoietin	Homo sapiens	120-123
11111550-6	2000	Clinically significant iron overload, which rarely occurs if ESRD patients are properly managed, can be treated in most EPO-treated renal failure patients by simply withholding parenteral iron therapy.	Iron	188-192	erythropoietin	Homo sapiens	120-123
10981814-0	2000	Molecular modeling of human serum transferrin for rationalizing the changes in its physicochemical properties induced by iron binding.	Iron	121-125	transferrin	Homo sapiens	34-45
10981814-2	2000	In order to rationalize the physicochemical properties of human serum-transferrin (STf) and the STf-receptor (TfR) recognition process, we have tried to predict the 3D structures of apo- and iron-loaded STf using a homology modeling technique to study the changes in the structural characteristics that take place upon the uptake of iron by STf in solution.	Iron	191-195	transferrin	Homo sapiens	70-81
10763998-6	2000	METHODS: Transferrin is a ubiquitous monomeric glycoprotein consisting of 679 amino acids, two iron-binding sites, and two N-linked complex glycan chains.	Iron	95-99	transferrin	Homo sapiens	9-20
10763998-16	2000	RESULTS: This microelectrophoretic technique, using only 0.3 microL of iron-loaded sample, was able to consistently detect less than 250 pg of transferrin in solution and separate the different sialylation variants based on their isoelectric points.	Iron	71-75	transferrin	Homo sapiens	143-154
10763998-22	2000	CONCLUSIONS: Microelectrophoretic assay of iron-loaded transferrin can detect as little as 250 pg of protein and can identify microheterogeneity in serum, CSF, and perilymph.	Iron	43-47	transferrin	Homo sapiens	55-66
10699376-9	2000	Increased iron saturation of transferrin eliminates its ability to bind reactive forms of iron and to act as an antioxidant.	Iron	10-14	transferrin	Homo sapiens	29-40
10699376-9	2000	Increased iron saturation of transferrin eliminates its ability to bind reactive forms of iron and to act as an antioxidant.	Iron	90-94	transferrin	Homo sapiens	29-40
10699376-10	2000	When transferrin is fully saturated with iron, reactive forms of iron are present in the plasma which can stimulate iron-driven oxidative reactions.	Iron	41-45	transferrin	Homo sapiens	5-16
10699376-10	2000	When transferrin is fully saturated with iron, reactive forms of iron are present in the plasma which can stimulate iron-driven oxidative reactions.	Iron	65-69	transferrin	Homo sapiens	5-16
10699376-10	2000	When transferrin is fully saturated with iron, reactive forms of iron are present in the plasma which can stimulate iron-driven oxidative reactions.	Iron	65-69	transferrin	Homo sapiens	5-16
10713272-2	2000	Iron-treated cells showed a 50% decrease in apolipoprotein B100 (Apo B100) and a 2- and 3-fold increase in semaphorin cd100 and aldose reductase mRNA, respectively, with parallel variations in Apo B100 and aldose reductase proteins.	Iron	0-4	apolipoprotein B	Homo sapiens	44-63
10713272-2	2000	Iron-treated cells showed a 50% decrease in apolipoprotein B100 (Apo B100) and a 2- and 3-fold increase in semaphorin cd100 and aldose reductase mRNA, respectively, with parallel variations in Apo B100 and aldose reductase proteins.	Iron	0-4	apolipoprotein B	Homo sapiens	65-73
10713272-2	2000	Iron-treated cells showed a 50% decrease in apolipoprotein B100 (Apo B100) and a 2- and 3-fold increase in semaphorin cd100 and aldose reductase mRNA, respectively, with parallel variations in Apo B100 and aldose reductase proteins.	Iron	0-4	aldo-keto reductase family 1 member B	Homo sapiens	128-144
10713272-2	2000	Iron-treated cells showed a 50% decrease in apolipoprotein B100 (Apo B100) and a 2- and 3-fold increase in semaphorin cd100 and aldose reductase mRNA, respectively, with parallel variations in Apo B100 and aldose reductase proteins.	Iron	0-4	apolipoprotein B	Homo sapiens	193-201
10713272-2	2000	Iron-treated cells showed a 50% decrease in apolipoprotein B100 (Apo B100) and a 2- and 3-fold increase in semaphorin cd100 and aldose reductase mRNA, respectively, with parallel variations in Apo B100 and aldose reductase proteins.	Iron	0-4	aldo-keto reductase family 1 member B	Homo sapiens	206-222
10673305-3	2000	Unsaturated iron binding capacity is a surrogate marker of transferrin saturation and its measurement can be automated.	Iron	12-16	transferrin	Homo sapiens	59-70
10725111-7	2000	The removal of the glass-phase iron greatly reduced the amount of iron that could be mobilized by citrate and prevented the particles from inducing interleukin-8 in cultured human lung epithelial (A549) cells.	Iron	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
10725111-7	2000	The removal of the glass-phase iron greatly reduced the amount of iron that could be mobilized by citrate and prevented the particles from inducing interleukin-8 in cultured human lung epithelial (A549) cells.	Iron	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
17024033-9	2000	Nramp2, also called DMT1 (divalent metal ion transporter), seems to be a major regulator of transferrin-independent, nonheme iron uptake.	Iron	125-129	transferrin	Homo sapiens	92-103
10754275-0	2000	Modifications in heme iron of free and vesicle bound cytochrome c by tert-butyl hydroperoxide: a magnetic circular dichroism and electron paramagnetic resonance investigation.	Iron	22-26	cytochrome c, somatic	Homo sapiens	53-65
10692416-0	2000	Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2.	Iron	65-69	interferon gamma	Mus musculus	11-27
10692002-0	2000	Non-transferrin-bound iron is present in serum of hereditary haemochromatosis heterozygotes.	Iron	22-26	transferrin	Homo sapiens	4-15
10692002-4	2000	In iron overload conditions, non-transferrin-bound iron (NTBI) is found in serum, which can catalyze lipid peroxidation.	Iron	3-7	transferrin	Homo sapiens	33-44
10692002-4	2000	In iron overload conditions, non-transferrin-bound iron (NTBI) is found in serum, which can catalyze lipid peroxidation.	Iron	51-55	transferrin	Homo sapiens	33-44
10754275-2	2000	Direct low-temperature (11 degrees K) EPR analysis of the cytochrome c heme iron on exposure to tert-BuOOH shows a gradual (180 s) conversion of the low-spin form to a high-spin Fe(III) species of rhombic symmetry (g = 4.3), with disappearance of a prior peroxyl radical signal (g(o) = 2.014).	Iron	76-80	cytochrome c, somatic	Homo sapiens	58-70
10754275-7	2000	The EPR results show that the primary initial change on exposure of cytochrome c to tert-BuOOH is a change to a high-spin Fe(III) species, and together with MCD measurements show that unsaturated cardiolipin-containing lipid membranes influence the interaction of tert-BuOOH with cytochrome c heme iron, to alter radical production and decrease damage to the cytochrome.	Iron	298-302	cytochrome c, somatic	Homo sapiens	68-80
10815346-6	2000	Besides conventional methods, the concentration of soluble transferrin receptor was used as leading indicator of iron status.	Iron	113-117	transferrin	Homo sapiens	59-70
10703677-0	2000	Optimization of epoetin therapy with intravenous iron therapy in hemodialysis patients.	Iron	49-53	erythropoietin	Homo sapiens	16-23
10706565-1	2000	Patients with chronic hepatitis C and low serum and hepatic iron stores may have an improved response to interferon (IFN).	Iron	60-64	interferon alpha 1	Homo sapiens	117-120
10706565-10	2000	We conclude that iron reduction via therapeutic phlebotomy improves the end-of-treatment virological and histological response to short-term IFN therapy.	Iron	17-21	interferon alpha 1	Homo sapiens	141-144
10703678-1	2000	Intravenous iron application to anemic patients on hemodialysis leads to an "oversaturation" of transferrin.	Iron	12-16	transferrin	Homo sapiens	96-107
10703678-2	2000	As a result, non-transferrin-bound, redox-active iron might induce lipid peroxidation.	Iron	49-53	transferrin	Homo sapiens	17-28
10681454-4	2000	Recently a human cDNA highly homologous to TfR was identified and reported to encode a protein (TfR2) that binds holotransferrin and mediates uptake of transferrin-bound iron.	Iron	170-174	transferrin	Homo sapiens	117-128
10710409-5	2000	Iron supplementation increased serum ferritin and decreased transferrin receptors in the S compared with the P group.	Iron	0-4	transferrin	Homo sapiens	60-71
10692595-5	2000	A cytochrome P-450 mediated iron dependent epoxidation type mechanism is suggested for ESP.	Iron	28-32	epithiospecifier protein-like	Brassica napus	87-90
10681518-3	2000	Myeloperoxidase and inducible nitric-oxide synthase are both stored in and secreted from the primary granules of activated leukocytes, and nitric oxide (nitrogen monoxide; NO) reacts with the iron center of hemeproteins at near diffusion-controlled rates.	Iron	192-196	myeloperoxidase	Homo sapiens	0-15
10684597-0	2000	Mutations at the histidine 249 ligand profoundly alter the spectral and iron-binding properties of human serum transferrin N-lobe.	Iron	72-76	transferrin	Homo sapiens	111-122
10721144-3	2000	Iron and manganese in the samples were also oxidized and, by sequestering the resultant As(V), played a significant role in the rate of reaction.	Iron	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	88-93
10693807-0	2000	Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.	Iron	79-83	solute carrier family 40 member 1	Danio rerio	32-44
10693807-6	2000	The gene, ferroportin1, encodes a multiple-transmembrane domain protein, expressed in the yolk sac, that is a candidate for the elusive iron exporter.	Iron	136-140	solute carrier family 40 member 1	Danio rerio	10-22
10693807-7	2000	Zebrafish ferroportin1 is required for the transport of iron from maternally derived yolk stores to the circulation and functions as an iron exporter when expressed in Xenopus oocytes.	Iron	56-60	solute carrier family 40 member 1	Danio rerio	10-22
10693807-7	2000	Zebrafish ferroportin1 is required for the transport of iron from maternally derived yolk stores to the circulation and functions as an iron exporter when expressed in Xenopus oocytes.	Iron	136-140	solute carrier family 40 member 1	Danio rerio	10-22
10744316-2	2000	It indicates a group of isoforms of human transferrin (Tf), the main iron transport serum protein, deficient in sialic acid residues (asialo-, monosialo- and disialo-Tf) in comparison to the main isotransferrin which contains four sialic acid groups (tetrasialo-Tf).	Iron	69-73	transferrin	Homo sapiens	42-53
10744316-2	2000	It indicates a group of isoforms of human transferrin (Tf), the main iron transport serum protein, deficient in sialic acid residues (asialo-, monosialo- and disialo-Tf) in comparison to the main isotransferrin which contains four sialic acid groups (tetrasialo-Tf).	Iron	69-73	transferrin	Homo sapiens	55-57
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Iron	24-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-153
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Iron	24-28	erythropoietin	Homo sapiens	169-183
10679259-1	2000	The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction.	Iron	24-28	erythropoietin	Homo sapiens	185-188
10684597-1	2000	Human serum transferrin is an iron-binding and -transport protein which carries iron from the blood stream into various cells.	Iron	30-34	transferrin	Homo sapiens	12-23
10684597-1	2000	Human serum transferrin is an iron-binding and -transport protein which carries iron from the blood stream into various cells.	Iron	80-84	transferrin	Homo sapiens	12-23
10684598-0	2000	Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.	Iron	16-20	transferrin	Homo sapiens	66-77
10684598-1	2000	Serum transferrin is the major iron transport protein in humans.	Iron	31-35	transferrin	Homo sapiens	6-17
10684598-3	2000	Possible explanations for the release of iron from transferrin at low pH include protonation of a histidine ligand and the existence of a pH-sensitive "trigger" involving a hydrogen-bonded pair of lysines in the N-lobe of transferrin.	Iron	41-45	transferrin	Homo sapiens	51-62
10684598-3	2000	Possible explanations for the release of iron from transferrin at low pH include protonation of a histidine ligand and the existence of a pH-sensitive "trigger" involving a hydrogen-bonded pair of lysines in the N-lobe of transferrin.	Iron	41-45	transferrin	Homo sapiens	222-233
10684598-4	2000	We have determined the crystal structure of the His249Glu mutant of the N-lobe half-molecule of human transferrin and compared its iron-binding properties with those of the wild-type protein and other mutants.	Iron	131-135	transferrin	Homo sapiens	102-113
10691878-2	2000	Progressive iron depletion and deficiency - most apparent from serum concentrations of soluble transferrin receptor divided by the logarithm of ferritin concentrations (the TfR-F index) - developed in men donating up to six times in 2 years, although the serum ferritin alone was also informative; however, no prediction could be made for those iron-depleted individuals who will develop iron deficiency after donation.	Iron	12-16	transferrin	Homo sapiens	95-106
10685854-12	2000	Transferrin evaluation in MS may also be of significant theoretical interest, since transferrin is known to be involved in the regulation of iron metabolism and it may have a protective role against the oxidative stress.	Iron	141-145	transferrin	Homo sapiens	0-11
10685854-12	2000	Transferrin evaluation in MS may also be of significant theoretical interest, since transferrin is known to be involved in the regulation of iron metabolism and it may have a protective role against the oxidative stress.	Iron	141-145	transferrin	Homo sapiens	84-95
11049207-1	2000	We examined the efficacy of interferon (IFN) therapy for chronic hepatitis C (CHC) in view of the change of liver histology and iron staining before and after IFN therapy.	Iron	128-132	interferon alpha 1	Homo sapiens	40-43
10666115-1	2000	Heme oxygenase (HO)-1 catalyzes the oxidative cleavage of heme to yield equimolar amounts of biliverdin, iron, and carbon monoxide.	Iron	105-109	heme oxygenase 1	Mus musculus	0-21
10691878-2	2000	Progressive iron depletion and deficiency - most apparent from serum concentrations of soluble transferrin receptor divided by the logarithm of ferritin concentrations (the TfR-F index) - developed in men donating up to six times in 2 years, although the serum ferritin alone was also informative; however, no prediction could be made for those iron-depleted individuals who will develop iron deficiency after donation.	Iron	345-349	transferrin	Homo sapiens	95-106
11049207-10	2000	The positive rate for iron staining tended to decrease after IFN therapy, not correlating to the response to IFN, but the change was not statistically significant.	Iron	22-26	interferon alpha 1	Homo sapiens	61-64
10688536-0	2000	Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal.	Iron	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10690503-3	2000	In plasma and interstitial fluids, Fe is carried by transferrin.	Iron	35-37	transferrin	Rattus norvegicus	52-63
10690503-4	2000	Iron-containing transferrin has a high affinity for the transferrin receptor, which is present on all cells with a requirement for Fe.	Iron	0-4	transferrin	Rattus norvegicus	16-27
10690503-4	2000	Iron-containing transferrin has a high affinity for the transferrin receptor, which is present on all cells with a requirement for Fe.	Iron	131-133	transferrin	Rattus norvegicus	16-27
10690503-5	2000	The degree of expression of transferrin receptors on most types of cells is determined by the level of Fe supply and their rate of proliferation.	Iron	103-105	transferrin	Rattus norvegicus	28-39
10690503-15	2000	In the second, Fe transport is the result of receptor-mediated endocytosis of Fe-transferrin by capillary endothelial cells, followed by release of Fe from transferrin within the cell, recycling of transferrin to the blood, and transport of Fe into the brain.	Iron	15-17	transferrin	Rattus norvegicus	81-92
10690503-15	2000	In the second, Fe transport is the result of receptor-mediated endocytosis of Fe-transferrin by capillary endothelial cells, followed by release of Fe from transferrin within the cell, recycling of transferrin to the blood, and transport of Fe into the brain.	Iron	15-17	transferrin	Rattus norvegicus	156-167
10690503-15	2000	In the second, Fe transport is the result of receptor-mediated endocytosis of Fe-transferrin by capillary endothelial cells, followed by release of Fe from transferrin within the cell, recycling of transferrin to the blood, and transport of Fe into the brain.	Iron	15-17	transferrin	Rattus norvegicus	156-167
10690503-15	2000	In the second, Fe transport is the result of receptor-mediated endocytosis of Fe-transferrin by capillary endothelial cells, followed by release of Fe from transferrin within the cell, recycling of transferrin to the blood, and transport of Fe into the brain.	Iron	78-80	transferrin	Rattus norvegicus	81-92
10690503-15	2000	In the second, Fe transport is the result of receptor-mediated endocytosis of Fe-transferrin by capillary endothelial cells, followed by release of Fe from transferrin within the cell, recycling of transferrin to the blood, and transport of Fe into the brain.	Iron	78-80	transferrin	Rattus norvegicus	81-92
10690503-19	2000	Iron-containing transferrin is transported through the blood-CSF barrier by a mechanism that appears to be regulated by developmental stage and iron status.	Iron	0-4	transferrin	Rattus norvegicus	16-27
10690503-19	2000	Iron-containing transferrin is transported through the blood-CSF barrier by a mechanism that appears to be regulated by developmental stage and iron status.	Iron	144-148	transferrin	Rattus norvegicus	16-27
10690503-24	2000	The uptake of transferrin-bound Fe by neurons and glial cells is probably regulated by the number of transferrin receptors present on cells, which changes during development and in conditions with an altered iron status.	Iron	32-34	transferrin	Rattus norvegicus	14-25
10690503-24	2000	The uptake of transferrin-bound Fe by neurons and glial cells is probably regulated by the number of transferrin receptors present on cells, which changes during development and in conditions with an altered iron status.	Iron	32-34	transferrin	Rattus norvegicus	101-112
10690503-24	2000	The uptake of transferrin-bound Fe by neurons and glial cells is probably regulated by the number of transferrin receptors present on cells, which changes during development and in conditions with an altered iron status.	Iron	208-212	transferrin	Rattus norvegicus	14-25
10690503-24	2000	The uptake of transferrin-bound Fe by neurons and glial cells is probably regulated by the number of transferrin receptors present on cells, which changes during development and in conditions with an altered iron status.	Iron	208-212	transferrin	Rattus norvegicus	101-112
10688536-2	2000	We tested the hypothesis that iron present in coal fly ash (CFA) could induce the expression and synthesis of the inflammatory cytokine interleukin-8 (IL-8).	Iron	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	136-149
10688536-2	2000	We tested the hypothesis that iron present in coal fly ash (CFA) could induce the expression and synthesis of the inflammatory cytokine interleukin-8 (IL-8).	Iron	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Iron	344-348	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Iron	344-348	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10688536-7	2000	Treatment with a soluble form of iron, ferric ammonium citrate (FAC), mimicked the IL-8 level increase observed with CFA.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10688536-8	2000	There was a direct relationship, above a threshold level of bioavailable iron, between the levels of IL-8 and bioavailable iron in A549 cells treated with CFA or FAC.	Iron	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
10657727-0	2000	Improved response to erythropoietin therapy with long-term continuous iron supplementation.	Iron	70-74	erythropoietin	Homo sapiens	21-35
10688536-8	2000	There was a direct relationship, above a threshold level of bioavailable iron, between the levels of IL-8 and bioavailable iron in A549 cells treated with CFA or FAC.	Iron	123-127	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
10688536-9	2000	Further, the relationship between IL-8 and bioavailable iron for CFA was indistinguishable from that for FAC.	Iron	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10688536-10	2000	These results strongly suggest that iron can induce IL-8 in A549 cells and that iron was the likely component of CFA that induced IL-8.	Iron	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
10688536-10	2000	These results strongly suggest that iron can induce IL-8 in A549 cells and that iron was the likely component of CFA that induced IL-8.	Iron	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
10722800-5	2000	Total TGF- beta bioactivity was also decreased by iron loading.	Iron	50-54	transforming growth factor, beta 1	Rattus norvegicus	6-15
10746799-7	2000	However, reduced iron availability, inadequate dialysis, infection and hyperparathyroidism can all impair the efficacy of EPO.	Iron	17-21	erythropoietin	Homo sapiens	122-125
10705106-2	2000	Heterozygosity for GH is associated with a mild increase in iron metabolism parameters, and increased iron stores are associated with abnormal glucose tolerance and decreased insulin sensitivity in the general population.	Iron	102-106	insulin	Homo sapiens	175-182
10705106-9	2000	This finding suggests that, in the absence of obesity, HFE mutations, through the insulin resistance associated with the increase in iron stores, may contribute to the onset of type 2 diabetes.	Iron	133-137	insulin	Homo sapiens	82-89
10644324-10	2000	CONCLUSIONS: Results are consistent with a role for DMT1 in the transmembrane transport of non-transferrin bound iron from the intestinal lumen and from the portal blood.	Iron	113-117	transferrin	Rattus norvegicus	95-106
10669330-4	2000	Expression of p24 antigen in human monocyte-derived macrophages and peripheral blood lymphocytes (PBL) was reduced by all 3 iron chelators.	Iron	124-128	transmembrane p24 trafficking protein 2	Homo sapiens	14-17
10722800-4	2000	In myocytes iron caused a dose-dependent decline in mRNAs coding for transforming growth factor- beta(1)(TGF- beta(1)), biglycan, and collagen type I while plasminogen activator inhibitor-1 mRNA was unaffected by iron loading and decorin mRNA doubled.	Iron	12-16	transforming growth factor, beta 1	Rattus norvegicus	69-117
10852693-4	2000	iron to optimize their response to erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	35-49
10648854-7	2000	The determination of transferrin in BAS of preterm infants is helpful in determining oxidative damage, e.g. the availability of free iron, in the neonatal lung.	Iron	133-137	transferrin	Homo sapiens	21-32
10852693-6	2000	iron reduces erythropoietin dose requirements, resulting in cost savings.	Iron	0-4	erythropoietin	Homo sapiens	13-27
10733616-7	2000	Thus early-onset RLS appears to occur commonly in families, slowly progress with age and have a limited relation to serum iron status.	Iron	122-126	RLS1	Homo sapiens	17-20
10733616-8	2000	In contrast, late-onset RLS appears to occur less commonly in families, rapidly progress with age and have a strong relation to serum iron status.	Iron	134-138	RLS1	Homo sapiens	24-27
10648828-5	2000	This demonstrates that, after its release from transferrin, iron is transported to the cytoplasm directly from the early endosome without the need for fusion of the iron-containing vesicle with a lysosome.	Iron	60-64	transferrin	Rattus norvegicus	47-58
10627487-2	2000	The transport of Fe is stimulated by the presence of either apo-transferrin (apo-Tf) or ferri-transferrin (Fe-Tf) in the basal chamber with the stimulation occurring at much lower concentrations of apo-Tf than Fe-Tf.	Iron	17-19	transferrin	Homo sapiens	64-75
10627487-2	2000	The transport of Fe is stimulated by the presence of either apo-transferrin (apo-Tf) or ferri-transferrin (Fe-Tf) in the basal chamber with the stimulation occurring at much lower concentrations of apo-Tf than Fe-Tf.	Iron	17-19	transferrin	Homo sapiens	94-105
10625675-8	2000	Based on the crystal structure of the reticulocyte 15-LOX, these two amino acids lie opposite the open coordination position of the catalytic iron in a likely site for substrate binding.	Iron	142-146	arachidonate 15-lipoxygenase	Homo sapiens	51-57
10677450-5	2000	The cytosolic aconitase in animals, in addition to being a key redox and NO sensor, is converted by NO into an mRNA binding protein (IRP, or iron-regulatory protein) that regulates iron homeostasis.	Iron	141-145	aconitate hydratase, cytoplasmic-like	Nicotiana tabacum	4-23
10636858-2	2000	When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the transferrin receptor, resulting in diminished translation of the ferritin mRNA and increased translation of the transferrin receptor mRNA.	Iron	18-22	transferrin	Homo sapiens	92-103
10636858-2	2000	When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the transferrin receptor, resulting in diminished translation of the ferritin mRNA and increased translation of the transferrin receptor mRNA.	Iron	18-22	transferrin	Homo sapiens	204-215
10623624-1	2000	A novel molecular modeling study, involving inhibitors bound to the iron of cytochrome P450 heme, is described for nonsteroidal inhibitors of aromatase (AR).	Iron	68-72	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	142-151
10638746-2	2000	HFE binds to the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded transferrin.	Iron	79-83	transferrin	Homo sapiens	17-28
10623624-1	2000	A novel molecular modeling study, involving inhibitors bound to the iron of cytochrome P450 heme, is described for nonsteroidal inhibitors of aromatase (AR).	Iron	68-72	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	153-155
10638746-6	2000	The HFE-TfR complex suggests a binding site for transferrin on TfR and sheds light upon the function of HFE in regulating iron homeostasis.	Iron	122-126	transferrin	Homo sapiens	48-59
10863545-8	2000	Both radical scavengers and iron chelators prevent LPS (lipopolysaccharide) and iron induced activation of NF kappa-B.	Iron	28-32	nuclear factor kappa B subunit 1	Homo sapiens	107-117
10607912-1	2000	Heme oxygenase (HO)-2, the constitutive cognate of oxidative stress inducible HO-1 (HSP32), degrades heme to biliverdin, carbon monoxide, and iron.	Iron	142-146	heme oxygenase 2	Rattus norvegicus	0-21
11045265-5	2000	Significant differences in iron parameters were seen between periods I and III, or I and IV for transferrin (212 +/- 41 mg/dL vs 253 +/- 36 mg/dL), TIBC (304 +/- 40 micrograms/dL vs 338 +/- 31 micrograms/dL) and TSAT (34% +/- 15% vs 24% +/- 4%).	Iron	27-31	transferrin	Homo sapiens	96-107
10863545-8	2000	Both radical scavengers and iron chelators prevent LPS (lipopolysaccharide) and iron induced activation of NF kappa-B.	Iron	80-84	nuclear factor kappa B subunit 1	Homo sapiens	107-117
15693280-2	2000	When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the transferrin receptor, resulting in diminished translation of the ferritin mRNA and increased translation of the transferrin receptor mRNA.	Iron	18-22	transferrin	Homo sapiens	92-103
11201204-6	2000	Thus, such fine perineuronal sulfated proteoglycans as those in the CA3 field of the hippocampus, which are weakly stained with cationic iron colloid and usually overlooked by a demonstration with only a Prussian blue reaction, could be clearly visualized with striking contrast by the sensitized development with Bodian"s protein silver after the Prussian blue reaction.	Iron	137-141	carbonic anhydrase 3	Mus musculus	68-71
10605937-1	2000	A family of non-coding sequences in the mRNA (iso-IREs [iron-responsive elements]) regulate synthesis of key proteins in animal iron and oxidative metabolism such as ferritin and mitochondrial aconitase.	Iron	56-60	aconitase 2	Homo sapiens	179-202
10605937-1	2000	A family of non-coding sequences in the mRNA (iso-IREs [iron-responsive elements]) regulate synthesis of key proteins in animal iron and oxidative metabolism such as ferritin and mitochondrial aconitase.	Iron	128-132	aconitase 2	Homo sapiens	179-202
15693280-2	2000	When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the transferrin receptor, resulting in diminished translation of the ferritin mRNA and increased translation of the transferrin receptor mRNA.	Iron	18-22	transferrin	Homo sapiens	204-215
15693280-4	2000	Intestinal epithelia cells sense body iron through the basolateral endocytosis of plasma transferrin.	Iron	38-42	transferrin	Homo sapiens	89-100
15693280-5	2000	Transferrin endocytosis results in enterocytes whose iron content will depend on the iron saturation of plasma transferrin.	Iron	53-57	transferrin	Homo sapiens	0-11
15693280-5	2000	Transferrin endocytosis results in enterocytes whose iron content will depend on the iron saturation of plasma transferrin.	Iron	53-57	transferrin	Homo sapiens	111-122
15693280-5	2000	Transferrin endocytosis results in enterocytes whose iron content will depend on the iron saturation of plasma transferrin.	Iron	85-89	transferrin	Homo sapiens	0-11
15693280-5	2000	Transferrin endocytosis results in enterocytes whose iron content will depend on the iron saturation of plasma transferrin.	Iron	85-89	transferrin	Homo sapiens	111-122
11381190-9	2000	Blood total iron was significantly reduced in GrII(a,b) (15.6 and 12%) (8.8%) bilirubin, GGT and AST in this order are good discriminators between the different subgroups in GrII.	Iron	12-16	solute carrier family 17 member 5	Homo sapiens	97-100
10824411-12	2000	In probands on alternative nutrition with iron deficit was significantly lower activity of delta 6 desaturase determined.	Iron	42-46	fatty acid desaturase 2	Homo sapiens	91-109
10989545-5	2000	Otherwise, the recently described insulin resistance-associated liver iron overload syndrome might account for epidemiological associations that have been reported between increased body iron stores and cancerous, cardio-vascular and hepatic disorders.	Iron	70-74	insulin	Homo sapiens	34-41
10772765-0	2000	Iron regulation of transferrin synthesis in the human hepatoma cell line HepG2.	Iron	0-4	transferrin	Homo sapiens	19-30
10772765-1	2000	In human beings, serum transferrin levels increase during iron deficiency and decrease with iron overload.	Iron	58-62	transferrin	Homo sapiens	23-34
10772765-3	2000	In previous studies, iron was shown to suppress the expression of chimeric human transferrin genes in livers of transgenic mice.	Iron	21-25	transferrin	Homo sapiens	81-92
10772765-4	2000	The goal of this study was to determine if iron suppresses intact endogenous human transferrin synthesis by testing the effects of changes in iron levels on synthesis of transferrin in a human hepatoma cell line HepG2.	Iron	43-47	transferrin	Homo sapiens	83-94
10772765-4	2000	The goal of this study was to determine if iron suppresses intact endogenous human transferrin synthesis by testing the effects of changes in iron levels on synthesis of transferrin in a human hepatoma cell line HepG2.	Iron	142-146	transferrin	Homo sapiens	170-181
10772765-5	2000	In HepG2 cells, normalized(35)S-metabolically labeled transferrin synthesis was consistently less following iron treatment with hemin or ferric citrate, than following treatment with an iron-chelator deferroxamine.	Iron	108-112	transferrin	Homo sapiens	54-65
10772765-5	2000	In HepG2 cells, normalized(35)S-metabolically labeled transferrin synthesis was consistently less following iron treatment with hemin or ferric citrate, than following treatment with an iron-chelator deferroxamine.	Iron	186-190	transferrin	Homo sapiens	54-65
10772765-6	2000	Thus, this study provides new evidence that iron can regulate synthesis of intact endogenous human transferrin.	Iron	44-48	transferrin	Homo sapiens	99-110
10620537-1	2000	Intravenous iron is required by most dialysis patients receiving erythropoietin (EPO) to maintain an adequate hematocrit.	Iron	12-16	erythropoietin	Homo sapiens	65-79
10620537-1	2000	Intravenous iron is required by most dialysis patients receiving erythropoietin (EPO) to maintain an adequate hematocrit.	Iron	12-16	erythropoietin	Homo sapiens	81-84
10620537-4	2000	Each of the iron products increases the efficacy of EPO use in anemia management.	Iron	12-16	erythropoietin	Homo sapiens	52-55
10755318-18	2000	DPPE inhibits testosterone metabolism by interacting at two sites on CYP3A4, the first correlating with its K(S) value to bind the substrate site and the second, with its EC50 value to enhance HA binding to the heme iron.	Iron	216-220	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-75
10953960-0	2000	Transferrin saturation phenotype and HFE genotype screening for hemochromatosis and primary iron overload: predictions from a model based on national, racial, and ethnic group composition in central Alabama.	Iron	92-96	transferrin	Homo sapiens	0-11
10865941-9	2000	The cellular activators TNF-alpha or LPS had little effect on Tf turnover, but they accelerated Fe uptake in both endothelial cell types.	Iron	96-98	tumor necrosis factor	Mus musculus	24-33
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	46-50	transferrin	Homo sapiens	24-35
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	139-143	transferrin	Homo sapiens	24-35
11145266-8	2000	Iron overload stimulated the production of tumor necrosis factor alpha (TNF-alpha), a major factor of septic shock, in mice upon infection with the bacteria, probably caused by the endotoxin; however, the neutrophils, whose migration is effected by TNF-alpha, appeared to be less active.	Iron	0-4	tumor necrosis factor	Mus musculus	43-70
11701534-2	2000	The familiar proteins of iron transport and storage-transferrin, transferrin receptor, and ferritin-have recently been joined by a host of newly identified proteins that play critical roles in the molecular management of iron homeostasis.	Iron	25-29	transferrin	Homo sapiens	52-63
11701534-2	2000	The familiar proteins of iron transport and storage-transferrin, transferrin receptor, and ferritin-have recently been joined by a host of newly identified proteins that play critical roles in the molecular management of iron homeostasis.	Iron	25-29	transferrin	Homo sapiens	65-76
11205155-8	2000	The possibility that an increased amount of iron may be transported into the SN is supported by data demonstrating that one form of the iron-binding glycoprotein transferrin family, lactotransferrin, is increased in surviving neurons in the SN in the PD brain and that this change is associated with increased numbers of lactotransferrin receptors on neurons and microvessels in the parkinsonian SN.	Iron	44-48	lactotransferrin	Homo sapiens	182-198
11205155-8	2000	The possibility that an increased amount of iron may be transported into the SN is supported by data demonstrating that one form of the iron-binding glycoprotein transferrin family, lactotransferrin, is increased in surviving neurons in the SN in the PD brain and that this change is associated with increased numbers of lactotransferrin receptors on neurons and microvessels in the parkinsonian SN.	Iron	44-48	lactotransferrin	Homo sapiens	321-337
11205155-8	2000	The possibility that an increased amount of iron may be transported into the SN is supported by data demonstrating that one form of the iron-binding glycoprotein transferrin family, lactotransferrin, is increased in surviving neurons in the SN in the PD brain and that this change is associated with increased numbers of lactotransferrin receptors on neurons and microvessels in the parkinsonian SN.	Iron	136-140	lactotransferrin	Homo sapiens	182-198
11205155-8	2000	The possibility that an increased amount of iron may be transported into the SN is supported by data demonstrating that one form of the iron-binding glycoprotein transferrin family, lactotransferrin, is increased in surviving neurons in the SN in the PD brain and that this change is associated with increased numbers of lactotransferrin receptors on neurons and microvessels in the parkinsonian SN.	Iron	136-140	lactotransferrin	Homo sapiens	321-337
10851861-3	2000	In the present study we investigated whether the administration of recombinant human erythropoietin (rHuEpo) recombinant human erythropoietin in combination with iron and folic acid may ameliorate blood indices as an alternative choice to blood transfusion.	Iron	162-166	erythropoietin	Homo sapiens	85-99
11701534-2	2000	The familiar proteins of iron transport and storage-transferrin, transferrin receptor, and ferritin-have recently been joined by a host of newly identified proteins that play critical roles in the molecular management of iron homeostasis.	Iron	221-225	transferrin	Homo sapiens	52-63
11701534-2	2000	The familiar proteins of iron transport and storage-transferrin, transferrin receptor, and ferritin-have recently been joined by a host of newly identified proteins that play critical roles in the molecular management of iron homeostasis.	Iron	221-225	transferrin	Homo sapiens	65-76
11920184-0	2000	Non-transferrin-bound iron in myelodysplastic syndromes: a marker of ineffective erythropoiesis?	Iron	22-26	transferrin	Homo sapiens	4-15
11920184-1	2000	INTRODUCTION: Iron overload is usually observed in patients (even untransfused) with myelodysplastic syndromes (MDS), and contributes towards the generation of low molecular weight iron complexes or non-transferrin-bound iron (NTBI), which in turn favors oxidative DNA damage and consequent apoptosis.	Iron	14-18	transferrin	Homo sapiens	203-214
10930054-6	2000	Analysis of patient urine following administration of OL(1)p53 reveals a 7.5-fold increase in iron excretion at low doses (0.05 mg/kg/h).	Iron	94-98	tumor protein p53	Homo sapiens	59-62
11145266-8	2000	Iron overload stimulated the production of tumor necrosis factor alpha (TNF-alpha), a major factor of septic shock, in mice upon infection with the bacteria, probably caused by the endotoxin; however, the neutrophils, whose migration is effected by TNF-alpha, appeared to be less active.	Iron	0-4	tumor necrosis factor	Mus musculus	72-81
11145266-8	2000	Iron overload stimulated the production of tumor necrosis factor alpha (TNF-alpha), a major factor of septic shock, in mice upon infection with the bacteria, probably caused by the endotoxin; however, the neutrophils, whose migration is effected by TNF-alpha, appeared to be less active.	Iron	0-4	tumor necrosis factor	Mus musculus	249-258
10739246-0	2000	Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron.	Iron	112-116	transferrin	Homo sapiens	72-83
10674272-13	2000	This indicates that TF may have other functions beyond iron transport.	Iron	55-59	transferrin	Rattus norvegicus	20-22
11032356-11	2000	Transferrin saturation and ferritin concentration should be monitored monthly, and sufficient iron provided to maintain transferrin saturation above 20%.	Iron	94-98	transferrin	Homo sapiens	120-131
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	46-50	heme oxygenase 1	Mus musculus	0-3
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	0-3
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	125-128
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	125-128
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	125-128
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	0-3
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	125-128
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	125-128
10974422-5	2000	HO1 regulates the efflux of potentially toxic iron from cells, as iron efflux is deficient in mice with targeted deletion of HO1 (HO1(-/-)), and transfection of HO1 facilitates iron efflux.	Iron	66-70	heme oxygenase 1	Mus musculus	125-128
10955573-27	2000	However, the underlying cause of the significantly increased preoperative ACTH concentrations may be a decreased adrenal reserve, presumably related to age and iron load.	Iron	160-164	proopiomelanocortin	Homo sapiens	74-78
11190004-3	2000	Young and mid-age women who reported (ever) having had "low iron" reported significantly lower mean PCS, MCS and VT scores, and greater prevalence of "constant tiredness" at baseline than women with no history of iron deficiency [Differences: young PCS = -2.2, MCS = -4.8, VT = -8.7; constant tiredness: 67% vs. 45%; mid-age PCS = -1.4, MCS = -3.1, VT = -5.9; constant tiredness: 63% vs. 48%].	Iron	60-64	PCS	Homo sapiens	100-103
10696480-12	1999	These results suggest that (i) the enhancement in toxA expression by ptxR correlates with the enhancement in regA expression; (ii) ptxR affects the expression of the regA P1 and P2 promoters; (iii) ptxR expression precedes its effect on toxA and regA expression; and (iv) unlike toxA and regA, the overall expression of ptxR throughout the growth cycle of PAO1 is not negatively regulated by iron.	Iron	392-396	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	131-135
10611285-8	1999	The data show that sGC acts as an extremely fast, specific, and highly efficient trap for NO and that cleavage of the iron-histidine bond provides the driving force for activation of sGC.	Iron	118-122	sarcoglycan beta	Homo sapiens	19-22
10611285-8	1999	The data show that sGC acts as an extremely fast, specific, and highly efficient trap for NO and that cleavage of the iron-histidine bond provides the driving force for activation of sGC.	Iron	118-122	sarcoglycan beta	Homo sapiens	183-186
10572108-0	1999	HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells.	Iron	18-22	transferrin	Homo sapiens	35-46
10572108-3	1999	A previously identified interaction of HFE and the transferrin receptor suggests a possible regulatory role of HFE in cellular iron absorption.	Iron	127-131	transferrin	Homo sapiens	51-62
10572108-5	1999	We demonstrate that the overproduction of HFE results in decreased iron uptake from diferric transferrin.	Iron	67-71	transferrin	Homo sapiens	93-104
10583252-2	1999	The serum ferritin concentration was increased in all patients and non-transferrin-bound iron (NTBI) was increased in all but one patient.	Iron	89-93	transferrin	Homo sapiens	71-82
10696480-10	1999	In contrast, the accumulation of ptxR mRNA was detected throughout the growth cycle of PAO1-XR under both iron-deficient and iron-sufficient conditions.	Iron	106-110	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	33-37
11005131-1	2000	OBJECTIVE: During pregnancy transferrin plays a key role as an iron transport protein to serve the increased fetal demands of iron.	Iron	63-67	transferrin	Homo sapiens	28-39
10619922-7	1999	After the infusion of 900 mg of iron, transferrin saturation increased and total transferrin decreased so that unsaturated iron bonding capacity decreased as well.	Iron	32-36	transferrin	Homo sapiens	38-49
10619922-7	1999	After the infusion of 900 mg of iron, transferrin saturation increased and total transferrin decreased so that unsaturated iron bonding capacity decreased as well.	Iron	32-36	transferrin	Homo sapiens	81-92
10619922-10	1999	We concluded that the low transferrin may be principally the result of diminished synthesis related to the chronic inflammatory status of hemodialysis patients, which favors production of ferritin, but iron and nutritional status may also influence the blood transferrin concentration.	Iron	202-206	transferrin	Homo sapiens	259-270
10619922-11	1999	These factors make interpretation of transferrin-dependent assessment of body iron stores unreliable and can result in inadequate or overly aggressive iron-replacement therapy.	Iron	78-82	transferrin	Homo sapiens	37-48
10619922-11	1999	These factors make interpretation of transferrin-dependent assessment of body iron stores unreliable and can result in inadequate or overly aggressive iron-replacement therapy.	Iron	151-155	transferrin	Homo sapiens	37-48
10583370-1	1999	A water-soluble iron complex with N-dithiocarboxysarcosine (Fe-DTCS) has been developed as an ESR spin-trapping agent for NO and successfully applied to ESR imaging of endogenous NO production in mice.	Iron	16-20	esterase 5 regulator	Mus musculus	94-97
10583370-1	1999	A water-soluble iron complex with N-dithiocarboxysarcosine (Fe-DTCS) has been developed as an ESR spin-trapping agent for NO and successfully applied to ESR imaging of endogenous NO production in mice.	Iron	16-20	esterase 5 regulator	Mus musculus	153-156
10583370-9	1999	These results suggest that the ESR spin-trapping agent Fe-DTCS inhibits NO synthesis by interfering with the physiological electron flow from NADPH to nNOS heme iron.	Iron	161-165	esterase 5 regulator	Mus musculus	31-34
10591920-7	1999	The binding of rat [(125)I]transferrin could be competitively and specifically inhibited by unlabeled iron-saturated rat and human transferrin, and no difference was found between interaction of rat or human transferrin with this receptor.	Iron	102-106	transferrin	Rattus norvegicus	27-38
10591920-7	1999	The binding of rat [(125)I]transferrin could be competitively and specifically inhibited by unlabeled iron-saturated rat and human transferrin, and no difference was found between interaction of rat or human transferrin with this receptor.	Iron	102-106	transferrin	Homo sapiens	131-142
10591920-7	1999	The binding of rat [(125)I]transferrin could be competitively and specifically inhibited by unlabeled iron-saturated rat and human transferrin, and no difference was found between interaction of rat or human transferrin with this receptor.	Iron	102-106	transferrin	Homo sapiens	131-142
10696480-12	1999	These results suggest that (i) the enhancement in toxA expression by ptxR correlates with the enhancement in regA expression; (ii) ptxR affects the expression of the regA P1 and P2 promoters; (iii) ptxR expression precedes its effect on toxA and regA expression; and (iv) unlike toxA and regA, the overall expression of ptxR throughout the growth cycle of PAO1 is not negatively regulated by iron.	Iron	392-396	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	131-135
10696480-12	1999	These results suggest that (i) the enhancement in toxA expression by ptxR correlates with the enhancement in regA expression; (ii) ptxR affects the expression of the regA P1 and P2 promoters; (iii) ptxR expression precedes its effect on toxA and regA expression; and (iv) unlike toxA and regA, the overall expression of ptxR throughout the growth cycle of PAO1 is not negatively regulated by iron.	Iron	392-396	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	131-135
10587364-1	1999	Transferrin is produced primarily by the liver and is best known as a carrier of iron in the circulation.	Iron	81-85	transferrin	Homo sapiens	0-11
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	121-125	nitric oxide synthase 2	Homo sapiens	206-210
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	127-129	nitric oxide synthase 2	Homo sapiens	206-210
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	172-174	nitric oxide synthase 2	Homo sapiens	206-210
10587364-2	1999	Transferrin is also produced extra-hepatically where it may serve to suppress the generation of reactive oxygen species and act as a growth factor, in addition to its role in the endocytosis of iron.	Iron	194-198	transferrin	Homo sapiens	0-11
10580122-1	1999	Iron regulatory protein 2 (IRP2) is one of the central regulators of iron homeostasis.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	0-25
10693977-0	1999	Aluminum uptake and effects on transferrin mediated iron uptake in primary cultures of rat neurons, astrocytes and oligodendrocytes.	Iron	52-56	transferrin	Rattus norvegicus	31-42
10693977-1	1999	Transferrin (Tf) is known primarily for its role in the transport and cellular uptake of iron (Fe).	Iron	89-93	transferrin	Rattus norvegicus	0-11
10693977-1	1999	Transferrin (Tf) is known primarily for its role in the transport and cellular uptake of iron (Fe).	Iron	95-97	transferrin	Rattus norvegicus	0-11
10624905-6	1999	When rhEPO was supplemented with iron, ZPP fell to 70.4 +/- 20.5 micromol/mol heme, the percentage of hypochromic red cells fell to 14.7 +/- 3.4%; ferritin was unchanged at 771 +/- 62 microg/L and transferrin saturation rose to 20.5 +/- 5.5%.	Iron	33-37	transferrin	Homo sapiens	197-208
10666843-6	1999	Mutations of the HFE-protein alter the affinity of the transferrin receptor for its ligand transferrin and may thus cause an intracellular accumulation of iron.	Iron	155-159	transferrin	Homo sapiens	55-66
10666843-6	1999	Mutations of the HFE-protein alter the affinity of the transferrin receptor for its ligand transferrin and may thus cause an intracellular accumulation of iron.	Iron	155-159	transferrin	Homo sapiens	91-102
10580122-1	1999	Iron regulatory protein 2 (IRP2) is one of the central regulators of iron homeostasis.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	27-31
10580122-2	1999	IRP2 regulates expression of molecules involved in iron metabolism by binding to iron responsive elements (IREs) in the transcripts of those molecules in iron depletion.	Iron	51-55	iron responsive element binding protein 2	Homo sapiens	0-4
10625461-5	1999	Indeed, porphyrin cytochrome c (in which the heme iron ion has been removed) is substantially more ordered than apocytochrome c, having characteristics consistent with a molten globule state.	Iron	50-54	cytochrome c, somatic	Homo sapiens	18-30
10580122-2	1999	IRP2 regulates expression of molecules involved in iron metabolism by binding to iron responsive elements (IREs) in the transcripts of those molecules in iron depletion.	Iron	81-85	iron responsive element binding protein 2	Homo sapiens	0-4
10580122-2	1999	IRP2 regulates expression of molecules involved in iron metabolism by binding to iron responsive elements (IREs) in the transcripts of those molecules in iron depletion.	Iron	81-85	iron responsive element binding protein 2	Homo sapiens	0-4
10580122-3	1999	IRP2 is regulated by the accelerated degradation initiated by the iron-catalyzed oxidation.	Iron	66-70	iron responsive element binding protein 2	Homo sapiens	0-4
10580122-4	1999	Here we report that aluminum antagonizes the iron-induced decrease in IRE binding activity of IRP2.	Iron	45-49	iron responsive element binding protein 2	Homo sapiens	94-98
10580122-5	1999	Aluminum also inhibits iron-induced oxidation of IRP2 in vitro.	Iron	23-27	iron responsive element binding protein 2	Homo sapiens	49-53
10580122-6	1999	These results suggest that aluminum stabilizes IRP2 by interfering with the iron-catalyzed oxidation, which results in perturbation of iron metabolism.	Iron	76-80	iron responsive element binding protein 2	Homo sapiens	47-51
10580122-6	1999	These results suggest that aluminum stabilizes IRP2 by interfering with the iron-catalyzed oxidation, which results in perturbation of iron metabolism.	Iron	135-139	iron responsive element binding protein 2	Homo sapiens	47-51
10547300-0	1999	Transferrin, is a mixed chelate-protein ternary complex involved in the mechanism of iron uptake by serum-transferrin in vitro?	Iron	85-89	transferrin	Homo sapiens	0-11
10556042-2	1999	HFE binds to transferrin receptor (TfR), the receptor used by cells to obtain iron in the form of diferric transferrin (Fe-Tf).	Iron	78-82	transferrin	Homo sapiens	13-24
10547300-10	1999	This implies that the exchange of iron between a chelate and serum-transferrin occurs by a single general mechanism.	Iron	34-38	transferrin	Homo sapiens	67-78
10547300-0	1999	Transferrin, is a mixed chelate-protein ternary complex involved in the mechanism of iron uptake by serum-transferrin in vitro?	Iron	85-89	transferrin	Homo sapiens	106-117
10547300-1	1999	Iron uptake by transferrin from triacetohydroxamatoFe(III) (Fe(AHA)3) in the presence of bicarbonate has been investigated between pH 7 and 8.2.	Iron	0-4	transferrin	Homo sapiens	15-26
10575556-7	1999	Although the dogma is that the myoglobin is the source of iron, recent studies suggest that cytochrome P450 may be an important source of iron in this model.	Iron	138-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-107
10551871-0	1999	Yeast mitochondrial protein, Nfs1p, coordinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron distribution.	Iron	59-63	cysteine desulfurase	Saccharomyces cerevisiae S288C	29-34
10545417-2	1999	We have examined the effects of the iron(III) chelator deferroxamine (DFO) and iron (FeCl(3)) on UVB (290-320 nm)-induced activator protein 1 (AP-1) signaling.	Iron	36-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-141
10545417-2	1999	We have examined the effects of the iron(III) chelator deferroxamine (DFO) and iron (FeCl(3)) on UVB (290-320 nm)-induced activator protein 1 (AP-1) signaling.	Iron	36-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-147
10545417-8	1999	These results indicate that UVB-induced AP-1 activation may be in part due to oxidant effects of UVB and intercellular iron.	Iron	119-123	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-44
10551871-0	1999	Yeast mitochondrial protein, Nfs1p, coordinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron distribution.	Iron	98-102	cysteine desulfurase	Saccharomyces cerevisiae S288C	29-34
10551871-0	1999	Yeast mitochondrial protein, Nfs1p, coordinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron distribution.	Iron	98-102	cysteine desulfurase	Saccharomyces cerevisiae S288C	29-34
10551871-1	1999	Nfs1p is the yeast homolog of the bacterial proteins NifS and IscS, enzymes that release sulfur from cysteine for iron-sulfur cluster assembly.	Iron	114-118	cysteine desulfurase	Saccharomyces cerevisiae S288C	0-5
10551871-2	1999	Here we show that the yeast mitochondrial protein Nfs1p regulates cellular and mitochondrial iron homeostasis.	Iron	93-97	cysteine desulfurase	Saccharomyces cerevisiae S288C	50-55
10551871-3	1999	A strain of Saccharomyces cerevisiae, MA14, with a missense NFS1 allele (I191S) was isolated in a screen for altered iron-dependent gene regulation.	Iron	117-121	cysteine desulfurase	Saccharomyces cerevisiae S288C	60-64
10551871-8	1999	This hypothesis was confirmed by experiments in which expression of wild-type Nfs1p from a regulated galactose-induced promoter was turned off, leading to recapitulation of the iron regulatory phenotypes characteristic of the MA14 mutant.	Iron	177-181	cysteine desulfurase	Saccharomyces cerevisiae S288C	78-83
10587746-5	1999	Serum transferrin receptors, red cell ferritin and red cell zinc protoporphyrin are good indicators of this iron supply to the erythroid marrow for erythropoiesis.	Iron	108-112	transferrin	Homo sapiens	6-17
10587746-6	1999	Since the introduction of recombinant human erythropoietin, it has become apparent that an adequate iron supply to the bone marrow is essential for a satisfactory hematopoietic response.	Iron	100-104	erythropoietin	Homo sapiens	44-58
10575556-11	1999	Recent studies indicate that cytochrome P450 may also be an important source of the catalytic iron in cisplatin nephrotoxicity.	Iron	94-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	29-44
10535879-0	1999	Insulin resistance-associated hepatic iron overload.	Iron	38-42	insulin	Homo sapiens	0-7
10535890-0	1999	More clues to the relationship between hepatic iron and steatosis: An association with insulin resistance?	Iron	47-51	insulin	Homo sapiens	87-94
10544286-2	1999	In Escherichia coli, genes in the ORF1-ORF2-iscS-iscU-iscA-hscB-hsc A-fdx-ORF3 cluster (the isc gene cluster) should be involved in the assembly of the Fe-S cluster since its coexpression with the reporter ferredoxin (Fd) dramatically increases the production of holoFd [Nakamura, M., Saeki, K., and Takahashi, Y.	Iron	152-156	hypothetical protein	Escherichia coli	34-38
10531234-6	1999	In contrast, the ompB1 (tbpB) mutant was capable of utilizing iron from human transferrin, although not to the extent of the parental strain.	Iron	62-66	transferrin	Homo sapiens	78-89
10531234-9	1999	These data suggest that the M. catarrhalis TbpA is necessary for the acquisition of iron from transferrin.	Iron	84-88	transferrin	Homo sapiens	94-105
10730522-7	1999	The correlation between transferrin saturation (TS = serum iron/TIBC x 100) and serum ferritin was shown in the equation of TS = 10.253 In (ferritin) (r = 0.956, p = 0.000).	Iron	59-63	transferrin	Homo sapiens	24-35
10510279-2	1999	These probes, containing a photolabile azido-group and an amino-group on opposite sides of the molecule, were designed for photoaffinty labeling of the cytochrome P450 (CYP) 2B active site cavity differing in distance from the heme iron.	Iron	232-236	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	152-176
10518614-6	1999	These results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well-characterized post-transcriptional control of TfR expression to expand the extent of response to iron deficiency.	Iron	99-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-43
10518614-6	1999	These results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well-characterized post-transcriptional control of TfR expression to expand the extent of response to iron deficiency.	Iron	303-307	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-43
10534512-1	1999	BACKGROUND: Iron balance is critical for adequate erythropoiesis and there remains much debate concerning the optimal timing and dosage of iron therapy for haemodialysis patients receiving recombinant human erythropoietin therapy.	Iron	139-143	erythropoietin	Homo sapiens	207-221
10571078-6	1999	In the HFE-expressing cells the reduction in transferrin-mediated iron incorporation was partially compensated by a approximately 30% increase in non-transferrin iron incorporation from 55Fe-NTA, evident after prolonged, 18 h, incubations.	Iron	66-70	transferrin	Homo sapiens	45-56
10571078-6	1999	In the HFE-expressing cells the reduction in transferrin-mediated iron incorporation was partially compensated by a approximately 30% increase in non-transferrin iron incorporation from 55Fe-NTA, evident after prolonged, 18 h, incubations.	Iron	162-166	transferrin	Homo sapiens	45-56
10571078-7	1999	The findings indicate that HFE binding to transferrin receptor reduces cellular iron availability and regulates the balance between transferrin-mediated and non-transferrin-mediated cellular iron incorporation.	Iron	80-84	transferrin	Homo sapiens	42-53
10571078-7	1999	The findings indicate that HFE binding to transferrin receptor reduces cellular iron availability and regulates the balance between transferrin-mediated and non-transferrin-mediated cellular iron incorporation.	Iron	191-195	transferrin	Homo sapiens	42-53
10518614-0	1999	HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation.	Iron	72-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
10518614-1	1999	Treatment with iron chelators mimics hypoxic induction of the hypoxia inducible factor (HIF-1) which activates transcription by binding to hypoxia responsive elements (HRE).	Iron	15-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-93
10518614-2	1999	We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation.	Iron	150-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-29
10518614-2	1999	We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation.	Iron	178-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-29
10542324-4	1999	The similarity between the N-terminal and the C-terminal domains of MTf is much higher than that of the other transferrins, although the five amino acid residues required for iron binding were not conserved in the C-terminal domain of MTf in contrast to the conservation of these residues in both domains of the other transferrins.	Iron	175-179	melanotransferrin	Mus musculus	68-71
10531064-1	1999	The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome.	Iron	137-141	transferrin	Homo sapiens	4-15
10531064-1	1999	The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome.	Iron	214-218	transferrin	Homo sapiens	4-15
10510285-6	1999	Antioxidants or iron chelators which prevent lipid peroxidation, prevented the degradation of CYP2E1 by the cytosolic fraction.	Iron	16-20	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	94-100
10506125-6	1999	Hemin/hydrogen peroxide similarly induced aggregation of alpha-synuclein, and both cytochrome c/hydrogen peroxide- and hemin/hydrogen peroxide-induced aggregation of alpha-synuclein was partially inhibited by treatment with iron chelator deferoxisamine.	Iron	224-228	cytochrome c, somatic	Homo sapiens	83-95
10506125-7	1999	This indicates that iron-catalyzed oxidative reaction mediated by cytochrome c/hydrogen peroxide might be critically involved in promoting alpha-synuclein aggregation.	Iron	20-24	cytochrome c, somatic	Homo sapiens	66-78
10510058-14	1999	Iron loading peaked 2 to 10 hours after bypass and was more severe in the restrictive group (peak transferrin saturation: restrictive group 83.9+/-13.0%, nonrestrictive group 58.3+/-16.2%, P=0.05; minimum total iron-binding capacity: restrictive group 0.59+/-0.21%, nonrestrictive group 0.76+/-0.06%, P=0.04; minimum iron-binding antioxidant activity to oxyorganic radicals: restrictive group 9.	Iron	0-4	transferrin	Homo sapiens	98-109
10521251-8	1999	UV-vis measurements indicate that the (1)H NMR detected changes in the conformation of the Fe(III)-insulin hexamer are accompanied by a change in the electronic structure of the iron site.	Iron	178-182	insulin	Homo sapiens	99-106
10510058-16	1999	CONCLUSIONS: After tetralogy of Fallot repair, acute restrictive RV physiology is associated with greater intraoperative myocardial injury and postoperative oxidative stress with severe iron loading of transferrin.	Iron	186-190	transferrin	Homo sapiens	202-213
10516370-4	1999	Erythropoietin-stimulated red blood cell (RBC) production can quickly decrease the labile cellular iron pool and reduce serum ferritin, unless supplemental iron is supplied.	Iron	99-103	erythropoietin	Homo sapiens	0-14
10529216-0	1999	Significance of metal ions in galactose-1-phosphate uridylyltransferase: an essential structural zinc and a nonessential structural iron.	Iron	132-136	galactose-1-phosphate uridylyltransferase	Homo sapiens	30-71
10529216-2	1999	GalT is a metalloenzyme containing 1.2 mol of zinc and 0.7 mol of iron/mol of subunits [Ruzicka, F. J., Wedekind, J. E., Kim, J., Rayment, I., and Frey, P. A.	Iron	66-70	galactose-1-phosphate uridylyltransferase	Homo sapiens	0-4
10692770-4	1999	Other patients usually present with another cause of iron overload, such as insulin resistance, alcoholic liver disease or liver cirrhosis.	Iron	53-57	insulin	Homo sapiens	76-83
10516370-4	1999	Erythropoietin-stimulated red blood cell (RBC) production can quickly decrease the labile cellular iron pool and reduce serum ferritin, unless supplemental iron is supplied.	Iron	156-160	erythropoietin	Homo sapiens	0-14
10522550-10	1999	Body iron can enter intestinal cells from plasma via basolateral membranes containing the classical transferrin receptor pathway with a high affinity for holotransferrin.	Iron	5-9	transferrin	Homo sapiens	100-111
10516370-6	1999	This is particularly true in patients receiving erythropoietin, in which the stimulated erythropoiesis requires extra iron supplies.	Iron	118-122	erythropoietin	Homo sapiens	48-62
10522550-13	1999	Unlike the absorptive surface of intestinal cells, most other cells possess transferrin receptors on their surfaces and the vast majority of iron entering these cells is transferrin associated.	Iron	141-145	transferrin	Homo sapiens	170-181
10522550-14	1999	There seem to be 2 distinct pathways by which transferrin iron enters nonintestinal cells.	Iron	58-62	transferrin	Homo sapiens	46-57
10522550-15	1999	In the classical clathrin-coated pitendosome pathway, iron accompanies transferrin into the cell to enter a vesicle, which releases the iron to the cytosol with acidification (high affinity, low capacity).	Iron	54-58	transferrin	Homo sapiens	71-82
10522550-15	1999	In the classical clathrin-coated pitendosome pathway, iron accompanies transferrin into the cell to enter a vesicle, which releases the iron to the cytosol with acidification (high affinity, low capacity).	Iron	136-140	transferrin	Homo sapiens	71-82
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	14-18	iron responsive element binding protein 2	Homo sapiens	129-133
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	14-18	aconitase 2	Homo sapiens	306-329
10516373-5	1999	With the introduction of recombinant human erythropoietin therapy for hemodialysis patients, the need for red blood cell transfusions has been reduced and iron overload occurs much less frequently.	Iron	155-159	erythropoietin	Homo sapiens	43-57
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	iron responsive element binding protein 2	Homo sapiens	129-133
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	aconitase 2	Homo sapiens	306-329
10519507-0	1999	Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels.	Iron	127-131	BCL2 like 1	Homo sapiens	18-24
10519507-11	1999	Overexpression of bcl-xL was associated with elevated glutathione levels, elevated ferritin levels, and increased amounts of iron.	Iron	125-129	BCL2 like 1	Homo sapiens	18-24
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	iron responsive element binding protein 2	Homo sapiens	129-133
10516373-6	1999	Several recent studies have indicated that iron overload, which is suspected in the presence of high serum ferritin levels, may no longer be a significant risk factor for infection in hemodialysis patients receiving erythropoietin therapy.	Iron	43-47	erythropoietin	Homo sapiens	216-230
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	aconitase 2	Homo sapiens	306-329
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	iron responsive element binding protein 2	Homo sapiens	129-133
10516375-2	1999	It is also increasingly recognized that IV iron can enhance the response to epoetin, even in iron-replete patients.	Iron	43-47	erythropoietin	Homo sapiens	76-83
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	aconitase 2	Homo sapiens	306-329
10522552-5	1999	Differences in iron metabolism and in genes for 5-aminolevulinic acid synthase (ALA-S, the first enzyme in heme biosynthesis) are responsible for the differences in regulation and rates of heme synthesis in erythroid and nonerythroid cells.	Iron	15-19	5'-aminolevulinate synthase 1	Homo sapiens	80-85
10516375-9	1999	This simple, practical IV iron dosing policy resulted in dramatic savings in epoetin dosage and cost with no significant adverse effects.	Iron	26-30	erythropoietin	Homo sapiens	77-84
10522552-7	1999	Because the 5"-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells.	Iron	86-90	5'-aminolevulinate synthase 1	Homo sapiens	61-66
10498610-5	1999	Analysis of the intracellular distribution of incorporated iron revealed that in IFN-gamma/LPS-activated macrophages there was a decreased amount and proportion of ferritin-bound iron and a compensatory increase in insoluble iron, which probably consists mainly of iron bound to intracellular organelles.	Iron	59-63	interferon gamma	Mus musculus	81-90
10522552-7	1999	Because the 5"-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells.	Iron	196-200	5'-aminolevulinate synthase 1	Homo sapiens	61-66
10522552-7	1999	Because the 5"-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells.	Iron	196-200	5'-aminolevulinate synthase 1	Homo sapiens	61-66
10522552-9	1999	On the other hand, in erythroid cells, heme does not inhibit either the activity or the synthesis of ALA-S but does inhibit cellular iron acquisition from transferrin without affecting its utilization for heme synthesis.	Iron	133-137	transferrin	Homo sapiens	155-166
10522552-10	1999	This negative feedback is likely to explain the mechanism by which the availability of transferrin iron limits heme synthesis rate.	Iron	99-103	transferrin	Homo sapiens	87-98
10522553-5	1999	The most sensitive screening test for hemochromatosis is saturation of the transferrin with iron; a fasting value greater than 50% is strongly suggestive of the disease.	Iron	92-96	transferrin	Homo sapiens	75-86
10498610-5	1999	Analysis of the intracellular distribution of incorporated iron revealed that in IFN-gamma/LPS-activated macrophages there was a decreased amount and proportion of ferritin-bound iron and a compensatory increase in insoluble iron, which probably consists mainly of iron bound to intracellular organelles.	Iron	179-183	interferon gamma	Mus musculus	81-90
10498610-5	1999	Analysis of the intracellular distribution of incorporated iron revealed that in IFN-gamma/LPS-activated macrophages there was a decreased amount and proportion of ferritin-bound iron and a compensatory increase in insoluble iron, which probably consists mainly of iron bound to intracellular organelles.	Iron	179-183	interferon gamma	Mus musculus	81-90
10498610-5	1999	Analysis of the intracellular distribution of incorporated iron revealed that in IFN-gamma/LPS-activated macrophages there was a decreased amount and proportion of ferritin-bound iron and a compensatory increase in insoluble iron, which probably consists mainly of iron bound to intracellular organelles.	Iron	179-183	interferon gamma	Mus musculus	81-90
10498610-6	1999	Finally, although NO released by IFN-gamma/LPS-activated macrophages increased the iron-responsive element (IRE)-binding activity of both IRP1 and IRP2, IFN-gamma treatment decreased IRP2 activity in an NO-independent manner.	Iron	83-87	interferon gamma	Mus musculus	33-42
10498610-6	1999	Finally, although NO released by IFN-gamma/LPS-activated macrophages increased the iron-responsive element (IRE)-binding activity of both IRP1 and IRP2, IFN-gamma treatment decreased IRP2 activity in an NO-independent manner.	Iron	83-87	interferon gamma	Mus musculus	153-162
10498610-7	1999	This study demonstrates that the effect of IFN-gamma and/or LPS on macrophage iron metabolism is complex, and is not entirely due to either NO-or to IRP-mediated mechanisms.	Iron	78-82	interferon gamma	Mus musculus	43-52
10529482-3	1999	Changing the iron availability resulted in alterations in plasma and cerebrospinal fluid (CSF) levels of transferrin and iron.	Iron	13-17	transferrin	Rattus norvegicus	105-116
10660486-0	1999	The effect of transferrin polymorphisms on iron metabolism.	Iron	43-47	transferrin	Homo sapiens	14-25
11213255-4	1999	Furthermore, a strict requirement for plant ferritin synthesis regulation is attested to by alterations of the photosynthetic apparatus and of iron homeostasis in transgenic tobaccos overexpressing these proteins.	Iron	143-147	ferritin-1, chloroplastic	Nicotiana tabacum	44-52
10543327-14	1999	Intensified iron substitution to patients with elevated sTf-R concentrations may considerably improve the cost efficacy of EPO treatment.	Iron	12-16	erythropoietin	Homo sapiens	123-126
10498610-2	1999	Stimulation of macrophages with interferon-gamma (IFN-gamma) and/or lipopolysaccharide (LPS) decreased Fe uptake from transferrin (Tf), and there was a concomitant downregulation of TfR expression.	Iron	103-105	interferon gamma	Mus musculus	32-48
10498610-2	1999	Stimulation of macrophages with interferon-gamma (IFN-gamma) and/or lipopolysaccharide (LPS) decreased Fe uptake from transferrin (Tf), and there was a concomitant downregulation of TfR expression.	Iron	103-105	interferon gamma	Mus musculus	50-59
10529482-4	1999	The iron-binding capacity of transferrin in CSF was exceeded in normal and iron-overloaded rats.	Iron	4-8	transferrin	Rattus norvegicus	29-40
10529482-4	1999	The iron-binding capacity of transferrin in CSF was exceeded in normal and iron-overloaded rats.	Iron	75-79	transferrin	Rattus norvegicus	29-40
10497206-4	1999	In the structure, both empty iron binding clefts are in the open conformation, lending weight to the theory that Fe(3+) binding or release in transferrin proceeds via a mechanism that involves domain opening and closure.	Iron	29-33	transferrin	Homo sapiens	142-153
10552775-3	1999	EDTA inhibited lipid oxidation in all the emulsions, and apo-transferrin inhibited oxidation in the Tween 20-stabilized emulsions at pH 7.0, suggesting that continuous-phase iron was an active prooxidant.	Iron	174-178	transferrin	Homo sapiens	61-72
10582342-1	1999	The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to mediate cellular uptake of iron from a plasma glycoprotein, transferrin.	Iron	121-125	transferrin	Homo sapiens	4-15
10582342-2	1999	Iron uptake from transferrin involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	17-28
10582342-2	1999	Iron uptake from transferrin involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	53-64
10582342-2	1999	Iron uptake from transferrin involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	53-64
10582342-2	1999	Iron uptake from transferrin involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	53-64
10582342-2	1999	Iron uptake from transferrin involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis and the release of iron from the protein by a decrease in endosomal pH.	Iron	205-209	transferrin	Homo sapiens	17-28
10582342-5	1999	In proliferating nonerythroid cells the expression of transferrin receptors is negatively regulated post-transcriptionally by intracellular iron through iron responsive elements (IREs) in the 3" untranslated region of transferrin receptor mRNA.	Iron	140-144	transferrin	Homo sapiens	54-65
10582342-5	1999	In proliferating nonerythroid cells the expression of transferrin receptors is negatively regulated post-transcriptionally by intracellular iron through iron responsive elements (IREs) in the 3" untranslated region of transferrin receptor mRNA.	Iron	140-144	transferrin	Homo sapiens	218-229
10582342-5	1999	In proliferating nonerythroid cells the expression of transferrin receptors is negatively regulated post-transcriptionally by intracellular iron through iron responsive elements (IREs) in the 3" untranslated region of transferrin receptor mRNA.	Iron	153-157	transferrin	Homo sapiens	54-65
10582342-5	1999	In proliferating nonerythroid cells the expression of transferrin receptors is negatively regulated post-transcriptionally by intracellular iron through iron responsive elements (IREs) in the 3" untranslated region of transferrin receptor mRNA.	Iron	153-157	transferrin	Homo sapiens	218-229
10582342-6	1999	IREs are recognized by specific cytoplasmic proteins (IRPs; iron regulatory proteins) that, in the absence of iron in the labile pool, bind to the IREs of transferrin receptor mRNA, preventing its degradation.	Iron	60-64	transferrin	Homo sapiens	155-166
10582342-7	1999	On the other hand, the expansion of the labile iron pool leads to a rapid degradation of transferrin receptor mRNA that is not protected since IRPs are not bound to it.	Iron	47-51	transferrin	Homo sapiens	89-100
10469492-0	1999	Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin.	Iron	40-44	transferrin	Homo sapiens	22-33
10582342-8	1999	However, some cells and tissues with specific requirements for iron probably evolved mechanisms that can override the IRE/IRP-dependent control of transferrin receptor expression.	Iron	63-67	transferrin	Homo sapiens	147-158
10582342-9	1999	Erythroid cells, which are the most avid consumers of iron in the organism, use a transcriptional mechanism to maintain very high transferrin receptor levels.	Iron	54-58	transferrin	Homo sapiens	130-141
10469492-0	1999	Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin.	Iron	40-44	transferrin	Homo sapiens	76-87
10469492-1	1999	Non-transferrin-bound iron (NTBI) has been reported to be associated with several clinical states such as thalassemia, hemochromatosis, and in patients receiving chemotherapy.	Iron	22-26	transferrin	Homo sapiens	4-15
10469492-4	1999	NTA (80 mM) removes all forms of NTBI, while only mobilizing a small fraction of the iron bound to both transferrin and ferritin.	Iron	85-89	transferrin	Homo sapiens	104-115
10469492-10	1999	In such cases, to avoid in vitro donation of iron onto the vacant sites of transferrin, sodium-tris-carbonatocobaltate(III) can be added to block the free iron binding sites on transferrin.	Iron	155-159	transferrin	Homo sapiens	177-188
10971835-4	1999	The body has the capacity to reduce the iron availability to be consumed by infectious elements by proteins such as transferrin and lactoferrin.	Iron	40-44	transferrin	Homo sapiens	116-127
10471599-2	1999	Iron in the lower respiratory tract may be free, ferritin bound (from which iron can be reductively mobilized), or transferrin bound (which generally prevents iron mobilization).	Iron	0-4	transferrin	Homo sapiens	115-126
10471599-11	1999	Iron-treated A549 cells synthesized almost entirely L-ferritin whereas exposure to TNF-alpha with iron caused a dose-dependent increase in accumulation of H-type ferritin.	Iron	98-102	tumor necrosis factor	Homo sapiens	83-92
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	49-53	transferrin	Homo sapiens	70-81
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	49-53	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	49-53	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	49-53	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	171-175	transferrin	Homo sapiens	134-145
10509769-3	1999	Iron status was determined by a combination of haemoglobin, serum ferritin and transferrin saturation.	Iron	0-4	transferrin	Homo sapiens	79-90
11096718-10	1999	Determination of iron status is the most important initial laboratory evaluation in patients with RLS.	Iron	17-21	RLS1	Homo sapiens	98-101
10471146-1	1999	We investigated the usefulness of membrane grown human term trophoblast cells in transferrin-mediated iron transfer studies.	Iron	102-106	transferrin	Homo sapiens	81-92
10471146-13	1999	A new experimental design enabled us to demonstrate that indeed the rate of transferrin-mediated iron is in excess over iron accumulation.	Iron	97-101	transferrin	Homo sapiens	76-87
10471146-13	1999	A new experimental design enabled us to demonstrate that indeed the rate of transferrin-mediated iron is in excess over iron accumulation.	Iron	120-124	transferrin	Homo sapiens	76-87
10490274-8	1999	The Ginkgo biloba extract (EGb 761), the neurosteroid dehydroepiandrosterone (DHEA) and human recombinant apoE3 (hapoE3rec) were able to protect control, AD epsilon3/epsilon3 and epsilon3/epsilon4 cases against hydrogen peroxide/iron-induced LPO, while hapoE4rec was completely ineffective.	Iron	229-233	apolipoprotein E	Homo sapiens	106-111
10477157-1	1999	Recombinant epoetin therapy and correction of the chronic anemia of renal failure have greatly reduced the number of red cell transfusions and hence the propensity to iron overload.	Iron	167-171	erythropoietin	Homo sapiens	12-19
10482313-3	1999	Because FRE1 is required for iron uptake in yeast, we hypothesized that flavocytochrome b might serve a similar function in human phagocytes and thus provide a mechanism for the transferrin-independent iron acquisition observed in myeloid cells.	Iron	29-33	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	8-12
10430173-10	1999	A disturbance in iron homeostasis due to alterations in the transferrin receptor and ferritin may explain the hypochromic-microcytic anemia and the accumulation of nonferritin iron in the mitochondria in some individuals after chloramphenicol therapy.	Iron	17-21	transferrin	Homo sapiens	60-71
10430173-10	1999	A disturbance in iron homeostasis due to alterations in the transferrin receptor and ferritin may explain the hypochromic-microcytic anemia and the accumulation of nonferritin iron in the mitochondria in some individuals after chloramphenicol therapy.	Iron	176-180	transferrin	Homo sapiens	60-71
10482313-3	1999	Because FRE1 is required for iron uptake in yeast, we hypothesized that flavocytochrome b might serve a similar function in human phagocytes and thus provide a mechanism for the transferrin-independent iron acquisition observed in myeloid cells.	Iron	202-206	transferrin	Homo sapiens	178-189
10482313-3	1999	Because FRE1 is required for iron uptake in yeast, we hypothesized that flavocytochrome b might serve a similar function in human phagocytes and thus provide a mechanism for the transferrin-independent iron acquisition observed in myeloid cells.	Iron	202-206	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	8-12
10468587-11	1999	We suggest that NFU1 and ISU1 gene products play a role in iron homeostasis, perhaps in assembly, insertion, and/or repair of mitochondrial Fe-S clusters.	Iron	59-63	Nfu1p	Saccharomyces cerevisiae S288C	16-20
10554633-15	1999	CONCLUSIONS: Indirect measurements of iron status (serum ferritin concentration and transferrin saturation) are useful in the diagnosis of African dietary iron overload.	Iron	38-42	transferrin	Homo sapiens	84-95
10554633-15	1999	CONCLUSIONS: Indirect measurements of iron status (serum ferritin concentration and transferrin saturation) are useful in the diagnosis of African dietary iron overload.	Iron	155-159	transferrin	Homo sapiens	84-95
10522369-0	1999	[Carbohydrate-deficient transferrin (CDT) is modified by iron status: further reservations regarding the value of a new alcohol marker?	Iron	57-61	transferrin	Homo sapiens	24-35
10469381-9	1999	Among iron exchange parameters, sTfR is the best predictor of %HYPO, followed by Tf saturation, SI, and ferritin.	Iron	6-10	transferrin	Homo sapiens	33-35
10468587-11	1999	We suggest that NFU1 and ISU1 gene products play a role in iron homeostasis, perhaps in assembly, insertion, and/or repair of mitochondrial Fe-S clusters.	Iron	140-144	Nfu1p	Saccharomyces cerevisiae S288C	16-20
10444519-0	1999	Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity.	Iron	37-41	tumor necrosis factor	Homo sapiens	11-20
10444519-0	1999	Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity.	Iron	37-41	interleukin 1 beta	Homo sapiens	25-33
10444519-1	1999	Extracellular iron, which is predominantly bound by transferrin, is present in low concentrations within alveolar structures, and concentrations are increased in various pulmonary disorders.	Iron	14-18	transferrin	Homo sapiens	52-63
10444519-4	1999	The cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta may alter iron metabolism by alveolar cells.	Iron	85-89	tumor necrosis factor	Homo sapiens	14-47
10444519-4	1999	The cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta may alter iron metabolism by alveolar cells.	Iron	85-89	interleukin 1 beta	Homo sapiens	52-74
10444519-5	1999	In this study, we assessed the effects of TNF-alpha and IL-1beta on iron metabolism with a cell line with properties of type 2 alveolar epithelial cells (A549) exposed to non-transferrin-bound (NTBI; FeSO(4)) or transferrin-bound (TBI) iron.	Iron	68-72	interleukin 1 beta	Homo sapiens	56-64
10444519-12	1999	These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis.	Iron	61-65	tumor necrosis factor	Homo sapiens	29-38
10444519-12	1999	These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis.	Iron	61-65	interleukin 1 beta	Homo sapiens	43-51
10444519-13	1999	Enhanced iron uptake induced by TNF-alpha and NTBI was also associated with increased cytotoxicity to A549 cells.	Iron	9-13	tumor necrosis factor	Homo sapiens	32-41
10458132-7	1999	Oral iron was given to patients receiving erythropoietin.	Iron	5-9	erythropoietin	Homo sapiens	42-56
10490243-1	1999	Cardiopulmonary bypass surgery is associated with the release of low molecular mass iron, which increases the saturation of plasma transferrin to over 50% in all adult patients treated.	Iron	84-88	transferrin	Homo sapiens	131-142
11207750-7	1999	Strain CKB can also couple chlorate reduction to the oxidation of ferrous iron, sulphide, or the reduced form of the humic substances analogue 2,6-anthrahydroquinone disulphonate.	Iron	66-78	creatine kinase B	Homo sapiens	7-10
10490243-2	1999	In a significant minority, however plasma transferrin becomes 100% iron saturated and non-transferrin bound iron can be detected in the plasma.	Iron	67-71	transferrin	Homo sapiens	42-53
10490243-3	1999	An iron-saturated transferrin is also a common physiological finding in normal term and pre-term infants at a time when their plasma antioxidants, which protect against iron toxicity and radical scavenging, are profoundly different from those seen in adults.	Iron	3-7	transferrin	Homo sapiens	18-29
10490243-3	1999	An iron-saturated transferrin is also a common physiological finding in normal term and pre-term infants at a time when their plasma antioxidants, which protect against iron toxicity and radical scavenging, are profoundly different from those seen in adults.	Iron	169-173	transferrin	Homo sapiens	18-29
10528321-1	1999	INTRODUCTION: Haptoglobin is a transport protein and protects organism against iron loss and it should be involved in central nervous system infectious process.	Iron	79-83	haptoglobin	Homo sapiens	14-25
10409623-2	1999	Transferrin receptor (TfR) plays a major role in cellular iron uptake through binding and internalizing a carrier protein transferrin (Tf).	Iron	58-62	transferrin	Homo sapiens	122-133
10409623-2	1999	Transferrin receptor (TfR) plays a major role in cellular iron uptake through binding and internalizing a carrier protein transferrin (Tf).	Iron	58-62	transferrin	Homo sapiens	22-24
10409623-11	1999	Also, these cells had a marked increase in Tf-bound (55)Fe uptake.	Iron	56-58	transferrin	Homo sapiens	43-45
10409623-12	1999	Taken together, TfR2-alpha may be a second transferrin receptor that can mediate cellular iron transport.	Iron	90-94	transferrin	Homo sapiens	43-54
10459632-10	1999	In the second experiment, iron-treated rats had an increased number of GST-7,7-positive foci compared to controls.	Iron	26-30	glutathione S-transferase pi 1	Rattus norvegicus	71-78
11045146-3	1999	Measurement of circulating serum transferrin receptor level was a sensitive indicator of iron depletion as well as a helpful parameter in differential diagnosis between iron deficiency and anemia of chronic disease where circulating transferrin receptor level was not elevated.	Iron	89-93	transferrin	Homo sapiens	33-44
10499291-1	1999	The acetylation of the hemeundecapeptide prepared by proteolysis of cytochrome c yields a species di(N-acetyl)-microperoxidase-11, NAcMP11, that is monomeric in aqueous solution at least for concentrations below 20 microM, in contrast to MP11 itself, which aggregates because of intermolecular coordination of Fe(III) by the N-terminal amino group or the amino group of the side chain of Lys-13.	Iron	310-312	cytochrome c, somatic	Homo sapiens	68-80
10499291-1	1999	The acetylation of the hemeundecapeptide prepared by proteolysis of cytochrome c yields a species di(N-acetyl)-microperoxidase-11, NAcMP11, that is monomeric in aqueous solution at least for concentrations below 20 microM, in contrast to MP11 itself, which aggregates because of intermolecular coordination of Fe(III) by the N-terminal amino group or the amino group of the side chain of Lys-13.	Iron	310-312	non-compact myelin associated protein	Homo sapiens	134-138
10377239-3	1999	This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecules mediating iron uptake and cell adhesion.	Iron	117-121	transferrin	Homo sapiens	29-40
10401011-5	1999	Twelve patients on maintenance iron therapy (25 to 100 mg/wk; TSAT, 30% to 50%) had a statistically significant decrease in the amount of recombinant human erythropoietin (rHuEPO) needed to maintain hemoglobin (Hb) levels between 10 and 11 g/dL compared with 12 patients receiving intermittent need-based dosing, an effect that persisted from week 16 to week 72 of the study.	Iron	31-35	erythropoietin	Homo sapiens	156-170
10484662-2	1999	Iron regulatory proteins (IRP1 and IRP2), two post-transcriptional regulators of gene expression, are particularly sensitive to NO synthesis and to oxidative stress.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	35-39
10405761-4	1999	Tyrosine phosphorylation of Bcr by Fes greatly enhanced the binding of Bcr to the SH2 domains of multiple signalling molecules in vitro, including Grb-2, Ras GTPase activating protein, phospholipase C-gamma, the 85,000 M(r) subunit of phosphatidylinositol 3"-kinase, and the Abl tyrosine kinase.	Iron	35-38	growth factor receptor bound protein 2	Homo sapiens	147-152
10429185-0	1999	The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake.	Iron	116-120	transferrin	Homo sapiens	98-109
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	157-159	transferrin	Homo sapiens	206-217
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	198-200	transferrin	Homo sapiens	206-217
10373684-2	1999	The classical concept for iron uptake into mammalian cells has been the endocytosis of transferrin-bound Fe3+ by the transferrin receptor.	Iron	26-30	transferrin	Homo sapiens	87-98
10440210-10	1999	CONCLUSION: The combined findings of this study were that, in the dietary iron-loaded rat model, increased iron stores were localized to periportal hepatocytes and that these same hepatocytes also had increased ferritin, transferrin receptor and transferrin protein expression.	Iron	74-78	transferrin	Rattus norvegicus	221-232
10440210-10	1999	CONCLUSION: The combined findings of this study were that, in the dietary iron-loaded rat model, increased iron stores were localized to periportal hepatocytes and that these same hepatocytes also had increased ferritin, transferrin receptor and transferrin protein expression.	Iron	107-111	transferrin	Rattus norvegicus	221-232
10424284-0	1999	Differential response of non-transferrin bound iron uptake in rat liver cells on long-term and short-term treatment with iron.	Iron	47-51	transferrin	Rattus norvegicus	29-40
10424284-0	1999	Differential response of non-transferrin bound iron uptake in rat liver cells on long-term and short-term treatment with iron.	Iron	121-125	transferrin	Rattus norvegicus	29-40
10424284-1	1999	BACKGROUND: Uptake of non-transferrin-bound iron by the liver is important as a clearance mechanism in iron overload.	Iron	44-48	transferrin	Rattus norvegicus	26-37
10424284-1	1999	BACKGROUND: Uptake of non-transferrin-bound iron by the liver is important as a clearance mechanism in iron overload.	Iron	103-107	transferrin	Rattus norvegicus	26-37
10424284-3	1999	This study compares the influence of long-term and short-term depletion and loading of hepatocytes with iron on the uptake of non-transferrin bound iron, its affinity, specificity and the interaction with the transferrin-mediated pathways.	Iron	104-108	transferrin	Rattus norvegicus	130-141
10424284-3	1999	This study compares the influence of long-term and short-term depletion and loading of hepatocytes with iron on the uptake of non-transferrin bound iron, its affinity, specificity and the interaction with the transferrin-mediated pathways.	Iron	104-108	transferrin	Rattus norvegicus	209-220
10424284-3	1999	This study compares the influence of long-term and short-term depletion and loading of hepatocytes with iron on the uptake of non-transferrin bound iron, its affinity, specificity and the interaction with the transferrin-mediated pathways.	Iron	148-152	transferrin	Rattus norvegicus	130-141
10424284-3	1999	This study compares the influence of long-term and short-term depletion and loading of hepatocytes with iron on the uptake of non-transferrin bound iron, its affinity, specificity and the interaction with the transferrin-mediated pathways.	Iron	148-152	transferrin	Rattus norvegicus	209-220
10424284-6	1999	Uptake of non-transferrin bound iron was assayed from ferric citrate and from ferric diethylene triammine pentaacetate.	Iron	32-36	transferrin	Rattus norvegicus	14-25
10424284-7	1999	RESULTS: Uptake of non-transferrin-bound iron in hepatocytes could be seen as consisting of a high-affinity (Km=600 nM) and a low-affinity component.	Iron	41-45	transferrin	Rattus norvegicus	23-34
10424284-12	1999	In both cases, uptake of non-transferrin bound iron was inhibited by apotransferrin.	Iron	47-51	transferrin	Rattus norvegicus	29-40
10424284-13	1999	CONCLUSIONS: Non-transferrin bound iron uptake in liver cells is apparently regulated by the iron status of the liver.	Iron	35-39	transferrin	Rattus norvegicus	17-28
10424284-13	1999	CONCLUSIONS: Non-transferrin bound iron uptake in liver cells is apparently regulated by the iron status of the liver.	Iron	93-97	transferrin	Rattus norvegicus	17-28
10417735-10	1999	The Nramp2 protein was subsequently shown to be the major transferrin-independent iron uptake system of the intestine.	Iron	82-86	transferrin	Homo sapiens	58-69
10559901-0	1999	Haem oxygenase-1 prevents cell death by regulating cellular iron.	Iron	60-64	heme oxygenase 1	Mus musculus	0-16
10559901-3	1999	Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts.	Iron	0-4	heme oxygenase 1	Mus musculus	39-42
10559901-5	1999	Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.	Iron	67-71	heme oxygenase 1	Mus musculus	24-27
10559901-5	1999	Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.	Iron	134-138	heme oxygenase 1	Mus musculus	24-27
10559901-5	1999	Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.	Iron	134-138	heme oxygenase 1	Mus musculus	102-105
10417735-11	1999	Together, these results suggest that Nramp1 may control intracellular microbial replication by actively removing iron or other divalent cations from the phagosomal space.	Iron	113-117	solute carrier family 11 member 1	Homo sapiens	37-43
10361139-10	1999	These results strongly suggest that Nramp2 is indeed responsible for transferrin-independent iron uptake in the duodenum.	Iron	93-97	transferrin	Homo sapiens	69-80
10442046-8	1999	It is speculated that high serum IgA levels might be caused by the following evidences 1) that transforming growth factor (TGF) beta, a known cytokine to increase IgA production by human splenic B cells, gene expression is enhanced in mononuclear cells from synovial fluid and 2) that iron deposition is found in RA synovial and high serum IgA levels are found in iron overload like thalassemia intermedia.	Iron	285-289	CD79a molecule	Homo sapiens	33-36
10442046-8	1999	It is speculated that high serum IgA levels might be caused by the following evidences 1) that transforming growth factor (TGF) beta, a known cytokine to increase IgA production by human splenic B cells, gene expression is enhanced in mononuclear cells from synovial fluid and 2) that iron deposition is found in RA synovial and high serum IgA levels are found in iron overload like thalassemia intermedia.	Iron	285-289	transforming growth factor beta 1	Homo sapiens	95-132
10442046-8	1999	It is speculated that high serum IgA levels might be caused by the following evidences 1) that transforming growth factor (TGF) beta, a known cytokine to increase IgA production by human splenic B cells, gene expression is enhanced in mononuclear cells from synovial fluid and 2) that iron deposition is found in RA synovial and high serum IgA levels are found in iron overload like thalassemia intermedia.	Iron	364-368	CD79a molecule	Homo sapiens	33-36
10442046-8	1999	It is speculated that high serum IgA levels might be caused by the following evidences 1) that transforming growth factor (TGF) beta, a known cytokine to increase IgA production by human splenic B cells, gene expression is enhanced in mononuclear cells from synovial fluid and 2) that iron deposition is found in RA synovial and high serum IgA levels are found in iron overload like thalassemia intermedia.	Iron	364-368	transforming growth factor beta 1	Homo sapiens	95-132
10369785-2	1999	HFE binds tightly to transferrin receptor (TfR), the receptor that mediates uptake of iron-loaded transferrin.	Iron	86-90	transferrin	Homo sapiens	21-32
10373350-1	1999	Iron is an essential nutrient for all organisms and consequently, the ability to bind transferrin and sequester iron from his source constitutes a distinct advantage to a blood-borne bacterial pathogen.	Iron	0-4	transferrin	Homo sapiens	86-97
10373350-2	1999	Levels of free iron are strictly limited in human serum, largely through the action of the iron-binding protein transferrin.	Iron	15-19	transferrin	Homo sapiens	112-123
10373350-2	1999	Levels of free iron are strictly limited in human serum, largely through the action of the iron-binding protein transferrin.	Iron	91-95	transferrin	Homo sapiens	112-123
10373350-5	1999	These proteins are independently and simultaneously capable of binding human transferrin and both are required for the optimal uptake of iron from this source.	Iron	137-141	transferrin	Homo sapiens	77-88
10373350-7	1999	This more exposed protein is capable of selectively binding iron-saturated transferrin and the receptor complex has ligand-binding properties which are distinct from either of its components.	Iron	60-64	transferrin	Homo sapiens	75-86
10373350-8	1999	Previous in vivo analyses of N. gonorrhoeae, which utilizes a closely related transferrin-iron uptake system, indicated that this receptor exists in several conformations influenced in part by the presence (or absence) of transferrin.	Iron	90-94	transferrin	Homo sapiens	78-89
10373350-8	1999	Previous in vivo analyses of N. gonorrhoeae, which utilizes a closely related transferrin-iron uptake system, indicated that this receptor exists in several conformations influenced in part by the presence (or absence) of transferrin.	Iron	90-94	transferrin	Homo sapiens	222-233
10373350-10	1999	We suggest that TbpB serves as the initial binding site for iron-saturated transferrin and brings this ligand close to the associated transmembrane dimer, enabling additional binding events and orientating transferrin over the dual TbpA pores.	Iron	60-64	transferrin	Homo sapiens	75-86
10373350-11	1999	The antagonistic association of these receptor proteins with a single ligand molecule may also induce conformational change in transferrin, thereby favouring the release of iron.	Iron	173-177	transferrin	Homo sapiens	127-138
10373350-12	1999	As, in vivo, transferrin may have iron in one or both lobes, this dynamic molecular arrangement would enable iron uptake from either iron-binding site.	Iron	34-38	transferrin	Homo sapiens	13-24
10373350-12	1999	As, in vivo, transferrin may have iron in one or both lobes, this dynamic molecular arrangement would enable iron uptake from either iron-binding site.	Iron	109-113	transferrin	Homo sapiens	13-24
10373350-12	1999	As, in vivo, transferrin may have iron in one or both lobes, this dynamic molecular arrangement would enable iron uptake from either iron-binding site.	Iron	109-113	transferrin	Homo sapiens	13-24
10422631-1	1999	Assessment of the efficacy of iron therapy has usually been done in populations/patients by monitoring changes in hemoglobin concentration, serum iron, percent transferrin saturation, and serum ferritin.	Iron	30-34	transferrin	Homo sapiens	160-171
10422630-6	1999	We have investigated the effect of modulating intracellular iron content on Epo production in Hep 3B cells.	Iron	60-64	erythropoietin	Homo sapiens	76-79
10364568-1	1999	Heart failure is the leading cause of mortality in patients with transfusional iron (Fe) overload in which myocardial iron uptake ensues via a transferrin-independent process.	Iron	79-83	transferrin	Homo sapiens	143-154
10364568-1	1999	Heart failure is the leading cause of mortality in patients with transfusional iron (Fe) overload in which myocardial iron uptake ensues via a transferrin-independent process.	Iron	85-87	transferrin	Homo sapiens	143-154
10364568-1	1999	Heart failure is the leading cause of mortality in patients with transfusional iron (Fe) overload in which myocardial iron uptake ensues via a transferrin-independent process.	Iron	118-122	transferrin	Homo sapiens	143-154
10422630-7	1999	Iron chelation stimulates Epo production at 20% O2 and enhances Epo production at 1% O2, but it has no additive effect on cobalt-induced Epo production.	Iron	0-4	erythropoietin	Homo sapiens	26-29
10422630-7	1999	Iron chelation stimulates Epo production at 20% O2 and enhances Epo production at 1% O2, but it has no additive effect on cobalt-induced Epo production.	Iron	0-4	erythropoietin	Homo sapiens	64-67
10422630-7	1999	Iron chelation stimulates Epo production at 20% O2 and enhances Epo production at 1% O2, but it has no additive effect on cobalt-induced Epo production.	Iron	0-4	erythropoietin	Homo sapiens	64-67
10422630-8	1999	Excess molar iron inhibited Epo production in response to hypoxia, desferrioxamine (DFO) and cobalt chloride and inhibited the DFO-enhancing effect of hypoxia-induced Epo production.	Iron	13-17	erythropoietin	Homo sapiens	28-31
10422630-8	1999	Excess molar iron inhibited Epo production in response to hypoxia, desferrioxamine (DFO) and cobalt chloride and inhibited the DFO-enhancing effect of hypoxia-induced Epo production.	Iron	13-17	erythropoietin	Homo sapiens	167-170
10336882-9	1999	Proposed functions for the oxidoreductase include stimulation of cell growth, reduction of the ascorbate free radical outside cells, recycling of alpha-tocopherol, reduction of lipid hydroperoxides, and reduction of ferric iron prior to iron uptake by a transferrin-independent pathway.	Iron	223-227	transferrin	Homo sapiens	254-265
10394459-0	1999	[Iron supplementation in preterm infants treated with erythropoietin].	Iron	1-5	erythropoietin	Homo sapiens	54-68
10333489-1	1999	Ethanol-inducible cytochrome P450 2E1 (CYP2E1) involved in the metabolism of gluconeogenetic precursors and some cytotoxins is distinguished from other cytochrome P450 enzymes by its rapid turnover (in vivo half-life of 4-7 h), with ligands to the haem iron, both substrates and inhibitors, stabilizing the protein.	Iron	253-257	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	18-37
10333489-1	1999	Ethanol-inducible cytochrome P450 2E1 (CYP2E1) involved in the metabolism of gluconeogenetic precursors and some cytotoxins is distinguished from other cytochrome P450 enzymes by its rapid turnover (in vivo half-life of 4-7 h), with ligands to the haem iron, both substrates and inhibitors, stabilizing the protein.	Iron	253-257	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	39-45
10568044-2	1999	In the submitted work we investigated the incidence of sideropenic anaemia in women during the first three months after a spontaneous delivery, changes of clinical and laboratory indicators of anaemia during this period and the possible effect exerted by administration of iron and iron plus folic acid resp. Ninety pregnant women in the 35th to 39th week of pregnancy were at random divided into three equally sized groups and the following were assessed: haemogram, indicators of iron reserves, serum concentrations of folic acid, vitamin B12, erythropoetin and soluble transferrin receptor, liver tests, total protein + electrophoresis, acute stage proteins.	Iron	273-277	transferrin	Homo sapiens	572-583
10568044-2	1999	In the submitted work we investigated the incidence of sideropenic anaemia in women during the first three months after a spontaneous delivery, changes of clinical and laboratory indicators of anaemia during this period and the possible effect exerted by administration of iron and iron plus folic acid resp. Ninety pregnant women in the 35th to 39th week of pregnancy were at random divided into three equally sized groups and the following were assessed: haemogram, indicators of iron reserves, serum concentrations of folic acid, vitamin B12, erythropoetin and soluble transferrin receptor, liver tests, total protein + electrophoresis, acute stage proteins.	Iron	282-286	transferrin	Homo sapiens	572-583
10568044-2	1999	In the submitted work we investigated the incidence of sideropenic anaemia in women during the first three months after a spontaneous delivery, changes of clinical and laboratory indicators of anaemia during this period and the possible effect exerted by administration of iron and iron plus folic acid resp. Ninety pregnant women in the 35th to 39th week of pregnancy were at random divided into three equally sized groups and the following were assessed: haemogram, indicators of iron reserves, serum concentrations of folic acid, vitamin B12, erythropoetin and soluble transferrin receptor, liver tests, total protein + electrophoresis, acute stage proteins.	Iron	282-286	transferrin	Homo sapiens	572-583
10230771-11	1999	Therefore, extracellular ascorbate derived from cells can enhance transferrin-independent iron uptake by reducing ferric to ferrous iron, but intracellular ascorbate neither contributes to this reduction nor modifies the redox status of intracellular free iron.	Iron	90-94	transferrin	Homo sapiens	66-77
10376783-0	1999	Zinc and IGF-I concentrations in pregnant women with anemia before and after supplementation with iron and/or zinc.	Iron	98-102	insulin like growth factor 1	Homo sapiens	9-14
10347134-5	1999	Iron loading was confirmed by increases in serum iron levels, percentages of transferrin saturation, ferritin levels, elevations in hepatic iron concentration (HIC), and by histological examination.	Iron	0-4	transferrin	Homo sapiens	77-88
10400457-9	1999	A significant positive correlation was found between vitamin E and non-transferrin-bound iron (NTBI) (r = -0.81; p &lt; 0.001), while no correlation was found between antioxidant depletion and ferritin serum levels, average blood consumption, or the presence of clinical complications.	Iron	89-93	transferrin	Homo sapiens	71-82
15819071-0	1999	[Study on the relationship between the concentration of iron manganese and turbid degree in river by AAS].	Iron	56-60	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	101-104
10356310-4	1999	We have investigated the production of Epo in response to three stimuli, hypoxia, cobalt chloride, and the iron chelator desferrioxamine, in Hep3B cells.	Iron	107-111	erythropoietin	Homo sapiens	39-42
10434423-1	1999	Transferrin is an iron-binding protein that plays an important role in iron metabolism and resistance to bacterial infection in a variety of organisms.	Iron	18-22	transferrin	Homo sapiens	0-11
10434423-1	1999	Transferrin is an iron-binding protein that plays an important role in iron metabolism and resistance to bacterial infection in a variety of organisms.	Iron	71-75	transferrin	Homo sapiens	0-11
10434423-3	1999	We hypothesize that the selective agent driving rapid divergence is interactions between host transferrin and the iron-scavenging proteins of pathogenic bacteria.	Iron	114-118	transferrin	Homo sapiens	94-105
11543141-2	1999	In the very largest particle events, IMP-8/CRT has even observed solar Fe ions above the Galactic cosmic ray background up to approximately 800 MeV/nucleon, an energy sufficiently high to penetrate nearly 25 g/cm2 of shielding.	Iron	71-73	importin 8	Homo sapiens	37-42
10329690-1	1999	Molecular modeling based on the crystal structure of the complex of bovine pancreatic RNase A with the inhibitor 5"-diphosphoadenosine 3"-phosphate (ppAp) (Leonidas, D. D., Shapiro, R., Irons, L. I., Russo, N., and Acharya, K. R. (1997) Biochemistry 36, 5578-5588) was used to design new inhibitors that extend into unoccupied regions of the enzyme active site.	Iron	186-191	ribonuclease pancreatic	Bos taurus	86-93
10353251-8	1999	In cells exposed to iron chelation or cobaltous ions, HIF-1 is dissociated from pVHL.	Iron	20-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-59
10353251-9	1999	These findings indicate that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF alpha-subunits.	Iron	71-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-58
10354297-1	1999	BACKGROUND: Inadequate iron mobilization and defective iron utilization may cause recombinant erythropoietin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	23-27	erythropoietin	Homo sapiens	94-108
10354297-1	1999	BACKGROUND: Inadequate iron mobilization and defective iron utilization may cause recombinant erythropoietin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	55-59	erythropoietin	Homo sapiens	94-108
10354297-1	1999	BACKGROUND: Inadequate iron mobilization and defective iron utilization may cause recombinant erythropoietin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	55-59	erythropoietin	Homo sapiens	94-108
10518388-19	1999	The last transfusion was in May 1997, due to hemoglobin values lower than 80 g l. In August 1997, the patient acquired recombinant erythropoietin and was hospitalized and treated in our institution by subcutaneous application of erythropoietin (50 mu kg) every other day, with monitoring of hemoglobin, hematocrit, erythrocyte count increase and values of serum iron.	Iron	362-366	erythropoietin	Homo sapiens	229-243
10356310-7	1999	In contrast, chelation of iron under hypoxic conditions markedly enhanced Epo production, suggesting that the two stimuli act by separate pathways.	Iron	26-30	erythropoietin	Homo sapiens	74-77
10229861-3	1999	By means of this and subsequent DNase I footprinting analysis we identified a regulatory region between -153 and -142 bp upstream of the transcriptional start site of the iNOS promoter that was sensitive to regulation by iron perturbation.	Iron	221-225	nitric oxide synthase 2, inducible	Mus musculus	171-175
10233880-0	1999	The effect of recombinant human erythropoietin on platelet counts is strongly modulated by the adequacy of iron supply.	Iron	107-111	erythropoietin	Homo sapiens	32-46
10229861-5	1999	Binding of NF-IL6 to its consensus motif within the iNOS promoter was inducible by IFN-gamma and/or LPS, was reduced by iron, and was enhanced by the iron chelator desferrioxamine.	Iron	120-124	nitric oxide synthase 2, inducible	Mus musculus	52-56
10229861-0	1999	Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression.	Iron	61-65	nitric oxide synthase 2, inducible	Mus musculus	96-127
10229861-1	1999	We have previously shown that iron regulates the transcription of inducible nitric oxide synthase (iNOS).	Iron	30-34	nitric oxide synthase 2, inducible	Mus musculus	66-97
10229861-5	1999	Binding of NF-IL6 to its consensus motif within the iNOS promoter was inducible by IFN-gamma and/or LPS, was reduced by iron, and was enhanced by the iron chelator desferrioxamine.	Iron	150-154	nitric oxide synthase 2, inducible	Mus musculus	52-56
10229861-1	1999	We have previously shown that iron regulates the transcription of inducible nitric oxide synthase (iNOS).	Iron	30-34	nitric oxide synthase 2, inducible	Mus musculus	99-103
10229861-6	1999	Introduction of a double mutation into the NF-IL6 binding site (-153/-142) of an iNOS promoter construct resulted in a reduction of IFN-gamma/LPS inducibility by &gt;90% and also impaired iron mediated regulation of the iNOS promoter.	Iron	188-192	nitric oxide synthase 2, inducible	Mus musculus	81-85
10229861-7	1999	Our results provide evidence that this NF-IL6 binding site is of central importance for maintaining a high transcriptional rate of the iNOS gene after IFN-gamma/LPS stimulation, and that NF-IL6 may cooperate with hypoxia inducible factor-1 in the orchestration of iron-mediated regulation of iNOS.	Iron	264-268	nitric oxide synthase 2, inducible	Mus musculus	135-139
10229861-7	1999	Our results provide evidence that this NF-IL6 binding site is of central importance for maintaining a high transcriptional rate of the iNOS gene after IFN-gamma/LPS stimulation, and that NF-IL6 may cooperate with hypoxia inducible factor-1 in the orchestration of iron-mediated regulation of iNOS.	Iron	264-268	interferon gamma	Mus musculus	151-160
10229861-7	1999	Our results provide evidence that this NF-IL6 binding site is of central importance for maintaining a high transcriptional rate of the iNOS gene after IFN-gamma/LPS stimulation, and that NF-IL6 may cooperate with hypoxia inducible factor-1 in the orchestration of iron-mediated regulation of iNOS.	Iron	264-268	nitric oxide synthase 2, inducible	Mus musculus	292-296
10318901-5	1999	Moreover, we show that HFE binding reduces the number of functional transferrin binding sites and impairs TfR internalization, thus reducing the uptake of transferrin-bound iron.	Iron	173-177	transferrin	Homo sapiens	155-166
10377948-2	1999	We now examine the effect of chelators, desferal (DFO, iron-specific) and neocupreine (NEO, copper-specific) on DNA of LY-R and LY-S cells, using the comet and micronuclei frequency tests.	Iron	55-59	lymphoma resistance	Mus musculus	119-123
10377948-3	1999	There is less copper and more iron in LY-R nuclei than in LY-S nuclei.	Iron	30-34	lymphoma resistance	Mus musculus	38-42
10217256-2	1999	In the present study, we demonstrate that dopamine promotes the selective sequestration of non-transferrin-derived iron by the mitochondrial compartment of cultured rat astroglia and that the mechanism underlying this novel dopamine effect is oxidative in nature.	Iron	115-119	transferrin	Rattus norvegicus	95-106
10215890-0	1999	Iron dependence of tryptophan hydroxylase activity in RBL2H3 cells and its manipulation by chelators.	Iron	0-4	RB transcriptional corepressor like 2	Rattus norvegicus	54-58
10217256-4	1999	Finally, we show that opening of the mitochondrial transition pore (MTP) mediates the influx of non-transferrin-derived iron into mitochondria of dopamine-stimulated and HO-1-transfected astroglia.	Iron	120-124	transferrin	Homo sapiens	100-111
10329956-0	1999	Transferrin stimulates iron absorption, exocytosis, and secretion in cultured intestinal cells.	Iron	23-27	transferrin	Homo sapiens	0-11
10329956-1	1999	The cellular mechanism by which basolateral transferrin (Tf) produces an increase in apical-to-basolateral Fe flux in Caco-2 cells was analyzed.	Iron	107-109	transferrin	Homo sapiens	44-55
10329956-1	1999	The cellular mechanism by which basolateral transferrin (Tf) produces an increase in apical-to-basolateral Fe flux in Caco-2 cells was analyzed.	Iron	107-109	transferrin	Homo sapiens	57-59
10329956-4	1999	Both apotransferrin and Fe-containing Tf produced similar increases in 59Fe efflux, Tf exocytosis, and apolipoprotein A secretion.	Iron	24-26	transferrin	Homo sapiens	38-40
10329956-4	1999	Both apotransferrin and Fe-containing Tf produced similar increases in 59Fe efflux, Tf exocytosis, and apolipoprotein A secretion.	Iron	24-26	transferrin	Homo sapiens	84-86
10329956-5	1999	The Ca2+ channel inhibitor SKF-96365 inhibited both the Tf-mediated increase in transepithelial Fe transport and the secretion of apolipoprotein A.	Iron	96-98	transferrin	Homo sapiens	56-58
10329956-6	1999	Thus the activation of transepithelial Fe transport by Tf seems to be mediated by Ca2+ entry into the cells.	Iron	39-41	transferrin	Homo sapiens	55-57
10226731-3	1999	Concomitant use of intravenous iron potently enhances the response to erythropoietin, and more recently other adjuvant therapies such as ascorbic acid, L-carnitine, folic acid, vitamin D, androgens, and other cytokines and growth factors have been investigated.	Iron	31-35	erythropoietin	Homo sapiens	70-84
10222387-9	1999	Only in girls, transferrin saturation as a measure for short-term iron status was inversely associated with calcium intake (adjusted overall coefficient -0.18 +/- 0.08).	Iron	66-70	transferrin	Homo sapiens	15-26
10426147-1	1999	Delivery of iron to the brain traditionally has been considered the responsibility of transferrin.	Iron	12-16	transferrin	Homo sapiens	86-97
10426147-2	1999	However, transferrin receptors in brain are located primarily within gray matter areas rather than in the iron rich white matter tracts.	Iron	106-110	transferrin	Homo sapiens	9-20
10231452-2	1999	Pyrophosphate strongly complexes iron and enhances iron transport between transferrin, ferritin, and tissues.	Iron	51-55	transferrin	Homo sapiens	74-85
10446756-5	1999	Active oxygen scavengers such as superoxide dismutase and catalase effectively blocked the formation of 8-OHdG in culture medium, and deferoxamine, which inhibits hydroxyl radicals production by chelating iron, was also effective in inhibiting the DEP-produced 8-OHdG formation.	Iron	205-209	catalase	Mus musculus	58-66
10341420-3	1999	They both encode for plasma membrane ferric/cupric reductases and their expression is regulated by iron and copper availability, mediated by the transcription factors Aft1p and Mac1p, respectively.	Iron	99-103	Mac1p	Saccharomyces cerevisiae S288C	177-182
10466194-6	1999	Recent studies indicate that the serum transferrin receptor is the preferred measurement, because enhanced synthesis of the transferrin receptor represent the initial cellular response to a declining Fe supply.	Iron	200-202	transferrin	Homo sapiens	39-50
10466194-6	1999	Recent studies indicate that the serum transferrin receptor is the preferred measurement, because enhanced synthesis of the transferrin receptor represent the initial cellular response to a declining Fe supply.	Iron	200-202	transferrin	Homo sapiens	124-135
10466194-8	1999	In an otherwise normal healthy population the transferrin receptor: ferritin value provides a useful quantitative index of body Fe over a wide spectrum of Fe status, ranging from Fe repletion to Fe-deficiency anaemia.	Iron	128-130	transferrin	Homo sapiens	46-57
10466194-8	1999	In an otherwise normal healthy population the transferrin receptor: ferritin value provides a useful quantitative index of body Fe over a wide spectrum of Fe status, ranging from Fe repletion to Fe-deficiency anaemia.	Iron	155-157	transferrin	Homo sapiens	46-57
10466194-8	1999	In an otherwise normal healthy population the transferrin receptor: ferritin value provides a useful quantitative index of body Fe over a wide spectrum of Fe status, ranging from Fe repletion to Fe-deficiency anaemia.	Iron	155-157	transferrin	Homo sapiens	46-57
10466194-9	1999	It is concluded that optimal Fe nutrition is best defined as a normal haemoglobin, serum ferritin and transferrin receptor concentration.	Iron	29-31	transferrin	Homo sapiens	102-113
10194366-1	1999	The active site of tyrosine hydroxylase consists of a hydrophobic cleft with an iron atom near the bottom.	Iron	80-84	tyrosine hydroxylase	Homo sapiens	19-39
10231572-0	1999	Duplicate genes for Fe-containing superoxide dismutase in Streptomyces coelicolor A3(2).	Iron	20-22	SCO2633	Streptomyces coelicolor A3(2)	34-54
10231572-2	1999	Unlike a single species of Fe-containing SOD in Muller strain, multiple forms of FeSODs were detected in S. coelicolor A3(2) strain by activity staining and Western blot analysis.	Iron	27-29	SCO2633	Streptomyces coelicolor A3(2)	41-44
10226041-1	1999	The understanding of iron metabolism at the molecular level has been enormously expanded in recent years by new findings about the functioning of transferrin, the transferrin receptor and ferritin.	Iron	21-25	transferrin	Homo sapiens	146-157
10092536-5	1999	Beside the presence of redox-active iron several iron-binding proteins like transferrin, ferritin and lactoferrin were determined in BAS.	Iron	49-53	transferrin	Homo sapiens	76-87
10085238-1	1999	Neisseria meningitidis, grown in iron-limited conditions, produces two transferrin-binding proteins (TbpA and TbpB) that independently and specifically bind human serum transferrin (hTF) but not bovine serum transferrin (bTF).	Iron	33-37	transferrin	Homo sapiens	71-82
10342073-2	1999	Initial iron studies showed raised serum iron and transferrin saturation but low ferritin and were interpreted as consistent with iron deficiency under treatment.	Iron	8-12	transferrin	Homo sapiens	50-61
10234700-0	1999	Role of iron in optimizing responses of anemic cancer patients to erythropoietin.	Iron	8-12	erythropoietin	Homo sapiens	66-80
10333344-9	1999	These results showed that insulin resistance might participate in the genesis of sodium sensitivity in essential hypertension by enhancing tubular sodium reabsorption, as reflected in decreased FE(Na) and augmented creatinine clearance.	Iron	194-196	insulin	Homo sapiens	26-33
10207812-1	1999	BACKGROUND/AIMS: The aim of this study was to investigate if feeding with carbonyl iron would facilitate the development of preneoplastic lesions initiated by diethylnitrosamine (DEN) and promoted by CCl4-induced liver cirrhosis.	Iron	83-87	C-C motif chemokine ligand 4	Rattus norvegicus	200-204
10207812-5	1999	RESULTS: Treatment with iron counteracted the increased serum alanine aminotransferase levels and liver necrosis following CCl4 administration.	Iron	24-28	C-C motif chemokine ligand 4	Rattus norvegicus	123-127
10207812-8	1999	Nine weeks after DEN initiation, the number and volume density of GST-7,7-positive foci in rats treated with CCl4 were significantly increased as compared with controls, but co-treatment with iron inhibited this increase.	Iron	192-196	glutathione S-transferase pi 1	Rattus norvegicus	66-73
10207812-8	1999	Nine weeks after DEN initiation, the number and volume density of GST-7,7-positive foci in rats treated with CCl4 were significantly increased as compared with controls, but co-treatment with iron inhibited this increase.	Iron	192-196	C-C motif chemokine ligand 4	Rattus norvegicus	109-113
10207812-9	1999	Apoptotic index was increased in iron-loaded livers, and labelling index (the fraction of S-phase hepatocytes) was decreased by co-treatment with iron in livers exposed to CCl4.	Iron	146-150	C-C motif chemokine ligand 4	Rattus norvegicus	172-176
10207812-10	1999	CONCLUSION: Carbonyl iron depleted hepatic levels of antioxidants, it decreased CCl4-induced necrosis and cell proliferation, it enhanced apoptosis and did not facilitate fibrogenesis.	Iron	21-25	C-C motif chemokine ligand 4	Rattus norvegicus	80-84
10207812-11	1999	These effects together may explain the suppression of CCl4-induced promotion after DEN initiation exerted by carbonyl iron in the present study.	Iron	118-122	C-C motif chemokine ligand 4	Rattus norvegicus	54-58
10385880-9	1999	After absorption into the blood system by these alternate routes, Mn is apparently oxidized by ceruloplasmin and the trivalent Mn binds to the iron carrying protein, transferrin.	Iron	143-147	transferrin	Homo sapiens	166-177
10074011-0	1999	Iron supplemented formula milk related to reduction in psychomotor decline in infants from inner city areas: randomised study.	Iron	0-4	Weaning weight-maternal milk	Bos taurus	26-30
10355137-0	1999	[Decrease serum erythropoietin level induced by iron replacement therapy in patients with iron deficiency anemia].	Iron	48-52	erythropoietin	Homo sapiens	16-30
10355137-1	1999	The relationship between serum erythropoietin (EP) and hemoglobin (Hb) concentrations was investigated in patients of iron deficiency anemia (IDA) in the course of iron replacement therapy to elucidate how the therapy induced changes in that relationship.	Iron	118-122	erythropoietin	Homo sapiens	31-45
10355137-1	1999	The relationship between serum erythropoietin (EP) and hemoglobin (Hb) concentrations was investigated in patients of iron deficiency anemia (IDA) in the course of iron replacement therapy to elucidate how the therapy induced changes in that relationship.	Iron	118-122	erythropoietin	Homo sapiens	47-49
10355137-3	1999	Following the start of iron supply, the deviation of observed EP values from the predicted level (EPc), i.e., delta-EP, was most obvious at the next phase of the onset of reticulocyte crisis; however, this deviation reduced with the alleviation of IDA.	Iron	23-27	erythropoietin	Homo sapiens	62-64
10355137-3	1999	Following the start of iron supply, the deviation of observed EP values from the predicted level (EPc), i.e., delta-EP, was most obvious at the next phase of the onset of reticulocyte crisis; however, this deviation reduced with the alleviation of IDA.	Iron	23-27	erythropoietin	Homo sapiens	98-100
10367478-0	1999	Is serum transferrin receptor a sensitive marker of iron repletion in patients with iron-deficiency anemia and hemodialysis patients?	Iron	52-56	transferrin	Homo sapiens	9-20
10367478-6	1999	The three patients with iron-deficiency anemia who received eight to 16 weeks of iron supplementation showed steady and significant decreases in sTfR concentration and significant increases in serum ferritin and transferrin saturation.	Iron	24-28	transferrin	Homo sapiens	212-223
10085150-0	1999	The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.	Iron	89-93	transferrin	Homo sapiens	68-79
10085150-15	1999	Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments.	Iron	57-61	transferrin	Homo sapiens	67-69
10085150-16	1999	HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered.	Iron	25-29	transferrin	Homo sapiens	42-44
10085150-16	1999	HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered.	Iron	65-69	transferrin	Homo sapiens	53-55
10085150-17	1999	These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake.	Iron	157-161	transferrin	Homo sapiens	134-136
10385037-3	1999	Besides hypoxia, transition metals (Co2+, Ni2+ and Mn2+) and iron chelation also promote activation of HIF-1.	Iron	61-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-108
10066817-13	1999	Recruitment of these broadly active transcriptional adaptor proteins for ferritin H synthesis may represent an important mechanism by which changes in iron metabolism are coordinated with other cellular responses mediated by p300/CBP.	Iron	151-155	ferritin mitochondrial	Mus musculus	73-83
10218886-4	1999	It is suggested that the upregulation of transferrin receptor expression coupled with iron uptake by amoeboid microglial cells in the periventricular regions is a protective mechanism to facilitate the sequestration of excess iron that may have been released either from the iron-rich oligodendrocytes, or accumulated due to a disruption of its normal transportation following the hypoxic insult.	Iron	86-90	transferrin	Rattus norvegicus	41-52
10218886-4	1999	It is suggested that the upregulation of transferrin receptor expression coupled with iron uptake by amoeboid microglial cells in the periventricular regions is a protective mechanism to facilitate the sequestration of excess iron that may have been released either from the iron-rich oligodendrocytes, or accumulated due to a disruption of its normal transportation following the hypoxic insult.	Iron	226-230	transferrin	Rattus norvegicus	41-52
10218886-4	1999	It is suggested that the upregulation of transferrin receptor expression coupled with iron uptake by amoeboid microglial cells in the periventricular regions is a protective mechanism to facilitate the sequestration of excess iron that may have been released either from the iron-rich oligodendrocytes, or accumulated due to a disruption of its normal transportation following the hypoxic insult.	Iron	226-230	transferrin	Rattus norvegicus	41-52
10074011-5	1999	INTERVENTION: Changing to an iron supplemented formula milk from enrolment to 18 months of age, or continuing with unmodified cows" milk.	Iron	29-33	Weaning weight-maternal milk	Bos taurus	55-59
10069791-0	1999	Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice.	Iron	0-4	apolipoprotein E	Mus musculus	55-59
10069791-4	1999	METHODS AND RESULTS: Iron deposition in tissues of apoE-deficient mice was examined by Perls" staining method.	Iron	21-25	apolipoprotein E	Mus musculus	51-55
10074011-12	1999	CONCLUSION: Replacing unmodified cows" milk with an iron supplemented formula milk up to 18 months of age in infants from inner city areas prevents iron deficiency anaemia and reduces the decline in psychomotor development seen in such infants from the second half of the first year.	Iron	52-56	Weaning weight-maternal milk	Bos taurus	78-82
10069791-12	1999	CONCLUSIONS: Iron deposition is closely associated with the progression of atherosclerosis in apoE-deficient mice.	Iron	13-17	apolipoprotein E	Mus musculus	94-98
15374090-11	1999	After iron supplementation, the average hemoglobin level increased from 9.0 to 10.5 g/dl, and the average hANP level was reduced from 58.3+/-23.5 to 41.2+/-27.9 pg/ml, which was statistically significant by Wilcoxon"s signed rank sum test.	Iron	6-10	natriuretic peptide A	Homo sapiens	106-110
10082971-2	1999	Transferrin-dependent iron uptake is defective because of a mutation in Nramp2 (now DMT1, also called DCT1), the protein responsible for endosomal iron efflux.	Iron	22-26	transferrin	Rattus norvegicus	0-11
10082971-2	1999	Transferrin-dependent iron uptake is defective because of a mutation in Nramp2 (now DMT1, also called DCT1), the protein responsible for endosomal iron efflux.	Iron	22-26	solute carrier family 11 member 2	Rattus norvegicus	72-78
10082971-2	1999	Transferrin-dependent iron uptake is defective because of a mutation in Nramp2 (now DMT1, also called DCT1), the protein responsible for endosomal iron efflux.	Iron	22-26	solute carrier family 11 member 2	Rattus norvegicus	84-88
10082971-2	1999	Transferrin-dependent iron uptake is defective because of a mutation in Nramp2 (now DMT1, also called DCT1), the protein responsible for endosomal iron efflux.	Iron	147-151	transferrin	Rattus norvegicus	0-11
10082971-2	1999	Transferrin-dependent iron uptake is defective because of a mutation in Nramp2 (now DMT1, also called DCT1), the protein responsible for endosomal iron efflux.	Iron	147-151	solute carrier family 11 member 2	Rattus norvegicus	72-78
10082971-2	1999	Transferrin-dependent iron uptake is defective because of a mutation in Nramp2 (now DMT1, also called DCT1), the protein responsible for endosomal iron efflux.	Iron	147-151	solute carrier family 11 member 2	Rattus norvegicus	84-88
10070911-2	1999	iron compound, sodium ferric gluconate complex in sucrose (Ferrlecit, R&amp;D Laboratories, Inc, Marina Del Rey, CA), was administered over 8 consecutive dialysis days in equally divided doses to a total of either 0.5 or 1.0 g in a controlled, open, multicenter, randomized clinical study of anemic, iron-deficient hemodialysis patients receiving recombinant human erythropoietin (rHuEPO).	Iron	0-4	erythropoietin	Homo sapiens	365-379
10070911-15	1999	This study confirms the concepts regarding iron therapy expressed in the National Kidney Foundation Dialysis Outcomes Quality Initiative (NKF-DOQI) that hemodialysis patients with serum ferritin below 100 ng/mL or transferrin saturations below 18% need supplementation with parenteral iron in excess of 1.0 g to achieve optimal response in hemoglobin and hematocrit levels.	Iron	43-47	transferrin	Homo sapiens	214-225
10412499-3	1999	The iron deficiency diagnostic by saturation of transferrin &lt; 16% and zinc protoporphyrin concentration &gt; 60 (mol/mol heme were 45.8 and 42.6%, respectively.	Iron	4-8	transferrin	Homo sapiens	48-59
15374090-5	1999	Plasma concentrations of human atrial natriuretic peptide (hANP) after iron therapy were determined by immunoradiometric assay.	Iron	71-75	natriuretic peptide A	Homo sapiens	59-63
19649942-7	1999	The endogenous iron/transferrin transport system has been used extensively preclinically to deliver intravenously administered nerve growth factor (NGF) to the brain and serves as the major focus for this discussion.	Iron	15-19	transferrin	Homo sapiens	20-31
10103001-5	1999	We provide evidence that to mediate this reaction, the ferric form of horseradish peroxidase must be converted by O2.- into the perferryl form (Compound III), in which the haem iron can assume the ferrous state.	Iron	177-181	peroxidase	Glycine max	82-92
10051465-0	1999	Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol abuse, is highly influenced by body iron.	Iron	110-114	transferrin	Homo sapiens	23-34
10024586-6	1999	When we treated recombinant gamma interferon (IFN-gamma)-activated macrophages with iron, we found that iron abrogated the growth inhibitory effect of IFN-gamma-activated macrophages from Bcgs mice but that it did not affect the capacity of macrophages from Bcgr mice to control microbial growth.	Iron	84-88	interferon gamma	Mus musculus	28-55
10024586-6	1999	When we treated recombinant gamma interferon (IFN-gamma)-activated macrophages with iron, we found that iron abrogated the growth inhibitory effect of IFN-gamma-activated macrophages from Bcgs mice but that it did not affect the capacity of macrophages from Bcgr mice to control microbial growth.	Iron	84-88	interferon gamma	Mus musculus	46-55
10024586-6	1999	When we treated recombinant gamma interferon (IFN-gamma)-activated macrophages with iron, we found that iron abrogated the growth inhibitory effect of IFN-gamma-activated macrophages from Bcgs mice but that it did not affect the capacity of macrophages from Bcgr mice to control microbial growth.	Iron	104-108	interferon gamma	Mus musculus	28-55
10024586-6	1999	When we treated recombinant gamma interferon (IFN-gamma)-activated macrophages with iron, we found that iron abrogated the growth inhibitory effect of IFN-gamma-activated macrophages from Bcgs mice but that it did not affect the capacity of macrophages from Bcgr mice to control microbial growth.	Iron	104-108	interferon gamma	Mus musculus	46-55
10024586-8	1999	The effect of iron on the growth inhibitory activity of macrophages from Bcgr mice was abrogated by the addition of catalase or mannitol to the culture medium.	Iron	14-18	catalase	Mus musculus	116-124
10024528-14	1999	In addition, the well-characterized Fe3+-chelate reduction capabilities of NFR, in addition to known Fe3+-haemoglobin reduction roles for mammal b5R isoforms, suggest further and more generalized roles for the b5R class in endocellular iron reduction.	Iron	236-240	ferric-chelate reductase (NADH)1	Zea mays	75-78
10103001-9	1999	The .OH-producing activity of horseradish peroxidase can be inhibited by inactivators of haem iron or by various O2.- and .OH scavengers.	Iron	94-98	peroxidase	Glycine max	42-52
10103001-10	1999	On an equimolar Fe basis, horseradish peroxidase is 1-2 orders of magnitude more active than Fe-EDTA, an inorganic catalyst of the Haber-Weiss reaction.	Iron	16-18	peroxidase	Glycine max	38-48
10203183-7	1999	CONCLUSIONS: Transferrin is involved in the transport of iron into germ cells and in cell differentiation.	Iron	57-61	transferrin	Rattus norvegicus	13-24
9989781-0	1999	Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells.	Iron	22-26	transferrin	Rattus norvegicus	4-15
10218143-11	1999	The serum of patients with pathological iron overload can contain non-transferrin-bound iron inducing lipid peroxidation with subsequent consumption of antioxidants such as vitamin E and vitamin C.	Iron	40-44	transferrin	Homo sapiens	70-81
10218143-11	1999	The serum of patients with pathological iron overload can contain non-transferrin-bound iron inducing lipid peroxidation with subsequent consumption of antioxidants such as vitamin E and vitamin C.	Iron	88-92	transferrin	Homo sapiens	70-81
10999121-6	1999	Patients on EPO developed a significant decline in serum iron, serum ferritin levels, bone marrow iron stores; and a hypochromic-microcytic picture on the peripheral blood film suggestive of iron deficiency.	Iron	57-61	erythropoietin	Homo sapiens	12-15
10999121-6	1999	Patients on EPO developed a significant decline in serum iron, serum ferritin levels, bone marrow iron stores; and a hypochromic-microcytic picture on the peripheral blood film suggestive of iron deficiency.	Iron	98-102	erythropoietin	Homo sapiens	12-15
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	27-31	transferrin	Rattus norvegicus	0-11
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	27-31	transferrin	Rattus norvegicus	13-15
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	27-31	solute carrier family 11 member 2	Rattus norvegicus	77-81
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	27-31	solute carrier family 11 member 2	Rattus norvegicus	83-89
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	111-115	transferrin	Rattus norvegicus	0-11
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	111-115	transferrin	Rattus norvegicus	13-15
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	111-115	solute carrier family 11 member 2	Rattus norvegicus	77-81
9989781-2	1999	Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux.	Iron	111-115	solute carrier family 11 member 2	Rattus norvegicus	83-89
9989781-3	1999	This experiment of nature permits the present study to address whether the mutation also affects non-Tf-bound iron (NTBI) uptake and to use NTBI uptake compared to Tf-Fe utilization to increase understanding of the phenotype of the b mutation.	Iron	110-114	transferrin	Rattus norvegicus	101-103
9989781-3	1999	This experiment of nature permits the present study to address whether the mutation also affects non-Tf-bound iron (NTBI) uptake and to use NTBI uptake compared to Tf-Fe utilization to increase understanding of the phenotype of the b mutation.	Iron	167-169	transferrin	Rattus norvegicus	164-166
9989781-11	1999	DMT1 serves in both apparent high-affinity NTBI membrane transport and the exit of iron from the endosome during Tf delivery of iron in rat reticulocytes; the low-affinity membrane transporter, however, exhibits little dependence on DMT1.	Iron	83-87	solute carrier family 11 member 2	Rattus norvegicus	0-4
9989781-11	1999	DMT1 serves in both apparent high-affinity NTBI membrane transport and the exit of iron from the endosome during Tf delivery of iron in rat reticulocytes; the low-affinity membrane transporter, however, exhibits little dependence on DMT1.	Iron	128-132	solute carrier family 11 member 2	Rattus norvegicus	0-4
9989781-11	1999	DMT1 serves in both apparent high-affinity NTBI membrane transport and the exit of iron from the endosome during Tf delivery of iron in rat reticulocytes; the low-affinity membrane transporter, however, exhibits little dependence on DMT1.	Iron	128-132	transferrin	Rattus norvegicus	113-115
10197487-2	1999	The mechanisms involved are largely unknown; however, it is likely that the two major proteins of iron metabolism, ferritin and transferrin are intimately involved in the process.	Iron	98-102	transferrin	Homo sapiens	128-139
10049947-9	1999	These findings suggest that Nramp2 plays a key role in the metabolism of transferrin-bound iron by transporting free Fe2+ across the endosomal membrane and into the cytoplasm.	Iron	91-95	transferrin	Homo sapiens	73-84
10024547-1	1999	Staphylococcus aureus and Staphylococcus epidermidis possess a 42-kDa cell wall transferrin-binding protein (Tpn) which is involved in the acquisition of transferrin-bound iron.	Iron	172-176	transferrin	Homo sapiens	80-91
10024547-1	1999	Staphylococcus aureus and Staphylococcus epidermidis possess a 42-kDa cell wall transferrin-binding protein (Tpn) which is involved in the acquisition of transferrin-bound iron.	Iron	172-176	transferrin	Homo sapiens	154-165
10197487-6	1999	This review describes briefly the role of ferritin and transferrin in normal iron metabolism and in iron overload disease and explores the possible involvement of these proteins in the pathophysiology of excess iron deposition in alcoholic subjects.	Iron	77-81	transferrin	Homo sapiens	55-66
10024547-4	1999	Analysis of staphylococcal cell wall fractions for GAPDH activity confirmed the presence of a functional enzyme which, like Tpn, is regulated by the availability of iron in the growth medium.	Iron	165-169	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	51-56
10068709-4	1999	When treatment is required, erythropoietin is administered, often with iron supplementation.	Iron	71-75	erythropoietin	Homo sapiens	28-42
10084280-2	1999	Hence, specialized molecules for the acquisition, transport (transferrin), and storage (ferritin) of iron in a soluble nontoxic form have evolved.	Iron	101-105	transferrin	Homo sapiens	61-72
10084280-3	1999	Delivery of iron to most cells, probably including those of the kidney, occurs following the binding of transferrin to transferrin receptors on the cell membrane.	Iron	12-16	transferrin	Homo sapiens	104-115
10084280-3	1999	Delivery of iron to most cells, probably including those of the kidney, occurs following the binding of transferrin to transferrin receptors on the cell membrane.	Iron	12-16	transferrin	Homo sapiens	119-130
10084280-4	1999	The transferrin-receptor complexes are then internalized by endocytosis, and iron is released from transferrin by a process involving endosomal acidification.	Iron	77-81	transferrin	Homo sapiens	4-15
10084280-4	1999	The transferrin-receptor complexes are then internalized by endocytosis, and iron is released from transferrin by a process involving endosomal acidification.	Iron	77-81	transferrin	Homo sapiens	99-110
10084280-5	1999	Cellular iron storage and uptake are coordinately regulated post-transcriptionally by cytoplasmic factors, iron-regulatory proteins 1 and 2 (IRP-1 and IRP-2).	Iron	9-13	iron responsive element binding protein 2	Homo sapiens	151-156
10084280-6	1999	Under conditions of limited iron supply, IRP binding to iron-responsive elements (present in 5" untranslated region of ferritin mRNA and 3" untranslated region of transferrin receptor mRNA) blocks ferritin mRNA translation and stabilizes transferrin receptor mRNA.	Iron	56-60	transferrin	Homo sapiens	238-249
10084284-0	1999	Iron overload in renal failure patients: changes since the introduction of erythropoietin therapy.	Iron	0-4	erythropoietin	Homo sapiens	75-89
10084285-1	1999	The management of recombinant human erythropoietin (rHuEPO) treatment in hemodialysis patients requires close monitoring of iron status, because the pharmacologically stimulated erythropoiesis is particularly dependent on a continuous supply of iron.	Iron	124-128	erythropoietin	Homo sapiens	36-50
10084285-1	1999	The management of recombinant human erythropoietin (rHuEPO) treatment in hemodialysis patients requires close monitoring of iron status, because the pharmacologically stimulated erythropoiesis is particularly dependent on a continuous supply of iron.	Iron	245-249	erythropoietin	Homo sapiens	36-50
10084285-2	1999	Parameters commonly measured to assess iron status are serum ferritin and the transferrin saturation.	Iron	39-43	transferrin	Homo sapiens	78-89
10084288-1	1999	Iron supplementation has become an integral part of the management of patients receiving epoetin therapy, and clinicians have found it necessary to learn how and when to use it to the best advantage.	Iron	0-4	erythropoietin	Homo sapiens	89-96
10084288-8	1999	iron preparations can induce "free iron" reactions if the circulating plasma transferrin is overloaded.	Iron	0-4	transferrin	Homo sapiens	77-88
10084288-8	1999	iron preparations can induce "free iron" reactions if the circulating plasma transferrin is overloaded.	Iron	35-39	transferrin	Homo sapiens	77-88
10084288-9	1999	Intravenous iron may be given in advance of epoetin therapy, as concomitant treatment to prevent the development of iron deficiency, as treatment of absolute or functional iron deficiency, or as adjuvant therapy to enhance the response to epoetin in iron-replete patients.	Iron	12-16	erythropoietin	Homo sapiens	239-246
10084288-11	1999	iron include a serum ferritin of less than 100 microg/liter, a transferrin saturation of less than 20%, and a percentage of hypochromic red cells more than 10%.	Iron	0-4	transferrin	Homo sapiens	63-74
10084288-18	1999	iron almost certainly outweigh the risks in terms of optimizing the response to epoetin therapy.	Iron	0-4	erythropoietin	Homo sapiens	80-87
10084290-1	1999	Iron deficiency represents an important problem in peritoneal dialysis patients, especially during erythropoietin therapy.	Iron	0-4	erythropoietin	Homo sapiens	99-113
10084291-7	1999	iron is that if EPO is needed, lower doses will be required to achieve the target Hct than if EPO were used alone.	Iron	0-4	erythropoietin	Homo sapiens	16-19
10084291-7	1999	iron is that if EPO is needed, lower doses will be required to achieve the target Hct than if EPO were used alone.	Iron	0-4	erythropoietin	Homo sapiens	94-97
10084294-0	1999	Erythropoietin hyporesponsiveness: from iron deficiency to iron overload.	Iron	40-44	erythropoietin	Homo sapiens	0-14
10084296-1	1999	Intravenous iron therapy maintains iron stores and decreases erythropoietin demand in patients undergoing regular dialysis therapy.	Iron	12-16	erythropoietin	Homo sapiens	61-75
10037492-2	1999	HO-1 cleaves the heme molecule and produces carbon monoxide (CO) and biliverdin (an antioxidant) and is essential for iron homeostasis.	Iron	118-122	heme oxygenase 1	Mus musculus	0-4
10084297-4	1999	Administration of iron with erythropoietin to such patients requires careful and frequent evaluation of hematologic and iron values.	Iron	18-22	erythropoietin	Homo sapiens	28-42
10084297-4	1999	Administration of iron with erythropoietin to such patients requires careful and frequent evaluation of hematologic and iron values.	Iron	120-124	erythropoietin	Homo sapiens	28-42
10084298-1	1999	Intensive iron therapy is now a generally accepted adjunct for the treatment of renal anemia with recombinant human erythropoietin.	Iron	10-14	erythropoietin	Homo sapiens	116-130
10203757-2	1999	Bacteria use siderophores to chelate Fe3+ and iron in heme, hemoglobin, transferrin and lactoferrin, and employ novel mechanisms for receptor-dependent iron transport and iron-regulated gene expression.	Iron	46-50	transferrin	Homo sapiens	72-83
9990067-4	1999	In the present study, we examined the relationship of the HFE protein to the TfR in enterocytes of the human duodenum and measured the uptake of transferrin-bound iron and ionic iron by isolated crypt and villus enterocytes.	Iron	163-167	transferrin	Homo sapiens	145-156
9990067-7	1999	The crypt cell fraction exhibited dramatically higher transferrin-bound iron uptake than villus cells.	Iron	72-76	transferrin	Homo sapiens	54-65
9990067-9	1999	We propose that the HFE protein modulates the uptake of transferrin-bound iron from plasma by crypt enterocytes and participates in the mechanism by which the crypt enterocytes sense the level of body iron stores.	Iron	74-78	transferrin	Homo sapiens	56-67
9990067-9	1999	We propose that the HFE protein modulates the uptake of transferrin-bound iron from plasma by crypt enterocytes and participates in the mechanism by which the crypt enterocytes sense the level of body iron stores.	Iron	201-205	transferrin	Homo sapiens	56-67
10355873-0	1999	Transferrin synthesized in cultured human fibroblasts is associated with tubulins and has iron binding capacity.	Iron	90-94	transferrin	Homo sapiens	0-11
10355873-4	1999	In addition, the transferrin associated with tubulins was found to bind to iron.	Iron	75-79	transferrin	Homo sapiens	17-28
10355873-5	1999	These results suggest that endogenous transferrin plays a role in preventing damage caused by free radicals which can be induced by the interaction of iron with the hydrogen peroxide produced in cells.	Iron	151-155	transferrin	Homo sapiens	38-49
10371304-9	1999	These results indicate that iron deprivation by hinokitiol can induce apoptosis of F9 cells through the activation of caspase-3.	Iron	28-32	caspase 3	Homo sapiens	118-127
9989766-0	1999	Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease.	Iron	17-21	transferrin	Homo sapiens	44-55
9927288-5	1999	Under normoxic conditions, the iron chelator desferrioxamine and the antioxidant vitamin A increased renal Epo production, mimicking hypoxic induction.	Iron	31-35	erythropoietin	Homo sapiens	107-110
9916061-3	1999	Iron-saturated human transferrin and lactoferrin, but not ferric chloride and the iron-free form of transferrin, could be used as sources of iron by P. nigrescens and P. intermedia.	Iron	0-4	transferrin	Homo sapiens	21-32
9916061-3	1999	Iron-saturated human transferrin and lactoferrin, but not ferric chloride and the iron-free form of transferrin, could be used as sources of iron by P. nigrescens and P. intermedia.	Iron	141-145	transferrin	Homo sapiens	21-32
9916061-3	1999	Iron-saturated human transferrin and lactoferrin, but not ferric chloride and the iron-free form of transferrin, could be used as sources of iron by P. nigrescens and P. intermedia.	Iron	141-145	transferrin	Homo sapiens	100-111
9916061-12	1999	The transferrin-binding activity of P. nigrescens and P. intermedia may permit the bacteria to obtain iron for survival and growth in periodontal pockets.	Iron	102-106	transferrin	Homo sapiens	4-15
9989766-7	1999	In contrast, at Tf-Fe concentrations of 0.25 to 2.5 micromol/L, 59Fe uptake in FAC-treated cells was only 1-fold to 3-fold greater than that in the corresponding controls.	Iron	19-21	FA complementation group C	Homo sapiens	79-82
9989766-8	1999	These data suggest that the FAC-activated Fe uptake process predominates at physiologically relevant Tf concentrations above the saturation of the Tf receptor (TfR).	Iron	42-44	FA complementation group C	Homo sapiens	28-31
10048613-0	1999	Oral iron is sufficient for erythropoietin treatment of very low birth-weight infants.	Iron	5-9	erythropoietin	Homo sapiens	28-42
10048613-1	1999	UNLABELLED: The aim of this study was to compare two different doses and means of administration of iron in recombinant human erythropoietin (rHuEPO)-treated very low birth-weight (VLBW) infants.	Iron	100-104	erythropoietin	Homo sapiens	126-140
10048613-8	1999	CONCLUSION: In erythropoietin-treated very low birth weight infants the iron need for erythropoiesis can be met by oral administration of iron.	Iron	72-76	erythropoietin	Homo sapiens	15-29
10048613-8	1999	CONCLUSION: In erythropoietin-treated very low birth weight infants the iron need for erythropoiesis can be met by oral administration of iron.	Iron	138-142	erythropoietin	Homo sapiens	15-29
9918923-1	1999	Nitric oxide (NO) donors S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside (SNP) modulate iron regulatory protein (IRP) activity and may, therefore, affect iron uptake through transferrin receptor expression.	Iron	104-108	transferrin	Homo sapiens	190-201
10029288-0	1999	Non-transferrin-bound iron and cellular toxicity.	Iron	22-26	transferrin	Homo sapiens	4-15
10029292-0	1999	Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload.	Iron	22-26	transferrin	Homo sapiens	4-15
10029292-1	1999	BACKGROUND: Circulating iron is normally bound to transferrin.	Iron	24-28	transferrin	Homo sapiens	50-61
10029292-2	1999	Non-transferrin-bound iron (NTBI) has been described in most forms of iron overload, but has not been studied in African dietary iron overload.	Iron	22-26	transferrin	Homo sapiens	4-15
10029292-2	1999	Non-transferrin-bound iron (NTBI) has been described in most forms of iron overload, but has not been studied in African dietary iron overload.	Iron	70-74	transferrin	Homo sapiens	4-15
10029292-2	1999	Non-transferrin-bound iron (NTBI) has been described in most forms of iron overload, but has not been studied in African dietary iron overload.	Iron	70-74	transferrin	Homo sapiens	4-15
10029292-6	1999	RESULTS: Non-transferrin-bound iron (&gt; 2 micromol/L) was present in 43 people, 22 of patients of whom underwent liver biopsy and 21 relatives and neighbours.	Iron	31-35	transferrin	Homo sapiens	13-24
10029292-10	1999	Non-transferrin-bound iron correlated significantly with elevations in alanine and aspartate aminotransferase activities after adjustment for hepatic iron grades, inflammation and diet.	Iron	22-26	transferrin	Homo sapiens	4-15
10029292-10	1999	Non-transferrin-bound iron correlated significantly with elevations in alanine and aspartate aminotransferase activities after adjustment for hepatic iron grades, inflammation and diet.	Iron	150-154	transferrin	Homo sapiens	4-15
10029292-11	1999	CONCLUSIONS: Non-transferrin-bound iron was found to be commonly present in African patients with dietary iron overload and to correlate with transferrin saturation and serum ferritin concentration.	Iron	35-39	transferrin	Homo sapiens	17-28
10029292-11	1999	CONCLUSIONS: Non-transferrin-bound iron was found to be commonly present in African patients with dietary iron overload and to correlate with transferrin saturation and serum ferritin concentration.	Iron	35-39	transferrin	Homo sapiens	142-153
10029292-11	1999	CONCLUSIONS: Non-transferrin-bound iron was found to be commonly present in African patients with dietary iron overload and to correlate with transferrin saturation and serum ferritin concentration.	Iron	106-110	transferrin	Homo sapiens	17-28
9989766-0	1999	Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease.	Iron	97-101	transferrin	Homo sapiens	44-55
9989766-0	1999	Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease.	Iron	97-101	transferrin	Homo sapiens	44-55
9989766-3	1999	In the present study we have examined the effect of small molecular weight (M(r)) Fe complexes on Fe uptake from iron 59-labeled transferrin (Tf) and 59Fe-labeled citrate by primary cultures of hepatocytes.	Iron	82-84	transferrin	Homo sapiens	129-140
9989766-5	1999	Preincubation of hepatocytes with the low-M(r) Fe complex ferric ammonium citrate (FAC; 25 microg/mL; (Fe) = 4.4 microg/mL) followed by incubation with 59Fe-Tf or 59Fe-citrate ((Fe) = 0.25 to 25 micromol/L) resulted in the marked stimulation of 59Fe uptake.	Iron	47-49	FA complementation group C	Homo sapiens	83-86
10052358-0	1999	Plants ectopically expressing the iron-binding protein, ferritin, are tolerant to oxidative damage and pathogens.	Iron	34-38	ferritin-1, chloroplastic	Nicotiana tabacum	56-64
9972870-1	1999	It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin.	Iron	88-92	transferrin	Rattus norvegicus	144-155
10052358-1	1999	Transgenic tobacco plants that synthesize alfalfa ferritin in vegetative tissues--either in its processed form in chloroplasts or in the cytoplasmic nonprocessed form--retained photosynthetic function upon free radical toxicity generated by iron excess or paraquat treatment.	Iron	241-245	ferritin-1, chloroplastic	Nicotiana tabacum	50-58
10052358-4	1999	We propose that by sequestering intracellular iron involved in generation of the very reactive hydroxyl radicals through a Fenton reaction, ferritin protects plant cells from oxidative damage induced by a wide range of stresses.	Iron	46-50	ferritin-1, chloroplastic	Nicotiana tabacum	140-148
9924025-0	1999	Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC.	Iron	26-30	iron responsive element binding protein 2	Homo sapiens	65-69
9924025-2	1999	Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool.	Iron	182-186	iron responsive element binding protein 2	Homo sapiens	209-213
10048761-12	1999	Iron supplementation increased MnSOD protein levels and activity in the non-TNF treated cells but did not influence the ability of TNF to induce MnSOD in IEC-6 cells.	Iron	0-4	tumor necrosis factor	Rattus norvegicus	76-79
9892658-1	1999	An early folding event of cytochrome c populates a helix-containing intermediate (INC) because of a pH-dependent misligation between the heme iron and nonnative ligands in the unfolded state (U).	Iron	142-146	cytochrome c, somatic	Homo sapiens	26-38
9878421-4	1999	Nevertheless, addition of heme to two short fragments of cytochrome c enhances helical structure substantially (from approximately 8% to approximately 22%), an effect that depends on iron ligation but not thioether linkage.	Iron	183-187	cytochrome c, somatic	Homo sapiens	57-69
9928993-1	1999	The reaction of human serum apotransferrin with titanium(IV) citrate under physiological conditions results in the formation of a specific bis-titanium(IV) transferrin adduct (Ti2Tf hereafter) with two titanium(IV) ions loaded at the iron binding sites.	Iron	234-238	transferrin	Homo sapiens	31-42
10375303-0	1999	Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein.	Iron	59-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
9873013-10	1999	Spectral binding titrations showed that bulky heme ligands such as clotrimazole bound strongly to TXAS (Kd approximately 0.5 microM), indicating ample space at the distal face of the heme iron.	Iron	188-192	thromboxane A synthase 1	Homo sapiens	98-102
9873059-1	1999	The balance required to maintain appropriate cellular and tissue iron levels has led to the evolution of multiple mechanisms to precisely regulate iron uptake from transferrin and low molecular weight iron chelates.	Iron	65-69	transferrin	Homo sapiens	164-175
9873059-1	1999	The balance required to maintain appropriate cellular and tissue iron levels has led to the evolution of multiple mechanisms to precisely regulate iron uptake from transferrin and low molecular weight iron chelates.	Iron	147-151	transferrin	Homo sapiens	164-175
9873059-1	1999	The balance required to maintain appropriate cellular and tissue iron levels has led to the evolution of multiple mechanisms to precisely regulate iron uptake from transferrin and low molecular weight iron chelates.	Iron	147-151	transferrin	Homo sapiens	164-175
10375303-0	1999	Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein.	Iron	59-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
9920962-0	1999	[The transferrin receptor: its role in iron metabolism and its diagnosis utility].	Iron	39-43	transferrin	Homo sapiens	5-16
10682073-14	1999	Repeat iron studies done 1-7 months post ID (mean: 2.8 months) showed a 1.1-fold to 4.9-fold increase (mean: 1.4-fold) in mean iron levels (40.4 +/- 3.9 mg/dL versus 57.5 +/- 5.5 mg/dL, p = 0.036); a 1.1-fold to 5.2-fold increase (mean: 1.6-fold) in mean transferrin saturation (15.2% +/- 1.3% versus 24.5% +/- 2.6%, p = 0.008); a 1.01-fold to 1.60-fold increase (mean: 1.12-fold) in mean Hct (30.2% +/- 1.37% versus 33.8% +/- 1.5%; p = 0.042).	Iron	7-11	transferrin	Homo sapiens	255-266
10682073-14	1999	Repeat iron studies done 1-7 months post ID (mean: 2.8 months) showed a 1.1-fold to 4.9-fold increase (mean: 1.4-fold) in mean iron levels (40.4 +/- 3.9 mg/dL versus 57.5 +/- 5.5 mg/dL, p = 0.036); a 1.1-fold to 5.2-fold increase (mean: 1.6-fold) in mean transferrin saturation (15.2% +/- 1.3% versus 24.5% +/- 2.6%, p = 0.008); a 1.01-fold to 1.60-fold increase (mean: 1.12-fold) in mean Hct (30.2% +/- 1.37% versus 33.8% +/- 1.5%; p = 0.042).	Iron	127-131	transferrin	Homo sapiens	255-266
9915269-2	1999	EPO resistance is usually attributed to iron or vitamin deficiency, hyperparathyroidism, aluminum toxicity, or inflammation.	Iron	40-44	erythropoietin	Homo sapiens	0-3
9915269-11	1999	In well-dialyzed patients who were iron replete, the acute-phase response was the most important predictor of EPO resistance.	Iron	35-39	erythropoietin	Homo sapiens	110-113
9920962-1	1999	Transferrin receptor is a key protein for the cellular uptake of transferrin iron.	Iron	77-81	transferrin	Homo sapiens	0-11
9920962-1	1999	Transferrin receptor is a key protein for the cellular uptake of transferrin iron.	Iron	77-81	transferrin	Homo sapiens	65-76
9876153-2	1999	For comparison we also determined the Mossbauer spectra of K4 57Fe (CN)6 (potassium ferrocyanide, PFC), where the iron is fully exposed in the same solvent.	Iron	114-118	complement factor properdin	Homo sapiens	98-101
9914472-8	1999	In NaCl/Pi medium containing iron, there was 80% less HDL3 alpha-tocopherol at 60 min, and HDL3 alpha-tocopherol had almost disappeared after 24 h. In this latter condition, the amount of thiobarbituric acid-reactive substances was significantly higher than the respective control HDL3 (P &lt; 0.05) and oxidation of HDL3 by PMA-stimulated PMNs was associated with cross-linking of apoprotein AI, which was detected by SDS/PAGE.	Iron	29-33	HDL3	Homo sapiens	54-58
10604284-0	1999	Alteration of infrared spectrum of serum transferrin by iron binding and lowered pH.	Iron	56-60	transferrin	Homo sapiens	41-52
10604284-1	1999	Difference infrared spectra are reported for human serum transferrin in D2O as a function of iron binding or increased acidity.	Iron	93-97	transferrin	Homo sapiens	57-68
10380081-0	1999	Protonation of porphyrin in iron-free cytochrome c: spectral properties of monocation free base porphyrin, a charge analogue of ferric heme.	Iron	28-32	cytochrome c, somatic	Homo sapiens	38-50
10037058-0	1999	Iron depletion by phlebotomy with recombinant erythropoietin prior to allogeneic transplantation to prevent liver toxicity.	Iron	0-4	erythropoietin	Homo sapiens	46-60
10037058-2	1999	We used subcutaneous recombinant erythropoietin (EPO) (25 UI/kg) three times a week and phlebotomy once a week, to prevent liver toxicity in a patient with advanced acute leukemia and liver disease due to severe iron overload, previous drug toxicity and hepatitis C viral infection.	Iron	212-216	erythropoietin	Homo sapiens	33-47
10728783-1	1999	Heme oxygenase (HO)-1 catalyzes the conversion of heme to biliverdin, iron and carbon monoxide.	Iron	70-74	heme oxygenase 1	Mus musculus	0-21
9914507-1	1999	Iron regulatory proteins (IRP)-1 and 2 are cytoplasmic mRNA-binding proteins that control intracellular iron homeostasis by regulating the translation of ferritin mRNA and stability of transferrin receptor mRNA in an iron-dependent fashion.	Iron	104-108	transferrin	Rattus norvegicus	185-196
9914507-1	1999	Iron regulatory proteins (IRP)-1 and 2 are cytoplasmic mRNA-binding proteins that control intracellular iron homeostasis by regulating the translation of ferritin mRNA and stability of transferrin receptor mRNA in an iron-dependent fashion.	Iron	217-221	transferrin	Rattus norvegicus	185-196
9914472-8	1999	In NaCl/Pi medium containing iron, there was 80% less HDL3 alpha-tocopherol at 60 min, and HDL3 alpha-tocopherol had almost disappeared after 24 h. In this latter condition, the amount of thiobarbituric acid-reactive substances was significantly higher than the respective control HDL3 (P &lt; 0.05) and oxidation of HDL3 by PMA-stimulated PMNs was associated with cross-linking of apoprotein AI, which was detected by SDS/PAGE.	Iron	29-33	HDL3	Homo sapiens	91-95
9914472-8	1999	In NaCl/Pi medium containing iron, there was 80% less HDL3 alpha-tocopherol at 60 min, and HDL3 alpha-tocopherol had almost disappeared after 24 h. In this latter condition, the amount of thiobarbituric acid-reactive substances was significantly higher than the respective control HDL3 (P &lt; 0.05) and oxidation of HDL3 by PMA-stimulated PMNs was associated with cross-linking of apoprotein AI, which was detected by SDS/PAGE.	Iron	29-33	HDL3	Homo sapiens	91-95
9914472-8	1999	In NaCl/Pi medium containing iron, there was 80% less HDL3 alpha-tocopherol at 60 min, and HDL3 alpha-tocopherol had almost disappeared after 24 h. In this latter condition, the amount of thiobarbituric acid-reactive substances was significantly higher than the respective control HDL3 (P &lt; 0.05) and oxidation of HDL3 by PMA-stimulated PMNs was associated with cross-linking of apoprotein AI, which was detected by SDS/PAGE.	Iron	29-33	HDL3	Homo sapiens	91-95
9914472-12	1999	Thus HDL3 is susceptible to oxidative modifications induced by stimulated PMNs, in the presence of an exogenous source of iron.	Iron	122-126	HDL3	Homo sapiens	5-9
9919663-2	1999	The specificity of FpvA was assessed by iron uptake competitions using the wild-type strains P. aeruginosa ATCC 15692 and P. fluorescens ATCC 13525 and their respective ferripyoverdines, and by fpvA gene complementation of a FpvA-deficient mutant of P. aeruginosa ATCC 15692.	Iron	40-44	ferripyoverdine receptor	Pseudomonas aeruginosa PAO1	19-23
9919663-3	1999	The receptor mutant was able to utilize none of the two pyoverdines, while the same but fpvA-complemented mutant recovered simultaneously the ability to incorporate iron thanks to each of the two siderophores.	Iron	165-169	ferripyoverdine receptor	Pseudomonas aeruginosa PAO1	88-92
9919663-4	1999	The broad specificity of recognition of FpvA is viewed as an advantage for the strain in iron competition.	Iron	89-93	ferripyoverdine receptor	Pseudomonas aeruginosa PAO1	40-44
10352380-7	1999	These results indicate that the response to intravenous iron therapy in pregnancy anemia is related to Hb1 level and gestational age at the onset of treatment and probably depends on the erythropoietin response to anemia.	Iron	56-60	histocompatibility minor HB-1	Homo sapiens	103-106
10440237-1	1999	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA binding proteins that posttranscriptionally regulate the expression of mRNAs coding for proteins involved in the maintenance of iron and energy homeostasis.	Iron	185-189	iron responsive element binding protein 2	Homo sapiens	43-47
10580641-6	1999	In addition, with the identification of the transferrin receptor as a protein capable of interacting with HFE we are now beginning to understand how a protein with the structural characteristics of an MHC class I molecule can influence cellular iron homeostasis.	Iron	245-249	transferrin	Homo sapiens	44-55
9880816-3	1999	Metal reconstitution experiments of the SOD with Fe or Mn showed that only the Fe-reconstituted SOD was active.	Iron	49-51	shikimate dehydrogenase	Saccharolobus solfataricus	40-43
10065630-14	1999	Although the association of NRAMP1 with autoimmune disease susceptibility may be related to any one of the multiple pleiotropic effects associated with macrophage activation, the function of NRAMP1 as an iron transporter now prompts more interesting speculation that regulation of iron transport may contribute directly to the disease phenotype in arthritic disease.	Iron	204-208	solute carrier family 11 member 1	Homo sapiens	191-197
9867873-2	1999	Iron regulatory proteins (IRP1 and IRP2) are redox-sensitive RNA-binding proteins that modulate the expression of several genes encoding key proteins of iron metabolism.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	35-39
9867873-2	1999	Iron regulatory proteins (IRP1 and IRP2) are redox-sensitive RNA-binding proteins that modulate the expression of several genes encoding key proteins of iron metabolism.	Iron	153-157	iron responsive element binding protein 2	Homo sapiens	35-39
9880816-3	1999	Metal reconstitution experiments of the SOD with Fe or Mn showed that only the Fe-reconstituted SOD was active.	Iron	49-51	shikimate dehydrogenase	Saccharolobus solfataricus	96-99
9880816-3	1999	Metal reconstitution experiments of the SOD with Fe or Mn showed that only the Fe-reconstituted SOD was active.	Iron	79-81	shikimate dehydrogenase	Saccharolobus solfataricus	40-43
9880816-3	1999	Metal reconstitution experiments of the SOD with Fe or Mn showed that only the Fe-reconstituted SOD was active.	Iron	79-81	shikimate dehydrogenase	Saccharolobus solfataricus	96-99
9880816-5	1999	The Fe-reconstituted SOD was extremely resistant to thermal denaturation; e.g. 96% of the initial activity was retained after heating at 95 degreesC for 2 h. Fe-reconstituted SOD was not inhibited by azide, but fluoride inhibition was observed.	Iron	4-6	shikimate dehydrogenase	Saccharolobus solfataricus	21-24
9880816-5	1999	The Fe-reconstituted SOD was extremely resistant to thermal denaturation; e.g. 96% of the initial activity was retained after heating at 95 degreesC for 2 h. Fe-reconstituted SOD was not inhibited by azide, but fluoride inhibition was observed.	Iron	4-6	shikimate dehydrogenase	Saccharolobus solfataricus	175-178
9880816-5	1999	The Fe-reconstituted SOD was extremely resistant to thermal denaturation; e.g. 96% of the initial activity was retained after heating at 95 degreesC for 2 h. Fe-reconstituted SOD was not inhibited by azide, but fluoride inhibition was observed.	Iron	158-160	shikimate dehydrogenase	Saccharolobus solfataricus	21-24
9880816-5	1999	The Fe-reconstituted SOD was extremely resistant to thermal denaturation; e.g. 96% of the initial activity was retained after heating at 95 degreesC for 2 h. Fe-reconstituted SOD was not inhibited by azide, but fluoride inhibition was observed.	Iron	158-160	shikimate dehydrogenase	Saccharolobus solfataricus	175-178
10090500-0	1999	Elevated non-transferrin bound iron in the lungs of patients with Pneumocystis carinii pneumonia.	Iron	31-35	transferrin	Homo sapiens	13-24
9884342-10	1999	Growth retardation, anemia, iron deposition, and vulnerability to stressful injury are all characteristics observed in recently described HO-1 targeted mice.	Iron	28-32	heme oxygenase 1	Mus musculus	138-142
10445042-3	1999	Key amino acid contacts within the CYP51 active site appear to orientate lanosterol for oxidative attack at the C14-methyl group, and the position of the substrate relative to the haem moiety is consistent with the phenyl-iron complexation studies reported by Tuck et al.	Iron	222-226	sterol 14-demethylase	Saccharomyces cerevisiae S288C	35-40
10090500-7	1999	Moreover, our results suggest that this iron is non-transferrin bound.	Iron	40-44	transferrin	Homo sapiens	52-63
10090500-8	1999	CONCLUSION: Non-transferrin bound iron is increased in the lower respiratory tracts of PCP patients.	Iron	34-38	transferrin	Homo sapiens	16-27
10378873-0	1999	Differential effects of iron load on basal and interferon-gamma plus lipopolysaccharide enhance anticryptococcal activity by the murine microglial cell line BV-2.	Iron	24-28	interferon gamma	Mus musculus	47-63
17312669-0	1999	Myocardial release of non-transferrin-bound iron during cardio-pulmonary bypass surgery.	Iron	44-48	transferrin	Homo sapiens	26-37
10378873-1	1999	Here we evaluated the influence of intracellular iron levels on the constitutive and interferon (IFN)-gamma plus lipopolysaccharide (LPS) enhanced anticryptococcal activity by the murine microglial cell line BV-2.	Iron	49-53	interferon gamma	Mus musculus	85-107
10378873-2	1999	We demonstrated that iron loading via ferric nitrilotriacetate (FeNTA) resulted in a significant increase in the constitutive levels of anticryptococcal activity, while the enhancing effects by IFN-gamma plus LPS were prevented.	Iron	21-25	interferon gamma	Mus musculus	194-203
10378873-3	1999	Accordingly, a major increase was observed in the levels of thiobarbituric reactive substance (TBARS) produced upon iron loading under basal conditions, whereas IFN-gamma plus LPS treatment, that per se did not affect TBARS production, prevented by about 50% the enhancement otherwise occurring in response to iron loading.	Iron	116-120	interferon gamma	Mus musculus	161-170
10378873-3	1999	Accordingly, a major increase was observed in the levels of thiobarbituric reactive substance (TBARS) produced upon iron loading under basal conditions, whereas IFN-gamma plus LPS treatment, that per se did not affect TBARS production, prevented by about 50% the enhancement otherwise occurring in response to iron loading.	Iron	310-314	interferon gamma	Mus musculus	161-170
10599866-3	1999	Iron-induced cytotoxicity was also antagonized by superoxide dismutase with catalase.	Iron	0-4	catalase	Rattus norvegicus	76-84
17312669-2	1999	Since desferrioxamine administration attenuates this syndrome, non-transferrin-bound-iron (NTBI) released into the perfusing medium during CABG was implicated as a catalyst for oxygen radical formation.	Iron	85-89	transferrin	Homo sapiens	67-78
17312669-14	1999	The role of iron in reperfusion injury has been implicated by indirect evidence: during the reperfusion syndrome, the binding of iron with the chelator desferrioxamine (Ambrosio, Zweier et al., 1987; Bel, Martinod et al., 1996), or the administration of exogenous apo-transferrin, improved cardiac contractility and delayed manifestations of cardiac injury (Tiede, Sareen et al., 1990).	Iron	12-16	transferrin	Homo sapiens	268-279
17312669-14	1999	The role of iron in reperfusion injury has been implicated by indirect evidence: during the reperfusion syndrome, the binding of iron with the chelator desferrioxamine (Ambrosio, Zweier et al., 1987; Bel, Martinod et al., 1996), or the administration of exogenous apo-transferrin, improved cardiac contractility and delayed manifestations of cardiac injury (Tiede, Sareen et al., 1990).	Iron	129-133	transferrin	Homo sapiens	268-279
17312669-15	1999	Iron, as a transition metal, is able to catalyze free radical formation when released into the circulation from endogenous stores as non-transferrin-bound-iron (NTBI).	Iron	0-4	transferrin	Homo sapiens	137-148
17312675-0	1999	Removal of non-transferrin-bound iron from blood with iron overload using a device with immobilized desferrioxamine.	Iron	33-37	transferrin	Homo sapiens	15-26
17312675-0	1999	Removal of non-transferrin-bound iron from blood with iron overload using a device with immobilized desferrioxamine.	Iron	54-58	transferrin	Homo sapiens	15-26
17312675-2	1999	When blood circulates through the fibers having pores with 30 kD cut-off, non-transferrin-bound-iron (NTBI) crosses the fiber pores and is chelated by the immobilized desferrioxamine.	Iron	96-100	transferrin	Homo sapiens	78-89
17312675-5	1999	We attribute the inability to remove more serum iron to irreversible iron binding by transferrin.	Iron	69-73	transferrin	Homo sapiens	85-96
10050100-0	1999	How to save money for erythropoietin therapy by changing from "roller coaster" to continuous iron supplementation.	Iron	93-97	erythropoietin	Homo sapiens	22-36
9950149-7	1999	IRP-1 activity and TfR Bmax for diferric transferrin were greater in the iron-deficient group (P&lt;0.05).	Iron	73-77	transferrin	Homo sapiens	41-52
10366015-4	1999	The transferrin receptor has been implicated as a possible mediator of this iron accumulation in the parkinsonian substantia nigra.	Iron	76-80	transferrin	Rattus norvegicus	4-15
10408606-0	1999	Cerebellar granule cells acquire transferrin-free iron by a carrier-mediated process.	Iron	50-54	transferrin	Homo sapiens	33-44
10408606-1	1999	In this study, the mechanism of transferrin-free iron uptake by brain neuronal cells was investigated using the cultured cerebellar granule cells.	Iron	49-53	transferrin	Homo sapiens	32-43
10408606-3	1999	After five days of plating, the cells were incubated with different concentrations of transferrin-free iron in isotonic sucrose solution at different temperatures for a certain time.	Iron	103-107	transferrin	Homo sapiens	86-97
10408606-4	1999	The cellular transferrin-free iron uptake was analysed by measuring the cellular radioactivity with a gamma-counter.	Iron	30-34	transferrin	Homo sapiens	13-24
10408606-5	1999	The result showed that the cultured cerebellar granule cells had the capacity to acquire transferrin-free iron at pH 6.5, at which it was demonstrated that transferrin binds iron very poorly and only very little transferrin can be internalized by reticulocytes and HeLa cells.	Iron	106-110	transferrin	Homo sapiens	89-100
10408606-5	1999	The result showed that the cultured cerebellar granule cells had the capacity to acquire transferrin-free iron at pH 6.5, at which it was demonstrated that transferrin binds iron very poorly and only very little transferrin can be internalized by reticulocytes and HeLa cells.	Iron	106-110	transferrin	Homo sapiens	156-167
10408606-5	1999	The result showed that the cultured cerebellar granule cells had the capacity to acquire transferrin-free iron at pH 6.5, at which it was demonstrated that transferrin binds iron very poorly and only very little transferrin can be internalized by reticulocytes and HeLa cells.	Iron	106-110	transferrin	Homo sapiens	156-167
10408606-5	1999	The result showed that the cultured cerebellar granule cells had the capacity to acquire transferrin-free iron at pH 6.5, at which it was demonstrated that transferrin binds iron very poorly and only very little transferrin can be internalized by reticulocytes and HeLa cells.	Iron	174-178	transferrin	Homo sapiens	156-167
10408606-5	1999	The result showed that the cultured cerebellar granule cells had the capacity to acquire transferrin-free iron at pH 6.5, at which it was demonstrated that transferrin binds iron very poorly and only very little transferrin can be internalized by reticulocytes and HeLa cells.	Iron	174-178	transferrin	Homo sapiens	156-167
10408606-8	1999	These characteristics of transferrin-free iron uptake by the cultured cerebellar granule cells observed in this study, similar to those obtained from cells outside of the brain, implied that a carrier-mediated iron transport system might be present on the membrane of this type of brain neuronal cells.	Iron	42-46	transferrin	Homo sapiens	25-36
10408606-8	1999	These characteristics of transferrin-free iron uptake by the cultured cerebellar granule cells observed in this study, similar to those obtained from cells outside of the brain, implied that a carrier-mediated iron transport system might be present on the membrane of this type of brain neuronal cells.	Iron	210-214	transferrin	Homo sapiens	25-36
27415805-4	1999	Iron deficient DBA mice had significantly lower D2 receptor densities in the frontal cortex (FC) and caudate putamen (CP) (19 vs. 35fmol/mg and 145 vs. 215 fmol/mg, respectively).	Iron	0-4	dopamine receptor D2	Mus musculus	48-59
10069070-0	1999	Iron homeostasis alteration in transgenic tobacco overexpressing ferritin.	Iron	0-4	ferritin-1, chloroplastic	Nicotiana tabacum	65-73
10069070-7	1999	Ferritin overaccumulation in transgenic tobacco leaves leads to an illegitimate iron sequestration.	Iron	80-84	ferritin-1, chloroplastic	Nicotiana tabacum	0-8
9990321-10	1998	In the last step, the monoferric and diferric proteins attain their final state of equilibrium in about 15,000 s. The overall mechanism of iron uptake by ovotransferrin is similar but not identical to those of serum transferrin and lactoferrin.	Iron	139-143	transferrin	Homo sapiens	157-168
18212409-1	1999	Iron Supplementation is crucial in raising hematocrit as well as dosage saving for recombinant human erythropoietin therapy (rHuEPO) in maintenance hemodialysis patients.	Iron	0-4	erythropoietin	Homo sapiens	101-115
18212409-4	1999	In this study we found that 1000 mg of element iron (given as iron saccharate) per moth was effective in maintaining hematocrit and hemoglobin at 33% and 110 gm/L respectively, and reducing the erythropoietin (EPO) dosage by about 20% in maintenance hemodialysis patients who were iron-replete.	Iron	47-51	erythropoietin	Homo sapiens	194-208
18212409-4	1999	In this study we found that 1000 mg of element iron (given as iron saccharate) per moth was effective in maintaining hematocrit and hemoglobin at 33% and 110 gm/L respectively, and reducing the erythropoietin (EPO) dosage by about 20% in maintenance hemodialysis patients who were iron-replete.	Iron	47-51	erythropoietin	Homo sapiens	210-213
18212409-4	1999	In this study we found that 1000 mg of element iron (given as iron saccharate) per moth was effective in maintaining hematocrit and hemoglobin at 33% and 110 gm/L respectively, and reducing the erythropoietin (EPO) dosage by about 20% in maintenance hemodialysis patients who were iron-replete.	Iron	62-66	erythropoietin	Homo sapiens	194-208
18212409-4	1999	In this study we found that 1000 mg of element iron (given as iron saccharate) per moth was effective in maintaining hematocrit and hemoglobin at 33% and 110 gm/L respectively, and reducing the erythropoietin (EPO) dosage by about 20% in maintenance hemodialysis patients who were iron-replete.	Iron	62-66	erythropoietin	Homo sapiens	210-213
11498837-9	1999	Stimulation of erythropoiesis by Epo increased the expression of TfR mRNA, indicating that its expression in erythroid cells was regulated by the level of intracellular iron and the synthesis of heme.	Iron	169-173	erythropoietin	Homo sapiens	33-36
9865721-4	1998	The iron chelator deferoxamine induced both HIF-1alpha and p53, but p53 up-regulation could still be detected in HIF-1alpha-deficient cells, suggesting that mechanisms other than HIF-1alpha activation contribute to oxygen-regulated p53 induction.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
9865721-4	1998	The iron chelator deferoxamine induced both HIF-1alpha and p53, but p53 up-regulation could still be detected in HIF-1alpha-deficient cells, suggesting that mechanisms other than HIF-1alpha activation contribute to oxygen-regulated p53 induction.	Iron	4-8	tumor protein p53	Homo sapiens	59-62
10334668-3	1999	iron is required by the majority of haemodialysis patients receiving epoetin.	Iron	0-4	erythropoietin	Homo sapiens	69-76
10334670-10	1999	Detection and correction of iron deficiency is important to achieve the full benefits of epoetin, though recommendations cannot yet be made regarding the optimum route and timing of iron supplementation in patients with progressive renal insufficiency.	Iron	28-32	erythropoietin	Homo sapiens	89-96
10022330-9	1998	Transferrin capacity is saturated after the absorption of a toxic dose resulting in much of the circulating iron being hydrated ferric ion.	Iron	108-112	transferrin	Homo sapiens	0-11
9887470-5	1998	Genetic testing and measurement of transferrin saturation provide the means to carry out widespread testing for the prevention of iron overload and its clinical consequences.	Iron	130-134	transferrin	Homo sapiens	35-46
9855631-3	1998	Experiments were carried out to attempt to link CYP2E1, iron, and oxidative stress as a potential mechanism by which iron increases ethanol toxicity.	Iron	117-121	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	48-54
9826428-3	1998	Therefore, we investigated the role of GSH and iron in the induction of iNOS in A549 cells by crocidolite.	Iron	47-51	nitric oxide synthase 2	Homo sapiens	72-76
9826428-4	1998	Iron was required for the induction of iNOS by crocidolite.	Iron	0-4	nitric oxide synthase 2	Homo sapiens	39-43
9826428-5	1998	A fivefold higher amount of chrysotile asbestos (3% iron by weight) was required to cause a similar decrease in intracellular GSH and induction of iNOS.	Iron	52-56	nitric oxide synthase 2	Homo sapiens	147-151
9851861-5	1998	A cross-linked, high-molecular-weight derivative of soybean trypsin inhibitor (hMW-SBTI) which was unable to pass through the elevating FE blocked the loss of both immunoreactivity and the sperm binding activity of the FE, but did not inhibit the vitelline delaminase activity that has been implicated in FE formation.	Iron	219-221	kunitz trypsin protease inhibitor	Glycine max	60-77
9851861-5	1998	A cross-linked, high-molecular-weight derivative of soybean trypsin inhibitor (hMW-SBTI) which was unable to pass through the elevating FE blocked the loss of both immunoreactivity and the sperm binding activity of the FE, but did not inhibit the vitelline delaminase activity that has been implicated in FE formation.	Iron	219-221	kunitz trypsin protease inhibitor	Glycine max	60-77
9851049-0	1998	Both the full-length and the N-terminal domain of the meningococcal transferrin-binding protein B discriminate between human iron-loaded and apo-transferrin.	Iron	125-129	transferrin	Homo sapiens	68-79
9851049-1	1998	We have readdressed the ability of the transferrin-binding protein B (TbpB) from Neisseria meningitidis to discriminate between the iron-loaded and the iron-free human transferrin (hTf) by using the BIAcore technology, a powerful experimental technique for the observation of direct interactions between a receptor and its ligands, without the use of labels.	Iron	132-136	transferrin	Homo sapiens	39-50
9851049-1	1998	We have readdressed the ability of the transferrin-binding protein B (TbpB) from Neisseria meningitidis to discriminate between the iron-loaded and the iron-free human transferrin (hTf) by using the BIAcore technology, a powerful experimental technique for the observation of direct interactions between a receptor and its ligands, without the use of labels.	Iron	152-156	transferrin	Homo sapiens	39-50
9851740-0	1998	Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron.	Iron	114-118	interleukin 1 beta	Homo sapiens	61-78
9851740-0	1998	Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron.	Iron	114-118	tumor necrosis factor	Homo sapiens	83-110
9851740-3	1998	We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs.	Iron	37-41	tumor necrosis factor	Homo sapiens	76-103
9851740-3	1998	We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs.	Iron	37-41	tumor necrosis factor	Homo sapiens	105-114
9851740-3	1998	We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs.	Iron	37-41	interleukin 1 beta	Homo sapiens	120-138
9851740-3	1998	We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs.	Iron	37-41	interleukin 1 beta	Homo sapiens	140-149
9851740-9	1998	The addition of FeCl3 to DFA diminished the augmenting effect on the release of IL-1-beta, suggesting that the mechanism of action involved iron chelation.	Iron	140-144	interleukin 1 beta	Homo sapiens	80-89
9851740-10	1998	Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea.	Iron	32-36	interleukin 1 beta	Homo sapiens	73-82
9851740-10	1998	Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea.	Iron	32-36	tumor necrosis factor	Homo sapiens	87-96
9884238-0	1998	Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily.	Iron	21-25	siderophore transporter	Saccharomyces cerevisiae S288C	66-70
9884238-7	1998	Functional complementation of one mutant allowed the identification of the SIT1 gene (Siderophore Iron Transport) encoding a putative permease belonging to the major facilitator superfamily.	Iron	98-102	siderophore transporter	Saccharomyces cerevisiae S288C	75-79
9837812-2	1998	The nuclear-encoded NDUFS8 (TYKY) subunit of complex I is highly conserved among eukaryotes and prokaryotes and contains two 4Fe4S ferredoxin consensus patterns, which have long been thought to provide the binding site for the iron-sulfur cluster N-2.	Iron	227-231	NADH:ubiquinone oxidoreductase core subunit S8	Homo sapiens	20-26
9837812-2	1998	The nuclear-encoded NDUFS8 (TYKY) subunit of complex I is highly conserved among eukaryotes and prokaryotes and contains two 4Fe4S ferredoxin consensus patterns, which have long been thought to provide the binding site for the iron-sulfur cluster N-2.	Iron	227-231	NADH:ubiquinone oxidoreductase core subunit S8	Homo sapiens	28-32
9826428-9	1998	These observations suggest that the induction of iNOS resulted from a decrease in intracellular GSH and the presence of iron from the asbestos fibers.	Iron	120-124	nitric oxide synthase 2	Homo sapiens	49-53
9868172-7	1998	Multiple factors modulate the RNA binding activity of IRP1 and/or IRP2 including iron, nitric oxide, phosphorylation by protein kinase C, oxidative stress and hypoxia/reoxygenation.	Iron	81-85	iron responsive element binding protein 2	Homo sapiens	66-70
9855631-12	1998	These results suggest that elevated generation of reactive oxygen species in HepG2 cells expressing CYP2E1 leads to lipid peroxidation in the presence of iron, and the ensuing prooxidative state damages mitochondria, releasing factors that activate caspase 3, leading to a loss in cell viability and DNA fragmentation.	Iron	154-158	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	100-106
9813017-8	1998	Homologues of Ssq1p and Jac1p are found in bacteria in close association with genes proposed to be involved in iron-sulfur protein biosynthesis.	Iron	111-115	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	14-19
9884584-0	1998	Interaction of the hemochromatosis gene product HFE with transferrin receptor modulates cellular iron metabolism.	Iron	97-101	transferrin	Homo sapiens	57-68
10933425-14	1998	Iron status as measured by haematocrit, serum iron, transferrin saturation and ZPP values was inversely related to MBL.	Iron	0-4	transferrin	Homo sapiens	52-63
9813017-10	1998	Nfs1p is homologous to cysteine desulfurase enzymes that function in iron-sulfur cluster assembly and is also predicted to be mitochondrial.	Iron	69-73	cysteine desulfurase	Saccharomyces cerevisiae S288C	0-5
9813017-12	1998	Taken together these results suggest a role for Ssq1p, Jac1p, and Nfs1p in assembly/maturation of mitochondrial iron-sulfur proteins and that one or more of the target Fe/S proteins contribute to oxidative damage in cells lacking copper/zinc SOD.	Iron	112-116	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	48-53
9813017-12	1998	Taken together these results suggest a role for Ssq1p, Jac1p, and Nfs1p in assembly/maturation of mitochondrial iron-sulfur proteins and that one or more of the target Fe/S proteins contribute to oxidative damage in cells lacking copper/zinc SOD.	Iron	112-116	cysteine desulfurase	Saccharomyces cerevisiae S288C	66-71
9751792-1	1998	Transferrin, a glycoprotein involved in iron transport in body fluids, was isolated from amniotic fluid of a hydramniospatient by sequential anion-exchange chromatography and gel filtration.	Iron	40-44	transferrin	Homo sapiens	0-11
9822159-0	1998	Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid.	Iron	57-61	transferrin	Rattus norvegicus	39-50
9822159-1	1998	Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers.	Iron	25-29	transferrin	Rattus norvegicus	0-11
9822159-1	1998	Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers.	Iron	25-29	transferrin	Rattus norvegicus	13-15
9822159-1	1998	Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers.	Iron	25-29	transferrin	Rattus norvegicus	93-95
9822159-1	1998	Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers.	Iron	31-33	transferrin	Rattus norvegicus	0-11
9822159-1	1998	Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers.	Iron	31-33	transferrin	Rattus norvegicus	13-15
9822159-1	1998	Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers.	Iron	31-33	transferrin	Rattus norvegicus	93-95
9822159-2	1998	As Tf transport through the brain barriers is restricted, Fe is probably released into the brain extracellular compartment as non-Tf-bound iron (NTBI).	Iron	58-60	transferrin	Rattus norvegicus	130-132
9822159-6	1998	Measurements of Fe and Tf concentrations in CSF of P20 rats revealed that the Fe-binding capacity of Tf was exceeded.	Iron	16-18	heat shock protein family B (small) member 6	Rattus norvegicus	51-54
9822159-6	1998	Measurements of Fe and Tf concentrations in CSF of P20 rats revealed that the Fe-binding capacity of Tf was exceeded.	Iron	16-18	transferrin	Rattus norvegicus	101-103
9822159-6	1998	Measurements of Fe and Tf concentrations in CSF of P20 rats revealed that the Fe-binding capacity of Tf was exceeded.	Iron	78-80	transferrin	Rattus norvegicus	23-25
9822159-6	1998	Measurements of Fe and Tf concentrations in CSF of P20 rats revealed that the Fe-binding capacity of Tf was exceeded.	Iron	78-80	heat shock protein family B (small) member 6	Rattus norvegicus	51-54
9822159-6	1998	Measurements of Fe and Tf concentrations in CSF of P20 rats revealed that the Fe-binding capacity of Tf was exceeded.	Iron	78-80	transferrin	Rattus norvegicus	101-103
9858760-5	1998	The results suggest that active sites of lipoxygenase-1 containing iron cofactor are situated in a limited region of the enzyme molecule that is more fragile to denaturants than the protein as a whole.	Iron	67-71	seed linoleate 13S-lipoxygenase-1	Glycine max	41-55
9894741-0	1998	Iron in the treatment of anemia in dialysis patients: an important support to erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	78-92
9951916-0	1998	The effect of interferon and desferrioxamine on serum ferritin and hepatic iron concentrations in chronic hepatitis B. BACKGROUND/AIMS: Recent reports indicate that an individual"s iron status might affect the response rate achieved with Interferon therapy for the treatment of chronic viral hepatitis.	Iron	181-185	interferon alpha 1	Homo sapiens	14-24
9951916-0	1998	The effect of interferon and desferrioxamine on serum ferritin and hepatic iron concentrations in chronic hepatitis B. BACKGROUND/AIMS: Recent reports indicate that an individual"s iron status might affect the response rate achieved with Interferon therapy for the treatment of chronic viral hepatitis.	Iron	181-185	interferon alpha 1	Homo sapiens	238-248
9784581-2	1998	Zrt1, Zrt2 and Zip1-4 are probably zinc transporters in Saccharomyces cerevisiae and Arabidopsis thaliana whereas Irt1 appears to play a role in iron uptake in A. thaliana.	Iron	145-149	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	0-4
9807056-0	1998	Intravenous low-dose iron administration in hemodialysis patients treated with erythropoietin.	Iron	21-25	erythropoietin	Homo sapiens	79-93
9844132-12	1998	CONCLUSION: Cytochrome P-450, a group of heme proteins, may serve as a significant source of catalytic iron in cisplatin-induced nephrotoxicity.	Iron	103-107	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	12-28
9808632-3	1998	In addition, recent observations based on positional cloning strategies in the mk/mk mouse and the Belgrade (b/b) rat rodent models of hypochromic, microcytic anemia have shown that the phenotypic abnormality in iron metabolism is associated with a mutation in the Nramp2 gene.	Iron	212-216	solute carrier family 11 member 2	Rattus norvegicus	265-271
9844132-0	1998	Role of cytochrome P-450 as a source of catalytic iron in cisplatin-induced nephrotoxicity.	Iron	50-54	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	8-24
9804609-3	1998	Expression of HIF-1 and downstream genes can also be induced by exposure of cells to divalent metals (such as CoCl2) or iron chelators [such as desferrioxamine (DFO)].	Iron	120-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-19
9797798-9	1998	Although daily oral iron supplementation was given, mean serum ferritin levels declined by approximately 75% through day 22 in subjects treated with multiple doses of epoetin alfa.	Iron	20-24	erythropoietin	Homo sapiens	167-174
9829492-1	1998	BACKGROUND: Functional iron deficiency may develop and cause erythropoietin resistance in haemodialysis patients with iron overload.	Iron	23-27	erythropoietin	Homo sapiens	61-75
9829492-19	1998	Our study draws attention to a potential adjuvant therapy, intravenous ascorbic acid, to treat erythropoietin-hyporesponsive anaemia in iron-overloaded patients.	Iron	136-140	erythropoietin	Homo sapiens	95-109
9760252-2	1998	The rates of iron removal from Tf/2N by 3-hydroxypyridin-4-one (deferiprone) and nitrilotriacetic acid (NTA) are essentially identical with previous results on N-terminal monoferric transferrin (Tf-FeN).	Iron	13-17	transferrin	Homo sapiens	182-193
9769372-1	1998	Transferrin is a serum glycoprotein involved in iron transport.	Iron	48-52	transferrin	Homo sapiens	0-11
10083891-9	1998	The use of EPO can be optimized by taking into consideration some predicting factors, by modulating the dose and by using iron support.	Iron	122-126	erythropoietin	Homo sapiens	11-14
9760232-3	1998	To help define the steps in iron release, we have determined the three-dimensional structure of the iron-free (apo) form of the recombinant N-lobe half-molecule of human serum transferrin (ApoTfN) by X-ray crystallography.	Iron	28-32	transferrin	Homo sapiens	176-187
9760232-3	1998	To help define the steps in iron release, we have determined the three-dimensional structure of the iron-free (apo) form of the recombinant N-lobe half-molecule of human serum transferrin (ApoTfN) by X-ray crystallography.	Iron	100-104	transferrin	Homo sapiens	176-187
9746792-8	1998	Iron released in the form of LMW-Fe readily binds to plasma transferrin and may contribute to the high transferrin saturation and the occurrence of circulating nontransferrin-bound iron observed in HH patients.	Iron	0-4	transferrin	Homo sapiens	60-71
9746792-8	1998	Iron released in the form of LMW-Fe readily binds to plasma transferrin and may contribute to the high transferrin saturation and the occurrence of circulating nontransferrin-bound iron observed in HH patients.	Iron	0-4	transferrin	Homo sapiens	103-114
9746792-8	1998	Iron released in the form of LMW-Fe readily binds to plasma transferrin and may contribute to the high transferrin saturation and the occurrence of circulating nontransferrin-bound iron observed in HH patients.	Iron	181-185	transferrin	Homo sapiens	60-71
9761244-6	1998	One of these women exhibited an increased total transferrin concentration (mean value, 5.38 g/L), which was possibly related to the use of oral contraceptives and/or a low serum iron concentration.	Iron	178-182	transferrin	Homo sapiens	48-59
9766445-0	1998	Modulation of iron metabolism in monocytic THP-1 cells and cultured human monocytes by the acute-phase protein alpha1-antitrypsin.	Iron	14-18	serpin family A member 1	Homo sapiens	111-129
9788892-6	1998	In the rat model, a relationship exists between the ability of various dusts to cause PMN recruitment or protein leakage into the alveolar space and the induction of iNOS message in BALC, i.e., silica &gt; coal mine dust &gt; carbonyl iron &gt; titanium dioxide.	Iron	235-239	nitric oxide synthase 2	Rattus norvegicus	166-170
9766445-2	1998	We previously reported that the acute-phase protein alpha1-antitrypsin (alpha1-AT) reduced growth and proliferation in cells of the erythroid cell system by interfering with transferrin (Tf)-mediated iron uptake.	Iron	200-204	serpin family A member 1	Homo sapiens	52-70
9766445-2	1998	We previously reported that the acute-phase protein alpha1-antitrypsin (alpha1-AT) reduced growth and proliferation in cells of the erythroid cell system by interfering with transferrin (Tf)-mediated iron uptake.	Iron	200-204	serpin family A member 1	Homo sapiens	72-81
9766445-2	1998	We previously reported that the acute-phase protein alpha1-antitrypsin (alpha1-AT) reduced growth and proliferation in cells of the erythroid cell system by interfering with transferrin (Tf)-mediated iron uptake.	Iron	200-204	transferrin	Homo sapiens	174-185
9766445-2	1998	We previously reported that the acute-phase protein alpha1-antitrypsin (alpha1-AT) reduced growth and proliferation in cells of the erythroid cell system by interfering with transferrin (Tf)-mediated iron uptake.	Iron	200-204	transferrin	Homo sapiens	187-189
9766445-3	1998	The regulation of iron metabolism in cells of the RE system is distinctly different from that in other cell systems; moreover, monocytes and macrophages play an essential part in the regulation of the production and clearance of alpha1-AT.	Iron	18-22	serpin family A member 1	Homo sapiens	229-238
9766445-13	1998	These data provide further evidence that alpha1-AT is a mediator of the alterations in iron metabolism characteristic of ACD.	Iron	87-91	serpin family A member 1	Homo sapiens	41-50
9804503-0	1998	Erythropoietin (EPO) requirements remain high in EPO resistant patients after iron repletion.	Iron	78-82	erythropoietin	Homo sapiens	0-14
9794562-3	1998	iron therapy at 20 mg three times per week post-dialysis based on the presence of at least one of the following iron metabolism markers: percentage of transferrin saturation (%TSAT) &lt;20%; percentage of hypochromic erythrocytes (%HypoE) &gt; 10% and serum ferritin (SF) &lt;400 microg/l.	Iron	0-4	transferrin	Homo sapiens	151-162
9794563-0	1998	The absorption of iron is disturbed in recombinant human erythropoietin-treated peritoneal dialysis patients.	Iron	18-22	erythropoietin	Homo sapiens	57-71
9794563-1	1998	BACKGROUND: Intravenous iron supplementation is often necessary in recombinant human erythropoietin (r-HuEPO)-treated haemodialysis (HD) patients, but rarely in r-HuEPO-treated peritoneal dialysis (PD) patients.	Iron	24-28	erythropoietin	Homo sapiens	85-99
9726965-9	1998	Variations in IRE structure and cellular IRP1/IRP2 ratios can provide a range of finely tuned, mRNA-specific responses to the same (iron) signal.	Iron	132-136	iron responsive element binding protein 2	Homo sapiens	46-50
9726978-1	1998	The high affinity uptake systems for iron and copper ions in Saccharomyces cerevisiae involve metal-specific permeases and two known cell surface Cu(II) and Fe(III) metalloreductases, Fre1 and Fre2.	Iron	37-41	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	184-188
9699464-3	1998	The addition of the second polyanion to a solution of ferric cytochrome c at a low ionic strength, pH 7.0, resulted in profound conformational change in the hydrophobic core of protein (opening of the heme crevice with a perturbation of the methionine 80-heme iron bond and the hydrophobic core of the protein).	Iron	260-264	cytochrome c, somatic	Homo sapiens	61-73
9751080-4	1998	The role of iron-catalyzed free radical reactions in the pathology of dystrophin-deficient muscle was evaluated in the murine model for Duchenne muscular dystrophy (mdx), by examining the effects of dietary deficiency and supplementation of iron on serum creatine kinase (CK), muscle morphology, lipid peroxidation and HSP levels in mice maintained on diets deficient in or supplemented with iron for 6 weeks.	Iron	12-16	dystrophin, muscular dystrophy	Mus musculus	70-80
9751080-5	1998	Iron-deprived mdx mice showed a significant decrease in the number of macrophage-invaded necrotic fibers and the expression of the 70-kDa heat shock protein (Hsp70).	Iron	0-4	heat shock protein 1B	Mus musculus	158-163
9751080-6	1998	This suggests that the iron-dependent generation of .OH relates to muscle necrosis in the mdx mouse and modulates the expression of Hsp70 in vivo.	Iron	23-27	heat shock protein 1B	Mus musculus	132-137
9804503-0	1998	Erythropoietin (EPO) requirements remain high in EPO resistant patients after iron repletion.	Iron	78-82	erythropoietin	Homo sapiens	16-19
9741591-7	1998	This suggests that the peroxidase activity of cytochrome c involves substrate-induced loss of the methionine ligand at the iron sixth coordination position, which is favored by interaction of cytochrome c with negatively charged interfaces.	Iron	123-127	cytochrome c, somatic	Homo sapiens	46-58
9726951-9	1998	The splitting in the Q0.0 absorption band and the temperature dependence and splitting of the photoexcited triplet state of myoglobin in which the iron was replaced by Mg2+ are interpreted in terms of effects produced by electric field asymmetry in the heme pocket.	Iron	147-151	myoglobin	Equus caballus	124-133
9741090-0	1998	Human transferrin as a source of iron for Streptococcus intermedius.	Iron	33-37	transferrin	Homo sapiens	6-17
9743172-10	1998	Particularly in CF patients who also demonstrated decreased airway concentrations of transferrin, ferritin-bound iron in airways may promote oxidative injury and enhance bacterial growth.	Iron	113-117	transferrin	Homo sapiens	85-96
9741591-7	1998	This suggests that the peroxidase activity of cytochrome c involves substrate-induced loss of the methionine ligand at the iron sixth coordination position, which is favored by interaction of cytochrome c with negatively charged interfaces.	Iron	123-127	cytochrome c, somatic	Homo sapiens	192-204
11186208-0	1998	Characterization of a transferrin-independent iron uptake system in rat primary cultured cortical cells.	Iron	46-50	transferrin	Rattus norvegicus	22-33
9721738-5	1998	Iron-enriched cells showed a reduction in surface-bound and total transferrin receptor numbers compared with iron-depleted cells.	Iron	0-4	transferrin	Homo sapiens	66-77
9721738-6	1998	Transferrin receptor kinetics showed that the transferrin receptor internalization rate in iron-enriched cultures was higher, whereas the transferrin receptor externalization rate in iron-enriched cultures was lower than the rate in iron-depleted cultures.	Iron	91-95	transferrin	Homo sapiens	0-11
9721738-6	1998	Transferrin receptor kinetics showed that the transferrin receptor internalization rate in iron-enriched cultures was higher, whereas the transferrin receptor externalization rate in iron-enriched cultures was lower than the rate in iron-depleted cultures.	Iron	91-95	transferrin	Homo sapiens	46-57
9721738-6	1998	Transferrin receptor kinetics showed that the transferrin receptor internalization rate in iron-enriched cultures was higher, whereas the transferrin receptor externalization rate in iron-enriched cultures was lower than the rate in iron-depleted cultures.	Iron	183-187	transferrin	Homo sapiens	138-149
9721738-6	1998	Transferrin receptor kinetics showed that the transferrin receptor internalization rate in iron-enriched cultures was higher, whereas the transferrin receptor externalization rate in iron-enriched cultures was lower than the rate in iron-depleted cultures.	Iron	183-187	transferrin	Homo sapiens	138-149
9721738-7	1998	Moreover, blood-brain barrier endothelial cells cultured in iron-enriched medium were able to accumulate more iron intracellularly, which underlines our kinetic data on transferrin receptors.	Iron	60-64	transferrin	Homo sapiens	169-180
9721738-7	1998	Moreover, blood-brain barrier endothelial cells cultured in iron-enriched medium were able to accumulate more iron intracellularly, which underlines our kinetic data on transferrin receptors.	Iron	110-114	transferrin	Homo sapiens	169-180
9727376-10	1998	Exogenous C20:4, as well as PLA2 (in doses simulating Fe-induced deacylation) recapitulated Fe"s ceramide-generating effect.	Iron	54-56	phospholipase A2 group IB	Homo sapiens	28-32
9727376-10	1998	Exogenous C20:4, as well as PLA2 (in doses simulating Fe-induced deacylation) recapitulated Fe"s ceramide-generating effect.	Iron	92-94	phospholipase A2 group IB	Homo sapiens	28-32
9766845-1	1998	Myeloperoxidase (MPO), an iron-containing heme protein localized in the azurophilic granules of neutrophil granulocytes and in the lysosomes of monocytes, is involved in the killing of several micro-organisms and foreign cells, including bacteria, fungi, viruses, red cells, and malignant and nonmalignant nucleated cells.	Iron	26-30	myeloperoxidase	Homo sapiens	0-15
9766845-1	1998	Myeloperoxidase (MPO), an iron-containing heme protein localized in the azurophilic granules of neutrophil granulocytes and in the lysosomes of monocytes, is involved in the killing of several micro-organisms and foreign cells, including bacteria, fungi, viruses, red cells, and malignant and nonmalignant nucleated cells.	Iron	26-30	myeloperoxidase	Homo sapiens	17-20
11186208-1	1998	Multiple transferrin-independent iron uptake (Tf-IU) systems are known to be involved in the internalization of free iron salt in various mammalian cells.	Iron	33-37	transferrin	Homo sapiens	9-20
9748051-3	1998	Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer"s disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.	Iron	44-48	pantothenate kinase 2	Homo sapiens	70-76
9693129-1	1998	Neisseria meningitidis utilization of human serum transferrin (hTF)-bound iron is an important pathogenicity determinant.	Iron	74-78	transferrin	Homo sapiens	50-61
9793069-10	1998	The NO sequestered in Hb is eventually oxidized aerobically to NO3- in the reaction of Fe-NO + O2--&gt;Fe(+) + NO3.	Iron	103-108	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
9793069-10	1998	The NO sequestered in Hb is eventually oxidized aerobically to NO3- in the reaction of Fe-NO + O2--&gt;Fe(+) + NO3.	Iron	103-108	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
10933414-9	1998	Univariate and multivariate analyses revealed significant (P&lt;0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin.	Iron	392-396	fibrinogen beta chain	Homo sapiens	95-105
10933414-10	1998	The correlations with BMI, serum lipoproteins, iron, ferritin, and GGT suggest that nutritional status and therefore diet influences plasma fibrinogen.	Iron	47-51	fibrinogen beta chain	Homo sapiens	140-150
9778126-0	1998	Non-transferrin iron uptake by trophoblast cells in culture.	Iron	16-20	transferrin	Homo sapiens	4-15
9778126-4	1998	Kinetic parameters for non-transferrin iron uptake are determined from initial rate experiments, yielding Vmax=366 pmol/mg protein/5 min and Km=0.96 microM for Fe(III)NTA and Vmax=4043 pmol/mg protein/5 min and Km= 1.3 microM for Fe-ascorbate.	Iron	39-43	transferrin	Homo sapiens	27-38
9778126-11	1998	These results reveal that a transmembrane NADH-dependent ferrireductase plays a role in uptake of non-transferrin iron.	Iron	114-118	transferrin	Homo sapiens	102-113
9705350-0	1998	Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.	Iron	150-154	transferrin	Homo sapiens	97-108
9705206-0	1998	Substrates of hexokinase, glucose-6-phosphate dehydrogenase, and glyceraldehyde-3-phosphate dehydrogenase prevent the inhibitory response induced by ascorbic acid/iron and dehydroascorbic acid in rabbit erythrocytes.	Iron	163-167	hexokinase-2	Oryctolagus cuniculus	14-24
9705206-0	1998	Substrates of hexokinase, glucose-6-phosphate dehydrogenase, and glyceraldehyde-3-phosphate dehydrogenase prevent the inhibitory response induced by ascorbic acid/iron and dehydroascorbic acid in rabbit erythrocytes.	Iron	163-167	glucose-6-phosphate 1-dehydrogenase	Oryctolagus cuniculus	26-59
9739406-12	1998	The increased number of malignant endocervical glands expressing TfR may indicate a special requirement for Tf and the iron that it carries.	Iron	119-123	transferrin	Homo sapiens	65-67
9763218-6	1998	Iron chelation efficiency in the culture model was studied by analyzing the effect of CP20 on radioactive iron uptake, intracellular ferritin level, and transferrin receptor expression.	Iron	0-4	transferrin	Homo sapiens	153-164
9763218-8	1998	Iron chelators inhibited cellular iron uptake, decreased intracellular ferritin level, and increased transferrin receptor protein and mRNA levels.	Iron	0-4	transferrin	Homo sapiens	101-112
9688655-1	1998	The mechanisms of uptake of non-transferrin-bound iron by human hepatoma cells (HuH7) were investigated using 59Fe-citrate and [14C]citrate.	Iron	50-54	transferrin	Homo sapiens	32-43
9744541-12	1998	Furthermore, iron supplemented rats killed at week 31 had significantly higher (P &lt; 0.05) levels of inflammation, cell proliferation, iNOS and nitrotyrosine as well as more tumors in their distal esophagi than did rats that received no iron supplement.	Iron	13-17	nitric oxide synthase 2	Rattus norvegicus	137-141
9827040-6	1998	Hexokinase activity was also reduced by addition of iron/ascorbate, indicating a susceptibility of the enzyme to metal-mediated oxyradical production.	Iron	52-56	hexokinase 1	Homo sapiens	0-10
9673237-0	1998	Receptor-mediated recognition and uptake of iron from human transferrin by Staphylococcus aureus and Staphylococcus epidermidis.	Iron	44-48	transferrin	Homo sapiens	60-71
9680178-9	1998	Lower plasma albumin and transferrin lowered the TRAP and iron binding antioxidant capacity, respectively (r = +0.36, p &lt; .05, and r = +0.41, p &lt; .005).	Iron	58-62	transferrin	Homo sapiens	25-36
9673237-2	1998	In an iron-deficient medium, staphylococcal growth can be promoted by the addition of human diferric transferrin but not human apotransferrin.	Iron	6-10	transferrin	Homo sapiens	101-112
9673237-3	1998	To determine whether the staphylococcal transferrin receptor is involved in the removal of iron from transferrin, we employed 6 M urea-polyacrylamide gel electrophoresis, which separates human transferrin into four forms (diferric, monoferric N-lobe, and monoferric C-lobe transferrin and apotransferrin).	Iron	91-95	transferrin	Homo sapiens	40-51
9673237-6	1998	Metabolic poisons such as sodium azide and nigericin inhibited the release of iron from human transferrin, indicating that it is an energy-requiring process.	Iron	78-82	transferrin	Homo sapiens	94-105
9673237-10	1998	Furthermore, the staphylococci removed iron efficiently from the iron-loaded N-lobe fragment of human transferrin.	Iron	39-43	transferrin	Homo sapiens	102-113
9673237-10	1998	Furthermore, the staphylococci removed iron efficiently from the iron-loaded N-lobe fragment of human transferrin.	Iron	65-69	transferrin	Homo sapiens	102-113
9673237-11	1998	These data demonstrate that the staphylococci efficiently remove iron from transferrin via a receptor-mediated process and provide evidence to suggest that there is a primary receptor recognition site on the N-lobe of human transferrin.	Iron	65-69	transferrin	Homo sapiens	75-86
9673237-11	1998	These data demonstrate that the staphylococci efficiently remove iron from transferrin via a receptor-mediated process and provide evidence to suggest that there is a primary receptor recognition site on the N-lobe of human transferrin.	Iron	65-69	transferrin	Homo sapiens	224-235
9702705-4	1998	Bound transferrin was 280 micrograms/mg of iron.	Iron	43-47	transferrin	Rattus norvegicus	6-17
9708518-13	1998	In vitro experiments demonstrate that the uptake of 67Ga by the transferrin-independent route can be enhanced further to levels that equal or exceed those achieved by the transferrin-dependent route by increasing the content of calcium or iron salts in the incubation medium.	Iron	239-243	transferrin	Homo sapiens	64-75
9725776-1	1998	BACKGROUND: Using an HPLC/ETAAS hybrid speciation technique we previously demonstrated iron to have a multifold effect on the binding of aluminum to transferrin by limiting the number of available binding sites and decreasing the affinity of transferrin for aluminum.	Iron	87-91	transferrin	Homo sapiens	149-160
9725776-1	1998	BACKGROUND: Using an HPLC/ETAAS hybrid speciation technique we previously demonstrated iron to have a multifold effect on the binding of aluminum to transferrin by limiting the number of available binding sites and decreasing the affinity of transferrin for aluminum.	Iron	87-91	transferrin	Homo sapiens	242-253
9725776-2	1998	Theoretically, at a 60% iron-transferrin saturation the aluminum-transferrin fraction in serum should not exceed 30 microg/l.	Iron	24-28	transferrin	Homo sapiens	29-40
9725776-2	1998	Theoretically, at a 60% iron-transferrin saturation the aluminum-transferrin fraction in serum should not exceed 30 microg/l.	Iron	24-28	transferrin	Homo sapiens	65-76
9725776-6	1998	Taking patients of both groups receiving Al(OH)3 together a significant (p = 0.001) negative correlation (r = -0.5017) was found between the iron-transferrin saturation and the serum aluminum levels.	Iron	141-145	transferrin	Homo sapiens	146-157
9725776-8	1998	Since in this population aluminum loading occurred parenterally and not via the gastrointestinal tract, a direct effect of iron on the transferrin binding of aluminum rather than on the element"s gastrointestinal absorption must have been responsible for the inverse relationship.	Iron	123-127	transferrin	Homo sapiens	135-146
9725776-10	1998	On the other hand out of 13 iron overloaded patients (serum ferritin &gt;800 microg/l; iron-transferrin saturation 61.4 +/- 17.6%) 10 (77%) presented the proposed criteria of aluminum overload in the presence of a serum aluminum level &lt;30 microg/l.	Iron	28-32	transferrin	Homo sapiens	92-103
9725776-10	1998	On the other hand out of 13 iron overloaded patients (serum ferritin &gt;800 microg/l; iron-transferrin saturation 61.4 +/- 17.6%) 10 (77%) presented the proposed criteria of aluminum overload in the presence of a serum aluminum level &lt;30 microg/l.	Iron	87-91	transferrin	Homo sapiens	92-103
9725776-11	1998	CONCLUSIONS: Our data indicate that in dialysis patients with iron overload (iron-transferrin saturation &gt;60%; serum ferritin &gt;800 microg/l) serum aluminum levels are low (&lt;30 microg/l) despite exposure to aluminum by the intake of Al(OH)3 or the use of aluminum-contaminated dialysis fluids.	Iron	62-66	transferrin	Homo sapiens	82-93
9725776-11	1998	CONCLUSIONS: Our data indicate that in dialysis patients with iron overload (iron-transferrin saturation &gt;60%; serum ferritin &gt;800 microg/l) serum aluminum levels are low (&lt;30 microg/l) despite exposure to aluminum by the intake of Al(OH)3 or the use of aluminum-contaminated dialysis fluids.	Iron	77-81	transferrin	Homo sapiens	82-93
9690231-14	1998	Also, the dose of erythropoietin was directly associated with the CRP concentration, before (r = 0.081, P = 0.009) and after (t = 2.03, P = 0.042) adjustment for the serum albumin and iron concentrations.	Iron	184-188	erythropoietin	Homo sapiens	18-32
9690231-14	1998	Also, the dose of erythropoietin was directly associated with the CRP concentration, before (r = 0.081, P = 0.009) and after (t = 2.03, P = 0.042) adjustment for the serum albumin and iron concentrations.	Iron	184-188	C-reactive protein	Homo sapiens	66-69
9764408-2	1998	During severe anemia, serum iron was remarkably elevated while the total iron-binding capacity remained relatively unchanged or decreased slightly in the infected calves, resulting in elevated transferrin saturation.	Iron	28-32	serotransferrin	Bos taurus	193-204
9764408-2	1998	During severe anemia, serum iron was remarkably elevated while the total iron-binding capacity remained relatively unchanged or decreased slightly in the infected calves, resulting in elevated transferrin saturation.	Iron	73-77	serotransferrin	Bos taurus	193-204
9660806-0	1998	Mt-Hsp70 homolog, Ssc2p, required for maturation of yeast frataxin and mitochondrial iron homeostasis.	Iron	85-89	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	18-23
9701579-4	1998	Expression of CCH in the atx1 strain restored high-affinity iron uptake, demonstrating that CCH is a functional homolog of ATX1.	Iron	60-64	copper chaperone	Arabidopsis thaliana	14-17
9701579-4	1998	Expression of CCH in the atx1 strain restored high-affinity iron uptake, demonstrating that CCH is a functional homolog of ATX1.	Iron	60-64	copper chaperone	Arabidopsis thaliana	92-95
18967239-9	1998	The selectivity of the method was demonstrated for the analysis of high purity iron; the accuracy for the determination of Ni(II) and Co(II) was 11 and 3%, respectively while the coefficient of variation was 10 and 8%, respectively.	Iron	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
9660756-0	1998	Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein.	Iron	59-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
9660756-0	1998	Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein.	Iron	59-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
9660756-5	1998	Hypoxia, transition metals, iron chelators, and several antioxidants stabilize the HIF-1alpha protein, allowing the formation of the transcriptionally active HIF-1 complex.	Iron	28-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
9660756-9	1998	Measurement of iron in recombinantly expressed HIF-1alpha protein revealed that this protein binds iron in vivo.	Iron	15-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
9660756-9	1998	Measurement of iron in recombinantly expressed HIF-1alpha protein revealed that this protein binds iron in vivo.	Iron	99-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
9660806-1	1998	Here we show that the yeast mitochondrial chaperone Ssc2p, a homolog of mt-Hsp70, plays a critical role in mitochondrial iron homeostasis.	Iron	121-125	Hsp70 family ATPase SSQ1	Saccharomyces cerevisiae S288C	52-57
9660756-10	1998	Iron binding was localized to a 129-amino acid peptide between sequences 529 and 658 of the HIF-1alpha protein.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-102
9660756-12	1998	This finding is compatible with a model where redox reaction may occur directly in the iron center of the HIF-1alpha subunit, affecting its survival in oxic conditions.	Iron	87-91	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
9660806-2	1998	Yeast with ssc2-1 mutations were identified by a screen for altered iron-dependent gene regulation and mitochondrial dysfunction.	Iron	68-72	ELOVL fatty acid elongase 2	Homo sapiens	11-15
9660806-5	1998	Like mutants of yfh1, ssc2-1 mutants accumulate vast quantities of iron in mitochondria.	Iron	67-71	ELOVL fatty acid elongase 2	Homo sapiens	22-26
9660806-7	1998	This function for a mitochondrial Hsp70 chaperone is likely to be conserved, implying that a human homolog of Ssc2p may be involved in iron homeostasis and in neurodegenerative disease.	Iron	135-139	ELOVL fatty acid elongase 2	Homo sapiens	110-115
9665800-1	1998	Transferrin (Tf), an iron-binding protein, was investigated in the cultured human fibroblast which is a major cell type in connective tissues.	Iron	21-25	transferrin	Homo sapiens	0-11
9683524-0	1998	Pitfalls in assessing specificity and affinity of non-transferrin-bound iron uptake.	Iron	72-76	transferrin	Homo sapiens	54-65
9657982-8	1998	Hsp 90 overexpression obtained by challenging the cells with iron was associated with a decreased susceptibility to oxidative inactivation of the MCP trypsin-like activity.	Iron	61-65	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	0-6
9714452-0	1998	Transferrin-bound iron uptake by the cultured cerebellar granule cells.	Iron	18-22	transferrin	Homo sapiens	0-11
9714452-3	1998	In this study, transferrin-bound iron (Tf-Fe) accumulation in the cultured cerebellar granule cell was investigated in vitro.	Iron	33-37	transferrin	Homo sapiens	15-26
9714452-3	1998	In this study, transferrin-bound iron (Tf-Fe) accumulation in the cultured cerebellar granule cell was investigated in vitro.	Iron	33-37	transferrin	Homo sapiens	39-41
9714452-3	1998	In this study, transferrin-bound iron (Tf-Fe) accumulation in the cultured cerebellar granule cell was investigated in vitro.	Iron	42-44	transferrin	Homo sapiens	15-26
9714452-3	1998	In this study, transferrin-bound iron (Tf-Fe) accumulation in the cultured cerebellar granule cell was investigated in vitro.	Iron	42-44	transferrin	Homo sapiens	39-41
9714452-8	1998	Dysfunction of Tf or TfR would possibly lead to iron irregulation in the brain and consequently cause damage to neuronal functions.	Iron	48-52	transferrin	Homo sapiens	15-17
9665800-1	1998	Transferrin (Tf), an iron-binding protein, was investigated in the cultured human fibroblast which is a major cell type in connective tissues.	Iron	21-25	transferrin	Homo sapiens	13-15
9665800-2	1998	Tf is a major iron-transporting protein and has an important role in iron metabolism.	Iron	14-18	transferrin	Homo sapiens	0-2
9797624-0	1998	Iron supplementation enhances response to high doses of recombinant human erythropoietin in preterm infants.	Iron	0-4	erythropoietin	Homo sapiens	74-88
9714332-6	1998	Experiments using a c-Fes mutant that lacked tyrosine kinase activity revealed that the activation of STAT3 is kinase-dependent, but that the c-Fes-STAT3 interaction is not affected by c-Fes tyrosine kinase activity.	Iron	22-25	signal transducer and activator of transcription 3	Homo sapiens	102-107
9642266-2	1998	The x-ray crystal structure of the N-lobe of human serum transferrin has shown that there is a hydrogen bond network, the so-called "second shell," around the transferrin iron binding site.	Iron	171-175	transferrin	Homo sapiens	57-68
9642266-2	1998	The x-ray crystal structure of the N-lobe of human serum transferrin has shown that there is a hydrogen bond network, the so-called "second shell," around the transferrin iron binding site.	Iron	171-175	transferrin	Homo sapiens	159-170
9797624-1	1998	AIMS: To determine whether iron supplementation would enhance erythropoiesis in preterm infants treated with high doses of human recombinant erythropoietin (r-HuEPO).	Iron	27-31	erythropoietin	Homo sapiens	141-155
9639675-2	1998	A chlorpromazine stimulatory effect upon iron uptake from 55Fe-citrate and 55Fe-transferrin by cortical synaptosome preparations of rats was recently demonstrated.	Iron	41-45	transferrin	Rattus norvegicus	80-91
9797624-6	1998	Reticulocyte and haematocrit values from postnatal weeks 5 to 8 were higher in the EPO + iron than in the EPO group, and both groups had higher values than the controls.	Iron	89-93	erythropoietin	Homo sapiens	83-86
9746310-2	1998	In this paper, such a phenomenon was analyzed using the chemical kinetics model of electron transfer from succinate to cytochrome c, including coenzyme Q, the complex III non-heme iron protein FeSIII and cytochromes bl, bh and cl.	Iron	180-184	cytochrome c, somatic	Homo sapiens	119-131
9845473-0	1998	Failure to respond to interferon-alpha 2a therapy is associated with increased hepatic iron levels in patients with chronic hepatitis C. Recent reports suggest the hepatic iron concentration (HIC) may influence the activity of hepatitis and the response to interferon (IFN) therapy in patients with chronic hepatitis C (CH-C).	Iron	172-176	interferon alpha 1	Homo sapiens	269-272
9845473-1	1998	We have evaluated iron status in 28 patients with CH-C and determined if pretreatment iron status can predict the response to IFN-alpha therapy in these patients.	Iron	86-90	interferon alpha 1	Homo sapiens	126-135
9845473-9	1998	Increased hepatic iron stores are associated with poor response to IFN therapy.	Iron	18-22	interferon alpha 1	Homo sapiens	67-70
9726030-0	1998	Regulation of iron metabolism in the acute-phase response: interferon gamma and tumour necrosis factor alpha induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients.	Iron	14-18	transferrin	Homo sapiens	181-192
9726030-10	1998	TNF, possibly via induction of IL-6, and IFN-gamma induce hypoferraemia, which may in part result from a decrease in tissue iron release based on a primary stimulation of ferritin synthesis.	Iron	124-128	tumor necrosis factor	Homo sapiens	0-3
9726030-10	1998	TNF, possibly via induction of IL-6, and IFN-gamma induce hypoferraemia, which may in part result from a decrease in tissue iron release based on a primary stimulation of ferritin synthesis.	Iron	124-128	interferon gamma	Homo sapiens	41-50
9630620-11	1998	These results suggest that intracellular iron transport is highly compartmentalized, that iron released from endosomal transferrin passes to its cellular targets in a direct contact with the endosomal membrane complex assigned as Band I.	Iron	41-45	transferrin	Homo sapiens	119-130
9668540-3	1998	This outpouring of catabolic iron exceeds the iron-binding capacity of transferrin and appears in plasma as non-transferrin-plasma iron (NTPI).	Iron	29-33	transferrin	Homo sapiens	112-123
9668540-3	1998	This outpouring of catabolic iron exceeds the iron-binding capacity of transferrin and appears in plasma as non-transferrin-plasma iron (NTPI).	Iron	46-50	transferrin	Homo sapiens	71-82
9668540-3	1998	This outpouring of catabolic iron exceeds the iron-binding capacity of transferrin and appears in plasma as non-transferrin-plasma iron (NTPI).	Iron	46-50	transferrin	Homo sapiens	71-82
9668540-4	1998	The toxicity of NTPI is much higher than of transferrin-iron as judged by its ability to promote hydroxyl radical formation resulting in peroxidative damage to membrane lipids and proteins.	Iron	56-60	transferrin	Homo sapiens	44-55
9630620-11	1998	These results suggest that intracellular iron transport is highly compartmentalized, that iron released from endosomal transferrin passes to its cellular targets in a direct contact with the endosomal membrane complex assigned as Band I.	Iron	90-94	transferrin	Homo sapiens	119-130
9624120-1	1998	In vitro studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits (H-Ft) and a nucleation center associated with ferritin L subunits (L-Ft).	Iron	42-46	ferritin mitochondrial	Mus musculus	115-125
9616166-0	1998	Transferrin receptor-dependent and -independent iron transport in gallium-resistant human lymphoid leukemic cells.	Iron	48-52	transferrin	Homo sapiens	0-11
9855066-1	1998	BACKGROUND/AIMS: The present study was designed to investigate whether the acute phase protein alpha-1-antitrypsin (alpha1-AT), which has an inhibitory effect on transferrin (tf) receptor-mediated iron uptake in K562 and THP1 cells, has a similar effect in PLC/PRF/5 cells.	Iron	197-201	serpin family A member 1	Homo sapiens	95-114
9667777-6	1998	The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.	Iron	96-98	amyloid beta precursor protein	Homo sapiens	150-162
9630632-1	1998	We have cloned and characterized the ACO2 gene on human chromosome 22q13, which encodes the essential iron-dependent metabolic enzyme mitochondrial aconitase.	Iron	102-106	aconitase 2	Homo sapiens	37-41
9630632-1	1998	We have cloned and characterized the ACO2 gene on human chromosome 22q13, which encodes the essential iron-dependent metabolic enzyme mitochondrial aconitase.	Iron	102-106	aconitase 2	Homo sapiens	134-157
9609685-0	1998	Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.	Iron	127-131	transferrin	Homo sapiens	74-85
9635730-0	1998	The pH-induced release of iron from transferrin investigated with a continuum electrostatic model.	Iron	26-30	transferrin	Homo sapiens	36-47
9635730-1	1998	A reduction in pH induces the release of iron from transferrin in a process that involves a conformational change in the protein from a closed to an open form.	Iron	41-45	transferrin	Homo sapiens	51-62
9635730-3	1998	Such changes in protonation states of residues and the consequent changes in electrostatic interactions are assumed to play a large part in the mechanism of release of iron from transferrin.	Iron	168-172	transferrin	Homo sapiens	178-189
9631540-0	1998	Iron repressibility of siderophore and transferrin-binding protein in Staphylococcus aureus.	Iron	0-4	transferrin	Homo sapiens	39-50
9631540-1	1998	In order to investigate whether the iron acquisition mechanisms of Staphylococcus aureus are induced by iron restriction in vitro, we examined S. aureus ATCC 6538 for production of siderophore and expression of transferrin-binding protein (SA-tbp) in normal or deferrated brain heart infusion broth (BHI).	Iron	36-40	transferrin	Homo sapiens	211-222
9631540-5	1998	In conclusion, both iron acquisition mechanisms of S. aureus were found to be iron-repressible and via both of them, human transferrin-bound iron was utilized for growth under iron-restricted condition.	Iron	20-24	transferrin	Homo sapiens	123-134
9631540-5	1998	In conclusion, both iron acquisition mechanisms of S. aureus were found to be iron-repressible and via both of them, human transferrin-bound iron was utilized for growth under iron-restricted condition.	Iron	78-82	transferrin	Homo sapiens	123-134
9631540-5	1998	In conclusion, both iron acquisition mechanisms of S. aureus were found to be iron-repressible and via both of them, human transferrin-bound iron was utilized for growth under iron-restricted condition.	Iron	78-82	transferrin	Homo sapiens	123-134
9631540-5	1998	In conclusion, both iron acquisition mechanisms of S. aureus were found to be iron-repressible and via both of them, human transferrin-bound iron was utilized for growth under iron-restricted condition.	Iron	78-82	transferrin	Homo sapiens	123-134
9641269-9	1998	The data are consistent with the possibility that the combination of increased redox-active iron and elevated H2O2 in the plasmodium-infected Tg-CuZnSOD mice, led to an enhanced Fenton"s reaction-mediated HO.	Iron	92-96	superoxide dismutase 1, soluble	Mus musculus	142-152
9657901-5	1998	Iron uptake by lens epithelial cells from 59ferric chloride was 20 times higher than from 59iron-transferrin and iron deposition into ferritin was 8-fold higher when 59ferric chloride was the source.	Iron	0-4	transferrin	Homo sapiens	97-108
9657901-5	1998	Iron uptake by lens epithelial cells from 59ferric chloride was 20 times higher than from 59iron-transferrin and iron deposition into ferritin was 8-fold higher when 59ferric chloride was the source.	Iron	92-96	transferrin	Homo sapiens	97-108
9657901-6	1998	Ascorbic acid had a stimulatory effect on iron uptake from transferrin and on incorporation of this element into ferritin.	Iron	42-46	transferrin	Homo sapiens	59-70
9657901-10	1998	Ferric ammonium citrate activates iron uptake from transferrin in a wide range of cell lines by generation of free radicals.	Iron	34-38	transferrin	Homo sapiens	51-62
9657901-16	1998	In addition, the differences in iron uptake from transferrin and ferric chloride and its subsequent incorporation into ferritin suggests that the mechanisms by which iron is incorporated into ferritin are source dependent.	Iron	166-170	transferrin	Homo sapiens	49-60
9855066-1	1998	BACKGROUND/AIMS: The present study was designed to investigate whether the acute phase protein alpha-1-antitrypsin (alpha1-AT), which has an inhibitory effect on transferrin (tf) receptor-mediated iron uptake in K562 and THP1 cells, has a similar effect in PLC/PRF/5 cells.	Iron	197-201	serpin family A member 1	Homo sapiens	116-125
9855066-1	1998	BACKGROUND/AIMS: The present study was designed to investigate whether the acute phase protein alpha-1-antitrypsin (alpha1-AT), which has an inhibitory effect on transferrin (tf) receptor-mediated iron uptake in K562 and THP1 cells, has a similar effect in PLC/PRF/5 cells.	Iron	197-201	transferrin	Homo sapiens	162-173
9610360-0	1998	Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site.	Iron	117-121	peptide deformylase	Escherichia coli	73-92
9620327-3	1998	Iron overload was defined as a raised serum ferritin concentration in combination with a transferrin saturation &gt; or = 60%, and was confirmed histologically when possible.	Iron	0-4	transferrin	Homo sapiens	89-100
11670409-12	1998	pM values calculated under physiological conditions for DTPA, TTHA, and the bis(butanamide) derivatives have shown that while DTPA remains a ligand of choice to chelate Fe(3+) and In(3+) ions in vivo compared to transferrin as competitor ligand, TTHA, surprisingly, appears to be the best of these four ligands (pM = 22.71) to chelate Ga(3+).	Iron	169-171	transferrin	Homo sapiens	212-223
9766237-0	1998	Cooperation between the components of the meningococcal transferrin receptor, TbpA and TbpB, in the uptake of transferrin iron by the 37-kDa ferric-binding protein (FbpA).	Iron	122-126	transferrin	Homo sapiens	56-67
9766237-0	1998	Cooperation between the components of the meningococcal transferrin receptor, TbpA and TbpB, in the uptake of transferrin iron by the 37-kDa ferric-binding protein (FbpA).	Iron	122-126	transferrin	Homo sapiens	110-121
9766237-1	1998	Meningococcal TbpAB complexes TbpA, TbpB and FbpA were purified and used to study their role in the uptake of iron from transferrin to FbpA.	Iron	110-114	transferrin	Homo sapiens	120-131
9766237-4	1998	FbpA was able to bind iron from transferrin only when TbpAB complexes, TbpA and/or TbpB, were also present during the interaction.	Iron	22-26	transferrin	Homo sapiens	32-43
9766237-6	1998	We conclude that the TbpA and TbpB molecules form true functional transferrin receptors, that FbpA is able to take iron directly from transferrin when in the presence of the components of the receptor, and that both Tbps are necessary for an optimal operation of the uptake system.	Iron	115-119	transferrin	Homo sapiens	134-145
9610362-0	1998	Targeting human breast cancer cells that overexpress HER-2/neu mRNA by an antisense iron responsive element.	Iron	84-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-62
9610362-3	1998	To target the breast cancer cells overexpressing HER-2/neu mRNA, a novel approach is described that combines the antisense principle and the biochemical property of a translation regulator, an iron responsive element (IRE).	Iron	193-197	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-58
9620956-1	1998	Pathogenic members of the family Neisseriaceae produce specific receptors facilitating iron acquisition from transferrin (Tf) and lactoferrin (Lf) of their mammalian host.	Iron	87-91	transferrin	Homo sapiens	109-120
9620956-1	1998	Pathogenic members of the family Neisseriaceae produce specific receptors facilitating iron acquisition from transferrin (Tf) and lactoferrin (Lf) of their mammalian host.	Iron	87-91	transferrin	Homo sapiens	122-124
9715407-2	1998	To characterize the defect of iron metabolism responsible for this disease, this study localized and semi-quantified the mRNA and protein expression of transferrin, transferrin receptor and ferritin in the liver and duodenum of patients with genetic haemochromatosis.	Iron	30-34	transferrin	Homo sapiens	152-163
9715407-2	1998	To characterize the defect of iron metabolism responsible for this disease, this study localized and semi-quantified the mRNA and protein expression of transferrin, transferrin receptor and ferritin in the liver and duodenum of patients with genetic haemochromatosis.	Iron	30-34	transferrin	Homo sapiens	165-176
9715407-10	1998	Early in the course of genetic haemochromatosis and before the onset of hepatic fibrosis, transferrin receptor-mediated iron uptake by hepatocytes contributes to hepatic iron overload.	Iron	120-124	transferrin	Homo sapiens	90-101
9715407-10	1998	Early in the course of genetic haemochromatosis and before the onset of hepatic fibrosis, transferrin receptor-mediated iron uptake by hepatocytes contributes to hepatic iron overload.	Iron	170-174	transferrin	Homo sapiens	90-101
9575215-3	1998	There are two known IRPs, IRP1 and IRP2, both of which can respond to iron fluxes in the cell.	Iron	70-74	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	26-30
9573037-1	1998	The Caco-2 cell line grown in bicameral chambers was used to study the effect of transferrin in the basal chamber on the transepithelial transport of iron.	Iron	150-154	transferrin	Homo sapiens	81-92
9575215-4	1998	There is ample evidence that IRP1 is converted by iron to cytoplasmic aconitase in vivo.	Iron	50-54	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	29-33
9576849-10	1998	The induction of p53 by H2O2 was abolished by the iron chelator deferoxamine and the protein synthesis inhibitor cycloheximide.	Iron	50-54	tumor protein p53	Homo sapiens	17-20
9575215-5	1998	It has also been shown that, under certain conditions, a significant fraction of IRP1 is degraded in cells exposed to iron or heme.	Iron	118-122	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	81-85
9575215-6	1998	Studies have shown that the degradation of IRP1 that is induced by iron can be inhibited by either desferrioxamine mesylate (an iron chelator) or succinyl acetone (an inhibitor of heme synthesis), whereas the degradation induced by heme cannot.	Iron	67-71	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	43-47
9575215-6	1998	Studies have shown that the degradation of IRP1 that is induced by iron can be inhibited by either desferrioxamine mesylate (an iron chelator) or succinyl acetone (an inhibitor of heme synthesis), whereas the degradation induced by heme cannot.	Iron	128-132	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	43-47
9575215-11	1998	However, as shown earlier with IRP1, both desferrioxamine mesylate and succinyl acetone will inhibit the degradation of IRP2 induced by iron but not that induced by heme.	Iron	136-140	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	31-35
9590194-0	1998	Effect of an intravenous iron dextran regimen on iron stores, hemoglobin, and erythropoietin requirements in hemodialysis patients.	Iron	25-29	erythropoietin	Homo sapiens	78-92
9671336-6	1998	Does "functional iron deficiency" complicate epoetin alfa therapy of patients with the anemia of cancer, and could such patients benefit from iron supplementation?	Iron	17-21	erythropoietin	Homo sapiens	45-52
9590194-3	1998	Intravenous (IV) iron dextran may be an effective alternative approach to replete iron stores and may facilitate more cost-effective use of EPO.	Iron	17-21	erythropoietin	Homo sapiens	140-143
9590194-9	1998	Thirty hemodialysis patients receiving EPO were identified as being iron deficient and were enrolled in the study.	Iron	68-72	erythropoietin	Homo sapiens	39-42
9590194-15	1998	The administration of the IV iron dextran regimen in the iron-deficient hemodialysis population was effective at repleting and maintaining iron stores and reducing EPO use.	Iron	29-33	erythropoietin	Homo sapiens	164-167
9590194-15	1998	The administration of the IV iron dextran regimen in the iron-deficient hemodialysis population was effective at repleting and maintaining iron stores and reducing EPO use.	Iron	57-61	erythropoietin	Homo sapiens	164-167
9558386-5	1998	The involvement of a heme protein in the hypoxia-induced expression of uPAR was suggested by the observations that culture of cells with cobalt chloride, or sodium 4, 5-dihydroxybenzene-1,3-disulfonate (Tiron), an iron-chelating agent, also stimulated uPAR expression, and that the hypoxia-induced uPAR expression was inhibited by adding carbon monoxide to the hypoxic atmosphere.	Iron	204-208	plasminogen activator, urokinase	Homo sapiens	71-75
9673397-5	1998	The addition of exogenous iron as transferrin-iron to the culture medium reversed the cytotoxicity of gallium nitrate and PIH in a dose-dependent manner but had only minor effects on the cytotoxicity of Ga-PIH.	Iron	26-30	transferrin	Homo sapiens	34-45
9673397-5	1998	The addition of exogenous iron as transferrin-iron to the culture medium reversed the cytotoxicity of gallium nitrate and PIH in a dose-dependent manner but had only minor effects on the cytotoxicity of Ga-PIH.	Iron	46-50	transferrin	Homo sapiens	34-45
9609543-0	1998	Non-transferrin bound iron induced by myeloablative therapy.	Iron	22-26	transferrin	Homo sapiens	4-15
9719948-8	1998	Although the changes in GABA concentrations in corresponding brain regions were not observed, the activities of the GABA-synthesizing enzyme GAD and GABA-degrading enzyme GABA-T of the rats fed iron-depleted diets for 6 weeks decreased significantly.	Iron	194-198	4-aminobutyrate aminotransferase	Rattus norvegicus	171-177
9658731-9	1998	Diagnosis of iron overload can be suspected on the basis of clinical data, high transferrin saturation and/or serum ferritin values.	Iron	13-17	transferrin	Homo sapiens	80-91
9659170-5	1998	METHODS: Serum levels of TIMP-1, MMP-1, MMP-2, and MMP-3 were measured by enzyme immunoassay and correlated to hepatic iron concentration and degree of histological fibrosis.	Iron	119-123	TIMP metallopeptidase inhibitor 1	Homo sapiens	25-31
9659170-8	1998	Serum TIMP-1 concentration correlated with both hepatic iron concentration and hepatic iron index (r = 0.42, p &lt; 0.01; r = 0.42, p &lt; 0.01).	Iron	56-60	TIMP metallopeptidase inhibitor 1	Homo sapiens	6-12
9659170-8	1998	Serum TIMP-1 concentration correlated with both hepatic iron concentration and hepatic iron index (r = 0.42, p &lt; 0.01; r = 0.42, p &lt; 0.01).	Iron	87-91	TIMP metallopeptidase inhibitor 1	Homo sapiens	6-12
9572292-1	1998	Heme oxygenase isozymes, HO-1 (also known as hsp32) and HO-2, are the source for the formation of the putative messenger molecule carbon monoxide (CO), reactive iron, and the in vitro antioxidant bilirubin.	Iron	161-165	heme oxygenase 1	Mus musculus	25-29
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	13-17	transferrin	Homo sapiens	206-217
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	74-78	transferrin	Homo sapiens	206-217
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	74-78	transferrin	Homo sapiens	206-217
9572292-1	1998	Heme oxygenase isozymes, HO-1 (also known as hsp32) and HO-2, are the source for the formation of the putative messenger molecule carbon monoxide (CO), reactive iron, and the in vitro antioxidant bilirubin.	Iron	161-165	heme oxygenase 1	Mus musculus	45-50
9602126-1	1998	Serum transferrin is the protein whose primary function is to bind iron and transport it through the blood.	Iron	67-71	transferrin	Homo sapiens	6-17
9545294-11	1998	Spectroscopic evidence presented here demonstrates that XylT reactivates XylE through reduction of the iron atom in the active site of the enzyme.	Iron	103-107	ferredoxin	Pseudomonas putida	56-60
9554960-1	1998	The plant-type ubiquinol:oxygen oxidoreductase, commonly called the alternative oxidase, is a respiratory enzyme thought to contain non-heme iron at its active site.	Iron	141-145	oxidoreductase	Arabidopsis thaliana	32-46
9560204-0	1998	Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	61-86
9560204-2	1998	Iron uptake and distribution is regulated tightly in mammalian cells, in part by iron regulatory protein 2 (IRP2), a protein that is degraded efficiently by the proteasome in iron-replete cells.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	81-106
9560204-2	1998	Iron uptake and distribution is regulated tightly in mammalian cells, in part by iron regulatory protein 2 (IRP2), a protein that is degraded efficiently by the proteasome in iron-replete cells.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	108-112
9560204-2	1998	Iron uptake and distribution is regulated tightly in mammalian cells, in part by iron regulatory protein 2 (IRP2), a protein that is degraded efficiently by the proteasome in iron-replete cells.	Iron	81-85	iron responsive element binding protein 2	Homo sapiens	108-112
9560204-4	1998	Moreover, iron-dependent oxidation converts IRP2 into a substrate for ubiquitination in vitro.	Iron	10-14	iron responsive element binding protein 2	Homo sapiens	44-48
9560204-5	1998	A regulatory pathway is described in which excess iron is sensed by its ability to catalyze site-specific oxidations in IRP2, oxidized IRP2 is ubiquitinated, and ubiquitinated IRP2 subsequently is degraded by the proteasome.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	120-124
9560204-5	1998	A regulatory pathway is described in which excess iron is sensed by its ability to catalyze site-specific oxidations in IRP2, oxidized IRP2 is ubiquitinated, and ubiquitinated IRP2 subsequently is degraded by the proteasome.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	135-139
9560204-5	1998	A regulatory pathway is described in which excess iron is sensed by its ability to catalyze site-specific oxidations in IRP2, oxidized IRP2 is ubiquitinated, and ubiquitinated IRP2 subsequently is degraded by the proteasome.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	135-139
9545264-1	1998	Iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	35-39
9545264-1	1998	Iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	95-99	iron responsive element binding protein 2	Homo sapiens	35-39
9542060-8	1998	The role of iron was confirmed by the inhibiting effect of metal-free transferrin on iron-dependent ascorbate oxidation.	Iron	12-16	transferrin	Homo sapiens	70-81
9542060-8	1998	The role of iron was confirmed by the inhibiting effect of metal-free transferrin on iron-dependent ascorbate oxidation.	Iron	85-89	transferrin	Homo sapiens	70-81
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Iron	138-142	transferrin	Rattus norvegicus	199-210
9578471-3	1998	Consequently, the liver, which is the major site of iron storage, will be presented with iron in both transferrin-bound and non-transferrin-bound forms and these forms may compete for uptake by hepatocytes.	Iron	52-56	transferrin	Rattus norvegicus	102-113
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Iron	138-142	transferrin	Rattus norvegicus	199-210
9578471-3	1998	Consequently, the liver, which is the major site of iron storage, will be presented with iron in both transferrin-bound and non-transferrin-bound forms and these forms may compete for uptake by hepatocytes.	Iron	89-93	transferrin	Rattus norvegicus	102-113
9578471-3	1998	Consequently, the liver, which is the major site of iron storage, will be presented with iron in both transferrin-bound and non-transferrin-bound forms and these forms may compete for uptake by hepatocytes.	Iron	89-93	transferrin	Rattus norvegicus	128-139
9578471-13	1998	These data suggest that citrate-mediated iron uptake by hepatocytes shares at least one common pathway with transferrin-mediated iron uptake.	Iron	129-133	transferrin	Rattus norvegicus	108-119
9578471-4	1998	The endogenous low-molecular-mass iron chelator, citrate, is considered to be a major contributing molecule to non-transferrin iron transport.	Iron	34-38	transferrin	Rattus norvegicus	115-126
9579879-0	1998	The estimation of efficacy of oral iron supplementation during treatment with epoetin beta (recombinant human erythropoietin) in patients undergoing cardiac surgery.	Iron	35-39	erythropoietin	Homo sapiens	110-124
9555668-1	1998	Hemodialysis patients treated with recombinant human erythropoietin (rhEPO) need adequate iron supplementation to avoid rhEPO hyporesponsiveness due to iron deficiency.	Iron	90-94	erythropoietin	Homo sapiens	53-67
9537448-6	1998	We also demonstrate exchange of iron between DTPA and holo-transferrin, or at least movement from the chelator to the protein, which may have lost its iron to the cell in advance, providing new binding sites for mobilized iron.	Iron	32-36	transferrin	Rattus norvegicus	59-70
9537448-6	1998	We also demonstrate exchange of iron between DTPA and holo-transferrin, or at least movement from the chelator to the protein, which may have lost its iron to the cell in advance, providing new binding sites for mobilized iron.	Iron	151-155	transferrin	Rattus norvegicus	59-70
9537448-6	1998	We also demonstrate exchange of iron between DTPA and holo-transferrin, or at least movement from the chelator to the protein, which may have lost its iron to the cell in advance, providing new binding sites for mobilized iron.	Iron	151-155	transferrin	Rattus norvegicus	59-70
9537448-10	1998	We conclude that this activity represents a hitherto unidentified first step in the movement of iron through the cell membrane and may be relevant for transferrin-bound, as well as for non-transferrin-bound, iron uptake by hepatocytes.	Iron	96-100	transferrin	Rattus norvegicus	151-162
9537448-10	1998	We conclude that this activity represents a hitherto unidentified first step in the movement of iron through the cell membrane and may be relevant for transferrin-bound, as well as for non-transferrin-bound, iron uptake by hepatocytes.	Iron	96-100	transferrin	Rattus norvegicus	189-200
9537448-10	1998	We conclude that this activity represents a hitherto unidentified first step in the movement of iron through the cell membrane and may be relevant for transferrin-bound, as well as for non-transferrin-bound, iron uptake by hepatocytes.	Iron	208-212	transferrin	Rattus norvegicus	189-200
9510527-5	1998	In addition to erythropoietin, HIF-1-responsive genes include examples with functions in cellular energy metabolism, iron metabolism, catecholamine metabolism, vasomotor control and angiogenesis, suggesting an important role in the coordination of oxygen supply and cellular metabolism.	Iron	117-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-36
9537326-3	1998	The hypoxic state can be mimicked by using cobalt chloride and the iron chelator desferrioxamine: like hypoxia, cobalt chloride and desferrioxamine activate hypoxia-inducible factor 1alpha (HIF-1alpha), which stimulates the transcription of several genes that are associated with hypoxia.	Iron	67-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-188
9516467-11	1998	The strength of the anaerobic repression was dependent on the low affinity, Fe(II)-specific iron transporter, encoded by FET4, suggesting that this Fe(II) pool was linked in part to iron brought into the cell via Fet4 protein.	Iron	92-96	Fet4p	Saccharomyces cerevisiae S288C	121-125
9516467-11	1998	The strength of the anaerobic repression was dependent on the low affinity, Fe(II)-specific iron transporter, encoded by FET4, suggesting that this Fe(II) pool was linked in part to iron brought into the cell via Fet4 protein.	Iron	92-96	Fet4p	Saccharomyces cerevisiae S288C	213-217
9578471-7	1998	Binding and internalisation of both citrate and iron were inhibited in a dose-dependent manner with increasing concentration of diferric transferrin, with iron uptake decreasing to less than 5% of control values.	Iron	48-52	transferrin	Rattus norvegicus	137-148
9578471-7	1998	Binding and internalisation of both citrate and iron were inhibited in a dose-dependent manner with increasing concentration of diferric transferrin, with iron uptake decreasing to less than 5% of control values.	Iron	155-159	transferrin	Rattus norvegicus	137-148
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Iron	138-142	transferrin	Rattus norvegicus	94-105
9555030-2	1998	We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis.	Iron	50-54	iron responsive element binding protein 2	Homo sapiens	156-161
9555030-2	1998	We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis.	Iron	107-111	iron responsive element binding protein 2	Homo sapiens	156-161
9555030-2	1998	We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis.	Iron	107-111	iron responsive element binding protein 2	Homo sapiens	156-161
9555030-4	1998	Since IRP-2 colocalizes with redox-active iron, our results suggest that alterations in IRP-2 might be directly linked to impaired iron homeostasis in Alzheimer"s disease.	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	88-93
9537326-3	1998	The hypoxic state can be mimicked by using cobalt chloride and the iron chelator desferrioxamine: like hypoxia, cobalt chloride and desferrioxamine activate hypoxia-inducible factor 1alpha (HIF-1alpha), which stimulates the transcription of several genes that are associated with hypoxia.	Iron	67-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	190-200
9559540-6	1998	The SCS7 gene encodes a protein that contains both a cytochrome b5-like domain and a domain that resembles the family of cytochrome b5-dependent enzymes that use iron and oxygen to catalyse desaturation or hydroxylation of fatty acids and sterols.	Iron	162-166	fatty acid alpha-hydroxylase	Saccharomyces cerevisiae S288C	4-8
9506995-13	1998	A current model for both transferrin- and nontransferrin-bound Fe uptake involves the function of a ferrireductase that acts to reduce Fe3+ to Fe2+, with subsequent transport of the divalent cation across the membrane bilayer.	Iron	63-65	transferrin	Homo sapiens	25-36
9539161-0	1998	Iron attenuates nitric oxide level and iNOS expression in endotoxin-treated mice.	Iron	0-4	nitric oxide synthase 2, inducible	Mus musculus	39-43
9539161-5	1998	The iNOS protein determination in the liver tissue of LPS-treated mice demonstrated iron-dependent inhibition of iNOS expression.	Iron	84-88	nitric oxide synthase 2, inducible	Mus musculus	4-8
9539161-5	1998	The iNOS protein determination in the liver tissue of LPS-treated mice demonstrated iron-dependent inhibition of iNOS expression.	Iron	84-88	nitric oxide synthase 2, inducible	Mus musculus	113-117
9539161-7	1998	This is a first report demonstrating iron-dependent iNOS down-regulation in endotoxin-treated mice.	Iron	37-41	nitric oxide synthase 2, inducible	Mus musculus	52-56
9545519-0	1998	Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture.	Iron	42-46	transferrin	Rattus norvegicus	24-35
9545552-1	1998	Low molecular mass iron (LMrFe) can appear in plasma when the transferrin becomes fully iron loaded.	Iron	19-23	transferrin	Homo sapiens	62-73
9545552-1	1998	Low molecular mass iron (LMrFe) can appear in plasma when the transferrin becomes fully iron loaded.	Iron	88-92	transferrin	Homo sapiens	62-73
9530175-8	1998	Relative to saline instillation, transferrin was significantly diminished after exposure to the iron-containing particle, whereas both lactoferrin and transferrin receptor concentrations in the segment of the lung exposed to the particle were significantly elevated.	Iron	96-100	transferrin	Homo sapiens	33-44
9502420-0	1998	Accumulation of iron by primary rat hepatocytes in long-term culture: changes in nuclear shape mediated by non-transferrin-bound forms of iron.	Iron	138-142	transferrin	Rattus norvegicus	111-122
9502420-2	1998	Hepatocytes in long-term DMSO culture can be iron loaded by exposure to non-transferrin-bound iron (NTBI) in the form of ferrous sulfate (FeSO4), ferric nitrilotriacetate, or trimethylhexanoyl (TMH)-ferrocene.	Iron	45-49	transferrin	Rattus norvegicus	76-87
9502420-2	1998	Hepatocytes in long-term DMSO culture can be iron loaded by exposure to non-transferrin-bound iron (NTBI) in the form of ferrous sulfate (FeSO4), ferric nitrilotriacetate, or trimethylhexanoyl (TMH)-ferrocene.	Iron	94-98	transferrin	Rattus norvegicus	76-87
9545519-1	1998	Under conditions of iron overload plasma transferrin can be fully saturated and the plasma can transport non-transferrin-bound Fe which is rapidly cleared by the liver.	Iron	20-24	transferrin	Rattus norvegicus	41-52
9545519-1	1998	Under conditions of iron overload plasma transferrin can be fully saturated and the plasma can transport non-transferrin-bound Fe which is rapidly cleared by the liver.	Iron	127-129	transferrin	Rattus norvegicus	109-120
9545519-11	1998	These experiments show that rat hepatocytes in primary culture have a high capacity to take up non-transferrin-bound Fe in the form of Fe-citrate and that uptake occurs by facilitated diffusion.	Iron	117-119	transferrin	Rattus norvegicus	99-110
9559866-0	1998	Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload.	Iron	109-113	superoxide dismutase 1	Rattus norvegicus	72-97
9526125-8	1998	These results show that oxidation of iron has little effect on the N- and C-terminal regions, but significantly destabilizes the interior regions of cytochrome c.	Iron	37-41	cytochrome c, somatic	Homo sapiens	149-161
9495013-1	1998	The human transferrin receptor, a type II plasma membrane protein which mediates iron transport in human cells, was expressed in the yeast Saccharomyces cerevisiae.	Iron	81-85	transferrin	Homo sapiens	10-21
9490593-8	1998	RESULTS: Gross iron overload (elevated transferrin saturation and ferritin levels) was proven by liver biopsy and phlebotomy treatment in 28 participants (0.4% of female outpatients, 0.7% of male outpatients, 0.2% of female employees, and 0.4% of male employees) and in six siblings of these participants.	Iron	15-19	transferrin	Homo sapiens	39-50
9559866-9	1998	These results demonstrate that iron overload significantly alters the expression of antioxidant enzymes associated with glutathione (GGT and GST) and superoxide metabolism (CuZnSOD and MnSOD).	Iron	31-35	superoxide dismutase 1	Rattus norvegicus	173-180
9461487-0	1998	Mutagenesis of the aspartic acid ligands in human serum transferrin: lobe-lobe interaction and conformation as revealed by antibody, receptor-binding and iron-release studies.	Iron	154-158	transferrin	Homo sapiens	56-67
9600219-0	1998	Abnormal iron deposition associated with lipid peroxidation in transgenic mice expressing interleukin-6 in the brain.	Iron	9-13	interleukin 6	Mus musculus	90-103
9600219-2	1998	Based on ultrastructural observations showing electron-dense pigment in the brain of the GFAP-IL6 mice, we hypothesized that iron metabolism was altered in the brains of these animals.	Iron	125-129	interleukin 6	Mus musculus	94-97
9600219-9	1998	These results suggest that the IL6-induced BBB defect precipitates iron accumulation in the GFAP-IL6 mouse brain and that subsequent IBP regulation mediates protective responses.	Iron	67-71	interleukin 6	Mus musculus	31-34
9600219-9	1998	These results suggest that the IL6-induced BBB defect precipitates iron accumulation in the GFAP-IL6 mouse brain and that subsequent IBP regulation mediates protective responses.	Iron	67-71	interleukin 6	Mus musculus	97-100
9600219-11	1998	This transgenic mouse model of IL6-mediated neurodegeneration provides a unique opportunity to examine several aspects of iron metabolism in the brain, including its entry at the site of the BBB, its distribution through the IBP, and its mechanisms of toxicity.	Iron	122-126	interleukin 6	Mus musculus	31-34
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Iron	31-35	matrix metallopeptidase 3	Homo sapiens	189-202
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Iron	31-35	matrix metallopeptidase 3	Homo sapiens	204-209
9478985-6	1998	The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed.	Iron	4-8	mitogen-activated protein kinase 9	Homo sapiens	189-193
9478985-6	1998	The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed.	Iron	4-8	matrix metallopeptidase 3	Homo sapiens	292-297
9482759-1	1998	Iron regulatory protein 1 (IRP1) and IRP2 are cytoplasmic RNA binding proteins that are central regulators of mammalian iron homeostasis.	Iron	120-124	iron responsive element binding protein 2	Homo sapiens	37-41
9521555-3	1998	We have demonstrated that iron controls hemoglobin (Hb) synthesis in erythroid differentiating K562 cells by enhancing the activity of a key enzyme of the Hb synthesis, delta-aminolevulinate synthase (ALAS).	Iron	26-30	5'-aminolevulinate synthase 1	Homo sapiens	169-199
9521555-3	1998	We have demonstrated that iron controls hemoglobin (Hb) synthesis in erythroid differentiating K562 cells by enhancing the activity of a key enzyme of the Hb synthesis, delta-aminolevulinate synthase (ALAS).	Iron	26-30	5'-aminolevulinate synthase 1	Homo sapiens	201-205
9452506-0	1998	Iron differentially stimulates translation of mitochondrial aconitase and ferritin mRNAs in mammalian cells.	Iron	0-4	aconitase 2	Homo sapiens	46-69
9484220-0	1998	Iron regulatory element and internal loop/bulge structure for ferritin mRNA studied by cobalt(III) hexammine binding, molecular modeling, and NMR spectroscopy.	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	94-97
9448300-0	1998	Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.	Iron	93-97	solute carrier family 11 member 2	Rattus norvegicus	0-6
9448300-0	1998	Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.	Iron	93-97	solute carrier family 11 member 2	Rattus norvegicus	73-79
9448300-2	1998	The b reticulocyte defect appears to be failure of iron transport out of endosomes within the transferrin cycle.	Iron	51-55	transferrin	Rattus norvegicus	94-105
9448300-10	1998	Functional studies of the protein encoded by the b allele of rat Nramp2 demonstrated that the mutation disrupted iron transport.	Iron	113-117	solute carrier family 11 member 2	Rattus norvegicus	65-71
9448300-12	1998	Furthermore, the phenotypic characteristics of these animals indicate that Nramp2 is essential both for normal intestinal iron absorption and for transport of iron out of the transferrin cycle endosome.	Iron	122-126	solute carrier family 11 member 2	Rattus norvegicus	75-81
9448300-12	1998	Furthermore, the phenotypic characteristics of these animals indicate that Nramp2 is essential both for normal intestinal iron absorption and for transport of iron out of the transferrin cycle endosome.	Iron	159-163	solute carrier family 11 member 2	Rattus norvegicus	75-81
9448300-12	1998	Furthermore, the phenotypic characteristics of these animals indicate that Nramp2 is essential both for normal intestinal iron absorption and for transport of iron out of the transferrin cycle endosome.	Iron	159-163	transferrin	Rattus norvegicus	175-186
9452506-4	1998	First, we demonstrate that m-Acon synthesis is iron-regulated in mammalian cells.	Iron	47-51	aconitase 2	Homo sapiens	27-33
9452506-5	1998	In HL-60 cells, hemin (an iron source) stimulated m-Acon synthesis 3-fold after 4 h compared with cells treated with an iron chelator (Desferal).	Iron	26-30	aconitase 2	Homo sapiens	50-56
9452506-7	1998	Second, we show that iron modulates the polysomal association of m-Acon mRNA.	Iron	21-25	aconitase 2	Homo sapiens	65-71
9452506-10	1998	Third, our results indicate that iron differentially regulates translation of m-Acon and ferritin mRNAs.	Iron	33-37	aconitase 2	Homo sapiens	78-84
9452506-12	1998	We conclude that iron modulates m-Acon synthesis at the translational level and that iron regulatory proteins appear to differentially affect translation of IRE-containing mRNAs.	Iron	17-21	aconitase 2	Homo sapiens	32-38
9498807-0	1998	[1H,13C] NMR determination of the order of lobe loading of human transferrin with iron: comparison with other metal ions.	Iron	82-86	transferrin	Homo sapiens	65-76
9528678-0	1998	Specific binding to plasma membrane is the first step in the uptake of non-transferrin iron by cultured cells.	Iron	87-91	transferrin	Homo sapiens	75-86
9543094-1	1998	Excess iron has been postulated as a risk factor for coronary artery disease (CAD) because of its presence in atherosclerotic lesions, its ability to oxidize low density lipoprotein cholesterol (LDLc), and its promotion of oxygen reperfusion damage after an ischemic event.	Iron	7-11	component of oligomeric golgi complex 2	Homo sapiens	195-199
9528678-1	1998	We studied transport of non-transferrin iron into HeLa cells adapted for growth in defined medium, containing either 5 micrograms/ml of iron-saturated transferrin (HeLa/Tf cells) or 5 microM ferric citrate (HeLa/Fe5 cells) as a source of iron.	Iron	136-140	transferrin	Homo sapiens	151-162
9528678-1	1998	We studied transport of non-transferrin iron into HeLa cells adapted for growth in defined medium, containing either 5 micrograms/ml of iron-saturated transferrin (HeLa/Tf cells) or 5 microM ferric citrate (HeLa/Fe5 cells) as a source of iron.	Iron	136-140	transferrin	Homo sapiens	151-162
9528678-8	1998	The uptake of non-transferrin iron is realized in at least two steps.	Iron	30-34	transferrin	Homo sapiens	18-29
9531972-1	1998	Transferrin (Tf) is required for proliferation of most cells, because cellular iron uptake is mainly mediated by binding of Tf to its specific cell surface receptors (TfR).	Iron	79-83	transferrin	Homo sapiens	0-11
9531972-1	1998	Transferrin (Tf) is required for proliferation of most cells, because cellular iron uptake is mainly mediated by binding of Tf to its specific cell surface receptors (TfR).	Iron	79-83	transferrin	Homo sapiens	13-15
9531972-1	1998	Transferrin (Tf) is required for proliferation of most cells, because cellular iron uptake is mainly mediated by binding of Tf to its specific cell surface receptors (TfR).	Iron	79-83	transferrin	Homo sapiens	124-126
9466567-1	1998	Transferrin (Tf), a major transport protein for iron in the blood and an essential growth factor in some tissues, acts via specific transferrin receptor (TfR).	Iron	48-52	transferrin	Homo sapiens	0-11
9466567-1	1998	Transferrin (Tf), a major transport protein for iron in the blood and an essential growth factor in some tissues, acts via specific transferrin receptor (TfR).	Iron	48-52	transferrin	Homo sapiens	13-15
9466567-6	1998	In pituitaries with iron deposits, Tf and TfR were localized only in iron-free cells.	Iron	69-73	transferrin	Homo sapiens	35-37
9446669-2	1998	In the present study, we showed that stimulation of murine macrophage J774 cells with interferon (IFN)-gamma/lipopolysaccharide (LPS) resulted in a nitric oxide-dependent modulation of the activity of iron regulatory proteins (IRP)-1 and 2, cytoplasmic proteins which, binding to RNA motifs called iron responsive elements (IRE), control ferritin translation.	Iron	201-205	interferon gamma	Mus musculus	86-108
9446669-2	1998	In the present study, we showed that stimulation of murine macrophage J774 cells with interferon (IFN)-gamma/lipopolysaccharide (LPS) resulted in a nitric oxide-dependent modulation of the activity of iron regulatory proteins (IRP)-1 and 2, cytoplasmic proteins which, binding to RNA motifs called iron responsive elements (IRE), control ferritin translation.	Iron	298-302	interferon gamma	Mus musculus	86-108
9446671-1	1998	Iron overload in Africa was previously regarded as purely due to excessive iron in traditional beer, but we recently found evidence that transferrin saturation and unsaturated iron binding capacity may be influenced by an interaction between dietary iron content and a gene distinct from any HLA-linked locus.	Iron	0-4	transferrin	Homo sapiens	137-148
9469497-0	1998	Total iron-binding capacity-estimated transferrin correlates with the nutritional subjective global assessment in hemodialysis patients.	Iron	6-10	transferrin	Homo sapiens	38-49
9446671-3	1998	Iron status was characterized with repeated morning measurements of serum ferritin, transferrin saturation, and unsaturated iron binding capacity after supplementation with vitamin C.	Iron	0-4	transferrin	Homo sapiens	84-95
9450593-6	1998	In addition, the water plant"s radium laden iron filters contributed 7 Bq L-1 and 60 Bq L-1 of 222Rn to the finished water in What Cheer, Iowa, and Wellman, Iowa, respectively.	Iron	44-48	L1 cell adhesion molecule	Homo sapiens	74-100
9548292-1	1998	Further studies on chiral resolution of drugs with different chemical structures by capillary zone electrophoresis using iron-free human serum transferrin are described.	Iron	121-125	transferrin	Homo sapiens	143-154
28081424-0	1998	Measurements of Trace Metal (Fe, Cu, Mn, Cr) Oxidation States in Fog and Stratus Clouds.	Iron	29-31	zinc finger protein, FOG family member 1	Homo sapiens	65-68
9513812-4	1998	Antioxydant enzymes (SOD, catalase), the iron chelators (desferrioxamine, transferrin) and the free radical scavengers (uric acid, carnosine) inhibited the degradation by Maillard products confirming its free radical nature and the intervention of trace metals.	Iron	41-45	transferrin	Homo sapiens	74-85
9480790-1	1998	As an adaptation to the iron-restricted environment of the host, some bacterial pathogens possess iron acquisition pathways mediated by surface receptors that specifically bind transferrin from the host.	Iron	24-28	transferrin	Homo sapiens	177-188
9756115-0	1998	Effective utilization of erythropoietin with intravenous iron therapy.	Iron	57-61	erythropoietin	Homo sapiens	25-39
9756115-1	1998	INTRODUCTION: Iron replacement therapy reduces the demand for erythropoietin (EPO) in some dialysis patients.	Iron	14-18	erythropoietin	Homo sapiens	62-76
9756115-1	1998	INTRODUCTION: Iron replacement therapy reduces the demand for erythropoietin (EPO) in some dialysis patients.	Iron	14-18	erythropoietin	Homo sapiens	78-81
9756115-2	1998	It has been postulated that iron supply to the bone marrow is a rate-limiting step in the process of erythropoiesis under erythropoietin stimulation.	Iron	28-32	erythropoietin	Homo sapiens	122-136
9756115-12	1998	CONCLUSION: Intravenous iron therapy is a safe and cost-effective method for maintaining or improving Hb levels with a more effective utilization of EPO in patients with low SF levels despite oral iron therapy.	Iron	24-28	erythropoietin	Homo sapiens	149-152
9756115-12	1998	CONCLUSION: Intravenous iron therapy is a safe and cost-effective method for maintaining or improving Hb levels with a more effective utilization of EPO in patients with low SF levels despite oral iron therapy.	Iron	197-201	erythropoietin	Homo sapiens	149-152
9512304-7	1998	Because iron is involved in the syntheses and functions of dopamine, serotonin, and gamma-aminobutyric acid (GABA), transferrin may be carried for various iron uses from an early fetal stage.	Iron	8-12	transferrin	Homo sapiens	116-127
9512304-7	1998	Because iron is involved in the syntheses and functions of dopamine, serotonin, and gamma-aminobutyric acid (GABA), transferrin may be carried for various iron uses from an early fetal stage.	Iron	155-159	transferrin	Homo sapiens	116-127
9489672-2	1998	Neisseria gonorrhoeae, the causative agent of gonorrhoea, can acquire iron by direct interaction with human iron-binding proteins, including the serum glycoprotein, transferrin.	Iron	70-74	transferrin	Homo sapiens	165-176
9489672-2	1998	Neisseria gonorrhoeae, the causative agent of gonorrhoea, can acquire iron by direct interaction with human iron-binding proteins, including the serum glycoprotein, transferrin.	Iron	108-112	transferrin	Homo sapiens	165-176
9480790-1	1998	As an adaptation to the iron-restricted environment of the host, some bacterial pathogens possess iron acquisition pathways mediated by surface receptors that specifically bind transferrin from the host.	Iron	43-47	transferrin	Homo sapiens	177-188
9489672-3	1998	Iron internalization from host transferrin requires the expression of a bacterial receptor, which specifically recognizes the human form of transferrin.	Iron	0-4	transferrin	Homo sapiens	31-42
9489672-3	1998	Iron internalization from host transferrin requires the expression of a bacterial receptor, which specifically recognizes the human form of transferrin.	Iron	0-4	transferrin	Homo sapiens	140-151
9430733-1	1998	Iron regulatory proteins 1 and 2 (IRP-1, IRP-2) interact with iron-responsive elements (IREs) present in the 5"- or 3"-untranslated regions (UTR) of several mRNAs coding for proteins in iron metabolism.	Iron	62-66	iron responsive element binding protein 2	Homo sapiens	41-46
9559558-4	1998	The HCR2 protein was detected in the membrane fractions of cells grown under conditions which would favor the induction of HCR2-mRNA and the protein level was lowered when the cells were transferred from iron deficient to 10 microM FeSO4 conditions (with 20% CO2).	Iron	204-208	dicarbonyl and L-xylulose reductase	Homo sapiens	4-8
9430733-5	1998	Cells cultured in iron-rich or -depleted medium were labeled with [35S]methionine, and secreted growth hormone was immunoprecipitated.	Iron	18-22	growth hormone 1	Homo sapiens	96-110
9430733-1	1998	Iron regulatory proteins 1 and 2 (IRP-1, IRP-2) interact with iron-responsive elements (IREs) present in the 5"- or 3"-untranslated regions (UTR) of several mRNAs coding for proteins in iron metabolism.	Iron	186-190	iron responsive element binding protein 2	Homo sapiens	41-46
9458819-3	1998	NO synthase (NOS) activity was also induced by iron treatment (16.2 +/- 2.0 vs. 0.4 +/- 0.2 nmol of [3H]citrulline/mg protein, P &lt; 0.01).	Iron	47-51	nitric oxide synthase 2	Homo sapiens	0-11
10649730-1	1998	In recombinant human erythropoietin (rHuEpo)-treated anemic peritoneal dialysis (PD) patients, oral iron therapy, despite its limited efficacy, remains an accepted and convenient method of iron supplementation.	Iron	100-104	erythropoietin	Homo sapiens	21-35
10649730-1	1998	In recombinant human erythropoietin (rHuEpo)-treated anemic peritoneal dialysis (PD) patients, oral iron therapy, despite its limited efficacy, remains an accepted and convenient method of iron supplementation.	Iron	189-193	erythropoietin	Homo sapiens	21-35
9458819-6	1998	Superoxide dismutase and catalase decreased iron-induced MDA production but did not affect LDH leakage or NO production.	Iron	44-48	catalase	Homo sapiens	25-33
9481432-0	1998	Recombinant human erythropoietin resistance in iron-replete hemodialysis patients: role of aluminum toxicity.	Iron	47-51	erythropoietin	Homo sapiens	18-32
18370466-0	1998	Erythropoietin effectiveness index : a quantitative definition of resistance in haemodialysis patients with adequate iron stores.	Iron	117-121	erythropoietin	Homo sapiens	0-14
9624256-8	1998	Ferric ions were confirmed as potentiators of the growth inhibitory effect of LiGLA but more physiologically relevant transferrin-bound iron was ineffective.	Iron	136-140	transferrin	Homo sapiens	118-129
9550556-0	1998	Serum transferrin receptors are decreased in the presence of iron overload.	Iron	61-65	transferrin	Homo sapiens	6-17
9550556-1	1998	To test the hypothesis that the quantities of circulating transferrin receptors are reduced in iron overload, we studied serum transferrin receptors and indirect measures of iron status in 150 subjects from rural Zimbabwe.	Iron	95-99	transferrin	Homo sapiens	58-69
9550556-1	1998	To test the hypothesis that the quantities of circulating transferrin receptors are reduced in iron overload, we studied serum transferrin receptors and indirect measures of iron status in 150 subjects from rural Zimbabwe.	Iron	174-178	transferrin	Homo sapiens	58-69
9550556-3	1998	The mean +/- SD concentration of serum transferrin receptors in 23 subjects classified as having iron overload (ferritin &gt; 300 microg/L and transferrin saturation &gt; 60%) was 1.55 +/- 0.61 mg/L, significantly lower than the 2.50 +/- 0.62 mg/L in 75 subjects with normal iron stores (ferritin 20-300 microg/L and transferrin saturation 15-55%; P &lt; 0.0005) and the 2.83 +/- 1.14 mg/L in 8 subjects with iron deficiency (ferritin &lt; 20 microg/L; P = 0.001).	Iron	97-101	transferrin	Homo sapiens	39-50
9550556-3	1998	The mean +/- SD concentration of serum transferrin receptors in 23 subjects classified as having iron overload (ferritin &gt; 300 microg/L and transferrin saturation &gt; 60%) was 1.55 +/- 0.61 mg/L, significantly lower than the 2.50 +/- 0.62 mg/L in 75 subjects with normal iron stores (ferritin 20-300 microg/L and transferrin saturation 15-55%; P &lt; 0.0005) and the 2.83 +/- 1.14 mg/L in 8 subjects with iron deficiency (ferritin &lt; 20 microg/L; P = 0.001).	Iron	275-279	transferrin	Homo sapiens	39-50
9550556-4	1998	In keeping with the regulation of transferrin receptor expression at the cellular level, our findings suggest that serum transferrin receptors are decreased in the presence of iron overload.	Iron	176-180	transferrin	Homo sapiens	34-45
9550556-4	1998	In keeping with the regulation of transferrin receptor expression at the cellular level, our findings suggest that serum transferrin receptors are decreased in the presence of iron overload.	Iron	176-180	transferrin	Homo sapiens	121-132
9491286-0	1998	Comparative response to single or divided doses of parenteral iron for functional iron deficiency in hemodialysis patients receiving erythropoietin (EPO).	Iron	62-66	erythropoietin	Homo sapiens	133-147
9491286-0	1998	Comparative response to single or divided doses of parenteral iron for functional iron deficiency in hemodialysis patients receiving erythropoietin (EPO).	Iron	62-66	erythropoietin	Homo sapiens	149-152
9491286-1	1998	EPO treatment rapidly corrects anemia in patients with end-stage renal failure treated with hemodialysis, as long as sufficient iron is available.	Iron	128-132	erythropoietin	Homo sapiens	0-3
9491286-2	1998	Absolute and relative (to demand) iron deficiency blunts the erythropoietic response and parenteral iron is frequently required during the course of therapy to restore EPO efficacy.	Iron	100-104	erythropoietin	Homo sapiens	168-171
10730863-0	1998	Transferrin receptor expression is controlled differently by transferrin-bound and non-transferrin iron in human cells.	Iron	99-103	transferrin	Homo sapiens	87-98
10730863-2	1998	Defined conditions of iron supply were represented by (i) 5 microg/ml of iron-saturated transferrin (transferrin medium) and by (ii) 500 microM ferric citrate (ferric citrate medium).	Iron	73-77	transferrin	Homo sapiens	88-99
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	16-20	transferrin	Homo sapiens	37-48
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	16-20	transferrin	Homo sapiens	119-130
9443932-0	1998	Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism.	Iron	20-24	aryl-hydrocarbon receptor	Mus musculus	105-108
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	16-20	transferrin	Homo sapiens	119-130
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	49-53	transferrin	Homo sapiens	119-130
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	49-53	transferrin	Homo sapiens	119-130
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	49-53	transferrin	Homo sapiens	119-130
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	49-53	transferrin	Homo sapiens	119-130
27416284-2	1998	However due to an increase in demand, a functional iron deficiency state may arise which is characterised by an inability to supply iron and subsequent EPO resistance.	Iron	51-55	erythropoietin	Homo sapiens	152-155
9504407-0	1998	Aluminum taken up by transferrin-independent iron uptake affects the iron metabolism in rat cortical cells.	Iron	69-73	transferrin	Rattus norvegicus	21-32
9504407-1	1998	We previously demonstrated that cultured human fibroblasts internalize iron via transferrin-independent iron uptake (Tf-IU), redox, and receptor-mediated endocytosis uptake systems [Oshiro, S., Nakajima, H., Markello, T., Krasnewich, D., Bernardini, I., and Gahl, W.A.	Iron	71-75	transferrin	Homo sapiens	80-91
9504407-1	1998	We previously demonstrated that cultured human fibroblasts internalize iron via transferrin-independent iron uptake (Tf-IU), redox, and receptor-mediated endocytosis uptake systems [Oshiro, S., Nakajima, H., Markello, T., Krasnewich, D., Bernardini, I., and Gahl, W.A.	Iron	104-108	transferrin	Homo sapiens	80-91
27416284-16	1998	These results suggest that RCFer and CHr may help detect the onset of functional iron deficiency in patients commencing EPO therapy despite oral iron.	Iron	81-85	erythropoietin	Homo sapiens	120-123
27416284-17	1998	EPO therapy leads to a significant depletion of both erythroid and storage iron.	Iron	75-79	erythropoietin	Homo sapiens	0-3
9469483-7	1998	Reduced transferrin receptor internalization may limit lymphocyte expansion by depleting the intracellular iron stores needed for cellular function and proliferation.	Iron	107-111	transferrin	Rattus norvegicus	8-19
9771919-1	1998	Iron Regulatory Proteins (IRPs), by modulating expression of ferritin, which stores excess iron in a non toxic form, and transferrin receptor, which controls iron uptake, are the main controller of cellular iron metabolism.	Iron	158-162	transferrin	Homo sapiens	121-132
9771919-1	1998	Iron Regulatory Proteins (IRPs), by modulating expression of ferritin, which stores excess iron in a non toxic form, and transferrin receptor, which controls iron uptake, are the main controller of cellular iron metabolism.	Iron	158-162	transferrin	Homo sapiens	121-132
9613713-11	1998	However, the previously described association between animal fat intake and PD was modified by iron level stores as measured by transferrin saturation.	Iron	95-99	transferrin	Homo sapiens	128-139
9481720-0	1998	Iron absorption in erythropoietin-treated haemodialysis patients: effects of iron availability, inflammation and aluminium.	Iron	0-4	erythropoietin	Homo sapiens	19-33
9481720-1	1998	BACKGROUND: The response to recombinant human erythropoietin (rHuEpo) is determined primarily by the availability of iron.	Iron	117-121	erythropoietin	Homo sapiens	46-60
10388095-27	1998	STRUCTURE OF AROMATASE REVEALS SECRETS OF SELECTIVE INHIBITION: Aromatase is a cytochrome P450 enzyme, with both an iron-containing and a steroid-binding site.	Iron	116-120	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	13-22
9481720-9	1998	Dialysis patients with high C-reactive protein (CRP) values showed lower iron absorption.	Iron	73-77	C-reactive protein	Homo sapiens	28-46
9481720-9	1998	Dialysis patients with high C-reactive protein (CRP) values showed lower iron absorption.	Iron	73-77	C-reactive protein	Homo sapiens	48-51
9481720-10	1998	Iron absorption data correlated significantly with transferrin saturation and CRP in the iron-deficient group, and with serum ferritin in the iron-replete group.	Iron	0-4	transferrin	Homo sapiens	51-62
9481720-10	1998	Iron absorption data correlated significantly with transferrin saturation and CRP in the iron-deficient group, and with serum ferritin in the iron-replete group.	Iron	0-4	C-reactive protein	Homo sapiens	78-81
10388095-27	1998	STRUCTURE OF AROMATASE REVEALS SECRETS OF SELECTIVE INHIBITION: Aromatase is a cytochrome P450 enzyme, with both an iron-containing and a steroid-binding site.	Iron	116-120	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	64-73
10388095-29	1998	From this structural relationship, there are, therefore, two reasonable ways to inhibit aromatase: * by occupying the steroid-binding site of the enzyme with a compound such as formestane (Lentaron&amp;reg;), or * by binding the iron with nitrogen-containing compounds such as aminoglutethimide (Orimeten&amp;reg;), the oldest aromatase inhibitor.	Iron	229-233	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	88-97
9460808-13	1998	These proteins "sense" levels of iron in the transit pool and, when iron in this pool is scarce, they bind to stem-loop structures known as iron-responsive elements on the 5" untranslated region of the ferritin mRNA and 3" untranslated region of the transferrin mRNA.	Iron	68-72	transferrin	Homo sapiens	250-261
9492551-0	1998	[Increased erythron transferrin uptake associated with ineffective erythropoiesis in iron deficiency state--the common factors to iron deficiency anemia and portal hypertensions].	Iron	85-89	transferrin	Homo sapiens	20-31
9509508-1	1998	The aim of this study was to investigate the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in children with iron deficiency anemia before and after iron supplementation.	Iron	124-128	interleukin 2	Homo sapiens	61-74
9509508-1	1998	The aim of this study was to investigate the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in children with iron deficiency anemia before and after iron supplementation.	Iron	124-128	interleukin 2	Homo sapiens	76-80
9509508-1	1998	The aim of this study was to investigate the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in children with iron deficiency anemia before and after iron supplementation.	Iron	124-128	interleukin 6	Homo sapiens	86-99
9509508-1	1998	The aim of this study was to investigate the serum levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in children with iron deficiency anemia before and after iron supplementation.	Iron	124-128	interleukin 6	Homo sapiens	101-105
9509508-4	1998	In the iron-deficiency group the production of IL-2 was found to be significantly lower than that in controls and became normal after iron supplementation (P &lt; .001).	Iron	7-11	interleukin 2	Homo sapiens	47-51
9509508-4	1998	In the iron-deficiency group the production of IL-2 was found to be significantly lower than that in controls and became normal after iron supplementation (P &lt; .001).	Iron	134-138	interleukin 2	Homo sapiens	47-51
9460806-7	1998	We postulate that the basolateral membranes of absorptive cells possess both holo-transferrin and apotransferrin receptors that regulate the ingress and egress of cellular iron, respectively.	Iron	172-176	transferrin	Homo sapiens	82-93
9460806-8	1998	Unlike absorptive cells, nonintestinal cells appear to possess three pathways for uptake of inorganic iron: (1) the classical transferrin-transferrin receptor pathway, (2) the transferrin-associated transferrin receptor independent pathway (TRIP), and (3) the transferrin-independent mobilferrin-integrin pathway (MIP) observed in intestinal absorptive cells.	Iron	102-106	transferrin	Homo sapiens	126-137
9460806-8	1998	Unlike absorptive cells, nonintestinal cells appear to possess three pathways for uptake of inorganic iron: (1) the classical transferrin-transferrin receptor pathway, (2) the transferrin-associated transferrin receptor independent pathway (TRIP), and (3) the transferrin-independent mobilferrin-integrin pathway (MIP) observed in intestinal absorptive cells.	Iron	102-106	transferrin	Homo sapiens	138-149
9460811-4	1998	Genetic defects of proteins essential for transport of iron into and out of cells (transferrin and ceruloplasmin) deprive the erythron of the metal and cause its accumulation in other vital organs.	Iron	55-59	transferrin	Homo sapiens	83-94
9460806-8	1998	Unlike absorptive cells, nonintestinal cells appear to possess three pathways for uptake of inorganic iron: (1) the classical transferrin-transferrin receptor pathway, (2) the transferrin-associated transferrin receptor independent pathway (TRIP), and (3) the transferrin-independent mobilferrin-integrin pathway (MIP) observed in intestinal absorptive cells.	Iron	102-106	transferrin	Homo sapiens	138-149
9460806-8	1998	Unlike absorptive cells, nonintestinal cells appear to possess three pathways for uptake of inorganic iron: (1) the classical transferrin-transferrin receptor pathway, (2) the transferrin-associated transferrin receptor independent pathway (TRIP), and (3) the transferrin-independent mobilferrin-integrin pathway (MIP) observed in intestinal absorptive cells.	Iron	102-106	transferrin	Homo sapiens	138-149
9460806-8	1998	Unlike absorptive cells, nonintestinal cells appear to possess three pathways for uptake of inorganic iron: (1) the classical transferrin-transferrin receptor pathway, (2) the transferrin-associated transferrin receptor independent pathway (TRIP), and (3) the transferrin-independent mobilferrin-integrin pathway (MIP) observed in intestinal absorptive cells.	Iron	102-106	transferrin	Homo sapiens	138-149
9460806-9	1998	The TRIP is used when transferrin receptors become saturated at physiological concentrations of iron and transferrin.	Iron	96-100	transferrin	Homo sapiens	22-33
9460806-11	1998	Alternatively, it may facilitate iron uptake from the TRIP after degradation of transferrin near the surface of the cell.	Iron	33-37	transferrin	Homo sapiens	80-91
9460806-12	1998	However, both transferrin-associated pathways donate iron to a common intracellular iron pathway for ferri-reduction and probably other functions.	Iron	53-57	transferrin	Homo sapiens	14-25
9460806-12	1998	However, both transferrin-associated pathways donate iron to a common intracellular iron pathway for ferri-reduction and probably other functions.	Iron	84-88	transferrin	Homo sapiens	14-25
9460808-3	1998	Physiologically, the majority of cells in the organism acquire iron from a well-characterized plasma glycoprotein, transferrin.	Iron	63-67	transferrin	Homo sapiens	115-126
9460808-4	1998	Iron uptake from transferrin is reasonably well understood, and involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis, and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	17-28
9460808-4	1998	Iron uptake from transferrin is reasonably well understood, and involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis, and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	88-99
9460808-4	1998	Iron uptake from transferrin is reasonably well understood, and involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis, and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	88-99
9460808-4	1998	Iron uptake from transferrin is reasonably well understood, and involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis, and the release of iron from the protein by a decrease in endosomal pH.	Iron	0-4	transferrin	Homo sapiens	88-99
9460808-4	1998	Iron uptake from transferrin is reasonably well understood, and involves the binding of transferrin to the transferrin receptor, internalization of transferrin within an endocytic vesicle by receptor-mediated endocytosis, and the release of iron from the protein by a decrease in endosomal pH.	Iron	241-245	transferrin	Homo sapiens	17-28
9784666-1	1998	BACKGROUND AND OBJECTIVES: The clinical importance of iron-restricted erythropoiesis in erythropoietin (EPO)-stimulated patients is controversial.	Iron	54-58	erythropoietin	Homo sapiens	88-102
9460808-5	1998	Most of the transferrin-bound iron is used for the synthesis of hemoglobin by developing erythroid cells.	Iron	30-34	transferrin	Homo sapiens	12-23
9460808-13	1998	These proteins "sense" levels of iron in the transit pool and, when iron in this pool is scarce, they bind to stem-loop structures known as iron-responsive elements on the 5" untranslated region of the ferritin mRNA and 3" untranslated region of the transferrin mRNA.	Iron	33-37	transferrin	Homo sapiens	250-261
9460808-13	1998	These proteins "sense" levels of iron in the transit pool and, when iron in this pool is scarce, they bind to stem-loop structures known as iron-responsive elements on the 5" untranslated region of the ferritin mRNA and 3" untranslated region of the transferrin mRNA.	Iron	68-72	transferrin	Homo sapiens	250-261
9784666-4	1998	EPO-treated iron-depleted patients produced 20% less RBC than iron-replete patients (8.23+/-3.3 vs. 10.	Iron	12-16	erythropoietin	Homo sapiens	0-3
9784666-1	1998	BACKGROUND AND OBJECTIVES: The clinical importance of iron-restricted erythropoiesis in erythropoietin (EPO)-stimulated patients is controversial.	Iron	54-58	erythropoietin	Homo sapiens	104-107
9784666-6	1998	RBC volume expansion correlated with initial storage iron only in iron-replete patients who received EPO therapy.	Iron	66-70	erythropoietin	Homo sapiens	101-104
9392457-4	1997	Iron overload decreased both, catalase and Mn-superoxide dismutase activities by 49 and 54%, respectively, with no effect on glutathione peroxidase activity.	Iron	0-4	catalase	Rattus norvegicus	30-38
9784666-7	1998	CONCLUSION: Initial storage iron status is a marginally important limitation to EPO-mediated erythropoiesis in the setting of oral iron supplementation.	Iron	28-32	erythropoietin	Homo sapiens	80-83
9784666-8	1998	Strategies to maintain plasma transferrin saturation with intravenous iron therapy may be desirable to improve the erythropoietic response to EPO in this setting.	Iron	70-74	erythropoietin	Homo sapiens	142-145
9398231-10	1997	A mechanism is proposed to explain demetallation of heme, involving attack on the tetrapyrrole nitrogens of the protoporphyrin IX-Fe by protons derived from protein carboxylic acid groups and subsequent complexation of the iron by the corresponding carboxylates and binding of protoporphyrin IX to a preformed pocket in the inner surface of the apoferritin protein shell.	Iron	130-132	ferritin heavy chain	Equus caballus	345-356
9461300-5	1997	The regulation of transferrin receptor and ferritin in response to iron perturbations has been studied extensively and is mediated by the binding of iron-regulatory proteins (IRP) to the iron-responsive elements (IRE) present in the 3" and 5" untranslated regions of the transferrin-receptor and ferritin mRNA, respectively.	Iron	67-71	transferrin	Homo sapiens	18-29
9461300-5	1997	The regulation of transferrin receptor and ferritin in response to iron perturbations has been studied extensively and is mediated by the binding of iron-regulatory proteins (IRP) to the iron-responsive elements (IRE) present in the 3" and 5" untranslated regions of the transferrin-receptor and ferritin mRNA, respectively.	Iron	67-71	transferrin	Homo sapiens	271-282
9461300-5	1997	The regulation of transferrin receptor and ferritin in response to iron perturbations has been studied extensively and is mediated by the binding of iron-regulatory proteins (IRP) to the iron-responsive elements (IRE) present in the 3" and 5" untranslated regions of the transferrin-receptor and ferritin mRNA, respectively.	Iron	149-153	transferrin	Homo sapiens	18-29
9461300-5	1997	The regulation of transferrin receptor and ferritin in response to iron perturbations has been studied extensively and is mediated by the binding of iron-regulatory proteins (IRP) to the iron-responsive elements (IRE) present in the 3" and 5" untranslated regions of the transferrin-receptor and ferritin mRNA, respectively.	Iron	149-153	transferrin	Homo sapiens	271-282
9398231-9	1997	(v) When around 20 atoms of iron/molecule are incorporated into horse spleen apoferritin and protoporphyrin IX is then bound, iron can subsequently be transferred to the porphyrin at pH 8.0.	Iron	28-32	ferritin heavy chain	Equus caballus	77-88
9398231-9	1997	(v) When around 20 atoms of iron/molecule are incorporated into horse spleen apoferritin and protoporphyrin IX is then bound, iron can subsequently be transferred to the porphyrin at pH 8.0.	Iron	126-130	ferritin heavy chain	Equus caballus	77-88
9396727-2	1997	This protein is sensitive to intracellular iron availability, being activated at low iron levels and inactivated at high iron levels, conditions that signal the increased expression of the transferrin receptor or of ferritin respectively.	Iron	43-47	transferrin	Homo sapiens	189-200
9396727-2	1997	This protein is sensitive to intracellular iron availability, being activated at low iron levels and inactivated at high iron levels, conditions that signal the increased expression of the transferrin receptor or of ferritin respectively.	Iron	85-89	transferrin	Homo sapiens	189-200
9396727-2	1997	This protein is sensitive to intracellular iron availability, being activated at low iron levels and inactivated at high iron levels, conditions that signal the increased expression of the transferrin receptor or of ferritin respectively.	Iron	85-89	transferrin	Homo sapiens	189-200
9398231-10	1997	A mechanism is proposed to explain demetallation of heme, involving attack on the tetrapyrrole nitrogens of the protoporphyrin IX-Fe by protons derived from protein carboxylic acid groups and subsequent complexation of the iron by the corresponding carboxylates and binding of protoporphyrin IX to a preformed pocket in the inner surface of the apoferritin protein shell.	Iron	223-227	ferritin heavy chain	Equus caballus	345-356
9357020-0	1997	Iron-induced inhibition of Na+, K(+)-ATPase and Na+/Ca2+ exchanger in synaptosomes: protection by the pyridoindole stobadine.	Iron	0-4	solute carrier family 8 member A1	Homo sapiens	48-66
9429666-11	1997	Thus, acidosis is known to enhance iron-catalysed production of reactive oxygen species, probably by releasing iron from its bindings to transferrin, ferritin and other proteins.	Iron	35-39	transferrin	Homo sapiens	137-148
9429666-11	1997	Thus, acidosis is known to enhance iron-catalysed production of reactive oxygen species, probably by releasing iron from its bindings to transferrin, ferritin and other proteins.	Iron	111-115	transferrin	Homo sapiens	137-148
9439462-0	1997	The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum.	Iron	47-51	transferrin	Homo sapiens	113-124
9439463-2	1997	After saturation of serum transferrin with an excess amount of iron (first step), the unbound iron was eliminated by formation of a complex with ferrozine, which was used as a chromogenic reagent (second step).	Iron	63-67	transferrin	Homo sapiens	26-37
9439463-2	1997	After saturation of serum transferrin with an excess amount of iron (first step), the unbound iron was eliminated by formation of a complex with ferrozine, which was used as a chromogenic reagent (second step).	Iron	94-98	transferrin	Homo sapiens	26-37
9439463-4	1997	Because the iron used as a calibrator, which was added to saturate transferrin, reacted completely with ferrozine in the second step (elimination of unbound iron), the change in the absorbance to generate a calibration factor could not be monitored in the third step.	Iron	12-16	transferrin	Homo sapiens	67-78
9439463-5	1997	To solve this problem, we used N-(2-hydroxyethyl)ethylenediamine-N,N",N"-triacetic acid (HEDTA) to complex with the iron added to saturate transferrin in the second step.	Iron	116-120	transferrin	Homo sapiens	139-150
9504894-4	1997	As an example, the uptake of transferrin-bound iron by enterocytes was studied.	Iron	47-51	transferrin	Rattus norvegicus	29-40
9504894-12	1997	Uptake of transferrin-bound iron into enterocytes was highest with feeding an iron-loaded diet compared with control or iron-deficient diets.	Iron	28-32	transferrin	Rattus norvegicus	10-21
9504894-12	1997	Uptake of transferrin-bound iron into enterocytes was highest with feeding an iron-loaded diet compared with control or iron-deficient diets.	Iron	78-82	transferrin	Rattus norvegicus	10-21
9504894-12	1997	Uptake of transferrin-bound iron into enterocytes was highest with feeding an iron-loaded diet compared with control or iron-deficient diets.	Iron	78-82	transferrin	Rattus norvegicus	10-21
9364049-5	1997	In "chambered" sympathetic neurons in culture, 125I-Tf or iron as 55Fe-Tf added to the cell body/dendrite chamber is recovered in the axonal chamber, showing that internalized ligand from the cell body-dendrite area is released at the axonal end.	Iron	58-62	transferrin	Homo sapiens	71-73
9430909-1	1997	iron saccharate in haemodialysis patients not responding to oral iron and erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	74-88
9398207-1	1997	Human serum transferrin N-lobe (hTF/2N) has four iron-binding ligands, including one histidine, one aspartate, and two tyrosines.	Iron	49-53	transferrin	Homo sapiens	12-23
9398126-1	1997	Intravenous (IV) iron therapy can reduce erythropoietin (EPO) requirements in dialysis patients.	Iron	17-21	erythropoietin	Homo sapiens	41-55
9398126-1	1997	Intravenous (IV) iron therapy can reduce erythropoietin (EPO) requirements in dialysis patients.	Iron	17-21	erythropoietin	Homo sapiens	57-60
9398141-14	1997	Patients who were iron deficient by standard measures (serum ferritin &lt; 100 ng/mL or transferrin saturation less than 20%) had a greater and a sustained CHr response to intravenous iron dextran.	Iron	18-22	transferrin	Homo sapiens	88-99
9371699-0	1997	Iron release from recombinant N-lobe and single point Asp63 mutants of human transferrin by EDTA.	Iron	0-4	transferrin	Homo sapiens	77-88
9371699-3	1997	Iron release from the unmutated N-lobe of human serum transferrin (hTF/2N) by EDTA is influenced by a variety of factors.	Iron	0-4	transferrin	Homo sapiens	54-65
9406656-2	1997	Proximal tubular cell dysfunction in chronic glomerular disease (CGD) has been ascribed, in part, to reabsorption of transferrin-iron from tubular fluid and subsequent cytosolic peroxidative injury.	Iron	129-133	transferrin	Rattus norvegicus	117-128
9402955-1	1997	Transferrin (Tf), an iron-transporting protein, has many variants, but C1 and C2 variants account for the majority of the population in all races.	Iron	21-25	transferrin	Homo sapiens	0-11
9451192-3	1997	Recent studies into the safety and efficacy of recombinant human erythropoietin in infants with AOP have demonstrated consistently a rise in hematocrits and reticulocyte counts, fewer blood transfusions, reduced transfused volume of blood per kilogram body weight, and a decrease in bioavailable iron.	Iron	296-300	erythropoietin	Homo sapiens	65-79
9371823-6	1997	In the studies presented here, we demonstrate by immunohistochemistry that the HFE protein is expressed in human placenta in the apical plasma membrane of the syncytiotrophoblasts, where the transferrin-bound iron is normally transported to the fetus via receptor-mediated endocytosis.	Iron	209-213	transferrin	Homo sapiens	191-202
9389898-10	1997	High transferrin saturation and lack of differences in plasma Fe between the groups are probably due to Fe released from lysed erythrocytes.	Iron	104-106	transferrin	Homo sapiens	5-16
9428655-1	1997	The iron-superoxide dismutase in the thermoacidophilic archaeon Sulfolobus solfataricus has a homodimeric structure with a metal content of 0.7 atom of iron per subunit.	Iron	4-8	shikimate dehydrogenase	Saccharolobus solfataricus	9-29
9396915-10	1997	The negative correlation of erythropoietin concentration with posthemorrhagic red blood cell mass suggests that iron, not erythropoietin, may be the limiting factor in recovery from hemorrhage-induced anemia.	Iron	112-116	erythropoietin	Homo sapiens	28-42
9374731-6	1997	Moreover, chelation of surface iron from crocidolite fibers or addition of N-acetyl-L-cysteine prevented ERK activation and apoptosis by crocidolite, indicating an oxidative mechanism of cell signaling.	Iron	31-35	Eph receptor B1	Rattus norvegicus	105-108
9385449-1	1997	According to spectral data the midtransition temperature of the cleavage of the sulfur-iron bond was 57.4 +/- 0.5 degrees C and 66.8 +/- 0.5 degrees C for cytochrome c and cytochrome c-polyglutamate complex, respectively.	Iron	87-91	cytochrome c, somatic	Homo sapiens	155-167
9385449-1	1997	According to spectral data the midtransition temperature of the cleavage of the sulfur-iron bond was 57.4 +/- 0.5 degrees C and 66.8 +/- 0.5 degrees C for cytochrome c and cytochrome c-polyglutamate complex, respectively.	Iron	87-91	cytochrome c, somatic	Homo sapiens	172-184
9486090-2	1997	The extracellular proteins caeruloplasmin and transferrin have important antioxidant properties by virtue of the fact that they inhibit iron-dependent free radical production, and ensuing damage to cells.	Iron	136-140	transferrin	Rattus norvegicus	46-57
9432136-8	1997	Since transferrin secreted by Sertoli cells is an important molecule in maintaining the crucial iron level necessary for spermatogenesis, the identification of haptoglobin as a Sertoli and germ cell product adds a new member to the growing family of metal transporters in the testis that are likely to play an important role in iron metabolism in the testis.	Iron	96-100	transferrin	Rattus norvegicus	6-17
9432136-8	1997	Since transferrin secreted by Sertoli cells is an important molecule in maintaining the crucial iron level necessary for spermatogenesis, the identification of haptoglobin as a Sertoli and germ cell product adds a new member to the growing family of metal transporters in the testis that are likely to play an important role in iron metabolism in the testis.	Iron	96-100	haptoglobin	Rattus norvegicus	160-171
9432136-8	1997	Since transferrin secreted by Sertoli cells is an important molecule in maintaining the crucial iron level necessary for spermatogenesis, the identification of haptoglobin as a Sertoli and germ cell product adds a new member to the growing family of metal transporters in the testis that are likely to play an important role in iron metabolism in the testis.	Iron	328-332	haptoglobin	Rattus norvegicus	160-171
9375751-0	1997	Non-transferrin-bound iron induced by myeloablative chemotherapy.	Iron	22-26	transferrin	Homo sapiens	4-15
9375751-1	1997	Previous studies have suggested that non-transferrin-bound plasma iron (NTBI) is present in patients undergoing cytotoxic chemotherapy, and that this may exacerbate untoward organ damage and increase the risk of bacterial infections following chemotherapy.	Iron	66-70	transferrin	Homo sapiens	41-52
9421741-9	1997	#P6 was given intratumourally (1.5 x 10(-2) mg ferrite/mm3) 20-30 minutes before excitation and was combined with magnetic targeting (50 mT), which yielded a 2.5-fold enhancement of the intratumoural iron concentration.	Iron	200-204	S100 calcium binding protein A12	Homo sapiens	0-3
9360608-1	1997	The first crystal structure of the iron-transporter ferric ion-binding protein from Haemophilus influenzae (hFBP), at 1.6 A resolution, reveals the structural basis for iron uptake and transport required by several important bacterial pathogens.	Iron	35-39	ECB2	Homo sapiens	108-112
9383735-7	1997	The corrosion of stainless steel by chloride ions at the low pH of the formulation buffer generated iron ions that catalyzed methionine oxidation in rhuMAb HER2.	Iron	100-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	156-160
9413439-3	1997	To identify other yeast genes involved in iron uptake, we isolated genes that could, when overexpressed, suppress the iron-limited growth defect of a fet3 fet4 mutant.	Iron	42-46	Fet4p	Saccharomyces cerevisiae S288C	155-159
9413439-3	1997	To identify other yeast genes involved in iron uptake, we isolated genes that could, when overexpressed, suppress the iron-limited growth defect of a fet3 fet4 mutant.	Iron	118-122	Fet4p	Saccharomyces cerevisiae S288C	155-159
9440316-1	1997	Under excitation by visible light the iron storage protein ferritin catalyses the reduction of cytochrome c and viologens as well as the oxidation of carboxylic acids, thiol compounds, and sulfite.	Iron	38-42	cytochrome c, somatic	Homo sapiens	95-107
9360608-2	1997	Paradoxically, although hFBP belongs to a protein superfamily which includes human transferrin, iron binding in hFBP and transferrin appears to have developed independently by convergent evolution.	Iron	96-100	ECB2	Homo sapiens	24-28
9360608-2	1997	Paradoxically, although hFBP belongs to a protein superfamily which includes human transferrin, iron binding in hFBP and transferrin appears to have developed independently by convergent evolution.	Iron	96-100	ECB2	Homo sapiens	112-116
9360608-2	1997	Paradoxically, although hFBP belongs to a protein superfamily which includes human transferrin, iron binding in hFBP and transferrin appears to have developed independently by convergent evolution.	Iron	96-100	transferrin	Homo sapiens	121-132
9360608-4	1997	The iron binding site of hFBP incorporates a water and an exogenous phosphate ion as iron ligands and exhibits nearly ideal octahedral metal coordination.	Iron	4-8	ECB2	Homo sapiens	25-29
9360608-4	1997	The iron binding site of hFBP incorporates a water and an exogenous phosphate ion as iron ligands and exhibits nearly ideal octahedral metal coordination.	Iron	85-89	ECB2	Homo sapiens	25-29
9360608-5	1997	FBP is highly conserved, required for virulence, and is a nodal point for free iron uptake in several Gram-negative pathogenic bacteria, thus providing a potential target for broad-spectrum antibacterial drug design against human pathogens such as H. influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis.	Iron	79-83	ECB2	Homo sapiens	0-3
9353884-2	1997	Transferrin and transferrin receptors play an important role in the transport of iron into the brain.	Iron	81-85	transferrin	Rattus norvegicus	0-11
9415934-9	1997	It has previously been proposed that oral iron provides adequate supplementation during increased demand caused by EPO stimulation.	Iron	42-46	erythropoietin	Homo sapiens	115-118
9415935-25	1997	Both TS and SF are non-specific and insensitive indicators for accurate diagnosis of iron deficiency in hemodialysis patients in EPO.	Iron	85-89	erythropoietin	Homo sapiens	129-132
9328369-8	1997	In a long-term study over 5 months in patients on a stable maintenance dose of EPO, a gradual decline in total body iron occurred, even in subjects with initial adequate iron stores, and despite taking 50 mg elemental iron daily as oral ferrous sulphate.	Iron	116-120	erythropoietin	Homo sapiens	79-82
9328369-8	1997	In a long-term study over 5 months in patients on a stable maintenance dose of EPO, a gradual decline in total body iron occurred, even in subjects with initial adequate iron stores, and despite taking 50 mg elemental iron daily as oral ferrous sulphate.	Iron	170-174	erythropoietin	Homo sapiens	79-82
9328369-8	1997	In a long-term study over 5 months in patients on a stable maintenance dose of EPO, a gradual decline in total body iron occurred, even in subjects with initial adequate iron stores, and despite taking 50 mg elemental iron daily as oral ferrous sulphate.	Iron	170-174	erythropoietin	Homo sapiens	79-82
9357851-4	1997	Treatment with the antioxidant 1,3-dimethyl-2-thiourea (10 mM) or the iron chelator deferoxamine (1.8 microM) doubles basal ET-1 release.	Iron	70-74	endothelin 1	Rattus norvegicus	124-128
10084945-7	1997	Both Pasteurella multocida and Pasteurella haemolytica strains utilize iron from porcine and bovine transferrin, but not from haemin and haemoglobin.	Iron	71-75	serotransferrin	Bos taurus	100-111
9353879-2	1997	In the alkaline region, the CD profiles of iron(III) and cobalt(III) transferrin are essentially pH independent up to pH 11; only for very high pH values (pH &gt; 11) is breakdown of the cobalt(III) and iron(III) transferrin derivatives observed, without evidence of conformational rearrangements.	Iron	43-47	transferrin	Homo sapiens	213-224
9353879-10	1997	The pH dependent properties of iron(III), cobalt(III) and copper(II) transferrin are discussed in the frame of the present knowledge of transferrin chemistry, particular emphasis being attributed to the comparison between tripositive and bipositive metal derivatives.	Iron	31-35	transferrin	Homo sapiens	69-80
9353879-10	1997	The pH dependent properties of iron(III), cobalt(III) and copper(II) transferrin are discussed in the frame of the present knowledge of transferrin chemistry, particular emphasis being attributed to the comparison between tripositive and bipositive metal derivatives.	Iron	31-35	transferrin	Homo sapiens	136-147
9384338-3	1997	To evaluate the effect of iron overload in response to high dose IFN-alpha in young chronic hepatitis C virus thalassemia patients.	Iron	26-30	interferon alpha 1	Homo sapiens	65-68
9325328-10	1997	This suggested that pyrrolidine dithiocarbamate was inhibiting NF-kappaB activation in endothelial cells primarily through its iron-chelating properties.	Iron	127-131	nuclear factor kappa B subunit 1	Homo sapiens	63-72
9325328-16	1997	Furthermore, tumor necrosis factor and interleukin-1 activate NF-kappaB through different mechanisms in ECV304 cells, with the tumor necrosis factor pathway involving iron-catalyzed lipid peroxidation.	Iron	167-171	tumor necrosis factor	Homo sapiens	13-34
9325328-16	1997	Furthermore, tumor necrosis factor and interleukin-1 activate NF-kappaB through different mechanisms in ECV304 cells, with the tumor necrosis factor pathway involving iron-catalyzed lipid peroxidation.	Iron	167-171	nuclear factor kappa B subunit 1	Homo sapiens	62-71
9325328-16	1997	Furthermore, tumor necrosis factor and interleukin-1 activate NF-kappaB through different mechanisms in ECV304 cells, with the tumor necrosis factor pathway involving iron-catalyzed lipid peroxidation.	Iron	167-171	tumor necrosis factor	Homo sapiens	127-148
9322572-1	1997	Chromium competes with iron for binding to transferrin, and high-dose chromium supplementation has been hypothesized to adversely affect iron status.	Iron	23-27	transferrin	Homo sapiens	43-54
9367796-3	1997	Moreover, the presence of exogenous antioxidant systems, such as superoxide dismutase, catalase, vitamin E, dimethylsulfoxide, and desferroxamine, an iron chelating agent, resulted in significant protection from ADM-mediated damage.	Iron	150-154	catalase	Homo sapiens	87-95
9353884-2	1997	Transferrin and transferrin receptors play an important role in the transport of iron into the brain.	Iron	81-85	transferrin	Rattus norvegicus	16-27
9356804-4	1997	Iron-binding proteins such as transferrin, ferritin, and lactoferrin have a central role in human ferrokinetics.	Iron	0-4	transferrin	Homo sapiens	30-41
9335289-1	1997	Transferrin-binding protein B (TbpB) from Neisseria meningitidis binds human transferrin (hTf) at the surface of the bacterial cell as part of the iron uptake process.	Iron	147-151	transferrin	Homo sapiens	77-88
9352960-4	1997	Adequate intravenous iron supplementation allows reduction of epoetin dosage by approximately 40%.	Iron	21-25	erythropoietin	Homo sapiens	62-69
9352960-6	1997	During the maintenance phase (period of epoetin therapy after correction of iron deficiency), the use of low-dose intravenous iron supplementation (10 to 20 mg per haemodialysis treatment or 100 mg every second week) avoids iron overtreatment and minimises potential adverse effects.	Iron	126-130	erythropoietin	Homo sapiens	40-47
9352960-7	1997	Depending on the degree of pre-existing iron deficiency, markedly higher iron doses are necessary during the correction phase (period of epoetin therapy after correction of iron deficiency) [e.g. intravenous iron 40 to 100 mg per haemodialysis session up to a total dose of 1000 mg].	Iron	73-77	erythropoietin	Homo sapiens	137-144
9365067-15	1997	CONCLUSION: Reduced GH secretion and low IGF-I in thalassaemic patients are related to a neurosecretory dysfunction due to iron overload rather than to liver damage.	Iron	123-127	insulin like growth factor 1	Homo sapiens	41-46
9365048-0	1997	Unidirectional upregulation of the synthesis of the major iron proteins, transferrin-receptor and ferritin, in HepG2 cells by the acute-phase protein alpha1-antitrypsin.	Iron	58-62	serpin family A member 1	Homo sapiens	150-168
9365048-1	1997	BACKGROUND/AIMS: We have previously shown that the hepatic acute-phase protein alpha1-antitrypsin (alpha1-AT) is an important mediator of changes in iron metabolism in the course of anaemia of chronic disease.	Iron	149-153	serpin family A member 1	Homo sapiens	79-97
9365048-1	1997	BACKGROUND/AIMS: We have previously shown that the hepatic acute-phase protein alpha1-antitrypsin (alpha1-AT) is an important mediator of changes in iron metabolism in the course of anaemia of chronic disease.	Iron	149-153	serpin family A member 1	Homo sapiens	99-108
9365048-2	1997	Alpha1-AT profoundly reduces growth of erythroid cells by interfering with transferrin-mediated iron uptake.	Iron	96-100	serpin family A member 1	Homo sapiens	0-9
9365048-2	1997	Alpha1-AT profoundly reduces growth of erythroid cells by interfering with transferrin-mediated iron uptake.	Iron	96-100	transferrin	Homo sapiens	75-86
9365048-3	1997	In the present work we investigate the effects of alpha1-AT on hepatic iron metabolism, as the liver plays a central role in body iron metabolism and in metabolic changes during acute-phase response.	Iron	71-75	serpin family A member 1	Homo sapiens	50-59
9365048-9	1997	In addition, alpha1-AT caused a distinct increase in iron regulatory protein binding activity to iron responsive elements, which is characteristic of iron deprivation.	Iron	53-57	serpin family A member 1	Homo sapiens	13-22
9335326-7	1997	Conversely, the intracellular iron chelator, desferrioxamine, stimulated TNF-alpha expression.	Iron	30-34	tumor necrosis factor	Homo sapiens	73-82
9365048-9	1997	In addition, alpha1-AT caused a distinct increase in iron regulatory protein binding activity to iron responsive elements, which is characteristic of iron deprivation.	Iron	97-101	serpin family A member 1	Homo sapiens	13-22
9335326-8	1997	Thus, the expression of TNF-alpha, itself a physiological regulator of iron homeostasis, appears to be controlled by intracellular levels of iron.	Iron	71-75	tumor necrosis factor	Homo sapiens	24-33
9335326-0	1997	Suppression of TNF-alpha gene expression by hemin: implications for the role of iron homeostasis in host inflammatory responses.	Iron	80-84	tumor necrosis factor	Homo sapiens	15-24
9335326-1	1997	Tumor necrosis factor alpha (TNF-alpha) has multiple effects on iron homeostasis and erythropoiesis and has been implicated in the pathogenesis of the anemia of inflammation.	Iron	64-68	tumor necrosis factor	Homo sapiens	0-27
9335326-8	1997	Thus, the expression of TNF-alpha, itself a physiological regulator of iron homeostasis, appears to be controlled by intracellular levels of iron.	Iron	141-145	tumor necrosis factor	Homo sapiens	24-33
9335326-1	1997	Tumor necrosis factor alpha (TNF-alpha) has multiple effects on iron homeostasis and erythropoiesis and has been implicated in the pathogenesis of the anemia of inflammation.	Iron	64-68	tumor necrosis factor	Homo sapiens	29-38
9335326-2	1997	We postulated that intracellular iron in turn may regulate the expression of TNF-alpha.	Iron	33-37	tumor necrosis factor	Homo sapiens	77-86
9335326-6	1997	Sn-protoporphyrin, an inhibitor of heme oxygenase (which releases iron from hemin), prevented hemin-induced suppression of TNF-alpha expression.	Iron	66-70	tumor necrosis factor	Homo sapiens	123-132
9365048-9	1997	In addition, alpha1-AT caused a distinct increase in iron regulatory protein binding activity to iron responsive elements, which is characteristic of iron deprivation.	Iron	97-101	serpin family A member 1	Homo sapiens	13-22
9365048-12	1997	CONCLUSIONS: The effect of alpha1-AT on transferrin receptor synthesis appears to be mediated via activation of iron responsive element binding affinity of iron regulatory protein leading to an increased stability of transferrin receptor mRNA.	Iron	112-116	serpin family A member 1	Homo sapiens	27-36
9365048-12	1997	CONCLUSIONS: The effect of alpha1-AT on transferrin receptor synthesis appears to be mediated via activation of iron responsive element binding affinity of iron regulatory protein leading to an increased stability of transferrin receptor mRNA.	Iron	112-116	transferrin	Homo sapiens	40-51
9365048-12	1997	CONCLUSIONS: The effect of alpha1-AT on transferrin receptor synthesis appears to be mediated via activation of iron responsive element binding affinity of iron regulatory protein leading to an increased stability of transferrin receptor mRNA.	Iron	112-116	transferrin	Homo sapiens	217-228
9365048-15	1997	Our results emphasize the central role of alpha1-AT as a mediator of altered iron metabolism, characteristic of anaemia of chronic disease, not only with respect to erythroid cells but also with respect to liver cells.	Iron	77-81	serpin family A member 1	Homo sapiens	42-51
9383187-2	1997	are capable of iron utilization from host iron-binding proteins including transferrin and lactoferrin.	Iron	15-19	transferrin	Homo sapiens	74-85
9383187-2	1997	are capable of iron utilization from host iron-binding proteins including transferrin and lactoferrin.	Iron	42-46	transferrin	Homo sapiens	74-85
9383187-3	1997	Transferrin iron utilization is an energy-dependent, receptor-mediated event in which two identified transferrin-binding proteins participate.	Iron	12-16	transferrin	Homo sapiens	0-11
9383187-3	1997	Transferrin iron utilization is an energy-dependent, receptor-mediated event in which two identified transferrin-binding proteins participate.	Iron	12-16	transferrin	Homo sapiens	101-112
9337622-14	1997	radical adducts, indicating the presence of free OH.. Production of DMPO-OH was partly inhibited by superoxide dismutase (SOD), catalase and desferrioxamine, suggesting that the iron-catalyzed decomposition of H2O2 was partly involved in the formation of one part of the observed OH..	Iron	178-182	catalase	Homo sapiens	128-136
11770580-0	1997	Intravenous iron therapy for severe pregnancy anemia with high erythropoietin levels.	Iron	12-16	erythropoietin	Homo sapiens	63-77
11770580-3	1997	After IV iron administration, erythropoietin rapidly decreased and hemoglobin increased to 8.1 g/dL in correlation with estriol elevation.	Iron	9-13	erythropoietin	Homo sapiens	30-44
11770580-6	1997	High erythropoietin levels predict a good response to iron and may obviate the need for blood transfusions and recombinant erythropoietin administration, at least until this therapy is tried.	Iron	54-58	erythropoietin	Homo sapiens	5-19
9284502-3	1997	For the determination of the iron stores, a computer program has been developed that takes into account the ferritin concentrations, hemoglobin, and saturation of transferrin.	Iron	29-33	transferrin	Homo sapiens	163-174
9424732-1	1997	BACKGROUND: The aim of this work was to assess the major iron metabolism values in patients infected by human immunodeficiency virus (HIV), and to evaluate the correlation between these data and the immunological status of the patients as expressed by CD4 lymphocyte count.	Iron	57-61	CD4 molecule	Homo sapiens	252-255
9754329-14	1997	Similar to other oxidant tumor promoters, iron overload enhanced cutaneous lipid peroxidation and xanthine oxidase activity and decreased catalase activity.	Iron	42-46	catalase	Mus musculus	138-146
9326491-14	1997	These results provide indications of the mechanism by which IRP-1 stabilizes the transferrin receptor mRNA under iron depletion conditions.	Iron	113-117	transferrin	Homo sapiens	81-92
9424732-6	1997	Serum iron values in HIV infected patients (82 +/- 40 micrograms/L) are significantly lower (p &lt; 0.02) than those of the control subjects (115 +/- 56 micrograms/ dL), decreasing in parallel with the number of CD4 lymphocytes.	Iron	6-10	CD4 molecule	Homo sapiens	212-215
9311786-5	1997	Concomitantly, a refolding of the cytochrome c domain takes place, resulting in an unexpected change of the c haem iron coordination from His 17/His 69 to Met106/His69.	Iron	115-119	cytochrome c, somatic	Homo sapiens	34-46
9380735-2	1997	Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis.	Iron	147-151	heme oxygenase 1	Mus musculus	43-59
9380735-2	1997	Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis.	Iron	147-151	heme oxygenase 1	Mus musculus	61-66
9380735-2	1997	Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis.	Iron	184-188	heme oxygenase 1	Mus musculus	43-59
9380735-2	1997	Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis.	Iron	184-188	heme oxygenase 1	Mus musculus	61-66
9380735-4	1997	Our results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.	Iron	95-99	heme oxygenase 1	Mus musculus	26-31
9380735-4	1997	Our results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.	Iron	166-170	heme oxygenase 1	Mus musculus	26-31
9317063-0	1997	Hepatic iron stainings in chronic hepatitis C patients with low HCV RNA levels: a predictive marker for IFN therapy.	Iron	8-12	interferon alpha 1	Homo sapiens	104-107
9283096-1	1997	Release of iron from transferrin, the iron-transporting protein of the circulation, is a concerted process involving remote amino acid residues as well as those at the two specific iron-binding sites of the protein.	Iron	11-15	transferrin	Homo sapiens	21-32
9283096-1	1997	Release of iron from transferrin, the iron-transporting protein of the circulation, is a concerted process involving remote amino acid residues as well as those at the two specific iron-binding sites of the protein.	Iron	38-42	transferrin	Homo sapiens	21-32
9283096-3	1997	We have therefore turned to site-directed mutagenesis to investigate the role of Lys 569 in the release process at pH 5.6, the pH of the endosome where iron is transferred from transferrin to the iron-dependent cell.	Iron	152-156	transferrin	Homo sapiens	177-188
9316467-5	1997	Transferrin receptor activity was determined by the uptake of intravenously injected transferrin-bound iron and was shown to increase with the level of iron loading.	Iron	103-107	transferrin	Rattus norvegicus	0-11
9316467-5	1997	Transferrin receptor activity was determined by the uptake of intravenously injected transferrin-bound iron and was shown to increase with the level of iron loading.	Iron	103-107	transferrin	Rattus norvegicus	85-96
9316467-5	1997	Transferrin receptor activity was determined by the uptake of intravenously injected transferrin-bound iron and was shown to increase with the level of iron loading.	Iron	152-156	transferrin	Rattus norvegicus	0-11
9316467-5	1997	Transferrin receptor activity was determined by the uptake of intravenously injected transferrin-bound iron and was shown to increase with the level of iron loading.	Iron	152-156	transferrin	Rattus norvegicus	85-96
9317063-2	1997	Besides the serum HCV RNA level or HCV genotype, hepatic iron concentrations are thought to be correlated with the subsequent response to IFN therapy.	Iron	57-61	interferon alpha 1	Homo sapiens	138-141
9317063-3	1997	Our objective in the present study was to evaluate serum iron, ferritin, and hepatic iron staining in patients with low HCV RNA levels, as predictive markers for IFN therapy.	Iron	57-61	interferon alpha 1	Homo sapiens	162-165
9317063-3	1997	Our objective in the present study was to evaluate serum iron, ferritin, and hepatic iron staining in patients with low HCV RNA levels, as predictive markers for IFN therapy.	Iron	85-89	interferon alpha 1	Homo sapiens	162-165
9303500-0	1997	Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound iron.	Iron	42-46	transferrin	Homo sapiens	24-35
9303500-0	1997	Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound iron.	Iron	95-99	transferrin	Homo sapiens	24-35
9303489-0	1997	Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis.	Iron	7-11	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	76-81
9303489-6	1997	In addition, TGF-beta1 colocalized with hepatic iron and MDA protein adducts in hepatocytes and sinusoidal cells of hepatic acinar zone 1 and normalized after iron removal.	Iron	48-52	transforming growth factor beta 1	Homo sapiens	13-22
9303500-1	1997	The liver acquires iron from transferrin by transferrin receptor-mediated (TR) and transferrin receptor-independent pathways (NTR) and from nontransferrin-bound iron (NTB-Fe).	Iron	19-23	transferrin	Homo sapiens	29-40
9303489-6	1997	In addition, TGF-beta1 colocalized with hepatic iron and MDA protein adducts in hepatocytes and sinusoidal cells of hepatic acinar zone 1 and normalized after iron removal.	Iron	159-163	transforming growth factor beta 1	Homo sapiens	13-22
9303489-7	1997	Our data suggest that iron overload increases both lipid peroxidation and TGF-beta1 expression, which together could promote hepatic injury and fibrogenesis.	Iron	22-26	transforming growth factor beta 1	Homo sapiens	74-83
9303500-1	1997	The liver acquires iron from transferrin by transferrin receptor-mediated (TR) and transferrin receptor-independent pathways (NTR) and from nontransferrin-bound iron (NTB-Fe).	Iron	19-23	transferrin	Homo sapiens	44-55
9303500-1	1997	The liver acquires iron from transferrin by transferrin receptor-mediated (TR) and transferrin receptor-independent pathways (NTR) and from nontransferrin-bound iron (NTB-Fe).	Iron	19-23	transferrin	Homo sapiens	44-55
9338146-5	1997	Furthermore, the intracellular iron level (4.64 nmol/10(6) cells) of HeLa cells grown in low-iron medium was much higher than iron levels (0.15 or 0.20 nmol/10(6) cells) of HeLa or K562 cells grown in transferrin medium.	Iron	31-35	transferrin	Homo sapiens	201-212
9303500-4	1997	This was to determine if the uptake of transferrin-bound iron (Tf-Fe) and NTB-Fe uptake is mediated by a common iron-carrier.	Iron	57-61	transferrin	Homo sapiens	39-50
9338146-8	1997	Addition of iron chelator deferoxamine (50 microM, i.e., about half-maximal growth-inhibitory dose) resulted in significantly increased activity of IRP also in HeLa and THP-1 cells.	Iron	12-16	GLI family zinc finger 2	Homo sapiens	169-174
9303500-4	1997	This was to determine if the uptake of transferrin-bound iron (Tf-Fe) and NTB-Fe uptake is mediated by a common iron-carrier.	Iron	112-116	transferrin	Homo sapiens	39-50
9303500-5	1997	Iron citrate inhibited the uptake of 59Fe-transferrin (2.5 micromol/L Fe) in a concentration-dependent manner with a maximum effect when the citrate-iron:Tf-Fe molar ratio was 10:1.	Iron	39-41	transferrin	Homo sapiens	42-53
9303500-5	1997	Iron citrate inhibited the uptake of 59Fe-transferrin (2.5 micromol/L Fe) in a concentration-dependent manner with a maximum effect when the citrate-iron:Tf-Fe molar ratio was 10:1.	Iron	149-153	transferrin	Homo sapiens	42-53
9341986-2	1997	We confirmed the observations of Zak and Aisen (Zak O, Aisen P. Biochem Biophys Acta 1985;1952:24-8) that thermolysin treatment of human transferrin produces half molecules that retain iron-binding capacity.	Iron	185-189	transferrin	Homo sapiens	137-148
9290151-9	1997	In these experiments, there was a close correspondence between the amount of iron accumulated by the embryo and visceral yolk sac in the final 24 h of a 51-h culture and the amount of transferrin converted into acid-soluble products in the same period.	Iron	77-81	transferrin	Rattus norvegicus	184-195
9364922-1	1997	Ferric-binding proteins (FbpA) have been implicated in the transferrin receptor-mediated iron acquisition pathways of Haemophilus influenzae and Neisseria spp.	Iron	89-93	transferrin	Homo sapiens	59-70
9364922-2	1997	These proteins are believed to function by shuttling iron from outer membrane transferrin receptors to a specific inner membrane permease complex.	Iron	53-57	transferrin	Homo sapiens	78-89
9364922-5	1997	It is demonstrated that this mutant is deficient in its ability to use human transferrin as a sole iron source, even though the strain is still competent for binding human transferrin.	Iron	99-103	transferrin	Homo sapiens	77-88
9290151-11	1997	The results indicate that transferrin delivers iron for incorporation into both the embryo and the visceral yolk sac, and are consistent with a mechanism involving receptor-mediated endocytosis of iron-laden transferrin by the cells of the visceral yolk sac.	Iron	47-51	transferrin	Rattus norvegicus	26-37
9290151-11	1997	The results indicate that transferrin delivers iron for incorporation into both the embryo and the visceral yolk sac, and are consistent with a mechanism involving receptor-mediated endocytosis of iron-laden transferrin by the cells of the visceral yolk sac.	Iron	197-201	transferrin	Rattus norvegicus	26-37
9290151-11	1997	The results indicate that transferrin delivers iron for incorporation into both the embryo and the visceral yolk sac, and are consistent with a mechanism involving receptor-mediated endocytosis of iron-laden transferrin by the cells of the visceral yolk sac.	Iron	197-201	transferrin	Rattus norvegicus	208-219
9290151-12	1997	The transferrin itself appears to be quantitatively degraded, following delivery of iron to the yolk sac cells, a result that differs from findings in other cell types, in which the protein is not degraded but returns to the plasma membrane to participate in further cycles of iron acquisition and delivery.	Iron	84-88	transferrin	Rattus norvegicus	4-15
9294864-6	1997	Among the L1/L3 substitutions Glu256/ Thr274, Tyr409/His429, and Ser747/Asp766 affect the salt bridges (L1: Glu256...His248 and Asp490...Arg707) that in L1 restrict the access to the iron site from two opposite directions.	Iron	183-187	seed linoleate 13S-lipoxygenase-1	Glycine max	10-15
9290151-12	1997	The transferrin itself appears to be quantitatively degraded, following delivery of iron to the yolk sac cells, a result that differs from findings in other cell types, in which the protein is not degraded but returns to the plasma membrane to participate in further cycles of iron acquisition and delivery.	Iron	277-281	transferrin	Rattus norvegicus	4-15
9254606-1	1997	The mechanism by which the iron-transport protein transferrin releases its iron in vivo is presently unclear.	Iron	27-31	transferrin	Homo sapiens	50-61
9250112-7	1997	Compared with the iron-depleted group, the iron-sufficient group had significantly higher hemoglobin, transferrin saturation, and serum ferritin values and a significantly greater tendency to use iron supplements.	Iron	43-47	transferrin	Homo sapiens	102-113
9337853-1	1997	The binding of iron by transferrin leads to a significant conformational change in each lobe of the protein.	Iron	15-19	transferrin	Homo sapiens	23-34
9337853-2	1997	Numerous studies have shown that the transferrin receptor discriminates between iron-saturated and iron-free transferrin and that it modulates the release of iron.	Iron	80-84	transferrin	Homo sapiens	37-48
9337853-2	1997	Numerous studies have shown that the transferrin receptor discriminates between iron-saturated and iron-free transferrin and that it modulates the release of iron.	Iron	80-84	transferrin	Homo sapiens	109-120
9337853-2	1997	Numerous studies have shown that the transferrin receptor discriminates between iron-saturated and iron-free transferrin and that it modulates the release of iron.	Iron	99-103	transferrin	Homo sapiens	109-120
9337853-2	1997	Numerous studies have shown that the transferrin receptor discriminates between iron-saturated and iron-free transferrin and that it modulates the release of iron.	Iron	99-103	transferrin	Homo sapiens	37-48
9337853-2	1997	Numerous studies have shown that the transferrin receptor discriminates between iron-saturated and iron-free transferrin and that it modulates the release of iron.	Iron	99-103	transferrin	Homo sapiens	109-120
9337853-13	1997	Each lobe is able to donate iron to transferrin receptors on HeLa S3 cells in the presence of the contralateral lobe.	Iron	28-32	transferrin	Homo sapiens	36-47
9268159-2	1997	In the present study, we examined the effects of established and novel compounds including antioxidants, ribonucleotide reductase inhibitors, and iron chelators on NF-kappaB activation and HIV LTR-mediated gene expression induced by TNF-alpha.	Iron	146-150	tumor necrosis factor	Homo sapiens	233-242
9268159-6	1997	On the other hand, iron chelators desferrioxamine, pyridoxal isonicotinoyl hydrazone (PIH), and salicylaldehyde isonicotinoyl hydrazone (SIH) showed no inhibition of TNF-alpha-induced NF-kappaB DNA-binding activity.	Iron	19-23	tumor necrosis factor	Homo sapiens	166-175
9337853-2	1997	Numerous studies have shown that the transferrin receptor discriminates between iron-saturated and iron-free transferrin and that it modulates the release of iron.	Iron	99-103	transferrin	Homo sapiens	37-48
9242665-1	1997	Expression of several proteins of higher eukaryotes is post-transcriptionally regulated by interaction of iron-responsive elements (IREs) on their mRNAs and iron regulatory proteins (IRP1 and IRP2).	Iron	106-110	iron responsive element binding protein 2	Homo sapiens	192-196
9242665-4	1997	IRP2 is also regulated by intracellular iron level, but it is assumed that regulation is achieved by accelerated turn-over.	Iron	40-44	iron responsive element binding protein 2	Homo sapiens	0-4
9260793-10	1997	The relationship between liver iron and response to IFN treatment requires further prospective investigations.	Iron	31-35	interferon alpha 1	Homo sapiens	52-55
9250112-7	1997	Compared with the iron-depleted group, the iron-sufficient group had significantly higher hemoglobin, transferrin saturation, and serum ferritin values and a significantly greater tendency to use iron supplements.	Iron	43-47	transferrin	Homo sapiens	102-113
9326511-0	1997	Serum Transferrin Receptor Levels in Different Stages of Iron Deficiency	Iron	57-61	transferrin	Homo sapiens	6-17
9266922-0	1997	The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin.	Iron	26-30	erythropoietin	Homo sapiens	81-95
9377472-3	1997	Certain human pathogens take up iron from human transferrin, lactoferrin, hemoglobin, and heme.	Iron	32-36	transferrin	Homo sapiens	48-59
9265905-5	1997	Increased serum transferrin saturation is currently the best test for detection of those likely to accumulate iron.	Iron	110-114	transferrin	Homo sapiens	16-27
9235943-1	1997	Previous studies have demonstrated that diferric transferrin and apotransferrin compete for the binding to basolateral transferrin receptors and that transferrin-mediated iron uptake by Caco-2 cells is inhibited by apotransferrin to a larger extent than that predicted solely by receptor competition.	Iron	171-175	transferrin	Homo sapiens	49-60
9277046-0	1997	Serum erythropoietin during normal pregnancy: relationship to hemoglobin and iron status markers and impact of iron supplementation in a longitudinal, placebo-controlled study on 118 women.	Iron	77-81	erythropoietin	Homo sapiens	6-20
9277046-4	1997	In the iron-treated women, median serum EPO rose from 23.9 to 29.9 U/l (P = 0.0001).	Iron	7-11	erythropoietin	Homo sapiens	40-43
9277046-5	1997	Serum EPO showed a steeper increase in the placebo-treated women than in the iron-treated women (P &lt; 0.05).	Iron	77-81	erythropoietin	Homo sapiens	6-9
9277046-8	1997	In the placebo-treated women there was a negative correlation and in the iron-treated women a positive correlation between serum EPO and Hb.	Iron	73-77	erythropoietin	Homo sapiens	129-132
9277046-9	1997	In the placebo-treated women, inverse correlations existed between serum EPO and serum transferrin saturation and serum ferritin, reflecting the consequences of iron deficiency, whereas the iron-treated women displayed no correlation.	Iron	161-165	erythropoietin	Homo sapiens	73-76
9277046-11	1997	In placebo-treated women, iron deficient erythropoiesis constitutes an additional hypoxic stimulus, which induces a further increase in serum EPO.	Iron	26-30	erythropoietin	Homo sapiens	142-145
9292281-11	1997	5 As the plasma transferrin concentration did not change over the experimental period, the concentration of absorbed iron in the mesenteric plasma exceeded the iron-binding capacity of plasma transferrin at low blood flow rates.	Iron	117-121	transferrin	Rattus norvegicus	16-27
9292281-11	1997	5 As the plasma transferrin concentration did not change over the experimental period, the concentration of absorbed iron in the mesenteric plasma exceeded the iron-binding capacity of plasma transferrin at low blood flow rates.	Iron	160-164	transferrin	Rattus norvegicus	192-203
9235943-6	1997	Moreover, the intracellular distribution of transferrin receptors was influenced by the iron load of transferrin; cells incubated with apotransferrin presented a more apical distribution of transferrin receptors than cells incubated with diferric transferrin.	Iron	88-92	transferrin	Homo sapiens	44-55
9235943-6	1997	Moreover, the intracellular distribution of transferrin receptors was influenced by the iron load of transferrin; cells incubated with apotransferrin presented a more apical distribution of transferrin receptors than cells incubated with diferric transferrin.	Iron	88-92	transferrin	Homo sapiens	101-112
9235943-6	1997	Moreover, the intracellular distribution of transferrin receptors was influenced by the iron load of transferrin; cells incubated with apotransferrin presented a more apical distribution of transferrin receptors than cells incubated with diferric transferrin.	Iron	88-92	transferrin	Homo sapiens	101-112
9235943-6	1997	Moreover, the intracellular distribution of transferrin receptors was influenced by the iron load of transferrin; cells incubated with apotransferrin presented a more apical distribution of transferrin receptors than cells incubated with diferric transferrin.	Iron	88-92	transferrin	Homo sapiens	101-112
9235943-7	1997	These results indicate for the first time that the endocytic cycle of transferrin receptors in intestinal epithelial cells is determined by the iron content of transferrin.	Iron	144-148	transferrin	Homo sapiens	70-81
9235943-7	1997	These results indicate for the first time that the endocytic cycle of transferrin receptors in intestinal epithelial cells is determined by the iron content of transferrin.	Iron	144-148	transferrin	Homo sapiens	160-171
9235943-8	1997	They explain also the marked inhibitory effect of apotransferrin on transferrin-mediated iron uptake by Caco-2 cells, since incubation of cells with apotransferrin resulted in the actual sequestration of the receptor in the cell interior.	Iron	89-93	transferrin	Homo sapiens	53-64
9278862-2	1997	Because these cells have no direct access to systemic iron, there exists a shuttle system involving production and secretion of the iron-transporting protein transferrin by the Sertoli cells.	Iron	54-58	transferrin	Rattus norvegicus	158-169
9231702-6	1997	Iron crosses the luminal membrane of the capillary endothelium by receptor-mediated endocytosis of ferric transferrin.	Iron	0-4	transferrin	Rattus norvegicus	106-117
9231702-7	1997	This results in an initial linear uptake of radioactive iron into brain at an average rate relative to serum of about 3.3 x 10(-3) ml x g of brain(-1) x h(-1) in the adult rat.	Iron	56-60	POU class 3 homeobox 3	Rattus norvegicus	141-149
9231702-15	1997	Within interstitial fluid, transported iron will bind with any unsaturated transferrin synthesized or transported into the brain-CSF system.	Iron	39-43	transferrin	Rattus norvegicus	75-86
9245601-0	1997	Tertiary structural changes and iron release from human serum transferrin.	Iron	32-36	transferrin	Homo sapiens	62-73
9245601-1	1997	Iron release from human serum transferrin was investigated by comparison of the extent of bound iron, measured by charge transfer absorption band intensity (465 nm), with changes observed by small-angle solution X-ray scattering (SAXS) for a series of equilibrated samples between pH 5.69 and 7.77.	Iron	0-4	transferrin	Homo sapiens	30-41
9245601-1	1997	Iron release from human serum transferrin was investigated by comparison of the extent of bound iron, measured by charge transfer absorption band intensity (465 nm), with changes observed by small-angle solution X-ray scattering (SAXS) for a series of equilibrated samples between pH 5.69 and 7.77.	Iron	96-100	transferrin	Homo sapiens	30-41
9278862-2	1997	Because these cells have no direct access to systemic iron, there exists a shuttle system involving production and secretion of the iron-transporting protein transferrin by the Sertoli cells.	Iron	132-136	transferrin	Rattus norvegicus	158-169
9441903-5	1997	A protective effect comparable to SIN-1 was observed when preincubating the cells with iron-free apoferritin (1 mg/ml).	Iron	87-91	MAPK associated protein 1	Homo sapiens	34-39
9245618-0	1997	Sequence analysis of the structural tbpA gene: protein topology and variable regions within neisserial receptors for transferrin iron acquisition.	Iron	129-133	transferrin	Homo sapiens	117-128
9249006-1	1997	Cytochrome P-450 2E1 (CYP2E1) is characterized by a rapid turnover in the liver and some cell lines and the ability of substrates and heme iron ligands to inhibit significantly enzyme degradation.	Iron	139-143	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	0-20
9280872-5	1997	One of the most important preconditions for successful recombinant human erythropoietin therapy is adequate iron supplementation.	Iron	108-112	erythropoietin	Homo sapiens	73-87
9247149-0	1997	Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells.	Iron	57-61	transferrin	Homo sapiens	15-26
9247149-1	1997	The rate of iron release from HepG2 liver cells was increased not only by extracellular apotransferrin, but also by diferric transferrin, in a non-additive, concentration-dependent manner and to a similar magnitude.	Iron	12-16	transferrin	Homo sapiens	91-102
11669965-11	1997	Iron(III) and manganese(III) porphyrins were relatively easy to reduce and readily underwent the reductive nitrosylation reaction, while cobalt(II) and chromium(III) porphyrins are unreactive.	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	5-8
11669965-11	1997	Iron(III) and manganese(III) porphyrins were relatively easy to reduce and readily underwent the reductive nitrosylation reaction, while cobalt(II) and chromium(III) porphyrins are unreactive.	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	24-27
11669965-11	1997	Iron(III) and manganese(III) porphyrins were relatively easy to reduce and readily underwent the reductive nitrosylation reaction, while cobalt(II) and chromium(III) porphyrins are unreactive.	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	24-27
9247771-3	1997	To ensure that full benefit from erythropoietin therapy is received, most patients require iron supplement during treatment.	Iron	91-95	erythropoietin	Homo sapiens	33-47
9247776-0	1997	An evaluation of the effectiveness of oral iron therapy in hemodialysis patients receiving recombinant human erythropoietin.	Iron	43-47	erythropoietin	Homo sapiens	109-123
9247776-1	1997	Iron balance is critical for adequate erythropoiesis in hemodialysis patients treated with recombinant human erythropoietin (EPO).	Iron	0-4	erythropoietin	Homo sapiens	109-123
9247776-1	1997	Iron balance is critical for adequate erythropoiesis in hemodialysis patients treated with recombinant human erythropoietin (EPO).	Iron	0-4	erythropoietin	Homo sapiens	125-128
9247787-0	1997	Maintenance therapy with intravenous iron in hemodialysis patients receiving erythropoietin.	Iron	37-41	erythropoietin	Homo sapiens	77-91
9249006-1	1997	Cytochrome P-450 2E1 (CYP2E1) is characterized by a rapid turnover in the liver and some cell lines and the ability of substrates and heme iron ligands to inhibit significantly enzyme degradation.	Iron	139-143	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	22-28
9199450-6	1997	In addition, norepinephrine stimulated the growth-promoting effect induced by human transferrin in iron-limited medium.	Iron	99-103	transferrin	Homo sapiens	84-95
9221832-10	1997	One of the most striking effects of cadmium loading on iron metabolism was increased uptake of [125I]transferrin by the heart, possibly by disrupting the process of receptor-mediated endocytosis and recycling of transferrin by heart muscle.	Iron	55-59	transferrin	Rattus norvegicus	101-112
9282313-0	1997	Effects of iron chelates on the transferrin-free culture of rat dermal fibroblasts through active oxygen generation.	Iron	11-15	transferrin	Rattus norvegicus	32-43
9282313-4	1997	Iron may be essential for survival of fibroblasts because subconfluent fibroblasts exposed to 100 microM FeSO4 in combination with transferrin, HEPES, or GG significantly decreased to release lactate dehydrogenase into the medium.	Iron	0-4	transferrin	Rattus norvegicus	131-142
9252093-0	1997	Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats.	Iron	20-24	transferrin	Rattus norvegicus	105-116
9252093-0	1997	Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats.	Iron	123-127	transferrin	Rattus norvegicus	105-116
9252093-1	1997	BACKGROUND/AIMS: It is well documented that levels of plasma non-transferrin-bound iron (NTBI), a particularly toxic form of iron, are increased in iron overload disorders.	Iron	83-87	transferrin	Rattus norvegicus	65-76
9252093-1	1997	BACKGROUND/AIMS: It is well documented that levels of plasma non-transferrin-bound iron (NTBI), a particularly toxic form of iron, are increased in iron overload disorders.	Iron	125-129	transferrin	Rattus norvegicus	65-76
9487381-24	1997	Normal levels of current iron supply should be guaranteed by oral iron support during erythropoietin treatment.	Iron	66-70	erythropoietin	Homo sapiens	86-100
9221832-10	1997	One of the most striking effects of cadmium loading on iron metabolism was increased uptake of [125I]transferrin by the heart, possibly by disrupting the process of receptor-mediated endocytosis and recycling of transferrin by heart muscle.	Iron	55-59	transferrin	Rattus norvegicus	212-223
9224697-5	1997	Compounds 1 and 2 acted as type II ligands to the heme iron present in the active site of aromatase cytochrome P450 (P450arom).	Iron	55-59	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	117-125
9183380-0	1997	Differential induction of polyamine oxidase activity in liver and heart of iron-overloaded rats.	Iron	75-79	polyamine oxidase	Rattus norvegicus	26-43
9183380-1	1997	The present study was undertaken to investigate the effect of iron dextran treatment on polyamine oxidase (PAO) activity, iron accumulation, and lipid peroxidation in livers and hearts of rats.	Iron	62-66	polyamine oxidase	Rattus norvegicus	88-105
9183380-4	1997	The rats were given iron dextran daily for 7 d. In iron-dextran-treated rats, a marked increase in the hepatic level of iron was associated with enhanced lipid peroxidation and increased PAO activity.	Iron	20-24	polyamine oxidase	Rattus norvegicus	187-190
9183380-8	1997	These results show that although iron dextran treatment results in accumulation of iron in both liver and heart, it induces PAO activity only in liver.	Iron	33-37	polyamine oxidase	Rattus norvegicus	124-127
9183380-9	1997	The significance of increased PAO activity in lipid peroxidation and fibrosis in iron-mediated injury is discussed.	Iron	81-85	polyamine oxidase	Rattus norvegicus	30-33
9177190-2	1997	Reduced carboxymethylated cytochrome c (CmCyt c) with carbon monoxide bound to the heme iron is mixed with the oxidized acceptor protein.	Iron	88-92	cytochrome c, somatic	Homo sapiens	26-38
9200812-1	1997	High-affinity iron uptake in Saccharomyces cerevisiae involves the extracytoplasmic reduction of ferric ions by FRE1 and FRE2 reductases.	Iron	14-18	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	112-116
9227791-3	1997	Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P &lt; 0.001) as compared with the control group.	Iron	27-31	glutathione peroxidase 1	Rattus norvegicus	94-100
9227791-4	1997	The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P &lt; 0.001) or the only L-thyroxine-administered hyperthyroid group (P &lt; 0.001, P &lt; 0.05, P &lt; 0.01, respectively).	Iron	70-74	glutathione peroxidase 1	Rattus norvegicus	21-27
9202792-0	1997	Iron status of children with short stature during accelerated growth due to growth hormone treatment.	Iron	0-4	growth hormone 1	Homo sapiens	76-90
9227791-5	1997	The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.	Iron	70-74	glutathione peroxidase 1	Rattus norvegicus	106-112
9227470-11	1997	These results demonstrate that the iron chelator effectively blocks NF-kappa B activation and coordinate TNF-alpha and IL-6 gene upregulation by HM in cholestatic liver injury or under in vitro lipopolysaccharide stimulation.	Iron	35-39	tumor necrosis factor	Rattus norvegicus	105-114
9209004-7	1997	Whereas in the epoetin beta patients the preoperative change in HR fraction showed negative correlations with transferrin saturation at baseline (P = 0.0058) and with the preoperative change in iron (P = 0.0113), the preoperative change in the LR fraction correlated positively with transferrin at baseline (P = 0.0115).	Iron	194-198	erythropoietin	Homo sapiens	15-22
9227470-11	1997	These results demonstrate that the iron chelator effectively blocks NF-kappa B activation and coordinate TNF-alpha and IL-6 gene upregulation by HM in cholestatic liver injury or under in vitro lipopolysaccharide stimulation.	Iron	35-39	interleukin 6	Rattus norvegicus	119-123
9341082-5	1997	For one of these series (Nusplingen, district Balingen, Schwabische A1b), habitat specific properties have already been assumed to be responsible for an insufficient iron supply of the inhabitants.	Iron	166-170	syntrophin beta 1	Homo sapiens	68-71
9185768-0	1997	Intestinal absorption and enterohepatic cycling of biliary iron originating from plasma non-transferrin-bound iron in rats.	Iron	59-63	transferrin	Rattus norvegicus	92-103
9185768-0	1997	Intestinal absorption and enterohepatic cycling of biliary iron originating from plasma non-transferrin-bound iron in rats.	Iron	110-114	transferrin	Rattus norvegicus	92-103
9185768-1	1997	In iron overload, non-transferrin-bound iron (NTBI) is found in plasma and is rapidly removed by hepatocytes.	Iron	3-7	transferrin	Rattus norvegicus	22-33
9185768-1	1997	In iron overload, non-transferrin-bound iron (NTBI) is found in plasma and is rapidly removed by hepatocytes.	Iron	40-44	transferrin	Rattus norvegicus	22-33
9185768-10	1997	We conclude that biliary iron, originating from NTBI, is absorbed from the intestine, and undergoes enterohepatic circulation if transferrin is saturated.	Iron	25-29	transferrin	Rattus norvegicus	129-140
9211521-2	1997	Recently, the hepatic iron concentration has been reported to influence the outcome of IFN-alpha therapy for chronic viral hepatitis.	Iron	22-26	interferon alpha 1	Homo sapiens	87-96
9180188-4	1997	CD4 T cells from spleens of iron-overloaded mice were found to produce high levels of IL-4 and IL-10 and low levels of interferon-gamma.	Iron	28-32	interleukin 10	Mus musculus	95-100
9180188-4	1997	CD4 T cells from spleens of iron-overloaded mice were found to produce high levels of IL-4 and IL-10 and low levels of interferon-gamma.	Iron	28-32	interferon gamma	Mus musculus	119-135
9255642-9	1997	One patient in multi-organ failure displayed bleomycin-detectable iron in plasma (1.16 mumol/l) and had 100% iron-saturation of transferrin.	Iron	109-113	transferrin	Homo sapiens	128-139
9255642-11	1997	The plasma transferrin levels were also low but resulted in a near normal percentage saturation of transferrin with iron (34.6 +/- 6.5%).	Iron	116-120	transferrin	Homo sapiens	11-22
9255642-11	1997	The plasma transferrin levels were also low but resulted in a near normal percentage saturation of transferrin with iron (34.6 +/- 6.5%).	Iron	116-120	transferrin	Homo sapiens	99-110
9255642-13	1997	CONCLUSIONS: Patients with septic shock rarely have iron saturated transferrin in their plasma leading to the presence of bleomycin-detectable iron.	Iron	143-147	transferrin	Homo sapiens	67-78
9159129-0	1997	Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.	Iron	86-90	Vps41p	Saccharomyces cerevisiae S288C	20-25
9159129-1	1997	Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.	Iron	66-70	Vps41p	Saccharomyces cerevisiae S288C	28-33
9260868-2	1997	In order to investigate whether ICRF-187 might exert its effects by modulating iron metabolism, we studied the drug"s potential to influence the maintenance of iron homeostasis in two human cell lines.	Iron	79-83	regenerating family member 1 alpha	Homo sapiens	32-36
9153234-1	1997	Fre1p and Fre2p are ferric reductases which account for the total plasma membrane associated activity, a prerequisite for iron uptake, in Saccharomyces cerevisiae.	Iron	122-126	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-5
9153234-8	1997	However, only Fre1p activity is induced by copper depletion, even in the presence of iron.	Iron	85-89	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	14-19
9153296-0	1997	Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes.	Iron	113-117	tumor necrosis factor	Homo sapiens	29-37
9153296-0	1997	Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes.	Iron	113-117	tumor necrosis factor	Homo sapiens	186-194
9153296-0	1997	Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes.	Iron	200-204	tumor necrosis factor	Homo sapiens	29-37
9153296-0	1997	Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes.	Iron	200-204	tumor necrosis factor	Homo sapiens	186-194
9153296-5	1997	The enhanced permissiveness of CytD-preincubated monocytes was found to be due to TNFalpha, however, the ability of iron to suppress M. tuberculosis growth also required preincubation with TNFalpha.	Iron	116-120	tumor necrosis factor	Homo sapiens	189-197
9153296-6	1997	Iron-mediated growth suppression was correlated with selective suppression of TNFalpha release from infected monocytes.	Iron	0-4	tumor necrosis factor	Homo sapiens	78-86
9153296-7	1997	In addition, removal of TNFalpha from CytD-treated monocytes 2 d after infection mimicked the suppressive effect of iron, suggesting that iron may also be decreasing monocyte sensitivity to exogenously added TNFalpha.	Iron	116-120	tumor necrosis factor	Homo sapiens	208-216
9153296-7	1997	In addition, removal of TNFalpha from CytD-treated monocytes 2 d after infection mimicked the suppressive effect of iron, suggesting that iron may also be decreasing monocyte sensitivity to exogenously added TNFalpha.	Iron	138-142	tumor necrosis factor	Homo sapiens	24-32
9153296-7	1997	In addition, removal of TNFalpha from CytD-treated monocytes 2 d after infection mimicked the suppressive effect of iron, suggesting that iron may also be decreasing monocyte sensitivity to exogenously added TNFalpha.	Iron	138-142	tumor necrosis factor	Homo sapiens	208-216
9153296-10	1997	The results of this study indicate that TNFalpha preincubation is required for human monocytes to exert an iron-mediated suppressive effect on M. tuberculosis growth.	Iron	107-111	tumor necrosis factor	Homo sapiens	40-48
9153296-12	1997	Iron may be an important early modulator of M. tuberculosis growth via its effects on TNFalpha.	Iron	0-4	tumor necrosis factor	Homo sapiens	86-94
9260868-3	1997	We demonstrate that ICRF-187 enhanced the binding affinity of iron regulatory protein (IRP), the central regulatory factor for posttranscriptional iron regulation, to RNA stem loop structures, called iron responsive elements (IRE), in THP-1 myelomonocytic as well as K562 erythroleukemic cells.	Iron	62-66	regenerating family member 1 alpha	Homo sapiens	20-24
9260868-3	1997	We demonstrate that ICRF-187 enhanced the binding affinity of iron regulatory protein (IRP), the central regulatory factor for posttranscriptional iron regulation, to RNA stem loop structures, called iron responsive elements (IRE), in THP-1 myelomonocytic as well as K562 erythroleukemic cells.	Iron	62-66	GLI family zinc finger 2	Homo sapiens	235-240
9260868-3	1997	We demonstrate that ICRF-187 enhanced the binding affinity of iron regulatory protein (IRP), the central regulatory factor for posttranscriptional iron regulation, to RNA stem loop structures, called iron responsive elements (IRE), in THP-1 myelomonocytic as well as K562 erythroleukemic cells.	Iron	147-151	regenerating family member 1 alpha	Homo sapiens	20-24
9260868-3	1997	We demonstrate that ICRF-187 enhanced the binding affinity of iron regulatory protein (IRP), the central regulatory factor for posttranscriptional iron regulation, to RNA stem loop structures, called iron responsive elements (IRE), in THP-1 myelomonocytic as well as K562 erythroleukemic cells.	Iron	147-151	GLI family zinc finger 2	Homo sapiens	235-240
9260868-5	1997	Subsequently, ICRF-187 treatment of cells increased trf-rec surface expression and enhanced cellular iron uptake.	Iron	101-105	regenerating family member 1 alpha	Homo sapiens	14-18
9260868-7	1997	Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction.	Iron	47-51	regenerating family member 1 alpha	Homo sapiens	67-71
9260868-7	1997	Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction.	Iron	47-51	regenerating family member 1 alpha	Homo sapiens	121-125
9260868-7	1997	Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction.	Iron	146-150	regenerating family member 1 alpha	Homo sapiens	67-71
9260868-7	1997	Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction.	Iron	146-150	regenerating family member 1 alpha	Homo sapiens	121-125
9260868-7	1997	Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction.	Iron	146-150	regenerating family member 1 alpha	Homo sapiens	67-71
9260868-7	1997	Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction.	Iron	146-150	regenerating family member 1 alpha	Homo sapiens	121-125
9115299-2	1997	The iron chelator desferrioxamine (DFX) induces the activity of the human erythropoietin enhancer in Hep3B cells.	Iron	4-8	erythropoietin	Homo sapiens	74-88
9115232-7	1997	The level of FET4 closely correlated with uptake activity over a broad range of expression levels and is itself regulated by iron.	Iron	125-129	Fet4p	Saccharomyces cerevisiae S288C	13-17
9115299-0	1997	Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine.	Iron	130-134	nitric oxide synthase 2	Homo sapiens	82-113
9115299-7	1997	We also investigated the role of iron metabolism in the DFX- or PA-dependent induction of HIF-1 activity and iNOS expression.	Iron	33-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-95
9115299-10	1997	Furthermore, our results indicate that the iNOS-HRE is a regulatory element of the iNOS promoter responsive to iron chelation.	Iron	111-115	nitric oxide synthase 2	Homo sapiens	43-47
9115299-10	1997	Furthermore, our results indicate that the iNOS-HRE is a regulatory element of the iNOS promoter responsive to iron chelation.	Iron	111-115	nitric oxide synthase 2	Homo sapiens	83-87
9175950-1	1997	AIM: To evaluate the role of recombinant human erythropoietin (R-HuEpo) in reducing iron infusion, which may exacerbate free radical damage, leading to chronic lung disease.	Iron	84-88	erythropoietin	Homo sapiens	47-61
9145923-11	1997	The chelator-mediated translocation of iron from cells to medium was assessed in 55Fe-transferrin-loaded K562 cells.	Iron	39-43	transferrin	Homo sapiens	86-97
9208284-7	1997	It is concluded that the iron-Tf saturation influences the Tf binding of aluminum not only by occupying binding sites otherwise available for aluminum, but also by lowering the affinity of Tf for aluminum.	Iron	25-29	transferrin	Homo sapiens	30-32
9208284-7	1997	It is concluded that the iron-Tf saturation influences the Tf binding of aluminum not only by occupying binding sites otherwise available for aluminum, but also by lowering the affinity of Tf for aluminum.	Iron	25-29	transferrin	Homo sapiens	59-61
9208284-7	1997	It is concluded that the iron-Tf saturation influences the Tf binding of aluminum not only by occupying binding sites otherwise available for aluminum, but also by lowering the affinity of Tf for aluminum.	Iron	25-29	transferrin	Homo sapiens	59-61
9175038-0	1997	The management of iron metabolism in recombinant human erythropoietin treated dialysis patients by Dutch nephrologists.	Iron	18-22	erythropoietin	Homo sapiens	55-69
9385081-19	1997	Visualization of cellular HO-2 expression aids in assessment of potential sites of carbon monoxide, iron, and bilirubin production within the nervous system.	Iron	100-104	heme oxygenase 2	Rattus norvegicus	26-30
9208284-0	1997	Competition of iron and aluminum for transferrin: the molecular basis for aluminum deposition in iron-overloaded dialysis patients?	Iron	97-101	transferrin	Homo sapiens	37-48
9208284-4	1997	After we incubated apo-Tf with iron and aluminum which were added in amounts equivalent to the calculated number of metal-binding sites on the protein (i.e., 2 mol metal/mol Tf), we found that Tf can be saturated for 100% with iron.	Iron	31-35	transferrin	Homo sapiens	23-25
9208284-4	1997	After we incubated apo-Tf with iron and aluminum which were added in amounts equivalent to the calculated number of metal-binding sites on the protein (i.e., 2 mol metal/mol Tf), we found that Tf can be saturated for 100% with iron.	Iron	31-35	transferrin	Homo sapiens	174-176
9208284-4	1997	After we incubated apo-Tf with iron and aluminum which were added in amounts equivalent to the calculated number of metal-binding sites on the protein (i.e., 2 mol metal/mol Tf), we found that Tf can be saturated for 100% with iron.	Iron	31-35	transferrin	Homo sapiens	174-176
9208284-4	1997	After we incubated apo-Tf with iron and aluminum which were added in amounts equivalent to the calculated number of metal-binding sites on the protein (i.e., 2 mol metal/mol Tf), we found that Tf can be saturated for 100% with iron.	Iron	227-231	transferrin	Homo sapiens	23-25
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	21-25	transferrin	Homo sapiens	3-5
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9208284-6	1997	In Tf solutions with iron saturations ranging between 0 and 60% as well as in the serum of 15 subjects with iron-Tf saturations varying between 12 and 48%, a significant (p &lt; 0.001) negative correlation between the degree of iron-Tf saturation and the percentage of aluminum (added in amounts equivalent to the number of the remaining binding sites on Tf) bound to Tf was noted (y = -0.26x + 24.5, r = -0.87 in serum).	Iron	108-112	transferrin	Homo sapiens	113-115
9109516-7	1997	Stretch-induced increases in PC biosynthesis and PCT activity correlated well (r = 0.983) and were significantly reduced by pretreating (1 h) the cells with an iron chelator (deferoxamine) or scavengers of reactive oxygen species such as superoxide dismutase and catalase.	Iron	160-164	catalase	Rattus norvegicus	263-271
9160313-8	1997	Transferrin saturation was more than 50% in 6 (29%) of 21 cases with increased hepatic iron levels and in 6 (14%) of 42 cases with little or no hepatic iron.	Iron	87-91	transferrin	Homo sapiens	0-11
9160313-8	1997	Transferrin saturation was more than 50% in 6 (29%) of 21 cases with increased hepatic iron levels and in 6 (14%) of 42 cases with little or no hepatic iron.	Iron	152-156	transferrin	Homo sapiens	0-11
9160313-9	1997	These results indicate that hepatic iron overload in patients with AIDS is associated with blood transfusions, an elevated transferrin saturation, and Mycobacterium avium-Mycobacterium intracellulare infection.	Iron	36-40	transferrin	Homo sapiens	123-134
9296078-3	1997	A positive iron balance (serum iron &gt; 27 mumol/l and transferrin saturation &gt; 45%) was found in 1.6% of the male subjects, a frequency which could be explained by the presence of the hemochromatosis genes.	Iron	11-15	transferrin	Homo sapiens	56-67
9265238-18	1997	Greater iron consumption, illustrated by higher transferrin saturation, also confirmed increased erythopoitesis in patients undergoing continuous ambulatory peritoneal dialysis.	Iron	8-12	transferrin	Homo sapiens	48-59
9109411-1	1997	A recombinant truncated form (delta1-102/delta428-452) of the non-heme iron-dependent metalloenzyme human phenylalanine hydroxylase (hPAH, phenylalanine 4-monooxygenase; EC 1.14.16.1) was expressed in E. coli, purified to homogeneity as a homodimer (70 kDa) and crystallized using the hanging drop vapour diffusion method.	Iron	71-75	superoxide dismutase 1	Homo sapiens	239-248
9100046-4	1997	The EPO doses and s-CRP were both inversely correlated to the levels of serum albumin and serum iron, suggesting that the principal mechanism by which inflammatory cytokines inhibit erythropoiesis is coupled to iron metabolism, ie, functional iron deficiency.	Iron	96-100	erythropoietin	Homo sapiens	4-7
9100046-4	1997	The EPO doses and s-CRP were both inversely correlated to the levels of serum albumin and serum iron, suggesting that the principal mechanism by which inflammatory cytokines inhibit erythropoiesis is coupled to iron metabolism, ie, functional iron deficiency.	Iron	211-215	erythropoietin	Homo sapiens	4-7
9116301-3	1997	In RE cells of GH subjects, we examined the activity of iron regulatory protein (IRP), a reliable indicator of the elusive regulatory labile iron pool, which modulates cellular iron homeostasis through control of ferritin (Ft) and transferrin receptor gene expression.	Iron	56-60	transferrin	Homo sapiens	231-242
9111021-1	1997	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation.	Iron	270-274	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
9111021-1	1997	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation.	Iron	270-274	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
9111021-1	1997	Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation.	Iron	270-274	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-159
9131042-2	1997	In these studies, a short pulse of 450 nm light was used to excite the ruthenium complex which was oxidatively quenched by the iron center of cytochrome c.	Iron	127-131	cytochrome c, somatic	Homo sapiens	142-154
9088667-2	1997	These mechanisms include decreased beta-cell secretion of insulin due to iron overload, insulin resistance and genetic factors.	Iron	73-77	insulin	Homo sapiens	58-65
9138275-4	1997	One day after iron treatment, an increase in AST, ALT and MDA release was observed with 50 or 100 microM of iron citrate; it appeared that the concentrations 50 and 100 microM of iron were highly toxic for human hepatocytes.	Iron	14-18	solute carrier family 17 member 5	Homo sapiens	45-48
9138275-4	1997	One day after iron treatment, an increase in AST, ALT and MDA release was observed with 50 or 100 microM of iron citrate; it appeared that the concentrations 50 and 100 microM of iron were highly toxic for human hepatocytes.	Iron	108-112	solute carrier family 17 member 5	Homo sapiens	45-48
9086290-1	1997	The description by Ramsay in 1957 of a practical way of determining the total iron binding capacity of serum (a measure of transferrin concentration) provided a diagnostic test for both iron deficiency and iron overload.	Iron	78-82	transferrin	Homo sapiens	123-134
9105556-6	1997	Iron in plasma is carried by the protein transferrin.	Iron	0-4	transferrin	Homo sapiens	41-52
9105556-7	1997	Lowering the pH releases some of the iron from transferrin so that it can catalyse LDL oxidation.	Iron	37-41	transferrin	Homo sapiens	47-58
9200269-12	1997	CRP also showed, together with iron, the earliest response to recovery in the patients.	Iron	31-35	C-reactive protein	Homo sapiens	0-3
9200269-15	1997	CRP showed the greatest amplitude of changes and together with iron and percentage saturation of transferrin it also showed the earliest response to recovery in patients with CAP.	Iron	63-67	C-reactive protein	Homo sapiens	0-3
9086290-1	1997	The description by Ramsay in 1957 of a practical way of determining the total iron binding capacity of serum (a measure of transferrin concentration) provided a diagnostic test for both iron deficiency and iron overload.	Iron	186-190	transferrin	Homo sapiens	123-134
9041207-1	1997	One of the important components of successful anemia therapy in patients with end-stage renal disease (ESRD) treated with recombinant human erythropoietin is the maintenance of adequate available iron.	Iron	196-200	erythropoietin	Homo sapiens	140-154
9074650-1	1997	Transferrin, as the major iron-transport protein in serum and other body fluids, has a central role in managing iron the body receives.	Iron	26-30	transferrin	Homo sapiens	0-11
9074650-7	1997	The study indicates that lead suppresses human transferrin synthesis by a mechanism that differs from the hepatic acute phase response and that lead may also affect iron metabolism in humans by interfering with transferrin levels.	Iron	165-169	transferrin	Homo sapiens	211-222
9325434-11	1997	Cellular Fe uptake and storage are coordinately regulated through a feedback control mechanism mediated at the post-transcriptional level by cytoplasmic factors known as IRP1 and IRP2.	Iron	9-11	iron responsive element binding protein 2	Homo sapiens	179-183
9125127-2	1997	scavenging activity of erythromycin (EM) and of EM-iron complex by means of electron spin resonance spectroscopy, luminol-dependent chemiluminescence assay, and cytochrome c reduction assay.	Iron	51-55	cytochrome c, somatic	Homo sapiens	161-173
9041227-7	1997	Although the dogma is that the myoglobin is the source of iron, the results of recent studies suggest that cytochrome P-450 may be an important source of iron in this model.	Iron	154-158	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	107-123
9054659-1	1997	Iron transport in reticulocytes is known to occur via the well-described transferrin-receptor-endosome pathway.	Iron	0-4	transferrin	Homo sapiens	73-84
9054659-5	1997	This demonstrated that the reticulocyte transferrin independent pathway for iron transport involved integrins and mobilferrin similar to intestinal absorptive cells.	Iron	76-80	transferrin	Homo sapiens	40-51
9111950-4	1997	The iron transport protein transferrin showed distinct differences in adsorption to a variety of hydroxyapatite and tricalcium phosphate powders, with higher concentrations of transferrin adsorbed to powders which caused no change or a drop in the pH of cell culture medium or water.	Iron	4-8	transferrin	Homo sapiens	27-38
9111950-4	1997	The iron transport protein transferrin showed distinct differences in adsorption to a variety of hydroxyapatite and tricalcium phosphate powders, with higher concentrations of transferrin adsorbed to powders which caused no change or a drop in the pH of cell culture medium or water.	Iron	4-8	transferrin	Homo sapiens	176-187
9054659-2	1997	An alternative pathway for iron transport independent of transferrin has been postulated in reticulocytes and other cells.	Iron	27-31	transferrin	Homo sapiens	57-68
9051399-0	1997	Body iron stores are associated with serum insulin and blood glucose concentrations.	Iron	5-9	insulin	Homo sapiens	43-50
9110146-0	1997	Iron chelation decreases human immunodeficiency virus-1 Tat potentiated tumor necrosis factor-induced NF-kappa B activation in Jurkat cells.	Iron	0-4	nuclear factor kappa B subunit 1	Homo sapiens	102-112
9110146-12	1997	in the presence of iron ions play a major role in HIV-1 Tat enhancement of TNF-induced NF-kappa B activation and that iron chelation may protect Jurkat T cells, at least in part, against oxidative stress induced by Tat.	Iron	19-23	tumor necrosis factor	Homo sapiens	75-78
9118657-14	1997	High plasma iron concentrations with a lower level of transferrin, postcardiopulmonary bypass, gave significantly increased mean percentage iron-saturation of transferrin, increasing from 27.1% to 61.7% (p &lt; .01).	Iron	12-16	transferrin	Homo sapiens	159-170
9118657-14	1997	High plasma iron concentrations with a lower level of transferrin, postcardiopulmonary bypass, gave significantly increased mean percentage iron-saturation of transferrin, increasing from 27.1% to 61.7% (p &lt; .01).	Iron	140-144	transferrin	Homo sapiens	54-65
9118657-14	1997	High plasma iron concentrations with a lower level of transferrin, postcardiopulmonary bypass, gave significantly increased mean percentage iron-saturation of transferrin, increasing from 27.1% to 61.7% (p &lt; .01).	Iron	140-144	transferrin	Homo sapiens	159-170
9118657-16	1997	In 90% of the cardiopulmonary bypass patients, there was a significant correlation between the percent increase in iron saturation of transferrin and the protein accumulation index.	Iron	115-119	transferrin	Homo sapiens	134-145
9118657-20	1997	In the majority of patients, there was a significant correlation between the iron saturation of transferrin and the protein accumulation index.	Iron	77-81	transferrin	Homo sapiens	96-107
9110146-12	1997	in the presence of iron ions play a major role in HIV-1 Tat enhancement of TNF-induced NF-kappa B activation and that iron chelation may protect Jurkat T cells, at least in part, against oxidative stress induced by Tat.	Iron	19-23	nuclear factor kappa B subunit 1	Homo sapiens	87-97
9110146-4	1997	This study shows that treatment of Jurkat cells with iron chelator deferoxamine (DFO) strongly decreases HIV-1 Tat-potentiated TNF-induced NF-kappa B activation but does not modify NF-kappa B activation by TNF-alpha.	Iron	53-57	tumor necrosis factor	Homo sapiens	127-130
9110146-4	1997	This study shows that treatment of Jurkat cells with iron chelator deferoxamine (DFO) strongly decreases HIV-1 Tat-potentiated TNF-induced NF-kappa B activation but does not modify NF-kappa B activation by TNF-alpha.	Iron	53-57	nuclear factor kappa B subunit 1	Homo sapiens	139-149
9110146-4	1997	This study shows that treatment of Jurkat cells with iron chelator deferoxamine (DFO) strongly decreases HIV-1 Tat-potentiated TNF-induced NF-kappa B activation but does not modify NF-kappa B activation by TNF-alpha.	Iron	53-57	tumor necrosis factor	Homo sapiens	206-209
9110146-5	1997	The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.)	Iron	15-19	tumor necrosis factor	Homo sapiens	56-59
9110146-5	1997	The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.)	Iron	15-19	nuclear factor kappa B subunit 1	Homo sapiens	68-78
9110146-5	1997	The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.)	Iron	110-114	tumor necrosis factor	Homo sapiens	56-59
9110146-5	1997	The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.)	Iron	110-114	nuclear factor kappa B subunit 1	Homo sapiens	68-78
9042969-0	1997	Newly delivered transferrin iron and oxidative cell injury.	Iron	28-32	transferrin	Homo sapiens	16-27
9244773-7	1997	A reduction in serum haptoglobin concentration was shown to be accompanied by a decrease of serum iron concentration.	Iron	98-102	haptoglobin	Homo sapiens	21-32
9073575-2	1997	More specifically, the activity of two [Fe-S] enzymes was followed during the course of NO synthase expression:mitochondrial aconitase, which catalyzes citrate:isocitrate conversion in the Krebs cycle, and cytoplasmic aconitase, or iron regulatory protein (IRP), a trans-regulator that controls expression at the posttranscriptional level of proteins involved in iron metabolism.	Iron	40-44	aconitase 2	Homo sapiens	111-134
9078545-11	1997	We conclude that, although erythropoietin treatment stimulates erythrocyte iron incorporation in premature infants, it has no effect on iron absorption at the r-HuEPO dose studied.	Iron	75-79	erythropoietin	Homo sapiens	27-41
9047321-11	1997	To explain the mode via which the phenolic hydroxyl facilitates ortho hydroxylation, a mechanism in which the phenolic moiety attacks the iron-oxo double bond of CYP3A4, resulting in oxygen transfer to the ortho position, is proposed.	Iron	138-142	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	162-168
9042969-2	1997	Cultured K562 cells, which maintain a stable cytosolic labile iron pool (LIP) of &lt; 0.5 microM, underwent distinct changes after short exposures to transferrin (Tf) followed by t-butyl hydroperoxide (TBHP): (a) rise in LIP, detectable fluorimetrically; (b) increased lipid peroxidation and (c) eventual cell death.	Iron	62-66	transferrin	Homo sapiens	150-161
9025273-1	1997	Iron(III) in cytochrome c is replaced with zinc(II) by a modification of a method published by others, and the procedure is described in full detail.	Iron	0-4	cytochrome c, somatic	Homo sapiens	13-25
9025273-2	1997	Three forms of cytochrome c-those containing iron(III), iron(II), and zinc(II)-are examined by circular dichroism spectroscopy and resonance Raman spectroscopy.	Iron	45-49	cytochrome c, somatic	Homo sapiens	15-27
9025273-2	1997	Three forms of cytochrome c-those containing iron(III), iron(II), and zinc(II)-are examined by circular dichroism spectroscopy and resonance Raman spectroscopy.	Iron	56-60	cytochrome c, somatic	Homo sapiens	15-27
9003001-6	1997	Sertoli cells produce transferrin to transport iron to developing spermatogenic cells sequestered within the blood-testis barrier.	Iron	47-51	transferrin	Homo sapiens	22-33
9074795-2	1997	Although studies with immature erythroid cells obtained from animals have shown that increased intracellular hemin inhibits the acquisition of iron from transferrin, our experiments with human reticulocytes indicate that feedback inhibition of heme biosynthesis is primarily regulated at one or more steps that lead to formation of the first committed precursor, delta-aminolevulinate (ALA).	Iron	143-147	transferrin	Homo sapiens	153-164
9049024-1	1997	In the human body, the concentration of free iron is limiting for bacterial growth, since iron is bound to transport and storage proteins such as transferrin and lactoferrin.	Iron	45-49	transferrin	Homo sapiens	146-157
9049024-1	1997	In the human body, the concentration of free iron is limiting for bacterial growth, since iron is bound to transport and storage proteins such as transferrin and lactoferrin.	Iron	90-94	transferrin	Homo sapiens	146-157
9006022-8	1997	Expression of both CvaA and CvaA* was induced by the iron chelator 2,2"-dipyridyl, indicating that cvaA is negatively regulated at least partially by Fur.	Iron	53-57	CvaA	Escherichia coli	19-23
9006022-8	1997	Expression of both CvaA and CvaA* was induced by the iron chelator 2,2"-dipyridyl, indicating that cvaA is negatively regulated at least partially by Fur.	Iron	53-57	CvaA	Escherichia coli	28-32
9006022-8	1997	Expression of both CvaA and CvaA* was induced by the iron chelator 2,2"-dipyridyl, indicating that cvaA is negatively regulated at least partially by Fur.	Iron	53-57	CvaA	Escherichia coli	99-103
8995275-5	1997	Both fio1+ and fip1+ are transcriptionally regulated by iron need, and disruption of fio1+ results in a loss of high affinity iron transport.	Iron	56-60	cleavage polyadenylation factor subunit FIP1	Saccharomyces cerevisiae S288C	15-19
9027736-3	1997	Epo production is induced not only by hypoxia but also by certain transition metal (cobalt and nickel) and by iron chelation.	Iron	110-114	erythropoietin	Homo sapiens	0-3
9027736-4	1997	When Hep3B cells were incubated in an iron deficient medium, Epo mRNA expression was enhanced fourfold compared to Hep3B cells in iron enriched medium.	Iron	38-42	erythropoietin	Homo sapiens	61-64
9027736-5	1997	Epo induction by cobalt was inversely related to iron concentration in the medium, indicating competition between the two metals.	Iron	49-53	erythropoietin	Homo sapiens	0-3
9029643-0	1997	Body iron stores decrease in boys during pubertal development: the transferrin receptor-ferritin ratio as an indicator of iron status.	Iron	122-126	transferrin	Homo sapiens	67-78
18966745-6	1997	Considerable quantities of iron in UNS, UNF, UNR and UNRC cause interference.	Iron	27-31	cold shock domain containing E1	Homo sapiens	45-48
9006892-0	1997	Polyvalent cationic metals induce the rate of transferrin-independent iron acquisition by HL-60 cells.	Iron	70-74	transferrin	Homo sapiens	46-57
9037489-2	1997	The large surface area of the blood-brain barrier capillaries and the presence of transferrin receptors on the luminal plasma membranes of the blood-brain barrier endothelial cells (BBB-ECs) suggest that these cells actively participate in the transport of iron into the brain.	Iron	257-261	transferrin	Homo sapiens	82-93
9002972-0	1997	Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells.	Iron	23-27	erythropoietin	Homo sapiens	42-56
9002972-2	1997	Because a sufficient supply of iron is a prerequisite for erythroid proliferation and hemoglobin synthesis, we have investigated whether Epo can regulate cellular iron metabolism.	Iron	163-167	erythropoietin	Homo sapiens	137-140
9002972-3	1997	We present here a novel biologic function of Epo, namely as a potential modulator of cellular iron homeostasis.	Iron	94-98	erythropoietin	Homo sapiens	45-48
9002972-5	1997	Activation of IRP-1 by Epo is associated with a marked increase in transferrin receptor (trf-rec) mRNA levels in K562 and MEL, enhanced cell surface expression of trf-recs, and increased uptake of iron into cells.	Iron	197-201	erythropoietin	Homo sapiens	23-26
9002972-8	1997	Our results provide evidence for a direct functional connection between Epo biology and iron metabolism by which Epo increases iron uptake into erythroid progenitor cells via posttranscriptional induction of trf-rec expression.	Iron	88-92	erythropoietin	Homo sapiens	72-75
9002972-8	1997	Our results provide evidence for a direct functional connection between Epo biology and iron metabolism by which Epo increases iron uptake into erythroid progenitor cells via posttranscriptional induction of trf-rec expression.	Iron	88-92	erythropoietin	Homo sapiens	113-116
9002972-8	1997	Our results provide evidence for a direct functional connection between Epo biology and iron metabolism by which Epo increases iron uptake into erythroid progenitor cells via posttranscriptional induction of trf-rec expression.	Iron	127-131	erythropoietin	Homo sapiens	72-75
9002972-8	1997	Our results provide evidence for a direct functional connection between Epo biology and iron metabolism by which Epo increases iron uptake into erythroid progenitor cells via posttranscriptional induction of trf-rec expression.	Iron	127-131	erythropoietin	Homo sapiens	113-116
9002972-9	1997	Our data suggest that sequential administration of Epo and iron might improve the response to Epo therapy in some anemias.	Iron	59-63	erythropoietin	Homo sapiens	94-97
8995397-1	1997	Aldehyde oxidase and xanthine dehydrogenase are a group of ubiquitous hydroxylases, containing a molybdenum cofactor (MoCo) and two iron-sulfur groups.	Iron	132-136	aldehyde oxidase	Solanum lycopersicum	0-16
9127455-0	1997	Components of biological variation in serum soluble transferrin receptor: relationships to serum iron, transferrin and ferritin concentrations, and immune and haematological variables.	Iron	97-101	transferrin	Homo sapiens	52-63
9127455-6	1997	Up to 34.2% of the within-subject variability in TfR (which reflects changes over time) could be explained by the regression on iron, ferritin, Tf, sIL-2R, sIL-6R and MCH values.	Iron	128-132	transferrin	Homo sapiens	49-51
9127455-7	1997	Up to 67.2% of the between-subject variability in TfR (which reflects differences in the homeostatic setpoint during the study year) could be explained by the regression on gender, iron, Tf, and ferritin values.	Iron	181-185	transferrin	Homo sapiens	50-52
9016819-10	1997	Associated with loss of CYP2E1 catalytic activity was a decrease in the formation of superoxide radical and H2O2, in microsomal lipid peroxidation catalyzed by low, but not high concentration of iron, and in consumption of NADPH.	Iron	195-199	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	24-30
8995275-8	1997	Simultaneous expression of both S. pombe genes, fio1+ and fip1+, in S. cerevisiae can reconstitute high affinity iron transport.	Iron	113-117	cleavage polyadenylation factor subunit FIP1	Saccharomyces cerevisiae S288C	58-62
9381969-5	1997	Gallium, indium and the antineoplastic agent cisplatin were bound to the iron binding site of transferrin and inhibit the growth of malignant carcinoma cell lines.	Iron	73-77	transferrin	Homo sapiens	94-105
9066706-3	1997	In cases of iron deficiency, the number of transferrin receptors was increased on part of the erythroblasts thus facilitating iron uptake by the cells.	Iron	12-16	transferrin	Homo sapiens	43-54
9066706-5	1997	This leads to the conclusion that the ineffective response to iron therapy in cases of ACD and MSD can be explained by a decline of transferrin receptors on the red cells.	Iron	62-66	transferrin	Homo sapiens	132-143
9381969-1	1997	Normal iron metabolism can be perturbed with iron chelators, toxic metals that bind to transferrin, toxic metals bound to transferrin or antineoplastic agents covalently linked to transferrin.	Iron	7-11	transferrin	Homo sapiens	87-98
9381969-1	1997	Normal iron metabolism can be perturbed with iron chelators, toxic metals that bind to transferrin, toxic metals bound to transferrin or antineoplastic agents covalently linked to transferrin.	Iron	7-11	transferrin	Homo sapiens	122-133
9381969-1	1997	Normal iron metabolism can be perturbed with iron chelators, toxic metals that bind to transferrin, toxic metals bound to transferrin or antineoplastic agents covalently linked to transferrin.	Iron	7-11	transferrin	Homo sapiens	122-133
15093378-0	1997	Removal of TNT and RDX from water and soil using iron metal.	Iron	49-59	chromosome 16 open reading frame 82	Homo sapiens	11-14
9096447-0	1997	Mathematical approach for estimating iron needs in hemodialysis patients on erythropoietin therapy.	Iron	37-41	erythropoietin	Homo sapiens	76-90
9096447-1	1997	Functional iron deficiency occurs when recombinant human erythropoietin (rHuEPO) accelerates erythropoiesis to an extent that the iron availability cannot meet the anticipated demand.	Iron	11-15	erythropoietin	Homo sapiens	57-71
9066598-10	1997	Since ICRF-187 acts by binding iron, we deem that the earliest cardiac involvement, may occur before iron overload; therefore the role of ICRF-187 and C0Q10 in acute or chronic heart toxicity was correlated with high-dose anthracycline and needs to be further investigated.	Iron	31-35	regenerating family member 1 alpha	Homo sapiens	6-10
9360662-0	1997	Importance of iron saturation for erythropoietin responsiveness in chronic peritoneal dialysis.	Iron	14-18	erythropoietin	Homo sapiens	34-48
8980260-6	1997	In the second phase, the latter cells, in the presence of stem cell factor, hemin, and iron-saturated transferrin, continue to proliferate and mature into hemoglobin (Hb)-containing orthochromatic normoblasts.	Iron	87-91	transferrin	Homo sapiens	102-113
9034408-4	1997	While a coherent, plausible hypothesis as to how transition metals, such as iron, might accelerate the progression of atherosclerosis has been generated from basic research, iron status, measured as dietary iron intake, serum iron, serum ferritin, and transferrin saturation, has been inconsistently associated with cardiovascular disease in human epidemiologic research.	Iron	76-80	transferrin	Homo sapiens	252-263
9192174-5	1997	Iron regulatory proteins are regulated either by assembly or by disassembly of an iron-sulfur cluster (IRP1) or by rapid degradation in the presence of iron (IRP2).	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	158-162
9192174-5	1997	Iron regulatory proteins are regulated either by assembly or by disassembly of an iron-sulfur cluster (IRP1) or by rapid degradation in the presence of iron (IRP2).	Iron	152-156	iron responsive element binding protein 2	Homo sapiens	158-162
9013729-1	1997	Transferrin is the primary iron-binding protein in the plasma.	Iron	27-31	transferrin	Homo sapiens	0-11
15093378-2	1997	Our objective was to determine if zero-valent iron (Fe(0)) could be used to promote remediation of water and soil contaminated with 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).	Iron	46-50	chromosome 16 open reading frame 82	Homo sapiens	155-158
9044879-11	1997	Its novel use for imaging iron-52 transferrin for localising erythropoietic activity demonstrates its sensitivity and resolution advantages over a conventional dual-headed gamma camera.	Iron	26-30	transferrin	Homo sapiens	34-45
15093378-2	1997	Our objective was to determine if zero-valent iron (Fe(0)) could be used to promote remediation of water and soil contaminated with 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).	Iron	52-57	chromosome 16 open reading frame 82	Homo sapiens	155-158
9032812-1	1997	Transferrin (Tf)-dependent iron transfer from mother to fetus is mediated by Tf receptors (TfRs) which are present on both microvillous and basal membranes of human placental syncytiotrophoblast.	Iron	27-31	transferrin	Homo sapiens	0-11
9215812-0	1997	How does superoxide dismutase protect against tumor necrosis factor: a hypothesis informed by effect of superoxide on "free" iron.	Iron	125-129	tumor necrosis factor	Homo sapiens	46-67
9215812-8	1997	MnSOD protects against TNF by decreasing O2- attack on [4Fe-4S] clusters and thus lowering free iron.	Iron	96-100	tumor necrosis factor	Homo sapiens	23-26
9404022-1	1997	Human serum, transferrin, and apotransferrin are known to profoundly inhibit the growth of Candida albicans by iron deprivation.	Iron	111-115	transferrin	Homo sapiens	13-24
9404022-2	1997	On the other hand, iron overload (iron saturated transferrin) is a serious risk factor for candidiasis in newborn and in leukemic patients.	Iron	19-23	transferrin	Homo sapiens	49-60
9404022-2	1997	On the other hand, iron overload (iron saturated transferrin) is a serious risk factor for candidiasis in newborn and in leukemic patients.	Iron	34-38	transferrin	Homo sapiens	49-60
9343841-8	1997	In the NSCLC patients there were significant negative correlations between concentrations of C-reactive protein and iron, transferrin, zinc, albumin, and selenium (p &lt; 0.05).	Iron	116-120	C-reactive protein	Homo sapiens	93-111
8994263-3	1997	IRP-1 and IRP-2 are trans-acting regulators of mRNAs involved in iron uptake, storage and utilisation.	Iron	65-69	iron responsive element binding protein 2	Homo sapiens	10-15
9551665-0	1997	Effect of iron on transferrin receptor expression by human placental syncytiotrophoblast cells.	Iron	10-14	transferrin	Homo sapiens	18-29
9551665-6	1997	In contrast to syncytiotrophoblast, expression of intracellular transferrin receptors in non-differentiated cytotrophoblast cells decreased when cells were cultured with iron salts; this was accompanied by decreased receptor synthesis.	Iron	170-174	transferrin	Homo sapiens	64-75
9551665-10	1997	These characteristics of syncytiotrophoblast transferrin receptor expression may assist in ensuring a supply of iron to the fetus regardless of the maternal iron status.	Iron	112-116	transferrin	Homo sapiens	45-56
9551665-10	1997	These characteristics of syncytiotrophoblast transferrin receptor expression may assist in ensuring a supply of iron to the fetus regardless of the maternal iron status.	Iron	157-161	transferrin	Homo sapiens	45-56
8969195-5	1996	However, murine and human ferritin H subunits also evidenced substantial functional differences; murine ferritin H showed a consistent reduction in iron uptake activity relative to human ferritin H.	Iron	148-152	ferritin mitochondrial	Mus musculus	26-36
8969195-5	1996	However, murine and human ferritin H subunits also evidenced substantial functional differences; murine ferritin H showed a consistent reduction in iron uptake activity relative to human ferritin H.	Iron	148-152	ferritin mitochondrial	Mus musculus	104-114
8969195-5	1996	However, murine and human ferritin H subunits also evidenced substantial functional differences; murine ferritin H showed a consistent reduction in iron uptake activity relative to human ferritin H.	Iron	148-152	ferritin mitochondrial	Mus musculus	104-114
8955082-14	1996	The ligands resulting in the low spin complexes bind directly to the heme iron, while their cognate ligands induce the formation of high spin complexes by indirectly perturbing the heme structure and excluding the original axial heme ligand in the resting eNOS (V. Berka, P.-F. Chen, and A.	Iron	74-78	nitric oxide synthase 3	Homo sapiens	256-260
8958128-6	1997	Both mannitol and catalase were found to offer complete protection against the inhibitory effect of peroxide +/- iron on calcium uptake.	Iron	113-117	catalase	Rattus norvegicus	18-26
8977218-0	1997	Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.	Iron	42-46	interleukin 13	Mus musculus	102-107
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	109-113	interferon gamma	Mus musculus	55-64
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	109-113	toll-like receptor 4	Mus musculus	65-68
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	157-161	interferon gamma	Mus musculus	55-64
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	157-161	toll-like receptor 4	Mus musculus	65-68
8977218-6	1997	The mRNA levels for the membrane receptor for iron uptake, transferrin receptor (TfR), decrease following stimulation with IFN-gamma/LPS, although IRP-mediated stabilization of the TfR mRNA would have been expected.	Iron	46-50	interferon gamma	Mus musculus	123-132
8977218-6	1997	The mRNA levels for the membrane receptor for iron uptake, transferrin receptor (TfR), decrease following stimulation with IFN-gamma/LPS, although IRP-mediated stabilization of the TfR mRNA would have been expected.	Iron	46-50	toll-like receptor 4	Mus musculus	133-136
8977218-8	1997	Thus, IL-4 and IL-13 regulate the iron metabolism of activated macrophages by at least two different pathways: first, by opposing NO-mediated IRP activation, thereby increasing ferritin translation; and second, by an IRP-independent augmentation of TfR mRNA expression.	Iron	34-38	interleukin 13	Mus musculus	15-20
8977218-9	1997	We suggest that IL-4 and IL-13 may enhance iron uptake and storage in activated macrophages and thereby contribute to down-regulation of macrophage effector functions.	Iron	43-47	interleukin 13	Mus musculus	25-30
8978742-2	1997	Based on in vitro studies of the iron-containing monooxygenase tyrosine hydroxylase (TH), evidence is presented that this enzyme system may also contribute to such an oxidative stress.	Iron	33-37	tyrosine hydroxylase	Homo sapiens	63-83
8978742-2	1997	Based on in vitro studies of the iron-containing monooxygenase tyrosine hydroxylase (TH), evidence is presented that this enzyme system may also contribute to such an oxidative stress.	Iron	33-37	tyrosine hydroxylase	Homo sapiens	85-87
9106153-0	1997	In vivo ESR-CT imaging of the liver in mice receiving subcutaneous injection of nitric oxide-bound iron complex.	Iron	99-103	esterase 5 regulator	Mus musculus	8-11
9106153-2	1997	The use of NO-bound iron complex with N-(dithiocarboxy)sarcosine resulted in a clear ESR-CT image showing high intensity areas in the ventral regions, while other NO-bound iron complexes with N-methyl-D-glucamine dithiocarbamate or N,N-diethyl-dithiocarbamate were inappropriate because of low S/N ratios.	Iron	20-24	esterase 5 regulator	Mus musculus	85-88
9046019-0	1997	NADPH-initiated cytochrome P450-dependent free iron-independent microsomal lipid peroxidation: specific prevention by ascorbic acid.	Iron	47-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-31
9266623-0	1997	Availability of iron and degree of inflammation modifies the response to recombinant human erythropoietin when treating anemia of chronic disease in patients with rheumatoid arthritis.	Iron	16-20	erythropoietin	Homo sapiens	91-105
8955081-2	1996	Reaction of H2O2 with ferric leghemoglobin (metLb, the monomeric, oxygen-carrying, heme protein from root nodules of nitrogen-fixing plants) has been previously shown to generate an iron(IV)-oxo (ferryl) species and at least one protein radical.	Iron	182-186	leghemoglobin A	Glycine max	29-42
8955135-8	1996	Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES.	Iron	55-58	growth factor receptor bound protein 2	Homo sapiens	86-90
8955135-8	1996	Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES.	Iron	165-168	growth factor receptor bound protein 2	Homo sapiens	86-90
8989744-11	1996	When erythropoietin resistance is present, transferrin saturation of &lt; 27% or serum ferritin &lt; 300 ng/mL should be used to guide iron management.	Iron	135-139	erythropoietin	Homo sapiens	5-19
8989744-11	1996	When erythropoietin resistance is present, transferrin saturation of &lt; 27% or serum ferritin &lt; 300 ng/mL should be used to guide iron management.	Iron	135-139	transferrin	Homo sapiens	43-54
9195485-1	1996	The iron content in soybean lipoxygenase-1 is important for enzyme activity.	Iron	4-8	seed linoleate 13S-lipoxygenase-1	Glycine max	28-42
9004513-1	1996	Haemophilus influenzae acquires iron from the iron-transporting glycoprotein transferrin via a receptor-mediated process.	Iron	32-36	transferrin	Homo sapiens	77-88
8944032-1	1996	Hallervorden-Spatz syndrome (HSS) (OMIM #234200) is a rare, autosomal recessive neurode-generative disorder with brain iron accumulation as a prominent finding.	Iron	119-123	pantothenate kinase 2	Homo sapiens	29-32
8944032-8	1996	In order to gain insight into normal and abnormal brain iron transport, metabolism and function, our approach was to map the gene for HSS.	Iron	56-60	pantothenate kinase 2	Homo sapiens	134-137
8984578-3	1996	Laboratory investigation reveals significantly elevated serum ferritin and transferrin saturation with iron.	Iron	103-107	transferrin	Homo sapiens	75-86
9072885-0	1996	[Iron supplementation during erythropoietin therapy in patients on hemodialysis].	Iron	1-5	erythropoietin	Homo sapiens	29-43
9072885-2	1996	During its treatment by recombinant human erythropoietin (rHuEPO) erythropoiesis is accelerated and this increases demands on the supply of dietary erythropoietic precursors (Fe, pyridoxine, folic acid, vitamin B12).	Iron	175-177	erythropoietin	Homo sapiens	42-56
8904876-0	1996	Iron deprivation increases erythropoietin production in vitro, in normal subjects and patients with malignancy.	Iron	0-4	erythropoietin	Homo sapiens	27-41
8937451-1	1996	In mice, depression of hepatic uroporphyrinogen decarboxylase (UROD) leading to porphyrin accumulation (uroporphyria) occurs with chlorinated ligands of the aryl hydrocarbon (AH) receptor especially after iron overload.	Iron	205-209	aryl-hydrocarbon receptor	Mus musculus	157-187
8900380-7	1996	These results suggest that the increase of AVP excretion per remaining nephron could be a cause of the increase of FE(Na) in patients with renal failure.	Iron	115-117	arginine vasopressin	Homo sapiens	43-46
8920996-0	1996	Divergent effects of alpha 1-antitrypsin on the regulation of iron metabolism in human erythroleukaemic (K562) and myelomonocytic (THP-1) cells.	Iron	62-66	serpin family A member 1	Homo sapiens	21-40
8920996-0	1996	Divergent effects of alpha 1-antitrypsin on the regulation of iron metabolism in human erythroleukaemic (K562) and myelomonocytic (THP-1) cells.	Iron	62-66	GLI family zinc finger 2	Homo sapiens	131-136
8920996-2	1996	Here we demonstrate that in human erythroleukaemic cells (K562) alpha 1-AT enhances the binding affinity of iron-regulatory protein (IRP), the central regulator of cellular iron metabolism, to iron-responsive elements.	Iron	108-112	serpin family A member 1	Homo sapiens	64-74
8920996-2	1996	Here we demonstrate that in human erythroleukaemic cells (K562) alpha 1-AT enhances the binding affinity of iron-regulatory protein (IRP), the central regulator of cellular iron metabolism, to iron-responsive elements.	Iron	173-177	serpin family A member 1	Homo sapiens	64-74
8920996-4	1996	In agreement with the well-established mechanism of cellular iron regulation, alpha 1-AT seems to modulate trf-rec and ferritin expression primarily post-transcriptionally/translationally by influencing IRP activity.	Iron	61-65	serpin family A member 1	Homo sapiens	78-88
8920996-6	1996	Moreover the effects of alpha 1-AT on iron homeostasis in K562 cannot be overcome by the addition of iron salts, whereas concomitant treatment of THP-1 with iron and alpha 1-AT results in the same metabolic changes as the addition of iron alone.	Iron	38-42	serpin family A member 1	Homo sapiens	24-34
8920996-7	1996	Because alpha 1-AT blocks transferrin binding on K562 as well as on THP-1 cells, it is suggested, on the basis of the results presented here, (1) that erythroid and monocytic cells might differ in their dependence on transferrin-mediated iron supply and (2) that THP-1 might be able to acquire iron by a transferrin-independent iron uptake system.	Iron	238-242	serpin family A member 1	Homo sapiens	8-18
8920996-7	1996	Because alpha 1-AT blocks transferrin binding on K562 as well as on THP-1 cells, it is suggested, on the basis of the results presented here, (1) that erythroid and monocytic cells might differ in their dependence on transferrin-mediated iron supply and (2) that THP-1 might be able to acquire iron by a transferrin-independent iron uptake system.	Iron	294-298	serpin family A member 1	Homo sapiens	8-18
8920996-7	1996	Because alpha 1-AT blocks transferrin binding on K562 as well as on THP-1 cells, it is suggested, on the basis of the results presented here, (1) that erythroid and monocytic cells might differ in their dependence on transferrin-mediated iron supply and (2) that THP-1 might be able to acquire iron by a transferrin-independent iron uptake system.	Iron	294-298	serpin family A member 1	Homo sapiens	8-18
8920996-8	1996	alpha 1-AT might therefore be involved in the diversion of iron traffic between various cellular compartments under inflammatory conditions.	Iron	59-63	serpin family A member 1	Homo sapiens	0-10
8915458-0	1996	Effects of dietary iron loading with carbonyl iron and of iron depletion on intestinal growth, morphology, and expression of transferrin receptor in the rat.	Iron	19-23	transferrin	Rattus norvegicus	125-136
8904876-4	1996	Here we report that altered intracellular iron balance regulates EPO production both in vitro and in two unique clinical trials.	Iron	42-46	erythropoietin	Homo sapiens	65-68
8904876-5	1996	In vitro, both iron chelation with DFO and blockade of Tf-mediated iron uptake with anti-Tf receptor antibody 42/6, stimulated EPO production in serum-deprived hepatoma cells.	Iron	15-19	erythropoietin	Homo sapiens	127-130
8904876-5	1996	In vitro, both iron chelation with DFO and blockade of Tf-mediated iron uptake with anti-Tf receptor antibody 42/6, stimulated EPO production in serum-deprived hepatoma cells.	Iron	67-71	erythropoietin	Homo sapiens	127-130
8904876-6	1996	Conversely, iron repletion by haemin, inhibited EPO production in these cells.	Iron	12-16	erythropoietin	Homo sapiens	48-51
8904876-8	1996	These studies indicate intracellular iron balance regulates EPO production in humans.	Iron	37-41	erythropoietin	Homo sapiens	60-63
8985822-1	1996	Iron is transported in the blood plasma, mainly bound to transferrin, but in abnormal conditions other iron containing compounds may become important.	Iron	0-4	transferrin	Homo sapiens	57-68
8942403-0	1996	Chromatographic method for the determination of non-transferrin-bound iron suitable for use on the plasma and bronchoalveolar lavage fluid of preterm babies.	Iron	70-74	transferrin	Homo sapiens	52-63
8942403-4	1996	The modification of a method for the measurement of non-transferrin-bound iron in small volumes of plasma and bronchoalveolar lavage fluid from preterm babies is described.	Iron	74-78	transferrin	Homo sapiens	56-67
8942403-8	1996	Non-transferrin-bound iron was detected in 50% of plasma samples and 11% of bronchoalveolar lavage fluid samples collected over the first week of life from babies born prematurely.	Iron	22-26	transferrin	Homo sapiens	4-15
8985822-2	1996	These include ferritin, haemopexin-haem, haptoglobin-haemoglobin and non-specific non-transferrin-bound iron, all of which are taken up from the circulation by the liver.	Iron	104-108	transferrin	Homo sapiens	86-97
8985822-3	1996	Transferrin-bound iron can be used by all types of cells in amounts that depend on their complement of transferrin receptors.	Iron	18-22	transferrin	Homo sapiens	0-11
8985822-3	1996	Transferrin-bound iron can be used by all types of cells in amounts that depend on their complement of transferrin receptors.	Iron	18-22	transferrin	Homo sapiens	103-114
8985822-7	1996	It probably represents the mechanism by which iron derived from transferrin is transported into the cytosol after receptor-mediated endocytosis of the iron-transferrin complex.	Iron	46-50	transferrin	Homo sapiens	64-75
8985822-7	1996	It probably represents the mechanism by which iron derived from transferrin is transported into the cytosol after receptor-mediated endocytosis of the iron-transferrin complex.	Iron	46-50	transferrin	Homo sapiens	156-167
8985822-7	1996	It probably represents the mechanism by which iron derived from transferrin is transported into the cytosol after receptor-mediated endocytosis of the iron-transferrin complex.	Iron	151-155	transferrin	Homo sapiens	64-75
8985822-7	1996	It probably represents the mechanism by which iron derived from transferrin is transported into the cytosol after receptor-mediated endocytosis of the iron-transferrin complex.	Iron	151-155	transferrin	Homo sapiens	156-167
8985826-2	1996	Both major proteins of iron metabolism, ferritin and transferrin, are affected by alcohol.	Iron	23-27	transferrin	Homo sapiens	53-64
8914038-0	1996	A randomized controlled study of iron supplementation in patients treated with erythropoietin.	Iron	33-37	erythropoietin	Homo sapiens	79-93
8914038-1	1996	In view of current uncertainty regarding the optimum route for iron supplementation in patients receiving recombinant human erythropoietin (EPO), a prospective randomized controlled study was designed to investigate this issue.	Iron	63-67	erythropoietin	Homo sapiens	124-138
8914038-15	1996	iron have an enhanced hemoglobin response to EPO with better maintenance of iron stores and lower dosage requirements of EPO, compared with those patients receiving oral iron and no iron supplementation.	Iron	0-4	erythropoietin	Homo sapiens	45-48
8914038-15	1996	iron have an enhanced hemoglobin response to EPO with better maintenance of iron stores and lower dosage requirements of EPO, compared with those patients receiving oral iron and no iron supplementation.	Iron	0-4	erythropoietin	Homo sapiens	121-124
8914038-15	1996	iron have an enhanced hemoglobin response to EPO with better maintenance of iron stores and lower dosage requirements of EPO, compared with those patients receiving oral iron and no iron supplementation.	Iron	76-80	erythropoietin	Homo sapiens	45-48
8914038-15	1996	iron have an enhanced hemoglobin response to EPO with better maintenance of iron stores and lower dosage requirements of EPO, compared with those patients receiving oral iron and no iron supplementation.	Iron	76-80	erythropoietin	Homo sapiens	45-48
8914038-15	1996	iron have an enhanced hemoglobin response to EPO with better maintenance of iron stores and lower dosage requirements of EPO, compared with those patients receiving oral iron and no iron supplementation.	Iron	76-80	erythropoietin	Homo sapiens	45-48
8900411-5	1996	Taken together, these results demonstrate that the process of hexokinase inactivation induced by ascorbic acid/Fe(II) is mediated by dehydroascorbate and that iron and H202 have the sole function of accelerating its formation.	Iron	159-163	hexokinase-2	Oryctolagus cuniculus	62-72
8874221-1	1996	Iron delivery to mammalian cells is traditionally ascribed to diferric transferrin (Tf).	Iron	0-4	transferrin	Homo sapiens	71-82
8874221-1	1996	Iron delivery to mammalian cells is traditionally ascribed to diferric transferrin (Tf).	Iron	0-4	transferrin	Homo sapiens	84-86
8862458-2	1996	Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier.	Iron	159-163	transferrin	Homo sapiens	164-175
8917436-5	1996	One regulator of the transcriptional response to hypoxia has recently been identified as a heterodimeric DNA-binding complex termed hypoxia-inducible factor-1 (HIF-1), which is also inducible by the iron chelator, desferrioxamine.	Iron	199-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-158
8917436-5	1996	One regulator of the transcriptional response to hypoxia has recently been identified as a heterodimeric DNA-binding complex termed hypoxia-inducible factor-1 (HIF-1), which is also inducible by the iron chelator, desferrioxamine.	Iron	199-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-165
8917440-0	1996	Mossbauer, electron-paramagnetic-resonance and X-ray-absorption fine-structure studies of the iron environment in recombinant human tyrosine hydroxylase.	Iron	94-98	tyrosine hydroxylase	Homo sapiens	132-152
8917440-2	1996	Apo-human TH binds 1.0 atom Fe(II)/enzyme subunit, and iron binding is associated with an immediate and dramatic (40-fold) increase in specific activity.	Iron	55-59	tyrosine hydroxylase	Homo sapiens	10-12
8917440-5	1996	The addition of dopamine or H2O2 oxidizes the ferrous iron of the native human TH to the ferric state.	Iron	54-58	tyrosine hydroxylase	Homo sapiens	79-81
8897897-5	1996	SNAP caused increases in iron-responsive gene products, ferritin and mitochondrial aconitase, secondary to the release of iron from heme stores via HO induction, since these changes were also sensitive to SNPP.	Iron	25-29	aconitase 2	Homo sapiens	69-92
8923781-0	1996	Cord serum erythropoietin in 90 healthy newborn term infants: relationship to blood gases and iron status markers.	Iron	94-98	erythropoietin	Homo sapiens	11-25
8936961-11	1996	In summary, thalassemic children on long-term blood transfusion and iron chelation have progressive and early loss of B-cell mass, manifested by decreased insulin release in response to secretagogues, before the development of significant insulin resistance or impairment of glucose tolerance.	Iron	68-72	insulin	Homo sapiens	155-162
8923781-1	1996	In this study, we examined the cord serum erythropoietin (EPO) level in newborn infants in relation to venous cord blood gases and iron status markers (cord serum ferritin, cord serum transferrin saturation).	Iron	131-135	erythropoietin	Homo sapiens	42-56
8943756-4	1996	A bleomycin based assay was used to detect non-transferrin bound iron.	Iron	65-69	transferrin	Homo sapiens	47-58
8943756-9	1996	The remaining six patients had no obvious reason for raised AST activities, but four had non-transferrin bound iron detectable in their serum as compared with only two out of 28 patients with normal AST activities.	Iron	111-115	transferrin	Homo sapiens	93-104
8943756-12	1996	Non-transferrin bound iron may also be a more specific indicator of iron overload than the serum ferritin concentrations.	Iron	22-26	transferrin	Homo sapiens	4-15
8943756-12	1996	Non-transferrin bound iron may also be a more specific indicator of iron overload than the serum ferritin concentrations.	Iron	68-72	transferrin	Homo sapiens	4-15
8823311-1	1996	Iron is bound to transferrin in the plasma.	Iron	0-4	transferrin	Homo sapiens	17-28
8798666-0	1996	Identification of a conserved and functional iron-responsive element in the 5"-untranslated region of mammalian mitochondrial aconitase.	Iron	45-49	aconitase 2	Homo sapiens	112-135
8798666-2	1996	When cells are iron-depleted, iron regulatory proteins (IRPs) bind to IREs in the transcripts of ferritin, transferrin receptor, and erythroid amino-levulinic acid synthetase.	Iron	15-19	transferrin	Homo sapiens	107-118
8798666-2	1996	When cells are iron-depleted, iron regulatory proteins (IRPs) bind to IREs in the transcripts of ferritin, transferrin receptor, and erythroid amino-levulinic acid synthetase.	Iron	30-34	transferrin	Homo sapiens	107-118
8798666-7	1996	Furthermore, levels of mitochondrial aconitase are decreased in mice maintained on a low iron diet, whereas levels of mRNA remain unchanged.	Iron	89-93	aconitase 2	Homo sapiens	23-46
8798666-9	1996	Thus, expression of the iron-sulfur protein mitochondrial aconitase and function of the citric acid cycle may be regulated by iron levels in cells.	Iron	24-28	aconitase 2	Homo sapiens	44-67
8914434-6	1996	The mechanism of insulin resistance, produced by iron overload, remains unknown.	Iron	49-53	insulin	Homo sapiens	17-24
8905632-7	1996	EDTA also binds to LPO-CN-complex indicating its binding site away from heme iron centre.	Iron	77-81	lactoperoxidase	Homo sapiens	19-22
8823311-2	1996	A specific receptor on the cell surface binds transferrin and internalizes transferrin and the iron in clathrin-coated pits.	Iron	95-99	transferrin	Homo sapiens	46-57
8823311-5	1996	This article shows that the two pathways donate iron to mobilferrin which acts as an intermediate between the iron bound to transferrin and the incorporation of iron into hemoglobin.	Iron	48-52	transferrin	Homo sapiens	124-135
8823311-5	1996	This article shows that the two pathways donate iron to mobilferrin which acts as an intermediate between the iron bound to transferrin and the incorporation of iron into hemoglobin.	Iron	110-114	transferrin	Homo sapiens	124-135
8823311-5	1996	This article shows that the two pathways donate iron to mobilferrin which acts as an intermediate between the iron bound to transferrin and the incorporation of iron into hemoglobin.	Iron	110-114	transferrin	Homo sapiens	124-135
8823311-6	1996	Mobilferrin is found associated with the transferrin containing vesicles, and becomes labeled with iron released from transferrin in the vesicles.	Iron	99-103	transferrin	Homo sapiens	118-129
8805663-3	1996	Using a subtraction cloning strategy, we identified a rat isoform of the complement C4 protein gene whose expression was strongly induced in stellate cells after iron overload.	Iron	162-166	complement C4A	Rattus norvegicus	73-86
8828436-1	1996	OBJECTIVE: The concerted iron-binding antioxidant activity of transferrin and ceruloplasmin decreases with increasing transferrin saturation by iron.	Iron	25-29	transferrin	Homo sapiens	62-73
8806657-2	1996	In the inherited disease haemochromatotis (HC) progressive iron loading of the parenchymal cells (hepatocytes) of the liver leads to cellular toxicity.	Iron	59-63	SRR1 domain containing	Homo sapiens	43-45
11666741-8	1996	The oxidation with [Co(dipic)(2)](-) has no [H(+)] dependence, [H(+)] = 0.50-2.00 M. With Fe(III) as oxidant, reaction steps involving [Fe(H(2)O)(6)](3+) and [Fe(H(2)O)(5)OH](2+) are implicated.	Iron	90-92	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	93-96
11666741-8	1996	The oxidation with [Co(dipic)(2)](-) has no [H(+)] dependence, [H(+)] = 0.50-2.00 M. With Fe(III) as oxidant, reaction steps involving [Fe(H(2)O)(6)](3+) and [Fe(H(2)O)(5)OH](2+) are implicated.	Iron	136-138	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	93-96
8828436-1	1996	OBJECTIVE: The concerted iron-binding antioxidant activity of transferrin and ceruloplasmin decreases with increasing transferrin saturation by iron.	Iron	25-29	transferrin	Homo sapiens	118-129
8828436-1	1996	OBJECTIVE: The concerted iron-binding antioxidant activity of transferrin and ceruloplasmin decreases with increasing transferrin saturation by iron.	Iron	144-148	transferrin	Homo sapiens	62-73
8828436-1	1996	OBJECTIVE: The concerted iron-binding antioxidant activity of transferrin and ceruloplasmin decreases with increasing transferrin saturation by iron.	Iron	144-148	transferrin	Homo sapiens	118-129
8828436-3	1996	We also asked if the release of iron from free hemoglobin by lipid hydroperoxides is a potential mechanism to increase transferrin saturation in preeclampsia.	Iron	32-36	transferrin	Homo sapiens	119-130
8892536-0	1996	Carbohydrate-deficient transferrin in healthy women: relation to estrogens and iron status.	Iron	79-83	transferrin	Homo sapiens	23-34
8828436-12	1996	Electron paramagnetic resonance spectroscopy demonstrated that the release of iron from free hemoglobin by lipid hydroperoxides in serum is a potential mechanism to increase transferrin saturation.	Iron	78-82	transferrin	Homo sapiens	174-185
8828436-13	1996	CONCLUSION: Increased transferrin saturation and decreased unsaturated iron-binding capacity in preeclampsia may occur consequent to oxidative stress and then further promote oxidative stress by decreasing serum antioxidant buffering against redox-active iron.	Iron	255-259	transferrin	Homo sapiens	22-33
8751951-0	1996	Outer membrane protein B1, an iron-repressible protein conserved in the outer membrane of Moraxella (Branhamella) catarrhalis, binds human transferrin.	Iron	30-34	transferrin	Homo sapiens	139-150
8831290-1	1996	Iron uptake and storage in mammalian cells is at least partly regulated at a post-transcriptional level by the iron regulatory proteins (IRP-1 and IRP-2).	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	147-152
8831290-1	1996	Iron uptake and storage in mammalian cells is at least partly regulated at a post-transcriptional level by the iron regulatory proteins (IRP-1 and IRP-2).	Iron	111-115	iron responsive element binding protein 2	Homo sapiens	147-152
8831290-6	1996	They are coordinately regulated by cellular iron, but whereas IRP-1 is inactivated by high iron levels, IRP-2 is rapidly degraded.	Iron	44-48	iron responsive element binding protein 2	Homo sapiens	104-109
8831290-9	1996	These findings hint that IRP-1 and IRP-2 may bind preferentially to certain mRNAs in vivo, possibly extending their known functions beyond the regulation of intracellular iron homeostasis.	Iron	171-175	iron responsive element binding protein 2	Homo sapiens	35-40
8836047-2	1996	When iron is scarce, IRP binds to IRE and coordinately increases the synthesis of transferrin receptor and decreases that of ferritin, thus providing the cell with readily available free iron.	Iron	5-9	transferrin	Homo sapiens	82-93
8889603-0	1996	Intermediate steps in cellular iron uptake from transferrin.	Iron	31-35	transferrin	Homo sapiens	48-59
8889603-3	1996	A previous study described a cytoplasmic, transferrin (Tf)-free, iron (Fe) pool that was detected only when cells were mechanically detached from the culture substratum at 4 degrees C, after initial incubation with 59Fe-125I-Tf at 37 degrees C (Richardson and Baker, 1992a).	Iron	65-69	transferrin	Homo sapiens	42-53
8889033-1	1996	We have reported that di-n-butyl phthalate (DBP) caused the depletion of circulating iron, characterized by the release of iron from both haemoglobin (Hb) and transferrin (Tf).	Iron	85-89	transferrin	Rattus norvegicus	159-170
8889033-1	1996	We have reported that di-n-butyl phthalate (DBP) caused the depletion of circulating iron, characterized by the release of iron from both haemoglobin (Hb) and transferrin (Tf).	Iron	85-89	transferrin	Rattus norvegicus	172-174
8889033-1	1996	We have reported that di-n-butyl phthalate (DBP) caused the depletion of circulating iron, characterized by the release of iron from both haemoglobin (Hb) and transferrin (Tf).	Iron	123-127	transferrin	Rattus norvegicus	159-170
8889033-1	1996	We have reported that di-n-butyl phthalate (DBP) caused the depletion of circulating iron, characterized by the release of iron from both haemoglobin (Hb) and transferrin (Tf).	Iron	123-127	transferrin	Rattus norvegicus	172-174
8889033-3	1996	In the in vivo study, there were observed depletions of Hb in the blood and of iron in the hepatic Tf fraction, as well as an accumulation of iron in the hepatic hemosiderin (Hs) and splenic Tf fractions.	Iron	79-83	transferrin	Rattus norvegicus	99-101
8889033-4	1996	In the in vitro study, mono-butyl phthalate (MBP), a metabolite of DBP, caused a depletion of iron in the plasma Tf, although a direct release of iron from Tf was not detectable.	Iron	94-98	transferrin	Rattus norvegicus	113-115
8889033-4	1996	In the in vitro study, mono-butyl phthalate (MBP), a metabolite of DBP, caused a depletion of iron in the plasma Tf, although a direct release of iron from Tf was not detectable.	Iron	146-150	transferrin	Rattus norvegicus	156-158
8889603-3	1996	A previous study described a cytoplasmic, transferrin (Tf)-free, iron (Fe) pool that was detected only when cells were mechanically detached from the culture substratum at 4 degrees C, after initial incubation with 59Fe-125I-Tf at 37 degrees C (Richardson and Baker, 1992a).	Iron	65-69	transferrin	Homo sapiens	55-57
8889603-3	1996	A previous study described a cytoplasmic, transferrin (Tf)-free, iron (Fe) pool that was detected only when cells were mechanically detached from the culture substratum at 4 degrees C, after initial incubation with 59Fe-125I-Tf at 37 degrees C (Richardson and Baker, 1992a).	Iron	71-73	transferrin	Homo sapiens	42-53
8889603-3	1996	A previous study described a cytoplasmic, transferrin (Tf)-free, iron (Fe) pool that was detected only when cells were mechanically detached from the culture substratum at 4 degrees C, after initial incubation with 59Fe-125I-Tf at 37 degrees C (Richardson and Baker, 1992a).	Iron	71-73	transferrin	Homo sapiens	55-57
8918624-2	1996	In the years prior to the use of human recombinant erythropoietin (rHuEpo), patients undergoing haemodialysis were subjected to an excessive iron load as a consequence of frequent blood transfusions.	Iron	141-145	erythropoietin	Homo sapiens	51-65
9174967-1	1996	Vertebrate transferrin is a well characterized iron transport protein.	Iron	47-51	transferrin	Homo sapiens	11-22
8814203-0	1996	Intestinal epithelia (Caco-2) cells acquire iron through the basolateral endocytosis of transferrin.	Iron	44-48	transferrin	Homo sapiens	88-99
8814203-2	1996	Polarized enterocytes have transferrin receptors in their basolateral surface; hence, we tested the hypothesis that the endocytosis of circulating transferrin may be part of the body"s iron sensing mechanism.	Iron	185-189	transferrin	Homo sapiens	147-158
8814203-5	1996	When the cells were simultaneously offered equimolar amounts of iron, from the apical medium as 55Fe-nitrilotriacetate and from the basolateral medium as 59Fe-transferrin, most of the internalized iron came from the basolateral endocytosis of 59Fe-transferrin.	Iron	197-201	transferrin	Homo sapiens	159-170
8814203-9	1996	Caco-2 cells, but not K562 cells, showed inhibition of basolateral, transferrin-mediated iron uptake by apotransferrin.	Iron	89-93	transferrin	Homo sapiens	68-79
8814203-11	1996	We propose that the basolateral endocytosis of transferrin forms part of the system by which intestinal epithelia cells sense plasma iron concentrations.	Iron	133-137	transferrin	Homo sapiens	47-58
8885271-0	1996	Exotoxin A production in Pseudomonas aeruginosa requires the iron-regulated pvdS gene encoding an alternative sigma factor.	Iron	61-65	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	76-80
8885271-4	1996	Evidence is presented that the iron control of ETA synthesis is mediated by a Fur-regulated alternative sigma factor, PvdS, which had initially been identified as a positive activator for the production of the siderophore pyoverdin.	Iron	31-35	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	118-122
8885271-5	1996	In a delta pvdS deletion mutant, ETA was produced at low levels of less than 5% compared to wild type, but still in response to iron starvation, and introduction of a functional pvdS gene on a plasmid fully restored wild-type levels and normal iron regulation of ETA synthesis.	Iron	128-132	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	11-15
8885271-5	1996	In a delta pvdS deletion mutant, ETA was produced at low levels of less than 5% compared to wild type, but still in response to iron starvation, and introduction of a functional pvdS gene on a plasmid fully restored wild-type levels and normal iron regulation of ETA synthesis.	Iron	244-248	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	178-182
8885271-8	1996	Overexpression of pvdS from the tac promoter on a plasmid resulted in a high-level and iron-independent production of ETA in wild-type PAO1, in the delta pvdS strain, but not in a delta regA strain as a host.	Iron	87-91	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	18-22
8918625-10	1996	Iron "oversaturation" of transferrin iron binding did not occur in patients with transferrin levels &gt; 180 mg/dl.	Iron	0-4	transferrin	Homo sapiens	25-36
8885271-10	1996	The transcription of regAB and toxA after induction of the P tac-pvdS gene was monitored in cells grown in high-iron medium.	Iron	112-116	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	65-69
8885271-12	1996	These results suggest that a second regulatory mechanism besides the Fur-PvdS system is involved in iron regulation of ETA production.	Iron	100-104	extracytoplasmic-function sigma-70 factor	Pseudomonas aeruginosa PAO1	73-77
8918625-10	1996	Iron "oversaturation" of transferrin iron binding did not occur in patients with transferrin levels &gt; 180 mg/dl.	Iron	37-41	transferrin	Homo sapiens	25-36
8865272-3	1996	We hypothesized that administration of erythropoietin (EPO) mobilizes iron from plasma and inhibits iron-catalyzed reactions.	Iron	70-74	erythropoietin	Homo sapiens	39-53
8761454-7	1996	Increased AtFer1 transcript abundance in response to iron is inhibited by the antioxidant N-acetylcysteine.	Iron	53-57	ferretin 1	Arabidopsis thaliana	10-16
8865272-3	1996	We hypothesized that administration of erythropoietin (EPO) mobilizes iron from plasma and inhibits iron-catalyzed reactions.	Iron	70-74	erythropoietin	Homo sapiens	55-58
8865272-3	1996	We hypothesized that administration of erythropoietin (EPO) mobilizes iron from plasma and inhibits iron-catalyzed reactions.	Iron	100-104	erythropoietin	Homo sapiens	39-53
8865272-3	1996	We hypothesized that administration of erythropoietin (EPO) mobilizes iron from plasma and inhibits iron-catalyzed reactions.	Iron	100-104	erythropoietin	Homo sapiens	55-58
8831423-6	1996	Iron, an important element in hemoglobin synthesis, is bound to the iron transport protein transferrin, and the complex is internalized, along with the transferrin receptor, by the developing erythroid cell.	Iron	0-4	transferrin	Homo sapiens	91-102
8831423-6	1996	Iron, an important element in hemoglobin synthesis, is bound to the iron transport protein transferrin, and the complex is internalized, along with the transferrin receptor, by the developing erythroid cell.	Iron	0-4	transferrin	Homo sapiens	152-163
8831423-6	1996	Iron, an important element in hemoglobin synthesis, is bound to the iron transport protein transferrin, and the complex is internalized, along with the transferrin receptor, by the developing erythroid cell.	Iron	68-72	transferrin	Homo sapiens	91-102
8831423-8	1996	Administration of recombinant human erythropoietin induces changes in iron metabolism, which are reflected by decreases in both the serum iron level and transferrin saturation.	Iron	70-74	erythropoietin	Homo sapiens	36-50
8831423-8	1996	Administration of recombinant human erythropoietin induces changes in iron metabolism, which are reflected by decreases in both the serum iron level and transferrin saturation.	Iron	70-74	transferrin	Homo sapiens	153-164
8831423-8	1996	Administration of recombinant human erythropoietin induces changes in iron metabolism, which are reflected by decreases in both the serum iron level and transferrin saturation.	Iron	138-142	erythropoietin	Homo sapiens	36-50
8718890-9	1996	A model is presented for a prereaction complex of myeloperoxidase in which hydrogen peroxide is hydrogen bonded to the distal histidine, as a prerequisite for deprotonation and subsequent binding at the sixth coordination site of the heme iron.	Iron	239-243	myeloperoxidase	Homo sapiens	50-65
8764564-0	1996	In vitro tumor growth inhibition by bispecific antibodies to human transferrin receptor and tumor-associated antigens is augmented by the iron chelator deferoxamine.	Iron	138-142	transferrin	Homo sapiens	67-78
8706019-0	1996	Up-regulation of vascular endothelial growth factor production by iron chelators.	Iron	66-70	vascular endothelial growth factor A	Homo sapiens	17-51
8706019-7	1996	A panel of structurally different iron chelators induced an even more potent increase in VEGF mRNA expression.	Iron	34-38	vascular endothelial growth factor A	Homo sapiens	89-93
8706019-9	1996	These findings suggest that VEGF may act as a mediator of the side effects induced by iron chelation therapy.	Iron	86-90	vascular endothelial growth factor A	Homo sapiens	28-32
8706019-10	1996	In addition, because VEGF is an important regulator of angiogenesis, iron chelators should be given with caution to cancer patients.	Iron	69-73	vascular endothelial growth factor A	Homo sapiens	21-25
8710843-3	1996	Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs).	Iron	38-42	iron responsive element binding protein 2	Homo sapiens	76-81
8710843-3	1996	Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs).	Iron	114-118	iron responsive element binding protein 2	Homo sapiens	76-81
8992416-8	1996	(4) Glucocortocoid replacement therapy in a patient with neurofibromatosis type 1 resulted in a complete normalization of both secondary adrenal insufficiency and a previously unexplained iron-refractor iron-deficient anemia.	Iron	188-192	neurofibromin 1	Homo sapiens	57-81
8806716-11	1996	The inhibition of the ferritin-catalyzed lipid peroxidation by superoxide dismutase and anti-CYP2E1 IgG is consistent with a role for CYP2E1-generated superoxide radical in mobilizing iron from ferritin and in the subsequent catalysis of lipid peroxidation.	Iron	184-188	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	93-99
8806716-11	1996	The inhibition of the ferritin-catalyzed lipid peroxidation by superoxide dismutase and anti-CYP2E1 IgG is consistent with a role for CYP2E1-generated superoxide radical in mobilizing iron from ferritin and in the subsequent catalysis of lipid peroxidation.	Iron	184-188	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	134-140
8806716-12	1996	Since ferritin is the major cellular storage form of iron, increased mobilization of iron from ferritin by CYP2E1-derived superoxide radical may play a role in the development of oxidative stress after ethanol treatment.	Iron	53-57	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	107-113
8806716-12	1996	Since ferritin is the major cellular storage form of iron, increased mobilization of iron from ferritin by CYP2E1-derived superoxide radical may play a role in the development of oxidative stress after ethanol treatment.	Iron	85-89	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	107-113
24194250-0	1996	Transferrin mRNA in relation to liver iron storage in farmed Atlantic salmonSalmo salar.	Iron	38-42	serotransferrin-1	Salmo salar	0-11
8764614-1	1996	Iron regulatory proteins (IRPs) are cytoplasmic RNA binding proteins that regulate expression of ferritin, erythroid 5-aminolevulinic acid synthase, and transferrin receptor through interaction with conserved RNA stem-loop structures called iron-responsive elements (IREs).	Iron	241-245	transferrin	Homo sapiens	153-164
8708785-3	1996	The increased need for iron has been used as a method to target tumors and there is well-documented evidence that certain tumors can be imaged with tracers such as 67Ga, that mimic transferrin-mediated iron uptake.	Iron	202-206	transferrin	Homo sapiens	181-192
8708785-5	1996	METHODS: We measured the binding affinities of [18F]diferric (holo-) and iron-free (apo-) transferrin on two human cell lines.	Iron	73-77	transferrin	Homo sapiens	90-101
8765624-0	1996	A comparison of oral and intravenous iron supplementation in preterm infants receiving recombinant erythropoietin.	Iron	37-41	erythropoietin	Homo sapiens	99-113
8858521-2	1996	Cellular iron uptake is mediated by transferrin receptors.	Iron	9-13	transferrin	Homo sapiens	36-47
8765624-1	1996	OBJECTIVE: To determine whether intravenously administered iron supplements would improve the hematologic response to recombinant erythropoietin in stable preterm infants.	Iron	59-63	erythropoietin	Homo sapiens	130-144
8806853-7	1996	After 24 hr treatment with the chelators, a large portion of the available transferrin receptors moved to the cell surface, indicating that the cells were iron-starved.	Iron	155-159	transferrin	Homo sapiens	75-86
8660692-2	1996	The active-site topology of CYP2D6 is examined here with phenyl-, 2-naphthyl-, and p-biphenyldiazene, which react with P450 enzymes to form sigma-bonded aryl-iron (Fe-Ar) complexes.	Iron	158-162	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	28-34
15299626-2	1996	The DOT structure, which contains two iron binding sites, is similar to the known transferrin and lactoferrin structures.	Iron	38-42	transferrin	Homo sapiens	82-93
8659486-7	1996	Transferrin saturation (serum iron concentration divided by total iron binding capacity) was used as a measure of the amount of circulating iron available to tissues.	Iron	30-34	transferrin	Homo sapiens	0-11
8806853-6	1996	These effects were antagonized by the addition of iron as ferrous sulfate (250 microM), which is bound to transferrin and imported into the cell via transferrin receptor endocytosis, or as hemin (100 microM), which passes through the cell membrane and releases iron into the cytosol.	Iron	50-54	transferrin	Homo sapiens	106-117
8806853-6	1996	These effects were antagonized by the addition of iron as ferrous sulfate (250 microM), which is bound to transferrin and imported into the cell via transferrin receptor endocytosis, or as hemin (100 microM), which passes through the cell membrane and releases iron into the cytosol.	Iron	50-54	transferrin	Homo sapiens	149-160
8695819-0	1996	Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy.	Iron	69-73	transferrin	Homo sapiens	44-55
8695819-1	1996	The rapidity and duration of the response of non-transferrin-bound iron (NTBPI) to chelation therapy are largely unknown and have important implications for the design of optimal chelation regimens.	Iron	67-71	transferrin	Homo sapiens	49-60
8660692-2	1996	The active-site topology of CYP2D6 is examined here with phenyl-, 2-naphthyl-, and p-biphenyldiazene, which react with P450 enzymes to form sigma-bonded aryl-iron (Fe-Ar) complexes.	Iron	164-166	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	28-34
9035730-1	1996	Coinjection of citrate iron complex (7.5-10 mg iron/kg) with Escherichia coli lipopolysaccharide (LPS) inhibited generation of nitric oxide in the liver of mice caused by LPS-dependent synthesis of inducible NO-synthase (iNOS).	Iron	23-27	nitric oxide synthase 2, inducible	Mus musculus	198-219
8804590-1	1996	We performed hole-burning Stark effect experiments on cytochrome c in which the iron of the herne was either removed or replaced by Zn.	Iron	80-84	cytochrome c, somatic	Homo sapiens	54-66
9035730-1	1996	Coinjection of citrate iron complex (7.5-10 mg iron/kg) with Escherichia coli lipopolysaccharide (LPS) inhibited generation of nitric oxide in the liver of mice caused by LPS-dependent synthesis of inducible NO-synthase (iNOS).	Iron	23-27	nitric oxide synthase 2, inducible	Mus musculus	221-225
8690793-6	1996	Administration of DTPA iron (III) did not alter mean systemic arterial pressure, but did protect baboons in the presence of high levels of TNF-alpha and free radical overproduction.	Iron	23-27	tumor necrosis factor	Mus musculus	139-148
8647924-2	1996	Among the circulatory proteins that protect against iron-catalyzed production of free radicals are apo-transferrin, which binds ferric iron and has previously been shown to be made by cells of the neural retina (Davis and Hunt, 1993, J.	Iron	52-56	transferrin	Homo sapiens	103-114
8647926-4	1996	In 51Cr release assays, the toxicity of exogenous RO2S including hydrogen peroxide or superoxide (generated by xanthine oxidase/hypoxanthine) to human retinal pigment epithelial cells was inhibited by the iron chelators, desferrioxamine and apo-transferrin.	Iron	205-209	transferrin	Homo sapiens	245-256
8647926-8	1996	It is concluded, first, that toxic effects of iron and heme can be prevented by apo-transferrin or apo-hemopexin and, second, that exposure of RPE cells to free heme or hemopexin sets in motion a series of biochemical events resulting in protection against oxidative stress.	Iron	46-50	transferrin	Homo sapiens	84-95
10887502-1	1996	Lactoferrin is an iron-binding glycoprotein of the transferrin family, first isolated from milk but also found in most exocrine secretions as well as in the secondary granules of neutrophils.	Iron	18-22	transferrin	Homo sapiens	51-62
8843437-3	1996	In an iron-deficient medium, the presence of a plasmid carrying ptxR in P. aeruginosa PAO1 resulted in a four-to fivefold increase in exotoxin A synthesis.	Iron	6-10	HTH-type transcriptional regulator PtxR	Pseudomonas aeruginosa PAO1	64-68
8843544-6	1996	Immediately after separation, electron microscopy revealed that the CD34+ selected fraction contained more than 45% of well-differentiated myeloid cells (MPO+), with iron beads preferentially clustered at one pole of the cell surface and sometimes already endocytosed in pinocytic vesicles.	Iron	166-170	CD34 molecule	Homo sapiens	68-72
8660592-0	1996	Resolution of all four transferrin isoforms produced during the iron binding process using multizone electrophoresis.	Iron	64-68	transferrin	Homo sapiens	23-34
8660825-2	1996	In the present study, we evaluated the influence of iron loading on the constitutive and interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS)-induced functional and secretory properties of microglial cells, using the in vitro established murine cell line BV-2.	Iron	52-56	interferon gamma	Mus musculus	89-105
8660825-2	1996	In the present study, we evaluated the influence of iron loading on the constitutive and interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS)-induced functional and secretory properties of microglial cells, using the in vitro established murine cell line BV-2.	Iron	52-56	interferon gamma	Mus musculus	107-116
8660825-3	1996	We demonstrate that iron augments the basal and IFN-gamma plus LPS-enhanced anti-Candida albicans activity exerted by BV-2 cells and that the phenomenon occurs with no enhancement of phagocytic activity.	Iron	20-24	interferon gamma	Mus musculus	48-57
8660825-4	1996	Furthermore, when the secretory properties of IFN-gamma plus LPS-treated BV-2 cells were assessed, we found that tumor necrosis factor remains unchanged while nitric oxide production is significantly reduced in iron-loaded cells.	Iron	211-215	interferon gamma	Mus musculus	46-55
8660825-4	1996	Furthermore, when the secretory properties of IFN-gamma plus LPS-treated BV-2 cells were assessed, we found that tumor necrosis factor remains unchanged while nitric oxide production is significantly reduced in iron-loaded cells.	Iron	211-215	tumor necrosis factor	Mus musculus	113-134
8809846-1	1996	Transferrin is the major protein concerned with iron transport in the serum and may provide a route by which iron enters the brain.	Iron	48-52	transferrin	Homo sapiens	0-11
8815424-0	1996	Supervised intradialytic oral iron administration during erythropoietin therapy.	Iron	30-34	erythropoietin	Homo sapiens	57-71
8809846-1	1996	Transferrin is the major protein concerned with iron transport in the serum and may provide a route by which iron enters the brain.	Iron	109-113	transferrin	Homo sapiens	0-11
8809846-5	1996	Therefore transferrin receptor density shows a mismatch with the known distribution of iron in the human brain.	Iron	87-91	transferrin	Homo sapiens	10-21
8639855-12	1996	A true body-iron deficiency caused by decreased iron absorption likely complicates long-lasting inflammation in the most anemic children, and this can be recognized by high serum transferrin receptor levels.	Iron	12-16	transferrin	Homo sapiens	179-190
8660366-1	1996	Both in vivo and in Hep3B cells, expression of the erythropoietin gene is induced by hypoxia as well as by certain transition metals (cobalt and nickel) and by iron chelation.	Iron	160-164	erythropoietin	Homo sapiens	51-65
8660366-2	1996	When Hep3B cells were incubated in an iron deficient medium, Epo mRNA expression was enhanced 4-fold compared to Hep3B cells in iron enriched medium.	Iron	38-42	erythropoietin	Homo sapiens	61-64
8660366-3	1996	The increased Epo expression in iron deficient medium was abolished when Fe2-transferrin complex was added.	Iron	32-36	erythropoietin	Homo sapiens	14-17
8660366-4	1996	Epo induction by cobalt was also affected by iron concentration.	Iron	45-49	erythropoietin	Homo sapiens	0-3
8660366-5	1996	In iron enriched medium, erythropoietin expression in Hep3B cells was maximally induced at CoCl2 concentrations between 100 to 200 microM.	Iron	3-7	erythropoietin	Homo sapiens	25-39
8716991-13	1996	CONCLUSIONS: This analysis found the use of iron dextran in the hemodialysis setting to be an effective and economic means to maintain hematocrit values and iron availability while optimizing erythropoietin dosing.	Iron	44-48	erythropoietin	Homo sapiens	192-206
8639855-10	1996	In 10 severely anemic patients, amelioration of anemia following intravenous iron administration resulted in normalization of serum transferrin receptor.	Iron	77-81	transferrin	Homo sapiens	132-143
8662826-2	1996	Isolated plasma membranes were enriched in the product of the FRE1 gene and had NADPH dehydrogenase activity that was increased when the cells were grown in iron/copper-deprived medium.	Iron	157-161	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	62-66
8651239-9	1996	Specific proteins that have been shown to be cytotoxic are transferrin/iron, low-density lipoprotein, and complement components, all of which appear in the urine in proteinuric states.	Iron	71-75	transferrin	Homo sapiens	59-70
8767353-5	1996	The compartment model used includes a Michaelis-Menten term and is in excellent agreement with the observed exchange of iron to transferrin and with the daily iron turnover by transferrin.	Iron	120-124	transferrin	Homo sapiens	128-139
8767353-5	1996	The compartment model used includes a Michaelis-Menten term and is in excellent agreement with the observed exchange of iron to transferrin and with the daily iron turnover by transferrin.	Iron	159-163	transferrin	Homo sapiens	176-187
8767353-10	1996	The calculated amount of iron transported by transferrin was 31.0 +/- 6.6 mg Fe/ 24h.	Iron	25-29	transferrin	Homo sapiens	45-56
8703813-4	1996	The serum non-transferrin bound iron (NTBI) levels fell significantly in both groups within 12h of commencing the continuous infusion.	Iron	32-36	transferrin	Homo sapiens	14-25
8639855-14	1996	Thus, while chronically high endogenous IL-6 levels do not appear to blunt epo production, they are probably responsible for the observed abnormalities in iron metabolism.	Iron	155-159	interleukin 6	Homo sapiens	40-44
8681959-0	1996	Effects of overexpression of the transferrin receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron.	Iron	128-132	transferrin	Homo sapiens	33-44
8740506-2	1996	CONCLUSIONS: Two key iron-related proteins in the human body are ferritin which is the iron storage protein, and the transferrin receptor, which controls the entry of iron-bearing transferrin to cells.	Iron	21-25	transferrin	Homo sapiens	117-128
8740506-2	1996	CONCLUSIONS: Two key iron-related proteins in the human body are ferritin which is the iron storage protein, and the transferrin receptor, which controls the entry of iron-bearing transferrin to cells.	Iron	21-25	transferrin	Homo sapiens	180-191
8740506-2	1996	CONCLUSIONS: Two key iron-related proteins in the human body are ferritin which is the iron storage protein, and the transferrin receptor, which controls the entry of iron-bearing transferrin to cells.	Iron	87-91	transferrin	Homo sapiens	117-128
8740506-2	1996	CONCLUSIONS: Two key iron-related proteins in the human body are ferritin which is the iron storage protein, and the transferrin receptor, which controls the entry of iron-bearing transferrin to cells.	Iron	87-91	transferrin	Homo sapiens	180-191
8740506-2	1996	CONCLUSIONS: Two key iron-related proteins in the human body are ferritin which is the iron storage protein, and the transferrin receptor, which controls the entry of iron-bearing transferrin to cells.	Iron	87-91	transferrin	Homo sapiens	117-128
8740506-2	1996	CONCLUSIONS: Two key iron-related proteins in the human body are ferritin which is the iron storage protein, and the transferrin receptor, which controls the entry of iron-bearing transferrin to cells.	Iron	87-91	transferrin	Homo sapiens	180-191
8740506-6	1996	Increases in serum ferritin reflect increased storage iron and increases in serum transferrin receptor reflect cellular iron deficits.	Iron	120-124	transferrin	Homo sapiens	82-93
9816262-2	1996	Transferrin, the iron transport protein, increases gallium uptake by cells, whereas pyridoxal isonicotinoyl hydrazone (PIH), an iron chelator, transports iron into cells.	Iron	17-21	transferrin	Homo sapiens	0-11
8681959-2	1996	The uptake of transferrin-bound Fe and non-transferrin-bound Fe(II), and the surface binding, endocytosis and recycling of transferrin were measured.	Iron	32-34	transferrin	Homo sapiens	14-25
8681959-3	1996	In cells that expressed increasing numbers of surface transferrin receptors, the rate of Fe uptake increased at a slower rate than the number of receptors.	Iron	89-91	transferrin	Homo sapiens	54-65
8681959-5	1996	Hence, a restricted recycling rate of the transferrin receptor appeared to be responsible for the slower rate of Fe uptake by cells with high receptor numbers, presumably because one or more cytosolic components required for recycling were in limited supply.	Iron	113-115	transferrin	Homo sapiens	42-53
8776576-8	1996	Consistent with the expression of H-ferritin is the expression of transferrin receptors (for iron acquisition) on immature oligodendrocytes.	Iron	93-97	transferrin	Homo sapiens	66-77
8776576-9	1996	Transferrin protein accumulation and mRNA expression in the brain are both dependent on a viable population of oligodendrocytes and may have an autocrine function to assist oligodendrocytes in iron acquisition.	Iron	193-197	transferrin	Homo sapiens	0-11
8782711-8	1996	The use of intravenous iron combined with erythropoietin seems to be justified to avoid ineffective erythropoieses and to achieve a dose reduction of recombinant erythropoietin.	Iron	23-27	erythropoietin	Homo sapiens	162-176
8704995-0	1996	Utilization of transferrin and salmon serum as sources of iron by typical and atypical strains of Aeromonas salmonicida.	Iron	58-62	transferrin	Homo sapiens	15-26
8806910-6	1996	Hyperoxia increased the amount of the nonsedimentable protein, whereas NO increased the iron saturation of transferrin.	Iron	88-92	transferrin	Rattus norvegicus	107-118
8704995-2	1996	(i) In a plate bioassay, the suppression of growth imposed on typical and atypical A. salmonicida by addition of the high-affinity iron chelator ethylenediamine-di(o- hydroxyphenylacetic acid) (EDDA) to the growth medium was reversed by the addition of 30% or 90% iron-saturated bovine or human transferrin (Tf) or lactoferrin (Lf) to the growth medium.	Iron	131-135	transferrin	Homo sapiens	295-306
8704995-2	1996	(i) In a plate bioassay, the suppression of growth imposed on typical and atypical A. salmonicida by addition of the high-affinity iron chelator ethylenediamine-di(o- hydroxyphenylacetic acid) (EDDA) to the growth medium was reversed by the addition of 30% or 90% iron-saturated bovine or human transferrin (Tf) or lactoferrin (Lf) to the growth medium.	Iron	131-135	transferrin	Homo sapiens	308-310
8671972-0	1996	Regular low-dose intravenous iron therapy improves response to erythropoietin in haemodialysis patients.	Iron	29-33	erythropoietin	Homo sapiens	63-77
8671972-7	1996	In the low ferritin group (n=12), intravenous iron therapy increased serum ferritin levels, and produced a significant rise in haemoglobin, and a significant reduction in Epo dose.	Iron	46-50	erythropoietin	Homo sapiens	171-174
8671972-11	1996	Epo dose pre-iron, 9000 (4000-30 000)-i.u./week, P&lt;0.05).	Iron	13-17	erythropoietin	Homo sapiens	0-3
8671972-12	1996	Similar results were obtained in the normal ferritin group (n=34) following intravenous iron therapy, with significant increases in serum ferritin levels and haemoglobin concentrations, and a significant reduction in Epo dose.	Iron	88-92	erythropoietin	Homo sapiens	217-220
8671972-17	1996	CONCLUSION: Regular intravenous iron supplementation in haemodialysis patients improves the response to Epo therapy.	Iron	32-36	erythropoietin	Homo sapiens	104-107
8767477-1	1996	Hepatocytes can accumulate iron from transferrin via receptor- or non-receptor-mediated endocytosis or from non-transferrin iron complexes.	Iron	27-31	transferrin	Homo sapiens	37-48
8662718-1	1996	Lactoferrin is a member of the transferrin family of iron-binding proteins.	Iron	53-57	transferrin	Homo sapiens	31-42
8662718-7	1996	Like transferrin, lactoferrin consists of two repeated iron-binding lobes that bind one iron atom each.	Iron	55-59	transferrin	Homo sapiens	5-16
8662718-7	1996	Like transferrin, lactoferrin consists of two repeated iron-binding lobes that bind one iron atom each.	Iron	88-92	transferrin	Homo sapiens	5-16
8804698-13	1996	These findings, taken together with previously published data on the distribution of ferritin and transferrin, suggests that iron-enriched cells serve as stores of iron for the brain.	Iron	125-129	transferrin	Rattus norvegicus	98-109
8767477-3	1996	Both pathways have some properties in common and mutually influence each other: Whereas on the one hand the non-permeant chelator DTPA as well as a polymer-conjugated desferrioxamine inhibit uptake of iron from transferrin, transferrin (in both forms, diferric or apo) itself inhibits uptake from the Fe(3+)-DTPA complex.	Iron	201-205	transferrin	Homo sapiens	211-222
8767477-3	1996	Both pathways have some properties in common and mutually influence each other: Whereas on the one hand the non-permeant chelator DTPA as well as a polymer-conjugated desferrioxamine inhibit uptake of iron from transferrin, transferrin (in both forms, diferric or apo) itself inhibits uptake from the Fe(3+)-DTPA complex.	Iron	201-205	transferrin	Homo sapiens	224-235
8675172-1	1996	The hepatic uptake of transferrin-bound iron by a nontransferrin receptor (NTR)-mediated process was investigated using the human hepatoma cell line HuH7.	Iron	40-44	transferrin	Homo sapiens	22-33
8727236-4	1996	The control population included 53 hospitalized patients with expected abnormalities in serum transferrin concentrations caused by conditions such as negative iron balance, pregnancy, or nonalcoholic liver disease.	Iron	159-163	transferrin	Homo sapiens	94-105
8675172-7	1996	This process, like the TR-mediated one, involved the internalization and recycling of transferrin, leading to accumulation of iron with time.	Iron	126-130	transferrin	Homo sapiens	86-97
8675172-8	1996	Iron uptake mediated by NTR process was saturable and displaced by 100-fold excess unlabeled transferrin and reduced by weak bases and metabolic inhibitors.	Iron	0-4	transferrin	Homo sapiens	93-104
8675172-9	1996	Therefore, the NTR-mediated process entailed transferrin adsorption to membrane-bound proteins, internalization, and release of iron from transferrin by a pH-dependent step followed by the intracellular transport of iron into ferritin and heme by a saturable carrier-mediated mechanism.	Iron	128-132	transferrin	Homo sapiens	138-149
8675172-9	1996	Therefore, the NTR-mediated process entailed transferrin adsorption to membrane-bound proteins, internalization, and release of iron from transferrin by a pH-dependent step followed by the intracellular transport of iron into ferritin and heme by a saturable carrier-mediated mechanism.	Iron	216-220	transferrin	Homo sapiens	45-56
8675172-9	1996	Therefore, the NTR-mediated process entailed transferrin adsorption to membrane-bound proteins, internalization, and release of iron from transferrin by a pH-dependent step followed by the intracellular transport of iron into ferritin and heme by a saturable carrier-mediated mechanism.	Iron	216-220	transferrin	Homo sapiens	138-149
8643505-8	1996	The interaction between mammalian IRPs and the aconitase IRE is regulated by iron, nitric oxide, and oxidative stress (H2O2), indicating that these three signals can control the expression of mitochondrial aconitase mRNA.	Iron	77-81	aconitase 2	Homo sapiens	192-215
8813353-1	1996	Heme oxygenase-2 (HO-2) is the predominant heme oxygenase isozyme in neurons in the brain, the enzyme cleaves the heme molecule at the alpha-meso carbon bridge to form CO, Fe and biliverdin.	Iron	172-174	heme oxygenase 2	Rattus norvegicus	0-16
8813353-1	1996	Heme oxygenase-2 (HO-2) is the predominant heme oxygenase isozyme in neurons in the brain, the enzyme cleaves the heme molecule at the alpha-meso carbon bridge to form CO, Fe and biliverdin.	Iron	172-174	heme oxygenase 2	Rattus norvegicus	18-22
8782865-1	1996	Transferrin (Tf) is a major transport protein for both iron (Fe) and aluminum (Al), as well as manganese (Mn) and it can mediate cellular uptake of these elements via cell surface Tf receptors.	Iron	55-59	transferrin	Rattus norvegicus	0-11
8782865-1	1996	Transferrin (Tf) is a major transport protein for both iron (Fe) and aluminum (Al), as well as manganese (Mn) and it can mediate cellular uptake of these elements via cell surface Tf receptors.	Iron	61-63	transferrin	Rattus norvegicus	0-11
8928846-5	1996	With amelioration of anemia and iron overload in group I, insulin sensitivity increased by 53% to within normal values.	Iron	32-36	insulin	Homo sapiens	58-65
8627518-3	1996	By use of monoclonal antibodies that bind to the transferrin receptor present on the luminal surface of brain capillary endothelial cells, we have taken advantage of the transport system responsible for the delivery of iron to the brain to deliver recombinant human soluble CD4 (rsCD4), a potential anti-HIV therapeutic, across the blood-brain barrier.	Iron	219-223	transferrin	Homo sapiens	49-60
8928846-8	1996	Thus correction of anemia by EPO reversed insulin resistance and hyperinsulinemia in HD patients with or without iron overload.	Iron	113-117	erythropoietin	Homo sapiens	29-32
8653897-2	1996	Three degrees of ID are recognized: Iron depletion (ID grade I) is defined by decreased total body iron and normal iron support to erythropoiesis, as diagnosed by decreased storage iron, decreased ferritin, normal sideroblast count, normal zinc protoporphyrin (ZPP), and transferrin saturation &gt;15%.	Iron	36-40	transferrin	Homo sapiens	271-282
8662191-4	1996	The nucleotide sequence of MSS10 is identical to three other genes from S. cerevisiae identified as: FUP1, a gene that enhances iron-limited growth; PHD2, a gene identified for its ability to induce pseudohyphal growth in diploid cells grown on nitrogen-limited media; and MSN1, a gene encoding a transcriptional activator involved in invertase regulation.	Iron	128-132	Msn1p	Saccharomyces cerevisiae S288C	101-105
8613388-2	1996	However, iron is not easily available to microorganisms infecting mammalian hosts, because it is largely sequestered by iron-binding proteins, such as transferrin or lactoferrin, or complexed to heme.	Iron	9-13	transferrin	Homo sapiens	151-162
8613388-2	1996	However, iron is not easily available to microorganisms infecting mammalian hosts, because it is largely sequestered by iron-binding proteins, such as transferrin or lactoferrin, or complexed to heme.	Iron	120-124	transferrin	Homo sapiens	151-162
8773911-4	1996	Diagnosis of iron overload was assessed by transferrin saturation, serum ferritin and iron removed by phlebotomy to reach depletion.	Iron	13-17	transferrin	Homo sapiens	43-54
9054307-2	1996	The ethanol-inducible cytochrome P450 2E1 plays a key role in its generation, favoured itself by an increase in the "redox-active" fraction of intracellular non-heme iron.	Iron	166-170	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	22-41
8627518-3	1996	By use of monoclonal antibodies that bind to the transferrin receptor present on the luminal surface of brain capillary endothelial cells, we have taken advantage of the transport system responsible for the delivery of iron to the brain to deliver recombinant human soluble CD4 (rsCD4), a potential anti-HIV therapeutic, across the blood-brain barrier.	Iron	219-223	CD4 molecule	Homo sapiens	274-277
8671901-3	1996	In two patents complaints of hypotension and malaise during FeGl infusion coincided with high levels of serum iron and a calculated transferrin iron saturation above 100%.	Iron	144-148	transferrin	Homo sapiens	132-143
8871871-1	1996	An individual"s iron status may affect the response rate achieved with the use of interferon (IFN) as therapy for chronic viral hepatitis.	Iron	16-20	interferon alpha 1	Homo sapiens	94-97
8671901-11	1996	Transferrin saturation was calculated from transferrin and serum iron.	Iron	65-69	transferrin	Homo sapiens	0-11
8727598-1	1996	Pathogenic members of the Neisseriaceae and Pasteurellaceae express outer-membrane receptor proteins involved in the direct assimilation of iron from the host glycoproteins transferrin and lactoferrin.	Iron	140-144	transferrin	Homo sapiens	173-184
8619207-7	1996	If iron availability was analyzed, a strong correlation between ferritin blood levels and transferrin iron saturation with hemoglobin response was observed in regression analysis (p &lt; 0.001).	Iron	3-7	transferrin	Homo sapiens	90-101
8619207-7	1996	If iron availability was analyzed, a strong correlation between ferritin blood levels and transferrin iron saturation with hemoglobin response was observed in regression analysis (p &lt; 0.001).	Iron	102-106	transferrin	Homo sapiens	90-101
8612386-2	1996	A new iron formulation was tested in which iron ions are bound to ovotransferrin, a protein that shares more than an 80% similarity with the sequence of human transferrin and apparently is less likely than the commonly used iron salts to reduce drug absorption.	Iron	6-10	transferrin	Homo sapiens	69-80
8645006-8	1996	These findings suggest that ALAS is a key enzyme in the eight steps of de novo heme synthesis and that iron, including FeTf, plays a central role in Hb synthesis through control of ALAS activity in erythroid differentiating cells.	Iron	103-107	5'-aminolevulinate synthase 1	Homo sapiens	181-185
11666437-6	1996	Its formulation as {[Fe(TPA)(OO(t)Bu)(ROH)](ClO(4))}(+) (R = H or CH(2)Ph) is based on the masses observed, isotope distribution patterns, the observation of expected shifts in the mass values by appropriate substitutions, and tandem mass spectral data.	Iron	21-23	plasminogen activator, tissue type	Homo sapiens	24-27
8706315-2	1996	In this study we have determined whether the transferrin receptor, which mediates iron uptake by cells, could be detected immunocytochemically in human pituitary adenomas in vitro.	Iron	82-86	transferrin	Homo sapiens	45-56
8681418-2	1996	Human serum albumin (HSA) was adsorbed significantly on the surface of a bare GC electrode, which was monitored by cyclic voltammetry in the presence of Fe(CN)6(4)-/Fe(CN)6(3)-ions.	Iron	153-155	albumin	Homo sapiens	6-25
8681418-2	1996	Human serum albumin (HSA) was adsorbed significantly on the surface of a bare GC electrode, which was monitored by cyclic voltammetry in the presence of Fe(CN)6(4)-/Fe(CN)6(3)-ions.	Iron	165-167	albumin	Homo sapiens	6-25
8612386-2	1996	A new iron formulation was tested in which iron ions are bound to ovotransferrin, a protein that shares more than an 80% similarity with the sequence of human transferrin and apparently is less likely than the commonly used iron salts to reduce drug absorption.	Iron	43-47	transferrin	Homo sapiens	69-80
8612386-2	1996	A new iron formulation was tested in which iron ions are bound to ovotransferrin, a protein that shares more than an 80% similarity with the sequence of human transferrin and apparently is less likely than the commonly used iron salts to reduce drug absorption.	Iron	43-47	transferrin	Homo sapiens	69-80
8723573-2	1996	Since iron is an essential element for erythropoiesis and hemoglobin (Hb) synthesis, its importance is heightened in patients treated with epoetin alfa.	Iron	6-10	erythropoietin	Homo sapiens	139-146
8730630-7	1996	These results show that the differentiating trophoblast cells respond to pertubations in the (transferrin-mediated) iron supply by adjustments in the rate of TfR synthesis.	Iron	116-120	transferrin	Homo sapiens	94-105
8636031-0	1996	Iron-regulated transcription of the pvdA gene in Pseudomonas aeruginosa: effect of Fur and PvdS on promoter activity.	Iron	0-4	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	36-40
8636031-2	1996	Expression studies with a promoter probe vector made it possible to identify three tightly iron-regulated promoter regions in the 5.9-kb DNA fragment upstream of pvdA.	Iron	91-95	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	162-166
8636031-4	1996	RNA analysis showed that expression of PvdA is iron regulated at the transcriptional level.	Iron	47-51	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	39-43
8636031-15	1996	Our results support the hypothesis that the P. aeruginosa Fur repressor indirectly controls pvdA transcription through the intermediary sigma factor PvdS; in the presence of sufficient iron, Fur blocks the pvdS promoter, thus preventing PvdS expression and consequently transcription of pvdA and other pyoverdin biosynthesis genes.	Iron	185-189	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	92-96
8636031-15	1996	Our results support the hypothesis that the P. aeruginosa Fur repressor indirectly controls pvdA transcription through the intermediary sigma factor PvdS; in the presence of sufficient iron, Fur blocks the pvdS promoter, thus preventing PvdS expression and consequently transcription of pvdA and other pyoverdin biosynthesis genes.	Iron	185-189	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	287-291
8666910-7	1996	Purified desferri-exochelins rapidly removed iron from human transferrin, whether it was 95 or 40% iron saturated, its approximate percent saturation in human serum, and from human lactoferrin.	Iron	45-49	transferrin	Homo sapiens	61-72
8861201-7	1996	Cell-surface reductases, FRE1 and FRE2, provide ferrous iron for both systems.	Iron	56-60	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	25-29
8618185-6	1996	RESULTS: Adequate iron stores were present in all infants, and transferrin concentrations correlated with measured total iron-binding capacity (r = 0.95, p = 0.0001).	Iron	121-125	transferrin	Homo sapiens	63-74
11536750-1	1996	The reaction of iron sulfide (FeS) with H2S in water, in presence of CO2 under anaerobic conditions was found to yield H2 and a variety of organic sulfur compounds, mainly thiols and small amounts of CS2 and dimethyldisulfide.	Iron	30-33	chorionic somatomammotropin hormone 2	Homo sapiens	200-203
11536750-5	1996	Whether thiols or CS2 were formed as the main products depended also on the FeS/HCl-ratio: All conditions which create a H2 deficiency were found to initiate a proportional increase in the amount of CS2.	Iron	76-79	chorionic somatomammotropin hormone 2	Homo sapiens	199-202
8723573-3	1996	Stimulation of erythropoiesis following the administration of epoetin alfa is associated with several changes in iron metabolism; indeed, plasma ferritin levels fall as a result of increased utilization of iron by the expanding erythroid marrow.	Iron	113-117	erythropoietin	Homo sapiens	62-69
8600987-7	1996	Addition of 10 microM S-nitroso-N-acetyl-D,L-penicillamine (SNAP), which produces nitric oxide (NO) in solution, caused a significant increase in iron transport from ferric citrate, but not from Fe-lactoferrin or Fe-transferrin.	Iron	146-150	transferrin	Homo sapiens	216-227
8935653-1	1996	We have examined the effects of heme or vacuole deficiency on the kinetics of induction of cell surface ferrireductase activity and expression of the FRE1 gene encoding a component of ferrireductase, in response to iron or copper deprivation in S. cerevisiae.	Iron	215-219	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	150-154
8723573-3	1996	Stimulation of erythropoiesis following the administration of epoetin alfa is associated with several changes in iron metabolism; indeed, plasma ferritin levels fall as a result of increased utilization of iron by the expanding erythroid marrow.	Iron	206-210	erythropoietin	Homo sapiens	62-69
8723573-5	1996	Thus, iron supplementation is essential to maximize the effect of epoetin alfa-induced erythropoiesis.	Iron	6-10	erythropoietin	Homo sapiens	66-73
8723574-4	1996	Iron availability was a critical factor in determining the response to epoetin alfa.	Iron	0-4	erythropoietin	Homo sapiens	71-78
8723574-6	1996	Parenteral iron supplementation, therefore, ensures that sufficient iron is available to meet the demands of epoetin alfa-accelerated erythropoiesis in patients enrolled in an AB donation program.	Iron	11-15	erythropoietin	Homo sapiens	109-116
8723581-4	1996	Epoetin alfa (100 or 200 IU/kg s.c. on days -30, -23, -16, and -9 prior to surgery, in conjunction with oral iron supplementation) dose-dependently ameliorated the reduction in Hb levels associated with AB donation.	Iron	109-113	erythropoietin	Homo sapiens	0-7
8723584-10	1996	A finding consistent to all studies is that adequate iron supplementation (most probably in parenteral form) is necessary to optimize the erythropoietic response to epoetin alfa in the surgical setting.	Iron	53-57	erythropoietin	Homo sapiens	165-172
11666383-0	1996	Possible Role of the Iron Coordination Sphere in Hemoprotein Electron Transfer Self-Exchange: (1)H NMR Study of the Cytochrome c-PMe(3) Complex.	Iron	21-25	cytochrome c, somatic	Homo sapiens	116-128
8705293-4	1996	We have recently demonstrated that GPI-anchored MTf provides a novel route for cellular iron uptake which is independent of Tf and its receptor.	Iron	88-92	transferrin	Homo sapiens	49-51
8592524-11	1996	CONCLUSIONS: In patients with inflammatory bowel disease and anemia refractory to treatment with iron and vitamins, treatment with oral iron and recombinant erythropoietin can raise hemoglobin levels.	Iron	97-101	erythropoietin	Homo sapiens	157-171
8613658-16	1996	Plasma transferrin receptor level is a reliable index for assessing iron status in populations with rheumatoid arthritis.	Iron	68-72	transferrin	Homo sapiens	7-18
8670069-5	1996	o-Phenanthroline and mannitol blocked GADD153 induction by H2O2, indicating that iron-generated hydroxyl radical mediates this induction.	Iron	81-85	DNA damage inducible transcript 3	Homo sapiens	38-45
9138530-9	1996	When histiocytic iron was markedly present in aspirate material, at least moderate amounts of stainable iron were found in 22 of 25 B-5 fixed and 21 of 25 zinc-formalin fixed decalcified bone marrow.	Iron	17-21	glycoprotein hormone subunit beta 5	Homo sapiens	132-135
9138530-9	1996	When histiocytic iron was markedly present in aspirate material, at least moderate amounts of stainable iron were found in 22 of 25 B-5 fixed and 21 of 25 zinc-formalin fixed decalcified bone marrow.	Iron	104-108	glycoprotein hormone subunit beta 5	Homo sapiens	132-135
8665914-0	1996	A mechanism for iron uptake by transferrin.	Iron	16-20	transferrin	Homo sapiens	31-42
8665914-1	1996	Iron uptake by transferrin from iron nitrilotriacetate (FeNAc3) in the presence of bicarbonate has been investigated in the pH range 6.5-8.	Iron	0-4	transferrin	Homo sapiens	15-26
8665914-6	1996	Finally, the holoprotein or the monoferric transferrin in its final equilibrated state is produced by a third modification in the conformation that occurs after approximately 3000 s. Iron uptake by the N-site does not occur when the apotransferrin interacts with bicarbonate.	Iron	183-187	transferrin	Homo sapiens	43-54
8665914-7	1996	Nevertheless, it occurs with the monoferric transferrin, in which iron is bound to the C-site, in its final state of equilibrium by a mechanism similar to that of iron uptake by the C-site of apotransferrin.	Iron	66-70	transferrin	Homo sapiens	44-55
8665914-7	1996	Nevertheless, it occurs with the monoferric transferrin, in which iron is bound to the C-site, in its final state of equilibrium by a mechanism similar to that of iron uptake by the C-site of apotransferrin.	Iron	163-167	transferrin	Homo sapiens	44-55
8665109-7	1996	Hb, serum iron, serum ferritin, and transferrin saturation increased with iron treatment in both males (P &lt; 0.01) and females (P &lt; 0.05).	Iron	74-78	transferrin	Homo sapiens	36-47
8653995-6	1996	CYP2D6 is apparently involved in the formation of (S)-thioridazine 2-SO(FE), (R)-thioridazine 2-SO(SE), and also probably (S)-thioridazine 5-SO(FE) and (R)-thioridazine 5-SO(SE).	Iron	72-74	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
8653995-6	1996	CYP2D6 is apparently involved in the formation of (S)-thioridazine 2-SO(FE), (R)-thioridazine 2-SO(SE), and also probably (S)-thioridazine 5-SO(FE) and (R)-thioridazine 5-SO(SE).	Iron	144-146	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
8608889-5	1996	Transferrin receptor mRNA was detected in crypt epithelial cells of the small and large intestine in iron-deficient and normal rats.	Iron	101-105	transferrin	Rattus norvegicus	0-11
8608889-6	1996	In contrast, in iron-loaded rats, transferrin receptor mRNA was also detected in the superficial epithelial cells of the small intestine and colon, which contained increased stores of iron.	Iron	16-20	transferrin	Rattus norvegicus	34-45
8608889-6	1996	In contrast, in iron-loaded rats, transferrin receptor mRNA was also detected in the superficial epithelial cells of the small intestine and colon, which contained increased stores of iron.	Iron	184-188	transferrin	Rattus norvegicus	34-45
8608889-8	1996	CONCLUSIONS: In the iron-deficient and normal rat intestine, transferrin receptor mRNA was expressed only by proliferating crypt epithelial cells.	Iron	20-24	transferrin	Rattus norvegicus	61-72
8608889-9	1996	In iron-loaded rats, however, surface enterocytes of the intestine expressed both transferrin receptor mRNA and increased ferritin mRNA levels.	Iron	3-7	transferrin	Rattus norvegicus	82-93
8631722-1	1996	Neisseria gonorrhoeae is capable of iron utilization from human transferrin in a receptor-mediated event.	Iron	36-40	transferrin	Homo sapiens	64-75
8617762-8	1996	These findings suggest that IRP-1 and IRP-2 may each regulate unique mRNA targets in vivo, possibly extending their function beyond the regulation of intracellular iron homeostasis.	Iron	164-168	iron responsive element binding protein 2	Homo sapiens	38-43
8723996-2	1996	METHODS: Diene conjugates, thiobarbituric acid reactive substances, iron-stimulated thiobarbituric acid reactive substances and anti-oxidative capacity of serum were detected in 32 untreated essential hypertension patients with normal glucose tolerance, divided into hyperinsulinaemic (n = 12, fasting plasma insulin level &gt; 13.5 mU/l, means 2 SD of controls) and normo-insulinaemic (n = 20) subgroups, compared with 26 age- and body mass index-matched controls.	Iron	68-72	insulin	Homo sapiens	272-279
8671820-13	1996	iron supplementation in the responders (10% increase of haemoglobin or 20% decrease of the recombinant human erythropoietin dose) compared with the non-responders.	Iron	0-4	erythropoietin	Homo sapiens	109-123
8965674-2	1996	Some of these proteins e.g. transferrin-binding proteins 1 and 2 (Tbp1 and Tbp2), are required for the acquisition of iron from transferrin and are examples of important iron-regulated meningococcal surface antigens which are not expressed after growth in common laboratory media.	Iron	118-122	thioredoxin interacting protein	Mus musculus	75-79
8965674-2	1996	Some of these proteins e.g. transferrin-binding proteins 1 and 2 (Tbp1 and Tbp2), are required for the acquisition of iron from transferrin and are examples of important iron-regulated meningococcal surface antigens which are not expressed after growth in common laboratory media.	Iron	170-174	thioredoxin interacting protein	Mus musculus	75-79
8710158-1	1996	BACKGROUND: Ferritin and the percentage of transferrin saturation (TS) are established parameters with which to evaluate endogenous iron availability during treatment of renal anaemia with recombinant human erythropoietin (rHuEpo).	Iron	132-136	erythropoietin	Homo sapiens	207-221
8728119-0	1996	Human cytochrome P450"s are pro-oxidants in iron/ascorbate-initiated microsomal lipid peroxidation.	Iron	44-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-21
8728119-1	1996	We have examined the effect of human cytochrome P450"s (1A1,1A2,3A4,2A6,2B6,2D6,2E1) on ascorbate/iron-induced lipid peroxidation.	Iron	98-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-52
8728119-4	1996	It is therefore concluded that cytochrome P450"s play a significant role in ascorbate/iron peroxidation.	Iron	86-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-46
8848776-1	1996	The use of erythropoietin in dialysed patients leads to the gradual depletion of the body"s iron reserves.	Iron	92-96	erythropoietin	Homo sapiens	11-25
8848776-2	1996	It is important to assay iron blood levels in both patients receiving Epo therapy and those undergoing dialysis without this treatment.	Iron	25-29	erythropoietin	Homo sapiens	70-73
8767577-1	1996	In twenty eight patients with iron deficiency the efficacy of iron-acetil-transferrin treatment (2-3 mg/kg/die) has been evaluated from the changes of the following variables: RBC and reticulocyte count, Hb concentration, MCV, MCH, serum ferritin, serum iron, TIBC, and ZnPP.	Iron	30-34	transferrin	Homo sapiens	74-85
8611022-4	1996	Iron uptake from Fe(III)-DTPA is completely inhibited by trypsinization of the cell surface, by strong impermeant ferric chelators (DTPA, apo-transferrin, polymer-conjugated desferrioxamine), both hexacyanoferrates, copper and zinc, and partly by dipyridyl, manganese, cobalt, N-ethylmaleimide, and citrate.	Iron	0-4	transferrin	Rattus norvegicus	142-153
8619442-7	1996	Stable IL-4 levels in children given desferrioxamine B may represent an inhibition of the T helper lymphocyte-2 (TH-2) response resulting from a strengthened TH-1 response associated with iron chelation therapy.	Iron	188-192	interleukin 4	Homo sapiens	7-11
8573200-8	1996	Chlorpromazine stimulated iron uptake by cortical synaptosomes more efficiently than Ca2+, at physiological levels, from both [55Fe]transferrin (50%) and [55Fe]citrate (68%).	Iron	26-30	transferrin	Rattus norvegicus	132-143
8623803-10	1996	With iron-negative N. gonorrhoeae addition of either saturated transferrin or unsaturated transferrin significantly increased N. gonorrhoeae adherence although unsaturated transferrin did not permit growth of iron-negative N. gonorrhoeae in tissue culture media alone.	Iron	5-9	transferrin	Homo sapiens	63-74
8561058-8	1996	In pubertal boys with relatively ample iron status, serum transferrin may be an indicator of increased availability of iron for erythropoiesis.	Iron	39-43	transferrin	Homo sapiens	58-69
8561058-8	1996	In pubertal boys with relatively ample iron status, serum transferrin may be an indicator of increased availability of iron for erythropoiesis.	Iron	119-123	transferrin	Homo sapiens	58-69
8623803-10	1996	With iron-negative N. gonorrhoeae addition of either saturated transferrin or unsaturated transferrin significantly increased N. gonorrhoeae adherence although unsaturated transferrin did not permit growth of iron-negative N. gonorrhoeae in tissue culture media alone.	Iron	5-9	transferrin	Homo sapiens	90-101
8659499-12	1996	In conclusion, IV Fe supplementation in two thirds of anemic CRF patients not receiving dialysis resulted in a significant improvement of the anemia, thus avoiding the necessity of erythropoietin or blood administration.	Iron	18-20	erythropoietin	Homo sapiens	181-195
8623803-10	1996	With iron-negative N. gonorrhoeae addition of either saturated transferrin or unsaturated transferrin significantly increased N. gonorrhoeae adherence although unsaturated transferrin did not permit growth of iron-negative N. gonorrhoeae in tissue culture media alone.	Iron	5-9	transferrin	Homo sapiens	90-101
8623803-0	1996	Transferrin increases adherence of iron-deprived Neisseria gonorrhoeae to human endometrial cells.	Iron	35-39	transferrin	Homo sapiens	0-11
8623803-12	1996	An iron-negative N. gonorrhoeae mutant lacking the transferrin receptor exhibited no adherence regardless of addition of saturated transferrin or unsaturated transferrin.	Iron	3-7	transferrin	Homo sapiens	51-62
8850303-0	1996	Recognition of poly-N-acetyllactosaminyl saccharide chains on iron-oxidized erythrocytes by human monocytic leukemia cell line THP-1 differentiated into macrophages.	Iron	62-66	GLI family zinc finger 2	Homo sapiens	127-132
8550201-8	1996	These results strongly suggest that pyoverdin competes directly with transferrin for iron and that it is an essential element for in vivo iron gathering and virulence expression in P. aeruginosa.	Iron	85-89	transferrin	Homo sapiens	69-80
8900955-8	1996	Under these conditions, resolution of the various sialoforms from the iron-saturated Tf was possible and the glycoforms were found to migrate differently than their iron-depleted counterparts.	Iron	70-74	transferrin	Homo sapiens	85-87
8904521-9	1996	Parenteral iron therapy caused a significant increase of ferritin and transferrin saturation, while transferrin concentration decreased.	Iron	11-15	transferrin	Homo sapiens	70-81
8846535-15	1996	Pretransplant rHEPO treatment may limit PTE by blunting the increased sensitivity of erythroid precursors to EPO and iron supplementation, which stimulates the development of PTE.	Iron	117-121	erythropoietin	Homo sapiens	16-19
8592145-3	1996	Previous work has demonstrated that certain metals that have been implicated as risk factors for Alzheimer"s disease (Al, Fe, and Zn) also cause substantial aggregation of A beta.	Iron	122-124	amyloid beta precursor protein	Homo sapiens	172-178
8557646-1	1996	Pathogenic bacteria in the Neisseriaceae and Pasteurellaceae possess outer membrane proteins that specifically bind transferrin from the host as the first step in the iron acquisition process.	Iron	167-171	transferrin	Homo sapiens	116-127
8821818-0	1996	Evidence for cytochrome P-450 as a source of catalytic iron in myoglobinuric acute renal failure.	Iron	55-59	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-29
27414512-2	1996	The ultraviolet-B irradiation of 1.4 mg/ml iron saturated transferrin solutions (~32 muM Fe(3+)) induces a Fe(3+) loss accompanied by Fe(2+) formation.	Iron	43-47	latexin	Homo sapiens	85-88
8821818-12	1996	Our data also indicate that inhibitors of cytochrome P-450 provide protection against glycerol-induced acute renal failure and that cytochrome P-450 may be a significant source of this iron in this model of acute renal failure.	Iron	185-189	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	132-148
8722096-5	1996	Affinity isolation of the bacterial transferrin receptor from the two Haemophilus species revealed that both native ovotransferrin and its C-lobe fragment were capable of isolating two iron repressible outer membrane proteins.	Iron	185-189	transferrin	Homo sapiens	36-47
27414512-0	1996	Iron mobilization from ultraviolet-irradiated, iron-saturated, transferrin.	Iron	0-4	transferrin	Homo sapiens	63-74
27414512-1	1996	Transferrin is the major iron transport protein of mammalian plasma.	Iron	25-29	transferrin	Homo sapiens	0-11
27414512-2	1996	The ultraviolet-B irradiation of 1.4 mg/ml iron saturated transferrin solutions (~32 muM Fe(3+)) induces a Fe(3+) loss accompanied by Fe(2+) formation.	Iron	43-47	transferrin	Homo sapiens	58-69
8550563-4	1996	Liver transferrin suppression by hypolipidemic peroxisome proliferators may result in reduced iron availability as well as modulation of transferrin-induced differentiation processes.	Iron	94-98	transferrin	Homo sapiens	6-17
8571401-4	1996	The presence of oxyradical scavengers, viz., thiourea, mannitol, albumin, superoxide dismutase, catalase and dimethyl sulfoxide caused significant inhibition of degradation of DNA by GHQ and iron.	Iron	191-195	catalase	Homo sapiens	96-104
8781654-0	1996	Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson"s disease cases.	Iron	29-33	lactotransferrin	Homo sapiens	50-66
8767691-0	1996	Effect of iron on erythropoietin production in anaemic piglets.	Iron	10-14	erythropoietin	Homo sapiens	18-32
8767691-1	1996	In the present study the response of plasma erythropoietin to iron injection in anaemic piglets was examined.	Iron	62-66	erythropoietin	Homo sapiens	44-58
8767691-6	1996	In 3 of the 4 piglets, iron injection resulted in a 2-6 fold increase in erythropoietin activity.	Iron	23-27	erythropoietin	Homo sapiens	73-87
8767691-8	1996	It is concluded that in our experiment, iron, per se, has stimulated erythropoietin production.	Iron	40-44	erythropoietin	Homo sapiens	69-83
8865893-1	1996	The efficient use of recombinant human erythropoietin (rHuEPO) requires adequate body stores of iron.	Iron	96-100	erythropoietin	Homo sapiens	39-53
8739277-13	1996	The iron requirements in patients on erythropoietin therapy were higher than in those without (2.63 +/- 1.59 vs. 1.88 +/- 1.68 mg/day; p &lt; 0.05).	Iron	4-8	erythropoietin	Homo sapiens	37-51
8739277-14	1996	However, excluding the menstruating women, the iron need in patients on erythropoietin were similar to those in subjects without this treatment (2.16 +/- 1.13 vs. 1.88 +/- 1.68 mg/day).	Iron	47-51	erythropoietin	Homo sapiens	72-86
8739277-16	1996	We have observed that in subjects on maintenance erythropoietin therapy, the iron requirements are stable.	Iron	77-81	erythropoietin	Homo sapiens	49-63
8881365-0	1996	[Incidence of the standardization of serum transferrin assay by CRM 470 on iron saturation ratio of transferrin].	Iron	75-79	transferrin	Homo sapiens	43-54
8881365-0	1996	[Incidence of the standardization of serum transferrin assay by CRM 470 on iron saturation ratio of transferrin].	Iron	75-79	transferrin	Homo sapiens	100-111
8800477-3	1996	Two X-ray structures of soybean lipoxygenase-1 reveal the side chains of three histidines and the COO- of the carboxy terminus as ligands to the catalytically important iron atom.	Iron	169-173	seed linoleate 13S-lipoxygenase-1	Glycine max	32-46
8550595-12	1996	As expected, both superoxide dismutase and catalase inhibited this Fe-catalyzed oxidation reaction.	Iron	67-69	catalase	Homo sapiens	43-51
8781654-1	1996	Changes in the distribution of the iron-binding protein lactotransferrin have recently been described in the central nervous system during a variety of neurodegenerative disorders.	Iron	35-39	lactotransferrin	Homo sapiens	56-72
8856975-2	1996	Expression of the transferrin receptor is increased when cells are iron-depleted, while expression of the iron sequestration protein ferritin is increased in cells that are iron-replete.	Iron	67-71	transferrin	Homo sapiens	18-29
8769740-9	1996	In fact, the iron chelator deferoxamine (5 mM) completely suppressed the SNP-mediated cytotoxicity and partially attenuated the activity of heme oxygenase to a level equal to that mediated by SIN-1 and SNAP.	Iron	13-17	MAPK associated protein 1	Homo sapiens	192-197
8924594-5	1996	The results indicate that the active site of human CYP2E1 is sterically unhindered directly above the iron for a distance of 10 A.	Iron	102-106	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	51-57
8720902-3	1996	When added to serum supplemented RPMI-1640 culture media, BPS and ascorbate efficiently reduced and competed for iron in Fe(III) transferrin to form Fe(II)(BPS)3.	Iron	113-117	transferrin	Homo sapiens	129-140
8969812-2	1996	Enhancement of the therapeutic benefit of recombinant human erythropoietin (rhEp) in very-low-birth-weight infants will require a better understanding of rhEp"s pharmacodynamic effects including its interaction with iron in stimulating erythropoiesis.	Iron	216-220	erythropoietin	Homo sapiens	60-74
8856975-8	1996	Iron regulatory protein 2 (IRP2) binds similar stem-loop structures, but the mode of regulation of IRP2 is different in that IRP2 is rapidly degraded in iron-replete cells.	Iron	153-157	iron responsive element binding protein 2	Homo sapiens	0-25
8856975-8	1996	Iron regulatory protein 2 (IRP2) binds similar stem-loop structures, but the mode of regulation of IRP2 is different in that IRP2 is rapidly degraded in iron-replete cells.	Iron	153-157	iron responsive element binding protein 2	Homo sapiens	27-31
8904296-5	1996	Serum "free" iron is observed in rare situations such as in severe hemochromatosis in which serum transferrin is saturated.	Iron	13-17	transferrin	Homo sapiens	98-109
8856975-8	1996	Iron regulatory protein 2 (IRP2) binds similar stem-loop structures, but the mode of regulation of IRP2 is different in that IRP2 is rapidly degraded in iron-replete cells.	Iron	153-157	iron responsive element binding protein 2	Homo sapiens	99-103
8904302-8	1996	These data show that the induction of the mdr1 phenotype by transfection of mdr1 gene in 3T3 cells increases susceptibility to irradiation and iron stimulated lipid peroxidation.	Iron	143-147	malic enzyme complex, mitochondrial	Mus musculus	42-46
8856975-8	1996	Iron regulatory protein 2 (IRP2) binds similar stem-loop structures, but the mode of regulation of IRP2 is different in that IRP2 is rapidly degraded in iron-replete cells.	Iron	153-157	iron responsive element binding protein 2	Homo sapiens	99-103
8904302-8	1996	These data show that the induction of the mdr1 phenotype by transfection of mdr1 gene in 3T3 cells increases susceptibility to irradiation and iron stimulated lipid peroxidation.	Iron	143-147	malic enzyme complex, mitochondrial	Mus musculus	76-80
8727377-4	1996	In hepatocytes iron is taken up in the form of transferrin and intercellular iron levels are regulated by IRE/IRE-BP interaction.	Iron	15-19	transferrin	Homo sapiens	47-58
8727377-7	1996	This study revealed that the binding activity of IRE-BP to IRE was increased when HepG2 cells were cultured with an iron-chelating agent, deferoxamine (4.5 microM), and it was decreased when cultured with transferrin (100 micrograms/ml) during both proliferation and differentiational change induced by sodium butyrate.	Iron	116-120	transferrin	Homo sapiens	205-216
8770966-7	1996	Deferoxamine, an iron chelator, also decreased basal ET-1 release.	Iron	17-21	endothelin 1	Homo sapiens	53-57
8808120-1	1996	The study presented here was carried out to evaluate the possible relationship between serum iron and iron transferrin saturation with the response to the deferoxamine test in 86 chronic renal failure patients undergoing hemodialysis.	Iron	102-106	transferrin	Homo sapiens	107-118
8808120-4	1996	The increase in serum aluminum levels after deferoxamine administration (DAI) showed a negative relationship with serum iron levels (r = -0.23; P &lt; 0.05) and iron transferrin saturation (r = -0.26; P &lt; 0.05).	Iron	161-165	transferrin	Homo sapiens	166-177
8808120-5	1996	The correlations improved when analysis of this study included only those patients with high serum iron levels or high iron transferrin saturation (r = -0.55).	Iron	119-123	transferrin	Homo sapiens	124-135
8808120-6	1996	Patients with low probability of having aluminum overload (serum iron levels &lt; 40 micrograms/L and DAI &lt; 150 micrograms/L) had significantly higher values of serum iron, iron transferrin saturation, and serum ferritin levels compared with those patients with a high probability of having aluminum overload (serum aluminum levels &gt; 40 micrograms/L and DAI &gt; 150 micrograms/L).	Iron	65-69	transferrin	Homo sapiens	181-192
8821945-1	1996	Transferrin-binding protein 2 (Tbp2) from Neisseria is an outer membrane-associated extracellular lipoprotein that is involved in iron capture within the infected host.	Iron	130-134	transferrin	Homo sapiens	0-11
8761339-6	1996	We propose a sulfhydryl oxidative mechanism for type I mineralocorticoid receptor inactivation in which iron contaminants might accelerate this process by oxidative catalysis.	Iron	104-108	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	55-81
8926768-1	1996	Under iron-restricted conditions staphylococcal strains could utilize in vitro human body iron sources in form of haemoglobin, haemin, transferrin and lactoferrin.	Iron	6-10	transferrin	Homo sapiens	135-146
8592731-3	1996	Although the role of transferrin in mammalian iron homeostasis has been well characterized, the study of genetic disorders of iron metabolism has revealed other, transferrin-independent, mechanisms by which cells can acquire iron.	Iron	46-50	transferrin	Homo sapiens	21-32
8852489-17	1996	In conclusion, adequate Fe supplementation may allow the target Hct of about 33% to be reached without, or with only very low doses of EPO.	Iron	24-26	erythropoietin	Homo sapiens	135-138
8832602-5	1996	Patients not requiring treatment with rHuEpo had statistically significant higher Epo concentration and lower iron reserves than patients on rHuEpo treatment.	Iron	110-114	erythropoietin	Homo sapiens	41-44
8832602-8	1996	In both groups we found a significant negative correlation between the concentration of Epo and iron stores.	Iron	96-100	erythropoietin	Homo sapiens	88-91
8832602-9	1996	Our results indicate that in patients on HD treatment, plasma Epo level appears to depend either directly or indirectly on iron status.	Iron	123-127	erythropoietin	Homo sapiens	62-65
8592731-3	1996	Although the role of transferrin in mammalian iron homeostasis has been well characterized, the study of genetic disorders of iron metabolism has revealed other, transferrin-independent, mechanisms by which cells can acquire iron.	Iron	126-130	transferrin	Homo sapiens	162-173
8592731-3	1996	Although the role of transferrin in mammalian iron homeostasis has been well characterized, the study of genetic disorders of iron metabolism has revealed other, transferrin-independent, mechanisms by which cells can acquire iron.	Iron	126-130	transferrin	Homo sapiens	162-173
8821649-1	1996	When grown in vivo, or under iron-restriction in vitro, Neisseria meningitidis expresses a number of iron-regulated outer membrane proteins, including two transferrin-binding proteins (Tbp1 and Tbp2).	Iron	101-105	transferrin	Homo sapiens	155-166
8677190-7	1996	Spa therapy for 20 days in Wysowa was accompanied by a significant increase of plasma erythropoietin, iron, ferritin and saturation of transferrin with iron and by an increase of blood haemoglobin and haematocrit value.	Iron	152-156	transferrin	Homo sapiens	135-146
7503059-0	1995	Reduction in recombinant human erythropoietin doses by the use of chronic intravenous iron supplementation.	Iron	86-90	erythropoietin	Homo sapiens	31-45
7493976-0	1995	Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA.	Iron	42-46	transferrin	Homo sapiens	72-83
7503060-0	1995	Reduction in recombinant human erythropoietin doses by the use of chronic intravenous iron supplementation.	Iron	86-90	erythropoietin	Homo sapiens	31-45
7492790-6	1995	Although PIH was far more effective than DFO at preventing Fe uptake from transferrin, it was less effective than DFO at preventing cellular proliferation (DFO ID50 = 22 mumol/L; PIH ID50 = 75 mumol/L).	Iron	59-61	transferrin	Homo sapiens	74-85
8787472-7	1995	During cardiopulmonary bypass it has previously been reported that plasma transferrin can become fully saturated with iron and cause transient iron overload.	Iron	118-122	transferrin	Homo sapiens	74-85
8787472-7	1995	During cardiopulmonary bypass it has previously been reported that plasma transferrin can become fully saturated with iron and cause transient iron overload.	Iron	143-147	transferrin	Homo sapiens	74-85
8586148-5	1995	New concepts concerning its pathogenesis include insulin resistance and beta-cell dysfunction which are apparent well before insulin deficiency and can be reversed if iron depletion is promptly initiated.	Iron	167-171	insulin	Homo sapiens	49-56
8562688-2	1995	HO-2, together with HO-1 (HSP32), catalyzes oxidative cleavage of the heme molecule to biliverdin, carbon monoxide, and iron; HO-2 is the major isozyme of the testis.	Iron	120-124	heme oxygenase 2	Rattus norvegicus	0-4
8562688-2	1995	HO-2, together with HO-1 (HSP32), catalyzes oxidative cleavage of the heme molecule to biliverdin, carbon monoxide, and iron; HO-2 is the major isozyme of the testis.	Iron	120-124	heme oxygenase 2	Rattus norvegicus	126-130
8705373-2	1995	The ethanol-inducible cytochrome P450 2E1 plays a key role in its generation, favoured itself by an increase in the "redox-active " fraction of intracellular non-heme iron.	Iron	167-171	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	22-41
8589365-1	1995	Regulation of iron balance is of particular interest, especially iron absorption, cellular iron metabolism and transferrin-transferrin receptor in hematopoiesis.	Iron	14-18	transferrin	Homo sapiens	111-122
8589365-1	1995	Regulation of iron balance is of particular interest, especially iron absorption, cellular iron metabolism and transferrin-transferrin receptor in hematopoiesis.	Iron	14-18	transferrin	Homo sapiens	123-134
8589365-2	1995	Recent advances in molecular and cell biology have helped to reveal the mysteries of cellular iron metabolism concerning mRNA encoding ferritin and transferrin receptor synthesis.	Iron	94-98	transferrin	Homo sapiens	148-159
8847543-1	1995	All organs including the brain contain iron, and the proteins involved in iron uptake (transferrin and transferrin receptor) and intracellular storage (ferritin).	Iron	74-78	transferrin	Homo sapiens	87-98
8847543-7	1995	Transferrin, the iron-mobilizing protein, is also found predominantly in these cells.	Iron	17-21	transferrin	Homo sapiens	0-11
8847538-7	1995	Several investigators reported the presence of other iron-related proteins in the central nervous system, including transferrin, transferrin receptor, and the ferritin repressor protein.	Iron	53-57	transferrin	Homo sapiens	116-127
8847538-7	1995	Several investigators reported the presence of other iron-related proteins in the central nervous system, including transferrin, transferrin receptor, and the ferritin repressor protein.	Iron	53-57	transferrin	Homo sapiens	129-140
8597165-7	1995	We propose that it is catalyzed by ceruloplasmin, the copper-containing ferroxidase that loads iron into transferrin.	Iron	95-99	transferrin	Homo sapiens	105-116
7578047-3	1995	Mutation of R124, which serves as a principal anchor for the synergistic carbonate anion ordinarily required for iron binding by transferrin, accelerates release.	Iron	113-117	transferrin	Homo sapiens	129-140
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	77-81	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	77-81	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	77-81	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	61-72
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	61-72
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	83-94
7495872-1	1995	On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically.	Iron	101-105	transferrin	Homo sapiens	83-94
7495872-5	1995	What is the relationship between the iron carrier and transferrin receptor?	Iron	37-41	transferrin	Homo sapiens	54-65
7495872-7	1995	And how does iron cross the membrane of the endosomes after it is released from transferrin?	Iron	13-17	transferrin	Homo sapiens	80-91
7488167-3	1995	It is shown here that iron facilitates A beta toxicity to cultured cells.	Iron	22-26	amyloid beta precursor protein	Homo sapiens	39-45
7578047-0	1995	Iron release from recombinant N-lobe and mutants of human transferrin.	Iron	0-4	transferrin	Homo sapiens	58-69
7578047-1	1995	Mutations of kinetically active residues in the recombinant N-lobe of human transferrin may accelerate or retard release of iron from the protein to pyrophosphate, thereby providing means for exploring the individual roles of such residues in the concerted mechanisms of release.	Iron	124-128	transferrin	Homo sapiens	76-87
9815920-1	1995	In preclinical in vitro and in vivo systems, mAbs to human transferrin (Tf) receptors blocked iron uptake from Tf and showed antitumor activity.	Iron	94-98	transferrin	Homo sapiens	59-70
9815920-1	1995	In preclinical in vitro and in vivo systems, mAbs to human transferrin (Tf) receptors blocked iron uptake from Tf and showed antitumor activity.	Iron	94-98	transferrin	Homo sapiens	72-74
9815920-1	1995	In preclinical in vitro and in vivo systems, mAbs to human transferrin (Tf) receptors blocked iron uptake from Tf and showed antitumor activity.	Iron	94-98	transferrin	Homo sapiens	111-113
9815920-13	1995	Anti-Tf receptor antibody was well tolerated and mediated in vivo effects on iron uptake and Tf display.	Iron	77-81	transferrin	Homo sapiens	5-7
7492612-9	1995	In addition, the strong binding of iron to the albumin-BR complex may be clinically important, especially in iron loaded sera of hemochromatosis patients, where the transferrin is fully saturated with this ion and the free iron could catalyze lipid peroxidation unless bound by a metal trapping device such as the albumin-BR complex.	Iron	35-39	transferrin	Homo sapiens	165-176
8579283-1	1995	Biochemical evidence of iron overload (transferrin saturation greater than 60% and/or serum ferritin concentration greater than 1000 micrograms/L) was observed in 16% of patients admitted to an alcohol withdrawal unit.	Iron	24-28	transferrin	Homo sapiens	39-50
8643170-0	1995	Importance of iron supply for erythropoietin therapy.	Iron	14-18	erythropoietin	Homo sapiens	30-44
8643170-18	1995	In the 4th study period, withdrawal of iron administration led to a rapid decrease of serum ferritin and transferrin saturation levels, indicating the absence of severe iron overload.	Iron	39-43	transferrin	Homo sapiens	105-116
7578236-1	1995	The redistribution of the initially-formed myoglobin heme-insertion isomers from the initially formed 50/50 mixture to the equilibrium ratio of 90/10 has long been assumed to occur by one of two mechanisms, both of which require the rupture of the heme iron-protein bond (La Mar, G.N., Toi, H. and Krishnamoorthi, K. (1984) J.	Iron	253-257	myoglobin	Equus caballus	43-52
7489724-0	1995	Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.	Iron	17-21	iron responsive element binding protein 2	Homo sapiens	72-97
7489724-4	1995	The binding activity of IRP2 is regulated by the degradation of the protein when cells are iron-replete.	Iron	91-95	iron responsive element binding protein 2	Homo sapiens	24-28
7489724-5	1995	Here, we demonstrate that a 73 amino acid sequence that corresponds to a unique exon in IRP2 contains a sequence required for rapid degradation in iron-replete cells.	Iron	147-151	iron responsive element binding protein 2	Homo sapiens	88-92
7489724-7	1995	Site-directed mutagenesis has demonstrated that specific cysteines within the IRP2 exon are required for iron-dependent degradation.	Iron	105-109	iron responsive element binding protein 2	Homo sapiens	78-82
7489724-8	1995	The degradation of IRP2 appears to be mediated by the proteasome in iron-replete cells.	Iron	68-72	iron responsive element binding protein 2	Homo sapiens	19-23
8620055-0	1995	Non-transferrin iron uptake by HeLa cells cultured in serum-free media with different iron sources.	Iron	16-20	transferrin	Homo sapiens	4-15
7591059-0	1995	Characterization of an iron-dependent regulatory protein (IdeR) of Mycobacterium tuberculosis as a functional homolog of the diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae.	Iron	23-27	iron-dependent repressor and activator IdeR	Mycobacterium tuberculosis H37Rv	58-62
7591059-0	1995	Characterization of an iron-dependent regulatory protein (IdeR) of Mycobacterium tuberculosis as a functional homolog of the diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae.	Iron	23-27	iron-dependent repressor and activator IdeR	Mycobacterium tuberculosis H37Rv	153-157
7591059-1	1995	The DtxR protein from Corynebacterium diphtheriae is an iron-dependent repressor that regulates transcription from the tox, IRP1, and IRP2 promoters.	Iron	56-60	iron-dependent repressor and activator IdeR	Mycobacterium tuberculosis H37Rv	4-8
7591059-4	1995	In Escherichia coli, transcription from the C. diphtheriae tox, IRP1, and IRP2 promoters was strongly repressed by ideR under high-iron conditions, and ideR restored normal iron-dependent expression of the corynebacterial siderophore in the C. diphtheriae dtxR mutant C7(beta)hm723.	Iron	131-135	iron-dependent repressor and activator IdeR	Mycobacterium tuberculosis H37Rv	115-119
7591059-4	1995	In Escherichia coli, transcription from the C. diphtheriae tox, IRP1, and IRP2 promoters was strongly repressed by ideR under high-iron conditions, and ideR restored normal iron-dependent expression of the corynebacterial siderophore in the C. diphtheriae dtxR mutant C7(beta)hm723.	Iron	173-177	iron-dependent repressor and activator IdeR	Mycobacterium tuberculosis H37Rv	115-119
7591059-4	1995	In Escherichia coli, transcription from the C. diphtheriae tox, IRP1, and IRP2 promoters was strongly repressed by ideR under high-iron conditions, and ideR restored normal iron-dependent expression of the corynebacterial siderophore in the C. diphtheriae dtxR mutant C7(beta)hm723.	Iron	173-177	iron-dependent repressor and activator IdeR	Mycobacterium tuberculosis H37Rv	152-156
8535522-0	1995	Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae.	Iron	54-58	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	26-30
8535522-4	1995	The growth rate of cells in iron-deficient conditions and their ferrireductase activity in the absence of added cadmium were also strongly affected by the dosage of YAP1 and CAD1/YAP2 genes.	Iron	28-32	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	165-169
7492612-9	1995	In addition, the strong binding of iron to the albumin-BR complex may be clinically important, especially in iron loaded sera of hemochromatosis patients, where the transferrin is fully saturated with this ion and the free iron could catalyze lipid peroxidation unless bound by a metal trapping device such as the albumin-BR complex.	Iron	109-113	transferrin	Homo sapiens	165-176
7492612-9	1995	In addition, the strong binding of iron to the albumin-BR complex may be clinically important, especially in iron loaded sera of hemochromatosis patients, where the transferrin is fully saturated with this ion and the free iron could catalyze lipid peroxidation unless bound by a metal trapping device such as the albumin-BR complex.	Iron	109-113	transferrin	Homo sapiens	165-176
7568181-4	1995	Iron acquisition by neurons may occur from iron-transferrin complexes with a direct interaction with specific membrane receptors, but recent results have shown a low density of transferrin receptors in the substantia nigra.	Iron	0-4	transferrin	Homo sapiens	48-59
7577949-4	1995	The labeling was inhibited by arachidonic acid, N-hydroxyurea, and dihydrobenzofuranol inhibitors which have been shown to reduce the non-heme iron center of 5-lipoxygenase.	Iron	143-147	arachidonate 5-lipoxygenase	Homo sapiens	158-172
7592626-0	1995	Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II).	Iron	0-4	transferrin	Homo sapiens	19-30
7592626-1	1995	The release of iron from transferrin (Tf) in the acidic milieu of endosomes and its translocation into the cytosol are integral steps in the process of iron acquisition via receptor-mediated endocytosis (RME).	Iron	15-19	transferrin	Homo sapiens	25-36
7592626-1	1995	The release of iron from transferrin (Tf) in the acidic milieu of endosomes and its translocation into the cytosol are integral steps in the process of iron acquisition via receptor-mediated endocytosis (RME).	Iron	15-19	transferrin	Homo sapiens	38-40
7592626-1	1995	The release of iron from transferrin (Tf) in the acidic milieu of endosomes and its translocation into the cytosol are integral steps in the process of iron acquisition via receptor-mediated endocytosis (RME).	Iron	152-156	transferrin	Homo sapiens	25-36
7592626-1	1995	The release of iron from transferrin (Tf) in the acidic milieu of endosomes and its translocation into the cytosol are integral steps in the process of iron acquisition via receptor-mediated endocytosis (RME).	Iron	152-156	transferrin	Homo sapiens	38-40
7592626-4	1995	Upon exposure to Tf at 37 degrees C, intracellular fluorescence decayed, corresponding to an initial iron uptake of 40 nM/min.	Iron	101-105	transferrin	Homo sapiens	17-19
7592626-5	1995	The Tf-mediated iron uptake was profoundly inhibited by weak bases, the protonophore monensin, energy depletion, or low temperatures (&lt; 25 degrees C), all properties characteristic of RME.	Iron	16-20	transferrin	Homo sapiens	4-6
7592626-7	1995	Conversely, rapidly penetrating, lipophilic iron-(II) chelators such as 2,2"-bipyridyl, evoked swift increases in cell calcein fluorescence, equivalent to sequestration of 0.2-0.5 microM cytosolic iron, depending on the degree of pre-exposure to Tf.	Iron	44-48	transferrin	Homo sapiens	246-248
7592626-9	1995	The finding that the bulk of the in situ cell chelatable pool is comprised of iron(II) was corroborated by pulsing K562 cells with Tf-55Fe, followed by addition of iron(II) and/or iron(III) chelators and extraction of chelator-55Fe complexes into organic solvent.	Iron	78-82	transferrin	Homo sapiens	131-133
7568181-4	1995	Iron acquisition by neurons may occur from iron-transferrin complexes with a direct interaction with specific membrane receptors, but recent results have shown a low density of transferrin receptors in the substantia nigra.	Iron	43-47	transferrin	Homo sapiens	48-59
7485509-0	1995	Evidence for a low Km transporter for non-transferrin-bound iron in isolated rat hepatocytes.	Iron	60-64	transferrin	Rattus norvegicus	42-53
7485509-1	1995	Non-transferrin-bound iron (NTBI) plays an important role in the hepatocellular injury induced by iron overload.	Iron	22-26	transferrin	Rattus norvegicus	4-15
7485509-1	1995	Non-transferrin-bound iron (NTBI) plays an important role in the hepatocellular injury induced by iron overload.	Iron	98-102	transferrin	Rattus norvegicus	4-15
8564405-1	1995	Several iron complexes [FeII(bpy)2(2+), FeII(OPPh3)4(2+), and FeII(PA)2] in combination with hydrogen peroxide (HOOH) catalytically hydroxylate aromatic substrates (ArH).	Iron	8-12	low density lipoprotein receptor adaptor protein 1	Homo sapiens	165-168
7580053-2	1995	Serum albumin, an iron binding compound, was found to stimulate the ascorbate oxidation rate.	Iron	18-22	albumin	Homo sapiens	0-13
7580055-2	1995	The electrophoretic mobilities of these four fractions are identical to those of the iron-transferrin counterparts.	Iron	85-89	transferrin	Homo sapiens	90-101
7580055-3	1995	Simultaneous binding of aluminum and iron to transferrin can also be demonstrated.	Iron	37-41	transferrin	Homo sapiens	45-56
7580055-4	1995	The decreased saturation after IEF indicates that the affinity of transferrin for aluminum is low compared with its affinity for iron.	Iron	129-133	transferrin	Homo sapiens	66-77
8534979-6	1995	On the other hand, iron-saturated transferrin (TF) had cell-growth-stimulating activity, but iron-free TF did not, either in the presence or absence of EGF.	Iron	19-23	transferrin	Rattus norvegicus	34-45
8534979-6	1995	On the other hand, iron-saturated transferrin (TF) had cell-growth-stimulating activity, but iron-free TF did not, either in the presence or absence of EGF.	Iron	19-23	transferrin	Rattus norvegicus	47-49
8590632-0	1995	Iron deprivation results in an increase in p53 expression.	Iron	0-4	tumor protein p53	Homo sapiens	43-46
8590632-1	1995	Deferoxamine (DFO)-induced iron deprivation caused an increase in p53 expression in ML-1 and Raji cells.	Iron	27-31	tumor protein p53	Homo sapiens	66-69
7662974-0	1995	Effects of iron-depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase.	Iron	11-15	cyclin A2	Homo sapiens	129-137
7671248-7	1995	The hydroxyurea-induced increase in transferrin receptor was abrogated by transferrin-iron.	Iron	86-90	transferrin	Homo sapiens	36-47
7671248-7	1995	The hydroxyurea-induced increase in transferrin receptor was abrogated by transferrin-iron.	Iron	86-90	transferrin	Homo sapiens	74-85
7558284-1	1995	Haemophilus influenzae has the ability to obtain iron from human transferrin via two bacterial cell surface transferrin binding proteins, Tbp1 and Tbp2.	Iron	49-53	transferrin	Homo sapiens	65-76
7558284-1	1995	Haemophilus influenzae has the ability to obtain iron from human transferrin via two bacterial cell surface transferrin binding proteins, Tbp1 and Tbp2.	Iron	49-53	transferrin	Homo sapiens	108-119
7558284-7	1995	In addition, all of the strains were capable of growing on human transferrin specifically, indicating that the mechanism of iron assimilation from transferrin is functional and is not siderophore mediated.	Iron	124-128	transferrin	Homo sapiens	65-76
7558284-7	1995	In addition, all of the strains were capable of growing on human transferrin specifically, indicating that the mechanism of iron assimilation from transferrin is functional and is not siderophore mediated.	Iron	124-128	transferrin	Homo sapiens	147-158
7503419-2	1995	Varying the focusing conditions we found (i) Point of sample application (anode, middle of the gel, cathode) strongly affected transferrin iron loss.	Iron	139-143	transferrin	Homo sapiens	127-138
7503419-4	1995	(ii) Without prerun, distinct transferrin iron loss also occurred.	Iron	42-46	transferrin	Homo sapiens	30-41
7503419-7	1995	In conclusion, inappropriate isoelectric focusing conditions strongly affect iron load stability of isotransferrins (obviously via low pH within the gel), resulting in transferrin iron release and cofocusing of isotransferrins with different sialic acid or iron contents.	Iron	77-81	transferrin	Homo sapiens	103-114
7503419-7	1995	In conclusion, inappropriate isoelectric focusing conditions strongly affect iron load stability of isotransferrins (obviously via low pH within the gel), resulting in transferrin iron release and cofocusing of isotransferrins with different sialic acid or iron contents.	Iron	180-184	transferrin	Homo sapiens	103-114
7503419-7	1995	In conclusion, inappropriate isoelectric focusing conditions strongly affect iron load stability of isotransferrins (obviously via low pH within the gel), resulting in transferrin iron release and cofocusing of isotransferrins with different sialic acid or iron contents.	Iron	180-184	transferrin	Homo sapiens	103-114
8707445-11	1995	These data suggest that the action of tepoxalin to inhibit proliferation in PBMC may be at least in part due to its ability to reduce the amount of available iron resulting in decreased activation of NF kappa B and subsequent inhibition of cytokine production.	Iron	158-162	nuclear factor kappa B subunit 1	Homo sapiens	200-210
7665579-0	1995	Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	48-73
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	54-58	iron responsive element binding protein 2	Homo sapiens	9-13
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	iron responsive element binding protein 2	Homo sapiens	9-13
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	iron responsive element binding protein 2	Homo sapiens	69-73
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	iron responsive element binding protein 2	Homo sapiens	9-13
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	iron responsive element binding protein 2	Homo sapiens	69-73
7665579-5	1995	The iron-dependent decrease in IRP2 levels was not due to a decrease in the amount of IRP2 mRNA or to a decrease in the rate of IRP2 synthesis.	Iron	4-8	iron responsive element binding protein 2	Homo sapiens	31-35
7665579-6	1995	Pulse-chase experiments demonstrated that iron resulted in a 3-fold increase in the degradation rate of IRP2.	Iron	42-46	iron responsive element binding protein 2	Homo sapiens	104-108
7665579-9	1995	These data suggest the involvement of the proteasome in iron-mediated IRP2 proteolysis.	Iron	56-60	iron responsive element binding protein 2	Homo sapiens	70-74
9383466-5	1995	DNA is used both to encode a marker gene and as a molecular scaffold, which electrostatically binds polylysine conjugated to transferrin, an iron uptake protein, and polylysine modified with gadolinium chelated to diethylenetriaminepetaacetic acid.	Iron	141-145	transferrin	Homo sapiens	125-136
8554902-0	1995	Iron chelation decreases NF-kappa B and HIV type 1 activation due to oxidative stress.	Iron	0-4	nuclear factor kappa B subunit 1	Homo sapiens	25-35
8554902-10	1995	Other chemically unrelated iron chelators also provided protection against cytotoxicity, NF-kappa B activation, and HIV-1 activation in U1 cells challenged with H2O2.	Iron	27-31	nuclear factor kappa B subunit 1	Homo sapiens	89-99
8652956-3	1995	Infants with high serum ferritin, serum transferrin and erythrocyte protoporphyrin values at one blood sampling also had high values at the following sample (tracking, r=0.45-0.80), suggesting that iron stores at delivery are an important determinant of iron stores during late infancy.	Iron	198-202	transferrin	Homo sapiens	40-51
8521335-0	1995	Human recombinant erythropoietin and phlebotomy in the treatment of iron overload in uremic patients.	Iron	68-72	erythropoietin	Homo sapiens	18-32
8521335-7	1995	Our experience indicates that EPO therapy alone has its limitations in treating severe iron overload.	Iron	87-91	erythropoietin	Homo sapiens	30-33
7673115-9	1995	Although Me2SO, sodium formate, and mannitol had no protective effect, iron chelators, thiourea and urate protected the cells against the SIN-1 plus Cu,Zn-SOD-mediated cytotoxicity.	Iron	71-75	superoxide dismutase 1	Homo sapiens	155-158
7673117-1	1995	Characterization of non-transferrin (non-Tf) iron transport by K562 cells has revealed unique properties relative to iron uptake mechanisms present in other cell types (Inman, R. S., and Wessling-Resnick, M. (1993) J. Biol.	Iron	45-49	transferrin	Homo sapiens	24-35
7556058-6	1995	These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals.	Iron	63-67	transferrin	Homo sapiens	100-111
7556058-6	1995	These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals.	Iron	134-138	transferrin	Homo sapiens	100-111
7556058-1	1995	The established process for iron uptake into mammalian cells involves transferrin and its receptor.	Iron	28-32	transferrin	Homo sapiens	70-81
7556141-0	1995	Uptake of iron from N-terminal half-transferrin by isolated rat hepatocytes.	Iron	10-14	transferrin	Rattus norvegicus	36-47
7544791-0	1995	Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron.	Iron	83-87	iron responsive element binding protein 2	Homo sapiens	62-67
7544791-5	1995	The in vivo iron regulation of IRP-1 and IRP-2 appeared to involve different pathways.	Iron	12-16	iron responsive element binding protein 2	Homo sapiens	41-46
7544791-11	1995	IRP-2 inactivation/degradation occurred upon readdition of iron, but it required translation of another protein.	Iron	59-63	iron responsive element binding protein 2	Homo sapiens	0-5
7557325-4	1995	The binding of transferrin was much increased when organisms were grown in iron-limited conditions.	Iron	75-79	transferrin	Homo sapiens	15-26
7557325-7	1995	These results suggest that the binding of transferrin to P. gingivalis cells may be a preliminary step in iron acquisition, which allows them to survive in the healthy periodontal environment.	Iron	106-110	transferrin	Homo sapiens	42-53
8528518-2	1995	Previous studies have demonstrated that apart from transferrin-bound iron uptake, mammalian cells also possess a transport system capable of efficiently obtaining iron from small molecular weight iron chelates (Sturrock et al., 1990).	Iron	69-73	transferrin	Homo sapiens	51-62
8528518-6	1995	When grown in medium containing transferrin, both regular and low-iron dependent cell lines use transferrin-bound iron.	Iron	66-70	transferrin	Homo sapiens	32-43
8528518-6	1995	When grown in medium containing transferrin, both regular and low-iron dependent cell lines use transferrin-bound iron.	Iron	66-70	transferrin	Homo sapiens	96-107
8528518-6	1995	When grown in medium containing transferrin, both regular and low-iron dependent cell lines use transferrin-bound iron.	Iron	114-118	transferrin	Homo sapiens	32-43
8528518-6	1995	When grown in medium containing transferrin, both regular and low-iron dependent cell lines use transferrin-bound iron.	Iron	114-118	transferrin	Homo sapiens	96-107
8528518-8	1995	On the contrary, growth of low-iron dependent cell lines in transferrin-free, low-iron medium (5 microM ferric citrate) could not be inhibited by monoclonal antibody 42/6.	Iron	31-35	transferrin	Homo sapiens	60-71
8528518-11	1995	We conclude that low-iron dependent tumor cells in transferrin-free, low-iron medium may employ a previously unknown mechanism for uptake of non-transferrin-bound iron that allows them to efficiently use low concentrations of ferric citrate as an iron source.	Iron	21-25	transferrin	Homo sapiens	51-62
8528518-11	1995	We conclude that low-iron dependent tumor cells in transferrin-free, low-iron medium may employ a previously unknown mechanism for uptake of non-transferrin-bound iron that allows them to efficiently use low concentrations of ferric citrate as an iron source.	Iron	21-25	transferrin	Homo sapiens	145-156
8528518-11	1995	We conclude that low-iron dependent tumor cells in transferrin-free, low-iron medium may employ a previously unknown mechanism for uptake of non-transferrin-bound iron that allows them to efficiently use low concentrations of ferric citrate as an iron source.	Iron	73-77	transferrin	Homo sapiens	145-156
8528518-11	1995	We conclude that low-iron dependent tumor cells in transferrin-free, low-iron medium may employ a previously unknown mechanism for uptake of non-transferrin-bound iron that allows them to efficiently use low concentrations of ferric citrate as an iron source.	Iron	73-77	transferrin	Homo sapiens	145-156
8528518-11	1995	We conclude that low-iron dependent tumor cells in transferrin-free, low-iron medium may employ a previously unknown mechanism for uptake of non-transferrin-bound iron that allows them to efficiently use low concentrations of ferric citrate as an iron source.	Iron	73-77	transferrin	Homo sapiens	145-156
7556141-1	1995	Evidence of transferrin-receptor-independent iron uptake.	Iron	45-49	transferrin	Rattus norvegicus	12-23
7556141-2	1995	The aim of the present study was to determine if human N-terminal half-transferrin (N- fragment), prepared by thermolysin cleavage of diferric transferrin, would bind to the rat hepatocyte transferrin receptor and donate iron to the cell.	Iron	221-225	transferrin	Homo sapiens	71-82
7556141-8	1995	This suggests that iron derived from diferric transferrin competes with the iron derived from the N-fragment for a common transport pathway.	Iron	19-23	transferrin	Rattus norvegicus	46-57
7556141-8	1995	This suggests that iron derived from diferric transferrin competes with the iron derived from the N-fragment for a common transport pathway.	Iron	76-80	transferrin	Rattus norvegicus	46-57
7556141-10	1995	The results show that the hepatocyte has an effective transferrin-receptor-independent mechanism for accumulation of iron from transferrin.	Iron	117-121	transferrin	Rattus norvegicus	54-65
7556141-10	1995	The results show that the hepatocyte has an effective transferrin-receptor-independent mechanism for accumulation of iron from transferrin.	Iron	117-121	transferrin	Rattus norvegicus	127-138
8535287-4	1995	The recycling amplitude was related to the occupancy of iron ligated transferrin to plasma membrane surface receptors.	Iron	56-60	transferrin	Homo sapiens	69-80
7676035-0	1995	[A new inducible transferrin-independent iron uptake system involved with aluminum accumulation in the brain of patients with Alzheimer"s disease].	Iron	41-45	transferrin	Homo sapiens	17-28
7639530-2	1995	Several antioxidant compounds and iron chelators have been shown to interfere with both NF-kappa B and HIV-1 activation under oxidative stress.	Iron	34-38	nuclear factor kappa B subunit 1	Homo sapiens	88-98
8554925-6	1995	Addition of extracellular Fe59-transferrin to cultures of ROS 17/2.8 cells resulted in the sequestration of the iron in intracellular ferritin.	Iron	112-116	transferrin	Rattus norvegicus	31-42
7584619-1	1995	Transferrin is a glycoprotein functioning in iron transport in higher eukaryotes, and consists of two highly homologous domains.	Iron	45-49	transferrin	Homo sapiens	0-11
7472906-2	1995	With the potential for increased use of erythropoietin in the preterm infant, iron requirements may become markedly higher.	Iron	78-82	erythropoietin	Homo sapiens	40-54
8529623-0	1995	Separation of tryptophan-derivative enantiomers with iron-free human serum transferrin by capillary zone electrophoresis.	Iron	53-57	transferrin	Homo sapiens	75-86
8529623-3	1995	Tryptophan methyl, ethyl and butyl ester enantiomers-moving towards the cathode at pH 6-were resolved by passing through an iron-free transferrin zone in coated capillaries.	Iron	124-128	transferrin	Homo sapiens	134-145
8529623-4	1995	Since the isoelectric point of the iron-free transferrin is a little higher than 6, the protein zone is either not moving in the experiment or is slowly moving towards the anode.	Iron	35-39	transferrin	Homo sapiens	45-56
7616227-4	1995	Although there were no differences between control groups with regard to concentrations of iron and transferrin, iron was significantly increased (p < 0.05) in Alzheimer"s disease globus pallidus and frontal cortex and Parkinson"s disease globus pallidus, and transferrin was significantly increased in Alzheimer"s disease frontal cortex, compared with elderly controls.	Iron	113-117	transferrin	Homo sapiens	260-271
7616227-5	1995	The transferrin/iron ratio, a measure of iron mobilization capacity, was decreased in globus pallidus and caudate in both disorders.	Iron	41-45	transferrin	Homo sapiens	4-15
7616227-7	1995	The altered relationship between iron and transferrin provides further evidence that a disturbance in iron metabolism may be involved in both disorders.	Iron	33-37	transferrin	Homo sapiens	42-53
7616227-7	1995	The altered relationship between iron and transferrin provides further evidence that a disturbance in iron metabolism may be involved in both disorders.	Iron	102-106	transferrin	Homo sapiens	42-53
9981502-0	1995	Magnetism of Fe, Ni, and Zn in Nd1.85Ce0.15CuO4: Comparison of experiment and theory.	Iron	13-15	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	31-34
7628272-2	1995	The role of transferrin in iron absorption by the duodenal mucosa in rats with iron deficiency and controls was evaluated immunohistochemically.	Iron	27-31	transferrin	Rattus norvegicus	12-23
7626132-0	1995	The 5"-untranslated region of human transferrin mRNA, which contains a putative iron-regulatory element, is bound by purified iron-regulatory protein in a sequence-specific manner.	Iron	80-84	transferrin	Homo sapiens	36-47
7626132-1	1995	Human transferrin mRNA contains a 5"-untranslated region that (1) has homology to an iron responsive element and (2) is implicated in translational iron regulation of human transferrin transgenes in transgenic mice.	Iron	85-89	transferrin	Homo sapiens	6-17
7626132-1	1995	Human transferrin mRNA contains a 5"-untranslated region that (1) has homology to an iron responsive element and (2) is implicated in translational iron regulation of human transferrin transgenes in transgenic mice.	Iron	148-152	transferrin	Homo sapiens	6-17
7626132-1	1995	Human transferrin mRNA contains a 5"-untranslated region that (1) has homology to an iron responsive element and (2) is implicated in translational iron regulation of human transferrin transgenes in transgenic mice.	Iron	148-152	transferrin	Homo sapiens	173-184
7626132-3	1995	Structural differences between the ferritin iron-responsive element and the human transferrin putative iron-responsive element may influence their iron-regulatory protein interactions and direct the differing translational responses.	Iron	44-48	transferrin	Homo sapiens	82-93
7626132-3	1995	Structural differences between the ferritin iron-responsive element and the human transferrin putative iron-responsive element may influence their iron-regulatory protein interactions and direct the differing translational responses.	Iron	103-107	transferrin	Homo sapiens	82-93
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	38-42	transferrin	Homo sapiens	26-37
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	38-42	transferrin	Homo sapiens	251-262
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	38-42	transferrin	Homo sapiens	251-262
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	101-105	transferrin	Homo sapiens	26-37
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	101-105	transferrin	Homo sapiens	26-37
7629083-1	1995	Since reticulocytes have a high demand for iron, which is required for heme biosynthesis, these cells are highly specialized in the endocytosis of the iron carrier transferrin (Tf).	Iron	43-47	transferrin	Homo sapiens	164-175
7629083-1	1995	Since reticulocytes have a high demand for iron, which is required for heme biosynthesis, these cells are highly specialized in the endocytosis of the iron carrier transferrin (Tf).	Iron	43-47	transferrin	Homo sapiens	177-179
7629083-1	1995	Since reticulocytes have a high demand for iron, which is required for heme biosynthesis, these cells are highly specialized in the endocytosis of the iron carrier transferrin (Tf).	Iron	151-155	transferrin	Homo sapiens	164-175
7629083-1	1995	Since reticulocytes have a high demand for iron, which is required for heme biosynthesis, these cells are highly specialized in the endocytosis of the iron carrier transferrin (Tf).	Iron	151-155	transferrin	Homo sapiens	177-179
7675003-12	1995	CONCLUSION: Our data suggest that the long lasting effect of EA is not only due to the high volume removal of RBC itself, but also to the growth inhibition of EPO-independent and -dependent BFU-E which is obviously mediated by the considerable loss of iron by EA.	Iron	252-256	erythropoietin	Homo sapiens	159-162
7611266-0	1995	Reduction in recombinant human erythropoietin doses by the use of chronic intravenous iron supplementation.	Iron	86-90	erythropoietin	Homo sapiens	31-45
7628469-0	1995	Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate.	Iron	15-19	seed linoleate 13S-lipoxygenase-1	Glycine max	50-64
7628469-1	1995	Fe K-edge X-ray absorption spectra of the non-heme iron constituent of lipoxygenase-1 from soybeans were obtained.	Iron	0-2	seed linoleate 13S-lipoxygenase-1	Glycine max	71-85
7628469-1	1995	Fe K-edge X-ray absorption spectra of the non-heme iron constituent of lipoxygenase-1 from soybeans were obtained.	Iron	51-55	seed linoleate 13S-lipoxygenase-1	Glycine max	71-85
7628272-6	1995	In iron-deficient rats, transferrin was weakly stained after iron administration but was strongly stained after saline administration.	Iron	3-7	transferrin	Rattus norvegicus	24-35
7628272-6	1995	In iron-deficient rats, transferrin was weakly stained after iron administration but was strongly stained after saline administration.	Iron	61-65	transferrin	Rattus norvegicus	24-35
7628272-7	1995	In contrast, in controls, transferrin was weakly stained after saline administration but was strongly stained after iron administration.	Iron	116-120	transferrin	Rattus norvegicus	26-37
7628272-9	1995	In iron-deficient rats, accumulation of electron-dense transferrin-negative microgranules was observed in some of the duodenal columnar epithelium.	Iron	3-7	transferrin	Rattus norvegicus	55-66
7616107-1	1995	Exposure to hypochlorous acid (HOCl), the main product of the reaction of neutrophil myeloperoxidase (MPO), H2O2, and Cl-, reportedly decreases apotransferrin"s iron binding capacity.	Iron	161-165	myeloperoxidase	Homo sapiens	85-100
7602028-6	1995	Iron status was explored by measuring erythrocyte mean cell volume (MCV), hemoglobin (Hb), serum iron (Fe), TIBC, percent transferrin saturation (% TS) and ferritin (SF).	Iron	0-4	transferrin	Homo sapiens	122-133
7602028-8	1995	MAIN RESULTS: In the whole series, CRP correlated significantly with all iron status variables except erythrocyte MCV (directly with SF, inversely with the others) and correlated inversely with Alb and pre-Alb.	Iron	73-77	C-reactive protein	Homo sapiens	35-38
7616107-12	1995	HCO3- and H2PO4- may protect apotransferrin from MPO-mediated oxidative damage by preventing selective oxidation of one or both iron binding sites.	Iron	128-132	myeloperoxidase	Homo sapiens	49-52
7616107-13	1995	This process may allow transferrin to retain its iron binding function during MPO exposure in vivo.	Iron	49-53	transferrin	Homo sapiens	23-34
7608520-19	1995	We suggest that transferrin or a transferrin-like substance may have a local role in the transport of iron or other metals or may play a role as growth factor in the three lobes of the pituitary gland.	Iron	102-106	transferrin	Rattus norvegicus	16-27
7608520-19	1995	We suggest that transferrin or a transferrin-like substance may have a local role in the transport of iron or other metals or may play a role as growth factor in the three lobes of the pituitary gland.	Iron	102-106	transferrin	Rattus norvegicus	33-44
7616107-13	1995	This process may allow transferrin to retain its iron binding function during MPO exposure in vivo.	Iron	49-53	myeloperoxidase	Homo sapiens	78-81
7616107-1	1995	Exposure to hypochlorous acid (HOCl), the main product of the reaction of neutrophil myeloperoxidase (MPO), H2O2, and Cl-, reportedly decreases apotransferrin"s iron binding capacity.	Iron	161-165	myeloperoxidase	Homo sapiens	102-105
7616107-2	1995	Optimal transferrin iron binding requires the coexistent binding of anions such as bicarbonate (HCO3-) near the protein"s two iron binding sites.	Iron	20-24	transferrin	Homo sapiens	8-19
7616107-2	1995	Optimal transferrin iron binding requires the coexistent binding of anions such as bicarbonate (HCO3-) near the protein"s two iron binding sites.	Iron	126-130	transferrin	Homo sapiens	8-19
7616107-5	1995	Although the MPO system decreased apotransferrin iron uptake to only 46% of the untreated apotransferrin control, apotransferrin treated in the presence of 1 mM HCO3- or H2PO4- retained 84 and 74%, respectively, of its iron binding capacity.	Iron	49-53	myeloperoxidase	Homo sapiens	13-16
8533287-1	1995	Serum antibody responses to the 70, 77, and 100 kDa iron-regulated outer membrane proteins (IROMPs) of Pasteurella haemolytica A1 were studied in cattle vaccinated with outer membrane protein (OMP) enriched outer membrane fraction, IROMP-enriched outer membrane fraction or live P. haemolytica.	Iron	52-56	OMP	Bos taurus	67-89
7553362-1	1995	The iron-chelating proteins lactoferrin and transferrin have been shown to be bactericidal for a variety of organisms.	Iron	4-8	transferrin	Homo sapiens	44-55
8533287-1	1995	Serum antibody responses to the 70, 77, and 100 kDa iron-regulated outer membrane proteins (IROMPs) of Pasteurella haemolytica A1 were studied in cattle vaccinated with outer membrane protein (OMP) enriched outer membrane fraction, IROMP-enriched outer membrane fraction or live P. haemolytica.	Iron	52-56	OMP	Bos taurus	94-97
7781367-1	1995	Transferrin serves as the primary iron transport protein in serum, but it also is present in the lower respiratory tract where it has antioxidant and antibacterial properties.	Iron	34-38	transferrin	Homo sapiens	0-11
7539275-0	1995	Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages.	Iron	0-4	tumor necrosis factor	Rattus norvegicus	57-84
7539275-4	1995	We have examined the role of iron-catalyzed ROS in asbestos induction of TNF-alpha from rat alveolar macrophages.	Iron	29-33	tumor necrosis factor	Rattus norvegicus	73-82
7539275-5	1995	Treatment of alveolar macrophage cultures with asbestos stimulated dose-dependently TNF-alpha secretion, which was inhibited by the addition of deferoxamine, an iron chelator.	Iron	161-165	tumor necrosis factor	Rattus norvegicus	84-93
7778572-10	1995	Transferrin saturation &gt; or = 50%, suggestive of iron overload, was significantly more frequent in the liver disease group (P = 0.002); and saturation &lt; or = 15%, suggestive of iron-deficient erythropoiesis, was significantly more frequent in the HIV group (P = 0.001).	Iron	52-56	transferrin	Homo sapiens	0-11
7788851-0	1995	Cells transfected with transferrin receptor cDNA lacking the iron regulatory domain become more sensitive to the DNA-damaging action of oxidative stress.	Iron	61-65	transferrin	Homo sapiens	23-34
7788851-3	1995	It exhibited the cDNA sequences recombined into the genome, transcribed the corresponding mRNA and became partially constitutive in iron uptake from transferrin.	Iron	132-136	transferrin	Homo sapiens	149-160
7788851-7	1995	It also points to the possibility that mutations at the regulatory sequences of transferrin receptors, leading to partial disturbance in iron homeostasis, might render the cells more prone to further mutations and malignant transformations by reactive oxygen species.	Iron	137-141	transferrin	Homo sapiens	80-91
7601141-0	1995	Transferrin, a mechanism for iron release.	Iron	29-33	transferrin	Homo sapiens	0-11
7601141-1	1995	Iron release from transferrin has been investigated in mildly acidic and acidic media in the presence of formate, acetate and citrate.	Iron	0-4	transferrin	Homo sapiens	18-29
7539275-6	1995	Asbestos fibers, pretreated with deferoxamine to remove iron from the fibers before addition to alveolar macrophages, also significantly reduced the TNF-alpha response.	Iron	56-60	tumor necrosis factor	Rattus norvegicus	149-158
7539275-10	1995	These results suggest that intracellularly generated ROS can stimulate TNF-alpha in alveolar macrophages and that asbestos-induced TNF-alpha gene expression and secretion are mediated by iron-catalyzed product of ROS.	Iron	187-191	tumor necrosis factor	Rattus norvegicus	131-140
7541940-6	1995	These similarities with established characteristics of erythropoietin regulation indicate that a similar mechanism of oxygen sensing is operating on a variety of vascular growth factors, and they suggest that chelatable iron is closely involved in the mechanism.	Iron	220-224	erythropoietin	Homo sapiens	55-69
7756663-3	1995	More than one-third of children in both the placebo- and iron chelator-treated groups had transferrin saturations exceeding 43%, which is 3 standard deviations above the expected mean for age.	Iron	57-61	transferrin	Homo sapiens	90-101
7607208-0	1995	Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase.	Iron	59-63	arachidonate 5-lipoxygenase	Homo sapiens	75-89
7607208-1	1995	The non-heme iron centre in human 5-lipoxygenase was studied.	Iron	13-17	arachidonate 5-lipoxygenase	Homo sapiens	34-48
7607208-7	1995	We conclude that Ile673 is an iron ligand in 5-lipoxygenase, while our results do not support that Glu376 or Asn554 have this function.	Iron	30-34	arachidonate 5-lipoxygenase	Homo sapiens	45-59
7633578-4	1995	Fe(V) + amino acid--&gt;Fe(III) + NH3 + alpha-keto acid The rate-determining process is the two electron reduction of ferrate(V) to iron(III) with oxidation and subsequent deamination of the amino acid.	Iron	132-136	FEV transcription factor, ETS family member	Homo sapiens	0-5
7671940-7	1995	CONCLUSION: Our data suggest that growth hormone neurosecretory dysfunction is not a universal finding in children with thalassaemia major but might depend on the degree of iron deposit in the pituitary.	Iron	173-177	growth hormone 1	Homo sapiens	34-48
8527044-1	1995	Transferrin receptor (TR) performs the major function of binding and internalizing its specific iron-loaded ligand, transferrin, and its expression is closely linked to the proliferation status of the cell.	Iron	96-100	transferrin	Rattus norvegicus	116-127
7672622-12	1995	A reduction in the expression of the transferrin receptor after incubation with high concentrations of Fe supports this conclusion.	Iron	103-105	transferrin receptor	Canis lupus familiaris	37-57
7760025-3	1995	We now report that the release of iron from either transferrin or ferritin-bound iron, after a decrease in intracellular pH, also leads to the induction of ferritin synthesis.	Iron	34-38	transferrin	Homo sapiens	51-62
7760025-4	1995	The hypoxic induction of ferritin synthesis can be blocked either with iron chelators (deferoxamine or phenanthroline) or by preventing intracellular acidification (which is required for the release of transferrin-bound iron) with weak base treatment (ammonium chloride and amantadine).	Iron	220-224	transferrin	Homo sapiens	202-213
7496135-1	1995	Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity.	Iron	24-28	transferrin	Homo sapiens	101-112
7769095-1	1995	Previous work has shown that the Pseudomonas-derived protease, pseudomonas elastase (PAE), can modify transferrin to form iron complexes capable of catalyzing the formation of hydroxyl radical (.OH) from neutrophil (PMN)-derived superoxide (.O2-) and hydrogen peroxide (H2O2).	Iron	122-126	transferrin	Homo sapiens	102-113
7769095-4	1995	Iron associated with transferrin appeared to be responsible for cell injury.	Iron	0-4	transferrin	Homo sapiens	21-32
7760051-6	1995	This large "inactive" intracellular transferrin receptor pool could either function as a storage site for spare receptors or be activated by the cell to increase its capacity for iron transport.	Iron	179-183	transferrin	Homo sapiens	36-47
7766711-0	1995	Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells.	Iron	28-32	transferrin	Homo sapiens	45-56
7566365-2	1995	The intrastriatal injection of ET-1 promoted an increase of endogenous thiobarbituric reactive substances (TBARS), as index of free radical mediated lipid damage, and a greater susceptibility to iron/ascorbate-induced lipid peroxidation.	Iron	195-199	endothelin 1	Rattus norvegicus	31-35
7537177-6	1995	The presence of oxyradical scavengers i.e., albumin, catalase or superoxide dismutase significantly inhibited iron release from ferritin by BT.	Iron	110-114	catalase	Rattus norvegicus	53-61
7782907-0	1995	Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats.	Iron	78-82	transferrin	Rattus norvegicus	12-23
7782907-8	1995	This study extends previous research by demonstrating that the brain responds to changes in body iron status with a change in transferrin concentration.	Iron	97-101	transferrin	Rattus norvegicus	126-137
7782907-11	1995	The concept that iron enters the brain through a highly regulated endocytotic process at the blood brain barrier, that undoubtedly involves the regulation of transferrin receptors in capillary endothelial cell, is supported by our observation of elevated transferrin concentrations in brain of iron-deficient rats.	Iron	17-21	transferrin	Rattus norvegicus	158-169
7782907-11	1995	The concept that iron enters the brain through a highly regulated endocytotic process at the blood brain barrier, that undoubtedly involves the regulation of transferrin receptors in capillary endothelial cell, is supported by our observation of elevated transferrin concentrations in brain of iron-deficient rats.	Iron	17-21	transferrin	Rattus norvegicus	255-266
7782907-11	1995	The concept that iron enters the brain through a highly regulated endocytotic process at the blood brain barrier, that undoubtedly involves the regulation of transferrin receptors in capillary endothelial cell, is supported by our observation of elevated transferrin concentrations in brain of iron-deficient rats.	Iron	294-298	transferrin	Rattus norvegicus	158-169
7782907-11	1995	The concept that iron enters the brain through a highly regulated endocytotic process at the blood brain barrier, that undoubtedly involves the regulation of transferrin receptors in capillary endothelial cell, is supported by our observation of elevated transferrin concentrations in brain of iron-deficient rats.	Iron	294-298	transferrin	Rattus norvegicus	255-266
7567801-9	1995	The results strongly suggest, that the term syncytiotrophoblast is able to balance transferrin-mediated iron uptake and iron release.	Iron	104-108	transferrin	Homo sapiens	83-94
7766711-1	1995	The effect of congeners of nitrogen monoxide (NO) on iron (Fe) uptake from 59Fe-125I-transferrin (Tf) and release of 59Fe from prelabelled cells have been investigated in SK-MEL-28 human melanoma cells, human K562 cells and mouse MDW-4 cells.	Iron	53-57	transferrin	Homo sapiens	85-96
7766711-1	1995	The effect of congeners of nitrogen monoxide (NO) on iron (Fe) uptake from 59Fe-125I-transferrin (Tf) and release of 59Fe from prelabelled cells have been investigated in SK-MEL-28 human melanoma cells, human K562 cells and mouse MDW-4 cells.	Iron	59-61	transferrin	Homo sapiens	85-96
7665160-5	1995	CLCN3 protein also shows a high similarity with GEF1, an integral membrane protein of the yeast Saccharomyces cerevisiae known to be involved in respiration and iron-limited cell growth, and with the predicted protein product of a DNA sequence from the mold Septoria nodorum.	Iron	161-165	chloride channel, voltage-sensitive 3	Mus musculus	0-5
7720813-5	1995	Iron-deprivation produced a small increase in the endogenous expression of bcl-2 protein.	Iron	0-4	BCL2 apoptosis regulator	Homo sapiens	75-80
7537017-6	1995	In conclusion, iron deposition in sinusoidal cells and portal tracts is significantly less frequent in patients with complete response to IFN than in those with poor or no response, and may be a useful, objective predictor of response to IFN therapy.	Iron	15-19	interferon alpha 1	Homo sapiens	138-141
7579915-9	1995	These data support the contention that some radionuclides may cross the blood-testis barrier by utilisation of the physiologic iron-transferrin pathway, which may lead to greater testicular damage in adult compared to neonatal animals.	Iron	127-131	transferrin	Rattus norvegicus	132-143
7727409-1	1995	Human tyrosine hydroxylase isoform 1 (hTH1) was expressed in Escherichia coli, purified as the apoenzyme, and reconstituted with iron.	Iron	129-133	tyrosine hydroxylase	Homo sapiens	6-26
7748900-1	1995	The binding of 1-methylimidazole to the heme iron by displacing Met-80 of cytochrome c has been studied by two-dimensional (2D) exchange spectroscopy.	Iron	45-49	cytochrome c, somatic	Homo sapiens	74-86
7727512-0	1995	Modulation by iron loading and chelation of the uptake of non-transferrin-bound iron by human liver cells.	Iron	80-84	transferrin	Homo sapiens	62-73
7727512-1	1995	Hepatic non-transferrin-bound Fe (NTBI) flux and its regulation were characterized by measuring the uptake of Fe from [59Fe]/nitrilotriacetate (NTA) complexes in control and Fe-loaded cultures of human hepatocellular carcinoma cells (HepG2).	Iron	30-32	transferrin	Homo sapiens	12-23
7727512-8	1995	We conclude that HepG2 cells possess a transferrin-independent mechanism of Fe accumulation that responds reversibly to a regulatory intracellular Fe pool.	Iron	76-78	transferrin	Homo sapiens	39-50
7727512-8	1995	We conclude that HepG2 cells possess a transferrin-independent mechanism of Fe accumulation that responds reversibly to a regulatory intracellular Fe pool.	Iron	147-149	transferrin	Homo sapiens	39-50
7537017-1	1995	Recent evidence suggests that patients with chronic hepatitis C virus (CHCV) who respond to interferon-alpha (IFN) therapy have a lower hepatic iron concentration than those who do not.	Iron	144-148	interferon alpha 1	Homo sapiens	110-113
7537017-6	1995	In conclusion, iron deposition in sinusoidal cells and portal tracts is significantly less frequent in patients with complete response to IFN than in those with poor or no response, and may be a useful, objective predictor of response to IFN therapy.	Iron	15-19	interferon alpha 1	Homo sapiens	238-241
7786067-0	1995	Case study of the anemic patient: epoetin alfa--focus on iron management.	Iron	57-61	erythropoietin	Homo sapiens	34-41
7786067-2	1995	Despite ongoing educational efforts for health care professionals and patients, iron management remains a challenge for clinicians managing patients who receive Epoetin alfa therapy.	Iron	80-84	erythropoietin	Homo sapiens	161-168
7890373-1	1995	Haemophilus influenzae, a strict human pathogen, acquires iron in vivo through the direct binding and removal of iron from human transferrin by an as yet uncharacterized process at the bacterial cell surface.	Iron	58-62	transferrin	Homo sapiens	129-140
7549932-6	1995	Indeed, by using a cell-free system in which hexokinase Ia* was solubilized using Triton X-100, the decay in hexokinase activity induced by iron/ascorbate involved all three enzymatic forms.	Iron	140-144	hexokinase-2	Oryctolagus cuniculus	45-55
7549932-6	1995	Indeed, by using a cell-free system in which hexokinase Ia* was solubilized using Triton X-100, the decay in hexokinase activity induced by iron/ascorbate involved all three enzymatic forms.	Iron	140-144	hexokinase-2	Oryctolagus cuniculus	109-119
7633562-0	1995	NADPH-cytochrome-P450 reductase promotes hydroxyl radical production by the iron complex of ADR-925, the hydrolysis product of ICRF-187 (dexrazoxane).	Iron	76-80	cytochrome p450 oxidoreductase	Homo sapiens	0-31
7633562-3	1995	The ability of NADPH-cytochrome-P450 reductase to promote hydroxyl radical formation by iron complexes of ADR-925 and EDTA was compared by EPR spin trapping.	Iron	88-92	cytochrome p450 oxidoreductase	Homo sapiens	15-46
7655442-5	1995	Urinary IgA excretion in hypertensive patients was increased in association with increasing excretions of aluminum and/or iron into urine.	Iron	122-126	CD79a molecule	Homo sapiens	8-11
7705780-9	1995	Double-labeled (125I, 59Fe) transferrin was used to measure recovery of iron (Fe) relative to the protein (P) in bile.	Iron	72-76	transferrin	Rattus norvegicus	28-39
7890373-1	1995	Haemophilus influenzae, a strict human pathogen, acquires iron in vivo through the direct binding and removal of iron from human transferrin by an as yet uncharacterized process at the bacterial cell surface.	Iron	113-117	transferrin	Homo sapiens	129-140
7890373-7	1995	Loss of either Tbp2 or both proteins correlated with an inability to grow on media supplemented with transferrin-bound iron as the sole source of iron, whereas the Tbp1+ Tbp2- mutant was able to grow only at high transferrin concentrations.	Iron	119-123	transferrin	Homo sapiens	101-112
7706489-8	1995	At the molecular level, a total suppression of nonparenchymal cell proliferation was appreciable, although expression of collagen and TGF beta mRNAs was still present into microscopic iron-filled nonparenchymal cell aggregates scattered throughout the hepatic lobule.	Iron	184-188	transforming growth factor beta 1	Homo sapiens	134-142
7545199-10	1995	Serum ferritin and transferrin saturation only correlate with liver iron (r = 0.833 and r = 0.695, respectively, p = 0.00001); tissue iron is significantly higher in hepatitis C virus- than in hepatitis B virus-positive patients (p &lt; 0.05); 4.	Iron	68-72	transferrin	Homo sapiens	19-30
7542385-11	1995	CONCLUSIONS: (a) Individual features of lobular necrosis and iron staining in portal triads are better predictors of response to IFN-alpha than the total Knodell score.	Iron	61-65	interferon alpha 1	Homo sapiens	129-138
7490909-9	1995	After 4 months of iron supplementation, the hemoglobin, ferritin and transferrin saturation changed significantly in the iron deficient infants.	Iron	18-22	transferrin	Homo sapiens	69-80
7490909-9	1995	After 4 months of iron supplementation, the hemoglobin, ferritin and transferrin saturation changed significantly in the iron deficient infants.	Iron	121-125	transferrin	Homo sapiens	69-80
7554270-6	1995	These observations may be important, as the degree of sialylation of transferrin in serum and CSF plays a role in the homeostasis of iron, and suggest that alterations in transferrin sialylation may play a role in the pathophysiology of PD.	Iron	133-137	transferrin	Homo sapiens	69-80
7667902-4	1995	In all cases, iron acquisition from transferrin and haemoglobin required direct contact between the organisms and the proteins indicating the existence of specific receptors.	Iron	14-18	serotransferrin	Bos taurus	36-47
7667902-6	1995	These results indicate that the 93-99 kDa polypeptides are involved in the acquisition of iron from porcine transferrin and that the inability of strain K17 to use transferrin as an iron source is due, probably, to the lack of, or a defect in, an analogous component.	Iron	90-94	serotransferrin	Bos taurus	108-119
7788730-4	1995	TfR and Tf were mainly distributed in the peripheral part of the lobule (zone 1) in the normal, iron deficient and iron-overloaded rats.	Iron	96-100	transferrin	Rattus norvegicus	0-2
7720713-6	1995	These effects may be explained by the failure of iron to repress transcription of FRE1, FRE2 and FET3.	Iron	49-53	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	82-86
7783403-0	1995	Non-iron mediated alteration in hepatic transferrin gene expression in the nephrotic rat.	Iron	4-8	transferrin	Rattus norvegicus	40-51
7783403-2	1995	Patients may develop hypochromic microcytic anemia and synthesis of transferrin, a protein regulated in large part by iron availability, is increased.	Iron	118-122	transferrin	Homo sapiens	68-79
7720713-7	1995	FRE1 and FRE2 encode plasma membrane ferric reductases, obligatory for ferric iron assimilation, and FET3 encodes a copper-dependent membrane-associated oxidase required for ferrous iron uptake.	Iron	78-82	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-4
7720713-7	1995	FRE1 and FRE2 encode plasma membrane ferric reductases, obligatory for ferric iron assimilation, and FET3 encodes a copper-dependent membrane-associated oxidase required for ferrous iron uptake.	Iron	182-186	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-4
7773685-11	1995	The presence of TfBP in oligodendrocytes implies that this protein may play an important role in transferrin-mediated iron metabolism in the CNS.	Iron	118-122	transferrin	Homo sapiens	97-108
7890603-0	1995	Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.	Iron	111-115	iron responsive element binding protein 2	Homo sapiens	162-166
8614253-5	1995	Catalase is an iron containing enzyme which could potentially interact with the iron-binding groups of L-NAME.	Iron	15-19	catalase	Homo sapiens	0-8
8614253-5	1995	Catalase is an iron containing enzyme which could potentially interact with the iron-binding groups of L-NAME.	Iron	80-84	catalase	Homo sapiens	0-8
7788730-4	1995	TfR and Tf were mainly distributed in the peripheral part of the lobule (zone 1) in the normal, iron deficient and iron-overloaded rats.	Iron	115-119	transferrin	Rattus norvegicus	0-2
7788730-8	1995	In the iron-overloaded rats, the staining intensity of iron was stronger in zone 1 than in zone 2 and 3, similar to the distribution pattern of TfR and Tf.	Iron	7-11	transferrin	Rattus norvegicus	144-146
7788730-9	1995	These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats.	Iron	32-36	transferrin	Rattus norvegicus	98-100
7788730-9	1995	These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats.	Iron	32-36	transferrin	Rattus norvegicus	106-108
7867079-2	1995	We have examined the effect of iron in the form of ferric citrate on the CD4-lck and CD8-lck complexes in view of the key role played by the tyrosine kinase p56lck in regulating T-cell functions.	Iron	31-35	CD4 molecule	Homo sapiens	73-76
7893739-2	1995	When, after the initial preincubation with the chelators and prior to the addition of 3-methylmargaric acid, iron-saturated transferrin and Fe3+ were added, a partial restitution of the CO2-production rates was obtained.	Iron	109-113	transferrin	Rattus norvegicus	124-135
7741258-0	1995	The role of iron chelators and oxygen in the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P450 oxidoreductase-dependent chromium(VI) reduction.	Iron	12-16	cytochrome p450 oxidoreductase	Homo sapiens	97-127
7781256-7	1995	Iron supplements can be initiated as early as 2 weeks of age and high levels of intake appear to be necessary during erythropoietin therapy.	Iron	0-4	erythropoietin	Homo sapiens	117-131
7872321-0	1995	Efficacy of oral iron therapy in patients receiving recombinant human erythropoietin.	Iron	17-21	erythropoietin	Homo sapiens	70-84
7872321-1	1995	Iron supplementation is required by most dialysis patients receiving recombinant human erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	87-101
7872321-2	1995	The efficacy of oral iron is variable in these patients, and many require the use of intravenous iron dextran to maintain adequate iron levels, defined as transferrin saturation greater than 20%, serum ferritin greater than 100 ng/mL, and serum iron greater than 80 micrograms/dL.	Iron	97-101	transferrin	Homo sapiens	155-166
7872321-2	1995	The efficacy of oral iron is variable in these patients, and many require the use of intravenous iron dextran to maintain adequate iron levels, defined as transferrin saturation greater than 20%, serum ferritin greater than 100 ng/mL, and serum iron greater than 80 micrograms/dL.	Iron	97-101	transferrin	Homo sapiens	155-166
7550090-0	1995	Nonenzymatic glycation of transferrin: decrease of iron-binding capacity and increase of oxygen radical production.	Iron	51-55	transferrin	Rattus norvegicus	26-37
7550090-10	1995	These results suggest that iron ions in the glycated transferrin molecule are bound loosely to the protein and are redox-active and the glycated holotransferrin produces oxygen radicals including O2- and OH.	Iron	27-31	transferrin	Rattus norvegicus	53-64
7773198-0	1995	An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum.	Iron	81-85	transferrin	Homo sapiens	63-74
7773198-1	1995	A simple method for direct quantitation of non-transferrin-bound iron (NTBI) in serum is introduced.	Iron	65-69	transferrin	Homo sapiens	47-58
7867079-0	1995	Iron differentially modulates the CD4-lck and CD8-lck complexes in resting peripheral blood T-lymphocytes.	Iron	0-4	CD4 molecule	Homo sapiens	34-37
7867079-6	1995	Furthermore, flow cytometry analysis showed a decrease in the surface expression of the CD4 molecule in iron-treated PBLs, as judged by a decrease in the mean fluorescence intensity (MFI), that was accompanied by a decrease in the percentage of CD4+ T-lymphocytes.	Iron	104-108	CD4 molecule	Homo sapiens	88-91
7867079-6	1995	Furthermore, flow cytometry analysis showed a decrease in the surface expression of the CD4 molecule in iron-treated PBLs, as judged by a decrease in the mean fluorescence intensity (MFI), that was accompanied by a decrease in the percentage of CD4+ T-lymphocytes.	Iron	104-108	CD4 molecule	Homo sapiens	245-248
7867079-8	1995	This differential effect of ferric citrate on the CD4+ and CD8+ T-cell subsets led to a marked decrease in the CD4/CD8 ratios in iron-treated PBLs after the 20- to 24-hr period (P &lt; 0.001).	Iron	129-133	CD4 molecule	Homo sapiens	50-53
7867079-8	1995	This differential effect of ferric citrate on the CD4+ and CD8+ T-cell subsets led to a marked decrease in the CD4/CD8 ratios in iron-treated PBLs after the 20- to 24-hr period (P &lt; 0.001).	Iron	129-133	CD4 molecule	Homo sapiens	111-114
7705333-3	1995	Unlike mammalian transferrin, the similarity between its N-terminal and C-terminal halves was only 19%, and it was suggested to conjugate one iron atom/molecule in its N-terminal half.	Iron	142-146	transferrin	Homo sapiens	17-28
7705333-4	1995	Sarcophaga transferrin was found to transport iron ions into eggs during oogenesis and deliver them to another protein, thought to be ferritin.	Iron	46-50	transferrin	Homo sapiens	11-22
7861129-4	1995	This inhibitor of ET-1 production was purified by gel-exclusion and ion-exchange chromatography as a 280-Da iron-containing molecule, able to release nitrites upon degradation.	Iron	108-112	endothelin 1	Rattus norvegicus	18-22
7774536-7	1995	RESULTS: With increasing iron requirements there was an increase in iron absorption, and a decrease in serum ferritin concentration and transferrin saturation.	Iron	25-29	transferrin	Homo sapiens	136-147
7665066-0	1995	[Anemia in puerperium; parenteral iron substitution renders erythropoietin therapy dispensable].	Iron	34-38	erythropoietin	Homo sapiens	60-74
7861129-5	1995	These results suggest that astrocytes, via release of an iron-nitrogen oxide complex, may be involved in a regulatory loop of ET-1 production at the level of the blood-brain barrier.	Iron	57-61	endothelin 1	Rattus norvegicus	126-130
7787990-0	1995	Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats.	Iron	79-83	transferrin	Rattus norvegicus	0-11
7787990-8	1995	The staining intensity of TfR, Tf and Ft increased in hepatocytes of iron-deficient rats and decreased in that of the iron-overloaded in comparison with the control rats.	Iron	69-73	transferrin	Rattus norvegicus	26-28
7787990-8	1995	The staining intensity of TfR, Tf and Ft increased in hepatocytes of iron-deficient rats and decreased in that of the iron-overloaded in comparison with the control rats.	Iron	118-122	transferrin	Rattus norvegicus	26-28
7871382-1	1995	A supply of iron is of vital importance if lymphocyte proliferation is to proceed successfully and two major sources of iron are available, intracellular stores and serum transferrin.	Iron	12-16	transferrin	Homo sapiens	171-182
7873545-1	1995	In either sperm whale or horse heart myoglobin, binding of NO and lowering of solution pH work together to weaken, and ultimately break, the bond between iron and the proximal histidine.	Iron	154-158	myoglobin	Equus caballus	37-46
7871382-5	1995	We also observed that transferrin receptor mRNA expression was sustained in mitogen-stimulated, iron-deprived lymphocytes, compared with untreated cells suggesting that up-regulation of transferrin receptor may occur in these cells through stabilization of the mRNA.	Iron	96-100	transferrin	Homo sapiens	22-33
7871382-5	1995	We also observed that transferrin receptor mRNA expression was sustained in mitogen-stimulated, iron-deprived lymphocytes, compared with untreated cells suggesting that up-regulation of transferrin receptor may occur in these cells through stabilization of the mRNA.	Iron	96-100	transferrin	Homo sapiens	186-197
7864645-5	1995	The released iron may promote microsomal phospholipid peroxidation in the presence of endogenous ascorbate or NADPH-dependent cytochrome P-450 reductase because ascorbate oxidase and p-chloromercuribenzoic acid (an inhibitor of sulfhydryl enzymes) inhibited metHb- or HbO2-induced lipid peroxidation.	Iron	13-17	cytochrome p450 oxidoreductase	Homo sapiens	110-152
7864799-7	1995	The transferrin receptor is normally a homodimer that is involved in the internalization of iron-bound transferrin into cells and can be expressed at relatively high levels in the cell lines which we have studied.	Iron	92-96	transferrin	Homo sapiens	4-15
7864799-7	1995	The transferrin receptor is normally a homodimer that is involved in the internalization of iron-bound transferrin into cells and can be expressed at relatively high levels in the cell lines which we have studied.	Iron	92-96	transferrin	Homo sapiens	103-114
7531396-1	1995	In nephrotic syndrome, iron is presented to the tubule fluid in a nonreactive form in association with transferrin as a result of the glomerular protein leak.	Iron	23-27	transferrin	Homo sapiens	103-114
7531396-2	1995	At an alkaline pH, iron remains bound to transferrin throughout the nephron and is excreted as such in the urine.	Iron	19-23	transferrin	Homo sapiens	41-52
7531396-6	1995	This non-transferrin-bound iron is capable of catalyzing bleomycin degradation of DNA, suggesting that this labile form of iron is able to catalyze free radical formation and cause tubule cell injury.	Iron	27-31	transferrin	Homo sapiens	9-20
7531396-6	1995	This non-transferrin-bound iron is capable of catalyzing bleomycin degradation of DNA, suggesting that this labile form of iron is able to catalyze free radical formation and cause tubule cell injury.	Iron	123-127	transferrin	Homo sapiens	9-20
7885270-5	1995	In both thalassemic groups, SI was reduced by approximately 40% (3.52 +/- 0.57 and 3.74 +/- 0.66 v 6.89 +/- 1.02 10(-4).min-1 [microU/mL], P = .011) and was inversely correlated with iron overload (r = -.707, P = .006).	Iron	183-187	CD59 molecule (CD59 blood group)	Homo sapiens	120-125
8529864-8	1995	One of them is related to catalytic action of iron and ascorbate, while the other to an enzyme, possibly phospholipase A2, as has been suggested by some investigators.	Iron	46-50	phospholipase A2 group IB	Homo sapiens	105-121
7766029-7	1995	The transferrin saturation with iron was significantly greater in SeD rats than in SeA rats (57-60% versus 30-31%).	Iron	32-36	transferrin	Rattus norvegicus	4-15
7822047-0	1995	Utilization of transferrin-bound iron by Haemophilus influenzae requires an intact tonB gene.	Iron	33-37	transferrin	Homo sapiens	15-26
7822047-1	1995	Haemophilus influenzae can utilize iron-loaded human transferrin as an iron source for growth in vitro.	Iron	35-39	transferrin	Homo sapiens	53-64
7822047-1	1995	Haemophilus influenzae can utilize iron-loaded human transferrin as an iron source for growth in vitro.	Iron	71-75	transferrin	Homo sapiens	53-64
7822047-2	1995	H. influenzae tonB mutants, containing a chloramphenicol acetyltransferase gene within their tonB genes, could bind iron-charged human transferrin to their cell surfaces, but they were unable to utilize this serum glycoprotein as the sole source of iron for growth in vitro.	Iron	116-120	transferrin	Homo sapiens	135-146
7822047-4	1995	Transformation of a tonB mutant with a plasmid encoding a wild-type H. influenzae tonB gene restored the ability of a tonB mutant to utilize iron-charged human transferrin.	Iron	141-145	transferrin	Homo sapiens	160-171
7822047-5	1995	These results indicate that the uptake of iron from human transferrin by H. influenzae is a TonB-dependent process.	Iron	42-46	transferrin	Homo sapiens	58-69
7529879-3	1995	Pretreatment with the iron chelator desferroxamine followed by hydrogen peroxide treatment at 37 degrees C gives a considerable sparing effect, which is substantially greater for the LY-R subline than for the LY-S subline.	Iron	22-26	lymphoma resistance	Mus musculus	183-187
7745107-0	1995	Changes in transferrin saturation after treatment with the oral iron chelator deferiprone in patients with iron overload.	Iron	64-68	transferrin	Homo sapiens	11-22
7745107-0	1995	Changes in transferrin saturation after treatment with the oral iron chelator deferiprone in patients with iron overload.	Iron	107-111	transferrin	Homo sapiens	11-22
7745107-1	1995	AIMS: To evaluate the changes in transferrin saturation in patients with iron overload following the oral administration of the iron chelator deferiprone; to assess the correlation between the degree of transferrin desaturation, the deferiprone dose, and urinary iron excretion.	Iron	73-77	transferrin	Homo sapiens	33-44
7745107-1	1995	AIMS: To evaluate the changes in transferrin saturation in patients with iron overload following the oral administration of the iron chelator deferiprone; to assess the correlation between the degree of transferrin desaturation, the deferiprone dose, and urinary iron excretion.	Iron	128-132	transferrin	Homo sapiens	33-44
7861256-1	1995	While there are reports that classical selenium-dependent glutathione peroxidase (Se-GPX1) activity is decreased during iron deficiency, the relationship between tissue iron status and Se-GPX1 activity remains speculative.	Iron	120-124	glutathione peroxidase 1	Rattus norvegicus	85-89
7745107-1	1995	AIMS: To evaluate the changes in transferrin saturation in patients with iron overload following the oral administration of the iron chelator deferiprone; to assess the correlation between the degree of transferrin desaturation, the deferiprone dose, and urinary iron excretion.	Iron	128-132	transferrin	Homo sapiens	33-44
7745107-4	1995	This method is able to resolve serum transferrin into four different forms (free iron, two forms of monoferric, and diferric).	Iron	81-85	transferrin	Homo sapiens	37-48
7745107-9	1995	This was associated with a maximum rise in the percentage of iron free transferrin (apotransferrin) from 2.9 (7.0)% to 27.3 (17.8)%.	Iron	61-65	transferrin	Homo sapiens	71-82
7745107-10	1995	The total amount of iron estimated to be removed from transferrin constituted 21.3 (20.2)% of the 24 hour urinary iron excretion measured during the study.	Iron	20-24	transferrin	Homo sapiens	54-65
7745107-10	1995	The total amount of iron estimated to be removed from transferrin constituted 21.3 (20.2)% of the 24 hour urinary iron excretion measured during the study.	Iron	114-118	transferrin	Homo sapiens	54-65
7745107-12	1995	CONCLUSIONS: The results confirm that deferiprone can remove iron from transferrin when administered orally to patients with iron overload and that transferrin bound iron may, therefore, be a significant source of the iron chelated by deferiprone in vivo.	Iron	61-65	transferrin	Homo sapiens	71-82
7618648-0	1995	Iron metabolism indices for early prediction of the response and resistance to erythropoietin therapy in maintenance hemodialysis patients.	Iron	0-4	erythropoietin	Homo sapiens	79-93
7485807-3	1995	Iron status was assessed by using multiple criteria--iron in serum, TIBC, transferrin saturation capacity and hemoglobin level.	Iron	0-4	transferrin	Homo sapiens	74-85
7851403-1	1995	A seven-iron ferredoxin was isolated from aerobically grown cells of the hyperthermoacidophilic archaeon Desulfurolobus ambivalens (DSM 3772).	Iron	8-12	ATZ20_RS09870	Sulfolobus acidocaldarius	13-23
7814363-2	1995	This reductase is required for Fe(III) uptake by this yeast; transcription from FRE1 is repressed by iron (Dancis, A., Klausner, R. D., Hinnebusch, A. G., and Barriocanal, J. G. (1990) Mol.	Iron	101-105	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	80-84
8527220-5	1995	Conversely, iron-containing molecules affect expression of mitochondrial aconitase, erythroid aminolevulinic acid synthase, and nitric oxide synthase.	Iron	12-16	aconitase 2	Homo sapiens	59-82
8597311-3	1995	At the same time, these two inflammations induce in plasma: a significant increase in ceruloplasmin (respectively 70 and 42%); a decrease in iron transferrin (48 and 53%) and iron saturation (%) of transferrin (53 and 68%); an increase in the protein level of 45% for croton oil treated animals.	Iron	141-145	transferrin	Rattus norvegicus	146-157
8597311-3	1995	At the same time, these two inflammations induce in plasma: a significant increase in ceruloplasmin (respectively 70 and 42%); a decrease in iron transferrin (48 and 53%) and iron saturation (%) of transferrin (53 and 68%); an increase in the protein level of 45% for croton oil treated animals.	Iron	175-179	transferrin	Rattus norvegicus	198-209
7762965-6	1995	In the serum, iron is carried by transferrin.	Iron	14-18	transferrin	Homo sapiens	33-44
7762965-11	1995	Intracellular iron concentration regulates the synthesis of ferritin, transferrin receptor, and eALAS, thus controlling our iron metabolism.	Iron	14-18	transferrin	Homo sapiens	70-81
7762965-11	1995	Intracellular iron concentration regulates the synthesis of ferritin, transferrin receptor, and eALAS, thus controlling our iron metabolism.	Iron	124-128	transferrin	Homo sapiens	70-81
7768243-2	1995	Physical exercise (10 min on a cycle ergometer at a heart rate of 150 beats.min-1) induced a significant increase in total leucocyte, lymphocyte and neutrophil concentrations in active subjects; serum iron and ferritin concentrations were lower in active compared to inactive subjects.	Iron	201-205	CD59 molecule (CD59 blood group)	Homo sapiens	76-81
7662812-7	1995	Iron-binding status also determined the effect of lactoferrin and transferrin on cellular differentiation, but this effect differed for different brush border enzymes.	Iron	0-4	transferrin	Homo sapiens	66-77
7662812-11	1995	Lactoferrin and transferrin may modulate the proliferation and differentiation of intestinal epithelial cells, but their efficacy depends on their saturation with iron.	Iron	163-167	transferrin	Homo sapiens	16-27
7728656-0	1995	Contact-dependent acquisition of transferrin-bound iron by two strains of Haemophilus parasuis.	Iron	51-55	serotransferrin	Bos taurus	33-44
7728656-2	1995	Both strains produced iron-repressible outer membrane proteins and could acquire iron from porcine transferrin but not from porcine lactoferrin.	Iron	22-26	serotransferrin	Bos taurus	99-110
7728656-2	1995	Both strains produced iron-repressible outer membrane proteins and could acquire iron from porcine transferrin but not from porcine lactoferrin.	Iron	81-85	serotransferrin	Bos taurus	99-110
7728656-4	1995	In all cases, iron acquisition from transferrin required direct contact between the organisms and the protein.	Iron	14-18	serotransferrin	Bos taurus	36-47
7728656-5	1995	An affinity isolation technique based on biotinylated porcine transferrin plus streptavidin-agarose, followed by SDS-PAGE, allowed the isolation and identification of two potential porcine transferrin binding polypeptides (94 and 60 kDa) from total membranes derived from the type strain grown under iron-restricted conditions but only one (96 kDa) from strain E751.	Iron	300-304	serotransferrin	Bos taurus	189-200
7728656-7	1995	It is concluded that both strains acquire transferrin-bound iron by means of siderophore-independent mechanisms and that the isolated polypeptides represent porcine transferrin receptor components.	Iron	60-64	serotransferrin	Bos taurus	42-53
7744374-5	1995	The damage of iron-loaded hepatocytes induced by CCl4 was more serious than that of control, and HGF decreased this injury only in iron-loaded hepatocytes but not in control.	Iron	14-18	C-C motif chemokine ligand 4	Rattus norvegicus	49-53
7768775-2	1995	The presence of a leishmania transferrin receptor on the parasite suggests that an adequate supply of iron is needed for the life cycle of leishmania.	Iron	102-106	transferrin	Homo sapiens	29-40
7894712-0	1995	Staphylococcus aureus but not Staphylococcus epidermidis can acquire iron from transferrin.	Iron	69-73	transferrin	Homo sapiens	79-90
7829975-0	1995	LPS inhibits the intracellular growth of Legionella pneumophila in thioglycolate elicited murine peritoneal macrophages by iron-dependent, tryptophan-independent, oxygen-independent, and arginine-independent mechanisms.	Iron	123-127	toll-like receptor 4	Mus musculus	0-3
7829975-3	1995	LPS activation of murine macrophages induced a downshift in transferrin receptor (TfR) expression and reduction in cellular iron content, and this was correlated with augmented intracellular growth of Legionella in the cells.	Iron	124-128	toll-like receptor 4	Mus musculus	0-3
7829975-4	1995	When LPS-stimulated macrophages were first saturated with iron, partial reversion of L. pneumophila growth restriction was observed.	Iron	58-62	toll-like receptor 4	Mus musculus	5-8
7798927-0	1995	Iron levels modulate alpha-secretase cleavage of amyloid precursor protein.	Iron	0-4	amyloid beta precursor protein	Homo sapiens	49-74
7829975-8	1995	Thus, we conclude that LPS-activated macrophages inhibit the intracellular growth of L. pneumophila partially by iron-dependent, Trp-independent, and ROI- and RNI-independent mechanisms.	Iron	113-117	toll-like receptor 4	Mus musculus	23-26
7876832-0	1995	Release of iron from C-terminal monoferric transferrin to phosphate and pyrophosphate at pH 5.5 proceeds through two pathways.	Iron	11-15	transferrin	Homo sapiens	43-54
7876832-1	1995	Iron release fro C-terminal monoferric transferrin at pH 5.5 and 37 degrees C was studied as a function of chloride, phosphate, and pyrophosphate concentration.	Iron	0-4	transferrin	Homo sapiens	39-50
7876832-7	1995	The qualitative similarity of the current data with that recently reported for iron release from the transferrin-transferrin receptor complex provides strong support for the contention that the two-pathway mechanism also persists in this complex at low pH and is hence likely to be operative in vivo.	Iron	79-83	transferrin	Homo sapiens	101-112
7876832-7	1995	The qualitative similarity of the current data with that recently reported for iron release from the transferrin-transferrin receptor complex provides strong support for the contention that the two-pathway mechanism also persists in this complex at low pH and is hence likely to be operative in vivo.	Iron	79-83	transferrin	Homo sapiens	113-124
7658318-6	1995	The single largest demand for iron arises from the increased red cell mass under the influence of erythropoietin.	Iron	30-34	erythropoietin	Homo sapiens	98-112
7658327-1	1995	Our aim was to correct severe iron deficiency anemia during pregnancy by using a combination therapy of recombinant human erythropoietin and parenteral iron.	Iron	30-34	erythropoietin	Homo sapiens	122-136
7658327-4	1995	Iron status was assessed by serum ferritin values and transferrin saturation values.	Iron	0-4	transferrin	Homo sapiens	54-65
7753436-5	1995	3) transferrin receptor route, very important for cellular uptake of iron and zinc.	Iron	69-73	transferrin	Rattus norvegicus	3-14
7894712-3	1995	To determine if staphylococci can extract iron bound to human transferrin, we labelled transferrin with 55Fe and performed uptake assays on cells grown in iron-restricted and iron-plentiful conditions.	Iron	42-46	transferrin	Homo sapiens	62-73
7894712-8	1995	This difference in the ability to acquire iron bound to transferrin may contribute to the increased virulence of S. aureus when compared to S. epidermidis.	Iron	42-46	transferrin	Homo sapiens	56-67
7644109-1	1995	The most common cause of limited response to recombinant human erythropoietin (r-HuEPO) is unrecognized, mild-to-moderate iron deficiency, either at the start of treatment or secondary to enhanced iron utilization by newly formed erythrocytes.	Iron	122-126	erythropoietin	Homo sapiens	63-77
7777104-6	1995	Similarly a decreased SOD activity was observed as compared to group 1 (p &lt; 0.001), indicating its inactivation subsequent to an hyperproduction of reactive oxygen species through iron injection.	Iron	183-187	superoxide dismutase 1	Homo sapiens	22-25
8524494-0	1995	Resistance to erythropoietin in iron-overloaded haemodialysis patients can be overcome by ascorbic acid administration.	Iron	32-36	erythropoietin	Homo sapiens	14-28
7644112-12	1995	Effective and regular monitoring of iron status by measurement of serum ferritin, transferrin saturation, and per cent hypochromic red cells is critical to the management of the patient receiving r-HuEPO, and there is increasing evidence that liberal use of i.v.	Iron	36-40	transferrin	Homo sapiens	82-93
8524494-1	1995	Haemodialysis patients with iron overload sometimes develop resistance to erythropoietin therapy due to "functional iron deficiency".	Iron	28-32	erythropoietin	Homo sapiens	74-88
8524494-10	1995	We conclude that ascorbate supplementation may circumvent resistance to erythropoietin that sometimes occurs in iron-overloaded patients, in particular, in the setting of "functional iron deficiency".	Iron	112-116	erythropoietin	Homo sapiens	72-86
7644113-1	1995	Inadequate iron supply is probably the most common and most easily treated cause of sub-optimal response to recombinant human erythropoietin (r-HuEPO).	Iron	11-15	erythropoietin	Homo sapiens	126-140
7644113-6	1995	Iron supplementation should be targeted at keeping serum ferritin &gt; 100 micrograms/l, transferrin saturation &gt; 20%, and hypochromic red cells &lt; 10%.	Iron	0-4	transferrin	Homo sapiens	89-100
8834628-1	1995	The serum lysozyme level of workers engaged in the production of iron-manganese alloys was observed.	Iron	65-69	lysozyme	Homo sapiens	10-18
7644679-0	1995	[Iron metabolism in patients treated with erythropoietin].	Iron	1-5	erythropoietin	Homo sapiens	42-56
7528206-11	1994	In contrast, CaM"s activation of NO synthesis and substrate-independent NADPH oxidation appeared to involve flavin-to-heme electron transfer because these reactions were not activated in apo-NOS and were blocked in native NOS by agents that prevent heme iron reduction.	Iron	254-258	calmodulin 1	Homo sapiens	13-16
7999759-5	1994	Two recent structure reports provided conflicting views about the participation of the side chain of asparagine-694 in the coordination of the iron atom required for catalysis by lipoxygenase 1.	Iron	143-147	seed linoleate 13S-lipoxygenase-1	Glycine max	179-193
7999760-0	1994	X-ray spectroscopy of the iron site in soybean lipoxygenase-1: changes in coordination upon oxidation or addition of methanol.	Iron	26-30	seed linoleate 13S-lipoxygenase-1	Glycine max	47-61
7999760-1	1994	Iron K-edge X-ray spectroscopy (XANES and EXAFS) was used to study iron coordination in frozen solutions of soybean lipoxygenase-1 (SLO).	Iron	0-4	seed linoleate 13S-lipoxygenase-1	Glycine max	116-130
7999760-1	1994	Iron K-edge X-ray spectroscopy (XANES and EXAFS) was used to study iron coordination in frozen solutions of soybean lipoxygenase-1 (SLO).	Iron	67-71	seed linoleate 13S-lipoxygenase-1	Glycine max	116-130
7999768-0	1994	Rapid kinetics of the EPR-active species formed during initial iron uptake in horse spleen apoferritin.	Iron	63-67	ferritin heavy chain	Equus caballus	91-102
7827010-5	1994	However, consistent with the suppressed DTH response in the Fe-deficient mice was the suppressed concanavalin A-induced T-lymphocyte blastogenesis and the interferon-gamma (INF-gamma) production by spleen cells from mice fed on the Fe-deficient diet.	Iron	60-62	interferon gamma	Mus musculus	155-171
7983023-0	1994	Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2.	Iron	39-43	iron responsive element binding protein 2	Homo sapiens	80-105
7983023-9	1994	In most cell lines tested, levels of IRP2 are inversely regulated by iron levels due to iron-dependent regulation of the half-life of the protein.	Iron	69-73	iron responsive element binding protein 2	Homo sapiens	37-41
7983023-9	1994	In most cell lines tested, levels of IRP2 are inversely regulated by iron levels due to iron-dependent regulation of the half-life of the protein.	Iron	88-92	iron responsive element binding protein 2	Homo sapiens	37-41
7697000-0	1994	Plasma 4-hydroxy-2-nonenal levels during cardiopulmonary bypass, and their relationship to the iron-loading of transferrin.	Iron	95-99	transferrin	Homo sapiens	111-122
7697000-4	1994	During bypass iron is released often saturating plasma transferrin, and resulting in the appearance of chelatable iron in the plasma.	Iron	14-18	transferrin	Homo sapiens	55-66
7697000-6	1994	Our results show a greater percentage increase in HNE formation during bypass when the plasma transferrin is iron-overloaded compared with matched controls not showing iron-overload.	Iron	109-113	transferrin	Homo sapiens	94-105
7697000-6	1994	Our results show a greater percentage increase in HNE formation during bypass when the plasma transferrin is iron-overloaded compared with matched controls not showing iron-overload.	Iron	168-172	transferrin	Homo sapiens	94-105
7811087-3	1994	Two different types of purple bacteria, represented by strains L7 and SW2, were isolated which oxidized colorless ferrous iron under anoxic conditions in the light to brown ferric iron.	Iron	114-126	WD repeat domain 82 pseudogene 1	Homo sapiens	70-73
7827010-5	1994	However, consistent with the suppressed DTH response in the Fe-deficient mice was the suppressed concanavalin A-induced T-lymphocyte blastogenesis and the interferon-gamma (INF-gamma) production by spleen cells from mice fed on the Fe-deficient diet.	Iron	60-62	interferon gamma	Mus musculus	173-182
7827010-6	1994	Spleen cells from mice fed on excess levels of Fe in the diet secreted less INF-gamma than the control mice, although T-lymphocyte proliferation remained unaffected.	Iron	47-49	interferon gamma	Mus musculus	76-85
7759148-0	1994	Iron administration during erythropoietin therapy in hemodialysis patients.	Iron	0-4	erythropoietin	Homo sapiens	27-41
7756973-5	1994	A key factor in the inhibitory effect of IL-1 beta and TNF in rat islets is the generation of nitric oxide which inactivates enzymes such as aconitase and ribonucleotide reductase by formation of iron-nitrosyl complexes.	Iron	196-200	interleukin 1 beta	Rattus norvegicus	41-50
7756973-5	1994	A key factor in the inhibitory effect of IL-1 beta and TNF in rat islets is the generation of nitric oxide which inactivates enzymes such as aconitase and ribonucleotide reductase by formation of iron-nitrosyl complexes.	Iron	196-200	tumor necrosis factor	Rattus norvegicus	55-58
7974509-4	1994	Both NADPH- and NADH-dependent cytochrome c reductases were slightly decreased after iron overload, but cytochrome P450 was undetectable after 6 h of iron supplementation.	Iron	150-154	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	104-119
7715446-0	1994	Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens.	Iron	0-4	transferrin	Homo sapiens	28-39
7715446-0	1994	Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens.	Iron	46-50	transferrin	Homo sapiens	28-39
7715446-1	1994	The mechanism of iron utilization from transferrin has been most extensively characterized in the pathogenic Neisseria species and Haemophilus species.	Iron	17-21	transferrin	Homo sapiens	39-50
7715446-4	1994	The relative contribution of each of these proteins to transferrin binding and utilization is discussed and a model of iron uptake from transferrin is presented.	Iron	119-123	transferrin	Homo sapiens	136-147
7751970-3	1994	Peak 1 was a membrane iron-binding complex whose apparent molecular weight was over 10(6) Da estimated by gel filtration, while peak 2 was identified as ferritin.	Iron	22-26	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	0-6
7751970-6	1994	Incorporation of 59Fe to peak 1 showed the maximum at 1 h and then reduced, while [59Fe]ferritin showed reciprocal behavior, which suggested that peak 1 may be a rapid turnover iron pool and transfer 59Fe to ferritin.	Iron	177-181	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	146-152
7751970-9	1994	Those findings suggest that peak 1 may be a non-ferritin, non-transferrin iron-binding complex located on the brush border membrane and accept iron from the intestinal canal during iron absorption.	Iron	74-78	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	28-34
7751970-9	1994	Those findings suggest that peak 1 may be a non-ferritin, non-transferrin iron-binding complex located on the brush border membrane and accept iron from the intestinal canal during iron absorption.	Iron	143-147	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	28-34
7751970-9	1994	Those findings suggest that peak 1 may be a non-ferritin, non-transferrin iron-binding complex located on the brush border membrane and accept iron from the intestinal canal during iron absorption.	Iron	143-147	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	28-34
9423132-2	1994	Single doses of 6000, 12,000, 18,000 and 24,000 unit (IU) of EPO with intravenous iron (40 mg) were administered once a week for 3 weeks with ABP (400 ml/week) before surgery.	Iron	82-86	erythropoietin	Homo sapiens	61-64
7974509-10	1994	The inactivation of nuclear cytochrome P450, the significant loss in lipid-soluble antioxidants (alpha-tocopherol and beta-carotene) and the decrease in enzyme-dependent oxygen radical generation, suggest that the increase in catalytic active iron induced by iron overload could affect the cellular nuclei functionality.	Iron	243-247	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	28-43
7974509-10	1994	The inactivation of nuclear cytochrome P450, the significant loss in lipid-soluble antioxidants (alpha-tocopherol and beta-carotene) and the decrease in enzyme-dependent oxygen radical generation, suggest that the increase in catalytic active iron induced by iron overload could affect the cellular nuclei functionality.	Iron	259-263	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	28-43
7942787-9	1994	Recent speculation postulates that tumor necrosis factor may be involved in the etiology of this disease because of its location on chromosome 6 and its effect upon iron transport.	Iron	165-169	tumor necrosis factor	Homo sapiens	35-56
7947682-4	1994	While evolutionarily divergent, iron binding by all described transferrin lobes is accomplished by a remarkably similar repertoire of residues, including two Tyr, one His, and one Asp, as well as a synergestic bicarbonate anion.	Iron	32-36	transferrin	Homo sapiens	62-73
7533708-1	1994	The aim of the present study was to investigate the combined effect of tin (SnCl2) and lead Pb(CH3COO)2 on activity of heme biosynthesis enzymes [delta-aminolevulinic acid synthetase (ALA-S) and heme oxygenase] in liver and kidneys, as well as iron (Fe) and copper (Cu) concentration in serum of rats.	Iron	244-248	5'-aminolevulinate synthase 1	Rattus norvegicus	146-182
7533708-1	1994	The aim of the present study was to investigate the combined effect of tin (SnCl2) and lead Pb(CH3COO)2 on activity of heme biosynthesis enzymes [delta-aminolevulinic acid synthetase (ALA-S) and heme oxygenase] in liver and kidneys, as well as iron (Fe) and copper (Cu) concentration in serum of rats.	Iron	244-248	5'-aminolevulinate synthase 1	Rattus norvegicus	184-189
7533708-1	1994	The aim of the present study was to investigate the combined effect of tin (SnCl2) and lead Pb(CH3COO)2 on activity of heme biosynthesis enzymes [delta-aminolevulinic acid synthetase (ALA-S) and heme oxygenase] in liver and kidneys, as well as iron (Fe) and copper (Cu) concentration in serum of rats.	Iron	250-252	5'-aminolevulinate synthase 1	Rattus norvegicus	146-182
7533708-1	1994	The aim of the present study was to investigate the combined effect of tin (SnCl2) and lead Pb(CH3COO)2 on activity of heme biosynthesis enzymes [delta-aminolevulinic acid synthetase (ALA-S) and heme oxygenase] in liver and kidneys, as well as iron (Fe) and copper (Cu) concentration in serum of rats.	Iron	250-252	5'-aminolevulinate synthase 1	Rattus norvegicus	184-189
7977754-0	1994	TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload.	Iron	102-106	transforming growth factor, beta 1	Rattus norvegicus	0-8
7977754-4	1994	Iron overload stimulated the expression of the cytokine transforming growth factor-beta (TGF-beta) in acinar zone 1, in spite of the minor degree of hepatocellular necrosis and inflammation.	Iron	0-4	transforming growth factor, beta 1	Rattus norvegicus	89-97
7977754-5	1994	The formation of reactive aldehydes and TGF-beta, both inducers of collagen gene expression, may play a role in the stimulation of hepatic collagen production in iron overload.	Iron	162-166	transforming growth factor, beta 1	Rattus norvegicus	40-48
7881986-0	1994	Monitoring of iron status and iron supplementation in patients treated with erythropoietin.	Iron	14-18	erythropoietin	Homo sapiens	76-90
7881986-0	1994	Monitoring of iron status and iron supplementation in patients treated with erythropoietin.	Iron	30-34	erythropoietin	Homo sapiens	76-90
7881986-1	1994	Patients receiving erythropoietin therapy require large quantities of iron to keep pace with the demands of the bone marrow during active erythropoiesis.	Iron	70-74	erythropoietin	Homo sapiens	19-33
7896207-5	1994	Two of these patients also developed a functional iron deficiency while on treatment, as documented by an increase in HE, despite normal serum iron, transferrin saturation and even very high levels of ferritin.	Iron	50-54	transferrin	Homo sapiens	149-160
9738208-6	1994	In plasma, 80-90% of aluminum binds to transferrin, an iron-transport protein for which receptors exist in many tissue.	Iron	55-59	transferrin	Homo sapiens	39-50
7896207-6	1994	They needed iron supplementation to maintain the response to r-EPO.	Iron	12-16	erythropoietin	Homo sapiens	63-66
7927771-0	1994	Growth of Moraxella catarrhalis with human transferrin and lactoferrin: expression of iron-repressible proteins without siderophore production.	Iron	86-90	transferrin	Homo sapiens	43-54
7927758-0	1994	Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin.	Iron	109-113	transferrin	Homo sapiens	114-125
7860083-6	1994	The new polymorphisms of the transferrin receptor gene may be useful markers in population and linkage studies and in studies of associations with body iron stores and susceptibility to genotoxic damage and cancer.	Iron	152-156	transferrin	Homo sapiens	29-40
7927771-2	1994	In this study, we investigated whether M. catarrhalis can compete for iron bound to human transferrin or human lactoferrin in a manner similar to that utilized by Neisseria meningitidis and Neisseria gonorrhoeae.	Iron	70-74	transferrin	Homo sapiens	90-101
7927758-12	1994	These results indicate that (i) E. chaffeensis is sensitive to intracytoplasmic iron depletion, (ii) E. chaffeensis is sensitive to IFN-gamma-induced killing, and (iii) the anti-ehrlichial activity induced in human monocytes by IFN-gamma is mediated by limitation of available cytoplasmic iron and is not due to the generation of reactive oxygen intermediates or nitric oxide.	Iron	289-293	interferon gamma	Homo sapiens	132-141
7531047-1	1994	The production of red cells can be stimulated by pharmacologic doses of recombinant human erythropoietin (rHu-EPO), provided EPO-sensitive precursors and iron are available.	Iron	154-158	erythropoietin	Homo sapiens	90-104
7531047-9	1994	EPO has also been used as an adjuvant in autologous preoperative transfusion programs and has increased the available volume of red cells for transfusion particularly in conjunction with intravenous iron supplementation.	Iron	199-203	erythropoietin	Homo sapiens	0-3
7964124-6	1994	Iron uptake from transferrin was prevented by incubation at 4 degrees C and also by lysosomotrophic agents.	Iron	0-4	transferrin	Homo sapiens	17-28
7964124-1	1994	The mechanisms of iron uptake from transferrin and the effects of iron chelators on these processes were investigated in human neuroblastoma cells.	Iron	18-22	transferrin	Homo sapiens	35-46
7854652-1	1994	A pathway of iron transport not involving transferrin or transferrin receptors has been described as functioning in iron uptake into intestinal cells and in a hematopoietic cell line.	Iron	116-120	transferrin	Homo sapiens	57-68
7964124-9	1994	Iron uptake also occurred by a second process, which was not saturable up to a transferrin concentration of 0.06 mg/ml.	Iron	0-4	transferrin	Homo sapiens	79-90
7918403-0	1994	Extracellular ferrireductase activity of K562 cells is coupled to transferrin-independent iron transport.	Iron	90-94	transferrin	Homo sapiens	66-77
7948045-4	1994	Externally added catalase and desferrioxamine mesylate protected against the additional cytotoxicity of daunomycin in differentiated cells, pointing to hydrogen peroxide and iron ions as mediators of the toxic effect.	Iron	174-178	catalase	Homo sapiens	17-25
7954331-5	1994	The kaempferol induced lipid peroxidation was significantly stimulated by catalase and sodium azide in the presence of iron(III).	Iron	119-123	catalase	Rattus norvegicus	74-82
7918403-2	1994	Recently, a mechanism of iron transport in the absence of transferrin (Tf) was described for the human K562 cell line and a role for ferrireductase activity was implicated in this process as well [Inman, R. S., &amp; Wessling-Resnick, M. (1993) J. Biol.	Iron	25-29	transferrin	Homo sapiens	71-73
7918403-6	1994	The observation that membrane-impermeant ferricyanide competitively inhibits Tf-independent assimilation of iron from 55Fe-nitriloacetic acid indicates that this ferrireductase activity is indeed coupled to the transport mechanism.	Iron	108-112	transferrin	Homo sapiens	77-79
7918403-10	1994	Rather, the K562 cell ferrireductase appears to be tightly coupled to the mechanism of Tf-independent transport as demonstrated by its sensitivity to Cd2+, a specific inhibitor of non-Tf iron uptake by K562 cells.	Iron	187-191	transferrin	Homo sapiens	87-89
7918403-10	1994	Rather, the K562 cell ferrireductase appears to be tightly coupled to the mechanism of Tf-independent transport as demonstrated by its sensitivity to Cd2+, a specific inhibitor of non-Tf iron uptake by K562 cells.	Iron	187-191	transferrin	Homo sapiens	184-186
7847598-3	1994	Comparisons were made between anion-exchange separation of iron-saturated transferrin (Tf) by microcolumns (CDTect) and by the Fast Protein Liquid Chromatography (FPLC% and FPLC-MG), followed by double-antibody radioimmunoassay of collected fractions.	Iron	59-63	transferrin	Homo sapiens	74-85
7847598-3	1994	Comparisons were made between anion-exchange separation of iron-saturated transferrin (Tf) by microcolumns (CDTect) and by the Fast Protein Liquid Chromatography (FPLC% and FPLC-MG), followed by double-antibody radioimmunoassay of collected fractions.	Iron	59-63	transferrin	Homo sapiens	87-89
7866351-7	1994	For the meningococcal antigen TBP2, growth in iron-restricted laboratory media and a mouse model provide results which correlate well with those observed using convalescent human serum from individuals recovered from infections.	Iron	46-50	thioredoxin interacting protein	Mus musculus	30-34
8092098-0	1994	Assessment of iron status of Zairean women of childbearing age by serum transferrin receptor.	Iron	14-18	transferrin	Homo sapiens	72-83
7890311-0	1994	Lymphocyte lines under iron-depriving conditions: transferrin receptor expression related to various growth responses.	Iron	23-27	transferrin	Homo sapiens	50-61
7890311-1	1994	The relation of expression of cell surface transferrin receptors to growth responses under defined iron-depriving conditions was studied in mouse B-cell line PLV-01, human T-cell line Jurkat, and human B-cell line Raji.	Iron	99-103	transferrin	Homo sapiens	43-54
7890311-2	1994	Iron chelator deferoxamine at a concentration of 150 microM, which inhibited completely growth of the cell lines cultured in a serum-free transferrin-containing (5 micrograms/ml) medium, stimulated the surface transferrin receptor number to increase to 150-250% within a 24-h incubation period.	Iron	0-4	transferrin	Homo sapiens	138-149
7890311-2	1994	Iron chelator deferoxamine at a concentration of 150 microM, which inhibited completely growth of the cell lines cultured in a serum-free transferrin-containing (5 micrograms/ml) medium, stimulated the surface transferrin receptor number to increase to 150-250% within a 24-h incubation period.	Iron	0-4	transferrin	Homo sapiens	210-221
7890311-6	1994	The data show that, under limited availability of iron, a significant increase of transferrin receptor expression on lymphoid cells was found only when the growth of the cells was inhibited.	Iron	50-54	transferrin	Homo sapiens	82-93
7890311-7	1994	However, complete inhibition of growth achieved under different iron-depriving conditions is accompanied by different degrees of increase in transferrin receptor number.	Iron	64-68	transferrin	Homo sapiens	141-152
7928990-1	1994	The binding of iron-loaded human transferrin at the surface of Neisseria meningitidis is mediated by two polypeptides, Tbp1 and Tbp2.	Iron	15-19	transferrin	Homo sapiens	33-44
7994070-2	1994	The nurses of the Nashville Veterans" Administration Medical Center dialysis unit effectively combined these activities to improve the iron balance, hemoglobin, and hematocrit levels of chronic hemodialysis patients on erythropoietin.	Iron	135-139	erythropoietin	Homo sapiens	219-233
7929602-0	1994	Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: the effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake.	Iron	28-32	transferrin	Homo sapiens	45-56
7929602-2	1994	These data provide evidence for two saturable processes of Fe uptake from Tf, namely, specific receptor-mediated endocytosis and a second nonspecific, non-receptor-mediated mechanisms which saturated with respect to Fe uptake at a Tf concentration of approximately 0.3 mg/ml.	Iron	59-61	transferrin	Homo sapiens	74-76
7929602-2	1994	These data provide evidence for two saturable processes of Fe uptake from Tf, namely, specific receptor-mediated endocytosis and a second nonspecific, non-receptor-mediated mechanisms which saturated with respect to Fe uptake at a Tf concentration of approximately 0.3 mg/ml.	Iron	59-61	transferrin	Homo sapiens	231-233
7929602-6	1994	Membrane permeable chelators were equally effective at both Tf concentrations, whereas membrane impermeable chelators were significantly (P &lt; 0.001) more effective at reducing the internalisation of Fe at the higher Tf concentration, consistent with a mechanism of Fe uptake which occurred at a site in contact with the extracellular medium.	Iron	202-204	transferrin	Homo sapiens	219-221
7929602-8	1994	Three lysosomotrophic agents and the endocytosis inhibitor, phenylglyoxal, markedly reduced Fe uptake at both Tf concentrations, and it is concluded that a saturable process consistent with receptor-mediated endocytosis of Tf occurred at the lower Tf concentration, while the predominant mechanism of Fe uptake at high Tf concentrations was a second saturable process consistent with adsorptive pinocytosis.	Iron	92-94	transferrin	Homo sapiens	110-112
7929602-8	1994	Three lysosomotrophic agents and the endocytosis inhibitor, phenylglyoxal, markedly reduced Fe uptake at both Tf concentrations, and it is concluded that a saturable process consistent with receptor-mediated endocytosis of Tf occurred at the lower Tf concentration, while the predominant mechanism of Fe uptake at high Tf concentrations was a second saturable process consistent with adsorptive pinocytosis.	Iron	301-303	transferrin	Homo sapiens	223-225
7929602-8	1994	Three lysosomotrophic agents and the endocytosis inhibitor, phenylglyoxal, markedly reduced Fe uptake at both Tf concentrations, and it is concluded that a saturable process consistent with receptor-mediated endocytosis of Tf occurred at the lower Tf concentration, while the predominant mechanism of Fe uptake at high Tf concentrations was a second saturable process consistent with adsorptive pinocytosis.	Iron	301-303	transferrin	Homo sapiens	223-225
7929602-8	1994	Three lysosomotrophic agents and the endocytosis inhibitor, phenylglyoxal, markedly reduced Fe uptake at both Tf concentrations, and it is concluded that a saturable process consistent with receptor-mediated endocytosis of Tf occurred at the lower Tf concentration, while the predominant mechanism of Fe uptake at high Tf concentrations was a second saturable process consistent with adsorptive pinocytosis.	Iron	301-303	transferrin	Homo sapiens	223-225
7799139-7	1994	The uptake of HP-transferrin showed evidence of a receptor-mediated component in that it was partially inhibited by native protein and increased when transferrin receptors were upregulated by an iron chelator.	Iron	195-199	transferrin	Homo sapiens	17-28
7799139-7	1994	The uptake of HP-transferrin showed evidence of a receptor-mediated component in that it was partially inhibited by native protein and increased when transferrin receptors were upregulated by an iron chelator.	Iron	195-199	transferrin	Homo sapiens	150-161
7845533-2	1994	The iron transport protein transferrin is the major transport protein for aluminium, and aluminium gains access to cells by means of a specific cell surface transferrin receptor.	Iron	4-8	transferrin	Homo sapiens	27-38
7839567-7	1994	In contrast, macrophages from the 2 iron-loaded groups of mice produced more TNF-alpha (150% of control) without altering IL-1 alpha production.	Iron	36-40	tumor necrosis factor	Mus musculus	77-86
7945215-0	1994	The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity.	Iron	38-42	transferrin	Homo sapiens	14-25
7925932-0	1994	Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein.	Iron	0-4	transferrin	Homo sapiens	19-30
7925932-2	1994	We have investigated the conditions under which transferrin (the major iron-carrying protein in plasma) may release iron ions to catalyse the oxidation of LDL.	Iron	71-75	transferrin	Homo sapiens	48-59
7925932-2	1994	We have investigated the conditions under which transferrin (the major iron-carrying protein in plasma) may release iron ions to catalyse the oxidation of LDL.	Iron	116-120	transferrin	Homo sapiens	48-59
7925932-3	1994	Transferrin that had been incubated at pH 5.5 released approximately 10% of its bound iron in 24 h, as measured by ultrafiltration and atomic absorption spectroscopy.	Iron	86-90	transferrin	Homo sapiens	0-11
7925932-6	1994	The release of iron from transferrin in atherosclerotic lesions due to a localised acidic pH may help to explain why LDL oxidation occurs in these lesions.	Iron	15-19	transferrin	Homo sapiens	25-36
7945215-12	1994	The mammalian transferrin-independent iron transport system appears functionally similar to iron transport systems in both the bacterial and plant kingdoms which require the activities of both a surface reductase and a ferrous metal transporter.	Iron	38-42	transferrin	Homo sapiens	14-25
7945215-12	1994	The mammalian transferrin-independent iron transport system appears functionally similar to iron transport systems in both the bacterial and plant kingdoms which require the activities of both a surface reductase and a ferrous metal transporter.	Iron	92-96	transferrin	Homo sapiens	14-25
7945215-1	1994	Mammalian cells accumulate iron from ferric citrate or ferric nitrilotriacetate through the activity of a transferrin-independent iron transport system [Sturrock, Alexander, Lamb, Craven and Kaplan (1990) J. Biol.	Iron	27-31	transferrin	Homo sapiens	106-117
7945215-1	1994	Mammalian cells accumulate iron from ferric citrate or ferric nitrilotriacetate through the activity of a transferrin-independent iron transport system [Sturrock, Alexander, Lamb, Craven and Kaplan (1990) J. Biol.	Iron	130-134	transferrin	Homo sapiens	106-117
8073054-9	1994	AZn IL-1 beta-infused rats were characterized by high liver Fe, Zn, and metallothionein (MT) concentrations on Day 1; by Day 7, only MT concentrations remained elevated.	Iron	60-62	interleukin 1 beta	Rattus norvegicus	4-13
8093048-1	1994	Lactoferrin (LTF), which is the major iron-binding protein in milk and physiological fluids, belongs to the transferrin family.	Iron	38-42	serotransferrin	Bos taurus	108-119
8077204-10	1994	The results suggest that the C-terminal peptide of adrenodoxin, especially proline 108, affects the structural integrity of the iron-sulfur cluster and that electron donation from adrenodoxin to CYP11A1 and CYP11B1 is determined at least in part by different features of the cytochromes.	Iron	128-132	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	195-202
7803257-0	1994	The effect of iron overload and iron reductive treatment on the serum concentration of carbohydrate-deficient transferrin.	Iron	14-18	transferrin	Homo sapiens	110-121
7803257-0	1994	The effect of iron overload and iron reductive treatment on the serum concentration of carbohydrate-deficient transferrin.	Iron	32-36	transferrin	Homo sapiens	110-121
7860417-2	1994	Accumulated biological information led to a plausible model for the role of testicular transferrin in an iron shuttle system designed to transport ferric ions around the cellular tight junctions to the germ cells inside the blood-testis barrier.	Iron	105-109	transferrin	Homo sapiens	87-98
8073054-5	1994	In the AZn rats, IL-1 beta infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period.	Iron	139-143	interleukin 1 beta	Rattus norvegicus	17-26
8073054-5	1994	In the AZn rats, IL-1 beta infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period.	Iron	145-147	interleukin 1 beta	Rattus norvegicus	17-26
8077675-2	1994	Studies of macrophage iron acquisition have generally focused on iron uptake from transferrin via receptor-mediated endocytosis.	Iron	22-26	transferrin	Homo sapiens	82-93
8077675-2	1994	Studies of macrophage iron acquisition have generally focused on iron uptake from transferrin via receptor-mediated endocytosis.	Iron	65-69	transferrin	Homo sapiens	82-93
8063401-3	1994	Immunoblotting experiments using cell wall preparations from these staphylococci revealed the presence of the host iron-binding glycoprotein transferrin bound to S. aureus, S. epidermidis, S. capitis, S. haemolyticus, and S. hominis but not to S. warneri or S. saprophyticus.	Iron	115-119	transferrin	Homo sapiens	141-152
8063422-8	1994	Incubation of Fe2-transferrin and purified pyoverdin in concentrations similar to those found in the culture supernatant resulted in release iron from transferrin after 10 h at 37 degrees C. However, LasB significantly enhanced the rate constant for iron acquisition of pyoverdin from transferrin.	Iron	141-145	elastase LasB	Pseudomonas aeruginosa PAO1	200-204
8063422-8	1994	Incubation of Fe2-transferrin and purified pyoverdin in concentrations similar to those found in the culture supernatant resulted in release iron from transferrin after 10 h at 37 degrees C. However, LasB significantly enhanced the rate constant for iron acquisition of pyoverdin from transferrin.	Iron	250-254	elastase LasB	Pseudomonas aeruginosa PAO1	200-204
7520477-4	1994	Conversely, addition of the iron chelator desferrioxamine (100 microM) at the time of stimulation with IFN-gamma/LPS increases NOS activity up to 2.5-fold in J774 cells.	Iron	28-32	interferon gamma	Mus musculus	103-112
7520477-4	1994	Conversely, addition of the iron chelator desferrioxamine (100 microM) at the time of stimulation with IFN-gamma/LPS increases NOS activity up to 2.5-fold in J774 cells.	Iron	28-32	toll-like receptor 4	Mus musculus	113-116
8083587-6	1994	Iron delocalization occurred during ischemia, as indicated by a significant rise in percent saturation of transferrin over that of the corresponding sham group (35% +/- 2% vs 25% +/- 2%; p &lt; 0.05) and persisted during reperfusion (39% +/- 5% vs 27% +/- 3%; p &lt; 0.05).	Iron	0-4	transferrin	Rattus norvegicus	106-117
7815950-7	1994	Based on alignment with XDH it is inferred that the smallest subunit (NDHB) carries an iron-sulphur cluster, that the middle-sized subunit (NDHA) binds FAD, and that the largest NDH subunit (NDHC) corresponds to the molybdopterin-binding domain of XDH.	Iron	87-91	xdh	Paenarthrobacter nicotinovorans	24-27
7808929-0	1994	[Effect of human recombinant erythropoietin (r-EPO) on behavior of iron status parameters in patients with chronic renal failure treated with dialysis].	Iron	67-71	erythropoietin	Homo sapiens	29-43
7808929-0	1994	[Effect of human recombinant erythropoietin (r-EPO) on behavior of iron status parameters in patients with chronic renal failure treated with dialysis].	Iron	67-71	erythropoietin	Homo sapiens	47-50
7808929-1	1994	For proper erythropoietic response to r-Epo iron, folic acid and B12 vitamin are needed.	Iron	44-48	erythropoietin	Homo sapiens	40-43
7899791-2	1994	Iron status was assessed using serum transferrin, serum iron, transferrin saturation and haemoglobin.	Iron	0-4	transferrin	Homo sapiens	37-48
8063820-7	1994	We demonstrate here that the [35S]methionine-labeled immunoaffinity-purified estrogen-inducible membrane glycoprotein binds to the transferrin affinity columns similar to iron-modulated transferrin receptors.	Iron	171-175	transferrin	Homo sapiens	186-197
7975362-4	1994	Iron excretion after L 1 treatment was approximately 65% of that obtained with Desferal.	Iron	0-4	immunoglobulin kappa variable 1-16	Homo sapiens	21-24
7975362-8	1994	An incomplete absorption from gut and some reutilization of chelated iron may be responsible for less potent iron chelation by L 1 in comparison to Desferal.	Iron	69-73	immunoglobulin kappa variable 1-16	Homo sapiens	127-130
7975362-8	1994	An incomplete absorption from gut and some reutilization of chelated iron may be responsible for less potent iron chelation by L 1 in comparison to Desferal.	Iron	109-113	immunoglobulin kappa variable 1-16	Homo sapiens	127-130
7975366-5	1994	Hydroxypyridones, especially 1,2-dimethyl-3-hydroxypyrid-4-one (L 1-Deferiprone), are the most intensively studied oral iron chelators.	Iron	120-124	immunoglobulin kappa variable 1-16	Homo sapiens	64-67
7975366-6	1994	In animal and clinical studies L 1 administration caused iron excretion comparable to that obtained by desferrioxamine, however, some serious adverse effects (including agranulocytosis) related to L 1 treatment were observed.	Iron	57-61	immunoglobulin kappa variable 1-16	Homo sapiens	31-34
8074667-7	1994	Iron depletion is however completely reversed 24 h later when maximal TRF-R upregulation occurs in IFN alpha-treated cells.	Iron	0-4	interferon alpha 1	Homo sapiens	99-108
8074667-8	1994	We suggest that IFN alpha-induced iron depletion elicits a homeostatic cellular response through upregulation of TRF-R.	Iron	34-38	interferon alpha 1	Homo sapiens	16-25
7519607-0	1994	L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.	Iron	49-53	calmodulin 1	Homo sapiens	15-25
8052309-0	1994	An efficient mimic of cytochrome P-450 from a zeolite-encaged iron complex in a polymer membrane.	Iron	62-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-38
8068004-9	1994	We examined whether the inhibition of Ca2+ influx was due to an interaction of the inhibitor imidazole nitrogen with the haem iron of the putative cytochrome P-450 by comparing the activity of two compounds, identical except that one was methylated at the imidazole 2-position.	Iron	126-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	147-163
7519607-0	1994	L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.	Iron	49-53	nitric oxide synthase 2	Homo sapiens	77-98
7519607-8	1994	We have examined how L-arginine and calmodulin control the ligand binding and electron acceptor properties of the NOS heme iron.	Iron	123-127	calmodulin 1	Homo sapiens	36-46
7519607-13	1994	Anaerobic titration of a calmodulin-bound, L-arginine-free NOS with NADPH led to incomplete reduction of the heme iron; full reduction was achieved only in the presence of added L-arginine.	Iron	114-118	calmodulin 1	Homo sapiens	25-35
7519607-15	1994	In contrast, bound calmodulin does not alter the NOS affinity for L-arginine or heme ligands and may function solely as a switch that enables electrons to pass from the flavin domain onto the heme iron.	Iron	197-201	calmodulin 1	Homo sapiens	19-29
7944532-5	1994	The most prominent finding was that growth hormone responses to glucagon stimulation were significantly impaired in all of the patients with iron overload.	Iron	141-145	growth hormone 1	Homo sapiens	36-50
7952112-0	1994	Reversed-phase high-performance liquid chromatography of non-transferrin-bound iron and some hydroxypyridone and hydroxypyrone chelators.	Iron	79-83	transferrin	Homo sapiens	61-72
7952112-7	1994	The direct determination of non-transferrin-bound Fe at micromolar concentrations in serum is possible with this approach.	Iron	50-52	transferrin	Homo sapiens	32-43
7522839-4	1994	All patients undergoing open heart surgery appear to release iron to plasma transferrin, increasing its iron saturation.	Iron	61-65	transferrin	Homo sapiens	76-87
7522839-4	1994	All patients undergoing open heart surgery appear to release iron to plasma transferrin, increasing its iron saturation.	Iron	104-108	transferrin	Homo sapiens	76-87
7522839-6	1994	Saturation of transferrin with iron eliminates its iron-binding antioxidant properties, which can result in a stimulation of iron-dependent radical damage to selected detector molecules.	Iron	31-35	transferrin	Homo sapiens	14-25
7522839-6	1994	Saturation of transferrin with iron eliminates its iron-binding antioxidant properties, which can result in a stimulation of iron-dependent radical damage to selected detector molecules.	Iron	51-55	transferrin	Homo sapiens	14-25
7522839-6	1994	Saturation of transferrin with iron eliminates its iron-binding antioxidant properties, which can result in a stimulation of iron-dependent radical damage to selected detector molecules.	Iron	51-55	transferrin	Homo sapiens	14-25
8051491-8	1994	ARDS patients had transferrin levels that were significantly lower (1.76 +/- 0.13 gm/L) than those of normal controls (2.91 +/- 0.12 gm/L, p &lt; 0.001), which decreased the ability of their plasma to protect phospholipid membranes and DNA against iron-stimulated free radical damage.	Iron	248-252	transferrin	Homo sapiens	18-29
7863732-0	1994	Blood serum transferrin concentration in cattle in various physiological states, in veal calves fed different amounts of iron, and in cattle affected by infectious and non-infectious diseases.	Iron	121-125	serotransferrin	Bos taurus	12-23
8035195-3	1994	In this study the spatial and temporal pattern of iron and its regulatory proteins transferrin and ferritin are quantitatively examined in the rat CNS during the first 3 weeks of postnatal life and in adults and aged animals.	Iron	50-54	transferrin	Rattus norvegicus	83-94
8040772-0	1994	Increases in hemoglobin concentration and iron needs in response to growth hormone treatment.	Iron	42-46	growth hormone 1	Homo sapiens	68-82
8040772-4	1994	The prevalence of iron deficiency increased  from 6 patients (17%) with initial deficiency to 20 (56%) patients after therapy, indicating that iron supplementation should be considered in children treated with recombinant human growth hormone.	Iron	18-22	growth hormone 1	Homo sapiens	228-242
7933664-6	1994	Furthermore, serum Epo correlated with the serum iron concentration, but not with the other parameters, such as reticulocytes, serum protein and proteinuria.	Iron	49-53	erythropoietin	Homo sapiens	19-22
7994996-6	1994	Meanwhile, the protein and IgG levels and activated CD4-cells were increased in the cerebrospinal fluid, indicating the involvement of chronic inflammation in the iron deposits in this case.	Iron	163-167	CD4 molecule	Homo sapiens	52-55
7953673-0	1994	The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis.	Iron	4-8	lactotransferrin	Homo sapiens	25-41
8041736-4	1994	We tested the hypothesis that this catalytic function is fostered by iron released from the heme moiety of cytochrome P-450.	Iron	69-73	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	107-123
8041736-11	1994	In summary, several chemically distinct cytochrome P-450 inhibitors reduced iron release, and thereby, hydroxyl radical formation and reoxygenation-induced lethal cell injury, without inhibiting superoxide radical formation.	Iron	76-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	40-56
8055929-0	1994	The mechanism of iron release from transferrin.	Iron	17-21	transferrin	Homo sapiens	35-46
8055929-2	1994	The role of protonation of amino acid ligands involved in iron release from human serum transferrin, previously saturated with nitrilotriacetatoiron(III) complex, has been elucidated in acidic media.	Iron	58-62	transferrin	Homo sapiens	88-99
7953673-1	1994	Lactotransferrin is a glycoprotein that specifically binds and transports iron.	Iron	74-78	lactotransferrin	Homo sapiens	0-16
8043985-6	1994	Sufficient evidence is available to justify construction of long-term prospective studies in humans in which would be monitored (i) levels of iron and phytate intake, (ii) serum transferrin iron saturation and ferritin, (iii) fecal levels of iron and hydroxyl radicals, and (iv) appearance of colorectal polyps, adenomas and carcinomas.	Iron	190-194	transferrin	Homo sapiens	178-189
8041631-0	1994	Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5" leader sequences distinct from the iron responsive element.	Iron	118-122	interleukin 1 beta	Homo sapiens	48-66
8061659-2	1994	Human iron-free transferrin and human serum albumin were treated with [11C]cyanogen bromide of high specific radioactivity under physiological conditions to give the labelled proteins in high radiochemical yields using a simple and rapid procedure.	Iron	6-10	transferrin	Homo sapiens	16-27
8031836-3	1994	Each of these spectra demonstrate that the iron of heme bound by hemopexin is paramagnetic and low-spin.	Iron	43-47	hemopexin	Oryctolagus cuniculus	65-74
8048526-0	1994	Biliary excretion of plasma non-transferrin-bound iron in rats: pathogenetic importance in iron-overload disorders.	Iron	50-54	transferrin	Rattus norvegicus	32-43
8048526-1	1994	Plasma non-transferrin-bound iron (NTB-iron) is a potentially toxic form of iron, which is efficiently taken up by the normal, as well as the chronically iron-overloaded liver.	Iron	29-33	transferrin	Rattus norvegicus	11-22
8048526-1	1994	Plasma non-transferrin-bound iron (NTB-iron) is a potentially toxic form of iron, which is efficiently taken up by the normal, as well as the chronically iron-overloaded liver.	Iron	39-43	transferrin	Rattus norvegicus	11-22
8048526-1	1994	Plasma non-transferrin-bound iron (NTB-iron) is a potentially toxic form of iron, which is efficiently taken up by the normal, as well as the chronically iron-overloaded liver.	Iron	39-43	transferrin	Rattus norvegicus	11-22
8048526-1	1994	Plasma non-transferrin-bound iron (NTB-iron) is a potentially toxic form of iron, which is efficiently taken up by the normal, as well as the chronically iron-overloaded liver.	Iron	39-43	transferrin	Rattus norvegicus	11-22
7919266-0	1994	[Change in level and saturation by iron of blood plasma transferrin in hereditary retinal degeneration in rats].	Iron	35-39	transferrin	Rattus norvegicus	56-67
8043985-6	1994	Sufficient evidence is available to justify construction of long-term prospective studies in humans in which would be monitored (i) levels of iron and phytate intake, (ii) serum transferrin iron saturation and ferritin, (iii) fecal levels of iron and hydroxyl radicals, and (iv) appearance of colorectal polyps, adenomas and carcinomas.	Iron	190-194	transferrin	Homo sapiens	178-189
7883057-0	1994	Inhibition of in vitro replication of the oyster parasite Perkinsus marinus by the natural iron chelators transferrin, lactoferrin, and desferrioxamine.	Iron	91-95	transferrin	Homo sapiens	106-117
7912169-1	1994	The effects of a xanthine oxidase-mediated free radical-generating system containing purine and iron-loaded transferrin or solutions containing hydrogen peroxide and iron-loaded transferrin on substrate utilization and high-energy phosphates were evaluated by nuclear magnetic resonance (NMR) spectroscopy in isolated perfused rat hearts.	Iron	166-170	transferrin	Rattus norvegicus	178-189
7883057-1	1994	The mammalian iron-binding proteins transferrin and lactoferrin, the bactericidal peptide lactoferricin B, and the bacterial siderophore desferrioxamine were tested for their ability to inhibit the in vitro replication of the oyster parasite Perkinsus marinus.	Iron	14-18	transferrin	Homo sapiens	36-47
7997450-1	1994	Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development.	Iron	153-157	transferrin	Rattus norvegicus	25-36
7841356-1	1994	In vitro monocyte-derived tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production was assessed in iron deficient with anemia (IDA), iron deficient without anemia (ID) and control infants.	Iron	129-133	tumor necrosis factor	Homo sapiens	56-65
7841356-1	1994	In vitro monocyte-derived tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production was assessed in iron deficient with anemia (IDA), iron deficient without anemia (ID) and control infants.	Iron	129-133	interleukin 1 beta	Homo sapiens	71-89
7841356-1	1994	In vitro monocyte-derived tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production was assessed in iron deficient with anemia (IDA), iron deficient without anemia (ID) and control infants.	Iron	129-133	interleukin 1 beta	Homo sapiens	91-100
7841356-5	1994	After iron therapy, the LPS stimulated TNF-alpha secretion by cells of IDA infants returned to the levels observed in the other groups.	Iron	6-10	tumor necrosis factor	Homo sapiens	39-48
7841356-6	1994	Since TNF-alpha plays a key role in iron metabolism, we speculate that increased TNF production in IDA infants could exacerbate the inhibition of erythroid proliferation present in these conditions.	Iron	36-40	tumor necrosis factor	Homo sapiens	6-15
7841356-6	1994	Since TNF-alpha plays a key role in iron metabolism, we speculate that increased TNF production in IDA infants could exacerbate the inhibition of erythroid proliferation present in these conditions.	Iron	36-40	tumor necrosis factor	Homo sapiens	6-9
7959592-6	1994	The addition of excess iron (as 100 micrograms/ml holo transferrin) caused reduction of the level of TfR mRNA, however, the iron chelator defferoxamine caused its increase.	Iron	23-27	transferrin	Homo sapiens	55-66
8021761-0	1994	Effect of iron overload on the response to recombinant interferon-alfa treatment in transfusion-dependent patients with thalassemia major and chronic hepatitis C. The purpose of this study was to determine whether interferon-alfa (IFN-alpha) therapy benefits patients with transfusion-dependent thalassemia and chronic active hepatitis C, and whether their iron burden modifies the response to this therapy.	Iron	10-14	interferon alpha 1	Homo sapiens	214-240
8021761-3	1994	The response to IFN-alpha therapy was inversely related (p &lt; 0.002) to the liver iron burden as assessed by atomic absorption, the histologic semiquantitative method, or both methods.	Iron	84-88	interferon alpha 1	Homo sapiens	16-25
8021761-5	1994	We conclude that IFN-alpha represents a useful therapeutic option for children with transfusion-dependent thalassemia and chronic active hepatitis C with a mild to moderate iron burden.	Iron	173-177	interferon alpha 1	Homo sapiens	17-26
7997450-1	1994	Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development.	Iron	153-157	transferrin	Rattus norvegicus	38-40
8018702-0	1994	Regulation of iron uptake and transport by transferrin in Caco-2 cells, an intestinal cell line.	Iron	14-18	transferrin	Homo sapiens	43-54
7520607-3	1994	METHODS: Evidence of iron overload was established by measuring the percentage saturation of plasma transferrin.	Iron	21-25	transferrin	Homo sapiens	100-111
8016074-6	1994	It is known that His-504 in soybean lipoxygenase 1, which corresponds to His-532 in lipoxygenase 2, is one of the iron-binding ligands essential for lipoxygenase activity.	Iron	114-118	seed linoleate 13S-lipoxygenase-1	Glycine max	36-50
8188178-1	1994	To explore a mechanism of interleukin (IL)-6-induced hypoferremia in rats, iron metabolism was investigated both in vivo and in vitro.	Iron	75-79	interleukin 6	Rattus norvegicus	26-44
8205543-7	1994	The addition of IFN-alpha to this concentration of gallium significantly increased the gallium-induced block of iron uptake, resulting in an increase in transferrin receptors and an inhibition of cell growth.	Iron	112-116	interferon alpha 1	Homo sapiens	16-25
8205543-7	1994	The addition of IFN-alpha to this concentration of gallium significantly increased the gallium-induced block of iron uptake, resulting in an increase in transferrin receptors and an inhibition of cell growth.	Iron	112-116	transferrin	Homo sapiens	153-164
8205543-9	1994	Our studies suggest that gallium and IFN-alpha synergistically inhibit DNA synthesis through a mechanism that includes inhibition of cellular iron uptake and depletion of intracellular iron below the critical level needed to maintain DNA synthesis.	Iron	142-146	interferon alpha 1	Homo sapiens	37-46
8205543-9	1994	Our studies suggest that gallium and IFN-alpha synergistically inhibit DNA synthesis through a mechanism that includes inhibition of cellular iron uptake and depletion of intracellular iron below the critical level needed to maintain DNA synthesis.	Iron	185-189	interferon alpha 1	Homo sapiens	37-46
8206903-0	1994	Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron.	Iron	32-36	transferrin	Homo sapiens	14-25
8206903-0	1994	Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron.	Iron	112-116	transferrin	Homo sapiens	14-25
8206903-1	1994	Non-transferrin-bound iron (NTBI) uptake occurs in a variety of cells by a saturable, specific and temperature-sensitive process.	Iron	22-26	transferrin	Homo sapiens	4-15
8203918-2	1994	IRE-BP binds to stem-loop structures, iron-responsive elements (IREs), which are located in the untranslated regions of the mRNAs for several genes including ferritin, and the transferrin receptor.	Iron	38-42	transferrin	Homo sapiens	176-187
8205708-5	1994	Transferrin saturation (TS), calculated as (serum iron/total iron-binding capacity) x 100, was categorized as low (&lt; or = 10%), normal (11% to 61%), or elevated (&gt; or = 62%).	Iron	61-65	transferrin	Homo sapiens	0-11
8188178-2	1994	Recombinant IL-6 was intraperitoneally administered to male Wistar rats and the serial change of parameters related to iron metabolism was examined.	Iron	119-123	interleukin 6	Rattus norvegicus	12-16
8188178-8	1994	By ferrokinetic study with plasma that contained iron 59-labeled transferrin, the plasma iron disappearance half time, calculated from the disappearance curve, was significantly shortened from 55 min to 22 min by IL-6 treatment (p &lt; 0.01).	Iron	49-53	transferrin	Rattus norvegicus	65-76
8188178-8	1994	By ferrokinetic study with plasma that contained iron 59-labeled transferrin, the plasma iron disappearance half time, calculated from the disappearance curve, was significantly shortened from 55 min to 22 min by IL-6 treatment (p &lt; 0.01).	Iron	49-53	interleukin 6	Rattus norvegicus	213-217
8188178-8	1994	By ferrokinetic study with plasma that contained iron 59-labeled transferrin, the plasma iron disappearance half time, calculated from the disappearance curve, was significantly shortened from 55 min to 22 min by IL-6 treatment (p &lt; 0.01).	Iron	89-93	transferrin	Rattus norvegicus	65-76
8188178-8	1994	By ferrokinetic study with plasma that contained iron 59-labeled transferrin, the plasma iron disappearance half time, calculated from the disappearance curve, was significantly shortened from 55 min to 22 min by IL-6 treatment (p &lt; 0.01).	Iron	89-93	interleukin 6	Rattus norvegicus	213-217
7973806-2	1994	In recent years, it has been reported that the transferrin can play an important role in the local regulation of ovarian function, apart from its iron-binding characteristic.	Iron	146-150	transferrin	Homo sapiens	47-58
7514870-6	1994	Ferrous iron and the reducing agents cysteine and thiosulphate accelerate the rate of recovery of insulin secretion, and ferrous iron and thiosulphate stimulate the recovery of islet aconitase activity, suggesting that iron-sulphurcentre reconstitution may be involved in the recovery process.	Iron	0-12	insulin	Homo sapiens	98-105
8200334-0	1994	The process of cellular uptake of iron from transferrin.	Iron	34-38	transferrin	Rattus norvegicus	44-55
8200334-2	1994	In an attempt to improve our understanding of the complex interplay between cell compartments and chemical species during cellular uptake of iron from transferrin, we designed a computer simulation program based on current models of receptor-mediated endocytosis and pinocytosis.	Iron	141-145	transferrin	Rattus norvegicus	151-162
8200334-3	1994	The program calculates and visualizes, as a function of time, the changes in transferrin, apotransferrin, and iron concentrations occurring in all relevant cellular compartments during cellular iron acquisition from transferrin.	Iron	194-198	transferrin	Rattus norvegicus	77-88
8200334-3	1994	The program calculates and visualizes, as a function of time, the changes in transferrin, apotransferrin, and iron concentrations occurring in all relevant cellular compartments during cellular iron acquisition from transferrin.	Iron	194-198	transferrin	Rattus norvegicus	93-104
8073646-3	1994	Administration of 105 mg elemental iron per day (1 tablet of Ferronat retard, Spofa) for a period of 6 months led in 17 patients (71%) to a statistically significant increase of erythrocytes, serum ferritin, the iron plasma level and transferrin saturation.	Iron	35-39	transferrin	Homo sapiens	234-245
8073646-8	1994	Substitution treatment with iron preparations extends the opportunities to treat anaemia during regular dialyzation treatment and is at the same time also very important from the economical aspect as it makes more expedient selection of patients suited for recombinant erythropoietin treatment possible.	Iron	28-32	erythropoietin	Homo sapiens	269-283
8204100-1	1994	The uptake of iron by the liver and cerebellum was measured in rats using [59Fe]transferrin.	Iron	14-18	transferrin	Rattus norvegicus	80-91
8185313-1	1994	Rabbit red blood cell hexokinase (EC 2.7.1.1) has been shown to be inactivated in vitro by incubating intact erythrocytes in the presence of an oxygen-radical-generating system represented by ascorbate and iron.	Iron	206-210	hexokinase-2	Oryctolagus cuniculus	22-32
7514870-6	1994	Ferrous iron and the reducing agents cysteine and thiosulphate accelerate the rate of recovery of insulin secretion, and ferrous iron and thiosulphate stimulate the recovery of islet aconitase activity, suggesting that iron-sulphurcentre reconstitution may be involved in the recovery process.	Iron	8-12	insulin	Homo sapiens	98-105
7514870-11	1994	These results show that IL-1 beta-induced islet dysfunction is reversed by the inhibition of NO synthase, that recovery of insulin secretion is stimulated by iron and reducing agents, and that the recovery process appears to require mRNA transcription.	Iron	158-162	interleukin 1 beta	Homo sapiens	24-33
7514870-11	1994	These results show that IL-1 beta-induced islet dysfunction is reversed by the inhibition of NO synthase, that recovery of insulin secretion is stimulated by iron and reducing agents, and that the recovery process appears to require mRNA transcription.	Iron	158-162	insulin	Homo sapiens	123-130
7961596-0	1994	Reduction site of transferrin-dependent and transferrin-independent iron in cultured human fibroblasts.	Iron	68-72	transferrin	Homo sapiens	18-29
8192672-0	1994	Interaction of transferrin and its iron-binding fragments with heparin.	Iron	35-39	serotransferrin	Bos taurus	15-26
8192672-1	1994	The interaction of heparin with transferrin (Tf; bovine and rat) and the isolated iron-binding lobes of bovine Tf were investigated.	Iron	82-86	serotransferrin	Bos taurus	111-113
8192672-3	1994	Both the iron-free and iron-saturated forms of Tf were strongly bound by the column at pH 5.6, but only the iron-free form revealed significant affinity at pH 7.4.	Iron	9-13	serotransferrin	Bos taurus	47-49
8192672-3	1994	Both the iron-free and iron-saturated forms of Tf were strongly bound by the column at pH 5.6, but only the iron-free form revealed significant affinity at pH 7.4.	Iron	23-27	serotransferrin	Bos taurus	47-49
8192672-3	1994	Both the iron-free and iron-saturated forms of Tf were strongly bound by the column at pH 5.6, but only the iron-free form revealed significant affinity at pH 7.4.	Iron	23-27	serotransferrin	Bos taurus	47-49
8192672-5	1994	In the presence of heparin, iron release from the N-terminal lobe of native bovine Tf was accelerated and from the C-terminal lobe it was slightly reduced.	Iron	28-32	serotransferrin	Bos taurus	83-85
8192672-8	1994	It is concluded that the consequences for iron-binding strength of the two transferrin lobes are diagonally opposite when Tf is bound to heparin as opposed to its natural cell-surface receptor.	Iron	42-46	serotransferrin	Bos taurus	75-86
8192672-8	1994	It is concluded that the consequences for iron-binding strength of the two transferrin lobes are diagonally opposite when Tf is bound to heparin as opposed to its natural cell-surface receptor.	Iron	42-46	serotransferrin	Bos taurus	122-124
8020628-5	1994	A significant positive correlation between CD4/CD8 ratios and the amount of iron mobilised by phlebotomy was found during this study.	Iron	76-80	CD4 molecule	Homo sapiens	43-46
8020628-6	1994	A novel correlation between the relative proportions of CD4+ and CD8+ cells and iron overload is confirmed by the follow-up of iron re-entry in the serum transferrin pool in the treated patients.	Iron	80-84	CD4 molecule	Homo sapiens	56-59
8020628-6	1994	A novel correlation between the relative proportions of CD4+ and CD8+ cells and iron overload is confirmed by the follow-up of iron re-entry in the serum transferrin pool in the treated patients.	Iron	127-131	CD4 molecule	Homo sapiens	56-59
7961596-0	1994	Reduction site of transferrin-dependent and transferrin-independent iron in cultured human fibroblasts.	Iron	68-72	transferrin	Homo sapiens	44-55
7961596-1	1994	Mammalian cells internalize iron as diferric transferrin (Fe2Tf) iron via receptor-mediated endocytosis (RME) and a redox mechanism under physiological condition and as an iron salt through the Tf-independent iron uptake (Tf-IU) system under morbid conditions.	Iron	28-32	transferrin	Homo sapiens	45-56
7961596-1	1994	Mammalian cells internalize iron as diferric transferrin (Fe2Tf) iron via receptor-mediated endocytosis (RME) and a redox mechanism under physiological condition and as an iron salt through the Tf-independent iron uptake (Tf-IU) system under morbid conditions.	Iron	65-69	transferrin	Homo sapiens	45-56
7961596-1	1994	Mammalian cells internalize iron as diferric transferrin (Fe2Tf) iron via receptor-mediated endocytosis (RME) and a redox mechanism under physiological condition and as an iron salt through the Tf-independent iron uptake (Tf-IU) system under morbid conditions.	Iron	65-69	transferrin	Homo sapiens	45-56
8164662-5	1994	FRE2 expression, like FRE1 expression, is induced by iron deprivation, and at least part of this control takes place at the transcriptional level, since 156 nucleotides upstream of the initiator AUG conferred iron-dependent regulation when fused to a heterologous gene.	Iron	53-57	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	22-26
8025673-3	1994	During iron-limited growth mRNA levels for Tpi1p and Tdh3p were at least 3-fold lower than during iron-saturated growth; as shown with a hem1 mutant strain this regulation does not require haem synthesis.	Iron	7-11	triose-phosphate isomerase TPI1	Saccharomyces cerevisiae S288C	43-48
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	61-65	triose-phosphate isomerase TPI1	Saccharomyces cerevisiae S288C	19-23
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	103-107	triose-phosphate isomerase TPI1	Saccharomyces cerevisiae S288C	19-23
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	103-107	triose-phosphate isomerase TPI1	Saccharomyces cerevisiae S288C	19-23
8075594-8	1994	Supporting too much iron as a free radical-generating culprit in the risk of cancer, NHANES I data indicated that high body iron stores, manifested by increased transferrin saturation, are associated with an increased cancer risk.	Iron	124-128	transferrin	Homo sapiens	161-172
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	103-107	triose-phosphate isomerase TPI1	Saccharomyces cerevisiae S288C	19-23
8047480-0	1994	Low iron levels may stunt epoetin alfa response.	Iron	4-8	erythropoietin	Homo sapiens	26-33
8178799-1	1994	The present investigation evaluated the serum transferrin receptor concentration in subjects with nontransfusional iron overload who were identified in two separate studies on the basis of a serum ferritin level above 400 micrograms/L.	Iron	115-119	transferrin	Homo sapiens	46-57
7993405-5	1994	Transferrin saturation (serum iron concentration divided by total iron-binding capacity) was used as a measure of the amount of circulating iron available to tissues.	Iron	30-34	transferrin	Homo sapiens	0-11
7909515-2	1994	When a human plasma-cytoma cell line (ARH-77) is treated with an iron source (hemin), the TfR mRNA is destabilized and a shorter TfR RNA appears.	Iron	65-69	low density lipoprotein receptor adaptor protein 1	Homo sapiens	38-41
8148611-1	1994	The stereochemistry of the Fe(III) binding sites in chicken egg phosvitin (PST) at very high iron content, in solution and as a powder, has been investigated through EXAFS spectroscopy.	Iron	93-97	Casein kinase II subunit beta	Gallus gallus	64-73
8131214-2	1994	In the present work, iron (FeC6H5O7) and zinc (ZnCl2) were tested in comparison to nickel (NiCl2) and cobalt (CoCl2) for their effect on six different surface molecules known to be involved in recognition and activation processes, namely CD4, CD2, CD3, CD8, HLA-ABC, and HLA-DR. Iron was seen to down-modulate expression of the CD4 and the CD2 molecules on the surface of T-lymphocytes, as indicated by a decrease in the mean fluorescence intensity measured by FACS analysis.	Iron	21-25	CD4 molecule	Homo sapiens	238-241
8131214-2	1994	In the present work, iron (FeC6H5O7) and zinc (ZnCl2) were tested in comparison to nickel (NiCl2) and cobalt (CoCl2) for their effect on six different surface molecules known to be involved in recognition and activation processes, namely CD4, CD2, CD3, CD8, HLA-ABC, and HLA-DR. Iron was seen to down-modulate expression of the CD4 and the CD2 molecules on the surface of T-lymphocytes, as indicated by a decrease in the mean fluorescence intensity measured by FACS analysis.	Iron	21-25	CD4 molecule	Homo sapiens	328-331
8131214-4	1994	In addition, the iron-mediated CD4 down-modulation reached its lowest level by 12 hr, at which time a striking decrease in the percentage of CD4+, but not CD8+, cells was observed.	Iron	17-21	CD4 molecule	Homo sapiens	31-34
8131214-4	1994	In addition, the iron-mediated CD4 down-modulation reached its lowest level by 12 hr, at which time a striking decrease in the percentage of CD4+, but not CD8+, cells was observed.	Iron	17-21	CD4 molecule	Homo sapiens	141-144
8151672-0	1994	The effect of iron on the invasiveness of Escherichia coli carrying the inv gene of Yersinia pseudotuberculosis.	Iron	14-18	putative invertase	Escherichia coli	26-29
8027374-0	1994	Non-transferrin bound iron and neutropenia after cytotoxic chemotherapy.	Iron	22-26	transferrin	Homo sapiens	4-15
8027374-1	1994	AIMS: To investigate and characterise the appearance of non-transferrin bound iron (NTBI) in the serum of patients after cytotoxic chemotherapy and to compare this with the onset and duration of neutropenia.	Iron	78-82	transferrin	Homo sapiens	60-71
8027374-2	1994	METHOD: Non-transferrin bound iron was measured by a bleomycin assay in patients undergoing intensive chemotherapy for treatment of acute leukaemia or lymphoma.	Iron	30-34	transferrin	Homo sapiens	12-23
8163646-3	1994	The effect of deferoxamine was reversed by iron-saturated transferrin (holotransferrin) but not by iron-free transferrin (apotransferrin).	Iron	43-47	transferrin	Homo sapiens	58-69
8163646-3	1994	The effect of deferoxamine was reversed by iron-saturated transferrin (holotransferrin) but not by iron-free transferrin (apotransferrin).	Iron	43-47	transferrin	Homo sapiens	75-86
8163646-4	1994	Chloroquine, which prevents release of iron from transferrin by raising endocytic and lysosomal pH, induced human Mphi to kill Hc.	Iron	39-43	transferrin	Homo sapiens	49-60
8144581-4	1994	The interaction of 125I-LF-L and 125I-LF with RAGE was independent of iron in LF and was competed by addition of an excess of unlabeled carboxyl-terminal portion of LF.	Iron	70-74	advanced glycosylation end product-specific receptor	Mus musculus	46-50
8125927-2	1994	A transferrin-independent iron transport system in cells containing transferrin receptors was described previously by several investigators.	Iron	26-30	transferrin	Homo sapiens	2-13
8202725-6	1994	Iron is an essential element for hemoglobin synthesis and its importance has been emphasized in individuals receiving recombinant human erythropoietin (rHuEPO).	Iron	0-4	erythropoietin	Homo sapiens	136-150
8202725-8	1994	In addition, higher doses of rHuEPO create a state of functional (or relative) iron deficiency that is characterized by a low percent transferrin saturation in the face of adequate iron stores.	Iron	79-83	transferrin	Homo sapiens	134-145
8120921-14	1994	CONCLUSION: The apparent dose-response for serum ferritin level and adenoma risk suggest that exposure to iron may be related to adenoma formation.	Iron	106-110	ferritin-1, chloroplastic	Nicotiana tabacum	49-57
7511531-1	1994	It has recently been proposed that cellular iron homeostasis in mammalian cells is regulated at the post-transcriptional level by the reciprocal control of transferrin receptor and ferritin mRNA expression via an iron-regulatory factor.	Iron	44-48	transferrin	Homo sapiens	156-167
7511531-3	1994	In the present study, we show that in vivo the affinity of iron-regulatory factor for iron-responsive elements in liver reflects the long-term iron status of the tissue in animal models for iron overloading and iron deficiency, when combined with altered transferrin saturation and serum iron levels.	Iron	59-63	transferrin	Homo sapiens	255-266
7511531-3	1994	In the present study, we show that in vivo the affinity of iron-regulatory factor for iron-responsive elements in liver reflects the long-term iron status of the tissue in animal models for iron overloading and iron deficiency, when combined with altered transferrin saturation and serum iron levels.	Iron	86-90	transferrin	Homo sapiens	255-266
7511531-3	1994	In the present study, we show that in vivo the affinity of iron-regulatory factor for iron-responsive elements in liver reflects the long-term iron status of the tissue in animal models for iron overloading and iron deficiency, when combined with altered transferrin saturation and serum iron levels.	Iron	86-90	transferrin	Homo sapiens	255-266
7511531-3	1994	In the present study, we show that in vivo the affinity of iron-regulatory factor for iron-responsive elements in liver reflects the long-term iron status of the tissue in animal models for iron overloading and iron deficiency, when combined with altered transferrin saturation and serum iron levels.	Iron	86-90	transferrin	Homo sapiens	255-266
7511531-3	1994	In the present study, we show that in vivo the affinity of iron-regulatory factor for iron-responsive elements in liver reflects the long-term iron status of the tissue in animal models for iron overloading and iron deficiency, when combined with altered transferrin saturation and serum iron levels.	Iron	86-90	transferrin	Homo sapiens	255-266
8125919-1	1994	The role of the transferrin receptor in capturing and conveying transferrin through the cell during the iron-donating cycle of receptor-mediated endocytosis has been studied extensively.	Iron	104-108	transferrin	Homo sapiens	16-27
8125919-1	1994	The role of the transferrin receptor in capturing and conveying transferrin through the cell during the iron-donating cycle of receptor-mediated endocytosis has been studied extensively.	Iron	104-108	transferrin	Homo sapiens	64-75
7820145-11	1994	The evolution of the iron metabolism parameters demonstrated an intermitent and statistically significant decrease of transferrin saturation at the 1st, 12th and 24th week, returning to the basal levels at the end of study.	Iron	21-25	transferrin	Homo sapiens	118-129
8142485-7	1994	(C) The removal of iron leads to thermal destabilization of HST, HLF and RST.	Iron	19-23	fibroblast growth factor 4	Homo sapiens	60-63
8119983-1	1994	Cytochrome c3 (M(r) 13,000) is a tetrahemic cytochrome in which the four heme iron atoms are coordinated by 2 histidine residues at the axial positions.	Iron	78-82	cytochrome c, somatic	Homo sapiens	0-12
8119983-3	1994	To investigate this mechanism, four single mutations were introduced in cytochrome c3 by site-directed mutagenesis, leading to the replacement of each histidine, the sixth axial ligand of the heme iron atom, by a methionine residue.	Iron	197-201	cytochrome c, somatic	Homo sapiens	72-84
8125927-2	1994	A transferrin-independent iron transport system in cells containing transferrin receptors was described previously by several investigators.	Iron	26-30	transferrin	Homo sapiens	68-79
8122498-4	1994	At term, the iron treated group had significantly higher Hb, transferrin saturation, S-ferritin (median 22 micrograms/l vs. 14 micrograms/l, (p &lt; 0.0001) and lower S-EPO compared to the placebo treated group.	Iron	13-17	transferrin	Homo sapiens	61-72
8122498-4	1994	At term, the iron treated group had significantly higher Hb, transferrin saturation, S-ferritin (median 22 micrograms/l vs. 14 micrograms/l, (p &lt; 0.0001) and lower S-EPO compared to the placebo treated group.	Iron	13-17	erythropoietin	Homo sapiens	169-172
8122498-7	1994	Newborns to iron treated mothers had higher cord S-ferritin, median 155 micrograms/l, than newborns to placebo treated mothers, median 118 micrograms/l (p &lt; 0.02); there were no differences in birth weight, transferrin saturation, or S-EPO.	Iron	12-16	transferrin	Homo sapiens	210-221
8122498-7	1994	Newborns to iron treated mothers had higher cord S-ferritin, median 155 micrograms/l, than newborns to placebo treated mothers, median 118 micrograms/l (p &lt; 0.02); there were no differences in birth weight, transferrin saturation, or S-EPO.	Iron	12-16	erythropoietin	Homo sapiens	239-242
8311072-10	1994	In association with the glomerular transferrin leak, iron also would be presented to the tubule fluid.	Iron	53-57	transferrin	Homo sapiens	35-46
8160868-14	1994	Iron intake in food was markedly decreased during the 2-wk ascent to 6,542 m. EPO was inversely related to CaO2 and positively related to APR.	Iron	0-4	erythropoietin	Homo sapiens	78-81
8135751-13	1994	Treatment of transfectants with 100 micrograms/ml iron-saturated human transferrin (FeTF) was performed to assess iron responsiveness of the constructs.	Iron	50-54	transferrin	Homo sapiens	71-82
8012557-0	1994	Isolation of the four forms of transferrin with respect to iron by high-performance liquid chromatography: comparison of three mammalian species.	Iron	59-63	transferrin	Homo sapiens	31-42
8012557-1	1994	A method, based on anion exchange combined with high-performance liquid chromatography, is presented for the separation of the four different forms of transferrin with respect to iron, i.e. diferric, monoferric with Fe in the C-terminal lobe, monoferric with Fe in the N-terminal lobe, and apo (iron-free).	Iron	179-183	transferrin	Homo sapiens	151-162
8012557-1	1994	A method, based on anion exchange combined with high-performance liquid chromatography, is presented for the separation of the four different forms of transferrin with respect to iron, i.e. diferric, monoferric with Fe in the C-terminal lobe, monoferric with Fe in the N-terminal lobe, and apo (iron-free).	Iron	216-218	transferrin	Homo sapiens	151-162
8012557-1	1994	A method, based on anion exchange combined with high-performance liquid chromatography, is presented for the separation of the four different forms of transferrin with respect to iron, i.e. diferric, monoferric with Fe in the C-terminal lobe, monoferric with Fe in the N-terminal lobe, and apo (iron-free).	Iron	259-261	transferrin	Homo sapiens	151-162
8012557-1	1994	A method, based on anion exchange combined with high-performance liquid chromatography, is presented for the separation of the four different forms of transferrin with respect to iron, i.e. diferric, monoferric with Fe in the C-terminal lobe, monoferric with Fe in the N-terminal lobe, and apo (iron-free).	Iron	295-299	transferrin	Homo sapiens	151-162
8012557-3	1994	The procedure was also found to free transferrin from loosely bound iron and protein aggregates.	Iron	68-72	transferrin	Homo sapiens	37-48
9371267-2	1994	Molecular mechanisms for the cellular uptake, storage, and utilization of iron were clarified in investigations of the structure and functions of transferrin, transferrin receptor, ferritin, erythroid delta-aminolevulinic acid synthase, and the RNA-binding protein termed the iron responsive-element binding protein.	Iron	74-78	transferrin	Homo sapiens	146-157
9371267-3	1994	Evidence was obtained that a nuclear DNA-binding protein, NF-E2, may be involved in the regulation of both hemoglobin synthesis in erythroid cells and of iron absorption in the intestine.	Iron	154-158	nuclear factor, erythroid 2	Homo sapiens	58-63
8184571-0	1994	[Iron stores in patients with chronic kidney failure treated with recombinant human erythropoietin].	Iron	1-5	erythropoietin	Homo sapiens	84-98
8129715-1	1994	The effect of iron on the exocytosis of transferrin by K562 cells was studied by first allowing the cells to endocytose apotransferrin or diferric transferrin.	Iron	14-18	transferrin	Homo sapiens	40-51
8129715-4	1994	Release of iron-transferrin could be accelerated to a rate comparable with that of apotransferrin by addition of the permeant iron-chelator desferrioxamine.	Iron	11-15	transferrin	Homo sapiens	16-27
8129715-5	1994	The difference in the rates of release of different forms of the protein could be explained by the re-endocytosis of the iron-rich protein, a process detected by the accelerated release of transferrin when the cells were washed in medium at pH 5.5 containing an iron-chelator or treated with a protease-containing medium to digest transferrin accessible at the cell surface.	Iron	121-125	transferrin	Homo sapiens	189-200
8129715-5	1994	The difference in the rates of release of different forms of the protein could be explained by the re-endocytosis of the iron-rich protein, a process detected by the accelerated release of transferrin when the cells were washed in medium at pH 5.5 containing an iron-chelator or treated with a protease-containing medium to digest transferrin accessible at the cell surface.	Iron	121-125	transferrin	Homo sapiens	331-342
8129715-5	1994	The difference in the rates of release of different forms of the protein could be explained by the re-endocytosis of the iron-rich protein, a process detected by the accelerated release of transferrin when the cells were washed in medium at pH 5.5 containing an iron-chelator or treated with a protease-containing medium to digest transferrin accessible at the cell surface.	Iron	262-266	transferrin	Homo sapiens	189-200
8129715-6	1994	It appears that in cells incubated under control conditions, re-endocytosis of transferrin, which is incompletely depleted of iron, occurs and that a transferrin molecule may make two passes through the cell before all the iron is removed.	Iron	126-130	transferrin	Homo sapiens	79-90
8129715-6	1994	It appears that in cells incubated under control conditions, re-endocytosis of transferrin, which is incompletely depleted of iron, occurs and that a transferrin molecule may make two passes through the cell before all the iron is removed.	Iron	223-227	transferrin	Homo sapiens	150-161
8129715-7	1994	This mechanism helps to explain why very little iron-transferrin is released from cells and why the efficiency of the iron uptake process is so high.	Iron	48-52	transferrin	Homo sapiens	53-64
8129715-7	1994	This mechanism helps to explain why very little iron-transferrin is released from cells and why the efficiency of the iron uptake process is so high.	Iron	118-122	transferrin	Homo sapiens	53-64
8311072-13	1994	However, at the reduced pH of tubule fluid iron can dissociate from transferrin and assume a reactive state capable of catalyzing hydroxyl radical formation.	Iron	43-47	transferrin	Homo sapiens	68-79
8194001-1	1994	Seven patients with varying psychiatric disorders were found to have iron overload as manifested by abnormal serum ferritin, transferrin saturation index (TSI), or excessive urinary iron.	Iron	69-73	transferrin	Homo sapiens	125-136
8142226-0	1994	Assessing iron status in children with chronic renal failure on erythropoietin: which measurements should we use?	Iron	10-14	erythropoietin	Homo sapiens	64-78
8299907-9	1994	Transferrin may play an important role in iron delivery to and/or as a growth factor for the rapidly proliferating intestinal epithelium.	Iron	42-46	transferrin	Rattus norvegicus	0-11
8106324-6	1994	Complementation of the pvdA mutation was under stringent iron control; both pyoverdin synthesis and L-Orn N5-oxygenase activity were undetectable in cells of the trans-complemented mutant which had been grown in the presence of 100 microM FeCl3.	Iron	57-61	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	23-27
8106325-9	1994	The deduced amino acid sequence of an open reading frame (ORF1) located downstream from IRP1 was homologous with a family of periplasmic proteins involved in iron transport in gram-negative bacteria and with the ferrichrome receptor, FhuD, from Bacillus subtilis.	Iron	158-162	hypothetical protein	Bacillus subtilis	58-62
8306330-1	1994	The mechanism of action of the clinically used iron(III) chelator, desferrioxamine (DFO), on preventing iron (Fe) uptake from transferrin (Tf) has been investigated using the human melanoma cell line SK-MEL-28.	Iron	47-51	transferrin	Homo sapiens	126-137
8306330-1	1994	The mechanism of action of the clinically used iron(III) chelator, desferrioxamine (DFO), on preventing iron (Fe) uptake from transferrin (Tf) has been investigated using the human melanoma cell line SK-MEL-28.	Iron	110-112	transferrin	Homo sapiens	126-137
8314326-7	1994	For the risk of stomach cancer, we detected inverse relationships with serum iron and with transferrin saturation and a positive relationship with TIBC, but these associations weakened when the cancer cases occurring during the 5 first years of follow-up were excluded.	Iron	77-81	transferrin	Homo sapiens	91-102
7798836-7	1994	By using stepwise multiple regression analysis, the hemoglobin level was shown to significantly determine cardiac enlargement, while ejection fraction and percentage fractional shortening were significantly associated with transferrin-iron saturation.	Iron	235-239	transferrin	Homo sapiens	223-234
7798836-8	1994	Thus, anemia leads to chamber enlargement, while high transferrin iron saturation is associated with cardiac muscle dysfunction.	Iron	66-70	transferrin	Homo sapiens	54-65
8142226-7	1994	We suggest that children with a serum ferritin of 60 micrograms/l or less and those who develop a falling MCV during EPO treatment should receive high-dose oral iron supplementation before and during treatment with EPO.	Iron	161-165	erythropoietin	Homo sapiens	117-120
8139110-5	1994	By electroscopic study, PPO was negative and showed ferritin particles, theta granules and iron containing mitochondria in cytoplasm.	Iron	91-95	protoporphyrinogen oxidase	Homo sapiens	24-27
8290565-1	1994	The iron-responsive element-binding protein (IRE-BP) binds to specific stem-loop RNA structures known as iron-responsive elements (IREs) present in a variety of cellular mRNAs (e.g., those encoding ferritin, erythroid 5-aminolevulinate synthase, and transferrin receptor).	Iron	4-8	transferrin	Homo sapiens	250-261
8165659-6	1994	After the early postnatal iron administration the transferrin-bound Pl rose proportional to the extent of iron resorption from the different preparations.	Iron	26-30	transferrin	Homo sapiens	50-61
8165659-6	1994	After the early postnatal iron administration the transferrin-bound Pl rose proportional to the extent of iron resorption from the different preparations.	Iron	106-110	transferrin	Homo sapiens	50-61
8140077-4	1994	Treatment with erythropoietin (8000 units/day) iron replenishment, corticosteroids and polyvalent immunoglobulins was initiated.	Iron	47-51	erythropoietin	Homo sapiens	15-29
8290565-7	1994	Modeling based on probable structural similarities between the previously crystallized mitochondrial aconitase and the IRE-BP predicts that these residues would be accessible to the IRE only were there a major change in the predicted conformation of the protein when cells are iron-depleted.	Iron	277-281	aconitase 2	Homo sapiens	87-110
8091934-0	1994	Erythropoietin treatment in haemodialysis patients with iron overload.	Iron	56-60	erythropoietin	Homo sapiens	0-14
8305472-4	1994	At pH 7.0, optical and circular dichroism Soret spectra, as well as electron paramagnetic resonance spectra reveal that the heme orientation in the pocket and the coordination state of the ferrous iron in NO-mini-myoglobin are similar to those of the whole protein.	Iron	197-201	myoglobin	Equus caballus	213-222
7762427-4	1994	Uptake of iron from transferrin was rapid, but uptake from lactoferrin was slow, and may have been due to prior transfer of iron to transferrin in the culture medium as a result of labilisation of iron from membrane-bound lactoferrin.	Iron	10-14	transferrin	Homo sapiens	20-31
7976118-2	1994	Erythropoietin (EPO) may lead to iron deficiency; thus, patients who are unable to be phlebotomized due to anemia may benefit from EPO as a treatment of iron overload.	Iron	153-157	erythropoietin	Homo sapiens	16-19
7976118-2	1994	Erythropoietin (EPO) may lead to iron deficiency; thus, patients who are unable to be phlebotomized due to anemia may benefit from EPO as a treatment of iron overload.	Iron	153-157	erythropoietin	Homo sapiens	131-134
7771248-2	1994	While tissue iron uptake occurs by both transferrin-dependent and independent processes, tissue uptake in the iron overload syndromes occurs predominantly via transferrin-independent mechanisms.	Iron	13-17	transferrin	Homo sapiens	40-51
7771248-2	1994	While tissue iron uptake occurs by both transferrin-dependent and independent processes, tissue uptake in the iron overload syndromes occurs predominantly via transferrin-independent mechanisms.	Iron	110-114	transferrin	Homo sapiens	159-170
7976118-0	1994	Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency.	Iron	35-39	erythropoietin	Homo sapiens	0-14
7976118-2	1994	Erythropoietin (EPO) may lead to iron deficiency; thus, patients who are unable to be phlebotomized due to anemia may benefit from EPO as a treatment of iron overload.	Iron	33-37	erythropoietin	Homo sapiens	0-14
7976118-2	1994	Erythropoietin (EPO) may lead to iron deficiency; thus, patients who are unable to be phlebotomized due to anemia may benefit from EPO as a treatment of iron overload.	Iron	33-37	erythropoietin	Homo sapiens	16-19
7976118-2	1994	Erythropoietin (EPO) may lead to iron deficiency; thus, patients who are unable to be phlebotomized due to anemia may benefit from EPO as a treatment of iron overload.	Iron	33-37	erythropoietin	Homo sapiens	131-134
7976118-2	1994	Erythropoietin (EPO) may lead to iron deficiency; thus, patients who are unable to be phlebotomized due to anemia may benefit from EPO as a treatment of iron overload.	Iron	153-157	erythropoietin	Homo sapiens	0-14
7887246-0	1994	Optimized separation and quantitation of serum and cerebrospinal fluid transferrin subfractions defined by differences in iron saturation or glycan composition.	Iron	122-126	transferrin	Homo sapiens	71-82
7762427-6	1994	Lactoferrin significantly reduced uptake of non-transferrin-bound iron by the cells, but had no effect on uptake of transferrin-bound iron.	Iron	66-70	transferrin	Homo sapiens	48-59
7762427-7	1994	Transport of lactoferrin-bound iron across monolayer cultures of differentiated Caco-2 cells in bicameral chambers was similar to that of ferric citrate, while transport of transferrin-bound iron was lower.	Iron	191-195	transferrin	Homo sapiens	173-184
8192527-6	1994	As it is well known correct management of iron supplementation treatment, allows for the significant reduction of r-Hu EPO administration.	Iron	42-46	erythropoietin	Homo sapiens	119-122
8080013-0	1994	Influence of body iron stores on the serum erythropoietin concentration in hemodialyzed patients.	Iron	18-22	erythropoietin	Homo sapiens	43-57
8080013-1	1994	The influence of body iron stores on the concentration of serum erythropoietin was studied in 48 hemodialyzed patients not receiving human recombinant erythropoietin, androgens or iron supplements.	Iron	22-26	erythropoietin	Homo sapiens	64-78
8080013-5	1994	The administration of intravenous iron to the ferropenic patients resulted in a reduction in serum erythropoietin independent of the response of the anemia (18 +/- 13.8 basal and 7.9 +/- 6.5 mIU/ml at 4 weeks, p &lt; 0.01).	Iron	34-38	erythropoietin	Homo sapiens	99-113
7826025-3	1994	The major strategies used by bacteria and fungi to acquire iron include production and utilization of siderophores (ferric specific chelators); utilization of host iron compounds such as heme, transferrin, and lactoferrin; and reduction of Fe(III) to Fe(II) with subsequent transport of Fe(II).	Iron	59-63	transferrin	Homo sapiens	193-204
7508710-0	1994	Receptor-independent uptake of transferrin-bound iron by reticulocytes.	Iron	49-53	transferrin	Homo sapiens	31-42
7508710-1	1994	Under physiological conditions the uptake of transferrin-bound iron by reticulocytes involves transferrin binding to membrane receptors followed by endocytosis, release of iron from the transferrin within endosomes, and recycling of apotransferrin to the cell surface.	Iron	63-67	transferrin	Homo sapiens	45-56
7508710-1	1994	Under physiological conditions the uptake of transferrin-bound iron by reticulocytes involves transferrin binding to membrane receptors followed by endocytosis, release of iron from the transferrin within endosomes, and recycling of apotransferrin to the cell surface.	Iron	63-67	transferrin	Homo sapiens	94-105
7508710-1	1994	Under physiological conditions the uptake of transferrin-bound iron by reticulocytes involves transferrin binding to membrane receptors followed by endocytosis, release of iron from the transferrin within endosomes, and recycling of apotransferrin to the cell surface.	Iron	63-67	transferrin	Homo sapiens	94-105
7508710-1	1994	Under physiological conditions the uptake of transferrin-bound iron by reticulocytes involves transferrin binding to membrane receptors followed by endocytosis, release of iron from the transferrin within endosomes, and recycling of apotransferrin to the cell surface.	Iron	172-176	transferrin	Homo sapiens	45-56
7508710-6	1994	It is concluded that under these incubation conditions iron is released from transferrin at the external surface of the cell and is transported into the cell by a facilitated, possibly active, transport process.	Iron	55-59	transferrin	Homo sapiens	77-88
7998826-3	1994	Iron/hydrogen peroxide-induced DCFH oxidation was inhibited by catalase or by the hydroxyl radical scavenger dimethylsulfoxide; however, superoxide dismutase (SOD) had no effect on DCFH oxidation.	Iron	0-4	catalase	Homo sapiens	63-71
7998826-3	1994	Iron/hydrogen peroxide-induced DCFH oxidation was inhibited by catalase or by the hydroxyl radical scavenger dimethylsulfoxide; however, superoxide dismutase (SOD) had no effect on DCFH oxidation.	Iron	0-4	superoxide dismutase 1	Homo sapiens	159-162
7506082-0	1994	The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake.	Iron	235-239	serpin family A member 1	Homo sapiens	24-43
7506082-10	1994	These data show that alpha 1-AT might be a mediator of the changes in iron metabolism that are characteristic of clinical findings in the course of ACD.	Iron	70-74	serpin family A member 1	Homo sapiens	21-31
7865349-2	1994	In particular, the effect of interferon gamma on human mononuclear phagocyte iron metabolism and the role of iron availability of Legionella pneumophila intracellular multiplication in human monocytes has been elucidated.	Iron	77-81	interferon gamma	Homo sapiens	29-45
8311474-2	1994	The Mossbauer spectra of the iron(III) in diferric transferrin with oxalate have been described using a spin Hamiltonian with the values of the zero field splitting parameter, D = 0.55 +/- 0.05 cm-1, and the rhombicity of the crystal field, E/D = 0.045 +/- 0.005.	Iron	29-33	transferrin	Homo sapiens	51-62
8192528-0	1994	Importance of iron status monitoring during erythropoietin treatment in uremic predialysis patients.	Iron	14-18	erythropoietin	Homo sapiens	44-58
8311474-4	1994	The rhombicity of the iron surroundings for the transferrin-oxalate complex is almost one order of magnitude smaller than for the bicarbonate complex and the zero field splitting parameter is twice as large in the oxalate as in the bicarbonate complex.	Iron	22-26	transferrin	Homo sapiens	48-59
8262649-4	1994	With a dot enzyme assay with biotinylated hemopexin as ligand, H. influenzae bound heme-hemopexin and apo-hemopexin following growth in iron-restricted, but not in iron-sufficient, medium.	Iron	136-140	hemopexin	Oryctolagus cuniculus	88-97
7768202-2	1994	In this review, the normal pattern for iron accumulation and expression of iron regulatory proteins (transferrin and its receptor, and ferritin) in brain during development are examined biochemically and at the cellular and molecular levels.	Iron	75-79	transferrin	Homo sapiens	101-112
7768202-8	1994	These data indicate that iron delivered via transferrin and its receptor is intrinsically involved in oligodendrocyte maturation and thus plays a critical role in the onset of myelination.	Iron	25-29	transferrin	Homo sapiens	44-55
8262649-0	1994	Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b. Heme can serve Haemophilus influenzae as a source of both essential porphyrin and iron.	Iron	42-46	hemopexin	Oryctolagus cuniculus	57-66
7981449-4	1994	Iron metabolism molecules were expressed in abnormal quantities in some breast cancer patients: 27% (13 of 49) had elevated tumor tissue ferritin levels, 4% (2 of 49) had abnormally high serum ferritin, 10% (5 of 49) had abnormally low serum transferrin levels, and 43% (21 of 49) had depressed serum iron levels.	Iron	0-4	transferrin	Homo sapiens	242-253
8131215-1	1994	Myeloperoxidase in the presence of 0.7 mM hydrogen peroxide degrades hyaluronic by a mechanism which involves iron.	Iron	110-114	myeloperoxidase	Homo sapiens	0-15
7950165-0	1994	Iron metabolism and iron substitution during erythropoietin therapy.	Iron	0-4	erythropoietin	Homo sapiens	45-59
7950165-0	1994	Iron metabolism and iron substitution during erythropoietin therapy.	Iron	20-24	erythropoietin	Homo sapiens	45-59
8132241-5	1994	SI, TIBC and percent iron saturation of transferrin are more sensitive indices of iron status and provide us an opportunity to replenish iron stores of an iron deficient pregnant mother at an earlier date thus preventing anaemia.	Iron	21-25	transferrin	Homo sapiens	40-51
8132241-5	1994	SI, TIBC and percent iron saturation of transferrin are more sensitive indices of iron status and provide us an opportunity to replenish iron stores of an iron deficient pregnant mother at an earlier date thus preventing anaemia.	Iron	82-86	transferrin	Homo sapiens	40-51
8132241-5	1994	SI, TIBC and percent iron saturation of transferrin are more sensitive indices of iron status and provide us an opportunity to replenish iron stores of an iron deficient pregnant mother at an earlier date thus preventing anaemia.	Iron	82-86	transferrin	Homo sapiens	40-51
8132241-5	1994	SI, TIBC and percent iron saturation of transferrin are more sensitive indices of iron status and provide us an opportunity to replenish iron stores of an iron deficient pregnant mother at an earlier date thus preventing anaemia.	Iron	82-86	transferrin	Homo sapiens	40-51
8262649-8	1994	Taken together, these observations suggest that H. influenzae type b expresses an outer membrane protein(s) which acts as a receptor for hemopexin and which is regulated by the availability of iron in the growth medium.	Iron	193-197	hemopexin	Oryctolagus cuniculus	137-146
8262649-2	1994	Since H. influenzae grows in the presence of iron-transferrin and heme-hemopexin and is known to express a saturable receptor for transferrin, we investigated the process by which this pathogen acquired heme from hemopexin for use as an iron source.	Iron	45-49	transferrin	Homo sapiens	50-61
8262649-3	1994	The ability of human and rabbit hemopexin to donate heme as a source of iron to H. influenzae type b strains was demonstrated by plate bioassays.	Iron	72-76	hemopexin	Oryctolagus cuniculus	32-41
8262649-4	1994	With a dot enzyme assay with biotinylated hemopexin as ligand, H. influenzae bound heme-hemopexin and apo-hemopexin following growth in iron-restricted, but not in iron-sufficient, medium.	Iron	136-140	hemopexin	Oryctolagus cuniculus	42-51
8262649-4	1994	With a dot enzyme assay with biotinylated hemopexin as ligand, H. influenzae bound heme-hemopexin and apo-hemopexin following growth in iron-restricted, but not in iron-sufficient, medium.	Iron	136-140	hemopexin	Oryctolagus cuniculus	88-97
8139766-8	1994	It is concluded that during the passage of transferrin-bound iron into the brain the iron is released from transferrin within endothelial cells after endocytosis of transferrin.	Iron	61-65	transferrin	Rattus norvegicus	43-54
7769377-4	1994	This indicates that IFN alpha has an effect on the iron-related measurement, partly due to improvement of hepatic status.	Iron	51-55	interferon alpha 1	Homo sapiens	20-29
18476227-1	1994	Transferrin is one of the key proteins of iron metabolism in mammalians.	Iron	42-46	transferrin	Homo sapiens	0-11
8301587-3	1994	Transferrin receptors are highly concentrated on brain blood vessels and participate in the transport of iron across the BBB.	Iron	105-109	transferrin	Rattus norvegicus	0-11
7854209-0	1994	Siderophore-mediated utilization of iron bound to transferrin by Vibrio parahaemolyticus.	Iron	36-40	transferrin	Homo sapiens	50-61
8052364-7	1994	Variations in the level of erythropoiesis among these patients (presumably due to variation in EPO levels, chronic inflammation) strongly influenced the determinants of iron stores (i.e., marrow utilization of iron, transfusion need); iron stores, in turn, influenced MCV.	Iron	169-173	erythropoietin	Homo sapiens	95-98
8139766-8	1994	It is concluded that during the passage of transferrin-bound iron into the brain the iron is released from transferrin within endothelial cells after endocytosis of transferrin.	Iron	61-65	transferrin	Rattus norvegicus	107-118
8139766-8	1994	It is concluded that during the passage of transferrin-bound iron into the brain the iron is released from transferrin within endothelial cells after endocytosis of transferrin.	Iron	61-65	transferrin	Rattus norvegicus	107-118
8139766-8	1994	It is concluded that during the passage of transferrin-bound iron into the brain the iron is released from transferrin within endothelial cells after endocytosis of transferrin.	Iron	85-89	transferrin	Rattus norvegicus	43-54
8139766-8	1994	It is concluded that during the passage of transferrin-bound iron into the brain the iron is released from transferrin within endothelial cells after endocytosis of transferrin.	Iron	85-89	transferrin	Rattus norvegicus	107-118
8139766-8	1994	It is concluded that during the passage of transferrin-bound iron into the brain the iron is released from transferrin within endothelial cells after endocytosis of transferrin.	Iron	85-89	transferrin	Rattus norvegicus	107-118
8260699-6	1993	DFX appears to induce HIF-1 by chelating iron as induction was inhibited by coadministration of ferrous ammonium sulfate.	Iron	41-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-27
10146863-3	1994	Resistance to epoetin may be due to iron or vitamin deficiency, natural or exogenous inhibitors of erythropoiesis and bone marrow fibrosis.	Iron	36-40	erythropoietin	Homo sapiens	14-21
10146863-7	1994	Depletion of iron stores, hypertension, increased blood coagulability and reduced dialyser efficiency resulting from epoetin treatment may all add a small additional component to the true cost.	Iron	13-17	erythropoietin	Homo sapiens	117-124
8116825-0	1993	A new approach to quantitate carbohydrate-deficient transferrin isoforms in alcohol abusers: partial iron saturation in isoelectric focusing/immunoblotting and laser densitometry.	Iron	101-105	transferrin	Homo sapiens	52-63
8116825-2	1993	Isoelectric focusing (IEF) analysis of affinity-purified Tf, under conditions of total iron saturation, identifies a major isoform at pI 5.4 in both normal consumers and alcohol abusers; three additional Tf isoforms (pI 5.6, 5.7, and 5.8) are associated with alcohol abuse.	Iron	87-91	transferrin	Homo sapiens	57-59
8116825-3	1993	Under conditions of partial iron saturation, IEF analysis of affinity-purified Tf reveals up to seven isoforms (pI range 5.3-6.0) common to normal consumers and alcohol abusers; three additional transferrin isoforms (pI range 6.1-6.3) are present in 68% (15/22) of the alcohol abuser specimens, but in only 8% (1/12) of the specimens from normal consumers and in none of the three specimens from abstainers.	Iron	28-32	transferrin	Homo sapiens	79-81
8116825-4	1993	These three diagnostic bands comigrate with a set of defined Tf isoforms: human iron-free Tf containing two sialic acid residues, human sialic acid-free Tf with one iron molecule, and human sialic acid-free, iron-free Tf.	Iron	80-84	transferrin	Homo sapiens	61-63
8116825-4	1993	These three diagnostic bands comigrate with a set of defined Tf isoforms: human iron-free Tf containing two sialic acid residues, human sialic acid-free Tf with one iron molecule, and human sialic acid-free, iron-free Tf.	Iron	80-84	transferrin	Homo sapiens	90-92
8116825-4	1993	These three diagnostic bands comigrate with a set of defined Tf isoforms: human iron-free Tf containing two sialic acid residues, human sialic acid-free Tf with one iron molecule, and human sialic acid-free, iron-free Tf.	Iron	80-84	transferrin	Homo sapiens	90-92
8116825-4	1993	These three diagnostic bands comigrate with a set of defined Tf isoforms: human iron-free Tf containing two sialic acid residues, human sialic acid-free Tf with one iron molecule, and human sialic acid-free, iron-free Tf.	Iron	80-84	transferrin	Homo sapiens	90-92
8059020-4	1994	Proximal tubular iron was related independently with urinary protein and transferrin excretion, suggesting increased cellular uptake of iron from the tubular fluid.	Iron	17-21	transferrin	Homo sapiens	73-84
8059020-4	1994	Proximal tubular iron was related independently with urinary protein and transferrin excretion, suggesting increased cellular uptake of iron from the tubular fluid.	Iron	136-140	transferrin	Homo sapiens	73-84
8262047-0	1993	MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast.	Iron	99-101	Mac1p	Saccharomyces cerevisiae S288C	0-4
8262047-9	1993	This suggests that MAC1 may encode a novel metal-fist transcription factor required for both basal and regulated transcription of genes involved in Cu/Fe utilization and the stress response.	Iron	151-153	Mac1p	Saccharomyces cerevisiae S288C	19-23
8267408-0	1993	Current perspectives: iron management during therapy with recombinant human erythropoietin.	Iron	22-26	erythropoietin	Homo sapiens	76-90
8267412-1	1993	Epoetin alfa stimulates erythropoiesis, thus creating an increased need for iron, and virtually all patients with end-stage renal disease who receive this therapy will eventually require iron supplementation.	Iron	76-80	erythropoietin	Homo sapiens	0-7
8225581-2	1993	Pseudomonas elastase cleavage of transferrin enhances in vitro iron removal from this protein by the P. aeruginosa siderophore pyoverdin.	Iron	63-67	transferrin	Homo sapiens	33-44
8225581-3	1993	This cleavage also generates new iron chelates which, in contrast to iron bound to transferrin, are able to catalyze formation of the highly cytotoxic hydroxyl radical from neutrophil-derived superoxide and hydrogen peroxide via the Haber-Weiss reaction.	Iron	33-37	transferrin	Homo sapiens	83-94
7903343-8	1993	Preculturing of cells in iron- and transferrin-deficient medium prior to 67Ga uptake led to upregulation of the transferrin receptor and a three-fold increase of 67Ga uptake.	Iron	25-29	transferrin	Homo sapiens	112-123
8300902-2	1993	The regulation of systemic iron is through the proteins transferrin (iron mobilization) and ferritin (iron sequestration).	Iron	27-31	transferrin	Rattus norvegicus	56-67
8126248-0	1993	Iron management during treatment with recombinant human erythropoietin in chronic renal failure.	Iron	0-4	erythropoietin	Homo sapiens	56-70
8300902-2	1993	The regulation of systemic iron is through the proteins transferrin (iron mobilization) and ferritin (iron sequestration).	Iron	69-73	transferrin	Rattus norvegicus	56-67
8300902-2	1993	The regulation of systemic iron is through the proteins transferrin (iron mobilization) and ferritin (iron sequestration).	Iron	69-73	transferrin	Rattus norvegicus	56-67
8007816-2	1993	Competition binding experiments demonstrated that, compared to transferrin binding proteins in Neisseria meningitidis, the receptors in M. catarrhalis were more effectively blocked by iron-saturated transferrin than by the apo form of the protein.	Iron	184-188	transferrin	Homo sapiens	63-74
8014927-2	1993	As an iron analog, 111InCl3 binds iron complexing proteins including transferrin.	Iron	6-10	transferrin	Homo sapiens	69-80
8014927-2	1993	As an iron analog, 111InCl3 binds iron complexing proteins including transferrin.	Iron	34-38	transferrin	Homo sapiens	69-80
8159473-1	1993	Human recombinant erythropoietin (rHu-Epo) is now extensively used in chronic renal failures; this treatment, resulting in a correction of the severe anemias seen in hemodialysed patients, may in turn lead to a resistance to rHu-Epo therapy by reason of the shortage of erythropoiesis factors, such as iron, vitamin B12 and folates.	Iron	302-306	erythropoietin	Homo sapiens	18-32
8159473-1	1993	Human recombinant erythropoietin (rHu-Epo) is now extensively used in chronic renal failures; this treatment, resulting in a correction of the severe anemias seen in hemodialysed patients, may in turn lead to a resistance to rHu-Epo therapy by reason of the shortage of erythropoiesis factors, such as iron, vitamin B12 and folates.	Iron	302-306	erythropoietin	Homo sapiens	38-41
8279755-4	1993	Malignant cells requiring more iron modulate a transferrin receptor.	Iron	31-35	transferrin	Homo sapiens	47-58
8279755-5	1993	Iron-bound transferrin interacts with this receptor, facilitating the transport of iron across the cell membrane.	Iron	0-4	transferrin	Homo sapiens	11-22
8279755-5	1993	Iron-bound transferrin interacts with this receptor, facilitating the transport of iron across the cell membrane.	Iron	83-87	transferrin	Homo sapiens	11-22
8007816-2	1993	Competition binding experiments demonstrated that, compared to transferrin binding proteins in Neisseria meningitidis, the receptors in M. catarrhalis were more effectively blocked by iron-saturated transferrin than by the apo form of the protein.	Iron	184-188	transferrin	Homo sapiens	199-210
8007816-3	1993	A combination of direct binding experiments and affinity isolation experiments demonstrated that this was due to a strong preference for binding of iron-saturated transferrin by transferrin binding protein 2 (Tbp2).	Iron	148-152	transferrin	Homo sapiens	163-174
8250840-1	1993	We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937.	Iron	180-184	interleukin 1 beta	Homo sapiens	67-85
8250885-5	1993	In transferrin and iron-free medium stimulation of endothelial cells by bradykinin or thimerosal resulted in a loss of non-heme iron.	Iron	19-23	kininogen 1	Homo sapiens	72-82
8250840-1	1993	We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937.	Iron	180-184	interleukin 1 beta	Homo sapiens	87-96
8250840-1	1993	We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937.	Iron	180-184	tumor necrosis factor	Homo sapiens	129-138
8250840-1	1993	We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937.	Iron	180-184	interferon gamma	Homo sapiens	144-160
8250840-1	1993	We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937.	Iron	180-184	interferon gamma	Homo sapiens	162-171
8250840-4	1993	IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin.	Iron	61-65	interleukin 1 beta	Homo sapiens	0-9
8250840-4	1993	IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin.	Iron	61-65	tumor necrosis factor	Homo sapiens	11-20
8250840-4	1993	IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin.	Iron	61-65	interferon gamma	Homo sapiens	25-34
8250840-4	1993	IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin.	Iron	61-65	transferrin	Homo sapiens	49-60
8250885-5	1993	In transferrin and iron-free medium stimulation of endothelial cells by bradykinin or thimerosal resulted in a loss of non-heme iron.	Iron	128-132	transferrin	Homo sapiens	3-14
8250885-5	1993	In transferrin and iron-free medium stimulation of endothelial cells by bradykinin or thimerosal resulted in a loss of non-heme iron.	Iron	128-132	kininogen 1	Homo sapiens	72-82
8288264-2	1993	Previous attempts to establish a relationship between TF types, serum TF concentrations and iron-binding have been inconclusive.	Iron	92-96	transferrin	Homo sapiens	54-56
8226890-3	1993	Growth arrest of yeast caused by low concentrations of 1,10-phenanthroline, resulting in zinc and/or iron deprivation, is overcome by over-expression of YAP1 or YAP2.	Iron	101-105	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	153-157
8288264-2	1993	Previous attempts to establish a relationship between TF types, serum TF concentrations and iron-binding have been inconclusive.	Iron	92-96	transferrin	Homo sapiens	70-72
8124216-2	1993	A transferrin (Tf)-like iron binding kD 50 protein was found to be the main growth factor of these CM"s.	Iron	24-28	transferrin	Homo sapiens	2-13
8124216-2	1993	A transferrin (Tf)-like iron binding kD 50 protein was found to be the main growth factor of these CM"s.	Iron	24-28	transferrin	Homo sapiens	15-17
8408013-2	1993	We have compared the ability of lactoferrin and transferrin to interact with and donate iron to the monocytic cell line U937.	Iron	88-92	transferrin	Homo sapiens	48-59
8408013-11	1993	It is concluded that transferrin, but not lactoferrin, acts as an iron donor to U937 cells.	Iron	66-70	transferrin	Homo sapiens	21-32
8408013-12	1993	Lactoferrin may regulate uptake of potentially toxic non-transferrin-bound iron.	Iron	75-79	transferrin	Homo sapiens	57-68
8260663-8	1993	The SOD activity of LR strains was irreversibly inhibited 100% by 5 mM H2O2, and exhibited greater sensitivity to NaN3, suggesting the presence of iron in the enzyme.	Iron	147-151	superoxide dismutase 1	Homo sapiens	4-7
8279676-9	1993	Conversely, CCl4 exposure produced a significant 5-fold increase in hepatic iron uptake (p &lt; 0.001).	Iron	76-80	C-C motif chemokine ligand 4	Rattus norvegicus	12-16
8280612-8	1993	These results suggest that transferrin derived endosomal iron may be chelated by HPOs, unlike DFO, due to their faster uptake into these organelles.	Iron	57-61	transferrin	Homo sapiens	27-38
8269969-1	1993	All eukaryotic cells, including African trypanosomes, require iron for growth and division, and this iron is acquired by the receptor-mediated endocytosis of iron-loaded transferrin (diFe(3+)-transferrin).	Iron	62-66	transferrin	Homo sapiens	170-181
8269969-1	1993	All eukaryotic cells, including African trypanosomes, require iron for growth and division, and this iron is acquired by the receptor-mediated endocytosis of iron-loaded transferrin (diFe(3+)-transferrin).	Iron	62-66	transferrin	Homo sapiens	192-203
8269969-1	1993	All eukaryotic cells, including African trypanosomes, require iron for growth and division, and this iron is acquired by the receptor-mediated endocytosis of iron-loaded transferrin (diFe(3+)-transferrin).	Iron	101-105	transferrin	Homo sapiens	170-181
8269969-1	1993	All eukaryotic cells, including African trypanosomes, require iron for growth and division, and this iron is acquired by the receptor-mediated endocytosis of iron-loaded transferrin (diFe(3+)-transferrin).	Iron	101-105	transferrin	Homo sapiens	192-203
8269969-1	1993	All eukaryotic cells, including African trypanosomes, require iron for growth and division, and this iron is acquired by the receptor-mediated endocytosis of iron-loaded transferrin (diFe(3+)-transferrin).	Iron	101-105	transferrin	Homo sapiens	170-181
8269969-1	1993	All eukaryotic cells, including African trypanosomes, require iron for growth and division, and this iron is acquired by the receptor-mediated endocytosis of iron-loaded transferrin (diFe(3+)-transferrin).	Iron	101-105	transferrin	Homo sapiens	192-203
8406363-2	1993	However, recent studies indicate that hepatic parenchymal cells increase the uptake of transferrin-bound iron after in vivo stimulation with bacterial lipopolysaccharide, suggesting that endotoxemia itself or lipopolysaccharide-induced production of inflammation-related cytokines may also be responsible for this phenomenon.	Iron	105-109	transferrin	Homo sapiens	87-98
8406363-3	1993	In this study the actions of inflammation-related cytokines on the synthesis of iron-binding proteins (transferrin and ferritin) and transferrin receptor and the uptake of transferrin-bound iron were investigated in a human hepatoblastoma cell line, HepG2, which is the most commonly used cell line for examining the regulation of hepatic protein synthesis by cytokines.	Iron	80-84	transferrin	Homo sapiens	103-114
8406790-0	1993	Expression of the Haemophilus influenzae transferrin receptor is repressible by hemin but not elemental iron alone.	Iron	104-108	transferrin	Homo sapiens	41-52
8406790-1	1993	The absolute requirement for elemental iron and the porphyrin nucleus for growth of Haemophilus influenzae led us to investigate the role of iron and hemin in regulation of expression of the H. influenzae transferrin receptor.	Iron	141-145	transferrin	Homo sapiens	205-216
8406790-10	1993	These data suggest that the transferrin receptor of H. influenzae is regulated by levels of hemin but not elemental iron alone and that this property is widely distributed among several major cloned families in the species.	Iron	116-120	transferrin	Homo sapiens	28-39
8278082-1	1993	The Authors evaluated the effects and tolerability of iron acetyl transferrin in fifty women affected by anemia for want of iron.	Iron	124-128	transferrin	Homo sapiens	66-77
7934822-1	1993	functions as a periplasmic transport protein in iron acquisition from human transferrin.	Iron	48-52	transferrin	Homo sapiens	76-87
7934822-3	1993	has been proposed to play a central role in the high-affinity acquisition of iron from human transferrin.	Iron	77-81	transferrin	Homo sapiens	93-104
7934822-4	1993	The results of this investigation provide evidence that Fbp participates in this process as a functional analogue of a Gram-negative periplasmic-binding protein component, which operates as a part of a general active transport process for the receptor-mediated, high-affinity transport of iron from human transferrin.	Iron	289-293	transferrin	Homo sapiens	305-316
7934822-6	1993	Predictive of a periplasmic-binding protein, which functions in the high-affinity acquisition of iron, is that Fbp is a transient participant in the process of iron acquisition from human transferrin.	Iron	97-101	transferrin	Homo sapiens	188-199
7934822-6	1993	Predictive of a periplasmic-binding protein, which functions in the high-affinity acquisition of iron, is that Fbp is a transient participant in the process of iron acquisition from human transferrin.	Iron	160-164	transferrin	Homo sapiens	188-199
7934822-9	1993	use a periplasmic-binding protein-mediated active transport mechanism for the acquisition of iron from human transferrin.	Iron	93-97	transferrin	Homo sapiens	109-120
8260663-10	1993	CONCLUSION: Our data indicate that MAC strains are rich in manganese- or iron-containing SOD, which could contribute to the organism"s resistance to the oxidative burst of activated macrophages.	Iron	73-77	superoxide dismutase 1	Homo sapiens	89-92
8396969-0	1993	Characterization of the non-heme iron center of human 5-lipoxygenase by electron paramagnetic resonance, fluorescence, and ultraviolet-visible spectroscopy: redox cycling between ferrous and ferric states.	Iron	33-37	arachidonate 5-lipoxygenase	Homo sapiens	54-68
8396969-1	1993	Purified human 5-lipoxygenase, a non-heme iron containing enzyme, has been characterized by electron paramagnetic resonance, (EPR), ultraviolet (UV)-visible and fluorescence spectroscopy.	Iron	42-46	arachidonate 5-lipoxygenase	Homo sapiens	15-29
7504627-4	1993	NO-induced binding of IRF to iron-responsive elements (IRE) specifically represses the translation of transfected IRE-containing indicator mRNAs as well as the biosynthesis of the cellular iron storage protein ferritin.	Iron	29-33	tripartite motif containing 63	Homo sapiens	22-25
8379943-1	1993	Gallium binds to the iron transport protein transferrin (Tf), is incorporated into cells through transferrin receptors (TfR) and inhibits iron-dependent DNA synthesis.	Iron	21-25	transferrin	Homo sapiens	44-55
8379943-1	1993	Gallium binds to the iron transport protein transferrin (Tf), is incorporated into cells through transferrin receptors (TfR) and inhibits iron-dependent DNA synthesis.	Iron	21-25	transferrin	Homo sapiens	57-59
8360174-7	1993	High level production of either CAD1 or yAP-1 causes cells to acquire a pleiotropic drug-resistant phenotype and to be able to tolerate normally toxic levels of iron chelators and zinc.	Iron	161-165	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	40-45
8396885-4	1993	The reaction was inhibited by sulfhydryl reagents, was heat labile, and may account for reduction of ferric to ferrous iron during hepatic iron uptake from transferrin or from other iron sources.	Iron	139-143	transferrin	Rattus norvegicus	156-167
8358725-5	1993	Neuroblastoma cells treated with DFO adapt appropriately to Fe chelation as measured by marked upregulation of transferrin receptor mRNA, increased functional transferrin receptor, and decreased cellular ferritin concentration.	Iron	60-62	transferrin	Homo sapiens	111-122
8358725-6	1993	Further studies that quantitated cellular incorporation of 59Fe from added transferrin-59Fe in the presence of DFO indicated that neuroblastoma cells were more sensitive to inhibition of Fe incorporation by the chelator as compared to the other cell line.	Iron	61-63	transferrin	Homo sapiens	75-86
7689565-4	1993	Desferrioxamine afforded the cells enriched for catalase modest protection from the toxicities of bleomycin, paraquat, or adriamycin, suggesting that enrichment for iron as a consequence of the increased cellular content of catalase accounted for some of the increased sensitivities.	Iron	165-169	catalase	Homo sapiens	48-56
8214103-6	1993	Catalase (which decomposes hydrogen peroxide), but not heat-inactivated catalase, as well as pyruvate, a potent scavenger of hydrogen peroxide, prevented gentamicin-induced iron mobilization.	Iron	173-177	catalase	Rattus norvegicus	0-8
8396885-4	1993	The reaction was inhibited by sulfhydryl reagents, was heat labile, and may account for reduction of ferric to ferrous iron during hepatic iron uptake from transferrin or from other iron sources.	Iron	119-123	transferrin	Rattus norvegicus	156-167
8396885-4	1993	The reaction was inhibited by sulfhydryl reagents, was heat labile, and may account for reduction of ferric to ferrous iron during hepatic iron uptake from transferrin or from other iron sources.	Iron	139-143	transferrin	Rattus norvegicus	156-167
8364209-1	1993	Agents that interfere with cellular iron (Fe) incorporation inhibit tumor cell proliferation, including metals that bind to transferrin (Tf) such as gallium (Ga) or indium (In) and Fe chelators such as desferrioxamine (DFO).	Iron	36-40	transferrin	Homo sapiens	124-135
8364209-1	1993	Agents that interfere with cellular iron (Fe) incorporation inhibit tumor cell proliferation, including metals that bind to transferrin (Tf) such as gallium (Ga) or indium (In) and Fe chelators such as desferrioxamine (DFO).	Iron	42-44	transferrin	Homo sapiens	124-135
8406123-8	1993	Apparently, the only result of iron complexones and cations on LPO is the decrease of Fe2+ ion concentration on the membrane surface.	Iron	31-35	lactoperoxidase	Homo sapiens	63-66
8360262-5	1993	Diferric transferrin (2Fe.Tf) also is necessary as an iron source (Eby et al.	Iron	54-58	transferrin	Rattus norvegicus	9-20
8244453-0	1993	Chloroquine-induced inhibition of the production of TNF, but not of IL-6, is affected by disruption of iron metabolism.	Iron	103-107	tumor necrosis factor	Homo sapiens	52-55
8244453-8	1993	Our results demonstrated that chloroquine-induced inhibition of TNF and IL-6 production is not mediated through a lysosomotropic mechanism, and that chloroquine probably acts on TNF secretion by disrupting iron homeostasis.	Iron	206-210	tumor necrosis factor	Homo sapiens	178-181
8344986-2	1993	It has recently been shown that RPE cells remove iron from diferric transferrin in a low pH compartment and subsequently release it in a low molecular weight form that can be chelated by apo-transferrin (Hunt and Davis: J.	Iron	49-53	transferrin	Homo sapiens	68-79
8366521-1	1993	Haemophilus influenzae type b expresses an inducible siderophore-independent iron-acquisition system that depends on a direct interaction between human transferrin and specific iron-regulated transferrin-binding outer-membrane proteins.	Iron	77-81	transferrin	Homo sapiens	152-163
8366521-1	1993	Haemophilus influenzae type b expresses an inducible siderophore-independent iron-acquisition system that depends on a direct interaction between human transferrin and specific iron-regulated transferrin-binding outer-membrane proteins.	Iron	77-81	transferrin	Homo sapiens	192-203
8366521-1	1993	Haemophilus influenzae type b expresses an inducible siderophore-independent iron-acquisition system that depends on a direct interaction between human transferrin and specific iron-regulated transferrin-binding outer-membrane proteins.	Iron	177-181	transferrin	Homo sapiens	152-163
8366521-1	1993	Haemophilus influenzae type b expresses an inducible siderophore-independent iron-acquisition system that depends on a direct interaction between human transferrin and specific iron-regulated transferrin-binding outer-membrane proteins.	Iron	177-181	transferrin	Homo sapiens	192-203
8360682-0	1993	Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.	Iron	10-14	amyloid beta precursor protein	Homo sapiens	85-105
8286882-5	1993	There were significant correlations between total liver reserves of vitamin B12 and iron (r = 0.742, p &lt; 0.001), vitamin B12 and copper (r = 0.444, p &lt; 0.001), and iron and copper (r = 0.431, p &lt; 0.001).	Iron	84-88	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	76-79
24227666-3	1993	The charge state of iron in the expelled heme from myoglobin and hemoglobin appears to be 3+ but 2f for heme expelled from cytochrome c.	Iron	20-24	cytochrome c, somatic	Homo sapiens	123-135
8270633-3	1993	Particular attention was given to the transferrin receptor, which plays an important role in cellular iron metabolism.	Iron	102-106	transferrin	Homo sapiens	38-49
8347616-0	1993	The anion requirement for iron release from transferrin is preserved in the receptor-transferrin complex.	Iron	26-30	transferrin	Homo sapiens	44-55
8347616-0	1993	The anion requirement for iron release from transferrin is preserved in the receptor-transferrin complex.	Iron	26-30	transferrin	Homo sapiens	85-96
8347616-1	1993	Rates of iron release from both sites of free transferrin at pH 7.4 are critically dependent upon ionic strength, because release appears to require binding of a simple nonchelating anion such as chloride to a kinetically active site of the protein.	Iron	9-13	transferrin	Homo sapiens	46-57
8347616-3	1993	Complexing of transferrin to its receptor also modulates release of iron, but in a more complex fashion.	Iron	68-72	transferrin	Homo sapiens	14-25
8347616-6	1993	A spectrofluorometric method was developed to monitor release of iron from C-terminal monoferric human transferrin and its complex with the transferrin receptor.	Iron	65-69	transferrin	Homo sapiens	103-114
8347616-7	1993	At pH 5.6, as at pH 7.4, profiles of iron release to pyrophosphate from free and from receptor-complexed monoferric transferrin show curvilinear dependence on pyrophosphate concentration, consistent with a previously described kinetic scheme and suggestive of a similar release mechanism in all cases.	Iron	37-41	transferrin	Homo sapiens	116-127
8345419-2	1993	Iron status was assessed by assaying the serum iron and ferritin levels and the transferrin saturation coefficient as a function of iron intake.	Iron	0-4	transferrin	Homo sapiens	80-91
8343132-1	1993	The effects of single amino acid substitution on the thermal stability of the N-terminal half-molecule of human transferrin and its iron-binding affinity have been studied by high-sensitivity scanning calorimetry.	Iron	132-136	transferrin	Homo sapiens	112-123
8397139-2	1993	Recently, ferric ion chelated to citrate (Fe-citrate) was identified as the major non-transferrin-bound iron in the serum of GH patients.	Iron	104-108	transferrin	Homo sapiens	86-97
8397141-6	1993	The iron-ion reducing ability of apomorphine and laudanosoline was confirmed using cytochrome c.	Iron	4-8	cytochrome c, somatic	Homo sapiens	83-95
8325865-12	1993	Iron unloading is ineffective inside the Belgrade vesicle; 85% of iron that entered on transferrin returned to the medium after exocytosis, whereas only 45% of iron entering normal reticulocytes exits.	Iron	66-70	transferrin	Rattus norvegicus	87-98
8168209-3	1993	The hemolysis, hemoglobin oxidation and lipid peroxidation of erythrocytes induced by hydrogen peroxide and Fe(++)-induced MDA formation of liver microsomes were inhibited by AH-9, and the activity of SOD and catalase were shown to be increased in normal and alloxan-diabetic mice after treatment with AH-9.	Iron	108-114	catalase	Mus musculus	209-217
8358209-0	1993	The effect of lead on iron uptake from transferrin in human erythroleukemia (K562) cells.	Iron	22-26	transferrin	Homo sapiens	39-50
8268603-0	1993	Erythropoietin with oral iron in peritoneal and hemodialysis patients.	Iron	25-29	erythropoietin	Homo sapiens	0-14
8358209-2	1993	When the cells were cultured with 100 microM Pb2+ for 48 h, the rate of cellular iron uptake from transferrin decreased to 46% of that in untreated cells.	Iron	81-85	transferrin	Homo sapiens	98-109
8330354-6	1993	Short-term experiments (5-15 weeks of iron/HCB treatments) showed that GGT and GST-P were induced early in the neoplastic process but not in discrete focal areas.	Iron	38-42	glutathione S-transferase pi 1	Rattus norvegicus	79-84
7686757-1	1993	The involvement of the protoporphyrin IX heme iron of macrophage nitric oxide synthase (NOS) in the oxidation of NG-hydroxy-L-arginine (L-NHA) to nitric oxide (NO) and citrulline was investigated by carbon monoxide (CO) inhibition studies and binding difference spectroscopy.	Iron	46-50	nitric oxide synthase 2	Homo sapiens	65-86
21573321-8	1993	Hb, S-iron, S-transferrin, transferrin saturation and S-ferritin were all significantly correlated to marrow iron grade; S-ferritin, r(s) = 0.64, p &lt;0.0001.	Iron	109-113	transferrin	Homo sapiens	27-38
8345124-0	1993	Iron-binding properties of bovine lactoferrin in iron-rich solution.	Iron	49-53	IRON	Bos taurus	0-4
8320489-1	1993	Accumulation of Fe in the myocardium in circumstances of transferrin saturation is associated with heart failure in Fe-loaded patients.	Iron	16-18	transferrin	Homo sapiens	57-68
8320489-1	1993	Accumulation of Fe in the myocardium in circumstances of transferrin saturation is associated with heart failure in Fe-loaded patients.	Iron	116-118	transferrin	Homo sapiens	57-68
8320489-3	1993	Fe loading with low-molecular-weight Fe (ferric ammonium citrate) promoted a dose- and time-dependent increase in the rate of uptake of non-transferrin-bound Fe (NTBI) that was positively correlated (R = 0.9, p &lt; 0.005) with cellular iron content.	Iron	0-2	transferrin	Homo sapiens	140-151
8320489-3	1993	Fe loading with low-molecular-weight Fe (ferric ammonium citrate) promoted a dose- and time-dependent increase in the rate of uptake of non-transferrin-bound Fe (NTBI) that was positively correlated (R = 0.9, p &lt; 0.005) with cellular iron content.	Iron	37-39	transferrin	Homo sapiens	140-151
8320489-3	1993	Fe loading with low-molecular-weight Fe (ferric ammonium citrate) promoted a dose- and time-dependent increase in the rate of uptake of non-transferrin-bound Fe (NTBI) that was positively correlated (R = 0.9, p &lt; 0.005) with cellular iron content.	Iron	37-39	transferrin	Homo sapiens	140-151
8352231-0	1993	Decreased erythropoietin responsiveness to iron deficiency anemia in the elderly.	Iron	43-47	erythropoietin	Homo sapiens	10-24
8352236-7	1993	Since the rate of erythroid iron uptake is mainly determined by the number of transferrin binding sites, this may explain a decrease in erythroblast iron availability in ACD in RA.	Iron	28-32	transferrin	Homo sapiens	78-89
8352236-7	1993	Since the rate of erythroid iron uptake is mainly determined by the number of transferrin binding sites, this may explain a decrease in erythroblast iron availability in ACD in RA.	Iron	149-153	transferrin	Homo sapiens	78-89
8228124-0	1993	Regulation of ferritin and transferrin receptor expression by iron in human hepatocyte cultures.	Iron	62-66	transferrin	Homo sapiens	27-38
8228124-5	1993	The second step was to study the effect of iron on ferritin and transferrin receptor expression.	Iron	43-47	transferrin	Homo sapiens	64-75
8228124-11	1993	In contrast, transferrin receptor expression was decreased by iron in HepG2 cells as well as in human hepatocyte cultures.	Iron	62-66	transferrin	Homo sapiens	13-24
8515258-11	1993	The results demonstrate that the transferrin receptor on SHSY5Y cells can bind and internalize a manganese-transferrin complex as efficiently as an iron-transferrin complex, although a saturation of the manganese uptake was achieved.	Iron	148-152	transferrin	Homo sapiens	33-44
8515439-2	1993	Recent X-ray crystallographic and solution X-ray scattering studies have shown that transferrins (serum transferrin, lactoferrin and ovotransferrin) undergo a major conformational change when iron is incorporated into the molecule.	Iron	192-196	transferrin	Homo sapiens	84-95
8518276-0	1993	Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase L-1.	Iron	50-54	seed linoleate 13S-lipoxygenase-1	Glycine max	82-98
8518276-1	1993	Five ligands of the active site iron atom in soybean lipoxygenase L-1 have been identified from the electron density map of the crystallized enzyme.	Iron	32-36	seed linoleate 13S-lipoxygenase-1	Glycine max	53-69
8507877-4	1993	When succinylacetone is used to inhibit Belgrade heme synthesis, iron from diferric transferrin does not accumulate in the stromal fraction that contains mitochondria, nor does 59Fe accumulate in the nonheme cytosolic fraction.	Iron	65-69	transferrin	Rattus norvegicus	84-95
8507877-6	1993	Therefore, the mutation affects either the release of iron from transferrin or iron transport from the vesicle to the mitochondrion.	Iron	54-58	transferrin	Rattus norvegicus	64-75
8330305-5	1993	Lipid peroxidation induced by myricetin was significantly inhibited only by SOD in the presence of copper (II), whereas it was enhanced by catalase and sodium azide in the presence of iron (III).	Iron	184-188	catalase	Rattus norvegicus	139-147
8333587-1	1993	Transferrin is N-glycosylated glycoprotein and plays an important role in iron transport from sites of absorption and storage to sites of utilization.	Iron	74-78	transferrin	Rattus norvegicus	0-11
8492137-2	1993	Because neuronal and glial iron uptake seems to be mediated by the binding of ferrotransferrin to a specific high-affinity receptor on the cell surface, the number of transferrin receptors could be altered in this disease.	Iron	27-31	transferrin	Homo sapiens	83-94
8503735-3	1993	In 10 patients with possible iron deficiency, a significant rise in serum iron level and transferrin saturation occurred during the 24 hours following transfusion, which persisted at a marginally significant level up to 36 hours.	Iron	29-33	transferrin	Homo sapiens	89-100
8503735-6	1993	These data show that the diagnosis of iron deficiency (based on a transferrin saturation of &lt; 0.16) might be missed if iron studies are performed on patients within 24 hours following packed red blood cell transfusion.	Iron	38-42	transferrin	Homo sapiens	66-77
8344331-4	1993	The key pathophysiologic factor may be the increase of gut-derived non-transferrin bound iron liganded to low-molecular mass organic molecules.	Iron	89-93	transferrin	Homo sapiens	71-82
8344331-5	1993	A putative membrane carrier protein for non-transferrin bound iron was identified and preliminary data suggest its enrichment in plasma membranes of human mucosal cells as well as in liver and other organs which are affected in genetic haemochromatosis.	Iron	62-66	transferrin	Homo sapiens	44-55
7691783-6	1993	Furthermore the higher sensitivity of the method was assessed using nitrocellulose filters containing serially diluted iron-saturated transferrin.	Iron	119-123	transferrin	Homo sapiens	134-145
8492137-6	1993	These results show that in the mesencephalon the regional density of transferrin binding sites is lowest in the dopaminergic cell groups, which are the most vulnerable to PD, and suggest that iron does not accumulate through an increased density of transferrin receptors at the level of the substantia nigra.	Iron	192-196	transferrin	Homo sapiens	69-80
8510137-5	1993	Iron-restriction induced by human transferrin (HTF) resulted in almost equal amounts of the two tRNA(trp) species (P1 congruent to P2).	Iron	0-4	transferrin	Homo sapiens	34-45
8378585-4	1993	A deterioration of the iron donating function of the Fe/Transferrin complex caused by malnutrition, is postulated.	Iron	23-27	transferrin	Homo sapiens	56-67
8501464-7	1993	Apparent distances between the heme iron of lactoperoxidase and either the carbon or nitrogen atoms of bound thiocyanate ion have been determined through application of the Solomon-Bloembergen equation.	Iron	36-40	lactoperoxidase	Homo sapiens	44-59
8501775-2	1993	In patients undergoing hemodialysis the administration of recombinant human erythropoietin improves anemia with a decrease in bodily iron stores.	Iron	133-137	erythropoietin	Homo sapiens	76-90
8361358-1	1993	Iron-saturated human transferrin was digested with either chymotrypsin or trypsin to produce C-lobe and N-lobe protein fragments.	Iron	0-4	transferrin	Homo sapiens	21-32
8371846-2	1993	Iron is distributed to different cell types in the brain in a heterogeneous fashion through the action of transferrin, transferrin receptors, and the metabolic needs of those cells.	Iron	0-4	transferrin	Homo sapiens	106-117
8331139-5	1993	Unfolding intermediates of the isoforms, which interconvert to the unfolded state slowly compared with the time scale of the electrophoretic separation, and also the completely unfolded isoforms were resolved and detected simultaneously when iron-free transferrin was subjected to denaturation by urea at concentrations between 3 and 6 M. However, no unfolding intermediates were observed with transferrin isoforms containing two iron atoms (i.e. diferric transferrin molecules), which accordingly are strongly resistant to urea denaturation.	Iron	242-246	transferrin	Homo sapiens	252-263
8331139-5	1993	Unfolding intermediates of the isoforms, which interconvert to the unfolded state slowly compared with the time scale of the electrophoretic separation, and also the completely unfolded isoforms were resolved and detected simultaneously when iron-free transferrin was subjected to denaturation by urea at concentrations between 3 and 6 M. However, no unfolding intermediates were observed with transferrin isoforms containing two iron atoms (i.e. diferric transferrin molecules), which accordingly are strongly resistant to urea denaturation.	Iron	242-246	transferrin	Homo sapiens	394-405
8331139-5	1993	Unfolding intermediates of the isoforms, which interconvert to the unfolded state slowly compared with the time scale of the electrophoretic separation, and also the completely unfolded isoforms were resolved and detected simultaneously when iron-free transferrin was subjected to denaturation by urea at concentrations between 3 and 6 M. However, no unfolding intermediates were observed with transferrin isoforms containing two iron atoms (i.e. diferric transferrin molecules), which accordingly are strongly resistant to urea denaturation.	Iron	242-246	transferrin	Homo sapiens	394-405
8331139-5	1993	Unfolding intermediates of the isoforms, which interconvert to the unfolded state slowly compared with the time scale of the electrophoretic separation, and also the completely unfolded isoforms were resolved and detected simultaneously when iron-free transferrin was subjected to denaturation by urea at concentrations between 3 and 6 M. However, no unfolding intermediates were observed with transferrin isoforms containing two iron atoms (i.e. diferric transferrin molecules), which accordingly are strongly resistant to urea denaturation.	Iron	430-434	transferrin	Homo sapiens	252-263
8331139-6	1993	The unfolding of the transferrin isoforms depends on the iron content of the complexes, but not the carbohydrate content.	Iron	57-61	transferrin	Homo sapiens	21-32
7685392-1	1993	Ferritin and transferrin receptors are co-ordinately regulated by the same RNA-protein interaction: the conserved iron regulatory element (IRE) in mRNA and the IRE-binding protein (IRE-BP/IRP/FRP/P-90).	Iron	114-118	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	192-195
8361638-1	1993	The role of oligodendrocyte-derived transferrin in the transport and regional accumulation of iron has been studied in myelin-deficient (md) rats, which lack functional oligodendrocytes and have an almost complete depletion of transferrin in the brain, although they have normal peripheral levels of transferrin.	Iron	94-98	transferrin	Rattus norvegicus	36-47
8361638-5	1993	The choroid plexus contains high levels of transferrin mRNA and it is therefore likely that transferrin synthesized by choroid plexus epithelial cells can mediate the transport of iron within the brain.	Iron	180-184	transferrin	Rattus norvegicus	43-54
8494052-6	1993	LF is an iron scavenger and a complement inhibitor.	Iron	9-13	lactotransferrin	Homo sapiens	0-2
8361638-5	1993	The choroid plexus contains high levels of transferrin mRNA and it is therefore likely that transferrin synthesized by choroid plexus epithelial cells can mediate the transport of iron within the brain.	Iron	180-184	transferrin	Rattus norvegicus	92-103
7683652-7	1993	Interaction at site 1 reduces the responsiveness of the enzyme to activation by calmodulin, whereas interaction at site 2 (involving putative binding of the imidazole to the heme iron) reduces the maximal velocity of citrulline formation.	Iron	179-183	calmodulin 1	Homo sapiens	80-90
8490018-0	1993	Posttranscriptional regulation of chimeric human transferrin genes by iron.	Iron	70-74	transferrin	Homo sapiens	49-60
8490018-1	1993	Transferrin, the transferrin receptor, and ferritin are integral to the body"s management of iron, an element required for life but highly toxic when present in excess.	Iron	93-97	transferrin	Homo sapiens	0-11
8490018-1	1993	Transferrin, the transferrin receptor, and ferritin are integral to the body"s management of iron, an element required for life but highly toxic when present in excess.	Iron	93-97	transferrin	Homo sapiens	17-28
8490018-2	1993	The transferrin receptor and ferritin are regulated posttranscriptionally by iron: the transferrin receptor by mRNA stability and ferritin by mRNA translation.	Iron	77-81	transferrin	Homo sapiens	4-15
8490018-2	1993	The transferrin receptor and ferritin are regulated posttranscriptionally by iron: the transferrin receptor by mRNA stability and ferritin by mRNA translation.	Iron	77-81	transferrin	Homo sapiens	87-98
8490018-3	1993	Results described here indicate that transferrin, like ferritin, is regulated by iron at the level of translation.	Iron	81-85	transferrin	Homo sapiens	37-48
8490018-6	1993	Binding of specific RNA iron regulatory elements by proteins in cytoplasmic extracts have been shown to regulate ferritin and transferrin receptor synthesis.	Iron	24-28	transferrin	Homo sapiens	126-137
8490018-8	1993	A decreased binding of human transferrin 5"-untranslated region RNA by factors in cytoplasmic extracts of livers from mice receiving iron was found when compared to extracts from control mice.	Iron	133-137	transferrin	Homo sapiens	29-40
8490018-10	1993	The ferritin iron responsive element RNA also competed with the human transferrin 5"-untranslated region RNA-protein complexes formed and vice versa.	Iron	13-17	transferrin	Homo sapiens	70-81
8490018-11	1993	Therefore, iron modulation of human transferrin may share a factor common or similar to that observed in ferritin and transferrin receptor iron modulation.	Iron	11-15	transferrin	Homo sapiens	36-47
8490018-11	1993	Therefore, iron modulation of human transferrin may share a factor common or similar to that observed in ferritin and transferrin receptor iron modulation.	Iron	139-143	transferrin	Homo sapiens	118-129
8396192-5	1993	This contrasts with bacterial transferrin receptors, which only bind to C-lobe fragment of human transferrin, indicating that the bacterial lactoferrin and transferrin receptors differ in their interaction with their respective glycoprotein ligands and may differ in the mechanism of iron removal.	Iron	284-288	transferrin	Homo sapiens	30-41
8481230-2	1993	In vitro studies from our laboratory demonstrated that alveolar and interstitial macrophages treated with iron and asbestos release platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) into the media.	Iron	106-110	transforming growth factor, beta 1	Rattus norvegicus	207-215
8396192-5	1993	This contrasts with bacterial transferrin receptors, which only bind to C-lobe fragment of human transferrin, indicating that the bacterial lactoferrin and transferrin receptors differ in their interaction with their respective glycoprotein ligands and may differ in the mechanism of iron removal.	Iron	284-288	transferrin	Homo sapiens	97-108
8396192-5	1993	This contrasts with bacterial transferrin receptors, which only bind to C-lobe fragment of human transferrin, indicating that the bacterial lactoferrin and transferrin receptors differ in their interaction with their respective glycoprotein ligands and may differ in the mechanism of iron removal.	Iron	284-288	transferrin	Homo sapiens	97-108
8514118-0	1993	Utilization of transferrin-bound iron by Listeria monocytogenes.	Iron	33-37	transferrin	Homo sapiens	15-26
8473296-0	1993	Characterization of transferrin-independent iron transport in K562 cells.	Iron	44-48	transferrin	Homo sapiens	20-31
8514118-1	1993	It has been demonstrated that under iron-restricted conditions, Listeria monocytogenes can utilize iron-loaded transferrin (Tf) from a range of species as its sole source of iron for growth.	Iron	36-40	transferrin	Homo sapiens	111-122
8514118-1	1993	It has been demonstrated that under iron-restricted conditions, Listeria monocytogenes can utilize iron-loaded transferrin (Tf) from a range of species as its sole source of iron for growth.	Iron	99-103	transferrin	Homo sapiens	111-122
8514118-1	1993	It has been demonstrated that under iron-restricted conditions, Listeria monocytogenes can utilize iron-loaded transferrin (Tf) from a range of species as its sole source of iron for growth.	Iron	99-103	transferrin	Homo sapiens	111-122
8514118-3	1993	This binding was blocked by apotransferrin indicating that the receptor can bind transferrin in either the iron-bound or iron-free form.	Iron	107-111	transferrin	Homo sapiens	31-42
7682707-7	1993	To demonstrate the validity of this strategy, we have used RNase T1 treatment of permeabilized cells and RLPCR and have detected in vivo iron-depletion-dependent footprints on two iron-responsive elements of the transferrin receptor mRNA.	Iron	137-141	transferrin	Homo sapiens	212-223
8514118-3	1993	This binding was blocked by apotransferrin indicating that the receptor can bind transferrin in either the iron-bound or iron-free form.	Iron	121-125	transferrin	Homo sapiens	31-42
7682707-7	1993	To demonstrate the validity of this strategy, we have used RNase T1 treatment of permeabilized cells and RLPCR and have detected in vivo iron-depletion-dependent footprints on two iron-responsive elements of the transferrin receptor mRNA.	Iron	180-184	transferrin	Homo sapiens	212-223
8485208-5	1993	Marrow iron was correlated to S-ferritin (rho = 0.53, p = 0.0001), mean red cell volume (rho = 0.34, p = 0.003), and S-transferrin (rho = -0.24, p = 0.02).	Iron	7-11	transferrin	Homo sapiens	119-130
8385904-2	1993	Hepatocytes exposed to IFN-gamma, TNF-alpha, IL-1 beta, and LPS demonstrated the appearance of a g = 2.04 axial EPR signal indicative of the formation of nonheme iron-nitrosyl complexes.	Iron	162-166	tumor necrosis factor	Rattus norvegicus	34-43
8493994-1	1993	Mild hepatic iron overload has been demonstrated by magnetic susceptibility measurements in a 22-year-old man with hereditary sideroblastic erythropoiesis despite hemoglobin levels in the normal range and a normal erythropoietin level.	Iron	13-17	erythropoietin	Homo sapiens	214-228
8390307-1	1993	The electron paramagnetic resonance (EPR) low-temperature spectra of high spin ferric myoglobin samples in different solvent composition have been analyzed in terms of a distribution of the energy differences delta 1 and delta 2 for the iron low-lying electronic states.	Iron	237-241	delta like non-canonical Notch ligand 1	Homo sapiens	209-226
8385904-2	1993	Hepatocytes exposed to IFN-gamma, TNF-alpha, IL-1 beta, and LPS demonstrated the appearance of a g = 2.04 axial EPR signal indicative of the formation of nonheme iron-nitrosyl complexes.	Iron	162-166	interleukin 1 beta	Rattus norvegicus	45-54
8390307-3	1993	A dedicated analysis based on the angular overlap method (AOM) has allowed us to work out a quantitative relationship between the delta 1 and delta 2 distributions and the spread of the iron-heme displacement; this being a structural parameter relevant for the biological functionality of the protein.	Iron	186-190	delta like non-canonical Notch ligand 1	Homo sapiens	130-147
8454351-6	1993	One hundred micromolar ferrous sulfate antagonized IFN-gamma-LPS activation of splenic macrophages, indicating that iron was involved in the fungistatic activity of cytokine-stimulated phagocytes.	Iron	116-120	interferon gamma	Mus musculus	51-60
8388290-0	1993	[Exogenous iron as a factor determining the effect of tumor necrosis factor (TNF) on the Raji cell line].	Iron	11-15	tumor necrosis factor	Homo sapiens	54-75
8388290-0	1993	[Exogenous iron as a factor determining the effect of tumor necrosis factor (TNF) on the Raji cell line].	Iron	11-15	tumor necrosis factor	Homo sapiens	77-80
8477715-0	1993	Influence of conjugation of doxorubicin to transferrin on the iron uptake by K562 cells via receptor-mediated endocytosis.	Iron	62-66	transferrin	Homo sapiens	43-54
8477715-9	1993	Results obtained for the endocytosis of, the iron uptake from, and the recycling of double-labelled ligands indicate that (a) the rate of iron uptake is smaller from conjugates than from transferrin, (b) there are at least two parallel recycling processes for both ligand.receptor complexes, and (c) each time constant characterizing the different steps of iron uptake via receptor-mediated endocytosis is smaller for conjugates than for transferrin (or, the half times characterizing the different steps are higher for conjugates than for transferrin).	Iron	138-142	transferrin	Homo sapiens	187-198
8477715-9	1993	Results obtained for the endocytosis of, the iron uptake from, and the recycling of double-labelled ligands indicate that (a) the rate of iron uptake is smaller from conjugates than from transferrin, (b) there are at least two parallel recycling processes for both ligand.receptor complexes, and (c) each time constant characterizing the different steps of iron uptake via receptor-mediated endocytosis is smaller for conjugates than for transferrin (or, the half times characterizing the different steps are higher for conjugates than for transferrin).	Iron	138-142	transferrin	Homo sapiens	438-449
8477715-9	1993	Results obtained for the endocytosis of, the iron uptake from, and the recycling of double-labelled ligands indicate that (a) the rate of iron uptake is smaller from conjugates than from transferrin, (b) there are at least two parallel recycling processes for both ligand.receptor complexes, and (c) each time constant characterizing the different steps of iron uptake via receptor-mediated endocytosis is smaller for conjugates than for transferrin (or, the half times characterizing the different steps are higher for conjugates than for transferrin).	Iron	138-142	transferrin	Homo sapiens	438-449
8477715-9	1993	Results obtained for the endocytosis of, the iron uptake from, and the recycling of double-labelled ligands indicate that (a) the rate of iron uptake is smaller from conjugates than from transferrin, (b) there are at least two parallel recycling processes for both ligand.receptor complexes, and (c) each time constant characterizing the different steps of iron uptake via receptor-mediated endocytosis is smaller for conjugates than for transferrin (or, the half times characterizing the different steps are higher for conjugates than for transferrin).	Iron	138-142	transferrin	Homo sapiens	187-198
8477715-9	1993	Results obtained for the endocytosis of, the iron uptake from, and the recycling of double-labelled ligands indicate that (a) the rate of iron uptake is smaller from conjugates than from transferrin, (b) there are at least two parallel recycling processes for both ligand.receptor complexes, and (c) each time constant characterizing the different steps of iron uptake via receptor-mediated endocytosis is smaller for conjugates than for transferrin (or, the half times characterizing the different steps are higher for conjugates than for transferrin).	Iron	138-142	transferrin	Homo sapiens	438-449
8477715-9	1993	Results obtained for the endocytosis of, the iron uptake from, and the recycling of double-labelled ligands indicate that (a) the rate of iron uptake is smaller from conjugates than from transferrin, (b) there are at least two parallel recycling processes for both ligand.receptor complexes, and (c) each time constant characterizing the different steps of iron uptake via receptor-mediated endocytosis is smaller for conjugates than for transferrin (or, the half times characterizing the different steps are higher for conjugates than for transferrin).	Iron	138-142	transferrin	Homo sapiens	438-449
8500917-8	1993	Although in the first month the reference treatment appears to provide somewhat faster results, significantly greater values of blood iron are observed at the end of the observation in the ITF 282 group, indicating a more progressive and steady therapeutic effect.	Iron	134-138	trefoil factor 3	Homo sapiens	189-192
8500917-13	1993	Therefore, the good clinical tolerability of ITF 282 effectively removed one of the main obstacles to the correct compliance with iron treatments (necessarily to be taken long-term), as reduced the risks of undesired events in a particularly susceptible population subgroup, such as children.	Iron	130-134	trefoil factor 3	Homo sapiens	45-48
8324080-1	1993	The effect of iron on the cytotoxicity of tumour necrosis factor-alpha (TNF, cachectin) was examined in L929 cells, which are killed by TNF at low concentrations.	Iron	14-18	tumor necrosis factor	Mus musculus	72-75
8384229-6	1993	We found that cytochrome c(c)covalently coupled to monovalent iron-saturated transferrin (Tf), (c-Tf), is not processed or presented significantly better than unconjugated c, indicating that the majority of cycling TfR does not enter compartments where processing proceeds.	Iron	62-66	cytochrome c, somatic	Homo sapiens	14-26
8384229-6	1993	We found that cytochrome c(c)covalently coupled to monovalent iron-saturated transferrin (Tf), (c-Tf), is not processed or presented significantly better than unconjugated c, indicating that the majority of cycling TfR does not enter compartments where processing proceeds.	Iron	62-66	transferrin	Homo sapiens	77-88
8384229-6	1993	We found that cytochrome c(c)covalently coupled to monovalent iron-saturated transferrin (Tf), (c-Tf), is not processed or presented significantly better than unconjugated c, indicating that the majority of cycling TfR does not enter compartments where processing proceeds.	Iron	62-66	transferrin	Homo sapiens	90-92
8384229-6	1993	We found that cytochrome c(c)covalently coupled to monovalent iron-saturated transferrin (Tf), (c-Tf), is not processed or presented significantly better than unconjugated c, indicating that the majority of cycling TfR does not enter compartments where processing proceeds.	Iron	62-66	nuclear factor I C	Homo sapiens	96-100
8324080-1	1993	The effect of iron on the cytotoxicity of tumour necrosis factor-alpha (TNF, cachectin) was examined in L929 cells, which are killed by TNF at low concentrations.	Iron	14-18	tumor necrosis factor	Mus musculus	77-86
8324080-2	1993	In L929 cells, the addition of iron (FeNTA) either prior to or concurrent with the addition of TNF markedly augmented the cytotoxicity of TNF over a wide range of TNF concentrations.	Iron	31-35	tumor necrosis factor	Mus musculus	138-141
8324080-2	1993	In L929 cells, the addition of iron (FeNTA) either prior to or concurrent with the addition of TNF markedly augmented the cytotoxicity of TNF over a wide range of TNF concentrations.	Iron	31-35	tumor necrosis factor	Mus musculus	138-141
8324080-4	1993	The iron chelator deferoxamine was able to protect against TNF cytotoxicity in L929 cells.	Iron	4-8	tumor necrosis factor	Mus musculus	59-62
8324080-5	1993	Iron chelators also protected L929 cells from the cytotoxicity of TNF plus cycloheximide, suggesting that iron plays a role in this mode of TNF killing as well.	Iron	0-4	tumor necrosis factor	Mus musculus	66-69
8324080-5	1993	Iron chelators also protected L929 cells from the cytotoxicity of TNF plus cycloheximide, suggesting that iron plays a role in this mode of TNF killing as well.	Iron	0-4	tumor necrosis factor	Mus musculus	140-143
8324080-5	1993	Iron chelators also protected L929 cells from the cytotoxicity of TNF plus cycloheximide, suggesting that iron plays a role in this mode of TNF killing as well.	Iron	106-110	tumor necrosis factor	Mus musculus	66-69
8324080-5	1993	Iron chelators also protected L929 cells from the cytotoxicity of TNF plus cycloheximide, suggesting that iron plays a role in this mode of TNF killing as well.	Iron	106-110	tumor necrosis factor	Mus musculus	140-143
8324080-7	1993	These experiments demonstrate that cellular iron status affects the ability of TNF to kill sensitive target cells.	Iron	44-48	tumor necrosis factor	Mus musculus	79-82
8456113-6	1993	These effects are considered to be due to the action of heme, metalloporphyrins, iron, or heme byproducts on the IFN-gamma signal, rather than to direct effects on IFN-gamma-induced enzymatic pathways.	Iron	81-85	interferon gamma	Homo sapiens	113-122
8350509-0	1993	[Assay of erythropoietin in serum with short term enzyme linked immunosorbent assay method--the clinical significance: Part 2--:Relation to serum iron, UIBC and ferritin in renal failure and hematological disorders].	Iron	146-150	erythropoietin	Homo sapiens	10-24
8350509-2	1993	In this report, the EPO data were analysed in relation to serum iron concentrations, with ferritin and UIBC.	Iron	64-68	erythropoietin	Homo sapiens	20-23
8350509-5	1993	One was in patients with iron deficiency anemia, whose serum EPO was negatively correlated to serum iron (r = -0.64) and ferritin (r = -0.59), but positively related to UIBC (r = 0.27).	Iron	25-29	erythropoietin	Homo sapiens	61-64
8350509-6	1993	The another was the pattern in patients with aplastic anemia, leukemia and MDS, whose serum EPO positively correlated to iron and ferritin but negatively correlated to UIBC.	Iron	121-125	erythropoietin	Homo sapiens	92-95
8350509-7	1993	In the patients with aplastic anemia serum EPO had good correlation to serum iron (r = 0.62), ferritin (r = 0.60) and UIBC (r = -0.46).	Iron	77-81	erythropoietin	Homo sapiens	43-46
8350509-8	1993	The relationship of EPO to iron in the patients with leukemia (r = 0.54), and EPO to ferritin in the patients with MDS (r = 0.42) show significantly positive correlation coefficient.	Iron	27-31	erythropoietin	Homo sapiens	20-23
7681064-0	1993	Identification of the histidine residues of hemopexin that coordinate with heme-iron and of a receptor-binding region.	Iron	80-84	hemopexin	Oryctolagus cuniculus	44-53
8457605-5	1993	Results are compatible with increased degradation of membrane-translocated PKC, possibly by iron/H2O2-mediated damage of cysteine-rich regulatory domains of PKC.	Iron	92-96	proline rich transmembrane protein 2	Homo sapiens	75-78
8457605-5	1993	Results are compatible with increased degradation of membrane-translocated PKC, possibly by iron/H2O2-mediated damage of cysteine-rich regulatory domains of PKC.	Iron	92-96	proline rich transmembrane protein 2	Homo sapiens	157-160
8456113-2	1993	In this study, we compared the effects of heme, several metalloporphyrins, protoporphyrin IX, and iron on the signal or IFN-gamma-mediated pathways, such as the expression of major histocompatibility complex class II antigens, neopterin formation, and the degradation of tryptophan.	Iron	98-102	interferon gamma	Homo sapiens	120-129
8456113-3	1993	Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-gamma signal.	Iron	126-130	GLI family zinc finger 2	Homo sapiens	37-42
8456113-3	1993	Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-gamma signal.	Iron	126-130	interferon gamma	Homo sapiens	161-170
8468108-1	1993	A prospective, controlled, double-blind, double-dummy, multicenter clinical trial was made to assess the efficacy and tolerability of iron-protein-succinylate (ITF 282) in comparison with a well known iron preparation in the treatment of iron deficiency or iron deficient anemia.	Iron	134-138	trefoil factor 3	Homo sapiens	160-163
8449958-0	1993	Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.	Iron	60-64	5'-aminolevulinate synthase 1	Homo sapiens	25-51
8020729-1	1993	In convalescents after and in patients with sepsis, purulent meningoencephalitis, severe pneumonia the study of iron metabolism provided biochemical criteria of iron excess: low serum transferrin against high transferrin iron, elevated ferritin.	Iron	161-165	transferrin	Homo sapiens	184-195
8447283-1	1993	The transferrin receptor is expressed on the surface of rapidly dividing cells that require iron as a co-factor for essential redox reactions and deoxyribonucleotide synthesis.	Iron	92-96	transferrin	Homo sapiens	4-15
8020729-1	1993	In convalescents after and in patients with sepsis, purulent meningoencephalitis, severe pneumonia the study of iron metabolism provided biochemical criteria of iron excess: low serum transferrin against high transferrin iron, elevated ferritin.	Iron	112-116	transferrin	Homo sapiens	184-195
8020729-1	1993	In convalescents after and in patients with sepsis, purulent meningoencephalitis, severe pneumonia the study of iron metabolism provided biochemical criteria of iron excess: low serum transferrin against high transferrin iron, elevated ferritin.	Iron	161-165	transferrin	Homo sapiens	184-195
8450071-1	1993	Coordinate upregulation by iron transferrin and downregulation by interferon gamma.	Iron	27-31	transferrin	Homo sapiens	32-43
8450071-2	1993	We have investigated the regulation of key human iron binding proteins in mononuclear phagocytes by IFN gamma and iron transferrin.	Iron	49-53	interferon gamma	Homo sapiens	100-109
8450071-2	1993	We have investigated the regulation of key human iron binding proteins in mononuclear phagocytes by IFN gamma and iron transferrin.	Iron	49-53	transferrin	Homo sapiens	119-130
8450071-3	1993	In a previous study, we demonstrated that IFN gamma downregulates the expression on human monocytes of transferrin receptors, the major source of iron for the cell.	Iron	146-150	interferon gamma	Homo sapiens	42-51
8450071-3	1993	In a previous study, we demonstrated that IFN gamma downregulates the expression on human monocytes of transferrin receptors, the major source of iron for the cell.	Iron	146-150	transferrin	Homo sapiens	103-114
8450071-4	1993	In the present study, we show that IFN gamma also downregulates the intracellular concentration of ferritin, the major iron storage protein in the cell.	Iron	119-123	interferon gamma	Homo sapiens	35-44
8450071-6	1993	Consistent with its downregulating effect on these iron proteins, IFN gamma treatment also results in decreased iron incorporation.	Iron	51-55	interferon gamma	Homo sapiens	66-75
8450071-6	1993	Consistent with its downregulating effect on these iron proteins, IFN gamma treatment also results in decreased iron incorporation.	Iron	112-116	interferon gamma	Homo sapiens	66-75
8450071-7	1993	IFN gamma-activated monocytes incorporated 33% less iron from 59Fe-transferrin than nonactivated monocytes (P &lt; 0.05, t test).	Iron	52-56	interferon gamma	Homo sapiens	0-9
8450071-7	1993	IFN gamma-activated monocytes incorporated 33% less iron from 59Fe-transferrin than nonactivated monocytes (P &lt; 0.05, t test).	Iron	52-56	transferrin	Homo sapiens	67-78
8450071-8	1993	Gel filtration chromatography revealed that incorporated iron is located primarily in ferritin in both nonactivated and IFN gamma-activated monocytes.	Iron	57-61	interferon gamma	Homo sapiens	120-129
8450071-11	1993	We have found that iron transferrin markedly upregulates both transferrin receptor expression and intracellular ferritin content in both nonactivated (2.3- and 1.3-fold, respectively) and IFN gamma-activated (3.4- and 2.9-fold, respectively) monocytes.	Iron	19-23	transferrin	Homo sapiens	24-35
8450071-11	1993	We have found that iron transferrin markedly upregulates both transferrin receptor expression and intracellular ferritin content in both nonactivated (2.3- and 1.3-fold, respectively) and IFN gamma-activated (3.4- and 2.9-fold, respectively) monocytes.	Iron	19-23	transferrin	Homo sapiens	62-73
8450071-11	1993	We have found that iron transferrin markedly upregulates both transferrin receptor expression and intracellular ferritin content in both nonactivated (2.3- and 1.3-fold, respectively) and IFN gamma-activated (3.4- and 2.9-fold, respectively) monocytes.	Iron	19-23	interferon gamma	Homo sapiens	188-197
8450071-12	1993	This study demonstrates that transferrin receptor expression and intracellular ferritin content in human monocytes is unidirectionally and coordinately upregulated by iron transferrin and unidirectionally and coordinately downregulated by IFN gamma.	Iron	167-171	transferrin	Homo sapiens	29-40
8450071-12	1993	This study demonstrates that transferrin receptor expression and intracellular ferritin content in human monocytes is unidirectionally and coordinately upregulated by iron transferrin and unidirectionally and coordinately downregulated by IFN gamma.	Iron	167-171	transferrin	Homo sapiens	172-183
8446581-0	1993	A small single-"finger" peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex.	Iron	118-122	GATA binding protein 1	Homo sapiens	72-78
8387476-4	1993	Increased hepatic iron is normally associated with decreased serum transferrin and total iron binding capacity in hepatic iron overload.	Iron	18-22	transferrin	Rattus norvegicus	67-78
8387476-5	1993	In LEC rats, however, both serum transferrin and total iron binding capacity increased with increasing hepatic iron.	Iron	111-115	transferrin	Rattus norvegicus	33-44
8428002-0	1993	Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects.	Iron	80-84	erythropoietin	Homo sapiens	64-78
8505377-11	1993	The evidence supports an iron transport model in which iron-loaded transferrin is taken up by receptor-mediated endocytosis at the luminal membrane of brain capillaries.	Iron	25-29	transferrin	Rattus norvegicus	67-78
8427873-4	1993	The iron-binding properties of transferrin and the iron-oxidising properties of caeruloplasmin, at a reaction dilution of 1:50, offer considerable protection against organic and inorganic oxygen radicals generated by iron and ascorbate.	Iron	4-8	transferrin	Homo sapiens	31-42
8428931-0	1993	Iron content of human 5-lipoxygenase, effects of mutations regarding conserved histidine residues.	Iron	0-4	arachidonate 5-lipoxygenase	Homo sapiens	22-36
8428931-10	1993	We conclude that histidines 372 and 550 constitute two of the iron ligands in 5-lipoxygenase.	Iron	62-66	arachidonate 5-lipoxygenase	Homo sapiens	78-92
8444319-0	1993	Non-transferrin-bound-iron in serum and low-molecular-weight-iron in the liver of dietary iron-loaded rats.	Iron	22-26	transferrin	Rattus norvegicus	4-15
8444319-4	1993	High concentrations of an iron-rich ferritin (up to 250 mg/l) were detected in serum of heavily iron-loaded rats forming a large fraction of non-transferrin-bound-iron (5000 micrograms/dl in maximum).	Iron	26-30	transferrin	Rattus norvegicus	145-156
8505377-12	1993	The iron then dissociates from transferrin in endosomal compartments and is transcytosed by unknown mechanisms, while the transferrin is retroendocytosed.	Iron	4-8	transferrin	Rattus norvegicus	31-42
8444218-3	1993	Lymphocytes of iron-deficient children produced less interleukin-2 in vitro.	Iron	15-19	interleukin 2	Homo sapiens	53-66
8444218-4	1993	Iron supplementation for 2 months increased mean corpuscular volume, serum ferritin and serum transferrin, but had no effect on the parameters of T-cell mediated immunity.	Iron	0-4	transferrin	Homo sapiens	94-105
8444218-5	1993	The lower interleukin-2 levels in iron-deficient suggest that cell-mediated immunity may be impaired in iron deficiency.	Iron	34-38	interleukin 2	Homo sapiens	10-23
8505377-11	1993	The evidence supports an iron transport model in which iron-loaded transferrin is taken up by receptor-mediated endocytosis at the luminal membrane of brain capillaries.	Iron	55-59	transferrin	Rattus norvegicus	67-78
8474687-1	1993	Haemopexin is a 60 kDa serum glycoprotein responsible for the transport of haem to tissues such as liver, by receptor-mediated endocytosis, in an analogous manner to the iron transport protein transferrin, with recycling of intact haemopexin.	Iron	170-174	transferrin	Homo sapiens	193-204
8384244-2	1993	At physiological pH transferrin firmly binds two ruthenium(III) equivalents at the same sites of iron(III).	Iron	97-101	transferrin	Homo sapiens	20-31
7677965-10	1993	CONCLUSIONS: Intravenous recombinant erythropoietin with iron supplementation alternating with hydroxyurea elevates fetal-hemoglobin and F-cell levels more than hydroxyurea alone.	Iron	57-61	erythropoietin	Homo sapiens	37-51
8191729-3	1993	The intensity of Fe-transferrin electron paramagnetic resonance was statistically reduced, that may be related to reduction of trivalent iron to bivalent and formation of a pool of free bivalent iron--a potent inductor of lipid peroxidation.	Iron	137-141	transferrin	Homo sapiens	20-31
8191729-3	1993	The intensity of Fe-transferrin electron paramagnetic resonance was statistically reduced, that may be related to reduction of trivalent iron to bivalent and formation of a pool of free bivalent iron--a potent inductor of lipid peroxidation.	Iron	195-199	transferrin	Homo sapiens	20-31
8430103-0	1993	sid1, a gene initiating siderophore biosynthesis in Ustilago maydis: molecular characterization, regulation by iron, and role in phytopathogenicity.	Iron	111-115	sister of indeterminate spikelet 1	Zea mays	0-4
8443348-4	1993	A precursor/product relationship between iron stored in ferritin and iron in nitrogenase or leghemoglobin is suggested.	Iron	41-45	leghemoglobin A	Glycine max	92-105
8435091-6	1993	After intestinal absorption, TMH-ferrocene iron in the portal blood is transported to the liver independently from transferrin.	Iron	43-47	transferrin	Rattus norvegicus	115-126
8380064-2	1993	Cell surface transferrin binding and iron uptake from transferrin each decreased by about 50% in stable transfectants bearing integrated antisense DNA expression vector.	Iron	37-41	transferrin	Homo sapiens	54-65
8503244-0	1993	Iron chelators may enhance erythropoiesis by increasing iron delivery to haematopoietic tissue and erythropoietin response in iron-loading anaemia.	Iron	0-4	erythropoietin	Homo sapiens	99-113
8503244-0	1993	Iron chelators may enhance erythropoiesis by increasing iron delivery to haematopoietic tissue and erythropoietin response in iron-loading anaemia.	Iron	126-130	erythropoietin	Homo sapiens	99-113
8503244-4	1993	In addition, a reduction of iron stores may upregulate erythropoietin response and bring about a decrease of disease activity in inflammatory disorders, resulting in a haemoglobin rise.	Iron	28-32	erythropoietin	Homo sapiens	55-69
8111336-2	1993	Iron transport in plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor.	Iron	0-4	transferrin	Homo sapiens	43-54
8117850-0	1993	Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free radicals and prevents methemoglobin formation and iron release.	Iron	134-138	superoxide dismutase 1	Homo sapiens	24-44
8117850-0	1993	Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free radicals and prevents methemoglobin formation and iron release.	Iron	134-138	catalase	Homo sapiens	45-53
8117850-12	1993	Furthermore, the amount of iron released, after incubation with 250 microM H2O2, was 6.8 +/- 1.8 micrograms/dl for PolyHb-SOD-catalase and 76.6 +/- 1.0 micrograms/dl for PolyHb.	Iron	27-31	superoxide dismutase 1	Homo sapiens	122-125
8117850-12	1993	Furthermore, the amount of iron released, after incubation with 250 microM H2O2, was 6.8 +/- 1.8 micrograms/dl for PolyHb-SOD-catalase and 76.6 +/- 1.0 micrograms/dl for PolyHb.	Iron	27-31	catalase	Homo sapiens	126-134
8430794-0	1993	Lactoferrin interferes with uptake of iron from transferrin and asialotransferrin by the rat liver.	Iron	38-42	transferrin	Rattus norvegicus	48-59
8430794-3	1993	At this dose level, iron uptake from transferrin was reduced by 28% and from asialotransferrin by 43% in experiments lasting 90 min.	Iron	20-24	transferrin	Rattus norvegicus	37-48
8430794-9	1993	The data obtained are compatible with the hypothesis that lactoferrin and other proteins with similarly high affinity for hepatic heparan sulfate exert their negative effect on iron uptake by preventing transferrin binding to the proteoglycan.	Iron	177-181	transferrin	Rattus norvegicus	203-214
8476268-1	1993	The transferrin receptor plays a critical role in iron metabolism by precisely controlling the flow of transferrin iron into body cells.	Iron	50-54	transferrin	Homo sapiens	4-15
8476268-1	1993	The transferrin receptor plays a critical role in iron metabolism by precisely controlling the flow of transferrin iron into body cells.	Iron	115-119	transferrin	Homo sapiens	4-15
7681683-1	1993	Iron (Fe) absorption by three segments (duodenum, jejunum, and ileum) of the small intestine of chickens was studied by a perfusion technique in vivo in closed circuit using 59Fe Cl3 and was related to the histological characteristics of each segment.	Iron	0-4	collectin subfamily member 12	Gallus gallus	179-182
8111336-2	1993	Iron transport in plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor.	Iron	70-74	transferrin	Homo sapiens	43-54
8439591-9	1993	However, iron uptake of HPS cultured HL-60 cells, after incubation with saturated human transferrin, was higher, resulting in a higher concentration of iron in HPS cultured HL-60 cells as compared with FBS cultured cells (1.72 +/- 0.02 mumol/g protein v. 1.32 +/- 0.14 mumol/g protein; P &lt; 0.001).	Iron	9-13	transferrin	Homo sapiens	88-99
8439591-9	1993	However, iron uptake of HPS cultured HL-60 cells, after incubation with saturated human transferrin, was higher, resulting in a higher concentration of iron in HPS cultured HL-60 cells as compared with FBS cultured cells (1.72 +/- 0.02 mumol/g protein v. 1.32 +/- 0.14 mumol/g protein; P &lt; 0.001).	Iron	152-156	transferrin	Homo sapiens	88-99
8485201-1	1993	Transferrin receptor (TfR) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin, the major iron-carrier protein.	Iron	77-81	transferrin	Homo sapiens	124-135
8485201-1	1993	Transferrin receptor (TfR) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin, the major iron-carrier protein.	Iron	147-151	transferrin	Homo sapiens	124-135
8375432-2	1993	Iron-dependent microsomal lipid peroxidation could be initiated by reduced irons coordinated with phosphate moieties in the membranes and significantly inhibited by copper salicylate (hydrophobic and permeable O2-scavenger) and desferrioxamine (a powerful iron-chelating agent), but not by SOD.	Iron	0-4	superoxide dismutase 1	Homo sapiens	290-293
7764128-6	1993	Efficient iron supply is mediated through the inclusion of the compound Aurintricarboxylic acid as a synthetic replacement for transferrin.	Iron	10-14	transferrin	Homo sapiens	127-138
8346713-3	1993	The present study was carried out to investigate the effect of low-dose IL-2 subcutaneous immunotherapy (3 million IU/day for 6 days/week for 4 weeks) on ferritin, transferring and iron serum levels in cancer patients.	Iron	181-185	interleukin 2	Homo sapiens	72-76
8365853-7	1993	These results demonstrate that recombinant human erythropoietin is effective, can eliminate the need for transfusions with risks of immunologic sensitization, infection and iron overload, and can restore the haematocrit to normal levels in many patients with anaemia of end-stage renal disease.	Iron	173-177	erythropoietin	Homo sapiens	49-63
8346713-6	1993	Iron mean levels increased in response to IL-2, without, however, significant differences in respect to the pretreatment concentrations.	Iron	0-4	interleukin 2	Homo sapiens	42-46
8346713-7	1993	These preliminary data, by showing changes in ferritin, transferrin and iron in cancer patients during the immunotherapy with IL-2, would suggest the existence of a cytokine regulation of iron transfer from tissues to blood, perhaps by modulating the macrophage function.	Iron	72-76	interleukin 2	Homo sapiens	126-130
8346713-7	1993	These preliminary data, by showing changes in ferritin, transferrin and iron in cancer patients during the immunotherapy with IL-2, would suggest the existence of a cytokine regulation of iron transfer from tissues to blood, perhaps by modulating the macrophage function.	Iron	188-192	transferrin	Homo sapiens	56-67
8346713-7	1993	These preliminary data, by showing changes in ferritin, transferrin and iron in cancer patients during the immunotherapy with IL-2, would suggest the existence of a cytokine regulation of iron transfer from tissues to blood, perhaps by modulating the macrophage function.	Iron	188-192	interleukin 2	Homo sapiens	126-130
8413773-6	1993	In phase 1, we found that the lower basal serum iron and iron transferrin saturation the greater serum aluminum (p &lt; 0.001).	Iron	57-61	transferrin	Homo sapiens	62-73
8383784-11	1993	Transferrin binds with high affinity to SCLC cells and stimulates iron transport and growth.	Iron	66-70	transferrin	Homo sapiens	0-11
8255518-0	1993	Monitoring of iron requirements in renal patients on erythropoietin.	Iron	14-18	erythropoietin	Homo sapiens	53-67
8413773-8	1993	These results suggest that the amount of either aluminum or iron carried by transferrin may influence the transferrin capacity to bind the other element and also may modulate, together with other factors, the gastrointestinal absorption of iron and aluminum.	Iron	60-64	transferrin	Homo sapiens	76-87
8413773-8	1993	These results suggest that the amount of either aluminum or iron carried by transferrin may influence the transferrin capacity to bind the other element and also may modulate, together with other factors, the gastrointestinal absorption of iron and aluminum.	Iron	60-64	transferrin	Homo sapiens	106-117
8413773-8	1993	These results suggest that the amount of either aluminum or iron carried by transferrin may influence the transferrin capacity to bind the other element and also may modulate, together with other factors, the gastrointestinal absorption of iron and aluminum.	Iron	240-244	transferrin	Homo sapiens	76-87
8378849-5	1993	Iron preparation as a corrective treatment contributed to hematocrit increment reducing effective doses of erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	107-121
8448418-13	1993	Cytochrome P-450 levels and the in vitro formation of benzo[a]pyrene-DNA adducts were higher in Low Iron-Low Iron males than in Control males.	Iron	100-104	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
8448418-13	1993	Cytochrome P-450 levels and the in vitro formation of benzo[a]pyrene-DNA adducts were higher in Low Iron-Low Iron males than in Control males.	Iron	109-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
8448418-15	1993	These results show that the iron deficiency-induced alterations were transient, reversible with iron repletion, and in the case of cytochrome P-450 and ethoxycoumarin O-deethylase activity, dependent on the age and sex of the animal.	Iron	28-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-179
8327847-2	1993	The receptor participates in the cellular acquisition of iron from transferrin by receptor-mediated endocytosis.	Iron	57-61	transferrin	Homo sapiens	67-78
8327847-5	1993	In the assessment of body iron status and erythropoietic activity the measurement of circulating transferrin receptor has proved to be of value as a measure of mild tissue iron deficiency, to distinguish iron deficiency anemia from the anemias of chronic disease, and as a sensitive index of iron deficiency during pregnancy.	Iron	26-30	transferrin	Homo sapiens	97-108
1337663-1	1992	Gallium, when bound to transferrin, has been previously shown to cause tumor cell cytotoxicity by preventing cellular uptake of transferrin bound iron in vitro.	Iron	146-150	transferrin	Homo sapiens	23-34
20732171-3	1993	One day after iron treatment, significant increases in aspartate aminotransferase and lactate dehydrogenase in the culture medium were measured; under similar conditions, albumin and transferrin secretions were decreased.	Iron	14-18	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	55-81
20732171-3	1993	One day after iron treatment, significant increases in aspartate aminotransferase and lactate dehydrogenase in the culture medium were measured; under similar conditions, albumin and transferrin secretions were decreased.	Iron	14-18	transferrin	Rattus norvegicus	183-194
1335284-11	1992	Hypotransferrinaemic mouse serum therefore contains large quantities of non-transferrin-bound iron which is unreactive in some assays used to detect such iron in human iron overload.	Iron	94-98	transferrin	Homo sapiens	4-15
1288287-9	1992	Reduced EPO secretion thus seems to play a role in the progression of unexplained senile anemia, and recombinant human EPO may possibly be effective for treating this type of anemia by mobilizing excess iron.	Iron	203-207	erythropoietin	Homo sapiens	119-122
1447194-1	1992	The iron-responsive element binding protein (IRE-BP) interacts with specific sequence/structure motifs (iron-responsive elements) within the mRNAs encoding ferritin and the transferrin receptor and thereby post-transcriptionally regulates the expression of these two proteins involved in cellular iron homeostasis.	Iron	4-8	transferrin	Homo sapiens	173-184
1447194-1	1992	The iron-responsive element binding protein (IRE-BP) interacts with specific sequence/structure motifs (iron-responsive elements) within the mRNAs encoding ferritin and the transferrin receptor and thereby post-transcriptionally regulates the expression of these two proteins involved in cellular iron homeostasis.	Iron	104-108	transferrin	Homo sapiens	173-184
1337663-1	1992	Gallium, when bound to transferrin, has been previously shown to cause tumor cell cytotoxicity by preventing cellular uptake of transferrin bound iron in vitro.	Iron	146-150	transferrin	Homo sapiens	128-139
1337663-4	1992	Atomic analysis of iron and gallium content of Sephadex G-150 fractions of treatment sera indicate that about an equimolar amount of gallium and iron are associated with transferrin.	Iron	145-149	transferrin	Homo sapiens	170-181
1337663-5	1992	These gallium and iron concentrations result in inhibition of transferrin mediated iron uptake in vitro, and in vivo allow for &gt; 90% saturation of transferrin with metal.	Iron	18-22	transferrin	Homo sapiens	62-73
1337663-5	1992	These gallium and iron concentrations result in inhibition of transferrin mediated iron uptake in vitro, and in vivo allow for &gt; 90% saturation of transferrin with metal.	Iron	18-22	transferrin	Homo sapiens	150-161
1337663-5	1992	These gallium and iron concentrations result in inhibition of transferrin mediated iron uptake in vitro, and in vivo allow for &gt; 90% saturation of transferrin with metal.	Iron	83-87	transferrin	Homo sapiens	62-73
1457588-0	1992	Iron stores and serum transferrin receptor levels during recombinant human erythropoietin treatment of anemia in rheumatoid arthritis.	Iron	0-4	erythropoietin	Homo sapiens	75-89
1444477-0	1992	Binding of cytosolic aconitase to the iron responsive element of porcine mitochondrial aconitase mRNA.	Iron	38-42	aconitase 2	Homo sapiens	73-96
1444477-1	1992	The 5" end of porcine mitochondrial aconitase mRNA contains an iron responsive element (IRE)-like secondary structure (T. Dandekar, R. Stripecke, N. K. Gray, B. Goosen, A. Constable, H. E. Johansson, and M. W. Hentze (1991) EMBO J.	Iron	63-67	aconitase 2	Homo sapiens	22-45
1334975-9	1992	IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes.	Iron	38-42	interleukin 1 beta	Rattus norvegicus	0-9
1337663-8	1992	Since transferrin receptor increases on gallium treated iron requiring cells in vitro, we assessed cell surface transferrin receptor on peripheral blood lymphocytes by measuring fluorescent transferrin receptor antibody binding.	Iron	56-60	transferrin	Homo sapiens	6-17
1282813-1	1992	The formed complexes of cytochrome c with polyanions retain the bond of Met-80 with heme iron.	Iron	89-93	cytochrome c, somatic	Homo sapiens	24-36
1482396-8	1992	These observation suggest that transferrin receptors in plasma membranes bind diferric transferrin, and, in an undetermined way, facilitate Fe(III) release so that iron reduction can occur.	Iron	164-168	transferrin	Homo sapiens	31-42
1334975-9	1992	IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes.	Iron	136-140	interleukin 1 beta	Rattus norvegicus	0-9
1487730-4	1992	In contrast, no binding inhibition was seen with ferric nitrate, protoporphyrin IX, and iron-loaded human transferrin.	Iron	88-92	transferrin	Homo sapiens	106-117
1446663-2	1992	Human 5-lipoxygenase is a non-heme iron protein which is reported to be highly unstable in the presence of oxygen.	Iron	35-39	arachidonate 5-lipoxygenase	Homo sapiens	6-20
1298075-1	1992	Iron status of pregnant women at different stages of pregnancy was evaluated by comparing values for hemoglobin (Hb), red cell indices, serum iron (SI), transferrin saturation (TS) and serum ferritin (SF) values with those of a group of non-pregnant women of comparable age and socio-economic status.	Iron	0-4	transferrin	Homo sapiens	153-164
1475793-6	1992	Under the same experimental conditions, microsomal cytochrome P-450 content was decreased by 40%, 2 h after iron treatment.	Iron	108-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	51-67
1475793-9	1992	Catalase and superoxide dismutase activities declined by 25 and 36%, respectively, compared with control values 4 h after the iron dose.	Iron	126-130	catalase	Homo sapiens	0-8
1334504-1	1992	Choroid plexus epithelial cells are enriched in mRNA for proteins such as the iron carrier transferrin, which acts as a trophic factor in the brain.	Iron	78-82	transferrin	Rattus norvegicus	91-102
1464734-5	1992	IFN-treated RAW 264.7 cells also had significantly decreased levels of intracellular iron (below assay limit) when compared to IFN+NGMMA-treated cells (72.0 +/- 0.78% of control).	Iron	85-89	interferon alpha 1	Homo sapiens	0-3
1446663-5	1992	Purification of 5-lipoxygenase under aerobic conditions (no dithiothreitol) results in an increase in both the specific activity of the purified protein [up to 70 mumol 5(S)-hydroperoxy-6-trans-8, 11, 14-cis-icosatetraenoic acid (5-HPETE)/mg protein] and in the ratio of specific activity to enzyme iron content compared to enzyme purified under anaerobic conditions in the presence of dithiothreitol.	Iron	299-303	arachidonate 5-lipoxygenase	Homo sapiens	16-30
1415012-2	1992	Increasing dietary iron intake, by consuming more nonheme iron in the diet, had questionable effects on hematological status (hematocrit values and ferritin and transferrin concentrations) and negative effects on nutritional status in regard to manganese (serum manganese, urine manganese, and lymphocyte manganese-dependent superoxide dismutase activity).	Iron	19-23	transferrin	Homo sapiens	161-172
1332689-0	1992	Investigation of the electron-transfer properties of cytochrome c oxidase covalently cross-linked to Fe- or Zn-containing cytochrome c.	Iron	101-103	cytochrome c, somatic	Homo sapiens	53-65
1332689-0	1992	Investigation of the electron-transfer properties of cytochrome c oxidase covalently cross-linked to Fe- or Zn-containing cytochrome c.	Iron	101-103	cytochrome c, somatic	Homo sapiens	122-134
1332689-1	1992	Complexes of cytochrome c oxidase and cytochrome c (Fe- or Zn-containing) have been prepared by 1-ethyl-3-[3-(dimethylamino)propyl]carbodi-imide (EDC) cross-linking.	Iron	52-54	cytochrome c, somatic	Homo sapiens	13-25
1332689-1	1992	Complexes of cytochrome c oxidase and cytochrome c (Fe- or Zn-containing) have been prepared by 1-ethyl-3-[3-(dimethylamino)propyl]carbodi-imide (EDC) cross-linking.	Iron	52-54	cytochrome c, somatic	Homo sapiens	38-50
1332689-3	1992	Stopped-flow experiments, monitored either at a single wavelength or through a rapid wavelength-scan facility, showed that covalently bound Fe-containing cytochrome c cannot donate electrons to cytochrome a.	Iron	140-142	cytochrome c, somatic	Homo sapiens	154-166
1332689-4	1992	Free Fe-containing cytochrome c was, however, able to transfer electrons to cytochrome a in covalent complexes containing either Fe- or Zn-containing cytochrome c.	Iron	5-7	cytochrome c, somatic	Homo sapiens	19-31
1332689-4	1992	Free Fe-containing cytochrome c was, however, able to transfer electrons to cytochrome a in covalent complexes containing either Fe- or Zn-containing cytochrome c.	Iron	5-7	cytochrome c, somatic	Homo sapiens	150-162
1332689-4	1992	Free Fe-containing cytochrome c was, however, able to transfer electrons to cytochrome a in covalent complexes containing either Fe- or Zn-containing cytochrome c.	Iron	129-131	cytochrome c, somatic	Homo sapiens	19-31
1426763-1	1992	Transferrin (Tf) is the iron-transport protein of vertebrate serum.	Iron	24-28	transferrin	Homo sapiens	0-11
1426763-1	1992	Transferrin (Tf) is the iron-transport protein of vertebrate serum.	Iron	24-28	transferrin	Homo sapiens	13-15
1296812-1	1992	Transferrin, the major iron-binding protein in the plasma of vertebrate species, is an essential growth factor for proliferating malignant cells.	Iron	23-27	transferrin	Homo sapiens	0-11
1415188-6	1992	This feature may be considered as an ultrastructural marker of iron deficiency and is consistent with the present knowledge on transferrin-mediated delivery of iron to the cell.	Iron	63-67	transferrin	Homo sapiens	127-138
1487613-3	1992	Serum iron levels and transferrin iron saturation increased and remained elevated 4 years after surgery.	Iron	34-38	transferrin	Homo sapiens	22-33
1431504-3	1992	The subcutaneous administration of 100 U recombinant human erythropoietin/kg body weight given on 10 successive days over a 2-week period induced a brisk increase in erythropoiesis and a sharp decrease in iron stores.	Iron	205-209	erythropoietin	Homo sapiens	59-73
1327159-4	1992	The iron-binding properties of transferrin and the iron-oxidising properties of caeruloplasmin, at a reaction dilution of 1:50, offer considerable protection against organic and inorganic oxygen radicals generated by iron and ascorbate.	Iron	4-8	transferrin	Homo sapiens	31-42
1431504-8	1992	It is concluded that the striking enhancement of iron absorption following regular erythropoietin administration in normal subjects is related to the combined effect of diminished iron stores and augmented erythropoiesis.	Iron	49-53	erythropoietin	Homo sapiens	83-97
1431504-8	1992	It is concluded that the striking enhancement of iron absorption following regular erythropoietin administration in normal subjects is related to the combined effect of diminished iron stores and augmented erythropoiesis.	Iron	180-184	erythropoietin	Homo sapiens	83-97
1420321-0	1992	Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis.	Iron	16-20	transferrin	Homo sapiens	96-107
1420321-1	1992	Iron distribution in subcellular fractions was investigated at different times after a single cohort of 59Fe-125 I-labeled transferrin (Tf) endocytosis in K562 cells.	Iron	0-4	transferrin	Homo sapiens	123-134
1400450-0	1992	Intermediate steps in cellular iron uptake from transferrin.	Iron	31-35	transferrin	Homo sapiens	48-59
1400450-2	1992	The uptake of transferrin-bound iron by receptor-mediated endocytosis has been the subject of extensive experimental investigation.	Iron	32-36	transferrin	Homo sapiens	14-25
1400450-3	1992	However, the path followed by iron (Fe) after release from transferrin (Tf) remains obscure.	Iron	36-38	transferrin	Homo sapiens	59-70
1400450-5	1992	The present investigation describes the presence of a cytoplasmic Tf-free Fe pool which is detectable only when cells are detached from their culture dishes at low temperature, after initial incorporation of diferric transferrin at 37 degrees C. This cellular iron pool was greatly reduced if incubation temperatures were maintained at 37 degrees C or if cells were treated with pronase.	Iron	74-76	transferrin	Homo sapiens	217-228
1400450-5	1992	The present investigation describes the presence of a cytoplasmic Tf-free Fe pool which is detectable only when cells are detached from their culture dishes at low temperature, after initial incorporation of diferric transferrin at 37 degrees C. This cellular iron pool was greatly reduced if incubation temperatures were maintained at 37 degrees C or if cells were treated with pronase.	Iron	260-264	transferrin	Homo sapiens	217-228
1450923-4	1992	Iron and transferrin uptake into the brain and CSF decreased with increasing age and was greater in the iron-deficient than in the control 21-day rats.	Iron	104-108	transferrin	Rattus norvegicus	9-20
1450923-5	1992	The quantity of 125I-transferrin recovered in the CSF could account for only a small proportion of the iron taken up by the brain.	Iron	103-107	transferrin	Rattus norvegicus	21-32
1450923-8	1992	It is concluded that iron uptake by the brain is dependent on iron release from transferrin at the cerebral capillary endothelial cells with recycling of transferrin to the plasma and transfer of the iron into the brain interstitium.	Iron	21-25	transferrin	Rattus norvegicus	80-91
1415186-4	1992	Total ALAS activity was also increased two- or threefold, perhaps reflecting increased transcription of the housekeeping gene in response to diminished cellular heme in erythroid cells and/or enhanced translation of the erythroid isoform in response to iron accumulation.	Iron	253-257	5'-aminolevulinate synthase 1	Homo sapiens	6-10
1450923-8	1992	It is concluded that iron uptake by the brain is dependent on iron release from transferrin at the cerebral capillary endothelial cells with recycling of transferrin to the plasma and transfer of the iron into the brain interstitium.	Iron	21-25	transferrin	Rattus norvegicus	154-165
1384359-6	1992	It is suggested that iron presented to the tubule fluid as a result of the glomerular leak for transferrin is dissociated from transferrin.	Iron	21-25	transferrin	Rattus norvegicus	95-106
1450923-8	1992	It is concluded that iron uptake by the brain is dependent on iron release from transferrin at the cerebral capillary endothelial cells with recycling of transferrin to the plasma and transfer of the iron into the brain interstitium.	Iron	62-66	transferrin	Rattus norvegicus	80-91
1450923-8	1992	It is concluded that iron uptake by the brain is dependent on iron release from transferrin at the cerebral capillary endothelial cells with recycling of transferrin to the plasma and transfer of the iron into the brain interstitium.	Iron	62-66	transferrin	Rattus norvegicus	80-91
1415806-0	1992	Iron uptake in relation to transferrin degradation in brain and other tissues of rats.	Iron	0-4	transferrin	Rattus norvegicus	27-38
1415806-1	1992	The possibility that iron uptake by the brain involves transcytosis of the iron-transferrin complex across the brain capillaries, followed by degradation of the transferrin (Tf) within the brain, was investigated using diferric 125I-[59Fe]Tf and [59Fe]Tf coupled to 125I-tyramine cellobiose (TC).	Iron	21-25	transferrin	Rattus norvegicus	80-91
1415806-1	1992	The possibility that iron uptake by the brain involves transcytosis of the iron-transferrin complex across the brain capillaries, followed by degradation of the transferrin (Tf) within the brain, was investigated using diferric 125I-[59Fe]Tf and [59Fe]Tf coupled to 125I-tyramine cellobiose (TC).	Iron	21-25	transferrin	Rattus norvegicus	161-172
1415806-1	1992	The possibility that iron uptake by the brain involves transcytosis of the iron-transferrin complex across the brain capillaries, followed by degradation of the transferrin (Tf) within the brain, was investigated using diferric 125I-[59Fe]Tf and [59Fe]Tf coupled to 125I-tyramine cellobiose (TC).	Iron	75-79	transferrin	Rattus norvegicus	80-91
1384465-14	1992	These results also suggest that nitric oxide mediates IL-1 beta-induced inhibitory effects on the pancreatic beta-cell by functioning as an effector molecule responsible for the destruction of iron-sulphur centres of iron-containing proteins, resulting in an impairment of mitochondrial function.	Iron	193-197	interleukin 1 beta	Homo sapiens	54-63
1524418-7	1992	Oxidation of 1,2-propanediol to formaldehyde plus acetaldehyde involved interaction with an oxidant derived from H2O2 plus nonheme iron, since production of the two aldehydic products was completely prevented by catalase or glutathione plus glutathione peroxidase and by chelators such as desferrioxamine or EDTA.	Iron	131-135	catalase	Rattus norvegicus	212-220
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Iron	71-75	interleukin 1 beta	Homo sapiens	14-23
1466649-5	1992	By comparison with controls, in iron-injected animals, we found significant increases of: (1) serum total iron (by 110%); (2) aggregation of isolated platelets induced by low concentration of thrombin and ADP (by 350% and 120%, respectively); (3) thrombin-induced endogenous serotonin secretion (by 94%).	Iron	32-36	coagulation factor II	Rattus norvegicus	192-200
1466649-5	1992	By comparison with controls, in iron-injected animals, we found significant increases of: (1) serum total iron (by 110%); (2) aggregation of isolated platelets induced by low concentration of thrombin and ADP (by 350% and 120%, respectively); (3) thrombin-induced endogenous serotonin secretion (by 94%).	Iron	32-36	coagulation factor II	Rattus norvegicus	247-255
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Iron	71-75	interleukin 1 beta	Homo sapiens	195-204
1384465-14	1992	These results also suggest that nitric oxide mediates IL-1 beta-induced inhibitory effects on the pancreatic beta-cell by functioning as an effector molecule responsible for the destruction of iron-sulphur centres of iron-containing proteins, resulting in an impairment of mitochondrial function.	Iron	217-221	interleukin 1 beta	Homo sapiens	54-63
1384465-9	1992	Iron-nitrosyl complex-formation by islets confirms that IL-1 beta induces the generation of nitric oxide by islets, and provides evidence indicating that nitric oxide mediates destruction of iron-sulphur clusters of iron-containing enzymes.	Iron	191-195	interleukin 1 beta	Homo sapiens	56-65
1419825-0	1992	Serum non-transferrin-bound iron in beta-thalassaemia major patients treated with desferrioxamine and L1.	Iron	28-32	transferrin	Homo sapiens	10-21
1384465-9	1992	Iron-nitrosyl complex-formation by islets confirms that IL-1 beta induces the generation of nitric oxide by islets, and provides evidence indicating that nitric oxide mediates destruction of iron-sulphur clusters of iron-containing enzymes.	Iron	216-220	interleukin 1 beta	Homo sapiens	56-65
1419825-1	1992	Non-transferrin-bound iron (NTBI) in plasma is toxic due to its ability to participate in free radical formation with resultant peroxidation and damage to cell membranes and other biomolecules.	Iron	22-26	transferrin	Homo sapiens	4-15
1384624-1	1992	The role of transferrin in iron metabolism is evaluated, both with regard to iron uptake by transferrin and to iron uptake from transferrin by different cells.	Iron	27-31	transferrin	Homo sapiens	12-23
1419827-5	1992	Further reduction in iron stores through repeated phlebotomy whilst the increase in haemoglobin was maintained by treatment with erythropoietin, tended to increase whole body retention of iron through an increase in mucosal transfer (P = 0.010).	Iron	188-192	erythropoietin	Homo sapiens	129-143
1419828-1	1992	The uptake of transferrin by macrophages was studied in relation to the degree of iron saturation.	Iron	82-86	transferrin	Rattus norvegicus	14-25
1384627-0	1992	The effect of different iron compounds on transferrin receptor expression in term human cytotrophoblast cells.	Iron	24-28	transferrin	Homo sapiens	42-53
1384627-11	1992	Fe is transported to the placenta by transferrin.	Iron	0-2	transferrin	Homo sapiens	37-48
1384627-13	1992	During this cycle, Fe is released from transferrin and the transferrin-transferrin receptor complex is recycled to the membrane.	Iron	19-21	transferrin	Homo sapiens	39-50
1384627-13	1992	During this cycle, Fe is released from transferrin and the transferrin-transferrin receptor complex is recycled to the membrane.	Iron	19-21	transferrin	Homo sapiens	59-70
1384627-13	1992	During this cycle, Fe is released from transferrin and the transferrin-transferrin receptor complex is recycled to the membrane.	Iron	19-21	transferrin	Homo sapiens	59-70
1384627-16	1992	By regulation of the number of transferrin receptors, trophoblasts are able to control their Fe uptake.	Iron	93-95	transferrin	Homo sapiens	31-42
1327776-6	1992	D. desulfuricans ATCC 7757 hydrogenase was free of nickel and contained 14.0 atoms of iron and 14.4 atoms of acid-labile sulfur/molecule and had E400, 52.5 mM-1.cm-1.	Iron	86-90	DVU2400	Desulfovibrio vulgaris str. Hildenborough	27-38
1394993-0	1992	Transferrin index: an alternative method for calculating the iron saturation of transferrin.	Iron	61-65	transferrin	Homo sapiens	0-11
1394993-0	1992	Transferrin index: an alternative method for calculating the iron saturation of transferrin.	Iron	61-65	transferrin	Homo sapiens	80-91
1338510-0	1992	[Effect of placental transferrin receptors on iron nutritional state of normal full-term gravidas and their newborns].	Iron	46-50	transferrin	Homo sapiens	21-32
1398507-0	1992	Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation.	Iron	68-72	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	8-28
1435878-0	1992	A transferrin-independent iron uptake activity in Plasmodium falciparum-infected and uninfected erythrocytes.	Iron	26-30	transferrin	Homo sapiens	2-13
1435878-2	1992	Utilization of iron bound to serum transferrin by the parasitized cells has been postulated, but direct evidence for its specific delivery has not been reported.	Iron	15-19	transferrin	Homo sapiens	35-46
1435878-5	1992	A transferrin-independent non-heme iron uptake activity was, however, detected in both infected and uninfected erythrocytes when iron was presented to the cells as 55Fe-NTA or 55Fe-citrate.	Iron	35-39	transferrin	Homo sapiens	2-13
1435878-5	1992	A transferrin-independent non-heme iron uptake activity was, however, detected in both infected and uninfected erythrocytes when iron was presented to the cells as 55Fe-NTA or 55Fe-citrate.	Iron	129-133	transferrin	Homo sapiens	2-13
1435878-7	1992	Evidence is presented that the transferrin-independent iron uptake activity is time-, temperature- and concentration-dependent, but apparently not energy-dependent.	Iron	55-59	transferrin	Homo sapiens	31-42
1338510-7	1992	The differences of dissociate constant (Kd) of transferrin receptor were not significant among the four groups, indicating that the iron metabolism between mothers and their babies was regulated not by changing the affinity of transferrin binding to its receptor but by changing the numbers of transferrin receptor to maintain the relative stableness of newborns iron nutritional state.	Iron	132-136	transferrin	Homo sapiens	47-58
1527028-3	1992	A component of this regulatory system is the ferritin repressor protein (FRP) which binds to the iron-responsive element (IRE) located at the 5" end of all known ferritin mRNAs, thus inhibiting its translation.	Iron	97-101	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	73-76
1326522-5	1992	This indicates that the photo-dissociated NO can move far away from the heme iron in the less restricted distal heme moiety of the substrate-free cytochrome P450scc.	Iron	77-81	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	146-164
1382606-5	1992	Transferrin levels and serum iron levels in aging humans also diminish, as observed from measurements of total iron binding capacity and percent iron saturation in sera from 701 individuals ranging from 0 to 99 years of age.	Iron	111-115	transferrin	Homo sapiens	0-11
1382606-5	1992	Transferrin levels and serum iron levels in aging humans also diminish, as observed from measurements of total iron binding capacity and percent iron saturation in sera from 701 individuals ranging from 0 to 99 years of age.	Iron	111-115	transferrin	Homo sapiens	0-11
1382421-3	1992	Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine.	Iron	112-124	cytochrome c, somatic	Homo sapiens	86-98
1382421-3	1992	Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine.	Iron	129-141	cytochrome c, somatic	Homo sapiens	86-98
1527027-2	1992	The iron-responsive element binding protein (IRE-BP) is a cytosolic protein that binds a highly conserved sequence in the untranslated regions of mRNAs involved in iron metabolism including ferritin, transferrin receptor, and erythroid 5-aminolevulinate acid synthase.	Iron	4-8	transferrin	Rattus norvegicus	200-211
1527027-2	1992	The iron-responsive element binding protein (IRE-BP) is a cytosolic protein that binds a highly conserved sequence in the untranslated regions of mRNAs involved in iron metabolism including ferritin, transferrin receptor, and erythroid 5-aminolevulinate acid synthase.	Iron	164-168	transferrin	Rattus norvegicus	200-211
1526029-0	1992	Effect of pH and citrate on binding of iron and gallium by transferrin in serum.	Iron	39-43	transferrin	Homo sapiens	59-70
1527028-3	1992	A component of this regulatory system is the ferritin repressor protein (FRP) which binds to the iron-responsive element (IRE) located at the 5" end of all known ferritin mRNAs, thus inhibiting its translation.	Iron	97-101	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	45-71
1396927-4	1992	These effects were accompanied by a marked reduction in serum iron concentration and transferrin saturation in patients receiving standard-dose iron supplements, but not in those given larger doses.	Iron	144-148	transferrin	Homo sapiens	85-96
1443573-1	1992	Iron accumulating to excess in tissues of humans and animal models occurs mainly as complexes with transferrin, ferritin, other hemoproteins, and insoluble hemosiderin particles.	Iron	0-4	transferrin	Homo sapiens	99-110
1331338-4	1992	Since iron entry into cells is mediated by the transferrin receptor, this receptor may also serve as marker of neuronal activity.	Iron	6-10	transferrin	Homo sapiens	47-58
1438570-1	1992	We have studied the damage of alcohol dehydrogenase (ADH) and glyceraldehyde 3-phosphate dehydrogenase (GAPD) induced by Fe++/EDTA + H2O2 in combination with UV-A (main output at 365 nm).	Iron	121-125	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	62-102
1438570-1	1992	We have studied the damage of alcohol dehydrogenase (ADH) and glyceraldehyde 3-phosphate dehydrogenase (GAPD) induced by Fe++/EDTA + H2O2 in combination with UV-A (main output at 365 nm).	Iron	121-125	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	104-108
1526029-1	1992	Although both Al and Fe are bound to transferrin in plasma, they are metabolized differently.	Iron	21-23	transferrin	Homo sapiens	37-48
1526029-5	1992	In contrast, almost all Fe remained bound to transferrin at pH values as low as 4.7.	Iron	24-26	transferrin	Homo sapiens	45-56
1324720-9	1992	From these observations it appears that lipoxygenase 1 exists as a pair of tightly associated domains with the iron-binding site located in the larger of the two.	Iron	111-115	seed linoleate 13S-lipoxygenase-1	Glycine max	40-54
1324911-0	1992	Structural investigations by extended X-ray absorption fine structure spectroscopy of the iron center of mitochondrial aconitase in higher plant cells.	Iron	90-94	aconitase 2	Homo sapiens	105-128
1324911-1	1992	We have obtained iron K-edge extended x-ray absorption fine structure spectra of the plant mitochondrial aconitase in its active state, in the presence (aconitase (+)) and absence (aconitase (-)) of the substrate citrate.	Iron	17-21	aconitase 2	Homo sapiens	91-114
1324911-7	1992	These data indicate that active plant mitochondrial aconitase contains a novel type of iron center.	Iron	87-91	aconitase 2	Homo sapiens	38-61
1431877-4	1992	The iron binding sites are similar and the key role of the CO3(2-) anion bound with each Fe3+ can now be understood; structural differences near the iron binding sites suggest reasons for the different binding properties of serum transferrin and lactoferrin.	Iron	4-8	transferrin	Homo sapiens	230-241
1431885-3	1992	In contrast to non-haem iron, the density of transferrin receptors is highest in cortical and brainstem structures and appears to relate to the iron requirement of neurones for mitochondrial respiratory activity.	Iron	144-148	transferrin	Homo sapiens	45-56
1431885-5	1992	The uptake of iron into the brain appears to be by a two-stage process involving initial deposition of iron in the brain capillary endothelium by serum transferrin, and subsequent transfer of iron to brain-derived transferrin and transport within the brain to sites with a high transferrin receptor density.	Iron	14-18	transferrin	Homo sapiens	152-163
1431885-5	1992	The uptake of iron into the brain appears to be by a two-stage process involving initial deposition of iron in the brain capillary endothelium by serum transferrin, and subsequent transfer of iron to brain-derived transferrin and transport within the brain to sites with a high transferrin receptor density.	Iron	14-18	transferrin	Homo sapiens	214-225
1431885-5	1992	The uptake of iron into the brain appears to be by a two-stage process involving initial deposition of iron in the brain capillary endothelium by serum transferrin, and subsequent transfer of iron to brain-derived transferrin and transport within the brain to sites with a high transferrin receptor density.	Iron	14-18	transferrin	Homo sapiens	214-225
1431885-5	1992	The uptake of iron into the brain appears to be by a two-stage process involving initial deposition of iron in the brain capillary endothelium by serum transferrin, and subsequent transfer of iron to brain-derived transferrin and transport within the brain to sites with a high transferrin receptor density.	Iron	103-107	transferrin	Homo sapiens	152-163
1431885-5	1992	The uptake of iron into the brain appears to be by a two-stage process involving initial deposition of iron in the brain capillary endothelium by serum transferrin, and subsequent transfer of iron to brain-derived transferrin and transport within the brain to sites with a high transferrin receptor density.	Iron	103-107	transferrin	Homo sapiens	152-163
1431885-6	1992	A second, as yet unidentified mechanism, may be involved in the transfer of iron from neurones possessing transferrin receptors to sites of storage in glial cells in the extrapyramidal system.	Iron	76-80	transferrin	Homo sapiens	106-117
1431885-7	1992	The distribution of iron and the transferrin receptor may be of relevance to iron-induced free radical formation and selective neuronal vulnerability in neurodegenerative disorders.	Iron	77-81	transferrin	Homo sapiens	33-44
1431877-4	1992	The iron binding sites are similar and the key role of the CO3(2-) anion bound with each Fe3+ can now be understood; structural differences near the iron binding sites suggest reasons for the different binding properties of serum transferrin and lactoferrin.	Iron	149-153	transferrin	Homo sapiens	230-241
1431877-8	1992	The availability of site-specific mutants of both transferrin and lactoferrin now offers the opportunity to probe the structural determinants of iron binding, iron release, and receptor binding.	Iron	145-149	transferrin	Homo sapiens	50-61
1431877-8	1992	The availability of site-specific mutants of both transferrin and lactoferrin now offers the opportunity to probe the structural determinants of iron binding, iron release, and receptor binding.	Iron	159-163	transferrin	Homo sapiens	50-61
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	20-24	aconitase 2	Homo sapiens	36-59
1644834-0	1992	Mutagenesis of the iron-regulatory element further defines a role for RNA secondary structure in the regulation of ferritin and transferrin receptor expression.	Iron	19-23	transferrin	Rattus norvegicus	128-139
1508944-7	1992	Copper supplementation of the cell culture altered the initial rate of iron uptake from transferrin and enhanced iron uptake in noninduced cells; however, in hemin-induced K562 cells, which express fewer transferrin receptors on the cell surface, copper appeared to reduce iron uptake.	Iron	71-75	transferrin	Homo sapiens	88-99
1508944-8	1992	Subsequent studies showed that the cells were able to take up the same amount of iron from transferrin when incubated over a longer period of time (24 hr).	Iron	81-85	transferrin	Homo sapiens	91-102
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	110-114	aconitase 2	Homo sapiens	36-59
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	170-174	aconitase 2	Homo sapiens	36-59
1530145-0	1992	Iron uptake from transferrin and asialotransferrin by hepatocytes from chronically alcohol-fed rats.	Iron	0-4	transferrin	Rattus norvegicus	17-28
1530145-2	1992	As the liver is a major iron storage site and also synthesizes transferrin, the normal serum iron transport protein, the aim of this study was to test the hypothesis that these disturbances in iron homeostasis were caused by altered hepatocyte iron uptake from the abnormal transferrin.	Iron	93-97	transferrin	Rattus norvegicus	63-74
1325116-1	1992	Expression of the rate-limiting heme biosynthetic enzyme 5"-aminolevulinate synthase (ALAS) was investigated in skeletal muscle of 3-wk-old rats fed an iron-deficient diet.	Iron	152-156	5'-aminolevulinate synthase 1	Rattus norvegicus	86-90
1530145-2	1992	As the liver is a major iron storage site and also synthesizes transferrin, the normal serum iron transport protein, the aim of this study was to test the hypothesis that these disturbances in iron homeostasis were caused by altered hepatocyte iron uptake from the abnormal transferrin.	Iron	93-97	transferrin	Rattus norvegicus	63-74
1530145-2	1992	As the liver is a major iron storage site and also synthesizes transferrin, the normal serum iron transport protein, the aim of this study was to test the hypothesis that these disturbances in iron homeostasis were caused by altered hepatocyte iron uptake from the abnormal transferrin.	Iron	93-97	transferrin	Rattus norvegicus	63-74
1530145-3	1992	To achieve this, we have investigated iron uptake from both transferrin and asialotransferrin by hepatocytes from male Sprague-Dawley rats fed the De Carli and Lieber alcohol diet.	Iron	38-42	transferrin	Rattus norvegicus	60-71
1530145-4	1992	Iron uptake from transferrin by hepatocytes from alcoholic rats was less than 60% that of control values, and in the presence of 50 mM ethanol decreased still further to 35% of the uptake by the corresponding control cells.	Iron	0-4	transferrin	Rattus norvegicus	17-28
1530145-5	1992	Iron uptake from rat asialotransferrin was reduced in both groups when compared to that observed from normal transferrin; 13% by control cells and 39% by hepatocytes from alcohol-fed rats.	Iron	0-4	transferrin	Rattus norvegicus	27-38
1413091-4	1992	This review by Rodger McMillan and Ed Walker summarizes the biology of leukotrienes and the current knowledge of the mechanism of 5-lipoxygenase, providing a framework for consideration of the discovery, development and clinical status of drugs in the three major classes of 5-lipoxygenase inhibitors: "redox" inhibitors, iron ligand inhibitors and "non-redox" inhibitors.	Iron	322-326	arachidonate 5-lipoxygenase	Homo sapiens	130-144
1516277-3	1992	MCH and MCV were both found significantly depressed in patients with depleted iron stores, a situation not reflected by any of the other tested parameters.	Iron	78-82	pro-melanin concentrating hormone	Homo sapiens	0-3
1513328-8	1992	According to one proposed mechanism, N-alkylprotoporphyrins inhibit ferrochelatase by serving as transition state analogues for the iron insertion step.	Iron	132-136	ferrochelatase	Rattus norvegicus	68-82
1513328-10	1992	We suggest that this tilting reflects the normal conformational changes required for the insertion of iron into the protoporphyrin IX ring by ferrochelatase and that the greater inhibitory activity of NA and epi-NB isomers, compared with epi-NA and NB isomers, is due to the fact that the normal mechanism for ferrochelatase-catalyzed iron insertion has preference for an A-C ring tilt over a B-D ring tilt.	Iron	102-106	ferrochelatase	Rattus norvegicus	142-156
1513328-10	1992	We suggest that this tilting reflects the normal conformational changes required for the insertion of iron into the protoporphyrin IX ring by ferrochelatase and that the greater inhibitory activity of NA and epi-NB isomers, compared with epi-NA and NB isomers, is due to the fact that the normal mechanism for ferrochelatase-catalyzed iron insertion has preference for an A-C ring tilt over a B-D ring tilt.	Iron	102-106	ferrochelatase	Rattus norvegicus	310-324
1513328-10	1992	We suggest that this tilting reflects the normal conformational changes required for the insertion of iron into the protoporphyrin IX ring by ferrochelatase and that the greater inhibitory activity of NA and epi-NB isomers, compared with epi-NA and NB isomers, is due to the fact that the normal mechanism for ferrochelatase-catalyzed iron insertion has preference for an A-C ring tilt over a B-D ring tilt.	Iron	335-339	ferrochelatase	Rattus norvegicus	142-156
1445180-0	1992	The relationship between homozygosity level and animal physiology: iron content of plasma and whole blood as well as total iron binding capacity by transferrin (TIBC) in rats of various inbreeding coefficient.	Iron	123-127	transferrin	Rattus norvegicus	148-159
1476702-6	1992	The excess iron uptake was reduced by the intravenous injection of either human transferrin or ovalbumin, and it was abolished by administering both.	Iron	11-15	transferrin	Homo sapiens	80-91
1407756-2	1992	Genetic analysis indicates that a heritable, but unidentified, trait may account for a substantial portion of the variability in transferrin saturation seen in persons with iron overload.	Iron	173-177	transferrin	Homo sapiens	129-140
1627803-2	1992	In the present study, we examined the effect of gallium on Tf-independent iron uptake by HL60 cells.	Iron	74-78	transferrin	Homo sapiens	59-61
1497657-0	1992	Identification of the iron-binding histidine residues in soybean lipoxygenase L-1.	Iron	22-26	seed linoleate 13S-lipoxygenase-1	Glycine max	65-81
1627803-3	1992	In contrast to the inhibitory effect of Tf-gallium on Tf-iron uptake, gallium nitrate, in a time-, temperature-, and concentration-dependent manner, stimulated Tf-independent uptake of iron-nitrilotriacetic acid (Fe-NTA).	Iron	57-61	transferrin	Homo sapiens	54-56
1627803-0	1992	Regulatory effects of gallium on transferrin-independent iron uptake by human leukemic HL60 cells.	Iron	57-61	transferrin	Homo sapiens	33-44
1627803-3	1992	In contrast to the inhibitory effect of Tf-gallium on Tf-iron uptake, gallium nitrate, in a time-, temperature-, and concentration-dependent manner, stimulated Tf-independent uptake of iron-nitrilotriacetic acid (Fe-NTA).	Iron	57-61	transferrin	Homo sapiens	54-56
1627803-1	1992	Gallium, a pharmacologically important metal, resembles iron with respect to transferrin (Tf) binding and Tf receptor-mediated cellular uptake.	Iron	56-60	transferrin	Homo sapiens	77-88
1627803-1	1992	Gallium, a pharmacologically important metal, resembles iron with respect to transferrin (Tf) binding and Tf receptor-mediated cellular uptake.	Iron	56-60	transferrin	Homo sapiens	90-92
1629195-0	1992	Two mechanisms of iron uptake from transferrin by melanoma cells.	Iron	18-22	transferrin	Homo sapiens	35-46
1627803-5	1992	The anti-Tf receptor monoclonal antibody 42/6 blocked Tf-iron uptake, but had no effect on gallium-induced stimulation of Tf-independent iron uptake.	Iron	57-61	transferrin	Homo sapiens	9-11
1627803-5	1992	The anti-Tf receptor monoclonal antibody 42/6 blocked Tf-iron uptake, but had no effect on gallium-induced stimulation of Tf-independent iron uptake.	Iron	57-61	transferrin	Homo sapiens	54-56
1627803-5	1992	The anti-Tf receptor monoclonal antibody 42/6 blocked Tf-iron uptake, but had no effect on gallium-induced stimulation of Tf-independent iron uptake.	Iron	57-61	transferrin	Homo sapiens	54-56
1627803-9	1992	Gallium and iron appear to share the same Tf-independent cellular uptake system in HL60 cells.	Iron	12-16	transferrin	Homo sapiens	42-44
1627803-10	1992	Exposure of cells to gallium results in the activation of cell membrane non-Tf iron carriers that may play a role in overcoming the Tf-independent growth-inhibitory effects of gallium.	Iron	79-83	transferrin	Homo sapiens	76-78
1627803-10	1992	Exposure of cells to gallium results in the activation of cell membrane non-Tf iron carriers that may play a role in overcoming the Tf-independent growth-inhibitory effects of gallium.	Iron	79-83	transferrin	Homo sapiens	132-134
1449722-4	1992	In the presence of the proteoglycan at pH 5.6, the release of iron from the N-lobe of transferrin was accelerated.	Iron	62-66	transferrin	Rattus norvegicus	86-97
1618820-1	1992	Incubation of phenyldiazene (PhN = NH) with lanosterol 14 alpha-demethylase, a cytochrome P-450 enzyme (CYP51) that oxidatively removes the 14 alpha-methyl group of lanosterol, results in the appearance of a 478-nm band indicative of phenyl-iron complex formation.	Iron	241-245	sterol 14-demethylase	Saccharomyces cerevisiae S288C	104-109
1442178-0	1992	[Assessment of iron requirements during treatment of anemia with recombinant human erythropoietin in patients with chronic renal insufficiency under hemodialysis].	Iron	15-19	erythropoietin	Homo sapiens	83-97
1442178-6	1992	Iron deficiency was detected (transferrin iron saturation less than 16% or serum ferritin less than 30 ng/ml) in 5 of the 10 patients.	Iron	42-46	transferrin	Homo sapiens	30-41
1442178-10	1992	Falls in the transferrin iron saturation during the Correction Period and 3, 6 and 12 months and in the serum ferritin at 3, 6 and 12 months versus Pre-rhEPO have occurred.	Iron	25-29	transferrin	Homo sapiens	13-24
1322122-5	1992	Addition of FeCl3 to the medium appeared to decrease the inhibitory effect of zinc on hypoxia-induced EPO synthesis, implying that zinc may interfere with an iron-dependent step in EPO regulation.	Iron	158-162	erythropoietin	Homo sapiens	102-105
1322122-5	1992	Addition of FeCl3 to the medium appeared to decrease the inhibitory effect of zinc on hypoxia-induced EPO synthesis, implying that zinc may interfere with an iron-dependent step in EPO regulation.	Iron	158-162	erythropoietin	Homo sapiens	181-184
1416028-0	1992	Preparation of iron-deficient tissue culture medium by deferoxamine-sepharose treatment and application to the differential actions of apotransferrin and diferric transferrin.	Iron	15-19	transferrin	Rattus norvegicus	138-149
1612763-0	1992	Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b. Haemophilus influenzae type b acquires transferrin-bound iron via a siderophore-independent mechanism involving direct contact between the human iron-binding glycoprotein and the bacterial cell surface.	Iron	155-159	transferrin	Homo sapiens	35-46
1612763-0	1992	Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b. Haemophilus influenzae type b acquires transferrin-bound iron via a siderophore-independent mechanism involving direct contact between the human iron-binding glycoprotein and the bacterial cell surface.	Iron	155-159	transferrin	Homo sapiens	137-148
1612763-1	1992	Evidence has accumulated to show that the transferrin receptor consists of at least two iron-regulated outer membrane transferrin-binding proteins (TBPs), of which one has a molecular mass of around 100 kDa (TBP1) and the other has a molecular mass of 60 to 90 kDa (TBP2).	Iron	88-92	transferrin	Homo sapiens	42-53
1612763-1	1992	Evidence has accumulated to show that the transferrin receptor consists of at least two iron-regulated outer membrane transferrin-binding proteins (TBPs), of which one has a molecular mass of around 100 kDa (TBP1) and the other has a molecular mass of 60 to 90 kDa (TBP2).	Iron	88-92	transferrin	Homo sapiens	118-129
1613505-8	1992	It is proposed that the uptake of iron into brain involves the entry of iron-loaded transferrin to the cerebral capillaries, deposition of iron within the endothelial cells, followed by recycling of apotransferrin to the circulation.	Iron	34-38	transferrin	Rattus norvegicus	84-95
1613505-8	1992	It is proposed that the uptake of iron into brain involves the entry of iron-loaded transferrin to the cerebral capillaries, deposition of iron within the endothelial cells, followed by recycling of apotransferrin to the circulation.	Iron	72-76	transferrin	Rattus norvegicus	84-95
1613505-8	1992	It is proposed that the uptake of iron into brain involves the entry of iron-loaded transferrin to the cerebral capillaries, deposition of iron within the endothelial cells, followed by recycling of apotransferrin to the circulation.	Iron	72-76	transferrin	Rattus norvegicus	84-95
1613505-9	1992	The deposited iron is then delivered to brain-derived transferrin for extracellular transport within the brain, and subsequently taken up via transferrin receptors on neurones and glia for usage or storage.	Iron	14-18	transferrin	Rattus norvegicus	54-65
1613505-9	1992	The deposited iron is then delivered to brain-derived transferrin for extracellular transport within the brain, and subsequently taken up via transferrin receptors on neurones and glia for usage or storage.	Iron	14-18	transferrin	Rattus norvegicus	142-153
1622403-6	1992	The 59Fe-labelling profiles of mucosal ferritin and transferrin from a test dose also were changed substantially in response to very-short-term alterations in dietary iron.	Iron	167-171	transferrin	Rattus norvegicus	52-63
1622403-7	1992	Even though changes in dietary iron rapidly altered iron uptake by brush-border membrane vesicles and the incorporation of 59Fe from the test dose into mucosal transferrin, changes in the incorporation of 59Fe into mucosal ferritin best reflected the actual changes in the transfer of iron from dose to plasma.	Iron	31-35	transferrin	Rattus norvegicus	160-171
1619445-0	1992	Clinically-silent mutation in the putative iron-responsive element in exon 17 of the beta-amyloid precursor protein gene.	Iron	43-47	amyloid beta precursor protein	Homo sapiens	85-115
1620595-8	1992	Furthermore, the distinction between the mechanism of regulation exerted by IFN gamma and that exerted by cell proliferation on transferrin receptor gene expression suggests that, in WISH cells, the IFN-induced transferrin receptor decay is not a consequence of cell growth arrest but rather one of the causes of the antiproliferative effect of IFN through iron deprivation.	Iron	357-361	transferrin	Homo sapiens	211-222
1620595-8	1992	Furthermore, the distinction between the mechanism of regulation exerted by IFN gamma and that exerted by cell proliferation on transferrin receptor gene expression suggests that, in WISH cells, the IFN-induced transferrin receptor decay is not a consequence of cell growth arrest but rather one of the causes of the antiproliferative effect of IFN through iron deprivation.	Iron	357-361	interferon alpha 1	Homo sapiens	199-202
1394690-0	1992	Site-specific cleavage of glycated human serum albumin in the presence of iron.	Iron	74-78	albumin	Homo sapiens	41-54
1586744-1	1992	Lactoferrin is a member of the transferrin family of iron-binding proteins.	Iron	53-57	transferrin	Homo sapiens	31-42
1321002-7	1992	A progressive decrease in the frequency of the labelling of the germ cells by transferrin-gold particles was observed from spermatogonia to spermatocytes and to early spermatids, which could indicate that iron is particularly required by germ cells during the mitotic and meiotic processes.	Iron	205-209	transferrin	Homo sapiens	78-89
1587306-0	1992	Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1.	Iron	0-4	interferon gamma	Homo sapiens	15-31
1358548-0	1992	Effects of copper, iron and zinc on oedema formation induced by phospholipase A2.	Iron	19-23	phospholipase A2 group IB	Homo sapiens	64-80
1358548-6	1992	Copper, iron and zinc have an inhibitory effect on vascular permeability increase and paw oedema induced by PLA2.	Iron	8-12	phospholipase A2 group IB	Homo sapiens	108-112
1358548-8	1992	Copper and iron could have not only a direct effect on PLA2 but on enzymes of arachidonic acid cascade.	Iron	11-15	phospholipase A2 group IB	Homo sapiens	55-59
1376697-1	1992	The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma.	Iron	51-55	transferrin	Homo sapiens	33-44
1587306-3	1992	The iron-mediated inhibition of the effects of IFN-gamma is fully reversed when iron is administered concomitantly with equimolar concentrations of the iron chelator deferoxamine.	Iron	4-8	interferon gamma	Homo sapiens	47-56
1587306-3	1992	The iron-mediated inhibition of the effects of IFN-gamma is fully reversed when iron is administered concomitantly with equimolar concentrations of the iron chelator deferoxamine.	Iron	80-84	interferon gamma	Homo sapiens	47-56
1587306-3	1992	The iron-mediated inhibition of the effects of IFN-gamma is fully reversed when iron is administered concomitantly with equimolar concentrations of the iron chelator deferoxamine.	Iron	80-84	interferon gamma	Homo sapiens	47-56
1587306-0	1992	Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1.	Iron	0-4	GLI family zinc finger 2	Homo sapiens	78-83
1587306-5	1992	Our data provide evidence that there is an inverse correlation between the intracellular amount of iron, which is not bound to ferritin, and the activity of the IFN-gamma signal.	Iron	99-103	interferon gamma	Homo sapiens	161-170
1587306-6	1992	This suggests that iron withholding by the immune cells in the course of inflammatory disorders may also contribute to the enhancement of the cytopathic effect of IFN-gamma.	Iron	19-23	interferon gamma	Homo sapiens	163-172
1587306-1	1992	This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens.	Iron	98-102	transferrin	Homo sapiens	80-91
1587306-1	1992	This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens.	Iron	98-102	interferon gamma	Homo sapiens	132-148
1587306-1	1992	This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens.	Iron	98-102	interferon gamma	Homo sapiens	150-159
1587306-1	1992	This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens.	Iron	98-102	GLI family zinc finger 2	Homo sapiens	206-211
1588135-0	1992	Iron acquisition in Haemophilus influenzae: receptors for human transferrin.	Iron	0-4	transferrin	Homo sapiens	64-75
1588135-1	1992	As an adaptation to the iron-limited environment of the host, Haemophilus influenzae has a transferrin receptor-mediated mechanism of iron acquisition such that it can acquire iron directly from human transferrin.	Iron	24-28	transferrin	Homo sapiens	91-102
1588135-1	1992	As an adaptation to the iron-limited environment of the host, Haemophilus influenzae has a transferrin receptor-mediated mechanism of iron acquisition such that it can acquire iron directly from human transferrin.	Iron	24-28	transferrin	Homo sapiens	201-212
1588135-1	1992	As an adaptation to the iron-limited environment of the host, Haemophilus influenzae has a transferrin receptor-mediated mechanism of iron acquisition such that it can acquire iron directly from human transferrin.	Iron	40-44	transferrin	Homo sapiens	91-102
1588135-1	1992	As an adaptation to the iron-limited environment of the host, Haemophilus influenzae has a transferrin receptor-mediated mechanism of iron acquisition such that it can acquire iron directly from human transferrin.	Iron	40-44	transferrin	Homo sapiens	201-212
1588135-1	1992	As an adaptation to the iron-limited environment of the host, Haemophilus influenzae has a transferrin receptor-mediated mechanism of iron acquisition such that it can acquire iron directly from human transferrin.	Iron	40-44	transferrin	Homo sapiens	91-102
1588135-1	1992	As an adaptation to the iron-limited environment of the host, Haemophilus influenzae has a transferrin receptor-mediated mechanism of iron acquisition such that it can acquire iron directly from human transferrin.	Iron	40-44	transferrin	Homo sapiens	201-212
1588135-5	1992	Affinity isolation experiments indicate that, as observed with other bacterial pathogens, the receptor is composed of two iron-repressible outer membrane proteins, transferrin binding proteins 1 and 2.	Iron	122-126	transferrin	Homo sapiens	164-175
1314661-5	1992	We confirmed that cytochrome c553 is the endogenous donor to P840+, and at room temperature we observed a recombination reaction between the reduced terminal acceptor and P840+ with a t1/2 = 7 ms. Oxidative degradation of iron-sulfur centers using low concentrations of chaotropic salts introduced a faster recombination reaction of t1/2 = 50 microseconds which was lost at higher concentrations of chaotrope, indicating the participation of another iron-sulfur redox center earlier than the terminal acceptor.	Iron	222-226	cytochrome c, somatic	Homo sapiens	18-30
1314661-5	1992	We confirmed that cytochrome c553 is the endogenous donor to P840+, and at room temperature we observed a recombination reaction between the reduced terminal acceptor and P840+ with a t1/2 = 7 ms. Oxidative degradation of iron-sulfur centers using low concentrations of chaotropic salts introduced a faster recombination reaction of t1/2 = 50 microseconds which was lost at higher concentrations of chaotrope, indicating the participation of another iron-sulfur redox center earlier than the terminal acceptor.	Iron	450-454	cytochrome c, somatic	Homo sapiens	18-30
1568461-8	1992	It is suggested that lymphocytes take up iron from non-transferrin iron donors by processes different from the iron uptake pathway used by transferrin.	Iron	41-45	transferrin	Homo sapiens	55-66
1584791-6	1992	These findings accurately mirror the physiological basis for iron regulation of transferrin receptor mRNA stability as well as ferritin and erythroid 5-aminolevulinate synthase mRNA translation in vivo.	Iron	61-65	transferrin	Homo sapiens	80-91
1315745-1	1992	Recombinant cytochrome c peroxidase (CcP) and a W51A mutant of CcP, in contrast to other classical peroxidases, react with phenylhydrazine to give sigma-bonded phenyl-iron complexes.	Iron	167-171	cytochrome c, somatic	Homo sapiens	12-24
1567206-9	1992	Superoxide dismutase, catalase, and mannitol inhibited UROX catalyzed by xanthine oxidase/iron-EDTA, but did not affect UROX catalyzed by either microsomes or reconstituted P450IA2.	Iron	90-94	catalase	Mus musculus	22-30
1597581-1	1992	Two iron-binding proteins, lactoferrin and transferrin, are present in ruminant milk.	Iron	4-8	lactotransferrin	Ovis aries	27-38
1567848-0	1992	Receptor-induced switch in site-site cooperativity during iron release by transferrin.	Iron	58-62	transferrin	Homo sapiens	74-85
1322952-0	1992	Exogenous siderophore-mediated iron uptake in Pseudomonas aeruginosa: possible involvement of porin OprF in iron translocation.	Iron	108-112	porin	Pseudomonas aeruginosa PAO1	94-99
1564573-0	1992	Soybean protein isolate and soybean lectin inhibit iron absorption in rats.	Iron	51-55	LOW QUALITY PROTEIN: lectin	Glycine max	36-42
1564573-1	1992	Inhibitory effects of soybean protein isolate (SPI) and soybean lectin on the intestinal absorption of nonheme iron were investigated by in vivo studies in rats.	Iron	111-115	LOW QUALITY PROTEIN: lectin	Glycine max	64-70
1564573-7	1992	Soybean lectin introduced into ligated segments of the upper small intestine of rats inhibited ferrous iron absorption.	Iron	95-107	LOW QUALITY PROTEIN: lectin	Glycine max	8-14
1465668-7	1992	Pretreatment long-term dialyzed, polytransfused and iron overloaded pts, even when treated with lower doses of rH-EPO, responded better, reaching target Hb level from the 8th- to the 16th week.	Iron	52-56	erythropoietin	Homo sapiens	114-117
1570306-4	1992	FRE1 mRNA levels are repressed by iron.	Iron	34-38	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-4
1570306-5	1992	Fusion of 977 base pairs of FRE1 DNA upstream from the translation start site of an Escherichia coli lacZ reporter gene confers iron-dependent regulation on expression of beta-galactosidase in yeast.	Iron	128-132	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	28-32
1570306-6	1992	An 85-base-pair segment of FRE1 5" noncoding sequence contains a RAP1 binding site and a repeated sequence, TTTTTGCTCAYC; this segment is sufficient to confer iron-repressible transcriptional activity on heterologous downstream promoter elements.	Iron	159-163	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	27-31
1575732-0	1992	Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase.	Iron	63-67	arachidonate 5-lipoxygenase	Homo sapiens	102-116
1567848-1	1992	Iron removal by PPi from the N- and C-terminal binding sites of both free and receptor-complexed transferrin, when the partner site remains occupied with kinetically inert Co(III), has been studied at pH 7.4 and 5.6, at 25 degrees C. At extracellular pH, 7.4, the C-terminal site of free mixed-metal proteins is slightly more labile than its N-terminal counterpart in releasing iron to 0.05 M PPi.	Iron	0-4	transferrin	Homo sapiens	97-108
1567848-1	1992	Iron removal by PPi from the N- and C-terminal binding sites of both free and receptor-complexed transferrin, when the partner site remains occupied with kinetically inert Co(III), has been studied at pH 7.4 and 5.6, at 25 degrees C. At extracellular pH, 7.4, the C-terminal site of free mixed-metal proteins is slightly more labile than its N-terminal counterpart in releasing iron to 0.05 M PPi.	Iron	0-4	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	172-179
1567848-6	1992	Iron release from the C-terminal site of receptor-complexed CoN-transferrin-FeC is 4 times faster than that from receptor-free protein.	Iron	0-4	transferrin	Homo sapiens	64-75
1567848-7	1992	In contrast, iron removal from the N-terminal site of receptor-complexed FeN-transferrin-CoC is slowed by a factor of 2 compared to that from free protein.	Iron	13-17	transferrin	Homo sapiens	77-88
1567848-8	1992	These results help explain our previous observation of a receptor-induced switch in site lability during iron removal from diferric transferrin at pH 5.6 (Bali &amp; Aisen, 1991).	Iron	105-109	transferrin	Homo sapiens	132-143
1567848-9	1992	Site-site cooperative interactions between the two sites of doubly-occupied transferrin during iron release are altered upon binding to receptor at pH 5.6.	Iron	95-99	transferrin	Homo sapiens	76-87
1550349-10	1992	The antioxidants mannitol and benzoate, as well as the iron chelator deferoxamine, reduced the extent of TNF alpha-induced oxidant effects in hepatocytes, which indicates that the oxidant stress may involve hydroxyl radical generation.	Iron	55-59	tumor necrosis factor	Mus musculus	105-114
1559997-3	1992	266, 20011-20017) we demonstrated the existence of a M(r) 66,000 microsomal iron protein (MIP) which stimulates NADPH oxidation by shunting electrons from NADPH-cytochrome P-450 reducase to its bound Fe(III).	Iron	76-80	major intrinsic protein of lens fiber	Homo sapiens	90-93
1559997-7	1992	However, the reconstitution of MIP from apoMIP and Fe(II) had to be performed in the presence of detergents to prevent the formation of protein aggregates and the oxidative incorporation of an iron which could not react with NADPH-cytochrome P-450 reductase.	Iron	193-197	major intrinsic protein of lens fiber	Homo sapiens	31-34
1312802-12	1992	If the formation of this complex is prevented by SOD, EDTA, or neocuproine, then OP may complex iron and the net effect may be (like dipyridyl) an inhibition of strand breaks.	Iron	96-100	superoxide dismutase 1	Homo sapiens	49-52
1312808-0	1992	Transferrin: a potential source of iron for oxygen free radical-mediated endothelial cell injury.	Iron	35-39	transferrin	Homo sapiens	0-11
1550358-1	1992	Lactotransferrin is an iron-binding protein.	Iron	23-27	lactotransferrin	Homo sapiens	0-16
1312808-3	1992	Addition of holosaturated transferrin potentiated H2O2-mediated RPAEC cytotoxicity at concentrations of H2O2 greater than 10 microM, suggesting that transferrin may provide a source of iron for free radical-mediated endothelial cell injury.	Iron	185-189	transferrin	Homo sapiens	26-37
1312808-3	1992	Addition of holosaturated transferrin potentiated H2O2-mediated RPAEC cytotoxicity at concentrations of H2O2 greater than 10 microM, suggesting that transferrin may provide a source of iron for free radical-mediated endothelial cell injury.	Iron	185-189	transferrin	Homo sapiens	149-160
1312808-5	1992	The ability of RPAECs to facilitate the release of iron from transferrin was assessed.	Iron	51-55	transferrin	Homo sapiens	61-72
1312808-6	1992	We determined that RPAECs facilitate the release of transferrin-derived iron by reduction of transferrin-bound ferric iron (Fe3+) to ferrous iron (Fe2+).	Iron	72-76	transferrin	Homo sapiens	52-63
1312808-6	1992	We determined that RPAECs facilitate the release of transferrin-derived iron by reduction of transferrin-bound ferric iron (Fe3+) to ferrous iron (Fe2+).	Iron	72-76	transferrin	Homo sapiens	93-104
1312808-6	1992	We determined that RPAECs facilitate the release of transferrin-derived iron by reduction of transferrin-bound ferric iron (Fe3+) to ferrous iron (Fe2+).	Iron	118-122	transferrin	Homo sapiens	52-63
1312808-6	1992	We determined that RPAECs facilitate the release of transferrin-derived iron by reduction of transferrin-bound ferric iron (Fe3+) to ferrous iron (Fe2+).	Iron	118-122	transferrin	Homo sapiens	93-104
1312808-9	1992	In contrast, exogenous SOD did not alter iron release, suggesting that intracellular superoxide anion (O2-) may play an important role in mediating the reduction and release of transferrin-derived iron.	Iron	197-201	superoxide dismutase 1	Homo sapiens	23-26
1312808-9	1992	In contrast, exogenous SOD did not alter iron release, suggesting that intracellular superoxide anion (O2-) may play an important role in mediating the reduction and release of transferrin-derived iron.	Iron	197-201	transferrin	Homo sapiens	177-188
1312808-10	1992	Results of this study suggest that transferrin may provide a source of iron for oxygen free radical-mediated endothelial cell injury and identify a novel mechanism by which endothelial cells may mediate the reduction and release of transferrin-derived iron.	Iron	71-75	transferrin	Homo sapiens	35-46
1312808-10	1992	Results of this study suggest that transferrin may provide a source of iron for oxygen free radical-mediated endothelial cell injury and identify a novel mechanism by which endothelial cells may mediate the reduction and release of transferrin-derived iron.	Iron	252-256	transferrin	Homo sapiens	35-46
1312808-10	1992	Results of this study suggest that transferrin may provide a source of iron for oxygen free radical-mediated endothelial cell injury and identify a novel mechanism by which endothelial cells may mediate the reduction and release of transferrin-derived iron.	Iron	252-256	transferrin	Homo sapiens	232-243
1558977-1	1992	To determine whether release of tumor necrosis factor-alpha (TNF-alpha), a cytokine that affects iron homeostasis, may be selectively altered in hereditary hemochromatosis, we measured concentrations of TNF-alpha and interleukin-1 beta (IL-1 beta) in supernatants of cultured peripheral blood monocytes from 11 homozygotes for hereditary hemochromatosis, 11 healthy individuals, and five patients with iron-loading anemia.	Iron	97-101	tumor necrosis factor	Homo sapiens	61-70
1558977-5	1992	Mean concentrations of immunoreactive TNF-alpha in supernatants were significantly lower for subjects with hereditary hemochromatosis as compared to healthy controls (P less than .037) and patients with iron-loading anemia (P less than .005); differences between homozygotes for hemochromatosis and healthy controls were up to 4.5-fold at 4 hours (P = .008), 1.9-fold at 12 hours (P = .036), and 7.0-fold at 36 hours (P = .001).	Iron	203-207	tumor necrosis factor	Homo sapiens	38-47
1558977-1	1992	To determine whether release of tumor necrosis factor-alpha (TNF-alpha), a cytokine that affects iron homeostasis, may be selectively altered in hereditary hemochromatosis, we measured concentrations of TNF-alpha and interleukin-1 beta (IL-1 beta) in supernatants of cultured peripheral blood monocytes from 11 homozygotes for hereditary hemochromatosis, 11 healthy individuals, and five patients with iron-loading anemia.	Iron	97-101	tumor necrosis factor	Homo sapiens	32-59
1568318-0	1992	Elimination of fibrinogen interference in a dye-binding method for iron.	Iron	67-71	fibrinogen beta chain	Homo sapiens	15-25
1426911-0	1992	[Transferrin iron-binding capacity in hypersideremia].	Iron	13-17	transferrin	Homo sapiens	1-12
1525853-1	1992	The PAR1/SNQ3 gene of S. cerevisiae, which increases resistance to iron chelators in multi-copy transformants, is identical to the YAP1 gene, a yeast activator protein isolated as a functional homologue of the human c-jun oncogene by binding specifically to the AP-1 consensus box.	Iron	67-71	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	4-8
1525853-1	1992	The PAR1/SNQ3 gene of S. cerevisiae, which increases resistance to iron chelators in multi-copy transformants, is identical to the YAP1 gene, a yeast activator protein isolated as a functional homologue of the human c-jun oncogene by binding specifically to the AP-1 consensus box.	Iron	67-71	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	9-13
1525853-1	1992	The PAR1/SNQ3 gene of S. cerevisiae, which increases resistance to iron chelators in multi-copy transformants, is identical to the YAP1 gene, a yeast activator protein isolated as a functional homologue of the human c-jun oncogene by binding specifically to the AP-1 consensus box.	Iron	67-71	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	131-135
1426911-2	1992	Interrelation has been shown between transferrin and general serum iron-binding capacity.	Iron	67-71	transferrin	Homo sapiens	37-48
1426914-3	1992	Information on transferrin saturation with iron, erythrocytic ferritins and, particularly, serum ferritin, was most valuable in the estimation of iron deficiency.	Iron	43-47	transferrin	Homo sapiens	15-26
1316854-2	1992	Adrenodoxin is the iron/sulfur protein donating electrons to P-450scc during this reaction.	Iron	19-23	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	61-69
1526963-0	1992	Effect of ascorbate in the reduction of transferrin-associated iron in endocytic vesicles.	Iron	63-67	transferrin	Homo sapiens	40-51
1526963-3	1992	At physiological concentrations of both ascorbate and NADH, the ascorbate transport and the NADH-oxidoreductase system were additive as measured by the rate of reduction of ferricyanide and by the mobilization of transferrin-associated iron.	Iron	236-240	transferrin	Homo sapiens	213-224
1526963-5	1992	The ascorbate-mediated reduction of iron derived from transferrin occurring in the endosome could play a major role in cellular iron uptake.	Iron	36-40	transferrin	Homo sapiens	54-65
1526963-5	1992	The ascorbate-mediated reduction of iron derived from transferrin occurring in the endosome could play a major role in cellular iron uptake.	Iron	128-132	transferrin	Homo sapiens	54-65
1311994-3	1992	), or to desferrioxamine (DFX), an iron chelator preventing the synthesis of OH., enhanced the specific binding of 125I-TNF-alpha to its receptors.	Iron	35-39	tumor necrosis factor	Homo sapiens	120-129
1312087-8	1992	In addition, the toxic effects of TNF were counteracted by the addition of antioxidants and iron chelators.	Iron	92-96	tumor necrosis factor	Mus musculus	34-37
1562281-3	1992	Twenty-four hours after iron treatment, a significant increase in aspartate aminotransferase and lactate dehydrogenase in the culture medium was observed.	Iron	24-28	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	66-92
1313648-5	1992	In the experiments for assessing the effect of various scavengers, 1O2 scavenger histidine or iron chelator deferoxamine effectively protected the attenuation induced by DHF/Fe(3+)-ADP exposure of the relaxation elicited by acetylcholine; superoxide dismutase (SOD), catalase, or dimethyl sulfoxide (DMSO) had no effect on this system.	Iron	94-98	catalase	Canis lupus familiaris	267-275
1313652-6	1992	The plasma iron response was directly related to the erythropoietin stimulus (r = 0.79, P less than 0.001) and inversely related to liver iron concentration at death (r = -0.84, P less than 0.001).	Iron	11-15	erythropoietin	Homo sapiens	53-67
1540797-0	1992	Possible downregulating effects of increased iron stores on erythropoietin responsiveness in rheumatoid arthritis.	Iron	45-49	erythropoietin	Homo sapiens	60-74
1326072-7	1992	Superoxide dismutase and catalase can affect lipid peroxidation by affecting iron reduction/oxidation and the formation of a (1:1) Fe2+/Fe3+ ratio.	Iron	77-81	catalase	Homo sapiens	25-33
1512033-3	1992	It is speculated that transferrin or a transferrin-like protein present in the cell wall may play a role in iron-uptake by S. typhi.	Iron	108-112	transferrin	Homo sapiens	22-33
1512033-3	1992	It is speculated that transferrin or a transferrin-like protein present in the cell wall may play a role in iron-uptake by S. typhi.	Iron	108-112	transferrin	Homo sapiens	39-50
1640494-2	1992	Most cells acquire iron through a specific receptor mediated process involving transferrin, the iron mobilization protein.	Iron	19-23	transferrin	Rattus norvegicus	79-90
1640494-2	1992	Most cells acquire iron through a specific receptor mediated process involving transferrin, the iron mobilization protein.	Iron	96-100	transferrin	Rattus norvegicus	79-90
1537518-1	1992	To gain insights at the molecular level into the expression of iron-regulated genes [transferrin (Tf), transferrin receptor (TfR), and ferritin H and L subunits] in human intestinal areas relevant to iron absorption, the steady-state levels of specific messenger RNAs (mRNAs) were analyzed in gastric and duodenal samples obtained from 6 normal subjects, or 10 patients with anemia, 14 patients with untreated iron overload, and 8 patients with various gastrointestinal disorders.	Iron	63-67	transferrin	Homo sapiens	85-96
1537518-1	1992	To gain insights at the molecular level into the expression of iron-regulated genes [transferrin (Tf), transferrin receptor (TfR), and ferritin H and L subunits] in human intestinal areas relevant to iron absorption, the steady-state levels of specific messenger RNAs (mRNAs) were analyzed in gastric and duodenal samples obtained from 6 normal subjects, or 10 patients with anemia, 14 patients with untreated iron overload, and 8 patients with various gastrointestinal disorders.	Iron	63-67	transferrin	Homo sapiens	98-100
1537518-1	1992	To gain insights at the molecular level into the expression of iron-regulated genes [transferrin (Tf), transferrin receptor (TfR), and ferritin H and L subunits] in human intestinal areas relevant to iron absorption, the steady-state levels of specific messenger RNAs (mRNAs) were analyzed in gastric and duodenal samples obtained from 6 normal subjects, or 10 patients with anemia, 14 patients with untreated iron overload, and 8 patients with various gastrointestinal disorders.	Iron	200-204	transferrin	Homo sapiens	85-96
1537518-1	1992	To gain insights at the molecular level into the expression of iron-regulated genes [transferrin (Tf), transferrin receptor (TfR), and ferritin H and L subunits] in human intestinal areas relevant to iron absorption, the steady-state levels of specific messenger RNAs (mRNAs) were analyzed in gastric and duodenal samples obtained from 6 normal subjects, or 10 patients with anemia, 14 patients with untreated iron overload, and 8 patients with various gastrointestinal disorders.	Iron	200-204	transferrin	Homo sapiens	85-96
1342483-4	1992	Therefore we recommend iron supplementation during the initial phase of treatment with erythropoietin until serum ferritin levels raise above 1000 ng/ml.	Iron	23-27	erythropoietin	Homo sapiens	87-101
1737056-0	1992	Effect of iron and retinoic acid on the control of transferrin receptor and ferritin in the human promonocytic cell line U937.	Iron	10-14	transferrin	Homo sapiens	51-62
1540191-0	1992	Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase.	Iron	63-67	arachidonate 5-lipoxygenase	Homo sapiens	102-116
1540191-1	1992	Human 5-lipoxygenase contains a non-heme iron essential for its activity.	Iron	41-45	arachidonate 5-lipoxygenase	Homo sapiens	6-20
1540191-6	1992	These results strongly suggest that His-367, His-372, His-550 and Glu-376 are crucial for 5-lipoxygenase activity and coordinate to the essential iron.	Iron	146-150	arachidonate 5-lipoxygenase	Homo sapiens	90-104
1737056-2	1992	Addition of iron (as 200 micrograms/ml saturated transferrin) or retinoic acid (1 microM) both caused approx.	Iron	12-16	transferrin	Homo sapiens	49-60
1539729-1	1992	Iron uptake from transferrin by a variety of cells and tissues of homozygous Belgrade laboratory rats was compared with heterozygotes, and normal and iron-deficient Wistar rats.	Iron	0-4	transferrin	Rattus norvegicus	17-28
1564445-3	1992	Increased dosage of FUP1 reduces the concentration of iron in the medium required for efficient growth and confers elevated levels of iron uptake activity in iron-limited cells.	Iron	54-58	Msn1p	Saccharomyces cerevisiae S288C	20-24
1550782-2	1992	Transferrin enhanced proliferation, the effect being proportional to the degree of iron saturation up to 100%, but decreased if additional iron was present.	Iron	83-87	transferrin	Homo sapiens	0-11
1550782-2	1992	Transferrin enhanced proliferation, the effect being proportional to the degree of iron saturation up to 100%, but decreased if additional iron was present.	Iron	139-143	transferrin	Homo sapiens	0-11
1550782-4	1992	Fe-lactoferrin could not substitute for Fe-transferrin, although iron-free (apo) lactoferrin abrogated the inhibitory effect seen when iron levels exceed the binding capacity of transferrin.	Iron	65-69	transferrin	Homo sapiens	178-189
1550782-5	1992	Lymphocyte ferritin levels increased 4-fold as the iron saturation of transferrin increased from 0 to 90% but no further increase was seen at higher iron levels, suggesting that lymphocytes are poorly equipped to detoxify excess iron through stimulation of ferritin synthesis.	Iron	51-55	transferrin	Homo sapiens	70-81
1550782-6	1992	The effect of iron on the CD4:CD8 ratio after 72 h culture with PHA was also examined.	Iron	14-18	CD4 molecule	Homo sapiens	26-29
1550782-7	1992	The ratio was approximately 2:1 for cells cultured with transferrin at iron saturations between 0 and 75%, with FePIH, or without either, but decreased to 1.1:1 when cells were cultured in the presence of FeNTA, regardless of whether or not saturated Fe-transferrin was present.	Iron	71-75	transferrin	Homo sapiens	56-67
1541000-1	1992	We studied the relationship between serum erythropoietin (EPO) concentration and iron status in 67 patients undergoing chronic hemodialysis.	Iron	81-85	erythropoietin	Homo sapiens	42-56
1541000-1	1992	We studied the relationship between serum erythropoietin (EPO) concentration and iron status in 67 patients undergoing chronic hemodialysis.	Iron	81-85	erythropoietin	Homo sapiens	58-61
1541000-7	1992	We found no significant correlation between concentrations of serum EPO and hemoglobin in hemodialysis patients, but found a significant negative correlation between serum concentrations of EPO and iron in hemodialysis patients.	Iron	198-202	erythropoietin	Homo sapiens	190-193
1541000-8	1992	Moreover, we also found a significant positive correlation between the EPO concentration and the unsaturated iron-binding capacity (UIBC) in serum, and a significant negative correlation between the serum concentrations of EPO and ferritin in hemodialysis patients.	Iron	109-113	erythropoietin	Homo sapiens	71-74
1541000-9	1992	Several patients who had relatively high EPO concentrations for hemodialysis patients also had low iron concentrations, high UIBC values, and low ferritin concentrations.	Iron	99-103	erythropoietin	Homo sapiens	41-44
1541000-10	1992	These findings suggest that iron was utilized even at these EPO concentrations, which were very low for the degree of anemia observed in the hemodialysis patients.	Iron	28-32	erythropoietin	Homo sapiens	60-63
1564445-3	1992	Increased dosage of FUP1 reduces the concentration of iron in the medium required for efficient growth and confers elevated levels of iron uptake activity in iron-limited cells.	Iron	134-138	Msn1p	Saccharomyces cerevisiae S288C	20-24
1564445-3	1992	Increased dosage of FUP1 reduces the concentration of iron in the medium required for efficient growth and confers elevated levels of iron uptake activity in iron-limited cells.	Iron	134-138	Msn1p	Saccharomyces cerevisiae S288C	20-24
1573683-9	1992	The decrease in transferrin levels could indicate a decreased mobility and subsequent utilization of iron in the brain.	Iron	101-105	transferrin	Homo sapiens	16-27
1564445-4	1992	Disruption of the FUP1 locus reduces wild-type iron uptake rates by 2-fold in cells grown on raffinose medium but has no effect on glucose-grown cells.	Iron	47-51	Msn1p	Saccharomyces cerevisiae S288C	18-22
1564445-6	1992	Our results suggest that FUP1/MSN1 also regulates synthesis of gene products involved in iron uptake.	Iron	89-93	Msn1p	Saccharomyces cerevisiae S288C	25-29
1310394-6	1992	These results show that at least one methionine is close to the iron binding site in soybean lipoxygenase-1.	Iron	64-68	seed linoleate 13S-lipoxygenase-1	Glycine max	93-107
1552848-6	1992	Iron has a negative effect on lasB-lacZ expression.	Iron	0-4	elastase LasB	Pseudomonas aeruginosa PAO1	30-34
1552848-10	1992	Later in the growth curve a slight increase in lasB-lacZ transcription was observed only in PAO1(pTS400) grown in low iron.	Iron	118-122	elastase LasB	Pseudomonas aeruginosa PAO1	47-51
1552848-11	1992	These results suggest that the iron regulation of lasB occurs predominantly at the translational level.	Iron	31-35	elastase LasB	Pseudomonas aeruginosa PAO1	50-54
1542922-6	1992	In both iron-supplemented and control patients, serum erythropoietin levels returned to initial values within a few days after surgery.	Iron	8-12	erythropoietin	Homo sapiens	54-68
1337651-2	1992	The best results were obtained from vitamin E and the antiinflammatory treatment with CP and SUL, whereas an iron elimination only showed slight effects on myeloperoxidase activity above all.	Iron	109-113	myeloperoxidase	Homo sapiens	156-171
1727237-3	1992	To examine the hypothesis that African iron overload also involves a genetic factor, we used likelihood analysis to test for an interaction between a gene (the hypothesized iron-loading locus) and an environmental factor (increased dietary iron) that determines transferrin saturation and unsaturated iron-binding capacity.	Iron	39-43	transferrin	Homo sapiens	262-273
1727237-3	1992	To examine the hypothesis that African iron overload also involves a genetic factor, we used likelihood analysis to test for an interaction between a gene (the hypothesized iron-loading locus) and an environmental factor (increased dietary iron) that determines transferrin saturation and unsaturated iron-binding capacity.	Iron	173-177	transferrin	Homo sapiens	262-273
1727237-3	1992	To examine the hypothesis that African iron overload also involves a genetic factor, we used likelihood analysis to test for an interaction between a gene (the hypothesized iron-loading locus) and an environmental factor (increased dietary iron) that determines transferrin saturation and unsaturated iron-binding capacity.	Iron	173-177	transferrin	Homo sapiens	262-273
1727237-3	1992	To examine the hypothesis that African iron overload also involves a genetic factor, we used likelihood analysis to test for an interaction between a gene (the hypothesized iron-loading locus) and an environmental factor (increased dietary iron) that determines transferrin saturation and unsaturated iron-binding capacity.	Iron	173-177	transferrin	Homo sapiens	262-273
1727237-7	1992	Among family members with increased dietary iron due to the consumption of traditional beer, transferrin saturation in serum was distributed bimodally, with 56 normal values (less than 60 percent saturation) and 44 elevated values; the mean serum ferritin concentration was five times higher in the subjects with elevated transferrin saturation (P less than 0.005).	Iron	44-48	transferrin	Homo sapiens	93-104
1727237-8	1992	The pedigree analysis provided evidence of both a genetic effect (P less than 0.005) and an effect of increased dietary iron (P less than 0.005) on transferrin saturation and unsaturated iron-binding capacity.	Iron	120-124	transferrin	Homo sapiens	148-159
1727237-9	1992	In the most likely model, increased dietary iron raised the mean transferrin saturation from 30 to 81 percent and lowered the mean unsaturated iron-binding capacity from 38 to 13 mumol per liter in subjects heterozygous for the iron-loading locus.	Iron	44-48	transferrin	Homo sapiens	65-76
1361844-1	1992	Iron supplementation is usually required in patients receiving epoetin alfa.	Iron	0-4	erythropoietin	Homo sapiens	63-70
1361760-1	1992	CAPD patients require supplemental iron to maintain a response to erythropoietin.	Iron	35-39	erythropoietin	Homo sapiens	66-80
1510381-7	1992	Transferrin is also involved in the transport of iron across the blood-brain barrier via transferrin receptors on brain capillary endothelial cells.	Iron	49-53	transferrin	Homo sapiens	89-100
1298300-5	1992	Myocytes maintained in HEPES buffer or the HEPES buffer containing purine and iron-loaded transferrin continued to stimulate, exhibited relatively uniform 340/380 nm ratios and maintained a rod shape.	Iron	78-82	transferrin	Rattus norvegicus	90-101
1510380-2	1992	Iron in blood plasma is totally bound to transferrin (Tf), a major plasma glycoprotein.	Iron	0-4	transferrin	Rattus norvegicus	41-52
1510380-2	1992	Iron in blood plasma is totally bound to transferrin (Tf), a major plasma glycoprotein.	Iron	0-4	transferrin	Rattus norvegicus	54-56
1510380-8	1992	It is likely that iron separates from Tf in early endosomes, which are assumed to be acidic, as they are in other cells, and enters the brain by an as yet undefined pathway.	Iron	18-22	transferrin	Rattus norvegicus	38-40
1536148-1	1992	The mechanism underlying the impaired uptake of iron from transferrin by reticulocytes from the Belgrade laboratory rat was investigated using 125I- and 59Fe-labeled transferrin isolated from homozygous Belgrade rats and from Wistar rats, nontransferrin-bound Fe(II) in an isotonic sucrose solution, and reticulocytes from Belgrade and Wistar rats.	Iron	48-52	transferrin	Rattus norvegicus	58-69
1536148-2	1992	The Belgrade rat transferrin had the same molecular weight and net charge as Wistar rat transferrin, donated iron equally well to both types of reticulocytes, and competed equally for transferrin binding sites on the cells.	Iron	109-113	transferrin	Rattus norvegicus	17-28
1510382-0	1992	Entry of iron into cells: a new role for the transferrin receptor in modulating iron release from transferrin.	Iron	9-13	transferrin	Homo sapiens	45-56
1510382-0	1992	Entry of iron into cells: a new role for the transferrin receptor in modulating iron release from transferrin.	Iron	9-13	transferrin	Homo sapiens	98-109
1510382-0	1992	Entry of iron into cells: a new role for the transferrin receptor in modulating iron release from transferrin.	Iron	80-84	transferrin	Homo sapiens	45-56
1510382-0	1992	Entry of iron into cells: a new role for the transferrin receptor in modulating iron release from transferrin.	Iron	80-84	transferrin	Homo sapiens	98-109
1510382-3	1992	Of these pathways, the most important and widely functioning is uptake of iron from transferrin in a receptor-mediated process.	Iron	74-78	transferrin	Homo sapiens	84-95
1510380-9	1992	A clonal line of brain capillary endothelial cells that mimics the BBB when grown on permeabilized membranes can transcytose iron provided as Fe55-Tf.	Iron	125-129	transferrin	Rattus norvegicus	147-149
1510381-4	1992	Transferrin, the iron transport protein, has been found predominantly in oligodendrocytes in the brain and in myelinating Schwann cells in the peripheral nervous system.	Iron	17-21	transferrin	Homo sapiens	0-11
1510381-7	1992	Transferrin is also involved in the transport of iron across the blood-brain barrier via transferrin receptors on brain capillary endothelial cells.	Iron	49-53	transferrin	Homo sapiens	0-11
1510382-4	1992	By regulating expression of the transferrin receptor, iron-dependent cells, including neurons, can be assured an adequate supply of the essential metal while guarding against toxic excess.	Iron	54-58	transferrin	Homo sapiens	32-43
1510382-5	1992	However, the transferrin receptor functions not only in capturing iron-bearing transferrin, but also in restraining release of iron from transferrin at the cell surface, where iron-catalyzed lipid peroxidation is a threat, while facilitating iron release in acidified endosomes to ensure safe and efficient delivery to the cell.	Iron	66-70	transferrin	Homo sapiens	13-24
1727652-6	1992	Another phospholipase A2 inhibitor, mepacrine, poorly inhibited both microsomal and pool-B"-promoted lipid peroxidation, but did block both iron-ascorbate-driven and ABAP-promoted lipid peroxidation.	Iron	140-144	phospholipase A2 group IB	Homo sapiens	8-24
1510382-5	1992	However, the transferrin receptor functions not only in capturing iron-bearing transferrin, but also in restraining release of iron from transferrin at the cell surface, where iron-catalyzed lipid peroxidation is a threat, while facilitating iron release in acidified endosomes to ensure safe and efficient delivery to the cell.	Iron	66-70	transferrin	Homo sapiens	79-90
1510382-5	1992	However, the transferrin receptor functions not only in capturing iron-bearing transferrin, but also in restraining release of iron from transferrin at the cell surface, where iron-catalyzed lipid peroxidation is a threat, while facilitating iron release in acidified endosomes to ensure safe and efficient delivery to the cell.	Iron	66-70	transferrin	Homo sapiens	79-90
1510382-5	1992	However, the transferrin receptor functions not only in capturing iron-bearing transferrin, but also in restraining release of iron from transferrin at the cell surface, where iron-catalyzed lipid peroxidation is a threat, while facilitating iron release in acidified endosomes to ensure safe and efficient delivery to the cell.	Iron	127-131	transferrin	Homo sapiens	13-24
1510382-5	1992	However, the transferrin receptor functions not only in capturing iron-bearing transferrin, but also in restraining release of iron from transferrin at the cell surface, where iron-catalyzed lipid peroxidation is a threat, while facilitating iron release in acidified endosomes to ensure safe and efficient delivery to the cell.	Iron	127-131	transferrin	Homo sapiens	13-24
1510382-5	1992	However, the transferrin receptor functions not only in capturing iron-bearing transferrin, but also in restraining release of iron from transferrin at the cell surface, where iron-catalyzed lipid peroxidation is a threat, while facilitating iron release in acidified endosomes to ensure safe and efficient delivery to the cell.	Iron	127-131	transferrin	Homo sapiens	13-24
1323982-0	1992	Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein.	Iron	0-4	transferrin	Homo sapiens	42-53
1323982-0	1992	Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein.	Iron	81-85	transferrin	Homo sapiens	42-53
1735118-1	1992	The present study examines events of the Sertoli cell iron delivery pathway following the secretion of diferric testicular transferrin (tTf) into the adluminal compartment of the rat seminiferous epithelium.	Iron	54-58	transferrin	Rattus norvegicus	123-134
1375080-5	1992	The binding of aluminum or chromium to apo-transferrin was reduced by 18 and 22% in the presence of 200 ng/mL of iron.	Iron	113-117	transferrin	Homo sapiens	43-54
1375084-0	1992	Interleukin 2 production in iron-deficient children.	Iron	28-32	interleukin 2	Homo sapiens	0-13
1375084-1	1992	The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children"s health centers in the Paris area.	Iron	25-29	interleukin 2	Homo sapiens	54-58
1375084-5	1992	IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children.	Iron	229-233	interleukin 2	Homo sapiens	0-4
1375084-5	1992	IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children.	Iron	229-233	lamin B receptor	Homo sapiens	47-50
1375084-5	1992	IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children.	Iron	229-233	interleukin 2	Homo sapiens	95-99
1375084-5	1992	IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children.	Iron	229-233	lamin B receptor	Homo sapiens	139-142
1375084-5	1992	IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children.	Iron	229-233	interleukin 2	Homo sapiens	95-99
1375084-5	1992	IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children.	Iron	229-233	lamin B receptor	Homo sapiens	139-142
1375084-6	1992	The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity.	Iron	83-87	interleukin 2	Homo sapiens	17-21
1375087-6	1992	Spectrophotometric titration of each individual amino acid located in the iron binding site of transferrin revealed that tyrosine might be the most suitable ligand for the binding of chromium to transferrin.	Iron	74-78	transferrin	Homo sapiens	95-106
1375087-6	1992	Spectrophotometric titration of each individual amino acid located in the iron binding site of transferrin revealed that tyrosine might be the most suitable ligand for the binding of chromium to transferrin.	Iron	74-78	transferrin	Homo sapiens	195-206
1375087-7	1992	These results suggest that chromium may compete with iron in binding to apo-transferrin, and influence iron metabolism and its related biochemical parameters.	Iron	53-57	transferrin	Homo sapiens	76-87
1581527-2	1992	Superoxide dismutase (SOD) increases the rates of iron release with the less filtered smoke extracts, but has no effect on the rate of iron release caused by aqueous extracts of well-filtered gas-phase cigarette smoke.	Iron	50-54	superoxide dismutase 1	Homo sapiens	0-20
1581527-2	1992	Superoxide dismutase (SOD) increases the rates of iron release with the less filtered smoke extracts, but has no effect on the rate of iron release caused by aqueous extracts of well-filtered gas-phase cigarette smoke.	Iron	50-54	superoxide dismutase 1	Homo sapiens	22-25
1295714-0	1992	Effect of recombinant human erythropoietin on iron balance in maintenance hemodialysis: theoretical considerations, clinical experience and consequences.	Iron	46-50	erythropoietin	Homo sapiens	28-42
1295714-2	1992	Serum ferritin and transferrin saturation give valuable information on storage iron and iron transport.	Iron	79-83	transferrin	Homo sapiens	19-30
1295714-2	1992	Serum ferritin and transferrin saturation give valuable information on storage iron and iron transport.	Iron	88-92	transferrin	Homo sapiens	19-30
1340486-3	1992	Considerable attention was given to the microheterogeneity of the transferrin molecule--the polymorphism, differences of the binding site for iron and possible donation of iron to the cell, number of carbohydrate antennae, degree of sialyzation--in connection to the possible link between microheterogeneity and physiological and pathophysiological status of the organism.	Iron	142-146	transferrin	Homo sapiens	66-77
1532495-3	1992	Siderophore-mediated iron uptake involves the synthesis of low molecular weight iron chelators called siderophores which compete with the host iron-binding glycoproteins lactoferrin (LF) and transferrin (TF) for iron.	Iron	21-25	transferrin	Homo sapiens	191-202
1532495-3	1992	Siderophore-mediated iron uptake involves the synthesis of low molecular weight iron chelators called siderophores which compete with the host iron-binding glycoproteins lactoferrin (LF) and transferrin (TF) for iron.	Iron	21-25	transferrin	Homo sapiens	204-206
1532495-3	1992	Siderophore-mediated iron uptake involves the synthesis of low molecular weight iron chelators called siderophores which compete with the host iron-binding glycoproteins lactoferrin (LF) and transferrin (TF) for iron.	Iron	80-84	transferrin	Homo sapiens	191-202
1532495-3	1992	Siderophore-mediated iron uptake involves the synthesis of low molecular weight iron chelators called siderophores which compete with the host iron-binding glycoproteins lactoferrin (LF) and transferrin (TF) for iron.	Iron	80-84	transferrin	Homo sapiens	204-206
1532495-3	1992	Siderophore-mediated iron uptake involves the synthesis of low molecular weight iron chelators called siderophores which compete with the host iron-binding glycoproteins lactoferrin (LF) and transferrin (TF) for iron.	Iron	80-84	transferrin	Homo sapiens	191-202
1532495-3	1992	Siderophore-mediated iron uptake involves the synthesis of low molecular weight iron chelators called siderophores which compete with the host iron-binding glycoproteins lactoferrin (LF) and transferrin (TF) for iron.	Iron	80-84	transferrin	Homo sapiens	204-206
1532495-4	1992	Other ways to induce iron uptake, without the mediation of siderophores, are the possession of outer membrane protein receptors that actually recognize the complex of TF or LF with iron, resulting in the internalization of this metal, and the use of heme-compounds released into the circulation after lysis of erythrocytes.	Iron	21-25	transferrin	Homo sapiens	167-169
1532495-4	1992	Other ways to induce iron uptake, without the mediation of siderophores, are the possession of outer membrane protein receptors that actually recognize the complex of TF or LF with iron, resulting in the internalization of this metal, and the use of heme-compounds released into the circulation after lysis of erythrocytes.	Iron	181-185	transferrin	Homo sapiens	167-169
1398274-1	1992	Iron transport in plasma is carried out by transferrin, which donates iron to cells through interaction with a specific membrane receptor.	Iron	0-4	transferrin	Homo sapiens	43-54
1398274-1	1992	Iron transport in plasma is carried out by transferrin, which donates iron to cells through interaction with a specific membrane receptor.	Iron	70-74	transferrin	Homo sapiens	43-54
1302169-2	1992	Diferric bovine transferrin labeled with 59Fe was used as an iron donor.	Iron	61-65	serotransferrin	Bos taurus	16-27
1302169-3	1992	We have shown the presence of saturable iron uptake when cells were incubated with varying concentrations of diferric transferrin.	Iron	40-44	serotransferrin	Bos taurus	118-129
1302169-8	1992	There were approximately 1.5 x 10(6) transferrin receptors per cell with a Kd of 9.1 x 10(-7) M in the physiological iron range.	Iron	117-121	serotransferrin	Bos taurus	37-48
1302169-9	1992	Iron was also taken up when the cells were incubated with radioactive ferrous iron without transferrin.	Iron	0-4	serotransferrin	Bos taurus	91-102
1302169-13	1992	It is proposed that iron is transported by bovine endothelial cells by two mechanisms: one is receptor-mediated endocytosis from transferrin, and the other involves a non-endocytic mechanism from transferrin and Fe2+, which is possibly promoted by Ca2+.	Iron	20-24	serotransferrin	Bos taurus	129-140
1302169-13	1992	It is proposed that iron is transported by bovine endothelial cells by two mechanisms: one is receptor-mediated endocytosis from transferrin, and the other involves a non-endocytic mechanism from transferrin and Fe2+, which is possibly promoted by Ca2+.	Iron	20-24	serotransferrin	Bos taurus	196-207
1478402-0	1992	[Non-transferrin-bound iron and hepatic iron load].	Iron	23-27	transferrin	Homo sapiens	5-16
1340486-3	1992	Considerable attention was given to the microheterogeneity of the transferrin molecule--the polymorphism, differences of the binding site for iron and possible donation of iron to the cell, number of carbohydrate antennae, degree of sialyzation--in connection to the possible link between microheterogeneity and physiological and pathophysiological status of the organism.	Iron	172-176	transferrin	Homo sapiens	66-77
1560730-3	1992	In the absence of L-arginine, IFN-gamma-induced infected cells can lower their net uptake of iron.	Iron	93-97	interferon gamma	Homo sapiens	30-39
1730572-0	1992	Thyroid hormone and apotransferrin regulation of growth hormone secretion by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium.	Iron	110-114	growth hormone 1	Rattus norvegicus	77-80
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Iron	67-71	growth hormone 1	Rattus norvegicus	34-37
1613823-2	1992	The iron-regulatory proteins transferrin and ferritin as well as iron are, in general, found predominantly in oligodendrocytes similar to that previously reported for normal brain tissue.	Iron	4-8	transferrin	Homo sapiens	29-40
1608289-3	1992	Exposure of the cells to anti-transferrin receptor antibody, 42/6, which blocks iron supplement into cells caused decreases of ribonucleotide reductase activity and DNA synthesis, in a parallel fashion.	Iron	80-84	transferrin	Homo sapiens	30-41
1543546-1	1992	Cell culture data have demonstrated that transferrin, the major iron (Fe) transport protein, is a necessary requirement for cellular proliferation.	Iron	64-68	transferrin	Homo sapiens	41-52
1635444-0	1992	[Acetylcholinesterase activity in erythrocytes of workers engaged in the production of iron-manganese alloys].	Iron	87-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	1-21
1635444-1	1992	The activity of acetylcholinesterase in the red blood cells of metallurgy workers producing iron-manganese alloys was statistically less significant than the activity of this enzyme in the control group.	Iron	92-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
1501748-0	1992	Possible mechanisms underlying potentiating effects of iron chelators in hematopoietic response to erythropoietin.	Iron	55-59	erythropoietin	Homo sapiens	99-113
1342713-4	1992	With the mounting evidence that TNF, IL-1, and T lymphocyte cytokines affect hemopoiesis and iron metabolism it is possible that the reported discrepancy is a reflection of that inextricable interdependence between the two systems in the face of infection.	Iron	93-97	tumor necrosis factor	Homo sapiens	32-35
1317533-0	1992	Recombinant human erythropoietin treatment reverses hepatic iron overload in hemodialysis patients.	Iron	60-64	erythropoietin	Homo sapiens	18-32
1543548-1	1992	One approach to creating a state of iron deprivation in tumors is to expose them to monoclonal antibodies against the transferrin receptor (ATRAs).	Iron	36-40	transferrin	Homo sapiens	118-129
1543546-2	1992	Evidence suggests that transferrin supports proliferation by providing Fe for critical cellular processes including DNA synthesis.	Iron	71-73	transferrin	Homo sapiens	23-34
1543546-3	1992	Lymphocytes, similar to other cell types, respond to an increased Fe requirement during proliferation by increased synthesis and expression of surface transferrin receptors.	Iron	66-68	transferrin	Homo sapiens	151-162
1543546-4	1992	Moreover, under transferrin-Fe-deplete conditions, certain lymphocyte lines exhibit other specialized adaptations that allow for sufficient Fe uptake to support cellular proliferation.	Iron	28-30	transferrin	Homo sapiens	16-27
1543546-4	1992	Moreover, under transferrin-Fe-deplete conditions, certain lymphocyte lines exhibit other specialized adaptations that allow for sufficient Fe uptake to support cellular proliferation.	Iron	140-142	transferrin	Homo sapiens	16-27
1543546-5	1992	These other adaptations include specialized transferrin synthesis and utilization of a transferrin-independent Fe uptake pathway.	Iron	111-113	transferrin	Homo sapiens	87-98
1543546-6	1992	Lymphocyte proliferation is inhibited by agents that interfere with cellular Fe metabolism; these agents include Fe chelators, class 3a metals that bind to transferrin, and antibodies directed against the transferrin receptor.	Iron	77-79	transferrin	Homo sapiens	205-216
1543546-7	1992	The data presented in this paper, demonstrate that differences in sensitivity to the effects of these agents are influenced by the amount of available transferrin-Fe and differences in the mechanisms that individual lymphocyte cell lines utilize to ensure adequate Fe uptake to support proliferation.	Iron	163-165	transferrin	Homo sapiens	151-162
1502136-12	1992	Expression of a high number of surface transferrin receptors in syncytiotrophoblast (1.5 x 10(12)/mg protein), along with a high affinity of these receptors for iron-saturated transferrin, could help explain the efficient transport of large amounts of iron from mother to fetus.	Iron	161-165	transferrin	Homo sapiens	176-187
1546369-2	1992	Tf-Gel-1 was developed by continuous exposure of HL-60 cells to human iron-saturated transferrin covalently linked to the plant toxin gelonin (Tf-Gel); this variant was five- to sixfold more resistant to Tf-Gel than parental HL-60 cells.	Iron	70-74	transferrin	Homo sapiens	85-96
1502136-12	1992	Expression of a high number of surface transferrin receptors in syncytiotrophoblast (1.5 x 10(12)/mg protein), along with a high affinity of these receptors for iron-saturated transferrin, could help explain the efficient transport of large amounts of iron from mother to fetus.	Iron	252-256	transferrin	Homo sapiens	39-50
1502136-12	1992	Expression of a high number of surface transferrin receptors in syncytiotrophoblast (1.5 x 10(12)/mg protein), along with a high affinity of these receptors for iron-saturated transferrin, could help explain the efficient transport of large amounts of iron from mother to fetus.	Iron	252-256	transferrin	Homo sapiens	176-187
1359698-1	1992	The expression of the gene for the iron transport protein transferrin was found to be altered in preneoplastic and neoplastic lesions induced in the rat liver by N-nitrosomorpholine.	Iron	35-39	transferrin	Rattus norvegicus	58-69
1764475-3	1991	The NMR spectral comparison of paramagnetically shifted resonances with those of the well characterized horseradish peroxidase C, HRP(C), isoenzyme indicates that both cucumber peroxidases have a protohemin IX prosthetic group with proximal histidine coordinated to the heme iron.	Iron	275-279	peroxidase 2-like	Cucumis sativus	116-126
1662207-7	1991	The resonance Raman spectra of denatured cyanomyeloperoxidase are less complicated than those of native myeloperoxidase, which have been interpreted previously to suggest an iron chlorin chromophore.	Iron	174-178	myeloperoxidase	Homo sapiens	46-61
1802636-8	1991	S-EPO: the placebo group had significantly higher values than the iron treated group from the 27th week of gestation to one week post partum (p less than 0.01).	Iron	66-70	erythropoietin	Homo sapiens	2-5
1772785-0	1991	Iron metabolism in patients with the anaemia of end-stage renal disease during treatment with recombinant human erythropoietin.	Iron	0-4	erythropoietin	Homo sapiens	112-126
1761059-5	1991	Consequently, redimerization of fibronectin was completely prevented by deferoxamine, an iron chelator.	Iron	89-93	fibronectin 1	Homo sapiens	32-43
1756517-3	1991	Catalase significantly decreased quercetin-induced nuclear DNA damage only in the presence of iron and had no significant effect on lipid peroxidation.	Iron	94-98	catalase	Rattus norvegicus	0-8
1657959-0	1991	Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans.	Iron	55-59	interleukin 1 beta	Homo sapiens	0-18
1771947-5	1991	There was a significant correlation of faecal alpha-1-antitrypsin with CDAI, activity index van Hees, and with various laboratory parameters (ESR, CRP, serum alpha-1-antitrypsin, orosomucoid, albumin, iron, haematocrit, haemoglobin, leucocytes, and thrombocytes).	Iron	201-205	serpin family A member 1	Homo sapiens	46-65
1959858-5	1991	This indicates that, as already suggested by our previous data in experimental siderosis, iron maintains the ability to induce transferrin gene activity even when cellular iron content is significantly increased.	Iron	90-94	transferrin	Homo sapiens	127-138
1959858-6	1991	Transferrin receptor gene expression was found to respond in the same manner to any cause of iron-tissue load, regardless of the cause.	Iron	93-97	transferrin	Homo sapiens	0-11
1822339-1	1991	Normal human plasma does not contain low molecular mass iron because the iron-binding protein transferrin retains a considerable iron-binding capacity.	Iron	73-77	transferrin	Homo sapiens	94-105
1822339-1	1991	Normal human plasma does not contain low molecular mass iron because the iron-binding protein transferrin retains a considerable iron-binding capacity.	Iron	73-77	transferrin	Homo sapiens	94-105
1657959-5	1991	It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide.	Iron	187-191	interleukin 1 beta	Homo sapiens	25-34
1657959-5	1991	It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide.	Iron	242-246	interleukin 1 beta	Homo sapiens	25-34
1779704-1	1991	Fluorescence and non-enzymatic browning were observed in reactions between ascorbic acid (AH2) and amino acids (AA) as well as in reactions involving AH2 autoxidation and/or polymerization in the presence of trace amounts of adventitious iron (less than or equal to 10 microM).	Iron	238-242	zinc finger RANBP2-type containing 3	Homo sapiens	150-153
1800033-3	1991	The results showed that fraction V of bovine serum albumin (2 x 10(-4) mol/L), iron saturated human transferrin (400 micrograms/ml), insulin (1 U/ml), and cholesterol (20 micrograms/ml) were indispensible components for the growth of ANLL L-CFU.	Iron	79-83	transferrin	Homo sapiens	100-111
1687018-10	1991	These results suggest that ethylene glycol is oxidized to formaldehyde by an oxidant derived from H2O2 and nonheme iron, and that cytochrome P-450 may function to generate the H2O2 and to catalyze reduction of the nonheme iron.	Iron	222-226	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	130-146
1657933-2	1991	The complete polypeptide chain of rubrerythrin from the sulfate reducing bacterium Desulfovibrio vulgaris, strain Hildenborough NCIB 8303, was found by protein chemical techniques to consist of 191 residues and to have the amino acid sequence [sequence: see text] The C-terminal part of the protein (position 153----191) shows the typical sequence features of rubredoxin, a protein with a nonheme iron center also present in the same and other Desulfovibrio species.	Iron	397-401	rr	Desulfovibrio vulgaris str. Hildenborough	34-46
1657933-4	1991	After characterization of the C-terminal region, and in contrast to what could be expected from previously published spectroscopic analyses, the N-terminal region 1-152 of rubrerythrin appears to have no sequence similarity with the eukaryotic protein hemerythrin which is known to contain a binuclear iron center bound by 5 histidine ligands.	Iron	302-306	rr	Desulfovibrio vulgaris str. Hildenborough	172-184
1657933-6	1991	We suggest that at least one of the 3 histidine residues located in the rubredoxin-like center of rubrerythrin may be liganded to one iron atom of the hemerythrin-like center.	Iron	134-138	rr	Desulfovibrio vulgaris str. Hildenborough	98-110
1935794-12	1991	Conversely, the activity of ferrochelatase, the enzyme that incorporates iron into porphyrin to form heme molecule, decreased significantly, as did the total heme levels.	Iron	73-77	ferrochelatase	Rattus norvegicus	28-42
1791188-5	1991	Electrophoretically separated holo-rat transferrin and rat lung-derived growth factor displayed similar positive stains for iron.	Iron	124-128	transferrin	Rattus norvegicus	39-50
1937757-1	1991	Bordetella pertussis and Bordetella bronchiseptica were both able to grow in iron-deficient medium when supplemented with iron-saturated human lactoferrin or transferrin but not with human apotransferrin.	Iron	77-81	transferrin	Homo sapiens	158-169
1771036-0	1991	A new function for transferrin receptor in cellular iron uptake.	Iron	52-56	transferrin	Homo sapiens	19-30
1919575-0	1991	Transferrin and iron uptake by the brain: effects of altered iron status.	Iron	61-65	transferrin	Rattus norvegicus	0-11
1919575-5	1991	Both Tf and iron uptake were significantly greater in the iron-deficient rats than in their controls and lower in the iron-loaded rats than in the corresponding controls.	Iron	58-62	transferrin	Rattus norvegicus	5-7
1919575-5	1991	Both Tf and iron uptake were significantly greater in the iron-deficient rats than in their controls and lower in the iron-loaded rats than in the corresponding controls.	Iron	58-62	transferrin	Rattus norvegicus	5-7
1919575-8	1991	125I-Tf uptake by the brains of the iron-deficient rats increased very rapidly after injection of the labelled proteins, within 15 min reaching a plateau level which was maintained for at least 6 h. The uptake of 59Fe, however, increased rapidly for 1 h and then more slowly, and in terms of percentage of injected dose reached much higher values than did 125I-Tf uptake.	Iron	36-40	transferrin	Rattus norvegicus	5-7
1940460-0	1991	Growth of Vibrio vulnificus in serum from alcoholics: association with high transferrin iron saturation.	Iron	88-92	transferrin	Homo sapiens	76-87
1771036-1	1991	Transferrin receptors may facilitate the release of iron from transferrin at mildly acidic pH, possibly a key reaction in making iron available to cells and allowing transferrin to be recycled back to the cell surface for release from the cell.	Iron	52-56	transferrin	Homo sapiens	0-11
1771036-1	1991	Transferrin receptors may facilitate the release of iron from transferrin at mildly acidic pH, possibly a key reaction in making iron available to cells and allowing transferrin to be recycled back to the cell surface for release from the cell.	Iron	52-56	transferrin	Homo sapiens	62-73
1771036-1	1991	Transferrin receptors may facilitate the release of iron from transferrin at mildly acidic pH, possibly a key reaction in making iron available to cells and allowing transferrin to be recycled back to the cell surface for release from the cell.	Iron	52-56	transferrin	Homo sapiens	166-177
1771036-1	1991	Transferrin receptors may facilitate the release of iron from transferrin at mildly acidic pH, possibly a key reaction in making iron available to cells and allowing transferrin to be recycled back to the cell surface for release from the cell.	Iron	129-133	transferrin	Homo sapiens	0-11
1771036-1	1991	Transferrin receptors may facilitate the release of iron from transferrin at mildly acidic pH, possibly a key reaction in making iron available to cells and allowing transferrin to be recycled back to the cell surface for release from the cell.	Iron	129-133	transferrin	Homo sapiens	62-73
1771037-0	1991	Transferrin receptor regulation coordinates placental iron uptake with maternal stores.	Iron	54-58	transferrin	Homo sapiens	0-11
1771037-1	1991	Transferrin receptor expression in the placenta may be regulated by the level of transferrin iron in maternal serum.	Iron	93-97	transferrin	Homo sapiens	81-92
1657909-0	1991	Significance of the "Rieske" iron-sulfur protein for formation and function of the ubiquinol-oxidation pocket of mitochondrial cytochrome c reductase (bc1 complex).	Iron	29-33	cytochrome c, somatic	Homo sapiens	127-139
1659450-2	1991	We noted that in contrast to results with other hydroxyl radical detection systems, superoxide dismutase (SOD) often increased the amount of hydroxyl radical-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) produced by the reaction of hypoxanthine, xanthine oxidase and iron.	Iron	285-289	superoxide dismutase 1	Homo sapiens	84-104
1659450-2	1991	We noted that in contrast to results with other hydroxyl radical detection systems, superoxide dismutase (SOD) often increased the amount of hydroxyl radical-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) produced by the reaction of hypoxanthine, xanthine oxidase and iron.	Iron	285-289	superoxide dismutase 1	Homo sapiens	106-109
1657909-7	1991	The affinity of three preparations of cytochrome c reductase, the complete, the delipidated, and the iron-sulfur depleted enzyme for E-beta-methoxyacrylate-stilbene, was analyzed for different redox states of the catalytic centers of cytochrome c reductase.	Iron	101-105	cytochrome c, somatic	Homo sapiens	38-50
1657189-0	1991	Effects of calcium on hepatocyte iron uptake from transferrin, iron-pyrophosphate and iron-ascorbate.	Iron	33-37	transferrin	Homo sapiens	50-61
1657189-1	1991	Calcium stimulates hepatocyte iron uptake from transferrin, ferric-iron-pyrophosphate and ferrous-iron-ascorbate.	Iron	30-34	transferrin	Homo sapiens	47-58
1657189-4	1991	In the presence of calcium the rate of iron uptake of non-transferrin bound iron increases abruptly at approximate 17 degrees C and 27 degrees C and as assessed by Arrhenius plots, the activation energy is reduced in a calcium dependent manner at approx.	Iron	39-43	transferrin	Homo sapiens	58-69
1657189-4	1991	In the presence of calcium the rate of iron uptake of non-transferrin bound iron increases abruptly at approximate 17 degrees C and 27 degrees C and as assessed by Arrhenius plots, the activation energy is reduced in a calcium dependent manner at approx.	Iron	76-80	transferrin	Homo sapiens	58-69
1657189-5	1991	27 degrees C. At a similar temperature, i.e., between 25 degrees C and 28 degrees C, calcium increases the rates of cellular iron uptake from transferrin in a way that is not reflected in the rate of transferrin endocytosis.	Iron	125-129	transferrin	Homo sapiens	142-153
1911786-3	1991	At pH 7.4, iron removal by 0.05 M pyrophosphate from each form of monoferric transferrin complexed to the receptor is considerably slower than from the corresponding free monoferric transferrin.	Iron	11-15	transferrin	Homo sapiens	77-88
1911786-3	1991	At pH 7.4, iron removal by 0.05 M pyrophosphate from each form of monoferric transferrin complexed to the receptor is considerably slower than from the corresponding free monoferric transferrin.	Iron	11-15	transferrin	Homo sapiens	182-193
1911786-0	1991	Receptor-modulated iron release from transferrin: differential effects on N- and C-terminal sites.	Iron	19-23	transferrin	Homo sapiens	37-48
1911786-1	1991	Iron release to PPi from N- and C-terminal monoferric transferrins and their complexes with transferrin receptor has been studied at pH 7.4 and 5.6 in 0.05 M HEPES or MES/0.1 M NaCl/0.01 M CHAPS at 25 degrees C. The two sites exhibit kinetic heterogeneity in releasing iron.	Iron	0-4	transferrin	Homo sapiens	54-65
1911786-5	1991	The rate of iron release to 0.005 M pyrophosphate by the N-terminal species is substantially the same whether transferrin is free or bound to the receptor.	Iron	12-16	transferrin	Homo sapiens	110-121
1911786-7	1991	Urea/PAGE analysis of iron removal from free and receptor-complexed diferric transferrin at pH 5.6 reveals that its C-terminal site is also more labile in the complex, but its N-terminal site is more labile in free diferric transferrin.	Iron	22-26	transferrin	Homo sapiens	77-88
1911786-7	1991	Urea/PAGE analysis of iron removal from free and receptor-complexed diferric transferrin at pH 5.6 reveals that its C-terminal site is also more labile in the complex, but its N-terminal site is more labile in free diferric transferrin.	Iron	22-26	transferrin	Homo sapiens	224-235
1911786-8	1991	Thus, the newly discovered role of transferrin receptor in modulating iron release from transferrin predominantly involves the C-terminal site.	Iron	70-74	transferrin	Homo sapiens	35-46
1656994-9	1991	Thus, a combination of iron-chelating and iron ion-reducing properties appears to be required for selective 5-lipoxygenase inhibition by phenolic compounds.	Iron	23-27	arachidonate 5-lipoxygenase	Homo sapiens	108-122
1911786-8	1991	Thus, the newly discovered role of transferrin receptor in modulating iron release from transferrin predominantly involves the C-terminal site.	Iron	70-74	transferrin	Homo sapiens	88-99
1656994-9	1991	Thus, a combination of iron-chelating and iron ion-reducing properties appears to be required for selective 5-lipoxygenase inhibition by phenolic compounds.	Iron	42-46	arachidonate 5-lipoxygenase	Homo sapiens	108-122
1928080-7	1991	This suggests a possible interaction between body iron store status and the synthesis of Epo.	Iron	50-54	erythropoietin	Homo sapiens	89-92
1725170-2	1991	Apparent dissociation constants (Kd"s) have been determined for the binding of the antibodies to human transferrin in the presence and absence of iron.	Iron	146-150	transferrin	Homo sapiens	103-114
1930142-6	1991	The distances of the protons of bound tyrosine molecules from the haem iron atoms of HRP and LPO indicate that the site of binding of these substrates is the same as that of simple phenols.	Iron	71-75	lactoperoxidase	Homo sapiens	93-96
1742921-0	1991	The effect of human recombinant erythropoietin on iron absorption and hepatic iron in a rat model.	Iron	50-54	erythropoietin	Homo sapiens	32-46
1742921-1	1991	In order to ascertain whether recombinant human erythropoietin (EPO) therapy would result in further intestinal iron absorption in the setting of systemic iron loading, iron absorption was measured in iron-loaded rats receiving EPO therapy and a control group of iron-loaded rats.	Iron	112-116	erythropoietin	Homo sapiens	48-62
1742921-1	1991	In order to ascertain whether recombinant human erythropoietin (EPO) therapy would result in further intestinal iron absorption in the setting of systemic iron loading, iron absorption was measured in iron-loaded rats receiving EPO therapy and a control group of iron-loaded rats.	Iron	112-116	erythropoietin	Homo sapiens	64-67
1953090-1	1991	Epoetin alfa: focus on oral iron supplementation.	Iron	28-32	erythropoietin	Homo sapiens	0-7
1953090-2	1991	Iron is an essential component of Epoetin alfa-supported erythropoiesis, and virtually all patients receiving this medication will eventually require iron supplementation.	Iron	0-4	erythropoietin	Homo sapiens	34-41
1833093-0	1991	Atrial natriuretic peptide assayed after immunoextraction with magnetic iron particles.	Iron	72-76	natriuretic peptide A	Homo sapiens	0-26
1833093-2	1991	Anti-ANP antibody was coupled to magnetizable iron particles by various coupling methods; both carboxyl terminal and amine terminal iron particles were examined.	Iron	46-50	natriuretic peptide A	Homo sapiens	5-8
1833093-3	1991	Introducing a chemical spacer between the iron particles and the antibody improved binding with ANP.	Iron	42-46	natriuretic peptide A	Homo sapiens	96-99
1960147-5	1991	Specific scavenging of free radical activity by the enzymes catalase and superoxide dismutase, the hydroxyl radical inhibitors dimethyl sulfoxide and dimethylthiourea (DMTU) and by chelation of intracellular free iron with deferoxamine produced only a partial restoration of [3H]thymidine incorporation into DNA, which was maximal for DMTU (30% of normal incorporation).	Iron	213-217	catalase	Rattus norvegicus	60-68
1791467-3	1991	After 24 hours incubation at a 40:1 chelator:protein molar ratio, the percentage of iron removed from Fe(III)-ovotransferrin is 50%-60%, and is somewhat higher in the case of serum transferrin, in line with the respective affinity constants for the metal.	Iron	84-88	transferrin	Homo sapiens	113-124
1918366-3	1991	In previous studies, we have demonstrated that L. pneumophila intracellular multiplication in human monocytes is iron dependent and that IFN gamma-activated monocytes inhibit L. pneumophila intracellular multiplication by limiting the availability of iron.	Iron	251-255	interferon gamma	Homo sapiens	137-146
1918366-9	1991	Similarly, the nonphysiologic iron chelates ferric nitrilotriacetate and ferric ammonium citrate completely reverse and ferric pyrophosphate partially reversed the capacity of IFN gamma-activated monocytes to inhibit L. pneumophila intracellular multiplication, demonstrating that L. pneumophila can utilize iron derived from nonphysiologic iron chelates internalized by monocytes independently of the transferrin and lactoferrin endocytic pathways.	Iron	30-34	interferon gamma	Homo sapiens	176-185
1918366-9	1991	Similarly, the nonphysiologic iron chelates ferric nitrilotriacetate and ferric ammonium citrate completely reverse and ferric pyrophosphate partially reversed the capacity of IFN gamma-activated monocytes to inhibit L. pneumophila intracellular multiplication, demonstrating that L. pneumophila can utilize iron derived from nonphysiologic iron chelates internalized by monocytes independently of the transferrin and lactoferrin endocytic pathways.	Iron	308-312	interferon gamma	Homo sapiens	176-185
1918366-9	1991	Similarly, the nonphysiologic iron chelates ferric nitrilotriacetate and ferric ammonium citrate completely reverse and ferric pyrophosphate partially reversed the capacity of IFN gamma-activated monocytes to inhibit L. pneumophila intracellular multiplication, demonstrating that L. pneumophila can utilize iron derived from nonphysiologic iron chelates internalized by monocytes independently of the transferrin and lactoferrin endocytic pathways.	Iron	308-312	interferon gamma	Homo sapiens	176-185
1791467-2	1991	The kinetics of iron removal by 3-hydroxypyridin-4-ones from both transferrins is slow; in ovotransferrin it appears to be monophasic, in contrast to that observed for serum transferrin.	Iron	16-20	transferrin	Homo sapiens	66-77
1791467-6	1991	The degree of transferrin saturation influences the extent of chelator mediated iron mobilization in the case of serum transferrin, but not of ovotransferrin.	Iron	80-84	transferrin	Homo sapiens	14-25
1791467-6	1991	The degree of transferrin saturation influences the extent of chelator mediated iron mobilization in the case of serum transferrin, but not of ovotransferrin.	Iron	80-84	transferrin	Homo sapiens	119-130
1806447-6	1991	Non-transferrin bound iron, i.e. iron that circulates in plasma unbound to transferrin, is potentially toxic since it is capable of taking part in free radical-mediated reactions that result in irreversible tissue damage.	Iron	22-26	transferrin	Homo sapiens	4-15
1894645-1	1991	The function of the transferrin receptor is to transport iron-bound transferrin into the cell.	Iron	57-61	transferrin	Homo sapiens	20-31
1894645-1	1991	The function of the transferrin receptor is to transport iron-bound transferrin into the cell.	Iron	57-61	transferrin	Homo sapiens	68-79
1889413-0	1991	Identification and characterization of a Saccharomyces cerevisiae gene (PAR1) conferring resistance to iron chelators.	Iron	103-107	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	72-76
1654090-0	1991	Iron binding to horse spleen apoferritin: a vanadyl ENDOR spin probe study.	Iron	0-4	ferritin heavy chain	Equus caballus	29-40
1884019-0	1991	Transferrin-independent iron uptake supports B lymphocyte growth.	Iron	24-28	transferrin	Homo sapiens	0-11
1776464-0	1991	Transferrin receptors and selective iron deposition in pancreatic B cells of iron-overloaded rats.	Iron	77-81	transferrin	Rattus norvegicus	0-11
1654860-6	1991	Since the uptake of 59Fe-transferrin is greatly inhibited by the treatment of HL60 cells with CuL, the reduced uptake of iron by cells, in the presence of CuL, may lead to decreased iron availability for the activity of the M2 subunit of ribonucleotide reductase and a subsequent decrease in the tyrosyl radical signal of the enzyme.	Iron	121-125	transferrin	Homo sapiens	25-36
1654860-6	1991	Since the uptake of 59Fe-transferrin is greatly inhibited by the treatment of HL60 cells with CuL, the reduced uptake of iron by cells, in the presence of CuL, may lead to decreased iron availability for the activity of the M2 subunit of ribonucleotide reductase and a subsequent decrease in the tyrosyl radical signal of the enzyme.	Iron	182-186	transferrin	Homo sapiens	25-36
1889413-7	1991	Plasmid-directed overexpression of PAR1 increased the resistance of transformants to o-phenanthroline and additionally conferred resistance to 1-nitroso-2-naphthol, an iron(III)-binding molecule with different coordinating ligands.	Iron	168-172	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	35-39
1889413-9	1991	These observations clearly demonstrated that the overexpressed PAR1 gene enables the cell to compete with iron-chelating organic molecules.	Iron	106-110	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	63-67
1806447-6	1991	Non-transferrin bound iron, i.e. iron that circulates in plasma unbound to transferrin, is potentially toxic since it is capable of taking part in free radical-mediated reactions that result in irreversible tissue damage.	Iron	22-26	transferrin	Homo sapiens	75-86
1806447-6	1991	Non-transferrin bound iron, i.e. iron that circulates in plasma unbound to transferrin, is potentially toxic since it is capable of taking part in free radical-mediated reactions that result in irreversible tissue damage.	Iron	33-37	transferrin	Homo sapiens	4-15
1806447-6	1991	Non-transferrin bound iron, i.e. iron that circulates in plasma unbound to transferrin, is potentially toxic since it is capable of taking part in free radical-mediated reactions that result in irreversible tissue damage.	Iron	33-37	transferrin	Homo sapiens	75-86
1919301-0	1991	Iron-restricted erythropoiesis as a limitation to autologous blood donation in the erythropoietin-stimulated bone marrow.	Iron	0-4	erythropoietin	Homo sapiens	83-97
1655849-1	1991	This study describes the effect of transferrin as an iron source on the growth of Porphyromonas (formally Bacteroides) gingivalis.	Iron	53-57	transferrin	Homo sapiens	35-46
1655849-8	1991	These results suggest that P. gingivalis may be capable of utilizing transferrin as an iron source for growth in vivo.	Iron	87-91	transferrin	Homo sapiens	69-80
1831796-0	1991	Relative availability of transferrin-bound iron and cell-derived iron to aerobactin-producing and enterochelin-producing strains of Escherichia coli and to other microorganisms.	Iron	43-47	transferrin	Homo sapiens	25-36
1831796-1	1991	A method is described for determination of the relative availability of transferrin-bound iron and cell-derived iron to microbial iron-scavenging mechanisms.	Iron	90-94	transferrin	Homo sapiens	72-83
1831796-2	1991	This involved incubation of parallel cultures of microorganisms in dialysis tubes placed in RPMI 1640 tissue culture medium containing 30%-iron-saturated transferrin and K562 erythroleukemia cells.	Iron	139-143	transferrin	Homo sapiens	154-165
1669632-2	1991	However in vivo iron is complexed with host proteins such as transferrin in the blood and lactoferrin in secretions so that it is not available as a free ionic iron.	Iron	16-20	transferrin	Homo sapiens	61-72
1788107-0	1991	[Influence of iron metabolism on the efficacy of r-HuEPO (recombinant human erythropoietin) treatment of anemia in children on hemodialysis].	Iron	14-18	erythropoietin	Homo sapiens	76-90
1878368-5	1991	But also at lowered temperature only a part of the iron in endosomal fractions can be assigned to transferrin.	Iron	51-55	transferrin	Rattus norvegicus	98-109
1878368-6	1991	A considerable part of the total uptake of transferrin and iron can be attributed to low-affinity mechanisms even at very low transferrin concentrations.	Iron	59-63	transferrin	Rattus norvegicus	126-137
1909528-0	1991	Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro.	Iron	54-58	aldo-keto reductase family 1 member B	Homo sapiens	29-45
1715280-0	1991	Iron entry route in horse spleen apoferritin.	Iron	0-4	ferritin heavy chain	Equus caballus	33-44
1858781-3	1991	A significant inverse relationship was observed for the relationship between the expression of transferrin receptor on monocytes and log(hepatic iron concentration) in hemochromatosis patients (r = -0.59, P less than .02) and also for the relationship between the expression of transferrin receptor and log(serum ferritin) in normal volunteers (r = -0.90, P less than .001).	Iron	145-149	transferrin	Homo sapiens	95-106
1873300-3	1991	The generation of H2O2 and reduction of Fe-complex were mainly dependent on the activity of NADH: menadione oxidoreductase in the plasma membrane and cytosol fractions.	Iron	40-42	oxidoreductase	Saccharomyces cerevisiae S288C	108-122
1782724-0	1991	Oral iron absorption in hemodialysis patients treated with erythropoietin.	Iron	5-9	erythropoietin	Homo sapiens	59-73
1872645-0	1991	Back to the basics in iron management for the patient receiving epoetin therapy.	Iron	22-26	erythropoietin	Homo sapiens	64-71
1863821-5	1991	When the Hb fell to 10 g/dl or less, the serum Epo of 13 RD patients with ferritin less than 20 micrograms/l was 65 (47,89)mU/ml, significantly lower (P less than 0.05) than that of 17 iron deficient controls (104 (78,136)mU/ml).	Iron	185-189	erythropoietin	Homo sapiens	47-50
1782724-11	1991	The high level of iron stores (i.e., ferritin) present in the Canadian EPO study patients may prevent an effect of the erythropoietic stimulation on iron absorption.	Iron	18-22	erythropoietin	Homo sapiens	71-74
1782724-11	1991	The high level of iron stores (i.e., ferritin) present in the Canadian EPO study patients may prevent an effect of the erythropoietic stimulation on iron absorption.	Iron	149-153	erythropoietin	Homo sapiens	71-74
1782724-12	1991	Although an increase in iron absorption by EPO was not demonstrated, a type II error could not be excluded.	Iron	24-28	erythropoietin	Homo sapiens	43-46
1873229-5	1991	Manipulating iron supply by adding iron chelators or diferric transferrin to the incubation medium produced marked alterations in cellular receptor and ferritin content.	Iron	13-17	transferrin	Homo sapiens	62-73
1889482-6	1991	Cellular proliferative activity increases the expression of transferrin receptor and could modulate the biosynthesis of intracellular ferritin that is normally controlled by iron.	Iron	174-178	transferrin	Homo sapiens	60-71
1908818-0	1991	Association between Rh and plasma iron binding (transferrin).	Iron	34-38	transferrin	Homo sapiens	48-59
1908818-4	1991	Highly significant results were found for Rh phenotypes and total iron binding capacity (TIBC, transferrin).	Iron	66-70	transferrin	Homo sapiens	95-106
1856222-2	1991	It has been suggested recently that modulation of TfR and ferritin synthesis by iron is mediated through a cytoplasmic protein(s) (iron regulatory element-binding protein(s) (IRE-BP)), which interacts with ferritin and TfR mRNA at the level of hairpin structures (IRE), thus leading to inhibition of transferrin mRNA degradation and repression of ferritin mRNA translation.	Iron	80-84	transferrin	Homo sapiens	300-311
1654818-6	1991	These results show that reaction of cytochrome c with H2O2 promotes membrane oxidation by more than one chemical mechanism, including formation of high oxidation states of iron at the cytochrome-heme and also by heme iron release at higher H2O2 concentrations.	Iron	172-176	cytochrome c, somatic	Homo sapiens	36-48
1654818-6	1991	These results show that reaction of cytochrome c with H2O2 promotes membrane oxidation by more than one chemical mechanism, including formation of high oxidation states of iron at the cytochrome-heme and also by heme iron release at higher H2O2 concentrations.	Iron	217-221	cytochrome c, somatic	Homo sapiens	36-48
1676967-6	1991	All three isozymes were rapidly activated (13-40-fold) by incubation with Fe(II) salts (concentration of iron at half-maximal activation = 6-14 microM), and were inhibited by other divalent metal ions, e.g. Zn(II), Co(II) and Ni(II).	Iron	105-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
2050125-0	1991	Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.	Iron	87-91	5'-aminolevulinate synthase 1	Homo sapiens	16-42
1649718-0	1991	Hepatic computed tomography for monitoring the iron status of haemodialysis patients with haemosiderosis treated with recombinant human erythropoietin.	Iron	47-51	erythropoietin	Homo sapiens	136-150
2050125-7	1991	An iron-responsive element (IRE) motif has been identified in the 5"-untranslated region of the human erythroid ALAS mRNA, but is not present in the housekeeping ALAS mRNA.	Iron	3-7	5'-aminolevulinate synthase 1	Homo sapiens	112-116
2050125-10	1991	These results suggest that the IRE motif in the ALAS mRNA is functional and imply that translation of the mRNA is controlled by cellular iron availability during erythropoiesis.	Iron	137-141	5'-aminolevulinate synthase 1	Homo sapiens	48-52
2065674-1	1991	A study was made on the uptake of iron by horse spleen apoferritin, by using as an iron source the same ferric dihydrolipoate complex which represents the major product in the anaerobic removal of ferritin-bound iron by dihydrolipoate at neutral pH.	Iron	83-87	ferritin heavy chain	Equus caballus	55-66
2050126-3	1991	Iron starvation of cells induces high affinity binding of the cytoplasmic IRE-BP to an IRE which has at least two different known biological consequences, repression of ferritin mRNA translation and stabilization of the transferrin receptor transcript.	Iron	0-4	transferrin	Homo sapiens	220-231
2065674-1	1991	A study was made on the uptake of iron by horse spleen apoferritin, by using as an iron source the same ferric dihydrolipoate complex which represents the major product in the anaerobic removal of ferritin-bound iron by dihydrolipoate at neutral pH.	Iron	34-38	ferritin heavy chain	Equus caballus	55-66
2065674-1	1991	A study was made on the uptake of iron by horse spleen apoferritin, by using as an iron source the same ferric dihydrolipoate complex which represents the major product in the anaerobic removal of ferritin-bound iron by dihydrolipoate at neutral pH.	Iron	83-87	ferritin heavy chain	Equus caballus	55-66
1889892-0	1991	Combined recombinant human erythropoietin-blood letting strategy for treating anemia and iron overload in hemodialysis patients.	Iron	89-93	erythropoietin	Homo sapiens	27-41
1904840-4	1991	We tested whether the antihistoplasma effect of IFN-gamma-treated macrophages is the result of iron deprivation.	Iron	95-99	interferon gamma	Mus musculus	48-57
1904840-7	1991	These results suggest that iron restriction may be one of the bases for the IFN-gamma-induced antihistoplasma effect of mouse macrophages.	Iron	27-31	interferon gamma	Mus musculus	76-85
1839048-0	1991	Evidence for non-siderophore-mediated acquisition of transferrin-bound iron by Pasteurella multocida.	Iron	71-75	serotransferrin	Bos taurus	53-64
1839048-3	1991	This correlated with specific binding of bovine transferrin by iron-limited cells or isolated membranes.	Iron	63-67	serotransferrin	Bos taurus	48-59
1839048-5	1991	In response to iron-limited conditions, a number of high molecular mass iron-regulated outer membrane proteins were produced including an 82 kDa receptor protein which was affinity isolated with biotinylated transferrin.	Iron	15-19	serotransferrin	Bos taurus	208-219
1839048-5	1991	In response to iron-limited conditions, a number of high molecular mass iron-regulated outer membrane proteins were produced including an 82 kDa receptor protein which was affinity isolated with biotinylated transferrin.	Iron	72-76	serotransferrin	Bos taurus	208-219
1919507-0	1991	Isolation and characterization of a mutant of Neisseria gonorrhoeae that is defective in the uptake of iron from transferrin and haemoglobin and is avirulent in mouse subcutaneous chambers.	Iron	103-107	transferrin	Homo sapiens	113-124
1920844-0	1991	[Treatment of iron overload with combination of recombinant human erythropoietin and phlebotomy].	Iron	14-18	erythropoietin	Homo sapiens	66-80
1920844-3	1991	To treat iron overload, we administered recombinant human erythropoietin (Epo) in combination with phlebotomy.	Iron	9-13	erythropoietin	Homo sapiens	58-72
1920844-4	1991	Total iron removed for 5 months was about 4 g. Thus, combination of Epo and phlebotomy was effective for the treatment of iron overload disease.	Iron	6-10	erythropoietin	Homo sapiens	68-71
1646718-0	1991	EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors.	Iron	57-61	phenylalanine hydroxylase	Bos taurus	84-109
1646718-1	1991	The paramagnetic iron at the active site of highly purified, catalytically active phenylalanine hydroxylase was studied by EPR at 3.6 K and one-dimensional 1H-NMR spectroscopy at 293 K. The EPR-detectable iron of the bovine enzyme was found to be present as a high-spin form (S = 5/2) in different ligand field symmetries depending on medium conditions (buffer ions) and the presence of ligands known to bind at the active site.	Iron	17-21	phenylalanine hydroxylase	Bos taurus	82-107
1646718-1	1991	The paramagnetic iron at the active site of highly purified, catalytically active phenylalanine hydroxylase was studied by EPR at 3.6 K and one-dimensional 1H-NMR spectroscopy at 293 K. The EPR-detectable iron of the bovine enzyme was found to be present as a high-spin form (S = 5/2) in different ligand field symmetries depending on medium conditions (buffer ions) and the presence of ligands known to bind at the active site.	Iron	205-209	phenylalanine hydroxylase	Bos taurus	82-107
1918252-1	1991	A simple method for the chromatographic separation of the different molecular forms of human transferrin according to their respective iron contents is described.	Iron	135-139	transferrin	Homo sapiens	93-104
1669091-0	1991	[Activity of glucose-6-phosphate dehydrogenase in erythrocytes of workers at the smelting works plant for manufacture of iron and manganese alloys].	Iron	121-125	glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform	Nicotiana tabacum	13-46
2037564-0	1991	Human 5-lipoxygenase contains an essential iron.	Iron	43-47	arachidonate 5-lipoxygenase	Homo sapiens	6-20
2037564-1	1991	The iron content of human 5-lipoxygenase has been determined by a colorimetric assay using the chromogenic ligand FerroZine.	Iron	4-8	arachidonate 5-lipoxygenase	Homo sapiens	26-40
2039817-0	1991	Iron uptake by human reticulocytes at physiologic and sub-physiologic concentrations of iron transferrin: the effect of interaction with aluminum transferrin.	Iron	0-4	transferrin	Homo sapiens	93-104
2039817-0	1991	Iron uptake by human reticulocytes at physiologic and sub-physiologic concentrations of iron transferrin: the effect of interaction with aluminum transferrin.	Iron	0-4	transferrin	Homo sapiens	146-157
2039817-8	1991	Interpreted in terms of a current conventional view of metallo-transferrin uptake, we conjecture that the early parallel processes involve cell surface phenomena including classical transferrin-receptor binding, and that the subsequent process represents events, possibly intracellular, involved in metallo-transferrin dissociation or further iron transport.	Iron	343-347	transferrin	Homo sapiens	63-74
1711842-1	1991	Extrahepatic synthesis and secretion of transferrin (Tf), the major iron-carrying protein, have been described in normal and tumoral tissues suggesting a potential role for paracrine or autocrine function.	Iron	68-72	transferrin	Homo sapiens	40-51
1711842-1	1991	Extrahepatic synthesis and secretion of transferrin (Tf), the major iron-carrying protein, have been described in normal and tumoral tissues suggesting a potential role for paracrine or autocrine function.	Iron	68-72	transferrin	Homo sapiens	53-55
1747454-0	1991	Iron balance following recombinant human erythropoietin therapy for anemia associated with chronic renal failure.	Iron	0-4	erythropoietin	Homo sapiens	41-55
1747455-1	1991	Transferrin (Tf) was found immunologically in pancreatic juice of normal rats at a concentration of 0.28 +/- 0.10 mg/ml but was found to be approximately 4-times higher in iron-deficient rats.	Iron	172-176	transferrin	Rattus norvegicus	0-11
1747455-1	1991	Transferrin (Tf) was found immunologically in pancreatic juice of normal rats at a concentration of 0.28 +/- 0.10 mg/ml but was found to be approximately 4-times higher in iron-deficient rats.	Iron	172-176	transferrin	Rattus norvegicus	13-15
1747455-2	1991	Iron saturation of pancreatic Tf of normal rats was 40% and similar to that of serum Tf.	Iron	0-4	transferrin	Rattus norvegicus	30-32
1747455-3	1991	Approximately 27% of a dose of iron from 59Fe-diferric Tf was absorbed through the ligated segments of proximal intestine in normal rats.	Iron	31-35	transferrin	Rattus norvegicus	55-57
1747455-4	1991	The iron absorption ratio of 59Fe-diferric Tf was higher from the duodenal and jejunal segments than the ileum and significantly inhibited by monodansylcadaverine (MDC) or 20-times excess of unlabeled diferric Tf.	Iron	4-8	transferrin	Rattus norvegicus	43-45
1747455-4	1991	The iron absorption ratio of 59Fe-diferric Tf was higher from the duodenal and jejunal segments than the ileum and significantly inhibited by monodansylcadaverine (MDC) or 20-times excess of unlabeled diferric Tf.	Iron	4-8	transferrin	Rattus norvegicus	210-212
1747455-9	1991	These results suggested that some iron was absorbed as diferric Tf into enterocytes through receptor-mediated endocytosis.	Iron	34-38	transferrin	Rattus norvegicus	64-66
1890732-3	1991	Both Tf and TfR are reutilizable and have roles for the efficient intracellular accumulation of iron.	Iron	96-100	transferrin	Homo sapiens	5-7
1662302-2	1991	The c-fos-immunopositive neurons were observed in a hippocampal formation, especially in the dentate gyrus and CA1 and CA2, in the vicinity of the iron injected cerebral cortex and amygdala only at 3 hours after the iron administration.	Iron	147-151	carbonic anhydrase 2	Rattus norvegicus	119-122
2052577-9	1991	Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl.	Iron	204-208	tumor necrosis factor	Homo sapiens	137-146
2052577-9	1991	Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl.	Iron	204-208	tumor necrosis factor	Homo sapiens	137-146
2052577-10	1991	Finally, we observed that the TNF-alpha-mediated increase in ferritin synthesis peaked at 8 hr and was followed by a decrease in both H and L isoferritin synthesis; the addition of iron, however, reversed the late-occurring depression in ferritin synthesis.	Iron	181-185	tumor necrosis factor	Homo sapiens	30-39
2052577-11	1991	This suggests that TNF-alpha-induced synthesis of H-rich ferritin may reduce the regulatory pool of intracellular iron, secondarily inhibiting iron-mediated translation of ferritin mRNA.	Iron	114-118	tumor necrosis factor	Homo sapiens	19-28
2052577-11	1991	This suggests that TNF-alpha-induced synthesis of H-rich ferritin may reduce the regulatory pool of intracellular iron, secondarily inhibiting iron-mediated translation of ferritin mRNA.	Iron	143-147	tumor necrosis factor	Homo sapiens	19-28
2052577-12	1991	We conclude that TNF-alpha acts independently of iron in its induction of ferritin H mRNA but requires the presence of iron for this effect to be fully expressed at the protein level.	Iron	49-53	tumor necrosis factor	Homo sapiens	17-26
2052577-12	1991	We conclude that TNF-alpha acts independently of iron in its induction of ferritin H mRNA but requires the presence of iron for this effect to be fully expressed at the protein level.	Iron	119-123	tumor necrosis factor	Homo sapiens	17-26
2052577-0	1991	Iron-independent induction of ferritin H chain by tumor necrosis factor.	Iron	0-4	ferritin mitochondrial	Mus musculus	30-40
2052577-3	1991	Using primary human myoblasts, we have now examined the relationship between TNF-alpha and iron in regulating ferritin.	Iron	91-95	tumor necrosis factor	Homo sapiens	77-86
2052577-6	1991	Second, the increase in ferritin H protein synthesis observed during TNF-alpha treatment was dependent on an increase in ferritin H mRNA: actinomycin D blocked the TNF-alpha-induced changes in ferritin H but did not inhibit the translational induction of ferritin seen with iron treatment.	Iron	274-278	ferritin mitochondrial	Mus musculus	24-34
2052577-6	1991	Second, the increase in ferritin H protein synthesis observed during TNF-alpha treatment was dependent on an increase in ferritin H mRNA: actinomycin D blocked the TNF-alpha-induced changes in ferritin H but did not inhibit the translational induction of ferritin seen with iron treatment.	Iron	274-278	tumor necrosis factor	Homo sapiens	69-78
2052577-6	1991	Second, the increase in ferritin H protein synthesis observed during TNF-alpha treatment was dependent on an increase in ferritin H mRNA: actinomycin D blocked the TNF-alpha-induced changes in ferritin H but did not inhibit the translational induction of ferritin seen with iron treatment.	Iron	274-278	ferritin mitochondrial	Mus musculus	121-131
2052577-6	1991	Second, the increase in ferritin H protein synthesis observed during TNF-alpha treatment was dependent on an increase in ferritin H mRNA: actinomycin D blocked the TNF-alpha-induced changes in ferritin H but did not inhibit the translational induction of ferritin seen with iron treatment.	Iron	274-278	tumor necrosis factor	Homo sapiens	164-173
2052577-6	1991	Second, the increase in ferritin H protein synthesis observed during TNF-alpha treatment was dependent on an increase in ferritin H mRNA: actinomycin D blocked the TNF-alpha-induced changes in ferritin H but did not inhibit the translational induction of ferritin seen with iron treatment.	Iron	274-278	ferritin mitochondrial	Mus musculus	121-131
2052577-8	1991	Fourth, ferritin H induction by TNF-alpha and iron was additive over the entire range of iron concentrations, even at TNF-alpha doses known to maximally stimulate ferritin H mRNA levels.	Iron	46-50	ferritin mitochondrial	Mus musculus	8-18
2052577-8	1991	Fourth, ferritin H induction by TNF-alpha and iron was additive over the entire range of iron concentrations, even at TNF-alpha doses known to maximally stimulate ferritin H mRNA levels.	Iron	89-93	ferritin mitochondrial	Mus musculus	8-18
2052577-8	1991	Fourth, ferritin H induction by TNF-alpha and iron was additive over the entire range of iron concentrations, even at TNF-alpha doses known to maximally stimulate ferritin H mRNA levels.	Iron	89-93	tumor necrosis factor	Homo sapiens	32-41
2052577-9	1991	Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl.	Iron	25-29	tumor necrosis factor	Homo sapiens	86-95
1828435-2	1991	Aeromonas isolated producing the siderophore amonabactin obtain iron either from host Fe-transferrin (siderophore dependent) or from host heme-containing molecules (siderophore independent).	Iron	64-68	transferrin	Homo sapiens	89-100
2052577-9	1991	Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl.	Iron	25-29	tumor necrosis factor	Homo sapiens	137-146
1887567-7	1991	Cells expressing the IROMPs or its OMP extracts grown in iron-restricted media also showed greater binding to 59Fe-pasteurella siderophore (multocidin) when compared to bacteria or its extracts not expressing IROMPs.	Iron	57-61	TolC family protein	Pasteurella multocida	23-26
1646028-1	1991	Molecular dynamics simulations of a tetraheme cytochrome c3 were performed to investigate dynamic aspects of the motion of the axial heme iron ligands.	Iron	138-142	cytochrome c, somatic	Homo sapiens	46-58
2022630-8	1991	The results suggest that the Tf receptor, in addition to providing a means by which cells may internalize Tf, functions to increase the release of iron from Tf in the endosome.	Iron	147-151	transferrin	Homo sapiens	106-108
1850741-2	1991	Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of their potency by reducing the lipoxygenase active-site iron from the active ferric state to the inactive ferrous state.	Iron	247-251	seed linoleate 13S-lipoxygenase-1	Glycine max	14-28
2039523-1	1991	Reduction of iron in diferric transferrin is inhibited by monoclonal antibodies to the transferrin receptor which bind at sites other than the high affinity transferrin binding site.	Iron	13-17	transferrin	Homo sapiens	30-41
2039523-1	1991	Reduction of iron in diferric transferrin is inhibited by monoclonal antibodies to the transferrin receptor which bind at sites other than the high affinity transferrin binding site.	Iron	13-17	transferrin	Homo sapiens	87-98
2039523-1	1991	Reduction of iron in diferric transferrin is inhibited by monoclonal antibodies to the transferrin receptor which bind at sites other than the high affinity transferrin binding site.	Iron	13-17	transferrin	Homo sapiens	87-98
2022630-0	1991	Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH.	Iron	51-55	transferrin	Homo sapiens	69-80
2022630-1	1991	In order to better understand the cellular delivery of iron from serum transferrin (Tf), we compared iron release from receptor-bound and free Tf.	Iron	55-59	transferrin	Homo sapiens	71-82
2022630-1	1991	In order to better understand the cellular delivery of iron from serum transferrin (Tf), we compared iron release from receptor-bound and free Tf.	Iron	55-59	transferrin	Homo sapiens	84-86
2022630-2	1991	While free Tf did not release all iron until below pH 4.6, receptor-bound Tf released significantly more iron at mildly acidic pH, with essentially all iron released between pH 5.6 and 6.0.	Iron	105-109	transferrin	Homo sapiens	74-76
2022630-2	1991	While free Tf did not release all iron until below pH 4.6, receptor-bound Tf released significantly more iron at mildly acidic pH, with essentially all iron released between pH 5.6 and 6.0.	Iron	105-109	transferrin	Homo sapiens	74-76
2022630-3	1991	Since Tf is acidified to a minimum pH of 5.4 in K562 cells, this result accounts for the nearly complete extraction of iron from Tf by these cells.	Iron	119-123	transferrin	Homo sapiens	6-8
2022630-3	1991	Since Tf is acidified to a minimum pH of 5.4 in K562 cells, this result accounts for the nearly complete extraction of iron from Tf by these cells.	Iron	119-123	transferrin	Homo sapiens	129-131
2022630-6	1991	Binding to the Tf receptor, while facilitating iron release from Tf, appears to partially inhibit a conformational change that causes the increase in LRSC-Tf fluorescence at low pH.	Iron	47-51	transferrin	Homo sapiens	15-17
2022630-6	1991	Binding to the Tf receptor, while facilitating iron release from Tf, appears to partially inhibit a conformational change that causes the increase in LRSC-Tf fluorescence at low pH.	Iron	47-51	transferrin	Homo sapiens	65-67
2022630-8	1991	The results suggest that the Tf receptor, in addition to providing a means by which cells may internalize Tf, functions to increase the release of iron from Tf in the endosome.	Iron	147-151	transferrin	Homo sapiens	106-108
2022630-8	1991	The results suggest that the Tf receptor, in addition to providing a means by which cells may internalize Tf, functions to increase the release of iron from Tf in the endosome.	Iron	147-151	transferrin	Homo sapiens	29-31
1651123-5	1991	Observation of iron-13C coupling in the electron spin echo envelope modulation (ESEEM) for iron transferrin [1-13C]pyruvate indicated that the carboxylate group was bound to the iron.	Iron	91-95	transferrin	Homo sapiens	96-107
2029033-0	1991	Iron repletion as a contribution to erythropoietin treatment of anemia in rheumatoid arthritis.	Iron	0-4	erythropoietin	Homo sapiens	36-50
1883959-4	1991	The IV injection of IL-6 decreased the plasma concentration of iron and zinc and increased the circulating leukocyte count.	Iron	63-67	interleukin-6	Oryctolagus cuniculus	20-24
1651123-0	1991	Effect of the synergistic anion on electron paramagnetic resonance spectra of iron-transferrin anion complexes is consistent with bidentate binding of the anion.	Iron	78-82	transferrin	Homo sapiens	83-94
1651123-1	1991	Continuous wave (cw) X-band EPR spectra at approximately 90 K were obtained for iron-transferrin-anion complexes with 18 anions.	Iron	80-84	transferrin	Homo sapiens	85-96
1651123-5	1991	Observation of iron-13C coupling in the electron spin echo envelope modulation (ESEEM) for iron transferrin [1-13C]pyruvate indicated that the carboxylate group was bound to the iron.	Iron	15-19	transferrin	Homo sapiens	96-107
1651123-5	1991	Observation of iron-13C coupling in the electron spin echo envelope modulation (ESEEM) for iron transferrin [1-13C]pyruvate indicated that the carboxylate group was bound to the iron.	Iron	91-95	transferrin	Homo sapiens	96-107
2019882-3	1991	Hemoglobin, liver iron and transferrin saturation were significantly lower in the 4 and 6 mg Fe/kg diet groups relative to the other groups and were indicative of anemia, low tissue iron stores and impaired erythropoiesis.	Iron	93-95	transferrin	Rattus norvegicus	27-38
1826464-0	1991	Role of iron in T cell activation: TH1 clones differ from TH2 clones in their sensitivity to inhibition of DNA synthesis caused by IgG Mabs against the transferrin receptor and the iron chelator deferoxamine.	Iron	8-12	transferrin	Homo sapiens	152-163
2026245-2	1991	The monoclonal antibodies able to bind SOD were further screened for their ability to absorb SOD activity using anti-mouse IgG conjugated iron beads as solid supports in magnetic separation.	Iron	138-142	superoxide dismutase 1	Homo sapiens	93-96
2015630-6	1991	In addition to hemin, as we have previously reported, and FAC, a variety of iron-containing proteins have lymphocyte stimulatory properties in combination with IL-2.	Iron	76-80	interleukin 2	Homo sapiens	160-164
2013104-5	1991	Iron-saturated human transferrin, lactotransferrin, and egg transferrin (conalbumin) were assayed in irradiated C57BL/6 mice infused with bone marrow from histoincompatible BALB/c donors.	Iron	0-4	transferrin	Homo sapiens	21-32
2016326-9	1991	This study demonstrates that the complex role of TNF and IL-1 in iron homeostasis includes modulation of the transferrin receptor.	Iron	65-69	tumor necrosis factor	Homo sapiens	49-52
2018478-1	1991	Rhodanese (EC 2.8.1.1), a mitochondrial thiosulphate sulphurtransferase, is involved in the formation of iron-sulphur complexes and cyanide detoxification.	Iron	105-109	thiosulfate sulfurtransferase	Rattus norvegicus	0-9
2018119-3	1991	Because Al as well as iron (Fe) can bind to transferrin (TF) in plasma, the role of TF as a modifier of osteoblast proliferation was examined in UMR-106-01 osteoblast-like cells by measuring the incorporation of tritiated thymidine ([3H]-TdR) into DNA (counts.min-1.microgram cell protein-1, means +/- SE) during 48-h incubations in serum-free medium (SFM).	Iron	28-30	transferrin	Rattus norvegicus	44-55
1906763-0	1991	Iron-mediated induction of the SOS responses by hydrogen peroxide.	Iron	0-4	xylosyltransferase 2	Homo sapiens	31-34
2015874-3	1991	In ACD the serum Epo (mean (confidence limits] results of 41 (31, 54) mU/ml for the rheumatoid group and 63 (49, 80) mU/ml for the malignancy group, were significantly lower than the Epo of 104 (78, 136) mU/ml for the iron-deficiency group.	Iron	218-222	erythropoietin	Homo sapiens	17-20
1873357-7	1991	IL-1 beta treatment also resulted in decreases in serum iron levels and in the albumin/globulin ratio, well-established in vivo effects of IL-1.	Iron	56-60	interleukin 1 beta	Homo sapiens	0-9
2050655-5	1991	The NDH-2 enzymes are generally single polypeptides and contain noncovalently bound FAD and no iron-sulfur clusters.	Iron	95-99	DExH-box helicase 9	Homo sapiens	4-9
2001452-0	1991	Induction of protein kinase C mRNA in cultured lymphoblastoid T cells by iron-transferrin but not by soluble iron.	Iron	73-77	transferrin	Homo sapiens	78-89
2042019-1	1991	Serum ferritin (S-ferritin) and the saturation of transferrin iron-binding capacity (TIBC-sat) were evaluated as screening procedures for idiopathic haemochromatosis in a non-diseased population.	Iron	62-66	transferrin	Homo sapiens	50-61
1849482-1	1991	The spectral changes caused by binding soft ligands to the cytochrome c iron and their correlation to ligand affinities support the hypothesis that the iron-methionine sulfur bond of this heme protein is enhanced by delocalization of the metal t2g electrons into the empty 3d orbitals of the ligand atom.	Iron	72-76	cytochrome c, somatic	Homo sapiens	59-71
1849482-1	1991	The spectral changes caused by binding soft ligands to the cytochrome c iron and their correlation to ligand affinities support the hypothesis that the iron-methionine sulfur bond of this heme protein is enhanced by delocalization of the metal t2g electrons into the empty 3d orbitals of the ligand atom.	Iron	152-156	cytochrome c, somatic	Homo sapiens	59-71
1648368-4	1991	Essentially the same effects were observed in SOD containing either Mn or Fe in the catalytic center.	Iron	74-76	superoxide dismutase 1	Homo sapiens	46-49
1865507-15	1991	Investigation of influencing factors on response to EPO suggests that 1) TIW group had a better response than BIW group 2) Response was better in patients with more adequate iron status and less severe Al burden.	Iron	174-178	erythropoietin	Homo sapiens	52-55
1865507-18	1991	Dosing regimen, iron status, and serum Al will influence the response to EPO.	Iron	16-20	erythropoietin	Homo sapiens	73-76
1993673-0	1991	Regulation of the transferrin-independent iron transport system in cultured cells.	Iron	42-46	transferrin	Homo sapiens	18-29
2022700-3	1991	We have investigated the role of the transferrin cycle in this mutant by bypassing transferrin iron delivery with the iron chelate ferric salicylaldehyde isonicotinoyl hydrazone (Fe-SIH).	Iron	95-99	transferrin	Rattus norvegicus	83-94
2022700-12	1991	The Belgrade defect occurs in the movement of iron from transferrin to a step prior to the ferrous state and insertion into heme.	Iron	46-50	transferrin	Rattus norvegicus	56-67
1996102-2	1991	For example, transferrin synthesized by the Sertoli cell is important in delivering iron from the serum to the developing germ cells.	Iron	84-88	transferrin	Rattus norvegicus	13-24
1847381-1	1991	Salicylhydroxamic and benzohydroxamic acids were found to bind to the resting state of myeloperoxidase and inhibit ligand binding to the heme iron.	Iron	142-146	myeloperoxidase	Homo sapiens	87-102
1846735-13	1991	Cytochrome P450 may function to generate the H2O2 and reduce the nonheme iron.	Iron	73-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
1896380-7	1991	In a second step progressing iron deficiency will be assessed by lowered serum iron and increased unsaturated serum transferrin, serum iron bound to transferrin and erythrocyte protoporphyrin IX.	Iron	29-33	transferrin	Homo sapiens	116-127
1896380-7	1991	In a second step progressing iron deficiency will be assessed by lowered serum iron and increased unsaturated serum transferrin, serum iron bound to transferrin and erythrocyte protoporphyrin IX.	Iron	29-33	transferrin	Homo sapiens	149-160
2001412-1	1991	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	transferrin	Homo sapiens	16-27
2001412-5	1991	Iron release was linear with time, while transferrin release was biphasic, suggesting that iron was leaving the cell independently of transferrin.	Iron	91-95	transferrin	Homo sapiens	41-52
2001412-11	1991	The non-transferrin-bound membrane Fe did not decrease during reincubation periods up to 5 h, suggesting that the cell was not utilising it.	Iron	35-37	transferrin	Homo sapiens	8-19
1993673-1	1991	Mammalian cells accumulate iron via the binding of transferrin to high affinity surface receptors, or through a transferrin-independent pathway which involves the uptake of iron-organic anion chelates by a membrane-based transport system.	Iron	27-31	transferrin	Homo sapiens	51-62
1993673-1	1991	Mammalian cells accumulate iron via the binding of transferrin to high affinity surface receptors, or through a transferrin-independent pathway which involves the uptake of iron-organic anion chelates by a membrane-based transport system.	Iron	173-177	transferrin	Homo sapiens	112-123
1993673-6	1991	In this communication we demonstrate that the transferrin-independent iron uptake system is regulated differently than the transferrin-mediated pathway.	Iron	70-74	transferrin	Homo sapiens	46-57
1993673-10	1991	The ability of other transition metals to induce changes in transport, or to compete with iron for accumulation by the transferrin-independent uptake system, was critically dependent on the composition of the media in which the cells were incubated.	Iron	90-94	transferrin	Homo sapiens	119-130
1993673-13	1991	The Vmax of the transferrin-independent iron transport system was also elevated by increases in intracellular Ca2+.	Iron	40-44	transferrin	Homo sapiens	16-27
1992468-7	1991	One possibility is that ferroxidase activity may interfere with the cellular uptake of transferrin iron that is needed for cell proliferation, an interpretation consistent with the presently described ability of hemin to overcome H-ferritin suppressive effects.	Iron	99-103	transferrin	Homo sapiens	87-98
2004025-7	1991	These data suggest that the most likely role of the transferrin receptor in the neonatal intestine is in the supply of iron to the developing epithelial cells in the crypts, and that the receptor does not play a direct role in iron transit across the intestinal epithelium.	Iron	119-123	transferrin	Rattus norvegicus	52-63
1826735-2	1991	Acquisition of iron for growth from Fe-transferrin in serum was dependent on the siderophore amonabactin; 50 of 54 amonabactin-producing isolates grew in heat-inactivated serum, whereas none of 30 enterobactin-producing strains were able to grow.	Iron	15-19	transferrin	Homo sapiens	39-50
2051996-1	1991	Placental transferrin receptors, located at the apical side of syncytiotrophoblast, mediate placental iron uptake.	Iron	102-106	transferrin	Homo sapiens	10-21
1671034-2	1991	Both EGF and its receptor are thought to be targeted for destruction in lysosomes, leading to down-regulation of the receptor, whereas transferrin, after unloading iron within the cell, is thought to recycle to the cell surface bound to its receptor.	Iron	164-168	transferrin	Rattus norvegicus	135-146
1988034-5	1991	Iron removal of 0.05 M pyrophosphate at pH 7.4 from diferric transferrin bound to the receptor is considerably slower than that from free diferric transferrin, with observed pseudo-first-order rate constants of 0.020 and 0.191 min-1, respectively.	Iron	0-4	transferrin	Homo sapiens	61-72
1988034-7	1991	However, at pH 5.6, iron removal by 0.001 M pyrophosphate is faster from diferric transferrin bound to its receptor than from free transferrin (observed rate constants of 0.819 and 0.160 min-1, respectively).	Iron	20-24	transferrin	Homo sapiens	82-93
1988034-7	1991	However, at pH 5.6, iron removal by 0.001 M pyrophosphate is faster from diferric transferrin bound to its receptor than from free transferrin (observed rate constants of 0.819 and 0.160 min-1, respectively).	Iron	20-24	transferrin	Homo sapiens	131-142
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	67-71	transferrin	Homo sapiens	10-21
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	67-71	transferrin	Homo sapiens	86-97
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	67-71	transferrin	Homo sapiens	86-97
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	189-193	transferrin	Homo sapiens	10-21
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	189-193	transferrin	Homo sapiens	86-97
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	189-193	transferrin	Homo sapiens	86-97
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	189-193	transferrin	Homo sapiens	10-21
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	189-193	transferrin	Homo sapiens	86-97
1988034-8	1991	Thus, the transferrin receptor not only facilitates the removal of iron from diferric transferrin at the low pH that prevails in endocytic vesicles but may also reduce its accessibility to iron acceptors at extracellular pH, thereby minimizing the likelihood of nonspecific release of iron from transferrin at the cell surface.	Iron	189-193	transferrin	Homo sapiens	86-97
1985771-1	1991	The process of cellular iron uptake involves a specific receptor for the plasma carrier transferrin and a pathway of receptor-mediated endocytosis.	Iron	24-28	transferrin	Homo sapiens	88-99
1988034-0	1991	A new role for the transferrin receptor in the release of iron from transferrin.	Iron	58-62	transferrin	Homo sapiens	19-30
1988034-0	1991	A new role for the transferrin receptor in the release of iron from transferrin.	Iron	58-62	transferrin	Homo sapiens	68-79
1988034-1	1991	Iron removal by pyrophosphate from human serum diferric transferrin and the complex of transferrin with its receptor was studied in 0.05 M HEPES or MES buffers containing 0.1 M NaCl and 0.01 M CHAPS at 25 degrees C at pH 7.4, 6.4, and 5.6.	Iron	0-4	transferrin	Homo sapiens	56-67
2051996-7	1991	Treatment with iron-sources results in a down regulation of transferrin receptors.	Iron	15-19	transferrin	Homo sapiens	60-71
2051996-8	1991	Thus, though the level of transferrin receptors in cultured normal trophoblast is at a constant level, unaffected by differentiation, high levels of maternal transferrin-iron availability can lead to a decrease in placental iron uptake.	Iron	170-174	transferrin	Homo sapiens	158-169
2051996-8	1991	Thus, though the level of transferrin receptors in cultured normal trophoblast is at a constant level, unaffected by differentiation, high levels of maternal transferrin-iron availability can lead to a decrease in placental iron uptake.	Iron	224-228	transferrin	Homo sapiens	158-169
2051996-2	1991	Regulation of transferrin receptors on the fetal-maternal exchange area could be a major determinant in the regulation of trans-placental iron transport.	Iron	138-142	transferrin	Homo sapiens	14-25
2037233-5	1991	Such mutants should prove useful in further elucidating the mechanism of transferrin iron-acquisition and its contribution to the virulence of H. influenzae.	Iron	85-89	transferrin	Homo sapiens	73-84
1845997-0	1991	Initial iron oxidation in horse spleen apoferritin.	Iron	8-12	ferritin heavy chain	Equus caballus	39-50
1845997-3	1991	Two intermediates, formed during the initial stages of iron accumulation in apoferritin, have been observed previously in our laboratory and have been identified as a mononuclear Fe3(+)-protein complex and a mixed-valence Fe2(+)-Fe3(+)-protein complex.	Iron	55-59	ferritin heavy chain	Equus caballus	76-87
1846080-4	1991	A good fit of the absorption spectra of six different cytochrome P-450 proteins in the presence and absence of substrates was found, indicating a similar pi-electron structure of the porphyrin and a similar chemical nature of the nearest coordination sphere of the iron in all cytochrome P-450 proteins.	Iron	265-269	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	54-70
2037235-0	1991	Acquisition of iron from transferrin by Bordetella pertussis.	Iron	15-19	transferrin	Homo sapiens	25-36
1846080-4	1991	A good fit of the absorption spectra of six different cytochrome P-450 proteins in the presence and absence of substrates was found, indicating a similar pi-electron structure of the porphyrin and a similar chemical nature of the nearest coordination sphere of the iron in all cytochrome P-450 proteins.	Iron	265-269	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	277-293
2037235-1	1991	It has been demonstrated that under iron-restricted conditions Bordetella pertussis can take up iron from human transferrin within 30 min of exposure.	Iron	36-40	transferrin	Homo sapiens	112-123
2037235-1	1991	It has been demonstrated that under iron-restricted conditions Bordetella pertussis can take up iron from human transferrin within 30 min of exposure.	Iron	96-100	transferrin	Homo sapiens	112-123
2037235-2	1991	B. pertussis utilizes two mechanisms for acquiring iron from human transferrin, a direct contact method and a siderophore mediated system.	Iron	51-55	transferrin	Homo sapiens	67-78
2037235-3	1991	Both systems are shown to result in bacterial internalization of iron from transferrin.	Iron	65-69	transferrin	Homo sapiens	75-86
2037235-4	1991	However, direct contact between B. pertussis and transferrin provides far more effective iron uptake than siderophore activity alone.	Iron	89-93	transferrin	Homo sapiens	49-60
1805491-2	1991	A 55-year-old female patient with hemosiderosis induced by administration of excessive doses of parenteral iron was successfully treated with regular phlebotomy combined with recombinant human erythropoietin (rHuEPO).	Iron	107-111	erythropoietin	Homo sapiens	193-207
2050759-8	1991	Conversely, the iron-saturated and iron-free forms of transferrin were only separated by imidazole affinity elution.	Iron	16-20	transferrin	Homo sapiens	54-65
2050759-8	1991	Conversely, the iron-saturated and iron-free forms of transferrin were only separated by imidazole affinity elution.	Iron	35-39	transferrin	Homo sapiens	54-65
1931436-8	1991	These values imply that, in the physiological range of Tf concentrations, about 75% of the Fe taken up by hepatocytes may be due to a pinocytic mechanism (fluid-phase or mixed).	Iron	91-93	transferrin	Rattus norvegicus	55-57
2050759-12	1991	In summary, independent of species, the affinity for immobilized Cu(II) ions increased as follows: iron-saturated ovotransferrin less than metal-free ovotransferrin less than apolactoferrin less than hololactoferrin much less than diferric or holotransferrin less than monoferric transferrin less than apotransferrin.	Iron	99-103	transferrin	Homo sapiens	117-128
1846518-0	1991	Ferrous iron release from transferrin by human neutrophil-derived superoxide anion: effect of pH and iron saturation.	Iron	0-12	transferrin	Homo sapiens	26-37
1846518-0	1991	Ferrous iron release from transferrin by human neutrophil-derived superoxide anion: effect of pH and iron saturation.	Iron	8-12	transferrin	Homo sapiens	26-37
1846518-1	1991	The ability of superoxide anion (O2-) from stimulated human neutrophils (PMNs) to release ferrous iron (Fe2+) from transferrin was assessed.	Iron	90-102	transferrin	Homo sapiens	115-126
1846518-5	1991	In contrast, at physiologic pH (7.4), incubation of transferrin at physiological levels of iron saturation (e.g. 32%) with unstimulated or PMA stimulated PMNs failed to facilitate the release of Fe2+.	Iron	91-95	transferrin	Homo sapiens	52-63
1846518-7	1991	Decreasing the pH greatly facilitated the release of Fe2+ from both holosaturated transferrin and from transferrin at physiological levels of iron saturation by PMN-derived O2-.	Iron	142-146	transferrin	Homo sapiens	103-114
1846518-9	1991	These results suggest that transferrin at physiologic levels of iron saturation may serve as a source of Fe2+ for biological reactions in disease states where activated phagocytes are present and there is a decrease in tissue pH.	Iron	64-68	transferrin	Homo sapiens	27-38
1883640-1	1991	Hepatocytes take up transferrin-bound iron by two mechanisms.	Iron	38-42	transferrin	Homo sapiens	20-31
1883640-4	1991	The other mechanism involves low affinity, non-specific and non-saturable internalization of transferrin-bound iron, probably through pinocytosis, adsorptive endocytosis or low affinity binding sites.	Iron	111-115	transferrin	Homo sapiens	93-104
1883640-6	1991	A mechanism whereby transferrin-bound iron is not endocytosed but reduced at and translocated through the plasma membrane has also been invoked and challenges the concept of (receptor-mediated) endocytosis of transferrin.	Iron	38-42	transferrin	Homo sapiens	20-31
1883640-6	1991	A mechanism whereby transferrin-bound iron is not endocytosed but reduced at and translocated through the plasma membrane has also been invoked and challenges the concept of (receptor-mediated) endocytosis of transferrin.	Iron	38-42	transferrin	Homo sapiens	209-220
1854588-6	1991	The same RNA-protein motif is used, through iron-dependent degradation of transferrin receptor mRNA, to decrease synthesis of the receptor and cellular iron uptake.	Iron	44-48	transferrin	Homo sapiens	74-85
1854588-6	1991	The same RNA-protein motif is used, through iron-dependent degradation of transferrin receptor mRNA, to decrease synthesis of the receptor and cellular iron uptake.	Iron	152-156	transferrin	Homo sapiens	74-85
1847276-3	1991	Iron can be taken up by the liver in several forms and by several pathways including: (1) receptor-mediated endocytosis of diferric or monoferric transferrin or ferritin, (2) reduction and carrier-facilitated internalization of iron from transferrin without internalization of the protein moiety of transferrin, (3) electrogenic uptake of low molecular weight, non-protein bound forms of iron, and (4) uptake of heme from heme-albumin, heme-hemopexin, or hemoglobin-haptoglobin complexes.	Iron	0-4	transferrin	Homo sapiens	146-157
1847276-3	1991	Iron can be taken up by the liver in several forms and by several pathways including: (1) receptor-mediated endocytosis of diferric or monoferric transferrin or ferritin, (2) reduction and carrier-facilitated internalization of iron from transferrin without internalization of the protein moiety of transferrin, (3) electrogenic uptake of low molecular weight, non-protein bound forms of iron, and (4) uptake of heme from heme-albumin, heme-hemopexin, or hemoglobin-haptoglobin complexes.	Iron	0-4	transferrin	Homo sapiens	238-249
1847276-3	1991	Iron can be taken up by the liver in several forms and by several pathways including: (1) receptor-mediated endocytosis of diferric or monoferric transferrin or ferritin, (2) reduction and carrier-facilitated internalization of iron from transferrin without internalization of the protein moiety of transferrin, (3) electrogenic uptake of low molecular weight, non-protein bound forms of iron, and (4) uptake of heme from heme-albumin, heme-hemopexin, or hemoglobin-haptoglobin complexes.	Iron	0-4	transferrin	Homo sapiens	238-249
1847276-6	1991	Iron in hepatocytes stimulates translation of ferritin mRNA and represses transcription of DNA for transferrin and transferrin receptors.	Iron	0-4	transferrin	Homo sapiens	99-110
1847276-6	1991	Iron in hepatocytes stimulates translation of ferritin mRNA and represses transcription of DNA for transferrin and transferrin receptors.	Iron	0-4	transferrin	Homo sapiens	115-126
1854587-0	1991	Characteristics of the interaction of the ferritin repressor protein with the iron-responsive element.	Iron	78-82	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	42-68
1854587-1	1991	The iron-responsive regulation of ferritin mRNA translation is mediated by the specific interaction of the ferritin repressor protein (FRP) with the iron-responsive element (IRE), a highly conserved 28-nucleotide sequence located in the 5" untranslated region of ferritin mRNAs.	Iron	4-8	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	107-133
1854587-1	1991	The iron-responsive regulation of ferritin mRNA translation is mediated by the specific interaction of the ferritin repressor protein (FRP) with the iron-responsive element (IRE), a highly conserved 28-nucleotide sequence located in the 5" untranslated region of ferritin mRNAs.	Iron	4-8	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	135-138
1854587-1	1991	The iron-responsive regulation of ferritin mRNA translation is mediated by the specific interaction of the ferritin repressor protein (FRP) with the iron-responsive element (IRE), a highly conserved 28-nucleotide sequence located in the 5" untranslated region of ferritin mRNAs.	Iron	149-153	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	107-133
1854587-1	1991	The iron-responsive regulation of ferritin mRNA translation is mediated by the specific interaction of the ferritin repressor protein (FRP) with the iron-responsive element (IRE), a highly conserved 28-nucleotide sequence located in the 5" untranslated region of ferritin mRNAs.	Iron	149-153	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	135-138
1854587-3	1991	The activity of FRP is sensitive to iron in vivo.	Iron	36-40	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	16-19
1854587-4	1991	Cytoplasmic extracts of rabbit kidney cells show reduction of FRP activity when grown in the presence of iron, as detected by RNA band shift assay.	Iron	105-109	cytoplasmic aconitate hydratase	Oryctolagus cuniculus	62-65
1760751-0	1991	Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic haemochromatosis patients.	Iron	81-85	CD4 molecule	Homo sapiens	60-63
1760751-5	1991	Follow-up of iron reentry into the transferrin pool at the end of the intensive phlebotomy treatment indicates that the relative proportion of circulating CD4/CD8 cells is critically related to the regulation of iron absorption.	Iron	13-17	transferrin	Homo sapiens	35-46
1760751-5	1991	Follow-up of iron reentry into the transferrin pool at the end of the intensive phlebotomy treatment indicates that the relative proportion of circulating CD4/CD8 cells is critically related to the regulation of iron absorption.	Iron	13-17	CD4 molecule	Homo sapiens	155-158
1760751-5	1991	Follow-up of iron reentry into the transferrin pool at the end of the intensive phlebotomy treatment indicates that the relative proportion of circulating CD4/CD8 cells is critically related to the regulation of iron absorption.	Iron	212-216	CD4 molecule	Homo sapiens	155-158
1675959-0	1991	Specificity of hepatic iron uptake from plasma transferrin in the rat.	Iron	23-27	transferrin	Rattus norvegicus	47-58
2054965-11	1991	Epo response might correlate inversely with iron stores.	Iron	44-48	erythropoietin	Homo sapiens	0-3
1675959-2	1991	The role of specific interaction between transferrin and its receptors in iron uptake by the liver in vivo was investigated using 59Fe-125I-labelled transferrins from several animal species, and adult and 15-day rats.	Iron	74-78	transferrin	Rattus norvegicus	41-52
1675959-11	1991	It is concluded that iron uptake by the liver from plasma transferrin in vivo is largely or completely dependent on specific transferrin-receptor interaction.	Iron	21-25	transferrin	Rattus norvegicus	58-69
1675959-11	1991	It is concluded that iron uptake by the liver from plasma transferrin in vivo is largely or completely dependent on specific transferrin-receptor interaction.	Iron	21-25	transferrin	Rattus norvegicus	125-136
1991464-0	1991	Fe3+(2)-transferrin and Fe3+(2)-asialotransferrin deliver iron to hepatocytes by an identical mechanism.	Iron	58-62	transferrin	Rattus norvegicus	8-19
1874246-7	1991	The transferrin-iron saturation had decreased below pre-altitude values (mean 23%, SD 4%) on day 4 postaltitude (mean 14%, SD 5%) and had increased on day 11 postaltitude (mean 22%, SD 7%).	Iron	16-20	transferrin	Homo sapiens	4-15
1991464-8	1991	Despite the different properties of the two ligands, the rates of iron uptake from 59Fe3+(2)-transferrin and 59Fe3+(2)-asialotransferrin were identical, suggesting a common mechanism for the translocation of iron across the plasma (or possibly endosomal) membrane such as a transmembrane oxidoreductase.	Iron	66-70	transferrin	Rattus norvegicus	93-104
1991464-11	1991	The release of iron at the hepatocyte cell surface would effectively uncouple the two functions and render the hepatocyte unresponsive to growth stimulation by transferrin.	Iron	15-19	transferrin	Rattus norvegicus	160-171
1937137-4	1991	Using a model system of ferrous iron and ferric cytochrome c, it was determined that substitution of GTP for GDP led to an enhanced reduction of ferric cytochrome c.	Iron	32-36	cytochrome c, somatic	Homo sapiens	152-164
12106249-1	1991	Iron-saturated transferrin is a ubiquitous growth factor that plays a critical role in cellular iron uptake, growth and proliferation.	Iron	0-4	transferrin	Rattus norvegicus	15-26
12106249-1	1991	Iron-saturated transferrin is a ubiquitous growth factor that plays a critical role in cellular iron uptake, growth and proliferation.	Iron	96-100	transferrin	Rattus norvegicus	15-26
12106249-6	1991	In addition, studies using intravenously injected radioactive iron (59Fe3+) showed a massive increase in endoneural iron uptake confined to the lesion site and to the distal part of the axotomised sciatic nerve, parallel to the time course of reactive transferrin receptor expression.	Iron	62-66	transferrin	Rattus norvegicus	252-263
12106249-6	1991	In addition, studies using intravenously injected radioactive iron (59Fe3+) showed a massive increase in endoneural iron uptake confined to the lesion site and to the distal part of the axotomised sciatic nerve, parallel to the time course of reactive transferrin receptor expression.	Iron	116-120	transferrin	Rattus norvegicus	252-263
12106249-7	1991	Since iron is an essential cofactor of a number of key enzymes needed in energy metabolism and DNA synthesis, these data suggest that the induction of transferrin receptor expression may play an important role in the regulation of cellular growth and proliferation during peripheral nerve regeneration.	Iron	6-10	transferrin	Rattus norvegicus	151-162
1649085-4	1991	Furthermore, neutrophil lactoferrin and myeloperoxidase limit the magnitude (and in the case of lactoferrin the duration) of hydroxyl radical formed by neutrophils in an iron catalyzed system.	Iron	170-174	lactotransferrin	Homo sapiens	13-35
1649085-4	1991	Furthermore, neutrophil lactoferrin and myeloperoxidase limit the magnitude (and in the case of lactoferrin the duration) of hydroxyl radical formed by neutrophils in an iron catalyzed system.	Iron	170-174	myeloperoxidase	Homo sapiens	40-55
1802733-3	1991	In the absence of any other protein human iron-free transferrin was able to strongly enhance endotoxicity in a concentration-dependent manner.	Iron	42-46	transferrin	Homo sapiens	52-63
1744249-0	1991	Role of transferrin in iron uptake by the brain: a comparative study.	Iron	23-27	transferrin	Rattus norvegicus	8-19
2055611-5	1991	After one month, the anemic patients receiving oral iron therapy showed a significant increase in hemoglobin concentration, per cent transferrin saturation and platelet MAO activity (p less than 0.05).	Iron	52-56	transferrin	Homo sapiens	133-144
2055611-7	1991	Although hemoglobin and transferrin saturation did not return to normal levels, these findings suggested that platelet MAO activity increased and urinary excretion of metanephrines decreased after iron medication.	Iron	197-201	transferrin	Homo sapiens	24-35
1800620-4	1991	Also, preincubation of ferrous sulphate with thrombin or with pure fibrinogen indicated that iron could produce decrease of thrombin activity as well as impairment of fibrinogen clottability.	Iron	93-97	coagulation factor II	Rattus norvegicus	124-132
1744249-1	1991	The role of specific transferrin (Tf) and Tf receptor interaction on brain capillary endothelial cells in iron transport from the plasma to the brain was investigated by using Tf from several species of animals labeled with 59Fe and 125I, and 15-day and adult rats.	Iron	106-110	transferrin	Rattus norvegicus	42-44
1744249-1	1991	The role of specific transferrin (Tf) and Tf receptor interaction on brain capillary endothelial cells in iron transport from the plasma to the brain was investigated by using Tf from several species of animals labeled with 59Fe and 125I, and 15-day and adult rats.	Iron	106-110	transferrin	Rattus norvegicus	42-44
1744249-6	1991	It is concluded that iron transport into the brain is dependent on the function of Tf receptors, probably on capillary endothelial cells, and that these receptors show the same type of species specificity as the receptors on immature erythroid cells.	Iron	21-25	transferrin	Rattus norvegicus	83-85
1800620-4	1991	Also, preincubation of ferrous sulphate with thrombin or with pure fibrinogen indicated that iron could produce decrease of thrombin activity as well as impairment of fibrinogen clottability.	Iron	93-97	coagulation factor II	Rattus norvegicus	45-53
1995763-7	1991	We conclude that differences in S-EPO concentration in ACD may be further related to the patient"s iron stores and temperature.	Iron	99-103	erythropoietin	Homo sapiens	34-37
1717745-1	1991	Though the total iron-binding activity of the blood serum directly depends on blood serum transferrin level, these are different parameters.	Iron	17-21	transferrin	Homo sapiens	90-101
2043719-0	1991	Speciation of non-transferrin-bound iron ions in synovial fluid from patients with rheumatoid arthritis by proton nuclear magnetic resonance spectroscopy.	Iron	36-40	transferrin	Homo sapiens	18-29
1717745-2	1991	It is possible to measure transferrin levels with direct estimation of the share of this protein saturation with iron without preliminary measurement of the total iron-binding activity of the blood serum.	Iron	113-117	transferrin	Homo sapiens	26-37
1766258-1	1991	We have examined the expression of the protein tyrosine kinase (PTK) encoding oncogenes fes and abl in normal and malignant human myeloid cells in immunoblotting experiments.	Iron	88-91	EPH receptor A8	Homo sapiens	39-62
1766258-1	1991	We have examined the expression of the protein tyrosine kinase (PTK) encoding oncogenes fes and abl in normal and malignant human myeloid cells in immunoblotting experiments.	Iron	88-91	EPH receptor A8	Homo sapiens	64-67
2025345-1	1991	Transferrin ist the transport protein of iron known to be an essential element of life.	Iron	41-45	transferrin	Homo sapiens	0-11
1717745-3	1991	The degree of transferrin saturation with iron is virtually unrelated to the results of its measurement by various immunochemical methods.	Iron	42-46	transferrin	Homo sapiens	14-25
1797162-1	1991	Transferrin receptors take up transferrin-iron complexes into hepatic cells.	Iron	42-46	transferrin	Homo sapiens	0-11
27457579-4	1991	at 4 C and 37 C. Transmission electron microscopy demonstrated that, although the CD10 MoAb-particles complex linked to the cell surface only at 4 C, they readily penetrated into cells at 37 C. In contrast, after incubation with CD8 MoAb-particles, no iron particles were seen at the cell surface, or within the cells no matter what the temperature and duration of the incubation were.	Iron	252-256	membrane metalloendopeptidase	Homo sapiens	82-86
1820488-9	1991	Iron-carrying transferrin is in fact a growth factor.	Iron	0-4	transferrin	Homo sapiens	14-25
2029463-9	1991	Injection with iron on day 13 led to a rapid increase in the above mentioned parameters, with statistically significant increases for Hb, PCV, and MCV four days after treatment.	Iron	15-19	MCV	Sus scrofa	147-150
2029463-12	1991	Furthermore, the present study also indicates that MCV is a sensitive indicator of iron availability in piglets.	Iron	83-87	MCV	Sus scrofa	51-54
2043266-4	1991	Moreover, the transferrin receptors in cancer cells were less affected by iron overloading as compared with epithelial cells.	Iron	74-78	transferrin	Homo sapiens	14-25
1646497-1	1991	An immunoperoxidase staining technique was used for detecting three major iron-binding proteins (transferrin, ferritin and lactoferrin) in 54 adenoid cystic carcinomas (ACCs) of major and minor salivary glands.	Iron	74-78	transferrin	Homo sapiens	97-108
1645976-0	1991	Targeting iron-dependent DNA synthesis with gallium and transferrin-gallium.	Iron	10-14	transferrin	Homo sapiens	56-67
1645976-2	1991	Gallium, a metal which resembles iron with respect to transferrin (Tf) binding, cellular uptake by the Tf receptor and incorporation into ferritin, blocks the cellular uptake of iron and inhibits cell growth.	Iron	33-37	transferrin	Homo sapiens	54-65
1797162-1	1991	Transferrin receptors take up transferrin-iron complexes into hepatic cells.	Iron	42-46	transferrin	Homo sapiens	30-41
2239935-0	1990	Bioavailability of iron in hemodialysis patients treated with erythropoietin: evidence for the inhibitory role of aluminum.	Iron	19-23	erythropoietin	Homo sapiens	62-76
2151461-0	1990	Response of Haemophilus somnus to iron limitation: expression and identification of a bovine-specific transferrin receptor.	Iron	34-38	transferrin	Homo sapiens	102-113
2151461-4	1990	When iron-deficient cells from these strains were screened for their ability to bind peroxidase-conjugated transferrin, binding was detected with conjugated bovine, but not human or porcine transferrin.	Iron	5-9	serotransferrin	Bos taurus	107-118
1702420-7	1990	The above data combined with iron uptake by promastigotes as demonstrated by the Prussian blue reaction indicate that the 78-kDa Leishmania membrane-associated glycoprotein is transferrin.	Iron	29-33	transferrin	Homo sapiens	176-187
2268267-1	1990	Incubation of human erythroleukaemia K562 cells with Al-transferrin inhibited iron uptake from 59Fe-transferrin by about 80%.	Iron	78-82	transferrin	Homo sapiens	56-67
2268267-1	1990	Incubation of human erythroleukaemia K562 cells with Al-transferrin inhibited iron uptake from 59Fe-transferrin by about 80%.	Iron	78-82	transferrin	Homo sapiens	100-111
2268267-9	1990	It is proposed that aluminium, when bound to transferrin, inhibits iron uptake partly by down-regulating transferrin-receptor expression and partly by interfering with intracellular release of iron from transferrin.	Iron	67-71	transferrin	Homo sapiens	45-56
2268267-9	1990	It is proposed that aluminium, when bound to transferrin, inhibits iron uptake partly by down-regulating transferrin-receptor expression and partly by interfering with intracellular release of iron from transferrin.	Iron	67-71	transferrin	Homo sapiens	105-116
2268267-9	1990	It is proposed that aluminium, when bound to transferrin, inhibits iron uptake partly by down-regulating transferrin-receptor expression and partly by interfering with intracellular release of iron from transferrin.	Iron	193-197	transferrin	Homo sapiens	45-56
2122975-6	1990	Addition, during anoxia, of a 200 micrograms/ml concentration of the superoxide anion radical scavenger superoxide dismutase or of a 5 mM concentration of the iron chelator deferoxamine mesylate prevented the subsequent decrease of t-PA antigen during reoxygenation; addition of these compounds during reoxygenation had no effect.	Iron	159-163	plasminogen activator, tissue type	Homo sapiens	232-236
2246244-3	1990	X-ray crystallography has shown that the heme cavity can easily accommodate ligands the size of nicotinate, and analysis of extended x-ray absorption fine structure data has shown that the Fe atom is in the mean plane of the heme in the leghemoglobin-CO complex.	Iron	189-191	leghemoglobin A	Glycine max	237-250
2239943-2	1990	Aluminum can blunt the effect of erythropoietin, in part by interfering with iron bioavailability.	Iron	77-81	erythropoietin	Homo sapiens	33-47
2209759-9	1990	Conversely, binding of iron to transferrin was minimal.	Iron	23-27	transferrin	Rattus norvegicus	31-42
2256752-0	1990	Correlation of iron exchange between the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one(L1) and transferrin and possible antianaemic effects of L1 in rheumatoid arthritis.	Iron	15-19	transferrin	Homo sapiens	102-113
2256752-0	1990	Correlation of iron exchange between the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one(L1) and transferrin and possible antianaemic effects of L1 in rheumatoid arthritis.	Iron	46-50	transferrin	Homo sapiens	102-113
2289051-0	1990	Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated rats.	Iron	88-92	ferrochelatase	Rattus norvegicus	59-73
2289051-1	1990	The activities of coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase in liver homogenates of iron-overloaded and acutely or chronically ethanol-treated rats were assayed by high performance liquid chromatographic methods.	Iron	116-120	ferrochelatase	Rattus norvegicus	77-91
1703937-6	1990	At low concentrations the relaxivities of iron in serum, about 0.91 mmol-1 l s-1 for ferric and 0.95 mmol-1 l s-1 for ferrous ion, approximate well to the relaxivity of iron in transferrin solutions, which was measured to be about 0.92 mmol-1 l s-1.	Iron	42-46	transferrin	Homo sapiens	177-188
1703937-6	1990	At low concentrations the relaxivities of iron in serum, about 0.91 mmol-1 l s-1 for ferric and 0.95 mmol-1 l s-1 for ferrous ion, approximate well to the relaxivity of iron in transferrin solutions, which was measured to be about 0.92 mmol-1 l s-1.	Iron	169-173	transferrin	Homo sapiens	177-188
1703937-8	1990	These findings imply that iron added to serum first satisfies the binding requirements of transferrin, and the binding of iron to the other serum proteins occurs at high concentrations.	Iron	26-30	transferrin	Homo sapiens	90-101
2128336-19	1990	injection of IL-1 significantly decreased the plasma concentration of iron and zinc and increased the plasma fibrinogen concentration and the circulating leucocyte count in both the control and the trained groups.	Iron	70-74	interleukin 1 beta	Homo sapiens	13-17
2243293-8	1990	RDW and CRP are two of several indicators of iron status in the third National Health and Examination Survey (NHANES III).	Iron	45-49	C-reactive protein	Homo sapiens	8-11
15539176-4	1990	This study was conducted to determine what relationship exists between the declining concentration of milk iron and the transferrin receptor concentration during various stages of lactation.	Iron	107-111	transferrin	Homo sapiens	120-131
15539176-0	1990	Relationship of milk iron and the changing concentration of mammary tissue transferrin receptors during the course of lactation.	Iron	21-25	transferrin	Homo sapiens	75-86
15539176-3	1990	Recently, transferrin receptors have been identified on lactating rat mammary plasma membranes, which may regulate iron entry into mammary tissue, potentiating its availability for subsequent transport into milk.	Iron	115-119	transferrin	Rattus norvegicus	10-21
15539176-7	1990	The continued appearance of high levels of transferrin receptors throughout lactation, without a concomitant increase in milk iron concentration, suggests a need for iron for functions other than cellular growth or secretion into milk to meet infant needs.	Iron	166-170	transferrin	Homo sapiens	43-54
1698536-1	1990	Earlier studies have shown that transferrin-gallium inhibits cellular iron incorporation and blocks DNA synthesis by decreasing the activity of the iron-dependent M2 subunit of ribonucleotide reductase.	Iron	70-74	transferrin	Homo sapiens	32-43
1698536-1	1990	Earlier studies have shown that transferrin-gallium inhibits cellular iron incorporation and blocks DNA synthesis by decreasing the activity of the iron-dependent M2 subunit of ribonucleotide reductase.	Iron	148-152	transferrin	Homo sapiens	32-43
2221071-1	1990	The effect of intracellular iron content on transferrin and iron uptake by cultured hepatocytes isolated from fetal rat liver was examined with ferric ammonium citrate and the iron chelator desferrioxamine (DFO).	Iron	28-32	transferrin	Rattus norvegicus	44-55
2230644-1	1990	Acceleration of the autoxidation of Fe2+ by apotransferrin or apolactoferrin at acid pH is indicated by the disappearance of Fe2+, the uptake of oxygen, and the binding of iron to transferrin or lactoferrin.	Iron	172-176	transferrin	Homo sapiens	47-58
2221071-3	1990	In contrast, when iron-treated cells were incubated with DFO for 24 h, the cellular nonheme iron level was not altered, but the number of transferrin binding sites was increased.	Iron	18-22	transferrin	Rattus norvegicus	138-149
2221071-5	1990	These results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.	Iron	132-136	transferrin	Rattus norvegicus	55-66
2221071-5	1990	These results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.	Iron	195-199	transferrin	Rattus norvegicus	55-66
2221071-5	1990	These results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.	Iron	195-199	transferrin	Rattus norvegicus	116-127
2221071-5	1990	These results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.	Iron	195-199	transferrin	Rattus norvegicus	116-127
2221071-5	1990	These results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.	Iron	195-199	transferrin	Rattus norvegicus	55-66
2221071-5	1990	These results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.	Iron	195-199	transferrin	Rattus norvegicus	116-127
2221071-5	1990	These results indicated that, in cultured hepatocytes, transferrin receptor expression and the subsequent uptake of transferrin and iron are regulated by the size of an intracellular, chelatable iron pool, whereas the uptake of iron by the nonsaturable processes is dependent on the extracellular transferrin concentration.	Iron	195-199	transferrin	Rattus norvegicus	116-127
2222403-0	1990	The role of transferrin in the mechanism of cellular iron uptake.	Iron	53-57	transferrin	Homo sapiens	12-23
2224400-2	1990	Iron incorporation into erythroblasts was reduced in patients with ACD using a method based on incubation of erythroblasts with radiolabelled 59Fe-125I-transferrin.	Iron	0-4	transferrin	Homo sapiens	152-163
2224400-7	1990	These findings suggest that impaired iron uptake by erythroblasts, probably due to decreased transferrin binding to erythroblasts, might be a pathophysiological factor in ACD in RA.	Iron	37-41	transferrin	Homo sapiens	93-104
2213249-0	1990	Iron-induced metallothionein in chick liver: a rapid, route-dependent effect independent of zinc status.	Iron	0-4	metallothionein 4	Gallus gallus	13-28
2208657-0	1990	Colorimetry and constant-potential coulometry determinations of transferrin-bound iron, total iron-binding capacity, and total iron in serum containing iron-dextran, with use of sodium dithionite and alumina columns.	Iron	82-86	transferrin	Homo sapiens	64-75
2208657-3	1990	In addition, we have developed a procedure for determining transferrin-bound iron, total iron-binding capacity (TIBC), total iron, and dextran-bound iron with the Kodak Ektachem colorimetric system.	Iron	77-81	transferrin	Homo sapiens	59-70
2208657-5	1990	After the mixture is applied to an Ektachem slide, transferrin-bound iron is released at pH 4 and is detected together with the iron previously bound to dextran.	Iron	69-73	transferrin	Homo sapiens	51-62
2208657-7	1990	Transferrin-bound iron is determined by applying diluted serum without added ferric citrate to an alumina column and measuring the iron in the column eluate.	Iron	18-22	transferrin	Homo sapiens	0-11
2208657-7	1990	Transferrin-bound iron is determined by applying diluted serum without added ferric citrate to an alumina column and measuring the iron in the column eluate.	Iron	131-135	transferrin	Homo sapiens	0-11
2208657-8	1990	Dextran-bound iron is equivalent to the difference between total and transferrin-bound iron.	Iron	87-91	transferrin	Homo sapiens	69-80
2208657-9	1990	Using this method, we found that transferrin iron-binding sites are saturated in vitro by excess iron-dextran less efficiently than by ferric citrate.	Iron	45-49	transferrin	Homo sapiens	33-44
2228020-9	1990	In support of a dual effect of the drug is the finding that at 50 mumol/l, desferrioxamine-enhanced expression of the transferrin receptor occurred, an adaptive response made to intracellular iron depletion, while IL-2 receptor expression was inhibited.	Iron	192-196	transferrin	Homo sapiens	118-129
2123493-7	1990	Thus regulation of ferritin synthesis at the translational and transcriptional levels and by transferrin receptor mRNA abundance at the level of breakdown provide a coordinated mechanism for protecting cells against the effects of excess iron.	Iron	238-242	transferrin	Homo sapiens	93-104
2150666-1	1990	The immunoregulatory effect of non-transferrin-bound iron (Fe3+) on the proliferative and cytotoxic responses of normal human T lymphocytes was studied using a sensitive limit-dilution technique capable of detecting the responses of individual lymphocytes.	Iron	53-57	transferrin	Homo sapiens	35-46
2150666-7	1990	These data support the hypothesis that non-transferrin-bound iron has an immunoregulatory role in cell-mediated immunity.	Iron	61-65	transferrin	Homo sapiens	43-54
2213249-10	1990	Zn depletion eliminated the accumulation of hepatic Zn and MT protein following ip injection of Fe or endotoxin, but not of cadmium, despite marked elevation of hepatic MTmRNA.	Iron	96-98	metallothionein 4	Gallus gallus	59-61
2213249-11	1990	Our results demonstrate Fe injected into the body cavity of chicks results in a rapid induction of hepatic MT that, like endotoxin induction, is independent of dietary Zn status.	Iron	24-26	metallothionein 4	Gallus gallus	107-109
2213249-1	1990	The induction of hepatic metallothionein (MT) by the parenteral administration of iron was studied.	Iron	82-86	metallothionein 4	Gallus gallus	25-40
2213249-1	1990	The induction of hepatic metallothionein (MT) by the parenteral administration of iron was studied.	Iron	82-86	metallothionein 4	Gallus gallus	42-44
2213249-2	1990	Iron administered to chicks by intravenous or subcutaneous injection caused a 1.9-fold increase in hepatic MT.	Iron	0-4	metallothionein 4	Gallus gallus	107-109
2213249-5	1990	High ip doses of Fe resulted in a persistent depression in serum Zn and elevated MT and MTmRNA.	Iron	17-19	metallothionein 4	Gallus gallus	81-83
2213249-9	1990	The MT induction by Fe, as well as related depression in plasma Zn, was completely inhibited by actinomycin D.	Iron	20-22	metallothionein 4	Gallus gallus	4-6
2095546-1	1990	In 5 haemodialyzed patients with end-stage renal failure an effect of human recombinant erythropoietin (r-huEpo) on haemoglobin, haematocrit and iron metabolism was studied.	Iron	145-149	erythropoietin	Homo sapiens	88-102
2172968-1	1990	Iron-responsive elements (IREs) are stemloop structures found in the mRNAs encoding ferritin and the transferrin receptor.	Iron	0-4	transferrin	Homo sapiens	101-112
2172968-2	1990	These elements participate in the iron-induced regulation of the translation of ferritin and the stability of the transferrin receptor mRNA.	Iron	34-38	transferrin	Homo sapiens	114-125
2172968-4	1990	High-affinity binding is seen when cells are starved of iron and results in repression of ferritin translation and inhibition of transferrin receptor mRNA degradation.	Iron	56-60	transferrin	Homo sapiens	129-140
2095458-10	1990	In developing red cells, levels of ALAS are regulated by increased gene transcription and by a post-transcriptional mechanism, in which iron most probably controls translation of erythroid ALAS mRNA through an iron-responsive element identified in the 5" untranslated region of the mRNA.	Iron	136-140	5'-aminolevulinate synthase 1	Homo sapiens	35-39
2095458-10	1990	In developing red cells, levels of ALAS are regulated by increased gene transcription and by a post-transcriptional mechanism, in which iron most probably controls translation of erythroid ALAS mRNA through an iron-responsive element identified in the 5" untranslated region of the mRNA.	Iron	136-140	5'-aminolevulinate synthase 1	Homo sapiens	189-193
2095458-10	1990	In developing red cells, levels of ALAS are regulated by increased gene transcription and by a post-transcriptional mechanism, in which iron most probably controls translation of erythroid ALAS mRNA through an iron-responsive element identified in the 5" untranslated region of the mRNA.	Iron	210-214	5'-aminolevulinate synthase 1	Homo sapiens	35-39
2095458-10	1990	In developing red cells, levels of ALAS are regulated by increased gene transcription and by a post-transcriptional mechanism, in which iron most probably controls translation of erythroid ALAS mRNA through an iron-responsive element identified in the 5" untranslated region of the mRNA.	Iron	210-214	5'-aminolevulinate synthase 1	Homo sapiens	189-193
2091489-4	1990	Trace amounts of iron are quantitatively retained on naphthalene in the pH range 3.5-7.5 and at a flow-rate of 1-2 ml min-1.	Iron	17-21	CD59 molecule (CD59 blood group)	Homo sapiens	118-123
2207126-1	1990	A transferrin binding protein was isolated from normal rat placenta and from iron-deficient rat plasma using a human transferrin affinity column.	Iron	77-81	transferrin	Rattus norvegicus	2-13
2209603-1	1990	Receptor-mediated endocytosis and recycling of transferrin is partly inhibited by the ferrous iron chelator bipyridine, which almost completely blocks iron uptake.	Iron	94-98	transferrin	Homo sapiens	47-58
2257482-1	1990	Transferrin and its receptor are involved in the delivery of iron to most cells.	Iron	61-65	transferrin	Homo sapiens	0-11
2393846-5	1990	Thus, under very different culture conditions, gallium and iron appear to compete via the transferrin-transferrin receptor pathway for cellular uptake.	Iron	59-63	transferrin	Homo sapiens	90-101
2393846-5	1990	Thus, under very different culture conditions, gallium and iron appear to compete via the transferrin-transferrin receptor pathway for cellular uptake.	Iron	59-63	transferrin	Homo sapiens	102-113
2207126-6	1990	Immunoblotting of both normal and iron deficient rat plasma showed that the transferrin binding protein had a molecular mass of 85 kDa.	Iron	34-38	transferrin	Rattus norvegicus	76-87
1700672-3	1990	High concentrations of TNF were found in serum samples of patients with severe RA, who had increased erythrocyte sedimentation rate and serum alpha 2 macroglobulin, but decreased haemoglobin and serum iron concentrations.	Iron	201-205	tumor necrosis factor	Homo sapiens	23-26
2208733-3	1990	The role of transferrin in iron metabolism is evaluated, both with regard to iron uptake by transferrin as to iron uptake from transferrin by different cells.	Iron	27-31	transferrin	Homo sapiens	12-23
2168158-0	1990	Site-specific rate constants for iron removal from diferric transferrin by nitrilotris(methylenephosphonic acid) and pyrophosphate.	Iron	33-37	transferrin	Homo sapiens	60-71
2168158-1	1990	The kinetics of iron removal from human serum diferric transferrin by nitrilotris(methylenephosphonic acid) (NTP) and pyrophosphate (PPi) have been studied in 0.1 M, pH 7.4, N-(2-hydroxyethyl)piperazine-N"-2-ethanesulfonate buffer at 25 degrees C using urea/polyacrylamide gel electrophoresis.	Iron	16-20	transferrin	Homo sapiens	55-66
2168158-2	1990	The four microscopic rate constants required for a complete description of iron removal from the two transferrin metal-binding sites have been measured at 100 mM concentrations of NTP and PPi.	Iron	75-79	transferrin	Homo sapiens	101-112
2168158-4	1990	The results validate the use of cobalt-labeled transferrins as models for kinetic studies on iron removal from diferric transferrin.	Iron	93-97	transferrin	Homo sapiens	47-58
2208733-5	1990	Apart from its traditional role in iron metabolism, transferrin acts as a growth factor.	Iron	35-39	transferrin	Homo sapiens	52-63
2208733-11	1990	Hypotheses concerning the biochemical basis of this effect are presented and within this context a new hypothesis on the differential occupation of iron binding sites of serum transferrin is forwarded.	Iron	148-152	transferrin	Homo sapiens	176-187
2126294-5	1990	Control myocytes superfused with a physiological buffer or buffer containing purine and iron-loaded transferrin exhibited Ca2+ transients associated with spontaneous contractions.	Iron	88-92	transferrin	Rattus norvegicus	100-111
2117572-0	1990	Expression of Neisseria meningitidis iron-regulated outer membrane proteins, including a 70-kilodalton transferrin receptor, and their potential for use as vaccines.	Iron	37-41	transferrin	Homo sapiens	103-114
2117572-5	1990	Growth under conditions of iron limitation caused a several-fold increase in the amount of transferrin bound to the cell surface.	Iron	27-31	transferrin	Homo sapiens	91-102
2391604-5	1990	Progressively abnormal iron profiles were associated with higher glycosylated fetal hemoglobin values, greater degrees of macrosomia, increased hemoglobin and erythropoietin concentrations, and increased erythrocyte/storage iron ratios.	Iron	23-27	erythropoietin	Homo sapiens	159-173
2401848-0	1990	Influence of cellular iron status on the release of soluble transferrin receptor from human promyelocytic leukemic HL60 cells.	Iron	22-26	transferrin	Homo sapiens	60-71
2401848-2	1990	Because of the regulatory role of iron in transferrin receptor expression, we have now examined the relationship between iron and the release of soluble transferrin receptor from HL60 cells.	Iron	121-125	transferrin	Homo sapiens	153-164
2401848-9	1990	Our studies show that transferrin receptor release from HL60 cells changes during iron excess or iron deficiency and that these changes are the result of alterations in cell surface transferrin receptor density.	Iron	82-86	transferrin	Homo sapiens	22-33
2391604-6	1990	Erythropoietin concentrations were inversely linearly correlated with serum iron values (n = 32, r = -0.54; p = 0.003).	Iron	76-80	erythropoietin	Homo sapiens	0-14
1696948-5	1990	Since the recruitment of stored ferritin mRNA onto polyribosomes is seen when iron enters the cell, the effect of IL-1 beta on iron uptake was tested and was found to be unaffected by the lymphokine.	Iron	127-131	interleukin 1 beta	Homo sapiens	114-123
2238708-6	1990	The evidence presented in this paper supports a different mechanism involving chronic induction of the microsomal cytochrome P-450 system, mobilization of hepatocellular iron and associated oxidative stress.	Iron	170-174	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	114-130
2380200-1	1990	To investigate the regulation mechanism of the uptake of iron and heme iron by the cells and intracellular utilization of iron, we examined the interaction between iron uptake from transferrin and hemopexin-mediated uptake of heme by human leukemic U937 cells or HeLa cells.	Iron	57-61	transferrin	Homo sapiens	181-192
2380200-4	1990	Treatment of both species of cells with hemopexin led to a rapid decrease in iron uptake from transferrin in a hemopexin dose-dependent manner, and the decrease seen in case of treatment with hemin was less than that seen with hemopexin.	Iron	77-81	transferrin	Homo sapiens	94-105
2380200-5	1990	The decrease of iron uptake by hemopexin contributed to a decrease in cell surface transferrin receptors on hemopexin-treated cells.	Iron	16-20	transferrin	Homo sapiens	83-94
2380200-11	1990	The results suggest that iron released from heme down-regulates the expression of the transferrin receptors and iron uptake.	Iron	25-29	transferrin	Homo sapiens	86-97
2091905-1	1990	HLA-A,B antigens were typed in 15 patients with Hemoglobin H disease; 10 of them had iron overloading.	Iron	85-89	major histocompatibility complex, class I, A	Homo sapiens	0-7
2386793-9	1990	In contrast, iron-treated LDL exhibited a loss of the apo B-100 band and a decrease in the number of TNBS-reactive amino group.	Iron	13-17	apolipoprotein B	Homo sapiens	54-63
2376597-2	1990	Transferrin (TF) is a plasma protein that transports and is regulated by iron.	Iron	73-77	transferrin	Homo sapiens	0-11
2376597-2	1990	Transferrin (TF) is a plasma protein that transports and is regulated by iron.	Iron	73-77	transferrin	Homo sapiens	13-15
2376597-3	1990	The aim of this study was to characterize human TF gene sequences that respond in vivo to cellular signals affecting expression in various tissues and to iron administration.	Iron	154-158	transferrin	Homo sapiens	48-50
2376597-10	1990	Transgenic mouse lines carrying human TF chimeric genes will be useful models for analyzing the regulation of human transferrin by iron and for determining the molecular basis of transferrin regulation throughout mammalian development into the aging process.	Iron	131-135	transferrin	Homo sapiens	38-40
2376597-10	1990	Transgenic mouse lines carrying human TF chimeric genes will be useful models for analyzing the regulation of human transferrin by iron and for determining the molecular basis of transferrin regulation throughout mammalian development into the aging process.	Iron	131-135	transferrin	Homo sapiens	116-127
2382644-0	1990	Recombinant human erythropoietin and phlebotomy in the treatment of iron overload in chronic hemodialysis patients.	Iron	68-72	erythropoietin	Homo sapiens	18-32
2382644-6	1990	In patients with severe iron overload, changes in serum ferritin with erythropoietin treatment alone may not reflect true change in iron burden.	Iron	24-28	erythropoietin	Homo sapiens	70-84
2382644-7	1990	Use of high-dose erythropoietin and phlebotomy is an effective and safe (at least for 1 year) method of reducing iron overload in long-term hemodialysis patients.	Iron	113-117	erythropoietin	Homo sapiens	17-31
2164439-1	1990	We have shown that transferrin-gallium (Tf-Ga) blocks DNA synthesis through inhibition of cellular iron incorporation and a diminution in the activity of the iron-dependent M2 subunit of ribonucleotide reductase.	Iron	99-103	transferrin	Homo sapiens	19-30
2164439-1	1990	We have shown that transferrin-gallium (Tf-Ga) blocks DNA synthesis through inhibition of cellular iron incorporation and a diminution in the activity of the iron-dependent M2 subunit of ribonucleotide reductase.	Iron	158-162	transferrin	Homo sapiens	19-30
2118498-3	1990	The requirement of hybridoma growth for transferrin has been met by substituting the soluble organo-iron compound, sodium nitroprusside.	Iron	100-104	transferrin	Homo sapiens	40-51
2242219-1	1990	Choline dehydrogenase contains the prosthetic group FAD, non-haem iron and acid labile sulfur.	Iron	66-70	choline dehydrogenase	Rattus norvegicus	0-21
2375400-7	1990	In lungs pretreated with the iron binding protein transferrin the Kfc increased 0.31 +/- 0.11 and 0.19 +/- 0.03 ml.min-1.cmH2O-1.100 g lung tissue-1 following IR and t-buOOH challenge, respectively.	Iron	29-33	transferrin	Rattus norvegicus	50-61
2365686-0	1990	Nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake.	Iron	77-81	transferrin	Homo sapiens	18-29
2365686-9	1990	Functional studies indicated that these non-acylated mutant receptors were internalized efficiently and mediated iron uptake from human transferrin at a similar rate to that of wild type receptors.	Iron	113-117	transferrin	Homo sapiens	136-147
2383916-1	1990	The present study concerns the endotoxin neutralizing activity of human iron-free transferrin, and group-specific protein also called Gc-globulin.	Iron	72-76	transferrin	Homo sapiens	82-93
2272085-2	1990	Percentage saturation of transferrin with iron and the usual erythrocyte parameters of iron status were similar in both group of subjects.	Iron	42-46	transferrin	Homo sapiens	25-36
2383916-2	1990	Iron-free transferrin was used because former studies showed that the endotoxin binding capacity is restricted to apotransferrin.	Iron	0-4	transferrin	Homo sapiens	10-21
2364114-1	1990	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	transferrin	Homo sapiens	16-27
2365453-0	1990	Iron acquisition in Pasteurella haemolytica: expression and identification of a bovine-specific transferrin receptor.	Iron	0-4	serotransferrin	Bos taurus	96-107
2365453-4	1990	Iron-deficient cells from these strains expressed a binding activity, specific for bovine transferrin, that was regulated by the level of iron in the medium.	Iron	0-4	serotransferrin	Bos taurus	90-101
2365453-4	1990	Iron-deficient cells from these strains expressed a binding activity, specific for bovine transferrin, that was regulated by the level of iron in the medium.	Iron	138-142	serotransferrin	Bos taurus	90-101
2373481-8	1990	These results in a series of patients who have been followed for a median of 3 yr (range = 1 to 30 yr) validate the use of the hepatic iron index to discriminate hemochromatosis homozygotes from heterozygotes with raised levels of serum ferritin, transferrin saturation or both.	Iron	135-139	transferrin	Homo sapiens	247-258
2361941-10	1990	A region of homology with the cytochrome P-450s from various organisms was identified in the choP protein and may represent a region associated with a binding site for heme iron.	Iron	173-177	DNA damage inducible transcript 3	Homo sapiens	93-97
2364114-4	1990	The uptake of iron from transferrin occurred by at least two processes.	Iron	14-18	transferrin	Homo sapiens	24-35
2364114-7	1990	This process of iron uptake may be the dominant one at physiological serum transferrin concentrations.	Iron	16-20	transferrin	Homo sapiens	75-86
2357123-1	1990	Epoetin alfa: focus on iron management.	Iron	23-27	erythropoietin	Homo sapiens	0-7
2360638-2	1990	Intraperitoneal (ip) injection of chromium (Cr), managanese, and iron (Fe) caused a much greater increase in hepatic MT (10.2-, 9.0-, and 6.8-fold) compared with cobalt and nickel (2.5- and 2.9-fold); thus not all transition metals are effective.	Iron	65-69	metallothionein 4	Gallus gallus	117-119
2360638-2	1990	Intraperitoneal (ip) injection of chromium (Cr), managanese, and iron (Fe) caused a much greater increase in hepatic MT (10.2-, 9.0-, and 6.8-fold) compared with cobalt and nickel (2.5- and 2.9-fold); thus not all transition metals are effective.	Iron	71-73	metallothionein 4	Gallus gallus	117-119
2360638-4	1990	Small organic complexes of Fe (ferrous gluconate or lactate, 6.2-fold) caused significantly greater accumulation of hepatic MT than ferric dextran (1.4-fold), a large organic aggregate.	Iron	27-29	metallothionein 4	Gallus gallus	124-126
2383057-6	1990	In the patients with adequate iron stores, but not in the iron depleted patients, there was a tendency for serum erythropoietin concentrations to correlate positively both with C reactive protein and erythrocyte sedimentation rate.	Iron	30-34	erythropoietin	Homo sapiens	113-127
2357123-2	1990	Stimulation of erythropoiesis by Epoetin alfa causes an increased demand for iron to facilitate hemoglobin synthesis.	Iron	77-81	erythropoietin	Homo sapiens	33-40
2357123-3	1990	This article outlines how nephrology nurses can monitor and manage iron levels during Epoetin alfa therapy; including both iron-deficient and iron overloaded patients.	Iron	67-71	erythropoietin	Homo sapiens	86-93
1972175-7	1990	Typing for the HLA-A, -B, -C and -DR loci showed that the HLA-A3 allele (frequency 0.6471 and relative risk 4.4) was the only independent marker for the iron-loading gene in this asymptomatic population.	Iron	153-157	major histocompatibility complex, class I, A	Homo sapiens	15-36
2375965-3	1990	The increased mucosal uptake of ionized iron was not the result of increased adsorption, but instead appeared related to a metabolically active uptake process, whereas the increased mucosal uptake of transferrin iron was associated with increased numbers of mucosal cell membrane transferrin receptors.	Iron	212-216	transferrin	Rattus norvegicus	200-211
2375965-6	1990	Iron loading of the mucosal cell from circulating plasma transferrin was proportionate to the plasma iron concentration.	Iron	0-4	transferrin	Rattus norvegicus	57-68
2375965-7	1990	Mucosal iron content was the composite of iron loading from the lumen and loading from plasma transferrin versus release of iron into the body.	Iron	8-12	transferrin	Rattus norvegicus	94-105
16348205-4	1990	The rate of anaerobic S oxidation with Fe was equal to the aerobic oxidation rate in SM-1, SM-3, SM-4, and SM-5, but was only one-half or less that in Tf-1, Tf-2, SM-2, and SM-8.	Iron	39-41	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	163-167
16348205-5	1990	Transition from growth on Fe to that on S produced cells with relatively undiminished Fe oxidation activities and increased S oxidation (both aerobic and anaerobic) activities in Tf-2, SM-4, and SM-5, whereas it produced cells with dramatically reduced Fe oxidation and anaerobic S oxidation activities in Tf-1, SM-1, SM-2, SM-3, and SM-8.	Iron	26-28	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	312-316
16348205-5	1990	Transition from growth on Fe to that on S produced cells with relatively undiminished Fe oxidation activities and increased S oxidation (both aerobic and anaerobic) activities in Tf-2, SM-4, and SM-5, whereas it produced cells with dramatically reduced Fe oxidation and anaerobic S oxidation activities in Tf-1, SM-1, SM-2, SM-3, and SM-8.	Iron	26-28	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	318-322
2362400-4	1990	The fact that iron/transferrin ratios in urine and serum were frequently different, sometimes higher other times lower, documents that iron and transferrin can be dissociated in tubule fluid and handled differently in regards to tubule uptake.	Iron	14-18	transferrin	Homo sapiens	144-155
2186090-2	1990	Insorption into absorptive cells of luminal iron bound to transferrin via receptor-mediated endocytosis has been hypothesized, but transferrin and transferrin receptor are absent in apical microvillous brush borders of small bowel biopsies taken from fasted patients and normal volunteers.	Iron	44-48	transferrin	Homo sapiens	58-69
2362400-4	1990	The fact that iron/transferrin ratios in urine and serum were frequently different, sometimes higher other times lower, documents that iron and transferrin can be dissociated in tubule fluid and handled differently in regards to tubule uptake.	Iron	135-139	transferrin	Homo sapiens	19-30
2362400-8	1990	Kidney iron concentration does not correlate with tubule fluid iron content but can be prevented from increasing by systemic iron and/or transferrin depletion.	Iron	7-11	transferrin	Homo sapiens	137-148
2362400-9	1990	This suggests that iron enters the distal tubule cells with transferrin via its receptors from the basolateral side of the distal tubule cells.	Iron	19-23	transferrin	Homo sapiens	60-71
2349215-8	1990	We enhanced the rate of gene delivery by (i) increasing the transferrin receptor density through treatment of the cells with the cell-permeable iron chelator desferrioxamine, (ii) interfering with the synthesis of heme with succinyl acetone treatment, or (iii) stimulating the degradation of heme with cobalt chloride treatment.	Iron	144-148	transferrin	Homo sapiens	60-71
2350350-2	1990	We recently observed that TNF leads to an increase in the synthesis of the heavy chain of ferritin, suggesting that TNF may be involved in iron homeostasis (Torti et al.	Iron	139-143	tumor necrosis factor	Homo sapiens	26-29
2349215-2	1990	By coupling the natural iron-delivery protein transferrin to the DNA-binding polycations polylysine or protamine, we have created protein conjugates that bind nucleic acids and carry them into the cell during the normal transferrin cycle [Wagner, E., Zenke, M., Cotten, M., Beug, H. &amp; Birnstiel, M. L. (1990) Proc.	Iron	24-28	transferrin	Homo sapiens	46-57
2349215-2	1990	By coupling the natural iron-delivery protein transferrin to the DNA-binding polycations polylysine or protamine, we have created protein conjugates that bind nucleic acids and carry them into the cell during the normal transferrin cycle [Wagner, E., Zenke, M., Cotten, M., Beug, H. &amp; Birnstiel, M. L. (1990) Proc.	Iron	24-28	transferrin	Homo sapiens	220-231
2350350-2	1990	We recently observed that TNF leads to an increase in the synthesis of the heavy chain of ferritin, suggesting that TNF may be involved in iron homeostasis (Torti et al.	Iron	139-143	tumor necrosis factor	Homo sapiens	116-119
2116350-1	1990	Neisseria meningitidis is able to chelate iron from human transferrin (HTF), the main sequestrator of extracellular iron in vivo.	Iron	42-46	transferrin	Homo sapiens	58-69
2158987-1	1990	Iron binding to transferrin and lactoferrin requires a synergistic anion, which is carbonate in vivo.	Iron	0-4	transferrin	Homo sapiens	16-27
2158987-3	1990	To understand better the iron-carbonate interaction, experiments were performed with iron(III) and copper(II) complexes of human milk lactoferrin and serum transferrin with carbon-13-labeled carbonate.	Iron	25-29	transferrin	Homo sapiens	156-167
2227617-1	1990	Iron transport from the mother to the fetus is mediated by transferrin receptors located at the maternofetal interface of the placenta.	Iron	0-4	transferrin	Homo sapiens	59-70
2227617-2	1990	Transferrin receptors bind iron-loaded transferrin molecules from the maternal plasma, thus allowing iron uptake by trophoblastic cells which then deliver the metal to the fetal plasma.	Iron	27-31	transferrin	Homo sapiens	0-11
2227617-2	1990	Transferrin receptors bind iron-loaded transferrin molecules from the maternal plasma, thus allowing iron uptake by trophoblastic cells which then deliver the metal to the fetal plasma.	Iron	27-31	transferrin	Homo sapiens	39-50
2227617-2	1990	Transferrin receptors bind iron-loaded transferrin molecules from the maternal plasma, thus allowing iron uptake by trophoblastic cells which then deliver the metal to the fetal plasma.	Iron	101-105	transferrin	Homo sapiens	0-11
2363505-0	1990	A direct method for quantification of non-transferrin-bound iron.	Iron	60-64	transferrin	Homo sapiens	42-53
2363505-1	1990	A direct method for quantification of non-transferrin-bound iron has been developed.	Iron	60-64	transferrin	Homo sapiens	42-53
2363505-3	1990	Iron bound to transferrin, ferritin, desferrioxamine, and its metabolites is unaffected.	Iron	0-4	transferrin	Homo sapiens	14-25
2116350-1	1990	Neisseria meningitidis is able to chelate iron from human transferrin (HTF), the main sequestrator of extracellular iron in vivo.	Iron	116-120	transferrin	Homo sapiens	58-69
2227617-2	1990	Transferrin receptors bind iron-loaded transferrin molecules from the maternal plasma, thus allowing iron uptake by trophoblastic cells which then deliver the metal to the fetal plasma.	Iron	101-105	transferrin	Homo sapiens	39-50
2227617-7	1990	The amount of transferrin receptors in the placenta was found to be inversely related to the amount of non-haem iron (r = 0.64; p less than 0.025).	Iron	112-116	transferrin	Homo sapiens	14-25
2227617-9	1990	We conclude that placental non-haem iron, which represents a storage form of this element, is likely to play a regulatory role in the expression of transferrin receptors, and consequently in the process of iron uptake by the placenta.	Iron	36-40	transferrin	Homo sapiens	148-159
2333290-4	1990	These modified transferrin molecules maintain their ability to bind their cognate receptor and to mediate efficient iron transport into the cell.	Iron	116-120	transferrin	Homo sapiens	15-26
2227617-9	1990	We conclude that placental non-haem iron, which represents a storage form of this element, is likely to play a regulatory role in the expression of transferrin receptors, and consequently in the process of iron uptake by the placenta.	Iron	206-210	transferrin	Homo sapiens	148-159
2204616-5	1990	The properties of rat liver catalase and those of the recombinant were similar with respect to molecular mass, catalytic properties, profiles of absorption spectra, and iron contents.	Iron	169-173	catalase	Rattus norvegicus	28-36
15539210-3	1990	It is known that iron enters other cells via transferrin receptor-mediated endocytosis.	Iron	17-21	transferrin	Rattus norvegicus	45-56
15539210-10	1990	The presence of transferrin receptors in normal lactating rat mammary tissue is likely to explain iron transport into mammary tissue for both cellular metabolism and milk iron secretion.	Iron	98-102	transferrin	Rattus norvegicus	16-27
15539210-10	1990	The presence of transferrin receptors in normal lactating rat mammary tissue is likely to explain iron transport into mammary tissue for both cellular metabolism and milk iron secretion.	Iron	171-175	transferrin	Rattus norvegicus	16-27
2157501-0	1990	Release of iron from diferric transferrin in the presence of rat liver plasma membranes: no evidence of a plasma membrane diferric transferrin reductase.	Iron	11-15	transferrin	Rattus norvegicus	30-41
2330032-1	1990	Proteins of the transferrin family, which contains serum transferrin and lactoferrin, control iron levels in higher animals through their very tight (Kapp approximately 10(20)) but reversible binding of iron.	Iron	94-98	transferrin	Homo sapiens	16-27
2330032-1	1990	Proteins of the transferrin family, which contains serum transferrin and lactoferrin, control iron levels in higher animals through their very tight (Kapp approximately 10(20)) but reversible binding of iron.	Iron	94-98	transferrin	Homo sapiens	57-68
2330032-1	1990	Proteins of the transferrin family, which contains serum transferrin and lactoferrin, control iron levels in higher animals through their very tight (Kapp approximately 10(20)) but reversible binding of iron.	Iron	203-207	transferrin	Homo sapiens	16-27
2330032-1	1990	Proteins of the transferrin family, which contains serum transferrin and lactoferrin, control iron levels in higher animals through their very tight (Kapp approximately 10(20)) but reversible binding of iron.	Iron	203-207	transferrin	Homo sapiens	57-68
2330032-3	1990	Crystallographic studies of human lactoferrin and rabbit serum transferrin in their iron-bound forms have characterized their binding sites and protein structure.	Iron	84-88	transferrin	Homo sapiens	63-74
2157501-1	1990	The transfer of iron from diferric transferrin to bathophenanthroline disulfonate was measured under varying conditions by spectrophotometry and EPR spectroscopy.	Iron	16-20	transferrin	Rattus norvegicus	35-46
2157501-2	1990	Intact rat hepatocytes efficiently mediated the transfer of iron from human diferric transferrin to bathophenanthroline disulfonate.	Iron	60-64	transferrin	Homo sapiens	85-96
2157501-6	1990	Our results, together with theoretical considerations, show that the ability (or inability) of intact cells or isolated plasma membranes to facilitate the transfer of iron from transferrin to strong diferric iron chelators does not allow interferences about the existence of an iron reduction step as part of the process of cellular uptake of iron from transferrin.	Iron	167-171	transferrin	Rattus norvegicus	177-188
2327986-6	1990	It was observed that the substitution of tyrosine-20 with cysteine caused a 60% inhibition of the rate of iron accumulation by cells incubated with [59Fe]diferric transferrin.	Iron	106-110	transferrin	Homo sapiens	163-174
2333967-0	1990	Iron uptake from transferrin and lactoferrin by rat intestinal brush-border membrane vesicles.	Iron	0-4	transferrin	Rattus norvegicus	17-28
2338275-10	1990	The line broadening correlated with the degree of iron overload suggesting the potential use of P-31 magnetic resonance spectroscopy for measuring liver iron.	Iron	50-54	ATPase H+ transporting V1 subunit E1	Homo sapiens	96-100
2344468-0	1990	Resonance Raman enhancement of phenyl ring vibrational modes in phenyl iron complex of myoglobin.	Iron	71-75	myoglobin	Equus caballus	87-96
2179037-0	1990	Differential expression of transferrin receptor in duodenal mucosa in iron overload.	Iron	70-74	transferrin	Homo sapiens	27-38
2179037-5	1990	In the present study we used immunohistochemical techniques to study transferrin-receptor expression in the gastrointestinal epithelium in normal subjects and patients with iron overload.	Iron	173-177	transferrin	Homo sapiens	69-80
2186821-3	1990	In vivo reticulocyte uptake and release of labelled diferric transferrin injected in the iron-deficient rat averaged 1.7 min.	Iron	89-93	transferrin	Rattus norvegicus	61-72
2338275-10	1990	The line broadening correlated with the degree of iron overload suggesting the potential use of P-31 magnetic resonance spectroscopy for measuring liver iron.	Iron	153-157	ATPase H+ transporting V1 subunit E1	Homo sapiens	96-100
2126342-2	1990	The rat transferrin receptor nucleotide sequence was shown to be 82% similar to the human transferrin receptor sequence over the amino acid coding region and over 90% similar in the sequences known to be responsible for iron regulation in the human mRNA.	Iron	220-224	transferrin	Rattus norvegicus	8-19
1692725-9	1990	The pathophysiological implications of these facts are discussed in relation to the structural and/or metabolic activities of fatty acids and iron, the ligands carried by AFP and Tf, respectively.	Iron	142-146	alpha fetoprotein	Homo sapiens	171-174
1969510-5	1990	Transferrin iron saturation was higher in the Alzheimer (58.9%) and Down syndrome groups (81.6%) than in the controls (39.0%) or stroke dementia patients (33.4%).	Iron	12-16	transferrin	Homo sapiens	0-11
2156853-1	1990	Iron regulates the synthesis of two proteins critical for iron metabolism, ferritin and the transferrin receptor, through novel mRNA/protein interactions.	Iron	0-4	transferrin	Homo sapiens	92-103
2156853-1	1990	Iron regulates the synthesis of two proteins critical for iron metabolism, ferritin and the transferrin receptor, through novel mRNA/protein interactions.	Iron	58-62	transferrin	Homo sapiens	92-103
2156853-2	1990	The mRNA regulatory sequence (iron-responsive element (IRE)) occurs in the 5"-untranslated region of all ferritin mRNAs and is repeated as five variations in the 3"-untranslated region of transferrin receptor mRNA.	Iron	30-34	transferrin	Homo sapiens	188-199
2156853-9	1990	Concerted regulation by iron of ferritin and transferrin receptor mRNAs may also define a more general strategy for using common mRNA sequences to coordinate the synthesis of metabolically related proteins.	Iron	24-28	transferrin	Homo sapiens	45-56
2157191-1	1990	A post-transcriptional regulatory protein, termed iron regulatory factor (IRF), that binds specifically to the iron-responsive elements of ferritin and transferrin receptor mRNA, has recently been identified in the cytoplasm of human and mouse cells.	Iron	50-54	transferrin	Homo sapiens	152-163
2310774-2	1990	The promotion of myogenesis requires transferrin (Tf) which transports Fe to the cells.	Iron	71-73	transferrin	Homo sapiens	37-48
2310774-2	1990	The promotion of myogenesis requires transferrin (Tf) which transports Fe to the cells.	Iron	71-73	transferrin	Homo sapiens	50-52
2334682-4	1990	The C zeta H proton of the Phe CD4 was found to move toward the iron of the heme by approximately 4 A relative to the position of sperm whale MbCO, requiring minimally a 3-A movement of the CD helical backbone.	Iron	64-68	T-cell surface glycoprotein CD4	Physeter catodon	31-34
1692725-9	1990	The pathophysiological implications of these facts are discussed in relation to the structural and/or metabolic activities of fatty acids and iron, the ligands carried by AFP and Tf, respectively.	Iron	142-146	transferrin	Homo sapiens	179-181
2307125-4	1990	Tf receptor expression increases during iron depletion and decreases with iron supplementation; the number of Tf receptors was also inversely related to both cell density and the rate of cell proliferation in vitro.	Iron	40-44	transferrin	Rattus norvegicus	0-2
2156501-2	1990	The recent determination by X-ray diffraction of the tridimensional structure of human lactotransferrin has underlined the presence of two lobes, each composed of two domains, I and II, as well as the involvement of five ligands in the binding of iron.	Iron	247-251	lactotransferrin	Homo sapiens	87-103
2137090-14	1990	The finding may provide a molecular basis for transferrin binding to liver endothelium and may explain the subsequent transendothelial transport of iron-transferrin complexes into the liver.	Iron	148-152	transferrin	Homo sapiens	46-57
2137090-14	1990	The finding may provide a molecular basis for transferrin binding to liver endothelium and may explain the subsequent transendothelial transport of iron-transferrin complexes into the liver.	Iron	148-152	transferrin	Homo sapiens	153-164
2312055-11	1990	Immunohistochemistry showed decreased parenchymal but increased reticuloendothelial transferrin receptor expression with iron load.	Iron	121-125	transferrin	Rattus norvegicus	84-95
2312055-14	1990	These findings support down-regulation of parenchymal transferrin receptor resulting from iron storage.	Iron	90-94	transferrin	Rattus norvegicus	54-65
2342475-8	1990	These studies demonstrate that germ cell secretions may interact with Sertoli cells to specifically increase the level of transferrin mRNA and that this interaction may be a mechanism by which germ cells regulate the flow of iron across the seminiferous epithelium.	Iron	225-229	transferrin	Rattus norvegicus	122-133
1366591-3	1990	Another iron-binding protein, transferrin, stimulated proliferation of HB4C5 cells as well as lactoferrin, but its stimulatory effect on IgM production was negligible.	Iron	8-12	transferrin	Homo sapiens	30-41
2298364-2	1990	A combination of biochemical quantitation and immunohistochemistry has been used to examine in detail transferrin receptor distribution and expression in the rat small intestine and its relationship to iron absorption.	Iron	202-206	transferrin	Rattus norvegicus	102-113
2298364-6	1990	Dietary or parenteral iron loading of animals produced a significant decline in transferrin binding, whereas binding was increased in iron deficiency.	Iron	22-26	transferrin	Rattus norvegicus	80-91
2298364-9	1990	These data indicate that intestinal transferrin receptors may be regulated by body iron stores but suggest that they are not directly involved in iron absorption.	Iron	83-87	transferrin	Rattus norvegicus	36-47
2307125-4	1990	Tf receptor expression increases during iron depletion and decreases with iron supplementation; the number of Tf receptors was also inversely related to both cell density and the rate of cell proliferation in vitro.	Iron	74-78	transferrin	Rattus norvegicus	0-2
2307125-7	1990	Decreases in the incorporation of [3H] thymidine into DNA were also noted in osteoblast-like cells incubated for 48 h with 3 microM partially saturated iron Tf or gallium Tf.	Iron	152-156	transferrin	Rattus norvegicus	157-159
2105943-0	1990	Characterization of a transferrin-independent uptake system for iron in HeLa cells.	Iron	64-68	transferrin	Homo sapiens	22-33
2368186-5	1990	The SOD activity in gastric juice can be decreased by adding antacids and Fe ions.	Iron	74-76	superoxide dismutase 1	Homo sapiens	4-7
2105943-3	1990	Uptake of non-transferrin (non-Tf) iron was transferrin-independent because of the fact that uptake occurred at pH 5.5, a pH at which transferrin binds iron poorly and at which transferrin is not internalized by cells.	Iron	35-39	transferrin	Homo sapiens	14-25
2105943-3	1990	Uptake of non-transferrin (non-Tf) iron was transferrin-independent because of the fact that uptake occurred at pH 5.5, a pH at which transferrin binds iron poorly and at which transferrin is not internalized by cells.	Iron	35-39	transferrin	Homo sapiens	44-55
2105943-3	1990	Uptake of non-transferrin (non-Tf) iron was transferrin-independent because of the fact that uptake occurred at pH 5.5, a pH at which transferrin binds iron poorly and at which transferrin is not internalized by cells.	Iron	35-39	transferrin	Homo sapiens	44-55
2105943-3	1990	Uptake of non-transferrin (non-Tf) iron was transferrin-independent because of the fact that uptake occurred at pH 5.5, a pH at which transferrin binds iron poorly and at which transferrin is not internalized by cells.	Iron	35-39	transferrin	Homo sapiens	44-55
2105943-4	1990	Uptake of non-Tf iron was less affected than uptake of transferrin iron by 1) exposure of cells to trypsin, a maneuver that cleaves Tf receptors, or 2) incubation of cells with phenylarsine oxide, an agent that inhibits both fluid- and receptor-mediated internalization.	Iron	67-71	transferrin	Homo sapiens	55-66
2105943-6	1990	Uptake of non-Tf iron could be partially blocked by Cu2+ in a dose-dependent manner, while the accumulation of transferrin-bound iron was unaffected by Cu2+.	Iron	129-133	transferrin	Homo sapiens	111-122
2159343-6	1990	While in state I the structure of cytochrome c is essentially the same as in solution, state II is characterized by a structural rearrangement of the heme pocket, leading to a weakening of the axial iron-methionine bond and an opening of the heme crevice which is situated in the center of the binding domain for cytochrome oxidase.	Iron	199-203	cytochrome c, somatic	Homo sapiens	34-46
2310376-3	1990	These studies examined the effects of various inhibitors on receptor-mediated transferrin iron delivery in order to define critical steps and events necessary to maintain the functional integrity of the pathway.	Iron	90-94	transferrin	Rattus norvegicus	78-89
2310376-4	1990	Dansylcadaverine inhibited iron uptake by blocking exocytic release of transferrin and return of receptors to the cell surface, but did not affect transferrin endocytosis; this action served to deplete the surface pool of transferrin receptors, leading to shutdown of iron uptake.	Iron	27-31	transferrin	Rattus norvegicus	71-82
2154270-5	1990	When iron-poor lactoferrin was present during incubation with myeloperoxidase, 88% of the released 59Fe was precipitated with anti-lactoferrin antiserum, indicating that it was lactoferrin-bound.	Iron	5-9	myeloperoxidase	Homo sapiens	62-77
2242107-4	1990	The serum diagnosis of iron deficiency was accepted on the basis of the following: iron less than 11 mumol/L, total iron-binding capacity (TIBC) greater than 45 mumol/L, transferrin saturation (%Sat) less than 0.20, and ferritin less than 13 micrograms/L for females and less than 25 micrograms/L for males.	Iron	23-27	transferrin	Homo sapiens	170-181
2110858-2	1990	Consistent with the receptor specificity, iron-deficient bacteria were only capable of utilizing transferrin from the host as a source of iron for growth.	Iron	42-46	transferrin	Homo sapiens	97-108
2318295-3	1990	However reticulocytes, treated with succinylacetone or rotenone and taking up iron from transferrin, accumulated iron in nonhaem cytosolic proteins and in mitochondria and not in the low MW pool.	Iron	78-82	transferrin	Homo sapiens	88-99
2318295-3	1990	However reticulocytes, treated with succinylacetone or rotenone and taking up iron from transferrin, accumulated iron in nonhaem cytosolic proteins and in mitochondria and not in the low MW pool.	Iron	113-117	transferrin	Homo sapiens	88-99
2318987-10	1990	Intravenous iron treatment merits further evaluation, particularly with the advent of erythropoietin treatment, which requires continuously available iron.	Iron	12-16	erythropoietin	Homo sapiens	86-100
2318987-10	1990	Intravenous iron treatment merits further evaluation, particularly with the advent of erythropoietin treatment, which requires continuously available iron.	Iron	150-154	erythropoietin	Homo sapiens	86-100
2156334-0	1990	Pyrophosphate-loaded hepatocytes show increased iron uptake from transferrin.	Iron	48-52	transferrin	Homo sapiens	65-76
2156334-4	1990	Compared to control cells, pyrophosphate-loaded hepatocytes showed an approximately 70% increase in iron accumulation from transferrin.	Iron	100-104	transferrin	Homo sapiens	123-134
2333585-5	1990	The decrease of serum iron, transferrin saturation index and ferritin in spite of oral iron therapy was striking.	Iron	87-91	transferrin	Homo sapiens	28-39
2302189-0	1990	Delivery of iron to human cells by bovine transferrin.	Iron	12-16	serotransferrin	Bos taurus	42-53
2154196-0	1990	IFN-gamma-activated macrophages: detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and non-heme iron proteins.	Iron	144-148	interferon gamma	Mus musculus	0-9
2154196-1	1990	Interferon-gamma induces the L-Arginine-dependent pathway that leads to the formation of nitrogen oxides in murine macrophages with subsequent inhibition of mitochondrial non-heme iron-dependent enzymes.	Iron	180-184	interferon gamma	Mus musculus	0-16
2154196-3	1990	In IFN-gamma-activated macrophages, we observed the appearance of a signal in the g = 2.04 region which is consistent with that given by nitrosyl-iron-sulfur complexes.	Iron	146-150	interferon gamma	Mus musculus	3-12
2120888-2	1990	Spectroscopic data suggested that such mixed complexes formed when pyrophosphate-Fe and acetohydroxamate-Fe were added to apotransferrin: the initial species had a different absorbance maximum than the final transferrin-iron complex.	Iron	81-83	transferrin	Homo sapiens	125-136
1967865-7	1990	Further on, diferric transferrin was preferentially used in order to abolish variation due to iron saturation.	Iron	94-98	transferrin	Homo sapiens	21-32
2183049-10	1990	Iron, which is essential for amastigote growth, thus appears to be delivered to T. cruzi amastigotes by transferrin receptor-mediated endocytosis.	Iron	0-4	transferrin	Homo sapiens	104-115
2120888-2	1990	Spectroscopic data suggested that such mixed complexes formed when pyrophosphate-Fe and acetohydroxamate-Fe were added to apotransferrin: the initial species had a different absorbance maximum than the final transferrin-iron complex.	Iron	105-107	transferrin	Homo sapiens	125-136
2120888-2	1990	Spectroscopic data suggested that such mixed complexes formed when pyrophosphate-Fe and acetohydroxamate-Fe were added to apotransferrin: the initial species had a different absorbance maximum than the final transferrin-iron complex.	Iron	220-224	transferrin	Homo sapiens	125-136
1982834-2	1990	Monitoring serum iron level during EPO therapy is essential.	Iron	17-21	erythropoietin	Homo sapiens	35-38
2094143-1	1990	The influence of maternal storage iron and placental iron levels on the storage iron and serum transferrin levels in newborns, placental non-haem iron, serum ferritin and transferrin concentrations was studied in 72 mothers and their singleton healthy newborns following uncomplicated pregnancies.	Iron	53-57	transferrin	Homo sapiens	95-106
2094143-1	1990	The influence of maternal storage iron and placental iron levels on the storage iron and serum transferrin levels in newborns, placental non-haem iron, serum ferritin and transferrin concentrations was studied in 72 mothers and their singleton healthy newborns following uncomplicated pregnancies.	Iron	53-57	transferrin	Homo sapiens	95-106
2094143-1	1990	The influence of maternal storage iron and placental iron levels on the storage iron and serum transferrin levels in newborns, placental non-haem iron, serum ferritin and transferrin concentrations was studied in 72 mothers and their singleton healthy newborns following uncomplicated pregnancies.	Iron	53-57	transferrin	Homo sapiens	95-106
2073459-0	1990	Uptake and intracellular distribution of iron from transferrin and chelators in erythroid cells.	Iron	41-45	transferrin	Homo sapiens	51-62
2085692-8	1990	It is possible to follow the route of internalization of vitellogenin-iron conjugates via coated pits, coated vesicles, uncoated vesicles, tubular endosomes, multivesicular endosomes, and light primordial yolk platelets.	Iron	70-74	a1-a	Xenopus laevis	57-69
2073459-4	1990	Several chelators could probably substitute for transferrin and be used to probe metabolic events subsequent to iron removal from transferrin.	Iron	112-116	transferrin	Homo sapiens	130-141
2073459-5	1990	Two chelators which were excellent iron donors were also found to cause considerable inhibition of iron incorporation into haem from transferrin.	Iron	35-39	transferrin	Homo sapiens	133-144
2073459-5	1990	Two chelators which were excellent iron donors were also found to cause considerable inhibition of iron incorporation into haem from transferrin.	Iron	99-103	transferrin	Homo sapiens	133-144
2138989-1	1990	It has been demonstrated that under iron-restricted conditions Bordetella pertussis can obtain iron from iron-saturated human transferrin.	Iron	36-40	transferrin	Homo sapiens	126-137
2153031-0	1990	Structural characterization of the isoenzymatic forms of human myeloperoxidase: evaluation of the iron-containing prosthetic group.	Iron	98-102	myeloperoxidase	Homo sapiens	63-78
2286062-2	1990	A comparison of the chemical and physical properties of the iron transport protein transferrin, purified from the following seventeen animal sera, is reported; human, rhesus monkey, dog, cat, rabbit, guinea pig, mouse, rat, cow, sheep, goat, horse, pig, turkey, duck, turtle and rattlesnake.	Iron	60-64	transferrin	Homo sapiens	83-94
2328566-8	1990	A role for transferrin in the uptake of dietary iron by the gastrointestinal tract is proposed.	Iron	48-52	transferrin	Homo sapiens	11-22
2303008-13	1990	Thus, comparatively less increase in CA and GP activities produces a deficiency of these two enzymes in the iron (ipsilateral) focus.	Iron	108-112	catalase	Rattus norvegicus	37-39
2138989-1	1990	It has been demonstrated that under iron-restricted conditions Bordetella pertussis can obtain iron from iron-saturated human transferrin.	Iron	95-99	transferrin	Homo sapiens	126-137
2138989-1	1990	It has been demonstrated that under iron-restricted conditions Bordetella pertussis can obtain iron from iron-saturated human transferrin.	Iron	95-99	transferrin	Homo sapiens	126-137
2138989-2	1990	Direct contact between B. pertussis and transferrin was not required as B. pertussis was able to acquire iron from transferrin when they were separated by a dialysis membrane.	Iron	105-109	transferrin	Homo sapiens	115-126
2097283-2	1990	In the presence of type I substrate n-heptane, the methanol induced spectrum disappears without detectable effects of interaction suggesting that methanol is a very weak ligand for heme iron of cytochrome P-450.	Iron	186-190	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	194-210
2323583-2	1990	Immediately after the infarction mean ferritin levels were significantly higher, whereas iron levels and iron saturation of transferrin were significantly lower in cases than in controls.	Iron	105-109	transferrin	Homo sapiens	124-135
2210558-0	1990	[Lactoferrin and transferrin--iron-binding proteins in physiological and pathological vitreous bodies].	Iron	30-34	transferrin	Homo sapiens	17-28
2170242-3	1990	In this investigation the role of hepatic aldehyde oxidase in the mobilization of catalytic iron from ferritin was studied in vitro.	Iron	92-96	aldehyde oxidase 1	Homo sapiens	42-58
2170242-4	1990	Iron mobilization due to the metabolism of ethanol to acetaldehyde by alcohol dehydrogenase was increased 100% by the addition of aldehyde oxidase.	Iron	0-4	aldehyde oxidase 1	Homo sapiens	130-146
2170242-6	1990	Mobilization of iron due to acetaldehyde metabolism by aldehyde oxidase was completely inhibited by superoxide dismutase but not by catalase suggesting that superoxide radicals mediate mobilization.	Iron	16-20	aldehyde oxidase 1	Homo sapiens	55-71
2170242-7	1990	Acetaldehyde-aldehyde oxidase mediated reduction of ferritin iron was facilitated by incubation with menadione, an electron acceptor for aldehyde oxidase.	Iron	61-65	aldehyde oxidase 1	Homo sapiens	13-29
2170242-7	1990	Acetaldehyde-aldehyde oxidase mediated reduction of ferritin iron was facilitated by incubation with menadione, an electron acceptor for aldehyde oxidase.	Iron	61-65	aldehyde oxidase 1	Homo sapiens	137-153
2170242-8	1990	Mobilization of ferritin iron due to the metabolism of acetaldehyde by aldehyde oxidase may be a fundamental mechanism of alcohol-induced liver injury.	Iron	25-29	aldehyde oxidase 1	Homo sapiens	71-87
2323583-7	1990	An increased uptake of iron in the reticulo-endothelial system for synthesis of ferritin, may account for the lowered serum iron level and the iron saturation of transferrin.	Iron	23-27	transferrin	Homo sapiens	162-173
2130296-0	1990	Recombinant erythropoietin reverses polymorphonuclear granulocyte dysfunction in iron-overloaded dialysis patients.	Iron	81-85	erythropoietin	Homo sapiens	12-26
2328142-6	1990	It is concluded from these results that there are Tf-receptors in the liver cell membrane to which iron transferrin may bind.	Iron	99-103	transferrin	Rattus norvegicus	104-115
2312587-1	1990	A copper slug heated with a soldering iron was used to produce full- and partial-thickness burns on the backs of mice.	Iron	38-42	snail family zinc finger 2	Mus musculus	9-13
27457048-5	1990	Uptake of iron and the cellular ferritin content also decreased by 50% when incubated with 10(4)U/ml of IFN-alpha.	Iron	10-14	interferon alpha 1	Homo sapiens	104-113
27457048-6	1990	These data indicate that IFN-alpha inhibits transferrin receptor biosynthesis in an iron-independent fashion and the subsequent cellular iron-deficiency state may play a role in the antiproliferative action of IFN-alpha.	Iron	84-88	interferon alpha 1	Homo sapiens	25-34
27457048-6	1990	These data indicate that IFN-alpha inhibits transferrin receptor biosynthesis in an iron-independent fashion and the subsequent cellular iron-deficiency state may play a role in the antiproliferative action of IFN-alpha.	Iron	84-88	transferrin	Homo sapiens	44-55
27457048-6	1990	These data indicate that IFN-alpha inhibits transferrin receptor biosynthesis in an iron-independent fashion and the subsequent cellular iron-deficiency state may play a role in the antiproliferative action of IFN-alpha.	Iron	84-88	interferon alpha 1	Homo sapiens	210-219
2127409-2	1990	Iron release was enhanced in the presence of SOD, catalase and under anaerobic conditions.	Iron	0-4	superoxide dismutase 1	Homo sapiens	45-48
2107229-9	1990	Examination of cows lacking lactoferrin suggested that transferrin plays an important role as an iron carrier from a cow to her newborn calf.	Iron	97-101	serotransferrin	Bos taurus	55-66
2385435-0	1990	Iron-binding proteins in the human vitreous: lactoferrin and transferrin in health and in proliferative intraocular disorders.	Iron	0-4	transferrin	Homo sapiens	61-72
2362636-4	1990	A program of weekly phlebotomy combined with recombinant human erythropoietin (rhEPO) therapy was tried to eliminate the iron congestion.	Iron	121-125	erythropoietin	Homo sapiens	63-77
2077417-0	1990	Correction of serious iron overload in a chronic hemodialysis patient by recombinant human erythropoietin and removal of red blood cells: confirmation by follow-up liver biopsy.	Iron	22-26	erythropoietin	Homo sapiens	91-105
2077417-1	1990	A chronic hemodialysis case, a 46-year-old woman with secondary hemosiderosis induced by parenteral iron and blood transfusion due to a refractory anemia, was effectively treated with recombinant human erythropoietin and the removal of red blood cells.	Iron	100-104	erythropoietin	Homo sapiens	202-216
2385435-1	1990	Transferrin, recently detected in preretinal membranes, may contribute to cell proliferation by iron donation for mitosis.	Iron	96-100	transferrin	Homo sapiens	0-11
2294524-2	1990	Raising the saturation of transferrin with oral carbonyl iron had little effect on splenic release of 59Fe but markedly inhibited hepatic release.	Iron	57-61	transferrin	Rattus norvegicus	26-37
2396117-2	1990	The significance of copper compounds (ceruloplasmin) in bone tissue synthesis was revealed; the role of bound iron (transferrin) in the development and maintenance of the inflammatory process induced by opportunistic bacteria and in bone regeneration was confirmed.	Iron	110-114	transferrin	Homo sapiens	116-127
2294524-11	1990	When the saturation of transferrin is raised, a significant proportion of the iron is transported from the spleen to the liver either in small molecular weight complexes or in ferritin.	Iron	78-82	transferrin	Rattus norvegicus	23-34
1366420-1	1990	The iron-binding plasma protein transferrin (TF) is essential for supplying iron to cells and the prevention of iron toxicity.	Iron	4-8	transferrin	Homo sapiens	32-43
1366420-1	1990	The iron-binding plasma protein transferrin (TF) is essential for supplying iron to cells and the prevention of iron toxicity.	Iron	4-8	transferrin	Homo sapiens	45-47
1366420-1	1990	The iron-binding plasma protein transferrin (TF) is essential for supplying iron to cells and the prevention of iron toxicity.	Iron	76-80	transferrin	Homo sapiens	32-43
1366420-1	1990	The iron-binding plasma protein transferrin (TF) is essential for supplying iron to cells and the prevention of iron toxicity.	Iron	76-80	transferrin	Homo sapiens	45-47
1366420-1	1990	The iron-binding plasma protein transferrin (TF) is essential for supplying iron to cells and the prevention of iron toxicity.	Iron	76-80	transferrin	Homo sapiens	32-43
1366420-1	1990	The iron-binding plasma protein transferrin (TF) is essential for supplying iron to cells and the prevention of iron toxicity.	Iron	76-80	transferrin	Homo sapiens	45-47
2075449-0	1990	Transferrin receptors in the regulation of cell growth and iron homeostasis.	Iron	59-63	transferrin	Homo sapiens	0-11
2251817-0	1990	[The effect of iron carrier proteins on the transplantation of H-2 locus-incompatible bone marrow in irradiated mice].	Iron	15-19	histocompatibility-2, MHC	Mus musculus	63-66
2251817-8	1990	Iron carrier proteins seem to provide a novel unexpected means for achieving a successful engraftment of allogeneic bone marrow in immunologically hostile murine H-2 combinations and may open a new approach in the clinical area.	Iron	0-4	histocompatibility-2, MHC	Mus musculus	162-165
33772994-1	2021	We report the synthesis and characterization of the first terminal imido complex of an Fe-S cluster, (IMes)3Fe4S4=NDipp (2; IMes = 1,3-dimesitylimidazol-2-ylidene, Dipp = 2,6-diisopropylphen-yl), which is generated by oxidative group transfer from DippN3 to the all-ferrous cluster (IMes)3Fe4S4(PPh3).	Iron	87-91	nudix hydrolase 3	Homo sapiens	115-119
3942757-0	1986	The study of iron mobilisation from transferrin using alpha-ketohydroxy heteroaromatic chelators.	Iron	13-17	transferrin	Homo sapiens	36-47
3942757-1	1986	A group of heteroaromatic chelators with an alpha-ketohydroxy binding site have been tested for their ability to mobilise iron from transferrin in vitro.	Iron	122-126	transferrin	Homo sapiens	132-143
3942757-2	1986	When these chelators were mixed with iron-saturated transferrin at physiological pH, biphasic reactions were observed.	Iron	37-41	transferrin	Homo sapiens	52-63
2168237-5	1990	The study of iron status showed increased serum ferritin concentration (mean = 421.4 +/- 343.7 ug/dl) and transferrin saturation ratio (53.9% +/- 20.5%).	Iron	13-17	transferrin	Homo sapiens	106-117
33588074-5	2021	Following ICH, IL-10-deficient mice had more severe neuroinflammation, brain edema, iron deposition, and neurologic deficits associated with delayed hematoma clearance.	Iron	84-88	interleukin 10	Mus musculus	15-20
33811904-0	2021	Fractalkine enhances endometrial receptivity and activates iron transport towards trophoblast cells in an in vitro co-culture system of HEC-1A and JEG-3 cells.	Iron	59-63	C-X3-C motif chemokine ligand 1	Homo sapiens	0-11
33811904-6	2021	The NRF2 transcription factor increases the expression of the iron exporter ferroportin in HEC-1A cells activating iron release towards JEG-3 trophoblast cells.	Iron	62-66	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
33811904-6	2021	The NRF2 transcription factor increases the expression of the iron exporter ferroportin in HEC-1A cells activating iron release towards JEG-3 trophoblast cells.	Iron	115-119	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
33811904-7	2021	The iron measurements show that iron content of endometrial cells decreases while heme concentration increases at FKN treatment.	Iron	4-8	C-X3-C motif chemokine ligand 1	Homo sapiens	114-117
33765133-3	2021	Here, we show that the absence of PPARgamma affects neonatal development and VCAM-1 expression of splenic iron-recycling red pulp macrophages (RPMs) and bone marrow erythroblastic island macrophages (EIMs).	Iron	106-110	peroxisome proliferator activated receptor gamma	Homo sapiens	34-43
33765133-3	2021	Here, we show that the absence of PPARgamma affects neonatal development and VCAM-1 expression of splenic iron-recycling red pulp macrophages (RPMs) and bone marrow erythroblastic island macrophages (EIMs).	Iron	106-110	vascular cell adhesion molecule 1	Homo sapiens	77-83
33811904-9	2021	Based on our results it seems that FKN enhances the establishment of endometrial receptivity and meanwhile it regulates the iron homeostasis of endometrium contributing to the iron availability of the trophoblast cells and the embryo.	Iron	124-128	C-X3-C motif chemokine ligand 1	Homo sapiens	35-38
33811904-9	2021	Based on our results it seems that FKN enhances the establishment of endometrial receptivity and meanwhile it regulates the iron homeostasis of endometrium contributing to the iron availability of the trophoblast cells and the embryo.	Iron	176-180	C-X3-C motif chemokine ligand 1	Homo sapiens	35-38
33942503-4	2021	Iron overload would promote the expression of chondrocytes catabolic markers, MMP3 and MMP13 expression.	Iron	0-4	matrix metallopeptidase 3	Homo sapiens	78-82
33942503-4	2021	Iron overload would promote the expression of chondrocytes catabolic markers, MMP3 and MMP13 expression.	Iron	0-4	matrix metallopeptidase 13	Homo sapiens	87-92
33940654-5	2022	Iron scavenging during hemolysis using deferoxamine decreased the ability of the HMVs to enhance thrombin generation.	Iron	0-4	coagulation factor II, thrombin	Homo sapiens	97-105
33940654-6	2022	Furthermore, the addition of ferric chloride (FeCl3) to plasma propagated thrombin generation in a FVIII and FIX-dependent manner suggesting that iron positively affects blood coagulation.	Iron	146-150	coagulation factor II, thrombin	Homo sapiens	74-82
33940654-9	2022	Overall, our results provide evidence for the contribution of iron ions derived from hemolytic RBCs to thrombin generation.	Iron	62-66	coagulation factor II, thrombin	Homo sapiens	103-111
33811979-2	2021	In studies of physiological responses to other erythropoietic stimuli, erythropoietin induced erythroblast secretion of erythroferrone (ERFE), which acts on the liver to suppress hepcidin production and mobilize iron for erythropoiesis.	Iron	212-216	erythropoietin	Homo sapiens	71-85
33821487-8	2021	It summarises the excess-iron-induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K/AKT, MAPK, p53, AMPK/MFF/DRP1 and Wnt.	Iron	25-29	AKT serine/threonine kinase 1	Homo sapiens	133-136
33821487-8	2021	It summarises the excess-iron-induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K/AKT, MAPK, p53, AMPK/MFF/DRP1 and Wnt.	Iron	25-29	tumor protein p53	Homo sapiens	144-147
33815094-12	2021	A significant increase in HO-1 expression of serum and iron deposition in SN was also observed in the PD mouse model, and the SnPP could significantly reduce iron deposition in the SN.	Iron	55-59	heme oxygenase 1	Mus musculus	26-30
33775486-10	2021	Selenium deficiency was less frequent but found in 24% cases, while iron deficiency suggested by low transferrin saturation was found in 23% patients.	Iron	68-72	transferrin	Homo sapiens	101-112
33802993-6	2021	Furthermore, exposure to relatively non-toxic Fe@CeO2 NPs, but not the toxic Cr@CeO2 NPs, resulted in increased binding of MLL1 complex, a major histone lysine methylase mediating trimethylation of histone H3 lysine 4, at the NRF2 promoter.	Iron	46-48	NFE2 like bZIP transcription factor 2	Homo sapiens	226-230
33802088-1	2021	DDX11/ChlR1 is a super-family two iron-sulfur cluster containing DNA helicase with roles in DNA replication and sister chromatid cohesion establishment, and general chromosome architecture.	Iron	34-38	DEAD/H box helicase 11	Mus musculus	0-5
33802088-1	2021	DDX11/ChlR1 is a super-family two iron-sulfur cluster containing DNA helicase with roles in DNA replication and sister chromatid cohesion establishment, and general chromosome architecture.	Iron	34-38	DEAD/H box helicase 11	Mus musculus	6-11
33232715-6	2021	Intracellular iron is exported by ferroportin and bound with transferrin.	Iron	14-18	transferrin	Homo sapiens	61-72
33232715-7	2021	In most types of cell including erythrocyte, transferrin-bound iron is incorporated through transferrin-transferrin receptor system.	Iron	63-67	transferrin	Homo sapiens	45-56
33232715-7	2021	In most types of cell including erythrocyte, transferrin-bound iron is incorporated through transferrin-transferrin receptor system.	Iron	63-67	transferrin	Homo sapiens	92-103
33815364-1	2021	The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.	Iron	196-200	transferrin	Homo sapiens	4-15
33815364-1	2021	The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.	Iron	237-241	transferrin	Homo sapiens	4-15
33802720-6	2021	Results indicate that both types of iron supplementation are equally effective in the treatment of IDA, restoring hemoglobin, hematocrit, erythrocytes, free iron and transferrin levels in 15 days, with no statistical differences between treated groups and control.	Iron	36-40	transferrin	Homo sapiens	166-177
33809705-5	2021	Both HIV and low iron stores were associated with lower height-for-age Z-scores (HAZ, p < 0.001 and p = 0.02, respectively), while both HIV and sufficient iron stores were associated with significantly higher CRP and AGP concentrations.	Iron	155-159	C-reactive protein	Homo sapiens	209-212
33809705-6	2021	HIV+ children with low iron stores had significantly lower HAZ, significantly higher sTfR concentrations, and significantly higher prevalence of subclinical inflammation (CRP 0.05 to 4.99 mg/L) (54%) than both HIV-ve groups.	Iron	23-27	C-reactive protein	Homo sapiens	171-174
33815094-13	2021	Conclusions: The high level of HO-1 may be the common mechanism of iron deposition and low HGB in PD.	Iron	67-71	heme oxygenase 1	Mus musculus	31-35
33815094-14	2021	Therefore, the findings presented in this study indicate that HO-1 correlates with brain iron deposition and anemia in PD.	Iron	89-93	heme oxygenase 1	Mus musculus	62-66
33237050-8	2021	Moreover, an Fe/NC-SA-based assay was successfully validated using human serum samples for ALP determination with satisfactory results, and has broad prospects in the field of biosensing.	Iron	13-15	alkaline phosphatase, placental	Homo sapiens	91-94
33589702-8	2021	Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients.	Iron	53-57	fibrinogen beta chain	Homo sapiens	89-99
33815893-5	2021	Our findings show that WO-catalyzed by mcp-iron complexes proceeds via homogeneous species, whereas the analogous manganese complex forms a heterogeneous deposit on the electrode surface.	Iron	43-47	CD46 molecule	Homo sapiens	39-42
33817543-0	2021	Common Variants in the TMPRSS6 Gene Alter Hepcidin but not Plasma Iron in Response to Oral Iron in Healthy Gambian Adults: A Recall-by-Genotype Study.	Iron	91-95	transmembrane serine protease 6	Homo sapiens	23-30
33817543-3	2021	Objectives: To investigate the effects of risk alleles for low iron status, namely TMPRSS6 rs2235321, rs855791, and rs4820268, on responses to oral iron in healthy Gambian adults.	Iron	63-67	transmembrane serine protease 6	Homo sapiens	83-90
33233553-11	2020	SIRT3KO significantly exacerbated Ang-II-induced iron accumulation.	Iron	49-53	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	34-40
33815703-9	2021	Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P <0.05).	Iron	50-54	solute carrier family 17 member 5	Homo sapiens	6-9
33815703-9	2021	Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P <0.05).	Iron	98-102	solute carrier family 17 member 5	Homo sapiens	6-9
33236955-0	2021	Unconventional endocytosis and trafficking of Transferrin Receptor induced by iron.	Iron	78-82	transferrin	Homo sapiens	46-57
33233561-11	2020	We also discuss chelation strategies that can be used with currently available chelators, balancing the need to keep non-transferrin-bound iron levels to a minimum (zero) 24 h a day, 7 days a week and the risk of over-chelation.	Iron	139-143	transferrin	Homo sapiens	121-132
26319559-2	2016	In response to hypoxia, in the PWM, there was increased expression of proteins involved in iron acquisition, such as iron regulatory proteins (IRP1, IRP2) and transferrin receptor in oligodendrocytes.	Iron	91-95	iron responsive element binding protein 2	Homo sapiens	149-153
33237527-1	2020	Mutations in pank2 gene encoding pantothenate kinase 2 determine a pantothenate kinase-associated neurodegeneration, a rare disorder characterized by iron deposition in the globus pallidus.	Iron	150-154	pantothenate kinase 2	Danio rerio	13-18
33237527-1	2020	Mutations in pank2 gene encoding pantothenate kinase 2 determine a pantothenate kinase-associated neurodegeneration, a rare disorder characterized by iron deposition in the globus pallidus.	Iron	150-154	pantothenate kinase 2	Danio rerio	33-54
32795936-9	2020	Alterations of the IRP1/Bcl-xL axis navigate iron stresses induced mitophagy.	Iron	45-49	BCL2 like 1	Homo sapiens	24-30
26319559-2	2016	In response to hypoxia, in the PWM, there was increased expression of proteins involved in iron acquisition, such as iron regulatory proteins (IRP1, IRP2) and transferrin receptor in oligodendrocytes.	Iron	91-95	transferrin	Homo sapiens	159-170
29136618-7	2017	Underexpression of hepcidin results in body iron overload, which triggers the production of reactive oxygen species simultaneously thought to play a major role in diabetes pathogenesis mediated both by beta-cell failure and insulin resistance.	Iron	44-48	insulin	Homo sapiens	224-231
27455459-6	2016	Our results reveal an unexpected arrangement of Elp3 lysine acetyltransferase (KAT) and radical S-adenosyl methionine (SAM) domains, which share a large interface and form a composite active site and tRNA-binding pocket, with an iron-sulfur cluster located in the dimerization interface of two DmcElp3 molecules.	Iron	229-233	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	48-52
26319559-2	2016	In response to hypoxia, in the PWM, there was increased expression of proteins involved in iron acquisition, such as iron regulatory proteins (IRP1, IRP2) and transferrin receptor in oligodendrocytes.	Iron	117-121	iron responsive element binding protein 2	Homo sapiens	149-153
26319559-4	2016	The increased concentration of iron within hypoxic oligodendrocytes was found to elicit ryanodine receptor (RyR) expression, and the expression of endoplasmic reticulum (ER) stress markers such as binding-immunoglobulin protein (BiP) and inositol-requiring enzyme (IRE)-1alpha.	Iron	31-35	ryanodine receptor 1	Homo sapiens	88-106
26319559-4	2016	The increased concentration of iron within hypoxic oligodendrocytes was found to elicit ryanodine receptor (RyR) expression, and the expression of endoplasmic reticulum (ER) stress markers such as binding-immunoglobulin protein (BiP) and inositol-requiring enzyme (IRE)-1alpha.	Iron	31-35	ryanodine receptor 1	Homo sapiens	108-111
26267258-1	2015	In this study, the synthesis and characterization of sepiolite-supported nanoscale zero-valent iron particles (S-NZVI) was investigated for the adsorption/reduction of Cr(VI) and Pb(II) ions.	Iron	95-99	submaxillary gland androgen regulated protein 3B	Homo sapiens	168-185
26267258-2	2015	Nanoscale zero-valent iron (NZVI) supported on sepiolite was successfully used to remove Cr(VI) and Pb(II) from groundwater with high efficiency.	Iron	22-26	submaxillary gland androgen regulated protein 3B	Homo sapiens	100-106
26053282-12	2015	It should also be considered in future work in the field that because iron is a cofactor for EGLN1, there may be significant associations of phenotypes with the significant degrees of variation seen in tissue iron among human populations.	Iron	70-74	egl-9 family hypoxia inducible factor 1	Homo sapiens	93-98
26319559-4	2016	The increased concentration of iron within hypoxic oligodendrocytes was found to elicit ryanodine receptor (RyR) expression, and the expression of endoplasmic reticulum (ER) stress markers such as binding-immunoglobulin protein (BiP) and inositol-requiring enzyme (IRE)-1alpha.	Iron	31-35	heat shock protein family A (Hsp70) member 5	Homo sapiens	229-232
26053282-12	2015	It should also be considered in future work in the field that because iron is a cofactor for EGLN1, there may be significant associations of phenotypes with the significant degrees of variation seen in tissue iron among human populations.	Iron	209-213	egl-9 family hypoxia inducible factor 1	Homo sapiens	93-98
26560363-0	2015	Regulation of iron homeostasis by the p53-ISCU pathway.	Iron	14-18	tumor protein p53	Homo sapiens	38-41
26560363-0	2015	Regulation of iron homeostasis by the p53-ISCU pathway.	Iron	14-18	iron-sulfur cluster assembly enzyme	Homo sapiens	42-46
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	35-39	tumor protein p53	Homo sapiens	21-24
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	35-39	iron-sulfur cluster assembly enzyme	Homo sapiens	93-97
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	99-103	tumor protein p53	Homo sapiens	21-24
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	99-103	iron-sulfur cluster assembly enzyme	Homo sapiens	93-97
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	200-202	tumor protein p53	Homo sapiens	21-24
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	200-202	iron-sulfur cluster assembly enzyme	Homo sapiens	93-97
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	42-46	iron-sulfur cluster assembly enzyme	Homo sapiens	13-17
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	108-112	iron-sulfur cluster assembly enzyme	Homo sapiens	13-17
26560363-5	2015	In addition, in response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells.	Iron	110-114	tumor protein p53	Homo sapiens	40-43
26560363-6	2015	HCT116 p53(+/+) cells were resistant to iron accumulation, but HCT116 p53(-/-) cells accumulated intracellular iron after DNA damage.	Iron	111-115	tumor protein p53	Homo sapiens	70-73
26216855-2	2015	That pathological scenario contrasts with the physiological one, which is characterized by an efficient maintenance of all plasma iron bound to circulating transferrin, due to a tight control of iron ingress into plasma by the hormone hepcidin.	Iron	195-199	transferrin	Homo sapiens	156-167
26560363-9	2015	Our finding revealed a novel role of the p53-ISCU pathway in the maintenance of iron homeostasis in hepatocellular carcinogenesis.	Iron	80-84	tumor protein p53	Homo sapiens	41-44
26216855-3	2015	Within cells, most of the acquired iron becomes protein-associated, as once released from endocytosed transferrin, it is used within mitochondria for the synthesis of protein prosthetic groups or it is incorporated into enzyme active centers or alternatively sequestered within ferritin shells.	Iron	35-39	transferrin	Homo sapiens	102-113
26216855-6	2015	In thalassemia and other transfusion iron-loading conditions, once transferrin saturation exceeds about 70%, labile forms of iron enter the circulation and can gain access to various types of cells via resident transporters or channels.	Iron	37-41	transferrin	Homo sapiens	67-78
26560363-9	2015	Our finding revealed a novel role of the p53-ISCU pathway in the maintenance of iron homeostasis in hepatocellular carcinogenesis.	Iron	80-84	iron-sulfur cluster assembly enzyme	Homo sapiens	45-49
26216855-6	2015	In thalassemia and other transfusion iron-loading conditions, once transferrin saturation exceeds about 70%, labile forms of iron enter the circulation and can gain access to various types of cells via resident transporters or channels.	Iron	125-129	transferrin	Homo sapiens	67-78
15626737-7	2005	Conversely, iron inhibited IFN-gamma-induced apoptosis in malignant T cells in serum-free conditions.	Iron	12-16	interferon gamma	Homo sapiens	27-36
24120603-6	2014	All of them were splenectomised, had a higher nucleated red blood cell count and higher levels of the soluble form of transferrin receptor with respect to patients without extramedullary haematopoiesis; furthermore, patients with EMH had a lower transfusional iron intake and a higher pre-transfusion haemoglobin level as compared with those without extramedullary haematopoiesis.	Iron	260-264	transferrin	Homo sapiens	118-129
15626737-0	2005	Iron regulates T-lymphocyte sensitivity to the IFN-gamma/STAT1 signaling pathway in vitro and in vivo.	Iron	0-4	interferon gamma	Homo sapiens	47-56
15626737-3	2005	Here we show that iron uptake mediated by the transferrin receptor (TfR) delivers a signal that leads to IFN-gammaR2 internalization and thus plays an essential role in attenuating activation of the IFN-gamma/STAT1 pathway in human T lymphocytes.	Iron	18-22	interferon gamma	Homo sapiens	105-114
26358513-1	2015	BMP-SMAD signalling plays a crucial role in numerous biological processes including embryonic development and iron homeostasis.	Iron	110-114	SMAD family member 7	Homo sapiens	4-8
26358513-3	2015	We hypothesised that molecules which mediate BMP-SMAD signalling play important roles in the regulation of iron homeostasis and variants in these proteins may be potential genetic modifiers of iron-related diseases.	Iron	107-111	SMAD family member 7	Homo sapiens	49-53
26358513-3	2015	We hypothesised that molecules which mediate BMP-SMAD signalling play important roles in the regulation of iron homeostasis and variants in these proteins may be potential genetic modifiers of iron-related diseases.	Iron	193-197	SMAD family member 7	Homo sapiens	49-53
26358513-7	2015	In conclusion, we have identified a hitherto unrecognised link, endofin, between the BMP-SMAD signalling pathway, and the regulation of hepcidin expression and iron homeostasis.	Iron	160-164	SMAD family member 7	Homo sapiens	89-93
22689674-12	2012	Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4-mediated inflammatory responses in macrophages.	Iron	34-38	toll-like receptor 4	Mus musculus	87-91
17477085-11	2007	Saturation of transferrin lower than 15%, which indicated deficiency of iron for erythropoiesis, was observed in 26%, 13% and 19% patients of group I, II and III respectively.	Iron	72-76	transferrin	Homo sapiens	14-25
15626737-9	2005	These data provide valuable insights for novel therapeutic approaches aimed at reinstating the IFN-gamma/STAT1 apoptotic signaling pathway in autoreactive or neoplastic T cells by means of iron chelation.	Iron	189-193	interferon gamma	Homo sapiens	95-104
18629168-1	2004	A number of bacterial species, mostly proteobacteria, possess monothiol glutaredoxins homologous to the Saccharomyces cerevisiae mitochondrial protein Grx5, which is involved in iron-sulphur cluster synthesis.	Iron	178-182	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	151-155
9507017-6	1998	To determine whether Fes-induced STAT3 activation is dependent upon endogenous mammalian kinases, co-expression studies were also performed in Sf-9 insect cells.	Iron	21-24	signal transducer and activator of transcription 3	Homo sapiens	33-38
9507017-7	1998	Fes also induced a dramatic increase in STAT3 DNA binding activity in this system, whereas no activation of STAT5 was observed.	Iron	0-3	signal transducer and activator of transcription 3	Homo sapiens	40-45
9507017-9	1998	Fes induced strong tyrosine phosphorylation of STAT3 in both expression systems, consistent with the gel-shift results.	Iron	0-3	signal transducer and activator of transcription 3	Homo sapiens	47-52
8535154-1	1995	Human serum transferrin, the major iron transport protein in humans, is a monomeric glycoprotein that is composed of two homologous domains; the N-terminal domain is formed by amino acids 1-331 and the C-terminal domain is formed by amino acids 338-679.	Iron	35-39	transferrin	Homo sapiens	12-23
8535154-7	1995	This study demonstrates that N-terminal half-transferrin can easily be expressed in the simple host system, Pichia pastoris, and that the purified protein is capable of reversibly binding iron.	Iron	188-192	transferrin	Homo sapiens	45-56
34883381-8	2022	This work illustrates Fe(VI) could remove BP-1 in water environments efficiently, and the newly proposed dioxygen transfer mechanism herein may contribute to the development of Fe(VI) chemistry.	Iron	22-24	BP1	Homo sapiens	42-46
8592704-1	1995	In order to investigate the secondary, tertiary, and dynamic structure of the iron-free (apo) and iron-saturated (holo) forms of human serum transferrin and its amino (N)-terminal lobe at the physiologically relevant pHs 7.4 and 5.0, we have combined ultraviolet circular dichroism (CD) spectroscopy with transient-electric birefringence (TEB) measurements.	Iron	78-82	transferrin	Homo sapiens	141-152
8592704-4	1995	In contrast, TEB results indicate dramatic changes in the dynamic structure of transferrin both upon binding of iron and decrease of pH.	Iron	112-116	transferrin	Homo sapiens	79-90
8650058-1	1995	The aim of the study was to present the relation between serum parameters connected with iron metabolism; serum iron, transferrin and ferritin.	Iron	89-93	transferrin	Homo sapiens	118-129
8650058-5	1995	It can be concluded that ferritin and transferrin may be considered as independent diagnostic in differential diagnosis of real (latent) and false iron depletion.	Iron	147-151	transferrin	Homo sapiens	38-49
34883381-8	2022	This work illustrates Fe(VI) could remove BP-1 in water environments efficiently, and the newly proposed dioxygen transfer mechanism herein may contribute to the development of Fe(VI) chemistry.	Iron	177-179	BP1	Homo sapiens	42-46
34896509-1	2022	Injection of zero-valent iron nanoparticles (nZVI) into aquifers has gained increasing attention of researchers for in-situ treatment of NO3--contaminated groundwater.	Iron	25-29	NBL1, DAN family BMP antagonist	Homo sapiens	137-140
34954215-2	2022	The peroxidase active form of Cytc occurs due to local conformational changes that support the opening of the heme crevice and the loss of an axial ligand between Met80 and heme Fe.	Iron	178-180	cytochrome c, somatic	Homo sapiens	30-34
34693556-7	2022	Therefore, this study revealed the comparative dietary enhancing effect of FE- and FA-formulated biscuit on sexual behaviour activity, hormonal levels and the level of eNOS and TNF-alpha genes expressed in hypertensive rats.	Iron	75-77	tumor necrosis factor	Rattus norvegicus	177-186
34741938-5	2022	For the continuous tests, column filled with chitosan-zero valent iron-based composites, exhibited optimal removal efficiency and achieved average removal values of 98.84%, 88.28%, 95.65% and 87.10% for Cu(II), Co(II), Cr(VI) and As(III) during the whole 30-day operation, respectively.	Iron	66-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
34474358-7	2022	FT-IR and XPS analyses showed that the main mechanism for the removal of phosphate and As(V) from water by 1Ce-MIL-101-NH2 was the formation of an Fe/CeOP inner complex through ligand complexation and electrostatic attraction.	Iron	147-149	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	87-92
34897777-1	2022	INTRODUCTION: For the maintenance treatment of patients with hereditary hemochromatosis (HH), it is advised to keep the transferrin saturation (TSAT) <70% to prevent formation of non-transferrin-bound iron and labile plasma iron.	Iron	201-205	transferrin	Homo sapiens	183-194
34699876-2	2022	This study used 2,4,6-trichlorophenol (2,4,6-TCP) as the target pollutant, and employed ultrasound (US) enhanced zero-valent iron (Fe0)/EDTA/air system (FEA), namely US/FEA, to remove 2,4,6-TCP.	Iron	125-129	serine peptidase inhibitor Kazal type 1	Homo sapiens	190-193
34699876-9	2022	The ROS of US/FEA included  OH, O2 - and Fe(IV), where Fe(IV) was the main contributor to the removal of 2,4,6-TCP.	Iron	55-57	serine peptidase inhibitor Kazal type 1	Homo sapiens	111-114
34699878-9	2022	Thus, the in-situ formed biogenic FeS secondary minerals were demonstrated to mediate and accelerate interfacial electron transfer from S. oneidensis MR-1 cells to ferrihydrite through interfacing with the bacterial EET routes, especially Mtr pathway.	Iron	34-37	tryptophan permease	Shewanella oneidensis MR-1	239-242
34906694-3	2022	In this review, we discuss key biometals such as zinc, copper, and iron that interact with protein species involved in AD, mainly Abeta, tau, and the late-onset AD risk factor Apolipoprotein E (APOE).	Iron	67-71	apolipoprotein E	Homo sapiens	176-192
34906694-3	2022	In this review, we discuss key biometals such as zinc, copper, and iron that interact with protein species involved in AD, mainly Abeta, tau, and the late-onset AD risk factor Apolipoprotein E (APOE).	Iron	67-71	apolipoprotein E	Homo sapiens	194-198
34837396-8	2022	Using these cells, we demonstrated that the non-TF (transferrin)-bound iron pathway dominantly mediated the accumulation of iron.	Iron	124-128	transferrin	Homo sapiens	52-63
34626672-10	2022	Uhep/UCr values vary over time and are affected by treatment with Epo, suggesting that EP neonates can regulate hepcidin and therefore their iron status.	Iron	141-145	erythropoietin	Homo sapiens	66-69
34837396-9	2022	Moreover, the loss of WDR45 led to defects in ferritinophagy, a form of autophagy that degrades the iron storage protein ferritin.	Iron	100-104	WD repeat domain 45	Homo sapiens	22-27
34837396-0	2022	A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.	Iron	66-70	WD repeat domain 45	Homo sapiens	26-31
34837396-6	2022	However, how WDR45 deficiency leads to brain iron overload remains unclear.	Iron	45-49	WD repeat domain 45	Homo sapiens	13-18
34837396-10	2022	We showed that impaired ferritinophagy contributes to iron accumulation in WDR45-KO cells.	Iron	54-58	WD repeat domain 45	Homo sapiens	75-80
34837396-8	2022	Using these cells, we demonstrated that the non-TF (transferrin)-bound iron pathway dominantly mediated the accumulation of iron.	Iron	71-75	transferrin	Homo sapiens	52-63
34837396-12	2022	Thus, our study links WDR45 to specific iron acquisition pathways and ferritinophagy.	Iron	40-44	WD repeat domain 45	Homo sapiens	22-27
34823116-4	2022	In the mitochondria, Fe-S cluster assembly is accomplished through the coordinated activity of the ISC pathway protein complex composed of a cysteine desulfurase, a scaffold protein, the accessory ISD11 protein, the acyl carrier protein, frataxin, and a ferredoxin; downstream events that accomplish Fe-S cluster transfer and delivery are driven by additional chaperone/delivery proteins that interact with the ISC assembly complex.	Iron	21-25	LYR motif containing 4	Homo sapiens	197-202
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	58-62	NFE2 like bZIP transcription factor 2	Homo sapiens	193-244
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	58-62	NFE2 like bZIP transcription factor 2	Homo sapiens	246-250
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	141-145	NFE2 like bZIP transcription factor 2	Homo sapiens	193-244
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	141-145	NFE2 like bZIP transcription factor 2	Homo sapiens	246-250
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	176-180	NFE2 like bZIP transcription factor 2	Homo sapiens	193-244
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	176-180	NFE2 like bZIP transcription factor 2	Homo sapiens	246-250
34813762-4	2022	PALP captured by BODIPY-C11 can be suppressed by lipophilic antioxidants and iron chelation, and is dependent on PUFA-lipid levels.	Iron	77-81	alkaline phosphatase, placental	Homo sapiens	0-4
34742966-12	2022	By contrast, FWFe(3) samples showed a decreased adsorption capacity for Pb(II) with increased concentration of embedded iron.	Iron	120-124	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
34965724-0	2022	PPAR-alpha Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer"s Diseases.	Iron	64-68	peroxisome proliferator activated receptor alpha	Mus musculus	0-10
34965724-7	2022	In an in vitro study of APPsw cells, we found that PPAR-alpha directly bound with GPx4 intron3 to promote GPx4 transcription and reduced the iron transport capability.	Iron	141-145	peroxisome proliferator activated receptor alpha	Mus musculus	51-61
34965724-8	2022	Our data suggested that activation of PPAR-alpha by GW7647 improved the disruption of iron homeostasis in the brain of APP/PS1 mice and alleviated neuronal inflammation and lipid peroxidation, which was possibly related to the upregulated transcription of GPx4 mediated by the interaction of GPx4 noncoding region and the PPAR-alpha.	Iron	86-90	peroxisome proliferator activated receptor alpha	Mus musculus	38-48
34965724-8	2022	Our data suggested that activation of PPAR-alpha by GW7647 improved the disruption of iron homeostasis in the brain of APP/PS1 mice and alleviated neuronal inflammation and lipid peroxidation, which was possibly related to the upregulated transcription of GPx4 mediated by the interaction of GPx4 noncoding region and the PPAR-alpha.	Iron	86-90	peroxisome proliferator activated receptor alpha	Mus musculus	322-332
34961311-8	2022	Scavenging and probing experiments for identifying oxidative species indicated that high-valent iron species (Fe(V)/Fe(IV)) were responsible for the enhanced degradation.	Iron	96-100	FEV transcription factor, ETS family member	Homo sapiens	110-115
34961311-8	2022	Scavenging and probing experiments for identifying oxidative species indicated that high-valent iron species (Fe(V)/Fe(IV)) were responsible for the enhanced degradation.	Iron	116-118	FEV transcription factor, ETS family member	Homo sapiens	110-115
34861512-4	2022	The in-situ gelatinized hydrogel, with outstanding photothermal effect and chemodynamic effect derived from the doped Fe in BGN-Fe-Ag2S, can not only eliminate multidrug-resistant bacteria but also efficiently ablated tumor during treatment.	Iron	118-120	biglycan	Homo sapiens	124-127
34637551-0	2022	PLASMA NON TRANSFERRIN BOUND IRON- NTBI REVISITED Implications for systemic iron overload and in iv iron supplementation.	Iron	76-80	transferrin	Homo sapiens	11-22
34637551-1	2022	Non-transferrin bound iron (NTBI) has been classically used to denote a potentially toxic component of plasma detected in systemic iron overload and implicated in end-organ iron accumulation and biological damage.	Iron	22-26	transferrin	Homo sapiens	4-15
34637551-1	2022	Non-transferrin bound iron (NTBI) has been classically used to denote a potentially toxic component of plasma detected in systemic iron overload and implicated in end-organ iron accumulation and biological damage.	Iron	131-135	transferrin	Homo sapiens	4-15
34637551-1	2022	Non-transferrin bound iron (NTBI) has been classically used to denote a potentially toxic component of plasma detected in systemic iron overload and implicated in end-organ iron accumulation and biological damage.	Iron	173-177	transferrin	Homo sapiens	4-15
34826546-0	2022	Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis.	Iron	0-4	poly(ADP-ribose) polymerase 1	Homo sapiens	69-74
34826546-11	2022	Our data further showed that PARP1 expression decreased in endometriotic lesions, which may partially result from iron overload.	Iron	114-118	poly(ADP-ribose) polymerase 1	Homo sapiens	29-34
34826546-12	2022	We also found that PARP1 inhibition aggravated iron overload-induced cell growth suppression, and was implicated in iron overload-induced autophagy.	Iron	47-51	poly(ADP-ribose) polymerase 1	Homo sapiens	19-24
34826546-12	2022	We also found that PARP1 inhibition aggravated iron overload-induced cell growth suppression, and was implicated in iron overload-induced autophagy.	Iron	116-120	poly(ADP-ribose) polymerase 1	Homo sapiens	19-24
34826546-13	2022	In addition, SIRT1 silencing alleviated iron overload-induced PARP1 downregulation and autophagy activation.	Iron	40-44	poly(ADP-ribose) polymerase 1	Homo sapiens	62-67
34826546-14	2022	Overall, our data suggest that iron overload in endometrial stromal cells of endometriotic or adenomyotic lesions may be involved in the inhibition of cell proliferation, simultaneously with the activation of protective autophagy via PARP1/SIRT1 signaling.	Iron	31-35	poly(ADP-ribose) polymerase 1	Homo sapiens	234-239
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	Iron	141-143	biglycan	Homo sapiens	181-184
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	Iron	185-187	biglycan	Homo sapiens	181-184
34861512-4	2022	The in-situ gelatinized hydrogel, with outstanding photothermal effect and chemodynamic effect derived from the doped Fe in BGN-Fe-Ag2S, can not only eliminate multidrug-resistant bacteria but also efficiently ablated tumor during treatment.	Iron	128-130	biglycan	Homo sapiens	124-127
34586549-2	2022	METHODS: Preoperative transferrin levels, calculated by summing serum iron and unsaturated iron-binding capacity, were evaluated in 224 patients who underwent esophagectomy for stage I-III esophageal cancer without preoperative treatment.	Iron	70-74	transferrin	Homo sapiens	22-33
34523465-0	2022	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.	Iron	82-85	submaxillary gland androgen regulated protein 3B	Homo sapiens	9-15
34523465-2	2022	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.	Iron	5-8	submaxillary gland androgen regulated protein 3B	Homo sapiens	48-54
34586549-2	2022	METHODS: Preoperative transferrin levels, calculated by summing serum iron and unsaturated iron-binding capacity, were evaluated in 224 patients who underwent esophagectomy for stage I-III esophageal cancer without preoperative treatment.	Iron	91-95	transferrin	Homo sapiens	22-33
34586549-3	2022	Transferrin levels are directly proportional to total iron-binding capacity (TIBC), and we defined TIBC < 250 mug/dL as low transferrin.	Iron	54-58	transferrin	Homo sapiens	0-11
34950962-7	2021	Additionally, the treatment of both diabetic neuropathy and RLS has evolved to focus first on controlling the blood glucose, avoiding exacerbating medications, supplementing with iron if serum ferritin is low, and starting pharmacotherapy with alpha-2-delta ligands such as gabapentin or pregabalin.	Iron	179-183	RLS1	Homo sapiens	60-63
34962017-2	2022	Therefore, manipulating iron metabolisms, such as using iron chelators, transferrin receptor 1 (TFR1) antibodies, and cytotoxic ligands conjugated to transferrin, has become a considera.	Iron	24-28	transferrin	Homo sapiens	150-161
34987706-12	2021	Therefore, the study revealed that hepcidin could regulate iron metabolism and contribute to ferroptosis via DMT1 signaling activation in rats with EBI after SAH.	Iron	59-63	hepcidin antimicrobial peptide	Rattus norvegicus	35-43
34987706-0	2021	Hepcidin Promoted Ferroptosis through Iron Metabolism which Is Associated with DMT1 Signaling Activation in Early Brain Injury following Subarachnoid Hemorrhage.	Iron	38-42	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
34987706-1	2021	Iron metabolism disturbances play an important role in early brain injury (EBI) after subarachnoid hemorrhage (SAH), and hepcidin largely influences iron metabolism.	Iron	0-4	hepcidin antimicrobial peptide	Rattus norvegicus	121-129
34987706-1	2021	Iron metabolism disturbances play an important role in early brain injury (EBI) after subarachnoid hemorrhage (SAH), and hepcidin largely influences iron metabolism.	Iron	149-153	hepcidin antimicrobial peptide	Rattus norvegicus	121-129
34976431-1	2021	A family of iron-doped manganese-related hollandites, K x Mn1-y Fe y O2-delta (0 <= y <= 0.15), with high performance in CO oxidation have been prepared.	Iron	12-16	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	58-61
34987706-3	2021	We investigated hepcidin on iron metabolism and ferroptosis involving divalent metal transporter 1 (DMT1), and ferroportin-1 (FPN1) in a rat model of SAH.	Iron	28-32	hepcidin antimicrobial peptide	Rattus norvegicus	16-24
34974896-8	2021	Hepcidin, erythroferrone and erythropoietin are regulatory hormones that are integral to iron homeostasis.	Iron	89-93	erythropoietin	Homo sapiens	29-43
34954079-0	2022	IRON-MEDIATED EPIGENETIC ACTIVATION OF NRF2 TARGETS.	Iron	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
34954079-7	2022	Additionally, the induction of TET1 expression was found post-iron treatment, highlighting the possibility of an oxidative-stress induction of TET1 and subsequent hypomethylation of NRF2 targets.	Iron	62-66	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
34954079-10	2022	Furthermore, significant correlations were found between NQO1 and GPX2 demethylation and human intestinal tissue iron-status, thus suggesting that these iron-mediated epigenetic modifications are likely in iron-replete enterocytes.	Iron	113-117	NAD(P)H quinone dehydrogenase 1	Homo sapiens	57-61
34954079-10	2022	Furthermore, significant correlations were found between NQO1 and GPX2 demethylation and human intestinal tissue iron-status, thus suggesting that these iron-mediated epigenetic modifications are likely in iron-replete enterocytes.	Iron	153-157	NAD(P)H quinone dehydrogenase 1	Homo sapiens	57-61
34954079-10	2022	Furthermore, significant correlations were found between NQO1 and GPX2 demethylation and human intestinal tissue iron-status, thus suggesting that these iron-mediated epigenetic modifications are likely in iron-replete enterocytes.	Iron	206-210	NAD(P)H quinone dehydrogenase 1	Homo sapiens	57-61
34874036-2	2021	This feature article highlights the recent advances, from 2015 to August 2021, on sp2 and sp3 C-H bond functionalization reactions of various N-heteroarenes catalyzed by non-precious transition metals (Mn, Co, Fe, Ni, etc.).	Iron	210-212	Sp2 transcription factor	Homo sapiens	82-85
34874036-2	2021	This feature article highlights the recent advances, from 2015 to August 2021, on sp2 and sp3 C-H bond functionalization reactions of various N-heteroarenes catalyzed by non-precious transition metals (Mn, Co, Fe, Ni, etc.).	Iron	210-212	Sp3 transcription factor	Homo sapiens	90-93
34791391-1	2021	Fe(II) exported from cells is oxidized to Fe(III), possibly by a multi-copper ferroxidase (MCF) such as ceruloplasmin (CP), to efficiently bind with the plasma iron transport protein transferrin (TF).	Iron	160-164	transferrin	Homo sapiens	183-194
34791391-1	2021	Fe(II) exported from cells is oxidized to Fe(III), possibly by a multi-copper ferroxidase (MCF) such as ceruloplasmin (CP), to efficiently bind with the plasma iron transport protein transferrin (TF).	Iron	160-164	transferrin	Homo sapiens	196-198
34791391-5	2021	Using spectrophotometric, isothermal titration calorimetric, and surface plasmon resonance methods, we found that Zn(II)-bound CP bound to iron-free TF (apo-TF) with a Kd of 4.2 muM and a stoichiometry CP:TF of ~2:1.	Iron	139-143	transferrin	Homo sapiens	149-151
34791391-5	2021	Using spectrophotometric, isothermal titration calorimetric, and surface plasmon resonance methods, we found that Zn(II)-bound CP bound to iron-free TF (apo-TF) with a Kd of 4.2 muM and a stoichiometry CP:TF of ~2:1.	Iron	139-143	transferrin	Homo sapiens	157-159
34791391-9	2021	In human blood plasma, zinc deficiency reduced the production of Fe(III)2TF and concomitantly increased the production of non-TF-bound iron.	Iron	135-139	transferrin	Homo sapiens	126-128
34791391-10	2021	Our findings suggest that zinc may be involved in the transfer of iron between CP and TF.	Iron	66-70	transferrin	Homo sapiens	86-88
34928961-1	2021	Following the Egyptian withdrawal in the mid-12th century BCE from their involvement in the Arabah copper production, and after an additional period of organization, the degree of copper efficiency and production at Timna and Faynan increased in the Early Iron Age (11th-9th centuries), rendering the region the largest and most advanced smelting centre in the Levant.	Iron	256-260	renin binding protein	Homo sapiens	261-264
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	105-109	nuclear factor kappa B subunit 1	Homo sapiens	40-49
34903297-4	2021	Compared to isogenic CFTR corrected cells (C38), the IB3-1 cells showed increased susceptibility to cell death upon exposure to iron in the form of ferric ammonium citrate (FAC) and the ferroptosis inducer, erastin.	Iron	128-132	CF transmembrane conductance regulator	Homo sapiens	21-25
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	153-157	nuclear factor kappa B subunit 1	Homo sapiens	40-49
34921493-11	2022	We suggest that MhR2R3-MYB4 plays an important part in Fe deficiency stress, which may contribute to improve Fe deficiency tolerance of apple in future.	Iron	55-57	transcription factor MYB51-like	Malus domestica	23-27
34960080-4	2021	In the present study, using a well-established rat model of fetal-neonatal ID, we demonstrated that ID downregulated hippocampal expression of the gene encoding JmjC-ARID domain-containing protein 1B (JARID1B), an iron-dependent histone H3K4 demethylase, associated with a higher histone deacetylase 1 (HDAC1) enrichment and a lower enrichment of acetylated histone H3K9 (H3K9ac) and phosphorylated cAMP response element-binding protein (pCREB).	Iron	214-218	lysine demethylase 5B	Rattus norvegicus	161-199
34960080-4	2021	In the present study, using a well-established rat model of fetal-neonatal ID, we demonstrated that ID downregulated hippocampal expression of the gene encoding JmjC-ARID domain-containing protein 1B (JARID1B), an iron-dependent histone H3K4 demethylase, associated with a higher histone deacetylase 1 (HDAC1) enrichment and a lower enrichment of acetylated histone H3K9 (H3K9ac) and phosphorylated cAMP response element-binding protein (pCREB).	Iron	214-218	lysine demethylase 5B	Rattus norvegicus	201-208
34960080-7	2021	Collectively, these findings demonstrated that the iron-dependent epigenetic mechanism mediated by JARID1B accounted for long-term Bdnf dysregulation by early-life ID.	Iron	51-55	lysine demethylase 5B	Rattus norvegicus	99-106
34870866-13	2021	FXR negatively regulated iron-regulatory proteins IRP1/2 and prevented hepatic iron accumulation.	Iron	25-29	nuclear receptor subfamily 1, group H, member 4	Mus musculus	0-3
34977044-4	2021	NRF2-Keap1 pathway decreases ferroptosis associated with AS by maintaining cellular iron homeostasis, increasing the production glutathione, GPX4 and NADPH.	Iron	84-88	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34977044-4	2021	NRF2-Keap1 pathway decreases ferroptosis associated with AS by maintaining cellular iron homeostasis, increasing the production glutathione, GPX4 and NADPH.	Iron	84-88	kelch like ECH associated protein 1	Homo sapiens	5-10
34879443-1	2022	AIM: To investigate the association between increased serum markers of iron (ferritin and transferrin saturation) and the severity and extent of periodontitis in postmenopausal women.	Iron	71-75	transferrin	Homo sapiens	90-101
34870866-0	2021	Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.	Iron	35-39	nuclear receptor subfamily 1, group H, member 4	Mus musculus	11-31
34870866-0	2021	Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.	Iron	80-84	nuclear receptor subfamily 1, group H, member 4	Mus musculus	11-31
34948188-1	2021	Human serum transferrin (Tf) is a bilobed glycoprotein whose function is to transport iron through receptor-mediated endocytosis.	Iron	86-90	transferrin	Homo sapiens	12-23
34948188-1	2021	Human serum transferrin (Tf) is a bilobed glycoprotein whose function is to transport iron through receptor-mediated endocytosis.	Iron	86-90	transferrin	Homo sapiens	25-27
34948188-3	2021	In this contribution, two powerful X-ray techniques, namely Macromolecular X-ray Crystallography (MX) and Small Angle X-ray Scattering (SAXS), were used to study the conformational changes of iron-free (apo) and iron-loaded (holo) transferrin in crystal and solution states, respectively, at three different pH values of physiological relevance.	Iron	192-196	transferrin	Homo sapiens	231-242
34948188-3	2021	In this contribution, two powerful X-ray techniques, namely Macromolecular X-ray Crystallography (MX) and Small Angle X-ray Scattering (SAXS), were used to study the conformational changes of iron-free (apo) and iron-loaded (holo) transferrin in crystal and solution states, respectively, at three different pH values of physiological relevance.	Iron	212-216	transferrin	Homo sapiens	231-242
34960751-10	2021	Iron levels negatively correlated with IL-6 and higher levels of this cytokine were associated with a worse prognosis.	Iron	0-4	interleukin 6	Homo sapiens	39-43
34946518-4	2021	Hepcidin expression was downregulated in the liver, with increased serum levels of ferritin and iron.	Iron	96-100	hepcidin antimicrobial peptide	Rattus norvegicus	0-8
34946518-7	2021	In conclusion; this study reports anti-oxidant, anti-inflammatory and iron homeostasis regulatory effects of the toll-like receptor 4 (TLR4) antagonist LPS-RS against ethanol induced toxicity in both the liver and the kidney of experimental rats.	Iron	70-74	toll-like receptor 4	Rattus norvegicus	113-133
34946518-7	2021	In conclusion; this study reports anti-oxidant, anti-inflammatory and iron homeostasis regulatory effects of the toll-like receptor 4 (TLR4) antagonist LPS-RS against ethanol induced toxicity in both the liver and the kidney of experimental rats.	Iron	70-74	toll-like receptor 4	Rattus norvegicus	135-139
34870866-4	2021	We aimed to determine whether FXR plays a role in regulating iron hepatotoxicity.	Iron	61-65	nuclear receptor subfamily 1, group H, member 4	Mus musculus	30-33
34870866-13	2021	FXR negatively regulated iron-regulatory proteins IRP1/2 and prevented hepatic iron accumulation.	Iron	79-83	nuclear receptor subfamily 1, group H, member 4	Mus musculus	0-3
34870866-14	2021	Forced FXR expression and ligand activation significantly suppressed iron hepatotoxicity in iron-fed mice.	Iron	69-73	nuclear receptor subfamily 1, group H, member 4	Mus musculus	7-10
34870866-14	2021	Forced FXR expression and ligand activation significantly suppressed iron hepatotoxicity in iron-fed mice.	Iron	92-96	nuclear receptor subfamily 1, group H, member 4	Mus musculus	7-10
34870866-17	2021	CONCLUSIONS: FXR plays a pivotal role in regulating iron homeostasis, and protects mice against iron hepatotoxicity.	Iron	52-56	nuclear receptor subfamily 1, group H, member 4	Mus musculus	13-16
34870866-17	2021	CONCLUSIONS: FXR plays a pivotal role in regulating iron homeostasis, and protects mice against iron hepatotoxicity.	Iron	96-100	nuclear receptor subfamily 1, group H, member 4	Mus musculus	13-16
34870866-18	2021	Targeting FXR may represent a therapeutic strategy for iron overload-associated chronic liver diseases.	Iron	55-59	nuclear receptor subfamily 1, group H, member 4	Mus musculus	10-13
34668997-1	2021	This work introduces an electrochemical aptasensor based on a single-stranded aptamer-Au@Fe-MIL-88 complex for sensitive and selective determination of insulin using differential pulls voltammetry.	Iron	89-91	insulin	Homo sapiens	152-159
34862739-1	2022	Human transferrin receptor 1 (TfR) is necessary for delivery of the iron carrier protein transferrin into cells and can be utilized for targeted delivery across cellular membranes.	Iron	68-72	transferrin	Homo sapiens	89-100
34862739-2	2022	Binding of transferrin to the receptor is regulated by hereditary hemochromatosis protein (HFE), an iron regulatory protein that partly shares a binding site with transferrin on TfR.	Iron	100-104	transferrin	Homo sapiens	11-22
34862739-2	2022	Binding of transferrin to the receptor is regulated by hereditary hemochromatosis protein (HFE), an iron regulatory protein that partly shares a binding site with transferrin on TfR.	Iron	100-104	transferrin	Homo sapiens	163-174
34862195-0	2022	Pharmacological reduction of mitochondrial iron triggers a non-canonical BAX/BAK dependent cell death.	Iron	43-47	BCL2 associated X, apoptosis regulator	Homo sapiens	73-76
34857020-2	2021	The iron stores are determined by the levels of serum ferritin concentration and transferrin saturation.	Iron	4-8	transferrin	Homo sapiens	81-92
34369274-12	2021	Moreover, TFRC activated PTEN induced kinase 1 (PINK1) signaling and induced mitophagy; iron-uptake-induced upregulation of acyl-CoA synthetase long chain family member 4 (ACSL4) was required for mitophagy activation and glutathione peroxidase 4 (GPX4) degradation.	Iron	88-92	acyl-CoA synthetase long chain family member 4	Homo sapiens	124-170
34175430-8	2021	Genes associated with intracellular iron metabolism and homeostasis, such as transferrin receptor 1, divalent metal transporter 1, and ferroportin-1, and showed abnormal expression levels in animal tissues and lung epithelial MLE-12 cells, which responded to BLM stimulation.	Iron	36-40	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	135-148
34402724-0	2021	Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis.	Iron	145-149	interleukin 6	Homo sapiens	0-13
34369274-12	2021	Moreover, TFRC activated PTEN induced kinase 1 (PINK1) signaling and induced mitophagy; iron-uptake-induced upregulation of acyl-CoA synthetase long chain family member 4 (ACSL4) was required for mitophagy activation and glutathione peroxidase 4 (GPX4) degradation.	Iron	88-92	acyl-CoA synthetase long chain family member 4	Homo sapiens	172-177
34402724-10	2021	We found that IL-6 decreased the activity, promoted lipid peroxidation, disrupted iron homeostasis of BEAS-2B cells, and induced iron death in bronchial epithelial BEAS-2B cells.	Iron	82-86	interleukin 6	Homo sapiens	14-18
34402724-12	2021	Overall, IL-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species (ROS)-dependent lipid peroxidation and disrupting iron homeostasis.	Iron	151-155	interleukin 6	Homo sapiens	9-13
34611951-11	2021	Finally, we showed that Runx3 enhanced the activity of the BMP6 promoter by responding to iron stimuli in the hepatocytes.	Iron	90-94	bone morphogenetic protein 6	Homo sapiens	59-63
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	51-55	microRNA let-7d	Homo sapiens	76-82
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	51-55	microRNA 200b	Homo sapiens	97-105
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	118-122	microRNA let-7d	Homo sapiens	76-82
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	118-122	microRNA 200b	Homo sapiens	97-105
34432101-7	2021	And by extension, targeting miR-let-7d, miR-122, and miR-200 might serve as novel sensitive, specific and non-invasive predictor biomarkers for cellular damage under condition of tissue iron excess.	Iron	186-190	microRNA let-7d	Homo sapiens	32-38
34265727-4	2021	Fe(V)/Fe(IV) and  OH were the main active oxidizing species for AT degradation in the Fe(VI)/BC-2 group and contributed to 70% and 24%, respectively, of degradation.	Iron	6-8	FEV transcription factor, ETS family member	Homo sapiens	0-5
34800311-0	2021	Vam6/Vps39/TRAP1-domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans.	Iron	64-68	VPS39 HOPS complex subunit	Mus musculus	0-4
34800311-5	2021	C. neoformans encodes a second Vam6/Vps39/TRAP1 domain-containing protein designated Vam6/Vlp1, and we found that this protein is also required for robust growth on heme as well as on inorganic iron sources.	Iron	194-198	VPS39 HOPS complex subunit	Mus musculus	31-35
34800311-5	2021	C. neoformans encodes a second Vam6/Vps39/TRAP1 domain-containing protein designated Vam6/Vlp1, and we found that this protein is also required for robust growth on heme as well as on inorganic iron sources.	Iron	194-198	VPS39 HOPS complex subunit	Mus musculus	85-89
34851004-0	2022	Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding.	Iron	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
34265727-5	2021	The formation of  OH and Fe(V)/Fe(IV) was mainly due to the persistent free radicals and reducing groups on the surface of BC-2.	Iron	31-33	FEV transcription factor, ETS family member	Homo sapiens	25-30
34323808-3	2021	The efficiencies of Pb(II) and RIF removal by Fe/Ni-rGO were 87.5 and 96.8%, respectively.	Iron	46-48	submaxillary gland androgen regulated protein 3B	Homo sapiens	20-26
34000978-8	2021	In one case, iron chelation therapy (ICT) resulted in parallel decreases in serum ferritin and CD34+ cells siROS.Conclusion: Our findings established the siROS profile in early hematopoietic cells of MDS patients and its relationship with blast count and iron overload.	Iron	13-17	CD34 molecule	Homo sapiens	95-99
34515590-5	2021	Most charmingly, the iron mimic cyclic peptide CRTIGPSVC (CRT) was modified on MMB4@MDZ surfaces to produce CRT-MMB4@MDZ which was endowed with ability to absorb transferrin (Tf)-abundant corona.	Iron	21-25	transferrin	Homo sapiens	162-173
34753406-8	2021	The concentrations of both intracellular iron and reactive oxygen species (ROS) in CD34+ cells of bone marrow were higher in the IOL group than the NIOL group, respectively (P = 0.0426; P = 0.0185).	Iron	41-45	CD34 molecule	Homo sapiens	83-87
34592676-8	2021	In addition, serum iron had significant, inverse associations with insulin and HOMA-IR.	Iron	19-23	insulin	Homo sapiens	67-74
34740612-0	2021	Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron sensing pathway in vitro.	Iron	108-112	bone morphogenetic protein 6	Homo sapiens	0-28
34740612-1	2021	Liver sinusoidal endothelial cells (LSECs) derived bone morphogenetic protein 6 (BMP6) and the BMP6/SMAD signaling pathway are essential for expression of hepcidin, the secretion of which is considered the systemic master switch of iron homeostasis.	Iron	232-236	bone morphogenetic protein 6	Homo sapiens	51-79
34740612-1	2021	Liver sinusoidal endothelial cells (LSECs) derived bone morphogenetic protein 6 (BMP6) and the BMP6/SMAD signaling pathway are essential for expression of hepcidin, the secretion of which is considered the systemic master switch of iron homeostasis.	Iron	232-236	bone morphogenetic protein 6	Homo sapiens	81-85
34740612-1	2021	Liver sinusoidal endothelial cells (LSECs) derived bone morphogenetic protein 6 (BMP6) and the BMP6/SMAD signaling pathway are essential for expression of hepcidin, the secretion of which is considered the systemic master switch of iron homeostasis.	Iron	232-236	bone morphogenetic protein 6	Homo sapiens	95-99
34753406-11	2021	CONCLUSION: Elevated intracellular iron and ROS in CD34+ cells of bone marrow could accelerate the abnormal proliferation of blasts.	Iron	35-39	CD34 molecule	Homo sapiens	51-55
34341912-6	2021	Iron chelators, such as deferoxamine and albumin, have been used to reduce the free radical injury that ensues from erythrocyte lysis.	Iron	0-4	albumin	Homo sapiens	41-48
34547407-0	2021	Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic beta-cells.	Iron	115-119	inhibitor of DNA binding 3, HLH protein	Homo sapiens	74-77
34547407-8	2021	RNA-sequencing analysis in iron overloaded INS-1 cells identified Id1 and Id3 as the top down-regulated genes, while Hmox1 was the top upregulated.	Iron	27-31	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	66-69
34547407-8	2021	RNA-sequencing analysis in iron overloaded INS-1 cells identified Id1 and Id3 as the top down-regulated genes, while Hmox1 was the top upregulated.	Iron	27-31	inhibitor of DNA binding 3, HLH protein	Rattus norvegicus	74-77
34547407-12	2021	Our findings suggest that HMOX1, ID1 and ID3 define the response mechanism against iron-overload-induced stress in beta-cells.	Iron	83-87	inhibitor of DNA binding 3, HLH protein	Homo sapiens	41-44
34340090-3	2021	Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT.	Iron	107-109	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	12-15
34612534-0	2021	Root responses to aluminium and iron stresses require the SIZ1 SUMO ligase to modulate the STOP1 transcription factor.	Iron	32-36	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	91-96
34612534-1	2021	STOP1, an Arabidopsis transcription factor favouring root growth tolerance against Al toxicity, acts in the response to iron under low Pi (-Pi).	Iron	120-124	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	0-5
34612534-2	2021	Previous studies have shown that Al and Fe regulate the stability and accumulation of STOP1 in roots, and that the STOP1 protein is sumoylated by an unknown E3 ligase.	Iron	40-42	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	86-91
34612534-4	2021	Mutations in SIZ1 increase the expression of ALMT1 (a direct target of STOP1) and root growth responses to Al and Fe stress in a STOP1-dependent manner.	Iron	114-116	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	71-76
34612534-4	2021	Mutations in SIZ1 increase the expression of ALMT1 (a direct target of STOP1) and root growth responses to Al and Fe stress in a STOP1-dependent manner.	Iron	114-116	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	129-134
34340090-0	2021	Knockout of FER decreases cadmium concentration in roots of Arabidopsis thaliana by inhibiting the pathway related to iron uptake.	Iron	118-122	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	12-15
34340090-6	2021	Furthermore, increased Fe supplementation had little effect on the Cd tolerance of fer-4 mutants, but clearly improved the Cd tolerance of wild-type seedlings, showing that the alleviation of Cd toxicity by Fe depends on the action of FER.	Iron	23-25	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	235-238
34340090-3	2021	Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT.	Iron	101-105	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	12-15
34340090-6	2021	Furthermore, increased Fe supplementation had little effect on the Cd tolerance of fer-4 mutants, but clearly improved the Cd tolerance of wild-type seedlings, showing that the alleviation of Cd toxicity by Fe depends on the action of FER.	Iron	207-209	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	235-238
34340090-7	2021	Taken together, the findings demonstrate that the knockout of FER might provide a strategy to reduce Cd contamination and improve the Cd tolerance in plants by regulating the pathways related to Fe uptake.	Iron	195-197	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	62-65
34873429-0	2021	Changes in Hepcidin Levels in an Animal Model of Anemia of Chronic Inflammation: Mechanistic Insights Related to Iron Supplementation and Hepcidin Regulation.	Iron	113-117	hepcidin antimicrobial peptide	Rattus norvegicus	11-19
34676621-5	2021	S-Fe bond in L-cys-Fe complexes promoted the electron transfer between nFe3 O4 core and the solution, iron and iron at the interface, thereby promoting the Fe3+ /Fe2+ cycle and the catalytic capacity of nFe3 O4 .	Iron	2-4	nuclear receptor subfamily 2 group F member 2	Homo sapiens	71-75
34676621-5	2021	S-Fe bond in L-cys-Fe complexes promoted the electron transfer between nFe3 O4 core and the solution, iron and iron at the interface, thereby promoting the Fe3+ /Fe2+ cycle and the catalytic capacity of nFe3 O4 .	Iron	102-106	nuclear receptor subfamily 2 group F member 2	Homo sapiens	71-75
34676621-5	2021	S-Fe bond in L-cys-Fe complexes promoted the electron transfer between nFe3 O4 core and the solution, iron and iron at the interface, thereby promoting the Fe3+ /Fe2+ cycle and the catalytic capacity of nFe3 O4 .	Iron	111-115	nuclear receptor subfamily 2 group F member 2	Homo sapiens	71-75
34873429-1	2021	We examined changes in hepcidin (closely associated with anemia of chronic inflammation (ACI)) and upstream regulatory pathways after intravenous (IV) iron supplementation in an ACI animal model.	Iron	151-155	hepcidin antimicrobial peptide	Rattus norvegicus	23-31
34873429-7	2021	In CFA-saline rats, hepatic hepcidin and ferritin levels increased compared with those in control rats and were further increased in CFA-iron rats.	Iron	137-141	hepcidin antimicrobial peptide	Rattus norvegicus	28-36
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	180-184	interleukin 6	Rattus norvegicus	38-42
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	180-184	signal transducer and activator of transcription 3	Homo sapiens	43-47
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	244-248	interleukin 6	Rattus norvegicus	38-42
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	244-248	signal transducer and activator of transcription 3	Homo sapiens	43-47
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	16-20	signal transducer and activator of transcription 3	Homo sapiens	47-53
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	123-127	signal transducer and activator of transcription 3	Homo sapiens	83-89
34873429-12	2021	In ACI rats, IV iron supplementation did not recover Hb within three days despite an increase in hepatic ferritin levels, which might be attributable to an additional increase in hepcidin levels that was already upregulated under ACI conditions.	Iron	16-20	hepcidin antimicrobial peptide	Rattus norvegicus	179-187
34873429-13	2021	Both STAT-3 phosphorylation and SMAD1/5 phosphorylation were associated with hepcidin upregulation after IV iron treatment, and this seems to be linked to iron-induced oxidative stress.	Iron	108-112	hepcidin antimicrobial peptide	Rattus norvegicus	77-85
34873429-13	2021	Both STAT-3 phosphorylation and SMAD1/5 phosphorylation were associated with hepcidin upregulation after IV iron treatment, and this seems to be linked to iron-induced oxidative stress.	Iron	155-159	hepcidin antimicrobial peptide	Rattus norvegicus	77-85
34888245-0	2021	High-LET Carbon and Iron Ions Elicit a Prolonged and Amplified p53 Signaling and Inflammatory Response Compared to low-LET X-Rays in Human Peripheral Blood Mononuclear Cells.	Iron	20-24	tumor protein p53	Homo sapiens	63-66
34819512-4	2021	We find that the charge-coupled substitution AMg2+  + BSi4+    AFe3+(high-spin) + BAl3+ is predominant in the incorporation of Fe and Al into the practically eightfold-coordinated A-site and the sixfold-coordinated B-site in bridgmanite structure.	Iron	127-129	poly(ADP-ribose) polymerase family member 15	Homo sapiens	82-86
34756250-1	2021	Transferrin (Trf) is a new type of active drug targeting carrier and disease biomarker that regulates the balance of iron ions in human body.	Iron	117-121	transferrin	Homo sapiens	0-11
34756250-1	2021	Transferrin (Trf) is a new type of active drug targeting carrier and disease biomarker that regulates the balance of iron ions in human body.	Iron	117-121	transferrin	Homo sapiens	13-16
34811513-8	2021	Furthermore, we showed that iron played a critical role in mediating Clk1 deficiency-induced alteration in DAT expression, presumably via upstream HIF-1alpha.	Iron	28-32	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	107-110
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	98-102
34894263-10	2022	Correspondingly, the expression of Fe uptake genes increased in the tpr1 tpr4 tpl mutant.	Iron	35-37	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	73-77
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	14-18	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	83-96
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	14-18	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	98-102
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	69-73	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	83-96
34728613-0	2021	LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer.	Iron	92-96	prominin 2	Mus musculus	76-81
34799629-2	2021	De novo heterozygous mutations in WDR45 have been known to cause beta-propeller protein-associated neurodegeneration (BPAN), a subtype of neurodegeneration with brain iron accumulation (NBIA).	Iron	167-171	WD repeat domain 45	Mus musculus	34-39
34801431-3	2022	When iron loading exceeds transferrin binding capacity, labile, non-transferrin-bound iron (NTBI) appears and causes organ injury.	Iron	5-9	transferrin	Homo sapiens	68-79
34801431-3	2022	When iron loading exceeds transferrin binding capacity, labile, non-transferrin-bound iron (NTBI) appears and causes organ injury.	Iron	86-90	transferrin	Homo sapiens	26-37
34801431-3	2022	When iron loading exceeds transferrin binding capacity, labile, non-transferrin-bound iron (NTBI) appears and causes organ injury.	Iron	86-90	transferrin	Homo sapiens	68-79
34780475-4	2021	AIM: The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.	Iron	101-105	transmembrane serine protease 6	Homo sapiens	57-64
34790244-8	2021	Furthermore, western blot analysis showed that the expression of iron metabolism-related protein FPN-1 was higher in the intervention group than in the model group after reperfusion.	Iron	65-69	solute carrier family 40 member 1	Rattus norvegicus	97-102
34735495-10	2021	Hub genes (FPR3, C3AR1, CD14, ITGB2, RAC2 and ITGAM) related to iron death in diabetic nephropathy were obtained through gene expression differential analysis between different subtypes.	Iron	64-68	Rac family small GTPase 2	Homo sapiens	37-41
34726258-1	2022	Transfusion of storage-damaged red blood cells (RBCs) increases non-transferrin-bound iron (NTBI) levels in humans.	Iron	86-90	transferrin	Homo sapiens	68-79
34714626-2	2021	Central to cellular oxygen sensing is factor-inhibiting HIF-1alpha (FIH), an alpha-ketoglutarate (alphaKG)/non-heme iron(II)-dependent dioxygenase that hydroxylates a specific asparagine residue of hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	116-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	198-229
34714626-2	2021	Central to cellular oxygen sensing is factor-inhibiting HIF-1alpha (FIH), an alpha-ketoglutarate (alphaKG)/non-heme iron(II)-dependent dioxygenase that hydroxylates a specific asparagine residue of hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	116-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-241
34728613-10	2021	Elevated PROM2 in cells was associated with attenuated ferroptosis through iron export, formation of multivesicular bodies and less mitochondrial abnormalities.	Iron	75-79	prominin 2	Mus musculus	9-14
34728613-11	2021	We demonstrated that RP11-89 is a novel tumorigenic regulator that inhibits ferroptosis via PROM2-activated iron export.	Iron	108-112	prominin 2	Mus musculus	92-97
34479949-1	2021	BACKGROUND: Experimental studies suggest that iron overload might increase pancreatic cancer (PC) risk.	Iron	46-50	pyruvate carboxylase	Homo sapiens	94-96
34649350-3	2021	Activation of PPARdelta by the specific ligand GW501516 led to a dose-dependent decrease in ferroptotic cell death triggered by xCT deficiency, along with decreased levels of intracellular iron accumulation and lipid peroxidation.	Iron	189-193	peroxisome proliferator activator receptor delta	Mus musculus	14-23
34479949-2	2021	We evaluated whether prediagnostic hemochromatosis and iron-overload diseases, including sideroblastic and congenital dyserythropoietic anemias and non-alcoholic related chronic liver disease (NACLD), were associated with PC risk in older adults.	Iron	55-59	pyruvate carboxylase	Homo sapiens	222-224
34479949-12	2021	IMPACT: These results partly support the hypothesis that iron-overload diseases increases PC risk.	Iron	57-61	pyruvate carboxylase	Homo sapiens	90-92
34455040-0	2021	Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1.	Iron	54-58	poly(rC) binding protein 1	Mus musculus	69-74
34119736-3	2021	The citrate iron complex of Fe(II)(Cit)- played the key role for the degradation process since it could quickly react with the generated H2O2 to produce free radicals in the Bi/Fe0+NaCA + CA system, which broadened the applicable pH range of the traditional Fenton reaction and promoted the oxidative degradation process of ATR.	Iron	12-16	nascent polypeptide associated complex subunit alpha	Homo sapiens	181-185
34435561-7	2021	Animal experiments demonstrated that MC-LR resulted in microcytic anemia, which is associated with inflammation, dysregulation of iron homeostasis, and erythropoiesis.	Iron	130-134	methylcholanthrene lymphoma resistance	Mus musculus	37-42
34346561-10	2021	RESULTS: Ang II-induced hypertensive mice showed increased iron accumulation in the brain and expanded secondary hemorrhage after ICH modeling.	Iron	59-63	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	9-15
34346561-12	2021	Mechanistically, iron exacerbated the loss of contractile cerebral vascular smooth muscle cells (VSMCs), aggravated blood-brain barrier (BBB) leakage in Ang II-induced hypertensive mice, and increased glial and MMP9 accumulation after ICH.	Iron	17-21	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	153-159
34346561-13	2021	CONCLUSION: Iron overload plays a key role in secondary bleeding after ICH in Ang II-induced hypertensive mice.	Iron	12-16	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	78-84
34346561-14	2021	Iron chelation during the process of Ang II-induced hypertension suppresses secondary bleeding after ICH.	Iron	0-4	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	37-43
34455040-3	2021	Poly r(C) binding protein 1 (PCBP1) is an essential, multifunctional protein that binds both iron and nucleic acids, regulating the fate of both.	Iron	93-97	poly(rC) binding protein 1	Mus musculus	0-27
34455040-3	2021	Poly r(C) binding protein 1 (PCBP1) is an essential, multifunctional protein that binds both iron and nucleic acids, regulating the fate of both.	Iron	93-97	poly(rC) binding protein 1	Mus musculus	29-34
34455040-4	2021	As an iron chaperone, PCBP1 binds cytosolic iron and delivers it to iron enzymes for activation and to ferritin for storage.	Iron	6-10	poly(rC) binding protein 1	Mus musculus	22-27
34455040-4	2021	As an iron chaperone, PCBP1 binds cytosolic iron and delivers it to iron enzymes for activation and to ferritin for storage.	Iron	44-48	poly(rC) binding protein 1	Mus musculus	22-27
34790664-4	2021	STEAP3 was previously proved to serve a key regulator in ferroptosis via mediating the iron metabolism.	Iron	87-91	STEAP3 metalloreductase	Homo sapiens	0-6
34455040-4	2021	As an iron chaperone, PCBP1 binds cytosolic iron and delivers it to iron enzymes for activation and to ferritin for storage.	Iron	68-72	poly(rC) binding protein 1	Mus musculus	22-27
34455040-5	2021	Mice deleted for PCBP1 in the liver exhibit dysregulated iron balance, with lower levels of liver iron stores and iron enzymes, but higher levels of chemically-reactive iron.	Iron	57-61	poly(rC) binding protein 1	Mus musculus	17-22
34455040-5	2021	Mice deleted for PCBP1 in the liver exhibit dysregulated iron balance, with lower levels of liver iron stores and iron enzymes, but higher levels of chemically-reactive iron.	Iron	98-102	poly(rC) binding protein 1	Mus musculus	17-22
34455040-5	2021	Mice deleted for PCBP1 in the liver exhibit dysregulated iron balance, with lower levels of liver iron stores and iron enzymes, but higher levels of chemically-reactive iron.	Iron	114-118	poly(rC) binding protein 1	Mus musculus	17-22
34455040-5	2021	Mice deleted for PCBP1 in the liver exhibit dysregulated iron balance, with lower levels of liver iron stores and iron enzymes, but higher levels of chemically-reactive iron.	Iron	169-173	poly(rC) binding protein 1	Mus musculus	17-22
34146434-6	2021	In PE and FGR, iron homeostasis is changed, and iron levels significantly correlates with severity of disease.	Iron	15-19	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
34508722-1	2021	Human transferrin (Tf) is an iron-binding blood plasma glycoprotein that controls free iron in biological fluids.	Iron	29-33	transferrin	Homo sapiens	6-17
34508722-1	2021	Human transferrin (Tf) is an iron-binding blood plasma glycoprotein that controls free iron in biological fluids.	Iron	87-91	transferrin	Homo sapiens	6-17
34302234-2	2021	Iron surplus load to increase non-transferrin bound iron (NTBI), and NTBI promotes cancer progression and influences microbiota.	Iron	0-4	transferrin	Homo sapiens	34-45
34302234-2	2021	Iron surplus load to increase non-transferrin bound iron (NTBI), and NTBI promotes cancer progression and influences microbiota.	Iron	52-56	transferrin	Homo sapiens	34-45
34302234-4	2021	METHODS: We evaluated preoperative iron and transferrin saturation (TSAT), which was calculated as iron divided by total iron-binding capacity, in 327 patients who underwent surgery for Stage II-III CRC.	Iron	99-103	transferrin	Homo sapiens	44-55
34146434-6	2021	In PE and FGR, iron homeostasis is changed, and iron levels significantly correlates with severity of disease.	Iron	48-52	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
34146434-7	2021	The normal increase in plasma volume taking place during pregnancy is less for PE and FGR and therefore have different impact on e.g., iron concentration compared to normal pregnancy.	Iron	135-139	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
34146434-10	2021	Underlying placental pathology in PE with and without FGR might be amplified by iron and heme overload causing oxidative stress and ferroptosis.	Iron	80-84	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	54-57
34707288-6	2021	Cells lacking both SLC25A39 and its paralogue SLC25A40 exhibit defects in the activity and stability of proteins containing iron-sulfur clusters.	Iron	124-128	solute carrier family 25 member 40	Homo sapiens	46-54
34324880-1	2021	OBJECTIVES: To test whether an increased iron dose is associated with improved neurodevelopment as assessed by the Bayley Scales of Infant Development (BSID-III) among infants enrolled in the Preterm Erythropoietin (Epo) Neuroprotection Trial (PENUT).	Iron	41-45	erythropoietin	Homo sapiens	200-214
34324880-1	2021	OBJECTIVES: To test whether an increased iron dose is associated with improved neurodevelopment as assessed by the Bayley Scales of Infant Development (BSID-III) among infants enrolled in the Preterm Erythropoietin (Epo) Neuroprotection Trial (PENUT).	Iron	41-45	erythropoietin	Homo sapiens	216-219
34716241-6	2021	The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis.	Iron	122-126	heme oxygenase 1	Mus musculus	87-91
34700146-6	2021	We then used a GFP-CD63 labeled THP-1 macrophage model exposed to crocidolite/iron, which generated EVs under ferroptotic process.	Iron	78-82	CD63 antigen	Mus musculus	19-23
34700146-6	2021	We then used a GFP-CD63 labeled THP-1 macrophage model exposed to crocidolite/iron, which generated EVs under ferroptotic process.	Iron	78-82	GLI family zinc finger 2	Homo sapiens	32-37
34656823-3	2021	Within the electron transport chain, Fe-S clusters play a critical role in transporting electrons through Complexes I, II and III to cytochrome c, before subsequent transfer to molecular oxygen.	Iron	37-41	cytochrome c, somatic	Homo sapiens	133-145
34217897-9	2021	Substantial Fe dependent cell injury (decreased MTT uptake), and Fe independent increases in HO-1/IL-6 mRNA expression were observed.	Iron	65-67	heme oxygenase 1	Mus musculus	93-97
34217897-9	2021	Substantial Fe dependent cell injury (decreased MTT uptake), and Fe independent increases in HO-1/IL-6 mRNA expression were observed.	Iron	65-67	interleukin 6	Mus musculus	98-102
34706618-1	2021	The BMP6 protein (Bone Morphogenetic Protein 6) is part of the superfamily of transforming growth factor-beta (TGF-beta) ligands, participates in iron homeostasis, inhibits invasion by increasing adhesions and cell-cell type interactions and induces angiogenesis directly on vascular endothelial cells.	Iron	146-150	bone morphogenetic protein 6	Homo sapiens	4-8
34772023-1	2021	In this paper, we study the electrical properties of new hybrid magnetorheological suspensions (hMRSs) and propose a theoretical model to explain the dependence of the electric capacitance on the iron volumetric fraction, PhiFe, of the dopants and on the external magnetic field.	Iron	196-200	MRSS	Homo sapiens	96-101
34706618-1	2021	The BMP6 protein (Bone Morphogenetic Protein 6) is part of the superfamily of transforming growth factor-beta (TGF-beta) ligands, participates in iron homeostasis, inhibits invasion by increasing adhesions and cell-cell type interactions and induces angiogenesis directly on vascular endothelial cells.	Iron	146-150	bone morphogenetic protein 6	Homo sapiens	18-46
34663434-3	2021	Previous studies have found that the TCM Yi Gong San (YGS) can reduce the expression of transferrin by inhibiting hepcidin overexpression caused by inflammation, promote the outward transfer of intracellular iron, and improve the symptoms of anemia.	Iron	208-212	transferrin	Homo sapiens	88-99
34769084-0	2021	Iron Accumulation and Changes in Cellular Organelles in WDR45 Mutant Fibroblasts.	Iron	0-4	WD repeat domain 45	Homo sapiens	56-61
34769084-2	2021	In neurodegeneration accompanied by brain iron accumulation, we reported a specific point mutation, c.974-1G>A in WD Repeat Domain 45 (WDR45), showing iron accumulation in the brain, and autophagy defects in the fibroblasts.	Iron	42-46	WD repeat domain 45	Homo sapiens	114-133
34769084-2	2021	In neurodegeneration accompanied by brain iron accumulation, we reported a specific point mutation, c.974-1G>A in WD Repeat Domain 45 (WDR45), showing iron accumulation in the brain, and autophagy defects in the fibroblasts.	Iron	42-46	WD repeat domain 45	Homo sapiens	135-140
34769084-2	2021	In neurodegeneration accompanied by brain iron accumulation, we reported a specific point mutation, c.974-1G>A in WD Repeat Domain 45 (WDR45), showing iron accumulation in the brain, and autophagy defects in the fibroblasts.	Iron	151-155	WD repeat domain 45	Homo sapiens	114-133
34769084-2	2021	In neurodegeneration accompanied by brain iron accumulation, we reported a specific point mutation, c.974-1G>A in WD Repeat Domain 45 (WDR45), showing iron accumulation in the brain, and autophagy defects in the fibroblasts.	Iron	151-155	WD repeat domain 45	Homo sapiens	135-140
34831070-0	2021	Iron Metabolism as a Potential Mechanism for Inducing TRAIL-Mediated Extrinsic Apoptosis Using Methylsulfonylmethane in Embryonic Cancer Stem Cells.	Iron	0-4	TNF superfamily member 10	Homo sapiens	54-59
34831070-7	2021	Inhibition of iron metabolism-dependent reactive oxygen species (ROS) generation takes part in TRAIL-mediated apoptosis induction by MSM.	Iron	14-18	TNF superfamily member 10	Homo sapiens	95-100
34831070-8	2021	Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis.	Iron	12-16	mitogen-activated protein kinase 14	Homo sapiens	50-53
34831070-8	2021	Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis.	Iron	12-16	tumor protein p53	Homo sapiens	54-57
34831070-8	2021	Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis.	Iron	12-16	mitogen-activated protein kinase 1	Homo sapiens	58-61
34831070-8	2021	Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis.	Iron	12-16	TNF superfamily member 10	Homo sapiens	186-191
34786173-13	2021	CONCLUSION: Iron directly blocks hepatocellular hepcidin signaling through the BMP/SMAD pathway but independent of STAT3.	Iron	12-16	bone morphogenetic protein 6	Homo sapiens	79-82
34805801-6	2021	Nfs1p is required for the formation of Fe-S clusters, which are essential cofactors for DNA repair enzymes.	Iron	39-43	cysteine desulfurase	Saccharomyces cerevisiae S288C	0-5
34695787-11	2021	Vitamin A concentration was lower in the Nowshera District, whereas serum iron and zinc were lower in the Dera Ismail Khan District.	Iron	74-78	deoxyribose-phosphate aldolase	Homo sapiens	106-110
34147035-7	2021	In contrast, genetically instrumented transferrin, a marker of reduced iron status, was inversely associated with T2D (OR: 0.91; 95% CI: 0.87-0.96).	Iron	71-75	transferrin	Homo sapiens	38-49
34733841-9	2021	Notably, ALKBH5 overexpression led to a significant reduction in intracellular iron levels as well as cell migratory and invasive abilities, which could be rescued by knocking down FBXL5.	Iron	79-83	F-box and leucine rich repeat protein 5	Homo sapiens	181-186
34648123-3	2021	Intra- and extracellular iron affinity and antioxidant activity, as well as the ability to scavenge iron from holo-transferrin, were studied in physiologically relevant settings.	Iron	100-104	transferrin	Homo sapiens	115-126
34332918-7	2021	Moreover, ACSL4 behaves as a crucial regulator in ferroptosis that is defined as a cell death process caused by iron-dependent peroxidation of lipids.	Iron	112-116	acyl-CoA synthetase long chain family member 4	Homo sapiens	10-15
34675613-8	2021	Serum ferritin (SF) assays were conducted by electrochemiluminescence immunoassay method, while transferrin saturation (TS) was calculated by dividing serum iron by the binding capacity.	Iron	157-161	transferrin	Homo sapiens	96-107
34648132-6	2021	Furthermore, a lack of miR-7-5p expression led to increased levels of transferrin receptor, promoting the uptake of iron and production of lipid reactive oxygen species and demonstrating that DOX-induced ferroptosis occurs in AC16 cells.	Iron	116-120	microRNA 7-2	Homo sapiens	23-31
34625812-9	2022	However, there was a significant increase in the placental expression of the oxidative stress marker heme oxygenase 1 in iron replete pregnant mice treated with ferrous sulfate when compared to iron replete pregnant mice gavaged with IHAT (96.9%, P < 0.05).	Iron	121-125	heme oxygenase 1	Mus musculus	101-117
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	27-31	transferrin	Homo sapiens	85-96
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	27-31	transferrin	Homo sapiens	98-100
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	27-31	transferrin	Homo sapiens	210-221
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	49-53	transferrin	Homo sapiens	85-96
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	49-53	transferrin	Homo sapiens	98-100
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	49-53	transferrin	Homo sapiens	210-221
34679725-1	2021	Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status.	Iron	40-44	bone morphogenetic protein 6	Homo sapiens	135-140
34679725-1	2021	Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status.	Iron	182-186	bone morphogenetic protein 6	Homo sapiens	105-133
34679725-1	2021	Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status.	Iron	182-186	bone morphogenetic protein 6	Homo sapiens	135-140
34622990-4	2021	Anti-osteocalcin antibody was attached on the electrode through the silane-modified iron material.	Iron	84-88	bone gamma-carboxyglutamate protein	Homo sapiens	5-16
34116221-4	2021	Here, we show that reduced expression of Arabidopsis YABBY transcription factor INNER NO OUTER (INO) increases embryonic Fe accumulation, while transgenic overexpression of INO has opposite effect.	Iron	121-123	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	80-94
34612205-5	2021	Biochemical studies reveal that Plasmodium mACP binds and stabilizes the Isd11-Nfs1 complex required for Fe-S cluster biosynthesis, despite lacking the Ppant group required for this association in other eukaryotes, and knockdown of parasite mACP causes loss of Nfs1 and the Rieske Fe-S protein in ETC Complex III.	Iron	105-109	LYR motif containing 4	Homo sapiens	73-78
34171482-8	2021	Further transcriptomic, FT-IR and Fe desorption kinetic analyses coincidently suggested that Cdi mediates apoplastic Fe reallocation by extensive modulation of cell wall components and consequently the Fe adsorption capacity of cell wall.	Iron	34-36	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	93-96
34116221-4	2021	Here, we show that reduced expression of Arabidopsis YABBY transcription factor INNER NO OUTER (INO) increases embryonic Fe accumulation, while transgenic overexpression of INO has opposite effect.	Iron	121-123	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	96-99
34171482-8	2021	Further transcriptomic, FT-IR and Fe desorption kinetic analyses coincidently suggested that Cdi mediates apoplastic Fe reallocation by extensive modulation of cell wall components and consequently the Fe adsorption capacity of cell wall.	Iron	202-204	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	93-96
34116221-5	2021	INO is highly expressed during early seed development, and that decreased expression of INO increases the expression of NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1 (NRAMP1), a gene encoding a transporter contributing to Fe loading into the seed.	Iron	227-229	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	0-3
34116221-5	2021	INO is highly expressed during early seed development, and that decreased expression of INO increases the expression of NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1 (NRAMP1), a gene encoding a transporter contributing to Fe loading into the seed.	Iron	227-229	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	88-91
34116221-6	2021	The relatively high embryonic Fe accumulation conferred by decreased expression of INO is rescued by the nramp1 loss-of-function mutation.	Iron	30-32	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	83-86
34116221-8	2021	Moreover, we show that excessive Fe loading into developing seeds in ino mutants produces more oxidative damage, leading to increased cell death and seed abortion, a phenotype that can be rescued by nramp1 mutation.	Iron	33-35	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	69-72
34116221-9	2021	Taken together, these results indicate that INO plays an important role in safeguarding reproduction by reducing Fe loading into developing seeds via repression of NRAMP1 expression.	Iron	113-115	Plant-specific transcription factor YABBY family protein	Arabidopsis thaliana	44-47
34547129-9	2021	Our results demonstrate the counteracting effects of overexpression of mitochondrial aconitase (ACO2, a tricarboxylic acid cycle enzyme) or cytosolic aconitase (ACO1, an iron regulatory protein) on IL-1beta secretion and altered iron metabolism.	Iron	229-233	aconitase 2	Homo sapiens	71-94
34224969-1	2021	Herein, a kind of novel multi-layer core-shell nanocomposites (NSPN) was prepared by employing SiO2 and polyvinylpyrrolidone (PVP) polymers as modifiers and amino-functionalized metal-organic frameworks (NH2-MIL101(Fe)) as coating.	Iron	215-217	sarcospan	Homo sapiens	63-67
34790739-3	2021	Methods: Genetic summary statistics of the four biomarkers (serum iron, ferritin, transferrin saturation, and transferrin) of iron status and PLC were retrieved from two independent genome-wide association studies (GWAS) that had been performed in European populations.	Iron	126-130	transferrin	Homo sapiens	82-93
34790739-3	2021	Methods: Genetic summary statistics of the four biomarkers (serum iron, ferritin, transferrin saturation, and transferrin) of iron status and PLC were retrieved from two independent genome-wide association studies (GWAS) that had been performed in European populations.	Iron	126-130	transferrin	Homo sapiens	110-121
34136984-0	2021	Effects of acute iron overload on Nrf2-related glutathione metabolism in rat brain.	Iron	17-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
34136984-6	2021	Nuclear Nrf2/cytosolic Nrf2 ratios showed enhancement (p < 0.05) after 6 h of Fe overload, suggesting a greater translocation of the factor to the nucleus.	Iron	78-80	NFE2 like bZIP transcription factor 2	Rattus norvegicus	8-12
34136984-6	2021	Nuclear Nrf2/cytosolic Nrf2 ratios showed enhancement (p < 0.05) after 6 h of Fe overload, suggesting a greater translocation of the factor to the nucleus.	Iron	78-80	NFE2 like bZIP transcription factor 2	Rattus norvegicus	23-27
34136984-8	2021	It is concluded that acute Fe overload induces oxidative stress in rat brain with the concomitant lipid peroxidation increase and GSH depletion, leading to the elevation of Nrf2-controlled GPx, GPx-Se and GST protein expression as a protective adaptive response.	Iron	27-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	173-177
34547129-9	2021	Our results demonstrate the counteracting effects of overexpression of mitochondrial aconitase (ACO2, a tricarboxylic acid cycle enzyme) or cytosolic aconitase (ACO1, an iron regulatory protein) on IL-1beta secretion and altered iron metabolism.	Iron	229-233	aconitase 2	Homo sapiens	96-100
34410492-3	2021	This genomic perspective started unveiling the relevance of Italy to understand the post-Last Glacial Maximum (LGM) re-peopling of Europe, the earlier phase of the Neolithic westward migrations, and its linking role between Eastern and Western Mediterranean areas after the Iron Age.	Iron	274-278	renin binding protein	Homo sapiens	279-282
34480898-0	2021	Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFalpha-mediated apoptosis.	Iron	0-4	tumor necrosis factor	Homo sapiens	79-87
34480898-1	2021	In plasma, iron is normally bound to transferrin, the principal protein in blood responsible for binding and transporting iron throughout the body.	Iron	11-15	transferrin	Homo sapiens	37-48
34480898-1	2021	In plasma, iron is normally bound to transferrin, the principal protein in blood responsible for binding and transporting iron throughout the body.	Iron	122-126	transferrin	Homo sapiens	37-48
34480898-2	2021	However, in conditions of iron overload when the iron-binding capacity of transferrin is exceeded, non-transferrin-bound iron (NTBI) appears in plasma.	Iron	26-30	transferrin	Homo sapiens	74-85
34480898-2	2021	However, in conditions of iron overload when the iron-binding capacity of transferrin is exceeded, non-transferrin-bound iron (NTBI) appears in plasma.	Iron	49-53	transferrin	Homo sapiens	74-85
34480898-2	2021	However, in conditions of iron overload when the iron-binding capacity of transferrin is exceeded, non-transferrin-bound iron (NTBI) appears in plasma.	Iron	121-125	transferrin	Homo sapiens	74-85
34480898-2	2021	However, in conditions of iron overload when the iron-binding capacity of transferrin is exceeded, non-transferrin-bound iron (NTBI) appears in plasma.	Iron	121-125	transferrin	Homo sapiens	103-114
34480898-6	2021	We showed by RNA-Seq that iron loading alters lipid homeostasis in HUVECs by inducing sterol regulatory element-binding protein 2-mediated cholesterol biosynthesis.	Iron	26-30	sterol regulatory element binding transcription factor 2	Homo sapiens	86-129
34195939-3	2021	We tested the hypotheses that cerebrospinal fluid (CSF) heavy-chain ferritin (Fth1) and transferrin, proteins integral to iron delivery and myelination, are associated with neurocognitive performance in people with HIV (PWH).	Iron	122-126	transferrin	Homo sapiens	88-99
34315118-1	2021	Trivalent chromium has been proposed to be transported in vivo from the bloodstream to the tissues via endocytosis by transferrin (Tf), the major iron transport protein in the blood.	Iron	146-150	transferrin	Homo sapiens	118-129
34315118-1	2021	Trivalent chromium has been proposed to be transported in vivo from the bloodstream to the tissues via endocytosis by transferrin (Tf), the major iron transport protein in the blood.	Iron	146-150	transferrin	Homo sapiens	131-133
34596670-11	2021	Interpretation of iron studies was least accurate in a scenario of a borderline low ferritin level (40 ng/mL) with low transferrin saturation (2%); 86 participants (26.5%) incorrectly responded that this scenario did not indicate IDA, and 239 (73.5%) correctly identified this scenario as IDA.	Iron	18-22	transferrin	Homo sapiens	119-130
34720016-11	2021	IFNgamma level also correlated with the anti-dsDNA, iron serum, and ferritin levels.	Iron	52-56	interferon gamma	Homo sapiens	0-8
34720016-13	2021	Multivariate regression analysis showed that IFNgamma was positively associated with anti-dsDNA and negatively associated with iron serum and transferrin saturation, while CD8+CD57+ percentages were positively associated with the ferritin levels.	Iron	127-131	interferon gamma	Homo sapiens	45-53
34387792-0	2021	Novel deep intronic mutation in PLA2G6 causing early-onset Parkinson"s disease with brain iron accumulation through pseudo-exon activation.	Iron	90-94	phospholipase A2 group VI	Homo sapiens	32-38
34467981-12	2021	In addition, VA decreased the gene or mRNA expression of aconitase 1 (Aco1; P < 0.001), transferrin receptor (TFRC; P = 0.001), and solute carrier family 11 member 2 (DMT1; P = 0.003) in the Iron Reactive Element/Iron Regulatory Protein (IRE/IRP) signaling pathway although iron and the interaction of VA and iron had no effect on the genes" expression.	Iron	191-195	aconitase 1	Sus scrofa	57-68
34467981-12	2021	In addition, VA decreased the gene or mRNA expression of aconitase 1 (Aco1; P < 0.001), transferrin receptor (TFRC; P = 0.001), and solute carrier family 11 member 2 (DMT1; P = 0.003) in the Iron Reactive Element/Iron Regulatory Protein (IRE/IRP) signaling pathway although iron and the interaction of VA and iron had no effect on the genes" expression.	Iron	191-195	aconitase 1	Sus scrofa	70-74
34467981-12	2021	In addition, VA decreased the gene or mRNA expression of aconitase 1 (Aco1; P < 0.001), transferrin receptor (TFRC; P = 0.001), and solute carrier family 11 member 2 (DMT1; P = 0.003) in the Iron Reactive Element/Iron Regulatory Protein (IRE/IRP) signaling pathway although iron and the interaction of VA and iron had no effect on the genes" expression.	Iron	191-195	transferrin receptor	Sus scrofa	88-108
34467981-12	2021	In addition, VA decreased the gene or mRNA expression of aconitase 1 (Aco1; P < 0.001), transferrin receptor (TFRC; P = 0.001), and solute carrier family 11 member 2 (DMT1; P = 0.003) in the Iron Reactive Element/Iron Regulatory Protein (IRE/IRP) signaling pathway although iron and the interaction of VA and iron had no effect on the genes" expression.	Iron	191-195	transferrin receptor	Sus scrofa	110-114
34339012-8	2021	Knock-down (K-D) parkin flies treated with PQ (1 mM) or PQ (1 mM)/iron (1 mM) significantly diminished the survival index and climbing abilities (e.g., 50% of flies were dead and locomotor impairment by days 4 and 3, respectively).	Iron	66-70	parkin	Drosophila melanogaster	17-23
34339012-11	2021	Similarly, Mel prevented K-D parkin flies against both PQ and PQ/iron.	Iron	65-69	parkin	Drosophila melanogaster	29-35
34685529-0	2021	New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-kappaB Signaling-Mediated Inflammatory Responses in Human Monocytes.	Iron	38-42	nuclear factor kappa B subunit 1	Homo sapiens	67-76
34530349-0	2021	Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis.	Iron	39-43	fibroblast growth factor 21	Homo sapiens	0-27
34530349-4	2021	In the present study, we found that iron overload promoted ferroptosis in hepatocytes by excessively inducing HO-1 expression, which contributed to the progression of liver injury and fibrosis, accompanied by the upregulation of the FGF21 protein level in vitro and in vivo.	Iron	36-40	fibroblast growth factor 21	Homo sapiens	233-238
34530349-5	2021	Interestingly, both recombinant FGF21 and Fgf21 overexpression significantly protected against iron overload-induced hepatocytes mitochondria damage, liver injury and fibrosis by inhibiting ferroptosis.	Iron	95-99	fibroblast growth factor 21	Homo sapiens	32-37
34530349-5	2021	Interestingly, both recombinant FGF21 and Fgf21 overexpression significantly protected against iron overload-induced hepatocytes mitochondria damage, liver injury and fibrosis by inhibiting ferroptosis.	Iron	95-99	fibroblast growth factor 21	Homo sapiens	42-47
34530349-6	2021	In contrast, the loss of FGF21 aggravated iron overload-induced ferroptosis.	Iron	42-46	fibroblast growth factor 21	Homo sapiens	25-30
34530349-9	2021	Thus, FGF21 activation may provide an effective strategy for the potential treatment of iron overload-induced ferroptosis-related diseases, such as hereditary haemochromatosis (HH).	Iron	88-92	fibroblast growth factor 21	Homo sapiens	6-11
34411995-3	2021	Our previous study showed that the crp gene was involved in the regulation of growth rate, biofilm formation, stress tolerance, serum resistance, and iron utilization in G. parasuis.	Iron	150-154	C-reactive protein	Sus scrofa	35-38
34630348-0	2021	The Role of the Moraxella catarrhalis CopB Protein in Facilitating Iron Acquisition From Human Transferrin and Lactoferrin.	Iron	67-71	transferrin	Homo sapiens	95-106
34630348-2	2021	Moraxella catarrhalis resides exclusively on the mucosal surfaces of the upper respiratory tract of humans and is capable of directly acquiring iron for growth from the host glycoproteins human transferrin (hTf) and human lactoferrin (hLf).	Iron	144-148	transferrin	Homo sapiens	194-205
34535254-3	2021	The obtained Fe3O4@MIL-100(Fe) showed satisfactory intrinsic dual enzyme mimetic activities, including peroxidase (POD)- and catalase (CAT)-like activities.	Iron	27-29	catalase	Homo sapiens	135-138
34263950-2	2021	Herein, we present a biocompatible and versatile nanoagent consisting of single-atom iron-containing nanoparticles (SAF NPs), DOX and A549 cell membrane (CM).	Iron	85-89	FAS antisense RNA 1	Homo sapiens	116-119
34579127-0	2021	Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?	Iron	82-86	erythropoietin	Homo sapiens	53-56
34547466-0	2022	Sphingosine-1-phosphate transporter spinster homologue 2 is essential for iron-regulated metastasis of hepatocellular carcinoma.	Iron	74-78	spinster homolog 2	Mus musculus	36-56
34460227-6	2021	The obtained results show that compounds APH1, APH2, APH3, APH4, and APH5 were only able to chelate iron and copper ions among all metals studied and that APH3, APH4, and APH5 were also able to chelate mercury ion.	Iron	100-104	alphaprotein 2	Mus musculus	47-51
34534345-1	2021	BACKGROUND: The non-transferrin bound catalytic iron moiety catalyses production of toxic reactive oxygen species and is associated with adverse outcomes.	Iron	48-52	transferrin	Homo sapiens	20-31
34102366-1	2021	We prepared a single-atom Fe catalyst supported on an oxygen-doped, nitrogen-rich carbon support (SAFe-OCN) for degrading a broad spectrum of contaminants of emerging concern (CECs) by activating peroxides such as peroxymonosulfate (PMS).	Iron	26-28	bone gamma-carboxyglutamate protein	Homo sapiens	103-106
34604659-3	2021	In contrast, NO binding to the ferric center in ((por)Fe(L))+ to give the {FeNO}6 ((por)Fe(NO)(L))+ product results in a shortening of the trans Fe-L bond.	Iron	145-147	cytochrome p450 oxidoreductase	Homo sapiens	50-53
34604659-3	2021	In contrast, NO binding to the ferric center in ((por)Fe(L))+ to give the {FeNO}6 ((por)Fe(NO)(L))+ product results in a shortening of the trans Fe-L bond.	Iron	145-147	cytochrome p450 oxidoreductase	Homo sapiens	84-87
34102366-4	2021	Specifically, SAFe-OCN, with a catalytic center of Fe coordinated with both nitrogen and oxygen (FeNxO4-x), showed 5.13-times increased phenol degradation kinetics upon activating PMS compared to the catalyst where Fe was only coordinated with nitrogen (FeN4).	Iron	51-53	bone gamma-carboxyglutamate protein	Homo sapiens	19-22
34102366-4	2021	Specifically, SAFe-OCN, with a catalytic center of Fe coordinated with both nitrogen and oxygen (FeNxO4-x), showed 5.13-times increased phenol degradation kinetics upon activating PMS compared to the catalyst where Fe was only coordinated with nitrogen (FeN4).	Iron	215-217	bone gamma-carboxyglutamate protein	Homo sapiens	19-22
34520742-2	2022	Here we show that HCV is restricted by an iron-dependent mechanism resembling the one triggering ferroptosis, an iron-dependent form of non-apoptotic cell death, and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2).	Iron	42-46	fatty acid desaturase 2	Homo sapiens	276-299
34575794-9	2021	Taken together, these results suggest that nitrogen starvation downregulates the high-affinity iron uptake system by degrading Mac1 in a proteasome-dependent manner and eventually downregulates copper metabolism.	Iron	95-99	Mac1p	Saccharomyces cerevisiae S288C	127-131
34589492-0	2021	Nrf2 Is a Potential Modulator for Orchestrating Iron Homeostasis and Redox Balance in Cancer Cells.	Iron	48-52	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34589492-9	2021	Recently, several genes involving cellular iron homeostasis are identified under the control of Nrf2.	Iron	43-47	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
34589492-10	2021	Since cancer cells require amounts of iron and Nrf2 plays pivotal roles in oxidative defense and iron metabolism, it is highly probable that Nrf2 is a potential modulator orchestrating iron homeostasis and redox balance in cancer cells.	Iron	38-42	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
34589492-10	2021	Since cancer cells require amounts of iron and Nrf2 plays pivotal roles in oxidative defense and iron metabolism, it is highly probable that Nrf2 is a potential modulator orchestrating iron homeostasis and redox balance in cancer cells.	Iron	97-101	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
34589492-10	2021	Since cancer cells require amounts of iron and Nrf2 plays pivotal roles in oxidative defense and iron metabolism, it is highly probable that Nrf2 is a potential modulator orchestrating iron homeostasis and redox balance in cancer cells.	Iron	97-101	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
34589492-10	2021	Since cancer cells require amounts of iron and Nrf2 plays pivotal roles in oxidative defense and iron metabolism, it is highly probable that Nrf2 is a potential modulator orchestrating iron homeostasis and redox balance in cancer cells.	Iron	185-189	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
34589492-10	2021	Since cancer cells require amounts of iron and Nrf2 plays pivotal roles in oxidative defense and iron metabolism, it is highly probable that Nrf2 is a potential modulator orchestrating iron homeostasis and redox balance in cancer cells.	Iron	185-189	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
34589492-11	2021	In this hypothesis, we summarize the recent findings of the role of iron and Nrf2 in cancer cells and demonstrate how Nrf2 balances the oxidative stress induced by iron through regulating antioxidant enzymes and iron metabolism.	Iron	68-72	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
34589492-11	2021	In this hypothesis, we summarize the recent findings of the role of iron and Nrf2 in cancer cells and demonstrate how Nrf2 balances the oxidative stress induced by iron through regulating antioxidant enzymes and iron metabolism.	Iron	164-168	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
34589492-11	2021	In this hypothesis, we summarize the recent findings of the role of iron and Nrf2 in cancer cells and demonstrate how Nrf2 balances the oxidative stress induced by iron through regulating antioxidant enzymes and iron metabolism.	Iron	164-168	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
34589492-11	2021	In this hypothesis, we summarize the recent findings of the role of iron and Nrf2 in cancer cells and demonstrate how Nrf2 balances the oxidative stress induced by iron through regulating antioxidant enzymes and iron metabolism.	Iron	212-216	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
34589492-11	2021	In this hypothesis, we summarize the recent findings of the role of iron and Nrf2 in cancer cells and demonstrate how Nrf2 balances the oxidative stress induced by iron through regulating antioxidant enzymes and iron metabolism.	Iron	212-216	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
34589492-13	2021	Since ferroptosis is dependent on lipid peroxide and iron accumulation, Nrf2 inhibition may dramatically increase sensitivity to ferroptosis.	Iron	53-57	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
34646383-10	2021	The deletion of PDK1 in Treg cells destroyed the iron ion balance through regulating MEK-ERK signaling and CD71 expression, resulting in excessive production of intracellular ROS, which did not depend on the down-regulation of mTORC1 signaling.	Iron	49-53	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	16-20
34646383-10	2021	The deletion of PDK1 in Treg cells destroyed the iron ion balance through regulating MEK-ERK signaling and CD71 expression, resulting in excessive production of intracellular ROS, which did not depend on the down-regulation of mTORC1 signaling.	Iron	49-53	mitogen-activated protein kinase 1	Mus musculus	89-92
34520742-2	2022	Here we show that HCV is restricted by an iron-dependent mechanism resembling the one triggering ferroptosis, an iron-dependent form of non-apoptotic cell death, and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2).	Iron	42-46	fatty acid desaturase 2	Homo sapiens	301-306
34382981-3	2021	The aliphatic H-atom abstraction (HAA) vs. electrophilic aromatic substitution (EAS) steps are responsible for the sp3 vs. sp2 C-H amination site-selectivity and a larger steric congestion disfavors sp2 EAS, thus resulting in Fe-catalyzed site-selectivity toward sp3 C-H amination.	Iron	226-228	Sp3 transcription factor	Homo sapiens	115-118
34382981-3	2021	The aliphatic H-atom abstraction (HAA) vs. electrophilic aromatic substitution (EAS) steps are responsible for the sp3 vs. sp2 C-H amination site-selectivity and a larger steric congestion disfavors sp2 EAS, thus resulting in Fe-catalyzed site-selectivity toward sp3 C-H amination.	Iron	226-228	Sp2 transcription factor	Homo sapiens	123-126
34382981-3	2021	The aliphatic H-atom abstraction (HAA) vs. electrophilic aromatic substitution (EAS) steps are responsible for the sp3 vs. sp2 C-H amination site-selectivity and a larger steric congestion disfavors sp2 EAS, thus resulting in Fe-catalyzed site-selectivity toward sp3 C-H amination.	Iron	226-228	Sp2 transcription factor	Homo sapiens	199-202
34382981-3	2021	The aliphatic H-atom abstraction (HAA) vs. electrophilic aromatic substitution (EAS) steps are responsible for the sp3 vs. sp2 C-H amination site-selectivity and a larger steric congestion disfavors sp2 EAS, thus resulting in Fe-catalyzed site-selectivity toward sp3 C-H amination.	Iron	226-228	Sp3 transcription factor	Homo sapiens	263-266
34229395-2	2021	Compared with zero-valent iron-loaded biochar (C-nZVI-BC) prepared by the traditional chemical liquid phase synthesis method, G-nZVI-BC containing tea polyphenols further improved dispersibility of Fe0 on biochar, prevented nZVI agglomeration on BC, and promoted PNP degradation.	Iron	26-30	purine nucleoside phosphorylase	Homo sapiens	263-266
34493724-3	2021	The expression of two iron metabolic genes (FPN and LCN2) was selectively knocked down in cancer cells by Cas13a or microRNA controlled by a NF-kappaB-specific promoter.	Iron	22-26	nuclear factor kappa B subunit 1	Homo sapiens	141-150
34216828-6	2021	Rhizosphere acidification-triggered STOP1 accumulation activates excretion of organic acids, which help solubilize Pi from insoluble iron or calcium phosphates.	Iron	133-137	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	36-41
34502536-4	2021	Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner.	Iron	61-65	tumor protein p53	Homo sapiens	104-107
34502536-4	2021	Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner.	Iron	61-65	BCL2 associated X, apoptosis regulator	Homo sapiens	392-395
34502536-4	2021	Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner.	Iron	61-65	tumor protein p53	Homo sapiens	401-404
34236433-9	2021	However, cord hepcidin and the hepcidin:erythropoietin (EPO) ratio captured the most variance in newborn iron and hematologic status (>25% of variance explained).	Iron	105-109	erythropoietin	Homo sapiens	40-54
34236433-9	2021	However, cord hepcidin and the hepcidin:erythropoietin (EPO) ratio captured the most variance in newborn iron and hematologic status (>25% of variance explained).	Iron	105-109	erythropoietin	Homo sapiens	56-59
34339740-3	2021	Recently, BACH1 (BTB and CNC homology 1), a heme-regulated transcription factor that represses genes involved in iron- and heme-metabolism in normal cells, was shown to shape the metabolism and metastatic potential of cancer cells.	Iron	113-117	BTB domain and CNC homolog 1	Homo sapiens	10-15
34302445-2	2021	Here, the authors report a facile approach to independently regulate the electronic structure of Fe in Ni0.75 Fe0.25 Se2 by P doping.	Iron	97-99	fucosyltransferase 2	Homo sapiens	117-120
34338042-1	2021	Tissue iron overload is associated with insulin resistance and mitochondrial dysfunction in rodents and humans; however, the mechanisms or cell types that mediate this phenotype are not completely understood.	Iron	7-11	insulin	Homo sapiens	40-47
34338042-2	2021	Macrophages (Mphi)s are known to contribute to iron handling; thus, we hypothesized that perturbed iron handling by Mphis impairs mitochondrial energetics and evokes systemic insulin resistance in mice.	Iron	47-51	insulin	Homo sapiens	175-182
34338042-2	2021	Macrophages (Mphi)s are known to contribute to iron handling; thus, we hypothesized that perturbed iron handling by Mphis impairs mitochondrial energetics and evokes systemic insulin resistance in mice.	Iron	99-103	insulin	Homo sapiens	175-182
34338042-9	2021	These findings also suggest that if Mphis are capable of storing iron properly, they have a pronounced ability to withstand iron excess without evoking overt collateral damage and associated insulin resistance that may be age dependent.	Iron	65-69	insulin	Homo sapiens	191-198
34734006-9	2021	Moreover, silencing of ACSL4 could abrogate sev-induced cell damage, as evidenced by increases in cell viability, GPX4 protein levels, and decreases in iron levels, ROS production, and MDA and 4-HNE content.	Iron	152-156	acyl-CoA synthetase long chain family member 4	Homo sapiens	23-28
34480710-8	2022	The decreased levels of TfR1 and the upregulation of FPN1 and FTH proteins observed in the LIRA-treated db/db group were shown to reduce iron overload in the hippocampus, whereas the increased expression of Mtft and decreased expression of Mfrn in the mitochondria indicated that mitochondrial iron overload was ameliorated.	Iron	137-141	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	53-57
34480710-8	2022	The decreased levels of TfR1 and the upregulation of FPN1 and FTH proteins observed in the LIRA-treated db/db group were shown to reduce iron overload in the hippocampus, whereas the increased expression of Mtft and decreased expression of Mfrn in the mitochondria indicated that mitochondrial iron overload was ameliorated.	Iron	294-298	solute carrier family 25, member 37	Mus musculus	240-244
34287090-4	2021	We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron.	Iron	117-121	peroxisome proliferator activated receptor alpha	Mus musculus	26-74
34287090-4	2021	We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron.	Iron	117-121	peroxisome proliferator activated receptor alpha	Mus musculus	76-85
34287090-4	2021	We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron.	Iron	191-195	peroxisome proliferator activated receptor alpha	Mus musculus	26-74
34287090-4	2021	We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron.	Iron	191-195	peroxisome proliferator activated receptor alpha	Mus musculus	76-85
34287090-7	2021	In-vitro and in-vivo iron treatment resulted in the downregulation of PPARalpha, Sirt3, active beta-catenin and its downstream target gene c-Myc in the mouse liver.	Iron	21-25	peroxisome proliferator activated receptor alpha	Mus musculus	70-79
34287090-8	2021	Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression.	Iron	210-214	actin alpha 2, smooth muscle, aorta	Mus musculus	239-247
34287090-10	2021	In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis.	Iron	26-30	peroxisome proliferator activated receptor alpha	Mus musculus	50-59
34287090-10	2021	In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis.	Iron	96-100	peroxisome proliferator activated receptor alpha	Mus musculus	50-59
34287090-10	2021	In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis.	Iron	128-132	peroxisome proliferator activated receptor alpha	Mus musculus	50-59
34287090-11	2021	Thus, our results establish a novel link between hepatic iron and PPARalpha, Sirt3 and beta-catenin signaling.	Iron	57-61	peroxisome proliferator activated receptor alpha	Mus musculus	66-75
34298093-7	2021	Heme-iron induced lipid peroxidation and DNA oxidation by interacting with Nox4-independent mechanisms, promoting p53/p21 activity and cellular senescence.	Iron	5-9	tumor protein p53	Homo sapiens	114-117
34126280-0	2021	A unique case of skeletal dysplasia in an adult male in Late Iron Age Switzerland.	Iron	61-65	renin binding protein	Homo sapiens	66-69
34126280-1	2021	OBJECTIVE: We report a probable case of multiple skeletal dysplasia observed in a Late Iron Age young adult male.	Iron	87-91	renin binding protein	Homo sapiens	92-95
34126280-2	2021	MATERIALS: The individual studied belongs to a Late Iron Age necropolis from Switzerland.	Iron	52-56	renin binding protein	Homo sapiens	57-60
34339740-3	2021	Recently, BACH1 (BTB and CNC homology 1), a heme-regulated transcription factor that represses genes involved in iron- and heme-metabolism in normal cells, was shown to shape the metabolism and metastatic potential of cancer cells.	Iron	113-117	BTB domain and CNC homolog 1	Homo sapiens	17-39
34339740-4	2021	The growing list of BACH1 target genes in cancer cells reveals that BACH1 promotes metastasis by regulating various sets of genes beyond iron metabolism.	Iron	137-141	BTB domain and CNC homolog 1	Homo sapiens	68-73
34339740-8	2021	We discuss here the possibility that BACH1-mediated promotion of cancer also brings increased sensitivity to iron-dependent cell death (ferroptosis) through crosstalk of BACH1 target genes, imposing programmed vulnerability upon cancer cells.	Iron	109-113	BTB domain and CNC homolog 1	Homo sapiens	37-42
34217587-13	2021	CONCLUSION: Elevated levels of serum ferritin and hepcidin in newly diagnosed diabetics (but not pre-diabetics) indicate dysregulated iron homeostasis, with the former positively associated with insulin resistance in these patients.	Iron	134-138	insulin	Homo sapiens	195-202
34080200-4	2021	-We have searched for ascorbate membrane transporters responsible for controlling Fe reduction through a screening in the yeast ferric reductase-deficient fre1 strain and have isolated AtDTX25, a member of the Multidrug And Toxic compound Extrusion (MATE) family.	Iron	82-84	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	155-159
34415263-9	2021	No relationship was noted between serum ferritin and iron absorption but transferrin saturation (54%), MCV (7%), and hematocrit (6%) accounted for 67% of the variation in iron absorption (P < 0.001).	Iron	171-175	transferrin	Homo sapiens	73-84
34427071-11	2021	Furthermore, we found that ROS levels and DMT1 expression were elevated in TG905 cells treated with temozolomide and were accompanied by a decrease in the expression of glutathione peroxidase 4, indicating an iron-dependent cell death, ferroptosis.	Iron	209-213	charged multivesicular body protein 2B	Homo sapiens	42-46
34476177-13	2021	Age-related changes of iron content are different in the pulvinar and the rest of the thalamus as well as in internal and external globus pallidus.	Iron	23-27	renin binding protein	Homo sapiens	0-3
34527177-0	2021	Erratum to "Sex-Specific Negative Association between Iron Intake and Cellular Aging Markers: Mediation Models Involving TNFalpha".	Iron	54-58	tumor necrosis factor	Homo sapiens	121-129
34573347-1	2021	Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2.	Iron	0-4	iron responsive element binding protein 2	Homo sapiens	130-134
34573347-1	2021	Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2.	Iron	96-100	iron responsive element binding protein 2	Homo sapiens	130-134
34462321-5	2021	We also uncovered a paralogous synthetic lethal mechanism behind a genetic interaction between STAG2 and the iron regulatory gene IREB2 Finally, investigation of an unusually strong context-dependent genetic interaction in HAP1 cells revealed factors that could be important for alleviating cohesin loading stress.	Iron	109-113	iron responsive element binding protein 2	Homo sapiens	130-135
34292737-0	2021	Fusaricide is a Novel Iron Chelator that Induces Apoptosis through Activating Caspase-3.	Iron	22-26	caspase 3	Homo sapiens	78-87
34577568-5	2021	Lactoferrin is an iron-binding, anti-inflammatory glycoprotein that displays analgesic activities associated, in part, by interacting with the low-density lipoprotein receptor-related protein (LRP), which may result in the regulation of the DAMP-TRAF6-NFkappaB, NO-cGMP-ATP K+-sensitive channel and opioid receptor signaling pathways.	Iron	18-22	LDL receptor related protein 1	Homo sapiens	193-196
34402883-7	2021	Using the MLL-AF9 mouse model of AML, we demonstrated that the AML-induced loss of erythroblasts is responsible for iron redistribution and increased TSAT.	Iron	116-120	lysine (K)-specific methyltransferase 2A	Mus musculus	10-13
34707440-1	2021	Gram-negative bacterium Neisseria meningitidis, responsible for human infectious disease meningitis, acquires the iron (Fe3+) ion needed for its survival from human transferrin protein (hTf).	Iron	114-118	transferrin	Homo sapiens	165-176
34218987-8	2021	Similarly, FE induced a significant rise in TNFalpha, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05).	Iron	11-13	tumor necrosis factor	Homo sapiens	44-52
34218987-8	2021	Similarly, FE induced a significant rise in TNFalpha, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05).	Iron	11-13	fibrinogen beta chain	Homo sapiens	58-68
34426578-5	2021	Cellular studies indicate that both Dpep1 and Chmp1a are important regulators of a single pathway, ferroptosis and lead to kidney disease development via altering cellular iron trafficking.	Iron	172-176	charged multivesicular body protein 1A	Mus musculus	46-52
34429458-6	2021	Reduced levels of PGC1beta resulted in deregulated expression of iron, heme and globin related genes in polychromatic erythroblasts, and reduced hemoglobin content in the more mature bone marrow derived reticulocytes.	Iron	65-69	PPARG coactivator 1 alpha	Homo sapiens	18-26
34417961-11	2021	TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 x 10-6).	Iron	80-82	tumor associated calcium signal transducer 2	Homo sapiens	0-7
34417961-11	2021	TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 x 10-6).	Iron	80-82	LDL receptor related protein 1B	Homo sapiens	15-20
34242792-5	2021	Additionally, IDO1 deficiency prevented against APAP-induced liver injury through suppressing the activation of macrophages, thereby reduced their iron uptake and export, eventually reduced iron accumulation in hepatocytes through transferrin and transferrin receptor axis.	Iron	190-194	transferrin	Homo sapiens	231-242
34447779-0	2021	Certain Associations Between Iron Biomarkers and Total and gamma" Fibrinogen and Plasma Clot Properties Are Mediated by Fibrinogen Genotypes.	Iron	29-33	fibrinogen beta chain	Homo sapiens	120-130
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	184-188	mitogen-activated protein kinase 1	Mus musculus	247-250
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	184-188	thymoma viral proto-oncogene 1	Mus musculus	252-255
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	184-188	signal transducer and activator of transcription 3	Mus musculus	261-266
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	346-350	mitogen-activated protein kinase 1	Mus musculus	247-250
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	346-350	thymoma viral proto-oncogene 1	Mus musculus	252-255
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	346-350	signal transducer and activator of transcription 3	Mus musculus	261-266
34389031-12	2021	Further experiments showed that TFRC, the primary receptor for transferrin-mediated iron uptake, was overexpressed on HCC cells but not TAM.	Iron	84-88	transferrin	Homo sapiens	63-74
34389031-13	2021	Mechanistically, HCC cells competed with macrophages for iron to upregulate the expression of M2-related genes via induction of HIF-1alpha, thus contributing to M2-like TAM polarization.	Iron	57-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
34144137-3	2021	Herein, an intraerythrocytic parasite targeted nanostructured lipid carrier (NLC) was developed for potentiation of artemether (ARM) by combination with PPIX and iron-loaded transferrin (holo-Tf).	Iron	162-166	transferrin	Homo sapiens	174-185
34429676-5	2021	Iron overload was represented by serum ferritin (FS) and transferrin saturation (TS), while the endocrine function was examined by the Thyroid Stimulating Hormone-sensitive (TSHs), free T4 (fT4), and insulin-like growth factor-1 (IGF-1).	Iron	0-4	transferrin	Homo sapiens	57-68
34429676-11	2021	Conclusion: Based on serum ferritin, iron overload is discovered to have a negative correlation with free T4 and insulin-like growth factor-1.	Iron	37-41	insulin like growth factor 1	Homo sapiens	113-141
34388243-2	2022	Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which consequently drives cardiomyopathy through ferroptosis, an iron-dependent non-apoptotic form of cell death.	Iron	162-166	heme oxygenase 1	Mus musculus	72-88
34388243-2	2022	Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which consequently drives cardiomyopathy through ferroptosis, an iron-dependent non-apoptotic form of cell death.	Iron	162-166	heme oxygenase 1	Mus musculus	90-95
34388243-5	2022	Since free iron, a product of heme degradation through Hmox1, has been implicated in toxicities including ferroptosis, we evaluated the downstream effects of elevated heme in SCD.	Iron	11-15	heme oxygenase 1	Mus musculus	55-60
34439518-7	2021	DFO (40-60 mg/Kg/day) reduced the iron saturation of blood transferrin.	Iron	34-38	transferrin	Homo sapiens	59-70
34447779-16	2021	Conclusion: This is the first large-scale epidemiological study to relate fibrinogen concentration and functionality to markers of iron status and to take genetic factors into consideration.	Iron	131-135	fibrinogen beta chain	Homo sapiens	74-84
34447779-17	2021	We have detected a relationship between iron biomarkers and fibrinogen as well as clot characteristics that are influenced by the genetic make-up of an individual.	Iron	40-44	fibrinogen beta chain	Homo sapiens	60-70
34174197-6	2021	Specific reduction of adipocyte iron by AAV-mediated overexpression of the iron exporter Ferroportin1 in adult mice effectively mimics these protective effects.	Iron	32-36	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	89-101
34434890-5	2021	Our data demonstrated that the silencing of circFNDC3B by shRNA inhibited GPX4 and SLC7A11 expression and enhanced ROS, iron, and Fe2+ levels in OSCC cells.	Iron	120-124	fibronectin type III domain containing 3B	Mus musculus	44-54
34351131-3	2021	However, the contributions of Fe(V)/Fe(IV) accounted for over 50% during the oxidation of sulfamethoxazole, bisphenol S, and iohexol by Fe(VI), and the variation trends of kapp of their degradation by Fe(VI) with time displayed three different patterns, which coincided with those of the contributions of Fe(V)/Fe(IV) to their decomposition with time.	Iron	136-138	FEV transcription factor, ETS family member	Homo sapiens	30-35
34351131-3	2021	However, the contributions of Fe(V)/Fe(IV) accounted for over 50% during the oxidation of sulfamethoxazole, bisphenol S, and iohexol by Fe(VI), and the variation trends of kapp of their degradation by Fe(VI) with time displayed three different patterns, which coincided with those of the contributions of Fe(V)/Fe(IV) to their decomposition with time.	Iron	136-138	FEV transcription factor, ETS family member	Homo sapiens	305-310
34351131-3	2021	However, the contributions of Fe(V)/Fe(IV) accounted for over 50% during the oxidation of sulfamethoxazole, bisphenol S, and iohexol by Fe(VI), and the variation trends of kapp of their degradation by Fe(VI) with time displayed three different patterns, which coincided with those of the contributions of Fe(V)/Fe(IV) to their decomposition with time.	Iron	201-203	FEV transcription factor, ETS family member	Homo sapiens	30-35
34351131-3	2021	However, the contributions of Fe(V)/Fe(IV) accounted for over 50% during the oxidation of sulfamethoxazole, bisphenol S, and iohexol by Fe(VI), and the variation trends of kapp of their degradation by Fe(VI) with time displayed three different patterns, which coincided with those of the contributions of Fe(V)/Fe(IV) to their decomposition with time.	Iron	201-203	FEV transcription factor, ETS family member	Homo sapiens	305-310
34351131-3	2021	However, the contributions of Fe(V)/Fe(IV) accounted for over 50% during the oxidation of sulfamethoxazole, bisphenol S, and iohexol by Fe(VI), and the variation trends of kapp of their degradation by Fe(VI) with time displayed three different patterns, which coincided with those of the contributions of Fe(V)/Fe(IV) to their decomposition with time.	Iron	311-313	FEV transcription factor, ETS family member	Homo sapiens	30-35
34351131-3	2021	However, the contributions of Fe(V)/Fe(IV) accounted for over 50% during the oxidation of sulfamethoxazole, bisphenol S, and iohexol by Fe(VI), and the variation trends of kapp of their degradation by Fe(VI) with time displayed three different patterns, which coincided with those of the contributions of Fe(V)/Fe(IV) to their decomposition with time.	Iron	311-313	FEV transcription factor, ETS family member	Homo sapiens	305-310
34351131-4	2021	Results of the quenching experiments were validated by simulating the oxidation kinetic data of methyl phenyl sulfoxide by Fe(VI), which revealed that the variation trends of kapp with time were significantly determined by the change in the molar ratio of Fe(V) to Fe(VI) with time, highlighting the key role of Fe(V) in the oxidative process.	Iron	123-125	FEV transcription factor, ETS family member	Homo sapiens	256-261
34351131-4	2021	Results of the quenching experiments were validated by simulating the oxidation kinetic data of methyl phenyl sulfoxide by Fe(VI), which revealed that the variation trends of kapp with time were significantly determined by the change in the molar ratio of Fe(V) to Fe(VI) with time, highlighting the key role of Fe(V) in the oxidative process.	Iron	123-125	FEV transcription factor, ETS family member	Homo sapiens	312-317
34351131-4	2021	Results of the quenching experiments were validated by simulating the oxidation kinetic data of methyl phenyl sulfoxide by Fe(VI), which revealed that the variation trends of kapp with time were significantly determined by the change in the molar ratio of Fe(V) to Fe(VI) with time, highlighting the key role of Fe(V) in the oxidative process.	Iron	265-267	FEV transcription factor, ETS family member	Homo sapiens	256-261
34351131-4	2021	Results of the quenching experiments were validated by simulating the oxidation kinetic data of methyl phenyl sulfoxide by Fe(VI), which revealed that the variation trends of kapp with time were significantly determined by the change in the molar ratio of Fe(V) to Fe(VI) with time, highlighting the key role of Fe(V) in the oxidative process.	Iron	265-267	FEV transcription factor, ETS family member	Homo sapiens	312-317
34351131-5	2021	This study provides comprehensive and insightful information on the roles of Fe(V)/Fe(IV) during EOC oxidation by Fe(VI).	Iron	114-116	FEV transcription factor, ETS family member	Homo sapiens	77-82
34394834-6	2021	During CIH exposure, the shHamp mice showed a lower level of total iron and neuronal iron in the hippocampus, via stabilizing ferroportin 1 (FPN1) and decreasing L-ferritin (FTL) levels, when compared with wild-type (WT) mice.	Iron	85-89	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	126-139
34394834-6	2021	During CIH exposure, the shHamp mice showed a lower level of total iron and neuronal iron in the hippocampus, via stabilizing ferroportin 1 (FPN1) and decreasing L-ferritin (FTL) levels, when compared with wild-type (WT) mice.	Iron	85-89	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	141-145
34394834-9	2021	Therefore, our data revealed that highly expressed hepcidin might promote the degradation of FPN1, resulting in neuronal iron deposition, oxidative stress damage, reduced synaptic plasticity, and impaired cognitive performance during CIH exposure.	Iron	121-125	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	93-97
34085413-5	2021	We found a protective effect of catalase against the inactivation of CYP2E1 heme by H 2 O 2 and the direct transfer of photo-induced electrons to the heme iron not by peroxide shunt.	Iron	155-159	catalase	Homo sapiens	32-40
34351131-2	2021	Employing excess caffeine as the quenching reagent for Fe(V) and Fe(IV), it was found that Fe(V)/Fe(IV) contributed to 20-30% of phenol and bisphenol F degradation by Fe(VI), and the contributions of Fe(V)/Fe(IV) remained nearly constant with time under all the tested conditions.	Iron	97-99	FEV transcription factor, ETS family member	Homo sapiens	55-60
34351131-2	2021	Employing excess caffeine as the quenching reagent for Fe(V) and Fe(IV), it was found that Fe(V)/Fe(IV) contributed to 20-30% of phenol and bisphenol F degradation by Fe(VI), and the contributions of Fe(V)/Fe(IV) remained nearly constant with time under all the tested conditions.	Iron	97-99	FEV transcription factor, ETS family member	Homo sapiens	91-96
34351131-2	2021	Employing excess caffeine as the quenching reagent for Fe(V) and Fe(IV), it was found that Fe(V)/Fe(IV) contributed to 20-30% of phenol and bisphenol F degradation by Fe(VI), and the contributions of Fe(V)/Fe(IV) remained nearly constant with time under all the tested conditions.	Iron	167-169	FEV transcription factor, ETS family member	Homo sapiens	55-60
34351131-2	2021	Employing excess caffeine as the quenching reagent for Fe(V) and Fe(IV), it was found that Fe(V)/Fe(IV) contributed to 20-30% of phenol and bisphenol F degradation by Fe(VI), and the contributions of Fe(V)/Fe(IV) remained nearly constant with time under all the tested conditions.	Iron	167-169	FEV transcription factor, ETS family member	Homo sapiens	91-96
34174197-6	2021	Specific reduction of adipocyte iron by AAV-mediated overexpression of the iron exporter Ferroportin1 in adult mice effectively mimics these protective effects.	Iron	75-79	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	89-101
34148259-13	2021	Iron overload led to liver iron deposition, fibrosis and increased serum alanine aminotransferase and aspartate aminotransferase.	Iron	0-4	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	102-128
34254256-0	2021	The Impact of Intravenous Iron Supplementation on Hematinic Parameters and Erythropoietin Requirements in Hemodialysis Patients.	Iron	26-30	erythropoietin	Homo sapiens	75-89
34254256-2	2021	As a result of the side effects of high doses of recombinant human erythropoietin (rhEPO) and the differences in the standard dose of the injectable iron, this study aimed to evaluate the effect of high and low intravenous iron supplementation on hematinic parameters and EPO requirements in patients under hemodialysis.	Iron	149-153	erythropoietin	Homo sapiens	272-275
34254256-7	2021	Transferrin saturation (TSAT) index had a significant upward trend after iron injection and significant correlations with the serum levels of Fe (r >= 0.353, P <= 0.007), ferritin (r >= 0.315, P <= 0.016), and total iron binding capacity (r >= 0.219, P < 0.050) during the follow-up period in the studied groups.	Iron	73-77	transferrin	Homo sapiens	0-11
34254256-7	2021	Transferrin saturation (TSAT) index had a significant upward trend after iron injection and significant correlations with the serum levels of Fe (r >= 0.353, P <= 0.007), ferritin (r >= 0.315, P <= 0.016), and total iron binding capacity (r >= 0.219, P < 0.050) during the follow-up period in the studied groups.	Iron	142-144	transferrin	Homo sapiens	0-11
34254256-7	2021	Transferrin saturation (TSAT) index had a significant upward trend after iron injection and significant correlations with the serum levels of Fe (r >= 0.353, P <= 0.007), ferritin (r >= 0.315, P <= 0.016), and total iron binding capacity (r >= 0.219, P < 0.050) during the follow-up period in the studied groups.	Iron	216-220	transferrin	Homo sapiens	0-11
34119884-7	2021	In addition, the blockage of bypassing EGFR/AKT/NF-kB/IkB signaling pathway is greatly enhanced via elevated intracellular PMA/Fe-HSA@DOX nanoparticles (NPs).	Iron	127-129	epidermal growth factor receptor	Homo sapiens	39-43
34119884-7	2021	In addition, the blockage of bypassing EGFR/AKT/NF-kB/IkB signaling pathway is greatly enhanced via elevated intracellular PMA/Fe-HSA@DOX nanoparticles (NPs).	Iron	127-129	AKT serine/threonine kinase 1	Homo sapiens	44-47
34361070-8	2021	Furthermore, miR-7-5p knockdown results in the down-regulation of the iron storage gene expression such as ferritin, up-regulation of the ferroptosis marker ALOX12 gene expression, and increases of Liperfluo amount.	Iron	70-74	microRNA 7-2	Homo sapiens	13-21
34160288-0	2021	Effects of altitude and recombinant human erythropoietin on iron metabolism: a randomized controlled trial.	Iron	60-64	erythropoietin	Homo sapiens	42-56
34360999-3	2021	CYP2E1 is a unique P450 enzyme because its heme iron is constitutively in the high spin state, allowing direct reduction of, e.g., dioxygen, causing the formation of a variety of reactive oxygen species and reduction of xenobiotics to toxic products.	Iron	48-52	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
34219295-8	2021	Our results suggest a causative association between TDP-43 and iron accumulation in the pathomechanisms of ALS presenting with upper motor neuron signs.	Iron	63-67	TAR DNA binding protein	Homo sapiens	52-58
34330792-2	2021	The CARENFER study aimed to assess the prevalence of ID using both serum ferritin concentration and transferrin coefficient saturation (iron-saturation of transferrin, TSAT) index, as well as ID anaemia in patients with cancer.	Iron	136-140	transferrin	Homo sapiens	100-111
34330792-2	2021	The CARENFER study aimed to assess the prevalence of ID using both serum ferritin concentration and transferrin coefficient saturation (iron-saturation of transferrin, TSAT) index, as well as ID anaemia in patients with cancer.	Iron	136-140	transferrin	Homo sapiens	155-166
34820583-5	2022	POD-like activity was mainly attributed to MoS2 NSs, while CAT-like activity was primarily due to TA/Fe complex.	Iron	101-103	catalase	Homo sapiens	59-62
34362147-12	2021	We propose that this correlation may be related to increased hematopoietic stress, increased consumption of nitric oxide (NO) by hemolysis, and the inhibitory effects of iron supplements on osteogenesis through the receptor activator of nuclear factor kappaB ligand (RANKL)/Osteoprotegerin pathway and the Runt-related transcription factor 2 (RUNX2) factor.	Iron	170-174	RUNX family transcription factor 2	Homo sapiens	306-341
34362147-12	2021	We propose that this correlation may be related to increased hematopoietic stress, increased consumption of nitric oxide (NO) by hemolysis, and the inhibitory effects of iron supplements on osteogenesis through the receptor activator of nuclear factor kappaB ligand (RANKL)/Osteoprotegerin pathway and the Runt-related transcription factor 2 (RUNX2) factor.	Iron	170-174	RUNX family transcription factor 2	Homo sapiens	343-348
34440102-4	2021	The results of numerous studies indicate that diet supplementation with lactoferrin (LTF), an iron-binding protein, may be advantageous in prophylaxis and treatment of iron deficiency anemia.	Iron	94-98	lactotransferrin	Homo sapiens	72-83
34440102-4	2021	The results of numerous studies indicate that diet supplementation with lactoferrin (LTF), an iron-binding protein, may be advantageous in prophylaxis and treatment of iron deficiency anemia.	Iron	94-98	lactotransferrin	Homo sapiens	85-88
34440102-5	2021	LTF, administered orally, normalizes iron homeostasis, not only by facilitating iron absorption, but also by inhibiting inflammatory processes responsible for anemia of chronic diseases, characterized by a functional iron deficit for physiological processes.	Iron	37-41	lactotransferrin	Homo sapiens	0-3
34440102-5	2021	LTF, administered orally, normalizes iron homeostasis, not only by facilitating iron absorption, but also by inhibiting inflammatory processes responsible for anemia of chronic diseases, characterized by a functional iron deficit for physiological processes.	Iron	80-84	lactotransferrin	Homo sapiens	0-3
34440102-5	2021	LTF, administered orally, normalizes iron homeostasis, not only by facilitating iron absorption, but also by inhibiting inflammatory processes responsible for anemia of chronic diseases, characterized by a functional iron deficit for physiological processes.	Iron	217-221	lactotransferrin	Homo sapiens	0-3
34444799-5	2021	Various interventions can lower the oxidant load in PN, including the supplementation of PN with antioxidant vitamins, glutathione, additional arginine and additional cysteine; reduced levels of pro-oxidant nutrients such as iron; protection from light and oxygen; and proper storage temperature.	Iron	225-229	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	52-54
34395447-0	2021	The p53 Family: A Role in Lipid and Iron Metabolism.	Iron	36-40	tumor protein p53	Homo sapiens	4-7
34395447-3	2021	In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism.	Iron	117-121	tumor protein p53	Homo sapiens	86-89
34315867-6	2021	Here, we demonstrated that deletion of TRIB2 sensitized ferroptosis via lifting labile iron in liver cancer cells.	Iron	87-91	tribbles pseudokinase 2	Homo sapiens	39-44
34315867-13	2021	In conclusion, we elucidated a novel role of TRIB2 to desensitize ferroptosis via E3 betaTrCP, by which facilitates TFRC ubiquitiation and finally decreases labile iron in liver cancer cells.	Iron	164-168	tribbles pseudokinase 2	Homo sapiens	45-50
34290391-11	2021	This study demonstrates that FSS acts through iron to induce pro-arteriogenic PLGF, suggesting iron supplementation as a novel potential treatment for revascularization.	Iron	46-50	placental growth factor	Homo sapiens	78-82
34439408-4	2021	Importantly, we found that a combined treatment with the cell permeant iron chelator deferiprone and the glutathione precursor N-acetyl cysteine promoted the structural repair of mitochondria and ER, decreased mitochondrial labile iron and ROS levels, and restored glucose-stimulated insulin secretion.	Iron	71-75	insulin	Homo sapiens	284-291
34290391-11	2021	This study demonstrates that FSS acts through iron to induce pro-arteriogenic PLGF, suggesting iron supplementation as a novel potential treatment for revascularization.	Iron	95-99	placental growth factor	Homo sapiens	78-82
34290391-0	2021	Fluid shear stress regulates placental growth factor expression via heme oxygenase 1 and iron.	Iron	89-93	placental growth factor	Homo sapiens	29-52
34236052-4	2021	Mice lacking FTH in the myeloid lineage (LysM-Cre+/+Fthfl/fl mice) displayed impaired iron storage capacities in the tissue leukocyte compartment, increased levels of labile iron in macrophages, and an accelerated macrophage-mediated iron turnover.	Iron	86-90	lysozyme 2	Mus musculus	41-45
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Iron	186-190	heme oxygenase 1	Mus musculus	60-76
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Iron	186-190	heme oxygenase 1	Mus musculus	78-82
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Iron	186-190	heme oxygenase 1	Mus musculus	84-89
34300354-2	2021	Liver iron accumulation is also related to hyperferritinemia, insulin resistance, and NAFLD; however, there is no evidence on its relationship with albuminuria.	Iron	6-10	insulin	Homo sapiens	62-69
34266485-2	2021	As iron (Fe) SOD is absent in the human host, this enzyme is a promising molecular target for drug development against trypanosomatids.	Iron	3-7	superoxide dismutase 1	Homo sapiens	13-16
34266485-2	2021	As iron (Fe) SOD is absent in the human host, this enzyme is a promising molecular target for drug development against trypanosomatids.	Iron	9-11	superoxide dismutase 1	Homo sapiens	13-16
34357910-4	2021	PM2.5 and TSP contained high concentrations of heavy metals (Cu, Fe, Zn, and Pb).	Iron	65-67	thrombospondin 1	Homo sapiens	10-13
34236052-4	2021	Mice lacking FTH in the myeloid lineage (LysM-Cre+/+Fthfl/fl mice) displayed impaired iron storage capacities in the tissue leukocyte compartment, increased levels of labile iron in macrophages, and an accelerated macrophage-mediated iron turnover.	Iron	174-178	lysozyme 2	Mus musculus	41-45
34236052-4	2021	Mice lacking FTH in the myeloid lineage (LysM-Cre+/+Fthfl/fl mice) displayed impaired iron storage capacities in the tissue leukocyte compartment, increased levels of labile iron in macrophages, and an accelerated macrophage-mediated iron turnover.	Iron	234-238	lysozyme 2	Mus musculus	41-45
34236052-6	2021	iron supplementation drastically shortened survival of LysM-Cre+/+Fthfl/fl mice.	Iron	0-4	lysozyme 2	Mus musculus	55-59
34236052-9	2021	These findings uncover incompletely characterized roles of ferritin and cellular iron turnover in myeloid cells in controlling bacterial spread and for modulating NF-kappaB and inflammasome-mediated cytokine activation, which may be of vital importance in iron-overloaded individuals suffering from severe infections and sepsis.	Iron	81-85	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-172
34371810-9	2021	All groups receiving iron demonstrated an increase in transferrin saturation (TS%) in a dose-related manner, demonstrating that increases in serum iron are translated into increases in physiological iron transportation.	Iron	21-25	transferrin	Homo sapiens	54-65
34238598-13	2021	In the multivariate logistic regression, the "high" levels of CRP were directly correlated with the Log neutrophil-lymphocyte ratio (P<.001) and inversely proportional with serum albumin values (P=.014), Kt/V (P=.037) and serum iron (P<.001).	Iron	228-232	C-reactive protein	Homo sapiens	62-65
34281233-6	2021	Iron chelator-induced apoptosis was due to the activation of the MAPK signaling pathway, with increased phosphorylation levels of JNK, p38 and ERK, and ROS generation; in this process, the expression of C-caspase-3 and C-PARP increased.	Iron	0-4	mitogen-activated protein kinase 1	Mus musculus	143-146
34371810-9	2021	All groups receiving iron demonstrated an increase in transferrin saturation (TS%) in a dose-related manner, demonstrating that increases in serum iron are translated into increases in physiological iron transportation.	Iron	147-151	transferrin	Homo sapiens	54-65
34371810-9	2021	All groups receiving iron demonstrated an increase in transferrin saturation (TS%) in a dose-related manner, demonstrating that increases in serum iron are translated into increases in physiological iron transportation.	Iron	199-203	transferrin	Homo sapiens	54-65
34286134-1	2021	Pantothenate kinase-associated neurodegeneration (PKAN) is a rare hereditary neurodegenerative disease characterized by an accumulation of iron within the brain.	Iron	139-143	pantothenate kinase 2	Homo sapiens	0-48
34324404-3	2021	Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic.	Iron	50-54	transferrin	Homo sapiens	92-103
34077792-0	2021	Iron-loaded transferrin potentiates erythropoietin effects on erythroblast proliferation and survival: A novel role through transferrin receptors.	Iron	0-4	transferrin	Homo sapiens	12-23
34077792-0	2021	Iron-loaded transferrin potentiates erythropoietin effects on erythroblast proliferation and survival: A novel role through transferrin receptors.	Iron	0-4	erythropoietin	Homo sapiens	36-50
34077792-7	2021	Using an Epo-sensitive UT-7 (UT7/Epo) erythroid cell and human erythroid progenitor cell models, we report that iron-loaded transferrin, i.e., holo-transferrin (holo-Tf), synergizes with suboptimal Epo levels to improve erythroid cell survival, proliferation, and differentiation.	Iron	112-116	erythropoietin	Homo sapiens	9-12
34077792-7	2021	Using an Epo-sensitive UT-7 (UT7/Epo) erythroid cell and human erythroid progenitor cell models, we report that iron-loaded transferrin, i.e., holo-transferrin (holo-Tf), synergizes with suboptimal Epo levels to improve erythroid cell survival, proliferation, and differentiation.	Iron	112-116	transferrin	Homo sapiens	124-135
34077792-7	2021	Using an Epo-sensitive UT-7 (UT7/Epo) erythroid cell and human erythroid progenitor cell models, we report that iron-loaded transferrin, i.e., holo-transferrin (holo-Tf), synergizes with suboptimal Epo levels to improve erythroid cell survival, proliferation, and differentiation.	Iron	112-116	transferrin	Homo sapiens	148-159
34233389-3	2021	The specific structure and localization of PCBP2 lay the foundation for its multiple roles in transcriptional, posttranscriptional, and translational processes, even in iron metabolism.	Iron	169-173	poly(rC) binding protein 2	Homo sapiens	43-48
34037557-0	2021	Novel BMP6 gene mutation in patient with iron overload.	Iron	41-45	bone morphogenetic protein 6	Homo sapiens	6-10
34324404-3	2021	Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic.	Iron	165-169	transferrin	Homo sapiens	92-103
34324404-3	2021	Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic.	Iron	165-169	transferrin	Homo sapiens	147-158
34389106-4	2021	In addition, how circulating transferrin-bound iron contributes to the crosstalk between the 2 systems has started to be unraveled.	Iron	47-51	transferrin	Homo sapiens	29-40
34219855-4	2021	Hence, folic acid was added through a stabilized iodine solution, and B12 was added through the iron premix.	Iron	96-100	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	70-73
34219855-5	2021	Four approaches used to incorporate B12 into the iron premix were investigated: (1) co-extruding B12 with iron, (2) spraying B12 on the surface of the iron extrudate, (3) adding B12 to the colour masking agent, and (4) adding B12 to the outer coating.	Iron	49-53	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	36-39
34219855-5	2021	Four approaches used to incorporate B12 into the iron premix were investigated: (1) co-extruding B12 with iron, (2) spraying B12 on the surface of the iron extrudate, (3) adding B12 to the colour masking agent, and (4) adding B12 to the outer coating.	Iron	151-155	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	125-128
34240081-3	2021	This work explores an intracellular iron chelator transmetalative approach to inhibit RNR using the titanium(IV) chemical transferrin mimetic (cTfm) compounds Ti(HBED) and Ti(Deferasirox)2.	Iron	36-40	transferrin	Homo sapiens	122-133
34210014-1	2021	Human serum transferrin (HST) is a glycoprotein involved in iron transport that may be a candidate for functionalized nanoparticles to bind and target cancer cells.	Iron	60-64	fibroblast growth factor 4	Homo sapiens	25-28
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	91-95	iron responsive element binding protein 2	Homo sapiens	66-70
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	165-169	iron responsive element binding protein 2	Homo sapiens	66-70
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	199-203	iron responsive element binding protein 2	Homo sapiens	66-70
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	283-287	iron responsive element binding protein 2	Homo sapiens	66-70
34209797-7	2021	We found that a large amount of iron was released after cryo-thermal therapy and could be taken up by splenic macrophages, which further promoted M1 macrophage polarization by inhibiting ERK phosphorylation.	Iron	32-36	mitogen-activated protein kinase 1	Mus musculus	187-190
34258295-8	2021	Moreover, iron and the iron-sulfur (Fe-S) cluster influence each other, causing mitochondrial iron accumulation, more reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, failure in biosynthesis of insulin, and ferroptosis in beta-cells.	Iron	10-14	insulin	Homo sapiens	222-229
34183746-1	2021	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin (FPN1).	Iron	0-4	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	173-177
34183746-1	2021	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin (FPN1).	Iron	146-150	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	173-177
34258295-8	2021	Moreover, iron and the iron-sulfur (Fe-S) cluster influence each other, causing mitochondrial iron accumulation, more reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, failure in biosynthesis of insulin, and ferroptosis in beta-cells.	Iron	36-40	insulin	Homo sapiens	222-229
34345202-11	2021	As a downstream gene (effector) of Nrf2, heme oxygenase-1 (HO-1) expression increased significantly with the treatment of tagitinin C. Upregulated HO-1 led to the increase in the labile iron pool, which promoted lipid peroxidation, meanwhile tagitinin C showed synergistic anti-tumor effect together with erastin.	Iron	186-190	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
34161287-0	2021	The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential.	Iron	4-8	poly(rC) binding protein 1	Mus musculus	58-84
34154315-12	2021	(4) Among the 39 patients with anemia, 20 patients (51%, 20/39) withhold the treatment of PARP inhibitor due to grade III or IV anemia, including 10 patients (50%, 10/20) who resumed the PARP inhibitor treatment by suppling iron, folate, and vitamin B12.	Iron	224-228	poly(ADP-ribose) polymerase 1	Homo sapiens	187-191
34154315-15	2021	In the treatment of EOC, PARP inhibitor-related anemia mainly manifest as macrocytic orthochromatic anemia, and most patients with normal serum iron and transferrin.	Iron	144-148	poly(ADP-ribose) polymerase 1	Homo sapiens	25-29
34161397-0	2021	Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes.	Iron	0-4	SMAD family member 5	Homo sapiens	27-31
34161397-0	2021	Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes.	Iron	0-4	interleukin 6	Homo sapiens	36-40
34161397-0	2021	Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes.	Iron	0-4	signal transducer and activator of transcription 3	Homo sapiens	41-46
34161397-3	2021	Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liver sinusoidal endothelial cells, which in turn binds to BMP receptors on hepatocytes and induces the SMAD signaling cascade for transcriptional activation of the hepcidin-encoding HAMP mRNA.	Iron	0-4	bone morphogenetic protein 6	Homo sapiens	30-58
34161397-3	2021	Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liver sinusoidal endothelial cells, which in turn binds to BMP receptors on hepatocytes and induces the SMAD signaling cascade for transcriptional activation of the hepcidin-encoding HAMP mRNA.	Iron	0-4	bone morphogenetic protein 6	Homo sapiens	60-64
34161397-3	2021	Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liver sinusoidal endothelial cells, which in turn binds to BMP receptors on hepatocytes and induces the SMAD signaling cascade for transcriptional activation of the hepcidin-encoding HAMP mRNA.	Iron	0-4	SMAD family member 5	Homo sapiens	175-179
34161397-7	2021	Subsequent iron supplementation not only failed to reverse these effects, but drastically reduced basal HAMP mRNA and inhibited HAMP mRNA induction by BMP6 and/or IL-6.	Iron	11-15	bone morphogenetic protein 6	Homo sapiens	151-155
34161397-7	2021	Subsequent iron supplementation not only failed to reverse these effects, but drastically reduced basal HAMP mRNA and inhibited HAMP mRNA induction by BMP6 and/or IL-6.	Iron	11-15	interleukin 6	Homo sapiens	163-167
34161397-8	2021	Thus, treatment of cells with excess iron inhibited basal and BMP6-mediated SMAD5 phosphorylation and induction of HAMP, ID1 and SMAD7 mRNAs in a dose-dependent manner.	Iron	37-41	bone morphogenetic protein 6	Homo sapiens	62-66
34161397-8	2021	Thus, treatment of cells with excess iron inhibited basal and BMP6-mediated SMAD5 phosphorylation and induction of HAMP, ID1 and SMAD7 mRNAs in a dose-dependent manner.	Iron	37-41	SMAD family member 5	Homo sapiens	76-81
34161397-8	2021	Thus, treatment of cells with excess iron inhibited basal and BMP6-mediated SMAD5 phosphorylation and induction of HAMP, ID1 and SMAD7 mRNAs in a dose-dependent manner.	Iron	37-41	SMAD family member 7	Homo sapiens	129-134
34161397-9	2021	Iron also inhibited IL-6-mediated STAT3 phosphorylation and induction of HAMP and SOCS3 mRNAs.	Iron	0-4	interleukin 6	Homo sapiens	20-24
34161397-9	2021	Iron also inhibited IL-6-mediated STAT3 phosphorylation and induction of HAMP and SOCS3 mRNAs.	Iron	0-4	signal transducer and activator of transcription 3	Homo sapiens	34-39
34161397-11	2021	We conclude that hepatocellular iron overload suppresses hepcidin by inhibiting the SMAD and STAT3 signaling pathways downstream of their respective ligands.	Iron	32-36	SMAD family member 5	Homo sapiens	84-88
34161397-11	2021	We conclude that hepatocellular iron overload suppresses hepcidin by inhibiting the SMAD and STAT3 signaling pathways downstream of their respective ligands.	Iron	32-36	signal transducer and activator of transcription 3	Homo sapiens	93-98
34161287-1	2021	Poly(rC)-binding protein (PCBP1) is a multifunctional adaptor protein that can coordinate single-stranded nucleic acids and iron-glutathione complexes, altering the processing and transfer of these ligands through interactions with other proteins.	Iron	124-128	poly(rC) binding protein 1	Mus musculus	26-31
34161287-3	2021	Here, we report the identification of amino acid residues required for iron coordination on each structural domain of PCBP1 and confirm the requirement of iron coordination for binding target proteins BolA2 and ferritin.	Iron	71-75	poly(rC) binding protein 1	Mus musculus	118-123
34161287-3	2021	Here, we report the identification of amino acid residues required for iron coordination on each structural domain of PCBP1 and confirm the requirement of iron coordination for binding target proteins BolA2 and ferritin.	Iron	155-159	poly(rC) binding protein 1	Mus musculus	118-123
34161287-4	2021	We further construct PCBP1 variants that lack either nucleic acid- or iron-binding activity and examine their functions in human cells and mouse tissues depleted of endogenous PCBP1.	Iron	70-74	poly(rC) binding protein 1	Homo sapiens	21-26
34135606-3	2021	Transferrin (Tf) is a major iron transport protein in the body.	Iron	28-32	transferrin	Homo sapiens	0-11
34239727-9	2021	Therefore, this study aims to determine the correlations between iron overload (serum ferritin and transferrin saturation) and specific immune cells (CD4).	Iron	65-69	transferrin	Homo sapiens	99-110
34239727-9	2021	Therefore, this study aims to determine the correlations between iron overload (serum ferritin and transferrin saturation) and specific immune cells (CD4).	Iron	65-69	CD4 molecule	Homo sapiens	150-153
34220505-6	2021	In particular, Lf down-regulates the synthesis of IL-6, which is involved in iron homeostasis disorders and leads to intracellular iron overload, favoring viral replication and infection.	Iron	131-135	interleukin 6	Homo sapiens	50-54
34106939-9	2021	Long-term low stable Iron Age relative sea level can be seen in Dor, where Iron Age harbor structures remain around the same elevation between ca.	Iron	21-25	tumor protein p53 inducible nuclear protein 2	Homo sapiens	64-67
34106939-9	2021	Long-term low stable Iron Age relative sea level can be seen in Dor, where Iron Age harbor structures remain around the same elevation between ca.	Iron	75-79	tumor protein p53 inducible nuclear protein 2	Homo sapiens	64-67
34143808-0	2021	Intestinal iron absorption is appropriately modulated to match physiological demand for iron in wild-type and iron-loaded Hamp (hepcidin) knockout rats during acute colitis.	Iron	110-114	hepcidin antimicrobial peptide	Rattus norvegicus	122-126
34143808-0	2021	Intestinal iron absorption is appropriately modulated to match physiological demand for iron in wild-type and iron-loaded Hamp (hepcidin) knockout rats during acute colitis.	Iron	110-114	hepcidin antimicrobial peptide	Rattus norvegicus	128-136
34204310-1	2021	OBJECTIVE: The aim of this study was to evaluate non-transferrin-bound iron (NTBI) and labile plasma iron (LPI) levels and other parameters of iron metabolism in children undergoing therapy for acute leukemia or after hematopoietic cell transplantation (HCT), in the context of iron overload.	Iron	71-75	transferrin	Homo sapiens	53-64
34204310-1	2021	OBJECTIVE: The aim of this study was to evaluate non-transferrin-bound iron (NTBI) and labile plasma iron (LPI) levels and other parameters of iron metabolism in children undergoing therapy for acute leukemia or after hematopoietic cell transplantation (HCT), in the context of iron overload.	Iron	278-282	transferrin	Homo sapiens	53-64
34135606-3	2021	Transferrin (Tf) is a major iron transport protein in the body.	Iron	28-32	transferrin	Homo sapiens	13-15
34135606-6	2021	It is speculated that the mechanism may be that glycated modification reduces the binding ability of Tf and its receptor TfR, followed by excessive iron accumulation in the body.	Iron	148-152	transferrin	Homo sapiens	101-103
34135606-7	2021	Iron overload in the body may further lead to the death of pancreatic beta cells and insulin resistance by increasing oxidative stress, inducing iron death, interfering with the insulin signaling pathway, and causing autophagy deficiency.	Iron	0-4	insulin	Homo sapiens	85-92
34103572-2	2021	Here, we report the elastic wave velocities of delta-(Al,Fe)OOH (Fe/(Al + Fe) = 0.13, delta-Fe13) to 79 GPa, determined by nuclear resonant inelastic X-ray scattering.	Iron	57-59	glycophorin A (MNS blood group)	Homo sapiens	104-107
34135606-7	2021	Iron overload in the body may further lead to the death of pancreatic beta cells and insulin resistance by increasing oxidative stress, inducing iron death, interfering with the insulin signaling pathway, and causing autophagy deficiency.	Iron	0-4	insulin	Homo sapiens	178-185
34103572-2	2021	Here, we report the elastic wave velocities of delta-(Al,Fe)OOH (Fe/(Al + Fe) = 0.13, delta-Fe13) to 79 GPa, determined by nuclear resonant inelastic X-ray scattering.	Iron	65-67	glycophorin A (MNS blood group)	Homo sapiens	104-107
34103572-2	2021	Here, we report the elastic wave velocities of delta-(Al,Fe)OOH (Fe/(Al + Fe) = 0.13, delta-Fe13) to 79 GPa, determined by nuclear resonant inelastic X-ray scattering.	Iron	74-76	glycophorin A (MNS blood group)	Homo sapiens	104-107
34135606-7	2021	Iron overload in the body may further lead to the death of pancreatic beta cells and insulin resistance by increasing oxidative stress, inducing iron death, interfering with the insulin signaling pathway, and causing autophagy deficiency.	Iron	145-149	insulin	Homo sapiens	85-92
34795732-5	2021	Elevated iron stores were defined as serum ferritin level >300ng/ml, and transferrin saturation >45%.	Iron	9-13	transferrin	Homo sapiens	73-84
34199378-6	2021	These details support a complex dynamic interaction between the FXN and ISCU proteins when both are part of the NIAUF complex and this provides additional insight into the coordinated mechanism of Fe-S cluster assembly.	Iron	197-199	iron-sulfur cluster assembly enzyme	Homo sapiens	72-76
34068342-4	2021	In addition, several steps of the translation process depend on iron-containing enzymes, including particular modifications of translation elongation factors and transfer RNAs (tRNAs), and translation termination by the ATP-binding cassette family member Rli1 (ABCE1 in humans) and the prolyl hydroxylase Tpa1.	Iron	64-68	2-oxoglutarate and iron dependent oxygenase domain containing 1	Homo sapiens	305-309
34194691-6	2021	These simultaneous XES-XSS studies have provided detailed insight into the mechanism of light-induced spin crossover in iron coordination compounds, the interaction of CT and MC excited states in iron carbene photosensitizers, and the mechanism of Fe-S bond dissociation in cytochrome c.	Iron	248-250	cytochrome c, somatic	Homo sapiens	274-286
34094899-2	2021	Here we explored whether iron could promote the Warburg effect of colorectal cancer (CRC) cells and suppress sensitivity to ferroptosis by inducing reactive oxygen species (ROS) and regulating nuclear factor erythroid 2-related factor 2 (NRF2).	Iron	25-29	NFE2 like bZIP transcription factor 2	Homo sapiens	193-236
34094899-2	2021	Here we explored whether iron could promote the Warburg effect of colorectal cancer (CRC) cells and suppress sensitivity to ferroptosis by inducing reactive oxygen species (ROS) and regulating nuclear factor erythroid 2-related factor 2 (NRF2).	Iron	25-29	NFE2 like bZIP transcription factor 2	Homo sapiens	238-242
34094899-5	2021	Results showed that iron exposure promoted the Warburg effect of CRC cells by inducing ROS and activating NRF2 both in vivo and in vitro.	Iron	20-24	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
34064225-3	2021	A canonical IRE is a mRNA structure that interacts with the iron regulatory proteins (IRP1 and IRP2) to post-transcriptionally regulate the expression of proteins related to iron metabolism.	Iron	60-64	iron responsive element binding protein 2	Homo sapiens	95-99
34064225-3	2021	A canonical IRE is a mRNA structure that interacts with the iron regulatory proteins (IRP1 and IRP2) to post-transcriptionally regulate the expression of proteins related to iron metabolism.	Iron	174-178	iron responsive element binding protein 2	Homo sapiens	95-99
34063414-1	2021	Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1).	Iron	11-15	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	81-85
34063414-1	2021	Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1).	Iron	66-70	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	81-85
34063414-2	2021	The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes.	Iron	31-35	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	61-65
34063414-3	2021	In the genetic, iron-loading disorder hereditary hemochromatosis (HH), hepcidin production is low and Fpn1 protein expression is elevated.	Iron	16-20	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	102-106
34063414-4	2021	High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import.	Iron	19-23	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	5-9
34063414-4	2021	High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import.	Iron	54-58	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	5-9
34063252-4	2021	To be administered with different bread formulations, HFD-fed C57BL/6J mice were distributed in different groups: (i) wild type, (ii) displaying inherited disturbances in glucose homeostasis, and (iii) displaying dietary iron-mediated impairment of the innate immune TLR4/TRAM/TRIF pathway.	Iron	221-225	toll-like receptor 4	Mus musculus	267-271
34137530-2	2021	In iron overload states, high levels of iron exceed the iron-carrying capacity of transferrin within the plasma, leading to the formation of nontransferrin-bound iron form.	Iron	3-7	transferrin	Homo sapiens	82-93
34376935-10	2021	Conclusions: Intravenous AA as an adjuvant therapy with iron exerts a favorable and significant effect on the Hb, serum ferritin, and CRP levels in patients with ESKD having anemia.	Iron	56-60	C-reactive protein	Homo sapiens	134-137
34137530-2	2021	In iron overload states, high levels of iron exceed the iron-carrying capacity of transferrin within the plasma, leading to the formation of nontransferrin-bound iron form.	Iron	40-44	transferrin	Homo sapiens	82-93
34137530-2	2021	In iron overload states, high levels of iron exceed the iron-carrying capacity of transferrin within the plasma, leading to the formation of nontransferrin-bound iron form.	Iron	56-60	transferrin	Homo sapiens	82-93
34137530-2	2021	In iron overload states, high levels of iron exceed the iron-carrying capacity of transferrin within the plasma, leading to the formation of nontransferrin-bound iron form.	Iron	162-166	transferrin	Homo sapiens	82-93
35523353-3	2022	Fe(III) was anchored in nitrogen-coordinated pots (Fe-Nx) in the sp2-hybridized carbon network, and graphitic-N could synergistically boost the catalysis.	Iron	51-53	Sp2 transcription factor	Homo sapiens	65-68
34220068-6	2021	As only one-third of transferrin is saturated with iron, so the transferrin present in serum has the extra binding capacity (67%), this is called UIBC.	Iron	51-55	transferrin	Homo sapiens	21-32
34220068-6	2021	As only one-third of transferrin is saturated with iron, so the transferrin present in serum has the extra binding capacity (67%), this is called UIBC.	Iron	51-55	transferrin	Homo sapiens	64-75
34522246-8	2021	Iron level was negatively related to serum miR-96 level in healthy controls.	Iron	0-4	microRNA 96	Homo sapiens	43-49
35513087-2	2022	Family with sequence similarity 96 member A (FAM96A) is an evolutionarily conserved protein related to cytosolic iron assembly.	Iron	113-117	cytosolic iron-sulfur assembly component 2A	Homo sapiens	45-51
35395261-2	2022	This work proposes a new method of preparing Mg-Al-Fe Hydrotalcite-like compounds (MAF-HTCLs) by recycling DWTRs as the raw material to selectively adsorb anions in the waste water.	Iron	51-53	MAF bZIP transcription factor	Homo sapiens	83-86
34981175-1	2022	PURPOSE: To examine the relationship between apolipoprotein E gene (APOE) mutation status and iron accumulation in the deep gray matter of subjects with cognitive symptoms using quantitative susceptibility mapping (QSM).	Iron	94-98	apolipoprotein E	Homo sapiens	45-61
35525316-0	2022	Transcriptome analysis of developing zebrafish (Danio rerio) embryo following exposure to Gaudichaudione H reveals teratogenicity and cardiovascular defects caused by abnormal iron metabolism.	Iron	176-180	growth hormone 1	Danio rerio	90-106
35257767-0	2022	Multi-component removal of Pb(II), Cd(II), and As(V) over core-shell structured nanoscale zero-valent iron@mesoporous hydrated silica.	Iron	102-106	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	47-52
35257767-3	2022	Herein, the core-shell structured nanoscale zero-valent iron (nZVI) encapsulated with mesoporous hydrated silica (nZVI@mSiO2) were prepared for efficient removal of heavy metals including Pb(II), Cd(II), and metalloid As(V).	Iron	56-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	218-223
35523178-3	2022	Both IFN-gamma and iron treatment increased labile iron levels, but only iron treatment led to a consistent increase of ferritin levels, reflecting long-term iron storage.	Iron	51-55	interferon gamma	Homo sapiens	5-14
35523178-6	2022	Notably, iron-loaded microglia showed strong upregulation of cellular stress response pathways, the NRF2 pathway, and other oxidative stress pathways.	Iron	9-13	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
35447365-3	2022	The ferroptosis is mainly regulated by the metabolism of iron, lipids and amino acids through System Xc-, voltage-dependent anion channels, p53, p62-Keap1-Nrf2, mevalonate and other pathways.	Iron	57-61	tumor protein p53	Homo sapiens	140-143
35533575-5	2022	Mitophagy inhibitor Mdivi1 and iron chelators inhibited the myoferlin-related ROS production and restored cell growth.	Iron	31-35	myoferlin	Homo sapiens	60-69
35593209-4	2022	Like PICOT, yeast Grx3 and Grx4 reside in the cytosol and nucleus where they form unusual Fe-S clusters coordinated by two glutaredoxins with CGFS motifs and two molecules of glutathione.	Iron	90-92	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	27-31
35593209-5	2022	Depletion or deletion of Grx3/Grx4 leads to functional impairment of virtually all cellular iron-dependent processes and loss of cell viability, thus making these genes the most upstream components of the iron utilization system.	Iron	92-96	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	30-34
35593209-5	2022	Depletion or deletion of Grx3/Grx4 leads to functional impairment of virtually all cellular iron-dependent processes and loss of cell viability, thus making these genes the most upstream components of the iron utilization system.	Iron	205-209	monothiol glutaredoxin GRX4	Saccharomyces cerevisiae S288C	30-34
35593209-8	2022	Adopting a high copy-number library screen approach, we discovered novel genetic interactions: overexpression of ESL1, ESL2, SOK1, SFP1 or BDF2 partially rescues growth and iron utilization defects of Deltagrx3/4.	Iron	173-177	Bdf2p	Saccharomyces cerevisiae S288C	139-143
34981175-1	2022	PURPOSE: To examine the relationship between apolipoprotein E gene (APOE) mutation status and iron accumulation in the deep gray matter of subjects with cognitive symptoms using quantitative susceptibility mapping (QSM).	Iron	94-98	apolipoprotein E	Homo sapiens	68-72
34981175-8	2022	The APOE4 carrier group had higher magnetic susceptibility values than the non-carrier group, with significant differences in the caudate (p = 0.004), putamen (p < 0.0001), and globus pallidus (p < 0.0001) which imply higher iron accumulation.	Iron	225-229	apolipoprotein E	Homo sapiens	4-9
34981175-11	2022	It suggests that brain iron accumulation in the deep gray matter is modulated by APOE4 and age with differential regional predilection.	Iron	23-27	apolipoprotein E	Homo sapiens	81-86
35618957-2	2022	On one side iron is essential to terminal erythropoiesis for hemoglobin production, on the other erythropoiesis may increase iron absorption through the production of erythroferrone, the erythroid hormone that suppresses hepcidin expression Also erythropoietin production is modulated by iron through the iron regulatory proteins-iron responsive elements that control the hypoxia inducible factor 2-alpha.	Iron	12-16	erythropoietin	Homo sapiens	246-260
35179679-4	2022	Serum total iron binding capacity (TIBC), correlated with transferrin, is a nutritional status marker in HD patients and a biomarker of iron status.	Iron	12-16	transferrin	Homo sapiens	58-69
35346896-5	2022	Bioavailable of iron is thus acquired by ticks from the host serum transferrin.	Iron	16-20	transferrin	Homo sapiens	67-78
35490984-12	2022	RESULTS: We found that the expressions of LIP ROS, ROS, COX2, MDA and other oxidative factors increased, while the antioxidant markers GPX4, GSH and GSH-Px significantly decreased, as well as active iron accumulation in COPD patients, PM-exposured WT and Nrf2-KO mice models and PM2.5-mediated cell models.	Iron	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
35490984-12	2022	RESULTS: We found that the expressions of LIP ROS, ROS, COX2, MDA and other oxidative factors increased, while the antioxidant markers GPX4, GSH and GSH-Px significantly decreased, as well as active iron accumulation in COPD patients, PM-exposured WT and Nrf2-KO mice models and PM2.5-mediated cell models.	Iron	199-203	NFE2 like bZIP transcription factor 2	Homo sapiens	255-259
35190910-0	2022	Site-activated multi target iron chelators with acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitory activities for Alzheimer"s disease therapy.	Iron	28-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-68
35618957-3	2022	The second transferrin receptor, an iron sensor both in the liver and in erythroid cells modulates erythropoietin sensitivity and is a further link between hepcidin and erythropoiesis.	Iron	36-40	erythropoietin	Homo sapiens	99-113
35398023-1	2022	Non-transferrin-bound iron (NTBI) is an important biomarker related to the iron loading status of patients with certain diseases.	Iron	22-26	transferrin	Homo sapiens	4-15
35398023-1	2022	Non-transferrin-bound iron (NTBI) is an important biomarker related to the iron loading status of patients with certain diseases.	Iron	75-79	transferrin	Homo sapiens	4-15
35217123-0	2022	The effects of blunt snout bream (Megalobrama amblycephala) IL-6 trans-signaling on immunity and iron metabolism via JAK/STAT3 pathway.	Iron	97-101	interleukin 6	Homo sapiens	60-64
35217123-2	2022	However, the function of IL-6, especially the regulatory mechanism of IL-6 trans-signaling in immunity and iron metabolism remains largely unclear in teleost.	Iron	107-111	interleukin 6	Homo sapiens	70-74
35217123-9	2022	These findings provided novel insights into IL-6 trans-signaling regulatory mechanism in teleost, enriching our knowledge of fish immunity and iron metabolism.	Iron	143-147	interleukin 6	Homo sapiens	44-48
35603634-4	2022	Momelotinib is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of hepcidin expression and increased availability of iron for erythropoiesis.	Iron	145-149	Janus kinase 1	Homo sapiens	17-21
35637209-7	2022	XLSA clones exhibited significantly higher levels of intracellular lipid peroxides and enhanced expression of BACH1, a regulator of iron metabolism and potential accelerator of ferroptosis.	Iron	132-136	BTB domain and CNC homolog 1	Homo sapiens	110-115
35637209-8	2022	In XLSA clones, BACH1 repressed genes involved in iron metabolism and glutathione synthesis.	Iron	50-54	BTB domain and CNC homolog 1	Homo sapiens	16-21
35618963-4	2022	In addition, the role of iron in the modulation of Nrf2 response in macrophages is crucial and reviewed here.	Iron	25-29	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
35549239-1	2022	We present the very first density functional theory and dynamical mean field theory calculations of iron-bound human serum transferrin.	Iron	100-104	transferrin	Homo sapiens	123-134
35611976-6	2022	We found that the dissolution of Al, Cu, and Fe metal ions, predicted to be largely coordinated with organic compounds under fog conditions, was either immediate or considerably faster in samples collected on days with observed fog events compared with those collected on days having drier conditions.	Iron	45-47	zinc finger protein, FOG family member 1	Homo sapiens	125-128
35152109-1	2022	Since previous studies mostly ignored the contributions of Fe(IV) and Fe(V) during the determination of reaction rate constants of ferrate (Fe(VI)) with trace organic contaminants (TrOCs), the intrinsic oxidation ability of Fe(VI) was overestimated.	Iron	140-142	FEV transcription factor, ETS family member	Homo sapiens	70-75
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	157-161	erythropoietin	Homo sapiens	83-86
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	174-178	erythropoietin	Homo sapiens	67-81
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	174-178	erythropoietin	Homo sapiens	83-86
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	267-271	erythropoietin	Homo sapiens	67-81
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	267-271	erythropoietin	Homo sapiens	83-86
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	157-161	erythropoietin	Homo sapiens	67-81
35188161-3	2022	The redox properties of CoIIFeII have been investigated in DMF, revealing that this complex is the easiest to reduce by one-electron among the analogous MFe complexes (M = Ni, Fe, Co).	Iron	176-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-32
35584346-5	2022	For this subanalysis, ER expression in the biopsied metastasis was related to qualitative whole-body (18F)FES-PET evaluation and quantitative (18F)FES uptake in the corresponding metastasis.	Iron	106-109	estrogen receptor 1	Homo sapiens	22-24
35584346-5	2022	For this subanalysis, ER expression in the biopsied metastasis was related to qualitative whole-body (18F)FES-PET evaluation and quantitative (18F)FES uptake in the corresponding metastasis.	Iron	147-150	estrogen receptor 1	Homo sapiens	22-24
35584346-8	2022	Quantitative (18F)FES uptake predicted ER immunohistochemistry in the corresponding metastasis with a sensitivity/specificity of 91%/69% and a PPV/NPV of 90%/71% in 156 of 200 evaluable patients.	Iron	18-21	estrogen receptor 1	Homo sapiens	39-41
35152109-1	2022	Since previous studies mostly ignored the contributions of Fe(IV) and Fe(V) during the determination of reaction rate constants of ferrate (Fe(VI)) with trace organic contaminants (TrOCs), the intrinsic oxidation ability of Fe(VI) was overestimated.	Iron	224-226	FEV transcription factor, ETS family member	Homo sapiens	70-75
35152109-2	2022	For the first time, this study systemically evaluated the reactivity of Fe(VI) towards four kinds of TrOCs by blocking Fe(IV)/Fe(V) over the TrOCs degradation, and evaluated the effects of coexisting water matrix constituents.	Iron	119-121	FEV transcription factor, ETS family member	Homo sapiens	126-131
35152109-6	2022	HPO42- inhibited the reaction between Fe(VI) and H2O2, while Ca2+, Mg2+, and NH4+ promoted the generation of Fe(IV)/Fe(V) from Fe(VI).	Iron	38-40	FEV transcription factor, ETS family member	Homo sapiens	116-121
35152109-6	2022	HPO42- inhibited the reaction between Fe(VI) and H2O2, while Ca2+, Mg2+, and NH4+ promoted the generation of Fe(IV)/Fe(V) from Fe(VI).	Iron	109-111	FEV transcription factor, ETS family member	Homo sapiens	116-121
35152109-6	2022	HPO42- inhibited the reaction between Fe(VI) and H2O2, while Ca2+, Mg2+, and NH4+ promoted the generation of Fe(IV)/Fe(V) from Fe(VI).	Iron	127-129	FEV transcription factor, ETS family member	Homo sapiens	116-121
35152109-7	2022	Besides, humic acid could increase the contribution of Fe(IV)/Fe(V) to the oxidation of BPA.	Iron	55-57	FEV transcription factor, ETS family member	Homo sapiens	62-67
35563591-9	2022	Using HepG2 hepatoma cell and THP1 macrophage cultures, we found that iron, TDO2, and Trp degradation may act as important mediators of cross-communication between hepatocytes and macrophages regulating liver inflammation.	Iron	70-74	GLI family zinc finger 2	Homo sapiens	30-34
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-67
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	interleukin 6	Mus musculus	111-115
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	tumor necrosis factor	Mus musculus	117-125
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	superoxide dismutase 1, soluble	Mus musculus	214-218
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	catalase	Mus musculus	237-240
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	heme oxygenase 1	Mus musculus	242-247
35619717-1	2022	The enzyme heme oxygenase-1 (HO-1) has cytoprotective effects by catalyzing the degradation of heme to produce carbon monoxide, iron and biliverdin.	Iron	128-132	heme oxygenase 1	Mus musculus	11-27
35619717-1	2022	The enzyme heme oxygenase-1 (HO-1) has cytoprotective effects by catalyzing the degradation of heme to produce carbon monoxide, iron and biliverdin.	Iron	128-132	heme oxygenase 1	Mus musculus	29-33
35619717-3	2022	On the other hand, in the context of certain inflammatory conditions, HO-1 can induce iron overload and cell death.	Iron	86-90	heme oxygenase 1	Mus musculus	70-74
35619717-6	2022	However, only poor pregnancy outcomes in early pregnancy were related to HO-1 upregulation, iron overload, lipid peroxidation and necrosis of the decidua, which were prevented by HO-1 inhibition.	Iron	92-96	heme oxygenase 1	Mus musculus	179-183
35579155-5	2022	Meantime, immune cells release immunostimulatory cytokines including TNF-alpha and IFN-gamma to downregulate the expression of SLC7A11 and SLC3A2, and reduce the absorption of cysteine, leading to lipid peroxidation and iron deposition in cancer cells.	Iron	220-224	tumor necrosis factor	Homo sapiens	69-78
35579155-5	2022	Meantime, immune cells release immunostimulatory cytokines including TNF-alpha and IFN-gamma to downregulate the expression of SLC7A11 and SLC3A2, and reduce the absorption of cysteine, leading to lipid peroxidation and iron deposition in cancer cells.	Iron	220-224	interferon gamma	Homo sapiens	83-92
35545998-5	2022	Serum iron, transferrin saturation, non-transferrin-bound iron (NTBI) and ferritin were significantly increased in group 2.	Iron	58-62	transferrin	Homo sapiens	40-51
35628152-6	2022	Erythroferrone, a factor produced and secreted by erythroid precursors in response to erythropoietin, has been identified and characterized as a suppressor of hepcidin synthesis to allow iron mobilization and facilitate erythropoiesis.	Iron	187-191	erythropoietin	Homo sapiens	86-100
35615522-0	2022	Comparative Thermophysiology of Marine Synechococcus CRD1 Strains Isolated From Different Thermal Niches in Iron-Depleted Areas.	Iron	108-112	CORD1	Homo sapiens	53-57
35615522-4	2022	A fifth clade, CRD1, was recently shown to dominate the Synechococcus community in iron-depleted areas of the world ocean and to encompass three distinct ecologically significant taxonomic units (ESTUs CRD1A-C) occupying different thermal niches, suggesting that distinct thermotypes could also occur within this clade.	Iron	83-87	CORD1	Homo sapiens	15-19
35615522-8	2022	Together, our data suggests that the CRD1 clade prioritizes adaptation to low-iron conditions over temperature adaptation, even though the occurrence of several CRD1 thermotypes likely explains why the CRD1 clade as a whole occupies most iron-limited waters.	Iron	78-82	CORD1	Homo sapiens	37-41
35599858-10	2022	We determined that iron distribution is modified in abi3, lec2, and fus3 embryo mutants.	Iron	19-23	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	58-62
35599858-12	2022	lec2-1 embryos showed no difference in the pattern of iron distribution in hypocotyl, but a dramatic decrease of iron was observed in cotyledons.	Iron	113-117	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	0-4
35599858-15	2022	Altogether our results support a role of the B3 transcription factors ABI3, LEC2, and FUS3 in maintaining iron homeostasis in Arabidopsis embryos.	Iron	106-110	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	76-80
35507910-0	2022	Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.	Iron	130-134	leucine rich repeat kinase 2	Homo sapiens	25-30
35525219-7	2022	Mechanistically, CdTe QDs-provoked decrease of nuclear factor erythroid 2-related factor 2 (NRF2) elicited phosphorylation of extracellular regulated protein kinases1/2 (ERK1/2) and then activated ferritinophagy, which made ferritin heavy chain 1 (FTH1) degraded in lysosome and proteasome to release free iron ions to initiate ferroptosis in macrophages.	Iron	306-310	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-90
35525219-7	2022	Mechanistically, CdTe QDs-provoked decrease of nuclear factor erythroid 2-related factor 2 (NRF2) elicited phosphorylation of extracellular regulated protein kinases1/2 (ERK1/2) and then activated ferritinophagy, which made ferritin heavy chain 1 (FTH1) degraded in lysosome and proteasome to release free iron ions to initiate ferroptosis in macrophages.	Iron	306-310	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
35507910-0	2022	Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.	Iron	130-134	transferrin	Homo sapiens	109-120
35499081-2	2022	Notably, iron is required for activated CD4+ T lymphocytes to sustain high proliferation and metabolism.	Iron	9-13	CD4 molecule	Homo sapiens	40-43
35505371-1	2022	BACKGROUND: Ferroptosis is an iron dependent cell death closely associated with p53 signaling pathway and is aberrantly regulated in glioblastoma (GBM), yet the underlying mechanism needs more exploration.	Iron	30-34	tumor protein p53	Homo sapiens	80-83
35499081-4	2022	showed that CD4+ T cells from patients with SLE accumulated iron, augmenting their differentiation into Tfh cells and correlating with disease activity.	Iron	60-64	CD4 molecule	Homo sapiens	12-15
35538889-0	2022	AMP-activated protein kinase alpha1 phosphorylates PHD2 to maintain systemic iron homeostasis.	Iron	77-81	brain protein 1	Mus musculus	29-35
35538889-7	2022	RESULTS: We found that mice with global deficiency of AMPKalpha1, but not AMPKalpha2, exhibited hypoferraemia as well as iron sequestration in the spleen and liver.	Iron	121-125	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	54-64
35538889-8	2022	Hepatocyte-specific, but not myeloid-specific, ablation of AMPKalpha1 also reduced serum iron levels in association with increased hepcidin and decreased ferroportin protein levels.	Iron	89-93	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	59-69
35106609-0	2022	Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway.	Iron	61-65	thymoma viral proto-oncogene 1	Mus musculus	90-93
35538889-9	2022	Mechanistically, AMPKalpha1 directly phosphorylated prolyl hydroxylase domain-containing (PHD)2 at serines 61 and 136, which suppressed PHD2-dependent hydroxylation of hypoxia-inducible factor (HIF)1alpha and subsequent regulation of hepatic hepcidin-related iron signalling.	Iron	259-263	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	17-27
35538889-12	2022	CONCLUSION: In conclusion, these observations suggest that hepatic AMPKalpha1 has an essential role in maintaining iron homeostasis by PHD2-dependent regulation of hepcidin, thus providing a potentially promising approach for the treatment of iron disturbances in chronic diseases.	Iron	115-119	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	67-77
35538889-12	2022	CONCLUSION: In conclusion, these observations suggest that hepatic AMPKalpha1 has an essential role in maintaining iron homeostasis by PHD2-dependent regulation of hepcidin, thus providing a potentially promising approach for the treatment of iron disturbances in chronic diseases.	Iron	243-247	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	67-77
35187967-6	2022	The splenocytes generated moderate amounts of ROS and released high amounts of tumor necrosis factor (TNF)-alpha in response to lipopolysaccharide, indicating excessive inflammatory cytokine released by activated macrophages in iron-accumulating spleens.	Iron	228-232	tumor necrosis factor	Mus musculus	79-112
35106609-0	2022	Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway.	Iron	61-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
35106609-12	2022	CONCLUSION: These findings indicated hops and xanthohumol could ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway, which brought up a novel sight for senile osteoporosis therapy.	Iron	96-100	thymoma viral proto-oncogene 1	Mus musculus	125-128
35106609-12	2022	CONCLUSION: These findings indicated hops and xanthohumol could ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway, which brought up a novel sight for senile osteoporosis therapy.	Iron	96-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
35101526-0	2022	COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.	Iron	96-98	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-26
35195807-5	2022	Nuclear factor NF-E2-related factor (Nrf2) has been considered as a major regulator of antioxidant in previous studies, but recent studies have revealed that insufficient cellular autophagy can turn off Nrf2-mediated antioxidant defense while initiating Nrf2-manipulated iron deposition and lipid peroxidation, leading to the development of iron ferroptosis.	Iron	271-275	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
35297168-3	2022	A series of basic helix-loop-helix (bHLH) TFs have been shown to contribute to Fe homeostasis, but the regulatory layers beyond bHLH TFs remain largely unclear.	Iron	79-81	basic helix-loop-helix	Solanum lycopersicum	12-34
35297168-3	2022	A series of basic helix-loop-helix (bHLH) TFs have been shown to contribute to Fe homeostasis, but the regulatory layers beyond bHLH TFs remain largely unclear.	Iron	79-81	basic helix-loop-helix	Solanum lycopersicum	36-40
35195807-5	2022	Nuclear factor NF-E2-related factor (Nrf2) has been considered as a major regulator of antioxidant in previous studies, but recent studies have revealed that insufficient cellular autophagy can turn off Nrf2-mediated antioxidant defense while initiating Nrf2-manipulated iron deposition and lipid peroxidation, leading to the development of iron ferroptosis.	Iron	271-275	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
35195807-5	2022	Nuclear factor NF-E2-related factor (Nrf2) has been considered as a major regulator of antioxidant in previous studies, but recent studies have revealed that insufficient cellular autophagy can turn off Nrf2-mediated antioxidant defense while initiating Nrf2-manipulated iron deposition and lipid peroxidation, leading to the development of iron ferroptosis.	Iron	341-345	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
35195807-5	2022	Nuclear factor NF-E2-related factor (Nrf2) has been considered as a major regulator of antioxidant in previous studies, but recent studies have revealed that insufficient cellular autophagy can turn off Nrf2-mediated antioxidant defense while initiating Nrf2-manipulated iron deposition and lipid peroxidation, leading to the development of iron ferroptosis.	Iron	341-345	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
35322867-10	2022	Furthermore, IFNgamma enhanced erastin-induced ferroptosis, as evidenced by the accumulation of iron, as well as the increase in lipid peroxidation and promotion of mitochondrial damage.	Iron	96-100	interferon gamma	Homo sapiens	13-21
35258778-0	2022	Carbon Monoxide Protects Neural Stem Cells Against Iron Overload by Modulating the Crosstalk Between Nrf2 and NF-kappaB Signaling.	Iron	51-55	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
35258778-0	2022	Carbon Monoxide Protects Neural Stem Cells Against Iron Overload by Modulating the Crosstalk Between Nrf2 and NF-kappaB Signaling.	Iron	51-55	nuclear factor kappa B subunit 1	Homo sapiens	110-119
35451223-3	2022	The Ac-beta-CD-DHA based nanoparticles are coated by an iron-containing polyphenol network.	Iron	56-60	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	7-14
35290903-1	2022	A cytosolic iron chaperone poly(rC)-binding protein 1 (PCBP1) is a multifunctional RNA-binding protein involving gene transcription, RNA regulation, and iron loading to ferritins.	Iron	12-16	poly(rC) binding protein 1	Mus musculus	27-53
35290903-1	2022	A cytosolic iron chaperone poly(rC)-binding protein 1 (PCBP1) is a multifunctional RNA-binding protein involving gene transcription, RNA regulation, and iron loading to ferritins.	Iron	12-16	poly(rC) binding protein 1	Mus musculus	55-60
35290903-1	2022	A cytosolic iron chaperone poly(rC)-binding protein 1 (PCBP1) is a multifunctional RNA-binding protein involving gene transcription, RNA regulation, and iron loading to ferritins.	Iron	153-157	poly(rC) binding protein 1	Mus musculus	27-53
35290903-1	2022	A cytosolic iron chaperone poly(rC)-binding protein 1 (PCBP1) is a multifunctional RNA-binding protein involving gene transcription, RNA regulation, and iron loading to ferritins.	Iron	153-157	poly(rC) binding protein 1	Mus musculus	55-60
35290903-11	2022	Further, excess iron accumulation caused mitochondrial dysfunction in PCBP1-suppressed cells.	Iron	16-20	poly(rC) binding protein 1	Mus musculus	70-75
35397396-2	2022	Mutations in PPCS cause autosomal-recessive dilated cardiomyopathy, often fatal, without apparent neurodegeneration, whereas pathogenic variants in PANK2 and COASY, two other genes involved in the CoA synthesis, cause Neurodegeneration with Brain Iron Accumulation (NBIA).	Iron	247-251	pantothenate kinase 2	Homo sapiens	148-153
35397396-2	2022	Mutations in PPCS cause autosomal-recessive dilated cardiomyopathy, often fatal, without apparent neurodegeneration, whereas pathogenic variants in PANK2 and COASY, two other genes involved in the CoA synthesis, cause Neurodegeneration with Brain Iron Accumulation (NBIA).	Iron	247-251	Coenzyme A synthase	Homo sapiens	158-163
35570856-1	2022	Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation of EPO antibodies.	Iron	127-131	erythropoietin	Homo sapiens	68-82
35570856-1	2022	Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation of EPO antibodies.	Iron	127-131	erythropoietin	Homo sapiens	84-87
35487763-1	2022	Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes.	Iron	165-169	transferrin	Rattus norvegicus	147-158
35472080-4	2022	Mice deficient for autophagy in macrophages (LysM-Atg5-/-) mimicked a primary iron overload phenotype, resulting in high ferroportin expression in both macrophages and enterocytes that correlated with marked parenchymal iron overload.	Iron	220-224	lysozyme 2	Mus musculus	45-49
35602944-4	2022	In particular, we intentionally modify the Fe/Pt interface by inserting an ordered L10-FePt alloy interlayer.	Iron	43-45	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	83-86
35483916-0	2022	APOE e4 dose associates with increased brain iron and beta-amyloid via blood-brain barrier dysfunction.	Iron	45-49	apolipoprotein E	Homo sapiens	0-4
35483916-1	2022	OBJECTIVE: To examine the effect of apolipoprotein E (APOE) e4 dose on blood-brain barrier (BBB) clearance function, evaluated using an advanced MRI technique and analyse its correlation with brain iron and beta-amyloid accumulation in the early stages of the Alzheimer"s continuum.	Iron	198-202	apolipoprotein E	Homo sapiens	36-52
35483916-1	2022	OBJECTIVE: To examine the effect of apolipoprotein E (APOE) e4 dose on blood-brain barrier (BBB) clearance function, evaluated using an advanced MRI technique and analyse its correlation with brain iron and beta-amyloid accumulation in the early stages of the Alzheimer"s continuum.	Iron	198-202	apolipoprotein E	Homo sapiens	54-58
35483916-7	2022	INTERPRETATION: Our results suggest that an increased APOE e4 dose is associated with decreased effective brain-waste clearance, such as iron and beta-amyloid, through the BBB.	Iron	137-141	apolipoprotein E	Homo sapiens	54-58
35484240-4	2022	Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway.	Iron	99-103	apolipoprotein E	Homo sapiens	84-88
35484240-4	2022	Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway.	Iron	180-184	apolipoprotein E	Homo sapiens	84-88
35484240-6	2022	We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation.	Iron	156-160	apolipoprotein E	Homo sapiens	20-24
35484240-6	2022	We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation.	Iron	156-160	AKT serine/threonine kinase 1	Homo sapiens	54-57
35484240-7	2022	Using postmortem inferior temporal brain cortex tissue from deceased subjects from the Rush Memory and Aging Project (MAP) (N = 608), we found that the association of iron with pathologically confirmed clinical Alzheimer"s disease was stronger among those with the adverse APOE-epsilon4 allele.	Iron	167-171	apolipoprotein E	Homo sapiens	273-277
35472080-5	2022	Furthermore, LysM-Atg5-/- mice exhibited increased hematopoietic activity with no sign of anemia but correlating with rather high plasma iron level.	Iron	137-141	lysozyme 2	Mus musculus	13-17
35472080-6	2022	Compared to wild-type cells, bone marrow-derived macrophages from LysM-Atg5-/- mice had significantly increased ferroportin expression and a decreased iron content, confirming high iron export.	Iron	151-155	lysozyme 2	Mus musculus	66-70
35473528-3	2022	Objective:In this study, we proposed to construct high expression of Ferroportin1 macrophages as carriers to deliver Fe3O4-nanoparticles and iron directly to tumor sites.	Iron	141-145	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-81
35472080-8	2022	Relatively high hepatic hepcidin expression, and decreased hepcidin level in the spleen of LysM-Atg5-/- mice correlating with low hemosiderin iron storage as well as in erythrophagocytic Atg5-/- macrophages were evidenced.	Iron	142-146	lysozyme 2	Mus musculus	91-95
35473528-7	2022	Fe3O4-NPs in Ana-1 cells were degraded in lysosomes, and the amount of iron released was correlated with the expression of ferroportin1.	Iron	71-75	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	123-135
35473528-10	2022	Ana-1-FPN1 cells increases intracellular iron release.	Iron	41-45	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	6-10
35630141-0	2022	Electrochemical Detection of Alpha-Fetoprotein Based on Black Phosphorus Nanosheets Modification with Iron Ions.	Iron	102-106	alpha fetoprotein	Homo sapiens	29-46
35473528-13	2022	Moreover, increase of intracellular iron efflux by overexpression of FPN1, cell carriers can act as a reservoir for iron, providing the basis for targeted delivery of Fe3O4-NPs and iron ions in vivo.	Iron	36-40	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-73
35473528-13	2022	Moreover, increase of intracellular iron efflux by overexpression of FPN1, cell carriers can act as a reservoir for iron, providing the basis for targeted delivery of Fe3O4-NPs and iron ions in vivo.	Iron	116-120	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-73
35473528-13	2022	Moreover, increase of intracellular iron efflux by overexpression of FPN1, cell carriers can act as a reservoir for iron, providing the basis for targeted delivery of Fe3O4-NPs and iron ions in vivo.	Iron	181-185	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-73
35404120-7	2022	Transcriptional profiling of Histoplasma yeasts identified a small regulon of Mac1-dependent genes, with the most strongly regulated genes encoding proteins linked to copper, iron, and zinc homeostasis and defenses against reactive oxygen (iron-requiring catalase (CatB) and superoxide dismutase (Sod4)).	Iron	175-179	Mac1p	Saccharomyces cerevisiae S288C	78-82
35404120-7	2022	Transcriptional profiling of Histoplasma yeasts identified a small regulon of Mac1-dependent genes, with the most strongly regulated genes encoding proteins linked to copper, iron, and zinc homeostasis and defenses against reactive oxygen (iron-requiring catalase (CatB) and superoxide dismutase (Sod4)).	Iron	240-244	Mac1p	Saccharomyces cerevisiae S288C	78-82
35404120-8	2022	Accordingly, the loss of Mac1 function increased sensitivity to copper and iron restriction and blocked low-copper-induced expression of extracellular catalase activity.	Iron	75-79	Mac1p	Saccharomyces cerevisiae S288C	25-29
35460695-4	2022	In addition, we show that phlebotomy decreased iron accumulation in old mice, partially restoring the metabolic patterns and amplitudes of the oscillatory expression of clock genes Per1 and Per2.	Iron	47-51	period circadian clock 2	Mus musculus	190-194
35460388-10	2022	After 2 months of oral iron therapy, there was a significant improvement in hemoglobin, mean corpuscular volume, serum iron, total iron-binding capacity, and transferrin saturation in both groups.	Iron	23-27	transferrin	Homo sapiens	158-169
35466452-5	2022	In daily practice, the most effective biomarkers of iron status are serum ferritin, which reflects iron storage, and transferrin saturation, which reflects the transport of iron.	Iron	52-56	transferrin	Homo sapiens	117-128
35466452-5	2022	In daily practice, the most effective biomarkers of iron status are serum ferritin, which reflects iron storage, and transferrin saturation, which reflects the transport of iron.	Iron	173-177	transferrin	Homo sapiens	117-128
35460695-0	2022	Iron Accumulation with Age alters Metabolic Pattern and Circadian Clock gene expression through the reduction of AMP-modulated Histone Methylation.	Iron	0-4	circadian locomotor output cycles kaput	Mus musculus	66-71
35460695-2	2022	Here we report that both high-iron diet and advanced age in mice consistently altered gene expression of many pathways, including those governing the oxidative stress response and the circadian clock.	Iron	30-34	circadian locomotor output cycles kaput	Mus musculus	194-199
35460695-3	2022	We used a metabolomic approach to reveal similarities between metabolic profiles and the daily oscillation of clock genes in old and iron-overloaded mouse livers.	Iron	133-137	circadian locomotor output cycles kaput	Mus musculus	110-115
35460695-5	2022	We further identified that the transcriptional regulation of iron occurred through a reduction in AMP-modulated methylation of histone H3K9 in the Per1 and H3K4 in the Per2 promoters, respectively.	Iron	61-65	period circadian clock 2	Mus musculus	168-172
35460695-6	2022	Taken together, our results indicate that iron accumulation with age can affect metabolic patterns and the circadian clock.	Iron	42-46	circadian locomotor output cycles kaput	Mus musculus	117-122
35453472-2	2022	Glutaredoxin 5 (Glrx5) is a mitochondrial protein involved in the assembly of iron-sulfur clusters required for complexes of the respiratory chain.	Iron	78-82	glutaredoxin 5	Mus musculus	0-14
35602653-0	2022	Disruption of cellular iron homeostasis by IREB2 missense variants causes severe neurodevelopmental delay, dystonia and seizures.	Iron	23-27	iron responsive element binding protein 2	Homo sapiens	43-48
35602653-2	2022	Intracellular iron homeostasis in mammals is maintained by two homologous ubiquitously expressed iron-responsive element-binding proteins (IRP1 and IRP2).	Iron	14-18	iron responsive element binding protein 2	Homo sapiens	148-152
35602653-2	2022	Intracellular iron homeostasis in mammals is maintained by two homologous ubiquitously expressed iron-responsive element-binding proteins (IRP1 and IRP2).	Iron	97-101	iron responsive element binding protein 2	Homo sapiens	148-152
35602653-7	2022	These results, in addition to confirming the essential role of IRP2 in the regulation of iron metabolism in humans, expand the scope of the known IRP2-related neurodegenerative disorders and underscore that IREB2 pathological variants may impact the iron-responsive element-binding activity of IRP2 with varying degrees of severity.	Iron	89-93	iron responsive element binding protein 2	Homo sapiens	63-67
35602653-7	2022	These results, in addition to confirming the essential role of IRP2 in the regulation of iron metabolism in humans, expand the scope of the known IRP2-related neurodegenerative disorders and underscore that IREB2 pathological variants may impact the iron-responsive element-binding activity of IRP2 with varying degrees of severity.	Iron	89-93	iron responsive element binding protein 2	Homo sapiens	207-212
35442939-3	2022	Iron metabolism disorders and metabolic derangements have been generally accepted as predisposing elements in RLS.	Iron	0-4	RLS1	Homo sapiens	110-113
35602653-7	2022	These results, in addition to confirming the essential role of IRP2 in the regulation of iron metabolism in humans, expand the scope of the known IRP2-related neurodegenerative disorders and underscore that IREB2 pathological variants may impact the iron-responsive element-binding activity of IRP2 with varying degrees of severity.	Iron	250-254	iron responsive element binding protein 2	Homo sapiens	207-212
35631320-13	2022	We concluded that heme-induced upregulation of the Nrf2/HO-1 system inhibits HuLECs calcification through the liberation of heme iron.	Iron	129-133	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
35457224-2	2022	DMT1 has a vital role in iron homeostasis by mediating iron uptake in the intestine and kidneys and by recovering iron from recycling endosomes after transferrin endocytosis.	Iron	25-29	transferrin	Homo sapiens	150-161
35457224-2	2022	DMT1 has a vital role in iron homeostasis by mediating iron uptake in the intestine and kidneys and by recovering iron from recycling endosomes after transferrin endocytosis.	Iron	114-118	transferrin	Homo sapiens	150-161
35453472-2	2022	Glutaredoxin 5 (Glrx5) is a mitochondrial protein involved in the assembly of iron-sulfur clusters required for complexes of the respiratory chain.	Iron	78-82	glutaredoxin 5	Mus musculus	16-21
35457224-9	2022	We also suggest that recombinant erythropoietin would be an adequate therapeutic approach for AHMIO1 patients as it improves their anemic state and may possibly contribute to mobilizing excessive hepatic iron.	Iron	204-208	erythropoietin	Homo sapiens	33-47
35413222-4	2022	We found that Hmox-1-/- mice had elevated plasma endothelin-1 (ET-1), cortical ET-1 mRNA expression, and renal iron content compared to Hmox-1+/+ controls.	Iron	111-115	heme oxygenase 1	Mus musculus	14-20
35497774-2	2022	The present work aimed to encapsulate iron in a water-in-oil-in-water double emulsion (W1/O/W2), which was formed with whey protein isolate and polyglycerol polyricinoleate as the emulsifying agents, tara gum as a thickening agent, and sucrose as an osmotic active substance.	Iron	38-42	TRIO and F-actin binding protein	Homo sapiens	200-204
35051552-6	2022	Knockdown of ELAVL1 reduced iron level and oxidative stress, promoted osteogensis, and prevented bone mass loss, thus mitigating DOP in DM mice.	Iron	28-32	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	13-19
35051552-8	2022	The inhibitory effects of ELAVL1 knockdown on iron accumulation and oxidative stress were evidenced in MC3T3-E1 cells.	Iron	46-50	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	26-32
35051552-12	2022	In conclusion, knockdown of ELAVL1 likely alleviated DOP by inhibiting iron overload and oxidative stress and promoting osteogenesis, and DMT1 might be involved in this process.	Iron	71-75	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	28-34
35458175-3	2022	According to the joint quartiles of baseline transferrin saturation and ferritin, iron status was categorized as reference iron status (RIS), absolute iron deficiency (AID), functional iron deficiency (FID), and high iron status (HIS).	Iron	82-86	transferrin	Homo sapiens	45-56
35413222-7	2022	Finally, ambrisentan had an important iron recycling effect by increasing expression of cellular iron exporter, ferroportin-1 (FPN-1) and circulating total iron levels in Hmox-1-/- mice.	Iron	156-160	heme oxygenase 1	Mus musculus	171-177
35413712-1	2022	INTRODUCTION: Dysregulation of iron metabolism is closely associated with the development of obesity and obstructive sleep apnea (OSA), but little is known about the relationship between serum transferrin (TF) level and OSA severity.	Iron	31-35	transferrin	Homo sapiens	193-204
35413712-1	2022	INTRODUCTION: Dysregulation of iron metabolism is closely associated with the development of obesity and obstructive sleep apnea (OSA), but little is known about the relationship between serum transferrin (TF) level and OSA severity.	Iron	31-35	transferrin	Homo sapiens	206-208
35385924-2	2022	One of the main causes of AoC is cancer-associated inflammation that activates mechanisms, commonly observed in anemia of inflammation, where functional iron deficiency and iron-restricted erythropoiesis is induced by increased hepcidin levels in response to IL-6 elevation.	Iron	173-177	interleukin 6	Homo sapiens	259-263
35496960-0	2022	Evaluation of Iron Status by Reticulocyte Haemoglobin Content (Chr) in Chronic Kidney Disease Patients on Haemodialysis and Erythropoietin.	Iron	14-18	erythropoietin	Homo sapiens	124-138
35384646-4	2022	Herein, Fe/Mn-based metal-organic frameworks (FMM) were constructed for the delivery of a specific DNAzyme with high catalytic cleavage activity on the metastasis-involved Twist mRNA, thus efficiently inhibiting the invasion of cancer cells through DNAzyme-catalyzed gene silencing.	Iron	8-10	twist family bHLH transcription factor 1	Homo sapiens	172-177
35319885-6	2022	Experiments with scavengers (tert-butyl alcohol and methyl phenyl sulfoxide) and a probe compound (benzoic acid) confirmed that high-valent iron species (Fe(IV) and/or Fe(V)), rather than radicals, are the major reactive species contributing to MP degradation.	Iron	140-144	FEV transcription factor, ETS family member	Homo sapiens	168-173
35130741-2	2022	Under iron overload conditions, transferrin (Tf) saturation leads to an increase in non-Tf bound iron which can result in the generation of reactive oxygen species (ROS).	Iron	6-10	transferrin	Homo sapiens	32-43
35130741-2	2022	Under iron overload conditions, transferrin (Tf) saturation leads to an increase in non-Tf bound iron which can result in the generation of reactive oxygen species (ROS).	Iron	97-101	transferrin	Homo sapiens	32-43
35448720-6	2022	In comparison, 18F-fluoroestradiol (18F-FES) is a novel estrogen-receptor-specific PET radiotracer, which more accurately assesses the intracranial and intraorbital compartments in patients with estrogen-receptor-positive (ER+) cancers than 18F-FDG, due to lack of physiologic background activity in these regions.	Iron	40-43	estrogen receptor 1	Homo sapiens	56-73
35448720-6	2022	In comparison, 18F-fluoroestradiol (18F-FES) is a novel estrogen-receptor-specific PET radiotracer, which more accurately assesses the intracranial and intraorbital compartments in patients with estrogen-receptor-positive (ER+) cancers than 18F-FDG, due to lack of physiologic background activity in these regions.	Iron	40-43	estrogen receptor 1	Homo sapiens	195-212
35192961-7	2022	Reduced AKT kinase signaling results in intracellular glucose deprivation, which causes endoplasmic reticulum stress and iron depletion, leading to activation of HIF-1alpha, the transcription factor necessary for higher Glut expression.	Iron	121-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-172
35235042-6	2022	The magnitude of the overall binding constants (beta2 values) are discussed and related to (a) the pKa values of the free ligands and (b) the Mossbauer parameter DeltaEQ, which represents the quadrupole splitting of the haem iron.	Iron	225-229	ATPase H+ transporting V0 subunit a2	Homo sapiens	48-53
35383762-3	2022	Transfusion dependent iron over load cause decrease secretion of growth hormone, insulin, thyroid hormone, parathyroid hormone, sex hormone and vitamin D from different endocrine organs which ultimately causes impairment of adequate bone mass achievement.	Iron	22-26	growth hormone 1	Homo sapiens	65-79
35218676-2	2022	MGST1 (microsomal glutathione S-transferase 1) involves in the regulation of oxidative stress and plays a key role in inhibiting iron-mediated cell death in cancer cells.	Iron	129-133	microsomal glutathione S-transferase 1	Homo sapiens	0-5
35218676-2	2022	MGST1 (microsomal glutathione S-transferase 1) involves in the regulation of oxidative stress and plays a key role in inhibiting iron-mediated cell death in cancer cells.	Iron	129-133	microsomal glutathione S-transferase 1	Homo sapiens	7-45
35063763-0	2022	Removal of As(V) from wastewaters using magnetic iron oxides formed by zero-valent iron electrocoagulation.	Iron	83-87	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	11-16
35063763-2	2022	In this work, zero-valent iron was electrochemically oxidized to magnetic iron oxides for the removal of As(V) from simulated and actual mining wastewaters.	Iron	26-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-110
35063763-4	2022	In simulated As(V)-containing solution with initial pH 7.0, zero-valent iron was electrochemically oxidized to magnetite and maghemite at 0.6 V (vs. SCE) for 2 h. The As(V) concentration first decreased from 5127.5 to 26.8 mug L-1 with a removal ratio of 99.5%.	Iron	72-76	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	13-18
35063763-4	2022	In simulated As(V)-containing solution with initial pH 7.0, zero-valent iron was electrochemically oxidized to magnetite and maghemite at 0.6 V (vs. SCE) for 2 h. The As(V) concentration first decreased from 5127.5 to 26.8 mug L-1 with a removal ratio of 99.5%.	Iron	72-76	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	167-172
35063763-5	2022	In actual mining wastewaters, zero-valent iron was electrochemically oxidized to maghemite at 0.6 V (vs. SCE) for 24 h, and the As(V) concentration decreased from 5486.4 to 3.6 mug L-1 with a removal ratio of 99.9%.	Iron	42-46	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	128-133
35383762-3	2022	Transfusion dependent iron over load cause decrease secretion of growth hormone, insulin, thyroid hormone, parathyroid hormone, sex hormone and vitamin D from different endocrine organs which ultimately causes impairment of adequate bone mass achievement.	Iron	22-26	insulin	Homo sapiens	81-88
35383762-3	2022	Transfusion dependent iron over load cause decrease secretion of growth hormone, insulin, thyroid hormone, parathyroid hormone, sex hormone and vitamin D from different endocrine organs which ultimately causes impairment of adequate bone mass achievement.	Iron	22-26	parathyroid hormone	Homo sapiens	107-126
35407912-0	2022	Switching Diagram of Core-Shell FePt/Fe Nanocomposites for Bit Patterned Media.	Iron	37-39	signal regulatory protein alpha	Homo sapiens	59-62
35182697-8	2022	The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4.	Iron	111-115	ferritin heavy chain 1	Rattus norvegicus	173-193
35182697-8	2022	The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4.	Iron	111-115	ferritin heavy chain 1	Rattus norvegicus	195-198
35122944-0	2022	Vitamin E prevents lipid peroxidation and iron accumulation in PLA2G6-Associated Neurodegeneration.	Iron	42-46	phospholipase A2 group VI	Homo sapiens	63-69
35122944-1	2022	BACKGROUND: PLA2G6-Associated Neurodegeneration (PLAN) is a rare neurodegenerative disease with autosomal recessive inheritance, which belongs to the NBIA (Neurodegeneration with Brain Iron Accumulation) group.	Iron	185-189	phospholipase A2 group VI	Homo sapiens	12-18
35464670-4	2022	Herein, we report estrogen receptor-positive leptomeningeal metastasis clearly demonstrated by 16alpha-(18F)-fluoro-17beta-estradiol ((18F)-FES) positron emission tomography/computed tomography (PET/CT) in a patient with metastatic breast cancer.	Iron	139-143	estrogen receptor 1	Homo sapiens	18-35
35089637-7	2022	Knockdown of PCBP2 but not PCBP1 significantly decreased both TfR1 and FTH expression in MM cells with inhibition of proliferation, indicating stagnation of intracellular iron transport.	Iron	171-175	ferritin heavy chain 1	Rattus norvegicus	71-74
35346040-9	2022	Furthermore, in mnb1 mutants, the transcription level of the Fe uptake- and translocation-related genes, FIT, IRT1, FRO2, ZIF, FRD3, NAS4, PYE and MYB72, were considerably elevated during Fe-deficiency stress, resulting in enhanced Fe uptake and translocation, thereby increasing Fe accumulation.	Iron	61-63	MATE efflux family protein	Arabidopsis thaliana	127-131
35331277-7	2022	L-VGCCs and RyR calcium channels were also involved in promoting the excess iron influx and triggering ER stress response, respectively, which both exert excessive ROS generation and result in the ferroptosis and inflammation in BV2 cells.	Iron	76-80	ryanodine receptor 1, skeletal muscle	Mus musculus	12-15
35407065-2	2022	Spirulina incorporation led to development of green color pasta with nutritional and functional fortification resulting in increase in its protein, total phenols, flavonoids, iron and calcium content by up to 77.47%, 76.62%, 162.88%, 296.99% and 57.27%, respectively, without causing detrimental changes to the textural and sensory attributes.	Iron	175-179	solute carrier family 45 member 1	Homo sapiens	58-63
35447901-11	2022	In conclusion, our results provide in vitro evidence that SPH potentiates the growth inhibitory effect of bicalutamide on prostate cancer cells by modulating iron homeostasis mechanisms.	Iron	158-162	surfactant associated 3	Homo sapiens	58-61
35447901-5	2022	A bioactive peptide-rich salmon protein hydrolysate (SPH) has previously been demonstrated to modulate iron homeostatic mechanisms.	Iron	103-107	surfactant associated 3	Homo sapiens	53-56
34982827-7	2022	We show transcript expression of LcytB and Steap3 is decreased in macrophages exposed to Escherichia coli pathogen UTI89 supporting a role for these reductases in regulating iron availability for pathogens.	Iron	174-178	cytochrome b561 family, member A3	Mus musculus	33-38
35415365-4	2022	It was confirmed that the small amounts of alpha-Fe2O3 can availably facilitate exfoliation of bulk SPI, resulting in a transformation of SPI from bulk to 2D layered composite that illustrates tight interface through the coordination Fe-N bond and an all-solid-state direct Z-scheme junction.	Iron	234-236	chromogranin A	Homo sapiens	100-103
35415365-4	2022	It was confirmed that the small amounts of alpha-Fe2O3 can availably facilitate exfoliation of bulk SPI, resulting in a transformation of SPI from bulk to 2D layered composite that illustrates tight interface through the coordination Fe-N bond and an all-solid-state direct Z-scheme junction.	Iron	234-236	chromogranin A	Homo sapiens	138-141
34982827-0	2022	Lysosomal iron recycling in mouse macrophages is dependent upon both reductases LcytB and Steap3.	Iron	10-14	cytochrome b561 family, member A3	Mus musculus	80-85
34982827-7	2022	We show transcript expression of LcytB and Steap3 is decreased in macrophages exposed to Escherichia coli pathogen UTI89 supporting a role for these reductases in regulating iron availability for pathogens.	Iron	174-178	STEAP3 metalloreductase	Equus caballus	43-49
34982827-9	2022	Together, our findings reveal an important role for both LcytB and Steap3 in macrophage iron recycling and suggest that limiting iron recycling by decreasing expression of endolysosomal reductases is an innate immune response to protect against pathogen proliferation and sepsis.	Iron	88-92	cytochrome b561 family, member A3	Mus musculus	57-62
34982827-3	2022	Here we report that the lysosomal reductase Cyb561a3 (LcytB) and the endosomal reductase Six-transmembrane epithelial antigen of the prostate 3 (Steap3) act as lysosomal ferrireductases in the mouse macrophage cell line RAW264.7 converting Fe3+ to Fe2+ for iron recycling.	Iron	257-261	cytochrome b561 family, member A3	Mus musculus	44-52
34982827-3	2022	Here we report that the lysosomal reductase Cyb561a3 (LcytB) and the endosomal reductase Six-transmembrane epithelial antigen of the prostate 3 (Steap3) act as lysosomal ferrireductases in the mouse macrophage cell line RAW264.7 converting Fe3+ to Fe2+ for iron recycling.	Iron	257-261	cytochrome b561 family, member A3	Mus musculus	54-59
34982827-9	2022	Together, our findings reveal an important role for both LcytB and Steap3 in macrophage iron recycling and suggest that limiting iron recycling by decreasing expression of endolysosomal reductases is an innate immune response to protect against pathogen proliferation and sepsis.	Iron	88-92	STEAP3 metalloreductase	Equus caballus	67-73
34982827-4	2022	We determined that when lysosomes were loaded with horse cationic ferritin, reductions or loss of LcytB or Steap3 using CrispR/Cas9-mediated knockout technology resulted in decreased lysosomal iron export.	Iron	193-197	STEAP3 metalloreductase	Equus caballus	107-113
34982827-9	2022	Together, our findings reveal an important role for both LcytB and Steap3 in macrophage iron recycling and suggest that limiting iron recycling by decreasing expression of endolysosomal reductases is an innate immune response to protect against pathogen proliferation and sepsis.	Iron	129-133	cytochrome b561 family, member A3	Mus musculus	57-62
34982827-9	2022	Together, our findings reveal an important role for both LcytB and Steap3 in macrophage iron recycling and suggest that limiting iron recycling by decreasing expression of endolysosomal reductases is an innate immune response to protect against pathogen proliferation and sepsis.	Iron	129-133	STEAP3 metalloreductase	Equus caballus	67-73
35402880-0	2022	Origin and mobility of Iron Age Gaulish groups in present-day France revealed through archaeogenomics.	Iron	23-27	renin binding protein	Homo sapiens	28-31
35391749-3	2022	Amyloid precursor protein (APP) and tau protein, both of which are related to the AD pathogenesis, are associated with brain iron metabolism.	Iron	125-129	amyloid beta precursor protein	Homo sapiens	0-25
35391749-5	2022	Amyloid beta (Abeta) and hyperphosphorylated tau, two pathological hallmarks of AD, can also promote iron deposition in the brain, forming a vicious cycle of AD development-iron deposition.	Iron	101-105	amyloid beta precursor protein	Homo sapiens	0-12
35391749-5	2022	Amyloid beta (Abeta) and hyperphosphorylated tau, two pathological hallmarks of AD, can also promote iron deposition in the brain, forming a vicious cycle of AD development-iron deposition.	Iron	173-177	amyloid beta precursor protein	Homo sapiens	0-12
35191669-6	2022	Initially, d-Pen reacts with native catalase and/or iron metal ions, used to mimic non-heme iron overload observed in long-term treated WD patients, to generate thiyl radicals.	Iron	92-96	catalase	Homo sapiens	36-44
35303762-6	2022	KEY RESULTS: As expected, Nrf2 deletion induced ferroptosis-related protein expression and iron accumulation in vivo, further aggravating CI-AKI.	Iron	91-95	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
35402880-3	2022	The 49 acquired genomes permitted us to highlight an absence of discontinuity between Bronze Age and Iron Age groups in France, lending support to a cultural transition linked to progressive local economic changes rather than to a massive influx of allochthone groups.	Iron	101-105	renin binding protein	Homo sapiens	106-109
35402880-6	2022	Thus, the results globally support a common genomic legacy for the Iron Age population of modern-day France that could be linked to recurrent gene flow between culturally differentiated communities.	Iron	67-71	renin binding protein	Homo sapiens	72-75
35402880-1	2022	The Iron Age period occupies an important place in French history because the Gauls are regularly presented as the direct ancestors of the extant French population.	Iron	4-8	renin binding protein	Homo sapiens	9-12
35402880-2	2022	We documented here the genomic diversity of Iron Age communities originating from six French regions.	Iron	44-48	renin binding protein	Homo sapiens	49-52
35411219-8	2022	Blocking transferrin-mediated iron import or recycling of iron-containing storage proteins (i.e., ferritin) also attenuates ferroptosis, consistent with the iron-dependent nature of this process.	Iron	30-34	transferrin	Homo sapiens	9-20
35411219-8	2022	Blocking transferrin-mediated iron import or recycling of iron-containing storage proteins (i.e., ferritin) also attenuates ferroptosis, consistent with the iron-dependent nature of this process.	Iron	58-62	transferrin	Homo sapiens	9-20
35411219-8	2022	Blocking transferrin-mediated iron import or recycling of iron-containing storage proteins (i.e., ferritin) also attenuates ferroptosis, consistent with the iron-dependent nature of this process.	Iron	157-161	transferrin	Homo sapiens	9-20
35122997-7	2022	Notably, elabela strikingly alleviated Ang II-induced upregulation of iron levels and lipid peroxidation in hypertensive mice by suppressing cardiac interleukin-6 (IL-6)/STAT3 signaling and activating the xCT/glutathione peroxidase (GPX4) signaling.	Iron	70-74	interleukin 6	Mus musculus	164-168
35273327-6	2022	CAT activity was improved in response to Se, nano-Fe, and graphene oxide (50 g kg-1).	Iron	50-52	catalase	Homo sapiens	0-3
35335148-2	2022	However, in several diseases and clinical conditions, hazardous non-transferrin-bound iron (NTBI) species occur.	Iron	86-90	transferrin	Homo sapiens	68-79
35335148-8	2022	The currently accepted hypotheses suggest that NTBI is mostly iron bound to citric acid and iron bound to serum albumin, but the chemistry of this system remains fuzzy.	Iron	62-66	albumin	Homo sapiens	106-119
35335148-8	2022	The currently accepted hypotheses suggest that NTBI is mostly iron bound to citric acid and iron bound to serum albumin, but the chemistry of this system remains fuzzy.	Iron	92-96	albumin	Homo sapiens	106-119
35327400-2	2022	Analysis of the effect that human serum, human serum albumin, and human pleural fluid had on growing Acinetobacter baumannii showed that genes related to iron uptake were down-regulated.	Iron	154-158	albumin	Homo sapiens	47-60
35327400-5	2022	These results correlate with increased expression levels of beta-lactamase genes and the down-regulation of iron uptake-related genes in cultures containing human serum, human serum albumin, or human pleural fluid.	Iron	108-112	albumin	Homo sapiens	176-189
34392292-0	2022	18F-PSMA-1007 Uptake in Paget Disease of the Bone: An "Iron Man" Sign.	Iron	55-59	folate hydrolase 1	Homo sapiens	4-8
34392292-4	2022	18F-PSMA PET/CT shows intense tracer uptake in the frontal bone appearing like an "Iron Man" sign.	Iron	83-87	folate hydrolase 1	Homo sapiens	4-8
35335148-0	2022	The (Bio)Chemistry of Non-Transferrin-Bound Iron.	Iron	44-48	transferrin	Homo sapiens	26-37
35335148-1	2022	In healthy individuals, virtually all blood plasma iron is bound by transferrin.	Iron	51-55	transferrin	Homo sapiens	68-79
35269062-6	2022	In addition the (Fe/Pd)n coatings formed an L10 phase with a magnetic face-centered tetragonal-ordered structure after heat treatment.	Iron	17-19	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	44-47
35038358-5	2022	Consistently, the rescue effects of dZIP13 OE or Tsf1 RNAi on Pink1 RNAi can be inhibited by decreasing the iron levels in mitochondria through mitoferrin (dmfrn) RNAi.	Iron	108-112	mitoferrin	Drosophila melanogaster	144-154
35038358-6	2022	This study suggests that dZIP13, Tsf1 and dmfrn might act independently of parkin in a parallel pathway downstream of Pink1 by modulating respiration and indicates that manipulation of iron levels in mitochondria may provide a novel therapeutic strategy for PD associated with Pink1.	Iron	185-189	parkin	Drosophila melanogaster	75-81
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	parkin	Drosophila melanogaster	82-88
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	parkin	Drosophila melanogaster	476-482
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	327-331	parkin	Drosophila melanogaster	82-88
35532650-1	2022	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal-recessive disease characterized by iron accumulation in the brain due to PANK2 gene mutation.	Iron	107-111	pantothenate kinase 2	Homo sapiens	0-48
35532650-1	2022	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal-recessive disease characterized by iron accumulation in the brain due to PANK2 gene mutation.	Iron	107-111	pantothenate kinase 2	Homo sapiens	50-54
35532650-1	2022	Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal-recessive disease characterized by iron accumulation in the brain due to PANK2 gene mutation.	Iron	107-111	pantothenate kinase 2	Homo sapiens	145-150
35295653-7	2022	Compared with no TNF-alpha stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-alpha; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-alpha treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 microg/mL treating MAECs.	Iron	180-182	tumor necrosis factor	Mus musculus	160-169
35295653-7	2022	Compared with no TNF-alpha stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-alpha; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-alpha treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 microg/mL treating MAECs.	Iron	180-182	tumor necrosis factor	Mus musculus	264-273
35295653-7	2022	Compared with no TNF-alpha stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-alpha; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-alpha treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 microg/mL treating MAECs.	Iron	294-296	tumor necrosis factor	Mus musculus	160-169
35295653-7	2022	Compared with no TNF-alpha stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-alpha; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-alpha treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 microg/mL treating MAECs.	Iron	341-343	tumor necrosis factor	Mus musculus	160-169
35080370-5	2022	CFp NPs degrade under the mildly acidic conditions of TME, self-supply H2O2, and the released Cu and Fe ions, with their larger portions at lower oxidation states, cooperatively facilitate hydroxyl radical production through a highly efficient catalytic loop to achieve an excellent tumor therapeutic efficacy.	Iron	101-103	complement factor properdin	Homo sapiens	0-3
35217637-0	2022	Massive iron accumulation in PKAN-derived neurons and astrocytes: light on the human pathological phenotype.	Iron	8-12	pantothenate kinase 2	Homo sapiens	29-33
35217637-7	2022	Within this mixed population, we detected iron deposition in both PKAN cell types, however, the viability of PKAN GABAergic neurons was strongly affected.	Iron	42-46	pantothenate kinase 2	Homo sapiens	66-70
35217637-10	2022	The analysis of these PKAN astrocytes indicated alterations in iron metabolism, mitochondrial morphology, respiratory activity, and oxidative status.	Iron	63-67	pantothenate kinase 2	Homo sapiens	22-26
35269771-1	2022	Fractalkine (CX3CL1) acts as a chemokine as well as a regulator of iron metabolism.	Iron	67-71	C-X3-C motif chemokine ligand 1	Homo sapiens	0-11
35269771-1	2022	Fractalkine (CX3CL1) acts as a chemokine as well as a regulator of iron metabolism.	Iron	67-71	C-X3-C motif chemokine ligand 1	Homo sapiens	13-19
35269771-6	2022	The results showed that fractalkine treatment alone did not affect the pro-inflammatory cytokine secretion, but it was proposed to act as a regulator of the iron metabolism of THP-1 cells.	Iron	157-161	C-X3-C motif chemokine ligand 1	Homo sapiens	24-35
35269771-7	2022	In the case of two different LPS and one type of LTA with fractalkine co-treatments, fractalkine was able to alter the levels of signalling proteins (NFkappaB, PSTAT3, Nrf2/Keap-1) regulating the expression of pro-inflammatory cytokines as well as hepcidin, and the iron storage and utilization of the THP-1 cells.	Iron	266-270	C-X3-C motif chemokine ligand 1	Homo sapiens	58-69
35269771-7	2022	In the case of two different LPS and one type of LTA with fractalkine co-treatments, fractalkine was able to alter the levels of signalling proteins (NFkappaB, PSTAT3, Nrf2/Keap-1) regulating the expression of pro-inflammatory cytokines as well as hepcidin, and the iron storage and utilization of the THP-1 cells.	Iron	266-270	C-X3-C motif chemokine ligand 1	Homo sapiens	85-96
35045311-0	2022	Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway.	Iron	40-42	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
35191282-2	2022	The enzyme myeloperoxidase (MPO) is a relevant biomarker for infection and inflammation events assessment; however its direct electrochemical quantification is hindered by the limited accessibility to the iron atom in its active center.	Iron	205-209	myeloperoxidase	Homo sapiens	11-26
35191282-2	2022	The enzyme myeloperoxidase (MPO) is a relevant biomarker for infection and inflammation events assessment; however its direct electrochemical quantification is hindered by the limited accessibility to the iron atom in its active center.	Iron	205-209	myeloperoxidase	Homo sapiens	28-31
35045311-5	2022	Dietary iron overload also decreased mRNA and protein expression levels of glutathione peroxidase 4 (GPX4) and cystine-glutamate antiporter (SLC7A11), and increased mRNA and protein expression of acyl-CoA synthetase long-chain family member 4 (ACSL4), which are all markers of ferroptosis.	Iron	8-12	acyl-CoA synthetase long chain family member 4	Homo sapiens	196-242
35045311-5	2022	Dietary iron overload also decreased mRNA and protein expression levels of glutathione peroxidase 4 (GPX4) and cystine-glutamate antiporter (SLC7A11), and increased mRNA and protein expression of acyl-CoA synthetase long-chain family member 4 (ACSL4), which are all markers of ferroptosis.	Iron	8-12	acyl-CoA synthetase long chain family member 4	Homo sapiens	244-249
35045311-9	2022	Experiments with HEK293T cells revealed that Fe-induced ferroptosis involved direct inhibition of NRF2 binding to antioxidant response elements (AREs) within the promoters of the gpx4 and slc7a11 genes, which in turn induced transcriptional silencing.	Iron	45-47	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
35204817-6	2022	Circulating miR-199a-5p and miR-144 were associated with hemolytic biomarkers such as LDH, indirect bilirubin, AST, GGT, iron, ferritin, RBC, hemoglobin, and NOm, in addition to association with impaired clinical profile of SLU.	Iron	121-125	microRNA 144	Homo sapiens	28-35
35204826-1	2022	Pantothenate kinase-associated neurodegeneration (PKAN) is a progressive neurodegenerative disease caused by mutations in the pantothenate kinase 2 (PANK2) gene and associated with iron deposition in basal ganglia.	Iron	181-185	pantothenate kinase 2	Homo sapiens	0-48
35204826-1	2022	Pantothenate kinase-associated neurodegeneration (PKAN) is a progressive neurodegenerative disease caused by mutations in the pantothenate kinase 2 (PANK2) gene and associated with iron deposition in basal ganglia.	Iron	181-185	pantothenate kinase 2	Homo sapiens	50-54
35204826-1	2022	Pantothenate kinase-associated neurodegeneration (PKAN) is a progressive neurodegenerative disease caused by mutations in the pantothenate kinase 2 (PANK2) gene and associated with iron deposition in basal ganglia.	Iron	181-185	pantothenate kinase 2	Homo sapiens	126-147
35204826-1	2022	Pantothenate kinase-associated neurodegeneration (PKAN) is a progressive neurodegenerative disease caused by mutations in the pantothenate kinase 2 (PANK2) gene and associated with iron deposition in basal ganglia.	Iron	181-185	pantothenate kinase 2	Homo sapiens	149-154
35204826-9	2022	This finding hints at the importance of carboxylate metabolism in PKAN pathology with potential links to reduced cytoplasmic acetyl-CoA levels in neurons and to aberrant brain iron regulation.	Iron	176-180	pantothenate kinase 2	Homo sapiens	66-70
35172141-7	2022	These data suggest that IL-6-induced CISR leads to toxic neuronal iron accumulation, contributing to synuclein-induced neurodegeneration.	Iron	66-70	interleukin 6	Mus musculus	24-28
35167013-4	2022	These enzymes function to ensure the efficient oxidation of iron so that it can be effectively released from tissues via the iron export protein ferroportin and subsequently bound to the iron carrier protein transferrin in the blood.	Iron	60-64	transferrin	Homo sapiens	208-219
35167013-4	2022	These enzymes function to ensure the efficient oxidation of iron so that it can be effectively released from tissues via the iron export protein ferroportin and subsequently bound to the iron carrier protein transferrin in the blood.	Iron	125-129	transferrin	Homo sapiens	208-219
35167013-4	2022	These enzymes function to ensure the efficient oxidation of iron so that it can be effectively released from tissues via the iron export protein ferroportin and subsequently bound to the iron carrier protein transferrin in the blood.	Iron	187-191	transferrin	Homo sapiens	208-219
35172141-0	2022	Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological alpha-synuclein.	Iron	38-42	interleukin 6	Homo sapiens	0-13
35172141-4	2022	IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a pathway we term the cellular iron sequestration response, or CISR.	Iron	71-75	interleukin 6	Homo sapiens	0-4
35172141-4	2022	IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a pathway we term the cellular iron sequestration response, or CISR.	Iron	145-149	interleukin 6	Homo sapiens	0-4
35172141-4	2022	IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a pathway we term the cellular iron sequestration response, or CISR.	Iron	192-196	interleukin 6	Homo sapiens	0-4
35163840-0	2022	Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia.	Iron	68-72	transferrin	Homo sapiens	0-11
35143099-6	2022	Signal transducer and activator of transcription 3 (STAT3)/nuclear factor-kappaB (NF-kappaB) signaling is involved in the protective function of rifaximin against LPS-induced iron deposition.	Iron	175-179	signal transducer and activator of transcription 3	Homo sapiens	0-50
35143099-6	2022	Signal transducer and activator of transcription 3 (STAT3)/nuclear factor-kappaB (NF-kappaB) signaling is involved in the protective function of rifaximin against LPS-induced iron deposition.	Iron	175-179	signal transducer and activator of transcription 3	Homo sapiens	52-57
35143099-6	2022	Signal transducer and activator of transcription 3 (STAT3)/nuclear factor-kappaB (NF-kappaB) signaling is involved in the protective function of rifaximin against LPS-induced iron deposition.	Iron	175-179	nuclear factor kappa B subunit 1	Homo sapiens	82-91
35138377-7	2022	Binding of the iron carriers to the outer membrane receptors elicits proteolysis of the anti-sigma factor by two different proteases, Prc in the periplasm and RseP in the cytoplasmic membrane, inactivates the anti-sigma function or results in the generation of an N-terminal peptide of ~50 residues with pro-sigma activity yielding an active extracytoplasmic function (ECF) sigma factor.	Iron	15-19	PPARG related coactivator 1	Homo sapiens	134-137
35163840-0	2022	Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia.	Iron	68-72	transmembrane serine protease 6	Homo sapiens	52-59
35211082-9	2022	However, pallidal signal changes were associated with age-related accelerated iron depletion and variability and having both MCP and pallidal signs further increased iron variability in the globus pallidus.	Iron	166-170	CD46 molecule	Homo sapiens	125-128
35163840-0	2022	Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia.	Iron	84-88	transferrin	Homo sapiens	0-11
35163840-0	2022	Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia.	Iron	84-88	transmembrane serine protease 6	Homo sapiens	52-59
35211082-10	2022	Conclusions: Only the MCP sign, not pallidal abnormalities, revealed independent associations with motor and cognitive impairment; however, the occurrence of combined MCP and pallidal T2-abnormalities may present a risk for greater cognitive impairment and increased iron variability in the globus pallidus.	Iron	267-271	CD46 molecule	Homo sapiens	22-25
35163840-1	2022	Pathogenic TMPRSS6 variants impairing matriptase-2 function result in inappropriately high hepcidin levels relative to body iron status, leading to iron refractory iron deficiency anemia (IRIDA).	Iron	148-152	transmembrane serine protease 6	Homo sapiens	11-18
35211082-10	2022	Conclusions: Only the MCP sign, not pallidal abnormalities, revealed independent associations with motor and cognitive impairment; however, the occurrence of combined MCP and pallidal T2-abnormalities may present a risk for greater cognitive impairment and increased iron variability in the globus pallidus.	Iron	267-271	CD46 molecule	Homo sapiens	167-170
35101982-3	2022	Here, we present a metal-organic framework (MOF)-derived cobalt-doped Fe@Fe2O3 (Co-Fe@Fe2O3) NO3 -RR catalyst for electrochemical energy production.	Iron	70-72	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
35163840-1	2022	Pathogenic TMPRSS6 variants impairing matriptase-2 function result in inappropriately high hepcidin levels relative to body iron status, leading to iron refractory iron deficiency anemia (IRIDA).	Iron	148-152	transmembrane serine protease 6	Homo sapiens	38-50
35141461-3	2022	Like the yeast homologue, CrATX1 accumulates in iron-deficient cells (but is not impacted by other metal-deficiencies).	Iron	48-52	uncharacterized protein	Chlamydomonas reinhardtii	26-32
35154576-4	2022	Treatment of ferrostatin-1 (Ferr-1) and 3-methyladenine (3-MA) decreased iron deposition in IL-13-induced BEAS-2B cells and lung tissues of asthma mice, opposite to that in bronchoalveolar lavage fluid (BALF).	Iron	73-77	interleukin 13	Homo sapiens	92-97
35115522-4	2022	In addition, we observed liquid immiscibility in Fe-S-H(+-Si,O,C) at least to 118 GPa, suggesting that it can occur in the Earth"s topmost outer core and form a low-velocity layer below the core-mantle boundary.	Iron	49-51	glycophorin A (MNS blood group)	Homo sapiens	82-85
35204767-6	2022	Interestingly, iron overloading suppressed IRP1 expression, thus downregulating DMT1 and upregulating FPN1 levels in these microglial cells.	Iron	15-19	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	102-106
35204767-7	2022	On the contrary, iron deficiency activated IRP1, leading to increased expression of DMT1 and decreased expression of FPN1-which indicates that activated IRP1 induces iron overloading in 6-OHDA-treated microglia, but not iron overloading modulates the expression of IRP1.	Iron	166-170	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	117-121
35204767-8	2022	Taken together, our data suggest that 6-OHDA can regulate the expression of DMT1 and FPN1 by activating IRP1 and inhibiting hepcidin release, thus leading to abnormal iron sequestration in microglia.	Iron	167-171	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	85-89
35224489-13	2022	Moreover, greater density of iron-positive cells in the cortex was associated with lower amyloid beta plaque area and a trend towards increased post-vaccination antibody titres.	Iron	29-33	amyloid beta precursor protein	Homo sapiens	89-101
35050568-3	2022	However, how the sialylation pattern affects the AD-associated, transferrin-assisted iron/Abeta cellular uptake process remains largely ill-defined.	Iron	85-89	transferrin	Homo sapiens	64-75
35050568-3	2022	However, how the sialylation pattern affects the AD-associated, transferrin-assisted iron/Abeta cellular uptake process remains largely ill-defined.	Iron	85-89	amyloid beta precursor protein	Homo sapiens	90-95
35050568-6	2022	Cell viability experiments suggest that Neu5Gc replacement enhances the transferrin-assisted, iron loading-associated Abeta cytotoxicity.	Iron	94-98	transferrin	Homo sapiens	72-83
34171864-9	2022	Transferrin saturation and serum ferritin were significantly increased in the iron group than in the control group (P < 0.001).	Iron	78-82	transferrin	Homo sapiens	0-11
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	101-105	CD40 ligand	Homo sapiens	233-238
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	101-105	CD4 molecule	Homo sapiens	251-254
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	122-126	CD40 ligand	Homo sapiens	233-238
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	122-126	CD4 molecule	Homo sapiens	251-254
35218933-3	2022	Thus, in response to iron deficiency, transcription factors Aft1 and Aft2 activate the expression of genes implicated in iron acquisition and mobilization, whereas two mRNA-binding proteins, Cth1 and Cth2, posttranscriptionally control iron metabolism.	Iron	121-125	Aft2p	Saccharomyces cerevisiae S288C	69-73
35107212-4	2022	NRF2 and BACH1 inhibit and promote ferroptosis, respectively, by activating or suppressing the expression of genes in the major regulatory pathways of ferroptosis: intracellular labile iron metabolism, the GSH (glutathione) -GPX4 (glutathione peroxidase 4) pathway, and the FSP1 (ferroptosis suppressor protein 1)-CoQ (coenzyme Q) pathway.	Iron	185-189	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34998864-5	2022	Oral iron supplementation (20.56 mg elemental Fe/kg bw) to aloin-treated rats normalized red blood corpuscles count, hemoglobin concentration, and serum levels of total iron binding capacity and saturated transferrin, as well as hepatic iron content, hepcidin level, and mRNA expression of ferritin heavy chain (Ferr-H) and transferrin receptor-1 (TfR-1) genes.	Iron	5-9	transferrin	Rattus norvegicus	205-216
35107212-4	2022	NRF2 and BACH1 inhibit and promote ferroptosis, respectively, by activating or suppressing the expression of genes in the major regulatory pathways of ferroptosis: intracellular labile iron metabolism, the GSH (glutathione) -GPX4 (glutathione peroxidase 4) pathway, and the FSP1 (ferroptosis suppressor protein 1)-CoQ (coenzyme Q) pathway.	Iron	185-189	BTB domain and CNC homolog 1	Homo sapiens	9-14
35107212-4	2022	NRF2 and BACH1 inhibit and promote ferroptosis, respectively, by activating or suppressing the expression of genes in the major regulatory pathways of ferroptosis: intracellular labile iron metabolism, the GSH (glutathione) -GPX4 (glutathione peroxidase 4) pathway, and the FSP1 (ferroptosis suppressor protein 1)-CoQ (coenzyme Q) pathway.	Iron	185-189	atlastin GTPase 1	Homo sapiens	274-278
35107212-4	2022	NRF2 and BACH1 inhibit and promote ferroptosis, respectively, by activating or suppressing the expression of genes in the major regulatory pathways of ferroptosis: intracellular labile iron metabolism, the GSH (glutathione) -GPX4 (glutathione peroxidase 4) pathway, and the FSP1 (ferroptosis suppressor protein 1)-CoQ (coenzyme Q) pathway.	Iron	185-189	atlastin GTPase 1	Homo sapiens	280-312
34998864-8	2022	On other hand, oral iron supplementation to rats treated with doxorubicin (15 mg/kg bw) lessened the increase in the spleen iron content concomitantly with hepatic hepcidin level, rebound hepatic iron content to normal level, and by contrast augmented serum levels of iron and transferrin saturation.	Iron	20-24	hepcidin antimicrobial peptide	Rattus norvegicus	164-172
34998864-8	2022	On other hand, oral iron supplementation to rats treated with doxorubicin (15 mg/kg bw) lessened the increase in the spleen iron content concomitantly with hepatic hepcidin level, rebound hepatic iron content to normal level, and by contrast augmented serum levels of iron and transferrin saturation.	Iron	20-24	transferrin	Rattus norvegicus	277-288
34998864-5	2022	Oral iron supplementation (20.56 mg elemental Fe/kg bw) to aloin-treated rats normalized red blood corpuscles count, hemoglobin concentration, and serum levels of total iron binding capacity and saturated transferrin, as well as hepatic iron content, hepcidin level, and mRNA expression of ferritin heavy chain (Ferr-H) and transferrin receptor-1 (TfR-1) genes.	Iron	46-48	transferrin	Rattus norvegicus	205-216
35144194-1	2022	In order to improve iron chelating ability and retain the activity of functional peptide, corn peptide was chelated with iron to form corn ACE inhibitory peptide-ferrous chelate (CP-Fe) treated by dual-frequency ultrasound.	Iron	20-24	angiotensin I converting enzyme	Homo sapiens	139-142
35068370-1	2022	Pantothenase kinase-associated neurodegeneration (PKAN) is characterized by an abnormal accumulation of iron in basal ganglia and progressing varied extrapyramidal clinical symptoms.	Iron	104-108	pantothenate kinase 2	Homo sapiens	0-48
35068370-1	2022	Pantothenase kinase-associated neurodegeneration (PKAN) is characterized by an abnormal accumulation of iron in basal ganglia and progressing varied extrapyramidal clinical symptoms.	Iron	104-108	pantothenate kinase 2	Homo sapiens	50-54
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	84-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	190-222
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	140-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	190-222
34320783-8	2022	The results suggest that the E1 enzyme UBA6 and the adaptor protein NDFIP1 are involved in iron homeostasis by regulating the degradation of ferroportin.	Iron	91-95	ubiquitin-like modifier activating enzyme 6	Mus musculus	39-43
35144194-1	2022	In order to improve iron chelating ability and retain the activity of functional peptide, corn peptide was chelated with iron to form corn ACE inhibitory peptide-ferrous chelate (CP-Fe) treated by dual-frequency ultrasound.	Iron	121-125	angiotensin I converting enzyme	Homo sapiens	139-142
35144194-9	2022	This study provides a novel synthesis method of the iron-chelating corn ACE inhibitory peptide, which is promising to be applied as iron supplements with high efficiency, bioactivity, and stability.	Iron	52-56	angiotensin I converting enzyme	Homo sapiens	72-75
35144194-9	2022	This study provides a novel synthesis method of the iron-chelating corn ACE inhibitory peptide, which is promising to be applied as iron supplements with high efficiency, bioactivity, and stability.	Iron	132-136	angiotensin I converting enzyme	Homo sapiens	72-75
35204145-1	2022	The evolutionary conserved non-heme Fe-containing protein pirin has been implicated as an important factor in cell proliferation, migration, invasion, and tumour progression of melanoma, breast, lung, cervical, prostate, and oral cancers.	Iron	36-38	pirin	Homo sapiens	58-63
35207503-6	2022	RNA-seq analyses revealed that the Fe nutrition-related genes were upregulated in bts-1 mutants, especially under Zn stress conditions.	Iron	35-37	bladder tumor susceptibility 1	Homo sapiens	82-87
35207503-7	2022	Therefore, the bts-1 mutants had a greater Fe concentration and a higher Fe/Zn ratio than the wild-type plants exposed to Zn toxicity.	Iron	43-45	bladder tumor susceptibility 1	Homo sapiens	15-20
35207503-7	2022	Therefore, the bts-1 mutants had a greater Fe concentration and a higher Fe/Zn ratio than the wild-type plants exposed to Zn toxicity.	Iron	73-75	bladder tumor susceptibility 1	Homo sapiens	15-20
35207503-8	2022	Further study showed that the differences in Zn tolerance between bts-1 and wild-type plants were minimized by eliminating Fe or supplementing excessive Fe in the growth medium.	Iron	123-125	bladder tumor susceptibility 1	Homo sapiens	66-71
35207503-8	2022	Further study showed that the differences in Zn tolerance between bts-1 and wild-type plants were minimized by eliminating Fe or supplementing excessive Fe in the growth medium.	Iron	153-155	bladder tumor susceptibility 1	Homo sapiens	66-71
35018928-3	2022	The double back propagation artificial neural network (DBP-ANN) proposed in this paper provides a solution to improve the accuracy of LIBS in determining the TFe content of branded iron ores, which is a combination of pattern recognition and regression analysis based on BP-ANN.	Iron	181-185	D-box binding PAR bZIP transcription factor	Homo sapiens	55-58
35091578-4	2022	Further study revealed that, compared with nitrate, ammonium led to excess iron accumulation in the apoplast of phloem in an LPR2-dependent manner.	Iron	75-79	Cupredoxin superfamily protein	Arabidopsis thaliana	125-129
35018928-10	2022	The results showed that LIBS combined with DBP-ANN has the potential to achieve rapid and accurate analysis of the TFe content of branded iron ores.	Iron	138-142	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46
35082221-1	2022	PURPOSE: While amyloid-beta deposition in the cerebral cortex for Alzheimer"s disease (AD) is often evaluated by amyloid positron emission tomography (PET), amyloid-beta-related iron can be detected using phase difference enhanced (PADRE) imaging; however, no study has validated the association between PADRE imaging and amyloid PET.	Iron	178-182	amyloid beta precursor protein	Homo sapiens	15-27
35082221-1	2022	PURPOSE: While amyloid-beta deposition in the cerebral cortex for Alzheimer"s disease (AD) is often evaluated by amyloid positron emission tomography (PET), amyloid-beta-related iron can be detected using phase difference enhanced (PADRE) imaging; however, no study has validated the association between PADRE imaging and amyloid PET.	Iron	178-182	amyloid beta precursor protein	Homo sapiens	157-169
35075227-7	2022	Kidney iron loading, predominantly in distal tubules, increased in time, along with urinary kidney injury molecule-1 and 24p3 concentration, as well as kidney mRNA expression of Interleukin-6 (Il-6) and Heme oxygenase-1 (Ho-1).	Iron	7-11	interleukin 6	Mus musculus	193-197
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-126
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	177-181
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	222-226
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	344-348
35075211-4	2022	M-CSF blockade enhanced inflammatory cytokine secretion, further increased systemic neutrophil counts, and led to tissue iron sequestration that was dependent, in part, on augmented IL-6 secretion which induced hepcidin.	Iron	121-125	interleukin 6	Mus musculus	182-186
35077680-4	2022	Mechanistically, Notch acts in an unconventional manner to regulate RET by interacting with specific RC-I proteins containing electron-transporting Fe-S clusters and NAD(H)-binding sites.	Iron	148-152	Notch	Drosophila melanogaster	17-22
35075227-7	2022	Kidney iron loading, predominantly in distal tubules, increased in time, along with urinary kidney injury molecule-1 and 24p3 concentration, as well as kidney mRNA expression of Interleukin-6 (Il-6) and Heme oxygenase-1 (Ho-1).	Iron	7-11	heme oxygenase 1	Mus musculus	221-225
35075211-5	2022	Deleterious effects of post burn M-CSF blockade were associated with arrest of an iron recycling gene expression signature in the liver and spleen that included Spi-C transcription factor and heme oxygenase-1, which promote heme metabolism and confer a non-inflammatory tone in macrophages.	Iron	82-86	heme oxygenase 1	Mus musculus	192-208
34614145-1	2022	The hormone erythroferrone (ERFE) is produced by erythroid cells in response to hemorrhage, hypoxia or other erythropoietic stimuli, and suppresses the hepatic production of the iron-regulatory hormone hepcidin, thereby mobilizing iron for erythropoiesis.	Iron	178-182	erythroferrone	Mus musculus	28-32
35051929-4	2022	METHODS: Relationship of iron-related factors with platelet count (PLT), and total iron-binding capacity (TIBC; which reflects the transferrin level) were examined in 29 patients who were treated with darbepoetin alfa (DA) and then switched to roxadustat (Rox).	Iron	25-29	transferrin	Homo sapiens	131-142
35051929-4	2022	METHODS: Relationship of iron-related factors with platelet count (PLT), and total iron-binding capacity (TIBC; which reflects the transferrin level) were examined in 29 patients who were treated with darbepoetin alfa (DA) and then switched to roxadustat (Rox).	Iron	83-87	transferrin	Homo sapiens	131-142
34614145-1	2022	The hormone erythroferrone (ERFE) is produced by erythroid cells in response to hemorrhage, hypoxia or other erythropoietic stimuli, and suppresses the hepatic production of the iron-regulatory hormone hepcidin, thereby mobilizing iron for erythropoiesis.	Iron	231-235	erythroferrone	Mus musculus	28-32
34614145-4	2022	We generated three lines of transgenic mice with graded erythroid overexpression of ERFE and showed that they developed dose-dependent iron overload, impaired hepatic BMP signaling and relative hepcidin deficiency.	Iron	135-139	erythroferrone	Mus musculus	84-88
34614145-5	2022	These findings add to the evidence that ERFE is a mediator of iron overload in conditions where ERFE is overproduced, including anemias with ineffective erythropoiesis.	Iron	62-66	erythroferrone	Mus musculus	40-44
34614145-5	2022	These findings add to the evidence that ERFE is a mediator of iron overload in conditions where ERFE is overproduced, including anemias with ineffective erythropoiesis.	Iron	62-66	erythroferrone	Mus musculus	96-100
34614145-7	2022	Neutralizing excessive ERFE in congenital anemias with ineffective erythropoiesis may not only prevent iron overload but may have additional benefits for growth and development.	Iron	103-107	erythroferrone	Mus musculus	23-27
35126480-1	2022	Acyl-CoA Synthetase long-chain family member 4 (ACSL4) is a member of acyl-CoA synthetase protein long-chain family, which is associated with amino acid synthesis, lipid synthesis and lipid peroxidation dependent iron death.	Iron	213-217	acyl-CoA synthetase long chain family member 4	Homo sapiens	0-46
35127502-8	2021	This reprogramming might be responsible for mitochondrial iron-sulfur (Fe-S) cluster biogenesis, which has become an "Achilles" heel," rendering cancer cells vulnerable to DFO-induced autophagic cell death and apoptosis through c-Jun N-terminal kinase (JNK) signaling.	Iron	71-75	mitogen-activated protein kinase 8	Homo sapiens	228-251
35126480-1	2022	Acyl-CoA Synthetase long-chain family member 4 (ACSL4) is a member of acyl-CoA synthetase protein long-chain family, which is associated with amino acid synthesis, lipid synthesis and lipid peroxidation dependent iron death.	Iron	213-217	acyl-CoA synthetase long chain family member 4	Homo sapiens	48-53
35038927-4	2022	ACSL4 is a key component of ferroptosis, an iron-dependent, nonapoptotic programmed cell death.	Iron	44-48	acyl-CoA synthetase long chain family member 4	Homo sapiens	0-5
35090332-0	2022	The association of vascular endothelial growth factor related SNPs and circulating iron levels might depend on body mass index.	Iron	83-87	vascular endothelial growth factor A	Homo sapiens	19-53
35090332-4	2022	This study investigated the association of those ten VEGF-related SNPs with serum iron levels in a general Lebanese population free of chronic diseases (N = 460).	Iron	82-86	vascular endothelial growth factor A	Homo sapiens	53-57
35127502-8	2021	This reprogramming might be responsible for mitochondrial iron-sulfur (Fe-S) cluster biogenesis, which has become an "Achilles" heel," rendering cancer cells vulnerable to DFO-induced autophagic cell death and apoptosis through c-Jun N-terminal kinase (JNK) signaling.	Iron	71-75	mitogen-activated protein kinase 8	Homo sapiens	253-256
35079622-0	2022	FDX2 and ISCU Gene Variations Lead to Rhabdomyolysis With Distinct Severity and Iron Regulation.	Iron	80-84	iron-sulfur cluster assembly enzyme	Homo sapiens	9-13
35079622-9	2022	Discussion: We conclude that FDX2 and ISCU variants result in a similar muscle phenotype, that differ in severity and skeletal muscle iron accumulation.	Iron	134-138	iron-sulfur cluster assembly enzyme	Homo sapiens	38-42
35033194-6	2022	Blood count parameters, serum ferritin, and liver transferrin bound iron were determined by automated counter.	Iron	68-72	transferrin	Rattus norvegicus	50-61
35173863-7	2022	Our results indicate several targets and pathways, including IL-4/IL-13, ACE, and HIF-1 signaling, that may have an important role in heme iron-mediated CRC and must be given consideration for understanding their role in colorectal cancer.	Iron	139-143	interleukin 4	Homo sapiens	61-65
35023715-2	2022	Herein, we report the facile construction of a multifunctional theranostic nanoplatform based on doxorubicin (DOX)-loaded tannic acid (TA)-iron (Fe) networks (for short, TAF) coated with fibronectin (FN) for combination tumor chemo-/chemodynamic/immune therapy under the guidance of magnetic resonance (MR) imaging.	Iron	139-143	fibronectin 1	Homo sapiens	187-198
35173863-7	2022	Our results indicate several targets and pathways, including IL-4/IL-13, ACE, and HIF-1 signaling, that may have an important role in heme iron-mediated CRC and must be given consideration for understanding their role in colorectal cancer.	Iron	139-143	interleukin 13	Homo sapiens	66-71
35173863-7	2022	Our results indicate several targets and pathways, including IL-4/IL-13, ACE, and HIF-1 signaling, that may have an important role in heme iron-mediated CRC and must be given consideration for understanding their role in colorectal cancer.	Iron	139-143	angiotensin I converting enzyme	Homo sapiens	73-76
35173863-7	2022	Our results indicate several targets and pathways, including IL-4/IL-13, ACE, and HIF-1 signaling, that may have an important role in heme iron-mediated CRC and must be given consideration for understanding their role in colorectal cancer.	Iron	139-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-87
35023715-2	2022	Herein, we report the facile construction of a multifunctional theranostic nanoplatform based on doxorubicin (DOX)-loaded tannic acid (TA)-iron (Fe) networks (for short, TAF) coated with fibronectin (FN) for combination tumor chemo-/chemodynamic/immune therapy under the guidance of magnetic resonance (MR) imaging.	Iron	145-147	fibronectin 1	Homo sapiens	187-198
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	Srl1p	Saccharomyces cerevisiae S288C	147-151
35056799-6	2022	Transcription factor enrichment and correlation analysis identified key transcription factors that were activated in both cultured cells and tissue by iron deficiency, including those implicated in iron regulation, such as HIF1, NFY, and NRF1.	Iron	198-202	nuclear respiratory factor 1	Rattus norvegicus	238-242
35022042-4	2022	METHODS: Intra- and extracellular iron was measured in cell-line-derived and in freshly isolated sputum macrophages under various experimental conditions including treatment with exogenous IL-6 and hepcidin.	Iron	34-38	interleukin 6	Homo sapiens	189-193
35022042-8	2022	IL-6 and hepcidin play roles in pulmonary iron sequestration, though IL-6 appears to exert its effect via a hepcidin-independent mechanism.	Iron	42-46	interleukin 6	Homo sapiens	0-4
35022042-12	2022	Specifically, IL-6-dependent iron sequestration by sputum macrophages may result in immune cell dysfunction and ultimately lead to increased frequency of infective exacerbation.	Iron	29-33	interleukin 6	Homo sapiens	14-18
35014607-6	2022	We also demonstrate that the increase in hepcidin is associated with increased ubiquitination and reduced levels of the only iron exporter, ferroportin-1 (FPN1).	Iron	125-129	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	140-153
35014607-6	2022	We also demonstrate that the increase in hepcidin is associated with increased ubiquitination and reduced levels of the only iron exporter, ferroportin-1 (FPN1).	Iron	125-129	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	155-159
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	catalase T	Saccharomyces cerevisiae S288C	221-225
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	349-353
35013423-4	2022	To test this hypothesis, we performed for the first time the advanced statistical multivariate analysis based on chemical composition and lead isotope systematics, coupled with informed typo-chronological categorisation, of a suite of late Iron Age and Early Roman period (first century BC - first century AD) brass and other copper-alloy artefacts from the territory of Bohemia.	Iron	240-244	renin binding protein	Homo sapiens	245-248
35466128-5	2022	Recent studies demonstrated that macrophage polarization is related to adipocyte hypertrophy and insulin resistance through their capabilities of iron handling.	Iron	146-150	insulin	Homo sapiens	97-104
35052629-1	2022	A series of studies indicated that iron distribution that partly derives from transferrin-bound iron in the peripheral nervous system in the brain may act in processes such as myelination and brain development.	Iron	35-39	transferrin	Homo sapiens	78-89
35052629-1	2022	A series of studies indicated that iron distribution that partly derives from transferrin-bound iron in the peripheral nervous system in the brain may act in processes such as myelination and brain development.	Iron	96-100	transferrin	Homo sapiens	78-89
35008976-0	2022	Thymosin beta4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis.	Iron	32-36	thymosin beta 4 X-linked	Homo sapiens	0-14
35001155-3	2022	In the current study, we report that intracellular M.tb exploits mammalian secreted Glyceraldehyde 3-phosphate dehydrogenase (sGAPDH) for the delivery of host iron carrier proteins lactoferrin (Lf) and transferrin (Tf).	Iron	159-163	transferrin	Homo sapiens	202-213
34890142-6	2022	Disease risk conferred by ApoE4 may be linked with higher subcortical iron burden in conjunction with inflammation or neuronal loss in aging individuals, while ApoE2 associations may not necessarily reflect unhealthy iron deposits earlier in life.	Iron	70-74	apolipoprotein E	Homo sapiens	26-31
34710708-0	2022	Triad role of hepcidin, ferroportin, and Nrf2 in cardiac iron metabolism: From health to disease.	Iron	57-61	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
34710708-5	2022	Iron availability to the heart is therefore tightly regulated by (i) the hepcidin/ferroportin axis, which controls dietary iron absorption, storage, and recycling, and (ii) iron regulatory proteins 1 and 2 (IRP1/2) via hypoxia inducible factor 1 (HIF1) pathway.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	219-245
34710708-5	2022	Iron availability to the heart is therefore tightly regulated by (i) the hepcidin/ferroportin axis, which controls dietary iron absorption, storage, and recycling, and (ii) iron regulatory proteins 1 and 2 (IRP1/2) via hypoxia inducible factor 1 (HIF1) pathway.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	247-251
34710708-7	2022	Therefore, to combat iron-mediated oxidative stress, targeting Nrf2/ARE antioxidant signaling is rational.	Iron	21-25	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
34710708-8	2022	The involvement of Nrf2 in regulating several genes engaged in heme synthesis, iron storage, and iron export is beginning to be uncovered.	Iron	79-83	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
34710708-8	2022	The involvement of Nrf2 in regulating several genes engaged in heme synthesis, iron storage, and iron export is beginning to be uncovered.	Iron	97-101	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
34710708-9	2022	Consequently, it is possible that Nrf2/hepcidin/ferroportin might act as an epicenter connecting iron metabolism to redox alterations.	Iron	97-101	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
34710708-12	2022	Further, we emphasized the impact of Nrf2 on the interplay between systemic/cardiac iron control in the context of heart disease, particularly in myocardial ischemia and HF.	Iron	84-88	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
35124772-9	2021	Additionally, the changes in cell supernatant levels of Fe2+, SOD, MDA, and mRNA and protein expression of ferroptosis marker proteins confirmed the beneficial effects of the NRF2/FPN1 pathway on diabetic myocardial IRI related to iron metabolism and ferroptosis.	Iron	231-235	NFE2 like bZIP transcription factor 2	Rattus norvegicus	175-179
35233284-1	2022	Background: Iron deficiency is highly prevalent among patients undergoing chronic haemodialysis (HD) but its correct identification is often problematic as common biomarkers of iron status, such as transferrin saturation (TSAT) and ferritin, can be altered by inflammation or malnutrition.	Iron	177-181	transferrin	Homo sapiens	198-209
35124772-9	2021	Additionally, the changes in cell supernatant levels of Fe2+, SOD, MDA, and mRNA and protein expression of ferroptosis marker proteins confirmed the beneficial effects of the NRF2/FPN1 pathway on diabetic myocardial IRI related to iron metabolism and ferroptosis.	Iron	231-235	solute carrier family 40 member 1	Rattus norvegicus	180-184
35124772-0	2021	Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis.	Iron	113-117	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
35124772-0	2021	Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis.	Iron	113-117	solute carrier family 40 member 1	Rattus norvegicus	19-23
35124772-10	2021	Overall, these findings suggest that iron homeostasis-related ferroptosis plays an important role in aggravating myocardial IRI in diabetic rats, and NRF2/FPN1 pathway-mediated iron homeostasis and ferroptosis might be a promising therapeutic target against myocardial IRI in diabetes.	Iron	37-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	150-154
35124772-10	2021	Overall, these findings suggest that iron homeostasis-related ferroptosis plays an important role in aggravating myocardial IRI in diabetic rats, and NRF2/FPN1 pathway-mediated iron homeostasis and ferroptosis might be a promising therapeutic target against myocardial IRI in diabetes.	Iron	177-181	NFE2 like bZIP transcription factor 2	Rattus norvegicus	150-154
35124772-10	2021	Overall, these findings suggest that iron homeostasis-related ferroptosis plays an important role in aggravating myocardial IRI in diabetic rats, and NRF2/FPN1 pathway-mediated iron homeostasis and ferroptosis might be a promising therapeutic target against myocardial IRI in diabetes.	Iron	177-181	solute carrier family 40 member 1	Rattus norvegicus	155-159
2624102-0	1989	Transferrin receptor expression in normal, iron-deficient and iron-overloaded rats.	Iron	43-47	transferrin receptor	Rattus norvegicus	0-20
2626427-2	1989	The ferredoxin is composed of 97 amino acid residues, and its molecular weight is 10,599 excluding the iron-sulfur cluster.	Iron	103-107	ferredoxin	Cyanidium caldarium	4-14
2624102-0	1989	Transferrin receptor expression in normal, iron-deficient and iron-overloaded rats.	Iron	62-66	transferrin receptor	Rattus norvegicus	0-20
2624102-5	1989	Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats.	Iron	86-90	transferrin receptor	Rattus norvegicus	44-47
2601708-10	1989	The total amount of IRE-BP in the cytosol of cells is the same regardless of the prior iron treatment of the cell.	Iron	87-91	aconitase 1	Homo sapiens	20-26
2738107-0	1989	Maturation-associated loss and incomplete de novo synthesis of the transferrin receptor in peripheral sheep reticulocytes: response to heme and iron.	Iron	144-148	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	67-78
2592487-3	1989	The pattern changed when iron-free transferrin was treated with neuraminidase, which splits off the sialic acid from the carbohydrate chains.	Iron	25-29	neuraminidase 1	Homo sapiens	64-77
2473988-6	1989	The up-regulation of TrfR synthesis is specific in that expression of other macrophage membrane proteins is not affected by iron addition.	Iron	124-128	transferrin receptor	Homo sapiens	21-25
2473988-7	1989	Conversely, addition of an iron chelator induced a slight decrease of TrfR synthesis.	Iron	27-31	transferrin receptor	Homo sapiens	70-74
2473988-10	1989	These results suggests that in cultured human monocytes-macrophages, iron up-regulates TrfR expression, thus in sharp contrast to the negative feedback reported in a variety of other cell types.	Iron	69-73	transferrin receptor	Homo sapiens	87-91
2624102-5	1989	Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats.	Iron	105-109	transferrin receptor	Rattus norvegicus	44-47
2548436-4	1989	In these conditions the iron(III) non-heme and copper(II) ceruloplasmin concentration in serum was modified either during inflammation or after treatment with antiphlogistic agents: in carrageenan-injected rats the level of serum iron(III) non-heme was found to be very low, while the copper(II) ceruloplasmin concentration was partially reduced.	Iron	24-28	ceruloplasmin	Rattus norvegicus	58-71
2548436-4	1989	In these conditions the iron(III) non-heme and copper(II) ceruloplasmin concentration in serum was modified either during inflammation or after treatment with antiphlogistic agents: in carrageenan-injected rats the level of serum iron(III) non-heme was found to be very low, while the copper(II) ceruloplasmin concentration was partially reduced.	Iron	24-28	ceruloplasmin	Rattus norvegicus	296-309
2548436-4	1989	In these conditions the iron(III) non-heme and copper(II) ceruloplasmin concentration in serum was modified either during inflammation or after treatment with antiphlogistic agents: in carrageenan-injected rats the level of serum iron(III) non-heme was found to be very low, while the copper(II) ceruloplasmin concentration was partially reduced.	Iron	230-234	ceruloplasmin	Rattus norvegicus	58-71
2624102-5	1989	Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats.	Iron	105-109	transferrin receptor	Rattus norvegicus	44-47
2752428-1	1989	Iron regulates human transferrin receptor (hTR) expression by modulating the stability of cytoplasmic hTR mRNA.	Iron	0-4	transferrin receptor	Homo sapiens	21-41
2624102-5	1989	Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats.	Iron	105-109	transferrin receptor	Rattus norvegicus	44-47
2624102-6	1989	We conclude that TfR expression is negatively regulated by the tissue concentration of iron.	Iron	87-91	transferrin receptor	Rattus norvegicus	17-20
2583116-0	1989	Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3" untranslated region of the mRNA.	Iron	0-4	transferrin receptor	Homo sapiens	19-39
2752047-2	1989	The proton NMR spectrum of the deoxy myoglobin exhibits an NH signal from the proximal histidine at 78.6 ppm, indicating heme incorporation into the heme pocket to form the Fe-N(His-F8) bond.	Iron	173-177	myoglobin	Physeter catodon	37-46
2711187-6	1989	Iron starvation, leading to decreased ferritin translation, results in increased binding activity, which is explained by an increase in the fraction of the IRE-BP that is in a fully reduced state.	Iron	0-4	aconitase 1	Homo sapiens	156-162
2583116-0	1989	Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3" untranslated region of the mRNA.	Iron	61-65	transferrin receptor	Homo sapiens	19-39
2716041-3	1989	The iron binding moiety coincided with the major nontransferrin iron-containing material of endocytic vesicles labeled in vivo by incubation of cells with 59Fe, 125I-labeled transferrin.	Iron	4-8	serotransferrin	Oryctolagus cuniculus	52-63
2716041-3	1989	The iron binding moiety coincided with the major nontransferrin iron-containing material of endocytic vesicles labeled in vivo by incubation of cells with 59Fe, 125I-labeled transferrin.	Iron	64-68	serotransferrin	Oryctolagus cuniculus	52-63
2769797-5	1989	The association of TfR expression in regenerating motor neurons with direct uptake of iron into the brain provides evidence that iron uptake into neural tissue may be related to neuronal metabolic activation.	Iron	86-90	transferrin receptor	Homo sapiens	19-22
2769797-5	1989	The association of TfR expression in regenerating motor neurons with direct uptake of iron into the brain provides evidence that iron uptake into neural tissue may be related to neuronal metabolic activation.	Iron	129-133	transferrin receptor	Homo sapiens	19-22
2583116-1	1989	Post-transcriptional regulation of transferrin receptor mRNA levels by iron is mediated by a portion of the 3" untranslated region (UTR) of the mRNA.	Iron	71-75	transferrin receptor	Homo sapiens	35-55
2583116-6	1989	This sequence, which contains three IREs, is capable of producing iron-dependent regulation of transferrin receptor levels.	Iron	66-70	transferrin receptor	Homo sapiens	95-115
2759551-7	1989	Uroporphyrinogen decarboxylase activity was unchanged by drug and iron treatments.	Iron	66-70	uroporphyrinogen decarboxylase	Gallus gallus	0-30
2721585-3	1989	Iron uptake was monitored after the application of 59Fe-labeled ferric citrate or pig transferrin.	Iron	0-4	transferrin	Sus scrofa	86-97
2721585-5	1989	Replacement of pig transferrin with bovine transferrin resulted in similar intracellular iron levels, but the growth-stimulating effect of bovine transferrin was more than one order of magnitude lower.	Iron	89-93	transferrin	Sus scrofa	19-30
2462936-8	1989	These data suggest that cells with a high iron requirement synthesize two forms of transferrin receptor, possibly by means of differential mRNA splicing or by posttranslational modification of the transferrin receptor.	Iron	42-46	transferrin receptor	Homo sapiens	83-103
2788206-0	1989	Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum iron.	Iron	155-159	interleukin 1 complex	Mus musculus	85-98
2467243-2	1989	The colloidal iron and Alcian blue stains gave positive results with worn lenses without apparent interference and indicated that the mucin deposits were principally complex carbohydrates with free acidic groups.	Iron	14-18	LOC100508689	Homo sapiens	134-139
2914887-3	1989	High-to-low spin transitions of the heme iron occur for hemoglobin, myoglobin, and Glycera hemoglobin at 0.35, 0.75, and 0.50 GPa, respectively, for the deoxy species.	Iron	41-45	myoglobin	Physeter catodon	68-77
2771641-2	1989	A cytoplasmic protein (IRE-BP) binds to these cis-acting elements and mediates the translational regulation of ferritin H- and L-chain mRNA and the iron-dependent stability of transferrin receptor (TfR) mRNA.	Iron	148-152	aconitase 1	Homo sapiens	23-29
2916654-1	1989	The regulation of transferrin-receptor and ferritin synthesis by iron in cultured fibroblastic-line cells.	Iron	65-69	transferrin receptor	Homo sapiens	18-38
2492336-5	1989	However, severe and moderate iron deprivation resulted in a stimulation of G6P-DH and 6PG-DH activities per million erythrocytes.	Iron	29-33	glucose-6-phosphate dehydrogenase	Rattus norvegicus	75-81
3170563-1	1988	The effect of changes in cellular iron metabolism on the surface expression of transferrin receptors (TfR) was examined in primary cultures of hepatocytes from adult rats.	Iron	34-38	transferrin receptor	Rattus norvegicus	79-100
3170563-1	1988	The effect of changes in cellular iron metabolism on the surface expression of transferrin receptors (TfR) was examined in primary cultures of hepatocytes from adult rats.	Iron	34-38	transferrin receptor	Rattus norvegicus	102-105
3170563-3	1988	Following 24 h of treatment with the iron chelator, desferrioxamine, or with succinylacetone, an inhibitor of heme synthesis, the number of TfR at the cell surface was increased severalfold, with no significant change in receptor affinity (KD) for transferrin.	Iron	37-41	transferrin receptor	Rattus norvegicus	140-143
2771641-2	1989	A cytoplasmic protein (IRE-BP) binds to these cis-acting elements and mediates the translational regulation of ferritin H- and L-chain mRNA and the iron-dependent stability of transferrin receptor (TfR) mRNA.	Iron	148-152	transferrin receptor	Homo sapiens	176-196
3146537-4	1988	The results suggest that the inability to respond to cold in iron-deficient rats may be due to a reduction in the release of TRH from the hypothalamus.	Iron	61-65	thyrotropin releasing hormone	Rattus norvegicus	125-128
2771641-2	1989	A cytoplasmic protein (IRE-BP) binds to these cis-acting elements and mediates the translational regulation of ferritin H- and L-chain mRNA and the iron-dependent stability of transferrin receptor (TfR) mRNA.	Iron	148-152	transferrin receptor	Homo sapiens	198-201
2498873-0	1989	A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.	Iron	60-64	transferrin receptor	Homo sapiens	90-110
3415985-0	1988	Membrane transport of non-transferrin-bound iron by reticulocytes.	Iron	44-48	serotransferrin	Oryctolagus cuniculus	26-37
3415985-1	1988	The transport of non-transferrin-bound iron into rabbit reticulocytes was investigated by incubating the cells in 0.27 M sucrose with iron labelled with 59Fe.	Iron	39-43	serotransferrin	Oryctolagus cuniculus	21-32
3415985-3	1988	The iron was taken up by cytosolic, haem and stromal fractions of the cells in greater amounts than transferrin-iron.	Iron	112-116	serotransferrin	Oryctolagus cuniculus	100-111
2904432-2	1988	Tyrosine 3-monooxygenase (tyrosine hydroxylase) is a non-heme iron, tetrahydropterin-dependent enzyme which catalyzes the rate-limiting step in the biosynthesis of catecholamines.	Iron	62-66	tyrosine hydroxylase	Bos taurus	0-24
2904432-2	1988	Tyrosine 3-monooxygenase (tyrosine hydroxylase) is a non-heme iron, tetrahydropterin-dependent enzyme which catalyzes the rate-limiting step in the biosynthesis of catecholamines.	Iron	62-66	tyrosine hydroxylase	Bos taurus	26-46
2904432-8	1988	The energies of the catecholate to Fe(III) charge-transfer transitions indicate a mixture of histidines and carboxylate(s) coordinated to the iron center in tyrosine hydroxylase.	Iron	142-146	tyrosine hydroxylase	Bos taurus	157-177
3415985-14	1988	It is concluded that the reticulocyte can transport non-transferrin-bound iron into the cytosol by a carrier-mediated process and the question is raised whether the same carrier is utilized by transferrin-iron after its release from the protein.	Iron	74-78	serotransferrin	Oryctolagus cuniculus	56-67
2498873-1	1989	The level of mRNA encoding the transferrin receptor (TfR) is regulated by iron, and this regulation is mediated by a portion of the 3" untranslated region (UTR) of the TfR transcript.	Iron	74-78	transferrin receptor	Homo sapiens	31-51
3415985-14	1988	It is concluded that the reticulocyte can transport non-transferrin-bound iron into the cytosol by a carrier-mediated process and the question is raised whether the same carrier is utilized by transferrin-iron after its release from the protein.	Iron	205-209	serotransferrin	Oryctolagus cuniculus	193-204
3138981-5	1988	In contrast, hepatic uroporphyrin accumulation in male C57BL/6 mice treated with iron and hexachlorobenzene was accompanied by a 20-80% decrease in uroporphyrinogen decarboxylase activity, demonstrating that the assay used for uroporphyrinogen decarboxylase, using pentacarboxyporphyrinogen III as substrate, could detect decreased enzyme activity.	Iron	81-85	uroporphyrinogen decarboxylase	Mus musculus	148-178
3138981-5	1988	In contrast, hepatic uroporphyrin accumulation in male C57BL/6 mice treated with iron and hexachlorobenzene was accompanied by a 20-80% decrease in uroporphyrinogen decarboxylase activity, demonstrating that the assay used for uroporphyrinogen decarboxylase, using pentacarboxyporphyrinogen III as substrate, could detect decreased enzyme activity.	Iron	81-85	uroporphyrinogen decarboxylase	Mus musculus	227-257
2498873-1	1989	The level of mRNA encoding the transferrin receptor (TfR) is regulated by iron, and this regulation is mediated by a portion of the 3" untranslated region (UTR) of the TfR transcript.	Iron	74-78	transferrin receptor	Homo sapiens	53-56
2498873-2	1989	This portion of 3" UTR of the human TfR mRNA contains five RNA elements that have structural similarity to the iron-responsive element (IRE) found as a single copy in the 5" UTR of the mRNA for ferritin, whose translation is regulated by iron.	Iron	111-115	transferrin receptor	Homo sapiens	36-39
2498873-2	1989	This portion of 3" UTR of the human TfR mRNA contains five RNA elements that have structural similarity to the iron-responsive element (IRE) found as a single copy in the 5" UTR of the mRNA for ferritin, whose translation is regulated by iron.	Iron	238-242	transferrin receptor	Homo sapiens	36-39
2844718-3	1988	Compared with control animals, tibialis anterior skeletal muscles of iron-deficient animals exhibited reduced concentrations of cytochrome c (4.4 +/- 0.7 vs. 8.6 +/- 0.7 nmol/g tissue; P less than 0.01), and reduced activities of citrate synthase (83 +/- 10 vs. 133 +/- 13 mU/mg protein; P less than 0.01) and cytochrome-c oxidase (2.2 +/- 0.2 vs. 3.6 +/- 0.5 U/mg protein; P less than 0.05).	Iron	69-73	cytochrome c	Oryctolagus cuniculus	128-140
2646156-2	1989	Proliferating cells have an absolute requirement for iron, which is delivered by transferrin with subsequent intracellular transport via the transferrin receptor.	Iron	53-57	transferrin receptor	Homo sapiens	141-161
3379048-4	1988	The results are compatible with a model in which iron, at transferrin concentrations above that needed to saturate the transferrin receptor, is taken up from transferrin predominantly by mechanisms located to or contiguous with the plasma membrane.	Iron	49-53	transferrin receptor	Rattus norvegicus	119-139
3370673-1	1988	Expression of the human transferrin receptor (hTR) and its mRNA is strongly induced by iron deprivation.	Iron	87-91	transferrin receptor	Homo sapiens	24-44
18964558-1	1988	The use of oxazine dyes as redox indicators in the determination of uranium(VI), copper(II), osmium(VIII), iridium(IV) and thallium(III) with iron(II) as reductimetric titrant in phosphoric acid medium has been investigated.	Iron	142-146	cytochrome c oxidase subunit 8A	Homo sapiens	100-104
2536536-0	1989	The iron-sulfur protein is necessary for the complete assembly of the low-molecular-weight subunits into the cytochrome b-c1 complex of yeast mitochondria.	Iron	4-8	cytochrome b	Saccharomyces cerevisiae S288C	109-121
3379962-3	1988	Spectral studies showed that binding of 22-Thiol to cytochrome P450scc produces changes characteristic of sulfur coordination to the heme-iron, suggesting that its high affinity arises from a dual interaction with the cholesterol binding site and the heme.	Iron	138-142	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	52-70
3379962-4	1988	Together with previous results obtained with 22-amino and 22-hydroxy analogues, these findings provide support for the proximity of C-22 and the heme-iron of cytochrome P450scc in the enzyme-substrate complex.	Iron	150-154	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	158-176
3134296-5	1988	Addition of either recombinant IL-2 (rIL-2) or an iron chelator (picolinic acid) to lectin-pulsed PBM induces both a marked enhancement of TfR synthesis and a sharp decline of intracellular ferritin level, which are comparable to the corresponding pattern observed in control cultures.	Iron	50-54	transferrin receptor	Homo sapiens	139-142
3134296-7	1988	These observations strongly suggest that the enhanced TfR synthesis elicited by rIL-2 is mediated by depletion of a regulatory intracellular iron pool.	Iron	141-145	transferrin receptor	Homo sapiens	54-57
3134296-9	1988	Altogether, we postulate that: (i) in resting T lymphocytes the gene encoding TfR is apparently in a "closed" configuration; (ii) even in the absence of IL-2 activity, a mitogen pulse is sufficient to initiate the expression of TfRs, at least in part via a decline of intracellular iron level; and (iii) TfR synthesis is then largely amplified by IL-2, again via a decrease of the size of a regulatory intracellular iron pool.	Iron	282-286	transferrin receptor	Homo sapiens	78-81
3134296-9	1988	Altogether, we postulate that: (i) in resting T lymphocytes the gene encoding TfR is apparently in a "closed" configuration; (ii) even in the absence of IL-2 activity, a mitogen pulse is sufficient to initiate the expression of TfRs, at least in part via a decline of intracellular iron level; and (iii) TfR synthesis is then largely amplified by IL-2, again via a decrease of the size of a regulatory intracellular iron pool.	Iron	282-286	transferrin receptor	Homo sapiens	228-231
3134296-9	1988	Altogether, we postulate that: (i) in resting T lymphocytes the gene encoding TfR is apparently in a "closed" configuration; (ii) even in the absence of IL-2 activity, a mitogen pulse is sufficient to initiate the expression of TfRs, at least in part via a decline of intracellular iron level; and (iii) TfR synthesis is then largely amplified by IL-2, again via a decrease of the size of a regulatory intracellular iron pool.	Iron	416-420	transferrin receptor	Homo sapiens	78-81
3134296-9	1988	Altogether, we postulate that: (i) in resting T lymphocytes the gene encoding TfR is apparently in a "closed" configuration; (ii) even in the absence of IL-2 activity, a mitogen pulse is sufficient to initiate the expression of TfRs, at least in part via a decline of intracellular iron level; and (iii) TfR synthesis is then largely amplified by IL-2, again via a decrease of the size of a regulatory intracellular iron pool.	Iron	416-420	transferrin receptor	Homo sapiens	228-231
2536536-4	1989	Immunoblotting studies with antiserum against the cytochrome b-c1 complex revealed that mitochondria from the iron-sulfur protein-deficient strain have levels of core protein I, core protein II, and cytochrome c1 equal to those of wild-type mitochondria; however, a decrease in cytochrome b was evident from both immunoblotting and spectral analysis.	Iron	110-114	cytochrome b	Saccharomyces cerevisiae S288C	50-62
3047970-1	1988	Problems of ferrokinetics, participation of metalloproteins transferrin, ferritin and lactoferrin in metabolism of iron at the step of the metal absorption, transport of iron by means of transferrin, haptoglobin and hemopexin, interaction of transferrin with reticulocytes, deposition of iron in ferritin, mobilization of iron from ferritin via ceruloplasmin are considered.	Iron	115-119	hemopexin	Homo sapiens	216-225
2536536-4	1989	Immunoblotting studies with antiserum against the cytochrome b-c1 complex revealed that mitochondria from the iron-sulfur protein-deficient strain have levels of core protein I, core protein II, and cytochrome c1 equal to those of wild-type mitochondria; however, a decrease in cytochrome b was evident from both immunoblotting and spectral analysis.	Iron	110-114	cytochrome b	Saccharomyces cerevisiae S288C	278-290
2452485-1	1988	The biosynthetic rates for both the transferrin receptor (TfR) and ferritin are regulated by iron.	Iron	93-97	transferrin receptor	Homo sapiens	36-56
2536536-6	1989	These results suggest that the iron-sulfur protein is required for the complete assembly of the low-molecular-weight subunits into the cytochrome b-c1 complex.	Iron	31-35	cytochrome b	Saccharomyces cerevisiae S288C	135-147
2452485-1	1988	The biosynthetic rates for both the transferrin receptor (TfR) and ferritin are regulated by iron.	Iron	93-97	transferrin receptor	Homo sapiens	58-61
3355862-0	1988	Non-transferrin donors of iron for heme synthesis in immature erythroid cells.	Iron	26-30	serotransferrin	Oryctolagus cuniculus	4-15
2452485-3	1988	In this report the 3" untranslated region of the mRNA for the human TfR was shown to be necessary and sufficient for iron-dependent control of mRNA levels.	Iron	117-121	transferrin receptor	Homo sapiens	68-71
3355862-1	1988	The mechanism of iron uptake from several iron-containing compounds by transferrin-depleted rabbit reticulocytes and mouse spleen erythroid cells was investigated.	Iron	17-21	serotransferrin	Oryctolagus cuniculus	71-82
2916994-0	1989	Proton NMR study of the influence on iron oxidation/ligation/spin state on the heme orientational preference in myoglobin.	Iron	37-41	myoglobin	Physeter catodon	112-121
3355862-1	1988	The mechanism of iron uptake from several iron-containing compounds by transferrin-depleted rabbit reticulocytes and mouse spleen erythroid cells was investigated.	Iron	42-46	serotransferrin	Oryctolagus cuniculus	71-82
3355862-2	1988	Iron complexes of DL-penicillamine, citrate and six different aroyl hydrazones may be utilized by immature erythroid cells for hemoglobin synthesis, although less efficiently than iron from transferrin.	Iron	0-4	serotransferrin	Oryctolagus cuniculus	190-201
3355862-2	1988	Iron complexes of DL-penicillamine, citrate and six different aroyl hydrazones may be utilized by immature erythroid cells for hemoglobin synthesis, although less efficiently than iron from transferrin.	Iron	180-184	serotransferrin	Oryctolagus cuniculus	190-201
3355862-5	1988	Ammonium chloride (NH4Cl) increases intracellular pH and blocks the release or utilization of iron from the internalized transferrin.	Iron	94-98	serotransferrin	Oryctolagus cuniculus	121-132
3355862-7	1988	Hemin inhibited transferrin iron uptake and heme synthesis, but had a much lesser effect on iron incorporation and heme synthesis from non-transferrin donors of iron.	Iron	28-32	serotransferrin	Oryctolagus cuniculus	16-27
3355862-8	1988	These results allow us to conclude that transferrin-depleted reticulocytes take up iron from all of the examined non-transferrin iron donors without the involvement of the transferrin/transferrin receptor pathway.	Iron	83-87	serotransferrin	Oryctolagus cuniculus	40-51
2452485-4	1988	Deletion studies identified a 678-nucleotide fragment of the TfR complementary DNA that is critical for this iron regulation.	Iron	109-113	transferrin receptor	Homo sapiens	61-64
3162307-0	1988	Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.	Iron	50-54	transferrin receptor	Homo sapiens	81-101
3355862-8	1988	These results allow us to conclude that transferrin-depleted reticulocytes take up iron from all of the examined non-transferrin iron donors without the involvement of the transferrin/transferrin receptor pathway.	Iron	129-133	serotransferrin	Oryctolagus cuniculus	40-51
2916994-1	1989	Proton nuclear magnetic resonance spectroscopy has been utilized to demonstrate that the degree of heme orientational disorder within a given myoglobin protein matrix can be a sensitive function of the oxidation/ligation/spin state of the heme iron.	Iron	244-248	myoglobin	Physeter catodon	142-151
3679087-3	1987	We now report effects of iron-loading on three enzymes of heme synthesis: 5-aminolevulinate synthase; the first and rate-controlling enzyme of the pathway, 5-aminolevulinate dehydrase (or porphobilinogen synthase), and uroporphyrinogen decarboxylase, the activity of which is decreased in porphyria cutanea tarda, a liver disease in which iron is known to play an important but still poorly understood role.	Iron	25-29	uroporphyrinogen decarboxylase	Rattus norvegicus	219-249
3163302-6	1988	The altered transferrin receptor cycle led to a diminished iron uptake per surface transferrin receptor (approximately 30% of that in healthy subjects), and the incorporation of iron into heme was greatly reduced.	Iron	59-63	transferrin receptor	Homo sapiens	12-32
3264289-2	1988	With single intraperitoneal injections of IL-1 the plasma iron concentrations decreased significantly in mice with either normal neutrophil counts or neutropenia.	Iron	58-62	interleukin 1 complex	Mus musculus	42-46
3163302-6	1988	The altered transferrin receptor cycle led to a diminished iron uptake per surface transferrin receptor (approximately 30% of that in healthy subjects), and the incorporation of iron into heme was greatly reduced.	Iron	178-182	transferrin receptor	Homo sapiens	12-32
3224598-7	1988	The HNE-treated lungs showed clusters of ferric iron-containing macrophages in the terminal airspaces.	Iron	48-52	elastase, neutrophil expressed	Homo sapiens	4-7
3498729-1	1987	The transferrin (Tf) receptor is a major transmembrane protein which provides iron for normal and malignant cell growth.	Iron	78-82	transferrin receptor	Homo sapiens	4-29
3675556-0	1987	Chemically-induced formation of an inhibitor of hepatic uroporphyrinogen decarboxylase in inbred mice with iron overload.	Iron	107-111	uroporphyrinogen decarboxylase	Mus musculus	56-86
3675556-1	1987	An inhibitor of hepatic uroporphyrinogen decarboxylase (EC 4.1.1.37) was demonstrated in heat-treated extracts of livers from C57BL/10ScSn mice with iron overload after a single dose (100 mg/kg; 350 mumol/kg) of hexachlorobenzene (HCB).	Iron	149-153	uroporphyrinogen decarboxylase	Mus musculus	24-54
3264289-5	1988	4-d continuous infusions of IL-1 also led to reductions in serum iron concentrations, but transferrin concentrations doubled.	Iron	65-69	interleukin 1 complex	Mus musculus	28-32
3264289-7	1988	In mice not given cyclophosphamide, chronic IL-1 infusion was associated with a reduction in mean hemoglobin concentrations from 14.7 to 13.5 g/dl, consistent with restricted availability of iron for erythropoiesis associated with low saturation of transferrin.	Iron	191-195	interleukin 1 complex	Mus musculus	44-48
3264289-8	1988	We conclude that IL-1 can decrease the serum iron despite profound peripheral neutropenia and that transferrin in a positive acute phase reactant in the mouse.	Iron	45-49	interleukin 1 complex	Mus musculus	17-21
3497573-4	1987	IL-1 preparations from severely and moderately iron-deficient rats enhanced mouse thymocyte proliferation in vitro less than half as much as IL-1 preparations from control rats.	Iron	47-51	interleukin 1 complex	Mus musculus	0-4
3257741-8	1988	The influx of the partially saturated plasma protein transferrin through disrupted blood-ocular barriers most likely accounts for the increased TIBC in the inflamed eye and could provide some protection against the potentially harmful effects of Fe arising from tissue necrosis and hemolysis subsequent to hemorrhage.	Iron	246-248	serotransferrin	Oryctolagus cuniculus	53-64
3209510-6	1988	Serum Fe concentrations and percentage transferrin saturation in serum were increased (P less than .01) by supplemental Fe at 28 and 84 d, but not at the termination of the study.	Iron	120-122	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	39-50
2823079-4	1987	The hypothetical ADH does, however, show strong homology to the sequence of an iron-activated ADH from the bacterium Zymomonas mobilis.	Iron	79-83	alcohol dehydrogenase ADH4	Saccharomyces cerevisiae S288C	17-20
2823079-4	1987	The hypothetical ADH does, however, show strong homology to the sequence of an iron-activated ADH from the bacterium Zymomonas mobilis.	Iron	79-83	alcohol dehydrogenase ADH4	Saccharomyces cerevisiae S288C	94-97
3497573-5	1987	In a rabbit bioassay, injection of IL-1 prepared with PEC from either group of iron-deficient rats had little effect on body temperature or plasma minerals, while IL-1 from iron-adequate source PEC produced a febrile response and markedly lowered plasma iron and zinc in recipient rabbits.	Iron	173-177	interleukin 1 complex	Mus musculus	163-167
3497573-5	1987	In a rabbit bioassay, injection of IL-1 prepared with PEC from either group of iron-deficient rats had little effect on body temperature or plasma minerals, while IL-1 from iron-adequate source PEC produced a febrile response and markedly lowered plasma iron and zinc in recipient rabbits.	Iron	173-177	interleukin 1 complex	Mus musculus	163-167
3606611-1	1987	Multiple doses of beta-naphthoflavone to iron-loaded C57BL/10ScSn mice for 6 weeks caused inhibition of hepatic uroporphyrinogen decarboxylase and a porphyria indistinguishable from that previously only reported for polyhalogenated aromatic chemicals.	Iron	41-45	uroporphyrinogen decarboxylase	Mus musculus	112-142
3605340-6	1987	In addition, the iron-ascorbic system produced a dramatic decrease (greater than 50%) in the specific viscosity of mucin that was inhibited by catalase, deferoxamine, and mannitol.	Iron	17-21	LOC100508689	Homo sapiens	115-120
3209510-7	1988	Plasma Cu was decreased (P less than .01) at 56 d, whereas serum ceruloplasmin activity was reduced (P less than .01) at 28 d in lambs fed 1,200 mg Fe/kg diet compared with lambs fed 600 mg Fe/kg diet.	Iron	148-150	ceruloplasmin	Ovis aries	65-78
3605340-8	1987	These data suggest that hydroxyl radicals derived from the iron-catalyzed decomposition of hydrogen peroxide are responsible for the depolymerization of native mucin.	Iron	59-63	LOC100508689	Homo sapiens	160-165
3209510-8	1988	Lower levels of Fe (300 and 600) reduced (P less than .01) ceruloplasmin by 56 d and plasma Cu by 84 d compared with controls.	Iron	16-18	ceruloplasmin	Ovis aries	59-72
2444216-5	1987	The propensity of some fluids to release iron at low pH values, characteristic of the microenvironment beneath adherent macrophages, coupled with their decreased antioxidant protection against iron-stimulated oxygen-radical damage, might explain previously reported correlations between clinical disease severity, lipid peroxide content and the presence of bleomycin-detectable iron [Rowley, Gutteridge, Blake, Farr &amp; Halliwell (1984) Clin.	Iron	41-45	frataxin	Homo sapiens	411-415
3360800-2	1988	Heme formation in reticulocytes from rabbits and rodents is subject to end product negative feedback regulation: intracellular "free" heme has been shown to control acquisition of transferrin iron for heme synthesis.	Iron	192-196	serotransferrin	Oryctolagus cuniculus	180-191
3608980-2	1987	Transferrin receptor protein and mRNA levels are increased in cells treated with iron chelating agents, and are decreased by treatment with iron salts or hemin.	Iron	81-85	transferrin receptor	Homo sapiens	0-20
3036820-7	1987	Funiculosin completely inhibited the reoxidation of cytochrome b whereas the reoxidation of cytochrome c1 exhibited simple first-order kinetics in the presence of this inhibitor, implying that the iron-sulfur cluster is on the direct path of electron transfer from cytochrome b to cytochrome c1.	Iron	197-201	cytochrome b	Saccharomyces cerevisiae S288C	265-277
3492923-2	1987	We studied the role of granulocytes and lactoferrin (LF) in endotoxin and murine interleukin 1 (IL-1)-induced depression of serum Fe and Zn concentrations in both rabbits and rats.	Iron	130-132	interleukin 1 complex	Mus musculus	81-100
3608980-5	1987	Regulation by iron is observed when transcription is initiated at either the SV-40 early promoter or the transferrin receptor promoter, but deletion of a 2.3 kb fragment within the 2.6 kb 3" noncoding region of the cDNA abolishes regulation and increases the constitutive level of receptor expression.	Iron	14-18	transferrin receptor	Homo sapiens	105-125
3342069-4	1988	Examination of the single-cycle endocytosis of transferrin with pulse-chased technique suggests that DIDS retarded transferrin internalization, iron unloading and transferrin receptor recycling in the cells.	Iron	144-148	serotransferrin	Oryctolagus cuniculus	47-58
3031028-7	1987	When myeloperoxidase was isolated from the cells incubated with [59Fe]heme-hemopexin complex by immunoprecipitation with anti-myeloperoxidase antibody, radiolabeled iron associated with myeloperoxidase increased with time, and more than 30% of the radioactivity in the cells was present in the myeloperoxidase.	Iron	165-169	hemopexin	Homo sapiens	75-84
3605788-0	1987	Relationship between rabbit transferrin electrophoretic patterns and plasma iron concentrations.	Iron	76-80	serotransferrin	Oryctolagus cuniculus	28-39
3605788-5	1987	The degree of iron saturation of Tf varied among individuals and throughout the individual"s life.	Iron	14-18	serotransferrin	Oryctolagus cuniculus	33-35
3169366-6	1988	Incubation of heavy and light endosomes with PBS or PIH showed equal ATP specific iron release from both heavy and light endosomes, but in the presence of a NADH/NAD+ redox couple iron release from light endosomes was reduced.	Iron	82-86	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	52-55
3789140-3	1986	In rats made iron deficient, the specific (per unit protein) and the total (per total intestinal length) activities of sucrase, lactase, maltase, aminopeptidase, and diamine oxidase were decreased from -17 to -66% compared with the activities measured in the controls.	Iron	13-17	amine oxidase, copper containing 1	Rattus norvegicus	166-181
3028266-2	1987	The enzyme is a yellowish brown iron-sulfur protein, containing four nonheme iron and labile sulfide groups, that catalyzes the activation of NADP-malate dehydrogenase and fructose 1,6-bisphosphatase in the presence of ferredoxin and of thioredoxin m and f, respectively.	Iron	32-36	fructose-1,6-bisphosphatase	Zea mays	172-199
3464611-2	1986	However, results from our laboratory with reticulocytes suggest that the rate of iron uptake from transferrin (Tf), rather than ALA synthase activity, limits the rate of heme synthesis in erythroid cells.	Iron	81-85	serotransferrin	Oryctolagus cuniculus	98-109
3335579-7	1988	The results provide strong support for the concept that transferrin endocytosis is a necessary step in iron uptake by reticulocytes.	Iron	103-107	serotransferrin	Oryctolagus cuniculus	56-67
3464611-2	1986	However, results from our laboratory with reticulocytes suggest that the rate of iron uptake from transferrin (Tf), rather than ALA synthase activity, limits the rate of heme synthesis in erythroid cells.	Iron	81-85	serotransferrin	Oryctolagus cuniculus	111-113
3464611-5	1986	Therefore the possibility was investigated that, in induced cells, iron uptake from Tf limits and controls heme synthesis.	Iron	67-71	serotransferrin	Oryctolagus cuniculus	84-86
3464611-7	1986	Both induced and uninduced Friend cells take up and utilize Fe for heme synthesis directly from Fe-SIH without the involvement of transferrin and transferrin receptors and to a much greater extent than from saturating levels of Fe-Tf (20 microM).	Iron	60-62	serotransferrin	Oryctolagus cuniculus	231-233
3464611-11	1986	These results indicate that some step(s) in the pathway of iron from extracellular Tf to protoporphyrin, rather than the activity of ALA synthase, limits and controls the overall rate of heme and possibly hemoglobin synthesis in differentiating Friend erythroleukemia cells.	Iron	59-63	serotransferrin	Oryctolagus cuniculus	83-85
3549812-1	1987	In the majority of human cells the transferrin receptor (TFR) plays an important role by mediating the cellular iron uptake.	Iron	112-116	transferrin receptor	Homo sapiens	35-55
3549812-1	1987	In the majority of human cells the transferrin receptor (TFR) plays an important role by mediating the cellular iron uptake.	Iron	112-116	transferrin receptor	Homo sapiens	57-60
3026504-1	1987	Lineshape simulations are presented for the multiple, overlapping X-band electron paramagnetic resonance (EPR) spectra in two non-heme, high-spin iron proteins: phenylalanine hydroxylase (PAH) and diferric transferrin.	Iron	146-150	phenylalanine hydroxylase	Homo sapiens	161-186
3026504-1	1987	Lineshape simulations are presented for the multiple, overlapping X-band electron paramagnetic resonance (EPR) spectra in two non-heme, high-spin iron proteins: phenylalanine hydroxylase (PAH) and diferric transferrin.	Iron	146-150	phenylalanine hydroxylase	Homo sapiens	188-191
3026504-4	1987	In both PAH and transferrin, at least one of the iron sites is characterized by the ratio of zero-field splitting parameters, E/D, near 1/3 and a broad, asymmetric lineshape.	Iron	49-53	phenylalanine hydroxylase	Homo sapiens	8-11
2898829-8	1988	This supports the previously reported disappearance of hepatic TfR expression in HC when iron overload is severe.	Iron	89-93	transferrin receptor	Homo sapiens	63-66
3026504-9	1987	When applied to spectra of PAH in the resting state, the E/D-distribution approach accounts for the intensity of one of the two major species of iron.	Iron	145-149	phenylalanine hydroxylase	Homo sapiens	27-30
3825173-6	1987	In the case of cytochrome P-450b, the acetylamino group of paracetamol most closely approached the haem iron ion.	Iron	104-108	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	15-32
3822985-7	1986	Phosvitin demonstrated higher capacity to inhibit iron catalysis of phospholipid oxidations (up to 30:1 Fe2+-to-phosvitin molar ratio) than copper catalysis (1:1 molar ratio).	Iron	50-54	casein kinase 2 beta	Homo sapiens	0-9
3822985-7	1986	Phosvitin demonstrated higher capacity to inhibit iron catalysis of phospholipid oxidations (up to 30:1 Fe2+-to-phosvitin molar ratio) than copper catalysis (1:1 molar ratio).	Iron	50-54	casein kinase 2 beta	Homo sapiens	112-121
3822985-8	1986	Pasteurization did not change the antioxidant activities of phosvitin; however, autoclaving decreased phosvitin"s inhibitory capacity on iron catalysis.	Iron	137-141	casein kinase 2 beta	Homo sapiens	102-111
3810041-0	1986	Role of iron in the proliferation of the established human tumor cell lines U-937 and K-562: effects of suramin and a lipophilic iron chelator (PIH).	Iron	129-133	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	144-147
3568132-1	1987	The transferrin receptor (TR) mediates cellular iron uptake by bringing about the endocytosis of transferrin.	Iron	48-52	transferrin receptor	Homo sapiens	4-24
3527760-10	1986	Uteroferrin and transferrin, the iron transport protein of plasma, appear to be unrelated proteins.	Iron	33-37	transferrin	Sus scrofa	16-27
3095475-9	1986	With regard to activation-associated lymphocyte markers, iron significantly enhanced expression of the receptor for transferrin as identified by the monoclonal antibody, OKT9.	Iron	57-61	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	116-127
3568132-1	1987	The transferrin receptor (TR) mediates cellular iron uptake by bringing about the endocytosis of transferrin.	Iron	48-52	transferrin receptor	Homo sapiens	26-28
3772017-3	1986	The method has been used to determine the stoichiometry of iron for nanomole quantities of heme-iron proteins, iron-sulfur proteins, complex iron-sulfur proteins, as well as in phenylalanine hydroxylase, an enzyme with iron in an undetermined coordination.	Iron	59-63	phenylalanine hydroxylase	Homo sapiens	177-202
3697365-8	1986	These results clearly established that the 461st cysteine residue in cytochrome P-450scc plays a role as the heme fifth ligand on the basis of the general agreement that a thiolated cysteine residue coordinates to the heme iron.	Iron	223-227	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	80-88
3028266-2	1987	The enzyme is a yellowish brown iron-sulfur protein, containing four nonheme iron and labile sulfide groups, that catalyzes the activation of NADP-malate dehydrogenase and fructose 1,6-bisphosphatase in the presence of ferredoxin and of thioredoxin m and f, respectively.	Iron	77-81	fructose-1,6-bisphosphatase	Zea mays	172-199
3513989-10	1986	The mechanism of acquired UROD-deficiency is not clear but animal studies suggest a role for the hepatic mixed function oxygenases which initiate iron-dependent inactivation of UROD.	Iron	146-150	uroporphyrinogen decarboxylase	Homo sapiens	26-30
3019383-1	1986	Iron can be bound to phenylalanine hydroxylase (PAH) in two environments.	Iron	0-4	phenylalanine hydroxylase	Homo sapiens	21-46
3442377-5	1987	As in the human syndrome porphyria cutanea tarda, iron administration increased porphyrin accumulation and the degree of reduction of UROD activity in mice fed HCB.	Iron	50-54	uroporphyrinogen decarboxylase	Homo sapiens	134-138
3019383-1	1986	Iron can be bound to phenylalanine hydroxylase (PAH) in two environments.	Iron	0-4	phenylalanine hydroxylase	Homo sapiens	48-51
3019385-0	1986	Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen.	Iron	0-4	endogenous retrovirus group K member 7	Homo sapiens	71-81
3712215-2	1986	The purified protein, designated as LC-2, was identified as a variant of mouse transferrin, which is a serum beta 1-globulin having an iron-binding capacity.	Iron	135-139	dynein light chain Tctex-type 2A1	Mus musculus	36-40
3533647-6	1986	Hepatocytes also obtain some iron from haptoglobin-hemoglobin, heme-hemopexin, and ferritin (Fn), in each case by interaction with membrane receptors and endocytosis.	Iron	29-33	hemopexin	Homo sapiens	68-77
3945969-5	1986	Combined treatment with ethinyl estradiol plus iron partially corrected the reduction of BSIF and restored the activity of ALA-S and URO-D to control levels.	Iron	47-51	uroporphyrinogen decarboxylase	Rattus norvegicus	133-138
3826757-2	1986	For identification of the different iron-binding sites of transferrin a stepwise urea gradient, different degrees of iron saturation and double one-dimensional electrophoresis were used.	Iron	36-40	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	58-69
3826757-2	1986	For identification of the different iron-binding sites of transferrin a stepwise urea gradient, different degrees of iron saturation and double one-dimensional electrophoresis were used.	Iron	117-121	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	58-69
3741545-5	1986	In fact, DF by reducing liver iron levels produced a smaller decrease of the target enzyme (PCL) and a concomitant smaller induction of ALA-S.	Iron	30-34	uroporphyrinogen decarboxylase	Rattus norvegicus	92-95
3741545-9	1986	They suggest that iron plays an indirect role in the decrease of PCL enzyme, possibly at the HCB metabolization step.	Iron	18-22	uroporphyrinogen decarboxylase	Rattus norvegicus	65-68
3792344-8	1986	The results suggest that the two postulated pathways of the transferrin-cell cycle (a fast, iron-donating and a slow, receptor-shedding cycle) are not similarly involved in the cellular processing of Tf and AuTf.	Iron	92-96	serotransferrin	Oryctolagus cuniculus	60-71
3013902-1	1986	Specific binding of ferric bovine transferrin to the human transferrin receptor was investigated using K562 cells propagated in serum-free medium without transferrin supplemented with 10(-5) elemental iron.	Iron	201-205	transferrin receptor	Homo sapiens	59-79
3013846-3	1986	The results indicated, however, that both agents acted to 1) retard the internalization of transferrin bound to transferrin receptors on the plasma membrane of reticulocytes, 2) retard the externalization of internalized transferrin, and 3) block the transport into the cytosol of iron released from transferrin.	Iron	281-285	serotransferrin	Oryctolagus cuniculus	91-102
3006970-4	1986	The study reported here focuses on the effects of phosvitin, a suspected inhibitor of iron absorption found in egg yolks, on the chemistry of iron during the in vitro enzymatic digestion of pinto beans.	Iron	86-90	casein kinase 2 beta	Homo sapiens	50-59
3006970-4	1986	The study reported here focuses on the effects of phosvitin, a suspected inhibitor of iron absorption found in egg yolks, on the chemistry of iron during the in vitro enzymatic digestion of pinto beans.	Iron	142-146	casein kinase 2 beta	Homo sapiens	50-59
3800966-10	1986	The results suggest that the inhibition of hepatic uroporphyrinogen decarboxylase is unlikely to be due to a direct effect of a metabolite of HCB but to another process requiring a specific cytochrome P-450 isoenzyme and an unknown iron species.	Iron	232-236	uroporphyrinogen decarboxylase	Mus musculus	51-81
3785148-0	1986	Transcriptional regulation by iron of the gene for the transferrin receptor.	Iron	30-34	transferrin receptor	Homo sapiens	55-75
3785148-3	1986	By using a cDNA clone of the human transferrin receptor, we showed that the changes in the levels of the receptor by iron were accompanied by alterations in the levels of the mRNA for the receptor.	Iron	117-121	transferrin receptor	Homo sapiens	35-55
3930497-10	1985	Detergent-activated tyrosinase has a KM for dihydroxyphenylalanine of 6 X 10(-4) M and a KM for tyrosine of 4 X 10(-4) M. Both activities are inhibited by copper chelators but not by an iron chelator.	Iron	186-190	tyrosinase	Xenopus laevis	20-30
3013043-12	1986	These observations indicate that GPBP/transferrin-induced adherence of granulocytes to pollen grains is a hitherto unrecognized property of transferrin which appears unrelated to iron transport or the conventional transferrin receptor.	Iron	179-183	GC-rich promoter binding protein 1	Homo sapiens	33-37
2862415-6	1985	It is suggested that clinically overt PCT is precipitated by an iron-dependent process which inactivates the active centres of uroporphyrinogen decarboxylase molecules in the liver.	Iron	64-68	uroporphyrinogen decarboxylase	Homo sapiens	127-157
3840689-2	1985	Through the use of catalase, superoxide dismutase and the specific iron chelator diethylenetriaminepentaacetic acid, the active species responsible for inhibition was shown to be hydrogen peroxide.	Iron	67-71	catalase	Bos taurus	19-27
3755593-4	1986	Furthermore, the pH optimum of the ferroxidase activity of the enzyme is compatible with the conditions of pH that normally exist in the intestinal mucosa, where it has been proposed that xanthine oxidoreductase may facilitate the absorption of ionic iron.	Iron	251-255	xanthine dehydrogenase	Rattus norvegicus	188-211
4043380-1	1985	Studies on the inherent biochemical defect in highly purified human erythrocyte uroporphyrinogen decarboxylase and its amplification by iron.	Iron	136-140	uroporphyrinogen decarboxylase	Homo sapiens	80-110
6860330-1	1983	To test the hypothesis that ferroxidase I (ceruloplasmin) activity is essential for iron mobilization, adult rats were fed a copper sufficient diet with or without the chelating drugs D-penicillamine and triethylenetetramine for 120 days.	Iron	84-88	ceruloplasmin	Rattus norvegicus	43-56
2996121-3	1985	The studies of the morphology of the Tf-TfR system by fluorescence based methods using labelling by FITC-Tf, and by indirect immunofluorescence (OKT9 anti-TfR monoclonal antibody) demonstrated that the iron uptake was the result of receptor-mediated endocytosis (RME) of the Tf-TfR complex.	Iron	202-206	transferrin receptor	Homo sapiens	40-43
6827918-4	1983	The N-terminal monoferric transferrin, however, remained unchanged suggesting that in the process of transferrin uptake by cells, the diferric transferrin releases its iron from the acid-labile site at N-domain first before the other iron from the acid-stable site.	Iron	168-172	serotransferrin	Oryctolagus cuniculus	101-112
3711888-0	1986	Iron binding by phosvitin: variation of rate of iron release as a function of the degree of saturation of iron binding sites.	Iron	0-4	casein kinase 2 beta	Homo sapiens	16-25
6827918-4	1983	The N-terminal monoferric transferrin, however, remained unchanged suggesting that in the process of transferrin uptake by cells, the diferric transferrin releases its iron from the acid-labile site at N-domain first before the other iron from the acid-stable site.	Iron	168-172	serotransferrin	Oryctolagus cuniculus	101-112
6827918-4	1983	The N-terminal monoferric transferrin, however, remained unchanged suggesting that in the process of transferrin uptake by cells, the diferric transferrin releases its iron from the acid-labile site at N-domain first before the other iron from the acid-stable site.	Iron	234-238	serotransferrin	Oryctolagus cuniculus	101-112
6827918-4	1983	The N-terminal monoferric transferrin, however, remained unchanged suggesting that in the process of transferrin uptake by cells, the diferric transferrin releases its iron from the acid-labile site at N-domain first before the other iron from the acid-stable site.	Iron	234-238	serotransferrin	Oryctolagus cuniculus	101-112
2413049-1	1985	We investigated the effects of the iron chelator desferrioxamine on the expression of transferrin receptors (TfR) by CCRF-CEM human T-cell leukaemia and B16 mouse melanoma cells growing in tissue culture.	Iron	35-39	transferrin receptor	Homo sapiens	86-107
2413049-1	1985	We investigated the effects of the iron chelator desferrioxamine on the expression of transferrin receptors (TfR) by CCRF-CEM human T-cell leukaemia and B16 mouse melanoma cells growing in tissue culture.	Iron	35-39	transferrin receptor	Homo sapiens	109-112
2413049-10	1985	These results provide further evidence that the regulation of TfR expression by proliferating cells is specifically linked to DNA synthesis rather than to the iron requirements of other cellular processes.	Iron	159-163	transferrin receptor	Homo sapiens	62-65
3711888-0	1986	Iron binding by phosvitin: variation of rate of iron release as a function of the degree of saturation of iron binding sites.	Iron	48-52	casein kinase 2 beta	Homo sapiens	16-25
3711888-0	1986	Iron binding by phosvitin: variation of rate of iron release as a function of the degree of saturation of iron binding sites.	Iron	106-110	casein kinase 2 beta	Homo sapiens	16-25
6822531-8	1983	A complex of this form with P-450scc produced a 422 nm Soret absorption maximum as found for the parent compound, indicating nitrogen coordination to the heme iron.	Iron	159-163	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	28-36
3711888-1	1986	The rate of iron release from Fe(III)-phosvitin complexes, at varied degrees of saturation, was studied.	Iron	12-16	casein kinase 2 beta	Homo sapiens	38-47
3947082-0	1986	In vitro studies of the mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron under anaerobic conditions.	Iron	104-116	uroporphyrinogen decarboxylase	Rattus norvegicus	61-91
2990471-0	1985	Bovine heart cytochrome c oxidase preparations contain high affinity binding sites for magnesium as well as for zinc, copper, and heme iron.	Iron	135-139	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-33
3545211-1	1986	The transferrin receptor binds the major serum iron-transport protein, transferrin, and mediates cellular iron uptake.	Iron	47-51	transferrin receptor	Homo sapiens	4-24
4017107-4	1985	These results indicate that redox cycling compounds do not initiate lipid peroxidation by themselves, but are well capable of stimulating the iron-induced LPO.	Iron	142-146	lactoperoxidase	Mus musculus	155-158
6305740-0	1983	Binding of transferrin-iron to the plasma membrane of a lactating rabbit mammary gland cell.	Iron	23-27	serotransferrin	Oryctolagus cuniculus	11-22
3486371-1	1986	Serum ferritin levels were measured in 57 patients on maintenance haemodialysis to determine if patients who possessed 1 or more of the histocompatibility antigens associated with idiopathic haemochromatosis (HLA A3, B7 or B14) were at increased risk of iron overload.	Iron	254-258	CD80 molecule	Homo sapiens	209-226
6572903-1	1983	Ferritin is the intracellular iron storage protein.	Iron	30-34	ferritin, mitochondrial	Cricetulus griseus	0-8
6572903-2	1983	Tissue ferritin stores are markedly increased in hemochromatosis, a disease of iron overload that has been linked to chromosome 6.	Iron	79-83	ferritin, mitochondrial	Cricetulus griseus	7-15
4016967-3	1985	Since intracellular release of iron from transferrin is believed to involve the protonation of the iron-transferrin complex, the rise in intralysomal pH could account for the inhibitory effect of spermine on iron uptake.	Iron	31-35	serotransferrin	Oryctolagus cuniculus	41-52
4016967-3	1985	Since intracellular release of iron from transferrin is believed to involve the protonation of the iron-transferrin complex, the rise in intralysomal pH could account for the inhibitory effect of spermine on iron uptake.	Iron	31-35	serotransferrin	Oryctolagus cuniculus	104-115
4016967-3	1985	Since intracellular release of iron from transferrin is believed to involve the protonation of the iron-transferrin complex, the rise in intralysomal pH could account for the inhibitory effect of spermine on iron uptake.	Iron	99-103	serotransferrin	Oryctolagus cuniculus	41-52
4016967-3	1985	Since intracellular release of iron from transferrin is believed to involve the protonation of the iron-transferrin complex, the rise in intralysomal pH could account for the inhibitory effect of spermine on iron uptake.	Iron	99-103	serotransferrin	Oryctolagus cuniculus	104-115
4016967-3	1985	Since intracellular release of iron from transferrin is believed to involve the protonation of the iron-transferrin complex, the rise in intralysomal pH could account for the inhibitory effect of spermine on iron uptake.	Iron	99-103	serotransferrin	Oryctolagus cuniculus	41-52
4016967-3	1985	Since intracellular release of iron from transferrin is believed to involve the protonation of the iron-transferrin complex, the rise in intralysomal pH could account for the inhibitory effect of spermine on iron uptake.	Iron	99-103	serotransferrin	Oryctolagus cuniculus	104-115
6964388-0	1982	Proximity of the substrate binding site and the heme-iron catalytic site in cytochrome P-450scc.	Iron	53-57	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	76-95
2999796-3	1985	An equal amount of unconjugated neuraminidase had no effect, and desialylation of class II antigen components was blocked when access of transferrin-neuraminidase conjugates to the B-LCL transferrin receptors was competitively inhibited by the addition of excess iron-saturated transferrin.	Iron	263-267	neuraminidase 1	Homo sapiens	149-162
6964388-1	1982	As an approach to "mapping" the active site of the cytochrome P-450 that catalyzes cholesterol side-chain cleavage, designated cytochrome P-450scc, we have synthesized steroid derivatives with the potential to interact with both the substrate binding site and the heme-iron catalytic site of the enzyme.	Iron	269-273	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	127-146
7150235-0	1982	Removal of iron from diferric rabbit serum transferrin by rabbit reticulocytes.	Iron	11-15	serotransferrin	Oryctolagus cuniculus	43-54
7150235-1	1982	When radioiron-labelled transferrin with 55Fe located predominantly in the N-terminal iron-binding site and 59Fe predominantly in the C-terminal iron-binding site was incubated with rabbit reticulocytes, both radioisotopes of iron were removed at similar rates.	Iron	10-14	serotransferrin	Oryctolagus cuniculus	24-35
7150235-2	1982	Electrophoresis of transferrin samples taken during the course of an incubation, in polyacrylamide gels containing 6 M-urea, showed that iron was removed in a pairwise fashion, giving rise to iron-free transferrin.	Iron	137-141	serotransferrin	Oryctolagus cuniculus	19-30
7150235-2	1982	Electrophoresis of transferrin samples taken during the course of an incubation, in polyacrylamide gels containing 6 M-urea, showed that iron was removed in a pairwise fashion, giving rise to iron-free transferrin.	Iron	137-141	serotransferrin	Oryctolagus cuniculus	202-213
7150235-2	1982	Electrophoresis of transferrin samples taken during the course of an incubation, in polyacrylamide gels containing 6 M-urea, showed that iron was removed in a pairwise fashion, giving rise to iron-free transferrin.	Iron	192-196	serotransferrin	Oryctolagus cuniculus	19-30
7150235-2	1982	Electrophoresis of transferrin samples taken during the course of an incubation, in polyacrylamide gels containing 6 M-urea, showed that iron was removed in a pairwise fashion, giving rise to iron-free transferrin.	Iron	192-196	serotransferrin	Oryctolagus cuniculus	202-213
3858456-11	1985	Possible mechanisms include decreased Fox activity and/or decreased iron reduction by ascorbate or XDH.	Iron	68-72	xanthine dehydrogenase	Rattus norvegicus	99-102
3994716-0	1985	Iron-57 chemical shifts in carbonyl myoglobin and its model complexes determined by iron-57-carbon-13 double resonance.	Iron	0-4	myoglobin	Physeter catodon	36-45
3994716-0	1985	Iron-57 chemical shifts in carbonyl myoglobin and its model complexes determined by iron-57-carbon-13 double resonance.	Iron	84-88	myoglobin	Physeter catodon	36-45
3970939-3	1985	This unusually low v(Fe-CO) stretching frequency in cytochrome P-450scc, compared with other CO-complexed hemoproteins such as CO-hemoglobin and -myoglobin, is presumably due to the thiolate ligation to the heme iron trans to CO and due to the linear and perpendicular configuration of CO binding to the heme.	Iron	212-216	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	63-71
2858272-9	1985	This suggests that cyclic GMP synthesis could be involved in the promotion of transformed cell growth by iron.	Iron	105-109	5'-nucleotidase, cytosolic II	Mus musculus	26-29
7115619-0	1982	Molecular aspects of the binding of absorbed iron to transferrin.	Iron	45-49	serotransferrin	Oryctolagus cuniculus	53-64
7115619-1	1982	To study the molecular aspects of the binding of absorbed iron to plasma transferrin, 59Fe with high specific activity was administered via intragastric tube to iron-deficient rabbits.	Iron	58-62	serotransferrin	Oryctolagus cuniculus	73-84
7115619-3	1982	Absorbed iron was bound to circulating transferrin one atom at a time.	Iron	9-13	serotransferrin	Oryctolagus cuniculus	39-50
7115619-5	1982	Thus, the two sites of transferrin may differ in their ability to load absorbed iron.	Iron	80-84	serotransferrin	Oryctolagus cuniculus	23-34
2981898-1	1985	Single-cell analysis of K562 human erythroleukemia cells by flow cytometry was used to demonstrate the specific role of iron in regulating transferrin receptors (TfRs) and to establish that TfR expression does not necessarily correlate with growth rate.	Iron	120-124	transferrin receptor	Homo sapiens	162-165
3971047-0	1985	Calmodulin antagonists inhibit and phorbol esters enhance transferrin endocytosis and iron uptake by immature erythroid cells.	Iron	86-90	calmodulin 1	Rattus norvegicus	0-10
2981898-3	1985	TfR expression was negatively correlated with exogenous iron content: any treatment that reduced exogenous iron supply by at least 15% resulted in as much as a 1.8-fold increase in external receptors, detected as binding by both transferrin and monoclonal anti-TfR antibodies, and a 1.5-fold increase in the pool of internal receptors, as detected by anti-TfR antibody binding.	Iron	56-60	transferrin receptor	Homo sapiens	0-3
2981898-3	1985	TfR expression was negatively correlated with exogenous iron content: any treatment that reduced exogenous iron supply by at least 15% resulted in as much as a 1.8-fold increase in external receptors, detected as binding by both transferrin and monoclonal anti-TfR antibodies, and a 1.5-fold increase in the pool of internal receptors, as detected by anti-TfR antibody binding.	Iron	107-111	transferrin receptor	Homo sapiens	0-3
3971047-1	1985	Seven antagonists of the calcium-binding protein calmodulin were found to inhibit iron and transferrin uptake by reticulocytes.	Iron	82-86	calmodulin 1	Rattus norvegicus	49-59
2981898-3	1985	TfR expression was negatively correlated with exogenous iron content: any treatment that reduced exogenous iron supply by at least 15% resulted in as much as a 1.8-fold increase in external receptors, detected as binding by both transferrin and monoclonal anti-TfR antibodies, and a 1.5-fold increase in the pool of internal receptors, as detected by anti-TfR antibody binding.	Iron	107-111	transferrin receptor	Homo sapiens	261-264
3971047-5	1985	Since these substances are known to stimulate the calcium-activated enzyme protein kinase C while calmodulin antagonists are inhibitory, it is concluded that this enzyme plays an important role in the endocytosis and intracellular cycling of transferrin, and iron uptake by immature erythroid cells.	Iron	259-263	calmodulin 1	Rattus norvegicus	98-108
2981898-3	1985	TfR expression was negatively correlated with exogenous iron content: any treatment that reduced exogenous iron supply by at least 15% resulted in as much as a 1.8-fold increase in external receptors, detected as binding by both transferrin and monoclonal anti-TfR antibodies, and a 1.5-fold increase in the pool of internal receptors, as detected by anti-TfR antibody binding.	Iron	107-111	transferrin receptor	Homo sapiens	261-264
6282659-4	1982	PAH also requires 1.0 iron per 50,000-dalton subunit for maximal activity.	Iron	22-26	phenylalanine hydroxylase	Homo sapiens	0-3
2940809-2	1985	Studies on different types of iron and its relation with porphyrinogen carboxy-lyase decrease.	Iron	30-34	uroporphyrinogen decarboxylase	Rattus norvegicus	57-84
7050653-5	1982	A complex set of factors govern the sequential protein-protein interactions which comprise this adrenodoxin shuttle mechanism; among these factors, reduction of the iron sulfur center by the flavin weakens the adrenodoxin-adrenodoxin reductase interaction, thus promoting dissociation of this complex to yield free reduced adrenodoxin.	Iron	165-169	ferredoxin reductase	Homo sapiens	222-243
6277636-1	1982	A possible correlation between Rieske"s iron-sulfur cluster and cytochrome b.	Iron	40-44	cytochrome b	Saccharomyces cerevisiae S288C	64-76
2982885-7	1985	This pathway, which has not been previously described for a cell surface receptor, may be different from the route followed by TfR in iron uptake, since reported rates of transferrin uptake and release are significantly more rapid than the resialylation of asialo-TfR.	Iron	134-138	transferrin receptor	Homo sapiens	127-130
2409306-3	1985	For "iron-sufficient conditions", Fe(II) was added to reaction mixtures to attain the molar ratio of bleomycin/iron at 1/1 to 1/29.	Iron	5-9	angiotensin II receptor type 1	Homo sapiens	116-130
2409306-3	1985	For "iron-sufficient conditions", Fe(II) was added to reaction mixtures to attain the molar ratio of bleomycin/iron at 1/1 to 1/29.	Iron	111-115	angiotensin II receptor type 1	Homo sapiens	116-130
7054185-2	1982	Phenylalanine hydroxylase requires 1.0 mol of iron/Mr = 50,000 subunit for maximal activity.	Iron	46-50	phenylalanine hydroxylase	Homo sapiens	0-25
2940809-5	1985	Enzymic preparations of porphyric livers filtered through Sephadex G-25 columns which separate the free iron and that has a content of iron-protein greater than those in normals, exhibited a strong inhibition of PCL.	Iron	104-108	uroporphyrinogen decarboxylase	Rattus norvegicus	212-215
2940809-5	1985	Enzymic preparations of porphyric livers filtered through Sephadex G-25 columns which separate the free iron and that has a content of iron-protein greater than those in normals, exhibited a strong inhibition of PCL.	Iron	135-139	uroporphyrinogen decarboxylase	Rattus norvegicus	212-215
2940809-8	1985	So, it could be observed that inorganic iron and haemin produce slight inhibition of PCL when added in concentrations higher than those corresponding to a porphyric liver (0.08 mM and 10(-6) M, respectively, as mean in the incubation media).	Iron	40-44	uroporphyrinogen decarboxylase	Rattus norvegicus	85-88
3855550-1	1985	We have determined the complete primary structure of human hemopexin, a plasma beta-glycoprotein that specifically binds one heme with high affinity and transports it to hepatocytes for salvage of the iron.	Iron	201-205	hemopexin	Homo sapiens	59-68
6246947-16	1980	On the basis of these studies we propose that transferrin is first bound to a membrane protein and then delivers iron to a membrane component distinct and separate from the transferrin-binding moiety.	Iron	113-117	serotransferrin	Oryctolagus cuniculus	46-57
6246947-17	1980	Prior to its release, transferrin markedly depleted of iron is still bound to a component in the plasma membrane.	Iron	55-59	serotransferrin	Oryctolagus cuniculus	22-33
6541651-4	1984	We have found that the ligation of exogenous thiols to the heme iron of chloroperoxidase generates hyperporphyrin (split Soret) spectra (lambda max = approximately 372 and approximately 455 nm), consistent with the formation of bisthiolate low-spin ferric heme adducts as has been established for P-450 and its heme models.	Iron	64-68	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	297-302
7188938-0	1980	Iron binding by phosvitin and its conformational consequences.	Iron	0-4	casein kinase 2 beta	Homo sapiens	16-25
7188938-1	1980	With a view to the potential biological significance of iron binding by the phosphoprotein phosvitin, the interaction of these two electrostatically complementary constituents of egg yolk particles was studied by ultrafiltration, circular dichroism, and sedimentation.	Iron	56-60	casein kinase 2 beta	Homo sapiens	91-100
7188938-3	1980	When saturated, pairs of the approximately 135 phosphate groups of a phosvitin molecule appear to bind 1 iron atom each.	Iron	105-109	casein kinase 2 beta	Homo sapiens	69-78
7188938-8	1980	Nevertheless, iron affects phosvitin structure.	Iron	14-18	casein kinase 2 beta	Homo sapiens	27-36
7188938-10	1980	Near pH 2, where the beta-type conformation is readily acquired by the protein in the absence of iron, the consequences of iron binding upon conformation are determined by the manner in which the iron-phosvitin interaction is brought about.	Iron	97-101	casein kinase 2 beta	Homo sapiens	201-210
7188938-10	1980	Near pH 2, where the beta-type conformation is readily acquired by the protein in the absence of iron, the consequences of iron binding upon conformation are determined by the manner in which the iron-phosvitin interaction is brought about.	Iron	123-127	casein kinase 2 beta	Homo sapiens	201-210
7188938-10	1980	Near pH 2, where the beta-type conformation is readily acquired by the protein in the absence of iron, the consequences of iron binding upon conformation are determined by the manner in which the iron-phosvitin interaction is brought about.	Iron	123-127	casein kinase 2 beta	Homo sapiens	201-210
465681-1	1979	A rise of hemoglobin concentration accompanied by an increase of the total iron in the blood serum of white mice was found under oxygen pressure of 4 atm for an hour (preconvulsive state) and 6 atm (convulsive state).	Iron	75-79	ataxia telangiectasia mutated	Mus musculus	150-153
465681-1	1979	A rise of hemoglobin concentration accompanied by an increase of the total iron in the blood serum of white mice was found under oxygen pressure of 4 atm for an hour (preconvulsive state) and 6 atm (convulsive state).	Iron	75-79	ataxia telangiectasia mutated	Mus musculus	194-197
427687-8	1979	Porphyria cutanea tarda, which is due to a deficiency of uroporphyrinogen decarboxylase, is manifested in association with alcohol abuse, estrogen therapy, exposure to chlorinated hydrocarbons or increased tissue iron stores, or a combination of these factors.	Iron	213-217	uroporphyrinogen decarboxylase	Homo sapiens	57-87
154160-2	1978	ATP synthesis would take place on a catalytic site of ATPase constituted by two irons with ligands ATP, ADP, and Pi.	Iron	80-85	dynein axonemal heavy chain 8	Homo sapiens	54-60
281251-0	1978	Use of iron from transferrin and microbial chelates as substrate for heme synthetase in transformed and primary erythroid cell cultures.	Iron	7-11	serotransferrin	Oryctolagus cuniculus	17-28
208602-7	1978	The change in the apparent ligand capacity of a region near the heme iron in response to energization is evidence for an interaction between cytochrome oxidase and the ATPase system.	Iron	69-73	dynein axonemal heavy chain 8	Homo sapiens	168-174
661761-0	1978	[Study of the relation between blood iron and HbA2 synthesis in infants].	Iron	37-41	hemoglobin subunit alpha 2	Homo sapiens	46-50
664035-2	1978	A molecule of P. vitale catalase is determined to contain 0.051 +/- 0.0003% of iron.	Iron	79-83	catalase	Bos taurus	24-32
664035-3	1978	It corresponds to two iron atoms per enzyme molecule and to a twice as low content of iron as in a molecule of the bovine liver catalase.	Iron	22-26	catalase	Bos taurus	128-136
664035-3	1978	It corresponds to two iron atoms per enzyme molecule and to a twice as low content of iron as in a molecule of the bovine liver catalase.	Iron	86-90	catalase	Bos taurus	128-136
901911-5	1977	A comparison with earlier investigations on myoglobin and haemoglobin indicates that the electronic structure of iron in the HbHp-complexes is similar to that in myoglobin.	Iron	113-117	hemoglobin subunit alpha 1	Homo sapiens	125-129
588476-6	1977	Transferrin, 80% saturated with iron, was bound to a greater extent than 10 or 50% saturated transferrin; 10% saturated transferrin was bound more readily than the 50% saturated preparation.	Iron	32-36	serotransferrin	Oryctolagus cuniculus	0-11
588476-7	1977	The findings are consistent with the presence of a transferrin receptor on the cell membrane of the alveolar macrophage and imply that transferrin may interact directly with this cell type in order to remove or donate iron.	Iron	218-222	serotransferrin	Oryctolagus cuniculus	51-62
588476-7	1977	The findings are consistent with the presence of a transferrin receptor on the cell membrane of the alveolar macrophage and imply that transferrin may interact directly with this cell type in order to remove or donate iron.	Iron	218-222	serotransferrin	Oryctolagus cuniculus	135-146
21981-4	1977	The ascorbic acid plus Fe++-stimulated lipid peroxidation produced a decrease in ethylmorphine N-demethylase activity which was closely related to ethylmorphine-enhanced NADPH-cytochrome P-450 reductase activity but was not related to the change of the apparent content of cytochrome P-450 in all animal species.	Iron	23-27	cytochrome P-450	Oryctolagus cuniculus	176-192
143816-1	1977	The EFG-tensor at the position of the Fe-atom of CO-liganded sperm whale myoglobin has been investigated by nuclear gamma-resonance absorption experiments on single crystals.	Iron	38-40	myoglobin	Physeter catodon	73-82
976191-0	1976	The interrelation of renin and iron binding capacity.	Iron	31-35	renin	Rattus norvegicus	21-26
976191-2	1976	The current experiments were designed to determine if a decrease in iron stores is the stimulus for renin production when rats are rapidly expanding their red cell volume in a hypoxic environment.	Iron	68-72	renin	Rattus norvegicus	100-105
976191-7	1976	Rats that were fed the low iron diet showed an increase in TIBC, an increase in serum renin and a positive correlation between serum renin and TIBC.	Iron	27-31	renin	Rattus norvegicus	86-91
976191-7	1976	Rats that were fed the low iron diet showed an increase in TIBC, an increase in serum renin and a positive correlation between serum renin and TIBC.	Iron	27-31	renin	Rattus norvegicus	133-138
976191-9	1976	When low iron diet rats were supplemented with iron, TIBC and serum renin decreased.	Iron	9-13	renin	Rattus norvegicus	68-73
976191-9	1976	When low iron diet rats were supplemented with iron, TIBC and serum renin decreased.	Iron	47-51	renin	Rattus norvegicus	68-73
184834-4	1976	Similarly high rates were measured in a deuterated solution using the aliphatic protons of glycerol as stereochemical markers, which strongly suggests that the haem iron in cytochrome P-450 is much more accessible to the solvent than in harmoglobin or myoglobin.	Iron	165-169	cytochrome P-450	Oryctolagus cuniculus	173-189
1061127-5	1976	The infrared stretching frequencies of ferrous porphyrin carbonyl complexes and the absorption spectrum of the CO adduct of Na[Fe1(meso-tetraphenylporphyrin dianion)] are consistent with the concept that in P-450 considerable electron density is transferred to the iron by the mercaptide ligand.	Iron	265-269	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	207-212
1222226-0	1975	Relationship between Hb and HbA2 concentrations in untreated and Fe-treated iron deficiency anaemia.	Iron	65-67	hemoglobin subunit alpha 2	Homo sapiens	28-32
1222226-2	1975	15 days after a month course of iron therapy the mean percentage increase of HbA2 was greater (123.9%) than that of Hb (62.0%).	Iron	32-36	hemoglobin subunit alpha 2	Homo sapiens	77-81
1168084-0	1975	Relationship between Hb and HbA2 concentrations in healthy and iron deficient subjects.	Iron	63-67	hemoglobin subunit alpha 2	Homo sapiens	28-32
1168084-6	1975	Shortness of iron seems to reduce more the HbA2 than the Hb levels.	Iron	13-17	hemoglobin subunit alpha 2	Homo sapiens	43-47
4100308-2	1971	This distinctive reaction is characteristic of a coordination complex with heme iron, and is ascribed to a remarkable affinity for heme of certain plasma glycoglobulins, which include hemopexin.	Iron	80-84	hemopexin	Homo sapiens	184-193
24174153-8	1970	Enzymatic digestion of living cells revealed that both trypsin and neuraminidase reduced the staining of the cell coat by colloidal iron, whereas only trypsin altered its staining with ruthenium red.	Iron	132-136	neuraminidase 1	Homo sapiens	67-80
4318775-4	1970	It is suggested that microsomal cytochrome P-450 can exist in two interconvertible forms, in which the heme iron can either be high-spin or low-spin, depending upon the nature of the nonporphyrin ligands of the metal.	Iron	108-112	cytochrome P-450	Oryctolagus cuniculus	32-48
4987798-0	1970	The effect of transferrin-free serum on the utilization of iron by rabbit reticulocytes.	Iron	59-63	serotransferrin	Oryctolagus cuniculus	14-25
4980107-0	1969	The role of iron in the reaction between rabbit transferrin and reticulocytes.	Iron	12-16	serotransferrin	Oryctolagus cuniculus	48-59
5780000-0	1969	Iron and copper effects on serum ceruloplasmin activity of rats with zinc-induced copper deficiency.	Iron	0-4	ceruloplasmin	Rattus norvegicus	33-46
6029610-9	1967	The xanthine-dehydrogenase activity is unchanged after addition of orotic acid to the diet, and is stimulated by injection of inorganic iron.	Iron	136-140	xanthine dehydrogenase	Gallus gallus	4-26
33901579-0	2021	Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2alpha/ATF4/CHOP pathway in vitro.	Iron	0-4	eukaryotic translation initiation factor 2A	Mus musculus	117-126
33901579-11	2021	In conclusion, our finding suggested that iron overload induced apoptosis via eliciting ER stress, which resulted in mitochondrial dysfunction and activated p-eIF2alpha/ATF4/CHOP pathway.	Iron	42-46	eukaryotic translation initiation factor 2A	Mus musculus	159-168
34034877-0	2021	Iron deficiency-induced transcription factors bHLH38/100/101 negatively modulate flowering time in Arabidopsis thaliana.	Iron	0-4	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	46-60
3939136-1	1985	Doxorubicin semiquinone, produced by reduction of doxorubicin with xanthine oxidase or ferredoxin reductase, reacted with H2O2 to cause deoxyribose oxidation that was catalysed by sub-micromolar concentrations of complexed iron.	Iron	223-227	ferredoxin reductase	Homo sapiens	87-107
6489695-0	1984	Dual mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron: its potential role in the genesis of porphyria cutanea tarda.	Iron	85-97	uroporphyrinogen decarboxylase	Rattus norvegicus	42-72
6489695-1	1984	Hepatic iron overload amplifies the uroporphyrinogen decarboxylase enzyme defect in human porphyria cutanea tarda.	Iron	8-12	uroporphyrinogen decarboxylase	Rattus norvegicus	36-66
6511679-1	1984	Levels of lactoferrin, an Fe-binding protein with bacteriostatic properties, were determined in the colostrum and milk of Yorkshire sows during a 21-d lactation.	Iron	26-28	lactotransferrin	Sus scrofa	10-21
6387606-7	1984	Uptake of intravenously injected transferrin-bound iron into muscle of vitamin E-deficient rabbits was not increased in a short term experiment (6 h), but radioiron did accumulate in muscle in a long term experiment (6 days).	Iron	51-55	serotransferrin	Oryctolagus cuniculus	33-44
6088552-2	1984	In contrast, cells grown in the presence of protoporphyrin IX or picolinic acid (an iron chelator) exhibited a marked increase in Trf binding.	Iron	84-88	interleukin 5	Homo sapiens	130-133
6088552-5	1984	Investigation of the Trf receptors" turnover and biosynthesis clearly showed that iron and hemin decreased the synthesis of Trf receptors without any modification of the receptor turnover; in contrast, protoporphyrin IX and picolinic acid markedly increased the synthesis of Trf receptors.	Iron	82-86	interleukin 5	Homo sapiens	21-24
6088552-5	1984	Investigation of the Trf receptors" turnover and biosynthesis clearly showed that iron and hemin decreased the synthesis of Trf receptors without any modification of the receptor turnover; in contrast, protoporphyrin IX and picolinic acid markedly increased the synthesis of Trf receptors.	Iron	82-86	interleukin 5	Homo sapiens	124-127
6088552-5	1984	Investigation of the Trf receptors" turnover and biosynthesis clearly showed that iron and hemin decreased the synthesis of Trf receptors without any modification of the receptor turnover; in contrast, protoporphyrin IX and picolinic acid markedly increased the synthesis of Trf receptors.	Iron	82-86	interleukin 5	Homo sapiens	124-127
6088552-6	1984	Our results suggest that hemin, iron, and protoporphyrin IX may represent the main molecules involved in the regulation of Trf receptors.	Iron	32-36	interleukin 5	Homo sapiens	123-126
6498623-5	1984	Iron or cobalt in a 10-fold molar excess predominantly lowered 65Zn transfer in both sla and controls, but in a study of the effect of zinc on iron transport only the uptake of 59Fe in sla mice was lowered by excess zinc in the perfusate.	Iron	0-4	hephaestin	Mus musculus	85-88
6498623-5	1984	Iron or cobalt in a 10-fold molar excess predominantly lowered 65Zn transfer in both sla and controls, but in a study of the effect of zinc on iron transport only the uptake of 59Fe in sla mice was lowered by excess zinc in the perfusate.	Iron	0-4	hephaestin	Mus musculus	185-188
24264114-2	1984	In rabbit reticulocytes more than 50% of the transferrin-donated nonheme iron proved to be divalent.	Iron	73-77	serotransferrin	Oryctolagus cuniculus	45-56
33988981-7	2021	For the first time, we present a cocrystal structure of SAMHD1 with a substrate, Rp-dGTPalphaS, in which an Fe-Mg-bridging water species is poised for nucleophilic attack on the Palpha.	Iron	108-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	56-62
33179561-0	2021	Salivary cystatin SN is a factor predicting iron bioavailability after phytic acid rich meals in female participants.	Iron	44-48	cystatin SN	Homo sapiens	9-20
6505627-0	1984	Iron overload and lysosomal stability in beta zero-thalassaemia intermedia and trait: correlation between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels.	Iron	0-4	O-GlcNAcase	Homo sapiens	131-162
33179561-2	2021	This study evaluated the relationship between human cystatin SN levels and iron bioavailability after a phytic acid rich meal.	Iron	75-79	cystatin SN	Homo sapiens	52-63
33179561-5	2021	Pre-to-post meal cystatin SN was positively correlated with improved iron bioavailability in group 1.	Iron	69-73	cystatin SN	Homo sapiens	17-28
33179561-6	2021	Pre-to-post meal cystatin SN was correlated with improved iron absorption in groups 1 and 2.	Iron	58-62	cystatin SN	Homo sapiens	17-28
33179561-7	2021	Cystatin SN recovery after phytic acid rich meals may be a physiological factor predicting iron bioavailability.	Iron	91-95	cystatin SN	Homo sapiens	0-11
34029365-4	2021	show that like central carbon metabolism, iron metabolism is also closely implicated in autophagy-mediated life extension via the TORC2 activator Ypk1p and the iron regulator Aft1p.	Iron	42-46	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	146-151
34048062-2	2021	Genetic causes of high liver iron include homozygosity for the p.Cys282Tyr variant in HFE and rare variants in non-HFE genes.	Iron	29-33	homeostatic iron regulator	Homo sapiens	86-89
34048062-2	2021	Genetic causes of high liver iron include homozygosity for the p.Cys282Tyr variant in HFE and rare variants in non-HFE genes.	Iron	29-33	homeostatic iron regulator	Homo sapiens	115-118
34048062-10	2021	CONCLUSIONS: In patients without homozygosity for p.Cys282Tyr, coincident pathogenic variants in HFE and non-HFE genes could explain hyperferritinemia with hepatic iron overload in a subset of patients.	Iron	164-168	homeostatic iron regulator	Homo sapiens	97-100
34051234-0	2021	Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14.	Iron	28-32	solute carrier family 39 (zinc transporter), member 14	Mus musculus	76-84
34051234-0	2021	Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14.	Iron	61-65	solute carrier family 39 (zinc transporter), member 14	Mus musculus	76-84
34051234-4	2021	Here we investigated the role of metal transporters SLC39A14 and SLC30A10 in biliary iron excretion.	Iron	85-89	solute carrier family 39 (zinc transporter), member 14	Mus musculus	52-60
34051234-5	2021	While SLC39A14 imports manganese into the liver and other organs under physiological conditions, it imports iron under conditions of iron excess.	Iron	108-112	solute carrier family 39 (zinc transporter), member 14	Mus musculus	6-14
34051234-5	2021	While SLC39A14 imports manganese into the liver and other organs under physiological conditions, it imports iron under conditions of iron excess.	Iron	133-137	solute carrier family 39 (zinc transporter), member 14	Mus musculus	6-14
34051234-7	2021	We hypothesized that biliary excretion of excess iron would be impaired by SLC39A14 and SLC30A10 deficiency.	Iron	49-53	solute carrier family 39 (zinc transporter), member 14	Mus musculus	75-83
34051234-10	2021	Our results support a model in which biliary excretion of excess iron requires iron import into hepatocytes by SLC39A14, followed by iron export into bile predominantly as ferritin, with iron export occurring independently of SLC30A10.	Iron	65-69	solute carrier family 39 (zinc transporter), member 14	Mus musculus	111-119
34051234-10	2021	Our results support a model in which biliary excretion of excess iron requires iron import into hepatocytes by SLC39A14, followed by iron export into bile predominantly as ferritin, with iron export occurring independently of SLC30A10.	Iron	79-83	solute carrier family 39 (zinc transporter), member 14	Mus musculus	111-119
34051234-10	2021	Our results support a model in which biliary excretion of excess iron requires iron import into hepatocytes by SLC39A14, followed by iron export into bile predominantly as ferritin, with iron export occurring independently of SLC30A10.	Iron	79-83	solute carrier family 39 (zinc transporter), member 14	Mus musculus	111-119
34051234-10	2021	Our results support a model in which biliary excretion of excess iron requires iron import into hepatocytes by SLC39A14, followed by iron export into bile predominantly as ferritin, with iron export occurring independently of SLC30A10.	Iron	79-83	solute carrier family 39 (zinc transporter), member 14	Mus musculus	111-119
34018302-0	2021	The phyB-dependent induction of HY5 promotes iron uptake by systemically activating FER expression.	Iron	45-49	bHLH transcriptional regulator	Solanum lycopersicum	84-87
34018302-5	2021	HY5 movement from shoots to roots activates the expression of FER transcription factor, leading to the accumulation of transcripts involved in Fe uptake.	Iron	143-145	bHLH transcriptional regulator	Solanum lycopersicum	62-65
34018302-6	2021	Mutation in FER abolishes the light quality-induced changes in Fe uptake.	Iron	63-65	bHLH transcriptional regulator	Solanum lycopersicum	12-15
34018302-7	2021	The low Fe uptake observed in phyB, hy5, and fer mutants is accompanied by lower photosynthetic electron transport rates.	Iron	8-10	bHLH transcriptional regulator	Solanum lycopersicum	45-48
34018302-9	2021	Taken together, these results demonstrate that Fe uptake is systemically regulated by light in a phyB-HY5-FER-dependent manner.	Iron	47-49	bHLH transcriptional regulator	Solanum lycopersicum	106-109
34046211-2	2021	Frataxin functions in the process of iron-sulfur (Fe-S) cluster synthesis.	Iron	50-54	frataxin	Homo sapiens	0-8
33982327-2	2021	Growth factors, such as BMP2, BMP6 and TGFbeta1, are released from liver sinusoidal endothelial cells (LSECs) and signal in a paracrine manner to hepatocytes and hepatic stellate cells to control systemic iron homeostasis and fibrotic processes, respectively.	Iron	205-209	transforming growth factor, beta 1	Mus musculus	39-47
33982327-9	2021	CONCLUSIONS: These findings reveal that TGFbeta1 signalling is functionally interlinked with BMP signalling in LSECs suggesting new druggable targets for the treatment of iron overload diseases associated with deficiency of the BMP2-regulated hormone hepcidin, such as Hereditary Hemochromatosis, beta-thalassemia and chronic liver diseases.	Iron	171-175	transforming growth factor, beta 1	Mus musculus	40-48
33934496-0	2021	Influences of pH and substrate supply on the ratio of iron to sulfate reduction.	Iron	54-58	phenylalanine hydroxylase	Homo sapiens	14-16
33524530-1	2021	Previous reports revealed that mutation of mitochondrial inner-membrane located protein SFXN1 led to pleiotropic hematological and skeletal defects in mice, associated with the presence of hypochromic erythroid cell, iron overload in mitochondrion of erythroblast and the development of sideroblastic anemia (SA).	Iron	217-221	sideroflexin 1	Mus musculus	88-93
33580994-4	2021	The results showed that ergothioneine inhibited iron-evoked inflammation and apoptosis as demonstrated by a significant reduction in tumor necrosis factor-alpha and interleukin-6 levels and in caspase-3 activity.	Iron	48-52	caspase 3	Rattus norvegicus	193-202
33951329-1	2021	Friedreich ataxia is an autosomal recessive, neurodegenerative disease characterized by the deficiency of the iron-sulfur cluster assembly protein frataxin.	Iron	110-114	frataxin	Homo sapiens	147-155
33583065-0	2021	Inactivation of cytosolic FUMARASE2 enhances growth and photosynthesis under simultaneous copper and iron deprivation in Arabidopsis.	Iron	101-105	FUMARASE 2	Arabidopsis thaliana	26-35
33583065-5	2021	In fum2 mutants, photosynthesis and growth were less impaired under -Cu-Fe conditions than in wild-type (WT) seedlings.	Iron	72-74	FUMARASE 2	Arabidopsis thaliana	3-7
33925597-4	2021	Dietary iron is taken up by the divalent metal transporter 1 (DMT1) in enterocytes and transported to portal blood via ferroportin (FPN), where it is bound to transferrin and taken up by hepatocytes, macrophages and bone marrow cells via transferrin receptor 1 (TfR1).	Iron	8-12	transferrin receptor	Homo sapiens	238-260
33925597-4	2021	Dietary iron is taken up by the divalent metal transporter 1 (DMT1) in enterocytes and transported to portal blood via ferroportin (FPN), where it is bound to transferrin and taken up by hepatocytes, macrophages and bone marrow cells via transferrin receptor 1 (TfR1).	Iron	8-12	transferrin receptor	Homo sapiens	262-266
33894270-8	2021	Prdx6 overexpression also eliminated ferroptosis caused by HG, which was reflected in the suppression of iron accumulation and the increase in SLC7A11 and GPX4 expression.	Iron	105-109	peroxiredoxin 6	Mus musculus	0-5
33906007-2	2021	BoHV-1 infection provokes an increase in ferritin levels and a decrease of transferrin receptor 1 (TfR-1) expression, ultimately lowering iron pool extent.	Iron	138-142	transferrin receptor	Homo sapiens	99-104
33981582-3	2021	As the fusion protein contains an entire IgG1 molecule that binds TfR, there may be specific safety concerns, such as unexpected cellular toxicity due to its effector functions or its ability to inhibit iron metabolism, in addition to general safety concerns.	Iron	203-207	transferrin receptor	Homo sapiens	66-69
33863873-5	2021	Moreover, YAP increased the iron concentration in HCC cells through transcriptional elevation of TFRC via its O-GlcNAcylation.	Iron	28-32	Yes1 associated transcriptional regulator	Homo sapiens	10-13
33863873-5	2021	Moreover, YAP increased the iron concentration in HCC cells through transcriptional elevation of TFRC via its O-GlcNAcylation.	Iron	28-32	transferrin receptor	Homo sapiens	97-101
33997705-5	2021	Apoferritin inhibited MPTP-induced iron aggregation by down-regulating iron importer divalent metal transporter 1 (DMT1).	Iron	35-39	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	85-113
33997705-5	2021	Apoferritin inhibited MPTP-induced iron aggregation by down-regulating iron importer divalent metal transporter 1 (DMT1).	Iron	35-39	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	115-119
33917391-9	2021	In both cell lines, we demonstrated an increased expression of transferrin receptor 1 (TFR1) and ferritin in MCD serum-treated cells as compared to controls, suggesting increased iron demand.	Iron	179-183	transferrin receptor	Homo sapiens	63-85
33917391-9	2021	In both cell lines, we demonstrated an increased expression of transferrin receptor 1 (TFR1) and ferritin in MCD serum-treated cells as compared to controls, suggesting increased iron demand.	Iron	179-183	transferrin receptor	Homo sapiens	87-91
33917391-10	2021	Furthermore, we related TFR1 expression with the clinical profile of patients and showed that greater iron demand in sera-treated cells was associated with higher inflammation score (interleukin 6 (IL-6), C-reactive protein (CRP)) and advanced neurohormonal activation (NT-proBNP) in patients.	Iron	102-106	transferrin receptor	Homo sapiens	24-28
33483374-4	2021	Namely, amplified MYCN rewired the cell through expression of key receptors, ultimately enhancing iron influx through increased expression of the iron import transferrin receptor 1 (TfR1).	Iron	98-102	transferrin receptor	Homo sapiens	158-180
33483374-4	2021	Namely, amplified MYCN rewired the cell through expression of key receptors, ultimately enhancing iron influx through increased expression of the iron import transferrin receptor 1 (TfR1).	Iron	98-102	transferrin receptor	Homo sapiens	182-186
33483374-4	2021	Namely, amplified MYCN rewired the cell through expression of key receptors, ultimately enhancing iron influx through increased expression of the iron import transferrin receptor 1 (TfR1).	Iron	146-150	transferrin receptor	Homo sapiens	158-180
33483374-4	2021	Namely, amplified MYCN rewired the cell through expression of key receptors, ultimately enhancing iron influx through increased expression of the iron import transferrin receptor 1 (TfR1).	Iron	146-150	transferrin receptor	Homo sapiens	182-186
33097833-4	2021	Mechanistically, ferroptosis inducers (erastin, sorafenib, and sulfasalazine) activated AMPK/SREBP1 signaling pathway through iron-dependent ferritinophagy, which in turn inhibited BCAT2 transcription.	Iron	126-130	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	88-92
33865246-7	2021	RESULTS: In this study, Shine and Lal, Ehsani, Telissani, Sirachainan, Hisham, Kandhro 2, and Mantos indexes showed 100% sensitivity, specificity, Youden"s index, and 1.00 AUC for differentiating alpha thalassemia from iron deficient group.	Iron	219-223	lipase A, lysosomal acid type	Homo sapiens	34-37
33931967-9	2021	USP35 overexpression did not affect tumorigenesis and ferroptosis under basal conditions, but reduced erastin/RSL3-triggered iron disturbance and ferroptosis, thereby facilitating lung cancer cell growth and tumor progression.	Iron	125-129	ubiquitin specific peptidase 35	Homo sapiens	0-5
33649797-9	2021	Mechanistically, miR-335 enhanced ferroptosis through the degradation of FTH1 to increase iron release, lipid peroxidation and reactive oxygen species (ROS) accumulation, and to decrease mitochondrial membrane potential (MMP).	Iron	90-94	microRNA 335	Homo sapiens	17-24
33443215-0	2021	Spinal NR2B phosphorylation at Tyr1472 regulates IRE(-)DMT1-mediated iron accumulation and spine morphogenesis via kalirin-7 in tibial fracture-associated postoperative pain after orthopedic surgery in female mice.	Iron	69-73	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	55-59
33443215-3	2021	Divalent metal transporter 1 (DMT1)-mediated iron overload involves NMDA-induced neurotoxicity in males.	Iron	45-49	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-28
33443215-10	2021	Kalirin-7 knockdown impairs fracture-associated allodynia, IRE (-) DMT1-mediated iron overload and spine plasticity.	Iron	81-85	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	67-71
33443215-13	2021	CONCLUSION: Spinal NR2B phosphorylation at Tyr1472 upregulates kalirin-7 expression to facilitate IRE (-) DMT1-mediated iron accumulation and spine morphogenesis in the development of fracture-associated postoperative pain in female mice.	Iron	120-124	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	106-110
6746749-4	1984	Treatment of the cells with lysosomotrophic agents, metabolic inhibitors, and ionophores elevated the intravesicular pH and inhibited iron uptake from transferrin.	Iron	134-138	serotransferrin	Oryctolagus cuniculus	151-162
6746749-6	1984	At pH 5.4 iron release from rabbit iron-bicarbonate transferrin in vitro was much more rapid than from iron-oxalate transferrin.	Iron	10-14	serotransferrin	Oryctolagus cuniculus	52-63
6746749-6	1984	At pH 5.4 iron release from rabbit iron-bicarbonate transferrin in vitro was much more rapid than from iron-oxalate transferrin.	Iron	35-39	serotransferrin	Oryctolagus cuniculus	52-63
6746749-8	1984	It is concluded that the acidic conditions within the vesicles provide the mechanism for iron release from the transferrin molecule after its endocytosis and that the low vesicular pH is dependent on cellular metabolism.	Iron	89-93	serotransferrin	Oryctolagus cuniculus	111-122
6733115-1	1984	Temperature-dependent spin changes of the heme iron atom on cytochrome P-450scc were studied by optical absorption and circular dichroism measurements.	Iron	47-51	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	60-79
6327677-16	1984	These results suggest either that a myxothiazol-induced conformational change in cytochrome b is transmitted to a quinone binding site on the iron-sulfur protein, or that there is a quinone binding site which consists of peptide domains from both cytochrome b and iron-sulfur protein.	Iron	142-146	cytochrome b	Saccharomyces cerevisiae S288C	81-93
6327677-16	1984	These results suggest either that a myxothiazol-induced conformational change in cytochrome b is transmitted to a quinone binding site on the iron-sulfur protein, or that there is a quinone binding site which consists of peptide domains from both cytochrome b and iron-sulfur protein.	Iron	264-268	cytochrome b	Saccharomyces cerevisiae S288C	81-93
6327680-3	1984	Depletion of contaminating iron in the incubation systems resulted in small or negligible rates of cytochrome P-450-dependent ethanol oxidation.	Iron	27-31	cytochrome P-450	Oryctolagus cuniculus	99-115
6327680-4	1984	However, small amounts (1 microM) of chelated iron (e.g. Fe3+-EDTA) enhanced ethanol oxidation specifically when membranes containing the ethanol and benzene-inducible form of cytochrome P-450 (cytochrome P-450 LMeb ) were used.	Iron	46-50	cytochrome P-450	Oryctolagus cuniculus	176-192
6327680-4	1984	However, small amounts (1 microM) of chelated iron (e.g. Fe3+-EDTA) enhanced ethanol oxidation specifically when membranes containing the ethanol and benzene-inducible form of cytochrome P-450 (cytochrome P-450 LMeb ) were used.	Iron	46-50	cytochrome P-450	Oryctolagus cuniculus	194-210
6327680-6	1984	In iron-depleted systems containing cytochrome P-450 LM2 or cytochrome P-450 LMeb , an appropriate stoichiometry was attained between the NADPH consumed and the sum of hydrogen peroxide and acetaldehyde produced.	Iron	3-7	cytochrome P-450	Oryctolagus cuniculus	36-52
6713625-5	1984	In acute myocardial infarction, the concentrations of copper, zinc, and iron were higher after 21-30 h (as compared with the values at 0-10 h), by which time concentrations of calcium, magnesium, cobalt, and alanine aminotransferase had decreased.	Iron	72-76	glutamic--pyruvic transaminase	Homo sapiens	208-232
6202430-2	1984	The metabolites of benzene produced in bone marrow cells by the microsomal cytochrome P-450 are thought to be phenol, catechol, hydroquinone and p-benzoquinone (Andrews et al., Life Sci., 25 (1979) 567; Irons et al., Chem.-Biol.	Iron	203-208	cytochrome P-450	Oryctolagus cuniculus	75-91
6711003-1	1984	By use of modern methods in clinical chemistry many parameters can be selected which aid in diagnosing disturbances in iron metabolism.	Iron	119-123	activation induced cytidine deaminase	Homo sapiens	85-88
6326658-3	1984	The gene for TF therefore maps to the same region as the gene for transferrin receptor (TFR) thereby defining an iron transport region on 3q2 to which the transferrin-related tumor associated antigen p97 may also belong.	Iron	113-117	transferrin receptor	Homo sapiens	66-86
6315070-3	1983	Superoxide generated either by adriamycin:ferredoxin reductase or by hypoxanthine:xanthine oxidase can promote the formation of hydroxyl radicals in the presence of soluble iron chelates.	Iron	173-177	ferredoxin reductase	Homo sapiens	42-62
6639671-3	1983	Accordingly, acute dietary iron deprivation is found to result in a marked decrease in I-P-450 content and activity.	Iron	27-31	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-94
6639671-5	1983	We investigated the mechanistic basis for such acute reduction and report that iron was not only required as a co-substrate for I-P-450 heme formation, but also as a regulator of two key heme-synthetic enzymes, delta-aminolevulinic acid synthetase and ferrochelatase.	Iron	79-83	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	128-135
6882755-1	1983	The mechanism by which bipyridine and phenanthroline types of iron chelator inhibit iron uptake from transferrin and iron efflux mediated by pyridoxal isonicotinoyl hydrazone was investigated using rabbit reticulocytes with the aim of providing more information on the normal process of iron uptake by developing erythroid cells.	Iron	62-66	serotransferrin	Oryctolagus cuniculus	101-112
6882755-1	1983	The mechanism by which bipyridine and phenanthroline types of iron chelator inhibit iron uptake from transferrin and iron efflux mediated by pyridoxal isonicotinoyl hydrazone was investigated using rabbit reticulocytes with the aim of providing more information on the normal process of iron uptake by developing erythroid cells.	Iron	84-88	serotransferrin	Oryctolagus cuniculus	101-112
6882755-1	1983	The mechanism by which bipyridine and phenanthroline types of iron chelator inhibit iron uptake from transferrin and iron efflux mediated by pyridoxal isonicotinoyl hydrazone was investigated using rabbit reticulocytes with the aim of providing more information on the normal process of iron uptake by developing erythroid cells.	Iron	84-88	serotransferrin	Oryctolagus cuniculus	101-112
6882755-1	1983	The mechanism by which bipyridine and phenanthroline types of iron chelator inhibit iron uptake from transferrin and iron efflux mediated by pyridoxal isonicotinoyl hydrazone was investigated using rabbit reticulocytes with the aim of providing more information on the normal process of iron uptake by developing erythroid cells.	Iron	84-88	serotransferrin	Oryctolagus cuniculus	101-112
6882755-2	1983	It was shown that the chelators block cellular uptake by chelating the iron immediately after release from transferrin while it is still in the membrane fraction of the cells.	Iron	71-75	serotransferrin	Oryctolagus cuniculus	107-118
6882755-3	1983	The iron-chelator is then released from the cells by a process which is very similar to that of transferrin release with respect to kinetics and sensitivity to incubation temperature and the effects of metabolic inhibitors and other chemical reagents.	Iron	4-8	serotransferrin	Oryctolagus cuniculus	96-107
6885764-5	1983	During this period, most of the iron originally present in transferrin is donated to the cell.	Iron	32-36	serotransferrin	Oryctolagus cuniculus	59-70
6885764-6	1983	The half-time of 59Fe release from transferrin was 43 s. After the initial 60 s, transferrin, now devoid of iron, is released into the medium.	Iron	108-112	serotransferrin	Oryctolagus cuniculus	81-92
6885764-8	1983	The iron released from transferrin could be transiently found in the cell plasma membrane, the cytosol, and the mitochondria.	Iron	4-8	serotransferrin	Oryctolagus cuniculus	23-34
6885764-10	1983	Finally, the iron was incorporated into heme with a half-time of incorporation of 173 s. We conclude that the release of iron from transferrin is one of the fastest events occurring after the initial binding of transferrin.	Iron	13-17	serotransferrin	Oryctolagus cuniculus	131-142
6885764-10	1983	Finally, the iron was incorporated into heme with a half-time of incorporation of 173 s. We conclude that the release of iron from transferrin is one of the fastest events occurring after the initial binding of transferrin.	Iron	13-17	serotransferrin	Oryctolagus cuniculus	211-222
6885764-10	1983	Finally, the iron was incorporated into heme with a half-time of incorporation of 173 s. We conclude that the release of iron from transferrin is one of the fastest events occurring after the initial binding of transferrin.	Iron	121-125	serotransferrin	Oryctolagus cuniculus	131-142
6885764-10	1983	Finally, the iron was incorporated into heme with a half-time of incorporation of 173 s. We conclude that the release of iron from transferrin is one of the fastest events occurring after the initial binding of transferrin.	Iron	121-125	serotransferrin	Oryctolagus cuniculus	211-222
6885764-11	1983	The limiting step in the entire process of iron delivery is the dissociation of apotransferrin from its receptor, a step which will enable the latter to undergo another cycle of transferrin binding.	Iron	43-47	serotransferrin	Oryctolagus cuniculus	83-94
6135697-0	1983	The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes.	Iron	44-48	serotransferrin	Oryctolagus cuniculus	61-72
6135697-7	1983	Reticulocytes accumulate iron atoms from diferric transferrin at twice the rate at which transferrin molecules are internalized, implying that iron enters the cell while still bound to transferrin.	Iron	25-29	serotransferrin	Oryctolagus cuniculus	50-61
6135697-7	1983	Reticulocytes accumulate iron atoms from diferric transferrin at twice the rate at which transferrin molecules are internalized, implying that iron enters the cell while still bound to transferrin.	Iron	143-147	serotransferrin	Oryctolagus cuniculus	50-61
6135697-7	1983	Reticulocytes accumulate iron atoms from diferric transferrin at twice the rate at which transferrin molecules are internalized, implying that iron enters the cell while still bound to transferrin.	Iron	143-147	serotransferrin	Oryctolagus cuniculus	89-100
6135697-7	1983	Reticulocytes accumulate iron atoms from diferric transferrin at twice the rate at which transferrin molecules are internalized, implying that iron enters the cell while still bound to transferrin.	Iron	143-147	serotransferrin	Oryctolagus cuniculus	89-100
6135697-8	1983	The activation energies for iron accumulation from transferrin are similar to those of endocytosis of transferrin.	Iron	28-32	serotransferrin	Oryctolagus cuniculus	51-62
6135697-8	1983	The activation energies for iron accumulation from transferrin are similar to those of endocytosis of transferrin.	Iron	28-32	serotransferrin	Oryctolagus cuniculus	102-113
6135697-9	1983	This study provides further evidence that transferrin-iron enters the cell by receptor-mediated endocytosis and that iron release occurs within the cell.	Iron	54-58	serotransferrin	Oryctolagus cuniculus	42-53
6658351-0	1983	[Density of iron bioavailable in the usual diet in the State of Sao Paulo].	Iron	12-16	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	64-67
6307387-0	1983	Effect of pH and iron content of transferrin on its binding to reticulocyte receptors.	Iron	17-21	serotransferrin	Oryctolagus cuniculus	33-44
6307387-5	1983	It is proposed that the high affinity of apotransferrin for its receptor at lower pH values and low affinity at pH 7.0 or above allow transferrin to remain bound to the receptor when it is within acidic intracellular vesicles, even after loss of its iron, but also allow ready release from the cell membrane when it is exteriorized by exocytosis after iron uptake.	Iron	250-254	serotransferrin	Oryctolagus cuniculus	44-55
6307387-5	1983	It is proposed that the high affinity of apotransferrin for its receptor at lower pH values and low affinity at pH 7.0 or above allow transferrin to remain bound to the receptor when it is within acidic intracellular vesicles, even after loss of its iron, but also allow ready release from the cell membrane when it is exteriorized by exocytosis after iron uptake.	Iron	352-356	serotransferrin	Oryctolagus cuniculus	44-55
6412692-0	1983	Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase.	Iron	102-106	uroporphyrinogen decarboxylase	Gallus gallus	118-148
6310669-10	1983	It is concluded that iron-containing transferrin molecules enter the trophoblast cells by endocytosis or via a canalicular system after binding to cell membrane receptors.	Iron	21-25	serotransferrin	Oryctolagus cuniculus	37-48
6310669-11	1983	The higher affinity of the receptors for diferric transferrin than for apotransferrin explains the difference in amount of transferrin binding found within 15 min of injecting labelled diferric transferrin and that found 45-75 min later when much of the iron had been removed from the transferrin.	Iron	254-258	serotransferrin	Oryctolagus cuniculus	50-61
6310669-11	1983	The higher affinity of the receptors for diferric transferrin than for apotransferrin explains the difference in amount of transferrin binding found within 15 min of injecting labelled diferric transferrin and that found 45-75 min later when much of the iron had been removed from the transferrin.	Iron	254-258	serotransferrin	Oryctolagus cuniculus	74-85
6310669-11	1983	The higher affinity of the receptors for diferric transferrin than for apotransferrin explains the difference in amount of transferrin binding found within 15 min of injecting labelled diferric transferrin and that found 45-75 min later when much of the iron had been removed from the transferrin.	Iron	254-258	serotransferrin	Oryctolagus cuniculus	74-85
6310669-11	1983	The higher affinity of the receptors for diferric transferrin than for apotransferrin explains the difference in amount of transferrin binding found within 15 min of injecting labelled diferric transferrin and that found 45-75 min later when much of the iron had been removed from the transferrin.	Iron	254-258	serotransferrin	Oryctolagus cuniculus	74-85
6303441-7	1983	While the levels of cytochrome c and myoglobin approximated the iron levels in muscle, they did not change significantly in the heart.	Iron	64-68	myoglobin	Rattus norvegicus	37-46
6443594-6	1983	In contrast to the enzyme from E. coli, B. subtilis amidophosphoribosyltransferase contains an essential Fe-S center.	Iron	105-109	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	52-82
6443594-8	1983	As a consequence of the Fe-S center B. subtilis amidophosphoribosyltransferase is oxygen-sensitive in vitro.	Iron	24-28	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	48-78
6443594-9	1983	Amidophosphoribosyltransferase from mammalian sources is similar to the B. subtilis enzyme in its oxygen-sensitivity which may result from an Fe-S center.	Iron	142-146	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	0-30
6572903-8	1983	Immunoprecipitation studies performed on cells that had been incubated with 59Fe-containing transferrin indicated that chromosome 19-containing cells incorporated iron into intact and functional molecules of human ferritin.	Iron	163-167	ferritin, mitochondrial	Cricetulus griseus	214-222
7126482-0	1982	Studies on the partition of transferrin-donated iron in rabbit reticulocytes.	Iron	48-52	serotransferrin	Oryctolagus cuniculus	28-39
7126482-3	1982	The distribution of transferrin-donated iron between the stroma and cytosol compartments of rabbit reticulocytes was studied.	Iron	40-44	serotransferrin	Oryctolagus cuniculus	20-31
6123998-5	1982	The insertion of iron into protoporphyrin IX to form heme or hematin renders the metalloporphyrin an inhibitor of unactivated or activated guanylate cyclase.	Iron	17-21	guanylate cyclase	Bos taurus	139-156
6279159-0	1982	Chemical, but not functional, differences between the iron-binding sites of rabbit transferrin.	Iron	54-58	serotransferrin	Oryctolagus cuniculus	83-94
33937615-3	2021	The subcellular locations of transferrin receptor and ferroportin 1 in iron-transporting cells in the mouse placenta have not been directly assessed.	Iron	71-75	transferrin receptor	Mus musculus	29-49
33791166-0	2021	Impact of HFE gene variants on iron overload, overall survival and leukemia-free survival in myelodysplastic syndromes.	Iron	31-35	homeostatic iron regulator	Homo sapiens	10-13
33272776-4	2021	PMPCA codes frataxin, which is crucial for iron biosynthesis in cells.	Iron	43-47	peptidase, mitochondrial processing subunit alpha	Homo sapiens	0-5
33272776-4	2021	PMPCA codes frataxin, which is crucial for iron biosynthesis in cells.	Iron	43-47	frataxin	Homo sapiens	12-20
33295111-10	2021	In contrast, the administration of CS-IONPs displayed the highest spleen iron accumulation.	Iron	73-77	citrate synthase	Rattus norvegicus	35-37
6432569-0	1984	The identification of transferrin, an iron-binding protein in rabbit tears.	Iron	38-42	serotransferrin	Oryctolagus cuniculus	22-33
6432569-2	1984	Ouchterlony analysis showed that rabbit tears contain the iron-binding protein transferrin and that tear transferrin has complete antigenic identity with serum and milk transferrin.	Iron	58-62	serotransferrin	Oryctolagus cuniculus	79-90
6327680-9	1984	Cytochrome P-450-dependent ethanol oxidation under in vivo conditions would, according to this concept, require the presence of non-heme iron and endogenous iron chelators.	Iron	137-141	cytochrome P-450	Oryctolagus cuniculus	0-16
6327680-9	1984	Cytochrome P-450-dependent ethanol oxidation under in vivo conditions would, according to this concept, require the presence of non-heme iron and endogenous iron chelators.	Iron	157-161	cytochrome P-450	Oryctolagus cuniculus	0-16
6329212-0	1984	Changes in cytochrome P-450 iron spin state as a function of castration, testosterone or estrogen treatment, vigorous exercise, or starvation.	Iron	28-32	cytochrome P-450	Oryctolagus cuniculus	11-27
6377380-0	1984	[Iron content of the blood and saturation of serum transferrin with iron as affected by roentgen rays].	Iron	68-72	serotransferrin	Oryctolagus cuniculus	51-62
6377380-1	1984	Total-body X-irradiation of rabbits with a dose of 4.5 Gy caused appreciable changes in the iron content of blood and iron saturation of blood serum transferrin over a period from 30 min to 30 days.	Iron	118-122	serotransferrin	Oryctolagus cuniculus	149-160
6743230-0	1984	The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes.	Iron	18-22	serotransferrin	Oryctolagus cuniculus	37-48
6743230-3	1984	At 4 degrees C the average value for the association constant for the binding of transferrin to reticulocytes was found to increase with increasing iron content of the protein.	Iron	148-152	serotransferrin	Oryctolagus cuniculus	81-92
6743230-4	1984	The association constant for apotransferrin binding was 4.6 X 10(6)M-1, for monoferric (C-terminal iron) 2.5 X 10(7)M-1, for monoferric (N-terminal iron) 2.8 X 10(7)M-1 and for diferric transferrin, 1.1 X 10(8)M-1.	Iron	148-152	serotransferrin	Oryctolagus cuniculus	32-43
6324864-0	1984	Reductive activation of phenylalanine hydroxylase and its effect on the redox state of the non-heme iron.	Iron	100-104	phenylalanine hydroxylase	Homo sapiens	24-49
6319396-0	1984	The effect of monoclonal antibodies to the human transferrin receptor on transferrin and iron uptake by rat and rabbit reticulocytes.	Iron	89-93	transferrin receptor	Homo sapiens	49-69
6319396-1	1984	The effect of monoclonal antibodies to the human transferrin receptor on transferrin and iron uptake by rat and rabbit reticulocytes has been examined.	Iron	89-93	transferrin receptor	Homo sapiens	49-69
6643443-8	1983	Further, the nature of the total electronic interactions between both axial ligands and the heme iron of ferrous P-450 and not solely the cysteinate ligand determines whether the ligand complexes will be of the hyper or nonhyperporphyrin category.	Iron	97-101	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	113-118
6579541-5	1983	Of the two highly conserved cysteinyl peptides in P-450LM2, P-450b, and bacterial P-450cam, we favor, on the basis of our model, the one nearer the NH2 terminus (Cys-152 in P-450LM2) as the source of the thiolate ligand to the heme iron atom.	Iron	232-236	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	60-66
6283624-2	1982	This complex was shown to bind and donate its iron to the cells in a manner comparable to native iron-transferrin.	Iron	97-101	serotransferrin	Oryctolagus cuniculus	102-113
7056739-0	1982	Iron transfer between the purple phosphatase uteroferrin and transferrin and its possible role in iron metabolism of the fetal pig.	Iron	0-4	transferrin	Sus scrofa	61-72
6626162-0	1983	Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice.	Iron	13-17	uroporphyrinogen decarboxylase	Mus musculus	57-87
7056739-9	1982	The transfer of iron between uteroferrin and transferrin has also been followed in vitro.	Iron	16-20	transferrin	Sus scrofa	45-56
7056739-12	1982	Results are consistent with a model in which maternal uteroferrin can transfer its iron to fetal transferrin via a low molecular weight intermediary in the allantoic sac.	Iron	83-87	transferrin	Sus scrofa	97-108
7056739-13	1982	Transferrin is then responsible for iron distribution to the fetus.	Iron	36-40	transferrin	Sus scrofa	0-11
6626162-1	1983	The combination of a single subcutaneous dose of iron (12.5 mg/mouse) and subsequent treatment with hexachlorobenzene (0.02% of the diet) caused a progressive inhibition of hepatic uroporphyrinogen decarboxylase in male C57BL/10 mice leading to the accumulation of uroporphyrin in 4-6 weeks.	Iron	49-53	uroporphyrinogen decarboxylase	Mus musculus	181-211
7094429-4	1982	Proteolytic enzymes, chelating agents (EDTA, EGTA), neuraminidase, concanavalin A and primaquine all inhibited iron binding in the cytosol fraction.	Iron	111-115	neuraminidase 1	Homo sapiens	52-65
6679774-2	1983	The addition of cytochrome b5 to cytochrome P-450 results in transition of cytochrome P-450 heme iron from low to high spin state.	Iron	97-101	cytochrome P-450	Oryctolagus cuniculus	33-49
6679774-2	1983	The addition of cytochrome b5 to cytochrome P-450 results in transition of cytochrome P-450 heme iron from low to high spin state.	Iron	97-101	cytochrome P-450	Oryctolagus cuniculus	75-91
6456700-5	1981	In five of the patients with Graves" disease, staining with Mowry"s colloidal iron disclosed dense deposits of mucin in the papillary dermis, with a distribution similar to that reported for pretibial myxedema.	Iron	78-82	LOC100508689	Homo sapiens	111-116
6821651-0	1983	Studies on the partition of transferrin-donated iron in rabbit reticulocytes.	Iron	48-52	serotransferrin	Oryctolagus cuniculus	28-39
6297567-7	1983	The EPR spectrum of isolated ferricytochrome c1 is that of a low-spin heme iron compound with a gz value of 3.36 and a gy value of 2.04.	Iron	75-79	HEME	Bos taurus	70-74
7462336-0	1980	Effect of changes in the ionic environment of reticulocytes on the uptake of transferrin-bound iron.	Iron	34-38	serotransferrin	Oryctolagus cuniculus	77-88
7462336-7	1980	It was concluded that low ionic strength inhibits iron uptake primarily by blocking the endocytosis of transferrin.	Iron	50-54	serotransferrin	Oryctolagus cuniculus	103-114
7462336-10	1980	This action was due to an effect on the release of iron from transferrin, which appeared to be taken up by the cells in a normal manner.	Iron	51-55	serotransferrin	Oryctolagus cuniculus	61-72
7462336-12	1980	However, with CaCl2 concentrations above 10 mM, iron uptake was inhibited, due to inhibition of transferrin uptake, possibly by blocking endocytosis.	Iron	48-52	serotransferrin	Oryctolagus cuniculus	96-107
7462336-14	1980	The results are discussed in terms of the possible effects of ionic strength, pH, and ionic composition of the extracellular fluid on the three main steps involved in iron uptake by immature erythroid cells: transferrin-receptor interaction, endocytosis, and iron release from transferrin.	Iron	167-171	serotransferrin	Oryctolagus cuniculus	277-288
7119114-1	1982	Rabbit transferrin in vitro is shown to load ferrous iron at random on its specific binding sites.	Iron	53-57	serotransferrin	Oryctolagus cuniculus	7-18
7248456-5	1980	This technique has been applied to high resolution x-ray diffraction data from sperm whale myoglobin in its Met iron and oxy cobalt forms.	Iron	112-116	myoglobin	Physeter catodon	91-100
7426867-1	1980	Consideration has been given to the use of iron as an aid in 67Ga scanning.	Iron	43-47	activation induced cytidine deaminase	Homo sapiens	54-57
31050314-12	2021	CONCLUSION: Iron and MPTP co-treatment may result in worsened behavioral and neurochemical deficits and aggravated redox imbalance through inducing microglial p38 MAPK activation.	Iron	12-16	mitogen-activated protein kinase 14	Mus musculus	159-162
33507238-4	2021	The signal of iron deprivation requires Tor2/Ypk1 activity and the inactivation of Tor1 leading to Atg13 dephosphorylation, thus triggering the autophagy process.	Iron	14-18	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	45-49
7119114-4	1982	Diferric transferrin, while giving a similar tissue distribution of radioiron, has a plasma iron clearance rate approximately twice that of the monoferric transferrins at low plasma iron concentrations.	Iron	73-77	serotransferrin	Oryctolagus cuniculus	9-20
33672495-2	2021	The lack of frataxin induces the dysregulation of mitochondrial iron homeostasis and oxidative stress, which finally causes the neuronal death.	Iron	64-68	frataxin	Homo sapiens	12-20
6249208-0	1980	Electron paramagnetic resonance properties and oxidation-reduction potentials of the molybdenum, flavin, and iron-sulfur centers of chicken liver xanthine dehydrogenase.	Iron	109-113	xanthine dehydrogenase	Gallus gallus	146-168
7119114-4	1982	Diferric transferrin, while giving a similar tissue distribution of radioiron, has a plasma iron clearance rate approximately twice that of the monoferric transferrins at low plasma iron concentrations.	Iron	92-96	serotransferrin	Oryctolagus cuniculus	9-20
7119114-8	1982	The molecular behavior of transferrin and its iron over this range was investigated using (125)I-transferrin, [(55)Fe]monoferric transferrin, and [(59)Fe]diferric transferrin.	Iron	46-50	serotransferrin	Oryctolagus cuniculus	26-37
7119114-12	1982	A formula is proposed for correcting the plasma iron turnover, thereby eliminating the effect of plasma iron concentration, so as to reflect directly the number of tissue transferrin receptors.	Iron	48-52	serotransferrin	Oryctolagus cuniculus	171-182
7126527-9	1982	The Mossbauer spectra of reduced hydroxylamine oxidoreductase which had been exposed to CO showed a new spectral component, corresponding to one iron site, with parameters characteristic of a low-spin ferrous heme-carbonyl complex.	Iron	145-149	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	47-61
7378455-5	1980	Trypsin digestion considerably reduced the ability of pig and bovine transferrins to donate iron to rabbit reticulocytes, slightly reduced the iron-donating ability of rabbit transferrin, and had almost no effect on that of human or horse transferrins.	Iron	92-96	serotransferrin	Oryctolagus cuniculus	69-80
33571267-11	2021	Soluble transferrin receptor levels were more saturated among children from the iron group compared to non-iron group (p = 0.012).	Iron	80-84	transferrin receptor	Homo sapiens	8-28
33571267-11	2021	Soluble transferrin receptor levels were more saturated among children from the iron group compared to non-iron group (p = 0.012).	Iron	107-111	transferrin receptor	Homo sapiens	8-28
6800201-0	1982	Effect of iron saturation on transferrin uptake by reticulocytes.	Iron	10-14	serotransferrin	Oryctolagus cuniculus	29-40
33613327-1	2021	Lipocalin-2 (LCN2) is a 25 kDa secreted protein that belongs to the family of lipocalins, a group of transporters of small hydrophobic molecules such as iron, fatty acids, steroids, and lipopolysaccharide in circulation.	Iron	153-157	lipocalin 2	Mus musculus	0-11
33613327-1	2021	Lipocalin-2 (LCN2) is a 25 kDa secreted protein that belongs to the family of lipocalins, a group of transporters of small hydrophobic molecules such as iron, fatty acids, steroids, and lipopolysaccharide in circulation.	Iron	153-157	lipocalin 2	Mus musculus	13-17
33613327-2	2021	LCN2 was previously found to be involved in iron delivery, pointing toward a potential role for LCN2 in immunity.	Iron	44-48	lipocalin 2	Mus musculus	0-4
33613327-3	2021	This idea was further validated when LCN2 was found to limit bacterial growth during infections in mice by sequestering iron-laden siderophores.	Iron	120-124	lipocalin 2	Mus musculus	37-41
33393230-0	2021	The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity.	Iron	34-38	OTU deubiquitinase 1	Homo sapiens	19-24
33393230-6	2021	Mechanistically, OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transportation through deubiquitinating and stabilizing IREB2, leading to increased ROS generation and ferroptosis.	Iron	79-83	OTU deubiquitinase 1	Homo sapiens	17-22
33393230-6	2021	Mechanistically, OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transportation through deubiquitinating and stabilizing IREB2, leading to increased ROS generation and ferroptosis.	Iron	79-83	transferrin receptor	Homo sapiens	32-62
33393230-6	2021	Mechanistically, OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transportation through deubiquitinating and stabilizing IREB2, leading to increased ROS generation and ferroptosis.	Iron	79-83	transferrin receptor	Homo sapiens	64-68
33393230-9	2021	Our data demonstrate that OTUD1 plays a stimulatory role in iron transportation and highlight the importance of OTUD1-IREB2-TFRC signaling axis in host antitumor immunity.	Iron	60-64	OTU deubiquitinase 1	Homo sapiens	26-31
33393230-9	2021	Our data demonstrate that OTUD1 plays a stimulatory role in iron transportation and highlight the importance of OTUD1-IREB2-TFRC signaling axis in host antitumor immunity.	Iron	60-64	transferrin receptor	Homo sapiens	124-128
33017703-5	2021	Indeed, we then identified that ferroptosis is a novel PCD driven by TCBQ, which was correlated with a decrease in glutathione peroxidase 4 (GPX4) level and iron accumulation by altering iron metabolism.	Iron	187-191	glutathione peroxidase 4	Rattus norvegicus	141-145
33297854-5	2021	Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the DEGs were mainly enriched in synaptic signaling or transmission, and hormone secretion pathways, in which insulin secretion, and oxytocin signaling pathways were closely associated with FE by regulating feeding behavior and energy metabolism (adjusted p-values <0.05).	Iron	287-289	insulin	Sus scrofa	207-214
33297854-6	2021	Further, the transcription factors (TFs) analysis and gene co-expression network analysis indicated three hub differentially expressed TFs (NR2F2, TFAP2D, and HNF1B) that affected FE by mainly regulating feeding behavior, insulin sensitivity, or energy metabolism.	Iron	180-182	transcription factor AP-2 delta	Sus scrofa	147-153
33297854-6	2021	Further, the transcription factors (TFs) analysis and gene co-expression network analysis indicated three hub differentially expressed TFs (NR2F2, TFAP2D, and HNF1B) that affected FE by mainly regulating feeding behavior, insulin sensitivity, or energy metabolism.	Iron	180-182	insulin	Sus scrofa	222-229
7363562-3	1980	There was a small but insignificant decrease in the activity of glutathione reductase in patients with secondary iron overload due to multiple transfusion therapy for thalassaemia major.	Iron	113-117	glutathione-disulfide reductase	Homo sapiens	64-85
515872-0	1979	Activation of uroporphyrinogen decarboxylase by ferrous iron in porphyria cutanea tarda.	Iron	48-60	uroporphyrinogen decarboxylase	Homo sapiens	14-44
515872-1	1979	Uroporphyrinogen decarboxylase was measured in the presence of ferrous iron, using mitochondria-free rat liver extracts as enzyme source.	Iron	63-75	uroporphyrinogen decarboxylase	Rattus norvegicus	0-30
515872-3	1979	Enzyme kinetics indicate that uroporphyrinogen decarboxylase reversibly binds ferrous iron, with a binding constant of approximately 5 x 10(4) mol-1.	Iron	78-90	uroporphyrinogen decarboxylase	Homo sapiens	30-60
515872-4	1979	It is proposed that the effect of phlebotomy on patients with porphyria cutanea tarda is to mobilze storage iron in the liver to the active ferrous form, which activates hepatic uroporphyrinogen decarboxylase, the enzyme which is defective in this syndrome, with resultant clinical and biochemical remission.	Iron	108-112	uroporphyrinogen decarboxylase	Homo sapiens	178-208
224062-24	1979	15, 338-344) and thus demonstrate that this iron-sulfur protein is required for electron transfer from ubiquinol to cytochrome c in the mitochondrial respiratory chain.	Iron	44-48	LOC104968582	Bos taurus	116-128
468828-2	1979	Laser excitation within the visible absorption band of uteroferrin results in an intense resonance Raman spectrum which bears a striking resemblance to that reported for Fe(III)-transferrin, the iron transport protein of serum.	Iron	195-199	transferrin	Sus scrofa	178-189
497270-5	1979	The non-haem iron of pea ferredoxin interacts with the complex formers far more rapidly as compared to corn ferredoxin.	Iron	13-17	ferredoxin	Zea mays	25-35
497270-5	1979	The non-haem iron of pea ferredoxin interacts with the complex formers far more rapidly as compared to corn ferredoxin.	Iron	13-17	ferredoxin	Zea mays	108-118
225188-4	1979	Particles such as zymosan, inulin, latex, and iron filings stimulated CSA release from mouse peritoneal cells but not from thymic epthelial cells.	Iron	46-50	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	70-73
221049-4	1979	As the reticulocytes matured there was a parallel decline in their ability to take up transferrin and transferrin iron.	Iron	114-118	serotransferrin	Oryctolagus cuniculus	102-113
23866-1	1978	Rabbit reticulocyte incorporation of iron from rabbit transferrin was independent of transferrin iron saturation but uptake from human transferrin was saturation dependent.	Iron	37-41	serotransferrin	Oryctolagus cuniculus	54-65
23866-2	1978	Unlike human transferrin, rabbit transferrin does not surrender its iron from any unique preferred iron-binding site and can be described as functionally homogeneic.	Iron	99-103	serotransferrin	Oryctolagus cuniculus	33-44
409685-6	1977	When the cured strain was lysogenized with phage carrying a mutation in the tox structural gene, the lysogen produced the mutant protein at the maximum rate in medium with excess iron.	Iron	179-183	thymocyte selection associated high mobility group box	Homo sapiens	76-79
911316-5	1977	In both experiments, iron uptake by reticulocytes corresponded to utilization of a ferric ion from diferric transferrin before utilization of iron from monoferric transferrin.	Iron	21-25	serotransferrin	Oryctolagus cuniculus	108-119
913393-1	1977	Structural rearrangements in sperm whale myoglobin and leghaemoglobins caused by changes in the spin or oxidation state of the iron as a consequence of ligand binding have been measured by difference spectroscopy in the ultraviolet.	Iron	127-131	myoglobin	Physeter catodon	41-50
864688-3	1977	There was a close correlation between the iron uptake rate and the rate and amount of transferrin uptake and the amount of the lysophospholipids in the membrane.	Iron	42-46	serotransferrin	Oryctolagus cuniculus	86-97
864688-7	1977	The present investigation provides evidence that the phospholipid composition of the cell membrane influences the interaction of transferrin with its receptors, the processes of endocytosis and exocytosis whereby transferrin enters and leaves the cells, and the mechanism by which iron is mobilized between its binding to transferrin and incorporation into heme.	Iron	281-285	serotransferrin	Oryctolagus cuniculus	213-224
864688-7	1977	The present investigation provides evidence that the phospholipid composition of the cell membrane influences the interaction of transferrin with its receptors, the processes of endocytosis and exocytosis whereby transferrin enters and leaves the cells, and the mechanism by which iron is mobilized between its binding to transferrin and incorporation into heme.	Iron	281-285	serotransferrin	Oryctolagus cuniculus	213-224
265135-6	1977	Iron and folate deficiency each suppressed Hb A2 levels in beta-thalassemia heterozygotes; however, vitamin B12 deficiency did not alter the percentage of Hb A2 in thalassemia.	Iron	0-4	hemoglobin subunit alpha 2	Homo sapiens	43-48
831800-2	1977	The mechanism by which the utilization of transferrin-bound iron is linked with cellular metabolism was investigated using rabbit reticulocytes and bone marrow cells.	Iron	60-64	serotransferrin	Oryctolagus cuniculus	42-53
999893-10	1976	For ovotransferrin and sheep transferrin it is necessary to postulate interaction between the iron-binding sites to account for the change in Stokes" radius caused by the second iron atom binding being greater than for the first.	Iron	94-98	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	7-18
999893-10	1976	For ovotransferrin and sheep transferrin it is necessary to postulate interaction between the iron-binding sites to account for the change in Stokes" radius caused by the second iron atom binding being greater than for the first.	Iron	178-182	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	7-18
975400-1	1976	It has been suggested that the binding of iron(III) by phosvitin involves the phosphoric radicals of phosphorylserine residues, many of which are arranged in rows of several consecutive phosphoamino acids.	Iron	42-46	casein kinase 2 beta	Homo sapiens	55-64
975400-4	1976	These findings indicate that polyphosphorylserine blocks play an important role in the binding of iron by phosvitin, and that in the intact protein their binding capacity is optimized by the conformation of the polypeptide chain.	Iron	98-102	casein kinase 2 beta	Homo sapiens	106-115
2617-5	1976	A ferrous iron-transferrin mixture, however, protects only against alpha,alpha-dipyridyl.	Iron	10-14	serotransferrin	Oryctolagus cuniculus	15-26
6800201-2	1982	The presence of iron on the transferrin molecule increases its affinity for and sojourn time on the reticulocyte.	Iron	16-20	serotransferrin	Oryctolagus cuniculus	28-39
2617-16	1976	In iron deficiency or chronic disease (where iron is not available to the erythroblast for heme synthesis) HCR appears prematurely and inhibits protein synthesis.	Iron	3-7	eukaryotic translation initiation factor 2-alpha kinase 1	Oryctolagus cuniculus	107-110
6800201-3	1982	This could be due to selective internalization of iron-containing transferrin molecules.	Iron	50-54	serotransferrin	Oryctolagus cuniculus	66-77
2617-17	1976	When heme synthesis is inhibited by ethanol but there is sufficient intracellular iron, HCR appears prematurely and inhibits protein synthesis, iron accumulates in the erythroblast, and the end result is sideroblastic anemia.	Iron	82-86	eukaryotic translation initiation factor 2-alpha kinase 1	Oryctolagus cuniculus	88-91
6800201-6	1982	The results showed that (1) both apotransferrin and iron transferrin enter the cell interior and (2) the amount of intracellular transferrin was primarily controlled by the concentration of membrane-bound transferrin and not by its iron saturation.	Iron	52-56	serotransferrin	Oryctolagus cuniculus	57-68
6800201-6	1982	The results showed that (1) both apotransferrin and iron transferrin enter the cell interior and (2) the amount of intracellular transferrin was primarily controlled by the concentration of membrane-bound transferrin and not by its iron saturation.	Iron	52-56	serotransferrin	Oryctolagus cuniculus	57-68
6177316-12	1982	An iron-binding protein with an apparent Mr of 80 000 was shown to be immunologically and structurally identical with serum transferrin.	Iron	3-7	serotransferrin	Oryctolagus cuniculus	124-135
1015157-1	1976	The heme related circular dichroic bands of solubilized cytochrome P-450 from rabbit liver and some of its complexes with type I- and type II-substrayes and heme iron ligands were measured in the Soret region.	Iron	162-166	cytochrome P-450	Oryctolagus cuniculus	56-72
1174530-1	1975	The transfer of iron from transferrin to the developing erythrocyte is a research area of high interest and considerable controversy.	Iron	16-20	serotransferrin	Oryctolagus cuniculus	26-37
7037039-4	1982	In one case, the ultrastructural distribution of mucin was demonstrated using colloidal iron staining, electron microscopy and X-ray microanalysis.	Iron	88-92	LOC100508689	Homo sapiens	49-54
1174530-6	1975	The iodotransferrin products exhibit the same iron donation ability, however, evidence was found that the chloramine-T treatment leads to a nonspecific binding of transferrin to the reticulocyte.	Iron	46-50	serotransferrin	Oryctolagus cuniculus	8-19
1174530-8	1975	Fe(NH4)2(SO4)2 and especially FeCl3 were found to yield nonspecifically bound iron when added to transferrin or serum.	Iron	78-82	serotransferrin	Oryctolagus cuniculus	97-108
7055537-2	1982	When 59Fe-labelled diferric transferrin is injected into normal, anaemic or hypertransfused, polycythaemic rabbits, iron is removed from diferric transferrin in essentially pairwise fashion.	Iron	116-120	serotransferrin	Oryctolagus cuniculus	28-39
1201218-1	1975	Ethanol, in concentrations of 0.05-0.8 M, inhibited intact human and rabbit reticulocyte protein synthesis in the presence of iron-transferrin for endogenous haem synthesis.	Iron	126-130	serotransferrin	Oryctolagus cuniculus	131-142
7055537-4	1982	The return of iron from tissue stores to circulating transferrin occurs one atom at a time to either site of the protein and, possibly, in pairwise fashion as well.	Iron	14-18	serotransferrin	Oryctolagus cuniculus	53-64
7055537-5	1982	The rate of clearance of iron from diferric transferrin differs from that of monoferric transferrins, and the rates at which iron is returned to empty sites of transferrin also differ, so that serum iron is not a kinetically homogeneous pool in the rabbit.	Iron	25-29	serotransferrin	Oryctolagus cuniculus	44-55
6214811-2	1982	Their increase in the former condition can be attributed to the general stress reaction, but the increase in ceruloplasmin levels in concentration may have a stimulant effect on the ceruloplasmin, when the oxidation of Fe2+ to Fe3+ is potentiated, may obstruct the binding of iron to protoporphyrin and prevent formation of the haeme of cytochrome P 450 and b5.	Iron	276-280	ceruloplasmin	Cavia porcellus	109-122
1127500-2	1975	Since MAO is an important enzyme in inactivation of catecholamines, urinary excretion of DA, NE, E, MN-NMN, and VMA was measured in 24-hour samples from 11 iron-deficient children before and after treatment with intramuscular iron.	Iron	156-160	monoamine oxidase A	Rattus norvegicus	6-9
1127500-2	1975	Since MAO is an important enzyme in inactivation of catecholamines, urinary excretion of DA, NE, E, MN-NMN, and VMA was measured in 24-hour samples from 11 iron-deficient children before and after treatment with intramuscular iron.	Iron	226-230	monoamine oxidase A	Rattus norvegicus	6-9
1127500-7	1975	These findings suggest that the irritability, lack of attentiveness, and low performance scores of iron-deficient children may be related to alterations in catecholamine metabolic pathways secondary to dependence of MAO on adequate iron stores.	Iron	99-103	monoamine oxidase A	Rattus norvegicus	216-219
6214811-2	1982	Their increase in the former condition can be attributed to the general stress reaction, but the increase in ceruloplasmin levels in concentration may have a stimulant effect on the ceruloplasmin, when the oxidation of Fe2+ to Fe3+ is potentiated, may obstruct the binding of iron to protoporphyrin and prevent formation of the haeme of cytochrome P 450 and b5.	Iron	276-280	ceruloplasmin	Cavia porcellus	182-195
1127500-7	1975	These findings suggest that the irritability, lack of attentiveness, and low performance scores of iron-deficient children may be related to alterations in catecholamine metabolic pathways secondary to dependence of MAO on adequate iron stores.	Iron	232-236	monoamine oxidase A	Rattus norvegicus	216-219
33336851-14	2021	Iron accumulation led to the high expression of XIST and promoted osteoblast apoptosis through miR-758-3p/caspase 3.	Iron	0-4	microRNA 758	Mus musculus	95-102
7295776-5	1981	This frequency and those of other structure-sensitive bands implied that the heme iron of oxidized P-450SCC adopts the hexa-coordinate high-spin structure, in contrast with the high-spin type cytochrome P-450 purified from phenobarbital- or 3-methylcholanthrene-treated rabbit liver microsomes which presumably have a penta-coordinate structure.	Iron	82-86	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	99-107
33336851-16	2021	CONCLUSION: Iron accumulation regulated osteoblast apoptosis through XIST/miR-758-3p/caspase 3 axis, which might provide alternative targets for the treatment of osteoporosis.	Iron	12-16	microRNA 758	Mus musculus	74-81
1120101-4	1975	In contrast, diferric and monoferric rabbit transferrin both donated iron to reticulocytes at the same rate, per iron atom.	Iron	69-73	serotransferrin	Oryctolagus cuniculus	44-55
1120101-4	1975	In contrast, diferric and monoferric rabbit transferrin both donated iron to reticulocytes at the same rate, per iron atom.	Iron	113-117	serotransferrin	Oryctolagus cuniculus	44-55
7225374-2	1981	The experiments were performed with rabbit reticulocytes and iron bound to rabbit transferrin.	Iron	61-65	serotransferrin	Oryctolagus cuniculus	82-93
4370594-0	1974	Role of 3-mercaptopyruvate sulfurtransferase in the formation of the iron-sulfur chromophore of adrenal ferredoxin.	Iron	69-73	mercaptopyruvate sulfurtransferase	Homo sapiens	8-44
33356182-0	2021	High-Frequency Fe-H and Fe-H2 Modes in a trans-Fe(eta2-H2)(H) Complex: A Speed Record for Nuclear Resonance Vibrational Spectroscopy.	Iron	15-17	DNA polymerase iota	Homo sapiens	50-54
7225374-15	1981	The results are considered to support the hypothesis that iron release from transferrin in reticulocytes occurs as a result of protonation of the transferrin within intracellular vesicles.	Iron	58-62	serotransferrin	Oryctolagus cuniculus	76-87
33157103-3	2021	It has been shown that the yeast mitochondrial transporter Atm1 can export glutathione-coordinated iron-sulfur clusters, [2Fe-2S](SG)4, providing a source of cluster units for cytosolic iron-sulfur cluster assembly systems.	Iron	99-103	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	59-63
33157103-3	2021	It has been shown that the yeast mitochondrial transporter Atm1 can export glutathione-coordinated iron-sulfur clusters, [2Fe-2S](SG)4, providing a source of cluster units for cytosolic iron-sulfur cluster assembly systems.	Iron	186-190	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	59-63
7225374-15	1981	The results are considered to support the hypothesis that iron release from transferrin in reticulocytes occurs as a result of protonation of the transferrin within intracellular vesicles.	Iron	58-62	serotransferrin	Oryctolagus cuniculus	146-157
4854919-10	1974	Iron-chelating and copper-chelating agents inhibited human phenylalanine hydroxylase.	Iron	0-4	phenylalanine hydroxylase	Homo sapiens	59-84
7011976-0	1980	ColV plasmid-mediated, colicin V-independent iron uptake system of invasive strains of Escherichia coli.	Iron	45-49	Colicin V	Escherichia coli	23-32
4357566-0	1973	Mossbauer spectroscopy of iron in human and rabbit transferrin.	Iron	26-30	serotransferrin	Oryctolagus cuniculus	51-62
33253743-5	2021	Our results favor the electrostatic attraction contributes the main reason to the inhibitory effect between the anionic porphyrins and hIAPP, followed by the pi-pi stacking interactions between aromatic ring of porphyrins and hIAPP and the stronger coordination ability of iron center to hIAPP.	Iron	273-277	islet amyloid polypeptide	Homo sapiens	135-140
33253743-5	2021	Our results favor the electrostatic attraction contributes the main reason to the inhibitory effect between the anionic porphyrins and hIAPP, followed by the pi-pi stacking interactions between aromatic ring of porphyrins and hIAPP and the stronger coordination ability of iron center to hIAPP.	Iron	273-277	islet amyloid polypeptide	Homo sapiens	226-231
33253743-5	2021	Our results favor the electrostatic attraction contributes the main reason to the inhibitory effect between the anionic porphyrins and hIAPP, followed by the pi-pi stacking interactions between aromatic ring of porphyrins and hIAPP and the stronger coordination ability of iron center to hIAPP.	Iron	273-277	islet amyloid polypeptide	Homo sapiens	226-231
5000975-0	1971	A study of iron transfer from rabbit transferrin to reticulocytes using synthetic chelating agents.	Iron	11-15	serotransferrin	Oryctolagus cuniculus	37-48
7011976-6	1980	Conversely, mutants isolated as defective in colicin V synthesis were normal for the plasmid-coded iron uptake mechanism and showed the same lethality for infected mice as did strain LG1315.	Iron	99-103	Colicin V	Escherichia coli	45-54
5480864-8	1970	Rat ceruloplasmin, which has little ferroxidase activity, was much less effective than porcine or human ceruloplasmin in inducing increases in plasma iron.	Iron	150-154	ceruloplasmin	Rattus norvegicus	4-17
33254834-8	2021	This significantly affected the flow-on effect of Fe on the phosphate removal during wastewater treatment, removing only 1.2 +- 0.1 mgP L-1, as compared to 3.5 +- 0.1 mgP L-1 achieved previously in the absence of a primary settler.	Iron	50-52	matrix Gla protein	Homo sapiens	132-135
33254834-8	2021	This significantly affected the flow-on effect of Fe on the phosphate removal during wastewater treatment, removing only 1.2 +- 0.1 mgP L-1, as compared to 3.5 +- 0.1 mgP L-1 achieved previously in the absence of a primary settler.	Iron	50-52	matrix Gla protein	Homo sapiens	167-170
6243376-0	1980	Common pathway for tumor cell uptake of gallium-67 and iron-59 via a transferrin receptor.	Iron	55-59	transferrin receptor	Mus musculus	69-89
33254834-9	2021	However, the P to Fe removal ratio was 0.32 mgP/mgFe, similar to the ratio observed previously without primary sedimentation (0.36 mgP/mgFe).	Iron	18-20	matrix Gla protein	Homo sapiens	44-47
5699770-0	1968	Role of transferrin in the placental transfer of iron in the rabbit.	Iron	49-53	serotransferrin	Oryctolagus cuniculus	8-19
33445746-2	2021	Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation.	Iron	25-29	lipocalin 2	Mus musculus	0-11
227849-0	1979	Isolation of the domain containing the molybdenum, iron-sulfur I, and iron-sulfur II centers of chicken liver xanthine dehydrogenase.	Iron	51-55	xanthine dehydrogenase	Gallus gallus	110-132
33445746-2	2021	Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation.	Iron	25-29	lipocalin 2	Mus musculus	13-17
33445746-8	2021	Furthermore, LCN2 deficiency also attenuated KA-induced iron overload and oxidative stress in the hippocampus.	Iron	56-60	lipocalin 2	Mus musculus	13-17
33445746-9	2021	These findings indicate that LCN2 may play an important role in iron-related oxidative stress and neuroinflammation in KA-induced hippocampal cell death.	Iron	64-68	lipocalin 2	Mus musculus	29-33
18960329-1	1968	The reaction between iron(III) and Methylthymol Blue (MTB or H(6)A) has been investigated by spectrophotometry.	Iron	21-25	metallothionein 1J, pseudogene	Homo sapiens	54-67
18960329-2	1968	It has been established that iron(III) and MTB form two complexes with compositions iron(III): MTB = 1:1 and 1:2.	Iron	29-33	metallothionein 1J, pseudogene	Homo sapiens	95-98
18960329-2	1968	It has been established that iron(III) and MTB form two complexes with compositions iron(III): MTB = 1:1 and 1:2.	Iron	84-88	metallothionein 1J, pseudogene	Homo sapiens	43-46
18960329-2	1968	It has been established that iron(III) and MTB form two complexes with compositions iron(III): MTB = 1:1 and 1:2.	Iron	84-88	metallothionein 1J, pseudogene	Homo sapiens	95-98
42443-1	1979	Iron release from human, rabbit, rat and sheep transferrin, chicken conalbumin and human lactoferrin was measured by the change in absorbance of solutions of the iron-protein complexes or by the release of 59Fe from the protein conjugated to agarose.	Iron	0-4	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	47-58
25622421-4	1966	As incubation of tissue sections in neuraminidase abolished stainability of the acidic carbohydrate with colloidal iron, the material removed was considered to be a sialomucin.	Iron	115-119	neuraminidase 1	Homo sapiens	36-49
33837742-8	2021	In neural retina of the mutant mice, reduced Tfrc mRNA was also an indicator of retinal iron overload.	Iron	88-92	transferrin receptor	Mus musculus	45-49
33419006-6	2021	Likewise,  NO selectively converts cytosolic aconitase (c-aconitase) into the iron regulatory protein 1 (IRP1), which regulates cellular iron homeostasis through its binding to iron response elements (IRE) located in the mRNAs of iron-related proteins.	Iron	78-82	aconitase 1	Homo sapiens	105-109
33419006-6	2021	Likewise,  NO selectively converts cytosolic aconitase (c-aconitase) into the iron regulatory protein 1 (IRP1), which regulates cellular iron homeostasis through its binding to iron response elements (IRE) located in the mRNAs of iron-related proteins.	Iron	137-141	aconitase 1	Homo sapiens	78-103
471065-1	1979	Plasma transferrin is involved in iron transport within the circulatory system of vertebrates, and provides an iron source for haemoglobin synthesis and other metabolic requirements.	Iron	34-38	serotransferrin	Oryctolagus cuniculus	7-18
33419006-6	2021	Likewise,  NO selectively converts cytosolic aconitase (c-aconitase) into the iron regulatory protein 1 (IRP1), which regulates cellular iron homeostasis through its binding to iron response elements (IRE) located in the mRNAs of iron-related proteins.	Iron	137-141	aconitase 1	Homo sapiens	105-109
33419006-6	2021	Likewise,  NO selectively converts cytosolic aconitase (c-aconitase) into the iron regulatory protein 1 (IRP1), which regulates cellular iron homeostasis through its binding to iron response elements (IRE) located in the mRNAs of iron-related proteins.	Iron	137-141	aconitase 1	Homo sapiens	78-103
33419006-6	2021	Likewise,  NO selectively converts cytosolic aconitase (c-aconitase) into the iron regulatory protein 1 (IRP1), which regulates cellular iron homeostasis through its binding to iron response elements (IRE) located in the mRNAs of iron-related proteins.	Iron	137-141	aconitase 1	Homo sapiens	105-109
33419006-7	2021	Nitric oxide-activated IRP1 can impair cellular iron homeostasis during neuroinflammation, triggering iron accumulation, especially in the mitochondria, leading to neuronal death.	Iron	48-52	aconitase 1	Homo sapiens	23-27
33419006-7	2021	Nitric oxide-activated IRP1 can impair cellular iron homeostasis during neuroinflammation, triggering iron accumulation, especially in the mitochondria, leading to neuronal death.	Iron	102-106	aconitase 1	Homo sapiens	23-27
14271506-0	1965	DISTRIBUTION OF CYTOCHROME C AND MYOGLOBIN IN RATS WITH DIETARY IRON DEFICIENCY.	Iron	64-68	myoglobin	Rattus norvegicus	33-42
14129488-3	1964	The value of serum iron as a diagnostic aid is limited by the wide range in normal subjects and the large variation that occurs in the same individual from hour to hour and day to day.	Iron	19-23	activation induced cytidine deaminase	Homo sapiens	40-43
13980103-0	1963	Interaction between phosvitin and iron and its effect on a rearrangement of phosvitin structure.	Iron	34-38	casein kinase 2 beta	Homo sapiens	20-29
13980103-0	1963	Interaction between phosvitin and iron and its effect on a rearrangement of phosvitin structure.	Iron	34-38	casein kinase 2 beta	Homo sapiens	76-85
33002417-5	2021	LINC00618 also accelerates ferroptosis by increasing the levels of lipid reactive oxygen species (ROS) and iron, two surrogate markers of ferroptosis, and decreasing the expression of solute carrier family 7 member 11 (SLC7A11).	Iron	107-111	long intergenic non-protein coding RNA 618	Homo sapiens	0-9
471065-1	1979	Plasma transferrin is involved in iron transport within the circulatory system of vertebrates, and provides an iron source for haemoglobin synthesis and other metabolic requirements.	Iron	111-115	serotransferrin	Oryctolagus cuniculus	7-18
33402423-8	2021	In neural retina of the mutant mice, reduced Tfrc mRNA was also an indicator of retinal iron overload.	Iron	88-92	transferrin receptor	Mus musculus	45-49
911316-0	1977	Preferential utilization in vitro of iron bound to diferric transferrin by rabbit reticulocytes.	Iron	37-41	serotransferrin	Oryctolagus cuniculus	60-71
14007800-3	1962	A reduction of glucose-6-phosphatase, consistently found in iron-loaded animals, demonstrates the sensitivity of the microsomes to the presence of storage iron.	Iron	60-64	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	15-36
205111-0	1977	Iron and copper metabolism in cancer, as exemplified by changes in ferritin and ceruloplasmin in rats with transplantable tumors.	Iron	0-4	ceruloplasmin	Rattus norvegicus	80-93
14007800-3	1962	A reduction of glucose-6-phosphatase, consistently found in iron-loaded animals, demonstrates the sensitivity of the microsomes to the presence of storage iron.	Iron	155-159	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	15-36
13610905-0	1959	At 5"-nucleotidase activated by ferrous iron.	Iron	32-44	5'-nucleotidase ecto	Homo sapiens	3-18
32215811-0	2021	Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1alpha/MAPK Pathway in the Liver.	Iron	18-22	ghrelin	Mus musculus	81-88
32215811-2	2021	Although previous studies implied a negative relationship between iron and ghrelin in both mice and humans, it remains to be explored whether fasting or ghrelin has a functional effect on iron homeostasis in the liver.	Iron	188-192	ghrelin	Mus musculus	153-160
32215811-8	2021	Our findings confirmed that fasting increases iron export in the liver by upregulating Fpn1 expression through the ghrelin/GHSR1alpha/MAPK signaling pathway.	Iron	46-50	ghrelin	Mus musculus	115-122
831800-6	1977	The rate of transferrin uptake was inhibited to a lesser degree than that of iron uptake, and only when the ATP concentration had fallen below that necessary to inhibit iron uptake.	Iron	169-173	serotransferrin	Oryctolagus cuniculus	12-23
32748118-7	2021	One of possible pathophysiological pathways is iron metabolism, especially HFE gene-regulated iron metabolism pathway.	Iron	47-51	homeostatic iron regulator	Homo sapiens	75-78
32748118-7	2021	One of possible pathophysiological pathways is iron metabolism, especially HFE gene-regulated iron metabolism pathway.	Iron	94-98	homeostatic iron regulator	Homo sapiens	75-78
13500306-0	1958	The effect of the administration of HN2 on the utilization of plasma iron.	Iron	69-73	MT-RNR2 like 2 (pseudogene)	Homo sapiens	36-39
831800-7	1977	It is concluded that the rate of uptake of transferrin-bound iron by immature erythroid cells is dependent on the intracellular concentration of ATP but is independent of the NADH concentration.	Iron	61-65	serotransferrin	Oryctolagus cuniculus	43-54
7308-2	1976	A non-heme iron protein, rubredoxin has been isolated from the sulfate-reducing bacterium, Desulfovibrio vulgaris, strain Hildenborough.	Iron	11-15	DVU3184	Desulfovibrio vulgaris str. Hildenborough	25-35
34034544-9	2022	Likewise, decreased expression of Tfrc and Slc40a1, both of which are crucial proteins for iron transportation, was observed in Lif-/- mice and Lif-knockdown ameloblast lineage cell lines, according to quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot.	Iron	91-95	transferrin receptor	Mus musculus	34-38
33657866-5	2021	Here we find human EP and hepatic progenitor (HP) cells can be produced from human embryonic stem cells with high efficiency, and they also readily uptake iron nanoparticles.	Iron	155-159	epiregulin	Homo sapiens	19-21
34039609-3	2021	Iron-responsive element-binding proteins IRP1 and IRP2 posttranscriptionally regulate iron homeostasis.	Iron	0-4	aconitase 1	Homo sapiens	41-45
1248205-6	1976	Lysosomes from the livers of patients with iron overload were strikingly more fragile than those of control subjects as demonstrated by assays of latent and sedimentable N-acetyl-beta-glucosaminidase.	Iron	43-47	O-GlcNAcase	Homo sapiens	170-199
34039609-3	2021	Iron-responsive element-binding proteins IRP1 and IRP2 posttranscriptionally regulate iron homeostasis.	Iron	86-90	aconitase 1	Homo sapiens	41-45
34039609-8	2021	Deletion of both IRP1 and IRP2 abolishes the iron-starvation response, preventing its activation by ISC synthesis inhibition.	Iron	45-49	aconitase 1	Homo sapiens	17-21
33932034-4	2021	Mechanistically, we found that BNIP3-deprived melanoma cells displayed increased intracellular iron levels caused by heightened NCOA4-mediated ferritinophagy, which fostered PHD2-mediated HIF-1alpha destabilization.	Iron	95-99	BCL2/adenovirus E1B interacting protein 3	Mus musculus	31-36
33065090-0	2021	TIM2 modulates retinal iron levels and is involved in blood-retinal barrier breakdown.	Iron	23-27	T cell immunoglobulin and mucin domain containing 2	Mus musculus	0-4
33065090-3	2021	In this study, the presence and iron-related functions of TIM2 in the mouse retina were investigated.	Iron	32-36	T cell immunoglobulin and mucin domain containing 2	Mus musculus	58-62
33065090-5	2021	Experimental TIM2 downregulation in the mouse retina promoted, probably due to a compensatory mechanism, Scara5 overexpression that increased retinal ferritin uptake and induced iron overload.	Iron	178-182	T cell immunoglobulin and mucin domain containing 2	Mus musculus	13-17
169890-6	1975	Evidence that water forms an innersphere complex with the iron atom of the catalase heme is presented.	Iron	58-62	catalase	Equus caballus	75-83
33390840-7	2021	Moreover, our results showed that iron overload upregulated the expression of P53, which subsequently repressed the protein level of Slc7a11 (solute carrier family 7, member 11), a known ferroptosis-related gene.	Iron	34-38	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	133-140
33390840-7	2021	Moreover, our results showed that iron overload upregulated the expression of P53, which subsequently repressed the protein level of Slc7a11 (solute carrier family 7, member 11), a known ferroptosis-related gene.	Iron	34-38	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	142-176
33390840-9	2021	The findings in this study indicate that iron plays a key role in triggering P53- Slc7a11-mediated ferroptosis in muscles, and suggest that targeting iron accumulation and ferroptosis might be a therapeutic strategy for treating sarcopenia.	Iron	41-45	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	82-89
34022567-11	2021	Several genes of iron metabolism presented a higher expression in DIOS vs MetS: SCL11A2 (a free iron transporter, +76 %, p = 0.04), SOD1 (an antioxidant enzyme, +27 %, p = 0.02), and TFRC (the receptor 1 of transferrin, +59 %, p = 0.003).	Iron	17-21	transferrin receptor	Homo sapiens	183-187
34022567-13	2021	The up regulation of transferrin receptor 1 (TFRC) in DIOS macrophages suggests an adaptive role that may limit iron toxicity in DIOS.	Iron	112-116	transferrin receptor	Homo sapiens	21-43
34022567-13	2021	The up regulation of transferrin receptor 1 (TFRC) in DIOS macrophages suggests an adaptive role that may limit iron toxicity in DIOS.	Iron	112-116	transferrin receptor	Homo sapiens	45-49
33693820-11	2021	Proteins translated from iron-responsive element (IRE)-containing mRNA were altered in abundance; ferritin and ferroportin 1 decreased, while TFRC increased in ID placentas.	Iron	25-29	transferrin receptor	Mus musculus	142-146
33515478-7	2021	On the other hand, supplementation with different Fe levels in the diet significantly increased serum iron and transferrin saturation concentrations (P < 0.05), goblet cell numbers of duodenal villous (P < 0.001), and MUC4 mRNA expression (P < 0.05).	Iron	50-52	transferrin	Sus scrofa	111-122
172099-5	1975	Both 6-phosphogluconate dehydrogenase and glucose 6-phosphate dehydrogenase were reduced in young iron deficient rats but the former had returned to control levels at the age of 14 weeks.	Iron	98-102	glucose-6-phosphate dehydrogenase	Rattus norvegicus	42-75
32901916-0	2021	Arabidopsis thaliana transcription factors MYB28 AND MYB29 shape ammonium stress responses by regulating fe homeostasis.	Iron	105-107	myb domain protein 28	Arabidopsis thaliana	43-48
32901916-8	2021	Interestingly, we overall show that growing Arabidopsis with increased Fe availability relieved ammonium stress symptoms and that this was associated with MYB28 and MYB29 expression.	Iron	71-73	myb domain protein 28	Arabidopsis thaliana	155-160
33955709-10	2021	From in vivo and ex vivo experiments, Tfr1 deletion in SCs results in an irreversible depletion of SCs (~60% reduction, P < 0.005) and cell-autonomous defect in SC proliferation and differentiation, leading to skeletal muscle regeneration impairment, followed by labile iron accumulation, lipogenesis, and decreased Gpx4 and Nrf2 protein levels leading to reactive oxygen species scavenger defects.	Iron	270-274	transferrin receptor	Mus musculus	38-42
33955709-14	2021	However, intramuscular administration of lentivirus-expressing Tfr1 could partially reduce labile iron accumulation, decrease lipogenesis, and promote skeletal muscle regeneration.	Iron	98-102	transferrin receptor	Mus musculus	63-67
33955709-15	2021	Most importantly, declined Tfr1 but increased Slc39a14 protein level on cellular membrane contributes to labile iron accumulation in skeletal muscle of aged rodents (~80 weeks old), leading to activation of ferroptosis in aged skeletal muscle.	Iron	112-116	solute carrier family 39 (zinc transporter), member 14	Mus musculus	46-54
4121289-10	1973	Evidence that N-acetylneuraminic acid groups are the principal acidic residues binding colloidal iron was the elimination of greater than 85% of the colloidal iron labeling to neuraminidase-treated cell membranes.	Iron	97-101	neuraminidase 1	Homo sapiens	176-189
33934496-3	2021	This study examines impacts of pH and the supply of acetate, sulfate, and goethite on the ratio of iron to sulfate reduction in semi-continuous sediment bioreactors.	Iron	99-103	phenylalanine hydroxylase	Homo sapiens	31-33
33934496-5	2021	Results show that pH had a greater influence than acetate supply on the ratio of iron to sulfate reduction, and that the impact of acetate supply on the ratio depended on pH.	Iron	81-85	phenylalanine hydroxylase	Homo sapiens	18-20
33934496-6	2021	In acidic reactors (pH 6.0 media), the ratio of iron to sulfate reduction decreased from 3:1 to 2:1 as acetate supply increased (0-1 mM).	Iron	48-52	phenylalanine hydroxylase	Homo sapiens	20-22
33934496-9	2021	Thus, the influence of sulfate supply on iron reduction extent also depended on pH and suggests that iron reduction grows more dependent on sulfate reduction as pH increases.	Iron	41-45	phenylalanine hydroxylase	Homo sapiens	80-82
33934496-9	2021	Thus, the influence of sulfate supply on iron reduction extent also depended on pH and suggests that iron reduction grows more dependent on sulfate reduction as pH increases.	Iron	41-45	phenylalanine hydroxylase	Homo sapiens	161-163
33934496-9	2021	Thus, the influence of sulfate supply on iron reduction extent also depended on pH and suggests that iron reduction grows more dependent on sulfate reduction as pH increases.	Iron	101-105	phenylalanine hydroxylase	Homo sapiens	80-82
33934496-9	2021	Thus, the influence of sulfate supply on iron reduction extent also depended on pH and suggests that iron reduction grows more dependent on sulfate reduction as pH increases.	Iron	101-105	phenylalanine hydroxylase	Homo sapiens	161-163
33934496-10	2021	Our results compare well to trends in groundwater geochemistry and provide further evidence that pH is a major control on iron and sulfate reduction in systems with crystalline (oxyhydr)oxides.	Iron	122-126	phenylalanine hydroxylase	Homo sapiens	97-99
33325950-2	2020	IRPs have broader physiological roles as some targeted mRNAs encode proteins with functions beyond iron metabolism suggesting hierarchical regulation of IRP-targeted mRNAs.	Iron	99-103	caspase 3	Rattus norvegicus	0-3
33325950-3	2020	We observe that the translational regulation of IRP-targeted mRNAs encoding iron storage (L- and H-ferritins) and export (ferroportin) proteins have different set-points of iron responsiveness compared to that for the TCA cycle enzyme mitochondrial aconitase.	Iron	76-80	caspase 3	Rattus norvegicus	48-51
33325950-3	2020	We observe that the translational regulation of IRP-targeted mRNAs encoding iron storage (L- and H-ferritins) and export (ferroportin) proteins have different set-points of iron responsiveness compared to that for the TCA cycle enzyme mitochondrial aconitase.	Iron	173-177	caspase 3	Rattus norvegicus	48-51
33351833-0	2020	Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation.	Iron	133-137	transferrin receptor	Homo sapiens	0-20
33351833-11	2020	Knockdown of TFR1 expression decreased iron accumulation and inhibited malignant behaviour.	Iron	39-43	transferrin receptor	Homo sapiens	13-17
33351833-13	2020	Additionally, knockdown of TFR1 expression decreased sphere formation by decreasing iron accumulation in CSCs, indicating a potential role for TFR1 in maintaining stemness.	Iron	84-88	transferrin receptor	Homo sapiens	27-31
4121289-10	1973	Evidence that N-acetylneuraminic acid groups are the principal acidic residues binding colloidal iron was the elimination of greater than 85% of the colloidal iron labeling to neuraminidase-treated cell membranes.	Iron	159-163	neuraminidase 1	Homo sapiens	176-189
33351833-14	2020	CONCLUSION: These findings, which revealed TFR1 as a critical regulator of LIHC CSCs in malignant behaviour and stemness that functions by regulating iron accumulation, may have implications to improve therapeutic approaches.	Iron	150-154	transferrin receptor	Homo sapiens	43-47
33929387-9	2021	Overexpression of PDSS2 suppressed the release of ROS, iron content and ferroptosis of HCAECs, and promoted the proliferation of HCAECs.	Iron	55-59	decaprenyl diphosphate synthase subunit 2	Homo sapiens	18-23
4188269-2	1970	In normal subjects, injected heme-(59)Fe was bound immediately by albumin and the beta(1)-globulin, hemopexin.	Iron	38-40	hemopexin	Homo sapiens	100-109
33959204-1	2021	Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of iron chelate of ethylenediamine (Iron-EDA-Cl) as a feed additive for all animal species.	Iron	127-131	ectodysplasin A	Homo sapiens	165-168
5193731-0	1969	The role of transferrin in placental iron transfer in the rabbit.	Iron	37-41	serotransferrin	Oryctolagus cuniculus	12-23
33889074-15	2021	Importantly, inhibiting ACSL4 could significantly attenuate the decline of GPx4 after MCAO and markedly attenuate iron accumulation and a decrease in GPx activity.	Iron	114-118	acyl-CoA synthetase long-chain family member 4	Mus musculus	24-29
5944900-0	1966	Iron and transferrin distribution and turnover in iron-overloaded rabbits.	Iron	50-54	serotransferrin	Oryctolagus cuniculus	9-20
33565643-1	2021	BACKGROUND: Cirrhosis develops in <10% of individuals homozygous for the C282Y variant in the homeostatic iron regulator (HFE) gene.	Iron	106-110	homeostatic iron regulator	Homo sapiens	122-125
33625078-2	2022	HFE-related hemochromatosis is characterized by excessive intestinal absorption of dietary iron, in particular cases resulting in pathologically high iron storage in tissues and organs.	Iron	91-95	homeostatic iron regulator	Homo sapiens	0-3
14186750-0	1964	SPECIFIC INHIBITION OF HEPATIC GLUCOSE-6-PHOSPHATE DEHYDROGENASE IN IRON DEFICIENCY ANEMIA IN ALBINO RATS.	Iron	68-72	glucose-6-phosphate dehydrogenase	Rattus norvegicus	31-64
33625078-2	2022	HFE-related hemochromatosis is characterized by excessive intestinal absorption of dietary iron, in particular cases resulting in pathologically high iron storage in tissues and organs.	Iron	150-154	homeostatic iron regulator	Homo sapiens	0-3
14120960-0	1964	"STONE WALLS AND IRON BARS".	Iron	17-21	C-terminal binding protein 1	Homo sapiens	22-27
28613612-0	2022	Hemochromatosis Hemochromatosis is a disorder associated with deposits of an excess of iron causing dysfunction of multiple organs.	Iron	87-91	homeostatic iron regulator	Homo sapiens	0-15
28613612-2	2022	Hemochromatosis occurs when there are high pathologic levels of iron accumulation in the body.	Iron	64-68	homeostatic iron regulator	Homo sapiens	0-15
17809382-0	1950	Studies on the Metabolism of Administered Cytochrome C by the Aid of Iron-labeled Cytochrome.	Iron	69-73	activation induced cytidine deaminase	Homo sapiens	62-65
33722571-3	2021	Here, we show that ferroptosis, a form of regulated cell death driven by iron-dependent phospholipid peroxidation, is partly responsible for the efficacy of PARP inhibitor olaparib.	Iron	73-77	collagen type XI alpha 2 chain	Homo sapiens	157-161
34047695-0	2021	Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2.	Iron	92-96	absent in melanoma 2	Mus musculus	118-122
34044117-6	2021	The distance between heme-iron and omega6 (C14, C15) double bond of AA in OBS also increased from 7.5 +- 1.4 A to 8.5 +- 1.8 A when CYP2J2 was simulated with only AA in OBS versus the presence of AA in both OBS and SBS (p<0.001), supporting the observed in vitro substrate inhibition phenomenon.	Iron	26-30	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	132-138
34011924-6	2021	Mechanically, MYCN expression reprograms the cellular iron metabolism by upregulating the expression of TFRC, which encodes transferrin receptor 1 as a key iron transporter on the cell membrane.	Iron	156-160	transferrin receptor	Homo sapiens	104-108
33535005-3	2021	Cytosolic aconitase (ACO1) upon losing an iron-sulfur cluster becomes iron regulatory protein 1 (IRP1).	Iron	42-46	aconitase 1	Rattus norvegicus	21-25
33535005-3	2021	Cytosolic aconitase (ACO1) upon losing an iron-sulfur cluster becomes iron regulatory protein 1 (IRP1).	Iron	42-46	aconitase 1	Rattus norvegicus	70-95
33535005-3	2021	Cytosolic aconitase (ACO1) upon losing an iron-sulfur cluster becomes iron regulatory protein 1 (IRP1).	Iron	42-46	aconitase 1	Rattus norvegicus	97-101
33535005-5	2021	An increase in iron leads to inactivation of IRP1.	Iron	15-19	aconitase 1	Rattus norvegicus	45-49
33535005-9	2021	Iron supplementation will increase iron-sulfur cluster formation switching IRP1 to ACO1.	Iron	0-4	aconitase 1	Rattus norvegicus	75-79
33535005-9	2021	Iron supplementation will increase iron-sulfur cluster formation switching IRP1 to ACO1.	Iron	0-4	aconitase 1	Rattus norvegicus	83-87
33535005-9	2021	Iron supplementation will increase iron-sulfur cluster formation switching IRP1 to ACO1.	Iron	35-39	aconitase 1	Rattus norvegicus	75-79
33535005-9	2021	Iron supplementation will increase iron-sulfur cluster formation switching IRP1 to ACO1.	Iron	35-39	aconitase 1	Rattus norvegicus	83-87
33535005-10	2021	With IRP1 levels kept constantly low, iron utilization will systematically be tightly regulated stopping dysregulation of complex 1 and the neural damage done by rotenone preventing PD.	Iron	38-42	aconitase 1	Rattus norvegicus	5-9
34012978-4	2021	Here, we demonstrated that transferrin receptor (TfRC) which is critical for the iron import of cells was degraded via autophagy.	Iron	81-85	transferrin receptor	Homo sapiens	27-47
34012978-4	2021	Here, we demonstrated that transferrin receptor (TfRC) which is critical for the iron import of cells was degraded via autophagy.	Iron	81-85	transferrin receptor	Homo sapiens	49-53
34012978-6	2021	The intracellular iron content was increased in cells overexpressing TfRC or mutant WDR45, however, ferritin H (FTH) chain was decreased.	Iron	18-22	transferrin receptor	Homo sapiens	69-73
33517471-4	2021	The production of FGF23 is regulated by 1,25(OH)2D3, parathyroid hormone, dietary phosphate intake, iron status, as well as inflammation.	Iron	100-104	fibroblast growth factor 23	Rattus norvegicus	18-23
33739421-2	2021	We recently observed that the murine homologue to the human H63D variant of the homeostatic iron regulator (HFE) may decrease paraquat-associated nigral neurotoxicity in mice.	Iron	92-96	homeostatic iron regulator	Homo sapiens	108-111
33883134-2	2021	We show that AFD and FE modes are cooperatively coupled in LAO/STO (111) heterostructures; they coexist below the critical thickness (t c) and disappear simultaneously above t c with the formation of 2DEG.	Iron	21-23	interleukin 4 induced 1	Homo sapiens	59-62
33876884-7	2021	Fe-scaffold was found to promote the cell adhesion compared with Uncoated-scaffold, including increasing the adhered cell number, promoting cell spreading and upregulating the expression levels of adhesion-related genes integrin alpha1 and beta1 and their downstream signaling molecules FAK and ERK1/2 (p < 0.05).	Iron	0-2	mitogen activated protein kinase 3	Rattus norvegicus	295-301
33870790-2	2022	OBJECTIVE: To assess the relationship between iron rims and levels of chitinase 3-like 1 (CHI3L1), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with a first demyelinating event.	Iron	46-50	chitinase 3 like 1	Homo sapiens	70-88
33870790-2	2022	OBJECTIVE: To assess the relationship between iron rims and levels of chitinase 3-like 1 (CHI3L1), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with a first demyelinating event.	Iron	46-50	chitinase 3 like 1	Homo sapiens	90-96
33870790-8	2022	In univariable analysis, having >=2 iron rims (vs 0) was associated with increased CSF CHI3L1 levels (beta = 1.41; 95% confidence interval (CI) = 1.10-1.79; p < 0.01) and serum NfL levels (beta = 2.30; 95% CI = 1.47-3.60; p < 0.01).	Iron	36-40	chitinase 3 like 1	Homo sapiens	87-93
33870790-9	2022	In multivariable analysis, however, only CSF CHI3L1 levels remained significantly associated with the presence of iron rim lesions (beta = 1.45; 95% CI = 1.11-1.90; p < 0.01).	Iron	114-118	chitinase 3 like 1	Homo sapiens	45-51
33933762-6	2021	Under optimal conditions of material (Fe@C-NB) syntheses, both 95% degradation of p-ASA and 86% total arsenic immobilization can be obtained with oxidant (Peroxymonosulfate, PMS) and catalyst (Fe@C-NB) treatment after 60 min.	Iron	38-40	proline rich protein BstNI subfamily 1	Homo sapiens	174-177
33933762-8	2021	In this Fenton-like reaction, the Fe@C-NB exhibits high efficiency and excellent stability without complex preparation methods; besides, the advantages of short reaction time and natural reaction conditions in Fe@C-NB/PMS system will promote the practical application of Fenton-like.	Iron	8-10	proline rich protein BstNI subfamily 1	Homo sapiens	218-221
33933762-8	2021	In this Fenton-like reaction, the Fe@C-NB exhibits high efficiency and excellent stability without complex preparation methods; besides, the advantages of short reaction time and natural reaction conditions in Fe@C-NB/PMS system will promote the practical application of Fenton-like.	Iron	34-36	proline rich protein BstNI subfamily 1	Homo sapiens	218-221
33529321-0	2021	Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich"s ataxia fibroblasts.	Iron	58-62	transferrin receptor	Homo sapiens	28-48
33529321-1	2021	Friedreich"s ataxia (FRDA) is a frequent autosomal recessive disease caused by a GAA repeat expansion in the FXN gene encoding frataxin, a mitochondrial protein involved in iron-sulfur cluster (ISC) biogenesis.	Iron	173-177	frataxin	Homo sapiens	109-112
33529321-1	2021	Friedreich"s ataxia (FRDA) is a frequent autosomal recessive disease caused by a GAA repeat expansion in the FXN gene encoding frataxin, a mitochondrial protein involved in iron-sulfur cluster (ISC) biogenesis.	Iron	173-177	frataxin	Homo sapiens	127-135
33529321-2	2021	Resulting frataxin deficiency affects ISC-containing proteins and causes iron to accumulate in the brain and heart of FRDA patients.	Iron	73-77	frataxin	Homo sapiens	10-18
33999585-2	2021	A 4mm punch biopsy revealed interstitial granulomatous inflammation within the dermis and a colloidal iron stain showed increased dermal acid mucin.	Iron	102-106	LOC100508689	Homo sapiens	142-147
33783066-0	2021	Limits of Fat Quantification in the Presence of Iron Overload.	Iron	48-52	FAT atypical cadherin 1	Homo sapiens	10-13
33783066-1	2021	BACKGROUND: Chemical shift encoded magnetic resonance imaging (CSE-MRI)-based tissue fat quantification is confounded by increased R2* signal decay rate caused by the presence of excess iron deposition.	Iron	186-190	FAT atypical cadherin 1	Homo sapiens	85-88
33850218-9	2021	Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice.	Iron	128-132	fibroblast growth factor 21	Mus musculus	21-26
33742450-1	2021	Ferredoxin reductase (FDXR), located in 17q25.1, encodes for a mitochondrial NADPH: adrenodoxin oxidoreductase or ferredoxin reductase, the sole human ferredoxin reductase involved in the biosynthesis of iron-sulfur (Fe-S) clusters and heme formation.	Iron	217-221	ferredoxin reductase	Homo sapiens	0-20
33742450-1	2021	Ferredoxin reductase (FDXR), located in 17q25.1, encodes for a mitochondrial NADPH: adrenodoxin oxidoreductase or ferredoxin reductase, the sole human ferredoxin reductase involved in the biosynthesis of iron-sulfur (Fe-S) clusters and heme formation.	Iron	217-221	ferredoxin reductase	Homo sapiens	22-26
33742450-1	2021	Ferredoxin reductase (FDXR), located in 17q25.1, encodes for a mitochondrial NADPH: adrenodoxin oxidoreductase or ferredoxin reductase, the sole human ferredoxin reductase involved in the biosynthesis of iron-sulfur (Fe-S) clusters and heme formation.	Iron	217-221	ferredoxin reductase	Homo sapiens	114-134
33742450-1	2021	Ferredoxin reductase (FDXR), located in 17q25.1, encodes for a mitochondrial NADPH: adrenodoxin oxidoreductase or ferredoxin reductase, the sole human ferredoxin reductase involved in the biosynthesis of iron-sulfur (Fe-S) clusters and heme formation.	Iron	217-221	ferredoxin reductase	Homo sapiens	151-171
32659785-0	2020	NCOA4 is Regulated by HIF and Mediates Mobilization of Murine Hepatic Iron Stores After Blood Loss.	Iron	70-74	nuclear receptor coactivator 4	Mus musculus	0-5
32659785-3	2020	Here, we investigate a local requirement for NCOA4 in the regulation of hepatic iron stores and examine mechanisms of NCOA4 regulation.	Iron	80-84	nuclear receptor coactivator 4	Mus musculus	45-50
32659785-5	2020	After phlebotomy, mice with hepatocyte-targeted Ncoa4 knockdown exhibited anemia and hypoferremia similar to control mice with intact Ncoa4 regulation, but showed a markedly impaired ability to lower hepatic ferritin subunit levels and hepatic non-heme iron concentration.	Iron	253-257	nuclear receptor coactivator 4	Mus musculus	48-53
32659785-9	2020	In summary, we show for the first time that NCOA4 plays a local role in facilitating iron mobilization from the liver after blood loss and that HIF regulates NCOA4 expression in cells of hepatic origin.	Iron	85-89	nuclear receptor coactivator 4	Mus musculus	44-49
33850218-9	2021	Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice.	Iron	128-132	fibroblast growth factor 21	Mus musculus	71-76
32659785-10	2020	Because the prolyl hydroxylases that regulate HIF stability are oxygen and iron-dependent enzymes, our findings suggest a novel mechanism by which hypoxia and iron deficiency may modulate NCOA4 expression to impact iron homeostasis.	Iron	75-79	nuclear receptor coactivator 4	Mus musculus	188-193
32659785-10	2020	Because the prolyl hydroxylases that regulate HIF stability are oxygen and iron-dependent enzymes, our findings suggest a novel mechanism by which hypoxia and iron deficiency may modulate NCOA4 expression to impact iron homeostasis.	Iron	159-163	nuclear receptor coactivator 4	Mus musculus	188-193
33850218-9	2021	Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice.	Iron	128-132	fibroblast growth factor 21	Mus musculus	71-76
33159788-6	2021	Analysis of the Fe homeostasis transcriptional cascade revealed that H2O2 influences the gene expression of downstream regulators FIT, BHLHs of group Ib and POPEYE (PYE), however H2O2 did not affect their upstream regulators, such as BHLH104 and ILR3.	Iron	16-18	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	246-250
33538226-3	2021	Recently, we showed that MYB28 and MYB29 transcription factors play a role in ammonium tolerance, since its double mutant (myb28myb29) is highly hypersensitive toward ammonium nutrition in relation to altered Fe homeostasis.	Iron	209-211	myb domain protein 28	Arabidopsis thaliana	25-30
33188427-7	2021	Mutants opt3 and frd1, which display misregulated Fe homeostasis under Fe sufficient conditions, show disease resistance levels comparable to those of Fe-starved wild-type plants.	Iron	50-52	oligopeptide transporter	Arabidopsis thaliana	8-12
33188427-7	2021	Mutants opt3 and frd1, which display misregulated Fe homeostasis under Fe sufficient conditions, show disease resistance levels comparable to those of Fe-starved wild-type plants.	Iron	50-52	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
33242392-4	2020	We demonstrate that fSHAPE patterns predict binding sites of known RBPs, such as iron response elements in both known loci and previously unknown loci in CDC34, SLC2A4RG, COASY, and H19.	Iron	81-85	SLC2A4 regulator	Homo sapiens	161-169
33795032-5	2021	Fasted mice as well as forskolin (FSK)- and glucagon (GLU)-treated mice had reduced serum iron levels but increased expression levels of hepatic Crbn and Klf15 and hepcidin secretion.	Iron	90-94	glucagon	Mus musculus	44-52
33148716-7	2020	In the current study, we report that interaction of the ESAT-6 protein with beta2M causes downregulation of surface HFE, a protein regulating iron homeostasis via interacting with transferrin receptor 1 (TFR1).	Iron	142-146	transferrin receptor	Mus musculus	204-208
33438034-8	2021	In Study 2, we found a significant increase in the aortic plasma concentration of lipocalin 2 (LCN2; +65%; P < 0.001), an iron-trafficking protein.	Iron	122-126	lipocalin 2	Rattus norvegicus	82-93
33438034-8	2021	In Study 2, we found a significant increase in the aortic plasma concentration of lipocalin 2 (LCN2; +65%; P < 0.001), an iron-trafficking protein.	Iron	122-126	lipocalin 2	Rattus norvegicus	95-99
33438034-11	2021	LCN2 may be responsible for the hepatic iron-lowering effect of primary 12alphaOH BAs by transporting iron out of the liver.	Iron	40-44	lipocalin 2	Rattus norvegicus	0-4
33438034-11	2021	LCN2 may be responsible for the hepatic iron-lowering effect of primary 12alphaOH BAs by transporting iron out of the liver.	Iron	102-106	lipocalin 2	Rattus norvegicus	0-4
32823164-13	2020	The median of the estimated median iron requirement was 8.12 mg, 8.15 mg and 8.18 mg for women aged 18-29 years, respectively, as the exact numerical estimate, the approximate estimate using BETA.INV in Excel and the approximate estimate using F.INV in Excel.	Iron	35-39	inversin	Homo sapiens	196-199
33497677-1	2021	In this study, a reduced g-C3N4/PDI/Fe (R-gCPF) photocatalyst was synthesized by loading Fe ion onto a reduced g-C3N4/PDI (R-gCP), which was obtained by reducing g-C3N4/PDI with NaBH4.	Iron	36-38	prolyl 4-hydroxylase subunit beta	Homo sapiens	32-35
32746765-2	2020	Hepcidin is an endogenous peptide hormone that serves as a key regulator of iron metabolism, and ferroportin and ZIP8 are iron transporters.	Iron	122-126	solute carrier family 39 member 8	Homo sapiens	113-117
33683742-9	2021	Nuclear factor erythroid 2-related factor 2 (Nrf2) activated subunits of glutamate cysteine ligase (Gclc) and glutathione S-transferase A1 (Gsta1) upregulation in the UL iron group liver, thereby increasing resistance to oxidative stress.	Iron	170-174	glutamate-cysteine ligase catalytic subunit	Homo sapiens	100-104
33683742-9	2021	Nuclear factor erythroid 2-related factor 2 (Nrf2) activated subunits of glutamate cysteine ligase (Gclc) and glutathione S-transferase A1 (Gsta1) upregulation in the UL iron group liver, thereby increasing resistance to oxidative stress.	Iron	170-174	glutathione S-transferase alpha 1	Homo sapiens	110-138
33683742-9	2021	Nuclear factor erythroid 2-related factor 2 (Nrf2) activated subunits of glutamate cysteine ligase (Gclc) and glutathione S-transferase A1 (Gsta1) upregulation in the UL iron group liver, thereby increasing resistance to oxidative stress.	Iron	170-174	glutathione S-transferase alpha 1	Homo sapiens	140-145
31050314-10	2021	Finally, we showed that iron and 1-Methyl-4-phenylpyridinium (MPP+) co-treatment significantly increased superoxide production in microglial cultures by inducing p38 mitogen-activated protein kinase (MAPK) activation.	Iron	24-28	mitogen-activated protein kinase 14	Mus musculus	162-165
31050314-11	2021	BA also significantly decreased superoxide production and p38 MAPK phosphorylation in the cultures co-treated with iron and MPP+.	Iron	115-119	mitogen-activated protein kinase 14	Mus musculus	58-66
32151295-9	2020	Nut consumption was associated with significantly greater intakes of fibre, vitamin E, Fe, Mg and P.	Iron	87-89	NUT midline carcinoma family member 1	Homo sapiens	0-3
33497677-1	2021	In this study, a reduced g-C3N4/PDI/Fe (R-gCPF) photocatalyst was synthesized by loading Fe ion onto a reduced g-C3N4/PDI (R-gCP), which was obtained by reducing g-C3N4/PDI with NaBH4.	Iron	36-38	prolyl 4-hydroxylase subunit beta	Homo sapiens	118-121
33497677-1	2021	In this study, a reduced g-C3N4/PDI/Fe (R-gCPF) photocatalyst was synthesized by loading Fe ion onto a reduced g-C3N4/PDI (R-gCP), which was obtained by reducing g-C3N4/PDI with NaBH4.	Iron	36-38	prolyl 4-hydroxylase subunit beta	Homo sapiens	118-121
33497677-1	2021	In this study, a reduced g-C3N4/PDI/Fe (R-gCPF) photocatalyst was synthesized by loading Fe ion onto a reduced g-C3N4/PDI (R-gCP), which was obtained by reducing g-C3N4/PDI with NaBH4.	Iron	89-91	prolyl 4-hydroxylase subunit beta	Homo sapiens	32-35
32976958-7	2020	Both HFD-fed mice and PA/OA-induced HepG2 cells displayed ferroptosis-based panel of biomarkers such as iron overload with the up-regulation of TFR1 and the down-regulation of FTH1, lipid peroxidation and inhibition of Nrf2 activity, which further induced GPX4 and HO-1 levels.	Iron	104-108	transferrin receptor	Homo sapiens	144-148
33497677-1	2021	In this study, a reduced g-C3N4/PDI/Fe (R-gCPF) photocatalyst was synthesized by loading Fe ion onto a reduced g-C3N4/PDI (R-gCP), which was obtained by reducing g-C3N4/PDI with NaBH4.	Iron	89-91	prolyl 4-hydroxylase subunit beta	Homo sapiens	118-121
33631196-2	2021	Iron regulatory proteins (IRP) 1 and 2 are RNA-binding proteins that regulate intracellular iron homeostasis.	Iron	92-96	aconitase 1	Homo sapiens	0-38
33497677-1	2021	In this study, a reduced g-C3N4/PDI/Fe (R-gCPF) photocatalyst was synthesized by loading Fe ion onto a reduced g-C3N4/PDI (R-gCP), which was obtained by reducing g-C3N4/PDI with NaBH4.	Iron	89-91	prolyl 4-hydroxylase subunit beta	Homo sapiens	118-121
33710119-10	2021	miR-210 and miR-122 collectively play a role in maintaining the iron balance.	Iron	64-68	microRNA 210	Homo sapiens	0-7
33526170-3	2021	Iron release from ferritin storage is through nuclear receptor coactivator 4 (NCOA4)-mediated autophagic degradation, known as ferritinophagy.	Iron	0-4	nuclear receptor coactivator 4	Mus musculus	46-76
32678895-7	2020	Treatment of UROS-deficient erythroid cell lines and peripheral blood CD34+-derived erythroid cultures from a CEP patient with deferiprone inhibited iron-dependent protein ALAS2 and IRP2 expression and reduced porphyrin production.	Iron	149-153	uroporphyrinogen III synthase	Homo sapiens	13-17
32678895-7	2020	Treatment of UROS-deficient erythroid cell lines and peripheral blood CD34+-derived erythroid cultures from a CEP patient with deferiprone inhibited iron-dependent protein ALAS2 and IRP2 expression and reduced porphyrin production.	Iron	149-153	5'-aminolevulinate synthase 2	Homo sapiens	172-177
33280130-5	2021	In mitochondria and chloroplast, the iron metabolism and its transport across the membrane are mediated by ABC transporters.	Iron	37-41	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	107-110
32678427-1	2020	BACKGROUND: The predominant bean iron (Fe) biofortification approach is to breed for high Fe concentration and assumes the average Fe concentration is 50 mug/g.	Iron	33-37	homeostatic iron regulator	Homo sapiens	85-92
32678427-1	2020	BACKGROUND: The predominant bean iron (Fe) biofortification approach is to breed for high Fe concentration and assumes the average Fe concentration is 50 mug/g.	Iron	39-41	homeostatic iron regulator	Homo sapiens	85-92
32678427-3	2020	OBJECTIVE: The overall objective was to determine if bean Fe biofortification via breeding for high Fe is producing beans with higher Fe concentration relative to nonbiofortified lines found in the East Africa marketplace.	Iron	58-60	homeostatic iron regulator	Homo sapiens	95-102
33573082-8	2021	By contrast, both of them upregulate the Fe acquisition genes FRO2 and IRT1 (and FIT) under Fe deficiency.	Iron	41-43	ferric reduction oxidase 2	Arabidopsis thaliana	62-66
33404288-8	2021	Additionally, the intracellular iron exporter SLC40A1 was identified as a new substrate for autophagic elimination, and its degradation by SQSTM1 promoted ferroptosis in vitro and in xenograft tumor mouse models.	Iron	32-36	sequestosome 1	Mus musculus	139-145
33213020-1	2020	The paper reports the synthesis of carbon nanotubes from ethanol over group VIII (Fe, Co, Ni) catalysts derived from corresponding metallocenes.	Iron	82-84	cytochrome c oxidase subunit 8A	Homo sapiens	76-80
33493903-3	2021	Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1.	Iron	52-56	transferrin receptor	Mus musculus	180-202
32989015-8	2020	Mitochondrial instability in the FANCGR22P cell causes the transcriptional down-regulation of mitochondrial iron-sulfur cluster biogenesis protein Frataxin (FXN) and resulting iron deficiency of FA protein FANCJ, an iron-sulfur containing helicase involved in DNA repair.	Iron	108-112	frataxin	Homo sapiens	147-155
32989015-8	2020	Mitochondrial instability in the FANCGR22P cell causes the transcriptional down-regulation of mitochondrial iron-sulfur cluster biogenesis protein Frataxin (FXN) and resulting iron deficiency of FA protein FANCJ, an iron-sulfur containing helicase involved in DNA repair.	Iron	108-112	frataxin	Homo sapiens	157-160
33405076-16	2021	Moreover, iron overload increased ROS production and Nox4 expression.	Iron	10-14	NADPH oxidase 4	Mus musculus	53-57
33405106-4	2021	Also, it was revealed that the mean DF has a direct and significant relationship with temperature, wind speed, and relative humidity.The elements of Fe (11,997-17,093 mg/Kg and 71-81%) and Al (2903-6852 mg/Kg and 14-25%), which are the main elements of the Earth crust, were the dominant metals of DF among the analyzed elements.	Iron	149-151	complement factor D	Homo sapiens	36-38
33493903-3	2021	Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1.	Iron	52-56	transferrin receptor	Mus musculus	204-208
33625078-8	2022	In conclusion, this preliminary study demonstrates an impaired impact of endogenous EPO on erythropoiesis in the presence of increased iron content in carriers of p.(His63Asp) (heterozygotes) variant of the HFE gene in developmental age.	Iron	135-139	homeostatic iron regulator	Homo sapiens	207-210
32112499-8	2020	These changes were accompanied by upregulation of iron regulatory protein 2 (IRP-2), which led to an increase in transferrin receptor 1 (TfR-1), thus increasing iron entry into cells and potentially leading to ferroptosis.	Iron	50-54	transferrin receptor	Homo sapiens	113-135
33898949-0	2021	Roquin is a major mediator of iron-regulated changes to transferrin receptor-1 mRNA stability.	Iron	30-34	transferrin receptor	Homo sapiens	56-78
32112499-8	2020	These changes were accompanied by upregulation of iron regulatory protein 2 (IRP-2), which led to an increase in transferrin receptor 1 (TfR-1), thus increasing iron entry into cells and potentially leading to ferroptosis.	Iron	50-54	transferrin receptor	Homo sapiens	137-142
32873629-5	2020	Interestingly, the AHA2 proton pump and the FRO2 reductase, both of which work in concert with IRT1 in the acidification-reduction-transport strategy of iron uptake, were part of this interactome.	Iron	153-157	ferric reduction oxidase 2	Arabidopsis thaliana	44-48
33898949-1	2021	Transferrin receptor-1 (TfR1) has essential iron transport and proposed signal transduction functions.	Iron	44-48	transferrin receptor	Homo sapiens	0-22
32873629-7	2020	We characterized the dynamics of the iron uptake complex and showed that FRO2 and AHA2 ubiquitination is independent of the non-iron metal substrates transported by IRT1.	Iron	37-41	ferric reduction oxidase 2	Arabidopsis thaliana	73-77
33898949-1	2021	Transferrin receptor-1 (TfR1) has essential iron transport and proposed signal transduction functions.	Iron	44-48	transferrin receptor	Homo sapiens	24-28
33898949-4	2021	Here, we show with gene knockouts and siRNA knockdowns that two Roquin paralogs are major mediators of iron-regulated changes to the steady-state TfR1 mRNA level within four different cell types (HAP1, HUVEC, L-M, and MEF).	Iron	103-107	transferrin receptor	Homo sapiens	146-150
33898949-5	2021	Roquin is demonstrated to destabilize the TfR1 mRNA, and its activity is fully dependent on three hairpin loops within the TfR1 mRNA 3"-UTR that are essential for iron-regulated instability.	Iron	163-167	transferrin receptor	Homo sapiens	123-127
32943465-10	2020	Our results demonstrate that NFS1 and its interactor FH are involved not only in nonhost resistance but also in basal resistance, suggesting a new role of the Fe-S cluster pathway in plant immunity.	Iron	159-163	frataxin-like protein	Arabidopsis thaliana	53-55
34027264-9	2021	The most common form of HH is due to a mutation in the HFE gene, which causes a failure in the hepatocyte iron-sensing mechanism, leading to reduced hepcidin expression; the clinical manifestations of HFE-HH include increased serum transferrin-iron saturation and progressive iron loading in the liver and other tissues over time among patients who express the disease phenotype.	Iron	106-110	homeostatic iron regulator	Homo sapiens	55-58
32492604-4	2020	Subsequently, lysosomal dysfunction mediated by iron increased mitochondrial membrane permeability and decreased mitochondrial membrane potential, thereby enhancing Bid and cytochrome c release and caspase-9/-3 activation (P < 0.05).	Iron	48-52	LOC104968582	Bos taurus	173-185
34027264-9	2021	The most common form of HH is due to a mutation in the HFE gene, which causes a failure in the hepatocyte iron-sensing mechanism, leading to reduced hepcidin expression; the clinical manifestations of HFE-HH include increased serum transferrin-iron saturation and progressive iron loading in the liver and other tissues over time among patients who express the disease phenotype.	Iron	106-110	homeostatic iron regulator	Homo sapiens	201-204
32492604-4	2020	Subsequently, lysosomal dysfunction mediated by iron increased mitochondrial membrane permeability and decreased mitochondrial membrane potential, thereby enhancing Bid and cytochrome c release and caspase-9/-3 activation (P < 0.05).	Iron	48-52	caspase 9	Bos taurus	198-207
34027264-9	2021	The most common form of HH is due to a mutation in the HFE gene, which causes a failure in the hepatocyte iron-sensing mechanism, leading to reduced hepcidin expression; the clinical manifestations of HFE-HH include increased serum transferrin-iron saturation and progressive iron loading in the liver and other tissues over time among patients who express the disease phenotype.	Iron	244-248	homeostatic iron regulator	Homo sapiens	55-58
34027264-9	2021	The most common form of HH is due to a mutation in the HFE gene, which causes a failure in the hepatocyte iron-sensing mechanism, leading to reduced hepcidin expression; the clinical manifestations of HFE-HH include increased serum transferrin-iron saturation and progressive iron loading in the liver and other tissues over time among patients who express the disease phenotype.	Iron	244-248	homeostatic iron regulator	Homo sapiens	201-204
34027264-9	2021	The most common form of HH is due to a mutation in the HFE gene, which causes a failure in the hepatocyte iron-sensing mechanism, leading to reduced hepcidin expression; the clinical manifestations of HFE-HH include increased serum transferrin-iron saturation and progressive iron loading in the liver and other tissues over time among patients who express the disease phenotype.	Iron	244-248	homeostatic iron regulator	Homo sapiens	55-58
34027264-9	2021	The most common form of HH is due to a mutation in the HFE gene, which causes a failure in the hepatocyte iron-sensing mechanism, leading to reduced hepcidin expression; the clinical manifestations of HFE-HH include increased serum transferrin-iron saturation and progressive iron loading in the liver and other tissues over time among patients who express the disease phenotype.	Iron	244-248	homeostatic iron regulator	Homo sapiens	201-204
32800558-7	2020	Further study indicated that all the rescue effects of Tsf1 knockdown on sporadic PD could be inhibited by malvolio (Mvl) overexpression, an iron transporter responsible for iron uptake.	Iron	141-145	Transferrin 1	Drosophila melanogaster	55-59
32800558-7	2020	Further study indicated that all the rescue effects of Tsf1 knockdown on sporadic PD could be inhibited by malvolio (Mvl) overexpression, an iron transporter responsible for iron uptake.	Iron	174-178	Transferrin 1	Drosophila melanogaster	55-59
32800558-8	2020	These results imply that Tsf1 knockdown in the CNS could attenuate rotenone toxicity by decreasing the ROS levels in brains through reducing iron levels, and manipulation of iron transporters in brains may provide a novel therapeutic strategy for sporadic PD.	Iron	141-145	Transferrin 1	Drosophila melanogaster	25-29
33897873-20	2021	Finally, a varying degree of secondary labile iron increase is caused by the failure to sustain YAP-stimulated transcriptional compensation for ferritin at later stages further explains why ferroptosis sensitivity varies among LUAD cells.	Iron	46-50	Yes1 associated transcriptional regulator	Homo sapiens	96-99
33123307-8	2020	ROS induced by iron overload promote necroptosis via a positive feedback mechanism, as on the one hand N-acetylcysteine attenuates the upregulation of RIPK1 and RIPK3 and phosphorylation of RIPK1, RIPK3, and MLKL and on the other hand Nec-1, siRIPK1, or siRIPK3 reduced ROS generation.	Iron	15-19	mixed lineage kinase domain like pseudokinase	Homo sapiens	208-212
33123307-9	2020	In summary, iron overload induced necroptosis of osteoblastic cells in vitro, which is mediated, at least in part, through the RIPK1/RIPK3/MLKL pathway.	Iron	12-16	mixed lineage kinase domain like pseudokinase	Homo sapiens	139-143
33704303-2	2021	The results show that the ground states of Fe, Cr mono-doped SnS2 are spin polarized, and the magnetic moments caused are 1.99 muB and 3.00 muB, respectively.	Iron	43-45	sodium voltage-gated channel alpha subunit 11	Homo sapiens	61-65
33704303-3	2021	The magnetic moment of Fe mono-doped SnS2 is mainly produced by Fe:3d orbitals, and the magnetic moment of Cr mono-doped SnS2 is mainly produced by Cr:3d and Sn:4d orbitals.	Iron	23-25	sodium voltage-gated channel alpha subunit 11	Homo sapiens	37-41
33057367-2	2020	This study evaluated the role of iron in a previously reported association of iron-loading hemochromatosis (HFE) gene variants with reduced risk of neuropathy in PWH who received more neurotoxic cART, since an iron-related mechanism also might be relevant to neuropathic symptoms in PWH living in low-resource settings today.	Iron	33-37	homeostatic iron regulator	Homo sapiens	108-111
33057367-2	2020	This study evaluated the role of iron in a previously reported association of iron-loading hemochromatosis (HFE) gene variants with reduced risk of neuropathy in PWH who received more neurotoxic cART, since an iron-related mechanism also might be relevant to neuropathic symptoms in PWH living in low-resource settings today.	Iron	78-82	homeostatic iron regulator	Homo sapiens	108-111
33704303-3	2021	The magnetic moment of Fe mono-doped SnS2 is mainly produced by Fe:3d orbitals, and the magnetic moment of Cr mono-doped SnS2 is mainly produced by Cr:3d and Sn:4d orbitals.	Iron	64-66	sodium voltage-gated channel alpha subunit 11	Homo sapiens	37-41
33057367-2	2020	This study evaluated the role of iron in a previously reported association of iron-loading hemochromatosis (HFE) gene variants with reduced risk of neuropathy in PWH who received more neurotoxic cART, since an iron-related mechanism also might be relevant to neuropathic symptoms in PWH living in low-resource settings today.	Iron	78-82	homeostatic iron regulator	Homo sapiens	108-111
33057367-7	2020	Carriers of HFE variants had higher systemic iron (lower sTFR and sTFR-ferritin index) and lower hsCRP levels than non-carriers (all p<0.05).	Iron	45-49	homeostatic iron regulator	Homo sapiens	12-15
33704303-4	2021	We calculate that in the (Fe, Cr) co-doped SnS2 system, Fe, Cr and the adjacent S atoms form a strong hybrid, that is, the closest S atom between Fe and Cr atoms mediates the spin polarization and ferromagnetic (FM) coupling.	Iron	26-28	sodium voltage-gated channel alpha subunit 11	Homo sapiens	43-47
33704303-4	2021	We calculate that in the (Fe, Cr) co-doped SnS2 system, Fe, Cr and the adjacent S atoms form a strong hybrid, that is, the closest S atom between Fe and Cr atoms mediates the spin polarization and ferromagnetic (FM) coupling.	Iron	56-58	sodium voltage-gated channel alpha subunit 11	Homo sapiens	43-47
33704303-4	2021	We calculate that in the (Fe, Cr) co-doped SnS2 system, Fe, Cr and the adjacent S atoms form a strong hybrid, that is, the closest S atom between Fe and Cr atoms mediates the spin polarization and ferromagnetic (FM) coupling.	Iron	56-58	sodium voltage-gated channel alpha subunit 11	Homo sapiens	43-47
32989163-0	2020	Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates.	Iron	59-63	alkB homolog 5, RNA demethylase	Homo sapiens	64-70
33704303-5	2021	This promotes the formation of a Fe:3d-S:3p-Cr:3d coupling chain, so that (Fe, Cr) co-doped SnS2 obtains FM stability.	Iron	33-35	sodium voltage-gated channel alpha subunit 11	Homo sapiens	92-96
33704303-8	2021	In summary, Fe, Cr doped SnS2 dilute magnetic semiconductors may be a good candidate in the field of spintronic devices.	Iron	12-14	sodium voltage-gated channel alpha subunit 11	Homo sapiens	25-29
33867840-7	2021	Finally, monomeric MnSOD, as modeled by amber codon substitution to generate MnSOD-K68-Ac or MnSOD-K68Q expression in mammalian cells, appeared to incorporate Fe to maximally induce its peroxidase activity.	Iron	159-161	superoxide dismutase 2	Homo sapiens	19-24
33025115-5	2020	Based on ESP maps, doping of Cr, Ti, Fe, and Ni is the cause of strong electrophilic region creation which is very useful for adsorption process CH2Cl2 and CHCl3 on nanocages.	Iron	37-39	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	9-12
33737539-9	2021	In addition, PAX8, an important target in HGSOC and a potential miRNA target (from IPA) was epigenetically deregulated in iron-exposed FTSECs.	Iron	122-126	paired box 8	Homo sapiens	13-17
32970420-0	2020	Hydroxylamine Complexes of Cytochrome c": Influence of Heme Iron Redox State on Kinetic and Spectroscopic Properties.	Iron	60-64	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	27-39
33729329-7	2021	Cd, Cr and Fe were correlated positively with CAT and negatively with TBARS and GR.	Iron	11-13	glutathione-disulfide reductase	Homo sapiens	80-82
32692954-6	2020	Herein it is shown that bHLH121 is necessary for the expression of the main markers of the plant responses to Fe excess, the ferritin genes (i.e. FER1, FER3, and FER4).	Iron	110-112	ferritin 4	Arabidopsis thaliana	162-166
33739032-10	2021	Transferrin receptor helps in the internalization of iron in the cells.	Iron	53-57	transferrin receptor	Homo sapiens	0-20
32844323-2	2020	Although the HFE mutations that cause most cases of HH have been identified, their geographic distribution is highly variable, and their contribution to iron overload is not fully understood.	Iron	153-157	homeostatic iron regulator	Homo sapiens	13-16
32844323-4	2020	Donors with signs of iron overload at baseline and subsequent follow-up testing were recommended genotyping of the HFE gene.	Iron	21-25	homeostatic iron regulator	Homo sapiens	115-118
32844323-8	2020	Iron overload screening effectively detects individuals at risk of carrying the C282Y mutation of the HFE gene and enables early treatment to prevent HH complications.	Iron	0-4	homeostatic iron regulator	Homo sapiens	102-105
32107334-3	2021	Increased body iron content protects mice from anemia and, in basal conditions, Sv129/J Ncoa4-ko mice show only microcytosis; nevertheless, when fed a low-iron diet they develop a more severe anemia compared to wild-type animals.	Iron	15-19	nuclear receptor coactivator 4	Mus musculus	88-93
32502736-2	2020	1.5 at.% Fe-Cu bimetal on 1D sepiolite (Sep) (D-FeCu@Sep) with high dispersion and reduced chemical valence was prepared via complexation-carbonization process of glutathione.	Iron	9-11	membrane metalloendopeptidase like 1	Homo sapiens	40-43
32502736-2	2020	1.5 at.% Fe-Cu bimetal on 1D sepiolite (Sep) (D-FeCu@Sep) with high dispersion and reduced chemical valence was prepared via complexation-carbonization process of glutathione.	Iron	9-11	membrane metalloendopeptidase like 1	Homo sapiens	53-56
32822678-4	2020	Iron-loaded Tf (holoTf) in humans can support the proliferation of amoebae in vitro by binding to an amoebic TfR (EhTfR), and amoebae endocytose it inside clathrin-coated vesicles.	Iron	0-4	transferrin receptor	Homo sapiens	109-112
32107334-4	2021	Reciprocal bone marrow (BM) transplantation from wild-type donors into Ncoa4-ko and from Ncoa4-ko into wild-type mice revealed that microcytosis and susceptibility to iron deficiency anemia depend on BM-derived cells.	Iron	167-171	nuclear receptor coactivator 4	Mus musculus	89-94
32107334-7	2021	On the contrary, upon a low iron diet, spleen from wild-type animals with Ncoa4-ko BM displayed marked iron retention compared to (wild-type BM) controls, indicating defective macrophage iron release in the former.	Iron	28-32	nuclear receptor coactivator 4	Mus musculus	74-79
32107334-7	2021	On the contrary, upon a low iron diet, spleen from wild-type animals with Ncoa4-ko BM displayed marked iron retention compared to (wild-type BM) controls, indicating defective macrophage iron release in the former.	Iron	103-107	nuclear receptor coactivator 4	Mus musculus	74-79
32107334-7	2021	On the contrary, upon a low iron diet, spleen from wild-type animals with Ncoa4-ko BM displayed marked iron retention compared to (wild-type BM) controls, indicating defective macrophage iron release in the former.	Iron	103-107	nuclear receptor coactivator 4	Mus musculus	74-79
32107334-10	2021	Overall our data reveal a major role for NCOA4-mediated ferritinophagy in macrophages to favor iron release for erythropoiesis, especially in iron deficiency.	Iron	95-99	nuclear receptor coactivator 4	Mus musculus	41-46
32634119-8	2020	Furthermore, gene knockdown and deletion experiments performed in K562 cells, zebrafish, and mice demonstrate that loss of HSCB results in impaired Fe-S cluster biogenesis, a defect in RBC hemoglobinization, and the development of siderocytes and more broadly perturbs hematopoiesis in vivo.	Iron	148-152	HscB iron-sulfur cluster co-chaperone	Mus musculus	123-127
32895881-0	2021	The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder.	Iron	92-96	homeostatic iron regulator	Homo sapiens	35-38
31872339-6	2020	In animal experiments, we found that FeTmPyP, a representative ONOO- decomposition catalyst (PDC), significantly reduced the expression of HMGB1 and its receptor TLR2, and inhibited MMP-9 activation, preserved collagen IV and tight junction claudin-5 in ischemic rat brains with delayed t-PA treatment.	Iron	37-44	claudin 5	Rattus norvegicus	241-250
32895881-1	2021	The mutation of the homeostatic iron regulatory genes (HFE) impaired the hepatic hepcidin transcription leading to the chronic excess of the iron pool, with the adverse consequences of free radical oxidative damages.	Iron	32-36	homeostatic iron regulator	Homo sapiens	55-58
32895881-1	2021	The mutation of the homeostatic iron regulatory genes (HFE) impaired the hepatic hepcidin transcription leading to the chronic excess of the iron pool, with the adverse consequences of free radical oxidative damages.	Iron	141-145	homeostatic iron regulator	Homo sapiens	55-58
33469535-0	2020	Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis.	Iron	0-4	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	88-92
32895881-6	2021	These alterations also promoted the TfR-independent uptake of iron into other target tissues and left the TrF2/BMP-dependent-hepcidin activation pathway unattended.	Iron	62-66	transferrin receptor	Homo sapiens	36-39
33469535-0	2020	Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis.	Iron	102-106	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	88-92
33568304-3	2021	Previously, we have demonstrated the relationship between the PAP/SAL1 retrograde signaling pathway, the activity of Strategy I Fe uptake genes (FIT, FRO2, IRT1), and ethylene signaling.	Iron	128-130	ferric reduction oxidase 2	Arabidopsis thaliana	150-154
33469535-7	2020	Results: Iron overloaded mice exhibited greater cartilage destruction and elevated ADAMTS5 as well as MMP13 expression along with increased iron accumulation and dysregulated iron regulators.	Iron	9-13	matrix metallopeptidase 13	Mus musculus	102-107
33469535-8	2020	Pro-inflammatory cytokines could disturb cellular iron homeostasis via upregulating iron import proteins, TFR1 and DMT1, downregulating iron efflux protein FPN, thus result in cellular iron overload.	Iron	50-54	transferrin receptor	Mus musculus	106-110
33469535-8	2020	Pro-inflammatory cytokines could disturb cellular iron homeostasis via upregulating iron import proteins, TFR1 and DMT1, downregulating iron efflux protein FPN, thus result in cellular iron overload.	Iron	50-54	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	115-119
33469535-9	2020	Among iron transporters, DMT1 was found to play pivotal roles in iron overload induced OA progress.	Iron	6-10	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	25-29
33469535-9	2020	Among iron transporters, DMT1 was found to play pivotal roles in iron overload induced OA progress.	Iron	65-69	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	25-29
33469535-11	2020	Conclusions: Our results suggest that iron takes parts in the development of OA and cutting iron influx via inhibiting DMT1 activity could be an attractive new target for OA treatment.	Iron	38-42	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	119-123
33469535-11	2020	Conclusions: Our results suggest that iron takes parts in the development of OA and cutting iron influx via inhibiting DMT1 activity could be an attractive new target for OA treatment.	Iron	92-96	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	119-123
33214825-1	2020	Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that has been implicated in the pathological cell death associated with various disorders including neurodegenerative diseases (e.g., Friedreich"s ataxia (FRDA), Alzheimer"s disease, and Parkinson"s disease), stroke, and traumatic brain injury.	Iron	18-22	frataxin	Homo sapiens	229-233
32634425-2	2020	Ferroptosis is a newly discovered regulated cell death caused by the iron-dependent accumulation of lipid peroxidation, which can be prevented by glutathione peroxidase 4 (GPX4).	Iron	69-73	glutathione peroxidase 4	Rattus norvegicus	146-170
32634425-2	2020	Ferroptosis is a newly discovered regulated cell death caused by the iron-dependent accumulation of lipid peroxidation, which can be prevented by glutathione peroxidase 4 (GPX4).	Iron	69-73	glutathione peroxidase 4	Rattus norvegicus	172-176
32932999-7	2020	Hepatic caspase-3 cleavage increased in Cont-CCl4 group, which was suppressed in Fe-CCl4 group.	Iron	81-83	caspase 3	Rattus norvegicus	8-17
33427739-2	2021	In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males.	Iron	68-72	homeostatic iron regulator	Homo sapiens	38-41
33641078-2	2021	The iron-regulatory effect of furin, a ubiquitously expressed proconvertase, might play an important role in AD.	Iron	4-8	furin (paired basic amino acid cleaving enzyme)	Mus musculus	30-35
33427739-10	2021	CONCLUSION: Studies are needed of whether early iron reduction prevents or slows related brain pathologies in male HFE p.C282Y homozygotes.	Iron	48-52	homeostatic iron regulator	Homo sapiens	115-118
33433155-3	2021	Single nucleotide polymorphisms (SNPs) in the homeostatic iron regulator (HFE) gene have been shown to modify iron metabolism and can be used to predict an individual"s risk of hemochromatosis.	Iron	58-62	homeostatic iron regulator	Homo sapiens	74-77
33433155-3	2021	Single nucleotide polymorphisms (SNPs) in the homeostatic iron regulator (HFE) gene have been shown to modify iron metabolism and can be used to predict an individual"s risk of hemochromatosis.	Iron	110-114	homeostatic iron regulator	Homo sapiens	74-77
32730698-6	2020	We show that expression of the metal-ion transporter, Zip14, is markedly upregulated in cachectic muscles from these mice and is associated with elevated intramuscular zinc and iron levels.	Iron	177-181	solute carrier family 39 (zinc transporter), member 14	Mus musculus	54-59
33641078-3	2021	Therefore, there is an urgent need to study the effect of furin on iron regulation in AD.	Iron	67-71	furin (paired basic amino acid cleaving enzyme)	Mus musculus	58-63
32652260-0	2020	Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment.	Iron	0-4	Janus kinase 2	Homo sapiens	52-56
33641078-5	2021	Treadmill exercise attenuated the AD-related abnormal brain iron regulation by furin in vivo, as demonstrated via experiments in aged APP-C105 mice.	Iron	60-64	furin (paired basic amino acid cleaving enzyme)	Mus musculus	79-84
32652260-3	2020	In this study, we found that iron overload upregulated the inflammatory cytokine interleukin-6 (IL-6) expression to activate Janus Kinases 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling in triple negative breast cancer (TNBC) MDA-MB-231 cell lines, resulting in epithelial-mesenchymal transition (EMT) and cancer cell migration, but it had no effects on the estrogen receptor (ER)-positive breast cancer MCF-7 cells.	Iron	29-33	Janus kinase 2	Homo sapiens	193-197
32652260-4	2020	However, in the presence of exogenous IL-6, iron overload could also dramatically induce an autocrine IL-6 loop in ER-positive MCF-7 cells to active IL-6/JAK2/STAT3 signaling, resulting in enhanced EMT and cell motility.	Iron	44-48	Janus kinase 2	Homo sapiens	154-158
33641078-7	2021	We first observed that cognitive decline and Abeta-induced neuronal cell death were induced by disruption of APP processing via excess iron-induced disruption of furin activity in aged APP-C105 mice.	Iron	135-139	furin (paired basic amino acid cleaving enzyme)	Mus musculus	162-167
33122194-4	2020	Yeast two-hybrid and bimolecular fluorescence complementation studies demonstrated interaction of both the NFU4 and NFU5 proteins with the ISCA class of Fe-S carrier proteins.	Iron	153-157	NFU domain protein 5	Arabidopsis thaliana	116-120
33122194-5	2020	Recombinant NFU4 and NFU5 were purified as apo-proteins after expression in Escherichia coli In vitro Fe-S cluster reconstitution led to the insertion of one [4Fe-4S]2+ cluster per homodimer as determined by UV-visible absorption/CD, resonance Raman and EPR spectroscopy, and analytical studies.	Iron	102-106	NFU domain protein 5	Arabidopsis thaliana	21-25
33641078-9	2021	This result suggests that treadmill exercise alleviated cognitive decline and Abeta-induced neuronal cell death by promoting alpha-secretase-dependent processing of APP through low iron-induced enhancement of furin activity.	Iron	181-185	furin (paired basic amino acid cleaving enzyme)	Mus musculus	209-214
33596641-0	2021	A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria.	Iron	18-22	5'-aminolevulinate synthase 2	Homo sapiens	45-50
33392254-3	2020	Hemopexin both detoxifies heme to maintain iron homeostasis and bolsters antioxidant capacity via catabolic products, biliverdin and carbon monoxide to combat iron-mediated lipid peroxidation.	Iron	43-47	hemopexin	Homo sapiens	0-9
33392254-3	2020	Hemopexin both detoxifies heme to maintain iron homeostasis and bolsters antioxidant capacity via catabolic products, biliverdin and carbon monoxide to combat iron-mediated lipid peroxidation.	Iron	159-163	hemopexin	Homo sapiens	0-9
32825954-2	2020	The main mechanisms of virus internalization and interaction with the host are down-regulation or upregulation of the ACE2 receptor, the surface glycoprotein competition mechanism for the binding of porphyrin to iron in heme formation as well as interference with the immune system.	Iron	212-216	angiotensin converting enzyme 2	Homo sapiens	118-122
32863212-7	2020	Treating human macrophages with FAC, we observed a switch toward a M2-like phenotype associated with an increased expression of anti-inflammatory markers such as ARG1, suggesting the establishment of an iron-mediated immune suppressive tumor microenvironment favouring myeloma growth.	Iron	203-207	arginase 1	Homo sapiens	162-166
33596964-10	2021	Genetic testing showed that the patient was heterozygous for human homeostatic iron regulator protein (HFE) C282Y mutation and the normal allele.	Iron	79-83	homeostatic iron regulator	Homo sapiens	103-106
32863219-1	2020	Transferrin (Tf) is an essential serum protein which delivers iron throughout the body via transferrin-receptor (TfR)-mediated uptake and iron release in early endosomes.	Iron	62-66	transferrin receptor	Homo sapiens	91-111
32863219-1	2020	Transferrin (Tf) is an essential serum protein which delivers iron throughout the body via transferrin-receptor (TfR)-mediated uptake and iron release in early endosomes.	Iron	62-66	transferrin receptor	Homo sapiens	113-116
33609526-4	2021	Here, we used human kidney-derived HEK293 cells as a model, and we report that FLCN promotes the binding of Rab11A with transferrin receptor 1 (TfR1), which is required for iron uptake through continuous trafficking between the cell surface and the cytoplasm.	Iron	173-177	RAB11A, member RAS oncogene family	Homo sapiens	108-114
33348670-2	2020	Frataxin"s actual physiological function has been debated for a long time without reaching a general agreement; however, it is commonly accepted that the protein is involved in the biosynthetic iron-sulphur cluster (ISC) machinery, and several authors have pointed out that it also participates in iron homeostasis.	Iron	194-198	frataxin	Homo sapiens	0-8
32601061-6	2020	We observed a substrate-bound B-type dinitrosyl iron center complex in ADO, suggesting the possibility of dioxygen binding to the iron ion in a side-on mode.	Iron	48-52	2-aminoethanethiol (cysteamine) dioxygenase	Mus musculus	71-74
33609526-4	2021	Here, we used human kidney-derived HEK293 cells as a model, and we report that FLCN promotes the binding of Rab11A with transferrin receptor 1 (TfR1), which is required for iron uptake through continuous trafficking between the cell surface and the cytoplasm.	Iron	173-177	transferrin receptor	Homo sapiens	120-142
32601061-6	2020	We observed a substrate-bound B-type dinitrosyl iron center complex in ADO, suggesting the possibility of dioxygen binding to the iron ion in a side-on mode.	Iron	130-134	2-aminoethanethiol (cysteamine) dioxygenase	Mus musculus	71-74
33007541-7	2020	Lead imposition activated iron starvation pathway via elevation in methionine content and expression of iron uptake and hemostasis-related genes including Yellow Stripe1 (ZmYS 1), S-adenosylmethionine synthase (ZmSAMS) and 2"-deoxymugineic acid synthase (ZmDMAS1) in roots.	Iron	26-30	S-adenosylmethionine synthetase 1	Zea mays	180-209
33609526-4	2021	Here, we used human kidney-derived HEK293 cells as a model, and we report that FLCN promotes the binding of Rab11A with transferrin receptor 1 (TfR1), which is required for iron uptake through continuous trafficking between the cell surface and the cytoplasm.	Iron	173-177	transferrin receptor	Homo sapiens	144-148
33665641-7	2021	The intensified metabolism of activated lymphocytes requires the support of enhanced iron acquisition, which is facilitated by IRP1/2 and TFRC.	Iron	85-89	aconitase 1	Homo sapiens	127-133
33051205-1	2020	Heme oxygenase-2 (HO2) and -1 (HO1) catalyze heme degradation to biliverdin, CO, and iron, forming an essential link in the heme metabolism network.	Iron	85-89	heme oxygenase 2	Homo sapiens	0-16
33051205-1	2020	Heme oxygenase-2 (HO2) and -1 (HO1) catalyze heme degradation to biliverdin, CO, and iron, forming an essential link in the heme metabolism network.	Iron	85-89	heme oxygenase 2	Homo sapiens	18-21
32374849-5	2020	In addition, deleting hepatic Slc39a14 expression in Trf-LKO mice significantly reduced hepatic iron accumulation, thereby reducing ferroptosis-mediated liver fibrosis induced by either high dietary iron diet or CCl4 injections.	Iron	96-100	solute carrier family 39 (zinc transporter), member 14	Mus musculus	30-38
32374849-5	2020	In addition, deleting hepatic Slc39a14 expression in Trf-LKO mice significantly reduced hepatic iron accumulation, thereby reducing ferroptosis-mediated liver fibrosis induced by either high dietary iron diet or CCl4 injections.	Iron	199-203	solute carrier family 39 (zinc transporter), member 14	Mus musculus	30-38
32745684-1	2021	BACKGROUND & AIMS: Hemochromatosis that is associated with variants in the homeostatic iron regulator gene (HFE) is characterized by intestinal absorption of iron and excessive body and hepatic iron stores-it can lead to hepatic fibrosis and cirrhosis.	Iron	87-91	homeostatic iron regulator	Homo sapiens	108-111
33311482-3	2020	We find that either high-iron diets or Gpx4 depletion promotes 8-OHG release and thus activates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltration and activation during Kras-driven PDAC in mice.	Iron	25-29	stimulator of interferon response cGAMP interactor 1	Mus musculus	100-107
32745684-1	2021	BACKGROUND & AIMS: Hemochromatosis that is associated with variants in the homeostatic iron regulator gene (HFE) is characterized by intestinal absorption of iron and excessive body and hepatic iron stores-it can lead to hepatic fibrosis and cirrhosis.	Iron	158-162	homeostatic iron regulator	Homo sapiens	108-111
33311482-3	2020	We find that either high-iron diets or Gpx4 depletion promotes 8-OHG release and thus activates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltration and activation during Kras-driven PDAC in mice.	Iron	25-29	stimulator of interferon response cGAMP interactor 1	Mus musculus	108-113
33665641-7	2021	The intensified metabolism of activated lymphocytes requires the support of enhanced iron acquisition, which is facilitated by IRP1/2 and TFRC.	Iron	85-89	transferrin receptor	Homo sapiens	138-142
32745684-1	2021	BACKGROUND & AIMS: Hemochromatosis that is associated with variants in the homeostatic iron regulator gene (HFE) is characterized by intestinal absorption of iron and excessive body and hepatic iron stores-it can lead to hepatic fibrosis and cirrhosis.	Iron	158-162	homeostatic iron regulator	Homo sapiens	108-111
33659185-6	2021	The first and rate-limiting 5-aminolevulinate synthase 2 (ALAS2) enzyme controls heme synthesis and porphyrin production in erythroid cells, while iron availability modulates its expression through a post-transcriptional mechanism.	Iron	147-151	5'-aminolevulinate synthase 2	Homo sapiens	58-63
32629063-11	2020	Our findings reveal for the first time a role for pRb in heme and iron regulation, and demonstrate that pRb-induced anemia can be rescued in vivo through therapeutically enhancing PPAR signaling.	Iron	66-70	RB transcriptional corepressor 1	Homo sapiens	50-53
32737432-0	2020	IL-33: a key player in the development of iron-recycling red pulp macrophages.	Iron	42-46	interleukin 33	Homo sapiens	0-5
33628376-10	2021	The increase in nuclear translocation of metal-regulatory transcription factor 1 (MTF1) restored the function of FPN, abolished the intercellular iron overload, and protected cells against ferroptosis.	Iron	146-150	metal regulatory transcription factor 1	Homo sapiens	41-80
32584503-4	2020	In this study, we identified and demonstrated that GLU1, which encodes a ferredoxin-dependent glutamate synthase, was involved in iron homeostasis.	Iron	130-134	glutamate synthase 1	Arabidopsis thaliana	51-55
32584503-8	2020	Third, the product of GLU1, glutamate, could chelate iron in vivo and promote iron transportation.	Iron	53-57	glutamate synthase 1	Arabidopsis thaliana	22-26
32584503-8	2020	Third, the product of GLU1, glutamate, could chelate iron in vivo and promote iron transportation.	Iron	78-82	glutamate synthase 1	Arabidopsis thaliana	22-26
33628376-10	2021	The increase in nuclear translocation of metal-regulatory transcription factor 1 (MTF1) restored the function of FPN, abolished the intercellular iron overload, and protected cells against ferroptosis.	Iron	146-150	metal regulatory transcription factor 1	Homo sapiens	82-86
32584503-10	2020	Overall, our results provide evidence that GLU1 is involved in iron homeostasis through affecting glutamate synthesis under iron deficiency condition in Arabidopsis.	Iron	63-67	glutamate synthase 1	Arabidopsis thaliana	43-47
32540480-2	2020	The HFE (homeostatic iron regulator) gene variant (H63D) is highly prevalent in the population and has been investigated as a disease modifier in multiple neurodegenerative diseases.	Iron	21-25	homeostatic iron regulator	Homo sapiens	4-7
33180328-4	2021	TMPRSS6, a membrane serine protease expressed selectively in the liver, participates in regulating hepcidin production in response to iron stores by cleaving hemojuvelin (HJV).	Iron	134-138	transmembrane serine protease 6	Mus musculus	0-7
32793263-1	2020	The present work describes the effects on iron homeostasis when copper transport was deregulated in Arabidopsis thaliana by overexpressing high affinity copper transporters COPT1 and COPT3 (COPTOE ).	Iron	42-46	copper transporter 1	Arabidopsis thaliana	173-178
32793263-2	2020	A genome-wide analysis conducted on COPT1OE plants, highlighted that iron homeostasis gene expression was affected under both copper deficiency and excess.	Iron	69-73	copper transporter 1	Arabidopsis thaliana	36-41
32521439-0	2020	Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation.	Iron	47-51	solute carrier family 19 member 1	Rattus norvegicus	8-15
32521439-1	2020	The aim of this study was to determine how folate and iron deficiency, and the subsequent supplementation of rats" diet with these nutrients, affects Slc19a1and Tfr2 gene expression and the metabolism of folate and iron.	Iron	54-58	solute carrier family 19 member 1	Rattus norvegicus	150-157
33180328-5	2021	We have previously demonstrated that inhibiting TMPRSS6 expression with a hepatocyte-specific siRNA formulation, induces hepcidin, mitigates anemia, and reduces iron overload in murine models of beta-thalassemia intermedia and HH.	Iron	161-165	transmembrane serine protease 6	Mus musculus	48-55
32945551-1	2020	BACKGROUND: Hemochromatosis (HH) is characterized by chronic iron accumulation, leading to deleterious effects to various organ systems.	Iron	61-65	homeostatic iron regulator	Homo sapiens	12-27
32945551-1	2020	BACKGROUND: Hemochromatosis (HH) is characterized by chronic iron accumulation, leading to deleterious effects to various organ systems.	Iron	61-65	homeostatic iron regulator	Homo sapiens	29-31
32516526-9	2020	The results confirm recent proposals that ESP is an autonomous iron-dependent enzyme that intercepts the unstable aglycone rather than a direct effector of MYR.	Iron	63-67	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	42-45
33180328-6	2021	Here, we demonstrate that Tmprss6 siRNA treatment of double mutant Tfr2Y245X/Y245X HH Hbbth3/+ thalassemic mice induces hepcidin and diminishes tissue and serum iron levels.	Iron	161-165	transmembrane serine protease 6	Mus musculus	26-33
33180328-9	2021	These data indicate that siRNA suppression of Tmprss6, in conjunction with the targeting of TFR2, may be superior to inhibiting Tmprss6 alone in the treatment of the anemia and secondary iron loading in beta-thalassemia intermedia and may be useful as a method of suppressing the primary iron overload in TFR2-related (type 3) hereditary hemochromatosis.	Iron	187-191	transmembrane serine protease 6	Mus musculus	46-53
33098868-0	2020	miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.	Iron	96-100	microRNA 34a	Homo sapiens	0-7
32199885-7	2020	Furthermore, we propose that ferritin ferroxidase activity participates in the repair of the IRP1 [3Fe4S] cluster leading to the hypothesis that cytosolic ferritin directly contributes to cellular iron sensing.	Iron	197-201	Ferritin 1 heavy chain homologue	Drosophila melanogaster	29-37
33098868-10	2020	Silencing of miR-34a increased SIRT1 expression and alleviated triglyceride accumulation in the presence of OA and iron.	Iron	115-119	microRNA 34a	Homo sapiens	13-20
33180328-9	2021	These data indicate that siRNA suppression of Tmprss6, in conjunction with the targeting of TFR2, may be superior to inhibiting Tmprss6 alone in the treatment of the anemia and secondary iron loading in beta-thalassemia intermedia and may be useful as a method of suppressing the primary iron overload in TFR2-related (type 3) hereditary hemochromatosis.	Iron	288-292	transmembrane serine protease 6	Mus musculus	46-53
32199885-7	2020	Furthermore, we propose that ferritin ferroxidase activity participates in the repair of the IRP1 [3Fe4S] cluster leading to the hypothesis that cytosolic ferritin directly contributes to cellular iron sensing.	Iron	197-201	Ferritin 1 heavy chain homologue	Drosophila melanogaster	155-163
33096268-1	2021	BACKGROUND: Iron uptake mediated by transferrin receptor 1 (TfR1), encoded by the TFRC gene, is essential for lymphocyte development and proliferation.	Iron	12-16	transferrin receptor	Homo sapiens	36-58
32534701-14	2020	In addition, bioinformatics analysis indicated a positive correlation of SLC40A1 with hephaestin (HEPH), and homeostatic iron regulator (HFE).	Iron	121-125	homeostatic iron regulator	Homo sapiens	137-140
32846217-11	2020	NCOA4 could directly interact with ferritin and degrade it in a ferritinophagy-dependent manner, which subsequently released a great amount of iron.	Iron	143-147	nuclear receptor coactivator 4	Mus musculus	0-5
33096268-1	2021	BACKGROUND: Iron uptake mediated by transferrin receptor 1 (TfR1), encoded by the TFRC gene, is essential for lymphocyte development and proliferation.	Iron	12-16	transferrin receptor	Homo sapiens	60-64
33096268-1	2021	BACKGROUND: Iron uptake mediated by transferrin receptor 1 (TfR1), encoded by the TFRC gene, is essential for lymphocyte development and proliferation.	Iron	12-16	transferrin receptor	Homo sapiens	82-86
33175593-3	2020	Our goal was to determine the frequency of the two most common mutations in the coding region of the human iron homeostatic protein gene (HFE) in Europe: C282Y (rs1800562) and H63D (rs1799945) in WD patients, as well as to analyze their relation with WD phenotypic traits.	Iron	107-111	homeostatic iron regulator	Homo sapiens	138-141
33336851-0	2021	Iron accumulation regulates osteoblast apoptosis through lncRNA XIST/miR-758-3p/caspase 3 axis leading to osteoporosis.	Iron	0-4	microRNA 758	Mus musculus	69-76
32576829-6	2020	Here, we present structural and enzymological data showing that SAMHD1 utilises an active site, bi-metallic iron-magnesium centre that positions a hydroxide nucleophile in-line with the Palpha-O5" bond to catalyse phosphoester bond hydrolysis.	Iron	108-112	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	64-70
33941944-1	2021	Objective: The Aim of this study was to investigate the relationship of 3 common polymorphisms in the HFE gene (C282Y, H63D and S65C) with high body iron status in a population of Pakistani subjects with type 2 diabetes mellitus (DM) and to explore if there is any novel mutation in HFE gene in a sample of Pakistani subjects with type 2 DM.	Iron	149-153	homeostatic iron regulator	Homo sapiens	102-105
32652459-1	2020	Glyceronephosphate O-acyltransferase (GNPAT) p.D519G (rs11558492) was identified as a genetic modifier correlated with more severe iron overload in hemochromatosis through whole-exome sequencing of HFE p.C282Y homozygotes with extreme iron phenotypes.	Iron	131-135	homeostatic iron regulator	Homo sapiens	198-201
32652459-1	2020	Glyceronephosphate O-acyltransferase (GNPAT) p.D519G (rs11558492) was identified as a genetic modifier correlated with more severe iron overload in hemochromatosis through whole-exome sequencing of HFE p.C282Y homozygotes with extreme iron phenotypes.	Iron	235-239	homeostatic iron regulator	Homo sapiens	198-201
32652459-2	2020	We studied the prevalence of p.D519G in HFE p.C282Y/p.H63D compound heterozygotes, a genotype associated with iron overload in some patients.	Iron	110-114	homeostatic iron regulator	Homo sapiens	40-43
32625166-5	2020	Changes in serum iron parameters are common in adult NAFLD and have been termed dysmetabolic iron overload syndrome characterized by increased serum ferritin levels and normal transferrin saturation; however, the associations of serum ferritin, inflammation, and liver fat content have been incompletely investigated in children.	Iron	17-21	FAT atypical cadherin 1	Homo sapiens	269-272
33254954-1	2021	Porous silicate supported micro-nano zero-valent iron (PSi@ZVI) was prepared from copper slag (CS) through carbothermal reduction technology, and used as a persulfate (PS) activator for removing organic contaminants.	Iron	49-53	citrate synthase	Homo sapiens	95-97
32418850-3	2020	Our case suggests that in case of iron overload syndrome after liver transplantation we can perform a liver biopsy with real-time PCR technique that allows us to search for the mutation of the HFE.	Iron	34-38	homeostatic iron regulator	Homo sapiens	193-196
33004257-4	2021	In this review, we focus on the emerging role of GSNOR as a master regulator in oxidative stress through its regulation of the interaction of ROS, RNS, and Fe, and highlight recent discoveries in post-translational modifications of GSNOR and functional variations of natural GSNOR variants during oxidative stress.	Iron	156-158	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	49-54
32685207-0	2020	Factors Associated with the Nutritional Status among Male Workers of Iron and Steel Industries in Bara District, Nepal.	Iron	69-73	lin-9 DREAM MuvB core complex component	Homo sapiens	98-102
32685207-10	2020	Conclusions: The study has indicated that more than one-fourth of workers of iron and steel industries in Bara District of Nepal are overweight or obese.	Iron	77-81	lin-9 DREAM MuvB core complex component	Homo sapiens	106-110
32582297-2	2020	As a consequence, reduced levels of frataxin protein lead to mitochondrial iron accumulation, oxidative stress, and ultimately cell death; particularly in dorsal root ganglia (DRG) sensory neurons and the dentate nucleus of the cerebellum.	Iron	75-79	frataxin	Homo sapiens	36-44
32650195-3	2020	We show that the synergistic effect of Fe, N, B in the mesoporous carbon structure can derive excellent ORR activity, for which the FeNB/C-800 catalyst delivers an onset potential of 0.97 V (vs. reversible hydrogen electrode, RHE), a half-wave potential of 0.81 V (vs. RHE) and a high limiting current density (5.59 mA cm-2), comparable to a commercial Pt/C.	Iron	39-41	factor interacting with PAPOLA and CPSF1	Homo sapiens	226-229
32650195-3	2020	We show that the synergistic effect of Fe, N, B in the mesoporous carbon structure can derive excellent ORR activity, for which the FeNB/C-800 catalyst delivers an onset potential of 0.97 V (vs. reversible hydrogen electrode, RHE), a half-wave potential of 0.81 V (vs. RHE) and a high limiting current density (5.59 mA cm-2), comparable to a commercial Pt/C.	Iron	39-41	factor interacting with PAPOLA and CPSF1	Homo sapiens	269-272
33510144-4	2021	Mechanistically, NUPR1-mediated LCN2 expression blocks ferroptotic cell death through diminishing iron accumulation and subsequent oxidative damage.	Iron	98-102	lipocalin 2	Mus musculus	32-36
32901995-0	2020	First report of the spectrum of delta-globin gene mutations among women of reproductive age in Fujian area-Discrimination of delta-thalassemia, alpha-thalassemia, and Iron Deficiency Anemia.	Iron	167-171	hemoglobin subunit alpha 1	Homo sapiens	32-44
33121166-5	2020	The expression of matrix metalloproteinase (MMP)-2/-9 was markedly increased through iron treatment in 12Z cells.	Iron	85-89	matrix metallopeptidase 2	Homo sapiens	18-53
33121166-6	2020	Interestingly, intracellular reactive oxygen species (ROS) levels were significantly increased by iron in 12Z cells, and N-acetyl-L-cysteine significantly reduced iron-induced migration and MMP-2/-9 expression.	Iron	163-167	matrix metallopeptidase 2	Homo sapiens	190-198
33121166-7	2020	Additionally, iron stimulated the activation of the NFkappaB pathway, and the activation was associated with iron-induced migration and MMP-2/-9 expression in 12Z cells.	Iron	14-18	matrix metallopeptidase 2	Homo sapiens	136-144
33121166-7	2020	Additionally, iron stimulated the activation of the NFkappaB pathway, and the activation was associated with iron-induced migration and MMP-2/-9 expression in 12Z cells.	Iron	109-113	matrix metallopeptidase 2	Homo sapiens	136-144
32044627-1	2020	The nano zero-valent iron sludge-based biochar (nZVI-SBC) was prepared in this study to eliminate Sb(III) from aqueous solutions, which was characterized by BET, SEM, XRD, TEM, FTIR, XPS.	Iron	21-25	delta/notch like EGF repeat containing	Homo sapiens	157-160
32379419-6	2020	Our findings revealed that alpha-Syn affected brain iron homeostasis through modulating DMT1 protein stability and altering cellular iron uptake, which might uncover a direct evidence for the involvement of alpha-Syn in the iron metabolism dysfunction and provide insight into the further understanding of PD-associated nigral iron deposition.	Iron	52-56	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	88-92
33717488-7	2021	Genomic analysis identified selective sweeps in three genes; fecA, ptsP and ilvG unique to the iron (II) resistant populations, and gene expression studies demonstrated that their cellular response may be to downregulate genes involved in iron transport (cirA and fecA) while increasing the oxidative stress response (oxyR, soxS and soxR) prior to FeSO4 exposure.	Iron	95-99	phosphoenolpyruvate-protein phosphotransferase PtsP	Escherichia coli str. K-12 substr. MG1655	67-71
32368901-8	2020	The C93E CDO variant had similar overall structural properties as crosslinked CDO, but the iron was coordinated by a 3-His/1-Glu geometry leaving only two coordination sites available for dioxygen and bidentate L-cysteine binding.	Iron	91-95	viral integration site 1	Homo sapiens	119-124
33204330-0	2020	YTHDF1-enhanced iron metabolism depends on TFRC m6A methylation.	Iron	16-20	transferrin receptor	Homo sapiens	43-47
33204330-12	2020	Gain-of-function and loss-of-function analyses validated the finding showing that TFRC is a crucial target gene for YTHDF1-mediated increases in iron metabolism.	Iron	145-149	transferrin receptor	Homo sapiens	82-86
33204330-14	2020	From a therapeutic perspective, targeting YTHDF1 and TFRC-mediated iron metabolism may be a promising strategy for HPSCC.	Iron	67-71	transferrin receptor	Homo sapiens	53-57
33717488-11	2021	Lay summary: The evolution of iron resistance in E. coli leads to multi-drug and general metal resistance through the acquisition of mutations in three genes (fecA, ptsP and ilvG) while also initiating cellular defenses as part of their normal growth process.	Iron	30-34	phosphoenolpyruvate-protein phosphotransferase PtsP	Escherichia coli str. K-12 substr. MG1655	165-169
32351167-0	2020	Alteration of iron responsive gene expression in Arabidopsis glutaredoxin S17 loss of function plants with or without iron stress.	Iron	14-18	thioredoxin family protein	Arabidopsis thaliana	61-77
32351167-0	2020	Alteration of iron responsive gene expression in Arabidopsis glutaredoxin S17 loss of function plants with or without iron stress.	Iron	118-122	thioredoxin family protein	Arabidopsis thaliana	61-77
33435886-0	2021	Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin.	Iron	0-4	superoxide dismutase 2	Homo sapiens	68-72
32351167-5	2020	Heterologous expression of an Arabidopsis thaliana monothiol glutaredoxin S17 (GRXS17) suppresses the over-accumulation of iron in the Saccharomyces cerevisiae Grx3/Grx4 mutant and disruption of GRXS17 causes plant sensitivity to exogenous oxidants and iron deficiency stress.	Iron	123-127	thioredoxin family protein	Arabidopsis thaliana	61-77
32351167-5	2020	Heterologous expression of an Arabidopsis thaliana monothiol glutaredoxin S17 (GRXS17) suppresses the over-accumulation of iron in the Saccharomyces cerevisiae Grx3/Grx4 mutant and disruption of GRXS17 causes plant sensitivity to exogenous oxidants and iron deficiency stress.	Iron	123-127	thioredoxin family protein	Arabidopsis thaliana	79-85
32351167-5	2020	Heterologous expression of an Arabidopsis thaliana monothiol glutaredoxin S17 (GRXS17) suppresses the over-accumulation of iron in the Saccharomyces cerevisiae Grx3/Grx4 mutant and disruption of GRXS17 causes plant sensitivity to exogenous oxidants and iron deficiency stress.	Iron	123-127	thioredoxin family protein	Arabidopsis thaliana	195-201
32351167-6	2020	GRXS17 may act as an important regulator in the plant"s ability to respond to iron deficiency stress and maintain redox homeostasis.	Iron	78-82	thioredoxin family protein	Arabidopsis thaliana	0-6
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	ferric reduction oxidase 1	Arabidopsis thaliana	167-171
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	ferric reduction oxidase 2	Arabidopsis thaliana	177-181
33282461-5	2020	In this Perspective, we first explore what is known about the reactivity of heme-dependent cytochrome P450 oxygenases and nonheme iron-dependent oxygenases bearing the 2-His-1-carboxylate facial triad by reviewing mechanistic studies with an emphasis on how the protein scaffold maximizes the catalytic potential of the iron-heme and iron cofactors.	Iron	130-134	viral integration site 1	Homo sapiens	170-175
33282461-5	2020	In this Perspective, we first explore what is known about the reactivity of heme-dependent cytochrome P450 oxygenases and nonheme iron-dependent oxygenases bearing the 2-His-1-carboxylate facial triad by reviewing mechanistic studies with an emphasis on how the protein scaffold maximizes the catalytic potential of the iron-heme and iron cofactors.	Iron	320-324	viral integration site 1	Homo sapiens	170-175
33282461-5	2020	In this Perspective, we first explore what is known about the reactivity of heme-dependent cytochrome P450 oxygenases and nonheme iron-dependent oxygenases bearing the 2-His-1-carboxylate facial triad by reviewing mechanistic studies with an emphasis on how the protein scaffold maximizes the catalytic potential of the iron-heme and iron cofactors.	Iron	320-324	viral integration site 1	Homo sapiens	170-175
33065981-5	2020	Total kidney iron content was analyzed by Perls" staining, while Lcn-2-bound iron in the supernatants of short-term cultured cells was determined by atomic absorption spectroscopy.	Iron	77-81	lipocalin 2	Mus musculus	65-70
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	nicotianamine synthase 4	Arabidopsis thaliana	256-260
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	thioredoxin family protein	Arabidopsis thaliana	274-280
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	96-100	ferric reduction oxidase 1	Arabidopsis thaliana	167-171
32351167-8	2020	Our findings suggest that GRXS17 is required for tolerance to iron deficiency, and plays a negative regulatory role under conditions of iron sufficiency.	Iron	62-66	thioredoxin family protein	Arabidopsis thaliana	26-32
33065981-7	2020	In contrast, in renal MPhi Lcn-2 was low at 24 h, but increased at 48 h, where it mainly appeared in its iron-bound form.	Iron	105-109	lipocalin 2	Mus musculus	27-32
33065981-8	2020	Whereas TEC-secreted, iron-free Lcn-2 was associated with renal injury, increased MPhi-released iron-bound Lcn-2 was linked to renal recovery.	Iron	96-100	lipocalin 2	Mus musculus	107-112
33435886-7	2021	Iron loading decreased SIRT3 protein expression, promoted an increase in SOD2, and led to the elevation of mROS.	Iron	0-4	superoxide dismutase 2	Homo sapiens	73-77
33423253-3	2021	The excess of alpha-globin chains will form hemichromes which can damage red blood cell membranes and lead to hemolysis, ineffective erythropoiesis, and secondary iron overload.	Iron	163-167	hemoglobin subunit alpha 2	Homo sapiens	14-26
33053811-0	2020	The "Little Iron Waltz": The Ternary Response of Paracoccidioides spp.	Iron	12-16	histocompatibility minor 13	Homo sapiens	66-69
32248600-7	2020	Twist1, a transcriptional regulator of the epithelial-mesenchymal transition (EMT), has been shown to activate miR-199/214 transcription; thus, the expression level of Twist1 was examined in iron-induced and asbestos-induced mesotheliomas in rats.	Iron	191-195	twist family bHLH transcription factor 1	Rattus norvegicus	0-6
32248600-7	2020	Twist1, a transcriptional regulator of the epithelial-mesenchymal transition (EMT), has been shown to activate miR-199/214 transcription; thus, the expression level of Twist1 was examined in iron-induced and asbestos-induced mesotheliomas in rats.	Iron	191-195	twist family bHLH transcription factor 1	Rattus norvegicus	168-174
32248600-8	2020	Twist1 was exclusively expressed in iron saccharete-induced SMs but not in the epithelioid subtype.	Iron	36-40	twist family bHLH transcription factor 1	Rattus norvegicus	0-6
32248600-9	2020	The Twist1-miR-199/214 axis is activated in iron saccharate- and asbestos-induced SM.	Iron	44-48	twist family bHLH transcription factor 1	Rattus norvegicus	4-10
32470741-1	2020	When the nanoscale zero valent iron (nZVI) is used for the reduction of hexavalent chromium (Cr6+) to trivalent chromium (Cr3+) in groundwater, the reduction efficiency is decreased due to the passivation of reactive sites by precipitation.	Iron	31-35	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	122-125
33423253-6	2021	Subsequently, by manipulating the expression of key genes in iron metabolism such as hepcidin and transferrin receptor, researchers have revealed that iron restriction can improve ineffective hematopoiesis and iron overload, which may provide a potential approach for the treatment of thalassemia.	Iron	61-65	transferrin receptor	Homo sapiens	98-118
32470741-7	2020	Results show that Fe/Al BNPs and Al/Fe BNPs could reduce Cr6+ to Cr3+, and the removal efficiencies for Cr6+ were 1.47 g/g BNP and 0.07 g/g BNP, respectively.	Iron	18-20	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	65-68
33423253-6	2021	Subsequently, by manipulating the expression of key genes in iron metabolism such as hepcidin and transferrin receptor, researchers have revealed that iron restriction can improve ineffective hematopoiesis and iron overload, which may provide a potential approach for the treatment of thalassemia.	Iron	151-155	transferrin receptor	Homo sapiens	98-118
32107545-5	2020	The agb1 mutant altered metal ion profiles and exhibited severe growth arrest under zinc stress and aberrant root waving under iron and zinc stresses, while Galpha-null mutation attenuated leaf chlorosis under iron deficiency both in Arabidopsis and rice.	Iron	127-131	GTP binding protein beta 1	Arabidopsis thaliana	4-8
33423253-6	2021	Subsequently, by manipulating the expression of key genes in iron metabolism such as hepcidin and transferrin receptor, researchers have revealed that iron restriction can improve ineffective hematopoiesis and iron overload, which may provide a potential approach for the treatment of thalassemia.	Iron	151-155	transferrin receptor	Homo sapiens	98-118
32654761-5	2020	Although iron accumulation related to neurological diseases has been well documented, the pathoetiological contributions of the homeostatic iron regulator (HFE), which controls cellular iron uptake, is less understood.	Iron	140-144	homeostatic iron regulator	Homo sapiens	156-159
33419059-0	2021	Magnetospirillum magneticum as a Living Iron Chelator Induces TfR1 Upregulation and Decreases Cell Viability in Cancer Cells.	Iron	40-44	transferrin receptor	Homo sapiens	62-66
32654761-5	2020	Although iron accumulation related to neurological diseases has been well documented, the pathoetiological contributions of the homeostatic iron regulator (HFE), which controls cellular iron uptake, is less understood.	Iron	140-144	homeostatic iron regulator	Homo sapiens	156-159
32747755-5	2020	CD44 itself is transcriptionally regulated by nuclear iron through a positive feedback loop, which is in contrast to the negative regulation of the transferrin receptor by excess iron.	Iron	179-183	transferrin receptor	Homo sapiens	148-168
32826321-3	2020	GRXS17 is a nucleocytosolic monothiol glutaredoxin consisting of an N-terminal thioredoxin (TRX)-domain and three CGFS-active site motif-containing GRX-domains that coordinate three iron-sulfur (Fe-S) clusters in a glutathione (GSH)-dependent manner.	Iron	182-186	thioredoxin family protein	Arabidopsis thaliana	0-6
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	transferrin receptor	Homo sapiens	143-147
32621410-6	2020	Additional reports showed that miRNA can also modulate iron absorption, transport, storage and utilization via downregulation of DMT1, FPN, TFR1, TFR2, Ferritin H and other genes.	Iron	55-59	transferrin receptor	Homo sapiens	140-144
32621410-7	2020	It is noteworthy that some key epigenetic regulatory enzymes, such as DNA demethylase TET2 and histone lysine demethylase JmjC KDMs, require iron for the enzymatic activities.	Iron	141-145	tet methylcytosine dioxygenase 2	Homo sapiens	86-90
32429125-3	2020	Hereditary hemochromatosis (HH) is a potentially lethal disease leading to iron accumulation mostly due to mutations in the HFE gene.	Iron	75-79	homeostatic iron regulator	Homo sapiens	124-127
32826321-3	2020	GRXS17 is a nucleocytosolic monothiol glutaredoxin consisting of an N-terminal thioredoxin (TRX)-domain and three CGFS-active site motif-containing GRX-domains that coordinate three iron-sulfur (Fe-S) clusters in a glutathione (GSH)-dependent manner.	Iron	195-199	thioredoxin family protein	Arabidopsis thaliana	0-6
32826321-11	2020	We reveal the mechanism of an Fe-S cluster-dependent activity shift that converts the holoenzyme GRXS17 into a holdase, thereby preventing damage caused by heat stress.	Iron	30-34	thioredoxin family protein	Arabidopsis thaliana	97-103
32429125-4	2020	Indeed, homozygosity for the C282Y HFE mutation is associated with the primary iron overload phenotype.	Iron	79-83	homeostatic iron regulator	Homo sapiens	35-38
33157209-1	2021	Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and transferrin receptor 1 (TfR1) charges the cellular iron uptake.	Iron	144-148	transferrin receptor	Rattus norvegicus	93-115
33157209-1	2021	Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and transferrin receptor 1 (TfR1) charges the cellular iron uptake.	Iron	144-148	transferrin receptor	Rattus norvegicus	117-121
32707090-2	2020	Frataxin (FXN) is an essential protein that forms part of a supercomplex dedicated to the iron-sulfur (Fe-S) cluster assembly within the mitochondrial matrix.	Iron	103-107	frataxin	Homo sapiens	0-8
32404863-2	2020	Xeroderma pigmentosum group D (XPD), a DNA helicase involved in regulation of cell cycle and transcription, is a CIA target for iron-sulfur (Fe/S) modification.	Iron	141-143	Xeroderma pigmentosum D	Drosophila melanogaster	0-29
33098823-10	2021	Altogether, HSF1 may function as a key defender against PA-induced ferroptosis in cardiomyocytes by maintaining cellular iron homeostasis and GPX4 expression.	Iron	121-125	heat shock factor 1	Mus musculus	12-16
32404863-2	2020	Xeroderma pigmentosum group D (XPD), a DNA helicase involved in regulation of cell cycle and transcription, is a CIA target for iron-sulfur (Fe/S) modification.	Iron	141-143	Xeroderma pigmentosum D	Drosophila melanogaster	31-34
32707090-2	2020	Frataxin (FXN) is an essential protein that forms part of a supercomplex dedicated to the iron-sulfur (Fe-S) cluster assembly within the mitochondrial matrix.	Iron	103-107	frataxin	Homo sapiens	10-13
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	multiple C2 and transmembrane domain containing 2	Homo sapiens	270-275
32925401-0	2021	Association of HFE Gene Mutations With Serum Ferritin Level and Heart and Liver Iron Overload in Patients With Transfusion-dependent Beta-Thalassemia.	Iron	80-84	homeostatic iron regulator	Homo sapiens	15-18
33062942-0	2020	Control of Systemic Iron Homeostasis by the 3" Iron-Responsive Element of Divalent Metal Transporter 1 in Mice.	Iron	20-24	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	74-102
33062942-0	2020	Control of Systemic Iron Homeostasis by the 3" Iron-Responsive Element of Divalent Metal Transporter 1 in Mice.	Iron	47-51	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	74-102
32766655-10	2020	This raises the question as to the selective advantage of having two Tf, TfR-dependent routes of iron accumulation.	Iron	97-101	transferrin receptor	Homo sapiens	73-76
32971969-5	2020	Mice supplemented with Fe or EPA/DHA had lower soluble transferrin receptor, ferritin and hepcidin than controls, but these effects were attenuated in Fe+EPA/DHA mice.	Iron	23-25	transferrin receptor	Mus musculus	55-75
32611235-10	2020	Moreover erythrocyte iron and lipid abnormally colocalized in the same macrophages in Atf1-/- mice.	Iron	21-25	activating transcription factor 1	Mus musculus	86-90
32611235-11	2020	Therefore, iron-lipid separation was Atf1-dependent.	Iron	11-15	activating transcription factor 1	Mus musculus	37-41
32911833-6	2020	Also, we focus on the signalling pathways promoted by the transmembrane protein Neuropilin-1 (NRP1) in endothelial cells, its recently discovered role in regulating mitochondrial function and iron homeostasis and the role of mitochondrial dysfunction and iron in atherosclerosis and neurodegenerative diseases.	Iron	192-196	neuropilin 1	Homo sapiens	80-92
32911833-6	2020	Also, we focus on the signalling pathways promoted by the transmembrane protein Neuropilin-1 (NRP1) in endothelial cells, its recently discovered role in regulating mitochondrial function and iron homeostasis and the role of mitochondrial dysfunction and iron in atherosclerosis and neurodegenerative diseases.	Iron	192-196	neuropilin 1	Homo sapiens	94-98
32911833-6	2020	Also, we focus on the signalling pathways promoted by the transmembrane protein Neuropilin-1 (NRP1) in endothelial cells, its recently discovered role in regulating mitochondrial function and iron homeostasis and the role of mitochondrial dysfunction and iron in atherosclerosis and neurodegenerative diseases.	Iron	255-259	neuropilin 1	Homo sapiens	80-92
32917022-1	2020	In plants, the cysteine desulfurase (AtNFS1) and frataxin (AtFH) are involved in the formation of Fe-S groups in mitochondria, specifically, in Fe and sulfur loading onto scaffold proteins, and the subsequent formation of the mature Fe-S cluster.	Iron	98-100	frataxin-like protein	Arabidopsis thaliana	59-63
32917022-1	2020	In plants, the cysteine desulfurase (AtNFS1) and frataxin (AtFH) are involved in the formation of Fe-S groups in mitochondria, specifically, in Fe and sulfur loading onto scaffold proteins, and the subsequent formation of the mature Fe-S cluster.	Iron	144-146	frataxin-like protein	Arabidopsis thaliana	59-63
32917022-1	2020	In plants, the cysteine desulfurase (AtNFS1) and frataxin (AtFH) are involved in the formation of Fe-S groups in mitochondria, specifically, in Fe and sulfur loading onto scaffold proteins, and the subsequent formation of the mature Fe-S cluster.	Iron	144-146	frataxin-like protein	Arabidopsis thaliana	59-63
32917022-5	2020	Our results suggest that AtFH, AtNFS1 and AtISD11 form a multiprotein complex that could be involved in different stages of the iron-sulfur cluster (ISC) pathway in plant mitochondria.	Iron	128-132	frataxin-like protein	Arabidopsis thaliana	25-29
32911688-8	2020	Chronic TfRMAb dosing did not alter plasma- and brain-iron measurements, nor brain TfR levels, however, it significantly increased splenic-TfR and -iron.	Iron	148-152	transferrin receptor	Mus musculus	8-11
32607613-10	2020	SK4 derivatives that either lacked LAT1 affinity or had reduced iron chelation potency showed altered activity in our assay panel, as expected.	Iron	64-68	potassium calcium-activated channel subfamily N member 4	Homo sapiens	0-3
32565401-10	2020	The importance of these interactions is highlighted by the specific growth defect in iron-deficient conditions displayed by cells lacking Dhh1, Pop2, Ccr4 or Xrn1.	Iron	85-89	CCR4-NOT core exoribonuclease subunit CCR4	Saccharomyces cerevisiae S288C	150-154
32565401-10	2020	The importance of these interactions is highlighted by the specific growth defect in iron-deficient conditions displayed by cells lacking Dhh1, Pop2, Ccr4 or Xrn1.	Iron	85-89	chromatin-binding exonuclease XRN1	Saccharomyces cerevisiae S288C	158-162
32585319-1	2020	The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis.	Iron	152-156	bone morphogenetic protein 2	Homo sapiens	32-35
32585319-1	2020	The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis.	Iron	152-156	SMAD family member 1	Homo sapiens	37-41
32353809-6	2020	The result showed the BET surface area of Fe-Ni/AC, MWCNTs and MWCNTs-OCH2CO2H were obtained as 1100, 1250 and 1172 m2/g, respectively.	Iron	42-44	delta/notch like EGF repeat containing	Homo sapiens	22-25
32762549-1	2020	Aim: Two missense variants in the HFE gene, c.845G>A (p.Cys282Tyr) and c.187C>G (p.His63Asp), are commonly screened as part of the diagnostic workup for HFE-related hereditary hemochromatosis (HH) and iron overload.	Iron	201-205	homeostatic iron regulator	Homo sapiens	34-37
32762549-1	2020	Aim: Two missense variants in the HFE gene, c.845G>A (p.Cys282Tyr) and c.187C>G (p.His63Asp), are commonly screened as part of the diagnostic workup for HFE-related hereditary hemochromatosis (HH) and iron overload.	Iron	201-205	homeostatic iron regulator	Homo sapiens	153-156
32077535-0	2020	Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload.	Iron	113-117	solute carrier family 39 member 14	Rattus norvegicus	32-40
32574378-0	2020	H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity.	Iron	32-36	homeostatic iron regulator	Homo sapiens	48-51
32574378-3	2020	This study examines the effects of commonly occurring H63D variant of the homeostatic iron regulatory (HFE) gene on alpha-synuclein pathology in cell culture and animal models.	Iron	86-90	homeostatic iron regulator	Homo sapiens	103-106
32574378-9	2020	While iron chelator (deferiprone) treatment rescued WT HFE cells from pre-formed fibril toxicity, it exacerbated or was unable to rescue H63D HFE cells.	Iron	6-10	homeostatic iron regulator	Homo sapiens	55-58
32771565-6	2020	The exceptions were KIM-1 and NGAL, which showed later responses following CM and iron-induced renal injury.	Iron	82-86	lipocalin 2	Rattus norvegicus	30-34
32812355-6	2020	Different from previous reports, the polarization is ascribed to the fact that Fe3 O4 NPs mainly activate the IRF5 signaling pathway via iron ions instead of the reactive oxygen species-induced NF-kappaB signaling pathway.	Iron	137-141	interferon regulatory factor 5	Homo sapiens	110-114
32766721-0	2020	Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.	Iron	42-46	glyceronephosphate O-acyltransferase	Mus musculus	73-78
32766721-1	2020	Exome sequencing has identified the glyceronephosphate O-acyltransferase (GNPAT) gene as a genetic modifier of iron overload in hereditary hemochromatosis.	Iron	111-115	glyceronephosphate O-acyltransferase	Mus musculus	36-72
32766721-1	2020	Exome sequencing has identified the glyceronephosphate O-acyltransferase (GNPAT) gene as a genetic modifier of iron overload in hereditary hemochromatosis.	Iron	111-115	glyceronephosphate O-acyltransferase	Mus musculus	74-79
32766721-2	2020	Subjects with HFE (Homeostatic Iron Regulator) p.C282Y mutations and the GNPAT p.D519G variant had more iron loading compared to subjects without the GNPAT variant.	Iron	104-108	glyceronephosphate O-acyltransferase	Mus musculus	73-78
32766721-6	2020	We also examined the effect of dietary iron loading on mice with reduced Gnpat expression.	Iron	39-43	glyceronephosphate O-acyltransferase	Mus musculus	73-78
32833964-0	2020	An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells.	Iron	3-7	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	52-57
32833964-5	2020	Mechanistically, acute VPS34 inhibition enhanced lysosomal degradation of transferrin and low-density lipoprotein receptors leading to impaired iron and cholesterol uptake.	Iron	144-148	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	23-28
32833964-6	2020	Excess soluble iron, but not cholesterol, was sufficient to partially rescue the effects of VPS34 inhibition on mitochondrial respiration and cell growth, indicating that iron limitation is the primary driver of VPS34-dependency in RKO cells.	Iron	15-19	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	92-97
32833964-6	2020	Excess soluble iron, but not cholesterol, was sufficient to partially rescue the effects of VPS34 inhibition on mitochondrial respiration and cell growth, indicating that iron limitation is the primary driver of VPS34-dependency in RKO cells.	Iron	15-19	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	212-217
32833964-8	2020	Altogether, our findings suggest that impaired iron mobilization via the VPS34-RAB7A axis drive VPS34-dependence in certain cancer cells.	Iron	47-51	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	73-78
32833964-8	2020	Altogether, our findings suggest that impaired iron mobilization via the VPS34-RAB7A axis drive VPS34-dependence in certain cancer cells.	Iron	47-51	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	96-101
32817691-5	2020	This includes structural genes involved in Fe uptake (i.e. IRT1, FRO2, PDR9, NRAMP1) and transport (i.e. FRD3, NAS4) as well as a subset of their upstream regulators, namely BTS, PYE and the four clade Ib bHLH.	Iron	43-45	ferric reduction oxidase 2	Arabidopsis thaliana	65-69
32746697-2	2021	However, the in vivo physiological functions of the iron metabolism-related gene Hfe in immune response during viral infection remain poorly understood.	Iron	52-56	homeostatic iron regulator	Homo sapiens	81-84
32746697-3	2021	Here, we identified 5 iron metabolism-associated genes specifically affected during RNA virus infection by a high-throughput assay and further found that HFE was a key negative regulator of RIG-I-like receptors (RLR)-mediated type I interferons (IFNs) signaling.	Iron	22-26	homeostatic iron regulator	Homo sapiens	154-157
32746697-7	2021	These findings established a novel regulatory role of selective autophagy in innate antiviral immune response by the iron metabolism-related gene Hfe.	Iron	117-121	homeostatic iron regulator	Homo sapiens	146-149
32462051-1	2020	Friedreich"s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by expansion of GAA repeats in intron 1 of the frataxin (FXN) gene, leading to significant decreased expression of frataxin, a mitochondrial iron-binding protein.	Iron	228-232	frataxin	Homo sapiens	21-25
32462051-1	2020	Friedreich"s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by expansion of GAA repeats in intron 1 of the frataxin (FXN) gene, leading to significant decreased expression of frataxin, a mitochondrial iron-binding protein.	Iron	228-232	frataxin	Homo sapiens	134-142
32462051-1	2020	Friedreich"s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by expansion of GAA repeats in intron 1 of the frataxin (FXN) gene, leading to significant decreased expression of frataxin, a mitochondrial iron-binding protein.	Iron	228-232	frataxin	Homo sapiens	144-147
32462051-1	2020	Friedreich"s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by expansion of GAA repeats in intron 1 of the frataxin (FXN) gene, leading to significant decreased expression of frataxin, a mitochondrial iron-binding protein.	Iron	228-232	frataxin	Homo sapiens	202-210
32365611-6	2020	Lcn2 sequestered iron from infecting bacteria, particularly siderophore enterobactin-dependent members of the Enterobacteriaceae family, thereby limiting their proliferation.	Iron	17-21	lipocalin 2	Mus musculus	0-4
31751299-15	2020	With the dysregulation of iron-sulfur cluster formation ACO1 will convert to IRP1 which will decrease the 2-oxglutarate synthesis dysregulating the citric acid cycle and also dysregulating iron metabolism.	Iron	26-30	aconitase 1	Homo sapiens	56-60
31751299-15	2020	With the dysregulation of iron-sulfur cluster formation ACO1 will convert to IRP1 which will decrease the 2-oxglutarate synthesis dysregulating the citric acid cycle and also dysregulating iron metabolism.	Iron	26-30	aconitase 1	Homo sapiens	77-81
32380365-6	2020	Iron transportation-related gene, such as DMT1 and ZIP14, and ROS level were increased in iron overload-MDS-MSC (n = 23).	Iron	0-4	solute carrier family 39 member 14	Homo sapiens	51-56
32380365-6	2020	Iron transportation-related gene, such as DMT1 and ZIP14, and ROS level were increased in iron overload-MDS-MSC (n = 23).	Iron	90-94	solute carrier family 39 member 14	Homo sapiens	51-56
32341999-0	2020	Emergence of Ferrichelatase Activity in a Siderophore-Binding Protein Supports an Iron Shuttle in Bacteria.	Iron	82-86	selenium binding protein 1	Homo sapiens	42-69
32341999-2	2020	In Gram-positive bacteria, the currently accepted paradigm in siderophore-mediated iron acquisition is that effluxed metal-free siderophores extract ferric iron from biological sources and the resulting ferric siderophore complex undergoes diffusion-controlled association with a surface-displayed siderophore-binding protein (SBP) followed by ABC permease-mediated translocation across the cell envelope powered by ATP hydrolysis.	Iron	83-87	selenium binding protein 1	Homo sapiens	298-325
32341999-2	2020	In Gram-positive bacteria, the currently accepted paradigm in siderophore-mediated iron acquisition is that effluxed metal-free siderophores extract ferric iron from biological sources and the resulting ferric siderophore complex undergoes diffusion-controlled association with a surface-displayed siderophore-binding protein (SBP) followed by ABC permease-mediated translocation across the cell envelope powered by ATP hydrolysis.	Iron	83-87	selenium binding protein 1	Homo sapiens	327-330
32341999-5	2020	This new "iron shuttle" model closes a major knowledge gap in microbial iron acquisition and defines new roles of the siderophore and SBP as cofactor and enzyme, respectively, in addition to the classically accepted roles as a transport substrate and receptor pair.	Iron	10-14	selenium binding protein 1	Homo sapiens	134-137
32341999-5	2020	This new "iron shuttle" model closes a major knowledge gap in microbial iron acquisition and defines new roles of the siderophore and SBP as cofactor and enzyme, respectively, in addition to the classically accepted roles as a transport substrate and receptor pair.	Iron	72-76	selenium binding protein 1	Homo sapiens	134-137
31981661-2	2020	Prepared composite, [poly (Gg-AAm)/ZVI] was characterized by FESEM, TEM, BET, FTIR and XRD.	Iron	35-38	delta/notch like EGF repeat containing	Homo sapiens	73-76
32131593-3	2020	In the ISC pathway, the pyridoxal 5"-phosphate-dependent cysteine desulfurase enzyme IscS provides sulfur to the scaffold protein IscU, which templates the Fe-S cluster assembly.	Iron	156-160	NFS1 cysteine desulfurase	Homo sapiens	85-89
32109512-10	2020	In conclusion, minocycline and starch-desferal decrease mitochondrial dysfunction and severe liver injury after APAP overdose, suggesting that the MPT is likely triggered by iron uptake into mitochondria through MCU.	Iron	174-178	mitochondrial calcium uniporter	Mus musculus	212-215
32188787-0	2020	Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster.	Iron	0-4	Transferrin 1	Drosophila melanogaster	22-35
32188787-6	2020	Next, we show that the iron transporter Tsf1 is induced by infections downstream of the Toll and Imd pathways and is necessary for iron relocation from the hemolymph to the fat body.	Iron	23-27	Transferrin 1	Drosophila melanogaster	40-44
32188787-7	2020	Consistent with elevated iron levels in the hemolymph, Tsf1 mutants exhibited increased susceptibility to Pseudomonas bacteria and Mucorales fungi, which could be rescued by chemical chelation of iron.	Iron	25-29	Transferrin 1	Drosophila melanogaster	55-59
32188787-7	2020	Consistent with elevated iron levels in the hemolymph, Tsf1 mutants exhibited increased susceptibility to Pseudomonas bacteria and Mucorales fungi, which could be rescued by chemical chelation of iron.	Iron	196-200	Transferrin 1	Drosophila melanogaster	55-59
32115941-5	2020	As a result, the in situ-activated, Ni/Cr-doped Fe3O4 electrocatalyst exhibits an outstanding OER performance with a small overpotential of 262 mV to reach 10 mA cm-2, a low Tafel slope of 35.0 mV dec-1, and excellent long-term stability of 120 h, among the best spinel Fe-rich OER electrocatalysts.	Iron	48-50	deleted in esophageal cancer 1	Homo sapiens	197-202
32188161-2	2020	Lcn-2 possesses the ability to bind and transport iron with high affinity.	Iron	50-54	lipocalin 2	Mus musculus	0-5
32188161-3	2020	Therefore, the present study focuses on the decisive role of the Lcn-2 iron-load for its pro-regenerative function.	Iron	71-75	lipocalin 2	Mus musculus	65-70
32188161-6	2020	Their supernatants as well as recombinant iron-loaded holo-Lcn-2 was used for stimulation of Cisplatin-injured tubular epithelial cells.	Iron	42-46	lipocalin 2	Mus musculus	59-64
32188161-9	2020	Notably, we detected a positive correlation between total iron amounts in tubular epithelial cells and cellular proliferation, which, in turn, reinforced the assumed link between availability of Lcn-2-bound iron and recovery.	Iron	58-62	lipocalin 2	Mus musculus	195-200
32188161-9	2020	Notably, we detected a positive correlation between total iron amounts in tubular epithelial cells and cellular proliferation, which, in turn, reinforced the assumed link between availability of Lcn-2-bound iron and recovery.	Iron	207-211	lipocalin 2	Mus musculus	195-200
32188161-10	2020	We hypothesize that macrophage-released Lcn-2-bound iron is provided to tubular epithelial cells during toxic cell damage, whereby injury is limited and recovery is favored.	Iron	52-56	lipocalin 2	Mus musculus	40-45
31945692-4	2020	The mechanisms by which HK-2 protects cells is twofold, first by its ability to reduce oxidative stress generated by free radicals, and second, by its ability to complex biologically active transition metals such as Fe+2, thus reducing their availability to participate in the Fenton reaction where highly toxic hydroxyl radicals are generated.	Iron	216-220	hexokinase 2	Homo sapiens	24-28
32164753-12	2020	RESULTS: The associations of many biomarkers, such as several cytokines or the iron marker soluble transferrin receptor (sTfR), were similar in strength for T2D and CHD, but we also observed important differences.	Iron	79-83	transferrin receptor	Homo sapiens	99-119
32182331-12	2020	Conclusions: The above observations suggest that TGF-beta2 and hepcidin form a self-sustained feed-forward loop through iron-catalyzed ROS.	Iron	120-124	hepcidin antimicrobial peptide	Bos taurus	63-71
32182331-13	2020	This loop is partially disrupted by a hepcidin antagonist and an anti-oxidant, implicating iron and ROS in TGF-beta2-mediated POAG.	Iron	91-95	hepcidin antimicrobial peptide	Bos taurus	38-46
32156022-8	2020	Treatment of murine RAW 264.7 macrophages with nanoencapsulated DFO promoted an increased expression of transferrin receptor 1 (TfR1) mRNA, a typical homeostatic response to iron deficiency.	Iron	174-178	transferrin receptor	Mus musculus	128-132
32420530-3	2020	Here we examined mitophagy that is induced upon iron chelation and found that the transcriptional activity of HIF1alpha, in part through upregulation of BNIP3 and NIX, is an essential mediator of this pathway in SH-SY5Y cells.	Iron	48-52	BCL2 interacting protein 3 like	Homo sapiens	163-166
32180038-9	2020	In PC12 cells, a significant increase of transferrin receptor (TfR) mRNA expression was linked to Mn exposure and accompanied by elevated Fe uptake.	Iron	138-140	transferrin receptor	Rattus norvegicus	41-61
32180038-9	2020	In PC12 cells, a significant increase of transferrin receptor (TfR) mRNA expression was linked to Mn exposure and accompanied by elevated Fe uptake.	Iron	138-140	transferrin receptor	Rattus norvegicus	63-66
31816347-6	2020	The Fe-complex treatment caused cell cycle arrest via the activation of ATM-ATR kinase mediated DNA damage response pathway with the compromised expression of CDK1, CDK2 and CyclinB1 protein in Trigonella seedlings.	Iron	4-6	cyclin dependent kinase 2	Homo sapiens	165-169
32373202-4	2020	Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11).	Iron	27-31	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	252-259
32373202-8	2020	In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells.	Iron	106-110	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	169-176
31320750-12	2020	Genetic depletion of MTF-1 abolished the regulation of iron-regulatory elements by ATM and resensitized the cells to ferroptosis.	Iron	55-59	metal regulatory transcription factor 1	Homo sapiens	21-26
31320750-13	2020	Together, we have identified an unexpected ATM-MTF1-Ferritin/FPN1 regulatory axis as novel determinants of ferroptosis through regulating labile iron levels.	Iron	145-149	metal regulatory transcription factor 1	Homo sapiens	47-51
32004873-5	2020	The nPM lacks water-insoluble PAHs (polycyclic aromatic hydrocarbons) and is depleted by >50% in bioactive metals (e.g., copper, iron, nickel), inorganic ions, black carbon, and other organic compounds.	Iron	129-133	nucleophosmin 1	Homo sapiens	4-7
31744612-5	2020	Moreover, the (Fe/Ni)(P/S) nanorods showed a remarkable Tafel slope of 65.7 mV dec-1 with stable activity beyond two months with only 2.5% fluctuation.	Iron	15-17	deleted in esophageal cancer 1	Homo sapiens	79-84
32588509-7	2020	Benefiting from the structural and compositional advantages, the obtained Fe-doped Co3 O4 hierarchical NPs manifest superior electrocatalytic performance for OER with an overpotential of 262 mV at 10 mA cm-2 , a Tafel slope of 43 mV dec-1 , and excellent stability even at a high current density of 100 mA cm-2 for 50 h.	Iron	74-76	deleted in esophageal cancer 1	Homo sapiens	233-238
32251724-3	2020	In this study, we report that yeast cells lacking the transcription factor Mga2, which promotes the expression of the iron-dependent Delta9-fatty acid desaturase Ole1, display a defect in the activation of the iron regulon during the adaptation to iron limitation.	Iron	118-122	Mga2p	Saccharomyces cerevisiae S288C	75-79
32251724-3	2020	In this study, we report that yeast cells lacking the transcription factor Mga2, which promotes the expression of the iron-dependent Delta9-fatty acid desaturase Ole1, display a defect in the activation of the iron regulon during the adaptation to iron limitation.	Iron	210-214	Mga2p	Saccharomyces cerevisiae S288C	75-79
32251724-3	2020	In this study, we report that yeast cells lacking the transcription factor Mga2, which promotes the expression of the iron-dependent Delta9-fatty acid desaturase Ole1, display a defect in the activation of the iron regulon during the adaptation to iron limitation.	Iron	210-214	Mga2p	Saccharomyces cerevisiae S288C	75-79
31601687-0	2020	Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis.	Iron	32-36	transferrin receptor	Mus musculus	0-22
31601687-1	2020	Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis.	Iron	101-105	transferrin receptor	Mus musculus	0-22
31601687-1	2020	Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis.	Iron	101-105	transferrin receptor	Mus musculus	24-28
32925401-1	2021	OBJECTIVE: This study was performed on patients with transfusion-dependent beta-thalassemia (TDT) to investigate the effect of HFE gene mutations of iron overload in a large group of patients with TDT major and its relationship with heart and liver T2* magnetic resonance imaging (MRI) level.	Iron	149-153	homeostatic iron regulator	Homo sapiens	127-130
31601687-6	2020	Notably, hemin rescued the colony-forming capacity of Tfr1-deficient HSCs, whereas expressing a mutant Tfr1 that lack the protein"s iron-transporting capacity failed to rescue hematopoiesis.	Iron	132-136	transferrin receptor	Mus musculus	103-107
31601687-7	2020	These findings provide direct evidence that Tfr1 is essential for hematopoiesis through binding diferric transferrin to supply iron to cells.	Iron	127-131	transferrin receptor	Mus musculus	44-48
32925401-11	2021	Hence, it is recommended to consider HFE gene mutations among patients with thalassemia to reach a better iron overload evaluation and management.	Iron	106-110	homeostatic iron regulator	Homo sapiens	37-40
32586240-4	2021	AtOPT3 usually seemed to take part in Fe homeostasis whereas ZmOPT3 putatively interacted with proteins involved in various biological processes from plant defense system to stress responses.	Iron	38-40	oligopeptide transporter	Arabidopsis thaliana	0-6
31778583-6	2020	Notably, dietary iron loading still induced liver SMAD5 phosphorylation and hepcidin in double Bmp6/endothelial Bmp2 KO mice, although no other BMP ligand mRNAs were increased in the livers of double KO mice, and only Bmp6 and Bmp2 mRNA were induced by dietary iron loading in wildtype mice.	Iron	17-21	SMAD family member 5	Mus musculus	50-55
33457206-5	2021	The NFS1 gene encodes a cysteine desulfurase, which, in complex with ISD11 and ACP, initiates the first step of Fe-S formation.	Iron	112-116	NFS1 cysteine desulfurase	Homo sapiens	4-8
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	16-20	keratin 1	Homo sapiens	225-228
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	16-20	keratin 1	Homo sapiens	302-305
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	89-93	keratin 1	Homo sapiens	225-228
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	89-93	keratin 1	Homo sapiens	302-305
33457206-5	2021	The NFS1 gene encodes a cysteine desulfurase, which, in complex with ISD11 and ACP, initiates the first step of Fe-S formation.	Iron	112-116	CPAT1	Homo sapiens	79-82
33290455-1	2020	Stabilizing catalytic iron-oxo-clusters within nanoporous metal-organic frameworks (MOFs) is a powerful strategy to prepare new active materials for the degradation of toxic chemicals, such as bisphenol A. Herein, we combine pair distribution function analysis of total X-ray scattering data and X-ray absorption spectroscopy, with computational modelling to understand the local structural nature of added redox-active iron-oxo clusters bridging neighbouring zirconia-nodes within MOF-808.	Iron	22-26	lysine acetyltransferase 8	Homo sapiens	84-87
33363736-1	2020	beta-thalassemia heterozygosity can cause significant iron overload when accompanied by HFE gene mutations and inappropriate iron supplementation.	Iron	54-58	homeostatic iron regulator	Homo sapiens	88-91
32147528-6	2020	We demonstrate that Aft1 and the DNA-binding protein Ixr1 enhance the expression of the gene encoding for its catalytic subunit, RNR1, in response to iron limitation, leading to an increase in both mRNA and protein levels.	Iron	150-154	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	53-57
32147528-8	2020	Remarkably, Aft1 also activates the expression of IXR1 upon iron scarcity through an iron-responsive element located within its promoter.	Iron	60-64	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	50-54
32147528-8	2020	Remarkably, Aft1 also activates the expression of IXR1 upon iron scarcity through an iron-responsive element located within its promoter.	Iron	85-89	DNA-binding transcription repressor IXR1	Saccharomyces cerevisiae S288C	50-54
32596698-3	2020	The calcein fluorescence-quenching kinetics of polarized Caco-2 cells revealed the involvement of divalent transporter 1, macropinocytosis and nucleolin-mediated endocytosis in intestinal iron absorption from DNA-FeONPs with low molecular weight (<500 bp) favoring the performance of DNA in aiding iron absorption.	Iron	188-192	nucleolin	Homo sapiens	143-152
32129080-6	2020	The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2.	Iron	77-81	transferrin receptor	Mus musculus	26-30
32304229-2	2020	FDXR is the sole ferredoxin reductase in humans and plays a critical role in steroidogenesis and biosynthesis of heme and iron-sulfur clusters.	Iron	122-126	ferredoxin reductase	Homo sapiens	0-4
32304229-2	2020	FDXR is the sole ferredoxin reductase in humans and plays a critical role in steroidogenesis and biosynthesis of heme and iron-sulfur clusters.	Iron	122-126	ferredoxin reductase	Homo sapiens	17-37
32541839-0	2020	Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways.	Iron	0-4	CREB regulated transcription coactivator 1	Mus musculus	24-30
32541839-0	2020	Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways.	Iron	0-4	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	65-69
32541839-6	2020	Here, we found that iron chelators consistently inhibited mTORC1 signaling, which was blocked by pretreatment with ferrous sulfate.	Iron	20-24	CREB regulated transcription coactivator 1	Mus musculus	58-64
32541839-7	2020	Mechanistically, iron chelation-induced mTORC1 inhibition was not related to ROS induction, copper chelation, or PP2A activation.	Iron	17-21	CREB regulated transcription coactivator 1	Mus musculus	40-46
32541839-8	2020	Instead, activation of AMPK pathway mainly and activation of both HIF-1/REDD1 and Bnip3 pathways partially contribute to iron chelation-induced mTORC1 inhibition.	Iron	121-125	CREB regulated transcription coactivator 1	Mus musculus	144-150
32541839-9	2020	Our findings indicate that iron chelation inhibits mTORC1 via multiple pathways and iron is essential for mTORC1 activation.	Iron	27-31	CREB regulated transcription coactivator 1	Mus musculus	51-57
32541839-9	2020	Our findings indicate that iron chelation inhibits mTORC1 via multiple pathways and iron is essential for mTORC1 activation.	Iron	84-88	CREB regulated transcription coactivator 1	Mus musculus	106-112
32774262-1	2020	Primary hemochromatosis is an inherited disorder, and the homeostatic iron regulator (HFE) gene C282Y mutation is a common cause of hemochromatosis in Europe.	Iron	70-74	homeostatic iron regulator	Homo sapiens	86-89
32774262-2	2020	We are reporting a case of a 56-year-old female known to have hemochromatosis with the HFE gene C282Y mutation with a serum ferritin level of 482 mug/L who underwent heart and liver T2* MRI which showed no evidence of iron overload - neither in the heart nor in the liver.	Iron	218-222	homeostatic iron regulator	Homo sapiens	87-90
32202031-6	2020	These include NifS and NifU, found primarily in aerobic species, suggesting that these genes are necessary for accommodating the high demand for Fe-S clusters during aerobic nitrogen fixation.	Iron	145-149	NFS1 cysteine desulfurase	Homo sapiens	14-18
32058134-6	2020	BET test also indicated that ball-milled FeS2/Fe0 possessed a higher specific surface area than ball-milled Fe0.	Iron	41-43	delta/notch like EGF repeat containing	Homo sapiens	0-3
32058134-6	2020	BET test also indicated that ball-milled FeS2/Fe0 possessed a higher specific surface area than ball-milled Fe0.	Iron	46-49	delta/notch like EGF repeat containing	Homo sapiens	0-3
32681254-1	2020	Transferrin receptor 1 (TfR1), encoded by the TFRC gene, is the gatekeeper of cellular iron uptake for cells.	Iron	87-91	transferrin receptor	Homo sapiens	24-28
32681254-1	2020	Transferrin receptor 1 (TfR1), encoded by the TFRC gene, is the gatekeeper of cellular iron uptake for cells.	Iron	87-91	transferrin receptor	Homo sapiens	46-50
32681254-9	2020	These results together suggested that precisely controlled TfR1 expression might be not only essential for iron homeostasis, but also globally important for cell physiology, including ion transport and immunity.	Iron	107-111	transferrin receptor	Homo sapiens	59-63
32113105-5	2020	Further, the results indicated that dietary Fe exposure induced transient changes in the mRNA expression levels of various metal transporters, including the iron transporter dmt1, and the zinc transporters zip8 and zip14.	Iron	44-46	solute carrier family 11 member 2	Danio rerio	174-178
32460794-17	2020	CONCLUSION: Overall, this study established a novel mechanistic link between intracellular Ca2+ level, receptor-mediated TF trafficking, and iron homeostasis, all regulated by CAMKK2-CAMK4 signaling.	Iron	141-145	calcium/calmodulin dependent protein kinase IV	Homo sapiens	183-188
32456060-6	2020	The iron-enriched diet increased Hamp mRNA levels, as well as pSMAD1/5/8 and pSTAT3 protein levels, while no difference was observed in Hjv, Bmp6, Smad7, Tfr1, and Hfe mRNA levels and LIP compared to the CT group.	Iron	4-8	homeostatic iron regulator	Rattus norvegicus	164-167
32456060-7	2020	The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group.	Iron	45-49	homeostatic iron regulator	Rattus norvegicus	104-107
32456060-7	2020	The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group.	Iron	45-49	homeostatic iron regulator	Rattus norvegicus	209-212
32477344-6	2020	We examined if the iron chelator, desferrioxamine (DFX), could support the function of primary human macrophages infected with Mtb.	Iron	19-23	metallothionein 1J, pseudogene	Homo sapiens	127-130
32397086-7	2020	Additionally, hepcidin protein expression decreased in control and anemic animals fed fermented goat milk with normal iron content.	Iron	118-122	hepcidin antimicrobial peptide	Bos taurus	14-22
31377936-6	2020	In addition, compared to parenteral iron supplementation, greater serum IgA level, SOD, and GSH-Px activities, lower expressions of IL-1beta and TNF-alpha in the liver, and lower expressions of IL-6 and TNF-alpha in the spleen were found in oral iron piglets (P &lt; 0.05).	Iron	36-40	tumor necrosis factor	Sus scrofa	145-154
31377936-6	2020	In addition, compared to parenteral iron supplementation, greater serum IgA level, SOD, and GSH-Px activities, lower expressions of IL-1beta and TNF-alpha in the liver, and lower expressions of IL-6 and TNF-alpha in the spleen were found in oral iron piglets (P &lt; 0.05).	Iron	36-40	tumor necrosis factor	Sus scrofa	203-212
31392542-7	2020	Expression of Arn2, which is involved in iron uptake, was lower in MCHM-tolerant yeast and loss of Arn2 further increased MCHM tolerance.	Iron	41-45	siderophore transporter	Saccharomyces cerevisiae S288C	14-18
32172971-2	2020	In this study, an Fe-based metal-organic framework (MOF) (Materials of Institut Lavoisier: MIL-100 (Fe)) which was impregnated with reduced graphene oxide (rGO) by using a simple hydrothermal method and coated with birnessite-type manganese oxide (delta-MnO2) using the one-pot reaction process (MIL-100(Fe)/rGO/delta-MnO2 nanocomposites) was synthesized and applied successfully in As removal.	Iron	18-20	lysine acetyltransferase 8	Homo sapiens	27-56
32172971-2	2020	In this study, an Fe-based metal-organic framework (MOF) (Materials of Institut Lavoisier: MIL-100 (Fe)) which was impregnated with reduced graphene oxide (rGO) by using a simple hydrothermal method and coated with birnessite-type manganese oxide (delta-MnO2) using the one-pot reaction process (MIL-100(Fe)/rGO/delta-MnO2 nanocomposites) was synthesized and applied successfully in As removal.	Iron	100-102	lysine acetyltransferase 8	Homo sapiens	27-56
32172971-2	2020	In this study, an Fe-based metal-organic framework (MOF) (Materials of Institut Lavoisier: MIL-100 (Fe)) which was impregnated with reduced graphene oxide (rGO) by using a simple hydrothermal method and coated with birnessite-type manganese oxide (delta-MnO2) using the one-pot reaction process (MIL-100(Fe)/rGO/delta-MnO2 nanocomposites) was synthesized and applied successfully in As removal.	Iron	100-102	lysine acetyltransferase 8	Homo sapiens	27-56
31760327-3	2020	RESULTS: Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe.	Iron	39-43	CCAAT/enhancer binding protein zeta	Rattus norvegicus	125-129
32121405-0	2020	JNK/p66Shc/ITCH Signaling Pathway Mediates Angiotensin II-induced Ferritin Degradation and Labile Iron Pool Increase.	Iron	98-102	itchy E3 ubiquitin protein ligase	Bos taurus	11-15
32121405-4	2020	We hypothesized that Ang II-induced ferritin degradation and an increase in the labile iron pool are mediated by the c-Jun N-terminal kinase (JNK)/p66Shc/ITCH signaling pathway.	Iron	87-91	itchy E3 ubiquitin protein ligase	Bos taurus	154-158
32121405-10	2020	These observations suggest that Ang II-induced ferritin degradation and, hence, elevation of the levels of highly reactive iron, are mediated by the JNK/p66Shc/ITCH signaling pathway.	Iron	123-127	itchy E3 ubiquitin protein ligase	Bos taurus	160-164
32153640-1	2020	HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry.	Iron	55-59	homeostatic iron regulator	Homo sapiens	0-3
32642673-0	2020	Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma.	Iron	33-37	homeostatic iron regulator	Homo sapiens	55-58
32642673-6	2020	Therefore, we interrogated the expression of a key component of cellular iron regulation, the HFE (homeostatic iron regulatory) gene, on sexually dimorphic survival in GBM.	Iron	73-77	homeostatic iron regulator	Homo sapiens	94-97
32642673-6	2020	Therefore, we interrogated the expression of a key component of cellular iron regulation, the HFE (homeostatic iron regulatory) gene, on sexually dimorphic survival in GBM.	Iron	111-115	homeostatic iron regulator	Homo sapiens	94-97
31656209-0	2020	Simultaneous supplementation with iron and folic acid can affect Slc11a2 and Slc46a1 transcription and metabolite concentrations in rats.	Iron	34-38	solute carrier family 46 member 1	Rattus norvegicus	77-84
31896574-7	2020	We defined Aft1- and Yap1-dependent transcriptional sites in the MMT1 promoter that are necessary for low iron- or oxidant-mediated MMT1 expression.	Iron	106-110	Mmt1p	Saccharomyces cerevisiae S288C	65-69
31896574-7	2020	We defined Aft1- and Yap1-dependent transcriptional sites in the MMT1 promoter that are necessary for low iron- or oxidant-mediated MMT1 expression.	Iron	106-110	Mmt1p	Saccharomyces cerevisiae S288C	132-136
31896574-8	2020	We also found that the MMT2 promoter contains domains that are important for regulating its expression under low-iron conditions, including an upstream region that appears to partially repress expression under low-iron conditions.	Iron	113-117	Mmt2p	Saccharomyces cerevisiae S288C	23-27
31896574-8	2020	We also found that the MMT2 promoter contains domains that are important for regulating its expression under low-iron conditions, including an upstream region that appears to partially repress expression under low-iron conditions.	Iron	214-218	Mmt2p	Saccharomyces cerevisiae S288C	23-27
31896574-9	2020	Our findings reveal that both MMT1 and MMT2 are induced under low-iron conditions and that the low-iron regulator Aft1 is required for this induction.	Iron	66-70	Mmt1p	Saccharomyces cerevisiae S288C	30-34
31896574-9	2020	Our findings reveal that both MMT1 and MMT2 are induced under low-iron conditions and that the low-iron regulator Aft1 is required for this induction.	Iron	66-70	Mmt2p	Saccharomyces cerevisiae S288C	39-43
31896574-9	2020	Our findings reveal that both MMT1 and MMT2 are induced under low-iron conditions and that the low-iron regulator Aft1 is required for this induction.	Iron	99-103	Mmt1p	Saccharomyces cerevisiae S288C	30-34
31896574-10	2020	We further uncover an Aft1-binding site in the MMT1 promoter sufficient for inducing MMT1 transcription and identify an MMT2 promoter region required for low-iron induction.	Iron	158-162	Mmt2p	Saccharomyces cerevisiae S288C	120-124
32023254-8	2020	CONCLUSIONS/SIGNIFICANCE: In monocytes/macrophages of PKDL cases, enhancement of the iron influx gateways (TfR, CD163, DMT-1 and Lcn-2) possibly accounted for the enhanced LIP.	Iron	85-89	transferrin receptor	Homo sapiens	107-110
31661462-6	2020	With maternal iron deficiency, critical transporters mediating placental iron uptake (transferrin receptor 1 [TFR1]) and export (ferroportin [FPN]) were strongly regulated.	Iron	14-18	transferrin receptor	Mus musculus	86-108
31661462-6	2020	With maternal iron deficiency, critical transporters mediating placental iron uptake (transferrin receptor 1 [TFR1]) and export (ferroportin [FPN]) were strongly regulated.	Iron	14-18	transferrin receptor	Mus musculus	110-114
32296847-0	2020	Hippocampal Lipocalin 2 Is Associated With Neuroinflammation and Iron-Related Oxidative Stress in ob/ob Mice.	Iron	65-69	lipocalin 2	Mus musculus	12-23
32204069-2	2020	The current study was aimed to explore the impact of structural features of Sr/Fe co-doped hydroxyapatite (HAp) bionanomaterial on osteoblastic proliferation and osteogenic differentiation for its application as a bone substitute.	Iron	79-81	retinoic acid receptor, beta	Mus musculus	107-110
32204069-3	2020	A 10 mol% isomorphous co-doping of strontium and iron with respect to calcium was carried into HAp in the solid solution.	Iron	49-53	retinoic acid receptor, beta	Mus musculus	95-98
32204069-6	2020	TG/DTA analysis showed low thermal stability of the Sr/Fe co-doped HAp groups.	Iron	55-57	retinoic acid receptor, beta	Mus musculus	67-70
33290455-1	2020	Stabilizing catalytic iron-oxo-clusters within nanoporous metal-organic frameworks (MOFs) is a powerful strategy to prepare new active materials for the degradation of toxic chemicals, such as bisphenol A. Herein, we combine pair distribution function analysis of total X-ray scattering data and X-ray absorption spectroscopy, with computational modelling to understand the local structural nature of added redox-active iron-oxo clusters bridging neighbouring zirconia-nodes within MOF-808.	Iron	420-424	lysine acetyltransferase 8	Homo sapiens	84-87
33352721-4	2020	Iron delivery is mediated via transferrin internalization by the endocytosis of transferrin receptor type 1 (TFR1), one of the most abundant membrane proteins of erythroblasts.	Iron	0-4	transferrin receptor	Homo sapiens	80-107
32087552-2	2020	Rather than constrained to penta coordination, cytoglobin"s heme iron may exist either as a penta or hexacoordinated arrangement when exposed to different intracellular environments.	Iron	65-69	cytoglobin	Mus musculus	47-57
32099733-5	2020	The activities of caspase-3, caspase-8, and caspase-9 increased with increasing concentration of the nanoparticles indicating that activities of caspase can be activated by iron nanoparticles.	Iron	173-177	caspase 8	Homo sapiens	29-38
32099733-5	2020	The activities of caspase-3, caspase-8, and caspase-9 increased with increasing concentration of the nanoparticles indicating that activities of caspase can be activated by iron nanoparticles.	Iron	173-177	caspase 8	Homo sapiens	18-25
33352721-4	2020	Iron delivery is mediated via transferrin internalization by the endocytosis of transferrin receptor type 1 (TFR1), one of the most abundant membrane proteins of erythroblasts.	Iron	0-4	transferrin receptor	Homo sapiens	109-113
31724192-0	2020	Impact of natural neuromedin-B receptor variants on iron metabolism.	Iron	52-56	neuromedin B receptor	Homo sapiens	18-39
31724192-3	2020	Coding NMBR mutations were enriched in 129 patients with hereditary hemochromatosis or iron overload phenotype, as compared to ethnically matched controls, including 100 local healthy blood donors and 1000Genomes project participants (15.5% vs 5%, P = .0038 at burden test), and were associated with higher transferrin saturation in regular blood donors (P = .04).	Iron	87-91	neuromedin B receptor	Homo sapiens	7-11
32110797-1	2020	Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted low-molecular weight iron-siderophore binding protein.	Iron	85-89	lipocalin 2	Rattus norvegicus	0-42
33348670-4	2020	Using SDSL EPR and relating the results to fluorescence experiments commonly performed to study iron binding to FXN, we produced evidence that ferric iron causes reversible aggregation without preferred interfaces in a concentration-dependent fashion, starting at relatively low concentrations (micromolar range), whereas ferrous iron binds without inducing aggregation.	Iron	96-100	frataxin	Homo sapiens	112-115
32110797-1	2020	Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted low-molecular weight iron-siderophore binding protein.	Iron	85-89	lipocalin 2	Rattus norvegicus	44-48
31724192-6	2020	Furthermore, the circulating concentration of the natural NMBR ligand, Neuromedin-B, was reduced in response to iron challenge.	Iron	112-116	neuromedin B	Homo sapiens	71-83
31724192-10	2020	In conclusion, NMBR natural variants were enriched in patients with iron overload, and associated with facilitated iron absorption, possibly related to a defect of iron-induced hepcidin release.	Iron	68-72	neuromedin B receptor	Homo sapiens	15-19
33326952-1	2021	BACKGROUND: Hemochromatosis gene (HFE)-associated hereditary hemochromatosis (HH) is characterized by downregulation of hepcidin synthesis, leading to increased intestinal iron absorption.	Iron	172-176	homeostatic iron regulator	Homo sapiens	34-37
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	9-13	transferrin receptor	Rattus norvegicus	69-89
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	9-13	transferrin receptor	Rattus norvegicus	91-94
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	172-176	transferrin receptor	Rattus norvegicus	69-89
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	172-176	transferrin receptor	Rattus norvegicus	91-94
32976829-10	2020	Finally, ACSL4 inhibitor rosiglitazone (Rosi) was used in the development of DN, which improved survival rate and kidney function, reduced lipid peroxidation product MDA and iron content.	Iron	174-178	acyl-CoA synthetase long-chain family member 4	Mus musculus	9-14
32239172-13	2020	We conclude that iron/heme overload in HH increases xanthine oxidase activity and also promotes p53 degradation resulting in decreased ABCG2 expression.	Iron	17-21	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	135-140
32979804-10	2020	In addition, exposure to HEI (Con + Fe) incited hepatic oxidative stress based on an over-accumulation of malondialdehyde (MDA) along with a significant inhibition in superoxide dismutase (SOD) and catalase (CAT) activities; whereas in LVc + Fe and HVc + Fe, the MDA content restored to basal level.	Iron	36-38	catalase	Ictalurus punctatus	208-211
32346034-7	2020	Using RNA-seq analysis, we identified that an iron uptake-associated gene, transferrin receptor, was upregulated in obese ob/ob mice with LVH.	Iron	46-50	transferrin receptor	Mus musculus	75-95
32596110-6	2020	Notably, Tfr1 deficiency in interscapular brown adipose tissue (iBAT) leads to the transdifferentiation of brown preadipocytes into white adipocytes and muscle cells; in contrast, long-term exposure to a low-iron diet fails to phenocopy the transdifferentiation effect found in Tfr1-deficient mice.	Iron	208-212	transferrin receptor	Mus musculus	9-13
32596110-8	2020	Taken together, these findings indicate that Tfr1 plays an essential role in thermogenic adipocytes via both iron-dependent and iron-independent mechanisms.	Iron	109-113	transferrin receptor	Mus musculus	45-49
32596110-8	2020	Taken together, these findings indicate that Tfr1 plays an essential role in thermogenic adipocytes via both iron-dependent and iron-independent mechanisms.	Iron	128-132	transferrin receptor	Mus musculus	45-49
32909841-2	2020	At the cellular level, FRDA results in the deficiency of frataxin, a mitochondrial protein that plays a vital role in iron homeostasis and amelioration of oxidative stress.	Iron	118-122	frataxin	Homo sapiens	23-27
31923912-5	2020	Furthermore, comparing the experimental and calculated Seebeck coefficients and band-gap values of Fe2VAl, it implies that the GW methods including dynamically screened Coulomb interactions are more reliable than DFT with PBE or HSE06 functionals.	Iron	99-105	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	222-225
32909841-2	2020	At the cellular level, FRDA results in the deficiency of frataxin, a mitochondrial protein that plays a vital role in iron homeostasis and amelioration of oxidative stress.	Iron	118-122	frataxin	Homo sapiens	57-65
32165497-2	2020	The structure of the O2-reduction site of CcO contains two reducing equivalents, Fe a 3 2+ and CuB 1+, and suggests that a peroxide-bound state (Fe a 3 3+-O--O--CuB 2+) rather than an O2-bound state (Fe a 3 2+-O2) is the initial catalytic intermediate.	Iron	81-83	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	42-45
33405355-8	2020	In summary, a novel pathway was elucidated, showing that NAS1-dependent translocation of Fe from the root to the shoot is controlled by HAP5A in Fe-deficient Arabidopsis thaliana.	Iron	89-91	nicotianamine synthase 1	Arabidopsis thaliana	57-61
32165497-2	2020	The structure of the O2-reduction site of CcO contains two reducing equivalents, Fe a 3 2+ and CuB 1+, and suggests that a peroxide-bound state (Fe a 3 3+-O--O--CuB 2+) rather than an O2-bound state (Fe a 3 2+-O2) is the initial catalytic intermediate.	Iron	145-147	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	42-45
32165497-2	2020	The structure of the O2-reduction site of CcO contains two reducing equivalents, Fe a 3 2+ and CuB 1+, and suggests that a peroxide-bound state (Fe a 3 3+-O--O--CuB 2+) rather than an O2-bound state (Fe a 3 2+-O2) is the initial catalytic intermediate.	Iron	145-147	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	42-45
33405355-8	2020	In summary, a novel pathway was elucidated, showing that NAS1-dependent translocation of Fe from the root to the shoot is controlled by HAP5A in Fe-deficient Arabidopsis thaliana.	Iron	145-147	nicotianamine synthase 1	Arabidopsis thaliana	57-61
32763423-7	2020	We applied our new sorting strategy to demonstrate that CD71, which is the transferrin receptor mediating the uptake of transferrin-bound iron, is upregulated in beta-cells during early postnatal weeks.	Iron	138-142	transferrin receptor	Mus musculus	56-60
32327693-6	2020	The strong bidirectional effects seen in this study implicate ACO1, a known iron sensing molecule, as a major homeostatic regulator of hemoglobin concentration.	Iron	76-80	aconitase 1	Homo sapiens	62-66
32763423-7	2020	We applied our new sorting strategy to demonstrate that CD71, which is the transferrin receptor mediating the uptake of transferrin-bound iron, is upregulated in beta-cells during early postnatal weeks.	Iron	138-142	transferrin receptor	Mus musculus	75-95
32184317-4	2020	The airway tissue expression of the iron sequestration molecules divalent metal transporter 1 (DMT1) and transferrin receptor 1 (TFR1) are increased in asthma with TFR1 expression correlating with reduced lung function and increased type 2 (T2) inflammatory responses in the airways.	Iron	36-40	transferrin receptor	Homo sapiens	105-127
32763423-9	2020	In human beta-cells, CD71 is similarly required for iron-uptake and CD71 surface expression is regulated in a glucose-dependent manner.	Iron	52-56	transferrin receptor	Homo sapiens	21-25
32184317-4	2020	The airway tissue expression of the iron sequestration molecules divalent metal transporter 1 (DMT1) and transferrin receptor 1 (TFR1) are increased in asthma with TFR1 expression correlating with reduced lung function and increased type 2 (T2) inflammatory responses in the airways.	Iron	36-40	transferrin receptor	Homo sapiens	129-133
32184317-4	2020	The airway tissue expression of the iron sequestration molecules divalent metal transporter 1 (DMT1) and transferrin receptor 1 (TFR1) are increased in asthma with TFR1 expression correlating with reduced lung function and increased type 2 (T2) inflammatory responses in the airways.	Iron	36-40	transferrin receptor	Homo sapiens	164-168
32763423-10	2020	CONCLUSIONS: This study provides a novel and efficient purification method for murine alpha-, beta-, and delta-cells, identifies for the first time CD71 as a post-natal beta-cell-specific marker, and points to a central role for iron metabolism in beta-cell function.	Iron	229-233	transferrin receptor	Mus musculus	148-152
32184317-5	2020	Furthermore, pulmonary iron levels are increased in a house dust mite (HDM)-induced model of experimental asthma in association with augmented Tfr1 expression in airway tissue, similar to human disease.	Iron	23-27	transferrin receptor	Homo sapiens	143-147
33281618-0	2020	A Novel ALAS2 Missense Mutation in Two Brothers With Iron Overload and Associated Alterations in Serum Hepcidin/Erythroferrone Levels.	Iron	53-57	5'-aminolevulinate synthase 2	Homo sapiens	8-13
32331365-9	2020	Regarding iron metabolism biomarkers, serum soluble transferrin receptor (sTfR) was the strongest independent predictor of functional capacity (beta = -63, p < 0.0001, R2 0.39) and QoL (beta = 7.95, p < 0.0001, R2 0.14) in multivariate models.	Iron	10-14	transferrin receptor	Homo sapiens	52-72
32260496-10	2020	The correlations of serum hepcidin and erythroferrone with liver DMT1 and TfR represent significant mechanisms of Fe homeostasis.	Iron	114-116	transferrin receptor	Rattus norvegicus	74-77
32206507-11	2020	However, upregulation of ABCB7 increased the cytoplasm level of the iron-sulfur complex, which negatively regulated the iron-dependent protein and can be used to determine the progression of Parkinson"s disease.	Iron	68-72	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	25-30
32206507-11	2020	However, upregulation of ABCB7 increased the cytoplasm level of the iron-sulfur complex, which negatively regulated the iron-dependent protein and can be used to determine the progression of Parkinson"s disease.	Iron	120-124	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	25-30
31918395-0	2020	Mammalian iron-sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins.	Iron	10-14	dynein axonemal heavy chain 8	Homo sapiens	111-117
31714862-8	2020	Iron was higher in the hippocampus in GH rats compared to SI rats.	Iron	0-4	gamma-glutamyl hydrolase	Rattus norvegicus	38-40
31714862-10	2020	In serum, iron was higher in GH rats compared to SI rats.Conclusion: Emergence of schizophrenic-like symptoms is associated with the paradoxical concentration of iron in hippocampus and prefrontal cortex in the isolation period.	Iron	10-14	gamma-glutamyl hydrolase	Rattus norvegicus	29-31
31714862-10	2020	In serum, iron was higher in GH rats compared to SI rats.Conclusion: Emergence of schizophrenic-like symptoms is associated with the paradoxical concentration of iron in hippocampus and prefrontal cortex in the isolation period.	Iron	162-166	gamma-glutamyl hydrolase	Rattus norvegicus	29-31
32108988-1	2020	The GNPAT variant rs11558492 (p.D519G) was identified as a novel genetic factor that modifies the iron-overload phenotype in homozygous carriers of the HFE p.C282Y variant.	Iron	98-102	glyceronephosphate O-acyltransferase	Mus musculus	4-9
31967970-3	2020	Lipocalin-2 is an essential molecule which prevents bacterial infection by sequestering iron.	Iron	88-92	lipocalin 2	Mus musculus	0-11
32327961-3	2020	Furthermore, many HH patients are also afflicted by several immune defects and increased occurrence of autoimmune diseases that are linked to human homeostatic iron regulator protein (HFE) in the immune response.	Iron	160-164	homeostatic iron regulator	Homo sapiens	184-187
32205843-0	2020	Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus.	Iron	39-43	peroxiredoxin 5	Mus musculus	0-15
32205843-5	2020	Here, we demonstrate the role of peroxiredoxin 5 (Prx5) in iron overload-induced neurotoxicity using Prx5-deficient mice.	Iron	59-63	peroxiredoxin 5	Mus musculus	33-48
32205843-5	2020	Here, we demonstrate the role of peroxiredoxin 5 (Prx5) in iron overload-induced neurotoxicity using Prx5-deficient mice.	Iron	59-63	peroxiredoxin 5	Mus musculus	50-54
32205843-6	2020	Iron concentrations and ROS levels in mice fed a high iron diet were significantly higher in Prx5-/- mice than wildtype (WT) mice.	Iron	0-4	peroxiredoxin 5	Mus musculus	93-97
32205843-6	2020	Iron concentrations and ROS levels in mice fed a high iron diet were significantly higher in Prx5-/- mice than wildtype (WT) mice.	Iron	54-58	peroxiredoxin 5	Mus musculus	93-97
32205843-8	2020	Moreover, immunoreactive levels of cleaved caspase3 in the CA3 region of the hippocampus were higher in iron-loaded Prx5-/- mice than WT mice.	Iron	104-108	peroxiredoxin 5	Mus musculus	116-120
32205843-9	2020	Furthermore, treatment with N-acetyl-cysteine, a reactive oxygen species (ROS) scavenger, attenuated iron overload-induced hippocampal damage by inhibiting ROS production, ER-stress, and mitochondrial fission in iron-loaded Prx5-/- mice.	Iron	101-105	peroxiredoxin 5	Mus musculus	224-228
32205843-10	2020	Therefore, we suggest that iron overload-induced oxidative stress and ER-mediated mitochondrial fission may be essential for understanding iron-mediated neuronal cell death in the hippocampus and that Prx5 may be useful as a novel therapeutic target in the treatment of iron overload-mediated diseases and neurodegenerative diseases.	Iron	27-31	peroxiredoxin 5	Mus musculus	201-205
31270940-4	2020	The optimum Fe-doped NiCo-LDH OER catalyst showed a low overpotential of 285 mV at a current density of 10 mA cm-2 and a low Tafel slope of 62 mV dec-1 .	Iron	12-14	deleted in esophageal cancer 1	Homo sapiens	146-151
31874306-6	2020	The resulting Fe-Co/NPC displayed outstanding electrocatalytic activity for OER with appreciable onset potential (1.59 V (vs. RHE)), small Tafel slope (53.55 mV dec-1), low over-potential (396 mV) to reach 10 mA cm-2, and excellent durability with negligible loss in current density after 1000 cycles.	Iron	14-19	deleted in esophageal cancer 1	Homo sapiens	161-166
31865128-3	2020	The inside mechanism of the LFUA process includes: 1) displacement of HMIs from HMI-EDTA complexes by Fe(III); 2) direct photolysis of Fe(III)-EDTA through a ligand-to-metal charge transition reaction (LMCT) and indirect photolysis of EDTA by HO2 /O2 -.	Iron	102-109	heme oxygenase 2	Homo sapiens	243-246
31865128-5	2020	Fe(II) formed during the LMCT reaction of Fe(III)-EDTA was oxidized back to Fe(III) by O2 and HO2 , and the reformed Fe(III) was then recombined with EDTA to sustains the LMCT reaction.	Iron	0-6	heme oxygenase 2	Homo sapiens	94-97
31865128-5	2020	Fe(II) formed during the LMCT reaction of Fe(III)-EDTA was oxidized back to Fe(III) by O2 and HO2 , and the reformed Fe(III) was then recombined with EDTA to sustains the LMCT reaction.	Iron	42-49	heme oxygenase 2	Homo sapiens	94-97
31865128-5	2020	Fe(II) formed during the LMCT reaction of Fe(III)-EDTA was oxidized back to Fe(III) by O2 and HO2 , and the reformed Fe(III) was then recombined with EDTA to sustains the LMCT reaction.	Iron	76-83	heme oxygenase 2	Homo sapiens	94-97
32182331-3	2020	Smad4, an essential co-Smad, upregulates hepcidin, the master regulator of iron homeostasis.	Iron	75-79	SMAD family member 4	Homo sapiens	0-5
32182331-3	2020	Smad4, an essential co-Smad, upregulates hepcidin, the master regulator of iron homeostasis.	Iron	75-79	SMAD family member 4	Homo sapiens	0-4
32182331-8	2020	Hepcidin downregulates ferroportin, its downstream target, increasing ferritin and iron-catalyzed ROS.	Iron	83-87	hepcidin antimicrobial peptide	Bos taurus	0-8
32156022-8	2020	Treatment of murine RAW 264.7 macrophages with nanoencapsulated DFO promoted an increased expression of transferrin receptor 1 (TfR1) mRNA, a typical homeostatic response to iron deficiency.	Iron	174-178	transferrin receptor	Mus musculus	104-126
31705542-9	2020	CONCLUSION AND IMPLICATIONS: Losartan prevented the structural and functional indices of aortic stiffness in the iron loading rats, suggesting a capacity for renin-angiotensin system inhibition to limit the vascular remodeling in chronic iron overload.	Iron	238-242	renin	Rattus norvegicus	158-163
31642128-6	2020	We further show that AtNEET transfers its 2Fe-2S clusters to DRE2, a key protein of the cytosolic Fe-S biogenesis system, and propose that the availability of 2Fe-2S clusters in the chloroplast and cytosol is linked to iron homeostasis in plants.	Iron	219-223	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi	Arabidopsis thaliana	61-65
31600695-1	2020	Surface modified Cerium(IV)-incorporated hydrous Fe(III) oxide (CIHFO) with beta-cyclodextrin (beta-CD) nanocomposite (betaC-CIHFO) has been developed by in-situ wet chemical deposition method and characterized by means of some analytical tools such as FTIR, XRD,OM, SEM-EDX, TEM-EDX, AFM, TG-DTA and BET surface area analyses, resembled the irregular and undulated surface morphology consisting of microcrystals (~2-3 nm) and mesoporous (~6.022 nm) structure confirm surface amended CIHFO with beta-CD.	Iron	49-62	delta/notch like EGF repeat containing	Homo sapiens	301-304
31919822-1	2020	MIL-100(Fe), an environmental-friendly and water-stable metal-organic framework (MOF), has caught increasing research and application attention in the recent decade.	Iron	8-10	lysine acetyltransferase 8	Homo sapiens	56-85
31838906-3	2020	TfR1 (transferrin receptor 1) plays a crucial role in cellular iron transport.	Iron	63-67	transferrin receptor	Mus musculus	0-4
31838906-3	2020	TfR1 (transferrin receptor 1) plays a crucial role in cellular iron transport.	Iron	63-67	transferrin receptor	Mus musculus	6-28
31664701-7	2020	Results showed that iron given in the neonatal period impaired inhibitory avoidance memory and induced a decrease in proteins critically involved in the autophagy pathway, Beclin-1 and LC3, in the hippocampus.	Iron	20-24	beclin 1	Rattus norvegicus	172-180
31664701-7	2020	Results showed that iron given in the neonatal period impaired inhibitory avoidance memory and induced a decrease in proteins critically involved in the autophagy pathway, Beclin-1 and LC3, in the hippocampus.	Iron	20-24	annexin A3	Rattus norvegicus	185-188
31664701-8	2020	Rapamycin in the adulthood reversed iron-induced memory deficits, decreased the ratio phospho-mTOR/total mTOR, and recovered LC3 II levels in iron-treated rats.	Iron	142-146	annexin A3	Rattus norvegicus	125-128
31996219-6	2020	RESULTS: The results showed that there were statistically significant lower concentrations of erythrocyte Fe, Mg and P in MTG and HTG than CG.	Iron	106-108	serine protease 3	Homo sapiens	122-125
31854429-1	2020	A novel approach for the detection and separation of toxic ions was successfully developed via the introduction of competitive reactions into a long-alkyl-chained acylhydrazone-based coumarin supramolecular polymer, chemosensor OGC (3%, n-BuOH/H2O), which showed sequential detection and separation of CN-, Fe3+ and S2-, Ag+ in the gel state with high selectivity and sensitivity.	Iron	307-311	solute carrier family 25 member 11	Homo sapiens	228-231
32099899-7	2020	We demonstrate that TfR1 plays a crucial role for a rapid and transient activation of the ERK signaling pathway, which induces a deregulation of genes involved in the aberrant accumulation of intracellular free iron and in drug resistance.	Iron	211-215	transferrin receptor	Homo sapiens	20-24
31976154-0	2020	Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation.	Iron	26-34	PHD finger protein 8	Homo sapiens	55-59
31976154-4	2020	A PHF8 crystal structure manifests the 2OG C-1 carboxylate bound to iron in a nonproductive orientation, i.e., trans to His247.	Iron	68-72	PHD finger protein 8	Homo sapiens	2-6
31976154-11	2020	The overall mechanistic insights reveal the crucial role of iron-center rearrangement, second sphere interactions, and conformational flexibility in PHF8 catalysis and provide knowledge useful for the design of mechanism-based PHF8 inhibitors.	Iron	60-64	PHD finger protein 8	Homo sapiens	149-153
31976154-11	2020	The overall mechanistic insights reveal the crucial role of iron-center rearrangement, second sphere interactions, and conformational flexibility in PHF8 catalysis and provide knowledge useful for the design of mechanism-based PHF8 inhibitors.	Iron	60-64	PHD finger protein 8	Homo sapiens	227-231
31559819-7	2020	The incorporation of iron ions not only increased the gel modulus at 37  C from 107 to 680 Pa, but also promoted cell aggregation with a significant secretion of the cell adhesion signal of FAK.	Iron	21-25	protein tyrosine kinase 2	Homo sapiens	190-193
31559819-8	2020	Expression of biomarkers related to the neuronal differentiation of TMSCs, including NFM, MAP2, GFAP, NURR1, NSE, and TUBB3, increased 4-35-fold at the mRNA level in the Fe3+-containing system compared to that of the system without Fe3+.	Iron	170-174	tubulin beta 3 class III	Homo sapiens	118-123
31815328-4	2020	The Fe2 [(2,3,9,10,16,17,23,24-octahydroxy phthalocyaninato)Cu] MOF composited with I2 (Fe2 -O8 -PcCu/I2 ) serves as a cathode for a Na-I2 battery exhibiting a stable specific capacity of 150 mAh g-1 after 3200 cycles and outperforming the state-of-the-art cathodes for Na-I2 batteries.	Iron	4-7	lysine acetyltransferase 8	Homo sapiens	64-67
31815328-4	2020	The Fe2 [(2,3,9,10,16,17,23,24-octahydroxy phthalocyaninato)Cu] MOF composited with I2 (Fe2 -O8 -PcCu/I2 ) serves as a cathode for a Na-I2 battery exhibiting a stable specific capacity of 150 mAh g-1 after 3200 cycles and outperforming the state-of-the-art cathodes for Na-I2 batteries.	Iron	88-91	lysine acetyltransferase 8	Homo sapiens	64-67
31585922-3	2020	Some viruses selectively infect iron - acquiring cells or influence the cellular iron metabolism via Human hemochromatosis protein (HFE) or hepcidin.	Iron	81-85	homeostatic iron regulator	Homo sapiens	132-135
32042647-14	2020	Conclusion: These results suggest the potential for iron overload in hyperinsulinemic horses, a feature documented in other species and should stimulate further study into the relationship between insulin and iron dysregulation in the horse.	Iron	52-56	INS	Equus caballus	74-81
31730961-1	2020	In this work, a novel MOF(Fe)@NaAlg aerogels composite were fabricated by a facile method of ion cross-linking, and characterized via Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TG), X-ray photoelectron spectroscopy (XPS) and BET surface area analysis.	Iron	26-28	delta/notch like EGF repeat containing	Homo sapiens	320-323
32046303-1	2020	Iron-containing particulate catalysts of 0.1-1 microm size were prepared by wet and ball-milling procedures from common salts and characterized by FTIR, TGA, UV-Vis, PXRD, FEG-SEM, and XPS analyses.	Iron	0-4	T-box transcription factor 1	Homo sapiens	153-156
33167870-10	2020	Enrichment assessment revealed the biological processes that show the strongest association with RFI, RG and FE, i.e. digestive tract (salivary, gastric and mucin secretion) and metabolic processes (cellular and cardiovascular).	Iron	109-111	mucin 1, cell surface associated	Bos taurus	157-162
33263002-1	2020	Friedreich"s ataxia (FRDA) is a multi-faceted disease characterized by progressive sensory-motor loss, neurodegeneration, brain iron accumulation, and eventual death by hypertrophic cardiomyopathy.	Iron	128-132	frataxin	Homo sapiens	21-25
33263002-2	2020	FRDA follows loss of frataxin (FXN), a mitochondrial chaperone protein required for incorporation of iron into iron-sulfur cluster and heme precursors.	Iron	101-105	frataxin	Homo sapiens	0-4
33263002-2	2020	FRDA follows loss of frataxin (FXN), a mitochondrial chaperone protein required for incorporation of iron into iron-sulfur cluster and heme precursors.	Iron	101-105	frataxin	Homo sapiens	21-29
33263002-2	2020	FRDA follows loss of frataxin (FXN), a mitochondrial chaperone protein required for incorporation of iron into iron-sulfur cluster and heme precursors.	Iron	101-105	frataxin	Homo sapiens	31-34
33263002-2	2020	FRDA follows loss of frataxin (FXN), a mitochondrial chaperone protein required for incorporation of iron into iron-sulfur cluster and heme precursors.	Iron	111-115	frataxin	Homo sapiens	0-4
33263002-2	2020	FRDA follows loss of frataxin (FXN), a mitochondrial chaperone protein required for incorporation of iron into iron-sulfur cluster and heme precursors.	Iron	111-115	frataxin	Homo sapiens	21-29
33263002-2	2020	FRDA follows loss of frataxin (FXN), a mitochondrial chaperone protein required for incorporation of iron into iron-sulfur cluster and heme precursors.	Iron	111-115	frataxin	Homo sapiens	31-34
33263002-5	2020	Since then, the pathophysiology due to dysregulation of intracellular iron chaperoning has become central in FRDA relative to antioxidant defense and run-down in energy metabolism.	Iron	70-74	frataxin	Homo sapiens	109-113
33263002-10	2020	This review serves to outline a brief history of this research and hones in on pathway dysregulation downstream of iron-related pathology in FRDA related to actin dynamics.	Iron	115-119	frataxin	Homo sapiens	141-145
33263002-12	2020	The review examines previous hypotheses of neurodegeneration with brain iron accumulation (NBIA) in FRDA with a specific biochemical focus.	Iron	72-76	frataxin	Homo sapiens	100-104
33251209-3	2020	Methods: With a combination of RNA-sequencing of in vivo and in vitro models, we identified transferrin receptor (Tfr1), a receptor specialized for cellular iron uptake, as a previously unappreciated cell surface molecule for thermogenic adipocytes compared to white adipocytes.	Iron	157-161	transferrin receptor	Homo sapiens	92-112
33251209-3	2020	Methods: With a combination of RNA-sequencing of in vivo and in vitro models, we identified transferrin receptor (Tfr1), a receptor specialized for cellular iron uptake, as a previously unappreciated cell surface molecule for thermogenic adipocytes compared to white adipocytes.	Iron	157-161	transferrin receptor	Homo sapiens	114-118
32768850-5	2020	Moreover, our studies demonstrate that the combustions of toluene over Fe-based catalysts involve both the MvK and L-H mechanisms.	Iron	71-73	mevalonate kinase	Homo sapiens	107-110
33048522-1	2020	The mitochondrial outer membrane protein, mitoNEET (mNT), is an iron-sulfur protein containing an Fe2S2(His)1(Cys)3 cluster with a unique single Fe-N bond.	Iron	98-100	max binding protein	Mus musculus	52-55
33048522-3	2020	To further understand the effect of this unique Fe-N bond on the metal cluster and protein, we used atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS) to investigate the mechanical unfolding mechanism of an mNT monomer, focusing on the rupture pathway and kinetic stability of the cluster.	Iron	48-50	max binding protein	Mus musculus	232-235
33048522-5	2020	Moreover, this Fe-N bond enabled a dynamic and labile iron-sulfur cluster, as multiple unfolding pathways of mNT with a unique Fe2S2(Cys)3 intermediate were observed accordingly.	Iron	15-17	max binding protein	Mus musculus	109-112
33048522-5	2020	Moreover, this Fe-N bond enabled a dynamic and labile iron-sulfur cluster, as multiple unfolding pathways of mNT with a unique Fe2S2(Cys)3 intermediate were observed accordingly.	Iron	54-58	max binding protein	Mus musculus	109-112
32745723-3	2020	In eukaryotes, NEET proteins are localized to the mitochondria, endoplasmic reticulum (ER) and the mitochondrial-associated membranes connecting these organelles (MAM), and are involved in the control of multiple processes, ranging from autophagy and apoptosis to ferroptosis, oxidative stress, cell proliferation, redox control and iron and iron-sulfur homeostasis.	Iron	333-337	sarcoglycan gamma	Homo sapiens	163-166
32745723-3	2020	In eukaryotes, NEET proteins are localized to the mitochondria, endoplasmic reticulum (ER) and the mitochondrial-associated membranes connecting these organelles (MAM), and are involved in the control of multiple processes, ranging from autophagy and apoptosis to ferroptosis, oxidative stress, cell proliferation, redox control and iron and iron-sulfur homeostasis.	Iron	342-346	sarcoglycan gamma	Homo sapiens	163-166
32554019-3	2020	Grafting with Fe and Zr increased the zeta potential and zero point of charge (ZPC) of LF (from pH 3.9 to 7.4 for Fe grafting and to 7.6 for Zr grafting), due to chemical bonding of the metals, possibly with the hydroxyl and carboxylic groups in LF as indicated in FTIR peaks.	Iron	14-16	zona pellucida glycoprotein 3	Homo sapiens	79-82
32554019-3	2020	Grafting with Fe and Zr increased the zeta potential and zero point of charge (ZPC) of LF (from pH 3.9 to 7.4 for Fe grafting and to 7.6 for Zr grafting), due to chemical bonding of the metals, possibly with the hydroxyl and carboxylic groups in LF as indicated in FTIR peaks.	Iron	114-116	zona pellucida glycoprotein 3	Homo sapiens	79-82
32959428-0	2020	Phospholipase C beta1 (PI-PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron-induced oxidative stress in myelodysplastic syndromes (MDS).	Iron	103-107	phospholipase C beta 1	Homo sapiens	0-21
32959428-5	2020	At baseline, MDS patients showing a positive response after iron chelation therapy displayed higher levels of PI-PLCbeta1/Cyclin D3/PKCalpha expression.	Iron	60-64	phospholipase C beta 1	Homo sapiens	113-121
32959428-10	2020	All in all, our data show that PI-PLCbeta1 signaling is a target for iron-induced oxidative stress and suggest that baseline PI-PLCbeta1 quantification could predict iron chelation therapy response in MDS.	Iron	69-73	phospholipase C beta 1	Homo sapiens	34-42
32959428-10	2020	All in all, our data show that PI-PLCbeta1 signaling is a target for iron-induced oxidative stress and suggest that baseline PI-PLCbeta1 quantification could predict iron chelation therapy response in MDS.	Iron	166-170	phospholipase C beta 1	Homo sapiens	128-136
32739593-4	2020	Considering FA, which is due to the decreased expression of the mitochondrial protein, frataxin, this iron accumulation does not occur within protective storage proteins such as mitochondrial ferritin.	Iron	102-106	frataxin	Homo sapiens	87-95
32906022-7	2020	The FCR (ferric chelate reductase) activity in root along with the Fe concentration in root and shoot significantly increased, being consistent with the upregulation of Fe-related genes (SlNramp1 and SlFRO1) in roots.	Iron	169-171	ferric-chelate reductase	Solanum lycopersicum	4-7
32906022-7	2020	The FCR (ferric chelate reductase) activity in root along with the Fe concentration in root and shoot significantly increased, being consistent with the upregulation of Fe-related genes (SlNramp1 and SlFRO1) in roots.	Iron	169-171	ferric-chelate reductase	Solanum lycopersicum	9-33
32906022-7	2020	The FCR (ferric chelate reductase) activity in root along with the Fe concentration in root and shoot significantly increased, being consistent with the upregulation of Fe-related genes (SlNramp1 and SlFRO1) in roots.	Iron	169-171	ferric-chelate reductase	Solanum lycopersicum	200-206
33130561-0	2020	Preoperative iron treatment in anaemic patients undergoing elective total hip or knee arthroplasty: a systematic review and meta-analysis.	Iron	13-17	hedgehog interacting protein	Homo sapiens	74-77
33130561-2	2020	This meta-analysis aims to review the best available evidence on the clinical effectiveness of preoperative iron in anaemic patients undergoing elective total hip (THR) or total knee replacement (TKR).	Iron	108-112	hedgehog interacting protein	Homo sapiens	159-162
32029499-5	2020	We aim to conduct a three-arm randomised controlled trial to determine the effect of weekly folic acid with iron on erythrocyte folate, a biomarker of NTD risk.	Iron	108-112	fuzzy planar cell polarity protein	Homo sapiens	151-154
33178287-2	2020	The higher incidence of ASXL1 and TET2 gene mutations in our iron overload (IO) MDS patients suggests that IO may be involved in the pathogenesis of MDS.	Iron	61-65	tet methylcytosine dioxygenase 2	Homo sapiens	34-38
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	32-36	lysine acetyltransferase 8	Homo sapiens	62-65
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	32-36	lysine acetyltransferase 8	Homo sapiens	135-138
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	32-34	lysine acetyltransferase 8	Homo sapiens	62-65
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	32-34	lysine acetyltransferase 8	Homo sapiens	135-138
33126466-2	2020	FRDA is caused by reduced levels of frataxin (FXN), a mitochondrial protein involved in the synthesis of iron-sulphur clusters, leading to iron accumulation at the mitochondrial level, uncontrolled production of reactive oxygen species and lipid peroxidation.	Iron	105-109	frataxin	Homo sapiens	0-4
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	85-87	lysine acetyltransferase 8	Homo sapiens	62-65
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	85-87	lysine acetyltransferase 8	Homo sapiens	135-138
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	85-87	lysine acetyltransferase 8	Homo sapiens	62-65
31957979-3	2020	The in situ ion substitution of Fe3+ in a nitrogen-containing MOF (ZIF-8) allows the Fe-heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe-doped ZIF-8 nano-crystals with graphene-oxide and in situ reduction of graphene-oxide afford a sandwiched-like Fe-doped ZIF-8/graphene heterostructure.	Iron	85-87	lysine acetyltransferase 8	Homo sapiens	135-138
31724192-10	2020	In conclusion, NMBR natural variants were enriched in patients with iron overload, and associated with facilitated iron absorption, possibly related to a defect of iron-induced hepcidin release.	Iron	115-119	neuromedin B receptor	Homo sapiens	15-19
31724192-10	2020	In conclusion, NMBR natural variants were enriched in patients with iron overload, and associated with facilitated iron absorption, possibly related to a defect of iron-induced hepcidin release.	Iron	115-119	neuromedin B receptor	Homo sapiens	15-19
31776233-0	2020	The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.	Iron	100-104	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	48-55
31776233-0	2020	The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.	Iron	100-104	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	57-61
31776233-3	2020	In Arabidopsis (Arabidopsis thaliana), the transcription factor ILR3 plays a central role in controlling Fe homeostasis.	Iron	105-107	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	64-68
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	138-145
32019240-2	2020	In most cases, GAA trinucleotide repetitions in the first intron of the FXN gene are the genetic trigger of FA, determining a strong reduction of frataxin, a mitochondrial protein involved in iron homeostasis.	Iron	192-196	frataxin	Homo sapiens	72-75
32019240-2	2020	In most cases, GAA trinucleotide repetitions in the first intron of the FXN gene are the genetic trigger of FA, determining a strong reduction of frataxin, a mitochondrial protein involved in iron homeostasis.	Iron	192-196	frataxin	Homo sapiens	146-154
32019240-3	2020	Frataxin depletion impairs iron-sulfur cluster biosynthesis and determines iron accumulation in the mitochondria.	Iron	27-31	frataxin	Homo sapiens	0-8
31993836-2	2020	Here, we propose a facile and effective strategy to design a mesopore-structured Fe/N/C catalyst for the ORR with ultrahigh BET surface area and outstanding conductivity via nanochannels of molecular sieve-confined pyrolysis of Fe2+ ions coordinated with 2,4,6-tri(2-pyridyl)-1,3,5-triazine complexes as a novel precursor with the stable coordination effect.	Iron	81-83	delta/notch like EGF repeat containing	Homo sapiens	124-127
31993836-2	2020	Here, we propose a facile and effective strategy to design a mesopore-structured Fe/N/C catalyst for the ORR with ultrahigh BET surface area and outstanding conductivity via nanochannels of molecular sieve-confined pyrolysis of Fe2+ ions coordinated with 2,4,6-tri(2-pyridyl)-1,3,5-triazine complexes as a novel precursor with the stable coordination effect.	Iron	228-232	delta/notch like EGF repeat containing	Homo sapiens	124-127
31887022-0	2020	Monitoring Fe(II) Spin-State Equilibria via Eu(III) Luminescence in Molecular Complexes: Dream or Reality?	Iron	11-17	potassium voltage-gated channel interacting protein 3	Homo sapiens	89-94
31903507-2	2020	The Fe-MOF was prepared by one-step hydrothermalf method using 2-aminoterephthalic acid and iron(III) chloride.	Iron	92-110	lysine acetyltransferase 8	Homo sapiens	7-10
31740582-4	2020	We noted that these genes are involved in the synthesis of glutathione or metabolism of intracellular labile iron and include glutamate-cysteine ligase modifier subunit (Gclm), solute carrier family 7 member 11 (Slc7a11), ferritin heavy chain 1 (Fth1), ferritin light chain 1 (Ftl1), and solute carrier family 40 member 1 (Slc40a1).	Iron	109-113	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	212-219
32064157-3	2020	TFRC is an important participant in intracellular iron transport, and we noticed that it was abnormally overexpressed in EOC; however, its specific role in EOC remained unclear.	Iron	50-54	transferrin receptor	Homo sapiens	0-4
31854120-2	2020	Most patients are homozygous for expanded GAA triplet repeats in the first intron of the frataxin (FXN) gene, involved in mitochondrial iron metabolism.	Iron	136-140	frataxin	Homo sapiens	89-97
31854120-2	2020	Most patients are homozygous for expanded GAA triplet repeats in the first intron of the frataxin (FXN) gene, involved in mitochondrial iron metabolism.	Iron	136-140	frataxin	Homo sapiens	99-102
31343823-1	2020	BACKGROUND: The mitochondrial protein frataxin is involved in iron metabolism, as well as regulation of oxidative stress.	Iron	62-66	frataxin	Homo sapiens	38-46
31343823-7	2020	It was also demonstrated that T2D patients with frataxin mRNA levels in the lowest quartile had significantly elevated levels of serum iron, TOS, and inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6, while TAC levels were significantly lower in this quartile when compared with the upper quartile.	Iron	135-139	frataxin	Homo sapiens	48-56
31705350-2	2020	Data on the effect of alpha globin gene variation on the concentration of iron on transfusion dependent Saudis are scanty.	Iron	74-78	hemoglobin subunit alpha 2	Homo sapiens	22-34
31705350-3	2020	A total of 166 transfusions dependent beta-thalassemia were included in this study to understand association between the alpha globin gene variation and concentration of iron.	Iron	170-174	hemoglobin subunit alpha 2	Homo sapiens	121-133
31705350-6	2020	Saudi transfusion dependent female beta-thalassemia patients with wild alpha globin genotype (alphaalpha/alphaalpha) were observed with iron level beyond the normal range.	Iron	136-140	hemoglobin subunit alpha 2	Homo sapiens	71-83
32050136-9	2020	They substantiate that TCS+ is an indicator of iron accumulation in Parkinson"s disease within and in the vicinity of the SN.	Iron	47-51	treacle ribosome biogenesis factor 1	Homo sapiens	23-26
33211914-13	2020	In the liver, DAT knockout led to an increase in the content of As, Cd, Co, and Cs and a decrease in Fe; in the kidneys - to an increase in the levels of Pb, As, Cd and Se, in the brain - an increase in the content of most of the studied trace elements, including Pb, As, Cs, Al and Cu.	Iron	101-103	solute carrier family 6 member 3	Rattus norvegicus	14-17
31873120-0	2019	Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.	Iron	48-52	sideroflexin 4	Homo sapiens	0-14
31873120-6	2019	SFXN4 knockdown reduces the stability and activity of cellular Fe-S proteins, affects iron metabolism by influencing the cytosolic aconitase-IRP1 switch, redistributes iron from the cytosol to mitochondria, and impacts heme synthesis by reducing levels of ferrochelatase and inhibiting translation of ALAS2.	Iron	86-90	sideroflexin 4	Homo sapiens	0-5
31873120-6	2019	SFXN4 knockdown reduces the stability and activity of cellular Fe-S proteins, affects iron metabolism by influencing the cytosolic aconitase-IRP1 switch, redistributes iron from the cytosol to mitochondria, and impacts heme synthesis by reducing levels of ferrochelatase and inhibiting translation of ALAS2.	Iron	168-172	sideroflexin 4	Homo sapiens	0-5
31873120-7	2019	We conclude that SFXN4 is essential for normal functioning of mitochondria, is necessary for Fe-S cluster biogenesis and iron homeostasis, and plays a critical role in mitochondrial respiration and synthesis of heme.	Iron	121-125	sideroflexin 4	Homo sapiens	17-22
31712311-0	2019	mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma.	Iron	67-71	CREB regulated transcription coactivator 2	Mus musculus	0-6
31712311-3	2019	Integrated analyses in orthotopic mouse models and in clinical GBM samples reveal that mTORC2 controls iron metabolisms via histone H3 acetylation of the iron-related gene promoter, promoting tumor cell survival.	Iron	103-107	CREB regulated transcription coactivator 2	Mus musculus	87-93
31712311-3	2019	Integrated analyses in orthotopic mouse models and in clinical GBM samples reveal that mTORC2 controls iron metabolisms via histone H3 acetylation of the iron-related gene promoter, promoting tumor cell survival.	Iron	154-158	CREB regulated transcription coactivator 2	Mus musculus	87-93
31712311-4	2019	These results nominate mTORC2 as a critical epigenetic regulator of iron metabolism in cancer.	Iron	68-72	CREB regulated transcription coactivator 2	Mus musculus	23-29
31920940-2	2019	In this prospective, explorative study the iron accumulation in deep gray matter nuclei (DGM) in myotonic dystrophy type 1 (DM1) and 2 (DM2) and its clinical and neuro-cognitive relevance using susceptibility and R2* mapping was examined.	Iron	43-47	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	136-139
31920940-8	2019	Iron accumulation in DGM reflected by R2* or susceptibility was found in the putamen and accumbens of DM1 and in DM2, but was more widespread in DM1 (caudate, pallidum, hippocampus, subthalamic nucleus, thalamus, and substantia nigra).	Iron	0-4	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	113-116
31690920-3	2019	To demonstrate the applicability of RMCF to reactivity, we link the kinetic energy distribution within a reactive mode with the asynchronicity (eta) in C-H bond activation, as they both evolve in a series of coupled proton-electron transfer (CPET) reactions between FeIVO oxidants and 1,4-cyclohexadiene.	Iron	266-271	endothelin receptor type A	Homo sapiens	144-147
31591273-1	2019	The gene designated BAB_RS23470 in the Brucella abortus 2308 genome encodes an ortholog of the cation diffusion facilitator family protein EmfA which has been linked to resistance to Mn toxicity in Rhizobium etli A B. abortus emfA null mutant derived from strain 2308 displays increased sensitivity to elevated levels of Mn in the growth medium compared to the parent strain, but wild-type resistance to Fe, Mg, Zn, Cu, Co and Ni.	Iron	404-406	cation diffusion facilitator family transporter	Brucella abortus 2308	20-27
31878309-9	2019	PHO84, encoding the high-affinity phosphate transporter, was the most down-regulated gene in the mutant, and may be crucial in iron-resistance.	Iron	127-131	phosphate transporter PHO84	Saccharomyces cerevisiae S288C	0-5
31736291-0	2019	Electric-Field-Enhanced Bulk Perpendicular Magnetic Anisotropy in GdFe/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 Multiferroic Heterostructure.	Iron	66-70	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	74-77
31736291-2	2019	Here, we deposit amorphous GdFe ferrimagnetic films on Pb(Mg1/3Nb2/3)0.7Ti0.3O3 ferroelectric substrate and investigate the effect of electric-field-induced piezostrain on its bulk perpendicular magnetic anisotropy.	Iron	27-31	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	58-61
31736291-3	2019	The anomalous Hall effect and polar Kerr image measurements suggest an enhanced bulk perpendicular magnetic anisotropy by electric field, which originates from a positive magnetoelastic anisotropy due to the positive magnetostriction coefficient of the GdFe film and the electric-field-induced tensile strain along the z axis in Pb(Mg1/3Nb2/3)0.7Ti0.3O3 ferroelectric substrate.	Iron	253-257	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	332-335
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	50-54	transferrin receptor	Homo sapiens	146-168
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	50-54	transferrin receptor	Homo sapiens	170-174
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	106-110	transferrin receptor	Homo sapiens	146-168
31694367-1	2019	Cells are able to precisely control the amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis of the transferrin receptor 1 (TfR1).	Iron	106-110	transferrin receptor	Homo sapiens	170-174
31539545-5	2019	Iron management proteins lipocalin 2 (LCN2) and ferritin(FTL) exhibited distinct postinjury time courses, where peak LCN2 response preceded, and FTL followed that of HO-1.	Iron	0-4	lipocalin 2	Rattus norvegicus	25-36
31539545-5	2019	Iron management proteins lipocalin 2 (LCN2) and ferritin(FTL) exhibited distinct postinjury time courses, where peak LCN2 response preceded, and FTL followed that of HO-1.	Iron	0-4	lipocalin 2	Rattus norvegicus	38-42
31539545-5	2019	Iron management proteins lipocalin 2 (LCN2) and ferritin(FTL) exhibited distinct postinjury time courses, where peak LCN2 response preceded, and FTL followed that of HO-1.	Iron	0-4	lipocalin 2	Rattus norvegicus	117-121
31539545-6	2019	LCN2 elevation supported not only its role in iron transport, but also mediation of matrix metalloproteinase 9 (MMP9) activity.	Iron	46-50	lipocalin 2	Rattus norvegicus	0-4
31127639-0	2019	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	Iron	68-72	SMAD family member 5	Mus musculus	30-35
31127639-4	2019	We found that Smad8;Alb-Cre+ mice exhibited no iron phenotype, whereas Smad158;Alb-Cre+ mice had greater iron overload than Smad15;Alb-Cre+ mice.	Iron	105-109	albumin	Mus musculus	79-82
31127639-4	2019	We found that Smad8;Alb-Cre+ mice exhibited no iron phenotype, whereas Smad158;Alb-Cre+ mice had greater iron overload than Smad15;Alb-Cre+ mice.	Iron	105-109	albumin	Mus musculus	79-82
31127639-9	2019	Liver injury and fibrosis were prevented in Smad158;Alb-Cre+ mice by a low-iron diet and were minimal in iron-loaded Cre- mice.	Iron	75-79	albumin	Mus musculus	52-55
31324879-11	2019	The endogenous iron regulator erythroferrone reduced BMP2-SMAD1/5/8 signalling by ~30% specifically in subcutaneous abdominal preadipocytes (p &lt; 0.01), suggesting it plays a role in restricting the expansion of the body"s largest AT depot during energy deficiency.	Iron	15-19	bone morphogenetic protein 2	Homo sapiens	53-57
31324879-11	2019	The endogenous iron regulator erythroferrone reduced BMP2-SMAD1/5/8 signalling by ~30% specifically in subcutaneous abdominal preadipocytes (p &lt; 0.01), suggesting it plays a role in restricting the expansion of the body"s largest AT depot during energy deficiency.	Iron	15-19	SMAD family member 1	Homo sapiens	58-65
31106422-3	2019	Iron enters the cardiomyocyte through the classic pathway, by binding to the transferrin 1 receptor (TfR1), but also through other routes: T-type calcium channel (TTCC), divalent metal transporter 1 (DMT1), L-type calcium channel (LTCC), Zrt-, Irt-like Proteins (ZIP) 8 and 14.	Iron	0-4	transferrin receptor	Homo sapiens	77-99
31106422-3	2019	Iron enters the cardiomyocyte through the classic pathway, by binding to the transferrin 1 receptor (TfR1), but also through other routes: T-type calcium channel (TTCC), divalent metal transporter 1 (DMT1), L-type calcium channel (LTCC), Zrt-, Irt-like Proteins (ZIP) 8 and 14.	Iron	0-4	transferrin receptor	Homo sapiens	101-105
31106422-3	2019	Iron enters the cardiomyocyte through the classic pathway, by binding to the transferrin 1 receptor (TfR1), but also through other routes: T-type calcium channel (TTCC), divalent metal transporter 1 (DMT1), L-type calcium channel (LTCC), Zrt-, Irt-like Proteins (ZIP) 8 and 14.	Iron	0-4	solute carrier family 39 member 8	Homo sapiens	238-269
31106422-7	2019	When the cellular iron level is low, expression of IRPs increases and they reduce expression of FPN, inhibiting iron efflux, reduce ferritin expression, inhibiting iron storage and augment expression of TfR1, increasing cellular iron availability.	Iron	18-22	transferrin receptor	Homo sapiens	203-207
31804379-4	2019	Multivariate logistic regression analysis showed that a high intake of iron (odds ratio [OR]: 1.303, P = .004), low intake of vitamin A (OR: 0.365, P = .019), and vegetable fat (OR: 0.957, P = .004) were associated with an increased risk of glaucoma.Current findings showed that high iron intake and low vitamin A and vegetable fat intake appeared to be associated with an increased risk of glaucoma in subjects of Japanese descent living in the Los Angeles populations.	Iron	71-75	FAT atypical cadherin 1	Homo sapiens	328-331
31784520-7	2019	This interaction ensures nuclear translocation of holo-IRP1 and downregulation of iron-dependent processes, demonstrating that holo-IRP1 functions not just as an aconitase, but throttles target gene expression in anticipation of declining iron requirements.	Iron	239-243	aconitase 1	Homo sapiens	132-136
31584077-2	2019	This monogenic disease is caused by the hyper-expansion of naturally occurring GAA repeats in the first intron of the FXN gene, encoding for frataxin, a protein implicated in the biogenesis of iron-sulfur clusters.	Iron	193-197	frataxin	Homo sapiens	118-121
31584077-2	2019	This monogenic disease is caused by the hyper-expansion of naturally occurring GAA repeats in the first intron of the FXN gene, encoding for frataxin, a protein implicated in the biogenesis of iron-sulfur clusters.	Iron	193-197	frataxin	Homo sapiens	141-149
31554636-7	2019	Additionally, the HRI-eIF2alphaP-ATF4 pathway represses mechanistic target of rapamycin complex 1 (mTORC1) signaling, specifically in the erythroid lineage as a feedback mechanism of erythropoietin-stimulated erythropoiesis during iron/heme deficiency.	Iron	231-235	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	18-21
31554636-7	2019	Additionally, the HRI-eIF2alphaP-ATF4 pathway represses mechanistic target of rapamycin complex 1 (mTORC1) signaling, specifically in the erythroid lineage as a feedback mechanism of erythropoietin-stimulated erythropoiesis during iron/heme deficiency.	Iron	231-235	CREB regulated transcription coactivator 1	Mus musculus	99-105
31787896-4	2019	Here, we used a PAE rat model to analyze messenger RNA (mRNA) and protein expression of iron homeostasis genes such as transferrin receptor (TfR), divalent metal transporter (DMT1), ferroportin (FPN1), and ferritin (FT) in brain areas associated with memory formation such as the prefrontal cortex (PFC), ventral tegmental area, and hippocampus.	Iron	88-92	transferrin receptor	Rattus norvegicus	119-139
31787896-4	2019	Here, we used a PAE rat model to analyze messenger RNA (mRNA) and protein expression of iron homeostasis genes such as transferrin receptor (TfR), divalent metal transporter (DMT1), ferroportin (FPN1), and ferritin (FT) in brain areas associated with memory formation such as the prefrontal cortex (PFC), ventral tegmental area, and hippocampus.	Iron	88-92	transferrin receptor	Rattus norvegicus	141-144
31517402-4	2019	By introducing guest iron (Fe) ions into the core@shell MOF precursor, the open carbon cages are self-assembled into a hydrangea-like 3D superstructure interconnected by carbon nanotubes, which are grown in situ on the Fe-Co alloy nanoparticles formed during the pyrolysis of Fe-introduced Zn@Co-MOFs.	Iron	21-25	lysine acetyltransferase 8	Homo sapiens	56-59
31517402-4	2019	By introducing guest iron (Fe) ions into the core@shell MOF precursor, the open carbon cages are self-assembled into a hydrangea-like 3D superstructure interconnected by carbon nanotubes, which are grown in situ on the Fe-Co alloy nanoparticles formed during the pyrolysis of Fe-introduced Zn@Co-MOFs.	Iron	27-29	lysine acetyltransferase 8	Homo sapiens	56-59
31517402-4	2019	By introducing guest iron (Fe) ions into the core@shell MOF precursor, the open carbon cages are self-assembled into a hydrangea-like 3D superstructure interconnected by carbon nanotubes, which are grown in situ on the Fe-Co alloy nanoparticles formed during the pyrolysis of Fe-introduced Zn@Co-MOFs.	Iron	219-221	lysine acetyltransferase 8	Homo sapiens	56-59
31517402-4	2019	By introducing guest iron (Fe) ions into the core@shell MOF precursor, the open carbon cages are self-assembled into a hydrangea-like 3D superstructure interconnected by carbon nanotubes, which are grown in situ on the Fe-Co alloy nanoparticles formed during the pyrolysis of Fe-introduced Zn@Co-MOFs.	Iron	219-221	lysine acetyltransferase 8	Homo sapiens	56-59
31344531-0	2019	Exploring iron-binding to human frataxin and to selected Friedreich ataxia mutants by means of NMR and EPR spectroscopies.	Iron	10-14	frataxin	Homo sapiens	32-40
31344531-3	2019	Frataxin has been claimed to participate in iron homeostasis and biosynthesis of FeS clusters, however its role in both pathways is not unequivocally defined.	Iron	44-48	frataxin	Homo sapiens	0-8
31344531-4	2019	In this work we combined different advanced spectroscopic analyses to explore the iron-binding properties of human frataxin, as isolated and at the FeS clusters assembly machinery.	Iron	82-86	frataxin	Homo sapiens	115-123
31344531-6	2019	By 2D NMR, we confirmed that iron can be bound in both oxidation states, a controversial issue, and, in addition, we were able to point out a transient interaction of frataxin with a N-terminal 6his-tagged variant of ISCU, the scaffold protein of the FeS clusters assembly machinery.	Iron	29-33	frataxin	Homo sapiens	167-175
31373370-11	2019	Excess iron increased hippocampal lipid peroxidation by 74% (P &lt; 0.05) and decreased MBP by 44% (P = 0.053).	Iron	7-11	myelin basic protein	Homo sapiens	88-91
31603444-1	2019	Nutrient iron entering the blood binds transferrin (TFN)d, which delivers iron to cells in the body.	Iron	9-13	transferrin	Sus scrofa	39-50
31603444-1	2019	Nutrient iron entering the blood binds transferrin (TFN)d, which delivers iron to cells in the body.	Iron	74-78	transferrin	Sus scrofa	39-50
30683557-1	2019	Porphyria cutanea tarda (PCT) is the most common human porphyria, due to hepatic deficiency of uroporphyrinogen decarboxylase (UROD), which is acquired in the presence of iron overload and various susceptibility factors, such as alcohol abuse, smoking, hepatitis C virus (HCV) infection, HIV infection, iron overload with HFE gene mutations, use of estrogens, and UROD mutation.	Iron	171-175	uroporphyrinogen decarboxylase	Homo sapiens	95-125
30683557-1	2019	Porphyria cutanea tarda (PCT) is the most common human porphyria, due to hepatic deficiency of uroporphyrinogen decarboxylase (UROD), which is acquired in the presence of iron overload and various susceptibility factors, such as alcohol abuse, smoking, hepatitis C virus (HCV) infection, HIV infection, iron overload with HFE gene mutations, use of estrogens, and UROD mutation.	Iron	171-175	uroporphyrinogen decarboxylase	Homo sapiens	127-131
30683557-1	2019	Porphyria cutanea tarda (PCT) is the most common human porphyria, due to hepatic deficiency of uroporphyrinogen decarboxylase (UROD), which is acquired in the presence of iron overload and various susceptibility factors, such as alcohol abuse, smoking, hepatitis C virus (HCV) infection, HIV infection, iron overload with HFE gene mutations, use of estrogens, and UROD mutation.	Iron	303-307	uroporphyrinogen decarboxylase	Homo sapiens	95-125
30683557-1	2019	Porphyria cutanea tarda (PCT) is the most common human porphyria, due to hepatic deficiency of uroporphyrinogen decarboxylase (UROD), which is acquired in the presence of iron overload and various susceptibility factors, such as alcohol abuse, smoking, hepatitis C virus (HCV) infection, HIV infection, iron overload with HFE gene mutations, use of estrogens, and UROD mutation.	Iron	303-307	uroporphyrinogen decarboxylase	Homo sapiens	127-131
30737139-7	2019	Mice modeling the hepatocutaneous porphyria, porphyria cutanea tarda (PCT), made possible the identification of the iron-dependent inhibitory mechanism of uroporphyrinogen decarboxylase (UROD) that leads to symptomatic PCT.	Iron	116-120	uroporphyrinogen decarboxylase	Mus musculus	155-185
30737139-7	2019	Mice modeling the hepatocutaneous porphyria, porphyria cutanea tarda (PCT), made possible the identification of the iron-dependent inhibitory mechanism of uroporphyrinogen decarboxylase (UROD) that leads to symptomatic PCT.	Iron	116-120	uroporphyrinogen decarboxylase	Mus musculus	187-191
30737140-9	2019	ALAS2 mRNA translation is also regulated by the iron-responsive element (IRE)/iron regulatory proteins (IRP) binding system.	Iron	48-52	5'-aminolevulinate synthase 2	Homo sapiens	0-5
30737140-9	2019	ALAS2 mRNA translation is also regulated by the iron-responsive element (IRE)/iron regulatory proteins (IRP) binding system.	Iron	78-82	5'-aminolevulinate synthase 2	Homo sapiens	0-5
31679808-8	2019	CONCLUSION: The impact of detection of HFE mutations could prognosis the likelihood of iron overload in multi-transfused patients, and allowing early diagnosis and proper management to overcome complications of iron overload in beta-thalassemia patients.	Iron	87-91	homeostatic iron regulator	Homo sapiens	39-42
31679808-8	2019	CONCLUSION: The impact of detection of HFE mutations could prognosis the likelihood of iron overload in multi-transfused patients, and allowing early diagnosis and proper management to overcome complications of iron overload in beta-thalassemia patients.	Iron	211-215	homeostatic iron regulator	Homo sapiens	39-42
31560858-1	2019	Hereditary aceruloplasminemia (HA), related to mutations in the ceruloplasmin (Cp) gene, leads to iron accumulation.	Iron	98-102	ceruloplasmin	Rattus norvegicus	12-25
31069605-11	2019	OA + Fe and OA + Zn displayed significant decrease in DTH, NO, expression of IL-4, 5, 13, 17, toll-like receptor-2, nuclear factor-kappa B and tumor necrosis factor-alpha; serum IgE, COX-2, and 5-LOX.	Iron	5-7	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	183-188
31727545-12	2019	DISCUSSION: Increase in non-haem iron prior to induction of HO-1 expression suggests the involvement of HO-2 in haem-induced cytotoxicity.	Iron	33-37	heme oxygenase 2	Homo sapiens	104-108
31687798-2	2019	Herein, cation-disordered rocksalt-type Li-Fe-Ti oxides of Li0.89Fe0.44Ti0.45O2, Li1.18Fe0.34Ti0.45O2, and Li1.24Fe0.38Ti0.38O2 with different Li-to-transition metal ratios (Li/TM = 1, 1.49, or 1.63) are investigated to understand the effect of a Li excess on the electrochemical Li-ion storage properties.	Iron	43-45	transglutaminase 1	Homo sapiens	81-84
31850005-0	2019	Mitochondrial Iron Transporters (MIT1 and MIT2) Are Essential for Iron Homeostasis and Embryogenesis in Arabidopsis thaliana.	Iron	14-18	Mit1p	Saccharomyces cerevisiae S288C	33-37
31850005-0	2019	Mitochondrial Iron Transporters (MIT1 and MIT2) Are Essential for Iron Homeostasis and Embryogenesis in Arabidopsis thaliana.	Iron	66-70	Mit1p	Saccharomyces cerevisiae S288C	33-37
31850005-4	2019	Here, we describe the Arabidopsis mitochondrial iron transporters, MIT1 and MIT2, that belong to the mitochondrial carrier family (MCF) of transport proteins.	Iron	48-52	Mit1p	Saccharomyces cerevisiae S288C	67-71
31850005-5	2019	MIT1 and MIT2 display considerable homology with known mitochondrial Fe transporters of other organisms.	Iron	69-71	Mit1p	Saccharomyces cerevisiae S288C	0-4
31402362-2	2019	Here we show that respiratory growth and iron acquisition by the yeast Saccharomyces cerevisiae relies on potassium (K+) compartmentalization to the mitochondria, as well as the vacuole and late endosome via K+/H+ exchangers Mdm38p, Vnx1p and Nhx1p, respectively.	Iron	41-45	ribosome-binding protein MDM38	Saccharomyces cerevisiae S288C	225-231
31402362-5	2019	The results suggest that the vacuole and late endosome are important potassium storage vesicles and Mdm38p affects the mitochondrial function by regulating copper and iron metabolism.	Iron	167-171	ribosome-binding protein MDM38	Saccharomyces cerevisiae S288C	100-106
31850005-6	2019	Expression of MIT1 or MIT2 rescues the phenotype of the yeast mrs3mrs4 mutant, which is defective in mitochondrial iron transport.	Iron	115-119	Mit1p	Saccharomyces cerevisiae S288C	14-18
33126466-2	2020	FRDA is caused by reduced levels of frataxin (FXN), a mitochondrial protein involved in the synthesis of iron-sulphur clusters, leading to iron accumulation at the mitochondrial level, uncontrolled production of reactive oxygen species and lipid peroxidation.	Iron	105-109	frataxin	Homo sapiens	36-44
31850005-8	2019	Analysis of a mit1 -- /mit2 + - line revealed that MIT1 and MIT2 are essential for iron acquisition by mitochondria and proper mitochondrial function.	Iron	83-87	Mit1p	Saccharomyces cerevisiae S288C	14-18
31850005-8	2019	Analysis of a mit1 -- /mit2 + - line revealed that MIT1 and MIT2 are essential for iron acquisition by mitochondria and proper mitochondrial function.	Iron	83-87	Mit1p	Saccharomyces cerevisiae S288C	51-55
33126466-2	2020	FRDA is caused by reduced levels of frataxin (FXN), a mitochondrial protein involved in the synthesis of iron-sulphur clusters, leading to iron accumulation at the mitochondrial level, uncontrolled production of reactive oxygen species and lipid peroxidation.	Iron	105-109	frataxin	Homo sapiens	46-49
31850005-10	2019	Thus, MIT1 and MIT2 are required for the maintenance of both mitochondrial and whole plant Fe homeostasis, which, in turn, is important for the proper growth and development of the plant.	Iron	91-93	Mit1p	Saccharomyces cerevisiae S288C	6-10
32521073-0	2020	MOF-Mediated Synthesis of Supported Fe-doped Pd Nanoparticles under Mild Conditions for Magnetically Recoverable Catalysis.	Iron	36-38	lysine acetyltransferase 8	Homo sapiens	0-3
33404549-9	2020	XFI coupled with XAS further revealed that loss of PIN2 function results in specific accumulation of arsenical species, but not the other metals such as iron, zinc, or calcium in the root tip.	Iron	153-157	Auxin efflux carrier family protein	Arabidopsis thaliana	51-55
31429849-2	2019	The yeast adrenodoxin reductase homolog, Arh1p, is involved in cytoplasmic and mitochondrial iron homeostasis and is required for activity of enzymes containing an Fe-S cluster.	Iron	93-97	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	41-46
31429849-2	2019	The yeast adrenodoxin reductase homolog, Arh1p, is involved in cytoplasmic and mitochondrial iron homeostasis and is required for activity of enzymes containing an Fe-S cluster.	Iron	164-168	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	41-46
31429849-5	2019	However, a considered investigation of transcriptional regulation in ARH1-impaired yeast highlighted that a significant hierarchical reorganisation occurred, involving the iron assimilation and tyrosine biosynthetic processes.	Iron	172-176	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	69-73
31441223-4	2019	Mechanistically, we show that iron overload leads to a decrease in Akt-mediated repression of tuberous sclerosis complex (TSC2) and Rheb-mediated mTORC1 activation on autolysosomes, thereby inhibiting autophagic-lysosome regeneration.	Iron	30-34	Ras homolog enriched in brain	Mus musculus	132-136
31441223-4	2019	Mechanistically, we show that iron overload leads to a decrease in Akt-mediated repression of tuberous sclerosis complex (TSC2) and Rheb-mediated mTORC1 activation on autolysosomes, thereby inhibiting autophagic-lysosome regeneration.	Iron	30-34	CREB regulated transcription coactivator 1	Mus musculus	146-152
31686500-1	2019	Time-resolved transient absorption spectroscopy and computational analysis of D-pi-A complexes comprising FeII donors and TiIV acceptors with the general formula RCp2Ti(C2Fc)2 (where RCp = Cp*, Cp, and MeOOCCp) and TMSCp2Ti(C2Fc)(C2R) (where R = Ph or CF3) are reported.	Iron	106-110	CGRP receptor component	Homo sapiens	162-165
31441223-5	2019	Constitutive activation of mTORC1 or iron withdrawal replenishes lysosomal pools via increased mTORC1-UVRAG signaling, which restores insulin sensitivity.	Iron	37-41	CREB regulated transcription coactivator 1	Mus musculus	95-101
32521073-2	2020	This synthetic approach is used here to gradually transform a new bimetallic MOF, composed of Pd and Fe as metal components, via the in situ generation of aniline under mild conditions.	Iron	101-103	lysine acetyltransferase 8	Homo sapiens	77-80
31441223-6	2019	Induction of iron overload via intravenous iron-dextran delivery in mice also results in insulin resistance accompanied by abnormal autophagosome accumulation, lysosomal loss, and decreased mTORC1-UVRAG signaling in muscle.	Iron	13-17	CREB regulated transcription coactivator 1	Mus musculus	190-196
31441223-7	2019	Collectively, our results show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.	Iron	44-48	CREB regulated transcription coactivator 1	Mus musculus	103-109
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	10-14	transferrin receptor	Homo sapiens	65-69
31687022-8	2019	Per Glu380Lys, Glu with negative charges has been changed into Lys with positive charges, which may affect the hydrogen bond formation between amino acids and the stability of the local structure, thus affecting the binding of zinc iron to MKRN3 protein.	Iron	232-236	makorin ring finger protein 3	Homo sapiens	240-245
31781104-3	2019	Whereas, the ability of Lcn2 to sequester iron is well-described, the role of Lcn2 in regulating immune cells during bacterial infection remains unclear.	Iron	42-46	lipocalin 2	Mus musculus	24-28
31693663-6	2019	Using a systems approach that combines GWAS, network-based candidate identification, and reverse genetic screen, we identified new genes that regulate root growth in -P-Fe: VIM1, FH6, and VDAC3.	Iron	169-171	voltage dependent anion channel 3	Arabidopsis thaliana	188-193
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	10-14	transferrin receptor	Homo sapiens	71-74
31440902-2	2019	Frataxin plays an essential role in cellular iron regulation and has been shown to participate in the assembly of iron-sulfur (Fe-S) clusters under a variety of roles, including modulating persulfide production and directing Fe(II) delivery to the assembly scaffold protein.	Iron	45-49	frataxin	Drosophila melanogaster	0-8
31440902-2	2019	Frataxin plays an essential role in cellular iron regulation and has been shown to participate in the assembly of iron-sulfur (Fe-S) clusters under a variety of roles, including modulating persulfide production and directing Fe(II) delivery to the assembly scaffold protein.	Iron	127-131	frataxin	Drosophila melanogaster	0-8
31603317-1	2019	Iron electrocoagulation (Fe EC) is normally considered as a separation process.	Iron	0-4	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	14-15
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	10-14	transferrin receptor	Homo sapiens	158-162
31603317-8	2019	The reactive oxidants produced at 30 mA (or 60 mA/L) could degrade about 47% of 10 muM aniline and 34% of sulfanilamide within 6 h of Fe EC treatment.	Iron	134-136	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	47-51
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	135-139	transferrin receptor	Homo sapiens	65-69
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	135-139	transferrin receptor	Homo sapiens	71-74
31685805-5	2019	In particular, glutathione peroxidase 4 (GPX4), which protects cells from ferroptosis (an iron-dependent programme of regulated necrosis), was downregulated in the early and middle stages of MI.	Iron	90-94	glutathione peroxidase 4	Rattus norvegicus	15-39
33110194-2	2020	Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed.	Iron	135-139	transferrin receptor	Homo sapiens	158-162
31685805-5	2019	In particular, glutathione peroxidase 4 (GPX4), which protects cells from ferroptosis (an iron-dependent programme of regulated necrosis), was downregulated in the early and middle stages of MI.	Iron	90-94	glutathione peroxidase 4	Rattus norvegicus	41-45
31329346-1	2019	Herein, we report on the first synthesis and structural characterization of the iron based aminoborane complexes [Fe(PNP)(H)(eta2 :eta2 -H2 B=NR2 )]+ (R=H, Me).	Iron	80-84	DNA polymerase iota	Homo sapiens	125-129
33110194-3	2020	Here, we demonstrate that CD71 utilizes heme-albumin as cargo to transport iron into human cells.	Iron	75-79	transferrin receptor	Homo sapiens	26-30
31329346-1	2019	Herein, we report on the first synthesis and structural characterization of the iron based aminoborane complexes [Fe(PNP)(H)(eta2 :eta2 -H2 B=NR2 )]+ (R=H, Me).	Iron	80-84	DNA polymerase iota	Homo sapiens	131-135
32556142-3	2020	Targeting Tmprss6 mRNA by Tmprss6-ASO was proven to be effective in improving the IE and splenomegaly by inducing iron restriction.	Iron	114-118	transmembrane serine protease 6	Mus musculus	10-17
31206850-3	2019	Phosvitin was chosen as a relevant model for phosphorylated proteins because of its important role as an iron, calcium, and magnesium storage protein in egg yolk.	Iron	105-109	casein kinase 2 beta	Homo sapiens	0-9
31419721-1	2019	The transferrin receptor 1 (TfR1) is one of the key regulators of iron homeostasis for most higher organisms.	Iron	66-70	transferrin receptor	Homo sapiens	4-26
31419721-1	2019	The transferrin receptor 1 (TfR1) is one of the key regulators of iron homeostasis for most higher organisms.	Iron	66-70	transferrin receptor	Homo sapiens	28-32
31419721-2	2019	It mediates cellular iron import through a constitutive clathrin-dependent endocytosis mechanism and by recruiting iron- regulator proteins as transferrin, Hereditary Hemochromatosis factor (HFE) and serum ferritin in response to cellular demand.	Iron	21-25	homeostatic iron regulator	Homo sapiens	191-194
31419721-4	2019	In this review, we analyze the structural information available for TfR1 and all its functional complexes to figure out how structural signals in a single receptor can guide the recognition of multiple ligands and how the conservation of key residues in TfR1 might have a role in iron uptake and cell infection.	Iron	280-284	transferrin receptor	Homo sapiens	68-72
31419721-4	2019	In this review, we analyze the structural information available for TfR1 and all its functional complexes to figure out how structural signals in a single receptor can guide the recognition of multiple ligands and how the conservation of key residues in TfR1 might have a role in iron uptake and cell infection.	Iron	280-284	transferrin receptor	Homo sapiens	254-258
32556142-3	2020	Targeting Tmprss6 mRNA by Tmprss6-ASO was proven to be effective in improving the IE and splenomegaly by inducing iron restriction.	Iron	114-118	transmembrane serine protease 6	Mus musculus	26-33
31442590-8	2019	In mice, iron and MDA levels were significantly increased 3 h after ICH; COX-2 levels were increased at 12 h after ICH and peaked at 3 days after ICH; COX-2 colocalized with NeuN (a neuronal biomarker); and TEM showed that shrunken mitochondria were found at 3 h, 3 days, and 7 days after ICH.	Iron	9-13	RNA binding protein, fox-1 homolog (C. elegans) 3	Mus musculus	174-178
31469562-5	2019	Here we report the mechanism of the complete reaction steps catalyzed by a representative nonheme iron alphaKG-dependent KDM, PHF8 using QM/MM approaches.	Iron	98-102	PHD finger protein 8	Homo sapiens	126-130
32556142-8	2020	To overcome this issue, we postulated that some level of iron restriction (by targeting Tmprss6) would improve the splenomegaly while preserving the beneficial effects on RBC production mediated by EPO or Tfr2 deletion.	Iron	57-61	transmembrane serine protease 6	Mus musculus	88-95
32800558-0	2020	Transferrin1 modulates rotenone-induced Parkinson"s disease through affecting iron homeostasis in Drosophila melanogaster.	Iron	78-82	Transferrin 1	Drosophila melanogaster	0-12
32800558-6	2020	We found that inhibition of transferrin1 (Tsf1) expression in the central nervous system (CNS) results in reduced iron levels in brains and significantly ameliorates the neurodegenerative phenotypes of rotenone exposure Drosophila; moreover, the rotenone induced reactive oxygen species (ROS) levels in the brain, the damaged complex I activity and the decreased ATP generation were dramatically rescued by Tsf1 knockdown.	Iron	114-118	Transferrin 1	Drosophila melanogaster	28-40
31532389-0	2019	NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling.	Iron	43-47	Nuclear hormone receptor family member nhr-14	Caenorhabditis elegans	0-6
31401526-7	2019	Moreover, significantly changed expression of TFRC, FTL and FTH1 hinted that dysfunction of iron uptake and storage is a major inducer of ferroptosis.	Iron	92-96	transferrin receptor	Homo sapiens	46-50
31532389-5	2019	Here we identify nhr-14, encoding a nuclear receptor, in a screen conducted for mutations that rescue the developmental delay of hif-1 mutants under iron limitation.	Iron	149-153	Nuclear hormone receptor family member nhr-14	Caenorhabditis elegans	17-23
32800558-6	2020	We found that inhibition of transferrin1 (Tsf1) expression in the central nervous system (CNS) results in reduced iron levels in brains and significantly ameliorates the neurodegenerative phenotypes of rotenone exposure Drosophila; moreover, the rotenone induced reactive oxygen species (ROS) levels in the brain, the damaged complex I activity and the decreased ATP generation were dramatically rescued by Tsf1 knockdown.	Iron	114-118	Transferrin 1	Drosophila melanogaster	42-46
31532389-6	2019	nhr-14 loss upregulates the intestinal metal transporter SMF-3 to increase iron uptake in hif-1 mutants.	Iron	75-79	Nuclear hormone receptor family member nhr-14	Caenorhabditis elegans	0-6
33123307-5	2020	Furthermore, we revealed that iron overload-induced osteoblastic necrosis might be mediated via the RIPK1/RIPK3/MLKL necroptotic pathway.	Iron	30-34	mixed lineage kinase domain like pseudokinase	Homo sapiens	112-116
31517438-0	2019	Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma"s cyclin D1.	Iron	0-4	cyclin D1	Homo sapiens	99-108
31517438-2	2019	We observed that iron (an essential cofactor of dioxygenases including prolyl hydroxylases [PHDs]) depletion by deferoxamine blocked MCL cells" proliferation, increased expression of DNA damage marker gammaH2AX, induced cell cycle arrest and decreased cyclin D1 level.	Iron	17-21	cyclin D1	Homo sapiens	252-261
32643319-7	2020	We find a quasi-Mars-van-Krevelen (quasi-MvK) surface reaction mechanism involving extracting and refilling the surface carbon atoms for the nonoxidative conversion of methane on Fe 1  SiO 2 and this new surface process is identified to be more plausible than the alternative gas-phase reaction mechanism.	Iron	179-181	mevalonate kinase	Homo sapiens	41-44
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Iron	249-253	cyclin D1	Homo sapiens	38-47
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Iron	249-253	cyclin D1	Homo sapiens	181-190
31511561-6	2019	Knockdown of ABCB7 in H9C2 cells and stimulation with angiotensin II resulted in increased ROS levels, ferritin, and transferrin receptor expression and iron overload in both mitochondria and cytoplasm.	Iron	153-157	ATP binding cassette subfamily B member 7	Rattus norvegicus	13-18
31511561-9	2019	ABCB7 was found to interact with mitochondrial complexes IV and V. We conclude that in chronic pressure overload, ABCB7 deficiency results in iron overload and mitochondrial dysfunction, contributing to heart failure.	Iron	142-146	ATP binding cassette subfamily B member 7	Rattus norvegicus	0-5
32735914-0	2020	Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: Implications for insect iron homeostasis.	Iron	0-4	Transferrin 1	Drosophila melanogaster	39-52
31551768-13	2019	In addition, Fe complex could suppress cell proliferation by downregulating reactive oxygen species levels via scavenging free radicals and interaction with TrxR.	Iron	13-15	peroxiredoxin 2	Mus musculus	157-161
31076252-6	2019	When iron is limited, iron response element binding protein 2 (IRP2) binds to the IRE of ALAS2 mRNA and suppresses its translation.	Iron	5-9	5'-aminolevulinate synthase 2	Homo sapiens	89-94
31076252-6	2019	When iron is limited, iron response element binding protein 2 (IRP2) binds to the IRE of ALAS2 mRNA and suppresses its translation.	Iron	22-26	5'-aminolevulinate synthase 2	Homo sapiens	89-94
31076252-7	2019	In this study, we demonstrated that iron deprivation increased the amount of ALAS2 mRNA as well as the ratio of ALAS2 to FECH mRNAs in cultured erythroleukemic K562 cells.	Iron	36-40	5'-aminolevulinate synthase 2	Homo sapiens	77-82
31076252-7	2019	In this study, we demonstrated that iron deprivation increased the amount of ALAS2 mRNA as well as the ratio of ALAS2 to FECH mRNAs in cultured erythroleukemic K562 cells.	Iron	36-40	5'-aminolevulinate synthase 2	Homo sapiens	112-117
31074541-1	2019	Human frataxin is an iron-binding protein involved in the mitochondrial iron-sulfur (Fe-S) clusters assembly, a process fundamental for the functional activity of mitochondrial proteins.	Iron	21-25	frataxin	Homo sapiens	6-14
31074541-1	2019	Human frataxin is an iron-binding protein involved in the mitochondrial iron-sulfur (Fe-S) clusters assembly, a process fundamental for the functional activity of mitochondrial proteins.	Iron	85-89	frataxin	Homo sapiens	6-14
32735914-0	2020	Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: Implications for insect iron homeostasis.	Iron	125-129	Transferrin 1	Drosophila melanogaster	39-52
31478326-7	2019	Further gene-diet interactions were reported for, eg, a western dietary pattern with a T2D-GRS, fat and carbohydrate with IRS1 rs2943641, and heme iron with variants of HFE.	Iron	147-151	homeostatic iron regulator	Homo sapiens	169-172
32735914-4	2020	To reconcile the apparent contradiction between the known physiological functions and predicted biochemical properties of Tsf1s, we purified and characterized the iron-binding properties of Drosophila melanogaster Tsf1 (DmTsf1), Manduca sexta Tsf1 (MsTsf1), and the amino-lobe of DmTsf1 (DmTsf1N).	Iron	163-167	Transferrin 1	Drosophila melanogaster	122-126
32966601-5	2020	Phosvitin, which has many functional features thanks to its unique structure, is known primarily for its metal bonds binding (iron, calcium, etc.)	Iron	126-130	casein kinase 2 beta	Homo sapiens	0-9
31439541-3	2019	In MEP of Transmembrane serine protease 6 knockout (Tmprss6-/- ) mice, which exhibit iron deficiency anemia and thrombocytosis, we observed a Mk bias, decreased labile iron, and decreased proliferation relative to wild-type (WT) MEP.	Iron	85-89	transmembrane serine protease 6	Mus musculus	10-41
31439541-3	2019	In MEP of Transmembrane serine protease 6 knockout (Tmprss6-/- ) mice, which exhibit iron deficiency anemia and thrombocytosis, we observed a Mk bias, decreased labile iron, and decreased proliferation relative to wild-type (WT) MEP.	Iron	85-89	transmembrane serine protease 6	Mus musculus	52-59
31220756-2	2019	Heme regulatory motifs (HRMs) are conserved in the two IRP homologues IRP1 and IRP2 that specifically bind to two and three heme equivalents, respectively; however, only the heme binding to the iron-dependent degradation (IDD) domain of IRP2 causes heme-mediated oxidation, which does not occur in IRP1.	Iron	194-198	Wnt family member 2	Homo sapiens	55-58
31220756-2	2019	Heme regulatory motifs (HRMs) are conserved in the two IRP homologues IRP1 and IRP2 that specifically bind to two and three heme equivalents, respectively; however, only the heme binding to the iron-dependent degradation (IDD) domain of IRP2 causes heme-mediated oxidation, which does not occur in IRP1.	Iron	194-198	aconitase 1	Homo sapiens	70-74
31220756-2	2019	Heme regulatory motifs (HRMs) are conserved in the two IRP homologues IRP1 and IRP2 that specifically bind to two and three heme equivalents, respectively; however, only the heme binding to the iron-dependent degradation (IDD) domain of IRP2 causes heme-mediated oxidation, which does not occur in IRP1.	Iron	194-198	aconitase 1	Homo sapiens	298-302
31345363-5	2019	The aims of this study were to investigate the status of NOX1, NOX4 and NOX5 and its relationship with serum iron metabolism biomarkers in relapsing-remitting MS patients.	Iron	109-113	NADPH oxidase 1	Homo sapiens	57-61
32966601-8	2020	Although this feature of phosvitin may partially decrease the bioavailability of especially iron in the egg, it allows the phosvitin to have many bioactivities in the food industry and health.	Iron	92-96	casein kinase 2 beta	Homo sapiens	25-34
31303184-0	2019	Iron Status and Inherited Hemoglobin Disorders Modify the Effects of Micronutrient Powders on Linear Growth and Morbidity among Young Lao Children in a Double-Blind Randomized Trial.	Iron	0-4	interleukin 4 induced 1	Homo sapiens	134-137
32966601-9	2020	Lipid oxidation, which is a serious problem in the food industry, can be inhibited by adding phosvitin and its derived phosphopeptides to the food production chain via inhibiting bivalent iron.	Iron	188-192	casein kinase 2 beta	Homo sapiens	93-102
32564977-5	2020	Cellular iron metabolism is post-transcriptionally controlled by iron regulatory proteins, IRP1 and IRP2, while systemic iron balance is regulated by the iron hormone hepcidin.	Iron	9-13	aconitase 1	Homo sapiens	91-95
31165152-4	2019	Previously, we showed that ZmZIP5 functionally complemented the Zn uptake double mutant zrt1zrt2, Fe-uptake double mutant fet3fet4 in yeast.	Iron	98-100	ferroxidase FET3	Saccharomyces cerevisiae S288C	122-130
32793311-8	2020	Furthermore, erastin-induced breast cancer cell death was inhibited by an iron chelator, deferoxamine, which inhibited the increases of erastin-induced iron levels and inhibited the erastin-induced changes in the expression levels of the autophagy-related proteins beclin1, ATG5, ATG12, LC3B and P62.	Iron	74-78	microtubule associated protein 1 light chain 3 beta	Homo sapiens	287-291
31659150-5	2019	Furthermore, we show that autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/- and LC3B-/-.	Iron	45-49	transferrin receptor	Homo sapiens	116-138
31659150-5	2019	Furthermore, we show that autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/- and LC3B-/-.	Iron	45-49	transferrin receptor	Homo sapiens	140-144
31659150-5	2019	Furthermore, we show that autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/- and LC3B-/-.	Iron	45-49	microtubule associated protein 1 light chain 3 beta	Homo sapiens	218-222
32935207-0	2021	Serum Iron and Ferritin Levels Are Correlated with Complement C3.	Iron	6-10	complement component 3	Mus musculus	51-64
31640150-2	2019	The loss of frataxin in patients results in iron sulfur cluster deficiency and iron accumulation in the mitochondria, making FRDA a fatal and debilitating condition.	Iron	44-48	frataxin	Homo sapiens	12-20
32935207-4	2021	The aim of our study was to analyze the relationship between serum iron and ferritin level and complement C3 and C4.	Iron	67-71	complement component 3	Mus musculus	95-108
32935207-7	2021	Moreover, serum iron level and serum ferritin level were positively correlated with complement C3 (r = 0.133, p = 0.001; r = 0.221, p < 0.001) and complement C4 (r = 0.117, p = 0.004; r = 0.123, p = 0.003).	Iron	16-20	complement component 3	Mus musculus	84-97
32935207-8	2021	The linear regression analysis displayed that both serum iron level and serum ferritin level were linearly correlated with serum complement C3 level (adjusted beta: 2.382, 95% CI: 0.841-3.923; adjusted beta: 42.911, 95% CI: 29.070-56.751).	Iron	57-61	complement component 3	Mus musculus	129-142
31615146-7	2019	Our results suggest that the dietary consumption of chia seeds may improve intestinal health and functionality and may indirectly improve iron and zinc intestinal absorption.	Iron	138-142	acidic mammalian chitinase	Gallus gallus	52-56
32935207-10	2021	Significantly lower serum iron level and higher ferritin level were found in C3-/- mice than those in WT mice (p < 0.001; p < 0.001), indicating that complement C3 might influence iron distribution and utilization.	Iron	26-30	complement component 3	Mus musculus	150-163
31597263-1	2019	In our previous study, Deferoxamine (DFO) increased the iron concentration by upregulating the expression levels of TfR1 and DMT1 and exacerbated the migration of triple-negative breast cancer cells.	Iron	56-60	transferrin receptor	Homo sapiens	116-120
32935207-10	2021	Significantly lower serum iron level and higher ferritin level were found in C3-/- mice than those in WT mice (p < 0.001; p < 0.001), indicating that complement C3 might influence iron distribution and utilization.	Iron	180-184	complement component 3	Mus musculus	150-163
32935207-11	2021	Overall, these data suggested that serum iron and ferritin levels were correlated with complement C3.	Iron	41-45	complement component 3	Mus musculus	87-100
32944219-9	2020	Conclusions: We propose that oxidative stress from POR1 over-expression, resulting in impaired activity of ISC containing proteins and disruptions in iron homeostasis, may play a role in disease pathogenesis in SDS patients.	Iron	150-154	ADP ribosylation factor interacting protein 2	Homo sapiens	51-55
31549710-3	2019	By rationally tuning the Ni/Fe ratio in deep eutectic solvent plating solution, the best oxygen evolution reaction performance was achieved by a Ni75Fe25 catalyst, which requires only a 316 mV overpotential to reach a current density of 10 mA cm-2, while its Tafel slope is as low as 62 mV dec-1.	Iron	28-30	deleted in esophageal cancer 1	Homo sapiens	290-295
32510613-1	2020	Transferrin-bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis.	Iron	18-22	transferrin receptor	Homo sapiens	104-124
31419396-1	2019	Ferritin-like proteins, Dps (DNA-binding protein from starved cells), store iron and play a key role in the iron homeostasis in bacteria, yet their iron releasing machinery remains largely unexplored.	Iron	76-80	decaprenyl diphosphate synthase subunit 1	Homo sapiens	24-27
31419396-1	2019	Ferritin-like proteins, Dps (DNA-binding protein from starved cells), store iron and play a key role in the iron homeostasis in bacteria, yet their iron releasing machinery remains largely unexplored.	Iron	108-112	decaprenyl diphosphate synthase subunit 1	Homo sapiens	24-27
31419396-1	2019	Ferritin-like proteins, Dps (DNA-binding protein from starved cells), store iron and play a key role in the iron homeostasis in bacteria, yet their iron releasing machinery remains largely unexplored.	Iron	108-112	decaprenyl diphosphate synthase subunit 1	Homo sapiens	24-27
31419396-2	2019	The electron donor proteins that may interact with Dps and promote the mobilization of the stored iron have hitherto not been identified.	Iron	98-102	decaprenyl diphosphate synthase subunit 1	Homo sapiens	51-54
31419396-8	2019	The results support our hypothesis that ferredoxins could be involved in cellular iron homeostasis by interacting with Dps and assisting the release of stored iron.	Iron	82-86	decaprenyl diphosphate synthase subunit 1	Homo sapiens	119-122
32510613-1	2020	Transferrin-bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis.	Iron	18-22	transferrin receptor	Homo sapiens	126-130
32510613-1	2020	Transferrin-bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis.	Iron	60-64	transferrin receptor	Homo sapiens	104-124
32510613-1	2020	Transferrin-bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis.	Iron	60-64	transferrin receptor	Homo sapiens	126-130
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	165-169	bone morphogenetic protein 2	Homo sapiens	28-31
31317428-4	2019	Frataxin is involved in mitochondrial iron homeostasis and the assembly and transfer of iron-sulfur clusters to various mitochondrial enzymes and components of the electron transport chain.	Iron	38-42	frataxin	Homo sapiens	0-8
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	165-169	bone morphogenetic protein 2	Homo sapiens	41-44
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	165-169	bone morphogenetic protein 2	Homo sapiens	41-44
31168664-7	2019	NH4+ also increases soluble Fe levels in shoots by upregulating genes involved in Fe translocation, such as FRD3 (FERRIC REDUCTASE DEFECTIVE3) and NAS1 (NICOTIANAMINE SYNTHASE1), hence, alleviating leaf chlorosis.	Iron	28-30	nicotianamine synthase 1	Arabidopsis thaliana	147-151
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	165-169	SMAD family member 1	Homo sapiens	61-65
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	bone morphogenetic protein 2	Homo sapiens	28-31
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	bone morphogenetic protein 2	Homo sapiens	41-44
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	bone morphogenetic protein 2	Homo sapiens	41-44
31612128-4	2019	It was found that the hierarchical-pore Fe-HK-2 exhibited optimal textural properties with high BET surface area of 1,707 m2/g and total pore volume of 0.93 cm3/g, which were higher than those of the unmodified HKUST-1.	Iron	40-42	hexokinase 2	Homo sapiens	43-47
31612128-4	2019	It was found that the hierarchical-pore Fe-HK-2 exhibited optimal textural properties with high BET surface area of 1,707 m2/g and total pore volume of 0.93 cm3/g, which were higher than those of the unmodified HKUST-1.	Iron	40-42	delta/notch like EGF repeat containing	Homo sapiens	96-99
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	bone morphogenetic protein 2	Homo sapiens	28-31
31612128-5	2019	Significantly, the hierarchical-pore Fe-HK-2 possessed outstanding benzene adsorption capacity, which was 1.5 times greater than the value on HKUST-1.	Iron	37-39	hexokinase 2	Homo sapiens	40-44
31612128-6	2019	Benzene diffusivity of Fe-HK-2 was 1.7 times faster than that of parent HKUST-1.	Iron	23-25	hexokinase 2	Homo sapiens	26-30
31612128-7	2019	Furthermore, the benzene adsorption on Fe-HK-2 was highly reversible.	Iron	39-41	hexokinase 2	Homo sapiens	42-46
31612128-8	2019	The hierarchical-pore Fe-HK-2 with high porosity, outstanding adsorption capacity, enhanced diffusion rate, and excellent reversibility might be an attractive candidate for VOCs adsorption.	Iron	22-24	hexokinase 2	Homo sapiens	25-29
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	bone morphogenetic protein 2	Homo sapiens	41-44
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	bone morphogenetic protein 2	Homo sapiens	41-44
32585319-6	2020	Pharmacologic modulators of the BMP-SMAD pathway have shown efficacy in pre-clinical models to regulate hepcidin expression and treat iron-related disorders.	Iron	134-138	bone morphogenetic protein 2	Homo sapiens	32-35
31554244-5	2019	Heme toxicity, which may lead to iron toxicity, is recognized increasingly in a wide range of conditions involving hemolysis and immune system activation and, in this review, we highlight some newly identified actions of heme and hemopexin especially in situations where normal processes fail to maintain heme and iron homeostasis.	Iron	33-37	hemopexin	Homo sapiens	230-239
32585319-6	2020	Pharmacologic modulators of the BMP-SMAD pathway have shown efficacy in pre-clinical models to regulate hepcidin expression and treat iron-related disorders.	Iron	134-138	SMAD family member 1	Homo sapiens	36-40
31554244-5	2019	Heme toxicity, which may lead to iron toxicity, is recognized increasingly in a wide range of conditions involving hemolysis and immune system activation and, in this review, we highlight some newly identified actions of heme and hemopexin especially in situations where normal processes fail to maintain heme and iron homeostasis.	Iron	314-318	hemopexin	Homo sapiens	230-239
32585319-7	2020	This review will discuss recent insights into the role of the BMP-SMAD pathway in regulating hepcidin to control systemic iron homeostasis.	Iron	122-126	bone morphogenetic protein 2	Homo sapiens	62-65
32585319-7	2020	This review will discuss recent insights into the role of the BMP-SMAD pathway in regulating hepcidin to control systemic iron homeostasis.	Iron	122-126	SMAD family member 1	Homo sapiens	66-70
31541184-3	2019	Intracellular iron transport is regulated by transferrin receptor 1 (TfR1).	Iron	14-18	transferrin receptor	Mus musculus	45-67
32957294-3	2020	In the system of iron-carbon internal electrolysis coupled with persulfate, the iron-carbon internal electrolysis and persulfate had a significant mutual influence, exhibiting a wide range of pH in the treatment process.	Iron	17-21	phenylalanine hydroxylase	Homo sapiens	192-194
31541184-3	2019	Intracellular iron transport is regulated by transferrin receptor 1 (TfR1).	Iron	14-18	transferrin receptor	Mus musculus	69-73
31541184-9	2019	Level of intracellular iron transport protein, TfR1, was decreased in ischemic adductor muscles.	Iron	23-27	transferrin receptor	Mus musculus	47-51
32957294-3	2020	In the system of iron-carbon internal electrolysis coupled with persulfate, the iron-carbon internal electrolysis and persulfate had a significant mutual influence, exhibiting a wide range of pH in the treatment process.	Iron	80-84	phenylalanine hydroxylase	Homo sapiens	192-194
32588561-1	2020	BACKGROUND: Hepcidin and hemochromatosis (HFE) are iron regulatory proteins that are encoded by HAMP and HFE genes.	Iron	51-55	homeostatic iron regulator	Homo sapiens	42-45
31620456-1	2019	Neutrophil gelatinase-associated Lipocalin (NGAL) is a glycoprotein involved in inflammation acting as an acute phase protein and chemokine as well as a regulator of iron homeostasis.	Iron	166-170	lipocalin 2	Canis lupus familiaris	0-42
31620456-1	2019	Neutrophil gelatinase-associated Lipocalin (NGAL) is a glycoprotein involved in inflammation acting as an acute phase protein and chemokine as well as a regulator of iron homeostasis.	Iron	166-170	lipocalin 2	Canis lupus familiaris	44-48
32588561-1	2020	BACKGROUND: Hepcidin and hemochromatosis (HFE) are iron regulatory proteins that are encoded by HAMP and HFE genes.	Iron	51-55	homeostatic iron regulator	Homo sapiens	105-108
32588561-2	2020	Mutation in either HAMP gene or HFE gene causes Hepcidin protein deficiency that can lead to iron overload in beta thalassemia patients.	Iron	93-97	homeostatic iron regulator	Homo sapiens	32-35
32882878-6	2020	5% Co together with 2% Fe could also be promising, since they exhibited fewer diffusive limitations, mainly due to their peculiar pore distribution (by Brunauer-Emmett-Teller, BET) that disfavored the cathode clogging.	Iron	23-25	delta/notch like EGF repeat containing	Homo sapiens	176-179
31608084-0	2019	The Intracellular Transporter AtNRAMP6 Is Involved in Fe Homeostasis in Arabidopsis.	Iron	54-56	NRAMP metal ion transporter 6	Arabidopsis thaliana	30-38
31608084-4	2019	This study demonstrates that AtNRAMP6 is localized to the Golgi/trans-Golgi network and plays an important role in intracellular Fe homeostasis in the flowering plant genus Arabidopsis.	Iron	129-131	NRAMP metal ion transporter 6	Arabidopsis thaliana	29-37
31608084-7	2019	Lastly, the expression of AtNRAMP6 was found to exacerbate the sensitivity of the yeast mutant Deltaccc1 to an excessive amount of Fe.	Iron	131-133	NRAMP metal ion transporter 6	Arabidopsis thaliana	26-34
32831652-15	2020	In addition, iron increased the expression of Warburg key enzymes HK2 and Glut1, and affected AMPK/mTORC1 signaling axis.	Iron	13-17	hexokinase 2	Homo sapiens	66-69
31500291-6	2019	IRPs are considered the master regulators of intracellular iron homeostasis because they coordinate the expression of iron storage (ferritin) and iron uptake (transferrin receptor) genes.	Iron	59-63	transferrin receptor	Homo sapiens	159-179
31500291-7	2019	In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type.	Iron	26-30	Wnt family member 2	Homo sapiens	128-131
31500291-8	2019	However, all mutation types exhibited robust changes in ferritin and transferrin receptor protein expression in response to iron loading and iron chelation, respectively.	Iron	124-128	transferrin receptor	Homo sapiens	69-89
31500291-8	2019	However, all mutation types exhibited robust changes in ferritin and transferrin receptor protein expression in response to iron loading and iron chelation, respectively.	Iron	141-145	transferrin receptor	Homo sapiens	69-89
32831652-15	2020	In addition, iron increased the expression of Warburg key enzymes HK2 and Glut1, and affected AMPK/mTORC1 signaling axis.	Iron	13-17	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	94-98
31500291-9	2019	These findings suggest a novel, IRP-independent mode of iron regulation in cells expressing distinct TP53 mutations.	Iron	56-60	Wnt family member 2	Homo sapiens	32-35
31522215-0	2019	Association of frequency of hereditary hemochromatosis (HFE) gene mutations (H63D and C282Y) with iron overload in beta-thalassemia major patients in Pakistan.	Iron	98-102	homeostatic iron regulator	Homo sapiens	56-59
31522215-1	2019	OBJECTIVES: To evaluate any association between the frequency of hereditary hemochromatosis (HFE) gene mutation (H63D and C282Y) and iron overload in beta-thalassemia major (BTM) patients.	Iron	133-137	homeostatic iron regulator	Homo sapiens	93-96
32831652-15	2020	In addition, iron increased the expression of Warburg key enzymes HK2 and Glut1, and affected AMPK/mTORC1 signaling axis.	Iron	13-17	CREB regulated transcription coactivator 1	Mus musculus	99-105
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	leucine zipper transcription factor like 1	Sus scrofa	331-337
32769410-1	2021	BACKGROUND AND AIMS: Proton pump inhibitors (PPIs) may reduce iron absorption and serum ferritin levels in patients with homeostatic iron regulator (HFE)-related hemochromatosis, reducing the need for frequent phlebotomies.	Iron	133-137	homeostatic iron regulator	Homo sapiens	149-152
30765471-4	2019	In erythroid cells, loss of ABCB7 altered cellular iron distribution and caused mitochondrial iron overload due to activation of iron regulatory proteins 1 and 2 in the cytosol and to upregulation of the mitochondrial iron importer, mitoferrin-1.	Iron	94-98	aconitase 1	Homo sapiens	129-161
30765471-4	2019	In erythroid cells, loss of ABCB7 altered cellular iron distribution and caused mitochondrial iron overload due to activation of iron regulatory proteins 1 and 2 in the cytosol and to upregulation of the mitochondrial iron importer, mitoferrin-1.	Iron	94-98	aconitase 1	Homo sapiens	129-161
30765471-6	2019	In ABCB7-depleted cells, defective heme biosynthesis resulted from translational repression of ALAS2 by iron regulatory proteins and from decreased stability of the terminal enzyme ferrochelatase.	Iron	104-108	5'-aminolevulinate synthase 2	Homo sapiens	95-100
31522215-13	2019	Larger-scale research is required to give an elaborated view of the association of the HFE mutation with iron overload in these patients and to confirm our conclusion.	Iron	105-109	homeostatic iron regulator	Homo sapiens	87-90
31449551-3	2019	This includes the innate immune protein lipocalin 2 (Lcn2), which prevents Kp iron acquisition.	Iron	78-82	lipocalin 2	Mus musculus	53-57
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	129-133	Mga2p	Saccharomyces cerevisiae S288C	28-32
31409839-2	2019	The chimeric protein combines the versatility in 24-meric assembly and cargo incorporation capability of Archaeglobus fulgidus ferritin with specific binding of human H ferritin to CD71, the "heavy duty" carrier responsible for transferrin-iron uptake.	Iron	240-244	transferrin receptor	Homo sapiens	181-185
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	157-161	Mga2p	Saccharomyces cerevisiae S288C	28-32
31463593-6	2019	Our results reveal the asymmetric functional roles of the Dph1-Dph2 heterodimer and may help to understand how the Fe-S clusters in radical SAM enzymes are reduced in biology.	Iron	115-119	diphthamide biosynthesis 2	Homo sapiens	63-67
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	157-161	Mga2p	Saccharomyces cerevisiae S288C	28-32
32448579-1	2020	Lactoferrin (LF), a sialylated iron-binding glycoprotein, has numerous vital physiological functions including immunomodulation and protection against a large group of microorganisms, improving neurodevelopment, health, growth performance, and milk production.	Iron	31-35	lactotransferrin	Sus scrofa	0-11
30474149-0	2019	31 P NMR assessment of the phosvitin-iron complex in mayonnaise.	Iron	37-41	casein kinase 2 beta	Homo sapiens	27-36
30474149-2	2019	One of the main catalysts of this process is iron, which is introduced in its ferric (Fe(III)) form via phosvitin, an egg yolk phosphoprotein rich in phosphoserines.	Iron	45-49	casein kinase 2 beta	Homo sapiens	104-113
30655378-6	2019	In KCNN4-related disease, the main symptoms were more severe anemia, hemolysis and iron overload, with no clear sign of red cell dehydration; therefore, this disorder would be better described as a "Gardos channelopathy".	Iron	83-87	potassium calcium-activated channel subfamily N member 4	Homo sapiens	3-8
32619040-10	2020	Whilst lack of EIN3 reduces seed Fe content, overexpression of ERF95 rescues Fe accumulation in the seed of ein3 loss-of-function mutant.	Iron	77-79	Ethylene insensitive 3 family protein	Arabidopsis thaliana	108-112
30927265-5	2019	As exhibited, we observed that CD68 was significant enriched by high iron diet in apoE-deficient mice.	Iron	69-73	CD68 antigen	Mus musculus	31-35
30927265-6	2019	In addition, transforming growth factor beta, tumor necrosis factor alpha, interleukin 6 (IL-6), IL-23, IL-10, and IL-1beta levels were also greatly induced by high iron diet.	Iron	165-169	interleukin 23, alpha subunit p19	Mus musculus	97-102
31237488-14	2019	By IHC, SOX9- and Coll2A1-positive cells were detected in the same regions as the detected cells/iron deposits.	Iron	97-101	SRY-box transcription factor 9	Homo sapiens	8-12
32579652-6	2020	Compared with the parent NiCo-MOF HNSs, the optimized Fe@NiCo-MOF HNSs exhibited a lower overpotential of 244 mV at 10 mA cm-2 with a smaller Tafel slope of 48.61 mV dec-1, which was lowered by ca.	Iron	54-56	deleted in esophageal cancer 1	Homo sapiens	166-171
31551905-7	2019	Work in C. elegans showed a link between the MEIS1 ortholog and iron homeostasis, which is in line with the fact that central nervous system (CNS) iron insufficiency is thought to be a cause of RLS.	Iron	64-68	Meis homeobox 1	Mus musculus	45-50
31551905-7	2019	Work in C. elegans showed a link between the MEIS1 ortholog and iron homeostasis, which is in line with the fact that central nervous system (CNS) iron insufficiency is thought to be a cause of RLS.	Iron	147-151	Meis homeobox 1	Mus musculus	45-50
31551905-12	2019	The links to iron and the enhancer activity of the HCNRs of MEIS1 suggest promising links to RLS pathways, however more in-depth studies on this gene"s function are required.	Iron	13-17	Meis homeobox 1	Mus musculus	60-65
31423010-6	2019	The cellular iron concentration regulated the expression of the iron-regulatory protein (IRP) via the 5"-untranslated region of IRP messenger RNA and modulated the post-transcriptional stability of FPN1.	Iron	13-17	Wnt family member 2	Homo sapiens	64-87
31035133-2	2019	The microstructure, surface charge and the formation mechanism of iron-based silica binary aerogels are analyzed by SEM, zeta potential and BET.	Iron	66-70	delta/notch like EGF repeat containing	Homo sapiens	140-143
31150776-2	2019	Unlike other iron-sulfur clusters in proteins, the reduced CDGSH-type [2Fe-2S] clusters in Miner2 are able to bind nitric oxide (NO) and form stable NO-bound [2Fe-2S] clusters without disruption of the clusters.	Iron	13-17	CDGSH iron sulfur domain 3	Homo sapiens	91-97
31002437-0	2019	Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist.	Iron	122-126	ATP binding cassette subfamily B member 5	Homo sapiens	14-55
31423010-6	2019	The cellular iron concentration regulated the expression of the iron-regulatory protein (IRP) via the 5"-untranslated region of IRP messenger RNA and modulated the post-transcriptional stability of FPN1.	Iron	13-17	Wnt family member 2	Homo sapiens	89-92
31423010-6	2019	The cellular iron concentration regulated the expression of the iron-regulatory protein (IRP) via the 5"-untranslated region of IRP messenger RNA and modulated the post-transcriptional stability of FPN1.	Iron	13-17	Wnt family member 2	Homo sapiens	128-131
32645006-7	2020	LAVE was effective in optimizing RIs for AST, ALT, GGT iron-markers and CRP by reducing influence of latent anemia and metabolic diseases.	Iron	55-59	gamma-glutamyltransferase light chain 5 pseudogene	Homo sapiens	51-54
31190424-5	2019	Consequently, Ni-doped Fe3 O4 clusters are revealed as a superior OER catalyst with a small overpotential of 272 mV at 10 mA cm-2 and a small Tafel slope of 39.4 mV dec-1 , surpassing almost all spinel Fe-based OER catalysts.	Iron	23-25	deleted in esophageal cancer 1	Homo sapiens	165-170
31667458-2	2019	Both HFE patients and Hfe-mouse models develop a progressive accumulation of iron in the parenchymal cells of various tissues, eventually resulting in liver cirrhosis, hepatocellular carcinoma, cardiomyopathies, hypogonadism, and other pathologies.	Iron	77-81	homeostatic iron regulator	Homo sapiens	5-8
31667458-2	2019	Both HFE patients and Hfe-mouse models develop a progressive accumulation of iron in the parenchymal cells of various tissues, eventually resulting in liver cirrhosis, hepatocellular carcinoma, cardiomyopathies, hypogonadism, and other pathologies.	Iron	77-81	homeostatic iron regulator	Homo sapiens	22-25
31622736-1	2020	BACKGROUND &amp; AIMS: Fibrosis stage can decrease following treatment in patients with hemochromatosis caused by mutations in the homeostatic iron regulator gene (HFE), but the effects on cirrhosis are not clear.	Iron	143-147	homeostatic iron regulator	Homo sapiens	164-167
31229404-5	2019	Together, these data identify a novel oxygen-dependent signaling axis that links IRP-dependent iron homeostasis with the Fe-S cluster assembly machinery.	Iron	95-99	Wnt family member 2	Homo sapiens	81-84
31229404-5	2019	Together, these data identify a novel oxygen-dependent signaling axis that links IRP-dependent iron homeostasis with the Fe-S cluster assembly machinery.	Iron	121-125	Wnt family member 2	Homo sapiens	81-84
31395877-4	2019	By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters.	Iron	195-197	NFS1 cysteine desulfurase	Homo sapiens	62-66
32129080-6	2020	The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2.	Iron	170-174	transferrin receptor	Mus musculus	26-30
32129080-6	2020	The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2.	Iron	170-174	wingless-type MMTV integration site family, member 2	Mus musculus	166-169
31088840-2	2019	Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor"s responses to changes in oxygen, iron, nutrient, or energy levels.	Iron	144-148	transcription factor binding to IGHM enhancer 3	Homo sapiens	68-72
31245986-0	2019	MOF-Derived Isolated Fe Atoms Implanted in N-Doped 3D Hierarchical Carbon as an Efficient ORR Electrocatalyst in Both Alkaline and Acidic Media.	Iron	21-23	lysine acetyltransferase 8	Homo sapiens	0-3
32487561-12	2020	CD4+ T cells showed no intrinsic difference in proliferation and polarization in vitro, whereas iron siderophore-loaded NGAL suppressed TH17 polarization.	Iron	96-100	lipocalin 2	Mus musculus	120-124
31260277-7	2019	Strongly polarized Fe-C bonds are observed where the negative charge is mostly centered at the mu2-C yldiide ligands.	Iron	19-21	adaptor related protein complex 1 subunit mu 2	Homo sapiens	95-98
31447555-5	2019	NAC can effectively mitigate iron-induced oxidative injury of cardiomyocytes, evidenced by reduced production of MDA, 8-iso-PGF2alpha, and 8-OHDG and maintained concentrations of SOD, CAT, GSH-Px, and GSH in ELISA and biochemical tests; downregulated expression of CHOP, GRP78, p62, and LC3-II proteins in Western Blot, and less cardiomyocytes apoptosis in flow cytometric analysis.	Iron	29-33	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	278-281
32304700-5	2020	Here, we describe the identification, maturation, characterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a native receptor and BBB transporter for the iron chaperone transferrin.	Iron	185-189	transferrin receptor	Mus musculus	111-131
30968973-9	2019	The increased transferrin receptor and decreased L-ferritin levels after hypobaric hypoxia were indicative of a low-iron phenotype, while FPN1 levels remained unchanged.	Iron	116-120	transferrin receptor	Rattus norvegicus	14-34
32304700-5	2020	Here, we describe the identification, maturation, characterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a native receptor and BBB transporter for the iron chaperone transferrin.	Iron	185-189	transferrin receptor	Mus musculus	133-136
31354776-9	2019	Moreover, the leaf Fe status-dependent shoot-to-root signaling mutant opt3-2, which is impaired in the phloem-specific Fe transporter OPT3, still up-regulated the Fe deficiency response genes MYB72 and IRT1 in response to WCS417.	Iron	19-21	oligopeptide transporter	Arabidopsis thaliana	70-74
32366593-1	2020	The bacterial bipartite transferrin receptor is an iron acquisition system that several important human and animal pathogens require for survival.	Iron	51-55	transferrin receptor	Homo sapiens	24-44
31354776-9	2019	Moreover, the leaf Fe status-dependent shoot-to-root signaling mutant opt3-2, which is impaired in the phloem-specific Fe transporter OPT3, still up-regulated the Fe deficiency response genes MYB72 and IRT1 in response to WCS417.	Iron	19-21	oligopeptide transporter	Arabidopsis thaliana	134-138
30773647-0	2019	Transcriptional integration of the responses to iron availability in Arabidopsis by the bHLH factor ILR3.	Iron	48-52	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	100-104
30773647-5	2019	A transcriptional activator of responses to Fe shortage in Arabidopsis, called bHLH105/ILR3, was found to also negatively regulate the expression of ferritin genes, which are markers of the plant"s response to Fe excess.	Iron	44-46	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	79-86
32560750-1	2020	Iron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations.	Iron	0-4	viral integration site 1	Homo sapiens	50-55
30773647-5	2019	A transcriptional activator of responses to Fe shortage in Arabidopsis, called bHLH105/ILR3, was found to also negatively regulate the expression of ferritin genes, which are markers of the plant"s response to Fe excess.	Iron	44-46	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	87-91
30773647-5	2019	A transcriptional activator of responses to Fe shortage in Arabidopsis, called bHLH105/ILR3, was found to also negatively regulate the expression of ferritin genes, which are markers of the plant"s response to Fe excess.	Iron	210-212	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	79-86
30773647-5	2019	A transcriptional activator of responses to Fe shortage in Arabidopsis, called bHLH105/ILR3, was found to also negatively regulate the expression of ferritin genes, which are markers of the plant"s response to Fe excess.	Iron	210-212	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	87-91
30773647-6	2019	Further investigations revealed that ILR3 repressed the expression of several structural genes that function in the control of Fe homeostasis.	Iron	127-129	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	37-41
30773647-9	2019	Altogether, the data presented herein support that ILR3 is at the centre of the transcriptional regulatory network that controls Fe homeostasis in Arabidopsis, in which it acts as both transcriptional activator and repressor.	Iron	129-131	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	51-55
31332290-1	2019	p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2).	Iron	82-86	ferredoxin reductase	Mus musculus	68-72
31332290-3	2019	In this study, we found that FDXR deficiency decreased mutant p53 expression along with altered iron metabolism in p53R270H/- MEFs and cancer cells carrying mutant p53.	Iron	96-100	ferredoxin reductase	Mus musculus	29-33
31292266-0	2019	A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.	Iron	34-38	splicing factor 3b subunit 1	Homo sapiens	54-59
31292266-2	2019	Patients with MDS with SF3B1 mutations often accumulate excessive tissue iron, even in the absence of transfusions, but the mechanisms that are responsible for their parenchymal iron overload are unknown.	Iron	73-77	splicing factor 3b subunit 1	Homo sapiens	23-28
31292266-2	2019	Patients with MDS with SF3B1 mutations often accumulate excessive tissue iron, even in the absence of transfusions, but the mechanisms that are responsible for their parenchymal iron overload are unknown.	Iron	178-182	splicing factor 3b subunit 1	Homo sapiens	23-28
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	85-89	splicing factor 3b subunit 1	Homo sapiens	115-120
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	184-188	splicing factor 3b subunit 1	Homo sapiens	115-120
30968138-3	2019	It has been suggested that both the non-catalytic C-terminal domain of Pol2 (with the two cysteine motifs CysA and CysB) and Pol2CORE (with the CysX cysteine motif) are likely to coordinate an Fe-S cluster.	Iron	193-197	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	71-75
30968138-3	2019	It has been suggested that both the non-catalytic C-terminal domain of Pol2 (with the two cysteine motifs CysA and CysB) and Pol2CORE (with the CysX cysteine motif) are likely to coordinate an Fe-S cluster.	Iron	193-197	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	125-133
30968138-4	2019	Here, we present two new crystal structures of Pol2CORE with an Fe-S cluster bound to the CysX motif, supported by an anomalous signal at that position.	Iron	64-68	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	47-55
31229404-1	2019	The iron-sensing protein FBXL5 is the substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradation of iron regulatory proteins (IRPs).	Iron	4-8	cullin 1	Homo sapiens	67-71
32685019-7	2020	GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin).	Iron	85-89	transferrin receptor	Mus musculus	191-211
31396093-9	2019	Glomerular area, interstitial fibrosis, tubular iron deposits, and KIM-1 protein expression were significantly reduced after RAP treatment.	Iron	48-52	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	125-128
31074996-6	2019	The electronic structure modulation combined with electrochemical topotactic transformation strategies well stimulate the reactive Fe sites in Ni-FeS2-0.5, which show impressively low overpotentials of 250 and 326 mV to drive the current densities ( j) of 10 and 100 mA cm-2, respectively, and a Tafel slope as small as 34 mV dec-1 for the OER process.	Iron	131-133	deleted in esophageal cancer 1	Homo sapiens	326-331
32685019-7	2020	GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin).	Iron	85-89	transferrin receptor	Mus musculus	191-211
32685019-7	2020	GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin).	Iron	85-89	transferrin receptor	Mus musculus	191-211
31159500-1	2019	The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis.	Iron	172-176	atonal bHLH transcription factor 8	Mus musculus	55-60
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	37-41	ataxia telangiectasia mutated	Mus musculus	0-3
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	37-41	transferrin receptor	Mus musculus	102-106
31159500-1	2019	The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis.	Iron	172-176	atonal bHLH transcription factor 8	Mus musculus	62-78
32515736-5	2020	We identified the iron-regulated ECF-transporter Lha in the opportunistic bacterial pathogen Staphylococcus lugdunensis and show that the transporter is specific for heme.	Iron	18-22	glycoprotein hormones, alpha polypeptide	Homo sapiens	49-52
31159500-1	2019	The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis.	Iron	172-176	atonal bHLH transcription factor 8	Mus musculus	80-85
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	166-170	ataxia telangiectasia mutated	Mus musculus	0-3
31268713-4	2019	Predicted structural differences upon deprotonation of MCp2, M = Fe and Mg, are also in accord with this view.	Iron	65-67	C-C motif chemokine ligand 8	Homo sapiens	55-59
31011852-0	2019	Safe coordinated trafficking of heme and iron with copper maintain cell homeostasis: modules from the hemopexin system.	Iron	41-45	hemopexin	Homo sapiens	102-111
31011852-3	2019	Heme-hemopexin endocytosis leads to coordinated trafficking of heme, iron and copper as heme traffics from endosomes to heme oxygenases (HOs) in the smooth endoplasmic reticulum and to the nucleus.	Iron	69-73	hemopexin	Homo sapiens	5-14
32515736-7	2020	Using isogenic mutants and recombinant expression of Lha, we demonstrate that its function is independent of the canonical heme acquisition system Isd and allows proliferation on human cells as sources of nutrient iron.	Iron	214-218	glycoprotein hormones, alpha polypeptide	Homo sapiens	53-56
32499495-6	2020	Molecular analysis indicates that FDXR mutation also leads to mitochondrial iron overload and an associated depolarization of the mitochondrial membrane, further supporting the hypothesis that FDXR mutations cause neurodegeneration by affecting FDXR"s critical role in iron homeostasis.	Iron	76-80	ferredoxin reductase	Homo sapiens	34-38
31213851-11	2019	Conclusion: We demonstrated that DFO could upregulate expression of TfR1 and DMT1 , which enhanced iron uptake via activating IL-6/PI3K/AKT signaling pathway in aggressive TNBCs.	Iron	99-103	transferrin receptor	Homo sapiens	68-72
31233037-4	2019	A western blot analysis showed that an iron/fat-enriched diet triggered testicular endoplasmic reticular (ER) stress but decreased mitochondrion biogenesis proteins (PGC1alpha and TFAM) and T-converting proteins (StAR, CYP11A, and 17beta-HSD).	Iron	39-43	transcription factor A, mitochondrial	Rattus norvegicus	180-184
32499495-6	2020	Molecular analysis indicates that FDXR mutation also leads to mitochondrial iron overload and an associated depolarization of the mitochondrial membrane, further supporting the hypothesis that FDXR mutations cause neurodegeneration by affecting FDXR"s critical role in iron homeostasis.	Iron	76-80	ferredoxin reductase	Homo sapiens	193-197
31031004-2	2019	FXN participates in the biosynthesis of Fe-S clusters and is considered to be essential for viability.	Iron	40-44	frataxin	Homo sapiens	0-3
32499495-6	2020	Molecular analysis indicates that FDXR mutation also leads to mitochondrial iron overload and an associated depolarization of the mitochondrial membrane, further supporting the hypothesis that FDXR mutations cause neurodegeneration by affecting FDXR"s critical role in iron homeostasis.	Iron	76-80	ferredoxin reductase	Homo sapiens	193-197
32499495-6	2020	Molecular analysis indicates that FDXR mutation also leads to mitochondrial iron overload and an associated depolarization of the mitochondrial membrane, further supporting the hypothesis that FDXR mutations cause neurodegeneration by affecting FDXR"s critical role in iron homeostasis.	Iron	269-273	ferredoxin reductase	Homo sapiens	34-38
31067022-0	2019	Enhanced CH4 and CO Oxidation over Ce1- xFe xO2-delta Hybrid Catalysts by Tuning the Lattice Distortion and the State of Surface Iron Species.	Iron	129-133	carboxylesterase 1	Homo sapiens	35-38
32499495-6	2020	Molecular analysis indicates that FDXR mutation also leads to mitochondrial iron overload and an associated depolarization of the mitochondrial membrane, further supporting the hypothesis that FDXR mutations cause neurodegeneration by affecting FDXR"s critical role in iron homeostasis.	Iron	269-273	ferredoxin reductase	Homo sapiens	193-197
32499495-6	2020	Molecular analysis indicates that FDXR mutation also leads to mitochondrial iron overload and an associated depolarization of the mitochondrial membrane, further supporting the hypothesis that FDXR mutations cause neurodegeneration by affecting FDXR"s critical role in iron homeostasis.	Iron	269-273	ferredoxin reductase	Homo sapiens	193-197
33479694-4	2020	Isothermal titration calorimetry, competition with calcein, induced precipitation of radioactive iron and cross inhibition of the unrelated iron transporter SLC39A8 (hZIP8) indicate that inhibition is mediated by metal chelation.	Iron	140-144	solute carrier family 39 member 8	Homo sapiens	157-164
31211210-0	2019	Physiological and RNA sequencing data of white lupin plants grown under Fe and P deficiency.	Iron	72-74	5'-nucleotidase, cytosolic IIIA	Homo sapiens	47-52
31211210-1	2019	This DIB article provides details about transcriptional and physiological response of Fe- and P-deficient white lupin roots, an extensive and complete description of plant response is shown in the research article "Physiological and transcriptomic data highlight common features between iron and phosphorus acquisition mechanisms in white lupin roots" Venuti et al.	Iron	86-88	5'-nucleotidase, cytosolic IIIA	Homo sapiens	112-117
31211210-1	2019	This DIB article provides details about transcriptional and physiological response of Fe- and P-deficient white lupin roots, an extensive and complete description of plant response is shown in the research article "Physiological and transcriptomic data highlight common features between iron and phosphorus acquisition mechanisms in white lupin roots" Venuti et al.	Iron	287-291	5'-nucleotidase, cytosolic IIIA	Homo sapiens	112-117
31211210-1	2019	This DIB article provides details about transcriptional and physiological response of Fe- and P-deficient white lupin roots, an extensive and complete description of plant response is shown in the research article "Physiological and transcriptomic data highlight common features between iron and phosphorus acquisition mechanisms in white lupin roots" Venuti et al.	Iron	287-291	5'-nucleotidase, cytosolic IIIA	Homo sapiens	339-344
31211210-5	2019	Moreover, the transcriptomic changes occurring in apices and clusters of Fe-deficient lupin roots were investigated and compared with differences of gene expression occurring in P-deficient plants (-P) and in Fe- and P-sufficient plants (+P + Fe).	Iron	73-75	5'-nucleotidase, cytosolic IIIA	Homo sapiens	86-91
33479694-4	2020	Isothermal titration calorimetry, competition with calcein, induced precipitation of radioactive iron and cross inhibition of the unrelated iron transporter SLC39A8 (hZIP8) indicate that inhibition is mediated by metal chelation.	Iron	140-144	solute carrier family 39 member 8	Homo sapiens	166-171
32209423-7	2020	There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice.	Iron	25-29	transferrin receptor	Mus musculus	100-122
31017164-2	2019	In this study, three-dimensional (3D) freestanding multi-doped hollow carbon spheres (N-Co-Fe-HCS) with a layer thickness of 30 nm, which contained multiple active sites of the heteroatom N and transition metals (Co and Fe), were synthesized via a simple template method (with SiO2 as the template) and cost-efficient in situ self-polymerization, self-adsorption/reduction and carbonization strategies.	Iron	91-93	holocarboxylase synthetase	Homo sapiens	94-97
32209423-7	2020	There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice.	Iron	25-29	transferrin receptor	Mus musculus	124-128
32209423-8	2020	Decreased levels of TfR1 and FTL proteins observed in HuA treated CIH group, could reduce iron overload in hippocampus.	Iron	90-94	transferrin receptor	Mus musculus	20-24
31143190-9	2019	Similar to findings in fetal microglia, in fetal astrocytes we observed a memory effect of in vivo exposure to inflammation, expressed in a perturbation of the iron homeostasis signaling pathway (hemoxygenase 1, HMOX1), which persisted under pre-treatment with alpha7nAChR antagonist but was reversed with alpha7nAChR agonist.	Iron	160-164	heme oxygenase 1	Ovis aries	212-217
32494128-0	2020	Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women.	Iron	42-46	homeostatic iron regulator	Homo sapiens	10-13
30409066-4	2019	We found that there was a significant difference between SF3B1-mutant and SF3B1-wild-type MDS patients in intracellular iron III, intracellular iron IV and ring sideroblasts.	Iron	120-124	splicing factor 3b subunit 1	Homo sapiens	74-79
30409066-6	2019	We suggest that the patients carrying SF3B1 mutation with Iron score >=10 will extend the subtype of MDS-RS, in addition to the current WHO classification criteria.	Iron	58-62	splicing factor 3b subunit 1	Homo sapiens	38-43
30409066-7	2019	This study gives us a new insight into the relation of SF3B1 mutation and intracellular iron in lower-risk MDS.	Iron	88-92	splicing factor 3b subunit 1	Homo sapiens	55-60
32494128-4	2020	Here, we evaluated changes in iron metabolism induced by exercise in elderly women bearing the H63A HFE mutation.	Iron	30-34	homeostatic iron regulator	Homo sapiens	100-103
32321351-0	2020	Iron Metabolism Contributes to Prognosis in Coronary Artery Disease: Prognostic Value of the Soluble Transferrin Receptor Within the AtheroGene Study.	Iron	0-4	transferrin receptor	Homo sapiens	101-121
31218272-0	2019	Salivary Cystatin SN Binds to Phytic Acid In Vitro and Is a Predictor of Nonheme Iron Bioavailability with Phytic Acid Supplementation in a Proof of Concept Pilot Study.	Iron	81-85	cystatin SN	Homo sapiens	9-20
31218272-9	2019	Basic PRPs and cystatin SN concentrations were positively correlated with iron bioavailability at week 4.	Iron	74-78	cystatin SN	Homo sapiens	15-26
32432042-3	2020	Here, we demonstrate that the alteration of iron homeostasis and the consequent increase of redox metabolism, mediated by the stable knock down of ferritin heavy chain (FtH), enhances the expression of CXCR4 in K562 erythroleukemia cells, thus promoting CXCL12-mediated motility.	Iron	44-48	C-X-C motif chemokine ligand 12	Homo sapiens	254-260
30339210-0	2019	Iron Overload in an HFE Heterozygous Carrier: A Case Report and Literature Review.	Iron	0-4	homeostatic iron regulator	Homo sapiens	20-23
30339210-3	2019	These mutations cause alterations in HFE membrane expression, structure, and/or activity, leading to dysregulation of iron absorption.	Iron	118-122	homeostatic iron regulator	Homo sapiens	37-40
32432042-11	2020	The effects of FtH dysregulation on CXCR4/CXCL12-mediated K562 cell motility extend the meaning of iron homeostasis in the leukemia cell microenvironment.	Iron	99-103	C-X-C motif chemokine ligand 12	Homo sapiens	42-48
31309445-8	2020	The expression and activity of glucose 6-phosphate dehydrogenase (G6pd), glutathione reductase (Gr), glutathione peroxidase (Gpx), and glutathione S-transferases (Gst) were significantly affected by the presence of iron.	Iron	215-219	glucose-6-phosphate dehydrogenase	Rattus norvegicus	31-64
31105999-6	2019	Knockdown of HMGB1 decreased erastin-induced ROS generation and cell death in an iron-mediated lysosomal pathway in HL-60/NRASQ61L cells.	Iron	81-85	high mobility group box 1	Homo sapiens	13-18
32296847-8	2020	Thus, these findings indicate that iron-binding protein LCN2-mediated oxidative stress promotes neurodegeneration in ob/ob mice.	Iron	35-39	lipocalin 2	Mus musculus	56-60
30506348-8	2019	It was noted that individuals homozygous or heterozygous for the effect allele in the BCL11A and HMIP SNPs had higher HbF levels, lower ferritin concentrations, and lower liver iron content and were less likely to be transfusion dependent.	Iron	177-181	BAF chromatin remodeling complex subunit BCL11A	Homo sapiens	86-92
32143980-3	2020	Two of these studies suggest that an epistatic interaction between variants rs1049296 in the transferrin (TF) gene and rs1800562 in the homeostatic iron regulator (HFE) gene, commonly known as hemochromatosis, is in genetic association with AD.	Iron	148-152	homeostatic iron regulator	Homo sapiens	164-167
30874991-2	2019	Insufficient frataxin levels leads to iron and copper deposits in the brain and cardiac cells.	Iron	38-42	frataxin	Homo sapiens	13-21
30874991-8	2019	This can be of importance in understanding the pathophysiology of the disease in association with frataxin/iron.	Iron	107-111	frataxin	Homo sapiens	98-106
32143980-4	2020	TF and HFE are involved in the transport and regulation of iron in the brain, and disrupting these processes exacerbates AD pathology through increased neurodegeneration and oxidative stress.	Iron	59-63	homeostatic iron regulator	Homo sapiens	7-10
32169822-4	2020	In the present study, we demonstrate that the protein Frataxin (FXN) is a key regulator of ferroptosis by modulating iron homeostasis and mitochondrial function.	Iron	117-121	frataxin	Homo sapiens	54-62
30731113-0	2019	Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy.	Iron	67-71	sideroflexin 1	Mus musculus	30-43
30731113-2	2019	In the present study, we aim to investigate the role of NCOA4-mediated ferritinophagy and SFXN1-dependent mitochondria iron overload in apelin-13-induced cardiomyocytes hypertrophy.	Iron	119-123	sideroflexin 1	Mus musculus	90-95
30731113-4	2019	Mechanistically, apelin-13 effectively induces the expression of SFXN1, a mitochondria iron transporting protein and NCOA4, a cargo receptor of ferritinophagy in dose and time-dependent manner.	Iron	87-91	sideroflexin 1	Mus musculus	65-70
32169822-4	2020	In the present study, we demonstrate that the protein Frataxin (FXN) is a key regulator of ferroptosis by modulating iron homeostasis and mitochondrial function.	Iron	117-121	frataxin	Homo sapiens	64-67
30731113-6	2019	In addition, apelin-13-triggered mitochondria iron overload is reversed by the genetic inhibition of SFXN1 and NCOA4.	Iron	46-50	sideroflexin 1	Mus musculus	101-106
30731113-6	2019	In addition, apelin-13-triggered mitochondria iron overload is reversed by the genetic inhibition of SFXN1 and NCOA4.	Iron	46-50	nuclear receptor coactivator 4	Mus musculus	111-116
32169822-5	2020	Suppression of FXN expression specifically repressed the proliferation, destroyed mitochondrial morphology, impeded Fe-S cluster assembly and activated iron starvation stress.	Iron	116-120	frataxin	Homo sapiens	15-18
30731113-10	2019	Taken together, these results provide experimental evidences that NCOA4-mediated ferritinophagy might be defined as an essential mechanism leading to apelin-13-cardiomyocytes hypertrophy in SFXN1-dependent mitochondria iron overload manners.	Iron	219-223	nuclear receptor coactivator 4	Mus musculus	66-71
30731113-10	2019	Taken together, these results provide experimental evidences that NCOA4-mediated ferritinophagy might be defined as an essential mechanism leading to apelin-13-cardiomyocytes hypertrophy in SFXN1-dependent mitochondria iron overload manners.	Iron	219-223	sideroflexin 1	Mus musculus	190-195
32169822-5	2020	Suppression of FXN expression specifically repressed the proliferation, destroyed mitochondrial morphology, impeded Fe-S cluster assembly and activated iron starvation stress.	Iron	152-156	frataxin	Homo sapiens	15-18
32169822-6	2020	Moreover, suppression of FXN expression significantly enhanced erastin-induced cell death through accelerating free iron accumulation, lipid peroxidation and resulted in dramatic mitochondria morphological damage including enhanced fragmentation and vanished cristae.	Iron	116-120	frataxin	Homo sapiens	25-28
30877170-0	2019	Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.	Iron	38-42	F-box and leucine-rich repeat protein 5	Mus musculus	14-19
30877170-2	2019	We now show that the iron-sensing ubiquitin ligase FBXL5 is a previously unrecognized oncosuppressor in liver carcinogenesis in mice.	Iron	21-25	F-box and leucine-rich repeat protein 5	Mus musculus	51-56
32169822-8	2020	Vice versa, enforced expression of FXN blocked iron starvation response and erastin-induced ferroptosis.	Iron	47-51	frataxin	Homo sapiens	35-38
30877170-3	2019	Hepatocellular iron overload elicited by FBXL5 ablation gave rise to oxidative stress, tissue damage, inflammation, and compensatory proliferation of hepatocytes and to consequent promotion of liver carcinogenesis induced by exposure to a chemical carcinogen.	Iron	15-19	F-box and leucine-rich repeat protein 5	Mus musculus	41-46
30877170-5	2019	FBXL5-deficient mice thus constitute the first genetically engineered mouse model of liver carcinogenesis promoted by iron overload.	Iron	118-122	F-box and leucine-rich repeat protein 5	Mus musculus	0-5
32169822-9	2020	More importantly, pharmacological or genetic blocking the signal of iron starvation could completely restore the resistance to ferroptosis in FXN knockdown cells and xenograft graft in vivo.	Iron	68-72	frataxin	Homo sapiens	142-145
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	140-144	homeostatic iron regulator	Homo sapiens	13-16
30886060-2	2019	(https://doi.org/10.1084/jem.20180900) generate a novel mouse model of liver cancer induced by iron overload by deleting the iron-sensing ubiquitin ligase FBXL5 specifically in hepatocytes and exposure to a chemical carcinogen.	Iron	95-99	F-box and leucine-rich repeat protein 5	Mus musculus	155-160
30886060-2	2019	(https://doi.org/10.1084/jem.20180900) generate a novel mouse model of liver cancer induced by iron overload by deleting the iron-sensing ubiquitin ligase FBXL5 specifically in hepatocytes and exposure to a chemical carcinogen.	Iron	125-129	F-box and leucine-rich repeat protein 5	Mus musculus	155-160
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	homeostatic iron regulator	Homo sapiens	13-16
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	homeostatic iron regulator	Homo sapiens	13-16
30998180-0	2019	[Analysis of HFE and Non-HFE Mutations in a Tibet Cohort with Iron Overload].	Iron	62-66	homeostatic iron regulator	Homo sapiens	13-16
32214052-6	2020	Mutations in HFE gene alter iron homeostasis leading to hereditary hemochromatosis and to an increased cancer risk because the accumulation of iron induces oxidative DNA damage and free radical activity.	Iron	28-32	homeostatic iron regulator	Homo sapiens	13-16
30998180-0	2019	[Analysis of HFE and Non-HFE Mutations in a Tibet Cohort with Iron Overload].	Iron	62-66	homeostatic iron regulator	Homo sapiens	25-28
32214052-6	2020	Mutations in HFE gene alter iron homeostasis leading to hereditary hemochromatosis and to an increased cancer risk because the accumulation of iron induces oxidative DNA damage and free radical activity.	Iron	143-147	homeostatic iron regulator	Homo sapiens	13-16
32258826-1	2020	Purpose: To report a case of bull"s eye maculopathy, a novel finding in a patient with iron overload secondary to hereditary hemochromatosis with a homozygous mutation of the HFE gene.	Iron	87-91	homeostatic iron regulator	Homo sapiens	175-178
30913256-1	2019	Homozygosity for the p.C282Y substitution in the HFE protein encoded by the hemochromatosis gene on chromosome 6p (HFE) is a common genetic trait that increases susceptibility to iron overload.	Iron	179-183	homeostatic iron regulator	Homo sapiens	49-52
30913256-1	2019	Homozygosity for the p.C282Y substitution in the HFE protein encoded by the hemochromatosis gene on chromosome 6p (HFE) is a common genetic trait that increases susceptibility to iron overload.	Iron	179-183	homeostatic iron regulator	Homo sapiens	115-118
31970519-2	2020	Previous studies have suggested that the G allele of C/G rare variant (rs1799945), which causes H63D amino acid replacement, in the HFE is associated with elevated iron indexes and may give some advantage in endurance-oriented sports.	Iron	164-168	homeostatic iron regulator	Homo sapiens	132-135
30778428-1	2019	Mitochondria iron overload is a key feature of the neurodegenerative disease Friedreich"s ataxia (FRDA).	Iron	13-17	frataxin	Homo sapiens	98-102
30778428-4	2019	Pre-treatment of the FRDA cells with a bespoke mitochondrial iron chelator fully abrogates the UVA-mediated cell death and reduces UVA-induced damage to mitochondrial membrane and the resulting ATP depletion by a factor of 2.	Iron	61-65	frataxin	Homo sapiens	21-25
30778428-5	2019	Our results reveal a link between FRDA as a disease of mitochondrial iron overload and sensitivity to UVA of skin fibroblasts.	Iron	69-73	frataxin	Homo sapiens	34-38
32189932-2	2020	The homeostatic iron regulator (HFE) gene C282Y mutation, a common cause for hemochromatosis in Europe, is considered almost nonexistent in India.	Iron	16-20	homeostatic iron regulator	Homo sapiens	32-35
30647129-10	2019	We conclude that a ferroportin-targeting sequence, (K/R)EWEE, present in APP and APLP2, but not APLP1, helps modulate Fpn-dependent iron efflux in the presence of an active multicopper ferroxidase.	Iron	132-136	amyloid beta precursor like protein 2	Homo sapiens	81-86
30874600-6	2019	Western blotting for LC3-I, LC3-II and P62 levels as well as immunofluorescent co-detection of autophagosomes with Cyto-ID and lysosomal cathepsin activity indicated that iron attenuated autophagic flux without altering total expression of Atg7 or beclin-1 and phosphorylation of mTORC1 and ULK1.	Iron	171-175	beclin 1	Rattus norvegicus	248-256
30874600-6	2019	Western blotting for LC3-I, LC3-II and P62 levels as well as immunofluorescent co-detection of autophagosomes with Cyto-ID and lysosomal cathepsin activity indicated that iron attenuated autophagic flux without altering total expression of Atg7 or beclin-1 and phosphorylation of mTORC1 and ULK1.	Iron	171-175	CREB regulated transcription coactivator 1	Mus musculus	280-286
30874615-0	2019	Copper transporter COPT5 participates in the crosstalk between vacuolar copper and iron pools mobilisation.	Iron	83-87	copper transporter 5	Arabidopsis thaliana	19-24
30871254-4	2019	Lipocalin-2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	Iron	95-99	lipocalin 2	Rattus norvegicus	0-11
30871254-4	2019	Lipocalin-2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	Iron	95-99	lipocalin 2	Rattus norvegicus	13-17
30713077-6	2019	Fe uptake is dependent on CBL1/CBL9.	Iron	0-2	calcineurin B-like protein 1	Arabidopsis thaliana	26-30
30850661-1	2019	Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin.	Iron	47-51	transferrin receptor	Homo sapiens	30-34
30850661-1	2019	Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin.	Iron	90-94	transferrin receptor	Homo sapiens	30-34
30713087-0	2019	Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis.	Iron	84-88	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	66-70
30713087-3	2019	Here, we utilized ginger NP-derived lipid vectors (GDLVs) in a proof-of-concept investigation to test the hypothesis that inhibiting expression of divalent metal-ion transporter 1 (Dmt1) would attenuate iron loading in a mouse model of hereditary hemochromatosis (HH).	Iron	203-207	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	181-185
30713087-6	2019	Hence, intestinal Dmt1 is required for the excessive iron absorption that typifies HH.	Iron	53-57	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	18-22
30713087-8	2019	When FA-GDLVs carrying Dmt1 siRNA were administered to weanling Hepc-/- mice for 16 days, intestinal Dmt1 mRNA expression was attenuated and tissue iron accumulation was blunted.	Iron	148-152	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	23-27
30586625-8	2019	IRE-IRP interaction was affected due to conversion of IRP1 to cytosolic aconitase that was influenced by increased iron-sulfur scaffold protein iron-sulfur cluster assembly enzyme (ISCU) level.	Iron	144-148	Wnt family member 2	Homo sapiens	4-7
30586625-8	2019	IRE-IRP interaction was affected due to conversion of IRP1 to cytosolic aconitase that was influenced by increased iron-sulfur scaffold protein iron-sulfur cluster assembly enzyme (ISCU) level.	Iron	144-148	aconitase 1	Homo sapiens	54-58
30423260-3	2019	Herein, we show that iron uptake and the mRNA expression of iron importer divalent metal transporter 1 (DMT1) were significantly increased in the duodenum of streptozotocin-induced diabetic mice.	Iron	21-25	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	104-108
30218771-2	2019	In mammalian cells, iron regulatory protein 1 and 2 (IRP1 and IRP2) are the central regulators of cellular iron metabolism.	Iron	20-24	aconitase 1	Homo sapiens	53-57
30316781-6	2019	A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6.	Iron	93-97	solute carrier family 39 member 14	Homo sapiens	119-124
30873034-6	2019	Meanwhile, we found that iron overload induced by 100 muM FAC significantly inhibited mitochondrial fission protein FIS1 and fusion protein MFN2 expressions, inhibited DRP1 and Cytochrome C protein translocation from the cytoplasm to mitochondria.	Iron	25-29	collapsin response mediator protein 1	Homo sapiens	168-172
30813537-4	2019	DMT1-knockout suppressed the synthesis of ferritin and inhibited the response of iron regulatory protein 1 (IRP-1) and IRP-2 to these two iron sources.	Iron	81-85	aconitase 1	Homo sapiens	108-113
30813537-6	2019	Interestingly, the expression of zinc-regulated transporter (ZRT) and iron-regulated transporter (IRT)-like protein 14 (Zip14) was elevated significantly by knockout and iron treatment in wild-type cells (p &lt; 0.05).	Iron	70-74	solute carrier family 39 member 14	Homo sapiens	120-125
30813537-7	2019	These results indicated that iron from Fe-Gly was probably mainly transported into enterocytes via DMT1 like FeSO4; Zip14 may play a certain role in the intestinal iron transport.	Iron	29-33	solute carrier family 39 member 14	Homo sapiens	116-121
30813537-7	2019	These results indicated that iron from Fe-Gly was probably mainly transported into enterocytes via DMT1 like FeSO4; Zip14 may play a certain role in the intestinal iron transport.	Iron	164-168	solute carrier family 39 member 14	Homo sapiens	116-121
30609139-3	2019	The optimized LFNO-II NRs with Ni/Fe ratio of 8:2 achieve a low overpotential of 302 mV at 10 mA cm-2 and a small Tafel slope of 50 mV dec-1 , outperforming those of the commercial Ir/C.	Iron	34-36	deleted in esophageal cancer 1	Homo sapiens	135-140
31278166-0	2019	Human DNA polymerase delta requires an iron-sulfur cluster for high-fidelity DNA synthesis.	Iron	39-43	DNA polymerase delta 1, catalytic subunit	Homo sapiens	6-26
31132316-6	2019	Accordingly, upon treatment with 50 muM iron, these chondrocytes were found to preferentially differentiate toward hypertrophy with increased expression of collagen I and transferrin and downregulation of SRY (sex-determining region Y)-box containing gene 9 (Sox9).	Iron	40-44	SRY (sex determining region Y)-box 9	Mus musculus	259-263
30630985-1	2019	Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis.	Iron	65-69	nuclear receptor coactivator 4	Mus musculus	0-5
30630985-1	2019	Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis.	Iron	113-117	nuclear receptor coactivator 4	Mus musculus	0-5
30630985-2	2019	Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.	Iron	59-63	nuclear receptor coactivator 4	Mus musculus	41-46
30630985-3	2019	However, the specific contribution and temporal importance of Ncoa4-mediated ferritinophagy in regulating systemic iron homeostasis and erythropoiesis is unclear.	Iron	115-119	nuclear receptor coactivator 4	Mus musculus	62-67
30630985-4	2019	Here, we show that Ncoa4 has a critical role in basal systemic iron homeostasis and both cell autonomous and non-autonomous roles in murine erythropoiesis.	Iron	63-67	nuclear receptor coactivator 4	Mus musculus	19-24
30630985-5	2019	Using an inducible murine model of Ncoa4 knockout, acute systemic disruption of Ncoa4 impaired systemic iron homeostasis leading to tissue ferritin and iron accumulation, a decrease in serum iron, and anemia.	Iron	104-108	nuclear receptor coactivator 4	Mus musculus	35-40
30630985-5	2019	Using an inducible murine model of Ncoa4 knockout, acute systemic disruption of Ncoa4 impaired systemic iron homeostasis leading to tissue ferritin and iron accumulation, a decrease in serum iron, and anemia.	Iron	104-108	nuclear receptor coactivator 4	Mus musculus	80-85
30630985-5	2019	Using an inducible murine model of Ncoa4 knockout, acute systemic disruption of Ncoa4 impaired systemic iron homeostasis leading to tissue ferritin and iron accumulation, a decrease in serum iron, and anemia.	Iron	152-156	nuclear receptor coactivator 4	Mus musculus	80-85
30630985-8	2019	These studies demonstrate the importance of Ncoa4-mediated ferritinophagy as a regulator of systemic iron homeostasis and define the relative cell autonomous and non-autonomous contributions of Ncoa4 in supporting erythropoiesis in vivo.	Iron	101-105	nuclear receptor coactivator 4	Mus musculus	44-49
31263155-2	2019	Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in multiple brain regions and that this was paralleled by increased oxidative damage and deficits in cognition and memory.	Iron	108-112	hephaestin	Mus musculus	33-43
31263155-2	2019	Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in multiple brain regions and that this was paralleled by increased oxidative damage and deficits in cognition and memory.	Iron	108-112	hephaestin	Mus musculus	45-49
31263155-6	2019	The expression of Heph, Cp, and other iron-related genes was examined in astrocytes and oligodendrocytes both with and without iron treatment.	Iron	127-131	hephaestin	Mus musculus	18-22
31263155-8	2019	Our findings collectively demonstrate that HEPH and CP are important for the prevention of glial iron accumulation and thus may be protective against oxidative damage.	Iron	97-101	hephaestin	Mus musculus	43-47
30980982-4	2019	METHODS: A FE model of the L1-5 segments was developed and validated.	Iron	11-13	immunoglobulin kappa variable 1D-16	Homo sapiens	27-31
31088072-0	2019	Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2.	Iron	25-29	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	71-77
31040179-6	2019	Mitochondria then exported (Fe-S)int via the Atm1 transporter in the inner membrane, and we detected (Fe-S)int in active form.	Iron	28-32	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	45-49
30866174-4	2019	In electrochemical testing, the trimetallic oxide CoFeNi-O-1 (derived from the MOG with a Co/Fe/Ni molar ratio of 5:1:4) exhibits remarkable catalytic activity with a low overpotential of 244 mV at a current density of 10 mA cm-2 and a small Tafel slope of 55.4 mV dec-1 in alkaline electrolyte, outperforming most recently reported electrocatalysts.	Iron	52-54	myelin oligodendrocyte glycoprotein	Homo sapiens	79-82
30866174-4	2019	In electrochemical testing, the trimetallic oxide CoFeNi-O-1 (derived from the MOG with a Co/Fe/Ni molar ratio of 5:1:4) exhibits remarkable catalytic activity with a low overpotential of 244 mV at a current density of 10 mA cm-2 and a small Tafel slope of 55.4 mV dec-1 in alkaline electrolyte, outperforming most recently reported electrocatalysts.	Iron	52-54	deleted in esophageal cancer 1	Homo sapiens	265-270
30975898-0	2019	Mechanism of frataxin "bypass" in human iron-sulfur cluster biosynthesis with implications for Friedreich"s ataxia.	Iron	40-44	frataxin	Homo sapiens	13-21
30968250-5	2019	The literature review revealed that most published interaction studies have been candidate gene studies, causing observed interactions to cluster in a few genes related to detoxification (GSTM1 and GSTT1), inflammation (IL-6), iron processing (HFE), and microRNA processing (GEMIN4 and DGCR8).	Iron	227-231	homeostatic iron regulator	Homo sapiens	244-247
30968250-5	2019	The literature review revealed that most published interaction studies have been candidate gene studies, causing observed interactions to cluster in a few genes related to detoxification (GSTM1 and GSTT1), inflammation (IL-6), iron processing (HFE), and microRNA processing (GEMIN4 and DGCR8).	Iron	227-231	gem nuclear organelle associated protein 4	Homo sapiens	275-281
30999072-4	2019	GSNOR overexpression positively regulated the Fe distribution from root to shoot, which might result from the transcriptional regulation of genes involved in Fe metabolism.	Iron	46-48	alcohol dehydrogenase class III	Solanum lycopersicum	0-5
30999072-4	2019	GSNOR overexpression positively regulated the Fe distribution from root to shoot, which might result from the transcriptional regulation of genes involved in Fe metabolism.	Iron	158-160	alcohol dehydrogenase class III	Solanum lycopersicum	0-5
30999072-5	2019	Additionally, the overexpression of GSNOR maintained redox homeostasis and protected chloroplasts from Fe-deficiency-related damage, resulting in a greater photosynthetic capacity.	Iron	103-105	alcohol dehydrogenase class III	Solanum lycopersicum	36-41
30999072-7	2019	Moreover, GSNOR overexpression, probably at the level of genes and proteins, along with protein S-nitrosylation, promoted Fe uptake and regulated the shoot/root Fe ratio under Fe-deficiency conditions.	Iron	122-124	alcohol dehydrogenase class III	Solanum lycopersicum	10-15
30999072-7	2019	Moreover, GSNOR overexpression, probably at the level of genes and proteins, along with protein S-nitrosylation, promoted Fe uptake and regulated the shoot/root Fe ratio under Fe-deficiency conditions.	Iron	161-163	alcohol dehydrogenase class III	Solanum lycopersicum	10-15
31038957-1	2019	Phenylalanine hydroxylase (PAH) is an iron enzyme catalyzing the oxidation of l-Phe to l-Tyr during phenylalanine catabolism.	Iron	38-42	phenylalanine hydroxylase	Homo sapiens	0-25
31038957-1	2019	Phenylalanine hydroxylase (PAH) is an iron enzyme catalyzing the oxidation of l-Phe to l-Tyr during phenylalanine catabolism.	Iron	38-42	phenylalanine hydroxylase	Homo sapiens	27-30
30888356-4	2019	Tmprss6-/- mice showed frank iron deficiency and reduced iron levels in most tissues, consistent with FPN playing an important role in the distribution of this metal, but manganese levels were largely unaffected.	Iron	29-33	transmembrane serine protease 6	Mus musculus	0-7
31101807-0	2019	Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.	Iron	38-42	frataxin	Homo sapiens	23-31
31101807-1	2019	The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP.	Iron	47-51	NFS1 cysteine desulfurase	Homo sapiens	173-177
31101807-1	2019	The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP.	Iron	47-51	frataxin	Homo sapiens	199-207
31101807-1	2019	The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP.	Iron	47-51	frataxin	Homo sapiens	209-212
30844566-6	2019	It is found that Fe/N-HCS improve the hydrogen evolution reaction activity after electrodeposition trace quantity of Pt, which shows 170 mV of overpotential to deliver 100 mA cm-2.	Iron	17-19	holocarboxylase synthetase	Homo sapiens	22-25
30888858-9	2019	DOX reduced iron transport capacity through reduced transferrin receptor levels in heart and skeletal muscle.	Iron	12-16	transferrin receptor	Mus musculus	52-72
32121273-2	2020	The hallmark of this regulated cell death is the presence of iron-driven lipid peroxidation; the activation of key genes related to this process such as glutathione peroxidase-4 (gpx4), acyl-CoA synthetase long-chain family member-4 (acsl4), carbonyl reductase [NADPH] 3 (cbr3), and prostaglandin peroxidase synthase-2 (ptgs2); and morphological changes including shrunken and electron-dense mitochondria.	Iron	61-65	carbonyl reductase 3	Homo sapiens	272-276
30827762-0	2019	The p.H63D allele of the HFE gene protects against low iron stores in Sri Lanka.	Iron	55-59	homeostatic iron regulator	Homo sapiens	25-28
30409066-0	2019	The relation of SF3B1 mutation and intracellular iron in myelodysplastic syndrome with less than 5% bone marrow blasts.	Iron	49-53	splicing factor 3b subunit 1	Homo sapiens	16-21
30409066-4	2019	We found that there was a significant difference between SF3B1-mutant and SF3B1-wild-type MDS patients in intracellular iron III, intracellular iron IV and ring sideroblasts.	Iron	120-124	splicing factor 3b subunit 1	Homo sapiens	57-62
32079304-6	2020	At molecular level, cells cultured in iron-enriched conditions show increased ARG1 and PU.1, and decreased IRF8 expression.	Iron	38-42	arginase 1	Homo sapiens	78-82
30833328-7	2019	In conclusion, both the MCRC and TfR1 mediate hTf uptake across apical brush border membranes of PTECs and reciprocally respond to decreased cellular iron.	Iron	150-154	transferrin receptor	Rattus norvegicus	33-37
31585279-2	2020	The UV-irradiated Fe-incorporated ZSM-5 (UV-FZ5) showed structural and chemical changes arising due to UV-cleaving of framework bonds resulting in a decreased crystallinity and change in the local environment of Fe species.	Iron	18-20	frizzled class receptor 5	Homo sapiens	44-47
30817054-3	2019	F279S an X-linked mental retardation mutation in PHF8 is involved in correlated motions with the iron ligands and second sphere residues.	Iron	97-101	PHD finger protein 8	Homo sapiens	49-53
31585279-2	2020	The UV-irradiated Fe-incorporated ZSM-5 (UV-FZ5) showed structural and chemical changes arising due to UV-cleaving of framework bonds resulting in a decreased crystallinity and change in the local environment of Fe species.	Iron	212-214	frizzled class receptor 5	Homo sapiens	44-47
32075199-4	2020	The iron(II) complex (C1) is in the low spin [LS] state below room temperature and shows an increase in the magnetic moment only above 300 K. In contrast, the cobalt(II) complex (C2) shows a gradual spin crossover (SCO) with T1/2 = 175 K.	Iron	4-12	interleukin 1 receptor like 1	Homo sapiens	225-237
30958854-0	2019	Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.	Iron	71-75	SMAD family member 7	Mus musculus	45-49
30958854-0	2019	Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.	Iron	91-95	SMAD family member 7	Mus musculus	45-49
30958854-4	2019	Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA.	Iron	18-22	SMAD family member 7	Mus musculus	54-58
30958854-4	2019	Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA.	Iron	18-22	SMAD family member 7	Mus musculus	207-211
30958854-4	2019	Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA.	Iron	179-183	SMAD family member 7	Mus musculus	207-211
32117974-4	2020	Apart from its role for iron uptake, TfR is a coreceptor for hepatitis C virus (HCV) infection.	Iron	24-28	transferrin receptor	Homo sapiens	37-40
30806852-0	2019	Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells.	Iron	0-4	solute carrier family 39 member 8	Homo sapiens	15-19
30806852-5	2019	Ferrous iron importers ZIP8 and ZIP14 were localized in the ciPTEC plasma membrane.	Iron	8-12	solute carrier family 39 member 8	Homo sapiens	23-27
30806852-5	2019	Ferrous iron importers ZIP8 and ZIP14 were localized in the ciPTEC plasma membrane.	Iron	8-12	solute carrier family 39 member 14	Homo sapiens	32-37
30806852-9	2019	Furthermore, ZIP14 silencing decreased 55Fe uptake after 55Fe-Transferrin exposure (p &lt; 0.05), suggesting ZIP14 could be involved in early endosomal transport of TBI-derived iron into the cytosol.	Iron	177-181	solute carrier family 39 member 14	Homo sapiens	13-18
30806852-9	2019	Furthermore, ZIP14 silencing decreased 55Fe uptake after 55Fe-Transferrin exposure (p &lt; 0.05), suggesting ZIP14 could be involved in early endosomal transport of TBI-derived iron into the cytosol.	Iron	177-181	solute carrier family 39 member 14	Homo sapiens	109-114
30806852-10	2019	Our data suggest that human proximal tubular epithelial cells take up TBI and NTBI, where ZIP8 and ZIP14 are both involved in NTBI uptake, but ZIP14, not ZIP8, mediates TBI-derived iron uptake.	Iron	181-185	solute carrier family 39 member 14	Homo sapiens	143-148
32117974-13	2020	The significant lower number of TfR molecules on the cell surface is reflected by reduced transferrin binding/internalization and strong reduction of intracellular iron level.	Iron	164-168	transferrin receptor	Homo sapiens	32-35
30806852-11	2019	This knowledge provides more insights in the mechanisms of renal iron handling and suggests that ZIP8 and ZIP14 could be potential targets for limiting renal iron reabsorption and enhancing urinary iron excretion in systemic iron overload disorders.	Iron	65-69	solute carrier family 39 member 8	Homo sapiens	97-101
30806852-11	2019	This knowledge provides more insights in the mechanisms of renal iron handling and suggests that ZIP8 and ZIP14 could be potential targets for limiting renal iron reabsorption and enhancing urinary iron excretion in systemic iron overload disorders.	Iron	65-69	solute carrier family 39 member 14	Homo sapiens	106-111
30806852-11	2019	This knowledge provides more insights in the mechanisms of renal iron handling and suggests that ZIP8 and ZIP14 could be potential targets for limiting renal iron reabsorption and enhancing urinary iron excretion in systemic iron overload disorders.	Iron	158-162	solute carrier family 39 member 8	Homo sapiens	97-101
31733495-4	2020	GS1 showed 68%, 60%, and 99% higher maximum adsorption constant (qmax) for divalent metal ions: iron, copper, and manganese, respectively as compared to raw sand (RS).	Iron	96-100	pseudouridine 5'-phosphatase	Homo sapiens	0-3
30806852-11	2019	This knowledge provides more insights in the mechanisms of renal iron handling and suggests that ZIP8 and ZIP14 could be potential targets for limiting renal iron reabsorption and enhancing urinary iron excretion in systemic iron overload disorders.	Iron	158-162	solute carrier family 39 member 14	Homo sapiens	106-111
31896574-0	2020	The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.	Iron	18-22	Mmt1p	Saccharomyces cerevisiae S288C	38-42
30769268-22	2019	Comparison between three-dimensional structures (3D) of COX1 protein model in E. granulosus s.s. and E. canadensis species demonstrated an additional helix with two conserved iron binding sites in the COX1 protein of E. granulosus s.s. species.	Iron	175-179	cytochrome c oxidase subunit I	Echinococcus granulosus	56-60
31896574-0	2020	The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.	Iron	18-22	Mmt2p	Saccharomyces cerevisiae S288C	47-51
31896574-2	2020	Mmt1 and Mmt2 are nuclear encoded mitochondrial proteins that export iron from the mitochondria into the cytosol.	Iron	69-73	Mmt1p	Saccharomyces cerevisiae S288C	0-4
31896574-2	2020	Mmt1 and Mmt2 are nuclear encoded mitochondrial proteins that export iron from the mitochondria into the cytosol.	Iron	69-73	Mmt2p	Saccharomyces cerevisiae S288C	9-13
31896574-3	2020	Here, we report that MMT1 and MMT2 expression is transcriptionally regulated by two pathways: the low-iron sensing transcription factor Aft1 and the oxidant-sensing transcription factor Yap1.	Iron	102-106	Mmt1p	Saccharomyces cerevisiae S288C	21-25
30756474-0	2019	Role of mitochondrial calcium uniporter-mediated Ca2+ and iron accumulation in traumatic brain injury.	Iron	58-62	mitochondrial calcium uniporter	Mus musculus	8-39
30756474-1	2019	Previous studies have suggested that the cellular Ca2+ and iron homeostasis, which can be regulated by mitochondrial calcium uniporter (MCU), is associated with oxidative stress, apoptosis and many neurological diseases.	Iron	59-63	mitochondrial calcium uniporter	Mus musculus	103-134
31896574-3	2020	Here, we report that MMT1 and MMT2 expression is transcriptionally regulated by two pathways: the low-iron sensing transcription factor Aft1 and the oxidant-sensing transcription factor Yap1.	Iron	102-106	Mmt2p	Saccharomyces cerevisiae S288C	30-34
30756474-1	2019	Previous studies have suggested that the cellular Ca2+ and iron homeostasis, which can be regulated by mitochondrial calcium uniporter (MCU), is associated with oxidative stress, apoptosis and many neurological diseases.	Iron	59-63	mitochondrial calcium uniporter	Mus musculus	136-139
30756474-2	2019	However, little is known about the role of MCU-mediated Ca2+ and iron accumulation in traumatic brain injury (TBI).	Iron	65-69	mitochondrial calcium uniporter	Mus musculus	43-46
30756474-7	2019	Blockage of MCU by RR prevented Ca2+ and iron accumulation, abated the level of oxidative stress, improved the energy supply, stabilized mitochondria, reduced DNA damage and decreased apoptosis both in vivo and in vitro.	Iron	41-45	mitochondrial calcium uniporter	Mus musculus	12-15
30756474-10	2019	Taken together, our data demonstrated for the first time that blockage of MCU-mediated Ca2+ and iron accumulation was essential for TBI.	Iron	96-100	mitochondrial calcium uniporter	Mus musculus	74-77
30777083-9	2019	NOX2 and NOX4 inhibition significantly reduced ROS production among microglia exposed to iron and LPS and reduced neuronal damage and death in response to microglial co-culture.	Iron	89-93	NADPH oxidase 4	Homo sapiens	9-13
30777083-11	2019	Further, this study highlights both NOX2 and NOX4 as potential therapeutic targets in the treatment of iron-induced microglia-related inflammation and neurotoxicity.	Iron	103-107	NADPH oxidase 4	Homo sapiens	45-49
31896574-4	2020	We determined that MMT1 and MMT2 expression is increased under low-iron conditions and decreased when mitochondrial iron import is increased through overexpression of the high-affinity mitochondrial iron importer Mrs3.	Iron	67-71	Mmt1p	Saccharomyces cerevisiae S288C	19-23
30714148-4	2019	These include (i) kinase-mediated necroptosis, which depends on receptor interacting protein kinase 3 (RIPK3)-mediated phosphorylation of the pseudokinase mixed lineage kinase domain like (MLKL); (ii) gasdermin-mediated necrosis downstream of inflammasomes, also referred to as pyroptosis; and (iii) an iron-catalysed mechanism of highly specific lipid peroxidation named ferroptosis.	Iron	303-307	mixed lineage kinase domain like pseudokinase	Homo sapiens	189-193
31896574-4	2020	We determined that MMT1 and MMT2 expression is increased under low-iron conditions and decreased when mitochondrial iron import is increased through overexpression of the high-affinity mitochondrial iron importer Mrs3.	Iron	67-71	Mmt2p	Saccharomyces cerevisiae S288C	28-32
31896574-4	2020	We determined that MMT1 and MMT2 expression is increased under low-iron conditions and decreased when mitochondrial iron import is increased through overexpression of the high-affinity mitochondrial iron importer Mrs3.	Iron	116-120	Mmt1p	Saccharomyces cerevisiae S288C	19-23
30657865-2	2019	In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive iron absorption, fatigue, diabetes, arthritis, and liver disease, especially in men.	Iron	159-163	homeostatic iron regulator	Homo sapiens	43-46
31896574-4	2020	We determined that MMT1 and MMT2 expression is increased under low-iron conditions and decreased when mitochondrial iron import is increased through overexpression of the high-affinity mitochondrial iron importer Mrs3.	Iron	116-120	Mmt2p	Saccharomyces cerevisiae S288C	28-32
30925694-1	2019	A MIL series metal-organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET.	Iron	52-54	T-box transcription factor 1	Homo sapiens	135-138
31896574-4	2020	We determined that MMT1 and MMT2 expression is increased under low-iron conditions and decreased when mitochondrial iron import is increased through overexpression of the high-affinity mitochondrial iron importer Mrs3.	Iron	116-120	Mmt1p	Saccharomyces cerevisiae S288C	19-23
30925694-1	2019	A MIL series metal-organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET.	Iron	52-54	delta/notch like EGF repeat containing	Homo sapiens	160-163
31896574-4	2020	We determined that MMT1 and MMT2 expression is increased under low-iron conditions and decreased when mitochondrial iron import is increased through overexpression of the high-affinity mitochondrial iron importer Mrs3.	Iron	116-120	Mmt2p	Saccharomyces cerevisiae S288C	28-32
31938799-2	2020	An in vitro CYP17A1 binding pattern assay and protein-ligand docking model support that 2, like abiraterone, binds in the active site heme iron pocket of CYP17A1.	Iron	139-143	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	12-19
30659096-0	2019	SMAD family member 3 (SMAD3) and SMAD4 repress HIF2alpha-dependent iron-regulatory genes.	Iron	67-71	SMAD family member 4	Homo sapiens	0-4
30659096-0	2019	SMAD family member 3 (SMAD3) and SMAD4 repress HIF2alpha-dependent iron-regulatory genes.	Iron	67-71	SMAD family member 3	Homo sapiens	22-27
30659096-0	2019	SMAD family member 3 (SMAD3) and SMAD4 repress HIF2alpha-dependent iron-regulatory genes.	Iron	67-71	SMAD family member 4	Homo sapiens	33-38
30742009-5	2019	The nuclear/mitotic spindle associated protein Ccdc117 interacts with the MIP18/MMS19 cytoplasmic iron-sulfur (FeS) cluster assembly (CIA) complex, which transfers critical FeS clusters to several key enzymes with functions in DNA repair and replication.	Iron	111-114	MMS19 cytosolic iron-sulfur assembly component	Mus musculus	80-85
30742009-5	2019	The nuclear/mitotic spindle associated protein Ccdc117 interacts with the MIP18/MMS19 cytoplasmic iron-sulfur (FeS) cluster assembly (CIA) complex, which transfers critical FeS clusters to several key enzymes with functions in DNA repair and replication.	Iron	173-176	MMS19 cytosolic iron-sulfur assembly component	Mus musculus	80-85
30559294-8	2019	Further in vivo rescue studies indicated that the entire extracellular and transmembrane domains of MT2 are required to correct the low-hemoglobin, low-serum iron, and high-hepcidin status in MT2 -/- mice.	Iron	158-162	transmembrane serine protease 6	Mus musculus	100-103
30559294-10	2019	In conjunction with our previous studies implicating the cytoplasmic domain as an intracellular iron sensor, these observations reveal the importance of each MT2 domain for MT2-mediated substrate cleavage and for its biological function.	Iron	96-100	transmembrane serine protease 6	Mus musculus	158-161
31938799-2	2020	An in vitro CYP17A1 binding pattern assay and protein-ligand docking model support that 2, like abiraterone, binds in the active site heme iron pocket of CYP17A1.	Iron	139-143	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	154-161
30559294-10	2019	In conjunction with our previous studies implicating the cytoplasmic domain as an intracellular iron sensor, these observations reveal the importance of each MT2 domain for MT2-mediated substrate cleavage and for its biological function.	Iron	96-100	transmembrane serine protease 6	Mus musculus	173-176
31733261-1	2020	The zinc/iron permease (ZIP/SLC39A) family plays an important role in metal ion transport and is essential for diverse physiological processes.	Iron	9-13	unzipped	Drosophila melanogaster	24-27
30128746-8	2019	Interestingly, the mammalian Cth2 ortholog known as tristetraprolin (aka TTP/TIS11/ZFP36), which is also implicated in controlling iron metabolism, promotes the decay and prevents the translation of its regulated transcripts.	Iron	131-135	ZFP36 ring finger protein	Homo sapiens	52-67
30128746-8	2019	Interestingly, the mammalian Cth2 ortholog known as tristetraprolin (aka TTP/TIS11/ZFP36), which is also implicated in controlling iron metabolism, promotes the decay and prevents the translation of its regulated transcripts.	Iron	131-135	ZFP36 ring finger protein	Homo sapiens	73-76
30128746-8	2019	Interestingly, the mammalian Cth2 ortholog known as tristetraprolin (aka TTP/TIS11/ZFP36), which is also implicated in controlling iron metabolism, promotes the decay and prevents the translation of its regulated transcripts.	Iron	131-135	ZFP36 ring finger protein	Homo sapiens	77-82
30128746-8	2019	Interestingly, the mammalian Cth2 ortholog known as tristetraprolin (aka TTP/TIS11/ZFP36), which is also implicated in controlling iron metabolism, promotes the decay and prevents the translation of its regulated transcripts.	Iron	131-135	ZFP36 ring finger protein	Homo sapiens	83-88
30557609-5	2019	Mechanistically, DHA induced autophagy by regulating the activity of AMPK/mTOR/p70S6k signaling pathway, which accelerated the degradation of ferritin, increased the labile iron pool, promoted the accumulation of cellular ROS and eventually led to ferroptotic cell death.	Iron	173-177	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	69-73
31733261-2	2020	Members of the ZIP family function primarily in the influx of transition metal ions zinc and iron, into cytoplasm from extracellular space or intracellular organelles.	Iron	93-97	unzipped	Drosophila melanogaster	15-18
31733261-4	2020	Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway.	Iron	103-107	unzipped	Drosophila melanogaster	53-56
31733261-4	2020	Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway.	Iron	149-153	unzipped	Drosophila melanogaster	53-56
31837835-2	2020	Previous reports have revealed that a FA2H mutation leads to spastic paraplegia, leukodystrophy, and neurodegeneration with brain iron accumulation, collectively referred to as fatty acid hydroxylase-associated neurodegeneration (FAHN).	Iron	124-134	fatty acid 2-hydroxylase	Homo sapiens	38-42
30636112-2	2019	They have a pivotal role in iron-sulfur cluster biogenesis as regulators of the rates of cluster formation, as it is testified by the fact that frataxin absence is incompatible with life and reduced levels of the protein lead to the recessive neurodegenerative disease Friedreich"s ataxia.	Iron	28-32	frataxin	Homo sapiens	144-152
30636112-7	2019	We also characterized the iron-binding mode of Ct frataxin and demonstrated that it binds it through a semiconserved negatively charged ridge on the first helix and beta-strand.	Iron	26-30	frataxin	Homo sapiens	50-58
30636112-8	2019	Moreover, this frataxin is also able to bind the bacterial ortholog of the desulfurase, which is central in iron-sulfur cluster synthesis, and act as its inhibitor.	Iron	108-112	frataxin	Homo sapiens	15-23
31608986-6	2020	Under Pi deficiency, hdc1 accumulated higher levels of Fe3+ in the root tips and had higher expression of genes involved in RSA remodeling such as ALUMINUM-ACTIVATED MALATE TRANSPORTER1 (ALMT1), and LOW PHOSPHATE ROOT1 (LPR1), and LPR2 than wild-type plants.	Iron	55-59	zinc finger CCCH domain protein	Arabidopsis thaliana	21-25
29989313-0	2019	The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis.	Iron	59-63	circadian clock associated 1	Arabidopsis thaliana	37-41
29989313-3	2019	Here, we show that, in Arabidopsis thaliana, loss of the central clock genes, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), results in both reduced Fe uptake and photosynthetic efficiency, whereas CCA1 overexpression confers the opposite effects.	Iron	174-176	circadian clock associated 1	Arabidopsis thaliana	78-106
29989313-6	2019	Thus, this study established that, in plants, CCA1 and LHY function as master regulators that maintain cyclic Fe homeostasis.	Iron	110-112	circadian clock associated 1	Arabidopsis thaliana	46-50
31877117-3	2020	Friedreich ataxia is caused by intronic GAA trinucleotide repeat expansions in the frataxin-encoding FXN gene that reduce frataxin expression, impair iron-sulfur cluster biogenesis, cause oxidative stress, and result in mitochondrial dysfunction and apoptosis.	Iron	150-154	frataxin	Homo sapiens	83-91
30468944-7	2019	In particular, recent studies on the interactions of amylin with copper, zinc, iron, nickel, gold, ruthenium, and vanadium are discussed.	Iron	79-83	islet amyloid polypeptide	Homo sapiens	53-59
31877117-3	2020	Friedreich ataxia is caused by intronic GAA trinucleotide repeat expansions in the frataxin-encoding FXN gene that reduce frataxin expression, impair iron-sulfur cluster biogenesis, cause oxidative stress, and result in mitochondrial dysfunction and apoptosis.	Iron	150-154	frataxin	Homo sapiens	101-104
30420554-6	2019	RESULTS: Blast exposure led to a significant fall in iron-bound transferrin in both groups of animals (p&lt;0.001), which remained depressed during the study.	Iron	53-57	serotransferrin	Oryctolagus cuniculus	64-75
31843759-5	2020	We used this method to study the effect of iron depletion on transferrin receptor (TfR) recycling using the chelator desferrioxamine.	Iron	43-47	transferrin receptor	Homo sapiens	61-81
30173950-4	2019	Hemochromatoses, mostly but not exclusively related to the HFE gene, correspond to systemic iron overload of genetic origin in which iron excess is the consequence of hepcidin deficiency, hepcidin being the hormone regulating negatively plasma iron.	Iron	92-96	homeostatic iron regulator	Homo sapiens	59-62
30173950-4	2019	Hemochromatoses, mostly but not exclusively related to the HFE gene, correspond to systemic iron overload of genetic origin in which iron excess is the consequence of hepcidin deficiency, hepcidin being the hormone regulating negatively plasma iron.	Iron	133-137	homeostatic iron regulator	Homo sapiens	59-62
30173950-4	2019	Hemochromatoses, mostly but not exclusively related to the HFE gene, correspond to systemic iron overload of genetic origin in which iron excess is the consequence of hepcidin deficiency, hepcidin being the hormone regulating negatively plasma iron.	Iron	133-137	homeostatic iron regulator	Homo sapiens	59-62
31843759-5	2020	We used this method to study the effect of iron depletion on transferrin receptor (TfR) recycling using the chelator desferrioxamine.	Iron	43-47	transferrin receptor	Homo sapiens	83-86
31850467-5	2020	The optimized Co2.36Fe0.19Ni0.45-btca possesses the lowest overpotential of 292 mV at 10 mA cm-2 and a small Tafel slope of 72.6 mV dec-1.	Iron	20-22	deleted in esophageal cancer 1	Homo sapiens	132-137
30538134-0	2019	Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.	Iron	41-45	transferrin receptor	Mus musculus	0-22
32055716-4	2020	We further verified the authenticity of the ferric reductase activity of 101F6 using nitroso-PSAP as a Fe2+-specific colorimetric chelator.	Iron	103-107	cytochrome b561 family member D2	Homo sapiens	73-78
30538134-0	2019	Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.	Iron	111-115	transferrin receptor	Mus musculus	0-22
30538134-1	2019	Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types.	Iron	79-83	transferrin receptor	Mus musculus	0-22
30538134-1	2019	Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types.	Iron	79-83	transferrin receptor	Mus musculus	24-28
30538134-11	2019	We conclude that Tfr1 is redundant for basal hepatocellular iron supply but essential for fine-tuning hepcidin responses according to the iron load of hepatocytes.	Iron	60-64	transferrin receptor	Mus musculus	17-21
30538134-11	2019	We conclude that Tfr1 is redundant for basal hepatocellular iron supply but essential for fine-tuning hepcidin responses according to the iron load of hepatocytes.	Iron	138-142	transferrin receptor	Mus musculus	17-21
30538134-12	2019	Our data are consistent with an inhibitory function of Tfr1 on iron signaling to hepcidin via its interaction with Hfe.	Iron	63-67	transferrin receptor	Mus musculus	55-59
30538134-13	2019	Moreover, they highlight hepatocellular Tfr1 as a link between cellular and systemic iron-regulatory pathways.	Iron	85-89	transferrin receptor	Mus musculus	40-44
31941883-3	2020	Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes functional iron deficiency in beta cells.	Iron	42-46	transferrin receptor	Homo sapiens	62-84
30678305-1	2019	Iron based shape memory alloys (Fe-SMA) have recently been used as active flexural strengthening material for reinforced concrete (RC) beams.	Iron	0-4	survival of motor neuron 1, telomeric	Homo sapiens	35-38
31941883-3	2020	Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes functional iron deficiency in beta cells.	Iron	42-46	transferrin receptor	Homo sapiens	86-90
31456203-6	2019	After binding to transferrin receptor 1 (TfR1), the complex is endocytosed into the cell, where iron enters the cytoplasm via DMT1 on the endosomal membrane.	Iron	96-100	transferrin receptor	Homo sapiens	17-39
31696991-6	2020	Two iron complexes [(mtL42)FeCl](PF6) and [(mtL42)Fe(OTf)2]) were obtained and their reactivity studied towards aromatic substrates in the presence of H2O2.	Iron	4-8	sperm associated antigen 17	Homo sapiens	33-36
31456203-6	2019	After binding to transferrin receptor 1 (TfR1), the complex is endocytosed into the cell, where iron enters the cytoplasm via DMT1 on the endosomal membrane.	Iron	96-100	transferrin receptor	Homo sapiens	41-45
31456203-10	2019	Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs.	Iron	18-22	transferrin receptor	Homo sapiens	84-88
31456203-10	2019	Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs.	Iron	128-132	transferrin receptor	Homo sapiens	84-88
31456203-11	2019	Both the release of hepcidin and the IRP-IRE interaction are coordinated with the fluctuation of the cellular iron level.	Iron	110-114	Wnt family member 2	Homo sapiens	37-40
31114026-4	2020	Further, by associating with cellular free iron and thus stimulating the binding of iron-regulatory proteins (IRPs) with mRNA molecules containing iron-responsive element (IRE) sequences, DAT impinges on IRP/IRE-controlled iron homeostasis to further increase cellular free iron.	Iron	43-47	wingless-type MMTV integration site family, member 2	Mus musculus	110-113
30342111-1	2019	Frataxin plays a key role in cellular iron homeostasis of different organisms.	Iron	38-42	frataxin	Homo sapiens	0-8
30342111-5	2019	Here we analyze the possibility that frataxin acts as the iron donor to protoporphyrin IX for the synthesis of heme groups in plant mitochondria.	Iron	58-62	frataxin	Homo sapiens	37-45
30342111-6	2019	Our findings show that frataxin catalyzes the formation of heme in vitro when it is incubated with iron and protoporphyrin IX.	Iron	99-103	frataxin	Homo sapiens	23-31
30342111-8	2019	These results suggest that frataxin could be the iron donor in the final step of heme synthesis in plant mitochondria, and constitutes an important advance in the elucidation of the mechanisms of heme synthesis in plants.	Iron	49-53	frataxin	Homo sapiens	27-35
31114026-4	2020	Further, by associating with cellular free iron and thus stimulating the binding of iron-regulatory proteins (IRPs) with mRNA molecules containing iron-responsive element (IRE) sequences, DAT impinges on IRP/IRE-controlled iron homeostasis to further increase cellular free iron.	Iron	84-88	wingless-type MMTV integration site family, member 2	Mus musculus	110-113
31114026-4	2020	Further, by associating with cellular free iron and thus stimulating the binding of iron-regulatory proteins (IRPs) with mRNA molecules containing iron-responsive element (IRE) sequences, DAT impinges on IRP/IRE-controlled iron homeostasis to further increase cellular free iron.	Iron	84-88	wingless-type MMTV integration site family, member 2	Mus musculus	110-113
31114026-4	2020	Further, by associating with cellular free iron and thus stimulating the binding of iron-regulatory proteins (IRPs) with mRNA molecules containing iron-responsive element (IRE) sequences, DAT impinges on IRP/IRE-controlled iron homeostasis to further increase cellular free iron.	Iron	84-88	wingless-type MMTV integration site family, member 2	Mus musculus	110-113
30806315-9	2019	CONCLUSION: IKZF1 rs4132601 and rs10272724 could be considered significant risk contributors to childhood acute lymphoblastic leukaemia and may impact the iron profiles in these children.	Iron	155-159	IKAROS family zinc finger 1	Homo sapiens	12-17
30659096-6	2019	Further analysis revealed that SMAD4 signaling selectively represses iron-absorptive gene promoters but not the inflammatory or glycolytic HIF2alpha or HIF1alpha target genes.	Iron	69-73	SMAD family member 4	Homo sapiens	31-36
30659096-8	2019	During iron deficiency, SMAD3 and SMAD4 expression was significantly decreased via proteasomal degradation, allowing for derepression of iron target genes.	Iron	7-11	SMAD family member 3	Homo sapiens	24-29
31470311-3	2020	The Fe-based heterogeneous catalyst carried the higher potential to improve the biodegradability of ROC (i.e., 0.32 v. s. 0.27 for B/C, the ratio between BOD5 and COD) although its direct COD removal efficiency was inferior to the homogeneous one (i.e., 49% v. s. 59% after 25 min" reaction).	Iron	4-6	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	163-166
30659096-8	2019	During iron deficiency, SMAD3 and SMAD4 expression was significantly decreased via proteasomal degradation, allowing for derepression of iron target genes.	Iron	7-11	SMAD family member 4	Homo sapiens	34-39
30866815-11	2019	CONCLUSIONS: These results indicated that TpSnRK2.10 and TpSnRK2.11 are involved in the uptakes and the translocations of Cd and Fe, possibly by regulating the expression of AtNRAMP1 and AtHMA4, and other genes involved in the synthesis of phytochelatins or hemicellolosic polysaccharides.	Iron	129-131	heavy metal atpase 4	Arabidopsis thaliana	187-193
30814790-6	2019	In addition, serum cystatin-C and beta-2 microglobulin levels were positively correlated with blood urea, serum creatinine, serum ferritin, urinary albumin/creatinine ratio, duration of iron chelating agents and frequency of blood transfusion/year.	Iron	186-190	cystatin C	Homo sapiens	19-29
31470311-3	2020	The Fe-based heterogeneous catalyst carried the higher potential to improve the biodegradability of ROC (i.e., 0.32 v. s. 0.27 for B/C, the ratio between BOD5 and COD) although its direct COD removal efficiency was inferior to the homogeneous one (i.e., 49% v. s. 59% after 25 min" reaction).	Iron	4-6	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	188-191
31205627-2	2019	Because the roles of hepcidin antimicrobial peptide (HAMP) and hemocromatosis protein (HFE) in iron metabolism have been confirmed, this study investigated the effects of these gene"s polymorphisms on blood ferritin levels and iron overload in the heart and liver in patients with beta thalassemia major Materials and Methods: This cross-sectional study was conducted on 91 patients referring to the Hajar Hospital in Shahrekord, Iran in 2015.	Iron	95-99	homeostatic iron regulator	Homo sapiens	87-90
31746130-6	2020	Notably, VEGFR2 inhibition also decreased the appearance of lesion haemorrhage as denoted by the presence of free iron in adjacent tissues.	Iron	114-118	kinase insert domain protein receptor	Mus musculus	9-15
30652531-7	2019	Our results showed that FeD produced a significant reduction in MBP and PMP22 content at P29, which persisted at P60 after Fe-sufficient diet replenishment regardless of Mn exposure levels.	Iron	24-26	SYF2 pre-mRNA-splicing factor	Rattus norvegicus	89-92
30622135-5	2019	Here, we report that human calprotectin (CP; S100A8/S100A9 or MRP8/MRP14 heterooligomer) inhibits iron uptake and induces an iron starvation response in Pseudomonas aeruginosa cells by sequestering Fe(II) at its unusual His6 site.	Iron	98-102	S100 calcium binding protein A8	Homo sapiens	45-51
30622135-5	2019	Here, we report that human calprotectin (CP; S100A8/S100A9 or MRP8/MRP14 heterooligomer) inhibits iron uptake and induces an iron starvation response in Pseudomonas aeruginosa cells by sequestering Fe(II) at its unusual His6 site.	Iron	98-102	S100 calcium binding protein A8	Homo sapiens	62-66
30622135-5	2019	Here, we report that human calprotectin (CP; S100A8/S100A9 or MRP8/MRP14 heterooligomer) inhibits iron uptake and induces an iron starvation response in Pseudomonas aeruginosa cells by sequestering Fe(II) at its unusual His6 site.	Iron	125-129	S100 calcium binding protein A8	Homo sapiens	45-51
30622135-5	2019	Here, we report that human calprotectin (CP; S100A8/S100A9 or MRP8/MRP14 heterooligomer) inhibits iron uptake and induces an iron starvation response in Pseudomonas aeruginosa cells by sequestering Fe(II) at its unusual His6 site.	Iron	125-129	S100 calcium binding protein A8	Homo sapiens	62-66
30984307-0	2019	Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease.	Iron	78-82	homeostatic iron regulator	Homo sapiens	35-38
32042647-2	2020	Research in other species has shown elevated body iron levels as both a predictor and consequence of insulin resistance.	Iron	50-54	INS	Equus caballus	101-108
30659730-1	2019	The high-valence iron species (Fe(IV)=O) in the cytochrome P450 enzyme superfamily is generated via the activation of O2 , and serves as the active center of selective hydrocarbon oxidation reactions.	Iron	17-21	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	59-63
32042647-7	2020	Pearson correlation was used to test the relationship between insulin and iron indices.	Iron	74-78	INS	Equus caballus	62-69
32042647-8	2020	Additionally, we performed a secondary analysis of a previously reported controlled trial that was originally designed to test the correlation between iron status and the insulin response in horses.	Iron	151-155	INS	Equus caballus	171-178
31221059-1	2019	Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include regulation of gene transcription, regulation of pre-mRNA processing, splicing, mRNA stability, translational silencing and enhancement, the control of iron turnover, and many others.	Iron	309-313	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	81-88
31491633-2	2019	Although the AP activity (APA) is conventionally thought to be a main response to PO43- starvation, significant effects of macro metal elements (Al, Fe, and Ca) and S on the APA were found in this study.	Iron	149-151	glutamyl aminopeptidase	Homo sapiens	174-177
29958932-7	2019	In this review, we propose the following four major reasons for oxidative stress in CKD patients: 1) iron is sequestered in cells by proinflammatory cytokines and hepcidin; 2) the reduction in frataxin increases "free" iron in mitochondria; 3) the accumulation of 5-aminolevulinic acid, a heme precursor, has toxic effects on iron and mitochondrial metabolism; and 4) the elevated levels of the metabolic hormone, leptin, promote hepatic hepcidin production.	Iron	101-105	frataxin	Homo sapiens	193-201
29958932-7	2019	In this review, we propose the following four major reasons for oxidative stress in CKD patients: 1) iron is sequestered in cells by proinflammatory cytokines and hepcidin; 2) the reduction in frataxin increases "free" iron in mitochondria; 3) the accumulation of 5-aminolevulinic acid, a heme precursor, has toxic effects on iron and mitochondrial metabolism; and 4) the elevated levels of the metabolic hormone, leptin, promote hepatic hepcidin production.	Iron	219-223	frataxin	Homo sapiens	193-201
29958932-7	2019	In this review, we propose the following four major reasons for oxidative stress in CKD patients: 1) iron is sequestered in cells by proinflammatory cytokines and hepcidin; 2) the reduction in frataxin increases "free" iron in mitochondria; 3) the accumulation of 5-aminolevulinic acid, a heme precursor, has toxic effects on iron and mitochondrial metabolism; and 4) the elevated levels of the metabolic hormone, leptin, promote hepatic hepcidin production.	Iron	219-223	frataxin	Homo sapiens	193-201
29969719-2	2019	Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis.	Iron	9-13	transferrin receptor	Homo sapiens	38-49
31856248-1	2019	The homeostatic iron regulator protein HFE is involved in regulation of iron acquisition for cells.	Iron	16-20	homeostatic iron regulator	Homo sapiens	39-42
29969719-2	2019	Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis.	Iron	9-13	transferrin receptor	Homo sapiens	51-54
29969719-3	2019	TfR1 can mediate cellular uptake of both Tf and H-ferritin, an iron storage protein.	Iron	63-67	transferrin receptor	Homo sapiens	0-4
30553971-0	2019	Suppressive effects of iron chelation in clear cell renal cell carcinoma and their dependency on VHL inactivation.	Iron	23-27	von Hippel-Lindau tumor suppressor	Homo sapiens	97-100
31856248-1	2019	The homeostatic iron regulator protein HFE is involved in regulation of iron acquisition for cells.	Iron	72-76	homeostatic iron regulator	Homo sapiens	39-42
30553971-2	2019	The von Hippel Lindau (VHL)/hypoxia inducible factor-alpha (HIF-alpha) axis is uniquely dysregulated in ccRCC and is a major regulator and regulatory target of iron metabolism, yet the role of iron in ccRCC tumorigenesis and its potential interplay with VHL inactivation remains unclear.	Iron	160-164	von Hippel-Lindau tumor suppressor	Homo sapiens	4-21
30553971-2	2019	The von Hippel Lindau (VHL)/hypoxia inducible factor-alpha (HIF-alpha) axis is uniquely dysregulated in ccRCC and is a major regulator and regulatory target of iron metabolism, yet the role of iron in ccRCC tumorigenesis and its potential interplay with VHL inactivation remains unclear.	Iron	160-164	von Hippel-Lindau tumor suppressor	Homo sapiens	23-26
31704097-4	2019	BVR-deficiency induces the activity of Nrf2 transcription factor and increases heme oxygenase-1 (HO-1) level, which is accompanied by the reduction of cellular heme content, increase in a free iron fraction and oxidative stress.	Iron	193-197	biliverdin reductase A	Homo sapiens	0-3
30553971-12	2019	Restoration of wild-type VHL function in ccRCC cells was sufficient to prevent chelator-induced apoptosis and G1 cell cycle arrest, indicating that ccRCC susceptibility to iron deprivation is VHL inactivation-dependent.	Iron	172-176	von Hippel-Lindau tumor suppressor	Homo sapiens	25-28
30553971-12	2019	Restoration of wild-type VHL function in ccRCC cells was sufficient to prevent chelator-induced apoptosis and G1 cell cycle arrest, indicating that ccRCC susceptibility to iron deprivation is VHL inactivation-dependent.	Iron	172-176	von Hippel-Lindau tumor suppressor	Homo sapiens	192-195
30553971-14	2019	This iron dependency is introduced by VHL inactivation, revealing a novel interplay between VHL/HIF-alpha dysregulation and ccRCC iron metabolism.	Iron	5-9	von Hippel-Lindau tumor suppressor	Homo sapiens	38-41
30553971-14	2019	This iron dependency is introduced by VHL inactivation, revealing a novel interplay between VHL/HIF-alpha dysregulation and ccRCC iron metabolism.	Iron	5-9	von Hippel-Lindau tumor suppressor	Homo sapiens	92-95
30535838-5	2019	Mitochondrial ATP-binding cassette (ABC) transporters have a key role in regulating iron metabolism and maintenance of redox status in cells.	Iron	84-88	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	14-34
31704097-5	2019	Accordingly, the phenotype of BVR-deficient cells can be mimicked by hemin or iron overload, whereas depletion of HO-1 in BVR-deficient ECs abrogates the increase in intracellular free iron and oxidative stress, preventing the loss of endothelial markers.	Iron	78-82	biliverdin reductase A	Homo sapiens	30-33
30535838-5	2019	Mitochondrial ATP-binding cassette (ABC) transporters have a key role in regulating iron metabolism and maintenance of redox status in cells.	Iron	84-88	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	36-39
31704097-8	2019	Collectively, the non-enzymatic activity of BVR contributes to the maintenance of healthy endothelial phenotype through the prevention of HO-1-dependent iron-overload, oxidative stress and subsequent endothelial-to-mesenchymal transition (EndMT).	Iron	153-157	biliverdin reductase A	Homo sapiens	44-47
31676601-0	2019	Iron Metabolism in the Peripheral Nervous System: The Role of DMT1, Ferritin, and Transferrin Receptor in Schwann Cell Maturation and Myelination.	Iron	0-4	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	62-66
30470799-8	2019	IREs interact with iron response protein1 (IRP1), an iron-dependent translational repressor.	Iron	19-23	aconitase 1	Homo sapiens	43-47
30470799-8	2019	IREs interact with iron response protein1 (IRP1), an iron-dependent translational repressor.	Iron	53-57	aconitase 1	Homo sapiens	43-47
31676601-10	2019	These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs.	Iron	90-94	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	28-32
31676601-10	2019	These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs.	Iron	90-94	transferrin receptor	Mus musculus	43-47
30787468-2	2019	The following sentence has been inserted following the sentence ending "Aspergillus phytase" in the third paragraph of the article: "Overexpression of AtIRT1, AtNAS1 and bean FERRITIN in rice resulted in 3.8-fold higher iron and 1.8-fold higher zinc concentrations than in the wild-type control12."	Iron	220-224	nicotianamine synthase 1	Arabidopsis thaliana	159-165
31676601-10	2019	These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs.	Iron	90-94	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	238-266
31676601-10	2019	These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs.	Iron	90-94	transferrin receptor	Mus musculus	272-294
31473256-3	2019	Mitochondrial unacylated holo-ACP is a component of mammalian mitoribosomes, and acylated ACP species participate as interaction partners in several ACP-LYRM (leucine-tyrosine-arginine motif)-protein heterodimers that act either as assembly factors or subunits of the electron transport chain and Fe-S cluster assembly complexes.	Iron	297-301	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	30-33
30820268-0	2019	Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload.	Iron	106-110	homeostatic iron regulator	Homo sapiens	26-29
30820268-2	2019	HFE gene controls the iron uptake from gut, particularly in patients with hereditary hemochromatosis (HH).	Iron	22-26	homeostatic iron regulator	Homo sapiens	0-3
31473256-3	2019	Mitochondrial unacylated holo-ACP is a component of mammalian mitoribosomes, and acylated ACP species participate as interaction partners in several ACP-LYRM (leucine-tyrosine-arginine motif)-protein heterodimers that act either as assembly factors or subunits of the electron transport chain and Fe-S cluster assembly complexes.	Iron	297-301	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	90-93
31473256-3	2019	Mitochondrial unacylated holo-ACP is a component of mammalian mitoribosomes, and acylated ACP species participate as interaction partners in several ACP-LYRM (leucine-tyrosine-arginine motif)-protein heterodimers that act either as assembly factors or subunits of the electron transport chain and Fe-S cluster assembly complexes.	Iron	297-301	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	90-93
31016121-2	2019	Here, mesoporous metal-organic frameworks (MOFs) NH2-MIL-101(Fe) as a core generate a shell with mesoporous covalent organic frameworks (COFs) NUT-COF-1(NTU) by a covalent linking process, the composite NH2-MIL-101(Fe)@NTU keeping retentive crystallinity with hierarchical porosity well.	Iron	61-63	NUT midline carcinoma family member 1	Homo sapiens	143-146
31660701-6	2019	We can mechanistically link a defect in CoA metabolism to these secondary effects via the activation of mitochondrial acyl carrier protein, which is essential to oxidative phosphorylation, iron-sulfur cluster biogenesis, and mitochondrial fatty acid synthesis.	Iron	189-193	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	104-138
30833885-4	2019	The first experimental evidence connecting frataxin with iron homeostasis came from Saccharomyces cerevisiae; iron accumulates in the mitochondria of yeast with deletion of the frataxin ortholog gene.	Iron	57-61	frataxin	Homo sapiens	43-51
30833885-4	2019	The first experimental evidence connecting frataxin with iron homeostasis came from Saccharomyces cerevisiae; iron accumulates in the mitochondria of yeast with deletion of the frataxin ortholog gene.	Iron	110-114	frataxin	Homo sapiens	43-51
31548055-4	2019	The &lt;3 kDa fraction of the 16 h hydrolysate had an ACE inhibitory activity with a half-maximal inhibitory concentration (IC50) of 71.77 microg peptides per mL; DPPH and ABTS + radical scavenging activities of 6.27 microM and 6.21 mM Trolox equivalents per mg of peptides, respectively; and iron (II) chelation activity with an IC50 of 221.49 microg of peptides per mL.	Iron	293-297	angiotensin I converting enzyme	Bos taurus	54-57
30833885-4	2019	The first experimental evidence connecting frataxin with iron homeostasis came from Saccharomyces cerevisiae; iron accumulates in the mitochondria of yeast with deletion of the frataxin ortholog gene.	Iron	110-114	frataxin	Homo sapiens	177-185
30833885-9	2019	Mechanisms of mitochondrial iron overload are discussed considering the potential roles of frataxin in the major mitochondrial metabolic pathways that use iron.	Iron	28-32	frataxin	Homo sapiens	91-99
30833885-9	2019	Mechanisms of mitochondrial iron overload are discussed considering the potential roles of frataxin in the major mitochondrial metabolic pathways that use iron.	Iron	155-159	frataxin	Homo sapiens	91-99
30521948-0	2019	The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.	Iron	19-23	C-X-C motif chemokine ligand 10	Rattus norvegicus	114-120
30521948-0	2019	The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.	Iron	96-100	C-X-C motif chemokine ligand 10	Rattus norvegicus	114-120
31494282-7	2019	The consequent deficiency of frataxin protein leads to reduced iron-sulfur cluster biogenesis and mitochondrial ATP production, elevated mitochondrial iron, and oxidative stress.	Iron	63-67	frataxin	Homo sapiens	29-37
30521948-5	2019	Here, we examined whether iron accumulation regulated neuropathic pain via CXCL10.	Iron	26-30	C-X-C motif chemokine ligand 10	Rattus norvegicus	75-81
30521948-11	2019	Moreover, iron chelator attenuated neuropathic pain and inhibited the over-expression of CXCL10 and CXCR3 in a dose dependent manner.	Iron	10-14	C-X-C motif chemokine ligand 10	Rattus norvegicus	89-95
30521948-13	2019	Exogenous CXCL10 elicited behavioral hypernociceptive state and CXCR3 over-expression in naive rats, which was reversed by the co-administration of iron chelator.	Iron	148-152	C-X-C motif chemokine ligand 10	Rattus norvegicus	10-16
31494282-7	2019	The consequent deficiency of frataxin protein leads to reduced iron-sulfur cluster biogenesis and mitochondrial ATP production, elevated mitochondrial iron, and oxidative stress.	Iron	151-155	frataxin	Homo sapiens	29-37
30521948-14	2019	CONCLUSION: Our findings demonstrated the contribution of spinal abnormal iron accumulation in regulating CXCL10 pathway in the pathogenesis of neuropathic pain.	Iron	74-78	C-X-C motif chemokine ligand 10	Rattus norvegicus	106-112
31784520-0	2019	Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET.	Iron	44-48	aconitase 1	Homo sapiens	65-90
30628326-6	2019	Reducible phosphorus (BD-P) and iron-aluminum-bound phosphorus (NaOH-rP) were reversibly redistributed into weakly adsorbed phosphorus (NH4Cl-P), polyphosphorus/organophosphorous (NaOH-nrP), residual phosphorus (Rest-P), and interstitial water-soluble active phosphorus (SRP).	Iron	32-36	neuropilin 1	Homo sapiens	185-188
31784520-1	2019	Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor.	Iron	61-65	aconitase 1	Homo sapiens	0-25
30628334-2	2019	The characteristics of the Fe0/alginate microsphere was characterized by FT-IR, SEM, BET, and XPS.	Iron	27-30	delta/notch like EGF repeat containing	Homo sapiens	85-88
31784520-1	2019	Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor.	Iron	61-65	aconitase 1	Homo sapiens	27-31
30628334-3	2019	The SEM and BET analyses showed that the Fe0/alginate microsphere had a multilevel porous structure and could adsorb ARB.	Iron	41-44	delta/notch like EGF repeat containing	Homo sapiens	12-15
31784520-2	2019	When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity.	Iron	5-9	aconitase 1	Homo sapiens	29-33
31784520-2	2019	When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity.	Iron	46-50	aconitase 1	Homo sapiens	29-33
31784520-2	2019	When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity.	Iron	46-50	aconitase 1	Homo sapiens	73-77
31784520-3	2019	When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) encoding proteins involved in cellular iron uptake, distribution, and storage.	Iron	5-9	aconitase 1	Homo sapiens	23-27
30728365-1	2019	Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells.	Iron	96-100	transferrin receptor	Homo sapiens	0-22
31784520-3	2019	When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) encoding proteins involved in cellular iron uptake, distribution, and storage.	Iron	5-9	aconitase 1	Homo sapiens	51-55
30728365-1	2019	Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells.	Iron	96-100	transferrin receptor	Homo sapiens	24-28
31784520-3	2019	When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) encoding proteins involved in cellular iron uptake, distribution, and storage.	Iron	70-74	aconitase 1	Homo sapiens	23-27
31784520-3	2019	When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) encoding proteins involved in cellular iron uptake, distribution, and storage.	Iron	70-74	aconitase 1	Homo sapiens	23-27
31784520-6	2019	AGBE binds specifically to holo-IRP1 and to mitoNEET, a protein capable of repairing IRP1 iron-sulphur clusters.	Iron	90-94	aconitase 1	Homo sapiens	85-89
31784520-7	2019	This interaction ensures nuclear translocation of holo-IRP1 and downregulation of iron-dependent processes, demonstrating that holo-IRP1 functions not just as an aconitase, but throttles target gene expression in anticipation of declining iron requirements.	Iron	82-86	aconitase 1	Homo sapiens	132-136
30207798-8	2019	Knockdown of tfR1 and iron-responsive element-binding proteins 2 prevented PA-induced iron uptake and insulin resistance.	Iron	86-90	transferrin receptor	Homo sapiens	13-17
30391537-7	2019	Our findings confirm the role of transferrin receptor in H. pylori attachment into the gastric mucosa to capture iron.	Iron	113-117	transferrin receptor	Homo sapiens	33-53
31784520-7	2019	This interaction ensures nuclear translocation of holo-IRP1 and downregulation of iron-dependent processes, demonstrating that holo-IRP1 functions not just as an aconitase, but throttles target gene expression in anticipation of declining iron requirements.	Iron	239-243	aconitase 1	Homo sapiens	55-59
30207798-11	2019	Blocking iron overload may thus be a useful strategy for preventing insulin resistance and diabetes.-Cui, R., Choi, S.-E., Kim, T. H., Lee, H. J., Lee, S. J., Kang, Y., Jeon, J. Y., Kim, H. J., Lee, K.-W. Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.	Iron	9-13	transferrin receptor	Homo sapiens	222-252
31693344-10	2019	The analysis extends to the coordination abilities of {(H)SNO}, SNO-, and SSNO- into heme and nonheme iron centers, providing a basis for best unraveling their putative specific signaling roles.	Iron	102-106	strawberry notch homolog 1	Homo sapiens	58-61
31542426-13	2019	Moreover, iron deposition up-regulated the expression of AMPK, Beclin1 and LC3 and increase the number of autophagosomes in hippocampus.	Iron	10-14	beclin 1	Rattus norvegicus	63-70
30593976-6	2019	As expected, we also found that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved the activity of several antioxidant enzymes.	Iron	209-213	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	139-143
30593976-6	2019	As expected, we also found that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved the activity of several antioxidant enzymes.	Iron	209-213	transferrin receptor	Mus musculus	149-169
30593976-6	2019	As expected, we also found that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved the activity of several antioxidant enzymes.	Iron	209-213	transferrin receptor	Mus musculus	171-174
30315404-0	2019	Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury.	Iron	98-102	ceruloplasmin	Rattus norvegicus	6-19
30315404-1	2019	Ceruloplasmin (CP) is an essential ferroxidase that is involved in maintaining iron homeostasis by oxidizing toxic ferrous iron (Fe2+) to less-toxic ferric iron (Fe3+).	Iron	79-83	ceruloplasmin	Rattus norvegicus	0-13
30315404-1	2019	Ceruloplasmin (CP) is an essential ferroxidase that is involved in maintaining iron homeostasis by oxidizing toxic ferrous iron (Fe2+) to less-toxic ferric iron (Fe3+).	Iron	79-83	ceruloplasmin	Rattus norvegicus	15-17
30315404-1	2019	Ceruloplasmin (CP) is an essential ferroxidase that is involved in maintaining iron homeostasis by oxidizing toxic ferrous iron (Fe2+) to less-toxic ferric iron (Fe3+).	Iron	123-127	ceruloplasmin	Rattus norvegicus	0-13
30315404-1	2019	Ceruloplasmin (CP) is an essential ferroxidase that is involved in maintaining iron homeostasis by oxidizing toxic ferrous iron (Fe2+) to less-toxic ferric iron (Fe3+).	Iron	123-127	ceruloplasmin	Rattus norvegicus	15-17
29734523-6	2019	Iron and zinc were increased close to recommended levels in polished grains of the transformed lines, with maximum levels when AtNRAMP3, AtNAS1 and PvFER were expressed together (12.67 mug/g DW iron and 45.60 mug/g DW zinc in polished grains of line NFON16).	Iron	0-4	nicotianamine synthase 1	Arabidopsis thaliana	137-143
31678562-0	2019	Bacterial ABC transporters of iron containing compounds.	Iron	30-34	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	10-13
30565864-2	2019	Herein, flexible Fex Oy /nitrogen-doped carbon films (Fex Oy /NC-MOG) are prepared by facile electrospinning of Fe-based metal-organic gels (MOGs) followed by high-temperature carbonization.	Iron	17-19	myelin oligodendrocyte glycoprotein	Homo sapiens	65-68
31542426-13	2019	Moreover, iron deposition up-regulated the expression of AMPK, Beclin1 and LC3 and increase the number of autophagosomes in hippocampus.	Iron	10-14	annexin A3	Rattus norvegicus	75-78
31507082-10	2019	Ferritin heavy chain 1 (FTH1) and transferrin receotor protein 1 (TFR1), both of which are critical for iron metabolism, were markedly up-regulated in HCC cells treated with erastin and sorafenib, whereas knockdown of S1R inhibited these increases.	Iron	104-108	transferrin receptor	Homo sapiens	34-64
30415773-1	2018	BACKGROUND INFORMATION: Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR1) are vital proteins for cellular iron uptake.	Iron	124-128	transferrin receptor	Homo sapiens	64-84
30415773-1	2018	BACKGROUND INFORMATION: Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR1) are vital proteins for cellular iron uptake.	Iron	124-128	transferrin receptor	Homo sapiens	86-90
30415773-3	2018	Besides, iron regulatory protein 1 (IRP1) regulates DMT1 and TfR1 by binding to iron-responsive elements (IREs) present in their mRNAs to control cellular iron homeostasis.	Iron	9-13	aconitase 1	Homo sapiens	36-40
30696910-5	2019	Spatial profiling of TAM iron deposit infiltration defined regions of maximal accumulation and response to the CSF1R inhibitor, and revealed differences between microenvironments of human cancer according to levels of polarized macrophage iron accumulation in stromal margins.	Iron	25-29	colony stimulating factor 1 receptor	Homo sapiens	111-116
30415773-3	2018	Besides, iron regulatory protein 1 (IRP1) regulates DMT1 and TfR1 by binding to iron-responsive elements (IREs) present in their mRNAs to control cellular iron homeostasis.	Iron	9-13	transferrin receptor	Homo sapiens	61-65
31507082-10	2019	Ferritin heavy chain 1 (FTH1) and transferrin receotor protein 1 (TFR1), both of which are critical for iron metabolism, were markedly up-regulated in HCC cells treated with erastin and sorafenib, whereas knockdown of S1R inhibited these increases.	Iron	104-108	transferrin receptor	Homo sapiens	66-70
30415773-3	2018	Besides, iron regulatory protein 1 (IRP1) regulates DMT1 and TfR1 by binding to iron-responsive elements (IREs) present in their mRNAs to control cellular iron homeostasis.	Iron	80-84	aconitase 1	Homo sapiens	9-34
30415773-3	2018	Besides, iron regulatory protein 1 (IRP1) regulates DMT1 and TfR1 by binding to iron-responsive elements (IREs) present in their mRNAs to control cellular iron homeostasis.	Iron	80-84	aconitase 1	Homo sapiens	36-40
30691187-0	2019	Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator Transport HFE Polymorphism on the Human Red Blood Cell Mean Corpuscular Volume (MCV).	Iron	70-74	homeostatic iron regulator	Homo sapiens	95-98
30691187-2	2019	The homeostatic iron regulator HFE (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals.	Iron	16-20	homeostatic iron regulator	Homo sapiens	31-34
30415773-3	2018	Besides, iron regulatory protein 1 (IRP1) regulates DMT1 and TfR1 by binding to iron-responsive elements (IREs) present in their mRNAs to control cellular iron homeostasis.	Iron	80-84	transferrin receptor	Homo sapiens	61-65
30691187-2	2019	The homeostatic iron regulator HFE (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals.	Iron	94-98	homeostatic iron regulator	Homo sapiens	31-34
30415773-5	2018	Ferrous iron uptake was elevated by DMT1(+IRE) and TfR1 under acute hypoxia.	Iron	0-12	transferrin receptor	Homo sapiens	51-55
31076252-10	2019	As iron cannot be completely missing from an organism, we assume that in EPP patients, a certain amount of ALAS2 mRNA is translated despite a partial deficiency of FECH.	Iron	3-7	5'-aminolevulinate synthase 2	Homo sapiens	107-112
30691187-2	2019	The homeostatic iron regulator HFE (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals.	Iron	94-98	homeostatic iron regulator	Homo sapiens	31-34
30691187-3	2019	The aim of our study was to investigate whether the HFE genotype modifies the blood lead levels that affect the distributions of serum iron and other red blood cell indices.	Iron	135-139	homeostatic iron regulator	Homo sapiens	52-55
31097365-10	2019	This could be explained if HCV infection (a): enhanced an oxidative environment in the vicinity of UROD and (b): facilitated iron accumulation through hepdicin down-regulation.	Iron	71-75	uroporphyrinogen decarboxylase	Homo sapiens	99-103
30412371-2	2018	Here, we proposed a novel nanostructured sensor based on the combination of fluorinated graphene oxide and iron-based metal-organic gel (FGO@Fe-MOG).	Iron	107-111	myelin oligodendrocyte glycoprotein	Homo sapiens	144-147
30267477-6	2018	Increased transcription factor EB (TFEB) in T80 (relative to HEY), accompanied by its nuclear translocation and increased CLEAR network gene expression with iron, is identified.	Iron	157-161	transcription factor EB	Homo sapiens	35-39
30670944-9	2018	No difference was seen in transferrin receptor 1 (TfR1) expression, except a small reduction in wildtype mice at 72 h, suggesting that the increase in DMT1 may underlie iron uptake independent of TfR1-endosomal uptake.	Iron	169-173	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	151-155
31456206-4	2019	Iron metabolism mainly depends on iron regulatory proteins including ferritin, transferrin and transferrin receptor, hepcidin, ferroportin, lactoferrin.	Iron	0-4	transferrin receptor	Homo sapiens	95-115
31456206-4	2019	Iron metabolism mainly depends on iron regulatory proteins including ferritin, transferrin and transferrin receptor, hepcidin, ferroportin, lactoferrin.	Iron	34-38	transferrin receptor	Homo sapiens	95-115
31097365-11	2019	Thus, only when iron accumulation reached a threshold, inhibition of UROD attained a critical level.	Iron	16-20	uroporphyrinogen decarboxylase	Homo sapiens	69-73
30636622-5	2019	Evidence is given for the participation of redoxsensitive metals Cu and Fe with PrPsc inducing oxidative stress by disturbing the homeostasis of these metals.	Iron	72-74	prion protein	Mus musculus	80-85
30486249-1	2018	Genetic hemochromatosis is an iron overload disease that is mainly related to the C282Y mutation in the HFE gene.	Iron	30-34	homeostatic iron regulator	Homo sapiens	104-107
31439810-1	2019	The transferrin receptor (TfR1) is the principal means of iron importation for most mammalian cells, and regulation of mRNA stability is a major mechanism through which TfR1 expression is controlled in response to changing intracellular iron levels.	Iron	58-62	transferrin receptor	Homo sapiens	4-24
30991414-11	2019	Thus, in CKD, decreased expression of TfR1 in erythroblasts as well as increased hepcidin levels in circulation may hamper erythroblast differentiation by decreasing the iron supply, as iron is an indispensable component of erythroblast differentiation.	Iron	170-174	transferrin receptor	Mus musculus	38-42
31439810-1	2019	The transferrin receptor (TfR1) is the principal means of iron importation for most mammalian cells, and regulation of mRNA stability is a major mechanism through which TfR1 expression is controlled in response to changing intracellular iron levels.	Iron	58-62	transferrin receptor	Homo sapiens	26-30
30519254-4	2018	Frataxin deficiency affects iron metabolism in both organelles, leading to an impairment of mitochondrial respiration, and chlorophyll and photosynthetic electron transport deficiency in chloroplasts.	Iron	28-32	frataxin	Homo sapiens	0-8
31439810-1	2019	The transferrin receptor (TfR1) is the principal means of iron importation for most mammalian cells, and regulation of mRNA stability is a major mechanism through which TfR1 expression is controlled in response to changing intracellular iron levels.	Iron	237-241	transferrin receptor	Homo sapiens	4-24
31439810-1	2019	The transferrin receptor (TfR1) is the principal means of iron importation for most mammalian cells, and regulation of mRNA stability is a major mechanism through which TfR1 expression is controlled in response to changing intracellular iron levels.	Iron	237-241	transferrin receptor	Homo sapiens	26-30
31439810-1	2019	The transferrin receptor (TfR1) is the principal means of iron importation for most mammalian cells, and regulation of mRNA stability is a major mechanism through which TfR1 expression is controlled in response to changing intracellular iron levels.	Iron	237-241	transferrin receptor	Homo sapiens	169-173
30835340-3	2019	The growing interest of scientists in this issue affects hereditary hemochromatoris (HH), which characterizes by the excess deposition of iron mostly due to HFE gene mutation.	Iron	138-142	homeostatic iron regulator	Homo sapiens	157-160
30584425-6	2018	On the other hand, iron overload increased IL6 and reduced IL10 in small intestinal tissues reflecting inflammatory condition and increased caspase 3 reactivity indicating apoptosis and increased iNOs expressing cell indicting oxidative stress especially in ileum.	Iron	19-23	caspase 3	Rattus norvegicus	140-149
31439810-2	2019	An endonuclease activity degrades the TfR1 mRNA during iron-repletion, which reduces iron importation and contributes to the restoration of homeostasis.	Iron	55-59	transferrin receptor	Homo sapiens	38-42
31439810-2	2019	An endonuclease activity degrades the TfR1 mRNA during iron-repletion, which reduces iron importation and contributes to the restoration of homeostasis.	Iron	85-89	transferrin receptor	Homo sapiens	38-42
31439810-3	2019	Correct identification of the TfR1 mRNA endonuclease activity is important as it has potential to be a pharmacological target for the treatment of several pathologies in which iron homeostasis is perturbed.	Iron	176-180	transferrin receptor	Homo sapiens	30-34
31439810-4	2019	A recent RNA article identified both miR-7-5p and miR-141-3p as mediators of TfR1 mRNA degradation during iron-repletion.	Iron	106-110	transferrin receptor	Homo sapiens	77-81
31439810-9	2019	As a result, it is unlikely that the microRNAs are directly mediating iron-responsive degradation of the TfR1 mRNA as recently proposed.	Iron	70-74	transferrin receptor	Homo sapiens	105-109
30662597-5	2018	Among them, an iron-containing gene, PolE, the catalytic subunit of DNA polymerase epsilon (Polepsilon), and the other two Polepsilon subunits, including PolE2 and PolE3, were markedly downregulated, while some proteins involved in apoptosis such as Caspase-3 and -8 were significantly upregulated.	Iron	15-19	DNA polymerase epsilon 3, accessory subunit	Homo sapiens	164-169
31465624-1	2019	We report the characterization of an S= 1 / 2  iron pi-complex, [Fe(eta6 -IndH)(depe)]+ (Ind=Indenide (C9 H7 - ), depe=1,2-bis(diethylphosphino)ethane), which results via C-H elimination from a transient FeIII hydride, [Fe(eta3 :eta2 -Ind)(depe)H]+ .	Iron	47-51	DNA polymerase iota	Homo sapiens	229-233
30362717-0	2018	Spectroscopic and Electronic Structure Study of ETHE1: Elucidating the Factors Influencing Sulfur Oxidation and Oxygenation in Mononuclear Nonheme Iron Enzymes.	Iron	147-151	ETHE1 persulfide dioxygenase	Homo sapiens	48-53
31203124-8	2019	Iron-rich acidic soil had a high dissolution of Ag2S-NPs ranging from 47.1% to 61.7% in porewater.	Iron	0-4	angiotensin II receptor type 1	Homo sapiens	48-52
30383537-4	2018	Specifically, Fe stimulated the expression of mPGES-1 and the production of PGE2 and PGD2 via the Tf and TfR system.	Iron	14-16	transferrin receptor	Mus musculus	105-108
31636772-1	2019	This paper outlines the Danish aspects of HFE-hemochromatosis, which is the most frequent genetic predisposition to iron overload in the five million ethnic Danes; more than 20,000 people are homozygous for the C282Y mutation and more than 500,000 people are compound heterozygous or heterozygous for the HFE-mutations.	Iron	116-120	homeostatic iron regulator	Homo sapiens	42-45
30141226-5	2018	Depending on the applied P(R)3 , the iron carbonyl species were finally converted into [Fe2 (CO)6 (mu-CO){mu-P(R)2 }]- .	Iron	37-41	proteinase 3	Homo sapiens	25-30
31511419-2	2019	FXN has been shown to be necessary for iron-sulfur (Fe-S) cluster biosynthesis and proper mitochondrial function.	Iron	52-56	frataxin	Homo sapiens	0-3
31511419-3	2019	The structural and functional core of the Fe-S cluster assembly complex is a low-activity pyridoxal 5"-phosphate (PLP)-dependent cysteine desulfurase enzyme that consists of catalytic (NFS1), LYRM protein (ISD11), and acyl carrier protein (ACP) subunits.	Iron	42-46	NFS1 cysteine desulfurase	Homo sapiens	185-189
31565359-3	2019	Mechanical milling is used to produce uniform red mud nanoparticles, which are rich in hematite (Fe2O3), and lower amounts of other metal oxides.	Iron	97-102	adaptor related protein complex 5 subunit mu 1	Homo sapiens	50-53
31511419-8	2019	Our resulting architectural switch model explains why the human Fe-S assembly system has low inherent activity and requires activation, the connection between the functional mobile S-transfer loop cysteine and FXN binding, and why the prokaryotic system does not require a similar FXN-based activation.	Iron	64-68	frataxin	Homo sapiens	210-213
30190412-0	2018	The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells.	Iron	56-60	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	4-32
31511419-8	2019	Our resulting architectural switch model explains why the human Fe-S assembly system has low inherent activity and requires activation, the connection between the functional mobile S-transfer loop cysteine and FXN binding, and why the prokaryotic system does not require a similar FXN-based activation.	Iron	64-68	frataxin	Homo sapiens	281-284
30190412-0	2018	The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells.	Iron	56-60	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	34-38
30190412-1	2018	The divalent metal transporter 1 (DMT1) is a multimetal transporter with a primary role in iron transport.	Iron	91-95	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	4-32
31486461-11	2019	Further, analysis of the electron density distribution and local density of states indicates that Mg2+ ions can act as insulating defects in the lattice framework that render certain Fe ions electrically inactive and likely contribute to capacity fade along with dissolution of Fe(CN)63-.	Iron	183-185	mucin 7, secreted	Homo sapiens	98-101
30190412-1	2018	The divalent metal transporter 1 (DMT1) is a multimetal transporter with a primary role in iron transport.	Iron	91-95	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	34-38
30190412-8	2018	These results indicate that DMT1 is vital for OPC maturation and for the normal myelination of the mouse brain.SIGNIFICANCE STATEMENT To determine whether divalent metal transporter 1 (DMT1), a multimetal transporter with a primary role in iron transport, is essential for oligodendrocyte development, we created two conditional knock-out mice in which DMT1 was postnatally deleted in NG2- or Sox10-positive oligodendrocyte progenitor cells (OPCs).	Iron	240-244	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	185-189
30190412-8	2018	These results indicate that DMT1 is vital for OPC maturation and for the normal myelination of the mouse brain.SIGNIFICANCE STATEMENT To determine whether divalent metal transporter 1 (DMT1), a multimetal transporter with a primary role in iron transport, is essential for oligodendrocyte development, we created two conditional knock-out mice in which DMT1 was postnatally deleted in NG2- or Sox10-positive oligodendrocyte progenitor cells (OPCs).	Iron	240-244	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	185-189
30277764-2	2018	By exploiting X-ray and ultraviolet photoelectron spectroscopy combined with an electrochemical cell (EC-XPS/UPS), we can electrochemically control the Fc SAMs and spectroscopically probe the induced changes with the ferrocene/ferrocenium (Fc/Fc+) redox center (Fe oxidation state), formation of 1:1 Fc+-ClO4- ion pairs, molecular orientation, and monolayer thickness.	Iron	262-264	methionine adenosyltransferase 1A	Homo sapiens	155-159
31486461-11	2019	Further, analysis of the electron density distribution and local density of states indicates that Mg2+ ions can act as insulating defects in the lattice framework that render certain Fe ions electrically inactive and likely contribute to capacity fade along with dissolution of Fe(CN)63-.	Iron	278-280	mucin 7, secreted	Homo sapiens	98-101
31511561-0	2019	Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function.	Iron	113-117	ATP binding cassette subfamily B member 7	Rattus norvegicus	86-91
29718108-8	2018	This in silico study showed that LAM was able to bind directly to the heme iron in the active site of CYP17A1, but not CYP21A2, thus supporting the results of the in vitro studies.	Iron	75-79	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	102-109
31209948-1	2019	Frataxin (FXN) is a highly conserved protein found in prokaryotes and eukaryotes that is required for efficient regulation of cellular iron homeostasis.	Iron	135-139	frataxin	Homo sapiens	0-8
30059941-1	2018	BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism.	Iron	20-24	homeostatic iron regulator	Homo sapiens	113-116
31209948-1	2019	Frataxin (FXN) is a highly conserved protein found in prokaryotes and eukaryotes that is required for efficient regulation of cellular iron homeostasis.	Iron	135-139	frataxin	Homo sapiens	10-13
31443397-0	2019	HFE Related Hemochromatosis: Uncovering the Inextricable Link between Iron Homeostasis and the Immunological System.	Iron	70-74	homeostatic iron regulator	Homo sapiens	0-3
30204426-3	2018	In vitro studies using apo-ferredoxin (FDX) reveal that mNT uses an Fe-based redox switch mechanism to regulate the transfer of its cluster.	Iron	68-70	max binding protein	Mus musculus	56-59
31443397-5	2019	We were challenged by the finding of iron overload in a 9-year-old boy homozygous for the C282Y HFE variant, with two brothers aged 11 and 5 also homozygous for the mutation.	Iron	37-41	homeostatic iron regulator	Homo sapiens	96-99
31434871-7	2019	Interestingly, in FAC-exposed FTSECs, EVI1 siRNA attenuated hTERT mRNA expression, whereas siRNAs targeting beta-catenin and BMI1 (both elevated with chronic iron exposure) reduced Myc and Cyclin D1 proteins.	Iron	158-162	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	125-129
30333913-1	2018	The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment.	Iron	56-60	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	41-44
30254659-0	2018	A Shoot Fe Signaling Pathway Requiring the OPT3 Transporter Controls GSNO Reductase and Ethylene in Arabidopsis thaliana Roots.	Iron	8-10	oligopeptide transporter	Arabidopsis thaliana	43-47
30254659-7	2018	The opt3-2 mutant is impaired in the loading of shoot Fe into the phloem and presents constitutive expression of Fe acquisition genes.	Iron	54-56	oligopeptide transporter	Arabidopsis thaliana	4-8
31395877-0	2019	Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin.	Iron	43-47	frataxin	Homo sapiens	137-145
30254659-7	2018	The opt3-2 mutant is impaired in the loading of shoot Fe into the phloem and presents constitutive expression of Fe acquisition genes.	Iron	113-115	oligopeptide transporter	Arabidopsis thaliana	4-8
30254659-10	2018	Additionally, Fe-sufficient opt3-2 roots had higher "ethylene" and "GSNOR" than Fe-sufficient WT Columbia roots.	Iron	14-16	oligopeptide transporter	Arabidopsis thaliana	28-32
30254659-10	2018	Additionally, Fe-sufficient opt3-2 roots had higher "ethylene" and "GSNOR" than Fe-sufficient WT Columbia roots.	Iron	80-82	oligopeptide transporter	Arabidopsis thaliana	28-32
30060949-3	2018	Compared with wild-type (WT) mice, Heph/Cp mice at both ages presented with severe anemia and significantly lower iron level in the serum and spleen, but with significantly higher iron level in the liver, heart, kidney, and duodenal enterocytes.	Iron	114-118	hephaestin	Mus musculus	35-39
31395877-1	2019	Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects lead to severe diseases among which is Friedreich"s ataxia caused by impaired expression of frataxin (FXN).	Iron	13-17	frataxin	Homo sapiens	179-187
30060949-3	2018	Compared with wild-type (WT) mice, Heph/Cp mice at both ages presented with severe anemia and significantly lower iron level in the serum and spleen, but with significantly higher iron level in the liver, heart, kidney, and duodenal enterocytes.	Iron	180-184	hephaestin	Mus musculus	35-39
30060949-6	2018	Together, our results suggest that ablation of HEPH and CP could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions.	Iron	89-93	hephaestin	Mus musculus	47-51
31395877-1	2019	Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects lead to severe diseases among which is Friedreich"s ataxia caused by impaired expression of frataxin (FXN).	Iron	13-17	frataxin	Homo sapiens	189-192
30060949-6	2018	Together, our results suggest that ablation of HEPH and CP could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions.	Iron	122-126	hephaestin	Mus musculus	47-51
31395877-2	2019	Fe-S clusters are biosynthesized on the scaffold protein ISCU, with cysteine desulfurase NFS1 providing sulfur as persulfide and ferredoxin FDX2 supplying electrons, in a process stimulated by FXN but not clearly understood.	Iron	0-4	NFS1 cysteine desulfurase	Homo sapiens	89-93
31395877-2	2019	Fe-S clusters are biosynthesized on the scaffold protein ISCU, with cysteine desulfurase NFS1 providing sulfur as persulfide and ferredoxin FDX2 supplying electrons, in a process stimulated by FXN but not clearly understood.	Iron	0-4	frataxin	Homo sapiens	193-196
31395877-4	2019	By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters.	Iron	27-31	NFS1 cysteine desulfurase	Homo sapiens	62-66
31044416-0	2019	Could haemochromatosis (HFE) gene mutations affect response to iron chelation in myelodysplastic syndrome?	Iron	63-67	homeostatic iron regulator	Homo sapiens	24-27
30195758-2	2018	The frataxin protein, encoded by that gene, plays an important role in mitochondria"s iron metabolism.	Iron	86-90	frataxin	Homo sapiens	4-12
31044418-0	2019	Could haemochromatosis (HFE) gene mutations affect response to iron chelation in myelodysplastic syndrome?	Iron	63-67	homeostatic iron regulator	Homo sapiens	24-27
30177808-7	2018	Iron increased Caspase 9, Cytochrome c, APAF1, Caspase 3 and cleaved PARP, without affecting cleaved Caspase 8 levels.	Iron	0-4	apoptotic peptidase activating factor 1	Rattus norvegicus	40-45
30177808-7	2018	Iron increased Caspase 9, Cytochrome c, APAF1, Caspase 3 and cleaved PARP, without affecting cleaved Caspase 8 levels.	Iron	0-4	caspase 3	Rattus norvegicus	47-56
31088860-7	2019	Loss of PRPF40B in K562 induces a KLF1 transcriptional signature, with genes involved in iron metabolism and mainly hypoxia, including related pathways like cholesterol biosynthesis and Akt/MAPK signaling.	Iron	89-93	Kruppel like factor 1	Homo sapiens	34-38
30177808-8	2018	CBD reversed iron-induced effects, recovering apoptotic proteins Caspase 9, APAF1, Caspase 3 and cleaved PARP to the levels found in controls.	Iron	13-17	apoptotic peptidase activating factor 1	Rattus norvegicus	76-81
30177808-8	2018	CBD reversed iron-induced effects, recovering apoptotic proteins Caspase 9, APAF1, Caspase 3 and cleaved PARP to the levels found in controls.	Iron	13-17	caspase 3	Rattus norvegicus	83-92
31404236-7	2019	Here, we show that ferritin is expressed in adult Drosophila brain and that iron and holoferritin accumulate with aging.	Iron	76-80	Ferritin 1 heavy chain homologue	Drosophila melanogaster	19-27
29777905-8	2018	Iron-depletion additionally reduced 3H-spermidine uptake in direct agreement with the lowered levels of the polyamine importer, SLC22A16.	Iron	0-4	solute carrier family 22 member 16	Homo sapiens	128-136
29777905-9	2018	Regarding mechanism, the "reprogramming" of polyamine metabolism by iron-depletion is consistent with the down-regulation of ADI1 and MAT2alpha, and the up-regulation of SAT1.	Iron	68-72	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	170-174
29777905-10	2018	Moreover, changes in ADI1 (biosynthetic) and SAT1 (catabolic) partially depended on the iron-regulated changes in c-Myc and/or p53.	Iron	88-92	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	45-49
30342981-7	2019	In addition, iron could increase the mRNA levels of alpha-synuclein via iron responsive element/iron regulatory protein (IRE/IRP) system.	Iron	13-17	Wnt family member 2	Homo sapiens	125-128
30342981-7	2019	In addition, iron could increase the mRNA levels of alpha-synuclein via iron responsive element/iron regulatory protein (IRE/IRP) system.	Iron	72-76	Wnt family member 2	Homo sapiens	125-128
31241124-7	2019	These results suggested an important role of AMPK in regulating iron nanoparticle-associated neurotoxicity.	Iron	64-68	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	45-49
31722347-6	2019	MHT using Fe-line induced pronounced autophagy, decrease of myosin heavy chain content, and increase in serum HMGB1.	Iron	10-12	high mobility group box 1	Mus musculus	110-115
31939159-4	2019	Additionally, laborious studies concerning the enzymatic reactions involved have allowed for understanding the capability of frataxin to modulate Fe-S cluster assembly function.	Iron	146-150	frataxin	Homo sapiens	125-133
29775905-3	2018	Whereas bio-electrolysis reactor system (C-EL) Iron Scraps amended yield lesser methane (51.2 ml/g COD) in comparison to control bio-electrolysis reactor system without Iron scraps (C-CONT - 114.4 ml/g COD).	Iron	47-51	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	99-102
31372038-3	2019	Transferrin receptor 1 (TfR1) is a key regulator of cellular iron homeostasis.	Iron	61-65	transferrin receptor	Homo sapiens	0-22
29906559-0	2018	Peroxiredoxin 5 prevents iron overload-induced neuronal death by inhibiting mitochondrial fragmentation and endoplasmic reticulum stress in mouse hippocampal HT-22 cells.	Iron	25-29	peroxiredoxin 5	Mus musculus	0-15
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	36-40	peroxiredoxin 5	Mus musculus	121-136
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	36-40	peroxiredoxin 5	Mus musculus	138-142
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	187-191	peroxiredoxin 5	Mus musculus	121-136
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	187-191	peroxiredoxin 5	Mus musculus	138-142
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	187-191	peroxiredoxin 5	Mus musculus	121-136
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	187-191	peroxiredoxin 5	Mus musculus	138-142
29906559-5	2018	Moreover, Prx5 also prevented iron overload-induced ER-stress and cleavage of caspase-3, which consequently attenuated neuronal cell death.	Iron	30-34	peroxiredoxin 5	Mus musculus	10-14
29906559-7	2018	So we thought that this study is essential for understanding iron toxicity in neurons, and Prx5 may serve as a new therapeutic target to prevent iron overload-induced diseases and neurodegenerative disorders.	Iron	145-149	peroxiredoxin 5	Mus musculus	91-95
30596656-1	2018	The bloodstream form of the parasite Trypanosoma brucei obtains iron from its mammalian host by receptor-mediated endocytosis of host transferrin through its own unique transferrin receptor (TbTfR).	Iron	64-68	transferrin receptor	Homo sapiens	169-189
30219725-0	2018	N-(aminobutyl)-N-(ethylisoluminol) functionalized Fe-based metal-organic frameworks with intrinsic mimic peroxidase activity for sensitive electrochemiluminescence mucin1 determination.	Iron	50-52	mucin 1, cell surface associated	Homo sapiens	164-170
30219725-1	2018	Herein, N-(4-aminobutyl)-N-(ethylisoluminol) functionalized Fe-based metal-organic frameworks (ABEI/MIL-101(Fe)) with intrinsic mimic peroxidase activity was synthesized and utilized as highly efficient ECL indicator to construct sensitive immunosensor for mucin1 (MUC1) detection.	Iron	60-62	C-C motif chemokine ligand 21	Homo sapiens	203-206
30219725-1	2018	Herein, N-(4-aminobutyl)-N-(ethylisoluminol) functionalized Fe-based metal-organic frameworks (ABEI/MIL-101(Fe)) with intrinsic mimic peroxidase activity was synthesized and utilized as highly efficient ECL indicator to construct sensitive immunosensor for mucin1 (MUC1) detection.	Iron	60-62	mucin 1, cell surface associated	Homo sapiens	257-263
30219725-1	2018	Herein, N-(4-aminobutyl)-N-(ethylisoluminol) functionalized Fe-based metal-organic frameworks (ABEI/MIL-101(Fe)) with intrinsic mimic peroxidase activity was synthesized and utilized as highly efficient ECL indicator to construct sensitive immunosensor for mucin1 (MUC1) detection.	Iron	60-62	mucin 1, cell surface associated	Homo sapiens	265-269
30219725-4	2018	It is worth noting that the ECL signal of ABEI/MIL-101(Fe) could be greatly heightened due to the intrinsic mimic peroxidase activity of ABEI/MIL-101(Fe) that could accelerate the decomposition of H2O2 and produce considerable numbers of reactive oxygen radicals to participate in the ECL reaction of ABEI.	Iron	55-57	C-C motif chemokine ligand 21	Homo sapiens	28-31
30219725-4	2018	It is worth noting that the ECL signal of ABEI/MIL-101(Fe) could be greatly heightened due to the intrinsic mimic peroxidase activity of ABEI/MIL-101(Fe) that could accelerate the decomposition of H2O2 and produce considerable numbers of reactive oxygen radicals to participate in the ECL reaction of ABEI.	Iron	55-57	C-C motif chemokine ligand 21	Homo sapiens	285-288
30219725-4	2018	It is worth noting that the ECL signal of ABEI/MIL-101(Fe) could be greatly heightened due to the intrinsic mimic peroxidase activity of ABEI/MIL-101(Fe) that could accelerate the decomposition of H2O2 and produce considerable numbers of reactive oxygen radicals to participate in the ECL reaction of ABEI.	Iron	150-152	C-C motif chemokine ligand 21	Homo sapiens	28-31
30219725-4	2018	It is worth noting that the ECL signal of ABEI/MIL-101(Fe) could be greatly heightened due to the intrinsic mimic peroxidase activity of ABEI/MIL-101(Fe) that could accelerate the decomposition of H2O2 and produce considerable numbers of reactive oxygen radicals to participate in the ECL reaction of ABEI.	Iron	150-152	C-C motif chemokine ligand 21	Homo sapiens	285-288
30100261-4	2018	PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, which leads to the HIF1A-dependent Warburg effect and AIM2-dependent inflammasome activation in tumor cells.	Iron	90-94	absent in melanoma 2	Mus musculus	163-167
31372038-3	2019	Transferrin receptor 1 (TfR1) is a key regulator of cellular iron homeostasis.	Iron	61-65	transferrin receptor	Homo sapiens	24-28
30952001-1	2019	In this study, g-C3N4/PDI/Fe (gCPF) composite material was prepared by incorporating Fe ion on the composite catalyst of g-C3N4/PDI (gCP).	Iron	26-28	prolyl 4-hydroxylase subunit beta	Homo sapiens	22-25
29897731-4	2018	The tfr2 mutant model in zebrafish recapitulates the defining features of HH3: iron overload and suppression of hepcidin, the iron regulatory hormone.	Iron	79-83	transferrin receptor 2	Danio rerio	4-8
30253349-2	2018	The novel bio-nanocomposite of chitosan/activated carbon/iron nanoparticles was synthesized via the sonochemical method and characterized using FTIR, SEM, and BET techniques.	Iron	57-61	delta/notch like EGF repeat containing	Homo sapiens	159-162
31098737-6	2019	Consequently, SOD2 expression emerges as a potential biomarker of PH in SCD being a link among hemolysis, inflammation, iron overload, oxidative stress, and SCD cardiopathy.	Iron	120-124	superoxide dismutase 2	Homo sapiens	14-18
30501637-0	2018	Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model.	Iron	33-37	lipocalin 2	Mus musculus	0-11
30501637-9	2018	CONCLUSIONS: Lcn2 contributes to AD-like brain iron dysregulation, and future research should further explore the importance of Lcn2 in AD.	Iron	47-51	lipocalin 2	Mus musculus	13-17
29983374-1	2018	Cysteine desulfurase plays a central role in mitochondrial iron-sulfur cluster biogenesis by generating sulfur through the conversion of L-cysteine to L-alanine and by serving as the platform for assembling other components of the biosynthetic machinery, including ISCU, frataxin, and ferredoxin.	Iron	59-63	frataxin	Homo sapiens	271-279
29870742-8	2018	In concordance with ameliorated splicing of SIRT1, lipin-1, and Srsf3, knockdown of hepatic Slu7 inhibited the activity of NF-kappaB, normalized iron and zinc homeostasis, reduced oxidative stress, and attenuated liver damage in ethanol-fed mice.	Iron	145-149	SLU7 splicing factor homolog (S. cerevisiae)	Mus musculus	92-96
30809369-0	2019	A Golgi-targeting fluorescent probe for labile Fe(ii) to reveal an abnormal cellular iron distribution induced by dysfunction of VPS35.	Iron	85-89	VPS35 retromer complex component	Homo sapiens	129-134
31198069-6	2019	GCLC protein levels were correlated with serum iron.	Iron	47-51	glutamate-cysteine ligase catalytic subunit	Homo sapiens	0-4
30381188-3	2018	Two genes were identified whose deletion resulted in sensitivity to EGCG: FET3 and FTR1, encoding the components of the Fet3/Ftr1 high-affinity iron uptake system, also involved in Cu(I)/Cu(II) balance on the surface of yeast cells.	Iron	144-148	ferroxidase FET3	Saccharomyces cerevisiae S288C	74-78
30381188-3	2018	Two genes were identified whose deletion resulted in sensitivity to EGCG: FET3 and FTR1, encoding the components of the Fet3/Ftr1 high-affinity iron uptake system, also involved in Cu(I)/Cu(II) balance on the surface of yeast cells.	Iron	144-148	ferroxidase FET3	Saccharomyces cerevisiae S288C	120-124
29702192-7	2018	The increased iron activated Nox4, which resulted in overproduction of H2O2 and lipid peroxides.	Iron	14-18	NADPH oxidase 4	Homo sapiens	29-33
30002810-5	2018	Iron homeostatic proteins including iron response protein 1 (IRP1), transferrin (Tf), ferritin and transferrin receptor (TfR) were determined by using western blotting and immunohistochemistry, and their relative expression levels of RNA were measured by RT-PCR in both N171-82Q HD transgenic mice and HEK293 cells expressing N-terminal of huntingtin.	Iron	0-4	transferrin receptor	Mus musculus	121-124
30914277-11	2019	MAPKs were activated after ferrous iron treatment, and inhibitors of ERK and p38-MAPK relieved AQP4 expression upregulation as well as astrocyte death.	Iron	27-39	mitogen-activated protein kinase 14	Mus musculus	77-80
30361722-0	2018	Identifying macrophage enrichment in atherosclerotic plaques by targeting dual-modal US imaging/MRI based on biodegradable Fe-doped hollow silica nanospheres conjugated with anti-CD68 antibody.	Iron	123-125	CD68 antigen	Mus musculus	179-183
29417224-10	2018	Gelatin zymography showed dietary iron restriction decreased both renal MMP-2 and MMP-9 activities in SHR-SP at 15 weeks old.	Iron	34-38	matrix metallopeptidase 2	Rattus norvegicus	72-77
31086870-6	2019	To better understand the Mn import pathway in skeletal muscle cells, we probed the functional relevance of the closely related proteins ZIP8 and ZIP14, which are implicated in Zn, Mn, and Fe transport.	Iron	188-190	solute carrier family 39 member 8	Homo sapiens	136-140
29417224-12	2018	Furthermore, dietary iron restriction decreased renal fibrosis, renal MMP-2 and MMP-9 activities, renal TGFbeta-RI expression, and Smad2 phosphorylation in rats with unilateral ureteral obstruction.	Iron	21-25	matrix metallopeptidase 2	Rattus norvegicus	70-75
29778670-1	2018	Iron is a component of many proteins that have crucial roles in plant growth and development, such as ferritin and catalase.	Iron	0-4	catalase-3	Glycine max	115-123
30310908-5	2018	Meanwhile, the absorbing percentage of BMG-Fe for Cr3+ is 96.36%, indicating a high separation rate.	Iron	43-45	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	50-53
29968489-1	2018	Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants.	Iron	111-115	homeostatic iron regulator	Homo sapiens	124-127
31086870-6	2019	To better understand the Mn import pathway in skeletal muscle cells, we probed the functional relevance of the closely related proteins ZIP8 and ZIP14, which are implicated in Zn, Mn, and Fe transport.	Iron	188-190	solute carrier family 39 member 14	Homo sapiens	145-150
29968489-4	2018	Increased cellular mtDNA content may represent a compensatory response to mitochondrial stress that is influenced by iron-loading HFE variants.	Iron	117-121	homeostatic iron regulator	Homo sapiens	130-133
31088072-5	2019	In addition, we found that the inhibition by this class of polyphenolic compounds on ALKBH2 is through an iron-chelating mechanism.	Iron	106-110	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	85-91
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	33-37	transferrin receptor	Mus musculus	120-131
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	33-37	transferrin receptor	Mus musculus	133-136
31312077-1	2019	Human Ceruloplasmin (hCP) is an unique multicopper oxidase which involves in different biological functions e.g., iron metabolism, copper transportation, biogenic amine oxidation ,and its malfunction causes Wilson"s and Menkes diseases.	Iron	114-118	alpha-1-microglobulin/bikunin precursor	Homo sapiens	21-24
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	87-91	transferrin receptor	Mus musculus	120-131
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	87-91	transferrin receptor	Mus musculus	133-136
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	97-99	transferrin receptor	Mus musculus	120-131
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	97-99	transferrin receptor	Mus musculus	133-136
30344693-7	2018	Blood samples collected from certain members of this pedigree were subjected to whole-exome sequencing, and three genetic variants were identified, including a missense variant of solute carrier family 4 member 1 (SLC4A1) (c.388G&gt;A), a deletion on glycoprotein Ib platelet alpha subunit (GP1BA) (c.1322_1344del23) and an insertion in the splice site of homeostatic iron regulator (HFE).	Iron	368-372	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	214-220
29677391-0	2018	A FIT-binding protein is involved in modulating iron and zinc homeostasis in Arabidopsis.	Iron	48-52	Inositol monophosphatase family protein	Arabidopsis thaliana	2-21
29677391-5	2018	Physiological analyses reveal that the mutant fbp retains a larger amount of Zn in roots and transfers a greater proportion of Fe to shoots than that in wild type under Zn-excessive stress.	Iron	127-129	Inositol monophosphatase family protein	Arabidopsis thaliana	46-49
29872815-8	2018	The Fe overload increased the anti-inflammatory cytokines together with IL-1beta and IP-10.	Iron	4-6	C-X-C motif chemokine 10	Capra hircus	85-90
31196213-11	2019	In addition, higher fat integrity, more viable adipocytes, more CD31-positive blood vessels, fewer apoptotic cells and more Ki67-positive proliferating cells were observed in the nanofat- and FE-treated groups.	Iron	192-194	platelet and endothelial cell adhesion molecule 1	Homo sapiens	64-68
29921869-7	2018	In CKD, iron deposition associated with increased intensity of iron importers (ZIP14, ZIP8), storage proteins (L-, H-ferritin), and/or decreased ferroportin abundance.	Iron	8-12	solute carrier family 39 member 14	Homo sapiens	79-84
29921869-7	2018	In CKD, iron deposition associated with increased intensity of iron importers (ZIP14, ZIP8), storage proteins (L-, H-ferritin), and/or decreased ferroportin abundance.	Iron	8-12	solute carrier family 39 member 8	Homo sapiens	86-90
30348310-4	2018	The side of the root apparatus exposed to combined S and Fe deficiency, showed an over induction of the FeIII-reducing capacity (+40%) and of the expression levels of the gene codifying for this protein (SlFRO1), with respect to the Fe-deficient part of the root system.	Iron	57-59	ferric-chelate reductase	Solanum lycopersicum	204-210
30092986-2	2018	According to UV-vis diffuse reflectance spectroscopy (UV-vis/DRS) characterization, the photocatalytic activity of WO3 nanoparticles could be improved by doping with Fe impurity.	Iron	166-168	sushi repeat containing protein X-linked	Homo sapiens	61-64
30975898-1	2019	In humans, mitochondrial iron-sulfur cluster biosynthesis is an essential biochemical process mediated by the assembly complex consisting of cysteine desulfurase (NFS1), LYR protein (ISD11), acyl-carrier protein (ACP), and the iron-sulfur cluster assembly scaffold protein (ISCU2).	Iron	25-29	NFS1 cysteine desulfurase	Homo sapiens	163-167
29498084-0	2018	RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of beta-thalassemia intermedia.	Iron	75-79	transmembrane serine protease 6	Mus musculus	35-42
29498084-3	2018	Expression of the iron regulatory peptide hormone hepcidin is repressed by the serine protease TMPRSS6.	Iron	18-22	transmembrane serine protease 6	Mus musculus	95-102
30027360-8	2018	In addition, significantly up-regulated expression of FtH and FtL mRNA, and markedly down-regulated expression of Tfr1, Dmt1 + IRE and Ireg1 mRNA, were observed in the iron overload group compared with the control group.	Iron	168-172	transferrin receptor	Rattus norvegicus	114-118
30975898-2	2019	The protein frataxin (FXN) is an allosteric activator that binds the assembly complex and stimulates the cysteine desulfurase and iron-sulfur cluster assembly activities.	Iron	130-134	frataxin	Homo sapiens	12-20
29498084-4	2018	Hepcidin induction by RNAi-mediated inhibition of TMPRSS6 expression reduces iron overload and mitigates anemia in murine models of beta-thalassemia intermedia.	Iron	77-81	transmembrane serine protease 6	Mus musculus	50-57
30975898-2	2019	The protein frataxin (FXN) is an allosteric activator that binds the assembly complex and stimulates the cysteine desulfurase and iron-sulfur cluster assembly activities.	Iron	130-134	frataxin	Homo sapiens	22-25
30975898-3	2019	FXN depletion causes loss of activity of iron-sulfur-dependent enzymes and the development of the neurodegenerative disease Friedreich"s ataxia.	Iron	41-45	frataxin	Homo sapiens	0-3
30975898-5	2019	Here, we developed iron-sulfur cluster synthesis and transfer functional assays and determined that the human ISCU2 M140I variant can substitute for FXN in accelerating the rate of iron-sulfur cluster formation on the monothiol glutaredoxin (GRX5) acceptor protein.	Iron	181-185	frataxin	Homo sapiens	149-152
29935032-12	2018	CONCLUSION: In elderly men, we showed a nonlinear association of tE2 and fE2 with all-cause mortality.	Iron	73-76	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	65-68
30975898-5	2019	Here, we developed iron-sulfur cluster synthesis and transfer functional assays and determined that the human ISCU2 M140I variant can substitute for FXN in accelerating the rate of iron-sulfur cluster formation on the monothiol glutaredoxin (GRX5) acceptor protein.	Iron	181-185	glutaredoxin	Homo sapiens	228-240
30059941-1	2018	BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism.	Iron	72-76	homeostatic iron regulator	Homo sapiens	113-116
30059941-1	2018	BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism.	Iron	72-76	homeostatic iron regulator	Homo sapiens	124-127
30034931-7	2018	TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells.	Iron	55-59	transferrin receptor	Homo sapiens	0-4
30034931-7	2018	TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells.	Iron	94-98	transferrin receptor	Homo sapiens	0-4
30975898-6	2019	Incorporation of both FXN and the M140I substitution had an additive effect, suggesting an acceleration of distinct steps in iron-sulfur cluster biogenesis.	Iron	125-129	frataxin	Homo sapiens	22-25
30975898-7	2019	In contrast to the canonical role of FXN in stimulating the formation of [2Fe-2S]-ISCU2 intermediates, we found here that the M140I substitution in ISCU2 promotes the transfer of iron-sulfur clusters to GRX5.	Iron	179-183	frataxin	Homo sapiens	37-40
30707893-8	2019	The results were as follows: TfR1 (iron uptake protein) expression was decreased, the expression of ferritin heavy chain and light chain (iron storage protein) was increased.	Iron	35-39	transferrin receptor	Homo sapiens	29-33
29404719-5	2018	In multivariate linear regression models, iron status was found to be associated with hepcidin levels in infants with wild-type HFE gene (p = 0.046 and p = 0.048 in 6- and 12-month-olds, respectively).	Iron	42-46	homeostatic iron regulator	Homo sapiens	128-131
29859760-6	2018	In addition, abundant expression of PrPC, a ferrireductase that facilitates iron transport, is noted in pigmented and non-pigmented epithelium of the CB, posterior pigmented epithelium of the iris, corneal endothelium and epithelium, and lens epithelium.	Iron	76-80	prion protein	Mus musculus	36-40
29859760-7	2018	Notably, majority of PrPC in the ciliary epithelium is cleaved at the beta-site as in retinal pigment epithelial cells, suggesting a role in iron transport.	Iron	141-145	prion protein	Mus musculus	21-25
31213851-0	2019	Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway.	Iron	63-67	transferrin receptor	Homo sapiens	40-44
29903757-5	2018	In the present study, we show that iron overload impairs the frequency and colony-forming capacity of normal hematopoietic stem and progenitor cells, especially in erythroid, in MDS mice, which is due, at least in part, to growth differentiation factor 11-induced reactive oxygen species, shortening survival of MDS mice.	Iron	35-39	growth differentiation factor 11	Mus musculus	223-255
31213851-8	2019	Moreover, both TfR1 and DMT1 expressed on cell membrane were involved in high iron uptake in TNBCs under DFO-induced iron deficient condition.	Iron	78-82	transferrin receptor	Homo sapiens	15-19
29627385-8	2018	Interestingly, Mga2 also activates the transcription of its own mRNA in response to iron deficiency, hypoxia, low temperature and low UFAs.	Iron	84-88	Mga2p	Saccharomyces cerevisiae S288C	15-19
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	66-70	transferrin receptor	Homo sapiens	96-100
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	132-136	transferrin receptor	Homo sapiens	96-100
29215791-6	2018	Ex vivo cell analysis of C57BL/6 mice showed that CI treatment reduced the proportion of proinflammatory F4/80+ CD40+ M1 macrophages and activated T lymphocytes in the spleen.	Iron	50-52	CD40 antigen	Mus musculus	112-116
30051477-2	2018	We showed the role of iron in cisplatin-induced nephrotoxicity that entrance to the cell via transferrin receptor (TfR) as a gatekeeper for iron uptake.	Iron	22-26	transferrin receptor	Rattus norvegicus	115-118
30051477-2	2018	We showed the role of iron in cisplatin-induced nephrotoxicity that entrance to the cell via transferrin receptor (TfR) as a gatekeeper for iron uptake.	Iron	140-144	transferrin receptor	Rattus norvegicus	115-118
31017428-7	2019	Combining coordination and oxidation modulation allows the synthesis of pristine MIL-126(Fe) with BET surface areas close to the predicted maximum for the first time, suggesting that combining the two may be a powerful methodology for the controlled self-assembly of high-valent MOFs.	Iron	89-91	delta/notch like EGF repeat containing	Homo sapiens	98-101
30051477-10	2018	CONCLUSIONS: The results supported a role for iron in cisplatin-induced nephrotoxicity and TfR may serve as an important source of iron.	Iron	131-135	transferrin receptor	Rattus norvegicus	91-94
29575577-2	2018	We generated and characterized hepatocyte-specific Smad7 knockout mice (Smad7Alb/Alb ), which showed decreased serum iron, tissue iron, haemoglobin concentration, up-regulated hepcidin and increased phosphor-Smad1/5/8 levels in both isolated primary hepatocytes and liver tissues.	Iron	130-134	SMAD family member 7	Mus musculus	51-56
29575577-2	2018	We generated and characterized hepatocyte-specific Smad7 knockout mice (Smad7Alb/Alb ), which showed decreased serum iron, tissue iron, haemoglobin concentration, up-regulated hepcidin and increased phosphor-Smad1/5/8 levels in both isolated primary hepatocytes and liver tissues.	Iron	130-134	albumin	Mus musculus	72-84
31137574-0	2019	Inhibitory Mechanisms of DHA/CQ on pH and Iron Homeostasis of Erythrocytic Stage Growth of Plasmodium Falciparum.	Iron	42-46	dha/cq	None	25-31
29576242-0	2018	Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.	Iron	16-20	frataxin	Homo sapiens	27-35
29576242-0	2018	Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.	Iron	108-112	frataxin	Homo sapiens	27-35
29576242-1	2018	Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation.	Iron	57-61	frataxin	Homo sapiens	0-8
29576242-1	2018	Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation.	Iron	57-61	frataxin	Homo sapiens	10-13
29576242-1	2018	Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation.	Iron	107-111	frataxin	Homo sapiens	0-8
29576242-1	2018	Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation.	Iron	107-111	frataxin	Homo sapiens	10-13
29520929-1	2018	The OLIGOPEPTIDE TRANSPORTER 3 (OPT3) has recently been identified as a component of the systemic network mediating iron (Fe) deficiency responses in Arabidopsis.	Iron	116-120	oligopeptide transporter	Arabidopsis thaliana	4-30
29520929-1	2018	The OLIGOPEPTIDE TRANSPORTER 3 (OPT3) has recently been identified as a component of the systemic network mediating iron (Fe) deficiency responses in Arabidopsis.	Iron	116-120	oligopeptide transporter	Arabidopsis thaliana	32-36
29520929-1	2018	The OLIGOPEPTIDE TRANSPORTER 3 (OPT3) has recently been identified as a component of the systemic network mediating iron (Fe) deficiency responses in Arabidopsis.	Iron	122-124	oligopeptide transporter	Arabidopsis thaliana	4-30
29520929-1	2018	The OLIGOPEPTIDE TRANSPORTER 3 (OPT3) has recently been identified as a component of the systemic network mediating iron (Fe) deficiency responses in Arabidopsis.	Iron	122-124	oligopeptide transporter	Arabidopsis thaliana	32-36
29520929-2	2018	Reduced expression of OPT3 induces an over accumulation of Fe in roots and leaves, due in part by an elevated expression of the IRON-REGULATED TRANSPORTER 1.	Iron	59-61	oligopeptide transporter	Arabidopsis thaliana	22-26
29520929-3	2018	Here we show however, that opt3 leaves display a transcriptional program consistent with an Fe overload, suggesting that Fe excess is properly sensed in opt3 leaves and that the OPT3-mediated shoot-to-root signaling is critical to prevent a systemic Fe overload.	Iron	92-94	oligopeptide transporter	Arabidopsis thaliana	27-31
29520929-3	2018	Here we show however, that opt3 leaves display a transcriptional program consistent with an Fe overload, suggesting that Fe excess is properly sensed in opt3 leaves and that the OPT3-mediated shoot-to-root signaling is critical to prevent a systemic Fe overload.	Iron	92-94	oligopeptide transporter	Arabidopsis thaliana	178-182
29520929-3	2018	Here we show however, that opt3 leaves display a transcriptional program consistent with an Fe overload, suggesting that Fe excess is properly sensed in opt3 leaves and that the OPT3-mediated shoot-to-root signaling is critical to prevent a systemic Fe overload.	Iron	121-123	oligopeptide transporter	Arabidopsis thaliana	27-31
29420779-0	2018	The mitochondrial ABC transporter Atm1 plays a role in iron metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.	Iron	55-59	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	34-38
29420779-9	2018	Overall, our results demonstrated that Atm1 plays a critical role in iron metabolism and virulence for C. neoformans.	Iron	69-73	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	39-43
29520929-3	2018	Here we show however, that opt3 leaves display a transcriptional program consistent with an Fe overload, suggesting that Fe excess is properly sensed in opt3 leaves and that the OPT3-mediated shoot-to-root signaling is critical to prevent a systemic Fe overload.	Iron	121-123	oligopeptide transporter	Arabidopsis thaliana	27-31
31023660-8	2019	GJA1 variants should be considered in patients with hereditary spastic paraplegia presenting with brain hypomyelination, especially if associated with neurodegeneration and a brain iron accumulation pattern.	Iron	181-185	gap junction protein alpha 1	Homo sapiens	0-4
30077971-2	2018	X-ray structural features have suggested that CcO pumps protons via a mechanism involving electrostatic repulsions between pumping protons in the hydrogen-bond network of a proton-conducting pathway (the H-pathway) and net positive charges created upon oxidation of an iron site, heme a (Fe a2+), for reduction of O2 at another iron site, heme a3 (Fe a32+).	Iron	269-273	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	46-49
30077971-2	2018	X-ray structural features have suggested that CcO pumps protons via a mechanism involving electrostatic repulsions between pumping protons in the hydrogen-bond network of a proton-conducting pathway (the H-pathway) and net positive charges created upon oxidation of an iron site, heme a (Fe a2+), for reduction of O2 at another iron site, heme a3 (Fe a32+).	Iron	288-290	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	46-49
29774235-1	2018	The two most important magmatic differentiation series on Earth are the Fe-enriching tholeiitic series, which dominates the oceanic crust and island arcs, and the Fe-depleting calc-alkaline series, which dominates the continental crust and continental arcs.	Iron	163-165	mitochondrial calcium uptake 1	Homo sapiens	176-180
30077971-2	2018	X-ray structural features have suggested that CcO pumps protons via a mechanism involving electrostatic repulsions between pumping protons in the hydrogen-bond network of a proton-conducting pathway (the H-pathway) and net positive charges created upon oxidation of an iron site, heme a (Fe a2+), for reduction of O2 at another iron site, heme a3 (Fe a32+).	Iron	328-332	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	46-49
28874056-9	2018	INNOVATION: CP alterations in iron contents were mediated through DMT1(-IRE) and changes in ROS levels, which in turn attenuated the progression of AD through the Erk/p38 and Bcl-2/Bax signaling pathways.	Iron	30-34	mitogen-activated protein kinase 14	Mus musculus	167-170
30831243-1	2019	Transferrin (TF), an iron-binding multifunctional protein, could participate in the iron-withholding strategy, an effective antimicrobial defense mechanism in innate immunity, and is involved in host defense against pathogenic infection.	Iron	21-25	serotransferrin-like	Oreochromis niloticus	0-11
29373036-7	2018	Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1beta and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3-/- livers.	Iron	173-177	matrix metallopeptidase 13	Mus musculus	35-39
29373036-7	2018	Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1beta and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3-/- livers.	Iron	173-177	matrix metallopeptidase 12	Mus musculus	41-47
29373036-7	2018	Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1beta and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3-/- livers.	Iron	173-177	matrix metallopeptidase 13	Mus musculus	52-58
30250736-2	2018	Residual feed intake (RFI) is a measure of FE that is independent of level of production.	Iron	43-45	RFI	Bos taurus	22-25
30137082-10	2018	We rescued the high iron sensitivity conferred by the AFT1 alleles by deleting the sphingolipid signaling kinase YPK1.	Iron	20-24	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	113-117
30137082-11	2018	We observed that the deletion of YPK1 exerts different effects on iron accumulation depending on the AFT1 allele and the environmental iron.	Iron	66-70	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	33-37
30831243-1	2019	Transferrin (TF), an iron-binding multifunctional protein, could participate in the iron-withholding strategy, an effective antimicrobial defense mechanism in innate immunity, and is involved in host defense against pathogenic infection.	Iron	21-25	serotransferrin-like	Oreochromis niloticus	13-15
30137082-11	2018	We observed that the deletion of YPK1 exerts different effects on iron accumulation depending on the AFT1 allele and the environmental iron.	Iron	124-128	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	33-37
30831243-1	2019	Transferrin (TF), an iron-binding multifunctional protein, could participate in the iron-withholding strategy, an effective antimicrobial defense mechanism in innate immunity, and is involved in host defense against pathogenic infection.	Iron	84-88	serotransferrin-like	Oreochromis niloticus	0-11
30831243-1	2019	Transferrin (TF), an iron-binding multifunctional protein, could participate in the iron-withholding strategy, an effective antimicrobial defense mechanism in innate immunity, and is involved in host defense against pathogenic infection.	Iron	84-88	serotransferrin-like	Oreochromis niloticus	13-15
29659799-3	2018	Using the Miller assay it was determined that under low iron availability exposure to sub-inhibitory doses of hepcidin (4-12muM) led to 2-fold and 4-fold increases in the expression of ftnA and bfd, respectively (P &lt; 0.05), in both a wild type (WT) and Deltafur (ferric uptake regulator) background.	Iron	56-60	ADAM metallopeptidase domain 1A (pseudogene)	Homo sapiens	185-189
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	CD14 molecule	Homo sapiens	107-111
29452354-5	2018	We discovered that alpha-syn expression phenocopies the high iron condition: under the low iron condition (<1 microM), alpha-syn inhibits Snx3-retromer-mediated recycling of Fet3/Ftr1 and instead shunts Fet3/Ftr1 into the multivesicular body pathway to the vacuole.	Iron	91-95	ferroxidase FET3	Saccharomyces cerevisiae S288C	174-178
30235822-4	2018	Many evidences indicate that frataxin deficiency causes the deregulation of cellular iron homeostasis.	Iron	85-89	frataxin	Homo sapiens	29-37
30235822-5	2018	In this review, we will discuss several hypotheses proposed for frataxin function, their caveats, and how they could provide an explanation for the deregulation of iron homeostasis found in frataxin-deficient cells.	Iron	164-168	frataxin	Homo sapiens	190-198
30277616-5	2018	Our findings indicate that iron impaction to corneal tissue results in cleavage of 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 variant (PLCB2; 134 kDa) into a 36 kDa species and presence of the epithelial layer is necessary for this cleavage.	Iron	27-31	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	141-147
30835899-6	2019	Furthermore, iron loading of macrophages in the presence of IL-4 led to the down-regulation of M2 markers: arginase-1, Mgl-1, and M2-specific transcriptional regulator, KLF4.	Iron	13-17	arginase 1	Homo sapiens	107-117
30835899-11	2019	Furthermore, NAFLD patients with hepatic RES iron deposition had increased hepatic gene expression levels of M1 markers, IL-6, IL-1beta, and CD40 and reduced gene expression of an M2 marker, TGM2, relative to patients with hepatocellular iron deposition pattern.	Iron	45-49	CD40 molecule	Homo sapiens	141-145
29407213-0	2018	Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain.	Iron	0-4	noggin	Homo sapiens	41-47
29407213-7	2018	Under normal conditions, noggin CM induced myelin production with an increase in ferritin levels in MO3.13, which was reversed by the iron chelator, deferoxamine.	Iron	134-138	noggin	Homo sapiens	25-31
31028253-5	2019	It is highly sensitive and allows the detection of an iron concentration of 263 pmolFe ml-1, which is one of the lowest iron concentrations imaged by MPI so far.	Iron	54-58	interleukin 17F	Homo sapiens	87-91
29407213-8	2018	These results indicated that noggin altered the iron status in reactive microglia from the iron-storing to the iron-releasing phenotype, which contributed to myelin synthesis by providing iron.	Iron	48-52	noggin	Homo sapiens	29-35
29407213-8	2018	These results indicated that noggin altered the iron status in reactive microglia from the iron-storing to the iron-releasing phenotype, which contributed to myelin synthesis by providing iron.	Iron	91-95	noggin	Homo sapiens	29-35
29407213-8	2018	These results indicated that noggin altered the iron status in reactive microglia from the iron-storing to the iron-releasing phenotype, which contributed to myelin synthesis by providing iron.	Iron	91-95	noggin	Homo sapiens	29-35
29407213-8	2018	These results indicated that noggin altered the iron status in reactive microglia from the iron-storing to the iron-releasing phenotype, which contributed to myelin synthesis by providing iron.	Iron	91-95	noggin	Homo sapiens	29-35
29626156-10	2018	This mechanism adjusts the uptake of iron to the needs of amino acid biosynthesis and expands the list of Gcn4-independent activities of the Gcn2-eIF2alpha regulatory system.	Iron	37-41	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	106-110
30016142-12	2018	CT-based liver fat content was underestimated in several patients with iron overload.	Iron	71-75	FAT atypical cadherin 1	Homo sapiens	15-18
29859963-9	2018	Iron attenuated forskolin-mediated induction of the key gluconeogenic enzyme, glucose-6-phosphatase.	Iron	0-4	glucose-6-phosphatase, catalytic	Mus musculus	78-99
31028253-5	2019	It is highly sensitive and allows the detection of an iron concentration of 263 pmolFe ml-1, which is one of the lowest iron concentrations imaged by MPI so far.	Iron	120-124	interleukin 17F	Homo sapiens	87-91
29700330-8	2018	Peripheral challenge with glucose and insulin revealed blunting of the response in iron-overloaded PrP+/+ relative to PrP-/- mice, suggesting that PrPC-mediated modulation of IC iron influences both secretion and sensitivity of peripheral organs to insulin.	Iron	83-87	prion protein	Mus musculus	99-102
33273745-0	2019	Genetics, crystallization sequence, and age of the South Byron Trio iron meteorites: New insights to carbonaceous chondrite (CC) type parent bodies.	Iron	68-72	trio Rho guanine nucleotide exchange factor	Homo sapiens	63-67
29700330-8	2018	Peripheral challenge with glucose and insulin revealed blunting of the response in iron-overloaded PrP+/+ relative to PrP-/- mice, suggesting that PrPC-mediated modulation of IC iron influences both secretion and sensitivity of peripheral organs to insulin.	Iron	83-87	prion protein	Mus musculus	147-151
29700330-8	2018	Peripheral challenge with glucose and insulin revealed blunting of the response in iron-overloaded PrP+/+ relative to PrP-/- mice, suggesting that PrPC-mediated modulation of IC iron influences both secretion and sensitivity of peripheral organs to insulin.	Iron	178-182	prion protein	Mus musculus	99-102
29700330-8	2018	Peripheral challenge with glucose and insulin revealed blunting of the response in iron-overloaded PrP+/+ relative to PrP-/- mice, suggesting that PrPC-mediated modulation of IC iron influences both secretion and sensitivity of peripheral organs to insulin.	Iron	178-182	prion protein	Mus musculus	147-151
33273745-1	2019	The nucleosynthetic Mo, Ru, and W isotopic compositions of the South Byron Trio iron meteorite grouplet (SBT) are consistent with all three meteorites originating on a single parent body that formed in the carbonaceous chondrite (CC) isotopic domain within the Solar nebula.	Iron	80-84	trio Rho guanine nucleotide exchange factor	Homo sapiens	75-79
29475949-5	2018	Steady-state levels of Cytb are close to wildtype in mutant D273-10b cells, and Cytb forms non-functional, supercomplex-like species with cytochrome c oxidase, in which at least core 1, cytochrome c1, and Rieske iron-sulfur subunits are present.	Iron	212-216	cytochrome b	Saccharomyces cerevisiae S288C	80-84
30667570-4	2019	As a proof-of-concept, the Fe-doped carbon electrocatalysts realized a Pt/C-like half-wave potential of 0.869 V vs. RHE and small Tafel slope of 51.3 mV dec-1 in oxygen reduction reaction.	Iron	27-29	deleted in esophageal cancer 1	Homo sapiens	153-158
29649237-7	2018	The ex vivo finding was confirmed by the induction of iron-dependent ROS generation and chemokine/cytokine overexpression of Ccl4, Cxcl10 (M1), Il1rn (M2), Cxcl2, and Cxcl7 (MTPP) in MH-S murine immortalized alveolar macrophages exposed to ferric ammonium citrate in culture (p-value&lt;0.05 vs CTR).	Iron	54-58	pro-platelet basic protein	Mus musculus	167-172
33395787-1	2019	To provide superior substrates and determine the specific species of immobilized nano zero-valent iron (NZVI) system, polyacrylonitrile (PAN) membrane was functionalized by bio-inspired polydopamine (PDA) and poly(l-DOPA) (PDOPA) for efficient immobilization of NZVI.	Iron	98-102	adenosine deaminase 2	Homo sapiens	137-140
33395787-3	2019	Analyses of XRD, SEM/EDS and XPS show that the aggregation and release of iron nanoparticles had been successfully controlled by improving membrane hydrophilcity and iron-chelating capacity via the graft of functionalized groups (i.e. OH and COOH) of PDA and PDOPA on PAN membrane.	Iron	74-78	adenosine deaminase 2	Homo sapiens	268-271
30370692-6	2019	We also provide evidence that under uninflamed conditions, the regulation of Fpn1 and TfR1 expression by H 2 S, both in vivo and in vitro, are mediated by the nitric oxide (NO)/Nrf2 and iron regulatory protein/iron responsive element pathways, respectively, which are independent of IL-6/pSTAT3/hepcidin signals.	Iron	186-190	transferrin receptor	Mus musculus	86-90
30370692-6	2019	We also provide evidence that under uninflamed conditions, the regulation of Fpn1 and TfR1 expression by H 2 S, both in vivo and in vitro, are mediated by the nitric oxide (NO)/Nrf2 and iron regulatory protein/iron responsive element pathways, respectively, which are independent of IL-6/pSTAT3/hepcidin signals.	Iron	210-214	transferrin receptor	Mus musculus	86-90
30635474-3	2019	Frataxin localizes to the mitochondrial matrix and is required for iron-sulfur-cluster biosynthesis.	Iron	67-71	frataxin	Homo sapiens	0-8
29634759-2	2018	Lack of iron, a critical component of heme and hemoglobin, activates Heme Regulated Inhibitor (HRI).	Iron	8-12	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	69-93
29634759-2	2018	Lack of iron, a critical component of heme and hemoglobin, activates Heme Regulated Inhibitor (HRI).	Iron	8-12	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	95-98
29329987-2	2018	It is known that frataxin-deficiency leads to alterations in cellular and mitochondrial iron metabolism and impacts in the cell physiology at several levels.	Iron	88-92	frataxin	Homo sapiens	17-25
29329987-3	2018	Frataxin is thought to play a role in iron-sulfur cluster biogenesis and heme synthesis.	Iron	38-42	frataxin	Homo sapiens	0-8
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	36-40	transferrin receptor	Homo sapiens	145-165
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	36-40	transferrin receptor	Homo sapiens	168-171
31950689-0	2018	In Situ Decoration of Znx Cd1-x S with FeP for Efficient Photocatalytic Generation of Hydrogen under Irradiation with Visible Light.	Iron	39-42	CD1c molecule	Homo sapiens	26-29
31950689-1	2018	FeP as a noble-metal-free catalyst has been successfully decorated onto the Znx Cd1-x S photocatalyst surface through an in situ phosphating process.	Iron	0-3	CD1c molecule	Homo sapiens	80-83
29244196-9	2018	Additionally, iron overload induced G1arrest in MC3T3-E1 cells and down-regulated the expression of Cyclin D1 , Cyclin D3 , CDK2, CDK4 and CDK6, but up-regulated p27 Kip1.	Iron	14-18	cyclin D3	Mus musculus	112-121
29244196-9	2018	Additionally, iron overload induced G1arrest in MC3T3-E1 cells and down-regulated the expression of Cyclin D1 , Cyclin D3 , CDK2, CDK4 and CDK6, but up-regulated p27 Kip1.	Iron	14-18	cyclin-dependent kinase 6	Mus musculus	139-143
29244196-14	2018	These results show that iron overload generates ROS, blocks the PI3K/AKT and Jak/Stat3 signal pathways, and activates p38 MAPK, subsequently inducing G1 arrest and autophagy in MC3T3-E1 cells.	Iron	24-28	mitogen-activated protein kinase 14	Mus musculus	118-121
30080593-5	2018	DN-bHLH101 plants showed a significant phenotype that was sensitive to a methylviologen treatment, even under iron-sufficient conditions.	Iron	110-114	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-10
29373688-13	2018	Conclusions: Our study uncovers epigenetic regulation of VHL and its functional consequences for altered oxygen and iron homeostasis in preeclampsia.	Iron	116-120	von Hippel-Lindau tumor suppressor	Homo sapiens	57-60
29364516-9	2018	Furthermore, iron decreased the expression of nuclear transcription factor EB (TFEB), a master transcriptional regulator of autophagosome-lysosome fusion, and inhibited its nuclear translocation through activating AKT/mTORC1 signaling.	Iron	13-17	CREB regulated transcription coactivator 1	Mus musculus	218-224
30635474-4	2019	Decreased expression of frataxin is associated with mitochondrial dysfunction, mitochondrial iron accumulation, and increased oxidative stress.	Iron	93-97	frataxin	Homo sapiens	24-32
29295890-1	2018	Intracellular iron is tightly regulated by coordinated expression of iron transport and storage genes, such as transferrin receptor-1 (TfR1) and ferritin.	Iron	14-18	transferrin receptor	Homo sapiens	111-133
30604643-1	2019	Targeting transferrin receptor 1 (TfR1) with monoclonal antibodies is a promising therapeutic strategy in cancer as tumor cells often overexpress TfR1 and show increased iron needs.	Iron	170-174	transferrin receptor	Homo sapiens	10-32
29295890-1	2018	Intracellular iron is tightly regulated by coordinated expression of iron transport and storage genes, such as transferrin receptor-1 (TfR1) and ferritin.	Iron	14-18	transferrin receptor	Homo sapiens	135-139
29295890-1	2018	Intracellular iron is tightly regulated by coordinated expression of iron transport and storage genes, such as transferrin receptor-1 (TfR1) and ferritin.	Iron	69-73	transferrin receptor	Homo sapiens	111-133
29295890-1	2018	Intracellular iron is tightly regulated by coordinated expression of iron transport and storage genes, such as transferrin receptor-1 (TfR1) and ferritin.	Iron	69-73	transferrin receptor	Homo sapiens	135-139
29295890-3	2018	Thus high iron decreases iron transport via TfR1 mRNA degradation and increases iron storage via ferritin translational up-regulation.	Iron	10-14	transferrin receptor	Homo sapiens	44-48
29295890-4	2018	However, the molecular mechanism of TfR1 mRNA destabilization in response to iron remains elusive.	Iron	77-81	transferrin receptor	Homo sapiens	36-40
29295890-6	2018	Conversely, miR-7-5p and miR-141-3p antagomiRs partially but significantly blocked iron- or IRP knockdown-induced down-regulation of TfR1 mRNA, suggesting the interplay between these microRNAs and IRPs along with involvement of another uncharacterized mechanism in TfR1 mRNA degradation.	Iron	83-87	transferrin receptor	Homo sapiens	133-137
29295890-6	2018	Conversely, miR-7-5p and miR-141-3p antagomiRs partially but significantly blocked iron- or IRP knockdown-induced down-regulation of TfR1 mRNA, suggesting the interplay between these microRNAs and IRPs along with involvement of another uncharacterized mechanism in TfR1 mRNA degradation.	Iron	83-87	transferrin receptor	Homo sapiens	265-269
30604643-1	2019	Targeting transferrin receptor 1 (TfR1) with monoclonal antibodies is a promising therapeutic strategy in cancer as tumor cells often overexpress TfR1 and show increased iron needs.	Iron	170-174	transferrin receptor	Homo sapiens	34-38
29406711-1	2018	Whereas iron-sulfur (Fe-S) cluster assembly on the wild-type scaffold protein ISCU, as catalyzed by the human cysteine desulfurase complex (NIA)2, exhibits a requirement for frataxin (FXN), in yeast, ISCU variant M108I has been shown to bypass the FXN requirement.	Iron	21-25	frataxin	Homo sapiens	174-182
30604643-3	2019	We selected the more promising candidate (H7), based on its ability to inhibit TfR1-mediated iron-loaded transferrin internalization in Raji cells (B-cell lymphoma).	Iron	93-97	transferrin receptor	Homo sapiens	79-83
29406711-1	2018	Whereas iron-sulfur (Fe-S) cluster assembly on the wild-type scaffold protein ISCU, as catalyzed by the human cysteine desulfurase complex (NIA)2, exhibits a requirement for frataxin (FXN), in yeast, ISCU variant M108I has been shown to bypass the FXN requirement.	Iron	21-25	frataxin	Homo sapiens	184-187
29406711-1	2018	Whereas iron-sulfur (Fe-S) cluster assembly on the wild-type scaffold protein ISCU, as catalyzed by the human cysteine desulfurase complex (NIA)2, exhibits a requirement for frataxin (FXN), in yeast, ISCU variant M108I has been shown to bypass the FXN requirement.	Iron	21-25	frataxin	Homo sapiens	248-251
30967894-5	2019	NR2F6 and TGFB1 were identified and validated by motif discovery as key regulators of hepatic inflammatory response and muscle tissue development, respectively, two biological processes demonstrated to be associated with FE.	Iron	221-223	transforming growth factor beta 1	Bos taurus	10-15
29032941-7	2018	NCOA4 activity also exhibited developmental regulation and regulation by cellular iron levels.	Iron	82-86	nuclear receptor coactivator 4	Mus musculus	0-5
30586625-8	2019	IRE-IRP interaction was affected due to conversion of IRP1 to cytosolic aconitase that was influenced by increased iron-sulfur scaffold protein iron-sulfur cluster assembly enzyme (ISCU) level.	Iron	115-119	Wnt family member 2	Homo sapiens	4-7
29032941-8	2018	Excess iron uptake during differentiation triggered lysosomal degradation of NCOA4, which was dependent on the E3 ubiquitin ligase HERC2.	Iron	7-11	nuclear receptor coactivator 4	Mus musculus	77-82
30586625-8	2019	IRE-IRP interaction was affected due to conversion of IRP1 to cytosolic aconitase that was influenced by increased iron-sulfur scaffold protein iron-sulfur cluster assembly enzyme (ISCU) level.	Iron	115-119	aconitase 1	Homo sapiens	54-58
30776286-4	2019	Decreased hepcidin expression increased iron absorption by upregulating transferrin receptor 1 (TfR1) and divalent metal transporter 1 (DMT1) expression, resulting in iron accumulation within cells.	Iron	40-44	transferrin receptor	Mus musculus	96-100
29437953-1	2018	Solute carrier family 39, member 14 (SLC39A14) is a transmembrane transporter that can mediate the cellular uptake of zinc, iron, and manganese (Mn).	Iron	124-128	solute carrier family 39 (zinc transporter), member 14	Mus musculus	37-45
29437953-2	2018	Studies of Slc39a14 knockout (Slc39a14-/-) mice have documented that SLC39A14 is required for systemic growth, hepatic zinc uptake during inflammation, and iron loading of the liver in iron overload.	Iron	156-160	solute carrier family 39 (zinc transporter), member 14	Mus musculus	69-77
29437953-2	2018	Studies of Slc39a14 knockout (Slc39a14-/-) mice have documented that SLC39A14 is required for systemic growth, hepatic zinc uptake during inflammation, and iron loading of the liver in iron overload.	Iron	185-189	solute carrier family 39 (zinc transporter), member 14	Mus musculus	69-77
30776286-4	2019	Decreased hepcidin expression increased iron absorption by upregulating transferrin receptor 1 (TfR1) and divalent metal transporter 1 (DMT1) expression, resulting in iron accumulation within cells.	Iron	167-171	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	136-140
30053508-11	2019	In addition, HIF-2alpha translation is controlled by iron regulatory protein (IRP) activity, providing another level of interdependence between iron and oxygen homeostasis.	Iron	53-57	Wnt family member 2	Homo sapiens	78-81
29414908-2	2018	For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was proposed; the resulting ferrous-peroxynitrate species was not detected, but its decay product, the high-valent ferryl form, was demonstrated in stopped-flow experiments.	Iron	57-61	myoglobin	Bos taurus	4-13
30075191-6	2019	A better understanding of the connection between cigarette smoke, iron, and respiratory diseases will help to elucidate pathogenic mechanisms and aid in the identification of novel therapeutic targets.	Iron	66-70	activation induced cytidine deaminase	Homo sapiens	146-149
29101239-9	2018	Dietary iron repletion completely reversed ID anemia and ineffective erythropoiesis of Hri-/- , eAA, and Atf4-/- mice by inhibiting both HRI and mTORC1 signaling.	Iron	8-12	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	87-90
29260183-7	2018	The inhibition of DMT1/Nramp2 and siRNA knockdown of Nramp1 each reduced the transfer of 59Fe from lysosomes to the cytosol; and hepatocyte-specific knockout of DMT1 in mice prevented the release of Fe from the liver responding to EPO treatment, but did not inhibit lysosomal ferritin degradation.	Iron	91-93	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	23-29
29260183-7	2018	The inhibition of DMT1/Nramp2 and siRNA knockdown of Nramp1 each reduced the transfer of 59Fe from lysosomes to the cytosol; and hepatocyte-specific knockout of DMT1 in mice prevented the release of Fe from the liver responding to EPO treatment, but did not inhibit lysosomal ferritin degradation.	Iron	91-93	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	161-165
30107217-4	2019	Intracellular iron in cardiomyocytes is controlled in part by the iron regulatory proteins IRP1/2.	Iron	14-18	aconitase 1	Homo sapiens	91-97
30107217-4	2019	Intracellular iron in cardiomyocytes is controlled in part by the iron regulatory proteins IRP1/2.	Iron	66-70	aconitase 1	Homo sapiens	91-97
29473051-0	2018	AP4 deficiency: A novel form of neurodegeneration with brain iron accumulation?	Iron	61-65	transcription factor AP-4	Homo sapiens	0-3
30218771-0	2019	Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase.	Iron	23-27	Wnt family member 2	Homo sapiens	70-73
30218771-0	2019	Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase.	Iron	40-44	Wnt family member 2	Homo sapiens	70-73
30860476-3	2019	In the present study, we analysed the interaction between two genes related with iron metabolism - HFE and haptoglobin - and the plasmatic concentration of glutathione, as a way to evaluate the antioxidant response capacity in obesity.	Iron	81-85	homeostatic iron regulator	Homo sapiens	99-102
29342155-5	2018	FRDA is an autosomal recessive disorder with dysregulation of iron metabolism as a key feature.	Iron	62-66	frataxin	Homo sapiens	0-4
29342155-9	2018	This finding might underscore metal dysregulation, beyond iron, in cells derived from FRDA patients.	Iron	58-62	frataxin	Homo sapiens	86-90
32257088-6	2019	After 5 days of Fe deficiency, the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione reductase and ascorbate peroxidase) were significantly higher than in plants supplied with Fe in the absence or presence of Cd.	Iron	16-18	glutathione-disulfide reductase	Homo sapiens	106-127
29259115-0	2018	Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.	Iron	78-82	spen family transcriptional repressor	Homo sapiens	46-50
29259115-6	2018	However, like its counterparts, our biological studies indicate that knockdown of MiNT leads to increased accumulation of mitochondrial labile iron, as well as increased mitochondrial reactive oxygen production.	Iron	143-147	spen family transcriptional repressor	Homo sapiens	82-86
29948914-11	2019	Iron elevated MSC cell ROS level and NOX4 protein expression.	Iron	0-4	NADPH oxidase 4	Mus musculus	37-41
29191452-6	2018	Additionally, significant positive correlation between Fe levels in the head of the flies with negative geotaxis RS and AChE activity in the head of the flies has been found.	Iron	55-57	Acetylcholine esterase	Drosophila melanogaster	120-124
30207798-0	2019	Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.	Iron	0-4	transferrin receptor	Homo sapiens	17-47
29225034-4	2018	Overexpression or knockout of MAGE-F1 altered Fe-S incorporation into MMS19-dependent DNA repair enzymes, DNA repair capacity, sensitivity to DNA-damaging agents, and iron homeostasis.	Iron	46-50	MAGE family member F1	Homo sapiens	30-37
30207798-7	2019	PA up-regulated transferrin receptor 1 (tfR1), an iron uptake protein, which was modulated by iron-responsive element-binding proteins 2.	Iron	50-54	transferrin receptor	Homo sapiens	16-38
30234111-4	2018	Herein, we describe the first reported role of MyD88 in an interconnection between innate immunity and the iron-sensing pathway (BMP/SMAD4).	Iron	107-111	MYD88 innate immune signal transduction adaptor	Homo sapiens	47-52
30207798-7	2019	PA up-regulated transferrin receptor 1 (tfR1), an iron uptake protein, which was modulated by iron-responsive element-binding proteins 2.	Iron	50-54	transferrin receptor	Homo sapiens	40-44
30234111-4	2018	Herein, we describe the first reported role of MyD88 in an interconnection between innate immunity and the iron-sensing pathway (BMP/SMAD4).	Iron	107-111	SMAD family member 4	Homo sapiens	133-138
30207798-7	2019	PA up-regulated transferrin receptor 1 (tfR1), an iron uptake protein, which was modulated by iron-responsive element-binding proteins 2.	Iron	94-98	transferrin receptor	Homo sapiens	16-38
29241202-2	2018	We hypothesized that fasting may be able to affect iron metabolism via ghrelin under the physiological conditions.	Iron	51-55	ghrelin	Mus musculus	71-78
30207798-7	2019	PA up-regulated transferrin receptor 1 (tfR1), an iron uptake protein, which was modulated by iron-responsive element-binding proteins 2.	Iron	94-98	transferrin receptor	Homo sapiens	40-44
29241202-5	2018	Correlation analysis demonstrated that total ghrelin or acylated ghrelin is negatively correlated with iron in the serum in human and mice.	Iron	103-107	ghrelin	Mus musculus	45-52
29241202-5	2018	Correlation analysis demonstrated that total ghrelin or acylated ghrelin is negatively correlated with iron in the serum in human and mice.	Iron	103-107	ghrelin	Mus musculus	65-72
30234111-10	2018	Finally, we report that the MyD88 gain-of-function L265P mutation, frequently encountered in B-cell lymphomas such as Waldenstrom"s macroglobulinemia, enhances hepcidin expression and iron accumulation in B cell lines.	Iron	184-188	MYD88 innate immune signal transduction adaptor	Homo sapiens	28-33
30234111-11	2018	Our results reveal a new potential role for MyD88 in the SMAD signaling pathway and iron homeostasis regulation.	Iron	84-88	MYD88 innate immune signal transduction adaptor	Homo sapiens	44-49
29241202-6	2018	CONCLUSION: Ghrelin has a role to reduce serum iron under the conditions of fasting.	Iron	47-51	ghrelin	Mus musculus	12-19
30510168-2	2019	Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling.	Iron	77-81	SMAD family member 1	Homo sapiens	163-167
28793778-0	2018	Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.	Iron	38-42	peroxiredoxin 2	Mus musculus	0-15
30096922-3	2018	Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR).	Iron	10-14	transferrin receptor	Homo sapiens	80-100
30692166-6	2019	At the cellular level, the major process redundantly regulated by EPS15 and EPS15L1 is the endocytosis of the transferrin receptor, a pathway that sustains the development of red blood cells and controls iron homeostasis.	Iron	204-208	epidermal growth factor receptor pathway substrate 15	Mus musculus	66-71
29966105-2	2018	Mutations in the HFE gene lead to excess iron absorption.	Iron	41-45	homeostatic iron regulator	Homo sapiens	17-20
28793778-7	2018	In Prx2-/- mice, the loss of Hamp response was also observed after administration of a single dose of oral iron.	Iron	107-111	peroxiredoxin 2	Mus musculus	3-7
28793778-12	2018	CONCLUSION: Collectively, our data highlight a novel role of Prx2 in iron homeostasis.	Iron	69-73	peroxiredoxin 2	Mus musculus	61-65
28793778-13	2018	Prx2 is a key cytoprotector against IO that is induced either by iron supplementation or due to chronic hemolysis as in beta-thalassemia.	Iron	65-69	peroxiredoxin 2	Mus musculus	0-4
30112105-3	2018	The enhanced chemokines transcription is due to the NGAL-mediated intracellular iron uptake.	Iron	80-84	lipocalin 2	Mus musculus	52-56
30692166-6	2019	At the cellular level, the major process redundantly regulated by EPS15 and EPS15L1 is the endocytosis of the transferrin receptor, a pathway that sustains the development of red blood cells and controls iron homeostasis.	Iron	204-208	epidermal growth factor receptor pathway substrate 15-like 1	Mus musculus	76-83
30112105-5	2018	Our results indicate that the NGAL promotes leukocytes recruitment in tumor microenvironment through iron-mediated chemokines production.	Iron	84-88	lipocalin 2	Mus musculus	30-34
29556823-7	2018	In addition, a chromosomally encoded sRNA Atr35C is induced by the vir gene regulator VirG and its expression is affected by iron, manganese, and hydrogen peroxide, suggesting a possible role in oxidative stress responses and Agrobacterium-plant interactions.	Iron	125-129	two-component response regulator VirG	Agrobacterium tumefaciens	86-90
30692166-6	2019	At the cellular level, the major process redundantly regulated by EPS15 and EPS15L1 is the endocytosis of the transferrin receptor, a pathway that sustains the development of red blood cells and controls iron homeostasis.	Iron	204-208	transferrin receptor	Mus musculus	110-130
30692166-7	2019	Consequently, hematopoietic-specific conditional Eps15/Eps15L1-double KO mice display traits of microcytic hypochromic anemia, due to a cell-autonomous defect in iron internalization.	Iron	162-166	epidermal growth factor receptor pathway substrate 15	Mus musculus	49-54
30692166-7	2019	Consequently, hematopoietic-specific conditional Eps15/Eps15L1-double KO mice display traits of microcytic hypochromic anemia, due to a cell-autonomous defect in iron internalization.	Iron	162-166	epidermal growth factor receptor pathway substrate 15-like 1	Mus musculus	55-62
29784877-1	2018	3-Hydroxyanthranilate 3,4-dioxygenase (HAO) is an iron-dependent protein that activates O2 and inserts both oxygen atoms into 3-hydroxyanthranilate (3-HAA).	Iron	50-54	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	0-37
30623799-0	2019	Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress.	Iron	87-91	neuropilin 1	Homo sapiens	0-12
31950640-1	2018	The reaction of [FeII (L. )2 ](BF4 )2 with Li2 TCNQF4 results in the formation of [FeIII (L- )2 ][TCNQF4 .	Iron	17-21	immunoglobulin kappa variable 3-15	Homo sapiens	83-95
31950640-7	2018	Li2 TCNQF4 reduces the [FeII (L. )2 ]2+ dication, which undergoes a reductively induced oxidation to form the [FeIII (L- )2 ]+ monocation resulting in the formation of [FeIII (L- )2 ][TCNQF4 .	Iron	24-28	immunoglobulin kappa variable 3-15	Homo sapiens	111-123
29272493-10	2017	FE was able to detect and quantify ETAR expression targeting the ETAR-specific photoprobe.	Iron	0-2	endothelin receptor type A	Mus musculus	35-39
29272493-10	2017	FE was able to detect and quantify ETAR expression targeting the ETAR-specific photoprobe.	Iron	0-2	endothelin receptor type A	Mus musculus	65-69
29272493-16	2017	Conclusions: We introduced ETAR guided FE in mice for successful in vivo detection and characterization of colorectal neoplasia on a molecular level.	Iron	39-41	endothelin receptor type A	Mus musculus	27-31
31950640-7	2018	Li2 TCNQF4 reduces the [FeII (L. )2 ]2+ dication, which undergoes a reductively induced oxidation to form the [FeIII (L- )2 ]+ monocation resulting in the formation of [FeIII (L- )2 ][TCNQF4 .	Iron	24-28	immunoglobulin kappa variable 3-15	Homo sapiens	169-181
30623799-3	2019	Here, we report that NRP1 promotes mitochondrial function in ECs by preventing iron accumulation and iron-induced oxidative stress through a VEGF-independent mechanism in non-angiogenic ECs.	Iron	79-83	neuropilin 1	Homo sapiens	21-25
30623799-3	2019	Here, we report that NRP1 promotes mitochondrial function in ECs by preventing iron accumulation and iron-induced oxidative stress through a VEGF-independent mechanism in non-angiogenic ECs.	Iron	101-105	neuropilin 1	Homo sapiens	21-25
29208966-2	2017	In this study, we present a high-quality Fe-doped SnS2 monolayer exfoliated using a micromechanical cleavage method.	Iron	41-43	sodium voltage-gated channel alpha subunit 11	Homo sapiens	50-54
30623799-6	2019	NRP1 loss reduces ABCB8 levels, resulting in iron accumulation, iron-induced mitochondrial superoxide production, and iron-dependent EC senescence.	Iron	45-49	neuropilin 1	Homo sapiens	0-4
29208966-5	2017	Magnetic measurements show that pure SnS2 is diamagnetic, whereas Fe0.021Sn0.979S2 exhibits ferromagnetic behavior with a perpendicular anisotropy at 2 K and a Curie temperature of ~31 K. Density functional theory calculations show that long-range ferromagnetic ordering in the Fe-doped SnS2 monolayer is energetically stable, and the estimated Curie temperature agrees well with the results of our experiment.	Iron	66-68	sodium voltage-gated channel alpha subunit 11	Homo sapiens	287-291
29624714-3	2018	A colloidal iron special stain confirmed the deposition of mucin; however, a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative.	Iron	12-16	LOC100508689	Homo sapiens	59-64
30623799-6	2019	NRP1 loss reduces ABCB8 levels, resulting in iron accumulation, iron-induced mitochondrial superoxide production, and iron-dependent EC senescence.	Iron	64-68	neuropilin 1	Homo sapiens	0-4
29208966-6	2017	The results suggest that Fe-doped SnS2 has significant potential in future nanoelectronic, magnetic, and optoelectronic applications.	Iron	25-27	sodium voltage-gated channel alpha subunit 11	Homo sapiens	34-38
30623799-6	2019	NRP1 loss reduces ABCB8 levels, resulting in iron accumulation, iron-induced mitochondrial superoxide production, and iron-dependent EC senescence.	Iron	64-68	neuropilin 1	Homo sapiens	0-4
30650364-0	2019	Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster.	Iron	27-31	Transferrin 1	Drosophila melanogaster	0-13
29070546-4	2017	Key players in mammalian iron trafficking include several types of cells important to iron acquisition, homeostasis, and hematopoiesis (enterocytes, hepatocytes, macrophages, hematopoietic cells, and in the case of pregnancy, placental syncytiotrophoblast cells) and several forms of chaperone proteins, including, for nonheme iron, the transport protein transferrin and the intracellular iron-storage protein ferritin, and for heme iron, the chaperone proteins haptoglobin and hemopexin.	Iron	25-29	hemopexin	Homo sapiens	478-487
28782591-4	2018	Deficient expression of the mitochondrial protein, frataxin, is the primary cause of FA, which leads to adverse alterations in whole cell and mitochondrial iron metabolism.	Iron	156-160	frataxin	Homo sapiens	51-59
30650364-3	2019	To improve our understanding of the conservation of iron metabolism between species, we investigate here the function of the TF homolog in Drosophila melanogaster, transferrin 1 (Tsf1).	Iron	52-56	Transferrin 1	Drosophila melanogaster	164-177
30033414-1	2018	Glutaredoxin-5 (Grx5) is a mitochondrial monothiol, participating in iron-sulfur clusters" biogenesis.	Iron	69-73	glutaredoxin 5	Rattus norvegicus	0-14
30033414-1	2018	Glutaredoxin-5 (Grx5) is a mitochondrial monothiol, participating in iron-sulfur clusters" biogenesis.	Iron	69-73	glutaredoxin 5	Rattus norvegicus	16-20
30033414-8	2018	Rat liver also expressed Grx5, indicating Grx5"s possible involvement in hepatic iron metabolism not only in housekeeping but in pathophysiological conditions as well.	Iron	81-85	glutaredoxin 5	Rattus norvegicus	25-29
30033414-8	2018	Rat liver also expressed Grx5, indicating Grx5"s possible involvement in hepatic iron metabolism not only in housekeeping but in pathophysiological conditions as well.	Iron	81-85	glutaredoxin 5	Rattus norvegicus	42-46
27484685-9	2017	CONCLUSIONS: Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.	Iron	23-27	nicotinamide phosphoribosyltransferase	Homo sapiens	107-115
30650364-3	2019	To improve our understanding of the conservation of iron metabolism between species, we investigate here the function of the TF homolog in Drosophila melanogaster, transferrin 1 (Tsf1).	Iron	52-56	Transferrin 1	Drosophila melanogaster	179-183
30650364-4	2019	Tsf1 knockdown results in iron accumulation in the gut and iron deficiency in the fat body (which is analogous to the mammalian liver).	Iron	26-30	Transferrin 1	Drosophila melanogaster	0-4
30650364-5	2019	Fat body-derived Tsf1 localizes to the gut surface, suggesting that Tsf1 functions in trafficking iron between the gut and the fat body, similar to TF in mammals.	Iron	98-102	Transferrin 1	Drosophila melanogaster	17-21
28838288-0	2017	Overexpression of Drosophila frataxin triggers cell death in an iron-dependent manner.	Iron	64-68	frataxin	Drosophila melanogaster	29-37
28838288-3	2017	FRDA is caused by a loss of function of the mitochondrial protein frataxin which impairs the biosynthesis of iron-sulfur clusters and in turn the catalytic activity of several enzymes in the Krebs cycle and the respiratory chain leading to a diminished energy production.	Iron	109-113	frataxin	Drosophila melanogaster	66-74
29794127-1	2018	The neurodegenerative disease Friedreich"s ataxia is caused by lower than normal levels of frataxin, an important protein involved in iron-sulfur (Fe-S) cluster biogenesis.	Iron	147-151	frataxin	Homo sapiens	91-99
28838288-6	2017	Using molecular, biochemical, histological and behavioral methods, we report that frataxin overexpression is sufficient to increase oxidative phosphorylation, modify mitochondrial morphology, alter iron homeostasis and trigger oxidative stress-dependent cell death.	Iron	198-202	frataxin	Drosophila melanogaster	82-90
30650364-5	2019	Fat body-derived Tsf1 localizes to the gut surface, suggesting that Tsf1 functions in trafficking iron between the gut and the fat body, similar to TF in mammals.	Iron	98-102	Transferrin 1	Drosophila melanogaster	68-72
30650364-6	2019	Moreover, Tsf1 knockdown strongly suppresses the phenotypic effects of ferritin (Fer1HCH) RNAi, an established iron trafficker in Drosophila.	Iron	111-115	Transferrin 1	Drosophila melanogaster	10-14
30650364-6	2019	Moreover, Tsf1 knockdown strongly suppresses the phenotypic effects of ferritin (Fer1HCH) RNAi, an established iron trafficker in Drosophila.	Iron	111-115	Ferritin 1 heavy chain homologue	Drosophila melanogaster	71-79
30182051-2	2018	Hephaestin (HEPH), the only MCF known to be expressed in enterocytes, aids in the basolateral transfer of dietary iron to the blood.	Iron	114-118	hephaestin	Mus musculus	0-10
30650364-6	2019	Moreover, Tsf1 knockdown strongly suppresses the phenotypic effects of ferritin (Fer1HCH) RNAi, an established iron trafficker in Drosophila.	Iron	111-115	Ferritin 1 heavy chain homologue	Drosophila melanogaster	81-88
29195602-0	2017	Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial.	Iron	18-22	homeostatic iron regulator	Homo sapiens	26-29
30650364-7	2019	We propose that Tsf1 and ferritin compete for iron in the Drosophila intestine and demonstrate the value of using Drosophila for investigating iron trafficking and the evolution of systemic iron regulation.	Iron	46-50	Transferrin 1	Drosophila melanogaster	16-20
30650364-7	2019	We propose that Tsf1 and ferritin compete for iron in the Drosophila intestine and demonstrate the value of using Drosophila for investigating iron trafficking and the evolution of systemic iron regulation.	Iron	46-50	Ferritin 1 heavy chain homologue	Drosophila melanogaster	25-33
30650364-7	2019	We propose that Tsf1 and ferritin compete for iron in the Drosophila intestine and demonstrate the value of using Drosophila for investigating iron trafficking and the evolution of systemic iron regulation.	Iron	143-147	Transferrin 1	Drosophila melanogaster	16-20
29937728-0	2018	Lower Expression of Ndfip1 Is Associated With Alzheimer Disease Pathogenesis Through Decreasing DMT1 Degradation and Increasing Iron Influx.	Iron	128-132	Nedd4 family interacting protein 1	Mus musculus	20-26
30650364-7	2019	We propose that Tsf1 and ferritin compete for iron in the Drosophila intestine and demonstrate the value of using Drosophila for investigating iron trafficking and the evolution of systemic iron regulation.	Iron	143-147	Transferrin 1	Drosophila melanogaster	16-20
29937728-2	2018	Recent studies have shown that Nedd4 family interacting protein 1 (Ndfip1) can degrade DMT1 through ubiquitination pathway and reduce the accumulation of intracellular iron.	Iron	168-172	Nedd4 family interacting protein 1	Mus musculus	31-65
29937728-2	2018	Recent studies have shown that Nedd4 family interacting protein 1 (Ndfip1) can degrade DMT1 through ubiquitination pathway and reduce the accumulation of intracellular iron.	Iron	168-172	Nedd4 family interacting protein 1	Mus musculus	67-73
29156454-6	2017	p450 enzymes exhibit C-H oxidation site-selectivity, in which the enzyme scaffold causes a specific C-H bond to be functionalized by placing it close to the iron-oxo haem complex.	Iron	157-161	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4
29937728-2	2018	Recent studies have shown that Nedd4 family interacting protein 1 (Ndfip1) can degrade DMT1 through ubiquitination pathway and reduce the accumulation of intracellular iron.	Iron	168-172	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	87-91
30761254-5	2019	Although an antitransferrin receptor 1 (TfR1) monoclonal antibody inhibited both enucleation and hemoglobin synthesis promoted by holo-Tf, it inhibited only enucleation, but not hemoglobin synthesis, promoted by hinokitiol plus iron.	Iron	228-232	transferrin receptor	Mus musculus	40-44
29937728-3	2018	The present study aims to evaluate whether Ndfip1 is involved in AD pathogenesis through mediating DMT1 degradation and iron metabolism.	Iron	120-124	Nedd4 family interacting protein 1	Mus musculus	43-49
29937728-11	2018	Further, overexpressed Ndfip1 significantly attenuated iron-induced cell damage in Ndfip1 transfected cells.	Iron	55-59	Nedd4 family interacting protein 1	Mus musculus	23-29
29937728-11	2018	Further, overexpressed Ndfip1 significantly attenuated iron-induced cell damage in Ndfip1 transfected cells.	Iron	55-59	Nedd4 family interacting protein 1	Mus musculus	83-89
29937728-12	2018	The present study suggests that lower expression of Ndfip1 might be associated with the pathogenesis of AD, through decreasing DMT1 degradation and increasing iron accumulation in the brain.	Iron	159-163	Nedd4 family interacting protein 1	Mus musculus	52-58
29749225-2	2018	Currently, the best non-noble metal OER electrocatalyst in base conditions is the Fe-doped NiOOH (Ni1- xFe xOOH), with an overpotential of eta = 0.4, but much lower values are desired.	Iron	82-84	endothelin receptor type A	Homo sapiens	31-34
29380557-3	2018	We hypothesize that an impaired Akt-FOXO3a signalling pathway triggers changes in the iron metabolism in the muscles of transgenic animals.	Iron	86-90	forkhead box O3	Rattus norvegicus	36-42
29896207-6	2018	Quantitative real time-PCR showed that the transcription levels of CrFAP89 were significantly enhanced upon nutrient deprivation, including nitrogen, sulfur, or iron starvation, which is considered an effective condition to promote triacylglycerol (TAG) accumulation in microalgae.	Iron	161-165	uncharacterized protein	Chlamydomonas reinhardtii	67-74
29771935-4	2018	Iron-enriched diet increased M2 marker Arg1 and Ym1 expression in liver and peritoneal macrophages, while iron deficiency decreased Arg1 expression.	Iron	0-4	arginase 1	Homo sapiens	39-43
29771935-4	2018	Iron-enriched diet increased M2 marker Arg1 and Ym1 expression in liver and peritoneal macrophages, while iron deficiency decreased Arg1 expression.	Iron	0-4	arginase 1	Homo sapiens	132-136
28874056-9	2018	INNOVATION: CP alterations in iron contents were mediated through DMT1(-IRE) and changes in ROS levels, which in turn attenuated the progression of AD through the Erk/p38 and Bcl-2/Bax signaling pathways.	Iron	30-34	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	66-70
29725013-0	2018	Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.	Iron	0-4	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	145-149
29725013-11	2018	In addition, iron chelation or antioxidant weakened the activity of the AMPK/MFF/Drp1 pathway in MDS-MSCs with IO from several patients, accompanied by attenuation of mitochondrial fragmentation and autophagy.	Iron	13-17	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	72-76
28941588-1	2018	The cysteine desulfurase Nfs1/Isd11 uses the amino acid cysteine as the substrate and its activity is absolutely required for contributing persulfide sulfur to the essential process of iron-sulfur (Fe-S) cluster assembly in mitochondria.	Iron	198-202	Isd11p	Saccharomyces cerevisiae S288C	30-35
29700330-0	2018	Prion protein modulates glucose homeostasis by altering intracellular iron.	Iron	70-74	prion protein	Mus musculus	0-13
29700330-3	2018	We report expression of PrPC on mouse pancreatic beta-cells, where it promoted uptake of iron through divalent-metal-transporters.	Iron	89-93	prion protein	Mus musculus	24-28
29700330-4	2018	Accordingly, pancreatic iron stores in PrP knockout mice (PrP-/-) were significantly lower than wild type (PrP+/+) controls.	Iron	24-28	prion protein	Mus musculus	39-42
29700330-4	2018	Accordingly, pancreatic iron stores in PrP knockout mice (PrP-/-) were significantly lower than wild type (PrP+/+) controls.	Iron	24-28	prion protein	Mus musculus	58-61
29700330-4	2018	Accordingly, pancreatic iron stores in PrP knockout mice (PrP-/-) were significantly lower than wild type (PrP+/+) controls.	Iron	24-28	prion protein	Mus musculus	58-61
29700330-7	2018	Similar observations were noted in the brain, liver, and neuroretina of iron overloaded PrP+/+ but not PrP-/- mice, indicating PrPC-mediated modulation of insulin and glucose homeostasis through iron.	Iron	72-76	prion protein	Mus musculus	88-91
29700330-7	2018	Similar observations were noted in the brain, liver, and neuroretina of iron overloaded PrP+/+ but not PrP-/- mice, indicating PrPC-mediated modulation of insulin and glucose homeostasis through iron.	Iron	72-76	prion protein	Mus musculus	127-131
29700330-7	2018	Similar observations were noted in the brain, liver, and neuroretina of iron overloaded PrP+/+ but not PrP-/- mice, indicating PrPC-mediated modulation of insulin and glucose homeostasis through iron.	Iron	195-199	prion protein	Mus musculus	127-131
29652073-1	2018	In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor.	Iron	79-83	aconitase 1	Homo sapiens	165-169
29652073-1	2018	In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor.	Iron	139-143	aconitase 1	Homo sapiens	165-169
29652073-1	2018	In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor.	Iron	188-192	aconitase 1	Homo sapiens	165-169
29077236-4	2018	The ketone moiety does not bind to the metal in MII complexes, whereas MI complexes (Fe, Co, Ni) adopt an eta2 (C,O) coordination.	Iron	85-87	DNA polymerase iota	Homo sapiens	106-110
29620054-6	2018	Cellular iron excess in HFE and non-HFE forms of haemochromatosis is caused by increased concentrations of plasma iron, which can lead to the accumulation of iron in parenchymal cells, particularly hepatocytes, pancreatic cells and cardiomyocytes.	Iron	9-13	homeostatic iron regulator	Homo sapiens	24-27
29620054-6	2018	Cellular iron excess in HFE and non-HFE forms of haemochromatosis is caused by increased concentrations of plasma iron, which can lead to the accumulation of iron in parenchymal cells, particularly hepatocytes, pancreatic cells and cardiomyocytes.	Iron	114-118	homeostatic iron regulator	Homo sapiens	24-27
29620054-6	2018	Cellular iron excess in HFE and non-HFE forms of haemochromatosis is caused by increased concentrations of plasma iron, which can lead to the accumulation of iron in parenchymal cells, particularly hepatocytes, pancreatic cells and cardiomyocytes.	Iron	114-118	homeostatic iron regulator	Homo sapiens	36-39
29620054-6	2018	Cellular iron excess in HFE and non-HFE forms of haemochromatosis is caused by increased concentrations of plasma iron, which can lead to the accumulation of iron in parenchymal cells, particularly hepatocytes, pancreatic cells and cardiomyocytes.	Iron	114-118	homeostatic iron regulator	Homo sapiens	24-27
29620054-6	2018	Cellular iron excess in HFE and non-HFE forms of haemochromatosis is caused by increased concentrations of plasma iron, which can lead to the accumulation of iron in parenchymal cells, particularly hepatocytes, pancreatic cells and cardiomyocytes.	Iron	114-118	homeostatic iron regulator	Homo sapiens	36-39
29090418-2	2018	Although the frataxin function is not yet entirely clear, it has been associated to the machine that builds iron-sulfur clusters, essential prosthetic groups involved in several processes and is strongly conserved in organisms from bacteria to humans.	Iron	108-112	frataxin	Homo sapiens	13-21
29659961-8	2018	Results: Iron concentration was significantly higher in Heph/Cp KO mice than in WT control mice at 4 wk of age in the cortex (50%), hippocampus (120%), brainstem (35%), and cerebellum (220%) and at 6 mo of age in the cortex (140%), hippocampus (420%), brainstem (560%), and cerebellum (340%).	Iron	9-13	hephaestin	Mus musculus	56-60
29527811-5	2018	In addition, the Fe2 O3 @Ni3 Se4 nanotubes with INi:Fe = 1:10 (the atomic ratio between Ni and Fe) show superior electrocatalytic performance toward the oxygen evolution reaction with an overpotential of only 246 mV at 10 mA cm-2 and a low Tafel slope of 51 mV dec-1 in 1 m KOH solution.	Iron	17-19	deleted in esophageal cancer 1	Homo sapiens	261-266
29527811-5	2018	In addition, the Fe2 O3 @Ni3 Se4 nanotubes with INi:Fe = 1:10 (the atomic ratio between Ni and Fe) show superior electrocatalytic performance toward the oxygen evolution reaction with an overpotential of only 246 mV at 10 mA cm-2 and a low Tafel slope of 51 mV dec-1 in 1 m KOH solution.	Iron	52-54	deleted in esophageal cancer 1	Homo sapiens	261-266
29609266-5	2018	Conclusion: The 3D FE model of WSCS could provide more insights on the biomechanical mechanisms of spinal cord injury through various bone fragment impacts in burst fracture.When the impact velocity of the bone fragment exceeds 3.5 m/s, the maximum stress significantly increases and the reduction of CSA of the spinal cord is over 30%, and this could possibly lead to the contusion injury of the spinal cord.	Iron	19-21	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	301-304
29406711-6	2018	In overall Fe-S cluster assembly, frataxin was found to stimulate cluster assembly with both the wild-type and structured variants when the reductant was DTT; however, with the physiological reductant, reduced ferredoxin 2 (rdFDX2), FXN stimulated the reaction with wild-type ISCU but not with either ISCU(M108I) or ISCU(D39V).	Iron	11-15	frataxin	Homo sapiens	34-42
29032941-0	2018	Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.	Iron	9-13	nuclear receptor coactivator 4	Mus musculus	36-41
29032941-0	2018	Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.	Iron	63-67	nuclear receptor coactivator 4	Mus musculus	36-41
29032941-2	2018	We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release.	Iron	126-130	nuclear receptor coactivator 4	Mus musculus	94-99
29032941-2	2018	We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release.	Iron	126-130	nuclear receptor coactivator 4	Mus musculus	242-247
29032941-2	2018	We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release.	Iron	194-198	nuclear receptor coactivator 4	Mus musculus	94-99
29032941-2	2018	We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release.	Iron	194-198	nuclear receptor coactivator 4	Mus musculus	94-99
29032941-2	2018	We recently described the roles of poly rC-binding protein (PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and iron release.	Iron	194-198	nuclear receptor coactivator 4	Mus musculus	94-99
29353079-1	2018	Transferrin (TF), an iron-binding glycoprotein, plays an important role in host defense against pathogenic infection, which inhibits the growth and proliferation of pathogens, deprives iron from invading pathogens, and activates anti-microbial responses in macrophages.	Iron	21-25	serotransferrin-like	Oreochromis niloticus	0-11
29353079-1	2018	Transferrin (TF), an iron-binding glycoprotein, plays an important role in host defense against pathogenic infection, which inhibits the growth and proliferation of pathogens, deprives iron from invading pathogens, and activates anti-microbial responses in macrophages.	Iron	21-25	serotransferrin-like	Oreochromis niloticus	13-15
29329026-3	2018	The associated redox potentials of the iron complexes were determined using cyclic voltammetry at pH7.4 as +130mV (vs normal hydrogen electrode, NHE) for PIH and +136mV(vs NHE) for SIH.	Iron	39-43	solute carrier family 9 member C1	Homo sapiens	145-148
29329026-3	2018	The associated redox potentials of the iron complexes were determined using cyclic voltammetry at pH7.4 as +130mV (vs normal hydrogen electrode, NHE) for PIH and +136mV(vs NHE) for SIH.	Iron	39-43	solute carrier family 9 member C1	Homo sapiens	172-175
29446430-3	2018	It is found that the as-synthesized 80 nm-sized SnO2-Fe2O3-C hollow sphere electrode exhibits an extraordinary reversible capacity (1100 mA h g-1 after 100 cycles at 200 mA g-1) and excellent long cycle stability (475 mA h g-1 after 1000 cycles at 2000 mA g-1), which are attributed to the Fe-enhanced reversibility of the Li2O reduction reaction, high electrical conductivity, high Li+ ion mobility, and structural stability of the carbon-coated triple-shell hollow spheres.	Iron	53-55	ATP binding cassette subfamily A member 12	Homo sapiens	323-326
29491838-8	2018	A biochemically active Fe-S core complex of heterologously expressed fly Nfs1, Isd11, IscU, and human frataxin is presented.	Iron	23-27	frataxin	Homo sapiens	102-110
29330752-5	2018	Identifying authentic IRP interactions is not only important to a greater understanding of iron homeostasis and its integration with cell biology but also to the development of novel therapeutics that can compensate for iron imbalances.	Iron	91-95	Wnt family member 2	Homo sapiens	22-25
29168506-3	2017	Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1.	Iron	116-120	NFS1 cysteine desulfurase	Homo sapiens	156-160
29138470-6	2017	These findings suggest that circulating LCN2 possesses obesity-promoting and anti-thermogenic effects through inhibition of BAT activity in an iron-dependent manner.	Iron	143-147	lipocalin 2	Mus musculus	40-44
29404515-0	2018	Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease.	Iron	100-104	secreted phosphoprotein 1	Mus musculus	0-11
29404515-11	2018	Conclusion: Opn deletion promotes HPSC mobilization, PMN infiltration, and iron deposits in the liver and thereby enhances the severity of ALD.	Iron	75-79	secreted phosphoprotein 1	Mus musculus	12-15
28991466-2	2017	Chiral frameworks of the type M2(dobpdc) (M = Mg, Mn, Fe, Co, Ni, Zn; dobpdc4- = 4,4"-dioxidobiphenyl-3,3"-dicarboxylate) seem particularly promising for potential applications because of their excellent stability, high internal surface areas, and strongly polarizing open metal coordination sites within the channels, but to date these materials have been isolated only in racemic form.	Iron	54-56	mucin 7, secreted	Homo sapiens	33-39
28669019-12	2017	These results suggest that impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD.	Iron	123-127	cytochrome b reductase 1	Rattus norvegicus	61-67
28782610-5	2017	Anti-CTGF-USPIO-treated macrophages showed the greatest iron uptake.	Iron	56-60	cellular communication network factor 2	Mus musculus	5-9
28780484-1	2017	Hepcidin (HEP) and ferroportin (FPN) play a central role in systemic iron homeostasis.	Iron	69-73	hepcidin antimicrobial peptide	Bos taurus	0-8
28780484-1	2017	Hepcidin (HEP) and ferroportin (FPN) play a central role in systemic iron homeostasis.	Iron	69-73	hepcidin antimicrobial peptide	Bos taurus	10-13
28780484-2	2017	The HEP/FPN axis controls both extracellular iron concentration and total body iron levels.	Iron	45-49	hepcidin antimicrobial peptide	Bos taurus	4-7
28780484-2	2017	The HEP/FPN axis controls both extracellular iron concentration and total body iron levels.	Iron	79-83	hepcidin antimicrobial peptide	Bos taurus	4-7
28780484-3	2017	HEP is synthesized mainly by hepatocytes and controls the absorption of dietary iron and the distribution of iron to the various cell types; its synthesis is regulated by both iron and innate immunity.	Iron	80-84	hepcidin antimicrobial peptide	Bos taurus	0-3
28780484-3	2017	HEP is synthesized mainly by hepatocytes and controls the absorption of dietary iron and the distribution of iron to the various cell types; its synthesis is regulated by both iron and innate immunity.	Iron	109-113	hepcidin antimicrobial peptide	Bos taurus	0-3
28780484-3	2017	HEP is synthesized mainly by hepatocytes and controls the absorption of dietary iron and the distribution of iron to the various cell types; its synthesis is regulated by both iron and innate immunity.	Iron	109-113	hepcidin antimicrobial peptide	Bos taurus	0-3
28780484-5	2017	HEP limits the pool of extracellular iron by binding FPN and mediating its degradation, thus preventing its release from intracellular sources.	Iron	37-41	hepcidin antimicrobial peptide	Bos taurus	0-3
28780484-15	2017	In addition, HEP may be responsible for iron flux regulation as a molecular bridge for iron trafficking and response to infection.	Iron	40-44	hepcidin antimicrobial peptide	Bos taurus	13-16
28780484-15	2017	In addition, HEP may be responsible for iron flux regulation as a molecular bridge for iron trafficking and response to infection.	Iron	87-91	hepcidin antimicrobial peptide	Bos taurus	13-16
28671201-0	2017	The transferrin receptor: the cellular iron gate.	Iron	39-43	transferrin receptor	Homo sapiens	4-24
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	57-61	transferrin receptor	Homo sapiens	4-24
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	57-61	transferrin receptor	Homo sapiens	26-30
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	111-115	transferrin receptor	Homo sapiens	4-24
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	111-115	transferrin receptor	Homo sapiens	26-30
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	111-115	transferrin receptor	Homo sapiens	4-24
28671201-1	2017	The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis.	Iron	111-115	transferrin receptor	Homo sapiens	26-30
28671201-2	2017	Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels.	Iron	85-89	transferrin receptor	Homo sapiens	20-24
28671201-2	2017	Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels.	Iron	135-139	transferrin receptor	Homo sapiens	20-24
28671201-3	2017	In this review, we have discussed the latest advances in the molecular regulation of TfR1 expression and we have considered current understanding of TfR1 function beyond its canonical role in providing iron for erythroid precursors and rapidly proliferating cells.	Iron	202-206	transferrin receptor	Homo sapiens	149-153
28864672-2	2017	However, for the recently discovered coproporphyrin-dependent pathway, ferrochelatase catalyses the penultimate reaction where ferrous iron is inserted into coproporphyrin III.	Iron	135-139	AT695_RS08245	Staphylococcus aureus	71-85
28864672-3	2017	Ferrochelatase enzymes from the bacterial phyla Firmicutes and Actinobacteria have previously been shown to insert iron into coproporphyrin, and those from Bacillus subtilis and Staphylococcus aureus are known to be inhibited by elevated iron concentrations.	Iron	115-119	AT695_RS08245	Staphylococcus aureus	0-14
28864672-3	2017	Ferrochelatase enzymes from the bacterial phyla Firmicutes and Actinobacteria have previously been shown to insert iron into coproporphyrin, and those from Bacillus subtilis and Staphylococcus aureus are known to be inhibited by elevated iron concentrations.	Iron	238-242	AT695_RS08245	Staphylococcus aureus	0-14
28864672-4	2017	The work herein reports a Km (coproporphyrin III) for S. aureus ferrochelatase of 1.5 microM and it is shown that elevating the iron concentration increases the Km for coproporphyrin III, providing a potential explanation for the observed iron-mediated substrate inhibition.	Iron	128-132	AT695_RS08245	Staphylococcus aureus	64-78
28864672-4	2017	The work herein reports a Km (coproporphyrin III) for S. aureus ferrochelatase of 1.5 microM and it is shown that elevating the iron concentration increases the Km for coproporphyrin III, providing a potential explanation for the observed iron-mediated substrate inhibition.	Iron	239-243	AT695_RS08245	Staphylococcus aureus	64-78
28864672-5	2017	Together, structural modelling, site-directed mutagenesis, and kinetic analyses confirm residue Glu271 as being essential for the binding of iron to the inhibitory regulatory site on S. aureus ferrochelatase, providing a molecular explanation for the observed substrate inhibition patterns.	Iron	141-145	AT695_RS08245	Staphylococcus aureus	193-207
28885024-5	2017	Fe atoms, 4,4""-dicyano-1,1":3",1""-terphenyl, and 1,3-bis(4-pyridyl)benzene molecules were used to build fractals on the reconstructed Au(100)-(hex) surface.	Iron	0-2	hematopoietically expressed homeobox	Homo sapiens	145-148
28809076-4	2017	For example, 2 at % Fe (atomic percent) doped Ni3 C nanosheets depict a low overpotential (292 mV) and a small Tafel slope (41.3 mV dec-1 ) for HER in KOH solution.	Iron	20-22	deleted in esophageal cancer 1	Homo sapiens	132-137
28802701-6	2017	We show that in addition to the complex I bound fraction, ACPM1 is present as a free matrix protein and in complex with the soluble LYRM4(ISD11)/NFS1 complex implicated in Fe-S cluster biogenesis.	Iron	172-174	Isd11p	Saccharomyces cerevisiae S288C	138-143
28111337-4	2017	METHODS: We performed a longitudinal cohort study of 266 individuals homozygous for the C282Y substitution in HFE, seen at a tertiary reference center in Rennes, France, and followed for 3 or more years after initial iron removal.	Iron	217-221	homeostatic iron regulator	Homo sapiens	110-113
28727322-1	2017	The HFE molecule controls iron uptake from gut, and defects in the molecule have been associated with iron overload, particularly in hereditary hemochromatosis.	Iron	26-30	homeostatic iron regulator	Homo sapiens	4-7
28727322-1	2017	The HFE molecule controls iron uptake from gut, and defects in the molecule have been associated with iron overload, particularly in hereditary hemochromatosis.	Iron	102-106	homeostatic iron regulator	Homo sapiens	4-7
28794014-0	2017	Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling.	Iron	0-4	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	13-17
28939752-1	2017	The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5.	Iron	16-20	aconitase 1	Homo sapiens	41-45
28939752-1	2017	The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5.	Iron	81-83	aconitase 1	Homo sapiens	41-45
28914813-2	2017	HLf and bovine Lf (bLf), possessing high sequence homology and identical functions, inhibit bacterial growth and biofilm dependently from iron binding ability while, independently, bacterial adhesion to and the entry into cells.	Iron	138-142	HLF transcription factor, PAR bZIP family member	Bos taurus	0-3
29404495-4	2017	We then evaluated the correlation of nicotinamide N-methyltransferase (NNMT) expression with body iron stores in human patients and the effect of NNMT knockdown on gene expression and viability in primary mouse hepatocytes.	Iron	98-102	nicotinamide N-methyltransferase	Homo sapiens	71-75
29404495-6	2017	We found that hepatic NNMT expression is inversely correlated with serum ferritin levels and serum transferrin saturation in patients who are obese, suggesting that body iron stores regulate human liver NNMT expression.	Iron	170-174	nicotinamide N-methyltransferase	Homo sapiens	22-26
29404495-6	2017	We found that hepatic NNMT expression is inversely correlated with serum ferritin levels and serum transferrin saturation in patients who are obese, suggesting that body iron stores regulate human liver NNMT expression.	Iron	170-174	nicotinamide N-methyltransferase	Homo sapiens	203-207
28669928-4	2017	Furthermore, angiocrine Bmp2 signaling in the liver in vivo was demonstrated to control iron homeostasis.	Iron	88-92	bone morphogenetic protein 2	Homo sapiens	24-28
28700905-9	2017	Moreover, increased ACE activity was observed in the mesenteric resistance arteries of iron-overloaded rats accompanied by an increase in gp91phox, catalase, ERK1/2 and eNOS protein expression.	Iron	87-91	mitogen activated protein kinase 3	Rattus norvegicus	158-164
28396286-6	2017	Measurements of mitochondrial membrane potential, mitochondrial chelatable iron pool, intracellular lipid peroxidation, and peroxisome numbers in primary hepatocytes confirmed that LCN2 regulates mitochondrial and peroxisomal integrity.	Iron	75-79	lipocalin 2	Mus musculus	181-185
28502703-7	2017	IRP1 knockdown cells presented higher ferritin levels, a lower iron labile pool, increased resistance to cysteine oxidation and decreased oxidative modifications.	Iron	63-67	aconitase 1	Homo sapiens	0-4
28502703-8	2017	These results support the concept that IRP1 is an oxidative stress biosensor that mediates iron accumulation and cell death when deregulated by mitochondrial dysfunction.	Iron	91-95	aconitase 1	Homo sapiens	39-43
28502703-9	2017	IRP1 activation, secondary to mitochondrial dysfunction, may underlie the events leading to iron dyshomeostasis and neuronal death observed in neurodegenerative disorders with an iron accumulation component.	Iron	92-96	aconitase 1	Homo sapiens	0-4
28502703-9	2017	IRP1 activation, secondary to mitochondrial dysfunction, may underlie the events leading to iron dyshomeostasis and neuronal death observed in neurodegenerative disorders with an iron accumulation component.	Iron	179-183	aconitase 1	Homo sapiens	0-4
28586532-10	2017	CONCLUSION: Severe periodontitis is associated with the severity of iron burden in patients with HFE-related hereditary haemochromatosis.	Iron	68-72	homeostatic iron regulator	Homo sapiens	97-100
29330752-5	2018	Identifying authentic IRP interactions is not only important to a greater understanding of iron homeostasis and its integration with cell biology but also to the development of novel therapeutics that can compensate for iron imbalances.	Iron	220-224	Wnt family member 2	Homo sapiens	22-25
29237592-0	2018	Hepatic Smad7 overexpression causes severe iron overload in mice.	Iron	43-47	SMAD family member 7	Mus musculus	8-13
29101890-8	2018	The sudden increase in atmospheric PAH concentrations in the winter of 2014 may also be due to iron manufacturing.	Iron	95-99	phenylalanine hydroxylase	Homo sapiens	35-38
29490098-11	2018	Studies with 65Zn, 59Fe [nontransferrin-bound iron (NTBI)] and 54Mn show that ZIP14 transports these metals.	Iron	46-50	solute carrier family 39 (zinc transporter), member 14	Mus musculus	78-83
29386206-5	2018	Choroid plexus epithelial cells also contain iron-responsive element-binding proteins (IRPs), IRP1, and IRP2 that bind to mRNA iron-responsive elements.	Iron	127-131	aconitase 1	Rattus norvegicus	94-98
29271190-1	2018	Transferrin receptor (TfR) is overexpressed on the surface of many cancer cells due to its vital roles in iron circulation and cellular respiration.	Iron	106-110	transferrin receptor	Homo sapiens	0-20
28075024-9	2017	Genes related to heme degradation and iron transport such as hepcidin, transferrin and haptoglobin were primary upregulated in Atlantic salmon; meanwhile, in coho salmon, genes associated with heme biosynthesis were strongly transcribed.	Iron	38-42	hepcidin	Salmo salar	61-69
30881609-3	2019	Recently, yeast Acp1 was found to interact with several mitochondrial complexes, including the iron-sulfur (Fe-S) cluster biosynthesis and respiratory complexes, via the binding to LYRM proteins, a family of proteins involved in assembly/stability of complexes.	Iron	108-112	acyl carrier protein	Saccharomyces cerevisiae S288C	16-20
28851903-4	2017	PrPC is expressed on the basolateral membrane of retinal-pigment-epithelial (RPE) cells, where it mediates uptake of iron by the neuroretina.	Iron	117-121	prion protein	Mus musculus	0-4
28851903-5	2017	Accordingly, the neuroretina of PrP-knock-out mice is iron-deficient.	Iron	54-58	prion protein	Mus musculus	32-35
28851903-6	2017	In RPE19 cells, silencing of PrPC decreases ferritin while over-expression upregulates ferritin and divalent-metal-transporter-1 (DMT-1), indicating PrPC-mediated iron uptake through DMT-1.	Iron	163-167	prion protein	Mus musculus	29-33
28851903-7	2017	Polarization of RPE19 cells results in upregulation of ferritin by ~10-fold and beta-cleavage of PrPC, the latter likely to block further uptake of iron due to cleavage of the ferrireductase domain.	Iron	148-152	prion protein	Mus musculus	97-101
29271190-1	2018	Transferrin receptor (TfR) is overexpressed on the surface of many cancer cells due to its vital roles in iron circulation and cellular respiration.	Iron	106-110	transferrin receptor	Homo sapiens	22-25
28864256-9	2018	Pica during the current pregnancy was significantly associated with higher TfR concentrations [OR: 1.29; 95% CI: 1.11, 1.51] indicative of low iron stores and greater food insecurity [OR: 1.20, 95% CI: 1.03, 1.40].	Iron	143-147	transferrin receptor	Homo sapiens	75-78
30612208-1	2019	The existence and stabilities of various neutral metal oxides of formula MON and MON2 (M = Fe, Co, Ni; N = Li, Na) and their corresponding cations MON+ and MON2+ are predicted using density functional theory (B3LYP) with the 6-311 + G(d) basis set.	Iron	91-93	MON2 homolog, regulator of endosome-to-Golgi trafficking	Homo sapiens	81-85
29158088-6	2018	Hepatic iron content was associated with the increase in mRNA levels of divalent metal transporter 1 and transferrin receptor.	Iron	8-12	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	72-100
28615450-0	2017	Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.	Iron	26-30	radical S-adenosyl methionine domain containing 2	Homo sapiens	95-102
28615450-2	2017	Viperin"s iron-sulfur (Fe/S) cluster is critical for its antiviral activity against many different viruses.	Iron	10-14	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
28615450-2	2017	Viperin"s iron-sulfur (Fe/S) cluster is critical for its antiviral activity against many different viruses.	Iron	23-25	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
29875008-2	2018	Transferrin receptor 1 (CD71) is a trans-membrane glycoprotein which has important role in iron homeostasis by acting as a gatekeeper regulating iron uptake from transferrin and is an attractive target for anti-cancer agents, particularly those that aim to induce lethal iron deprivation in malignant hematopoietic cells.	Iron	91-95	transferrin receptor	Homo sapiens	24-28
29875008-2	2018	Transferrin receptor 1 (CD71) is a trans-membrane glycoprotein which has important role in iron homeostasis by acting as a gatekeeper regulating iron uptake from transferrin and is an attractive target for anti-cancer agents, particularly those that aim to induce lethal iron deprivation in malignant hematopoietic cells.	Iron	145-149	transferrin receptor	Homo sapiens	24-28
29875008-2	2018	Transferrin receptor 1 (CD71) is a trans-membrane glycoprotein which has important role in iron homeostasis by acting as a gatekeeper regulating iron uptake from transferrin and is an attractive target for anti-cancer agents, particularly those that aim to induce lethal iron deprivation in malignant hematopoietic cells.	Iron	145-149	transferrin receptor	Homo sapiens	24-28
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	82-86	high mobility group box 1	Mus musculus	235-240
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	82-86	homeostatic iron regulator	Homo sapiens	99-102
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	142-146	homeostatic iron regulator	Homo sapiens	99-102
28819260-0	2017	Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1.	Iron	38-42	aconitase 1	Homo sapiens	107-111
29666474-3	2019	Other members of the CDGSH iron sulfur domain (CISD) family include mitoNEET/CISD1 and Miner2/CISD3.	Iron	27-31	CDGSH iron sulfur domain 3	Homo sapiens	87-93
28035629-1	2017	INTRODUCTION: Amongst populations of northern European ancestry, HFE-associated haemochromatosis is a common genetic disorder characterised by iron overload.	Iron	143-147	homeostatic iron regulator	Homo sapiens	65-68
28771940-1	2018	BACKGROUND AND PURPOSE: The H63D-HFE single nucleotide polymorphism (SNP) has been associated with brain iron dysregulation; however, the emergent role of this missense variant in brain structure and function has yet to be determined.	Iron	105-109	homeostatic iron regulator	Homo sapiens	33-36
29666474-3	2019	Other members of the CDGSH iron sulfur domain (CISD) family include mitoNEET/CISD1 and Miner2/CISD3.	Iron	27-31	CDGSH iron sulfur domain 3	Homo sapiens	94-99
29746245-0	2018	Characterization of Glutaredoxin Fe-S Cluster-Binding Interactions Using Circular Dichroism Spectroscopy.	Iron	33-37	glutaredoxin	Homo sapiens	20-32
28552631-6	2017	Induction of ferroptosis due to cysteine depletion leads to the degradation of ferritin (i.e. ferritinophagy), which releases iron via the NCOA4-mediated autophagy pathway.	Iron	126-130	nuclear receptor coactivator 4	Mus musculus	139-144
29746245-2	2018	Various analytical and spectroscopic methods are currently being used to monitor and characterize glutaredoxin Fe-S cluster-dependent interactions at the molecular level.	Iron	111-115	glutaredoxin	Homo sapiens	98-110
31405709-11	2019	Higher adhering to hPDI may as a result in higher intake of fiber intake, antioxidants, unsaturated fats, micronutrients, could reduce saturated fats and iron content, and finally weight loss, and reduce inflammation in the body.	Iron	154-158	prolyl 4-hydroxylase subunit beta	Homo sapiens	19-23
29746245-5	2018	In this chapter, we focus on the use of UV-visible circular dichroism spectroscopy as a fast and simple initial approach for investigating glutaredoxin Fe-S cluster-dependent interactions.	Iron	152-156	glutaredoxin	Homo sapiens	139-151
30509471-1	2018	The chapter focuses on the methods involved in producing and characterizing two key nickel-iron-sulfur enzymes in the Wood-Ljungdahl pathway (WLP) of anaerobic conversion of carbon dioxide fixation into acetyl-CoA: carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS).	Iron	91-95	acyl-CoA synthetase short chain family member 2	Homo sapiens	256-275
30509471-1	2018	The chapter focuses on the methods involved in producing and characterizing two key nickel-iron-sulfur enzymes in the Wood-Ljungdahl pathway (WLP) of anaerobic conversion of carbon dioxide fixation into acetyl-CoA: carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS).	Iron	91-95	acyl-CoA synthetase short chain family member 2	Homo sapiens	277-280
28405918-1	2017	Atonal homolog 8 (ATOH8) is defined as a positive regulator of hepcidin transcription, which links erythropoietic activity with iron-sensing molecules.	Iron	128-132	atonal bHLH transcription factor 8	Homo sapiens	0-16
28405918-1	2017	Atonal homolog 8 (ATOH8) is defined as a positive regulator of hepcidin transcription, which links erythropoietic activity with iron-sensing molecules.	Iron	128-132	atonal bHLH transcription factor 8	Homo sapiens	18-23
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	5-9	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	46-51
28431172-1	2017	The spatial distribution of Li ions in a lithium iron phosphate (Li1-xFePO4) single crystal after chemical delithiation is quantitatively investigated using Fe M2,3-edge and valence electron energy loss (EEL) spectroscopy techniques.	Iron	70-72	transglutaminase 1	Homo sapiens	65-68
29292794-6	2017	Moreover, knockdown of p53 resulted in higher non-transferrin-bound iron uptake, which was mediated by increased ZIP14 levels.	Iron	68-72	solute carrier family 39 member 14	Homo sapiens	113-118
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	5-9	Iba57p	Saccharomyces cerevisiae S288C	70-76
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	87-91	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	46-51
29343425-1	2019	The [Fe-S] late-acting subsystem comprised of Isa1p/Isa2p, Grx5p, and Iba57p proteins (Fe-S-IBG subsystem) is involved in [4Fe-4S]-cluster protein assembly.	Iron	87-91	Iba57p	Saccharomyces cerevisiae S288C	70-76
29296776-5	2017	Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase.	Iron	44-48	hephaestin	Mus musculus	170-174
29296776-5	2017	Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase.	Iron	207-211	hephaestin	Mus musculus	170-174
29296776-5	2017	Furthermore, because ferroportin 1-mediated iron export from some tissues (eg, liver) is impaired in the absence of the Heph homolog, ceruloplasmin, we hypothesized that Heph is rate limiting for intestinal iron absorption, especially when iron demands increase.	Iron	207-211	hephaestin	Mus musculus	170-174
29296776-7	2017	Results demonstrate that intestinal Heph is essential for optimal iron transport in weanlings and adults of both sexes and during pregnancy, but not in adult mice with iron-deficiency or hemolytic anemia.	Iron	66-70	hephaestin	Mus musculus	36-40
29296776-8	2017	Moreover, activation of unidentified, intestinal ferroxidases was noted, which may explain why intestinal Heph is not always required for optimal iron absorption.	Iron	146-150	hephaestin	Mus musculus	106-110
29200434-10	2017	We also show that CyaY oligomers may be dissociated by ferric iron chelators deferiprone and DFO, as well as by the ferrous iron chelator BIPY.	Iron	62-66	frataxin	Homo sapiens	18-22
28818478-0	2017	Mutations in DDHD1, encoding a phospholipase A1, is a novel cause of retinopathy and neurodegeneration with brain iron accumulation.	Iron	114-118	lipase H	Homo sapiens	31-47
30798813-4	2019	Genetic polymorphisms of the HFE gene (rs1800562, rs1799945 and rs1800730) also affect the normal activity of another protein, hepcidin, a negative regulator of iron homeostasis.	Iron	161-165	homeostatic iron regulator	Homo sapiens	29-32
28888005-12	2017	Electrochemical measurements and immersion tests indicated that the addition of Mg2Si could increase the corrosion rate of Fe even twice (from 0.14 to 0.28mm year-1).	Iron	123-125	mucin 7, secreted	Homo sapiens	80-83
28412459-2	2017	Frataxin is thought to play a role in iron-sulfur cluster biogenesis and heme synthesis.	Iron	38-42	frataxin	Homo sapiens	0-8
30798813-9	2019	In order to prevent the progression of iron accumulation, an early detection may be achieved by genotypic check of the frequent mutations of the HFE.	Iron	39-43	homeostatic iron regulator	Homo sapiens	145-148
29168506-6	2017	NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage.	Iron	60-64	NFS1 cysteine desulfurase	Homo sapiens	0-4
30212672-2	2018	The operational parameters of photoelectro-peroxone/zero valent iron (PEP/ZVI) process were studied and the complete decoloration was found at pH = 3.0, 100 mg/L ZVI, 33.2 mg/L ozone, 300 mA applied current and 25 min reaction time.	Iron	64-68	prolyl endopeptidase	Homo sapiens	70-73
29108649-3	2017	In murine Ngb, a large internal cavity is involved in the heme sliding mechanism to achieve binding of gaseous ligands through coordination to the heme iron.	Iron	152-156	neuroglobin	Mus musculus	10-13
28319068-3	2017	Ferroportin (FPN), the iron efflux pump, is decreased, and transferrin receptor (TFR1), the iron importer, is increased in tumor tissue from patients with high grade but not low grade serous ovarian cancer.	Iron	92-96	transferrin receptor	Homo sapiens	59-79
28319068-3	2017	Ferroportin (FPN), the iron efflux pump, is decreased, and transferrin receptor (TFR1), the iron importer, is increased in tumor tissue from patients with high grade but not low grade serous ovarian cancer.	Iron	92-96	transferrin receptor	Homo sapiens	81-85
30212672-2	2018	The operational parameters of photoelectro-peroxone/zero valent iron (PEP/ZVI) process were studied and the complete decoloration was found at pH = 3.0, 100 mg/L ZVI, 33.2 mg/L ozone, 300 mA applied current and 25 min reaction time.	Iron	162-165	prolyl endopeptidase	Homo sapiens	70-73
28751976-1	2017	SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal transporter family, has been reported to mediate the cellular uptake of iron and zinc.	Iron	147-151	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-8
28751976-1	2017	SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal transporter family, has been reported to mediate the cellular uptake of iron and zinc.	Iron	147-151	solute carrier family 39 (zinc transporter), member 14	Mus musculus	24-29
29201641-4	2018	Three (3) single nucleotide polymorphisms (SNPs) associated with iron regulation were genotyped: two SNPs in the human hereditary hemochromatosis protein gene HFE: rs1800562 (C282Y mutation) and rs1799945 (H63D mutation), as well as the rs1049296 SNP in the transferrin gene (C2 mutation).	Iron	65-69	homeostatic iron regulator	Homo sapiens	119-153
30212672-4	2018	ZVI showed high reusability in PEP/ZVI process.	Iron	0-3	prolyl endopeptidase	Homo sapiens	31-34
29201641-4	2018	Three (3) single nucleotide polymorphisms (SNPs) associated with iron regulation were genotyped: two SNPs in the human hereditary hemochromatosis protein gene HFE: rs1800562 (C282Y mutation) and rs1799945 (H63D mutation), as well as the rs1049296 SNP in the transferrin gene (C2 mutation).	Iron	65-69	homeostatic iron regulator	Homo sapiens	159-162
31458326-5	2018	To exploit this idea, here, in the present work, we have synthesized semiconducting Ag2S nanoparticles and successfully doped them with different transition metals like Mn, Fe, Co, and Ni to study their electrocatalytic activity for the hydrogen evolution reaction from neutral water (pH = 7).	Iron	173-175	angiotensin II receptor type 1	Homo sapiens	84-88
29291011-2	2017	We conducted a thorough, large-scale investigation of the expression and prognostic significance of the primary iron uptake protein, transferrin receptor 1 (TfR1/CD71/TFRC), in RCC patients.	Iron	112-116	transferrin receptor	Homo sapiens	162-166
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	69-73	frataxin	Homo sapiens	147-150
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	182-186	NFS1 cysteine desulfurase	Homo sapiens	5-9
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	182-186	frataxin	Homo sapiens	137-145
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	182-186	frataxin	Homo sapiens	147-150
29291011-2	2017	We conducted a thorough, large-scale investigation of the expression and prognostic significance of the primary iron uptake protein, transferrin receptor 1 (TfR1/CD71/TFRC), in RCC patients.	Iron	112-116	transferrin receptor	Homo sapiens	167-171
20301613-0	1993	HFE-Associated Hereditary Hemochromatosis CLINICAL CHARACTERISTICS: HFE-associated hereditary hemochromatosis (HFE-HH) is characterized by inappropriately high absorption of iron by the gastrointestinal mucosa.	Iron	174-178	homeostatic iron regulator	Homo sapiens	0-3
20301613-0	1993	HFE-Associated Hereditary Hemochromatosis CLINICAL CHARACTERISTICS: HFE-associated hereditary hemochromatosis (HFE-HH) is characterized by inappropriately high absorption of iron by the gastrointestinal mucosa.	Iron	174-178	homeostatic iron regulator	Homo sapiens	68-71
28905281-0	2017	Enhanced degradation of acid red 1 dye using a coupled system of zero valent iron nanoparticles and sonolysis.	Iron	77-81	adenosine deaminase RNA specific B1	Homo sapiens	29-34
28905281-1	2017	The heterogeneous catalytic degradation of a model azo dye, acid red 1 (AR1), initiated by zero valent iron nanoparticles (ZVINP), and its synergic effect with ultrasound (US) have been investigated in the present study.	Iron	103-107	adenosine deaminase RNA specific B1	Homo sapiens	65-70
28445245-1	2017	BACKGROUND: Lipocalin-2 (Lcn2) is a multifunctional innate immune protein that exhibits antimicrobial activity by the sequestration of bacterial siderophores, regulates iron homeostasis, and augments cellular tolerance to oxidative stress.	Iron	169-173	lipocalin 2	Mus musculus	25-29
20301613-1	1993	The phenotypic spectrum of HFE-HH is now recognized to include: Those with clinical HFE-HH, in which manifestations of end-organ damage secondary to iron storage are present; Those with biochemical HFE-HH, in which the only evidence of iron overload is increased transferrin-iron saturation and increased serum ferritin concentration; Non-expressing p.Cys282Tyr homozygotes, in whom neither clinical manifestations of HFE-HH nor iron overload is present.	Iron	149-153	homeostatic iron regulator	Homo sapiens	27-30
20301613-1	1993	The phenotypic spectrum of HFE-HH is now recognized to include: Those with clinical HFE-HH, in which manifestations of end-organ damage secondary to iron storage are present; Those with biochemical HFE-HH, in which the only evidence of iron overload is increased transferrin-iron saturation and increased serum ferritin concentration; Non-expressing p.Cys282Tyr homozygotes, in whom neither clinical manifestations of HFE-HH nor iron overload is present.	Iron	236-240	homeostatic iron regulator	Homo sapiens	27-30
28406842-4	2017	In this study, we analyzed iron metabolism in 100 healthy Polish children in relation to their HFE gene status.	Iron	27-31	homeostatic iron regulator	Homo sapiens	95-98
28406842-7	2017	The mean concentration of iron, the level of ferritin, and transferrin saturation were statistically higher in the group of HFE variants compared with the wild-type group.	Iron	26-30	homeostatic iron regulator	Homo sapiens	124-127
29036620-6	2017	Expression analysis using FE-inducible systems and chromatin immunoprecipitation assays showed that FE directly bound to the FT and NaKR1 promoters and activated the transcription of downstream target genes.	Iron	100-102	Heavy metal transport/detoxification superfamily protein	Arabidopsis thaliana	132-137
29036620-7	2017	FE failed to activate FT expression without CO function, whereas FE-mediated NaKR1 induction was not affected by CO function.	Iron	65-67	Heavy metal transport/detoxification superfamily protein	Arabidopsis thaliana	77-82
28406842-9	2017	Male HFE carriers presented with higher iron concentration, transferrin saturation, and ferritin levels than females.	Iron	40-44	homeostatic iron regulator	Homo sapiens	5-8
20301613-1	1993	The phenotypic spectrum of HFE-HH is now recognized to include: Those with clinical HFE-HH, in which manifestations of end-organ damage secondary to iron storage are present; Those with biochemical HFE-HH, in which the only evidence of iron overload is increased transferrin-iron saturation and increased serum ferritin concentration; Non-expressing p.Cys282Tyr homozygotes, in whom neither clinical manifestations of HFE-HH nor iron overload is present.	Iron	236-240	homeostatic iron regulator	Homo sapiens	27-30
20301613-1	1993	The phenotypic spectrum of HFE-HH is now recognized to include: Those with clinical HFE-HH, in which manifestations of end-organ damage secondary to iron storage are present; Those with biochemical HFE-HH, in which the only evidence of iron overload is increased transferrin-iron saturation and increased serum ferritin concentration; Non-expressing p.Cys282Tyr homozygotes, in whom neither clinical manifestations of HFE-HH nor iron overload is present.	Iron	236-240	homeostatic iron regulator	Homo sapiens	27-30
20301613-2	1993	Clinical HFE-HH is characterized by excessive storage of iron in the liver, skin, pancreas, heart, joints, and testes.	Iron	57-61	homeostatic iron regulator	Homo sapiens	9-12
20301613-5	1993	DIAGNOSIS/TESTING: The diagnosis of clinical HFE-HH in individuals with clinical findings consistent with HFE-HH and the diagnosis of biochemical HFE-HH are typically based on finding elevated transferrin-iron saturation 45% or higher and serum ferritin concentration above the upper limit of normal (i.e., &gt;300 ng/mL in men and &gt;200 ng/mL in women) and two pathogenic variants on confirmatory HFE molecular genetic testing.	Iron	205-209	homeostatic iron regulator	Homo sapiens	45-48
28105984-1	2017	In this study, a novel composite containing an iron based metal-organic framework (MOF) and BiOBr was successfully synthesized by a simple method, and was fully characterized by X-ray diffraction patterns, Fourier transform infrared spectra, UV-vis diffuse reflectance spectra, and transmission electron microscopy.	Iron	47-51	lysine acetyltransferase 8	Homo sapiens	58-97
28443478-5	2017	Oxidative stress, secondary to the influx of hemoglobin, heme, and iron during retrograde menstruation, is involved in the expression of CpG demethylases, ten-eleven translocation, and jumonji (JMJ).	Iron	67-71	jumonji and AT-rich interaction domain containing 2	Homo sapiens	185-192
28443478-5	2017	Oxidative stress, secondary to the influx of hemoglobin, heme, and iron during retrograde menstruation, is involved in the expression of CpG demethylases, ten-eleven translocation, and jumonji (JMJ).	Iron	67-71	jumonji and AT-rich interaction domain containing 2	Homo sapiens	194-197
30588469-2	2018	We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic resonance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI.	Iron	123-127	glutamic--pyruvic transaminase	Homo sapiens	81-105
28834022-0	2017	Protonation of Ferrocene: A Low-Temperature X-ray Diffraction Study of [Cp2 FeH](PF6 ) Reveals an Iron-Bound Hydrido Ligand.	Iron	98-102	sperm associated antigen 17	Homo sapiens	81-84
29296759-3	2017	Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endocytosis of diferric-transferrin into recycling endosomes, where ferric iron is released, reduced, and exported to the cytosol via DMT1.	Iron	20-24	transferrin receptor	Homo sapiens	58-78
29296759-3	2017	Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endocytosis of diferric-transferrin into recycling endosomes, where ferric iron is released, reduced, and exported to the cytosol via DMT1.	Iron	20-24	transferrin receptor	Homo sapiens	80-84
29296759-4	2017	However, mice lacking TfR1 or DMT1 demonstrate residual erythropoiesis, suggesting additional pathways for iron use.	Iron	107-111	transferrin receptor	Mus musculus	22-26
29296759-4	2017	However, mice lacking TfR1 or DMT1 demonstrate residual erythropoiesis, suggesting additional pathways for iron use.	Iron	107-111	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	30-34
28834022-1	2017	Ferrocene, Cp2 Fe, is quantitatively protonated in a mixture of liquid HF/PF5 to yield [Cp2 FeH](PF6 ), which was characterized by 1 H/13 C NMR and 57 Fe Mossbauer spectroscopy as well as single-crystal X-ray diffraction analysis.	Iron	0-2	sperm associated antigen 17	Homo sapiens	97-100
28864672-0	2017	The coproporphyrin ferrochelatase of Staphylococcus aureus: mechanistic insights into a regulatory iron-binding site.	Iron	99-103	AT695_RS08245	Staphylococcus aureus	19-33
28864672-1	2017	The majority of characterised ferrochelatase enzymes catalyse the final step of classical haem synthesis, inserting ferrous iron into protoporphyrin IX.	Iron	116-128	AT695_RS08245	Staphylococcus aureus	30-44
28622511-4	2017	The protective effect of FTH is exerted via a mechanism that counters iron-driven oxidative inhibition of the liver glucose-6-phosphatase (G6Pase), and in doing so, sustains endogenous glucose production via liver gluconeogenesis.	Iron	70-74	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	116-137
28622511-4	2017	The protective effect of FTH is exerted via a mechanism that counters iron-driven oxidative inhibition of the liver glucose-6-phosphatase (G6Pase), and in doing so, sustains endogenous glucose production via liver gluconeogenesis.	Iron	70-74	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	139-145
30506659-0	2018	In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen.	Iron	32-36	glucose-6-phosphate dehydrogenase	Rattus norvegicus	71-104
28874556-9	2017	Structural docking experiments revealed that the epsilon ring of lutein fits into the active site of RPE65 close to the nonheme iron center.	Iron	128-132	RPE65, retinoid isomerohydrolase	Gallus gallus	101-106
30506659-5	2018	The aim of this study is to provide a better in vivo and in vitro understanding of how long-term iron overload affects the gene expression and activities of some antioxidant enzymes, such as glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) in the spleen.	Iron	97-101	glucose-6-phosphate dehydrogenase	Rattus norvegicus	191-224
29018170-7	2017	To test whether transient TRPV channel permeability in neural crest cells was sufficient to induce these defects, we engineered iron-binding modifications to TRPV1 and TRPV4 that enabled remote and noninvasive activation of these channels in specific cellular locations and at specific developmental times in chick embryos with radio-frequency electromagnetic fields.	Iron	128-132	transient receptor potential cation channel subfamily V member 4	Gallus gallus	168-173
28497772-4	2017	The modification of Fe-incorporated nitrogen-rich-carbons (Fe-CNx) on CNTs lowers the ORR half-wave-potential by ~190 mV, giving this catalyst with an onset ORR potential of 0.95 V (versus reversible hydrogen electrode (RHE)), a half-wave potential of 0.82 V (versus RHE), and the limiting current density of 5.39 mA cm-2 in 0.1 M KOH.	Iron	20-22	calnexin	Homo sapiens	62-65
30506659-5	2018	The aim of this study is to provide a better in vivo and in vitro understanding of how long-term iron overload affects the gene expression and activities of some antioxidant enzymes, such as glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) in the spleen.	Iron	97-101	glucose-6-phosphate dehydrogenase	Rattus norvegicus	226-230
30506659-6	2018	The findings of this study show that iron overload reduces the gene expression of G6pd, 6pgd, and Gr, but its actual effect was on the protein level.	Iron	37-41	glucose-6-phosphate dehydrogenase	Rattus norvegicus	82-86
30380148-5	2018	Meanwhile, the release of mitochondrial cytochrome c was significantly increased after iron overload and consequently triggered an apoptosis signal, as revealed by Caspase 3 cleavage.	Iron	87-91	caspase 3	Rattus norvegicus	164-173
27936945-2	2017	The rate of release of heme-iron is related to the tissue oxidative stress that can elicit deleterious effects in clinical uses of blood substitutes.	Iron	28-32	HEME	Bos taurus	23-27
29085625-5	2017	The dioxygen-dependent cleavage of the C6 and C1 bond in myo-Inositol is achieved by utilizing the Fe2+/Fe3+ binuclear iron center of MIOX.	Iron	119-123	myo-inositol oxygenase	Homo sapiens	134-138
30427936-7	2018	These findings were supported by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype.	Iron	205-209	transferrin receptor	Mus musculus	148-170
27882824-5	2017	Inhibition of MPP crystallization by iron and aluminium was confirmed by precipitation experiments and SEM-EDX analysis.	Iron	37-41	M-phase phosphoprotein 6	Homo sapiens	14-17
27931173-6	2017	The highest COD removal was obtained using finer ZVI (Hepure Ferrox Target) for doses of reagents ZVI/H2O2 1500/1600 mg/L, in a H2O2/COD weight ratio 2:1, at pH 3.0 with stirring on a magnetic stirrer.	Iron	49-52	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	12-15
27931173-6	2017	The highest COD removal was obtained using finer ZVI (Hepure Ferrox Target) for doses of reagents ZVI/H2O2 1500/1600 mg/L, in a H2O2/COD weight ratio 2:1, at pH 3.0 with stirring on a magnetic stirrer.	Iron	49-52	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	128-136
28219768-1	2017	Mosaic mutant mice displaying functional dysfunction of Atp7a copper transporter (the Menkes ATPase) are an established animal model of Menkes disease and constitute a convenient tool for investigating connections between copper and iron metabolisms.	Iron	233-237	dynein, axonemal, heavy chain 8	Mus musculus	93-99
27931173-6	2017	The highest COD removal was obtained using finer ZVI (Hepure Ferrox Target) for doses of reagents ZVI/H2O2 1500/1600 mg/L, in a H2O2/COD weight ratio 2:1, at pH 3.0 with stirring on a magnetic stirrer.	Iron	98-101	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	12-15
28276700-0	2017	Iron acquisition through the bacterial transferrin receptor.	Iron	0-4	transferrin receptor	Homo sapiens	39-59
27931173-8	2017	It was found that the efficiency of the process depends, as in the case of the Fenton process, on the ratio of the reagents (ZVI/H2O2) and their dose in relation to the COD (H2O2/COD) but does not depend on the dose of the iron itself.	Iron	125-128	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	169-172
30427936-7	2018	These findings were supported by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype.	Iron	205-209	transferrin receptor	Mus musculus	172-176
27931173-8	2017	It was found that the efficiency of the process depends, as in the case of the Fenton process, on the ratio of the reagents (ZVI/H2O2) and their dose in relation to the COD (H2O2/COD) but does not depend on the dose of the iron itself.	Iron	125-128	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	174-182
27931173-9	2017	Statistical analysis confirms that COD removal efficiency depends primarily on H2O2/COD ratio and ZVI granulation, but ZVI dose influence is not statistically significant.	Iron	98-101	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	35-38
28276700-6	2017	We also outline several of the remaining unanswered questions about iron uptake via the bacterial transferrin receptor and suggest directions for future research.	Iron	68-72	transferrin receptor	Homo sapiens	98-118
30281034-5	2018	Tf, Hpx and Hp are being developed for hematological disorders where iron, hemin and Hb contribute to pathophysiology.	Iron	69-73	hemopexin	Homo sapiens	4-7
28408167-5	2017	Rainbow trout TF has two functional iron-binding sites and appears to be quite distinct from carp TF regarding glycosylation and iron-binding properties.	Iron	36-40	transferrin-a	Oncorhynchus mykiss	14-16
28373265-2	2017	The steroid abiraterone, the active form of the only CYP17A1 inhibitor approved by the Food and Drug Administration, binds the catalytic heme iron, nonselectively impeding both reactions and ultimately causing undesirable corticosteroid imbalance.	Iron	142-146	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	53-60
28373265-5	2017	Binding studies and X-ray structures of CYP17A1 with nonsteroidal inhibitors reveal coordination to the heme iron like the steroidal inhibitors.	Iron	109-113	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	40-47
28840425-7	2017	However, in the recombinant cells that showed higher intracellular iron levels than wild-type cells, HFE and HAMP expressions were elevated only at low 1 g/L treatment (p &lt; 0.03) and were repressed at 2 g/L treatment (p &lt; 0.03).	Iron	67-71	homeostatic iron regulator	Homo sapiens	101-104
28840425-8	2017	Under holotransferrin-untreated conditions, the iron-loaded recombinant cells showed higher expressions of HFE (p &lt; 0.03) and HAMP (p = 0.05) than wild-type cells.	Iron	48-52	homeostatic iron regulator	Homo sapiens	107-110
28840425-9	2017	HFE mRNA was independently elevated by extracellular and intracellular iron-excess.	Iron	71-75	homeostatic iron regulator	Homo sapiens	0-3
28373265-9	2017	While active-site iron coordination is consistent with competitive inhibition, conformational selection for binding of some inhibitors and the differential presence of a peripheral ligand molecule suggest the possibility of CYP17A1 functional modulation by features outside the active site.	Iron	18-22	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	224-231
30232412-9	2018	Both Ret-He and MCV correlated with brain iron status at P14 and P15.	Iron	42-46	SUB1 regulator of transcription	Rattus norvegicus	57-60
28424258-3	2017	Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin"s diagnostic potential as an index of iron deficiency.Methods: We measured hemoglobin and serum hepcidin, ferritin, soluble transferrin receptor (sTfR), and C-reactive protein (CRP) at 14, 20, and 30 wk of gestation in a cohort of 395 Gambian women recruited to a randomized controlled trial.	Iron	0-4	transferrin receptor	Homo sapiens	392-412
28929467-0	2017	Erratum to: HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication.	Iron	81-85	homeostatic iron regulator	Homo sapiens	12-15
30416449-7	2018	Results: Greater efficiency was attained in the HFE PedM broilers by greater weight gain on the same amount of feed consumed resulting in FEs of 0.65 +- 0.01 and 0.46 +- 0.01 in the HFE and LFE phenotypes, respectively.	Iron	138-141	homeostatic iron regulator	Homo sapiens	48-51
28407591-2	2017	TEM, XRD, and BET characterization tests showed that FeS coating on the surface of Fe0 inhibited the aggregation of Fe0 and that Fe/FeS at a S/Fe molar ratio of 0.207 possessed a large surface area of 62.1m2/g.	Iron	53-56	delta/notch like EGF repeat containing	Homo sapiens	14-17
28407591-2	2017	TEM, XRD, and BET characterization tests showed that FeS coating on the surface of Fe0 inhibited the aggregation of Fe0 and that Fe/FeS at a S/Fe molar ratio of 0.207 possessed a large surface area of 62.1m2/g.	Iron	132-135	delta/notch like EGF repeat containing	Homo sapiens	14-17
27736268-2	2017	Iron complexed to transferrin is delivered to the metabolism after endocytosis via the CD71 surface receptor.	Iron	0-4	transferrin receptor	Mus musculus	87-91
30961033-2	2018	In this work, the endohedral fullerene C60 with incapsulated iron atom (endometallofullerene Fe@C60) is used for modification of P84 copolyimide.	Iron	61-65	THO complex 1	Homo sapiens	129-132
28167288-7	2017	Quantitative real-time polymerase chain reaction demonstrated significant dysregulation of genes involved in iron and heme metabolism, including Hmox1, Fech, Abcb7, and Sf3b1 downregulation.	Iron	109-113	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	158-163
28768766-10	2017	Conversely, expression of either IRP induced FBXL5 protein level, demonstrating a negative feedback loop limiting excessive accumulation of iron-response element RNA-binding activity, whose disruption reduces cell growth.	Iron	140-144	Wnt family member 2	Homo sapiens	33-36
30961033-2	2018	In this work, the endohedral fullerene C60 with incapsulated iron atom (endometallofullerene Fe@C60) is used for modification of P84 copolyimide.	Iron	93-95	THO complex 1	Homo sapiens	129-132
29927322-5	2018	Rats fed an iron-deficient diet for 4 wk also displayed significant decrease in liver Hamp expression and liver HFE protein content.	Iron	12-16	homeostatic iron regulator	Rattus norvegicus	112-115
28795723-4	2017	Intracellular iron is targeted to the mitochondria for incorporation into a porphyrin ring to form heme and cytosolic iron-sulfur proteins, including Iron Regulatory Protein 1 (IRP1).	Iron	14-18	aconitase 1	Homo sapiens	150-175
28795723-4	2017	Intracellular iron is targeted to the mitochondria for incorporation into a porphyrin ring to form heme and cytosolic iron-sulfur proteins, including Iron Regulatory Protein 1 (IRP1).	Iron	14-18	aconitase 1	Homo sapiens	177-181
28280078-1	2017	Mutations in the HFE (hemochromatosis) gene cause hereditary hemochromatosis, an iron overload disorder that is hallmarked by excessive accumulation of iron in parenchymal organs.	Iron	81-85	homeostatic iron regulator	Homo sapiens	17-20
28280078-1	2017	Mutations in the HFE (hemochromatosis) gene cause hereditary hemochromatosis, an iron overload disorder that is hallmarked by excessive accumulation of iron in parenchymal organs.	Iron	152-156	homeostatic iron regulator	Homo sapiens	17-20
28375153-0	2017	PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.	Iron	35-39	nuclear receptor coactivator 4	Mus musculus	10-15
29927322-11	2018	NEW &amp; NOTEWORTHY Feeding of iron-deficient diet for 4 wk decreased liver HFE protein content in both mice and rats, suggesting that decreased HFE-dependent signaling may contribute to hepcidin downregulation in iron deficiency.	Iron	32-36	homeostatic iron regulator	Rattus norvegicus	146-149
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	26-30	nuclear receptor coactivator 4	Mus musculus	157-187
30027360-10	2018	Tfr1, Dmt1, ferritin and ferroportin1 exist in bone tissue of rats, and they may be involved in the pathological process of iron overload-induced bone lesion.	Iron	124-128	transferrin receptor	Rattus norvegicus	0-4
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	26-30	nuclear receptor coactivator 4	Mus musculus	189-194
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	94-98	nuclear receptor coactivator 4	Mus musculus	189-194
28375153-6	2017	Using a cultured cell model of erythroid differentiation, depletion of PCBP1 or NCOA4 impaired iron trafficking through ferritin, which resulted in reduced heme synthesis, reduced hemoglobin formation, and perturbation of erythroid regulatory systems.	Iron	95-99	nuclear receptor coactivator 4	Mus musculus	80-85
28375153-9	2017	These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin.	Iron	173-177	nuclear receptor coactivator 4	Mus musculus	154-159
30169712-5	2018	Methods: Nonanemic, hippocampus-specific neuronal ID was generated by using a Tet-OFF dominant negative transferrin receptor (DN-TFR1) mouse model that impairs cellular iron uptake.	Iron	169-173	transferrin receptor	Mus musculus	104-124
27940234-2	2017	Specifically, we prepared iron doped polyacrylic hydrazide modified reduced graphene nanocomposites (Fe@RGO/PAH) by in-situ polymerization approach and subsequent a one-pot reaction with hydrazine.	Iron	26-30	phenylalanine hydroxylase	Homo sapiens	108-111
27940234-3	2017	The resulting Fe@RGO/PAH nanocomposites displayed low nonspecific adsorption to analytes (11% quenching caused by nonspecific adsorption) due to electrostatic, energetic and steric effect of the nanocomposites.	Iron	14-16	phenylalanine hydroxylase	Homo sapiens	21-24
30104344-11	2018	We demonstrated that S-nitrosylation increased DMT1-mediated Fe2+ uptake, and two cysteines were identified by mass spectrometry to be the sites for S-nitrosylation and for enhanced iron uptake.	Iron	182-186	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	47-51
28323419-4	2017	Here, we show that deletion of central components of the ISC system in addition to IscS leads to an overall decrease in Fe-S cluster enzyme and molybdoenzyme activity in addition to a decrease in the number of Fe-S-dependent thiomodifications of tRNA, based on the fact that some proteins involved in Moco biosynthesis and tRNA thiolation are Fe-S-dependent.	Iron	120-124	NFS1 cysteine desulfurase	Homo sapiens	83-87
28323419-4	2017	Here, we show that deletion of central components of the ISC system in addition to IscS leads to an overall decrease in Fe-S cluster enzyme and molybdoenzyme activity in addition to a decrease in the number of Fe-S-dependent thiomodifications of tRNA, based on the fact that some proteins involved in Moco biosynthesis and tRNA thiolation are Fe-S-dependent.	Iron	210-214	NFS1 cysteine desulfurase	Homo sapiens	83-87
28323419-4	2017	Here, we show that deletion of central components of the ISC system in addition to IscS leads to an overall decrease in Fe-S cluster enzyme and molybdoenzyme activity in addition to a decrease in the number of Fe-S-dependent thiomodifications of tRNA, based on the fact that some proteins involved in Moco biosynthesis and tRNA thiolation are Fe-S-dependent.	Iron	210-214	NFS1 cysteine desulfurase	Homo sapiens	83-87
30254296-7	2018	We discovered that cell death occurs through a YAP-independent mechanism, predominately involving binding of free iron and likely through redox cycling, contributes to production of reactive oxygen species.	Iron	114-118	Yes1 associated transcriptional regulator	Homo sapiens	47-50
28383065-5	2017	The Fe-doped nickel hydroxide hierarchical nanoarrays (Ni2.2Fe(OH)x HNAs), which had an appropriate elemental composition and hierarchical nanostructures, achieve the lowest onset overpotential of 234 mV and the smallest Tafel slope of 64.3 mV dec-1.	Iron	4-6	deleted in esophageal cancer 1	Homo sapiens	244-249
30235829-1	2018	The long distance transport of Fe and Zn in the phloem sap of wheat (Triticum aestivum L.) is the key route for seed supply, due to wheat having a xylem discontinuity.	Iron	31-33	thiosulfate sulfurtransferase 16, chloroplastic	Triticum aestivum	55-58
28375145-2	2017	3HAO is a non-heme iron-containing, ring-cleaving extradiol dioxygenase that catalyzes the addition of both atoms of O2 to the kynurenine pathway metabolite 3-hydroxyanthranilic acid (3-HANA) to form quinolinic acid (QUIN).	Iron	19-23	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	0-4
30235829-2	2018	To date, our knowledge is limited on Fe and Zn homeostasis in the phloem sap during the reproductive and grain filling stages.	Iron	37-39	thiosulfate sulfurtransferase 16, chloroplastic	Triticum aestivum	73-76
29768045-9	2018	This acute model of iron overload was associated with increased numbers of MFehi ATMs; 17% could be attributed to monocyte recruitment and 83% to MFelo ATM incorporation into the MFehi pool.	Iron	20-24	ataxia telangiectasia mutated	Mus musculus	81-84
28103400-7	2017	In contrast, the knockout of potential Fe-S scaffold proteins, NFU2 and HCF101, resulted in a specific decrease in the PsaA/B and PsaC levels.	Iron	39-43	ATP binding protein	Arabidopsis thaliana	72-78
28103400-7	2017	In contrast, the knockout of potential Fe-S scaffold proteins, NFU2 and HCF101, resulted in a specific decrease in the PsaA/B and PsaC levels.	Iron	39-43	photosystem I subunit VII	Arabidopsis thaliana	130-134
28103409-4	2017	ZmFDR4 is homologous to the bacterial FliP superfamily, coexisted in both algae and terrestrial plants, and capable of restoring the normal growth of the yeast mutant fet3fet4, which possesses defective Fe uptake systems.	Iron	203-205	ferroxidase FET3	Saccharomyces cerevisiae S288C	167-175
29768045-10	2018	The MFehi ATM population maintained its low inflammatory profile and iron-cycling expression profile.	Iron	69-73	ataxia telangiectasia mutated	Mus musculus	10-13
29656314-1	2018	Primary iron overload (IO) is commonly associated with mutations in the hereditary hemochromatosis gene (HFE).	Iron	8-12	homeostatic iron regulator	Homo sapiens	105-108
28069738-2	2017	We previously showed that mice with systemic deficiency of FBXL5 fail to sense intracellular iron levels and die in utero at embryonic day 8.5 (E8.5) as a result of iron overload and subsequent oxidative stress.	Iron	93-97	F-box and leucine-rich repeat protein 5	Mus musculus	59-64
28069738-2	2017	We previously showed that mice with systemic deficiency of FBXL5 fail to sense intracellular iron levels and die in utero at embryonic day 8.5 (E8.5) as a result of iron overload and subsequent oxidative stress.	Iron	165-169	F-box and leucine-rich repeat protein 5	Mus musculus	59-64
29656314-12	2018	In conclusion, CC homozygosis in the SNP - 174 G&gt;C gene promoter of IL-6 can be proposed as one of the gene variants influencing iron accumulation in male adults with HFE mutations.	Iron	132-136	homeostatic iron regulator	Homo sapiens	170-173
30031876-1	2018	Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN).	Iron	27-31	NFS1 cysteine desulfurase	Homo sapiens	83-87
28271877-2	2017	The initial sulfur mobilization step for FeS cluster biosynthesis is catalyzed by l-cysteine desulfurase NFS1, a reaction that is localized in mitochondria in humans.	Iron	41-44	NFS1 cysteine desulfurase	Homo sapiens	105-109
28271877-4	2017	The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for FeS cluster formation.	Iron	141-144	NFS1 cysteine desulfurase	Homo sapiens	4-8
28271877-4	2017	The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for FeS cluster formation.	Iron	141-144	frataxin	Homo sapiens	90-98
30031876-1	2018	Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN).	Iron	27-31	CPAT1	Homo sapiens	135-138
30031876-1	2018	Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN).	Iron	27-31	frataxin	Homo sapiens	188-196
28231705-6	2017	Importantly, the study demonstrates that C-8 addition products of (+)-catechin are promoted by Cu(II), whereas C-6 addition products are promoted by Fe ions.	Iron	149-151	complement C6	Homo sapiens	111-114
30031876-1	2018	Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN).	Iron	27-31	frataxin	Homo sapiens	198-201
30031876-2	2018	FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S cluster biosynthesis.	Iron	91-95	frataxin	Homo sapiens	0-3
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	125-127	DNA polymerase iota	Homo sapiens	131-135
30031876-2	2018	FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S cluster biosynthesis.	Iron	91-95	NFS1 cysteine desulfurase	Homo sapiens	14-18
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	125-127	DNA polymerase iota	Homo sapiens	136-140
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	42-46	DNA polymerase iota	Homo sapiens	72-76
30031876-2	2018	FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S cluster biosynthesis.	Iron	91-95	CPAT1	Homo sapiens	25-28
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	42-46	DNA polymerase iota	Homo sapiens	77-81
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	66-68	DNA polymerase iota	Homo sapiens	72-76
30031876-4	2018	Recent studies also reported a substitution at position Met141 on the yeast ISCU orthologue Isu, to Ile, Leu, Val, or Cys, could bypass the requirement of FXN for Fe-S cluster biosynthesis and cell viability.	Iron	163-167	frataxin	Homo sapiens	155-158
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	66-68	DNA polymerase iota	Homo sapiens	77-81
29782976-2	2018	The biogenesis of Fe-S clusters is orchestrated by ISC system; the sulfur donor IscS and scaffold protein IscU being its core components.	Iron	18-22	NFS1 cysteine desulfurase	Homo sapiens	80-84
30195681-6	2018	The iron solubility of the clays were in the order of KGa-2 &gt; SWy-2 &gt; CCa-2 &gt; IMt-2 &gt; NAu-2.	Iron	4-8	crystallin beta B2	Homo sapiens	76-81
27911488-2	2017	The 2 well recognized HCC risk factors in thalassemia are iron overload and chronic viral infection with hepatitis C. The carcinogenicity of iron is related to its induction of oxidative damage, which results in genotoxicity, and to immunologic dysregulation, which attenuates cancer immune surveillance.	Iron	58-62	HCC	Homo sapiens	22-25
27911488-2	2017	The 2 well recognized HCC risk factors in thalassemia are iron overload and chronic viral infection with hepatitis C. The carcinogenicity of iron is related to its induction of oxidative damage, which results in genotoxicity, and to immunologic dysregulation, which attenuates cancer immune surveillance.	Iron	141-145	HCC	Homo sapiens	22-25
27911488-4	2017	Screening patients who have thalassemia using magnetic resonance imaging-based liver iron concentration measurement and liver ultrasound is recommended for early detection of iron overload and HCC, respectively.	Iron	85-89	HCC	Homo sapiens	193-196
30018160-0	2018	Iron Overload Exacerbates the Risk of Hemorrhagic Transformation After tPA (Tissue-Type Plasminogen Activator) Administration in Thromboembolic Stroke Mice.	Iron	0-4	plasminogen activator, tissue	Mus musculus	76-109
28649081-2	2017	The serum level of transferrin receptor protein (sTfR) represents true demand of iron in the body.	Iron	81-85	transferrin receptor	Homo sapiens	19-39
30016095-3	2018	Iron import channels Fet1 and Fet3 are prominent in all three profiles.	Iron	0-4	ferroxidase FET3	Saccharomyces cerevisiae S288C	30-34
27856053-2	2017	The characterization by XRD, SEM-EDX and BET-N2 adsorption demonstrated that Fe, Cu/Fe and Mn/Fe nano particles were successfully loaded onto NaY zeolite and exhibited larger BET surface area compared to nano-Fe0 (nZVI).	Iron	77-79	delta/notch like EGF repeat containing	Homo sapiens	41-44
27856053-2	2017	The characterization by XRD, SEM-EDX and BET-N2 adsorption demonstrated that Fe, Cu/Fe and Mn/Fe nano particles were successfully loaded onto NaY zeolite and exhibited larger BET surface area compared to nano-Fe0 (nZVI).	Iron	77-79	delta/notch like EGF repeat containing	Homo sapiens	175-178
29784379-5	2018	Fe and Mn binding capacities on a SPR-IDA gel disc are less than 0.1 micromoles, which means that they are far below those on a Chelex-100 gel disc (around 3.2 mumoles), while competition with stronger binding metals such as Cu and Cd further lowers Fe and Mn capacities.	Iron	0-2	sepiapterin reductase	Homo sapiens	34-37
29784379-8	2018	The capacities of Fe and Mn on a ground Chelex-100 resin gel disc are around 1.6 micromoles, more than 16 times higher than the capacity on SPR-IDA gel disc.	Iron	18-20	sepiapterin reductase	Homo sapiens	140-143
28193224-5	2017	Mechanicistically, we identified Ireb2 (a master gene for intracellular iron delivery that encodes for IRP2 protein), as a novel miR-29 target.	Iron	72-76	iron-responsive element-binding protein 2	Nothobranchius furzeri	33-38
29980601-3	2018	Persulfide dioxygenase (PDO or ETHE1) is a mononuclear non-heme iron-containing protein in the sulfide oxidation pathway catalyzing the conversion of GSH persulfide (GSSH) to sulfite and GSH.	Iron	64-68	ETHE1 persulfide dioxygenase	Homo sapiens	31-36
27903581-0	2017	The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human beta-cells.	Iron	84-88	solute carrier family 39 member 14	Homo sapiens	42-47
27903581-4	2017	In the present study, we assessed the contribution of the metal-ion transporters ZRT/IRT-like protein 14 and 8 (ZIP14 and ZIP8) and divalent metal-ion transporter-1 (DMT1) to iron uptake by human beta-cells.	Iron	175-179	solute carrier family 39 member 14	Homo sapiens	81-110
28928459-5	2017	Data from rodent models indicate that interleukin-27 modifies neutrophil maturation in the bone marrow, suppressing their production of pro-inflammatory/cytotoxic products while increasing their production of beneficial iron-scavenging molecules, including lactoferrin.	Iron	220-224	interleukin 27	Homo sapiens	38-52
29404495-0	2017	Nicotinamide N-methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes.	Iron	57-61	nicotinamide N-methyltransferase	Homo sapiens	0-32
27903581-4	2017	In the present study, we assessed the contribution of the metal-ion transporters ZRT/IRT-like protein 14 and 8 (ZIP14 and ZIP8) and divalent metal-ion transporter-1 (DMT1) to iron uptake by human beta-cells.	Iron	175-179	solute carrier family 39 member 14	Homo sapiens	112-117
29858915-2	2018	Here we show that in the SP6 acupuncture point (Sanyinjiao) the Fe ions are in a high-spin state of approximately t2g4.5eg1.5 in an Fe-N(O) octahedral crystal field.	Iron	64-66	Sp6 transcription factor	Homo sapiens	25-28
27903581-4	2017	In the present study, we assessed the contribution of the metal-ion transporters ZRT/IRT-like protein 14 and 8 (ZIP14 and ZIP8) and divalent metal-ion transporter-1 (DMT1) to iron uptake by human beta-cells.	Iron	175-179	solute carrier family 39 member 8	Homo sapiens	122-126
27903529-6	2017	Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2fl/fl (Bmp2LSECKO) mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis.	Iron	114-118	stabilin 2	Mus musculus	61-66
27903529-6	2017	Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2fl/fl (Bmp2LSECKO) mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis.	Iron	161-165	stabilin 2	Mus musculus	61-66
27903529-6	2017	Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2fl/fl (Bmp2LSECKO) mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis.	Iron	161-165	stabilin 2	Mus musculus	61-66
28673786-7	2017	Moreover, the results showed a network in which diurnal variations in systemic iron levels were tightly regulated by hepcidin and Tf/TfR via DCYTB and DMT1.	Iron	79-83	solute carrier family 11 member 2	Sus scrofa	151-155
28828587-6	2017	Furthermore, inhibition of AMPK or p38 reduced the ability of tryptanthrin to prevent AA + iron-induced cell death and mitochondrial dysfunction.	Iron	91-95	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	27-31
29858915-2	2018	Here we show that in the SP6 acupuncture point (Sanyinjiao) the Fe ions are in a high-spin state of approximately t2g4.5eg1.5 in an Fe-N(O) octahedral crystal field.	Iron	132-134	Sp6 transcription factor	Homo sapiens	25-28
28031527-3	2017	TICs also show activation of the IRP/IRE system, leading to higher iron uptake and decrease in iron storage, suggesting that level of properly assembled cytosolic iron-sulfur clusters (FeS) is reduced.	Iron	67-71	Wnt family member 2	Homo sapiens	33-36
29858915-3	2018	The Fe K-edge synchrotron radiation X-ray absorption fine structure results reveal that the Fe-N and Fe-O bond lengths in the SP6 acupuncture point are 2.05 and 2.13 A, respectively, and are 0.05-0.10 A longer than those in the surrounding tissue.	Iron	4-6	Sp6 transcription factor	Homo sapiens	126-129
28031527-3	2017	TICs also show activation of the IRP/IRE system, leading to higher iron uptake and decrease in iron storage, suggesting that level of properly assembled cytosolic iron-sulfur clusters (FeS) is reduced.	Iron	95-99	Wnt family member 2	Homo sapiens	33-36
28031527-3	2017	TICs also show activation of the IRP/IRE system, leading to higher iron uptake and decrease in iron storage, suggesting that level of properly assembled cytosolic iron-sulfur clusters (FeS) is reduced.	Iron	95-99	Wnt family member 2	Homo sapiens	33-36
28989623-4	2017	Here, we report an ENDOR study of the crystallographically characterized biomimetic iron(i) complex 1, which exhibits eta2 coordination of styrene, thus connecting hyperfine and structural parameters of an Fe-bound alkene fragment for the first time.	Iron	206-208	DNA polymerase iota	Homo sapiens	118-122
28031527-3	2017	TICs also show activation of the IRP/IRE system, leading to higher iron uptake and decrease in iron storage, suggesting that level of properly assembled cytosolic iron-sulfur clusters (FeS) is reduced.	Iron	185-188	Wnt family member 2	Homo sapiens	33-36
29858915-3	2018	The Fe K-edge synchrotron radiation X-ray absorption fine structure results reveal that the Fe-N and Fe-O bond lengths in the SP6 acupuncture point are 2.05 and 2.13 A, respectively, and are 0.05-0.10 A longer than those in the surrounding tissue.	Iron	92-96	Sp6 transcription factor	Homo sapiens	126-129
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	aconitase 1	Homo sapiens	194-198
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	homeostatic iron regulator	Homo sapiens	228-231
29546482-0	2018	Genome-wide and comparative analysis of bHLH38, bHLH39, bHLH100 and bHLH101 genes in Arabidopsis, tomato, rice, soybean and maize: insights into iron (Fe) homeostasis.	Iron	145-149	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	68-75
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	transferrin receptor	Homo sapiens	250-254
28059071-1	2017	Secondary active transporters of the SLC11/NRAMP family catalyse the uptake of iron and manganese into cells.	Iron	79-83	solute carrier family 34 member 1	Homo sapiens	37-42
28724340-2	2017	FRDA is caused by deficits in the production and expression of frataxin, a protein found in the mitochondria that is most likely responsible for regulating iron-sulfur cluster enzymes within the cell.	Iron	156-160	frataxin	Homo sapiens	0-4
28724340-2	2017	FRDA is caused by deficits in the production and expression of frataxin, a protein found in the mitochondria that is most likely responsible for regulating iron-sulfur cluster enzymes within the cell.	Iron	156-160	frataxin	Homo sapiens	63-71
28724340-3	2017	A decrease in frataxin causes dysfunction of adenosine triphosphate synthesis, accumulation of mitochondrial iron, and other events leading to downstream cellular dysfunction.	Iron	109-113	frataxin	Homo sapiens	14-22
29546482-0	2018	Genome-wide and comparative analysis of bHLH38, bHLH39, bHLH100 and bHLH101 genes in Arabidopsis, tomato, rice, soybean and maize: insights into iron (Fe) homeostasis.	Iron	151-153	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	68-75
29546482-5	2018	In this study, we aimed to understand the roles of bHLH38, bHLH39, bHLH100 and bHLH101 genes for Fe homeostasis in Arabidopsis, tomato, rice, soybean and maize species by using bioinformatics approaches.	Iron	97-99	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	79-86
30014253-2	2018	Our recent studies highlighted that apart from ubiquitous roles of Hsf1 at higher temperatures, it also has myriad non-heat shock responsive roles essential under iron deprivation and drug defense.	Iron	163-167	heat shock transcription factor 1	Homo sapiens	67-71
27578012-3	2017	Here, we systematically investigated iron content and the expression of two major iron importers, transferrin receptor 1 (TfR1) and divalent metal transporter (DMT1), two iron exporters, ferroportin 1 (Fpn1) and ceruloplasmin (CP), and hepcidin, along with the pathological hallmarks of Parkinson"s (PD) and Alzheimer"s diseases (AD) in the brain of young (3 months), adult (12 months), and aged (24 months) rats.	Iron	82-86	transferrin receptor	Rattus norvegicus	98-120
27578012-3	2017	Here, we systematically investigated iron content and the expression of two major iron importers, transferrin receptor 1 (TfR1) and divalent metal transporter (DMT1), two iron exporters, ferroportin 1 (Fpn1) and ceruloplasmin (CP), and hepcidin, along with the pathological hallmarks of Parkinson"s (PD) and Alzheimer"s diseases (AD) in the brain of young (3 months), adult (12 months), and aged (24 months) rats.	Iron	82-86	transferrin receptor	Rattus norvegicus	98-120
28631167-1	2017	KEY MESSAGE: Copper deficiency and excess differentially affect iron homeostasis in rice and overexpression of the Arabidopsis high-affinity copper transporter COPT1 slightly increases endogenous iron concentration in rice grains.	Iron	64-68	copper transporter 1	Arabidopsis thaliana	160-165
28631167-1	2017	KEY MESSAGE: Copper deficiency and excess differentially affect iron homeostasis in rice and overexpression of the Arabidopsis high-affinity copper transporter COPT1 slightly increases endogenous iron concentration in rice grains.	Iron	196-200	copper transporter 1	Arabidopsis thaliana	160-165
28101095-5	2016	Suppression of cytosolic APX by RNAi in cotton increased ASC contents and delayed tissue browning by maintaining ferric reduction activity under Fe-deficient conditions.	Iron	145-147	L-ascorbate peroxidase, cytosolic-like	Gossypium hirsutum	25-28
27272717-8	2017	Coexistence of iron and copper was supported by good correlations in the molecular ratios between these two metals in iron-rich particles with Cu x-ray image.	Iron	15-19	cut like homeobox 1	Homo sapiens	143-147
27272717-8	2017	Coexistence of iron and copper was supported by good correlations in the molecular ratios between these two metals in iron-rich particles with Cu x-ray image.	Iron	118-122	cut like homeobox 1	Homo sapiens	143-147
27272717-10	2017	In conclusion, the iron-rich particles with Cu x-ray image were found in the ACP brain.	Iron	19-23	cut like homeobox 1	Homo sapiens	44-48
30014253-5	2018	For instance, Hsf1 binding was observed on several genes of oxidative and osmotic stress response, cell wall integrity, iron homeostasis, mitochondrial, hyphal and multidrug transporters.	Iron	120-124	heat shock transcription factor 1	Homo sapiens	14-18
29962146-4	2018	SEM, EDS, and BET analysis demonstrated that the BET specific surface areas for the iron- and manganese-rich oxides were 96 m2 g-1 and 67 m2 g-1, respectively, with the former accumulated between the pore spaces of the filtering sand and easily washed out of the layer by backwashing, whereas the latter coated the surface of the filtering sand.	Iron	84-88	delta/notch like EGF repeat containing	Homo sapiens	14-17
29225212-4	2017	In this study, we found that treatment of cells with an iron-specific chelator deferoxamine (DFO) increased reactive oxidative species (ROS) production by elevating the expression of p47phox and p67phox compared with that in untreated cells.	Iron	56-60	neutrophil cytosolic factor 2	Homo sapiens	195-202
28835670-4	2017	In this study, we showed that the protein encoded by ARABIDOPSIS THALIANA PLANT DEFENSIN TYPE 1.1 (AtPDF1.1) is a secreted protein that can chelate apoplastic iron.	Iron	159-163	low-molecular-weight cysteine-rich 67	Arabidopsis thaliana	99-107
29081812-7	2017	PIC1 also inhibited heme destruction by NaOCl for RBC lysates, hemoglobin, and myoglobin as assayed by preservation of the Soret absorbance peak in the presence of NaOCl and reduction in free iron release.	Iron	192-196	small ubiquitin like modifier 1	Homo sapiens	0-4
29050310-9	2017	In PC12 cells, the miR-27b inhibitor diminished iron-induced oxidative stress, inflammation and apoptosis, and those effects were blocked by Nrf2 knockdown.	Iron	48-52	microRNA 27b	Rattus norvegicus	19-26
29962146-4	2018	SEM, EDS, and BET analysis demonstrated that the BET specific surface areas for the iron- and manganese-rich oxides were 96 m2 g-1 and 67 m2 g-1, respectively, with the former accumulated between the pore spaces of the filtering sand and easily washed out of the layer by backwashing, whereas the latter coated the surface of the filtering sand.	Iron	84-88	delta/notch like EGF repeat containing	Homo sapiens	49-52
30002810-7	2018	Analysis of iron homeostatic proteins revealed increased expression of IRP1, Tf, ferritin and TfR in N171-82Q mice striatum and cortex.	Iron	12-16	transferrin receptor	Mus musculus	94-97
28699008-2	2018	It was found that Fe-based MOF (MIL-102) is a potential precursor for the fabrication of hexagonal mesoporous carbon nanodisk functionalized with Fe3O4 nanoparticles.	Iron	18-20	lysine acetyltransferase 8	Homo sapiens	27-30
28516506-1	2017	The geometric and electronic ground-state structures of 30 isomers of six MS4 molecules (M=Group 8 metals Fe, Ru, Os, Hs, Sm, and Pu) have been studied by using quantum-chemical density functional theory and correlated wavefunction approaches.	Iron	106-108	MS4	Homo sapiens	74-77
27747853-8	2017	RESULTS: Cardiomyocytes exposed to gradually reduced iron concentrations in the medium demonstrated a decrease in the mRNA expression of FTH, FTL, FPN1, MB, and HAMP (all R = -0.75, p &lt; 0.05), indicating depleted iron status in the cells.	Iron	53-57	myoglobin	Rattus norvegicus	153-155
27747853-9	2017	As a consequence, the expression of TfR1 (R = 0.7, p &lt; 0.05) was increased, reflecting a facilitated entrance of iron to the cells.	Iron	116-120	transferrin receptor	Rattus norvegicus	36-40
28608291-0	2017	Iron-induced generation of mitochondrial ROS depends on AMPK activity.	Iron	0-4	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	56-60
29377294-1	2018	Ceruloplasmin (Cp), an enzyme containing six copper atoms, has important roles in iron homeostasis and antioxidant defense.	Iron	82-86	ceruloplasmin	Rattus norvegicus	0-13
28608291-5	2017	Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS.	Iron	108-112	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	30-58
28608291-5	2017	Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS.	Iron	108-112	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	60-64
28608291-6	2017	By contrast, AMPK inhibition aggravated the neurotoxicity of iron and enhanced the production of mitochondrial ROS.	Iron	61-65	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	13-17
28608291-7	2017	Collectively, these findings suggested that excess iron may be able to perturb mitochondrial function, and AMPK activity is important for the association of iron and mitochondria.	Iron	157-161	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	107-111
29223935-1	2017	Excess iron (Fe) intake in subjects carrying certain mutations in the HFE gene may result in Fe overload.	Iron	7-11	homeostatic iron regulator	Homo sapiens	70-73
29223935-1	2017	Excess iron (Fe) intake in subjects carrying certain mutations in the HFE gene may result in Fe overload.	Iron	13-15	homeostatic iron regulator	Homo sapiens	70-73
29223935-1	2017	Excess iron (Fe) intake in subjects carrying certain mutations in the HFE gene may result in Fe overload.	Iron	93-95	homeostatic iron regulator	Homo sapiens	70-73
28882209-5	2017	Recently, we identified cytosolic aconitase/iron regulatory protein 1 (IRP1) as the first physiological protein acceptor of the mitoNEET Fe-S cluster in an Fe-S repair process.	Iron	137-141	aconitase 1	Homo sapiens	71-75
28882209-5	2017	Recently, we identified cytosolic aconitase/iron regulatory protein 1 (IRP1) as the first physiological protein acceptor of the mitoNEET Fe-S cluster in an Fe-S repair process.	Iron	156-160	aconitase 1	Homo sapiens	71-75
29883959-0	2018	Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.	Iron	108-112	hephaestin	Mus musculus	18-28
28398093-8	2017	The overall FCR was significantly better in birds fed on the mid-Fe diets with phytase supplementation.	Iron	65-67	FCR	Gallus gallus	12-15
28606572-10	2017	Intake of phosphorus, calcium, zinc, magnesium, iron, and vitamin B12 during the luteal phase was positively correlated with serum DAO activity (P &lt; 0.05).	Iron	48-52	amine oxidase copper containing 1	Homo sapiens	131-134
29883959-7	2018	These data indicate that HEPH and CP play mutually compensatory roles in facilitating iron efflux from the exocrine pancreas, and show that MCFs are able to protect the pancreas against iron-induced oxidative damage.	Iron	86-90	hephaestin	Mus musculus	25-29
29883959-7	2018	These data indicate that HEPH and CP play mutually compensatory roles in facilitating iron efflux from the exocrine pancreas, and show that MCFs are able to protect the pancreas against iron-induced oxidative damage.	Iron	186-190	hephaestin	Mus musculus	25-29
27814974-0	2017	Iron related hemochromatosis (HFE) gene mutations in Friedreich Ataxia patients.	Iron	0-4	homeostatic iron regulator	Homo sapiens	30-33
29575577-2	2018	We generated and characterized hepatocyte-specific Smad7 knockout mice (Smad7Alb/Alb ), which showed decreased serum iron, tissue iron, haemoglobin concentration, up-regulated hepcidin and increased phosphor-Smad1/5/8 levels in both isolated primary hepatocytes and liver tissues.	Iron	117-121	SMAD family member 7	Mus musculus	51-56
29575577-2	2018	We generated and characterized hepatocyte-specific Smad7 knockout mice (Smad7Alb/Alb ), which showed decreased serum iron, tissue iron, haemoglobin concentration, up-regulated hepcidin and increased phosphor-Smad1/5/8 levels in both isolated primary hepatocytes and liver tissues.	Iron	117-121	albumin	Mus musculus	72-84
29576242-8	2018	However, upon the addition of both l-cysteine and a reductant (either reduced FDX2 or DTT), Fe2+ is released from FXN as consistent with Fe2+-FXN being the proximal source of iron for Fe-S cluster assembly.	Iron	92-94	frataxin	Homo sapiens	114-117
27991585-0	2016	Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.	Iron	40-44	hephaestin	Mus musculus	0-10
29459227-0	2018	Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation.	Iron	84-88	NADPH oxidase 4	Homo sapiens	70-74
27991585-5	2016	The non-heme iron content both in the renal cortex and medulla of Heph/Cp KO mice was significantly increased.	Iron	13-17	hephaestin	Mus musculus	66-70
27991585-6	2016	Perls" Prussian blue staining showed iron accumulation on the apical side of renal tubular cells in Heph/Cp KO mice.	Iron	37-41	hephaestin	Mus musculus	100-104
27991585-10	2016	These results suggest that KO of both the HEPH and CP genes leads to kidney iron deposition and toxicity, MCFs could protect kidney against a damage from iron excess.	Iron	76-80	hephaestin	Mus musculus	42-46
29898548-2	2018	Iron supported on activated carbon (Fe/ACP, Fe/ACN and Fe/ACNS) were prepared and worked as catalyst for catalytic wet peroxide oxidation of benzoic acid (BA).	Iron	0-4	CPAT1	Homo sapiens	39-42
27892575-6	2016	The transition from the FeN4 structure to metallic Fe results in a significant loss in ORR activity and an increase in the production of undesirable HO2- during catalysis.	Iron	24-26	heme oxygenase 2	Homo sapiens	149-152
29771935-6	2018	Indeed, in vitro macrophage iron loading reduced the basal percentage of cells expressing M1 co-stimulatory CD86 and MHC-II molecules.	Iron	28-32	CD86 molecule	Homo sapiens	108-112
29771935-7	2018	Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression.	Iron	9-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	123-126
27934434-0	2016	Characterization of Ground State Electron Configurations of High-Spin Quintet Ferrous Heme Iron in Deoxy Myoglobin Reconstituted with Trifluoromethyl Group-Substituted Heme Cofactors.	Iron	91-95	myoglobin	Physeter catodon	105-114
29654211-2	2018	We previously developed a mouse/human chimeric IgG3 Ab (ch128.1) targeting human TfR1, which exhibits direct in vitro cytotoxicity against certain human malignant B cells through TfR1 degradation and iron deprivation.	Iron	200-204	Immunoglobulin heavy constant gamma 3	Mus musculus	47-51
29654211-2	2018	We previously developed a mouse/human chimeric IgG3 Ab (ch128.1) targeting human TfR1, which exhibits direct in vitro cytotoxicity against certain human malignant B cells through TfR1 degradation and iron deprivation.	Iron	200-204	transferrin receptor	Homo sapiens	81-85
28028679-6	2016	A differential impact of the two HFE variants was further noticed with the observation of a significantly higher percentage of p.Cys282Tyr heterozygous patients presenting tissue iron deposition in comparison to p.His63Asp heterozygous.	Iron	179-183	homeostatic iron regulator	Homo sapiens	33-36
29604179-1	2018	In the yeast Saccharomyces cerevisiae Aft1, the low iron-sensing transcription factor is known to regulate the expression of the FET3 gene.	Iron	52-56	ferroxidase FET3	Saccharomyces cerevisiae S288C	129-133
28028679-8	2016	Although limited by a low sampling size, our results provide a new possible explanation for the previously reported impact of HFE major variants on breast cancer progression, i.e., not by influencing systemic iron homeostasis but rather by differentially modulating the local cellular expression of iron-related proteins and tissue iron deposition.	Iron	209-213	homeostatic iron regulator	Homo sapiens	126-129
28028679-8	2016	Although limited by a low sampling size, our results provide a new possible explanation for the previously reported impact of HFE major variants on breast cancer progression, i.e., not by influencing systemic iron homeostasis but rather by differentially modulating the local cellular expression of iron-related proteins and tissue iron deposition.	Iron	299-303	homeostatic iron regulator	Homo sapiens	126-129
28028679-8	2016	Although limited by a low sampling size, our results provide a new possible explanation for the previously reported impact of HFE major variants on breast cancer progression, i.e., not by influencing systemic iron homeostasis but rather by differentially modulating the local cellular expression of iron-related proteins and tissue iron deposition.	Iron	299-303	homeostatic iron regulator	Homo sapiens	126-129
29604179-5	2018	We suggest that the activation of FET3 by Ace1 prevents the hyper activation of Aft1, possibly by assuring the adequate functioning of mitochondrial iron-sulfur cluster biogenesis.	Iron	149-153	ferroxidase FET3	Saccharomyces cerevisiae S288C	34-38
29604179-6	2018	While reinforcing the link between iron and copper homeostasis, this work unveils a novel protection mechanism against copper toxicity mediated by Ace1, which relies in the activation of FET3 and results in the restriction of Aft1 activity as a means to prevent excessive copper accumulation.	Iron	35-39	ferroxidase FET3	Saccharomyces cerevisiae S288C	187-191
29452354-2	2018	In yeast, the membrane-bound heterodimer Fet3/Ftr1 is the high affinity iron importer.	Iron	72-76	ferroxidase FET3	Saccharomyces cerevisiae S288C	41-45
27647172-7	2016	Muscle non-heme iron (NHI) was increased in aged WT mice but not in aged Zip14 KO mice demonstrating NHI uptake by muscle is ZIP14-dependent and increases with age.	Iron	16-20	solute carrier family 39 (zinc transporter), member 14	Mus musculus	125-130
29452354-4	2018	When the concentration of external iron is low (<1 microM), Fet3/Ftr1 is maintained on the plasma membrane by retrograde endocytic-recycling; whereas, when the concentration of external iron is high (>10 microM), Fet3/Ftr1 is endocytosed and shunted to the vacuole for degradation.	Iron	35-39	ferroxidase FET3	Saccharomyces cerevisiae S288C	60-64
27518705-3	2016	Frataxin is important in mitochondrial iron-sulfur cluster (ISC) biogenesis and low-frataxin expression is due to a GAA repeat expansion in intron 1 of the FXN gene.	Iron	39-43	frataxin	Homo sapiens	0-8
29452354-4	2018	When the concentration of external iron is low (<1 microM), Fet3/Ftr1 is maintained on the plasma membrane by retrograde endocytic-recycling; whereas, when the concentration of external iron is high (>10 microM), Fet3/Ftr1 is endocytosed and shunted to the vacuole for degradation.	Iron	35-39	ferroxidase FET3	Saccharomyces cerevisiae S288C	213-217
29436580-7	2018	Depleted iron in cell culture combined with hypoxia also induced a decrease in SMAD4 expression (P&lt;0.001) suggesting modifications leading to atrophy.	Iron	9-13	SMAD family member 4	Homo sapiens	79-84
27871472-9	2016	DISCUSSION: In the placenta of NH, increases in expressions of TFR1, transferrin, and ferritin of which those of TFR1 were especially marked, reflect increased iron influx from the mother to fetus.	Iron	160-164	transferrin receptor	Homo sapiens	63-67
27871472-9	2016	DISCUSSION: In the placenta of NH, increases in expressions of TFR1, transferrin, and ferritin of which those of TFR1 were especially marked, reflect increased iron influx from the mother to fetus.	Iron	160-164	transferrin receptor	Homo sapiens	113-117
29248829-2	2018	The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective.	Iron	149-153	glial cell derived neurotrophic factor	Rattus norvegicus	188-191
27797496-4	2016	To improve our understanding of the molecular basis of the stimulatory effect of b5 and to test the hypothesis that b5 stimulates catalysis by more rapid protonation of the anionic ferric hydroperoxo heme intermediate of P450 (Fe3+OOH)- and subsequent formation of the active oxidizing species (Fe+4 O POR +), we have freeze-quenched the reaction mixture during a single turnover following reduction of oxyferrous P450 2B4 by each of its redox partners, b5 and P450 reductase.	Iron	227-229	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	221-225
29636509-0	2018	Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.	Iron	60-64	transmembrane serine protease 6	Mus musculus	0-12
28175303-3	2016	FRDA neurons showed lower levels of iron-sulfur (Fe-S) and lipoic acid-containing proteins, higher labile iron pool (LIP), higher expression of mitochondrial superoxide dismutase (SOD2), increased reactive oxygen species (ROS) and lower reduced glutathione (GSH) levels, and enhanced sensitivity to oxidants compared with CT neurons, indicating deficient Fe-S cluster biogenesis, altered iron metabolism, and oxidative stress.	Iron	355-359	frataxin	Homo sapiens	0-4
28175303-3	2016	FRDA neurons showed lower levels of iron-sulfur (Fe-S) and lipoic acid-containing proteins, higher labile iron pool (LIP), higher expression of mitochondrial superoxide dismutase (SOD2), increased reactive oxygen species (ROS) and lower reduced glutathione (GSH) levels, and enhanced sensitivity to oxidants compared with CT neurons, indicating deficient Fe-S cluster biogenesis, altered iron metabolism, and oxidative stress.	Iron	106-110	frataxin	Homo sapiens	0-4
28175303-4	2016	Treatment with the benzamide HDAC inhibitor 109 significantly upregulated FXN expression and increased Fe-S and lipoic acid-containing protein levels, downregulated SOD2 levels, normalized LIP and ROS levels, and almost fully protected FRDA neurons from oxidative stress-mediated cell death.	Iron	103-107	frataxin	Homo sapiens	236-240
29636509-6	2018	Rescue experiments that block hepcidin up-regulation and restore iron levels in Tmprss6-/- mice via anti-hemojuvelin (HJV) therapy, revert the obesity-resistant phenotype of Tmprss6-/- mice.	Iron	65-69	transmembrane serine protease 6	Mus musculus	80-87
28771247-5	2018	Our review of the published data from a variety of empirical sources indicates that roughly 1 in 10 male HFE C282Y homozygotes is likely to develop severe liver disease during his lifetime unless iron overload is detected early and treated.	Iron	196-200	homeostatic iron regulator	Homo sapiens	105-108
27808258-7	2016	Moreover, iron loading led to a 15% loss of olig2-positive cells and a 16% increase in number and greater activation of microglia compared with vehicle.	Iron	10-14	oligodendrocyte transcription factor 2	Homo sapiens	44-49
29305416-10	2018	To further explore eventual iron sequestration in macrophages, we produce a Gaucher cells model by treating the J774 macrophage cell line with a glucocerebrosidase inhibitor and showed induced local hepcidin and membrane retrieval of the iron exporter, ferroportin.	Iron	238-242	glucosidase, beta, acid	Mus musculus	145-163
27682429-4	2016	In contrast, such counterions as I5 , I3 , BF4 , SbF6 , and PF6 are found to be tightly associated with one of the porphyrin rings and, therefore, stabilize two different spin states of iron in one molecule.	Iron	186-190	sperm associated antigen 17	Homo sapiens	60-63
27991479-7	2016	The same challenges as elsewhere are faced in the GCC, with respect to optimizing Hb levels and judiciously using ESA and iron supplements.	Iron	122-126	guanylate cyclase 2C	Homo sapiens	50-53
29563373-8	2018	The occurrence of hemochromatosis in HS is extremely rare, and previous reports have shown that the coexistence of heterozygosity for the HFE gene mutation in HS patients causes excess iron storage.	Iron	185-189	homeostatic iron regulator	Homo sapiens	138-141
27956775-9	2016	CONCLUSION: In light of the fact that hepcidin plays a role function in the regulation of Fe as well as the fact that Fe is a significant nutritional source for many microorganisms, it was concluded that hepcidin may play a significant role in nutritional immunity and the pathogenesis of diseases.	Iron	90-92	hepcidin antimicrobial peptide	Bos taurus	38-46
27956775-9	2016	CONCLUSION: In light of the fact that hepcidin plays a role function in the regulation of Fe as well as the fact that Fe is a significant nutritional source for many microorganisms, it was concluded that hepcidin may play a significant role in nutritional immunity and the pathogenesis of diseases.	Iron	90-92	hepcidin antimicrobial peptide	Bos taurus	204-212
27956775-9	2016	CONCLUSION: In light of the fact that hepcidin plays a role function in the regulation of Fe as well as the fact that Fe is a significant nutritional source for many microorganisms, it was concluded that hepcidin may play a significant role in nutritional immunity and the pathogenesis of diseases.	Iron	118-120	hepcidin antimicrobial peptide	Bos taurus	204-212
29596470-0	2018	Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1alpha activation.	Iron	33-37	voltage dependent anion channel 1	Homo sapiens	108-113
27792144-7	2016	In addition, the expression of some Fe acquisition-related genes, including FIT1, FRO2, and IRT1 were significantly up-regulated by melatonin treatments, whereas the enhanced expression of these genes was obviously suppressed in the polyamine- and NO-deficient plants.	Iron	36-38	ferric reduction oxidase 2	Arabidopsis thaliana	82-86
29596470-10	2018	Interestingly, we show that hypoxia promotes the downregulation of several proteins (ISCU, NFS1, FXN) involved in the early steps of mitochondrial Fe-S cluster biogenesis.	Iron	147-151	NFS1 cysteine desulfurase	Homo sapiens	91-95
29596470-10	2018	Interestingly, we show that hypoxia promotes the downregulation of several proteins (ISCU, NFS1, FXN) involved in the early steps of mitochondrial Fe-S cluster biogenesis.	Iron	147-151	frataxin	Homo sapiens	97-100
27782493-9	2016	The calculated partial charges of the Fe atom for ground state FeS1-3- and Fe(SH)1-3- clusters are apparently related to and correlated with their determined first VDEs.	Iron	38-40	HSPA (Hsp70) binding protein 1	Homo sapiens	63-67
29596470-12	2018	Our results are the first to associate dysfunction in Fe-S cluster biogenesis with cleavage of VDAC1, a form which has previously been shown to promote tumor resistance to chemotherapy, and raise new perspectives for targets in cancer therapy.	Iron	54-58	voltage dependent anion channel 1	Homo sapiens	95-100
29572489-3	2018	Irp1 or Irp2-null mutation is known to reduce the cellular iron level by decreasing transferrin receptor 1 and increasing ferritin.	Iron	59-63	aconitase 1	Homo sapiens	0-4
27668828-6	2016	It is found that formation of the active WTR:CmlPAT-l-PAPA complex converts at least one iron of the cluster from six- to five-coordinate by changing a bidentately bound amino acid carboxylate to monodentate on Fe1.	Iron	89-93	pappalysin 1	Homo sapiens	54-58
29572489-4	2018	Here, we report that Irp1 or Irp2-null mutation also causes downregulation of frataxin and IscU, two of the core components in the iron-sulfur cluster biogenesis machinery.	Iron	131-135	aconitase 1	Homo sapiens	21-25
29572489-4	2018	Here, we report that Irp1 or Irp2-null mutation also causes downregulation of frataxin and IscU, two of the core components in the iron-sulfur cluster biogenesis machinery.	Iron	131-135	frataxin	Homo sapiens	78-86
27801326-4	2016	Iron overload was observed in 52(55.32%)of 94 MDS patients, in which a higher prevalence of iron overload was observed in low risk groups(IPSS low/Int-1 risk groups)than higher risk groups(Int-2/high risk groups).	Iron	0-4	fibroblast growth factor 3	Homo sapiens	189-194
29572489-6	2018	Overexpression of human ISCU and frataxin in Irp1 or Irp2-null cells was able to rescue the defects in iron-sulfur cluster biogenesis and mitochondrial quality.	Iron	103-107	frataxin	Homo sapiens	33-41
29572489-6	2018	Overexpression of human ISCU and frataxin in Irp1 or Irp2-null cells was able to rescue the defects in iron-sulfur cluster biogenesis and mitochondrial quality.	Iron	103-107	aconitase 1	Homo sapiens	45-49
29568068-1	2018	Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC) assembly.	Iron	196-200	frataxin	Homo sapiens	19-23
27623539-4	2016	The iron chelating capability of hPR-DFO was verified by UV-vis absorption spectroscopy and the ability of materials to degrade into smaller CD-conjugated DFO fragments (hCD-DFO) in the presence of the protease was confirmed via gel permeation chromatography.	Iron	4-8	haptoglobin-related protein	Homo sapiens	33-36
27623539-5	2016	In vitro studies in iron-overloaded macrophages reveal that hPR-DFO can significantly reduce the cytotoxicity of the drug while maintaining its chelation efficacy, and that it is more rapidly endocytosed and trafficked to lysosomes of iron-overloaded cells in comparison to non-iron-overloaded macrophages.	Iron	20-24	haptoglobin-related protein	Homo sapiens	60-63
27623539-5	2016	In vitro studies in iron-overloaded macrophages reveal that hPR-DFO can significantly reduce the cytotoxicity of the drug while maintaining its chelation efficacy, and that it is more rapidly endocytosed and trafficked to lysosomes of iron-overloaded cells in comparison to non-iron-overloaded macrophages.	Iron	235-239	haptoglobin-related protein	Homo sapiens	60-63
27623539-5	2016	In vitro studies in iron-overloaded macrophages reveal that hPR-DFO can significantly reduce the cytotoxicity of the drug while maintaining its chelation efficacy, and that it is more rapidly endocytosed and trafficked to lysosomes of iron-overloaded cells in comparison to non-iron-overloaded macrophages.	Iron	235-239	haptoglobin-related protein	Homo sapiens	60-63
27623539-6	2016	In vivo studies indicate that iron-overloaded mice treated with hPR-DFO displayed lower serum ferritin levels (a measure of iron burden in the body) and could eliminate excess iron by both the renal and fecal routes.	Iron	30-34	haptoglobin-related protein	Homo sapiens	64-67
27623539-6	2016	In vivo studies indicate that iron-overloaded mice treated with hPR-DFO displayed lower serum ferritin levels (a measure of iron burden in the body) and could eliminate excess iron by both the renal and fecal routes.	Iron	124-128	haptoglobin-related protein	Homo sapiens	64-67
27623539-6	2016	In vivo studies indicate that iron-overloaded mice treated with hPR-DFO displayed lower serum ferritin levels (a measure of iron burden in the body) and could eliminate excess iron by both the renal and fecal routes.	Iron	124-128	haptoglobin-related protein	Homo sapiens	64-67
29568068-1	2018	Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC) assembly.	Iron	196-200	frataxin	Homo sapiens	125-133
29541866-1	2018	PURPOSE: Transferrin receptor (TfR) is up-regulated in various malignant tumors not only to meet the iron requirement, but also to increase the cell survival via participation in various cellular signaling pathways.	Iron	101-105	transferrin receptor	Homo sapiens	9-29
27711215-7	2016	Interestingly, the clones showed also altered level of TfR1 and ferritin, indices of a modified iron homeostasis.	Iron	96-100	transferrin receptor	Mus musculus	55-59
27555240-8	2016	The iron(III) centers of the diethylpyrrole-bridged diiron(III) mu-oxo bisporphyrin undergo very strong antiferromagnetic interactions (J=-137.7 cm(-1) ), although the coupling constant is reduced to only a weak value in the mu-hydroxo complexes (J=-42.2, -44.1, and -42.4 cm(-1) for the BF4 , SbF6 , and PF6 complexes, respectively).	Iron	4-8	sperm associated antigen 17	Homo sapiens	305-308
29541866-1	2018	PURPOSE: Transferrin receptor (TfR) is up-regulated in various malignant tumors not only to meet the iron requirement, but also to increase the cell survival via participation in various cellular signaling pathways.	Iron	101-105	transferrin receptor	Homo sapiens	31-34
29900191-2	2018	We determined in S. cerevisiae the effects of mutation in the IBA57 gene on reactive oxygen species (ROS) and iron homeostasis.	Iron	110-114	Iba57p	Saccharomyces cerevisiae S288C	62-67
27656906-1	2016	Lithiation of hydrothermally synthesized Li1-xFex(OH)Fe1-ySe turns on high-temperature superconductivity when iron ions are displaced from the hydroxide layers by reductive lithiation to fill the vacancies in the iron selenide layers.	Iron	110-114	transglutaminase 1	Homo sapiens	41-44
29518107-4	2018	In details, four genes of iron homeostasis (Hemochromatosis (HFE: C282Y, H63D), Ferroportin (FPN1: -8CG), Hepcidin (HAMP: -582AG), Transferrin (TF: P570S)), and the three major alleles of APOE (APOE2, APOE3, APOE4) were analyzed to explore causative interactions and synergies.	Iron	26-30	homeostatic iron regulator	Homo sapiens	61-64
27667164-3	2016	Therefore, we created a novel cell line, recombinant-TfR1 HepG2, expressing iron-response-element-independent TFRC mRNA to promote cellular iron-overload and examined the effect of excess holotransferrin (5g/L) on cell-surface TfR1, iron content, hepcidin secretion and mRNA expressions of TFRC, HAMP, SLC40A1, HFE and TFR2.	Iron	76-80	transferrin receptor	Homo sapiens	53-57
27667164-3	2016	Therefore, we created a novel cell line, recombinant-TfR1 HepG2, expressing iron-response-element-independent TFRC mRNA to promote cellular iron-overload and examined the effect of excess holotransferrin (5g/L) on cell-surface TfR1, iron content, hepcidin secretion and mRNA expressions of TFRC, HAMP, SLC40A1, HFE and TFR2.	Iron	76-80	transferrin receptor	Homo sapiens	110-114
27667164-3	2016	Therefore, we created a novel cell line, recombinant-TfR1 HepG2, expressing iron-response-element-independent TFRC mRNA to promote cellular iron-overload and examined the effect of excess holotransferrin (5g/L) on cell-surface TfR1, iron content, hepcidin secretion and mRNA expressions of TFRC, HAMP, SLC40A1, HFE and TFR2.	Iron	140-144	transferrin receptor	Homo sapiens	53-57
27667164-3	2016	Therefore, we created a novel cell line, recombinant-TfR1 HepG2, expressing iron-response-element-independent TFRC mRNA to promote cellular iron-overload and examined the effect of excess holotransferrin (5g/L) on cell-surface TfR1, iron content, hepcidin secretion and mRNA expressions of TFRC, HAMP, SLC40A1, HFE and TFR2.	Iron	140-144	transferrin receptor	Homo sapiens	53-57
28195347-9	2017	Interestingly, solute carrier family 7, member 11 (Slc7a11), a known ferroptosis-related gene, was significantly up-regulated in iron-treated cells compared with untreated cells.	Iron	129-133	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	15-49
28195347-9	2017	Interestingly, solute carrier family 7, member 11 (Slc7a11), a known ferroptosis-related gene, was significantly up-regulated in iron-treated cells compared with untreated cells.	Iron	129-133	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	51-58
28195347-12	2017	CONCLUSION: We found that iron treatment induced ferroptosis in Slc7a11-/- cells, indicating that deleting Slc7a11 facilitates the onset of ferroptosis specifically under high-iron conditions; these results provide compelling evidence that iron plays a key role in triggering Slc7a11-mediated ferroptosis and suggest that ferroptosis may be a promising target for treating hemochromatosis-related tissue damage.	Iron	26-30	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	64-71
28195347-12	2017	CONCLUSION: We found that iron treatment induced ferroptosis in Slc7a11-/- cells, indicating that deleting Slc7a11 facilitates the onset of ferroptosis specifically under high-iron conditions; these results provide compelling evidence that iron plays a key role in triggering Slc7a11-mediated ferroptosis and suggest that ferroptosis may be a promising target for treating hemochromatosis-related tissue damage.	Iron	26-30	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	107-114
28195347-12	2017	CONCLUSION: We found that iron treatment induced ferroptosis in Slc7a11-/- cells, indicating that deleting Slc7a11 facilitates the onset of ferroptosis specifically under high-iron conditions; these results provide compelling evidence that iron plays a key role in triggering Slc7a11-mediated ferroptosis and suggest that ferroptosis may be a promising target for treating hemochromatosis-related tissue damage.	Iron	26-30	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	107-114
29518107-13	2018	We therefore extended to additional iron gene variants the newly proposed influencing mechanisms that HFE gene has on cholesterol metabolism.	Iron	36-40	homeostatic iron regulator	Homo sapiens	102-105
28195347-12	2017	CONCLUSION: We found that iron treatment induced ferroptosis in Slc7a11-/- cells, indicating that deleting Slc7a11 facilitates the onset of ferroptosis specifically under high-iron conditions; these results provide compelling evidence that iron plays a key role in triggering Slc7a11-mediated ferroptosis and suggest that ferroptosis may be a promising target for treating hemochromatosis-related tissue damage.	Iron	176-180	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	107-114
28195347-12	2017	CONCLUSION: We found that iron treatment induced ferroptosis in Slc7a11-/- cells, indicating that deleting Slc7a11 facilitates the onset of ferroptosis specifically under high-iron conditions; these results provide compelling evidence that iron plays a key role in triggering Slc7a11-mediated ferroptosis and suggest that ferroptosis may be a promising target for treating hemochromatosis-related tissue damage.	Iron	176-180	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	107-114
27403535-5	2016	Reduced erythropoietic iron utilization was characterized by down-regulation of the transferrin receptor 1 (TfR1) on reticulocytes and modest increased iron storage in the spleen.	Iron	23-27	transferrin receptor	Rattus norvegicus	84-106
29515198-2	2018	However Fe(Se,Te) thin films grown on CaF2 substrate result less anisotropic with respect to all the other iron based superconductors.	Iron	107-111	CCR4-NOT transcription complex subunit 8	Homo sapiens	38-42
27403535-5	2016	Reduced erythropoietic iron utilization was characterized by down-regulation of the transferrin receptor 1 (TfR1) on reticulocytes and modest increased iron storage in the spleen.	Iron	23-27	transferrin receptor	Rattus norvegicus	108-112
28195347-12	2017	CONCLUSION: We found that iron treatment induced ferroptosis in Slc7a11-/- cells, indicating that deleting Slc7a11 facilitates the onset of ferroptosis specifically under high-iron conditions; these results provide compelling evidence that iron plays a key role in triggering Slc7a11-mediated ferroptosis and suggest that ferroptosis may be a promising target for treating hemochromatosis-related tissue damage.	Iron	176-180	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	107-114
28195347-12	2017	CONCLUSION: We found that iron treatment induced ferroptosis in Slc7a11-/- cells, indicating that deleting Slc7a11 facilitates the onset of ferroptosis specifically under high-iron conditions; these results provide compelling evidence that iron plays a key role in triggering Slc7a11-mediated ferroptosis and suggest that ferroptosis may be a promising target for treating hemochromatosis-related tissue damage.	Iron	176-180	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	107-114
28211293-1	2017	BACKGROUND: Hereditary hemochromatosis gene (HFE) mutations have a role in iron overload in pediatric acute lymphoblastic leukemia (ALL) survivors.	Iron	75-79	homeostatic iron regulator	Homo sapiens	45-48
28211293-2	2017	We aimed to evaluate the genotype frequency and allelic distribution of the two HFE gene mutations (C282Y and H63D) in a sample of Egyptian pediatric ALL survivors and to detect the impact of these two mutations on their iron profile.	Iron	221-225	homeostatic iron regulator	Homo sapiens	80-83
27339324-1	2016	Hereditary hemochromatosis factor E (HFE) is a type 1 transmembrane protein, and acts as a negative regulator of iron-uptake.	Iron	113-117	homeostatic iron regulator	Homo sapiens	11-35
27339324-1	2016	Hereditary hemochromatosis factor E (HFE) is a type 1 transmembrane protein, and acts as a negative regulator of iron-uptake.	Iron	113-117	homeostatic iron regulator	Homo sapiens	37-40
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	89-93	NFS1 cysteine desulfurase	Homo sapiens	189-193
27380194-4	2016	Iron is a key molecule for regulating cytosolic aconitase 1 (ACO1).	Iron	0-4	aconitase 1	Homo sapiens	61-65
29296776-0	2017	Intestinal hephaestin potentiates iron absorption in weanling, adult, and pregnant mice under physiological conditions.	Iron	34-38	hephaestin	Mus musculus	11-21
29296776-3	2017	The process of iron uptake into duodenal enterocytes is relatively well understood, but less is known about the functional coupling between the iron exporter ferroportin 1 and the basolateral membrane iron oxidase hephaestin (Heph).	Iron	144-148	hephaestin	Mus musculus	214-224
28648056-2	2017	Recently, human mitoNEET has been shown to be implicated in Fe/S cluster repair of cytosolic iron regulatory protein 1 (IRP1), a key regulator of cellular iron homeostasis in mammalian cells.	Iron	93-97	aconitase 1	Homo sapiens	120-124
27380194-7	2016	We hypothesized that iron itself activates the ACO1-IDH pathway, which may increase 2-HG and DNA methylation, and eventually contribute to leukemogenesis without IDH mutation.	Iron	21-25	aconitase 1	Homo sapiens	47-51
27459537-0	2016	GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves beta-Cell Function in Type 2 Wolfram Syndrome.	Iron	39-43	glucagon like peptide 1 receptor	Homo sapiens	0-5
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	279-283	NFS1 cysteine desulfurase	Homo sapiens	189-193
27459537-13	2016	Treatment with GLP-1-RA, probably aided by iron chelation, should be considered in WFS and other forms of diabetes associated with iron dysregulation.	Iron	43-47	glucagon like peptide 1 receptor	Homo sapiens	15-20
27459537-13	2016	Treatment with GLP-1-RA, probably aided by iron chelation, should be considered in WFS and other forms of diabetes associated with iron dysregulation.	Iron	131-135	glucagon like peptide 1 receptor	Homo sapiens	15-20
28714470-0	2017	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.	Iron	42-46	F-box and leucine-rich repeat protein 5	Mus musculus	18-23
28714470-3	2017	Here we show that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal.	Iron	18-22	F-box and leucine-rich repeat protein 5	Mus musculus	55-60
28714470-4	2017	Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number.	Iron	64-68	F-box and leucine-rich repeat protein 5	Mus musculus	24-29
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	279-283	NFS1 cysteine desulfurase	Homo sapiens	189-193
29546308-13	2018	Whether these iron intakes perturb copper metabolism is worth considering, especially since copper defi-ciency can impair iron utilization (e.g., by decreasing the ferroxidase activity of ceruloplasmin).	Iron	14-18	ceruloplasmin	Rattus norvegicus	188-201
29137259-7	2017	In contrast, IRP1 knockdown does not affect iron homeostasis and only modestly affects cell growth, likely through an iron-independent mechanism.	Iron	118-122	aconitase 1	Homo sapiens	13-17
26545340-3	2016	Indeed, many proteins initially characterized in those diseases such as amyloid-beta protein, alpha-synuclein, and huntingtin have been linked to iron neurochemistry.	Iron	146-150	huntingtin	Homo sapiens	115-125
29378951-1	2018	Lipocalin-2 (Lcn2), a critical component of the innate immune response which binds siderophores and limits bacterial iron acquisition, can elicit spillover adverse proinflammatory effects.	Iron	117-121	lipocalin 2	Rattus norvegicus	0-11
27684894-5	2016	Following a cisgenic approach to produce transgenic homozygous barley line over-expressing HvHMA2 in the transfer cells of the grain, resulted in a doubling of a wide range of nutrients including Zn, iron (Fe), and magnesium (Mg) in the inner endosperm.	Iron	200-204	HMA2	Hordeum vulgare	91-97
27684894-5	2016	Following a cisgenic approach to produce transgenic homozygous barley line over-expressing HvHMA2 in the transfer cells of the grain, resulted in a doubling of a wide range of nutrients including Zn, iron (Fe), and magnesium (Mg) in the inner endosperm.	Iron	206-208	HMA2	Hordeum vulgare	91-97
28608694-10	2017	Together with three previous X-ray structures of iron complexes in the alphaalphabetabeta conformation, the structure of the cavity and the shape of the relaxed distal strap are also discussed with the consideration of the resolution of X-ray structures of two different free-base ligands in the alphaalphabetabeta conformation, with one bearing the ethyl malonate group and the second one bearing the malonic acid group.	Iron	49-53	serine/threonine kinase receptor associated protein	Homo sapiens	168-173
29378951-1	2018	Lipocalin-2 (Lcn2), a critical component of the innate immune response which binds siderophores and limits bacterial iron acquisition, can elicit spillover adverse proinflammatory effects.	Iron	117-121	lipocalin 2	Rattus norvegicus	13-17
28615255-1	2017	Background: Total body iron (TBI) that is calculated from ferritin and soluble transferrin receptor (sTfR) allows for the evaluation of the full range of iron status from deficiency to excess.	Iron	154-158	transferrin receptor	Homo sapiens	79-99
29378951-2	2018	Here we show that holo-Lcn2 (Lcn2-siderophore-iron, 1:3:1) increases mitochondrial reactive oxygen species (ROS) generation and attenuates mitochondrial oxidative phosphorylation in adult rat primary cardiomyocytes in a manner blocked by N-acetyl-cysteine or the mitochondria-specific antioxidant SkQ1.	Iron	46-50	lipocalin 2	Rattus norvegicus	23-27
28111930-0	2017	HFE gene mutation is a risk factor for tissue iron accumulation in hemodialysis patients.	Iron	46-50	homeostatic iron regulator	Homo sapiens	0-3
28111930-1	2017	INTRODUCTION: HFE gene mutations are responsible from iron overload in general population.	Iron	54-58	homeostatic iron regulator	Homo sapiens	14-17
28111930-3	2017	However effect of HFE mutations on iron overload in hemodialysis patients was not previously extensively studied.	Iron	35-39	homeostatic iron regulator	Homo sapiens	18-21
27557498-5	2016	We used gene expression data derived from a genetically defined model of Ewing sarcoma to interrogate the Connectivity Map and identify a class of drugs, iron chelators, that downregulate a significant number of EWS-FLI1 target genes.	Iron	154-158	EWS RNA binding protein 1	Homo sapiens	212-215
29378951-2	2018	Here we show that holo-Lcn2 (Lcn2-siderophore-iron, 1:3:1) increases mitochondrial reactive oxygen species (ROS) generation and attenuates mitochondrial oxidative phosphorylation in adult rat primary cardiomyocytes in a manner blocked by N-acetyl-cysteine or the mitochondria-specific antioxidant SkQ1.	Iron	46-50	lipocalin 2	Rattus norvegicus	29-33
28111930-12	2017	Iron overload was detected in five of eight patients who had HFE gene mutations, but iron overload was present in 4 of 28 patients who had no mutations (P = 0.01).	Iron	0-4	homeostatic iron regulator	Homo sapiens	61-64
28111930-14	2017	HFE gene mutations remained the main determinant of iron overload after multivariate logistic regression analysis (P = 0.02; OR, 11.6).	Iron	52-56	homeostatic iron regulator	Homo sapiens	0-3
27646472-10	2016	Overexpression of Kir6.2/SUR1 resulted in an increase in iron influx and intracellular iron levels, which was markedly increased after diazoxide treatment.	Iron	57-61	ATP binding cassette subfamily C member 8	Homo sapiens	25-29
29395073-3	2018	After studying fibroblast cell lines from subjects carrying both known and unreported biallelic mutations in CRAT and REPS1, we ascribe iron overload to the abnormal recycling of transferrin receptor (TfR1) and the reduction of TfR1 palmitoylation in NBIA.	Iron	136-140	RALBP1 associated Eps domain containing 1	Homo sapiens	118-123
27646472-10	2016	Overexpression of Kir6.2/SUR1 resulted in an increase in iron influx and intracellular iron levels, which was markedly increased after diazoxide treatment.	Iron	87-91	ATP binding cassette subfamily C member 8	Homo sapiens	25-29
27255319-2	2016	In that purpose, TiO2-iron-exchanged zeolite (FeZ) composite was prepared using commercial Aeroxide TiO2 P25 and iron-exchanged zeolite of ZSM5 type, FeZ.	Iron	22-26	FEZ family zinc finger 1	Homo sapiens	46-49
28604414-14	2017	Our suggestive finding that the association between dietary heme iron intake and risk of UC may be modified by a coding variant in FcgammaRIIA gene warrants additional investigation.	Iron	65-69	Fc gamma receptor IIa	Homo sapiens	131-142
28372951-4	2017	Compared with controls, allografts and recipient spleens derived from iron-overloaded recipients were characterized by a pronounced graft infiltration of CD4+ T cells (p &lt; 0.01), CD3-NKp46+ natural killer cells (p &lt; 0.05), and reduced frequencies of regulatory T cells (p &lt; 0.01).	Iron	70-74	CD3 antigen, epsilon polypeptide	Mus musculus	182-185
29395073-3	2018	After studying fibroblast cell lines from subjects carrying both known and unreported biallelic mutations in CRAT and REPS1, we ascribe iron overload to the abnormal recycling of transferrin receptor (TfR1) and the reduction of TfR1 palmitoylation in NBIA.	Iron	136-140	transferrin receptor	Homo sapiens	179-199
28372951-4	2017	Compared with controls, allografts and recipient spleens derived from iron-overloaded recipients were characterized by a pronounced graft infiltration of CD4+ T cells (p &lt; 0.01), CD3-NKp46+ natural killer cells (p &lt; 0.05), and reduced frequencies of regulatory T cells (p &lt; 0.01).	Iron	70-74	natural cytotoxicity triggering receptor 1	Mus musculus	186-191
27319012-0	2016	Common Bean Leaves as a Source of Dietary Iron: Functional Test in an Iron-Deficient Rat Model.	Iron	42-46	brain expressed, associated with NEDD4, 1	Rattus norvegicus	7-11
29395073-3	2018	After studying fibroblast cell lines from subjects carrying both known and unreported biallelic mutations in CRAT and REPS1, we ascribe iron overload to the abnormal recycling of transferrin receptor (TfR1) and the reduction of TfR1 palmitoylation in NBIA.	Iron	136-140	transferrin receptor	Homo sapiens	201-205
27319012-0	2016	Common Bean Leaves as a Source of Dietary Iron: Functional Test in an Iron-Deficient Rat Model.	Iron	70-74	brain expressed, associated with NEDD4, 1	Rattus norvegicus	7-11
29395073-3	2018	After studying fibroblast cell lines from subjects carrying both known and unreported biallelic mutations in CRAT and REPS1, we ascribe iron overload to the abnormal recycling of transferrin receptor (TfR1) and the reduction of TfR1 palmitoylation in NBIA.	Iron	136-140	transferrin receptor	Homo sapiens	228-232
29406047-5	2018	RESULTS: HSC expressed the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-export protein ferroportin.	Iron	27-31	transferrin receptor	Mus musculus	47-69
29406047-5	2018	RESULTS: HSC expressed the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-export protein ferroportin.	Iron	27-31	transferrin receptor	Mus musculus	71-75
28646124-0	2017	Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.	Iron	91-103	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	69-73
29024598-8	2018	Interactions between IRON and BCAA were observed for proteins indicative of mitochondrial biogenesis (peroxisome proliferator-activated receptor gamma coactivator 1 alpha) and oxidative capacity (cytochrome c oxidase subunit 2 and citrate synthase) (P &lt; 0.05) wherein the combined diet (BL) negated potential benefits of individual diets.	Iron	21-25	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	196-247
28548666-0	2017	Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe-S cluster assembly centers.	Iron	13-17	frataxin	Homo sapiens	24-32
28548666-3	2017	We previously showed that oligomerization is a mechanism by which yeast frataxin (Yfh1) can promote assembly of the core machinery for Fe-S cluster synthesis both in vitro and in cells, in such a manner that the scaffold protein, Isu1, can bind to Yfh1 independent of the presence of the cysteine desulfurase, Nfs1.	Iron	135-139	frataxin	Homo sapiens	72-80
28548666-7	2017	This configuration is suitable for docking of Nfs1 in a manner that provides a structural context for coordinate iron and sulfur donation to the scaffold.	Iron	113-117	NFS1 cysteine desulfurase	Homo sapiens	46-50
27537180-7	2016	Unexpectedly, however, high-iron (HFe) feeding also impaired growth.	Iron	28-32	homeostatic iron regulator	Rattus norvegicus	34-37
27537180-10	2016	Furthermore, higher copper levels in the HFe diet increased serum nonheme iron concentration and transferrin saturation, exacerbated hepatic nonheme iron loading and attenuated splenic nonheme iron accumulation.	Iron	74-78	homeostatic iron regulator	Rattus norvegicus	41-44
29355933-0	2018	Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.	Iron	52-56	hephaestin	Mus musculus	12-22
27226592-1	2016	Clathrin-mediated endocytosis of transferrin (Tf) and its cognate receptor (TfR1) is a central pathway supporting the uptake of trophic iron.	Iron	136-140	transferrin receptor	Homo sapiens	76-80
28674546-6	2017	Here, we report the discovery that an Arabidopsis thaliana monothiol glutaredoxin S17 (AtGRXS17) plays a critical role in the plants ability to respond to iron deficiency stress and maintain redox homeostasis.	Iron	155-159	thioredoxin family protein	Arabidopsis thaliana	87-95
28674546-7	2017	In a yeast expression assay, AtGRXS17 was able to suppress the iron accumulation in yeast ScGrx3/ScGrx4 mutant cells.	Iron	63-67	thioredoxin family protein	Arabidopsis thaliana	29-37
28674546-8	2017	Genetic analysis indicated that plants with reduced AtGRXS17 expression were hypersensitive to iron deficiency and showed increased iron concentrations in mature seeds.	Iron	95-99	thioredoxin family protein	Arabidopsis thaliana	52-60
28674546-8	2017	Genetic analysis indicated that plants with reduced AtGRXS17 expression were hypersensitive to iron deficiency and showed increased iron concentrations in mature seeds.	Iron	132-136	thioredoxin family protein	Arabidopsis thaliana	52-60
26813939-6	2016	RESULTS: There was a negative association between maternal BMI and iron status at enrollment (transferrin receptor (sTfR): r=0.20, P&lt;0.001; body iron (BI): r=-0.05; P=0.03).	Iron	67-71	transferrin receptor	Homo sapiens	94-114
29355933-7	2018	Together, these results demonstrate the protective roles of HEPH and CP in preventing iron overload in adipocytes.	Iron	86-90	hephaestin	Mus musculus	60-64
29101239-9	2018	Dietary iron repletion completely reversed ID anemia and ineffective erythropoiesis of Hri-/- , eAA, and Atf4-/- mice by inhibiting both HRI and mTORC1 signaling.	Iron	8-12	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	137-140
29101239-9	2018	Dietary iron repletion completely reversed ID anemia and ineffective erythropoiesis of Hri-/- , eAA, and Atf4-/- mice by inhibiting both HRI and mTORC1 signaling.	Iron	8-12	CREB regulated transcription coactivator 1	Mus musculus	145-151
27358414-10	2016	Duodenal mucosal tumor necrosis factor alpha (TNFA), interleukin (IL) 1beta, and IL6 relative gene expression was upregulated by 36%, 28%, and 45%, respectively, in H-Fe pigs (P &lt; 0.05), but not in L-Fe pigs, compared with A-Fe pigs.	Iron	167-169	tumor necrosis factor	Sus scrofa	17-44
28747430-1	2017	Ferredoxin reductase (FDXR), a target of p53, modulates p53-dependent apoptosis and is necessary for steroidogenesis and biogenesis of iron-sulfur clusters.	Iron	135-139	ferredoxin reductase	Mus musculus	0-20
28747430-1	2017	Ferredoxin reductase (FDXR), a target of p53, modulates p53-dependent apoptosis and is necessary for steroidogenesis and biogenesis of iron-sulfur clusters.	Iron	135-139	ferredoxin reductase	Mus musculus	22-26
28747430-2	2017	To determine the biological function of FDXR, we generated a Fdxr-deficient mouse model and found that loss of Fdxr led to embryonic lethality potentially due to iron overload in developing embryos.	Iron	162-166	ferredoxin reductase	Mus musculus	40-44
28747430-2	2017	To determine the biological function of FDXR, we generated a Fdxr-deficient mouse model and found that loss of Fdxr led to embryonic lethality potentially due to iron overload in developing embryos.	Iron	162-166	ferredoxin reductase	Mus musculus	111-115
28747430-4	2017	We also found that FDXR was necessary for mitochondrial iron homeostasis and proper expression of several master regulators of iron metabolism, including iron regulatory protein 2 (IRP2).	Iron	56-60	ferredoxin reductase	Mus musculus	19-23
28747430-4	2017	We also found that FDXR was necessary for mitochondrial iron homeostasis and proper expression of several master regulators of iron metabolism, including iron regulatory protein 2 (IRP2).	Iron	127-131	ferredoxin reductase	Mus musculus	19-23
27358414-10	2016	Duodenal mucosal tumor necrosis factor alpha (TNFA), interleukin (IL) 1beta, and IL6 relative gene expression was upregulated by 36%, 28%, and 45%, respectively, in H-Fe pigs (P &lt; 0.05), but not in L-Fe pigs, compared with A-Fe pigs.	Iron	167-169	tumor necrosis factor	Sus scrofa	46-50
27358414-10	2016	Duodenal mucosal tumor necrosis factor alpha (TNFA), interleukin (IL) 1beta, and IL6 relative gene expression was upregulated by 36%, 28%, and 45%, respectively, in H-Fe pigs (P &lt; 0.05), but not in L-Fe pigs, compared with A-Fe pigs.	Iron	167-169	interleukin 6	Sus scrofa	81-84
27358414-10	2016	Duodenal mucosal tumor necrosis factor alpha (TNFA), interleukin (IL) 1beta, and IL6 relative gene expression was upregulated by 36%, 28%, and 45%, respectively, in H-Fe pigs (P &lt; 0.05), but not in L-Fe pigs, compared with A-Fe pigs.	Iron	203-205	interleukin 6	Sus scrofa	81-84
28747430-6	2017	Moreover, we found that the signal from FDXR to iron homeostasis and the p53 pathway was transduced by ferredoxin 2, a substrate of FDXR.	Iron	48-52	ferredoxin reductase	Mus musculus	40-44
28747430-6	2017	Moreover, we found that the signal from FDXR to iron homeostasis and the p53 pathway was transduced by ferredoxin 2, a substrate of FDXR.	Iron	48-52	ferredoxin reductase	Mus musculus	132-136
29122540-10	2018	At the same time, with iron intervention, the concentrations of serum SOD decreased but MDA increased; the mRNA expression of osteocalcin and osteoprotegerin (OPG) decreased, whereas that of receptor activator of nuclear factor kappa B ligand (RANKL) and IL-6 increased significantly.	Iron	23-27	TNF superfamily member 11	Rattus norvegicus	191-242
28335084-1	2017	Hereditary Hemochromatosis (HH) is a genetically heterogeneous disorder caused by mutations in at least five different genes (HFE, HJV, TFR2, SLC40A1, HAMP) involved in the production or activity of the liver hormone hepcidin, a key regulator of systemic iron homeostasis.	Iron	255-259	homeostatic iron regulator	Homo sapiens	126-129
27002602-8	2016	Docking indicated that the N-containing rings of OME possibly could interact with the iron atom of the heme for S-OME in CYP17A1 and S- and R-OME in CYP21A2.	Iron	86-90	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	121-128
29122540-10	2018	At the same time, with iron intervention, the concentrations of serum SOD decreased but MDA increased; the mRNA expression of osteocalcin and osteoprotegerin (OPG) decreased, whereas that of receptor activator of nuclear factor kappa B ligand (RANKL) and IL-6 increased significantly.	Iron	23-27	TNF superfamily member 11	Rattus norvegicus	244-249
27428732-5	2016	Our results demonstrated that HFe rats had increased plasma non-transferrin bound iron (NTBI), malondialdehyde (MDA), cardiac iron and MDA levels and cardiac mitochondrial dysfunction, leading to LV dysfunction.	Iron	82-86	homeostatic iron regulator	Rattus norvegicus	30-33
29225034-4	2018	Overexpression or knockout of MAGE-F1 altered Fe-S incorporation into MMS19-dependent DNA repair enzymes, DNA repair capacity, sensitivity to DNA-damaging agents, and iron homeostasis.	Iron	167-171	MAGE family member F1	Homo sapiens	30-37
27428732-5	2016	Our results demonstrated that HFe rats had increased plasma non-transferrin bound iron (NTBI), malondialdehyde (MDA), cardiac iron and MDA levels and cardiac mitochondrial dysfunction, leading to LV dysfunction.	Iron	126-130	homeostatic iron regulator	Rattus norvegicus	30-33
28551638-2	2017	While the function in iron transport of the TFRC is well documented the functional importance of MTf is not yet fully understood.	Iron	22-26	transferrin receptor	Homo sapiens	44-48
29241202-0	2018	Ghrelin is Negatively Correlated with Iron in the Serum in Human and Mice.	Iron	38-42	ghrelin	Mus musculus	0-7
29241202-1	2018	BACKGROUND/AIMS: The studies in the patients with iron deficiency anemia (IDA) implied the existence of the association of ghrelin with iron or hepcidin levels in the plasma under the pathophysiological conditions.	Iron	50-54	ghrelin	Mus musculus	123-130
28485214-1	2017	The flavor deterioration of mayonnaise is induced by iron, which is released from egg yolk phosvitin under acidic conditions and promotes lipid oxidation.	Iron	53-57	casein kinase 2 beta	Homo sapiens	91-100
28338217-1	2018	The significant positive correlation between ghrelin and iron and hepcidin levels in the plasma of children with iron deficiency anemia prompted us to hypothesize that ghrelin may affect iron metabolism.	Iron	57-61	appetite-regulating hormone	Capra hircus	168-175
28387022-4	2017	Physiological iron balance is tightly controlled at the cellular and systemic level by iron regulatory proteins (IRP1, IRP2) and the iron regulatory hormone hepcidin, respectively.	Iron	14-18	aconitase 1	Homo sapiens	113-117
28338217-1	2018	The significant positive correlation between ghrelin and iron and hepcidin levels in the plasma of children with iron deficiency anemia prompted us to hypothesize that ghrelin may affect iron metabolism.	Iron	113-117	appetite-regulating hormone	Capra hircus	45-52
28338217-1	2018	The significant positive correlation between ghrelin and iron and hepcidin levels in the plasma of children with iron deficiency anemia prompted us to hypothesize that ghrelin may affect iron metabolism.	Iron	113-117	appetite-regulating hormone	Capra hircus	168-175
29590662-0	2018	Urinary Iron Excretion is Associated with Urinary Full-Length Megalin and Renal Oxidative Stress in Chronic Kidney Disease.	Iron	8-12	LDL receptor related protein 2	Homo sapiens	62-69
27834478-7	2017	Impaired iron export is related to inflammation and metabolic derangements that appear to impact on iron regulators, such as hepcidin, ferroportin and to a lesser degree on transferrin receptor, ferritin or copper.	Iron	9-13	transferrin receptor	Homo sapiens	173-193
29590662-1	2018	BACKGROUND/AIMS: Megalin mediates the uptake of glomerular-filtered iron in the proximal tubules.	Iron	68-72	LDL receptor related protein 2	Homo sapiens	17-24
29590662-3	2018	In the present study, we investigated the association between urinary iron and C-megalin in chronic kidney disease (CKD) patients, and the possible harmful effect of iron in renal tubules.	Iron	70-74	LDL receptor related protein 2	Homo sapiens	81-88
29590662-5	2018	RESULTS: Although both urinary C-megalin and urinary total protein levels were correlated with urinary iron (C-megalin: rho = 0.574, p &lt;0.001; total protein: rho = 0.500, p &lt;0.001, respectively), urinary C-megalin alone emerged as an independent factor positively associated with urinary iron (beta = 0.520, p &lt;0.001) (R2 = 0.75, p &lt;0.001).	Iron	103-107	LDL receptor related protein 2	Homo sapiens	33-40
28538180-0	2017	Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.	Iron	20-24	zinc finger CCCH type containing 12A	Mus musculus	0-9
28538180-0	2017	Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.	Iron	20-24	transferrin receptor	Mus musculus	60-82
28538180-2	2017	The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease.	Iron	16-20	transferrin receptor	Mus musculus	39-61
28538180-2	2017	The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease.	Iron	16-20	transferrin receptor	Mus musculus	63-67
28538180-3	2017	Here, we show that the endonuclease Regnase-1 is critical for the degradation of mRNAs involved in iron metabolism in vivo.	Iron	99-103	zinc finger CCCH type containing 12A	Mus musculus	36-45
29590662-5	2018	RESULTS: Although both urinary C-megalin and urinary total protein levels were correlated with urinary iron (C-megalin: rho = 0.574, p &lt;0.001; total protein: rho = 0.500, p &lt;0.001, respectively), urinary C-megalin alone emerged as an independent factor positively associated with urinary iron (beta = 0.520, p &lt;0.001) (R2 = 0.75, p &lt;0.001).	Iron	103-107	LDL receptor related protein 2	Homo sapiens	111-118
28538180-7	2017	We reveal that duodenal Regnase-1 controls the expression of PHD3, which impairs duodenal iron uptake via HIF2alpha suppression.	Iron	90-94	zinc finger CCCH type containing 12A	Mus musculus	24-33
28538180-9	2017	Collectively, these results demonstrate that Regnase-1-mediated regulation of iron-related transcripts is essential for the maintenance of iron homeostasis.	Iron	78-82	zinc finger CCCH type containing 12A	Mus musculus	45-54
29590662-5	2018	RESULTS: Although both urinary C-megalin and urinary total protein levels were correlated with urinary iron (C-megalin: rho = 0.574, p &lt;0.001; total protein: rho = 0.500, p &lt;0.001, respectively), urinary C-megalin alone emerged as an independent factor positively associated with urinary iron (beta = 0.520, p &lt;0.001) (R2 = 0.75, p &lt;0.001).	Iron	103-107	LDL receptor related protein 2	Homo sapiens	111-118
28538180-9	2017	Collectively, these results demonstrate that Regnase-1-mediated regulation of iron-related transcripts is essential for the maintenance of iron homeostasis.	Iron	139-143	zinc finger CCCH type containing 12A	Mus musculus	45-54
29590662-6	2018	Furthermore, urinary iron was significantly and positively associated with urinary 8-hydroxydeoxyguanosine, an oxidative stress marker, while no association with other markers of renal tubular injury, i.e., beta2-microglobulin and N-acetyl-beta-D-glucosaminidase, was noted.	Iron	21-25	O-GlcNAcase	Homo sapiens	231-262
29590662-7	2018	CONCLUSIONS: Our findings suggest that renal iron handling may be associated with megalin-mediated endo-lysosomal metabolic load in PTECs of residual nephrons and oxidative stress in renal tubules.	Iron	45-49	LDL receptor related protein 2	Homo sapiens	82-89
29317052-7	2018	In addition, it is demonstrated that iron is able to amplify Wnt signaling in tumors with Apc mutation, a critical mutation in the development of colorectal cancer.	Iron	37-41	APC regulator of WNT signaling pathway	Homo sapiens	90-93
28580110-4	2017	Upon successful intercalation of the FeS layer, the superconducting critical temperature Tc of mackinawite is enhanced from 5 K to 8 K for the (Li1-x Fe x OH) delta+ intercalate.	Iron	37-40	transglutaminase 1	Homo sapiens	144-147
29467999-2	2018	We investigated whether coinheritance of HFE H63D or C282Y gene mutations in patients with BTM contributes to the phenotypic variation of iron overload complications and assessed the correlation of cardiac and hepatic hemosiderosis with plasma ferritin levels.	Iron	138-142	homeostatic iron regulator	Homo sapiens	41-44
27717800-0	2017	Effect of iron deficiency anemia and iron supplementation on HbA1c levels - Implications for diagnosis of prediabetes and diabetes mellitus in Asian Indians.	Iron	10-14	hemoglobin subunit alpha 1	Homo sapiens	61-65
27561698-1	2017	BACKGROUND: Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron absorption.HFE gene mutations C282Y and H63D are responsible for the majority of hereditary hemochromatosis cases.	Iron	56-60	homeostatic iron regulator	Homo sapiens	115-118
27561698-1	2017	BACKGROUND: Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron absorption.HFE gene mutations C282Y and H63D are responsible for the majority of hereditary hemochromatosis cases.	Iron	99-103	homeostatic iron regulator	Homo sapiens	115-118
29877248-7	2018	Target genes included those involved in mitochondrial iron metabolism or heme biosynthesis, such as ABCB7 and PPOX, suggesting a role in the abnormal erythropoiesis associated with increased ring sideroblasts.	Iron	54-58	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	100-105
27561698-2	2017	METHODS: We tried to look at the effect of HFE mutations on the iron status.	Iron	64-68	homeostatic iron regulator	Homo sapiens	43-46
29237257-6	2017	This phenotype is recapitulated by loss of Fer1HCH in the intestine, indicating that reduced levels of systemic iron enhances crystal cell differentiation.	Iron	112-116	Ferritin 1 heavy chain homologue	Drosophila melanogaster	43-50
28150420-0	2017	A homozygous splice variant in AP4S1 mimicking neurodegeneration with brain iron accumulation.	Iron	76-80	adaptor related protein complex 4 subunit sigma 1	Homo sapiens	31-36
29312931-2	2017	The results showed that three small proteins, including histidine biosynthesis protein (HisIE), iron donor protein (CyaY) and hypothetical protein_65aa, have a higher ability to adsorb gold ions because of the negatively charged domains or metal binding sites.	Iron	96-100	frataxin	Homo sapiens	116-120
28459879-5	2017	Tf:Fe starvation results in up-regulation and redistribution of TfR to the plasma membrane suggesting a saturable mechanism for flagellar pocket retention.	Iron	3-5	transferrin receptor	Homo sapiens	64-67
28358192-0	2017	Iron Binding Properties of Recombinant Class A Protein Disulfide Isomerase from Arabidopsis thaliana.	Iron	0-4	protein disulfide isomerase	Arabidopsis thaliana	47-74
28358192-9	2017	It is therefore proposed that the unexpected ability of rAtPDI-A to accommodate an Fe-S cluster is due to its very unique CKHC motif, which is conserved in all higher-plant class A PDIs, differentiating them from all other members of the PDI family.	Iron	83-87	protein disulfide isomerase	Arabidopsis thaliana	59-62
29200434-0	2017	Iron-induced oligomerization of human FXN81-210 and bacterial CyaY frataxin and the effect of iron chelators.	Iron	0-4	frataxin	Homo sapiens	62-66
29200434-0	2017	Iron-induced oligomerization of human FXN81-210 and bacterial CyaY frataxin and the effect of iron chelators.	Iron	0-4	frataxin	Homo sapiens	67-75
29200434-6	2017	To explore the mechanisms of stabilization of short variant frataxin oligomers we compare here the effect of iron on the oligomerization of CyaY and FXN81-210.	Iron	109-113	frataxin	Homo sapiens	140-144
29200434-7	2017	Using dynamic light scattering, small-angle X-ray scattering, electron microscopy (EM) and cross linking mass spectrometry (MS), we show that at aerobic conditions in the presence of iron both FXN81-210 and CyaY form oligomers.	Iron	183-187	frataxin	Homo sapiens	207-211
27121697-11	2017	CONCLUSION: Iron chelation by oral deferiprone has a renoprotective effect in DN rats by relieving oxidative stress, inflammation, and fibrosis, which is related to the cytokines NF-kappaB, MCP-1, MMP-9, TIMP-1, COX-2, and nitrotyrosine.	Iron	12-16	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	212-217
29200434-9	2017	The higher stability of CyaY oligomers can be explained by a higher number of acidic residues at the interface between monomers, which may result in a more stable iron binding.	Iron	163-167	frataxin	Homo sapiens	24-28
28942941-7	2017	Low-serum iron was associated with a higher left ventricular end-diastolic dimension and left ventricular end-systolic dimension z-score by echocardiography ((beta -2.58, 95% confidence interval [CI] -4.76, -0.40, p = 0.02) and (beta -2.43, 95% CI -4.70, -0.17, p = 0.04)), respectively.	Iron	10-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	159-166
28157766-0	2017	Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers.	Iron	110-114	angiotensin II receptor type 1	Homo sapiens	55-59
28157766-1	2017	OBJECTIVE: This study aimed to analyze the interaction of Angiotensin II type 1 receptor (AT1R) gene polymorphism and occupational noise on the occurrence of essential hypertension (EH) in steel and iron enterprise men workers.	Iron	199-203	angiotensin II receptor type 1	Homo sapiens	90-94
28942941-7	2017	Low-serum iron was associated with a higher left ventricular end-diastolic dimension and left ventricular end-systolic dimension z-score by echocardiography ((beta -2.58, 95% confidence interval [CI] -4.76, -0.40, p = 0.02) and (beta -2.43, 95% CI -4.70, -0.17, p = 0.04)), respectively.	Iron	10-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	229-236
28358914-1	2017	Human hemochromatosis protein (HFE) is involved in iron metabolism.	Iron	51-55	homeostatic iron regulator	Homo sapiens	31-34
29070551-7	2017	Cellular iron concentrations are modulated by the iron regulatory proteins (IRPs) IRP1 and IRP2.	Iron	9-13	aconitase 1	Homo sapiens	82-86
29070551-7	2017	Cellular iron concentrations are modulated by the iron regulatory proteins (IRPs) IRP1 and IRP2.	Iron	50-54	aconitase 1	Homo sapiens	82-86
29070555-7	2017	HFE C282Y homozygosity had the most marked independent association with elevated iron stores in nonpregnant and nonbreastfeeding women and in pregnant or breastfeeding women (OR &gt;49.0; P &lt; 0.001), but African American ethnicity was also associated with increased iron stores in both groups of women (OR &gt;2.0; P &lt; 0.001).	Iron	81-85	homeostatic iron regulator	Homo sapiens	0-3
28189691-3	2017	In this study, to develop a novel molecular-targeted therapy against TFR1 to modulate iron metabolism, we initially determined the expression pattern of several iron-related genes along with TFR1 and found that ATLL cells presented characteristic of an iron-deficiency state such as high expression of iron-regulatory protein 2 (IRP2) and low expression of its E3 ubiquitin-ligase, FBXL5.	Iron	86-90	transferrin receptor	Homo sapiens	69-73
28189691-3	2017	In this study, to develop a novel molecular-targeted therapy against TFR1 to modulate iron metabolism, we initially determined the expression pattern of several iron-related genes along with TFR1 and found that ATLL cells presented characteristic of an iron-deficiency state such as high expression of iron-regulatory protein 2 (IRP2) and low expression of its E3 ubiquitin-ligase, FBXL5.	Iron	161-165	transferrin receptor	Homo sapiens	69-73
29070555-7	2017	HFE C282Y homozygosity had the most marked independent association with elevated iron stores in nonpregnant and nonbreastfeeding women and in pregnant or breastfeeding women (OR &gt;49.0; P &lt; 0.001), but African American ethnicity was also associated with increased iron stores in both groups of women (OR &gt;2.0; P &lt; 0.001).	Iron	269-273	homeostatic iron regulator	Homo sapiens	0-3
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	DNA polymerase iota	Homo sapiens	131-135
29070555-8	2017	Asian American ethnicity (OR: 1.8; P = 0.001) and HFE C282Y heterozygosity (OR: 1.9; P = 0.003) were associated with increased iron stores in nonpregnant and nonbreastfeeding women.Conclusions: Both ID and elevated iron stores are present in women of reproductive age and are influenced by ethnicity and HFE C282Y.	Iron	127-131	homeostatic iron regulator	Homo sapiens	50-53
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	DNA polymerase iota	Homo sapiens	136-140
29070555-8	2017	Asian American ethnicity (OR: 1.8; P = 0.001) and HFE C282Y heterozygosity (OR: 1.9; P = 0.003) were associated with increased iron stores in nonpregnant and nonbreastfeeding women.Conclusions: Both ID and elevated iron stores are present in women of reproductive age and are influenced by ethnicity and HFE C282Y.	Iron	127-131	homeostatic iron regulator	Homo sapiens	304-307
29070555-8	2017	Asian American ethnicity (OR: 1.8; P = 0.001) and HFE C282Y heterozygosity (OR: 1.9; P = 0.003) were associated with increased iron stores in nonpregnant and nonbreastfeeding women.Conclusions: Both ID and elevated iron stores are present in women of reproductive age and are influenced by ethnicity and HFE C282Y.	Iron	215-219	homeostatic iron regulator	Homo sapiens	50-53
28151426-3	2017	Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis.	Iron	18-22	transferrin receptor	Mus musculus	34-56
28151426-3	2017	Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis.	Iron	18-22	transferrin receptor	Mus musculus	58-62
29390526-3	2017	In this study, we analyzed genetic variation sites in BMP2 (rs235756, rs235768) and BMP4 (rs4901474) to get more evidence linking iron metabolism to hypertension risk in the Finnish population.The study included 321 hypertensive cases and 463 controls from the Tampere Adult Population Cardiovascular Risk study cohort.	Iron	130-134	bone morphogenetic protein 4	Homo sapiens	84-88
28151426-3	2017	Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis.	Iron	90-94	transferrin receptor	Mus musculus	34-56
28151426-3	2017	Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis.	Iron	90-94	transferrin receptor	Mus musculus	58-62
28151426-7	2017	These findings strongly suggest that overexpressed TfR1 may play a regulatory role contributing to iron overload and anemia in beta-thalassemic mice.	Iron	99-103	transferrin receptor	Mus musculus	51-55
28151426-10	2017	Our data demonstrate for the first time that TfR1+/- haploinsufficiency reverses iron overload specifically in beta-thalassemic erythroid precursors.	Iron	81-85	transferrin receptor	Mus musculus	45-49
28151426-11	2017	Taken together, decreasing TfR1 expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin, leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice.	Iron	282-286	transferrin receptor	Mus musculus	27-31
28151426-11	2017	Taken together, decreasing TfR1 expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin, leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice.	Iron	337-341	transferrin receptor	Mus musculus	27-31
27188213-11	2016	The iron regulon, as reported by Fet3p levels, was not expressed during post-exponential conditions; Fet3p was maximally expressed in exponentially growing cells.	Iron	4-8	ferroxidase FET3	Saccharomyces cerevisiae S288C	33-38
28993186-11	2017	These events paralleled the increased expression of ferritins and transferrin and a decrease in the expression of TFR-1 in iron-fed rats with aging, thereby maintaining iron homeostasis in the retina.	Iron	123-127	transferrin receptor	Rattus norvegicus	114-119
27401861-2	2016	Atx1p plays an important role in the intracellular copper transport as a copper chaperone transferring copper from the transporters to Ccc2p for its subsequent insertion into Fet3p, which is required for high affinity iron transport.	Iron	218-222	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	135-140
27401861-2	2016	Atx1p plays an important role in the intracellular copper transport as a copper chaperone transferring copper from the transporters to Ccc2p for its subsequent insertion into Fet3p, which is required for high affinity iron transport.	Iron	218-222	ferroxidase FET3	Saccharomyces cerevisiae S288C	175-180
27753142-8	2017	CONCLUSIONS: An iron metabolism gene panel provided a molecular diagnosis in six patients with non-HFE iron overload and is suitable for diagnostic purposes in exceptional cases in specialized clinics.	Iron	16-20	homeostatic iron regulator	Homo sapiens	99-102
28993186-11	2017	These events paralleled the increased expression of ferritins and transferrin and a decrease in the expression of TFR-1 in iron-fed rats with aging, thereby maintaining iron homeostasis in the retina.	Iron	169-173	transferrin receptor	Rattus norvegicus	114-119
27825814-4	2017	RESULTS: GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects.	Iron	158-162	T-box transcription factor 1	Homo sapiens	15-18
27825814-6	2017	Furthermore, both GPCA-/TGA/TMA/RAS and Abs-/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects.	Iron	105-109	T-box transcription factor 1	Homo sapiens	24-27
27405729-3	2016	Following the observation that altered Fe-S biosynthesis is correlated with a high sensitivity to hydroxyurea (HU), a potent DNA replication blocking agent, we identified that oxidative stress response pathway under the control of the main regulator Yap1 attenuates HU deleterious effects, as it significantly increases resistance to HU, Fe-S biosynthesis and DNA replication kinetics in the presence of HU.	Iron	39-43	Yes1 associated transcriptional regulator	Homo sapiens	250-254
29138470-1	2017	Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive.	Iron	77-81	lipocalin 2	Mus musculus	0-42
27405729-3	2016	Following the observation that altered Fe-S biosynthesis is correlated with a high sensitivity to hydroxyurea (HU), a potent DNA replication blocking agent, we identified that oxidative stress response pathway under the control of the main regulator Yap1 attenuates HU deleterious effects, as it significantly increases resistance to HU, Fe-S biosynthesis and DNA replication kinetics in the presence of HU.	Iron	338-342	Yes1 associated transcriptional regulator	Homo sapiens	250-254
27405729-4	2016	Yap1 effect is mediated at least in part through up-regulation of two highly conserved genes controlling cytosolic Fe-S biosynthesis and oxidative stress, Dre2 and Tah18.	Iron	115-119	Yes1 associated transcriptional regulator	Homo sapiens	0-4
27825814-6	2017	Furthermore, both GPCA-/TGA/TMA/RAS and Abs-/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects.	Iron	169-173	T-box transcription factor 1	Homo sapiens	24-27
29138470-1	2017	Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive.	Iron	77-81	lipocalin 2	Mus musculus	44-48
29442300-1	2017	INTRODUCTION: HFE-associated haemochromatosis, the most common monogenic disorder amongst populations of northern European ancestry, is characterised by iron overload.	Iron	153-157	homeostatic iron regulator	Homo sapiens	14-17
29138470-1	2017	Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive.	Iron	77-81	lipocalin 2	Mus musculus	50-61
29138470-1	2017	Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive.	Iron	77-81	lipocalin 2	Mus musculus	65-69
27221532-3	2016	The HFE gene also affects the activity of hepcidin, a hormone which acts as a negative regulator of iron metabolism.	Iron	100-104	homeostatic iron regulator	Homo sapiens	4-7
29151315-6	2017	Iron replacement therapy can decrease HbA1c in anemic patients with IDA and T2DM.	Iron	0-4	hemoglobin subunit alpha 1	Homo sapiens	38-42
27250827-11	2016	In conclusion, downregulation of ferroportin-1 and ceruloplasmin caused by hepcidin enhanced iron-dependent oxidative damage and may be the potential mechanism of SAH.	Iron	93-97	ceruloplasmin	Rattus norvegicus	51-64
28955733-6	2017	METHODS: We have examined in K562 cells, which can be induced to undergo erythroid differentiation by PP IX and hemin, the effects of PP IX on the expression of PAP7 and other proteins involved in cellular iron metabolism, transferrin receptor 1 (TfR1), DMT1, ferritin heavy chain (FTH), c-Myc and C/EBPalpha by western blot and quantitative real time PCR analyses.	Iron	206-210	acyl-CoA binding domain containing 3	Homo sapiens	161-165
28955733-10	2017	GENERAL SIGNIFICANCE: These results suggest that exogenous PP IX disrupts iron metabolism by decreasing the protein expression levels of PAP7, DMT1 and C/EBPalpha.	Iron	74-78	acyl-CoA binding domain containing 3	Homo sapiens	137-141
27856053-2	2017	The characterization by XRD, SEM-EDX and BET-N2 adsorption demonstrated that Fe, Cu/Fe and Mn/Fe nano particles were successfully loaded onto NaY zeolite and exhibited larger BET surface area compared to nano-Fe0 (nZVI).	Iron	84-86	delta/notch like EGF repeat containing	Homo sapiens	41-44
27856053-2	2017	The characterization by XRD, SEM-EDX and BET-N2 adsorption demonstrated that Fe, Cu/Fe and Mn/Fe nano particles were successfully loaded onto NaY zeolite and exhibited larger BET surface area compared to nano-Fe0 (nZVI).	Iron	84-86	delta/notch like EGF repeat containing	Homo sapiens	175-178
27856053-2	2017	The characterization by XRD, SEM-EDX and BET-N2 adsorption demonstrated that Fe, Cu/Fe and Mn/Fe nano particles were successfully loaded onto NaY zeolite and exhibited larger BET surface area compared to nano-Fe0 (nZVI).	Iron	84-86	delta/notch like EGF repeat containing	Homo sapiens	41-44
27856053-2	2017	The characterization by XRD, SEM-EDX and BET-N2 adsorption demonstrated that Fe, Cu/Fe and Mn/Fe nano particles were successfully loaded onto NaY zeolite and exhibited larger BET surface area compared to nano-Fe0 (nZVI).	Iron	84-86	delta/notch like EGF repeat containing	Homo sapiens	175-178
27343351-0	2016	Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.	Iron	25-29	frataxin	Drosophila melanogaster	8-16
27343351-4	2016	We show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2).	Iron	66-70	frataxin	Drosophila melanogaster	21-37
27343351-7	2016	Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA.	Iron	29-33	myocyte enhancer factor 2A	Homo sapiens	52-56
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	MYD88 innate immune signal transduction adaptor	Homo sapiens	172-205
29291011-2	2017	We conducted a thorough, large-scale investigation of the expression and prognostic significance of the primary iron uptake protein, transferrin receptor 1 (TfR1/CD71/TFRC), in RCC patients.	Iron	112-116	transferrin receptor	Homo sapiens	157-161
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	CD74 molecule	Homo sapiens	215-219
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	high mobility group box 1	Homo sapiens	254-279
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	high mobility group box 1	Homo sapiens	281-286
28924039-12	2017	Moreover, iron-loaded transferrin blocked MT2-mediated Tfr2 cleavage, providing further insights into the mechanism of Tfr2"s regulation by transferrin.	Iron	10-14	transmembrane serine protease 6	Mus musculus	42-45
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	transferrin receptor	Homo sapiens	302-306
28243203-3	2017	We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion.	Iron	121-125	transferrin receptor	Rattus norvegicus	48-52
27462458-8	2016	Our results suggest that DMT1 release from the plasma membrane into EVs may represent a novel mechanism for the maintenance of iron homeostasis, which may also be important for the regulation of other membrane proteins.	Iron	127-131	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	25-29
27335591-0	2016	Frequency of Hereditary Hemochromatosis (HFE) Gene Mutations in Egyptian Beta Thalassemia Patients and its Relation to Iron Overload.	Iron	119-123	homeostatic iron regulator	Homo sapiens	41-44
27335591-1	2016	AIM: This study aimed to detect the most common HFE gene mutations (C282Y, H63D, and S56C) in Egyptian beta thalassemia major patients and its relation to their iron status.	Iron	161-165	homeostatic iron regulator	Homo sapiens	48-51
28243203-3	2017	We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion.	Iron	230-234	transferrin receptor	Rattus norvegicus	48-52
28243203-3	2017	We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion.	Iron	230-234	transferrin receptor	Rattus norvegicus	48-52
27582023-3	2017	AIM: To determine cystatin C levels in 53 children and adolescents with SCD compared to 40 age- and sex-matched healthy controls and assess its relation to markers of hemolysis, iron overload, sickle vasculopathy, and carotid intima-media thickness (CIMT).	Iron	178-182	cystatin C	Homo sapiens	18-28
28243203-7	2017	These findings suggest that the nifedipine-induced increase in cell iron may mainly be due to the corresponding increase in TfR1 and DMT1 expression and also imply that the effects of nifedipine on iron transport in proximal tubule cells can not explain the increase in urinary iron excretion.	Iron	68-72	transferrin receptor	Rattus norvegicus	124-128
27193999-0	2016	The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation.	Iron	14-18	ARM repeat superfamily protein	Arabidopsis thaliana	46-51
27193999-4	2016	Through a forward genetic screening of Arabidopsis mutants showing DNA hypermethylation at the EPF2 promoter region, we identified the conserved iron-sulfur cluster assembly protein MET18.	Iron	145-149	ARM repeat superfamily protein	Arabidopsis thaliana	182-187
27193999-7	2016	ROS1 activity was reduced in the met18 mutant plants and point mutation in the conserved Fe-S cluster binding motif of ROS1 disrupted its biological function.	Iron	89-93	ARM repeat superfamily protein	Arabidopsis thaliana	33-38
29125828-3	2017	Frataxin is a mitochondrial protein involved in iron-sulfur cluster synthesis, and many FRDA phenotypes result from deficiencies in cellular metabolism due to lowered expression of FXN Presently, there is no effective treatment for FRDA, and biomarkers to measure therapeutic trial outcomes and/or to gauge disease progression are lacking.	Iron	48-52	frataxin	Homo sapiens	0-8
27621921-2	2016	Polymorphisms in the hemochromatosis (HFE) genes are responsible for iron accumulation in most cases of hemochromatosis, and may play a role in HCV infection.	Iron	69-73	homeostatic iron regulator	Homo sapiens	38-41
28178997-12	2017	CONCLUSIONS: SCI may cause intracranial iron overload through the NOS-iron-responsive element/IRP pathway, resulting in central pain mediated by the oxidative stress response.	Iron	40-44	caspase 3	Rattus norvegicus	94-97
28178997-12	2017	CONCLUSIONS: SCI may cause intracranial iron overload through the NOS-iron-responsive element/IRP pathway, resulting in central pain mediated by the oxidative stress response.	Iron	70-74	caspase 3	Rattus norvegicus	94-97
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	Iron	71-75	Fit2p	Saccharomyces cerevisiae S288C	96-100
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	72-76	transferrin receptor	Homo sapiens	197-217
28057442-0	2017	Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.	Iron	0-4	solute carrier family 39 (zinc transporter), member 14	Mus musculus	24-29
28057442-0	2017	Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.	Iron	79-83	solute carrier family 39 (zinc transporter), member 14	Mus musculus	24-29
28057442-11	2017	These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation.	Iron	96-100	solute carrier family 39 (zinc transporter), member 14	Mus musculus	34-39
27152948-3	2016	METHODS: In the mouse model of transient middle cerebral artery occlusion (tMCAO), LCN2 expression in the brain was analyzed by immunohistochemistry and correlated to cellular nonheme iron deposition up to 42 days after tMCAO.	Iron	184-188	lipocalin 2	Mus musculus	83-87
27015669-9	2016	Finally, gene silencing using sestrin-2 siRNA and the ectopic expression of recombinant adenoviral sestrin-2 indicated that sestrin-2 induction by eupatilin was required for autophagy-mediated cytoprotection against AA + iron.	Iron	221-225	sestrin 2	Homo sapiens	99-108
28057442-11	2017	These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation.	Iron	138-142	solute carrier family 39 (zinc transporter), member 14	Mus musculus	34-39
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	72-76	transferrin receptor	Homo sapiens	219-222
27015669-9	2016	Finally, gene silencing using sestrin-2 siRNA and the ectopic expression of recombinant adenoviral sestrin-2 indicated that sestrin-2 induction by eupatilin was required for autophagy-mediated cytoprotection against AA + iron.	Iron	221-225	sestrin 2	Homo sapiens	99-108
27015669-10	2016	Our results suggest that eupatilin activates sestrin-2-dependent autophagy, thereby preventing oxidative stress induced by AA + iron.	Iron	128-132	sestrin 2	Homo sapiens	45-54
29061112-0	2017	Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.	Iron	30-34	Wnt family member 2	Homo sapiens	0-23
29061112-0	2017	Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.	Iron	30-34	Wnt family member 2	Homo sapiens	25-28
26827808-0	2016	Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1.	Iron	0-4	CREB regulated transcription coactivator 1	Mus musculus	26-32
26827808-3	2016	Herein, we test whether iron depletion induced by cell incubation with the iron chelator, deferoxamine (DFO), mediates its effects on cell growth through mTORC1-directed signalling and protein synthesis.	Iron	24-28	CREB regulated transcription coactivator 1	Mus musculus	154-160
29061112-2	2017	Iron homeostasis is maintained by iron regulatory proteins (IRP1 and IRP2) and the iron-responsive element (IRE) signaling pathway.	Iron	0-4	aconitase 1	Homo sapiens	60-64
26827808-3	2016	Herein, we test whether iron depletion induced by cell incubation with the iron chelator, deferoxamine (DFO), mediates its effects on cell growth through mTORC1-directed signalling and protein synthesis.	Iron	75-79	CREB regulated transcription coactivator 1	Mus musculus	154-160
29061112-2	2017	Iron homeostasis is maintained by iron regulatory proteins (IRP1 and IRP2) and the iron-responsive element (IRE) signaling pathway.	Iron	34-38	aconitase 1	Homo sapiens	60-64
26827808-8	2016	The increase in REDD1 abundance was rapidly reversed upon iron repletion of cells but was also attenuated by inhibitors of gene transcription, protein phosphatase 2A (PP2A) and by REDD1 siRNA--strategies that also antagonised the loss in mTORC1 signalling associated with iron depletion.	Iron	58-62	CREB regulated transcription coactivator 1	Mus musculus	238-244
26827808-9	2016	Our findings implicate REDD1 and PP2A as crucial regulators of mTORC1 activity in iron-depleted cells and indicate that their modulation may help mitigate atrophy of the intestinal mucosa that may occur in response to iron deficiency.	Iron	82-86	CREB regulated transcription coactivator 1	Mus musculus	63-69
26827808-9	2016	Our findings implicate REDD1 and PP2A as crucial regulators of mTORC1 activity in iron-depleted cells and indicate that their modulation may help mitigate atrophy of the intestinal mucosa that may occur in response to iron deficiency.	Iron	218-222	CREB regulated transcription coactivator 1	Mus musculus	63-69
28965846-0	2017	FDXR Mutations Cause Sensorial Neuropathies and Expand the Spectrum of Mitochondrial Fe-S-Synthesis Diseases.	Iron	85-89	ferredoxin reductase	Homo sapiens	0-4
27033261-4	2016	Carriage of allelic variants of the HFE gene induces altered iron metabolism and may contribute to toxicity.	Iron	61-65	homeostatic iron regulator	Homo sapiens	36-39
28965846-6	2017	We observed deregulated iron homeostasis in FDXR mutant fibroblasts and indirect evidence of mitochondrial iron overload.	Iron	24-28	ferredoxin reductase	Homo sapiens	44-48
28744713-4	2017	The aim of the study was to investigate COP9 signalosome in Fe deficiency response of Strategy I plants.	Iron	60-62	COP9 signalosome, subunit CSN8	Arabidopsis thaliana	40-44
27017620-6	2016	sgk-1 positively regulates the expression of acs-20 and vit-2, genes encoding homologs of the mammalian FATP1/4 fatty acid transport proteins and yolk lipoproteins, respectively, to facilitate lipid uptake and translocation for storage under iron overload.	Iron	242-246	solute carrier family 27 member 1	Homo sapiens	104-109
28744713-13	2017	Correct expression of Fe deficiency-responsive genes requires an intact COP9 signalosome in Arabidopsis.	Iron	22-24	COP9 signalosome, subunit CSN8	Arabidopsis thaliana	72-76
27729173-7	2017	RESULTS: In samples that had not been exposed to hepcidin, correlations were found between the expression of genes involved in iron absorption: DMT1, Fpn1, Dcytb and HCP1.	Iron	127-131	CYCS pseudogene 51	Homo sapiens	166-170
26970172-0	2016	SF3B1-mutated myelodysplastic syndrome with ring sideroblasts harbors more severe iron overload and corresponding over-erythropoiesis.	Iron	82-86	splicing factor 3b subunit 1	Homo sapiens	0-5
28775066-3	2017	At the cellular level, iron homeostasis is dependent on the iron regulatory proteins IRP1/IRP2.	Iron	23-27	aconitase 1	Homo sapiens	85-89
26970775-7	2016	We show that Rnr2-Rnr4 relocalization by low iron requires Dun1 kinase activity and phosphorylation site Thr-380 in the Dun1 activation loop, but not the Dun1 forkhead-associated domain.	Iron	45-49	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	13-17
26970775-7	2016	We show that Rnr2-Rnr4 relocalization by low iron requires Dun1 kinase activity and phosphorylation site Thr-380 in the Dun1 activation loop, but not the Dun1 forkhead-associated domain.	Iron	45-49	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	18-22
26970775-7	2016	We show that Rnr2-Rnr4 relocalization by low iron requires Dun1 kinase activity and phosphorylation site Thr-380 in the Dun1 activation loop, but not the Dun1 forkhead-associated domain.	Iron	45-49	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	59-63
26970775-8	2016	By using different Dif1 mutant proteins, we uncover that Dun1 phosphorylates Dif1 Ser-104 and Thr-105 residues upon iron scarcity.	Iron	116-120	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	57-61
26970775-10	2016	Importantly, the Dif1-S104A/T105A mutant exhibits defects in nucleus-to-cytoplasm redistribution of Rnr2-Rnr4 by iron limitation.	Iron	113-117	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	100-104
26970775-10	2016	Importantly, the Dif1-S104A/T105A mutant exhibits defects in nucleus-to-cytoplasm redistribution of Rnr2-Rnr4 by iron limitation.	Iron	113-117	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	105-109
26970775-11	2016	Taken together, these results reveal that, in response to iron starvation, Dun1 kinase phosphorylates Dif1 to stimulate Rnr2-Rnr4 relocalization to the cytoplasm and promote RNR function.	Iron	58-62	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	75-79
28775066-3	2017	At the cellular level, iron homeostasis is dependent on the iron regulatory proteins IRP1/IRP2.	Iron	60-64	aconitase 1	Homo sapiens	85-89
26970775-11	2016	Taken together, these results reveal that, in response to iron starvation, Dun1 kinase phosphorylates Dif1 to stimulate Rnr2-Rnr4 relocalization to the cytoplasm and promote RNR function.	Iron	58-62	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	120-124
26970775-11	2016	Taken together, these results reveal that, in response to iron starvation, Dun1 kinase phosphorylates Dif1 to stimulate Rnr2-Rnr4 relocalization to the cytoplasm and promote RNR function.	Iron	58-62	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	125-129
28840425-0	2017	HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication.	Iron	69-73	homeostatic iron regulator	Homo sapiens	0-3
28840425-1	2017	In liver hepatocytes, the HFE gene regulates cellular and systemic iron homeostasis by modulating cellular iron-uptake and producing the iron-hormone hepcidin in response to systemic iron elevation.	Iron	67-71	homeostatic iron regulator	Homo sapiens	26-29
28840425-1	2017	In liver hepatocytes, the HFE gene regulates cellular and systemic iron homeostasis by modulating cellular iron-uptake and producing the iron-hormone hepcidin in response to systemic iron elevation.	Iron	107-111	homeostatic iron regulator	Homo sapiens	26-29
28840425-1	2017	In liver hepatocytes, the HFE gene regulates cellular and systemic iron homeostasis by modulating cellular iron-uptake and producing the iron-hormone hepcidin in response to systemic iron elevation.	Iron	107-111	homeostatic iron regulator	Homo sapiens	26-29
26938575-3	2016	The ground state of Fe 4O is a singlet, hexavalent iron(VI) complex (1)C2v-[Fe(VI)O2](2+)(O2)(2-), with isomers of oxidation states Fe(II), Fe(III), Fe(IV), Fe(V), and Fe(VIII) all lying slightly higher within the range of 1 eV.	Iron	20-22	cytochrome c oxidase subunit 8A	Homo sapiens	171-175
28840425-1	2017	In liver hepatocytes, the HFE gene regulates cellular and systemic iron homeostasis by modulating cellular iron-uptake and producing the iron-hormone hepcidin in response to systemic iron elevation.	Iron	107-111	homeostatic iron regulator	Homo sapiens	26-29
28876922-1	2017	Porcine myofibrillar protein (MP) was modified with glucose oxidase (GluOx)-iron that produces hydroxyl radicals then subjected to microbial transglutaminase (TGase) cross-linking in 0.6 M NaCl at 4  C. The resulting aggregation and gel formation of MP were examined.	Iron	76-80	transglutaminase 1	Homo sapiens	159-164
26589002-2	2016	The aims of this study were to investigate the FXN mRNA levels in the reticulocytes of patients with HbE-beta-thalassaemia who were treated with regular transfusions, to compare the results with those from normal controls and to evaluate the relationships of the levels of FXN mRNA with malondialdehyde (MDA) and iron parameters in these patients.	Iron	313-317	frataxin	Homo sapiens	47-50
26589002-9	2016	CONCLUSIONS: The elevation of FXN expression in the reticulocytes of these patients seems to be linked to oxidative stress and iron status.	Iron	127-131	frataxin	Homo sapiens	30-33
28768766-0	2017	A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.	Iron	62-66	aconitase 1	Homo sapiens	22-26
28768766-1	2017	Iron-regulatory protein 1 (IRP1) belongs to a family of RNA-binding proteins that modulate metazoan iron metabolism.	Iron	100-104	aconitase 1	Homo sapiens	0-25
28768766-1	2017	Iron-regulatory protein 1 (IRP1) belongs to a family of RNA-binding proteins that modulate metazoan iron metabolism.	Iron	100-104	aconitase 1	Homo sapiens	27-31
25981669-4	2016	RESULTS: Timd2-expressing cells, but not control cells, showed a large increase in both R2 and R1 in vitro following incubation with iron-loaded and manganese-loaded ferritin, respectively.	Iron	133-137	T cell immunoglobulin and mucin domain containing 2	Mus musculus	9-14
28768766-2	2017	Multiple mechanisms are employed to control the action of IRP1 in dictating changes in the uptake and metabolic fate of iron.	Iron	120-124	aconitase 1	Homo sapiens	58-62
25981669-6	2016	Timd2-expressing xenografts in vivo showed much smaller changes in R2 following injection of iron-loaded ferritin than the same cells incubated in vitro with iron-loaded ferritin.	Iron	93-97	T cell immunoglobulin and mucin domain containing 2	Mus musculus	0-5
25981669-6	2016	Timd2-expressing xenografts in vivo showed much smaller changes in R2 following injection of iron-loaded ferritin than the same cells incubated in vitro with iron-loaded ferritin.	Iron	158-162	T cell immunoglobulin and mucin domain containing 2	Mus musculus	0-5
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	36-40	aconitase 1	Homo sapiens	16-20
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	36-40	aconitase 1	Homo sapiens	251-255
26921633-2	2016	This study aimed to investigate the roles of L-type calcium channels (LTCC), T-type calcium channels (TTCC) and divalent metal transporter1 (DMT1) in iron-mediated hepatic injury in HT mice.	Iron	150-154	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	141-145
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	aconitase 1	Homo sapiens	16-20
26921633-4	2016	KEY FINDINGS: TTCC and DMT1 blockers and DFO decreased liver iron and malondialdehyde (MDA) in HT mice indicating their antioxidant effects, whereas LTCC blocker produced no decrease in liver iron or MDA.	Iron	61-65	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	23-27
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	aconitase 1	Homo sapiens	251-255
26842892-4	2016	Using purified components, we demonstrated that Isu is indeed a substrate of the Lon-type protease and that it is protected from degradation by Nfs1, the sulfur donor for Fe-S cluster assembly, as well as by Jac1, the J-protein Hsp70 cochaperone that functions in cluster transfer from Isu.	Iron	171-175	NFS1 cysteine desulfurase	Homo sapiens	144-148
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	aconitase 1	Homo sapiens	16-20
28768766-3	2017	Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.	Iron	109-113	aconitase 1	Homo sapiens	251-255
28768766-7	2017	Iron supplementation reversed this growth defect and was associated with FBXL5-dependent polyubiquitination of IRP1.	Iron	0-4	aconitase 1	Homo sapiens	111-115
28768766-8	2017	Phosphorylation of IRP1 at Ser-138 increased when CIA was inhibited and was required for iron rescue.	Iron	89-93	aconitase 1	Homo sapiens	19-23
26797126-5	2016	Our findings suggest that IRP2 regulates the 24-h rhythm of transferrin receptor 1 (Tfr1) mRNA expression post-transcriptionally, by binding to RNA stem-loop structures known as iron-response elements.	Iron	178-182	transferrin receptor	Mus musculus	60-82
28825294-3	2017	Human Pirin, a nonheme iron (Fe) binding protein, has been shown to modulate the binding affinity between p65 homodimeric NF-kappaB and kappaB DNA.	Iron	23-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-109
26797126-5	2016	Our findings suggest that IRP2 regulates the 24-h rhythm of transferrin receptor 1 (Tfr1) mRNA expression post-transcriptionally, by binding to RNA stem-loop structures known as iron-response elements.	Iron	178-182	transferrin receptor	Mus musculus	84-88
26967262-1	2016	The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitumor target and a potential diagnostic marker for several tumor types, including prostate cancer.	Iron	29-33	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	41-47
28825294-3	2017	Human Pirin, a nonheme iron (Fe) binding protein, has been shown to modulate the binding affinity between p65 homodimeric NF-kappaB and kappaB DNA.	Iron	29-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-109
28787568-10	2017	On the basis of these results, we revealed that the heme iron center was not required for the inhibitory effect on hIAPP but affected the binding affinity of heme to hIAPP.	Iron	57-61	islet amyloid polypeptide	Homo sapiens	166-171
27004087-1	2016	This review focuses on the management of iron metabolism and iron overload experienced in the hereditary condition, human factors engineering (HFE)-associated hemochromatosis.	Iron	41-45	homeostatic iron regulator	Homo sapiens	143-146
27004087-1	2016	This review focuses on the management of iron metabolism and iron overload experienced in the hereditary condition, human factors engineering (HFE)-associated hemochromatosis.	Iron	61-65	homeostatic iron regulator	Homo sapiens	143-146
27004087-2	2016	Hemochromatosis refers to a group of genetic diseases that result in iron overload; the major one globally is HFE-associated hemochromatosis.	Iron	69-73	homeostatic iron regulator	Homo sapiens	110-113
28880952-2	2017	Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the efficiency of this process by oxidizing the transported iron to its ferric form and promoting its release from ferroportin.	Iron	98-102	hephaestin	Mus musculus	132-142
26812223-2	2016	Using second harmonic generation microscopy we found that fluoride doping of the microporous iron(iii) terephthalate MOF MIL-53(Fe) induces a polar organization in its structure, which was not previously detected with XRD.	Iron	128-130	lysine acetyltransferase 8	Homo sapiens	117-120
28880952-3	2017	Deletion or mutation of the hephaestin gene leads to systemic anemia with iron accumulation in the intestinal epithelium.	Iron	74-78	hephaestin	Mus musculus	28-38
28684612-4	2017	Three loci (rs1800562 and rs1799945 in the HFE gene and rs855791 in TMPRSS6) that are each associated with serum iron, transferrin saturation, ferritin, and transferrin in a pattern suggestive of an association with systemic iron status are used as instruments.	Iron	113-117	homeostatic iron regulator	Homo sapiens	43-46
28684612-4	2017	Three loci (rs1800562 and rs1799945 in the HFE gene and rs855791 in TMPRSS6) that are each associated with serum iron, transferrin saturation, ferritin, and transferrin in a pattern suggestive of an association with systemic iron status are used as instruments.	Iron	225-229	homeostatic iron regulator	Homo sapiens	43-46
28698302-11	2017	The results suggest that the ethynyl moiety of MS and OD faces the heme iron, whereas the isoxazole ring of DZ is preferentially oriented toward the heme iron of CYP2J2.	Iron	154-158	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	162-168
28474781-1	2017	INTRODUCTION: Since its discovery, the hemochromatosis protein HFE has been primarily defined by its role in iron metabolism and homeostasis, and its involvement in the genetic disease termed hereditary hemochromatosis (HH).	Iron	109-113	homeostatic iron regulator	Homo sapiens	63-66
28151915-2	2017	According to GWAS studies, iron regulatory protein HFE gene variant H63D (rs1799945) was associated with hypertension, an observation which we were able to confirm also in our TAMRISK cohort.	Iron	27-31	homeostatic iron regulator	Homo sapiens	51-54
28474781-6	2017	CONCLUSION: Overall, this increased understanding of the role of HFE in the immune response sets the stage for better treatment and management of HH and other iron-related diseases, as well as of the immune defects related to this condition.	Iron	159-163	homeostatic iron regulator	Homo sapiens	65-68
28695462-0	2017	Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain.	Iron	72-76	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	35-63
27755990-5	2017	This indicated that the inhibiting effect of ALA on DMT1 might be one of the causes of the ALA-induced reduction in cellular transferrin-bound-iron uptake.	Iron	143-147	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	52-56
27801963-0	2017	NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana.	Iron	57-61	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi	Arabidopsis thaliana	21-25
28695462-2	2017	Under normal circumstances, cellular iron and manganese uptake is regulated by the divalent metal transporter 1 (DMT1).	Iron	37-41	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	83-111
27900761-9	2017	Iron replacement decreased platelet counts in iron-depleted female donors (mean, -19,800/microL; interquartile range, 8000 to -45,000/muL), but not in donors who had normal or stable ferritin levels.	Iron	0-4	tripartite motif containing 37	Homo sapiens	134-137
28695462-2	2017	Under normal circumstances, cellular iron and manganese uptake is regulated by the divalent metal transporter 1 (DMT1).	Iron	37-41	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	113-117
28695462-5	2017	When fed with iron-supplemented diet, DMT1-expressing mice exhibit rather selective accumulation of iron in the substantia nigra, which is the principal region affected in human PD cases, but otherwise appear normal.	Iron	14-18	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	38-42
28695462-5	2017	When fed with iron-supplemented diet, DMT1-expressing mice exhibit rather selective accumulation of iron in the substantia nigra, which is the principal region affected in human PD cases, but otherwise appear normal.	Iron	100-104	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	38-42
28695462-7	2017	When DMT1 is overexpressed against a Parkin null background, the double-mutant mice similarly resisted a disease phenotype even when fed with iron- or manganese-supplemented diet.	Iron	142-146	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	5-9
28631167-0	2017	Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice (Oryza sativa L.).	Iron	79-83	copper transporter 1	Arabidopsis thaliana	67-72
28596835-9	2017	Lcn2 is known as an iron homeostasis-associated protein.	Iron	20-24	lipocalin 2	Mus musculus	0-4
28596835-13	2017	Furthermore, the DZP-induced upregulation of Lcn2 expression was influenced by ambient iron.	Iron	87-91	lipocalin 2	Mus musculus	45-49
28756660-5	2017	The exchange-coupling constant J (Hex = JS1 S2) was found to increase from +20 cm-1 to +32 cm-1 upon reduction of the diferric to the diferrous species, indicative of (1) at least one hydroxo bridge between the iron ions for both states and (2) a change to the diiron core structure upon reduction.	Iron	211-215	hematopoietically expressed homeobox	Homo sapiens	34-37
27776865-1	2017	Under the action of hydrogen peroxide, soil organic matter (SOM) can transform dissolved iron (Fe2+) into the solid phase.	Iron	89-93	grainyhead like transcription factor 3	Homo sapiens	60-63
27776865-2	2017	Solid iron is bound to SOM (Fe-SOM), and two components are included: iron oxides bound to SOM (Fe-SOM oxides) and organic iron bound to SOM (organic Fe-SOM).	Iron	6-10	grainyhead like transcription factor 3	Homo sapiens	23-26
27776865-8	2017	A large number of OH are generated near iron-SOM-oil interface.	Iron	40-44	grainyhead like transcription factor 3	Homo sapiens	45-48
28766335-4	2017	While E. coli IscS has a versatile role in the cell and was shown to have numerous interaction partners, NFS1 is mainly localized in mitochondria with a crucial role in the biosynthesis of Fe-S clusters.	Iron	189-193	NFS1 cysteine desulfurase	Homo sapiens	105-109
27569901-1	2017	BACKGROUND: Iron deficiency related gene, Femu2, encodes protein homologous to a C2H2-type zinc finger protein, which participates in the regulation of FOX1 gene induced by iron (Fe) deficiency in Chlamydomonas reinhardtii.	Iron	12-16	uncharacterized protein	Chlamydomonas reinhardtii	152-156
28766335-8	2017	Our results show that human NFS1 and E. coli IscS share conserved binding sites for proteins involved in Fe-S cluster assembly like IscU, but not with proteins for tRNA thio modifications or Moco biosynthesis.	Iron	105-107	NFS1 cysteine desulfurase	Homo sapiens	28-32
27569901-1	2017	BACKGROUND: Iron deficiency related gene, Femu2, encodes protein homologous to a C2H2-type zinc finger protein, which participates in the regulation of FOX1 gene induced by iron (Fe) deficiency in Chlamydomonas reinhardtii.	Iron	173-177	uncharacterized protein	Chlamydomonas reinhardtii	152-156
27569901-1	2017	BACKGROUND: Iron deficiency related gene, Femu2, encodes protein homologous to a C2H2-type zinc finger protein, which participates in the regulation of FOX1 gene induced by iron (Fe) deficiency in Chlamydomonas reinhardtii.	Iron	42-44	uncharacterized protein	Chlamydomonas reinhardtii	152-156
28766335-8	2017	Our results show that human NFS1 and E. coli IscS share conserved binding sites for proteins involved in Fe-S cluster assembly like IscU, but not with proteins for tRNA thio modifications or Moco biosynthesis.	Iron	105-107	NFS1 cysteine desulfurase	Homo sapiens	45-49
28786441-1	2017	Herein, a high-efficiency electrochemiluminescence (ECL) indicator of an abundant N-(aminobutyl)-N-(ethylisoluminol) functionalized metal-organic framework (ABEI@Fe-MIL-101) was synthesized to construct a biosensor for the ultrasensitive assay of mucin1 on MCF-7 cancer cells with a coreactant H2O2-free strategy.	Iron	162-164	mucin 1, cell surface associated	Homo sapiens	247-253
27686598-7	2017	The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1).	Iron	14-18	transferrin receptor	Mus musculus	78-100
28811531-5	2017	We found that Mtk specifically targets the iron-sulfur subunit (SdhB) of succinate-coenzyme Q reductase (SQR).	Iron	43-47	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	64-68
27686598-7	2017	The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1).	Iron	14-18	transferrin receptor	Mus musculus	102-106
27686598-7	2017	The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1).	Iron	14-18	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	112-140
27686598-7	2017	The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1).	Iron	14-18	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	169-173
27686598-7	2017	The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1).	Iron	146-150	transferrin receptor	Mus musculus	78-100
27686598-7	2017	The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1).	Iron	146-150	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	112-140
27923278-6	2017	Moreover, pharmacological and genetic activation of AMPK ameliorated hepcidin production, corrected iron dysregulation, and relieved hypoferremia and anemia in both acute and chronic inflammation models in mice.	Iron	100-104	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	52-56
28204974-5	2017	Ferroptosis is an iron-dependent non-apoptotic cell death that can elicited by pharmacological inhibiting the cystine/glutamate antiporter, system Xc- (type I) or directly binding and loss of activity of GPx4 (Type II) in cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression, but not in normal cells.	Iron	18-22	midkine	Mus musculus	259-262
28796976-1	2017	Hereditary hemochromatosis type 1 is an autosomal recessive disorder caused by HFE gene mutations, which is an iron homeostasis metabolism controlling co-factor.	Iron	111-115	homeostatic iron regulator	Homo sapiens	79-82
28715216-6	2017	Furthermore, LIH repressed almost 50% of the expression of FET3, FTR1, SIT1, and TIS11 genes in Saccharomyces cerevisiae cells, indicating increasing iron provided in cells and improved iron nutrition in citrus.	Iron	150-154	ferroxidase FET3	Saccharomyces cerevisiae S288C	59-63
28615439-3	2017	In this minireview, we discuss how discovery of the role of the mammalian cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characterization of the function of its Fe-S cluster in sensing and regulating cellular iron homeostasis.	Iron	189-193	aconitase 1	Homo sapiens	104-129
28615439-3	2017	In this minireview, we discuss how discovery of the role of the mammalian cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characterization of the function of its Fe-S cluster in sensing and regulating cellular iron homeostasis.	Iron	189-193	aconitase 1	Homo sapiens	131-135
28615439-3	2017	In this minireview, we discuss how discovery of the role of the mammalian cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characterization of the function of its Fe-S cluster in sensing and regulating cellular iron homeostasis.	Iron	104-108	aconitase 1	Homo sapiens	131-135
28785172-0	2017	Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes.	Iron	0-4	Rev	Human immunodeficiency virus 1	57-60
28785172-9	2017	Among them, the downregulation of the REV cofactor eIF5A may correlate with the iron-induced inhibition of HIV-1 gene expression.	Iron	80-84	Rev	Human immunodeficiency virus 1	38-41
28720726-1	2017	MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into the mitochondria.	Iron	43-47	Mge1p	Saccharomyces cerevisiae S288C	0-4
28389358-4	2017	Fes was identified as a novel direct target of miR-125b and miR-125b could also reduce the expression levels of PU.1 and macrophage colony-stimulating factor receptor (MCSFR).	Iron	0-3	colony stimulating factor 1 receptor	Homo sapiens	121-166
28389358-4	2017	Fes was identified as a novel direct target of miR-125b and miR-125b could also reduce the expression levels of PU.1 and macrophage colony-stimulating factor receptor (MCSFR).	Iron	0-3	colony stimulating factor 1 receptor	Homo sapiens	168-173
26415695-0	2016	Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System.	Iron	12-14	ferric reduction oxidase 2	Arabidopsis thaliana	117-121
28389358-5	2017	Furthermore, Fes was found to be involved in monocytic differentiation via upregulation of PU.1 and MCSFR and Fes siRNA could also inhibit 1,25D3-induced monocytic differentiation of U937 and HL60 cells and decrease mRNA expression of CD11c, CD18 and CD64.	Iron	13-16	colony stimulating factor 1 receptor	Homo sapiens	100-105
28389358-5	2017	Furthermore, Fes was found to be involved in monocytic differentiation via upregulation of PU.1 and MCSFR and Fes siRNA could also inhibit 1,25D3-induced monocytic differentiation of U937 and HL60 cells and decrease mRNA expression of CD11c, CD18 and CD64.	Iron	13-16	integrin subunit alpha X	Homo sapiens	235-240
26561754-1	2016	The zero-valent iron permeable reactive barrier (ZVI-PRB) is a promising technology for in-situ groundwater remediation.	Iron	16-20	RB transcriptional corepressor 1	Homo sapiens	53-56
28704474-1	2017	Heme is an efficient source of iron in the diet, and heme preparations are used to prevent and cure iron deficiency anemia in humans and animals.	Iron	31-35	HEME	Bos taurus	0-4
26944411-4	2016	RESULTS: We confirm previous results by showing that breast cancer epithelial cells present an "iron-utilization phenotype" with an increased expression of hepcidin and TFR1, and decreased expression of FT. On the other hand, lymphocytes and macrophages infiltrating primary tumors and from metastized lymph nodes display an "iron-donor" phenotype, with increased expression of FPN1 and FT, concomitant with an activation profile reflected by a higher expression of TFR1 and hepcidin.	Iron	96-100	transferrin receptor	Homo sapiens	169-173
26944411-4	2016	RESULTS: We confirm previous results by showing that breast cancer epithelial cells present an "iron-utilization phenotype" with an increased expression of hepcidin and TFR1, and decreased expression of FT. On the other hand, lymphocytes and macrophages infiltrating primary tumors and from metastized lymph nodes display an "iron-donor" phenotype, with increased expression of FPN1 and FT, concomitant with an activation profile reflected by a higher expression of TFR1 and hepcidin.	Iron	96-100	transferrin receptor	Homo sapiens	466-470
28706239-3	2017	Substantial amounts of FLVCR1 mRNA and protein levels were detected in AT, being significantly increased in subjects with T2D, and positively correlated with fasting glucose, fasting triglycerides and with circulating markers of iron stores (serum ferritin, blood hemoglobin and hematocrit).	Iron	229-233	FLVCR heme transporter 1	Rattus norvegicus	23-29
26852655-2	2016	Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4x10(-7)), which encodes the human hemochromatosis gene.	Iron	6-10	homeostatic iron regulator	Homo sapiens	175-178
26852655-3	2016	Association was also detected between percent iron saturation (p=10(-8)) and variants in the chromosome 6 region containing both HFE and SLC17A2, which encodes a phosphate transport protein.	Iron	46-50	homeostatic iron regulator	Homo sapiens	129-132
28515324-4	2017	Recent studies show that RNR cofactor biosynthesis shares the same source of iron, in the form of [2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for maturation of [4Fe-4S] clusters in cytosolic and nuclear proteins.	Iron	77-81	glutathione synthase	Saccharomyces cerevisiae S288C	107-111
26886577-9	2016	In contrast, cells lacking RGI1 were found to be hypersensitive to the toxic effects of iron.	Iron	88-92	Rgi1p	Saccharomyces cerevisiae S288C	27-31
26886577-10	2016	Overall, our results suggest that Rgi1p is a novel pro-survival protein whose function is not related to ferritin but nevertheless it may have a role in regulating yeast sensitivity to iron stress.	Iron	185-189	Rgi1p	Saccharomyces cerevisiae S288C	34-39
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	69-73	NFS1 cysteine desulfurase	Homo sapiens	5-9
28634302-2	2017	This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters.	Iron	69-73	frataxin	Homo sapiens	137-145
28615255-1	2017	Background: Total body iron (TBI) that is calculated from ferritin and soluble transferrin receptor (sTfR) allows for the evaluation of the full range of iron status from deficiency to excess.	Iron	23-27	transferrin receptor	Homo sapiens	79-99
26597663-5	2016	RESULTS: In HFE, the G-allele of rs1800562 was associated with lower iron stores in both sexes.	Iron	69-73	homeostatic iron regulator	Homo sapiens	12-15
28421266-4	2017	The data showed that iron-overloaded patients had a lower percentage of CD3+ T cells and disrupted T cell subsets, concomitant with higher ROS level in lymphocytes.	Iron	21-25	CD3 antigen, epsilon polypeptide	Mus musculus	72-75
26880306-1	2016	Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis.	Iron	43-47	transferrin receptor	Mus musculus	0-20
26880306-1	2016	Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis.	Iron	43-47	transferrin receptor	Mus musculus	22-25
28421266-6	2017	The results showed that iron overload could reduce the percentage of CD3+ T cells and the ratio of Th1/Th2 and Tc1/Tc2 but increase the percentage of regulatory T (Treg) cells and the ratio of CD4/CD8.	Iron	24-28	CD3 antigen, epsilon polypeptide	Mus musculus	69-72
28336129-4	2017	Catalase reduces the apparent Km(ascorbate) for both ascorbate and ascorbate+iron dependent mobilization by  80%.	Iron	77-81	catalase	Equus caballus	0-8
26861293-4	2016	We concentrated on the intestine, where the ferritin induction process can be controlled experimentally by dietary iron manipulation.	Iron	115-119	Ferritin 1 heavy chain homologue	Drosophila melanogaster	44-52
26861293-5	2016	We showed that the expression pattern of Fer2LCH-Gal4 lines recapitulated iron-dependent endogenous expression of the ferritin subunits and used these lines to drive expression from UAS-mCherry-Fer2LCH transgenes.	Iron	74-78	Ferritin 1 heavy chain homologue	Drosophila melanogaster	118-126
26861293-7	2016	Endogenous Fer2LCH and Fer1HCH assembled and stored excess dietary iron, instead.	Iron	67-71	Ferritin 1 heavy chain homologue	Drosophila melanogaster	23-30
26861293-8	2016	In contrast, when flies were genetically manipulated to co-express Fer2LCH and mCherry-Fer2LCH simultaneously, both subunits were incorporated with Fer1HCH in iron-loaded ferritin complexes.	Iron	159-163	Ferritin 1 heavy chain homologue	Drosophila melanogaster	148-155
26861293-8	2016	In contrast, when flies were genetically manipulated to co-express Fer2LCH and mCherry-Fer2LCH simultaneously, both subunits were incorporated with Fer1HCH in iron-loaded ferritin complexes.	Iron	159-163	Ferritin 1 heavy chain homologue	Drosophila melanogaster	171-179
28284069-2	2017	Fe@G-N was characterized by XRD, HRTEM, HAADF-STEM, FTIR, Raman spectroscopy, BET and zeta potential measurements, and then applied in adsorption of two kinds of anionic dyes, Acid Red 88 (AR88) and Direct Orange 26 (DO26).	Iron	0-2	delta/notch like EGF repeat containing	Homo sapiens	78-81
26845567-5	2016	Feeding of iron-deficient diet as well as erythropoietin treatment increased TMPRSS6 protein content in rats and mice by a posttranscriptional mechanism; the increase in TMPRSS6 protein by erythropoietin was also observed in Bmp6-mutant mice.	Iron	11-15	transmembrane serine protease 6	Mus musculus	170-177
26845567-6	2016	Administration of high doses of iron to mice (200, 350 and 700 mg/kg) decreased TMPRSS6 protein content.	Iron	32-36	transmembrane serine protease 6	Mus musculus	80-87
26845567-9	2016	Overall, the results demonstrate posttranscriptional regulation of liver TMPRSS6 protein by iron status and erythropoietin administration, and provide support for the interaction of TMPRSS6 and hemojuvelin proteins in vivo.	Iron	92-96	transmembrane serine protease 6	Mus musculus	73-80
28638917-3	2017	Iron regulatory proteins (IRPs) including IRP1 and IRP2 are cytosolic proteins that play important roles in maintaining cellular iron homeostasis.	Iron	129-133	aconitase 1	Homo sapiens	42-46
26948008-6	2016	RESULTS: Exposure to (56)Fe caused an increase in expression of alpha-smooth muscle cell actin, collagen type III, the inflammatory cell markers mast cell tryptase, CD2 and CD68, the endothelial glycoprotein thrombomodulin, and cleaved caspase 3.	Iron	25-27	CD2 antigen	Mus musculus	165-168
26948008-6	2016	RESULTS: Exposure to (56)Fe caused an increase in expression of alpha-smooth muscle cell actin, collagen type III, the inflammatory cell markers mast cell tryptase, CD2 and CD68, the endothelial glycoprotein thrombomodulin, and cleaved caspase 3.	Iron	25-27	CD68 antigen	Mus musculus	173-177
28629118-10	2017	This study indicates that long-term Dex exposure reduces liver iron content, which is closely associated with down-regulated hepatic TFR1 protein expression.	Iron	63-67	transferrin receptor	Rattus norvegicus	133-137
26560141-9	2016	Our results demonstrate that the concerted expression of AtIRT1, AtNAS1 and PvFERRITIN synergistically increases iron in both polished and unpolished rice grains.	Iron	113-117	nicotianamine synthase 1	Arabidopsis thaliana	65-71
26839325-3	2016	AbbVie developed a monoclonal antibody ([mAb]; repulsive guidance molecule [RGMa/c] mAb) that downregulates hepcidin expression by influencing the RGMc/bone morphogenetic protein (BMP)/neogenin receptor complex and causes iron deposition in the liver.	Iron	222-226	repulsive guidance molecule BMP co-receptor a	Rattus norvegicus	76-80
28747430-7	2017	Finally, we found that p53 played a role in iron homeostasis and was required for FDXR-mediated iron metabolism.	Iron	96-100	ferredoxin reductase	Mus musculus	82-86
27741349-6	2017	Six-month-old hepcidin KO mice showed cytoplasmic acinar iron overload and mild pancreatitis, together with elevated expression of the iron uptake mediators DMT1 and Zip14.	Iron	135-139	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	157-161
28747430-8	2017	Together, we conclude that FDXR and p53 are mutually regulated and that the FDXR-p53 loop is critical for tumor suppression via iron homeostasis.	Iron	128-132	ferredoxin reductase	Mus musculus	76-80
27741349-6	2017	Six-month-old hepcidin KO mice showed cytoplasmic acinar iron overload and mild pancreatitis, together with elevated expression of the iron uptake mediators DMT1 and Zip14.	Iron	135-139	solute carrier family 39 (zinc transporter), member 14	Mus musculus	166-171
29725541-4	2017	Herein, we report the synthesis of nano-ZVI stabilized by cellulose nanocrystal (CNC) rigid nanomaterials (CNC-nano-ZVI; Fe/CNC = 1 w/w) with two different CNC functional surfaces (-OH and -COOH) using a classic sodium borohydride synthesis pathway.	Iron	40-43	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	124-131
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-63	frataxin	Homo sapiens	474-477
28787888-6	2016	In high-Fe-containing Al-5Mg-Mn alloys (0.5 wt % Fe), intermetallic Al6(Fe,Mn) became the dominant phase, even in the alloy with low Mn content (0.39 wt %).	Iron	49-51	homeostatic iron regulator	Homo sapiens	3-10
26776506-0	2016	NCOA4 Deficiency Impairs Systemic Iron Homeostasis.	Iron	34-38	nuclear receptor coactivator 4	Mus musculus	0-5
28294512-4	2017	In this setting, mutations in the HFE gene of hereditary hemochromatosis may confer an adaptive benefit by decreasing hepcidin release, thus improving iron availability to erythropoiesis, anemia control, and the response to erythropoiesis stimulating agents and iron itself, and reducing the side effects of these therapies.	Iron	151-155	homeostatic iron regulator	Homo sapiens	34-37
26776506-2	2016	Here we show that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and spleen, increased levels of transferrin saturation, serum ferritin, and liver hepcidin, and decreased levels of duodenal ferroportin.	Iron	68-72	nuclear receptor coactivator 4	Mus musculus	18-23
26776506-8	2016	In conclusion, NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.	Iron	30-34	nuclear receptor coactivator 4	Mus musculus	15-20
26776506-8	2016	In conclusion, NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.	Iron	122-126	nuclear receptor coactivator 4	Mus musculus	15-20
26784172-1	2016	Iron is considered to play a key role in the development and progression of Multiple Sclerosis (MS).	Iron	0-4	MS	Homo sapiens	96-98
26784172-5	2016	Moreover, immunohistochemical investigations have helped defining the lesional and cellular distribution of iron in MS brain tissue.	Iron	108-112	MS	Homo sapiens	116-118
26784172-6	2016	Imaging studies in MS patients and of brain tissue combined with histological studies have provided important insights into the role of iron in inflammation and neurodegeneration in MS.	Iron	136-140	MS	Homo sapiens	19-21
26784172-6	2016	Imaging studies in MS patients and of brain tissue combined with histological studies have provided important insights into the role of iron in inflammation and neurodegeneration in MS.	Iron	136-140	MS	Homo sapiens	182-184
28735401-12	2017	Sulfite-generating ST activity is determined by colorimetric detection of SCN- formation at 460 nm as the red Fe(SCN)3 complex from cyanide and thiosulfate using acidic iron reagent.	Iron	169-173	HCLS1 associated protein X-1	Homo sapiens	113-118
28978826-4	2017	Various molecules, including HFE, transferrin receptor 2 (TFR2), and hemojuvelin (HJV), are involved in sensing systemic iron status.	Iron	121-125	homeostatic iron regulator	Homo sapiens	29-32
28203649-3	2016	We observed increased expression of heme and iron-regulated genes, previously shown to inhibit HIV-1, including ferroportin, IKBalpha, HO-1, p21, and SAM domain and HD domain-containing protein 1 (SAMHD1).	Iron	45-49	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	197-203
28294512-4	2017	In this setting, mutations in the HFE gene of hereditary hemochromatosis may confer an adaptive benefit by decreasing hepcidin release, thus improving iron availability to erythropoiesis, anemia control, and the response to erythropoiesis stimulating agents and iron itself, and reducing the side effects of these therapies.	Iron	262-266	homeostatic iron regulator	Homo sapiens	34-37
28294512-5	2017	The HFE protein together with Transferrin receptor-2 may also have a direct role on erythroid differentiation and iron uptake in erythroid cells.	Iron	114-118	homeostatic iron regulator	Homo sapiens	4-7
28727063-12	2017	Gastrin, insulin, TBA and cholesterol tended ( &lt; 0.10), or correlated ( &lt; 0.05) with P, K and Fe intake.	Iron	100-102	gastrin	Sus scrofa	0-7
28006025-5	2016	Functional analysis indicated that in the light group, the down-regulated iron-sulfur cluster assembly protein (Iba57) would decrease the synthesis of protoporphyrin IX; furthermore, the up-regulated protein solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5) and down-regulated translocator protein (TSPO) would lead to increased amounts of protoporphyrin IX transported into the mitochondria matrix to form heme with iron, which is supplied by ovotransferrin protein (TF).	Iron	74-78	solute carrier family 25 member 5	Gallus gallus	301-308
28006025-5	2016	Functional analysis indicated that in the light group, the down-regulated iron-sulfur cluster assembly protein (Iba57) would decrease the synthesis of protoporphyrin IX; furthermore, the up-regulated protein solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5) and down-regulated translocator protein (TSPO) would lead to increased amounts of protoporphyrin IX transported into the mitochondria matrix to form heme with iron, which is supplied by ovotransferrin protein (TF).	Iron	74-78	translocator protein	Gallus gallus	351-355
26741360-4	2016	Here we describe MIT1, a homolog of the mitochondrial iron importer genes mrs3 (yeast) and mitoferrin-1 (human) that is highly conserved among trypanosomatids.	Iron	54-58	Mit1p	Saccharomyces cerevisiae S288C	17-21
28537266-5	2017	These FRO2 allele dependent differences are coupled with altered seedling phenotypes grown on iron-limited soil.	Iron	94-98	ferric reduction oxidase 2	Arabidopsis thaliana	6-10
27669335-7	2016	Levels of mRNA for Tfr1 and Slc11a2, iron-responsive genes involved in iron uptake, were significantly elevated in DFO-treated cultures at 11DIV and 18DIV, indicating a degree of neuronal ID similar to that seen in rodent ID models.	Iron	37-41	transferrin receptor	Homo sapiens	19-23
27669335-7	2016	Levels of mRNA for Tfr1 and Slc11a2, iron-responsive genes involved in iron uptake, were significantly elevated in DFO-treated cultures at 11DIV and 18DIV, indicating a degree of neuronal ID similar to that seen in rodent ID models.	Iron	71-75	transferrin receptor	Homo sapiens	19-23
27768596-7	2016	Besides, we also found that MAZ increased the transcription level of ZNF217, and subsequently inhibited the FPN expression and their iron-related activities.	Iron	133-137	MYC associated zinc finger protein	Homo sapiens	28-31
27174123-1	2017	Hereditary hemochromatosis is an iron overburden condition, which is mainly governed by hereditary hemochromatosis factor E (HFE), a member of major histocompatibility complex class I.	Iron	33-37	homeostatic iron regulator	Homo sapiens	99-123
27208422-11	2016	Relatively high concentrations of transition metals, including Fe, Cu and Mn, may be responsible for the higher toxicity of sPM1 compared with uPM1.	Iron	63-65	splenomegaly modifier	Mus musculus	124-128
26370847-4	2016	Duodenal cytochrome b and divalent metal transporter 1, involved in apical iron uptake, are 8- and 10-fold, respectively, more abundant in the duodenum of germ-free (GF) mice than in mice colonized with a microbiota.	Iron	75-79	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	26-54
27174123-1	2017	Hereditary hemochromatosis is an iron overburden condition, which is mainly governed by hereditary hemochromatosis factor E (HFE), a member of major histocompatibility complex class I.	Iron	33-37	homeostatic iron regulator	Homo sapiens	125-128
27639899-4	2016	Therefore, metals (e.g., iron) could play an important role in the regulation of AMPK-dependent pathways.	Iron	25-29	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	81-85
27174123-8	2017	Hence, HFE is not available to bind again with transferrin receptor1 to negatively regulate iron homeostasis.	Iron	92-96	homeostatic iron regulator	Homo sapiens	7-10
26611621-8	2016	A western blot analysis revealed that iron feeding decreased total insulin receptor substrate 1 (IRS1), phosphorylated IRS1ser307, and AS160 but increased phosphorylated GSK-3beta.	Iron	38-42	glycogen synthase kinase 3 beta	Rattus norvegicus	170-179
26611621-9	2016	Iron supplementation inhibited the nuclear translocation of AKT but promoted FOXO1 translocation to nuclei.	Iron	0-4	forkhead box O1	Rattus norvegicus	77-82
27980236-2	2017	In the uterus, LCN2 may transport hydrophobic molecules and siderophores with iron, or may form a complex with another protein, however, the expression of uterine LCN2 beyond day 20 of equine pregnancy and its receptor has not been characterized.	Iron	78-82	lipocalin 2	Equus caballus	15-19
26100117-5	2016	We observed that the K101Q mutation (due to c. 301 A&gt;C mutation) may prevent the binding of [Fe-S] to GLRX5 protein, while L148S (due to c. 443 T&gt;C mutation) may interfere with [Fe-S] transfer from GLRX5 to iron regulatory protein 1 (IRP1), mitochondrial aconitase (m-aconitase) and ferrochelatase.	Iron	96-100	aconitase 1	Homo sapiens	213-238
26100117-5	2016	We observed that the K101Q mutation (due to c. 301 A&gt;C mutation) may prevent the binding of [Fe-S] to GLRX5 protein, while L148S (due to c. 443 T&gt;C mutation) may interfere with [Fe-S] transfer from GLRX5 to iron regulatory protein 1 (IRP1), mitochondrial aconitase (m-aconitase) and ferrochelatase.	Iron	96-100	aconitase 1	Homo sapiens	240-244
27095682-5	2016	In this study, the effect of hemochromatosis gene (HFE) p.H63D and p.C282Y mutations on transfusion-related cardiac and liver iron overload in sickle cell disease patients who carry homozygous hemoglobin S mutation has been investigated.	Iron	126-130	homeostatic iron regulator	Homo sapiens	51-54
27095682-14	2016	In addition, in group A, iron deposition was significantly higher in HFE mutation carriers compared to patients without the mutation (p=0.05).	Iron	25-29	homeostatic iron regulator	Homo sapiens	69-72
27095682-15	2016	CONCLUSION: Results of this study showed that HFE gene mutations are important in iron deposition in the liver in patients with sickle cell disease.	Iron	82-86	homeostatic iron regulator	Homo sapiens	46-49
31457166-2	2016	Binding studies have suggested that the oxidative state of iron plays a crucial role in modulating the binding of Pirin to NF-kappaB p65, in turn enhancing the binding of p65 to DNA.	Iron	59-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	123-136
28426722-3	2017	Previous studies suggested that mNT and NAF-1 could function in the same pathway in mammalian cells, preventing the over-accumulation of iron and reactive oxygen species (ROS) in mitochondria.	Iron	137-141	max binding protein	Mus musculus	32-35
31457166-2	2016	Binding studies have suggested that the oxidative state of iron plays a crucial role in modulating the binding of Pirin to NF-kappaB p65, in turn enhancing the binding of p65 to DNA.	Iron	59-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	133-136
27827297-10	2016	Non-HFE gene mutations may predispose HH patients to iron deposition in the brain.	Iron	53-57	homeostatic iron regulator	Homo sapiens	4-7
26661838-8	2016	RESULTS: Better iron status was associated with better attention [faster reaction time (RT) with lower TfR (P = 0.028) and higher TSAT (P = 0.013)], inhibitory control [lower RT variability with higher TSAT (P = 0.042) and planning ability (faster planning time and a smaller planning time increase with increasing difficulty with higher ferritin; P = 0.010)].	Iron	16-20	transferrin receptor	Homo sapiens	103-106
26661838-10	2016	Paradoxically, worse performance on a working memory task was related to better iron status, which may reflect hippocampal-frontal interference [lower capacity with lower TfR (P = 0.034) and higher TBI (P = 0.043) and a larger accuracy change with increasing difficulty with higher TBI (P = 0.016)].	Iron	80-84	transferrin receptor	Homo sapiens	171-174
28426722-7	2017	Our study highlights the possibility that mNT and NAF-1 function as part of an iron-sulfur (2Fe-2S) cluster relay to maintain the levels of iron and Fe-S clusters under control in the mitochondria of mammalian cells, thereby preventing the activation of apoptosis and/or autophagy and supporting cellular proliferation.	Iron	79-83	max binding protein	Mus musculus	42-45
26711111-2	2016	A new study identified a mutation affecting the iron import receptor TfR1 as the cause of a human primary immunodeficiency, illuminating the importance of iron in immune cell function.	Iron	48-52	transferrin receptor	Homo sapiens	69-73
28426722-7	2017	Our study highlights the possibility that mNT and NAF-1 function as part of an iron-sulfur (2Fe-2S) cluster relay to maintain the levels of iron and Fe-S clusters under control in the mitochondria of mammalian cells, thereby preventing the activation of apoptosis and/or autophagy and supporting cellular proliferation.	Iron	140-144	max binding protein	Mus musculus	42-45
28426722-7	2017	Our study highlights the possibility that mNT and NAF-1 function as part of an iron-sulfur (2Fe-2S) cluster relay to maintain the levels of iron and Fe-S clusters under control in the mitochondria of mammalian cells, thereby preventing the activation of apoptosis and/or autophagy and supporting cellular proliferation.	Iron	149-153	max binding protein	Mus musculus	42-45
27708122-2	2016	OBJECTIVE: The objective of this study was to determine dietary iron requirements of broilers for the full expression of succinate dehydrogenase (SDH), catalase, and cytochrome c oxidase (COX) in various tissues.	Iron	64-68	catalase-3	Glycine max	152-160
28375145-4	2017	Here, the first crystal structure of human 3HAO with the native iron bound in its active site is presented, together with an additional structure with zinc (a known inhibitor of human 3HAO) bound in the active site.	Iron	64-68	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	43-47
27667161-4	2016	This study aimed to explore the use of next-generation sequencing (NGS) technology to analyse a panel of iron metabolism-related genes (HFE, TFR2, HJV, HAMP, SLC40A1, and FTL) in 87 non-classic HH Portuguese patients.	Iron	105-109	homeostatic iron regulator	Homo sapiens	136-139
27293957-3	2016	Mitochondrial dysfunction results not only in increased reactive oxygen species production but also in decreased iron-sulfur cluster synthesis and unorthodox activation of Iron Regulatory Protein 1 (IRP1), a key regulator of cell iron homeostasis.	Iron	230-234	aconitase 1	Homo sapiens	172-197
27293957-3	2016	Mitochondrial dysfunction results not only in increased reactive oxygen species production but also in decreased iron-sulfur cluster synthesis and unorthodox activation of Iron Regulatory Protein 1 (IRP1), a key regulator of cell iron homeostasis.	Iron	230-234	aconitase 1	Homo sapiens	199-203
27293957-4	2016	In turn, IRP1 activation results in iron accumulation and hydroxyl radical-mediated damage.	Iron	36-40	aconitase 1	Homo sapiens	9-13
28019068-0	2017	Using iron studies to predict HFE mutations in New Zealand: implications for laboratory testing.	Iron	6-10	homeostatic iron regulator	Homo sapiens	30-33
26671928-4	2015	TET proteins (TET1, TET2, TET3) are iron(II) and alpha-ketoglutarate dependent dioxygenases, and their enzymatic activity involves hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine and 5-carboxylcytosine.	Iron	36-40	tet methylcytosine dioxygenase 2	Homo sapiens	20-24
27402672-4	2016	Across statistical analyses, maternal Fe status was consistently associated with the placental nonheme Fe importer transferrin receptor 1 (TfR1).	Iron	38-40	transferrin receptor	Homo sapiens	115-137
27402672-4	2016	Across statistical analyses, maternal Fe status was consistently associated with the placental nonheme Fe importer transferrin receptor 1 (TfR1).	Iron	38-40	transferrin receptor	Homo sapiens	139-143
27784128-1	2017	BACKGROUND AND AIM: Women who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload-related disease than p.C282Y homozygous men, presumably because of the iron-depleting effects of menstruation and pregnancy.	Iron	112-116	homeostatic iron regulator	Homo sapiens	77-80
26992127-0	2016	The modified iron avidity index: a promising phenotypic predictor in HFE-related haemochromatosis.	Iron	13-17	homeostatic iron regulator	Homo sapiens	69-72
27107905-1	2016	FANCJ is a superfamily 2 DNA helicase, which also belongs to the iron-sulfur domain containing helicases that include XPD, ChlR1 (DDX11), and RTEL1.	Iron	65-69	regulator of telomere elongation helicase 1	Homo sapiens	142-147
26690219-0	2015	Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks.	Iron	77-81	homeostatic iron regulator	Homo sapiens	23-26
26690219-1	2015	BACKGROUND: Polymorphisms in the hemochromatosis (HFE) gene are associated with excessive iron absorption from the diet, and pro-oxidant effects of iron accumulation are thought to be a risk factor for several types of cancer.	Iron	90-94	homeostatic iron regulator	Homo sapiens	50-53
26690219-1	2015	BACKGROUND: Polymorphisms in the hemochromatosis (HFE) gene are associated with excessive iron absorption from the diet, and pro-oxidant effects of iron accumulation are thought to be a risk factor for several types of cancer.	Iron	148-152	homeostatic iron regulator	Homo sapiens	50-53
26416567-1	2015	The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis.	Iron	43-47	homeostatic iron regulator	Homo sapiens	4-7
27503603-0	2016	Glutaredoxin GRXS17 Associates with the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Iron	50-54	thioredoxin family protein	Arabidopsis thaliana	13-19
27784128-1	2017	BACKGROUND AND AIM: Women who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload-related disease than p.C282Y homozygous men, presumably because of the iron-depleting effects of menstruation and pregnancy.	Iron	197-201	homeostatic iron regulator	Homo sapiens	77-80
27503603-3	2016	Arabidopsis (Arabidopsis thaliana) has a sole class II cytosolic monothiol GRX encoded by GRXS17 Here, we used tandem affinity purification to establish that Arabidopsis GRXS17 associates with most known cytosolic Fe-S assembly (CIA) components.	Iron	214-218	thioredoxin family protein	Arabidopsis thaliana	170-176
28315258-7	2017	Various conserved proteins, such as ABC mitochondrial transporter Atm1 and, for Aft1/Aft2, monothiol glutaredoxins Grx3 and Grx4 are implicated in this iron-signaling pathway.	Iron	152-156	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	66-70
27503603-5	2016	We also found that several putative Fe-S client proteins directly bind to GRXS17, such as XANTHINE DEHYDROGENASE1 (XDH1), involved in the purine salvage pathway, and CYTOSOLIC THIOURIDYLASE SUBUNIT1 and CYTOSOLIC THIOURIDYLASE SUBUNIT2, both essential for the 2-thiolation step of 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification of tRNAs.	Iron	36-40	thioredoxin family protein	Arabidopsis thaliana	74-80
25761647-0	2015	Iron regulation of hepcidin through Hfe and Hjv: Common or distinct pathways?	Iron	0-4	homeostatic iron regulator	Homo sapiens	36-39
28421781-6	2017	In relation to industrial porridges (PIH), those of "rice", "wheat with milk" and "5 cereals" they had a higher content of Fe (9.4, 8.53 and 7.56 mg Fe/100 g, respectively).	Iron	123-125	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	37-40
26666282-3	2015	Identification of genetic variants is an important part of the diagnostic process, e. g. the majority of patients with high iron [Fe] (HFE)-associated hemochromatosis carry the homozygous mutation p.C282Y.	Iron	124-128	homeostatic iron regulator	Homo sapiens	135-138
27661980-2	2016	Symptoms of PCT resolve when iron stores are depleted by phlebotomy, and a sequence variant of HFE (C282Y, c.843G&gt;A, rs1800562) that enhances iron aborption by reducing hepcidin expression is a risk factor for PCT.	Iron	145-149	homeostatic iron regulator	Homo sapiens	95-98
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	245-249	homeostatic iron regulator	Homo sapiens	196-199
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	245-249	homeostatic iron regulator	Homo sapiens	295-298
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	homeostatic iron regulator	Homo sapiens	196-199
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	homeostatic iron regulator	Homo sapiens	295-298
26666282-3	2015	Identification of genetic variants is an important part of the diagnostic process, e. g. the majority of patients with high iron [Fe] (HFE)-associated hemochromatosis carry the homozygous mutation p.C282Y.	Iron	130-132	homeostatic iron regulator	Homo sapiens	135-138
28189691-4	2017	Therefore, we developed human IgG monoclonal antibodies to human TFR1 using a phage display method (ICOS method) to block the incorporation of the transferrin (TF)-iron complex into ATLL cells for inhibiting cell growth.	Iron	164-168	transferrin receptor	Homo sapiens	65-69
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	homeostatic iron regulator	Homo sapiens	196-199
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	homeostatic iron regulator	Homo sapiens	295-298
28130443-11	2017	We propose that NHE9 regulates TfR-dependent, recycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH in response to paracrine signals and is therefore an important regulator in iron mobilization pathway at the BBB.	Iron	68-72	transferrin receptor	Homo sapiens	31-34
27604472-7	2016	The main predictor of being FE among all grades of COPD severity was a history of frequent exacerbations in the previous year: adjusted OR 4.97; 95% confidence interval (CI) (3.54-6.97).	Iron	28-30	COPD	Homo sapiens	51-55
26703568-2	2015	The regulatory function and potential role of miRNAs targeting the mRNA of the 5"-aminolevulinate synthase 2 (ALAS2) in erythropoiesis were investigated in order to identify miRNAs which play a role in erythroid iron metabolism and differentiation.	Iron	212-216	5'-aminolevulinate synthase 2	Homo sapiens	79-108
26703568-2	2015	The regulatory function and potential role of miRNAs targeting the mRNA of the 5"-aminolevulinate synthase 2 (ALAS2) in erythropoiesis were investigated in order to identify miRNAs which play a role in erythroid iron metabolism and differentiation.	Iron	212-216	5'-aminolevulinate synthase 2	Homo sapiens	110-115
26703568-7	2015	Taken together, our results show that miR-218 inhibits erythroid differentiation and alters iron metabolism by targeting ALAS2 in K562 cells.	Iron	92-96	5'-aminolevulinate synthase 2	Homo sapiens	121-126
26635519-1	2015	Reduced levels of frataxin, an essential mitochondrial protein involved in the regulation of iron-sulfur cluster biogenesis, are responsible for the recessive neurodegenerative Friedreich Ataxia (FRDA).	Iron	93-97	frataxin	Homo sapiens	18-26
27390324-1	2016	Divalent metal-ion transporter-1 (DMT1), the principal mechanism by which nonheme iron is taken up at the intestinal brush border, is energized by the H(+)-electrochemical potential gradient.	Iron	82-86	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-32
27390324-1	2016	Divalent metal-ion transporter-1 (DMT1), the principal mechanism by which nonheme iron is taken up at the intestinal brush border, is energized by the H(+)-electrochemical potential gradient.	Iron	82-86	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	34-38
28130443-11	2017	We propose that NHE9 regulates TfR-dependent, recycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH in response to paracrine signals and is therefore an important regulator in iron mobilization pathway at the BBB.	Iron	199-203	transferrin receptor	Homo sapiens	31-34
27390324-8	2016	Our data point to an important role for NHE3 in generating the H(+) gradient that drives DMT1-mediated iron uptake at the intestinal brush border.	Iron	103-107	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	89-93
28224156-13	2017	The results of the present study demonstrate the utility of HL1, HL2 and H2L3 in the stabilisation of robust iron(iii)/oxido/alkoxido clusters.	Iron	109-113	intelectin 2	Homo sapiens	65-68
27589737-6	2016	Iron chelators enhanced expressions of NDRG1 and NDRG3 while repressing cyclin D1 expression in OSCC cells.	Iron	0-4	cyclin D1	Homo sapiens	72-81
26497993-0	2015	SCP2 mutations and neurodegeneration with brain iron accumulation.	Iron	48-52	sterol carrier protein 2	Homo sapiens	0-4
26597277-12	2015	We showed that AG3 luminal B tumours were less aggressive than AG1 luminal B tumours based on different GES (iron metabolism, mitochondrial oxidative phosphorylation and reactive stroma), recurrence score prognostic GES and histological grade (SBR).	Iron	109-113	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	15-18
27753142-3	2017	A total of 190 patients were sequenced: 94 from a tertiary hemochromatosis clinic and 96 submitted for HFE testing with biochemical evidence of iron overload [elevated ferritin (&gt;450 mug/L) or transferrin saturation (&gt;55%)] obtained from a chart review.	Iron	144-148	homeostatic iron regulator	Homo sapiens	103-106
20301759-6	1993	MANAGEMENT: Treatment of manifestations: Intramuscular or subcutaneous injections of interferon (IFN)-alpha2a or INF-alpha2b given two or three times a week increase hemoglobin and decrease iron overload in the majority of treated individuals.	Iron	190-194	interferon alpha 2	Homo sapiens	85-109
28293251-0	2017	An active Mitochondrial Complex II Present in Mature Seeds Contains an Embryo-Specific Iron-Sulfur Subunit Regulated by ABA and bZIP53 and Is Involved in Germination and Seedling Establishment.	Iron	87-91	basic region/leucine zipper motif 53	Arabidopsis thaliana	128-134
20301759-6	1993	MANAGEMENT: Treatment of manifestations: Intramuscular or subcutaneous injections of interferon (IFN)-alpha2a or INF-alpha2b given two or three times a week increase hemoglobin and decrease iron overload in the majority of treated individuals.	Iron	190-194	interferon alpha 17	Homo sapiens	113-122
27558773-3	2016	We investigated long-term effects of (56)Fe radiation on adipokines and insulin-like growth factor 1 (IGF1) signaling axis in mouse intestine and colon.	Iron	41-43	insulin-like growth factor 1	Mus musculus	72-100
26332507-7	2015	Overexpression of the iron exporter ferroportin-1 in Lcn2(-/-) macrophages represses IL-10 and restores TNF-alpha and IL-6 production to the levels found in wild-type macrophages, so that killing and clearance of intracellular Salmonella is promoted.	Iron	22-26	lipocalin 2	Mus musculus	53-57
26332507-8	2015	Our observations suggest that Lcn2 promotes host resistance to Salmonella Typhimurium infection by binding bacterial siderophores and suppressing IL-10 production, and that both functions are linked to its ability to shuttle iron from macrophages.	Iron	225-229	lipocalin 2	Mus musculus	30-34
26333047-9	2015	The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1.	Iron	26-28	ferric reduction oxidase 2	Arabidopsis thaliana	53-57
28955733-4	2017	We have demonstrated that PBR-Associated Protein 7 (PAP7) bound to the Iron Responsive Element (IRE) isoform of divalent metal transporter 1 (DMT1).	Iron	71-75	acyl-CoA binding domain containing 3	Homo sapiens	26-50
26333047-9	2015	The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1.	Iron	203-205	ferric reduction oxidase 2	Arabidopsis thaliana	53-57
27245739-5	2016	Knockout or knockdown of Atg5 (autophagy-related 5) and Atg7 limited erastin-induced ferroptosis with decreased intracellular ferrous iron levels, and lipid peroxidation.	Iron	126-138	autophagy related 7	Homo sapiens	56-60
28955733-4	2017	We have demonstrated that PBR-Associated Protein 7 (PAP7) bound to the Iron Responsive Element (IRE) isoform of divalent metal transporter 1 (DMT1).	Iron	71-75	acyl-CoA binding domain containing 3	Homo sapiens	52-56
28082676-4	2017	Miner2 is a member of a new CDGSH iron-sulfur protein family that also includes two mitochondrial proteins: the type II diabetes-related mitoNEET and the Wolfram syndrome 2-linked Miner1.	Iron	34-38	CDGSH iron sulfur domain 3	Homo sapiens	0-6
27377930-9	2016	It is concluded that saturation of apo-LF with iron, provided by active CP, can strongly affect its protective capacity.	Iron	47-51	ceruloplasmin	Rattus norvegicus	72-74
26501199-0	2015	Carriers of the Complex Allele HFE c.[187C&gt;G;340+4T&gt;C] Have Increased Risk of Iron Overload in Sao Miguel Island Population (Azores, Portugal).	Iron	84-88	homeostatic iron regulator	Homo sapiens	31-34
26501199-1	2015	Iron overload is associated with acquired and genetic conditions, the most common being hereditary hemochromatosis (HH) type-I, caused by HFE mutations.	Iron	0-4	homeostatic iron regulator	Homo sapiens	138-141
26501199-9	2015	Finally, we investigated HFE mutations configuration with iron overload by determining haplotypes and genotypic profiles.	Iron	58-62	homeostatic iron regulator	Homo sapiens	25-28
26501199-11	2015	This data is corroborated by the association analysis where carriers of the complex allele HFE-c.[187C&gt;G;340+4T&gt;C] have an increased iron overload risk (RR = 2.08, 95% CI = 1.40-2.94, p&lt;0.001).	Iron	139-143	homeostatic iron regulator	Homo sapiens	91-94
26501199-13	2015	In summary, we provide evidence that the complex allele HFE-c.[187C&gt;G;340+4T&gt;C] has a role, as genetic predisposition factor, on iron overload in the Sao Miguel population.	Iron	135-139	homeostatic iron regulator	Homo sapiens	56-59
27343690-9	2016	Interestingly, exposure to exogenous iron increased membrane association and co-localization of alpha-syn with TfR, supporting its role in iron uptake by the Tf/TfR complex.	Iron	37-41	transferrin receptor	Homo sapiens	111-114
27343690-9	2016	Interestingly, exposure to exogenous iron increased membrane association and co-localization of alpha-syn with TfR, supporting its role in iron uptake by the Tf/TfR complex.	Iron	37-41	transferrin receptor	Homo sapiens	161-164
27343690-9	2016	Interestingly, exposure to exogenous iron increased membrane association and co-localization of alpha-syn with TfR, supporting its role in iron uptake by the Tf/TfR complex.	Iron	139-143	transferrin receptor	Homo sapiens	111-114
27343690-9	2016	Interestingly, exposure to exogenous iron increased membrane association and co-localization of alpha-syn with TfR, supporting its role in iron uptake by the Tf/TfR complex.	Iron	139-143	transferrin receptor	Homo sapiens	161-164
26342079-6	2015	Due to altered interaction with ISD11 mutants, the levels of NFS1 and Isu1 were significantly depleted, which affects Fe-S cluster biosynthesis, leading to reduced electron transport chain complex (ETC) activity and mitochondrial respiration.	Iron	118-122	NFS1 cysteine desulfurase	Homo sapiens	61-65
28082676-6	2017	Binding of nitric oxide in the reduced Miner2 [2Fe-2S] clusters produces a major absorption peak at 422 nm without releasing iron or sulfide from the clusters.	Iron	125-129	CDGSH iron sulfur domain 3	Homo sapiens	39-45
28193002-4	2017	In the present study, organic cyanide (4-mercaptobenzonitrile, MBN) was utilized for the first time in developing a facile nanoprobe based on surface-enhanced Raman scattering (SERS) for quantitative detection of hemeproteins (oxy-Hb) and trivalent iron (Fe3+) ions.	Iron	249-253	proteinase 3	Homo sapiens	63-66
26492035-0	2015	MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis.	Iron	29-33	ARM repeat superfamily protein	Arabidopsis thaliana	0-5
26492035-4	2015	Map-based cloning identified ASI3 as MET18, a component of the cytosolic iron-sulfur cluster assembly (CIA) pathway.	Iron	73-77	ARM repeat superfamily protein	Arabidopsis thaliana	37-42
26492035-9	2015	Our results suggest that ROS1-mediated active DNA demethylation requires MET18-dependent transfer of the iron-sulfur cluster, highlighting an important role of the CIA pathway in epigenetic regulation.	Iron	105-109	ARM repeat superfamily protein	Arabidopsis thaliana	73-78
27206843-10	2016	We propose the following cascade for Lead (Pb) toxicity to neurons; by targeting the interaction between Iron regulatory protein-1 and Iron-responsive elements, Pb caused translational repression of proteins that control intracellular iron homeostasis, including the Alzheimer"s amyloid precursor protein (APP) that stabilizes the iron exporter ferroportin, and the ferroxidase heavy subunit of the iron-storage protein, ferritin.	Iron	235-239	aconitase 1	Homo sapiens	105-130
27206843-10	2016	We propose the following cascade for Lead (Pb) toxicity to neurons; by targeting the interaction between Iron regulatory protein-1 and Iron-responsive elements, Pb caused translational repression of proteins that control intracellular iron homeostasis, including the Alzheimer"s amyloid precursor protein (APP) that stabilizes the iron exporter ferroportin, and the ferroxidase heavy subunit of the iron-storage protein, ferritin.	Iron	331-335	aconitase 1	Homo sapiens	105-130
27206843-10	2016	We propose the following cascade for Lead (Pb) toxicity to neurons; by targeting the interaction between Iron regulatory protein-1 and Iron-responsive elements, Pb caused translational repression of proteins that control intracellular iron homeostasis, including the Alzheimer"s amyloid precursor protein (APP) that stabilizes the iron exporter ferroportin, and the ferroxidase heavy subunit of the iron-storage protein, ferritin.	Iron	331-335	aconitase 1	Homo sapiens	105-130
28134365-1	2017	Ndi1 is a special type-II complex I nicotinamide-adenine-dinucleotide (NADH):ubiquinone (UQ) oxidoreductase in the yeast respiratory chain, with two bound UQs (UQI and UQII) mediating electron transfer from flavin cofactors to ubiquinone, in the absence of Fe-S chains.	Iron	257-261	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	0-4
27307498-0	2016	Transferrin receptor mRNA interactions contributing to iron homeostasis.	Iron	55-59	transferrin receptor	Homo sapiens	0-20
27307498-2	2016	The 3" UTR of the transferrin receptor mRNA contains an instability element that is protected from degradation during iron depletion through interactions of iron regulatory proteins (IRPs) with five iron-responsive elements (IREs).	Iron	118-122	transferrin receptor	Homo sapiens	18-38
27307498-2	2016	The 3" UTR of the transferrin receptor mRNA contains an instability element that is protected from degradation during iron depletion through interactions of iron regulatory proteins (IRPs) with five iron-responsive elements (IREs).	Iron	157-161	transferrin receptor	Homo sapiens	18-38
27307498-2	2016	The 3" UTR of the transferrin receptor mRNA contains an instability element that is protected from degradation during iron depletion through interactions of iron regulatory proteins (IRPs) with five iron-responsive elements (IREs).	Iron	157-161	transferrin receptor	Homo sapiens	18-38
27307498-8	2016	These results are supportive of a mechanism for a graded response to the intracellular iron resulting from a progressive loss of IRP protection.	Iron	87-91	Wnt family member 2	Homo sapiens	129-132
26294671-0	2015	Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese.	Iron	32-36	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	11-15
26294671-1	2015	Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization.	Iron	62-66	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-32
26294671-1	2015	Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization.	Iron	62-66	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	34-38
26294671-1	2015	Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization.	Iron	146-150	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-32
26294671-1	2015	Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization.	Iron	146-150	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	34-38
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	27-31	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	93-97
26294671-5	2015	We observed decreased total iron content in multiple tissues from DMT1(int/int) mice compared with DMT1(+/+) mice but no meaningful change in copper, manganese, or zinc.	Iron	28-32	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	66-70
26294671-6	2015	DMT1(int/int) mice absorbed (64)Cu and (54)Mn from an intragastric dose to the same extent as did DMT1(+/+) mice but the absorption of (59)Fe was virtually abolished in DMT1(int/int) mice.	Iron	139-141	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
26294671-7	2015	This study reveals a critical function for DMT1 in intestinal nonheme-iron absorption for normal growth and development.	Iron	70-74	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	43-47
27433942-2	2016	One of the hallmarks of the disease is the accumulation of iron in several tissues including the brain, and frataxin has been proposed to play a key role in iron homeostasis.	Iron	157-161	frataxin	Drosophila melanogaster	108-116
27433942-4	2016	By means of a candidate genetic screen, we identified that genes implicated in iron, zinc and copper transport and metal detoxification can restore frataxin deficiency-induced phenotypes.	Iron	79-83	frataxin	Drosophila melanogaster	148-156
28223994-7	2017	We previously reported that AtIRT1, when expressed together with AtNAS1 and PvFERRITIN (PvFER) in high-iron (NFP) rice, has a synergistic effect of further increasing the iron concentration of polished rice grains.	Iron	171-175	nicotianamine synthase 1	Arabidopsis thaliana	65-71
27427956-1	2016	The eukaryotic protein Isd11 is a chaperone that binds and stabilizes the central component of the essential metabolic pathway responsible for formation of iron-sulfur clusters in mitochondria, the desulfurase Nfs1.	Iron	156-160	NFS1 cysteine desulfurase	Homo sapiens	210-214
26461092-4	2015	Systematic interrogation of iron flux determined that CSCs preferentially require transferrin receptor and ferritin, two core iron regulators, to propagate and form tumors in vivo.	Iron	28-32	transferrin receptor	Homo sapiens	82-102
28223994-10	2017	All the single insertion transgenic lines have significant increases of iron concentration, both in polished and unpolished grains, but the concerted expression of AtIRT1, AtNAS1, and PvFER resulted to be a more effective strategy in achieving the highest iron increases of up to 10.46 mug/g dry weight.	Iron	256-260	nicotianamine synthase 1	Arabidopsis thaliana	172-178
26610684-0	2016	Heme Iron Release from Alginate Beads at In Vitro Simulated Gastrointestinal Conditions.	Iron	5-9	HEME	Bos taurus	0-4
28174279-7	2017	Conditional deletion of both Bcl9 and Bcl9l or both Pygo1 and Pygo2 in mice produced teeth with defective enamel that was bright white and deficient in iron, which is reminiscent of human tooth enamel pathologies.	Iron	152-156	B cell CLL/lymphoma 9-like	Mus musculus	38-43
26610684-1	2016	Heme iron (Fe) release from alginate beads at in vitro simulated gastrointestinal conditions for potential use as oral heme Fe supplement was studied.	Iron	5-9	HEME	Bos taurus	0-4
26610684-1	2016	Heme iron (Fe) release from alginate beads at in vitro simulated gastrointestinal conditions for potential use as oral heme Fe supplement was studied.	Iron	11-13	HEME	Bos taurus	0-4
26610684-5	2016	The heme Fe-beads in simulated gastric fluid (pH 2) remained in a shrinkage state and Fe release was low: 25.8, 21.1, 11.6, 12.1, and 12.0 % for 1:1.25, 1:2.5, 1:5, 1:10, and 1:15 ratios, respectively.	Iron	9-11	HEME	Bos taurus	4-8
26610684-7	2016	The heme Fe-beads swelled and dissociated in simulated intestinal fluid (pH 6), releasing three-fourths of the Fe in 200 min.	Iron	9-11	HEME	Bos taurus	4-8
26610684-7	2016	The heme Fe-beads swelled and dissociated in simulated intestinal fluid (pH 6), releasing three-fourths of the Fe in 200 min.	Iron	111-113	HEME	Bos taurus	4-8
26500891-0	2015	Decreased RXRalpha is Associated with Increased beta-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors.	Iron	73-75	retinoid X receptor alpha	Mus musculus	10-18
26500891-3	2015	Employing an APC-mutant mouse model (APC(Min/+)) the present study aimed to investigate the status of RXRalpha, an APC-independent factor involved in targeting beta-catenin to UPP for degradation, in tumor-bearing and tumor-free areas of intestine after exposure to energetic (56)Fe ions.	Iron	280-282	retinoid X receptor alpha	Mus musculus	102-110
26500891-8	2015	This indicates that decreased UPP targeting of beta-catenin due to downregulation of RXRalpha can contribute to further accumulation of beta-catenin and to (56)Fe-induced tumorigenesis.	Iron	160-162	retinoid X receptor alpha	Mus musculus	85-93
26610684-9	2016	These results indicate that heme Fe-beads may be useful for oral delivery of heme Fe supplement.	Iron	33-35	HEME	Bos taurus	28-32
26610684-9	2016	These results indicate that heme Fe-beads may be useful for oral delivery of heme Fe supplement.	Iron	33-35	HEME	Bos taurus	77-81
28143845-3	2017	Even when expressed as a heterozygote, the Nan-EKLF protein accomplishes this by direct binding and aberrant activation of genes encoding secreted factors that exert a negative effect on erythropoiesis and iron use.	Iron	206-210	Kruppel like factor 1	Homo sapiens	47-51
26610684-9	2016	These results indicate that heme Fe-beads may be useful for oral delivery of heme Fe supplement.	Iron	82-84	HEME	Bos taurus	28-32
26610684-9	2016	These results indicate that heme Fe-beads may be useful for oral delivery of heme Fe supplement.	Iron	82-84	HEME	Bos taurus	77-81
26436293-5	2015	Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.	Iron	78-82	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Danio rerio	127-132
26436293-7	2015	This work reveals the molecular nature of the NCOA4-ferritin complex and explains how intracellular iron levels modulate NCOA4-mediated ferritinophagy in cells and in an iron-dependent physiological setting.	Iron	100-104	nuclear receptor coactivator 4	Danio rerio	46-51
26436293-7	2015	This work reveals the molecular nature of the NCOA4-ferritin complex and explains how intracellular iron levels modulate NCOA4-mediated ferritinophagy in cells and in an iron-dependent physiological setting.	Iron	100-104	nuclear receptor coactivator 4	Danio rerio	121-126
26436293-7	2015	This work reveals the molecular nature of the NCOA4-ferritin complex and explains how intracellular iron levels modulate NCOA4-mediated ferritinophagy in cells and in an iron-dependent physiological setting.	Iron	170-174	nuclear receptor coactivator 4	Danio rerio	46-51
26436293-7	2015	This work reveals the molecular nature of the NCOA4-ferritin complex and explains how intracellular iron levels modulate NCOA4-mediated ferritinophagy in cells and in an iron-dependent physiological setting.	Iron	170-174	nuclear receptor coactivator 4	Danio rerio	121-126
27137899-5	2016	Novel structural insights into how FPN transports iron have been an important addition to the field, as has the recognition that some zinc transporters such as ZIP14 can transport iron.	Iron	50-54	solute carrier family 39 member 14	Homo sapiens	160-165
27376881-5	2017	In contrast to the upregulation of the nonreductive iron uptake genes ARN1 and FIT2 by ALA, the quantity of FET3 and FTR1 transcripts encoding the high-affinity iron uptake reductive pathway decreased.	Iron	161-165	ferroxidase FET3	Saccharomyces cerevisiae S288C	108-112
27137899-5	2016	Novel structural insights into how FPN transports iron have been an important addition to the field, as has the recognition that some zinc transporters such as ZIP14 can transport iron.	Iron	180-184	solute carrier family 39 member 14	Homo sapiens	160-165
26870796-2	2015	We used a tissue-specific conditional knockout strategy to ask whether skeletal muscle required Tfr1 for iron uptake.	Iron	105-109	transferrin receptor	Mus musculus	96-100
26870796-3	2015	We found that iron assimilation via Tfr1 was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver.	Iron	14-18	transferrin receptor	Mus musculus	36-40
27029487-2	2016	Homozygous mutations in the frataxine (FXN) gene reduce expression of frataxin and cause accumulation of iron in the mitochondria.	Iron	105-109	frataxin	Homo sapiens	28-36
27545647-4	2017	Methods and results: Iron content in cardiomyocytes was reduced in Irp-targeted mice.	Iron	21-25	wingless-type MMTV integration site family, member 2	Mus musculus	67-70
27498743-7	2016	In the liver, TFR2 forms a complex with HFE, a hereditary hemochromatosis-associated protein, and acts as an iron sensor.	Iron	109-113	homeostatic iron regulator	Homo sapiens	40-43
26047483-5	2015	We propose pathways for supplying iron to the lung in iron deficiency and for protecting the lung against iron excess in iron overload, mediated by the co-ordinated action of iron proteins, such as divalent metal transporter 1, ZRT-IRE-like-protein 14, transferrin receptor, ferritin, haemochromatosis-associated protein and ferroportin.	Iron	34-38	transferrin receptor	Mus musculus	253-273
26047483-13	2015	Divalent metal transporter 1 and TfR increased in iron deficiency, without changes in iron overload.	Iron	50-54	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-28
26047483-13	2015	Divalent metal transporter 1 and TfR increased in iron deficiency, without changes in iron overload.	Iron	50-54	transferrin receptor	Mus musculus	33-36
26047483-14	2015	ZRT-IRE-like protein 14 decreased in airway cells in iron deficiency and increased in iron overload.	Iron	53-57	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-23
27545647-8	2017	Mechanistically, the activity of the iron-sulphur cluster-containing complex I of the mitochondrial electron transport chain was reduced in left ventricles from Irp-targeted mice.	Iron	37-41	wingless-type MMTV integration site family, member 2	Mus musculus	161-164
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	75-79	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	124-128
27409114-4	2016	But the iron powders of MRF fluid are easily embedded into the soft surface of KDP crystal, which will greatly decrease the laser-induced damage resistance.	Iron	8-12	WNK lysine deficient protein kinase 1	Homo sapiens	79-82
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	75-79	transferrin receptor	Mus musculus	133-136
27545647-12	2017	As shown by electrophoretic mobility shift assays, IRP activity was significantly reduced in LV tissue samples from patients with advanced HF and reduced LV tissue iron content.	Iron	164-168	Wnt family member 2	Homo sapiens	51-54
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	75-79	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	295-299
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	75-79	solute carrier family 39 (zinc transporter), member 14	Mus musculus	301-306
27982729-5	2017	We observed 20 Bonferroni significant (P-value &lt; 9.4x 10-9) CpGs for Fe, 8 for Ni, and 1 for V. Particularly, methylation at Schlafen Family Member 11 (SLFN11) cg10911913 was positively associated with measured levels of all 3 species.	Iron	72-74	schlafen family member 11	Homo sapiens	128-153
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	83-87	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	124-128
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	83-87	transferrin receptor	Mus musculus	133-136
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	83-87	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	124-128
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	83-87	transferrin receptor	Mus musculus	133-136
27142998-3	2016	The FE properties of ZnO NWAs were effectively tuned by controlling the amount of Ag2S QDs.	Iron	4-6	angiotensin II receptor type 1	Homo sapiens	82-86
27982729-5	2017	We observed 20 Bonferroni significant (P-value &lt; 9.4x 10-9) CpGs for Fe, 8 for Ni, and 1 for V. Particularly, methylation at Schlafen Family Member 11 (SLFN11) cg10911913 was positively associated with measured levels of all 3 species.	Iron	72-74	schlafen family member 11	Homo sapiens	155-161
26412289-0	2015	Iron Deprivation May Enhance Insulin Receptor and Glut4 Transcription in Skeletal Muscle of Adult Rats.	Iron	0-4	insulin receptor	Rattus norvegicus	29-45
26929142-5	2017	ILR3 has been shown to regulate NEET in Arabidopsis, a critical protein in plant development, senescence, iron metabolism and reactive oxygen species (ROS) homeostasis.	Iron	106-110	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-4
26412289-8	2015	In addition, dietary iron restriction resulted in a twofold increase in mRNA expression of Insr and fourfold increase in Glut4 expression in skeletal muscle.	Iron	21-25	insulin receptor	Rattus norvegicus	91-95
26412289-12	2015	CONCLUSION: Dietary iron deprivation may improve insulin receptor and glucose transporter transcription in muscle; however, our results show that dietary iron restriction can prevent and/or promote oxidative damage in a tissue-specific manner, emphasizing the importance of maintaining optimal iron intake.	Iron	20-24	insulin receptor	Rattus norvegicus	49-65
27755990-8	2017	CONCLUSIONS: ALA could up-regulate TfR1, DMT1 and ferritin expression when iron is increased outside of the cell, promoting iron deposition into ferritin by increasing cell iron uptake, and then reducing free iron both inside and outside of the cell.	Iron	75-79	transferrin receptor	Mus musculus	35-39
26168137-5	2015	The ppt1 strains of all species were also reduced in tolerance to oxidative stress and iron depletion; both phenotypes are associated with inability to produce extracellular siderophores biosynthesized by the nonribosomal peptide synthetase Nps6.	Iron	87-91	plastid phosphate/phosphoenolpyruvate translocator 1	Zea mays	4-8
27755990-8	2017	CONCLUSIONS: ALA could up-regulate TfR1, DMT1 and ferritin expression when iron is increased outside of the cell, promoting iron deposition into ferritin by increasing cell iron uptake, and then reducing free iron both inside and outside of the cell.	Iron	75-79	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	41-45
26324903-1	2015	Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin.	Iron	51-55	transferrin receptor	Mus musculus	0-22
28005345-2	2017	The ligand reacted with Fe(ClO4)2 6H2O or Fe(ClO4)3 6H2O in the presence of tetrabutylammonium perchlorate, and Et3N under air and provided a mu2 oxo-bridged dinuclear iron complex (1).	Iron	168-172	adaptor related protein complex 1 subunit mu 2	Homo sapiens	142-145
26324903-1	2015	Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin.	Iron	51-55	transferrin receptor	Mus musculus	24-28
26324903-1	2015	Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin.	Iron	104-108	transferrin receptor	Mus musculus	0-22
26324903-1	2015	Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin.	Iron	104-108	transferrin receptor	Mus musculus	24-28
28133557-1	2017	Iron may accumulate in excess due to a mutation in the HFE gene that upregulates absorption or when it is ingested or infused at levels that exceed the body"s ability to clear it.	Iron	0-4	homeostatic iron regulator	Homo sapiens	55-58
26324903-7	2015	Surprisingly, however, enforced expression of a mutant allele of Tfr1 that is unable to serve as a receptor for iron-loaded transferrin appeared to fully rescue most animals.	Iron	112-116	transferrin receptor	Mus musculus	65-69
26324903-8	2015	Our results implicate Tfr1 in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function.	Iron	133-137	transferrin receptor	Mus musculus	22-26
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-65	NFS1 cysteine desulfurase	Homo sapiens	326-330
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-65	frataxin	Homo sapiens	451-459
26288007-5	2015	For M-rich phases the iron diffusion is hampered so that a significant fraction of superparamagnetic alpha-Fe2O3 particles (100% for BaFe(0.5-x)Co(1.5)(PO4)2) was detected even at 78 K. Although Ni(2+) and Co(2+) ions tend to block Fe diffusion, the crystal structure of BaFe(0.67)Co1(PO4)2 demonstrates a fully ordered rearrangement of Fe(3+) and Co(2+) ions after Fe exsolution.	Iron	107-109	ERC2 intronic transcript 1	Homo sapiens	152-157
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-65	frataxin	Homo sapiens	474-477
26288007-5	2015	For M-rich phases the iron diffusion is hampered so that a significant fraction of superparamagnetic alpha-Fe2O3 particles (100% for BaFe(0.5-x)Co(1.5)(PO4)2) was detected even at 78 K. Although Ni(2+) and Co(2+) ions tend to block Fe diffusion, the crystal structure of BaFe(0.67)Co1(PO4)2 demonstrates a fully ordered rearrangement of Fe(3+) and Co(2+) ions after Fe exsolution.	Iron	135-137	ERC2 intronic transcript 1	Homo sapiens	152-157
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-63	NFS1 cysteine desulfurase	Homo sapiens	326-330
28882199-3	2017	Early studies in yeast and human mitochondria indicated that Fe-S cluster assembly in eukaryotes is centered around highly conserved Fe-S proteins (human ISCU) that serve as scaffolds upon which new Fe-S clusters are assembled from (i) elemental sulfur, provided by a pyridoxal phosphate-dependent cysteine desulfurase (human NFS1) and its stabilizing-binding partner (human ISD11), and (ii) elemental iron, provided by an iron-binding protein of the frataxin family (human FXN).	Iron	61-63	frataxin	Homo sapiens	451-459
27812575-1	2016	This study evaluated the effect of chia on the iron bioavailability and gene expression of proteins involved in iron metabolism in animals fed with a high fat diet and a standard diet.	Iron	47-51	chitinase, acidic	Rattus norvegicus	35-39
25688831-0	2015	Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron-sulfur cluster assembly.	Iron	125-129	ferredoxin reductase	Homo sapiens	42-67
25688831-0	2015	Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron-sulfur cluster assembly.	Iron	125-129	NFS1 cysteine desulfurase	Homo sapiens	96-100
27812575-1	2016	This study evaluated the effect of chia on the iron bioavailability and gene expression of proteins involved in iron metabolism in animals fed with a high fat diet and a standard diet.	Iron	112-116	chitinase, acidic	Rattus norvegicus	35-39
27812575-9	2016	Animals fed with chia showed similar iron bioavailability compared to animals fed with ferrous sulfate.	Iron	37-41	chitinase, acidic	Rattus norvegicus	17-21
27518069-7	2016	Our results show that rare HFE variants are identified more frequently than variants in the other genes associated with iron overload.	Iron	120-124	homeostatic iron regulator	Homo sapiens	27-30
25853903-1	2015	Lipocalin-2 (LCN2) is a siderophore-binding protein involved in cellular iron transport and neuroinflammation.	Iron	73-77	lipocalin 2	Mus musculus	0-11
25853903-1	2015	Lipocalin-2 (LCN2) is a siderophore-binding protein involved in cellular iron transport and neuroinflammation.	Iron	73-77	lipocalin 2	Mus musculus	13-17
25853903-6	2015	In WT mice, brain LCN2 levels were increased in the ipsilateral basal ganglia after ICH or iron injection.	Iron	91-95	lipocalin 2	Mus musculus	18-22
26116529-10	2015	RGS19 was co-purified with iron and showed unique UV-absorption characteristics frequently observed in iron-binding proteins.	Iron	27-31	regulator of G protein signaling 19	Homo sapiens	0-5
27553379-0	2016	The impact of H63D HFE gene carriage on hemoglobin and iron status in children.	Iron	55-59	homeostatic iron regulator	Homo sapiens	19-22
26116529-10	2015	RGS19 was co-purified with iron and showed unique UV-absorption characteristics frequently observed in iron-binding proteins.	Iron	103-107	regulator of G protein signaling 19	Homo sapiens	0-5
26116529-11	2015	This study demonstrates that RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal.	Iron	51-55	regulator of G protein signaling 19	Homo sapiens	29-34
26116529-11	2015	This study demonstrates that RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal.	Iron	93-97	regulator of G protein signaling 19	Homo sapiens	29-34
27553379-11	2016	In conclusion, this study demonstrates that changes in iron metabolism occur at a young age in HFE heterozygotes.	Iron	55-59	homeostatic iron regulator	Homo sapiens	95-98
27211273-7	2016	We describe cryptic splicing events in the HSCs of SF3B1-mutant MDS, and our data support a model in which NMD-induced downregulation of the iron exporter ABCB7 mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 underlies the increased mitochondrial iron accumulation found in MDS patients with RS.	Iron	141-145	splicing factor 3b subunit 1	Homo sapiens	51-56
26140704-2	2015	It shows fast response (within 1 min), high selectivity, and is ultrasensitive to detect Fe(3+) or Cr(3+) in aqueous solution and living cells (KSV values are calculated to be 3.6x10(4)  L mol(-1) for Fe(3+) and 1.9x10(4)  L mol(-1) for Cr(3+) ).	Iron	89-91	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	237-243
27211273-7	2016	We describe cryptic splicing events in the HSCs of SF3B1-mutant MDS, and our data support a model in which NMD-induced downregulation of the iron exporter ABCB7 mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 underlies the increased mitochondrial iron accumulation found in MDS patients with RS.	Iron	141-145	splicing factor 3b subunit 1	Homo sapiens	227-232
26051278-2	2015	In this study, we evaluated the effectiveness of two novel 8-OH-quinoline-based iron chelators, Q1 and Q4, to decrease mitochondrial iron accumulation and oxidative damage in cellular and animal models of PD.	Iron	80-84	histocompatibility 2, Q region locus 1	Mus musculus	96-105
27840125-7	2016	We found that the pre-incubation with N-Acetyl-l-Cysteine (a quinone reductase inducer) or Deferoxamine (an iron chelator) prevents the generation of ROS, restores the autophagy degradation of mHtt and preserves the cell viability in SH-SY5Y cells expressing the polyQ Htt and exposed to DA.	Iron	108-112	huntingtin	Homo sapiens	194-197
26051278-2	2015	In this study, we evaluated the effectiveness of two novel 8-OH-quinoline-based iron chelators, Q1 and Q4, to decrease mitochondrial iron accumulation and oxidative damage in cellular and animal models of PD.	Iron	133-137	histocompatibility 2, Q region locus 1	Mus musculus	96-105
27901468-0	2016	Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals.	Iron	31-35	frataxin	Homo sapiens	8-16
26032732-11	2015	Thus, our results suggest the role of Ld-frataxin as an iron binding/carrier protein for Fe-S cluster biogenesis that physically interacts with other core components of the ISC machinery within the mitochondria.	Iron	56-60	frataxin	Homo sapiens	41-49
26032732-11	2015	Thus, our results suggest the role of Ld-frataxin as an iron binding/carrier protein for Fe-S cluster biogenesis that physically interacts with other core components of the ISC machinery within the mitochondria.	Iron	89-93	frataxin	Homo sapiens	41-49
26047847-4	2015	In addition, in cells such as to erythroid precursors, following transferrin receptor (TfR) mediated endocytosis; it mediates H(+)-coupled exit of ferrous iron from endocytic vesicles into the cytosol.	Iron	147-159	transferrin receptor	Homo sapiens	65-85
26047847-4	2015	In addition, in cells such as to erythroid precursors, following transferrin receptor (TfR) mediated endocytosis; it mediates H(+)-coupled exit of ferrous iron from endocytic vesicles into the cytosol.	Iron	147-159	transferrin receptor	Homo sapiens	87-90
27901468-0	2016	Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals.	Iron	31-35	myocyte enhancer factor 2A	Homo sapiens	54-58
27901468-2	2016	Loss of FXN causes impaired mitochondrial function and iron homeostasis.	Iron	55-59	frataxin	Homo sapiens	8-11
27901468-5	2016	In fh mutants, iron accumulation in the nervous system enhances the synthesis of sphingolipids, which in turn activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2) to trigger neurodegeneration of adult photoreceptors.	Iron	15-19	myocyte enhancer factor 2A	Homo sapiens	177-202
27653419-6	2016	A bacterial Fe-S assembly complex, composed of the cysteine desulfurase IscS and scaffold protein IscU, was used to generate [2Fe-2S] clusters for transfer to mixtures of putative intermediate carrier and acceptor proteins.	Iron	12-16	NFS1 cysteine desulfurase	Homo sapiens	72-76
26142323-1	2015	Diagnostic genetic testing for hereditary hemochromatosis is readily available for clinically relevant HFE variants (i.e., those that generate the C282Y, H63D and S65C HFE polymorphisms); however, genetic testing for other known causes of iron overload, including mutations affecting genes encoding hemojuvelin, transferrin receptor 2, HAMP, and ferroportin is not.	Iron	239-243	homeostatic iron regulator	Homo sapiens	103-106
26002909-6	2015	Consistent with the function of FRD3 as a citrate efflux protein, the iron retention defect in gcn5 was rescued and fertility was partly restored by overexpressing FRD3.	Iron	70-74	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	95-99
27653419-7	2016	The focus of this study was to test whether the monothiol glutaredoxin, Grx4, functions as an obligate [2Fe-2S] carrier protein in the Fe-S cluster distribution network.	Iron	105-107	glutaredoxin	Homo sapiens	58-70
26002909-7	2015	Moreover, iron retention in gcn5 roots was significantly reduced by the exogenous application of citrate.	Iron	10-14	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	28-32
28175303-3	2016	FRDA neurons showed lower levels of iron-sulfur (Fe-S) and lipoic acid-containing proteins, higher labile iron pool (LIP), higher expression of mitochondrial superoxide dismutase (SOD2), increased reactive oxygen species (ROS) and lower reduced glutathione (GSH) levels, and enhanced sensitivity to oxidants compared with CT neurons, indicating deficient Fe-S cluster biogenesis, altered iron metabolism, and oxidative stress.	Iron	36-40	frataxin	Homo sapiens	0-4
28175303-3	2016	FRDA neurons showed lower levels of iron-sulfur (Fe-S) and lipoic acid-containing proteins, higher labile iron pool (LIP), higher expression of mitochondrial superoxide dismutase (SOD2), increased reactive oxygen species (ROS) and lower reduced glutathione (GSH) levels, and enhanced sensitivity to oxidants compared with CT neurons, indicating deficient Fe-S cluster biogenesis, altered iron metabolism, and oxidative stress.	Iron	49-53	frataxin	Homo sapiens	0-4
28162284-8	2015	However, two cytosolic proteins related to iron (Aco1) and one carbon (Mat2) metabolism decreased markedly.	Iron	43-47	aconitase 1	Homo sapiens	49-53
28175303-3	2016	FRDA neurons showed lower levels of iron-sulfur (Fe-S) and lipoic acid-containing proteins, higher labile iron pool (LIP), higher expression of mitochondrial superoxide dismutase (SOD2), increased reactive oxygen species (ROS) and lower reduced glutathione (GSH) levels, and enhanced sensitivity to oxidants compared with CT neurons, indicating deficient Fe-S cluster biogenesis, altered iron metabolism, and oxidative stress.	Iron	106-110	frataxin	Homo sapiens	0-4
27891139-12	2016	Finally, auxin inhibitor applied with higher Fe concentration caused a significant decline in morpho-physiological parameters along with increased TaSAMS and TaDMAS1 expression in roots of BR 27, revealing the involvement of auxin signaling in response to excess Fe.	Iron	45-47	S-adenosylmethionine synthase	Triticum aestivum	147-153
26061285-4	2015	The latter significant back donation opens a new channel for superexchange interactions that can enhance the FM coupling between Fe centers, where the strength of calculated intrachain FM coupling constrant (Jin) in O2 adsorbed Fe-MOF-74 is more than 10 times enhanced compared to bare Fe-MOF-74.	Iron	129-131	lysine acetyltransferase 8	Homo sapiens	231-234
27687674-4	2016	Molecular modeling studies showed that the 3-SH group of B19 is closer (3.36A) to the iron atom of the heme system than the 3-OH group of enzyme substrates estrone and estradiol (4.26A and 3.58A, respectively).	Iron	86-90	eva-1 homolog C	Homo sapiens	57-60
26061285-4	2015	The latter significant back donation opens a new channel for superexchange interactions that can enhance the FM coupling between Fe centers, where the strength of calculated intrachain FM coupling constrant (Jin) in O2 adsorbed Fe-MOF-74 is more than 10 times enhanced compared to bare Fe-MOF-74.	Iron	129-131	lysine acetyltransferase 8	Homo sapiens	289-292
25972160-5	2015	Hypothesizing that iron restriction improved her symptoms by decreasing ALAS2 activity and subsequent porphyrin production, we treated the patient with off-label use of deferasirox to maintain iron deficiency, with successful results.	Iron	19-23	5'-aminolevulinate synthase 2	Homo sapiens	72-77
26728570-3	2016	Inductively coupled plasma atomic emission spectroscopy demonstrated increased iron in the Hfe-/- x Tfr2mut brain (P=0.002, n &gt;=5/group), primarily localized by Perls" staining to myelinated structures.	Iron	79-83	homeostatic iron regulator	Homo sapiens	91-94
26028554-0	2015	SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis.	Iron	59-63	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-8
26028554-6	2015	Slc39a14 deficiency in hemochromatotic mice greatly diminished iron loading of the liver and prevented iron deposition in hepatocytes and pancreatic acinar cells.	Iron	63-67	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-8
26028554-6	2015	Slc39a14 deficiency in hemochromatotic mice greatly diminished iron loading of the liver and prevented iron deposition in hepatocytes and pancreatic acinar cells.	Iron	103-107	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-8
26028554-7	2015	The data suggest that inhibition of SLC39A14 may mitigate hepatic and pancreatic iron loading and associated pathologies in iron overload disorders.	Iron	81-85	solute carrier family 39 (zinc transporter), member 14	Mus musculus	36-44
26419445-3	2016	Transferrin receptor 1 (TfR1) plays a key role in cellular iron transport.	Iron	59-63	transferrin receptor	Mus musculus	0-22
26728570-6	2016	Overlap (P&lt;0.0001) of differentially expressed genes in Hfe-/- x Tfr2mut brain with human gene co-expression networks suggests iron loading influences expression of NBIA-related and myelin-related genes co-expressed in normal human basal ganglia.	Iron	130-134	homeostatic iron regulator	Homo sapiens	59-62
26419445-3	2016	Transferrin receptor 1 (TfR1) plays a key role in cellular iron transport.	Iron	59-63	transferrin receptor	Mus musculus	24-28
27796299-0	2016	Disposal of iron by a mutant form of lipocalin 2.	Iron	12-16	lipocalin 2	Mus musculus	37-48
27129098-0	2016	Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich"s ataxia.	Iron	54-58	frataxin	Homo sapiens	0-8
26070639-2	2015	FER, isolated from tomato (Solanum lycopersicum), was the first transcription factor involved in the iron homeostasis of higher plants to be identified.	Iron	101-105	bHLH transcriptional regulator	Solanum lycopersicum	0-3
26070639-3	2015	A FER defect in the T3238fer mutant drastically downregulates the expression of iron uptake genes, such as ferric-chelate reductase 1 (LeFRO1) and iron-regulated transporter 1 (LeIRT1); however, the molecular mechanism by which FER regulates genes downstream remains unknown.	Iron	80-84	bHLH transcriptional regulator	Solanum lycopersicum	2-5
26070639-3	2015	A FER defect in the T3238fer mutant drastically downregulates the expression of iron uptake genes, such as ferric-chelate reductase 1 (LeFRO1) and iron-regulated transporter 1 (LeIRT1); however, the molecular mechanism by which FER regulates genes downstream remains unknown.	Iron	80-84	ferric-chelate reductase	Solanum lycopersicum	135-141
26070639-3	2015	A FER defect in the T3238fer mutant drastically downregulates the expression of iron uptake genes, such as ferric-chelate reductase 1 (LeFRO1) and iron-regulated transporter 1 (LeIRT1); however, the molecular mechanism by which FER regulates genes downstream remains unknown.	Iron	80-84	bHLH transcriptional regulator	Solanum lycopersicum	228-231
27129098-2	2016	The enigmatic mitochondrial protein, frataxin, is known to play a significant role in both cellular and mitochondrial iron metabolism due to its iron-binding properties and its involvement in iron-sulfur cluster (ISC) and heme synthesis.	Iron	118-122	frataxin	Homo sapiens	37-45
27129098-2	2016	The enigmatic mitochondrial protein, frataxin, is known to play a significant role in both cellular and mitochondrial iron metabolism due to its iron-binding properties and its involvement in iron-sulfur cluster (ISC) and heme synthesis.	Iron	145-149	frataxin	Homo sapiens	37-45
27796299-5	2016	Mutant LCN2 strips iron from transferrin and citrate, and delivers it into the urine.	Iron	19-23	lipocalin 2	Mus musculus	7-11
27129098-2	2016	The enigmatic mitochondrial protein, frataxin, is known to play a significant role in both cellular and mitochondrial iron metabolism due to its iron-binding properties and its involvement in iron-sulfur cluster (ISC) and heme synthesis.	Iron	145-149	frataxin	Homo sapiens	37-45
27129098-3	2016	The inherited neuro- and cardio-degenerative disease, Friedreich"s ataxia (FA), is caused by the deficient expression of frataxin that leads to deleterious alterations in iron metabolism.	Iron	171-175	frataxin	Homo sapiens	121-129
27523281-4	2016	Here we report that epidermal growth factor receptor (EGFR), an oncogenic driver, binds to and regulates the subcellular distribution of transferrin receptor 1(TfR1) through its tyrosine kinase activity and thus is required for cellular iron import.	Iron	237-241	transferrin receptor	Homo sapiens	160-164
26837749-3	2016	We hypothesised that HOSCN, a thiol-specific oxidant may target the iron-sulphur cluster of aconitase (both isolated, and within primary human coronary artery endothelial cells; HCAEC) resulting in enzyme dysfunction, release of iron, and conversion of the cytosolic isoform to iron response protein-1, which regulates intracellular iron levels.	Iron	68-72	aconitase 1	Homo sapiens	278-301
25843914-6	2015	Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, such as the alternative splicing, microRNAs, the IRP/IRE system and the proteolytic cleavage.	Iron	60-64	Wnt family member 2	Homo sapiens	190-193
25656940-0	2015	Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats.	Iron	40-44	ceruloplasmin	Rattus norvegicus	0-13
27095402-4	2016	Lam induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast antioxidant system.	Iron	87-89	ZIP8	Arabidopsis thaliana	32-36
27523281-5	2016	Inactivation of EGFR reduces the cell surface TfR1 expression, which leads to decreased iron import due to impaired TfR1-mediated iron uptake.	Iron	88-92	transferrin receptor	Homo sapiens	46-50
27523281-5	2016	Inactivation of EGFR reduces the cell surface TfR1 expression, which leads to decreased iron import due to impaired TfR1-mediated iron uptake.	Iron	130-134	transferrin receptor	Homo sapiens	46-50
27523281-5	2016	Inactivation of EGFR reduces the cell surface TfR1 expression, which leads to decreased iron import due to impaired TfR1-mediated iron uptake.	Iron	130-134	transferrin receptor	Homo sapiens	116-120
27342530-14	2016	CONCLUSION: Iron overload can inhibit the ratio of CD8+ T cells of splenic cells in mice, decrease the expression of IFN-gamma, Granzyme-B, increase the apoptosis of CD3+ CD8+/CD8-.	Iron	12-16	granzyme B	Mus musculus	128-138
27342530-14	2016	CONCLUSION: Iron overload can inhibit the ratio of CD8+ T cells of splenic cells in mice, decrease the expression of IFN-gamma, Granzyme-B, increase the apoptosis of CD3+ CD8+/CD8-.	Iron	12-16	CD3 antigen, epsilon polypeptide	Mus musculus	166-169
25737209-3	2015	The classical model of iron metabolism with iron response element/iron response protein (IRE/IRP) is now extended to include hepcidin model.	Iron	23-27	Wnt family member 2	Homo sapiens	93-96
25737209-3	2015	The classical model of iron metabolism with iron response element/iron response protein (IRE/IRP) is now extended to include hepcidin model.	Iron	44-48	Wnt family member 2	Homo sapiens	93-96
25737209-3	2015	The classical model of iron metabolism with iron response element/iron response protein (IRE/IRP) is now extended to include hepcidin model.	Iron	44-48	Wnt family member 2	Homo sapiens	93-96
27523281-8	2016	Our findings uncover a new role of EGFR in modulating cellular iron homeostasis through redistribution of TfR1, which is essential for cancer development and progression.	Iron	63-67	transferrin receptor	Homo sapiens	106-110
27991963-0	2016	Iron restriction increases myoglobin gene and protein expression in Soleus muscle of rats.	Iron	0-4	myoglobin	Rattus norvegicus	27-36
27101081-1	2016	Orientations of the FA and FB iron-sulfur (FeS) clusters in a structure-unknown type-I homodimeric heriobacterial reaction center (hRC) were studied in oriented membranes of the thermophilic anaerobic photosynthetic bacterium Heliobacterium modesticaldum by electron paramagnetic resonance (EPR), and compared with those in heterodimeric photosystem I (PS I).	Iron	43-46	histidine rich calcium binding protein	Homo sapiens	131-134
27991963-7	2016	The aim of this study was to investigate whether iron supplementation or long and short-term restriction affects Mb gene and protein expression, as well as Mb mRNA poly(A) tail length, in cardiac and skeletal muscles of rats.	Iron	49-53	myoglobin	Rattus norvegicus	113-115
27991963-8	2016	Long-term iron restriction caused an increase in Mb gene and protein expression in Soleus muscle.	Iron	10-14	myoglobin	Rattus norvegicus	49-51
26911281-7	2016	Instead, the sex-determining region Y (SRY)-box 9 protein (SOX9) was substantially linked to iron treatment and hydroxyl radical level.	Iron	93-97	SRY-box transcription factor 9	Homo sapiens	59-63
27991963-11	2016	These results indicate that Mb gene and protein expression is upregulated in response to iron deprivation, an effect that is tissue-specific and seems to occur at transcriptional level.	Iron	89-93	myoglobin	Rattus norvegicus	28-30
26911281-8	2016	Using gene manipulations, including ectopic SOX9 overexpression and SOX9 short hairpin RNA knockdown, we have verified that SOX9 is responsible for CSC enrichment mediated by iron.	Iron	175-179	SRY-box transcription factor 9	Homo sapiens	68-72
26911281-8	2016	Using gene manipulations, including ectopic SOX9 overexpression and SOX9 short hairpin RNA knockdown, we have verified that SOX9 is responsible for CSC enrichment mediated by iron.	Iron	175-179	SRY-box transcription factor 9	Homo sapiens	68-72
27599775-9	2016	The expression augmentation of PKM2 during hypoxia was greater upon low iron compared with that of ferric salt treatment (P&lt;0.01).	Iron	72-76	pyruvate kinase M1/2	Rattus norvegicus	31-35
26911281-9	2016	These findings indicate a novel role of iron via hydroxyl radical in CSC regulation and its importance in aggressive cancer behaviors and likely metastasis through SOX9 upregulation.	Iron	40-44	SRY-box transcription factor 9	Homo sapiens	164-168
27604527-1	2016	Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of which is subsequently converted to bilirubin.	Iron	126-138	heme oxygenase 2	Homo sapiens	56-61
26474245-1	2016	BACKGROUND &amp; AIMS: Iron overload (IO) in HFE-related hereditary haemochromatosis is associated with increased risk of liver cancer.	Iron	23-27	homeostatic iron regulator	Homo sapiens	45-48
26970172-10	2016	CONCLUSION: MDS-RS patients carrying SF3B1 mutations harbored a more severe iron overload and corresponding over-erythropoiesis.	Iron	76-80	splicing factor 3b subunit 1	Homo sapiens	37-42
27519411-2	2016	As the architecture of the human machinery remains undefined, we co-expressed in Escherichia coli the following four proteins involved in the initial step of Fe-S cluster synthesis: FXN42-210 (iron donor); [NFS1] [ISD11] (sulfur donor); and ISCU (scaffold upon which new clusters are assembled).	Iron	158-162	NFS1 cysteine desulfurase	Homo sapiens	207-211
26966178-2	2016	Here we show that respiratory growth of and iron acquisition by the yeast Saccharomyces cerevisiae relies on potassium (K(+)) compartmentalization to the trans-Golgi network via Kha1p, a K(+)/H(+) exchanger.	Iron	44-48	Kha1p	Saccharomyces cerevisiae S288C	178-183
26966178-6	2016	Up-regulation of KHA1 gene in response to iron limitation via iron-specific transcription factors indicates that K(+) compartmentalization is linked to cellular iron homeostasis.	Iron	42-46	Kha1p	Saccharomyces cerevisiae S288C	17-21
26966178-6	2016	Up-regulation of KHA1 gene in response to iron limitation via iron-specific transcription factors indicates that K(+) compartmentalization is linked to cellular iron homeostasis.	Iron	62-66	Kha1p	Saccharomyces cerevisiae S288C	17-21
26966178-6	2016	Up-regulation of KHA1 gene in response to iron limitation via iron-specific transcription factors indicates that K(+) compartmentalization is linked to cellular iron homeostasis.	Iron	62-66	Kha1p	Saccharomyces cerevisiae S288C	17-21
27519411-8	2016	Binding of 12 [NFS1]2 [ISD11]2 sub-complexes to the surface results in a globular macromolecule with a diameter of ~15 nm and creates 24 Fe-S cluster assembly centers.	Iron	137-141	NFS1 cysteine desulfurase	Homo sapiens	15-19
27546461-0	2016	Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.	Iron	0-4	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	16-20
27046064-3	2016	A Tafel slope of 34 mV dec(-1) was obtained for Fe-Ci, which is lower than other reported values for iron-based catalysts.	Iron	101-105	deleted in esophageal cancer 1	Homo sapiens	23-29
27546461-2	2016	Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2alpha-dependent transcription.	Iron	70-74	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	85-113
27077775-1	2016	OBJECTIVES: The recent availability of potent oral iron chelators is renewing an interest in the assessment of the possible impact of HFE genetics in MDS.	Iron	51-55	homeostatic iron regulator	Homo sapiens	134-137
27546461-2	2016	Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2alpha-dependent transcription.	Iron	70-74	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	115-119
27077775-12	2016	It remains a challenging question if HFE mutated MDS patients should be considered for potent iron chelation therapy.	Iron	94-98	homeostatic iron regulator	Homo sapiens	37-40
27546461-4	2016	Proteomic and genomic analyses identified an iron-regulated signaling axis mediated by cyclin-dependent kinase 1 (CDK1), JAK1, and STAT3 in CRC progression.	Iron	45-49	cyclin-dependent kinase 1	Mus musculus	87-112
27546461-4	2016	Proteomic and genomic analyses identified an iron-regulated signaling axis mediated by cyclin-dependent kinase 1 (CDK1), JAK1, and STAT3 in CRC progression.	Iron	45-49	cyclin-dependent kinase 1	Mus musculus	114-118
26887944-2	2016	Recently, mNT has been implicated in cytosolic Fe-S repair of a key regulator of cellular iron homeostasis.	Iron	47-51	max binding protein	Mus musculus	10-13
27546461-4	2016	Proteomic and genomic analyses identified an iron-regulated signaling axis mediated by cyclin-dependent kinase 1 (CDK1), JAK1, and STAT3 in CRC progression.	Iron	45-49	Janus kinase 1	Mus musculus	121-125
26887944-2	2016	Recently, mNT has been implicated in cytosolic Fe-S repair of a key regulator of cellular iron homeostasis.	Iron	90-94	max binding protein	Mus musculus	10-13
27546461-5	2016	A pharmacological inhibitor of DMT1 antagonized the ability of iron to promote tumor growth in a CRC mouse model and a patient-derived CRC enteroid orthotopic model.	Iron	63-67	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	31-35
26887944-3	2016	Here, we aimed to decipher the mechanism by which mNT triggers its Fe-S repair capacity.	Iron	67-71	max binding protein	Mus musculus	50-53
26887944-8	2016	Our findings thus demonstrate that mNT uses an iron-based redox switch mechanism to regulate the transfer of its cluster.	Iron	47-51	max binding protein	Mus musculus	35-38
26887944-10	2016	Finally, we propose that the redox-sensing function of mNT is a key component of the cellular adaptive response to help stress-sensitive Fe-S proteins recover from oxidative injury.	Iron	137-141	max binding protein	Mus musculus	55-58
29964783-1	2016	Zero-Valent Iron Permeable Reactive Barrier (Fe0-PRB) is a competitive and economical in-situ groundwater remediation technology in recent years, and high removal efficiencies of Cr(VI)-polluted groundwater have been realized.	Iron	12-16	RB transcriptional corepressor 1	Homo sapiens	49-52
26869387-3	2016	LCN2 is involved in cellular iron transport and neuroinflammation.	Iron	29-33	lipocalin 2	Mus musculus	0-4
27255319-2	2016	In that purpose, TiO2-iron-exchanged zeolite (FeZ) composite was prepared using commercial Aeroxide TiO2 P25 and iron-exchanged zeolite of ZSM5 type, FeZ.	Iron	113-117	FEZ family zinc finger 1	Homo sapiens	46-49
27240804-20	2016	Based on our model, we found that exacerbations and iron binding capacity (UIBC) were predictive factors for RLS/WED (p &lt; 0.100) CONCLUSION: RLS/WED is a common disease in cases with stable COPD.	Iron	52-56	COPD	Homo sapiens	193-197
26805042-3	2016	Human (h)MBLf enzymes can bind metals, including zinc and iron ions, and catalyze a range of chemically interesting reactions, including both redox (e.g., ETHE1) and hydrolytic processes (e.g., Glyoxalase II, SNM1 nucleases, and CPSF73).	Iron	58-62	ETHE1 persulfide dioxygenase	Homo sapiens	155-160
26919691-5	2016	Insertion of the iron center signals to the metallochaperones HypA, HypB, and SlyD to selectively deliver the nickel to the active site.	Iron	17-21	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	68-72
27329933-8	2016	Injection of myoglobin to the rat results in impairment of renal functioning and inhibition of myoglobin degradation in the rhabdomyolytic animal aggravates acute renal failure, demonstrating that degradation of myoglobin is somehow beneficial although it may result in undesired release of free iron which can participate in toxic redox cycling.	Iron	296-300	myoglobin	Rattus norvegicus	13-22
26537310-1	2016	Hemochromatosis factor E (HFE) is a member of class I MHC family and plays a significant role in the iron homeostasis.	Iron	101-105	homeostatic iron regulator	Homo sapiens	0-24
26537310-1	2016	Hemochromatosis factor E (HFE) is a member of class I MHC family and plays a significant role in the iron homeostasis.	Iron	101-105	homeostatic iron regulator	Homo sapiens	26-29
27537180-10	2016	Furthermore, higher copper levels in the HFe diet increased serum nonheme iron concentration and transferrin saturation, exacerbated hepatic nonheme iron loading and attenuated splenic nonheme iron accumulation.	Iron	149-153	homeostatic iron regulator	Rattus norvegicus	41-44
27537180-10	2016	Furthermore, higher copper levels in the HFe diet increased serum nonheme iron concentration and transferrin saturation, exacerbated hepatic nonheme iron loading and attenuated splenic nonheme iron accumulation.	Iron	149-153	homeostatic iron regulator	Rattus norvegicus	41-44
26684058-10	2016	Multivariate logistic regression analyses showed that increased levels of soluble transferrin receptor indicating abnormal iron status were independently associated with advanced New York Heart Association class (P &lt; .05).	Iron	123-127	transferrin receptor	Homo sapiens	82-102
27233612-0	2016	ELS1, a novel MATE transporter related to leaf senescence and iron homeostasis in Arabidopsis thaliana.	Iron	62-66	UB-like protease 1A	Arabidopsis thaliana	0-4
26768209-7	2016	The intracranial CD91-hemopexin system was active after SAH because CD91 positively correlated with iron deposition in brain tissue.	Iron	100-104	hemopexin	Homo sapiens	22-31
27233612-5	2016	Further investigations revealed that the overexpression of ELS1 reduces iron content in els1-D, and the accelerated senescence of the detached els1-D leaves can be recovered by exogenous iron supply.	Iron	72-76	UB-like protease 1A	Arabidopsis thaliana	59-63
27233612-5	2016	Further investigations revealed that the overexpression of ELS1 reduces iron content in els1-D, and the accelerated senescence of the detached els1-D leaves can be recovered by exogenous iron supply.	Iron	72-76	UB-like protease 1A	Arabidopsis thaliana	88-92
27233612-5	2016	Further investigations revealed that the overexpression of ELS1 reduces iron content in els1-D, and the accelerated senescence of the detached els1-D leaves can be recovered by exogenous iron supply.	Iron	187-191	UB-like protease 1A	Arabidopsis thaliana	59-63
27233612-5	2016	Further investigations revealed that the overexpression of ELS1 reduces iron content in els1-D, and the accelerated senescence of the detached els1-D leaves can be recovered by exogenous iron supply.	Iron	187-191	UB-like protease 1A	Arabidopsis thaliana	143-147
30042956-6	2016	Further, flow cytometric analysis confirmed the presence of iron-labeled CD19+ B cells, CD3+ T cells, and CD11b + myeloid cells within the spleen and the bone marrow.	Iron	60-64	CD19 molecule	Homo sapiens	73-77
27233612-6	2016	In addition, we also found that ELS1 is an iron responsive gene.	Iron	43-47	UB-like protease 1A	Arabidopsis thaliana	32-36
30090406-3	2016	ZIP8 also mediates the cellular uptake of divalent metal ions including iron, manganese, and the toxic heavy metal cadmium.	Iron	72-76	solute carrier family 39 member 8	Homo sapiens	0-4
27233612-7	2016	Based on these findings, we proposed that ELS1 is related to leaf senescence and iron homeostasis in Arabidopsis.	Iron	81-85	UB-like protease 1A	Arabidopsis thaliana	42-46
27178558-1	2016	In this work, polyethyleneimine grafted silica-coated nanoscale zero valent iron (Fe@SiO2@PEI) has been successfully synthesized and was investigated to be an effective adsorbent for efficient enrichment of five phthalate esters such as diphenyl phthalate, dibenzyl phthalate, butyl benzyl phthalate, diphenyl isophthalate, and dicyclohexyl phthalate (DPP, DBP, BBP, DPIP, and DCHP) from environmental water samples.	Iron	76-80	transmembrane protein 158	Homo sapiens	362-365
26821380-3	2016	The current treatment for SLC25A38 congenital sideroblastic anemia is chronic blood transfusion coupled with iron chelation.	Iron	109-113	solute carrier family 25 member 38	Homo sapiens	26-34
27178558-1	2016	In this work, polyethyleneimine grafted silica-coated nanoscale zero valent iron (Fe@SiO2@PEI) has been successfully synthesized and was investigated to be an effective adsorbent for efficient enrichment of five phthalate esters such as diphenyl phthalate, dibenzyl phthalate, butyl benzyl phthalate, diphenyl isophthalate, and dicyclohexyl phthalate (DPP, DBP, BBP, DPIP, and DCHP) from environmental water samples.	Iron	82-84	transmembrane protein 158	Homo sapiens	362-365
27216871-3	2016	TPO activity is iron (Fe)-dependent and dietary iron deficiency (FeD) also reduces circulating levels of TH.	Iron	16-20	thyroid peroxidase	Rattus norvegicus	0-3
26448492-4	2016	The results suggest that the developed method could obtain high COD removal (65.1%) and BOD5/COD ratio (0.26) due to the synergistic reaction between Fe/Cu/air and Fenton.	Iron	150-152	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	64-67
26448492-4	2016	The results suggest that the developed method could obtain high COD removal (65.1%) and BOD5/COD ratio (0.26) due to the synergistic reaction between Fe/Cu/air and Fenton.	Iron	150-152	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	93-96
25050519-8	2015	Nitrotyrosine and caspase 3 levels were shown to correlate positively with the amount of Prussian blue-detectable iron(III) deposits in iron dextran- and iron isomaltoside 1000-treated rats but not in ferumoxytol-treated rats, suggesting that iron dextran, iron isomaltoside 1000 and ferumoxytol induce nitrosative (and oxidative) stress as well as apoptosis via different mechanism(s).	Iron	114-118	caspase 3	Rattus norvegicus	18-27
27216871-3	2016	TPO activity is iron (Fe)-dependent and dietary iron deficiency (FeD) also reduces circulating levels of TH.	Iron	22-24	thyroid peroxidase	Rattus norvegicus	0-3
27061370-1	2016	TaNAM transcription factors play an important role in controlling senescence, which in turn, influences the delivery of nitrogen, iron and other elements to the grain of wheat (Triticum aestivum) plants, thus contributing to grain nutritional value.	Iron	130-134	NAC domain-containing protein 20	Triticum aestivum	0-5
25862412-3	2015	Thus, absence of PrP(C) in PrP-knock-out (PrP(-/-)) mice resulted in markedly reduced liver iron stores, a deficiency that was not corrected by chronic or acute administration of iron by the oral or intraperitoneal routes.	Iron	92-96	prion protein	Mus musculus	17-23
25862412-3	2015	Thus, absence of PrP(C) in PrP-knock-out (PrP(-/-)) mice resulted in markedly reduced liver iron stores, a deficiency that was not corrected by chronic or acute administration of iron by the oral or intraperitoneal routes.	Iron	92-96	prion protein	Mus musculus	17-20
25862412-5	2015	However, uptake, storage, and utilization of ferritin-bound iron that does not require reduction for uptake were increased in PrP(-/-) mice, indicating a compensatory response to the iron deficiency.	Iron	60-64	prion protein	Mus musculus	126-129
26213099-4	2016	For the later transition metals Fe, Co, and Ni, the lowest energy (C10H8)2 M2 structures contain pentahapto-trihapto azulene ligands with an uncomplexed C=C double bond, similar to that in the long-known iron carbonyl complex (eta(5),eta(3)-C10H8)Fe2 (CO)5 .	Iron	32-34	endothelin receptor type A	Homo sapiens	26-29
28959462-2	2016	The current study investigated the role of lipocalin 2 (LCN2), a protein involved in iron handling, in the ventricular dilation and neuroinflammation caused by brain injury in a mouse model of IVH.	Iron	85-89	lipocalin 2	Mus musculus	43-54
26625322-0	2016	Efficient attenuation of Friedreich"s ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA.	Iron	84-88	frataxin	Homo sapiens	46-50
26625322-1	2016	BACKGROUND: Friedreich"s ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is caused by silencing of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	230-234	frataxin	Homo sapiens	33-37
26625322-1	2016	BACKGROUND: Friedreich"s ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is caused by silencing of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	230-234	frataxin	Homo sapiens	163-171
26625322-1	2016	BACKGROUND: Friedreich"s ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is caused by silencing of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	230-234	frataxin	Homo sapiens	173-176
26625322-5	2016	Further mechanistic studies revealed that DFP also modulated iron induced mitochondrial stress as reflected by mitochondria network disorganization and decline level of respiratory chain protein, succinate dehydrogenase (CxII) and cytochrome c oxidase (COXIV).	Iron	61-65	cytochrome c oxidase subunit 4I1	Homo sapiens	253-258
25929520-1	2015	It is generally accepted that Friedreich"s ataxia (FRDA) is caused by a deficiency in frataxin expression, a mitochondrial protein involved in iron homeostasis, which mainly affects the brain, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas.	Iron	143-147	frataxin	Homo sapiens	51-55
25929520-1	2015	It is generally accepted that Friedreich"s ataxia (FRDA) is caused by a deficiency in frataxin expression, a mitochondrial protein involved in iron homeostasis, which mainly affects the brain, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas.	Iron	143-147	frataxin	Homo sapiens	86-94
25929520-11	2015	In conclusion, our data show that FRDA cells present altered expression of genes related to cell cycle, oxidative stress and iron homeostasis which may be implicated in the increased apoptotic levels.	Iron	125-129	frataxin	Homo sapiens	34-38
26024779-8	2015	Molecular analysis revealed that HFE variant allele (G) (rs1799945) was significantly associated with an adequate response to iron supplementation.	Iron	126-130	homeostatic iron regulator	Homo sapiens	33-36
26625322-6	2016	In addition, iron-response protein (IRP-1) regulatory loop was overridden by DFP as reflected by resumed level of ferritin (FTH) back to basal level and the attenuated transferrin receptor (TSFR) mRNA level suppression thereby reducing further iron uptake.	Iron	13-17	aconitase 1	Homo sapiens	36-41
26625322-6	2016	In addition, iron-response protein (IRP-1) regulatory loop was overridden by DFP as reflected by resumed level of ferritin (FTH) back to basal level and the attenuated transferrin receptor (TSFR) mRNA level suppression thereby reducing further iron uptake.	Iron	13-17	transferrin receptor	Homo sapiens	168-188
26625322-6	2016	In addition, iron-response protein (IRP-1) regulatory loop was overridden by DFP as reflected by resumed level of ferritin (FTH) back to basal level and the attenuated transferrin receptor (TSFR) mRNA level suppression thereby reducing further iron uptake.	Iron	13-17	transferrin receptor	Homo sapiens	190-194
26625322-6	2016	In addition, iron-response protein (IRP-1) regulatory loop was overridden by DFP as reflected by resumed level of ferritin (FTH) back to basal level and the attenuated transferrin receptor (TSFR) mRNA level suppression thereby reducing further iron uptake.	Iron	244-248	aconitase 1	Homo sapiens	36-41
25891893-3	2015	Transferrin receptor 1 (TfR1) controls the rate of cellular iron uptake by tuning the amount of iron delivered to the cells to meet metabolic needs.	Iron	60-64	transferrin receptor	Homo sapiens	24-28
28959462-2	2016	The current study investigated the role of lipocalin 2 (LCN2), a protein involved in iron handling, in the ventricular dilation and neuroinflammation caused by brain injury in a mouse model of IVH.	Iron	85-89	lipocalin 2	Mus musculus	56-60
25891893-3	2015	Transferrin receptor 1 (TfR1) controls the rate of cellular iron uptake by tuning the amount of iron delivered to the cells to meet metabolic needs.	Iron	96-100	transferrin receptor	Homo sapiens	0-22
25891893-3	2015	Transferrin receptor 1 (TfR1) controls the rate of cellular iron uptake by tuning the amount of iron delivered to the cells to meet metabolic needs.	Iron	96-100	transferrin receptor	Homo sapiens	24-28
26463963-3	2016	Lipocalin 2 (LCN-2) is a siderophore-binding protein that mediates transferrin-independent iron transport.	Iron	91-95	lipocalin 2	Rattus norvegicus	0-11
26463963-3	2016	Lipocalin 2 (LCN-2) is a siderophore-binding protein that mediates transferrin-independent iron transport.	Iron	91-95	lipocalin 2	Rattus norvegicus	13-18
26463963-7	2016	Treatment with an iron chelator, deferoxamine (100 mg/kg, intramuscularly), attenuated the TBI-induced upregulation of LCN-2.	Iron	18-22	lipocalin 2	Rattus norvegicus	119-124
27129231-10	2016	TGF-beta1 mRNA levels are increased in mouse models of iron overload, indicating that TGF-beta1 may contribute to hepcidin synthesis under these conditions.	Iron	55-59	transforming growth factor, beta 1	Mus musculus	0-9
26463963-8	2016	In summary, TBI resulted in upregulation of LCN-2 and deferoxamine reduced TBI-induced LCN-2 increase, suggesting LCN-2 may have a role in iron-trafficking after TBI.	Iron	139-143	lipocalin 2	Rattus norvegicus	44-49
26463963-8	2016	In summary, TBI resulted in upregulation of LCN-2 and deferoxamine reduced TBI-induced LCN-2 increase, suggesting LCN-2 may have a role in iron-trafficking after TBI.	Iron	139-143	lipocalin 2	Rattus norvegicus	87-92
26463963-8	2016	In summary, TBI resulted in upregulation of LCN-2 and deferoxamine reduced TBI-induced LCN-2 increase, suggesting LCN-2 may have a role in iron-trafficking after TBI.	Iron	139-143	lipocalin 2	Rattus norvegicus	87-92
26463975-12	2016	Iron-handling protein levels in the brain, including ceruloplasmin and transferrin, were reduced in the minocycline co-injected animals.	Iron	0-4	ceruloplasmin	Rattus norvegicus	53-66
26054392-1	2015	BACKGROUND: HFE, a major regulator of iron (Fe) homeostasis, has been suggested to be under positive selection in both European and Asian populations.	Iron	44-46	homeostatic iron regulator	Homo sapiens	12-15
26054392-3	2015	Identifying the adaptive HFE variants in Asians will not only elucidate the evolutionary history and the genetic basis of population difference in Fe status, but also assist the future practice of genome-informed dietary recommendation.	Iron	147-149	homeostatic iron regulator	Homo sapiens	25-28
26054392-11	2015	Moreover, natural selection on HFE may have contributed to elevated Fe absorption in Asians.	Iron	68-70	homeostatic iron regulator	Homo sapiens	31-34
27129231-10	2016	TGF-beta1 mRNA levels are increased in mouse models of iron overload, indicating that TGF-beta1 may contribute to hepcidin synthesis under these conditions.	Iron	55-59	transforming growth factor, beta 1	Mus musculus	86-95
26053632-2	2015	Our study demonstrates that MMS19/MET18 in Arabidopsis thaliana interacts with the cytoplasmic Fe-S cluster assembly complex but is not an essential component of the complex.	Iron	95-99	ARM repeat superfamily protein	Arabidopsis thaliana	34-39
29421281-1	2016	Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes.	Iron	0-4	transferrin receptor	Homo sapiens	144-148
29421281-1	2016	Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes.	Iron	0-4	transferrin receptor	Homo sapiens	152-156
27129231-11	2016	In conclusion, these data demonstrate that a complex regulatory network involving TGF-beta1 and BMP6 may control the sensing of systemic and/or hepatic iron levels.	Iron	152-156	transforming growth factor, beta 1	Mus musculus	82-91
29421281-1	2016	Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes.	Iron	202-206	transferrin receptor	Homo sapiens	152-156
27007712-0	2016	Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation.	Iron	23-27	lipocalin 2	Mus musculus	0-11
26418826-3	2016	Associations exist between reduced iron intake and progression of COPD and in reduction of iron status with declining lung function.	Iron	35-39	COPD	Homo sapiens	66-70
26418826-7	2016	Future research can be directed to establish best practice standards for the use of iron supplementation in COPD.	Iron	84-88	COPD	Homo sapiens	108-112
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	6-8	Isd11p	Saccharomyces cerevisiae S288C	202-207
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	322-324	Isd11p	Saccharomyces cerevisiae S288C	202-207
27007712-0	2016	Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation.	Iron	105-109	lipocalin 2	Mus musculus	0-11
26059599-7	2015	Countering these factors, the iron-loaded livers demonstrated a significant decrease in CHOP, which has recently been implicated in the development of hepatocellular carcinoma, as well as a reciprocal increase in C/EBPalpha and decrease in Yes-associated protein.	Iron	30-34	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	213-223
27034532-5	2016	Human hemochromatosis protein (HFE) is a membrane bound mediator of iron transport expressed at high levels within placenta.	Iron	68-72	homeostatic iron regulator	Homo sapiens	31-34
27007712-3	2016	In this study, we investigated the role of iron-binding/trafficking innate immune protein, lipocalin 2 (Lcn2, aka siderocalin) on iron and CI homeostasis using Lcn2 knockout (KO) mice and their WT littermates.	Iron	130-134	lipocalin 2	Mus musculus	104-108
26484920-2	2016	We have shown in this study that chelatable iron accumulates in the aged rat brain along with overexpression of transferrin receptor 1 (TfR1) and ferritin, accompanied by significant alterations in amyloid-beta (Abeta) peptide homeostasis in the aging brain, such as an increased production of the amyloid-beta protein precursor, a decreased level of neprilysin, and increased accumulation of Abeta42.	Iron	44-48	transferrin receptor	Rattus norvegicus	112-134
25649872-4	2015	Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation.	Iron	163-167	solute carrier family 39 member 8	Rattus norvegicus	0-4
26484920-2	2016	We have shown in this study that chelatable iron accumulates in the aged rat brain along with overexpression of transferrin receptor 1 (TfR1) and ferritin, accompanied by significant alterations in amyloid-beta (Abeta) peptide homeostasis in the aging brain, such as an increased production of the amyloid-beta protein precursor, a decreased level of neprilysin, and increased accumulation of Abeta42.	Iron	44-48	transferrin receptor	Rattus norvegicus	136-140
25649872-4	2015	Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation.	Iron	163-167	transferrin receptor	Rattus norvegicus	44-64
26484920-3	2016	When aged rats are given daily the iron chelator, deferasirox, over a period of more than 4 months starting from the 18th month, the age-related accumulation of iron and overexpression of TfR1 and ferritin in the brain are significantly prevented.	Iron	35-39	transferrin receptor	Rattus norvegicus	188-192
27007712-4	2016	Administration of iron either systemically or via dietary intake strikingly upregulated Lcn2 in the serum, urine, feces, and liver of WT mice.	Iron	18-22	lipocalin 2	Mus musculus	88-92
26484920-6	2016	The analysis of the results together suggests that iron accumulation and oxidative stress interact at multiple levels that include transcriptional and post-transcriptional mechanisms to bring about changes in the expression levels of TfR1 and ferritin and also alterations in Abeta peptide metabolism in the aging rat brain.	Iron	51-55	transferrin receptor	Rattus norvegicus	234-238
25649872-4	2015	Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation.	Iron	163-167	transferrin receptor	Rattus norvegicus	121-141
27007712-10	2016	Collectively, our results suggest that Lcn2 may facilitate hypoferremia, suppress CI generation and prevent iron-mediated adverse effects.	Iron	108-112	lipocalin 2	Mus musculus	39-43
27019046-4	2016	Reduced FXN protein results in mitochondrial dysfunction and iron accumulation leading to increased oxidative stress and cell death in the nervous system and heart.	Iron	61-65	frataxin	Homo sapiens	8-11
26611242-2	2016	Recently, a novel pathway was described whereby iron stimulates the ubiquitination and proteasomal degradation of the trace mineral transporter ZIP14.	Iron	48-52	solute carrier family 39 member 14	Homo sapiens	144-149
27656215-10	2016	Double staining for iron and CD68 revealed that most of the iron-positive cells were CD68-positive macrophages.	Iron	60-64	Cd68 molecule	Rattus norvegicus	29-33
27656215-10	2016	Double staining for iron and CD68 revealed that most of the iron-positive cells were CD68-positive macrophages.	Iron	60-64	Cd68 molecule	Rattus norvegicus	85-89
27504292-14	2016	Sol TFR emerged as a better parameter to detect iron deficiency in patients of non- haemolytic anaemia in contrast to iron profile and ferritin levels.	Iron	48-52	transferrin receptor	Homo sapiens	4-7
26497867-4	2015	Further evaluation revealed that the patient was homozygous for the HFE H63D gene mutation, associated with hereditary hemochromatosis.Both Busulfan and iron overload related to HFE H63D homozygosity can cause oxidative stress resulting in cellular injury, and the cumulative effects of these risk factors are possibly responsible for the severe hepatocellular injury in this case, making our patient the first-known case of subacute hepatic necrosis related to busulfan administration.	Iron	153-157	homeostatic iron regulator	Homo sapiens	68-71
26497867-4	2015	Further evaluation revealed that the patient was homozygous for the HFE H63D gene mutation, associated with hereditary hemochromatosis.Both Busulfan and iron overload related to HFE H63D homozygosity can cause oxidative stress resulting in cellular injury, and the cumulative effects of these risk factors are possibly responsible for the severe hepatocellular injury in this case, making our patient the first-known case of subacute hepatic necrosis related to busulfan administration.	Iron	153-157	homeostatic iron regulator	Homo sapiens	178-181
27106929-9	2016	In conclusion and as predicted from its proposed role in iron sulfur cluster (ISC) biosynthesis, disruption of frataxin primarily causes impaired function of ISC-containing enzymes, whereas other consequences, including elevated ROS production and iron accumulation, appear secondary.	Iron	57-61	frataxin	Homo sapiens	111-119
26941001-6	2016	In each center, conserved amino acids known to be involved in sulfur and iron donation by Nfs1 and Yfh1, respectively, are in close proximity to the Fe-S cluster-coordinating residues of Isu1.	Iron	73-77	NFS1 cysteine desulfurase	Homo sapiens	90-94
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	75-79	Lso2p	Saccharomyces cerevisiae S288C	9-13
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	75-79	Lso2p	Saccharomyces cerevisiae S288C	113-117
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	143-147	Lso2p	Saccharomyces cerevisiae S288C	9-13
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	143-147	Lso2p	Saccharomyces cerevisiae S288C	113-117
26941001-6	2016	In each center, conserved amino acids known to be involved in sulfur and iron donation by Nfs1 and Yfh1, respectively, are in close proximity to the Fe-S cluster-coordinating residues of Isu1.	Iron	149-153	NFS1 cysteine desulfurase	Homo sapiens	90-94
26993237-7	2016	These novel findings highlight the involvement of calcium-dependent CBL-CIPK23 complexes in the regulation of iron acquisition.	Iron	110-114	cystathionine beta-lyase	Arabidopsis thaliana	68-71
26602920-7	2015	The relative expression of genes involved in Fe-transport (SlIRT1 and SlIRT2) and Fe(III) chelates reductase oxidase (SlFRO1) were relatively reduced in "Roggusanmaru", while increased in "Super Doterang" cultivar under Fe deficient conditions.	Iron	45-47	ferric-chelate reductase	Solanum lycopersicum	118-124
26332507-2	2015	Lcn2 binds iron-laden bacterial siderophores, chemo-attracts neutrophils and has immunomodulatory and apoptosis-regulating effects.	Iron	11-15	lipocalin 2	Mus musculus	0-4
26332507-3	2015	In this study, we show that upon infection with Salmonella enterica serovar Typhimurium, Lcn2 promotes iron export from Salmonella-infected macrophages, which reduces cellular iron content and enhances the generation of pro-inflammatory cytokines.	Iron	103-107	lipocalin 2	Mus musculus	89-93
26332507-3	2015	In this study, we show that upon infection with Salmonella enterica serovar Typhimurium, Lcn2 promotes iron export from Salmonella-infected macrophages, which reduces cellular iron content and enhances the generation of pro-inflammatory cytokines.	Iron	176-180	lipocalin 2	Mus musculus	89-93
26332507-5	2015	Lcn2(-/-) macrophages have elevated IL-10 levels as a consequence of increased iron content.	Iron	79-83	lipocalin 2	Mus musculus	0-4
26475181-7	2015	Dietary Pi regulated the messenger RNA expression of iron-regulated genes, including divalent metal transporter 1, duodenal cytochrome B, and hepcidin.	Iron	53-57	cytochrome b reductase 1	Rattus norvegicus	115-136
27080392-1	2016	BACKGROUND: Activation of NMDA receptors can induce iron movement into neurons by the small GTPase Dexras1 via the divalent metal transporter 1 (DMT1).	Iron	52-56	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	115-143
26209973-8	2015	Moreover, Fe transport-related genes (NtPIC1, NtNRAMP1, and NtFER1) were upregulated in NtPIC1-OE plants, while Fe deficiency-related genes (NtFRO1, NtIRT1, and NtZIP1) that mediate Cd uptake were downregulated.	Iron	10-12	protein TIC 21, chloroplastic-like	Nicotiana tabacum	88-94
26209973-8	2015	Moreover, Fe transport-related genes (NtPIC1, NtNRAMP1, and NtFER1) were upregulated in NtPIC1-OE plants, while Fe deficiency-related genes (NtFRO1, NtIRT1, and NtZIP1) that mediate Cd uptake were downregulated.	Iron	112-114	protein TIC 21, chloroplastic-like	Nicotiana tabacum	88-94
26209973-10	2015	Overall, our results demonstrate that overexpression of NtPIC1 is an efficient way to increase shoot Fe concentrations and reduce Cd uptake/accumulation in plants.	Iron	101-103	protein TIC 21, chloroplastic-like	Nicotiana tabacum	56-62
27080392-1	2016	BACKGROUND: Activation of NMDA receptors can induce iron movement into neurons by the small GTPase Dexras1 via the divalent metal transporter 1 (DMT1).	Iron	52-56	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	145-149
27048792-1	2016	The regulation of divalent metal ion transporter DMT1, the primary non-heme iron importer in mammals, is critical for maintaining iron homeostasis.	Iron	76-80	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	49-53
26506412-0	2015	Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1.	Iron	70-74	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	112-140
26342079-2	2015	In mammalian mitochondria, the initial step of the Fe-S cluster assembly process is assisted by the NFS1-ISD11 complex, which delivers sulfur to scaffold protein ISCU during Fe-S cluster synthesis.	Iron	51-55	NFS1 cysteine desulfurase	Homo sapiens	100-104
26342079-2	2015	In mammalian mitochondria, the initial step of the Fe-S cluster assembly process is assisted by the NFS1-ISD11 complex, which delivers sulfur to scaffold protein ISCU during Fe-S cluster synthesis.	Iron	174-178	NFS1 cysteine desulfurase	Homo sapiens	100-104
27048792-1	2016	The regulation of divalent metal ion transporter DMT1, the primary non-heme iron importer in mammals, is critical for maintaining iron homeostasis.	Iron	130-134	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	49-53
27047521-0	2016	The Response of the Root Apex in Plant Adaptation to Iron Heterogeneity in Soil.	Iron	53-57	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	25-29
26456827-2	2015	We hypothesized that the transferrin receptor (Tfr1) might play a role in cardiac iron uptake and used gene targeting to examine the role of Tfr1 in vivo.	Iron	82-86	transferrin receptor	Mus musculus	25-45
26456827-2	2015	We hypothesized that the transferrin receptor (Tfr1) might play a role in cardiac iron uptake and used gene targeting to examine the role of Tfr1 in vivo.	Iron	82-86	transferrin receptor	Mus musculus	47-51
27047521-6	2016	We especially focus on the role of the root apex in dealing with the stresses resulting from Fe shortage and excess.	Iron	93-95	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	44-48
26456827-3	2015	Surprisingly, we found that decreased iron, due to inactivation of Tfr1, was associated with severe cardiac consequences.	Iron	38-42	transferrin receptor	Mus musculus	67-71
26841310-0	2016	Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase.	Iron	58-62	TSRM	Homo sapiens	97-101
26436293-0	2015	Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.	Iron	76-80	nuclear receptor coactivator 4	Danio rerio	19-24
26436293-0	2015	Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.	Iron	76-80	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Danio rerio	91-96
26436293-1	2015	NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability.	Iron	128-132	nuclear receptor coactivator 4	Danio rerio	0-5
26436293-2	2015	However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are poorly understood.	Iron	73-77	nuclear receptor coactivator 4	Danio rerio	64-69
26436293-5	2015	Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.	Iron	57-61	nuclear receptor coactivator 4	Danio rerio	20-25
26436293-5	2015	Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.	Iron	78-82	nuclear receptor coactivator 4	Danio rerio	20-25
26595644-4	2016	Perioperative administration of recombinant Lcn2:siderophore:Fe complex (rLcn2) to recipients resulted in functional and morphological amelioration of the allograft at day 7 almost as efficiently as daily immunosuppression with cyclosporine A (CsA).	Iron	61-63	lipocalin 2	Mus musculus	44-48
26436293-5	2015	Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.	Iron	78-82	nuclear receptor coactivator 4	Danio rerio	113-118
27455625-0	2016	Enhancement of Thermal Damage to Adenocarcinoma Cells by Iron Nanoparticles Modified with MUC1 Aptamer.	Iron	57-61	mucin 1, cell surface associated	Homo sapiens	90-94
26307542-4	2015	In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant"s iron-acquisition response that is typically activated upon iron starvation.	Iron	61-65	ferric reduction oxidase 2	Arabidopsis thaliana	87-113
26288007-1	2015	The 2D-Ising ferromagnetic phase BaFe(2+)2(PO4)2 shows exsolution of up to one-third of its iron content (giving BaFe(3+)1.33(PO4)2) under mild oxidation conditions, leading to nanosized Fe2O3 exsolved clusters.	Iron	92-96	ERC2 intronic transcript 1	Homo sapiens	43-48
26288007-5	2015	For M-rich phases the iron diffusion is hampered so that a significant fraction of superparamagnetic alpha-Fe2O3 particles (100% for BaFe(0.5-x)Co(1.5)(PO4)2) was detected even at 78 K. Although Ni(2+) and Co(2+) ions tend to block Fe diffusion, the crystal structure of BaFe(0.67)Co1(PO4)2 demonstrates a fully ordered rearrangement of Fe(3+) and Co(2+) ions after Fe exsolution.	Iron	22-26	ERC2 intronic transcript 1	Homo sapiens	152-157
26288007-5	2015	For M-rich phases the iron diffusion is hampered so that a significant fraction of superparamagnetic alpha-Fe2O3 particles (100% for BaFe(0.5-x)Co(1.5)(PO4)2) was detected even at 78 K. Although Ni(2+) and Co(2+) ions tend to block Fe diffusion, the crystal structure of BaFe(0.67)Co1(PO4)2 demonstrates a fully ordered rearrangement of Fe(3+) and Co(2+) ions after Fe exsolution.	Iron	22-26	ERC2 intronic transcript 1	Homo sapiens	285-290
27455625-5	2016	In this study, a MUC1 aptamer is conjugated with iron nanoparticles to construct adenocarcinoma-targeting metal contrasts.	Iron	49-53	mucin 1, cell surface associated	Homo sapiens	17-21
26228908-1	2015	Iron nanotube silica composite have been synthesized and studied through particle-size analysis, FTIR, SEM-EDX, TEM, XRD, UV, VSM, TGA-DTA and XPS techniques.	Iron	0-4	T-box transcription factor 1	Homo sapiens	131-134
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Iron	107-109	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	31-36
25753988-0	2015	Increased duodenal iron absorption through up-regulation of divalent metal transporter 1 from enhancement of iron regulatory protein 1 activity in patients with nonalcoholic steatohepatitis.	Iron	19-23	aconitase 1	Homo sapiens	109-134
25753988-12	2015	CONCLUSION: In spite of elevation of serum hepcidin, iron absorption from the GI tract increased through up-regulation of DMT1 by IRP1 activation by humoral factor(s) in sera of patients with NASH.	Iron	53-57	aconitase 1	Homo sapiens	130-134
27036742-3	2015	One bacterial group in particular, Geobacter spp., can couple their respiratory metabolism to the reduction of insoluble minerals, such as iron and manganese oxides, and soluble toxic metals such as uranium.	Iron	139-143	histocompatibility minor 13	Homo sapiens	45-48
26136265-2	2015	Expression of two iron SODs, FSD2 and FSD3, was significantly increased in Arabidopsis in response to NaCl treatment but blocked in transgenic MKK5-RNAi plant, mkk5.	Iron	18-22	Fe superoxide dismutase 2	Arabidopsis thaliana	29-33
26136265-2	2015	Expression of two iron SODs, FSD2 and FSD3, was significantly increased in Arabidopsis in response to NaCl treatment but blocked in transgenic MKK5-RNAi plant, mkk5.	Iron	18-22	Fe superoxide dismutase 3	Arabidopsis thaliana	38-42
28347073-6	2015	This catalytic effect is particularly strong for oxides of redox active metals, such as transition group VII and VIII metals (Mn, Fe, Co, Ni), Cu, and Ce.	Iron	130-132	cytochrome c oxidase subunit 8A	Homo sapiens	113-117
27162978-4	2015	The electrochemically tuned cobalt-nickel-iron oxides grown directly on the three-dimensional carbon fiber electrodes exhibit a low overpotential of 232 mV at current density of 10 mA cm(-2), small Tafel slope of 37.6 mV dec(-1), and exceptional long-term stability of electrolysis for over 100 h in 1 M KOH alkaline medium, superior to most non-noble oxygen evolution catalysts reported so far.	Iron	42-46	deleted in esophageal cancer 1	Homo sapiens	221-227
26401240-11	2015	CONCLUSION: Pulsed wave TDI is an important diagnostic tool for latent cardiac dysfunction in iron-loaded TM patients and is related to iron overload and BNP.	Iron	94-98	natriuretic peptide B	Homo sapiens	154-157
26373309-6	2015	The PtIRT3 gene was clustered with the AtIRT3 gene that was related to zinc and iron transport in plants.	Iron	80-84	iron regulated transporter 3	Arabidopsis thaliana	39-45
26167763-3	2015	The composites filled with 50 wt% of the Fe-Co/NPC-2.0 samples in paraffin show a maximum reflection loss (RL) of -21.7 dB at a thickness of 1.2 mm; in addition, a broad absorption bandwidth for RL &lt; -10 dB which covers from 12.2 to 18 GHz can be obtained, and its minimum reflection loss and bandwidth (RL values exceeding -10 dB) are far greater than those of commercial carbonyl iron powder under a very low thickness (1-1.5 mm).	Iron	385-389	NPC intracellular cholesterol transporter 2	Homo sapiens	47-52
26190773-2	2015	Iron metabolism in mammalian cells is orchestrated posttranscriptionally by iron-regulatory proteins (IRP)-1 and -2.	Iron	0-4	aconitase 1	Homo sapiens	102-115
26262621-1	2015	The adsorption of the proteins CD13, mucin and bovine serum albumin on VLGXE-Au and YNGRT-Au interfaces was monitored by electrochemical impedance spectroscopy in the presence of [Fe(CN)6](3-/4-).	Iron	180-182	alanyl aminopeptidase, membrane	Homo sapiens	31-35
25912790-0	2015	The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity.	Iron	71-75	dynein axonemal heavy chain 8	Homo sapiens	31-41
25841783-2	2015	Loss of frataxin expression affects the production of iron-sulfur clusters and, therefore, mitochondrial energy production.	Iron	54-58	frataxin	Drosophila melanogaster	8-16
25841783-6	2015	We showed that frataxin-deficient flies were hypersensitive toward dietary iron and developed an iron-dependent decay of mitochondrial functions.	Iron	75-79	frataxin	Drosophila melanogaster	15-23
25841783-6	2015	We showed that frataxin-deficient flies were hypersensitive toward dietary iron and developed an iron-dependent decay of mitochondrial functions.	Iron	97-101	frataxin	Drosophila melanogaster	15-23
25841783-7	2015	In the fly model exhibiting only partial frataxin loss, we demonstrated that the inability to activate ferritin translation and the enhancement of mitochondrial iron uptake via mitoferrin upregulation were likely the key molecular events behind the iron-induced phenotype.	Iron	249-253	frataxin	Drosophila melanogaster	41-49
26138268-3	2015	Frataxin is a mitochondrial protein that functions primarily in iron-sulfur cluster synthesis.	Iron	64-68	frataxin	Homo sapiens	0-8
25186232-3	2015	Compelling data indicated that PICALM affects AD risk primarily by modulating production, transportation, and clearance of beta-amyloid (Abeta) peptide, but other Abeta-independent pathways are discussed, including tauopathy, synaptic dysfunction, disorganized lipid metabolism, immune disorder, and disrupted iron homeostasis.	Iron	310-314	phosphatidylinositol binding clathrin assembly protein	Homo sapiens	31-37
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	4-8	lipocalin 2	Rattus norvegicus	37-48
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	4-8	lipocalin 2	Rattus norvegicus	50-54
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	4-8	lipocalin 2	Rattus norvegicus	76-80
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	117-121	lipocalin 2	Rattus norvegicus	37-48
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	117-121	lipocalin 2	Rattus norvegicus	50-54
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	117-121	lipocalin 2	Rattus norvegicus	76-80
26004810-9	2015	Apo-LCN2 without iron caused no significant differences in neuronal Bim expression or cell survival, whereas holo-LCN2 consisting of LCN2:iron:enterochelin complex increased Bim mRNA expression and decreased neuronal survival.	Iron	138-142	lipocalin 2	Rattus norvegicus	114-118
26144971-6	2015	The induction of mitophagy is part of a hypoxia-like, iron starvation response triggered upon frataxin depletion and causally involved in animal lifespan extension.	Iron	54-58	frataxin	Homo sapiens	94-102
26184159-4	2015	The overexpression of TfR1 was well tolerated by the cells but Fth1 was found to affect the cell"s iron homeostasis, leading to phenotypic changes in the absence of iron supplementation and an upregulation in transcript and protein levels of the cell"s endogenous transferrin receptor.	Iron	165-169	transferrin receptor	Gallus gallus	22-26
26276291-8	2015	CONCLUSIONS: Tf and TfR were important transporters in brain tissue excessive load iron transport after ICH, and detecting the expression levels of the two indicators can provide a reference for prognosis treatment in ICH.	Iron	83-87	transferrin receptor	Rattus norvegicus	20-23
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Iron	65-69	ceruloplasmin	Rattus norvegicus	0-13
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Iron	65-69	ceruloplasmin	Rattus norvegicus	15-17
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Iron	168-172	ceruloplasmin	Rattus norvegicus	0-13
25656940-2	2015	Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic ferric form, which cooperated with ferroportin1 (FP1) facilitating the export of iron from cells.	Iron	168-172	ceruloplasmin	Rattus norvegicus	15-17
25656940-3	2015	To elucidate if the abnormal expression of CP is involved in the nigral iron accumulation, here, we investigated CP expression in the SN of rats lesioned by 6-hydroxydopamine (6-OHDA).	Iron	72-76	ceruloplasmin	Rattus norvegicus	43-45
25656940-9	2015	These results show that FP1 and CP colocalize in the rat brain, indicating the coordinated actions of the two proteins in the cellular iron export, and suggest that decreased expression of CP in the SN is involved in the nigral iron accumulation of 6-OHDA-lesioned rats.	Iron	228-232	ceruloplasmin	Rattus norvegicus	32-34
25656940-9	2015	These results show that FP1 and CP colocalize in the rat brain, indicating the coordinated actions of the two proteins in the cellular iron export, and suggest that decreased expression of CP in the SN is involved in the nigral iron accumulation of 6-OHDA-lesioned rats.	Iron	228-232	ceruloplasmin	Rattus norvegicus	189-191
26236931-5	2015	RESULTS: One patient had hereditary (-HFE) hemochromatosis complicated with Gilbert"s syndrome, for which the pattern of iron deposition was similar to that of the four patients with Gilbert"s syndrome.	Iron	121-125	homeostatic iron regulator	Homo sapiens	38-41
25863172-2	2015	There are indications that C282Y and H63D polymorphisms of HFE genes involved in iron metabolism might contribute to the pathogenesis of PD in some cases.	Iron	81-85	homeostatic iron regulator	Homo sapiens	59-62
25802332-4	2015	Modulation of TGF-beta signaling, involving ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-delta, is responsible for iron-induced C3 expression.	Iron	120-124	SMAD family member 3	Homo sapiens	52-57
25802332-6	2015	Pharmacologic inhibition of either ERK1/2 or SMAD3 phosphorylation decreased iron-induced C3 expression levels.	Iron	77-81	SMAD family member 3	Homo sapiens	45-50
25802332-7	2015	Knockdown of SMAD3 blocked the iron-induced up-regulation and nuclear accumulation of CCAAT/enhancer-binding protein-delta, a transcription factor that has been shown previously to bind the basic leucine zipper 1 domain in the C3 promoter.	Iron	31-35	SMAD family member 3	Homo sapiens	13-18
25652229-0	2015	Iron-dependent turnover of IRP-1/c-aconitase in kidney cells.	Iron	0-4	aconitase 1	Rattus norvegicus	27-32
25652229-2	2015	The bifunctional iron-regulatory protein IRP-1 potentially regulates iron trafficking and participates in citrate metabolism as a cytosolic (c-) aconitase.	Iron	17-21	aconitase 1	Rattus norvegicus	41-46
25652229-3	2015	We investigated the role of cellular iron status in determining the expression and dynamics of IRP-1 in two renal cell types, with the aim of identifying a role of the protein in cellular ROS levels, citrate metabolism and glutamate production.	Iron	37-41	aconitase 1	Rattus norvegicus	95-100
25652229-4	2015	The effects of iron supplementation and chelation on IRP-1 protein and mRNA levels and protein turnover were compared in cultured primary rat mesangial cells and a porcine renal tubule cell line (LLC-PK1).	Iron	15-19	aconitase 1	Rattus norvegicus	53-58
25652229-6	2015	Iron supplementation decreased IRP-1 levels (e.g., approx.	Iron	0-4	aconitase 1	Rattus norvegicus	31-36
25591911-8	2015	These results suggest that iron may positively regulate STAT1 phosphorylation and following signaling to express ISG56, RIG-I and CXCL10 in U373MG cells treated with poly IC.	Iron	27-31	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	113-118
25591911-9	2015	Iron may contribute to innate immune and inflammatory reactions elicited by the TLR3 signaling in astrocytes, and may play an important role in neuroinflammatory diseases.	Iron	0-4	toll like receptor 3	Homo sapiens	80-84
25899529-8	2015	CONCLUSION: These findings demonstrate that the activity of beta2-M is mediated by the beta2-M/HFE complex, which regulates intracellular iron homeostasis and HIF-1alpha and ultimately induces EMT in HK2 cells.	Iron	138-142	homeostatic iron regulator	Homo sapiens	95-98
24909164-5	2015	As a consequence, IRP1 target genes, such as the transferrin receptor (TfR1), a membrane-associated glycoprotein critical for iron uptake and cell proliferation, are controlled by SIRT3.	Iron	126-130	aconitase 1	Homo sapiens	18-22
24909164-5	2015	As a consequence, IRP1 target genes, such as the transferrin receptor (TfR1), a membrane-associated glycoprotein critical for iron uptake and cell proliferation, are controlled by SIRT3.	Iron	126-130	transferrin receptor	Homo sapiens	71-75
24909164-7	2015	SIRT3 null cells contain high levels of iron and lose iron-dependent TfR1 regulation.	Iron	54-58	transferrin receptor	Homo sapiens	69-73
24909164-12	2015	Our data uncover a novel role of SIRT3 in cellular iron metabolism through IRP1 regulation and suggest that SIRT3 functions as a tumor suppressor, in part, by modulating cellular iron metabolism.	Iron	51-55	aconitase 1	Homo sapiens	75-79
25557851-2	2015	The serine protease TMPRSS6 attenuates hepcidin production in response to iron stores.	Iron	74-78	transmembrane serine protease 6	Mus musculus	20-27
25315005-4	2015	Dietary iron affects circadian glucose metabolism through heme-mediated regulation of the interaction of nuclear receptor subfamily 1 group d member 1 (Rev-Erbalpha) with its cosuppressor nuclear receptor corepressor 1 (NCOR).	Iron	8-12	nuclear receptor co-repressor 1	Mus musculus	188-218
25315005-4	2015	Dietary iron affects circadian glucose metabolism through heme-mediated regulation of the interaction of nuclear receptor subfamily 1 group d member 1 (Rev-Erbalpha) with its cosuppressor nuclear receptor corepressor 1 (NCOR).	Iron	8-12	nuclear receptor co-repressor 1	Mus musculus	220-224
25315005-8	2015	Dietary iron modulates levels of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), a transcriptional activator of ALAS1, to affect hepatic heme.	Iron	8-12	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	33-100
25315005-8	2015	Dietary iron modulates levels of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), a transcriptional activator of ALAS1, to affect hepatic heme.	Iron	8-12	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	102-112
25315005-9	2015	Treatment of mice with the antioxidant N-acetylcysteine diminishes PGC-1alpha variation observed among the iron diets, suggesting that iron is acting through reactive oxygen species signaling.	Iron	107-111	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	67-77
25315005-9	2015	Treatment of mice with the antioxidant N-acetylcysteine diminishes PGC-1alpha variation observed among the iron diets, suggesting that iron is acting through reactive oxygen species signaling.	Iron	135-139	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	67-77
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	40-44	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	153-181
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	40-44	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	183-187
25699589-6	2015	However, a grxs17 knockout Arabidopsis mutant exhibited only a minor decrease in the activities of iron-sulfur enzymes, suggesting that its primary function is as a disulfide oxidoreductase.	Iron	99-103	thioredoxin family protein	Arabidopsis thaliana	11-17
25762074-6	2015	MAD-28 was found to target the mitochondria of cancer cells and displayed a surprising similarity in its effects to the effects of mNT/NAF-1 shRNA suppression in cancer cells, causing a decrease in respiration and mitochondrial membrane potential, as well as an increase in mitochondrial iron content and glycolysis.	Iron	288-292	max binding protein	Mus musculus	131-134
25890235-4	2015	Using neutrophils isolated from the knock-in mice, we identified several PKCdelta substrates, one of which was lipocalin-2 (LCN2), which is an iron-binding protein that can trigger apoptosis by reducing intracellular iron concentrations.	Iron	143-147	lipocalin 2	Mus musculus	111-122
25762186-8	2015	The histopathological studies revealed that the site of cell injection was infiltrated by inflammatory cells progressively and the iron-positive cells were macrophages identified by CD68 staining, but very few or no DAPI-positive stem cells at 4 weeks after cells transplantation.	Iron	131-135	Cd68 molecule	Rattus norvegicus	182-186
25669896-1	2015	We report non-volatile electric-field control of magnetism modulation in Fe/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 (PMN-PT) heterostructure by fabricating an epitaxial Fe layer on a PMN-PT substrate using a molecular beam epitaxy technique.	Iron	73-75	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	79-82
25293352-9	2015	Contrasting modification by the HFE polymorphisms H63D and C282Y may suggest that the modification is not simply the result of increased iron.	Iron	137-141	homeostatic iron regulator	Homo sapiens	32-35
25548455-12	2015	The mean HbA2 levels in both iron deplete and iron replete groups were clearly &gt;4 %, suggesting that HPLC identified nearly all high HbA2 beta-thalassemia trait even in spite of iron deficiency.	Iron	29-33	hemoglobin subunit alpha 2	Homo sapiens	9-13
25548455-12	2015	The mean HbA2 levels in both iron deplete and iron replete groups were clearly &gt;4 %, suggesting that HPLC identified nearly all high HbA2 beta-thalassemia trait even in spite of iron deficiency.	Iron	29-33	hemoglobin subunit alpha 2	Homo sapiens	136-140
25548455-12	2015	The mean HbA2 levels in both iron deplete and iron replete groups were clearly &gt;4 %, suggesting that HPLC identified nearly all high HbA2 beta-thalassemia trait even in spite of iron deficiency.	Iron	46-50	hemoglobin subunit alpha 2	Homo sapiens	9-13
25548455-12	2015	The mean HbA2 levels in both iron deplete and iron replete groups were clearly &gt;4 %, suggesting that HPLC identified nearly all high HbA2 beta-thalassemia trait even in spite of iron deficiency.	Iron	46-50	hemoglobin subunit alpha 2	Homo sapiens	136-140
25661858-9	2015	CONCLUSIONS: Almost half of patients with stable CAD have profound bone marrow iron depletion that can be accurately assessed non-invasively using serum soluble transferrin receptor.	Iron	79-83	transferrin receptor	Homo sapiens	161-181
25318588-13	2015	Hepcidin or enterocyte iron levels may be involved in the regulation of age-dependent FPN1, DMT1, and DcytB expression in the duodenum.	Iron	23-27	cytochrome b reductase 1	Rattus norvegicus	102-107
25693854-11	2015	In addition, a decrease in vimentin along an increase in E-cadherin in renal gene expression was observed in CKD rats with iron chelation.	Iron	123-127	vimentin	Rattus norvegicus	27-35
25693854-13	2015	Similarly, increased renal gene expression of CD68, tumor necrosis factor-alpha and monocyte chemoattractant protein-1 was suppressed in CKD rats with iron chelation.	Iron	151-155	Cd68 molecule	Rattus norvegicus	46-50
26016389-2	2015	In human mitochondria, the core Fe-S biosynthetic enzymatic complex (called SDUF) consists of NFS1, ISD11, ISCU2, and frataxin (FXN) protein components.	Iron	32-36	NFS1 cysteine desulfurase	Homo sapiens	94-98
26016389-2	2015	In human mitochondria, the core Fe-S biosynthetic enzymatic complex (called SDUF) consists of NFS1, ISD11, ISCU2, and frataxin (FXN) protein components.	Iron	32-36	frataxin	Homo sapiens	118-126
26016389-2	2015	In human mitochondria, the core Fe-S biosynthetic enzymatic complex (called SDUF) consists of NFS1, ISD11, ISCU2, and frataxin (FXN) protein components.	Iron	32-36	frataxin	Homo sapiens	128-131
26016518-0	2015	Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe-S Assembly Complex.	Iron	61-65	frataxin	Homo sapiens	0-8
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	30-34	NFS1 cysteine desulfurase	Homo sapiens	81-85
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	30-34	frataxin	Homo sapiens	105-113
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	30-34	frataxin	Homo sapiens	115-118
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	142-146	NFS1 cysteine desulfurase	Homo sapiens	81-85
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	142-146	frataxin	Homo sapiens	105-113
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	142-146	frataxin	Homo sapiens	115-118
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	161-165	NFS1 cysteine desulfurase	Homo sapiens	81-85
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	161-165	frataxin	Homo sapiens	105-113
26016518-2	2015	In human mitochondria, a core Fe-S assembly complex [called SDUF and composed of NFS1, ISD11, ISCU2, and frataxin (FXN) proteins] synthesizes Fe-S clusters from iron, cysteine sulfur, and reducing equivalents and then transfers these intact clusters to target proteins.	Iron	161-165	frataxin	Homo sapiens	115-118
26016518-4	2015	Recent studies have concluded that FXN promotes the synthesis of [4Fe-4S] clusters on the mammalian Fe-S assembly complex.	Iron	100-104	frataxin	Homo sapiens	35-38
26016518-11	2015	Our results indicate that FXN accelerates a rate-limiting sulfur transfer step in the synthesis of [2Fe-2S] clusters on the human Fe-S assembly complex.	Iron	130-134	frataxin	Homo sapiens	26-29
25588817-1	2015	3-Hydroxyanthranilate 3,4-dioxygenase () is a non-heme iron dependent enzyme.	Iron	55-59	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	0-37
25499799-0	2015	Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson"s disease and aging.	Iron	59-63	monoamine oxidase A	Rattus norvegicus	89-108
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Iron	131-133	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	31-36
26255344-5	2015	During the development of resistance phenotype the tumor tissue also exhibited increased "free iron" concentration that putatively correlate with elevation of ROS generation and levels of MMP-2 and MMP-9 active forms.	Iron	95-99	matrix metallopeptidase 2	Homo sapiens	188-193
26212225-7	2016	This effect was likely mediated by the up-regulation of transferrin receptor and ferritin, the main cellular proteins involved in iron homeostasis, at last affecting the labile iron pool.	Iron	130-134	transferrin receptor	Homo sapiens	56-76
26167168-7	2015	The up-regulation of LeNRAMP3 gene in leaf of Ikram/Maxifort could explain the better nutritional status of interspecific grafting combination (higher Fe, Mn, and Zn).	Iron	151-153	metal transporter	Solanum lycopersicum	21-29
26212225-7	2016	This effect was likely mediated by the up-regulation of transferrin receptor and ferritin, the main cellular proteins involved in iron homeostasis, at last affecting the labile iron pool.	Iron	177-181	transferrin receptor	Homo sapiens	56-76
25572394-2	2015	Alteration of iron homeostasis is believed to result from impaired function of PrP(C) in neuronal iron uptake via its ferrireductase activity.	Iron	14-18	prion protein	Mus musculus	79-82
25572394-2	2015	Alteration of iron homeostasis is believed to result from impaired function of PrP(C) in neuronal iron uptake via its ferrireductase activity.	Iron	98-102	prion protein	Mus musculus	79-82
27433622-3	2016	The Ce and Fe modified Ni/gamma-A120, catalyst was characterized by BET surface area analysis, X-ray diffraction (XRD), H2 temperature-programmed reduction (TPR), H2 chemisorption, CO2 temperature-programmed desorption (TPD) and SEM.	Iron	11-13	delta/notch like EGF repeat containing	Homo sapiens	68-71
25572394-5	2015	Here, we report that PrP(C) promotes the uptake of transferrin (Tf) and non-Tf-bound iron (NTBI) by the kidney in vivo and mainly NTBI by PT cells in vitro.	Iron	85-89	prion protein	Mus musculus	21-24
25572394-6	2015	Thus, uptake of (59)Fe administered by gastric gavage, intravenously, or intraperitoneally was significantly lower in PrP-knock-out (PrP(-/-)) mouse kidney relative to PrP(+/+) controls.	Iron	20-22	prion protein	Mus musculus	118-121
25572394-6	2015	Thus, uptake of (59)Fe administered by gastric gavage, intravenously, or intraperitoneally was significantly lower in PrP-knock-out (PrP(-/-)) mouse kidney relative to PrP(+/+) controls.	Iron	20-22	prion protein	Mus musculus	133-136
25572394-6	2015	Thus, uptake of (59)Fe administered by gastric gavage, intravenously, or intraperitoneally was significantly lower in PrP-knock-out (PrP(-/-)) mouse kidney relative to PrP(+/+) controls.	Iron	20-22	prion protein	Mus musculus	133-136
25572394-10	2015	Furthermore, excess NTBI and hemin caused aggregation of PrP(C) to a detergent-insoluble form, limiting iron uptake.	Iron	104-108	prion protein	Mus musculus	57-60
25572394-11	2015	Together, these observations suggest that PrP(C) promotes retrieval of iron from the glomerular filtrate via its ferrireductase activity and modulates kidney iron metabolism.	Iron	71-75	prion protein	Mus musculus	42-45
25448035-6	2015	Studies in different model systems demonstrated a role for NAF-1 and mNT in the regulation of cellular iron, calcium and ROS homeostasis, and uncovered a key role for NEET proteins in critical processes, such as cancer cell proliferation and tumor growth, lipid and glucose homeostasis in obesity and diabetes, control of autophagy, longevity in mice, and senescence in plants.	Iron	103-107	nuclear assembly factor 1 ribonucleoprotein	Mus musculus	59-64
25448035-6	2015	Studies in different model systems demonstrated a role for NAF-1 and mNT in the regulation of cellular iron, calcium and ROS homeostasis, and uncovered a key role for NEET proteins in critical processes, such as cancer cell proliferation and tumor growth, lipid and glucose homeostasis in obesity and diabetes, control of autophagy, longevity in mice, and senescence in plants.	Iron	103-107	max binding protein	Mus musculus	69-72
25825391-4	2015	In mouse and human vascular and endothelial tissue affected by PH, miR-210 was elevated accompanied by decreased ISCU1/2 and Fe-S integrity.	Iron	125-129	microRNA 210	Homo sapiens	67-74
25572394-11	2015	Together, these observations suggest that PrP(C) promotes retrieval of iron from the glomerular filtrate via its ferrireductase activity and modulates kidney iron metabolism.	Iron	158-162	prion protein	Mus musculus	42-45
26710823-6	2016	The HFE gene regulates iron uptake and secondarily modulates lead metabolism.	Iron	23-27	homeostatic iron regulator	Homo sapiens	4-7
25968216-0	2015	Research of polishing process to control the iron contamination on the magnetorheological finished KDP crystal surface.	Iron	45-49	WNK lysine deficient protein kinase 1	Homo sapiens	99-102
25968216-2	2015	MRF polishing is easy to result in the embedding of carbonyl iron (CI) powders; meanwhile, Fe contamination on the KDP crystal surface will affect the laser induced damage threshold seriously.	Iron	91-93	WNK lysine deficient protein kinase 1	Homo sapiens	115-118
25968216-5	2015	Furthermore, on the KDP crystal surface, magnetorheological fluids residua inevitably exist after polishing and in which the Fe contamination cannot be removed completely by initial ultrasonic cleaning.	Iron	125-127	WNK lysine deficient protein kinase 1	Homo sapiens	20-23
25715406-8	2015	Systemic iron homeostasis is not compromised in Vk*MYC animals, but high expression of the iron importer CD71 by bone marrow plasma cells and iron accumulation in bone marrow macrophages suggest that iron competition takes place in the local multiple myeloma microenvironment, which might contribute to anemia.	Iron	91-95	transferrin receptor	Mus musculus	105-109
25715406-8	2015	Systemic iron homeostasis is not compromised in Vk*MYC animals, but high expression of the iron importer CD71 by bone marrow plasma cells and iron accumulation in bone marrow macrophages suggest that iron competition takes place in the local multiple myeloma microenvironment, which might contribute to anemia.	Iron	91-95	transferrin receptor	Mus musculus	105-109
25715406-8	2015	Systemic iron homeostasis is not compromised in Vk*MYC animals, but high expression of the iron importer CD71 by bone marrow plasma cells and iron accumulation in bone marrow macrophages suggest that iron competition takes place in the local multiple myeloma microenvironment, which might contribute to anemia.	Iron	91-95	transferrin receptor	Mus musculus	105-109
30713878-1	2015	Mutations in the fatty-acid 2-hydroxylase (FA2H) gene cause an autosomal recessive spastic paraplegia (SPG35), often associating with cerebellar ataxia; cerebral MRI may show iron accumulation in the basal ganglia, leading to the inclusion of SPG35 among the causes of neurodegeneration with brain iron accumulation.	Iron	175-179	fatty acid 2-hydroxylase	Homo sapiens	17-41
26675642-1	2016	We have designed a new mesoporous SBA-15 supported chiral Fe(III)-salen material (Fe@SBSAL) having high BET surface area and porosity.	Iron	58-60	delta/notch like EGF repeat containing	Homo sapiens	104-107
30713878-1	2015	Mutations in the fatty-acid 2-hydroxylase (FA2H) gene cause an autosomal recessive spastic paraplegia (SPG35), often associating with cerebellar ataxia; cerebral MRI may show iron accumulation in the basal ganglia, leading to the inclusion of SPG35 among the causes of neurodegeneration with brain iron accumulation.	Iron	175-179	fatty acid 2-hydroxylase	Homo sapiens	43-47
30713878-1	2015	Mutations in the fatty-acid 2-hydroxylase (FA2H) gene cause an autosomal recessive spastic paraplegia (SPG35), often associating with cerebellar ataxia; cerebral MRI may show iron accumulation in the basal ganglia, leading to the inclusion of SPG35 among the causes of neurodegeneration with brain iron accumulation.	Iron	175-179	fatty acid 2-hydroxylase	Homo sapiens	103-108
30713878-1	2015	Mutations in the fatty-acid 2-hydroxylase (FA2H) gene cause an autosomal recessive spastic paraplegia (SPG35), often associating with cerebellar ataxia; cerebral MRI may show iron accumulation in the basal ganglia, leading to the inclusion of SPG35 among the causes of neurodegeneration with brain iron accumulation.	Iron	298-302	fatty acid 2-hydroxylase	Homo sapiens	17-41
30713878-1	2015	Mutations in the fatty-acid 2-hydroxylase (FA2H) gene cause an autosomal recessive spastic paraplegia (SPG35), often associating with cerebellar ataxia; cerebral MRI may show iron accumulation in the basal ganglia, leading to the inclusion of SPG35 among the causes of neurodegeneration with brain iron accumulation.	Iron	298-302	fatty acid 2-hydroxylase	Homo sapiens	43-47
30713878-1	2015	Mutations in the fatty-acid 2-hydroxylase (FA2H) gene cause an autosomal recessive spastic paraplegia (SPG35), often associating with cerebellar ataxia; cerebral MRI may show iron accumulation in the basal ganglia, leading to the inclusion of SPG35 among the causes of neurodegeneration with brain iron accumulation.	Iron	298-302	fatty acid 2-hydroxylase	Homo sapiens	103-108
30713878-3	2015	We found 5 novel patients (from two families) with mutations in the FA2H gene: none of them showed cerebral iron accumulation (T2-weighted images performed in all; T2 gradient-echo in 2); notably, in 1 case, iron accumulation was absent even after 18 years from disease onset on both T2 gradient-echo and susceptibility-weight MRI sequences.	Iron	208-212	fatty acid 2-hydroxylase	Homo sapiens	68-72
25647178-6	2015	HFD was associated with increased expression of the major iron uptake protein Transferrin receptor-1 (TfR-1), consistently with upregulation of the intracellular iron sensor Iron regulated protein-1 (IRP1).	Iron	58-62	transferrin receptor	Homo sapiens	78-100
25647178-6	2015	HFD was associated with increased expression of the major iron uptake protein Transferrin receptor-1 (TfR-1), consistently with upregulation of the intracellular iron sensor Iron regulated protein-1 (IRP1).	Iron	58-62	transferrin receptor	Homo sapiens	102-107
25549663-3	2015	Here we present the experimentally determined hydricity of an iron hydride complex: (SiP(iPr)3)Fe(H2)(H), DeltaGH(-) = 54.3 +- 0.9 kcal/mol [SiP(iPr)3 = [Si(o-C6H4PiPr2)3](-)].	Iron	62-74	TSSK6 activating cochaperone	Homo sapiens	85-94
25549663-3	2015	Here we present the experimentally determined hydricity of an iron hydride complex: (SiP(iPr)3)Fe(H2)(H), DeltaGH(-) = 54.3 +- 0.9 kcal/mol [SiP(iPr)3 = [Si(o-C6H4PiPr2)3](-)].	Iron	62-74	TSSK6 activating cochaperone	Homo sapiens	141-150
25549663-7	2015	Finally, the proposed mechanism of the (SiP(iPr)3)-Fe system proceeds through a monohydride intermediate (SiP(iPr)3)Fe(H2)(H), in contrast to that of the known and highly active tetraphosphinoiron, (tetraphos)Fe (tetraphos = P(o-C6H4PPh2)3), CO2 hydrogenation catalyst.	Iron	51-53	TSSK6 activating cochaperone	Homo sapiens	40-49
25832196-1	2015	Frataxin is an evolutionary conserved protein that participates in iron metabolism.	Iron	67-71	frataxin	Homo sapiens	0-8
25832196-3	2015	A number of studies indicate that frataxin binds iron and regulates Fe-S cluster biosynthesis.	Iron	49-53	frataxin	Homo sapiens	34-42
25832196-3	2015	A number of studies indicate that frataxin binds iron and regulates Fe-S cluster biosynthesis.	Iron	68-72	frataxin	Homo sapiens	34-42
25700349-5	2015	We previously discovered that the hemochromatosis protein HFE, a negative regulator of iron absorption, dampens classical MHC I antigen presentation.	Iron	87-91	homeostatic iron regulator	Homo sapiens	58-61
25647178-6	2015	HFD was associated with increased expression of the major iron uptake protein Transferrin receptor-1 (TfR-1), consistently with upregulation of the intracellular iron sensor Iron regulated protein-1 (IRP1).	Iron	162-166	transferrin receptor	Homo sapiens	78-100
25647178-6	2015	HFD was associated with increased expression of the major iron uptake protein Transferrin receptor-1 (TfR-1), consistently with upregulation of the intracellular iron sensor Iron regulated protein-1 (IRP1).	Iron	162-166	transferrin receptor	Homo sapiens	102-107
25647178-6	2015	HFD was associated with increased expression of the major iron uptake protein Transferrin receptor-1 (TfR-1), consistently with upregulation of the intracellular iron sensor Iron regulated protein-1 (IRP1).	Iron	162-166	aconitase 1	Homo sapiens	174-198
25647178-6	2015	HFD was associated with increased expression of the major iron uptake protein Transferrin receptor-1 (TfR-1), consistently with upregulation of the intracellular iron sensor Iron regulated protein-1 (IRP1).	Iron	162-166	aconitase 1	Homo sapiens	200-204
25647178-8	2015	IRP1 silencing completely abrogated TfR-1 induction and the facilitation of intracellular iron accumulation induced by fatty acids.	Iron	90-94	aconitase 1	Homo sapiens	0-4
26213099-4	2016	For the later transition metals Fe, Co, and Ni, the lowest energy (C10H8)2 M2 structures contain pentahapto-trihapto azulene ligands with an uncomplexed C=C double bond, similar to that in the long-known iron carbonyl complex (eta(5),eta(3)-C10H8)Fe2 (CO)5 .	Iron	204-208	endothelin receptor type A	Homo sapiens	26-29
25996492-4	2015	In eukaryotes, a defect in FXN results in severe defects in Fe-S cluster biogenesis, and in humans, this is associated with Friedreich"s ataxia, a neurodegenerative disease.	Iron	60-64	frataxin	Homo sapiens	27-30
26213099-5	2016	The parallel (eta(5),eta(3)-C10H8 )2M2 (M = Fe, Co, Ni) structures contain metallocene subunits with their metal atoms at long nonbonding distances of 3.5-3.9 A from the other metal atom, which is located between the azulene C7 rings.	Iron	44-46	endothelin receptor type A	Homo sapiens	14-17
25996492-5	2015	In contrast, prokaryotes deficient in the FXN homolog CyaY are fully viable, despite the clear involvement of CyaY in ISC-catalyzed Fe-S cluster formation.	Iron	132-136	frataxin	Homo sapiens	42-45
25996679-0	2015	Trading Places-Switching Frataxin Function by a Single Amino Acid Substitution within the [Fe-S] Cluster Assembly Scaffold.	Iron	91-95	frataxin	Homo sapiens	25-33
24754744-7	2015	Mean HbA2 in iron-replete betaTT was 5.4 +- 0.8 (range 3.1-7.9) and in iron-deficient betaTT was 5.4 +- 0.9 (range 3.3-7.6).	Iron	13-17	hemoglobin subunit alpha 2	Homo sapiens	5-9
24754744-8	2015	HbA2 &lt; 4.0% was found in 23/752 (3.1%) betaTT: 13/595 iron-replete (2.2%) and 10/157 (6.4%) iron-deficient betaTT individuals.	Iron	57-61	hemoglobin subunit alpha 2	Homo sapiens	0-4
26213099-6	2016	Higher energy opposed (C10H8)2 Fe2 structures contain an unprecedented distorted eta(6) ,eta(4) -azulene ligand using six carbon atoms for bonding to one iron atom as a hexahapto fulvene ligand and the remaining four carbon atoms for bonding to the other iron atom as a tetrahapto diene ligand.	Iron	154-158	endothelin receptor type A	Homo sapiens	81-84
24754744-8	2015	HbA2 &lt; 4.0% was found in 23/752 (3.1%) betaTT: 13/595 iron-replete (2.2%) and 10/157 (6.4%) iron-deficient betaTT individuals.	Iron	95-99	hemoglobin subunit alpha 2	Homo sapiens	0-4
24754744-9	2015	However, five of the 10 iron-deficient betaTT cases carried the silent CAP+1 (A&gt;C) beta-thalassemia allele accounting for the borderline HbA2%.	Iron	24-28	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	71-76
26213099-6	2016	Higher energy opposed (C10H8)2 Fe2 structures contain an unprecedented distorted eta(6) ,eta(4) -azulene ligand using six carbon atoms for bonding to one iron atom as a hexahapto fulvene ligand and the remaining four carbon atoms for bonding to the other iron atom as a tetrahapto diene ligand.	Iron	154-158	endothelin receptor type A	Homo sapiens	89-92
25972165-3	2015	NOS1AP/nNOS interaction regulates small GTPases, iron transport, p38MAPK-linked excitotoxicity, and anxiety.	Iron	49-53	nitric oxide synthase 1	Homo sapiens	7-11
26213099-6	2016	Higher energy opposed (C10H8)2 Fe2 structures contain an unprecedented distorted eta(6) ,eta(4) -azulene ligand using six carbon atoms for bonding to one iron atom as a hexahapto fulvene ligand and the remaining four carbon atoms for bonding to the other iron atom as a tetrahapto diene ligand.	Iron	255-259	endothelin receptor type A	Homo sapiens	81-84
26213099-6	2016	Higher energy opposed (C10H8)2 Fe2 structures contain an unprecedented distorted eta(6) ,eta(4) -azulene ligand using six carbon atoms for bonding to one iron atom as a hexahapto fulvene ligand and the remaining four carbon atoms for bonding to the other iron atom as a tetrahapto diene ligand.	Iron	255-259	endothelin receptor type A	Homo sapiens	89-92
27303693-5	2016	This analysis revealed repression of MIG1 by HapX and activation of HAPX by Mig1 under low-iron conditions and Mig1 regulation of mitochondrial functions, including respiration, tolerance for reactive oxygen species, and expression of genes for iron consumption and iron acquisition functions.	Iron	245-249	transcription factor MIG1	Saccharomyces cerevisiae S288C	111-115
25788583-0	2015	Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.	Iron	69-73	hephaestin	Mus musculus	0-10
25788583-4	2015	OBJECTIVE: The aim was to study the role of hephaestin (HEPH) and ceruloplasmin (CP) in CNS iron metabolism and homeostasis.	Iron	92-96	hephaestin	Mus musculus	44-54
25788583-4	2015	OBJECTIVE: The aim was to study the role of hephaestin (HEPH) and ceruloplasmin (CP) in CNS iron metabolism and homeostasis.	Iron	92-96	hephaestin	Mus musculus	56-60
25652229-13	2015	We conclude that iron increases turnover of IRP-1 in kidney cells, while increasing aconitase activity, suggesting that the apoprotein (aconitase-inactive) form is not exclusively responsible for turnover.	Iron	17-21	aconitase 1	Rattus norvegicus	44-49
25652229-15	2015	IRP-1 protein levels are not regulated by ROS, but IRP-1-dependent ferritin expression may decrease ROS and increase total glutathione levels, suggesting that ferritin levels are more important than citrate metabolism in protecting renal cells against iron.	Iron	252-256	aconitase 1	Rattus norvegicus	51-56
25496563-0	2015	Iron nanoparticle-induced activation of plasma membrane H(+)-ATPase promotes stomatal opening in Arabidopsis thaliana.	Iron	0-4	plasma membrane H+-ATPase	Arabidopsis thaliana	40-67
25496563-3	2015	The current investigation found that exposure of Arabidopsis thaliana to nano zerovalent iron (nZVI) triggered high plasma membrane H(+)-ATPase activity.	Iron	89-93	plasma membrane H+-ATPase	Arabidopsis thaliana	116-143
28962376-0	2015	Effect of iron overload on furin expression in wild-type and beta-thalassemic mice.	Iron	10-14	furin (paired basic amino acid cleaving enzyme)	Mus musculus	27-32
27303693-5	2016	This analysis revealed repression of MIG1 by HapX and activation of HAPX by Mig1 under low-iron conditions and Mig1 regulation of mitochondrial functions, including respiration, tolerance for reactive oxygen species, and expression of genes for iron consumption and iron acquisition functions.	Iron	245-249	transcription factor MIG1	Saccharomyces cerevisiae S288C	111-115
28962376-5	2015	However, the effect of iron overload on furin, a post-translational regulator of hepcidin, has never been evaluated.	Iron	23-27	furin (paired basic amino acid cleaving enzyme)	Mus musculus	40-45
26652036-1	2016	The two isoforms of human heme oxygenase (HO1 and HO2) catalyze oxidative degradation of heme to biliverdin, Fe, and CO.	Iron	109-111	heme oxygenase 2	Homo sapiens	50-53
28962376-6	2015	The present study aimed to investigate the changes in furin and related factors in parenteral iron-overloaded mice, including those with beta-thalassemia.	Iron	94-98	furin (paired basic amino acid cleaving enzyme)	Mus musculus	54-59
28962376-8	2015	In the iron overload condition, our data demonstrated a significant Furin mRNA reduction in WT and th3/+ mice.	Iron	7-11	furin (paired basic amino acid cleaving enzyme)	Mus musculus	68-73
28962376-9	2015	In addition, the liver furin protein level in iron-overloaded WT mice was significantly reduced by 70% compared to control WT mice.	Iron	46-50	furin (paired basic amino acid cleaving enzyme)	Mus musculus	23-28
28962376-10	2015	However, the liver furin protein in iron-overloaded th3/+ mice did not show a significant reduction compared to control th3/+ mice.	Iron	36-40	furin (paired basic amino acid cleaving enzyme)	Mus musculus	19-24
25880808-8	2015	We found an increased expression of S100a8 and S100a9 that is most pronounced in high iron diet conditions.	Iron	86-90	S100 calcium binding protein A8	Homo sapiens	36-42
25860887-5	2015	With manipulation of dietary iron in wild-type mice, Bmp6 and Tfr1 expression in both HCs and NPCs was inversely related, as expected.	Iron	29-33	transferrin receptor	Mus musculus	62-66
25398879-6	2015	Importantly, we have identified the (35)S-labeled persulfide on the NFS1 cysteine desulfurase as a genuine intermediate en route to Fe-S cluster synthesis.	Iron	132-136	NFS1 cysteine desulfurase	Homo sapiens	68-72
26517689-7	2016	Altogether, targeting BNIP3L in wild-type p53 colon cancer cells is a novel anticancer strategy activating iron depletion signaling and the mitophagy-related cell death pathway.	Iron	107-111	BCL2 interacting protein 3 like	Homo sapiens	22-28
25398879-7	2015	In physiological settings, the persulfide sulfur is released from NFS1 and transferred to a scaffold protein, where it combines with iron to form an Fe-S cluster intermediate.	Iron	133-137	NFS1 cysteine desulfurase	Homo sapiens	66-70
25398879-7	2015	In physiological settings, the persulfide sulfur is released from NFS1 and transferred to a scaffold protein, where it combines with iron to form an Fe-S cluster intermediate.	Iron	149-151	NFS1 cysteine desulfurase	Homo sapiens	66-70
25398879-8	2015	We found that the release of persulfide sulfur from NFS1 requires iron, showing that the use of iron and sulfur for the synthesis of Fe-S cluster intermediates is a highly coordinated process.	Iron	66-70	NFS1 cysteine desulfurase	Homo sapiens	52-56
25398879-8	2015	We found that the release of persulfide sulfur from NFS1 requires iron, showing that the use of iron and sulfur for the synthesis of Fe-S cluster intermediates is a highly coordinated process.	Iron	96-100	NFS1 cysteine desulfurase	Homo sapiens	52-56
25398879-8	2015	We found that the release of persulfide sulfur from NFS1 requires iron, showing that the use of iron and sulfur for the synthesis of Fe-S cluster intermediates is a highly coordinated process.	Iron	133-135	NFS1 cysteine desulfurase	Homo sapiens	52-56
25550467-6	2015	Although iron in excess, known to increase reactive oxygen species production, and iron depletion both resulted in decreased ACO1 mRNA levels and activity, Aco1 KD led to reduced gene expression of transferrin receptor (Tfrc) and transferrin, disrupting intracellular iron uptake.	Iron	83-87	aconitase 1	Homo sapiens	125-129
25550467-6	2015	Although iron in excess, known to increase reactive oxygen species production, and iron depletion both resulted in decreased ACO1 mRNA levels and activity, Aco1 KD led to reduced gene expression of transferrin receptor (Tfrc) and transferrin, disrupting intracellular iron uptake.	Iron	83-87	aconitase 1	Homo sapiens	156-160
25205713-1	2015	Matriptase-2 is a type II transmembrane serine protease controlling the expression of hepcidin, the key regulator of iron homeostasis.	Iron	117-121	transmembrane serine protease 6	Mus musculus	0-12
26728034-1	2016	BACKGROUND: Mitochondria play essential biological functions including the synthesis and trafficking of porphyrins and iron/sulfur clusters (ISC), processes that in mammals involve the mitochondrial ATP-Binding Cassette (ABC) transporters ABCB6 and ABCB7, respectively.	Iron	119-123	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	239-244
25654085-0	2015	HFE genotyping in patients with elevated serum iron indices and liver diseases.	Iron	47-51	homeostatic iron regulator	Homo sapiens	0-3
27708207-1	2016	Neutrophil gelatinase-associated lipocalin, known also as 24p3 lipocalin, lipocalin-2 or uterocalin (in mouse), is a small secretory protein binding small molecular weight ligands which takes part in numerous processes including apoptosis induction in leukocytes, iron transport, smell, and prostaglandins and retinol transport [19].	Iron	264-268	lipocalin 2	Mus musculus	0-42
25732555-5	2015	In several pathological conditions in which free heme-Fe levels increase, the buffering capacity of plasma hemopexin is overwhelmed and most of heme-Fe binds to the fatty acid site 1 of HSA.	Iron	54-56	hemopexin	Homo sapiens	107-116
27708207-1	2016	Neutrophil gelatinase-associated lipocalin, known also as 24p3 lipocalin, lipocalin-2 or uterocalin (in mouse), is a small secretory protein binding small molecular weight ligands which takes part in numerous processes including apoptosis induction in leukocytes, iron transport, smell, and prostaglandins and retinol transport [19].	Iron	264-268	lipocalin 2	Mus musculus	74-85
26820393-1	2016	BACKGROUND/AIMS: Hemoglobin H (HbH) disease is associated with iron overload, but whether this results in serious cardiac or vascular sequelae is unresolved.	Iron	63-67	hemoglobin subunit alpha 1	Homo sapiens	17-29
26416321-1	2015	Hereditary hemochromatosis is caused by a potentially lethal recessive gene (HFE, C282Y allele) that increases iron absorption and reaches polymorphic levels in northern European populations.	Iron	111-115	homeostatic iron regulator	Homo sapiens	77-80
26416321-2	2015	Because persons carrying the allele absorb iron more readily than do noncarriers, it has often been suggested that HFE is an adaptation to anemia.	Iron	43-47	homeostatic iron regulator	Homo sapiens	115-118
26416321-3	2015	We hypothesize positive selection for HFE began during or after the European Neolithic with the adoption of an iron-deficient high-grain and dairying diet and consequent anemia, a finding confirmed in Neolithic and later European skeletons.	Iron	111-115	homeostatic iron regulator	Homo sapiens	38-41
26820393-1	2016	BACKGROUND/AIMS: Hemoglobin H (HbH) disease is associated with iron overload, but whether this results in serious cardiac or vascular sequelae is unresolved.	Iron	63-67	hemoglobin subunit alpha 1	Homo sapiens	31-34
24854990-6	2015	We found higher iron levels in SF3B1 mutant vs WT RARS/-T by transmission electron microscopy/spectroscopy/flow cytometry.	Iron	16-20	splicing factor 3b subunit 1	Homo sapiens	31-36
24854990-7	2015	SF3B1 mutations led to increased iron without changing the valence as shown by the presence of Fe(2+) in mutant and WT.	Iron	33-37	splicing factor 3b subunit 1	Homo sapiens	0-5
27170390-2	2016	Molecular and clinical genetic studies have led to the identification of genes other than HFE in patients with inherited diseases associated with increased hepatic iron storage that can cause hemochromatosis, which adds complexity to a diagnostic approach to patients with suspected hemochromatosis.	Iron	164-168	homeostatic iron regulator	Homo sapiens	90-93
24854990-10	2015	Our studies suggest that SF3B1 mutations contribute to cellular iron overload in RARS/-T by deregulating SLC25A37.	Iron	64-68	splicing factor 3b subunit 1	Homo sapiens	25-30
26170532-3	2015	Recently, it was reported that the new ubiquitin ligase complex termed linear ubiquitin chain assembly complex (LUBAC), composed of SHARPIN (SHANK-associated RH domain-interacting protein), HOIL-1L (longer isoform of heme-oxidized iron-regulatory protein 2 ubiquitin ligase-1), and HOIP (HOIL-1L interacting protein), forms linear ubiquitin on NF-kappaB essential modulator (NEMO) and thereby induces NF-kappaB pathway activation.	Iron	231-235	SHANK-associated RH domain interacting protein	Mus musculus	141-187
26405152-0	2016	Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia.	Iron	98-102	transmembrane serine protease 6	Mus musculus	15-22
25485540-1	2014	Chlamydomonas reinhardtii fox1 gene encodes a ferroxidase that is involved in cellular Fe uptake and highly induced during Fe deficient conditions.	Iron	87-89	uncharacterized protein	Chlamydomonas reinhardtii	26-30
25485540-1	2014	Chlamydomonas reinhardtii fox1 gene encodes a ferroxidase that is involved in cellular Fe uptake and highly induced during Fe deficient conditions.	Iron	123-125	uncharacterized protein	Chlamydomonas reinhardtii	26-30
26873085-0	2016	Non-HFE iron overload as a surrogate marker of disease severity in patients of liver cirrhosis.	Iron	8-12	homeostatic iron regulator	Homo sapiens	4-7
25520556-0	2014	Evidence for the Influence of the Iron Regulatory MHC Class I Molecule HFE on Tumor Progression in Experimental Models and Clinical Populations.	Iron	34-38	homeostatic iron regulator	Homo sapiens	71-74
25520556-2	2014	Of these, the HFE protein (high iron gene and its protein product) is of particular interest because of its interaction with both iron handling and immune function and the high rate of genetic polymorphisms resulting in a mutant protein.	Iron	32-36	homeostatic iron regulator	Homo sapiens	14-17
25520556-2	2014	Of these, the HFE protein (high iron gene and its protein product) is of particular interest because of its interaction with both iron handling and immune function and the high rate of genetic polymorphisms resulting in a mutant protein.	Iron	130-134	homeostatic iron regulator	Homo sapiens	14-17
25520556-5	2014	In particular, putative mechanisms exist for HFE to affect tumor progression through its role in iron handling and its major histocompatibility complex class I structural features.	Iron	97-101	homeostatic iron regulator	Homo sapiens	45-48
26873085-3	2016	This study was aimed to evaluate the association of iron overload and disease severity in patients of liver cirrhosis and its association with HFE gene mutation.	Iron	52-56	homeostatic iron regulator	Homo sapiens	143-146
27123357-1	2016	Mutations in the HFE gene may be associated with increased tissue iron stores reflected in an elevated serum ferritin.	Iron	66-70	homeostatic iron regulator	Homo sapiens	17-20
25220979-9	2014	Transferrin receptor 1 and divalent metal transporter 1 were more highly expressed in females than males (p &lt; 0.01 and p &lt; 0.0001, respectively), consistent with their lower cardiac iron levels, as predicted by IRE/IRP regulatory pathways.	Iron	188-192	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	27-55
26840933-3	2016	We describe a 71-year-old female and a 62-year-old male patient, both of whom had several risk factors for developing PCT, ranging from iron overload due to a mutation in the hereditary haemochromatosis protein (HFE) gene, alcohol use, smoking, and exogenous oestrogen, to persistent hepatitis C infection.	Iron	136-140	homeostatic iron regulator	Homo sapiens	212-215
25404782-9	2014	The electronic properties of the bis-phosphinite PONOP and bis-phosphite PONOP iron complexes are intermediate between previously reported PNP and PDI iron complexes, with the PONOP ligands exhibiting stronger electron donating ability than PDI ligands, but promoting a less electron rich metal center than found in analogous PNP iron complexes.	Iron	79-83	prolyl 4-hydroxylase subunit beta	Homo sapiens	147-150
25404782-9	2014	The electronic properties of the bis-phosphinite PONOP and bis-phosphite PONOP iron complexes are intermediate between previously reported PNP and PDI iron complexes, with the PONOP ligands exhibiting stronger electron donating ability than PDI ligands, but promoting a less electron rich metal center than found in analogous PNP iron complexes.	Iron	79-83	prolyl 4-hydroxylase subunit beta	Homo sapiens	241-244
25404782-9	2014	The electronic properties of the bis-phosphinite PONOP and bis-phosphite PONOP iron complexes are intermediate between previously reported PNP and PDI iron complexes, with the PONOP ligands exhibiting stronger electron donating ability than PDI ligands, but promoting a less electron rich metal center than found in analogous PNP iron complexes.	Iron	151-155	prolyl 4-hydroxylase subunit beta	Homo sapiens	147-150
25404782-9	2014	The electronic properties of the bis-phosphinite PONOP and bis-phosphite PONOP iron complexes are intermediate between previously reported PNP and PDI iron complexes, with the PONOP ligands exhibiting stronger electron donating ability than PDI ligands, but promoting a less electron rich metal center than found in analogous PNP iron complexes.	Iron	151-155	prolyl 4-hydroxylase subunit beta	Homo sapiens	147-150
26460247-7	2015	The results replicate the association of SNPs with iron-related traits, and also confirm the protective effect of both A allele of rs1800562 (HFE) and G allele of rs4895441 (HBS1L-MYB).	Iron	51-55	homeostatic iron regulator	Homo sapiens	142-145
25385697-8	2014	Further, meristem size is also decreased in response to Fe excess in ferritin mutant plants, implicating cell cycle arrest mediated by the ROS-activated SMR5/SMR7 cyclin-dependent kinase inhibitors pathway in the interaction between Fe and RSA.	Iron	56-58	hypothetical protein	Arabidopsis thaliana	153-157
25385697-8	2014	Further, meristem size is also decreased in response to Fe excess in ferritin mutant plants, implicating cell cycle arrest mediated by the ROS-activated SMR5/SMR7 cyclin-dependent kinase inhibitors pathway in the interaction between Fe and RSA.	Iron	233-235	hypothetical protein	Arabidopsis thaliana	153-157
26460254-0	2015	A coding polymorphism in the BMP2 gene is associated with iron overload in non-HFE haemochromatosis patients.	Iron	58-62	bone morphogenetic protein 2	Homo sapiens	29-33
26208779-7	2015	The activities of mitochondrial complex I and II were both significantly impaired by the absence of MnSOD activity, presumably from disruption of the Fe/S centers in NADH dehydrogenase and succinate dehydrogenase subunit B by the aberrant redox state in the mitochondrial matrix of SOD2-null cells.	Iron	150-152	superoxide dismutase 2	Homo sapiens	100-105
25540010-4	2014	Colorimetric and immunoturbidimetric methods were used to determine the concentrations of plasma iron and the proteins involved in its metabolism - ceruloplasmin, transferrin, and ferritin.	Iron	97-101	ceruloplasmin	Rattus norvegicus	148-161
26456054-0	2015	The iron-sulfur cluster assembly network component NARFL is a key element in the cellular defense against oxidative stress.	Iron	4-8	cytosolic iron-sulfur assembly component 3	Homo sapiens	51-56
24889971-1	2014	Iron uptake by the transferrin (Tf)-transferrin receptor (TfR) complex is critical for erythroid differentiation.	Iron	0-4	transferrin receptor	Homo sapiens	58-61
24889971-9	2014	We offer novel insight of Dab2 function in iron uptake and TfR internalization for the suspended culture of hematopoietic lineage cells.	Iron	43-47	DAB adaptor protein 2	Homo sapiens	26-30
26456054-4	2015	The driver gene of this amplification was identified by functional studies as NARFL, which encodes a component of the cytosolic iron-sulfur cluster assembly system.	Iron	128-132	cytosolic iron-sulfur assembly component 3	Homo sapiens	78-83
25158131-0	2014	p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron.	Iron	153-157	frataxin	Homo sapiens	54-62
25158131-1	2014	Mitochondrial frataxin functions in iron homeostasis, biogenesis of iron-sulfur clusters, protection from oxidative stress and apoptosis, and as a tumor suppressor protein.	Iron	36-40	frataxin	Homo sapiens	14-22
25158131-1	2014	Mitochondrial frataxin functions in iron homeostasis, biogenesis of iron-sulfur clusters, protection from oxidative stress and apoptosis, and as a tumor suppressor protein.	Iron	68-72	frataxin	Homo sapiens	14-22
25158131-7	2014	Finally, when the HeLa cells overexpressing frataxin were treated with 5-aminolevulinic acid (ALA), there was less accumulation of protoporphyrin than HeLa control cells, and it was sharply decreased by the addition of iron citrate, suggesting that the utilization of mitochondrial iron for heme biosynthesis can be dependent on the level of frataxin.	Iron	219-223	frataxin	Homo sapiens	44-52
25158131-7	2014	Finally, when the HeLa cells overexpressing frataxin were treated with 5-aminolevulinic acid (ALA), there was less accumulation of protoporphyrin than HeLa control cells, and it was sharply decreased by the addition of iron citrate, suggesting that the utilization of mitochondrial iron for heme biosynthesis can be dependent on the level of frataxin.	Iron	219-223	frataxin	Homo sapiens	342-350
26456054-5	2015	In line with this result we found the cytosolic c-aconitase activity as well as the nuclear protein RTEL1, both Fe-S dependent proteins, to be protected by NARFL overexpression under hyperoxia.	Iron	112-114	regulator of telomere elongation helicase 1	Homo sapiens	100-105
25158131-8	2014	Alternatively, the low expression of frataxin not regulated by p53 in tumor cells lowers the utilization of iron in mitochondria, causing the tumor-specific ALA-induced accumulation of protoporphyrin.	Iron	108-112	frataxin	Homo sapiens	37-45
26456054-5	2015	In line with this result we found the cytosolic c-aconitase activity as well as the nuclear protein RTEL1, both Fe-S dependent proteins, to be protected by NARFL overexpression under hyperoxia.	Iron	112-114	cytosolic iron-sulfur assembly component 3	Homo sapiens	156-161
26303407-0	2015	Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.	Iron	25-29	hephaestin	Mus musculus	3-7
25190478-8	2014	A single point mutation (T-A) in exon 8 of Lox2 changed histidine (H532, one of the iron-binding ligands essential for Lox2 activity) to glutamine.	Iron	84-88	seed linoleate 9S-lipoxygenase-2	Glycine max	43-47
25190478-8	2014	A single point mutation (T-A) in exon 8 of Lox2 changed histidine (H532, one of the iron-binding ligands essential for Lox2 activity) to glutamine.	Iron	84-88	seed linoleate 9S-lipoxygenase-2	Glycine max	119-123
26303407-12	2015	Below: In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels.	Iron	45-49	hephaestin	Mus musculus	39-43
26303407-12	2015	Below: In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels.	Iron	94-98	hephaestin	Mus musculus	39-43
25360591-8	2014	The seed Fe concentration in the nramp3/nramp4 mutant overexpressing AtVTL1, AtVTL2 or AtVTL5 was between 50 and 60% higher than in non-transformed double mutants or wild-type plants.	Iron	9-11	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	69-75
26468517-0	2015	Auxin Resistant1 and PIN-FORMED2 Protect Lateral Root Formation in Arabidopsis under Iron Stress.	Iron	85-89	Auxin efflux carrier family protein	Arabidopsis thaliana	21-32
25356756-7	2014	Raman spectroscopy analysis and immunoblotting indicated that in mitochondria from SSQ1 and ISA1 mutants, the content of [Fe-S] centers was decreased, as was formation of Rieske protein-dependent supercomplex III2IV2, but this was not observed in the iron-deficient ATX1 and MRS4 mutants.	Iron	251-255	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	92-96
26468517-4	2015	Furthermore, Fe stress significantly reduced PIN-FORMED2 (PIN2)-green fluorescent protein (GFP) expression in root tips, and pin2-1 mutants exhibited significantly fewer LR initiation events under excess Fe than the wild type.	Iron	13-15	Auxin efflux carrier family protein	Arabidopsis thaliana	45-56
26468517-4	2015	Furthermore, Fe stress significantly reduced PIN-FORMED2 (PIN2)-green fluorescent protein (GFP) expression in root tips, and pin2-1 mutants exhibited significantly fewer LR initiation events under excess Fe than the wild type.	Iron	13-15	Auxin efflux carrier family protein	Arabidopsis thaliana	58-62
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	homeostatic iron regulator	Homo sapiens	100-103
26468517-4	2015	Furthermore, Fe stress significantly reduced PIN-FORMED2 (PIN2)-green fluorescent protein (GFP) expression in root tips, and pin2-1 mutants exhibited significantly fewer LR initiation events under excess Fe than the wild type.	Iron	204-206	Auxin efflux carrier family protein	Arabidopsis thaliana	125-129
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	transferrin receptor	Homo sapiens	124-128
26468517-5	2015	Exogenous application of both Fe and glutathione together increased PIN2-GFP expression and the number of LR initiation events compared with Fe treatment alone.	Iron	30-32	Auxin efflux carrier family protein	Arabidopsis thaliana	68-72
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	57-59	Auxin efflux carrier family protein	Arabidopsis thaliana	70-74
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	57-59	Auxin efflux carrier family protein	Arabidopsis thaliana	194-198
26877837-16	2015	The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.	Iron	149-153	homeostatic iron regulator	Homo sapiens	31-34
25106854-1	2014	Iron regulatory protein-1 (IRP-1) is central to regulation of iron homeostasis, and has been shown to be sensitive to Cd(2+) in vitro.	Iron	62-66	aconitase 1	Homo sapiens	0-25
25106854-1	2014	Iron regulatory protein-1 (IRP-1) is central to regulation of iron homeostasis, and has been shown to be sensitive to Cd(2+) in vitro.	Iron	62-66	aconitase 1	Homo sapiens	27-32
25106854-2	2014	Although Cd(2+) induces disulfide-bond formation in many proteins, the critical cysteine residues for iron binding in IRP-1 were shown not to be involved in Cd-induced IRP-1 aggregation in vitro.	Iron	102-106	aconitase 1	Homo sapiens	118-123
25106854-9	2014	Polymer-dependent translocation of IRP-1 in Cd(2+)-exposed cells may underlie effects of Cd(2+) on iron homeostasis.	Iron	99-103	aconitase 1	Homo sapiens	35-40
26575645-11	2015	Expression of iron-responsive genes involved in myelination (myelin basic protein (Mbp) and proteolipid protein 2 (Plp2)) was downregulated in infected mice (p = 0.001 and p = 0.02).	Iron	14-18	myelin basic protein	Mus musculus	61-81
25062827-0	2014	Reactive oxygen species regulates expression of iron-sulfur cluster assembly protein IscS of Leishmania donovani.	Iron	48-52	NFS1 cysteine desulfurase	Homo sapiens	85-89
25062827-1	2014	The cysteine desulfurase, IscS, is a highly conserved and essential component of the mitochondrial iron-sulfur cluster (ISC) system that serves as a sulfur donor for Fe-S clusters biogenesis.	Iron	99-103	NFS1 cysteine desulfurase	Homo sapiens	26-30
25062827-1	2014	The cysteine desulfurase, IscS, is a highly conserved and essential component of the mitochondrial iron-sulfur cluster (ISC) system that serves as a sulfur donor for Fe-S clusters biogenesis.	Iron	166-170	NFS1 cysteine desulfurase	Homo sapiens	26-30
25224679-1	2014	BACKGROUND: Ceruloplasmin is a ferroxidase expressed in the central nervous system both as soluble form in the cerebrospinal fluid (CSF) and as membrane-bound GPI-anchored isoform on astrocytes, where it plays a role in iron homeostasis and antioxidant defense.	Iron	220-224	ceruloplasmin	Rattus norvegicus	12-25
26575645-11	2015	Expression of iron-responsive genes involved in myelination (myelin basic protein (Mbp) and proteolipid protein 2 (Plp2)) was downregulated in infected mice (p = 0.001 and p = 0.02).	Iron	14-18	myelin basic protein	Mus musculus	83-86
26575645-11	2015	Expression of iron-responsive genes involved in myelination (myelin basic protein (Mbp) and proteolipid protein 2 (Plp2)) was downregulated in infected mice (p = 0.001 and p = 0.02).	Iron	14-18	proteolipid protein 2	Mus musculus	92-113
26575645-11	2015	Expression of iron-responsive genes involved in myelination (myelin basic protein (Mbp) and proteolipid protein 2 (Plp2)) was downregulated in infected mice (p = 0.001 and p = 0.02).	Iron	14-18	proteolipid protein 2	Mus musculus	115-119
25201874-4	2014	We found that mTORC1 activity in RBCs is regulated by dietary iron and that genetic activation or inhibition of mTORC1 results in macrocytic or microcytic anemia, respectively.	Iron	62-66	CREB regulated transcription coactivator 1	Mus musculus	14-20
26321457-2	2015	The protein product of FXN is a nuclear-encoded mitochondrial protein required for the biogenesis of iron- clusters (Fe-S).	Iron	101-105	frataxin	Homo sapiens	23-26
24880337-0	2014	OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds.	Iron	27-31	oligopeptide transporter	Arabidopsis thaliana	0-4
26321457-2	2015	The protein product of FXN is a nuclear-encoded mitochondrial protein required for the biogenesis of iron- clusters (Fe-S).	Iron	117-121	frataxin	Homo sapiens	23-26
24880337-4	2014	The opt3-2 mutant constitutively up-regulates the Fe/Zn/Cd transporter IRT1 and FRO2 in roots, indicative of an iron-deficiency response.	Iron	112-116	oligopeptide transporter	Arabidopsis thaliana	4-8
26209973-1	2015	KEY MESSAGE: Overexpression of the iron transporter NtPIC1 increases iron concentration in shoots and reduces Cd uptake/accumulation in plants, mediating tolerance to cadmium.	Iron	35-39	protein TIC 21, chloroplastic-like	Nicotiana tabacum	52-58
24880337-6	2014	Interestingly, shoot-specific expression of OPT3 rescues the Cd sensitivity and complements the aberrant expression of IRT1 in opt3-2 roots, suggesting that OPT3 is required to relay the iron status from leaves to roots.	Iron	187-191	oligopeptide transporter	Arabidopsis thaliana	44-48
24880337-6	2014	Interestingly, shoot-specific expression of OPT3 rescues the Cd sensitivity and complements the aberrant expression of IRT1 in opt3-2 roots, suggesting that OPT3 is required to relay the iron status from leaves to roots.	Iron	187-191	oligopeptide transporter	Arabidopsis thaliana	127-131
24880337-6	2014	Interestingly, shoot-specific expression of OPT3 rescues the Cd sensitivity and complements the aberrant expression of IRT1 in opt3-2 roots, suggesting that OPT3 is required to relay the iron status from leaves to roots.	Iron	187-191	oligopeptide transporter	Arabidopsis thaliana	157-161
24880337-8	2014	Using radioisotope experiments, we found that mobilization of Fe from leaves is severely affected in opt3-2, suggesting that Fe mobilization out of leaves is required for proper trace-metal homeostasis.	Iron	62-64	oligopeptide transporter	Arabidopsis thaliana	101-105
24880337-8	2014	Using radioisotope experiments, we found that mobilization of Fe from leaves is severely affected in opt3-2, suggesting that Fe mobilization out of leaves is required for proper trace-metal homeostasis.	Iron	125-127	oligopeptide transporter	Arabidopsis thaliana	101-105
24880337-10	2014	Our in planta results show that OPT3 is important for leaf phloem-loading of iron and plays a key role regulating Fe, Zn, and Cd distribution within the plant.	Iron	77-81	oligopeptide transporter	Arabidopsis thaliana	32-36
25815883-9	2015	Taken all together, our data indicate that, in our experimental model, FHC silencing may affect RAF1/pERK1/2 levels through the modulation of a specific set of miRNAs and add new insights in to the relationship among iron homeostasis and miRNAs.	Iron	217-221	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	96-100
25687725-3	2015	The compound displays a high affinity and selectivity for iron(III) as demonstrated by the log beta2 = 33.39 +- 0.03 and the pFe(3+) value of 22.3.	Iron	58-62	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	95-100
25890235-4	2015	Using neutrophils isolated from the knock-in mice, we identified several PKCdelta substrates, one of which was lipocalin-2 (LCN2), which is an iron-binding protein that can trigger apoptosis by reducing intracellular iron concentrations.	Iron	143-147	lipocalin 2	Mus musculus	124-128
25890235-4	2015	Using neutrophils isolated from the knock-in mice, we identified several PKCdelta substrates, one of which was lipocalin-2 (LCN2), which is an iron-binding protein that can trigger apoptosis by reducing intracellular iron concentrations.	Iron	217-221	lipocalin 2	Mus musculus	111-122
24880337-10	2014	Our in planta results show that OPT3 is important for leaf phloem-loading of iron and plays a key role regulating Fe, Zn, and Cd distribution within the plant.	Iron	114-116	oligopeptide transporter	Arabidopsis thaliana	32-36
25890235-4	2015	Using neutrophils isolated from the knock-in mice, we identified several PKCdelta substrates, one of which was lipocalin-2 (LCN2), which is an iron-binding protein that can trigger apoptosis by reducing intracellular iron concentrations.	Iron	217-221	lipocalin 2	Mus musculus	124-128
26209973-3	2015	NtPIC1 (Permease In Chloroplast1) is an Fe transporter protein in tobacco, required for Fe homeostasis.	Iron	40-42	protein TIC 21, chloroplastic-like	Nicotiana tabacum	0-6
26209973-7	2015	Importantly, NtPIC1-OE plants had higher Fe concentrations in shoots and lower Fe concentrations in roots, and Cd concentrations in NtPIC1-OE plants were significantly lower compared to those in WT plants.	Iron	41-43	protein TIC 21, chloroplastic-like	Nicotiana tabacum	13-19
26209973-7	2015	Importantly, NtPIC1-OE plants had higher Fe concentrations in shoots and lower Fe concentrations in roots, and Cd concentrations in NtPIC1-OE plants were significantly lower compared to those in WT plants.	Iron	79-81	protein TIC 21, chloroplastic-like	Nicotiana tabacum	13-19
24958100-0	2014	Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiency.	Iron	83-87	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	6-10
24958100-0	2014	Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiency.	Iron	83-87	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	63-67
26209973-8	2015	Moreover, Fe transport-related genes (NtPIC1, NtNRAMP1, and NtFER1) were upregulated in NtPIC1-OE plants, while Fe deficiency-related genes (NtFRO1, NtIRT1, and NtZIP1) that mediate Cd uptake were downregulated.	Iron	10-12	protein TIC 21, chloroplastic-like	Nicotiana tabacum	38-44
24958100-4	2014	The decline of Sml1 protein levels upon Fe starvation depends on Dun1 forkhead-associated and kinase domains, the 26S proteasome, and the vacuolar proteolytic pathway.	Iron	40-42	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	15-19
24958100-4	2014	The decline of Sml1 protein levels upon Fe starvation depends on Dun1 forkhead-associated and kinase domains, the 26S proteasome, and the vacuolar proteolytic pathway.	Iron	40-42	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	65-69
24958100-5	2014	Depletion of core components of the mitochondrial iron-sulfur cluster assembly leads to a Dun1-dependent diminution of Sml1 protein levels.	Iron	50-54	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	90-94
24958100-5	2014	Depletion of core components of the mitochondrial iron-sulfur cluster assembly leads to a Dun1-dependent diminution of Sml1 protein levels.	Iron	50-54	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	119-123
24958100-9	2014	Taken together, these results reveal that the Dun1 checkpoint kinase promotes RNR function in response to Fe starvation by stimulating Sml1 protein degradation.	Iron	106-108	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	46-50
25526737-7	2015	SR, especially high-energy (56)Fe or (28)Si ions markedly decreased sphingosine-1-phosphate levels and Akt- and p38 MAPK phosphorylation, depleted anti-senescence sirtuin-1 and increased biochemical markers of autophagy.	Iron	31-33	mitogen-activated protein kinase 14	Mus musculus	112-115
25485477-5	2015	The cyt c/H2O2-induced liposome leakage was abolished by cyanide presumably competing with H2O2 for coordination with the central iron atom of the heme in cyt c.	Iron	130-134	HEME	Bos taurus	147-151
24958100-9	2014	Taken together, these results reveal that the Dun1 checkpoint kinase promotes RNR function in response to Fe starvation by stimulating Sml1 protein degradation.	Iron	106-108	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	135-139
26209973-8	2015	Moreover, Fe transport-related genes (NtPIC1, NtNRAMP1, and NtFER1) were upregulated in NtPIC1-OE plants, while Fe deficiency-related genes (NtFRO1, NtIRT1, and NtZIP1) that mediate Cd uptake were downregulated.	Iron	10-12	metal transporter Nramp6-like	Nicotiana tabacum	46-54
26359661-16	2015	In conclusion, our results indicate that the electron richness of the Fe2 core influences DeltaE t-H-mu-H, provided that (i) the R size of PR3 must be greater than that of Me and (ii) an electron donor must be bound to Fe apically.	Iron	70-72	proteinase 3	Homo sapiens	139-142
24327207-0	2014	Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells.	Iron	38-42	frataxin	Homo sapiens	12-29
25491948-1	2015	The HFE (high iron) protein plays a key role in the regulation of body iron.	Iron	14-18	homeostatic iron regulator	Homo sapiens	4-7
25491948-1	2015	The HFE (high iron) protein plays a key role in the regulation of body iron.	Iron	71-75	homeostatic iron regulator	Homo sapiens	4-7
26517908-4	2015	In particular, ABC subfamily B member 7 (ABCB7) and its homologues in yeast and plants are required for iron-sulfur (Fe-S) cluster biosynthesis outside of the mitochondria, whereas ABCB10 is involved in haem biosynthesis.	Iron	117-121	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	15-18
25557118-0	2015	Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms.	Iron	97-101	lipocalin 2	Rattus norvegicus	0-11
25557118-6	2015	Co-treatment with a radical scavenger (U83836E), a Nox inhibitor (apocynin) and an iron chelating agent (deferiprone) significantly dampened the ability of LCN2 to enhance tube formation and scratch migration in brain endothelial cells.	Iron	83-87	lipocalin 2	Rattus norvegicus	156-160
25557118-7	2015	These findings provide in vitro proof of the concept that LCN2 can promote angiogenesis via iron- and reactive oxygen species-related pathways, and support the idea that LCN2 may contribute to the neurovascular recovery aspects of inflammation.	Iron	92-96	lipocalin 2	Rattus norvegicus	58-62
24327207-1	2014	Friedreich ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is due to GAA repeat expansions within the first intron of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	249-253	frataxin	Homo sapiens	0-17
24327207-1	2014	Friedreich ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is due to GAA repeat expansions within the first intron of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	249-253	frataxin	Homo sapiens	19-23
24327207-1	2014	Friedreich ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is due to GAA repeat expansions within the first intron of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	249-253	frataxin	Homo sapiens	182-190
24327207-1	2014	Friedreich ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is due to GAA repeat expansions within the first intron of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	249-253	frataxin	Homo sapiens	192-195
25557118-10	2015	LCN2 promoted tube formation and migration via iron and ROS-related pathways in rat brain endothelial cells.	Iron	47-51	lipocalin 2	Rattus norvegicus	0-4
25557118-11	2015	ROS scavengers, Nox inhibitors and iron chelators all dampened the ability of LCN2 to enhance in vitro angiogenesis.	Iron	35-39	lipocalin 2	Rattus norvegicus	78-82
26286937-3	2015	Frataxin chaperones iron in the mitochondrial matrix and regulates the iron-sulfur cluster (ISC) assembly complex.	Iron	20-24	frataxin	Homo sapiens	0-8
25698971-6	2015	The results show that A1M is proteolytically cleaved, with formation of t-A1M, after exposure to MPO, and that t-A1M contains iron and heme-degradation products.	Iron	126-130	alpha-1-microglobulin/bikunin precursor	Homo sapiens	22-25
25486930-3	2015	We show that, besides increasing serum transferrin saturation without iron overload, hypotransferrinemia, when associated to mutations in HFE or HAMP or to acquired factors, can lead to clinically relevant iron burden.	Iron	206-210	homeostatic iron regulator	Homo sapiens	138-141
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	35-39	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	112-119
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	41-43	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	112-119
25162584-0	2014	SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells.	Iron	64-68	C-X-C motif chemokine ligand 12	Gallus gallus	0-5
26286937-3	2015	Frataxin chaperones iron in the mitochondrial matrix and regulates the iron-sulfur cluster (ISC) assembly complex.	Iron	71-75	frataxin	Homo sapiens	0-8
25187733-10	2014	Nocturnal pruritus was severe in nondiabetic patients (beta=1.7, t=3.8, P=0.0005) and weakened by the total iron binding capacity (beta=-2.9, t=-3.1, P=0.004).	Iron	108-112	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-138
25069567-9	2015	Finally, cranberry procyanidins forestalled the effect of iron/ascorbate on the protein expression of mitochondrial transcription factors (mtTFA, mtTFB1, mtTFB2).	Iron	58-62	transcription factor B1, mitochondrial	Homo sapiens	146-152
25069567-9	2015	Finally, cranberry procyanidins forestalled the effect of iron/ascorbate on the protein expression of mitochondrial transcription factors (mtTFA, mtTFB1, mtTFB2).	Iron	58-62	transcription factor B2, mitochondrial	Homo sapiens	154-160
26286937-5	2015	Decreased expression of frataxin is associated with decreased ISC assembly, mitochondrial iron accumulation, and increased oxidative stress, all of which contribute to mitochondrial dysfunction.	Iron	90-94	frataxin	Homo sapiens	24-32
26232328-1	2015	The transferrin receptor 1 (TfR1) is involved in cellular iron uptake and regulation of cell proliferation.	Iron	58-62	transferrin receptor	Homo sapiens	4-26
25454304-3	2015	Genetic testing for the HFE mutation can be performed in patients with elevated iron indices and a suspicion for hemochromatosis or liver disease.	Iron	80-84	homeostatic iron regulator	Homo sapiens	24-27
25144566-11	2014	Consistent risk estimates across population subgroups and persistence of the ACO1 rs2026739 association after adjustment for multiple testing suggest that genetic variation in iron-regulation and transport modulates susceptibility to DNP.	Iron	176-180	aconitase 1	Homo sapiens	77-81
26232328-1	2015	The transferrin receptor 1 (TfR1) is involved in cellular iron uptake and regulation of cell proliferation.	Iron	58-62	transferrin receptor	Homo sapiens	28-32
25597503-1	2015	Friedreich"s ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis.	Iron	159-163	frataxin	Homo sapiens	96-104
25117470-7	2014	We propose a regulatory role of Sat4p in the late steps of the maturation of a specific subset of mitochondrial iron-sulfur cluster proteins, including Aco1p and lipoate synthase Lip5p.	Iron	112-116	putative lipoate synthase	Saccharomyces cerevisiae S288C	179-184
26232328-3	2015	We have developed a mouse/human chimeric IgG3 specific for human TfR1 (ch128.1), which shows anti-tumor activity against certain malignant B cells in vitro through TfR1 degradation and iron deprivation, and in vivo through a mechanism yet to be defined.	Iron	185-189	Immunoglobulin heavy constant gamma 3	Mus musculus	41-45
25597503-2	2015	In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the formation of a persulfide intermediate on NFS1.	Iron	33-37	NFS1 cysteine desulfurase	Homo sapiens	76-80
25597503-2	2015	In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the formation of a persulfide intermediate on NFS1.	Iron	33-37	NFS1 cysteine desulfurase	Homo sapiens	150-154
26232328-3	2015	We have developed a mouse/human chimeric IgG3 specific for human TfR1 (ch128.1), which shows anti-tumor activity against certain malignant B cells in vitro through TfR1 degradation and iron deprivation, and in vivo through a mechanism yet to be defined.	Iron	185-189	transferrin receptor	Homo sapiens	65-69
26253232-6	2015	Mutants harboring defects in the RING DOMAIN LIGASE1 (RGLG1)(1) and RING DOMAIN LIGASE2 (RGLG2) showed a pleiotropic phenotype that resembled iron-deficient plants with reduced trichome density and the formation of branched root hairs.	Iron	142-146	RING domain ligase2	Arabidopsis thaliana	89-94
25236856-9	2015	Our data support the hypothesis that RAP-011 has unique biologic effects which prevent or circumvent depletion of mouse splenic iron stores.	Iron	128-132	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	37-40
24971490-0	2014	Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry.	Iron	25-29	frataxin	Homo sapiens	6-14
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	18-22	NFS1 cysteine desulfurase	Homo sapiens	84-88
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	18-22	frataxin	Homo sapiens	163-171
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	18-22	frataxin	Homo sapiens	173-176
26253232-7	2015	Proteomic and transcriptomic profiling of rglg1 rglg2 double mutants revealed that the functional RGLG protein is required for the regulation of a large set of iron-responsive proteins including the coordinated expression of ribosomal proteins.	Iron	160-164	RING domain ligase2	Arabidopsis thaliana	48-53
25727755-0	2015	Iron Regulatory Protein 1 Suppresses Hypoxia-Induced Iron Uptake Proteins Expression and Decreases Iron Levels in HepG2 Cells.	Iron	53-57	aconitase 1	Homo sapiens	0-25
24781685-1	2014	OBJECTIVES: Reticulocyte hemoglobin (Ret-Hb) content and soluble transferrin receptor (sTfR) are described as promising biomarkers in the analysis of iron status.	Iron	150-154	transferrin receptor	Homo sapiens	65-85
25634189-0	2015	Genetic variant coding for iron regulatory protein HFE contributes to hypertension, the TAMRISK study.	Iron	27-31	homeostatic iron regulator	Homo sapiens	51-54
25634189-2	2015	Major histocompatibility complex class I-like transmembrane protein (HFE) is involved in body iron metabolism.	Iron	94-98	homeostatic iron regulator	Homo sapiens	69-72
25727755-1	2015	Transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1) are important proteins for cellular iron uptake, and both are regulated transcriptionally through the binding of hypoxia-inducible factor 1 (HIF-1) to hypoxia-responsive elements (HREs) under hypoxic conditions.	Iron	104-108	transferrin receptor	Homo sapiens	0-20
25359467-3	2015	Lipocalin-2 (Lcn2), which is also known as neutrophil gelatinase-associated lipocalin, has multiple functions that include the regulation of cell death/survival, cell migration/invasion, cell differentiation and iron delivery.	Iron	212-216	lipocalin 2	Mus musculus	0-11
25034024-2	2014	While physiologically complex, FRDA is caused by deficits in production and expression of frataxin (FXN), a mitochondrial protein important for regulation of iron-sulfur cluster containing enzymes in the cell.	Iron	158-162	frataxin	Homo sapiens	31-35
25359467-3	2015	Lipocalin-2 (Lcn2), which is also known as neutrophil gelatinase-associated lipocalin, has multiple functions that include the regulation of cell death/survival, cell migration/invasion, cell differentiation and iron delivery.	Iron	212-216	lipocalin 2	Mus musculus	13-17
25727755-1	2015	Transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1) are important proteins for cellular iron uptake, and both are regulated transcriptionally through the binding of hypoxia-inducible factor 1 (HIF-1) to hypoxia-responsive elements (HREs) under hypoxic conditions.	Iron	104-108	transferrin receptor	Homo sapiens	22-26
25359467-3	2015	Lipocalin-2 (Lcn2), which is also known as neutrophil gelatinase-associated lipocalin, has multiple functions that include the regulation of cell death/survival, cell migration/invasion, cell differentiation and iron delivery.	Iron	212-216	lipocalin 2	Mus musculus	43-85
25034024-2	2014	While physiologically complex, FRDA is caused by deficits in production and expression of frataxin (FXN), a mitochondrial protein important for regulation of iron-sulfur cluster containing enzymes in the cell.	Iron	158-162	frataxin	Homo sapiens	90-98
25034024-2	2014	While physiologically complex, FRDA is caused by deficits in production and expression of frataxin (FXN), a mitochondrial protein important for regulation of iron-sulfur cluster containing enzymes in the cell.	Iron	158-162	frataxin	Homo sapiens	100-103
25034024-3	2014	Depletion of FXN is associated with dysfunction of ATP synthesis, mitochondrial iron accumulation, potentially an increase in oxidative stress, and cellular dysfunction.	Iron	80-84	frataxin	Homo sapiens	13-16
25727755-2	2015	These proteins are also regulated post-transcriptionally through the binding of iron regulatory protein 1 (IRP1) to iron-responsive elements (IREs) located in the mRNA untranslated region (UTR) to control cellular iron homeostasis.	Iron	80-84	aconitase 1	Homo sapiens	107-111
24915901-0	2014	Structural, spectroscopic and functional investigation into Fe-substituted MnSOD from human pathogen Clostridium difficile.	Iron	60-62	superoxide dismutase 2	Homo sapiens	75-80
25113747-6	2014	Dyclonine also rescued FXN-dependent enzyme deficiencies in the iron-sulfur enzymes, aconitase and succinate dehydrogenase.	Iron	64-68	frataxin	Homo sapiens	23-26
25727755-2	2015	These proteins are also regulated post-transcriptionally through the binding of iron regulatory protein 1 (IRP1) to iron-responsive elements (IREs) located in the mRNA untranslated region (UTR) to control cellular iron homeostasis.	Iron	116-120	aconitase 1	Homo sapiens	80-105
25727755-2	2015	These proteins are also regulated post-transcriptionally through the binding of iron regulatory protein 1 (IRP1) to iron-responsive elements (IREs) located in the mRNA untranslated region (UTR) to control cellular iron homeostasis.	Iron	116-120	aconitase 1	Homo sapiens	107-111
25727755-3	2015	In iron-deficient cells, IRP1-IRE interactions stabilize TfR1 and DMT1 mRNAs, enhancing iron uptake.	Iron	3-7	aconitase 1	Homo sapiens	25-29
25727755-3	2015	In iron-deficient cells, IRP1-IRE interactions stabilize TfR1 and DMT1 mRNAs, enhancing iron uptake.	Iron	3-7	transferrin receptor	Homo sapiens	57-61
24889527-5	2014	The corresponding gene (MED16) was isolated, and its biological functions in iron homeostasis were characterized using approaches such as gene expression, protein subcellular localization, protein-protein interaction and chromatin immunoprecipitation assay.	Iron	77-81	sensitive to freezing 6	Arabidopsis thaliana	24-29
25337805-0	2014	Electrochemistry and structure of the cobalt-free Li1+xMO2 (M = Li, Ni, Mn, Fe) composite cathode.	Iron	76-78	transglutaminase 1	Homo sapiens	50-58
25727755-3	2015	In iron-deficient cells, IRP1-IRE interactions stabilize TfR1 and DMT1 mRNAs, enhancing iron uptake.	Iron	88-92	aconitase 1	Homo sapiens	25-29
25337805-1	2014	The development of cathode materials with high capacity and cycle stability is essential to emerging electric-vehicle technologies, however, of serious environmental concern is that materials with these properties developed so far contain the toxic and expensive Co. We report here the Li-rich, Co-free Li1+xMO2 (M = Li, Ni, Mn, Fe) composite cathode material, prepared via a template-free, one-step wet-chemical method followed by conventional annealing in an oxygen atmosphere.	Iron	329-331	transglutaminase 1	Homo sapiens	303-311
24889527-7	2014	The MED16 mutants showed a low shoot iron concentration and severe leaf chlorosis under iron limitation, whereas it grew normally as wild-type under iron sufficiency.	Iron	37-41	sensitive to freezing 6	Arabidopsis thaliana	4-9
24889527-7	2014	The MED16 mutants showed a low shoot iron concentration and severe leaf chlorosis under iron limitation, whereas it grew normally as wild-type under iron sufficiency.	Iron	88-92	sensitive to freezing 6	Arabidopsis thaliana	4-9
25727755-3	2015	In iron-deficient cells, IRP1-IRE interactions stabilize TfR1 and DMT1 mRNAs, enhancing iron uptake.	Iron	88-92	transferrin receptor	Homo sapiens	57-61
24889527-7	2014	The MED16 mutants showed a low shoot iron concentration and severe leaf chlorosis under iron limitation, whereas it grew normally as wild-type under iron sufficiency.	Iron	88-92	sensitive to freezing 6	Arabidopsis thaliana	4-9
25727755-4	2015	However, little is known about the impact of IRP1 on the regulation of cellular iron homeostasis under hypoxia.	Iron	80-84	aconitase 1	Homo sapiens	45-49
25727755-7	2015	Under hypoxic conditions, ferrous iron uptake, the labile iron pool (LIP), and total intracellular iron reduced when IRP1 was overexpressed and further increased when IRP1 was knocked down.	Iron	34-38	aconitase 1	Homo sapiens	117-121
25727755-7	2015	Under hypoxic conditions, ferrous iron uptake, the labile iron pool (LIP), and total intracellular iron reduced when IRP1 was overexpressed and further increased when IRP1 was knocked down.	Iron	58-62	aconitase 1	Homo sapiens	117-121
25280951-0	2014	In vitro heme and non-heme iron capture from hemoglobin, myoglobin and ferritin by bovine lactoferrin and implications for suppression of reactive oxygen species in vivo.	Iron	27-31	myoglobin	Bos taurus	57-66
25727755-7	2015	Under hypoxic conditions, ferrous iron uptake, the labile iron pool (LIP), and total intracellular iron reduced when IRP1 was overexpressed and further increased when IRP1 was knocked down.	Iron	58-62	aconitase 1	Homo sapiens	117-121
25280951-5	2014	The transfer of heme iron from either intact or digested forms of hemoglobin and myoglobin and from intact ferritin was demonstrated by in vitro methods, monitoring Fe-saturation status of Lf by changes in absorptivity at 465 nm.	Iron	21-25	myoglobin	Bos taurus	81-90
24798971-3	2014	The aim of this study was to determine whether iron biomarkers and HFE genotypes, which influence iron regulation, constitute risk factors for PC.	Iron	98-102	homeostatic iron regulator	Homo sapiens	67-70
25727755-9	2015	In summary, IRP1 suppressed TfR1/DMT1 (+IRE) expression, limited the cellular iron content and decreased lactate dehydrogenase (LDH) release induced by hypoxia.	Iron	78-82	aconitase 1	Homo sapiens	12-16
26375377-6	2015	The disease pathogenesis is fundamentally due to a lack of frataxin, which is claimed to play a role in iron-sulfur cluster synthesis.	Iron	104-108	frataxin	Homo sapiens	59-67
25117307-9	2014	IRP2 can regulate the expression of TfR and Fn by changing its own protein expression and thereby regulate iron metabolism.	Iron	107-111	transferrin receptor	Homo sapiens	36-39
25447561-5	2014	Two genes related to iron metabolism, transferrin receptor 1 (TfR1) and H ferritin (HFt), were quantified by RT-PCR.	Iron	21-25	transferrin receptor	Mus musculus	38-60
25447561-5	2014	Two genes related to iron metabolism, transferrin receptor 1 (TfR1) and H ferritin (HFt), were quantified by RT-PCR.	Iron	21-25	transferrin receptor	Mus musculus	62-66
26140619-3	2015	The advantage of using Fe(SCN)3 as iron source is that the obtained catalyst has a high level of S doping and high surface area, and thus exhibits excellent ORR activity (23 A g(-1) at 0.80 V) in 0.1 M H2SO4 solution.	Iron	35-39	HCLS1 associated protein X-1	Homo sapiens	26-31
25216685-0	2014	Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels.	Iron	0-4	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-134
25216685-0	2014	Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels.	Iron	0-4	transient receptor potential cation channel subfamily V member 1	Homo sapiens	136-141
25216685-6	2014	Taken together, these data show that transient receptor potential vanilloid type 1 activation/desensitization influences tartrate-resistant acid phosphatase expression and activity, and this effect is dependent on iron, suggesting a pivotal role for iron overload in the dysregulation of bone metabolism in patients with thalassemia major.	Iron	214-218	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-82
25216685-6	2014	Taken together, these data show that transient receptor potential vanilloid type 1 activation/desensitization influences tartrate-resistant acid phosphatase expression and activity, and this effect is dependent on iron, suggesting a pivotal role for iron overload in the dysregulation of bone metabolism in patients with thalassemia major.	Iron	250-254	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-82
25385842-0	2014	Hyperinsulinemia induces hepatic iron overload by increasing liver TFR1 via the PI3K/IRP2 pathway.	Iron	33-37	transferrin receptor	Rattus norvegicus	67-71
25385842-9	2014	In conclusion, the findings of this study indicate that hyperinsulnemia could induce hepatic iron overload by upregulating liver TFR1 via the PI3K/AKT/mTOR/IRP2 pathway, which may be one of the main reasons for the occurrence of DIOS.	Iron	93-97	transferrin receptor	Rattus norvegicus	129-133
25044349-1	2014	IscU and IscS are two essential proteins in the machine responsible for the biogenesis of iron-sulfur clusters, prosthetic groups that are involved in several essential functions.	Iron	90-94	NFS1 cysteine desulfurase	Homo sapiens	9-13
24556216-5	2014	Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.	Iron	29-33	homeostatic iron regulator	Homo sapiens	244-247
25419056-11	2014	The Glutamate--cysteine ligase catalytic subunit (GCLC), the only protein annotated with the term sulfur amino acid metabolism process, had increased abundance while succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor (SDHB), a tumor suppressor, had decreased abundance.	Iron	203-207	glutamate-cysteine ligase catalytic subunit	Homo sapiens	50-54
26251447-5	2015	We found that transition metals copper (Cu) and iron (Fe) activate recombinant TFEB and stimulate the expression of TFEB-dependent genes in TFEB-overexpressing cells.	Iron	48-52	transcription factor EB	Homo sapiens	79-83
24733507-1	2014	The canonical transient receptor potential 6 (TRPC6) protein is a non-selective cation channel able to transport essential trace elements like iron (Fe) and zinc (Zn) through the plasma membrane.	Iron	143-147	transient receptor potential cation channel subfamily C member 6	Homo sapiens	46-51
24733507-1	2014	The canonical transient receptor potential 6 (TRPC6) protein is a non-selective cation channel able to transport essential trace elements like iron (Fe) and zinc (Zn) through the plasma membrane.	Iron	149-151	transient receptor potential cation channel subfamily C member 6	Homo sapiens	46-51
24724721-3	2014	Most genes involved in PS biosynthesis and secretion (HvNAS3, HvNAS4, HvNAS6, HvNAS7, HvNAAT-A, HvDMAS1 and HvTOM1) induced by Fe deprivation were also significantly upregulated in the presence of Cd under Fe sufficient conditions.	Iron	127-129	Deoxymugineic acid synthase 1	Hordeum vulgare	96-103
25155598-0	2014	Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IkappaB-alpha expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.	Iron	36-40	cyclin dependent kinase 2	Homo sapiens	95-99
26251447-5	2015	We found that transition metals copper (Cu) and iron (Fe) activate recombinant TFEB and stimulate the expression of TFEB-dependent genes in TFEB-overexpressing cells.	Iron	48-52	transcription factor EB	Homo sapiens	116-120
25155598-3	2014	We previously showed that chelation of intracellular iron inhibits CDK2 and CDK9 activities and suppresses HIV-1 transcription, but the mechanism of the inhibition was not understood.	Iron	53-57	cyclin dependent kinase 2	Homo sapiens	67-71
25155598-8	2014	The iron chelators inhibited CDK2 activity and reduced the amount of CDK9/cyclin T1 in the large P-TEFb complex.	Iron	4-8	cyclin dependent kinase 2	Homo sapiens	29-33
26251447-5	2015	We found that transition metals copper (Cu) and iron (Fe) activate recombinant TFEB and stimulate the expression of TFEB-dependent genes in TFEB-overexpressing cells.	Iron	48-52	transcription factor EB	Homo sapiens	116-120
25155598-9	2014	Iron chelators reduced HIV-1 Gag and Env mRNA synthesis but had no effect on HIV-1 reverse transcription.	Iron	0-4	Pr55(Gag)	Human immunodeficiency virus 1	29-32
24927598-0	2014	An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14.	Iron	3-7	solute carrier family 39 member 14	Homo sapiens	120-125
26251447-5	2015	We found that transition metals copper (Cu) and iron (Fe) activate recombinant TFEB and stimulate the expression of TFEB-dependent genes in TFEB-overexpressing cells.	Iron	54-56	transcription factor EB	Homo sapiens	79-83
24927598-4	2014	In an attempt to dissect the molecular mechanisms by which iron regulates ZIP14 levels, we found that ZIP14 is endocytosed, extracted from membranes, deglycosylated, and degraded by proteasomes.	Iron	59-63	solute carrier family 39 member 14	Homo sapiens	74-79
24927598-4	2014	In an attempt to dissect the molecular mechanisms by which iron regulates ZIP14 levels, we found that ZIP14 is endocytosed, extracted from membranes, deglycosylated, and degraded by proteasomes.	Iron	59-63	solute carrier family 39 member 14	Homo sapiens	102-107
25155598-9	2014	Iron chelators reduced HIV-1 Gag and Env mRNA synthesis but had no effect on HIV-1 reverse transcription.	Iron	0-4	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	37-40
24927598-6	2014	Iron inhibited membrane extraction of internalized ZIP14, resulting in higher steady-state levels of ZIP14.	Iron	0-4	solute carrier family 39 member 14	Homo sapiens	51-56
26251447-5	2015	We found that transition metals copper (Cu) and iron (Fe) activate recombinant TFEB and stimulate the expression of TFEB-dependent genes in TFEB-overexpressing cells.	Iron	54-56	transcription factor EB	Homo sapiens	116-120
24927598-6	2014	Iron inhibited membrane extraction of internalized ZIP14, resulting in higher steady-state levels of ZIP14.	Iron	0-4	solute carrier family 39 member 14	Homo sapiens	101-106
26251447-5	2015	We found that transition metals copper (Cu) and iron (Fe) activate recombinant TFEB and stimulate the expression of TFEB-dependent genes in TFEB-overexpressing cells.	Iron	54-56	transcription factor EB	Homo sapiens	116-120
25326704-1	2014	Members of the SLC11 (NRAMP) family transport iron and other transition-metal ions across cellular membranes.	Iron	46-50	solute carrier family 34 member 1	Homo sapiens	15-20
26116529-0	2015	RGS19 converts iron deprivation stress into a growth-inhibitory signal.	Iron	15-19	regulator of G protein signaling 19	Homo sapiens	0-5
25327288-0	2014	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.	Iron	101-105	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	10-15
25327288-6	2014	NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to autolysosomes following starvation or iron depletion.	Iron	65-69	nuclear receptor coactivator 4	Mus musculus	0-5
25327288-6	2014	NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to autolysosomes following starvation or iron depletion.	Iron	178-182	nuclear receptor coactivator 4	Mus musculus	0-5
25327288-7	2014	Interestingly, Ncoa4(-/-) mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells.	Iron	66-70	nuclear receptor coactivator 4	Mus musculus	15-20
25327288-7	2014	Interestingly, Ncoa4(-/-) mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells.	Iron	139-143	nuclear receptor coactivator 4	Mus musculus	15-20
25327288-8	2014	Taken together, the results of this study provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo.	Iron	187-191	nuclear receptor coactivator 4	Mus musculus	163-168
24798331-0	2014	Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.	Iron	103-107	Mmt1p	Saccharomyces cerevisiae S288C	54-58
24798331-0	2014	Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.	Iron	103-107	Mmt2p	Saccharomyces cerevisiae S288C	63-67
24798331-0	2014	Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.	Iron	148-152	Mmt1p	Saccharomyces cerevisiae S288C	54-58
24798331-0	2014	Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.	Iron	148-152	Mmt2p	Saccharomyces cerevisiae S288C	63-67
24798331-2	2014	Overexpression of MMT1/2 led to changes in cellular metal homeostasis (increased iron sensitivity, decreased cobalt sensitivity, increased sensitivity to copper), oxidant generation, and increased sensitivity to H2O2.	Iron	81-85	Mmt1p	Saccharomyces cerevisiae S288C	18-24
25352340-4	2014	SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis.	Iron	35-39	homeostatic iron regulator	Homo sapiens	51-54
26116529-3	2015	We investigated the role of RGS19, a regulator of G-protein signaling, in iron chelator-induced NDRG1 overexpression in HeLa cells.	Iron	74-78	regulator of G protein signaling 19	Homo sapiens	28-33
26149889-3	2015	Here we conjugated CRT peptide, an iron-mimicry moiety targeting the whole complex of Tf/TfR, to poly(ethylene glycol)-poly(l-lactic-co-glycolic acid) nanoparticles (CRT-NP), to open a new route to overcome such obstacle.	Iron	35-39	transferrin receptor	Mus musculus	89-92
25311416-2	2014	Astrocytes secrete a soluble form of ceruloplasmin (sCp) which, in turn, acts to export iron from ferroportin (Fpn) on the basolateral surface of BMVEC.	Iron	88-92	solute carrier family 50 member 1	Homo sapiens	52-55
25311416-9	2014	Furthermore, the hBMVEC-induced increase in neighboring C6 glioma sCp gene expression leads to an increased rate of hBMVEC iron efflux.	Iron	123-127	solute carrier family 50 member 1	Homo sapiens	66-69
25311416-10	2014	Taken together, our results indicate that hBMVEC-secreted cytokine activity increases the gene expression of neighboring C6 glioma sCp, which reciprocally acts on basolateral hBMVEC Fpn to enhance brain iron import.	Iron	203-207	solute carrier family 50 member 1	Homo sapiens	131-134
24778179-0	2014	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	Iron	18-22	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	0-5
24778179-0	2014	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	Iron	69-73	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	0-5
24778179-3	2014	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo, given that mice lacking FBXL5 die during early embryogenesis as a result of unrestrained IRP2 activity and oxidative stress attributable to excessive iron accumulation.	Iron	46-50	F-box and leucine-rich repeat protein 5	Mus musculus	4-9
24778179-3	2014	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo, given that mice lacking FBXL5 die during early embryogenesis as a result of unrestrained IRP2 activity and oxidative stress attributable to excessive iron accumulation.	Iron	221-225	F-box and leucine-rich repeat protein 5	Mus musculus	4-9
26510149-2	2015	The C282Y homozygotes and C282Y/H63D compound heterozygotes are the most likely human haemochromatosis protein (HFE) variants to cause iron over-load.	Iron	135-139	homeostatic iron regulator	Homo sapiens	112-115
24896847-0	2014	The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.	Iron	59-63	hephaestin	Mus musculus	28-38
24896847-1	2014	Hephaestin is a vertebrate multicopper ferroxidase important for the transfer of dietary iron from intestinal cells to the blood.	Iron	89-93	hephaestin	Mus musculus	0-10
24896847-9	2014	In addition, the similarities of the phenotypes of the whole body and intestine-specific hephaestin knockout mice clarify the important role of hephaestin specifically in intestinal enterocytes in maintaining whole body iron homeostasis.	Iron	220-224	hephaestin	Mus musculus	144-154
24896847-10	2014	These mouse models will serve as valuable tools to study the role of hephaestin and associated proteins in iron transport in the small intestine and other tissues.	Iron	107-111	hephaestin	Mus musculus	69-79
25111396-3	2014	With iron(ii) halides and tert-butyl groups on the phenoxy ligands L2 and L3, the iron(iii) complexes [(L2)FeX2] {where X = Cl (3), Br (4) and I = (5)} and [(L3)FeCl2] (6) were formed.	Iron	82-86	zinc activated ion channel	Homo sapiens	67-76
26032732-0	2015	Interaction of frataxin, an iron binding protein, with IscU of Fe-S clusters biogenesis pathway and its upregulation in AmpB resistant Leishmania donovani.	Iron	28-32	frataxin	Homo sapiens	15-23
25314357-2	2014	The Hemochromatosis and Iron Overload Screening (HEIRS) Study screened 101,168 North American participants for serum ferritin level and transferrin saturation, and C282Y genotyping for the HFE gene.	Iron	24-28	homeostatic iron regulator	Homo sapiens	189-192
24658816-3	2014	The TMPRSS6 gene, encoding the liver-expressed serine protease matriptase-2, is the main inhibitor of hepcidin and inactivation of TMPRSS6 leads to iron deficiency with high hepcidin levels.	Iron	148-152	transmembrane serine protease 6	Mus musculus	4-11
26032732-0	2015	Interaction of frataxin, an iron binding protein, with IscU of Fe-S clusters biogenesis pathway and its upregulation in AmpB resistant Leishmania donovani.	Iron	63-67	frataxin	Homo sapiens	15-23
24658816-3	2014	The TMPRSS6 gene, encoding the liver-expressed serine protease matriptase-2, is the main inhibitor of hepcidin and inactivation of TMPRSS6 leads to iron deficiency with high hepcidin levels.	Iron	148-152	transmembrane serine protease 6	Mus musculus	63-75
26032732-8	2015	Furthermore, we observed that the cysteine desulphurase activity of the purified Ld-IscS protein was stimulated in the presence of Ld-frataxin and Ld-IscU, particularly in the presence of iron; neither Ld-frataxin nor Ld-IscU alone had significant effects on Ld-IscS activity.	Iron	188-192	NFS1 cysteine desulfurase	Homo sapiens	84-88
24658816-3	2014	The TMPRSS6 gene, encoding the liver-expressed serine protease matriptase-2, is the main inhibitor of hepcidin and inactivation of TMPRSS6 leads to iron deficiency with high hepcidin levels.	Iron	148-152	transmembrane serine protease 6	Mus musculus	131-138
24971814-5	2014	Docking of aforementioned compounds to CYP17A1 revealed that steroid fragments of compound 1 and abiraterone 3 occupied close positions; oxazoline cycle of compound 1 was coordinated with heme iron similarly to pyridine cycle of abiraterone 3.	Iron	193-197	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	39-46
25988595-8	2015	Increased expression of DcytB and DMT1 genes in the duodenum resulting in increased iron availability was defined as the mechanism for these effects.	Iron	84-88	cytochrome b reductase 1	Rattus norvegicus	24-29
25075125-6	2014	Iron injection increased hepatic hepcidin mRNA levels in mice deficient in either BMPR2 or ActR2a, but not in mice deficient in both BMP type II receptors.	Iron	0-4	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	82-87
25075125-8	2014	These results suggest that BMP type II receptors, BMPR2 and ActR2a, have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.	Iron	147-151	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	50-55
24277523-12	2014	NOX2 inhibitor diphenylene iodonium protects against iron-elicited dopaminergic neurotoxicity through decreasing microglial O2 - generation, and NOX2-/- mice are resistant to the neurotoxicity by reducing microglial O2 - production, indicating that iron-elicited dopaminergic neurotoxicity is dependent of NOX2, a O2 --generating enzyme.	Iron	53-57	cytochrome b-245, beta polypeptide	Mus musculus	0-4
24390816-1	2014	BACKGROUND: Friedreich ataxia (FRDA) generally results from reduced frataxin, a mitochondrial protein involved in iron metabolism.	Iron	114-118	frataxin	Homo sapiens	12-29
24390816-1	2014	BACKGROUND: Friedreich ataxia (FRDA) generally results from reduced frataxin, a mitochondrial protein involved in iron metabolism.	Iron	114-118	frataxin	Homo sapiens	68-76
26192321-1	2015	In Drosophila melanogaster, iron is stored in the cellular endomembrane system inside a protein cage formed by 24 ferritin subunits of two types (Fer1HCH and Fer2LCH) in a 1:1 stoichiometry.	Iron	28-32	Ferritin 1 heavy chain homologue	Drosophila melanogaster	114-122
24728987-0	2014	Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions.	Iron	18-22	aconitase 1	Homo sapiens	52-77
24728987-8	2014	IRP1/IRE-RNA complex has a much shorter life-time than the eIF4F/IRE-RNA complex, which suggests that both rate of assembly and stability of the complexes are important, and that allows this regulatory system to respond rapidly to change in cellular iron.	Iron	250-254	aconitase 1	Homo sapiens	0-4
25197096-0	2014	Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana.	Iron	34-38	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi	Arabidopsis thaliana	66-72
25046762-8	2014	Expression of this transgene AtHMA4 also resulted in distinct changes in Fe accumulation in Zn-exposed plants, and Fe/Zn-accumulation in Cd-exposed plants, even though Fe is not a substrate for AtHMA4.	Iron	73-75	heavy metal atpase 4	Arabidopsis thaliana	29-35
26192321-1	2015	In Drosophila melanogaster, iron is stored in the cellular endomembrane system inside a protein cage formed by 24 ferritin subunits of two types (Fer1HCH and Fer2LCH) in a 1:1 stoichiometry.	Iron	28-32	Ferritin 1 heavy chain homologue	Drosophila melanogaster	146-153
25046762-8	2014	Expression of this transgene AtHMA4 also resulted in distinct changes in Fe accumulation in Zn-exposed plants, and Fe/Zn-accumulation in Cd-exposed plants, even though Fe is not a substrate for AtHMA4.	Iron	115-117	heavy metal atpase 4	Arabidopsis thaliana	29-35
25046762-8	2014	Expression of this transgene AtHMA4 also resulted in distinct changes in Fe accumulation in Zn-exposed plants, and Fe/Zn-accumulation in Cd-exposed plants, even though Fe is not a substrate for AtHMA4.	Iron	115-117	heavy metal atpase 4	Arabidopsis thaliana	29-35
26192321-7	2015	Furthermore, we show that ferritin maternal contribution, which varies reflecting the mother"s iron stores, is used in early development.	Iron	95-99	Ferritin 1 heavy chain homologue	Drosophila melanogaster	26-34
25046762-10	2014	The reduction of Fe accumulation observed in AtHMA4-transformants was accompanied by up-regulation of Fe-deficiency marker genes (LeFER, LeFRO1, LeIRT1), whereas down-regulation was detected in plants with the status of Fe-sufficiency.	Iron	17-19	heavy metal atpase 4	Arabidopsis thaliana	45-51
25046762-10	2014	The reduction of Fe accumulation observed in AtHMA4-transformants was accompanied by up-regulation of Fe-deficiency marker genes (LeFER, LeFRO1, LeIRT1), whereas down-regulation was detected in plants with the status of Fe-sufficiency.	Iron	17-19	ferric-chelate reductase	Solanum lycopersicum	137-143
24549883-3	2014	Here, we examined whether four of the subgroup Ib basic helix-loop-helix transcription factors (bHLH38, bHLH39, bHLH100, bHLH101), previously implicated in iron homeostasis in roots, also play a role in regulating iron metabolism in developing leaves.	Iron	156-160	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	121-128
26192321-9	2015	Overall, our results are consistent with insect ferritin combining three functions: iron storage, intercellular iron transport, and protection from iron-induced oxidative stress.	Iron	84-88	Ferritin 1 heavy chain homologue	Drosophila melanogaster	48-56
24549883-8	2014	When grown in agar plates with reduced iron concentration, triple bhlh39 bhlh100 bhlh101 mutant plants were smaller than wild-type plants.	Iron	39-43	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	81-88
25046762-12	2014	Thus, the modifications of Zn/Fe/Cd translocation to aerial plant parts due to AtHMA4 expression are closely related to the alteration of the endogenous Zn-Fe-Cd cross-homeostasis network of tomato.	Iron	30-32	heavy metal atpase 4	Arabidopsis thaliana	79-85
26192321-9	2015	Overall, our results are consistent with insect ferritin combining three functions: iron storage, intercellular iron transport, and protection from iron-induced oxidative stress.	Iron	112-116	Ferritin 1 heavy chain homologue	Drosophila melanogaster	48-56
26192321-9	2015	Overall, our results are consistent with insect ferritin combining three functions: iron storage, intercellular iron transport, and protection from iron-induced oxidative stress.	Iron	112-116	Ferritin 1 heavy chain homologue	Drosophila melanogaster	48-56
25782996-1	2015	BACKGROUND: Neutrophil-derived lipocalin-2 exerts bacteriostatic effects through retardation of iron uptake by the Gram-negative organisms like Escherichia coli.	Iron	96-100	lipocalin 2	Rattus norvegicus	31-42
24111776-5	2014	Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.	Iron	53-55	microRNA 210	Homo sapiens	8-15
24111776-5	2014	Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.	Iron	53-55	microRNA 210	Homo sapiens	207-214
24111776-5	2014	Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.	Iron	53-55	microRNA 210	Homo sapiens	207-214
26588513-1	2014	The bond dissociation energy of a series of metallocenium ions, i.e., the energy difference of the reaction MCp2(+)   MCp(+) + Cp  (with M = Ti, V, Cr, Mn, Fe, Co, and Ni), was studied by means of multiconfigurational perturbation theory (CASPT2, RASPT2, NEVPT2) and restricted coupled cluster theory (CCSD(T)).	Iron	156-158	C-C motif chemokine ligand 8	Homo sapiens	108-112
24714526-4	2014	During chronic iron/heme deficiency in vivo, this HRI-eIF2alphaP-ATF4 signaling is necessary both to reduce oxidative stress and to promote erythroid differentiation.	Iron	15-19	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	50-53
24714526-4	2014	During chronic iron/heme deficiency in vivo, this HRI-eIF2alphaP-ATF4 signaling is necessary both to reduce oxidative stress and to promote erythroid differentiation.	Iron	15-19	eukaryotic translation initiation factor 2 subunit alpha	Homo sapiens	54-58
26070639-14	2015	CONCLUSIONS: The results indicate that SlbHLH068, as a putative transcription factor, is involved in iron homeostasis in tomato via an interaction with FER.	Iron	101-105	bHLH transcriptional regulator	Solanum lycopersicum	152-155
24470066-6	2014	This analysis, together with our genetic, microscopic, and biochemical evidence, showed that embryonic phagocytes express protein machinery that is essential for the recycling of cellular iron and that this expression can be regulated by TLR engagement in a MyD88-dependent manner, leading to typical inflammatory M1 responses.	Iron	188-192	MYD88 innate immune signal transduction adaptor	Homo sapiens	258-263
25981872-1	2015	Human hemochromatosis protein (HFE), a major histocompatibility complex class I-like integral membrane protein, participates in the down regulation of intestinal iron absorption by binding to transferrin receptor (TR).	Iron	162-166	homeostatic iron regulator	Homo sapiens	31-34
24486949-9	2014	RESULTS: Flvcr1a(fl/fl);alb-cre mice accumulated heme and iron in liver despite up-regulation of heme oxygenase 1, ferroportin, and ferritins.	Iron	58-62	albumin	Mus musculus	24-27
25518660-1	2014	This research described the heterogeneous reactions of persulfate with different particle sizes of zero-valent iron (including 1 mm-ZVI,150 mum-ZVI,50 nm-ZVI) for degradation of acid orange 7(AO7) , and studied the kinetics and intermediate products of AO7 under these systems.	Iron	111-115	ring finger protein 25	Homo sapiens	192-195
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	51-54	ring finger protein 25	Homo sapiens	102-105
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	51-54	ring finger protein 25	Homo sapiens	139-142
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	209-212	ring finger protein 25	Homo sapiens	102-105
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	209-212	ring finger protein 25	Homo sapiens	139-142
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	209-212	ring finger protein 25	Homo sapiens	102-105
24569067-8	2014	The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin.	Iron	169-173	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	19-88
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	209-212	ring finger protein 25	Homo sapiens	139-142
25981872-1	2015	Human hemochromatosis protein (HFE), a major histocompatibility complex class I-like integral membrane protein, participates in the down regulation of intestinal iron absorption by binding to transferrin receptor (TR).	Iron	162-166	transferrin receptor	Homo sapiens	192-212
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	209-212	ring finger protein 25	Homo sapiens	102-105
25518660-2	2014	The results demonstrated that these three types of ZVI were efficient in promoting the degradation of AO7, the degradation efficiencies of AO7 were 43% , 97% , and 100% within 90 min respectively, in the 1 mm-ZVI,150 mum-ZVI and 50 nm- ZVI systems, respectively.	Iron	209-212	ring finger protein 25	Homo sapiens	139-142
25518660-4	2014	And the different ZVI types exhibited difference on the AO7 degradation rate constant, which ranged as 50 nm-ZVI &gt; 150 mum-ZVI &gt; 1 mm-ZVI.	Iron	18-21	ring finger protein 25	Homo sapiens	56-59
24569067-8	2014	The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin.	Iron	169-173	transferrin receptor	Mus musculus	90-112
24569067-8	2014	The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin.	Iron	169-173	transferrin receptor	Mus musculus	114-118
25518660-4	2014	And the different ZVI types exhibited difference on the AO7 degradation rate constant, which ranged as 50 nm-ZVI &gt; 150 mum-ZVI &gt; 1 mm-ZVI.	Iron	109-112	ring finger protein 25	Homo sapiens	56-59
25981872-1	2015	Human hemochromatosis protein (HFE), a major histocompatibility complex class I-like integral membrane protein, participates in the down regulation of intestinal iron absorption by binding to transferrin receptor (TR).	Iron	162-166	transferrin receptor	Homo sapiens	214-216
25518660-4	2014	And the different ZVI types exhibited difference on the AO7 degradation rate constant, which ranged as 50 nm-ZVI &gt; 150 mum-ZVI &gt; 1 mm-ZVI.	Iron	109-112	ring finger protein 25	Homo sapiens	56-59
25518660-4	2014	And the different ZVI types exhibited difference on the AO7 degradation rate constant, which ranged as 50 nm-ZVI &gt; 150 mum-ZVI &gt; 1 mm-ZVI.	Iron	109-112	ring finger protein 25	Homo sapiens	56-59
24599681-0	2014	Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liver.	Iron	126-130	glucose-6-phosphate dehydrogenase	Rattus norvegicus	14-47
25981872-2	2015	HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells.	Iron	36-40	homeostatic iron regulator	Homo sapiens	0-3
24980968-9	2014	Iron chelation by excess Ent or Ybt significantly increased Lcn2-induced secretion of IL-8, IL-6, and CCL20.	Iron	0-4	C-C motif chemokine ligand 20	Homo sapiens	102-107
25981872-2	2015	HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells.	Iron	36-40	transferrin receptor	Homo sapiens	49-51
25981872-2	2015	HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells.	Iron	79-83	homeostatic iron regulator	Homo sapiens	0-3
24867923-0	2014	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis.	Iron	26-30	oligopeptide transporter	Arabidopsis thaliana	0-4
25981872-2	2015	HFE competes with transferrin-bound iron for the TR and thus reduces uptake of iron into cells.	Iron	79-83	transferrin receptor	Homo sapiens	49-51
24867923-0	2014	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis.	Iron	74-78	oligopeptide transporter	Arabidopsis thaliana	0-4
25981872-3	2015	On the other hand, a lack of HFE increases the intestinal absorption of iron similarly to iron deficiency associated with increasing in absorption and deposition of lead.	Iron	72-76	homeostatic iron regulator	Homo sapiens	29-32
24867923-4	2014	Studies in Arabidopsis thaliana show that OPT3 loads iron into the phloem, facilitates iron recirculation from the xylem to the phloem, and regulates both shoot-to-root iron signaling and iron redistribution from mature to developing tissues.	Iron	53-57	oligopeptide transporter	Arabidopsis thaliana	42-46
24867923-4	2014	Studies in Arabidopsis thaliana show that OPT3 loads iron into the phloem, facilitates iron recirculation from the xylem to the phloem, and regulates both shoot-to-root iron signaling and iron redistribution from mature to developing tissues.	Iron	87-91	oligopeptide transporter	Arabidopsis thaliana	42-46
25085015-1	2014	Hereditary hemochromatosis (HFE) variants correlating with body iron levels have shown associations with cancer risk, including childhood acute lymphoblastic leukemia (ALL).	Iron	64-68	homeostatic iron regulator	Homo sapiens	28-31
25085015-7	2014	Our results replicated previous HFE risk associations with childhood ALL in a US population and demonstrated novel associations for IRG SNPs, thereby strengthening the hypothesis that iron excess mediated by genetic variants contributes to childhood ALL risk.	Iron	184-188	homeostatic iron regulator	Homo sapiens	32-35
24867923-4	2014	Studies in Arabidopsis thaliana show that OPT3 loads iron into the phloem, facilitates iron recirculation from the xylem to the phloem, and regulates both shoot-to-root iron signaling and iron redistribution from mature to developing tissues.	Iron	87-91	oligopeptide transporter	Arabidopsis thaliana	42-46
24867923-4	2014	Studies in Arabidopsis thaliana show that OPT3 loads iron into the phloem, facilitates iron recirculation from the xylem to the phloem, and regulates both shoot-to-root iron signaling and iron redistribution from mature to developing tissues.	Iron	87-91	oligopeptide transporter	Arabidopsis thaliana	42-46
25723140-9	2015	In subsample mothers, maternal ARVs were associated with tissue iron depletion (TfR &gt;8.3 mg/L) (risk ratio: 3.1, P &lt; 0.01), but not in ARV-treated mothers receiving LNS (P = 0.17).	Iron	64-68	transferrin receptor	Homo sapiens	80-83
24867923-5	2014	We also uncovered an aspect of crosstalk between iron homeostasis and cadmium partitioning that is mediated by OPT3.	Iron	49-53	oligopeptide transporter	Arabidopsis thaliana	111-115
24792433-2	2014	It has been linked to expansion of a GAA-triplet repeat in the first intron of the FXN gene, leading to a reduced level of frataxin, a mitochondrial protein which, by controlling both iron entry and/or sulfide production, is essential to properly assemble and protect the Fe-S cluster during the initial stage of biogenesis.	Iron	184-188	frataxin	Homo sapiens	83-86
24792433-2	2014	It has been linked to expansion of a GAA-triplet repeat in the first intron of the FXN gene, leading to a reduced level of frataxin, a mitochondrial protein which, by controlling both iron entry and/or sulfide production, is essential to properly assemble and protect the Fe-S cluster during the initial stage of biogenesis.	Iron	184-188	frataxin	Homo sapiens	123-131
24904118-2	2014	HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages.	Iron	102-106	homeostatic iron regulator	Homo sapiens	0-3
24904118-2	2014	HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages.	Iron	140-144	homeostatic iron regulator	Homo sapiens	0-3
24792433-2	2014	It has been linked to expansion of a GAA-triplet repeat in the first intron of the FXN gene, leading to a reduced level of frataxin, a mitochondrial protein which, by controlling both iron entry and/or sulfide production, is essential to properly assemble and protect the Fe-S cluster during the initial stage of biogenesis.	Iron	272-274	frataxin	Homo sapiens	83-86
25891893-3	2015	Transferrin receptor 1 (TfR1) controls the rate of cellular iron uptake by tuning the amount of iron delivered to the cells to meet metabolic needs.	Iron	60-64	transferrin receptor	Homo sapiens	0-22
24792433-2	2014	It has been linked to expansion of a GAA-triplet repeat in the first intron of the FXN gene, leading to a reduced level of frataxin, a mitochondrial protein which, by controlling both iron entry and/or sulfide production, is essential to properly assemble and protect the Fe-S cluster during the initial stage of biogenesis.	Iron	272-274	frataxin	Homo sapiens	123-131
25098749-15	2014	Moreover, the zinc and iron bound forms of TTP are equally adept at discriminating between RNA targets, which we have demonstrated via a fluorescence anisotropy based approach.	Iron	23-27	ZFP36 ring finger protein	Homo sapiens	43-46
26373158-1	2015	Iron-based MIL-53 crystals with uniform size were successfully synthesized using a microwave-assisted solvothermal method and characterized by XRD, FE-SEM and DRS.	Iron	0-4	sushi repeat containing protein X-linked	Homo sapiens	148-162
25084497-9	2014	The iron(III) compounds (6 and 7), on the other hand, show at least four irreversible processes, appearing at Epc = -0.20, -1.0, -1.58, and -1.68 V in compound 6 (processes IV-VII), together with a reversible process (process VIII) at E1/2 = -1.80 V (DeltaEp = 80 mV).	Iron	4-8	cytochrome c oxidase subunit 8A	Homo sapiens	226-230
24791141-8	2014	Retinal iron status in Tmprss6(msk/msk) mice was evaluated by comparing the expression levels of ferritin and transferrin receptor 1 between wild-type and knockout mice.	Iron	8-12	transmembrane serine protease 6	Mus musculus	23-30
24981681-1	2014	Zero-valent iron (Fe(0)) and magnetite (Fe3O4) were investigated as potential reductants in an electrokinetic/permeable reactive barrier hybrid system (EK/PRB) for the recovery of Cr as Cr(III) from Cr(VI)-contaminated kaolinite.	Iron	12-16	RB transcriptional corepressor 1	Homo sapiens	155-158
24573684-7	2014	The biochemical results highlight that the G50E mutation results in compromised interaction with the sulfur donor NFS1 and the J-protein HSCB, thus impairing the rate of Fe-S cluster synthesis.	Iron	170-174	NFS1 cysteine desulfurase	Homo sapiens	114-118
26373158-4	2015	From DRS results, MIL-53(Fe) samples prepared using microwave-assisted process displayed the absorption spectrum up to the visible region and then they showed the high photocatalytic activity under visible light irradiation.	Iron	25-27	sushi repeat containing protein X-linked	Homo sapiens	5-8
26074074-4	2015	Additionally, iron-induced degeneration of the retinal pigmented epithelium (RPE) is suppressed in mice lacking inflammasome components caspase-1/11 or Nlrp3 or by inhibition of caspase-1.	Iron	14-18	caspase 1	Mus musculus	136-148
24772084-3	2014	One way the host can transiently reduce iron bioavailability is by ferritin overexpression.	Iron	40-44	Ferritin 1 heavy chain homologue	Drosophila melanogaster	67-75
26074074-4	2015	Additionally, iron-induced degeneration of the retinal pigmented epithelium (RPE) is suppressed in mice lacking inflammasome components caspase-1/11 or Nlrp3 or by inhibition of caspase-1.	Iron	14-18	caspase 1	Mus musculus	136-145
25918158-2	2015	A secondary, non-catalytic, rubredoxin-like iron site is conserved in 3-hydroxyanthranilate 3,4-dioxygenase (HAO), from single cellular sources but not multicellular sources.	Iron	44-48	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	70-107
24508277-0	2014	F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.	Iron	71-75	F-box and leucine-rich repeat protein 5	Mus musculus	41-46
24508277-3	2014	F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, regulates cellular and systemic iron homeostasis by facilitating iron regulatory protein 2 (IRP2) degradation.	Iron	113-117	F-box and leucine-rich repeat protein 5	Mus musculus	41-46
24508277-4	2014	FBXL5 possesses an N-terminal hemerythrin (Hr)-like domain that mediates its own differential stability by switching between two different conformations to communicate cellular iron availability.	Iron	177-181	F-box and leucine-rich repeat protein 5	Mus musculus	0-5
24508277-6	2014	Mice lacking FBXL5 fail to sense intracellular iron levels and die in utero due to iron overload and exposure to damaging levels of oxidative stress.	Iron	47-51	F-box and leucine-rich repeat protein 5	Mus musculus	13-18
24508277-6	2014	Mice lacking FBXL5 fail to sense intracellular iron levels and die in utero due to iron overload and exposure to damaging levels of oxidative stress.	Iron	83-87	F-box and leucine-rich repeat protein 5	Mus musculus	13-18
24508277-8	2014	These findings suggest that FBXL5 is essential for the maintenance of iron homeostasis and is a key sensor of bioavailable iron.	Iron	70-74	F-box and leucine-rich repeat protein 5	Mus musculus	28-33
24508277-8	2014	These findings suggest that FBXL5 is essential for the maintenance of iron homeostasis and is a key sensor of bioavailable iron.	Iron	123-127	F-box and leucine-rich repeat protein 5	Mus musculus	28-33
25744855-4	2015	The S(BET) of energy cane biochar was negligible and increased to 37.13 m(2)/g after Fe(3+)/Fe(2+)/NaOH magnetization.	Iron	85-87	delta/notch like EGF repeat containing	Homo sapiens	6-9
24508277-9	2014	Here, we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology.	Iron	22-26	F-box and leucine-rich repeat protein 5	Mus musculus	64-69
26054392-0	2015	Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption.	Iron	79-83	homeostatic iron regulator	Homo sapiens	21-24
24489119-1	2014	ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N(6)-methyladenine in RNA.	Iron	37-49	alkB homolog 5, RNA demethylase	Homo sapiens	0-6
26054392-1	2015	BACKGROUND: HFE, a major regulator of iron (Fe) homeostasis, has been suggested to be under positive selection in both European and Asian populations.	Iron	38-42	homeostatic iron regulator	Homo sapiens	12-15
25649872-10	2015	These data suggest that Zip8 and Steap2 play a major role in iron accumulation from NTBI and TBI by hippocampal neurons.	Iron	61-65	solute carrier family 39 member 8	Rattus norvegicus	24-28
24111973-5	2014	Treatment with ABA also led to increased Fe concentrations in the xylem sap, partially because of the up-regulation of AtFRD3, AtYSL2 and AtNAS1, genes related to long-distance transport of Fe.	Iron	41-43	nicotianamine synthase 1	Arabidopsis thaliana	138-144
24111973-5	2014	Treatment with ABA also led to increased Fe concentrations in the xylem sap, partially because of the up-regulation of AtFRD3, AtYSL2 and AtNAS1, genes related to long-distance transport of Fe.	Iron	190-192	nicotianamine synthase 1	Arabidopsis thaliana	138-144
25649872-11	2015	Analysis of the expression and localization of known iron uptake transporters demonstrated that Zip8 makes a major contribution to iron accumulation in primary cultures of rat embryonic hippocampal neurons.	Iron	53-57	solute carrier family 39 member 8	Rattus norvegicus	96-100
24641804-9	2014	This iron-induced apoptosis was linked to enhanced caspase 8, reduced Bcl-2, Bcl-xL, phosphorylated Akt and GATA-4.	Iron	5-9	caspase 8	Homo sapiens	51-60
25649872-13	2015	Zip8 and Steap2 are strongly expressed in the plasma membrane of both soma and processes, implying a crucial role in iron accumulation from NTBI and transferrin-bound iron (TBI) by hippocampal neurons.	Iron	117-121	solute carrier family 39 member 8	Rattus norvegicus	0-4
24641804-11	2014	In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged.	Iron	3-7	caspase 8	Homo sapiens	77-86
25649872-13	2015	Zip8 and Steap2 are strongly expressed in the plasma membrane of both soma and processes, implying a crucial role in iron accumulation from NTBI and transferrin-bound iron (TBI) by hippocampal neurons.	Iron	167-171	solute carrier family 39 member 8	Rattus norvegicus	0-4
26042980-3	2015	In this study, malva nut gum (MNG), a new plant-based flocculant, and its composite with Fe in water treatment using single mode mixing are demonstrated.	Iron	89-91	NUT midline carcinoma family member 1	Homo sapiens	21-24
24653703-5	2014	This review focuses on the molecular actions of the HFE/Hfe and hepcidin in maintaining systemic iron homeostasis and approaches undertaken so far to combat iron overload in HFE/Hfe-HH.	Iron	97-101	homeostatic iron regulator	Homo sapiens	52-55
24653703-5	2014	This review focuses on the molecular actions of the HFE/Hfe and hepcidin in maintaining systemic iron homeostasis and approaches undertaken so far to combat iron overload in HFE/Hfe-HH.	Iron	97-101	homeostatic iron regulator	Homo sapiens	56-59
24586712-12	2014	These results suggest that iron reduction by DFO prevents renal tubulointerstitial fibrosis by regulating TGF-beta-Smad signaling, oxidative stress, and inflammatory responses.	Iron	27-31	transforming growth factor, beta 1	Mus musculus	106-114
25897079-0	2015	The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Iron	132-136	helicase for meiosis 1	Homo sapiens	57-65
25874809-6	2015	On the basis of these studies, the most probable mechanism for the inactivation of nNOS involves oxidative demethylation with the resulting thiol coordinating to the cofactor heme iron.	Iron	180-184	nitric oxide synthase 1	Homo sapiens	83-87
24028869-8	2014	Since lipocalins are known to bind regulatory fatty acids of channel proteins as well as iron, we suggest that the salt-induced trafficking of TIL may be required for protection of chloroplasts by affecting ion homeostasis.	Iron	89-93	temperature-induced lipocalin	Arabidopsis thaliana	143-146
24533143-1	2014	Although disruptions in the maintenance of iron and cholesterol metabolism have been implicated in several cancers, the association between variants in the HFE gene that is associated with cellular iron uptake and cholesterol metabolism has not been studied.	Iron	43-47	homeostatic iron regulator	Homo sapiens	156-159
24533143-1	2014	Although disruptions in the maintenance of iron and cholesterol metabolism have been implicated in several cancers, the association between variants in the HFE gene that is associated with cellular iron uptake and cholesterol metabolism has not been studied.	Iron	198-202	homeostatic iron regulator	Homo sapiens	156-159
24533143-2	2014	The C282Y-HFE variant is a risk factor for different cancers, is known to affect sphingolipid metabolism, and to result in increased cellular iron uptake.	Iron	142-146	homeostatic iron regulator	Homo sapiens	10-13
25970748-6	2015	Therefore, all of these data demonstrate that iron overload injures the hematopoiesis of BM by enhancing ROS through NOX4 and p38MAPK.	Iron	46-50	NADPH oxidase 4	Mus musculus	117-121
24604426-2	2014	The H63D and C282Y polymorphisms in the HFE gene may be involved in the development of sporadic amyotrophic lateral sclerosis (ALS) through the disruption of iron homeostasis.	Iron	158-162	homeostatic iron regulator	Homo sapiens	40-43
25970748-6	2015	Therefore, all of these data demonstrate that iron overload injures the hematopoiesis of BM by enhancing ROS through NOX4 and p38MAPK.	Iron	46-50	mitogen-activated protein kinase 14	Mus musculus	126-133
24048683-8	2014	Iron homeostasis is known to be perturbed in HCC and we observed downregulation of genes in this pathway.	Iron	0-4	HCC	Homo sapiens	45-48
25710710-7	2015	Iron deficiency suppresses erythropoietin production via the IRP1-HIF2alpha axis to prevent excessive iron usage by erythropoiesis during systemic iron restriction.	Iron	102-106	aconitase 1	Homo sapiens	61-65
24157279-5	2014	Furthermore, we confirmed that heavy-chain ferritin derived from CD14(+) monocytes suppresses Ig production in PBMCs, possibly through iron sequestration.	Iron	135-139	CD14 molecule	Homo sapiens	65-69
25710710-7	2015	Iron deficiency suppresses erythropoietin production via the IRP1-HIF2alpha axis to prevent excessive iron usage by erythropoiesis during systemic iron restriction.	Iron	147-151	aconitase 1	Homo sapiens	61-65
25767952-1	2015	PURPOSE OF REVIEW: The type 1 transferrin receptor (TfR1) is well known as a key player in erythroid differentiation through its role in iron uptake.	Iron	137-141	transferrin receptor	Homo sapiens	52-56
24144619-3	2014	Here, we report the presence of a [Fe-S] cluster directly within the active polymerase domain of Pol2 (residues 1-1187).	Iron	35-39	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	97-101
25983723-8	2015	Our data suggest that the interplay among JS1 bacteria, methanogenic archaea and Methanohalobium/ANME-3-related archaea may be important for iron reduction and methane cycling in deep methanic sediments of the Helgoland mud area and perhaps in other methane-rich depositional environments.	Iron	141-145	carboxymethylenebutenolidase homolog	Homo sapiens	42-45
24369906-6	2014	In vivo, Mb apparently forms a natural electrostatic complex with cytochrome b5 (cyt-b5) through the "dynamic" (loose) docking pattern, allowing for a slow ET that is intrinsically coupled to the water"s removal from the "defective" heme iron (altogether shaping the biological repair mechanism for Mb"s "met" form).	Iron	238-242	cytochrome b5 type A	Equus caballus	66-79
24369906-6	2014	In vivo, Mb apparently forms a natural electrostatic complex with cytochrome b5 (cyt-b5) through the "dynamic" (loose) docking pattern, allowing for a slow ET that is intrinsically coupled to the water"s removal from the "defective" heme iron (altogether shaping the biological repair mechanism for Mb"s "met" form).	Iron	238-242	cytochrome b5 type A	Equus caballus	81-87
25596185-4	2015	We report crystallographic analysis of hETHE1 in complex with iron to 2.6 A resolution.	Iron	62-66	ETHE1 persulfide dioxygenase	Homo sapiens	39-45
24333431-2	2014	Bacteria have three systems of [Fe-S] cluster biogenesis, designated ISC, NIF, and SUF.	Iron	32-36	S100 calcium binding protein A8	Homo sapiens	74-77
25596185-5	2015	hETHE1 contains an alphabetabetaalpha MBL-fold, which supports metal-binding by the side chains of an aspartate and two histidine residues; three water molecules complete octahedral coordination of the iron.	Iron	202-206	ETHE1 persulfide dioxygenase	Homo sapiens	0-6
25596185-6	2015	The iron binding hETHE1 enzyme is related to the "classical" di-zinc binding MBL hydrolases involved in antibiotic resistance, but has distinctive features.	Iron	4-8	ETHE1 persulfide dioxygenase	Homo sapiens	17-23
25596185-7	2015	The histidine and aspartate residues involved in iron-binding in ETHE1, occupy similar positions to those observed across both the zinc 1 and zinc 2 binding sites in classical MBLs.	Iron	49-53	ETHE1 persulfide dioxygenase	Homo sapiens	65-70
24864106-3	2014	In the cell the bioavailability of iron for the two main iron biological pathways--heme synthesis and the biogenesis of iron-sulfur clusters ([Fe-S])--is mainly regulated by the IRP/IRE posttranscriptional system.	Iron	35-39	Wnt family member 2	Homo sapiens	178-181
24864106-3	2014	In the cell the bioavailability of iron for the two main iron biological pathways--heme synthesis and the biogenesis of iron-sulfur clusters ([Fe-S])--is mainly regulated by the IRP/IRE posttranscriptional system.	Iron	57-61	Wnt family member 2	Homo sapiens	178-181
25628335-7	2015	This provides a potent mechanism by which frataxin, known to be involved in Fe-S cluster biosynthesis, could affect steroidogenesis through reduced ferredoxin activity.	Iron	76-80	frataxin	Drosophila melanogaster	42-50
24864106-3	2014	In the cell the bioavailability of iron for the two main iron biological pathways--heme synthesis and the biogenesis of iron-sulfur clusters ([Fe-S])--is mainly regulated by the IRP/IRE posttranscriptional system.	Iron	57-61	Wnt family member 2	Homo sapiens	178-181
24864106-3	2014	In the cell the bioavailability of iron for the two main iron biological pathways--heme synthesis and the biogenesis of iron-sulfur clusters ([Fe-S])--is mainly regulated by the IRP/IRE posttranscriptional system.	Iron	143-147	Wnt family member 2	Homo sapiens	178-181
25347084-7	2014	In animals fed with a control diet, the expression of three liver proteins involved in lipoprotein metabolism (ApoE), iron metabolism (Ftl), and regulation of nitric oxide generation (Ddah1) was up-regulated by the Pon1(-/-) genotype.	Iron	118-122	dimethylarginine dimethylaminohydrolase 1	Mus musculus	184-189
24275768-1	2014	PURPOSE OF REVIEW: Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide.	Iron	187-191	heme oxygenase 2	Homo sapiens	122-126
24141093-6	2014	(59)Fe uptake into the liver and spleen was significantly lower in iron-deficient Fth(Delta/Delta) than in Fth(lox/lox) mice 24 hours and 7 days after injection, respectively, and rapidly appeared in circulating erythrocytes instead.	Iron	4-6	lysyl oxidase	Mus musculus	111-114
24141093-6	2014	(59)Fe uptake into the liver and spleen was significantly lower in iron-deficient Fth(Delta/Delta) than in Fth(lox/lox) mice 24 hours and 7 days after injection, respectively, and rapidly appeared in circulating erythrocytes instead.	Iron	4-6	lysyl oxidase	Mus musculus	115-118
24154529-0	2013	Catalyst design for iron-promoted reductions: an iron disilyl-dicarbonyl complex bearing weakly coordinating eta2-(H-Si) moieties.	Iron	20-24	DNA polymerase iota	Homo sapiens	109-113
24373521-5	2013	Therefore, the effect of a single high iv dose of two different iron preparations, iron isomaltoside 1000 (IIM) and ferric carboxymaltose (FCM), on plasma levels of FGF23 and phosphate was examined in normal and uremic iron repleted rats.	Iron	64-68	fibroblast growth factor 23	Rattus norvegicus	165-170
24373521-5	2013	Therefore, the effect of a single high iv dose of two different iron preparations, iron isomaltoside 1000 (IIM) and ferric carboxymaltose (FCM), on plasma levels of FGF23 and phosphate was examined in normal and uremic iron repleted rats.	Iron	83-87	fibroblast growth factor 23	Rattus norvegicus	165-170
24055725-0	2013	PCB-77 disturbs iron homeostasis through regulating hepcidin gene expression.	Iron	16-20	pyruvate carboxylase	Mus musculus	0-3
24055725-2	2013	To date, little has been done to investigate the potential influence of PCB exposure on iron metabolism.	Iron	88-92	pyruvate carboxylase	Mus musculus	72-75
24055725-9	2013	Together, we deciphered the molecular mechanism responsible for PCB-conducted disturbance on iron homeostasis, i.e. through misregulating hepatic hepcidin expression.	Iron	93-97	pyruvate carboxylase	Mus musculus	64-67
24282296-6	2013	We definitively demonstrate, using genetic mouse models, that intestinal hypoxia-inducible factor-2alpha (HIF2alpha) and divalent metal transporter-1 (DMT1) are activated early in the pathogenesis of beta-thalassemia and are essential for excess iron accumulation in mouse models of beta-thalassemia.	Iron	246-250	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	121-149
24282296-6	2013	We definitively demonstrate, using genetic mouse models, that intestinal hypoxia-inducible factor-2alpha (HIF2alpha) and divalent metal transporter-1 (DMT1) are activated early in the pathogenesis of beta-thalassemia and are essential for excess iron accumulation in mouse models of beta-thalassemia.	Iron	246-250	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	151-155
24282296-9	2013	Mechanistic studies in a hemolytic anemia mouse model demonstrated that loss of intestinal HIF2alpha/DMT1 signaling led to decreased tissue-iron accumulation in the liver without worsening the anemia.	Iron	140-144	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	101-105
24324805-7	2013	Consistently, exogenous supplement of iron and VB12 greatly improved the anemia phenotype of MCPIP1(-/-) mice.	Iron	38-42	zinc finger CCCH type containing 12A	Mus musculus	93-99
24184271-2	2013	Over 85% of all cases with HH are due to mutations in the hemochromatosis protein (HFE) involved in iron metabolism.	Iron	100-104	homeostatic iron regulator	Homo sapiens	83-86
24184271-3	2013	Although the importance in iron homeostasis is well recognized, the mechanism of sensing and regulating iron absorption by HFE, especially in the absence of iron response element in its gene, is not fully understood.	Iron	104-108	homeostatic iron regulator	Homo sapiens	123-126
24184271-3	2013	Although the importance in iron homeostasis is well recognized, the mechanism of sensing and regulating iron absorption by HFE, especially in the absence of iron response element in its gene, is not fully understood.	Iron	104-108	homeostatic iron regulator	Homo sapiens	123-126
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	93-97	homeostatic iron regulator	Homo sapiens	59-62
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	93-97	homeostatic iron regulator	Homo sapiens	181-184
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	129-133	homeostatic iron regulator	Homo sapiens	59-62
24184271-7	2013	Thus, PARP1 binding to the inverted repeat sequence on the HFE promoter may serve as a novel iron sensing mechanism as increased iron level can trigger PARP1 cleavage and relief of HFE transcriptional repression.	Iron	129-133	homeostatic iron regulator	Homo sapiens	181-184
24156631-3	2013	This mechanism is further supported by the fact that Au NPs embedded in a matrix of butyl-3-methylimidazolium hexafluorophosphate for more efficient COOH* stabilization exhibit even higher reaction activity (3 A/g mass activity) and selectivity (97% FE) at -0.52 V (vs RHE).	Iron	250-252	factor interacting with PAPOLA and CPSF1	Homo sapiens	269-272
24036496-3	2013	METHODS AND RESULTS: Here we report that iron depots accumulate in human atherosclerotic plaque areas enriched in CD68 and mannose receptor (MR)-positive (CD68(+)MR(+)) alternative M2 macrophages.	Iron	41-45	mannose receptor C-type 1	Homo sapiens	123-139
24157963-6	2013	The discovery of these proteins and their interactions with "old friends," such as the 1st known hereditary hemochromatosis gene product, HFE and transferrin receptor, has opened the field of iron homeostasis to include regulatory networks involving signal transduction pathways, in particular, the mitogen-activated protein kinase and Smad pathways.	Iron	192-196	homeostatic iron regulator	Homo sapiens	138-141
24074834-11	2013	Furthermore, nutrient deficiencies including zinc, iron, cobalamin and vitamin C are associated with dysregulation of Ca(v)3.2 T-channels and N-methyl-D-aspartate receptors, upregulation of nitric oxide synthase, the increase of nitric oxide formation and dysfunction of central norepinephrine inhibitory pain pathway.	Iron	51-55	caveolin 3	Homo sapiens	118-124
24056782-5	2013	The results demonstrated that iron homeostasis is disturbed in the absence of CCC2 under copper deficient conditions and also revealed the importance of this gene in the maintenance of iron homeostasis under high copper conditions.	Iron	30-34	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	78-82
24066857-3	2013	The MCD spectrum of biferrous MIOX shows two ligand field (LF) transitions near 10000 cm(-1), split by ~2000 cm(-1), characteristic of six coordinate (6C) Fe(II) sites, indicating that the modest reactivity of the biferrous form toward O2 can be attributed to the saturated coordination of both irons.	Iron	295-300	myo-inositol oxygenase	Homo sapiens	30-34
24045011-2	2013	One of the early actors in Fe-S cluster biosynthesis is a protein complex composed of a cysteine desulphurase, Nfs1, and its functional binding partner, Isd11.	Iron	27-31	NFS1 cysteine desulfurase	Homo sapiens	111-115
24146952-7	2013	Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN).	Iron	12-16	transferrin receptor	Mus musculus	177-197
24146952-7	2013	Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN).	Iron	12-16	transferrin receptor	Mus musculus	199-202
23946486-0	2013	Binding of the chaperone Jac1 protein and cysteine desulfurase Nfs1 to the iron-sulfur cluster scaffold Isu protein is mutually exclusive.	Iron	75-79	NFS1 cysteine desulfurase	Homo sapiens	63-67
24877740-3	2014	Expression of iron handling proteins can also be translationally regulated by binding of iron regulatory protein (IRP) to iron responsive elements (IREs) on the mRNA of ferritin chains and transferrin receptor (TfR).	Iron	14-18	Wnt family member 2	Homo sapiens	89-112
24877740-3	2014	Expression of iron handling proteins can also be translationally regulated by binding of iron regulatory protein (IRP) to iron responsive elements (IREs) on the mRNA of ferritin chains and transferrin receptor (TfR).	Iron	14-18	Wnt family member 2	Homo sapiens	114-117
24877740-3	2014	Expression of iron handling proteins can also be translationally regulated by binding of iron regulatory protein (IRP) to iron responsive elements (IREs) on the mRNA of ferritin chains and transferrin receptor (TfR).	Iron	14-18	transferrin receptor	Homo sapiens	189-209
24877740-3	2014	Expression of iron handling proteins can also be translationally regulated by binding of iron regulatory protein (IRP) to iron responsive elements (IREs) on the mRNA of ferritin chains and transferrin receptor (TfR).	Iron	14-18	transferrin receptor	Homo sapiens	211-214
24877740-3	2014	Expression of iron handling proteins can also be translationally regulated by binding of iron regulatory protein (IRP) to iron responsive elements (IREs) on the mRNA of ferritin chains and transferrin receptor (TfR).	Iron	89-93	Wnt family member 2	Homo sapiens	114-117
24877740-3	2014	Expression of iron handling proteins can also be translationally regulated by binding of iron regulatory protein (IRP) to iron responsive elements (IREs) on the mRNA of ferritin chains and transferrin receptor (TfR).	Iron	89-93	transferrin receptor	Homo sapiens	211-214
24920569-1	2014	Friedreich"s ataxia (FRDA) is linked to a deficiency of frataxin (FXN), a mitochondrial protein involved in iron-sulfur cluster synthesis.	Iron	108-112	frataxin	Homo sapiens	56-64
24920569-1	2014	Friedreich"s ataxia (FRDA) is linked to a deficiency of frataxin (FXN), a mitochondrial protein involved in iron-sulfur cluster synthesis.	Iron	108-112	frataxin	Homo sapiens	66-69
24717297-4	2014	Chlormethiazole, a specific CYP2E1 transcription inhibitor, prevented an increase in catalytic iron in the kidneys, decreased oxidative stress, blocked nuclear translocation of the Nrf2 protein, decreased heme oxygenase-1 upregulation, and provided functional and histological protection against acute kidney injury.	Iron	95-99	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	28-34
24889527-8	2014	Furthermore, we showed that MED16 interacted with FIT and improved the binding of the FIT/Ib bHLH complex to FRO2 and IRT1 promoters under iron-deficient conditions.	Iron	139-143	sensitive to freezing 6	Arabidopsis thaliana	28-33
24889527-8	2014	Furthermore, we showed that MED16 interacted with FIT and improved the binding of the FIT/Ib bHLH complex to FRO2 and IRT1 promoters under iron-deficient conditions.	Iron	139-143	ferric reduction oxidase 2	Arabidopsis thaliana	109-113
24889527-9	2014	Additionally, we found that many iron-deficient response genes, which are regulated by FIT, were also controlled by MED16.	Iron	33-37	sensitive to freezing 6	Arabidopsis thaliana	116-121
24889527-10	2014	In conclusion, MED16 is involved in the iron deficiency response, and modulates the iron uptake gene expression under iron limitation.	Iron	40-44	sensitive to freezing 6	Arabidopsis thaliana	15-20
24889527-10	2014	In conclusion, MED16 is involved in the iron deficiency response, and modulates the iron uptake gene expression under iron limitation.	Iron	84-88	sensitive to freezing 6	Arabidopsis thaliana	15-20
24889527-10	2014	In conclusion, MED16 is involved in the iron deficiency response, and modulates the iron uptake gene expression under iron limitation.	Iron	84-88	sensitive to freezing 6	Arabidopsis thaliana	15-20
24904115-0	2014	Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis.	Iron	114-118	transmembrane serine protease 6	Mus musculus	0-12
25071582-3	2014	In the iron field, variants in the HFE gene that give rise to a protein involved in cellular iron regulation, are associated with iron accumulation in multiple organs including the brain.	Iron	7-11	homeostatic iron regulator	Homo sapiens	35-38
25071582-3	2014	In the iron field, variants in the HFE gene that give rise to a protein involved in cellular iron regulation, are associated with iron accumulation in multiple organs including the brain.	Iron	93-97	homeostatic iron regulator	Homo sapiens	35-38
25071582-3	2014	In the iron field, variants in the HFE gene that give rise to a protein involved in cellular iron regulation, are associated with iron accumulation in multiple organs including the brain.	Iron	93-97	homeostatic iron regulator	Homo sapiens	35-38
25071582-10	2014	It highlights the effects of gene variants of HFE (H63D- and C282Y-HFE) on iron and cholesterol metabolism and how they may contribute to understanding the etiology of complex neurodegenerative diseases.	Iron	75-79	homeostatic iron regulator	Homo sapiens	46-49
25071582-10	2014	It highlights the effects of gene variants of HFE (H63D- and C282Y-HFE) on iron and cholesterol metabolism and how they may contribute to understanding the etiology of complex neurodegenerative diseases.	Iron	75-79	homeostatic iron regulator	Homo sapiens	66-70
25117103-1	2014	Mutations of the HAMP gene and HFE gene have a role in iron overload.	Iron	55-59	homeostatic iron regulator	Homo sapiens	31-34
24185077-3	2014	However PRB-ZVI technology is affected by some problems such as the long-term performance decrease, loss of porosity and no applicability to some important compounds, such as 1,2-dichloroetane (1,2-DCA).	Iron	12-15	RB transcriptional corepressor 1	Homo sapiens	8-11
24185077-4	2014	In this study we wanted to investigate whether the coupling of ZVI with a long-lasting slow-release substrate (i.e. poly-hydroxybutyrate, PHB) could be a strategy to enhance the degradation performance of ZVI barriers towards chlorinated ethanes especially stimulating biological reductive dechlorination downgradient the PRB.	Iron	63-66	prohibitin 1	Homo sapiens	138-141
24185077-4	2014	In this study we wanted to investigate whether the coupling of ZVI with a long-lasting slow-release substrate (i.e. poly-hydroxybutyrate, PHB) could be a strategy to enhance the degradation performance of ZVI barriers towards chlorinated ethanes especially stimulating biological reductive dechlorination downgradient the PRB.	Iron	63-66	RB transcriptional corepressor 1	Homo sapiens	322-325
24185077-4	2014	In this study we wanted to investigate whether the coupling of ZVI with a long-lasting slow-release substrate (i.e. poly-hydroxybutyrate, PHB) could be a strategy to enhance the degradation performance of ZVI barriers towards chlorinated ethanes especially stimulating biological reductive dechlorination downgradient the PRB.	Iron	205-208	prohibitin 1	Homo sapiens	138-141
24185077-4	2014	In this study we wanted to investigate whether the coupling of ZVI with a long-lasting slow-release substrate (i.e. poly-hydroxybutyrate, PHB) could be a strategy to enhance the degradation performance of ZVI barriers towards chlorinated ethanes especially stimulating biological reductive dechlorination downgradient the PRB.	Iron	205-208	RB transcriptional corepressor 1	Homo sapiens	322-325
24917819-0	2014	Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.	Iron	26-30	frataxin	Homo sapiens	45-62
24917819-0	2014	Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.	Iron	77-81	frataxin	Homo sapiens	45-62
24917819-0	2014	Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.	Iron	77-81	frataxin	Homo sapiens	45-62
24917819-4	2014	In the recent past years, considerable progress in understanding the function of frataxin has been provided through cellular and biochemical approaches, pointing to the primary role of frataxin in iron-sulfur cluster biogenesis.	Iron	197-201	frataxin	Homo sapiens	81-89
24917819-4	2014	In the recent past years, considerable progress in understanding the function of frataxin has been provided through cellular and biochemical approaches, pointing to the primary role of frataxin in iron-sulfur cluster biogenesis.	Iron	197-201	frataxin	Homo sapiens	185-193
24917819-5	2014	However, why and how the impact of frataxin deficiency on this essential biosynthetic pathway leads to mitochondrial iron accumulation is still poorly understood.	Iron	117-121	frataxin	Homo sapiens	35-43
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	48-52	eukaryotic translation initiation factor 5A2	Homo sapiens	177-208
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	104-108	eukaryotic translation initiation factor 5A2	Homo sapiens	177-208
24565801-15	2014	In cast iron pipes a high relative abundance of bacteria able to utilise different iron and manganese compounds were found such as Lysinibacillus spp., Geobacillus spp.	Iron	8-12	histocompatibility minor 13	Homo sapiens	146-149
24565801-15	2014	In cast iron pipes a high relative abundance of bacteria able to utilise different iron and manganese compounds were found such as Lysinibacillus spp., Geobacillus spp.	Iron	8-12	histocompatibility minor 13	Homo sapiens	164-167
24565801-15	2014	In cast iron pipes a high relative abundance of bacteria able to utilise different iron and manganese compounds were found such as Lysinibacillus spp., Geobacillus spp.	Iron	83-87	histocompatibility minor 13	Homo sapiens	146-149
24565801-15	2014	In cast iron pipes a high relative abundance of bacteria able to utilise different iron and manganese compounds were found such as Lysinibacillus spp., Geobacillus spp.	Iron	83-87	histocompatibility minor 13	Homo sapiens	164-167
24131232-1	2014	SIGNIFICANCE: Heme oxygenases (HO-1 and HO-2) catalyze the degradation of the pro-oxidant heme into carbon monoxide (CO), iron, and biliverdin, which is subsequently converted to bilirubin.	Iron	122-126	heme oxygenase 2	Homo sapiens	40-44
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Iron	197-199	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Iron	197-199	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Iron	197-199	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24398642-4	2014	RESULTS: We found strong associations between HFE and TMPRSS6 genotypes and mother"s haemoglobin levels early in pregnancy (P-values are all &lt;= 4.1 x 10(-5)) and a genetic score comprised of alleles at these loci was even more strongly associated with haemoglobin levels (P=3.0 x 10(-18)), suggesting that this was a good instrument to use to look at the effect of prenatal iron levels on offspring cognition.	Iron	377-381	homeostatic iron regulator	Homo sapiens	46-49
24365882-2	2014	Iron uptake is controlled by iron transport proteins such as transferrin receptors (TfRs) and lipocalin 2 (LCN-2).	Iron	0-4	lipocalin 2	Rattus norvegicus	94-105
24365882-2	2014	Iron uptake is controlled by iron transport proteins such as transferrin receptors (TfRs) and lipocalin 2 (LCN-2).	Iron	0-4	lipocalin 2	Rattus norvegicus	107-112
24365882-2	2014	Iron uptake is controlled by iron transport proteins such as transferrin receptors (TfRs) and lipocalin 2 (LCN-2).	Iron	29-33	lipocalin 2	Rattus norvegicus	107-112
24365882-9	2014	Concomitantly, gene expression of LCN-2 and ferritin subunits (light- and heavy-chain ferritin subunits) was upregulated by iron or/and AP cytokines with a maximum at 24 h both at mRNA and protein levels.	Iron	124-128	lipocalin 2	Rattus norvegicus	34-39
24365882-10	2014	In contrast, a decreased TfR1 level was detected by IL-6 and iron alone, whereas combination of iron and AP cytokines (mainly IL-6) abrogated the downregulation of TfR1.	Iron	61-65	transferrin receptor	Rattus norvegicus	25-29
24564785-2	2014	In the case of LiFexMn1-xPO4, for example, in micrometer-sized particles synthesized via hydrothermal route, two separate redox centers corresponding to Fe(2+)/Fe(3+) (3.5 V vs Li/Li(+)) and Mn(2+)/Mn(3+) (4.1 V vs Li/Li(+)), due to the collective Mn-O-Fe interactions in the olivine lattice, are commonly observed in the electrochemical measurements.	Iron	17-19	exportin 4	Homo sapiens	24-28
24564785-2	2014	In the case of LiFexMn1-xPO4, for example, in micrometer-sized particles synthesized via hydrothermal route, two separate redox centers corresponding to Fe(2+)/Fe(3+) (3.5 V vs Li/Li(+)) and Mn(2+)/Mn(3+) (4.1 V vs Li/Li(+)), due to the collective Mn-O-Fe interactions in the olivine lattice, are commonly observed in the electrochemical measurements.	Iron	153-155	exportin 4	Homo sapiens	24-28
25006473-11	2014	Oral iron therapy led to statistically significant improvement in hemoglobin, red cell indices (P &lt; 0.05), and marked change in serum iron, ferritin, and HbA2 levels (P &lt; 0.001).	Iron	5-9	hemoglobin subunit alpha 2	Homo sapiens	157-161
23901875-0	2014	Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor.	Iron	22-26	furin, paired basic amino acid cleaving enzyme	Homo sapiens	74-79
23901875-6	2014	The furin inhibitor (FI) decreases furin-mediated proteolytic cleavage of mHJV into sHJV and augments the mHJV/sHJV ratio after iron overload with hypoxia condition.	Iron	128-132	furin, paired basic amino acid cleaving enzyme	Homo sapiens	4-9
24624085-1	2014	Growing evidence supports a role for mitochondrial iron metabolism in the pathophysiology of neurodegenerative disorders such as Friedreich ataxia (FRDA) and Parkinson disease (PD) as well as in the motor and cognitive decline associated with the aging process.	Iron	51-55	frataxin	Homo sapiens	129-146
24624085-1	2014	Growing evidence supports a role for mitochondrial iron metabolism in the pathophysiology of neurodegenerative disorders such as Friedreich ataxia (FRDA) and Parkinson disease (PD) as well as in the motor and cognitive decline associated with the aging process.	Iron	51-55	frataxin	Homo sapiens	148-152
24624085-5	2014	Targeting chelatable iron and reactive oxygen species appear as possible therapeutic options for FRDA and PD, and possibly other age-related neurodegenerative conditions.	Iron	21-25	frataxin	Homo sapiens	97-101
24083991-0	2014	Iron overload induces changes of pancreatic and duodenal divalent metal transporter 1 and prohepcidin expression in mice.	Iron	0-4	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	57-85
24083991-7	2014	In the iron overloaded mice, prohepcidin expression increased in islets of Langerhans and hepatocytes, and divalent metal transporter 1 expression decreased in cells of islets and in enterocytes.	Iron	7-11	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	107-135
24083991-9	2014	The inverse relationship between divalent metal transporter 1 and prohepcidin may indicate a negative regulation by hepcidin, and hence reduction of iron stores in islets of Langerhans.	Iron	149-153	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	33-61
24503941-4	2014	Genetic testing for mutations in the HFE (high iron) gene and other proteins, such as hemojuvelin, transferrin receptor, and ferroportin, should be performed if secondary causes of iron overload are ruled out.	Iron	47-51	homeostatic iron regulator	Homo sapiens	37-40
23771608-10	2013	These results suggest that 6-OHDA might promote iron transport rate in astrocytes by regulating iron transporters, IRP1 expression and NF-kappaB p65 activation, indicating a different response between neurons and astrocytes.	Iron	48-52	aconitase 1	Homo sapiens	115-119
23771608-10	2013	These results suggest that 6-OHDA might promote iron transport rate in astrocytes by regulating iron transporters, IRP1 expression and NF-kappaB p65 activation, indicating a different response between neurons and astrocytes.	Iron	48-52	RELA proto-oncogene, NF-kB subunit	Homo sapiens	135-148
23615502-1	2013	Hepcidin, the key regulatory hormone of iron homeostasis, and iron carriers such as transferrin receptor1 (TFR1), divalent metal transporter1 (DMT1), and ferroportin (FPN) are expressed in kidney.	Iron	62-66	transferrin receptor	Mus musculus	84-105
23615502-1	2013	Hepcidin, the key regulatory hormone of iron homeostasis, and iron carriers such as transferrin receptor1 (TFR1), divalent metal transporter1 (DMT1), and ferroportin (FPN) are expressed in kidney.	Iron	62-66	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	114-141
23935105-5	2013	FANCJ belongs to a conserved iron-sulfur (Fe S) cluster family of helicases important for genomic stability including XPD (nucleotide excision repair), DDX11 (sister chromatid cohesion), and RTEL (telomere metabolism), genetically linked to xeroderma pigmentosum/Cockayne syndrome, Warsaw breakage syndrome, and dyskeratosis congenita, respectively.	Iron	29-33	regulator of telomere elongation helicase 1	Homo sapiens	191-195
23845776-5	2013	Hemochromatosis gene (HFE) mutations namely C282Y and H63D may cause hepatic iron overload, thus increasing the risk of HCC in HCV patients.	Iron	77-81	homeostatic iron regulator	Homo sapiens	22-25
23845776-5	2013	Hemochromatosis gene (HFE) mutations namely C282Y and H63D may cause hepatic iron overload, thus increasing the risk of HCC in HCV patients.	Iron	77-81	HCC	Homo sapiens	120-123
24065958-2	2013	Similar to humans with insulin resistance, managed bottlenose dolphins (Tursiops truncatus) diagnosed with hemochromatosis (iron overload) have higher levels of 2 h post-prandial plasma insulin than healthy controls.	Iron	124-128	insulin	Tursiops truncatus	186-193
23959881-4	2013	NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria.	Iron	92-96	max binding protein	Mus musculus	64-67
23959881-5	2013	Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy.	Iron	305-309	max binding protein	Mus musculus	50-53
24503941-4	2014	Genetic testing for mutations in the HFE (high iron) gene and other proteins, such as hemojuvelin, transferrin receptor, and ferroportin, should be performed if secondary causes of iron overload are ruled out.	Iron	181-185	homeostatic iron regulator	Homo sapiens	37-40
25833890-6	2015	The same method was used to calculate adjustment factors for soluble transferrin receptor (sTfR) and body iron stores (BISs) in Lao children.	Iron	106-110	interleukin 4 induced 1	Homo sapiens	128-131
24901155-9	2014	These results suggest that TfR is expressed in response to iron deficiency during liver carcinogenesis.	Iron	59-63	transferrin receptor	Homo sapiens	27-30
24343647-5	2014	Lcn2 plays a key role in preventing iron acquisition by bacteria that use catecholate-type siderophores, and lipocalin 2(-/-) mice are highly susceptible to infection by Escherichia coli and Klebsiella pneumoniae.	Iron	36-40	lipocalin 2	Mus musculus	0-4
23259530-3	2013	1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro using glutathione (GSH) as cofactor.	Iron	71-75	glutaredoxin	Homo sapiens	4-8
25428262-4	2015	Genes significantly differentially expressed at the transcript and/or exon level in SF3B1 mutant compared with wild-type cases include genes that are involved in MDS pathogenesis (ASXL1 and CBL), iron homeostasis and mitochondrial metabolism (ALAS2, ABCB7 and SLC25A37) and RNA splicing/processing (PRPF8 and HNRNPD).	Iron	196-200	splicing factor 3b subunit 1	Homo sapiens	84-89
23991213-6	2013	RESULTS: In a panel of HNSCC cell lines, hemochromatosis (HFE) was one of the most overexpressed genes involved in iron regulation.	Iron	115-119	homeostatic iron regulator	Homo sapiens	58-61
23991213-7	2013	In vitro knockdown of HFE in HNSCC cell lines significantly decreased hepcidin (HAMP) expression and intracellular iron level.	Iron	115-119	homeostatic iron regulator	Homo sapiens	22-25
23991213-9	2013	These cellular changes were reversed by re-introducing iron back into HNSCC cells after HFE knockdown, indicating that iron was mediating this phenotype.	Iron	55-59	homeostatic iron regulator	Homo sapiens	88-91
23991213-12	2013	CONCLUSIONS: Our data identify HFE as potentially novel prognostic marker in HNSCC that promotes tumour progression via HAMP and elevated intracellular iron levels, leading to increased cellular proliferation and tumour formation.	Iron	152-156	homeostatic iron regulator	Homo sapiens	31-34
24420575-5	2014	The transcript levels of NtIRT1 and NtZIP1 were higher in transgenic plants, indicating an induction of the Fe and Zn deficiency status due to AtHMA4 expression.	Iron	108-110	heavy metal atpase 4	Arabidopsis thaliana	143-149
25591911-3	2015	In the present study, pretreatment of U373MG human astrocytoma cells with an iron chelator desferrioxamine (DFX) inhibited the expression of CXCL10 induced by a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC).	Iron	77-81	toll like receptor 3	Homo sapiens	161-181
24344252-4	2014	Both WAP65 and HPX have been associated with iron homeostasis due to the affinity to bind the toxic-free heme circulating in the blood stream.	Iron	45-49	hemopexin	Homo sapiens	15-18
23891004-5	2013	In contrast, CIA2A specifically matures iron regulatory protein 1 (IRP1), which is critical for cellular iron homeostasis.	Iron	40-44	aconitase 1	Homo sapiens	67-71
23891004-7	2013	In summary, CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization.	Iron	140-144	aconitase 1	Homo sapiens	160-164
25591911-3	2015	In the present study, pretreatment of U373MG human astrocytoma cells with an iron chelator desferrioxamine (DFX) inhibited the expression of CXCL10 induced by a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC).	Iron	77-81	toll like receptor 3	Homo sapiens	183-187
23744990-3	2013	In vitro incubation of human or murine macrophages with SR-AI-targeted USPIO led to significantly higher iron uptake in vitro than with nontargeted USPIO, as judged by quantitative atomic absorption spectroscopy and Perl"s staining.	Iron	105-109	macrophage scavenger receptor 1	Mus musculus	56-61
24456400-3	2014	We identified a T-DNA insertion mutant, yellow and sensitive to iron-deficiency 1 (yid1), that was hypersensitive to iron deficiency, containing a reduced amount of iron.	Iron	64-68	sensitive to freezing 6	Arabidopsis thaliana	83-87
24456400-3	2014	We identified a T-DNA insertion mutant, yellow and sensitive to iron-deficiency 1 (yid1), that was hypersensitive to iron deficiency, containing a reduced amount of iron.	Iron	117-121	sensitive to freezing 6	Arabidopsis thaliana	83-87
24456400-8	2014	In particular, the transcription levels of FIT, IRT1 and FRO2 were reduced in the yid1 and med25 mutants under iron-deficient conditions.	Iron	111-115	ferric reduction oxidase 2	Arabidopsis thaliana	57-61
24456400-8	2014	In particular, the transcription levels of FIT, IRT1 and FRO2 were reduced in the yid1 and med25 mutants under iron-deficient conditions.	Iron	111-115	sensitive to freezing 6	Arabidopsis thaliana	82-86
24456400-9	2014	The finding that YID1/MED16 and MED25 positively regulate iron homeostasis in Arabidopsis increases our understanding of the complex transcriptional regulation of iron homeostasis in plants.	Iron	58-62	sensitive to freezing 6	Arabidopsis thaliana	17-21
25686467-15	2015	This study also unearthed a PCB-mediated connection linking estrogen-like activity, iron effects, and lipid homeostasis.	Iron	84-88	pyruvate carboxylase	Mus musculus	28-31
24456400-9	2014	The finding that YID1/MED16 and MED25 positively regulate iron homeostasis in Arabidopsis increases our understanding of the complex transcriptional regulation of iron homeostasis in plants.	Iron	58-62	sensitive to freezing 6	Arabidopsis thaliana	22-27
24456400-9	2014	The finding that YID1/MED16 and MED25 positively regulate iron homeostasis in Arabidopsis increases our understanding of the complex transcriptional regulation of iron homeostasis in plants.	Iron	163-167	sensitive to freezing 6	Arabidopsis thaliana	17-21
24456400-9	2014	The finding that YID1/MED16 and MED25 positively regulate iron homeostasis in Arabidopsis increases our understanding of the complex transcriptional regulation of iron homeostasis in plants.	Iron	163-167	sensitive to freezing 6	Arabidopsis thaliana	22-27
23771129-2	2013	The primary function of ferritin is to store bioavailable iron in the form of ferrihydrite.	Iron	58-62	Ferritin 1 heavy chain homologue	Drosophila melanogaster	24-32
23771129-3	2013	In animals, ferritin is also used to traffic and recycle iron, and to modulate intestinal iron absorption.	Iron	57-61	Ferritin 1 heavy chain homologue	Drosophila melanogaster	12-20
23771129-3	2013	In animals, ferritin is also used to traffic and recycle iron, and to modulate intestinal iron absorption.	Iron	90-94	Ferritin 1 heavy chain homologue	Drosophila melanogaster	12-20
23771129-4	2013	However, the effect of ferritin accumulation on cellular iron bioavailability remains poorly understood.	Iron	57-61	Ferritin 1 heavy chain homologue	Drosophila melanogaster	23-31
23771129-7	2013	Quantitative magnetic analysis of whole fly samples indicated that iron loading of the ferritin core varied in the different genotypes.	Iron	67-71	Ferritin 1 heavy chain homologue	Drosophila melanogaster	87-95
23771129-8	2013	Total paramagnetic iron content, a likely correlate of bioavailable iron, was reduced in flies overexpressing ferritin when compared with control white flies.	Iron	19-23	Ferritin 1 heavy chain homologue	Drosophila melanogaster	110-118
23771129-8	2013	Total paramagnetic iron content, a likely correlate of bioavailable iron, was reduced in flies overexpressing ferritin when compared with control white flies.	Iron	68-72	Ferritin 1 heavy chain homologue	Drosophila melanogaster	110-118
24634837-5	2014	The expression of the iron-importing transport proteins divalent metal transporter 1 and transferrin receptor 1 was induced, while hepatic and splenic inflammatory markers were not affected in the curcumin-fed mice.	Iron	22-26	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	56-111
24909164-0	2015	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.	Iron	25-29	aconitase 1	Homo sapiens	73-98
24533165-3	2014	We found that iron efflux from hBMVEC through the ferrous iron permease ferroportin (Fpn) was stimulated by secretion of the soluble form of the multi-copper ferroxidase, ceruloplasmin (sCp) from the co-cultured C6 cells.	Iron	14-18	urocortin 3	Homo sapiens	186-189
23771129-12	2013	Our results indicate that ferritin may be involved in the homeostasis of other divalent metals, besides iron, and that overexpression of ferritin, sometimes employed to rescue neurodegenerative models of disease, serves to limit divalent metal bio-availability in cells.	Iron	104-108	Ferritin 1 heavy chain homologue	Drosophila melanogaster	26-34
24909164-3	2015	Here, we report that mitochondrial SIRT3 regulates cellular iron metabolism by modulating IRP1 activity.	Iron	60-64	aconitase 1	Homo sapiens	90-94
25790062-6	2015	The MTS reaction using a constitutional isomer of for-HBH that transposed the methylene unit to the carboxylic acid containing region, 5-[(5-aminopentyl)(hydroxy)amino]-5-oxopentanoic acid (for-PPH), gave the macrocycle for-[Fe(HPDFOE)] in a yield significantly less than that for for-[Fe(HHDFOE)], with the gallium(III) analogue for-[Ga(HPDFOE)] unable to be detected.	Iron	225-227	hemoglobin subunit alpha 1	Homo sapiens	54-57
23908604-1	2013	Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability.	Iron	23-27	lipocalin 2	Mus musculus	0-11
23908604-1	2013	Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability.	Iron	23-27	lipocalin 2	Mus musculus	13-17
24422557-6	2014	Previous study showed that Pyrococcus horikoshii Dph2 (PhDph2), a novel iron-sulfur cluster-containing enzyme, forms a homodimer and is sufficient for the first step of diphthamide biosynthesis in vitro.	Iron	72-76	diphthamide biosynthesis 2	Homo sapiens	49-53
24422557-8	2014	We further demonstrate that yeast Dph3 (also known as KTI11), a CSL-type zinc finger protein, can bind iron and in the reduced state can serve as an electron donor to reduce the Fe-S cluster in Dph1-Dph2.	Iron	103-107	diphthamide biosynthesis 2	Homo sapiens	199-203
24422557-8	2014	We further demonstrate that yeast Dph3 (also known as KTI11), a CSL-type zinc finger protein, can bind iron and in the reduced state can serve as an electron donor to reduce the Fe-S cluster in Dph1-Dph2.	Iron	178-182	diphthamide biosynthesis 2	Homo sapiens	199-203
24422557-11	2014	The finding that Dph3 is an electron donor for the Fe-S clusters in Dph1-Dph2 is thus interesting and opens up new avenues of research on electron transfer to Fe-S proteins in eukaryotic cells.	Iron	51-55	diphthamide biosynthesis 2	Homo sapiens	73-77
24422557-11	2014	The finding that Dph3 is an electron donor for the Fe-S clusters in Dph1-Dph2 is thus interesting and opens up new avenues of research on electron transfer to Fe-S proteins in eukaryotic cells.	Iron	159-163	diphthamide biosynthesis 2	Homo sapiens	73-77
25662334-6	2015	Furthermore, C326S ferroportin mutant mice with a disrupted hepcidin/ferroportin regulatory circuitry respond to injection of the TLR2/6 ligands FSL1 or PAM3CSK4 by ferroportin downregulation and a reduction of serum iron levels.	Iron	217-221	toll-like receptor 2	Mus musculus	130-134
24382354-5	2014	Overexpression of ABCB8, a mitochondrial protein that facilitates iron export, in vitro and in the hearts of transgenic mice decreased mitochondrial iron and cellular ROS and protected against doxorubicin-induced cardiomyopathy.	Iron	66-70	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	18-23
24382354-5	2014	Overexpression of ABCB8, a mitochondrial protein that facilitates iron export, in vitro and in the hearts of transgenic mice decreased mitochondrial iron and cellular ROS and protected against doxorubicin-induced cardiomyopathy.	Iron	149-153	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	18-23
25841232-0	2015	HFE gene mutation and oxidative damage biomarkers in patients with myelodysplastic syndromes and its relation to transfusional iron overload: an observational cross-sectional study.	Iron	127-131	homeostatic iron regulator	Homo sapiens	0-3
23893294-6	2014	We found that CBD rescued iron-induced effects, bringing hippocampal DNM1L, caspase 3, and synaptophysin levels back to values comparable to the control group.	Iron	26-30	caspase 3	Rattus norvegicus	76-85
24383984-6	2014	Importantly, SIV Nef-induced inhibition of TfR endocytosis leads to the reduction of Transferrin uptake and intracellular iron concentration and is accompanied by attenuated lentiviral replication in macrophages.	Iron	122-126	transferrin receptor	Homo sapiens	43-46
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	126-130	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	153-181
25780429-6	2015	It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	126-130	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	183-187
25780429-9	2015	A significant increase was observed in the levels of DMT1-iron-responsive element (IRE) and DMT1-nonIRE in the hippocampus of the AD mouse brain, which was reduced by treatment with the active components.	Iron	58-62	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	53-57
25147792-0	2014	The N-terminal domain of human DNA helicase Rtel1 contains a redox active iron-sulfur cluster.	Iron	74-78	regulator of telomere elongation helicase 1	Homo sapiens	44-49
25550467-6	2015	Although iron in excess, known to increase reactive oxygen species production, and iron depletion both resulted in decreased ACO1 mRNA levels and activity, Aco1 KD led to reduced gene expression of transferrin receptor (Tfrc) and transferrin, disrupting intracellular iron uptake.	Iron	83-87	aconitase 1	Homo sapiens	125-129
25147792-2	2014	Here we report that the N-terminal domain of human Rtel1 (RtelN) expressed in Escherichia coli cells produces a protein that contains a redox active iron-sulfur cluster with the redox midpoint potential of -248 +- 10 mV (pH 8.0).	Iron	149-153	regulator of telomere elongation helicase 1	Homo sapiens	51-56
25550467-6	2015	Although iron in excess, known to increase reactive oxygen species production, and iron depletion both resulted in decreased ACO1 mRNA levels and activity, Aco1 KD led to reduced gene expression of transferrin receptor (Tfrc) and transferrin, disrupting intracellular iron uptake.	Iron	83-87	aconitase 1	Homo sapiens	156-160
25147792-3	2014	The iron-sulfur cluster in RtelN is sensitive to hydrogen peroxide and nitric oxide, indicating that reactive oxygen/nitrogen species may modulate the DNA helicase activity of Rtel1 via modification of its iron-sulfur cluster.	Iron	4-8	regulator of telomere elongation helicase 1	Homo sapiens	176-181
25550467-9	2015	Altogether, these results suggest that ACO1 activity is required for the normal adipogenic capacity of adipose tissue by connecting iron, energy metabolism, and adipogenesis.	Iron	132-136	aconitase 1	Homo sapiens	39-43
25575693-8	2015	We conclude that in AD damage occurs in conjunction with iron accumulation, and the brain iron load associated with loss control of the brain iron metabolism related protein DMT1 and FPN1 expressions.	Iron	90-94	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	174-178
23943793-4	2014	These Fe-S cluster-deficient muscles showed a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21).	Iron	6-10	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	93-99
25575693-8	2015	We conclude that in AD damage occurs in conjunction with iron accumulation, and the brain iron load associated with loss control of the brain iron metabolism related protein DMT1 and FPN1 expressions.	Iron	90-94	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	174-178
24119307-5	2014	Furthermore, the upregulation of the two low affinity sulfate transporter genes SlST2.1 and SlST4.1 in iron-deficient roots, accompanied by a substantial accumulation of total sulfur and thiols in shoots of iron-starved plants, likely supports an increased root-to-shoot translocation of sulfate.	Iron	103-107	sulfate transporter 2.1-like	Solanum lycopersicum	80-87
24119307-5	2014	Furthermore, the upregulation of the two low affinity sulfate transporter genes SlST2.1 and SlST4.1 in iron-deficient roots, accompanied by a substantial accumulation of total sulfur and thiols in shoots of iron-starved plants, likely supports an increased root-to-shoot translocation of sulfate.	Iron	103-107	probable sulfate transporter 4.2-like	Solanum lycopersicum	92-99
25907956-4	2015	We evaluated the association of serum iron levels with B-type natriuretic peptide (BNP), cardiac troponin I (cTnI), and high-sensitivity C-reactive protein (hs-CRP) levels on admission, and analyzed the correlation of serum iron levels with in-hospital AHF, death, and duration of hospital stay.	Iron	38-42	natriuretic peptide B	Homo sapiens	55-81
24119307-5	2014	Furthermore, the upregulation of the two low affinity sulfate transporter genes SlST2.1 and SlST4.1 in iron-deficient roots, accompanied by a substantial accumulation of total sulfur and thiols in shoots of iron-starved plants, likely supports an increased root-to-shoot translocation of sulfate.	Iron	207-211	sulfate transporter 2.1-like	Solanum lycopersicum	80-87
24119307-5	2014	Furthermore, the upregulation of the two low affinity sulfate transporter genes SlST2.1 and SlST4.1 in iron-deficient roots, accompanied by a substantial accumulation of total sulfur and thiols in shoots of iron-starved plants, likely supports an increased root-to-shoot translocation of sulfate.	Iron	207-211	probable sulfate transporter 4.2-like	Solanum lycopersicum	92-99
24174621-0	2014	Role of the menkes ATPase in the absorption of both copper and iron.	Iron	63-67	dynein axonemal heavy chain 8	Homo sapiens	19-25
25746420-7	2015	Furthermore, levels of glutamate receptors (both NMDA and AMPA) and nicotinic acetylcholine receptor (nAChR) were significantly elevated in the prefrontal cortex of iron-loaded rats (62% increase in NR1; 70% increase in Glu1A; 115% increase in nAChR).	Iron	165-169	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	199-202
25416390-7	2014	Ni- and Fe-containing CODHs are frequently associated with ACS, where the CODH component reduces CO2 to CO and ACS condenses CO with a methyl group and CoA to acetyl-CoA.Our current state of knowledge on how the three enzymes catalyze these reactions will be summarized and the different strategies of CODHs to achieve the same task within different active site architectures compared.	Iron	8-10	acyl-CoA synthetase short chain family member 2	Homo sapiens	59-62
25416390-7	2014	Ni- and Fe-containing CODHs are frequently associated with ACS, where the CODH component reduces CO2 to CO and ACS condenses CO with a methyl group and CoA to acetyl-CoA.Our current state of knowledge on how the three enzymes catalyze these reactions will be summarized and the different strategies of CODHs to achieve the same task within different active site architectures compared.	Iron	8-10	acyl-CoA synthetase short chain family member 2	Homo sapiens	111-114
25624148-8	2015	Meristem size is also decreased in response to Fe excess in ferritin mutant plants, implicating cell cycle arrest mediated by the ROS-activated SMR5/SMR7 cyclin-dependent kinase inhibitors pathway in the interaction between Fe and RSA.	Iron	47-49	hypothetical protein	Arabidopsis thaliana	144-148
24359955-1	2014	The transferrin receptor (TfR) is responsible for iron uptake through its trafficking between the plasma membrane and recycling endosomes, and as a result it has become a well-known marker for recycling endosomes.	Iron	50-54	transferrin receptor	Mus musculus	4-24
24359955-1	2014	The transferrin receptor (TfR) is responsible for iron uptake through its trafficking between the plasma membrane and recycling endosomes, and as a result it has become a well-known marker for recycling endosomes.	Iron	50-54	transferrin receptor	Mus musculus	26-29
24498631-5	2014	We describe the first disease in man likely caused by deficiency in NFS1, a cysteine desulfurase that is implicated in respiratory chain function and iron maintenance by initiating Fe-S cluster biosynthesis.	Iron	150-154	NFS1 cysteine desulfurase	Homo sapiens	68-72
25624148-8	2015	Meristem size is also decreased in response to Fe excess in ferritin mutant plants, implicating cell cycle arrest mediated by the ROS-activated SMR5/SMR7 cyclin-dependent kinase inhibitors pathway in the interaction between Fe and RSA.	Iron	224-226	hypothetical protein	Arabidopsis thaliana	144-148
24498631-5	2014	We describe the first disease in man likely caused by deficiency in NFS1, a cysteine desulfurase that is implicated in respiratory chain function and iron maintenance by initiating Fe-S cluster biosynthesis.	Iron	181-185	NFS1 cysteine desulfurase	Homo sapiens	68-72
25794933-6	2015	Further investigation showed that bHLH104 interacted with another IVc subgroup bHLH protein, IAA-LEUCINE RESISTANT3 (ILR3), which also plays an important role in Fe homeostasis.	Iron	162-164	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	93-115
24117441-0	2014	AtSIA1 AND AtOSA1: two Abc1 proteins involved in oxidative stress responses and iron distribution within chloroplasts.	Iron	80-84	Protein kinase superfamily protein	Arabidopsis thaliana	0-6
25794933-6	2015	Further investigation showed that bHLH104 interacted with another IVc subgroup bHLH protein, IAA-LEUCINE RESISTANT3 (ILR3), which also plays an important role in Fe homeostasis.	Iron	162-164	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	117-121
25825542-2	2015	Recently, using systematic time studies of neuroblastoma cell growth, we better defined the G1 arrest caused by iron chelation to a point in mid-G1, where cyclin E protein is present, but the cyclin E/CDK2 complex kinase activity is inhibited.	Iron	112-116	cyclin dependent kinase 2	Homo sapiens	201-205
24117441-4	2014	The comparison of atsia1 and atosa1 mutants, atsia1/atosa1 double mutant and wild-type plants revealed a reduction in plastidial iron-containing proteins of the Cytb6 f complex in the mutants.	Iron	129-133	Protein kinase superfamily protein	Arabidopsis thaliana	18-58
24117441-5	2014	Iron uptake from soil is not hampered in mutant lines, suggesting that AtSIA1 and AtOSA1 affect iron distribution within the chloroplast.	Iron	0-4	Protein kinase superfamily protein	Arabidopsis thaliana	71-77
25533527-2	2015	Alterations of these processes are present in a number of human pathologies; among them, in Friedreich"s ataxia, in which a deficiency of functional frataxin, an iron-binding protein, leads to progressive neuromuscular degenerative disease.	Iron	162-166	frataxin	Homo sapiens	149-157
24117441-5	2014	Iron uptake from soil is not hampered in mutant lines, suggesting that AtSIA1 and AtOSA1 affect iron distribution within the chloroplast.	Iron	96-100	Protein kinase superfamily protein	Arabidopsis thaliana	71-77
24262171-5	2014	In the in vitro model, lactacystin causes a marked increase in labile iron, reactive oxygen species, alteration of iron regulatory protein (IRP)/iron response element expression levels, and an increase in the aggregation of ubiquitin-conjugated proteins prior to cell injury and death.	Iron	115-119	Wnt family member 2	Homo sapiens	140-143
25533527-3	2015	The putative iron-binding motif of acidic residues EExxED was selected from the first alpha-helical stretch of the frataxin protein family and grafted onto a foreign peptide scaffold corresponding to the C-terminal alpha-helix from E. coli thioredoxin.	Iron	13-17	frataxin	Homo sapiens	115-123
25533527-5	2015	Although isolated GRAP lacks a stable secondary structure in solution, when iron is added, the peptide acquires an alpha-helical structure.	Iron	76-80	GRB2 related adaptor protein	Homo sapiens	18-22
25533527-10	2015	Altogether, these results contribute to an understanding of the iron-binding mechanisms in proteins and, in particular, in the case of human frataxin.	Iron	64-68	frataxin	Homo sapiens	141-149
25476789-6	2015	The potential HERC2 interactors included the eukaryotic translation initiation factor 3 complex, the intracellular transport COPI coatomer complex, the glycogen regulator phosphorylase kinase, beta-catenin, PI3 kinase, and proteins involved in fatty acid transport and iron homeostasis.	Iron	269-273	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	14-19
24989467-11	2014	On the other hand, Fe alone reduced Mtap2, Th and Olig2 expression levels, and increased Emx2.	Iron	19-21	oligodendrocyte transcription factor 2	Homo sapiens	50-55
25504993-7	2015	The data suggest iron dysregulation associated with HFE allelic variants may play an important role in increasing susceptibility to environmental exposures, leading to recurring injury and fibrosis in IPF.	Iron	17-21	homeostatic iron regulator	Homo sapiens	52-55
23999124-6	2013	Two Rhes mutants - the phosphomimetic form (serine 239 to aspartic acid) and constitutively active form (alanine 173 to valine) - displayed an increase in iron uptake compared to the wild-type Rhes.	Iron	155-159	RASD family member 2	Homo sapiens	4-8
23999124-6	2013	Two Rhes mutants - the phosphomimetic form (serine 239 to aspartic acid) and constitutively active form (alanine 173 to valine) - displayed an increase in iron uptake compared to the wild-type Rhes.	Iron	155-159	RASD family member 2	Homo sapiens	193-197
23999124-7	2013	These findings suggest that Rhes may play a crucial role in striatal iron homeostasis.	Iron	69-73	RASD family member 2	Homo sapiens	28-32
24100161-1	2013	Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia.	Iron	48-52	frataxin	Homo sapiens	0-8
24100161-10	2013	From these results we can conclude that, in addition to altering iron homeostasis, frataxin depletion involves drastic metabolic remodeling governed by Adr1 and Cth2 that finally leads to downregulation of iron-sulfur proteins and other proteins involved in respiratory metabolism.	Iron	65-69	frataxin	Homo sapiens	83-91
24100161-10	2013	From these results we can conclude that, in addition to altering iron homeostasis, frataxin depletion involves drastic metabolic remodeling governed by Adr1 and Cth2 that finally leads to downregulation of iron-sulfur proteins and other proteins involved in respiratory metabolism.	Iron	206-210	frataxin	Homo sapiens	83-91
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	Fit2p	Saccharomyces cerevisiae S288C	254-258
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	siderophore transporter	Saccharomyces cerevisiae S288C	260-264
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	ferroxidase FET3	Saccharomyces cerevisiae S288C	266-270
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	medium-chain fatty acid-CoA ligase FAA2	Saccharomyces cerevisiae S288C	340-344
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	acyl-CoA oxidase	Saccharomyces cerevisiae S288C	346-350
24126888-5	2013	Iron overload also led to induction of unfolded protein response (XBP1 splicing, activation of IRE-1alpha and PERK, as well as sequestration of GRP78) and ER stress (increased CHOP protein expression) following HFD and ethanol.	Iron	0-4	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	95-105
24284114-8	2013	CONCLUSIONS: Experimentation with human squamous epithelial carcinoma cells has indicated that the iron chelator CP94 significantly increased PpIX accumulation induced by each PpIX congener investigated (ALA/MAL/HAL) at all oxygen concentrations employed (5%/20%/40%) resulting in increased levels of photobleaching and reduced cell viability on irradiation.	Iron	99-103	beaded filament structural protein 1	Homo sapiens	113-117
24284114-10	2013	It is therefore concluded that iron chelation with CP94 is a simple protocol modification with which it may be much easier to enhance clinical PDT efficacy than the complex and less well understood process of oxygen manipulation.	Iron	31-35	beaded filament structural protein 1	Homo sapiens	51-55
29147365-8	2013	It demonstrated the importance of early detection and initiation of treatment of iron overload in preventing HCC in MDS patients, even among Asian population.	Iron	81-85	HCC	Homo sapiens	109-112
25049750-3	2013	The optimal pH for the phosvitin extraction from yolk granules was determined, and the iron-binding ability of the extracted phosvitin (final product) was tested.	Iron	87-91	casein kinase 2 beta	Homo sapiens	125-134
23994517-6	2013	The greatest increase in muscle iron content occurred during the period of animal growth and was associated with downregulation of TfR1 and IRP2 expression.	Iron	32-36	transferrin receptor	Rattus norvegicus	131-135
24074816-1	2013	The pH impact on reductive dechlorination of cis-dichloroethylene (cis-DCE) was investigated using in situ Fe precipitates formed under iron-rich sulfate-reducing conditions.	Iron	107-109	24-dehydrocholesterol reductase	Homo sapiens	71-74
24074816-1	2013	The pH impact on reductive dechlorination of cis-dichloroethylene (cis-DCE) was investigated using in situ Fe precipitates formed under iron-rich sulfate-reducing conditions.	Iron	136-140	24-dehydrocholesterol reductase	Homo sapiens	71-74
24074816-2	2013	The dechlorination rate of cis-DCE increased with pH, which was attributed to changes in the solid-phase Fe concentration, the composition of Fe minerals, and the surface speciation of Fe minerals.	Iron	105-107	24-dehydrocholesterol reductase	Homo sapiens	31-34
24074816-2	2013	The dechlorination rate of cis-DCE increased with pH, which was attributed to changes in the solid-phase Fe concentration, the composition of Fe minerals, and the surface speciation of Fe minerals.	Iron	142-144	24-dehydrocholesterol reductase	Homo sapiens	31-34
24074816-2	2013	The dechlorination rate of cis-DCE increased with pH, which was attributed to changes in the solid-phase Fe concentration, the composition of Fe minerals, and the surface speciation of Fe minerals.	Iron	142-144	24-dehydrocholesterol reductase	Homo sapiens	31-34
24074816-7	2013	Based on a proposed model of the surface acidity of Fe minerals, the increasing deprotonated surface Fe(II) groups with pH correlated well with the enhanced cis-DCE dechlorination.	Iron	52-54	24-dehydrocholesterol reductase	Homo sapiens	161-164
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Iron	221-225	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	70-90
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Iron	221-225	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	92-95
23406462-5	2013	Cytoplasmic CD71 expression was largely negative in angiomatous meningioma cases, but positive in meningothelial and high-grade meningiomas, suggesting that the transferrin-dependent iron transporter was involved in iron uptake in meningiomas.	Iron	183-187	transferrin receptor	Homo sapiens	12-16
23806658-0	2013	Nucleotide-specific recognition of iron-responsive elements by iron regulatory protein 1.	Iron	35-39	aconitase 1	Homo sapiens	63-88
23806658-2	2013	In one mode of operation, IRP1 binds iron-responsive element (IRE) stem-loops in messenger RNAs encoding proteins of iron metabolism to control their rate of translation.	Iron	37-41	aconitase 1	Homo sapiens	26-30
23806658-2	2013	In one mode of operation, IRP1 binds iron-responsive element (IRE) stem-loops in messenger RNAs encoding proteins of iron metabolism to control their rate of translation.	Iron	117-121	aconitase 1	Homo sapiens	26-30
23806658-3	2013	In its other mode, IRP1 serves as cytoplasmic aconitase to correlate iron availability with the energy and oxidative stress status of the cell.	Iron	69-73	aconitase 1	Homo sapiens	19-23
24036531-4	2013	Hereditary hemochromatosis is a genetic disorder with mutations in the HFE gene, characterized by iron overload (with a reduced vitamin C stability) and with a predominance of affected men.	Iron	98-102	homeostatic iron regulator	Homo sapiens	71-74
23909240-0	2013	His86 from the N-terminus of frataxin coordinates iron and is required for Fe-S cluster synthesis.	Iron	50-54	frataxin	Homo sapiens	29-37
23909240-0	2013	His86 from the N-terminus of frataxin coordinates iron and is required for Fe-S cluster synthesis.	Iron	75-79	frataxin	Homo sapiens	29-37
23909240-1	2013	Human frataxin has a vital role in the biosynthesis of iron-sulfur (Fe-S) clusters in mitochondria, and its deficiency causes the neurodegenerative disease Friedreich"s ataxia.	Iron	68-72	frataxin	Homo sapiens	6-14
23909240-2	2013	Proposed functions for frataxin in the Fe-S pathway include iron donation to the Fe-S cluster machinery and regulation of cysteine desulfurase activity to control the rate of Fe-S production, although further molecular detail is required to distinguish these two possibilities.	Iron	39-43	frataxin	Homo sapiens	23-31
23909240-2	2013	Proposed functions for frataxin in the Fe-S pathway include iron donation to the Fe-S cluster machinery and regulation of cysteine desulfurase activity to control the rate of Fe-S production, although further molecular detail is required to distinguish these two possibilities.	Iron	60-64	frataxin	Homo sapiens	23-31
23909240-2	2013	Proposed functions for frataxin in the Fe-S pathway include iron donation to the Fe-S cluster machinery and regulation of cysteine desulfurase activity to control the rate of Fe-S production, although further molecular detail is required to distinguish these two possibilities.	Iron	81-85	frataxin	Homo sapiens	23-31
23909240-2	2013	Proposed functions for frataxin in the Fe-S pathway include iron donation to the Fe-S cluster machinery and regulation of cysteine desulfurase activity to control the rate of Fe-S production, although further molecular detail is required to distinguish these two possibilities.	Iron	81-85	frataxin	Homo sapiens	23-31
23909240-3	2013	It is well established that frataxin can coordinate iron using glutamate and aspartate side chains on the protein surface; however, in this work we identify a new iron coordinating residue in the N-terminus of human frataxin using complementary spectroscopic and structural approaches.	Iron	52-56	frataxin	Homo sapiens	28-36
23909240-3	2013	It is well established that frataxin can coordinate iron using glutamate and aspartate side chains on the protein surface; however, in this work we identify a new iron coordinating residue in the N-terminus of human frataxin using complementary spectroscopic and structural approaches.	Iron	52-56	frataxin	Homo sapiens	216-224
23909240-3	2013	It is well established that frataxin can coordinate iron using glutamate and aspartate side chains on the protein surface; however, in this work we identify a new iron coordinating residue in the N-terminus of human frataxin using complementary spectroscopic and structural approaches.	Iron	163-167	frataxin	Homo sapiens	28-36
23909240-3	2013	It is well established that frataxin can coordinate iron using glutamate and aspartate side chains on the protein surface; however, in this work we identify a new iron coordinating residue in the N-terminus of human frataxin using complementary spectroscopic and structural approaches.	Iron	163-167	frataxin	Homo sapiens	216-224
23909240-5	2013	If a binding site that includes His86 is important for Fe-S cluster synthesis as part of its chaperone function, this raises the possibility that either iron binding at the acidic surface of frataxin may be spurious or that it is required for protein-protein interactions with the Fe-S biosynthetic quaternary complex.	Iron	55-59	frataxin	Homo sapiens	191-199
23909240-5	2013	If a binding site that includes His86 is important for Fe-S cluster synthesis as part of its chaperone function, this raises the possibility that either iron binding at the acidic surface of frataxin may be spurious or that it is required for protein-protein interactions with the Fe-S biosynthetic quaternary complex.	Iron	153-157	frataxin	Homo sapiens	191-199
23909240-5	2013	If a binding site that includes His86 is important for Fe-S cluster synthesis as part of its chaperone function, this raises the possibility that either iron binding at the acidic surface of frataxin may be spurious or that it is required for protein-protein interactions with the Fe-S biosynthetic quaternary complex.	Iron	281-285	frataxin	Homo sapiens	191-199
23909240-6	2013	Our data suggest that iron coordination to frataxin may be significant to the Fe-S cluster biosynthesis pathway in mitochondria.	Iron	22-26	frataxin	Homo sapiens	43-51
23909240-6	2013	Our data suggest that iron coordination to frataxin may be significant to the Fe-S cluster biosynthesis pathway in mitochondria.	Iron	78-82	frataxin	Homo sapiens	43-51
31986714-1	2013	The FeIII azide complexes [FeIII (N3 )cyclam-ac]PF6 (1 PF6 ), [FeIII (N3 )Me3 cyclam-ac]PF6 (2 PF6 ), and trans-[FeIII (N3 )2 cyclam]ClO4 (3 ClO4 ) (cyclam=1,4,8,11-tetraazacyclotetradecane; cyclam-ac=1,4,8,11-tetraazacyclotetradecane-1-acetate; Me3 cyclam-ac=4,8,11-trimethyl-1,4,8,11-tetraazacyclotetra-decane-1-acetate) are studied in the gas phase with special emphasis on the formation of high-valent iron nitrides by collision-induced dissociation.	Iron	4-9	sperm associated antigen 17	Homo sapiens	48-51
23794717-0	2013	Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.	Iron	56-60	homeostatic iron regulator	Homo sapiens	35-38
23794717-1	2013	BACKGROUND: Genome-wide association studies have convincingly shown that single nucleotide polymorphisms (SNPs) in HFE and TMPRSS6 are associated with iron parameters.	Iron	151-155	homeostatic iron regulator	Homo sapiens	115-118
23794717-4	2013	We report here the second study to investigate the role of hepcidin in the associations between common variants in HFE and TMPRSS6 with iron parameters.	Iron	136-140	homeostatic iron regulator	Homo sapiens	115-118
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	130-134	homeostatic iron regulator	Homo sapiens	23-26
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	130-134	homeostatic iron regulator	Homo sapiens	87-90
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	180-184	homeostatic iron regulator	Homo sapiens	23-26
23664582-8	2013	Moreover, introduction of HvHMA2 into tobacco interfered with Fe metabolism and Fe accumulation was modified in HvHMA2-transformants in a Zn- and Cd-concentration dependent manner.	Iron	62-64	HMA2	Hordeum vulgare	26-32
23664582-8	2013	Moreover, introduction of HvHMA2 into tobacco interfered with Fe metabolism and Fe accumulation was modified in HvHMA2-transformants in a Zn- and Cd-concentration dependent manner.	Iron	80-82	HMA2	Hordeum vulgare	26-32
23664582-8	2013	Moreover, introduction of HvHMA2 into tobacco interfered with Fe metabolism and Fe accumulation was modified in HvHMA2-transformants in a Zn- and Cd-concentration dependent manner.	Iron	80-82	HMA2	Hordeum vulgare	112-118
23922777-2	2013	We have previously shown that mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficient-high hepcidin Tmprss6 KO mice.	Iron	40-44	transmembrane serine protease 6	Mus musculus	163-170
23922777-9	2013	Liver expression profiling of Hfe(-/-) deficient versus iron loaded mice show the opposite expression of some of the genes modulated by the loss of Tmprss6.	Iron	56-60	transmembrane serine protease 6	Mus musculus	148-155
23590984-3	2013	Iron regulatory protein 1 (IRP1) is a bi-functional protein that can act either as a post-transcriptional regulator of mRNAs containing iron responsive elements, or as a [4Fe-4S] cluster-containing cytosolic aconitase.	Iron	136-140	aconitase 1	Homo sapiens	0-25
23590984-3	2013	Iron regulatory protein 1 (IRP1) is a bi-functional protein that can act either as a post-transcriptional regulator of mRNAs containing iron responsive elements, or as a [4Fe-4S] cluster-containing cytosolic aconitase.	Iron	136-140	aconitase 1	Homo sapiens	27-31
23590984-4	2013	Previous X-ray crystallography results show that IRP1 is in an open L-shape conformation when bound to IRE-RNAs, and in a globular conformation when it binds an iron-sulfur cluster.	Iron	161-165	aconitase 1	Homo sapiens	49-53
23853349-2	2013	Some iron-overload diseases as HFE-associated hemochromatosis and beta-thalassemia are quite common, whereas others are very rare.	Iron	5-9	homeostatic iron regulator	Homo sapiens	31-34
23874600-0	2013	Inhibition of beta2-microglobulin/hemochromatosis enhances radiation sensitivity by induction of iron overload in prostate cancer cells.	Iron	97-101	beta-2 microglobulin	Mus musculus	14-33
23874600-7	2013	Inhibition of beta2-M or HFE sensitized prostate cancer cells to radiation by increasing iron and reactive oxygen species and decreasing DNA repair and stress response proteins.	Iron	89-93	beta-2 microglobulin	Mus musculus	14-21
23874600-14	2013	Additionally, inhibition of beta2-M sensitizes cancer cells to clinically used therapies such as radiation by inducing iron overload and decreasing DNA repair enzymes.	Iron	119-123	beta-2 microglobulin	Mus musculus	28-35
23862168-0	2013	HFE mutations in Caucasian participants of the Hemochromatosis and Iron Overload Screening study with serum ferritin level &lt;1000 microg/L.	Iron	67-71	homeostatic iron regulator	Homo sapiens	0-3
23862168-3	2013	METHODS: The Hemochromatosis and Iron Overload Screening study screened 99,711 participants for serum ferritin levels, transferrin saturation and genetic testing for the C282Y and H63D mutations of the HFE gene.	Iron	33-37	homeostatic iron regulator	Homo sapiens	202-205
24028003-1	2013	Due to the surface reaction between zero-valent iron and Cr(VI), iron cannot be fully utilized in the Fe(0)-Permeable Reactive Barrier(PRB), and the PRB is prone to compaction and blockage.	Iron	48-52	RB transcriptional corepressor 1	Homo sapiens	149-152
24028003-1	2013	Due to the surface reaction between zero-valent iron and Cr(VI), iron cannot be fully utilized in the Fe(0)-Permeable Reactive Barrier(PRB), and the PRB is prone to compaction and blockage.	Iron	65-69	RB transcriptional corepressor 1	Homo sapiens	135-138
24028003-1	2013	Due to the surface reaction between zero-valent iron and Cr(VI), iron cannot be fully utilized in the Fe(0)-Permeable Reactive Barrier(PRB), and the PRB is prone to compaction and blockage.	Iron	102-107	RB transcriptional corepressor 1	Homo sapiens	135-138
23606622-3	2013	However, recent research reveals a number of novel functions of ferritin besides iron storage; for example, a ferritin receptor, transferrin receptor 1 (TfR1), has been identified and serum ferritin levels are found to be elevated in tumors.	Iron	81-85	transferrin receptor	Homo sapiens	129-151
23606622-3	2013	However, recent research reveals a number of novel functions of ferritin besides iron storage; for example, a ferritin receptor, transferrin receptor 1 (TfR1), has been identified and serum ferritin levels are found to be elevated in tumors.	Iron	81-85	transferrin receptor	Homo sapiens	153-157
24024382-7	2013	CONCLUSION: The nutritional status of the iron may be affected by copper deficiency through influencing the absorption, the results indicate that copper deficiency influences iron homeostasis in cells through affecting the expression of IRP2 and the activity of IRP-RNA combination which change the expressions of ferritin and transferrin mRNA.	Iron	42-46	caspase 3	Rattus norvegicus	237-240
24024382-7	2013	CONCLUSION: The nutritional status of the iron may be affected by copper deficiency through influencing the absorption, the results indicate that copper deficiency influences iron homeostasis in cells through affecting the expression of IRP2 and the activity of IRP-RNA combination which change the expressions of ferritin and transferrin mRNA.	Iron	175-179	caspase 3	Rattus norvegicus	237-240
23754414-2	2013	As part of a project initially directed at understanding how HCV may disrupt cellular iron homeostasis, we found that HCV alters expression of the iron uptake receptor transferrin receptor 1 (TfR1).	Iron	86-90	transferrin receptor	Homo sapiens	192-196
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	20-24	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	250-254
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	215-219	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	250-254
23512844-2	2013	Hereditary hemochromatosis, a common condition caused by HFE gene mutations, can lead to excess iron storage and disease but clinical penetrance of HFE gene mutations is low and many people with elevated iron stores lack HFE mutations.	Iron	96-100	homeostatic iron regulator	Homo sapiens	57-60
23300183-7	2013	Mapping and sequencing in an anemic mouse termed hem8 identified an I286F substitution in Tmprss6, a serine protease essential for iron metabolism; this substitution impaired in vitro protease activity.	Iron	131-135	transmembrane serine protease 6	Mus musculus	90-97
23390091-0	2013	Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.	Iron	45-49	furin, paired basic amino acid cleaving enzyme	Homo sapiens	126-131
23390091-12	2013	Our results support the notion that, when iron is limiting, hTfR1 levels increase at least in part by way of the down-regulation of PC7 expression.	Iron	42-46	transferrin receptor	Homo sapiens	60-65
23552122-13	2013	Moreover, iron restriction markedly attenuated renal expression of nuclear mineralocorticoid receptor and Rac1 activity in CKD rats.	Iron	10-14	Rac family small GTPase 1	Rattus norvegicus	106-110
23705020-3	2013	Loss of HFE function is known to alter the intestinal expression of DMT1 (divalent metal transporter-1) and Fpn (ferroportin), transporters that have been implicated in absorption of both iron and manganese.	Iron	188-192	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	68-72
23705020-3	2013	Loss of HFE function is known to alter the intestinal expression of DMT1 (divalent metal transporter-1) and Fpn (ferroportin), transporters that have been implicated in absorption of both iron and manganese.	Iron	188-192	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	74-102
23425894-0	2013	Health implications of PAH release from coated cast iron drinking water distribution systems in The Netherlands.	Iron	52-56	phenylalanine hydroxylase	Homo sapiens	23-26
23570308-2	2013	The synthesis of the starting complex is accomplished by reaction of the electron-rich Fe(0) precursor [(dmpe)2Fe(PMe3)] 1 (dmpe =1,2-bis(dimethylphosphino)ethane) with the N-heterocyclic chlorosilylene LSiCl (L = PhC(N(t)Bu)2) 2 to give, via Me3P elimination, the corresponding iron complex [(dmpe)2Fe( :Si(Cl)L)] 3.	Iron	87-92	adhesion G protein-coupled receptor L3	Homo sapiens	308-316
23570308-9	2013	The reaction pathway presumably involves a ketone-assisted 1,2-hydride transfer from the Si(II) to Fe(0) center, as a key elementary step, resulting in a betaine-like silyliumylidene intermediate.	Iron	99-104	elongin A	Homo sapiens	89-95
24218836-4	2013	Nitrogen adsorption analyses showed that the BET specific surface area and total pore volume increased with iron impregnation.	Iron	108-112	delta/notch like EGF repeat containing	Homo sapiens	45-48
22968581-3	2013	Well characterized examples are that of transferrin receptor (TfR) and intercellular adhesion molecule 1 (ICAM-1), involved in iron transport and leukocyte extravasation, respectively.	Iron	127-131	transferrin receptor	Mus musculus	40-60
22968581-3	2013	Well characterized examples are that of transferrin receptor (TfR) and intercellular adhesion molecule 1 (ICAM-1), involved in iron transport and leukocyte extravasation, respectively.	Iron	127-131	transferrin receptor	Mus musculus	62-65
22968581-3	2013	Well characterized examples are that of transferrin receptor (TfR) and intercellular adhesion molecule 1 (ICAM-1), involved in iron transport and leukocyte extravasation, respectively.	Iron	127-131	intercellular adhesion molecule 1	Mus musculus	71-104
22968581-3	2013	Well characterized examples are that of transferrin receptor (TfR) and intercellular adhesion molecule 1 (ICAM-1), involved in iron transport and leukocyte extravasation, respectively.	Iron	127-131	intercellular adhesion molecule 1	Mus musculus	106-112
23455022-3	2013	In Arabidopsis, mutations in RNA polymerase II CTD-phosphatase-like 1 (CPL1) enhance the expression of Fe utilization-related genes including FIT under Fe deficiency.	Iron	103-105	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	71-75
23455022-4	2013	Fe content is significantly increased in the roots and decreased in the shoots of cpl1-2 plants, and root growth of the cpl1-2 mutant shows higher tolerance to Fe deficiency and to toxicity of cadmium (Cd).	Iron	0-2	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	82-86
23270517-10	2013	Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs.	Iron	92-96	transferrin receptor	Mus musculus	14-34
23270517-10	2013	Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs.	Iron	92-96	transferrin receptor	Mus musculus	36-40
23270517-10	2013	Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs.	Iron	111-115	transferrin receptor	Mus musculus	14-34
23270517-10	2013	Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs.	Iron	111-115	transferrin receptor	Mus musculus	36-40
23688756-1	2013	OBJECTIVE: To investigate the mechanisms underlying bone marrow damage by iron overload in pancytopenic patients with positive BMMNC-Coombs test (IRP).	Iron	74-78	Wnt family member 2	Homo sapiens	146-149
23688756-4	2013	Antioxidants were added to iron overloading IRP BMMNC, and then the changes of indices above were detected by FCM.	Iron	27-31	Wnt family member 2	Homo sapiens	44-47
23688756-6	2013	RESULTS: ROS and apoptosis of BMMNC, myelocytes, erythrocytes and stem cells of iron overloading IRP patients were significantly higher than that of non-iron overloading IRP ones and normal controls (P &lt; 0.05).	Iron	80-84	Wnt family member 2	Homo sapiens	97-100
23688756-6	2013	RESULTS: ROS and apoptosis of BMMNC, myelocytes, erythrocytes and stem cells of iron overloading IRP patients were significantly higher than that of non-iron overloading IRP ones and normal controls (P &lt; 0.05).	Iron	153-157	Wnt family member 2	Homo sapiens	97-100
23688756-7	2013	The expressions of Bcl-2 on BMMNC, erythrocytes and stem cells of iron overloading IRP patients were significantly lower than those of non-iron overloading IRP ones (P &lt; 0.05).	Iron	66-70	Wnt family member 2	Homo sapiens	83-86
23688756-8	2013	The levels of Caspase-3 on myelocytes, erythrocytes and stem cells of iron overloading IRP patients were significantly higher than those of non-iron overloading IRP ones and normal controls (P &lt; 0.05).	Iron	70-74	Wnt family member 2	Homo sapiens	87-90
23688756-9	2013	After treatment with antioxidants, the expressions of ROS, Caspase-3 and apoptosis of iron overloading IRP BMMNC significantly decreased, but opposite for Bcl-2.	Iron	86-90	Wnt family member 2	Homo sapiens	103-106
23734982-0	2013	The role of Arabidopsis thaliana NAR1, a cytosolic iron-sulfur cluster assembly component, in gametophytic gene expression and oxidative stress responses in vegetative tissue.	Iron	51-55	ferredoxin hydrogenase	Arabidopsis thaliana	33-37
23734982-8	2013	Transcriptome analysis of homozygous viable nar1-4 seedlings showed transcriptional repression of a subset of genes involved in "iron ion transport" and "response to nitrate".	Iron	129-133	ferredoxin hydrogenase	Arabidopsis thaliana	44-48
23791636-10	2013	In the presence of ATK (cPLA2 inhibitor) and YM 26734 (sPLA2 inhibitor), the nuclear localization of both p65 and p50 NF-kappaB subunits was restored to control levels in retinas exposed to iron-induced oxidative stress.	Iron	190-194	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-109
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	109-113	transferrin receptor	Homo sapiens	123-145
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	109-113	transferrin receptor	Homo sapiens	147-151
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	109-113	transferrin receptor	Homo sapiens	123-145
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	109-113	transferrin receptor	Homo sapiens	147-151
23508576-1	2013	UNLABELLED: Divalent metal-ion transporter-1 (DMT1) is required for iron uptake by the intestine and developing erythroid cells.	Iron	68-72	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	46-50
23508576-2	2013	DMT1 is also present in the liver, where it has been implicated in the uptake of transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload.	Iron	99-103	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
23508576-2	2013	DMT1 is also present in the liver, where it has been implicated in the uptake of transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload.	Iron	136-140	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
23508576-2	2013	DMT1 is also present in the liver, where it has been implicated in the uptake of transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload.	Iron	136-140	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
23859349-3	2013	The detailed mechanism of iron regulation of frataxin expression is yet unknown.	Iron	26-30	frataxin	Homo sapiens	45-53
23447398-1	2013	Treatment of [Cp*(dppe)Fe-C C-TTFMe3] (1) with Ag[PF6] (3 equiv) in DMF provides the binuclear complex [Cp*(dppe)Fe=C=C=TTFMe2 =CH-CH=TTFMe2 =C=C=Fe(dppe)Cp*][PF6]2 (2[PF6 ]2) isolated as a deep-blue powder in 69 % yield.	Iron	23-25	sperm associated antigen 17	Homo sapiens	50-53
23447398-1	2013	Treatment of [Cp*(dppe)Fe-C C-TTFMe3] (1) with Ag[PF6] (3 equiv) in DMF provides the binuclear complex [Cp*(dppe)Fe=C=C=TTFMe2 =CH-CH=TTFMe2 =C=C=Fe(dppe)Cp*][PF6]2 (2[PF6 ]2) isolated as a deep-blue powder in 69 % yield.	Iron	23-25	sperm associated antigen 17	Homo sapiens	159-162
23447398-1	2013	Treatment of [Cp*(dppe)Fe-C C-TTFMe3] (1) with Ag[PF6] (3 equiv) in DMF provides the binuclear complex [Cp*(dppe)Fe=C=C=TTFMe2 =CH-CH=TTFMe2 =C=C=Fe(dppe)Cp*][PF6]2 (2[PF6 ]2) isolated as a deep-blue powder in 69 % yield.	Iron	23-25	sperm associated antigen 17	Homo sapiens	159-162
23447398-13	2013	In 2[PF6], the charge and the spin are both symmetrically distributed on the carbon bridge and only moderately on the iron and TTFMe2 electroactive centers.	Iron	118-122	sperm associated antigen 17	Homo sapiens	5-8
23723143-0	2013	Adiponectin ameliorates iron-overload cardiomyopathy through the PPARalpha-PGC-1-dependent signaling pathway.	Iron	24-28	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	75-80
25500022-10	2015	RESULT(S): Iron overload increased p65:DNA-binding activity and decreased IkappaBalpha and p65 cytoplasmic expression in ESCs after 30 minutes of incubation as compared with the basal condition.	Iron	11-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	35-38
23723143-7	2013	In addition, AAV-ADIPOQ-treated iron-overload mice had lower expression of inflammatory markers, including myeloperoxidase activity, monocyte chemotactic protein-1, tumor necrosis factor-alpha, interleukin-6, and intercellular adhesion molecule-1, than iron-overloaded mice not treated with AAV-ADIPOQ.	Iron	32-36	intercellular adhesion molecule 1	Mus musculus	213-246
23903042-10	2013	The Rnt1 RNase III exonuclease protects cells from excess iron by promoting the degradation of a subset of the Fe acquisition system when iron levels rise.	Iron	58-62	ribonuclease III	Saccharomyces cerevisiae S288C	4-8
23903042-10	2013	The Rnt1 RNase III exonuclease protects cells from excess iron by promoting the degradation of a subset of the Fe acquisition system when iron levels rise.	Iron	111-113	ribonuclease III	Saccharomyces cerevisiae S288C	4-8
23903042-10	2013	The Rnt1 RNase III exonuclease protects cells from excess iron by promoting the degradation of a subset of the Fe acquisition system when iron levels rise.	Iron	138-142	ribonuclease III	Saccharomyces cerevisiae S288C	4-8
23608607-1	2013	BACKGROUND: MicroRNA-210 (miR-210) increases in hypoxia and regulates mitochondrial respiration through modulation of iron-sulfur cluster assembly proteins (ISCU1/2), a protein that is involved in Fe/S cluster synthesis.	Iron	118-122	microRNA 210	Rattus norvegicus	12-24
23608607-1	2013	BACKGROUND: MicroRNA-210 (miR-210) increases in hypoxia and regulates mitochondrial respiration through modulation of iron-sulfur cluster assembly proteins (ISCU1/2), a protein that is involved in Fe/S cluster synthesis.	Iron	118-122	microRNA 210	Rattus norvegicus	26-33
23608607-4	2013	Levels of miR-210 are significantly increased with iron chelation, however, this response was mediated entirely through the hypoxia-inducible factor (HIF) pathway.	Iron	51-55	microRNA 210	Rattus norvegicus	10-17
23457300-12	2013	Iron supplementation significantly decreased P(FIT2)-GFP expression and, surprisingly, restored P(TSA2)-GFP to wild-type levels.	Iron	0-4	Fit2p	Saccharomyces cerevisiae S288C	47-51
25500022-10	2015	RESULT(S): Iron overload increased p65:DNA-binding activity and decreased IkappaBalpha and p65 cytoplasmic expression in ESCs after 30 minutes of incubation as compared with the basal condition.	Iron	11-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	91-94
25500022-12	2015	TPCA-1 prevented the iron overload-induced increase of p65:DNA binding and IkappaBalpha degradation.	Iron	21-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	55-58
23935819-2	2013	This is via a classic release of repressor interaction of APP mRNA with iron-regulatory protein-1 (IRP1) whereas IRP2 controls the mRNAs encoding the L- and H-subunits of the iron storage protein, ferritin.	Iron	72-76	aconitase 1	Homo sapiens	99-103
25428993-4	2015	By contrast, peroxynitrite inhibited the mitochondrial manganese SOD1 (MSD1), peroxisomal copper/zinc SOD3 (CSD3), and chloroplastic iron SOD3 (FSD3), but no other SODs.	Iron	133-137	Fe superoxide dismutase 3	Arabidopsis thaliana	138-142
23898337-4	2013	This review focuses on the new actors discovered in the past few years, such as glutaredoxin, BOLA and NEET proteins as well as MIP18, MMS19, TAH18, DRE2 for the cytosolic machinery, which are integrated into a model for the plant Fe-S cluster biogenesis systems.	Iron	231-235	glutaredoxin	Homo sapiens	80-92
23593335-1	2013	In humans, the L-cysteine desulfurase NFS1 plays a crucial role in the mitochondrial iron-sulfur cluster biosynthesis and in the thiomodification of mitochondrial and cytosolic tRNAs.	Iron	85-89	NFS1 cysteine desulfurase	Homo sapiens	38-42
23350672-0	2013	Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states.	Iron	77-81	hemopexin	Homo sapiens	33-42
23506870-1	2013	This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron homeostasis.	Iron	84-88	solute carrier family 34 member 1	Homo sapiens	40-45
25306858-3	2015	Foremost, IRPs regulate ferritin H and ferritin L translation and thus iron storage, as well as transferrin receptor 1 (TfR1) mRNA stability, thereby adjusting receptor expression and iron uptake via receptor-mediated endocytosis of iron-loaded transferrin.	Iron	184-188	transferrin receptor	Homo sapiens	120-124
23894616-1	2013	Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation.	Iron	52-56	transferrin receptor	Rattus norvegicus	124-146
23894616-1	2013	Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation.	Iron	52-56	transferrin receptor	Rattus norvegicus	148-152
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	185-189	homeostatic iron regulator	Homo sapiens	309-312
25306858-3	2015	Foremost, IRPs regulate ferritin H and ferritin L translation and thus iron storage, as well as transferrin receptor 1 (TfR1) mRNA stability, thereby adjusting receptor expression and iron uptake via receptor-mediated endocytosis of iron-loaded transferrin.	Iron	184-188	transferrin receptor	Homo sapiens	120-124
25306858-8	2015	In bone marrow, erythroid heme biosynthesis is coordinated with iron availability through IRP-mediated translational control of erythroid 5-aminolevulinate synthase mRNA.	Iron	64-68	Wnt family member 2	Homo sapiens	90-93
23183585-1	2013	Highly proliferative cells have a dramatically increased need for iron which results in the expression of an increased number of transferrin receptors (TFR).	Iron	66-70	transferrin receptor	Homo sapiens	129-150
23183585-1	2013	Highly proliferative cells have a dramatically increased need for iron which results in the expression of an increased number of transferrin receptors (TFR).	Iron	66-70	transferrin receptor	Homo sapiens	152-155
25306858-9	2015	Moreover, the translational control of HIF2alpha mRNA in kidney by IRP1 coordinates erythropoietin synthesis with iron and oxygen supply.	Iron	114-118	aconitase 1	Homo sapiens	67-71
25597503-6	2015	These data raise important questions on the physiological mechanism of Fe-S cluster assembly and point to a unique function of frataxin as an enhancer of sulfur transfer within the NFS1-ISD11-ISCU complex.	Iron	71-75	frataxin	Homo sapiens	127-135
23317919-1	2013	Neutrophil gelatinase-associated lipocalin (NGAL/Lipocalin-2/Lcn-2) is a 25kDa protein which is involved in host defence against certain Gram negative bacteria upon binding of iron loaded bacterial siderophores thereby limiting the availability of this essential nutrient to bacteria resulting in inhibition of their growth and pathogenicity.	Iron	176-180	lipocalin 2	Mus musculus	61-66
23317919-9	2013	When investigating the underlying mechanisms we observed partly different expression of several iron metabolism genes between Lcn-2 +/+ and Lcn-2 -/- macrophages and most strikingly an increased formation of the anti-inflammatory cytokine IL-10 by Lcn-2 -/- macrophages.	Iron	96-100	lipocalin 2	Mus musculus	126-131
23317919-9	2013	When investigating the underlying mechanisms we observed partly different expression of several iron metabolism genes between Lcn-2 +/+ and Lcn-2 -/- macrophages and most strikingly an increased formation of the anti-inflammatory cytokine IL-10 by Lcn-2 -/- macrophages.	Iron	96-100	lipocalin 2	Mus musculus	140-145
23317919-9	2013	When investigating the underlying mechanisms we observed partly different expression of several iron metabolism genes between Lcn-2 +/+ and Lcn-2 -/- macrophages and most strikingly an increased formation of the anti-inflammatory cytokine IL-10 by Lcn-2 -/- macrophages.	Iron	96-100	lipocalin 2	Mus musculus	140-145
23317919-11	2013	Herein we provide first time evidence that Lcn-2 is involved in host defence against Chlamydia presumably by limiting the availability of iron to the pathogen.	Iron	138-142	lipocalin 2	Mus musculus	43-48
25277871-1	2015	BACKGROUND/AIMS: Innately low hepcidin levels lead to iron overload in HFE-associated hereditary haemochromatosis.	Iron	54-58	homeostatic iron regulator	Homo sapiens	71-74
23606747-1	2013	The transferrin receptor (TfR) mediates the uptake of transferrin (Tf)-bound iron from the plasma into the cells of peripheral tissues.	Iron	77-81	transferrin receptor	Homo sapiens	4-24
23606747-1	2013	The transferrin receptor (TfR) mediates the uptake of transferrin (Tf)-bound iron from the plasma into the cells of peripheral tissues.	Iron	77-81	transferrin receptor	Homo sapiens	26-29
23606747-3	2013	TfR expression is tightly controlled by the intracellular iron concentration through the regulation of TfR mRNA stability.	Iron	58-62	transferrin receptor	Homo sapiens	0-3
23606747-3	2013	TfR expression is tightly controlled by the intracellular iron concentration through the regulation of TfR mRNA stability.	Iron	58-62	transferrin receptor	Homo sapiens	103-106
23606747-5	2013	Previously, we reported a correlation between TfR ubiquitination and its iron-induced lysosomal degradation.	Iron	73-77	transferrin receptor	Homo sapiens	46-49
25706573-7	2015	Patients with an at-risk HFE genotype had significantly higher iron saturation, serum iron and hemoglobin (P&lt;0.001), without higher ferritin or liver enzyme levels.	Iron	63-67	homeostatic iron regulator	Homo sapiens	25-28
23606747-6	2013	The identification and characterization of a specific ubiquitin ligase for TfR is important in understanding the mechanism of iron homeostasis.	Iron	126-130	transferrin receptor	Homo sapiens	75-78
22917739-3	2013	The defining properties of frataxin - (i) the ability to bind iron, (ii) the ability to interact with, and donate iron to, other iron-binding proteins, and (iii) the ability to oligomerize, store iron and control iron redox chemistry - have been extensively characterized with different frataxin orthologs and their interacting protein partners.	Iron	62-66	frataxin	Homo sapiens	27-35
25706573-7	2015	Patients with an at-risk HFE genotype had significantly higher iron saturation, serum iron and hemoglobin (P&lt;0.001), without higher ferritin or liver enzyme levels.	Iron	86-90	homeostatic iron regulator	Homo sapiens	25-28
22917739-3	2013	The defining properties of frataxin - (i) the ability to bind iron, (ii) the ability to interact with, and donate iron to, other iron-binding proteins, and (iii) the ability to oligomerize, store iron and control iron redox chemistry - have been extensively characterized with different frataxin orthologs and their interacting protein partners.	Iron	114-118	frataxin	Homo sapiens	27-35
25300398-7	2015	In Bmp6-/- mice, iron challenge led to blunted activation of liver Smad signaling and hepcidin expression with a delay of 24 h, associated with increased Bmp5 and Bmp7 expression and increased Bmp2, 4, 5 and 9 expression in the duodenum.	Iron	17-21	bone morphogenetic protein 5	Mus musculus	154-158
22917739-3	2013	The defining properties of frataxin - (i) the ability to bind iron, (ii) the ability to interact with, and donate iron to, other iron-binding proteins, and (iii) the ability to oligomerize, store iron and control iron redox chemistry - have been extensively characterized with different frataxin orthologs and their interacting protein partners.	Iron	114-118	frataxin	Homo sapiens	27-35
22917739-3	2013	The defining properties of frataxin - (i) the ability to bind iron, (ii) the ability to interact with, and donate iron to, other iron-binding proteins, and (iii) the ability to oligomerize, store iron and control iron redox chemistry - have been extensively characterized with different frataxin orthologs and their interacting protein partners.	Iron	114-118	frataxin	Homo sapiens	27-35
22917739-3	2013	The defining properties of frataxin - (i) the ability to bind iron, (ii) the ability to interact with, and donate iron to, other iron-binding proteins, and (iii) the ability to oligomerize, store iron and control iron redox chemistry - have been extensively characterized with different frataxin orthologs and their interacting protein partners.	Iron	114-118	frataxin	Homo sapiens	27-35
22917739-4	2013	This very large body of biochemical and structural data [reviewed in (Bencze et al., 2006)] supports equally extensive biological evidence that frataxin is critical for mitochondrial iron metabolism and overall cellular iron homeostasis and antioxidant protection [reviewed in (Wilson, 2006)].	Iron	183-187	frataxin	Homo sapiens	144-152
22917739-4	2013	This very large body of biochemical and structural data [reviewed in (Bencze et al., 2006)] supports equally extensive biological evidence that frataxin is critical for mitochondrial iron metabolism and overall cellular iron homeostasis and antioxidant protection [reviewed in (Wilson, 2006)].	Iron	220-224	frataxin	Homo sapiens	144-152
22917739-7	2013	Finally, we discuss how defects in ISC synthesis could be a major (although likely not unique) contributor to the pathophysiology of FRDA via (i) loss of ISC-dependent enzymes, (ii) mitochondrial and cellular iron dysregulation, and (iii) enhanced iron-mediated oxidative stress.	Iron	209-213	frataxin	Homo sapiens	133-137
22917739-7	2013	Finally, we discuss how defects in ISC synthesis could be a major (although likely not unique) contributor to the pathophysiology of FRDA via (i) loss of ISC-dependent enzymes, (ii) mitochondrial and cellular iron dysregulation, and (iii) enhanced iron-mediated oxidative stress.	Iron	248-252	frataxin	Homo sapiens	133-137
25834305-0	2015	Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis.	Iron	19-23	sequestosome 1	Mus musculus	66-72
23620481-5	2013	Evidence has been provided that overexpression of AtHO1 could confer plant tolerance to iron deficiency by improving expression of AtFIT, AtFRO2 and AtIRT1, the activity of ferric-chelate reductase (FCR) and iron accumulation.	Iron	88-92	ferric reduction oxidase 2	Arabidopsis thaliana	138-144
23840800-2	2013	Some of the studies carried out on Western populations have shown a relationship between body iron status as determined by the ratio of concentrations of serum soluble transferrin receptor (sTfR) to ferritin and the risk of acute myocardial infarction (AMI).	Iron	94-98	transferrin receptor	Homo sapiens	168-188
25834305-8	2015	Fas- and p62-expressing histiocytes were co-localized in granulomas with silica particles that showed an increase of iron levels on silica particles in mouse lungs.	Iron	117-121	sequestosome 1	Mus musculus	9-12
25994136-13	2015	The mRNA expression of divalent metal transporter-1 (DMT-1), an iron absorption-related gene, was elevated in the duodenum of HFD-fed mice.	Iron	64-68	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	23-51
23754812-6	2013	In addition, we were able to complement a yeast mutant in the cytosolic Fe-S cluster assembly pathway, dre2, with the Arabidopsis homologue AtDRE2, but only when expressed together with the diflavin reductase AtTAH18.	Iron	72-76	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi	Arabidopsis thaliana	103-107
23754812-6	2013	In addition, we were able to complement a yeast mutant in the cytosolic Fe-S cluster assembly pathway, dre2, with the Arabidopsis homologue AtDRE2, but only when expressed together with the diflavin reductase AtTAH18.	Iron	72-76	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi	Arabidopsis thaliana	140-146
23754812-7	2013	Spectroscopic characterization showed that purified AtDRE2 could bind up to two Fe-S clusters.	Iron	80-84	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi	Arabidopsis thaliana	52-58
25994136-13	2015	The mRNA expression of divalent metal transporter-1 (DMT-1), an iron absorption-related gene, was elevated in the duodenum of HFD-fed mice.	Iron	64-68	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	53-58
23761763-0	2013	Application of circuit simulation method for differential modeling of TIM-2 iron uptake and metabolism in mouse kidney cells.	Iron	76-80	T cell immunoglobulin and mucin domain containing 2	Mus musculus	70-75
24854990-0	2015	Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron.	Iron	9-13	splicing factor 3b subunit 1	Homo sapiens	30-35
23761763-5	2013	The internal controlling parameters of TIM-2 associated iron metabolism were extracted and the ratios of iron movement among cellular compartments were quantified by ADS.	Iron	56-60	T cell immunoglobulin and mucin domain containing 2	Mus musculus	39-44
24854990-5	2015	Here we showcase the differences in iron architecture of SF3B1-mutant and wild-type (WT) RARS/-T and provide new mechanistic insights by which SF3B1 mutations lead to differences in iron.	Iron	36-40	splicing factor 3b subunit 1	Homo sapiens	57-62
24854990-5	2015	Here we showcase the differences in iron architecture of SF3B1-mutant and wild-type (WT) RARS/-T and provide new mechanistic insights by which SF3B1 mutations lead to differences in iron.	Iron	182-186	splicing factor 3b subunit 1	Homo sapiens	143-148
26146528-4	2015	These results suggest that grafted NSCs have an influence on improving the content of CP expression, which may play a neuroprotective role by decreasing iron deposition and ameliorating damage of dopaminergic neurons and possibly underline the iron-related common mechanism of Parkinson"s disease and Wilson"s disease.	Iron	153-157	ceruloplasmin	Rattus norvegicus	86-88
23389292-1	2013	Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC).	Iron	136-140	homeostatic iron regulator	Homo sapiens	104-107
23389292-9	2013	Our results suggest that H63D variant in HFE gene seems to be associated with GC risk of the non-cardia region and intestinal type, possibly due to its association with iron overload although a role for other mechanisms cannot be entirely ruled out.	Iron	169-173	homeostatic iron regulator	Homo sapiens	41-44
26146528-4	2015	These results suggest that grafted NSCs have an influence on improving the content of CP expression, which may play a neuroprotective role by decreasing iron deposition and ameliorating damage of dopaminergic neurons and possibly underline the iron-related common mechanism of Parkinson"s disease and Wilson"s disease.	Iron	244-248	ceruloplasmin	Rattus norvegicus	86-88
25262292-6	2015	The first group of elements (Al, Fe, Mn, Ti, U and V) showed strong inter-relationships, impoverishment in Fez particles/sediments and stable partition coefficient (Kd), linked to their lithogenic origin from Sebou watershed erosion.	Iron	33-35	FEZ family zinc finger 1	Homo sapiens	107-110
23420905-7	2013	Moreover, iron status biomarkers (ie, ferritin and soluble transferrin receptor) were significantly associated with inflammatory parameters.	Iron	10-14	transferrin receptor	Homo sapiens	59-79
25265583-3	2014	However, the efficient use of treated natural containing Fe-clay is restricted due to the loss in BET surface area during thermal treatment process.	Iron	57-59	delta/notch like EGF repeat containing	Homo sapiens	98-101
23508953-0	2013	Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism.	Iron	116-120	CREB regulated transcription coactivator 1	Mus musculus	41-47
23508953-6	2013	Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply.	Iron	79-83	CREB regulated transcription coactivator 1	Mus musculus	42-48
23508953-6	2013	Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply.	Iron	141-145	CREB regulated transcription coactivator 1	Mus musculus	42-48
23508953-7	2013	We conclude that the mTORC1 pathway serves to modulate iron metabolism and homeostasis, and we speculate that iron deprivation may be an adjunct in the treatment of cancers characterized by constitutive mTORC1 activation.	Iron	55-59	CREB regulated transcription coactivator 1	Mus musculus	21-27
23508953-7	2013	We conclude that the mTORC1 pathway serves to modulate iron metabolism and homeostasis, and we speculate that iron deprivation may be an adjunct in the treatment of cancers characterized by constitutive mTORC1 activation.	Iron	110-114	CREB regulated transcription coactivator 1	Mus musculus	203-209
25398327-2	2014	We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that binds to bacterial siderophores and starves them for iron, thus representing a novel host defense mechanism to infection.	Iron	144-148	lipocalin 2	Mus musculus	37-48
23295455-3	2013	Here we report that arsenic activates the iron responsive transcription factor, Aft1, as a consequence of a defective high-affinity iron uptake mediated by Fet3 and Ftr1, whose mRNAs are drastically decreased upon arsenic exposure.	Iron	132-136	ferroxidase FET3	Saccharomyces cerevisiae S288C	156-160
23295455-6	2013	Finally we provide data suggesting that arsenic also disrupts iron uptake in mammals and the link between Fet3, arsenic and iron, can be relevant to clinical applications.	Iron	124-128	ferroxidase FET3	Saccharomyces cerevisiae S288C	106-110
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	81-85	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	162-190
23399907-2	2013	Iron impregnated on the chrysotile surface at 1, 5 and 15 wt% was used as catalyst to grow carbon nanostructures by CVD (chemical vapor deposition) with ethanol at 800 C. Raman, TG/DTA, Mossbauer, XRD, BET, SEM, TEM, elemental analyses and contact angle measurements suggested the formation of a complex amphiphilic material containing up to 21% of nanostructured hydrophobic carbon supported on hydrophilic Mg silicate fibers with magnetic Fe cores protected by carbon coating.	Iron	0-4	delta/notch like EGF repeat containing	Homo sapiens	202-205
25398327-2	2014	We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that binds to bacterial siderophores and starves them for iron, thus representing a novel host defense mechanism to infection.	Iron	144-148	lipocalin 2	Mus musculus	50-54
24735882-2	2014	We hypothesized that the soluble transferrin receptor (sTfR) and hepcidin may provide more information than ferritin in assessing iron status in children with CF.	Iron	130-134	transferrin receptor	Homo sapiens	33-53
23388070-3	2013	The porous surfaces coated with Group VIII and IB nanocrystals (such as Fe, Co, Ni, Cu, and Ag) can not only present multiscale surface roughness, but also readily coordinate with thiols, leading to special wettability.	Iron	72-74	cytochrome c oxidase subunit 8A	Homo sapiens	38-42
23063643-2	2013	Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS.	Iron	29-33	homeostatic iron regulator	Homo sapiens	22-25
23063643-2	2013	Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS.	Iron	47-51	homeostatic iron regulator	Homo sapiens	22-25
25204651-5	2014	Furthermore, we identified the iron-sulfur cluster scaffold protein IscU as a new substrate of MK2 both in Drosophila cells and in mammalian cells.	Iron	31-35	MAP kinase activated protein-kinase-2	Drosophila melanogaster	95-98
23574943-1	2013	Oxidative stress has been implicated in the pathogenesis of Friedreich"s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein responsible of iron homeostasis.	Iron	203-207	frataxin	Homo sapiens	81-85
23574943-1	2013	Oxidative stress has been implicated in the pathogenesis of Friedreich"s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein responsible of iron homeostasis.	Iron	203-207	frataxin	Homo sapiens	154-162
22462691-0	2013	The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.	Iron	4-8	SMAD family member 4	Homo sapiens	73-78
22941037-10	2013	This finding provides new insight into how tumor cells overcome the interference of iron intake to survive and forms the basis of a new therapeutic strategy involving the development of anti-TfR mAb combined with sinomenine hydrochloride for liver cancer.	Iron	84-88	transferrin receptor	Homo sapiens	191-194
25265969-2	2014	A discharge voltage of about 2.52 V versus Mg/Mg(2+) corresponding to the redox couples of Fe(3+)/Fe(2+) was predicted for tavorite-Mg0.5FeSO4F, and the experimental diffusion coefficient for the Mg-vacancy in Mg0.5-xFeSO4F is expected to be of the same order of magnitude as that of the Li-vacancy in Li1-xFeSO4F.	Iron	91-93	transglutaminase 1	Homo sapiens	302-305
23524962-3	2013	demonstrate that administration of antisense oligonucleotides that reduce expression of Tmprss6, a hepatic protein that plays an essential role in maintaining iron balance, can attenuate disease severity in mouse models of human iron overload disorders.	Iron	159-163	transmembrane serine protease 6	Mus musculus	88-95
23524962-3	2013	demonstrate that administration of antisense oligonucleotides that reduce expression of Tmprss6, a hepatic protein that plays an essential role in maintaining iron balance, can attenuate disease severity in mouse models of human iron overload disorders.	Iron	229-233	transmembrane serine protease 6	Mus musculus	88-95
25038477-5	2014	While the iron affected the enzymatic activity of G6PD, GSR, GST, and GPX, it had no significant effect on 6PGD activity in the rat kidney.	Iron	10-14	glucose-6-phosphate dehydrogenase	Rattus norvegicus	50-54
23499446-4	2013	Notably, we identified the succination of three cysteine residues in mitochondrial Aconitase2 (ACO2) crucial for iron-sulfur cluster binding.	Iron	113-117	aconitase 2, mitochondrial	Mus musculus	83-93
23499446-4	2013	Notably, we identified the succination of three cysteine residues in mitochondrial Aconitase2 (ACO2) crucial for iron-sulfur cluster binding.	Iron	113-117	aconitase 2, mitochondrial	Mus musculus	95-99
23499446-5	2013	We show that fumarate exerts a dose-dependent inhibition of ACO2 activity, which correlates with increased succination as determined by mass spectrometry, possibly by interfering with iron chelation.	Iron	184-188	aconitase 2, mitochondrial	Mus musculus	60-64
23193175-5	2013	When coexpressed with NSP2, an NSP5 mutant devoid of the iron-sulfur cluster still forms viroplasm-like structures.	Iron	57-61	reticulon 2	Homo sapiens	22-26
23202722-3	2013	TfR is regulated by both iron and nitric oxide (NO), the molecule produced by endothelial nitric oxide synthase (eNOS).	Iron	25-29	transferrin receptor	Homo sapiens	0-3
25038477-6	2014	In conclusion, we reported here that the gene expression of G6pd, 6pgd, Gsr, Gpx, and Gst did not correlate to enzyme activity, and the actual effect of long-term iron overload on renal antioxidant system is observed at protein level.	Iron	163-167	glucose-6-phosphate dehydrogenase	Rattus norvegicus	60-64
23523353-4	2013	IRPs thus secure sufficient iron transport across absorptive enterocytes by restricting the ferritin "mucosal block" and define a basal set point for iron absorption upon which IRP-independent systemic regulatory inputs are overlaid.	Iron	28-32	Wnt family member 2	Homo sapiens	0-3
25462017-0	2014	The mitochondrial proteins AtHscB and AtIsu1 involved in Fe-S cluster assembly interact with the Hsp70-type chaperon AtHscA2 and modulate its catalytic activity.	Iron	57-59	SufE/NifU family protein	Arabidopsis thaliana	38-44
23523353-4	2013	IRPs thus secure sufficient iron transport across absorptive enterocytes by restricting the ferritin "mucosal block" and define a basal set point for iron absorption upon which IRP-independent systemic regulatory inputs are overlaid.	Iron	150-154	Wnt family member 2	Homo sapiens	0-3
23416069-3	2013	Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors.	Iron	148-152	transferrin receptor	Homo sapiens	72-92
23416069-3	2013	Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors.	Iron	148-152	transferrin receptor	Homo sapiens	94-98
23292780-10	2013	This study identifies chromosomal loci associated with netB-positive poultry strains, suggesting that the chromosomal background can confer a selective advantage to NE-causing strains, possibly through mechanisms involving iron acquisition, carbohydrate metabolism, and plasmid maintenance.	Iron	223-227	netB	Clostridium perfringens	55-59
25285190-8	2013	The level and location of mNP/Fe in blood and normal/tumor tissue is assessed via histopathological methods (confocal, light and electron microscopy, histochemical iron staining, fluorescent labeling, TEM) and ICP-MS.	Iron	164-168	modifier of Niemann Pick type C1	Mus musculus	26-29
23426685-3	2013	Previous studies in our laboratory showed that NMDA receptor activation, via NO and Dexras1, physiologically stimulates DMT1, the major iron importer.	Iron	136-140	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	120-124
23421845-0	2013	Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome.	Iron	34-38	Wnt family member 2	Homo sapiens	82-85
25462017-7	2014	Results suggest that AtHscA2 in cooperation with AtIsu1 and AtHscB play an important role in the regulation of the Fe-S assembly pathway in plant mitochondria.	Iron	115-119	SufE/NifU family protein	Arabidopsis thaliana	49-55
25389409-7	2014	Following Hb-Hp binding to CD163, cellular internalization of the complex leads to globin and heme metabolism, which is followed by adaptive changes in antioxidant and iron metabolism pathways and macrophage phenotype polarization.	Iron	168-172	hemoglobin subunit alpha 1	Homo sapiens	10-15
23269675-2	2013	This gene normally encodes the iron-binding protein frataxin (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and antioxidant protection.	Iron	31-35	frataxin	Homo sapiens	52-60
23269675-2	2013	This gene normally encodes the iron-binding protein frataxin (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and antioxidant protection.	Iron	31-35	frataxin	Homo sapiens	62-65
23269675-2	2013	This gene normally encodes the iron-binding protein frataxin (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and antioxidant protection.	Iron	104-108	frataxin	Homo sapiens	52-60
23269675-2	2013	This gene normally encodes the iron-binding protein frataxin (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and antioxidant protection.	Iron	104-108	frataxin	Homo sapiens	62-65
23269675-2	2013	This gene normally encodes the iron-binding protein frataxin (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and antioxidant protection.	Iron	104-108	frataxin	Homo sapiens	52-60
23269675-2	2013	This gene normally encodes the iron-binding protein frataxin (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and antioxidant protection.	Iron	104-108	frataxin	Homo sapiens	62-65
23298529-4	2013	Copper (Cu) plays an important role as prosthetic group of several proteins involved in iron metabolism and antioxidant responses, such as ceruloplasmin (Cp).	Iron	88-92	ceruloplasmin	Rattus norvegicus	139-152
23202722-4	2013	We hypothesized that limited placental development downregulates both placental TfR and eNOS expression, thereby lowering fetal tissue iron.	Iron	135-139	transferrin receptor	Homo sapiens	80-83
23202722-10	2013	TfR was localized throughout the placentome, including the hemophagous zone, implicating a role for TfR in ovine placental iron transport.	Iron	123-127	transferrin receptor	Homo sapiens	0-3
23202722-10	2013	TfR was localized throughout the placentome, including the hemophagous zone, implicating a role for TfR in ovine placental iron transport.	Iron	123-127	transferrin receptor	Homo sapiens	100-103
23269675-4	2013	The lack of FXN in turn impairs incorporation of iron into iron-sulfur cluster and heme cofactors, causing widespread enzymatic deficits and oxidative damage catalyzed by excess labile iron.	Iron	49-53	frataxin	Homo sapiens	12-15
23269675-4	2013	The lack of FXN in turn impairs incorporation of iron into iron-sulfur cluster and heme cofactors, causing widespread enzymatic deficits and oxidative damage catalyzed by excess labile iron.	Iron	59-63	frataxin	Homo sapiens	12-15
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	102-106	aconitase 1	Homo sapiens	110-135
23269675-4	2013	The lack of FXN in turn impairs incorporation of iron into iron-sulfur cluster and heme cofactors, causing widespread enzymatic deficits and oxidative damage catalyzed by excess labile iron.	Iron	59-63	frataxin	Homo sapiens	12-15
22241739-2	2013	In addition, iron metabolism is controlled by several local regulatory mechanisms including IRP and Hif-2alpha activities independently of hepcidin.	Iron	13-17	wingless-type MMTV integration site family, member 2	Mus musculus	92-95
22241739-9	2013	In addition, significant inductive effects of iron-deficient diet on Dcytb and DMT1 mRNA expression in the duodenum were noted with more pronounced effects in Hamp (-/-) mice compared with controls.	Iron	46-50	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	79-83
23334592-3	2013	Low frataxin levels lead to insufficient biosynthesis of iron-sulfur clusters that are required for mitochondrial electron transport and assembly of functional aconitase, and iron dysmetabolism of the entire cell.	Iron	57-61	frataxin	Homo sapiens	4-12
23334592-3	2013	Low frataxin levels lead to insufficient biosynthesis of iron-sulfur clusters that are required for mitochondrial electron transport and assembly of functional aconitase, and iron dysmetabolism of the entire cell.	Iron	175-179	frataxin	Homo sapiens	4-12
22443990-8	2013	Serum ferritin levels were significantly higher (P &lt; 0 0001) and transferrin receptor (TfR) was significantly lower (P = 0 003) among infants (n 188) meeting the Fe supplementation recommendation compared to those (n 67) not meeting the recommendation.	Iron	165-167	transferrin receptor	Homo sapiens	68-88
22443990-8	2013	Serum ferritin levels were significantly higher (P &lt; 0 0001) and transferrin receptor (TfR) was significantly lower (P = 0 003) among infants (n 188) meeting the Fe supplementation recommendation compared to those (n 67) not meeting the recommendation.	Iron	165-167	transferrin receptor	Homo sapiens	90-93
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	102-106	aconitase 1	Homo sapiens	137-141
22443990-10	2013	In conclusion, this study confirmed that Fe status of infants following the Danish Fe supplementation recommendation was significantly associated with increased serum ferritin and decreased levels of TfR indicating more favourable Fe status, compared to infants not following the recommendation.	Iron	41-43	transferrin receptor	Homo sapiens	200-203
22443990-10	2013	In conclusion, this study confirmed that Fe status of infants following the Danish Fe supplementation recommendation was significantly associated with increased serum ferritin and decreased levels of TfR indicating more favourable Fe status, compared to infants not following the recommendation.	Iron	83-85	transferrin receptor	Homo sapiens	200-203
22443990-10	2013	In conclusion, this study confirmed that Fe status of infants following the Danish Fe supplementation recommendation was significantly associated with increased serum ferritin and decreased levels of TfR indicating more favourable Fe status, compared to infants not following the recommendation.	Iron	83-85	transferrin receptor	Homo sapiens	200-203
23178241-1	2013	Two single nucleotide polymorphisms (SNPs) in the Human Hemochromatosis (HFE) gene, C282Y and H63D, are the major variants associated to altered iron status and it is well known that these mutations are in linkage disequilibrium with certain Human Leukocyte Antigen (HLA)-A alleles.	Iron	145-149	homeostatic iron regulator	Homo sapiens	73-76
23178241-12	2013	These results suggest that it may be useful to test for both HFE H63D and C282Y polymorphisms in patients with iron overload, as opposed to just genotyping for the C282Y SNP, which is customary in some healthcare centers.	Iron	111-115	homeostatic iron regulator	Homo sapiens	61-64
23086747-3	2013	To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2.	Iron	90-94	transferrin receptor	Mus musculus	131-135
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	110-114	aconitase 1	Homo sapiens	137-141
23086747-3	2013	To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2.	Iron	90-94	lipocalin 2	Mus musculus	146-150
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	175-179	aconitase 1	Homo sapiens	110-135
23086747-3	2013	To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2.	Iron	194-198	transferrin receptor	Mus musculus	131-135
23086747-3	2013	To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2.	Iron	194-198	transferrin receptor	Mus musculus	300-304
23135277-5	2013	Mice containing a single functional Fbxl5 allele behave like their wild type littermates when fed an iron-sufficient diet.	Iron	101-105	F-box and leucine-rich repeat protein 5	Mus musculus	36-41
23135277-7	2013	The responsiveness of IRP2 to low iron is specifically enhanced in the duodena of the heterozygotes and is accompanied by increased expression of the divalent metal transporter-1.	Iron	34-38	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	150-178
23086747-3	2013	To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2.	Iron	194-198	lipocalin 2	Mus musculus	309-313
23135277-8	2013	These results confirm the role of FBXL5 in the in vivo maintenance of cellular and systemic iron homeostasis and reveal a privileged role for the intestine in their regulation by virtue of its unique FBXL5 iron sensitivity.	Iron	92-96	F-box and leucine-rich repeat protein 5	Mus musculus	34-39
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	175-179	aconitase 1	Homo sapiens	137-141
23135277-8	2013	These results confirm the role of FBXL5 in the in vivo maintenance of cellular and systemic iron homeostasis and reveal a privileged role for the intestine in their regulation by virtue of its unique FBXL5 iron sensitivity.	Iron	206-210	F-box and leucine-rich repeat protein 5	Mus musculus	200-205
25012650-7	2014	Therefore, our findings point to IRP1 as the missing link to explain the function of mitoNEET in the control of mitochondrial iron homeostasis.	Iron	126-130	aconitase 1	Homo sapiens	33-37
25085595-2	2014	Lactoferrin has many functions, including antimicrobial, immunomodulatory, and iron binding.	Iron	79-83	lactotransferrin	Sus scrofa	0-11
25206366-2	2013	Multiple iron metabolism proteins are expressed in the brain including transferrin receptor and ferritin-H.	Iron	9-13	transferrin receptor	Homo sapiens	71-91
25206366-4	2013	Here, using an in vitro cultured differentiation model of oligodendrocytes, we found that both transferrin receptor and ferritin-H are significantly upregulated during oligodendrocyte maturation, implying the essential role of iron in the development of oligodendrocytes.	Iron	227-231	transferrin receptor	Homo sapiens	95-115
24368960-12	2013	The HFE gene H63D mutation underlies Hereditary Haemochromatosis (HH), which needs treatment to prevent organ damages by iron overload.	Iron	121-125	homeostatic iron regulator	Homo sapiens	4-7
24770882-4	2014	Comparative sequence analysis with transferrin from other species revealed two major putative iron-binding domains designated as the N-lobe and the C-lobe in accordance with the transferrin protein characteristics.	Iron	94-98	serotransferrin-like	Oreochromis niloticus	35-46
23016685-0	2013	Matriptase-2, a regulatory protease of iron homeostasis: possible substrates, cleavage sites and inhibitors.	Iron	39-43	transmembrane serine protease 6	Mus musculus	0-12
23016685-5	2013	Since prospective studies revealed that genetic inactivation of matriptase-2 reduces iron loading in different mouse models, matriptase-2 becomes highly attractive as a novel target for the design of low-molecular weight inhibitors.	Iron	85-89	transmembrane serine protease 6	Mus musculus	64-76
23016685-5	2013	Since prospective studies revealed that genetic inactivation of matriptase-2 reduces iron loading in different mouse models, matriptase-2 becomes highly attractive as a novel target for the design of low-molecular weight inhibitors.	Iron	85-89	transmembrane serine protease 6	Mus musculus	125-137
23876871-2	2013	The Fe-S clusters are assembled by one of four distinct systems: NIF, SUF, ISC, and CIA machineries.	Iron	4-8	S100 calcium binding protein A8	Homo sapiens	65-68
24770882-4	2014	Comparative sequence analysis with transferrin from other species revealed two major putative iron-binding domains designated as the N-lobe and the C-lobe in accordance with the transferrin protein characteristics.	Iron	94-98	serotransferrin-like	Oreochromis niloticus	178-189
25387027-5	2013	In pigs and horses, for example, iron is transported as uteroferrin secreted from the uterine glands and taken up by areolas.	Iron	33-37	acid phosphatase 5, tartrate resistant	Equus caballus	56-67
23657305-6	2013	Associations between HFE mutations and risk of excessive liver iron stores, abnormal serum ferritin, liver fibrosis, or necroinflammatory activity were assessed by multivariate logistic regression analysis.	Iron	63-67	homeostatic iron regulator	Homo sapiens	21-24
22945607-7	2013	Normal weight children supplemented with iron had significantly lower TfR concentrations at endpoint than the OW children supplemented with iron and the children receiving placebo.	Iron	41-45	transferrin receptor	Homo sapiens	70-73
22945607-9	2013	In the children supplemented with iron, baseline hepcidin and BAZ were significant predictors of endpoint TfR, with a trend towards a hepcidin x BAZ interaction (P=0.058).	Iron	34-38	transferrin receptor	Homo sapiens	106-109
24770882-5	2014	The predicted tertiary structure of tilapia transferrin confirmed the presence of iron and anion-binding sites on both lobes that are conserved among transferrins from other species.	Iron	82-86	serotransferrin-like	Oreochromis niloticus	44-55
24770882-9	2014	The expression pattern of the transferrin gene and the iron levels of infected tilapia in this study were consistent with the function of transferrin in innate immunity.	Iron	55-59	serotransferrin-like	Oreochromis niloticus	138-149
23478311-0	2013	Prion protein regulates iron transport by functioning as a ferrireductase.	Iron	24-28	prion protein	Mus musculus	0-13
25239548-2	2014	Further studies have also implicated Rim101 in the responses to other stresses, and have shown its genetic interaction with the iron deprivation-responsive factor Aft1.	Iron	128-132	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	37-43
23478311-3	2013	When exposed to non-transferrin-bound (NTB) radioactive-iron (59FeCl3) by gastric-gavage, PrP-/- mice absorb significantly more 59Fe from the intestinal lumen relative to controls, indicating appropriate systemic response to the iron deficiency.	Iron	55-60	prion protein	Mus musculus	90-93
23478311-5	2013	Bone marrow (BM) preparations of PrP-/- mice on normal diet show relatively less stainable iron, and this phenotype is only partially corrected by intraperitoneal administration of excess iron-dextran.	Iron	91-95	prion protein	Mus musculus	33-36
23478311-6	2013	Cultured PrP-/- BM-macrophages incorporate significantly less NTB-59Fe in the absence or presence of excess extracellular iron, indicating reduced uptake and/or storage of available iron in the absence of PrPC.	Iron	182-186	prion protein	Mus musculus	9-12
23478311-8	2013	Incorporation of NTB-59Fe by neuroblastoma cells correlates with FR activity of PrPC, implicating PrPC in cellular iron uptake and metabolism.	Iron	115-119	prion protein	Mus musculus	80-84
23478311-8	2013	Incorporation of NTB-59Fe by neuroblastoma cells correlates with FR activity of PrPC, implicating PrPC in cellular iron uptake and metabolism.	Iron	115-119	prion protein	Mus musculus	98-102
23478311-9	2013	These observations explain the correlation between PrPC expression and cellular iron levels, and the cause of iron imbalance in sporadic-Creutzfeldt-Jakob-disease brains where PrPC accumulates as insoluble aggregates.	Iron	80-84	prion protein	Mus musculus	51-55
23478311-9	2013	These observations explain the correlation between PrPC expression and cellular iron levels, and the cause of iron imbalance in sporadic-Creutzfeldt-Jakob-disease brains where PrPC accumulates as insoluble aggregates.	Iron	110-114	prion protein	Mus musculus	176-180
24635122-5	2014	HFE genotyping was performed on subjects with significant liver, cardiac and/or pancreatic iron.	Iron	91-95	homeostatic iron regulator	Homo sapiens	0-3
22992462-0	2013	The Nramp (Slc11) proteins regulate development, resistance to pathogenic bacteria and iron homeostasis in Dictyostelium discoideum.	Iron	87-91	solute carrier family 34 member 1	Homo sapiens	11-16
24399095-1	2014	There is a general consensus that HFE- related Hereditary Haemochromatosis (HFE-HH) should be diagnosed at early stages in pre-symptomatic individuals, in order to prevent the most severe consequences of iron overload.	Iron	204-208	homeostatic iron regulator	Homo sapiens	34-37
23449741-13	2013	CONCLUSION: HbA1c is not affected by the blood sugar levels alone, and there are various confounding factors when HbA1c is measured, especially that of iron de.ciency, which is the commonest of the de.ciency diseases worldwide.	Iron	152-156	hemoglobin subunit alpha 1	Homo sapiens	114-118
22862424-1	2013	Mitochondrial frataxin is involved in various functions such as iron homeostasis, iron-sulfur cluster biogenesis, the protection from oxidative stress and apoptosis and acts as a tumor suppressor protein.	Iron	64-68	frataxin	Homo sapiens	14-22
22862424-1	2013	Mitochondrial frataxin is involved in various functions such as iron homeostasis, iron-sulfur cluster biogenesis, the protection from oxidative stress and apoptosis and acts as a tumor suppressor protein.	Iron	82-86	frataxin	Homo sapiens	14-22
22862424-3	2013	The bacterial expression of human frataxin stimulated maturation of human ferrochelatase, which catalyzes the insertion of iron into protoporphyrin at the last step of heme biosynthesis.	Iron	123-127	frataxin	Homo sapiens	34-42
23723737-1	2013	Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life.	Iron	72-76	transferrin receptor	Homo sapiens	0-20
23520547-0	2013	Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae.	Iron	22-26	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	101-106
23520547-5	2013	Additionally, treatment of curcumin caused the iron starvation induced expression of FET3, FRE1 genes.	Iron	47-51	ferroxidase FET3	Saccharomyces cerevisiae S288C	85-89
23115244-0	2012	Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.	Iron	114-118	frataxin	Homo sapiens	57-65
24175256-0	2012	Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease.	Iron	26-30	homeostatic iron regulator	Homo sapiens	13-16
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	71-75	homeostatic iron regulator	Homo sapiens	43-46
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	157-161	homeostatic iron regulator	Homo sapiens	43-46
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	157-161	homeostatic iron regulator	Homo sapiens	43-46
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	157-161	homeostatic iron regulator	Homo sapiens	43-46
24175256-4	2012	However, in hemodialysis patients, carriage of HFE mutations may confer an adaptive benefit by decreasing hepcidin release in response to iron infusion and inflammation, thereby improving iron availability to erythropoiesis, anemia control, the response to Epo, and possibly survival.	Iron	138-142	homeostatic iron regulator	Homo sapiens	47-50
24175256-4	2012	However, in hemodialysis patients, carriage of HFE mutations may confer an adaptive benefit by decreasing hepcidin release in response to iron infusion and inflammation, thereby improving iron availability to erythropoiesis, anemia control, the response to Epo, and possibly survival.	Iron	188-192	homeostatic iron regulator	Homo sapiens	47-50
24175256-6	2012	However, HFE mutations directly favor hemoglobinization independently of hepcidin, and reduce macrophages activation in response to inflammation, whereas hepcidin might also play a beneficial anti-inflammatory and anti-microbic action during sepsis, so that direct inhibition of HFE-mediated regulation of iron metabolism may represent a valuable alternative therapeutic target.	Iron	306-310	homeostatic iron regulator	Homo sapiens	9-12
22884880-0	2012	Iron increases liver injury through oxidative/nitrative stress in diabetic rats: Involvement of nitrotyrosination of glucokinase.	Iron	0-4	glucokinase	Rattus norvegicus	117-128
22884880-7	2012	Consequently, the extent of oxidized/nitrated glucokinase was markedly increased in the iron-treated diabetic rats that contribute to a decrease in its expression and activity.	Iron	88-92	glucokinase	Rattus norvegicus	46-57
22884880-8	2012	Further studies revealed a significant contribution of iron-induced specific glucokinase nitration sites to its inactivation.	Iron	55-59	glucokinase	Rattus norvegicus	77-88
23657305-12	2013	In ALD patients, however, the presence of at least one HFE mutation increases the risk of having excessive liver iron stores but has no detectable effects on liver disease activity or severity.	Iron	113-117	homeostatic iron regulator	Homo sapiens	55-58
23064556-0	2013	Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster.	Iron	31-35	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
23064556-0	2013	Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster.	Iron	58-62	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
23064556-3	2013	The functional role of secretory ferritin in iron homeostasis remains poorly understood in insects as well as in mammalians.	Iron	45-49	Ferritin 1 heavy chain homologue	Drosophila melanogaster	33-41
23064556-4	2013	Here we used Drosophila to dissect the involvement of ferritin in insect iron metabolism.	Iron	73-77	Ferritin 1 heavy chain homologue	Drosophila melanogaster	54-62
23064556-5	2013	Midgut-specific knockdown of ferritin resulted in iron accumulation in the gut but systemic iron deficiency (37% control), accompanied by retarded development and reduced survival (3% survival), and was rescued by dietary iron supplementation (50% survival) or exacerbated by iron depletion (0% survival).	Iron	50-54	Ferritin 1 heavy chain homologue	Drosophila melanogaster	29-37
23064556-5	2013	Midgut-specific knockdown of ferritin resulted in iron accumulation in the gut but systemic iron deficiency (37% control), accompanied by retarded development and reduced survival (3% survival), and was rescued by dietary iron supplementation (50% survival) or exacerbated by iron depletion (0% survival).	Iron	92-96	Ferritin 1 heavy chain homologue	Drosophila melanogaster	29-37
23064556-5	2013	Midgut-specific knockdown of ferritin resulted in iron accumulation in the gut but systemic iron deficiency (37% control), accompanied by retarded development and reduced survival (3% survival), and was rescued by dietary iron supplementation (50% survival) or exacerbated by iron depletion (0% survival).	Iron	92-96	Ferritin 1 heavy chain homologue	Drosophila melanogaster	29-37
23064556-6	2013	These results suggest an essential role of ferritin in removing iron from enterocytes across the basolateral membrane.	Iron	64-68	Ferritin 1 heavy chain homologue	Drosophila melanogaster	43-51
23064556-7	2013	Expression of wild-type ferritin in the midgut, especially in the iron cell region, could significantly rescue ferritin-null mutants (first-instar larvae rescued up to early adults), indicating iron deficiency as the major cause of early death for ferritin flies.	Iron	66-70	Ferritin 1 heavy chain homologue	Drosophila melanogaster	24-32
23064556-7	2013	Expression of wild-type ferritin in the midgut, especially in the iron cell region, could significantly rescue ferritin-null mutants (first-instar larvae rescued up to early adults), indicating iron deficiency as the major cause of early death for ferritin flies.	Iron	66-70	Ferritin 1 heavy chain homologue	Drosophila melanogaster	111-119
23064556-7	2013	Expression of wild-type ferritin in the midgut, especially in the iron cell region, could significantly rescue ferritin-null mutants (first-instar larvae rescued up to early adults), indicating iron deficiency as the major cause of early death for ferritin flies.	Iron	66-70	Ferritin 1 heavy chain homologue	Drosophila melanogaster	111-119
23064556-8	2013	In many nonintestinal tissues, tissue-specific ferritin knockdown also caused local iron accumulation (100% increase) and resulted in severe tissue damage, as evidenced by cell loss.	Iron	84-88	Ferritin 1 heavy chain homologue	Drosophila melanogaster	47-55
23064556-9	2013	Overall, our study demonstrated Drosophila ferritin is essential to two key aspects of iron homeostasis: dietary iron absorption and tissue iron detoxification.	Iron	87-91	Ferritin 1 heavy chain homologue	Drosophila melanogaster	43-51
23064556-9	2013	Overall, our study demonstrated Drosophila ferritin is essential to two key aspects of iron homeostasis: dietary iron absorption and tissue iron detoxification.	Iron	113-117	Ferritin 1 heavy chain homologue	Drosophila melanogaster	43-51
23064556-9	2013	Overall, our study demonstrated Drosophila ferritin is essential to two key aspects of iron homeostasis: dietary iron absorption and tissue iron detoxification.	Iron	113-117	Ferritin 1 heavy chain homologue	Drosophila melanogaster	43-51
23098241-1	2013	AIM: Hemochromatosis is a common disorder of iron overload most commonly due to homozogosity for the HFE C282Y substitution.	Iron	45-49	homeostatic iron regulator	Homo sapiens	101-104
24025247-6	2013	In this study, we investigated the effect of Fe-ion beams with an LET of 640 keV mum(-1) on both the mutation frequency and the molecular nature of the mutations.	Iron	45-47	LEUNIG-like protein	Arabidopsis thaliana	81-87
25075539-3	2014	Most human hereditary hemochromatosis cases (up to 90%) are caused by a point mutation in the hfe gene, resulting in a C282Y substitution leading to iron accumulation.	Iron	149-153	homeostatic iron regulator	Homo sapiens	94-97
24319154-8	2013	In mice, deletion of TMPRSS6 in vivo has profound effects on the iron phenotype of hemochromatosis and beta-thalassemia.	Iron	65-69	transmembrane serine protease 6	Mus musculus	21-28
25229976-4	2014	In this study, we compared the clonogenic survival frequency of Ku80+/+ (NHEJ-proficient) and Ku80-/- (NHEJ-deficient) cells after exposure to iron (175 keV/mum), silicon (75 keV/mum), oxygen (25 keV/mum) and X ray (low-LET).	Iron	143-147	X-ray repair cross complementing 5	Homo sapiens	94-98
23262393-5	2013	Moreover, DFO intranasal administration also decreases Fe-induced the activities of cyclin-dependent kinase 5 (CDK5) and glycogen synthase kinase 3beta (GSK3beta), which in turn suppressing tau phosphorylation.	Iron	55-57	glycogen synthase kinase 3 alpha	Mus musculus	153-161
23262393-6	2013	Cumulatively, our data show that intranasal DFO treatment exerts its suppressive effects on iron induced tau phosphorylation via CDK5 and GSK3beta pathways.	Iron	92-96	glycogen synthase kinase 3 alpha	Mus musculus	138-146
23144187-3	2013	Transcriptome analysis of an Arabidopsis (Arabidopsis thaliana) mutant defective in RNA polymerase II C-terminal domain-phosphatase-like1 (CPL1) revealed significant up-regulation of Fe utilization-related genes (e.g. IRON-REGULATED TRANSPORTER1), suggesting the importance of RNA metabolism in Fe signaling.	Iron	295-297	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	102-137
25228761-3	2014	We investigate this phenomenon by studying frataxin, a protein whose normal function is to facilitate the formation of iron-sulfur clusters but whose mutations are associated with Friedreich"s ataxia.	Iron	119-123	frataxin	Homo sapiens	43-51
23144187-3	2013	Transcriptome analysis of an Arabidopsis (Arabidopsis thaliana) mutant defective in RNA polymerase II C-terminal domain-phosphatase-like1 (CPL1) revealed significant up-regulation of Fe utilization-related genes (e.g. IRON-REGULATED TRANSPORTER1), suggesting the importance of RNA metabolism in Fe signaling.	Iron	295-297	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	139-143
23144187-5	2013	Changes in protein level were less prominent than those in transcript level, indicating that cpl1-2 mainly affects the Fe deficiency response at the transcriptional level.	Iron	119-121	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	93-97
23144187-6	2013	However, Fe content was significantly increased in the roots and decreased in the shoots of cpl1-2 plants, indicating that the cpl1 mutations do indeed affect Fe homeostasis.	Iron	9-11	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	92-96
23144187-9	2013	Genetic data indicate that cpl1-2 likely activates Fe deficiency responses upstream of both FE-DEFICIENCY-INDUCED TRANSCRIPTION FACTOR-dependent and -independent signaling pathways.	Iron	51-53	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	27-33
23144187-9	2013	Genetic data indicate that cpl1-2 likely activates Fe deficiency responses upstream of both FE-DEFICIENCY-INDUCED TRANSCRIPTION FACTOR-dependent and -independent signaling pathways.	Iron	92-94	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	27-33
23144187-10	2013	Interestingly, various osmotic stress/abscisic acid (ABA)-inducible genes were up-regulated in cpl1-2, and the expression of some ABA-inducible genes was controlled by Fe availability.	Iron	168-170	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	95-99
23144187-11	2013	We propose that the cpl1 mutations enhance Fe deficiency signaling and promote cross talk with a branch of the osmotic stress/ABA signaling pathway.	Iron	43-45	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	20-24
25113070-6	2014	The thermally induced changes in the Fe(II) coordination sphere are investigated in situ during annealing of a solid Fe-MEPE using X-ray absorption fine structure (XAFS) spectroscopy.	Iron	37-39	matrix extracellular phosphoglycoprotein	Homo sapiens	120-124
23520538-2	2013	Cellular iron metabolism is coordinately controlled by the Iron Regulatory Proteins (IRP1 and IRP2), whose activity is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a current and persistent environmental contaminant.	Iron	9-13	aconitase 1	Homo sapiens	85-89
23520538-2	2013	Cellular iron metabolism is coordinately controlled by the Iron Regulatory Proteins (IRP1 and IRP2), whose activity is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a current and persistent environmental contaminant.	Iron	59-63	aconitase 1	Homo sapiens	85-89
25072592-3	2014	The reaction with K[CpFe(CO)2] gives only the dehalogenated arene, but the reaction with K[Cp*Fe(CO)2] (Cp* = eta(5)-C5Me5) results in nucleophilic substitution to give [(eta(6)-C6H5FeCp*(CO)2)Cr(CO)3].	Iron	22-24	endothelin receptor type A	Homo sapiens	110-113
23349749-6	2013	Expression pattern of FOX1, FTR1 and ferredoxin was up-regulated by CO exposure in iron-deficient mediam.	Iron	83-87	uncharacterized protein	Chlamydomonas reinhardtii	22-26
23349749-6	2013	Expression pattern of FOX1, FTR1 and ferredoxin was up-regulated by CO exposure in iron-deficient mediam.	Iron	83-87	uncharacterized protein	Chlamydomonas reinhardtii	37-47
25198162-0	2014	Ethylmalonic encephalopathy ETHE1 R163W/R163Q mutations alter protein stability and redox properties of the iron centre.	Iron	108-112	ETHE1 persulfide dioxygenase	Homo sapiens	28-33
23935494-6	2013	We show that all of these metabolic outcomes can be replicated by direct targeting of viperin to mitochondria in the absence of HCMV infection, and that the motif responsible for Fe-S cluster binding by viperin is essential.	Iron	179-183	radical S-adenosyl methionine domain containing 2	Homo sapiens	203-210
22985607-1	2012	BACKGROUND &amp; AIMS: Porphyria cutanea tarda (PCT) is an iron-related disorder caused by reduced activity of hepatic uroporphyrinogen decarboxylase; it can be treated by phlebotomy or low doses of hydroxychloroquine.	Iron	59-63	uroporphyrinogen decarboxylase	Homo sapiens	119-149
25198162-1	2014	ETHE1 is an iron-containing protein from the metallo beta-lactamase family involved in the mitochondrial sulfide oxidation pathway.	Iron	12-16	ETHE1 persulfide dioxygenase	Homo sapiens	0-5
25499576-3	2013	Frataxin is involved in iron-sulfur-cluster (ISC) assembly in the mitochondrial matrix, and decreased frataxin is associated with ISC-enzyme and mitochondrial dysfunction, mitochondrial iron accumulation, and increased oxidative stress.	Iron	24-28	frataxin	Homo sapiens	0-8
25198162-6	2014	In addition, we report a number of benchmark properties of wild type human ETHE1, including for the first time the redox properties of the mononuclear iron centre.	Iron	151-155	ETHE1 persulfide dioxygenase	Homo sapiens	75-80
25198162-9	2014	ETHE1 wild type and variants bind 1 +- 0.2 mol iron/protein and no zinc; however, the variants exhibited only   10% of wild-type catalytically activity.	Iron	47-51	ETHE1 persulfide dioxygenase	Homo sapiens	0-5
25499576-3	2013	Frataxin is involved in iron-sulfur-cluster (ISC) assembly in the mitochondrial matrix, and decreased frataxin is associated with ISC-enzyme and mitochondrial dysfunction, mitochondrial iron accumulation, and increased oxidative stress.	Iron	186-190	frataxin	Homo sapiens	102-110
23064962-9	2012	The results suggested that CD61 regulates the expressions of Slc11a2 and Slc40a1, both of which are involved in iron transportation in epithelial tissues.	Iron	112-116	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	61-68
25198162-10	2014	Analysis of the redox properties of ETHE1 mononuclear iron centre revealed that the variants have lowered reduction potentials with respect to that of the wild type.	Iron	54-58	ETHE1 persulfide dioxygenase	Homo sapiens	36-41
24920245-8	2014	Quantitative real-time PCR was carried out for verifying if our aberrant mRNA is targeted for nonsense-mediated mRNA decay (NMD); we observed that patient HFE mRNA was expressed much less than calibrator, suggesting that the mutated HFE protein cannot play its role in iron metabolism regulation, resulting in proband BIO.	Iron	269-273	homeostatic iron regulator	Homo sapiens	155-158
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	253-257	transferrin receptor	Mus musculus	123-127
23280845-2	2012	Frataxin is a mitochondrial protein involved in iron homeostasis.	Iron	48-52	frataxin	Homo sapiens	0-8
24976419-0	2014	Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin.	Iron	42-46	ZFP36 ring finger protein	Homo sapiens	103-118
24976419-8	2014	Moreover, mTOR is reported to control iron metabolism through modulation of tristetraprolin expression.	Iron	38-42	ZFP36 ring finger protein	Homo sapiens	76-91
23011661-0	2012	Effect of trypsin and mucin on heme iron bioavailability in humans.	Iron	36-40	LOC100508689	Homo sapiens	22-27
23011661-1	2012	UNLABELLED: In the human gastrointestinal tract, trypsin and mucin may affect the absorption of heme iron.	Iron	101-105	LOC100508689	Homo sapiens	61-66
23011661-3	2012	We determined the effect of trypsin and mucin on heme iron absorption in humans.	Iron	54-58	LOC100508689	Homo sapiens	40-45
23011661-6	2012	Subjects ingested 100 mg trypsin and 1.7 g mucin on 5 mg heme iron bioavailability on days 1, 2, 14, and 15, respectively.	Iron	62-66	LOC100508689	Homo sapiens	43-48
23194296-1	2012	BACKGROUND: Transferrin (TF) plays a critical physiological role in cellular iron delivery via the transferrin receptor (TFR)-mediated endocytosis pathway in nearly all eukaryotic organisms.	Iron	77-81	transferrin receptor	Homo sapiens	99-119
23194296-1	2012	BACKGROUND: Transferrin (TF) plays a critical physiological role in cellular iron delivery via the transferrin receptor (TFR)-mediated endocytosis pathway in nearly all eukaryotic organisms.	Iron	77-81	transferrin receptor	Homo sapiens	121-124
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	222-226	transferrin receptor	Mus musculus	99-121
24976419-10	2014	Sustained ISCU protein levels enhanced by mTORC1 can inhibit iron-responsive element and iron-regulatory protein binding activities.	Iron	61-65	CREB regulated transcription coactivator 1	Mus musculus	42-48
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	222-226	transferrin receptor	Mus musculus	123-127
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	253-257	transferrin receptor	Mus musculus	99-121
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	253-257	transferrin receptor	Mus musculus	123-127
23140174-4	2012	We also found that inhibition of CDK2 by iron chelators leads to the inhibition of CDK9 activity, suggesting a functional link between CDK2 and CDK9.	Iron	41-45	cyclin dependent kinase 2	Homo sapiens	33-37
23140174-4	2012	We also found that inhibition of CDK2 by iron chelators leads to the inhibition of CDK9 activity, suggesting a functional link between CDK2 and CDK9.	Iron	41-45	cyclin dependent kinase 2	Homo sapiens	135-139
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	253-257	transferrin receptor	Mus musculus	99-121
25379420-1	2014	BACKGROUND: In Friedreich"s ataxia (FA) the genetically decreased expression of the mitochondrial protein frataxin leads to disturbance of the mitochondrial iron metabolism.	Iron	157-161	frataxin	Homo sapiens	106-114
22728873-1	2012	BACKGROUND &amp; AIMS: The hereditary hemochromatosis-associated membrane proteins HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone hepcidin.	Iron	154-158	homeostatic iron regulator	Homo sapiens	83-86
24916507-0	2014	Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Kruppel-like factor.	Iron	11-15	Kruppel like factor 1	Homo sapiens	72-101
22728873-7	2012	Our experiments show that like TfR2, HJV competes with TfR1 for binding to HFE, indicating that the expression of TfR2 and HJV may be critical for iron sensing.	Iron	147-151	transferrin receptor	Homo sapiens	55-59
22728873-7	2012	Our experiments show that like TfR2, HJV competes with TfR1 for binding to HFE, indicating that the expression of TfR2 and HJV may be critical for iron sensing.	Iron	147-151	homeostatic iron regulator	Homo sapiens	75-78
23045394-6	2012	The mitochondrial transporter Atm1p, which has been implicated in the export of iron-sulfur clusters and related molecules, is required not only for iron binding to Grx3p but also for dissociation of Aft1p from its target promoters.	Iron	80-84	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	30-35
23045394-6	2012	The mitochondrial transporter Atm1p, which has been implicated in the export of iron-sulfur clusters and related molecules, is required not only for iron binding to Grx3p but also for dissociation of Aft1p from its target promoters.	Iron	149-153	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	30-35
23045394-8	2012	Since Atm1p plays crucial roles in the delivery of iron-sulfur clusters from the mitochondria to the cytoplasm and nucleus, these results support the previous observations that the mitochondrial iron-sulfur cluster assembly machinery is involved in cellular iron sensing.	Iron	51-55	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	6-11
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	219-223	NFS1 cysteine desulfurase	Homo sapiens	84-88
23045394-8	2012	Since Atm1p plays crucial roles in the delivery of iron-sulfur clusters from the mitochondria to the cytoplasm and nucleus, these results support the previous observations that the mitochondrial iron-sulfur cluster assembly machinery is involved in cellular iron sensing.	Iron	195-199	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	6-11
23045394-8	2012	Since Atm1p plays crucial roles in the delivery of iron-sulfur clusters from the mitochondria to the cytoplasm and nucleus, these results support the previous observations that the mitochondrial iron-sulfur cluster assembly machinery is involved in cellular iron sensing.	Iron	195-199	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	6-11
22922699-9	2012	Consistent with these findings, iron restriction suppressed increased gene expression of collagen type III, transforming growth factor-beta, CD68, and tumor necrosis factor-alpha in the CKD kidney.	Iron	32-36	Cd68 molecule	Rattus norvegicus	141-145
22922699-10	2012	Importantly, increased expression of nuclear mineralocorticoid receptor and SGK1, a key downstream effector of mineralocorticoid receptor signaling, in the CKD kidney was markedly attenuated by iron restriction.	Iron	194-198	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	76-80
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	219-223	frataxin	Homo sapiens	163-171
24971490-2	2014	The mitochondrial Fe-S assembly complex, which consists of the cysteine desulfurase NFS1 and its accessory protein (ISD11), the Fe-S assembly protein (ISCU2), and frataxin (FXN), converts substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.	Iron	219-223	frataxin	Homo sapiens	173-176
22826563-5	2012	Ultrastructurally, SF3B1 mutants showed altered iron distribution characterized by coarse iron deposits compared with wild-type RARS patients by transmission electron microscopy.	Iron	48-52	splicing factor 3b subunit 1	Homo sapiens	19-24
22826563-5	2012	Ultrastructurally, SF3B1 mutants showed altered iron distribution characterized by coarse iron deposits compared with wild-type RARS patients by transmission electron microscopy.	Iron	90-94	splicing factor 3b subunit 1	Homo sapiens	19-24
23123858-5	2012	Mechanistically, endothelial Hb alpha haem iron in the Fe(3+) state permits NO signalling, and this signalling is shut off when Hb alpha is reduced to the Fe(2+) state by endothelial cytochrome b5 reductase 3 (CYB5R3, also known as diaphorase 1).	Iron	43-47	cytochrome b5 reductase 3	Homo sapiens	210-216
23123858-5	2012	Mechanistically, endothelial Hb alpha haem iron in the Fe(3+) state permits NO signalling, and this signalling is shut off when Hb alpha is reduced to the Fe(2+) state by endothelial cytochrome b5 reductase 3 (CYB5R3, also known as diaphorase 1).	Iron	43-47	cytochrome b5 reductase 3	Homo sapiens	232-244
23102618-0	2012	mTOR regulates cellular iron homeostasis through tristetraprolin.	Iron	24-28	ZFP36 ring finger protein	Homo sapiens	49-64
24971490-4	2014	Previous in vitro results revealed a role for human FXN in activating the cysteine desulfurase and Fe-S cluster biosynthesis activities of the Fe-S assembly complex.	Iron	99-103	frataxin	Homo sapiens	52-55
23102618-2	2012	Iron-regulatory proteins 1 and 2 (IRP1/2) have been established as important regulators of cellular iron homeostasis, but little is known about the role of other pathways in this process.	Iron	100-104	aconitase 1	Homo sapiens	0-32
23102618-2	2012	Iron-regulatory proteins 1 and 2 (IRP1/2) have been established as important regulators of cellular iron homeostasis, but little is known about the role of other pathways in this process.	Iron	100-104	aconitase 1	Homo sapiens	34-40
24971490-4	2014	Previous in vitro results revealed a role for human FXN in activating the cysteine desulfurase and Fe-S cluster biosynthesis activities of the Fe-S assembly complex.	Iron	143-147	frataxin	Homo sapiens	52-55
23102618-3	2012	Here we report that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating transferrin receptor 1 (TfR1) stability and altering cellular iron flux.	Iron	71-75	transferrin receptor	Homo sapiens	102-124
22890139-3	2012	Most patients are homozygous for the c.845G&gt;A (p.C282Y) mutation in the HFE gene; however, rare forms of genetic iron overload must be diagnosed using a specific genetic analysis.	Iron	116-120	homeostatic iron regulator	Homo sapiens	75-78
23102618-3	2012	Here we report that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating transferrin receptor 1 (TfR1) stability and altering cellular iron flux.	Iron	71-75	transferrin receptor	Homo sapiens	126-130
24971490-5	2014	Here we present radiolabeling experiments that indicate FXN accelerates the accumulation of sulfur on ISCU2 and that the resulting persulfide species is viable in the subsequent synthesis of Fe-S clusters.	Iron	191-195	frataxin	Homo sapiens	56-59
23102618-5	2012	We also show that TTP is strongly induced by iron chelation, promotes downregulation of iron-requiring genes in both mammalian and yeast cells, and modulates survival in low-iron states.	Iron	45-49	ZFP36 ring finger protein	Homo sapiens	18-21
23102618-5	2012	We also show that TTP is strongly induced by iron chelation, promotes downregulation of iron-requiring genes in both mammalian and yeast cells, and modulates survival in low-iron states.	Iron	88-92	ZFP36 ring finger protein	Homo sapiens	18-21
24971490-7	2014	These results cannot be fully explained by the hypothesis that FXN functions as an iron donor for Fe-S cluster biosynthesis, and further support an allosteric regulator role for FXN.	Iron	83-87	frataxin	Homo sapiens	63-66
23102618-5	2012	We also show that TTP is strongly induced by iron chelation, promotes downregulation of iron-requiring genes in both mammalian and yeast cells, and modulates survival in low-iron states.	Iron	88-92	ZFP36 ring finger protein	Homo sapiens	18-21
23102618-6	2012	Taken together, our data uncover a link between metabolic, inflammatory, and iron-regulatory pathways, and point toward the existence of a yeast-like TTP-mediated iron conservation program in mammals.	Iron	77-81	ZFP36 ring finger protein	Homo sapiens	150-153
22915594-4	2012	Inactivation of beta(2) can thus arise from cofactor destruction by loss of iron or Y .	Iron	76-80	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	16-23
24971490-7	2014	These results cannot be fully explained by the hypothesis that FXN functions as an iron donor for Fe-S cluster biosynthesis, and further support an allosteric regulator role for FXN.	Iron	98-102	frataxin	Homo sapiens	63-66
23102618-6	2012	Taken together, our data uncover a link between metabolic, inflammatory, and iron-regulatory pathways, and point toward the existence of a yeast-like TTP-mediated iron conservation program in mammals.	Iron	163-167	ZFP36 ring finger protein	Homo sapiens	150-153
24971490-8	2014	Together, these results lead to an activation model in which FXN accelerates persulfide formation on NFS1 and favors a helix-to-coil interconversion on ISCU2 that facilitates the transfer of sulfur from NFS1 to ISCU2 as an initial step in Fe-S cluster biosynthesis.	Iron	239-243	frataxin	Homo sapiens	61-64
23012475-0	2012	Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.	Iron	85-89	retinoid isomerohydrolase RPE65	Homo sapiens	13-18
23012475-6	2012	Complementary iron K-edge X-ray absorption spectroscopy data established that RPE65 as isolated contained a divalent iron center and demonstrated the presence of a tightly bound ligand consistent with a coordinated carboxylate group.	Iron	14-18	retinoid isomerohydrolase RPE65	Homo sapiens	78-83
24971490-8	2014	Together, these results lead to an activation model in which FXN accelerates persulfide formation on NFS1 and favors a helix-to-coil interconversion on ISCU2 that facilitates the transfer of sulfur from NFS1 to ISCU2 as an initial step in Fe-S cluster biosynthesis.	Iron	239-243	NFS1 cysteine desulfurase	Homo sapiens	101-105
23012475-6	2012	Complementary iron K-edge X-ray absorption spectroscopy data established that RPE65 as isolated contained a divalent iron center and demonstrated the presence of a tightly bound ligand consistent with a coordinated carboxylate group.	Iron	117-121	retinoid isomerohydrolase RPE65	Homo sapiens	78-83
22784867-2	2012	Modification (i.e. Fe immobilization on substrate) decreased the BET surface area and PZC of the original substrates while it increased the pore diameter and the cation exchange capacity (CEC) of them.	Iron	19-21	delta/notch like EGF repeat containing	Homo sapiens	65-68
24971490-8	2014	Together, these results lead to an activation model in which FXN accelerates persulfide formation on NFS1 and favors a helix-to-coil interconversion on ISCU2 that facilitates the transfer of sulfur from NFS1 to ISCU2 as an initial step in Fe-S cluster biosynthesis.	Iron	239-243	NFS1 cysteine desulfurase	Homo sapiens	203-207
22896707-6	2012	Furthermore we found two essential molecules for iron homeostasis, iron-sulfur cluster scaffold protein (ISCU) and transferrin receptor 1 (TfR), are a direct target of miR-210.	Iron	49-53	transferrin receptor	Homo sapiens	115-137
22896707-6	2012	Furthermore we found two essential molecules for iron homeostasis, iron-sulfur cluster scaffold protein (ISCU) and transferrin receptor 1 (TfR), are a direct target of miR-210.	Iron	49-53	transferrin receptor	Homo sapiens	139-142
24890018-6	2014	The anti-TFRC antibody blocked the interaction between transferrin and TFRC and consequently inhibited iron uptake, leading to the iron deprivation-mediated suppression of cell growth and induction of apoptosis.	Iron	103-107	transferrin receptor	Homo sapiens	9-13
22896707-6	2012	Furthermore we found two essential molecules for iron homeostasis, iron-sulfur cluster scaffold protein (ISCU) and transferrin receptor 1 (TfR), are a direct target of miR-210.	Iron	49-53	microRNA 210	Homo sapiens	168-175
22896707-9	2012	These findings suggest that miR-210 works as an iron sensor and is involved in the maintenance of iron homeostasis by sustaining the TfR expression level to stimulate cell proliferation and promote cell survival in the hypoxic region within tumors.	Iron	48-52	microRNA 210	Homo sapiens	28-35
22896707-9	2012	These findings suggest that miR-210 works as an iron sensor and is involved in the maintenance of iron homeostasis by sustaining the TfR expression level to stimulate cell proliferation and promote cell survival in the hypoxic region within tumors.	Iron	48-52	transferrin receptor	Homo sapiens	133-136
22896707-9	2012	These findings suggest that miR-210 works as an iron sensor and is involved in the maintenance of iron homeostasis by sustaining the TfR expression level to stimulate cell proliferation and promote cell survival in the hypoxic region within tumors.	Iron	98-102	microRNA 210	Homo sapiens	28-35
22896707-9	2012	These findings suggest that miR-210 works as an iron sensor and is involved in the maintenance of iron homeostasis by sustaining the TfR expression level to stimulate cell proliferation and promote cell survival in the hypoxic region within tumors.	Iron	98-102	transferrin receptor	Homo sapiens	133-136
22921191-0	2012	Improved survival with iron chelation therapy for red blood cell transfusion dependent lower IPSS risk MDS may be more significant in patients with a non-RARS diagnosis.	Iron	23-27	arginyl-tRNA synthetase 1	Homo sapiens	154-158
22968758-1	2012	Hybrid nanomaterials comprising tungsten heteropolyacid (HPW) and iron-based MOF Basolite  F 300 used as a support were obtained by post-synthesis combination of the two components.	Iron	66-70	lysine acetyltransferase 8	Homo sapiens	77-80
22898811-0	2012	ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.	Iron	11-15	solute carrier family 39 member 8	Homo sapiens	0-4
24890018-6	2014	The anti-TFRC antibody blocked the interaction between transferrin and TFRC and consequently inhibited iron uptake, leading to the iron deprivation-mediated suppression of cell growth and induction of apoptosis.	Iron	103-107	transferrin receptor	Homo sapiens	71-75
22898811-2	2012	Among the ZIP proteins, ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and cadmium.	Iron	83-87	solute carrier family 39 member 8	Homo sapiens	24-28
24890018-6	2014	The anti-TFRC antibody blocked the interaction between transferrin and TFRC and consequently inhibited iron uptake, leading to the iron deprivation-mediated suppression of cell growth and induction of apoptosis.	Iron	131-135	transferrin receptor	Homo sapiens	9-13
22898811-2	2012	Among the ZIP proteins, ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and cadmium.	Iron	83-87	solute carrier family 39 member 14	Homo sapiens	56-61
22898811-3	2012	Here we investigated the iron transport ability of ZIP8, its subcellular localization, pH dependence, and regulation by iron.	Iron	25-29	solute carrier family 39 member 8	Homo sapiens	51-55
23046549-10	2012	Body iron stores, as measured by ferritin, soluble transferrin receptor (sTfR) and the sTfR:ferritin ratio, were significantly associated with the risk of T2DM.	Iron	5-9	transferrin receptor	Homo sapiens	51-71
22898811-3	2012	Here we investigated the iron transport ability of ZIP8, its subcellular localization, pH dependence, and regulation by iron.	Iron	120-124	solute carrier family 39 member 8	Homo sapiens	51-55
24890018-6	2014	The anti-TFRC antibody blocked the interaction between transferrin and TFRC and consequently inhibited iron uptake, leading to the iron deprivation-mediated suppression of cell growth and induction of apoptosis.	Iron	131-135	transferrin receptor	Homo sapiens	71-75
22898811-4	2012	Transfection of HEK 293T cells with ZIP8 cDNA enhanced the uptake of (59)Fe and (65)Zn by 200 and 40%, respectively, compared with controls.	Iron	73-75	solute carrier family 39 member 8	Homo sapiens	36-40
24628561-9	2014	Microarray and quantitative RT-PCR analyses on the bone marrow stromal cells demonstrated remarkably reduced expression of CXCL12, VCAM-1, Kit-ligand, and IGF-1 in the iron-overloaded mice.	Iron	168-172	chemokine (C-X-C motif) ligand 12	Mus musculus	123-129
22898811-9	2012	Iron loading increased total and cell-surface levels of ZIP8 in H4IIE rat hepatoma cells.	Iron	0-4	solute carrier family 39 member 8	Rattus norvegicus	56-60
22898811-12	2012	Suppression of endogenous ZIP8 expression in BeWo cells, a placental cell line, reduced iron uptake by ~40%, suggesting that ZIP8 participates in placental iron transport.	Iron	88-92	solute carrier family 39 member 8	Homo sapiens	26-30
22898811-12	2012	Suppression of endogenous ZIP8 expression in BeWo cells, a placental cell line, reduced iron uptake by ~40%, suggesting that ZIP8 participates in placental iron transport.	Iron	88-92	solute carrier family 39 member 8	Homo sapiens	125-129
22898811-12	2012	Suppression of endogenous ZIP8 expression in BeWo cells, a placental cell line, reduced iron uptake by ~40%, suggesting that ZIP8 participates in placental iron transport.	Iron	156-160	solute carrier family 39 member 8	Homo sapiens	26-30
22898811-12	2012	Suppression of endogenous ZIP8 expression in BeWo cells, a placental cell line, reduced iron uptake by ~40%, suggesting that ZIP8 participates in placental iron transport.	Iron	156-160	solute carrier family 39 member 8	Homo sapiens	125-129
22898811-13	2012	Collectively, these data identify ZIP8 as an iron transport protein that may function in iron metabolism.	Iron	45-49	solute carrier family 39 member 8	Homo sapiens	34-38
23000401-0	2012	Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic beta cell fate in response to cytokines.	Iron	39-43	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-28
23000401-3	2012	Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1beta induces divalent metal transporter 1 (DMT1) expression correlating with increased beta cell iron content and ROS production.	Iron	198-202	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	114-142
23000401-3	2012	Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1beta induces divalent metal transporter 1 (DMT1) expression correlating with increased beta cell iron content and ROS production.	Iron	198-202	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	144-148
23000401-5	2012	Glucose-stimulated insulin secretion in the absence of cytokines in Dmt1 knockout islets is defective, highlighting a physiological role of iron and ROS in the regulation of insulin secretion.	Iron	140-144	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	68-72
22817335-3	2012	Investigating cell signalling pathway, we observed that iron (FeSO4) intoxication caused NF-kappaB activation as well as the phosphorylation of p38 and ERK MAPKs.	Iron	56-60	mitogen-activated protein kinase 14	Mus musculus	144-147
22855208-6	2012	This complex exhibits two irreversible reduction waves in solution at -30 mV versus NHE, corresponding to a ligand-based reduction, and at -385 mV versus NHE, corresponding to an irreversible Fe(3+)/Fe(2+) reduction of the Fe(L(PF))                            (3)                                      (6-)                          complex.	Iron	192-194	solute carrier family 9 member C1	Homo sapiens	84-87
24628561-9	2014	Microarray and quantitative RT-PCR analyses on the bone marrow stromal cells demonstrated remarkably reduced expression of CXCL12, VCAM-1, Kit-ligand, and IGF-1 in the iron-overloaded mice.	Iron	168-172	insulin-like growth factor 1	Mus musculus	155-160
22855208-6	2012	This complex exhibits two irreversible reduction waves in solution at -30 mV versus NHE, corresponding to a ligand-based reduction, and at -385 mV versus NHE, corresponding to an irreversible Fe(3+)/Fe(2+) reduction of the Fe(L(PF))                            (3)                                      (6-)                          complex.	Iron	192-194	solute carrier family 9 member C1	Homo sapiens	154-157
24749505-4	2014	FRDA is most commonly caused by an expanded GAA trinucleotide repeat in the first intron of FXN that leads to reduced levels of frataxin, a mitochondrial protein important for iron metabolism.	Iron	176-180	frataxin	Homo sapiens	0-4
23135603-3	2012	Particularly high peroxidase activity resulted in the up-regulation of genes encoding proteinase inhibitors, pathogenesis-related (PR) proteins, as well as proteins associated with iron and calcium transport, and flowering.	Iron	181-185	peroxidase	Solanum lycopersicum	18-28
23104832-4	2012	AE7 is part of a protein complex with CIA1, NAR1, and MET18, which are highly conserved in eukaryotes and are involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	162-166	ferredoxin hydrogenase	Arabidopsis thaliana	44-48
23104832-4	2012	AE7 is part of a protein complex with CIA1, NAR1, and MET18, which are highly conserved in eukaryotes and are involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	162-166	ARM repeat superfamily protein	Arabidopsis thaliana	54-59
24749505-4	2014	FRDA is most commonly caused by an expanded GAA trinucleotide repeat in the first intron of FXN that leads to reduced levels of frataxin, a mitochondrial protein important for iron metabolism.	Iron	176-180	alpha glucosidase	Homo sapiens	44-47
24749505-4	2014	FRDA is most commonly caused by an expanded GAA trinucleotide repeat in the first intron of FXN that leads to reduced levels of frataxin, a mitochondrial protein important for iron metabolism.	Iron	176-180	frataxin	Homo sapiens	92-95
22890853-1	2012	A reducible MIL-100(Fe) metal-organic framework (MOF) was investigated for the separation of a propane/propene mixture.	Iron	20-22	lysine acetyltransferase 8	Homo sapiens	24-53
24749505-4	2014	FRDA is most commonly caused by an expanded GAA trinucleotide repeat in the first intron of FXN that leads to reduced levels of frataxin, a mitochondrial protein important for iron metabolism.	Iron	176-180	frataxin	Homo sapiens	128-136
25002220-4	2014	The surface area and optical properties of the Fe-doped photocatalysts were measured by BET, UV and PL spectrometry and compared to non-graphene and pure TiO(2) analogs, showing a plateau at 0.6% Fe.	Iron	47-49	delta/notch like EGF repeat containing	Homo sapiens	88-91
22795587-1	2012	Zero-valent iron (Fe(0))-based permeable reactive barrier (PRB) technology has been proved to be effective for soil and groundwater nitrate remediation under acidic or near neutral conditions.	Iron	12-16	RB transcriptional corepressor 1	Homo sapiens	59-62
22795587-1	2012	Zero-valent iron (Fe(0))-based permeable reactive barrier (PRB) technology has been proved to be effective for soil and groundwater nitrate remediation under acidic or near neutral conditions.	Iron	18-23	RB transcriptional corepressor 1	Homo sapiens	59-62
22795587-10	2012	The results implied that PRB based Fe(0) is a potential approach for in situ remediation of soil and groundwater nitrate contamination in the alkaline conditions.	Iron	35-40	RB transcriptional corepressor 1	Homo sapiens	25-28
24988074-2	2014	Iron metabolism genes, such as the hemochromatosis (HFE) gene, have been reported to be modifiers for lead absorption and storage.	Iron	0-4	homeostatic iron regulator	Homo sapiens	52-55
22610083-4	2012	The identification of novel IREs involved in diverse cellular pathways has revealed that the IRP-IRE network extends to processes other than iron homeostasis.	Iron	141-145	Wnt family member 2	Homo sapiens	93-96
22610083-5	2012	A mechanistic understanding of IRP regulation will likely yield important insights into the basis of disorders of iron metabolism.	Iron	114-118	Wnt family member 2	Homo sapiens	31-34
24644245-3	2014	A molecular study of the genes involved in iron metabolism (HFE, HJV, HAMP, TFR2, SLC40A1) was undertaken.	Iron	43-47	homeostatic iron regulator	Homo sapiens	60-63
24937428-5	2014	The presence of LCN2 in urine was both necessary and sufficient to control the urinary tract infection through iron sequestration, even in the harsh condition of urine acidification.	Iron	111-115	lipocalin 2	Mus musculus	16-20
22915735-5	2012	Mice deficient of the c-Rel factor exhibited a marked immunoreactivity for fibrillary alpha-synuclein in the substantia nigra pars compacta as well as increased expression of divalent metal transporter 1 (DMT1) and iron staining in both the substantia nigra pars compacta and striatum.	Iron	215-219	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	205-209
22473803-5	2012	When fed a standard diet, Fpn1(Alb/Alb) mice showed mild hepatocyte iron retention.	Iron	68-72	albumin	Mus musculus	31-34
22473803-5	2012	When fed a standard diet, Fpn1(Alb/Alb) mice showed mild hepatocyte iron retention.	Iron	68-72	albumin	Mus musculus	35-38
22473803-7	2012	When fed an iron-deficient diet, Fpn1(Alb/Alb) mice showed impaired liver iron mobilization and anemia, with much lower RBC and Hb levels than Fpn1(flox/flox) mice on the same diet.	Iron	12-16	albumin	Mus musculus	38-41
22473803-7	2012	When fed an iron-deficient diet, Fpn1(Alb/Alb) mice showed impaired liver iron mobilization and anemia, with much lower RBC and Hb levels than Fpn1(flox/flox) mice on the same diet.	Iron	12-16	albumin	Mus musculus	42-45
22473803-9	2012	On a standard diet, Fpn1(Alb/Alb;LysM/LysM) mice displayed substantial iron retention in hepatocytes and macrophages, yet maintained intact erythropoiesis, implying a compensatory role for intestinal iron absorption.	Iron	71-75	albumin	Mus musculus	25-28
22473803-10	2012	In contrast, when Fpn1(Alb/Alb;LysM/LysM) mice were fed an iron-deficient diet, they developed severe iron-deficiency anemia, regardless of their iron storage status.	Iron	59-63	albumin	Mus musculus	23-26
22473803-10	2012	In contrast, when Fpn1(Alb/Alb;LysM/LysM) mice were fed an iron-deficient diet, they developed severe iron-deficiency anemia, regardless of their iron storage status.	Iron	102-106	albumin	Mus musculus	23-26
24777603-4	2014	bdh2 null mice developed microcytic anemia and tissue iron overload, especially in the spleen.	Iron	54-58	3-hydroxybutyrate dehydrogenase, type 2	Mus musculus	0-4
22473803-10	2012	In contrast, when Fpn1(Alb/Alb;LysM/LysM) mice were fed an iron-deficient diet, they developed severe iron-deficiency anemia, regardless of their iron storage status.	Iron	102-106	albumin	Mus musculus	27-30
24777603-5	2014	Exogenous supplementation with 2,5-DHBA alleviates splenic iron overload in bdh2 null mice.	Iron	59-63	3-hydroxybutyrate dehydrogenase, type 2	Mus musculus	76-80
24777603-6	2014	Additionally, bdh2 null mice exhibit reduced serum iron.	Iron	51-55	3-hydroxybutyrate dehydrogenase, type 2	Mus musculus	14-18
24860016-4	2014	We show that inactivating the exoribonuclease active site of Rrp44 up-regulates the iron uptake regulon.	Iron	84-88	exosome catalytic subunit DIS3	Saccharomyces cerevisiae S288C	61-66
24927598-7	2014	Asparagine-linked (N-linked) glycosylation of ZIP14, particularly the glycosylation at N102, was required for efficient membrane extraction of ZIP14 and therefore is necessary for its iron sensitivity.	Iron	184-188	solute carrier family 39 member 14	Homo sapiens	46-51
24927598-7	2014	Asparagine-linked (N-linked) glycosylation of ZIP14, particularly the glycosylation at N102, was required for efficient membrane extraction of ZIP14 and therefore is necessary for its iron sensitivity.	Iron	184-188	solute carrier family 39 member 14	Homo sapiens	143-148
24798325-0	2014	Bet v 1 from birch pollen is a lipocalin-like protein acting as allergen only when devoid of iron by promoting Th2 lymphocytes.	Iron	93-97	delta/notch like EGF repeat containing	Homo sapiens	0-3
24798325-5	2014	We demonstrate that similar to lipocalin 2, Bet v 1 is capable of binding iron via catechol-based siderophores.	Iron	74-78	delta/notch like EGF repeat containing	Homo sapiens	44-47
24798325-7	2014	Moreover, we give functional evidence of the immunomodulatory capacity of Bet v 1 being dependent on its iron-loaded state.	Iron	105-109	delta/notch like EGF repeat containing	Homo sapiens	74-77
24795345-5	2014	Notably, RAP-536 treatment mitigated disease complications of IE, including iron overload, splenomegaly, and bone pathology, while reducing erythropoietin levels, improving erythrocyte morphology, and extending erythrocyte life span.	Iron	76-80	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	9-12
24764049-3	2014	The present perspective highlights the importance of assessing the electrochemical behaviour of Li2(Fe,Mn)SiO4 by combining an arsenal of characterization techniques both spectroscopic and structural, in and ex situ.	Iron	100-102	ATP binding cassette subfamily A member 12	Homo sapiens	96-99
24798331-3	2014	The phenotypes due to overexpression of MMT1&amp;2 were similar to that seen in cells with deletions in MRS3 and MRS4, genes that encode the mitochondrial iron importers.	Iron	155-159	Mmt1p	Saccharomyces cerevisiae S288C	40-44
24798331-4	2014	Overexpression of MMT1&amp;2 resulted in induction of the low iron transcriptional response, similar to that seen in Deltamrs3Deltamr4 cells.	Iron	62-66	Mmt1p	Saccharomyces cerevisiae S288C	18-22
24798331-6	2014	Measurement of the activity of the iron-dependent gentisate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans expressed in yeast cytosol, showed that changes in Mmt1/2 levels affected cytosol iron concentration even in the absence of Ccc1.	Iron	35-39	Mmt1p	Saccharomyces cerevisiae S288C	166-172
24798331-6	2014	Measurement of the activity of the iron-dependent gentisate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans expressed in yeast cytosol, showed that changes in Mmt1/2 levels affected cytosol iron concentration even in the absence of Ccc1.	Iron	197-201	Mmt1p	Saccharomyces cerevisiae S288C	166-172
24798331-7	2014	Overexpression of MMT1 resulted in increased cytosolic iron whereas deletion of MMT1/MMT2 led to decreased cytosolic iron.	Iron	55-59	Mmt1p	Saccharomyces cerevisiae S288C	18-22
24798331-7	2014	Overexpression of MMT1 resulted in increased cytosolic iron whereas deletion of MMT1/MMT2 led to decreased cytosolic iron.	Iron	117-121	Mmt1p	Saccharomyces cerevisiae S288C	80-84
24798331-7	2014	Overexpression of MMT1 resulted in increased cytosolic iron whereas deletion of MMT1/MMT2 led to decreased cytosolic iron.	Iron	117-121	Mmt2p	Saccharomyces cerevisiae S288C	85-89
24798331-8	2014	These results support the hypothesis that Mmt1/2 function as mitochondrial iron exporters.	Iron	75-79	Mmt1p	Saccharomyces cerevisiae S288C	42-48
24833117-2	2014	Bulk chemical oxidation of 1 and 2 with Fc[PF6] (Fc = ferrocene) is accompanied by fluoride ion abstraction from PF6(-) by the iron center trans to the Fe NR functionality, forming F-Fe((i)PrNPPh2)3Fe NR ((i)Pr = isopropyl) (R = (t)Bu, 3; adamantyl, 4).	Iron	127-131	sperm associated antigen 17	Homo sapiens	43-46
24833117-2	2014	Bulk chemical oxidation of 1 and 2 with Fc[PF6] (Fc = ferrocene) is accompanied by fluoride ion abstraction from PF6(-) by the iron center trans to the Fe NR functionality, forming F-Fe((i)PrNPPh2)3Fe NR ((i)Pr = isopropyl) (R = (t)Bu, 3; adamantyl, 4).	Iron	127-131	sperm associated antigen 17	Homo sapiens	113-116
24833117-2	2014	Bulk chemical oxidation of 1 and 2 with Fc[PF6] (Fc = ferrocene) is accompanied by fluoride ion abstraction from PF6(-) by the iron center trans to the Fe NR functionality, forming F-Fe((i)PrNPPh2)3Fe NR ((i)Pr = isopropyl) (R = (t)Bu, 3; adamantyl, 4).	Iron	152-154	sperm associated antigen 17	Homo sapiens	43-46
24833117-2	2014	Bulk chemical oxidation of 1 and 2 with Fc[PF6] (Fc = ferrocene) is accompanied by fluoride ion abstraction from PF6(-) by the iron center trans to the Fe NR functionality, forming F-Fe((i)PrNPPh2)3Fe NR ((i)Pr = isopropyl) (R = (t)Bu, 3; adamantyl, 4).	Iron	152-154	sperm associated antigen 17	Homo sapiens	113-116
24833117-2	2014	Bulk chemical oxidation of 1 and 2 with Fc[PF6] (Fc = ferrocene) is accompanied by fluoride ion abstraction from PF6(-) by the iron center trans to the Fe NR functionality, forming F-Fe((i)PrNPPh2)3Fe NR ((i)Pr = isopropyl) (R = (t)Bu, 3; adamantyl, 4).	Iron	183-185	sperm associated antigen 17	Homo sapiens	43-46
24833117-2	2014	Bulk chemical oxidation of 1 and 2 with Fc[PF6] (Fc = ferrocene) is accompanied by fluoride ion abstraction from PF6(-) by the iron center trans to the Fe NR functionality, forming F-Fe((i)PrNPPh2)3Fe NR ((i)Pr = isopropyl) (R = (t)Bu, 3; adamantyl, 4).	Iron	183-185	sperm associated antigen 17	Homo sapiens	113-116
24699828-10	2014	DMT1 showed a lower expression in the two iron groups compared with control and diabetic animals, and Hpc showed an increased on its expression in Fe and diabetic/Fe groups.	Iron	42-46	solute carrier family 11 member 2	Sus scrofa	0-4
24245804-9	2014	Collectively, our data suggest that viperin requires CIAO1 for [4Fe-4S] cluster assembly, and acts through an enzymatic, Fe-S cluster- and SAM-dependent mechanism to inhibit viral RNA synthesis.	Iron	121-125	radical S-adenosyl methionine domain containing 2	Homo sapiens	36-43
23298506-6	2012	Our study suggests that iron status parameters, in particular serum iron, ferritin, sTfR and TfR index, could be useful tools for the early detection and the diagnosis of orthopaedic prosthetic joint infections.	Iron	24-28	transferrin receptor	Homo sapiens	85-88
24536049-7	2014	Heme iron was positively associated with colorectal cancer among those with GG genotypes for ACO1 rs10970985 (ORQ4-Q 1 = 2.45, 95% CI 3.40-8.06, Ptrend = 0.004; Pinteraction = 0.05).	Iron	5-9	aconitase 1	Homo sapiens	93-97
22955522-0	2012	Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by systems-theoretical analysis.	Iron	136-140	parathyroid hormone like hormone	Homo sapiens	10-15
22955522-3	2012	We proposed inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network.	Iron	148-152	parathyroid hormone like hormone	Homo sapiens	22-27
22955522-5	2012	Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, ALK, CIAO1, NOTCH3 in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference method and our programming.	Iron	136-140	parathyroid hormone like hormone	Homo sapiens	10-15
22237814-9	2012	RESULTS: FAC and FeCi exposure modulated cellular iron status with a decrease in TFRC mRNA level and an increase in intracellular ferritin level.	Iron	50-54	transferrin receptor	Homo sapiens	81-85
24966834-3	2014	Matriptase-2 was later established to be essential in iron homeostasis based on the phenotypes of iron-refractory iron deficiency anemia identified in mouse models as well as in human patients with TMPRSS6 mutations.	Iron	54-58	transmembrane serine protease 6	Mus musculus	0-12
22897349-1	2012	The progressive neurodegenerative disease Friedreich"s ataxia is caused by a decreased level of expression of frataxin, a putative iron chaperone.	Iron	131-135	frataxin	Homo sapiens	110-118
22897349-2	2012	Frataxin is thought to transiently interact with ISU, the scaffold protein onto which iron-sulfur clusters are assembled, to deliver ferrous iron.	Iron	86-90	frataxin	Homo sapiens	0-8
22897349-3	2012	Photoreactive heterotrifunctional chemical cross-linking confirmed the interaction between frataxin and ISU in the presence of iron and validated that transient interactions can be covalently trapped with this method.	Iron	127-131	frataxin	Homo sapiens	91-99
24847265-1	2014	Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer TFR1, is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1.	Iron	64-68	transferrin receptor	Mus musculus	78-82
22764179-3	2012	Frataxin is an iron-binding protein targeted to the mitochondrial matrix.	Iron	15-19	frataxin	Homo sapiens	0-8
24847265-6	2014	The iron deficient Tfr2-Tmprss6 double knock out mice have higher red cells count and more severe microcytosis than the liver-specific Tfr2 and Tmprss6 double knock out mice.	Iron	4-8	transmembrane serine protease 6	Mus musculus	24-31
24429875-2	2014	The yeast ortholog of the human frataxin, a mitochondrial protein essential for iron homeostasis and responsible for Friedreich"s ataxia, has been shown to undergo cold denaturation above 0  C, in the absence of chemical denaturants.	Iron	80-84	frataxin	Homo sapiens	32-40
24725620-13	2014	Cell and animal models suggest a potential role of titin degradation in iron overload-induced alteration of LV torsional mechanics.	Iron	72-76	titin	Homo sapiens	51-56
22791549-2	2012	Friedreich ataxia is caused by the decreased expression and/or function of frataxin, a mitochondrial matrix protein that binds iron and is involved in the formation of iron-sulfur clusters.	Iron	127-131	frataxin	Homo sapiens	75-83
22791549-2	2012	Friedreich ataxia is caused by the decreased expression and/or function of frataxin, a mitochondrial matrix protein that binds iron and is involved in the formation of iron-sulfur clusters.	Iron	168-172	frataxin	Homo sapiens	75-83
22791549-3	2012	Decreased frataxin function leads to decreased iron-sulfur cluster formation, mitochondrial iron accumulation, cytosolic iron depletion, oxidative stress, and mitochondrial dysfunction.	Iron	92-96	frataxin	Homo sapiens	10-18
22791549-3	2012	Decreased frataxin function leads to decreased iron-sulfur cluster formation, mitochondrial iron accumulation, cytosolic iron depletion, oxidative stress, and mitochondrial dysfunction.	Iron	92-96	frataxin	Homo sapiens	10-18
25152881-11	2014	The proposed FE model has been implemented in the FE code Abaqus (UMAT routine).	Iron	13-15	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	66-70
22859693-4	2012	Mutations in the frataxin gene impair mitochondrial function, increase reactive oxygen species, and trigger redistribution of iron in the mitochondria and cytosol.	Iron	126-130	frataxin	Homo sapiens	17-25
23156707-5	2012	Given that controlled experiments with sufficient numbers of rhinoceros are logistically not possible, an equine model was used to look for a relationship between iron status and insulin resistance; the nutritional requirements of horses are used as a guide for rhinoceros, because they have similar gastrointestinal tracts.	Iron	163-167	INS	Equus caballus	179-186
23156707-13	2012	These data suggest a potential link between insulin resistance and body stores of iron and also suggest that approaches to reduce the susceptibility to insulin resistance should be incorporated into management of captive browsing rhinoceros.	Iron	82-86	INS	Equus caballus	44-51
25152881-11	2014	The proposed FE model has been implemented in the FE code Abaqus (UMAT routine).	Iron	50-52	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	66-70
22434419-5	2012	Blocking holo-Tf binding with an anti-TfR antibody significantly decreases the reduction of iron from transferrin by hBMVEC, suggesting that holo-Tf needs to bind to TfR in order for efficient reduction to occur.	Iron	92-96	transferrin receptor	Homo sapiens	38-41
25755436-15	2012	CONCLUSIONS: The literature shows discordant results about the prevalence, hepatic distribution and possible therapeutic implications of iron overload in chronic hepatitis C. Our findings shows that HFE gene mutations could favor, synergically with CHC and other genetic or acquired factors, the development of liver damage and could influence the outcome of interferon treatment with higher rate of non-response.	Iron	137-141	homeostatic iron regulator	Homo sapiens	199-202
24706911-4	2014	The structures reveal PhnZ to have an active site containing two Fe ions coordinated by four histidines and two aspartates that is strikingly similar to the carbon-carbon bond cleaving enzyme, myo-inositol-oxygenase.	Iron	65-67	myo-inositol oxygenase	Homo sapiens	193-215
22511606-7	2012	Results suggest that AtFH plays an important role in the early steps of Fe-S cluster formation by regulating AtNfs1 activity in plant mitochondria.	Iron	72-76	frataxin-like protein	Arabidopsis thaliana	21-25
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	147-151	lipocalin 2	Mus musculus	43-54
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	147-151	lipocalin 2	Mus musculus	56-60
24138602-2	2014	Frataxin, a mitochondrial matrix protein, has been identified as playing a key role in the iron metabolism of this organelle due to its iron-binding properties and is known to be essential for iron-sulphur cluster formation.	Iron	91-95	frataxin	Homo sapiens	0-8
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	194-198	lipocalin 2	Mus musculus	43-54
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	194-198	lipocalin 2	Mus musculus	56-60
22526559-5	2012	In the past 5 years we have begun to show a relationship between polymorphisms in the HFE (high iron) gene and the risk of neurodegenerative disorders.	Iron	96-100	homeostatic iron regulator	Homo sapiens	86-89
21514009-2	2012	In this context, hemochromatosis (Hfe) and transferrin (Tf) genes are of particular importance, since they play a key role in iron homeostasis.	Iron	126-130	homeostatic iron regulator	Homo sapiens	34-37
22684504-0	2012	Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domain.	Iron	86-90	bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2	Saccharomyces cerevisiae S288C	59-63
22684504-2	2012	Yeast Dna2 protein contains a conserved putative Fe-S (iron-sulfur) cluster signature motif spanning the nuclease active site.	Iron	49-53	bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2	Saccharomyces cerevisiae S288C	6-10
22684504-2	2012	Yeast Dna2 protein contains a conserved putative Fe-S (iron-sulfur) cluster signature motif spanning the nuclease active site.	Iron	55-59	bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2	Saccharomyces cerevisiae S288C	6-10
22318508-3	2012	Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, manganese, and cadmium.	Iron	193-197	solute carrier family 39 member 14	Homo sapiens	73-78
22318508-3	2012	Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, manganese, and cadmium.	Iron	193-197	solute carrier family 39 member 8	Homo sapiens	83-87
22476617-10	2012	3T3-L1 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 showed increased NF-kappaB mRNA expression and decreased Mfn-2 expression in all experimental conditions.	Iron	35-37	mitofusin 2	Mus musculus	140-145
21514009-10	2012	Our results suggest the existence of a link between Hfe mutations and iron abnormalities that increases the probability of developing AD when accompanied by a distress of the liver.	Iron	70-74	homeostatic iron regulator	Homo sapiens	52-55
24138602-2	2014	Frataxin, a mitochondrial matrix protein, has been identified as playing a key role in the iron metabolism of this organelle due to its iron-binding properties and is known to be essential for iron-sulphur cluster formation.	Iron	136-140	frataxin	Homo sapiens	0-8
24138602-2	2014	Frataxin, a mitochondrial matrix protein, has been identified as playing a key role in the iron metabolism of this organelle due to its iron-binding properties and is known to be essential for iron-sulphur cluster formation.	Iron	136-140	frataxin	Homo sapiens	0-8
24138602-4	2014	The decrease in frataxin expression, as seen in the inherited disorder Friedreich"s ataxia, markedly alters cellular and mitochondrial iron metabolism in both the mitochondrion and the cell.	Iron	135-139	frataxin	Homo sapiens	16-24
24138602-7	2014	Unravelling the mechanisms of altered iron metabolism in Friedreich"s ataxia will help elucidate a biochemical function for frataxin.	Iron	38-42	frataxin	Homo sapiens	124-132
22504868-1	2012	Mutations in the haemochromatosis gene (HFE) influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis.	Iron	55-59	homeostatic iron regulator	Homo sapiens	40-43
22565018-1	2012	Hepcidin, an antimicrobial peptide, has a dual function including innate immunity and iron regulation.	Iron	86-90	hepcidin	Cynoglossus semilaevis	0-8
22565018-11	2012	Further exploration to elucidate the role of CsHepcidin in iron regulation and embryogenesis in C. semilaevis are needed.	Iron	59-63	hepcidin	Cynoglossus semilaevis	45-55
22504868-1	2012	Mutations in the haemochromatosis gene (HFE) influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis.	Iron	124-128	homeostatic iron regulator	Homo sapiens	40-43
24138602-9	2014	This review will focus on the emerging function of frataxin in relation to the observed alterations in mitochondrial iron metabolism in Friedreich"s ataxia.	Iron	117-121	frataxin	Homo sapiens	51-59
24729993-1	2014	BACKGROUND: Previous research has suggested that the H63D HFE mutation is associated with elevated iron indexes.	Iron	99-103	homeostatic iron regulator	Homo sapiens	58-61
22499213-6	2012	Lcn2 is a multi-functional protein that plays a role in glial activation, matrix metalloproteinase (MMP) stabilization, and cellular iron flux.	Iron	133-137	lipocalin 2	Mus musculus	0-4
22367974-5	2012	To circumvent these confounds, we developed transgenic mice that express tetracycline transactivator regulated, dominant negative transferrin receptor (DNTfR1) in hippocampal neurons, disrupting TfR1 mediated iron uptake specifically in CA1 pyramidal neurons.	Iron	209-213	transferrin receptor	Mus musculus	130-150
22367974-5	2012	To circumvent these confounds, we developed transgenic mice that express tetracycline transactivator regulated, dominant negative transferrin receptor (DNTfR1) in hippocampal neurons, disrupting TfR1 mediated iron uptake specifically in CA1 pyramidal neurons.	Iron	209-213	transferrin receptor	Mus musculus	154-158
22367974-11	2012	Together, these findings demonstrate that hippocampal iron availability is necessary between P21 and P42 for development of normal spatial learning and memory, and that these effects may reflect disruption of critical period closure by early life ID.	Iron	54-58	cyclin-dependent kinase 20	Mus musculus	101-104
23755843-4	2014	METHOD: We used the Long Evans Cinnamon (LEC) rat, which onsets severe hepatitis and high incidence of liver cancer, due to the accumulation of copper and iron in livers caused by the genetic mutation in Atp7B gene, and leading to the continuous oxidative stress.	Iron	155-159	ATPase copper transporting beta	Rattus norvegicus	204-209
22634399-2	2012	We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy.	Iron	166-170	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	31-59
22634399-2	2012	We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy.	Iron	166-170	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	61-65
22634399-2	2012	We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy.	Iron	166-170	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	137-141
22634399-2	2012	We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy.	Iron	166-170	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	137-141
22510500-4	2012	Iron loading is usually only mild or moderate in degree [less than that associated with full-blown haemochromatosis (HFE)] and is usually acquired and/or mutations in HFE.	Iron	0-4	homeostatic iron regulator	Homo sapiens	117-120
22510500-4	2012	Iron loading is usually only mild or moderate in degree [less than that associated with full-blown haemochromatosis (HFE)] and is usually acquired and/or mutations in HFE.	Iron	0-4	homeostatic iron regulator	Homo sapiens	167-170
22544036-1	2012	Iron regulatory protein 1 (IRP-1) is a bifunctional protein involved in iron homeostasis and metabolism.	Iron	72-76	aconitase 1	Homo sapiens	0-25
22544036-1	2012	Iron regulatory protein 1 (IRP-1) is a bifunctional protein involved in iron homeostasis and metabolism.	Iron	72-76	aconitase 1	Homo sapiens	27-32
22768841-6	2012	Toxicity is mediated by sphingolipid signaling, as inactivation of the sphingolipid-activated protein kinases Pkh1p and Ypk1p and of the transcription factor Smp1p also enhances resistance to high iron conditions.	Iron	197-201	serine/threonine protein kinase YPK1	Saccharomyces cerevisiae S288C	120-125
24321703-2	2014	Genetic iron overload has long been confined to the classical type 1 hemochromatosis related to the HFE C282Y mutation.	Iron	8-12	homeostatic iron regulator	Homo sapiens	100-103
22555879-7	2012	The shoot and root growth of atx1 and cchatx1 but not cch was specifically hypersensitive to excess Cu but not excess iron, zinc, or cadmium.	Iron	118-122	homolog of anti-oxidant 1	Arabidopsis thaliana	29-33
24549117-9	2014	The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl.	Iron	19-23	ferric reduction oxidase 2	Arabidopsis thaliana	52-56
22658601-6	2012	We further show that BTBD9 regulates brain dopamine levels in flies and controls iron homeostasis through the iron regulatory protein-2 in human cell lines.	Iron	81-85	BTB domain containing 9	Homo sapiens	21-26
22486465-1	2012	Using industrial titanyl sulfate as a raw material, Fe-doped sulfated titania (FST) photocatalysts were prepared by using the one-step thermal hydrolysis method and characterized using XRD, SEM, TGA-DSC, FTIR, UV-Vis DRS and N(2)  adsorption-desorption techniques.	Iron	52-54	T-box transcription factor 1	Homo sapiens	195-198
24390086-1	2014	Pirin, a product of the PIR gene, is an iron-binding protein acting as a transcriptional coregulator implicated in the regulation of the NF-kappaB-related transcription via interaction with RelA (p65), as well as BCL3 and NF-kappaB1 (p50) proteins.	Iron	40-44	RELA proto-oncogene, NF-kB subunit	Homo sapiens	196-199
22595555-2	2012	Fe-Ag bimetallic nano-particles were synthesized by reductive deposition of Ag on nano-iron and characterized with a number of techniques, including BET, XRD, TEM and XPS.	Iron	0-2	delta/notch like EGF repeat containing	Homo sapiens	149-152
22496346-6	2012	The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules.	Iron	56-60	transferrin receptor	Mus musculus	110-130
22496346-6	2012	The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules.	Iron	56-60	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	136-184
22496346-6	2012	The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules.	Iron	251-255	transferrin receptor	Mus musculus	110-130
22496346-6	2012	The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules.	Iron	251-255	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	136-184
22573324-3	2012	A membrane-extrinsic catalytic domain composed of the Sdh1p and Sdh2p subunits harbors the flavin and iron-sulfur cluster cofactors.	Iron	102-106	succinate dehydrogenase flavoprotein subunit SDH1	Saccharomyces cerevisiae S288C	54-59
24365882-10	2014	In contrast, a decreased TfR1 level was detected by IL-6 and iron alone, whereas combination of iron and AP cytokines (mainly IL-6) abrogated the downregulation of TfR1.	Iron	96-100	transferrin receptor	Rattus norvegicus	164-168
22573324-3	2012	A membrane-extrinsic catalytic domain composed of the Sdh1p and Sdh2p subunits harbors the flavin and iron-sulfur cluster cofactors.	Iron	102-106	succinate dehydrogenase iron-sulfur protein subunit SDH2	Saccharomyces cerevisiae S288C	64-69
22554902-10	2012	Taken together, our results indicate that the hlyA and hlyI genes of P. intermedia encode putative hemolysins that appear to be involved in the lysis of red blood cells, and suggest that these hemolysins might play important roles in the iron-dependent growth of this organism.	Iron	238-242	hemolysin transport protein	Escherichia coli	46-50
24365882-11	2014	An increase in LCN-2 release into the supernatant of cultured hepatocytes was observed after addition of iron/AP cytokines into the medium.	Iron	105-109	lipocalin 2	Rattus norvegicus	15-20
22689995-0	2012	Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold.	Iron	71-75	NFS1 cysteine desulfurase	Homo sapiens	21-25
24509859-6	2014	IRP1 attenuates protoporphyrin biosynthesis by binding to the 5"-iron response element (IRE) of alas2 mRNA, inhibiting its translation.	Iron	65-69	aconitase 1	Homo sapiens	0-4
21397666-3	2012	SCOPE OF REVIEW: The principles by which mitochondrial SNO proteins are formed and their actions, independently or collectively with NO binding to heme, iron-sulfur centers, or to glutathione (GSH) are reviewed on a molecular background of SNO-based signal transduction.	Iron	153-157	strawberry notch homolog 1	Homo sapiens	55-58
22016365-9	2012	Such responses are mediated by a number of iron-sensitive signalling pathways, including the IRE/IRP system, HIF and haem signalling.	Iron	43-47	Wnt family member 2	Homo sapiens	97-100
24509859-6	2014	IRP1 attenuates protoporphyrin biosynthesis by binding to the 5"-iron response element (IRE) of alas2 mRNA, inhibiting its translation.	Iron	65-69	5'-aminolevulinate synthase 2	Homo sapiens	96-101
22399236-1	2012	Frataxin (FXN) is a mitochondrial protein involved in iron metabolism and in the modulation of reactive oxygen and/or nitrogen species production.	Iron	54-58	frataxin	Homo sapiens	0-8
24604199-1	2014	The yeast mitochondrial ABC transporter Atm1, in concert with glutathione, functions in the export of a substrate required for cytosolic-nuclear iron-sulfur protein biogenesis and cellular iron regulation.	Iron	145-149	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	40-44
22399236-1	2012	Frataxin (FXN) is a mitochondrial protein involved in iron metabolism and in the modulation of reactive oxygen and/or nitrogen species production.	Iron	54-58	frataxin	Homo sapiens	10-13
22098610-0	2012	Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C. BACKGROUND AND AIM: HFE mutations, a common cause of hereditary hemochromatosis (HH), are reportedly associated with hepatic iron overload, severe liver fibrosis, and good response to interferon treatment in European patients with chronic hepatitis C (CHC).	Iron	205-209	homeostatic iron regulator	Homo sapiens	19-22
22098610-0	2012	Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C. BACKGROUND AND AIM: HFE mutations, a common cause of hereditary hemochromatosis (HH), are reportedly associated with hepatic iron overload, severe liver fibrosis, and good response to interferon treatment in European patients with chronic hepatitis C (CHC).	Iron	205-209	homeostatic iron regulator	Homo sapiens	100-103
22404220-4	2012	Nevertheless, the role of TTCC as well as other transporters such as divalent metal transporter1 (DMT1) and L-type calcium channels (LTCC) as possible portals for iron entry into the heart in in vivo thalassemic mice under an iron-overload condition has not been investigated.	Iron	163-167	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	69-96
22404220-4	2012	Nevertheless, the role of TTCC as well as other transporters such as divalent metal transporter1 (DMT1) and L-type calcium channels (LTCC) as possible portals for iron entry into the heart in in vivo thalassemic mice under an iron-overload condition has not been investigated.	Iron	163-167	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	98-102
22183642-1	2012	UNLABELLED: Hemochromatosis is considered by many to be an uncommon disorder, although the prevalence of HFE (High Iron) 282 Cys   Tyr (C282Y) homozygosity is relatively high in Caucasians.	Iron	115-119	homeostatic iron regulator	Homo sapiens	105-108
22718642-12	2012	H63D mutations in the HFE gene may cause higher levels of serum iron and transferrin saturation.	Iron	64-68	homeostatic iron regulator	Homo sapiens	22-25
24414856-5	2014	The zebrafish model of iron overload described in this study demonstrated an apparent inhibition of bone formation, accompanied by decreased expression of osteoblast-specific genes (runx2a, runx2b, osteocalcin, osteopontin, ALP, and collagen type I).	Iron	23-27	RUNX family transcription factor 2a	Danio rerio	182-188
22490684-4	2012	Here, we show that homozygous loss of Tmprss6 in Hbb(th3/+) mice improves anemia and reduces ineffective erythropoiesis, splenomegaly, and iron loading.	Iron	139-143	transmembrane serine protease 6	Mus musculus	38-45
22490684-8	2012	Our study indicates that preventing iron overload improves beta-thalassemia and strengthens the essential role of Tmprss6 for Hamp suppression, providing a proof of concept that Tmprss6 manipulation can offer a novel therapeutic option in this condition.	Iron	36-40	transmembrane serine protease 6	Mus musculus	178-185
22704260-0	2012	C19orf12 and FA2H mutations are rare in Italian patients with neurodegeneration with brain iron accumulation.	Iron	91-95	fatty acid 2-hydroxylase	Homo sapiens	13-17
22586079-5	2012	Current models of IRE-mRNA regulation, emphasizing iron-dependent degradation/modification of IRP, lack answers about how iron increases IRE-RNA/IRP protein dissociation or how IRE-RNA, after IRP dissociation, influences protein synthesis rates.	Iron	122-126	Wnt family member 2	Homo sapiens	145-148
22586079-5	2012	Current models of IRE-mRNA regulation, emphasizing iron-dependent degradation/modification of IRP, lack answers about how iron increases IRE-RNA/IRP protein dissociation or how IRE-RNA, after IRP dissociation, influences protein synthesis rates.	Iron	122-126	Wnt family member 2	Homo sapiens	145-148
22586079-8	2012	The regulation by metabolic iron binding to IRE-RNA to decrease inhibitor protein (IRP) binding and increase activator protein (eIF4F) binding identifies IRE-RNA as a riboregulator.	Iron	28-32	Wnt family member 2	Homo sapiens	83-86
24414856-5	2014	The zebrafish model of iron overload described in this study demonstrated an apparent inhibition of bone formation, accompanied by decreased expression of osteoblast-specific genes (runx2a, runx2b, osteocalcin, osteopontin, ALP, and collagen type I).	Iron	23-27	secreted phosphoprotein 1	Danio rerio	211-222
23775519-1	2014	UNLABELLED: Defects in human hemochromatosis protein (HFE) cause iron overload due to reduced hepatic hepcidin secretion.	Iron	65-69	homeostatic iron regulator	Homo sapiens	54-57
22297268-1	2012	The ultrafast photo-induced primary processes of the iron-(III) azido complex, [Fe(III)N(3)(cyclam-acetato)] PF(6) (1), in acetonitrile solution at room temperature were studied using femtosecond spectroscopy with ultraviolet (UV) excitation and mid-infrared (MIR) detection.	Iron	53-57	sperm associated antigen 17	Homo sapiens	109-114
24574363-4	2014	CONCLUSION: HFE-HH is an autosomal recessive disorder and two major genes C282Y and H63D are associated with HH (iron overload) susceptibility particularly C282Y/C282Y mutations.	Iron	113-117	homeostatic iron regulator	Homo sapiens	12-15
22565179-2	2012	HFE-related hemochromatosis (HFE hemochromatosis) or type 1 hemochromatosis is an autosomal recessive disease characterized by progressive iron overload usually expressed in adulthood.	Iron	139-143	homeostatic iron regulator	Homo sapiens	0-3
22565179-3	2012	The HFE gene, located on the short arm of chromosome 6 (6p21.3), encodes a protein that plays a crucial role in iron metabolism by modulating hepcidin synthesis in the liver.	Iron	112-116	homeostatic iron regulator	Homo sapiens	4-7
22180422-9	2012	However, fetuses of Hfe-knockout mothers showed further elevation of liver iron levels, concomitant with elevated expression of Tfr1, Dmt1 and Fpn in the placenta.	Iron	75-79	homeostatic iron regulator	Homo sapiens	20-23
24574363-6	2014	Individuals who develop iron overload may develop broad symptoms, including joint discomfort, fatigue, decreased libido, and abdominal pain; and if left untreated, HFE-HH has the potential of developing end-organ disease including liver fibrosis, cirrhosis, and cancer; cardiac arrhythmias or heart failure; and diabetes.	Iron	24-28	homeostatic iron regulator	Homo sapiens	164-167
22180422-10	2012	Hfe-knockout fetuses that express low levels of liver hepcidin accumulated more iron in their liver than wild-type fetuses due to increased ferroportin levels in the placenta.	Iron	80-84	homeostatic iron regulator	Homo sapiens	0-3
24804175-3	2014	The inherited predisposition to excessive absorption of dietary iron in HH is almost always the result of homozygosity of the C282Y mutation of the HFE gene, which causes inappropriately low secretion of hepcidin.	Iron	64-68	homeostatic iron regulator	Homo sapiens	148-151
22180422-12	2012	Maternal Hfe regulates iron transfer by altering gene expression in the placenta.	Iron	23-27	homeostatic iron regulator	Homo sapiens	9-12
22180422-13	2012	Fetal Hfe is important in regulating placental iron transfer by modulating fetal liver hepcidin expression.	Iron	47-51	homeostatic iron regulator	Homo sapiens	6-9
24435655-3	2014	CD71 has a physiological role in cellular iron intake and is implicated in the carcinogenesis of various types of tumors.	Iron	42-46	transferrin receptor	Homo sapiens	0-4
31130817-5	2012	The conversion of iron to iron oxide in aqueous solution with air oxidation was studied based on X-ray diffraction, Mossbauer spectroscopy and BET surface area test methods.	Iron	18-22	delta/notch like EGF repeat containing	Homo sapiens	143-146
22342521-1	2012	Hephaestin (Heph) is a ferroxidase protein that converts ferrous to ferric iron to facilitate cellular iron export by ferroportin.	Iron	75-79	hephaestin	Mus musculus	0-4
24596241-5	2014	The absence of SNX led to reduced iron import efficiency into the root.	Iron	34-38	sorting nexin	Arabidopsis thaliana	15-18
22342521-3	2012	In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear.	Iron	114-118	hephaestin	Mus musculus	41-45
22342521-3	2012	In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear.	Iron	114-118	hephaestin	Mus musculus	84-88
22342521-5	2012	Loss of both Heph and Cp from RPE cells alone results in RPE cell iron accumulation and degeneration.	Iron	66-70	hephaestin	Mus musculus	13-17
22342521-7	2012	Photoreceptor-specific Heph knockout indicates that the additional iron in the RPE cells does not result from loss of ferroxidases in the photoreceptors, and Cp and Heph play minor roles in photoreceptors.	Iron	67-71	hephaestin	Mus musculus	23-27
22342521-9	2012	Cp and Heph are necessary for iron export from the retina but are not essential for iron import into the retina.	Iron	30-34	hephaestin	Mus musculus	7-11
21947861-6	2012	This study indicated that DMT1 is likely involved in endosomal iron transport in placental STB and placental DMT1 + IRE expression was primarily regulated by the IRE/IRP mechanism.	Iron	63-67	Wnt family member 2	Homo sapiens	166-169
24596241-9	2014	snx mutants exhibited enhanced iron deficiency responses compared with the wild type, presumably due to the lower iron uptake through IRT1.	Iron	31-35	sorting nexin	Arabidopsis thaliana	0-3
24586648-4	2014	FACS analysis showed an increase in the labile iron pool, enhanced reactive oxygen species formation and mitochondrial depolarization.	Iron	47-51	acyl-CoA synthetase long-chain family member 1	Mus musculus	0-4
22171070-0	2012	HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis.	Iron	84-88	frataxin	Homo sapiens	21-29
22171070-1	2012	Friedreich"s ataxia is a neurodegenerative disorder caused by mutations in the frataxin gene that produces a predominantly mitochondrial protein whose primary function appears to be mitochondrial iron-sulfur cluster (ISC) biosynthesis.	Iron	196-200	frataxin	Homo sapiens	79-87
22171070-9	2012	These results indicate that HSC20 interacts with frataxin structurally and functionally and is important for ISC biogenesis and iron homeostasis in mammals.	Iron	128-132	frataxin	Homo sapiens	49-57
24236640-1	2014	ATOH8 has previously been shown to be an iron-regulated transcription factor, however its role in iron metabolism is not known.	Iron	41-45	atonal bHLH transcription factor 8	Homo sapiens	0-5
22538662-1	2012	The ferrophilic bacterium Vibrio vulnificus can utilize the siderophore aerobactin of Escherichia coli for iron acquisition via its specific receptor IutA.	Iron	107-111	Aerobactin siderophore ferric receptor protein IutA	Escherichia coli	150-154
24236640-1	2014	ATOH8 has previously been shown to be an iron-regulated transcription factor, however its role in iron metabolism is not known.	Iron	98-102	atonal bHLH transcription factor 8	Homo sapiens	0-5
24236640-6	2014	Hepatic Atoh8 mRNA levels increased in mice treated with holo transferrin, suggesting that Atoh8 responds to changes in plasma iron.	Iron	127-131	atonal bHLH transcription factor 8	Mus musculus	8-13
24236640-6	2014	Hepatic Atoh8 mRNA levels increased in mice treated with holo transferrin, suggesting that Atoh8 responds to changes in plasma iron.	Iron	127-131	atonal bHLH transcription factor 8	Mus musculus	91-96
22393021-4	2012	We report that RelA, a protein long known as the central regulator of the bacterial-stringent response, acts on Hfq and thereby affects the physiological activity of RyhB sRNA as a regulator of iron homeostasis.	Iron	194-198	RELA proto-oncogene, NF-kB subunit	Homo sapiens	15-19
24236640-7	2014	ATOH8 is therefore a novel transcriptional regulator of HAMP, which is responsive to changes in plasma iron and erythroid activity and could explain how changes in erythroid activity lead to regulation of HAMP.	Iron	103-107	atonal bHLH transcription factor 8	Homo sapiens	0-5
22393021-5	2012	RyhB requires RelA in vivo to arrest growth during iron depletion and to down-regulate a subset of its target mRNAs (fdoG, nuoA, and sodA), whereas the sodB and sdhC targets are barely affected by RelA.	Iron	51-55	RELA proto-oncogene, NF-kB subunit	Homo sapiens	14-18
24475238-5	2014	Here we show that loss of Ndfip1 from mouse dopaminergic neurons resulted in misregulation of DMT1 levels and increased susceptibility to iron induced death.	Iron	138-142	Nedd4 family interacting protein 1	Mus musculus	26-32
22245335-6	2012	The novel mechanism of functional cooperativity in P450 enzymes does not require substantial binding cooperativity, rather it implies the presence of one or more binding sites with higher affinity than the single catalytically active site in the vicinity of the heme iron.	Iron	267-271	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	51-55
24144619-4	2014	We show that binding of the [Fe-S] cluster is mediated by cysteines in an insertion (Pol2(ins)) that is conserved in Pol2 orthologs but is absent in the polymerase domains of Polalpha, Poldelta, and Polzeta.	Iron	29-33	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	85-89
24144619-4	2014	We show that binding of the [Fe-S] cluster is mediated by cysteines in an insertion (Pol2(ins)) that is conserved in Pol2 orthologs but is absent in the polymerase domains of Polalpha, Poldelta, and Polzeta.	Iron	29-33	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	117-121
22356162-1	2012	The recent crystal structure of two monoferric human serum transferrin (Fe(N)hTF) molecules bound to the soluble portion of the homodimeric transferrin receptor (sTFR) has provided new details about this binding interaction that dictates the delivery of iron to cells.	Iron	254-258	transferrin receptor	Homo sapiens	140-160
22356162-9	2012	Collectively, these studies support a model in which a series of pH-induced events involving both TFR residue His318 and hTF residue His349 occurs to promote receptor-stimulated release of iron from the C-lobe of hTF.	Iron	189-193	transferrin receptor	Homo sapiens	98-101
24144619-5	2014	We also show that the [Fe-S] cluster is required for Pol2 polymerase activity but not for its exonuclease activity.	Iron	23-27	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	53-57
24405975-8	2014	The results illustrated that the photocatalytic activity of iron-doped TiO2 was more than pure TiO2, because of the smaller crystal size, grater BET surface area and higher light absorption ability.	Iron	60-64	delta/notch like EGF repeat containing	Homo sapiens	145-148
21699959-6	2012	Because the interaction of hTF with the TFR controls iron distribution in the body, an understanding of this process at the molecular level is essential.	Iron	53-57	transferrin receptor	Homo sapiens	40-43
25147792-3	2014	The iron-sulfur cluster in RtelN is sensitive to hydrogen peroxide and nitric oxide, indicating that reactive oxygen/nitrogen species may modulate the DNA helicase activity of Rtel1 via modification of its iron-sulfur cluster.	Iron	206-210	regulator of telomere elongation helicase 1	Homo sapiens	176-181
21699959-7	2012	MAJOR CONCLUSIONS: Not only does TFR direct the delivery of iron to the cell through the binding of hTF, kinetic data demonstrate that it also modulates iron release from the N- and C-lobes of hTF.	Iron	60-64	transferrin receptor	Homo sapiens	33-36
21699959-7	2012	MAJOR CONCLUSIONS: Not only does TFR direct the delivery of iron to the cell through the binding of hTF, kinetic data demonstrate that it also modulates iron release from the N- and C-lobes of hTF.	Iron	153-157	transferrin receptor	Homo sapiens	33-36
23900040-8	2014	Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression.	Iron	37-41	transferrin receptor	Rattus norvegicus	6-10
21699959-8	2012	Specifically, the TFR balances the rate of iron release from each lobe, resulting in efficient Fe(3+) release within a physiologically relevant time frame.	Iron	43-47	transferrin receptor	Homo sapiens	18-21
21843602-4	2012	SCOPE OF REVIEW: Iron-loaded transferrin (Tf) binds with high affinity to the specific transferrin receptor (TfR) on the cell surface.	Iron	17-21	transferrin receptor	Homo sapiens	87-107
21843602-4	2012	SCOPE OF REVIEW: Iron-loaded transferrin (Tf) binds with high affinity to the specific transferrin receptor (TfR) on the cell surface.	Iron	17-21	transferrin receptor	Homo sapiens	109-112
21843602-5	2012	The Tf-TfR complex is then internalized via receptor mediated endocytosis into an endosome where iron is released.	Iron	97-101	transferrin receptor	Homo sapiens	7-10
21843602-7	2012	GENERAL SIGNIFICANCE: The interaction of the iron-loaded transferrin with the transferrin receptor is a key cellular process that occurs during the normal course of iron metabolism.	Iron	45-49	transferrin receptor	Homo sapiens	78-98
21843602-7	2012	GENERAL SIGNIFICANCE: The interaction of the iron-loaded transferrin with the transferrin receptor is a key cellular process that occurs during the normal course of iron metabolism.	Iron	165-169	transferrin receptor	Homo sapiens	78-98
21843602-10	2012	Iron-loaded transferrin (monoferric or diferric) is shown to bind avidly (K~10(7)-10(8)M(-1)) to the receptor at neutral pH with a stoichiometry of one Tf molecule per TfR monomer.	Iron	0-4	transferrin receptor	Homo sapiens	168-171
21851850-3	2012	The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin.	Iron	53-57	transferrin receptor	Homo sapiens	4-24
21851850-3	2012	The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin.	Iron	53-57	transferrin receptor	Homo sapiens	26-29
23900040-8	2014	Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression.	Iron	37-41	transferrin receptor	Rattus norvegicus	136-140
23900040-8	2014	Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression.	Iron	98-102	transferrin receptor	Rattus norvegicus	6-10
23900040-8	2014	Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression.	Iron	98-102	transferrin receptor	Rattus norvegicus	136-140
23993337-3	2014	We compared peripheral blood mononuclear cell gene expression profiles of eight VHL(R200W) homozygotes with 17 wildtype individuals with normal iron status and found 812 up-regulated and 2120 down-regulated genes at false discovery rate of 0.05.	Iron	144-148	von Hippel-Lindau tumor suppressor	Homo sapiens	80-83
22550532-0	2012	Association of HFE Gene Mutations With Liver Cirrhosis Depends on Induction of Iron Homeostasis Disturbances.	Iron	79-83	homeostatic iron regulator	Homo sapiens	15-18
24697125-0	2014	Validation of a patented method to determine the antioxidant capacity of human saliva based on the reduction of iron: the SAT test.	Iron	112-116	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	122-125
21647550-2	2012	On the other hand, oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD) and heme oxygenase-1 (HO-1), encoded by the HMOX1 gene and heme oxygenase-2 (HO-2), encoded by the HMOX2 gene are important markers of iron-related oxidative stress and its consequences.	Iron	253-257	heme oxygenase 2	Homo sapiens	177-193
22383495-6	2012	PAP7, expressed on the brush border of rat duodenum, copurified with DMT1 in brush border membrane vesicles, and following iron feeding, was internalized in parallel with the internalization of DMT1.	Iron	123-127	acyl-CoA binding domain containing 3	Homo sapiens	0-4
25039779-4	2014	Currently, the iron-binding protein transferrin or antibodies raised against the transferrin receptor denote the most feasible molecule for targeting purposes at the BBB.	Iron	15-19	transferrin receptor	Homo sapiens	81-101
22383495-7	2012	To determine if PAP7 plays a role in cellular iron metabolism, we downregulated PAP7 expression in K562 cells with small interfering RNA.	Iron	46-50	acyl-CoA binding domain containing 3	Homo sapiens	16-20
22407683-11	2012	The novel CTX-M gene bla(CTX-M-105) was flanked by two hypothetical protein sequences, partial ISEcp1 upstream and truncated IS903D, iroN, orf1, and a Tn1721-like element downstream.	Iron	133-137	beta-lactamase	Escherichia coli	21-24
22822413-11	2012	Expression of tTG increased markedly in the iron+Abeta group (p&lt;0.05) and treatment with a tTG inhibitor reduced brain edema (p&lt;0.05) and reduced degenerating neurons (124+-25 vs. 249+-50/mm(2) in vehicle-treated group, p&lt;0.05).	Iron	44-48	transglutaminase 2	Rattus norvegicus	14-17
22135308-8	2012	Network analysis examining the interactions among the differentially expressed genes further supports the notion that Pdx1 may modulate metabolism of lipids and iron from mature intestinal epithelium.	Iron	161-165	pancreatic and duodenal homeobox 1	Mus musculus	118-122
22180422-0	2012	Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron.	Iron	6-10	homeostatic iron regulator	Homo sapiens	54-57
22180422-3	2012	Here we examine the role of maternal and fetal Hfe, its downstream signaling molecule, hepcidin and dietary iron in the regulation of placental iron transfer.	Iron	144-148	homeostatic iron regulator	Homo sapiens	47-50
24164679-8	2014	In summary, we describe TIM-2 as a novel target for ADAM10-mediated ectodomain shedding, and reveal the involvement of ADAM proteases in cellular iron homeostasis.	Iron	146-150	T cell immunoglobulin and mucin domain containing 2	Mus musculus	24-29
22180422-7	2012	RESULTS: Maternal liver iron levels were dependent on both dietary iron intake and Hfe genotype.	Iron	24-28	homeostatic iron regulator	Homo sapiens	83-86
22278021-3	2012	These bone marrow-derived macrophages were able to increase their intracellular iron pool that, in turn, augmented the expression of lipocalin-2 and its receptors.	Iron	80-84	lipocalin 2	Rattus norvegicus	133-144
22101253-0	2012	Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.	Iron	74-78	ferredoxin reductase	Homo sapiens	35-55
22101253-2	2012	More recently, studies in bacteria and yeast have demonstrated important roles for ferredoxin and ferredoxin reductase in iron-sulfur cluster assembly.	Iron	122-126	ferredoxin reductase	Homo sapiens	98-118
25074643-0	2014	Correlation of iron overload and glomerular filtration rate estimated by cystatin C in patients with beta-thalassemia major.	Iron	15-19	cystatin C	Homo sapiens	73-83
22200491-2	2012	The main phenotypic features of frataxin-deficient human and yeast cells include iron accumulation in mitochondria, iron-sulfur cluster defects and high sensitivity to oxidative stress.	Iron	81-85	frataxin	Homo sapiens	32-40
22200491-2	2012	The main phenotypic features of frataxin-deficient human and yeast cells include iron accumulation in mitochondria, iron-sulfur cluster defects and high sensitivity to oxidative stress.	Iron	116-120	frataxin	Homo sapiens	32-40
22278021-6	2012	IL-10-mediated protection and subsequent renal repair were dependent on the presence of iron and lipocalin-2, since the administration of a neutralizing antibody for lipocalin-2 or administration of IL-10 macrophages pretreated with the iron chelating agent deferoxamine abrogated IL-10-mediated protective effects.	Iron	237-241	lipocalin 2	Rattus norvegicus	97-108
22543903-4	2012	demonstrate that macrophages made to overexpress anti-inflammatory interleukin-10 protect rats with AKI through iron-mediated upregulation of lipocalin-2 and its receptors, eliciting both anti-inflammatory and proliferative responses.	Iron	112-116	lipocalin 2	Rattus norvegicus	142-153
22335577-11	2012	In spite of this, it is relevant that two complementary pathways that are regulatory of iron metabolism - the iron export (Fp/HAMP) and the iron import (TFRC/HFE) gene dyads - were embedded in the IRGS gene set and were associated with clinical outcome as well.	Iron	88-92	transferrin receptor	Homo sapiens	153-157
23742320-4	2014	Results found in this work show that hypoxia, generated by eliminating the aeration of the nutrient solution, can limit the expression of several Fe acquisition genes in Fe-deficient Arabidopsis, cucumber and pea plants, like the genes for ferric reductases AtFRO2, PsFRO1 and CsFRO1; iron transporters AtIRT1, PsRIT1 and CsIRT1; H(+) -ATPase CsHA1; and transcription factors AtFIT, AtbHLH38, and AtbHLH39.	Iron	146-148	ferric reduction oxidase 2	Arabidopsis thaliana	258-264
22335577-11	2012	In spite of this, it is relevant that two complementary pathways that are regulatory of iron metabolism - the iron export (Fp/HAMP) and the iron import (TFRC/HFE) gene dyads - were embedded in the IRGS gene set and were associated with clinical outcome as well.	Iron	88-92	homeostatic iron regulator	Homo sapiens	158-161
22335579-2	2012	It inactivates ribonucleotide reductase by disrupting an iron-stabilized radical in ribonucleotide reductase"s small subunits, M2 and M2b (p53R2).	Iron	57-61	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	139-144
22287629-0	2012	DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.	Iron	60-64	helicase for meiosis 1	Homo sapiens	4-12
22287629-0	2012	DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.	Iron	60-64	helicase for meiosis 1	Homo sapiens	17-25
22287629-5	2012	We will discuss testable models for how the conserved Fe-S cluster might operate in helicase and helicase-nuclease enzymes to conduct their specialized functions that help to preserve the integrity of the genome.	Iron	54-58	helicase for meiosis 1	Homo sapiens	84-92
22287629-5	2012	We will discuss testable models for how the conserved Fe-S cluster might operate in helicase and helicase-nuclease enzymes to conduct their specialized functions that help to preserve the integrity of the genome.	Iron	54-58	helicase for meiosis 1	Homo sapiens	97-105
22178670-3	2012	In response to these low iron conditions, many bacteria produce low-molecular-weight iron-binding molecules called siderophores to aid in iron uptake.	Iron	25-29	activation induced cytidine deaminase	Homo sapiens	131-134
22178670-3	2012	In response to these low iron conditions, many bacteria produce low-molecular-weight iron-binding molecules called siderophores to aid in iron uptake.	Iron	85-89	activation induced cytidine deaminase	Homo sapiens	131-134
23742320-5	2014	Interestingly, the limitation of the expression of Fe-acquisition genes by hypoxia did not occur in the Arabidopsis ethylene constitutive mutant ctr1, which suggests that the negative effect of hypoxia is related to ethylene, an hormone involved in the upregulation of Fe acquisition genes.	Iron	51-53	Protein kinase superfamily protein	Arabidopsis thaliana	145-149
22178670-3	2012	In response to these low iron conditions, many bacteria produce low-molecular-weight iron-binding molecules called siderophores to aid in iron uptake.	Iron	85-89	activation induced cytidine deaminase	Homo sapiens	131-134
23700971-4	2014	Expression of OsNRAMP1 in yeast mutant (fet3fet4) rescued iron (Fe) uptake and exhibited enhanced accumulation of As and Cd.	Iron	58-62	ferroxidase FET3	Saccharomyces cerevisiae S288C	40-48
22087469-2	2012	The Fe-POPs possess very high BET surface area, large micropores and showed excellent CO(2) capture (~19 wt%) at 273 K/1 bar.	Iron	4-6	delta/notch like EGF repeat containing	Homo sapiens	30-33
22247543-4	2012	Cellular pools of iron can outcompete manganese for binding to manganese superoxide dismutase, and through Fenton chemistry, iron may counteract the benefits of non-proteinaceous manganese antioxidants.	Iron	18-22	superoxide dismutase 2	Homo sapiens	63-93
23700971-4	2014	Expression of OsNRAMP1 in yeast mutant (fet3fet4) rescued iron (Fe) uptake and exhibited enhanced accumulation of As and Cd.	Iron	64-66	ferroxidase FET3	Saccharomyces cerevisiae S288C	40-48
22236806-2	2012	CcO includes 13 different protein subunits, 7 species of phospholipids, 7 species of triglycerides, 4 redox-active metal sites (Cu(A), heme a (Fe(a)), Cu(B), heme a(3) (Fe(a3))) and 3 redox-inactive metal sites (Mg(2+), Zn(2+) and Na(+)).	Iron	143-145	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-3
22119729-0	2012	Accommodating variety in iron-responsive elements: Crystal structure of transferrin receptor 1 B IRE bound to iron regulatory protein 1.	Iron	25-29	aconitase 1	Homo sapiens	110-135
22236806-2	2012	CcO includes 13 different protein subunits, 7 species of phospholipids, 7 species of triglycerides, 4 redox-active metal sites (Cu(A), heme a (Fe(a)), Cu(B), heme a(3) (Fe(a3))) and 3 redox-inactive metal sites (Mg(2+), Zn(2+) and Na(+)).	Iron	169-171	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-3
24192296-1	2014	In dicots, iron (Fe) is acquired from the soil by IRT1 (IRON-REGULATED TRANSPORTER 1) and FRO2 (FERRIC REDUCTION OXIDASE 2) that are localized at the root epidermis.	Iron	11-15	ferric reduction oxidase 2	Arabidopsis thaliana	90-94
24192296-1	2014	In dicots, iron (Fe) is acquired from the soil by IRT1 (IRON-REGULATED TRANSPORTER 1) and FRO2 (FERRIC REDUCTION OXIDASE 2) that are localized at the root epidermis.	Iron	17-19	ferric reduction oxidase 2	Arabidopsis thaliana	90-94
22631035-3	2012	Increased or excessive activation of the Jak2/STAT5 pathway promotes unnecessary disproportionate proliferation of erythroid progenitors, while other factors suppress serum hepcidin levels leading to dysregulation of iron metabolism.	Iron	217-221	Janus kinase 2	Homo sapiens	41-45
23069304-1	2012	Hereditary hemochromatosis (HHC) is a common genetic disorder of iron overload, caused by mutations in the HFE gene.	Iron	65-69	homeostatic iron regulator	Homo sapiens	107-110
24192296-2	2014	IRT1 and FRO2 expression is induced by local and systemic signals under Fe-deficient conditions in Arabidopsis thaliana.	Iron	72-74	ferric reduction oxidase 2	Arabidopsis thaliana	9-13
24266943-4	2014	The cytosolic Aco in its reduced form operates as an enzyme, whereas in the oxidized form it is involved in the control of iron homeostasis as iron regulatory protein 1 (IRP1).	Iron	123-127	aconitase 1	Homo sapiens	143-168
23560311-2	2012	FRDA is caused by a GAA expansion in intron one of the FXN gene, leading to reduced levels of the encoded protein frataxin, which is thought to regulate cellular iron homeostasis.	Iron	162-166	frataxin	Homo sapiens	114-122
22343016-0	2012	Ceruloplasmin alters intracellular iron regulated proteins and pathways: ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1alpha.	Iron	35-39	transferrin receptor	Homo sapiens	83-103
22343016-10	2012	As predicted by the canonical view of the iron regulatory protein (IRP) as the predominant controller of cellular iron status these results indicate that there is an increase in available iron (called the labile iron pool (LIP)) in the cytoplasm.	Iron	42-46	Wnt family member 2	Homo sapiens	67-70
22343016-10	2012	As predicted by the canonical view of the iron regulatory protein (IRP) as the predominant controller of cellular iron status these results indicate that there is an increase in available iron (called the labile iron pool (LIP)) in the cytoplasm.	Iron	114-118	Wnt family member 2	Homo sapiens	42-65
22343016-10	2012	As predicted by the canonical view of the iron regulatory protein (IRP) as the predominant controller of cellular iron status these results indicate that there is an increase in available iron (called the labile iron pool (LIP)) in the cytoplasm.	Iron	114-118	Wnt family member 2	Homo sapiens	67-70
22343016-10	2012	As predicted by the canonical view of the iron regulatory protein (IRP) as the predominant controller of cellular iron status these results indicate that there is an increase in available iron (called the labile iron pool (LIP)) in the cytoplasm.	Iron	114-118	Wnt family member 2	Homo sapiens	42-65
22343016-10	2012	As predicted by the canonical view of the iron regulatory protein (IRP) as the predominant controller of cellular iron status these results indicate that there is an increase in available iron (called the labile iron pool (LIP)) in the cytoplasm.	Iron	114-118	Wnt family member 2	Homo sapiens	67-70
21936771-2	2012	Frataxin has been implicated in control of iron homoeostasis and Fe-S cluster assembly.	Iron	65-69	frataxin	Homo sapiens	0-8
24266943-4	2014	The cytosolic Aco in its reduced form operates as an enzyme, whereas in the oxidized form it is involved in the control of iron homeostasis as iron regulatory protein 1 (IRP1).	Iron	123-127	aconitase 1	Homo sapiens	170-174
21936771-3	2012	In yeast or human mitochondria, frataxin interacts with components of the Fe-S cluster synthesis machinery, including the cysteine desulfurase Nfs1, accessory protein Isd11 and scaffold protein Isu.	Iron	74-76	frataxin	Homo sapiens	32-40
24373521-2	2013	Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalacia in iron deficient subjects.	Iron	26-30	fibroblast growth factor 23	Rattus norvegicus	72-99
22352884-0	2012	Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis.	Iron	65-69	frataxin	Homo sapiens	53-61
24373521-2	2013	Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalacia in iron deficient subjects.	Iron	26-30	fibroblast growth factor 23	Rattus norvegicus	101-106
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	65-69	frataxin	Homo sapiens	6-9
23227377-3	2012	Considering the high prevalence of iron, folic-acid, and vitamin B(12) deficiencies in developing countries, their coexistence with MPN can be expected frequently.	Iron	35-39	serine protease 27	Homo sapiens	132-135
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	65-69	NFS1 cysteine desulfurase	Homo sapiens	32-36
24376517-1	2013	TMPRSS6 is a regulated gene, with a crucial role in the regulation of iron homeostasis by inhibiting hepcidin expression.	Iron	70-74	transmembrane serine protease 6	Mus musculus	0-7
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	65-69	frataxin	Homo sapiens	49-52
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	130-134	frataxin	Homo sapiens	6-9
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	130-134	NFS1 cysteine desulfurase	Homo sapiens	32-36
22352884-2	2012	Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster biosynthesis reactions.	Iron	130-134	frataxin	Homo sapiens	49-52
22352884-3	2012	In contrast, the Escherichia coli FXN homologue CyaY inhibits Fe-S cluster biosynthesis.	Iron	62-66	frataxin	Homo sapiens	34-37
22352884-6	2012	These data are consistent with a model in which the frataxin-less Fe-S assembly complex exists as a mixture of functional and nonfunctional states, which are stabilized by binding of frataxin homologues.	Iron	66-70	frataxin	Homo sapiens	52-60
22352884-6	2012	These data are consistent with a model in which the frataxin-less Fe-S assembly complex exists as a mixture of functional and nonfunctional states, which are stabilized by binding of frataxin homologues.	Iron	66-70	frataxin	Homo sapiens	183-191
23236259-9	2012	The extracellular mucin stained with Alcian-blue and colloidal iron but not with mucicarmine and D-PAS.	Iron	63-67	LOC100508689	Homo sapiens	18-23
24376517-8	2013	TMPRSS6 inhibition via decreased STAT5 phosphorylation may be an additional mechanism by which inflammation stimulates hepcidin expression to regulate iron homeostasis and immunity.	Iron	151-155	transmembrane serine protease 6	Mus musculus	0-7
22408404-6	2012	HFE testing for the two main mutations (p.Cys282Tyr and p.His63Asp) should be performed in all patients with primary iron overload and unexplained increased transferrin saturation and/or serum ferritin values.	Iron	117-121	homeostatic iron regulator	Homo sapiens	0-3
23999124-0	2013	PKA modulates iron trafficking in the striatum via small GTPase, Rhes.	Iron	14-18	RASD family member 2	Homo sapiens	65-69
23999124-4	2013	We report that Rhes physiologically interacted with Peripheral benzodiazepine receptor-associated protein7 and participated in iron uptake via divalent metal transporter 1 similar to Dexras1.	Iron	127-131	RASD family member 2	Homo sapiens	15-19
22244935-1	2012	Cell surface proteins Hfe, Tfr2, hemojuvelin and Tmprss6 play key roles in iron homeostasis.	Iron	75-79	transmembrane serine protease 6	Mus musculus	49-56
23907672-6	2013	Tf-USPIO enhanced the cellular iron content in TfR-NSCs 80 +- 18 % compared to USPIOs.	Iron	31-35	transferrin receptor	Homo sapiens	47-50
22334566-6	2012	Applying an in situ formed iron-based water reduction catalyst derived from [HNEt(3)](+) [HFe(3)(CO)(11)](-) and tris[3,5-tris-(trifluoromethyl)-phenyl]phosphine as the ligand, [Ir(2-phenylbenz-oxazole)(2)-(bpy)]PF(6) proved to be the most efficient complex giving a quantum yield of 16% at 440 nm light irradiation.	Iron	27-31	sperm associated antigen 17	Homo sapiens	212-217
22095894-3	2012	Although several functions have been described for frataxin, that is, involvement in Fe-S cluster and heme synthesis, energy conversion and oxidative phosphorylation, iron handling and response to oxidative damage, its precise function remains unclear.	Iron	167-171	frataxin	Homo sapiens	51-59
22095894-4	2012	Although there is a general consensus on the participation of frataxin in the maintenance of cellular iron homeostasis and in iron metabolism, this protein may have other specific functions in different tissues and organisms.	Iron	102-106	frataxin	Homo sapiens	62-70
22095894-4	2012	Although there is a general consensus on the participation of frataxin in the maintenance of cellular iron homeostasis and in iron metabolism, this protein may have other specific functions in different tissues and organisms.	Iron	126-130	frataxin	Homo sapiens	62-70
21699959-0	2012	Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.	Iron	12-16	transferrin receptor	Homo sapiens	55-75
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Iron	224-228	delta-6 fatty acyl desaturase	Salmo salar	172-178
21699959-3	2012	SCOPE OF REVIEW: We provide an overview of the kinetics of iron release from hTF+-the transferrin receptor (TFR) at endosomal pH (5.6).	Iron	59-63	transferrin receptor	Homo sapiens	86-106
21699959-3	2012	SCOPE OF REVIEW: We provide an overview of the kinetics of iron release from hTF+-the transferrin receptor (TFR) at endosomal pH (5.6).	Iron	59-63	transferrin receptor	Homo sapiens	108-111
21872645-4	2012	In transferrin loaded with metals other than iron, the dissociation constants for the interaction of the C-lobe with TFR are in a comparable range of magnitudes 10 to 0.5muM, whereas those of the interaction of the N-lobe are several orders of magnitudes lower or not detected.	Iron	45-49	transferrin receptor	Homo sapiens	117-120
21968002-2	2012	Iron-loaded Tf first binds to the Tf receptor (TfR) and enters the cell through clathrin-mediated endocytosis.	Iron	0-4	transferrin receptor	Homo sapiens	34-45
21968002-2	2012	Iron-loaded Tf first binds to the Tf receptor (TfR) and enters the cell through clathrin-mediated endocytosis.	Iron	0-4	transferrin receptor	Homo sapiens	47-50
21880076-2	2012	The Oryza sativa (rice) transcription factor IDEF1 plays a crucial role in regulating iron deficiency-induced genes involved in iron homeostasis.	Iron	128-132	HvIDEF1	Hordeum vulgare	45-50
21880076-4	2012	An immobilized metal ion affinity chromatography assay revealed that IDEF1 and HvIDEF1 bind to various divalent metals, including Fe(2+)  and Ni(2+) .	Iron	130-132	HvIDEF1	Hordeum vulgare	69-74
21880076-4	2012	An immobilized metal ion affinity chromatography assay revealed that IDEF1 and HvIDEF1 bind to various divalent metals, including Fe(2+)  and Ni(2+) .	Iron	130-132	HvIDEF1	Hordeum vulgare	79-86
21880076-5	2012	Recombinant IDEF1 protein expressed in Escherichia coli contained mainly Fe and Zn.	Iron	73-75	HvIDEF1	Hordeum vulgare	12-17
21880076-8	2012	Impairment of the transcriptional regulation of IDEF1 by deletion of the metal-binding domains occurred primarily at an early stage of iron deficiency.	Iron	135-139	HvIDEF1	Hordeum vulgare	48-53
21880076-9	2012	These results suggest that the histidine-asparagine and proline-rich regions in rice IDEF1 directly bind to divalent metals and sense the cellular metal ion balance caused by changes in iron availability.	Iron	186-190	HvIDEF1	Hordeum vulgare	85-90
23744538-11	2013	Analysis of the BMP6/SMAD pathway targets showed that inhibitor of DNA binding 1 (ID1) and SMAD7, but not transmembrane serine protease 6 (TMPRSS6), were up-regulated by increased iron availability and thus may be involved in setting the upper limit of hepcidin.	Iron	180-184	SMAD family member 7	Mus musculus	21-25
23155415-0	2012	Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells.	Iron	31-35	aconitase 1	Homo sapiens	17-21
21930242-3	2012	Both zinc (Zn(2+)) and iron (Fe(2+)) inhibited cellular Cd(2+) uptake through a competitive interaction, suggesting that Cd(2+) enters enterocytes via both Zn(2+) (e.g., ZIP8) and Fe(2+) (e.g., DMT1) transport pathways.	Iron	23-27	solute carrier family 39 member 8	Homo sapiens	170-174
23744538-11	2013	Analysis of the BMP6/SMAD pathway targets showed that inhibitor of DNA binding 1 (ID1) and SMAD7, but not transmembrane serine protease 6 (TMPRSS6), were up-regulated by increased iron availability and thus may be involved in setting the upper limit of hepcidin.	Iron	180-184	SMAD family member 7	Mus musculus	91-96
22469802-2	2012	OBJECTIVE: The aim of this prospective study was to determine whether iron biomarkers and HFE genotypes, which influence iron regulation, constitute risk factors for colorectal cancer.	Iron	121-125	homeostatic iron regulator	Homo sapiens	90-93
22469802-15	2012	HFE genotypes influencing iron uptake had no effect on colorectal cancer risk.	Iron	26-30	homeostatic iron regulator	Homo sapiens	0-3
23110240-0	2012	Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).	Iron	50-54	solute carrier family 39 (zinc transporter), member 14	Mus musculus	17-22
23744538-12	2013	CONCLUSION: We provide evidence that under conditions of excessive and effective erythropoiesis, liver iron regulates hepcidin expression through the BMP6/SMAD pathway.	Iron	103-107	SMAD family member 7	Mus musculus	155-159
23110240-8	2012	In contrast, Zip14(-/-) mice absorbed more iron.	Iron	43-47	solute carrier family 39 (zinc transporter), member 14	Mus musculus	13-18
24437279-1	2013	Transferrin receptor 1(TfR1) is a key cell surface molecule that regulates the uptake of iron-bound transferrin.	Iron	89-93	transferrin receptor	Mus musculus	23-27
23110240-10	2012	Livers of Zip14-/- mice had increased transcript abundance for hepcidin, divalent metal transporter-1, ferritin and transferrin receptor-1 and greater accumulation of iron.	Iron	167-171	solute carrier family 39 (zinc transporter), member 14	Mus musculus	10-15
23110240-14	2012	Our data show the role of ZIP14 in the hepatocyte is multi-functional since zinc and iron trafficking are altered in the Zip14(-/-) mice and their phenotype shows defects in glucose homeostasis.	Iron	85-89	solute carrier family 39 (zinc transporter), member 14	Mus musculus	26-31
23110240-14	2012	Our data show the role of ZIP14 in the hepatocyte is multi-functional since zinc and iron trafficking are altered in the Zip14(-/-) mice and their phenotype shows defects in glucose homeostasis.	Iron	85-89	solute carrier family 39 (zinc transporter), member 14	Mus musculus	121-126
22723983-8	2012	On the other hand, presence of SMAD proteins in iron or TGF-beta-treated cells, including of SMAD4, did confirm convergence of TGF-beta/BMP signaling pathways under these conditions.	Iron	48-52	SMAD family member 4	Homo sapiens	31-35
22666436-11	2012	Our data showed that 1B/(-)IRE DMT1 expression and intracellular iron influx are early downstream responses to NF-kappaB/RelA activation and acetylation during brain ischemia and contribute to the pathogenesis of stroke-induced neuronal damage.	Iron	65-69	RELA proto-oncogene, NF-kB subunit	Homo sapiens	121-125
21545274-3	2011	Recent investigations have identified a host of mitochondrial proteins (e.g., mitochondrial ferritin; mitoferrins 1 and 2; ABCBs 6, 7, and 10; and frataxin) that may play roles in the homeostasis of mitochondrial iron.	Iron	213-217	frataxin	Homo sapiens	147-155
21987576-1	2011	Most eukaryotes contain iron-sulfur cluster (ISC) assembly proteins related to Saccharomyces cerevisiae Isa1 and Isa2.	Iron	24-28	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	104-108
21987576-8	2011	Upon depletion of the ISC assembly factor Iba57, which specifically interacts with Isa1 and Isa2, or in the absence of the major mitochondrial [4Fe-4S] protein aconitase, iron accumulated on the Isa proteins.	Iron	171-175	Iba57p	Saccharomyces cerevisiae S288C	42-47
21987576-9	2011	These results suggest that the iron bound to the Isa proteins is required for the de novo synthesis of [4Fe-4S] clusters in mitochondria and for their insertion into apoproteins in a reaction mediated by Iba57.	Iron	31-35	Iba57p	Saccharomyces cerevisiae S288C	204-209
21839860-8	2011	Both the enzymatic rate of cysteine oxidation and the amount of cross-linking between C93 and Y157 increased significantly upon exposure of CDO to air/oxygen and substrate cysteine in the presence of iron in a hitherto unreported two-phase process.	Iron	200-204	cysteine dioxygenase type 1	Rattus norvegicus	140-143
21769609-5	2011	The formation of this complex is a major determinant of the electrode potential of the cytoplasmic ferrous iron pool, a means of selecting between iron(II) and manganese(II) and it provides a substrate for glutaredoxin/iron clusters at the dimer interface of glutaredoxins involved in the synthesis of Fe-S cluster proteins.	Iron	107-111	glutaredoxin	Homo sapiens	206-218
21769609-5	2011	The formation of this complex is a major determinant of the electrode potential of the cytoplasmic ferrous iron pool, a means of selecting between iron(II) and manganese(II) and it provides a substrate for glutaredoxin/iron clusters at the dimer interface of glutaredoxins involved in the synthesis of Fe-S cluster proteins.	Iron	147-151	glutaredoxin	Homo sapiens	206-218
21769609-5	2011	The formation of this complex is a major determinant of the electrode potential of the cytoplasmic ferrous iron pool, a means of selecting between iron(II) and manganese(II) and it provides a substrate for glutaredoxin/iron clusters at the dimer interface of glutaredoxins involved in the synthesis of Fe-S cluster proteins.	Iron	147-151	glutaredoxin	Homo sapiens	206-218
21769609-5	2011	The formation of this complex is a major determinant of the electrode potential of the cytoplasmic ferrous iron pool, a means of selecting between iron(II) and manganese(II) and it provides a substrate for glutaredoxin/iron clusters at the dimer interface of glutaredoxins involved in the synthesis of Fe-S cluster proteins.	Iron	302-304	glutaredoxin	Homo sapiens	206-218
21971347-9	2011	We report that cytosolic XRCC5 is increased in response to Cu, but not zinc, iron, or nickel, and the level of cytosolic XRCC5 correlates with protection against oxidative damage to DNA.	Iron	77-81	X-ray repair cross complementing 5	Homo sapiens	25-30
22068234-8	2011	The inhibitory kinase Fes phosphorylates mainly the inhibitory motif for CD84.	Iron	22-25	CD84 molecule	Homo sapiens	73-77
22068234-9	2011	Moreover, Fes, which has been described to become phosphorylated after substrate binding, also gets phosphorylated when coexpressed with CD84.	Iron	10-13	CD84 molecule	Homo sapiens	137-141
22068234-10	2011	Consistently, Fes was observed to be more phosphorylated after CD84 and FcepsilonRI co-cross-linking.	Iron	14-17	CD84 molecule	Homo sapiens	63-67
22068234-10	2011	Consistently, Fes was observed to be more phosphorylated after CD84 and FcepsilonRI co-cross-linking.	Iron	14-17	Fc epsilon receptor Ia	Homo sapiens	72-83
21863062-1	2011	The mitochondrial protein frataxin (FXN) is known to be involved in mitochondrial iron homeostasis and iron-sulfur cluster biogenesis.	Iron	82-86	frataxin	Homo sapiens	26-34
21863062-1	2011	The mitochondrial protein frataxin (FXN) is known to be involved in mitochondrial iron homeostasis and iron-sulfur cluster biogenesis.	Iron	82-86	frataxin	Homo sapiens	36-39
21863062-1	2011	The mitochondrial protein frataxin (FXN) is known to be involved in mitochondrial iron homeostasis and iron-sulfur cluster biogenesis.	Iron	103-107	frataxin	Homo sapiens	26-34
21862411-1	2011	Iron disorders of genetic origin are mainly composed of iron overload diseases, the most frequent being HFE-related hemochromatosis.	Iron	0-4	homeostatic iron regulator	Homo sapiens	104-107
21862411-1	2011	Iron disorders of genetic origin are mainly composed of iron overload diseases, the most frequent being HFE-related hemochromatosis.	Iron	56-60	homeostatic iron regulator	Homo sapiens	104-107
21940823-2	2011	The currently known IRP-binding mRNAs encode proteins involved in iron uptake, storage, and release as well as heme synthesis.	Iron	66-70	wingless-type MMTV integration site family, member 2	Mus musculus	20-23
21940823-6	2011	This work investigates cellular iron metabolism in unprecedented depth and defines a wide network of mRNAs and proteins with iron-dependent regulation, IRP-dependent regulation, or both.	Iron	32-36	wingless-type MMTV integration site family, member 2	Mus musculus	152-155
21967605-0	2011	4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.	Iron	131-135	APC regulator of WNT signaling pathway	Homo sapiens	67-70
21777202-0	2011	Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria.	Iron	55-59	Rim2p	Saccharomyces cerevisiae S288C	0-4
21777202-6	2011	Rim2 overexpression was able to enhance haem and Fe-S cluster synthesis in wild-type or Deltamrs3/Deltamrs4 backgrounds.	Iron	49-53	Rim2p	Saccharomyces cerevisiae S288C	0-4
21777202-7	2011	Conversely Rim2 depletion impaired haem and Fe-S cluster synthesis in wild-type or Deltamrs3/Deltamrs4 backgrounds, indicating a unique requirement for this mitochondrial transporter for these processes.	Iron	44-48	Rim2p	Saccharomyces cerevisiae S288C	11-15
21777202-9	2011	In the present study we found that isolated mitochondria lacking Rim2 exhibited concordant iron defects and pyrimidine transport defects, although the connection between these two functions is not explained.	Iron	91-95	Rim2p	Saccharomyces cerevisiae S288C	65-69
21777202-11	2011	The results indicate that Rim2 is a pyrimidine exchanger with an additional unique function in promoting mitochondrial iron utilization.	Iron	119-123	Rim2p	Saccharomyces cerevisiae S288C	26-30
21969573-5	2011	These effects were further enhanced by inactivating iron-binding residues of Lcn-2, suggesting that they were facilitated by the iron-free form of Lcn-2.	Iron	52-56	lipocalin 2	Mus musculus	77-82
21969573-5	2011	These effects were further enhanced by inactivating iron-binding residues of Lcn-2, suggesting that they were facilitated by the iron-free form of Lcn-2.	Iron	52-56	lipocalin 2	Mus musculus	147-152
21969573-5	2011	These effects were further enhanced by inactivating iron-binding residues of Lcn-2, suggesting that they were facilitated by the iron-free form of Lcn-2.	Iron	129-133	lipocalin 2	Mus musculus	77-82
21969573-5	2011	These effects were further enhanced by inactivating iron-binding residues of Lcn-2, suggesting that they were facilitated by the iron-free form of Lcn-2.	Iron	129-133	lipocalin 2	Mus musculus	147-152
21917924-7	2011	Deletion of TYW1 in a Deltaccc1 strain led to increased iron sensitivity.	Iron	56-60	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	12-16
21917924-9	2011	We conclude that the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters.	Iron	83-87	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	48-52
21917924-9	2011	We conclude that the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters.	Iron	134-138	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	48-52
21917924-9	2011	We conclude that the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters.	Iron	134-138	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	48-52
21190189-1	2011	HFE is a protein that impacts cellular iron uptake.	Iron	39-43	homeostatic iron regulator	Homo sapiens	0-3
21870996-1	2011	A number of antibodies have been developed that induce lethal iron deprivation (LID) by targeting the transferrin receptor 1 (TfR1/CD71) and either neutralizing transferrin (Tf) binding, blocking internalization of the receptor and/or inducing its degradation.	Iron	62-66	transferrin receptor	Homo sapiens	126-130
21870996-1	2011	A number of antibodies have been developed that induce lethal iron deprivation (LID) by targeting the transferrin receptor 1 (TfR1/CD71) and either neutralizing transferrin (Tf) binding, blocking internalization of the receptor and/or inducing its degradation.	Iron	62-66	transferrin receptor	Homo sapiens	131-135
22210761-10	2012	In addition to alginate biosynthetic and regulatory genes, KinB and RpoN also control a large number of genes including those involved in carbohydrate metabolism, quorum sensing, iron regulation, rhamnolipid production, and motility.	Iron	179-183	RNA polymerase factor sigma-54	Pseudomonas aeruginosa PAO1	68-72
22331876-2	2012	However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in the Heph protein are able to absorb dietary iron despite reduced expression and mislocalization of the mutant protein.	Iron	121-125	hephaestin	Mus musculus	9-26
22331876-2	2012	However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in the Heph protein are able to absorb dietary iron despite reduced expression and mislocalization of the mutant protein.	Iron	121-125	hephaestin	Mus musculus	28-31
22331876-2	2012	However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in the Heph protein are able to absorb dietary iron despite reduced expression and mislocalization of the mutant protein.	Iron	121-125	hephaestin	Mus musculus	81-85
22117066-0	2012	Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation.	Iron	72-76	lipocalin 2	Rattus norvegicus	0-11
22117066-7	2012	Importantly, we used the fluorescent probe Phen Green SK to demonstrate an increase in intracellular iron in response to Lcn2, and depleting intracellular iron using an iron chelator prevented Lcn2-induced cardiomyocyte apoptosis.	Iron	101-105	lipocalin 2	Rattus norvegicus	121-125
22117066-7	2012	Importantly, we used the fluorescent probe Phen Green SK to demonstrate an increase in intracellular iron in response to Lcn2, and depleting intracellular iron using an iron chelator prevented Lcn2-induced cardiomyocyte apoptosis.	Iron	101-105	lipocalin 2	Rattus norvegicus	193-197
22117066-7	2012	Importantly, we used the fluorescent probe Phen Green SK to demonstrate an increase in intracellular iron in response to Lcn2, and depleting intracellular iron using an iron chelator prevented Lcn2-induced cardiomyocyte apoptosis.	Iron	155-159	lipocalin 2	Rattus norvegicus	193-197
22117066-7	2012	Importantly, we used the fluorescent probe Phen Green SK to demonstrate an increase in intracellular iron in response to Lcn2, and depleting intracellular iron using an iron chelator prevented Lcn2-induced cardiomyocyte apoptosis.	Iron	155-159	lipocalin 2	Rattus norvegicus	193-197
22117066-9	2012	In conclusion, Lcn2-induced cardiomyocyte apoptosis is of physiological significance and occurs via a mechanism involving elevated intracellular iron levels and Bax translocation.	Iron	145-149	lipocalin 2	Rattus norvegicus	15-19
20974500-3	2012	Our aim was to test the hypothesis that anthracyclines increase iron heart concentration and that HFE genotype modulates this iron deposit.	Iron	126-130	homeostatic iron regulator	Homo sapiens	98-101
20974500-10	2012	In a multivariate linear regression analysis both HFE genotypes and anthracyclines contributed to heart iron concentration (R(2)=0.284).	Iron	104-108	homeostatic iron regulator	Homo sapiens	50-53
20974500-11	2012	CONCLUSIONS: Our data support the occurrence of an HFE-modulated heart iron accumulation in individuals treated with anthracyclines, independently of systemic iron load.	Iron	71-75	homeostatic iron regulator	Homo sapiens	51-54
22101253-8	2012	Moreover, knockdown of the sole human ferredoxin reductase, FDXR, diminished iron-sulfur cluster assembly and caused mitochondrial iron overload in conjunction with cytosolic depletion.	Iron	77-81	ferredoxin reductase	Homo sapiens	38-58
22101253-8	2012	Moreover, knockdown of the sole human ferredoxin reductase, FDXR, diminished iron-sulfur cluster assembly and caused mitochondrial iron overload in conjunction with cytosolic depletion.	Iron	77-81	ferredoxin reductase	Homo sapiens	60-64
22101253-8	2012	Moreover, knockdown of the sole human ferredoxin reductase, FDXR, diminished iron-sulfur cluster assembly and caused mitochondrial iron overload in conjunction with cytosolic depletion.	Iron	131-135	ferredoxin reductase	Homo sapiens	38-58
22101253-8	2012	Moreover, knockdown of the sole human ferredoxin reductase, FDXR, diminished iron-sulfur cluster assembly and caused mitochondrial iron overload in conjunction with cytosolic depletion.	Iron	131-135	ferredoxin reductase	Homo sapiens	60-64
22101253-9	2012	Our studies suggest that interference with any of the three related genes, FDX1, FDX2 or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis.	Iron	104-108	ferredoxin reductase	Homo sapiens	89-93
22101253-9	2012	Our studies suggest that interference with any of the three related genes, FDX1, FDX2 or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis.	Iron	187-191	ferredoxin reductase	Homo sapiens	89-93
21826460-11	2012	Overall, our data suggest that ZIP5, ZIP6, ZIP7, and ZIP10 are regulated by iron, indicating that they may play a role in hepatic iron/metal homeostasis during iron deficiency and overload.	Iron	76-80	solute carrier family 39 (zinc transporter), member 4-like	Rattus norvegicus	53-58
21826460-11	2012	Overall, our data suggest that ZIP5, ZIP6, ZIP7, and ZIP10 are regulated by iron, indicating that they may play a role in hepatic iron/metal homeostasis during iron deficiency and overload.	Iron	130-134	solute carrier family 39 (zinc transporter), member 4-like	Rattus norvegicus	53-58
22118647-0	2012	The impact of HFE mutations on haemoglobin and iron status in individuals experiencing repeated iron loss through blood donation*.	Iron	47-51	homeostatic iron regulator	Homo sapiens	14-17
22118647-0	2012	The impact of HFE mutations on haemoglobin and iron status in individuals experiencing repeated iron loss through blood donation*.	Iron	96-100	homeostatic iron regulator	Homo sapiens	14-17
22118647-4	2012	Donors with two HFE mutations had increased baseline haemoglobin and iron stores as did those with one mutation, albeit to a lesser extent.	Iron	69-73	homeostatic iron regulator	Homo sapiens	16-19
22118647-5	2012	Over multiple donations haemoglobin and iron status of donors with HFE mutations paralleled those lacking mutations.	Iron	40-44	homeostatic iron regulator	Homo sapiens	67-70
21993671-1	2012	BACKGROUND: Patients with Chuvash polycythemia, (homozygosity for the R200W mutation in the von Hippel Lindau gene (VHL)), have elevated levels of hypoxia inducible factors HIF-1 and HIF-2, often become iron-deficient secondary to phlebotomy, and have elevated estimated pulmonary artery pressure by echocardiography.	Iron	203-207	von Hippel-Lindau tumor suppressor	Homo sapiens	116-119
21749488-10	2012	The area-under-the-curve from baseline to 210min was lower in the TB+P2 (-78.8mumol min L(-1) ) group compared to the other bread interventions, indicating higher levels of iron absorption in this group.	Iron	173-177	TATA-box binding protein like 2	Homo sapiens	66-71
22198253-2	2012	Clinical manifestations usually occur in individuals homozygous for the C282Y mutation in the HFE gene product and who have developed significant iron loading.	Iron	146-150	homeostatic iron regulator	Homo sapiens	94-97
22198253-5	2012	HFE genotyping, when combined with serum biochemical measurements, defines the presence of likely iron overload and the underlying genetic disorder and is the preferred initial screening modality for families of an affected individual.	Iron	98-102	homeostatic iron regulator	Homo sapiens	0-3
22294093-5	2012	Computational modeling and experiments suggest that the role of the iron-sulfur cluster biosynthesis pathway in infection is indirect, via competitive binding of the shared sulfur donor IscS.	Iron	68-72	NFS1 cysteine desulfurase	Homo sapiens	186-190
22191507-1	2012	Efficient delivery of iron is critically dependent on the binding of diferric human serum transferrin (hTF) to its specific receptor (TFR) on the surface of actively dividing cells.	Iron	22-26	transferrin receptor	Homo sapiens	134-137
22191507-4	2012	Identification of the specific residues accounting for the pH-sensitive nanomolar affinity with which hTF binds to TFR throughout the cycle is important to fully understand the iron delivery process.	Iron	177-181	transferrin receptor	Homo sapiens	115-118
22191507-5	2012	Alanine substitution of 11 charged hTF residues identified by available structures and modeling studies allowed evaluation of the role of each in (1) binding of hTF to the TFR and (2) TFR-mediated iron release.	Iron	197-201	transferrin receptor	Homo sapiens	184-187
22191507-8	2012	Moreover, mutation of three residues (Asp356, Glu367, and Lys511), whether in the diferric or monoferric C-lobe hTF, significantly affected iron release when in complex with the TFR.	Iron	140-144	transferrin receptor	Homo sapiens	178-181
22191507-9	2012	Thus, mutagenesis of charged hTF residues has allowed identification of a number of residues that are critical to formation of and release of iron from the hTF-TFR complex.	Iron	142-146	transferrin receptor	Homo sapiens	160-163
22122511-7	2012	Mossbauer spectra show that in its resting state CDO binds the iron as high-spin iron(II).	Iron	63-67	cysteine dioxygenase type 1	Rattus norvegicus	49-52
22154776-14	2012	A decrease in macrophage intracellular iron plays an important role in this nonfoam cell phenotype by reducing ROS, which drives transcription of ABC transporters through activation of LXRalpha.	Iron	39-43	nuclear receptor subfamily 1 group H member 3	Homo sapiens	185-193
23046645-3	2012	Iron-bearing hTF in the blood binds tightly to the specific transferrin receptor (TFR), a homodimeric transmembrane protein.	Iron	0-4	transferrin receptor	Homo sapiens	60-80
23046645-3	2012	Iron-bearing hTF in the blood binds tightly to the specific transferrin receptor (TFR), a homodimeric transmembrane protein.	Iron	0-4	transferrin receptor	Homo sapiens	82-85
23046645-5	2012	Iron-free hTF remains tightly bound to the TFR at acidic pH; following recycling back to the cell surface, it is released to sequester more iron.	Iron	0-4	transferrin receptor	Homo sapiens	43-46
23046645-6	2012	Efficient delivery of iron is critically dependent on hTF/TFR interactions.	Iron	22-26	transferrin receptor	Homo sapiens	58-61
22122796-1	2012	Co-inheritance of mutations in the HFE gene underlying hereditary hemocromatosis (HH) may play a role in the variability of iron status in patients with beta-thalassemia (beta-thal) minor.	Iron	124-128	homeostatic iron regulator	Homo sapiens	35-38
22122796-2	2012	Different studies have yielded conflicting results: some suggest iron overload might arise from the interaction of the beta-thal trait with homozygosity or even heterozygosity for HFE mutations and others that it was unrelated to the HFE genotype.	Iron	65-69	homeostatic iron regulator	Homo sapiens	180-183
22122796-4	2012	A retrospective analysis of 142 individuals heterozygous for beta-thal was performed to investigate the effect of HFE mutations on iron status of these patients.	Iron	131-135	homeostatic iron regulator	Homo sapiens	114-117
21880076-0	2012	The rice transcription factor IDEF1 directly binds to iron and other divalent metals for sensing cellular iron status.	Iron	54-58	HvIDEF1	Hordeum vulgare	30-35
21880076-0	2012	The rice transcription factor IDEF1 directly binds to iron and other divalent metals for sensing cellular iron status.	Iron	106-110	HvIDEF1	Hordeum vulgare	30-35
21880076-2	2012	The Oryza sativa (rice) transcription factor IDEF1 plays a crucial role in regulating iron deficiency-induced genes involved in iron homeostasis.	Iron	86-90	HvIDEF1	Hordeum vulgare	45-50
23185529-4	2012	Lipocalin 2 (Lcn2) is a member of the lipocalin family of proteins and binds to bacterial siderophores thereby sequestering iron required for bacterial growth.	Iron	124-128	lipocalin 2	Mus musculus	13-17
23049850-1	2012	Frataxin (FXN) is an alpha/beta protein that plays an essential role in iron homeostasis.	Iron	72-76	frataxin	Homo sapiens	0-8
23049850-1	2012	Frataxin (FXN) is an alpha/beta protein that plays an essential role in iron homeostasis.	Iron	72-76	frataxin	Homo sapiens	10-13
22530027-4	2012	Human HFE is a MHC class I protein mainly expressed in the liver that, when mutated, can cause hereditary hemochromatosis, a common genetic disorder of iron metabolism.	Iron	152-156	homeostatic iron regulator	Homo sapiens	6-9
23196478-5	2012	Transferrin-bound iron (Tf-Fe(3+)) binds to the transferrin receptor 1 (TR1) on the luminal membrane of the endothelial cells, and then Tf-Fe(3+)-TR1 complex is internalized in the endosomes.	Iron	18-22	taste 1 receptor member 1	Homo sapiens	48-70
23196478-5	2012	Transferrin-bound iron (Tf-Fe(3+)) binds to the transferrin receptor 1 (TR1) on the luminal membrane of the endothelial cells, and then Tf-Fe(3+)-TR1 complex is internalized in the endosomes.	Iron	18-22	taste 1 receptor member 1	Homo sapiens	72-75
23196478-5	2012	Transferrin-bound iron (Tf-Fe(3+)) binds to the transferrin receptor 1 (TR1) on the luminal membrane of the endothelial cells, and then Tf-Fe(3+)-TR1 complex is internalized in the endosomes.	Iron	18-22	taste 1 receptor member 1	Homo sapiens	146-149
22152479-3	2011	In this work, we demonstrate that yeast cells control RNR function during iron deficiency by redistributing the Rnr2-Rnr4 small subunit from the nucleus to the cytoplasm.	Iron	74-78	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	112-116
22152479-3	2011	In this work, we demonstrate that yeast cells control RNR function during iron deficiency by redistributing the Rnr2-Rnr4 small subunit from the nucleus to the cytoplasm.	Iron	74-78	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	117-121
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	65-69	serine/threonine/tyrosine protein kinase RAD53	Saccharomyces cerevisiae S288C	24-29
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	65-69	transcriptional modulator	Saccharomyces cerevisiae S288C	143-147
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	168-172	serine/threonine/tyrosine protein kinase RAD53	Saccharomyces cerevisiae S288C	24-29
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	168-172	transcriptional modulator	Saccharomyces cerevisiae S288C	143-147
21859709-2	2011	TfR1 is highly expressed in cancer cells, particularly under iron deficient conditions.	Iron	61-65	transferrin receptor	Homo sapiens	0-4
21859709-3	2011	Overexpression of TfR1 is thought to meet the increased requirement of iron uptake necessary for cell growth.	Iron	71-75	transferrin receptor	Homo sapiens	18-22
21978626-11	2011	Carriers of the minor allele of rs3811647 present a reduction in iron transport to tissues, which might indicate higher iron deficiency anaemia risk, although the simultaneous presence of the minor allele of rs1799852 and HFE mutations appear to have compensatory effects.	Iron	65-69	homeostatic iron regulator	Homo sapiens	222-225
21815188-7	2011	A high prevalence of HFE gene mutations exists in this population and may contribute to iron-related morbidity.	Iron	88-92	homeostatic iron regulator	Homo sapiens	21-24
21653899-0	2011	Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.	Iron	151-155	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-5
21653899-1	2011	Recent studies have shown that overexpression of the transmembrane protein Zrt- and Irt-like protein 14 (Zip14) stimulates the cellular uptake of zinc and nontransferrin-bound iron (NTBI).	Iron	176-180	solute carrier family 39 (zinc transporter), member 14	Mus musculus	105-110
21653899-3	2011	Expression of mouse Zip14 in RNA-injected oocytes stimulated the uptake of (55)Fe in the presence of l-ascorbate but not nitrilotriacetic acid, indicating that Zip14 is an iron transporter specific for ferrous ion (Fe(2+)) over ferric ion (Fe(3+)).	Iron	79-81	solute carrier family 39 (zinc transporter), member 14	Mus musculus	20-25
21653899-3	2011	Expression of mouse Zip14 in RNA-injected oocytes stimulated the uptake of (55)Fe in the presence of l-ascorbate but not nitrilotriacetic acid, indicating that Zip14 is an iron transporter specific for ferrous ion (Fe(2+)) over ferric ion (Fe(3+)).	Iron	79-81	solute carrier family 39 (zinc transporter), member 14	Mus musculus	160-165
21747058-0	2011	Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.	Iron	0-4	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	24-30
21747058-10	2011	CONCLUSIONS: Our results demonstrate that CIO selectively reduces Ca(V)1.3-mediated I(Ca,L), leading to bradycardia, slowing of electrical conduction, and atrial fibrillation as seen in patients with iron overload.	Iron	200-204	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	66-74
21931161-5	2011	rnr4 mutants are defective in iron loading into nascent beta and are hypersensitive to iron depletion and the Tyr( )-reducing agent hydroxyurea.	Iron	30-34	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	0-4
21931161-5	2011	rnr4 mutants are defective in iron loading into nascent beta and are hypersensitive to iron depletion and the Tyr( )-reducing agent hydroxyurea.	Iron	87-91	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	0-4
24437279-3	2013	Thus, intracellular targeting using iron-saturated Tf as a ligand for TfR-mediated endocytosis has attracted attention.	Iron	36-40	transferrin receptor	Mus musculus	70-73
24282517-1	2013	Hereditary Hemochromatosis (HH) is a recessively inherited disorder of iron overload occurring commonly in subjects homozygous for the C282Y mutation in HFE gene localized on chromosome 6p21.3 in linkage disequilibrium with the human leukocyte antigen (HLA)-A locus.	Iron	71-75	homeostatic iron regulator	Homo sapiens	153-156
21894998-3	2011	It has been conjectured that the sequential one-electron transfers observed for Fe are due to the lack of an accessible eta(4):eta(6) Fe(0) state, destabilizing the fully reduced species.	Iron	80-82	endothelin receptor type A	Homo sapiens	120-123
21894998-3	2011	It has been conjectured that the sequential one-electron transfers observed for Fe are due to the lack of an accessible eta(4):eta(6) Fe(0) state, destabilizing the fully reduced species.	Iron	80-82	endothelin receptor type A	Homo sapiens	127-130
21917924-0	2011	Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity.	Iron	79-83	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	44-48
21917924-2	2011	We identified genes regulated by Yap5 in response to iron and show that one of the genes induced is TYW1, which encodes an iron-sulfur cluster enzyme that participates in the synthesis of wybutosine-modified tRNA.	Iron	53-57	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	100-104
21683107-8	2011	We postulate that, as in the periphery, LCN2 may have a role in iron transport or trafficking in the CNS.	Iron	64-68	lipocalin 2	Rattus norvegicus	40-44
24238610-2	2013	LeFRO1 is a major ferric-chelate reductase involved in iron uptake in tomato.	Iron	55-59	ferric-chelate reductase	Solanum lycopersicum	0-6
21768302-0	2011	Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake.	Iron	65-69	ceruloplasmin	Rattus norvegicus	6-19
21768302-2	2011	One point of intersection between the 2 metals is the liver-derived, multicopper ferroxidase ceruloplasmin (Cp) that is important for iron release from certain tissues.	Iron	134-138	ceruloplasmin	Rattus norvegicus	93-106
21917924-2	2011	We identified genes regulated by Yap5 in response to iron and show that one of the genes induced is TYW1, which encodes an iron-sulfur cluster enzyme that participates in the synthesis of wybutosine-modified tRNA.	Iron	123-127	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	100-104
21710167-2	2011	The diagnosis of iron deficiency anemia relies on a full blood count including hemoglobin, serum ferritin, and serum soluble transferrin receptor, which appear to be reliable indicators of anemia and iron status 1 week postpartum while serum transferrin saturation is an unreliable indicator several weeks after delivery.	Iron	17-21	transferrin receptor	Homo sapiens	125-145
21907140-0	2011	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.	Iron	46-50	F-box and leucine-rich repeat protein 5	Mus musculus	4-9
24238610-7	2013	In conclusion, the findings are helpful to understand the natural adaptation mechanisms of plants to iron-limiting stress, and may provide new knowledge to select and manipulate LeFRO1 for improving the iron deficiency tolerance in tomato.	Iron	101-105	ferric-chelate reductase	Solanum lycopersicum	178-184
21907140-2	2011	Although FBXL5 (F box and leucine-rich repeat protein 5) is thought to mediate this degradation, the role of FBXL5 in the control of iron homeostasis in vivo has been poorly understood.	Iron	133-137	F-box and leucine-rich repeat protein 5	Mus musculus	109-114
21907140-3	2011	We have now found that mice deficient in FBXL5 died in utero, associated with excessive iron accumulation.	Iron	88-92	F-box and leucine-rich repeat protein 5	Mus musculus	41-46
23877998-2	2013	SRR showed excellent specificity for Cu(2+) ions over other cations (including Cu(+), Hg(2+), and Fe(3+)), very high sensitivity (10 nM), and a rapid response time (3 min).	Iron	98-100	serine racemase	Homo sapiens	0-3
21907140-5	2011	We also found that liver-specific deletion of Fbxl5 resulted in deregulation of both hepatic and systemic iron homeostasis, leading to the development of steatohepatitis.	Iron	106-110	F-box and leucine-rich repeat protein 5	Mus musculus	46-51
21907140-7	2011	Thus, our results uncover a major role for FBXL5 in ensuring an appropriate supply of iron to cells.	Iron	86-90	F-box and leucine-rich repeat protein 5	Mus musculus	43-48
21704079-7	2011	CD69 nano-domains polarizing on membrane-peak fluctuations might serve as transient platforms driving TCR/CD3-induced signaling and activation, whereas CD71 nano-domains distributing in the membrane-valley fluctuations appeared to facilitate iron uptake for increased metabolisms in T-cell activation.	Iron	242-246	CD69 molecule	Homo sapiens	0-4
21704079-7	2011	CD69 nano-domains polarizing on membrane-peak fluctuations might serve as transient platforms driving TCR/CD3-induced signaling and activation, whereas CD71 nano-domains distributing in the membrane-valley fluctuations appeared to facilitate iron uptake for increased metabolisms in T-cell activation.	Iron	242-246	transferrin receptor	Homo sapiens	152-156
21903580-0	2011	5-aza-2"-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.	Iron	33-37	transferrin receptor	Mus musculus	138-160
21903580-0	2011	5-aza-2"-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.	Iron	33-37	transferrin receptor	Mus musculus	162-166
21768301-7	2011	In preclinical experiments using interventions such as transferrin, hepcidin agonists, and JAK2 inhibitors, we provide evidence of potential new treatment alternatives that elucidate mechanisms by which expanded or ineffective erythropoiesis may regulate iron supply, distribution, and utilization in diseases such as beta-thalassemia.	Iron	255-259	Janus kinase 2	Homo sapiens	91-95
21359952-0	2011	Glucocorticoid causes iron accumulation in liver by up-regulating expression of iron regulatory protein 1 gene through GR and STAT5.	Iron	22-26	aconitase 1	Rattus norvegicus	80-105
21359952-1	2011	Iron regulatory protein-1 (IRP-1) is a central factor in the regulation of iron metabolism.	Iron	75-79	aconitase 1	Rattus norvegicus	0-25
21359952-1	2011	Iron regulatory protein-1 (IRP-1) is a central factor in the regulation of iron metabolism.	Iron	75-79	aconitase 1	Rattus norvegicus	27-32
21729755-1	2011	Ferritin, the iron storage protein, plays a key role in iron metabolism.	Iron	14-18	soma ferritin-like	Crassostrea gigas	0-8
21653899-10	2011	Whereas zinc appears to be a preferred substrate under normal conditions, we found that Zip14 is capable of mediating cellular uptake of NTBI characteristic of iron-overload conditions.	Iron	160-164	solute carrier family 39 (zinc transporter), member 14	Mus musculus	88-93
24048084-3	2013	RECENT FINDINGS: Genome-wide association studies identified six genetic variants including MEIS1 and BTBD9 with potential relationships with iron.	Iron	141-145	BTB domain containing 9	Homo sapiens	101-106
21712541-0	2011	Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation.	Iron	112-116	Janus kinase 2	Homo sapiens	54-58
21785125-0	2011	Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.	Iron	53-57	homeostatic iron regulator	Homo sapiens	15-18
21785125-4	2011	The size of the study population was underpowered to find genome wide significant associations with hepcidin concentrations but it allowed to show that association with serum iron, transferrin saturation and erythrocyte traits of common DNA variants in HFE (rs1800562) and TMPRSS6 (rs855791) genes is not exclusively dependent on hepcidin values.	Iron	175-179	homeostatic iron regulator	Homo sapiens	253-256
21785125-6	2011	CONCLUSIONS: The results suggest a mutual control of serum hepcidin and ferritin concentrations, a mechanism relevant to the pathophysiology of HFE haemochromatosis, and demonstrate that the HFE rs1800562 C282Y variant exerts a direct pleiotropic effect on the iron parameters, in part independent of hepcidin.	Iron	261-265	homeostatic iron regulator	Homo sapiens	144-147
23481176-2	2013	TSS-SPIONs were developed by chelation between thiolated chitosan-thioglycolic acid (chitosan-TGA) hydrogel and iron ions (Fe(2+)/Fe(3+)).	Iron	112-116	T-box transcription factor 1	Homo sapiens	94-97
22024494-7	2011	Superoxide dismutase (Sod1) and ceruloplasmin protein were found to be altered by both iron and CuD, whereas CCS and CCS/Sod1 ratio were found to only be altered only in CuD rats and, importantly, after only 1 week of treatment.	Iron	87-91	ceruloplasmin	Rattus norvegicus	32-45
22400279-3	2011	The structure of the Pd1-xFe(x) thin film with x = 0.14, 0.24, and 0.52 was determined by X-ray diffraction (XRD) and transmission electron microscopy (TEM) as a solid solution of iron in palladium face-centered cubic lattice with the (111) orientation of nanograins relatively to the substrate surface.	Iron	180-184	programmed cell death 1	Homo sapiens	21-24
24552065-7	2013	10% ZVI PRB barrier material had the highest mean porosity (56%) after exposure to any water chemistry whilst 100% ZVI (W/W) columns always had the lowest (34%) with the 50% ZVI (W/W) in between (40%).	Iron	4-7	RB transcriptional corepressor 1	Homo sapiens	8-11
21917813-7	2011	Mice with mutations in the hephaestin gene (sex-linked anemia mice) show iron accumulation in oligodendrocytes in the gray matter, but not in the white matter, and exhibit motor deficits.	Iron	73-77	hephaestin	Mus musculus	27-37
21917813-10	2011	This was further confirmed in ceruloplasmin/hephaestin double-mutant mice, which show iron accumulation in both gray and white matter oligodendrocytes.	Iron	86-90	hephaestin	Mus musculus	44-54
21907923-2	2011	Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha.	Iron	108-112	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	8-12
21907923-2	2011	Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha.	Iron	108-112	aconitase 1	Homo sapiens	164-168
21776984-0	2011	Structure-function analysis of Friedreich"s ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex.	Iron	122-126	frataxin	Homo sapiens	83-91
21776984-3	2011	In vitro assays revealed that although the three FRDA missense mutations exhibited similar losses of cysteine desulfurase and Fe-S cluster assembly activities, the causes for these activation defects were distinct.	Iron	126-130	frataxin	Homo sapiens	49-53
21776984-5	2011	The order of the FXN binding affinities for the SDU Fe-S assembly complex was as follows: FXN > Q148R > N146A > Q148G > N146K > Q153A > R165C.	Iron	52-56	frataxin	Homo sapiens	17-20
21776984-5	2011	The order of the FXN binding affinities for the SDU Fe-S assembly complex was as follows: FXN > Q148R > N146A > Q148G > N146K > Q153A > R165C.	Iron	52-56	frataxin	Homo sapiens	90-93
21776984-7	2011	Together, these structure-function studies reveal determinants for the binding and allosteric activation of the Fe-S assembly complex and provide insight into how FRDA missense mutations are functionally compromised.	Iron	112-116	frataxin	Homo sapiens	163-167
24087894-0	2013	The effect of HFE polymorphisms on cardiac iron overload in patients with beta-thalassemia major.	Iron	43-47	homeostatic iron regulator	Homo sapiens	14-17
21720640-4	2011	The stability of the ligand and the Fe-complex is further examined by using thermogravimmetric/differential thermal analysis (TGA/DTA).	Iron	36-38	T-box transcription factor 1	Homo sapiens	126-129
22141280-3	2011	FRDA is characterized by a deficiency in frataxin, a protein vital in iron handling.	Iron	70-74	frataxin	Homo sapiens	41-49
22141280-4	2011	Iron accumulation, lack of functional iron-sulphur clusters, and oxidative stress seem to be among the most important consequences of frataxin deficiency explaining the cardiac abnormalities in FRDA.	Iron	0-4	frataxin	Homo sapiens	134-142
22141280-4	2011	Iron accumulation, lack of functional iron-sulphur clusters, and oxidative stress seem to be among the most important consequences of frataxin deficiency explaining the cardiac abnormalities in FRDA.	Iron	38-42	frataxin	Homo sapiens	134-142
21359952-12	2011	These results strongly implicate glucocorticoid receptor and STAT5 in stress-induced up-regulation of IRP-1, which subsequently enhances transferrin receptor-1 expression and down-regulates ferritin, causing iron accumulation in the liver.	Iron	208-212	aconitase 1	Rattus norvegicus	102-107
21632542-0	2011	Arabidopsis chloroplastic glutaredoxin C5 as a model to explore molecular determinants for iron-sulfur cluster binding into glutaredoxins.	Iron	91-95	Glutaredoxin family protein	Arabidopsis thaliana	26-41
24087894-1	2013	OBJECTIVE: We aimed to investigate the effect of human hemochromatosis protein (HFE) polymorphisms on cardiac iron overload in patients with beta-thalassemia major.	Iron	110-114	homeostatic iron regulator	Homo sapiens	80-83
21801864-12	2011	The findings herein suggest that ISCU down-regulation by miR-210 perturbing trophoblast iron metabolism is associated with defective placentation.	Iron	88-92	microRNA 210	Homo sapiens	57-64
24130867-10	2013	Podoplanin immunopositive lymphatic vessels were detected in the granulation tissue filling the fracture gap, surrounding the implant and growing into the iron foam through its interconnected pores.	Iron	155-159	podoplanin	Rattus norvegicus	0-10
21666526-2	2011	A single mutation of the HFE gene results in unregulated dietary iron uptake with the potential to deleteriously affect multiple organ systems including the eye.	Iron	65-69	homeostatic iron regulator	Homo sapiens	25-28
21676174-6	2011	Similar to the other RPE-specific RPE65, RPE65c was present in both the membrane and cytosolic fractions, used all-trans retinyl ester as its substrate and required iron for its enzymatic activity.	Iron	165-169	retinoid isomerohydrolase RPE65	Homo sapiens	34-39
21709601-2	2011	Heme oxygenase 2 (HMOX2) catalyzes the cleavage of the heme ring to form biliverdin with release of iron and carbon monoxide.	Iron	100-104	heme oxygenase 2	Homo sapiens	0-16
23800229-0	2013	The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron.	Iron	69-73	Rim2p	Saccharomyces cerevisiae S288C	26-30
21709601-2	2011	Heme oxygenase 2 (HMOX2) catalyzes the cleavage of the heme ring to form biliverdin with release of iron and carbon monoxide.	Iron	100-104	heme oxygenase 2	Homo sapiens	18-23
21676174-6	2011	Similar to the other RPE-specific RPE65, RPE65c was present in both the membrane and cytosolic fractions, used all-trans retinyl ester as its substrate and required iron for its enzymatic activity.	Iron	165-169	retinoid isomerohydrolase RPE65 c	Danio rerio	41-47
21334004-11	2011	To test for a possible genetic basis of increased iron uptake and storage in red deer, the cervid haemochromatosis gene (HFE) was identified.	Iron	50-54	homeostatic iron regulator	Homo sapiens	121-124
21334004-14	2011	Polymorphisms in other non-HFE genes involved in iron metabolism may have led to a higher sensitivity to iron and this, together with the high iron content of the drinking water, may have been the cause of the observed iron storage in these red deer.	Iron	49-53	homeostatic iron regulator	Homo sapiens	27-30
21334004-14	2011	Polymorphisms in other non-HFE genes involved in iron metabolism may have led to a higher sensitivity to iron and this, together with the high iron content of the drinking water, may have been the cause of the observed iron storage in these red deer.	Iron	105-109	homeostatic iron regulator	Homo sapiens	27-30
21334004-14	2011	Polymorphisms in other non-HFE genes involved in iron metabolism may have led to a higher sensitivity to iron and this, together with the high iron content of the drinking water, may have been the cause of the observed iron storage in these red deer.	Iron	105-109	homeostatic iron regulator	Homo sapiens	27-30
21849092-1	2011	BACKGROUND: Transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth.	Iron	117-121	transferrin receptor	Homo sapiens	12-32
21849092-1	2011	BACKGROUND: Transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth.	Iron	117-121	transferrin receptor	Homo sapiens	34-37
21801864-0	2011	miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies.	Iron	16-20	microRNA 210	Homo sapiens	0-7
21334004-14	2011	Polymorphisms in other non-HFE genes involved in iron metabolism may have led to a higher sensitivity to iron and this, together with the high iron content of the drinking water, may have been the cause of the observed iron storage in these red deer.	Iron	105-109	homeostatic iron regulator	Homo sapiens	27-30
23800229-3	2013	In Saccharomyces cerevisiae, overexpression of RIM2 (MRS12) encoding a mitochondrial pyrimidine nucleotide transporter can overcome the iron-related phenotypes of strains lacking both MRS3 and MRS4.	Iron	136-140	Rim2p	Saccharomyces cerevisiae S288C	47-51
23800229-4	2013	In the present study we show by in vitro transport studies that Rim2 mediates the transport of iron and other divalent metal ions across the mitochondrial inner membrane in a pyrimidine nucleotide-dependent fashion.	Iron	95-99	Rim2p	Saccharomyces cerevisiae S288C	64-68
23800229-6	2013	These results document that Rim2 catalyses the co-import of pyrimidine nucleotides and divalent metal ions including ferrous iron.	Iron	125-129	Rim2p	Saccharomyces cerevisiae S288C	28-32
23800229-8	2013	However, RIM2 deletion in mrs3/4Delta cells aggravates their Fe-S protein maturation defect.	Iron	61-65	Rim2p	Saccharomyces cerevisiae S288C	9-13
21807555-9	2011	TfR1 is upregulated as a result of iron sequestration during the acute-phase response to infection, and the severity of disease may result from amplification of viral replication during this response.	Iron	35-39	transferrin receptor	Homo sapiens	0-4
23504952-10	2013	These results suggest that the cellular internalization of IONP-PLL, much like iron ion, were mediated by TFR-dependent endocytosis and TFR-free uptake.	Iron	79-83	transferrin receptor	Homo sapiens	106-109
21281279-9	2011	CONCLUSIONS: Our study showed a clear association of body iron stores expressed by the TfR/F ratio with asymptomatic carotid atherosclerosis.	Iron	58-62	transferrin receptor	Homo sapiens	87-90
23504952-10	2013	These results suggest that the cellular internalization of IONP-PLL, much like iron ion, were mediated by TFR-dependent endocytosis and TFR-free uptake.	Iron	79-83	transferrin receptor	Homo sapiens	136-139
21654321-1	2011	BACKGROUND: HFE hemochromatosis (HFE-H) is the most common and well-defined inherited cause for iron-related morbidity and mortality.	Iron	96-100	homeostatic iron regulator	Homo sapiens	12-15
24018561-8	2013	Interestingly, urinary levels of the iron acceptor proteins neutrophil gelatinase-associated lipocalin, hemopexin, and transferrin were increased in FtH(PT-/-) mice after AKI.	Iron	37-41	lipocalin 2	Mus musculus	60-102
21654321-1	2011	BACKGROUND: HFE hemochromatosis (HFE-H) is the most common and well-defined inherited cause for iron-related morbidity and mortality.	Iron	96-100	homeostatic iron regulator	Homo sapiens	33-36
21654321-4	2011	However, the precise link between hepcidin levels and iron absorption in HFE-H patients has been poorly understood.	Iron	54-58	homeostatic iron regulator	Homo sapiens	73-76
21654321-5	2011	AIM: To measure hepcidin response to oral iron challenge (200 mg ferrous sulphate), in HFE-H (C282Y/C282Y) patients and compare with healthy controls (HCs).	Iron	42-46	homeostatic iron regulator	Homo sapiens	87-90
21654321-7	2011	All HFE-H were iron depleted and studied at a time distant to phlebotomy.	Iron	15-19	homeostatic iron regulator	Homo sapiens	4-7
21654321-14	2011	CONCLUSION: Failure to mount a rapid hepcidin response to an oral iron challenge is the key mechanisms of iron accumulation despite prevailing excess body iron in patients with HFE-H with C282Y/C282Y mutation.	Iron	66-70	homeostatic iron regulator	Homo sapiens	177-180
23860686-1	2013	Phenylalanine hydroxylase (PAH) is a non-heme iron enzyme that catalyzes oxidation of phenylalanine to tyrosine, a reaction that must be kept under tight regulatory control.	Iron	46-50	phenylalanine hydroxylase	Homo sapiens	0-25
21576334-3	2011	The innate immune protein lipocalin 2 (Lcn2) is able to specifically bind Ent and disrupt iron acquisition.	Iron	90-94	lipocalin 2	Mus musculus	39-43
23860686-1	2013	Phenylalanine hydroxylase (PAH) is a non-heme iron enzyme that catalyzes oxidation of phenylalanine to tyrosine, a reaction that must be kept under tight regulatory control.	Iron	46-50	phenylalanine hydroxylase	Homo sapiens	27-30
23247927-1	2013	PURPOSE: [corrected] To assess the factors associated with risk of haemoconcentration at delivery, such as initial haemoglobin levels and alterations in the HFE gene, and its effect on low birth weight in pregnant women supplemented with moderate doses of iron.	Iron	256-260	homeostatic iron regulator	Homo sapiens	157-160
21716156-6	2011	It is also useful where there appears to be a discrepancy between HFE genotypes and iron studies, particularly in HFE heterozygotes.	Iron	84-88	homeostatic iron regulator	Homo sapiens	114-117
21113736-1	2011	Hemojuvelin, also known as RGMc, is encoded by hfe2 gene that plays an important role in iron homeostasis.	Iron	89-93	hemojuvelin BMP co-receptor	Danio rerio	0-11
21113736-1	2011	Hemojuvelin, also known as RGMc, is encoded by hfe2 gene that plays an important role in iron homeostasis.	Iron	89-93	hemojuvelin BMP co-receptor	Danio rerio	27-31
23247927-9	2013	CONCLUSIONS: Moderate daily doses of supplementary iron may be harmful for foetal growth in women with alterations in HFE gene and who started pregnancy with good haemoglobin levels.	Iron	51-55	homeostatic iron regulator	Homo sapiens	118-121
21113736-1	2011	Hemojuvelin, also known as RGMc, is encoded by hfe2 gene that plays an important role in iron homeostasis.	Iron	89-93	hemojuvelin BMP co-receptor	Danio rerio	47-51
23794717-7	2013	RESULTS: We found that HFE rs1800562 and TMPRSS6 rs855791 are the main determinants of HFE and TMPRSS6 related variation in serum iron, ferritin, transferrin saturation, and total iron binding capacity.	Iron	180-184	homeostatic iron regulator	Homo sapiens	87-90
23794717-11	2013	Taken together, this suggests that there might be other, yet unknown, serum hepcidin independent mechanisms which play a role in the association of HFE and TMPRSS6 variants with serum iron parameters.	Iron	184-188	homeostatic iron regulator	Homo sapiens	148-151
23983424-8	2013	Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.	Iron	0-4	HCC	Homo sapiens	82-85
21488083-6	2011	Hepatic inhibitory Smad7 mRNA expression is increased by both acute and chronic iron administration and mirrors overall activation of the Smad1/5/8 signaling cascade.	Iron	80-84	SMAD family member 7	Mus musculus	19-24
21570952-7	2011	The reduction in cytosolic aconitase activity was associated with an increase in iron regulatory protein (IRP) mRNA binding activity and with an increase in the cytoplasmic labile iron pool.	Iron	81-85	Wnt family member 2	Homo sapiens	106-109
21570952-8	2011	Since IRP activity post-transcriptionally regulates the expression of iron import proteins, Fe-S cluster inhibition may result in a false iron deficiency signal.	Iron	70-74	Wnt family member 2	Homo sapiens	6-9
23685131-8	2013	Furthermore, iron treatments increase the levels of FTL, PEN-2 and PS1 NTF and promote gamma-secretase-mediated NICD production.	Iron	13-17	taste 2 receptor member 62 pseudogene	Homo sapiens	67-70
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	181-185	transferrin receptor	Homo sapiens	285-289
23814049-1	2013	Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins.	Iron	78-82	cytochrome b reductase 1	Rattus norvegicus	143-148
21669570-3	2011	HFE gene mutations may be involved in the pathogenesis of liver iron overload and influence the progression of chronic liver diseases of different origins.	Iron	64-68	homeostatic iron regulator	Homo sapiens	0-3
21669570-4	2011	This study was designed to determine the prevalence of iron overload in relation to HFE gene mutations among Polish patients with liver cirrhosis.	Iron	55-59	homeostatic iron regulator	Homo sapiens	84-87
23814049-1	2013	Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins.	Iron	123-127	cytochrome b reductase 1	Rattus norvegicus	143-148
21308772-0	2011	Inhibitory effects of iron on bone morphogenetic protein 2-induced osteoblastogenesis.	Iron	22-26	bone morphogenetic protein 2	Homo sapiens	30-58
23788639-0	2013	Arabidopsis ferritin 1 (AtFer1) gene regulation by the phosphate starvation response 1 (AtPHR1) transcription factor reveals a direct molecular link between iron and phosphate homeostasis.	Iron	157-161	photolyase 1	Arabidopsis thaliana	88-94
21308772-8	2011	Moreover, iron downregulated mRNA levels of several other osteoblastogenic markers such as Runx2, osterix, osteopontin, and osteocalcin.	Iron	10-14	Sp7 transcription factor	Homo sapiens	98-105
21308772-10	2011	Although iron inhibited preosteoblast cell differentiation, it did enhance preosteoblast cell proliferation, as evidenced by increased cell growth and expression of cell cycle regulator genes such as CDK4, CDK6, cyclin D1, and cyclin D3 and G(2) /M phase cell population.	Iron	9-13	cyclin dependent kinase 4	Homo sapiens	200-204
23788639-6	2013	Histochemical localization of iron, visualized by Perls DAB staining, was strongly altered in a phr1 phl1 mutant, revealing that both PHR1 and PHL1 are major factors involved in the regulation of iron homeostasis.	Iron	30-34	photolyase 1	Arabidopsis thaliana	96-105
23788639-6	2013	Histochemical localization of iron, visualized by Perls DAB staining, was strongly altered in a phr1 phl1 mutant, revealing that both PHR1 and PHL1 are major factors involved in the regulation of iron homeostasis.	Iron	30-34	photolyase 1	Arabidopsis thaliana	134-138
23788639-6	2013	Histochemical localization of iron, visualized by Perls DAB staining, was strongly altered in a phr1 phl1 mutant, revealing that both PHR1 and PHL1 are major factors involved in the regulation of iron homeostasis.	Iron	196-200	photolyase 1	Arabidopsis thaliana	96-105
21276436-5	2011	Cytotoxicity was attributed to increased NADH levels caused by CH(3)OH metabolism, catalyzed by ADH1, resulting in reductive stress, which reduced and released ferrous iron from Ferritin causing oxygen activation.	Iron	168-172	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	96-100
23791636-9	2013	p65 (RelA) NF-kappaB levels were increased in nuclear fractions from retinas exposed to iron.	Iron	88-92	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-3
23791636-9	2013	p65 (RelA) NF-kappaB levels were increased in nuclear fractions from retinas exposed to iron.	Iron	88-92	RELA proto-oncogene, NF-kB subunit	Homo sapiens	5-9
20669231-2	2011	Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system.	Iron	9-13	transferrin receptor	Homo sapiens	41-61
20669231-2	2011	Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system.	Iron	9-13	homeostatic iron regulator	Homo sapiens	70-85
20669231-2	2011	Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system.	Iron	9-13	homeostatic iron regulator	Homo sapiens	95-98
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	5-9	transferrin receptor	Homo sapiens	123-145
21397244-3	2011	BET results showed a significant increase in the surface area of the matrix following iron loading, implying that a porous nanomagnetite layer was formed.	Iron	86-90	delta/notch like EGF repeat containing	Homo sapiens	0-3
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	5-9	transferrin receptor	Homo sapiens	147-151
23508576-3	2013	To test the hypothesis that DMT1 is required for hepatic iron uptake, we examined mice with the Dmt1 gene selectively inactivated in hepatocytes (Dmt1(liv/liv) ).	Iron	57-61	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	28-32
23838697-2	2013	Neutrophil gelatinase-associated lipocalin (NGAL) has 2 functions: one as an antibacterial host defense protein and the other as a physiological iron carrier.	Iron	145-149	hyaluronan synthase 2	Homo sapiens	50-55
21586684-0	2011	Interaction between the bHLH transcription factor FIT and ETHYLENE INSENSITIVE3/ETHYLENE INSENSITIVE3-LIKE1 reveals molecular linkage between the regulation of iron acquisition and ethylene signaling in Arabidopsis.	Iron	160-164	Ethylene insensitive 3 family protein	Arabidopsis thaliana	58-79
23859340-3	2013	Frataxin is a highly conserved iron-binding protein present in most organisms.	Iron	31-35	frataxin	Homo sapiens	0-8
23859340-6	2013	The picture that emerges is that frataxin is a crucial element of one of the most essential cellular machines specialized in iron-sulfur cluster biogenesis.	Iron	125-129	frataxin	Homo sapiens	33-41
21691434-2	2011	It is a mitochondrial disease caused by severely reduced expression of the iron binding protein, frataxin.	Iron	75-79	frataxin	Homo sapiens	97-105
23859348-2	2013	The underlying cause is a deficiency of the mitochondrial protein frataxin which causes mitochondrial iron deposition, increased oxidative stress and impaired adenosine triphosphate production.	Iron	102-106	frataxin	Homo sapiens	66-74
23759098-5	2013	Whereas atnas4 had normal growth in iron-sufficient medium, it displayed a reduced accumulation of ferritins and exhibited a hypersensitivity to iron deficiency.	Iron	36-40	nicotianamine synthase 4	Arabidopsis thaliana	8-14
21315377-14	2011	The role of frataxin deficiency in the pathogenesis of FRDA is still unclear because the protein has multiple functions in the normal state, including biogenesis of iron-sulfur clusters; iron chaperoning; iron storage; and control of iron-mediated oxidative tissue damage.	Iron	165-169	frataxin	Homo sapiens	12-20
21315377-14	2011	The role of frataxin deficiency in the pathogenesis of FRDA is still unclear because the protein has multiple functions in the normal state, including biogenesis of iron-sulfur clusters; iron chaperoning; iron storage; and control of iron-mediated oxidative tissue damage.	Iron	187-191	frataxin	Homo sapiens	12-20
21315377-14	2011	The role of frataxin deficiency in the pathogenesis of FRDA is still unclear because the protein has multiple functions in the normal state, including biogenesis of iron-sulfur clusters; iron chaperoning; iron storage; and control of iron-mediated oxidative tissue damage.	Iron	187-191	frataxin	Homo sapiens	12-20
21315377-14	2011	The role of frataxin deficiency in the pathogenesis of FRDA is still unclear because the protein has multiple functions in the normal state, including biogenesis of iron-sulfur clusters; iron chaperoning; iron storage; and control of iron-mediated oxidative tissue damage.	Iron	187-191	frataxin	Homo sapiens	12-20
23759098-7	2013	Under iron deficiency, atnas4 displayed a lower expression of the iron uptake-related genes IRT1 and FRO2 as well as a reduced ferric reductase activity.	Iron	6-10	nicotianamine synthase 4	Arabidopsis thaliana	23-29
23759098-7	2013	Under iron deficiency, atnas4 displayed a lower expression of the iron uptake-related genes IRT1 and FRO2 as well as a reduced ferric reductase activity.	Iron	6-10	ferric reduction oxidase 2	Arabidopsis thaliana	101-105
21316847-1	2011	This study simulated benzene and toluene biodegradation down gradient of a zero-valent iron permeable reactive barrier (ZVI PRB) that reduces trichloroethylene (TCE).	Iron	87-91	RB transcriptional corepressor 1	Homo sapiens	124-127
21804464-5	2011	Heme oxygenase-2 is capable of degradation of heme producing free iron ions, thus, diversity in heme oxygenase-2 gene may contribute to AMD.	Iron	66-70	heme oxygenase 2	Homo sapiens	0-16
21316847-6	2011	These results suggest that, at least for cis-1,2-DCE, its formation may not be toxic to iron-reducing benzene and toluene degrading bacteria; however, for microbial benzene and toluene removal down gradient of a ZVI PRB, it may be necessary to provide pH control, especially in the case of a biological PRB that is downstream from a ZVI PRB.	Iron	212-215	RB transcriptional corepressor 1	Homo sapiens	216-219
21804464-5	2011	Heme oxygenase-2 is capable of degradation of heme producing free iron ions, thus, diversity in heme oxygenase-2 gene may contribute to AMD.	Iron	66-70	heme oxygenase 2	Homo sapiens	96-112
23759098-9	2013	Collectively, our data, together with recent studies, support the hypothesis that AtNAS4 displays an important role in iron distribution and is required for proper response to iron deficiency and to cadmium supply.	Iron	119-123	nicotianamine synthase 4	Arabidopsis thaliana	82-88
21316847-6	2011	These results suggest that, at least for cis-1,2-DCE, its formation may not be toxic to iron-reducing benzene and toluene degrading bacteria; however, for microbial benzene and toluene removal down gradient of a ZVI PRB, it may be necessary to provide pH control, especially in the case of a biological PRB that is downstream from a ZVI PRB.	Iron	212-215	RB transcriptional corepressor 1	Homo sapiens	303-306
21316847-6	2011	These results suggest that, at least for cis-1,2-DCE, its formation may not be toxic to iron-reducing benzene and toluene degrading bacteria; however, for microbial benzene and toluene removal down gradient of a ZVI PRB, it may be necessary to provide pH control, especially in the case of a biological PRB that is downstream from a ZVI PRB.	Iron	212-215	RB transcriptional corepressor 1	Homo sapiens	303-306
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	113-117	homeostatic iron regulator	Homo sapiens	309-312
21671584-0	2011	Friedreich"s ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex.	Iron	87-91	frataxin	Homo sapiens	54-62
21671584-7	2011	The Fxn variants also have diminished ability to function as part of the SDUF complex to stimulate the cysteine desulfurase reaction and facilitate Fe-S cluster assembly.	Iron	148-152	frataxin	Homo sapiens	4-7
21671584-8	2011	Four crystal structures, including the first for a FRDA variant, reveal specific rearrangements associated with the loss of function and lead to a model for Fxn-based activation of the Fe-S cluster assembly complex.	Iron	185-187	frataxin	Homo sapiens	157-160
21671584-10	2011	Together, these results suggest that Fxn facilitates sulfur transfer from Nfs1 to Isu2 and that these in vitro assays are sensitive and appropriate for deciphering functional defects and mechanistic details for human Fe-S cluster biosynthesis.	Iron	217-221	frataxin	Homo sapiens	37-40
21671584-10	2011	Together, these results suggest that Fxn facilitates sulfur transfer from Nfs1 to Isu2 and that these in vitro assays are sensitive and appropriate for deciphering functional defects and mechanistic details for human Fe-S cluster biosynthesis.	Iron	217-221	NFS1 cysteine desulfurase	Homo sapiens	74-78
21349849-2	2011	Mutations of HFE are best known as being associated with cellular iron overload, but the mechanism by which HFE H63D might increase the risk of neuron degeneration is unclear.	Iron	66-70	homeostatic iron regulator	Homo sapiens	13-16
21346306-6	2011	After 4 h of incubation with 100-4000 microM iron supplied as Fe-NP, the cellular iron content reached levels between 200 and 2000 nmol mg-1 protein.	Iron	45-49	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	136-140
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	185-189	homeostatic iron regulator	Homo sapiens	309-312
21346306-6	2011	After 4 h of incubation with 100-4000 microM iron supplied as Fe-NP, the cellular iron content reached levels between 200 and 2000 nmol mg-1 protein.	Iron	82-86	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	136-140
23846788-6	2013	To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin).	Iron	185-189	homeostatic iron regulator	Homo sapiens	309-312
22093897-11	2011	CONCLUSION: IRP2 may affect the expressions of TfR and Fn in lung adenocarcinoma A549 cells by changing the amount of protein and regulating the iron metabolism.	Iron	145-149	transferrin receptor	Homo sapiens	47-50
23847632-4	2013	In wheat, one member of the NAC (NAM, ATAF, and CUC) transcription factor (TF) family (NAM-B1) has a major role in the process, probably regulating key genes for the early onset of senescence, which results in higher Fe and Zn concentrations in grains.	Iron	217-219	NAC domain-containing protein 20	Triticum aestivum	33-36
21622652-7	2011	Finally, we show that, in mice, Tmprss6 mRNA expression is stimulated by chronic iron treatment or BMP6 injection and is blocked by injection of neutralizing antibody against BMP6.	Iron	81-85	transmembrane serine protease 6	Mus musculus	32-39
21654517-2	2011	This cytotoxicity is attributed to its ability to decrease the level of TfR1 leading to lethal iron deprivation.	Iron	95-99	transferrin receptor	Homo sapiens	72-76
21292994-0	2011	Iron loading and oxidative stress in the Atm-/- mouse liver.	Iron	0-4	ataxia telangiectasia mutated	Mus musculus	41-44
21292994-6	2011	Atm(-/-) mice had increased serum iron, hepatic iron, and ferritin and significantly higher Hepcidin compared with wild-type mice.	Iron	34-38	ataxia telangiectasia mutated	Mus musculus	0-3
21292994-6	2011	Atm(-/-) mice had increased serum iron, hepatic iron, and ferritin and significantly higher Hepcidin compared with wild-type mice.	Iron	48-52	ataxia telangiectasia mutated	Mus musculus	0-3
21292994-8	2011	Atm(-/-) mice had increased protein tyrosine nitration and significantly higher Heme Oxygenase (decycling) 1 levels that were substantially increased by a high-iron diet.	Iron	160-164	ataxia telangiectasia mutated	Mus musculus	0-3
21292994-10	2011	We demonstrate that Atm(-/-) mice have a propensity to accumulate iron that is associated with a significant increase in hepatic OS.	Iron	66-70	ataxia telangiectasia mutated	Mus musculus	20-23
23847632-4	2013	In wheat, one member of the NAC (NAM, ATAF, and CUC) transcription factor (TF) family (NAM-B1) has a major role in the process, probably regulating key genes for the early onset of senescence, which results in higher Fe and Zn concentrations in grains.	Iron	217-219	NAC domain-containing protein 20	Triticum aestivum	87-90
23585563-0	2013	IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.	Iron	61-65	cytosolic iron-sulfur assembly component 3	Homo sapiens	0-4
21213119-2	2011	Neuronal iron uptake is reflected in a robust and consistent expression of transferrin receptors and divalent metal transporter 1 (DMT 1).	Iron	9-13	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	101-129
21213119-2	2011	Neuronal iron uptake is reflected in a robust and consistent expression of transferrin receptors and divalent metal transporter 1 (DMT 1).	Iron	9-13	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	131-136
21542867-1	2011	Saccharomyces cerevisiae can import iron through a high-affinity system consisting of the Ftr1/Fet3-mediated reductive pathway and the siderophore-mediated non-reductive one.	Iron	36-40	ferroxidase FET3	Saccharomyces cerevisiae S288C	95-99
21542867-9	2011	This reinforces the idea that upon oxidative stress S. cerevisiae cells redirect iron assimilation through the non-reductive pathway to minimize oxidative damage by the ferrous ions, which are formed during iron import through the Ftr1/Fet3 complexes.	Iron	81-85	ferroxidase FET3	Saccharomyces cerevisiae S288C	236-240
21542867-9	2011	This reinforces the idea that upon oxidative stress S. cerevisiae cells redirect iron assimilation through the non-reductive pathway to minimize oxidative damage by the ferrous ions, which are formed during iron import through the Ftr1/Fet3 complexes.	Iron	207-211	ferroxidase FET3	Saccharomyces cerevisiae S288C	236-240
23741765-3	2004	The TF receptor (TFRC) mediates the internalization of iron-loaded TF into cells (1, 2).	Iron	55-59	transferrin receptor	Mus musculus	4-15
21440626-0	2011	Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.	Iron	52-56	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
21440626-1	2011	Cellular and organismal iron storage depends on the function of the ferritin protein complex in insects and mammals alike.	Iron	24-28	Ferritin 1 heavy chain homologue	Drosophila melanogaster	68-76
21427356-4	2011	beta2-M interacts with its receptor, hemochromatosis (HFE) protein, to modulate iron responsive pathways in cancer cells.	Iron	80-84	beta-2 microglobulin	Mus musculus	0-7
23741765-3	2004	The TF receptor (TFRC) mediates the internalization of iron-loaded TF into cells (1, 2).	Iron	55-59	transferrin receptor	Mus musculus	17-21
21440626-4	2011	Anatomical analysis of the affected brains revealed crystalline inclusions of iron-loaded ferritin in a subpopulation of glial cells but not significant neurodegeneration.	Iron	78-82	Ferritin 1 heavy chain homologue	Drosophila melanogaster	90-98
21499539-5	2011	This review summarizes some key structural and functional properties of three central proteins dedicated to the Fe-S cluster assembly process: namely, the sulfide donor (cysteine desulfurase); iron donor (frataxin), and the iron-sulfur cluster scaffold protein (IscU/ISU).	Iron	112-116	frataxin	Homo sapiens	205-213
23518448-2	2013	ACO2 was selected for this study because (1) it is known to be inactivated by HNE, (2) elevated concentrations of HNE-adducted ACO2 have been associated with disease states, (3) extensive structural information is available, and (4) the iron-sulfur cluster in ACO2 offers a critical target for HNE adduction.	Iron	237-241	elastase, neutrophil expressed	Homo sapiens	114-117
21235714-6	2011	Similar to RPE65, 13cIMH is a membrane-associated protein, requires all-trans retinyl ester as its intrinsic substrate, and its enzymatic activity is dependent on iron.	Iron	163-167	retinoid isomerohydrolase RPE65	Homo sapiens	11-16
21791187-7	2011	TLC has a variety of suggested functions in tears, including regulation of tear viscosity, binding and release of lipids, endonuclease inactivation of viral DNA, binding of microbial siderophores (iron chelators used to deliver essential iron to bacteria), serving as a biomarker for dry eye, and possessing anti-inflammatory activity.	Iron	197-201	lipocalin 1	Homo sapiens	0-3
21791187-7	2011	TLC has a variety of suggested functions in tears, including regulation of tear viscosity, binding and release of lipids, endonuclease inactivation of viral DNA, binding of microbial siderophores (iron chelators used to deliver essential iron to bacteria), serving as a biomarker for dry eye, and possessing anti-inflammatory activity.	Iron	238-242	lipocalin 1	Homo sapiens	0-3
23518448-2	2013	ACO2 was selected for this study because (1) it is known to be inactivated by HNE, (2) elevated concentrations of HNE-adducted ACO2 have been associated with disease states, (3) extensive structural information is available, and (4) the iron-sulfur cluster in ACO2 offers a critical target for HNE adduction.	Iron	237-241	elastase, neutrophil expressed	Homo sapiens	114-117
21173098-0	2011	A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.	Iron	38-42	homeostatic iron regulator	Homo sapiens	70-73
21464130-3	2011	Studies in yeast, mammalian cells, and mice have shown that ABCB7 functions in the transport of iron-sulfur (Fe-S) clusters into the cytoplasm.	Iron	109-113	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	60-65
23605050-0	2013	Effects of high iron and glucose concentrations over the relative expression of Bcl2, Bax, and Mfn2 in MIN6 cells.	Iron	16-20	mitofusin 2	Mus musculus	95-99
21514188-4	2011	We propose that other Sp6 orthologues may be involved in the genetic response to increase iron absorption, possibly in co-operation with hypoxia inducible factor 2 alpha (HIF-2alpha)-a newly discovered regulator of iron absorption.	Iron	90-94	trans-acting transcription factor 6	Mus musculus	22-25
21514188-4	2011	We propose that other Sp6 orthologues may be involved in the genetic response to increase iron absorption, possibly in co-operation with hypoxia inducible factor 2 alpha (HIF-2alpha)-a newly discovered regulator of iron absorption.	Iron	215-219	trans-acting transcription factor 6	Mus musculus	22-25
21392187-0	2011	Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation.	Iron	59-63	transferrin receptor	Homo sapiens	90-110
21392187-5	2011	While the recycling route and iron-regulated expression of TfR are well characterized, the mechanism by which the degradation of TfR is regulated is largely unknown.	Iron	30-34	transferrin receptor	Homo sapiens	59-62
21392187-6	2011	We show that an excess of iron enhances both TfR"s ubiquitylation and degradation in lysosomes.	Iron	26-30	transferrin receptor	Homo sapiens	45-48
21392187-7	2011	Probably, the up-regulated expression of ferritin, an endogenous iron-chelating molecule, attenuated the iron-induced degradation of TfR.	Iron	65-69	transferrin receptor	Homo sapiens	133-136
23605050-3	2013	The purpose of this study was to describe the effect of different iron and/or glucose concentrations over Mfn2, Bax, and Bcl2 expressions in a beta-pancreatic cell line (MIN6 cells).	Iron	66-70	mitofusin 2	Mus musculus	106-110
21392187-7	2011	Probably, the up-regulated expression of ferritin, an endogenous iron-chelating molecule, attenuated the iron-induced degradation of TfR.	Iron	105-109	transferrin receptor	Homo sapiens	133-136
23180044-1	2013	BACKGROUND: The mitochondrial protein frataxin regulates iron metabolism for heme and iron sulfur cluster synthesis in the mitochondria and could be associated with the regulation of oxidative stress.	Iron	57-61	frataxin	Homo sapiens	38-46
21392187-8	2011	Exogenously introduced lysine-less TfR, compared to the wild-type one, showed resistance to the iron-induced ubiquitylation and degradation, when endogenous TfR, which most certainly heterodimerizes with exogenous ones, was depleted with siRNA.	Iron	96-100	transferrin receptor	Homo sapiens	35-38
21392187-8	2011	Exogenously introduced lysine-less TfR, compared to the wild-type one, showed resistance to the iron-induced ubiquitylation and degradation, when endogenous TfR, which most certainly heterodimerizes with exogenous ones, was depleted with siRNA.	Iron	96-100	transferrin receptor	Homo sapiens	157-160
21392187-9	2011	These data suggest that the iron-induced ubiquitylation and degradation of TfR along with MVB pathway physiologically plays an important role in iron homeostasis.	Iron	28-32	transferrin receptor	Homo sapiens	75-78
21392187-9	2011	These data suggest that the iron-induced ubiquitylation and degradation of TfR along with MVB pathway physiologically plays an important role in iron homeostasis.	Iron	145-149	transferrin receptor	Homo sapiens	75-78
21796974-0	2011	Role of HFE gene mutations on developing iron overload in beta-thalassaemia carriers in Egypt.	Iron	41-45	homeostatic iron regulator	Homo sapiens	8-11
21796974-3	2011	The iron status in these subjects was studied and correlated with the HFE gene mutations.	Iron	4-8	homeostatic iron regulator	Homo sapiens	70-73
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Iron	33-35	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
21534614-10	2011	We, therefore, have characterized some of these neuronal nitric oxide synthase (nNOS)-thioether inhibitor complexes in both crystal and solution using EPR and UV-visible absorption spectrometry as a function of temperature and the heme iron redox state.	Iron	236-240	nitric oxide synthase 1	Homo sapiens	80-84
21267610-8	2011	We conclude that the residue type at position 51/52 in the cytochrome c(6) family is additionally responsible for tuning the stability of the heme iron-Met bond and the dynamic properties of the ferric protein fold associated with endogenous ligand binding.	Iron	147-151	Cytochrome c	Arabidopsis thaliana	59-71
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Iron	189-191	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
20401695-1	2011	Stearoyl-CoA desaturase (SCD) is an iron-containing enzyme involving in the biosynthesis of monounsaturated fatty acids (MUFA) in mammary gland and adipose tissue, while decorin (DCN) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain, contributing multifunctionally to matrix assembly, modulation of the activity of growth factors and cell migration and proliferation.	Iron	36-40	decorin	Capra hircus	170-177
20401695-1	2011	Stearoyl-CoA desaturase (SCD) is an iron-containing enzyme involving in the biosynthesis of monounsaturated fatty acids (MUFA) in mammary gland and adipose tissue, while decorin (DCN) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain, contributing multifunctionally to matrix assembly, modulation of the activity of growth factors and cell migration and proliferation.	Iron	36-40	decorin	Capra hircus	179-182
21191310-9	2011	Duodenal cytochrome b (Dcyt-b), divalent metal transporter 1 (DMT-1), and ferroportin are the crucial regulators of intestinal iron transport and absorption.	Iron	127-131	cytochrome b reductase 1	Rattus norvegicus	23-29
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	162-190
21248200-1	2011	Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis.	Iron	102-106	solute carrier family 25 member 37	Danio rerio	0-12
21248200-1	2011	Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis.	Iron	102-106	solute carrier family 25 member 37	Danio rerio	14-19
21248200-1	2011	Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis.	Iron	102-106	solute carrier family 25 member 37	Danio rerio	21-29
21384276-2	2011	The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF).	Iron	138-142	homeostatic iron regulator	Homo sapiens	30-33
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	162-190
21384276-2	2011	The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF).	Iron	138-142	homeostatic iron regulator	Homo sapiens	47-50
21384276-2	2011	The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF).	Iron	138-142	transferrin receptor	Homo sapiens	84-104
23136396-2	2013	FRDA is due to expanded GAA repeats within the first intron of the gene encoding frataxin, a conserved mitochondrial protein involved in iron-sulphur cluster biosynthesis.	Iron	137-141	frataxin	Homo sapiens	81-89
21384276-2	2011	The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF).	Iron	138-142	transferrin receptor	Homo sapiens	106-109
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	79-83	aconitase 1	Homo sapiens	105-109
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	79-83	aconitase 1	Homo sapiens	105-109
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	79-83	aconitase 1	Homo sapiens	105-109
20383623-7	2011	Due to the predicted iron responsive element (IRE) in the 5"-untranslated region of the human alpha-synuclein mRNA contains, we observed that alpha-synuclein mRNA level was up-regulated in SK-N-SH cells with iron regulatory protein (IRP) knockdown and more alpha-synuclein aggregations were observed in cells.	Iron	21-25	Wnt family member 2	Homo sapiens	208-231
20383623-7	2011	Due to the predicted iron responsive element (IRE) in the 5"-untranslated region of the human alpha-synuclein mRNA contains, we observed that alpha-synuclein mRNA level was up-regulated in SK-N-SH cells with iron regulatory protein (IRP) knockdown and more alpha-synuclein aggregations were observed in cells.	Iron	21-25	Wnt family member 2	Homo sapiens	233-236
20383623-8	2011	The results suggest that iron-induced intracellular aggregated alpha-synuclein is partially dependent on oxidative stress and iron might also regulate alpha-synuclein aggregation through the IRE/IRP system.	Iron	25-29	Wnt family member 2	Homo sapiens	195-198
20383623-8	2011	The results suggest that iron-induced intracellular aggregated alpha-synuclein is partially dependent on oxidative stress and iron might also regulate alpha-synuclein aggregation through the IRE/IRP system.	Iron	126-130	Wnt family member 2	Homo sapiens	195-198
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	206-210	transferrin receptor	Homo sapiens	85-105
21333694-7	2011	The changed ferritin content coupled to TfR-1 induction after TCDD exposure impairs the cellular iron homeostasis, ultimately leading to significant changes in the labile iron pool (LIP) extent.	Iron	97-101	transferrin receptor	Homo sapiens	40-45
21333694-7	2011	The changed ferritin content coupled to TfR-1 induction after TCDD exposure impairs the cellular iron homeostasis, ultimately leading to significant changes in the labile iron pool (LIP) extent.	Iron	171-175	transferrin receptor	Homo sapiens	40-45
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	0-4	aconitase 1	Homo sapiens	24-28
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	0-4	nuclear respiratory factor 1	Homo sapiens	99-113
23543755-3	2013	It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden siderophores to attenuate bacterial growth.	Iron	149-153	lipocalin 2	Mus musculus	58-62
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	180-184	aconitase 1	Homo sapiens	24-28
21185934-4	2011	Iron-response proteins (IRP1 and IRP2) and "cap-n-collar" bZIP transcriptional factors (NE-F2 p45; Nrf1, 2, and 3; Bach1 and 2) also control gene and protein expression of the key iron homeostasis proteins.	Iron	180-184	nuclear respiratory factor 1	Homo sapiens	99-113
21208937-2	2011	Meta-analysis of two genome-wide association (GWA) studies and replication in three independent cohorts was performed to identify genetic loci associated in the general population with serum levels of iron and markers of iron status, including transferrin, ferritin, soluble transferrin receptor (sTfR) and sTfR-ferritin index.	Iron	201-205	transferrin receptor	Homo sapiens	275-295
21385868-8	2011	Genes of the Aft1p-dependent iron regulon were induced specifically in the absence of Prx1p despite optimal mitochondrial Fe-S biogenesis, suggesting dysfunction of the mitochondria to the cytosol signaling pathway.	Iron	29-33	thioredoxin peroxidase PRX1	Saccharomyces cerevisiae S288C	86-91
21385868-9	2011	Strikingly, requirement of Grx2p for these events places dithiolic Grx2 in the framework of iron metabolism.	Iron	92-96	dithiol glutaredoxin GRX2	Saccharomyces cerevisiae S288C	27-32
21385868-9	2011	Strikingly, requirement of Grx2p for these events places dithiolic Grx2 in the framework of iron metabolism.	Iron	92-96	dithiol glutaredoxin GRX2	Saccharomyces cerevisiae S288C	27-31
21501491-1	2011	BACKGROUND: The SLC11A1/Nramp1 and SLC11A2/Nramp2 genes belong to the SLC11/Nramp family of transmembrane divalent metal transporters, with SLC11A1 being associated with resistance to pathogens and SLC11A2 involved in intestinal iron uptake and transferrin-bound iron transport.	Iron	229-233	solute carrier family 34 member 1	Homo sapiens	16-21
21501491-1	2011	BACKGROUND: The SLC11A1/Nramp1 and SLC11A2/Nramp2 genes belong to the SLC11/Nramp family of transmembrane divalent metal transporters, with SLC11A1 being associated with resistance to pathogens and SLC11A2 involved in intestinal iron uptake and transferrin-bound iron transport.	Iron	263-267	solute carrier family 34 member 1	Homo sapiens	16-21
23543755-3	2013	It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden siderophores to attenuate bacterial growth.	Iron	149-153	lipocalin 2	Mus musculus	103-107
21501491-10	2011	This study provides, to our knowledge, the first example of this type of sub-functionalization in iron metabolism genes, illustrating how conserving the various functions of the SLC11 gene family is of crucial evolutionary importance.	Iron	98-102	solute carrier family 34 member 1	Homo sapiens	178-183
21363917-2	2011	Discoveries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have provided specificity and molecular definition to the role of iron homeostasis in cancer growth and metastasis.	Iron	148-152	Wnt family member 2	Homo sapiens	173-176
23536430-4	2013	Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/beta-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm.	Iron	162-166	VPS35 retromer complex component	Homo sapiens	20-25
20957368-1	2011	CyaY is the bacterial homolog of frataxin, proposed to be involved in the assembly of iron-sulfur clusters.	Iron	86-90	frataxin	Homo sapiens	0-4
20957368-4	2011	The CyaY protein can bind ferric iron and serve as an iron donor for the biogenesis of iron-sulfur clusters on the scaffold protein IscU in the presence of IscS and L-cysteine in vitro.	Iron	33-37	frataxin	Homo sapiens	4-8
21365094-5	2011	From the transmittance spectra, the fundamental absorption edge is found to be decreased with the Fe composition due to the joint contributions from SnO(2) and Fe(2)O(3).	Iron	98-100	strawberry notch homolog 1	Homo sapiens	149-152
23536430-4	2013	Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/beta-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm.	Iron	171-175	VPS35 retromer complex component	Homo sapiens	20-25
21229381-5	2011	Utilizing immuno-spin trapping in protein fractions that were rich in iron, we tentatively indentified protein carrier(s) of ferrous iron by MALDI-TOF MS. One of the identified proteins was the metalloproteinase (MMP) inhibitor, TIMP-2.	Iron	133-137	matrix metallopeptidase 2	Rattus norvegicus	213-216
21175851-8	2011	The patient presented a mild iron overload phenotype probably because of the two novel mutations in the HFE and SLC40A1 genes.	Iron	29-33	homeostatic iron regulator	Homo sapiens	104-107
23688756-12	2013	The apoptosis of erythrocytes and stem cells coated with auto-antibodies in BM of iron overloading IRP patients were significantly higher than those of non-iron overloading IRP and normal controls.	Iron	82-86	Wnt family member 2	Homo sapiens	99-102
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	56-60	Wnt family member 2	Homo sapiens	358-361
21147271-2	2011	The gene product called frataxin, a mitochondrial protein that is severely reduced in FRDA patients, leads to mitochondrial iron accumulation, Fe-S cluster deficiency and oxidative damage.	Iron	124-128	frataxin	Homo sapiens	24-32
21412944-0	2011	SNP and haplotype analysis reveals new HFE variants associated with iron overload trait.	Iron	68-72	homeostatic iron regulator	Homo sapiens	39-42
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	142-146	Wnt family member 2	Homo sapiens	358-361
21412944-1	2011	Hereditary hemochromatosis is a common-recessive-autosomal disease characterized by progressive iron overload, and its prevalence correlates with c.845G&gt;A (p. C282Y) mutation of the HFE gene.	Iron	96-100	homeostatic iron regulator	Homo sapiens	185-188
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	Iron	142-146	Wnt family member 2	Homo sapiens	358-361
21191310-9	2011	Duodenal cytochrome b (Dcyt-b), divalent metal transporter 1 (DMT-1), and ferroportin are the crucial regulators of intestinal iron transport and absorption.	Iron	127-131	cytochrome b reductase 1	Rattus norvegicus	0-21
20826742-7	2011	This could be traced back to increased phosphorylation of nuclear factor kappa-B p65 in monocytes following iron treatment, which was more pronounced when pre-treatment serum ferritin levels were low.	Iron	108-112	RELA proto-oncogene, NF-kB subunit	Homo sapiens	81-84
23579275-5	2013	There is a positive feed-forward loop between ROS generation and miR-210, and miR-210 itself increases ROS generation by downregulation of iron-sulfur cluster scaffold homolog 2 (ISCU2).	Iron	139-143	microRNA 210	Homo sapiens	65-72
21421810-7	2011	This perturbation of sphingolipid biosynthesis in the Arabidopsis tsc10a mutant leads an altered leaf ionome, including increases in Na, K, and Rb and decreases in Mg, Ca, Fe, and Mo.	Iron	172-174	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	66-72
21219335-9	2011	Overexpressing a ZIP family member IRT3 in irt1-1, rescues the Fe-deficient phenotype.	Iron	63-65	iron regulated transporter 3	Arabidopsis thaliana	35-39
21348856-7	2011	The present review summarizes basic concepts of iron transport, use and storage and focuses on the IRE (iron-responsive element)/IRP (iron-regulatory protein) system, a well known post-transcriptional regulatory circuit that not only maintains iron homoeostasis in various cell types, but also contributes to systemic iron balance.	Iron	48-52	Wnt family member 2	Homo sapiens	129-132
21348856-7	2011	The present review summarizes basic concepts of iron transport, use and storage and focuses on the IRE (iron-responsive element)/IRP (iron-regulatory protein) system, a well known post-transcriptional regulatory circuit that not only maintains iron homoeostasis in various cell types, but also contributes to systemic iron balance.	Iron	104-108	Wnt family member 2	Homo sapiens	129-132
21348856-7	2011	The present review summarizes basic concepts of iron transport, use and storage and focuses on the IRE (iron-responsive element)/IRP (iron-regulatory protein) system, a well known post-transcriptional regulatory circuit that not only maintains iron homoeostasis in various cell types, but also contributes to systemic iron balance.	Iron	104-108	Wnt family member 2	Homo sapiens	129-132
23579275-5	2013	There is a positive feed-forward loop between ROS generation and miR-210, and miR-210 itself increases ROS generation by downregulation of iron-sulfur cluster scaffold homolog 2 (ISCU2).	Iron	139-143	microRNA 210	Homo sapiens	78-85
23416150-0	2013	Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats.	Iron	8-12	lipocalin 2	Rattus norvegicus	22-33
21407826-1	2011	BACKGROUND: The pathophysiology of HFE-derived Hereditary Hemochromatosis and the function of HFE protein in iron homeostasis remain uncertain.	Iron	109-113	homeostatic iron regulator	Homo sapiens	94-97
21407826-13	2011	It could be either an agonist or antagonist of the full length HFE, through hepcidin expression regulation in the liver or by controlling dietary iron absorption in the duodenum.	Iron	146-150	homeostatic iron regulator	Homo sapiens	63-66
21331377-5	2011	Under iron-excess condition, a 6-fold increase in caspase-3 activity (P &lt; .001) and a 42% increase in DNA fragmentation (P &lt; .05) with 6-OHDA treatment were decreased by 41% (P &lt; .01) and 27% (P &lt; .05), respectively, with 30 mumol/L IP6.	Iron	6-10	caspase 3	Rattus norvegicus	50-59
20980142-4	2011	A combination of nitrogen deficiency, moderately high light intensity (82.5 muE m(-2) s(-1)) and high level of iron (0.74 mM) improved lipid accumulation in TRG, KB, SK, and PSU strains up to 35.9%, 30.2%, 28.4% and 14.7%, respectively.	Iron	111-115	T cell receptor gamma locus	Homo sapiens	157-160
23416150-2	2013	Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport.	Iron	75-79	lipocalin 2	Rattus norvegicus	0-11
21183736-3	2011	METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler.	Iron	37-41	homeostatic iron regulator	Homo sapiens	322-325
23416150-2	2013	Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport.	Iron	75-79	lipocalin 2	Rattus norvegicus	13-17
23416150-11	2013	Iron, but not saline injection also caused brain LCN2 upregulation (a more than 100-fold increase).	Iron	0-4	lipocalin 2	Rattus norvegicus	49-53
21150441-3	2011	New proteins (hepcidin, hemojuvelin, HFE, TFR2 and ferroportin), mutated in hereditary hemochromatosis, have been identified with a crucial role in iron regulation.	Iron	148-152	homeostatic iron regulator	Homo sapiens	37-40
23416150-13	2013	These results suggest that iron has a role in brain LCN2 upregulation following ICH.	Iron	27-31	lipocalin 2	Rattus norvegicus	52-56
21220026-1	2011	Ceruloplasmin is a serum ferroxidase that carries more than 90% of the copper in plasma and has documented roles in iron homeostasis as well as antioxidative functions.	Iron	116-120	LOC100533122	Ictalurus punctatus	0-13
23416150-14	2013	LCN2 upregulation after ICH may be part of the response to clear iron released from the hematoma during clot resolution.	Iron	65-69	lipocalin 2	Rattus norvegicus	0-4
21220026-4	2011	The objective of this study, therefore, was to characterize the ceruloplasmin gene from channel catfish, determine its genomic organization, profile its patterns of tissue expression, and establish its potential for physiological antioxidant responses in catfish after bacterial infection with E. ictaluri and iron treatment.	Iron	310-314	LOC100533122	Ictalurus punctatus	64-77
23416510-4	2013	OBJECTIVES: We evaluated the impact of iron homeostasis genes [divalent metal transporter 1 (SLC11A2), transferrin (TF), transferrin receptors (TFR2 and TFRC), and ferroportin (SLC40A1)] on Cd accumulation.	Iron	39-43	transferrin receptor	Homo sapiens	153-157
21198378-2	2011	For this reason, a novel polymerase chain reaction multiplex SNaPshot reaction has been developed that targets 10 autosomal mutations in genes, or regions near to them, reported to be involved in iron metabolism: TMPRSS6, TF, and HFE.	Iron	196-200	homeostatic iron regulator	Homo sapiens	230-233
23444034-6	2013	Furthermore, a disruption of iron homeostasis in the mutant flies was evidenced by an apparent reduction in induction of intestinal ferritin with ferric iron accumulating in a subcellular pattern reminiscent of mitochondria.	Iron	29-33	Ferritin 1 heavy chain homologue	Drosophila melanogaster	132-140
21161302-8	2011	FRDA is characterised by a mutation of the frataxin gene, the protein of which serves as an iron chaperone in iron-sulphur cluster assembly.	Iron	92-96	frataxin	Homo sapiens	0-4
23444034-7	2013	These phenotypes were specific to intestinal cell types that regulate ferritin expression, but were notably absent in the iron cells where ferritin is constitutively expressed and apparently translated independently of iron regulatory protein 1A.	Iron	122-126	Ferritin 1 heavy chain homologue	Drosophila melanogaster	139-147
21161302-8	2011	FRDA is characterised by a mutation of the frataxin gene, the protein of which serves as an iron chaperone in iron-sulphur cluster assembly.	Iron	92-96	frataxin	Homo sapiens	43-51
21161302-8	2011	FRDA is characterised by a mutation of the frataxin gene, the protein of which serves as an iron chaperone in iron-sulphur cluster assembly.	Iron	110-114	frataxin	Homo sapiens	0-4
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	51-55	hemopexin	Homo sapiens	108-117
21161302-8	2011	FRDA is characterised by a mutation of the frataxin gene, the protein of which serves as an iron chaperone in iron-sulphur cluster assembly.	Iron	110-114	frataxin	Homo sapiens	43-51
21161302-9	2011	The lack of frataxin expression leads to defective iron-sulphur cluster biogenesis with decreased respiratory and aconitase activity.	Iron	51-55	frataxin	Homo sapiens	12-20
21326867-6	2011	Despite iron accumulation within mitochondria, we found increased expression of transferrin receptor, Tfrc, at both the transcript and protein level in SOD2 deficient cells, suggesting deregulation of iron delivery.	Iron	201-205	transferrin receptor	Mus musculus	80-100
21326867-6	2011	Despite iron accumulation within mitochondria, we found increased expression of transferrin receptor, Tfrc, at both the transcript and protein level in SOD2 deficient cells, suggesting deregulation of iron delivery.	Iron	201-205	transferrin receptor	Mus musculus	102-106
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	hemopexin	Homo sapiens	108-117
21326867-7	2011	Interestingly, there was decreased expression of ABCb7, the gene responsible for X-linked hereditary SA with ataxia, a component required for iron-sulfur cluster biogenesis.	Iron	142-146	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	49-54
23350672-3	2013	Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~twofold after heme-hemopexin endocytosis by iron from heme catabolism via the iron-regulatory element of hAPP mRNA.	Iron	133-137	hemopexin	Homo sapiens	108-117
23350672-8	2013	Hemopexin sequesters heme, thus preventing unregulated heme uptake that leads to toxicity; it safely delivers heme to neuronal cells; and it activates the induction of proteins including HO1 and hAPP that keep heme and iron at safe levels in neurons.	Iron	219-223	hemopexin	Homo sapiens	0-9
21166997-7	2011	Our data substantiate the hypothesis that AtFH, apart from its role in protecting bioavailable iron within mitochondria and the biogenesis of Fe-S groups, also plays a role in the biosynthesis of heme groups in plants.	Iron	95-99	frataxin-like protein	Arabidopsis thaliana	42-46
23391334-0	2013	Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of beta-galactosidase activity.	Iron	36-40	galactosidase beta 1	Homo sapiens	83-101
21166997-7	2011	Our data substantiate the hypothesis that AtFH, apart from its role in protecting bioavailable iron within mitochondria and the biogenesis of Fe-S groups, also plays a role in the biosynthesis of heme groups in plants.	Iron	142-146	frataxin-like protein	Arabidopsis thaliana	42-46
23391334-1	2013	Targeting the increased Fe(3+) content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for (1)H-magnetic resonance imaging (MRI) detection of beta-galactosidase (beta-gal) activity.	Iron	106-110	galactosidase beta 1	Homo sapiens	184-202
21178077-11	2011	Iron intake from the study cereals was (mean +- SD) 1.21 +- 0.31 mg kg(-1) d(-1) from Cereal L and 1.07 +- 0.40 mg kg(-1) d(-1) from Cereal M. Eleven infants had low birth iron endowment (plasma ferritin &lt; 55 mug/L at 2 mo) and 54% of these infants had ID with or without anemia by 4 mo.	Iron	0-4	linker for activation of T cells family member 2	Homo sapiens	216-222
23391334-1	2013	Targeting the increased Fe(3+) content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for (1)H-magnetic resonance imaging (MRI) detection of beta-galactosidase (beta-gal) activity.	Iron	106-110	galactosidase beta 1	Homo sapiens	184-192
23353815-1	2013	Upregulation of Zip14 contributes to hepatic zinc (Zn) and non-transferrin-bound iron (Fe) uptake during infection and inflammation.	Iron	81-85	solute carrier family 39 (zinc transporter), member 14	Mus musculus	16-21
21219652-3	2011	Common mutations in the HFE gene, the gene responsible for the iron overload disorder hereditary hemochromatosis, may impact iron status.	Iron	63-67	homeostatic iron regulator	Homo sapiens	24-27
21725759-7	2011	Our results indicate that TPC reduction of iron-induced neuronal death may be through the p44/42 MAPK /p70 S6K signal transduction pathway.	Iron	43-47	mitogen activated protein kinase 3	Rattus norvegicus	90-93
21725759-7	2011	Our results indicate that TPC reduction of iron-induced neuronal death may be through the p44/42 MAPK /p70 S6K signal transduction pathway.	Iron	43-47	mitogen activated protein kinase 3	Rattus norvegicus	97-101
23353815-1	2013	Upregulation of Zip14 contributes to hepatic zinc (Zn) and non-transferrin-bound iron (Fe) uptake during infection and inflammation.	Iron	87-89	solute carrier family 39 (zinc transporter), member 14	Mus musculus	16-21
23517143-2	2013	In our previous study, the promoter of alcohol dehydrogenase, iron containing, 1 (ADHFE1) was most highly methylated in CRC compared to normal colorectal mucosa.	Iron	62-66	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	39-60
21183793-3	2011	Specifically, we demonstrated that phage clones displaying an iron-mimic peptide were able to target a protein complex of transferrin and transferrin receptor (TfR) through a non-canonical allosteric binding mechanism and that this functional protein complex mediated transport of the corresponding viral particles into the normal mouse brain.	Iron	62-66	transferrin receptor	Mus musculus	138-158
21183793-3	2011	Specifically, we demonstrated that phage clones displaying an iron-mimic peptide were able to target a protein complex of transferrin and transferrin receptor (TfR) through a non-canonical allosteric binding mechanism and that this functional protein complex mediated transport of the corresponding viral particles into the normal mouse brain.	Iron	62-66	transferrin receptor	Mus musculus	160-163
21183793-4	2011	We also showed that, in an orthotopic mouse model of human glioblastoma, a combination of TfR overexpression plus extended vascular permeability and ligand retention resulted in remarkable brain tumor targeting of chimeric adeno-associated virus/phage particles displaying the iron-mimic peptide and carrying a gene of interest.	Iron	277-281	transferrin receptor	Homo sapiens	90-93
23328867-1	2013	PURPOSE: Transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth.	Iron	114-118	transferrin receptor	Mus musculus	9-29
20638487-0	2011	Nuclear coded mitochondrial protein prohibitin is an iron regulated iron binding protein.	Iron	53-57	prohibitin 1	Homo sapiens	36-46
20638487-0	2011	Nuclear coded mitochondrial protein prohibitin is an iron regulated iron binding protein.	Iron	68-72	prohibitin 1	Homo sapiens	36-46
20638487-3	2011	Herein we report that nuclear coded mitochondrial protein prohibitin binds to iron and involved in intracellular iron homeostasis.	Iron	78-82	prohibitin 1	Homo sapiens	58-68
20638487-3	2011	Herein we report that nuclear coded mitochondrial protein prohibitin binds to iron and involved in intracellular iron homeostasis.	Iron	113-117	prohibitin 1	Homo sapiens	58-68
20638487-4	2011	Like other iron regulated proteins, prohibitin mRNA contains functional iron-response element and is regulated by intracellular iron levels.	Iron	11-15	prohibitin 1	Homo sapiens	36-46
20638487-4	2011	Like other iron regulated proteins, prohibitin mRNA contains functional iron-response element and is regulated by intracellular iron levels.	Iron	72-76	prohibitin 1	Homo sapiens	36-46
20638487-4	2011	Like other iron regulated proteins, prohibitin mRNA contains functional iron-response element and is regulated by intracellular iron levels.	Iron	72-76	prohibitin 1	Homo sapiens	36-46
23328867-1	2013	PURPOSE: Transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth.	Iron	114-118	transferrin receptor	Mus musculus	31-34
20638487-5	2011	Tyrosine residues involved in iron binding attribute of prohibitin are identified using site-directed mutagenesis.	Iron	30-34	prohibitin 1	Homo sapiens	56-66
20638487-6	2011	These data together suggest that prohibitin functions as an intracellular iron binding protein and plays a role in intracellular iron homeostasis.	Iron	74-78	prohibitin 1	Homo sapiens	33-43
20638487-6	2011	These data together suggest that prohibitin functions as an intracellular iron binding protein and plays a role in intracellular iron homeostasis.	Iron	129-133	prohibitin 1	Homo sapiens	33-43
23300182-2	2013	In particular, a strong association has been found between SF3B1 mutation and refractory anemia with ring sideroblasts, a condition characterized by ineffective erythropoiesis and parenchymal iron overload.	Iron	192-196	splicing factor 3b subunit 1	Homo sapiens	59-64
21346313-5	2011	Furthermore, we documented that both iron chelators significantly attenuated the elevated iron level and transferrin receptor expression, decreased oxygen free radicals and suppressed microglial and astrocytic activation in the spinal cords of the SOD1(G93A) mice.	Iron	37-41	transferrin receptor	Mus musculus	105-125
21886823-0	2011	Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.	Iron	0-4	T cell immunoglobulin and mucin domain containing 2	Mus musculus	53-58
21886823-5	2011	We tested whether ferritin binding to TIM-2 can serve as an iron delivery mechanism.	Iron	60-64	T cell immunoglobulin and mucin domain containing 2	Mus musculus	38-43
21886823-12	2011	HFt taken up by TIM-2 positive cells transited through the endosome and eventually entered a lysosomal compartment, distinguishing the HFt pathway from that of transferrin, the classical vehicle for cellular iron delivery.	Iron	208-212	T cell immunoglobulin and mucin domain containing 2	Mus musculus	16-21
21886823-13	2011	Iron delivered following binding of HFt to TIM-2 entered the cytosol and became metabolically available, resulting in increased levels of endogenous intracellular ferritin.	Iron	0-4	T cell immunoglobulin and mucin domain containing 2	Mus musculus	43-48
21886823-14	2011	We conclude that TIM-2 can function as an iron uptake pathway.	Iron	42-46	T cell immunoglobulin and mucin domain containing 2	Mus musculus	17-22
21799759-0	2011	The role of CyaY in iron sulfur cluster assembly on the E. coli IscU scaffold protein.	Iron	20-24	frataxin	Homo sapiens	12-16
21171997-10	2010	The ability of T. oceanica to tolerate iron limitation suggests that the transfer of petF from the chloroplast to the nuclear genome might have contributed to the ecological success of this species.	Iron	39-43	petF	Phaeodactylum tricornutum	85-89
20843714-0	2010	HFE gene mutations in patients with primary iron overload: is there a significant improvement in molecular diagnosis yield with HFE sequencing?	Iron	44-48	homeostatic iron regulator	Homo sapiens	0-3
20843714-1	2010	Rare HFE variants have been shown to be associated with hereditary hemochromatosis (HH), an iron overload disease.	Iron	92-96	homeostatic iron regulator	Homo sapiens	5-8
20843714-3	2010	The main aim was to screen for new HFE mutations in Brazilian individuals with primary iron overload and to investigate their relationship with HH.	Iron	87-91	homeostatic iron regulator	Homo sapiens	35-38
20889970-0	2010	Mitochondrial NADH kinase, Pos5p, is required for efficient iron-sulfur cluster biogenesis in Saccharomyces cerevisiae.	Iron	60-64	NADH kinase	Saccharomyces cerevisiae S288C	27-32
20889970-9	2010	Interestingly, Fe-S cluster biogenesis in wild-type mitochondria is further enhanced by overexpression of Pos5p.	Iron	15-19	NADH kinase	Saccharomyces cerevisiae S288C	106-111
20889970-10	2010	The effects of Pos5p on Fe-S cluster generation in mitochondria indicate that one or more steps in the biosynthetic process require NADPH.	Iron	24-28	NADH kinase	Saccharomyces cerevisiae S288C	15-20
21391831-1	2010	Soluble transferrin receptor (sTfR), one of the main regulators of cellular iron homeostasis, is the truncated form of the tissue receptor that is encoded by the human TfR gene (chromosome 3).	Iron	76-80	transferrin receptor	Homo sapiens	8-28
21391831-1	2010	Soluble transferrin receptor (sTfR), one of the main regulators of cellular iron homeostasis, is the truncated form of the tissue receptor that is encoded by the human TfR gene (chromosome 3).	Iron	76-80	transferrin receptor	Homo sapiens	31-34
21174348-1	2010	Hepcidin, a member of cysteine-rich antimicrobial peptides, plays an important role in both fish adaptive immunity and the regulation of iron metabolism.	Iron	137-141	hepcidin	Salmo salar	0-8
21235502-5	2010	Some dithiol glutaredoxins such as human Grx2 form dimers bridged by one iron-sulfur cluster, which acts as a sensor of oxidative stress, therefore regulating the activity of the glutaredoxin.	Iron	73-77	glutaredoxin	Homo sapiens	13-25
20574010-0	2010	Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress.	Iron	15-19	cathepsin D	Homo sapiens	68-79
21054916-7	2010	Mutations in hepcidin or its upstream regulators (HFE, TFR2, HFE2 and BMP6) lead to reduced or absent hepcidin expression and a concomitant increase in iron absorption.	Iron	152-156	homeostatic iron regulator	Homo sapiens	50-53
20726841-7	2010	The activity of aldehyde oxidase, a cytosolic Fe-S enzyme, was decreased in HYD3-knockdown lines, whereas Fe-S dependent activities in the chloroplast and mitochondria were unaffected.	Iron	46-50	uncharacterized protein	Chlamydomonas reinhardtii	76-80
20726841-8	2010	In addition, the HYD3-knockdown lines grew poorly on hypoxanthine, indicating impaired function of xanthine dehydrogenase, another cytosolic Fe-S enzyme.	Iron	141-145	uncharacterized protein	Chlamydomonas reinhardtii	17-21
20726841-10	2010	Together, our results clearly distinguish the cellular roles of HydA1 and HYD3, and indicate that HYD3, like its yeast and human homologues, has an evolutionary conserved role in the biogenesis or maintenance of cytosolic Fe-S proteins.	Iron	222-226	uncharacterized protein	Chlamydomonas reinhardtii	98-102
20634490-2	2010	BACKGROUND: Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.	Iron	59-63	homeostatic iron regulator	Homo sapiens	131-134
20814896-0	2010	A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis.	Iron	71-75	homeostatic iron regulator	Homo sapiens	88-91
20607309-1	2010	BACKGROUND: Lactoferrin (Lf) belongs to the transferrin family of non-heme iron-binding proteins and is found in milk and mucosal secretions.	Iron	75-79	lactotransferrin	Sus scrofa	12-23
20607309-1	2010	BACKGROUND: Lactoferrin (Lf) belongs to the transferrin family of non-heme iron-binding proteins and is found in milk and mucosal secretions.	Iron	75-79	lactotransferrin	Sus scrofa	25-27
20828813-6	2010	Mothers with depleted body iron stores had significantly greater placental expression of TfR than mothers with body iron stores greater than zero (p = 0.003).	Iron	27-31	transferrin receptor	Homo sapiens	89-92
20828813-7	2010	Neonatal iron stores were also inversely associated with the expression of placental TfR (p = 0.04, R(2) = 0.06).	Iron	9-13	transferrin receptor	Homo sapiens	85-88
20828813-9	2010	CONCLUSIONS: Expression of placental TfR is associated with both maternal and neonatal iron demands.	Iron	87-91	transferrin receptor	Homo sapiens	37-40
20828813-10	2010	Increased expression of placental TfR may be an important compensatory mechanism in response to iron deficiency in otherwise healthy pregnant women.	Iron	96-100	transferrin receptor	Homo sapiens	34-37
20981023-0	2010	Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly.	Iron	80-84	frataxin	Homo sapiens	40-48
20981023-2	2010	Independent reports have linked frataxin to iron-sulphur cluster assembly through interactions with the two central components of this machinery: desulphurase Nfs1/IscS and the scaffold protein Isu/IscU.	Iron	44-48	frataxin	Homo sapiens	32-40
20981023-2	2010	Independent reports have linked frataxin to iron-sulphur cluster assembly through interactions with the two central components of this machinery: desulphurase Nfs1/IscS and the scaffold protein Isu/IscU.	Iron	44-48	NFS1 cysteine desulfurase	Homo sapiens	159-163
20981023-2	2010	Independent reports have linked frataxin to iron-sulphur cluster assembly through interactions with the two central components of this machinery: desulphurase Nfs1/IscS and the scaffold protein Isu/IscU.	Iron	44-48	NFS1 cysteine desulfurase	Homo sapiens	164-168
20670216-5	2010	The decreased expression of CTR1 results in cellular copper deficiency and inhibition of Fet3 activity, which eventually impairs iron uptake.	Iron	129-133	ferroxidase FET3	Saccharomyces cerevisiae S288C	89-93
20682781-0	2010	ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin.	Iron	70-74	solute carrier family 39 member 14	Homo sapiens	0-23
20682781-0	2010	ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin.	Iron	70-74	solute carrier family 39 member 14	Homo sapiens	25-30
20682781-2	2010	Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediates the uptake of non-transferrin-bound iron, a form of iron that appears in the plasma during pathologic iron overload.	Iron	148-152	solute carrier family 39 member 14	Homo sapiens	97-102
20682781-2	2010	Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediates the uptake of non-transferrin-bound iron, a form of iron that appears in the plasma during pathologic iron overload.	Iron	164-168	solute carrier family 39 member 14	Homo sapiens	97-102
20682781-2	2010	Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediates the uptake of non-transferrin-bound iron, a form of iron that appears in the plasma during pathologic iron overload.	Iron	164-168	solute carrier family 39 member 14	Homo sapiens	97-102
20682781-3	2010	In this study we investigated the role of ZIP14 in the cellular assimilation of iron from transferrin, the circulating plasma protein that normally delivers iron to cells by receptor-mediated endocytosis.	Iron	80-84	solute carrier family 39 member 14	Homo sapiens	42-47
20682781-5	2010	We found that overexpression of ZIP14 in HEK 293T cells increased the assimilation of iron from transferrin without increasing levels of transferrin receptor 1 or the uptake of transferrin.	Iron	86-90	solute carrier family 39 member 14	Homo sapiens	32-37
21264406-0	2011	Prion protein expression level alters regional copper, iron and zinc content in the mouse brain.	Iron	55-59	prion protein	Mus musculus	0-13
21264406-3	2011	The host-encoded form of the prion protein (PrP(C)) binds multiple copper atoms via its N-terminal domain and can influence brain copper and iron levels.	Iron	141-145	prion protein	Mus musculus	29-42
21264406-3	2011	The host-encoded form of the prion protein (PrP(C)) binds multiple copper atoms via its N-terminal domain and can influence brain copper and iron levels.	Iron	141-145	prion protein	Mus musculus	44-50
21264406-6	2011	Brain sections from wild-type, prion gene knockout (Prnp(-/-)) and PrP(C) over-expressing mice revealed striking variation in the levels of iron, copper, and even zinc in specific brain regions as a function of PrP(C) expression.	Iron	140-144	prion protein	Mus musculus	67-73
21161377-1	2011	Hepcidin, a novel gene encoded, 25 residue, 2-3 KDa cysteine rich cationic peptide synthesized in liver cells play an important role in iron metabolism in addition to its antimicrobial activity.	Iron	136-140	hepcidin antimicrobial peptide	Bos taurus	0-8
21256461-3	2011	Interestingly, the ratio of 25-OH-D3 to 1-25-(OH)-D3 (a surrogate for parathyroid hormone [PTH]) is the strongest predictor of cardiac iron.	Iron	135-139	parathyroid hormone	Mus musculus	70-89
21256461-3	2011	Interestingly, the ratio of 25-OH-D3 to 1-25-(OH)-D3 (a surrogate for parathyroid hormone [PTH]) is the strongest predictor of cardiac iron.	Iron	135-139	parathyroid hormone	Mus musculus	91-94
21256461-4	2011	Increased PTH and 1-25-OH-D3 levels have been shown to up-regulate L-type voltage-gated calcium channels (LVGCC), the putative channel for cardiac iron uptake.	Iron	147-151	parathyroid hormone	Mus musculus	10-13
21298097-1	2011	BACKGROUND: Frataxin, the mitochondrial protein deficient in Friedreich ataxia, a rare autosomal recessive neurodegenerative disorder, is thought to be involved in multiple iron-dependent mitochondrial pathways.	Iron	173-177	frataxin	Homo sapiens	12-20
21298097-2	2011	In particular, frataxin plays an important role in the formation of iron-sulfur (Fe-S) clusters biogenesis.	Iron	81-85	frataxin	Homo sapiens	15-23
21298097-3	2011	METHODOLOGY/PRINCIPAL FINDINGS: We present data providing new insights into the interactions of mammalian frataxin with the Fe-S assembly complex by combining in vitro and in vivo approaches.	Iron	124-128	frataxin	Homo sapiens	106-114
21298097-4	2011	Through immunoprecipitation experiments, we show that the main endogenous interactors of a recombinant mature human frataxin are ISCU, NFS1 and ISD11, the components of the core Fe-S assembly complex.	Iron	178-182	frataxin	Homo sapiens	116-124
21298097-4	2011	Through immunoprecipitation experiments, we show that the main endogenous interactors of a recombinant mature human frataxin are ISCU, NFS1 and ISD11, the components of the core Fe-S assembly complex.	Iron	178-182	NFS1 cysteine desulfurase	Homo sapiens	135-139
20940420-2	2011	In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6).	Iron	14-18	transmembrane serine protease 6	Mus musculus	247-259
20940420-2	2011	In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6).	Iron	14-18	transmembrane serine protease 6	Mus musculus	272-279
20682781-8	2010	HepG2 cells in which endogenous ZIP14 was suppressed by siRNA assimilated 50% less iron from transferrin compared with controls.	Iron	83-87	solute carrier family 39 member 14	Homo sapiens	32-37
20682781-10	2010	We also found that ZIP14 can mediate the transport of iron at pH 6.5, the pH at which iron dissociates from transferrin within the endosome.	Iron	54-58	solute carrier family 39 member 14	Homo sapiens	19-24
20682781-10	2010	We also found that ZIP14 can mediate the transport of iron at pH 6.5, the pH at which iron dissociates from transferrin within the endosome.	Iron	86-90	solute carrier family 39 member 14	Homo sapiens	19-24
20682781-11	2010	These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism.	Iron	88-92	solute carrier family 39 member 14	Homo sapiens	37-42
20682781-11	2010	These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism.	Iron	88-92	solute carrier family 39 member 14	Homo sapiens	155-160
20682781-11	2010	These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism.	Iron	164-168	solute carrier family 39 member 14	Homo sapiens	37-42
20682781-11	2010	These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism.	Iron	164-168	solute carrier family 39 member 14	Homo sapiens	155-160
20815377-0	2010	Molecular details of the yeast frataxin-Isu1 interaction during mitochondrial Fe-S cluster assembly.	Iron	78-82	frataxin	Homo sapiens	31-39
23300182-7	2013	These observations suggest that patients with SF3B1 mutation have inappropriately low hepcidin levels, which may explain their propensity to parenchymal iron loading.	Iron	153-157	splicing factor 3b subunit 1	Homo sapiens	46-51
20815377-1	2010	Frataxin, a conserved nuclear-encoded mitochondrial protein, plays a direct role in iron-sulfur cluster biosynthesis within the ISC assembly pathway.	Iron	84-88	frataxin	Homo sapiens	0-8
20815377-2	2010	Humans with frataxin deficiency have Friedreich"s ataxia, a neurodegenerative disorder characterized by mitochondrial iron overload and disruption in Fe-S cluster synthesis.	Iron	118-122	frataxin	Homo sapiens	12-20
23303869-6	2013	This effect was shown to be iron-dependent, because iron repletion at postnatal d 21 normalized mTOR activity in the reversible DN TfR-1 model (62% reduction compared with unrepleted mice; P &lt; 0.05).	Iron	28-32	transferrin receptor	Mus musculus	131-136
20815377-2	2010	Humans with frataxin deficiency have Friedreich"s ataxia, a neurodegenerative disorder characterized by mitochondrial iron overload and disruption in Fe-S cluster synthesis.	Iron	150-154	frataxin	Homo sapiens	12-20
20815377-3	2010	Biochemical and genetic studies have shown frataxin interacts with the iron-sulfur cluster assembly scaffold protein (in yeast, there are two, Isu1 and Isu2), indicating frataxin plays a direct role in cluster assembly, possibly by serving as an iron chaperone in the assembly pathway.	Iron	71-75	frataxin	Homo sapiens	43-51
20815377-3	2010	Biochemical and genetic studies have shown frataxin interacts with the iron-sulfur cluster assembly scaffold protein (in yeast, there are two, Isu1 and Isu2), indicating frataxin plays a direct role in cluster assembly, possibly by serving as an iron chaperone in the assembly pathway.	Iron	71-75	frataxin	Homo sapiens	170-178
20815377-3	2010	Biochemical and genetic studies have shown frataxin interacts with the iron-sulfur cluster assembly scaffold protein (in yeast, there are two, Isu1 and Isu2), indicating frataxin plays a direct role in cluster assembly, possibly by serving as an iron chaperone in the assembly pathway.	Iron	246-250	frataxin	Homo sapiens	43-51
20815377-3	2010	Biochemical and genetic studies have shown frataxin interacts with the iron-sulfur cluster assembly scaffold protein (in yeast, there are two, Isu1 and Isu2), indicating frataxin plays a direct role in cluster assembly, possibly by serving as an iron chaperone in the assembly pathway.	Iron	246-250	frataxin	Homo sapiens	170-178
20558735-2	2010	Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical IREs controls iron-dependent translation of the ferritin subunits.	Iron	35-39	aconitase 1	Homo sapiens	61-65
23303869-6	2013	This effect was shown to be iron-dependent, because iron repletion at postnatal d 21 normalized mTOR activity in the reversible DN TfR-1 model (62% reduction compared with unrepleted mice; P &lt; 0.05).	Iron	52-56	transferrin receptor	Mus musculus	131-136
23307650-8	2013	Expression pattern analyses of the central oscillator genes in mutants defective in CIRCADIAN CLOCK ASSOCIATED1/LATE ELONGATED HYPOCOTYL or GIGANTEA demonstrated their requirement for Fe deficiency-induced long circadian period.	Iron	184-186	circadian clock associated 1	Arabidopsis thaliana	84-111
20622253-4	2010	Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs.	Iron	18-20	nei like DNA glycosylase 2	Homo sapiens	82-87
23512854-4	2013	Knocking out both YSL4 and YSL6 greatly reduces the plant"s ability to cope with excess iron.	Iron	88-92	YELLOW STRIPE like 4	Arabidopsis thaliana	18-22
20669901-3	2010	The active site of ACS is the A-cluster, which is an unusual nickel-iron-sulfur cluster.	Iron	68-72	acyl-CoA synthetase short chain family member 2	Homo sapiens	19-22
23512854-6	2013	Elemental analysis and histochemical staining indicate that iron is trapped in the chloroplasts of the ysl4 ysl6 double mutants, which also accumulate ferritins.	Iron	60-64	YELLOW STRIPE like 4	Arabidopsis thaliana	103-107
21197476-6	2011	The possibility of a HFE-C282Y-mediated interplay between the UPR and iron homeostasis influencing disease progression and the clinical heterogeneity among C282Y carriers is discussed.	Iron	70-74	homeostatic iron regulator	Homo sapiens	21-24
24431481-0	2010	RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for ATM, RAD9 and BRCA1.	Iron	32-36	RAD9 checkpoint clamp component A	Homo sapiens	83-87
23512854-8	2013	Furthermore, ubiquitous expression of YSL4 or YSL6 dramatically reduces plant tolerance to iron deficiency and decreases chloroplastic iron content.	Iron	91-95	YELLOW STRIPE like 4	Arabidopsis thaliana	38-42
24431481-5	2010	Our results show that cells heterozygous for both Atm and Rad9 or Atm and Brca1 have high survival rates and are more sensitive to transformation by high energy Iron ions when compared with wild-type controls or cells haploinsufficient for only one of these proteins.	Iron	161-165	RAD9 checkpoint clamp component A	Homo sapiens	58-62
23512854-9	2013	These data demonstrate a fundamental role for YSL4 and YSL6 in managing chloroplastic iron.	Iron	86-90	YELLOW STRIPE like 4	Arabidopsis thaliana	46-50
23512854-10	2013	YSL4 and YSL6 expression patterns support their physiological role in detoxifying iron during plastid dedifferentiation occurring in embryogenesis and senescence.	Iron	82-86	YELLOW STRIPE like 4	Arabidopsis thaliana	0-4
23223430-0	2013	An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia.	Iron	48-52	transmembrane serine protease 6	Mus musculus	30-37
20805566-6	2010	Interestingly, we found that a low level of duodenal divalent metal transporter 1 and ferroportin, two iron transporters located on the apical and basolateral membrane of duodenal absorptive enterocytes, respectively, correlates with abnormally high expression of hepcidin, despite the poor hepatic and overall iron status of these animals.	Iron	103-107	solute carrier family 11 member 2	Sus scrofa	53-81
19859668-3	2010	Iron uptake is facilitated by endocytosis of the Fe(2)Tf-TfR complex.	Iron	0-4	transferrin receptor	Homo sapiens	57-60
21205584-2	2011	Animal studies suggest that the dopamine D2 receptor (DRD2) mediates the effects of both lead and iron on cognition and behavior.	Iron	98-102	dopamine receptor D2	Homo sapiens	32-52
21205584-2	2011	Animal studies suggest that the dopamine D2 receptor (DRD2) mediates the effects of both lead and iron on cognition and behavior.	Iron	98-102	dopamine receptor D2	Homo sapiens	54-58
21402216-1	2011	The nickel- and iron-containing enzyme acetyl-CoA synthase (ACS) catalyzes de novo synthesis as well as overall cleavage of acetyl-CoA in acetogens, various other anaerobic bacteria, methanogens, and other archaea.	Iron	16-20	acyl-CoA synthetase short chain family member 2	Homo sapiens	39-58
21402216-1	2011	The nickel- and iron-containing enzyme acetyl-CoA synthase (ACS) catalyzes de novo synthesis as well as overall cleavage of acetyl-CoA in acetogens, various other anaerobic bacteria, methanogens, and other archaea.	Iron	16-20	acyl-CoA synthetase short chain family member 2	Homo sapiens	60-63
20569198-1	2010	In its aconitase-inactive form, IRP-1 (iron regulatory protein-1)/cytosolic aconitase binds to the IRE (iron-responsive element) of several mRNAs to effect post-transcriptional regulation.	Iron	39-43	aconitase 1	Homo sapiens	32-37
23223430-0	2013	An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia.	Iron	106-110	transmembrane serine protease 6	Mus musculus	30-37
21036394-2	2011	Cellular Fe uptake is mediated by the Transferrin Receptor 1 (TFRC), located in the trophoblast membranes.	Iron	9-11	transferrin receptor	Homo sapiens	38-60
21036394-2	2011	Cellular Fe uptake is mediated by the Transferrin Receptor 1 (TFRC), located in the trophoblast membranes.	Iron	9-11	transferrin receptor	Homo sapiens	62-66
23223430-4	2013	On this basis, we hypothesized that treatment of mouse models of HH (Hfe(-/-)) and -thalassemia intermedia (Hbb(th3/+)) with Tmprss6 siRNA formulated in lipid nanoparticles (LNPs) that are preferentially taken up by the liver would increase hepcidin expression and lessen the iron loading in both models.	Iron	276-280	transmembrane serine protease 6	Mus musculus	125-132
23223430-5	2013	In the present study, we demonstrate that LNP-Tmprss6 siRNA treatment of Hfe(-/-) and Hbb(th3/+) mice induces hepcidin and diminishes tissue and serum iron levels.	Iron	151-155	transmembrane serine protease 6	Mus musculus	46-53
20843199-1	2010	Genetic iron overload has long been confined to the picture of classical hemochromatosis related to the HFE C282Y mutation (type 1 hemochromatosis).	Iron	8-12	homeostatic iron regulator	Homo sapiens	104-107
23223430-7	2013	Our results indicate that pharmacologic manipulation of Tmprss6 with RNAi therapeutics isa practical approach to treating iron overload diseases associated with diminished hepcidin expression and may have efficacy in modifying disease-associated morbidities of -thalassemia intermedia.	Iron	122-126	transmembrane serine protease 6	Mus musculus	56-63
23196129-2	2013	Here, high CP expression was noted for the organic anion transporters, Oat1 (SLC22A6 or NKT) and Oat3 (SLC22A8) which are also the principal Oats in the renal proximal tubule, as well as SLC22A17, hypothesized to be involved in iron transport.	Iron	228-232	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	71-75
20583211-1	2010	UNLABELLED: Hemochromatosis gene (HFE)-associated hereditary hemochromatosis (HH) is a genetic predisposition to iron overload and subsequent signs and symptoms of disease that potentially affects approximately 80,000 persons in Australia and almost 1 million persons in the United States.	Iron	113-117	homeostatic iron regulator	Homo sapiens	34-37
21966538-11	2011	Taken together, these data extend our knowledge of the function of CD133 and underline the interest of further exploring the CD133-Tf-iron network.	Iron	134-138	prominin 1	Homo sapiens	125-130
21915296-10	2011	As expected, iron-starved Caco-2 cells internalized anti-TfR immunoliposomes better than controls.	Iron	13-17	transferrin receptor	Homo sapiens	57-60
23196129-2	2013	Here, high CP expression was noted for the organic anion transporters, Oat1 (SLC22A6 or NKT) and Oat3 (SLC22A8) which are also the principal Oats in the renal proximal tubule, as well as SLC22A17, hypothesized to be involved in iron transport.	Iron	228-232	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	77-84
23395174-5	2013	Expression of the iron transport genes DCytb, Dmt1, and ferroportin, as well as other HIF-2alpha targets, is enhanced in Irp1(-/-) duodenum.	Iron	18-22	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	46-50
21058400-2	2011	Ngb can reversibly bind small ligands such as O2 and CO to the heme iron by replacing the distal histidine which is bound to the iron as the endogenous ligand.	Iron	68-72	neuroglobin	Mus musculus	0-3
21058400-2	2011	Ngb can reversibly bind small ligands such as O2 and CO to the heme iron by replacing the distal histidine which is bound to the iron as the endogenous ligand.	Iron	129-133	neuroglobin	Mus musculus	0-3
20429018-7	2010	Disruptions in phosphate control also elicit an iron starvation response, as pho80 mutants were seen to upregulate iron transport genes.	Iron	48-52	Pho80p	Saccharomyces cerevisiae S288C	77-82
20429018-7	2010	Disruptions in phosphate control also elicit an iron starvation response, as pho80 mutants were seen to upregulate iron transport genes.	Iron	115-119	Pho80p	Saccharomyces cerevisiae S288C	77-82
23160040-0	2013	Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 transcription mediated by hypoxia inducible factor-1.	Iron	17-21	transferrin receptor	Homo sapiens	65-87
20583136-2	2010	However, the molecular mechanisms of APN-mediated COX-2 induction and its protection against iron-mediated injury in hepatocytes are still unclear.	Iron	93-97	cytochrome c oxidase II, mitochondrial	Mus musculus	50-55
20583136-8	2010	Herein, we demonstrate that APN-mediated COX-2 induction through a PPARalpha-dependent mechanism, and COX-2 exerted an anti-inflammatory effect of APN in hepatocytes subjected to iron challenge.	Iron	179-183	cytochrome c oxidase II, mitochondrial	Mus musculus	102-107
21801495-1	2011	Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-kappaB1(p50).	Iron	0-4	nuclear factor I/X	Mus musculus	64-68
23160040-9	2013	These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent transcriptional regulation of TfR1.	Iron	57-61	transferrin receptor	Homo sapiens	120-124
23085102-1	2013	We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner.	Iron	188-192	transferrin receptor	Homo sapiens	93-115
20863724-7	2010	We found that in human liver, not only HAMP, but also SMAD7 and Id1 mRNA significantly correlate with the extent of hepatic iron burden.	Iron	124-128	inhibitor of DNA binding 1, HLH protein	Homo sapiens	64-67
20627899-1	2010	In a previous work it was shown that ethylene participates in the up-regulation of several Fe acquisition genes of Arabidopsis, such as AtFIT, AtFRO2, and AtIRT1.	Iron	91-93	ferric reduction oxidase 2	Arabidopsis thaliana	143-149
20627899-6	2010	Further studies were performed to analyse whether Fe deficiency up-regulates the expression of genes involved in ethylene biosynthesis [S-adenosylmethionine synthetase, 1-aminocyclopropane-1-carboxylate (ACC) synthase, and ACC oxidase genes] and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3).	Iron	50-52	Protein kinase superfamily protein	Arabidopsis thaliana	266-272
20627899-6	2010	Further studies were performed to analyse whether Fe deficiency up-regulates the expression of genes involved in ethylene biosynthesis [S-adenosylmethionine synthetase, 1-aminocyclopropane-1-carboxylate (ACC) synthase, and ACC oxidase genes] and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3).	Iron	50-52	NRAMP metal ion transporter family protein	Arabidopsis thaliana	274-280
20627899-6	2010	Further studies were performed to analyse whether Fe deficiency up-regulates the expression of genes involved in ethylene biosynthesis [S-adenosylmethionine synthetase, 1-aminocyclopropane-1-carboxylate (ACC) synthase, and ACC oxidase genes] and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3).	Iron	50-52	Ethylene insensitive 3 family protein	Arabidopsis thaliana	282-288
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	S-adenosylmethionine synthetase 2	Arabidopsis thaliana	113-119
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	Protein kinase superfamily protein	Arabidopsis thaliana	189-195
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	NRAMP metal ion transporter family protein	Arabidopsis thaliana	197-203
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	Ethylene insensitive 3 family protein	Arabidopsis thaliana	205-211
20889968-10	2010	These functionally distinct FXN isoforms seem capable to ensure incremental rates of Fe-S cluster synthesis from different mitochondrial iron pools.	Iron	137-141	frataxin	Homo sapiens	28-31
23085102-1	2013	We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner.	Iron	188-192	transferrin receptor	Homo sapiens	117-121
20214491-3	2010	IRP1 and IRP2 are similar (but not identical) proteins with partially overlapping and complementary functions, and control cell iron metabolism by binding to IREs (i.e., conserved RNA stem-loops located in the untranslated regions of a dozen mRNAs directly or indirectly related to iron metabolism).	Iron	128-132	aconitase 1	Homo sapiens	0-4
23178912-5	2013	mRNA expression for transferrin receptor 1 (TfR1) and divalent metal transporter 1 was increased in G93A-SOD1 cells, which was in accordance with higher iron uptake.	Iron	153-157	transferrin receptor	Homo sapiens	20-42
20214491-3	2010	IRP1 and IRP2 are similar (but not identical) proteins with partially overlapping and complementary functions, and control cell iron metabolism by binding to IREs (i.e., conserved RNA stem-loops located in the untranslated regions of a dozen mRNAs directly or indirectly related to iron metabolism).	Iron	282-286	aconitase 1	Homo sapiens	0-4
20214491-5	2010	This review focuses on recent findings concerning the IRP-mediated regulation of iron homeostasis, its alterations in disease, and new research directions to be explored in the near future.	Iron	81-85	Wnt family member 2	Homo sapiens	54-57
20411304-9	2010	The data suggested that the induced elevation of NO level by exercise lead to the up-regulation of both TfR1 and DMT1 (IRE), which in turn increasing the iron absorption in skeletal muscle.	Iron	154-158	transferrin receptor	Rattus norvegicus	104-108
23178912-5	2013	mRNA expression for transferrin receptor 1 (TfR1) and divalent metal transporter 1 was increased in G93A-SOD1 cells, which was in accordance with higher iron uptake.	Iron	153-157	transferrin receptor	Homo sapiens	44-48
23265191-0	2013	Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly.	Iron	50-54	frataxin	Homo sapiens	10-18
20662012-11	2010	The data indicate that in Fet3p the N-linked glycan has little effect on the enzyme"s molecular activity but is critical to its cellular activity by maximizing the protein"s exit from the ER and assembly into a functional iron uptake complex.	Iron	222-226	ferroxidase FET3	Saccharomyces cerevisiae S288C	26-31
21070897-8	2010	These results suggest that aberrant FLVCR1 causes a selective degeneration of a subpopulation of neurons in the retina and the posterior columns of the spinal cord via dysregulation of heme or iron homeostasis.	Iron	193-197	feline leukemia virus subgroup C cellular receptor 1	Mus musculus	36-42
23265191-4	2013	Here, by comparing the biochemical and spectroscopic properties of quaternary (ISCU/NFS1/ISD11/FXN) and ternary (ISCU/NFS1/ISD11) complexes, we show that FXN stabilizes the quaternary complex and controls iron entry to the complex through activation of cysteine desulfurization.	Iron	205-209	NFS1 cysteine desulfurase	Homo sapiens	84-88
23265191-4	2013	Here, by comparing the biochemical and spectroscopic properties of quaternary (ISCU/NFS1/ISD11/FXN) and ternary (ISCU/NFS1/ISD11) complexes, we show that FXN stabilizes the quaternary complex and controls iron entry to the complex through activation of cysteine desulfurization.	Iron	205-209	NFS1 cysteine desulfurase	Homo sapiens	118-122
20826822-4	2010	Despite its classical CPYC active site, Grx1 forms dimeric iron-sulfur complexes with GSH, glutathionylspermidine, or trypanothione as non-protein ligands.	Iron	59-63	glutaredoxin	Homo sapiens	40-44
23265191-4	2013	Here, by comparing the biochemical and spectroscopic properties of quaternary (ISCU/NFS1/ISD11/FXN) and ternary (ISCU/NFS1/ISD11) complexes, we show that FXN stabilizes the quaternary complex and controls iron entry to the complex through activation of cysteine desulfurization.	Iron	205-209	frataxin	Homo sapiens	154-157
20698686-1	2010	Fet3p from Saccharomyces cerevisiae is a multicopper oxidase (MCO) which oxidizes Fe(2+) to Fe(3+).	Iron	82-84	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
23265191-6	2013	In the absence of FXN, although the ternary complex can assemble an Fe-S cluster, the cluster is inefficiently transferred to ACO2.	Iron	68-72	frataxin	Homo sapiens	18-21
23135277-6	2013	However, unlike wild type mice that manifest decreased hematocrit and hemoglobin levels when fed a low-iron diet, Fbxl5 heterozygotes maintain normal hematologic values due to increased iron absorption.	Iron	186-190	F-box and leucine-rich repeat protein 5	Mus musculus	114-119
20608701-5	2010	EDA-SAMMS and AC-CH(2)-EDA demonstrated rapid Cu(2+) sorption kinetics (minutes) and good sorption capacities (26 and 17 mg Cu/g sorbent, respectively) in seawater, whereas Phen-FMC had excellent selectivity for Cu(2+) over other metal ions (e.g., Ca(2+), Fe(2+), Ni(2+), and Zn(2+)) and was able to achieve Cu below the EPA recommended levels for river and sea waters.	Iron	256-258	ectodysplasin A	Homo sapiens	0-3
23135277-0	2013	F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.	Iron	101-105	F-box and leucine-rich repeat protein 5	Mus musculus	41-46
21031573-0	2010	Three faces of the same gene: FA2H links neurodegeneration with brain iron accumulation, leukodystrophies, and hereditary spastic paraplegias.	Iron	70-74	fatty acid 2-hydroxylase	Homo sapiens	30-34
23135277-2	2013	The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and facilitates IRP2 degradation in iron replete cells.	Iron	119-123	F-box and leucine-rich repeat protein 5	Mus musculus	72-77
20738301-1	2010	Transmembrane Protease, Serine 6 (TMPRSS6) has an important role in iron homeostasis and its mutations, performed in TMPRSS6-deficient mice, have been recently associated with iron-refractory iron deficiency anaemia (IRIDA).	Iron	68-72	transmembrane serine protease 6	Mus musculus	0-32
20738301-1	2010	Transmembrane Protease, Serine 6 (TMPRSS6) has an important role in iron homeostasis and its mutations, performed in TMPRSS6-deficient mice, have been recently associated with iron-refractory iron deficiency anaemia (IRIDA).	Iron	68-72	transmembrane serine protease 6	Mus musculus	34-41
20738301-1	2010	Transmembrane Protease, Serine 6 (TMPRSS6) has an important role in iron homeostasis and its mutations, performed in TMPRSS6-deficient mice, have been recently associated with iron-refractory iron deficiency anaemia (IRIDA).	Iron	68-72	transmembrane serine protease 6	Mus musculus	117-124
20608730-4	2010	Fe(2+) is an essential factor in ESP activity, although several recent studies have highlighted discrepancies in the understanding of the ESP-iron interaction.	Iron	142-146	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	138-141
20608730-9	2010	The results also indicated that reduction of ferric to ferrous iron drives variations in ESP activity during early plant development.	Iron	55-67	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	89-92
20608730-12	2010	It was concluded that manipulation of endogenous iron levels of ESP-containing plants could increase the conversion of glucosinolates to isothiocyanates and enhance potential health benefits.	Iron	49-53	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	64-67
23135277-2	2013	The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and facilitates IRP2 degradation in iron replete cells.	Iron	184-188	F-box and leucine-rich repeat protein 5	Mus musculus	72-77
20935638-2	2010	In vertebrates, serum transferrin is the major supplier of iron to tissues, but the function of additional transferrin-like proteins remains poorly understood.	Iron	59-63	Transferrin 1	Drosophila melanogaster	22-33
20828813-0	2010	Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents.	Iron	32-36	transferrin receptor	Homo sapiens	57-77
23135277-3	2013	Disruption of the ubiquitously expressed murine Fbxl5 gene results in a failure to sense increased cellular iron availability, accompanied by constitutive IRP2 accumulation and misexpression of IRP2 target genes.	Iron	108-112	F-box and leucine-rich repeat protein 5	Mus musculus	48-53
20828813-1	2010	OBJECTIVE: To elucidate the role of maternal and neonatal iron status on placental transferrin receptor (TfR) expression.	Iron	58-62	transferrin receptor	Homo sapiens	83-103
20400082-0	2010	Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?	Iron	80-84	homeostatic iron regulator	Homo sapiens	17-20
20400082-1	2010	BACKGROUND: The C282Y mutation of the hemochromatosis (HFE)-gene increases body iron status.	Iron	80-84	homeostatic iron regulator	Homo sapiens	55-58
20828813-1	2010	OBJECTIVE: To elucidate the role of maternal and neonatal iron status on placental transferrin receptor (TfR) expression.	Iron	58-62	transferrin receptor	Homo sapiens	105-108
23117987-11	2013	Both ferritin (Ft) and transferrin receptor (TfR) are routinely used as indicators of labile iron pool.	Iron	93-97	transferrin receptor	Rattus norvegicus	45-48
20828813-5	2010	RESULTS: Placental TfR expression was inversely associated with maternal iron status at mid-gestation (hemoglobin p = 0.046, R(2) = 0.1 and hematocrit p = 0.005, R(2) = 0.24) and at delivery (serum ferritin p = 0.02, R(2) = 0.08 and total body iron p = 0.02, R(2) = 0.07).	Iron	73-77	transferrin receptor	Homo sapiens	19-22
20828813-5	2010	RESULTS: Placental TfR expression was inversely associated with maternal iron status at mid-gestation (hemoglobin p = 0.046, R(2) = 0.1 and hematocrit p = 0.005, R(2) = 0.24) and at delivery (serum ferritin p = 0.02, R(2) = 0.08 and total body iron p = 0.02, R(2) = 0.07).	Iron	244-248	transferrin receptor	Homo sapiens	19-22
20336479-11	2010	This finding supports the hypothesis that DMT1 takes part in iron detoxification and homeostasis in the lung.	Iron	61-65	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	42-46
22960056-0	2013	Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.	Iron	66-70	SMAD family member 7	Mus musculus	10-15
20407804-8	2010	The ferric reductase activities of both NfnB and Fpr occurred with synthetic chelate iron compounds.	Iron	85-89	ferredoxin reductase	Homo sapiens	49-52
20407804-9	2010	Unlike NfnB, Fpr also showed the ferric reductase activity on an iron storage protein, ferritin, and various natural iron chelate compounds including siderophore.	Iron	65-69	ferredoxin reductase	Homo sapiens	13-16
20407804-9	2010	Unlike NfnB, Fpr also showed the ferric reductase activity on an iron storage protein, ferritin, and various natural iron chelate compounds including siderophore.	Iron	117-121	ferredoxin reductase	Homo sapiens	13-16
21284219-8	2010	The results showed that rHLF had comparable iron binding and releasing activity to that of native HLF.	Iron	44-48	HLF transcription factor, PAR bZIP family member	Rattus norvegicus	24-28
21284219-8	2010	The results showed that rHLF had comparable iron binding and releasing activity to that of native HLF.	Iron	44-48	HLF transcription factor, PAR bZIP family member	Rattus norvegicus	25-28
20709802-2	2010	Herein, we show that the deleterious effects of iron dextran on liver function and iron deposition were significantly reversed by adiponectin gene therapy, which was accompanied by AMP-activated protein kinase (AMPK) phosphorylation and heme oxygenase (HO)-1 induction.	Iron	48-52	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	181-209
20709802-2	2010	Herein, we show that the deleterious effects of iron dextran on liver function and iron deposition were significantly reversed by adiponectin gene therapy, which was accompanied by AMP-activated protein kinase (AMPK) phosphorylation and heme oxygenase (HO)-1 induction.	Iron	48-52	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	211-215
22960056-1	2013	The inhibitory Smad7 acts as a critical suppressor of hepcidin, the major regulator of systemic iron homeostasis.	Iron	96-100	SMAD family member 7	Mus musculus	15-20
22960056-3	2013	Using mouse models for hereditary hemochromatosis (Hfe-, TfR2-, Hfe/TfR2-, Hjv- and hepcidin1-deficient mice) we show that hepcidin, Smad6 and Smad7 mRNA expression is coordinated in such a way that it correlates with the activity of the Bmp/Smad signaling pathway rather than with liver iron levels.	Iron	288-292	SMAD family member 7	Mus musculus	143-148
19957051-7	2010	Corticosterone-induced elevation of IRP1 expression can cause increase of TfR1 and decrease of ferritin expression, which further leads to iron accumulation in hippocampal neurons and subsequently increases the oxidative damage of the neurons; it is indicated that corticosterone might be an important reason for iron deposition-caused neurodegenerative diseases.	Iron	139-143	aconitase 1	Homo sapiens	36-40
20631077-1	2010	The abundance of cell surface levels of transferrin receptor 1 (TfR1), which regulates the uptake of iron-bound transferring, correlates with the rate of cell proliferation.	Iron	101-105	transferrin receptor	Mus musculus	40-62
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	45-49	SMAD family member 7	Mus musculus	168-173
20631077-1	2010	The abundance of cell surface levels of transferrin receptor 1 (TfR1), which regulates the uptake of iron-bound transferring, correlates with the rate of cell proliferation.	Iron	101-105	transferrin receptor	Mus musculus	64-68
19957051-7	2010	Corticosterone-induced elevation of IRP1 expression can cause increase of TfR1 and decrease of ferritin expression, which further leads to iron accumulation in hippocampal neurons and subsequently increases the oxidative damage of the neurons; it is indicated that corticosterone might be an important reason for iron deposition-caused neurodegenerative diseases.	Iron	313-317	aconitase 1	Homo sapiens	36-40
20628369-0	2010	Identification of iron-loaded ferritin as an essential mitogen for cell proliferation and postembryonic development in Drosophila.	Iron	18-22	Ferritin 1 heavy chain homologue	Drosophila melanogaster	30-38
20628369-3	2010	Here I report the biochemical purification of iron-loaded ferritin as an active ingredient of fly extract that is required for promoting the growth of clone 8 imaginal disc cells.	Iron	46-50	Ferritin 1 heavy chain homologue	Drosophila melanogaster	58-66
23856650-4	2013	METHODS AND RESULTS: A 4-week iron loading protocol was instituted for both TXAS gene-deleted (TXAS(-/-)) mice and wild-type (WT) mice, with less severe cardiac fibrosis and preserved normal left ventricular contraction in the TXAS(-/-) mice.	Iron	30-34	thromboxane A synthase 1, platelet	Mus musculus	76-80
20628369-4	2010	Consistent with an essential role for iron-loaded ferritin in cultured cells, overexpression of ferritin or addition of iron in a nutrient-poor diet increases animal viability and body weight, promotes cell proliferation, and shortens the duration of postembryonic development.	Iron	38-42	Ferritin 1 heavy chain homologue	Drosophila melanogaster	50-58
20628369-4	2010	Consistent with an essential role for iron-loaded ferritin in cultured cells, overexpression of ferritin or addition of iron in a nutrient-poor diet increases animal viability and body weight, promotes cell proliferation, and shortens the duration of postembryonic development.	Iron	38-42	Ferritin 1 heavy chain homologue	Drosophila melanogaster	96-104
20628369-7	2010	I conclude that iron-loaded ferritin acts as an essential mitogen for cell proliferation and postembryonic development in Drosophila by maintaining iron homeostasis and antagonizing starvation response.	Iron	16-20	Ferritin 1 heavy chain homologue	Drosophila melanogaster	28-36
20628369-7	2010	I conclude that iron-loaded ferritin acts as an essential mitogen for cell proliferation and postembryonic development in Drosophila by maintaining iron homeostasis and antagonizing starvation response.	Iron	148-152	Ferritin 1 heavy chain homologue	Drosophila melanogaster	28-36
20219987-3	2010	FRDA is believed to arise from reduced synthesis of the mitochondrial iron chaperone frataxin due to impaired gene transcription, which leads to mitochondrial iron accumulation, dysfunction of mitochondrial Fe-S containing enzymes, and increased Fenton-mediated free radical production.	Iron	70-74	frataxin	Homo sapiens	0-4
20219987-3	2010	FRDA is believed to arise from reduced synthesis of the mitochondrial iron chaperone frataxin due to impaired gene transcription, which leads to mitochondrial iron accumulation, dysfunction of mitochondrial Fe-S containing enzymes, and increased Fenton-mediated free radical production.	Iron	70-74	frataxin	Homo sapiens	85-93
20219987-3	2010	FRDA is believed to arise from reduced synthesis of the mitochondrial iron chaperone frataxin due to impaired gene transcription, which leads to mitochondrial iron accumulation, dysfunction of mitochondrial Fe-S containing enzymes, and increased Fenton-mediated free radical production.	Iron	159-163	frataxin	Homo sapiens	0-4
20219987-3	2010	FRDA is believed to arise from reduced synthesis of the mitochondrial iron chaperone frataxin due to impaired gene transcription, which leads to mitochondrial iron accumulation, dysfunction of mitochondrial Fe-S containing enzymes, and increased Fenton-mediated free radical production.	Iron	159-163	frataxin	Homo sapiens	85-93
20219987-3	2010	FRDA is believed to arise from reduced synthesis of the mitochondrial iron chaperone frataxin due to impaired gene transcription, which leads to mitochondrial iron accumulation, dysfunction of mitochondrial Fe-S containing enzymes, and increased Fenton-mediated free radical production.	Iron	207-211	frataxin	Homo sapiens	0-4
20219987-3	2010	FRDA is believed to arise from reduced synthesis of the mitochondrial iron chaperone frataxin due to impaired gene transcription, which leads to mitochondrial iron accumulation, dysfunction of mitochondrial Fe-S containing enzymes, and increased Fenton-mediated free radical production.	Iron	207-211	frataxin	Homo sapiens	85-93
20628405-3	2010	In this crossover study, on three separate occasions, 10 patients who were homozygous for the C282Y mutation in the HFE gene (and fully treated) consumed a vegetarian meal containing 13.9 mg iron with: 200 ml water; 200 ml water and 140 mg silybin (Legalon Forte); or 200 ml tea.	Iron	191-195	homeostatic iron regulator	Homo sapiens	116-119
23856650-6	2013	TXAS supplement to the iron-injured TXAS(-/-) mice re-aggravated cardiac inflammation.	Iron	23-27	thromboxane A synthase 1, platelet	Mus musculus	0-4
23856650-6	2013	TXAS supplement to the iron-injured TXAS(-/-) mice re-aggravated cardiac inflammation.	Iron	23-27	thromboxane A synthase 1, platelet	Mus musculus	36-40
20675164-2	2010	We studied the role of HFE in macrophage iron metabolism.	Iron	41-45	homeostatic iron regulator	Homo sapiens	23-26
20675571-6	2010	Moreover, ILR3 interacts with a third protein, BRUTUS (BTS), a putative E3 ligase protein, with metal ion binding and DNA binding domains, which negatively regulates the response to iron deficiency.	Iron	182-186	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	10-14
20675164-8	2010	These results suggest that the non-functional C282Y form of HFE may alter the balance between cytosolic calcein-chelatable iron and sequestered iron, thereby disrupting the iron uptake and release equilibrium in cells involved in iron storage.	Iron	123-127	homeostatic iron regulator	Homo sapiens	60-63
23856650-8	2013	Finally, intraperitoneal injection of the TNF-alpha antibody, infliximab, into iron-injured mice decreased TXAS expression and attenuated cardiac fibrosis.	Iron	79-83	thromboxane A synthase 1, platelet	Mus musculus	107-111
20675164-8	2010	These results suggest that the non-functional C282Y form of HFE may alter the balance between cytosolic calcein-chelatable iron and sequestered iron, thereby disrupting the iron uptake and release equilibrium in cells involved in iron storage.	Iron	144-148	homeostatic iron regulator	Homo sapiens	60-63
20675164-8	2010	These results suggest that the non-functional C282Y form of HFE may alter the balance between cytosolic calcein-chelatable iron and sequestered iron, thereby disrupting the iron uptake and release equilibrium in cells involved in iron storage.	Iron	144-148	homeostatic iron regulator	Homo sapiens	60-63
23116397-8	2013	This review will focus on three major redox metabolic pathways which may provide promising strategies to fight against pathogens: the non-mevalonate pathway for isoprenoids biosynthesis, the iron metabolism and the iron-sulfur proteins.The common attractive link of all these processes is the plant-type ferredoxin-NADP+ reductase, an enzyme that participates in numerous electron transfer reactions and has no homologous enzyme in humans.	Iron	191-195	ferredoxin reductase	Homo sapiens	304-330
20675164-8	2010	These results suggest that the non-functional C282Y form of HFE may alter the balance between cytosolic calcein-chelatable iron and sequestered iron, thereby disrupting the iron uptake and release equilibrium in cells involved in iron storage.	Iron	144-148	homeostatic iron regulator	Homo sapiens	60-63
20805500-1	2010	The nonclassical MHC class I-related (MHC-I) molecule HFE controls cellular iron homeostasis by a mechanism that has not been fully elucidated.	Iron	76-80	homeostatic iron regulator	Homo sapiens	54-57
20805500-6	2010	The results show regulated expression of HFE by ubiquitination, consistent with a role in cellular iron homeostasis, a molecular mechanism targeted by KSHV to achieve a positive iron balance.	Iron	99-103	homeostatic iron regulator	Homo sapiens	41-44
20805500-6	2010	The results show regulated expression of HFE by ubiquitination, consistent with a role in cellular iron homeostasis, a molecular mechanism targeted by KSHV to achieve a positive iron balance.	Iron	178-182	homeostatic iron regulator	Homo sapiens	41-44
20426397-1	2010	The redox properties of Fe and Zn complexes coordinated by an alpha-diimine based N(4)-macrocyclic ligand (TIM) have been examined using spectroscopic methods and density functional theory (DFT) computational analysis.	Iron	24-26	Rho guanine nucleotide exchange factor 5	Homo sapiens	107-110
20124431-7	2010	Finally, we show that oncostatin M administration in vivo increases hepcidin expression and leads to significantly decreased serum iron levels.	Iron	131-135	oncostatin M	Homo sapiens	22-34
23116397-8	2013	This review will focus on three major redox metabolic pathways which may provide promising strategies to fight against pathogens: the non-mevalonate pathway for isoprenoids biosynthesis, the iron metabolism and the iron-sulfur proteins.The common attractive link of all these processes is the plant-type ferredoxin-NADP+ reductase, an enzyme that participates in numerous electron transfer reactions and has no homologous enzyme in humans.	Iron	215-219	ferredoxin reductase	Homo sapiens	304-330
23581600-2	2013	The iron gateway to cells is transferrin receptor (TfR).	Iron	4-8	transferrin receptor	Homo sapiens	29-49
20402790-1	2010	Haemophilus parasuis, the etiological agent of Glasser"s disease in pigs, possesses iron acquisition pathways mediated by a surface receptor that specifically bind porcine transferrin.	Iron	84-88	transferrin	Sus scrofa	172-183
20610401-9	2010	Together, these data argue that hemopexin has a role in assuring systemic iron balance during homeostasis in addition to its established role as a scavenger during internal bleeding or hemolysis.	Iron	74-78	hemopexin	Homo sapiens	32-41
23581600-2	2013	The iron gateway to cells is transferrin receptor (TfR).	Iron	4-8	transferrin receptor	Homo sapiens	51-54
20716799-2	2010	Transferrin receptor (CD71) mediates the uptake of transferrin-iron complexes and is highly expressed on the surface of cells of the erythroid lineage.	Iron	63-67	transferrin receptor	Homo sapiens	0-20
23936609-3	2013	Frataxin is a mitochondrial protein that functions primarily in iron-sulfur cluster synthesis.	Iron	64-68	frataxin	Homo sapiens	0-8
20716799-2	2010	Transferrin receptor (CD71) mediates the uptake of transferrin-iron complexes and is highly expressed on the surface of cells of the erythroid lineage.	Iron	63-67	transferrin receptor	Homo sapiens	22-26
20132520-4	2010	Comparison of the sequences of putative plastid transporters from Arabidopsis thaliana with those involved in cyanobacterial Fe transport identified two orthologs of the FutC protein, AtNAP11 and AtNAP14.	Iron	125-127	nucleosome assembly protein1;4	Arabidopsis thaliana	196-203
20397659-2	2010	Critical to the delivery of iron to cells is the binding of hTF to the TFR and the efficient release of iron orchestrated by the interaction.	Iron	28-32	transferrin receptor	Homo sapiens	71-74
20397659-6	2010	In the current study, the kinetics of iron release from alanine mutants of each of these four residues (placed into both diferric and monoferric N-lobe backgrounds) have been determined +/- the TFR.	Iron	38-42	transferrin receptor	Homo sapiens	194-197
20397659-7	2010	The R143A mutation greatly retards the rate of iron release from the N-lobe in the absence of the TFR but has considerably less of an effect in its presence.	Iron	47-51	transferrin receptor	Homo sapiens	98-101
20604729-0	2010	Transferrin receptor expression on reticulocytes as a marker of iron status in dialyzed patients.	Iron	64-68	transferrin receptor	Homo sapiens	0-20
20604729-3	2010	This study was conducted to investigate whether transferrin receptor (TfR) expression on reticulocytes can reflect iron status in patients with chronic renal failure (CRF).	Iron	115-119	transferrin receptor	Homo sapiens	48-68
23936609-6	2013	In cells, frataxin deficiency leads to pleiotropic phenotypes, including deregulation of iron homeostasis and increased oxidative stress.	Iron	89-93	frataxin	Homo sapiens	10-18
20604729-3	2010	This study was conducted to investigate whether transferrin receptor (TfR) expression on reticulocytes can reflect iron status in patients with chronic renal failure (CRF).	Iron	115-119	transferrin receptor	Homo sapiens	70-73
20604729-9	2010	CONCLUSIONS: Reticulocyte TfR expression reflected the changes in the Hb level and the iron availability at the cellular level, and therefore it might be useful in the assessment of iron status in patients with CRF.	Iron	87-91	transferrin receptor	Homo sapiens	26-29
23144187-3	2013	Transcriptome analysis of an Arabidopsis (Arabidopsis thaliana) mutant defective in RNA polymerase II C-terminal domain-phosphatase-like1 (CPL1) revealed significant up-regulation of Fe utilization-related genes (e.g. IRON-REGULATED TRANSPORTER1), suggesting the importance of RNA metabolism in Fe signaling.	Iron	183-185	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	102-137
20604729-9	2010	CONCLUSIONS: Reticulocyte TfR expression reflected the changes in the Hb level and the iron availability at the cellular level, and therefore it might be useful in the assessment of iron status in patients with CRF.	Iron	182-186	transferrin receptor	Homo sapiens	26-29
20420442-1	2010	The Monkstown zero-valent iron permeable reactive barrier (ZVI PRB), Europe"s oldest commercially-installed ZVI PRB, had been treating trichloroethene (TCE) contaminated groundwater for about 10 years on the Nortel Network site in Northern Ireland when cores from the reactive zone were collected in December, 2006.	Iron	26-30	RB transcriptional corepressor 1	Homo sapiens	63-66
20420442-1	2010	The Monkstown zero-valent iron permeable reactive barrier (ZVI PRB), Europe"s oldest commercially-installed ZVI PRB, had been treating trichloroethene (TCE) contaminated groundwater for about 10 years on the Nortel Network site in Northern Ireland when cores from the reactive zone were collected in December, 2006.	Iron	59-62	RB transcriptional corepressor 1	Homo sapiens	63-66
23144187-3	2013	Transcriptome analysis of an Arabidopsis (Arabidopsis thaliana) mutant defective in RNA polymerase II C-terminal domain-phosphatase-like1 (CPL1) revealed significant up-regulation of Fe utilization-related genes (e.g. IRON-REGULATED TRANSPORTER1), suggesting the importance of RNA metabolism in Fe signaling.	Iron	183-185	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	139-143
20420442-1	2010	The Monkstown zero-valent iron permeable reactive barrier (ZVI PRB), Europe"s oldest commercially-installed ZVI PRB, had been treating trichloroethene (TCE) contaminated groundwater for about 10 years on the Nortel Network site in Northern Ireland when cores from the reactive zone were collected in December, 2006.	Iron	59-62	RB transcriptional corepressor 1	Homo sapiens	112-115
20420442-1	2010	The Monkstown zero-valent iron permeable reactive barrier (ZVI PRB), Europe"s oldest commercially-installed ZVI PRB, had been treating trichloroethene (TCE) contaminated groundwater for about 10 years on the Nortel Network site in Northern Ireland when cores from the reactive zone were collected in December, 2006.	Iron	108-111	RB transcriptional corepressor 1	Homo sapiens	63-66
20824191-4	2010	Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function.	Iron	45-49	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-7
23723737-1	2013	Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life.	Iron	72-76	transferrin receptor	Homo sapiens	22-26
20547568-2	2010	Furthermore, the HTT gene has been functionally linked to iron (Fe) metabolism, and HD patients show alterations in brain and peripheral Fe homeostasis.	Iron	58-62	huntingtin	Homo sapiens	17-20
19556267-0	2010	Nitric oxide and frataxin: two players contributing to maintain cellular iron homeostasis.	Iron	73-77	frataxin	Homo sapiens	17-25
19556267-11	2010	Frataxin, a recently identified protein in plants, plays an important role in mitochondria biogenesis and in maintaining mitochondrial iron homeostasis.	Iron	135-139	frataxin	Homo sapiens	0-8
19556267-12	2010	Evidence regarding the interaction between frataxin, NO and iron from analysis of frataxin knock-down Arabidopsis thaliana mutants is reviewed and discussed.	Iron	60-64	frataxin	Homo sapiens	82-90
23723737-6	2013	We show that naturally occurring mutations at these positions block virus entry while simultaneously preserving iron-uptake functionalities, both in rodent and human TfR1.	Iron	112-116	transferrin receptor	Homo sapiens	166-170
23723739-7	2013	use a combination of phylogenetic, structural, and virological analysis to infer the history and significance of positive selection on the transferrin receptor TfR1, a housekeeping protein required for iron uptake and the cell surface receptor for at least three different types of virus.	Iron	202-206	transferrin receptor	Homo sapiens	160-164
20522547-5	2010	Frataxin interacts with Isu, iron, and the cysteine desulfurase Nfs1, which supplies sulfide, thus placing it at the center of mitochondrial FeS cluster biosynthesis.	Iron	29-33	frataxin	Homo sapiens	0-8
20404999-1	2010	The cysteine desulfurase IscS is a highly conserved master enzyme initiating sulfur transfer via persulfide to a range of acceptor proteins involved in Fe-S cluster assembly, tRNA modifications, and sulfur-containing cofactor biosynthesis.	Iron	152-154	NFS1 cysteine desulfurase	Homo sapiens	25-29
23964827-1	2013	BACKGROUND: Studies detected an association between visfatin and markers of iron metabolism in patients with insulin resistance.	Iron	76-80	nicotinamide phosphoribosyltransferase	Homo sapiens	52-60
20404999-2	2010	Several IscS-interacting partners including IscU, a scaffold for Fe-S cluster assembly; TusA, the first member of a sulfur relay leading to sulfur incorporation into the wobble uridine of several tRNAs; ThiI, involved in tRNA modification and thiamine biosynthesis; and rhodanese RhdA are sulfur acceptors.	Iron	65-67	NFS1 cysteine desulfurase	Homo sapiens	8-12
20404999-9	2010	Our data support the role of frataxin as an iron donor for IscU to form the Fe-S clusters.	Iron	44-48	frataxin	Homo sapiens	29-37
20404999-9	2010	Our data support the role of frataxin as an iron donor for IscU to form the Fe-S clusters.	Iron	76-80	frataxin	Homo sapiens	29-37
20405006-1	2010	Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression.	Iron	65-69	aconitase 1	Homo sapiens	26-30
20723262-6	2010	RESULTS: Human breast cancer MDA-MB-231 cells were transfected with transferrin receptor-1 (TfR1) shRNA to constitutively impair iron uptake.	Iron	129-133	transferrin receptor	Homo sapiens	68-90
20723262-6	2010	RESULTS: Human breast cancer MDA-MB-231 cells were transfected with transferrin receptor-1 (TfR1) shRNA to constitutively impair iron uptake.	Iron	129-133	transferrin receptor	Homo sapiens	92-96
20430476-4	2010	Functional complementation with AhIRT1 restored normal growth of the yeast mutant fet3fet4 (defective in both high- and low-affinity iron-uptake systems) under iron-deficiency conditions.	Iron	133-137	ferroxidase FET3	Saccharomyces cerevisiae S288C	82-90
23964827-10	2013	From the markers of iron metabolism, the hepcidin included, visfatin was related only to TSAT.	Iron	20-24	nicotinamide phosphoribosyltransferase	Homo sapiens	60-68
23151016-3	2012	A Co-/Fe-coordinating pyrolyzed polymer exhibited a high specific oxygen reduction activity with onset and half-wave potentials of 0.87 and 0.76 V vs RHE, respectively, in neutral media.	Iron	6-8	factor interacting with PAPOLA and CPSF1	Homo sapiens	150-153
20558581-0	2010	Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload.	Iron	93-97	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	15-22
20558581-7	2010	Iron supplementation caused suppression of endogenous duodenal SLC11A2 expression, down-regulation of duodenal ferroportin, and overexpression of hepatic hepcidin, precluding excessive iron uptake both in the TGs and wild-type mice.	Iron	0-4	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	63-70
20107990-1	2010	Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption.	Iron	36-40	homeostatic iron regulator	Homo sapiens	17-20
20107990-1	2010	Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption.	Iron	113-117	homeostatic iron regulator	Homo sapiens	17-20
20107990-1	2010	Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption.	Iron	113-117	homeostatic iron regulator	Homo sapiens	17-20
20107990-10	2010	All the HFE genotypes except for the S65C heterozygote together with the alcohol, iron and calcium intake affect the indicators of iron status.	Iron	82-86	homeostatic iron regulator	Homo sapiens	8-11
20107990-10	2010	All the HFE genotypes except for the S65C heterozygote together with the alcohol, iron and calcium intake affect the indicators of iron status.	Iron	131-135	homeostatic iron regulator	Homo sapiens	8-11
20498629-7	2010	The unique means by which miR-210 regulates mitochondrial function reveals an miRNA-mediated link between microenvironmental stress, oxidative phosphorylation, ROS and iron homeostasis.	Iron	114-118	microRNA 210	Homo sapiens	26-33
20659343-2	2010	Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which is known to affect birth weight.	Iron	43-47	homeostatic iron regulator	Homo sapiens	38-41
20530676-1	2010	The major route of iron uptake by cells occurs through transferrin receptor (TfR)-mediated endocytosis of diferric-charged plasma transferrin (holo-Tf).	Iron	19-23	transferrin receptor	Homo sapiens	55-75
20530676-1	2010	The major route of iron uptake by cells occurs through transferrin receptor (TfR)-mediated endocytosis of diferric-charged plasma transferrin (holo-Tf).	Iron	19-23	transferrin receptor	Homo sapiens	77-80
20530676-8	2010	Together, our findings define a new class of fully human anti-TfR antibodies suitable for immunotherapy against tumors whose proliferation relies on high levels of TfR and iron uptake, such as acute lymphoid and myeloid leukemias.	Iron	172-176	transferrin receptor	Homo sapiens	62-65
20497464-2	2010	Transferrin receptor (TFRC) constitutes the major receptor by which most cells take up iron.	Iron	87-91	transferrin receptor	Homo sapiens	0-20
20497464-2	2010	Transferrin receptor (TFRC) constitutes the major receptor by which most cells take up iron.	Iron	87-91	transferrin receptor	Homo sapiens	22-26
20530571-5	2010	In the absence of Gef1, a multicopper oxidase involved in iron uptake, Fet3, fails to acquire copper ion cofactors.	Iron	58-62	ferroxidase FET3	Saccharomyces cerevisiae S288C	71-75
20576116-0	2010	Environmental transcriptome analysis reveals physiological differences between biofilm and planktonic modes of life of the iron oxidizing bacteria Leptospirillum spp.	Iron	3-7	histocompatibility minor 13	Homo sapiens	162-165
20576116-4	2010	In the Rio Tinto (Spain), brown filaments develop under the water stream where the Gram-negative iron-oxidizing bacteria Leptospirillum spp.	Iron	97-101	histocompatibility minor 13	Homo sapiens	136-139
20382770-11	2010	The expression of rmpA is regulated by the availability of iron and is negatively controlled by Fur.	Iron	59-63	regulator of mucoid phenotype	Klebsiella pneumoniae CG43	18-22
20397659-8	2010	Our data definitively show that Arg143 serves as a kinetically significant anion binding (KISAB) site that is, by definition, sensitive to salt concentration and critical to the conformational change necessary to induce iron release from the N-lobe of hTF (in the absence of the TFR).	Iron	220-224	transferrin receptor	Homo sapiens	279-282
20200349-0	2010	Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.	Iron	89-93	transmembrane serine protease 6	Mus musculus	41-48
20200349-3	2010	Both humans and mice with TMPRSS6 mutations show inappropriately elevated levels of the iron-regulatory hormone hepcidin, suggesting that TMPRSS6 acts to negatively regulate hepcidin expression.	Iron	88-92	transmembrane serine protease 6	Mus musculus	26-33
20200349-3	2010	Both humans and mice with TMPRSS6 mutations show inappropriately elevated levels of the iron-regulatory hormone hepcidin, suggesting that TMPRSS6 acts to negatively regulate hepcidin expression.	Iron	88-92	transmembrane serine protease 6	Mus musculus	138-145
20200349-5	2010	We show that livers from mice deficient for Tmprss6 have decreased iron stores and decreased Bmp6 mRNA, but markedly increased mRNA for Id1, a target gene of Bmp6 signaling.	Iron	67-71	transmembrane serine protease 6	Mus musculus	44-51
20200349-6	2010	In contrast, mice deficient for both Tmprss6 and hemojuvelin (Hjv), a BMP coreceptor that augments hepcidin expression in hepatocytes, showed markedly decreased hepatic levels of hepcidin and Id1 mRNA, markedly increased hepatic Bmp6 mRNA levels, and systemic iron overload similar to mice deficient for Hjv alone.	Iron	260-264	transmembrane serine protease 6	Mus musculus	37-44
20200349-7	2010	These findings suggest that down-regulation of Bmp/Smad signaling by Tmprss6 is required for regulation of hepcidin expression and maintenance of systemic iron homeostasis.	Iron	155-159	transmembrane serine protease 6	Mus musculus	69-76
20348389-5	2010	Chlamydomonas FOX1 is a homolog of the human ferroxidases but likely supports iron uptake in a manner similar to that of yeast, since Chlamydomonas reinhardtii expresses a ferric iron permease homolog, FTR1.	Iron	78-82	uncharacterized protein	Chlamydomonas reinhardtii	14-18
20348389-9	2010	We demonstrate that high-affinity iron uptake is dependent on FOX1 and the copper status of the cell.	Iron	34-38	uncharacterized protein	Chlamydomonas reinhardtii	62-66
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	72-76	aconitase 1	Homo sapiens	130-155
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	72-76	aconitase 1	Homo sapiens	157-161
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	130-134	aconitase 1	Homo sapiens	157-161
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	130-134	aconitase 1	Homo sapiens	157-161
20208481-10	2010	In conclusion, total H63D mutations were high (42%) in cirrhotics with alpha-1-antitrypsin deficiency and there was a significant association between HFE mutations and high levels of iron accumulation.	Iron	183-187	homeostatic iron regulator	Homo sapiens	150-153
20448661-3	2010	The VHL protein is a component of the oxygen and iron sensing pathway that regulates hypoxia-inducible factor (HIF) levels in the cell.	Iron	49-53	von Hippel-Lindau tumor suppressor	Homo sapiens	4-7
20593115-7	2010	The genetic variation implicated in iron overload and iron deficiency anaemia, involves mutations in several genes such as HFE, TFR2,HAMP, HJV, Tf and TMPRSS6.	Iron	36-40	homeostatic iron regulator	Homo sapiens	123-126
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	70-74	transferrin receptor	Homo sapiens	157-160
20188707-3	2010	Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA silencing construct leads to a significant decrease in Tf-mediated iron uptake.	Iron	293-297	transferrin receptor	Homo sapiens	157-160
20188707-4	2010	Our results thus indicate that MRCKalpha takes part in Tf-iron uptake, probably via regulation of Tf-TfR endocytosis/endosome trafficking that is dependent on the cellular cytoskeleton.	Iron	58-62	transferrin receptor	Homo sapiens	101-104
20429907-9	2010	More importantly, the iron content of ferritin determines its efficiency of uptake and transport by Caco-2 cells and mouse models, providing insight into the mechanism(s) of ferritin and PrPSc uptake by intestinal epithelial cells.	Iron	22-26	prion protein	Mus musculus	187-192
20404999-0	2010	Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.	Iron	21-25	NFS1 cysteine desulfurase	Homo sapiens	75-79
20060900-8	2010	To evaluate whether cellular iron status could influence Pin1, we treated the WT HFE cells with exogenous iron and found that Pin1 phosphorylation increased with increasing levels of iron.	Iron	106-110	homeostatic iron regulator	Homo sapiens	81-84
20060900-8	2010	To evaluate whether cellular iron status could influence Pin1, we treated the WT HFE cells with exogenous iron and found that Pin1 phosphorylation increased with increasing levels of iron.	Iron	106-110	homeostatic iron regulator	Homo sapiens	81-84
20108066-1	2010	Frataxin, a nuclear encoded protein targeted to the mitochondrial matrix, has recently been implicated as an iron chaperone that delivers Fe(II) to the iron-sulfur assembly enzyme ISU.	Iron	109-113	frataxin	Homo sapiens	0-8
20108066-1	2010	Frataxin, a nuclear encoded protein targeted to the mitochondrial matrix, has recently been implicated as an iron chaperone that delivers Fe(II) to the iron-sulfur assembly enzyme ISU.	Iron	152-156	frataxin	Homo sapiens	0-8
20236681-2	2010	The Fe-Ag bimetallic nanoparticles with core-shell structure were successfully synthesized by reduction and deposition of Ag on nanoscale Fe surface, and were further characterized by BET, XRD, TEM, SEM, X-ray fluorescence and X-ray photo-electron spectroscopy.	Iron	4-6	delta/notch like EGF repeat containing	Homo sapiens	184-187
20303568-0	2010	Application of zerovalent iron (Fe(0)) to enhance degradation of HCHs and DDX in soil from a former organochlorine pesticides manufacturing plant.	Iron	26-30	aldo-keto reductase family 1 member C3	Homo sapiens	74-77
20303568-0	2010	Application of zerovalent iron (Fe(0)) to enhance degradation of HCHs and DDX in soil from a former organochlorine pesticides manufacturing plant.	Iron	32-37	aldo-keto reductase family 1 member C3	Homo sapiens	74-77
20303568-2	2010	Application of zerovalent iron (Fe(0)) was investigated to accelerate the degradation of HCHs (alpha-, beta-, gamma- and delta-hexachlorocyclohexane) and DDX (DDT, DDE and DDD) in the soil from a former organochlorine pesticide manufacturing plant.	Iron	26-30	aldo-keto reductase family 1 member C3	Homo sapiens	95-157
20303568-2	2010	Application of zerovalent iron (Fe(0)) was investigated to accelerate the degradation of HCHs (alpha-, beta-, gamma- and delta-hexachlorocyclohexane) and DDX (DDT, DDE and DDD) in the soil from a former organochlorine pesticide manufacturing plant.	Iron	32-37	aldo-keto reductase family 1 member C3	Homo sapiens	95-157
19952282-6	2010	While the analogous dinitrosyl-diglutathionyl iron complex formed in mammalian cells is a potent irreversible inhibitor of glutathione reductase (IC(50)=4 microM), the T(SH)(2) complex does not inactivate TR even at millimolar levels.	Iron	46-50	glutathione-disulfide reductase	Homo sapiens	123-144
20193033-7	2010	This study observes for the first time that an altered adhesion molecules profile occurs in patients with HH that is associated with specific HFE genetic component for iron overload, suggesting that differential expression of adhesion molecules may play a role in the pathogenesis of HH.	Iron	168-172	homeostatic iron regulator	Homo sapiens	142-145
20062004-1	2010	The iron-sulphur (Fe-S)-containing RNase L inhibitor (Rli1) is involved in ribosomal subunit maturation, transport of both ribosomal subunits to the cytoplasm, and translation initiation through interaction with the eukaryotic initiation factor 3 (eIF3) complex.	Iron	18-22	Fe-S cluster-binding ribosome biosynthesis protein	Saccharomyces cerevisiae S288C	54-58
20133674-9	2010	The demonstration that TfR1 can bind HFt as well as Tf raises the possibility that this dual receptor function may coordinate the processing and use of iron by these iron-binding molecules.	Iron	152-156	transferrin receptor	Homo sapiens	23-27
20133674-9	2010	The demonstration that TfR1 can bind HFt as well as Tf raises the possibility that this dual receptor function may coordinate the processing and use of iron by these iron-binding molecules.	Iron	166-170	transferrin receptor	Homo sapiens	23-27
19917294-5	2010	The capture and unambiguous assignment of all kinetic events associated with iron release by stopped-flow spectrofluorimetry, in the presence and in the absence of the TFR, unequivocally establish the decisive role of the TFR in promoting efficient and balanced iron release from both lobes of hTF during one endocytic cycle.	Iron	77-81	transferrin receptor	Homo sapiens	222-225
19917294-5	2010	The capture and unambiguous assignment of all kinetic events associated with iron release by stopped-flow spectrofluorimetry, in the presence and in the absence of the TFR, unequivocally establish the decisive role of the TFR in promoting efficient and balanced iron release from both lobes of hTF during one endocytic cycle.	Iron	262-266	transferrin receptor	Homo sapiens	222-225
19917294-6	2010	For the first time, the four microscopic rate constants required to accurately describe the kinetics of iron removal are reported for hTF with and without the TFR.	Iron	104-108	transferrin receptor	Homo sapiens	159-162
19917294-7	2010	Specifically, at pH 5.6, the TFR enhances the rate of iron release from the C-lobe (7-fold to 11-fold) and slows the rate of iron release from the N-lobe (6-fold to 15-fold), making them more equivalent and producing an increase in the net rate of iron removal from Fe(2)hTF.	Iron	54-58	transferrin receptor	Homo sapiens	29-32
19917294-7	2010	Specifically, at pH 5.6, the TFR enhances the rate of iron release from the C-lobe (7-fold to 11-fold) and slows the rate of iron release from the N-lobe (6-fold to 15-fold), making them more equivalent and producing an increase in the net rate of iron removal from Fe(2)hTF.	Iron	125-129	transferrin receptor	Homo sapiens	29-32
19917294-7	2010	Specifically, at pH 5.6, the TFR enhances the rate of iron release from the C-lobe (7-fold to 11-fold) and slows the rate of iron release from the N-lobe (6-fold to 15-fold), making them more equivalent and producing an increase in the net rate of iron removal from Fe(2)hTF.	Iron	125-129	transferrin receptor	Homo sapiens	29-32
20001966-0	2010	Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region.	Iron	0-4	frataxin	Homo sapiens	31-39
20001966-2	2010	Although its cellular function is still not fully clear, the fact that frataxin plays a crucial role in Fe-S assembly on the scaffold protein Isu is well accepted.	Iron	104-106	frataxin	Homo sapiens	71-79
20001966-4	2010	We report that frataxin iron-binding capacity is quite robust: even when five of the most conserved residues from the putative iron-binding region are altered, at least two iron atoms per monomer can be bound, although with decreased affinity.	Iron	24-28	frataxin	Homo sapiens	15-23
20001966-4	2010	We report that frataxin iron-binding capacity is quite robust: even when five of the most conserved residues from the putative iron-binding region are altered, at least two iron atoms per monomer can be bound, although with decreased affinity.	Iron	127-131	frataxin	Homo sapiens	15-23
20001966-4	2010	We report that frataxin iron-binding capacity is quite robust: even when five of the most conserved residues from the putative iron-binding region are altered, at least two iron atoms per monomer can be bound, although with decreased affinity.	Iron	127-131	frataxin	Homo sapiens	15-23
20055399-4	2010	At low temperature in dilute benzene matrices, Fe(eta(6)-C(6)H(6)) and Fe(eta(6)-C(6)H(6))(2) are the major products.	Iron	47-49	endothelin receptor type A	Homo sapiens	50-53
20055399-5	2010	At high iron concentrations, Fe(2)(eta(2)-C(6)H(6)) is also formed.	Iron	8-12	endothelin receptor type A	Homo sapiens	35-38
20055399-6	2010	In pure benzene at low temperature, Fe(eta(6)-C(6)H(6))(2) and Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) are formed.	Iron	36-38	endothelin receptor type A	Homo sapiens	39-42
20055399-6	2010	In pure benzene at low temperature, Fe(eta(6)-C(6)H(6))(2) and Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) are formed.	Iron	63-65	endothelin receptor type A	Homo sapiens	66-69
20055399-6	2010	In pure benzene at low temperature, Fe(eta(6)-C(6)H(6))(2) and Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) are formed.	Iron	63-65	endothelin receptor type A	Homo sapiens	66-69
20055399-8	2010	In pure benzene at 77 K, Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) is the major product, together with small amounts of Fe(eta(6)-C(6)H(6))(2) and iron clusters.	Iron	25-27	endothelin receptor type A	Homo sapiens	28-31
20055399-8	2010	In pure benzene at 77 K, Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) is the major product, together with small amounts of Fe(eta(6)-C(6)H(6))(2) and iron clusters.	Iron	25-27	endothelin receptor type A	Homo sapiens	45-48
20055399-8	2010	In pure benzene at 77 K, Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) is the major product, together with small amounts of Fe(eta(6)-C(6)H(6))(2) and iron clusters.	Iron	25-27	endothelin receptor type A	Homo sapiens	45-48
20055399-8	2010	In pure benzene at 77 K, Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) is the major product, together with small amounts of Fe(eta(6)-C(6)H(6))(2) and iron clusters.	Iron	115-117	endothelin receptor type A	Homo sapiens	28-31
20055399-8	2010	In pure benzene at 77 K, Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) is the major product, together with small amounts of Fe(eta(6)-C(6)H(6))(2) and iron clusters.	Iron	142-146	endothelin receptor type A	Homo sapiens	28-31
20055399-8	2010	In pure benzene at 77 K, Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) is the major product, together with small amounts of Fe(eta(6)-C(6)H(6))(2) and iron clusters.	Iron	142-146	endothelin receptor type A	Homo sapiens	45-48
20055399-8	2010	In pure benzene at 77 K, Fe(eta(6)-C(6)H(6))(eta(4)-C(6)H(6)) is the major product, together with small amounts of Fe(eta(6)-C(6)H(6))(2) and iron clusters.	Iron	142-146	endothelin receptor type A	Homo sapiens	45-48
20019189-7	2010	The MDM2 -309T &gt; G promoter polymorphism, determining increased MDM2 and lower p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma.	Iron	315-319	homeostatic iron regulator	Homo sapiens	200-203
20017200-12	2010	CONCLUSION: Huh-7 cells may represent a novel and valuable tool to investigate the role of altered HFE traffic in iron metabolism and pathogenesis of human HFE HC.	Iron	114-118	homeostatic iron regulator	Homo sapiens	99-102
20038143-5	2010	Only (MIL-53(Fe)-(CF(3))(2)) exhibits a nitrogen accessible porosity (S(BET) approximately 100 m(2) g(-1)).	Iron	13-15	delta/notch like EGF repeat containing	Homo sapiens	72-75
19800271-3	2010	The mutation results in a loss of post-transcriptional negative feedback exerted by the interaction between iron regulatory proteins 1, 2 (IRP1 and IRP2) and IRE, which leads to uncontrolled expression of L-ferritin.	Iron	108-112	aconitase 1	Homo sapiens	139-143
19819738-1	2010	Mutations in either the hereditary hemochromatosis protein, HFE, or transferrin receptor 2, TfR2, result in a similarly severe form of the most common type of iron overload disease called hereditary hemochromatosis.	Iron	159-163	homeostatic iron regulator	Homo sapiens	60-63
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	178-182	homeostatic iron regulator	Homo sapiens	35-38
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	178-182	transferrin receptor	Homo sapiens	40-44
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	233-237	homeostatic iron regulator	Homo sapiens	35-38
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	233-237	transferrin receptor	Homo sapiens	40-44
20090835-2	2010	In this disease, transcription of frataxin, a mitochondrial protein involved in iron homeostasis, is impaired, resulting in a significant reduction in mRNA and protein levels.	Iron	80-84	frataxin	Homo sapiens	34-42
20511703-9	2010	The findings suggested that diabetes mellitus (DM) induced the iron overload in the myocardium, at least in part by up-regulation of TfR.	Iron	63-67	transferrin receptor	Rattus norvegicus	133-136
19878966-2	2010	Dynamic runs for PVC and the mixture PVC and iron nanoparticles were firstly carried out by TGA-MS in order to study the influence of iron on the compounds evolved in the thermal degradation of PVC.	Iron	45-49	T-box transcription factor 1	Homo sapiens	92-95
20731136-1	2010	The article presents a classification of conditions, accompanied with increasing of iron accumulation of the liver cells, normal iron metabolism in the human body, etiology, epidemiology, multifactorial structure of the pathogenesis of HFE homozygous hemochromatosis, clinic of iron overload syndrome.	Iron	84-88	homeostatic iron regulator	Homo sapiens	236-239
20731136-1	2010	The article presents a classification of conditions, accompanied with increasing of iron accumulation of the liver cells, normal iron metabolism in the human body, etiology, epidemiology, multifactorial structure of the pathogenesis of HFE homozygous hemochromatosis, clinic of iron overload syndrome.	Iron	129-133	homeostatic iron regulator	Homo sapiens	236-239
22773607-0	2012	CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients.	Iron	41-45	homeostatic iron regulator	Homo sapiens	59-62
19780883-8	2010	During the iron reduction therapy, the plasma levels of tHODE but not t8-iso-PGF(2alpha) decreased and inversely its stereo-isomer ratio (ZE/EE) increased in parallel with the decreases of serum alanine aminotransferase, ferritin and alpha-fetoprotein.	Iron	11-15	glutamic--pyruvic transaminase	Homo sapiens	195-219
19939449-2	2010	We demonstrate that desferrioxamine (DFX), an iron chelator used in clinics for the treatment of iron overload, neoplasias, and Alzheimer disease, stimulates the expression and secretion of CCL20, a chemoattractant for immature dendritic cells, activated/memory T lymphocytes, and naive B cells, in primary human monocytes and monocyte-derived macrophages.	Iron	46-50	C-C motif chemokine ligand 20	Homo sapiens	190-195
19939449-2	2010	We demonstrate that desferrioxamine (DFX), an iron chelator used in clinics for the treatment of iron overload, neoplasias, and Alzheimer disease, stimulates the expression and secretion of CCL20, a chemoattractant for immature dendritic cells, activated/memory T lymphocytes, and naive B cells, in primary human monocytes and monocyte-derived macrophages.	Iron	97-101	C-C motif chemokine ligand 20	Homo sapiens	190-195
23192001-2	2012	Transferrin receptor (TfR) is an endocytic receptor and identified as tumor relative specific due to its overexpression on most tumor cells or tissues, and TfR binds and intakes of transferrin-iron complex.	Iron	193-197	transferrin receptor	Homo sapiens	0-20
19939449-3	2010	Iron chelation was part of the mechanism by which DFX induced CCL20, because addition of iron sulfate counteracted its stimulatory effects.	Iron	0-4	C-C motif chemokine ligand 20	Homo sapiens	62-67
19939449-7	2010	In conclusion, this study provides the first evidence that iron chelation can transcriptionally induce CCL20 in mononuclear phagocytes and identify the NF-kappaB binding site as a regulatory sequence of the CCL20 promoter that is activated by iron deprivation.	Iron	59-63	C-C motif chemokine ligand 20	Homo sapiens	103-108
19939449-7	2010	In conclusion, this study provides the first evidence that iron chelation can transcriptionally induce CCL20 in mononuclear phagocytes and identify the NF-kappaB binding site as a regulatory sequence of the CCL20 promoter that is activated by iron deprivation.	Iron	59-63	C-C motif chemokine ligand 20	Homo sapiens	207-212
19939449-7	2010	In conclusion, this study provides the first evidence that iron chelation can transcriptionally induce CCL20 in mononuclear phagocytes and identify the NF-kappaB binding site as a regulatory sequence of the CCL20 promoter that is activated by iron deprivation.	Iron	243-247	C-C motif chemokine ligand 20	Homo sapiens	207-212
23192001-2	2012	Transferrin receptor (TfR) is an endocytic receptor and identified as tumor relative specific due to its overexpression on most tumor cells or tissues, and TfR binds and intakes of transferrin-iron complex.	Iron	193-197	transferrin receptor	Homo sapiens	22-25
21117319-2	2010	Intracellular and systemic iron homeostasis is an important element in the defense against oxidative stress and is controlled by post-transcriptional regulatory mechanism IRP/IRE and hepcidin, a peptide that regulates iron absorption from diet and heme iron release by macrophages.	Iron	27-31	Wnt family member 2	Homo sapiens	171-174
21117319-2	2010	Intracellular and systemic iron homeostasis is an important element in the defense against oxidative stress and is controlled by post-transcriptional regulatory mechanism IRP/IRE and hepcidin, a peptide that regulates iron absorption from diet and heme iron release by macrophages.	Iron	218-222	Wnt family member 2	Homo sapiens	171-174
21117319-2	2010	Intracellular and systemic iron homeostasis is an important element in the defense against oxidative stress and is controlled by post-transcriptional regulatory mechanism IRP/IRE and hepcidin, a peptide that regulates iron absorption from diet and heme iron release by macrophages.	Iron	218-222	Wnt family member 2	Homo sapiens	171-174
23192001-2	2012	Transferrin receptor (TfR) is an endocytic receptor and identified as tumor relative specific due to its overexpression on most tumor cells or tissues, and TfR binds and intakes of transferrin-iron complex.	Iron	193-197	transferrin receptor	Homo sapiens	156-159
23169997-3	2012	In response, mucosal surfaces secrete lipocalin 2 (Lcn2), an innate immune protein that binds Ent to disrupt bacterial iron acquisition and promote acute inflammation during colonization.	Iron	119-123	lipocalin 2	Mus musculus	51-55
19748629-1	2009	Friedreich"s ataxia (FRDA) is an autosomal recessive disorder caused by mutations in the gene encoding frataxin, a mitochondrial protein implicated in iron metabolism.	Iron	151-155	frataxin	Homo sapiens	103-111
19748629-2	2009	Current evidence suggests that loss of frataxin causes iron overload in tissues, and increase in free-radical production leading to oxidation and inactivation of mitochondrial respiratory chain enzymes, particularly Complexes I, II, III and aconitase.	Iron	55-59	frataxin	Homo sapiens	39-47
22611049-0	2012	Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.	Iron	45-49	homeostatic iron regulator	Homo sapiens	106-109
19828835-1	2009	Transferrin receptor (TFR) 1 and 2 are expressed in the liver; TFR1 levels are regulated by cellular iron levels while TFR2 levels are regulated by transferrin saturation.	Iron	101-105	transferrin receptor	Homo sapiens	63-67
22259026-6	2012	Consistently, we found that nifedipine restores the number of TH-positive neurons reduced by iron dextran overload and prevents increase of iron content in the SN.	Iron	93-97	tyrosine hydroxylase	Rattus norvegicus	62-64
20082992-6	2009	Using the PD animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication in mice, we showed that DMT1 expression increased in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress and dopaminergic cell loss.	Iron	214-218	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	118-122
20082992-7	2009	A mutation in DMT1 that impairs iron transport protected rodents against parkinsonism-inducing neurotoxins MPTP and 6-hydroxydopamine (6-OHDA).	Iron	32-36	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	14-18
20082992-8	2009	This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD.	Iron	48-52	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	40-44
22915594-8	2012	Selective degradation of apo- over [(Fe(III)(2)-Y )(Fe(III)(2))]-beta(2) in lysates, similar iron-content in beta(2) immunoprecipitated from 3-AP-treated and untreated [(55)Fe]-prelabeled cells, and prolonged (12 h) stability of the inhibited beta(2) are most consistent with Y  loss being the predominant mode of inhibition, with beta(2) remaining iron-loaded and stable.	Iron	37-39	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	65-72
23062352-4	2012	We have investigated the transferrin receptor (TfR) pathway, which is not only essential for iron delivery but is also of importance for targeted drug delivery across cellular barriers at specific body sites, such as the brain that is impermeable to blood-borne substances.	Iron	93-97	transferrin receptor	Homo sapiens	25-45
19930544-9	2009	The tight junction protein occludin density decreased significantly (p &lt; 0.05) with increasing concentrations of metals on the particles (iron, copper and manganese, which were all strongly correlated with each other).	Iron	141-145	occludin	Homo sapiens	27-35
19878865-2	2009	reports that the iron-dependent 2-oxoglutarate dioxygenase or prolyl hydroxylase EglN2 induces Cyclin D1 levels, egging on breast tumorigenesis.	Iron	17-21	egl-9 family hypoxia inducible factor 2	Homo sapiens	81-86
19878865-2	2009	reports that the iron-dependent 2-oxoglutarate dioxygenase or prolyl hydroxylase EglN2 induces Cyclin D1 levels, egging on breast tumorigenesis.	Iron	17-21	cyclin D1	Homo sapiens	95-104
23062352-4	2012	We have investigated the transferrin receptor (TfR) pathway, which is not only essential for iron delivery but is also of importance for targeted drug delivery across cellular barriers at specific body sites, such as the brain that is impermeable to blood-borne substances.	Iron	93-97	transferrin receptor	Homo sapiens	47-50
23043051-7	2012	VTC2 and MDAR1, which are key enzymes in de novo ascorbate synthesis and ascorbate recycling, respectively, are likely responsible for the 10-fold increase in ascorbate content of iron-limited cells.	Iron	180-184	uncharacterized protein	Chlamydomonas reinhardtii	9-14
22692681-9	2012	Analysis of iron regulatory proteins (IRPs) reveals that, with respect to the controls, PKAN fibroblasts have a reduced amount of membrane-associated mRNA-bound IRP1, which responds imperfectly to iron.	Iron	197-201	aconitase 1	Homo sapiens	161-165
19643212-5	2009	Intracellular iron status was assessed by measuring iron content in cell layers and changes in transferrin receptor (TrfR) and ferritin gene and protein expression.	Iron	14-18	transferrin receptor	Rattus norvegicus	95-115
19643212-5	2009	Intracellular iron status was assessed by measuring iron content in cell layers and changes in transferrin receptor (TrfR) and ferritin gene and protein expression.	Iron	14-18	transferrin receptor	Rattus norvegicus	117-121
19643212-9	2009	Iron accumulation resulted in rapid and sustained down-regulation of TrfR gene and protein levels (within 24 h) and up-regulation of light and heavy chain ferritin protein levels at late differentiation (day 20, D20).	Iron	0-4	transferrin receptor	Rattus norvegicus	69-73
22609301-10	2012	In mammalian cells, the iron regulatory proteins IRP1, an Fe/S protein, and IRP2 act in a post-transcriptional fashion to adjust the cellular needs for iron.	Iron	24-28	aconitase 1	Homo sapiens	49-53
19820015-13	2009	CONCLUSION: Mutations in HFE gene, favoring iron overload and causing HH, could play an important role in the development of several phenotypes of primary HTG.	Iron	44-48	homeostatic iron regulator	Homo sapiens	25-28
22609301-10	2012	In mammalian cells, the iron regulatory proteins IRP1, an Fe/S protein, and IRP2 act in a post-transcriptional fashion to adjust the cellular needs for iron.	Iron	152-156	aconitase 1	Homo sapiens	49-53
22610083-1	2012	Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).	Iron	9-13	aconitase 1	Homo sapiens	77-81
19650690-6	2010	However, the mechanisms of iron homeostasis also are regulated by oxygen availability, with alterations in both hepcidin and IRP activity.	Iron	27-31	Wnt family member 2	Homo sapiens	125-128
22610083-1	2012	Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).	Iron	43-47	aconitase 1	Homo sapiens	77-81
19650690-9	2010	In addition, HIF-2alpha translation is controlled by IRP activity, providing another level of interdependence between iron and oxygen homeostasis.	Iron	118-122	Wnt family member 2	Homo sapiens	53-56
19501959-3	2009	Acid Red 2 solution was decolorized by electrolysis using iron as anode.	Iron	58-62	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	5-10
22791549-3	2012	Decreased frataxin function leads to decreased iron-sulfur cluster formation, mitochondrial iron accumulation, cytosolic iron depletion, oxidative stress, and mitochondrial dysfunction.	Iron	47-51	frataxin	Homo sapiens	10-18
19762596-3	2009	We found that a SKP1-CUL1-FBXL5 ubiquitin ligase protein complex associates with and promotes the iron-dependent ubiquitination and degradation of IRP2.	Iron	98-102	cullin 1	Homo sapiens	21-25
22884366-0	2012	Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.	Iron	8-12	APC regulator of WNT signaling pathway	Homo sapiens	58-61
19762597-1	2009	Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.	Iron	9-13	aconitase 1	Homo sapiens	205-209
19762597-1	2009	Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.	Iron	114-118	aconitase 1	Homo sapiens	205-209
19762597-1	2009	Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.	Iron	114-118	aconitase 1	Homo sapiens	205-209
20130467-3	2010	Intracellular iron uptake is regulated by the transferrin receptor (TfR), and the activity of artemisinin depends on the availability of iron.	Iron	14-18	transferrin receptor	Homo sapiens	46-66
20130467-3	2010	Intracellular iron uptake is regulated by the transferrin receptor (TfR), and the activity of artemisinin depends on the availability of iron.	Iron	14-18	transferrin receptor	Homo sapiens	68-71
20411049-0	2009	Neutrophil elastase increases airway epithelial nonheme iron levels.	Iron	56-60	elastase, neutrophil expressed	Homo sapiens	0-19
22884366-2	2012	In this study, we show that after Apc deletion, the cellular iron acquisition proteins TfR1 and DMT1 are rapidly induced.	Iron	61-65	APC regulator of WNT signaling pathway	Homo sapiens	34-37
20411049-2	2009	We hypothesized that NE exposure generates reactive oxygen species by increasing lung non-heme iron.	Iron	95-99	elastase, neutrophil expressed	Homo sapiens	21-23
20411049-6	2009	To investigate the mechanism of NE-induced increased iron levels, we exposed normal human airway epithelial cells to either NE or control vehicle in the presence or absence of ferritin, and quantified intracellular iron uptake using calcein fluorescence and ICP mass spectroscopy.	Iron	53-57	elastase, neutrophil expressed	Homo sapiens	32-34
20373367-0	2010	Hemochromatosis gene (HFE) mutations and cancer risk: expanding the clinical manifestations of hereditary iron overload.	Iron	106-110	homeostatic iron regulator	Homo sapiens	22-25
22884366-2	2012	In this study, we show that after Apc deletion, the cellular iron acquisition proteins TfR1 and DMT1 are rapidly induced.	Iron	61-65	transferrin receptor	Homo sapiens	87-91
20411049-6	2009	To investigate the mechanism of NE-induced increased iron levels, we exposed normal human airway epithelial cells to either NE or control vehicle in the presence or absence of ferritin, and quantified intracellular iron uptake using calcein fluorescence and ICP mass spectroscopy.	Iron	215-219	elastase, neutrophil expressed	Homo sapiens	32-34
20411049-8	2009	We demonstrated in vitro that NE increased intracellular non-heme iron levels and degraded ferritin.	Iron	66-70	elastase, neutrophil expressed	Homo sapiens	30-32
22786765-2	2012	Lipocalin 2 (Lcn2; siderocalin, 24p3) plays a central role in iron transport.	Iron	62-66	lipocalin 2	Mus musculus	0-11
20411049-9	2009	Our results suggest that NE digests ferritin increasing the extracellular iron pool available for cellular uptake.	Iron	74-78	elastase, neutrophil expressed	Homo sapiens	25-27
22786765-2	2012	Lipocalin 2 (Lcn2; siderocalin, 24p3) plays a central role in iron transport.	Iron	62-66	lipocalin 2	Mus musculus	13-17
22786765-8	2012	Desferroxamine, an iron chelator, significantly protects Lcn2KO mice from LPS-induced toxicity, including mortality, suggesting that Lcn2 may act as an antioxidant in vivo by regulating iron homeostasis.	Iron	19-23	lipocalin 2	Mus musculus	133-137
19591830-2	2009	Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating that HFE regulates hepcidin.	Iron	19-23	homeostatic iron regulator	Homo sapiens	170-173
22786765-8	2012	Desferroxamine, an iron chelator, significantly protects Lcn2KO mice from LPS-induced toxicity, including mortality, suggesting that Lcn2 may act as an antioxidant in vivo by regulating iron homeostasis.	Iron	186-190	lipocalin 2	Mus musculus	133-137
22786765-9	2012	Thus, Lcn2-mediated regulation of labile iron protects the host against sepsis.	Iron	41-45	lipocalin 2	Mus musculus	6-10
22847425-9	2012	We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.	Iron	90-94	Transferrin 1	Drosophila melanogaster	107-118
19620254-2	2009	We have shown previously that activation of AMP-activated protein kinase (AMPK) protects hepatocytes from AA + iron-induced apoptosis.	Iron	111-115	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	44-72
19620254-2	2009	We have shown previously that activation of AMP-activated protein kinase (AMPK) protects hepatocytes from AA + iron-induced apoptosis.	Iron	111-115	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	74-78
19620254-12	2009	Thus, resveratrol protects cells from AA + iron-induced ROS production and mitochondrial dysfunction through AMPK-mediated inhibitory phosphorylation of GSK3beta downstream of poly(ADP-ribose)polymerase-LKB1 pathway.	Iron	43-47	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	109-113
19620254-12	2009	Thus, resveratrol protects cells from AA + iron-induced ROS production and mitochondrial dysfunction through AMPK-mediated inhibitory phosphorylation of GSK3beta downstream of poly(ADP-ribose)polymerase-LKB1 pathway.	Iron	43-47	glycogen synthase kinase 3 beta	Homo sapiens	153-161
22847425-9	2012	We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.	Iron	90-94	Transferrin 1	Drosophila melanogaster	107-118
22847425-9	2012	We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.	Iron	90-94	Transferrin 1	Drosophila melanogaster	107-118
19675150-7	2009	MAR1 overexpression lines are slightly chlorotic, and chlorosis is rescued by exogenous iron.	Iron	88-92	iron-regulated protein 3	Arabidopsis thaliana	0-4
22362121-2	2012	The presence of hemochromatosis gene (HFE) mutations might exacerbate iron toxicity in the post-transplant setting.	Iron	70-74	homeostatic iron regulator	Homo sapiens	38-41
19675150-8	2009	MAR1 expression is also down-regulated by low iron.	Iron	46-50	iron-regulated protein 3	Arabidopsis thaliana	0-4
19675150-9	2009	These data suggest that MAR1 is a plastid transporter that is likely to be involved in cellular iron homeostasis and allows opportunistic entry of multiple antibiotics into the chloroplast.	Iron	96-100	iron-regulated protein 3	Arabidopsis thaliana	24-28
22362121-8	2012	The multifactorial iron-overloaded state in HSCT recipients might affect the phenotypic expression of HFE mutations and alter the severity of clinical presentation.	Iron	19-23	homeostatic iron regulator	Homo sapiens	102-105
19786205-3	2009	The most common X-linked sideroblastic anemia (XLSA), due to mutations of the first enzyme of the heme synthetic pathway, delta-aminolevulinic acid synthase 2 (ALAS2), has linked heme deficiency to mitochondrial iron accumulation.	Iron	212-216	5'-aminolevulinate synthase 2	Homo sapiens	122-158
19786205-3	2009	The most common X-linked sideroblastic anemia (XLSA), due to mutations of the first enzyme of the heme synthetic pathway, delta-aminolevulinic acid synthase 2 (ALAS2), has linked heme deficiency to mitochondrial iron accumulation.	Iron	212-216	5'-aminolevulinate synthase 2	Homo sapiens	160-165
19786205-5	2009	As recently occurred with the discovery of the SLC25A38-related sideroblastic anemia, the identification of the genes responsible for as yet uncharacterized forms will provide further insights into mitochondrial iron metabolism of erythroid cells and the pathophysiology of sideroblastic anemia.	Iron	212-216	solute carrier family 25 member 38	Homo sapiens	47-55
22362121-9	2012	The impact of HFE genotype on iron parameters and transplant-related morbidity and mortality should be validated with further studies.	Iron	30-34	homeostatic iron regulator	Homo sapiens	14-17
22434419-5	2012	Blocking holo-Tf binding with an anti-TfR antibody significantly decreases the reduction of iron from transferrin by hBMVEC, suggesting that holo-Tf needs to bind to TfR in order for efficient reduction to occur.	Iron	92-96	transferrin receptor	Homo sapiens	166-169
22700084-4	2012	The effect of BHAPI and HAPI on cellular iron status was assessed by monitoring the mRNA level of the transferrin receptor.	Iron	41-45	transferrin receptor	Homo sapiens	102-122
19682329-1	2009	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1) but has distinct functions from TfR1 in iron homeostasis.	Iron	118-122	transferrin receptor	Homo sapiens	72-76
19682329-1	2009	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1) but has distinct functions from TfR1 in iron homeostasis.	Iron	118-122	transferrin receptor	Homo sapiens	110-114
19596281-6	2009	Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age.	Iron	108-112	transferrin receptor	Mus musculus	16-38
19596281-6	2009	Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age.	Iron	108-112	transferrin receptor	Mus musculus	40-44
19596281-6	2009	Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age.	Iron	153-157	transferrin receptor	Mus musculus	16-38
19596281-6	2009	Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age.	Iron	153-157	transferrin receptor	Mus musculus	40-44
22710690-3	2012	Significant fluorescence enhancement is observed with MS1 in the presence of Hg(2+); the metal ions Ag(+), Ca(2+), Cd(2+), Co(2+), Cu(2+), Fe(2+), Fe(3+), K(+), Mg(2+), Mn(2+), Ni(2+), Pb(2+), and Zn(2+) cause only minor changes in the fluorescence of the system.	Iron	139-141	MS	Homo sapiens	54-57
19540797-1	2009	A new pyridine-2,6-dicarboxylate iron(III)/iron(II) complex [Fe(phen)(3)][Fe(2)(PDC)(4)].3CH(3)OH was synthesized and characterized (where PDC=pyridine-2,6-dicarboxylate, phen=1,10-phenanthroline) by using elemental analysis, IR spectroscopy and thermal analyses (TGA and DTA).	Iron	33-37	T-box transcription factor 1	Homo sapiens	264-267
22710690-3	2012	Significant fluorescence enhancement is observed with MS1 in the presence of Hg(2+); the metal ions Ag(+), Ca(2+), Cd(2+), Co(2+), Cu(2+), Fe(2+), Fe(3+), K(+), Mg(2+), Mn(2+), Ni(2+), Pb(2+), and Zn(2+) cause only minor changes in the fluorescence of the system.	Iron	147-149	MS	Homo sapiens	54-57
19540797-1	2009	A new pyridine-2,6-dicarboxylate iron(III)/iron(II) complex [Fe(phen)(3)][Fe(2)(PDC)(4)].3CH(3)OH was synthesized and characterized (where PDC=pyridine-2,6-dicarboxylate, phen=1,10-phenanthroline) by using elemental analysis, IR spectroscopy and thermal analyses (TGA and DTA).	Iron	43-47	T-box transcription factor 1	Homo sapiens	264-267
22678361-0	2012	MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.	Iron	24-28	MMS19 cytosolic iron-sulfur assembly component	Mus musculus	0-5
19165552-3	2009	Among other functions, frataxin is an iron chaperone central for the assembly of iron-sulfur clusters in mitochondria; its reduction is associated with iron accumulation in mitochondria, increased cellular sensitivity to oxidative stress and cell damage.	Iron	38-42	frataxin	Homo sapiens	23-31
22678361-3	2012	Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18.	Iron	69-73	MMS19 cytosolic iron-sulfur assembly component	Mus musculus	26-31
19165552-3	2009	Among other functions, frataxin is an iron chaperone central for the assembly of iron-sulfur clusters in mitochondria; its reduction is associated with iron accumulation in mitochondria, increased cellular sensitivity to oxidative stress and cell damage.	Iron	81-85	frataxin	Homo sapiens	23-31
19165552-3	2009	Among other functions, frataxin is an iron chaperone central for the assembly of iron-sulfur clusters in mitochondria; its reduction is associated with iron accumulation in mitochondria, increased cellular sensitivity to oxidative stress and cell damage.	Iron	81-85	frataxin	Homo sapiens	23-31
19764250-7	2009	The longevity and long-term effectiveness of the PRB appears to be primarily limited by reduced corrosion rates of the ZVI-shavings because of the thick layers of Fe-hydroxides.	Iron	119-122	RB transcriptional corepressor 1	Homo sapiens	49-52
22678361-5	2012	In the absence of MMS19, a failure to transfer Fe-S clusters to target proteins is associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been knocked out.	Iron	47-51	MMS19 cytosolic iron-sulfur assembly component	Mus musculus	167-172
22678361-6	2012	We propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair.	Iron	60-62	MMS19 cytosolic iron-sulfur assembly component	Mus musculus	16-21
22763969-1	2012	Transferrin receptor 1 (CD71) is a transmembrane glycoprotein responsible for cellular iron uptake.	Iron	87-91	transferrin receptor	Homo sapiens	24-28
19608676-2	2009	Here we describe the temporal relationship of serum hepcidin, serum iron and cytokines in a patient with HFE-related (C282Y homozygous) hereditary hemochromatosis who was treated for an auto-inflammatory condition, i.e. variant Schnitzler"s syndrome, with the potent anti-inflammatory cytokine inter-leukin-1 receptor antagonist (IL-1ra, anakinra).	Iron	68-72	homeostatic iron regulator	Homo sapiens	105-108
22616905-1	2012	As the transport protein for iron, transferrin can trigger cellular endocytosis once binding to its receptor (TfR) on the cell membrane.	Iron	29-33	transferrin receptor	Mus musculus	110-113
19734422-4	2009	In this study we investigated the influence that mutations in HAMP and/or hemocromatosis (HFE) genes might exert on iron metabolism in a group of poly-transfused thalassemic patients in preparation for bone marrow transplantation.	Iron	116-120	homeostatic iron regulator	Homo sapiens	90-93
19491103-2	2009	Analysis of highly conserved components of the yeast ISC assembly machinery shows that the iron-chaperone, Yfh1, and the sulfur-donor complex, Nfs1-Isd11, directly bind to each other.	Iron	91-95	NFS1 cysteine desulfurase	Homo sapiens	143-147
22556412-0	2012	Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination.	Iron	0-4	activation induced cytidine deaminase	Homo sapiens	14-51
19491103-5	2009	Binding of Yfh1 to Nfs1-Isd11 or Isu1 requires oligomerization of Yfh1 and can occur in an iron-independent manner.	Iron	91-95	NFS1 cysteine desulfurase	Homo sapiens	19-23
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	33-37	activation induced cytidine deaminase	Homo sapiens	306-309
19132541-2	2009	In Saccharomyces cerevisiae, the ABC-type transport system Atm1p is involved in export of iron-sulfur clusters from mitochondria into the cytoplasm for assembly of cytoplasmic iron-sulfur containing proteins.	Iron	90-94	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	59-64
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	33-37	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	311-322
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	43-45	activation induced cytidine deaminase	Homo sapiens	306-309
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	43-45	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	311-322
19678841-2	2009	Disruption of the Atx1-Ccc2 route leads to cell growth arrest in a copper-and-iron-limited medium, a phenotype allowing complementation studies.	Iron	78-82	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	23-27
22404220-7	2012	RESULTS: Treatment with LTCC, TTCC, DMT1 blockers, and DFO reduced cardiac iron deposit, cardiac malondialdehyde (MDA), plasma non-transferrin-bound iron, and improved heart rate variability and left ventricular (LV) function in thalassemic mice with iron overload.	Iron	75-79	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	36-40
22404220-7	2012	RESULTS: Treatment with LTCC, TTCC, DMT1 blockers, and DFO reduced cardiac iron deposit, cardiac malondialdehyde (MDA), plasma non-transferrin-bound iron, and improved heart rate variability and left ventricular (LV) function in thalassemic mice with iron overload.	Iron	149-153	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	36-40
19117676-5	2009	BET indicated that Fe-M samples possessed higher surface area compared to the parent Na-M. Photocatalytic degradation of EDTA was carried out in presence of the prepared Fe-M catalysts.	Iron	19-21	delta/notch like EGF repeat containing	Homo sapiens	0-3
22404220-7	2012	RESULTS: Treatment with LTCC, TTCC, DMT1 blockers, and DFO reduced cardiac iron deposit, cardiac malondialdehyde (MDA), plasma non-transferrin-bound iron, and improved heart rate variability and left ventricular (LV) function in thalassemic mice with iron overload.	Iron	149-153	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	36-40
19117676-5	2009	BET indicated that Fe-M samples possessed higher surface area compared to the parent Na-M. Photocatalytic degradation of EDTA was carried out in presence of the prepared Fe-M catalysts.	Iron	170-172	delta/notch like EGF repeat containing	Homo sapiens	0-3
22404220-8	2012	Only TTCC and DMT1 blockers and DFO reduced liver iron accumulation, liver MDA, plasma MDA, and decreased mortality rate in iron-overloaded thalassemic mice.	Iron	50-54	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	14-18
22404220-8	2012	Only TTCC and DMT1 blockers and DFO reduced liver iron accumulation, liver MDA, plasma MDA, and decreased mortality rate in iron-overloaded thalassemic mice.	Iron	124-128	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	14-18
22404220-9	2012	CONCLUSIONS: DMT1, LTCC, and TTCC played important roles for iron entry in the thalassemic heart under an iron-overloaded condition.	Iron	61-65	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	13-17
19656448-0	2009	HFE gene mutations in patients with altered iron metabolism in Argentina.	Iron	44-48	homeostatic iron regulator	Homo sapiens	0-3
19568430-0	2009	Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.	Iron	48-52	prion protein	Mus musculus	0-13
22404220-9	2012	CONCLUSIONS: DMT1, LTCC, and TTCC played important roles for iron entry in the thalassemic heart under an iron-overloaded condition.	Iron	106-110	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	13-17
19568430-0	2009	Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.	Iron	48-52	prion protein	Mus musculus	15-18
22322235-8	2012	Those extrahepatic tissues that are typically involved in pathological siderosis in neonatal hemochromatosis, whether from normal or diseased newborns, consistently expressed solute carrier family 39 (zinc transporter), member 14 (ZIP14) for non-transferrin-bound iron uptake and expressed little ferroportin for iron export.	Iron	264-268	solute carrier family 39 member 14	Homo sapiens	231-236
19568430-0	2009	Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.	Iron	94-98	prion protein	Mus musculus	0-13
19568430-0	2009	Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.	Iron	94-98	prion protein	Mus musculus	15-18
19568430-0	2009	Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.	Iron	94-98	prion protein	Mus musculus	87-90
22322235-8	2012	Those extrahepatic tissues that are typically involved in pathological siderosis in neonatal hemochromatosis, whether from normal or diseased newborns, consistently expressed solute carrier family 39 (zinc transporter), member 14 (ZIP14) for non-transferrin-bound iron uptake and expressed little ferroportin for iron export.	Iron	313-317	solute carrier family 39 member 14	Homo sapiens	231-236
19568430-2	2009	In previous reports we demonstrated that PrP mediates cellular iron uptake and transport, and aggregation of PrP to the disease causing PrP-scrapie (PrP(Sc)) form results in imbalance of iron homeostasis in prion disease affected human and animal brains.	Iron	63-67	prion protein	Mus musculus	41-44
22456661-9	2012	Positive predictive values of ID based on the other iron indicators in predicting ID based on the multiple-criteria model were highest for ferritin and TfR.	Iron	52-56	transferrin receptor	Homo sapiens	152-155
19413286-2	2009	Recombinant human Glx2 tightly binds nearly 1 equiv each of Zn(II) and Fe.	Iron	71-73	hydroxyacylglutathione hydrolase	Homo sapiens	18-22
19413286-4	2009	EPR studies suggest that most of the iron in recombinant Glx2 is Fe(II).	Iron	37-41	hydroxyacylglutathione hydrolase	Homo sapiens	57-61
22298416-0	2012	Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-alpha and TGF-beta1.	Iron	0-4	transforming growth factor, beta 1	Mus musculus	90-99
18506200-13	2009	Although TfR has been promoted as an iron indicator that is uninfluenced by the APR, TfR concentrations were depressed among anemic APR-positive women.	Iron	37-41	transferrin receptor	Homo sapiens	9-12
22298416-5	2012	Here we report that the proinflammatory cytokine TNF-alpha, and the anti-inflammatory cytokine TGF-beta1 affect iron homeostasis in astrocytes and microglia in distinct ways.	Iron	112-116	transforming growth factor, beta 1	Mus musculus	95-104
22298416-10	2012	In particular, TNF-alpha caused an increase in iron uptake and retention by both astrocytes and microglia, while TGF-beta1 promoted iron efflux from astrocytes but caused iron retention in microglia.	Iron	132-136	transforming growth factor, beta 1	Mus musculus	113-122
22298416-10	2012	In particular, TNF-alpha caused an increase in iron uptake and retention by both astrocytes and microglia, while TGF-beta1 promoted iron efflux from astrocytes but caused iron retention in microglia.	Iron	132-136	transforming growth factor, beta 1	Mus musculus	113-122
22278021-8	2012	These effects are mediated through the action of intracellular iron to induce lipocalin-2.	Iron	63-67	lipocalin 2	Rattus norvegicus	78-89
19290554-3	2009	This is in part due to the complexity of this process, which is influenced by lobe-lobe interactions, the transferrin receptor (TFR), the salt effect, the presence of a chelator, and acidification within the endosome, resulting in iron release.	Iron	231-235	transferrin receptor	Homo sapiens	106-126
19290554-3	2009	This is in part due to the complexity of this process, which is influenced by lobe-lobe interactions, the transferrin receptor (TFR), the salt effect, the presence of a chelator, and acidification within the endosome, resulting in iron release.	Iron	231-235	transferrin receptor	Homo sapiens	128-131
22228247-3	2012	METHODS: A primary care-based cohort of 20,306 participants (Hemochromatosis and Iron Overload Study, Ontario site) were tested for the C282Y and H63D mutations of the HFE gene and for abnormal serum ferritin (SF) and transferrin saturation levels.	Iron	81-85	homeostatic iron regulator	Homo sapiens	168-171
19290554-6	2009	We have used a combination of steady-state fluorescence and urea gels to evaluate the effect of conformation, pH, time, and the soluble portion of the TFR (sTFR) on iron release from each lobe of hTF.	Iron	165-169	transferrin receptor	Homo sapiens	151-154
19269970-1	2009	Iron-sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding and cytosolic aconitase (c-acon) forms controls vertebrate iron homeostasis.	Iron	0-4	aconitase 1	Homo sapiens	49-74
19269970-1	2009	Iron-sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding and cytosolic aconitase (c-acon) forms controls vertebrate iron homeostasis.	Iron	0-4	aconitase 1	Homo sapiens	76-80
19269970-1	2009	Iron-sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding and cytosolic aconitase (c-acon) forms controls vertebrate iron homeostasis.	Iron	49-53	aconitase 1	Homo sapiens	76-80
19269970-11	2009	Taken together, our results support a model wherein Ser(138) phosphorylation sensitizes IRP1/c-acon to decreased iron availability by allowing the [4Fe-4S](2+) cluster to cycle with [3Fe-4S](0) in the absence of cluster perturbants, indicating that regulation can be initiated merely by changes in iron availability.	Iron	113-117	aconitase 1	Homo sapiens	88-92
19269970-11	2009	Taken together, our results support a model wherein Ser(138) phosphorylation sensitizes IRP1/c-acon to decreased iron availability by allowing the [4Fe-4S](2+) cluster to cycle with [3Fe-4S](0) in the absence of cluster perturbants, indicating that regulation can be initiated merely by changes in iron availability.	Iron	298-302	aconitase 1	Homo sapiens	88-92
19454351-5	2009	Resistance to lipocalin-2, mediated by the iroBCDE iroN locus, conferred a competitive advantage to the bacterium in colonizing the inflamed intestine of wild-type but not of lipocalin-2-deficient mice.	Iron	51-55	lipocalin 2	Mus musculus	14-25
19352007-5	2009	Using these mice, we found that HIF-1alpha was not necessary for iron absorption, whereas HIF-2alpha played a crucial role in maintaining iron balance in the organism by directly regulating the transcription of the gene encoding divalent metal transporter 1 (DMT1), the principal intestinal iron transporter.	Iron	138-142	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	229-257
19148135-5	2009	Ultrastructurally, abnormal and iron-laden mitochondria were abundant, especially in RARS patients.	Iron	32-36	arginyl-tRNA synthetase 1	Homo sapiens	85-89
19329565-4	2009	Despite the improved nutrient status of plants grown in Fe-limited medium under elevated CO(2), the Fe-deficiency-induced responses in roots, including ferric chelate reductase activity, proton secretion, subapical root hair development, and the expression of FER, FRO1, and IRT genes, were all greater than plants grown in the ambient CO(2).	Iron	100-102	bHLH transcriptional regulator	Solanum lycopersicum	260-263
19329565-4	2009	Despite the improved nutrient status of plants grown in Fe-limited medium under elevated CO(2), the Fe-deficiency-induced responses in roots, including ferric chelate reductase activity, proton secretion, subapical root hair development, and the expression of FER, FRO1, and IRT genes, were all greater than plants grown in the ambient CO(2).	Iron	100-102	ferric-chelate reductase	Solanum lycopersicum	265-269
19380292-4	2009	This report discusses the pathophysiology of iron accumulation in patients with hemolytic anemia combined with HFE C282Y homozygosity.	Iron	45-49	homeostatic iron regulator	Homo sapiens	111-114
19281164-1	2009	The nonheme iron enzyme phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase catalyze the hydroxylation of their aromatic amino acid substrates using a tetrahydropterin as the source of electrons.	Iron	12-16	phenylalanine hydroxylase	Homo sapiens	24-49
19281173-4	2009	On a biologically relevant time scale (2-3 min), the factors critical to iron release include pH, anions, a chelator, and the interaction of hTF with the TFR.	Iron	73-77	transferrin receptor	Homo sapiens	154-157
19281173-5	2009	Previous work, in which the increase in the intrinsic fluorescence signal was used to monitor iron release from the hTF/TFR complex, established that the TFR significantly enhances the rate of iron release from the C-lobe of hTF.	Iron	94-98	transferrin receptor	Homo sapiens	120-123
19281173-5	2009	Previous work, in which the increase in the intrinsic fluorescence signal was used to monitor iron release from the hTF/TFR complex, established that the TFR significantly enhances the rate of iron release from the C-lobe of hTF.	Iron	94-98	transferrin receptor	Homo sapiens	154-157
19281173-5	2009	Previous work, in which the increase in the intrinsic fluorescence signal was used to monitor iron release from the hTF/TFR complex, established that the TFR significantly enhances the rate of iron release from the C-lobe of hTF.	Iron	193-197	transferrin receptor	Homo sapiens	120-123
19281173-5	2009	Previous work, in which the increase in the intrinsic fluorescence signal was used to monitor iron release from the hTF/TFR complex, established that the TFR significantly enhances the rate of iron release from the C-lobe of hTF.	Iron	193-197	transferrin receptor	Homo sapiens	154-157
19281173-10	2009	Two rate constants are observed for the FeC hTF control and the four Trp mutants in complex with the TFR: k(obsC1) reports conformational changes in the C-lobe initiated by the TFR, and k(obsC2) is ascribed to iron release.	Iron	210-214	transferrin receptor	Homo sapiens	101-104
19281173-10	2009	Two rate constants are observed for the FeC hTF control and the four Trp mutants in complex with the TFR: k(obsC1) reports conformational changes in the C-lobe initiated by the TFR, and k(obsC2) is ascribed to iron release.	Iron	210-214	transferrin receptor	Homo sapiens	177-180
19519625-3	2009	A subsequent genetic screen confirmed the importance of oxidative stress and a molecular dissection of the steps in the cellular metabolism of reactive oxygen species revealed that the iron-binding protein ferritin and the H(2)O(2) scavenger catalase are the most potent suppressors of the toxicity of wild-type and Arctic (E22G) Abeta(1-42).	Iron	185-189	Ferritin 1 heavy chain homologue	Drosophila melanogaster	206-214
19519625-5	2009	The effect of iron appears to be mediated by oxidative stress as ferritin heavy chain co-expression reduced carbonyl levels in Abeta(1-42) flies by 65% and restored the survival and locomotion function to normal.	Iron	14-18	Ferritin 1 heavy chain homologue	Drosophila melanogaster	65-85
19066337-3	2009	One example of this pleiotropy is the Izh2p-dependent repression of FET3, a gene involved in iron-uptake.	Iron	93-97	ferroxidase FET3	Saccharomyces cerevisiae S288C	68-72
19731820-1	2009	OBJECTIVE: To detect the incidence of the HFE gene C282Y and H63D mutations in patients with myelodysplastic syndromes (MDS) and aplastic anemia (AA), and analyze the relationship of these mutations with iron metabolism, and organs impairment from iron overload.	Iron	204-208	homeostatic iron regulator	Homo sapiens	42-45
19731820-1	2009	OBJECTIVE: To detect the incidence of the HFE gene C282Y and H63D mutations in patients with myelodysplastic syndromes (MDS) and aplastic anemia (AA), and analyze the relationship of these mutations with iron metabolism, and organs impairment from iron overload.	Iron	248-252	homeostatic iron regulator	Homo sapiens	42-45
19257911-4	2009	esxG and esxH are part of ESAT-6 cluster 3, whose expression was already known to be induced by iron starvation.	Iron	96-100	ESAT-6 protein EsxA	Mycobacterium tuberculosis H37Rv	26-32
19257911-6	2009	In contrast to what we had observed in M. tuberculosis, we found that in M. smegmatis ESAT-6 cluster 3 responds only to iron and not to zinc.	Iron	120-124	ESAT-6 protein EsxA	Mycobacterium tuberculosis H37Rv	86-92
19228364-10	2009	The decrease in expression of a gene identified as "similar to calreticulin," while not statistically significant, was consistent with the findings of other investigators that suggest iron plays a role in calreticulin expression.	Iron	184-188	calreticulin	Canis lupus familiaris	63-75
19228364-10	2009	The decrease in expression of a gene identified as "similar to calreticulin," while not statistically significant, was consistent with the findings of other investigators that suggest iron plays a role in calreticulin expression.	Iron	184-188	calreticulin	Canis lupus familiaris	205-217
19146986-2	2009	The vast majority of HH patients are homozygous for the C282Y mutation in HFE, a non-classical MHC class-I gene located in chromosome 6, whose role in the regulation of systemic iron metabolism is still not completely understood.	Iron	178-182	homeostatic iron regulator	Homo sapiens	74-77
19228389-2	2009	Variants of HFE are relatively common in the general population and are most commonly associated with iron overload, but can promote subclinical cellular iron loading even in the absence of clinically identified disease.	Iron	102-106	homeostatic iron regulator	Homo sapiens	12-15
19228389-2	2009	Variants of HFE are relatively common in the general population and are most commonly associated with iron overload, but can promote subclinical cellular iron loading even in the absence of clinically identified disease.	Iron	154-158	homeostatic iron regulator	Homo sapiens	12-15
19228389-8	2009	RESULTS: Expression of the HFE variants altered the labile iron pool in SH-SY5Y cells.	Iron	59-63	homeostatic iron regulator	Homo sapiens	27-30
19123805-5	2009	Films constituted by more than nine PSS/PAH bilayers are still permeable to hexacyanoferrate(II) ions, Fe(CN)(6)4-, whatever the nature of the supporting salt anion.	Iron	103-105	phenylalanine hydroxylase	Homo sapiens	40-43
19061943-9	2009	However, the mRNA expression for ceruloplasmin and divalent metal transporter 1 (DMT1) IRE(+) in the adenomas was altered independently of iron status, and the dysregulation may contribute to diminished iron content.	Iron	139-143	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	81-85
19061943-9	2009	However, the mRNA expression for ceruloplasmin and divalent metal transporter 1 (DMT1) IRE(+) in the adenomas was altered independently of iron status, and the dysregulation may contribute to diminished iron content.	Iron	203-207	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	51-79
19061943-9	2009	However, the mRNA expression for ceruloplasmin and divalent metal transporter 1 (DMT1) IRE(+) in the adenomas was altered independently of iron status, and the dysregulation may contribute to diminished iron content.	Iron	203-207	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	81-85
19154341-2	2009	The cause of the disease is a defect in mitochondrial frataxin, an iron chaperone involved in the maturation of Fe-S cluster proteins.	Iron	67-71	frataxin	Homo sapiens	54-62
19820972-3	2010	Structurally, neuroglobin enjoys unique features, such as bis-histidyl coordination to heme iron in the absence of exogenous ligand, heme orientational heterogeneity, and a heme sliding mechanism accompanying ligand binding.	Iron	92-96	neuroglobin	Mus musculus	14-25
20176015-1	2010	Viperin, an interferon-inducible antiviral protein, is shown to bind an iron-sulfur cluster, based on iron analysis as well as UV-Vis and electron paramagnetic resonance spectroscopic data.	Iron	72-76	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
20176015-1	2010	Viperin, an interferon-inducible antiviral protein, is shown to bind an iron-sulfur cluster, based on iron analysis as well as UV-Vis and electron paramagnetic resonance spectroscopic data.	Iron	102-106	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
20110177-12	2010	However hemodynamic signals such as LVEF alterations and iron mobilization do appear to affect changes in cystatin C concentration.	Iron	57-61	cystatin C	Homo sapiens	106-116
20042601-7	2010	Using x-ray absorption spectroscopy, we demonstrate that nickel binds to the same site in ABH2 as iron, and replacement of the iron by nickel does not prevent the binding of the cofactor 2-oxoglutarate.	Iron	127-131	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	90-94
20042601-8	2010	Finally, we show that nickel ions target and inhibit JMJD1A in intact cells, and disruption of the iron-binding site decreases binding of nickel ions to ABH2 in intact cells.	Iron	99-103	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	153-157
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	51-55	transferrin receptor	Homo sapiens	174-194
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	51-55	transferrin receptor	Homo sapiens	196-200
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	transferrin receptor	Homo sapiens	174-194
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	transferrin receptor	Homo sapiens	196-200
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	transferrin receptor	Homo sapiens	174-194
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	transferrin receptor	Homo sapiens	196-200
20393584-2	2010	Iron concentrations can rise to toxic levels in mitochondria of excitable cells, often leaving the cytosol iron-depleted, in some forms of neurodegeneration with brain accumulation (NBIA) or following mutations in genes associated with mitochondrial functions, such as ABCB7 in X-linked sideroblastic anemia with ataxia (XLSA/A) or the genes encoding frataxin in Friedreich"s ataxia (FRDA).	Iron	0-4	frataxin	Homo sapiens	351-359
20393584-8	2010	The treatment reduced the mitochondrial levels of labile iron pools (LIP) that were increased by frataxin deficiency.	Iron	57-61	frataxin	Homo sapiens	97-105
19640812-2	2010	The HFE gene encodes a protein that is intimately involved in intestinal iron absorption.	Iron	73-77	homeostatic iron regulator	Homo sapiens	4-7
19640812-3	2010	AIMS: The aim of this study was to determine the prevalence of the HFE gene mutation, its role in iron metabolism of Wilson"s disease patients and the interplay of therapy in copper and iron homeostasis.	Iron	98-102	homeostatic iron regulator	Homo sapiens	67-70
19640812-3	2010	AIMS: The aim of this study was to determine the prevalence of the HFE gene mutation, its role in iron metabolism of Wilson"s disease patients and the interplay of therapy in copper and iron homeostasis.	Iron	186-190	homeostatic iron regulator	Homo sapiens	67-70
19640812-6	2010	The HFE mutation was significantly associated with increased hepatic iron content (P<0.02) and transferrin saturation index (P<0.03).	Iron	69-73	homeostatic iron regulator	Homo sapiens	4-7
19640812-7	2010	After treatment period, iron indices were significantly decreased only in HFE gene wild-type.	Iron	24-28	homeostatic iron regulator	Homo sapiens	74-77
19640812-8	2010	CONCLUSIONS: The HFE gene mutations may be an addictional factor in iron overload in Wilson"s disease.	Iron	68-72	homeostatic iron regulator	Homo sapiens	17-20
19640812-9	2010	Our results showed that an adjustment of dosage of drugs could prevent further iron overload induced by overtreatment only in patients HFE wild-type.	Iron	79-83	homeostatic iron regulator	Homo sapiens	135-138
19931264-1	2010	BACKGROUND &amp; AIMS: Mutations in the hemochromatosis gene (HFE) (C282Y and H63D) lead to parenchymal iron accumulation, hemochromatosis, and liver damage.	Iron	104-108	homeostatic iron regulator	Homo sapiens	62-65
19931264-6	2010	Hepatocellular siderosis was more prevalent in patients with HFE mutations than in those without; approximately one third of patients with HFE mutations had parenchymal iron accumulation (range, 29.8%-35.7%, depending on HFE genotype).	Iron	169-173	homeostatic iron regulator	Homo sapiens	139-142
19931264-6	2010	Hepatocellular siderosis was more prevalent in patients with HFE mutations than in those without; approximately one third of patients with HFE mutations had parenchymal iron accumulation (range, 29.8%-35.7%, depending on HFE genotype).	Iron	169-173	homeostatic iron regulator	Homo sapiens	139-142
19931264-7	2010	Predominantly hepatocellular iron accumulation occurred in 52.7% of cases of patients with HFE mutations.	Iron	29-33	homeostatic iron regulator	Homo sapiens	91-94
19863534-5	2010	IDA and ACD/IDA, but not ACD, showed an association between GDF15 and soluble transferrin receptor, an indicator of iron requirement for erythropoiesis.	Iron	116-120	transferrin receptor	Homo sapiens	78-98
20179792-3	2010	The majority of patients with clinically significant iron overload are homozygous for the C282Y mutation of the HFE gene, however only a minority of C282Y homozygotes fully express the disease clinically.	Iron	53-57	homeostatic iron regulator	Homo sapiens	112-115
19923256-9	2010	Although the CYP2J2 active site can accommodate large substrates, it may be more narrow than CYP3A4, limiting metabolism to moieties that can extend closer toward the active heme iron.	Iron	179-183	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	13-19
20101754-4	2010	Alcohol intake, smoking habits, and iron removed to depletion were similar in patients with and without HFE-related iron overload.	Iron	116-120	homeostatic iron regulator	Homo sapiens	104-107
20101754-5	2010	Hepatitis B virus (4% and 9%; P = 0.04) and hepatitis C virus (6% and 19%; P = 0.002) infections were more frequent in patients with non-HFE-related iron overload.	Iron	149-153	homeostatic iron regulator	Homo sapiens	137-140
20101754-11	2010	CONCLUSION: Patients with HFE and non-HFE-related iron overload have comparable iron overload and similar clinical history.	Iron	50-54	homeostatic iron regulator	Homo sapiens	38-41
20101754-11	2010	CONCLUSION: Patients with HFE and non-HFE-related iron overload have comparable iron overload and similar clinical history.	Iron	80-84	homeostatic iron regulator	Homo sapiens	26-29
20101754-11	2010	CONCLUSION: Patients with HFE and non-HFE-related iron overload have comparable iron overload and similar clinical history.	Iron	80-84	homeostatic iron regulator	Homo sapiens	38-41
20052970-0	2010	Cysteine oxidation enhanced by iron in tristetraprolin, a zinc finger peptide.	Iron	31-35	ZFP36 ring finger protein	Homo sapiens	39-54
20098432-2	2010	These complications are caused by labile plasma iron, which is taken up by parenchymal cells in a dysregulated manner; in contrast, erythropoiesis depends on transferrin-bound iron uptake via the transferrin receptor.	Iron	176-180	transferrin receptor	Mus musculus	196-216
19744503-0	2010	Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake.	Iron	92-96	protein phosphatase 1, regulatory subunit 3A	Mus musculus	0-3
19744503-2	2010	Our previous study observed the protective effect of Rg1 on iron accumulation in the substantia nigra (SN) in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-treated Parkinson"s disease (PD) mice.	Iron	60-64	protein phosphatase 1, regulatory subunit 3A	Mus musculus	53-56
19744503-9	2010	Furthermore, we also showed Rg1 could decrease DMT1-mediated ferrous iron uptake and iron-induced cell damage by inhibiting the up-regulation of DMT1-IRE.	Iron	69-73	protein phosphatase 1, regulatory subunit 3A	Mus musculus	28-31
19744503-9	2010	Furthermore, we also showed Rg1 could decrease DMT1-mediated ferrous iron uptake and iron-induced cell damage by inhibiting the up-regulation of DMT1-IRE.	Iron	85-89	protein phosphatase 1, regulatory subunit 3A	Mus musculus	28-31
19744503-10	2010	These results indicate that Rg1 protected the MPP+-treated MES23.5 cells via attenuating DMT1-IRE up-regulation likely through inhibition of ROS-NF-kappaB pathway; Attenuation of DMT1-IRE expression decreased the iron influx and iron-induced oxidative stress.	Iron	213-217	protein phosphatase 1, regulatory subunit 3A	Mus musculus	28-31
19744503-10	2010	These results indicate that Rg1 protected the MPP+-treated MES23.5 cells via attenuating DMT1-IRE up-regulation likely through inhibition of ROS-NF-kappaB pathway; Attenuation of DMT1-IRE expression decreased the iron influx and iron-induced oxidative stress.	Iron	229-233	protein phosphatase 1, regulatory subunit 3A	Mus musculus	28-31
20164445-3	2010	Here, we report that the mitochondrial ABC transporter ATM3, previously implicated in the maturation of extramitochondrial iron-sulfur proteins, has a crucial role also in Moco biosynthesis.	Iron	123-127	Thioredoxin superfamily protein	Arabidopsis thaliana	55-59
20164445-4	2010	In ATM3 insertion mutants of Arabidopsis thaliana, the activities of nitrate reductase and sulfite oxidase were decreased to approximately 50%, whereas the activities of xanthine dehydrogenase and aldehyde oxidase, whose activities also depend on iron-sulfur clusters, were virtually undetectable.	Iron	247-251	Thioredoxin superfamily protein	Arabidopsis thaliana	3-7
20137162-2	2010	Iron uptake of the vast majority cells, including tumor cells, is primarily mediated by transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	88-108
20137162-2	2010	Iron uptake of the vast majority cells, including tumor cells, is primarily mediated by transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	110-113
18718812-1	2009	Meningococcal FetA is an iron-regulated, immunogenic outer membrane protein and vaccine component.	Iron	25-29	ATPase phospholipid transporting 8B5, pseudogene	Homo sapiens	14-18
19019832-9	2009	Our finding is not only the first demonstration of regulation of Cp by ROS by a novel post-transcriptional mechanism but also provides a mechanism of iron deposition in neurodegenerative diseases.	Iron	150-154	ceruloplasmin	Bos taurus	65-67
18927074-5	2009	Here we show that clioquinol inhibits the activity of mammalian CLK-1 in cultured cells, an inhibition that can be blocked by iron or cobalt cations, suggesting that chelation is involved in the mechanism of action of clioquinol on CLK-1.	Iron	126-130	CDC like kinase 1	Homo sapiens	64-69
22386999-1	2012	A new electrochemical permeable reactive barrier (Electro-PRB) system for removal of hexavalent chromium [Cr(VI)] using Fe(0) meshes was developed.	Iron	120-125	RB transcriptional corepressor 1	Homo sapiens	58-61
19414144-2	2009	Since the discovery of the haemochromatosis gene (HFE) in 1996, several novel gene defects have been detected, explaining the mechanism and diversity of iron overload diseases.	Iron	153-157	homeostatic iron regulator	Homo sapiens	50-53
19019709-6	2009	The ensemble of these observations suggests that in cancer cell lines TfR2 expression can be modulated through stimuli similar to those known to act on TfR1 and these findings may have important implications for our understanding of the role of TfR2 in the regulation of iron homeostasis.	Iron	271-275	transferrin receptor	Homo sapiens	152-156
19843542-2	2010	Sequence comparisons, employing structural insights, suggest that PHF8 contains the double stranded beta-helix fold and ferrous iron binding residues that are present in 2-oxoglutarate-dependent oxygenases.	Iron	128-132	PHD finger protein 8	Homo sapiens	66-70
22386999-2	2012	Electro-PRB was found to be effective for electrochemical depassivation of Fe(0) to remove Cr(VI) during treatment.	Iron	75-80	RB transcriptional corepressor 1	Homo sapiens	8-11
20371435-0	2010	Coexistence of HFE and rare UGT1A1 genes mutations in patients with iron overload related liver injury.	Iron	68-72	homeostatic iron regulator	Homo sapiens	15-18
19291720-6	2009	L(3) was also used as a ligand in new thermochromic coordination complexes [M(CH(3)OH)(2)(L(3))(2)(NCX)(2)], in which M(II) = Fe, Co, Ni, Cu or Mn and X = S or Se (1-6), which allowed the fine-tuning of the electron density in the photochromic moiety.	Iron	126-128	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	0-4
22386999-7	2012	Scanning electron microscope analysis of acid-washed, electrochemically depassivated, and passivated Fe(0) confirmed the efficiency of Elecro-PRB in the recovery Fe(0) reactivity.	Iron	101-106	RB transcriptional corepressor 1	Homo sapiens	142-145
22386999-7	2012	Scanning electron microscope analysis of acid-washed, electrochemically depassivated, and passivated Fe(0) confirmed the efficiency of Elecro-PRB in the recovery Fe(0) reactivity.	Iron	162-167	RB transcriptional corepressor 1	Homo sapiens	142-145
20047515-8	2010	Ferrous sperm whale myoglobin (Mb), which has no reactive thiol, elicited a significant contraction (55.1+/-13.2%) while metMb did not (-0.8+/-3.2%), suggesting the relative importance of heme-iron ligand and oxidation state in Hb vasoactivity.	Iron	193-197	myoglobin	Physeter catodon	20-29
22386999-8	2012	The results indicate that the Electro-PRB system proposed here is capable of recovering the reactivity of Fe(0), which may prolong the operation of Cr(VI) removal processes.	Iron	106-111	RB transcriptional corepressor 1	Homo sapiens	38-41
21947086-1	2012	HFE-hemochromatosis is a common autosomal recessive disease caused by HFE gene mutations and characterized as iron overload and failure of different organs.	Iron	110-114	homeostatic iron regulator	Homo sapiens	0-3
20002197-3	2010	Immunomicroscopy with cytochrome-specific antibodies revealed that MtrC co-localizes with iron solids on the cell surface while OmcA exhibits a more diffuse distribution over the cell surface.	Iron	90-94	OmcA/MtrC family decaheme c-type cytochrome	Shewanella oneidensis MR-1	67-71
19759876-2	2009	Other mutations have been described in the HFE gene as well as in genes involved in iron metabolism, such as transferrin receptor 2 (TfR2) and ferroportin 1 (SCL40A1).	Iron	84-88	homeostatic iron regulator	Homo sapiens	43-46
20182641-1	2010	We have reported three Fe-deficiency-responsive elements (FEREs), FOX1, ATX1, and FEA1, all of which are positive regulatory elements in response to iron deficiency in Chlamydomonas reinhardtii.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	66-70
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	aconitase 1	Rattus norvegicus	166-191
21174978-7	2010	BET, NH3-TPD and NOx-TPD results showed that the specific surface area and NH3 and NOx adsorption capacity of the catalysts increased with iron doping.	Iron	139-143	delta/notch like EGF repeat containing	Homo sapiens	0-3
19822954-3	2009	Three allelic variants of HFE gene have been correlated with hereditary hemochromatosis: C282Y is significantly associated with hereditary hemochromatosis in populations of Celtic origin, H63D and S65C are associated with milder form of iron overload.	Iron	237-241	homeostatic iron regulator	Homo sapiens	26-29
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	aconitase 1	Rattus norvegicus	193-197
22198321-3	2012	There is also evidence showing that a series of genes with important functions in iron metabolism, including transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1), are regulated by HIF-1alpha in response to hypoxia in extra-neural organs or cells.	Iron	82-86	transferrin receptor	Homo sapiens	109-129
19433916-0	2009	Mutant HFE genotype leads to significant iron overload in patients with liver diseases from western Romania.	Iron	41-45	homeostatic iron regulator	Homo sapiens	7-10
19433916-1	2009	The present study aimed at assessing the frequency of HFE mutations (C282Y, H63D and S65C) in western Romanian patients with liver disease of diverse aetiologies suspected of iron overload.	Iron	175-179	homeostatic iron regulator	Homo sapiens	54-57
21179971-1	2010	Fe-doped TiO2 coated on activated carbon (Fe-TiO2/AC, FTA) composites were prepared by an improved sol-gel method and characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, inductively coupled plasma mass spectrometry and BET surface area analysis.	Iron	0-2	delta/notch like EGF repeat containing	Homo sapiens	270-273
22198321-3	2012	There is also evidence showing that a series of genes with important functions in iron metabolism, including transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1), are regulated by HIF-1alpha in response to hypoxia in extra-neural organs or cells.	Iron	82-86	transferrin receptor	Homo sapiens	131-135
22198321-5	2012	We herein demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (ferroportin1) proteins, and thus increase tansferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release in astrocytes.	Iron	129-133	transferrin receptor	Homo sapiens	142-146
20099195-8	2010	Conversely, lower beta -glucuronidase activity was significantly associated with higher intakes of calcium, iron, and magnesium.	Iron	108-112	glucuronidase beta	Homo sapiens	18-37
22265917-0	2012	Increased risk of death from iron overload among 422 treated probands with HFE hemochromatosis and serum levels of ferritin greater than 1000 mug/L at diagnosis.	Iron	29-33	homeostatic iron regulator	Homo sapiens	75-78
20199637-6	2010	CF patients possessing HFE mutations had significantly better iron stores than non-carriers (P &lt; 0.05).	Iron	62-66	homeostatic iron regulator	Homo sapiens	23-26
20199637-10	2010	CONCLUSIONS: HFE gene mutations modify disease severity in CF, through probable effects on iron homeostasis.	Iron	91-95	homeostatic iron regulator	Homo sapiens	13-16
19858116-0	2009	Wheat (Triticum aestivum) NAM proteins regulate the translocation of iron, zinc, and nitrogen compounds from vegetative tissues to grain.	Iron	69-73	NAC domain-containing protein 20	Triticum aestivum	26-29
19858116-2	2009	An RNAi line with reduced expression of NAM genes has lower grain protein, iron (Fe), and zinc (Zn) concentrations.	Iron	75-79	NAC domain-containing protein 20	Triticum aestivum	40-43
19858116-2	2009	An RNAi line with reduced expression of NAM genes has lower grain protein, iron (Fe), and zinc (Zn) concentrations.	Iron	81-83	NAC domain-containing protein 20	Triticum aestivum	40-43
22019713-1	2012	Transferrin receptor-1 (TfR1) is a cell membrane-associated glycoprotein responsible for incorporation of the iron bound to transferrin through an endocytotic process from the circulating blood.	Iron	110-114	transferrin receptor	Mus musculus	0-22
19747625-6	2009	In the cerebral cortex and caudate putamen of 80-week-old CP(-/-) mice, the expression of Heph increased significantly whilst iron levels remain normal [Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.	Iron	233-237	hephaestin	Mus musculus	90-94
18663607-5	2009	TcNRAMP3 was able to rescue growth of an iron uptake fet3fet4 mutant yeast strain, suggesting a possible role in iron transport.	Iron	41-45	ferroxidase FET3	Saccharomyces cerevisiae S288C	53-61
18663607-5	2009	TcNRAMP3 was able to rescue growth of an iron uptake fet3fet4 mutant yeast strain, suggesting a possible role in iron transport.	Iron	113-117	ferroxidase FET3	Saccharomyces cerevisiae S288C	53-61
20560808-12	2010	This finding is consistent with the possibility that, in OA patients with HFE gene mutations, localized iron overload may contribute either directly or indirectly to osteochondral damage, possibly in a similar way to that which occurs in the arthropathy that complicates HH.	Iron	104-108	homeostatic iron regulator	Homo sapiens	74-77
22019713-1	2012	Transferrin receptor-1 (TfR1) is a cell membrane-associated glycoprotein responsible for incorporation of the iron bound to transferrin through an endocytotic process from the circulating blood.	Iron	110-114	transferrin receptor	Mus musculus	24-28
22019713-4	2012	Marked mRNA expression was seen for various iron-related genes such as TfR1 in cultured mouse neocortical neurons, while TfR1 mRNA levels were more than doubled during culture from 3 to 6days.	Iron	44-48	transferrin receptor	Mus musculus	71-75
19183107-10	2009	Furthermore, up-regulation of TfR expression in leukemia cells by iron chelator deferoxamine resulted in a further increase in antisense effect (up to 79% Bcl-2 reduction in K562 at the mRNA level) and in caspase-dependent apoptosis (by approximately 3-fold) by Tf-LN.	Iron	66-70	transferrin receptor	Homo sapiens	30-33
22019713-7	2012	Overexpression of TfR1 significantly decreased the length of neurite elongated, however, while significant promotion was invariably seen in the neurite elongation in Neuro2A cells transfected with TfR1 siRNA as well as in Neuro2A cells cultured with an iron chelator.	Iron	253-257	transferrin receptor	Mus musculus	18-22
22169361-0	2012	Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia.	Iron	10-14	coagulation factor VIII	Homo sapiens	68-91
19000728-0	2009	Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins.	Iron	19-23	protein phosphatase 1, regulatory subunit 3A	Mus musculus	0-3
19000728-0	2009	Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins.	Iron	81-85	protein phosphatase 1, regulatory subunit 3A	Mus musculus	0-3
19000728-3	2009	Whether Rg1 could reduce nigral iron levels to protect the dopaminergic neurons?	Iron	32-36	protein phosphatase 1, regulatory subunit 3A	Mus musculus	8-11
22169361-10	2012	CONCLUSIONS: In this population, low serum iron levels attributed to inadequate replacement of haemorrhagic iron losses are associated with elevated plasma levels of coagulation factor VIII and venous thromboembolic risk.	Iron	43-47	coagulation factor VIII	Homo sapiens	166-189
22499121-1	2012	The hemochromatosis (HFE) gene encodes the HFE protein that regulates iron absorption.	Iron	70-74	homeostatic iron regulator	Homo sapiens	21-24
19210716-3	2009	IRT3 genes from both A. halleri and A. thaliana functionally complemented the Zn uptake mutant Spzrt1 in Schizosaccharomyces pombe; and Zn uptake double mutant zrt1zrt2, Fe-uptake mutant fet3fet4 and conferred Zn and Fe uptake activity in Saccharomyces cerevisiae.	Iron	170-172	iron regulated transporter 3	Arabidopsis thaliana	0-4
22499121-1	2012	The hemochromatosis (HFE) gene encodes the HFE protein that regulates iron absorption.	Iron	70-74	homeostatic iron regulator	Homo sapiens	43-46
19210716-3	2009	IRT3 genes from both A. halleri and A. thaliana functionally complemented the Zn uptake mutant Spzrt1 in Schizosaccharomyces pombe; and Zn uptake double mutant zrt1zrt2, Fe-uptake mutant fet3fet4 and conferred Zn and Fe uptake activity in Saccharomyces cerevisiae.	Iron	217-219	iron regulated transporter 3	Arabidopsis thaliana	0-4
22499121-2	2012	HFE mutations lead to the hemochromatosis disease of excessive iron absorption.	Iron	63-67	homeostatic iron regulator	Homo sapiens	0-3
22375032-3	2012	Here, we show that ABCB8 is involved in mitochondrial iron export and is essential for baseline cardiac function.	Iron	54-58	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	19-24
18849539-10	2008	Enhanced TfR-mediated influx of Fe from the blood and ferroportin-mediated expelling Fe toward the CSF may compromise DMT1-mediated efflux, leading to an increased Fe concentration in the CSF as seen in Mn-exposed animals.	Iron	32-34	transferrin receptor	Rattus norvegicus	9-12
22375032-6	2012	Down-regulation of ABCB8 in vitro resulted in decreased iron export from isolated mitochondria, whereas its overexpression had the opposite effect.	Iron	56-60	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	19-24
22375032-7	2012	Furthermore, ABCB8 is needed for the maturation of the cytosolic Fe/S proteins, as its deletion in vitro and in vivo led to decreased activity of cytosolic, but not mitochondrial, iron-sulfur-containing enzymes.	Iron	180-184	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	13-18
22375032-8	2012	These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins.	Iron	105-109	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	28-33
22033148-2	2012	Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor.	Iron	0-4	hemopexin	Homo sapiens	110-119
18848943-0	2008	The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis.	Iron	29-33	homeostatic iron regulator	Homo sapiens	46-49
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	128-132	transferrin receptor	Homo sapiens	141-145
19093974-0	2008	Iron deficiency-induced increase of root branching contributes to the enhanced root ferric chelate reductase activity.	Iron	0-4	ferric-chelate reductase	Solanum lycopersicum	84-108
22309771-7	2012	Taken together, these results suggest that the unusual [2Fe-2S]-bridging Grx-BolA interaction is conserved in higher eukaryotes and may play a role in signaling cellular iron status in humans.	Iron	170-174	glutaredoxin	Homo sapiens	73-76
19093974-3	2008	In the present research, we demonstrated that the lateral root development of red clover (Trifolium pretense L.) was significantly enhanced by Fe deficient treatment, and the total lateral root number correlated well with the Fe deficiency-induced ferric chelate reductase (FCR) activity.	Iron	226-228	ferric-chelate reductase	Solanum lycopersicum	248-272
19093974-3	2008	In the present research, we demonstrated that the lateral root development of red clover (Trifolium pretense L.) was significantly enhanced by Fe deficient treatment, and the total lateral root number correlated well with the Fe deficiency-induced ferric chelate reductase (FCR) activity.	Iron	226-228	ferric-chelate reductase	Solanum lycopersicum	274-277
22228627-6	2012	In univariate analyses, hepcidin, ferritin, C-reactive protein, and soluble transferrin receptor (sTfR) strongly predicted incorporation of (57)Fe given on day 1, while hepcidin, ferritin, and sTfR/log ferritin correlated with (58)Fe incorporation.	Iron	144-146	transferrin receptor	Homo sapiens	76-96
19014383-10	2008	Tim-2 expression on CG4 cells is responsive to iron; decreasing with iron loading and increasing with iron chelation.	Iron	47-51	T-cell immunoglobulin and mucin domain containing 2	Rattus norvegicus	0-5
19014383-10	2008	Tim-2 expression on CG4 cells is responsive to iron; decreasing with iron loading and increasing with iron chelation.	Iron	69-73	T-cell immunoglobulin and mucin domain containing 2	Rattus norvegicus	0-5
19014383-10	2008	Tim-2 expression on CG4 cells is responsive to iron; decreasing with iron loading and increasing with iron chelation.	Iron	69-73	T-cell immunoglobulin and mucin domain containing 2	Rattus norvegicus	0-5
19014383-11	2008	Taken together, these data provide compelling evidence that Tim-2 is the H-ferritin receptor on oligodendrocytes suggesting it is the primary mechanism for iron acquisition by these cells.	Iron	156-160	T-cell immunoglobulin and mucin domain containing 2	Rattus norvegicus	60-65
22178061-8	2012	In macrophages, increased expression levels and co-localization of ferroportin and GPI-ceruloplasmin in cell surface lipid rafts were observed after iron treatment.	Iron	149-153	glucose-6-phosphate isomerase	Homo sapiens	83-86
19022969-2	2008	The soluble transferrin receptor (sTfR):ferritin ratio has been suggested to be a better index than ferritin to measure body iron stores.	Iron	125-129	transferrin receptor	Homo sapiens	12-32
22178061-12	2012	In macrophages, GPI-ceruloplasmin and ferroportin likely interact in lipid rafts to export iron from cells.	Iron	91-95	glucose-6-phosphate isomerase	Homo sapiens	16-19
19011085-5	2008	Using the PD animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication in mice, we showed that DMT1 expression increases in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress, and dopaminergic cell loss.	Iron	214-218	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	118-122
22157760-0	2012	Iron-responsive transcription factor Aft1 interacts with kinetochore protein Iml3 and promotes pericentromeric cohesin.	Iron	0-4	Iml3p	Saccharomyces cerevisiae S288C	77-81
19011085-6	2008	In addition, we report that a mutation in DMT1 that impairs iron transport protects rodents against parkinsonism-inducing neurotoxins MPTP and 6-hydroxydopamine.	Iron	60-64	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	42-46
19011085-7	2008	This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD.	Iron	48-52	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	40-44
22068601-7	2012	Expression of the neuron-specific synaptogenesis marker, disc-large homolog 4 (PSD95), increased more rapidly than the glia-specific myelination marker, myelin basic protein, following iron treatment, suggesting a more robust response to iron therapy in IGF-I-dependent neurons than IGF-II-dependent glia.	Iron	185-189	discs large MAGUK scaffold protein 4	Rattus norvegicus	79-84
18776082-0	2008	Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.	Iron	58-62	WW domain containing E3 ubiquitin protein ligase 2	Mus musculus	131-135
18776082-8	2008	Consistent with these observations, Ndfip1(-/-) mice show increased DMT1 activity and a concomitant increase in hepatic iron deposition, indicating an essential function of Ndfip1 in iron homeostasis.	Iron	120-124	Nedd4 family interacting protein 1	Mus musculus	36-42
18776082-8	2008	Consistent with these observations, Ndfip1(-/-) mice show increased DMT1 activity and a concomitant increase in hepatic iron deposition, indicating an essential function of Ndfip1 in iron homeostasis.	Iron	183-187	Nedd4 family interacting protein 1	Mus musculus	36-42
22101841-4	2012	M. tuberculosis has two iron storage proteins, namely BfrA (Rv1876; a bacterioferritin) and BfrB (Rv3841; a ferritin-like protein).	Iron	24-28	bacterioferritin BfrA	Mycobacterium tuberculosis H37Rv	54-58
18776082-8	2008	Consistent with these observations, Ndfip1(-/-) mice show increased DMT1 activity and a concomitant increase in hepatic iron deposition, indicating an essential function of Ndfip1 in iron homeostasis.	Iron	183-187	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	68-72
18776082-8	2008	Consistent with these observations, Ndfip1(-/-) mice show increased DMT1 activity and a concomitant increase in hepatic iron deposition, indicating an essential function of Ndfip1 in iron homeostasis.	Iron	183-187	Nedd4 family interacting protein 1	Mus musculus	173-179
18776082-9	2008	This novel mechanism of regulating iron homeostasis suggests that Ndfips and WWP2 may contribute to diseases involving aberrant iron transport.	Iron	35-39	WW domain containing E3 ubiquitin protein ligase 2	Mus musculus	77-81
18776082-9	2008	This novel mechanism of regulating iron homeostasis suggests that Ndfips and WWP2 may contribute to diseases involving aberrant iron transport.	Iron	128-132	WW domain containing E3 ubiquitin protein ligase 2	Mus musculus	77-81
22101841-6	2012	In this study, we have disrupted bfrA and bfrB of M. tuberculosis and demonstrated that these genes are crucial for the storage and supply of iron for the growth of bacteria and to withstand oxidative stress in vitro.	Iron	142-146	bacterioferritin BfrA	Mycobacterium tuberculosis H37Rv	33-37
18725397-2	2008	Although the exact function of frataxin is still a matter of debate, it is widely accepted that frataxin is a mitochondrial iron chaperone involved in iron-sulfur cluster and heme biosynthesis.	Iron	124-128	frataxin	Homo sapiens	96-104
21833493-7	2012	In all species, the Fe(2+)-induced increase in 3HAO activity was dose-dependently attenuated by the addition of ferritin, the main iron storage protein in the brain.	Iron	131-135	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	47-51
18725397-2	2008	Although the exact function of frataxin is still a matter of debate, it is widely accepted that frataxin is a mitochondrial iron chaperone involved in iron-sulfur cluster and heme biosynthesis.	Iron	151-155	frataxin	Homo sapiens	96-104
18821709-2	2008	Under iron-deficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron.	Iron	6-10	transferrin receptor	Homo sapiens	79-82
18821709-2	2008	Under iron-deficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron.	Iron	167-171	transferrin receptor	Homo sapiens	79-82
22184655-9	2012	Moreover, co-overexpression of FIT with AtbHLH38 or AtbHLH39 also enhanced the expression of NICOTIANAMINE SYNTHETASE1 (NAS1) and NAS2, resulting in the accumulation of nicotiananamine, a crucial chelator for Fe transportation and homeostasis.	Iron	209-211	nicotianamine synthase 1	Arabidopsis thaliana	120-124
18694996-0	2008	Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.	Iron	25-29	transferrin receptor	Mus musculus	70-75
23560311-2	2012	FRDA is caused by a GAA expansion in intron one of the FXN gene, leading to reduced levels of the encoded protein frataxin, which is thought to regulate cellular iron homeostasis.	Iron	162-166	frataxin	Homo sapiens	0-4
23560311-2	2012	FRDA is caused by a GAA expansion in intron one of the FXN gene, leading to reduced levels of the encoded protein frataxin, which is thought to regulate cellular iron homeostasis.	Iron	162-166	frataxin	Homo sapiens	55-58
18760346-0	2008	The manganese superoxide dismutase Ala16Val dimorphism modulates iron accumulation in human hepatoma cells.	Iron	65-69	superoxide dismutase 2	Homo sapiens	4-34
18760346-2	2008	In alcoholic cirrhotic patients, the Ala-MnSOD allele is associated with hepatic iron accumulation and an increased risk of hepatocellular carcinoma.	Iron	81-85	superoxide dismutase 2	Homo sapiens	41-46
18760346-3	2008	The Ala-MnSOD variant could modulate the expression of proteins involved in iron storage (cytosolic ferritin), uptake (transferrin receptors, TfR-1 and-2), extrusion (hepcidin), and intracellular distribution (frataxin) to trigger hepatic iron accumulation.	Iron	76-80	superoxide dismutase 2	Homo sapiens	8-13
18760346-3	2008	The Ala-MnSOD variant could modulate the expression of proteins involved in iron storage (cytosolic ferritin), uptake (transferrin receptors, TfR-1 and-2), extrusion (hepcidin), and intracellular distribution (frataxin) to trigger hepatic iron accumulation.	Iron	239-243	superoxide dismutase 2	Homo sapiens	8-13
18760346-5	2008	In our cohort, this hepatic iron score increased with the number of Ala-MnSOD alleles.	Iron	28-32	superoxide dismutase 2	Homo sapiens	72-77
18760346-8	2008	Additionally, iron supplementation decreased transfected MnSOD proteins and activities.	Iron	14-18	superoxide dismutase 2	Homo sapiens	57-62
20853605-8	2010	HFE gene mutation carriage accelerates iron accumulation and is an additional risk factor for siderosis.	Iron	39-43	homeostatic iron regulator	Homo sapiens	0-3
19711434-1	2009	BACKGROUND: Our original studies reported an association between the iron-metabolism gene HFE and risk of childhood acute lymphoblastic leukemia (ALL), and a birth weight association in ALL.	Iron	69-73	homeostatic iron regulator	Homo sapiens	90-93
18760346-9	2008	Ala-MnSOD transfection increased the mRNAs and proteins of ferritin, hepcidin, and TfR2, decreased the expression of frataxin, and caused cellular iron accumulation.	Iron	147-151	superoxide dismutase 2	Homo sapiens	4-9
23226624-19	2012	In recipients of grafts with mutant HFE variants a "mixed chimerism" of HFE in body tissues might be created with a change in the set point for iron regulation.	Iron	144-148	homeostatic iron regulator	Homo sapiens	36-39
18760346-11	2008	In conclusion, the Ala-MnSOD variant favors hepatic iron accumulation by modulating the expression of proteins involved in iron homeostasis.	Iron	52-56	superoxide dismutase 2	Homo sapiens	23-28
18760346-11	2008	In conclusion, the Ala-MnSOD variant favors hepatic iron accumulation by modulating the expression of proteins involved in iron homeostasis.	Iron	123-127	superoxide dismutase 2	Homo sapiens	23-28
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	ferroxidase FET3	Saccharomyces cerevisiae S288C	84-88
19943689-6	2009	The work also shows that the original high-temperature method for the preparation of the [(eta(6)-arene)(2)Fe](2+) dications fails for mesitylene and durene compounds, which was overcome by a reliable room-temperature modification.	Iron	107-109	endothelin receptor type A	Homo sapiens	91-94
19828835-8	2009	TFR1 knockdown reduced iron uptake by 80% while TFR2 knockdown did not affect uptake.	Iron	23-27	transferrin receptor	Homo sapiens	0-4
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	ferroxidase FET3	Saccharomyces cerevisiae S288C	187-191
23226624-19	2012	In recipients of grafts with mutant HFE variants a "mixed chimerism" of HFE in body tissues might be created with a change in the set point for iron regulation.	Iron	144-148	homeostatic iron regulator	Homo sapiens	72-75
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	ferroxidase FET3	Saccharomyces cerevisiae S288C	187-191
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	ferroxidase FET3	Saccharomyces cerevisiae S288C	84-88
19838776-8	2009	The models rationally interpret the iron release from Fe(2)Tf-TfR upon acidification, dissociation of apoTf from TfR at slightly alkaline pH, and metal specific recognition of TfR.	Iron	36-40	transferrin receptor	Homo sapiens	62-65
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	ferroxidase FET3	Saccharomyces cerevisiae S288C	187-191
19838776-8	2009	The models rationally interpret the iron release from Fe(2)Tf-TfR upon acidification, dissociation of apoTf from TfR at slightly alkaline pH, and metal specific recognition of TfR.	Iron	36-40	transferrin receptor	Homo sapiens	113-116
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	ferroxidase FET3	Saccharomyces cerevisiae S288C	187-191
19838776-8	2009	The models rationally interpret the iron release from Fe(2)Tf-TfR upon acidification, dissociation of apoTf from TfR at slightly alkaline pH, and metal specific recognition of TfR.	Iron	36-40	transferrin receptor	Homo sapiens	113-116
23092063-6	2012	At level of a cell IRE/IRP (iron responsive elements/iron responsive proteins) system allows tight regulation of iron assimilation that prevents an excess of free intracellular iron which could lead to oxidative stress and damage of DNA, proteins and lipid membranes by ROS (reactive oxygen species).	Iron	28-32	Wnt family member 2	Homo sapiens	23-26
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	ferroxidase FET3	Saccharomyces cerevisiae S288C	84-88
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	ferroxidase FET3	Saccharomyces cerevisiae S288C	187-191
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	ferroxidase FET3	Saccharomyces cerevisiae S288C	187-191
18768754-3	2008	We report that iron-induced endocytosis of Fet3-Ftr1 is independent of Fet3-Ftr1 ubiquitylation, and after endocytosis, degradation of Fet3-Ftr1 is mediated by the multivesicular body (MVB) sorting pathway.	Iron	15-19	ferroxidase FET3	Saccharomyces cerevisiae S288C	43-47
23092063-6	2012	At level of a cell IRE/IRP (iron responsive elements/iron responsive proteins) system allows tight regulation of iron assimilation that prevents an excess of free intracellular iron which could lead to oxidative stress and damage of DNA, proteins and lipid membranes by ROS (reactive oxygen species).	Iron	53-57	Wnt family member 2	Homo sapiens	23-26
23092063-6	2012	At level of a cell IRE/IRP (iron responsive elements/iron responsive proteins) system allows tight regulation of iron assimilation that prevents an excess of free intracellular iron which could lead to oxidative stress and damage of DNA, proteins and lipid membranes by ROS (reactive oxygen species).	Iron	53-57	Wnt family member 2	Homo sapiens	23-26
23092063-6	2012	At level of a cell IRE/IRP (iron responsive elements/iron responsive proteins) system allows tight regulation of iron assimilation that prevents an excess of free intracellular iron which could lead to oxidative stress and damage of DNA, proteins and lipid membranes by ROS (reactive oxygen species).	Iron	53-57	Wnt family member 2	Homo sapiens	23-26
23092063-7	2012	At the same time IRE/IRP system provides sufficient iron in order to meet the metabolic needs.	Iron	52-56	Wnt family member 2	Homo sapiens	21-24
23115478-6	2012	Visual analytics integration of gene information sources helped identify RAC1, a GTP binding protein, and TFRC, an iron uptake protein as prioritized arsenic-perturbed protein targets for biological processes leading to skin hyperpigmentation.	Iron	115-119	transferrin receptor	Homo sapiens	106-110
23115478-9	2012	TFRC is a key determinant of the amount and location of iron in the epidermis.	Iron	56-60	transferrin receptor	Homo sapiens	0-4
23115478-10	2012	Aberrant TFRC expression could impair cutaneous iron metabolism leading to abnormal pigmentation seen in some humans exposed to arsenicals.	Iron	48-52	transferrin receptor	Homo sapiens	9-13
20817350-2	2012	In the Epistasis Project, with 1757 cases of AD and 6295 controls, we studied 4 variants in 2 genes of iron metabolism: hemochromatosis (HFE) C282Y and H63D, and transferrin (TF) C2 and -2G/A.	Iron	103-107	homeostatic iron regulator	Homo sapiens	137-140
20817350-7	2012	The interaction between HFE 282Y and TF C2 has now been replicated twice, in altogether 2313 cases of AD and 7065 controls, and has also been associated with increased iron load.	Iron	168-172	homeostatic iron regulator	Homo sapiens	24-27
22269801-6	2012	Furthermore, we demonstrated that the iron regulatory protein (IRP)/iron response element system contributed to UPS impairment-mediated DA neuron injury.	Iron	38-42	Wnt family member 2	Homo sapiens	63-66
22984573-0	2012	Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway.	Iron	40-44	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	24-31
22984573-4	2012	Only the basic helix-loop-helix (bHLH) transcription factor FIT has been shown to control the expression of the root iron uptake machinery genes FRO2 and IRT1.	Iron	117-121	ferric reduction oxidase 2	Arabidopsis thaliana	145-149
22984573-5	2012	Here, we characterize the biological role of two other iron-regulated transcription factors, bHLH100 and bHLH101, in iron homeostasis.	Iron	55-59	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	105-112
22984573-5	2012	Here, we characterize the biological role of two other iron-regulated transcription factors, bHLH100 and bHLH101, in iron homeostasis.	Iron	117-121	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	105-112
22984573-8	2012	bHLH100 and bHLH101 play a crucial role in iron-deficiency responses, as attested by their severe growth defects and iron homeostasis related phenotypes on low-iron media.	Iron	43-47	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	12-19
22984573-8	2012	bHLH100 and bHLH101 play a crucial role in iron-deficiency responses, as attested by their severe growth defects and iron homeostasis related phenotypes on low-iron media.	Iron	117-121	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	12-19
22984573-9	2012	To gain further insight into the biological role of bHLH100 and bHLH101, we performed microarray analysis using the corresponding double mutant and showed that bHLH100 and bHLH101 likely regulate genes involved in the distribution of iron within the plant.	Iron	234-238	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	64-71
22984573-9	2012	To gain further insight into the biological role of bHLH100 and bHLH101, we performed microarray analysis using the corresponding double mutant and showed that bHLH100 and bHLH101 likely regulate genes involved in the distribution of iron within the plant.	Iron	234-238	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	172-179
22984573-10	2012	Altogether, this work establishes bHLH100 and bHLH101 as key regulators of iron-deficiency responses independent of the master regulator FIT and sheds light on new regulatory networks important for proper growth and development under low iron conditions.	Iron	75-79	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	46-53
22448249-11	2012	The aneurysmal vessel wall in both groups of ANG II treated mice contained more iron-positive macrophages than saline-treated mice.	Iron	80-84	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	45-48
22363738-0	2012	The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin.	Iron	20-24	radical S-adenosyl methionine domain containing 2	Homo sapiens	110-117
22363738-4	2012	The results show that Viperin is an alpha-beta protein containing iron-sulfur cluster at the center pocket.	Iron	66-70	radical S-adenosyl methionine domain containing 2	Homo sapiens	22-29
22253756-3	2012	Mitoferrin 1 and mitoferrin 2, two homologues proteins belonging to the mitochondrial solute carrier family, are required for iron delivery into mitochondria.	Iron	126-130	solute carrier family 25 member 37	Danio rerio	0-12
22253756-4	2012	Mitoferrin 1 is highly expressed in developing erythrocytes which consume a large amount of iron during hemoglobinization.	Iron	92-96	solute carrier family 25 member 37	Danio rerio	0-12
22253756-6	2012	Zebrafish with mitoferrin 1 mutation show profound hypochromic anaemia and erythroid maturation arrests, and yeast with defects in MRS3/4, the counterparts of mitoferrin 1/2, has low mitochondrial iron levels and grows poorly by iron depletion.	Iron	229-233	solute carrier family 25 member 37	Danio rerio	15-27
22253756-7	2012	Mitoferrin 1 expression is up-regulated in yeast and mouse models of Fiedreich"s ataxia disease and in human cell culture models of Parkinson disease, suggesting its involvement in the pathogenesis of diseases with mitochondrial iron accumulation.	Iron	229-233	solute carrier family 25 member 37	Danio rerio	0-12
21880518-8	2011	Even though the variation in porphyric response did not parallel the hepatic iron concentration, the results are compatible with the presence of a Cyp1a2-independent, iron-dependent pathway for the generation of uroporphomethene, the UROD inhibitor required for the expression of uroporphyria in mice and PCT in humans.	Iron	167-171	uroporphyrinogen decarboxylase	Mus musculus	234-238
21274654-8	2011	Since alterations in iron levels in the brain are causally linked to degenerative conditions such as Alzheimer"s disease, an improved understanding of the regulation of iron transport protein expression such as FPN1, DMT1, and CP could lead to novel strategies for treatments.	Iron	21-25	ceruloplasmin	Rattus norvegicus	227-229
21274654-8	2011	Since alterations in iron levels in the brain are causally linked to degenerative conditions such as Alzheimer"s disease, an improved understanding of the regulation of iron transport protein expression such as FPN1, DMT1, and CP could lead to novel strategies for treatments.	Iron	169-173	ceruloplasmin	Rattus norvegicus	227-229
21863062-1	2011	The mitochondrial protein frataxin (FXN) is known to be involved in mitochondrial iron homeostasis and iron-sulfur cluster biogenesis.	Iron	103-107	frataxin	Homo sapiens	36-39
19994473-6	2009	It prevents binding of the iron regulatory protein 1 (IRP1) to the 5alpha untranslated region of L-ferritin resulting in uncontrolled L-ferritin synthesis and high serum ferritin levels independent of the body iron stores.	Iron	27-31	aconitase 1	Homo sapiens	54-58
22194696-2	2011	Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown.	Iron	95-99	Transcription factor elt-2	Caenorhabditis elegans	61-66
22194696-2	2011	Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown.	Iron	185-189	Transcription factor elt-2	Caenorhabditis elegans	61-66
22058337-9	2011	In all cases of iron overload, the expression of FLVCR and PCFT was upregulated and that of BCRP was downregulated.	Iron	16-20	feline leukemia virus subgroup C cellular receptor 1	Mus musculus	49-54
19709084-4	2009	This novel variant was identified in a pedigree originating from Central Italy and, although an intra-familial phenotype heterogeneity was observed, it co-segregated with an iron overload picture similar to that of the HFE-related typical haemochromatosis.	Iron	174-178	homeostatic iron regulator	Homo sapiens	219-222
19729324-2	2009	Among these is a second transferrin receptor (TfR2) that seems to play a key role in the regulation of iron homeostasis.	Iron	103-107	transferrin receptor	Homo sapiens	24-44
18648087-7	2008	Intestinal expression of mRNAs for the Fe-transporters DMT1 and ferroportin was increased in FeDF mice, but not in other EMDF mice, causing an increase in hepatic Fe concentration.	Iron	39-41	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	55-59
22058337-9	2011	In all cases of iron overload, the expression of FLVCR and PCFT was upregulated and that of BCRP was downregulated.	Iron	16-20	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	92-96
21926174-1	2011	Fe-S clusters (ISCs) are versatile cofactors utilized by many mitochondrial, cytoplasmic, and nuclear enzymes.	Iron	0-4	NFS1 cysteine desulfurase	Homo sapiens	15-19
18723004-4	2008	Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15.	Iron	126-130	complement C1q A chain	Rattus norvegicus	88-92
19731237-2	2009	Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron.	Iron	194-198	superoxide dismutase 2	Homo sapiens	0-30
19731237-2	2009	Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron.	Iron	194-198	superoxide dismutase 2	Homo sapiens	32-37
19731237-9	2009	Carriage of one or two Ala-SOD2 allele(s) was associated with higher liver iron scores and higher risks of HCC and death.	Iron	75-79	superoxide dismutase 2	Homo sapiens	27-31
19731237-12	2009	CONCLUSION: The combination of the GG-MPO genotype (leading to high MPO expression) and at least one Ala-SOD2 allele (associated with high liver iron score) markedly increased the risks of HCC occurrence and death in patients with alcoholic cirrhosis.	Iron	145-149	superoxide dismutase 2	Homo sapiens	105-109
18655771-1	2008	Iron regulatory protein (IRP)-1 and IRP2 inhibit ferritin synthesis by binding to an iron responsive element in the 5"-untranslated region of its mRNA.	Iron	85-89	aconitase 1	Homo sapiens	0-31
21715309-0	2011	Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.	Iron	86-90	ras homolog gene family, member Ab	Danio rerio	13-17
21715309-7	2011	Disruption of the arhgef3 target, RhoA, also produced severe anemia, which was, again, corrected by iron injection.	Iron	100-104	ras homolog gene family, member Ab	Danio rerio	34-38
19271219-12	2009	In adjusted logistic regression analysis, the HFE genotype had the highest impact on iron status markers; high alcohol consumption was significantly associated with elevated transferrin saturation.	Iron	85-89	homeostatic iron regulator	Homo sapiens	46-49
18842790-0	2008	Iron metabolism in heterozygotes for hemoglobin E (HbE), alpha-thalassemia 1, or beta-thalassemia and in compound heterozygotes for HbE/beta-thalassemia.	Iron	0-4	hemoglobin subunit epsilon 1	Homo sapiens	37-49
21080099-5	2011	DM2 patients had higher iron deposits, total body iron, and heme oxygenase activity (a suggestion of high oxidative stress condition) than MS subjects and controls.	Iron	24-28	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	0-3
18842790-0	2008	Iron metabolism in heterozygotes for hemoglobin E (HbE), alpha-thalassemia 1, or beta-thalassemia and in compound heterozygotes for HbE/beta-thalassemia.	Iron	0-4	hemoglobin subunit epsilon 1	Homo sapiens	51-54
18653481-14	2008	Our findings clearly demonstrate that in hemolytic anemia, renal Prohepcidin acts in coordination with renal Ferroportin and DMT1, indicating the key involvement of kidney in iron homeostasis when iron demand is high.	Iron	175-179	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	125-129
18653481-14	2008	Our findings clearly demonstrate that in hemolytic anemia, renal Prohepcidin acts in coordination with renal Ferroportin and DMT1, indicating the key involvement of kidney in iron homeostasis when iron demand is high.	Iron	197-201	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	125-129
19393285-8	2009	We have observed several suggestive QTL related to ventral midbrain iron content, including one on chromosome 17 that contains btbd9, a gene that in humans has been associated with restless legs syndrome and serum ferritin.	Iron	68-72	BTB domain containing 9	Homo sapiens	127-132
19673882-1	2009	There is emerging evidence that there are genetic modifiers of iron indices for HFE gene mutation carriers at risk of hereditary hemochromatosis.	Iron	63-67	homeostatic iron regulator	Homo sapiens	80-83
18637800-2	2008	The most frequent form is X-linked sideroblastic anaemia, caused by mutations of delta-aminolevulinic acid synthase 2 (ALAS2), the enzyme that catalyses the first and regulatory step of haem synthesis in erythroid precursors and is post-transcriptionally controlled by the iron regulatory proteins.	Iron	273-277	5'-aminolevulinate synthase 2	Homo sapiens	81-117
18637800-2	2008	The most frequent form is X-linked sideroblastic anaemia, caused by mutations of delta-aminolevulinic acid synthase 2 (ALAS2), the enzyme that catalyses the first and regulatory step of haem synthesis in erythroid precursors and is post-transcriptionally controlled by the iron regulatory proteins.	Iron	273-277	5'-aminolevulinate synthase 2	Homo sapiens	119-124
21080099-5	2011	DM2 patients had higher iron deposits, total body iron, and heme oxygenase activity (a suggestion of high oxidative stress condition) than MS subjects and controls.	Iron	50-54	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	0-3
21080099-6	2011	In DM2, we found a positive association between serum iron and HO activity.	Iron	54-58	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	3-6
18722041-1	2008	OBJECTIVE: We investigated mechanisms involved in iron (Fe) transport by DMT1 (endosomal Fe(II) exporter, encoded by the Nramp2 gene) using wild-type Chinese hamster ovary (CHO) cells and Nramp2-transfected CHO cells, as well as reticulocytes from normal and mk/mk mice that have a defect in DMT1.	Iron	50-54	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	73-77
19808020-0	2009	MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.	Iron	80-84	microRNA 210	Homo sapiens	0-12
22308152-1	2011	BACKGROUND: The human HFE gene (a key component of iron homeostasis in humans) is involved in hereditary hemochromatosis, a common autosomal recessive genetic disorder that is characterized by excessive intestinal iron absorption and progressive iron overload.	Iron	51-55	homeostatic iron regulator	Homo sapiens	22-25
19808020-2	2009	Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxic cell type, we identify the iron-sulfur cluster assembly proteins (ISCU1/2) as direct targets for repression by the hypoxia-induced microRNA-210 (miR-210).	Iron	112-116	microRNA 210	Homo sapiens	216-228
19808020-2	2009	Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxic cell type, we identify the iron-sulfur cluster assembly proteins (ISCU1/2) as direct targets for repression by the hypoxia-induced microRNA-210 (miR-210).	Iron	112-116	microRNA 210	Homo sapiens	230-237
19808020-4	2009	Under in vivo conditions of upregulating miR-210 and repressing ISCU1/2, the integrity of iron-sulfur clusters is disrupted.	Iron	90-94	microRNA 210	Homo sapiens	41-48
18722041-1	2008	OBJECTIVE: We investigated mechanisms involved in iron (Fe) transport by DMT1 (endosomal Fe(II) exporter, encoded by the Nramp2 gene) using wild-type Chinese hamster ovary (CHO) cells and Nramp2-transfected CHO cells, as well as reticulocytes from normal and mk/mk mice that have a defect in DMT1.	Iron	56-58	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	73-77
18722041-5	2008	RESULTS: Hyperexpression of DMT1 in CHO cells greatly increases their capacity to acquire ferrous iron.	Iron	90-102	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	28-32
22308152-1	2011	BACKGROUND: The human HFE gene (a key component of iron homeostasis in humans) is involved in hereditary hemochromatosis, a common autosomal recessive genetic disorder that is characterized by excessive intestinal iron absorption and progressive iron overload.	Iron	214-218	homeostatic iron regulator	Homo sapiens	22-25
18603562-12	2008	CONCLUSIONS: The findings of this study suggest that the observed TMPRSS6 mutation leads to overproduction of hepcidin and, in turn, to defective iron absorption and utilization.	Iron	146-150	transmembrane serine protease 6	Mus musculus	66-73
19732172-3	2009	iron requirements in hemodialysis (HD) patients with HFE mutations.	Iron	0-4	homeostatic iron regulator	Homo sapiens	53-56
22308152-1	2011	BACKGROUND: The human HFE gene (a key component of iron homeostasis in humans) is involved in hereditary hemochromatosis, a common autosomal recessive genetic disorder that is characterized by excessive intestinal iron absorption and progressive iron overload.	Iron	214-218	homeostatic iron regulator	Homo sapiens	22-25
21771600-2	2011	FXN is important in mitochondrial iron efflux, sensitivity to oxidative stress, and cell death.	Iron	34-38	frataxin	Homo sapiens	0-3
19834550-2	2009	Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent), preventing bacterial iron acquisition.	Iron	30-34	lipocalin 2	Mus musculus	0-4
19834550-2	2009	Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent), preventing bacterial iron acquisition.	Iron	99-103	lipocalin 2	Mus musculus	0-4
19337173-0	2008	Exaggerated TSH response to TRH ("sub-biochemical" hypothyroidism) in prepubertal and adolescent thalassaemic patients with iron overload: prevalence and 20-year natural history.	Iron	124-128	thyrotropin releasing hormone	Homo sapiens	28-31
21870996-3	2011	We now show that internalization of TfR1 bound to these antibodies can lead to its sequestration and degradation, as well as reduced Tf uptake, and the induction of a transcriptional response consistent with iron deprivation, which is mediated in part by downstream targets of p53.	Iron	208-212	transferrin receptor	Homo sapiens	36-40
19834550-5	2009	Whereas the ability of Lcn2 to sequester iron is well described, the ability of Lcn2 to induce inflammation during infection is unknown.	Iron	41-45	lipocalin 2	Mus musculus	23-27
19834550-6	2009	To study each potential effect of Lcn2 on colonization, we exploited K. pneumoniae mutants that are predicted to be susceptible to Lcn2-mediated iron sequestration (iroA ybtS mutant) or inflammation (iroA mutant), or to not interact with Lcn2 (entB mutant).	Iron	145-149	lipocalin 2	Mus musculus	131-135
19834550-6	2009	To study each potential effect of Lcn2 on colonization, we exploited K. pneumoniae mutants that are predicted to be susceptible to Lcn2-mediated iron sequestration (iroA ybtS mutant) or inflammation (iroA mutant), or to not interact with Lcn2 (entB mutant).	Iron	145-149	lipocalin 2	Mus musculus	131-135
18562474-2	2008	The main phenotypic features of frataxin-deficient human and yeast cells include iron accumulation in mitochondria, iron-sulphur cluster defects and high sensitivity to oxidative stress.	Iron	81-85	frataxin	Homo sapiens	32-40
18562474-2	2008	The main phenotypic features of frataxin-deficient human and yeast cells include iron accumulation in mitochondria, iron-sulphur cluster defects and high sensitivity to oxidative stress.	Iron	116-120	frataxin	Homo sapiens	32-40
19834550-11	2009	These findings suggest that Lcn2 has both pro-inflammatory and iron-sequestering effects along the respiratory mucosa in response to bacterial Ent.	Iron	63-67	lipocalin 2	Mus musculus	28-32
21870996-5	2011	These findings are expected to facilitate the rational design and clinical use of therapeutic agents targeting iron import via TfR1 in hematopoietic malignancies.	Iron	111-115	transferrin receptor	Homo sapiens	127-131
18768799-3	2008	Frataxin, a highly conserved small protein involved in iron-sulfur cluster synthesis, is present in both organisms, and its deficiency is responsible for Friedreich"s ataxia in humans.	Iron	55-59	frataxin	Homo sapiens	0-8
21830088-8	2011	In the event that the modified protein is expressed and stable, it is predicted that the acidic interface of frataxin, known to be involved in iron binding and interactions with the iron-sulphur cluster assembly factor IscU, would be impaired.	Iron	143-147	frataxin	Homo sapiens	109-117
18328460-0	2008	Iron chelator differentially activates macrophage inflammatory protein-3alpha/CCL20 in immortalized and malignant human oral keratinocytes.	Iron	0-4	C-C motif chemokine ligand 20	Homo sapiens	39-77
18328460-0	2008	Iron chelator differentially activates macrophage inflammatory protein-3alpha/CCL20 in immortalized and malignant human oral keratinocytes.	Iron	0-4	C-C motif chemokine ligand 20	Homo sapiens	78-83
19324495-2	2009	The characterization results (XRD, FTIR, XRF, BET, XPS, UV-vis diffuse spectra) of Fe-Mt suggested that small-sized hydrolyzed iron successfully intercalated into the interlayer spaces of the clay via pillaring.	Iron	83-85	delta/notch like EGF repeat containing	Homo sapiens	46-49
19324495-2	2009	The characterization results (XRD, FTIR, XRF, BET, XPS, UV-vis diffuse spectra) of Fe-Mt suggested that small-sized hydrolyzed iron successfully intercalated into the interlayer spaces of the clay via pillaring.	Iron	127-131	delta/notch like EGF repeat containing	Homo sapiens	46-49
19861938-2	2009	The aim of this study was to evaluate soluble transferrin receptor (sTfR) efficacy, as it is highly sensitive and specific and usually utilized in sport medicine for monitoring iron metabolism.	Iron	177-181	transferrin receptor	Homo sapiens	46-66
21893255-6	2011	In this review, we summarize and describe the recent findings involving four central players involved in keeping cellular iron homeostasis in plants: nitric oxide, ferritin, frataxin and nitrosyl iron complexes.	Iron	122-126	frataxin	Homo sapiens	174-182
19877527-7	2009	CONCLUSION: vitamin A deficiency can change cellular iron metabolism by inducing IRP2-Fn-TFR pathway.	Iron	53-57	transferrin receptor	Rattus norvegicus	89-92
18795173-11	2008	CONCLUSIONS: Iron metabolism gene variants modify lead metabolism such that HFE variants are associated with increased blood lead levels in young children.	Iron	13-17	homeostatic iron regulator	Homo sapiens	76-79
18585019-8	2008	Iron injection increased LPO only in the small intestine and that effect was completely prevented by either GH or IGF-I.	Iron	0-4	gonadotropin releasing hormone receptor	Rattus norvegicus	108-110
18585019-10	2008	GH and IGF-I possess some ability to prevent iron-induced oxidative damage in iron sensitive tissues, but contribute to oxidative imbalance in other tissues.	Iron	45-49	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
18585019-10	2008	GH and IGF-I possess some ability to prevent iron-induced oxidative damage in iron sensitive tissues, but contribute to oxidative imbalance in other tissues.	Iron	78-82	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
19877527-9	2009	Taken together, these results indicate that vitamin A deficiency can regulate iron metabolism by IRP2-TFR-Fn pathway.	Iron	78-82	transferrin receptor	Rattus norvegicus	102-105
22019886-6	2011	Expression of human IgA1 or treatment of wild-type mice with the TfR1 ligands pIgA1 or iron-loaded transferrin (Fe-Tf) accelerated recovery from acute anemia.	Iron	87-91	transferrin receptor	Mus musculus	65-69
19542226-3	2009	PTOX and AOX contain 20 highly conserved amino acids, six of which are Fe-binding ligands.	Iron	71-73	alternative oxidase 2	Arabidopsis thaliana	9-12
18752323-1	2008	Following the discovery of the HFE gene in 1996 and its linkage to the iron overload disorder hereditary hemochromatosis (HH) there have been profound developments in our understanding of the pathogenesis of the biochemical and clinical manifestations of a number of iron overload disorders.	Iron	71-75	homeostatic iron regulator	Homo sapiens	31-34
19561359-6	2009	Iron binds Sod2p in yeast mutants blocking late stages of iron-sulfur cluster biogenesis (grx5, ssq1, and atm1), but not in mutants defective in the upstream Isu proteins that serve as scaffolds for iron-sulfur biosynthesis.	Iron	0-4	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	106-110
21852233-3	2011	We showed that iron depletion using the iron chelators, desferrioxamine (DFO), or 2-hydroxy-1-napthylaldehyde isonicotinoyl hydrazone (311), increased the mRNA levels of the growth arrest and DNA damage 45alpha gene, GADD45alpha (Darnell, G. and Richardson, D. R. (1999) Blood 94, 781-792).	Iron	15-19	growth arrest and DNA damage inducible alpha	Homo sapiens	217-228
19541813-0	2009	HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients.	Iron	37-41	homeostatic iron regulator	Homo sapiens	0-3
21852233-3	2011	We showed that iron depletion using the iron chelators, desferrioxamine (DFO), or 2-hydroxy-1-napthylaldehyde isonicotinoyl hydrazone (311), increased the mRNA levels of the growth arrest and DNA damage 45alpha gene, GADD45alpha (Darnell, G. and Richardson, D. R. (1999) Blood 94, 781-792).	Iron	40-44	growth arrest and DNA damage inducible alpha	Homo sapiens	217-228
21852233-6	2011	Further, up-regulation of GADD45alpha after iron deprivation was independent of hypoxia-inducible factor-1alpha (HIF-1alpha), octamer-1 (Oct-1), p53 and early growth response 1 (Egr1).	Iron	44-48	growth arrest and DNA damage inducible alpha	Homo sapiens	26-37
21852233-7	2011	We then analyzed the regulatory elements responsible for iron depletion-mediated regulation of GADD45alpha and identified the specific transcription factor/s involved.	Iron	57-61	growth arrest and DNA damage inducible alpha	Homo sapiens	95-106
21314673-5	2009	The iron exporter ferroportin is downregulated within 1-6 h, followed by downregulation of transferrin receptor-1 (TfR1) and ferritin heavy chain (H-ferritin) mainly after 24-48 h. The hemochromatosis protein-1, a ligand of TfR1, peaked after 24 h. All effects were independent of iron supply with the exception of H-ferritin, which was restored by excess iron.	Iron	4-8	transferrin receptor	Homo sapiens	91-113
21314673-5	2009	The iron exporter ferroportin is downregulated within 1-6 h, followed by downregulation of transferrin receptor-1 (TfR1) and ferritin heavy chain (H-ferritin) mainly after 24-48 h. The hemochromatosis protein-1, a ligand of TfR1, peaked after 24 h. All effects were independent of iron supply with the exception of H-ferritin, which was restored by excess iron.	Iron	4-8	transferrin receptor	Homo sapiens	115-119
21852233-9	2011	Mutation analysis, shRNA studies, Western blotting, and electrophoretic mobility shift assays led to the identification of NF-Y in the transcriptional up-regulation of GADD45alpha after iron depletion.	Iron	186-190	growth arrest and DNA damage inducible alpha	Homo sapiens	168-179
21314673-5	2009	The iron exporter ferroportin is downregulated within 1-6 h, followed by downregulation of transferrin receptor-1 (TfR1) and ferritin heavy chain (H-ferritin) mainly after 24-48 h. The hemochromatosis protein-1, a ligand of TfR1, peaked after 24 h. All effects were independent of iron supply with the exception of H-ferritin, which was restored by excess iron.	Iron	4-8	transferrin receptor	Homo sapiens	224-228
21852233-10	2011	Furthermore, like GADD45alpha, NF-YA was up-regulated after iron chelation and down-regulated by iron supplementation.	Iron	60-64	growth arrest and DNA damage inducible alpha	Homo sapiens	18-29
21852233-10	2011	Furthermore, like GADD45alpha, NF-YA was up-regulated after iron chelation and down-regulated by iron supplementation.	Iron	97-101	growth arrest and DNA damage inducible alpha	Homo sapiens	18-29
19469713-1	2009	Aft1 is a transcriptional activator in Saccharomyces cerevisiae that responds to iron availability and regulates the expression of genes in the iron regulon, such as FET3, FTR1 and the ARN family.	Iron	144-148	ferroxidase FET3	Saccharomyces cerevisiae S288C	166-170
21297444-1	2011	Transferrin receptor (TfR), a type II transmembranous receptor involved in iron uptake, is highly expressed in some cancers.	Iron	75-79	transferrin receptor	Homo sapiens	0-20
19629184-1	2009	BACKGROUND: Friedreich ataxia (FRDA), the most common form of recessive ataxia, is due to reduced levels of frataxin, a highly conserved mitochondrial iron-chaperone involved in iron-sulfur cluster (ISC) biogenesis.	Iron	151-155	frataxin	Homo sapiens	12-29
19629184-1	2009	BACKGROUND: Friedreich ataxia (FRDA), the most common form of recessive ataxia, is due to reduced levels of frataxin, a highly conserved mitochondrial iron-chaperone involved in iron-sulfur cluster (ISC) biogenesis.	Iron	151-155	frataxin	Homo sapiens	31-35
19629184-1	2009	BACKGROUND: Friedreich ataxia (FRDA), the most common form of recessive ataxia, is due to reduced levels of frataxin, a highly conserved mitochondrial iron-chaperone involved in iron-sulfur cluster (ISC) biogenesis.	Iron	151-155	frataxin	Homo sapiens	108-116
19629184-1	2009	BACKGROUND: Friedreich ataxia (FRDA), the most common form of recessive ataxia, is due to reduced levels of frataxin, a highly conserved mitochondrial iron-chaperone involved in iron-sulfur cluster (ISC) biogenesis.	Iron	178-182	frataxin	Homo sapiens	12-29
19629184-1	2009	BACKGROUND: Friedreich ataxia (FRDA), the most common form of recessive ataxia, is due to reduced levels of frataxin, a highly conserved mitochondrial iron-chaperone involved in iron-sulfur cluster (ISC) biogenesis.	Iron	178-182	frataxin	Homo sapiens	31-35
21297444-1	2011	Transferrin receptor (TfR), a type II transmembranous receptor involved in iron uptake, is highly expressed in some cancers.	Iron	75-79	transferrin receptor	Homo sapiens	22-25
19629184-1	2009	BACKGROUND: Friedreich ataxia (FRDA), the most common form of recessive ataxia, is due to reduced levels of frataxin, a highly conserved mitochondrial iron-chaperone involved in iron-sulfur cluster (ISC) biogenesis.	Iron	178-182	frataxin	Homo sapiens	108-116
21592092-1	2011	Homozygous mutations in the gene for fatty acid 2-hydroxylase (FA2H) have been associated in humans with three neurodegenerative disorders: complicated spastic paraplegia (SPG35), leukodystrophy with spastic paraparesis and dystonia, and neurodegeneration with brain iron accumulation.	Iron	267-271	fatty acid 2-hydroxylase	Homo sapiens	37-61
19629184-8	2009	Though both mutations affected mitochondrial ISC enzymes activities and mitochondria ultrastructure, the hFXN(I154F) mutant presented a more severe phenotype with affected cytosolic and nuclear ISC enzyme activities, mitochondrial iron accumulation and an increased sensitivity to oxidative stress.	Iron	231-235	frataxin	Homo sapiens	105-110
21592092-1	2011	Homozygous mutations in the gene for fatty acid 2-hydroxylase (FA2H) have been associated in humans with three neurodegenerative disorders: complicated spastic paraplegia (SPG35), leukodystrophy with spastic paraparesis and dystonia, and neurodegeneration with brain iron accumulation.	Iron	267-271	fatty acid 2-hydroxylase	Homo sapiens	63-67
19474138-8	2009	Iron supplementation attenuated the decrement in iron status; group-by-time interactions (P &lt; 0.01) were observed for serum ferritin and soluble transferrin receptor.	Iron	0-4	transferrin receptor	Homo sapiens	148-168
21798334-0	2011	Increased iron supplied through Fet3p results in replicative life span extension of Saccharomyces cerevisiae under conditions requiring respiratory metabolism.	Iron	10-14	ferroxidase FET3	Saccharomyces cerevisiae S288C	32-37
21798334-2	2011	We now show that copper"s effect on life span is through Fet3p, a copper containing enzyme responsible for high affinity transport of iron into yeast cells.	Iron	134-138	ferroxidase FET3	Saccharomyces cerevisiae S288C	57-62
19138444-8	2009	The high-calcium diet increased hepatic copper concentration but decreased plasma copper concentration and ceruloplasmin activity, which was restored by the iron supplementation.	Iron	157-161	ceruloplasmin	Rattus norvegicus	107-120
21798334-4	2011	Extension by high iron levels is still dependent on the presence of Fet3p.	Iron	18-22	ferroxidase FET3	Saccharomyces cerevisiae S288C	68-73
21712541-11	2011	The protein interferes with JAK2/STAT5 pathways and with the mechanism of mitochondrial iron accumulation.	Iron	88-92	Janus kinase 2	Homo sapiens	28-32
21950626-6	2011	2-PNE-PIH is a caged-iron chelator that does not normally bind iron but can be activated by UVA radiation to bind iron.	Iron	21-25	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	6-9
19438852-0	2009	Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: when statistics make a difference.	Iron	36-40	beaded filament structural protein 1	Homo sapiens	58-62
21950626-6	2011	2-PNE-PIH is a caged-iron chelator that does not normally bind iron but can be activated by UVA radiation to bind iron.	Iron	63-67	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	6-9
21950626-6	2011	2-PNE-PIH is a caged-iron chelator that does not normally bind iron but can be activated by UVA radiation to bind iron.	Iron	63-67	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	6-9
19531652-5	2009	In response to TGF-beta1, there was a dramatic decrease in the FHC levels, which caused iron release from FHC and, therefore, increased the intracellular labile iron pool (LIP).	Iron	88-92	transforming growth factor, beta 1	Mus musculus	15-24
21940434-1	2011	Lipocalin 2 (Lcn2) plays an important role in defense against bacterial infection by interfering with bacterial iron acquisition.	Iron	112-116	lipocalin 2	Mus musculus	0-11
19531652-5	2009	In response to TGF-beta1, there was a dramatic decrease in the FHC levels, which caused iron release from FHC and, therefore, increased the intracellular labile iron pool (LIP).	Iron	161-165	transforming growth factor, beta 1	Mus musculus	15-24
19531652-12	2009	Our data show that cellular iron homeostasis regulated by FHC plays a critical role in TGF-beta1-induced EMT.	Iron	28-32	transforming growth factor, beta 1	Mus musculus	87-96
21940434-1	2011	Lipocalin 2 (Lcn2) plays an important role in defense against bacterial infection by interfering with bacterial iron acquisition.	Iron	112-116	lipocalin 2	Mus musculus	13-17
21907923-2	2011	Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha.	Iron	62-66	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	8-12
19201785-8	2009	The oxidative stress product malondialdehyde was increased in the iron group compared with the control group, as was the antioxidant enzyme activity of glutathione reductase and glutathione peroxidase.	Iron	66-70	glutathione reductase	Mus musculus	152-173
21755988-9	2011	This supports a model in which Hsp70 binding to apo-nNOS stabilizes an open state of the heme/substrate binding cleft to facilitate thioredoxin access to the active site cysteine that coordinates with heme iron, permitting heme binding and dimerization to the active enzyme.	Iron	206-210	nitric oxide synthase 1	Homo sapiens	52-56
23100979-9	2009	In spite of significant reduction in the immature T-cells (CD1a(+)) level after iron supplementation, it was significantly higher than the control.	Iron	80-84	CD1a molecule	Homo sapiens	59-63
19325183-1	2009	Quinol oxidation at center P of the cytochrome bc(1) complex involves bifurcated electron transfer to the Rieske iron-sulfur protein and cytochrome b.	Iron	113-117	cytochrome b	Saccharomyces cerevisiae S288C	36-48
21612955-1	2011	Mutations of the TMPRSS6 gene, encoding the serine protease matriptase-2, lead to iron-refractory iron deficiency anemia.	Iron	82-86	transmembrane serine protease 6	Mus musculus	17-24
19885382-4	2009	This novel species has an Fe(IV/III) redox potential of +1.50 V vs. ferrocene (&gt;2 V vs. NHE), the highest value thus far determined electrochemically for an iron complex.	Iron	160-164	solute carrier family 9 member C1	Homo sapiens	91-94
21612955-1	2011	Mutations of the TMPRSS6 gene, encoding the serine protease matriptase-2, lead to iron-refractory iron deficiency anemia.	Iron	82-86	transmembrane serine protease 6	Mus musculus	60-72
19384570-2	2009	In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway.	Iron	30-34	von Hippel-Lindau tumor suppressor	Homo sapiens	135-138
21788477-0	2011	How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH.	Iron	82-86	transferrin receptor	Homo sapiens	48-68
19252923-2	2009	Consequently, plants carefully regulate their iron uptake, dependent on the FRO2 ferric reductase and the IRT1 transporter, to control its homeostasis.	Iron	46-50	ferric reduction oxidase 2	Arabidopsis thaliana	76-80
21788477-1	2011	Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface.	Iron	12-16	transferrin receptor	Homo sapiens	128-148
19228020-2	2009	Cu-L1 bound 1.7 equiv of Cu and small amounts of Zn(II) and Fe.	Iron	60-62	cullin 1	Homo sapiens	0-5
21788477-1	2011	Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface.	Iron	12-16	transferrin receptor	Homo sapiens	150-153
21788477-1	2011	Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface.	Iron	50-54	transferrin receptor	Homo sapiens	128-148
21788477-1	2011	Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface.	Iron	50-54	transferrin receptor	Homo sapiens	150-153
21788477-6	2011	Iron release from each lobe then occurs by distinctly different mechanisms: Binding of His349 to the TFR (strengthened by protonation at low pH) controls iron release from the C lobe, whereas displacement of one N-lobe binding motif, in concert with the action of the dilysine trigger, elicits iron release from the N lobe.	Iron	0-4	transferrin receptor	Homo sapiens	101-104
19176888-11	2009	Further analysis indicated that iron levels in the fetal, and not maternal, liver regulate the expression of liver transferrin receptor and hepcidin expression in the mother.	Iron	32-36	transferrin receptor	Rattus norvegicus	115-135
21788477-6	2011	Iron release from each lobe then occurs by distinctly different mechanisms: Binding of His349 to the TFR (strengthened by protonation at low pH) controls iron release from the C lobe, whereas displacement of one N-lobe binding motif, in concert with the action of the dilysine trigger, elicits iron release from the N lobe.	Iron	154-158	transferrin receptor	Homo sapiens	101-104
21788477-6	2011	Iron release from each lobe then occurs by distinctly different mechanisms: Binding of His349 to the TFR (strengthened by protonation at low pH) controls iron release from the C lobe, whereas displacement of one N-lobe binding motif, in concert with the action of the dilysine trigger, elicits iron release from the N lobe.	Iron	294-298	transferrin receptor	Homo sapiens	101-104
21788477-8	2011	Collectively, the structure elucidates how the TFR accelerates iron release from the C lobe, slows it from the N lobe, and stabilizes binding of apohTF for return to the cell surface.	Iron	63-67	transferrin receptor	Homo sapiens	47-50
19211831-3	2009	We delineated the role of murine Slc11a2 [divalent metal ion transporter-1 (DMT-1)] in hippocampal neuronal iron uptake during development and memory formation.	Iron	108-112	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	33-40
21788481-5	2011	Facile [2Fe-2S] cluster transfer is observed between oxidized mNT and apo-ferredoxin (a-Fd) using UV-VIS spectroscopy and native-PAGE, as well as with a mitochondrial iron detection assay in cells.	Iron	167-171	max binding protein	Mus musculus	62-65
21788481-10	2011	The diabetes drug pioglitazone inhibits iron transfer from WT mNT to mitochondria, indicating that pioglitazone affects a specific property, [2Fe-2S] cluster transfer, in the cellular environment.	Iron	40-44	max binding protein	Mus musculus	62-65
18421081-7	2008	VIP-Perls staining demonstrated iron in the photoreceptor layer and retinal pigment epithelium that correlated with photoreceptor degeneration.	Iron	32-36	VIP peptides	Oryctolagus cuniculus	0-3
21651984-7	2011	Biological activity analysis showed that recombinant CsFerM purified from Escherichia coli exhibited apparent iron-binding activity and, when present in the culture medium of six different species of fish bacterial pathogens, completely inhibited bacterial growth.	Iron	110-114	ferritin, middle subunit	Cynoglossus semilaevis	53-59
18573874-7	2008	The impaired maturation of IRP1 upon huNbp35 depletion had profound consequences for cellular iron metabolism, leading to decreased cellular H-ferritin, increased transferrin receptor levels, and higher transferrin uptake.	Iron	94-98	aconitase 1	Homo sapiens	27-31
19264247-10	2009	Although FE(BNP) and FE(NT-proBNP) correlated strongly with each other (left: r = 0.66; right: r = 0.60; p &lt; 0.001 for both), left and right FE(NT-proBNP/BNP) ratios were not influenced by GFR (r = 0.10, p = 0.30 and r = 0.08, p = 0.43, respectively).	Iron	9-11	natriuretic peptide B	Homo sapiens	12-15
19264247-10	2009	Although FE(BNP) and FE(NT-proBNP) correlated strongly with each other (left: r = 0.66; right: r = 0.60; p &lt; 0.001 for both), left and right FE(NT-proBNP/BNP) ratios were not influenced by GFR (r = 0.10, p = 0.30 and r = 0.08, p = 0.43, respectively).	Iron	21-23	natriuretic peptide B	Homo sapiens	30-33
21651984-8	2011	In contrast, a mutant CsFerM that bears alanine substitution at two conserved residues of the ferroxidase diiron center and ferrihydrite nucleation center was abolished in both iron-binding and antimicrobial capacity.	Iron	108-112	ferritin, middle subunit	Cynoglossus semilaevis	22-28
21651984-9	2011	These results demonstrate that CsFerM is a biologically active iron chelator with broad-spectrum antibacterial activity, which suggests a role for CsFerM in not only iron storage but also innate immunity.	Iron	63-67	ferritin, middle subunit	Cynoglossus semilaevis	31-37
21651984-9	2011	These results demonstrate that CsFerM is a biologically active iron chelator with broad-spectrum antibacterial activity, which suggests a role for CsFerM in not only iron storage but also innate immunity.	Iron	166-170	ferritin, middle subunit	Cynoglossus semilaevis	31-37
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	58-62	transferrin receptor	Mus musculus	272-294
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	58-62	transferrin receptor	Mus musculus	296-300
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	transferrin receptor	Mus musculus	272-294
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	transferrin receptor	Mus musculus	296-300
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	transferrin receptor	Mus musculus	272-294
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	transferrin receptor	Mus musculus	296-300
19235971-1	2009	A new iron(III) coordination compound exhibiting a two-step spin-transition behavior with a remarkably wide [HS-LS] plateau of about 45 K has been synthesized from a hydrazino Schiff-base ligand with an N,N,O donor set, namely 2-methoxy-6-(pyridine-2-ylhydrazonomethyl)phenol (Hmph).	Iron	6-10	hematopoietically expressed homeobox	Homo sapiens	277-281
21651984-9	2011	These results demonstrate that CsFerM is a biologically active iron chelator with broad-spectrum antibacterial activity, which suggests a role for CsFerM in not only iron storage but also innate immunity.	Iron	166-170	ferritin, middle subunit	Cynoglossus semilaevis	147-153
19150326-1	2009	Under iron-deficient conditions Flavodoxin (Fld) replaces Ferredoxin in Anabaena as electron carrier from Photosystem I (PSI) to Ferredoxin-NADP(+) reductase (FNR).	Iron	6-10	ferredoxin reductase	Homo sapiens	129-157
19150326-1	2009	Under iron-deficient conditions Flavodoxin (Fld) replaces Ferredoxin in Anabaena as electron carrier from Photosystem I (PSI) to Ferredoxin-NADP(+) reductase (FNR).	Iron	6-10	ferredoxin reductase	Homo sapiens	159-162
18685102-2	2008	Mice that lack IRP2 develop microcytic anemia and neurodegeneration associated with functional cellular iron depletion caused by low TfR1 and high ferritin expression.	Iron	104-108	transferrin receptor	Mus musculus	133-137
18685102-3	2008	IRP1 knockout (IRP1(-/-)) animals do not significantly misregulate iron metabolism, partly because IRP1 is an iron-sulfur protein that functions mainly as a cytosolic aconitase in mammalian tissues and IRP2 activity increases to compensate for loss of the IRE binding form of IRP1.	Iron	110-114	aconitase 1	Homo sapiens	0-4
21651984-10	2011	These results also indicate the importance of the conserved iron uptake and mineralization sites to the function of CsFerM.	Iron	60-64	ferritin, middle subunit	Cynoglossus semilaevis	116-122
19775775-6	2011	GSK-3beta activity is up-regulated in the cells expressing H63D HFE and can be modified by the addition of iron or treatment with an iron chelator in SH-SY5Y cells expressing wild-type HFE.	Iron	107-111	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
18539898-0	2008	Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.	Iron	0-4	SMAD family member 7	Mus musculus	73-78
18539898-0	2008	Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.	Iron	0-4	atonal bHLH transcription factor 8	Mus musculus	89-94
18539898-8	2008	However, as shown by analysis of mice with liver-specific disruption of Smad4, activation of Smad7, Id1, and Atoh8 transcription by iron requires Smad4.	Iron	132-136	SMAD family member 7	Mus musculus	93-98
18539898-8	2008	However, as shown by analysis of mice with liver-specific disruption of Smad4, activation of Smad7, Id1, and Atoh8 transcription by iron requires Smad4.	Iron	132-136	atonal bHLH transcription factor 8	Mus musculus	109-114
19235734-4	2009	Flow cytometric analysis of developing Nme1(-/-)/Nme2(-/-) erythroid cells indicated that the major iron transport receptor molecule TfR1 is attenuated concomitant with a reduction of intracellular iron, suggesting that TfR1 is a downstream target of NDPKs and that reduced iron in Nme1(-/-)/Nme2(-/-) erythroblasts is inhibiting their development.	Iron	100-104	transferrin receptor	Mus musculus	133-137
19235734-4	2009	Flow cytometric analysis of developing Nme1(-/-)/Nme2(-/-) erythroid cells indicated that the major iron transport receptor molecule TfR1 is attenuated concomitant with a reduction of intracellular iron, suggesting that TfR1 is a downstream target of NDPKs and that reduced iron in Nme1(-/-)/Nme2(-/-) erythroblasts is inhibiting their development.	Iron	198-202	transferrin receptor	Mus musculus	133-137
19118623-4	2009	Our findings suggest a novel mechanistic link between dopaminergic glutathione depletion and increased iron levels based on translational activation of TfR1.	Iron	103-107	transferrin receptor	Homo sapiens	152-156
19775775-6	2011	GSK-3beta activity is up-regulated in the cells expressing H63D HFE and can be modified by the addition of iron or treatment with an iron chelator in SH-SY5Y cells expressing wild-type HFE.	Iron	107-111	homeostatic iron regulator	Homo sapiens	64-67
19775775-6	2011	GSK-3beta activity is up-regulated in the cells expressing H63D HFE and can be modified by the addition of iron or treatment with an iron chelator in SH-SY5Y cells expressing wild-type HFE.	Iron	107-111	homeostatic iron regulator	Homo sapiens	185-188
18424449-0	2008	Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia.	Iron	0-4	frataxin	Homo sapiens	29-37
18424449-2	2008	In our study, we investigated the regulation of frataxin expression by iron and demonstrated that frataxin mRNA levels decrease significantly in multiple human cell lines treated with the iron chelator, desferal (DFO).	Iron	71-75	frataxin	Homo sapiens	48-56
19775775-6	2011	GSK-3beta activity is up-regulated in the cells expressing H63D HFE and can be modified by the addition of iron or treatment with an iron chelator in SH-SY5Y cells expressing wild-type HFE.	Iron	133-137	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
18424449-2	2008	In our study, we investigated the regulation of frataxin expression by iron and demonstrated that frataxin mRNA levels decrease significantly in multiple human cell lines treated with the iron chelator, desferal (DFO).	Iron	188-192	frataxin	Homo sapiens	98-106
18424449-4	2008	Lymphoblasts and fibroblasts of FA patients have evidence of cytosolic iron depletion, as indicated by increased levels of iron regulatory protein 2 (IRP2) and/or increased IRE-binding activity of IRP1.	Iron	71-75	aconitase 1	Homo sapiens	197-201
18424449-5	2008	We postulate that this inferred cytosolic iron depletion occurs as frataxin-deficient cells overload their mitochondria with iron, a downstream regulatory effect that has been observed previously when mitochondrial iron-sulfur cluster assembly is disrupted.	Iron	42-46	frataxin	Homo sapiens	67-75
18424449-5	2008	We postulate that this inferred cytosolic iron depletion occurs as frataxin-deficient cells overload their mitochondria with iron, a downstream regulatory effect that has been observed previously when mitochondrial iron-sulfur cluster assembly is disrupted.	Iron	125-129	frataxin	Homo sapiens	67-75
18424449-5	2008	We postulate that this inferred cytosolic iron depletion occurs as frataxin-deficient cells overload their mitochondria with iron, a downstream regulatory effect that has been observed previously when mitochondrial iron-sulfur cluster assembly is disrupted.	Iron	125-129	frataxin	Homo sapiens	67-75
19283345-5	2009	It has been suggested that frataxin function is that of a ferritin-like protein, an iron chaperone of the iron sulphur cluster machinery and heme metabolism and/or a controller of cellular oxidative stress.	Iron	84-88	frataxin	Homo sapiens	27-35
19252502-7	2009	TfR1-mediated iron uptake promoted osteoclast differentiation and bone-resorbing activity, associated with the induction of mitochondrial respiration, production of reactive oxygen species and accelerated Ppargc1b transcription.	Iron	14-18	transferrin receptor	Mus musculus	0-4
19252502-9	2009	These data establish mitochondrial biogenesis orchestrated by PGC-1beta, coupled with iron uptake through TfR1 and iron supply to mitochondrial respiratory proteins, as a fundamental pathway linked to osteoclast activation and bone metabolism.	Iron	86-90	transferrin receptor	Mus musculus	106-110
18424449-6	2008	The mitochondrial iron overload and presumed cytosolic iron depletion potentially further compromise function in frataxin-deficient cells by decreasing frataxin expression.	Iron	18-22	frataxin	Homo sapiens	113-121
18424449-6	2008	The mitochondrial iron overload and presumed cytosolic iron depletion potentially further compromise function in frataxin-deficient cells by decreasing frataxin expression.	Iron	18-22	frataxin	Homo sapiens	152-160
19775775-6	2011	GSK-3beta activity is up-regulated in the cells expressing H63D HFE and can be modified by the addition of iron or treatment with an iron chelator in SH-SY5Y cells expressing wild-type HFE.	Iron	133-137	homeostatic iron regulator	Homo sapiens	64-67
18424449-6	2008	The mitochondrial iron overload and presumed cytosolic iron depletion potentially further compromise function in frataxin-deficient cells by decreasing frataxin expression.	Iron	55-59	frataxin	Homo sapiens	113-121
18424449-6	2008	The mitochondrial iron overload and presumed cytosolic iron depletion potentially further compromise function in frataxin-deficient cells by decreasing frataxin expression.	Iron	55-59	frataxin	Homo sapiens	152-160
19323016-6	2009	Out of 76 HbE homozygotes, hematological parameters of 7 individuals with iron deficiency improved after iron supplementation.	Iron	74-78	hemoglobin subunit epsilon 1	Homo sapiens	10-13
19775775-6	2011	GSK-3beta activity is up-regulated in the cells expressing H63D HFE and can be modified by the addition of iron or treatment with an iron chelator in SH-SY5Y cells expressing wild-type HFE.	Iron	133-137	homeostatic iron regulator	Homo sapiens	185-188
19775775-8	2011	These results suggest H63D HFE increases tau phosphorylation via GSK-3beta activity and iron-mediated oxidative stress.	Iron	88-92	homeostatic iron regulator	Homo sapiens	27-30
20392616-9	2011	Hyperferritinemia was associated with increased vascular damage only in patients with HFE genotypes associated with hepcidin upregulation by iron stores (p&lt;0.0001), and serum hepcidin-25 was independently associated with carotid plaques (p=0.05).	Iron	141-145	homeostatic iron regulator	Homo sapiens	86-89
19178276-3	2009	SPL is a member of the radical AdoMet superfamily of enzymes, and utilizes an iron-sulfur cluster and S-adenosylmethionine to repair SP by a direct reversal mechanism initiated by H atom abstraction from C-6 of the thymine dimer.	Iron	78-82	sphingosine-1-phosphate lyase 1	Homo sapiens	0-3
18400414-3	2008	Individuals with hemochromatosis gene (HFE) mutations: C282Y and H63D, which result in a less efficient transport of iron by macrophages, are characterized by an increased risk for venous leg ulcer and multiple sclerosis.	Iron	117-121	homeostatic iron regulator	Homo sapiens	39-42
21901660-0	2011	Non-HFE hepatic iron overload.	Iron	16-20	homeostatic iron regulator	Homo sapiens	4-7
18635001-2	2008	The small molecule NSC306711 inhibits iron uptake from the Tf-TfR pathway.	Iron	38-42	transferrin receptor	Homo sapiens	62-65
19243223-3	2009	A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384.	Iron	182-186	nuclear receptor subfamily 1 group D member 2	Homo sapiens	33-44
21901660-5	2011	Ferroportin disease, the most common non- HFE hereditary iron-loading disorder, is caused by a loss of iron export function of FPN resulting in early and preferential iron accumulation in Kupffer cells and macrophages with high ferritin levels and low-to-normal transferrin saturation.	Iron	57-61	homeostatic iron regulator	Homo sapiens	42-45
19164527-0	2009	A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump.	Iron	26-28	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	84-104
18540637-0	2008	Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.	Iron	55-59	frataxin	Drosophila melanogaster	11-19
21777743-9	2011	In association, myocardial iron content was reduced in HF versus non-HF samples (0.49 +- 0.07 mug/g vs. 0.58 +- 0.09 mug/g, p &lt; 0.05), and there was a significant reduction (p &lt; 0.05) in the myocardial mRNA expression of Tfr1, which plays a key role in cellular iron transport.	Iron	27-31	transferrin receptor	Homo sapiens	227-231
18540637-1	2008	Frataxin, a mitochondrial protein that is directly involved in regulating cellular iron homeostasis, has been suggested to serve as an iron chaperone during cellular Fe-S cluster biosynthesis.	Iron	83-87	frataxin	Drosophila melanogaster	0-8
18540637-1	2008	Frataxin, a mitochondrial protein that is directly involved in regulating cellular iron homeostasis, has been suggested to serve as an iron chaperone during cellular Fe-S cluster biosynthesis.	Iron	135-139	frataxin	Drosophila melanogaster	0-8
18540637-1	2008	Frataxin, a mitochondrial protein that is directly involved in regulating cellular iron homeostasis, has been suggested to serve as an iron chaperone during cellular Fe-S cluster biosynthesis.	Iron	166-170	frataxin	Drosophila melanogaster	0-8
18540637-4	2008	In this report, we have characterized the overall stability and iron binding properties of the Drosophila frataxin homologue (Dfh).	Iron	64-68	frataxin	Drosophila melanogaster	106-124
18540637-4	2008	In this report, we have characterized the overall stability and iron binding properties of the Drosophila frataxin homologue (Dfh).	Iron	64-68	frataxin	Drosophila melanogaster	126-129
18540637-8	2008	Under anaerobic conditions with salt present, holo-Dfh is a stable iron-loaded protein monomer.	Iron	67-71	frataxin	Drosophila melanogaster	51-54
18540637-10	2008	Ferrous iron bound to Dfh is high-spin and held in a partially symmetric Fe-(O/N) 6 coordination environment, as determined by X-ray absorption spectroscopy (XAS).	Iron	0-12	frataxin	Drosophila melanogaster	22-25
18540637-10	2008	Ferrous iron bound to Dfh is high-spin and held in a partially symmetric Fe-(O/N) 6 coordination environment, as determined by X-ray absorption spectroscopy (XAS).	Iron	0-2	frataxin	Drosophila melanogaster	22-25
18540637-13	2008	Finally, frataxin mediates the delivery of Fe(II) to Isu, promoting Fe-S cluster assembly in vitro.	Iron	43-45	frataxin	Drosophila melanogaster	9-17
18540637-14	2008	The Dfh-assisted assembly of Fe-S clusters occurs with an observed kinetic rate constant ( k obs) of 0.096 min (-1).	Iron	29-33	frataxin	Drosophila melanogaster	4-7
19096759-5	2009	In support of this hypothesis, our data show that three different classes of enzymes in this iron- and 2-oxoglutarate-dependent dioxygenase family, including HIF-prolyl hydroxylase PHD2, histone demethylase JHDM2A/JMJD1A, and DNA repair enzyme ABH3, are all highly sensitive to nickel inhibition.	Iron	93-97	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	244-248
19174578-7	2009	Examples of potentially informative genes include LCT (lactase), ALDH2 (aldehyde dehydrogenase), and HFE (hemochromatosis), proxies, respectively, for dairy product intake, alcoholic beverage drinking, and serum iron levels.	Iron	212-216	lactase	Homo sapiens	50-53
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	24-28	transferrin receptor	Homo sapiens	253-256
21354213-0	2011	Dopamine D(3) receptor deficiency sensitizes mice to iron deficiency-related deficits in motor learning.	Iron	53-57	dopamine receptor D3	Mus musculus	0-22
18590611-6	2008	Although the functions of BTBD9 remain uncertain, its biological plausibility is evidenced by its dose-dependent relationship to periodic limb movements of sleep, decrements in iron stores, and ethnic differences in RLS prevalence.	Iron	177-181	BTB domain containing 9	Homo sapiens	26-31
19013457-6	2009	Mice made iron-deficient by diet had an increase in the density of striatal adenosine A(2A) (A(2A)R) but not A(1) receptor (A(1)R) compared to mice on a normal diet.	Iron	10-14	adenosine A2a receptor	Mus musculus	93-99
19013457-7	2009	Between two inbred murine strains, which had 2-fold differences in their striatal iron concentrations under normal dietary conditions, the strain with the lower striatal iron had the highest striatal A(2A)R density.	Iron	170-174	adenosine A2a receptor	Mus musculus	200-206
19013457-9	2009	In these cells, A(2A)R agonist-induced cyclic AMP production was enhanced in response to iron chelation, also demonstrating a functional upregulation of A(2A)R.	Iron	89-93	adenosine A2a receptor	Mus musculus	16-22
19013457-9	2009	In these cells, A(2A)R agonist-induced cyclic AMP production was enhanced in response to iron chelation, also demonstrating a functional upregulation of A(2A)R.	Iron	89-93	adenosine A2a receptor	Mus musculus	153-159
19013457-10	2009	A significant correlation (r(2)=0.79) was found between a primary marker of cellular iron status (transferrin receptor (TfR)) and A(2A)R protein density.	Iron	85-89	transferrin receptor	Mus musculus	98-118
21822737-1	2011	AIM: To find out the association of common HFE mutations (viz., C282Y and H63D) with primary iron overload (PIL) in liver cirrhosis (CLD) patients of Indian origin.	Iron	93-97	homeostatic iron regulator	Homo sapiens	43-46
19013457-10	2009	A significant correlation (r(2)=0.79) was found between a primary marker of cellular iron status (transferrin receptor (TfR)) and A(2A)R protein density.	Iron	85-89	transferrin receptor	Mus musculus	120-123
19013457-10	2009	A significant correlation (r(2)=0.79) was found between a primary marker of cellular iron status (transferrin receptor (TfR)) and A(2A)R protein density.	Iron	85-89	adenosine A2a receptor	Mus musculus	130-136
19013457-11	2009	In conclusion, the A(2A)R is increased across different iron-insufficient conditions.	Iron	56-60	adenosine A2a receptor	Mus musculus	19-25
19013457-12	2009	The relation between A(2A)R and cellular iron status may be an important pathway by which adenosine may alter the function of the dopaminergic system.	Iron	41-45	adenosine A2a receptor	Mus musculus	21-27
18445768-3	2008	We found that transferrin receptor 1 (TfR1), a major iron importer, is highly expressed in foamy macrophages and some smooth muscle cells in intimal lesions of human carotid atheroma, mainly in cytoplasmic accumulation patterns.	Iron	53-57	transferrin receptor	Homo sapiens	14-36
18445768-3	2008	We found that transferrin receptor 1 (TfR1), a major iron importer, is highly expressed in foamy macrophages and some smooth muscle cells in intimal lesions of human carotid atheroma, mainly in cytoplasmic accumulation patterns.	Iron	53-57	transferrin receptor	Homo sapiens	38-42
18331251-7	2008	The strong positive correlation between hepatic DNA damage and iron overload suggests that iron content is one of the most likely mediators of hepatic oxidative stress and iron reduction may be beneficial to reduce the incidence of hepatic cancer in CH-C patients.	Iron	91-95	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	250-254
21510633-3	2011	X-ray absorption spectroscopy (XAS) of metallated (Fe and Ni) samples of ABH2 was used to investigate the mechanism of ABH2 and its inhibition by Ni(II) ions.	Iron	51-53	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	73-77
18331251-7	2008	The strong positive correlation between hepatic DNA damage and iron overload suggests that iron content is one of the most likely mediators of hepatic oxidative stress and iron reduction may be beneficial to reduce the incidence of hepatic cancer in CH-C patients.	Iron	91-95	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	250-254
19023602-6	2009	Analysis of this model has led also to assignment of motifs in Fox1 that are unique to ferroxidases, the strongest evidence to date that the well-characterized fungal high-affinity iron uptake system is essential to iron homeostasis in green algae.	Iron	181-185	uncharacterized protein	Chlamydomonas reinhardtii	63-67
19023602-6	2009	Analysis of this model has led also to assignment of motifs in Fox1 that are unique to ferroxidases, the strongest evidence to date that the well-characterized fungal high-affinity iron uptake system is essential to iron homeostasis in green algae.	Iron	216-220	uncharacterized protein	Chlamydomonas reinhardtii	63-67
19066835-3	2009	TfR mediates iron accumulation and reactive oxygen formation and thereby enhanced proliferation in clonal human glioma lines, as shown by the following experiments: (1) downregulating TfR expression reduced proliferation in vitro and in vivo; (2) forced TfR expression in low-grade glioma accelerated proliferation to the level of high-grade glioma; (3) iron and oxidant chelators attenuated tumor proliferation in vitro and tumor size in vivo.	Iron	354-358	transferrin receptor	Homo sapiens	0-3
21510633-3	2011	X-ray absorption spectroscopy (XAS) of metallated (Fe and Ni) samples of ABH2 was used to investigate the mechanism of ABH2 and its inhibition by Ni(II) ions.	Iron	51-53	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	119-123
21426424-3	2011	To maintain iron homeostasis, the expression of FRO2 and IRT1 is tightly controlled by iron deficiency at the transcriptional level.	Iron	12-16	ferric reduction oxidase 2	Arabidopsis thaliana	48-52
19134195-5	2009	We also showed Akt/GSK-3beta signaling pathways are involved in iron nanoparticle-induced cell permeability.	Iron	64-68	glycogen synthase kinase 3 beta	Homo sapiens	19-28
19134195-6	2009	The inhibition of ROS demonstrate ROS play a major role in regulating Akt/GSK-3beta - mediated cell permeability upon iron nanoparticle exposure.	Iron	118-122	glycogen synthase kinase 3 beta	Homo sapiens	74-83
19907150-3	2009	Since the discovery of the HFE gene in 1996, it has been possible to predict the risk of developing iron overload by a simple blood test to detect C282Y homozygotes of the HFE gene.	Iron	100-104	homeostatic iron regulator	Homo sapiens	27-30
19907150-3	2009	Since the discovery of the HFE gene in 1996, it has been possible to predict the risk of developing iron overload by a simple blood test to detect C282Y homozygotes of the HFE gene.	Iron	100-104	homeostatic iron regulator	Homo sapiens	172-175
18433447-9	2008	Collectively, the data suggest trypanosome frataxin functions primarily only in Fe-S cluster biogenesis and protection from reactive oxygen species.	Iron	80-82	frataxin	Homo sapiens	43-51
18541582-8	2008	The effect sizes of iron intervention trials were significantly greater for change in iron reserves estimated by BI-TfR/ferritin than by BI-ferritin in 2 studies with larger effect sizes (1.11 compared with 1.00 and 1.56 compared with 1.44, respectively; P &lt; 0.05) and 1 study with medium effect size (0.70 compared with 0.57; P &lt; 0.05).	Iron	20-24	transferrin receptor	Homo sapiens	116-119
18541582-8	2008	The effect sizes of iron intervention trials were significantly greater for change in iron reserves estimated by BI-TfR/ferritin than by BI-ferritin in 2 studies with larger effect sizes (1.11 compared with 1.00 and 1.56 compared with 1.44, respectively; P &lt; 0.05) and 1 study with medium effect size (0.70 compared with 0.57; P &lt; 0.05).	Iron	86-90	transferrin receptor	Homo sapiens	116-119
21426424-4	2011	The basic helix-loop-helix (bHLH) transcription factor FIT represents the most upstream actor known in the iron-deficiency signaling pathway, and directly regulates the expression of the root iron uptake machinery genes FRO2 and IRT1.	Iron	107-111	ferric reduction oxidase 2	Arabidopsis thaliana	220-224
21426424-10	2011	In addition, we showed that FIT post-translational regulation by iron is required for FRO2 and IRT1 gene expression.	Iron	65-69	ferric reduction oxidase 2	Arabidopsis thaliana	86-90
18456853-7	2008	The predominant sulfate-reducing bacterial species were Desulfovibrio spp., while the iron reducers were represented by Ferribacterium spp.	Iron	86-90	histocompatibility minor 13	Homo sapiens	135-138
18782082-2	2009	The purified enzyme was purple and contained substoichiometric amounts of iron and zinc; however, metal-binding studies reveal that GLX2-1 can bind nearly two equivalents of either iron or zinc and that the most stable analogue of GLX2-1 is the iron-containing form.	Iron	74-78	glyoxalase 2-1	Arabidopsis thaliana	132-138
21527675-6	2011	This interaction with viperin, but not with a mutant lacking the viperin iron-sulfur cluster-binding motif, reduced cellular ATP generation, which resulted in actin cytoskeleton disruption and enhancement of infection.	Iron	73-77	radical S-adenosyl methionine domain containing 2	Homo sapiens	22-29
18782082-2	2009	The purified enzyme was purple and contained substoichiometric amounts of iron and zinc; however, metal-binding studies reveal that GLX2-1 can bind nearly two equivalents of either iron or zinc and that the most stable analogue of GLX2-1 is the iron-containing form.	Iron	181-185	glyoxalase 2-1	Arabidopsis thaliana	132-138
18782082-2	2009	The purified enzyme was purple and contained substoichiometric amounts of iron and zinc; however, metal-binding studies reveal that GLX2-1 can bind nearly two equivalents of either iron or zinc and that the most stable analogue of GLX2-1 is the iron-containing form.	Iron	181-185	glyoxalase 2-1	Arabidopsis thaliana	132-138
23045014-2	2009	PAH is a non-heme-iron-dependent protein that normally catalyzes the C-oxidation of phenylalanine (Phe) to tyrosine (Tyr) in the presence of BH(4), utilizing molecular dioxygen as an additional substrate.	Iron	18-22	phenylalanine hydroxylase	Homo sapiens	0-3
17712531-1	2008	Hemopexin (HPX) has two principal roles: it sequesters free heme in vivo for the purpose of preventing the toxic effects of this moiety, which is largely due to heme"s ability to catalyze free radical formation, and it transports heme intracellularly thus limiting its availability as an iron source for pathogens.	Iron	288-292	hemopexin	Homo sapiens	0-9
21367862-0	2011	Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis.	Iron	82-86	cytosolic iron-sulfur assembly component 3	Homo sapiens	19-23
18367876-0	2008	Iron chelator-based amplification strategy for improved targeting of transferrin receptor with SPIO.	Iron	0-4	transferrin receptor	Homo sapiens	69-89
18367876-3	2008	Here, we describe an amplification strategy that uses iron chelators to upregulate the transferrin receptor (TfR) prior to administration of TfR-targeted superparamagnetic iron oxide nanoparticles (SPIO).	Iron	54-58	transferrin receptor	Homo sapiens	87-107
18367876-3	2008	Here, we describe an amplification strategy that uses iron chelators to upregulate the transferrin receptor (TfR) prior to administration of TfR-targeted superparamagnetic iron oxide nanoparticles (SPIO).	Iron	54-58	transferrin receptor	Homo sapiens	109-112
18367876-6	2008	The results reported here suggest that iron chelators have the potential to significantly improve the sensitivity of TfR-mediated cancer detection, providing a new paradigm for MR signal amplification.	Iron	39-43	transferrin receptor	Homo sapiens	117-120
18781344-3	2009	A significant amount of iron was always found in Agrobacterium radiobacter hydantoinase purified from unsupplemented cobalt-, manganese-, or zinc-amended Escherichia coli cell cultures.	Iron	24-28	AWN88_RS03840	Agrobacterium tumefaciens	75-87
19817702-10	2009	Elevations in available iron affect changes in the expression of Dcytb, DMT1, ferritin, and FPN1, which further modify metal homeostasis in the lung.	Iron	24-28	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	72-76
21367862-3	2011	Iron-only hydrogenase-like protein 1 (IOP1; also known as nuclear prelamin A recognition factor like protein, or NARFL) is a human protein that is homologous to Nar1, a protein in Saccharomyces cerevisiae that, in turn, is an essential component of the cytosolic iron-sulfur protein assembly pathway in yeast.	Iron	263-267	cytosolic iron-sulfur assembly component 3	Homo sapiens	0-36
19008010-0	2009	Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study.	Iron	12-16	homeostatic iron regulator	Homo sapiens	87-90
18425540-0	2008	Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein.	Iron	8-12	frataxin	Homo sapiens	36-44
18425540-0	2008	Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein.	Iron	91-93	frataxin	Homo sapiens	36-44
18425540-1	2008	Frataxin is an iron binding mitochondrial matrix protein that has been shown to mediate iron delivery during iron-sulfur cluster and heme biosynthesis.	Iron	15-19	frataxin	Homo sapiens	0-8
21367862-3	2011	Iron-only hydrogenase-like protein 1 (IOP1; also known as nuclear prelamin A recognition factor like protein, or NARFL) is a human protein that is homologous to Nar1, a protein in Saccharomyces cerevisiae that, in turn, is an essential component of the cytosolic iron-sulfur protein assembly pathway in yeast.	Iron	263-267	cytosolic iron-sulfur assembly component 3	Homo sapiens	38-42
18425540-1	2008	Frataxin is an iron binding mitochondrial matrix protein that has been shown to mediate iron delivery during iron-sulfur cluster and heme biosynthesis.	Iron	88-92	frataxin	Homo sapiens	0-8
18425540-1	2008	Frataxin is an iron binding mitochondrial matrix protein that has been shown to mediate iron delivery during iron-sulfur cluster and heme biosynthesis.	Iron	88-92	frataxin	Homo sapiens	0-8
18425540-7	2008	Nevertheless, the iron-dependent binding affinity of each frataxin derivative to the iron-sulfur cluster scaffold protein ISU is found to be similar to that of native frataxin, as defined by isothermal titration calorimetry experiments, requiring only one iron center to promote nanomolar binding.	Iron	18-22	frataxin	Homo sapiens	58-66
18425540-7	2008	Nevertheless, the iron-dependent binding affinity of each frataxin derivative to the iron-sulfur cluster scaffold protein ISU is found to be similar to that of native frataxin, as defined by isothermal titration calorimetry experiments, requiring only one iron center to promote nanomolar binding.	Iron	85-89	frataxin	Homo sapiens	58-66
18425540-7	2008	Nevertheless, the iron-dependent binding affinity of each frataxin derivative to the iron-sulfur cluster scaffold protein ISU is found to be similar to that of native frataxin, as defined by isothermal titration calorimetry experiments, requiring only one iron center to promote nanomolar binding.	Iron	85-89	frataxin	Homo sapiens	58-66
18945820-7	2009	AMPK activation by oltipraz contributed to cell survival, which was supported by the reversal of oltipraz"s restoration of mitochondrial membrane potential by concomitant treatment of compound C. By the same token, an AMPK activator inhibited AA + iron-induced mitochondrial permeability transition with an increase in cell viability.	Iron	248-252	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
18945820-7	2009	AMPK activation by oltipraz contributed to cell survival, which was supported by the reversal of oltipraz"s restoration of mitochondrial membrane potential by concomitant treatment of compound C. By the same token, an AMPK activator inhibited AA + iron-induced mitochondrial permeability transition with an increase in cell viability.	Iron	248-252	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	218-222
18945820-8	2009	Moreover, new 1,2-dithiole-3-thiones with the capability of AMPK activation protected cells from mitochondrial permeability transition and ROS overproduction induced by AA + iron.	Iron	174-178	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	60-64
18945820-9	2009	Our results demonstrate that oltipraz and new 1,2-dithiole-3-thiones are capable of protecting cells from AA + iron-induced ROS production and mitochondrial dysfunction, which may be associated with AMPK activation.	Iron	111-115	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	199-203
21367862-3	2011	Iron-only hydrogenase-like protein 1 (IOP1; also known as nuclear prelamin A recognition factor like protein, or NARFL) is a human protein that is homologous to Nar1, a protein in Saccharomyces cerevisiae that, in turn, is an essential component of the cytosolic iron-sulfur protein assembly pathway in yeast.	Iron	263-267	cytosolic iron-sulfur assembly component 3	Homo sapiens	113-118
19000728-6	2009	Further experiments observed that Rg1 pre-treatment substantially attenuated MPTP-elevated iron levels, decreased DMT1 expression and increased FP1 expression in the SN.	Iron	91-95	protein phosphatase 1, regulatory subunit 3A	Mus musculus	34-37
21367862-3	2011	Iron-only hydrogenase-like protein 1 (IOP1; also known as nuclear prelamin A recognition factor like protein, or NARFL) is a human protein that is homologous to Nar1, a protein in Saccharomyces cerevisiae that, in turn, is an essential component of the cytosolic iron-sulfur protein assembly pathway in yeast.	Iron	263-267	cytosolic iron-sulfur assembly component 3	Homo sapiens	161-165
19000728-7	2009	These results suggest that the neuroprotective effect of Rg1 on dopaminergic neurons against MPTP is due to the ability to reduce nigral iron levels, which is achieved by regulating the expressions of DMT1 and FP1.	Iron	137-141	protein phosphatase 1, regulatory subunit 3A	Mus musculus	57-60
21367862-9	2011	Therefore, just as with knock-out of Nar1 in yeast, we find that knock-out of Iop1/Narfl in mice results in lethality and defective cytosolic iron-sulfur cluster assembly.	Iron	142-146	cytosolic iron-sulfur assembly component 3	Homo sapiens	83-88
18500222-7	2008	The overall prevalence of HFE mutations was 40.9% among hemodialysis patients, 30.6% among patients with laboratory findings of iron overload and 15.8% among blood donors.	Iron	128-132	homeostatic iron regulator	Homo sapiens	26-29
21238504-6	2011	Knockdown of Flvcr in mice leads to both defective erythropoiesis and disturbed systemic iron homeostasis, underscoring the critical role of heme transporters in mammalian physiology.	Iron	89-93	feline leukemia virus subgroup C cellular receptor 1	Mus musculus	13-18
18500222-9	2008	Prevalence of HFE mutation in this group was 40.9%, significantly higher than results observed among blood donors (15.8%, P&lt;0.005) or among patients with laboratory signs of iron overload (30.6%, P&lt;0.01).	Iron	177-181	homeostatic iron regulator	Homo sapiens	14-17
18796625-2	2008	Friedreich ataxia (FRDA), a deficiency in the mitochondrial iron-chaperone frataxin, results in defective use of iron and its misdistribution between mitochondria and cytosol.	Iron	60-64	frataxin	Homo sapiens	0-17
18796625-2	2008	Friedreich ataxia (FRDA), a deficiency in the mitochondrial iron-chaperone frataxin, results in defective use of iron and its misdistribution between mitochondria and cytosol.	Iron	60-64	frataxin	Homo sapiens	75-83
18796625-2	2008	Friedreich ataxia (FRDA), a deficiency in the mitochondrial iron-chaperone frataxin, results in defective use of iron and its misdistribution between mitochondria and cytosol.	Iron	113-117	frataxin	Homo sapiens	0-17
18796625-2	2008	Friedreich ataxia (FRDA), a deficiency in the mitochondrial iron-chaperone frataxin, results in defective use of iron and its misdistribution between mitochondria and cytosol.	Iron	113-117	frataxin	Homo sapiens	75-83
18796625-4	2008	Adding the chelator deferiprone at clinical concentrations to inducibly frataxin-deficient HEK-293 cells resulted in chelation of mitochondrial labile iron involved in oxidative stress and in reactivation of iron-depleted aconitase.	Iron	151-155	frataxin	Homo sapiens	72-80
18796625-4	2008	Adding the chelator deferiprone at clinical concentrations to inducibly frataxin-deficient HEK-293 cells resulted in chelation of mitochondrial labile iron involved in oxidative stress and in reactivation of iron-depleted aconitase.	Iron	208-212	frataxin	Homo sapiens	72-80
18475237-3	2008	Stella Iron Cloud is a member of the Oglala Sioux Tribe.	Iron	7-11	developmental pluripotency associated 3	Homo sapiens	0-6
21333694-1	2011	Cellular iron metabolism is essentially controlled by the binding of cytosolic iron regulatory proteins (IRP1 or IRP2) to iron-responsive elements (IREs) located on mRNAs coding for proteins involved in iron acquisition, utilization and storage.	Iron	9-13	aconitase 1	Homo sapiens	105-109
21863743-4	2011	The inhibitory effects of ODC (a heme-dependent inhibitor of sGC) and isatin were non-additive suggesting that the inhibitory effect of isatin may involve the heme binding domain (possibly heme iron) and experiments with hemin revealed some isatin-dependent changes in its spectrum.	Iron	194-198	ornithine decarboxylase 1	Homo sapiens	26-29
18822958-4	2008	As a result, DHA effectively decreased the TfR content and down-regulated TfR protein expression in normal iron HL60 and K562 cells in a dose- and time-dependent manner and inhibited the cell proliferation.	Iron	107-111	transferrin receptor	Homo sapiens	74-77
18822958-6	2008	DHA exerted more pronounced inhibitory action on expression of TfR protein and mRNA in iron overload K562 cells.	Iron	87-91	transferrin receptor	Homo sapiens	63-66
18822958-7	2008	Compared to normal iron K562 cells, the TfR protein and mRNA levels were lowered by 28.1% (P &lt; 0.01) and 26.	Iron	19-23	transferrin receptor	Homo sapiens	40-43
18817857-8	2008	Genomic analysis of the promoter regions of these two frog hepcidin genes indicates that transcription regulation factors NF-kappaB and C/EBPbeta may be involved in hepcidin regulation by iron.	Iron	188-192	hepcidin 1	Xenopus tropicalis	59-67
18817857-8	2008	Genomic analysis of the promoter regions of these two frog hepcidin genes indicates that transcription regulation factors NF-kappaB and C/EBPbeta may be involved in hepcidin regulation by iron.	Iron	188-192	hepcidin 1	Xenopus tropicalis	165-173
20369315-7	2011	When adults were compared, iron-treated animals presented significantly higher Par-4 and caspase-3 immunoreactivities in CA1, CA3 and cortex.	Iron	27-31	caspase 3	Rattus norvegicus	89-98
19058322-4	2008	Shortly after its discovery in 1996, the hemochromatosis protein HFE was shown to physically interact with transferrin receptor 1 (TfR1) and impair the uptake of transferrin-bound iron in cells.	Iron	180-184	homeostatic iron regulator	Homo sapiens	65-68
19058322-4	2008	Shortly after its discovery in 1996, the hemochromatosis protein HFE was shown to physically interact with transferrin receptor 1 (TfR1) and impair the uptake of transferrin-bound iron in cells.	Iron	180-184	transferrin receptor	Homo sapiens	131-135
19058322-8	2008	Recent studies with animal models of HH uncover a crucial role of HFE as a hepatocyte iron sensor and upstream regulator of hepcidin.	Iron	86-90	homeostatic iron regulator	Homo sapiens	66-69
19058322-9	2008	Thus, hepatocyte HFE is indispensable for signaling to hepcidin, presumably as a constituent of a larger iron-sensing complex.	Iron	105-109	homeostatic iron regulator	Homo sapiens	17-20
18495927-2	2008	Thus, erythroid precursor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds to the transferrin receptor (TfR) at the cell surface.	Iron	67-71	transferrin receptor	Homo sapiens	130-150
18495927-2	2008	Thus, erythroid precursor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds to the transferrin receptor (TfR) at the cell surface.	Iron	67-71	transferrin receptor	Homo sapiens	152-155
18495927-2	2008	Thus, erythroid precursor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds to the transferrin receptor (TfR) at the cell surface.	Iron	88-92	transferrin receptor	Homo sapiens	130-150
18495927-2	2008	Thus, erythroid precursor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds to the transferrin receptor (TfR) at the cell surface.	Iron	88-92	transferrin receptor	Homo sapiens	152-155
21243331-6	2011	A single T-A substitution in Lx2 changes histidine H532 (one of the iron-binding ligands essential for L-2 activity) to glutamine.	Iron	68-72	seed linoleate 9S-lipoxygenase-2	Glycine max	29-32
18451267-7	2008	TMPRSS6 is an essential component of a pathway that detects iron deficiency and blocks Hamp transcription, permitting enhanced dietary iron absorption.	Iron	60-64	transmembrane serine protease 6	Mus musculus	0-7
18164223-14	2008	Our results in phlebotomized patients suggest that the depletion of iron stores may further exacerbate the HFE-related hepcidin defect.	Iron	68-72	homeostatic iron regulator	Homo sapiens	107-110
19020684-7	2008	In this critical review, we wish to provide a concise background on the chemistry of the mononuclear non-heme iron enzymes characterized by the 2-His-1-carboxylate facial triad and to discuss the many recent developments in the field.	Iron	110-114	viral integration site 1	Homo sapiens	146-151
21355094-8	2011	Furthermore, these results suggest that natural genetic variation in the human ortholog TMPRSS6 might modify the clinical penetrance of HFE-associated hereditary hemochromatosis, raising the possibility that pharmacologic inhibition of TMPRSS6 could attenuate iron loading in this disorder.	Iron	260-264	homeostatic iron regulator	Homo sapiens	136-139
19034258-3	2008	Non-HFE associated HH is caused by mutations in other recently identified genes involved in iron metabolism.	Iron	92-96	homeostatic iron regulator	Homo sapiens	4-7
18525129-2	2008	In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998.	Iron	99-103	homeostatic iron regulator	Homo sapiens	72-75
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	96-100	transferrin	Sus scrofa	142-153
18429831-6	2008	Mucin production was evident on PAS and colloid iron staining.	Iron	48-52	LOC100508689	Homo sapiens	0-5
18953029-5	2008	Disruption of the IRE/IRP interaction could greatly affect iron metabolism.	Iron	59-63	Wnt family member 2	Homo sapiens	22-25
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	96-100	transferrin	Sus scrofa	155-157
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	115-119	transferrin	Sus scrofa	142-153
21297163-2	2011	Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised of transferring-binding protein (Tbp) A and B.	Iron	115-119	transferrin	Sus scrofa	155-157
18984440-5	2008	After the anemia resolved with the treatment of the peptic ulcer and iron supplementation, the TAT and D-dimer levels were normalized, and the occluded veins were recanalized.	Iron	69-73	tyrosine aminotransferase	Homo sapiens	95-98
21173098-8	2011	Conclusions Our results are consistent with a scenario in which TFR2 plays a prominent and HFE a contributory role in the hepcidin response to a dose of oral iron.	Iron	158-162	homeostatic iron regulator	Homo sapiens	91-94
18393441-0	2008	Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer.	Iron	24-28	frataxin	Homo sapiens	49-57
18393441-0	2008	Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer.	Iron	101-105	frataxin	Homo sapiens	49-57
21228038-0	2011	Iron overload in HFE C282Y heterozygotes at first genetic testing: a strategy for identifying rare HFE variants.	Iron	0-4	homeostatic iron regulator	Homo sapiens	17-20
18393441-1	2008	The mitochondrial protein frataxin plays a central role in mitochondrial iron homeostasis, and frataxin deficiency is responsible for Friedreich ataxia, a neurodegenerative and cardiac disease that affects 1 in 40000 children.	Iron	73-77	frataxin	Homo sapiens	26-34
18393441-2	2008	Here we present a single-particle reconstruction from cryoelectron microscopic images of iron-loaded 24-subunit oligomeric frataxin particles at 13 and 17 A resolution.	Iron	89-93	frataxin	Homo sapiens	123-131
18393441-5	2008	The reconstructions show the iron core of frataxin for the first time.	Iron	29-33	frataxin	Homo sapiens	42-50
18665838-1	2008	Haem-regulated eIF2alpha kinase (HRI) is essential for the regulation of globin gene translation and the survival of erythroid precursors in iron/haem deficiency.	Iron	141-145	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	33-36
18694968-7	2008	In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe(-/-) and beta2m(-/-), show an increased susceptibility to experimental infection with M. avium and that during infection these animals accumulate iron inside granuloma macrophages.	Iron	78-82	beta-2 microglobulin	Mus musculus	117-123
18694968-7	2008	In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe(-/-) and beta2m(-/-), show an increased susceptibility to experimental infection with M. avium and that during infection these animals accumulate iron inside granuloma macrophages.	Iron	254-258	beta-2 microglobulin	Mus musculus	117-123
21228038-0	2011	Iron overload in HFE C282Y heterozygotes at first genetic testing: a strategy for identifying rare HFE variants.	Iron	0-4	homeostatic iron regulator	Homo sapiens	99-102
18341276-3	2008	Crystallographic characterization of sym-[1(CO)](+) confirmed a C2-symmetric structure with a bridging CO ligand and an elongated Fe-Fe bond of 2.7012(14) A, as predicted previously.	Iron	130-132	noggin	Homo sapiens	37-43
18974697-7	2008	These negative effects are particularly evident in carriers of the common HFE gene"s mutations C282Y and H63D, because intracellular iron deposits of mutated macrophages have less stability than those of the wild type, inducing a significant oxidative stress.	Iron	133-137	homeostatic iron regulator	Homo sapiens	74-77
21346098-0	2011	HFE gene variants affect iron in the brain.	Iron	25-29	homeostatic iron regulator	Homo sapiens	0-3
18597060-6	2008	OxVLDL modified by copper or iron ions increased the expression of PAI-1 and HSF1 in EC compared to VLDL or LDL.	Iron	29-33	heat shock transcription factor 1	Homo sapiens	77-81
18341276-3	2008	Crystallographic characterization of sym-[1(CO)](+) confirmed a C2-symmetric structure with a bridging CO ligand and an elongated Fe-Fe bond of 2.7012(14) A, as predicted previously.	Iron	133-135	noggin	Homo sapiens	37-43
21346098-3	2011	One of the mechanisms leading to iron overload is a mutation in the HFE gene, which is involved in iron metabolism.	Iron	33-37	homeostatic iron regulator	Homo sapiens	68-71
21346098-3	2011	One of the mechanisms leading to iron overload is a mutation in the HFE gene, which is involved in iron metabolism.	Iron	99-103	homeostatic iron regulator	Homo sapiens	68-71
21346098-10	2011	Importantly, the data herein also begin to dispel the long-held view that the brain is protected from iron accumulation associated with the HFE mutations.	Iron	102-106	homeostatic iron regulator	Homo sapiens	140-143
18345610-1	2008	Iron depletion, using iron chelators targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective in the treatment of cancer.	Iron	0-4	transferrin receptor	Homo sapiens	47-67
18513375-1	2008	FRO2 (At1g01580) codes for an NADPH-dependent ferric reductase in plasma membranes of root epidermal cells with a demonstrated role in iron uptake by plants.	Iron	135-139	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
18345610-1	2008	Iron depletion, using iron chelators targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective in the treatment of cancer.	Iron	0-4	transferrin receptor	Homo sapiens	69-72
21346101-2	2011	Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2.	Iron	0-4	CYCS pseudogene 51	Homo sapiens	67-71
18345610-1	2008	Iron depletion, using iron chelators targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective in the treatment of cancer.	Iron	22-26	transferrin receptor	Homo sapiens	47-67
18345610-1	2008	Iron depletion, using iron chelators targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective in the treatment of cancer.	Iron	22-26	transferrin receptor	Homo sapiens	69-72
21346101-6	2011	Integration of the IRE-RNA in translation regulators (near the cap) or turnover elements (after the coding region) increases iron uptake (DMT1/TRF1) or decreases iron storage/efflux (FTN/FPN) when IRP binds.	Iron	125-129	Wnt family member 2	Homo sapiens	197-200
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	39-43	transferrin receptor	Homo sapiens	85-105
18809870-10	2008	The heterozygote MC3R Gly104Ser polymorphism was associated with greater FE in selected males (P = 0.03) and greater BW in unselected males (P = 0.007).	Iron	73-75	melanocortin 3 receptor	Homo sapiens	17-21
20957368-4	2011	The CyaY protein can bind ferric iron and serve as an iron donor for the biogenesis of iron-sulfur clusters on the scaffold protein IscU in the presence of IscS and L-cysteine in vitro.	Iron	33-37	NFS1 cysteine desulfurase	Homo sapiens	156-160
18311129-8	2008	In E. cuniculi, the iron (frataxin) and sulphur (cysteine desulphurase, Nfs1) donors and the scaffold protein (Isu1) co-localize with mitochondrial Hsp70 to the mitosome, consistent with it being the functional site for Fe-S cluster biosynthesis.	Iron	20-24	frataxin	Homo sapiens	26-34
20957368-4	2011	The CyaY protein can bind ferric iron and serve as an iron donor for the biogenesis of iron-sulfur clusters on the scaffold protein IscU in the presence of IscS and L-cysteine in vitro.	Iron	54-58	frataxin	Homo sapiens	4-8
18823557-12	2008	Potential effector molecules are different antimicrobial peptides and lysozymes, but also transferrin that can inhibit bacterial growth through iron-depletion.	Iron	144-148	Transferrin 1	Drosophila melanogaster	90-101
20957368-4	2011	The CyaY protein can bind ferric iron and serve as an iron donor for the biogenesis of iron-sulfur clusters on the scaffold protein IscU in the presence of IscS and L-cysteine in vitro.	Iron	54-58	NFS1 cysteine desulfurase	Homo sapiens	156-160
21175851-0	2011	Two novel mutations in the SLC40A1 and HFE genes implicated in iron overload in a Spanish man.	Iron	63-67	homeostatic iron regulator	Homo sapiens	39-42
18258795-0	2008	Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators.	Iron	67-71	arachidonate 12-lipoxygenase, 12S type	Rattus norvegicus	13-41
21149283-1	2011	The level of body iron storage and the erythropoietic need for iron are indicated by the serum levels of ferritin and soluble transferrin receptor (sTfR), respectively.	Iron	18-22	transferrin receptor	Homo sapiens	126-146
18396134-2	2008	Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.	Iron	106-110	Wnt family member 2	Homo sapiens	52-55
18396134-2	2008	Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.	Iron	106-110	homeostatic iron regulator	Homo sapiens	192-195
18396134-2	2008	Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.	Iron	135-139	Wnt family member 2	Homo sapiens	52-55
18396134-2	2008	Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.	Iron	135-139	homeostatic iron regulator	Homo sapiens	192-195
18396134-2	2008	Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.	Iron	135-139	Wnt family member 2	Homo sapiens	52-55
17916327-2	2008	The iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane receptor, a periplasmic binding protein (PBP), and an inner membrane ATP-binding cassette (ABC) transporter.	Iron	4-8	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	201-221
17916327-2	2008	The iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane receptor, a periplasmic binding protein (PBP), and an inner membrane ATP-binding cassette (ABC) transporter.	Iron	4-8	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	223-226
17916327-6	2008	Examination of the current three-dimensional structures of the outer membrane receptors, PBPs, and ABC transporters provides an overview of the structural biology of iron uptake in bacteria.	Iron	166-170	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	99-102
18519167-3	2008	In this study, we examined Lcn2 regulation in the liver of mice in situations of increased iron utilization, namely, during anemia.	Iron	91-95	lipocalin 2	Mus musculus	27-31
21149283-1	2011	The level of body iron storage and the erythropoietic need for iron are indicated by the serum levels of ferritin and soluble transferrin receptor (sTfR), respectively.	Iron	63-67	transferrin receptor	Homo sapiens	126-146
18552213-2	2008	Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1).	Iron	6-10	transferrin receptor	Mus musculus	113-133
18552213-2	2008	Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1).	Iron	6-10	transferrin receptor	Mus musculus	135-139
18258192-1	2008	In Friedreich"s ataxia, reduction of the mitochondria protein frataxin results in the accumulation of iron and reactive oxygen species, which leads to oxidative damage, neurodegeneration and a diminished lifespan.	Iron	102-106	frataxin	Drosophila melanogaster	62-70
20556443-4	2011	Increased expression of divalent metal transporter 1 and decreased expression of ferroportin 1 might associate with this increased nigral iron levels.	Iron	138-142	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	24-52
18304497-4	2008	A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease.	Iron	119-123	aconitase 1	Homo sapiens	143-147
18304497-5	2008	ISCU interacts with the Friedreich ataxia gene product frataxin in iron-sulfur cluster biosynthesis.	Iron	67-71	frataxin	Homo sapiens	55-63
18552213-11	2008	We conclude that STAT5A/B is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 transcription.	Iron	55-59	transferrin receptor	Mus musculus	116-120
18585019-0	2008	Protective effects of GH and IGF-I against iron-induced lipid peroxidation in vivo.	Iron	43-47	gonadotropin releasing hormone receptor	Rattus norvegicus	22-24
21332426-3	2011	The hemochromatosis (HFE) gene p.H63D and p.C282Y polymorphisms have been linked to dysregulation of iron metabolism and increased levels of ROS, whereas Angiotensin II receptor 1 (AGTR1) c.1166A   C polymorphism is known as a vascular risk factor.	Iron	101-105	homeostatic iron regulator	Homo sapiens	21-24
18549825-2	2008	We previously found that lack of aldose reductase (AR), the first enzyme of the polyol pathway, attenuated the increase in transferrin (Tf) level in I/R brain, suggesting that AR contributes to iron-catalyzed free radical-induced damage.	Iron	194-198	aldo-keto reductase family 1 member B1	Rattus norvegicus	33-49
18549825-2	2008	We previously found that lack of aldose reductase (AR), the first enzyme of the polyol pathway, attenuated the increase in transferrin (Tf) level in I/R brain, suggesting that AR contributes to iron-catalyzed free radical-induced damage.	Iron	194-198	aldo-keto reductase family 1 member B1	Rattus norvegicus	51-53
18549825-2	2008	We previously found that lack of aldose reductase (AR), the first enzyme of the polyol pathway, attenuated the increase in transferrin (Tf) level in I/R brain, suggesting that AR contributes to iron-catalyzed free radical-induced damage.	Iron	194-198	aldo-keto reductase family 1 member B1	Rattus norvegicus	176-178
18549825-4	2008	We found that inhibition of AR or sorbitol dehydrogenase (SDH), the second enzyme of the polyol pathway, both attenuated the I/R-mediated increases in HIF-1alpha, Tf, TfR, and intracellular iron content and reduced the I/R-induced infarct area of the heart.	Iron	190-194	sorbitol dehydrogenase	Rattus norvegicus	28-56
18549825-7	2008	This activates HIF-1alpha that induces the expression of TfR, which in turn increases Tf uptake and iron accumulation and exacerbates oxidative damage that increases the lipid peroxidation.	Iron	100-104	transferrin receptor	Rattus norvegicus	57-60
18316026-2	2008	We developed mutant mouse strains to gain insight into the role of the Hfe/Tfr1 complex in regulating iron homeostasis.	Iron	102-106	transferrin receptor	Mus musculus	75-79
18316026-4	2008	Under conditions favoring a constitutive Hfe/Tfr1 interaction, mice developed iron overload attributable to inappropriately low expression of the hormone hepcidin.	Iron	78-82	transferrin receptor	Mus musculus	45-49
18268542-8	2008	Overexpression of FIT with either AtbHLH38 or AtbHLH39 in plants converted the expression of the iron uptake genes FRO2 and IRT1 from induced to constitutive.	Iron	97-101	ferric reduction oxidase 2	Arabidopsis thaliana	115-119
18711158-1	2008	The discovery of the HFE gene in 1996 heralded a decade of major advances in the understanding of the mechanisms that control iron absorption and body iron stores.	Iron	126-130	homeostatic iron regulator	Homo sapiens	21-24
21336162-6	2011	RESULTS: Dietary iron intake was positively associated with serum alanine aminotransferase levels (standardized coefficient beta = 2.35, P = 0.019).	Iron	17-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	124-132
18711158-1	2008	The discovery of the HFE gene in 1996 heralded a decade of major advances in the understanding of the mechanisms that control iron absorption and body iron stores.	Iron	151-155	homeostatic iron regulator	Homo sapiens	21-24
18403150-4	2008	We show that in this family the mutation which is fully penetrant, may act through an increased iron export from macrophages as suggested by the unexpected absence of iron overload in the spleen and bone marrow detected by magnetic resonance imaging, that it co-segregates with a phenotype close to the classical form of HFE-associated hemochromatosis and was associated, in the oldest patient, with the development of hepatocellular carcinoma in a non cirrhotic liver.	Iron	96-100	homeostatic iron regulator	Homo sapiens	321-324
21097466-2	2011	RTEL1, an essential iron-sulfur cluster-containing helicase, is a dominant factor that controls telomere length in mice and is required for telomere integrity.	Iron	20-24	regulator of telomere elongation helicase 1	Mus musculus	0-5
18029550-4	2008	Incubation of cells with doxorubicin (DOX) up-regulated mRNA levels of the iron-regulated genes transferrin receptor-1 (TfR1) and N-myc downstream-regulated gene-1 (Ndrg1).	Iron	75-79	transferrin receptor	Homo sapiens	96-118
18029550-4	2008	Incubation of cells with doxorubicin (DOX) up-regulated mRNA levels of the iron-regulated genes transferrin receptor-1 (TfR1) and N-myc downstream-regulated gene-1 (Ndrg1).	Iron	75-79	transferrin receptor	Homo sapiens	120-124
18206656-4	2008	Frataxin plays a crucial role in iron metabolism and detoxification and interacts with electron transport chain proteins.	Iron	33-37	frataxin	Homo sapiens	0-8
21051716-4	2011	Transferrin receptor mRNA (Tfrc), an indicator of iron levels, was quantified by qPCR.	Iron	50-54	transferrin receptor	Mus musculus	0-20
18585964-7	2008	There was 100% concordance of HFE genotype C282Y/C282Y in 6 probands and 8 of their siblings who reported having hemochromatosis or iron overload.	Iron	132-136	homeostatic iron regulator	Homo sapiens	30-33
17879349-4	2008	Analysis of samples of native lipoxygenase-3 produced ions corresponding within experimental error to the mass of the N-acetylated polypeptide and one iron atom.	Iron	151-155	seed linoleate 9S-lipoxygenase-3	Glycine max	30-44
21051716-4	2011	Transferrin receptor mRNA (Tfrc), an indicator of iron levels, was quantified by qPCR.	Iron	50-54	transferrin receptor	Mus musculus	27-31
21062905-5	2011	We identified two putative quantitative trait loci (QTL) that contain genes with a known role in iron metabolism: Eif2ak1 and Igf2r.	Iron	97-101	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	114-121
18189390-8	2008	We also have used hybrid quantum mechanical/molecular mechanics (QM/MM) techniques to analyze the heme-NO structure and the Fe-NO bond strength in the different NP4 conformations.	Iron	124-126	proteinase 3	Homo sapiens	161-164
18189390-10	2008	In contrast to most heme proteins that control ligand affinity by modulating the bond strength to the iron, NP4 has evolved a cage mechanism that traps the NO at low pH and releases it upon cage opening when the pH rises.	Iron	102-106	proteinase 3	Homo sapiens	108-111
18239941-0	2008	Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma.	Iron	62-66	beaded filament structural protein 1	Homo sapiens	82-86
18239941-5	2008	METHODS: Enhancement of MAL-induced PpIX accumulation by the iron chelator CP94 was quantified fluorometrically in human cultured cells (including three dermatological cell types).	Iron	61-65	beaded filament structural protein 1	Homo sapiens	75-79
18239941-7	2008	RESULTS: Large enhancements in PpIX accumulation were observed in the cultured cells when co-incubated with the iron chelator CP94.	Iron	112-116	beaded filament structural protein 1	Homo sapiens	126-130
18239941-10	2008	CONCLUSION: Iron chelation by CP94 is an effective enhancer of MAL-induced PpIX accumulation in vitro.	Iron	12-16	beaded filament structural protein 1	Homo sapiens	30-34
21062905-5	2011	We identified two putative quantitative trait loci (QTL) that contain genes with a known role in iron metabolism: Eif2ak1 and Igf2r.	Iron	97-101	insulin-like growth factor 2 receptor	Mus musculus	126-131
18524764-16	2008	These results suggest that HFE decreases the stability of Zip14 and therefore reduces the iron loading in HepG2 cells.	Iron	90-94	homeostatic iron regulator	Homo sapiens	27-30
21115478-4	2011	All genes identified as suppressors of high iron toxicity in aerobically grown Deltaccc1 cells encode organelle iron transporters including mitochondrial iron transporters MRS3, MRS4, and RIM2.	Iron	44-48	Rim2p	Saccharomyces cerevisiae S288C	188-192
18070921-7	2008	The fusion of the Yap5 cysteine-containing domains to a GAL4 DNA binding domain results in iron-sensitive GAL1-lacZ expression.	Iron	91-95	galactokinase	Saccharomyces cerevisiae S288C	106-110
21360641-2	2011	Iron regulatory proteins (IRPs, IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	0-4	aconitase 1	Homo sapiens	32-36
18083798-0	2008	The Arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron to developing seeds.	Iron	78-82	oligopeptide transporter	Arabidopsis thaliana	16-22
18083798-5	2008	Phenotypic analyses of opt3-2 plants revealed three interesting loss-of-function phenotypes associated with iron metabolism.	Iron	108-112	oligopeptide transporter	Arabidopsis thaliana	23-27
18584434-2	2008	BET surface area of Kemiron is 39.8 m(2)/g and Electron dispersive spectroscopy (EDS) studies found Kemiron to be 40.37% iron and 42.25% oxygen by mass.	Iron	23-27	delta/notch like EGF repeat containing	Homo sapiens	0-3
18756096-1	2008	In our previous study, the expression of active H-ferritins in Saccharomyces cerevisiae was found to reduce cell growth and reactive oxygen species (ROS) generation upon exposure to oxidative stress; such expression enhanced that of high-affinity iron transport genes (FET3 and FTR1).	Iron	247-251	ferroxidase FET3	Saccharomyces cerevisiae S288C	269-273
18083798-6	2008	First, reduced AtOPT3 expression in opt3-2 plants resulted in the constitutive expression of root iron deficiency responses regardless of exogenous iron supply.	Iron	98-102	oligopeptide transporter	Arabidopsis thaliana	15-21
21360641-2	2011	Iron regulatory proteins (IRPs, IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	81-85	aconitase 1	Homo sapiens	32-36
18083798-6	2008	First, reduced AtOPT3 expression in opt3-2 plants resulted in the constitutive expression of root iron deficiency responses regardless of exogenous iron supply.	Iron	98-102	oligopeptide transporter	Arabidopsis thaliana	36-40
18083798-7	2008	Second, deregulation of root iron uptake processes in opt3-2 roots resulted in the accumulation of very high levels of iron in opt3-2 tissues.	Iron	29-33	oligopeptide transporter	Arabidopsis thaliana	54-58
18083798-7	2008	Second, deregulation of root iron uptake processes in opt3-2 roots resulted in the accumulation of very high levels of iron in opt3-2 tissues.	Iron	29-33	oligopeptide transporter	Arabidopsis thaliana	127-131
18083798-7	2008	Second, deregulation of root iron uptake processes in opt3-2 roots resulted in the accumulation of very high levels of iron in opt3-2 tissues.	Iron	119-123	oligopeptide transporter	Arabidopsis thaliana	54-58
18083798-7	2008	Second, deregulation of root iron uptake processes in opt3-2 roots resulted in the accumulation of very high levels of iron in opt3-2 tissues.	Iron	119-123	oligopeptide transporter	Arabidopsis thaliana	127-131
18606475-3	2008	Recently, the spectrum of diseases attributable to abnormal Fe-S cluster biogenesis has extended beyond Friedreich ataxia to include a sideroblastic anemia with deficiency of glutaredoxin 5 and a myopathy associated with a deficiency of a Fe-S cluster assembly scaffold protein, ISCU.	Iron	60-64	glutaredoxin	Homo sapiens	175-187
18519569-8	2008	The consequent changes in TfR1 expression may be involved in modulating iron retention in inflammatory macrophages, thus possibly contributing to the development of hypoferremia in the early phases preceding the down-regulation of macrophage ferroportin by hepcidin.	Iron	72-76	transferrin receptor	Mus musculus	26-30
18083798-8	2008	Hyperaccumulation of iron in opt3-2 resulted in the formation of brown necrotic areas in opt3-2 leaves and was more pronounced during the seed-filling stage.	Iron	21-25	oligopeptide transporter	Arabidopsis thaliana	29-33
21394295-6	2011	RESULTS: The up-regulated genes on day 7 by hPDL cells cultured in osteogenic medium were thought to be associated with calcium/iron/metal ion binding or homeostasis (PDE1A, HFE and PCDH9) and cell viability (PCDH9), and the down-regulated genes were thought to be associated with proliferation (PHGDH and PSAT1).	Iron	128-132	programmed cell death 1	Homo sapiens	44-48
18083798-8	2008	Hyperaccumulation of iron in opt3-2 resulted in the formation of brown necrotic areas in opt3-2 leaves and was more pronounced during the seed-filling stage.	Iron	21-25	oligopeptide transporter	Arabidopsis thaliana	89-93
18046454-7	2008	When this interaction is impaired, Fes remains in focal adhesions and as a consequence the cells show defective spreading and scattering in response to HGF stimulation.	Iron	35-38	hepatocyte growth factor	Homo sapiens	152-155
18627600-9	2008	In addition, we show that the drug resistance regulator gene YRR1 and the iron homeostasis regulator gene AFT2 are both directly regulated by Yap1p.	Iron	74-78	Yrr1p	Saccharomyces cerevisiae S288C	61-65
21394295-6	2011	RESULTS: The up-regulated genes on day 7 by hPDL cells cultured in osteogenic medium were thought to be associated with calcium/iron/metal ion binding or homeostasis (PDE1A, HFE and PCDH9) and cell viability (PCDH9), and the down-regulated genes were thought to be associated with proliferation (PHGDH and PSAT1).	Iron	128-132	homeostatic iron regulator	Homo sapiens	174-177
18450746-1	2008	Heme-regulated eukaryotic initiation factor 2alpha (eIF2alpha) kinase (HRI) functions in response to the heme iron concentration.	Iron	110-114	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	71-74
18450746-2	2008	At the appropriate heme iron concentrations under normal conditions, HRI function is suppressed by binding of the heme iron.	Iron	24-28	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	69-72
18046454-8	2008	Altogether, these results provide a novel mechanism whereby ezrin/Fes interaction at cell-cell contacts plays an essential role in HGF-induced cell scattering and implicates Fes in the cross-talk between cell-cell and cell-matrix adhesion.	Iron	66-69	hepatocyte growth factor	Homo sapiens	131-134
18046454-8	2008	Altogether, these results provide a novel mechanism whereby ezrin/Fes interaction at cell-cell contacts plays an essential role in HGF-induced cell scattering and implicates Fes in the cross-talk between cell-cell and cell-matrix adhesion.	Iron	174-177	hepatocyte growth factor	Homo sapiens	131-134
18450746-2	2008	At the appropriate heme iron concentrations under normal conditions, HRI function is suppressed by binding of the heme iron.	Iron	119-123	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	69-72
21394295-6	2011	RESULTS: The up-regulated genes on day 7 by hPDL cells cultured in osteogenic medium were thought to be associated with calcium/iron/metal ion binding or homeostasis (PDE1A, HFE and PCDH9) and cell viability (PCDH9), and the down-regulated genes were thought to be associated with proliferation (PHGDH and PSAT1).	Iron	128-132	phosphoserine aminotransferase 1	Homo sapiens	306-311
18450746-3	2008	Conversely, upon heme iron shortage, HRI autophosphorylates and subsequently phosphorylates the substrate, eIF2alpha, leading to the termination of protein synthesis.	Iron	22-26	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	37-40
19066423-0	2008	Multi-organ iron overload in an African-American man with ALAS2 R452S and SLC40A1 R561G.	Iron	12-16	5'-aminolevulinate synthase 2	Homo sapiens	58-63
20959604-1	2011	The divalent metal ion transporter DMT1 is critical for nonheme iron import.	Iron	64-68	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	35-39
19066423-1	2008	BACKGROUND: X-linked sideroblastic anemia (XLSA) is associated with iron overload and mutations in ALAS2, which encodes 5-aminolevulinate synthase.	Iron	68-72	5'-aminolevulinate synthase 2	Homo sapiens	12-41
19066423-1	2008	BACKGROUND: X-linked sideroblastic anemia (XLSA) is associated with iron overload and mutations in ALAS2, which encodes 5-aminolevulinate synthase.	Iron	68-72	5'-aminolevulinate synthase 2	Homo sapiens	43-47
18540637-0	2008	Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.	Iron	24-28	frataxin	Drosophila melanogaster	11-19
19066423-10	2008	CONCLUSIONS: ALAS2 R452S largely explains this patient"s microcytic anemia and multi-organ iron overload and dysfunction.	Iron	91-95	5'-aminolevulinate synthase 2	Homo sapiens	13-18
18537827-0	2008	Dynamics, stability and iron-binding activity of frataxin clinical mutants.	Iron	24-28	frataxin	Homo sapiens	49-57
20959604-3	2011	Here we report that in Ndfip1(-/-) mice fed a low- iron diet, DMT1 expression and activity in duodenal enterocytes are significant higher than in the wild-type animals.	Iron	51-55	Nedd4 family interacting protein 1	Mus musculus	23-29
20959604-3	2011	Here we report that in Ndfip1(-/-) mice fed a low- iron diet, DMT1 expression and activity in duodenal enterocytes are significant higher than in the wild-type animals.	Iron	51-55	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	62-66
20959604-5	2011	Liver and spleen iron stores were also increased in Ndfip1(-/-) mice fed a normal diet.	Iron	17-21	Nedd4 family interacting protein 1	Mus musculus	52-58
20959604-6	2011	Counterintuitive to the increase in iron uptake, Ndfip1(-/-) mice fed a low iron diet develop severe microcytic, hypochromic anemia.	Iron	76-80	Nedd4 family interacting protein 1	Mus musculus	49-55
20959604-8	2011	These data demonstrate that Ndfip1 is a critical mediator of DMT1 regulation in vivo, particularly under iron restricted conditions.	Iron	105-109	Nedd4 family interacting protein 1	Mus musculus	28-34
17938904-3	2008	Zinc depletion severely affects ethanol production and therefore nicotinamide adenine dinucleotide (NAD) regeneration, although we observed partial compensation by the upregulation of the poorly efficient Fe-dependent Adh4p in our conditions.	Iron	205-207	alcohol dehydrogenase ADH4	Saccharomyces cerevisiae S288C	218-223
20959604-8	2011	These data demonstrate that Ndfip1 is a critical mediator of DMT1 regulation in vivo, particularly under iron restricted conditions.	Iron	105-109	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	61-65
18489257-0	2008	Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.	Iron	9-13	Wnt family member 2	Homo sapiens	87-90
21725738-3	2011	The current study investigated the effect of RBC lysis and iron release on brain tTG levels and neuronal death in a rat model of ICH.	Iron	59-63	transglutaminase 2	Rattus norvegicus	81-84
18489257-0	2008	Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.	Iron	34-38	Wnt family member 2	Homo sapiens	87-90
18489257-4	2008	We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis.	Iron	66-70	Wnt family member 2	Homo sapiens	119-122
18489257-4	2008	We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis.	Iron	90-94	Wnt family member 2	Homo sapiens	119-122
18489257-5	2008	We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.	Iron	158-162	Wnt family member 2	Homo sapiens	28-31
21725738-7	2011	Both hemoglobin and iron mimicked the effects of lysed RBCs, resulting in tTG expression and neuronal death (p&lt;0.05).	Iron	20-24	transglutaminase 2	Rattus norvegicus	74-77
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	24-28	transferrin receptor	Homo sapiens	0-11
21490768-5	2011	Using flow cytometry techniques, we found that both the TfR-deficient mature RBC and their TfR-containing precursors at all stages of maturation can take up non-Tf iron that accumulates as redox-active labile iron and generates reactive oxygen species.	Iron	164-168	transferrin receptor	Homo sapiens	56-59
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	24-28	transferrin receptor	Homo sapiens	13-16
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	104-108	transferrin receptor	Homo sapiens	0-11
21490768-5	2011	Using flow cytometry techniques, we found that both the TfR-deficient mature RBC and their TfR-containing precursors at all stages of maturation can take up non-Tf iron that accumulates as redox-active labile iron and generates reactive oxygen species.	Iron	164-168	transferrin receptor	Homo sapiens	91-94
17872962-2	2008	Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release.	Iron	104-108	transferrin receptor	Homo sapiens	13-16
17872962-3	2008	Iron-free Tf (apo-Tf) is then brought back to the cell surface and dissociates from TfR.	Iron	0-4	transferrin receptor	Homo sapiens	84-87
21490768-5	2011	Using flow cytometry techniques, we found that both the TfR-deficient mature RBC and their TfR-containing precursors at all stages of maturation can take up non-Tf iron that accumulates as redox-active labile iron and generates reactive oxygen species.	Iron	209-213	transferrin receptor	Homo sapiens	56-59
21490768-5	2011	Using flow cytometry techniques, we found that both the TfR-deficient mature RBC and their TfR-containing precursors at all stages of maturation can take up non-Tf iron that accumulates as redox-active labile iron and generates reactive oxygen species.	Iron	209-213	transferrin receptor	Homo sapiens	91-94
21061168-2	2011	The first step of iron transport from the blood to the brain is transferrin receptor (TfR)-mediated endocytosis in the capillary endothelial cells.	Iron	18-22	transferrin receptor	Rattus norvegicus	64-84
18177727-5	2008	We demonstrate that IRPs control the expression of divalent metal transporter 1 (DMT1) mRNA and protein, a limiting intestinal iron importer.	Iron	127-131	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	51-79
21061168-2	2011	The first step of iron transport from the blood to the brain is transferrin receptor (TfR)-mediated endocytosis in the capillary endothelial cells.	Iron	18-22	transferrin receptor	Rattus norvegicus	86-89
18177727-5	2008	We demonstrate that IRPs control the expression of divalent metal transporter 1 (DMT1) mRNA and protein, a limiting intestinal iron importer.	Iron	127-131	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	81-85
21061168-8	2011	Furthermore, the expression of Tf and TfR in the blood vessels precedes its expression in oligodendrocytes, the main iron-storing cells in the vertebrate brain.	Iron	117-121	transferrin receptor	Rattus norvegicus	38-41
21061168-10	2011	The specific expression of Tf and TfR in brain perivascular cells and MTP-1 and hephaestin in endothelial cells suggest the possibility that trafficking of elemental iron through perivascular cells may be instrumental in the distribution of iron in the developing central nervous system.	Iron	166-170	transferrin receptor	Rattus norvegicus	34-37
21176807-3	2011	Non-HFE-associated HH is caused by mutations in other recently identified genes involved in iron metabolism.	Iron	92-96	homeostatic iron regulator	Homo sapiens	4-7
18605935-11	2008	CONCLUSIONS: In addition to reflecting the activity of erythropoiesis, S-TfR seems to reflect iron balance in preterm neonates.	Iron	94-98	transferrin receptor	Homo sapiens	73-76
21966538-0	2011	The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells.	Iron	92-96	prominin 1	Homo sapiens	39-49
21966538-0	2011	The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells.	Iron	92-96	prominin 1	Homo sapiens	50-55
21966538-11	2011	Taken together, these data extend our knowledge of the function of CD133 and underline the interest of further exploring the CD133-Tf-iron network.	Iron	134-138	prominin 1	Homo sapiens	67-72
18005180-0	2008	Analysis of the HFE gene (H63D and C282Y) mutations in patients with iron overload, family members and controls from Antioquia, Northwest Colombia.	Iron	69-73	homeostatic iron regulator	Homo sapiens	16-19
21655188-6	2011	In irradiated recipients that received hmox(+/-) or hmox(+/+) bone marrow cells, we evaluated (i) the erythrocyte parameters in the peripheral blood; (ii) the staining intensity of CD71-, Ter119-, and CD49d-specific surface markers during erythroblast differentiation; (iii) the patterns of histological iron staining; and (iv) the number of Mac-1(+)-cells expressing TNF-alpha.	Iron	304-308	transferrin receptor	Mus musculus	181-185
17959863-0	2008	Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutations.	Iron	89-93	homeostatic iron regulator	Homo sapiens	109-112
20974481-11	2011	The results suggest that a suitable PRB material for the removal of As(III) under anoxic conditions can be produced through the deposition of a coating of FeS onto natural silica sand with an iron-oxide coating.	Iron	155-158	RB transcriptional corepressor 1	Homo sapiens	36-39
17959863-8	2008	CONCLUSIONS: Iron depletion ameliorates insulin secretion and sensitivity in NGT and diabetic carriers of HFE gene mutations.	Iron	13-17	homeostatic iron regulator	Homo sapiens	106-109
18061182-6	2008	Thirteen (8.02%) were heterozygotes for C282Y HFE gene mutation and had higher hepatic iron scores (3.6 +/- 3.8 vs 1.9 +/- 2.8, respectively, P = .05).	Iron	87-91	homeostatic iron regulator	Homo sapiens	46-49
20724023-0	2010	AtFer4 ferritin is a determinant of iron homeostasis in Arabidopsis thaliana heterotrophic cells.	Iron	36-40	ferritin 4	Arabidopsis thaliana	0-6
18274988-1	2008	Iron regulatory protein 1 (IRP1) controls the translation or stability of several mRNAs by binding to iron responsive elements (IREs) within their untranslated regions.	Iron	102-106	aconitase 1	Homo sapiens	0-25
18274988-1	2008	Iron regulatory protein 1 (IRP1) controls the translation or stability of several mRNAs by binding to iron responsive elements (IREs) within their untranslated regions.	Iron	102-106	aconitase 1	Homo sapiens	27-31
18274988-3	2008	Thus, in iron-replete cells, IRP1 assembles a cubane [4Fe-4S] cluster that prevents RNA-binding activity and renders the protein to cytosolic aconitase.	Iron	9-13	aconitase 1	Homo sapiens	29-33
18274988-4	2008	We show that wild type or mutant forms of IRP1 that fail to assemble a [4Fe-4S] cluster are sensitized for iron-dependent degradation by the ubiquitin-proteasome pathway.	Iron	107-111	aconitase 1	Homo sapiens	42-46
20724023-4	2010	Although no reduction in total ferritin or in mitochondrial ferritin was observed in atfer4 mutants, total iron content increased in atfer4 cells and in atfer4 mitochondria.	Iron	107-111	ferritin 4	Arabidopsis thaliana	133-139
20724023-4	2010	Although no reduction in total ferritin or in mitochondrial ferritin was observed in atfer4 mutants, total iron content increased in atfer4 cells and in atfer4 mitochondria.	Iron	107-111	ferritin 4	Arabidopsis thaliana	133-139
20724023-5	2010	Transcript correlation analysis highlighted a partial inverse relationship between the transcript levels of the mitochondrial ferric reductase oxidase FRO3, putatively involved in mitochondrial iron import/export, and AtFer4.	Iron	194-198	ferritin 4	Arabidopsis thaliana	218-224
18031036-2	2007	The crystal structure reveals a bent Fe-N-O geometry and an eta2-(C,S) bonding mode between iron and the C-S bond.	Iron	92-96	DNA polymerase iota	Homo sapiens	60-64
20724023-7	2010	We propose that the complex molecular network maintaining Fe cellular homeostasis requires, in Arabidopsis heterotrophic cells, a proper balance of the different ferritin isoforms, and that alteration of this equilibrium, such as that occurring in atfer4 mutants, is responsible for an altered Fe homeostasis resulting in a change of intraorganellar Fe trafficking.	Iron	58-60	ferritin 4	Arabidopsis thaliana	248-254
20724023-7	2010	We propose that the complex molecular network maintaining Fe cellular homeostasis requires, in Arabidopsis heterotrophic cells, a proper balance of the different ferritin isoforms, and that alteration of this equilibrium, such as that occurring in atfer4 mutants, is responsible for an altered Fe homeostasis resulting in a change of intraorganellar Fe trafficking.	Iron	294-296	ferritin 4	Arabidopsis thaliana	248-254
20724023-7	2010	We propose that the complex molecular network maintaining Fe cellular homeostasis requires, in Arabidopsis heterotrophic cells, a proper balance of the different ferritin isoforms, and that alteration of this equilibrium, such as that occurring in atfer4 mutants, is responsible for an altered Fe homeostasis resulting in a change of intraorganellar Fe trafficking.	Iron	294-296	ferritin 4	Arabidopsis thaliana	248-254
17911100-9	2007	Iron-mediated oxidation resulted in the inhibition of both WRN helicase and exonuclease activities.	Iron	0-4	WRN RecQ like helicase	Homo sapiens	59-62
20889968-0	2010	Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assembly.	Iron	102-106	frataxin	Homo sapiens	65-73
17911100-13	2007	Therefore, our results demonstrate that WRN undergoes metal-catalyzed oxidation in the presence of iron, and iron-mediated oxidation of WRN likely results in the accumulation of a catalytically inactive form of the protein, which may contribute to age-related phenotypes.	Iron	99-103	WRN RecQ like helicase	Homo sapiens	40-43
17911100-13	2007	Therefore, our results demonstrate that WRN undergoes metal-catalyzed oxidation in the presence of iron, and iron-mediated oxidation of WRN likely results in the accumulation of a catalytically inactive form of the protein, which may contribute to age-related phenotypes.	Iron	109-113	WRN RecQ like helicase	Homo sapiens	136-139
20889968-1	2010	Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression of frataxin (FXN), a mitochondrial iron-binding protein required for Fe-S cluster assembly.	Iron	141-145	frataxin	Homo sapiens	109-117
20889968-1	2010	Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression of frataxin (FXN), a mitochondrial iron-binding protein required for Fe-S cluster assembly.	Iron	141-145	frataxin	Homo sapiens	119-122
20889968-1	2010	Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression of frataxin (FXN), a mitochondrial iron-binding protein required for Fe-S cluster assembly.	Iron	175-179	frataxin	Homo sapiens	109-117
18053288-4	2007	Here we discuss how dysregulation of the IRP system can result from both iron-related and unrelated effectors and explain how this can have important pathological consequences in several human disorders.	Iron	73-77	Wnt family member 2	Homo sapiens	41-44
20889968-1	2010	Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression of frataxin (FXN), a mitochondrial iron-binding protein required for Fe-S cluster assembly.	Iron	175-179	frataxin	Homo sapiens	119-122
20889968-7	2010	A shorter N terminus correlates with monomeric configuration, labile iron binding, and dynamic contacts with components of the Fe-S cluster biosynthetic machinery, i.e. the sulfur donor complex NFS1 ISD11 and the scaffold ISCU.	Iron	127-129	NFS1 cysteine desulfurase	Homo sapiens	194-198
20880065-0	2010	Restriction of calorie and iron intake results in reduction of visceral fat and serum alanine aminotransferase and ferritin levels in patients with chronic liver disease.	Iron	27-31	glutamic--pyruvic transaminase	Homo sapiens	86-110
17724144-0	2007	Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis.	Iron	34-38	homeostatic iron regulator	Homo sapiens	52-55
17724144-1	2007	Inadequate hepcidin synthesis leads to iron overload in HFE-related hemochromatosis.	Iron	39-43	homeostatic iron regulator	Homo sapiens	56-59
21348241-5	2010	The amount of cellular iron is regulated by the IRE (iron responsive element) and IRP (iron regulatory protein) system.	Iron	23-27	Wnt family member 2	Homo sapiens	82-85
17724144-9	2007	The hepcidin response to oral iron is blunted in HFE-related hemochromatosis and not improved after iron depletion.	Iron	30-34	homeostatic iron regulator	Homo sapiens	49-52
17724144-10	2007	The findings support the involvement of HFE in iron sensing and subsequent regulation of hepcidin.	Iron	47-51	homeostatic iron regulator	Homo sapiens	40-43
21348241-5	2010	The amount of cellular iron is regulated by the IRE (iron responsive element) and IRP (iron regulatory protein) system.	Iron	23-27	Wnt family member 2	Homo sapiens	87-110
20738258-0	2010	Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.	Iron	107-111	mitogen-activated protein kinase 14	Mus musculus	34-42
17763462-12	2007	The iron-induced increase in DNA-binding activity of the transcription factor CCAAT/enhancer binding protein alpha (C/EBP alpha) was also suppressed by alcohol.	Iron	4-8	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	78-114
17763462-12	2007	The iron-induced increase in DNA-binding activity of the transcription factor CCAAT/enhancer binding protein alpha (C/EBP alpha) was also suppressed by alcohol.	Iron	4-8	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	116-127
17763462-13	2007	CONCLUSION: Alcohol abolishes the iron-induced up-regulation of both liver hepcidin transcription and the DNA-binding activity of C/EBP alpha.	Iron	34-38	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	130-141
20738258-7	2010	In contrast, treatment of MEL cells with the p38 MAPK pathway inhibitor SB202190 had the opposite effect, resulting in decreased globin expression, haem synthesis and iron uptake.	Iron	167-171	mitogen-activated protein kinase 14	Mus musculus	45-53
20873749-0	2010	Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex.	Iron	58-62	frataxin	Homo sapiens	6-14
17889392-7	2007	Among them, 71 genes involved in iron uptake were significantly down-regulated in the absence of PA2384.	Iron	33-37	hypothetical protein	Pseudomonas aeruginosa PAO1	97-103
18025230-5	2007	Fe chelation inhibits TNF-driven transcription of Vcam-1, Icam-1, and E-selectin, as assessed using luciferase reporter assays.	Iron	0-2	intercellular adhesion molecule 1	Mus musculus	58-64
18363860-1	2008	The gene, BTBD9, was recently linked to restless legs syndrome, periodic limb movements and iron status in humans.	Iron	92-96	BTB domain containing 9	Homo sapiens	10-15
20873749-2	2010	Most researchers agree that frataxin functions in the biogenesis of Fe-S clusters, but its precise role in this process is unclear.	Iron	68-72	frataxin	Homo sapiens	28-36
20873749-3	2010	Here we provide in vitro evidence that human frataxin binds to a Nfs1, Isd11, and Isu2 complex to generate the four-component core machinery for Fe-S cluster biosynthesis.	Iron	145-149	frataxin	Homo sapiens	45-53
20873749-3	2010	Here we provide in vitro evidence that human frataxin binds to a Nfs1, Isd11, and Isu2 complex to generate the four-component core machinery for Fe-S cluster biosynthesis.	Iron	145-149	NFS1 cysteine desulfurase	Homo sapiens	65-69
20873749-6	2010	Together, these results indicate human frataxin functions with Fe(2+) as an allosteric activator that triggers sulfur delivery and Fe-S cluster assembly.	Iron	131-135	frataxin	Homo sapiens	39-47
17892445-6	2007	On the other hand, exogenous application of the NO donor S-nitrosoglutathione enhanced the accumulation of FER, LeFRO1 and LeIRT1 mRNA in roots of iron-deficient plants.	Iron	147-151	ferric-chelate reductase	Solanum lycopersicum	112-118
20873749-7	2010	We propose a model in which cellular frataxin levels regulate human Fe-S cluster biosynthesis that has implications for mitochondrial dysfunction, oxidative stress response, and both neurodegenerative and cardiovascular disease.	Iron	68-72	frataxin	Homo sapiens	37-45
20853438-0	2010	Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA).	Iron	69-73	fatty acid 2-hydroxylase	Homo sapiens	10-14
17597094-1	2007	Friedreich ataxia, the most common recessive ataxia, is caused by the deficiency of the mitochondrial protein frataxin (Fxn), an iron chaperone involved in the assembly of Fe-S clusters (ISC).	Iron	129-133	frataxin	Homo sapiens	110-118
18479124-4	2008	The eta2 version of this same species is less stable by 23.7 kcal/mol, which shows that the loss of one P--&gt; Fe bond is caused by dimerization, and therefore, it does not precede and cause dimerization.	Iron	112-114	DNA polymerase iota	Homo sapiens	4-8
20813430-7	2010	On the other hand, when APAP, A and B were docked on CYP2B1, their hydroxyl group was located near the heme iron on the snapshot at 3.5 ns.	Iron	108-112	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	53-59
18518943-2	2008	We focus here on the SOD family that uses Fe or Mn as cofactor.	Iron	42-44	superoxide dismutase 2	Homo sapiens	21-24
17597094-1	2007	Friedreich ataxia, the most common recessive ataxia, is caused by the deficiency of the mitochondrial protein frataxin (Fxn), an iron chaperone involved in the assembly of Fe-S clusters (ISC).	Iron	129-133	frataxin	Homo sapiens	120-123
17597094-1	2007	Friedreich ataxia, the most common recessive ataxia, is caused by the deficiency of the mitochondrial protein frataxin (Fxn), an iron chaperone involved in the assembly of Fe-S clusters (ISC).	Iron	172-176	frataxin	Homo sapiens	110-118
17597094-1	2007	Friedreich ataxia, the most common recessive ataxia, is caused by the deficiency of the mitochondrial protein frataxin (Fxn), an iron chaperone involved in the assembly of Fe-S clusters (ISC).	Iron	172-176	frataxin	Homo sapiens	120-123
18025284-3	2007	In addition, anti-hTfR IgG3-Av alone exhibits intrinsic cytotoxic activity and interferes with hTfR recycling, leading to the rapid degradation of the TfR and lethal iron deprivation in certain malignant B-cell lines.	Iron	166-170	transferrin receptor	Homo sapiens	19-22
20711621-1	2010	His349 in human transferrin (hTF) is a residue critical to transferrin receptor (TFR)-stimulated iron release from the C-lobe.	Iron	97-101	transferrin receptor	Homo sapiens	59-79
17512112-5	2007	From the results chemical coagulation, maximum COD reduction of about 81.3% was obtained at 300 mg/l of coagulant whereas in electrocoagulation process, maximum COD removal of about 92.31% (0.25 A/dm2) was achieved with energy consumption of about 19.29 k Wh/kg of COD and 80% (1A/dm(2)) COD removal was obtained with energy consumption of about 130.095 k Wh/kg of COD at iron and aluminum electrodes, respectively.	Iron	372-376	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	47-50
18485875-4	2008	Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions.	Iron	100-104	granzyme A	Homo sapiens	18-22
20711621-1	2010	His349 in human transferrin (hTF) is a residue critical to transferrin receptor (TFR)-stimulated iron release from the C-lobe.	Iron	97-101	transferrin receptor	Homo sapiens	81-84
18296681-1	2008	Iron overload may increase prostate cancer risk through stimulation of oxidative stress, and endogenous pro- and antioxidant capabilities, i.e. manganese superoxide dismutase (MnSOD) and myeloperoxidase (MPO), may modify these associations.	Iron	0-4	superoxide dismutase 2	Homo sapiens	144-174
18296681-1	2008	Iron overload may increase prostate cancer risk through stimulation of oxidative stress, and endogenous pro- and antioxidant capabilities, i.e. manganese superoxide dismutase (MnSOD) and myeloperoxidase (MPO), may modify these associations.	Iron	0-4	superoxide dismutase 2	Homo sapiens	176-181
17512112-5	2007	From the results chemical coagulation, maximum COD reduction of about 81.3% was obtained at 300 mg/l of coagulant whereas in electrocoagulation process, maximum COD removal of about 92.31% (0.25 A/dm2) was achieved with energy consumption of about 19.29 k Wh/kg of COD and 80% (1A/dm(2)) COD removal was obtained with energy consumption of about 130.095 k Wh/kg of COD at iron and aluminum electrodes, respectively.	Iron	372-376	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	161-164
17512112-5	2007	From the results chemical coagulation, maximum COD reduction of about 81.3% was obtained at 300 mg/l of coagulant whereas in electrocoagulation process, maximum COD removal of about 92.31% (0.25 A/dm2) was achieved with energy consumption of about 19.29 k Wh/kg of COD and 80% (1A/dm(2)) COD removal was obtained with energy consumption of about 130.095 k Wh/kg of COD at iron and aluminum electrodes, respectively.	Iron	372-376	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	161-164
17512112-5	2007	From the results chemical coagulation, maximum COD reduction of about 81.3% was obtained at 300 mg/l of coagulant whereas in electrocoagulation process, maximum COD removal of about 92.31% (0.25 A/dm2) was achieved with energy consumption of about 19.29 k Wh/kg of COD and 80% (1A/dm(2)) COD removal was obtained with energy consumption of about 130.095 k Wh/kg of COD at iron and aluminum electrodes, respectively.	Iron	372-376	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	161-164
17512112-5	2007	From the results chemical coagulation, maximum COD reduction of about 81.3% was obtained at 300 mg/l of coagulant whereas in electrocoagulation process, maximum COD removal of about 92.31% (0.25 A/dm2) was achieved with energy consumption of about 19.29 k Wh/kg of COD and 80% (1A/dm(2)) COD removal was obtained with energy consumption of about 130.095 k Wh/kg of COD at iron and aluminum electrodes, respectively.	Iron	372-376	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	161-164
20711621-4	2010	Significantly, all mutant/TFR complexes feature dampened iron release rates.	Iron	57-61	transferrin receptor	Homo sapiens	26-29
17854712-7	2007	We also report that AA increased the levels of intracellular catalytic iron and concomitantly modulated the expression of two well-established iron-regulated genes, ferritin and transferrin receptor.	Iron	143-147	transferrin receptor	Homo sapiens	178-198
18367482-4	2008	Importantly, heme-regulated eIF2alpha kinase deficiency exacerbates decreases in hepcidin expression and splenic macrophage iron in HFE(-)(/)(-) mice.	Iron	124-128	eukaryotic translation initiation factor 2A	Mus musculus	28-37
20711621-7	2010	By contrast, the H349A mutant/TFR complex releases iron at higher pH with a profile that is almost the inverse of that of the control complex.	Iron	51-55	transferrin receptor	Homo sapiens	30-33
20711621-8	2010	At the putative endosomal pH of 5.6 (in the presence of salt and chelator), iron is released from the H349W mutant/TFR and H349Y mutant/TFR complexes with a single rate constant similar to the iron release rate constant for the control; this suggests that these substitutions bypass the required pH-induced conformational change allowing the C-lobe to directly interact with the TFR to release iron.	Iron	76-80	transferrin receptor	Homo sapiens	115-118
18393371-2	2008	Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated).	Iron	38-42	transferrin receptor	Mus musculus	47-75
20711621-8	2010	At the putative endosomal pH of 5.6 (in the presence of salt and chelator), iron is released from the H349W mutant/TFR and H349Y mutant/TFR complexes with a single rate constant similar to the iron release rate constant for the control; this suggests that these substitutions bypass the required pH-induced conformational change allowing the C-lobe to directly interact with the TFR to release iron.	Iron	76-80	transferrin receptor	Homo sapiens	136-139
18393371-2	2008	Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated).	Iron	38-42	transferrin receptor	Mus musculus	80-84
18393371-6	2008	Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression.	Iron	14-18	transferrin receptor	Mus musculus	0-4
17847004-10	2007	This first reported association between common variants in the BMP pathway and iron burden suggests that full expression of HFE hemochromatosis is linked to abnormal liver expression of hepcidin, not only through impairment in the HFE function but also through functional modulation in the BMP pathway.	Iron	79-83	homeostatic iron regulator	Homo sapiens	124-127
18393371-6	2008	Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression.	Iron	113-117	transferrin receptor	Mus musculus	0-4
20711621-8	2010	At the putative endosomal pH of 5.6 (in the presence of salt and chelator), iron is released from the H349W mutant/TFR and H349Y mutant/TFR complexes with a single rate constant similar to the iron release rate constant for the control; this suggests that these substitutions bypass the required pH-induced conformational change allowing the C-lobe to directly interact with the TFR to release iron.	Iron	76-80	transferrin receptor	Homo sapiens	136-139
18393371-6	2008	Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression.	Iron	113-117	transferrin receptor	Mus musculus	0-4
18393371-7	2008	Iron and transferrin uptake by the Tfr1-independent pathway was approximately 100-fold greater than by the Tfr1 pathway and was not affected by the absence of Hfe.	Iron	0-4	transferrin receptor	Mus musculus	35-39
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	65-69
18393371-7	2008	Iron and transferrin uptake by the Tfr1-independent pathway was approximately 100-fold greater than by the Tfr1 pathway and was not affected by the absence of Hfe.	Iron	0-4	transferrin receptor	Mus musculus	107-111
20711621-11	2010	Thus, histidine uniquely drives the pH-induced conformational change in the C-lobe required for TFR interaction, which in turn promotes iron release.	Iron	136-140	transferrin receptor	Homo sapiens	96-99
18393371-9	2008	CONCLUSION: Tfr1-mediated iron uptake is regulated by Hfe in hepatocytes.	Iron	26-30	transferrin receptor	Mus musculus	12-16
20558735-2	2010	Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical IREs controls iron-dependent translation of the ferritin subunits.	Iron	105-109	aconitase 1	Homo sapiens	61-65
18393371-10	2008	The Tfr1-independent pathway exhibited a much greater capacity for iron uptake than the Tfr1 pathway but it was not regulated by Hfe.	Iron	67-71	transferrin receptor	Mus musculus	4-8
17886335-2	2007	The term hemochromatosis should refer to a unique clinicopathologic subset of iron-overload syndromes that currently includes the disorder related to the C282Y homozygote mutation of the hemochromatosis protein HFE (by far the most common form of hemochromatosis) and the rare disorders more recently attributed to the loss of transferrin receptor 2, HAMP (hepcidin antimicrobial peptide), or hemojuvelin or to certain ferroportin mutations.	Iron	78-82	homeostatic iron regulator	Homo sapiens	211-214
20558735-10	2010	Intracellular iron chelation increased binding of IRP1 to the APP IRE, decreasing intracellular APP expression in SH-SY5Y cells.	Iron	14-18	aconitase 1	Homo sapiens	50-54
21230928-1	2010	We discovered that under pressure SnO with alpha-PbO structure, the same structure as in many Fe-based superconductors, e.g., beta-FeSe, undergoes a transition to a superconducting state for p 6 GPa with a maximum Tc of 1.4 K at p=9.3 GPa.	Iron	94-96	strawberry notch homolog 1	Homo sapiens	34-37
17681937-0	2007	The metalloreductase Fre6p in Fe-efflux from the yeast vacuole.	Iron	30-32	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	21-26
17681937-5	2007	Using a combination of flameless atomic absorption spectrophotometry to quantify vacuolar and whole cell iron content and a reporter assay for cytoplasmic iron we demonstrate that Fre6p supplies Fe(II) to both efflux systems, while Fre7p plays no role in Fe-efflux from the vacuole.	Iron	105-109	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	180-185
17681937-5	2007	Using a combination of flameless atomic absorption spectrophotometry to quantify vacuolar and whole cell iron content and a reporter assay for cytoplasmic iron we demonstrate that Fre6p supplies Fe(II) to both efflux systems, while Fre7p plays no role in Fe-efflux from the vacuole.	Iron	155-159	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	180-185
17681937-5	2007	Using a combination of flameless atomic absorption spectrophotometry to quantify vacuolar and whole cell iron content and a reporter assay for cytoplasmic iron we demonstrate that Fre6p supplies Fe(II) to both efflux systems, while Fre7p plays no role in Fe-efflux from the vacuole.	Iron	195-197	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	180-185
18705322-0	2008	Could iron deposits in hepatocytes serve as a prognostic marker of HFE gene mutations?	Iron	6-10	homeostatic iron regulator	Homo sapiens	67-70
18705322-2	2008	The aim of this study was to evaluate the correlation between the presence of iron deposits in the liver and the HFE gene mutations in patients with chronic liver diseases (CLD).	Iron	78-82	homeostatic iron regulator	Homo sapiens	113-116
18705322-9	2008	CONCLUSIONS: The finding of iron deposits in routinely obtained liver specimen correlates with occurrence of the different HFE gene mutations.	Iron	28-32	homeostatic iron regulator	Homo sapiens	123-126
18270200-0	2008	A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis.	Iron	39-43	cytosolic iron-sulfur assembly component 3	Homo sapiens	11-15
18270200-5	2008	We examined IOP1 for a potential role in mammalian cytosolic Fe-S protein biogenesis.	Iron	61-65	cytosolic iron-sulfur assembly component 3	Homo sapiens	12-16
18270200-9	2008	Upon loss of its Fe-S cluster, cytosolic aconitase is known to be converted to iron regulatory protein 1, and consistent with this, we found that IOP1 knockdown increases transferrin receptor 1 mRNA levels and decreases ferritin heavy chain protein levels.	Iron	17-21	aconitase 1	Homo sapiens	79-104
18270200-9	2008	Upon loss of its Fe-S cluster, cytosolic aconitase is known to be converted to iron regulatory protein 1, and consistent with this, we found that IOP1 knockdown increases transferrin receptor 1 mRNA levels and decreases ferritin heavy chain protein levels.	Iron	17-21	cytosolic iron-sulfur assembly component 3	Homo sapiens	146-150
17729389-0	2007	HFE gene in primary and secondary hepatic iron overload.	Iron	42-46	homeostatic iron regulator	Homo sapiens	0-3
17729389-6	2007	In this article, we summarise current concepts regarding the cellular role of the HFE protein in iron homeostasis.	Iron	97-101	homeostatic iron regulator	Homo sapiens	82-85
18270200-10	2008	IOP1 knockdown also leads to a decrease in activity of xanthine oxidase, a distinct cytosolic Fe-S protein.	Iron	94-98	cytosolic iron-sulfur assembly component 3	Homo sapiens	0-4
21230928-3	2010	It is further shown from band structure calculations that SnO under pressure exhibits a Fermi surface topology similar to that reported for some Fe-based superconductors and that the nesting between the hole and electron pockets correlates with the change of Tc as a function of pressure.	Iron	88-90	strawberry notch homolog 1	Homo sapiens	58-61
18270200-11	2008	Taken together, these results provide evidence that IOP1 is involved in mammalian cytosolic Fe-S protein maturation.	Iron	92-96	cytosolic iron-sulfur assembly component 3	Homo sapiens	52-56
17729390-1	2007	Non-HFE hereditary haemochromatosis (HH) refers to a genetically heterogeneous group of iron overload disorders that are unlinked to mutations in the HFE gene.	Iron	88-92	homeostatic iron regulator	Homo sapiens	4-7
20737065-5	2010	Electrochemical studies showed that, in [ML](PF(6))(2) (M = Pd and Pt), the half-wave potential of the 1,1"-ferrocenediyl group shifts to much more positive potentials due to the strong through-space interaction between the two metals (M...Fe).	Iron	240-242	sperm associated antigen 17	Homo sapiens	45-50
17540841-0	2007	Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.	Iron	0-4	bone morphogenetic protein 2	Homo sapiens	100-106
18276042-2	2008	We determined whether the rise in post-prandial serum iron is increased in fully treated patients with hereditary haemochromatosis (HFE C282Y+/+; HH) compared to iron deficiency anaemia (IDA), iron-replete heterozygous subjects (HFE C282Y+/-) and iron-replete controls (HFE C282Y-/-).	Iron	54-58	homeostatic iron regulator	Homo sapiens	132-135
20555268-0	2010	The H63D genetic variant of the HFE gene is independently associated with the virological response to interferon and ribavirin therapy in chronic hepatitis C. BACKGROUND: Conflicting results have been reported in studies evaluating the relationship between serum markers of iron overload, liver iron deposits, and HFE mutations (C282Y and H63D) in chronic hepatitis C patients, and also their impact on the response to therapy in these patients.	Iron	274-278	homeostatic iron regulator	Homo sapiens	32-35
18278581-0	2008	VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation.	Iron	99-103	voltage dependent anion channel 2	Homo sapiens	0-5
18278581-0	2008	VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation.	Iron	99-103	aldolase, fructose-bisphosphate A	Homo sapiens	10-20
18278581-6	2008	The upregulation of aldolase A and VDAC2 in K562 cells under iron deprivation was also confirmed by western blot analysis.	Iron	61-65	aldolase, fructose-bisphosphate A	Homo sapiens	20-30
18278581-6	2008	The upregulation of aldolase A and VDAC2 in K562 cells under iron deprivation was also confirmed by western blot analysis.	Iron	61-65	voltage dependent anion channel 2	Homo sapiens	35-40
17705402-6	2007	Dynamic docking of terfenadone derivatives in the CYP2J2 active site allowed one to interpret the unexpected regioselectivity of the hydroxylation of these substrates by CYP2J2, which is mainly based on this restricted access to the iron.	Iron	233-237	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	50-56
17705402-6	2007	Dynamic docking of terfenadone derivatives in the CYP2J2 active site allowed one to interpret the unexpected regioselectivity of the hydroxylation of these substrates by CYP2J2, which is mainly based on this restricted access to the iron.	Iron	233-237	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	170-176
18278581-7	2008	This is the first time when the control of aldolase A and VDAC2 levels by iron status of the cell is demonstrated.	Iron	74-78	aldolase, fructose-bisphosphate A	Homo sapiens	43-53
20555268-0	2010	The H63D genetic variant of the HFE gene is independently associated with the virological response to interferon and ribavirin therapy in chronic hepatitis C. BACKGROUND: Conflicting results have been reported in studies evaluating the relationship between serum markers of iron overload, liver iron deposits, and HFE mutations (C282Y and H63D) in chronic hepatitis C patients, and also their impact on the response to therapy in these patients.	Iron	295-299	homeostatic iron regulator	Homo sapiens	32-35
18278581-7	2008	This is the first time when the control of aldolase A and VDAC2 levels by iron status of the cell is demonstrated.	Iron	74-78	voltage dependent anion channel 2	Homo sapiens	58-63
20555268-6	2010	HFE mutation was more frequent in patients with iron deposits, but without association with serum iron biochemistry or severity of liver disease.	Iron	48-52	homeostatic iron regulator	Homo sapiens	0-3
20658468-7	2010	Hepatic expression of BMP/Smad-related genes was examined in 20 HFE-HH males with significant iron overload, and compared to seven male HFE wild-type controls using quantitative real-time reverse transcription polymerase chain reaction.	Iron	94-98	SMAD family member 1	Homo sapiens	26-30
18332264-7	2008	Histology (at 3 weeks) revealed the presence of iron-containing macrophages at the injection site, identified by CD68 staining, but very few or no beta-galactosidase-positive stem cells in the animals transplanted with syngeneic or xenogeneic cells, respectively.	Iron	48-52	Cd68 molecule	Rattus norvegicus	113-117
18076961-5	2008	DMT1 mRNA expression in the small intestine of Fe-deficient WT mice was clearly increased compared to that in Fe-sufficient WT mice.	Iron	47-49	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
18076961-7	2008	The mk/mk mice have a mutation in DMT1 and loss of its function led to decreased intestinal Fe concentration.	Iron	92-94	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	34-38
20658468-8	2010	Hepatic expression of BMP6 was appropriately elevated in HFE-HH compared to controls (P = 0.02), likely related to iron overload.	Iron	115-119	homeostatic iron regulator	Homo sapiens	57-60
20806922-1	2010	The least understood mechanism during heme degradation by the enzyme heme oxygenase (HO) is the third step of ring opening of verdoheme to biliverdin, a process which maintains iron homeostasis.	Iron	177-181	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	69-83
18245813-4	2008	Up-regulation of insulin receptor by deferoxamine was mimicked by the intracellular iron chelator deferasirox and the hypoxia inducer CoCl2 and required the HIF-1 obligate partner ARNT/HIF-1beta.	Iron	84-88	insulin receptor	Rattus norvegicus	17-33
18245813-5	2008	Iron depletion increased insulin receptor activity, whereas iron supplementation had the opposite effect.	Iron	0-4	insulin receptor	Rattus norvegicus	25-41
20571030-4	2010	Furthermore, HbpS has been shown to modulate the phosphorylation state of the sensor kinase SenS as, in the absence of oxidative stress conditions, HbpS inhibits SenS autophosphorylation whereas the presence of heme or iron ions and redox-stressing agents enhances it.	Iron	219-223	potassium channel tetramerization domain containing 1	Homo sapiens	92-96
18308681-0	2008	Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutations: response to Equitani et al.	Iron	89-93	homeostatic iron regulator	Homo sapiens	109-112
18073202-5	2008	The divalent metal transporter 1(+)iron-responsive element isoform mRNA was decreased during zinc deficiency-induced iron accumulation.	Iron	35-39	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	4-32
20571030-4	2010	Furthermore, HbpS has been shown to modulate the phosphorylation state of the sensor kinase SenS as, in the absence of oxidative stress conditions, HbpS inhibits SenS autophosphorylation whereas the presence of heme or iron ions and redox-stressing agents enhances it.	Iron	219-223	potassium channel tetramerization domain containing 1	Homo sapiens	162-166
20617313-4	2010	Major transcriptional responses were induced by allicin and included the following: first, Rpn4p-mediated responses involved in proteasome gene expression; second, the Rsc1p-mediated response involved in iron ion transporter activity; third, the Gcn4p-mediated response, also known as general amino acid control; finally, the Yap1p-, Msn2/4p-, Crz1p-, and Cin5p-mediated multiple stress response.	Iron	204-208	RSC subunit protein RSC1	Saccharomyces cerevisiae S288C	168-173
18225897-3	2008	Ti2HsTf (2 equiv) binds the transferrin receptor TfR1 with Kd1 = 6.3 +/- 0.4 nM and Kd2 = 410 +/- 150 nM, values that are the tightest yet measured for a metal other than iron but weaker than the corresponding ones for Fe2HsTf due to both slightly slower on rates and slightly faster off rates.	Iron	171-175	transferrin receptor	Homo sapiens	49-53
19925473-15	2010	CONCLUSIONS: Non-HFE-related cardiac iron overload can occur in advanced liver disease We therefore recommend screening for cardiac iron prior to liver transplantation.	Iron	37-41	homeostatic iron regulator	Homo sapiens	17-20
18094142-1	2008	Transferrin receptor 2 (TfR2), a homologue of transferrin receptor 1 (TfR1), is a key molecule involved in the regulation of iron homeostasis.	Iron	125-129	transferrin receptor	Homo sapiens	46-68
18094142-1	2008	Transferrin receptor 2 (TfR2), a homologue of transferrin receptor 1 (TfR1), is a key molecule involved in the regulation of iron homeostasis.	Iron	125-129	transferrin receptor	Homo sapiens	70-74
18160053-1	2008	Frataxin is a ubiquitous mitochondrial iron-binding protein involved in the biosynthesis of Fe/S clusters and heme.	Iron	39-43	frataxin	Homo sapiens	0-8
20502928-7	2010	Additionally, absorption, magnetic circular dichroism, and resonance Raman data collected at different temperatures reveal an intriguing temperature dependence of the iron spin state in the heme-HO-2 complex.	Iron	167-171	heme oxygenase 2	Homo sapiens	195-199
18160053-1	2008	Frataxin is a ubiquitous mitochondrial iron-binding protein involved in the biosynthesis of Fe/S clusters and heme.	Iron	92-94	frataxin	Homo sapiens	0-8
18160053-8	2008	These data indicate that frataxin has some roles in controlling the balance between different mitochondrial iron pools that are partially in common with those of mitochondrial ferritin.	Iron	108-112	frataxin	Homo sapiens	25-33
20573043-0	2010	The hydroxypyridinone iron chelator CP94 can enhance PpIX-induced PDT of cultured human glioma cells.	Iron	22-26	beaded filament structural protein 1	Homo sapiens	36-40
20573043-3	2010	This study analyzed the effects of ALA/MAL-induced PDT combined with the iron chelator 1, 2-diethyl-3-hydroxypyridin-4-one hydrochloride (CP94) on the accumulation of PpIX in human glioma cells in vitro.	Iron	73-77	beaded filament structural protein 1	Homo sapiens	138-142
20486179-2	2010	Soluble transferrin receptor (sTfR) is an alternative marker of iron utilization.	Iron	64-68	transferrin receptor	Homo sapiens	8-28
20633248-1	2010	BACKGROUND: Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth.	Iron	96-100	lipocalin 2	Mus musculus	12-23
20633248-12	2010	The protective effect against E. coli infection in wild type mice could be counteracted by the siderophore ferrichrome, indicating that the protective effect of lipocalin 2 depends on its ability to sequester iron.	Iron	209-213	lipocalin 2	Mus musculus	161-172
20388835-11	2010	We also found that genes for caspases 3 and 12, which mediate endoplasmic reticulum (ER)-specific apoptosis, were upregulated in the iron-deficient group.	Iron	133-137	caspase 3	Rattus norvegicus	29-46
20339857-15	2010	Sural nerves in FRDA showed no convincing change in ferritin and ferroportin, militating against local iron dysmetabolism.	Iron	103-107	frataxin	Homo sapiens	16-20
20439772-5	2010	Surprisingly, only a subset of mutants identified are sensitive to extracellular iron fluctuations or display genetic interactions with mutants of iron regulon genes AFT2 or FET3.	Iron	147-151	ferroxidase FET3	Saccharomyces cerevisiae S288C	174-178
20825021-1	2010	Mixed plumes contained chlorinated solvents and petroleum hydrocarbons which mainly refers to BTEX (benzene, toluene, ethylbenzene and xylenes) in groundwater can be remediated by sequential units combined an iron permeable reactive barrier (Fe0-PRB) with an anoxic wall.	Iron	209-213	RB transcriptional corepressor 1	Homo sapiens	246-249
20825021-2	2010	In design of the Fe0-PRB it should be taken into account the necessity of altering the width of the iron cell in the presence of BTEX.	Iron	100-104	RB transcriptional corepressor 1	Homo sapiens	21-24
20309841-9	2010	The three-way ANOVA showed that the changes in LPO induced by in vitro treatment of kidney supernatants with exogenous Fe or V or Mg (600, 800 and 1000 microm) were a consequence of independent action of those metals and they also resulted from the interactions between exogenous Fe (Fe(exog)) and endogenous V (V(end)) and between V(end) and exogenous V (V(exog)).	Iron	119-121	lactoperoxidase	Rattus norvegicus	47-50
17592720-1	2007	The ferroxidase Fet3 and the permease Ftr1 constitute a well-conserved high-affinity iron uptake system in yeast.	Iron	85-89	ferroxidase FET3	Saccharomyces cerevisiae S288C	4-20
17592720-3	2007	Isolation and functional analysis of the Fet3 promoter indicate that a GATA sequence element plays a role in iron-dependent expression of Fet3.	Iron	109-113	ferroxidase FET3	Saccharomyces cerevisiae S288C	41-45
17592720-3	2007	Isolation and functional analysis of the Fet3 promoter indicate that a GATA sequence element plays a role in iron-dependent expression of Fet3.	Iron	109-113	ferroxidase FET3	Saccharomyces cerevisiae S288C	138-142
20309841-9	2010	The three-way ANOVA showed that the changes in LPO induced by in vitro treatment of kidney supernatants with exogenous Fe or V or Mg (600, 800 and 1000 microm) were a consequence of independent action of those metals and they also resulted from the interactions between exogenous Fe (Fe(exog)) and endogenous V (V(end)) and between V(end) and exogenous V (V(exog)).	Iron	280-282	lactoperoxidase	Rattus norvegicus	47-50
20309841-9	2010	The three-way ANOVA showed that the changes in LPO induced by in vitro treatment of kidney supernatants with exogenous Fe or V or Mg (600, 800 and 1000 microm) were a consequence of independent action of those metals and they also resulted from the interactions between exogenous Fe (Fe(exog)) and endogenous V (V(end)) and between V(end) and exogenous V (V(exog)).	Iron	280-282	lactoperoxidase	Rattus norvegicus	47-50
20399759-2	2010	Cell culture studies have demonstrated that enhancing ferritin expression by targeting iron regulatory protein (IRP) binding activity reduces cellular vulnerability to iron and hemoglobin.	Iron	87-91	wingless-type MMTV integration site family, member 2	Mus musculus	112-115
17490902-7	2007	There were reports of 24 unrelated African-Americans and 15 unrelated Native Africans without HFE C282Y who had iron overload.	Iron	112-116	homeostatic iron regulator	Homo sapiens	94-97
20524812-1	2010	Hepatocellular carcinoma (HCC), following liver cirrhosis as a complication of chronic hepatitis B or C viruses (HBV or HCV)and iron overload, has been reported in thalassemia patients.	Iron	128-132	HCC	Homo sapiens	26-29
17586630-5	2007	Furthermore, the hurP mutant was unable to utilize hemin as a sole source of nutrient Fe.	Iron	86-88	DLG associated protein 5	Homo sapiens	17-21
20524812-4	2010	Three (33.3%) TI patients with liver siderosis and fibrosis and late introduction of iron chelation developed HCC without a history of hepatitis.	Iron	85-89	HCC	Homo sapiens	110-113
20524812-6	2010	The main risk factor for HCC was HCV infection in TM patients but it was iron activity in TI patients.	Iron	73-77	HCC	Homo sapiens	25-28
20420442-3	2010	Ca and Fe carbonates, crystalline and amorphous Fe sulfides, and Fe (hydr)oxides have precipitated in the granular ZVI material in the PRB.	Iron	115-118	RB transcriptional corepressor 1	Homo sapiens	135-138
17622274-10	2007	irons in the measured urine N-acetyl-beta-D-glucosaminidase/creatinine ratio.	Iron	0-5	O-GlcNAcase	Homo sapiens	28-59
20420442-6	2010	The ZVI filings in the down-gradient effluent section of the PRB have a projected life span of &gt;10 years compared with ZVI filings from the continuous to discontinuous cemented up-gradient ZVI section (upper approximately 25 cm) of the PRB, which may have a life span of only approximately 2-5 more years.	Iron	4-7	RB transcriptional corepressor 1	Homo sapiens	61-64
20420442-6	2010	The ZVI filings in the down-gradient effluent section of the PRB have a projected life span of &gt;10 years compared with ZVI filings from the continuous to discontinuous cemented up-gradient ZVI section (upper approximately 25 cm) of the PRB, which may have a life span of only approximately 2-5 more years.	Iron	4-7	RB transcriptional corepressor 1	Homo sapiens	239-242
17567949-5	2007	Moreover, limited depletion of iron from prion disease-affected human and mouse brain homogenates and scrapie-infected mouse neuroblastoma cells results in 4- to 10-fold reduction in proteinase K (PK)-resistant PrP(Sc), implicating redox iron in the generation, propagation, and stability of PK-resistant PrP(Sc).	Iron	31-35	prion protein	Mus musculus	211-214
20302851-7	2010	By co-overloading of Cu and Fe, Cu-overload-related single liver cell toxicity and regeneration increased, as did cytokine imbalances involving increased cyclooxygenase-2-producing Kupffer cells and accumulation of malondialdehyde within GST-P(+) foci.	Iron	28-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	154-170
17567949-5	2007	Moreover, limited depletion of iron from prion disease-affected human and mouse brain homogenates and scrapie-infected mouse neuroblastoma cells results in 4- to 10-fold reduction in proteinase K (PK)-resistant PrP(Sc), implicating redox iron in the generation, propagation, and stability of PK-resistant PrP(Sc).	Iron	31-35	prion protein	Mus musculus	305-308
20404192-1	2010	The primary route of iron acquisition in vertebrates is the transferrin receptor (TfR) mediated endocytotic pathway, which provides cellular entry to the metal transporter serum transferrin (Tf).	Iron	21-25	transferrin receptor	Homo sapiens	60-80
17590401-9	2007	Surprisingly, although mRNA levels for the HSPs were not altered by iron, the abundance of Hsp25, Hsp70 and Hsp90 proteins was uniformly reduced in the iron-loaded livers, as were levels of NAD(P)H:quinone oxidoreductase 1, an Hsp70 client protein.	Iron	152-156	heat shock protein family B (small) member 1	Rattus norvegicus	91-96
20404192-1	2010	The primary route of iron acquisition in vertebrates is the transferrin receptor (TfR) mediated endocytotic pathway, which provides cellular entry to the metal transporter serum transferrin (Tf).	Iron	21-25	transferrin receptor	Homo sapiens	82-85
20404192-7	2010	Iron-loaded Tf displaces apo-Tf from TfR, making it available for the next cycle of iron binding, transport and delivery to tissues.	Iron	0-4	transferrin receptor	Homo sapiens	37-40
17726528-3	2007	The transferrin receptor (TfR) is involved in iron uptake by internalization of transferrin and is over-expressed in rapidly growing tumors.	Iron	46-50	transferrin receptor	Homo sapiens	4-24
17726528-3	2007	The transferrin receptor (TfR) is involved in iron uptake by internalization of transferrin and is over-expressed in rapidly growing tumors.	Iron	46-50	transferrin receptor	Homo sapiens	26-29
20404192-7	2010	Iron-loaded Tf displaces apo-Tf from TfR, making it available for the next cycle of iron binding, transport and delivery to tissues.	Iron	84-88	transferrin receptor	Homo sapiens	37-40
17726528-4	2007	The ATP-binding cassette (ABC) transporters ABCB6 and ABCB7 are also involved in iron homeostasis.	Iron	81-85	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	4-24
17726528-4	2007	The ATP-binding cassette (ABC) transporters ABCB6 and ABCB7 are also involved in iron homeostasis.	Iron	81-85	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	26-29
17726528-4	2007	The ATP-binding cassette (ABC) transporters ABCB6 and ABCB7 are also involved in iron homeostasis.	Iron	81-85	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	44-49
17726528-15	2007	Several factors involved in iron homeostasis such as TfR and ABCB6 may contribute to this effect.	Iron	28-32	transferrin receptor	Homo sapiens	53-56
17726528-15	2007	Several factors involved in iron homeostasis such as TfR and ABCB6 may contribute to this effect.	Iron	28-32	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	61-66
20026081-0	2010	AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress.	Iron	102-106	glycogen synthase kinase 3 beta	Homo sapiens	14-22
17470359-7	2007	Inactivation of CYP2J2 by 13 is due to the formation of a stable iron-carbene bond which occurs upon CYP2J2-catalyzed oxidation of 13 with a partition ratio of 18+/-3.	Iron	65-69	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	16-22
17470359-7	2007	Inactivation of CYP2J2 by 13 is due to the formation of a stable iron-carbene bond which occurs upon CYP2J2-catalyzed oxidation of 13 with a partition ratio of 18+/-3.	Iron	65-69	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	101-107
20026081-8	2010	ILQ treatment enhanced inhibitory phosphorylation of glycogen synthase kinase-3beta (GSK3beta), and prevented a decrease in the GSK3beta phosphorylation elicited by AA+iron, which contributed to protecting cells and mitochondria.	Iron	168-172	glycogen synthase kinase 3 beta	Homo sapiens	128-136
20026081-10	2010	These results demonstrate that ILQ has the ability to protect cells from AA+iron-induced H2O2 production and mitochondrial dysfunction, which is mediated with GSK3beta phosphorylation downstream of AMPK.	Iron	76-80	glycogen synthase kinase 3 beta	Homo sapiens	159-167
20229093-0	2010	Functional characterization of iron-substituted neural zinc finger factor 1: metal and DNA binding.	Iron	31-35	myelin transcription factor 1 like	Homo sapiens	48-75
17635368-9	2007	These novel gene products interact with HFE in a common pathway for iron homeostasis.	Iron	68-72	homeostatic iron regulator	Homo sapiens	40-43
17635368-10	2007	CONCLUSIONS: Further identification of non-HFE genes associated with iron homeostasis will enhance our diagnostic certainty of primary haemochromatosis and may explain the variable expression seen in HFE-related disease.	Iron	69-73	homeostatic iron regulator	Homo sapiens	43-46
17635368-10	2007	CONCLUSIONS: Further identification of non-HFE genes associated with iron homeostasis will enhance our diagnostic certainty of primary haemochromatosis and may explain the variable expression seen in HFE-related disease.	Iron	69-73	homeostatic iron regulator	Homo sapiens	200-203
20208481-1	2010	Increased iron deposition is often seen in liver explants with alpha-1-antitrypsin deficiency, but it remains unclear if this is a nonspecific effect of end-stage liver disease or if individuals with alpha-1-antitrypsin deficiency and excess iron are at increased risk for HFE mutations.	Iron	10-14	homeostatic iron regulator	Homo sapiens	273-276
17521623-9	2007	CONCLUSIONS: The quantitative FCM method for TfR expression on reticulocytes was found to reflect iron status at the cellular level.	Iron	98-102	transferrin receptor	Homo sapiens	45-48
20208481-7	2010	However, there was a significant association with HFE mutations in alpha-1-antitrypsin deficiency livers with grade 3+ or 4+ iron, P=0.02.	Iron	125-129	homeostatic iron regulator	Homo sapiens	50-53
19823114-1	2010	After major skeletal muscle trauma, the iron-containing protein myoglobin and diverse other intracellular metabolites are liberated into the circulation from injured myocytes.	Iron	40-44	myoglobin	Rattus norvegicus	64-73
17517886-2	2007	Designated AtATM1, AtAATM2, and AtATM3, these half-molecule ABC proteins are homologous to the yeast mitochondrial membrane protein ATM1 (ScATM1), which is clearly implicated in the export of mitochondrially synthesized iron/sulfur clusters.	Iron	220-224	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	13-17
17517886-3	2007	Yeast ATM1-deficient (atm1) mutants grow very slowly (have a petite phenotype), are respiration-deficient, accumulate toxic levels of iron in their mitochondria, and show enhanced compensatory high affinity iron uptake.	Iron	134-138	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	22-26
17517886-3	2007	Yeast ATM1-deficient (atm1) mutants grow very slowly (have a petite phenotype), are respiration-deficient, accumulate toxic levels of iron in their mitochondria, and show enhanced compensatory high affinity iron uptake.	Iron	207-211	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	22-26
18076708-4	2008	First, Fe(NO) provides us with a practical tool to aid in the diagnosis of asthma and distinguish patients who will benefit from inhaled corticosteroids from those who will not.	Iron	7-9	activation induced cytidine deaminase	Homo sapiens	51-54
20385840-1	2010	The O(2) reduction site of cytochrome c oxidase (CcO), comprising iron (Fe(a3)) and copper (Cu(B)) ions, is probed by x-ray structural analyses of CO, NO, and CN(-) derivatives to investigate the mechanism of the complete reduction of O(2).	Iron	66-70	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	27-47
18261896-1	2008	Iron homeostasis in animal cells is controlled post-transcriptionally by the iron regulatory proteins IRP1 and IRP2.	Iron	0-4	aconitase 1	Homo sapiens	102-106
18261896-1	2008	Iron homeostasis in animal cells is controlled post-transcriptionally by the iron regulatory proteins IRP1 and IRP2.	Iron	77-81	aconitase 1	Homo sapiens	102-106
18261896-3	2008	During iron scarcity or oxidative stress, IRP1 binds to mRNA stem-loop structures called iron responsive elements (IREs) to modulate the translation of iron metabolism genes.	Iron	7-11	aconitase 1	Homo sapiens	42-46
18261896-3	2008	During iron scarcity or oxidative stress, IRP1 binds to mRNA stem-loop structures called iron responsive elements (IREs) to modulate the translation of iron metabolism genes.	Iron	89-93	aconitase 1	Homo sapiens	42-46
18261896-3	2008	During iron scarcity or oxidative stress, IRP1 binds to mRNA stem-loop structures called iron responsive elements (IREs) to modulate the translation of iron metabolism genes.	Iron	89-93	aconitase 1	Homo sapiens	42-46
18261896-4	2008	In iron-rich conditions, IRP1 binds an iron-sulfur cluster to function as a cytosolic aconitase.	Iron	3-7	aconitase 1	Homo sapiens	25-29
17517884-3	2007	Here, we show that exposure of cultured cells to sustained low levels of H(2)O(2) that mimic its release by inflammatory cells leads to up-regulation of transferrin receptor 1 (TfR1), the major iron uptake protein.	Iron	194-198	transferrin receptor	Homo sapiens	153-175
17517884-3	2007	Here, we show that exposure of cultured cells to sustained low levels of H(2)O(2) that mimic its release by inflammatory cells leads to up-regulation of transferrin receptor 1 (TfR1), the major iron uptake protein.	Iron	194-198	transferrin receptor	Homo sapiens	177-181
17517884-4	2007	The increase in TfR1 results in increased transferrin-mediated iron uptake and cellular accumulation of the metal.	Iron	63-67	transferrin receptor	Homo sapiens	16-20
17517884-8	2007	Our results suggest a novel mechanism of iron accumulation by sustained H(2)O(2), based on the translational activation of TfR1, which could provide an important (patho) physiological link between iron metabolism and inflammation.	Iron	41-45	transferrin receptor	Homo sapiens	123-127
17428702-1	2007	Liver is the primary target organ of Hereditary Hemochromatosis Type I, with the HFE mutations C282Y and H63D recognized as markers of this iron-overload disease.	Iron	140-144	homeostatic iron regulator	Homo sapiens	81-84
18261896-4	2008	In iron-rich conditions, IRP1 binds an iron-sulfur cluster to function as a cytosolic aconitase.	Iron	39-43	aconitase 1	Homo sapiens	25-29
18261896-5	2008	This functional duality of IRP1 connects the translational control of iron metabolizing proteins to cellular iron levels.	Iron	70-74	aconitase 1	Homo sapiens	27-31
18261896-5	2008	This functional duality of IRP1 connects the translational control of iron metabolizing proteins to cellular iron levels.	Iron	109-113	aconitase 1	Homo sapiens	27-31
18083798-9	2008	Third, reduced AtOPT3 expression resulted in decreased accumulation of iron in opt3-2 seeds.	Iron	71-75	oligopeptide transporter	Arabidopsis thaliana	15-21
18083798-9	2008	Third, reduced AtOPT3 expression resulted in decreased accumulation of iron in opt3-2 seeds.	Iron	71-75	oligopeptide transporter	Arabidopsis thaliana	79-83
20385840-1	2010	The O(2) reduction site of cytochrome c oxidase (CcO), comprising iron (Fe(a3)) and copper (Cu(B)) ions, is probed by x-ray structural analyses of CO, NO, and CN(-) derivatives to investigate the mechanism of the complete reduction of O(2).	Iron	66-70	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	49-52
18083798-10	2008	The reduced accumulation of iron in opt3-2 seeds is especially noteworthy considering the excessively high levels of accumulated iron in other opt3-2 tissues.	Iron	28-32	oligopeptide transporter	Arabidopsis thaliana	36-40
18083798-10	2008	The reduced accumulation of iron in opt3-2 seeds is especially noteworthy considering the excessively high levels of accumulated iron in other opt3-2 tissues.	Iron	28-32	oligopeptide transporter	Arabidopsis thaliana	143-147
17399844-6	2007	In addition, transferrin receptor 1 (TfR1) was also downregulated, while ferroportin levels were elevated, resulting in reduced iron uptake and increased iron release capacity of replicon cells.	Iron	128-132	transferrin receptor	Homo sapiens	13-35
17399844-6	2007	In addition, transferrin receptor 1 (TfR1) was also downregulated, while ferroportin levels were elevated, resulting in reduced iron uptake and increased iron release capacity of replicon cells.	Iron	128-132	transferrin receptor	Homo sapiens	37-41
17399844-6	2007	In addition, transferrin receptor 1 (TfR1) was also downregulated, while ferroportin levels were elevated, resulting in reduced iron uptake and increased iron release capacity of replicon cells.	Iron	154-158	transferrin receptor	Homo sapiens	13-35
18083798-10	2008	The reduced accumulation of iron in opt3-2 seeds is especially noteworthy considering the excessively high levels of accumulated iron in other opt3-2 tissues.	Iron	129-133	oligopeptide transporter	Arabidopsis thaliana	36-40
18083798-11	2008	AtOPT3, therefore, plays a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron homeostasis and iron nutrition of developing seeds.	Iron	69-73	oligopeptide transporter	Arabidopsis thaliana	0-6
20436681-2	2010	METHODS AND FINDINGS: In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism.	Iron	110-114	microRNA 210	Homo sapiens	76-83
18083798-11	2008	AtOPT3, therefore, plays a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron homeostasis and iron nutrition of developing seeds.	Iron	121-125	oligopeptide transporter	Arabidopsis thaliana	0-6
18083798-11	2008	AtOPT3, therefore, plays a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron homeostasis and iron nutrition of developing seeds.	Iron	121-125	oligopeptide transporter	Arabidopsis thaliana	0-6
18226225-0	2008	Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.	Iron	0-4	Wnt family member 2	Homo sapiens	30-33
17200797-1	2007	Iron regulatory proteins 1 and 2 (IRP1, IRP2) are key determinants of uptake and storage of iron by the liver, and are responsive to oxidative stress and hypoxia potentially at the level of both protein concentration and mRNA-binding activity.	Iron	92-96	aconitase 1	Homo sapiens	0-32
17200797-1	2007	Iron regulatory proteins 1 and 2 (IRP1, IRP2) are key determinants of uptake and storage of iron by the liver, and are responsive to oxidative stress and hypoxia potentially at the level of both protein concentration and mRNA-binding activity.	Iron	92-96	aconitase 1	Homo sapiens	34-38
20436681-2	2010	METHODS AND FINDINGS: In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism.	Iron	170-174	microRNA 210	Homo sapiens	76-83
18273820-2	2008	HFE is a gene with the polymorphisms C282Y and H63D, which are associated with a progressive iron accumulation in the organism leading to a disease called hereditary hemochromatosis.	Iron	93-97	homeostatic iron regulator	Homo sapiens	0-3
20436681-2	2010	METHODS AND FINDINGS: In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism.	Iron	170-174	microRNA 210	Homo sapiens	76-83
17490790-3	2007	The findings showed that peripheral iron dextran overload increased the iron staining positive cells and reduced the number of TH-immunoreactive neurons in the SN.	Iron	36-40	tyrosine hydroxylase	Rattus norvegicus	127-129
20436681-6	2010	CONCLUSIONS: Induction of these major hallmarks of cancer show that a single microRNA, miR-210, mediates a new mechanism of adaptation to hypoxia, by regulating mitochondrial function via iron-sulfur cluster metabolism and free radical generation.	Iron	188-192	microRNA 210	Homo sapiens	87-94
20413654-3	2010	Frataxin is a highly conserved protein, which has been suggested to participate in a variety of different roles associated with cellular iron homeostasis.	Iron	137-141	frataxin	Homo sapiens	0-8
17533620-6	2007	Finally, the other selected genes, ISU1, involved in the biosynthesis of the iron-sulphur cluster in mitochondria, and the less well functionally defined BSC5 and YBR270c, may participate in the cell"s antioxidant and stress defence.	Iron	77-81	Bsc5p	Saccharomyces cerevisiae S288C	154-158
18029358-0	2008	The iron-containing domain is essential in Rad3 helicases for coupling of ATP hydrolysis to DNA translocation and for targeting the helicase to the single-stranded DNA-double-stranded DNA junction.	Iron	4-8	helicase for meiosis 1	Homo sapiens	48-56
18024960-10	2008	These data demonstrate that the activation of ftn-1 and ftn-2 transcription by iron requires ELT-2 and that the IDE functions as an iron-dependent enhancer in intestine.	Iron	79-83	Transcription factor elt-2	Caenorhabditis elegans	93-98
19959254-4	2010	We show that ATFER4 is indeed localized in mitochondria of Fe-treated Arabidopsis plants; when grown under Fe excess, atfer4 plants manifest, however, the same toxicity symptoms and O(2) consumption rates as wt plants.	Iron	59-61	ferritin 4	Arabidopsis thaliana	13-19
18709494-10	2008	And, elevated IRP1 expression might be associated with the increased TfR and decreased ferritin expression, leading to subsequent iron accumulation and possible increased vulnerability to oxidative damage in hippocampus.	Iron	130-134	aconitase 1	Rattus norvegicus	14-18
18709494-10	2008	And, elevated IRP1 expression might be associated with the increased TfR and decreased ferritin expression, leading to subsequent iron accumulation and possible increased vulnerability to oxidative damage in hippocampus.	Iron	130-134	transferrin receptor	Rattus norvegicus	69-72
18712630-5	2008	While the liver is the predominant organ of iron deposition and iron-overload-related disease in HFE-related HH, involvement of extrahepatic tissue can also result in morbidity and mortality if the disorder is not diagnosed before organ damage develops.	Iron	64-68	homeostatic iron regulator	Homo sapiens	97-100
17553495-3	2007	IRP-like cytoplasmic proteins that bound human ferritin IRE sequence transcripts at low-iron conditions were also found in trichomonads.	Iron	88-92	Wnt family member 2	Homo sapiens	0-3
17553495-4	2007	Thus, a post-transcriptional regulatory mechanism by iron for tvcp4 mediated by IRE/IRP-like interactions was found.	Iron	53-57	Wnt family member 2	Homo sapiens	84-87
19959254-4	2010	We show that ATFER4 is indeed localized in mitochondria of Fe-treated Arabidopsis plants; when grown under Fe excess, atfer4 plants manifest, however, the same toxicity symptoms and O(2) consumption rates as wt plants.	Iron	59-61	ferritin 4	Arabidopsis thaliana	118-124
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	177-182
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	177-182
18045552-1	2008	HFE gene mutations are associated with over 80% of cases of hereditary hemochromatosis (HH), an iron-overload disease in which the liver is the most frequently affected organ.	Iron	96-100	homeostatic iron regulator	Homo sapiens	0-3
19959254-4	2010	We show that ATFER4 is indeed localized in mitochondria of Fe-treated Arabidopsis plants; when grown under Fe excess, atfer4 plants manifest, however, the same toxicity symptoms and O(2) consumption rates as wt plants.	Iron	107-109	ferritin 4	Arabidopsis thaliana	13-19
18045552-6	2008	The effect of HFE in iron import and oxidative stress levels was assessed.	Iron	21-25	homeostatic iron regulator	Homo sapiens	14-17
19959254-4	2010	We show that ATFER4 is indeed localized in mitochondria of Fe-treated Arabidopsis plants; when grown under Fe excess, atfer4 plants manifest, however, the same toxicity symptoms and O(2) consumption rates as wt plants.	Iron	107-109	ferritin 4	Arabidopsis thaliana	118-124
18195524-4	2008	Recent advances in the analyses of iron regulation in cells and animals reveal that the protein degradation system is involved in the iron-mediated regulation of another regulator of iron metabolism, IRP1.	Iron	35-39	aconitase 1	Homo sapiens	200-204
18195524-4	2008	Recent advances in the analyses of iron regulation in cells and animals reveal that the protein degradation system is involved in the iron-mediated regulation of another regulator of iron metabolism, IRP1.	Iron	134-138	aconitase 1	Homo sapiens	200-204
17533042-0	2007	Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation.	Iron	0-4	aconitase 1	Homo sapiens	5-10
19997770-5	2010	The iron depletion induced by ICL670 in differentiated cells increased soluble transferrin receptor expression, decreased intracellular ferritin expression, inhibited (55)Fe (III) uptake, and reduced the hepatocyte concentration of the labile iron pool.	Iron	4-8	transferrin receptor	Homo sapiens	79-99
17533042-0	2007	Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation.	Iron	0-4	transferrin receptor	Homo sapiens	55-75
17533042-7	2007	When cells were incubated with (59)FeCl(3), (59)Fe-bound IRP-1 immunoprecipitated with anti-IRP-1 antibodies was detected on first phase and third phase, but was not detected on second phase.	Iron	35-37	aconitase 1	Homo sapiens	57-62
17533042-7	2007	When cells were incubated with (59)FeCl(3), (59)Fe-bound IRP-1 immunoprecipitated with anti-IRP-1 antibodies was detected on first phase and third phase, but was not detected on second phase.	Iron	35-37	aconitase 1	Homo sapiens	92-97
17533042-8	2007	CONCLUSION: These results suggest that IRP-1/IRE interactions, which are supposedly induced after sensing a decrease of the intracellular non-Heme iron levels, play a crucial role on the posttranscriptional regulation of TfR, DMT1, and ferritin mRNAs during differentiation of normal human erythropoietic cells.	Iron	147-151	aconitase 1	Homo sapiens	39-44
17533042-8	2007	CONCLUSION: These results suggest that IRP-1/IRE interactions, which are supposedly induced after sensing a decrease of the intracellular non-Heme iron levels, play a crucial role on the posttranscriptional regulation of TfR, DMT1, and ferritin mRNAs during differentiation of normal human erythropoietic cells.	Iron	147-151	transferrin receptor	Homo sapiens	221-224
18195524-4	2008	Recent advances in the analyses of iron regulation in cells and animals reveal that the protein degradation system is involved in the iron-mediated regulation of another regulator of iron metabolism, IRP1.	Iron	134-138	aconitase 1	Homo sapiens	200-204
17689879-3	2008	I propose that hereditary hemochromatosis and in particular the common HFE C282Y mutation may represent an adaptation to decreased dietary iron in cereal grain-based Neolithic diets.	Iron	139-143	homeostatic iron regulator	Homo sapiens	71-74
17689879-4	2008	Both homozygous and heterozygous carriers of the HFE C282Y mutation have increased iron stores and therefore possessed an adaptive advantage under Neolithic conditions.	Iron	83-87	homeostatic iron regulator	Homo sapiens	49-52
20040761-0	2010	SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.	Iron	15-19	SMAD family member 7	Mus musculus	0-5
17689879-7	2008	The HFE C282Y mutation likely only became maladaptive in the past several centuries as dietary sources of iron and vitamin C improved in Northern Europe.	Iron	106-110	homeostatic iron regulator	Homo sapiens	4-7
17487432-9	2007	Thus we conclude that iron (II) sulphate is actually growth inhibitory and even cytotoxic at high concentrations towards the K562 and T47D cancer cells and the paradoxical proliferative activity of iron (II) sulphate on these two cancer cell lines using the MTS assay was solely due to the oxidation of initial pale green iron (II) to brownish iron (III) during incubation in the aqueous condition.	Iron	22-28	MLRL	Homo sapiens	258-261
17487432-9	2007	Thus we conclude that iron (II) sulphate is actually growth inhibitory and even cytotoxic at high concentrations towards the K562 and T47D cancer cells and the paradoxical proliferative activity of iron (II) sulphate on these two cancer cell lines using the MTS assay was solely due to the oxidation of initial pale green iron (II) to brownish iron (III) during incubation in the aqueous condition.	Iron	22-26	MLRL	Homo sapiens	258-261
17904763-1	2008	Hereditary hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele are at risk of developing liver disease, diabetes and arthritis.	Iron	69-73	homeostatic iron regulator	Homo sapiens	137-140
20040761-5	2010	SMAD7 is an inhibitory SMAD protein that mediates a negative feedback loop to both transforming growth factor-beta and BMP signaling and that recently was shown to be coregulated with hepcidin via SMAD4 in response to altered iron availability in vivo.	Iron	226-230	SMAD family member 7	Mus musculus	0-5
18026094-6	2008	In vivo, systemic challenge with iron rapidly induced SMAD1/5/8 phosphorylation and hepcidin expression in the liver, whereas treatment with dorsomorphin blocked SMAD1/5/8 phosphorylation, normalized hepcidin expression and increased serum iron levels.	Iron	33-37	SMAD family member 1	Danio rerio	54-61
17526834-0	2007	Cloning and characterization of the genes encoding the high-affinity iron-uptake protein complex Fet3/Ftr1 in the basidiomycete Phanerochaete chrysosporium.	Iron	69-73	ferroxidase FET3	Saccharomyces cerevisiae S288C	97-101
17526834-2	2007	This enzyme shows biochemical and structural similarities with the yeast Fet3p, a type I membrane glycoprotein that efficiently oxidizes Fe(II) to Fe(III) for its subsequent transport to the intracellular compartment by the iron permease Ftr1p.	Iron	224-228	ferroxidase FET3	Saccharomyces cerevisiae S288C	73-78
17526834-8	2007	Northern hybridization studies showed that the mRNA levels of both genes are reduced upon supplementation of the growth medium with iron, supporting the functional coupling of Fet3 and Ftr1 proteins in vivo.	Iron	132-136	ferroxidase FET3	Saccharomyces cerevisiae S288C	176-180
20346225-4	2010	In tumor cells, iron metabolism changes by several mechanisms, such as regulating the growth of tumor cells by transferrin, accelerating the uptake of iron by the overexpressions of transferrin receptors 1 and 2 (TfR1 and TfR2), synthesizing or secreting ferritin by some malignant tumor cells, and upregulating the level of hepcidin in patients with cancer.	Iron	16-20	transferrin receptor	Homo sapiens	213-217
17264297-2	2007	Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells.	Iron	237-241	transferrin receptor	Mus musculus	174-178
18154662-14	2007	To gain further insight into the iron physiological status of the plants, the root iron reductase activity was measured in both iron efficient and inefficient genotypes for plants grown under iron sufficient and iron limited conditions.	Iron	83-87	chalcone reductase CHR1	Glycine max	88-97
18154662-14	2007	To gain further insight into the iron physiological status of the plants, the root iron reductase activity was measured in both iron efficient and inefficient genotypes for plants grown under iron sufficient and iron limited conditions.	Iron	83-87	chalcone reductase CHR1	Glycine max	88-97
18154662-14	2007	To gain further insight into the iron physiological status of the plants, the root iron reductase activity was measured in both iron efficient and inefficient genotypes for plants grown under iron sufficient and iron limited conditions.	Iron	83-87	chalcone reductase CHR1	Glycine max	88-97
18154662-15	2007	Iron inefficient plants failed to respond to decreased iron availability with increased activity of Fe reductase.	Iron	0-4	chalcone reductase CHR1	Glycine max	103-112
18154662-18	2007	Root membrane bound reductase capacity is often correlated with iron efficiency.	Iron	64-68	chalcone reductase CHR1	Glycine max	20-29
17031680-2	2007	Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals.	Iron	120-122	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	24-52
17031680-2	2007	Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals.	Iron	120-122	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	54-58
18154662-19	2007	Under iron-limited conditions, the iron efficient plant had high root bound membrane reductase capacity while the iron inefficient plants reductase levels remained low, further limiting iron uptake through the root.	Iron	6-10	chalcone reductase CHR1	Glycine max	85-94
20346225-5	2010	Some advances on diagnosis and treatment based on iron metabolism have been achieved, such as increasing the transfection and target efficiency of transferrin-polyethylenimine (PEI), inducing cell apoptosis by beta-guttiferin through interacting with TfR1.	Iron	50-54	transferrin receptor	Homo sapiens	251-255
18154662-19	2007	Under iron-limited conditions, the iron efficient plant had high root bound membrane reductase capacity while the iron inefficient plants reductase levels remained low, further limiting iron uptake through the root.	Iron	35-39	chalcone reductase CHR1	Glycine max	85-94
18154662-19	2007	Under iron-limited conditions, the iron efficient plant had high root bound membrane reductase capacity while the iron inefficient plants reductase levels remained low, further limiting iron uptake through the root.	Iron	35-39	chalcone reductase CHR1	Glycine max	85-94
17031680-9	2007	Depletion of the body Fe stores dramatically upregulated DMT1 and MTP1 mRNA expression in the duodenum as well as moderately upregulating their expression in several other peripheral tissues.	Iron	22-24	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	57-61
17031680-10	2007	The iron response element positive isoform of DMT1 was the most prominently upregulated isoform in the duodenum.	Iron	4-8	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	46-50
18154662-19	2007	Under iron-limited conditions, the iron efficient plant had high root bound membrane reductase capacity while the iron inefficient plants reductase levels remained low, further limiting iron uptake through the root.	Iron	35-39	chalcone reductase CHR1	Glycine max	85-94
17031680-11	2007	Thus, DMT1 and MTP1 may play an important role in not only maintaining Fe levels but also facilitating the accumulation of Cd in the body of mammals.	Iron	71-73	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	6-10
19513844-4	2010	Serum ferritin correlated with ALT and GGT, whereas serum iron did so with GGT.	Iron	58-62	gamma-glutamyltransferase light chain 5 pseudogene	Homo sapiens	75-78
17401378-3	2007	So far, four highly conserved proteins (Cfd1, Nbp35, Nar1 and Cia1) have been identified as members of the cytosolic [Fe-S] protein assembly machinery, but their molecular function is unresolved.	Iron	118-122	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	53-57
20641669-5	2004	The Tf receptor (TfR) mediates the internalization of iron-loaded Tf into cells (4, 5).	Iron	54-58	transferrin receptor	Homo sapiens	4-15
20641669-5	2004	The Tf receptor (TfR) mediates the internalization of iron-loaded Tf into cells (4, 5).	Iron	54-58	transferrin receptor	Homo sapiens	17-20
20545156-2	2010	The experimental results show that the UV-LIA coefficient change of LiNbO3 : Fe : Mn crystal is not large for congruent sample, increases with increasing Li2 O concentration, reaches the maximum 4.	Iron	77-79	ATP binding cassette subfamily A member 12	Homo sapiens	154-157
17911100-7	2007	In this report we examined for metal-catalyzed oxidation of WRN in the presence of iron or copper.	Iron	83-87	WRN RecQ like helicase	Homo sapiens	60-63
17911100-8	2007	We found that WRN was oxidized in vitro by iron but not by copper.	Iron	43-47	WRN RecQ like helicase	Homo sapiens	14-17
17954932-0	2007	Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.	Iron	14-18	death associated protein	Homo sapiens	68-72
17954932-0	2007	Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.	Iron	14-18	death associated protein	Homo sapiens	74-101
17954932-0	2007	Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.	Iron	14-18	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	111-115
17954932-6	2007	In the present study, we demonstrate that the Dap1 heme-1 domain is required for growth under conditions of low iron availability.	Iron	112-116	death associated protein	Homo sapiens	46-50
17954932-9	2007	The results suggest that Saccharomyces cerevisiae Dap1 stimulates a P450-catalyzed step in sterol synthesis via a distinct localization from its homologues in Schizosaccharomyces pombe and mammals and that this function regulates iron metabolism.	Iron	230-234	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
17401378-3	2007	So far, four highly conserved proteins (Cfd1, Nbp35, Nar1 and Cia1) have been identified as members of the cytosolic [Fe-S] protein assembly machinery, but their molecular function is unresolved.	Iron	118-122	iron-sulfur cluster assembly protein CIA1	Saccharomyces cerevisiae S288C	62-66
17204543-0	2007	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling.	Iron	0-4	hepatocyte growth factor	Homo sapiens	107-110
17280489-2	2007	The present report is focused on involvement of iron-dependent redox signaling in spatial coordination of lung CAM due to either a pulmonary trauma or endotracheal iron administration in rats.	Iron	48-52	calmodulin 1	Rattus norvegicus	111-114
17280489-2	2007	The present report is focused on involvement of iron-dependent redox signaling in spatial coordination of lung CAM due to either a pulmonary trauma or endotracheal iron administration in rats.	Iron	164-168	calmodulin 1	Rattus norvegicus	111-114
17280489-4	2007	We demonstrated for the first time in vivo that the presence of catalytically active iron, deposition of myeloperoxidase, and induction of the oxidative stress in the lung-injury models were accompanied by (a) downregulation of VE-cadherin, (b) upregulation and polarization of ICAM-1 and the PLC integrins, and (c) nuclear translocation and interaction of thioredoxin, Ref-1, and NF-kappaB and complex structural changes in EC and PLC at the sites of their contacts.	Iron	85-89	cadherin 5	Rattus norvegicus	228-239
17280489-4	2007	We demonstrated for the first time in vivo that the presence of catalytically active iron, deposition of myeloperoxidase, and induction of the oxidative stress in the lung-injury models were accompanied by (a) downregulation of VE-cadherin, (b) upregulation and polarization of ICAM-1 and the PLC integrins, and (c) nuclear translocation and interaction of thioredoxin, Ref-1, and NF-kappaB and complex structural changes in EC and PLC at the sites of their contacts.	Iron	85-89	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	370-375
17884229-1	2007	The human transferrin receptor (hTfR1) is a membrane-bound protein involved in transferrin (Tf)-mediated iron uptake and is highly expressed on malignant cells.	Iron	105-109	transferrin receptor	Homo sapiens	32-37
20545156-6	2010	With the increase in Li2 O concentration in the LiNbO3 : Fe : Mn crystal, the amount of the bipolaron increases.	Iron	57-59	ATP binding cassette subfamily A member 12	Homo sapiens	21-24
20545156-11	2010	The amount of bipolaron is the most with 49.57 mol% Li2 O concentration in the LiNbO3 : Fe : Mn crystal.	Iron	88-90	ATP binding cassette subfamily A member 12	Homo sapiens	52-55
17408452-8	2007	HO (inducible HO-1, constitutive HO-2 and HO-3) is the rate-limiting enzyme in haeme catabolism, which leads to the generation of biliverdin, iron, and carbon monoxide.	Iron	142-146	heme oxygenase 2	Homo sapiens	33-37
20053667-2	2010	Frataxin is an iron-binding protein involved in the biogenesis of iron-sulfur clusters (ISC), prosthetic groups allowing essential cellular functions such as oxidative phosphorylation, enzyme catalysis and gene regulation.	Iron	15-19	frataxin	Homo sapiens	0-8
17316903-0	2007	Ceruloplasmin expression and its role in iron transport in C6 cells.	Iron	41-45	ceruloplasmin	Rattus norvegicus	0-13
17316903-1	2007	Ceruloplasmin (CP) is essential for brain iron homeostasis.	Iron	42-46	ceruloplasmin	Rattus norvegicus	0-13
17316903-1	2007	Ceruloplasmin (CP) is essential for brain iron homeostasis.	Iron	42-46	ceruloplasmin	Rattus norvegicus	15-17
17963250-1	2007	Primary iron overload encompasses a variety of genetic iron overload syndromes, dominated in frequency by HFE-related, or Type 1 hemochromatosis, for which French diagnostic and therapeutic guidelines have been recently proposed.	Iron	8-12	homeostatic iron regulator	Homo sapiens	106-109
17887916-3	2007	Physiologic heme degradation is catalyzed by two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding carbon monoxide, iron, and biliverdin, an immediate precursor to bilirubin.	Iron	148-152	heme oxygenase 2	Homo sapiens	116-120
17316903-2	2007	However, little is known about the effect of iron on CP expression in the brain.	Iron	45-49	ceruloplasmin	Rattus norvegicus	53-55
20053667-3	2010	Although several evidence suggest that frataxin acts as an iron-chaperone within the mitochondrial compartment, we have recently demonstrated the existence of a functional extramitochondrial pool of mature frataxin in various human cell types.	Iron	59-63	frataxin	Homo sapiens	39-47
17316903-3	2007	Also, the role of CP in brain iron transport has not been well determined.	Iron	30-34	ceruloplasmin	Rattus norvegicus	18-20
17316903-6	2007	However, western blotting analysis demonstrated that cell iron overload induced a significant decrease in CP protein content in the cells and that treatment with iron chelators led to a significant increase in CP protein level in the cells.	Iron	58-62	ceruloplasmin	Rattus norvegicus	106-108
17727661-3	2007	The prokaryotic frataxin homolog, CyaY, has been shown to bind and donate iron for the assembly of [2Fe-2S] clusters in vitro.	Iron	74-78	frataxin	Homo sapiens	16-24
20053667-6	2010	We demonstrate that the extramitochondrial form of frataxin directly interacts with cytosolic aconitase/iron regulatory protein-1 (IRP1), a bifunctional protein alternating between an enzymatic and a RNA-binding function through the "iron-sulfur switch" mechanism.	Iron	104-108	frataxin	Homo sapiens	51-59
17727661-3	2007	The prokaryotic frataxin homolog, CyaY, has been shown to bind and donate iron for the assembly of [2Fe-2S] clusters in vitro.	Iron	74-78	frataxin	Homo sapiens	34-38
17727661-6	2007	We show that in this strain CyaY complements to a large extent the loss of iron-sulfur cluster enzyme activities and heme synthesis, and thereby maintains a nearly normal respiratory growth.	Iron	75-79	frataxin	Homo sapiens	28-32
17316903-6	2007	However, western blotting analysis demonstrated that cell iron overload induced a significant decrease in CP protein content in the cells and that treatment with iron chelators led to a significant increase in CP protein level in the cells.	Iron	162-166	ceruloplasmin	Rattus norvegicus	210-212
20053667-6	2010	We demonstrate that the extramitochondrial form of frataxin directly interacts with cytosolic aconitase/iron regulatory protein-1 (IRP1), a bifunctional protein alternating between an enzymatic and a RNA-binding function through the "iron-sulfur switch" mechanism.	Iron	104-108	aconitase 1	Homo sapiens	131-135
17324237-2	2007	We showed that high external pH led to increased expression of four iron uptake genes (LeIRT1, LeIRT2, LeFRO1, LeNRAMP1) regardless of the nitrogen sources.	Iron	68-72	ferric-chelate reductase	Solanum lycopersicum	103-109
17727661-7	2007	In addition, CyaY effectively protects yfh1Delta from oxidative damage during treatment with hydrogen peroxide but is less efficient in detoxifying excess labile iron during aerobic growth.	Iron	162-166	frataxin	Homo sapiens	13-17
17324237-7	2007	The enhanced expression of LeFRO1, LeIRT1 and LeNRAMP1 under the culture condition with high pH or on agar media with NO(3) (-) as the sole N source might be a consequence of reduced iron availability in the solution or agar medium at high pH.	Iron	183-187	ferric-chelate reductase	Solanum lycopersicum	27-33
20053667-6	2010	We demonstrate that the extramitochondrial form of frataxin directly interacts with cytosolic aconitase/iron regulatory protein-1 (IRP1), a bifunctional protein alternating between an enzymatic and a RNA-binding function through the "iron-sulfur switch" mechanism.	Iron	234-238	frataxin	Homo sapiens	51-59
17182845-1	2007	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe(2)Tf).	Iron	105-109	transferrin receptor	Homo sapiens	48-70
18079564-1	2007	HFE-related hereditary haemochromatosis (HH) is an iron overload disease attributed to the highly prevalent homozygosity for the C282Y mutation in the HFE gene.	Iron	51-55	homeostatic iron regulator	Homo sapiens	0-3
20053667-6	2010	We demonstrate that the extramitochondrial form of frataxin directly interacts with cytosolic aconitase/iron regulatory protein-1 (IRP1), a bifunctional protein alternating between an enzymatic and a RNA-binding function through the "iron-sulfur switch" mechanism.	Iron	234-238	aconitase 1	Homo sapiens	131-135
17182845-1	2007	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe(2)Tf).	Iron	105-109	transferrin receptor	Homo sapiens	72-76
20338412-9	2010	Interference with the iron-uptake systems of the Pseudomonas spp.	Iron	22-26	histocompatibility minor 13	Homo sapiens	61-64
17266307-0	2007	Modeling the 2-His-1-carboxylate facial triad: iron-catecholato complexes as structural and functional models of the extradiol cleaving dioxygenases.	Iron	47-51	viral integration site 1	Homo sapiens	15-20
17266307-2	2007	These enzymes are part of the superfamily of dioxygen-activating mononuclear non-heme iron enzymes that feature the so-called 2-His-1-carboxylate facial triad.	Iron	86-90	viral integration site 1	Homo sapiens	128-133
17266307-5	2007	For the first time, a mononuclear iron complex has been synthesized, which is facially capped by a ligand offering a tridentate Nim,Nim,Ocarb donor set, identical to the endogenous ligands of the 2-His-1-carboxylate facial triad.	Iron	34-38	viral integration site 1	Homo sapiens	198-203
19942354-6	2010	On the basis of this premise and in the light of the finding in a small observational study that HFE gene mutations are very common in precocious bilateral hip OA (100% amongst 8 sequentially collected patients), it is hypothesised that precocious bilateral hip OA is a "form-fruste" of the arthropathy of HH in which HFE gene mutation mediated articular iron deposition in hip joint tissues may be of pivotal pathogenetic importance.	Iron	355-359	homeostatic iron regulator	Homo sapiens	97-100
20401791-8	2010	HUVEC incubated with glycated protein (GFBS) either alone or combined with iron chelate showed a significant (p &lt; 0.001) elevation of LPO accompanied by depletion of superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased GST activities.	Iron	75-79	glutathione-disulfide reductase	Homo sapiens	234-255
17258206-3	2007	Experimental evidences suggest that frataxin acts as an iron-chaperone protein, donating iron to the proteins involved in [Fe-S] cluster assembly and heme synthesis.	Iron	56-60	frataxin	Homo sapiens	36-44
17258206-3	2007	Experimental evidences suggest that frataxin acts as an iron-chaperone protein, donating iron to the proteins involved in [Fe-S] cluster assembly and heme synthesis.	Iron	89-93	frataxin	Homo sapiens	36-44
17258206-3	2007	Experimental evidences suggest that frataxin acts as an iron-chaperone protein, donating iron to the proteins involved in [Fe-S] cluster assembly and heme synthesis.	Iron	123-127	frataxin	Homo sapiens	36-44
17373738-10	2007	The staining intensity of these proteins varied according to the iron nutrition in humans, with intense staining of transferrin receptor observed in iron deficient subjects.	Iron	65-69	transferrin receptor	Homo sapiens	116-136
17373738-10	2007	The staining intensity of these proteins varied according to the iron nutrition in humans, with intense staining of transferrin receptor observed in iron deficient subjects.	Iron	149-153	transferrin receptor	Homo sapiens	116-136
20401791-8	2010	HUVEC incubated with glycated protein (GFBS) either alone or combined with iron chelate showed a significant (p &lt; 0.001) elevation of LPO accompanied by depletion of superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased GST activities.	Iron	75-79	glutathione-disulfide reductase	Homo sapiens	257-259
19943190-7	2010	Results indicate that TfR, H-ferritin, and IRP2 mRNA expression was differentially affected by aging and by neonatal iron treatment in all three brain regions.	Iron	117-121	transferrin receptor	Rattus norvegicus	22-25
17234227-10	2007	Fe supplement among Pb-exposed rats maintained the normal ultra-structure of the BBB and restored the expression of occludin to normal levels.	Iron	0-2	occludin	Rattus norvegicus	116-124
20113438-7	2010	Mutations in the cognate E3 ligases RGLG2 and RGLG1 caused the constitutive formation of branched root hairs independent of the Fe supply, indicating the involvement of polyubiquitination in the altered differentiation of rhizodermal cells.	Iron	128-130	RING domain ligase2	Arabidopsis thaliana	36-41
17174341-9	2007	It also reduces the activity of both IDO and 3-HAO, which could be attributed to the superoxide anion scavenging and iron binding properties, respectively, of this drug.	Iron	117-121	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	37-40
19874572-4	2010	A second objective was to evaluate the effect of iron supplementation in donors having HFE-variants compared to HFE wild types.	Iron	49-53	homeostatic iron regulator	Homo sapiens	87-90
20231473-5	2010	Here we demonstrate that the sparse oceanic Pseudonitzschia community at the high-nitrate, low-chlorophyll Ocean Station PAPA (50 degrees N, 145 degrees W) produces approximately 200 pg DA L(-1) in response to iron addition, that DA alters phytoplankton community structure to benefit Pseudonitzschia, and that oceanic cell isolates are toxic.	Iron	210-214	pappalysin 1	Homo sapiens	121-125
20042601-0	2010	Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.	Iron	91-103	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	69-73
20042601-4	2010	We find that, with iron, the 50% inhibitory concentrations of nickel (IC(50) [Ni(II)]) are 25 microm for JMJD1A and 7.5 microm for ABH2.	Iron	19-23	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	131-135
20232409-4	2010	Another mechanism for the control of iron absorption by the enterocyte is an active Iron Responsive Element (IRE)/Iron Regulatory Protein (IRP) system.	Iron	37-41	Wnt family member 2	Homo sapiens	139-142
20232409-4	2010	Another mechanism for the control of iron absorption by the enterocyte is an active Iron Responsive Element (IRE)/Iron Regulatory Protein (IRP) system.	Iron	84-88	Wnt family member 2	Homo sapiens	139-142
20232409-5	2010	The IRE/IRP system regulates the expression of iron uptake and storage proteins thus regulating iron absorption.	Iron	47-51	Wnt family member 2	Homo sapiens	8-11
20232409-5	2010	The IRE/IRP system regulates the expression of iron uptake and storage proteins thus regulating iron absorption.	Iron	96-100	Wnt family member 2	Homo sapiens	8-11
20190684-1	2010	The aim of this study was to assess occurrence of iron overload in relation to polymorphism of the HFE and the influence of both these factors on efficacy of antiviral treatment with pegylated interferon and ribavirin in patients with CHC.	Iron	50-54	homeostatic iron regulator	Homo sapiens	99-102
20305775-5	2010	A mechanism involving the initial formation of the 16e(-) intermediate (eta(5)-C(5)H(5))Fe(CO)Me followed by oxidative addition of the Fe-Si bond, accounts for the experimental results obtained.	Iron	88-90	endothelin receptor type A	Homo sapiens	72-75
20084012-10	2010	The frequent occurrence of beta-thalassemia trait and HFE-H63D in non-Ashkenazi Jews raises the possibility of genetic interactions contributing to iron overload when coinherited and requires further evaluation.	Iron	148-152	homeostatic iron regulator	Homo sapiens	54-57
20105537-11	2010	As determined by real-time reverse transcription PCR, relative hepatic expression of the gene that encodes the Fe regulatory hormone hepcidin was 5-fold greater in calves fed high dietary Fe.	Iron	111-113	hepcidin antimicrobial peptide	Bos taurus	133-141
20105537-12	2010	Hepcidin is released in response to increased Fe status and binds to the Fe export protein ferroportin causing ferroportin to be degraded, thereby reducing dietary Fe absorption.	Iron	46-48	hepcidin antimicrobial peptide	Bos taurus	0-8
20105537-12	2010	Hepcidin is released in response to increased Fe status and binds to the Fe export protein ferroportin causing ferroportin to be degraded, thereby reducing dietary Fe absorption.	Iron	73-75	hepcidin antimicrobial peptide	Bos taurus	0-8
20105537-16	2010	In summary, feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents.	Iron	42-44	hepcidin antimicrobial peptide	Bos taurus	71-79
20105537-16	2010	In summary, feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents.	Iron	114-116	hepcidin antimicrobial peptide	Bos taurus	71-79
20018808-6	2010	As determined by quantitative real-time PCR, hepatic expression of hepcidin (HAMP) in pigs given the high-Fe diet was 6.25-fold that of control pigs.	Iron	106-108	HAMP	Sus scrofa	77-81
20018808-7	2010	In the intestine, relative mRNA levels of ferroportin, divalent metal transporter 1, and transferrin receptor were downregulated by high Fe.	Iron	137-139	solute carrier family 11 member 2	Sus scrofa	55-109
17905921-0	2007	Two iron-responsive promoter elements control expression of FOX1 in Chlamydomonas reinhardtii.	Iron	4-8	uncharacterized protein	Chlamydomonas reinhardtii	60-64
19879168-0	2010	A common SNP near BMP2 is associated with severity of the iron burden in HFE p.C282Y homozygous patients: a follow-up study.	Iron	58-62	bone morphogenetic protein 2	Homo sapiens	18-22
17905921-1	2007	FOX1 encodes an iron deficiency-induced ferroxidase involved in a high-affinity iron uptake system.	Iron	16-20	uncharacterized protein	Chlamydomonas reinhardtii	0-4
17905921-2	2007	Mutagenesis analysis of the FOX1 promoter identified two separate iron-responsive elements, FeRE1 (CACACG) and FeRE2 (CACGCG), between positions -87 and -82 and between positions -65 and -60, respectively, and both are needed for induced FOX1 expression under conditions of iron deficiency.	Iron	66-70	uncharacterized protein	Chlamydomonas reinhardtii	28-32
17905921-2	2007	Mutagenesis analysis of the FOX1 promoter identified two separate iron-responsive elements, FeRE1 (CACACG) and FeRE2 (CACGCG), between positions -87 and -82 and between positions -65 and -60, respectively, and both are needed for induced FOX1 expression under conditions of iron deficiency.	Iron	66-70	uncharacterized protein	Chlamydomonas reinhardtii	238-242
20000481-2	2010	In the M = 2S + 1 = 13 (S is the total spin) ground state (GS) of Fe(6)-(C(6)H(6))(3) each benzene is bonded with one Fe atom, forming eta(6) coordinations with C-Fe contacts of 2.12-2.17 A; though the Fe(6) cluster structure is preserved, it presents more distortion than in bare Fe(6).	Iron	66-68	endothelin receptor type A	Homo sapiens	135-138
17927572-2	2007	Therapeutic strategies designed to interfere with tumor iron metabolism have targeted TfR.	Iron	56-60	transferrin receptor	Homo sapiens	86-89
20000481-3	2010	The M = 13 GS of Fe(6)-(C(6)H(6))(4) shows a more distorted geometry with three eta(6) and one eta(2) coordinations, as the bonding with the fourth benzene was reduced to two C-Fe bonds.	Iron	17-19	endothelin receptor type A	Homo sapiens	80-83
20000481-3	2010	The M = 13 GS of Fe(6)-(C(6)H(6))(4) shows a more distorted geometry with three eta(6) and one eta(2) coordinations, as the bonding with the fourth benzene was reduced to two C-Fe bonds.	Iron	17-19	endothelin receptor type A	Homo sapiens	95-98
20862391-5	2010	GLRX5 is involved in the production and ABCB7 in the export of an unknown factor that may function as a gauge of mitochondrial iron status, which may indirectly modulate activity of iron regulatory proteins (IRPs).	Iron	127-131	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Danio rerio	40-45
17631934-3	2007	Our recent studies showed that CDK2 participates in HIV-1 transcription and viral replication suggesting that inhibition of CDK2 by iron chelators might also affect HIV-1 transcription.	Iron	132-136	cyclin dependent kinase 2	Homo sapiens	31-35
17631934-3	2007	Our recent studies showed that CDK2 participates in HIV-1 transcription and viral replication suggesting that inhibition of CDK2 by iron chelators might also affect HIV-1 transcription.	Iron	132-136	cyclin dependent kinase 2	Homo sapiens	124-128
17631934-9	2007	In conclusion, our findings add to the evidence that iron chelators can inhibit HIV-1 transcription by deregulating CDK2 and CDK9.	Iron	53-57	cyclin dependent kinase 2	Homo sapiens	116-120
19783835-0	2010	Dermal and inhalation exposure to methylene bisphenyl isocyanate (MDI) in iron foundry workers.	Iron	74-78	MAFD2	Homo sapiens	66-69
17893816-6	2007	Although no unambiguous proposal for the structure of Int(2) can be made, it is most probably the product of the four-electron oxidation of the original Fe(III)TPPS, contains an iron-oxo center and has a dissociable proton with a pK of around 3.1.	Iron	178-182	fibroblast growth factor 3	Homo sapiens	54-59
17892986-12	2007	CONCLUSIONS: In anemic patients with CHF, correction of anemia with EPO and oral iron over 1 year lead to an improvement in LV systolic function, LV remodeling, BNP levels, and PAP compared with a control group in which only oral iron was used.	Iron	81-85	natriuretic peptide B	Homo sapiens	161-164
19903172-0	2010	Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification.	Iron	36-40	beaded filament structural protein 1	Homo sapiens	58-62
17909017-2	2007	The present study identified a cis-acting element mediating the transactivation of the NDRG1 gene in murine RAW264.7 macrophage cells treated with hypoxia or deferoxamine, an iron chelator mimicking hypoxia.	Iron	175-179	N-myc downstream regulated gene 1	Mus musculus	87-92
18073584-1	2007	PURPOSE: The HEIRS Study screened 101,168 primary care participants for iron overload with serum transferrin saturation (TS), serum ferritin (SF), and C282Y and H63D mutations of the HFE gene.	Iron	72-76	homeostatic iron regulator	Homo sapiens	183-186
17706667-1	2007	The hydrogenase maturation protein HypE serves an essential function in the biosynthesis of the nitrile group, which is subsequently coordinated to Fe as CN(-) ligands in [Ni-Fe] hydrogenase.	Iron	148-150	hypE	Desulfovibrio vulgaris str. Hildenborough	35-39
17284743-8	2007	Absolute heme-iron absorption was higher in the group with higher zinc intakes, but only for those with the lowest heme-iron intake (2 mg; P = 0.0147).	Iron	14-18	HEME	Bos taurus	9-13
17284743-10	2007	CONCLUSIONS: Heme iron intrinsically labeled with (58)Fe can be produced at sufficient enrichments for use in human studies.	Iron	18-22	HEME	Bos taurus	13-17
19238537-1	2010	Transferrin receptor (CD71) is involved in the cellular uptake of iron and is expressed on cells with high proliferation.	Iron	66-70	transferrin receptor	Homo sapiens	0-20
17284743-10	2007	CONCLUSIONS: Heme iron intrinsically labeled with (58)Fe can be produced at sufficient enrichments for use in human studies.	Iron	54-56	HEME	Bos taurus	13-17
17284743-11	2007	In children, heme iron and zinc absorption decrease as the dose of each mineral increases.	Iron	18-22	HEME	Bos taurus	13-17
17284743-13	2007	At lower heme intakes, zinc intakes may increase heme-iron absorption.	Iron	54-58	HEME	Bos taurus	49-53
17284746-7	2007	RESULTS: Significant differences in hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin responses were found between the nonthalassemia group and the 3 groups with the Hb E gene after adjustment for the following baseline values: age, body mass index, duration of iron supplementation, and ferritin concentration.	Iron	281-285	hemoglobin subunit epsilon 1	Homo sapiens	185-189
17603097-0	2007	Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin.	Iron	27-31	Ferritin 1 heavy chain homologue	Drosophila melanogaster	105-113
17603097-1	2007	Ferritin is a symmetric, 24-subunit iron-storage complex assembled of H and L chains.	Iron	36-40	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
17603097-5	2007	Ferritin overexpression impaired the survival of iron-deprived flies.	Iron	49-53	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
17603097-6	2007	In vivo expression of GFP-tagged holoferritin confirmed that iron-loaded ferritin molecules traffic through the Golgi organelle and are secreted into hemolymph.	Iron	61-65	Ferritin 1 heavy chain homologue	Drosophila melanogaster	37-45
17603097-8	2007	Differential cellular expression, conserved post-transcriptional regulation via the iron regulatory element, and distinct subcellular localization of the ferritin subunits prior to the assembly of holoferritin are all important steps mediating iron homeostasis.	Iron	244-248	Ferritin 1 heavy chain homologue	Drosophila melanogaster	154-162
19238537-1	2010	Transferrin receptor (CD71) is involved in the cellular uptake of iron and is expressed on cells with high proliferation.	Iron	66-70	transferrin receptor	Homo sapiens	22-26
20027482-1	2010	Mutations of the HFE and TFR2 genes have been associated with iron overload.	Iron	62-66	homeostatic iron regulator	Homo sapiens	17-20
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	137-141	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	46-53
17244191-8	2007	Despite the iron-binding capacity of IRP1 and the readily synthesis of iron-sulfur clusters in mitochondria, the dense particles were not iron-rich, as indicated by elemental analysis of purified mitochondria.	Iron	12-16	aconitase 1	Homo sapiens	37-41
17460390-7	2007	Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan.	Iron	82-86	transferrin receptor	Rattus norvegicus	77-80
17521857-2	2007	The p.Cys282Tyr mutation of the HFE gene leads to an abnormal reduction in hepatic expression of hepcidin, a protein that appears to control the release of iron from enterocytes and macrophages towards plasma.	Iron	156-160	homeostatic iron regulator	Homo sapiens	32-35
17521857-6	2007	Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP).	Iron	99-103	homeostatic iron regulator	Homo sapiens	178-181
20027482-5	2010	In contrast, men carrying the HFE 282CY genotype had lower total iron-binding capacity (TIBC) than HFE 282CC genotype carriers.	Iron	65-69	homeostatic iron regulator	Homo sapiens	30-33
17540536-0	2007	[Non-HFE-related hereditary iron overload].	Iron	28-32	homeostatic iron regulator	Homo sapiens	5-8
17227093-14	2007	Nevertheless, the FE model was able to successfully simulate both the behavior of the 3GCF, and a wide range of cadaveric bone data scatter by an appropriate adjustment of Young"s modulus or geometric size.	Iron	18-20	GC-rich sequence DNA-binding factor 2	Homo sapiens	87-90
17540536-1	2007	Hereditary iron overload is mainly due to mutations of the HFE gene, implicated in most cases of hereditary hemochromatosis.	Iron	11-15	homeostatic iron regulator	Homo sapiens	59-62
20027482-11	2010	The HFE C282Y and H63D mutations were associated with alterations in iron status in blood donors in a gender-dependent manner.	Iron	69-73	homeostatic iron regulator	Homo sapiens	4-7
17540536-2	2007	Non-HFE-related hereditary iron overload is rare.	Iron	27-31	homeostatic iron regulator	Homo sapiens	4-7
19485930-7	2010	There is evidence that visfatin expression and circulating levels are influenced by fat area and distribution, inflammatory state, renal function, iron metabolism, hormones as well as several other factors.	Iron	147-151	nicotinamide phosphoribosyltransferase	Homo sapiens	23-31
17540536-9	2007	Other causes of non-HFE-related hereditary iron overload are usually associated with recognizable clinical manifestations, such as anemia or neurological disorders.	Iron	43-47	homeostatic iron regulator	Homo sapiens	20-23
17244486-4	2007	The modification of cellular iron metabolism, which involved the increased expression of high-affinity iron transport genes (FET3 and FTR1), was detected via Northern blot analysis.	Iron	29-33	ferroxidase FET3	Saccharomyces cerevisiae S288C	125-129
17244486-4	2007	The modification of cellular iron metabolism, which involved the increased expression of high-affinity iron transport genes (FET3 and FTR1), was detected via Northern blot analysis.	Iron	103-107	ferroxidase FET3	Saccharomyces cerevisiae S288C	125-129
17505690-0	2007	Assessment of HFE mutations in patients with iron overload.	Iron	45-49	homeostatic iron regulator	Homo sapiens	14-17
17661442-1	2007	Expression of the ATP-binding cassette transporter ABCB6 has been associated with multiple cellular functions, including resistance to several cytotoxic agents, iron homeostasis, and porphyrin transport.	Iron	161-165	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	51-56
19947890-5	2010	AREAS COVERED IN THIS REVIEW: In this communication, attempts have been made to bring together past as well as present information indicating that i) the P450 active site has two differently accessible allosterically interacting subsites geared for entirely different types of functionally relevant interactions; and ii) substrate binding to the specific protein residues (Site I) forming the reducible high-spin complex and product binding at L(6) (Site II) of the heme iron forming inhibited low-spin complex can regulate the functional state of the enzyme during catalysis.	Iron	471-475	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	154-158
17567778-9	2007	Since erythroid cells acquire iron via receptor-mediated endocytosis of transferrin, these results suggest a role for Htt in making endocytosed iron accessible for cellular utilization.	Iron	30-34	transferrin-a	Danio rerio	72-83
17567778-9	2007	Since erythroid cells acquire iron via receptor-mediated endocytosis of transferrin, these results suggest a role for Htt in making endocytosed iron accessible for cellular utilization.	Iron	144-148	transferrin-a	Danio rerio	72-83
17098454-0	2007	Hepatic iron metabolism gene expression profiles in HFE associated hereditary hemochromatosis.	Iron	8-12	homeostatic iron regulator	Homo sapiens	52-55
17098454-1	2007	BACKGROUND: Individuals with pathogenic mutations in HFE, hemojuvelin (HJV) and transferrin receptor 2 (TfR2) have low levels of hepcidin, but little is known about the hepatic expression of these molecules in patients with physiological iron overload or HFE associated Hemochromatosis (HH).	Iron	238-242	homeostatic iron regulator	Homo sapiens	53-56
17098454-7	2007	In contrast, HFE associated iron overload failed to induce hepcidin or HJV.	Iron	28-32	homeostatic iron regulator	Homo sapiens	13-16
17630737-5	2007	Iron reduction at the cytosolic membrane receptor may be an essential aspect of the periplasmic iron-transport process, and with an E(1/2) of -158 mV (NHE), FeFbpA-SO4 is the most easily reduced of all FeFbpA-X assemblies yet studied.	Iron	0-4	solute carrier family 9 member C1	Homo sapiens	151-154
23496110-6	2010	In the last 13 years, the discoveries of hepcidin and the HFE gene have propelled our understanding of iron metabolism and iron overload disorders.	Iron	103-107	homeostatic iron regulator	Homo sapiens	58-61
17443334-2	2007	Frataxin is a mitochondrial protein, and adequate amounts are essential for cellular iron homeostasis.	Iron	85-89	frataxin	Homo sapiens	0-8
17579565-7	2007	Apparently, the serum proteins ferritin, transferrin and TfR are more appropriate tools for the diagnosis of iron status in newborns.	Iron	109-113	transferrin receptor	Homo sapiens	57-60
17160644-2	2007	Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake.	Iron	154-158	transferrin receptor	Homo sapiens	0-20
17160644-2	2007	Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake.	Iron	154-158	transferrin receptor	Homo sapiens	22-26
20164577-1	2010	Prevalent gene variants involved in iron metabolism [hemochromatosis (HFE) H63D and transferrin C2 (TfC2)] have been associated with higher risk and earlier age at onset of Alzheimer"s disease (AD), especially in men.	Iron	36-40	homeostatic iron regulator	Homo sapiens	70-73
17227437-2	2007	Iron-deficient rats demonstrate significant elevations in extracellular DA and a reduction in dopamine transporter (DAT) densities in the caudate putamen and nucleus accumbens.	Iron	0-4	solute carrier family 6 member 3	Rattus norvegicus	94-114
17227437-2	2007	Iron-deficient rats demonstrate significant elevations in extracellular DA and a reduction in dopamine transporter (DAT) densities in the caudate putamen and nucleus accumbens.	Iron	0-4	solute carrier family 6 member 3	Rattus norvegicus	116-119
17227437-3	2007	To explore possible mechanisms by which cellular iron concentrations control DAT functioning, endogenous DAT-expressing PC12 cells were used to determine the effect of iron chelation on DAT protein and mRNA expression patterns.	Iron	49-53	solute carrier family 6 member 3	Rattus norvegicus	77-80
20020877-10	2007	Other important molecular pathways include iron binding to transferrin in the bloodstream for cellular delivery through the plasma membrane transferrin receptor (TfR1).	Iron	43-47	transferrin receptor	Homo sapiens	162-166
20020877-11	2007	In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism.	Iron	16-20	aconitase 1	Homo sapiens	50-54
20020877-11	2007	In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism.	Iron	16-20	transferrin receptor	Homo sapiens	180-184
17687449-1	2007	BACKGROUND: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship.	Iron	114-118	homeostatic iron regulator	Homo sapiens	76-79
17602958-0	2007	In vitro preparation of iron-substituted human manganese superoxide dismutase: possible toxic properties for mitochondria.	Iron	24-28	superoxide dismutase 2	Homo sapiens	47-77
17602958-1	2007	We prepared an iron-substituted form of recombinant human manganese superoxide dismutase (MnSOD) by using guanidine hydrochloride for the first time as a model of iron-misincorporated MnSOD, the formation of which has been reported by M. Yang et al.	Iron	15-19	superoxide dismutase 2	Homo sapiens	58-88
17602958-1	2007	We prepared an iron-substituted form of recombinant human manganese superoxide dismutase (MnSOD) by using guanidine hydrochloride for the first time as a model of iron-misincorporated MnSOD, the formation of which has been reported by M. Yang et al.	Iron	15-19	superoxide dismutase 2	Homo sapiens	90-95
17602958-1	2007	We prepared an iron-substituted form of recombinant human manganese superoxide dismutase (MnSOD) by using guanidine hydrochloride for the first time as a model of iron-misincorporated MnSOD, the formation of which has been reported by M. Yang et al.	Iron	15-19	superoxide dismutase 2	Homo sapiens	184-189
17602958-1	2007	We prepared an iron-substituted form of recombinant human manganese superoxide dismutase (MnSOD) by using guanidine hydrochloride for the first time as a model of iron-misincorporated MnSOD, the formation of which has been reported by M. Yang et al.	Iron	163-167	superoxide dismutase 2	Homo sapiens	58-88
20020877-11	2007	In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism.	Iron	114-118	aconitase 1	Homo sapiens	16-48
20020877-11	2007	In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism.	Iron	114-118	aconitase 1	Homo sapiens	50-54
20020877-11	2007	In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism.	Iron	114-118	transferrin receptor	Homo sapiens	180-184
17602958-1	2007	We prepared an iron-substituted form of recombinant human manganese superoxide dismutase (MnSOD) by using guanidine hydrochloride for the first time as a model of iron-misincorporated MnSOD, the formation of which has been reported by M. Yang et al.	Iron	163-167	superoxide dismutase 2	Homo sapiens	90-95
17602958-1	2007	We prepared an iron-substituted form of recombinant human manganese superoxide dismutase (MnSOD) by using guanidine hydrochloride for the first time as a model of iron-misincorporated MnSOD, the formation of which has been reported by M. Yang et al.	Iron	163-167	superoxide dismutase 2	Homo sapiens	184-189
17602958-5	2007	The iron-substituted enzyme contained 0.79 g atoms of Fe/mol of subunits and had a specific activity of 80 units/mg protein/g atom of Fe/mol of subunit, which was less than 3% of the activity of the purified MnSOD.	Iron	4-8	superoxide dismutase 2	Homo sapiens	208-213
17602958-8	2007	The Fe-substituted enzyme showed a hydrogen-peroxide-mediated radical-generating activity, which was monitored by a cation radical of 2,2"-azinobis-(3-ethylbenzthiazoline-6-sulfonate) formation similar to that of Cu,ZnSOD, but native human MnSOD and FeSOD showed no radical-generation ability.	Iron	4-6	superoxide dismutase 2	Homo sapiens	240-245
17602958-9	2007	This evidence suggests that a substitution of Mn to Fe in human MnSOD in mitochondria may produce a disadvantage for oxidative stress in three ways: loss of the enzymatic activity, increase of stability, and gain of radical-generating ability.	Iron	52-54	superoxide dismutase 2	Homo sapiens	64-69
17185597-1	2006	Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme.	Iron	39-43	aconitase 1	Homo sapiens	0-25
17185597-1	2006	Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme.	Iron	39-43	aconitase 1	Homo sapiens	27-31
17185597-1	2006	Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme.	Iron	149-153	aconitase 1	Homo sapiens	0-25
20164577-3	2010	The effects of the common genetic variants (HFE H63D and/or TfC2) on brain iron were studied across eight brain regions (caudate, putamen, globus pallidus, thalamus, hippocampus, white matter of frontal lobe, genu, and splenium of corpus callosum) in 66 healthy adults (35 men, 31 women) aged 55 to 76.	Iron	75-79	homeostatic iron regulator	Homo sapiens	44-47
17185597-1	2006	Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme.	Iron	149-153	aconitase 1	Homo sapiens	27-31
17185597-4	2006	Extensive conformational changes related to binding the IRE or an iron-sulfur cluster explain the alternate functions of IRP1 as an mRNA regulator or enzyme.	Iron	66-70	aconitase 1	Homo sapiens	121-125
17640859-11	2007	The C282Y HFE mutation, hepcidin and beta-globin mutations influenced iron stores.	Iron	70-74	homeostatic iron regulator	Homo sapiens	10-13
19939449-0	2010	Macrophage-inflammatory protein-3alpha/CCL-20 is transcriptionally induced by the iron chelator desferrioxamine in human mononuclear phagocytes through nuclear factor (NF)-kappaB.	Iron	82-86	C-C motif chemokine ligand 20	Homo sapiens	0-38
19939449-0	2010	Macrophage-inflammatory protein-3alpha/CCL-20 is transcriptionally induced by the iron chelator desferrioxamine in human mononuclear phagocytes through nuclear factor (NF)-kappaB.	Iron	82-86	C-C motif chemokine ligand 20	Homo sapiens	39-45
17553781-8	2007	Furthermore, both CTR2 and FRE6 mRNA levels are regulated by iron availability.	Iron	61-65	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	27-31
20802456-0	2010	Effects of growth hormone and insulin-like growth factor-I on the iron-induced lipid peroxidation in the rat liver and porcine thyroid homogenates.	Iron	66-70	gonadotropin releasing hormone receptor	Rattus norvegicus	11-25
17517884-8	2007	Our results suggest a novel mechanism of iron accumulation by sustained H(2)O(2), based on the translational activation of TfR1, which could provide an important (patho) physiological link between iron metabolism and inflammation.	Iron	197-201	transferrin receptor	Homo sapiens	123-127
17564444-3	2007	We have demonstrated that the first high-spin iron hydride complex, LtBuFeH (LtBu = bulky beta-diketiminate), reacts with PhN=NPh to completely cleave the N-N double bond, giving LtBuFeNHPh.	Iron	46-58	carbamoyl-phosphate synthase 1	Homo sapiens	122-125
17073778-3	2006	The crystallographic analysis of the deformability of two bacterial P450 active sites associated with the binding of azole (a class of inhibitors with an imidazole or triazole ring that co-ordinates to the haem iron) inhibitors described in the present study illustrates the importance of protein conformational malleability in the binding of imidazole derivatives.	Iron	211-215	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Iron	264-268	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	64-68
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Iron	264-268	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	172-176
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Iron	264-268	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	172-176
17073780-8	2006	The accessory flavoprotein and iron-sulfur proteins required to drive P450 catalysis are also discussed, providing an overview of the current state of knowledge of Mtb P450 redox systems.	Iron	31-35	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	70-74
20802456-3	2010	The aim of the study was to evaluate the effect of GH and/or IGF-I on the iron-induced LPO in the rat liver and porcine thyroid homogenates.	Iron	74-78	gonadotropin releasing hormone receptor	Rattus norvegicus	51-53
20802456-8	2010	In porcine thyroid homogenates, GH--in its two lowest concentrations--prevented, whereas in other concentrations, it enhanced the iron-induced LPO.	Iron	130-134	gonadotropin releasing hormone receptor	Rattus norvegicus	32-34
17105489-0	2006	Improved preoperative iron status assessment by soluble transferrin receptor in elderly patients undergoing knee and hip replacement.	Iron	22-26	transferrin receptor	Homo sapiens	56-76
17666895-1	2007	PURPOSE: The homozygous p.C282Y variant of the HFE gene is a major risk factor for hereditary hemochromatosis, a disorder of iron metabolism resulting in progressive iron accumulation in a variety of organs including the pancreas.	Iron	125-129	homeostatic iron regulator	Homo sapiens	47-50
17666895-1	2007	PURPOSE: The homozygous p.C282Y variant of the HFE gene is a major risk factor for hereditary hemochromatosis, a disorder of iron metabolism resulting in progressive iron accumulation in a variety of organs including the pancreas.	Iron	166-170	homeostatic iron regulator	Homo sapiens	47-50
17105489-2	2006	The soluble transferrin receptor (sTfR) has become a highly specific parameter for the detection of iron deficits as it can differentiate between iron deficiency anaemia and anaemia of chronic disease, because of the lack of effect by associated inflammation, unlike ferritin.	Iron	100-104	transferrin receptor	Homo sapiens	12-32
20055961-5	2010	Expression of AtIRT1, AtFRO2, AtFIT1 and AtFER1 was up-regulated by CO exposure in iron-deficient seedlings.	Iron	83-87	ferric reduction oxidase 2	Arabidopsis thaliana	22-28
17028341-6	2006	Microarray and quantitative real-time PCR analyses revealed five downregulated genes in ilr3-1, including three encoding putative membrane proteins similar to the yeast iron and manganese transporter Ccc1p.	Iron	169-173	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	88-92
17607365-5	2007	Here we show that BMP-2 administration increases hepcidin expression and decreases serum iron levels in vivo.	Iron	89-93	bone morphogenetic protein 2	Homo sapiens	18-23
17399844-6	2007	In addition, transferrin receptor 1 (TfR1) was also downregulated, while ferroportin levels were elevated, resulting in reduced iron uptake and increased iron release capacity of replicon cells.	Iron	154-158	transferrin receptor	Homo sapiens	37-41
20369475-11	2010	The coordinated expression regulation of these key iron metabolism-related molecules during cell differentiation may in turn inhibit TfR1-mediated iron uptake via endocytosis and thus adversely affect cell proliferation potential.	Iron	51-55	transferrin receptor	Homo sapiens	133-137
17200797-3	2007	Total IRP binding to an iron responsive element (IRE) mRNA probe was increased several fold by hypoxia in HEK 293 cells, maximally at 4-8 h. An earlier and more modest increase (1.5- to 2-fold, peaking at 2 h and then declining) was seen in HepG2 cells.	Iron	24-28	Wnt family member 2	Homo sapiens	6-9
17200797-8	2007	Translocation of IRP to the ER has previously been shown to stabilize transferrin receptor mRNA, thus increasing iron availability to the cell.	Iron	113-117	Wnt family member 2	Homo sapiens	17-20
17200797-9	2007	Iron depletion with deferoxamine also caused an increase in ER-associated IRP1.	Iron	0-4	aconitase 1	Homo sapiens	74-78
17084901-4	2006	Iron responsive elements are very similar (65-80% sequence identity), but each mRNA has sufficient IRE specificity (&gt;90% phylogenetic sequence conservation), that IRP binding and signal responses vary quantitatively.	Iron	0-4	Wnt family member 2	Homo sapiens	166-169
17090148-2	2006	Although the current model with the 15 kDa membrane correlates well with human studies, use of mucin may improve the system as the mucus layer is suspected to play a physiological role in Fe absorption.	Iron	188-190	LOC100508689	Homo sapiens	95-100
20369475-11	2010	The coordinated expression regulation of these key iron metabolism-related molecules during cell differentiation may in turn inhibit TfR1-mediated iron uptake via endocytosis and thus adversely affect cell proliferation potential.	Iron	147-151	transferrin receptor	Homo sapiens	133-137
17470555-6	2007	Similar to its mammalian homolog, Jhd1-catalyzed histone demethylation requires iron and alpha-ketoglutarate as cofactors.	Iron	80-84	[Histone H3]-lysine-36 demethylase	Saccharomyces cerevisiae S288C	34-38
20024105-6	2009	In contrast, the efficacy of ApAP as an inhibitor of lipid hydroperoxide biosynthesis by soybean LOX-1 (sLOX-1) increased upon incorporation of nitrogen into the ring, suggesting a different mechanism of inhibition dependent on the acidity of the phenolic O-H which may involve chelation of the catalytic non-heme iron atom.	Iron	314-318	oxidized low density lipoprotein receptor 1	Homo sapiens	104-110
17973580-1	2007	AIM: To disclose whether mutations in the HFE gene inducing liver iron overload are related to the risk of hepatocellular carcinoma (HCC) in otherwise predisposed patients.	Iron	66-70	homeostatic iron regulator	Homo sapiens	42-45
17090148-5	2006	In the presence of mucin, significantly more Fe was taken up from the heme Fe (86%) and ferritin (91%) samples and significantly less Fe was taken up from the white bean samples ( approximately 70%) relative to the 15 kDa membrane.	Iron	45-47	LOC100508689	Homo sapiens	19-24
17090148-5	2006	In the presence of mucin, significantly more Fe was taken up from the heme Fe (86%) and ferritin (91%) samples and significantly less Fe was taken up from the white bean samples ( approximately 70%) relative to the 15 kDa membrane.	Iron	75-77	LOC100508689	Homo sapiens	19-24
17090148-5	2006	In the presence of mucin, significantly more Fe was taken up from the heme Fe (86%) and ferritin (91%) samples and significantly less Fe was taken up from the white bean samples ( approximately 70%) relative to the 15 kDa membrane.	Iron	75-77	LOC100508689	Homo sapiens	19-24
17090148-6	2006	The results indicated that the forms of iron interact with mucin.	Iron	40-44	LOC100508689	Homo sapiens	59-64
16904380-1	2006	The transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and in the regulation of cell growth.	Iron	109-113	transferrin receptor	Homo sapiens	4-24
19853582-1	2009	Frataxin is a mitochondrial protein that is defective in Friedreich"s ataxia resulting in iron accumulation and an environment prone to Fenton reactions.	Iron	90-94	frataxin	Homo sapiens	0-8
16904380-1	2006	The transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and in the regulation of cell growth.	Iron	109-113	transferrin receptor	Homo sapiens	26-29
17101320-0	2006	Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C. BACKGROUND &amp; AIMS: Iron overload may cause or contribute to hepatic injury and fibrosis.	Iron	143-147	homeostatic iron regulator	Homo sapiens	18-21
17101320-1	2006	Mutations in the HFE gene may influence development or progression of chronic liver disease by increasing iron stores or modulating immune responses.	Iron	106-110	homeostatic iron regulator	Homo sapiens	17-20
18293685-3	2007	The discovery of HFE gene has established the foundation for a better understanding of iron homeostasis and has changed hemochromatosis management: liver biopsy, gold standard diagnostic, was replaced by genetic test and it was suggested that population screening using genetic testing might be ideal for HFE related hemochromatosis.	Iron	87-91	homeostatic iron regulator	Homo sapiens	17-20
18293685-6	2007	The basic features shared by iron overload disorders associated with mutation in HFE, hepcidine, hemojuvelin, transferring receptor 2, ferroportin gene indicate that they are genetic variation of the same syndrome.	Iron	29-33	homeostatic iron regulator	Homo sapiens	81-84
19864422-9	2009	We therefore propose that human IscA1 plays an important role in both mitochondrial and cytosolic iron-sulfur cluster biogenesis, and a notable component of the latter is the interaction between IscA1 and IOP1.	Iron	98-102	cytosolic iron-sulfur assembly component 3	Homo sapiens	205-209
17589946-12	2007	CONCLUSION: Primary iron overload in Indians is non-HFE type, which is different from that in Europeans and further molecular studies are required to determine the defect in various iron regulatory genes.	Iron	20-24	homeostatic iron regulator	Homo sapiens	52-55
17311997-6	2007	This parallel decrease in L-ferritin and TfR in HA occurs independently of increased hypoxia-inducible factor 1 (HIF-1) mRNA levels and unchanged binding activity of iron regulatory proteins, but concurrently with increased ferroportin mRNA levels, suggesting enhanced iron export.	Iron	269-273	transferrin receptor	Homo sapiens	41-44
17320946-3	2007	More specifically, we show that exposure to increasing concentrations of anionic MNPs, from 0.15 to 15 mm of iron, results in a dose-dependent diminishing viability and capacity of PC12 cells to extend neurites in response to their putative biological cue, i.e. nerve growth factor.	Iron	109-113	nerve growth factor	Rattus norvegicus	262-281
17521334-12	2007	Although the iron-responsive element does not itself hydrolyze ATP, its presence enhances iron regulatory protein-1"s ATPase activity, and ATP hydrolysis results in loss of the complex in gel shift assays.	Iron	13-17	aconitase 1	Homo sapiens	90-115
17101320-11	2006	CONCLUSIONS: Although HFE mutations (especially the most frequent H63D mutation) are associated with increased iron loading, they are also associated with increased sustained virologic responses in US patients with advanced chronic hepatitis C.	Iron	111-115	homeostatic iron regulator	Homo sapiens	22-25
16823846-2	2006	Prior studies have shown that the wild-type hemochromatosis gene (wt HFE) may downregulate iron uptake and alter iron homeostasis in cells.	Iron	91-95	homeostatic iron regulator	Homo sapiens	69-72
16823846-2	2006	Prior studies have shown that the wild-type hemochromatosis gene (wt HFE) may downregulate iron uptake and alter iron homeostasis in cells.	Iron	113-117	homeostatic iron regulator	Homo sapiens	69-72
16823846-10	2006	Our studies suggest that HFE expression and its consequent effect on cellular iron homeostasis may modulate doxorubicin-induced oxidative stress and apoptosis in breast cancer cells.	Iron	78-82	homeostatic iron regulator	Homo sapiens	25-28
19475341-0	2009	Total iron and heme iron content and their distribution in beef meat and viscera.	Iron	20-24	HEME	Bos taurus	15-19
17065470-7	2006	For example, herein it is shown that one regulator of systemic iron homeostasis, HFE, is expressed in the RPE.	Iron	63-67	homeostatic iron regulator	Homo sapiens	81-84
17065470-8	2006	Thus, patients with the common disease hereditary hemochromatosis, which is often caused by an HFE mutation, may have retinal iron overload predisposing to AMD.	Iron	126-130	homeostatic iron regulator	Homo sapiens	95-98
17485244-4	2007	There remains considerable debate as to the normal function of frataxin, but it is likely to be involved in mitochondrial iron handling, antioxidant regulation, and/or iron sulphur centre regulation.	Iron	122-126	frataxin	Homo sapiens	63-71
17485244-4	2007	There remains considerable debate as to the normal function of frataxin, but it is likely to be involved in mitochondrial iron handling, antioxidant regulation, and/or iron sulphur centre regulation.	Iron	168-172	frataxin	Homo sapiens	63-71
20011735-1	2009	The presence of hemochromatosis gene mutations is associated with increased hepatic iron accumulation and may lead to accelerated disease progression.	Iron	84-88	homeostatic iron regulator	Homo sapiens	16-31
17613866-1	2007	Hypertransfusional (&gt;8 transfusions/year) iron in liver biopsies collected immediately after transfusions in beta-thalassemia and sickle cell disease correlated with increased expression (RNA) for iron regulatory proteins 1 and 2 (3-, 9- to 11-fold) and hepcidin RNA: (5- to 8-fold) (each p &lt;.01), while ferritin H and L RNA remained constant.	Iron	45-49	aconitase 1	Homo sapiens	200-232
17042492-0	2006	Structural basis of the ferrous iron specificity of the yeast ferroxidase, Fet3p.	Iron	32-36	ferroxidase FET3	Saccharomyces cerevisiae S288C	75-80
17042492-5	2006	In terms of the Marcus theory of outer-sphere electron transfer, we show here that D283, E185, and D409 in Fet3p provide a Fe(II) binding site that actually favors ferric iron; this site thus reduces the reduction potential of the bound Fe(II) in comparison to that of aqueous ferrous iron, providing a thermodynamically more robust driving force for electron transfer.	Iron	171-175	ferroxidase FET3	Saccharomyces cerevisiae S288C	107-112
19946096-7	2009	CONCLUSION: TfR-F index incorporated the high sensitivity of sTfR, a proxy for cellular iron need, and the high specificity of ferritin, a proxy for iron stores.	Iron	88-92	transferrin receptor	Homo sapiens	12-15
16999395-0	2006	Self-assembly of the 2-His-1-carboxylate facial triad in mononuclear iron(II) and zinc(II) models of metalloenzyme active sites.	Iron	69-73	viral integration site 1	Homo sapiens	23-28
17476391-0	2007	Human frataxin: iron and ferrochelatase binding surface.	Iron	16-20	frataxin	Homo sapiens	6-14
17476391-1	2007	The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein"s ability to serve as the iron chaperone during heme biosynthesis.	Iron	16-20	frataxin	Homo sapiens	75-83
17476391-1	2007	The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein"s ability to serve as the iron chaperone during heme biosynthesis.	Iron	170-174	frataxin	Homo sapiens	75-83
26190951-1	2009	Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization.	Iron	4-8	aconitase 1	Homo sapiens	30-34
16555089-3	2006	Previous in vitro studies have shown that disorders of iron metabolism, including altered IRP1-IRE binding, may be an important mechanism of anthracycline cardiotoxicity.	Iron	55-59	aconitase 1	Rattus norvegicus	90-94
26190951-1	2009	Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization.	Iron	123-127	aconitase 1	Homo sapiens	30-34
17197429-0	2007	Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression.	Iron	0-4	cyclin D1	Homo sapiens	25-34
17197429-0	2007	Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression.	Iron	76-80	cyclin D1	Homo sapiens	25-34
26190951-2	2009	Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.	Iron	55-59	cullin 1	Homo sapiens	109-113
17197429-4	2007	Previously, we examined the effect of Fe depletion on the expression of cell-cycle control molecules and identified a marked decrease in cyclin D1 protein, although the mechanism involved was unknown.	Iron	38-40	cyclin D1	Homo sapiens	137-146
17197429-5	2007	In this study, we showed that cyclin D1 was regulated posttranscriptionally by Fe depletion.	Iron	79-81	cyclin D1	Homo sapiens	30-39
17003411-3	2006	HFE is the principal regulator of iron homeostasis, and the process involves interaction with transferrin receptor (TfR)-1, transferrin receptor (TfR)-2, and beta2-microglobulin (beta2M).	Iron	34-38	homeostatic iron regulator	Homo sapiens	0-3
17003411-13	2006	The specific localization of HFE and its interacting proteins, TfR1 and TfR2, at the basolateral membrane of RPE is relevant to the regulation of iron homeostasis in this cell.	Iron	146-150	homeostatic iron regulator	Homo sapiens	29-32
17003411-13	2006	The specific localization of HFE and its interacting proteins, TfR1 and TfR2, at the basolateral membrane of RPE is relevant to the regulation of iron homeostasis in this cell.	Iron	146-150	transferrin receptor	Homo sapiens	63-67
17197429-6	2007	Iron chelation of cells in culture using desferrioxamine (DFO) or 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) decreased cyclin D1 protein levels after 14 hours and was rescued by the addition of Fe.	Iron	0-4	cyclin D1	Homo sapiens	135-144
17197429-6	2007	Iron chelation of cells in culture using desferrioxamine (DFO) or 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) decreased cyclin D1 protein levels after 14 hours and was rescued by the addition of Fe.	Iron	210-212	cyclin D1	Homo sapiens	135-144
17197429-9	2007	In Fe-replete cells, cyclin D1 was degraded in an ubiquitin-dependent manner, while Fe depletion induced a ubiquitin-independent pathway.	Iron	3-5	cyclin D1	Homo sapiens	21-30
17197429-10	2007	This is the first report linking Fe depletion-mediated growth suppression at G(1)/S to a mechanism inducing cyclin D1 proteolysis.	Iron	33-35	cyclin D1	Homo sapiens	108-117
19838776-1	2009	Complexation of transferrin (Tf) and its receptor (TfR) is an essential event for iron uptake by the cell.	Iron	82-86	transferrin receptor	Homo sapiens	51-54
17020684-0	2006	[Comparison between phlebotomy and erythrocytapheresis of iron overload in patients with HFE gene mutations].	Iron	58-62	homeostatic iron regulator	Homo sapiens	89-92
19290800-4	2009	FTH generated MRI contrast through compensatory upregulation of transferrin receptor (Tfrc) that led to increased cellular iron stored in ferritin-bound form.	Iron	123-127	transferrin receptor	Homo sapiens	64-84
16961363-3	2006	The extent of a structural change of the iron center from a preferred square-pyramidal to a distorted trigonal-bipyramidal geometry varies with the external ligand that is bound in the order Cl &lt;&lt; EtO &lt; H2O, which is consistent with the spectrochemical series.	Iron	41-45	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	203-206
17497533-3	2007	To test this, iron-response protein (IRP) binding activity in a rat AM cell line was assessed after exposure to Fe alone and in conjunction with V, Mn, and/or Al at ratios of V:Fe, Al:Fe, or Mn:Fe encountered in PM2.5 samples from New York City, Los Angeles, and Seattle.	Iron	14-18	caspase 3	Rattus norvegicus	37-40
17497533-3	2007	To test this, iron-response protein (IRP) binding activity in a rat AM cell line was assessed after exposure to Fe alone and in conjunction with V, Mn, and/or Al at ratios of V:Fe, Al:Fe, or Mn:Fe encountered in PM2.5 samples from New York City, Los Angeles, and Seattle.	Iron	112-114	caspase 3	Rattus norvegicus	37-40
17497533-5	2007	We conclude that the reductions in Fe status detected here via the IRP assay arose, in part, from effects on transferrin-mediated Fe3+ delivery to the AM.	Iron	35-37	caspase 3	Rattus norvegicus	67-70
19290800-4	2009	FTH generated MRI contrast through compensatory upregulation of transferrin receptor (Tfrc) that led to increased cellular iron stored in ferritin-bound form.	Iron	123-127	transferrin receptor	Homo sapiens	86-90
19821612-0	2009	A complex between biotin synthase and the iron-sulfur cluster assembly chaperone HscA that enhances in vivo cluster assembly.	Iron	42-46	biotin synthase	Saccharomyces cerevisiae S288C	18-33
17351036-0	2007	A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis.	Iron	17-21	ferric iron uptake transcriptional regulator	Neisseria meningitidis MC58	74-77
17351036-2	2007	In Neisseria meningitidis the majority of iron-responsive gene regulation is mediated by the ferric uptake regulator protein (Fur), a protein classically defined as a transcriptional repressor.	Iron	42-46	ferric iron uptake transcriptional regulator	Neisseria meningitidis MC58	126-129
17351036-3	2007	Recently, however, microarray studies have identified a number of genes in N. meningitidis that are iron and Fur activated, demonstrating a new role for Fur as a transcriptional activator.	Iron	100-104	ferric iron uptake transcriptional regulator	Neisseria meningitidis MC58	153-156
17351036-4	2007	Since Fur has been shown to indirectly activate gene transcription through the repression of small regulatory RNA molecules in other organisms, we hypothesized that a similar mechanism could account for Fur-dependent, iron-activated gene transcription in N. meningitidis.	Iron	218-222	ferric iron uptake transcriptional regulator	Neisseria meningitidis MC58	6-9
17351036-4	2007	Since Fur has been shown to indirectly activate gene transcription through the repression of small regulatory RNA molecules in other organisms, we hypothesized that a similar mechanism could account for Fur-dependent, iron-activated gene transcription in N. meningitidis.	Iron	218-222	ferric iron uptake transcriptional regulator	Neisseria meningitidis MC58	203-206
16973432-4	2006	Three absolutely conserved cysteine residues provide ligands for the Fe-S cluster, which is essential for the helicase activity of XPD.	Iron	69-73	helicase for meiosis 1	Homo sapiens	110-118
16973432-6	2006	Clinically relevant mutations in patients with trichothiodystrophy (TTD) and Fanconi anemia disrupt the Fe-S clusters of XPD and FancJ and thereby abolish helicase activity.	Iron	104-108	helicase for meiosis 1	Homo sapiens	155-163
17351036-6	2007	This screen identified one small RNA, herein named NrrF (for neisserial regulatory RNA responsive to iron [Fe]), which was demonstrated to be both iron responsive and Fur regulated and which has a well-conserved orthologue in N. gonorrhoeae.	Iron	101-105	ferric iron uptake transcriptional regulator	Neisseria meningitidis MC58	167-170
16950869-0	2006	Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.	Iron	48-52	solute carrier family 39 member 14	Homo sapiens	0-5
17351036-6	2007	This screen identified one small RNA, herein named NrrF (for neisserial regulatory RNA responsive to iron [Fe]), which was demonstrated to be both iron responsive and Fur regulated and which has a well-conserved orthologue in N. gonorrhoeae.	Iron	107-109	ferric iron uptake transcriptional regulator	Neisseria meningitidis MC58	167-170
19821612-1	2009	Biotin synthase (BioB) is an iron-sulfur enzyme that catalyzes the last step in biotin biosynthesis, the insertion of sulfur between the C6 and C9 atoms of dethiobiotin to complete the thiophane ring of biotin.	Iron	29-33	biotin synthase	Saccharomyces cerevisiae S288C	0-15
17401378-5	2007	These labile [Fe-S] clusters can be rapidly transferred and incorporated into target [Fe-S] apoproteins in a Nar1- and Cia1-dependent fashion.	Iron	14-18	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	109-113
16950869-0	2006	Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.	Iron	48-52	solute carrier family 39 member 14	Homo sapiens	7-15
16950869-4	2006	We analyzed the capability of Zip14 to mediate non-transferrin-bound iron (NTBI) uptake by overexpressing mouse Zip14 in HEK 293H cells and Sf9 insect cells.	Iron	69-73	solute carrier family 39 (zinc transporter), member 14	Mus musculus	30-35
17401378-5	2007	These labile [Fe-S] clusters can be rapidly transferred and incorporated into target [Fe-S] apoproteins in a Nar1- and Cia1-dependent fashion.	Iron	14-18	iron-sulfur cluster assembly protein CIA1	Saccharomyces cerevisiae S288C	119-123
16950869-5	2006	Zip14 was found to localize to the plasma membrane, and its overexpression increased the uptake of both (65)Zn and (59)Fe.	Iron	119-121	solute carrier family 39 member 14	Homo sapiens	0-5
19715555-14	2009	Wild-type mouse RPE cells and human RPE cell lines, when loaded with iron by exposure to ferric ammonium citrate, showed increased expression and activity of xCT, reproducing the biochemical phenotype observed with Hfe-/- RPE cells.	Iron	69-73	homeostatic iron regulator	Homo sapiens	215-218
16950869-6	2006	Addition of bathophenanthroline sulfonate, a cell-impermeant ferrous iron chelator, inhibited Zip14-mediated iron uptake from ferric citrate, suggesting that iron is taken up by HEK cells as Fe(2+).	Iron	61-73	solute carrier family 39 member 14	Homo sapiens	94-99
16950869-6	2006	Addition of bathophenanthroline sulfonate, a cell-impermeant ferrous iron chelator, inhibited Zip14-mediated iron uptake from ferric citrate, suggesting that iron is taken up by HEK cells as Fe(2+).	Iron	69-73	solute carrier family 39 member 14	Homo sapiens	94-99
16950869-6	2006	Addition of bathophenanthroline sulfonate, a cell-impermeant ferrous iron chelator, inhibited Zip14-mediated iron uptake from ferric citrate, suggesting that iron is taken up by HEK cells as Fe(2+).	Iron	109-113	solute carrier family 39 member 14	Homo sapiens	94-99
16950869-7	2006	Iron uptake by HEK and Sf9 cells expressing Zip14 was inhibited by zinc.	Iron	0-4	solute carrier family 39 member 14	Homo sapiens	44-49
16950869-8	2006	Suppression of endogenous Zip14 expression by using Zip14 siRNA reduced the uptake of both iron and zinc by AML12 mouse hepatocytes.	Iron	91-95	solute carrier family 39 (zinc transporter), member 14	Mus musculus	26-31
16950869-8	2006	Suppression of endogenous Zip14 expression by using Zip14 siRNA reduced the uptake of both iron and zinc by AML12 mouse hepatocytes.	Iron	91-95	solute carrier family 39 (zinc transporter), member 14	Mus musculus	52-57
16950869-10	2006	Collectively, these results indicate that Zip14 can mediate the uptake of zinc and NTBI into cells and that it may play a role in zinc and iron metabolism in hepatocytes, where this transporter is abundantly expressed.	Iron	139-143	solute carrier family 39 member 14	Homo sapiens	42-47
17576385-4	2007	This study compares directly for the first time the effects of the novel hydroxypyridinone iron chelating agent CP94 and the more clinically established iron chelator desferrioxamine (DFO) on the enhancement of ALA and methyl-aminolevulinate (MAL)-induced PpIX accumulations in cultured human cells.	Iron	91-95	beaded filament structural protein 1	Homo sapiens	112-116
17376497-7	2007	These results suggest that aluminum disrupts iron homeostasis in the brain by several mechanisms including the transferrin receptor, a nontransferrin iron transporter, and ferritin.	Iron	45-49	transferrin receptor	Homo sapiens	111-131
16950869-11	2006	Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases.	Iron	92-96	solute carrier family 39 member 14	Homo sapiens	107-112
19787796-1	2009	We sought to identify mutations that could explain iron phenotype heterogeneity in adults with previous HFE genotyping to detect C282Y and H63D.	Iron	51-55	homeostatic iron regulator	Homo sapiens	104-107
16950869-11	2006	Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases.	Iron	164-168	solute carrier family 39 member 14	Homo sapiens	107-112
16879716-5	2006	(59)Fe occurred in significantly lower amounts in the postvascular compartment in Belgrade b/b rats, indicating impaired iron uptake by transferrin receptor and DMT1-expressing neurons.	Iron	121-125	transferrin receptor	Rattus norvegicus	136-156
16937477-8	2006	The positive hepatic iron stain was significantly associated with the values of alanine aminotransferase (ALT) (P = 0.017), ferritin (P = 0.008), serum iron (P = 0.019) and transferrin saturation (P = 0.003).	Iron	21-25	glutamic--pyruvic transaminase	Homo sapiens	80-104
17519113-6	2007	It was found that pretreatment with rutin- iron complex protected against thioacetamide induced hepatotoxicity as observed by a significant reduction in the elevated levels of serum enzymes and partial normalization of GSH/GSSG ratio, glutathione peroxidase II and glutathione reductase activity in mice liver.	Iron	43-47	glutathione reductase	Mus musculus	265-286
17331979-4	2007	Another interactor was ISD11, recently identified as a component of the eukaryotic complex Nfs1/ISCU, an essential component of iron-sulfur cluster biogenesis.	Iron	128-132	Isd11p	Saccharomyces cerevisiae S288C	23-28
17331979-10	2007	Upon ISD11 depletion by siRNA in HEK293T cells, the amount of the Nfs1/ISCU protein complex declined, as did the activity of the iron-sulfur cluster enzyme aconitase, while the cellular iron content was increased, as seen in tissues from FRDA patients.	Iron	129-133	NFS1 cysteine desulfurase	Homo sapiens	66-70
17331979-12	2007	These data suggest that frataxin binds the iron-sulfur biogenesis Nfs1/ISCU complex through ISD11, that the interaction is nickel-dependent, and that multiple consequences of frataxin deficiency are duplicated by ISD11 deficiency.	Iron	43-47	frataxin	Homo sapiens	24-32
17331979-12	2007	These data suggest that frataxin binds the iron-sulfur biogenesis Nfs1/ISCU complex through ISD11, that the interaction is nickel-dependent, and that multiple consequences of frataxin deficiency are duplicated by ISD11 deficiency.	Iron	43-47	NFS1 cysteine desulfurase	Homo sapiens	66-70
19751239-3	2009	Iron attenuation is countered through a pathway involving the hepatocyte-specific plasma membrane protease matriptase-2 encoded by TMPRSS6, leading to suppression of HAMP expression.	Iron	0-4	transmembrane serine protease 6	Mus musculus	107-119
17420293-2	2007	Endocytic sorting of the yeast reductive iron transporter, which is composed of the Fet3 and Ftr1 proteins, is regulated by available iron.	Iron	41-45	ferroxidase FET3	Saccharomyces cerevisiae S288C	84-88
16565419-2	2006	Hereditary hemochromatosis patients and Hfe-deficient mice show inappropriate expression of hepcidin but, in apparent contradiction, still retain the ability to regulate iron absorption in response to alterations of iron metabolism.	Iron	170-174	homeostatic iron regulator	Homo sapiens	40-43
16565419-2	2006	Hereditary hemochromatosis patients and Hfe-deficient mice show inappropriate expression of hepcidin but, in apparent contradiction, still retain the ability to regulate iron absorption in response to alterations of iron metabolism.	Iron	216-220	homeostatic iron regulator	Homo sapiens	40-43
17420293-3	2007	When iron is provided to iron-starved cells, Fet3p-Ftr1p is targeted to the lysosome-like vacuole and degraded.	Iron	5-9	ferroxidase FET3	Saccharomyces cerevisiae S288C	45-50
19751239-3	2009	Iron attenuation is countered through a pathway involving the hepatocyte-specific plasma membrane protease matriptase-2 encoded by TMPRSS6, leading to suppression of HAMP expression.	Iron	0-4	transmembrane serine protease 6	Mus musculus	131-138
17420293-3	2007	When iron is provided to iron-starved cells, Fet3p-Ftr1p is targeted to the lysosome-like vacuole and degraded.	Iron	25-29	ferroxidase FET3	Saccharomyces cerevisiae S288C	45-50
16841247-2	2006	Based on the observation that ectopic expression of HFE strongly inhibits apical iron uptake (Arredondo et al., 2001, FASEB J 15, 1276-1278), a negative regulation of HFE on the apical membrane transporter DMT1 was proposed as a mechanism by which HFE regulates iron absorption.	Iron	262-266	homeostatic iron regulator	Homo sapiens	167-170
17420293-4	2007	In contrast, when iron is not available, Fet3p-Ftr1p is maintained on the plasma membrane via an endocytic recycling pathway requiring the sorting nexin Grd19/Snx3p, the pentameric retromer complex, and the Ypt6p Golgi Rab GTPase module.	Iron	18-22	ferroxidase FET3	Saccharomyces cerevisiae S288C	41-46
19751239-7	2009	Mice lacking functional matriptase-2 and hemojuvelin exhibited low Hamp (Hamp1) expression, high serum and liver iron, and high transferrin saturation.	Iron	113-117	transmembrane serine protease 6	Mus musculus	24-36
16841247-3	2006	To test this hypothesis, we investigated: (i) the effect of HFE antisense oligonucleotides on apical iron uptake by polarized Caco-2 cells; (ii) the apical/basolateral membrane distribution of HFE, beta-2 microglobulin and DMT1; (iii) the putative molecular association between HFE and DMT1.	Iron	101-105	homeostatic iron regulator	Homo sapiens	60-63
16841247-4	2006	We found that HFE antisense treatment reduced HFE expression and increased apical iron uptake, whereas transfection with wild-type HFE inhibited iron uptake.	Iron	82-86	homeostatic iron regulator	Homo sapiens	14-17
16841247-5	2006	Thus, an inverse relationship was established between HFE levels and apical iron uptake activity.	Iron	76-80	homeostatic iron regulator	Homo sapiens	54-57
16841247-8	2006	The amount of HFE-beta2m in the apical membrane inversely correlated with apical iron uptake rates.	Iron	81-85	homeostatic iron regulator	Homo sapiens	14-17
16841247-10	2006	These results sustain a model by which direct interaction between DMT1 and HFE-beta2m in the apical membrane of Caco-2 cells result in down-regulation of apical iron uptake activity.	Iron	161-165	homeostatic iron regulator	Homo sapiens	75-78
17127713-8	2007	IRP1 coordinately controls the expression of transferrin receptor 1 (TfR1) and ferritin by binding to iron-responsive elements (IREs) within their mRNAs.	Iron	102-106	aconitase 1	Homo sapiens	0-4
17127713-8	2007	IRP1 coordinately controls the expression of transferrin receptor 1 (TfR1) and ferritin by binding to iron-responsive elements (IREs) within their mRNAs.	Iron	102-106	transferrin receptor	Homo sapiens	45-67
17127713-8	2007	IRP1 coordinately controls the expression of transferrin receptor 1 (TfR1) and ferritin by binding to iron-responsive elements (IREs) within their mRNAs.	Iron	102-106	transferrin receptor	Homo sapiens	69-73
17127713-10	2007	As expected, this response misregulated iron metabolism by increasing TfR1 levels.	Iron	40-44	transferrin receptor	Homo sapiens	70-74
16960437-0	2006	Cisplatin-induced expression of iron-retaining genes FIT2 and FIT3 in Saccharomyces cerevisiae.	Iron	32-36	Fit2p	Saccharomyces cerevisiae S288C	53-57
19884259-5	2009	Using the level of intracellular iron to regulate the translation of specific mRNAs, we show that translation promotes not only removal of EJC constituents, including the eIF4AIII anchor, but also replacement of PABPN1 by PABPC1.	Iron	33-37	eukaryotic translation initiation factor 4A3	Homo sapiens	171-179
16960437-1	2006	cDNA microarray analysis indicated that mRNA levels of Fit2p and Fit3p, proteins involved in iron retention within the yeast cell wall, were markedly increased by treatment of Saccharomyces cerevisiae with cisplatin.	Iron	93-97	Fit2p	Saccharomyces cerevisiae S288C	55-60
16673357-2	2006	FE-Pro labeling is non-toxic to cells; however, the effects of FE-Pro labeling on cellular expression of transferrin receptor (TfR-1) and ferritin, proteins involved in iron transport and storage, has not been reported.	Iron	169-173	transferrin receptor	Homo sapiens	105-125
17242182-0	2007	Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.	Iron	0-4	aconitase 1	Homo sapiens	34-38
17242182-1	2007	Iron regulatory protein 1 (IRP1) controls the translation or stability of several mRNAs by binding to "iron-responsive elements" within their untranslated regions.	Iron	103-107	aconitase 1	Homo sapiens	0-25
17242182-1	2007	Iron regulatory protein 1 (IRP1) controls the translation or stability of several mRNAs by binding to "iron-responsive elements" within their untranslated regions.	Iron	103-107	aconitase 1	Homo sapiens	27-31
17242182-2	2007	In iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster (ISC) that inhibits RNA-binding activity and converts the protein to cytosolic aconitase.	Iron	3-7	aconitase 1	Homo sapiens	23-27
17242182-2	2007	In iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster (ISC) that inhibits RNA-binding activity and converts the protein to cytosolic aconitase.	Iron	47-51	aconitase 1	Homo sapiens	23-27
17242182-3	2007	We show that the constitutive IRP1(C437S) mutant, which fails to form an ISC, is destabilized by iron.	Iron	97-101	aconitase 1	Homo sapiens	30-34
17242182-4	2007	Thus, exposure of H1299 cells to ferric ammonium citrate reduced the half-life of transfected IRP1(C437S) from approximately 24 h to approximately 10 h. The iron-dependent degradation of IRP1(C437S) involved ubiquitination, required ongoing transcription and translation, and could be efficiently blocked by the proteasomal inhibitors MG132 and lactacystin.	Iron	157-161	aconitase 1	Homo sapiens	94-98
19375516-1	2009	Hereditary hemochromatosis (HH) refers to a unique clinicopathologic subset of iron overload syndromes that includes the disorder related to C282Y homozygous mutation of the hemochromatosis protein (HFE), the most common form of hereditary hemochromatosis.	Iron	79-83	homeostatic iron regulator	Homo sapiens	199-202
17242182-4	2007	Thus, exposure of H1299 cells to ferric ammonium citrate reduced the half-life of transfected IRP1(C437S) from approximately 24 h to approximately 10 h. The iron-dependent degradation of IRP1(C437S) involved ubiquitination, required ongoing transcription and translation, and could be efficiently blocked by the proteasomal inhibitors MG132 and lactacystin.	Iron	157-161	aconitase 1	Homo sapiens	187-191
17242182-5	2007	Similar results were obtained with overexpressed wild-type IRP1, which predominated in the apo-form even in iron-loaded H1299 cells, possibly due to saturation of the ISC assembly machinery.	Iron	108-112	aconitase 1	Homo sapiens	59-63
17242182-6	2007	Importantly, inhibition of ISC biogenesis in HeLa cells by small interfering RNA knockdown of the cysteine desulfurase Nfs1 sensitized endogenous IRP1 for iron-dependent degradation.	Iron	155-159	NFS1 cysteine desulfurase	Homo sapiens	119-123
17242182-6	2007	Importantly, inhibition of ISC biogenesis in HeLa cells by small interfering RNA knockdown of the cysteine desulfurase Nfs1 sensitized endogenous IRP1 for iron-dependent degradation.	Iron	155-159	aconitase 1	Homo sapiens	146-150
16813577-7	2006	Further, transgenic frd4 plants accumulate FRO2-dHA fusion protein under iron-deficient conditions, suggesting that the frd4 mutation acts post-translationally in reducing Fe(III) chelate reductase activity.	Iron	73-77	signal recognition particle receptor protein, chloroplast (FTSY)	Arabidopsis thaliana	20-24
16813577-7	2006	Further, transgenic frd4 plants accumulate FRO2-dHA fusion protein under iron-deficient conditions, suggesting that the frd4 mutation acts post-translationally in reducing Fe(III) chelate reductase activity.	Iron	73-77	ferric reduction oxidase 2	Arabidopsis thaliana	43-47
16813577-7	2006	Further, transgenic frd4 plants accumulate FRO2-dHA fusion protein under iron-deficient conditions, suggesting that the frd4 mutation acts post-translationally in reducing Fe(III) chelate reductase activity.	Iron	73-77	signal recognition particle receptor protein, chloroplast (FTSY)	Arabidopsis thaliana	120-124
16813577-8	2006	FRO2-dHA appears to localize to the plasma membrane of root epidermal cells in both Col-0 and frd4-1 transgenic plants when grown under iron-deficient conditions.	Iron	136-140	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
16819888-10	2006	The ferric salicylate complexes display quasi-reversible reduction potentials from -89 to -551 mV (relative to the normal hydrogen electrode NHE) which supports the feasibility of a low pH iron release mechanism facilitated by biological reductants.	Iron	189-193	solute carrier family 9 member C1	Homo sapiens	141-144
17293870-0	2007	Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1.	Iron	30-34	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	67-95
19375516-4	2009	To-date, reviews on HFE C282Y HH have largely dealt with the end-stage consequence of this disorder (iron overload).	Iron	101-105	homeostatic iron regulator	Homo sapiens	20-23
17293870-2	2007	We have discovered a new mechanism to reverse iron overload-pharmacological modulation of the divalent metal transporter-1 (DMT-1).	Iron	46-50	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	94-122
17293870-2	2007	We have discovered a new mechanism to reverse iron overload-pharmacological modulation of the divalent metal transporter-1 (DMT-1).	Iron	46-50	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	124-129
17293870-3	2007	DMT-1 mediates intracellular iron transport during the transferrin cycle and apical iron absorption in the duodenum.	Iron	29-33	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-5
17293870-3	2007	DMT-1 mediates intracellular iron transport during the transferrin cycle and apical iron absorption in the duodenum.	Iron	84-88	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-5
17293870-5	2007	We show that the L-type calcium channel blocker nifedipine increases DMT-1-mediated cellular iron transport 10- to 100-fold at concentrations between 1 and 100 microM.	Iron	93-97	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	69-74
17293870-6	2007	Mechanistically, nifedipine causes this effect by prolonging the iron-transporting activity of DMT-1.	Iron	65-69	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	95-100
16824219-2	2006	Iron metabolism is associated with the gene hemochromatosis (HFE Human genome nomenclature committee ID:4886), and mutations in HFE are a cause of the iron mismetabolism disease, hemochromatosis.	Iron	0-4	homeostatic iron regulator	Homo sapiens	61-64
19693784-3	2009	A combination of lower pH, a chelator, inorganic anions, and the TFR leads to the efficient release of iron from each lobe.	Iron	103-107	transferrin receptor	Homo sapiens	65-68
16799786-3	2006	We have also shown that mice haploinsufficient for ATM develop cataracts earlier than wild-type animals, when exposed to either low-LET X-rays or high-LET (56)Fe ions.	Iron	159-161	ataxia telangiectasia mutated	Mus musculus	51-54
17316903-7	2007	These findings suggest a translational regulation of CP expression by iron in the cells.	Iron	70-74	ceruloplasmin	Rattus norvegicus	53-55
17316903-8	2007	We also examined the effects of CP on iron transport in the cells.	Iron	38-42	ceruloplasmin	Rattus norvegicus	32-34
17316903-10	2007	However, low concentrations of soluble CP (2-8 microg/ml) increased iron uptake by iron-deficient C6 glioma cells, while the same concentrations of CP had no effect on iron uptake by normal iron cells and iron release from normal iron and iron-sufficient cells.	Iron	68-72	ceruloplasmin	Rattus norvegicus	39-41
17316903-10	2007	However, low concentrations of soluble CP (2-8 microg/ml) increased iron uptake by iron-deficient C6 glioma cells, while the same concentrations of CP had no effect on iron uptake by normal iron cells and iron release from normal iron and iron-sufficient cells.	Iron	83-87	ceruloplasmin	Rattus norvegicus	39-41
17316903-10	2007	However, low concentrations of soluble CP (2-8 microg/ml) increased iron uptake by iron-deficient C6 glioma cells, while the same concentrations of CP had no effect on iron uptake by normal iron cells and iron release from normal iron and iron-sufficient cells.	Iron	83-87	ceruloplasmin	Rattus norvegicus	39-41
17316903-10	2007	However, low concentrations of soluble CP (2-8 microg/ml) increased iron uptake by iron-deficient C6 glioma cells, while the same concentrations of CP had no effect on iron uptake by normal iron cells and iron release from normal iron and iron-sufficient cells.	Iron	83-87	ceruloplasmin	Rattus norvegicus	39-41
17316903-10	2007	However, low concentrations of soluble CP (2-8 microg/ml) increased iron uptake by iron-deficient C6 glioma cells, while the same concentrations of CP had no effect on iron uptake by normal iron cells and iron release from normal iron and iron-sufficient cells.	Iron	83-87	ceruloplasmin	Rattus norvegicus	39-41
17316903-10	2007	However, low concentrations of soluble CP (2-8 microg/ml) increased iron uptake by iron-deficient C6 glioma cells, while the same concentrations of CP had no effect on iron uptake by normal iron cells and iron release from normal iron and iron-sufficient cells.	Iron	83-87	ceruloplasmin	Rattus norvegicus	39-41
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	89-91	solute carrier family 9 member C1	Homo sapiens	190-193
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	89-91	solute carrier family 9 member C1	Homo sapiens	248-251
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	89-91	solute carrier family 9 member C1	Homo sapiens	248-251
19720832-2	2009	Nfs1 is a highly conserved mitochondrial cysteine desulfurase that participates in iron-sulfur cluster assembly as a sulfur donor.	Iron	83-87	NFS1 cysteine desulfurase	Homo sapiens	0-4
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	141-143	solute carrier family 9 member C1	Homo sapiens	190-193
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	141-143	solute carrier family 9 member C1	Homo sapiens	248-251
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Iron	141-143	solute carrier family 9 member C1	Homo sapiens	248-251
17493330-15	2007	The coordinated expression regulation of these key iron metabolism-related molecules during cell differentiation may in turn inhibit TfR1-mediated iron uptake via endocytosis and thus adversely affect cell proliferation potential.	Iron	51-55	transferrin receptor	Homo sapiens	133-137
17493330-15	2007	The coordinated expression regulation of these key iron metabolism-related molecules during cell differentiation may in turn inhibit TfR1-mediated iron uptake via endocytosis and thus adversely affect cell proliferation potential.	Iron	147-151	transferrin receptor	Homo sapiens	133-137
19772341-1	2009	Irradiation of silicon-bridged [1]ferrocenophane [Fe(eta-C(5)H(4))(2)SiMe(2)] (1) in the presence of substitutionally labile Lewis bases such as 4,4"-dimethyl-2,2"-bipyridine (Me(2)bpy) initiates ring-opening polymerization and oligomerization via cleavage of an iron-cyclopentadienyl bond.	Iron	50-52	endothelin receptor type A	Homo sapiens	53-56
17877204-0	2007	[The expression of TfR1 mRNA and IRP1 mRNA in the placenta from different maternal iron status].	Iron	83-87	transferrin receptor	Homo sapiens	19-23
17877204-1	2007	OBJECTIVE: To investigate the mRNA expression of transferrin receptor 1 (TfR1) and iron regulatory protein 1 (IRP1) in the full-term placenta from different maternal iron status, and explore the mechanism of placental iron transport and regulation.	Iron	83-87	aconitase 1	Homo sapiens	110-114
17877204-1	2007	OBJECTIVE: To investigate the mRNA expression of transferrin receptor 1 (TfR1) and iron regulatory protein 1 (IRP1) in the full-term placenta from different maternal iron status, and explore the mechanism of placental iron transport and regulation.	Iron	166-170	transferrin receptor	Homo sapiens	49-71
17877204-1	2007	OBJECTIVE: To investigate the mRNA expression of transferrin receptor 1 (TfR1) and iron regulatory protein 1 (IRP1) in the full-term placenta from different maternal iron status, and explore the mechanism of placental iron transport and regulation.	Iron	166-170	transferrin receptor	Homo sapiens	73-77
17877204-1	2007	OBJECTIVE: To investigate the mRNA expression of transferrin receptor 1 (TfR1) and iron regulatory protein 1 (IRP1) in the full-term placenta from different maternal iron status, and explore the mechanism of placental iron transport and regulation.	Iron	166-170	aconitase 1	Homo sapiens	83-108
17877204-1	2007	OBJECTIVE: To investigate the mRNA expression of transferrin receptor 1 (TfR1) and iron regulatory protein 1 (IRP1) in the full-term placenta from different maternal iron status, and explore the mechanism of placental iron transport and regulation.	Iron	166-170	aconitase 1	Homo sapiens	110-114
17877204-7	2007	CONCLUSIONS: The expression of TfR1 mRNA is increased when maternal iron deficiency progressed while there is no change in the expression of IRP1 mRNA in the placentae of TfR1 mRNA indicated that IRP1 takes part in the regulation of placenta iron transport.	Iron	68-72	transferrin receptor	Homo sapiens	31-35
16611641-2	2006	In the present work, we utilize recombinant rat liver CDO and cysteine derivatives to elucidate structural parameters involved in substrate recognition and x-ray absorption spectroscopy to probe the interaction of the active site iron center with cysteine.	Iron	230-234	cysteine dioxygenase type 1	Rattus norvegicus	54-57
16627556-1	2006	Since the discovery of the hemochromatosis gene (HFE) in 1996, several novel gene defects have been detected, explaining the mechanism and diversity of iron-overload diseases.	Iron	152-156	homeostatic iron regulator	Homo sapiens	49-52
16680451-1	2006	Copper-zinc superoxide dismutase (SOD1) plays a protective role against the toxicity of superoxide, and studies in Saccharomyces cerevisiae and in Drosophila have suggested an additional role for SOD1 in iron metabolism.	Iron	204-208	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	34-38
19501056-2	2009	At cellular level, the maintenance of iron homeostasis is largely accomplished by the transferrin receptor (TfR-1) and by ferritin, whose expression is mainly regulated post-transcriptionally by iron regulatory proteins (IRPs).	Iron	38-42	transferrin receptor	Rattus norvegicus	86-106
16680451-1	2006	Copper-zinc superoxide dismutase (SOD1) plays a protective role against the toxicity of superoxide, and studies in Saccharomyces cerevisiae and in Drosophila have suggested an additional role for SOD1 in iron metabolism.	Iron	204-208	Superoxide dismutase 1	Drosophila melanogaster	196-200
17266924-1	2007	To deplete cellular iron uptake, and consequently inhibit the proliferation of tumor cells, we attempt to block surface expression of transferrin receptor (TfR) by intracellular antibody technology.	Iron	20-24	transferrin receptor	Homo sapiens	134-154
17266924-1	2007	To deplete cellular iron uptake, and consequently inhibit the proliferation of tumor cells, we attempt to block surface expression of transferrin receptor (TfR) by intracellular antibody technology.	Iron	20-24	transferrin receptor	Homo sapiens	156-159
17244611-0	2007	Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.	Iron	9-13	frataxin	Homo sapiens	120-128
19501056-2	2009	At cellular level, the maintenance of iron homeostasis is largely accomplished by the transferrin receptor (TfR-1) and by ferritin, whose expression is mainly regulated post-transcriptionally by iron regulatory proteins (IRPs).	Iron	38-42	transferrin receptor	Rattus norvegicus	108-113
17244611-0	2007	Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.	Iron	9-13	frataxin	Homo sapiens	138-142
17244611-0	2007	Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.	Iron	47-51	frataxin	Homo sapiens	120-128
16424395-2	2006	Thus, erythroblasts must modify the "standard" post-transcriptional feedback regulation, balancing expression of ferritin (Fer; iron storage) versus transferrin receptor (TfR1; iron uptake) via specific mRNA binding of iron regulatory proteins (IRPs).	Iron	177-181	transferrin receptor	Mus musculus	171-175
16424395-2	2006	Thus, erythroblasts must modify the "standard" post-transcriptional feedback regulation, balancing expression of ferritin (Fer; iron storage) versus transferrin receptor (TfR1; iron uptake) via specific mRNA binding of iron regulatory proteins (IRPs).	Iron	177-181	transferrin receptor	Mus musculus	171-175
17244611-0	2007	Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.	Iron	47-51	frataxin	Homo sapiens	138-142
19501056-9	2009	Our results indicate that estrogen level changes can regulate the binding activity of the IRP1, and consequently ferritin and TfR-1 expression in adipose tissue, suggesting a relationship among serum and tissue iron parameters, estrogen status and adiposity.	Iron	211-215	aconitase 1	Rattus norvegicus	90-94
17244611-0	2007	Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.	Iron	47-51	frataxin	Homo sapiens	120-128
17244611-0	2007	Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.	Iron	47-51	frataxin	Homo sapiens	138-142
16424395-8	2006	These and additional data stemming from inhibition of heme synthesis with succinylacetone or from iron overload suggest that highly efficient utilization of iron in mitochondrial heme synthesis during normal erythropoiesis alters the regulation of iron metabolism via the IRE/IRP system.	Iron	157-161	wingless-type MMTV integration site family, member 2	Mus musculus	276-279
16424395-8	2006	These and additional data stemming from inhibition of heme synthesis with succinylacetone or from iron overload suggest that highly efficient utilization of iron in mitochondrial heme synthesis during normal erythropoiesis alters the regulation of iron metabolism via the IRE/IRP system.	Iron	157-161	wingless-type MMTV integration site family, member 2	Mus musculus	276-279
17244611-1	2007	Frataxin, a small mitochondrial protein linked to the neurodegenerative disease Friedreich ataxia, has recently been proposed as an iron donor for the iron-sulfur cluster assembly.	Iron	132-136	frataxin	Homo sapiens	0-8
17244611-1	2007	Frataxin, a small mitochondrial protein linked to the neurodegenerative disease Friedreich ataxia, has recently been proposed as an iron donor for the iron-sulfur cluster assembly.	Iron	151-155	frataxin	Homo sapiens	0-8
17244611-3	2007	Here we have compared the iron binding property of IscA and the frataxin ortholog CyaY from Escherichia coli under physiological and oxidative stress conditions.	Iron	26-30	frataxin	Homo sapiens	82-86
17244611-4	2007	In the presence of the thioredoxin reductase system, which emulates the intracellular redox potential, CyaY fails to bind any iron even at a 10-fold excess of iron in the incubation solution.	Iron	159-163	frataxin	Homo sapiens	103-107
16527810-0	2006	Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.	Iron	92-96	NFS1 cysteine desulfurase	Homo sapiens	55-59
16527810-9	2006	When incubated with iron regulatory protein 1, cysteine, and iron, the cytosolic forms of ISCS and ISCU facilitated efficient formation of a [4Fe-4S] cluster on IRP1.	Iron	20-24	NFS1 cysteine desulfurase	Homo sapiens	90-94
16527810-9	2006	When incubated with iron regulatory protein 1, cysteine, and iron, the cytosolic forms of ISCS and ISCU facilitated efficient formation of a [4Fe-4S] cluster on IRP1.	Iron	20-24	aconitase 1	Homo sapiens	161-165
19501056-9	2009	Our results indicate that estrogen level changes can regulate the binding activity of the IRP1, and consequently ferritin and TfR-1 expression in adipose tissue, suggesting a relationship among serum and tissue iron parameters, estrogen status and adiposity.	Iron	211-215	transferrin receptor	Rattus norvegicus	126-131
16527810-10	2006	Thus, the cytosolic form of ISCS is a functional cysteine desulfurase that can collaborate with cytosolic ISCU to promote de novo iron-sulfur cluster formation.	Iron	130-134	NFS1 cysteine desulfurase	Homo sapiens	28-32
19761223-0	2009	Biophysical characterization of the iron in mitochondria from Atm1p-depleted Saccharomyces cerevisiae.	Iron	36-40	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	62-67
16634620-0	2006	A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase.	Iron	20-24	myo-inositol oxygenase	Homo sapiens	75-97
17360334-3	2007	Here, we describe the identification and characterization of an inhibitor of URO-D in liver cytosolic extracts from two murine models of PCT: wild-type mice treated with iron, delta-aminolevulinic acid, and polychlorinated biphenyls; and mice with one null allele of Uro-d and two null alleles of the hemochromatosis gene (Uro-d(+/-), Hfe(-/-)) that develop PCT with no treatments.	Iron	170-174	uroporphyrinogen decarboxylase	Mus musculus	77-82
17202145-1	2007	Transferrin receptor 2 (TfR2) is a homolog of transferrin receptor 1 (TfR1), the receptor responsible for the uptake of iron-loaded transferrin (holo-Tf) into cells.	Iron	120-124	transferrin receptor	Homo sapiens	46-68
16634620-1	2006	myo-Inositol oxygenase (MIOX) uses iron as its cofactor and dioxygen as its cosubstrate to effect the unique, ring-cleaving, four-electron oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate to d-glucuronate.	Iron	35-39	myo-inositol oxygenase	Homo sapiens	4-22
19761223-1	2009	Atm1p is an ABC transporter localized in the mitochondrial inner membrane; it functions to export an unknown species into the cytosol and is involved in cellular iron metabolism.	Iron	162-166	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	0-5
16634620-1	2006	myo-Inositol oxygenase (MIOX) uses iron as its cofactor and dioxygen as its cosubstrate to effect the unique, ring-cleaving, four-electron oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate to d-glucuronate.	Iron	35-39	myo-inositol oxygenase	Homo sapiens	24-28
17202145-1	2007	Transferrin receptor 2 (TfR2) is a homolog of transferrin receptor 1 (TfR1), the receptor responsible for the uptake of iron-loaded transferrin (holo-Tf) into cells.	Iron	120-124	transferrin receptor	Homo sapiens	70-74
17239470-3	2007	We have developed a mathematical model of the Tf/TfR trafficking cycle and have identified the Tf iron release rate as a previously unreported factor governing the degree of Tf cellular association.	Iron	98-102	transferrin receptor	Homo sapiens	49-52
19761223-2	2009	Depletion or deletion of Atm1p causes Fe accumulation in mitochondria and a defect in cytosolic Fe/S cluster assembly but reportedly not a defect in mitochondrial Fe/S cluster assembly.	Iron	38-40	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	25-30
17239470-9	2007	Thus, we show that inhibition of Tf iron release improves the efficacy of Tf as a drug carrier through increased association with cells expressing TfR.	Iron	36-40	transferrin receptor	Homo sapiens	147-150
19761223-7	2009	Atm1p-depleted mitochondria isolated from anaerobically grown cells exhibited WT levels of Fe/S clusters and hemes, and they did not hyperaccumulate Fe.	Iron	91-93	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	0-5
16540354-0	2006	Disparate phenotypic expression of ALAS2 R452H (nt 1407 G --&gt; A) in two brothers, one with severe sideroblastic anemia and iron overload, hepatic cirrhosis, and hepatocellular carcinoma.	Iron	126-130	5'-aminolevulinate synthase 2	Homo sapiens	35-40
16540354-3	2006	The proband"s brother, an ALAS2 R452H hemizygote, had mild anemia and mild iron overload.	Iron	75-79	5'-aminolevulinate synthase 2	Homo sapiens	26-31
19761223-10	2009	The Fe/S cluster defect and the Fe-accumulation phenotype, resulting from the depletion of Atm1p in aerobic cells (but not in anaerobic cells), may be secondary effects that are observed only when cells are exposed to oxygen during growth.	Iron	4-6	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	91-96
17121833-3	2007	Mammalian cells utilize transferrin-dependent mechanisms to acquire iron via transferrin receptors 1 and 2 (TfR1 and TfR2) by receptor-mediated endocytosis.	Iron	68-72	transferrin receptor	Homo sapiens	108-112
19465081-0	2009	Ferritin accumulation under iron scarcity in Drosophila iron cells.	Iron	28-32	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
17121859-7	2007	Under oxidizing conditions, the dimers would readily separate into iron-free active monomers, providing a structural explanation for glutaredoxin activation under oxidative stress.	Iron	67-71	glutaredoxin	Homo sapiens	133-145
16791740-1	2006	Human ATP-binding cassette, sub-family B, member 6 (ABCB6) is a mitochondrial ABC transporter, and presumably contributes to iron homeostasis.	Iron	125-129	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	52-57
19465081-0	2009	Ferritin accumulation under iron scarcity in Drosophila iron cells.	Iron	56-60	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
16885197-6	2007	We show here for the first time that heterozygote Apc mutation represents a strong selective advantage, via resistance to apoptosis induction (caspase 3 pathway), for colonic cells exposed to a haem-iron-induced lipoperoxidation.	Iron	199-203	APC regulator of WNT signaling pathway	Rattus norvegicus	50-53
16387364-8	2006	The data are consistent with a channeling model of Fe-trafficking in the Fet3p, Ftr1p complex and suggest that in this system, Fet3p serves as a redox sieve that presents Fe(III) specifically for permeation through Ftr1p.	Iron	51-53	ferroxidase FET3	Saccharomyces cerevisiae S288C	73-78
16885197-6	2007	We show here for the first time that heterozygote Apc mutation represents a strong selective advantage, via resistance to apoptosis induction (caspase 3 pathway), for colonic cells exposed to a haem-iron-induced lipoperoxidation.	Iron	199-203	caspase 3	Rattus norvegicus	143-152
19465081-1	2009	Ferritins are highly stable, multi-subunit protein complexes with iron-binding capacities that reach 4500 iron atoms per ferritin molecule.	Iron	66-70	Ferritin 1 heavy chain homologue	Drosophila melanogaster	121-129
17091493-1	2007	Transferrin receptors (Tfrc) are membrane bound glycoproteins which function to mediate cellular uptake of iron from transferrin.	Iron	107-111	transferrin receptor	Rattus norvegicus	0-21
16387364-8	2006	The data are consistent with a channeling model of Fe-trafficking in the Fet3p, Ftr1p complex and suggest that in this system, Fet3p serves as a redox sieve that presents Fe(III) specifically for permeation through Ftr1p.	Iron	51-53	ferroxidase FET3	Saccharomyces cerevisiae S288C	127-132
16518866-4	2006	In K(3)Fe(CN)(6) , the SAMs show a strong electron-transfer (ET) blocking effect on a pure porphyrin-modified electrode.	Iron	7-9	methionine adenosyltransferase 1A	Homo sapiens	23-27
17091493-1	2007	Transferrin receptors (Tfrc) are membrane bound glycoproteins which function to mediate cellular uptake of iron from transferrin.	Iron	107-111	transferrin receptor	Rattus norvegicus	23-27
19465081-1	2009	Ferritins are highly stable, multi-subunit protein complexes with iron-binding capacities that reach 4500 iron atoms per ferritin molecule.	Iron	106-110	Ferritin 1 heavy chain homologue	Drosophila melanogaster	121-129
17091493-8	2007	It is suggested that Tfrc are required for uptake of iron for cell proliferation and maturation in the pineal gland upto 6 weeks of age.	Iron	53-57	transferrin receptor	Rattus norvegicus	21-25
17091493-12	2007	It is concluded that increased expression of Tfrc in response to hypoxia leads to excess cellular uptake of iron which may be damaging to the cells.	Iron	108-112	transferrin receptor	Rattus norvegicus	45-49
19465081-3	2009	The insect intestine has long been known to contain cells that are responsive to dietary iron levels and a specialized group of "iron cells" that always accumulate iron-loaded ferritin, even when no supplementary iron is added to the diet.	Iron	129-133	Ferritin 1 heavy chain homologue	Drosophila melanogaster	176-184
19465081-3	2009	The insect intestine has long been known to contain cells that are responsive to dietary iron levels and a specialized group of "iron cells" that always accumulate iron-loaded ferritin, even when no supplementary iron is added to the diet.	Iron	129-133	Ferritin 1 heavy chain homologue	Drosophila melanogaster	176-184
19465081-3	2009	The insect intestine has long been known to contain cells that are responsive to dietary iron levels and a specialized group of "iron cells" that always accumulate iron-loaded ferritin, even when no supplementary iron is added to the diet.	Iron	129-133	Ferritin 1 heavy chain homologue	Drosophila melanogaster	176-184
17229907-2	2007	NGAL exerts bacteriostatic effects, which are explained by its ability to capture and deplete siderophores, small iron-binding molecules that are synthesized by certain bacteria as a means of iron acquisition.	Iron	114-118	lipocalin 2	Mus musculus	0-4
17229907-2	2007	NGAL exerts bacteriostatic effects, which are explained by its ability to capture and deplete siderophores, small iron-binding molecules that are synthesized by certain bacteria as a means of iron acquisition.	Iron	192-196	lipocalin 2	Mus musculus	0-4
19465081-4	2009	Here, we further characterize ferritin localization in Drosophila melanogaster larvae raised under iron-enriched and iron-depleted conditions.	Iron	99-103	Ferritin 1 heavy chain homologue	Drosophila melanogaster	30-38
17229907-5	2007	NGAL acts as a growth and differentiation factor in multiple cell types, including developing and mature renal epithelia, and some of this activity is enhanced in the presence of siderophore:iron complexes.	Iron	191-195	lipocalin 2	Mus musculus	0-4
17229907-7	2007	Accordingly, NGAL-mediated iron shuttling between the extracellular and intracellular spaces may explain some of the biologic activities of the protein.	Iron	27-31	lipocalin 2	Mus musculus	13-17
19465081-4	2009	Here, we further characterize ferritin localization in Drosophila melanogaster larvae raised under iron-enriched and iron-depleted conditions.	Iron	117-121	Ferritin 1 heavy chain homologue	Drosophila melanogaster	30-38
17229907-9	2007	This review summarizes the current knowledge about the dual effects of NGAL as a siderophore:iron-binding protein and as a growth factor and examines the role of these effects in renal injury.	Iron	93-97	lipocalin 2	Mus musculus	71-75
19465081-5	2009	High dietary iron intake results in ferritin accumulation in the anterior midgut, but also in garland (wreath) cells and in pericardial cells, which together filter the circulating hemolymph.	Iron	13-17	Ferritin 1 heavy chain homologue	Drosophila melanogaster	36-44
19465081-6	2009	Ferritin is also abundant in the brain, where levels remain unaltered following dietary iron chelation, a treatment that depletes ferritin from the aforementioned tissues.	Iron	88-92	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
19465081-6	2009	Ferritin is also abundant in the brain, where levels remain unaltered following dietary iron chelation, a treatment that depletes ferritin from the aforementioned tissues.	Iron	88-92	Ferritin 1 heavy chain homologue	Drosophila melanogaster	130-138
19465081-7	2009	We attribute the stability of ferritin levels in the brain to the function of the blood-brain barrier that may shield this organ from systemic iron fluctuations.	Iron	143-147	Ferritin 1 heavy chain homologue	Drosophila melanogaster	30-38
17204047-8	2007	Finally, for most combinations of prevalence and penetrance of HFE, one screening algorithm--unbound iron-binding capacity + transferrin saturation--appeared robust enough to be always within the top 5 most cost-effective strategies.	Iron	101-105	homeostatic iron regulator	Homo sapiens	63-66
19465081-9	2009	Therefore, insect iron cells may constitute an exception from the evolutionary norm with respect to iron-dependent ferritin regulation.	Iron	18-22	Ferritin 1 heavy chain homologue	Drosophila melanogaster	115-123
19465081-9	2009	Therefore, insect iron cells may constitute an exception from the evolutionary norm with respect to iron-dependent ferritin regulation.	Iron	100-104	Ferritin 1 heavy chain homologue	Drosophila melanogaster	115-123
19465081-10	2009	It will be of interest to decipher both the physiological purpose served and the mechanism employed to untie ferritin regulation from cellular iron levels in this cell type.	Iron	143-147	Ferritin 1 heavy chain homologue	Drosophila melanogaster	109-117
17546681-5	2007	All 25 genes showed altered expression during the period of ID (P7, 15, and 30); 10 had changes on P65 after iron repletion.	Iron	109-113	RELA proto-oncogene, NF-kB subunit	Homo sapiens	99-102
19460456-5	2009	Finally, we recently reported that Friedreich"s Ataxia (FA) patients and carriers can be identified on the basis of a simple dipstick test to measure levels of a single protein, frataxin, an iron regulatory protein whose disrupted expression is the proximal cause of neurodegeneration in FA.	Iron	191-195	frataxin	Homo sapiens	178-186
17474269-0	2007	HFE mutation H63D predicts risk of iron over load in thalassemia intermedia irrespective of blood transfusions.	Iron	35-39	homeostatic iron regulator	Homo sapiens	0-3
17474269-3	2007	Since, HFE gene is associated with iron overload; the present study was conducted in an attempt to evaluate its role in thalassemia intermedia.	Iron	35-39	homeostatic iron regulator	Homo sapiens	7-10
17474269-12	2007	Thus, it is concluded that thalassemia intermedia patients with co-existent HFE mutation have a higher likelihood of developing iron overload and may require early iron chelation.	Iron	128-132	homeostatic iron regulator	Homo sapiens	76-79
19861554-2	2009	Ferroportin (FPN) is the sole iron efflux transporter identified to date in animals, and there are two closely related orthologs in Arabidopsis thaliana, IRON REGULATED1 (IREG1/FPN1) and IREG2/FPN2.	Iron	154-158	iron regulated 2	Arabidopsis thaliana	187-192
17474269-12	2007	Thus, it is concluded that thalassemia intermedia patients with co-existent HFE mutation have a higher likelihood of developing iron overload and may require early iron chelation.	Iron	164-168	homeostatic iron regulator	Homo sapiens	76-79
17236123-1	2007	It is hypothesized that a homozygous C282Y mutation of the HFE gene prohibits the assembly of the transferrin-receptor 1 (TFR1) with the divalent metal transporter (DMT1) as the main iron update complex in hepatocytes membrane.	Iron	183-187	homeostatic iron regulator	Homo sapiens	59-62
17236123-1	2007	It is hypothesized that a homozygous C282Y mutation of the HFE gene prohibits the assembly of the transferrin-receptor 1 (TFR1) with the divalent metal transporter (DMT1) as the main iron update complex in hepatocytes membrane.	Iron	183-187	transferrin receptor	Homo sapiens	98-120
17236123-1	2007	It is hypothesized that a homozygous C282Y mutation of the HFE gene prohibits the assembly of the transferrin-receptor 1 (TFR1) with the divalent metal transporter (DMT1) as the main iron update complex in hepatocytes membrane.	Iron	183-187	transferrin receptor	Homo sapiens	122-126
19861554-2	2009	Ferroportin (FPN) is the sole iron efflux transporter identified to date in animals, and there are two closely related orthologs in Arabidopsis thaliana, IRON REGULATED1 (IREG1/FPN1) and IREG2/FPN2.	Iron	154-158	iron regulated 2	Arabidopsis thaliana	193-197
19608791-0	2009	Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3beta pathway in synaptic endings from adult and aged rats.	Iron	0-4	glycogen synthase kinase 3 beta	Rattus norvegicus	64-72
17173408-7	2006	The enhancement of the peroxidase activity and the formation of the stable compound III in myoglobin with iron porphycene mainly arise from the strong coordination of the Fe-His93 bond.	Iron	171-173	myoglobin	Physeter catodon	91-100
19608791-1	2009	In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and aged (28-month-old) rats.	Iron	169-173	glycogen synthase kinase 3 beta	Rattus norvegicus	65-96
19608791-1	2009	In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and aged (28-month-old) rats.	Iron	169-173	glycogen synthase kinase 3 beta	Rattus norvegicus	107-115
19608791-9	2009	We demonstrate here that synaptic endings from adult and aged animals subjected to iron-induced neurotoxicity show a differential profile in the activation of PI3K/Akt/GSK3beta.	Iron	83-87	glycogen synthase kinase 3 beta	Rattus norvegicus	168-176
17145987-3	2006	The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity.	Iron	74-78	homeostatic iron regulator	Homo sapiens	44-47
19290777-4	2009	Although monothiol glutathione-dependent oxidoreductases (Grxs) have previously been demonstrated to be involved in iron-sulfur (Fe-S) center biogenesis, including that in yeast, here we report data suggesting the involvement of mitochondrial Grx2, a dithiol Grx, in iron-sulfur biogenesis in a mammalian dopaminergic cell line.	Iron	116-120	dithiol glutaredoxin GRX2	Saccharomyces cerevisiae S288C	243-247
17145987-4	2006	Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system.	Iron	65-69	homeostatic iron regulator	Homo sapiens	4-7
19487139-2	2009	HFE binds to the transferrin receptor-1 (TfR1) in competition with iron-loaded transferrin (Fe-Tf).	Iron	67-71	homeostatic iron regulator	Homo sapiens	0-3
17416047-5	2006	The control of intracellular iron content is under the dependence of the IRE/IRP system which modulates cellular iron ingress and storage.	Iron	29-33	Wnt family member 2	Homo sapiens	77-80
17416047-5	2006	The control of intracellular iron content is under the dependence of the IRE/IRP system which modulates cellular iron ingress and storage.	Iron	113-117	Wnt family member 2	Homo sapiens	77-80
17416049-1	2006	HFE-linked, or type 1, hemochromatosis is by far, in the causasians, the most frequent form of chronic iron overload of genetic origin.	Iron	103-107	homeostatic iron regulator	Homo sapiens	0-3
19487139-3	2009	HFE is released from TfR1 by increasing concentrations of Fe-Tf, and free HFE may then regulate iron homeostasis by binding other ligands.	Iron	96-100	homeostatic iron regulator	Homo sapiens	74-77
19487139-10	2009	HFE bound to TfR1 was prevented from binding CI-MPR until released by increasing concentrations of Fe-Tf, a feature consistent with an iron sensing mechanism.	Iron	99-101	homeostatic iron regulator	Homo sapiens	0-3
19487139-10	2009	HFE bound to TfR1 was prevented from binding CI-MPR until released by increasing concentrations of Fe-Tf, a feature consistent with an iron sensing mechanism.	Iron	99-101	transferrin receptor	Homo sapiens	13-17
17181889-8	2006	After Fe supplementation, the level of sTfR was significantly decreased in children with IDs, but not in children with IDE and IDA, while TfR-F index was significantly decreased in Fe-deficient children.	Iron	6-8	transferrin receptor	Homo sapiens	40-43
19487139-10	2009	HFE bound to TfR1 was prevented from binding CI-MPR until released by increasing concentrations of Fe-Tf, a feature consistent with an iron sensing mechanism.	Iron	135-139	homeostatic iron regulator	Homo sapiens	0-3
19487139-10	2009	HFE bound to TfR1 was prevented from binding CI-MPR until released by increasing concentrations of Fe-Tf, a feature consistent with an iron sensing mechanism.	Iron	135-139	transferrin receptor	Homo sapiens	13-17
19482077-7	2009	The administration of an iron complex, a free radical generator, induced GSTA4 expression in wild-type mouse kidneys.	Iron	25-29	glutathione S-transferase, alpha 4	Mus musculus	73-78
17116244-0	2006	Huntingtin inclusion bodies are iron-dependent centers of oxidative events.	Iron	32-36	huntingtin	Homo sapiens	0-10
19482077-8	2009	Iron deposition detected in SOD1 KO mouse kidney is thought to be an inducer of GSTA4.	Iron	0-4	glutathione S-transferase, alpha 4	Mus musculus	80-85
19669241-1	2009	There have been major developments in the field of iron metabolism in the past decade following the identification of the HFE gene and the mutation responsible for the C282Y substitution in the HFE protein.	Iron	51-55	homeostatic iron regulator	Homo sapiens	122-125
17303462-0	2006	[HFE gene mutations in Tunisian major beta-Thalassemia and iron overload].	Iron	59-63	homeostatic iron regulator	Homo sapiens	1-4
17185172-1	2006	For studying the effects of endogenous ferritin gene expressions (NtFer1, GenBank accession number AY083924; and NtFer2, GenBank accession number AY141105) on the iron homeostasis in transgenic tobacco (Nicotiana tabacum L.) plants expressing soybean (Glycine max Merr) ferritin gene (SoyFer1, GenBank accession number M64337), the transgenic tobacco has been produced by placing soybean ferritin cDNA cassette under the control of the CaMV 35S promoter.	Iron	163-167	ferritin-2, chloroplastic	Nicotiana tabacum	113-119
19669241-1	2009	There have been major developments in the field of iron metabolism in the past decade following the identification of the HFE gene and the mutation responsible for the C282Y substitution in the HFE protein.	Iron	51-55	homeostatic iron regulator	Homo sapiens	194-197
27683335-5	2009	The importance of genetic risk factors in relation to iron overload was highlighted with the identification of the HFE gene in 1996.	Iron	54-58	homeostatic iron regulator	Homo sapiens	115-118
17162256-9	2006	The IRP/IRE (iron regulatory protein/iron responsive element) system controls cellular uptake, stores and exportation of iron, and heme synthesis.	Iron	13-17	Wnt family member 2	Homo sapiens	4-7
17162256-9	2006	The IRP/IRE (iron regulatory protein/iron responsive element) system controls cellular uptake, stores and exportation of iron, and heme synthesis.	Iron	37-41	Wnt family member 2	Homo sapiens	4-7
17162256-9	2006	The IRP/IRE (iron regulatory protein/iron responsive element) system controls cellular uptake, stores and exportation of iron, and heme synthesis.	Iron	37-41	Wnt family member 2	Homo sapiens	4-7
17114340-1	2006	Lipocalin 2 is an iron-binding secreted protein that converts embryonic kidney mesenchyme to epithelia.	Iron	18-22	lipocalin 2	Mus musculus	0-11
19454487-1	2009	The LYR family consists of proteins of diverse functions that contain the conserved tripeptide "LYR" near the N-terminus, and it includes Isd11, which was previously observed to have an important role in iron-sulfur (Fe-S) cluster biogenesis in Saccharomyces cerevisiae.	Iron	217-221	Isd11p	Saccharomyces cerevisiae S288C	138-143
16905747-2	2006	Nramp2 (DMT1, Slc11a2) is expressed both at the duodenal brush border where it mediates uptake of dietary iron and ubiquitously at the plasma membrane/recycling endosomes of many cell types where it transports transferrin-associated iron across the endosomal membrane.	Iron	106-110	solute carrier family 11 member 2	Sus scrofa	8-12
19454487-2	2009	Here, we have cloned and characterized human ISD11 and shown that human ISD11 forms a stable complex in vivo with the human cysteine desulfurase (ISCS), which generates the inorganic sulfur needed for Fe-S protein biogenesis.	Iron	201-205	NFS1 cysteine desulfurase	Homo sapiens	146-150
16905747-2	2006	Nramp2 (DMT1, Slc11a2) is expressed both at the duodenal brush border where it mediates uptake of dietary iron and ubiquitously at the plasma membrane/recycling endosomes of many cell types where it transports transferrin-associated iron across the endosomal membrane.	Iron	106-110	solute carrier family 11 member 2	Sus scrofa	14-21
19454487-5	2009	In addition, ISD11 suppression activated iron-responsive element-binding activity of iron regulatory protein 1, increased protein levels of iron regulatory protein 2, and resulted in abnormal punctate ferric iron accumulations in cells.	Iron	41-45	aconitase 1	Homo sapiens	85-110
16905747-2	2006	Nramp2 (DMT1, Slc11a2) is expressed both at the duodenal brush border where it mediates uptake of dietary iron and ubiquitously at the plasma membrane/recycling endosomes of many cell types where it transports transferrin-associated iron across the endosomal membrane.	Iron	233-237	solute carrier family 11 member 2	Sus scrofa	8-12
16905747-2	2006	Nramp2 (DMT1, Slc11a2) is expressed both at the duodenal brush border where it mediates uptake of dietary iron and ubiquitously at the plasma membrane/recycling endosomes of many cell types where it transports transferrin-associated iron across the endosomal membrane.	Iron	233-237	solute carrier family 11 member 2	Sus scrofa	14-21
16565443-4	2006	Postischemic hearts from iron-loaded rats also exhibited 5.6-, 3.48-, 2.43-, and 3.45-fold increases in total effluent iron content, conjugated diene levels, lactate dehydrogenase (LDH) activity, and lysosomal N-acetyl-beta-glucosaminidase (NAGA) activity, respectively, compared with similarly stressed non-loaded hearts.	Iron	25-29	O-GlcNAcase	Rattus norvegicus	210-239
16565443-4	2006	Postischemic hearts from iron-loaded rats also exhibited 5.6-, 3.48-, 2.43-, and 3.45-fold increases in total effluent iron content, conjugated diene levels, lactate dehydrogenase (LDH) activity, and lysosomal N-acetyl-beta-glucosaminidase (NAGA) activity, respectively, compared with similarly stressed non-loaded hearts.	Iron	25-29	O-GlcNAcase	Rattus norvegicus	241-245
19538181-6	2009	Mutant Zrc1 that gained iron transport activity could protect cells with a deletion in the vacuolar iron transporter (CCC1) from high iron toxicity.	Iron	24-28	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	7-11
16174659-0	2006	Iron loading and morbidity among relatives of HFE C282Y homozygotes identified either by population genetic testing or presenting as patients.	Iron	0-4	homeostatic iron regulator	Homo sapiens	46-49
16174659-12	2006	CONCLUSIONS: HFE C282Y homozygosity has a high penetrance for iron accumulation but a low clinical penetrance.	Iron	62-66	homeostatic iron regulator	Homo sapiens	13-16
16926153-4	2006	Reduced levels of the V-ATPase lead to defective copper loading of Fet3p, a component of the high affinity iron transport system.	Iron	107-111	ferroxidase FET3	Saccharomyces cerevisiae S288C	67-72
16989817-3	2006	Frataxin plays a crucial role in iron metabolism and detoxification.	Iron	33-37	frataxin	Homo sapiens	0-8
19538181-6	2009	Mutant Zrc1 that gained iron transport activity could protect cells with a deletion in the vacuolar iron transporter (CCC1) from high iron toxicity.	Iron	100-104	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	7-11
19538181-7	2009	Utilizing suppression of high iron toxicity and PCR mutagenesis of ZRC1, we identified other amino acid substitutions within ZRC1 that changed its metal specificity.	Iron	30-34	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	125-129
16539659-6	2006	The finding that Fe(2)SO(4) reversed the action of EGCG on APP and TfR proteins reinforces the likelihood that these effects are mediated through modulation of the intracellular iron pool.	Iron	178-182	transferrin receptor	Homo sapiens	67-70
19542342-0	2009	Kinetic characterization of OmcA and MtrC, terminal reductases involved in respiratory electron transfer for dissimilatory iron reduction in Shewanella oneidensis MR-1.	Iron	123-127	OmcA/MtrC family decaheme c-type cytochrome	Shewanella oneidensis MR-1	37-41
16522801-8	2006	Together with two iron-binding residues (His49 and Glu55), Asp120, Asn51, Glu111, and Arg114 form a hydrogen-bonding network; this hydrogen-bond network is key to the catalysis of 3HAO.	Iron	18-22	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	180-184
17010238-2	2006	The workshop concluded that individuals who are heterozygous for the C282Y mutation of the HFE gene do not appear to respond abnormally to dietary Fe and therefore do not need to change their diet to prevent accumulation of body Fe.	Iron	229-231	homeostatic iron regulator	Homo sapiens	91-94
16999731-3	2006	Further investigations revealed two distinct genetic mutations of iron haemostasis--homozygosity for C282Y mutation of the HFE gene on chromosome 6 and heterozygosity for A40G mutation in the iron response element of ferritin light chain on chromosome 19.	Iron	66-70	homeostatic iron regulator	Homo sapiens	123-126
19542342-1	2009	We have used scaling kinetics and the concept of kinetic competence to elucidate the role of hemeproteins OmcA and MtrC in iron reduction by Shewanella oneidensis MR-1.	Iron	123-127	OmcA/MtrC family decaheme c-type cytochrome	Shewanella oneidensis MR-1	115-119
19542342-9	2009	Therefore, we show for the first time that OmcA and MtrC are kinetically competent to account for catalysis of soluble iron reduction in whole Shewanella cells but are not responsible for electron transfer via direct contact alone with insoluble iron-containing minerals.	Iron	119-123	OmcA/MtrC family decaheme c-type cytochrome	Shewanella oneidensis MR-1	52-56
19542342-9	2009	Therefore, we show for the first time that OmcA and MtrC are kinetically competent to account for catalysis of soluble iron reduction in whole Shewanella cells but are not responsible for electron transfer via direct contact alone with insoluble iron-containing minerals.	Iron	246-250	OmcA/MtrC family decaheme c-type cytochrome	Shewanella oneidensis MR-1	52-56
16455651-7	2006	We have also demonstrated for the first time that endogenous Fes is strongly expressed at the base of colonic crypts where it co-localizes with epithelial cells positive for the progenitor cell marker Musashi-1.	Iron	61-64	musashi RNA binding protein 1	Homo sapiens	201-210
16741749-3	2006	Like other dicotyledonous plants, soybean responds to iron-limiting environments by induction of an active proton pump, a ferric iron reductase and an iron transporter.	Iron	54-58	chalcone reductase CHR1	Glycine max	134-143
16741749-7	2006	The enhanced ferric reductase activity led to reduced chlorosis, increased chlorophyll concentration and a lessening in biomass loss in the transgenic events between Fe treatments as compared to control plants grown under hydroponics that mimicked Fe-sufficient and Fe-deficient soil environments.	Iron	166-168	chalcone reductase CHR1	Glycine max	20-29
16741749-7	2006	The enhanced ferric reductase activity led to reduced chlorosis, increased chlorophyll concentration and a lessening in biomass loss in the transgenic events between Fe treatments as compared to control plants grown under hydroponics that mimicked Fe-sufficient and Fe-deficient soil environments.	Iron	248-250	chalcone reductase CHR1	Glycine max	20-29
16431909-1	2006	The specialized yeast mitochondrial chaperone system, composed of the Hsp70 Ssq1p, its co-chaperone J-protein Jac1p, and the nucleotide release factor Mge1p, perform a critical function in the biogenesis of iron-sulfur (Fe/S) proteins.	Iron	220-222	Mge1p	Saccharomyces cerevisiae S288C	151-156
16741749-7	2006	The enhanced ferric reductase activity led to reduced chlorosis, increased chlorophyll concentration and a lessening in biomass loss in the transgenic events between Fe treatments as compared to control plants grown under hydroponics that mimicked Fe-sufficient and Fe-deficient soil environments.	Iron	248-250	chalcone reductase CHR1	Glycine max	20-29
16431909-3	2006	In the absence of chaperones, the kinetics of Fe/S cluster formation on Isu1p were compatible with a chemical reconstitution pathway with Nfs1p functioning as a sulfide donor.	Iron	46-48	NFS1 cysteine desulfurase	Homo sapiens	138-143
16741749-8	2006	However, the data indicate that constitutive FRO2 expression under non-iron stress conditions may lead to a decrease in plant productivity as reflected by reduced biomass accumulation in the transgenic events under non-iron stress conditions.	Iron	71-75	ferric reduction oxidase 2	Arabidopsis thaliana	45-49
19656484-3	2009	Several are implicated in iron-sulfur cluster biogenesis, and malfunction of these genes may repress heme synthesis by activating the IRE/IRP posttranscriptional regulatory system.	Iron	26-30	Wnt family member 2	Homo sapiens	138-141
16741749-8	2006	However, the data indicate that constitutive FRO2 expression under non-iron stress conditions may lead to a decrease in plant productivity as reflected by reduced biomass accumulation in the transgenic events under non-iron stress conditions.	Iron	219-223	ferric reduction oxidase 2	Arabidopsis thaliana	45-49
19731715-7	2009	The gene encoding the multicopper ferroxidase FET3, part of the high-affinity iron uptake system, was also induced in all treatments, along with the STR3 gene, which codes for the cystathionine beta-lyase found in the methionine biosynthetic pathway.	Iron	78-82	ferroxidase FET3	Saccharomyces cerevisiae S288C	46-50
17027502-0	2006	The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron.	Iron	97-101	frataxin	Homo sapiens	18-26
17027502-2	2006	Here, we present the crystal structures of the iron-free and iron-loaded frataxin trimers, and a single-particle electron microscopy reconstruction of a 24 subunit oligomer.	Iron	61-65	frataxin	Homo sapiens	73-81
16467350-0	2006	The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.	Iron	108-112	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	51-56
16414021-6	2006	These results indicate that HFE could be considered a candidate modifier gene of viral-related neoplasia such as cervical carcinoma possibly by a dual role on iron metabolism and immunological system.	Iron	159-163	homeostatic iron regulator	Homo sapiens	28-31
19308466-0	2009	Iron-sulfur cluster biosynthesis: characterization of IscU-IscS complex formation and a structural model for sulfide delivery to the [2Fe-2S] assembly site.	Iron	0-4	NFS1 cysteine desulfurase	Homo sapiens	59-63
16706076-6	2006	The hemochromatosis HFE gen evaluation showed heterozigotus character mutations (H63D and C282Y) a frequent association in patients with iron overload and PCT.	Iron	137-141	homeostatic iron regulator	Homo sapiens	20-23
16706076-9	2006	The mutation of the gen HFE in our patient and the hemolysis caused by ribavirin can be related to the development of the disease, but the iron overload because of ribavirin use is also controversial.	Iron	139-143	homeostatic iron regulator	Homo sapiens	24-27
16878186-0	2006	Analysis of HFE gene mutations and HLA-A alleles in Brazilian patients with iron overload.	Iron	76-80	homeostatic iron regulator	Homo sapiens	12-15
17002922-1	2006	Homozygosity for the C282Y mutation of the hemochromatosis gene on chromosome 6p (HFE) is a common genetic trait that increases susceptibility to iron overload.	Iron	146-150	homeostatic iron regulator	Homo sapiens	82-85
16893896-0	2006	Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.	Iron	126-130	homeostatic iron regulator	Homo sapiens	36-39
16893896-1	2006	HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis.	Iron	82-86	homeostatic iron regulator	Homo sapiens	0-3
16878186-2	2006	The objective was to analyze the presence of C282Y, H63D and S65C mutations in the HFE gene and HLA-A alleles for a group of Brazilian patients with iron overload, and to correlate genotype with clinical and laboratory variables.	Iron	149-153	homeostatic iron regulator	Homo sapiens	83-86
16878186-11	2006	CONCLUSION: Analysis of HFE gene mutations constitutes an important procedure in identifying patients with hereditary hemochromatosis, particularly for patients with iron overload.	Iron	166-170	homeostatic iron regulator	Homo sapiens	24-27
19373496-1	2009	Recent crystal structures of cysteine dioxygenase (CDO) suggest the presence of two posttranslational modifications adjacent to the catalytic iron center: a thioether cross-link between Cys93 and Tyr157 and extra electron density at Cys164 which was variously explained as cystine or cysteine sulfinic acid.	Iron	142-146	cysteine dioxygenase type 1	Rattus norvegicus	29-49
16509978-0	2006	A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.	Iron	169-173	homeostatic iron regulator	Homo sapiens	41-44
16873371-13	2006	This provides a rationale for the regulation of hmp expression by the transcriptional repressor NsrR in response to both nitrosative stress and intracellular free iron concentration.	Iron	163-167	inner membrane protein, mitochondrial	Mus musculus	48-51
16873371-14	2006	The Hmp flavohemoglobin plays a central role in the response of Salmonella to nitrosative stress but requires precise regulation to avoid the exacerbation of oxidative stress that can result if electrons are shuttled to extraneous iron.	Iron	231-235	inner membrane protein, mitochondrial	Mus musculus	4-7
19373496-1	2009	Recent crystal structures of cysteine dioxygenase (CDO) suggest the presence of two posttranslational modifications adjacent to the catalytic iron center: a thioether cross-link between Cys93 and Tyr157 and extra electron density at Cys164 which was variously explained as cystine or cysteine sulfinic acid.	Iron	142-146	cysteine dioxygenase type 1	Rattus norvegicus	51-54
16517407-1	2006	Iron-sulfur (Fe-S) clusters are required for the functions of mitochondrial aconitase, mammalian iron regulatory protein 1, and many other proteins in multiple subcellular compartments.	Iron	13-17	aconitase 1	Homo sapiens	97-122
16787388-1	2006	The neurodegenerative disorder FRDA (Friedreich"s ataxia) results from a deficiency in frataxin, a putative iron chaperone, and is due to the presence of a high number of GAA repeats in the coding regions of both alleles of the frataxin gene, which impair protein expression.	Iron	108-112	frataxin	Homo sapiens	87-95
19473966-4	2009	Unlike HO-1, which lacks cysteine residues, HO-2 contains three Cys-Pro signatures, known as heme regulatory motifs (HRMs), which are known to control processes related to iron and oxidative metabolism in organisms from bacteria to humans.	Iron	172-176	heme oxygenase 2	Homo sapiens	44-48
16537044-4	2006	Screening for HFE mutations among certain patient groups, including patients with cirrhosis, however, may help target those who would benefit most from iron removal.	Iron	152-156	homeostatic iron regulator	Homo sapiens	14-17
19453295-11	2009	RNA interference of the putative Drosophila orthologue of human ABCB7, a mitochondrial transporter involved in cytoplasmic ISC protein maturation, restored Fer1HCH transcript levels of iron-treated mbn-dmfrn cells to those of control cells grown in normal medium.	Iron	185-189	Ferritin 1 heavy chain homologue	Drosophila melanogaster	156-163
16933946-19	2006	A series of isotope-labeling experiments has been carried out, and the modes with the greatest metal-nitrogen stretching character have been assigned to peaks at approximately 960 and approximately 1300 cm(-1) in both the iron and cobalt [PhBP3]MNPh complexes.	Iron	222-226	PHB1 pseudogene 3	Homo sapiens	239-244
16208485-1	2006	The haemochromatosis protein (HFE) is an important regulator of body iron stores.	Iron	69-73	homeostatic iron regulator	Rattus norvegicus	30-33
19587290-6	2009	Here, we show that iron chelation protects, rather unexpectedly, by inhibiting the hypoxia-inducible factor prolyl 4-hydroxylase isoform 1 (PHD1), an iron and 2-oxoglutarate-dependent dioxygenase.	Iron	19-23	egl-9 family hypoxia inducible factor 2	Homo sapiens	140-144
16208485-2	2006	In the liver, HFE is required for appropriate expression of hepcidin, a humoral mediator of iron absorption.	Iron	92-96	homeostatic iron regulator	Rattus norvegicus	14-17
16208485-3	2006	HFE is also present in enterocytes, though its function in the intestine is unknown; it is not intrinsically required for iron absorption, but can augment iron absorption when over-expressed-independent of hepcidin regulation by the liver.	Iron	122-126	homeostatic iron regulator	Rattus norvegicus	0-3
16208485-3	2006	HFE is also present in enterocytes, though its function in the intestine is unknown; it is not intrinsically required for iron absorption, but can augment iron absorption when over-expressed-independent of hepcidin regulation by the liver.	Iron	155-159	homeostatic iron regulator	Rattus norvegicus	0-3
16208485-8	2006	HFE expression was increased in iron deficiency, consistent with a second regulatory role for HFE in iron absorption, independent of hepcidin from the liver.	Iron	32-36	homeostatic iron regulator	Rattus norvegicus	0-3
16208485-9	2006	DMT1 was localised primarily on the microvillus membrane, but did partially co-localise with HFE raising the possibility that the two proteins may interact to regulate iron absorption.	Iron	168-172	homeostatic iron regulator	Rattus norvegicus	93-96
16911956-1	2006	Frataxin, a highly conserved protein found in prokaryotes and eukaryotes, is required for efficient regulation of cellular iron homeostasis.	Iron	123-127	frataxin	Homo sapiens	0-8
16911956-3	2006	While frataxin"s specific function remains a point of controversy, the general consensus is that the protein assists in controlling cellular iron homeostasis by directly binding iron.	Iron	141-145	frataxin	Homo sapiens	6-14
16911956-3	2006	While frataxin"s specific function remains a point of controversy, the general consensus is that the protein assists in controlling cellular iron homeostasis by directly binding iron.	Iron	178-182	frataxin	Homo sapiens	6-14
16911956-4	2006	This review focuses on the structural and biochemical aspects of iron binding by the frataxin orthologs and outlines molecular attributes that may help explain the protein"s role in different cellular pathways.	Iron	65-69	frataxin	Homo sapiens	85-93
19587290-11	2009	Together, these studies suggest that iron chelators can prevent normoxic oxidative neuronal death through selective inhibition of PHD1 but independent of HIF-1alpha and CREB; and that HIF-2alpha, not HIF-1alpha, regulates susceptibility to normoxic oxidative neuronal death.	Iron	37-41	egl-9 family hypoxia inducible factor 2	Homo sapiens	130-134
16790430-0	2006	AtIREG2 encodes a tonoplast transport protein involved in iron-dependent nickel detoxification in Arabidopsis thaliana roots.	Iron	58-62	iron regulated 2	Arabidopsis thaliana	0-7
16469498-4	2006	We evaluate the recently recognized interaction between ferrochelatase and frataxin as a way to regulate iron delivery to ferrochelatase, and thus iron and heme metabolism.	Iron	105-109	frataxin	Homo sapiens	75-83
16469498-4	2006	We evaluate the recently recognized interaction between ferrochelatase and frataxin as a way to regulate iron delivery to ferrochelatase, and thus iron and heme metabolism.	Iron	147-151	frataxin	Homo sapiens	75-83
16790430-3	2006	In the present study we describe AtIREG2 as a nickel transporter at the vacuolar membrane that counterbalances the low substrate specificity of AtIRT1 and possibly other iron transport systems in iron-deficient root cells.	Iron	170-174	iron regulated 2	Arabidopsis thaliana	33-40
19401454-3	2009	The present study demonstrated that LDL oxidized by copper, iron, or 3-morpholinosydnonimine increased the expression of NADPH oxidase (NOX) 2, PAI-1, and heat shock factor-1 (HSF1) in human umbilical vein EC or coronary artery EC compared with LDL or vehicle.	Iron	60-64	heat shock transcription factor 1	Homo sapiens	155-174
16790430-3	2006	In the present study we describe AtIREG2 as a nickel transporter at the vacuolar membrane that counterbalances the low substrate specificity of AtIRT1 and possibly other iron transport systems in iron-deficient root cells.	Iron	196-200	iron regulated 2	Arabidopsis thaliana	33-40
16998622-1	2006	This review of the copper-iron interaction in Wilson"s disease was mainly based on ten patients (three females and seven males) studied in our institutes because the genetic tests of ATP7B for Wilson"s disease of primary copper toxicosis and HFE for hemochromatosis, the biochemical parameters of copper and iron, and morphological studies on biopsied liver specimens were complete.	Iron	26-30	homeostatic iron regulator	Homo sapiens	242-245
16870258-7	2006	Hfe and AAT are involved in iron metabolism and their polymorphisms may contribute to hepatosteatosis and altered homeostasis of lipids (role of APOE), iron, and trace minerals.	Iron	28-32	homeostatic iron regulator	Homo sapiens	0-3
16478282-3	2006	We assessed bioavailability of iron from LHb (either partially purified (LHbA) or purified (LHbD)) with and without food matrix and compared it with that from bovine hemoglobin (BHb), ferrous sulfate (FeSO4), or SRN.	Iron	31-35	lutropin subunit beta	Bos taurus	41-44
16503999-1	2006	BACKGROUND: The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis.	Iron	76-80	homeostatic iron regulator	Homo sapiens	48-51
16870258-7	2006	Hfe and AAT are involved in iron metabolism and their polymorphisms may contribute to hepatosteatosis and altered homeostasis of lipids (role of APOE), iron, and trace minerals.	Iron	152-156	homeostatic iron regulator	Homo sapiens	0-3
19401454-3	2009	The present study demonstrated that LDL oxidized by copper, iron, or 3-morpholinosydnonimine increased the expression of NADPH oxidase (NOX) 2, PAI-1, and heat shock factor-1 (HSF1) in human umbilical vein EC or coronary artery EC compared with LDL or vehicle.	Iron	60-64	heat shock transcription factor 1	Homo sapiens	176-180
19376812-2	2009	Frataxin, which is significantly reduced in patients with this recessive disorder, is a mitochondrial iron-binding protein, but how its deficiency leads to neurodegeneration and metabolic derangements is not known.	Iron	102-106	frataxin	Homo sapiens	0-8
16844841-7	2006	Among further newly implicated proteins are IRT3 and ZIP10, which have been proposed to contribute to cytoplasmic Zn influx, and FRD3 required for iron partitioning in A. thaliana.	Iron	147-151	iron regulated transporter 3	Arabidopsis thaliana	44-48
16845482-1	2006	Iron uptake in Arabidopsis thaliana is mediated by ferric chelate reductase FRO2, a transmembrane protein belonging to the flavocytochrome b family.	Iron	0-4	ferric reduction oxidase 2	Arabidopsis thaliana	76-80
16449213-1	2006	BACKGROUND: ATP-binding cassette (ABC) transporters cause various diseases and regulate many physiologic processes, such as lipid homeostasis, iron transport, and immune mechanisms.	Iron	143-147	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	12-32
16449213-1	2006	BACKGROUND: ATP-binding cassette (ABC) transporters cause various diseases and regulate many physiologic processes, such as lipid homeostasis, iron transport, and immune mechanisms.	Iron	143-147	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	34-37
19223043-11	2009	Genes relevant to RLS remain interesting candidates for ADHD; particularly BTBD9 needs further study, as it has been related to iron storage, a potential pathophysiological link between RLS and certain subtypes of ADHD.	Iron	128-132	BTB domain containing 9	Homo sapiens	75-80
16443159-5	2006	Under normal iron metabolism conditions, iron homeostasis is tightly controlled by inverse regulation of ferritin and transferrin receptor (TfR) through iron regulatory proteins (IRP).	Iron	13-17	transferrin receptor	Homo sapiens	140-143
16443159-5	2006	Under normal iron metabolism conditions, iron homeostasis is tightly controlled by inverse regulation of ferritin and transferrin receptor (TfR) through iron regulatory proteins (IRP).	Iron	41-45	transferrin receptor	Homo sapiens	118-138
16443159-5	2006	Under normal iron metabolism conditions, iron homeostasis is tightly controlled by inverse regulation of ferritin and transferrin receptor (TfR) through iron regulatory proteins (IRP).	Iron	41-45	transferrin receptor	Homo sapiens	140-143
16443159-6	2006	Increased iron levels in arsenite transformed cells should theoretically lead to higher ferritin and lower TfR in these cells than in controls.	Iron	10-14	transferrin receptor	Homo sapiens	107-110
16844240-8	2006	However, significantly elevated transcript levels of DMT1 and ferroportin1 (2.7- and 3.8-fold induction, respectively) were seen in the gastrointestinal tract, and DMT1 in the gills (1.8-fold induction) of zebrafish fed a low Fe diet.	Iron	226-228	solute carrier family 11 member 2	Danio rerio	53-57
16908409-4	2006	PAP7 in turn binds to the divalent metal transporter (DMT1), an iron import channel.	Iron	64-68	acyl-CoA binding domain containing 3	Homo sapiens	0-4
16908409-5	2006	We have identified a signaling cascade in neurons whereby stimulation of NMDA receptors activates nNOS, leading to S-nitrosylation and activation of Dexras1, which, via PAP7 and DMT1, physiologically induces iron uptake.	Iron	208-212	nitric oxide synthase 1	Homo sapiens	98-102
16908409-5	2006	We have identified a signaling cascade in neurons whereby stimulation of NMDA receptors activates nNOS, leading to S-nitrosylation and activation of Dexras1, which, via PAP7 and DMT1, physiologically induces iron uptake.	Iron	208-212	acyl-CoA binding domain containing 3	Homo sapiens	169-173
16671455-12	2006	Our results demonstrate that thrombin increases brain ceruloplasmin levels and exogenous ceruloplasmin reduces ferrous iron-induced brain edema, suggesting that ceruloplasmin up-regulation may contribute to thrombin-induced brain tolerance to ICH by limiting the injury caused by ferrous iron released from the hematoma.	Iron	119-123	ceruloplasmin	Rattus norvegicus	89-102
19568430-2	2009	In previous reports we demonstrated that PrP mediates cellular iron uptake and transport, and aggregation of PrP to the disease causing PrP-scrapie (PrP(Sc)) form results in imbalance of iron homeostasis in prion disease affected human and animal brains.	Iron	187-191	prion protein	Mus musculus	41-44
16671455-12	2006	Our results demonstrate that thrombin increases brain ceruloplasmin levels and exogenous ceruloplasmin reduces ferrous iron-induced brain edema, suggesting that ceruloplasmin up-regulation may contribute to thrombin-induced brain tolerance to ICH by limiting the injury caused by ferrous iron released from the hematoma.	Iron	119-123	ceruloplasmin	Rattus norvegicus	89-102
16908409-6	2006	As selective iron chelation prevents NMDA neurotoxicity in cortical cultures, the NMDA-NO-Dexras1-PAP7-DMT1-iron uptake signaling cascade also appears to mediate NMDA neurotoxicity.	Iron	13-17	acyl-CoA binding domain containing 3	Homo sapiens	98-102
16908409-6	2006	As selective iron chelation prevents NMDA neurotoxicity in cortical cultures, the NMDA-NO-Dexras1-PAP7-DMT1-iron uptake signaling cascade also appears to mediate NMDA neurotoxicity.	Iron	108-112	acyl-CoA binding domain containing 3	Homo sapiens	98-102
19568430-2	2009	In previous reports we demonstrated that PrP mediates cellular iron uptake and transport, and aggregation of PrP to the disease causing PrP-scrapie (PrP(Sc)) form results in imbalance of iron homeostasis in prion disease affected human and animal brains.	Iron	187-191	prion protein	Mus musculus	109-112
16877869-2	2006	Mutations in the HFE gene are associated with an increase in serum iron parameters.	Iron	67-71	homeostatic iron regulator	Homo sapiens	17-20
16877869-3	2006	The aim of this study was to estimate the heritability in serum iron parameters explained by HFE.	Iron	64-68	homeostatic iron regulator	Homo sapiens	93-96
19568430-2	2009	In previous reports we demonstrated that PrP mediates cellular iron uptake and transport, and aggregation of PrP to the disease causing PrP-scrapie (PrP(Sc)) form results in imbalance of iron homeostasis in prion disease affected human and animal brains.	Iron	187-191	prion protein	Mus musculus	109-112
16877869-9	2006	The HFE genotypes explained between 2 to 6% of the sex and age-adjusted variance in serum iron, ferritin and transferrin saturation.	Iron	90-94	homeostatic iron regulator	Homo sapiens	4-7
16760464-8	2006	This work describes a new experimental strategy to explore the IRE/IRP regulatory network and uncovers a previously unrecognized regulatory link between iron metabolism and the cell cycle.	Iron	153-157	Wnt family member 2	Homo sapiens	67-70
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	90-94	prion protein	Mus musculus	41-44
16841247-0	2006	Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells.	Iron	87-91	homeostatic iron regulator	Homo sapiens	23-26
16841247-1	2006	Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption.	Iron	78-82	homeostatic iron regulator	Homo sapiens	17-20
16841247-1	2006	Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption.	Iron	132-136	homeostatic iron regulator	Homo sapiens	17-20
16841247-2	2006	Based on the observation that ectopic expression of HFE strongly inhibits apical iron uptake (Arredondo et al., 2001, FASEB J 15, 1276-1278), a negative regulation of HFE on the apical membrane transporter DMT1 was proposed as a mechanism by which HFE regulates iron absorption.	Iron	81-85	homeostatic iron regulator	Homo sapiens	52-55
16841247-2	2006	Based on the observation that ectopic expression of HFE strongly inhibits apical iron uptake (Arredondo et al., 2001, FASEB J 15, 1276-1278), a negative regulation of HFE on the apical membrane transporter DMT1 was proposed as a mechanism by which HFE regulates iron absorption.	Iron	262-266	homeostatic iron regulator	Homo sapiens	52-55
16841247-2	2006	Based on the observation that ectopic expression of HFE strongly inhibits apical iron uptake (Arredondo et al., 2001, FASEB J 15, 1276-1278), a negative regulation of HFE on the apical membrane transporter DMT1 was proposed as a mechanism by which HFE regulates iron absorption.	Iron	262-266	homeostatic iron regulator	Homo sapiens	167-170
16877869-12	2006	The HFE genotypes explained a considerable proportion of serum iron parameters and may be an important factor in the complex iron network.	Iron	63-67	homeostatic iron regulator	Homo sapiens	4-7
16877869-12	2006	The HFE genotypes explained a considerable proportion of serum iron parameters and may be an important factor in the complex iron network.	Iron	125-129	homeostatic iron regulator	Homo sapiens	4-7
17017521-1	2006	Friedreich ataxia is due to insufficient levels of frataxin, a mitochondrial iron chaperone that shields this metal from reactive oxygen species (ROS) and renders it bioavailable as Fe II.	Iron	77-81	frataxin	Homo sapiens	51-59
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	90-94	prion protein	Mus musculus	65-68
17017521-2	2006	Frataxin participates in the synthesis of iron-sulfur clusters (ISCs), cofactors of several enzymes, including mitochondrial and cytosolic aconitase, complexes I, II and III of the respiratory chain, and ferrochelatase.	Iron	42-46	frataxin	Homo sapiens	0-8
16911529-1	2006	The discovery of iron-responsive elements (IREs), along with the identification of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of intracellular iron homeostasis.	Iron	17-21	aconitase 1	Homo sapiens	109-113
16911529-1	2006	The discovery of iron-responsive elements (IREs), along with the identification of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of intracellular iron homeostasis.	Iron	83-87	aconitase 1	Homo sapiens	109-113
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	90-94	prion protein	Mus musculus	65-68
16911529-1	2006	The discovery of iron-responsive elements (IREs), along with the identification of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of intracellular iron homeostasis.	Iron	83-87	aconitase 1	Homo sapiens	109-113
16911529-2	2006	In iron-depleted conditions, IRPs bind to IREs present in the 5"-UTR of ferritin mRNA and the 3"-UTR of transferrin receptor (TfR) mRNA.	Iron	3-7	transferrin receptor	Homo sapiens	104-124
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	168-172	prion protein	Mus musculus	41-44
16911529-2	2006	In iron-depleted conditions, IRPs bind to IREs present in the 5"-UTR of ferritin mRNA and the 3"-UTR of transferrin receptor (TfR) mRNA.	Iron	3-7	transferrin receptor	Homo sapiens	126-129
16911529-3	2006	Such binding blocks the translation of ferritin, the iron storage protein, and stabilizes TfR mRNA, whereas the opposite scenario develops when iron in the intracellular transit pool is plentiful.	Iron	53-57	transferrin receptor	Homo sapiens	90-93
16930014-3	2006	FA is caused by insufficient levels of the protein, frataxin, which is involved in mitochondrial iron metabolism.	Iron	97-101	frataxin	Homo sapiens	52-60
16911529-3	2006	Such binding blocks the translation of ferritin, the iron storage protein, and stabilizes TfR mRNA, whereas the opposite scenario develops when iron in the intracellular transit pool is plentiful.	Iron	144-148	transferrin receptor	Homo sapiens	90-93
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	168-172	prion protein	Mus musculus	65-68
16911529-4	2006	Nitrogen monoxide (commonly designated nitric oxide; NO), a gaseous molecule involved in numerous functions, is known to affect cellular iron metabolism via the IRP/IRE system.	Iron	137-141	Wnt family member 2	Homo sapiens	161-164
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	168-172	prion protein	Mus musculus	65-68
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	168-172	prion protein	Mus musculus	41-44
16875497-2	2006	The purpose of this study was to compare development of iron load in of beta2m-/- and Hfe-/- mice paying special attention to liver pathology in older age groups.	Iron	56-60	beta-2 microglobulin	Mus musculus	72-81
16570681-5	2006	We therefore looked for mutations in the HFE and other genes involved in iron metabolism in Indian patients with primary haemochromatosis.	Iron	73-77	homeostatic iron regulator	Homo sapiens	41-44
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	168-172	prion protein	Mus musculus	65-68
16875497-3	2006	Liver iron content of beta2m-/-, Hfe-/- and control B6 mice of different ages (varying from 3 weeks to 18 months) was examined.	Iron	6-10	beta-2 microglobulin	Mus musculus	22-28
16875497-5	2006	The beta2m-/- strain presents higher hepatic iron content, hepatocyte nuclear iron inclusions, mitochondria abnormalities.	Iron	45-49	beta-2 microglobulin	Mus musculus	4-10
16875497-5	2006	The beta2m-/- strain presents higher hepatic iron content, hepatocyte nuclear iron inclusions, mitochondria abnormalities.	Iron	78-82	beta-2 microglobulin	Mus musculus	4-10
16875497-8	2006	The steatosis commonly observed the beta2m-/- mice may be a reflection of its higher hepatic iron content.	Iron	93-97	beta-2 microglobulin	Mus musculus	36-42
16914832-2	2006	Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that function through post-transcriptional interactions with RNA stem loop structures called iron-responsive elements.	Iron	50-54	aconitase 1	Homo sapiens	149-153
16151844-9	2006	Iron limitation was found to enhance expression of AtOPT3.	Iron	0-4	oligopeptide transporter	Arabidopsis thaliana	51-57
19568430-3	2009	Here, we show that selective deletion of PrP in transgenic mice (PrP(KO)) alters systemic iron homeostasis as reflected in hematological parameters and levels of total iron and iron regulatory proteins in the plasma, liver, spleen, and brain of PrP(KO) mice relative to matched wild type controls.	Iron	168-172	prion protein	Mus musculus	65-68
16407072-3	2006	Conversely, under iron-replete conditions, IRP1 binds a [4Fe-4S] cluster and functions as cytosolic aconitase.	Iron	18-22	aconitase 1	Homo sapiens	43-47
16407072-4	2006	Regulation of the balance between the two IRP1 activities is complex, and it does not depend only on iron availability.	Iron	101-105	aconitase 1	Homo sapiens	42-46
16914832-2	2006	Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that function through post-transcriptional interactions with RNA stem loop structures called iron-responsive elements.	Iron	123-127	aconitase 1	Homo sapiens	149-153
16914832-2	2006	Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that function through post-transcriptional interactions with RNA stem loop structures called iron-responsive elements.	Iron	258-262	aconitase 1	Homo sapiens	149-153
19568430-4	2009	Introduction of radiolabeled iron ((59)FeCl(3)) to Wt and PrP(KO) mice by gastric gavage reveals inefficient transport of (59)Fe from the duodenum to the blood stream, an early abortive spike of erythropoiesis in the long bones and spleen, and eventual decreased (59)Fe content in red blood cells and all major organs of PrP(KO) mice relative to Wt controls.	Iron	29-33	prion protein	Mus musculus	58-61
19568430-4	2009	Introduction of radiolabeled iron ((59)FeCl(3)) to Wt and PrP(KO) mice by gastric gavage reveals inefficient transport of (59)Fe from the duodenum to the blood stream, an early abortive spike of erythropoiesis in the long bones and spleen, and eventual decreased (59)Fe content in red blood cells and all major organs of PrP(KO) mice relative to Wt controls.	Iron	29-33	prion protein	Mus musculus	321-324
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	4-8	prion protein	Mus musculus	32-35
16855468-0	2006	Association of serum iron and serum CPK in acute psychosis.	Iron	21-25	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	36-39
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	4-8	prion protein	Mus musculus	74-77
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	96-100	aconitase 1	Homo sapiens	0-32
16009382-9	2005	This results in the inhibition of a variety of iron-dependent enzymes, such as aconitase and the HIF proline hydroxylases (PHD1-3).	Iron	47-51	egl-9 family hypoxia inducible factor 2	Homo sapiens	123-127
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	4-8	prion protein	Mus musculus	74-77
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	96-100	aconitase 1	Homo sapiens	34-38
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	166-170	aconitase 1	Homo sapiens	0-32
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	4-8	prion protein	Mus musculus	74-77
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	166-170	aconitase 1	Homo sapiens	34-38
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	166-170	aconitase 1	Homo sapiens	0-32
16850017-1	2006	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to optimize cellular iron availability.	Iron	166-170	aconitase 1	Homo sapiens	34-38
16095817-5	2005	The increased H(2)O(2) toxicity in ScN 2 a cells may be related to intracellular iron status since ferrous iron (Fe(2+)) chelator 2,2"-bipyridyl (BIP) prevented H(2)O(2)-induced decrease in cell viability.	Iron	81-85	sodium channel, voltage-gated, type II, alpha	Mus musculus	35-42
16095817-5	2005	The increased H(2)O(2) toxicity in ScN 2 a cells may be related to intracellular iron status since ferrous iron (Fe(2+)) chelator 2,2"-bipyridyl (BIP) prevented H(2)O(2)-induced decrease in cell viability.	Iron	113-115	sodium channel, voltage-gated, type II, alpha	Mus musculus	35-42
16095817-6	2005	Further, the level of calcein-sensitive labile iron pool (LIP) was significantly increased in ScN 2 a cells after H(2)O(2) treatment.	Iron	47-51	sodium channel, voltage-gated, type II, alpha	Mus musculus	94-101
16850017-3	2006	IRP1 registers cytosolic iron status mainly through an iron-sulfur switch mechanism, alternating between an active cytosolic aconitase form with an iron-sulfur cluster ligated to its active site and an apoprotein form that binds IREs.	Iron	25-29	aconitase 1	Homo sapiens	0-4
16850017-3	2006	IRP1 registers cytosolic iron status mainly through an iron-sulfur switch mechanism, alternating between an active cytosolic aconitase form with an iron-sulfur cluster ligated to its active site and an apoprotein form that binds IREs.	Iron	55-59	aconitase 1	Homo sapiens	0-4
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	148-152	prion protein	Mus musculus	32-35
16850017-3	2006	IRP1 registers cytosolic iron status mainly through an iron-sulfur switch mechanism, alternating between an active cytosolic aconitase form with an iron-sulfur cluster ligated to its active site and an apoprotein form that binds IREs.	Iron	55-59	aconitase 1	Homo sapiens	0-4
16850017-5	2006	Targeted deletions of IRP1 and IRP2 in animals have demonstrated that IRP2 is the chief physiologic iron sensor.	Iron	100-104	aconitase 1	Homo sapiens	22-26
16416733-0	2005	Iron accumulation in chronic hepatitis C: relation of hepatic iron distribution, HFE genotype, and disease course.	Iron	0-4	homeostatic iron regulator	Homo sapiens	81-84
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	148-152	prion protein	Mus musculus	74-77
16858410-4	2006	Here, we report the structure of the hABH3 catalytic core in complex with iron and 2-oxoglutarate (2OG) at 1.5 A resolution and analyse key site-directed mutants.	Iron	74-78	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	37-42
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	148-152	prion protein	Mus musculus	74-77
16858410-5	2006	The hABH3 structure reveals the beta-strand jelly-roll fold that coordinates a catalytically active iron centre by a conserved His1-X-Asp/Glu-X(n)-His2 motif.	Iron	100-104	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	4-9
16416733-4	2005	The hepatic iron score increased significantly as iron accumulation involved sinusoidal and portal tract compartments and according to HFE genotypes.	Iron	12-16	homeostatic iron regulator	Homo sapiens	135-138
19568430-5	2009	The iron deficient phenotype of PrP(KO) mice is reversed by expressing Wt PrP in the PrP(KO) background, demonstrating a functional role for PrP in iron uptake and transport.	Iron	148-152	prion protein	Mus musculus	74-77
19568430-6	2009	Since iron is required for essential metabolic processes and is also potentially toxic if mismanaged, these results suggest that loss of normal function of PrP due to aggregation to the PrP(Sc) form induces imbalance of brain iron homeostasis, resulting in disease associated neurotoxicity.	Iron	6-10	prion protein	Mus musculus	156-159
16847405-10	2006	CONCLUSIONS: Iron-loading HFE mutations such as C282Y are associated with a decreased risk of PN during antiretroviral therapy.	Iron	13-17	homeostatic iron regulator	Homo sapiens	26-29
19568430-6	2009	Since iron is required for essential metabolic processes and is also potentially toxic if mismanaged, these results suggest that loss of normal function of PrP due to aggregation to the PrP(Sc) form induces imbalance of brain iron homeostasis, resulting in disease associated neurotoxicity.	Iron	6-10	prion protein	Mus musculus	186-193
15995871-12	2005	Performance of HFE mutation analysis in individuals with high iron determinations would be recommended.	Iron	62-66	homeostatic iron regulator	Homo sapiens	15-18
19385603-0	2009	Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1.	Iron	67-71	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	107-111
16679315-1	2006	In mammalian cells, iron homeostasis is largely regulated by post-transcriptional control of gene expression through the binding of iron-regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) contained in the untranslated regions of target mRNAs.	Iron	20-24	aconitase 1	Homo sapiens	158-162
16679315-1	2006	In mammalian cells, iron homeostasis is largely regulated by post-transcriptional control of gene expression through the binding of iron-regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) contained in the untranslated regions of target mRNAs.	Iron	132-136	aconitase 1	Homo sapiens	158-162
19385603-3	2009	Here, we used systematic site-directed mutagenesis and a combination of in vitro and in vivo studies to show that Nar1 holds two Fe/S clusters at conserved N- and C-terminal cysteine motifs.	Iron	129-131	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	114-118
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	129-133	hephaestin	Mus musculus	62-72
16800625-0	2006	Structural insight into poplar glutaredoxin C1 with a bridging iron-sulfur cluster at the active site.	Iron	63-67	glutaredoxin	Homo sapiens	31-43
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	129-133	hephaestin	Mus musculus	74-78
19385603-4	2009	A wealth of biochemical studies suggests that the assembly of these Fe/S clusters on Nar1 cannot be studied in Escherichia coli, as the recombinant protein does not contain the native Fe/S clusters.	Iron	68-70	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	85-89
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	162-166	hephaestin	Mus musculus	62-72
16800625-10	2006	The apo form (monomer) of Grx-C1 is a regular glutaredoxin, and the holo form (dimer) is an iron-sulfur protein with a bridging [2Fe-2S] cluster.	Iron	92-96	glutaredoxin	Homo sapiens	26-29
16800625-13	2006	When poplar Grx-C1 forms a dimer with an iron-sulfur cluster, each subunit of the holo form still retains the overall fold of the apo form.	Iron	41-45	glutaredoxin	Homo sapiens	12-15
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	162-166	hephaestin	Mus musculus	74-78
16800625-14	2006	The bridging iron-sulfur cluster in holo Grx-C1 is coordinated near the active site.	Iron	13-17	glutaredoxin	Homo sapiens	41-44
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	162-166	hephaestin	Mus musculus	62-72
16800625-18	2006	Our studies reveal that holo Grx-C1 has a novel structural and iron-sulfur cluster coordination pattern for an iron-sulfur protein.	Iron	63-67	glutaredoxin	Homo sapiens	29-32
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	162-166	hephaestin	Mus musculus	74-78
19385603-6	2009	We find that both Fe/S clusters are essential for Nar1 function and cell viability.	Iron	18-20	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	50-54
16271531-7	2005	Regulated relocalization of intestinal Cp may represent a fail-safe mechanism in which Cp shares with Heph responsibility for iron absorption under stress.	Iron	126-130	hephaestin	Mus musculus	102-106
16800625-18	2006	Our studies reveal that holo Grx-C1 has a novel structural and iron-sulfur cluster coordination pattern for an iron-sulfur protein.	Iron	111-115	glutaredoxin	Homo sapiens	29-32
17416947-3	2006	We report herein for the first time a child who had an open globe injury with a retained unusually large intraorbital foreign body (iron nut).	Iron	132-136	NUT midline carcinoma family member 1	Homo sapiens	137-140
16203876-6	2005	Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues.	Iron	52-56	sterol regulatory element binding transcription factor 1	Rattus norvegicus	152-159
19307463-6	2009	Expression for most of the iron-regulatory genes, including hepcidin, transferrin receptor 2 (TfR2), transferrin (Tf), ceruloplasmin (Cp) and iron regulatory protein 1 (IRP1), were significantly down-regulated in the tumorous tissues of these patients compared to the adjacent non-tumorous liver tissues and normal liver controls.	Iron	27-31	aconitase 1	Homo sapiens	169-173
16203876-6	2005	Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues.	Iron	52-56	fatty acid synthase	Rattus norvegicus	164-183
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
17160239-5	2006	The presence of mutation in the hemochromatosis gene (C282Y and H63D) was tested in all patients and its result was evaluated in relation to hepatic inflammatory activity, presence of fibrosis, and iron overload in the liver.	Iron	198-202	homeostatic iron regulator	Homo sapiens	32-47
16766055-6	2006	A combination of classical genetics, differential expression and genomic analysis has led to the identification of homologues of components known to operate in fungi and animals (e.g., Fox1, Ftr1, Fre1, Fer1, Ctr1/2) as well as novel molecules involved in copper and iron nutrition (Crr1, Fea1/2).	Iron	267-271	uncharacterized protein	Chlamydomonas reinhardtii	185-189
16271884-1	2005	Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process.	Iron	41-45	transferrin receptor	Homo sapiens	6-28
19455052-10	2009	In patients with anemia and CHF, correction of anemia with beta-EPO and oral iron over 1 year leads to an improvement in left and right ventricular systolic function by reducing cardiac remodeling, BNP levels, and hospitalization rate.	Iron	77-81	natriuretic peptide B	Homo sapiens	198-201
16271884-1	2005	Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process.	Iron	41-45	transferrin receptor	Homo sapiens	30-33
16271884-1	2005	Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process.	Iron	117-121	transferrin receptor	Homo sapiens	6-28
16271884-1	2005	Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process.	Iron	117-121	transferrin receptor	Homo sapiens	30-33
16271884-1	2005	Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process.	Iron	117-121	transferrin receptor	Homo sapiens	139-142
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	59-63	transferrin receptor	Homo sapiens	36-39
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
16872694-5	2006	Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system.	Iron	159-163	Wnt family member 2	Homo sapiens	117-120
16872694-5	2006	Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system.	Iron	178-182	Wnt family member 2	Homo sapiens	117-120
16520941-10	2006	Compared to the control group, the iron deficiency group also showed significantly lower values except for transferrin receptor and the ferritin levels.	Iron	35-39	transferrin receptor	Homo sapiens	107-127
16799992-10	2006	beta2-Microglobulin, which, unlike other loci, was associated with C57BL/6J alleles, is a candidate for the chromosome 2 QTL for higher iron.	Iron	136-140	beta-2 microglobulin	Mus musculus	0-19
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	77-79	transferrin receptor	Homo sapiens	36-39
19504899-5	2009	3-DAP atomic reconstruction clearly illustrate nanoscale variation of iron rich (alpha) and chromium rich (alpha") phases.	Iron	70-74	death associated protein	Homo sapiens	2-5
16241166-6	2005	One-electron oxidation of 3 leads to oxidative degradation of the fifth EtO ligand to liberate acetaldehyde even at 203 K. The iron(III)-phenoxyl radical shows high reactivity for alcoxide on iron(III) but exhibits virtually no reactivity for alcohols including even benzyl alcohol without a base to remove an alcohol proton.	Iron	127-131	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	72-75
16729984-2	2006	Previous work from this laboratory has shown that manganese (Mn) exposure alters the function of iron regulatory protein (IRP) and increases iron (Fe) concentrations in the cerebrospinal fluid (CSF).	Iron	97-101	caspase 3	Rattus norvegicus	122-125
19108947-2	2009	High concentration (more than 5mM) of AA increased cellular iron uptake by increasing transferrin receptor (TfR) expression and induced AGS cell apoptosis which was inhibited by catalase.	Iron	60-64	transferrin receptor	Homo sapiens	86-106
16777100-3	2006	The overall structure of cytochrome c(6A) follows the topology of class I c-type cytochromes in which the heme prosthetic group covalently binds to Cys16 and Cys19, and the iron has octahedral coordination with His20 and Met60 as the axial ligands.	Iron	173-177	Cytochrome c	Arabidopsis thaliana	25-37
16079130-9	2005	Difference spectroscopy revealed that catalase oxidase/substrate interactions involve the heme-iron; the resulting spectra show time-dependent decreases in the ferric heme of the enzyme with corresponding increases in the formation of an oxyferryl intermediate, potentially reflecting a compound II-like intermediate.	Iron	95-99	catalase	Bos taurus	38-46
19108947-2	2009	High concentration (more than 5mM) of AA increased cellular iron uptake by increasing transferrin receptor (TfR) expression and induced AGS cell apoptosis which was inhibited by catalase.	Iron	60-64	transferrin receptor	Homo sapiens	108-111
16230618-0	2005	The copper-iron connection in biology: structure of the metallo-oxidase Fet3p.	Iron	11-15	ferroxidase FET3	Saccharomyces cerevisiae S288C	72-77
16608849-1	2006	Frataxin is a mitochondrial protein involved in iron metabolism.	Iron	48-52	frataxin	Homo sapiens	0-8
19454351-4	2009	Here, we report that enteric infection of rhesus macaques and mice with S. Typhimurium resulted in marked Il-17- and IL-22-dependent intestinal epithelial induction and luminal accumulation of lipocalin-2, an antimicrobial protein that prevents bacterial iron acquisition.	Iron	255-259	lipocalin 2	Mus musculus	193-204
16936804-2	2006	However, it is known that iron homeostasis is regulated by divalent metal transporter 1 (DMT1; Nramp2/DCT1) in the adult small intestine.	Iron	26-30	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	59-87
16936804-2	2006	However, it is known that iron homeostasis is regulated by divalent metal transporter 1 (DMT1; Nramp2/DCT1) in the adult small intestine.	Iron	26-30	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	89-93
16230618-4	2005	The posttranslational insertion of four copper ions into Fet3p is essential for its activity, thus linking copper and iron homeostasis.	Iron	118-122	ferroxidase FET3	Saccharomyces cerevisiae S288C	57-62
16230618-8	2005	The Fet3p structure delineates features that underlie the unique reactivity of this and homologous multicopper oxidases that support the essential trafficking of iron in diverse eukaryotic organisms.	Iron	162-166	ferroxidase FET3	Saccharomyces cerevisiae S288C	4-9
16936804-2	2006	However, it is known that iron homeostasis is regulated by divalent metal transporter 1 (DMT1; Nramp2/DCT1) in the adult small intestine.	Iron	26-30	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	95-101
19416716-4	2009	The identification of FPN1B reveals how FPN1 expression can bypass IRP-dependent repression in intestinal iron uptake, even when cells throughout the body are iron deficient.	Iron	106-110	Wnt family member 2	Homo sapiens	67-70
16936804-2	2006	However, it is known that iron homeostasis is regulated by divalent metal transporter 1 (DMT1; Nramp2/DCT1) in the adult small intestine.	Iron	26-30	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	102-106
16936804-14	2006	In conclusion, our findings support the notion that until the development-dependent expression of DMT1 in the intestine is induced, mLfR may serve as an alternative iron uptake pathway.	Iron	165-169	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	98-102
16195220-8	2005	Reverse-transcription polymerase chain reaction (RT-PCR) studies revealed that the iron-containing PA coal downregulated levels of transferrin receptor (TfR) mRNA in A549 cells, which was partially restored by the addition of calcite.	Iron	83-87	transferrin receptor	Homo sapiens	131-151
16195220-8	2005	Reverse-transcription polymerase chain reaction (RT-PCR) studies revealed that the iron-containing PA coal downregulated levels of transferrin receptor (TfR) mRNA in A549 cells, which was partially restored by the addition of calcite.	Iron	83-87	transferrin receptor	Homo sapiens	153-156
30743791-2	2009	Cross-sectional and longitudinal studies have revealed that clinically significant iron-overload disease develops in at least 28% of male and 1% of female HFE C282Y homozygotes.	Iron	83-87	homeostatic iron regulator	Homo sapiens	155-158
16041808-1	2005	In a one-pot reaction of N-(5-methylthiazole-2-yl)-thiazole-2-carboxamide HL2 (3) with iron(II) acetate in air, the homotrinuclear heteroleptic mixed-valent oxo-centered iron cluster [Fe(II)Fe(III)O(L2)3(OAc)3] (4) was formed.	Iron	87-91	intelectin 2	Homo sapiens	74-77
16728543-1	2006	OBJECTIVE: The aim of this study was to describe HFE genotype in a population of patients with altered iron markers recruited in an Endocrinology Department and to define the possible phenotype-genotype relationships.	Iron	103-107	homeostatic iron regulator	Homo sapiens	49-52
16728543-7	2006	CONCLUSION: This population harboring abnormal iron markers had a different HFE genotype and a higher 282Y allele frequency than the control population.	Iron	47-51	homeostatic iron regulator	Homo sapiens	76-79
16568477-3	2006	Here we systematically evaluated the effects of in vitro manganese exposure on intracellular iron (Fe) homeostasis and iron-regulatory protein (IRP) binding activity in undifferentiated PC12 cells over a range of manganese exposure concentrations (1, 10, 50, and 200 microM MnCl(2)) and exposure durations (12, 24, 36, and 48 hr), to test the hypothesis that moderately elevated manganese exposure disrupts cellular iron regulation.	Iron	119-123	caspase 3	Rattus norvegicus	144-147
19286879-1	2009	Low levels of hepcidin are responsible for the development of iron overload in p.Cys282Tyr HFE related hemochromatosis.	Iron	62-66	homeostatic iron regulator	Homo sapiens	91-94
16642040-6	2006	TYW1 is an iron-sulfur (Fe-S) cluster protein responsible for the tricyclic formation.	Iron	24-26	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	0-4
16190762-8	2005	Experiments using ERalpha- and ERbeta-knockout mice demonstrated the expected ERalpha-subtype dependence in the tissue uptake of the known 16alpha-[18F]fluoro-17beta-estradiol ([18F]FES), which has a 6.3-fold preference for ERalpha.	Iron	182-185	estrogen receptor 2 (beta)	Mus musculus	31-37
19388095-5	2009	Plaques with significantly less iron load in the APP/PS1 animal tissues are equally conspicuous as the human plaques in the MR images.	Iron	32-36	presenilin 1	Homo sapiens	53-56
15871018-2	2005	As the other genes involved in iron metabolism have been described, non-HFE cases of HH have been identified.	Iron	31-35	homeostatic iron regulator	Homo sapiens	72-75
15986199-0	2005	Frequency and clinical expression of HFE gene mutations in a Spanish population of subjects with abnormal iron metabolism.	Iron	106-110	homeostatic iron regulator	Homo sapiens	37-40
15986199-7	2005	Very significant differences (p=0.001) in serum iron values were observed between the HFE C282Y variant homozygous and control groups.	Iron	48-52	homeostatic iron regulator	Homo sapiens	86-89
16686545-2	2006	The extrapolated affinity constants beta(1), beta(2), and beta(3)( )()for iron(III) in aqueous solution were 9.95, 18.69, and 26.02, respectively, with a corresponding pFe(3+) value of 14.64.	Iron	74-78	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	45-51
16676991-0	2006	EPR and UV-vis studies of the nitric oxide adducts of bacterial phenylalanine hydroxylase: effects of cofactor and substrate on the iron environment.	Iron	132-136	phenylalanine hydroxylase	Homo sapiens	64-89
16244452-3	2005	Iron-containing heme is required as a cofactor for nitric oxide synthase (NOS) which produces nitric oxide (NO).	Iron	0-4	nitric oxide synthase 1, neuronal	Mus musculus	51-72
19386032-2	2009	Mutations in matriptase-2 in mice and humans cause iron-deficiency anemia that responds poorly to iron therapy.	Iron	51-55	transmembrane serine protease 6	Mus musculus	13-25
19258014-2	2009	Tf binds to its receptor (TfR), which mediates iron delivery to cells through an endocytotic pathway.	Iron	47-51	transferrin receptor	Homo sapiens	26-29
16234038-3	2005	Although most adult patients with hereditary iron overload are homozygous for the C282Y mutation of the HFE gene, an increasing number with hereditary iron storage have an HFE genotype not characteristic of the disease.	Iron	45-49	homeostatic iron regulator	Homo sapiens	104-107
16234038-3	2005	Although most adult patients with hereditary iron overload are homozygous for the C282Y mutation of the HFE gene, an increasing number with hereditary iron storage have an HFE genotype not characteristic of the disease.	Iron	151-155	homeostatic iron regulator	Homo sapiens	104-107
19258014-4	2009	An atomic model of the Tf-TfR complex based on single particle electron microscopy (EM) indicated that receptor binding is indeed likely to hinder opening of the N-lobe, thus interfering with its iron release.	Iron	196-200	transferrin receptor	Homo sapiens	26-29
19258014-5	2009	The atomic model also suggested that the TfR stalks could form additional contacts with the Tf N-lobes, thus potentially further slowing down its iron release.	Iron	146-150	transferrin receptor	Homo sapiens	41-44
19204324-6	2009	These effects are mediated through down-regulation of phosphorylation of Stat3 triggered by LPS and of Smad1/5/8 induced by iron.	Iron	124-128	SMAD family member 1	Homo sapiens	103-110
16181413-0	2005	Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition.	Iron	38-42	monoamine oxidase A	Rattus norvegicus	52-69
16181413-0	2005	Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition.	Iron	38-42	monoamine oxidase A	Rattus norvegicus	203-220
16129824-0	2005	Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism.	Iron	84-88	homeostatic iron regulator	Homo sapiens	40-43
19204324-8	2009	Our findings also suggest that erythropoietic drive can inhibit both inflammatory and iron-sensing pathways, at least in part, via the suppression of STAT3 and SMAD4 signaling in vivo.	Iron	86-90	SMAD family member 4	Homo sapiens	160-165
19151392-8	2009	Exposure of ARPE-19 cells to increased iron markedly decreased phagocytosis activity, interrupted cathepsin D processing, and reduced cathepsin D activity in retinal pigment epithelial cells.	Iron	39-43	cathepsin D	Homo sapiens	98-109
16055358-9	2005	These data suggest that either the penetrance of C282Y in Russia is lower than in Western countries, or that a more frequent non-HFE dependent mechanism of primary iron overload dominates in Russian population.	Iron	164-168	homeostatic iron regulator	Homo sapiens	129-132
16183024-4	2005	The trafficking of transferrin-TfR1-PCP complex during the process of transferrin-mediated iron uptake was imaged by fluorescence resonance energy transfer between the fluorescently labeled transferrin ligand and TfR1 receptor.	Iron	91-95	transferrin receptor	Homo sapiens	31-35
16183024-4	2005	The trafficking of transferrin-TfR1-PCP complex during the process of transferrin-mediated iron uptake was imaged by fluorescence resonance energy transfer between the fluorescently labeled transferrin ligand and TfR1 receptor.	Iron	91-95	transferrin receptor	Homo sapiens	213-217
16113319-6	2005	GFP expression from these promoters was abrogated under low-iron conditions in the presence of both IdeR(D177K) and DtxR(E175K), a result confirmed by reverse transcription-PCR.	Iron	60-64	MarR family transcriptional regulator	Corynebacterium diphtheriae	116-120
16117536-3	2005	The peroxo unit is bound end-on to the copper, and side-on to the high-spin iron, for an overall mu-eta(1):eta(2) coordination mode.	Iron	76-80	DNA polymerase iota	Homo sapiens	107-113
16117536-8	2005	The pi*(sigma) interaction with both the half-occupied d(z)2 orbital on the copper (eta(1)) and the d(xz) orbital on the iron (eta(2)), provides an effective superexchange pathway for strong antiferromagnetic coupling between the metal centers.	Iron	121-125	DNA polymerase iota	Homo sapiens	127-133
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	wingless-type MMTV integration site family, member 2	Mus musculus	120-143
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	wingless-type MMTV integration site family, member 2	Mus musculus	145-148
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	186-214
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	216-221
15744772-4	2005	In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels.	Iron	55-59	transferrin receptor	Mus musculus	114-134
15744772-4	2005	In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels.	Iron	55-59	transferrin receptor	Mus musculus	136-139
15744772-8	2005	This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption.	Iron	43-47	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	203-208
15744772-8	2005	This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption.	Iron	216-220	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	203-208
15883202-5	2005	Doxorubicin can directly bind iron and can perturb iron metabolism by interacting with multiple molecular targets, including the iron regulatory proteins (IRP) 1 and 2.	Iron	30-34	aconitase 1	Homo sapiens	129-167
15883202-5	2005	Doxorubicin can directly bind iron and can perturb iron metabolism by interacting with multiple molecular targets, including the iron regulatory proteins (IRP) 1 and 2.	Iron	51-55	aconitase 1	Homo sapiens	129-167
16132699-3	2005	In addition, sod 1 Delta and sod 1 Deltasod 2 Delta had higher iron levels than the wild-type, independently of H(2)O(2) stress.	Iron	63-67	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	13-18
16132699-3	2005	In addition, sod 1 Delta and sod 1 Deltasod 2 Delta had higher iron levels than the wild-type, independently of H(2)O(2) stress.	Iron	63-67	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	29-34
16012706-0	2005	Do cancer cells selectively mutate HFE to increase their intracellular iron?	Iron	71-75	homeostatic iron regulator	Homo sapiens	35-38
16012706-2	2005	Transferrin receptor (TfR), an essential transport protein that enables cells to satisfy their need of iron, is upregulated in cancer cells.	Iron	103-107	transferrin receptor	Homo sapiens	0-20
16012706-2	2005	Transferrin receptor (TfR), an essential transport protein that enables cells to satisfy their need of iron, is upregulated in cancer cells.	Iron	103-107	transferrin receptor	Homo sapiens	22-25
16012706-3	2005	The hemochromatosis gene (HFE) produces a protein that interacts with TfR; and we hypothesized that tumor cells would selectively mutate HFE to improve their iron-uptake and thus provide themselves a growth advantage over non-tumor cells.	Iron	158-162	homeostatic iron regulator	Homo sapiens	26-29
16012706-3	2005	The hemochromatosis gene (HFE) produces a protein that interacts with TfR; and we hypothesized that tumor cells would selectively mutate HFE to improve their iron-uptake and thus provide themselves a growth advantage over non-tumor cells.	Iron	158-162	transferrin receptor	Homo sapiens	70-73
16012706-3	2005	The hemochromatosis gene (HFE) produces a protein that interacts with TfR; and we hypothesized that tumor cells would selectively mutate HFE to improve their iron-uptake and thus provide themselves a growth advantage over non-tumor cells.	Iron	158-162	homeostatic iron regulator	Homo sapiens	137-140
16248429-6	2005	ETF-QO is an iron sulfur protein located in mitochondria inner membrane containing two kinds of redox center: FAD and [4Fe-4S] center.	Iron	13-17	electron transfer flavoprotein dehydrogenase	Rattus norvegicus	0-6
16248429-9	2005	Results demonstrated that the 32 amino acid peptide was a mitochondrial targeting peptide, and both FAD and iron-sulfur cluster were inserted properly into the expressed ETF-QO.	Iron	108-112	electron transfer flavoprotein dehydrogenase	Rattus norvegicus	170-176
16212169-0	2005	[Study on dechlorination of p-chlorophenol by Ni/Fe bimetallic particles].	Iron	49-51	p-chlorophenol	None	28-42
15989963-2	2005	We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed in iron-replete conditions in the absence of the S. cerevisiae RNase III ortholog Rnt1p or of the nuclear exosome component Rrp6p.	Iron	33-37	exosome nuclease subunit RRP6	Saccharomyces cerevisiae S288C	213-218
15989963-2	2005	We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed in iron-replete conditions in the absence of the S. cerevisiae RNase III ortholog Rnt1p or of the nuclear exosome component Rrp6p.	Iron	48-52	exosome nuclease subunit RRP6	Saccharomyces cerevisiae S288C	213-218
15989963-2	2005	We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed in iron-replete conditions in the absence of the S. cerevisiae RNase III ortholog Rnt1p or of the nuclear exosome component Rrp6p.	Iron	48-52	exosome nuclease subunit RRP6	Saccharomyces cerevisiae S288C	213-218
15989963-4	2005	RNase III-deficient cells are hypersensitive to high iron concentrations, suggesting that Rnt1p-mediated RNA surveillance is required to prevent iron toxicity.	Iron	53-57	ribonuclease III	Saccharomyces cerevisiae S288C	90-95
15989963-4	2005	RNase III-deficient cells are hypersensitive to high iron concentrations, suggesting that Rnt1p-mediated RNA surveillance is required to prevent iron toxicity.	Iron	145-149	ribonuclease III	Saccharomyces cerevisiae S288C	90-95
15990686-2	2005	The C282Y and H63D mutations in the hemochromatosis (HFE) gene are associated with increased serum iron levels and net iron accumulation.	Iron	99-103	homeostatic iron regulator	Homo sapiens	53-56
15990686-2	2005	The C282Y and H63D mutations in the hemochromatosis (HFE) gene are associated with increased serum iron levels and net iron accumulation.	Iron	119-123	homeostatic iron regulator	Homo sapiens	53-56
15956653-7	2005	RESULTS: Women with any HFE gene mutation had higher total body iron stores, as reflected by higher transferrin saturations (P &lt; .001) and lower levels of the ratio of transferrin receptors to ferritin (P = .02), than women with no HFE gene mutation.	Iron	64-68	homeostatic iron regulator	Homo sapiens	24-27
15974953-4	2005	In humans, this could explain that low levels of hepcidin found during juvenile haemochromatosis and HFE-1 genetic haemochromatosis are associated with an iron overload phenotype.	Iron	155-159	homeostatic iron regulator	Homo sapiens	101-106
15845361-4	2005	Using microarray assays, we discovered that SSAT was enhanced under both oxygen- and iron-deficient conditions.	Iron	85-89	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	44-48
15845371-1	2005	Aryl hydrocarbon receptor ligands, such as polychlorinated biphenyls (PCBs), cause inhibition of the heme biosynthesis enzyme, uroporphyrinogen decarboxylase; this leads to uroporphyria and hepatic tumors, which are markedly enhanced by iron overload in C57BL/10 and C57BL/6 strains of mice.	Iron	237-241	uroporphyrinogen decarboxylase	Mus musculus	127-157
16511074-1	2005	Iron-regulatory proteins (IRPs) 1 and 2 are closely related molecules involved in animal iron metabolism.	Iron	89-93	aconitase 1	Homo sapiens	0-39
16511074-3	2005	In iron-replete cells, IRP1, but not IRP2, binds a [4Fe-4S] cluster and functions as a cytoplasmic aconitase, with simultaneous loss of its RNA-binding ability.	Iron	3-7	aconitase 1	Homo sapiens	23-27
16511074-4	2005	Whereas IRP2 is known to be involved in Fe homeostasis, the role of IRP1 is less clear; it may provide a link between citrate and iron metabolisms and be involved in oxidative stress response.	Iron	130-134	aconitase 1	Homo sapiens	68-72
15837926-3	2005	Here we present the 3.5-A crystal structure of the PSMA ectodomain, which reveals a homodimer with structural similarity to transferrin receptor, a receptor for iron-loaded transferrin that lacks protease activity.	Iron	161-165	transferrin receptor	Homo sapiens	124-156
15840721-10	2005	Aconitase was found to associate with the iron binding protein frataxin exclusively during reperfusion.	Iron	42-46	frataxin	Homo sapiens	63-71
16053912-0	2005	Case report of a patient with non-alcoholic fatty liver disease, moderate iron overload who is homozygous for the S65C mutation in the HFE1 gene.	Iron	74-78	homeostatic iron regulator	Homo sapiens	135-139
15750326-5	2005	The known proteins of iron transport and storage, transferrin, transferrin receptor and ferritin, have been recently linked with a number of newly identified proteins that are responsible for inherited diseases of iron metabolisms and play critical roles in the maintenance of iron homeostasis.	Iron	22-26	transferrin receptor	Homo sapiens	63-83
15750326-5	2005	The known proteins of iron transport and storage, transferrin, transferrin receptor and ferritin, have been recently linked with a number of newly identified proteins that are responsible for inherited diseases of iron metabolisms and play critical roles in the maintenance of iron homeostasis.	Iron	214-218	transferrin receptor	Homo sapiens	63-83
15777842-3	2005	Enzymes of this class, such as prolyl-4-hydroxylases, mediate the oxygen and iron-dependent degradation of the hypoxia inducible factor HIF-1alpha, which requires the E3 ubiquitin ligase activity of pVHL.	Iron	77-81	von Hippel-Lindau tumor suppressor	Homo sapiens	199-203
15777851-1	2005	Through the insertion of an iron responsive element (IRE) into a pd2ECFP vector, we demonstrate a noninvasive method for determining alterations in iron regulatory protein (IRP) activity that results in changes in protein translation in living cells.	Iron	28-32	Wnt family member 2	Homo sapiens	173-176
15649888-8	2005	The iron regulon is induced in cells depleted of Atm1 with Aft1 largely responsible for the induced gene expression.	Iron	4-8	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	49-53
15649888-12	2005	Thus, iron sensing by Aft1/Aft2 is not linked to the maturation of cytosolic/nuclear Fe-S proteins, but the mitochondrial inner membrane transporter Atm1 is important to transport the inhibitory signal.	Iron	6-10	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	149-153
15528318-7	2005	Earlier studies found that in HeLa cells, HFE expression lowers Tf-mediated iron uptake; here we show that HFE lowers non-Tf-bound iron in TRVb cells and add to a growing body of evidence that HFE may play different roles in different cell types.	Iron	76-80	homeostatic iron regulator	Homo sapiens	42-45
15528318-7	2005	Earlier studies found that in HeLa cells, HFE expression lowers Tf-mediated iron uptake; here we show that HFE lowers non-Tf-bound iron in TRVb cells and add to a growing body of evidence that HFE may play different roles in different cell types.	Iron	131-135	homeostatic iron regulator	Homo sapiens	107-110
16644885-6	2006	CONCLUSIONS: The study shows that from a population of patients in whom a routine liver function profile had been requested, it is possible to detect subjects homozygous for the C282Y HFE genotype who have clinical or biochemical markers of iron overload.	Iron	241-245	homeostatic iron regulator	Homo sapiens	184-187
16728372-2	2006	Iron response protein (IRP) binding activity is a useful indirect measurement of changes in Fe status, as reductions in cell Fe levels lead to increases in IRP binding.	Iron	0-4	caspase 3	Rattus norvegicus	23-26
16728372-2	2006	Iron response protein (IRP) binding activity is a useful indirect measurement of changes in Fe status, as reductions in cell Fe levels lead to increases in IRP binding.	Iron	0-4	caspase 3	Rattus norvegicus	156-159
16728372-2	2006	Iron response protein (IRP) binding activity is a useful indirect measurement of changes in Fe status, as reductions in cell Fe levels lead to increases in IRP binding.	Iron	92-94	caspase 3	Rattus norvegicus	23-26
16728372-2	2006	Iron response protein (IRP) binding activity is a useful indirect measurement of changes in Fe status, as reductions in cell Fe levels lead to increases in IRP binding.	Iron	92-94	caspase 3	Rattus norvegicus	156-159
16728372-2	2006	Iron response protein (IRP) binding activity is a useful indirect measurement of changes in Fe status, as reductions in cell Fe levels lead to increases in IRP binding.	Iron	125-127	caspase 3	Rattus norvegicus	23-26
16728372-2	2006	Iron response protein (IRP) binding activity is a useful indirect measurement of changes in Fe status, as reductions in cell Fe levels lead to increases in IRP binding.	Iron	125-127	caspase 3	Rattus norvegicus	156-159
16325423-1	2006	Cysteine dioxygenase (CDO, EC 1.13.11.20) is a non-heme mononuclear iron enzyme that oxidizes cysteine to cysteinesulfinate.	Iron	68-72	cysteine dioxygenase type 1	Rattus norvegicus	22-25
16698547-2	2006	Its transcript is a small acidic protein that binds the desulfurase IscS, which is essential in iron-specific metabolic pathways.	Iron	96-100	NFS1 cysteine desulfurase	Homo sapiens	68-72
16698547-5	2006	The IscS interaction surface is the same as that involved in iron binding.	Iron	61-65	NFS1 cysteine desulfurase	Homo sapiens	4-8
16698547-6	2006	This observation and the pattern of conservation through species strongly suggest that YfhJ is a molecular adaptor that is able to modulate the function of IscS in iron-sulfur cluster formation.	Iron	164-168	NFS1 cysteine desulfurase	Homo sapiens	156-160
15726136-1	2005	A range of 1,3-aryl linked, bis-beta-diketone derivatives (LH2) has been employed to synthesise neutral bis(ligand), dinuclear complexes incorporating square-planar copper(II) and tris(ligand) dinuclear helical derivatives containing octahedral iron(III).	Iron	245-249	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	59-62
16571656-7	2006	However, the viability of iron-deficient flies is compromised by overexpression of mitochondrial ferritin, suggesting that it may sequester iron at the expense of other important cellular functions.	Iron	26-30	Ferritin 1 heavy chain homologue	Drosophila melanogaster	97-105
19151392-8	2009	Exposure of ARPE-19 cells to increased iron markedly decreased phagocytosis activity, interrupted cathepsin D processing, and reduced cathepsin D activity in retinal pigment epithelial cells.	Iron	39-43	cathepsin D	Homo sapiens	134-145
16571656-7	2006	However, the viability of iron-deficient flies is compromised by overexpression of mitochondrial ferritin, suggesting that it may sequester iron at the expense of other important cellular functions.	Iron	140-144	Ferritin 1 heavy chain homologue	Drosophila melanogaster	97-105
16571656-8	2006	The conservation of mitochondrial ferritin in an insect species underscores the importance of this iron-storage molecule.	Iron	99-103	Ferritin 1 heavy chain homologue	Drosophila melanogaster	34-42
19211831-3	2009	We delineated the role of murine Slc11a2 [divalent metal ion transporter-1 (DMT-1)] in hippocampal neuronal iron uptake during development and memory formation.	Iron	108-112	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	42-74
15725899-4	2005	Insights into the regulation of hepcidin antimicrobial peptide expression by known iron metabolic proteins such as HFE, hemojuvelin, and transferrin receptor 2 are expanding the understanding of the genetic circuitry that controls iron absorption and utilization.	Iron	83-87	homeostatic iron regulator	Homo sapiens	115-118
19211831-3	2009	We delineated the role of murine Slc11a2 [divalent metal ion transporter-1 (DMT-1)] in hippocampal neuronal iron uptake during development and memory formation.	Iron	108-112	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	76-81
19211831-5	2009	Slc11a2(hipp/hipp) mice had lower hippocampal iron content; altered developmental expression of genes involved in iron homeostasis, energy metabolism, and dendrite morphogenesis; reductions in markers for energy metabolism and glutamatergic neurotransmission on magnetic resonance spectroscopy; and altered pyramidal neuron dendrite morphology in area 1 of Ammon"s Horn in the hippocampus.	Iron	46-50	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-7
15775751-1	2005	The hereditary hemochromatosis (HHC) gene, HFE on chromosome 6p21.3, encodes a protein involved in iron homeostasis.	Iron	99-103	homeostatic iron regulator	Homo sapiens	43-46
15775751-2	2005	HFE mutations have low penetrance with a mild effect on serum iron levels.	Iron	62-66	homeostatic iron regulator	Homo sapiens	0-3
15775751-7	2005	Case-control studies have reported associations between HFE mutations C282Y/H63D and several cancers, some of which in interaction with the transferrin receptor gene TFRC or dietary iron intake.	Iron	182-186	homeostatic iron regulator	Homo sapiens	56-59
16537971-3	2006	The majority of clinical cases of iron overload is caused by mutations in the HFE gene.	Iron	34-38	homeostatic iron regulator	Homo sapiens	78-81
16537971-4	2006	However, the role that HFE plays in the physiology of intestinal iron absorption remains enigmatic.	Iron	65-69	homeostatic iron regulator	Homo sapiens	23-26
15775751-13	2005	Given the population frequency of C282Y and the connection between iron and cancer, clarification of the mechanism of HFE associations in leukemia and cancer will have strong implications in public health.	Iron	67-71	homeostatic iron regulator	Homo sapiens	118-121
16537971-5	2006	Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes.	Iron	66-70	homeostatic iron regulator	Homo sapiens	40-43
19211831-5	2009	Slc11a2(hipp/hipp) mice had lower hippocampal iron content; altered developmental expression of genes involved in iron homeostasis, energy metabolism, and dendrite morphogenesis; reductions in markers for energy metabolism and glutamatergic neurotransmission on magnetic resonance spectroscopy; and altered pyramidal neuron dendrite morphology in area 1 of Ammon"s Horn in the hippocampus.	Iron	114-118	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-7
16537971-5	2006	Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes.	Iron	193-197	homeostatic iron regulator	Homo sapiens	144-147
16537971-5	2006	Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes.	Iron	193-197	homeostatic iron regulator	Homo sapiens	144-147
19211831-8	2009	Slc11a2(WT/WT) mice had upregulation of genes involved in iron uptake and metabolism in response to MWM training, and Slc11a2(hipp/hipp) mice had differential expression of these genes compared with Slc11a2(WT/WT) mice.	Iron	58-62	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-7
16537971-8	2006	These models are not mutually exclusive, and it is possible that HFE influences the iron status in each of these cell populations, leading to cell type-specific downstream effects on intestinal iron absorption and body iron distribution.	Iron	84-88	homeostatic iron regulator	Homo sapiens	65-68
16537971-8	2006	These models are not mutually exclusive, and it is possible that HFE influences the iron status in each of these cell populations, leading to cell type-specific downstream effects on intestinal iron absorption and body iron distribution.	Iron	194-198	homeostatic iron regulator	Homo sapiens	65-68
15805002-4	2005	The patient referred by us confirm the possibility of precocious alteration of iron indices in patients with heterozygosity for beta-thalassemia inherited together with HFE mutations.	Iron	79-83	homeostatic iron regulator	Homo sapiens	169-172
16537971-8	2006	These models are not mutually exclusive, and it is possible that HFE influences the iron status in each of these cell populations, leading to cell type-specific downstream effects on intestinal iron absorption and body iron distribution.	Iron	194-198	homeostatic iron regulator	Homo sapiens	65-68
19211831-9	2009	Neuronal iron uptake by DMT-1 is essential for normal hippocampal neuronal development and Slc11a2 expression is induced by spatial memory training.	Iron	9-13	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	24-29
19211831-9	2009	Neuronal iron uptake by DMT-1 is essential for normal hippocampal neuronal development and Slc11a2 expression is induced by spatial memory training.	Iron	9-13	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	91-98
19347027-6	2009	FXN mutations cause deficiencies of the iron-sulfur cluster-containing subunits of the mitochondrial electron transport complexes I, II, and III, and of the iron-sulfur protein aconitase.	Iron	40-44	frataxin	Homo sapiens	0-3
16551544-3	2006	Analysis of genes encoding new members of the Tsf family and non-secreted ferritin subunits allows making preliminary hypotheses about their possible functions and opens possibilities to study lesser-known aspects of insect iron homeostasis.	Iron	224-228	Ferritin 1 heavy chain homologue	Drosophila melanogaster	74-82
16552061-10	2006	The hlyB and hlyA genes are organized in an operon that is coordinately regulated by iron and oxygen.	Iron	85-89	hemolysin transport protein	Escherichia coli	13-17
15695640-0	2005	Iron-mediated control of the basic helix-loop-helix protein FER, a regulator of iron uptake in tomato.	Iron	0-4	bHLH transcriptional regulator	Solanum lycopersicum	60-63
15695640-0	2005	Iron-mediated control of the basic helix-loop-helix protein FER, a regulator of iron uptake in tomato.	Iron	80-84	bHLH transcriptional regulator	Solanum lycopersicum	60-63
15695640-2	2005	The FER gene, encoding a basic helix-loop-helix domain protein and putative transcription factor, is required for induction of iron mobilization genes in roots of tomato (Lycopersicon esculentum).	Iron	127-131	bHLH transcriptional regulator	Solanum lycopersicum	4-7
15695640-3	2005	To study upstream regulatory events of FER action, we examined the control of FER gene and FER protein expression in response to iron nutritional status.	Iron	129-133	bHLH transcriptional regulator	Solanum lycopersicum	39-42
15695640-3	2005	To study upstream regulatory events of FER action, we examined the control of FER gene and FER protein expression in response to iron nutritional status.	Iron	129-133	bHLH transcriptional regulator	Solanum lycopersicum	78-81
15695640-3	2005	To study upstream regulatory events of FER action, we examined the control of FER gene and FER protein expression in response to iron nutritional status.	Iron	129-133	bHLH transcriptional regulator	Solanum lycopersicum	78-81
15695640-6	2005	We found that the FER gene and FER protein were consistently down-regulated in roots after generous (100 mum, physiologically optimal) iron supply compared to low (0.1 mum) and sufficient (10 mum) iron supply.	Iron	135-139	bHLH transcriptional regulator	Solanum lycopersicum	18-21
16552061-13	2006	In contrast, the hlyA gene was also expressed as a single mRNA in iron-rich medium, but its expression was reduced approximately threefold under low-iron conditions in a Fur-independent manner.	Iron	66-70	hemolysin transport protein	Escherichia coli	17-21
16552061-13	2006	In contrast, the hlyA gene was also expressed as a single mRNA in iron-rich medium, but its expression was reduced approximately threefold under low-iron conditions in a Fur-independent manner.	Iron	149-153	hemolysin transport protein	Escherichia coli	17-21
16552061-14	2006	This suggests that hlyA alone is regulated by an unidentified iron-dependent regulator.	Iron	62-66	hemolysin transport protein	Escherichia coli	19-23
16552061-16	2006	Taken together, these results suggest that iron and oxidative stress have an effect on the control of hlyBA and hlyA transcriptional levels.	Iron	43-47	hemolysin transport protein	Escherichia coli	112-116
15695640-6	2005	We found that the FER gene and FER protein were consistently down-regulated in roots after generous (100 mum, physiologically optimal) iron supply compared to low (0.1 mum) and sufficient (10 mum) iron supply.	Iron	135-139	bHLH transcriptional regulator	Solanum lycopersicum	31-34
15695640-6	2005	We found that the FER gene and FER protein were consistently down-regulated in roots after generous (100 mum, physiologically optimal) iron supply compared to low (0.1 mum) and sufficient (10 mum) iron supply.	Iron	197-201	bHLH transcriptional regulator	Solanum lycopersicum	18-21
15695640-6	2005	We found that the FER gene and FER protein were consistently down-regulated in roots after generous (100 mum, physiologically optimal) iron supply compared to low (0.1 mum) and sufficient (10 mum) iron supply.	Iron	197-201	bHLH transcriptional regulator	Solanum lycopersicum	31-34
15695640-7	2005	FER gene and FER protein expression were also occasionally down-regulated at sufficient compared to low iron supply.	Iron	104-108	bHLH transcriptional regulator	Solanum lycopersicum	0-3
15695640-7	2005	FER gene and FER protein expression were also occasionally down-regulated at sufficient compared to low iron supply.	Iron	104-108	bHLH transcriptional regulator	Solanum lycopersicum	13-16
15695640-8	2005	Analysis of FER protein expression in FER overexpression plants, as well as cellular protein localization studies, indicated that FER was down-regulated by high iron at the posttranscriptional level.	Iron	161-165	bHLH transcriptional regulator	Solanum lycopersicum	12-15
16373528-9	2006	Furthermore, because HFE regulates iron and gallium uptake, the two Tf-TfR1-HFE complexes in R cells may be involved in reduced (67)Ga and (59)Fe uptake compared with S cells.	Iron	35-39	homeostatic iron regulator	Homo sapiens	21-24
15695640-8	2005	Analysis of FER protein expression in FER overexpression plants, as well as cellular protein localization studies, indicated that FER was down-regulated by high iron at the posttranscriptional level.	Iron	161-165	bHLH transcriptional regulator	Solanum lycopersicum	38-41
19047682-3	2009	We hypothesized that transferrin plays a critical role both in iron transport and in regulating hepcidin expression in zebrafish embryos.	Iron	63-67	transferrin-a	Danio rerio	21-32
15695640-8	2005	Analysis of FER protein expression in FER overexpression plants, as well as cellular protein localization studies, indicated that FER was down-regulated by high iron at the posttranscriptional level.	Iron	161-165	bHLH transcriptional regulator	Solanum lycopersicum	38-41
15695640-10	2005	FER protein regulation in the iron accumulation mutant chloronerva indicated that FER protein expression was not directly controlled by signals derived from iron transport.	Iron	30-34	bHLH transcriptional regulator	Solanum lycopersicum	0-3
15695640-10	2005	FER protein regulation in the iron accumulation mutant chloronerva indicated that FER protein expression was not directly controlled by signals derived from iron transport.	Iron	30-34	bHLH transcriptional regulator	Solanum lycopersicum	82-85
15695640-11	2005	We conclude that FER is able to affect transcription in the nucleus and its action is controlled by iron supply at multiple regulatory levels.	Iron	100-104	bHLH transcriptional regulator	Solanum lycopersicum	17-20
16373528-9	2006	Furthermore, because HFE regulates iron and gallium uptake, the two Tf-TfR1-HFE complexes in R cells may be involved in reduced (67)Ga and (59)Fe uptake compared with S cells.	Iron	35-39	transferrin receptor	Homo sapiens	71-75
16373528-9	2006	Furthermore, because HFE regulates iron and gallium uptake, the two Tf-TfR1-HFE complexes in R cells may be involved in reduced (67)Ga and (59)Fe uptake compared with S cells.	Iron	35-39	homeostatic iron regulator	Homo sapiens	76-79
16373528-9	2006	Furthermore, because HFE regulates iron and gallium uptake, the two Tf-TfR1-HFE complexes in R cells may be involved in reduced (67)Ga and (59)Fe uptake compared with S cells.	Iron	143-145	transferrin receptor	Homo sapiens	71-75
16373528-9	2006	Furthermore, because HFE regulates iron and gallium uptake, the two Tf-TfR1-HFE complexes in R cells may be involved in reduced (67)Ga and (59)Fe uptake compared with S cells.	Iron	143-145	homeostatic iron regulator	Homo sapiens	76-79
19047682-5	2009	Morpholino knockdown of transferrin-a in wild-type embryos reproduced the anemia phenotype and decreased somite and terminal gut iron staining, while coinjection of transferrin-a cRNA partially restored these defects.	Iron	129-133	transferrin-a	Danio rerio	24-35
16322095-2	2006	However, it appears that Sertoli cell function is regulated by adjacent spermatogonial cells in the testis because expression of lipocalin-2 mRNA, which encodes an iron-siderophore-binding protein, is barely detectable in Sertoli cells of germ cell-deficient W/Wv mice, and more abundantly expressed in jsd/jsd mice.	Iron	164-168	lipocalin 2	Mus musculus	129-140
15752985-1	2005	Iron-sulfur (Fe-S) clusters (ISCs) are versatile, ancient co-factors of proteins that are involved in electron transport, enzyme catalysis and regulation of gene expression.	Iron	13-17	NFS1 cysteine desulfurase	Homo sapiens	29-33
19047682-7	2009	These data indicate that transferrin-a transports iron and that hepcidin expression is regulated by a transferrin-a-dependent pathway in the zebrafish embryo.	Iron	50-54	transferrin-a	Danio rerio	25-36
19103311-5	2009	At pH 5.6, the TFR considerably enhances iron release from the C-lobe (with little effect on iron release from the N-lobe).	Iron	41-45	transferrin receptor	Homo sapiens	15-18
15615730-2	2005	Studies with both yeast and mammals have suggested that decreased frataxin levels lead to elevated intramitochondrial concentrations of labile (chelatable) iron, and consequently to oxidative mitochondrial damage.	Iron	156-160	frataxin	Homo sapiens	66-74
16621727-11	2006	These combined data show that the POS5 NAD/H kinase is an important protein required for a variety of essential cellular pathways and that deficient iron-sulfur cluster assembly may play a critical role in the mitochondrial mutator phenotype observed in the pos5Delta.	Iron	149-153	NADH kinase	Saccharomyces cerevisiae S288C	34-38
19103311-7	2009	In the hTF/TFR complex these residues could contribute to and compromise the readout ascribed to iron release from hTF.	Iron	97-101	transferrin receptor	Homo sapiens	11-14
15615771-1	2005	Friedreich ataxia (FRDA) results from a generalized deficiency of mitochondrial and cytosolic iron-sulfur protein activity initially ascribed to mitochondrial iron overload.	Iron	94-98	frataxin	Homo sapiens	0-17
16599945-5	2006	The intense immunolabelling of ferritin and Mn SOD most likely reflects a defensive response to iron-mediated oxidative stress.	Iron	96-100	superoxide dismutase 2	Homo sapiens	44-50
19258483-1	2009	Iron metabolism has been implicated in carcinogenesis and several studies assessed the potential role of genetic variants of proteins involved in iron metabolism (HFE C282Y, TFR S142G) in different malignancies.	Iron	146-150	homeostatic iron regulator	Homo sapiens	163-166
16601269-1	2006	The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO).	Iron	262-266	heme oxygenase 2	Homo sapiens	81-85
16467350-2	2006	The mitochondrial ABC half-transporter Abcb7, which is mutated in X-linked sideroblastic anemia with ataxia in humans, is a functional ortholog of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosolic Fe-S cluster assembly.	Iron	246-250	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	18-21
16467350-2	2006	The mitochondrial ABC half-transporter Abcb7, which is mutated in X-linked sideroblastic anemia with ataxia in humans, is a functional ortholog of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosolic Fe-S cluster assembly.	Iron	246-250	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	153-158
16467350-6	2006	A notable exception to this was liver, where loss of Abcb7 impaired cytosolic Fe-S cluster assembly but was not lethal.	Iron	78-82	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	53-58
15615771-1	2005	Friedreich ataxia (FRDA) results from a generalized deficiency of mitochondrial and cytosolic iron-sulfur protein activity initially ascribed to mitochondrial iron overload.	Iron	94-98	frataxin	Homo sapiens	19-23
15615771-2	2005	Recent in vitro data suggest that frataxin is necessary for iron incorporation in Fe-S cluster (ISC) and heme biosynthesis.	Iron	60-64	frataxin	Homo sapiens	34-42
15615771-2	2005	Recent in vitro data suggest that frataxin is necessary for iron incorporation in Fe-S cluster (ISC) and heme biosynthesis.	Iron	82-86	frataxin	Homo sapiens	34-42
15694310-7	2005	Our data indicate that the spacer domain of PAR-1 is required for lateral PM localization of PAR-1 kinase and for development of a polarized FE.	Iron	141-143	par-1	Drosophila melanogaster	44-49
16467350-8	2006	Altogether, these studies demonstrate the essential nature of Abcb7 in mammals and further substantiate a central role for mitochondria in the biogenesis of cytosolic Fe-S proteins.	Iron	167-171	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	62-67
19258483-1	2009	Iron metabolism has been implicated in carcinogenesis and several studies assessed the potential role of genetic variants of proteins involved in iron metabolism (HFE C282Y, TFR S142G) in different malignancies.	Iron	146-150	transferrin receptor	Homo sapiens	174-177
16412980-6	2006	The level of MRCKalpha mRNA in various tissues strongly positively correlates with the level of TfR mRNA, indicating its possible role in the transferrin iron uptake pathway.	Iron	154-158	transferrin receptor	Homo sapiens	96-99
19254564-0	2009	Iron sensing as a partnership: HFE and transferrin receptor 2.	Iron	0-4	homeostatic iron regulator	Homo sapiens	31-34
16511314-2	2006	Interconversion of IRP1 between these mutually exclusive states is central to cellular iron regulation and is accomplished through iron-responsive assembly and disassembly of a [4Fe-4S] cluster.	Iron	87-91	aconitase 1	Homo sapiens	19-23
16511314-2	2006	Interconversion of IRP1 between these mutually exclusive states is central to cellular iron regulation and is accomplished through iron-responsive assembly and disassembly of a [4Fe-4S] cluster.	Iron	131-135	aconitase 1	Homo sapiens	19-23
16511314-3	2006	When in its apo form, IRP1 binds to iron responsive elements (IREs) found in mRNAs encoding proteins of iron storage and transport and either prevents translation or degradation of the bound mRNA.	Iron	36-40	aconitase 1	Homo sapiens	22-26
15631519-3	2005	Iron-loaded Caco-2 cells, with reduced DMT-1 and elevated HFE mRNA levels, down-regulated uptake from ferrous ascorbate and bisglycinate but not from ferric compounds.	Iron	0-4	homeostatic iron regulator	Homo sapiens	58-61
19254564-1	2009	The mechanism by which HFE participates in the regulation of iron homeostasis has remained enigmatic.	Iron	61-65	homeostatic iron regulator	Homo sapiens	23-26
15934200-2	2005	Following irradiation of human fibroblast cells with 600 MeV/nucleon silicon and 600 MeV/nucleon iron ions we observed the formation of gamma-H2AX aggregates in the shape of streaks stretching over several micrometers in an x/y plane.	Iron	97-101	H2A.X variant histone	Homo sapiens	136-146
16511314-3	2006	When in its apo form, IRP1 binds to iron responsive elements (IREs) found in mRNAs encoding proteins of iron storage and transport and either prevents translation or degradation of the bound mRNA.	Iron	104-108	aconitase 1	Homo sapiens	22-26
16511314-4	2006	Excess cellular iron stimulates the assembly of a [4Fe-4S] cluster in IRP1, inhibiting its IRE-binding ability and converting it to an aconitase.	Iron	16-20	aconitase 1	Homo sapiens	70-74
16511314-5	2006	The three-dimensional structure of IRP1 in its different active forms will provide details of the interconversion process and clarify the selective recognition of mRNA, Fe-S sites and catalytic activity.	Iron	169-173	aconitase 1	Homo sapiens	35-39
19254567-2	2009	Patients with the most common form of hereditary iron overload have mutations in the hereditary hemochromatosis protein HFE.	Iron	49-53	homeostatic iron regulator	Homo sapiens	120-123
19254567-5	2009	We report two hepatic cell lines, WIF-B cells and HepG2 cells transfected with HFE, where hepcidin expression responded to iron-loaded transferrin.	Iron	123-127	homeostatic iron regulator	Homo sapiens	79-82
16677089-5	2006	Studies of the yeast and animal model of the disease as well as of tissues from FRDA patients have demonstrated that deficit of frataxin is associated with mitochondrial iron accumulation, increased sensitivity to oxidative stress, deficit of respiratory chain complex activities and in vivo impairment of tissue energy metabolism.	Iron	170-174	frataxin	Homo sapiens	128-136
15331444-7	2005	Histology showed iron-labeled cells around the tumor rim in labeled mice, which expressed CD31 and von Willebrand factor, indicating the transplanted cells detected in the tumor have differentiated into endothelial-like cells.	Iron	17-21	platelet/endothelial cell adhesion molecule 1	Mus musculus	90-94
19214108-2	2009	Clinical diagnosis of the disease requires phenotypic evidence of iron overload because the commonly disease-associated HFE genotypes have an incomplete penetrance.	Iron	66-70	homeostatic iron regulator	Homo sapiens	120-123
15345587-5	2005	Northern blot analyses showed that the levels of expression of hepcidin mRNA in the liver were generally lower, whereas those of duodenal DMT1, the main transporter for uptake of dietary iron, were higher in the TfR2-mutant mice as compared to the wild-type siblings.	Iron	187-191	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	138-142
16677095-3	2006	Mutant cells are deficient in the ISC-requiring mitochondrial enzymes aconitase and succinate dehydrogenase, but not in the non-ISC mitochondrial enzyme citrate synthase; also, the mitochondrial iron-sulfur scaffold protein IscU2 co-immunoprecipitates with frataxin in vivo.	Iron	195-199	frataxin	Homo sapiens	257-265
16446107-1	2006	Mutations in aminolevulinate synthase 2 (ALAS2) are usually associated with sideroblastic anemia and iron overload.	Iron	101-105	5'-aminolevulinate synthase 2	Homo sapiens	41-46
19214108-8	2009	In conclusion, clinical suspicion of hemochromatosis and elevated serum iron parameters should prompt HFE genotyping for C282Y and H63D.	Iron	72-76	homeostatic iron regulator	Homo sapiens	102-105
19438058-8	2009	Switching the preparation solution increased the supported nanoscale iron"s BET surface area and Fe content from 31.63 m2 g(-1) and 18.19 mg Fe g(-1) to 38.10 m2 g(-1) and 22.44 mg Fe g(-1), respectively.	Iron	69-73	delta/notch like EGF repeat containing	Homo sapiens	76-79
16446107-2	2006	The objective of this study was to determine if "mild" mutations in ALAS2 might increase the severity of primary iron overload.	Iron	113-117	5'-aminolevulinate synthase 2	Homo sapiens	68-73
16446107-3	2006	Direct sequencing of the ALAS2 gene was performed on 24 subjects with primary hemochromatosis and one subject with sideroblastic anemia with severe iron overload.	Iron	148-152	5'-aminolevulinate synthase 2	Homo sapiens	25-30
16446107-10	2006	Thus, ALAS2 mutations might contribute to more severe iron loading in persons with primary hemochromatosis.	Iron	54-58	5'-aminolevulinate synthase 2	Homo sapiens	6-11
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	172-176	superoxide dismutase 2	Homo sapiens	0-30
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	172-176	superoxide dismutase 2	Homo sapiens	32-37
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	196-200	superoxide dismutase 2	Homo sapiens	0-30
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	196-200	superoxide dismutase 2	Homo sapiens	32-37
15607698-1	2005	Before the discovery of HFE, reports suggested that hemochromatosis patients with the ancestral haplotype (or some element thereof) have more severe iron overload than those without the haplotype.	Iron	149-153	homeostatic iron regulator	Homo sapiens	24-27
16305465-5	2005	The structure of TfR1 and its role in the process of receptor-mediated cellular uptake of iron are presented together with structural information on the iron storage protein ferritin.	Iron	90-94	transferrin receptor	Homo sapiens	17-21
16305465-5	2005	The structure of TfR1 and its role in the process of receptor-mediated cellular uptake of iron are presented together with structural information on the iron storage protein ferritin.	Iron	153-157	transferrin receptor	Homo sapiens	17-21
15654232-4	2005	CONCLUSIONS: The HFE gene test confirmed a genetic defect that may lead to iron loading in individuals when iron parameter values, especially for the C282Y/C282Y, were still low as well as for genotypes usually associated with low expressivity and penetrance (C282Y/H63D, H63D/H63D).	Iron	75-79	homeostatic iron regulator	Homo sapiens	17-20
15654232-4	2005	CONCLUSIONS: The HFE gene test confirmed a genetic defect that may lead to iron loading in individuals when iron parameter values, especially for the C282Y/C282Y, were still low as well as for genotypes usually associated with low expressivity and penetrance (C282Y/H63D, H63D/H63D).	Iron	108-112	homeostatic iron regulator	Homo sapiens	17-20
15642666-10	2005	Based on these results, a new hypothesis is advanced, proposing that the HFE protein in involved as a sensor of systemic iron availability, via the soluble transferrin receptor.	Iron	121-125	homeostatic iron regulator	Homo sapiens	73-76
19438058-8	2009	Switching the preparation solution increased the supported nanoscale iron"s BET surface area and Fe content from 31.63 m2 g(-1) and 18.19 mg Fe g(-1) to 38.10 m2 g(-1) and 22.44 mg Fe g(-1), respectively.	Iron	141-143	delta/notch like EGF repeat containing	Homo sapiens	76-79
15642666-10	2005	Based on these results, a new hypothesis is advanced, proposing that the HFE protein in involved as a sensor of systemic iron availability, via the soluble transferrin receptor.	Iron	121-125	transferrin receptor	Homo sapiens	156-176
16503547-1	2006	BACKGROUND AND OBJECTIVES: The functions of the iron regulatory proteins (IRP1 and IRP2), which control cellular iron homeostasis are similar but not identical.	Iron	48-52	aconitase 1	Homo sapiens	74-78
16503547-1	2006	BACKGROUND AND OBJECTIVES: The functions of the iron regulatory proteins (IRP1 and IRP2), which control cellular iron homeostasis are similar but not identical.	Iron	113-117	aconitase 1	Homo sapiens	74-78
19438058-8	2009	Switching the preparation solution increased the supported nanoscale iron"s BET surface area and Fe content from 31.63 m2 g(-1) and 18.19 mg Fe g(-1) to 38.10 m2 g(-1) and 22.44 mg Fe g(-1), respectively.	Iron	141-143	delta/notch like EGF repeat containing	Homo sapiens	76-79
19152427-2	2009	However, in hereditary hemochromatosis, a common iron-overloading disorder associated with mutations in the HFE gene, iron in plasma exceeds transferrin-binding capacity, and non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload.	Iron	49-53	homeostatic iron regulator	Homo sapiens	108-111
16638105-1	2006	BACKGROUND AND AIM: Mutations in the hemochromatosis (HFE) gene are carried by one in three individuals of British Isles descent and may result in increased iron stores.	Iron	157-161	homeostatic iron regulator	Homo sapiens	54-57
19152427-2	2009	However, in hereditary hemochromatosis, a common iron-overloading disorder associated with mutations in the HFE gene, iron in plasma exceeds transferrin-binding capacity, and non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload.	Iron	118-122	homeostatic iron regulator	Homo sapiens	108-111
19152427-2	2009	However, in hereditary hemochromatosis, a common iron-overloading disorder associated with mutations in the HFE gene, iron in plasma exceeds transferrin-binding capacity, and non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload.	Iron	118-122	homeostatic iron regulator	Homo sapiens	108-111
16424878-7	2006	Iron was increased up to 2-fold in hair of keratin 14-human transferrin receptor (hTfR) transgenics and 30% in Inv-hTfR transgenics.	Iron	0-4	transferrin receptor	Homo sapiens	82-86
19152427-2	2009	However, in hereditary hemochromatosis, a common iron-overloading disorder associated with mutations in the HFE gene, iron in plasma exceeds transferrin-binding capacity, and non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload.	Iron	118-122	homeostatic iron regulator	Homo sapiens	108-111
16424878-7	2006	Iron was increased up to 2-fold in hair of keratin 14-human transferrin receptor (hTfR) transgenics and 30% in Inv-hTfR transgenics.	Iron	0-4	involucrin	Mus musculus	111-114
16424878-7	2006	Iron was increased up to 2-fold in hair of keratin 14-human transferrin receptor (hTfR) transgenics and 30% in Inv-hTfR transgenics.	Iron	0-4	transferrin receptor	Homo sapiens	115-119
19152427-4	2009	Lipocalin 2 (Lcn2), a secreted protein of the lipocalin family, has emerged as the mediator of an alternative, transferrin-independent pathway for cellular iron delivery.	Iron	156-160	lipocalin 2	Mus musculus	0-11
16424878-10	2006	These data show that control of transferrin receptor expression is sufficient to regulate iron content in proliferating or differentiating keratinocytes in the epidermis.	Iron	90-94	transferrin receptor	Mus musculus	32-52
19152427-4	2009	Lipocalin 2 (Lcn2), a secreted protein of the lipocalin family, has emerged as the mediator of an alternative, transferrin-independent pathway for cellular iron delivery.	Iron	156-160	lipocalin 2	Mus musculus	13-17
19252502-6	2009	Owing to the heightened iron demand in osteoclast development, transferrin receptor 1 (TfR1) expression was induced post-transcriptionally via iron regulatory protein 2.	Iron	24-28	transferrin receptor	Mus musculus	63-85
16354665-2	2006	The sTfR reflects the iron demand of the body and is postulated as a regulator of iron homeostasis via binding to the hereditary hemochromatosis protein HFE.	Iron	22-26	homeostatic iron regulator	Homo sapiens	153-156
16354665-2	2006	The sTfR reflects the iron demand of the body and is postulated as a regulator of iron homeostasis via binding to the hereditary hemochromatosis protein HFE.	Iron	82-86	homeostatic iron regulator	Homo sapiens	153-156
19252502-6	2009	Owing to the heightened iron demand in osteoclast development, transferrin receptor 1 (TfR1) expression was induced post-transcriptionally via iron regulatory protein 2.	Iron	24-28	transferrin receptor	Mus musculus	87-91
19000667-2	2009	BACKGROUND: A decrease in the serum concentrations of the soluble transferrin receptor (sTfR) is considered a good index of tissue iron.	Iron	131-135	transferrin receptor	Homo sapiens	66-86
20031565-0	2009	HFE C282Y homozygosity is associated with lower total and low-density lipoprotein cholesterol: The hemochromatosis and iron overload screening study.	Iron	119-123	homeostatic iron regulator	Homo sapiens	0-3
19066835-3	2009	TfR mediates iron accumulation and reactive oxygen formation and thereby enhanced proliferation in clonal human glioma lines, as shown by the following experiments: (1) downregulating TfR expression reduced proliferation in vitro and in vivo; (2) forced TfR expression in low-grade glioma accelerated proliferation to the level of high-grade glioma; (3) iron and oxidant chelators attenuated tumor proliferation in vitro and tumor size in vivo.	Iron	13-17	transferrin receptor	Homo sapiens	0-3
19238984-4	2009	The following reactions occurred in parallel or consecutively: (i) 2-CIBP is promptly and completely sequestrated to RAC phase, (ii) the adsorbed 2-CIBP is almost simultaneously dechlorinated by Fe/Pd particles to form a reaction product biphenyl (BP), and (iii) the BP formed is instantly and strongly adsorbed to RAC.	Iron	195-197	calcium and integrin binding 1	Homo sapiens	148-152
19378307-3	2009	Spectroscopic and computational studies establish a triplet ground state for [{Fe(tim)}(2)] and suggest a mixed-valence compound with respect to both the Fe ions and the ligands.	Iron	79-81	Rho guanine nucleotide exchange factor 5	Homo sapiens	82-85
18823803-4	2009	Genetic analyses identified a novel mutation in the iron responsive element of the ALAS2 gene.	Iron	52-56	5'-aminolevulinate synthase 2	Homo sapiens	83-88
18823803-6	2009	We suggest that the ALAS2 mutation together with chronic hepatitis C infection may have caused the severe iron overload phenotype.	Iron	106-110	5'-aminolevulinate synthase 2	Homo sapiens	20-25
19294884-3	2009	Frataxin deficiency leads to progressive iron accumulation in mitochondria, excessive free radical production and dysfunction of respiratory chain complexes.	Iron	41-45	frataxin	Homo sapiens	0-8
19601789-2	2009	In recent studies, iron binding species such as desferrioxamine, triapine, tachpyridine, Dp44Mt, and PIH have been tested in cell line tests and clinical trials.	Iron	19-23	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	101-104
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	18-22	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
19858116-6	2009	Total nutrient accumulation was similar between lines, but grain Fe, Zn, and N were at lower concentrations in the NAM knockdown line.	Iron	65-67	NAC domain-containing protein 20	Triticum aestivum	115-118
18946492-5	2009	Our results show that the effect of anti-hTfR IgG3-Av is iron-dependent whereas that of GA is iron-independent in all cells tested.	Iron	57-61	transferrin receptor	Homo sapiens	41-45
18563875-6	2008	The calculations show that azole binding is a stepwise mechanism whereby first the water molecule from the resting state of P450 is released from the sixth binding site of the heme to create a pentacoordinated active site followed by coordination of the azole nitrogen to the heme iron.	Iron	281-285	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	124-128
19050270-5	2008	Lcn2 inhibits the in vitro growth of mycobacteria through sequestration of iron uptake.	Iron	75-79	lipocalin 2	Mus musculus	0-4
18930916-5	2008	We identified a mutation (N44I) in the vacuolar zinc transporter ZRC1 that changed the substrate specificity of the transporter from zinc to iron.	Iron	141-145	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	65-69
19058322-11	2008	An increase in the iron saturation of plasma transferrin leads to displacement of TfR1 from HFE and assembly of the putative iron-sensing complex.	Iron	19-23	transferrin receptor	Homo sapiens	82-86
19058322-11	2008	An increase in the iron saturation of plasma transferrin leads to displacement of TfR1 from HFE and assembly of the putative iron-sensing complex.	Iron	19-23	homeostatic iron regulator	Homo sapiens	92-95
19021541-7	2008	The APP IRE is homologous with the canonical IRE RNA stem-loop that binds the iron regulatory proteins (IRP1 and IRP2) to control intracellular iron homoeostasis by modulating ferritin mRNA translation and transferrin receptor mRNA stability.	Iron	78-82	aconitase 1	Homo sapiens	104-108
19021541-7	2008	The APP IRE is homologous with the canonical IRE RNA stem-loop that binds the iron regulatory proteins (IRP1 and IRP2) to control intracellular iron homoeostasis by modulating ferritin mRNA translation and transferrin receptor mRNA stability.	Iron	78-82	transferrin receptor	Homo sapiens	206-226
19021547-1	2008	Ferritin, a symmetrical 24-subunit heteropolymer composed of heavy and light chains, is the primary iron-storage molecule in bacteria, plants and animals.	Iron	100-104	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
16240673-8	2005	The results therefore suggest that both Fe and Zn isotopic signatures in whole blood, at least to some extent, reflect polymorphisms in the HFE gene.	Iron	40-42	homeostatic iron regulator	Homo sapiens	140-143
19046159-0	2008	Mutation in the abcb7 gene causes abnormal iron and fatty acid metabolism in developing medaka fish.	Iron	43-47	ATP-binding cassette sub-family B member 7, mitochondrial	Oryzias latipes	16-21
16350822-5	2005	RESULTS: Sixty-five min after IV iron application, there was a significant increase in plasma PAPP-A (from 36.0+/-9.9 to 79.6+/-28.9 mU/L, p&lt;0.0001).	Iron	33-37	pappalysin 1	Homo sapiens	94-100
16350822-7	2005	CONCLUSION: IV iron increases circulating PAPP-A, and in this way, it might contribute to more pronounced cardiovascular complications in HD patients.	Iron	15-19	pappalysin 1	Homo sapiens	42-48
19046159-4	2008	Abcb7, a mitochondrial ABC (ATP binding cassette) half-transporter, has been implicated in iron metabolism.	Iron	91-95	ATP-binding cassette sub-family B member 7, mitochondrial	Oryzias latipes	0-5
15642259-0	2005	Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration.	Iron	114-118	lipocalin 2	Mus musculus	0-18
19046159-7	2008	Microarray and in situ hybridization analyses demonstrated that the expression of genes involved in iron and lipid metabolisms are both affected in the mutant liver, suggesting novel roles of Abcb7 in the development of physiologically functional liver.	Iron	100-104	ATP-binding cassette sub-family B member 7, mitochondrial	Oryzias latipes	192-197
18839983-1	2008	The adsorption of a metallo-supramolecular coordination polymer (Fe-MEPE) in the cylindrical pores of SBA-15 silica with pure and carboxylic acid (CA) carrying pore walls has been studied.	Iron	65-67	matrix extracellular phosphoglycoprotein	Homo sapiens	68-72
18839983-3	2008	The adsorption affinity and kinetics of the Fe-MEPE chains is strongly enhanced when the pore walls are doped with CA, and when the pH of the aqueous medium or temperature is increased.	Iron	44-46	matrix extracellular phosphoglycoprotein	Homo sapiens	47-51
16437160-1	2006	In the budding yeast Saccharomyces cerevisiae, transcription of genes encoding for the high-affinity iron (FET3, FTR1) and copper (CTR1) transporters does not occur in the absence of heme.	Iron	101-105	ferroxidase FET3	Saccharomyces cerevisiae S288C	107-111
18586688-10	2008	Selective expression of Tfrc in proliferative lesions suggests an involvement of changes in iron homeostasis during the process of tumor promotion/progression driven by FB or PB.	Iron	92-96	transferrin receptor	Rattus norvegicus	24-28
16446425-5	2006	However, we found that Lcn2-/- mice exhibited an increased susceptibility to bacterial infections, in keeping with the proposed function of lipocalin 2 in iron sequestration.	Iron	155-159	lipocalin 2	Mus musculus	23-27
16446425-5	2006	However, we found that Lcn2-/- mice exhibited an increased susceptibility to bacterial infections, in keeping with the proposed function of lipocalin 2 in iron sequestration.	Iron	155-159	lipocalin 2	Mus musculus	140-151
16446425-7	2006	The bacteriostatic property of the WT neutrophils was abolished by the addition of exogenous iron, indicating that the main function of lipocalin 2 in the antibacterial innate immune response is to limit this essential element.	Iron	93-97	lipocalin 2	Mus musculus	136-147
18931788-8	2008	One of the most prominent changes was in the extracellular iron carrier, Transferrin (Tsf1).	Iron	59-63	Transferrin 1	Drosophila melanogaster	73-84
16393683-7	2006	Patients with a wild-type genotype (lacking HFE variants) and elevated IBS were far more likely to have an iron binding capacity less than 250 microg/dL (&lt;44.8 micromol/L) than those with saturation values less than 45%, suggesting that a significant percentage of elevated IBS test results in liver disease are false-positives associated with decreased synthetic capacity.	Iron	107-111	homeostatic iron regulator	Homo sapiens	44-47
18931788-8	2008	One of the most prominent changes was in the extracellular iron carrier, Transferrin (Tsf1).	Iron	59-63	Transferrin 1	Drosophila melanogaster	86-90
18931788-10	2008	Increasing Tsf1 in wild-type embryos blocked ventral furrow formation and caused proteome changes that were similar to the previously seen ventral-specific difference-proteins, including Pros35, which indicates the existence of an unprecedented regulatory loop between the proteasome and iron homeostasis.	Iron	288-292	Transferrin 1	Drosophila melanogaster	11-15
16454835-9	2006	(4) Stainable liver iron was present in 52% of patients; grade was greater in patients with two HFE mutations than in those with one or with none.	Iron	20-24	homeostatic iron regulator	Homo sapiens	96-99
16454835-12	2006	HFE mutations, although modestly influencing liver iron, do not predispose to clinically significant ALD.	Iron	51-55	homeostatic iron regulator	Homo sapiens	0-3
18523150-0	2008	Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis.	Iron	83-87	transmembrane serine protease 6	Mus musculus	31-43
15967479-5	2006	Maximum COD removal rates (up to 72%) were achieved by the addition of 7 mM Fe, or of 11 mM Al respectively.	Iron	76-78	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	8-11
16629171-0	2006	Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis.	Iron	86-90	homeostatic iron regulator	Homo sapiens	58-61
16629171-6	2006	The mechanism by which HFE influences iron homeostasis in cells and in the body remains elusive.	Iron	38-42	homeostatic iron regulator	Homo sapiens	23-26
18523150-0	2008	Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis.	Iron	83-87	transmembrane serine protease 6	Mus musculus	45-52
16629171-10	2006	This review gives the background and a model as to possible mechanisms of how HFE could exert different effects on iron homeostasis in different cell types.	Iron	115-119	homeostatic iron regulator	Homo sapiens	78-81
18523150-3	2008	Here we show that matriptase-2 (Tmprss6), a recently described member of the TTSP family, is an essential regulator of iron homeostasis.	Iron	119-123	transmembrane serine protease 6	Mus musculus	18-30
16629172-6	2006	The majority of patients with hereditary hemochromatosis display mutations in the gene coding for HFE, a protein that normally acts as an inhibitor of transepithelial iron transport.	Iron	167-171	homeostatic iron regulator	Homo sapiens	98-101
16629180-2	2006	A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding the transcription factor USF2 failed to produce Hepc mRNA and developed spontaneous visceral iron overload.	Iron	26-30	upstream transcription factor 2	Mus musculus	149-153
16629180-2	2006	A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding the transcription factor USF2 failed to produce Hepc mRNA and developed spontaneous visceral iron overload.	Iron	217-221	upstream transcription factor 2	Mus musculus	149-153
18523150-3	2008	Here we show that matriptase-2 (Tmprss6), a recently described member of the TTSP family, is an essential regulator of iron homeostasis.	Iron	119-123	transmembrane serine protease 6	Mus musculus	32-39
18523150-5	2008	These hematologic alterations found in Tmprss6(-/-) mice are accompanied by a marked up-regulation of hepcidin, a negative regulator of iron export into plasma.	Iron	136-140	transmembrane serine protease 6	Mus musculus	39-46
18523150-6	2008	Likewise, Tmprss6(-/-) mice have reduced ferroportin expression in the basolateral membrane of enterocytes and accumulate iron in these cells.	Iron	122-126	transmembrane serine protease 6	Mus musculus	10-17
18523150-8	2008	On the basis of these findings, we conclude that matriptase-2 activity represents a novel and relevant step in hepcidin regulation and iron homeostasis.	Iron	135-139	transmembrane serine protease 6	Mus musculus	49-61
16257244-1	2006	Hereditary hemochromatosis is a common disorder of iron metabolism most frequently associated with mutations in the HFE gene.	Iron	51-55	homeostatic iron regulator	Homo sapiens	116-119
18760763-0	2008	C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload.	Iron	125-129	5'-aminolevulinate synthase 2	Homo sapiens	28-33
16681427-2	2006	This study focused on the change in cholesteryl esters in plasma lipoproteins under oxidative stress resulting from iron overload in beta-thalassemia/hemoglobin E (beta-thal/Hb E) patients.	Iron	116-120	hemoglobin subunit epsilon 1	Homo sapiens	174-178
16681427-5	2006	RESULTS: beta-Thal/Hb E patients presented iron overload, a precipitous decrease in alpha-tocopherol and increased lipid peroxidation (thiobarbituric acid-reactive substances; TBARs) in both plasma and lipoproteins.	Iron	43-47	hemoglobin subunit epsilon 1	Homo sapiens	19-23
17181986-0	2006	Iron Overload (with Attention to Genetic Testing and Diagnosis/Management of HFE Wild Type Patients).	Iron	0-4	homeostatic iron regulator	Homo sapiens	77-80
18565178-2	2008	OBJECTIVES: To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes.	Iron	271-275	homeostatic iron regulator	Homo sapiens	47-50
17181986-1	2006	The discovery of the HFE, HJV, HAMP, TfR2, and SLC40A1 genes and preliminary understanding of their roles in iron homeostasis have contributed tremendously to our understanding of the pathogenesis of genetic hemochromatosis.	Iron	109-113	homeostatic iron regulator	Homo sapiens	21-24
17181986-3	2006	A diagnosis of non-HFE genetic hemochromatosis should be considered in patients with unexplained iron overload who do not have the common mutations in the HFE genes.	Iron	97-101	homeostatic iron regulator	Homo sapiens	19-22
18586377-10	2008	CONCLUSION: The expression of TfR1, ferritin and FP1 in the human term placenta tissues showed different trend of change with different maternal iron status.	Iron	145-149	transferrin receptor	Homo sapiens	30-34
16706826-0	2006	Role of transferrin receptor 2 in hepatic accumulation of iron in patients with chronic hepatitis C. BACKGROUND AND AIM: Iron deposition in the liver is a common finding in patients with chronic hepatitis C (CH-C).	Iron	121-125	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	208-212
16706826-10	2006	CONCLUSIONS: The protein expression of TfR2 is significantly associated with iron deposition in the liver in patients with CH-C.	Iron	77-81	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	123-127
18697928-8	2008	A "metascreen" of previously collected ionomic data from 880 Arabidopsis mutants and natural accessions for this Fe response signature successfully identified the known Fe mutants frd1 and frd3.	Iron	113-115	ferric reduction oxidase 2	Arabidopsis thaliana	180-184
16326028-7	2006	TfR imports iron into cells, an event necessary for DNA synthesis and cell growth.	Iron	12-16	transferrin receptor	Homo sapiens	0-3
16326028-9	2006	Based on this, we propose that one molecular mechanism by which 11q23 deletions confer a poor prognosis in CLL is via increased TfR expression secondary to ATM loss, resulting in the increased cellular iron import, and hence increased capacity for malignant growth.	Iron	202-206	transferrin receptor	Homo sapiens	128-131
16326028-10	2006	Our hypothesis may also partially explain why gallium, an atomically iron-like toxic metal that binds to transferrin and the TfR is incorporated into cells and was previously demonstrated to have anti-tumor activity in patients with lymphomas refractory to other chemotherapeutic treatments.	Iron	69-73	transferrin receptor	Homo sapiens	125-128
18385176-7	2008	These effects were prevented by the co-incubation with the cell-permeating iron salt ferric nitrilotriacetate, which caused an increase of intracellular iron bioavailability, measured as increased activity of the iron regulatory protein-1.	Iron	75-79	aconitase 1	Homo sapiens	213-238
16464747-6	2006	Consequently performed mutation analyses in genes involved in brain iron metabolism lead to the discovery of specific mutations in the ferritin-H, IRP2 and HFE gene in single PD patients.	Iron	68-72	homeostatic iron regulator	Homo sapiens	156-159
18560379-5	2008	Computer-based protein modelling indicated that hereditary haemochromatosis protein (HFE), a molecule involved in iron uptake, was most similar.	Iron	114-118	homeostatic iron regulator	Homo sapiens	85-88
16286504-4	2005	Ablating SLC11A2, the gene for the divalent metal ion transporter DMT1, supports evidence from the Belgrade rat and mk mouse models establishing DMT1 as the primary mechanism serving apical uptake of nonheme iron.	Iron	208-212	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	145-149
18524764-0	2008	The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells.	Iron	54-58	homeostatic iron regulator	Homo sapiens	40-43
18524764-0	2008	The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells.	Iron	54-58	solute carrier family 39 member 14	Homo sapiens	89-94
15927188-8	2005	Two weeks after Ad-FasL transfer, non-thrombotic rupture, intra-plaque haemorrhage, buried caps and iron deposits were observed in 6 out of 17 Ad-FasL-treated carotid arteries versus 0 out of 17 controls (P=0.009), indicative of enhanced plaque vulnerability.	Iron	100-104	Fas ligand (TNF superfamily, member 6)	Mus musculus	146-150
15563524-7	2004	Overexpression of mouse Tfr1, mouse Tfr2, and zebrafish tfr1b partially rescued hypochromia in cia embryos, establishing that each of these transferrin receptors are capable of supporting iron uptake for hemoglobin production in vivo.	Iron	188-192	transferrin receptor	Mus musculus	24-28
18524764-1	2008	Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of HFE expression in the liver.	Iron	67-71	homeostatic iron regulator	Homo sapiens	55-58
16092918-1	2005	TfR1 (transferrin receptor 1) mediates the uptake of transferrin-bound iron and thereby plays a critical role in cellular iron metabolism.	Iron	71-75	transferrin receptor	Homo sapiens	0-4
16092918-1	2005	TfR1 (transferrin receptor 1) mediates the uptake of transferrin-bound iron and thereby plays a critical role in cellular iron metabolism.	Iron	71-75	transferrin receptor	Homo sapiens	6-28
18524764-1	2008	Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of HFE expression in the liver.	Iron	67-71	homeostatic iron regulator	Homo sapiens	129-132
16092918-1	2005	TfR1 (transferrin receptor 1) mediates the uptake of transferrin-bound iron and thereby plays a critical role in cellular iron metabolism.	Iron	122-126	transferrin receptor	Homo sapiens	0-4
15785438-1	2004	AIM: HFE gene is associated to haemochromatosis, an inherited autosomal recessive disorder responsible of an overload of iron in intestine, liver, pancreas, heart, cutis and joints.	Iron	121-125	homeostatic iron regulator	Homo sapiens	5-8
16092918-1	2005	TfR1 (transferrin receptor 1) mediates the uptake of transferrin-bound iron and thereby plays a critical role in cellular iron metabolism.	Iron	122-126	transferrin receptor	Homo sapiens	6-28
18524764-2	2008	In this study, we investigated the role of HFE in the regulation of both transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI) uptake in HepG2 cells, a human hepatoma cell line.	Iron	91-95	homeostatic iron regulator	Homo sapiens	43-46
15539473-9	2004	We propose a new model for iron uptake in Arabidopsis where FRO2 and IRT1 are differentially regulated by FIT1.	Iron	27-31	ferric reduction oxidase 2	Arabidopsis thaliana	60-64
18524764-2	2008	In this study, we investigated the role of HFE in the regulation of both transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI) uptake in HepG2 cells, a human hepatoma cell line.	Iron	128-132	homeostatic iron regulator	Homo sapiens	43-46
18572962-4	2008	Among them, a ubiquitous and highly conserved iron-binding protein, Ferritin, was further characterized as a modulator for the expression of a TLR2-specific cytokine IL-10 in murine macrophage cells by using small-interfering RNA (siRNA).	Iron	46-50	toll-like receptor 2	Mus musculus	143-147
15337768-8	2004	FA2H also contains the iron-binding histidine motif conserved among membrane-bound desaturases/hydroxylases.	Iron	23-27	fatty acid 2-hydroxylase	Homo sapiens	0-4
15322079-4	2004	In one structure obtained under reducing conditions, the iron-bridging ligand Glu-267 adopts the mu-(eta1,eta2) coordination mode, which has previously been related to O2 activation, and an acetate ion from the soaking solution is observed where O2 has been proposed to bind the iron.	Iron	57-61	secreted phosphoprotein 1	Mus musculus	101-105
16330325-0	2005	A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.	Iron	19-23	SMAD family member 4	Homo sapiens	10-15
16330325-3	2005	Here, we show that a Cre-loxP-mediated liver-specific disruption of SMAD4 results in markedly decreased hepcidin expression and accumulation of iron in many organs, which is most pronounced in liver, kidney, and pancreas.	Iron	144-148	SMAD family member 4	Homo sapiens	68-73
16330325-7	2005	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis.	Iron	104-108	SMAD family member 4	Homo sapiens	44-49
16330325-7	2005	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis.	Iron	123-127	SMAD family member 4	Homo sapiens	44-49
16306377-1	2005	To determine whether the HFE gene variants H63D and C282Y are associated with body iron stores and the risk of type 2 diabetes, we conducted a nested case-control study of 714 incident cases of type 2 diabetes and 1,120 matching control subjects in a prospective cohort, the Nurses" Health Study.	Iron	83-87	homeostatic iron regulator	Homo sapiens	25-28
18555617-5	2008	The levels of iron regulatory factors, including transferrin receptor 1 (TfR1), ferritin (Fn), and iron regulatory protein1 (IRP1), were all changed in the iron deposition regions of the PS-exposed rat brain, accompanied by intensified oxidative stress.	Iron	14-18	transferrin receptor	Rattus norvegicus	49-71
16306377-6	2005	In addition, we found a significant interaction between HFE variants and heme iron intake (P for interaction = 0.029).	Iron	78-82	homeostatic iron regulator	Homo sapiens	56-59
16283625-7	2005	For both Irp genes, Cre-assisted deletion of exon 3 generates complete null alleles that, in the case of IRP2, are associated with altered body iron distribution and compromised hematopoiesis.	Iron	144-148	wingless-type MMTV integration site family, member 2	Mus musculus	9-12
16314508-1	2005	The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1.	Iron	38-42	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	281-285
16314508-1	2005	The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1.	Iron	51-53	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	281-285
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	148-152	transferrin receptor	Rattus norvegicus	40-60
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	148-152	transferrin receptor	Rattus norvegicus	62-65
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	157-159	transferrin receptor	Rattus norvegicus	40-60
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	157-159	transferrin receptor	Rattus norvegicus	62-65
16137791-2	2005	Recent studies demonstrated that nerve growth factor (NGF)-treated PC12 cells (the neuronal phenotype) have higher NTBI as well as Tf-Fe uptake compared with untreated cells (the undifferentiated cells).	Iron	134-136	nerve growth factor	Rattus norvegicus	33-52
16137791-2	2005	Recent studies demonstrated that nerve growth factor (NGF)-treated PC12 cells (the neuronal phenotype) have higher NTBI as well as Tf-Fe uptake compared with untreated cells (the undifferentiated cells).	Iron	134-136	nerve growth factor	Rattus norvegicus	54-57
16137791-3	2005	We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR.	Iron	40-42	nerve growth factor	Rattus norvegicus	61-64
16137791-3	2005	We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR.	Iron	40-42	transferrin receptor	Rattus norvegicus	137-140
16203742-1	2005	The mitochondrial iron chaperone, frataxin, plays a critical role in cellular iron homeostasis and the synthesis and regeneration of Fe-S centers.	Iron	18-22	frataxin	Drosophila melanogaster	34-42
16203742-1	2005	The mitochondrial iron chaperone, frataxin, plays a critical role in cellular iron homeostasis and the synthesis and regeneration of Fe-S centers.	Iron	78-82	frataxin	Drosophila melanogaster	34-42
16203742-1	2005	The mitochondrial iron chaperone, frataxin, plays a critical role in cellular iron homeostasis and the synthesis and regeneration of Fe-S centers.	Iron	133-137	frataxin	Drosophila melanogaster	34-42
16203742-2	2005	Genetic insufficiency for frataxin is associated with Friedreich"s Ataxia in humans and confers loss of function of Fe-containing proteins including components of the respiratory chain and mitochondrial and cytosolic aconitases.	Iron	116-118	frataxin	Homo sapiens	26-34
16274220-2	2005	Mutations in the murine hephaestin gene (sla) produce microcytic, hypochromic anemia that is refractory to oral iron therapy.	Iron	112-116	hephaestin	Mus musculus	24-34
16833294-4	2005	The coordination environment of Fe was determined using EPR and UV-vis/DRS.	Iron	32-34	sushi repeat containing protein X-linked	Homo sapiens	71-74
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	12-16	insulin receptor	Homo sapiens	120-136
16225476-5	2005	CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease.	Iron	331-335	insulin receptor	Homo sapiens	120-136
16154780-1	2005	The mechanism of excessive iron storage in patients with hereditary hemochromatosis caused by mutations of the HFE gene seems to be a failure to up-regulate hepcidin in the face of increased body iron.	Iron	27-31	homeostatic iron regulator	Homo sapiens	111-114
16154780-1	2005	The mechanism of excessive iron storage in patients with hereditary hemochromatosis caused by mutations of the HFE gene seems to be a failure to up-regulate hepcidin in the face of increased body iron.	Iron	196-200	homeostatic iron regulator	Homo sapiens	111-114
16737093-1	2005	Recent advances in molecular genetics have led to a better understanding of hereditary iron overload syndromes, of which the most frequent are recessive HFE-hemochromatosis and, to a much lesser extent, dominant ferroportin disease.	Iron	87-91	homeostatic iron regulator	Homo sapiens	153-156
16222171-0	2005	HFE genotype modifies the influence of heme iron intake on iron status.	Iron	44-48	homeostatic iron regulator	Homo sapiens	0-3
16222171-0	2005	HFE genotype modifies the influence of heme iron intake on iron status.	Iron	59-63	homeostatic iron regulator	Homo sapiens	0-3
16269021-1	2005	BACKGROUND: Friedreich"s ataxia (FRDA) is a neurodegenerative disorder caused by decreased expression of the protein frataxin, recently described to be an iron chaperone for the assembly of iron-sulphur clusters in the mitochondria, causing iron accumulation in mitochondria, oxidative stress and cell damage.	Iron	155-159	frataxin	Homo sapiens	117-125
16269021-1	2005	BACKGROUND: Friedreich"s ataxia (FRDA) is a neurodegenerative disorder caused by decreased expression of the protein frataxin, recently described to be an iron chaperone for the assembly of iron-sulphur clusters in the mitochondria, causing iron accumulation in mitochondria, oxidative stress and cell damage.	Iron	190-194	frataxin	Homo sapiens	117-125
16269021-1	2005	BACKGROUND: Friedreich"s ataxia (FRDA) is a neurodegenerative disorder caused by decreased expression of the protein frataxin, recently described to be an iron chaperone for the assembly of iron-sulphur clusters in the mitochondria, causing iron accumulation in mitochondria, oxidative stress and cell damage.	Iron	190-194	frataxin	Homo sapiens	117-125
21783621-3	2005	In mice made susceptible to uroporphyria through a targeted deletion of one allele of uroporphyrinogen decarboxylase (Uro-D+/-), an iron deficient diet prevented the development of the uroporphyria and the changes in associated parameters normally seen within three weeks following a single exposure to Aroclor 1254.	Iron	132-136	uroporphyrinogen decarboxylase	Mus musculus	86-116
21783621-3	2005	In mice made susceptible to uroporphyria through a targeted deletion of one allele of uroporphyrinogen decarboxylase (Uro-D+/-), an iron deficient diet prevented the development of the uroporphyria and the changes in associated parameters normally seen within three weeks following a single exposure to Aroclor 1254.	Iron	132-136	uroporphyrinogen decarboxylase	Mus musculus	118-123
21783621-4	2005	Iron deprivation also completely prevented PCB-induced uroporphyria in mice wild-type at the Uro-D locus (Uro-D+/+), a model that requires delta-aminolevulinic acid administration for the development of uroporphyria.	Iron	0-4	uroporphyrinogen decarboxylase	Mus musculus	93-98
21783621-4	2005	Iron deprivation also completely prevented PCB-induced uroporphyria in mice wild-type at the Uro-D locus (Uro-D+/+), a model that requires delta-aminolevulinic acid administration for the development of uroporphyria.	Iron	0-4	uroporphyrinogen decarboxylase	Mus musculus	106-111
16185064-3	2005	In this work, the time course and products of in vitro NifS-mediated iron-sulfur cluster assembly on full-length NifU and truncated forms involving only the N-terminal domain or the central and C-terminal domains have been investigated using UV-vis absorption and Mossbauer spectroscopies, coupled with analytical studies.	Iron	69-73	NFS1 cysteine desulfurase	Homo sapiens	55-59
15956281-7	2005	This study links a classic regulator of cellular iron metabolism to systemic iron homeostasis and erythropoietic TfR1 expression.	Iron	49-53	transferrin receptor	Mus musculus	113-117
15956281-8	2005	Furthermore, this work uncovers aspects of mammalian iron metabolism that can or cannot be compensated for by the expression of IRP1.	Iron	53-57	aconitase 1	Homo sapiens	128-132
16040738-5	2005	These experiments reveal that, in ferric SOLly GLB1, one of the histidine planes is rotated 20 degrees (+/-10 degrees ) away from a N(heme)-Fe-N(heme) axis.	Iron	140-144	non-symbiotic hemoglobin class 1	Solanum lycopersicum	47-51
16144863-8	2005	In animals fed an iron-deficient diet, IRP1 was found in the Golgi apparatus and the endoplasmic reticulum.	Iron	18-22	aconitase 1	Rattus norvegicus	39-43
16024130-6	2005	Hfe and beta2-microglobulin knockout mice have similar levels of prohepcidin protein expression as compared to wild-type mice despite increased iron stores.	Iron	144-148	beta-2 microglobulin	Mus musculus	8-27
16083989-4	2005	Under these conditions, iron was still absorbed from the duodenal lumen as divalent metal transporter-1 expressions were high, however, most of the absorbed iron was incorporated into duodenal ferritin, while ferroportin expression drastically decreased and iron transfer to the circulation was reduced.	Iron	24-28	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	75-103
16142913-1	2005	Mutations in DMT1 (Nramp2 and Slc11a2) impair iron metabolism and cause microcytic anemia.	Iron	46-50	solute carrier family 11 member 2	Sus scrofa	13-17
16142913-1	2005	Mutations in DMT1 (Nramp2 and Slc11a2) impair iron metabolism and cause microcytic anemia.	Iron	46-50	solute carrier family 11 member 2	Sus scrofa	30-37
16142913-2	2005	DMT1 is expressed at the duodenal brush border where it controls uptake of dietary iron and is present at the plasma membrane and in recycling endosomes of most cells, where it is necessary for acquisition of transferrin-associated iron.	Iron	83-87	solute carrier family 11 member 2	Sus scrofa	0-4
16142913-2	2005	DMT1 is expressed at the duodenal brush border where it controls uptake of dietary iron and is present at the plasma membrane and in recycling endosomes of most cells, where it is necessary for acquisition of transferrin-associated iron.	Iron	232-236	solute carrier family 11 member 2	Sus scrofa	0-4
16142913-2	2005	DMT1 is expressed at the duodenal brush border where it controls uptake of dietary iron and is present at the plasma membrane and in recycling endosomes of most cells, where it is necessary for acquisition of transferrin-associated iron.	Iron	232-236	transferrin	Sus scrofa	209-220
15507320-1	2004	We describe the isolation of a cDNA encoding Arabidopsis thaliana ISU1 (AtISU1), which regulates iron homeostasis in the mitochondria.	Iron	97-101	SufE/NifU family protein	Arabidopsis thaliana	66-70
15507320-1	2004	We describe the isolation of a cDNA encoding Arabidopsis thaliana ISU1 (AtISU1), which regulates iron homeostasis in the mitochondria.	Iron	97-101	SufE/NifU family protein	Arabidopsis thaliana	72-78
15509541-0	2004	Deletion of murine Smn exon 7 directed to liver leads to severe defect of liver development associated with iron overload.	Iron	108-112	survival motor neuron 1	Mus musculus	19-22
15531451-2	2004	HFE mutations, frequent in Caucasian populations, can cause increased intestinal iron absorption and thus could protect against the development of iron deficiency.	Iron	81-85	homeostatic iron regulator	Homo sapiens	0-3
15531451-3	2004	The aim of this study was to evaluate the prevalence of HFE mutations and their effect on iron metabolism in Italian celiac patients at diagnosis and after a gluten-free diet.	Iron	90-94	homeostatic iron regulator	Homo sapiens	56-59
15483146-2	2004	In this study, the bioavailabilities of calcium, zinc, and iron in S-26/SMA HMF added to HM were compared with those in HM fortified with various bovine milk proteins: alpha-lactalbumin, colostrum, caseinate, casein phosphopeptides, and whey protein concentrate.	Iron	59-63	survival of motor neuron 1, telomeric	Bos taurus	72-75
15483146-7	2004	Uptake of zinc and iron were significantly higher for HM + S-26/SMA than for the other HM + fortifiers.	Iron	19-23	survival of motor neuron 1, telomeric	Homo sapiens	64-67
15469906-9	2004	Dcytb, DMT1, Ireg1 and transferrin receptor 1 mRNA expression in the spleen and liver of mice treated with PHZ responded to the enhanced iron demand associated with the resulting stimulation of erythropoiesis.	Iron	137-141	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	7-11
15447900-0	2004	Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis.	Iron	0-4	homeostatic iron regulator	Homo sapiens	48-51
15447900-8	2004	Compound heterozygotes (those who had both HFE C282Y and H63D mutations) absorbed more nonheme (but not heme) iron from meals with high (but not low) iron bioavailability.	Iron	110-114	homeostatic iron regulator	Homo sapiens	43-46
16157744-14	2005	We hypothesize that interferon beta may exert its effect on brain atrophy in part by reducing a cascade of events that involve iron deposition as a mediator of neurotoxicity or as a disease epiphenomenon.	Iron	127-131	interferon beta 1	Homo sapiens	20-35
18555617-5	2008	The levels of iron regulatory factors, including transferrin receptor 1 (TfR1), ferritin (Fn), and iron regulatory protein1 (IRP1), were all changed in the iron deposition regions of the PS-exposed rat brain, accompanied by intensified oxidative stress.	Iron	14-18	transferrin receptor	Rattus norvegicus	73-77
15965644-2	2005	Several studies have now shown that iron overload phenotypes in such patients can be associated with uncommon HFE mutations.	Iron	36-40	homeostatic iron regulator	Homo sapiens	110-113
18555617-5	2008	The levels of iron regulatory factors, including transferrin receptor 1 (TfR1), ferritin (Fn), and iron regulatory protein1 (IRP1), were all changed in the iron deposition regions of the PS-exposed rat brain, accompanied by intensified oxidative stress.	Iron	99-103	aconitase 1	Rattus norvegicus	125-129
15965644-5	2005	Experiments using cells over-expressing wild-type HFE confirm the existence of beta2microglobulin(beta2m)/HFE and HFE/transferrin receptor 1 (TfR1) interactions, as well as the capacity of HFE to reduce transferrin-mediated iron uptake.	Iron	224-228	homeostatic iron regulator	Homo sapiens	50-53
15965644-7	2005	Moreover, the 283P HFE protein was found to have a very limited effect on the major cellular iron uptake pathway.	Iron	93-97	homeostatic iron regulator	Homo sapiens	19-22
15178542-0	2004	Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta.	Iron	39-43	Wnt family member 2	Homo sapiens	54-57
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	0-4	transferrin receptor	Homo sapiens	67-89
18579154-14	2008	This can explain why other metal-loaded transferrins or a protein such as HFE-with a lower affinity for R1 than iron-saturated transferrin but with, however, similar or higher affinities for the helical domain than the C-lobe-competes with iron-saturated transferrin in an unknown state towards interaction with R1.	Iron	112-116	homeostatic iron regulator	Homo sapiens	74-77
16113319-1	2005	The diphtheria toxin repressor (DtxR) is an important iron-dependent transcriptional regulator of known virulence genes in Corynebacterium diphtheriae.	Iron	54-58	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
16113319-1	2005	The diphtheria toxin repressor (DtxR) is an important iron-dependent transcriptional regulator of known virulence genes in Corynebacterium diphtheriae.	Iron	54-58	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
16113319-2	2005	The mycobacterial iron-dependent repressor (IdeR) is phylogenetically closely related to DtxR, with high amino acid similarity in the DNA binding and metal ion binding site domains.	Iron	18-22	MarR family transcriptional regulator	Corynebacterium diphtheriae	89-93
15482345-5	2004	Serum alanine aminotransferase, gamma-glutamyl transferase, cholesterol and triglycerides significantly decreased after iron depletion.	Iron	120-124	glutamic--pyruvic transaminase	Homo sapiens	6-30
18579154-14	2008	This can explain why other metal-loaded transferrins or a protein such as HFE-with a lower affinity for R1 than iron-saturated transferrin but with, however, similar or higher affinities for the helical domain than the C-lobe-competes with iron-saturated transferrin in an unknown state towards interaction with R1.	Iron	240-244	homeostatic iron regulator	Homo sapiens	74-77
16113319-3	2005	We have previously shown that an iron-insensitive, dominant-positive dtxR(E175K) mutant allele from Corynebacterium diphtheriae can be expressed in Mycobacterium tuberculosis and results in an attenuated phenotype in mice.	Iron	33-37	MarR family transcriptional regulator	Corynebacterium diphtheriae	69-73
16113319-8	2005	These data also suggest that mutant IdeR(D177K) has a mechanism similar to that of DtxR(E175K); iron insensitivity occurs as a result of SH3-like domain binding interactions that stabilize the intermediate form of the repressor after ancillary metal ion binding.	Iron	96-100	MarR family transcriptional regulator	Corynebacterium diphtheriae	83-87
18420243-1	2008	Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier.	Iron	84-86	transferrin receptor	Rattus norvegicus	244-264
15880641-4	2005	Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake.	Iron	8-12	homeostatic iron regulator	Homo sapiens	150-153
15880641-4	2005	Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake.	Iron	8-12	transferrin receptor	Homo sapiens	169-172
15543932-1	2004	Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR) through iron-regulatory mRNA-binding proteins (IRPs), and may additionally regulate uptake and accumulation of non-transferrin-bound iron (NTBI).	Iron	161-165	transferrin receptor	Homo sapiens	148-151
15543932-3	2004	Several iron-dependent RNA-binding activities were identified, but only IRP increased with beta-mercaptoethanol.	Iron	8-12	Wnt family member 2	Homo sapiens	72-75
15543932-4	2004	With exposures between 0 and 20 microg/ml iron, decreases in IRP binding accompanied large changes in TfR and ferritin expression, while chelation of residual iron with deferoxamine (DFO) caused a large increase in IRP binding with little additional effect on TfR or ferritin expression.	Iron	42-46	Wnt family member 2	Homo sapiens	61-64
15543932-4	2004	With exposures between 0 and 20 microg/ml iron, decreases in IRP binding accompanied large changes in TfR and ferritin expression, while chelation of residual iron with deferoxamine (DFO) caused a large increase in IRP binding with little additional effect on TfR or ferritin expression.	Iron	42-46	transferrin receptor	Homo sapiens	102-105
15543932-4	2004	With exposures between 0 and 20 microg/ml iron, decreases in IRP binding accompanied large changes in TfR and ferritin expression, while chelation of residual iron with deferoxamine (DFO) caused a large increase in IRP binding with little additional effect on TfR or ferritin expression.	Iron	42-46	Wnt family member 2	Homo sapiens	215-218
15543932-4	2004	With exposures between 0 and 20 microg/ml iron, decreases in IRP binding accompanied large changes in TfR and ferritin expression, while chelation of residual iron with deferoxamine (DFO) caused a large increase in IRP binding with little additional effect on TfR or ferritin expression.	Iron	42-46	transferrin receptor	Homo sapiens	260-263
15543932-5	2004	Cellular iron content increased beyond 4 days of exposure to iron at 20 microg/ml, when IRP binding, TfR, and ferritin had all reached stable levels.	Iron	9-13	Wnt family member 2	Homo sapiens	88-91
15543932-5	2004	Cellular iron content increased beyond 4 days of exposure to iron at 20 microg/ml, when IRP binding, TfR, and ferritin had all reached stable levels.	Iron	61-65	Wnt family member 2	Homo sapiens	88-91
15880641-7	2005	Based on previous and these data we suggest that the level of intracellular iron may regulate both TfR expression (on the post-transcriptional and the post-translational levels) and TfR trafficking/transcytosis in polarized cells.	Iron	76-80	transferrin receptor	Homo sapiens	99-102
15880641-7	2005	Based on previous and these data we suggest that the level of intracellular iron may regulate both TfR expression (on the post-transcriptional and the post-translational levels) and TfR trafficking/transcytosis in polarized cells.	Iron	76-80	transferrin receptor	Homo sapiens	182-185
16091420-2	2005	Although it has been shown that frataxin is involved in the control of intracellular iron metabolism, by interfering with the mitochondrial biosynthesis of proteins with iron/sulphur (Fe/S) clusters its role has not been well established.	Iron	85-89	frataxin	Homo sapiens	32-40
16091420-2	2005	Although it has been shown that frataxin is involved in the control of intracellular iron metabolism, by interfering with the mitochondrial biosynthesis of proteins with iron/sulphur (Fe/S) clusters its role has not been well established.	Iron	170-174	frataxin	Homo sapiens	32-40
15543932-5	2004	Cellular iron content increased beyond 4 days of exposure to iron at 20 microg/ml, when IRP binding, TfR, and ferritin had all reached stable levels.	Iron	61-65	transferrin receptor	Homo sapiens	101-104
15543932-7	2004	These results indicate that iron-replete HepG2 cells exhibit a narrow range of maximal responsiveness of the IRP-regulatory mechanism, whose functional response is blunted both by excessive iron exposure and by removal of iron from a chelatable pool.	Iron	28-32	Wnt family member 2	Homo sapiens	109-112
16091420-9	2005	Based on our data, we postulate that frataxin could be involved in the biosynthesis of iron-sulphur proteins not only within the mitochondria, but also in the extramitochondrial compartment.	Iron	87-91	frataxin	Homo sapiens	37-45
15543932-7	2004	These results indicate that iron-replete HepG2 cells exhibit a narrow range of maximal responsiveness of the IRP-regulatory mechanism, whose functional response is blunted both by excessive iron exposure and by removal of iron from a chelatable pool.	Iron	190-194	Wnt family member 2	Homo sapiens	109-112
18420243-1	2008	Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier.	Iron	84-86	transferrin receptor	Rattus norvegicus	266-269
15543932-7	2004	These results indicate that iron-replete HepG2 cells exhibit a narrow range of maximal responsiveness of the IRP-regulatory mechanism, whose functional response is blunted both by excessive iron exposure and by removal of iron from a chelatable pool.	Iron	190-194	Wnt family member 2	Homo sapiens	109-112
18420243-7	2008	These results suggest that early events in the tissue response to Mn or Fe exposure involve microtubule-dependent, intracellular trafficking of MTP1 and TfR.	Iron	72-74	transferrin receptor	Rattus norvegicus	153-156
18197362-2	2008	In order to search for helpful information for understanding the behavior of trace iron element in bones and teeth, very small amounts of iron containing HAp(FeHAp) were synthesized from a modified pseudo-body solution at low temperature.	Iron	138-142	reticulon 3	Homo sapiens	154-157
15358563-2	2004	Here, we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 (TfR1) mRNA level in placenta, as shown by cDNA microarray analysis and quantitative RT-PCR, by a mechanism which is independent of placenta iron content and iron responsive element/iron regulatory protein (IRE/IRP) activity.	Iron	235-239	transferrin receptor	Homo sapiens	95-99
15358563-2	2004	Here, we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 (TfR1) mRNA level in placenta, as shown by cDNA microarray analysis and quantitative RT-PCR, by a mechanism which is independent of placenta iron content and iron responsive element/iron regulatory protein (IRE/IRP) activity.	Iron	252-256	transferrin receptor	Homo sapiens	95-99
15358563-2	2004	Here, we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 (TfR1) mRNA level in placenta, as shown by cDNA microarray analysis and quantitative RT-PCR, by a mechanism which is independent of placenta iron content and iron responsive element/iron regulatory protein (IRE/IRP) activity.	Iron	252-256	transferrin receptor	Homo sapiens	95-99
15358563-3	2004	On the contrary, iron injections into pregnant mothers result in increased placenta iron and ferritin content, and reduced IRE binding activity of IRP1 leading to decreased TfR1 mRNA level.	Iron	17-21	aconitase 1	Homo sapiens	147-151
15358563-3	2004	On the contrary, iron injections into pregnant mothers result in increased placenta iron and ferritin content, and reduced IRE binding activity of IRP1 leading to decreased TfR1 mRNA level.	Iron	17-21	transferrin receptor	Homo sapiens	173-177
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	145-149	ferric reduction oxidase 2	Arabidopsis thaliana	61-67
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	264-268	ferric reduction oxidase 2	Arabidopsis thaliana	61-67
16006655-5	2005	AtFRO2 displayed the highest iron reduction activity among the AtFROs investigated, further demonstrating that AtFRO2 is a major iron reductase gene in Arabidopsis.	Iron	29-33	ferric reduction oxidase 2	Arabidopsis thaliana	0-6
16006655-5	2005	AtFRO2 displayed the highest iron reduction activity among the AtFROs investigated, further demonstrating that AtFRO2 is a major iron reductase gene in Arabidopsis.	Iron	29-33	ferric reduction oxidase 2	Arabidopsis thaliana	111-117
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	159-163	ferric reduction oxidase 2	Arabidopsis thaliana	84-90
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	270-274	ferric reduction oxidase 2	Arabidopsis thaliana	84-90
15985433-0	2005	Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.	Iron	56-60	von Hippel-Lindau tumor suppressor	Homo sapiens	12-46
15315790-0	2004	Molecular analysis of iron overload in beta2-microglobulin-deficient mice.	Iron	22-26	beta-2 microglobulin	Mus musculus	39-58
15315790-1	2004	Beta2-microglobulin knockout (beta2m-/-) mice represent an instructive model of spontaneous iron overload resembling genetic hemochromatosis.	Iron	92-96	beta-2 microglobulin	Mus musculus	0-19
15315790-1	2004	Beta2-microglobulin knockout (beta2m-/-) mice represent an instructive model of spontaneous iron overload resembling genetic hemochromatosis.	Iron	92-96	beta-2 microglobulin	Mus musculus	30-40
18197362-6	2008	Compared with the pure HAp material, the prepared iron containing materials showed obviously photo-absorption property in the UV light region.	Iron	50-54	reticulon 3	Homo sapiens	23-26
15951442-2	2005	Because BCMO1 activity is iron-dependent, we propose that these residues participate in iron coordination and therefore are essential for catalytic activity.	Iron	26-30	beta-carotene oxygenase 1	Mus musculus	8-13
15951442-2	2005	Because BCMO1 activity is iron-dependent, we propose that these residues participate in iron coordination and therefore are essential for catalytic activity.	Iron	88-92	beta-carotene oxygenase 1	Mus musculus	8-13
18397377-3	2008	In Arabidopsis, expression of IRT1 and FRO2 is tightly controlled to maintain iron homeostasis, and involves local and long-distance signals, as well as transcriptional and post-transcriptional events.	Iron	78-82	ferric reduction oxidase 2	Arabidopsis thaliana	39-43
15324319-0	2004	A previously undescribed frameshift deletion mutation of HFE (c.del277; G93fs) associated with hemochromatosis and iron overload in a C282Y heterozygote.	Iron	115-119	homeostatic iron regulator	Homo sapiens	57-60
15315822-1	2004	Ferritin has been shown as being the principal iron storage in the majority of living organisms.	Iron	47-51	soma ferritin-like	Crassostrea gigas	0-8
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	12-16	ferric reduction oxidase 2	Arabidopsis thaliana	176-180
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	ferric reduction oxidase 2	Arabidopsis thaliana	176-180
15315826-8	2004	Among these, the Cytochrome c oxidase (COX) subunit II mitochondrial gene resulted to be regulated by both metals, the Serum and Glucocorticoids-regulated Kinase (SGK) gene mainly by iron, and an Ebnerin-like 2 kb mRNA dramatically down-regulated by copper.	Iron	183-187	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	119-161
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	ferric reduction oxidase 2	Arabidopsis thaliana	176-180
15315826-8	2004	Among these, the Cytochrome c oxidase (COX) subunit II mitochondrial gene resulted to be regulated by both metals, the Serum and Glucocorticoids-regulated Kinase (SGK) gene mainly by iron, and an Ebnerin-like 2 kb mRNA dramatically down-regulated by copper.	Iron	183-187	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	163-166
18327971-5	2008	This review highlights the molecular mechanisms responsible for regulation of iron absorption, transport, and storage through the roles of key regulatory proteins, including ferroportin, hepcidin, ferritin, and frataxin.	Iron	78-82	frataxin	Homo sapiens	211-219
18211957-1	2008	Friedreich ataxia, the most common inherited ataxia, is caused by the transcriptional silencing of the FXN gene, which codes for the 210 amino acid frataxin, a mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	194-198	frataxin	Homo sapiens	103-106
15478799-10	2004	In contrast to its human orthologue (AK3), PfGAK contains a zinc finger motif and binds ionic iron.	Iron	94-98	adenylate kinase 3	Homo sapiens	37-40
18211957-1	2008	Friedreich ataxia, the most common inherited ataxia, is caused by the transcriptional silencing of the FXN gene, which codes for the 210 amino acid frataxin, a mitochondrial protein involved in iron-sulfur cluster biosynthesis.	Iron	194-198	frataxin	Homo sapiens	148-156
18408021-4	2008	Transferrin receptor (TfR) is the major mediator of iron uptake.	Iron	52-56	transferrin receptor	Homo sapiens	0-20
15211518-2	2004	Adrenodoxin reductase homologue (Arh1) and yeast adrenodoxin homologue (Yah1) are essential Saccharomyces cerevisiae mitochondrial proteins involved in heme A biosynthesis and in iron-sulfur cluster (FeSC) assembly.	Iron	179-183	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	33-37
18408021-4	2008	Transferrin receptor (TfR) is the major mediator of iron uptake.	Iron	52-56	transferrin receptor	Homo sapiens	22-25
18408021-14	2008	CONCLUSIONS: Iron overload and upregulation of iron-handling proteins, such as TfR, in the MS brain can contribute to pathogenesis of Multiple Sclerosis and iron imbalance is associated with a pro-oxidative stress and a proinflammatory environment, this suggest that iron could be a target for MS therapy to improve neuronal iron metabolism.	Iron	47-51	transferrin receptor	Homo sapiens	79-82
15231391-3	2004	This transcytosis is transferrin receptor (TfR)-mediated with use of a bifunctional adaptor, soluble coxsackie adenovirus receptor (sCAR)-Tf, and is both temperature and iron dependent.	Iron	170-174	transferrin receptor	Homo sapiens	21-41
15231391-3	2004	This transcytosis is transferrin receptor (TfR)-mediated with use of a bifunctional adaptor, soluble coxsackie adenovirus receptor (sCAR)-Tf, and is both temperature and iron dependent.	Iron	170-174	transferrin receptor	Homo sapiens	43-46
18451267-5	2008	The mask phenotype results from reduced absorption of dietary iron caused by high levels of hepcidin and is due to a splicing defect in the transmembrane serine protease 6 gene Tmprss6.	Iron	62-66	transmembrane serine protease 6	Mus musculus	177-184
21825741-3	2008	The growth direction of SnO(2) nanorods is [001], significantly affected by that of alpha-Fe(2)O(3) nanorods.	Iron	89-92	strawberry notch homolog 1	Homo sapiens	24-27
18546721-13	2008	Total AH-receptor (AHR) agonist concentrations of diesel exhaust were lowered by 80-90%, when using the iron- and copper-based DPFs.	Iron	104-108	aryl hydrocarbon receptor	Homo sapiens	6-17
15529941-8	2004	Patients with evidence of iron overload, a family history of HH or other risk factors should be screened by genotype testing for the HFE mutation.	Iron	26-30	homeostatic iron regulator	Homo sapiens	133-136
15212743-7	2004	Indiscriminate iron supplementation carries the risk of inducing hemochromatosis in individuals homozygous for the widespread C282Y allele of the HFE gene.	Iron	15-19	homeostatic iron regulator	Homo sapiens	146-149
18546721-13	2008	Total AH-receptor (AHR) agonist concentrations of diesel exhaust were lowered by 80-90%, when using the iron- and copper-based DPFs.	Iron	104-108	aryl hydrocarbon receptor	Homo sapiens	19-22
18042412-7	2008	These findings may have implications for HFE-testing of iron overloaded heterozygous Cys282Tyr-patients of Northern European origin and their relatives.	Iron	56-60	homeostatic iron regulator	Homo sapiens	41-44
15123683-0	2004	Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis.	Iron	18-22	frataxin	Homo sapiens	0-8
15123683-4	2004	A general regulatory mechanism for mitochondrial iron metabolism is described that defines frataxin involvement in both heme and iron-sulfur cluster biosyntheses.	Iron	49-53	frataxin	Homo sapiens	91-99
15123683-4	2004	A general regulatory mechanism for mitochondrial iron metabolism is described that defines frataxin involvement in both heme and iron-sulfur cluster biosyntheses.	Iron	129-133	frataxin	Homo sapiens	91-99
18280258-0	2008	Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins.	Iron	17-21	frataxin	Homo sapiens	58-66
15123683-5	2004	In essence, the distinct binding affinities of holofrataxin to the target proteins, ferrochelatase (heme synthesis) and ISU (iron-sulfur cluster synthesis), allows discrimination between the two major iron-dependent pathways and facilitates targeted heme biosynthesis following down-regulation of frataxin.	Iron	125-129	frataxin	Homo sapiens	51-59
15123683-5	2004	In essence, the distinct binding affinities of holofrataxin to the target proteins, ferrochelatase (heme synthesis) and ISU (iron-sulfur cluster synthesis), allows discrimination between the two major iron-dependent pathways and facilitates targeted heme biosynthesis following down-regulation of frataxin.	Iron	201-205	frataxin	Homo sapiens	51-59
15044462-0	2004	Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells.	Iron	97-101	homeostatic iron regulator	Homo sapiens	53-56
18367482-0	2008	Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.	Iron	88-92	eukaryotic translation initiation factor 2A	Mus musculus	29-38
15044462-7	2004	These results point to a role for HFE in inhibition of iron efflux in HT29 cells.	Iron	55-59	homeostatic iron regulator	Homo sapiens	34-37
15044462-8	2004	This is a distinct role from that in HeLa and human embryonic kidney 293 cells where HFE has been shown to inhibit TF-mediated iron uptake resulting in decreased ferritin levels.	Iron	127-131	homeostatic iron regulator	Homo sapiens	85-88
15044462-9	2004	Such a distinction suggests a multifunctional role for HFE that is dependent upon expression levels of proteins involved in iron transport.	Iron	124-128	homeostatic iron regulator	Homo sapiens	55-58
18482685-9	2008	Autoradiographic analyses revealed a good correlation between dopamine transporter (DAT)-rich regions and the uptake pattern of FE@CIT.	Iron	128-130	solute carrier family 6 member 3	Rattus norvegicus	84-87
15135642-0	2004	Mutational biases associated with potential iron-binding DNA motifs in rodent lacI and human p53 mutational databases.	Iron	44-48	tissue factor pathway inhibitor	Homo sapiens	78-82
18281282-0	2008	Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.	Iron	74-78	aminopeptidase P	Saccharomyces cerevisiae S288C	18-22
18281282-0	2008	Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.	Iron	126-130	aminopeptidase P	Saccharomyces cerevisiae S288C	18-22
18281282-2	2008	Using a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a complex that interprets the signal derived from mitochondrial Fe-S synthesis.	Iron	164-168	aminopeptidase P	Saccharomyces cerevisiae S288C	68-72
14992688-1	2004	Ftr1p is the permease component of the Fet3p-Ftr1p high affinity iron-uptake complex, in the plasma membrane of Saccharomyces cerevisiae, that transports the Fe3+ produced by the Fet3p ferroxidase into the cell.	Iron	65-69	ferroxidase FET3	Saccharomyces cerevisiae S288C	39-44
18281282-3	2008	We found that mutations in FRA1 (YLL029W) and FRA2 (YGL220W) led to an increase in transcription of the iron regulon.	Iron	104-108	aminopeptidase P	Saccharomyces cerevisiae S288C	27-31
14992688-1	2004	Ftr1p is the permease component of the Fet3p-Ftr1p high affinity iron-uptake complex, in the plasma membrane of Saccharomyces cerevisiae, that transports the Fe3+ produced by the Fet3p ferroxidase into the cell.	Iron	65-69	ferroxidase FET3	Saccharomyces cerevisiae S288C	179-184
18281282-7	2008	We show that Fra1 and Fra2 interact in the cytosol in an iron-independent fashion.	Iron	57-61	aminopeptidase P	Saccharomyces cerevisiae S288C	13-17
14992688-12	2004	Ile369 was the only residue identified in this domain that made such a major contribution to iron uptake by the Fet3p-Ftr1p complex.	Iron	93-97	ferroxidase FET3	Saccharomyces cerevisiae S288C	112-117
18281282-8	2008	The Fra1-Fra2 complex binds to Grx3 and Grx4, two cytosolic monothiol glutaredoxins, in an iron-independent fashion.	Iron	91-95	aminopeptidase P	Saccharomyces cerevisiae S288C	4-8
18287331-0	2008	Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.	Iron	65-69	bone morphogenetic protein 2	Homo sapiens	85-90
15215598-1	2004	Phosvitin, a phosphoprotein known as an iron-carrier in egg yolk, binds almost all the yolk iron.	Iron	40-44	casein kinase 2 beta	Homo sapiens	0-9
15215598-1	2004	Phosvitin, a phosphoprotein known as an iron-carrier in egg yolk, binds almost all the yolk iron.	Iron	92-96	casein kinase 2 beta	Homo sapiens	0-9
15215598-3	2004	Using electron spin resonance (ESR) with 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and deoxyribose degradation assays, we observed by both assays that phosvitin more effectively inhibited (.-)OH formation than iron-binding proteins such as ferritin and transferrin.	Iron	208-212	casein kinase 2 beta	Homo sapiens	149-158
15215598-4	2004	The effectiveness of phosvitin was related to the iron concentration, indicating that phosvitin acts as an antioxidant by chelating iron ions.	Iron	50-54	casein kinase 2 beta	Homo sapiens	21-30
18155133-9	2008	The presence of VSOP-labelled hMSCs was indicated by distinct hypointense spots in the MR images, as a result of iron specific loss of signal intensity.	Iron	113-117	hydrogen voltage gated channel 1	Homo sapiens	16-20
15163319-7	2004	We evaluated the possible causes of elevated TfR concentrations in patients having stainable iron in the bone marrow, and this study suggests that functional iron deficiency explains a considerable proportion of these cases.	Iron	93-97	transferrin receptor	Homo sapiens	45-48
18297188-3	2008	In eukaryotes, iron-regulatory protein 1 (IRP1) plays a central role in the control of intracellular iron homeostasis.	Iron	15-19	aconitase 1	Homo sapiens	42-46
15120309-3	2004	It was shown that the BET surface area of Na-clay was similar to that of Fe-clay, but somewhat different from those of Cr- and Ti-clay; it decreased in the order Na- &gt; Fe- &gt; Ti- &gt; Cr-montmorillonite.	Iron	73-75	delta/notch like EGF repeat containing	Homo sapiens	22-25
15147898-4	2004	A complementation assay demonstrated that the protein encoded by this cDNA could functionally replace Ccc2p, a Saccharomyces cerevisiae Cu(2+)-ATPase, rescuing growth of ccc2 mutant under iron-limited conditions.	Iron	188-192	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	102-107
16039939-6	2005	The increased activity of iron-regulatory protein 1 after nickel exposure stabilized and increased transferrin receptor (Tfr) mRNA and antagonized the iron-induced ferritin light chain protein synthesis.	Iron	26-30	transferrin receptor	Homo sapiens	99-119
16039939-6	2005	The increased activity of iron-regulatory protein 1 after nickel exposure stabilized and increased transferrin receptor (Tfr) mRNA and antagonized the iron-induced ferritin light chain protein synthesis.	Iron	26-30	transferrin receptor	Homo sapiens	121-124
16039939-9	2005	Iron treatment reversed the effect of nickel on cytosolic aconitase and iron-regulatory protein 1.	Iron	0-4	aconitase 1	Homo sapiens	72-97
15147898-4	2004	A complementation assay demonstrated that the protein encoded by this cDNA could functionally replace Ccc2p, a Saccharomyces cerevisiae Cu(2+)-ATPase, rescuing growth of ccc2 mutant under iron-limited conditions.	Iron	188-192	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	170-174
18297188-4	2008	This occurs by interaction of IRP1 with iron-responsive element regions at 5" of ferritin mRNA and 3" of transferrin mRNA which, respectively, represses translation and increases mRNA stability.	Iron	40-44	aconitase 1	Homo sapiens	30-34
18396134-2	2008	Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.	Iron	135-139	homeostatic iron regulator	Homo sapiens	192-195
15136693-1	2004	The presence of oxidative damage and increased iron deposition in CNS tissues of ALS patients prompted the authors to examine the prevalence of two common HFE gene mutations linked to iron accumulation and consequent oxidative stress.	Iron	47-51	homeostatic iron regulator	Homo sapiens	155-158
15136693-1	2004	The presence of oxidative damage and increased iron deposition in CNS tissues of ALS patients prompted the authors to examine the prevalence of two common HFE gene mutations linked to iron accumulation and consequent oxidative stress.	Iron	184-188	homeostatic iron regulator	Homo sapiens	155-158
16196791-1	2005	In situ x-ray diffraction studies of iron under shock conditions confirm unambiguously a phase change from the bcc (alpha) to hcp (epsilon) structure.	Iron	37-41	alpha-1-microglobulin/bikunin precursor	Homo sapiens	126-129
18266949-6	2008	For example, although the ion channel DMT1 (now formally known as slc11a2) is essential for iron uptake in the gut, knockout mice, which have no slc11a2 protein, have apparently normal transfer across the placenta.	Iron	92-96	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	38-42
16043695-0	2005	HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.	Iron	80-84	homeostatic iron regulator	Homo sapiens	53-56
16043695-3	2005	We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeostasis and is mutated in the iron-overloading disorder hemochromatosis.	Iron	99-103	homeostatic iron regulator	Homo sapiens	78-81
16043695-3	2005	We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeostasis and is mutated in the iron-overloading disorder hemochromatosis.	Iron	138-142	homeostatic iron regulator	Homo sapiens	78-81
16043695-8	2005	The iron accumulation in HIV-1-infected HFE-expressing macrophages was paralleled by an increase in cellular HIV-1-gag expression.	Iron	4-8	homeostatic iron regulator	Homo sapiens	40-43
16043695-9	2005	We conclude that, through Nef and HFE, HIV-1 directly regulates cellular iron metabolism, possibly benefiting viral growth.	Iron	73-77	homeostatic iron regulator	Homo sapiens	34-37
15840699-1	2005	HFE is a protein known to be involved in iron metabolism; yet, other than its homology with major histocompatibility complex (MHC) class I molecules, it has not been described as having an immunologic function.	Iron	41-45	homeostatic iron regulator	Homo sapiens	0-3
14993228-3	2004	The list includes several key genes in copper and iron homeostasis, such as CCC2, RCS1, FET3, LYS7, and CTR1.	Iron	50-54	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	76-80
14993228-3	2004	The list includes several key genes in copper and iron homeostasis, such as CCC2, RCS1, FET3, LYS7, and CTR1.	Iron	50-54	ferroxidase FET3	Saccharomyces cerevisiae S288C	88-92
14993228-3	2004	The list includes several key genes in copper and iron homeostasis, such as CCC2, RCS1, FET3, LYS7, and CTR1.	Iron	50-54	copper chaperone CCS1	Saccharomyces cerevisiae S288C	94-98
14993228-9	2004	Supplementation with iron improved somewhat the tolerance of a fet3 strain but was ineffective in a ctr1 mutant, suggesting the existence of additional copper-requiring functions important for tolerance to an alkaline environment.	Iron	21-25	ferroxidase FET3	Saccharomyces cerevisiae S288C	63-67
18266949-6	2008	For example, although the ion channel DMT1 (now formally known as slc11a2) is essential for iron uptake in the gut, knockout mice, which have no slc11a2 protein, have apparently normal transfer across the placenta.	Iron	92-96	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	66-73
15110995-3	2004	IRP1 is regulated by such factors as intracellular iron levels, the oxidants H(2)O(2) and NO.	Iron	51-55	aconitase 1	Homo sapiens	0-4
18403237-2	2008	Several ExPEC virulence genes have already been described such as iutA involved in iron acquisition and ibeA required for invasion of eukaryotic cells.	Iron	83-87	Aerobactin siderophore ferric receptor protein IutA	Escherichia coli	66-70
15159209-0	2004	Inhibition of Ape1 nuclease activity by lead, iron, and cadmium.	Iron	46-50	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	14-18
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	33-37	homeostatic iron regulator	Homo sapiens	115-118
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	homeostatic iron regulator	Homo sapiens	115-118
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	homeostatic iron regulator	Homo sapiens	115-118
16117851-0	2005	AtbHLH29 of Arabidopsis thaliana is a functional ortholog of tomato FER involved in controlling iron acquisition in strategy I plants.	Iron	96-100	bHLH transcriptional regulator	Solanum lycopersicum	68-71
16117851-1	2005	AtbHLH29 of Arabidopsis, encoding a bHLH protein, reveals a high similarity to the tomato FER which is proposed as a transcriptional regulator involved in controlling the iron deficiency responses and the iron uptake in tomato.	Iron	171-175	bHLH transcriptional regulator	Solanum lycopersicum	90-93
16117851-6	2005	Our transformation data demonstrate that AtbHLH29 is a functional ortholog of the tomato FER and can completely replace FER in controlling the effective iron acquisition in tomato.	Iron	153-157	bHLH transcriptional regulator	Solanum lycopersicum	89-92
16117851-6	2005	Our transformation data demonstrate that AtbHLH29 is a functional ortholog of the tomato FER and can completely replace FER in controlling the effective iron acquisition in tomato.	Iron	153-157	bHLH transcriptional regulator	Solanum lycopersicum	120-123
16117851-8	2005	Identification of the similar biological functions of FER and AtbHLH29, which isolated from two systematically wide-diverged "strategy I" plants, suggests that FER might be a universal gene presented in all strategy I plants in controlling effective iron acquisition system in roots.	Iron	250-254	bHLH transcriptional regulator	Solanum lycopersicum	54-57
15093745-4	2004	As anticipated, several genes involved in glucose and iron metabolism and neovascularization were upregulated, the latter group we here show to include the gene encoding chromogranin C and its cleavage product, secretoneurin, a vascular smooth muscle cell mitogen.	Iron	54-58	secretogranin II	Homo sapiens	170-184
15093745-4	2004	As anticipated, several genes involved in glucose and iron metabolism and neovascularization were upregulated, the latter group we here show to include the gene encoding chromogranin C and its cleavage product, secretoneurin, a vascular smooth muscle cell mitogen.	Iron	54-58	secretogranin II	Homo sapiens	211-224
18221364-0	2008	A proteomic study showing differential regulation of stress, redox regulation and peroxidase proteins by iron supply and the transcription factor FER.	Iron	105-109	peroxidase	Solanum lycopersicum	82-92
15334819-1	2004	Biosynthesis of ceruloplasmin, a copper-containing glycoprotein, which plays an important role in copper transfer and bidirectional iron transport in vertebrates, was studied in 7-day old rats characterized by the embryonic type of copper metabolism.	Iron	132-136	ceruloplasmin	Rattus norvegicus	16-29
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	125-129	aconitase 1	Homo sapiens	0-25
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	125-129	aconitase 1	Homo sapiens	27-31
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	125-129	transferrin receptor	Homo sapiens	192-212
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	125-129	transferrin receptor	Homo sapiens	214-217
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	230-234	aconitase 1	Homo sapiens	0-25
14742448-0	2004	Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide.	Iron	137-141	transferrin receptor	Homo sapiens	116-136
14742448-5	2004	Pretreatment with cell-permeable iron chelators, TfR antibody (that inhibits TfR-mediated iron uptake), or transfection with glutathione peroxidase (GPx1) enzyme inhibits intracellular oxidant generation, alpha-syn expression/aggregation, and apoptotic signaling as measured by caspase-3 activation.	Iron	90-94	transferrin receptor	Homo sapiens	77-80
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	230-234	aconitase 1	Homo sapiens	27-31
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	230-234	transferrin receptor	Homo sapiens	192-212
18221364-1	2008	Plants need to mobilize iron in the soil, and the basic helix-loop-helix transcription factor FER is a central regulator of iron acquisition in tomato roots.	Iron	24-28	bHLH transcriptional regulator	Solanum lycopersicum	94-97
16036361-1	2005	Iron regulatory protein 1 (IRP1) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor (TfR)--the major iron uptake protein.	Iron	230-234	transferrin receptor	Homo sapiens	214-217
16036361-3	2005	While H2O2--similar to iron depletion--strongly induces IRP1 via a signalling cascade, O2*- inactivates the mRNA binding activity by a direct chemical attack.	Iron	23-27	aconitase 1	Homo sapiens	56-60
18221364-1	2008	Plants need to mobilize iron in the soil, and the basic helix-loop-helix transcription factor FER is a central regulator of iron acquisition in tomato roots.	Iron	124-128	bHLH transcriptional regulator	Solanum lycopersicum	94-97
14656877-6	2004	These results suggest that other beta2m-interacting protein(s) may be involved in iron regulation and that in the absence of functional Hfe molecules lymphocyte numbers may influence iron overload severity.	Iron	82-86	beta-2 microglobulin	Mus musculus	33-39
18221364-2	2008	FER activity is controlled by iron supply.	Iron	30-34	bHLH transcriptional regulator	Solanum lycopersicum	0-3
16083706-11	2005	Early diagnosis of hepatic iron overload using HFE gene testing and iron depletion prior to liver transplantation may improve posttransplantation survival, particularly among patients with HH.	Iron	27-31	homeostatic iron regulator	Homo sapiens	47-50
18221364-8	2008	We investigated the functional representation in the identified expression clusters, and found that loss of FER function in iron-cultured plants mimicked an iron-deficiency status.	Iron	124-128	bHLH transcriptional regulator	Solanum lycopersicum	108-111
14670915-10	2004	Based on a digenic model of inheritance, these data suggest that the association of heterozygous mutations in the HFE and HAMP genes could lead, at least in some cases, to an adult-onset form of primary iron overload.	Iron	203-207	homeostatic iron regulator	Homo sapiens	114-117
15744747-0	2005	Effects of development and iron status on ceruloplasmin expression in rat brain.	Iron	27-31	ceruloplasmin	Rattus norvegicus	42-55
18302323-8	2008	Low-temperature resonance Raman spectra of the beta1(1-194)-NO and beta2(1-217)-NO complexes show that the Fe-NO stretching vibration of the beta2(1-217)-NO complex (535 cm (-1)) is significantly different from that of the beta1(1-194)-NO complex (527 cm (-1)).	Iron	107-109	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	67-82
15744747-1	2005	The increased iron content in the brain of subjects with aceruloplasminemia has implicated ceruloplasmin (CP) as a major factor in the regulation of regional brain iron content.	Iron	14-18	ceruloplasmin	Rattus norvegicus	58-71
15744747-1	2005	The increased iron content in the brain of subjects with aceruloplasminemia has implicated ceruloplasmin (CP) as a major factor in the regulation of regional brain iron content.	Iron	164-168	ceruloplasmin	Rattus norvegicus	106-108
15744747-2	2005	In this study, we investigated the effects of age and iron on CP expression in rat brain.	Iron	54-58	ceruloplasmin	Rattus norvegicus	62-64
15744747-9	2005	These findings suggested that the effects of iron on CP expression in the brain may be region-specific, and that regulation of CP expression by iron in the substantia nigra was at the post-transcriptional level.	Iron	144-148	ceruloplasmin	Rattus norvegicus	127-129
16024809-7	2005	Computer analysis found different cis-regulatory elements for Aft1 and Aft2, and transcription analysis using variants of the FET3 promoter indicated that Aft1 is more specific for the canonical iron-responsive element TGCACCC than is Aft2.	Iron	195-199	ferroxidase FET3	Saccharomyces cerevisiae S288C	126-130
15015967-1	2004	Transferrin receptor 1 (TfR1) is a type II membrane protein that mediates cellular iron uptake.	Iron	83-87	transferrin receptor	Homo sapiens	0-22
15015967-1	2004	Transferrin receptor 1 (TfR1) is a type II membrane protein that mediates cellular iron uptake.	Iron	83-87	transferrin receptor	Homo sapiens	24-28
15075083-1	2004	In this study, we evaluated the impact of mutations of the HFE and ferroportin gene on iron overload in thalassemia intermedia and betas/betathal patients.	Iron	87-91	homeostatic iron regulator	Homo sapiens	59-62
15927492-2	2005	We have tested the hypothesis that chronic iron overload (CIO) enhances inducible nitric oxide synthase (iNOS) expression in rat liver by extracellular signal-regulated kinase (ERK1/2) and NF-kappaB activation.	Iron	43-47	mitogen activated protein kinase 3	Rattus norvegicus	177-183
18302323-8	2008	Low-temperature resonance Raman spectra of the beta1(1-194)-NO and beta2(1-217)-NO complexes show that the Fe-NO stretching vibration of the beta2(1-217)-NO complex (535 cm (-1)) is significantly different from that of the beta1(1-194)-NO complex (527 cm (-1)).	Iron	107-109	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	141-156
18245813-7	2008	Iron depletion of Sprague-Dawley rats increased HIF-1alpha expression, improved glucose clearance, and was associated with up-regulation of insulin receptor and Akt/PKB levels and of glucose transport in hepatic tissue.	Iron	0-4	insulin receptor	Rattus norvegicus	140-156
18245813-10	2008	Thus, iron depletion by deferoxamine up-regulates glucose uptake, and increases insulin receptor activity and signaling in hepatocytes in vitro and in vivo.	Iron	6-10	insulin receptor	Rattus norvegicus	80-96
15024747-5	2004	The investigated patient was also found to harbor a heterozygous HFE c.845G&gt;A (p.C282Y) mutation that may have contributed in increasing his iron burden.	Iron	144-148	homeostatic iron regulator	Homo sapiens	65-68
18488871-6	2008	In hereditary and juvenile types of hemochromatosis, iron overload could be partially due to the down-regulation of hepcidin by the mutated genes HFE and HJV.	Iron	53-57	homeostatic iron regulator	Homo sapiens	146-149
15039307-1	2004	Metal-dependent transcriptional regulators of the diphtheria toxin repressor (DtxR) family have been identified in a wide variety of bacterial genera, where they control gene expression in response to one of two metal ions, Fe(2+) or Mn(2+).	Iron	224-226	MarR family transcriptional regulator	Corynebacterium diphtheriae	50-76
15039307-1	2004	Metal-dependent transcriptional regulators of the diphtheria toxin repressor (DtxR) family have been identified in a wide variety of bacterial genera, where they control gene expression in response to one of two metal ions, Fe(2+) or Mn(2+).	Iron	224-226	MarR family transcriptional regulator	Corynebacterium diphtheriae	78-82
15039307-8	2004	The high level of identity at both DNA and protein levels suggests that all of the isolates tested encode a functional DtxR-like Fe(2+)-activated regulatory protein that can bind homologs of the DtxR operator and regulate gene expression in response to iron.	Iron	253-257	MarR family transcriptional regulator	Corynebacterium diphtheriae	119-123
15039307-8	2004	The high level of identity at both DNA and protein levels suggests that all of the isolates tested encode a functional DtxR-like Fe(2+)-activated regulatory protein that can bind homologs of the DtxR operator and regulate gene expression in response to iron.	Iron	253-257	MarR family transcriptional regulator	Corynebacterium diphtheriae	195-199
15946650-1	2005	High affinity iron uptake in yeast is carried out by a multicomponent system formed by the ferroxidase Fet3p and the iron permease Ftr1p.	Iron	14-18	ferroxidase FET3	Saccharomyces cerevisiae S288C	91-108
16042809-9	2005	CONCLUSION: We conclude that there is a significant inverse relationship of total blood lymphocyte counts and severity of iron overload in hemochromatosis probands with HFE C282Y homozygosity.	Iron	122-126	homeostatic iron regulator	Homo sapiens	169-172
18336670-3	2008	Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the increased expression of transferrin receptor (TfR) 1; and increased intestinal iron absorption by the lowering of hepcidin.	Iron	28-32	transferrin receptor	Homo sapiens	139-159
15970401-1	2005	In low-iron conditions, the cytosolic iron-regulatory protein IRP1 binds to iron-responsive elements (IREs) in mRNAs encoding iron-regulated proteins.	Iron	7-11	aconitase 1	Homo sapiens	62-66
15970401-1	2005	In low-iron conditions, the cytosolic iron-regulatory protein IRP1 binds to iron-responsive elements (IREs) in mRNAs encoding iron-regulated proteins.	Iron	38-42	aconitase 1	Homo sapiens	62-66
15970401-1	2005	In low-iron conditions, the cytosolic iron-regulatory protein IRP1 binds to iron-responsive elements (IREs) in mRNAs encoding iron-regulated proteins.	Iron	38-42	aconitase 1	Homo sapiens	62-66
15970401-1	2005	In low-iron conditions, the cytosolic iron-regulatory protein IRP1 binds to iron-responsive elements (IREs) in mRNAs encoding iron-regulated proteins.	Iron	38-42	aconitase 1	Homo sapiens	62-66
15970401-2	2005	In high-iron conditions, IRP1 incorporates an iron-sulfur cluster (ISC), which interferes with IRE binding and prevents intracellular iron accumulation.	Iron	8-12	aconitase 1	Homo sapiens	25-29
15970401-2	2005	In high-iron conditions, IRP1 incorporates an iron-sulfur cluster (ISC), which interferes with IRE binding and prevents intracellular iron accumulation.	Iron	46-50	aconitase 1	Homo sapiens	25-29
15970401-2	2005	In high-iron conditions, IRP1 incorporates an iron-sulfur cluster (ISC), which interferes with IRE binding and prevents intracellular iron accumulation.	Iron	46-50	aconitase 1	Homo sapiens	25-29
15970401-4	2005	Our data suggest an impaired adaptive response to iron accumulation in FRDA cells.	Iron	50-54	frataxin	Homo sapiens	71-75
14640978-4	2004	When examined using calcein fluorescence or radioactive iron, DAG (diacylglycerol)-stimulated NTBI entry was more in NGF-treated PC12 cells compared with untreated cells.	Iron	56-60	nerve growth factor	Rattus norvegicus	117-120
18336670-3	2008	Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the increased expression of transferrin receptor (TfR) 1; and increased intestinal iron absorption by the lowering of hepcidin.	Iron	28-32	transferrin receptor	Homo sapiens	161-164
18336670-3	2008	Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the increased expression of transferrin receptor (TfR) 1; and increased intestinal iron absorption by the lowering of hepcidin.	Iron	60-64	transferrin receptor	Homo sapiens	139-159
14672930-2	2004	The Saccharomyces cerevisiae SDH is composed of a catalytic dimer of the Sdh1p and Sdh2p subunits containing flavin adenine dinucleotide (FAD) and iron-sulfur clusters and a heme b-containing membrane-anchoring domain comprised of the Sdh3p and Sdh4p subunits.	Iron	147-151	succinate dehydrogenase flavoprotein subunit SDH1	Saccharomyces cerevisiae S288C	73-78
14672930-2	2004	The Saccharomyces cerevisiae SDH is composed of a catalytic dimer of the Sdh1p and Sdh2p subunits containing flavin adenine dinucleotide (FAD) and iron-sulfur clusters and a heme b-containing membrane-anchoring domain comprised of the Sdh3p and Sdh4p subunits.	Iron	147-151	succinate dehydrogenase iron-sulfur protein subunit SDH2	Saccharomyces cerevisiae S288C	83-88
14672935-1	2004	The iron- and manganese-containing superoxide dismutases (Fe/Mn-SOD) share the same chemical function and spatial structure but can be distinguished according to their modes of oligomerization and their metal ion specificity.	Iron	4-8	superoxide dismutase 2	Homo sapiens	61-67
15991291-0	2005	Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan.	Iron	50-54	homeostatic iron regulator	Homo sapiens	14-17
15991291-1	2005	AIM: To assess the prevalence of the two mutations, C282Y and H63D of HFE gene, in healthy subjects, patients with chronic hepatitis C (CHC), and patients with nonalcoholic fatty liver disease (NAFLD) in Taiwan and to explore the contribution of the HFE mutation on serum iron stores in CHC and NAFLD groups.	Iron	272-276	homeostatic iron regulator	Homo sapiens	70-73
18336670-3	2008	Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the increased expression of transferrin receptor (TfR) 1; and increased intestinal iron absorption by the lowering of hepcidin.	Iron	60-64	transferrin receptor	Homo sapiens	161-164
15139495-5	2004	HFE genotyping of 60 subjects with a low initial but normal fasting unbound iron-binding capacity revealed heterozygote H63D in seven (11.6%).	Iron	76-80	homeostatic iron regulator	Homo sapiens	0-3
18336670-3	2008	Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the increased expression of transferrin receptor (TfR) 1; and increased intestinal iron absorption by the lowering of hepcidin.	Iron	60-64	transferrin receptor	Homo sapiens	139-159
15849248-4	2005	In wild-type deoxy myoglobin, the passage between the distal pocket and the solvent is strictly correlated to the presence/absence of a water molecule that simultaneously interacts with the distal histidine side chain and the heme iron; conversely, in the photodissociated myoglobin, the connection with the bulk solvent is always open when CO is in the vicinity of the A pyrrole ring.	Iron	231-235	myoglobin	Physeter catodon	19-28
18336670-3	2008	Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the increased expression of transferrin receptor (TfR) 1; and increased intestinal iron absorption by the lowering of hepcidin.	Iron	60-64	transferrin receptor	Homo sapiens	161-164
18336670-8	2008	In an experimental model, ethanol exposure to the primary cultured-hepatocytes in the presence of iron increased TfR1 expression and (59)Fe-labeled Tf uptake.	Iron	98-102	transferrin receptor	Homo sapiens	113-117
15672419-5	2005	Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate.	Iron	70-74	transferrin receptor	Homo sapiens	138-158
15009675-11	2004	These results demonstrate that both iron accumulation and deprivation modulate the synthesis of ferritin and TfR in astrocytes and that protein synthesis is required to prevent iron-mediated toxicity in astrocytes.	Iron	36-40	transferrin receptor	Rattus norvegicus	109-112
15672419-5	2005	Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate.	Iron	70-74	transferrin receptor	Homo sapiens	160-163
17700530-3	2008	Elevating cellular iron levels in Caco-2 and SW480 cells caused increased Wnt signalling as indicated by increased TOPFLASH reporter activity, increased mRNA expression of two known targets, c-myc and Nkd1, and increased cellular proliferation.	Iron	19-23	NKD inhibitor of WNT signaling pathway 1	Homo sapiens	201-205
15672419-5	2005	Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate.	Iron	186-190	transferrin receptor	Homo sapiens	138-158
15672419-5	2005	Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate.	Iron	186-190	transferrin receptor	Homo sapiens	160-163
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	13-17	transferrin receptor	Homo sapiens	70-92
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	13-17	transferrin receptor	Homo sapiens	94-98
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	19-21	transferrin receptor	Homo sapiens	70-92
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	19-21	transferrin receptor	Homo sapiens	94-98
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	110-112	transferrin receptor	Homo sapiens	70-92
14980214-1	2004	How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells?	Iron	110-112	transferrin receptor	Homo sapiens	94-98
16121509-2	2005	The zero-valent iron shows promising results as a reductant of hexavalent chromium (Cr+6) to trivalent chromium (Cr+3), capable of 100% reduction.	Iron	16-20	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	113-117
14980223-1	2004	Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	182-202
18460494-1	2008	OBJECTIVE: To determine the relative importance of HFE gene, diet, lifestyle, and blood loss characteristics for predicting iron status in a sample of men aged 40 years or over.	Iron	124-128	homeostatic iron regulator	Homo sapiens	51-54
14980223-1	2004	Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	204-207
14980223-6	2004	The structure of TfR-Tf complex helps account for known differences in the iron-release properties of free and receptor bound Tf.	Iron	75-79	transferrin receptor	Homo sapiens	17-20
14643898-1	2004	To secure iron from transferrin, hepatocytes use two pathways, one dependent on transferrin receptor (TfR 1) and the other, of greater capacity but lower affinity, independent of TfR 1.	Iron	10-14	transferrin receptor	Homo sapiens	102-107
14981211-7	2004	Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin).	Iron	23-27	transferrin receptor	Mus musculus	133-153
14981211-7	2004	Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin).	Iron	23-27	transferrin receptor	Mus musculus	155-159
14981211-7	2004	Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin).	Iron	23-27	transferrin receptor	Mus musculus	305-309
16121509-4	2005	Removal of Cr+3 by adsorption or precipitation on iron leads to complete removal of chromium from the waste and was a slower process than the reduction of Cr+6.	Iron	50-54	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	11-15
15679468-0	2005	Molecular characterization of human xanthine oxidoreductase: the enzyme is grossly deficient in molybdenum and substantially deficient in iron-sulphur centres.	Iron	138-142	xanthine dehydrogenase	Homo sapiens	36-59
18226225-7	2008	Moreover, the replacement of domain 4 of IRP1 with the corresponding region of IRP2 sensitized the chimerical IRP11-3/IRP24 protein to iron-dependent degradation, while the reverse manipulation gave rise to a stable chimerical IRP21-3/IRP14 protein.	Iron	135-139	aconitase 1	Homo sapiens	41-45
15925529-4	2005	Both mechanisms are linked to an HFE-related hepatic failure in producing hepcidin, a key hormone of body iron regulation.	Iron	106-110	homeostatic iron regulator	Homo sapiens	33-36
15925529-8	2005	The HFE gene discovery has also paved the road of an enlarged field of differential diagnoses corresponding to novel entities of non-HFE related genetic iron overload syndromes.	Iron	153-157	homeostatic iron regulator	Homo sapiens	4-7
18029358-2	2008	The archaeal Rad3 (xeroderma pigmentosum group D protein (XPD)) helicase is a prototypical member of the Rad3 family, distinct from other related (superfamily II) SF2 enzymes because of a unique insertion containing an iron-sulfur (FeS) cluster.	Iron	232-235	helicase for meiosis 1	Homo sapiens	64-72
15925529-8	2005	The HFE gene discovery has also paved the road of an enlarged field of differential diagnoses corresponding to novel entities of non-HFE related genetic iron overload syndromes.	Iron	153-157	homeostatic iron regulator	Homo sapiens	133-136
14726953-6	2004	Our findings indicate that the small RNA-binding fraction of IRP1, which is insensitive to cellular iron status, contributes to basal mammalian iron homeostasis, whereas IRP2 is sensitive to iron status and can compensate for the loss of IRP1 by increasing its binding activity.	Iron	144-148	aconitase 1	Homo sapiens	61-65
14726953-6	2004	Our findings indicate that the small RNA-binding fraction of IRP1, which is insensitive to cellular iron status, contributes to basal mammalian iron homeostasis, whereas IRP2 is sensitive to iron status and can compensate for the loss of IRP1 by increasing its binding activity.	Iron	144-148	aconitase 1	Homo sapiens	61-65
17938254-0	2008	Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.	Iron	78-82	furin (paired basic amino acid cleaving enzyme)	Mus musculus	0-5
15885606-0	2005	Iron overload in an African American woman with SS hemoglobinopathy and a promoter mutation in the X-linked erythroid-specific 5-aminolevulinate synthase (ALAS2) gene.	Iron	0-4	5'-aminolevulinate synthase 2	Homo sapiens	155-160
15885606-1	2005	We report the case of an African American woman with sickle cell anemia and iron overload incompletely explained by erythrocyte transfusion who is heterozygous for a promoter mutation in the X-linked erythroid-specific 5-aminolevulinate synthase gene (ALAS2): a C to G transversion at nucleotide -206 from the transcription start site, as defined by primer extension (-258 from the start ATG).	Iron	76-80	5'-aminolevulinate synthase 2	Homo sapiens	252-257
15885606-6	2005	We conclude that an ALAS2 promoter region mutation could partly account for iron overload in the present proband, and that this or other ALAS2 mutations could explain the occurrence of iron overload in other whites or blacks with or without anemia.	Iron	76-80	5'-aminolevulinate synthase 2	Homo sapiens	20-25
15885606-6	2005	We conclude that an ALAS2 promoter region mutation could partly account for iron overload in the present proband, and that this or other ALAS2 mutations could explain the occurrence of iron overload in other whites or blacks with or without anemia.	Iron	185-189	5'-aminolevulinate synthase 2	Homo sapiens	137-142
15885606-7	2005	The occurrence of anemia and iron overload may be discordant in women heterozygous for ALAS2 mutations.	Iron	29-33	5'-aminolevulinate synthase 2	Homo sapiens	87-92
18184803-1	2008	Friedreich"s ataxia (FRDA) is a neurodegenerative disorder arising from a deficit of the mitochondrial iron chaperone, frataxin.	Iron	103-107	frataxin	Drosophila melanogaster	119-127
15980752-0	2005	[Non-HFE related hereditary iron overload].	Iron	28-32	homeostatic iron regulator	Homo sapiens	5-8
18025780-1	2008	BACKGROUND/AIMS: HFE protein controls iron absorption and cycling, and HFE mutations influence iron status.	Iron	38-42	homeostatic iron regulator	Homo sapiens	17-20
15752750-6	2005	The nifH transplastomic form of C. reinhardtii that lacks the chlL gene can still produce chlorophyll in the dark, suggesting that the nifH product can at least partially substitute for the function of the putative "chlorophyll iron protein" encoded by chlL.	Iron	228-232	photochlorophyllide reductase subunit L	Chlamydomonas reinhardtii	62-66
18025780-1	2008	BACKGROUND/AIMS: HFE protein controls iron absorption and cycling, and HFE mutations influence iron status.	Iron	95-99	homeostatic iron regulator	Homo sapiens	71-74
18025780-2	2008	The aim was to evaluate the effect of the HFE genotype on the need for iron and erythropoietin in Italian hemodialysis patients.	Iron	71-75	homeostatic iron regulator	Homo sapiens	42-45
18025780-7	2008	At enrolment, subjects positive for HFE mutations had higher iron stores (ferritin 617 +/- 663 vs. 423 +/- 386 ng/ml, p = 0.05), were receiving less iron (82.5 +/- 66 vs. 110 +/- 154 mg/month, p = 0.05) and a lower r-HuEPO dosage (98 +/- 83 vs. 142 +/- 138 U/kg/week, p = 0.03).	Iron	61-65	homeostatic iron regulator	Homo sapiens	36-39
15878745-3	2005	Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter, DMT1 (Slc11a2), and the Transferrin Receptor (TfR).	Iron	25-29	transferrin receptor	Rattus norvegicus	134-154
15878745-3	2005	Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter, DMT1 (Slc11a2), and the Transferrin Receptor (TfR).	Iron	25-29	transferrin receptor	Rattus norvegicus	156-159
18025780-7	2008	At enrolment, subjects positive for HFE mutations had higher iron stores (ferritin 617 +/- 663 vs. 423 +/- 386 ng/ml, p = 0.05), were receiving less iron (82.5 +/- 66 vs. 110 +/- 154 mg/month, p = 0.05) and a lower r-HuEPO dosage (98 +/- 83 vs. 142 +/- 138 U/kg/week, p = 0.03).	Iron	149-153	homeostatic iron regulator	Homo sapiens	36-39
15878745-9	2005	Increased renal TfR expression was also observed in STZ-diabetic Wistar rats together with elevated cellular iron accumulation.	Iron	109-113	transferrin receptor	Rattus norvegicus	16-19
18025780-8	2008	Consistently during the study period, patients positive for HFE mutations received a lower amount of r-HuEPO (94.5 +/- 63 vs. 186 +/- 344 U/kg/week, p = 0.01) and iron (97 +/- 63 vs. 121 +/- 68 mg/month, p = 0.07).	Iron	163-167	homeostatic iron regulator	Homo sapiens	60-63
15796540-3	2005	The iron center is easily oxidized by a single electron (E(1/2) = -0.57 V vs NHE in CH(3)CN) when confined within the fully reduced macrocycle.	Iron	4-8	solute carrier family 9 member C1	Homo sapiens	77-80
18025780-10	2008	CONCLUSION: HFE mutations reduce the amount of r-HuEPO and iron necessary to support erythropoiesis in hemodialysis.	Iron	59-63	homeostatic iron regulator	Homo sapiens	12-15
18685813-0	2008	MRI-based visualization of iron-labeled CD133+ human endothelial progenitor cells.	Iron	27-31	prominin 1	Homo sapiens	40-45
15817857-1	2005	BACKGROUND: The suggestion that carriers of the HFE C282Y mutation absorb nonheme iron more efficiently than do carriers of the wild type has public health implications for countries where the C282Y mutation is common and foods are fortified with iron.	Iron	82-86	homeostatic iron regulator	Homo sapiens	48-51
15817857-1	2005	BACKGROUND: The suggestion that carriers of the HFE C282Y mutation absorb nonheme iron more efficiently than do carriers of the wild type has public health implications for countries where the C282Y mutation is common and foods are fortified with iron.	Iron	247-251	homeostatic iron regulator	Homo sapiens	48-51
18685813-6	2008	Iron can be effectively introduced into CD133+ EPCs plasma in culture and visualized by changing the MRI signal intensity.	Iron	0-4	prominin 1	Homo sapiens	40-45
18685813-8	2008	CONCLUSION: Iron substance can be applied to label CD133+ cells without cytotoxicity and iron-labeled cells can be visualized by MRI image.	Iron	12-16	prominin 1	Homo sapiens	51-56
19141392-1	2008	Proliferating cells have an absolute requirement for iron, which is delivered by transferrin with subsequent intracellular transport via the transferrin receptor.	Iron	53-57	transferrin	Sus scrofa	81-92
15585668-13	2005	Moreover, FE(Na) was increased in parallel with decreased expression of NHE3, NCC, and Na-K-ATPase.	Iron	10-12	solute carrier family 9 member A3	Rattus norvegicus	72-76
19141392-2	2008	Recent studies have reported that transferrin plays a crucial role in the local regulation of ovarian function, apart from its iron-binding characteristic.	Iron	127-131	transferrin	Sus scrofa	34-45
15777346-4	2005	We studied the iron status in these subjects and correlated the same with the HFE gene mutations.	Iron	15-19	homeostatic iron regulator	Homo sapiens	78-81
18166355-8	2008	CONCLUSIONS: HCV-induced reactive oxygen species may down-regulate hepcidin transcription through inhibition of C/EBPalpha DNA binding activity by C/EBP homology protein, which in turn leads to increased duodenal iron transport and macrophage iron release, causing hepatic iron accumulation.	Iron	213-217	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	112-117
15762692-2	2005	Analogously, the room-temperature photochemical reaction of 1a with [CpFe(C6H6)]PF6 gives the previously reported iron complex [1-Cp-12-tBuNH-1,2,4,12-FeC3B8H10] (3) (yield 82%).	Iron	114-118	sperm associated antigen 17	Homo sapiens	74-83
18166355-8	2008	CONCLUSIONS: HCV-induced reactive oxygen species may down-regulate hepcidin transcription through inhibition of C/EBPalpha DNA binding activity by C/EBP homology protein, which in turn leads to increased duodenal iron transport and macrophage iron release, causing hepatic iron accumulation.	Iron	243-247	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	112-117
18166355-8	2008	CONCLUSIONS: HCV-induced reactive oxygen species may down-regulate hepcidin transcription through inhibition of C/EBPalpha DNA binding activity by C/EBP homology protein, which in turn leads to increased duodenal iron transport and macrophage iron release, causing hepatic iron accumulation.	Iron	243-247	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	112-117
15755831-6	2005	The sensitivity and specificity of TfR and ZnPP were limited by considerable overlap between iron-sufficient, nonanemic children and those with IDA.	Iron	93-97	transferrin receptor	Homo sapiens	35-38
18582596-1	2008	The two mammalian iron regulatory proteins, IRP1 and IRP2, are post-transcriptional regulators of cellular iron homeostasis.	Iron	18-22	aconitase 1	Homo sapiens	44-48
15755831-10	2005	CONCLUSIONS: New diagnostic cutoffs for TfR and ZnPP, based on ROC curve analyses, may improve the performance of these indexes in defining iron status in children.	Iron	140-144	transferrin receptor	Homo sapiens	40-43
18582596-1	2008	The two mammalian iron regulatory proteins, IRP1 and IRP2, are post-transcriptional regulators of cellular iron homeostasis.	Iron	107-111	aconitase 1	Homo sapiens	44-48
18565424-10	2008	Accordingly, iron (Fe) in the liver increased progressively during the disease, whereas in the intestine DMT1 was negatively correlated to Fe.	Iron	139-141	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	105-109
15698609-1	2005	BACKGROUND: The measurement of soluble transferrin receptor (sTfR) has been proposed as a valuable marker of erythropoietic activity and iron status.	Iron	137-141	transferrin receptor	Homo sapiens	39-59
17898788-9	2008	A24 induces TfR-1 endocytosis in lysosomal compartments where the receptor is degraded leading to intracellular iron deprivation.	Iron	112-116	transferrin receptor	Homo sapiens	12-17
15788238-3	2005	If a major purpose of xanthine oxidoreductase is the production of urate to function as an iron chelator and antioxidant, a system for coupling the activity of this enzyme to the availability of catalytically-active metal would be required.	Iron	91-95	xanthine dehydrogenase	Homo sapiens	22-45
18325820-2	2008	HFE participates in the regulation of iron metabolism, its mutations are primary cause of hereditary hemochromatosis and appear to be more frequent in neurodegenerative disorders such as Alzheimer"s disease and amyotrophic lateral sclerosis.	Iron	38-42	homeostatic iron regulator	Homo sapiens	0-3
15710243-3	2005	In this study, we report changes in cellular iron metabolism in scrapie-infected mouse neuroblastoma N2a cells (ScN2a).	Iron	45-49	sodium channel, voltage-gated, type II, alpha	Mus musculus	112-117
15710243-4	2005	We detected twofold lower total cellular iron and calcein-chelatable cytosolic labile iron pool (LIP) in ScN2a cells as compared to the N2a cells.	Iron	41-45	sodium channel, voltage-gated, type II, alpha	Mus musculus	105-110
15710243-4	2005	We detected twofold lower total cellular iron and calcein-chelatable cytosolic labile iron pool (LIP) in ScN2a cells as compared to the N2a cells.	Iron	86-90	sodium channel, voltage-gated, type II, alpha	Mus musculus	105-110
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	66-70	sodium channel, voltage-gated, type II, alpha	Mus musculus	20-25
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	66-70	transferrin receptor	Mus musculus	285-307
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	66-70	transferrin receptor	Mus musculus	309-313
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	sodium channel, voltage-gated, type II, alpha	Mus musculus	20-25
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	transferrin receptor	Mus musculus	285-307
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	transferrin receptor	Mus musculus	309-313
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	sodium channel, voltage-gated, type II, alpha	Mus musculus	20-25
17760563-1	2007	Mammalian IRPs (iron regulatory proteins), IRP1 and IRP2, are cytosolic RNA-binding proteins that post-transcriptionally control the mRNA of proteins involved in storage, transport, and utilization of iron.	Iron	16-20	aconitase 1	Homo sapiens	43-47
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	transferrin receptor	Mus musculus	285-307
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	transferrin receptor	Mus musculus	309-313
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	sodium channel, voltage-gated, type II, alpha	Mus musculus	20-25
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	transferrin receptor	Mus musculus	285-307
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	transferrin receptor	Mus musculus	309-313
15710243-9	2005	ScN2a cells responded normally to iron and iron chelator treatment with respect to the activities of IRP1 and IRP2, and biosynthesis of TfR1 and ferritin.	Iron	34-38	sodium channel, voltage-gated, type II, alpha	Mus musculus	0-5
15710243-9	2005	ScN2a cells responded normally to iron and iron chelator treatment with respect to the activities of IRP1 and IRP2, and biosynthesis of TfR1 and ferritin.	Iron	43-47	sodium channel, voltage-gated, type II, alpha	Mus musculus	0-5
17983220-2	2007	The structure exhibits the first eta2 coordination of hydrazine to iron, which may be relevant to intermediates trapped during nitrogenase turnover.	Iron	67-71	DNA polymerase iota	Homo sapiens	33-37
15710243-10	2005	However, the activities of IRP1 and IRP2, and protein levels of TfR1 and ferritin, were still significantly lower in iron-depleted ScN2a cells as compared to the N2a cells, suggesting lower need for iron in ScN2a cells.	Iron	117-121	transferrin receptor	Mus musculus	64-68
15710243-10	2005	However, the activities of IRP1 and IRP2, and protein levels of TfR1 and ferritin, were still significantly lower in iron-depleted ScN2a cells as compared to the N2a cells, suggesting lower need for iron in ScN2a cells.	Iron	117-121	sodium channel, voltage-gated, type II, alpha	Mus musculus	131-136
15710243-10	2005	However, the activities of IRP1 and IRP2, and protein levels of TfR1 and ferritin, were still significantly lower in iron-depleted ScN2a cells as compared to the N2a cells, suggesting lower need for iron in ScN2a cells.	Iron	117-121	sodium channel, voltage-gated, type II, alpha	Mus musculus	207-212
17828464-4	2007	Frataxin plays a crucial role in iron metabolism and detoxification and interacts with electron transport chain proteins.	Iron	33-37	frataxin	Homo sapiens	0-8
15710569-1	2005	BACKGROUND AND OBJECTIVES: The HFE protein interacts with the transferrin receptor (TfR) to regulate cellular iron uptake.	Iron	110-114	homeostatic iron regulator	Homo sapiens	31-34
15710569-1	2005	BACKGROUND AND OBJECTIVES: The HFE protein interacts with the transferrin receptor (TfR) to regulate cellular iron uptake.	Iron	110-114	transferrin receptor	Homo sapiens	62-82
15710569-1	2005	BACKGROUND AND OBJECTIVES: The HFE protein interacts with the transferrin receptor (TfR) to regulate cellular iron uptake.	Iron	110-114	transferrin receptor	Homo sapiens	84-87
15710569-3	2005	The aim of this study was to investigate whether erythroid iron uptake is directly affected by HFE mutations.	Iron	59-63	homeostatic iron regulator	Homo sapiens	95-98
15710569-9	2005	INTERPRETATION AND CONCLUSIONS: There is evidence that HFE C282Y homozygotes display increased plasma iron turnover and increased erythropoiesis, despite there being no evidence that HFE is expressed in erythroid colonies with a normal HFE genotype.	Iron	102-106	homeostatic iron regulator	Homo sapiens	55-58
15710569-10	2005	It is likely that HFE mutations do not directly alter erythroid iron handling, but alter the supply of iron to the erythroid tissues.	Iron	103-107	homeostatic iron regulator	Homo sapiens	18-21
14739928-8	2004	Therefore, transcriptional activation in response to iron availability involves multiple protein interactions between the Aft1 iron-responsive DNA-binding factor and global regulators such as Nhp6 and Ssn6.	Iron	53-57	transcription regulator CYC8	Saccharomyces cerevisiae S288C	201-205
14739928-8	2004	Therefore, transcriptional activation in response to iron availability involves multiple protein interactions between the Aft1 iron-responsive DNA-binding factor and global regulators such as Nhp6 and Ssn6.	Iron	127-131	transcription regulator CYC8	Saccharomyces cerevisiae S288C	201-205
14705945-1	2004	Iron regulatory protein 1 (IRP1) is a bifunctional protein, which either has aconitase activity or binds to specific mRNA structures to regulate the expression of iron proteins.	Iron	163-167	aconitase 1	Homo sapiens	0-25
14705945-1	2004	Iron regulatory protein 1 (IRP1) is a bifunctional protein, which either has aconitase activity or binds to specific mRNA structures to regulate the expression of iron proteins.	Iron	163-167	aconitase 1	Homo sapiens	27-31
14705945-3	2004	This allowed us to use specific antibodies to develop a blotting system that recognized the iron-free and iron-containing IRP1 forms in the soluble fraction and the RNA-bound IRP1 in the high-speed precipitate fraction of cell extracts.	Iron	106-110	aconitase 1	Homo sapiens	122-126
14705945-5	2004	The results showed that iron-bound aconitase IRP1 is by far the prevalent form in most cells and that the major effect of cellular iron modifications is a shift between free and RNA-bound IRP1.	Iron	24-28	aconitase 1	Homo sapiens	45-49
14705945-5	2004	The results showed that iron-bound aconitase IRP1 is by far the prevalent form in most cells and that the major effect of cellular iron modifications is a shift between free and RNA-bound IRP1.	Iron	24-28	aconitase 1	Homo sapiens	188-192
14705945-5	2004	The results showed that iron-bound aconitase IRP1 is by far the prevalent form in most cells and that the major effect of cellular iron modifications is a shift between free and RNA-bound IRP1.	Iron	131-135	aconitase 1	Homo sapiens	188-192
15641778-0	2005	Assembly of human frataxin is a mechanism for detoxifying redox-active iron.	Iron	71-75	frataxin	Homo sapiens	18-26
15641778-3	2005	Recombinant yeast and human frataxin are able to self-associate in large molecular assemblies that bind and store iron as a ferrihydrite mineral.	Iron	114-118	frataxin	Homo sapiens	28-36
17889392-0	2007	Functional characterization of the gene PA2384 in large-scale gene regulation in response to iron starvation in Pseudomonas aeruginosa.	Iron	93-97	hypothetical protein	Pseudomonas aeruginosa PAO1	40-46
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	207-211	homeostatic iron regulator	Homo sapiens	256-259
17889392-1	2007	The function unknown gene PA2384 of Pseudomonas aeruginosa PAO1 has been previously shown dramatically responsive to iron limitation.	Iron	117-121	hypothetical protein	Pseudomonas aeruginosa PAO1	26-32
14729598-7	2004	Of interest, p53R2 was 158-fold more susceptible to the iron chelator deferoxamine mesylate than hRRM2, although the iron content of the two proteins determined by atomic absorption spectrometer was almost the same.	Iron	56-60	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	13-18
14729598-7	2004	Of interest, p53R2 was 158-fold more susceptible to the iron chelator deferoxamine mesylate than hRRM2, although the iron content of the two proteins determined by atomic absorption spectrometer was almost the same.	Iron	117-121	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	13-18
14729598-10	2004	These inhibition studies showed that the iron center and tyrosyl radical are involved in RR activity for both p53R2 and hRRM2.	Iron	41-45	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	110-115
15222129-1	2004	Iron metabolism might be involved in the pathogenesis of CAD, and C282Y and H63D mutations in the HFE gene are associated with increased serum iron levels and net iron accumulation.	Iron	143-147	homeostatic iron regulator	Homo sapiens	98-101
15222129-1	2004	Iron metabolism might be involved in the pathogenesis of CAD, and C282Y and H63D mutations in the HFE gene are associated with increased serum iron levels and net iron accumulation.	Iron	163-167	homeostatic iron regulator	Homo sapiens	98-101
15354399-2	2004	Lack of frataxin homologues in yeast and mice leads to increased sensitivity to oxidative stress, depletion of proteins with iron-sulfur clusters like respiratory chain complexes I-III and aconitase, and to iron accumulation in mitochondria.	Iron	125-129	frataxin	Homo sapiens	8-16
15354399-2	2004	Lack of frataxin homologues in yeast and mice leads to increased sensitivity to oxidative stress, depletion of proteins with iron-sulfur clusters like respiratory chain complexes I-III and aconitase, and to iron accumulation in mitochondria.	Iron	207-211	frataxin	Homo sapiens	8-16
15159639-8	2004	The transcription intensity of LeFRO1 in roots is dependent on the iron status whereas it is constitutively expressed in leaves.	Iron	67-71	ferric-chelate reductase	Solanum lycopersicum	31-37
15159639-9	2004	These results indicate that LeFRO1 is required in roots and shoots as well as in reproductive organs for iron homeostasis and that its transcription in roots and shoots is regulated by different control mechanisms.	Iron	105-109	ferric-chelate reductase	Solanum lycopersicum	28-34
15159639-10	2004	The expression of LeFRO1 was disrupted in the iron-inefficient mutants chloronerva and T3238 fer, indicating that FER and CHLN genes are involved in the regulation of LeFRO1 expression in tomato roots.	Iron	46-50	ferric-chelate reductase	Solanum lycopersicum	18-24
15159639-10	2004	The expression of LeFRO1 was disrupted in the iron-inefficient mutants chloronerva and T3238 fer, indicating that FER and CHLN genes are involved in the regulation of LeFRO1 expression in tomato roots.	Iron	46-50	bHLH transcriptional regulator	Solanum lycopersicum	93-96
15159639-10	2004	The expression of LeFRO1 was disrupted in the iron-inefficient mutants chloronerva and T3238 fer, indicating that FER and CHLN genes are involved in the regulation of LeFRO1 expression in tomato roots.	Iron	46-50	bHLH transcriptional regulator	Solanum lycopersicum	114-117
15159639-10	2004	The expression of LeFRO1 was disrupted in the iron-inefficient mutants chloronerva and T3238 fer, indicating that FER and CHLN genes are involved in the regulation of LeFRO1 expression in tomato roots.	Iron	46-50	ferric-chelate reductase	Solanum lycopersicum	167-173
15159639-11	2004	The differential expression of LeFRO1 and LeIRT1 (an iron-regulated metal transporter gene in tomato) in roots of T3238 fer under iron-deficient and -sufficient conditions suggests that the FER gene may regulate expression of LeFRO1 more directly than that of LeIRT1 in tomato roots.	Iron	53-57	ferric-chelate reductase	Solanum lycopersicum	31-37
15159639-11	2004	The differential expression of LeFRO1 and LeIRT1 (an iron-regulated metal transporter gene in tomato) in roots of T3238 fer under iron-deficient and -sufficient conditions suggests that the FER gene may regulate expression of LeFRO1 more directly than that of LeIRT1 in tomato roots.	Iron	53-57	bHLH transcriptional regulator	Solanum lycopersicum	7-10
15159639-11	2004	The differential expression of LeFRO1 and LeIRT1 (an iron-regulated metal transporter gene in tomato) in roots of T3238 fer under iron-deficient and -sufficient conditions suggests that the FER gene may regulate expression of LeFRO1 more directly than that of LeIRT1 in tomato roots.	Iron	53-57	bHLH transcriptional regulator	Solanum lycopersicum	190-193
15159639-11	2004	The differential expression of LeFRO1 and LeIRT1 (an iron-regulated metal transporter gene in tomato) in roots of T3238 fer under iron-deficient and -sufficient conditions suggests that the FER gene may regulate expression of LeFRO1 more directly than that of LeIRT1 in tomato roots.	Iron	53-57	ferric-chelate reductase	Solanum lycopersicum	226-232
15013295-3	2004	Recently, the soluble transferrin receptor (s-TfR) has been considered to be a marker of functional iron stores.	Iron	100-104	transferrin receptor	Homo sapiens	46-49
15077974-3	2004	Because the generation rate of ferrous ions is one of the key parameters in evaluating the oxidation efficiency of the reaction system, the initial current efficiencies (eta(i)) for iron (III) reduction are examined first.	Iron	182-186	endothelin receptor type A	Homo sapiens	170-173
14685669-3	2003	With an allele frequency of 5-10% for the C282Y mutation and 6-30% for the H63D mutation, there is a frequent coincidence of hemochromatosis (HFE) mutations and chronic hepatitis C. There is increasing evidence that HFE homozygosity and even HFE heterozygosity are associated with an increased liver iron concentration and liver fibrosis progression in chronic hepatitis C. In addition, present data suggest an impact of iron on the outcome of interferon therapy.	Iron	300-304	homeostatic iron regulator	Homo sapiens	142-145
14685669-3	2003	With an allele frequency of 5-10% for the C282Y mutation and 6-30% for the H63D mutation, there is a frequent coincidence of hemochromatosis (HFE) mutations and chronic hepatitis C. There is increasing evidence that HFE homozygosity and even HFE heterozygosity are associated with an increased liver iron concentration and liver fibrosis progression in chronic hepatitis C. In addition, present data suggest an impact of iron on the outcome of interferon therapy.	Iron	300-304	homeostatic iron regulator	Homo sapiens	216-219
14685669-3	2003	With an allele frequency of 5-10% for the C282Y mutation and 6-30% for the H63D mutation, there is a frequent coincidence of hemochromatosis (HFE) mutations and chronic hepatitis C. There is increasing evidence that HFE homozygosity and even HFE heterozygosity are associated with an increased liver iron concentration and liver fibrosis progression in chronic hepatitis C. In addition, present data suggest an impact of iron on the outcome of interferon therapy.	Iron	300-304	homeostatic iron regulator	Homo sapiens	216-219
14685669-3	2003	With an allele frequency of 5-10% for the C282Y mutation and 6-30% for the H63D mutation, there is a frequent coincidence of hemochromatosis (HFE) mutations and chronic hepatitis C. There is increasing evidence that HFE homozygosity and even HFE heterozygosity are associated with an increased liver iron concentration and liver fibrosis progression in chronic hepatitis C. In addition, present data suggest an impact of iron on the outcome of interferon therapy.	Iron	421-425	homeostatic iron regulator	Homo sapiens	142-145
14685669-3	2003	With an allele frequency of 5-10% for the C282Y mutation and 6-30% for the H63D mutation, there is a frequent coincidence of hemochromatosis (HFE) mutations and chronic hepatitis C. There is increasing evidence that HFE homozygosity and even HFE heterozygosity are associated with an increased liver iron concentration and liver fibrosis progression in chronic hepatitis C. In addition, present data suggest an impact of iron on the outcome of interferon therapy.	Iron	421-425	homeostatic iron regulator	Homo sapiens	216-219
14685669-3	2003	With an allele frequency of 5-10% for the C282Y mutation and 6-30% for the H63D mutation, there is a frequent coincidence of hemochromatosis (HFE) mutations and chronic hepatitis C. There is increasing evidence that HFE homozygosity and even HFE heterozygosity are associated with an increased liver iron concentration and liver fibrosis progression in chronic hepatitis C. In addition, present data suggest an impact of iron on the outcome of interferon therapy.	Iron	421-425	homeostatic iron regulator	Homo sapiens	216-219
12954629-4	2003	Deletion of FET3 leads to iron deficiency; this deletion also causes a copper sensitivity not seen in wild type.	Iron	26-30	ferroxidase FET3	Saccharomyces cerevisiae S288C	12-16
12954629-14	2003	These biochemical and physiologic results indicate that at least with respect to cuprous and ferrous ions, Fet3p can be considered a metallo-oxidase and appears to play an essential role in both iron and copper homeostasis in yeast.	Iron	195-199	ferroxidase FET3	Saccharomyces cerevisiae S288C	107-112
14635204-1	2003	Three polymorphic gene mutations in the human hemochromatosis (HFE) gene (C282Y, H63D, S65C) are associated with non-transfusion-related iron overload in Caucasians.	Iron	137-141	homeostatic iron regulator	Homo sapiens	63-66
12961032-5	2003	We propose a synergistic effect of HS and mutations in HFE as the cause of the iron deposits.	Iron	79-83	homeostatic iron regulator	Homo sapiens	55-58
14633868-0	2003	Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload.	Iron	162-166	homeostatic iron regulator	Homo sapiens	39-42
14641138-2	2003	In recent years, the soluble transferrin receptor (sTfR) has been introduced as a sensitive, early and highly quantitative new marker of iron depletion, increasing in proportion to tissue iron deficit.	Iron	137-141	transferrin receptor	Homo sapiens	29-49
14641138-2	2003	In recent years, the soluble transferrin receptor (sTfR) has been introduced as a sensitive, early and highly quantitative new marker of iron depletion, increasing in proportion to tissue iron deficit.	Iron	188-192	transferrin receptor	Homo sapiens	29-49
14691533-11	2003	From these data, we propose a structure-based model for the mechanism of TfR-assisted iron release from Fe-Tf.	Iron	86-90	transferrin receptor	Homo sapiens	73-76
12968028-10	2003	PheA2 is structurally related to ferric reductase, an NAD(P)H-dependent reductase from the hyperthermophilic Archaea Archaeoglobus fulgidus that catalyzes the flavin-mediated reduction of iron complexes.	Iron	188-192	ferric reductase	Parageobacillus thermoglucosidasius	33-49
13129917-9	2003	We also present evidence that AtOPT3, a member of the oligopeptide transporter gene family with significant similarities to the maize iron-phytosiderophore transporter YS1, is regulated by metals and heterologous expression AtOPT3 can rescue yeast mutants deficient in metal transport.	Iron	134-138	oligopeptide transporter	Arabidopsis thaliana	30-36
13129917-9	2003	We also present evidence that AtOPT3, a member of the oligopeptide transporter gene family with significant similarities to the maize iron-phytosiderophore transporter YS1, is regulated by metals and heterologous expression AtOPT3 can rescue yeast mutants deficient in metal transport.	Iron	134-138	oligopeptide transporter	Arabidopsis thaliana	224-230
12881306-1	2003	Transferrin receptor (TfR) facilitates cellular iron uptake by mediating endocytosis of its ligand, iron-loaded transferrin.	Iron	48-52	transferrin receptor	Homo sapiens	0-20
12881306-1	2003	Transferrin receptor (TfR) facilitates cellular iron uptake by mediating endocytosis of its ligand, iron-loaded transferrin.	Iron	48-52	transferrin receptor	Homo sapiens	22-25
12881306-1	2003	Transferrin receptor (TfR) facilitates cellular iron uptake by mediating endocytosis of its ligand, iron-loaded transferrin.	Iron	100-104	transferrin receptor	Homo sapiens	0-20
12881306-1	2003	Transferrin receptor (TfR) facilitates cellular iron uptake by mediating endocytosis of its ligand, iron-loaded transferrin.	Iron	100-104	transferrin receptor	Homo sapiens	22-25
12881306-2	2003	Although TfR is widely believed to be important for iron acquisition by all mammalian cells, direct experimental evidence is lacking.	Iron	52-56	transferrin receptor	Homo sapiens	9-12
15528200-10	2005	The Km values of At-P4H-2 for the reaction cosubstrates Fe2+, 2-oxoglutarate, and ascorbate were similar to those of At-P4H-1 with the exception that the Km for iron was about 3-fold lower.	Iron	161-165	P4H 	Arabidopsis thaliana	20-23
16403978-1	2005	Iron regulatory proteins (IRP1 and 2) function as translational regulators that coordinate the cellular iron metabolism of eukaryotes by binding to the mRNA of target genes such as the transferrin receptor or ferritin.	Iron	0-4	aconitase 1	Homo sapiens	26-36
16403978-1	2005	Iron regulatory proteins (IRP1 and 2) function as translational regulators that coordinate the cellular iron metabolism of eukaryotes by binding to the mRNA of target genes such as the transferrin receptor or ferritin.	Iron	104-108	aconitase 1	Homo sapiens	26-36
16403978-3	2005	As iron and oxygen are essential but potentially toxic constituents of most organisms, ROS-mediated modulation of IRP1 activity may be an important regulatory element in dissecting iron homeostasis and oxidative stress.	Iron	3-7	aconitase 1	Homo sapiens	114-118
16403978-3	2005	As iron and oxygen are essential but potentially toxic constituents of most organisms, ROS-mediated modulation of IRP1 activity may be an important regulatory element in dissecting iron homeostasis and oxidative stress.	Iron	181-185	aconitase 1	Homo sapiens	114-118
16403978-4	2005	The responses of IRP1 towards reactive oxygen species are compartment-specific and rather complex: H2O2 activates IRP1 via a signaling cascade that leads to upregulation of the transferrin receptor and cellular iron accumulation.	Iron	211-215	aconitase 1	Homo sapiens	17-21
16403978-4	2005	The responses of IRP1 towards reactive oxygen species are compartment-specific and rather complex: H2O2 activates IRP1 via a signaling cascade that leads to upregulation of the transferrin receptor and cellular iron accumulation.	Iron	211-215	aconitase 1	Homo sapiens	114-118
16403978-6	2005	In particular, activation of IRP1 by H2O2 has established a new regulatory link between inflammation and iron metabolism with new clinical implications.	Iron	105-109	aconitase 1	Homo sapiens	29-33
15668490-2	2005	Some individuals who are heterozygous for mutations in the hemochromatosis gene (HFE) have higher than average serologic measures of iron.	Iron	133-137	homeostatic iron regulator	Homo sapiens	81-84
16103673-0	2005	Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway.	Iron	0-4	homeostatic iron regulator	Homo sapiens	55-58
16103673-1	2005	BACKGROUND/AIMS: In HFE-related hereditary hemochromatosis an inappropriately low hepatic expression of the iron-regulatory peptide hepcidin (encoded by HAMP) has been suggested to cause iron overload.	Iron	108-112	homeostatic iron regulator	Homo sapiens	20-23
16103673-1	2005	BACKGROUND/AIMS: In HFE-related hereditary hemochromatosis an inappropriately low hepatic expression of the iron-regulatory peptide hepcidin (encoded by HAMP) has been suggested to cause iron overload.	Iron	187-191	homeostatic iron regulator	Homo sapiens	20-23
16103673-2	2005	The aim of the present study was to evaluate whether the hepatic expression of HAMP in relation to iron stores requires HFE or might involve other important iron-related genes including HJV (encoding hemojuvelin) and TFR2 (encoding transferrin receptor-2).	Iron	99-103	homeostatic iron regulator	Homo sapiens	120-123
16103673-7	2005	CONCLUSION: The central pathogenetic step in HFE-related hemochromatosis is an impaired basal expression of HAMP rather than a lack of HAMP upregulation in response to iron stores.	Iron	168-172	homeostatic iron regulator	Homo sapiens	45-48
16103673-8	2005	An HFE-independent pathway that seems to involve TFR2 and HJV can regulate HAMP expression under conditions of iron overload.	Iron	111-115	homeostatic iron regulator	Homo sapiens	3-6
15574383-5	2005	Besides divalent metal transporters of the Nramp type and ferrous iron transport proteins of the Feo type, four distinct families of ABC transporters related to iron uptake are known.	Iron	66-70	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	133-136
15574383-5	2005	Besides divalent metal transporters of the Nramp type and ferrous iron transport proteins of the Feo type, four distinct families of ABC transporters related to iron uptake are known.	Iron	161-165	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	133-136
15694690-5	2005	Recently, we found that the ATM gene product (mutated in ataxia-telangiectasia, A-T), is required for cell survival and genomic stability maintenance following exposure to low labile iron concentrations.	Iron	183-187	ataxia telangiectasia mutated	Mus musculus	28-31
15694690-6	2005	Iron chelators (desferal, quercetin, and apoferritin) also increase A-T cell genomic stability and viability, and activate ATM-dependent cellular events in normal cells.	Iron	0-4	ataxia telangiectasia mutated	Mus musculus	123-126
15694690-8	2005	Based on this, we propose that iron chelators protect the substantia nigra pars compacta not only by chelating labile iron and reducing oxyradical formation, but also by inducing ATM activity, leading to increased oxidative stress resistance and DNA repair.	Iron	31-35	ataxia telangiectasia mutated	Mus musculus	179-182
15694690-9	2005	Support for this hypothesis comes from the recent observation that the iron chelating flavonoid quercetin both directly activates ATM and protects neuronal cells from the toxic effects of the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	Iron	71-75	ataxia telangiectasia mutated	Mus musculus	130-133
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Iron	41-45	ataxia telangiectasia mutated	Mus musculus	21-24
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Iron	71-75	ataxia telangiectasia mutated	Mus musculus	138-141
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Iron	71-75	ataxia telangiectasia mutated	Mus musculus	138-141
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Iron	71-75	ataxia telangiectasia mutated	Mus musculus	138-141
15694690-11	2005	Furthermore, pharmacological manipulation of ATM activity via iron chelation might have clinical efficacy in PD treatment.	Iron	62-66	ataxia telangiectasia mutated	Mus musculus	45-48
16291259-1	2005	In this chapter, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to oxidants.	Iron	63-67	transferrin receptor	Homo sapiens	33-53
15724439-1	2005	At least two proteins binding to iron regulatory elements (IRE) in mRNA are known, designated as iron regulatory proteins (IRP) 1 and 2.	Iron	33-37	aconitase 1	Homo sapiens	97-135
15604406-1	2004	The iron-regulatory proteins (IRPs) posttranscriptionally regulate expression of transferrin receptor, ferritin, and other iron metabolism proteins.	Iron	4-8	transferrin receptor	Homo sapiens	81-101
15548613-3	2004	Unlike in Mb, in Ngb the sixth coordination position of the heme iron is occupied by the distal histidine, in the absence of an exogenous ligand.	Iron	65-69	neuroglobin	Mus musculus	17-20
15504367-1	2004	myo-Inositol oxygenase (MIOX) is a non-heme iron enzyme, which catalyzes the conversion of myo-inositol to d-glucuronic acid, the first committed step in myo-inositol catabolism.	Iron	44-48	myo-inositol oxygenase	Homo sapiens	4-22
15504367-1	2004	myo-Inositol oxygenase (MIOX) is a non-heme iron enzyme, which catalyzes the conversion of myo-inositol to d-glucuronic acid, the first committed step in myo-inositol catabolism.	Iron	44-48	myo-inositol oxygenase	Homo sapiens	24-28
15556641-2	2004	In tomato, the basic helix-loop-helix gene FER is required for induction of iron mobilization.	Iron	76-80	bHLH transcriptional regulator	Solanum lycopersicum	43-46
15556641-3	2004	Using molecular-genetic techniques, we analyzed the function of BHLH029, named FRU (FER-like regulator of iron uptake), the Arabidopsis thaliana homolog of the tomato FER gene.	Iron	106-110	bHLH transcriptional regulator	Solanum lycopersicum	84-87
15556641-5	2004	FRU mutant plants were chlorotic, and the FRU gene was found necessary for induction of the essential iron mobilization genes FRO2 (ferric chelate reductase gene) and IRT1 (iron-regulated transporter gene).	Iron	102-106	ferric reduction oxidase 2	Arabidopsis thaliana	126-130
15521925-8	2004	Although human TfR1 and TfR2 alpha share an essential structure (RGD) for ligand-binding, they have clearly different ligand specificities, which may be related to the differences in their roles in iron metabolism.	Iron	198-202	transferrin receptor	Homo sapiens	15-19
15804829-6	2004	Ngb and Cgb display the classical three-over-three alpha-helical fold of Hb and Mb, and are endowed with a hexa-coordinate heme-Fe atom, in their ferrous and ferric forms, having the heme distal HisE7 residue as the endogenous ligand.	Iron	128-130	chorionic gonadotropin subunit beta 5	Homo sapiens	8-11
16265043-6	2004	Circumstantial evidence indicates that the effect of circulatory iron on hepcidin requires functional HFE and hemojuvelin, two proteins of unknown function that have recently been linked to human hereditary hemochromatosis.	Iron	65-69	homeostatic iron regulator	Homo sapiens	102-105
15474026-1	2004	Frataxin is a highly conserved protein from bacteria to mammals that has been proposed to participate in iron-sulfur cluster assembly and mitochondrial iron homeostasis.	Iron	105-109	frataxin	Homo sapiens	0-8
15474026-1	2004	Frataxin is a highly conserved protein from bacteria to mammals that has been proposed to participate in iron-sulfur cluster assembly and mitochondrial iron homeostasis.	Iron	152-156	frataxin	Homo sapiens	0-8
15474026-2	2004	In higher organisms, the frataxin gene is nuclear-encoded and the protein is required for maintenance of normal mitochondrial iron levels and respiration.	Iron	126-130	frataxin	Homo sapiens	25-33
15336622-5	2004	We also show that labile iron levels are significantly elevated in Atm-deficient mouse sera compared to syngeniec wild type mice.	Iron	25-29	ataxia telangiectasia mutated	Mus musculus	67-70
15727249-0	2004	Frequency of HFE H63D, S65C, and C282Y mutations in patients with iron overload and controls from Toledo, Spain.	Iron	66-70	homeostatic iron regulator	Homo sapiens	13-16
15282205-3	2004	Mitochondria iron overload occurs also in cells deficient in frataxin, a mitochondrial protein involved in iron handling and implicated in Friedreich ataxia.	Iron	13-17	frataxin	Homo sapiens	61-69
15282205-3	2004	Mitochondria iron overload occurs also in cells deficient in frataxin, a mitochondrial protein involved in iron handling and implicated in Friedreich ataxia.	Iron	107-111	frataxin	Homo sapiens	61-69
15282205-6	2004	MtF expression rescued the respiratory deficiency caused by the loss of frataxin protecting the activity of iron-sulfur enzymes and enabling frataxin-deficient cells to grow on non-fermentable carbon sources.	Iron	108-112	frataxin	Homo sapiens	72-80
15282205-8	2004	The data show that MtF can substitute for most frataxin functions in yeast, suggesting that frataxin is directly involved in mitochondrial iron-binding and detoxification.	Iron	139-143	frataxin	Homo sapiens	92-100
15385478-0	2004	The Ton system, an ABC transporter, and a universally conserved GTPase are involved in iron utilization by Brucella melitensis 16M.	Iron	87-91	ABC transporter permease subunit	Brucella melitensis bv. 1 str. 16M	19-34
15385478-7	2004	ExbB is part of the Ton complex, and DstC is a permease homologue of an iron(III) ABC transporter; in gram-negative bacteria these two complexes are involved in the uptake of iron through the outer and inner membranes, respectively.	Iron	72-76	ABC transporter permease subunit	Brucella melitensis bv. 1 str. 16M	82-97
15480846-13	2004	Such drug would prevent participation of elevated iron in oxidative stress and formation of reactive hydroxyl radical, via its interaction with H(2)O2 (Fenton chemistry), generated as a consequence MAO and other oxidative enzyme reactions to generative cytotoxic reactive hydroxyl radical.	Iron	50-54	monoamine oxidase A	Rattus norvegicus	198-201
15349772-4	2004	Band-shift assays revealed that T. gondii infection resulted in increased activity in the iron response protein IRP1, which, in this state, stabilizes TfR mRNA from degradation.	Iron	90-94	transferrin receptor	Homo sapiens	151-154
15349772-9	2004	Together our findings suggest that the T. gondii-specific TfR up-regulation is not due to a direct interaction of parasitic factors with the iron-uptake machinery of the host cell but is instead mediated indirectly as a result of secreted host cell- or parasite-derived factors.	Iron	141-145	transferrin receptor	Homo sapiens	58-61
15247288-1	2004	Increasing evidence suggests that IscS, a cysteine desulfurase, provides sulfur for assembly of transient iron-sulfur clusters in IscU.	Iron	106-110	NFS1 cysteine desulfurase	Homo sapiens	34-38
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	21-25	NFS1 cysteine desulfurase	Homo sapiens	202-206
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	NFS1 cysteine desulfurase	Homo sapiens	202-206
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	NFS1 cysteine desulfurase	Homo sapiens	202-206
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	NFS1 cysteine desulfurase	Homo sapiens	202-206
15247288-5	2004	Remarkably, IscA, an iron-sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to overcome the iron limitation due to sodium citrate and deliver iron for the IscS-mediated iron-sulfur cluster assembly in IscU.	Iron	66-70	NFS1 cysteine desulfurase	Homo sapiens	202-206
15155465-1	2004	A mutation of the iron transporter Nramp2 (DMT1, Slc11a2) causes microcytic anemia in mk mice and in Belgrade rats by impairing iron absorption in the duodenum and in erythroid cells, causing severe iron deficiency.	Iron	18-22	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	35-41
15155465-1	2004	A mutation of the iron transporter Nramp2 (DMT1, Slc11a2) causes microcytic anemia in mk mice and in Belgrade rats by impairing iron absorption in the duodenum and in erythroid cells, causing severe iron deficiency.	Iron	18-22	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	43-47
15155465-1	2004	A mutation of the iron transporter Nramp2 (DMT1, Slc11a2) causes microcytic anemia in mk mice and in Belgrade rats by impairing iron absorption in the duodenum and in erythroid cells, causing severe iron deficiency.	Iron	18-22	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	49-56
15304122-4	2004	Additionally, we studied the role of HFE gene mutations in iron deposits.	Iron	59-63	homeostatic iron regulator	Homo sapiens	37-40
15276847-0	2004	Iron binding and oxidation kinetics in frataxin CyaY of Escherichia coli.	Iron	0-4	frataxin	Homo sapiens	39-47
15276847-2	2004	Here, we investigate the iron binding and oxidation chemistry of Escherichia coli frataxin (CyaY), a homologue of human frataxin, with the aim of better understanding the functional properties of this protein.	Iron	25-29	frataxin	Homo sapiens	82-90
15276847-11	2004	The observed iron oxidation and binding properties of frataxin CyaY may afford the mitochondria protection against iron-induced oxidative damage.	Iron	13-17	frataxin	Homo sapiens	54-62
15276847-11	2004	The observed iron oxidation and binding properties of frataxin CyaY may afford the mitochondria protection against iron-induced oxidative damage.	Iron	115-119	frataxin	Homo sapiens	54-62
15259365-2	2004	These toxic effects are caused by inhibition of heme synthesis and, as a consequence, transferrin receptor (TfR) number appears increased and so iron taken up by cells.	Iron	145-149	transferrin receptor	Homo sapiens	86-106
15259365-2	2004	These toxic effects are caused by inhibition of heme synthesis and, as a consequence, transferrin receptor (TfR) number appears increased and so iron taken up by cells.	Iron	145-149	transferrin receptor	Homo sapiens	108-111
18079564-1	2007	HFE-related hereditary haemochromatosis (HH) is an iron overload disease attributed to the highly prevalent homozygosity for the C282Y mutation in the HFE gene.	Iron	51-55	homeostatic iron regulator	Homo sapiens	151-154
15271519-2	2004	The impact of zinc and cadmium on the main regulators of iron homeostasis in metazoans, the iron regulatory proteins (IRP) 1 and 2, has been probed with the human recombinant proteins.	Iron	92-96	aconitase 1	Homo sapiens	118-130
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Iron	53-57	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	153-157
18079564-6	2007	Therefore, screening to facilitate early diagnosis is desirable in individuals at risk of developing HFE-related iron overload.	Iron	113-117	homeostatic iron regulator	Homo sapiens	101-104
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Iron	183-187	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	153-157
18079569-1	2007	Hereditary haemochromatosis (HH) is a disease related to mutations in the HFE gene and can lead to progressive iron accumulation, especially in the liver, eventually resulting in organ damage.	Iron	111-115	homeostatic iron regulator	Homo sapiens	74-77
18079569-8	2007	iron accumulation confirmed by magnetic resonance imaging (MRI) in the absence of the homozygous C282Y mutation or the combined C282Y/H63d genotype may justify a search for rare hereditary forms of non-HFE HH in a specialised centre.	Iron	0-4	homeostatic iron regulator	Homo sapiens	202-205
17849083-3	2007	A central role in regulating iron/oxygen chemistry in animals is played by mRNA translation or turnover via the iron responsive element (IRE)/iron regulatory protein (IRP) system.	Iron	29-33	Wnt family member 2	Homo sapiens	167-170
15225610-3	2004	A deletion of ATM1 results in the accumulation of up to a 30-fold excess of mitochondrial iron, loss of mitochondrial cytochromes and abnormalities of cytosolic iron metabolism.	Iron	90-94	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	14-18
15225610-3	2004	A deletion of ATM1 results in the accumulation of up to a 30-fold excess of mitochondrial iron, loss of mitochondrial cytochromes and abnormalities of cytosolic iron metabolism.	Iron	161-165	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	14-18
17849083-3	2007	A central role in regulating iron/oxygen chemistry in animals is played by mRNA translation or turnover via the iron responsive element (IRE)/iron regulatory protein (IRP) system.	Iron	112-116	Wnt family member 2	Homo sapiens	167-170
17410459-1	2007	We aimed to determine the relationships between iron overload and HFE gene mutation in chronic liver disease in Turkey.	Iron	48-52	homeostatic iron regulator	Homo sapiens	66-69
15186942-2	2004	We investigated the effect of extracellular Mg2+ on Fe-catalyzed lipid peroxidation in rat aortic segments and in human aortic smooth muscle cells.	Iron	52-54	mucin 7, secreted	Homo sapiens	44-47
15196016-8	2004	In the Rnr2 homodimer, one of the iron-binding helices, helix alphaB, is not well-ordered.	Iron	34-38	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	7-11
15196016-9	2004	In the heterodimer, interactions with a loop region connecting Rnr4 helices alphaA and alpha3 stabilize this Rnr2 helix, which donates iron ligand Asp 145.	Iron	135-139	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	63-67
15196016-9	2004	In the heterodimer, interactions with a loop region connecting Rnr4 helices alphaA and alpha3 stabilize this Rnr2 helix, which donates iron ligand Asp 145.	Iron	135-139	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	109-113
15056661-1	2004	Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis.	Iron	87-91	transferrin receptor	Homo sapiens	0-20
15056661-1	2004	Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis.	Iron	87-91	transferrin receptor	Homo sapiens	22-25
15056661-1	2004	Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis.	Iron	87-91	homeostatic iron regulator	Homo sapiens	123-137
15161286-4	2004	In this study, mutations at the E185 and Y354 residues, which are putative ligands for iron in Fet3p, have been generated and characterized.	Iron	87-91	ferroxidase FET3	Saccharomyces cerevisiae S288C	95-100
15161286-7	2004	The iron binding sites in Fet3p and hCp appear to be very similar in nature, and their contributions to the ferroxidase activity of these proteins have been analyzed.	Iron	4-8	ferroxidase FET3	Saccharomyces cerevisiae S288C	26-31
15161286-7	2004	The iron binding sites in Fet3p and hCp appear to be very similar in nature, and their contributions to the ferroxidase activity of these proteins have been analyzed.	Iron	4-8	alpha-1-microglobulin/bikunin precursor	Homo sapiens	36-39
15168383-13	2004	CONCLUSION: We show for the first time that increased iron levels in PMNLs of HD patients were associated with downregulation of ferroportin 1 and upregulation of TfR, which might be linked to hypercytokinemia.	Iron	54-58	transferrin receptor	Homo sapiens	163-166
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	49-53	transferrin receptor	Mus musculus	59-80
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	49-53	transferrin receptor	Mus musculus	82-85
15165186-5	2004	However, when challenged with photoinhibitory treatments at high light or low temperature, or with iron (Fe) or copper (Cu) overload, the tAPX-overexpressing lines show no increased resistance with respect to controls, indicating that in such experimental conditions, tAPX overexpression does not reinforce plant defenses against the oxidative stresses tested.	Iron	99-103	thylakoidal ascorbate peroxidase	Arabidopsis thaliana	138-142
15165186-5	2004	However, when challenged with photoinhibitory treatments at high light or low temperature, or with iron (Fe) or copper (Cu) overload, the tAPX-overexpressing lines show no increased resistance with respect to controls, indicating that in such experimental conditions, tAPX overexpression does not reinforce plant defenses against the oxidative stresses tested.	Iron	105-107	thylakoidal ascorbate peroxidase	Arabidopsis thaliana	138-142
15352740-1	2004	Epidemiological studies indicate a positive relation between iron status and coronary artery disease (CAD) risk The HFE C282Y allele is associated with increased iron status and higher CAD risk.	Iron	61-65	homeostatic iron regulator	Homo sapiens	116-119
15352740-1	2004	Epidemiological studies indicate a positive relation between iron status and coronary artery disease (CAD) risk The HFE C282Y allele is associated with increased iron status and higher CAD risk.	Iron	162-166	homeostatic iron regulator	Homo sapiens	116-119
15016813-1	2004	We have examined the effects of active site residues on ligand binding to the heme iron of mouse neuroglobin using steady-state and time-resolved visible spectroscopy.	Iron	83-87	neuroglobin	Mus musculus	97-108
15103330-0	2004	The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins.	Iron	80-84	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	21-26
15103330-4	2004	Here, we demonstrate that Nar1p is predominantly located in the cytosol and contains two adjacent iron-sulphur (Fe/S) clusters.	Iron	98-102	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	26-31
15103330-4	2004	Here, we demonstrate that Nar1p is predominantly located in the cytosol and contains two adjacent iron-sulphur (Fe/S) clusters.	Iron	112-114	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	26-31
15103330-5	2004	Assembly of its Fe/S clusters crucially depends on components of the mitochondrial Fe/S cluster biosynthesis apparatus such as the cysteine desulphurase Nfs1p, the ferredoxin Yah1p and the ABC transporter Atm1p.	Iron	16-18	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	205-210
15103330-5	2004	Assembly of its Fe/S clusters crucially depends on components of the mitochondrial Fe/S cluster biosynthesis apparatus such as the cysteine desulphurase Nfs1p, the ferredoxin Yah1p and the ABC transporter Atm1p.	Iron	83-85	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	205-210
15054143-5	2004	Our results showed that DMT1, FP1, hephaestin, and TfR1 mRNA levels were significantly increased in CD patients with reduced body iron stores compared with controls, similar to what was observed in anemic patients.	Iron	130-134	transferrin receptor	Homo sapiens	51-55
15054143-10	2004	These changes were paralleled by IRP activity, which increased in all iron-deficient subjects.	Iron	70-74	Wnt family member 2	Homo sapiens	33-36
15054143-11	2004	We conclude that duodenal DMT1, FP1, hephaestin, and TfR1 expression and IRP activity, thus the iron absorption capacity, are upregulated in CD patients as a consequence of iron deficiency, whereas the increased enterocyte proliferation observed in CD has no effect on iron uptake regulation.	Iron	96-100	transferrin receptor	Homo sapiens	53-57
15703644-5	2004	Highlights this year include the discovery of a new gene involved in iron metabolism, hemojuvelin, and new data on the role of HFE mutations in the development of iron overload.	Iron	163-167	homeostatic iron regulator	Homo sapiens	127-130
15130665-3	2004	The only potential iron storage protein identified in yeast so far is the homologue of human frataxin (YFH1p).	Iron	19-23	frataxin	Homo sapiens	93-101
15130665-5	2004	Interestingly, the human ferritin L gene can, at least partially, complement the function of yeast frataxin, extending lifespan and protecting cells from death induced by oxidative stress or excess iron.	Iron	198-202	frataxin	Homo sapiens	99-107
15082582-5	2004	Duodenal expression of the iron transport molecules DMT1, Dcytb, and Ireg1 increased during pregnancy, and this corresponded with a reduction in hepcidin, HFE, and transferrin receptor 2 expression in the liver.	Iron	27-31	cytochrome b reductase 1	Rattus norvegicus	58-63
15082582-5	2004	Duodenal expression of the iron transport molecules DMT1, Dcytb, and Ireg1 increased during pregnancy, and this corresponded with a reduction in hepcidin, HFE, and transferrin receptor 2 expression in the liver.	Iron	27-31	homeostatic iron regulator	Rattus norvegicus	155-158
15048869-2	2004	A non-classical class I MHC molecule, the hemochromatosis factor HFE, has been shown to regulate iron metabolism, potentially via its direct interaction with the transferrin receptor (TfR).	Iron	97-101	homeostatic iron regulator	Homo sapiens	65-68
15048869-2	2004	A non-classical class I MHC molecule, the hemochromatosis factor HFE, has been shown to regulate iron metabolism, potentially via its direct interaction with the transferrin receptor (TfR).	Iron	97-101	transferrin receptor	Homo sapiens	162-182
15048869-2	2004	A non-classical class I MHC molecule, the hemochromatosis factor HFE, has been shown to regulate iron metabolism, potentially via its direct interaction with the transferrin receptor (TfR).	Iron	97-101	transferrin receptor	Homo sapiens	184-187
15048869-7	2004	These findings of incongruent sHFE activity suggest that either variation in affinity binding of sHFE to TfR prevents efficient modulation of iron-regulated proteins or that HFE has multiple functions some of which may be independent of TfR but dependent on interactions within the endosomal compartment for effective modulation of iron metabolism.	Iron	142-146	transferrin receptor	Homo sapiens	105-108
15048869-7	2004	These findings of incongruent sHFE activity suggest that either variation in affinity binding of sHFE to TfR prevents efficient modulation of iron-regulated proteins or that HFE has multiple functions some of which may be independent of TfR but dependent on interactions within the endosomal compartment for effective modulation of iron metabolism.	Iron	332-336	transferrin receptor	Homo sapiens	105-108
15070370-6	2004	The major iron-containing product formed from this step is the diamagnetic cyclohexadienyl complex, [PhBP3]Fe(eta5-cyclohexadienyl), which has also been independently prepared and structurally characterized.	Iron	10-14	PHB1 pseudogene 3	Homo sapiens	101-106
15053632-13	2004	The Fe-O 2.041(5) A and Fe-C(21) 2.192(5) A distances suggests a direct interaction between the iron center and the pi electron density on the carbonyl group in a eta2 fashion.	Iron	96-100	DNA polymerase iota	Homo sapiens	163-167
14656876-4	2004	In mice, deficiency of either HFE (Hfe(-/-)) or hepcidin (Usf2(-/-)) is associated with the same pattern of iron overload observed in patients with HH.	Iron	108-112	upstream transcription factor 2	Mus musculus	58-62
14656876-6	2004	Our results showed that, indeed, liver iron accumulation was greater in the Hfe(-/-)Usf2(+/-) mice than in mice lacking Hfe alone.	Iron	39-43	upstream transcription factor 2	Mus musculus	84-88
12760904-1	2003	Release of iron from enterocytes and hepatocytes is thought to require the copper-dependent ferroxidase activity of hephaestin (Hp) and ceruloplasmin (Cp), respectively.	Iron	11-15	ceruloplasmin	Rattus norvegicus	136-149
12921533-3	2003	Yeast with a deletion in FET3, which encodes a cell-surface multicopper oxidase, cannot grow on low-iron media.	Iron	100-104	ferroxidase FET3	Saccharomyces cerevisiae S288C	25-29
12921533-6	2003	Expression of hephaestin in Delta fet3 cells led to an increase in both iron transport and oxidase activity.	Iron	72-76	ferroxidase FET3	Saccharomyces cerevisiae S288C	34-38
14529289-0	2003	Flexible metal binding of the metallo-beta-lactamase domain: glyoxalase II incorporates iron, manganese, and zinc in vivo.	Iron	88-92	glyoxalase 2-1	Arabidopsis thaliana	61-74
14529289-2	2003	Within this protein family, glyoxalase II from Arabidopsis thaliana is the first member to be isolated with significant amounts of iron, manganese, and zinc when being recombinantly produced in Escherichia coli.	Iron	131-135	glyoxalase 2-1	Arabidopsis thaliana	28-41
12972614-1	2003	Iron regulatory protein 1 (IRP1) binds to mRNA iron-responsive elements (IREs) and thereby controls the expression of IRE-containing mRNAs.	Iron	47-51	aconitase 1	Homo sapiens	0-25
12972614-1	2003	Iron regulatory protein 1 (IRP1) binds to mRNA iron-responsive elements (IREs) and thereby controls the expression of IRE-containing mRNAs.	Iron	47-51	aconitase 1	Homo sapiens	27-31
12972614-2	2003	In iron-replete cells, assembly of a cubane [4Fe-4S] cluster inhibits IRE-binding activity and converts IRP1 to a cytosolic aconitase.	Iron	3-7	aconitase 1	Homo sapiens	104-108
12972614-10	2003	Furthermore, we demonstrate that the impairment of [4Fe-4S] cluster assembly in mammalian cells sensitizes IRP1(S138E) to iron-dependent degradation.	Iron	122-126	aconitase 1	Homo sapiens	107-111
12840010-8	2003	Expression of HmuO, the heme oxygenase from Corynebacterium diphtheriae, restores iron and heme levels, as well as Aft1p- and heme-dependent transcriptional activities, to those of wild type cells, indicating that the heme degradation activity associated with Hmx1p is important in mediating iron and heme homeostasis.	Iron	82-86	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	24-38
12840010-8	2003	Expression of HmuO, the heme oxygenase from Corynebacterium diphtheriae, restores iron and heme levels, as well as Aft1p- and heme-dependent transcriptional activities, to those of wild type cells, indicating that the heme degradation activity associated with Hmx1p is important in mediating iron and heme homeostasis.	Iron	292-296	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	24-38
12750164-0	2003	Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane.	Iron	0-4	natural resistance-associated macrophage protein 1	Cricetulus griseus	49-56
12915468-6	2003	We have detected two new HAMP mutations in two different families, in which there is concordance between severity of iron overload and heterozygosity for HAMP mutations when present with the HFE C282Y mutation.	Iron	117-121	homeostatic iron regulator	Homo sapiens	191-194
12928591-4	2003	Immunostaining demonstrated lower expression of MMP-9 in lesions of iron-restricted animals.	Iron	68-72	matrix metallopeptidase 9	Mus musculus	48-53
12927914-13	2003	The finding of HFE gene expression in rat hepatocytes raises interesting questions regarding its role in the hepatocyte iron metabolism.	Iron	120-124	homeostatic iron regulator	Rattus norvegicus	15-18
15086359-1	2004	BACKGROUND: Iron regulatory protein 1 (IRP1), a post-transcriptional regulator of iron metabolism, is activated in the duodenum of iron-deficient animals, which is associated with increased iron absorption.	Iron	82-86	aconitase 1	Rattus norvegicus	12-37
15086359-1	2004	BACKGROUND: Iron regulatory protein 1 (IRP1), a post-transcriptional regulator of iron metabolism, is activated in the duodenum of iron-deficient animals, which is associated with increased iron absorption.	Iron	82-86	aconitase 1	Rattus norvegicus	39-43
15086359-1	2004	BACKGROUND: Iron regulatory protein 1 (IRP1), a post-transcriptional regulator of iron metabolism, is activated in the duodenum of iron-deficient animals, which is associated with increased iron absorption.	Iron	131-135	aconitase 1	Rattus norvegicus	12-37
15086359-1	2004	BACKGROUND: Iron regulatory protein 1 (IRP1), a post-transcriptional regulator of iron metabolism, is activated in the duodenum of iron-deficient animals, which is associated with increased iron absorption.	Iron	131-135	aconitase 1	Rattus norvegicus	39-43
15086359-1	2004	BACKGROUND: Iron regulatory protein 1 (IRP1), a post-transcriptional regulator of iron metabolism, is activated in the duodenum of iron-deficient animals, which is associated with increased iron absorption.	Iron	131-135	aconitase 1	Rattus norvegicus	12-37
15086359-1	2004	BACKGROUND: Iron regulatory protein 1 (IRP1), a post-transcriptional regulator of iron metabolism, is activated in the duodenum of iron-deficient animals, which is associated with increased iron absorption.	Iron	131-135	aconitase 1	Rattus norvegicus	39-43
17916083-1	2007	BACKGROUND: Preterm infants are at risk of developing iron deficiency; among the iron status and hemopoiesis indices the serum transferrin receptor (sTfr) has been shown to be a useful indicator in assessing iron status, while immature reticulocyte production is regarded as an estimator of erythropoiesis.	Iron	54-58	transferrin receptor	Homo sapiens	127-147
15086359-2	2004	In cell cultures IRP1 was also activated by iron-independent signals, such as H(2)O(2).	Iron	44-48	aconitase 1	Rattus norvegicus	17-21
15086359-11	2004	In iron-deficiency, IRP activation correlates with increased (59)Fe absorption.	Iron	65-67	caspase 3	Rattus norvegicus	20-23
17916083-1	2007	BACKGROUND: Preterm infants are at risk of developing iron deficiency; among the iron status and hemopoiesis indices the serum transferrin receptor (sTfr) has been shown to be a useful indicator in assessing iron status, while immature reticulocyte production is regarded as an estimator of erythropoiesis.	Iron	81-85	transferrin receptor	Homo sapiens	127-147
17932563-0	2007	The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.	Iron	58-62	eukaryotic translation initiation factor 2A	Mus musculus	31-40
15013567-2	2004	Recent reports suggest that heterozygosity for the two common hfe mutations responsible for hereditary hemochromatosis (HH) may be a risk factor for AD, possibly by accelerating brain iron accumulation.	Iron	184-188	homeostatic iron regulator	Homo sapiens	62-65
15105251-1	2004	Cellular iron homeostasis is accomplished by the coordinated regulated expression of the transferrin receptor and ferritin, which mediate iron uptake and storage, respectively.	Iron	9-13	transferrin receptor	Homo sapiens	89-109
15105251-1	2004	Cellular iron homeostasis is accomplished by the coordinated regulated expression of the transferrin receptor and ferritin, which mediate iron uptake and storage, respectively.	Iron	138-142	transferrin receptor	Homo sapiens	89-109
15105251-4	2004	The IRE/IRP system also controls the expression of additional IRE-containing mRNAs, encoding proteins of iron and energy metabolism.	Iron	105-109	Wnt family member 2	Homo sapiens	8-11
15105251-5	2004	The activities of IRP1 and IRP2 are regulated by distinct posttranslational mechanisms in response to cellular iron levels.	Iron	111-115	aconitase 1	Homo sapiens	18-22
15105251-6	2004	Thus, in iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster, which prevents IRE binding, while IRP2 undergoes proteasomal degradation.	Iron	9-13	aconitase 1	Homo sapiens	29-33
15105251-6	2004	Thus, in iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster, which prevents IRE binding, while IRP2 undergoes proteasomal degradation.	Iron	53-57	aconitase 1	Homo sapiens	29-33
15105251-7	2004	IRP1 and IRP2 also respond, albeit differentially, to iron-independent signals, such as hydrogen peroxide, hypoxia, or nitric oxide.	Iron	54-58	aconitase 1	Homo sapiens	0-4
15105252-10	2004	Pharmacological blockage of the transferrin receptor/DMT1-mediated uptake could be a target to prevent further iron uptake.	Iron	111-115	transferrin receptor	Homo sapiens	32-52
17932563-4	2007	The level of production of hepcidin, an important player in the pathogenesis of the anemia of inflammation, was significantly decreased in Hri-/- mice, accompanied by decreased splenic macrophage iron content and increased serum iron content.	Iron	196-200	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	139-142
15009675-6	2004	Application of FAC to astrocyte cultures caused a strong increase in the cellular content of the iron storage protein ferritin and a decrease in the amount of transferrin receptor (TfR), which is involved in the transferrin-mediated uptake of iron into cells.	Iron	243-247	transferrin receptor	Rattus norvegicus	159-179
17932563-5	2007	Hepcidin expression was also significantly lower, with a concomitant increase in serum iron in Hri-/- mice upon LPS treatment.	Iron	87-91	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	95-98
15009675-6	2004	Application of FAC to astrocyte cultures caused a strong increase in the cellular content of the iron storage protein ferritin and a decrease in the amount of transferrin receptor (TfR), which is involved in the transferrin-mediated uptake of iron into cells.	Iron	243-247	transferrin receptor	Rattus norvegicus	181-184
17932563-6	2007	We also demonstrated an impairment of erythrophagocytosis by Hri-/- macrophages both in vitro and in vivo under chronic hemolytic anemia, providing evidence for the role of HRI in recycling iron from senescent red blood cells.	Iron	190-194	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	173-176
15024413-1	2004	Divalent metal transporter-1 (DMT1/DCT1/Nramp2) is the major Fe(2+) transporter mediating cellular iron uptake in mammals.	Iron	99-103	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-28
17932563-7	2007	This work demonstrates that HRI deficiency attenuates hepcidin expression and iron homeostasis in mice, indicating a potential role for HRI in the anemia of inflammation.	Iron	78-82	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	28-31
15024413-1	2004	Divalent metal transporter-1 (DMT1/DCT1/Nramp2) is the major Fe(2+) transporter mediating cellular iron uptake in mammals.	Iron	99-103	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	30-34
15024413-1	2004	Divalent metal transporter-1 (DMT1/DCT1/Nramp2) is the major Fe(2+) transporter mediating cellular iron uptake in mammals.	Iron	99-103	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	35-39
17949489-10	2007	The expression of transferrin receptor, heat shock protein 1B and DnaJ homolog B1 were down-regulated by iron in both muscle types.	Iron	105-109	transferrin receptor	Mus musculus	18-38
15024413-1	2004	Divalent metal transporter-1 (DMT1/DCT1/Nramp2) is the major Fe(2+) transporter mediating cellular iron uptake in mammals.	Iron	99-103	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	40-46
15024413-2	2004	Phenotypic analyses of animals with spontaneous mutations in DMT1 indicate that it functions at two distinct sites, transporting dietary iron across the apical membrane of intestinal absorptive cells, and transporting endosomal iron released from transferrin into the cytoplasm of erythroid precursors.	Iron	137-141	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	61-65
15024413-2	2004	Phenotypic analyses of animals with spontaneous mutations in DMT1 indicate that it functions at two distinct sites, transporting dietary iron across the apical membrane of intestinal absorptive cells, and transporting endosomal iron released from transferrin into the cytoplasm of erythroid precursors.	Iron	228-232	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	61-65
15024413-5	2004	This mutation severely impairs the iron transport capability of DMT1, leading to systemic iron deficiency and anemia.	Iron	35-39	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	64-68
17660359-0	2007	FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii.	Iron	145-149	uncharacterized protein	Chlamydomonas reinhardtii	128-132
17660359-1	2007	Previously, we had identified FOX1 and FTR1 as iron deficiency-inducible components of a high-affinity copper-dependent iron uptake pathway in Chlamydomonas.	Iron	47-51	uncharacterized protein	Chlamydomonas reinhardtii	30-34
17660359-1	2007	Previously, we had identified FOX1 and FTR1 as iron deficiency-inducible components of a high-affinity copper-dependent iron uptake pathway in Chlamydomonas.	Iron	120-124	uncharacterized protein	Chlamydomonas reinhardtii	30-34
15287192-11	2004	CONCLUSION: We propose that CYP2E1 activation occurs possibly due to OH* and contributes to H2O2-mediated LLC-PK1 cell necrosis by acting as a source of iron and perpetuating the generation of OH* via the Fenton reaction.	Iron	153-157	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	28-34
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	83-87	uncharacterized protein	Chlamydomonas reinhardtii	65-69
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	65-69
18551934-7	2007	However, five patients in the iron repleted RA sub group had an elevated sTfR level, of which two had increased TfR-F index.	Iron	30-34	transferrin receptor	Homo sapiens	74-77
15272264-5	2004	HH is caused by inappropriate absorption of dietary iron, typically as the result of a specific mutation, C282Y, in the HFE gene.	Iron	52-56	homeostatic iron regulator	Homo sapiens	120-123
14535549-2	2003	Transferrin is an iron-binding protein that has bacteriostatic properties in the blood.	Iron	18-22	inhibitor of carbonic anhydrase	Equus caballus	0-11
14720453-1	2004	Hereditary hemochromatosis is a common autosomal- recessive disorder of iron overload usually occurring in individuals who are homozygous for a C282Y mutation in the hemochromatosis (HFE) gene.	Iron	72-76	homeostatic iron regulator	Homo sapiens	183-186
17551831-3	2007	DHA caused a nearly 10-fold increase in free iron uptake in NGF-treated cells and doubled iron uptake in nondifferentiated cells.	Iron	45-49	nerve growth factor	Rattus norvegicus	60-63
14724150-0	2004	Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.	Iron	92-96	hephaestin	Mus musculus	19-29
14724150-1	2004	BACKGROUND: Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes.	Iron	90-94	hephaestin	Mus musculus	12-22
14724150-2	2004	Sex linked anaemia (sla) mice have a defect in the release of iron from intestinal enterocytes into the circulation due to an interstitial deletion in the hephaestin gene (heph).	Iron	62-66	hephaestin	Mus musculus	155-165
12874382-0	2003	Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.	Iron	40-44	homeostatic iron regulator	Homo sapiens	14-17
12874382-0	2003	Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.	Iron	40-44	homeostatic iron regulator	Homo sapiens	81-84
12874382-1	2003	The mechanisms by which the hereditary hemochromatosis protein, HFE, decreases transferrin-mediated iron uptake were examined.	Iron	100-104	homeostatic iron regulator	Homo sapiens	64-67
12874382-4	2003	However, cells expressing HFE still showed a decrease in Tf-mediated iron uptake at concentrations of Tf sufficient to dissociate HFE from the TfR.	Iron	69-73	homeostatic iron regulator	Homo sapiens	26-29
12874382-7	2003	HeLa cells expressing fW81AHFE behaved in a similar manner to cells expressing wild-type HFE with respect to decreased intracellular iron levels measured by iron regulatory protein gel-shift assays and ferritin levels.	Iron	133-137	homeostatic iron regulator	Homo sapiens	27-30
12874382-7	2003	HeLa cells expressing fW81AHFE behaved in a similar manner to cells expressing wild-type HFE with respect to decreased intracellular iron levels measured by iron regulatory protein gel-shift assays and ferritin levels.	Iron	157-161	homeostatic iron regulator	Homo sapiens	27-30
12874382-8	2003	The results indicate that HFE can lower intracellular iron levels independently of its interaction with the TfR.	Iron	54-58	homeostatic iron regulator	Homo sapiens	26-29
14643898-1	2004	To secure iron from transferrin, hepatocytes use two pathways, one dependent on transferrin receptor (TfR 1) and the other, of greater capacity but lower affinity, independent of TfR 1.	Iron	10-14	transferrin receptor	Homo sapiens	80-100
17895834-2	2007	The aim of this study was to investigate the effects in the pancreas on gene expressions of metallothionein 1 (MT1), divalent metal transporter 1 (DMT1), and zinc transporter 5 (ZnT-5) and concomitant changes in iron (Fe), copper (Cu), and zinc (Zn) in serum and pancreas of Balb/c mice on days 3, 6, and 9 of CVB3 infection.	Iron	212-216	solute carrier family 30 (zinc transporter), member 5	Mus musculus	178-183
14770366-2	2004	The classical view of iron metabolism has been challenged over the past ten years by the discovery of several new proteins, mostly Fe (II) iron transporters, enzymes with ferro-oxydase (hephaestin or ceruloplasmin) or ferri-reductase (Dcytb) activity or regulatory proteins like HFE and hepcidin.	Iron	22-26	homeostatic iron regulator	Homo sapiens	279-282
17895834-2	2007	The aim of this study was to investigate the effects in the pancreas on gene expressions of metallothionein 1 (MT1), divalent metal transporter 1 (DMT1), and zinc transporter 5 (ZnT-5) and concomitant changes in iron (Fe), copper (Cu), and zinc (Zn) in serum and pancreas of Balb/c mice on days 3, 6, and 9 of CVB3 infection.	Iron	218-220	solute carrier family 30 (zinc transporter), member 5	Mus musculus	178-183
14770366-12	2004	Hepcidin synthesis in response to iron overload seems to be controlled by the HFE molecule.	Iron	34-38	homeostatic iron regulator	Homo sapiens	78-81
12663437-5	2003	Recent evidence shows that deficient hepcidin response to iron loading may contribute to iron overload even in the much milder common form of hemochromatosis, from mutations in the HFE gene.	Iron	58-62	homeostatic iron regulator	Homo sapiens	181-184
12663437-5	2003	Recent evidence shows that deficient hepcidin response to iron loading may contribute to iron overload even in the much milder common form of hemochromatosis, from mutations in the HFE gene.	Iron	89-93	homeostatic iron regulator	Homo sapiens	181-184
14770366-13	2004	Patients with hereditary hemochromatosis due to HFE mutation have impaired hepcidin synthesis and forced expression of an hepcidin transgene in HFE deficient mice prevents iron overload.	Iron	172-176	homeostatic iron regulator	Homo sapiens	144-147
17937914-0	2007	Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.	Iron	76-80	iron-sulfur cluster assembly protein CIA1	Saccharomyces cerevisiae S288C	43-47
14514697-1	2003	Atm1 is an ABC transporter that is located in yeast mitochondria and has previously been implicated in the maturation of cytosolic iron-sulfur cluster proteins.	Iron	131-135	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	0-4
17937914-1	2007	The WD40-repeat protein Cia1 is an essential, conserved member of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery in eukaryotes.	Iron	80-84	iron-sulfur cluster assembly protein CIA1	Saccharomyces cerevisiae S288C	24-28
17767550-11	2007	This study suggests for the first time that a differential expression of MCP-1 protein in patients with HH is associated with the specific HFE genetic component for iron overload.	Iron	165-169	homeostatic iron regulator	Homo sapiens	139-142
14664603-3	2003	Finally, the known heterodinuclear species [(Me3[9]aneN3)CrIII(mu-O)(mu-CH3CO2)2Fe([9]aneN3)](PF6)2 (5(PF6)(2)) can also be one-electron oxidized yielding [5ox]3+ containing an iron(IV) ion.	Iron	177-181	sperm associated antigen 17	Homo sapiens	94-97
12948285-1	2003	BACKGROUND &amp; AIMS: Heterozygosity for the Cys282Tyr transition in the HFE-gene is associated with slightly increased iron levels and may therefore be a potential risk factor for colorectal cancer.	Iron	121-125	homeostatic iron regulator	Homo sapiens	74-77
12875842-1	2003	The yeast ATM1 gene is essential for normal cellular iron homeostasis.	Iron	53-57	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	10-14
17475336-12	2007	These data indicate that multiple pathways are involved in the underlying mechanisms of MPP+-induced neurotoxicity, including apoptosis, oxidative stress, iron binding, cellular metabolism, and signal transduction.	Iron	155-159	M-phase phosphoprotein 6	Homo sapiens	88-91
12875842-2	2003	Deletion of ATM1 results in mitochondrial iron accumulation and increased sensitivity to oxidative stress and transition metal toxicity.	Iron	42-46	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	12-16
14580148-2	2003	Heme degradation is catalyzed by the two isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, eventually yielding biliverdin/bilirubin, CO, and iron.	Iron	153-157	heme oxygenase 2	Homo sapiens	97-101
14668040-1	2003	We sought to establish the relationship of quantitative hepatic iron measurements and phlebotomy-mobilized iron in a large sample of HFE C282Y homozygotes with a hemochromatosis phenotype.	Iron	64-68	homeostatic iron regulator	Homo sapiens	133-136
14668040-1	2003	We sought to establish the relationship of quantitative hepatic iron measurements and phlebotomy-mobilized iron in a large sample of HFE C282Y homozygotes with a hemochromatosis phenotype.	Iron	107-111	homeostatic iron regulator	Homo sapiens	133-136
14557859-0	2003	Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype.	Iron	94-98	transferrin receptor	Homo sapiens	20-40
14557859-5	2003	In HCV-infected patients, heterozygosity for the C282Y mutation in HFE was significantly associated with elevated serum ferritin levels, stainable liver iron, and advanced fibrosis or cirrhosis (F2-F4).	Iron	153-157	homeostatic iron regulator	Homo sapiens	67-70
14557859-7	2003	Heterozygosity for the C282Y mutation in HFE contributes to iron accumulation and fibrosis progression in chronic hepatitis C.	Iron	60-64	homeostatic iron regulator	Homo sapiens	41-44
12844390-0	2003	Iron deficiency and in vitro iron chelation reduce the expression of cluster of differentiation molecule (CD)28 but not CD3 receptors on murine thymocytes and spleen cells.	Iron	29-33	CD3 antigen, epsilon polypeptide	Mus musculus	120-123
12844390-11	2003	Indicators of Fe status negatively correlated with CD3 FI (r-0.23), but positively correlated with CD28 FI (r&lt; or =0.44; P&lt;0.05).	Iron	14-16	CD3 antigen, epsilon polypeptide	Mus musculus	51-54
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	184-188	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	46-53
14675444-10	2003	Sequences homologous to IDE1 were also found in many other Fe-deficiency-inducible promoters, including: nicotianamine aminotransferase (HvNAAT)-A, HvNAAT-B, nicotianamine synthase (HvNAS1), HvIDS3, OsNAS1, OsNAS2, OsIRT1, AtIRT1, and AtFRO2, suggesting the conservation of cis-acting elements in various genes and species.	Iron	59-61	ferric reduction oxidase 2	Arabidopsis thaliana	235-241
14691533-1	2003	Transferrin receptor 1 (TfR) plays a critical role in cellular iron import for most higher organisms.	Iron	63-67	transferrin receptor	Homo sapiens	0-22
14691533-1	2003	Transferrin receptor 1 (TfR) plays a critical role in cellular iron import for most higher organisms.	Iron	63-67	transferrin receptor	Homo sapiens	24-27
17604281-1	2007	Iron regulatory proteins (IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	0-4	aconitase 1	Homo sapiens	26-30
14691533-2	2003	Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process.	Iron	38-42	transferrin receptor	Homo sapiens	13-16
14691533-2	2003	Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process.	Iron	131-135	transferrin receptor	Homo sapiens	13-16
14691533-2	2003	Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process.	Iron	131-135	transferrin receptor	Homo sapiens	177-180
14691533-3	2003	The iron-free form of Tf (apo-Tf) remains bound to TfR and is recycled to the cell surface, where the complex dissociates upon exposure to the slightly basic pH of the blood.	Iron	4-8	transferrin receptor	Homo sapiens	51-54
14691533-4	2003	Fe-Tf competes for binding to TfR with HFE, the protein mutated in the iron-overload disease hereditary hemochromatosis.	Iron	0-2	transferrin receptor	Homo sapiens	30-33
14691533-4	2003	Fe-Tf competes for binding to TfR with HFE, the protein mutated in the iron-overload disease hereditary hemochromatosis.	Iron	0-2	homeostatic iron regulator	Homo sapiens	39-42
12942784-1	2003	Expression of hereditary hemochromatosis as well as predisposition to iron overload syndrome and sporadic porphyria cutanea tarda are currently believed to be associated with the inheritance of certain allelic variants of the HFE gene.	Iron	70-74	homeostatic iron regulator	Homo sapiens	226-229
17003017-1	2003	There are a few reports suggesting that subtle disturbances of iron metabolism are frequently found in patients with type 2 diabetes (DM2), but it is not known if these disturbances precede or accompany the diabetic state.	Iron	63-67	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	134-137
14691533-5	2003	We used a quantitative surface plasmon resonance assay to determine the binding affinities of an extensive set of site-directed TfR mutants to HFE and Fe-Tf at pH 7.4 and to apo-Tf at pH 6.3.	Iron	151-153	transferrin receptor	Homo sapiens	128-131
17604281-1	2007	Iron regulatory proteins (IRP1 and IRP2) are master regulators of cellular iron metabolism.	Iron	75-79	aconitase 1	Homo sapiens	26-30
17604281-8	2007	Even though the knockdown of IRP-1, IRP-2, or both was efficient, resulting in nondetectable protein and under 5% of wild type levels of mRNA, all stable knockdowns retained an ability to modulate ferritin H and TfR1 appropriately in response to iron challenge.	Iron	246-250	aconitase 1	Homo sapiens	29-34
12684851-9	2003	For the Fet3p(E185D) mutant, K(M) for iron was 300-fold greater than the wild-type K(M), while Fet3p(E185A) was completely inactive in support of iron uptake.	Iron	38-42	ferroxidase FET3	Saccharomyces cerevisiae S288C	8-13
17604281-9	2007	However, further knockdown of IRPs accomplished by transient transfection of small interfering RNA in stable knockdown cells completely abolished the response of ferritin H and TfR1 to iron challenge, demonstrating an extensive excess capacity of the IRP system.	Iron	185-189	transferrin receptor	Homo sapiens	177-181
12684851-9	2003	For the Fet3p(E185D) mutant, K(M) for iron was 300-fold greater than the wild-type K(M), while Fet3p(E185A) was completely inactive in support of iron uptake.	Iron	146-150	ferroxidase FET3	Saccharomyces cerevisiae S288C	8-13
17604281-9	2007	However, further knockdown of IRPs accomplished by transient transfection of small interfering RNA in stable knockdown cells completely abolished the response of ferritin H and TfR1 to iron challenge, demonstrating an extensive excess capacity of the IRP system.	Iron	185-189	Wnt family member 2	Homo sapiens	30-33
14623077-14	2003	Further studies showed that PFKFB-1 and PFKFB-2 were highly responsive to hypoxia mimics such as transition metals, iron chelators and inhibitors of HIF hydroxylases, suggesting that the hypoxia responsiveness of these genes is also regulated by HIF proteins.	Iron	116-120	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Mus musculus	28-35
17721086-8	2007	Iron-depletion also leads to proteasomal degradation of p21(CIP1/WAF1) and cyclin D1 via an ubiquitin-independent pathway.	Iron	0-4	cyclin D1	Homo sapiens	75-84
12931885-2	2003	Corrosion of Fe(0) filings and the formation of precipitates can occur when the PRB material comes in contact with ground water and may reduce the lifespan and effectiveness of the barrier.	Iron	13-18	RB transcriptional corepressor 1	Homo sapiens	80-83
17653382-0	2007	An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir.	Iron	3-7	neuraminidase 1	Homo sapiens	43-56
12931885-9	2003	Maghemite/magnetite content increased over time and in oven-dried samples, especially after heating to 105 degrees C. We conclude that care must be taken during sample preparation of Fe(0) PRB material, especially for detection of green rusts, to ensure accurate identification of minerals present within the barrier system.	Iron	183-188	RB transcriptional corepressor 1	Homo sapiens	189-192
12783844-2	2003	Whether the common HFE mutations, that associate with this condition and pre-dispose to increases in serum iron indices, are over-represented in diabetic populations remains controversial.	Iron	107-111	homeostatic iron regulator	Homo sapiens	19-22
14562166-1	2003	INTRODUCTION: Heme oxygenase (HO) isoforms, HO-1, and HO-2, are responsible for heme breakdown to iron and carbon monoxide (CO).	Iron	98-102	heme oxygenase 2	Homo sapiens	54-58
14765621-1	2003	BACKGROUND: Mutations in the HFE gene have been shown to be strongly associated with hereditary haemochromatosis, an autosomal recessive disease of iron overloading.	Iron	148-152	homeostatic iron regulator	Homo sapiens	29-32
14765621-9	2003	Although the HFE mutations were increased among patients of thalassaemia their effect on iron burden or disease pathogenesis remains unclear.	Iron	89-93	homeostatic iron regulator	Homo sapiens	13-16
17651435-2	2007	Frataxin, which has been highly conserved throughout evolution, is thought to be involved in, among other processes, Fe-S cluster formation.	Iron	117-121	frataxin	Homo sapiens	0-8
12915401-1	2003	Increasing evidence suggests that iron-mediated oxidative stress might underlie the development of neurodegeneration in Friedreich"s ataxia (FRDA), an autosomal recessive ataxia caused by decreased expression of frataxin, a protein implicated in iron metabolism.	Iron	34-38	frataxin	Homo sapiens	141-145
12915401-1	2003	Increasing evidence suggests that iron-mediated oxidative stress might underlie the development of neurodegeneration in Friedreich"s ataxia (FRDA), an autosomal recessive ataxia caused by decreased expression of frataxin, a protein implicated in iron metabolism.	Iron	34-38	frataxin	Homo sapiens	212-220
12915401-1	2003	Increasing evidence suggests that iron-mediated oxidative stress might underlie the development of neurodegeneration in Friedreich"s ataxia (FRDA), an autosomal recessive ataxia caused by decreased expression of frataxin, a protein implicated in iron metabolism.	Iron	246-250	frataxin	Homo sapiens	141-145
12576298-2	2003	One potential candidate for such transferrin-independent uptake of iron is divalent metal transporter-1 (DMT1), an established iron transporter.	Iron	67-71	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	105-109
12576298-2	2003	One potential candidate for such transferrin-independent uptake of iron is divalent metal transporter-1 (DMT1), an established iron transporter.	Iron	67-71	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	75-103
12576298-3	2003	We tested the hypothesis that increased concentrations of iron in the lungs of Hp mice are associated with elevations in DMT1 expression.	Iron	58-62	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	121-125
12576298-5	2003	Western blot analyses for the expression of two isoforms of DMT1 in the Hp mice relative to the wild-type animals demonstrated an elevation for the isoform that lacks an iron-responsive element (IRE) with significant decrements in the expression of +IRE DMT1.	Iron	170-174	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	60-64
12576298-10	2003	We conclude that differences between Hp and wild-type mice in nonheme iron concentrations were accompanied by increases in the expression of -IRE DMT1.	Iron	70-74	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	146-150
12915401-1	2003	Increasing evidence suggests that iron-mediated oxidative stress might underlie the development of neurodegeneration in Friedreich"s ataxia (FRDA), an autosomal recessive ataxia caused by decreased expression of frataxin, a protein implicated in iron metabolism.	Iron	246-250	frataxin	Homo sapiens	212-220
17658866-1	2007	Novel coaxial structures consisting of nitrogen-doped carbon nanotube (MWNTs-CNx) cores with external concentric shells of pure carbon were produced by the pyrolysis of toluene over Fe-coated MWNTs-CNx.	Iron	182-184	calnexin	Homo sapiens	77-80
12888561-5	2003	By employing this model we show that HOCl prevents the H2O2-mediated activation of iron regulatory protein 1 (IRP1), a central post-transcriptional regulator of mammalian iron metabolism.	Iron	83-87	aconitase 1	Homo sapiens	110-114
12888561-6	2003	Activated IRP1 binds to (R)iron-responsive elements" (IREs) within the mRNAs encoding proteins of iron metabolism and thereby controls their translation or stability.	Iron	27-31	aconitase 1	Homo sapiens	10-14
12888561-6	2003	Activated IRP1 binds to (R)iron-responsive elements" (IREs) within the mRNAs encoding proteins of iron metabolism and thereby controls their translation or stability.	Iron	98-102	aconitase 1	Homo sapiens	10-14
12792703-1	2003	The hypothesis of the role of iron overload associated with HFE gene mutations in the pathogenesis of nonalcoholic steatohepatitis (NASH) has been raised in recent years.	Iron	30-34	homeostatic iron regulator	Homo sapiens	60-63
14512884-2	2003	At transferrin (Tf) concentrations of 50 nmol/L and 5 micromol/L, when Tf-Fe uptake occurs by the TfR1- and TfR1-independent (NTfR1)-mediated process, respectively, the rate of Fe uptake by proliferating cells was approximately 250% that of stationary cells.	Iron	74-76	transferrin receptor	Homo sapiens	98-102
17658866-1	2007	Novel coaxial structures consisting of nitrogen-doped carbon nanotube (MWNTs-CNx) cores with external concentric shells of pure carbon were produced by the pyrolysis of toluene over Fe-coated MWNTs-CNx.	Iron	182-184	calnexin	Homo sapiens	198-201
14512884-2	2003	At transferrin (Tf) concentrations of 50 nmol/L and 5 micromol/L, when Tf-Fe uptake occurs by the TfR1- and TfR1-independent (NTfR1)-mediated process, respectively, the rate of Fe uptake by proliferating cells was approximately 250% that of stationary cells.	Iron	74-76	transferrin receptor	Homo sapiens	108-112
14512884-2	2003	At transferrin (Tf) concentrations of 50 nmol/L and 5 micromol/L, when Tf-Fe uptake occurs by the TfR1- and TfR1-independent (NTfR1)-mediated process, respectively, the rate of Fe uptake by proliferating cells was approximately 250% that of stationary cells.	Iron	177-179	transferrin receptor	Homo sapiens	98-102
17656326-6	2007	The yeast protein Atm1p plays a critical role in the transport of Fe/S clusters to the cytosol, and a similar function has been attributed to the homologous human proteins MTABC3 and ABC7.	Iron	66-68	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	18-23
14512884-2	2003	At transferrin (Tf) concentrations of 50 nmol/L and 5 micromol/L, when Tf-Fe uptake occurs by the TfR1- and TfR1-independent (NTfR1)-mediated process, respectively, the rate of Fe uptake by proliferating cells was approximately 250% that of stationary cells.	Iron	177-179	transferrin receptor	Homo sapiens	108-112
14512884-3	2003	The maximum rate of Fe uptake by the TfR1- and NTfR1-mediated process by proliferating cells was increased to 200% and 300% that of stationary cells, respectively.	Iron	20-22	transferrin receptor	Homo sapiens	37-41
14512884-7	2003	In conclusion, an increase in Tf-Fe uptake by TfR1-mediated pathway by proliferating cells was associated with increased TfR1 mRNA and protein expression.	Iron	33-35	transferrin receptor	Homo sapiens	46-50
14512884-7	2003	In conclusion, an increase in Tf-Fe uptake by TfR1-mediated pathway by proliferating cells was associated with increased TfR1 mRNA and protein expression.	Iron	33-35	transferrin receptor	Homo sapiens	121-125
17656326-6	2007	The yeast protein Atm1p plays a critical role in the transport of Fe/S clusters to the cytosol, and a similar function has been attributed to the homologous human proteins MTABC3 and ABC7.	Iron	66-68	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	172-178
17543888-1	2007	Hereditary Hemochromatosis is an iron overload disease most frequently associated with mutations in the HFE gene.	Iron	33-37	homeostatic iron regulator	Homo sapiens	104-107
14507405-7	2003	The mucin was highlighted by alcian blue and colloidal iron stains, and it was negative with mucicarmine and periodic acid-Schiff stains.	Iron	55-59	LOC100508689	Homo sapiens	4-9
17650303-1	2007	BACKGROUND: Hereditary Hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele are at risk for the development of a range of disorders particularly liver disease.	Iron	81-85	homeostatic iron regulator	Homo sapiens	149-152
14619590-7	2003	CONCLUSION: The possible mechanism by which rhEPO increased the positive cell rate of iron stain might be due to the enhancement of TfR expression and hence the increase in iron intake of K562 cells.	Iron	86-90	transferrin receptor	Homo sapiens	132-135
17579400-4	2007	As the first well-characterized iron complex of an ascorbic acid H(2)AA analogue, 1 provides insight into the possible coordination geometry of the family of complexes containing H(2)AA and its analogues.	Iron	32-36	H2A clustered histone 8	Homo sapiens	65-71
12832419-6	2003	Rodent and human cell lines cultured in the presence of the specific copper chelator 2,3,2-tetraamine displayed a dose-dependent increase in CCS protein that could be reversed with the addition of copper but not iron or zinc to the cells.	Iron	212-216	copper chaperone for superoxide dismutase	Homo sapiens	141-144
12730111-1	2003	Hephaestin is a membrane-bound multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation.	Iron	69-73	hephaestin	Mus musculus	0-10
17579400-4	2007	As the first well-characterized iron complex of an ascorbic acid H(2)AA analogue, 1 provides insight into the possible coordination geometry of the family of complexes containing H(2)AA and its analogues.	Iron	32-36	H2A clustered histone 8	Homo sapiens	179-185
12730111-2	2003	Mice with sex-linked anemia (sla) have a mutant form of Hephaestin and a defect in intestinal basolateral iron transport, which results in iron deficiency and anemia.	Iron	106-110	hephaestin	Mus musculus	29-32
12730111-4	2003	We compared iron levels and expression of genes involved in iron uptake and storage in sla mice and C57BL/6J mice fed iron-deficient, iron-overload, or control diets.	Iron	60-64	hephaestin	Mus musculus	87-90
17468165-5	2007	Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.	Iron	139-143	neuroglobin	Mus musculus	93-96
12730111-4	2003	We compared iron levels and expression of genes involved in iron uptake and storage in sla mice and C57BL/6J mice fed iron-deficient, iron-overload, or control diets.	Iron	60-64	hephaestin	Mus musculus	87-90
12730111-4	2003	We compared iron levels and expression of genes involved in iron uptake and storage in sla mice and C57BL/6J mice fed iron-deficient, iron-overload, or control diets.	Iron	60-64	hephaestin	Mus musculus	87-90
12730111-5	2003	Both iron-deficient wild-type mice and sla mice showed increased expression of Heph and Ireg1 mRNA, compared to controls, whereas only iron-deficient wild-type mice had increased expression of the brush border transporter Dmt1.	Iron	5-9	hephaestin	Mus musculus	79-83
12730111-5	2003	Both iron-deficient wild-type mice and sla mice showed increased expression of Heph and Ireg1 mRNA, compared to controls, whereas only iron-deficient wild-type mice had increased expression of the brush border transporter Dmt1.	Iron	5-9	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	222-226
12730111-6	2003	Unlike iron-deficient mice, sla mouse enterocytes accumulated nonheme iron and ferritin.	Iron	70-74	hephaestin	Mus musculus	28-31
17468165-5	2007	Oxygen, nitric oxide, or carbon monoxide can displace the distal histidine which, in ferrous Ngb as well as in ferric Ngb, is bound to the iron, yielding a reversible adduct.	Iron	139-143	neuroglobin	Mus musculus	118-121
12730111-7	2003	These results indicate that Dmt1 can be modulated by the enterocyte iron level, whereas Hephaestin and Ireg1 expression respond to systemic rather than local signals of iron status.	Iron	68-72	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	28-32
17616764-0	2007	Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life.	Iron	108-112	transferrin receptor	Homo sapiens	47-67
12949720-8	2003	This points to different kinetics of intestinal iron uptake between iron deficiency and HFE hemochromatosis and also indicates that duodenal iron accumulation in HFE and non-HFE hemochromatosis is pathophysiologically different.	Iron	48-52	homeostatic iron regulator	Homo sapiens	88-91
14692443-2	2003	In the vast majority of the cases, the hereditary iron overload is caused by mutations in the HFE gene.	Iron	50-54	homeostatic iron regulator	Homo sapiens	94-97
17560653-12	2007	Low Fe supplemental treatment suppressed the phosphorylation of ERK1/2 and JNK1/2 but not Elk-1.	Iron	4-6	mitogen activated protein kinase 3	Rattus norvegicus	64-70
12969425-5	2003	Together with the observation that Mg-porphyrin accumulation in dark-grown seedlings treated with an iron chelator was unaffected by BVR expression, these results indicate that BVR diverts tetrapyrrole metabolism toward heme synthesis while also reducing heme levels to de-repress ALA synthesis.	Iron	101-105	biliverdin reductase A	Homo sapiens	177-180
17560653-13	2007	Interestingly, high Fe treatment slightly suppressed the phosphorylation of JNK1/2, but significantly elevated the phosphorylation of ERK1/2 and Elk-1.	Iron	20-22	mitogen activated protein kinase 3	Rattus norvegicus	134-140
17560653-13	2007	Interestingly, high Fe treatment slightly suppressed the phosphorylation of JNK1/2, but significantly elevated the phosphorylation of ERK1/2 and Elk-1.	Iron	20-22	ETS transcription factor ELK1	Rattus norvegicus	145-150
13129684-1	2003	Transport of iron from the mother to the fetus is essential for the normal development of the fetus and abnormalities in the transferrin receptor (TFR) on the placental trophoblasts might have some crucial effects on the fetal iron metabolism.	Iron	13-17	transferrin receptor	Homo sapiens	125-145
17391316-9	2007	Iron depletion was more effective in reducing HOMA-R in patients in the top two tertiles of ferritin concentrations (P&lt;0.05 vs controls), and in carriers of the mutations in the HFE gene of hereditary hemochromatosis (P&lt;0.05 vs noncarriers).	Iron	0-4	homeostatic iron regulator	Homo sapiens	181-184
13129684-1	2003	Transport of iron from the mother to the fetus is essential for the normal development of the fetus and abnormalities in the transferrin receptor (TFR) on the placental trophoblasts might have some crucial effects on the fetal iron metabolism.	Iron	13-17	transferrin receptor	Homo sapiens	147-150
13129684-1	2003	Transport of iron from the mother to the fetus is essential for the normal development of the fetus and abnormalities in the transferrin receptor (TFR) on the placental trophoblasts might have some crucial effects on the fetal iron metabolism.	Iron	227-231	transferrin receptor	Homo sapiens	125-145
13129684-1	2003	Transport of iron from the mother to the fetus is essential for the normal development of the fetus and abnormalities in the transferrin receptor (TFR) on the placental trophoblasts might have some crucial effects on the fetal iron metabolism.	Iron	227-231	transferrin receptor	Homo sapiens	147-150
17205209-3	2007	Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1).	Iron	28-32	aconitase 1	Homo sapiens	288-292
14653404-4	2003	It is now clear that the unstable GAA expansion that underlies FA causes a deficiency of the mitochondrial protein frataxin, leading to potentially harmful oxidative injury associated with excessive iron deposits in mitochondria.	Iron	199-203	frataxin	Homo sapiens	115-123
17205209-3	2007	Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1).	Iron	186-190	aconitase 1	Homo sapiens	288-292
17521334-0	2007	Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis.	Iron	17-21	aconitase 1	Homo sapiens	41-66
12886008-9	2003	These results, together with previous reports of subcellular distributions of isoforms of human IscS and IscU in mitochondria, cytosol, and nucleus suggest that the Fe-S cluster assembly machineries are compartmentalized in higher eukaryotes.	Iron	165-169	NFS1 cysteine desulfurase	Homo sapiens	96-100
12885946-3	2003	Addition of iron before cytokine stimulation resulted in a dose-dependent reduction of these pathways, and iron restriction by desferrioxamine (DFO) enhanced ICAM-1, HLA-DR, and GTP-CH expression.	Iron	107-111	GTP cyclohydrolase 1	Homo sapiens	178-184
17521334-1	2007	Iron regulatory protein-1 binding to the iron-responsive element of mRNA is sensitive to iron, oxidative stress, NO, and hypoxia.	Iron	41-45	aconitase 1	Homo sapiens	0-25
12885946-5	2003	IFN-gamma-inducible mRNA expression of ICAM-1, HLA-DR, and GTP-CH was reduced by iron and increased by DFO by a transcriptional mechanism.	Iron	81-85	GTP cyclohydrolase 1	Homo sapiens	59-65
17521334-1	2007	Iron regulatory protein-1 binding to the iron-responsive element of mRNA is sensitive to iron, oxidative stress, NO, and hypoxia.	Iron	89-93	aconitase 1	Homo sapiens	0-25
12885946-6	2003	Moreover, ICAM-1 and to a lesser extent, GTP-CH and HLA-DR mRNA expression were regulated post-transcriptionally, as iron pretreatment resulted in shortening the mRNA half-life compared with cells treated with IFN-gamma alone.	Iron	117-121	GTP cyclohydrolase 1	Homo sapiens	41-47
17475338-6	2007	The iron K-edge from unaffected HMFs were best fitted with poorly organized ferrihydrite modeled by frataxin whereas HMFs from affected cells were best fitted with highly organized ferrihydrite modeled by ferritin.	Iron	4-8	frataxin	Homo sapiens	100-108
12837693-2	2003	Five hypotheses for frataxin"s mitochondrial function have been generated, largely from work in non-human cells: iron transporter, iron-sulfur cluster assembler, iron-storage protein, antioxidant and stimulator of oxidative phosphorylation.	Iron	113-117	frataxin	Homo sapiens	20-28
12837693-2	2003	Five hypotheses for frataxin"s mitochondrial function have been generated, largely from work in non-human cells: iron transporter, iron-sulfur cluster assembler, iron-storage protein, antioxidant and stimulator of oxidative phosphorylation.	Iron	131-135	frataxin	Homo sapiens	20-28
17475338-8	2007	Since the iron K-edge spectra of ferritin and frataxin are very similar, we present additional evidence for the presence of ferritin-bound iron in HMF.	Iron	139-143	frataxin	Homo sapiens	46-54
17374500-9	2007	These findings indicate that the lack of tRNA pseudouridylation can be overcome by compensatory changes in levels of ribosomal proteins, and that the disease phenotype in affected tissues is likely due to pleiotropic effects of PUS1p on non-tRNA molecules involved in DNA transcription and iron metabolism.	Iron	290-294	pseudouridine synthase 1	Homo sapiens	228-233
12709425-5	2003	We isolated Lenramp1 and Lenramp3 from tomato and demonstrate that these genes encode functional NRAMP metal transporters in yeast, where they were iron-regulated and localized mainly to intracellular vesicles.	Iron	148-152	metal transporter	Solanum lycopersicum	25-33
12791823-1	2003	UNLABELLED: Recent studies have revealed that the wild-type hemochromatosis protein (HFE) interacts with the transferrin receptor (TfR) and modulates TfR-mediated iron uptake by cells.	Iron	163-167	homeostatic iron regulator	Homo sapiens	85-88
17264297-2	2007	Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells.	Iron	206-210	transferrin receptor	Mus musculus	174-178
12791823-1	2003	UNLABELLED: Recent studies have revealed that the wild-type hemochromatosis protein (HFE) interacts with the transferrin receptor (TfR) and modulates TfR-mediated iron uptake by cells.	Iron	163-167	transferrin receptor	Homo sapiens	109-129
12791823-1	2003	UNLABELLED: Recent studies have revealed that the wild-type hemochromatosis protein (HFE) interacts with the transferrin receptor (TfR) and modulates TfR-mediated iron uptake by cells.	Iron	163-167	transferrin receptor	Homo sapiens	150-153
12941522-0	2003	Over-expression of wild-type and mutant HFE in a human melanocytic cell line reveals an intracellular bridge between MHC class I pathway and transferrin iron uptake.	Iron	153-157	homeostatic iron regulator	Homo sapiens	40-43
17495406-2	2007	The voltammetric results can be explained well by a theoretical equation for the so-called IT-mechanism, in which a homogeneous ET reaction between [Fe(C(5)H(5))2] (partially distributed from 1,2-DCE) and [Fe(CN)6](3-) takes place in the W phase and the resultant [Fe(C(5)H(5))2]+ ion is responsible for current passage across the interface.	Iron	149-151	24-dehydrocholesterol reductase	Homo sapiens	196-199
12813369-3	2003	Mice deleted in the hfe gene (hfe-/-) abnormally accumulate iron in tissue; defects in the human hfe gene are clinically expressed as hemochromatosis.	Iron	60-64	homeostatic iron regulator	Homo sapiens	30-33
12805609-1	2003	Regulation of the root high-affinity iron uptake system by whole-plant signals was investigated at the molecular level in Arabidopsis, through monitoring FRO2 and IRT1 gene expression.	Iron	37-41	ferric reduction oxidase 2	Arabidopsis thaliana	154-158
12805609-4	2003	Split-root experiments show that the expression of IRT1 and FRO2 is controlled both by a local induction from the root iron pool and through a systemic pathway involving a shoot-borne signal, both signals being integrated to tightly control production of the root iron uptake proteins.	Iron	119-123	ferric reduction oxidase 2	Arabidopsis thaliana	60-64
12805609-4	2003	Split-root experiments show that the expression of IRT1 and FRO2 is controlled both by a local induction from the root iron pool and through a systemic pathway involving a shoot-borne signal, both signals being integrated to tightly control production of the root iron uptake proteins.	Iron	264-268	ferric reduction oxidase 2	Arabidopsis thaliana	60-64
12805609-7	2003	On the basis of the new molecular insights provided in this study and given the strict coregulation of IRT1 and FRO2 observed, we present a model of local and long-distance regulation of the root iron uptake system in Arabidopsis.	Iron	196-200	ferric reduction oxidase 2	Arabidopsis thaliana	112-116
12901180-3	2003	IN CONCLUSION: Our data proves the preliminary results, so idebenobe treatment is very effective in the disease, where a deficiency of frataxin is involved in the regulation of mitochondral iron content which is responsible for myocardial injury.	Iron	190-194	frataxin	Homo sapiens	135-143
12729948-0	2003	Alterations in cellular IRP-dependent iron regulation by in vitro manganese exposure in undifferentiated PC12 cells.	Iron	38-42	caspase 3	Rattus norvegicus	24-27
12729948-3	2003	In vitro manganese exposure altered the cellular abundance of TfR, H-/L-ferritin, and m-aconitase, resulting in an increase in labile iron.	Iron	134-138	transferrin receptor	Rattus norvegicus	62-65
17383861-5	2007	Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart.	Iron	36-40	ceruloplasmin	Rattus norvegicus	83-96
12769782-10	2003	Another recently described apicoplast enzyme, ferredoxin-NADP(+)-reductase and its redox partner, ferredoxin, points to another interesting organelle-specific biosynthetic pathway, namely [Fe-S] cluster biosynthesis.	Iron	189-193	ferredoxin reductase	Homo sapiens	46-74
17383861-5	2007	Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart.	Iron	36-40	ceruloplasmin	Rattus norvegicus	98-100
17383861-6	2007	We demonstrated that iron has a significant effect on expression of Fpn1 and CP, but not Heph.	Iron	21-25	ceruloplasmin	Rattus norvegicus	77-79
12712355-1	2003	Serum soluble transferrin receptor (sTfR) has been proposed as a more stable index of iron status than serum ferritin in athletes.	Iron	86-90	transferrin receptor	Homo sapiens	14-34
12755598-0	2003	Structure of frataxin iron cores: an X-ray absorption spectroscopic study.	Iron	22-26	frataxin	Homo sapiens	13-21
17383861-7	2007	Treatment of a high-iron diet induced a significant increase in Fpn1, a decrease in CP but no change in Heph mRNA and protein.	Iron	20-24	ceruloplasmin	Rattus norvegicus	84-86
12755598-1	2003	X-ray absorption spectroscopy at the iron K-edge indicates that the iron cores of human and yeast frataxin polymers assembled in vitro are identical to each other and are similar but not identical to ferritin cores.	Iron	37-41	frataxin	Homo sapiens	98-106
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	49-53	ceruloplasmin	Rattus norvegicus	24-26
12755598-1	2003	X-ray absorption spectroscopy at the iron K-edge indicates that the iron cores of human and yeast frataxin polymers assembled in vitro are identical to each other and are similar but not identical to ferritin cores.	Iron	68-72	frataxin	Homo sapiens	98-106
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	49-53	ceruloplasmin	Rattus norvegicus	153-155
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	159-163	ceruloplasmin	Rattus norvegicus	24-26
17383861-8	2007	The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron.	Iron	159-163	ceruloplasmin	Rattus norvegicus	153-155
12739969-0	2003	Silylene-bridged dinuclear iron complexes [Cp(OC)2Fe]2SiX2 (X = H, F, Cl, Br, I).	Iron	27-31	SIX homeobox 2	Homo sapiens	54-58
14605594-5	2003	The latter, interacting with beta-2microglobulin-HFE-TfR1 complex determines an iron retention within the macrophages of the entherocyte in the duodenal pit.	Iron	80-84	transferrin receptor	Homo sapiens	53-57
16927405-5	2007	We found that iron uptake in this cell type is mediated by divalent-metal transporter 1 (DMT1) and transferrin receptor-1 (TfR) whereas Ferroportin-1 is very weakly expressed.	Iron	14-18	transferrin receptor	Homo sapiens	99-121
14570998-4	2003	Frataxin is now thought to interfere with the mitochondrial oxidative process and enhance iron accumulation.	Iron	90-94	frataxin	Homo sapiens	0-8
12739969-2	2003	The mu2-silylene-bridged iron complexes [Cp(OC)(2)Fe](2)SiX(2) (X = F (2), Br (4), I (5)) have been prepared from the mu2-SiH(2) functional precursor [Cp(OC)(2)Fe](2)SiH(2) (1) by hydrogen/halogen exchange, using HBF(4), CBr(4), and CH(2)I(2), respectively.	Iron	25-29	adaptor related protein complex 1 subunit mu 2	Homo sapiens	4-7
12739969-2	2003	The mu2-silylene-bridged iron complexes [Cp(OC)(2)Fe](2)SiX(2) (X = F (2), Br (4), I (5)) have been prepared from the mu2-SiH(2) functional precursor [Cp(OC)(2)Fe](2)SiH(2) (1) by hydrogen/halogen exchange, using HBF(4), CBr(4), and CH(2)I(2), respectively.	Iron	25-29	adaptor related protein complex 1 subunit mu 2	Homo sapiens	118-121
12739969-2	2003	The mu2-silylene-bridged iron complexes [Cp(OC)(2)Fe](2)SiX(2) (X = F (2), Br (4), I (5)) have been prepared from the mu2-SiH(2) functional precursor [Cp(OC)(2)Fe](2)SiH(2) (1) by hydrogen/halogen exchange, using HBF(4), CBr(4), and CH(2)I(2), respectively.	Iron	50-52	adaptor related protein complex 1 subunit mu 2	Homo sapiens	4-7
12739969-7	2003	A significant dependence of the CO and Fe-Si stretching modes on the X substituents of the mu2-silylene bridge has been observed and discussed.	Iron	39-41	adaptor related protein complex 1 subunit mu 2	Homo sapiens	91-94
12729948-6	2003	These data indicate that at lower exposures, manganese directly interfered with IRP-dependent translational events, producing an increase in labile iron, which in turn signaled a decrease in IRP binding at 24 h. At higher exposures, the intracellular burden of manganese resulted in overt cytotoxicity and appeared to compromise the normal compensatory response to increased labile iron, producing increased IRP binding.	Iron	148-152	caspase 3	Rattus norvegicus	80-83
16927405-5	2007	We found that iron uptake in this cell type is mediated by divalent-metal transporter 1 (DMT1) and transferrin receptor-1 (TfR) whereas Ferroportin-1 is very weakly expressed.	Iron	14-18	transferrin receptor	Homo sapiens	123-126
12522003-3	2003	We investigated transferrin receptor (TfR)-dependent and -independent iron transport mechanisms in cytokine-stimulated human monocytic cell lines THP-1 and U937.	Iron	70-74	transferrin receptor	Homo sapiens	16-36
12522003-3	2003	We investigated transferrin receptor (TfR)-dependent and -independent iron transport mechanisms in cytokine-stimulated human monocytic cell lines THP-1 and U937.	Iron	70-74	transferrin receptor	Homo sapiens	38-41
16927405-7	2007	The expression of DMT1 and HFE barely varies upon endotoxin-induced maturation but TfR is up-regulated and the iron export molecule Ferroportin-1 is down-regulated.	Iron	111-115	homeostatic iron regulator	Homo sapiens	27-30
12522003-9	2003	Opposite, the anti-inflammatory cytokine IL-10 stimulates TfR-mediated iron uptake into activated monocytes.	Iron	71-75	transferrin receptor	Homo sapiens	58-61
12746546-2	2003	IRP1 is an iron-sulfur cluster-containing protein that can be converted from a cytosolic aconitase to an RNA binding posttranscriptional regulator in response to nitric oxide (NO).	Iron	11-15	aconitase 1	Homo sapiens	0-4
16927405-9	2007	Our results indicate that the uptake of iron during DCs development and maturation is mediated by a strong expression of iron-uptake molecules such as DMT1 and TfR as well as a down-regulation of iron export molecules such as Ferroportin-1.	Iron	40-44	transferrin receptor	Homo sapiens	160-163
17285345-0	2007	N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins.	Iron	11-15	frataxin	Homo sapiens	48-56
12393473-7	2003	Remarkably, the gene responses elicited by the altered expression of the hemochromatosis protein HFE and by pharmacological iron chelation exhibit the highest degree of relatedness, both for iron-regulatory protein (IRP) and non-IRP target genes.	Iron	124-128	homeostatic iron regulator	Homo sapiens	97-100
12393473-7	2003	Remarkably, the gene responses elicited by the altered expression of the hemochromatosis protein HFE and by pharmacological iron chelation exhibit the highest degree of relatedness, both for iron-regulatory protein (IRP) and non-IRP target genes.	Iron	124-128	Wnt family member 2	Homo sapiens	191-214
12393473-7	2003	Remarkably, the gene responses elicited by the altered expression of the hemochromatosis protein HFE and by pharmacological iron chelation exhibit the highest degree of relatedness, both for iron-regulatory protein (IRP) and non-IRP target genes.	Iron	124-128	Wnt family member 2	Homo sapiens	216-219
12393473-7	2003	Remarkably, the gene responses elicited by the altered expression of the hemochromatosis protein HFE and by pharmacological iron chelation exhibit the highest degree of relatedness, both for iron-regulatory protein (IRP) and non-IRP target genes.	Iron	124-128	Wnt family member 2	Homo sapiens	229-232
12393473-8	2003	This finding suggests that HFE expression directly affects the intracellular chelatable iron pool in the transgenic cell line.	Iron	88-92	homeostatic iron regulator	Homo sapiens	27-30
12704209-2	2003	The cognate proteins, HFE and TfR2, are therefore of key importance in human iron homeostasis.	Iron	77-81	homeostatic iron regulator	Homo sapiens	22-25
12704209-3	2003	HFE is expressed in small intestinal crypt cells where transferrin-iron entry may determine subsequent iron absorption by mature enterocytes, but the physiological function of TfR2 is unknown.	Iron	67-71	homeostatic iron regulator	Homo sapiens	0-3
12733906-1	2003	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin-dependent, nonheme iron enzyme that catalyzes the hydroxylation of L-Phe to L-Tyr in the rate-limiting step of phenylalanine catabolism.	Iron	76-80	phenylalanine hydroxylase	Homo sapiens	0-25
12733906-1	2003	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin-dependent, nonheme iron enzyme that catalyzes the hydroxylation of L-Phe to L-Tyr in the rate-limiting step of phenylalanine catabolism.	Iron	76-80	phenylalanine hydroxylase	Homo sapiens	27-30
12878293-3	2003	Frataxin is a mitochondrial protein that plays a role in iron homeostasis.	Iron	57-61	frataxin	Homo sapiens	0-8
12878293-4	2003	Deficiency of frataxin results in mitochondrial iron accumulation, defects in specific mitochondrial enzymes, enhanced sensitivity to oxidative stress, and eventually free-radical mediated cell death.	Iron	48-52	frataxin	Homo sapiens	14-22
12704209-3	2003	HFE is expressed in small intestinal crypt cells where transferrin-iron entry may determine subsequent iron absorption by mature enterocytes, but the physiological function of TfR2 is unknown.	Iron	103-107	homeostatic iron regulator	Homo sapiens	0-3
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	148-152	homeostatic iron regulator	Homo sapiens	23-26
12679054-11	2003	DFX reduced myoglobin induced effects on LDH leakage but had no effect on gluconeogenesis suggesting that myoglobin toxicity had an iron dependent (LDH) and independent (gluconeogenesis) pathway.	Iron	132-136	myoglobin	Rattus norvegicus	106-115
17285345-0	2007	N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins.	Iron	72-76	frataxin	Homo sapiens	48-56
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	148-152	homeostatic iron regulator	Homo sapiens	199-202
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	305-309	homeostatic iron regulator	Homo sapiens	23-26
17285345-1	2007	Frataxin is an iron-binding mitochondrial matrix protein that has been shown to mediate iron delivery during iron-sulfur cluster and heme biosynthesis.	Iron	15-19	frataxin	Homo sapiens	0-8
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	305-309	homeostatic iron regulator	Homo sapiens	199-202
12668611-0	2003	Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1).	Iron	0-4	frataxin	Homo sapiens	59-67
17285345-1	2007	Frataxin is an iron-binding mitochondrial matrix protein that has been shown to mediate iron delivery during iron-sulfur cluster and heme biosynthesis.	Iron	88-92	frataxin	Homo sapiens	0-8
17285345-1	2007	Frataxin is an iron-binding mitochondrial matrix protein that has been shown to mediate iron delivery during iron-sulfur cluster and heme biosynthesis.	Iron	88-92	frataxin	Homo sapiens	0-8
17285345-4	2007	Herein we show that the N-terminus of MPP-processed frataxin shows a unique high-affinity iron site and that this iron center appears to mediate a self-cleavage reaction.	Iron	90-94	frataxin	Homo sapiens	52-60
12732471-6	2003	We showed that SpvB is secreted into supernatant from Salmonella strains that contain the cloned spvB gene on a plasmid when they grew in intracellular salts medium (ISM), a minimal medium mimicing the intracellular iron concentrations of eukaryotic cells.	Iron	216-220	virulence protein	Salmonella enterica	15-19
12523938-0	2003	1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide.	Iron	130-134	transferrin receptor	Homo sapiens	99-119
17285345-4	2007	Herein we show that the N-terminus of MPP-processed frataxin shows a unique high-affinity iron site and that this iron center appears to mediate a self-cleavage reaction.	Iron	114-118	frataxin	Homo sapiens	52-60
12523938-10	2003	MPP(+)-treatment enhanced the cell-surface transferrin receptor (TfR) expression, suggesting a role for TfR-induced iron uptake in MPP(+) toxicity.	Iron	116-120	transferrin receptor	Homo sapiens	43-63
17443181-7	2007	Here we report cooling rates for group IVA iron meteorites that range from 100 to 6,000 K Myr(-1), increasing with decreasing bulk Ni.	Iron	43-47	myosin IB	Homo sapiens	90-96
12523938-10	2003	MPP(+)-treatment enhanced the cell-surface transferrin receptor (TfR) expression, suggesting a role for TfR-induced iron uptake in MPP(+) toxicity.	Iron	116-120	transferrin receptor	Homo sapiens	65-68
12523938-10	2003	MPP(+)-treatment enhanced the cell-surface transferrin receptor (TfR) expression, suggesting a role for TfR-induced iron uptake in MPP(+) toxicity.	Iron	116-120	transferrin receptor	Homo sapiens	104-107
12672910-11	2003	These changes, together with the reduction of nonheme iron concentrations in both FO-0- and FO-1-fed rats, may explain the increase in activity and expression of IRP1.	Iron	54-58	aconitase 1	Rattus norvegicus	162-166
12672939-9	2003	Iron repletion at PND 21-49 normalized D(1)R, D(2)R, and DAT levels in the nucleus accumbens, PFC and ventral midbrain but not in the striatum.	Iron	0-4	solute carrier family 6 member 3	Rattus norvegicus	57-60
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	128-132	aconitase 1	Rattus norvegicus	154-159
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	128-132	aconitase 1	Rattus norvegicus	154-159
12705835-0	2003	S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein.	Iron	48-52	Lutheran suppressor, X-linked	Homo sapiens	25-29
17220296-2	2007	Fet3p turnover of Fe(II) supports high affinity iron uptake across the yeast plasma membrane, whereas its turnover of Cu(I) contributes to copper resistance in yeast.	Iron	48-52	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
12706453-7	2003	After iron treatment, caspase 3 activity increased significantly, as measured in a fluoregenic assay.	Iron	6-10	caspase 3	Rattus norvegicus	22-31
12706453-9	2003	Western blot revealed that iron treatment up-regulated the apoptosis-related gene p53 as well as its effector gene p21(waf1/cip1).	Iron	27-31	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	115-128
12480712-3	2003	Sequence analyses of the putative 5" regulatory region revealed that the SFT cDNA sequence corresponds to intron 6/exon 7 of UbcH5A, a member of E2 ubiquitin-conjugating enzymes, which is involved in the iron-dependent ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) E3 ligase complex.	Iron	204-208	ubiquitin conjugating enzyme E2 D1	Homo sapiens	125-131
12480712-3	2003	Sequence analyses of the putative 5" regulatory region revealed that the SFT cDNA sequence corresponds to intron 6/exon 7 of UbcH5A, a member of E2 ubiquitin-conjugating enzymes, which is involved in the iron-dependent ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) E3 ligase complex.	Iron	204-208	von Hippel-Lindau tumor suppressor	Homo sapiens	315-319
12714262-1	2003	Mutations in the class I-like Major Histocompatibility Complex gene HFE are associated with hereditary hemochromatosis (HH), a disorder caused by excessive iron uptake.	Iron	156-160	homeostatic iron regulator	Homo sapiens	68-71
16210821-5	2003	The iron-overloaded liver provided a natural source of paramagnetic contrast for detection of HCC.	Iron	4-8	HCC	Homo sapiens	94-97
12480712-4	2003	Further mRNA expression studies using a sequence-specific reverse transcriptase-polymerase chain reaction (RT-PCR) assay showed that UbcH5A is significantly up-regulated in the liver of iron-overloaded patients with hereditary hemochromatosis, as previously published for SFT.	Iron	186-190	ubiquitin conjugating enzyme E2 D1	Homo sapiens	133-139
17244611-6	2007	In the presence of hydrogen peroxide, however, IscA completely loses its iron binding activity, whereas CyaY becomes a competent iron-binding protein and attenuates the iron-mediated production of hydroxyl free radicals.	Iron	129-133	frataxin	Homo sapiens	104-108
12753664-5	2003	HFE has a tissue distribution compatible with a role in iron absorption (intestine), recycling (macrophages) and transport to the fetus (placenta).	Iron	56-60	homeostatic iron regulator	Homo sapiens	0-3
17244611-6	2007	In the presence of hydrogen peroxide, however, IscA completely loses its iron binding activity, whereas CyaY becomes a competent iron-binding protein and attenuates the iron-mediated production of hydroxyl free radicals.	Iron	129-133	frataxin	Homo sapiens	104-108
17327330-0	2007	Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance.	Iron	54-58	nicotinamide phosphoribosyltransferase	Homo sapiens	12-20
12464008-0	2003	The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.	Iron	53-57	homeostatic iron regulator	Homo sapiens	29-32
12464008-1	2003	HFE, an atypical MHC class I type molecule, has a critical, yet still elusive function in the regulation of systemic iron metabolism.	Iron	117-121	homeostatic iron regulator	Homo sapiens	0-3
12464008-2	2003	HFE mutations are linked to hereditary haemochromatosis type 1, a common autosomal recessive disorder of iron overload.	Iron	105-109	homeostatic iron regulator	Homo sapiens	0-3
12464008-6	2003	Consistent with earlier observations in other cell lines, the expression of wild-type or H63D, but not C282Y, HFE induces an apparent iron-deficient phenotype, manifested in the activation of iron-regulatory protein and concomitant increase in transferrin receptor levels and decrease in ferritin content.	Iron	134-138	homeostatic iron regulator	Homo sapiens	110-113
12464008-11	2003	These results suggest that the apparent iron-deficient phenotype elicited by HFE is not linked to beta(2)M insufficiency.	Iron	40-44	homeostatic iron regulator	Homo sapiens	77-80
12712648-4	2003	This mutation in the HFE protein in the intestinal crypt cells is supposed to lead to up-regulation of iron transporters for dietary iron in the mucosal cells at the tip of the duodenal villi.	Iron	103-107	homeostatic iron regulator	Homo sapiens	21-24
12712648-5	2003	As a consequence, an excess of absorbed iron accumulates in the major organs of the HFE-mutated patients, leading to multi-organ dysfunction.	Iron	40-44	homeostatic iron regulator	Homo sapiens	84-87
12712648-9	2003	Homozygosity for the Cys282Tyr-mutation plus biochemical and clinical evidence of iron overload renders the diagnosis of HFE-related primary haemochromatosis indisputable.	Iron	82-86	homeostatic iron regulator	Homo sapiens	121-124
17327330-7	2007	Obesity status and glucose tolerance status influenced the relationships among visfatin, insulin sensitivity, and parameters of iron metabolism.	Iron	128-132	nicotinamide phosphoribosyltransferase	Homo sapiens	79-87
12641614-5	2003	The urine concentration of albumin and beta 2-microglobulin, as well as the activity of N-acetyl-beta-D-glucosaminidase (NAG), correlated positively with serum ferritin concentration and liver iron deposition, as detected by MRI T2 values.	Iron	193-197	O-GlcNAcase	Homo sapiens	88-119
12641614-5	2003	The urine concentration of albumin and beta 2-microglobulin, as well as the activity of N-acetyl-beta-D-glucosaminidase (NAG), correlated positively with serum ferritin concentration and liver iron deposition, as detected by MRI T2 values.	Iron	193-197	O-GlcNAcase	Homo sapiens	121-124
12605386-1	2003	Blood transferrin receptor (TR) level is largely determined by the quantum of erythropoiesis and by intracellular iron content of the cells of the erythroid lineage.	Iron	114-118	transferrin receptor	Homo sapiens	6-26
17327330-12	2007	CONCLUSIONS: Serum visfatin concentration is significantly associated with parameters of iron metabolism, especially in subjects with altered glucose tolerance.	Iron	89-93	nicotinamide phosphoribosyltransferase	Homo sapiens	19-27
12605386-1	2003	Blood transferrin receptor (TR) level is largely determined by the quantum of erythropoiesis and by intracellular iron content of the cells of the erythroid lineage.	Iron	114-118	transferrin receptor	Homo sapiens	28-30
12605386-10	2003	In light of these observations it would be prudent to treat ACD patients with high serum TR levels with iron replacement therapy.	Iron	104-108	transferrin receptor	Homo sapiens	89-91
12644496-1	2003	The diphtheria toxin repressor (DtxR) is a transition metal ion-activated repressor that acts as a global regulatory element in the control of iron-sensitive genes in Corynebacterium diphtheriae.	Iron	143-147	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
12644496-1	2003	The diphtheria toxin repressor (DtxR) is a transition metal ion-activated repressor that acts as a global regulatory element in the control of iron-sensitive genes in Corynebacterium diphtheriae.	Iron	143-147	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
17378446-3	2007	Transferrin allele, which may influence the ability of pathogenic bacteria to acquire iron, was examined specifically as a host-level risk factor.	Iron	86-90	inhibitor of carbonic anhydrase	Equus caballus	0-11
12642662-3	2003	Comparison of the structure and function of transferrins with a completely unrelated protein hemopexin, which carries out the same function for heme, identifies molecular features that contribute to a successful protein system for iron acquisition, transport, and release.	Iron	231-235	hemopexin	Homo sapiens	93-102
12406888-1	2003	Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR).	Iron	9-13	transferrin receptor	Homo sapiens	102-122
12406888-1	2003	Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR).	Iron	9-13	transferrin receptor	Homo sapiens	124-127
12406888-2	2003	Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.	Iron	129-133	transferrin receptor	Homo sapiens	19-39
12614226-3	2003	HFE mutations increase iron absorption in patients with haemochromatosis, and the mean transferrin saturations and ferritin levels are mildly increased in heterozygotes, suggesting that HFE mutations may protect against iron depletion and iron deficiency anaemia.	Iron	220-224	homeostatic iron regulator	Homo sapiens	186-189
17378446-6	2007	RESULTS: Analyses demonstrated significant variation in clinical disease between ponies that possessed different alleles of iron binding transferrin protein but no significant effect from vaccination.	Iron	124-128	inhibitor of carbonic anhydrase	Equus caballus	137-148
17164404-6	2007	These findings were consistent with iron-induced intracellular LPO, which also resulted in a concentration-dependent decrease in hepatocyte Erk-1/2 phosphorylation and activity.	Iron	36-40	mitogen activated protein kinase 3	Rattus norvegicus	140-147
12555201-1	2003	Ceruloplasmin is a key enzyme involved in detoxifying ferrous iron, which can generate free radicals.	Iron	54-66	ceruloplasmin	Rattus norvegicus	0-13
17164404-7	2007	4-HNE and iron-induced inhibition of Erk-1/2 was inversely correlated with the accumulation of 4-HNE-Erk-1/2 monomer adducts.	Iron	10-14	mitogen activated protein kinase 3	Rattus norvegicus	37-44
17164404-7	2007	4-HNE and iron-induced inhibition of Erk-1/2 was inversely correlated with the accumulation of 4-HNE-Erk-1/2 monomer adducts.	Iron	10-14	mitogen activated protein kinase 1	Rattus norvegicus	101-108
12584213-0	2003	A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption.	Iron	122-126	cytochrome b reductase 1	Rattus norvegicus	47-52
17290224-1	2007	The C/EBPalpha transcription factor regulates hepatic nitrogen, glucose, lipid and iron metabolism.	Iron	83-87	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	4-14
12531241-1	2003	Transferrin receptor 1 (TfR1) which mediates uptake of transferrin-bound iron, is essential for life in mammals.	Iron	73-77	transferrin receptor	Homo sapiens	24-28
17291111-0	2007	Iron-molybdenum charge-transfer hybrids containing organometallic and inorganic fragments bridged by aryldiazenido ligands in a mu-eta(6):eta(1) coordination mode: syntheses, characterization, X-ray structures, electrochemistry, and theoretical investigation.	Iron	0-4	endothelin receptor type A	Homo sapiens	58-61
12657433-6	2003	With multiple cell types involved in iron metabolism, the function of HFE is likely to be complex.	Iron	37-41	homeostatic iron regulator	Homo sapiens	70-73
17291111-0	2007	Iron-molybdenum charge-transfer hybrids containing organometallic and inorganic fragments bridged by aryldiazenido ligands in a mu-eta(6):eta(1) coordination mode: syntheses, characterization, X-ray structures, electrochemistry, and theoretical investigation.	Iron	0-4	endothelin receptor type A	Homo sapiens	131-134
17284743-0	2007	Production of stable-isotope-labeled bovine heme and its use to measure heme-iron absorption in children.	Iron	77-81	HEME	Bos taurus	44-48
12674739-2	2003	Type 1 is due to a point mutation in the HFE gene (C282Y) and leads via an increase in intestinal iron absorption to iron overload and organ damage.	Iron	98-102	homeostatic iron regulator	Homo sapiens	41-44
12674739-2	2003	Type 1 is due to a point mutation in the HFE gene (C282Y) and leads via an increase in intestinal iron absorption to iron overload and organ damage.	Iron	117-121	homeostatic iron regulator	Homo sapiens	41-44
17284743-0	2007	Production of stable-isotope-labeled bovine heme and its use to measure heme-iron absorption in children.	Iron	77-81	HEME	Bos taurus	72-76
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	47-51	HEME	Bos taurus	42-46
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	68-70	HEME	Bos taurus	42-46
12507560-3	2003	In normoxic cells, pVHL targeting of HIF-alpha subunits follows hydroxylation of critical HIF prolyl residues by a group of oxygen, 2-oxoglutarate- and iron-dependent enzymes.	Iron	152-156	von Hippel-Lindau tumor suppressor	Homo sapiens	19-23
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	117-121	HEME	Bos taurus	112-116
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	117-121	HEME	Bos taurus	112-116
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	117-121	HEME	Bos taurus	112-116
12529348-2	2003	Mutations in the hemochromatosis (HFE) gene are associated with increased total body iron stores in some individuals.	Iron	85-89	homeostatic iron regulator	Homo sapiens	34-37
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	117-121	HEME	Bos taurus	112-116
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	117-121	HEME	Bos taurus	112-116
12522121-7	2003	We conclude that hydroperoxide-induced DCFH oxidation and endothelial cell apoptosis required the uptake of extracellular iron by the TfR-dependent iron transport mechanism and that the peroxide-induced iron signaling, in general, has broader implications in oxidative vascular biology.	Iron	122-126	transferrin receptor	Homo sapiens	134-137
12522121-7	2003	We conclude that hydroperoxide-induced DCFH oxidation and endothelial cell apoptosis required the uptake of extracellular iron by the TfR-dependent iron transport mechanism and that the peroxide-induced iron signaling, in general, has broader implications in oxidative vascular biology.	Iron	148-152	transferrin receptor	Homo sapiens	134-137
17284743-2	2007	OBJECTIVE: Our objectives were to produce heme iron enriched in (58)Fe and to use it to study the absorption of heme iron and the effect of iron and zinc intakes on heme-iron absorption in children.	Iron	117-121	HEME	Bos taurus	112-116
12522121-7	2003	We conclude that hydroperoxide-induced DCFH oxidation and endothelial cell apoptosis required the uptake of extracellular iron by the TfR-dependent iron transport mechanism and that the peroxide-induced iron signaling, in general, has broader implications in oxidative vascular biology.	Iron	148-152	transferrin receptor	Homo sapiens	134-137
17284743-5	2007	We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake increased and that higher zinc intakes would decrease heme-iron absorption.	Iron	37-41	HEME	Bos taurus	32-36
17284743-5	2007	We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake increased and that higher zinc intakes would decrease heme-iron absorption.	Iron	76-80	HEME	Bos taurus	32-36
12667993-5	2003	Since only eight out of 45 iron-overloaded HbH patients carry a defect in the TFR2 or HFE gene in the heterozygote state and their iron loading status was comparable to the matched controls without such defects, it would appear that the accumulation of excess iron in HbH disease is more likely a result of increase dietary absorption secondary to ineffective erythropoiesis.	Iron	27-31	hemoglobin subunit alpha 1	Homo sapiens	43-46
12667993-5	2003	Since only eight out of 45 iron-overloaded HbH patients carry a defect in the TFR2 or HFE gene in the heterozygote state and their iron loading status was comparable to the matched controls without such defects, it would appear that the accumulation of excess iron in HbH disease is more likely a result of increase dietary absorption secondary to ineffective erythropoiesis.	Iron	27-31	homeostatic iron regulator	Homo sapiens	86-89
17284743-5	2007	We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake increased and that higher zinc intakes would decrease heme-iron absorption.	Iron	76-80	HEME	Bos taurus	71-75
17284743-5	2007	We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake increased and that higher zinc intakes would decrease heme-iron absorption.	Iron	76-80	HEME	Bos taurus	71-75
17284743-5	2007	We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake increased and that higher zinc intakes would decrease heme-iron absorption.	Iron	76-80	HEME	Bos taurus	32-36
17284743-5	2007	We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake increased and that higher zinc intakes would decrease heme-iron absorption.	Iron	76-80	HEME	Bos taurus	71-75
12459918-1	2003	Iron regulatory protein 1 (IRP1) is a metalloprotein which regulates several proteins involved in mammalian iron homeostasis at a post-transcriptional level, by binding to specific mRNA sequences termed iron responsive elements (IREs).	Iron	108-112	aconitase 1	Homo sapiens	0-25
17284743-5	2007	We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake increased and that higher zinc intakes would decrease heme-iron absorption.	Iron	76-80	HEME	Bos taurus	71-75
12459918-1	2003	Iron regulatory protein 1 (IRP1) is a metalloprotein which regulates several proteins involved in mammalian iron homeostasis at a post-transcriptional level, by binding to specific mRNA sequences termed iron responsive elements (IREs).	Iron	108-112	aconitase 1	Homo sapiens	27-31
12459918-1	2003	Iron regulatory protein 1 (IRP1) is a metalloprotein which regulates several proteins involved in mammalian iron homeostasis at a post-transcriptional level, by binding to specific mRNA sequences termed iron responsive elements (IREs).	Iron	203-207	aconitase 1	Homo sapiens	0-25
17284743-7	2007	Fractional iron absorption in children was significantly affected by the intake of heme iron (P = 0.0013) and of zinc (P = 0.0375), but, contrary to expectations, heme-iron absorption was higher at higher zinc intakes.	Iron	11-15	HEME	Bos taurus	83-87
12459918-1	2003	Iron regulatory protein 1 (IRP1) is a metalloprotein which regulates several proteins involved in mammalian iron homeostasis at a post-transcriptional level, by binding to specific mRNA sequences termed iron responsive elements (IREs).	Iron	203-207	aconitase 1	Homo sapiens	27-31
17172925-2	2007	BACKGROUND: Friedreich"s ataxia is characterized by a mutant frataxin gene, which causes mitochondrial iron overload and impaired energy production.	Iron	103-107	frataxin	Homo sapiens	61-69
14618419-2	2003	C282Y and H63D mutations in the hemochromatosis (HFE) gene are associated with increased serum iron levels and consequently with hereditary hemochromatosis.	Iron	95-99	homeostatic iron regulator	Homo sapiens	49-52
15841243-2	2003	Here we have sequenced and characterized a full-length cDNA encoding a putative iron-binding transferrin (AmTRF) in the honeybee.	Iron	80-84	transferrin 1	Apis mellifera	106-111
17194693-1	2007	HFE mutations have traditionally been associated with the iron overload disorder known as hemochromatosis.	Iron	58-62	homeostatic iron regulator	Homo sapiens	0-3
15841243-3	2003	AmTRF shows high level of sequence identity with transferrins in both vertebrates and insects (26-46%) suggesting that the primary function of the predicted 712 amino acid protein is binding and transporting of iron.	Iron	211-215	transferrin 1	Apis mellifera	0-5
17096368-5	2007	The active domain of Aft1 necessary for activation of the FET3 promoter by cisplatin is identical to the one required for activation by bathophenanthroline sulfonate, an inhibitor of cellular iron uptake.	Iron	192-196	ferroxidase FET3	Saccharomyces cerevisiae S288C	58-62
12790309-1	2003	OBJECTIVES: Homozygosity for the C282Y mutation of the HFE gene is the main cause of iron overload in hereditary haemochromatosis.	Iron	85-89	homeostatic iron regulator	Homo sapiens	55-58
12806184-6	2003	Preincubating GEC with CYP2B1 inhibitors (piperine and cimetidine) and H(2)O(2) scavenger (pyruvate) significantly reduced H(2)O(2 )generation, preserved CYP2B1 content, prevented the increase in catalytic iron and hydroxyl radical formation including PAN-induced cytotoxicity.	Iron	206-210	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	23-29
12806184-8	2003	Our data thus indicate an important role of CYP2B1 in PAN-induced cytotoxicity by serving as a site of reactive oxygen metabolite generation and a significant source of catalytic iron.	Iron	179-183	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	44-50
12393445-8	2002	We identified a nonsense mutation in the cdy allele and demonstrated that, whereas wild-type zebrafish DMT1 protein can transport iron, the truncated protein expressed in cdy mutants is not functional.	Iron	130-134	solute carrier family 11 member 2	Danio rerio	103-107
12499114-11	2003	DFX reduced myoglobin induced effects on LDH leakage but had no effect on gluconeogenesis suggesting that myoglobin toxicity had an iron dependent (LDH) and independent (gluconeogenesis) pathway.	Iron	132-136	myoglobin	Rattus norvegicus	106-115
12622622-8	2003	Decreases of serum iron markers following chloroquine therapy were limited to patients with PCT and HFE wild type.	Iron	19-23	homeostatic iron regulator	Homo sapiens	100-103
12572661-6	2003	Yet another interaction may come from the IRE/IRP (Iron Responsive Element/Iron Regulatory Protein) story where a paradigmatic role in iron homeostasis is well established, but interaction with copper is only now emerging.	Iron	51-55	Wnt family member 2	Homo sapiens	42-49
12572661-6	2003	Yet another interaction may come from the IRE/IRP (Iron Responsive Element/Iron Regulatory Protein) story where a paradigmatic role in iron homeostasis is well established, but interaction with copper is only now emerging.	Iron	135-139	Wnt family member 2	Homo sapiens	42-49
12848962-5	2003	Growing evidence suggests that T cells may in turn, regulate iron metabolism perhaps through interactions with the non-classical major histocompatibility complex gene HFE.	Iron	61-65	homeostatic iron regulator	Homo sapiens	167-170
12589962-0	2003	Soluble transferrin receptor for the evaluation of erythropoiesis and iron status.	Iron	70-74	transferrin receptor	Homo sapiens	8-28
12589962-1	2003	Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	151-171
12589962-1	2003	Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	173-176
12589962-1	2003	Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR).	Iron	74-78	transferrin receptor	Homo sapiens	151-171
12589962-1	2003	Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR).	Iron	74-78	transferrin receptor	Homo sapiens	173-176
12631267-8	2003	Two alternative conformations, rotated 180 degrees around an imaginary iron-catecholamine axis, were found for DA and l-DOPA in PAH and for DA in TH.	Iron	71-75	phenylalanine hydroxylase	Homo sapiens	128-131
12592010-1	2003	Regulated expression of proteins involved in mammalian iron metabolism is achieved in part through the interaction of the iron regulatory proteins IRP1 and IRP2 with highly conserved RNA stem-loop structures, known as iron-responsive elements (IREs), that are located within the 5" or 3" untranslated regions of regulated transcripts.	Iron	55-59	aconitase 1	Homo sapiens	147-151
12592010-1	2003	Regulated expression of proteins involved in mammalian iron metabolism is achieved in part through the interaction of the iron regulatory proteins IRP1 and IRP2 with highly conserved RNA stem-loop structures, known as iron-responsive elements (IREs), that are located within the 5" or 3" untranslated regions of regulated transcripts.	Iron	122-126	aconitase 1	Homo sapiens	147-151
12592010-1	2003	Regulated expression of proteins involved in mammalian iron metabolism is achieved in part through the interaction of the iron regulatory proteins IRP1 and IRP2 with highly conserved RNA stem-loop structures, known as iron-responsive elements (IREs), that are located within the 5" or 3" untranslated regions of regulated transcripts.	Iron	122-126	aconitase 1	Homo sapiens	147-151
12606179-10	2003	INTERPRETATION: Lack of HAMP upregulation in HFE-associated haemochromatosis despite significant hepatic iron loading indicates that HFE plays an important part in the regulation of hepcidin expression in response to iron overload.	Iron	217-221	homeostatic iron regulator	Homo sapiens	133-136
12667008-1	2003	The objective of this study was to investigate whether the measurement of serum soluble transferrin receptor could detect subclinical iron deficiency in adolescent girls, and to assess the possible specificity-compromising effects of growth, menarche, and intensive physical activity.	Iron	134-138	transferrin receptor	Homo sapiens	88-108
12557137-0	2003	Hepatitis C, iron status, and disease severity: relationship with HFE mutations.	Iron	13-17	homeostatic iron regulator	Homo sapiens	66-69
12557137-1	2003	BACKGROUND &amp; AIMS: Mild to moderate hepatic iron loading is common in patients with chronic hepatitis C. We sought to determine whether mutations in the hemochromatosis gene, HFE, are associated with iron overload and acceleration of disease progression in hepatitis C patients.	Iron	48-52	homeostatic iron regulator	Homo sapiens	179-182
12557137-1	2003	BACKGROUND &amp; AIMS: Mild to moderate hepatic iron loading is common in patients with chronic hepatitis C. We sought to determine whether mutations in the hemochromatosis gene, HFE, are associated with iron overload and acceleration of disease progression in hepatitis C patients.	Iron	204-208	homeostatic iron regulator	Homo sapiens	179-182
12557137-4	2003	RESULTS: Among patients with compensated liver disease, the presence of HFE mutations was independently associated with elevations in serum iron level, serum transferrin-iron saturation, serum ferritin level, and hepatic iron index (P &lt; 0.05).	Iron	140-144	homeostatic iron regulator	Homo sapiens	72-75
12557137-4	2003	RESULTS: Among patients with compensated liver disease, the presence of HFE mutations was independently associated with elevations in serum iron level, serum transferrin-iron saturation, serum ferritin level, and hepatic iron index (P &lt; 0.05).	Iron	170-174	homeostatic iron regulator	Homo sapiens	72-75
12557137-4	2003	RESULTS: Among patients with compensated liver disease, the presence of HFE mutations was independently associated with elevations in serum iron level, serum transferrin-iron saturation, serum ferritin level, and hepatic iron index (P &lt; 0.05).	Iron	170-174	homeostatic iron regulator	Homo sapiens	72-75
12557137-8	2003	CONCLUSIONS: The presence of HFE mutations is independently associated with iron loading and advanced fibrosis in patients with compensated liver disease from chronic hepatitis C, especially after controlling for duration of disease.	Iron	76-80	homeostatic iron regulator	Homo sapiens	29-32
12674437-1	2003	The relationship between high dietary iron intake, mutations of the HFE gene, and iron status, and their effects on human health are reviewed.	Iron	38-42	homeostatic iron regulator	Homo sapiens	68-71
12674437-1	2003	The relationship between high dietary iron intake, mutations of the HFE gene, and iron status, and their effects on human health are reviewed.	Iron	82-86	homeostatic iron regulator	Homo sapiens	68-71
12674437-3	2003	Homozygotes for the C282Y mutation of the HFE gene have elevated body iron levels.	Iron	70-74	homeostatic iron regulator	Homo sapiens	42-45
12674437-6	2003	The dietary levels of iron associated with health risks in different HFE genotypes must be determined.	Iron	22-26	homeostatic iron regulator	Homo sapiens	69-72
12438312-1	2003	Iron regulatory protein-1 (IRP-1) is a cytosolic RNA-binding protein that is a regulator of iron homeostasis in mammalian cells.	Iron	92-96	aconitase 1	Homo sapiens	0-25
12438312-1	2003	Iron regulatory protein-1 (IRP-1) is a cytosolic RNA-binding protein that is a regulator of iron homeostasis in mammalian cells.	Iron	92-96	aconitase 1	Homo sapiens	27-32
12438312-2	2003	IRP-1 binds to RNA structures, known as iron-responsive elements, located in the untranslated regions of specific mRNAs, and it regulates the translation or stability of these mRNAs.	Iron	40-44	aconitase 1	Homo sapiens	0-5
12438312-3	2003	Iron regulates IRP-1 activity by converting it from an RNA-binding apoprotein into a [4Fe-4S] cluster protein exhibiting aconitase activity.	Iron	0-4	aconitase 1	Homo sapiens	15-20
12438312-7	2003	Like mammalian IRP-1/aconitases, GEI-22/ACO-1 exhibits aconitase activity and is post-translationally regulated by iron.	Iron	115-119	aconitase 1	Homo sapiens	15-20
12438312-7	2003	Like mammalian IRP-1/aconitases, GEI-22/ACO-1 exhibits aconitase activity and is post-translationally regulated by iron.	Iron	115-119	aconitase 1	Homo sapiens	40-45
12529348-14	2003	Among those with HFE mutations, cancer risk increased with increasing age and total iron intake.	Iron	84-88	homeostatic iron regulator	Homo sapiens	17-20
12624489-3	2003	The difference between the HFE-positive and HFE-negative MDS patients as regards initial serum iron and transferrin saturation was not significant.	Iron	95-99	homeostatic iron regulator	Homo sapiens	27-30
14671616-1	2003	The occurrence of the C282Y and H63D mutations of the HFE gene, responsible for toxic iron overload in the liver (hereditary hemochromatosis), was still unknown in Tunisia.	Iron	86-90	homeostatic iron regulator	Homo sapiens	54-57
14671617-1	2003	The aim of this study was to analyze the role of HFE mutations in blood donors with iron parameters suggesting iron overload, taking into account the regional distribution of HFE mutations in Italy.	Iron	84-88	homeostatic iron regulator	Homo sapiens	49-52
14671617-1	2003	The aim of this study was to analyze the role of HFE mutations in blood donors with iron parameters suggesting iron overload, taking into account the regional distribution of HFE mutations in Italy.	Iron	111-115	homeostatic iron regulator	Homo sapiens	49-52
17003003-12	2003	In conclusion, DM2 patients have increased iron load.	Iron	43-47	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	15-18
17003003-13	2003	The C282Y and H63D mutations contribute to increased iron load in both DM2 and controls.	Iron	53-57	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	71-74
12459918-5	2003	We showed that, in both settings, IRP1 lost aconitase activity and iron concomitantly.	Iron	67-71	aconitase 1	Homo sapiens	34-38
12459918-6	2003	Iron release reached 3.5-4 iron atoms per IRP1 molecule, proving that the Fe-S cluster was completely disrupted.	Iron	0-4	aconitase 1	Homo sapiens	42-46
12459918-6	2003	Iron release reached 3.5-4 iron atoms per IRP1 molecule, proving that the Fe-S cluster was completely disrupted.	Iron	74-76	aconitase 1	Homo sapiens	42-46
12938016-3	2003	Recently frataxin was shown to have an identical phylogenetic distribution with two genes and was most likely specifically involved in the same sub-process in iron-sulfur cluster assembly as one gene, designated hscB, in bacteria.	Iron	159-163	frataxin	Homo sapiens	9-17
12937836-9	2003	In addition, HeLa cells exposed to hyperoxia retained inducibility of CAIX expression by transition metals and iron chelators, suggesting that they act independently of cell density mediated-pO2-gradient or at a downstream site from oxygen sensor.	Iron	111-115	carbonic anhydrase 9	Homo sapiens	70-74
12509560-1	2003	OBJECTIVE: To evaluate a secondary liver iron overload and its fate in children who are treated conventionally for acute lymphoblastic leukemia and to assess whether serum soluble transferrin receptor (sTfR) is useful in detecting iron load.	Iron	231-235	transferrin receptor	Homo sapiens	180-200
12964953-5	2003	HO-1 and its constitutively expressed isozyme, heme oxygenase-2, catalyze the rate-limiting step in the conversion of heme to its metabolites, bilirubin IXalpha, ferrous iron, and carbon monoxide (CO).	Iron	170-174	heme oxygenase 2	Homo sapiens	47-63
12508966-4	2002	METHODS: C282Y/H63D mutations of HFE gene were evaluated in 132 patients (34 in peritoneal dialysis, 98 in HD) and correlated with biochemical parameters of iron status (ferritin (FER) concentration and transferrin saturation (TSAT)), red cell parameters (red cell size and hemoglobin content), erythropoietin (EPO) dosage, major cardiovascular events and C-reactive protein as marker of chronic inflammation, in patients without iron therapy and after i.v.	Iron	157-161	homeostatic iron regulator	Homo sapiens	33-36
12508966-4	2002	METHODS: C282Y/H63D mutations of HFE gene were evaluated in 132 patients (34 in peritoneal dialysis, 98 in HD) and correlated with biochemical parameters of iron status (ferritin (FER) concentration and transferrin saturation (TSAT)), red cell parameters (red cell size and hemoglobin content), erythropoietin (EPO) dosage, major cardiovascular events and C-reactive protein as marker of chronic inflammation, in patients without iron therapy and after i.v.	Iron	430-434	homeostatic iron regulator	Homo sapiens	33-36
12429122-0	2002	Structured RNA upstream of insect cap distal iron responsive elements enhances iron regulatory protein-mediated control of translation.	Iron	45-49	Wnt family member 2	Homo sapiens	79-102
12429122-1	2002	Iron regulatory protein (IRP) blocks ribosomal assembly by binding to an iron responsive element (IRE) located proximal (&lt;60 nts) to the mRNA cap, thereby repressing translation.	Iron	73-77	Wnt family member 2	Homo sapiens	0-23
12429122-1	2002	Iron regulatory protein (IRP) blocks ribosomal assembly by binding to an iron responsive element (IRE) located proximal (&lt;60 nts) to the mRNA cap, thereby repressing translation.	Iron	73-77	Wnt family member 2	Homo sapiens	25-28
12445428-0	2002	Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. BACKGROUND/AIMS: Recent evidence implicates iron as a comorbid factor for development of non-hemochromatotic liver diseases.	Iron	151-155	transferrin receptor	Homo sapiens	16-20
12445428-1	2002	Mutations or polymorphisms in the HFE gene or the TfR1 gene may influence the accumulation of iron in the liver or other tissues or may influence chronic viral hepatitis apart from effects on iron homeostasis.	Iron	94-98	homeostatic iron regulator	Homo sapiens	34-37
12445428-1	2002	Mutations or polymorphisms in the HFE gene or the TfR1 gene may influence the accumulation of iron in the liver or other tissues or may influence chronic viral hepatitis apart from effects on iron homeostasis.	Iron	94-98	transferrin receptor	Homo sapiens	50-54
12445428-1	2002	Mutations or polymorphisms in the HFE gene or the TfR1 gene may influence the accumulation of iron in the liver or other tissues or may influence chronic viral hepatitis apart from effects on iron homeostasis.	Iron	192-196	homeostatic iron regulator	Homo sapiens	34-37
12445428-1	2002	Mutations or polymorphisms in the HFE gene or the TfR1 gene may influence the accumulation of iron in the liver or other tissues or may influence chronic viral hepatitis apart from effects on iron homeostasis.	Iron	192-196	transferrin receptor	Homo sapiens	50-54
12444762-2	2002	From the compositional and structural analyses for the adduct of FeCl(3)/DMF using various techniques such as FTIR, elemental analysis, UV/vis, XPS, and TGA/DTG, it was found that the iron cation exists in the form of an Fe(3+) cation and coordinates via the carbonyl oxygen atom of amide bond in DMF.	Iron	184-188	T-box transcription factor 1	Homo sapiens	153-156
17240320-1	2007	Homozygosity for a novel hemochromatosis (HFE) gene splice site mutation (IVS5+1 G/A) was previously reported in a 48-year-old Vietnamese man residing in Germany who had an elevated serum ferritin (SF) and transferrin saturation (TS) and severe iron overload on liver biopsy.	Iron	245-249	homeostatic iron regulator	Homo sapiens	42-45
27265186-15	2002	Thus, TfR-F index proved useful in evaluating the changes of iron metabolism and reducing iron necessities in patients.	Iron	61-65	transferrin receptor	Homo sapiens	6-9
27265186-15	2002	Thus, TfR-F index proved useful in evaluating the changes of iron metabolism and reducing iron necessities in patients.	Iron	90-94	transferrin receptor	Homo sapiens	6-9
12685490-5	2002	The DNA was investigated for mutations in the HFE gene when one of these iron parameters was elevated.	Iron	73-77	homeostatic iron regulator	Homo sapiens	46-49
12457803-5	2002	Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter.	Iron	77-81	homeostatic iron regulator	Homo sapiens	37-40
12457803-5	2002	Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter.	Iron	220-224	homeostatic iron regulator	Homo sapiens	37-40
17207512-2	2007	The BET surface areas of these nano-scale particles were around two orders of magnitude higher than that of the commercial micro-scale Fe particles.	Iron	135-137	delta/notch like EGF repeat containing	Homo sapiens	4-7
12200453-0	2002	Multiple, conserved iron-responsive elements in the 3"-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2.	Iron	20-24	transferrin receptor	Homo sapiens	78-98
12200453-1	2002	Synthesis of proteins for iron homeostasis is regulated by specific, combinatorial mRNA/protein interactions between RNA stem-loop structures (iron-responsive elements, IREs) and iron-regulatory proteins (IRP1 and IRP2), controlling either mRNA translation or stability.	Iron	26-30	aconitase 1	Homo sapiens	205-209
12200453-6	2002	Changes in TfR-IRE structure conferred by the full length TfR-3"-UTR mRNA explain in part evolutionary conservation of multiple IRE-RNA, which allows TfR mRNA stabilization and receptor synthesis when IRP activity varies, and ensures iron uptake for cell growth.	Iron	234-238	transferrin receptor	Homo sapiens	11-14
12200453-6	2002	Changes in TfR-IRE structure conferred by the full length TfR-3"-UTR mRNA explain in part evolutionary conservation of multiple IRE-RNA, which allows TfR mRNA stabilization and receptor synthesis when IRP activity varies, and ensures iron uptake for cell growth.	Iron	234-238	transferrin receptor	Homo sapiens	58-61
12200453-6	2002	Changes in TfR-IRE structure conferred by the full length TfR-3"-UTR mRNA explain in part evolutionary conservation of multiple IRE-RNA, which allows TfR mRNA stabilization and receptor synthesis when IRP activity varies, and ensures iron uptake for cell growth.	Iron	234-238	transferrin receptor	Homo sapiens	58-61
12200453-6	2002	Changes in TfR-IRE structure conferred by the full length TfR-3"-UTR mRNA explain in part evolutionary conservation of multiple IRE-RNA, which allows TfR mRNA stabilization and receptor synthesis when IRP activity varies, and ensures iron uptake for cell growth.	Iron	234-238	Wnt family member 2	Homo sapiens	201-204
12388055-0	2002	Regulation of xanthine oxidoreductase by intracellular iron.	Iron	55-59	xanthine dehydrogenase	Homo sapiens	14-37
12388055-2	2002	Because tissue iron levels increase after ischemia, and because XOR contains functionally critical iron-sulfur clusters, we studied the effects of intracellular iron on XOR expression.	Iron	99-103	xanthine dehydrogenase	Homo sapiens	64-67
12388055-2	2002	Because tissue iron levels increase after ischemia, and because XOR contains functionally critical iron-sulfur clusters, we studied the effects of intracellular iron on XOR expression.	Iron	99-103	xanthine dehydrogenase	Homo sapiens	64-67
12388055-4	2002	Iron increased XOR protein and mRNA levels, whereas protein and RNA synthesis inhibitors abolished the induction of XOR activity.	Iron	0-4	xanthine dehydrogenase	Homo sapiens	15-18
12388055-7	2002	Iron chelation by deferoxamine (DFO) decreased XOR activity but did not lower endogenous XOR protein or mRNA levels.	Iron	0-4	xanthine dehydrogenase	Homo sapiens	47-50
17097691-8	2007	Collectively, these results suggest that PKCdelta plays a pivotal role in signaling pathways leading to iron chelator-induced IL-8 production in human IECs.	Iron	104-108	protein kinase C delta	Homo sapiens	41-49
12405528-3	2002	Carriers of HFE gene mutations should be advised to minimize contributing factors, if possible, and to have their iron values tested periodically.	Iron	114-118	homeostatic iron regulator	Homo sapiens	12-15
12406098-1	2002	Iron overload may predominantly involve parenchymal or reticuloendothelial cells, the prototype of parenchymal iron overload being HFE-related genetic haemochromatosis.	Iron	111-115	homeostatic iron regulator	Homo sapiens	131-134
16935854-8	2007	Likewise, expression of genes participating in duodenal Fe uptake (Dcytb, DMT1) and transfer (ferroportin) were increased in TfR2 mutant mice.	Iron	56-58	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	74-78
12547229-9	2002	The uptake of transferrin-bound iron and expression of functional TfR1 was shown to occur mainly in crypt cells and to be proportional to the plasma concentration of iron.	Iron	166-170	transferrin receptor	Rattus norvegicus	66-70
12547230-1	2002	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	transferrin receptor	Mus musculus	66-87
12547230-1	2002	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	transferrin receptor	Mus musculus	89-92
12547230-2	2002	Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin.	Iron	9-13	transferrin receptor	Mus musculus	83-86
12547230-4	2002	), a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels and a decrease in ferritin synthesis.	Iron	65-69	transferrin receptor	Mus musculus	138-141
12480800-4	2002	The serum transferrin receptor to serum ferritin ratio was significantly greater for the iron depleted group prior to supplementation (890 +/- 753) versus the control group (151 +/- 61).	Iron	89-93	transferrin receptor	Homo sapiens	10-30
12468620-1	2002	Iron deficiency is the most common micronutrient deficiency worldwide, and transferrin receptor (TfR) level has been identified as an important measure of iron status that is not confounded by inflammation.	Iron	155-159	transferrin receptor	Homo sapiens	75-95
17297430-0	2007	Association of HFE mutations (C282Y and H63D) with iron overload in blood donors from Mexico City.	Iron	51-55	homeostatic iron regulator	Homo sapiens	15-18
12468620-1	2002	Iron deficiency is the most common micronutrient deficiency worldwide, and transferrin receptor (TfR) level has been identified as an important measure of iron status that is not confounded by inflammation.	Iron	155-159	transferrin receptor	Homo sapiens	97-100
12429868-1	2002	The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.	Iron	110-114	transferrin receptor	Rattus norvegicus	13-33
12429868-1	2002	The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.	Iron	175-179	transferrin receptor	Rattus norvegicus	13-33
12429850-0	2002	The hemochromatosis protein HFE inhibits iron export from macrophages.	Iron	41-45	homeostatic iron regulator	Homo sapiens	28-31
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	119-123	homeostatic iron regulator	Homo sapiens	4-7
12547235-1	2002	In the HFE-gene era, precise diagnostic parameters remain important to characterize individual iron stores, because the indication for therapy and prognosis are mainly related to the extent of iron loading.	Iron	95-99	homeostatic iron regulator	Homo sapiens	7-10
12547235-1	2002	In the HFE-gene era, precise diagnostic parameters remain important to characterize individual iron stores, because the indication for therapy and prognosis are mainly related to the extent of iron loading.	Iron	193-197	homeostatic iron regulator	Homo sapiens	7-10
12547237-1	2002	A rare recessive disorder which leads to iron overload and severe clinical complications similar to those reported in HFE-related hemochromatosis has been delineated and sometimes called hemochromatosis type 3.	Iron	41-45	homeostatic iron regulator	Homo sapiens	118-121
12183449-0	2002	C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism.	Iron	98-102	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	0-10
12183449-12	2002	Finally, iron overload led to a significant increase of C/EBPalpha protein and HEPC transcripts in mouse liver.	Iron	9-13	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	56-66
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	119-123	transferrin receptor	Homo sapiens	25-47
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	119-123	transferrin receptor	Homo sapiens	49-53
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	136-140	homeostatic iron regulator	Homo sapiens	4-7
12183449-13	2002	Taken together, these data demonstrate that C/EBPalpha is likely to be a key regulator of HEPC gene transcription and provide a novel mechanism for cross-talk between the C/EBP pathway and iron metabolism.	Iron	189-193	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	44-54
12183449-13	2002	Taken together, these data demonstrate that C/EBPalpha is likely to be a key regulator of HEPC gene transcription and provide a novel mechanism for cross-talk between the C/EBP pathway and iron metabolism.	Iron	189-193	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	44-49
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	136-140	transferrin receptor	Homo sapiens	25-47
17297430-1	2007	BACKGROUND AND OBJECTIVE: Iron overload has been associated with HFE mutations (C282Y and H63D).	Iron	26-30	homeostatic iron regulator	Homo sapiens	65-68
12429850-2	2002	The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake.	Iron	136-140	transferrin receptor	Homo sapiens	49-53
12429850-3	2002	However, in vivo, HFE is strongly expressed by liver macrophages and intestinal crypt cells, which behave as though they are relatively iron-deficient in HH.	Iron	136-140	homeostatic iron regulator	Homo sapiens	18-21
17098208-0	2007	Frataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions, redox alterations and induction of heme transcripts.	Iron	46-50	frataxin	Homo sapiens	0-8
12429850-4	2002	These latter observations suggest, paradoxically, that expression of wild-type HFE may lead to iron accumulation in these specialized cell types.	Iron	95-99	homeostatic iron regulator	Homo sapiens	79-82
12429850-5	2002	Here we show that wild-type HFE protein raises cellular iron by inhibiting iron efflux from the monocytemacrophage cell line THP-1, and extend these results to macrophages derived from healthy individuals and HH patients.	Iron	56-60	homeostatic iron regulator	Homo sapiens	28-31
12429850-5	2002	Here we show that wild-type HFE protein raises cellular iron by inhibiting iron efflux from the monocytemacrophage cell line THP-1, and extend these results to macrophages derived from healthy individuals and HH patients.	Iron	75-79	homeostatic iron regulator	Homo sapiens	28-31
12429850-7	2002	Finally, we show that the ability of HFE to block iron release is not competitively inhibited by transferrin.	Iron	50-54	homeostatic iron regulator	Homo sapiens	37-40
12429850-8	2002	We conclude that HFE has two mutually exclusive functions, binding to TfR1 in competition with Tf, or inhibition of iron release.	Iron	116-120	homeostatic iron regulator	Homo sapiens	17-20
12163483-1	2002	The transferrin receptor (TfR) is a transmembrane protein that mediates cellular uptake of iron.	Iron	91-95	transferrin receptor	Homo sapiens	4-24
12163483-1	2002	The transferrin receptor (TfR) is a transmembrane protein that mediates cellular uptake of iron.	Iron	91-95	transferrin receptor	Homo sapiens	26-29
12547227-2	2002	These animals have a defect in the export of iron from intestinal enterocytes into the circulation and this implicates hephaestin in the basolateral transfer step of iron absorption.	Iron	45-49	hephaestin	Mus musculus	119-129
17210810-1	2007	BACKGROUND: Mutations in HFE, a gene defect that can disrupt iron metabolism, have been implicated in increasing the risk of developing amyotrophic lateral sclerosis (ALS).	Iron	61-65	homeostatic iron regulator	Homo sapiens	25-28
12547227-2	2002	These animals have a defect in the export of iron from intestinal enterocytes into the circulation and this implicates hephaestin in the basolateral transfer step of iron absorption.	Iron	166-170	hephaestin	Mus musculus	119-129
12547229-3	2002	In the crypts the cells take up iron from plasma transferrin by receptor-mediated endocytosis, a process that is influenced by the hemochromatosis protein, HFE.	Iron	32-36	homeostatic iron regulator	Rattus norvegicus	156-159
12547229-6	2002	In most experiments the function of the TfR1 was assessed by the uptake of radiolabeled transferrin-bound iron given intravenously.	Iron	106-110	transferrin receptor	Rattus norvegicus	40-44
12547240-1	2002	Transferrin Receptor 1 (TfR1) and putative Stimulator of Fe Transport (SFT) represent two different proteins involved in iron metabolism in mammalian cells.	Iron	121-125	transferrin receptor	Homo sapiens	0-22
12547240-1	2002	Transferrin Receptor 1 (TfR1) and putative Stimulator of Fe Transport (SFT) represent two different proteins involved in iron metabolism in mammalian cells.	Iron	121-125	transferrin receptor	Homo sapiens	24-28
12547240-1	2002	Transferrin Receptor 1 (TfR1) and putative Stimulator of Fe Transport (SFT) represent two different proteins involved in iron metabolism in mammalian cells.	Iron	121-125	ubiquitin conjugating enzyme E2 D1	Homo sapiens	43-69
12547240-1	2002	Transferrin Receptor 1 (TfR1) and putative Stimulator of Fe Transport (SFT) represent two different proteins involved in iron metabolism in mammalian cells.	Iron	121-125	ubiquitin conjugating enzyme E2 D1	Homo sapiens	71-74
12547240-2	2002	The expression of TfR1 in the duodenum of subjects with normal body iron stores has been mainly localized in the basolateral portion of the cytoplasm of crypt cells, supporting the idea that this molecule may be involved in the sensing of body iron stores.	Iron	68-72	transferrin receptor	Homo sapiens	18-22
12547240-2	2002	The expression of TfR1 in the duodenum of subjects with normal body iron stores has been mainly localized in the basolateral portion of the cytoplasm of crypt cells, supporting the idea that this molecule may be involved in the sensing of body iron stores.	Iron	244-248	transferrin receptor	Homo sapiens	18-22
12547240-3	2002	In iron deficiency anemia TfR1 expression demonstrated an inverse relationship with body iron stores as assessed by immunohistochemistry with anti-TfR1 antibodies.	Iron	3-7	transferrin receptor	Homo sapiens	26-30
12547240-4	2002	In iron overload, TfR1 expression in the duodenum differed according to the presence or absence of the C282Y mutation in the HFE gene, being increased in HFE-related hemochromatosis and similar to controls in non-HFE-related iron overload.	Iron	3-7	transferrin receptor	Homo sapiens	18-22
12370409-0	2002	The tomato fer gene encoding a bHLH protein controls iron-uptake responses in roots.	Iron	53-57	bHLH transcriptional regulator	Solanum lycopersicum	11-14
12370409-5	2002	Here, we show that fer plants exhibit root developmental phenotypes after low and sufficient iron nutrition indicating that FER acts irrespective of iron supply.	Iron	93-97	bHLH transcriptional regulator	Solanum lycopersicum	19-22
12370409-5	2002	Here, we show that fer plants exhibit root developmental phenotypes after low and sufficient iron nutrition indicating that FER acts irrespective of iron supply.	Iron	93-97	bHLH transcriptional regulator	Solanum lycopersicum	124-127
12370409-8	2002	fer is expressed in a cell-specific pattern at the root tip independently from iron supply.	Iron	79-83	bHLH transcriptional regulator	Solanum lycopersicum	0-3
12370409-9	2002	Our results suggest that FER may control root physiology and development at a transcriptional level in response to iron supply and thus may be the first identified regulator for iron nutrition in plants.	Iron	115-119	bHLH transcriptional regulator	Solanum lycopersicum	25-28
12370409-9	2002	Our results suggest that FER may control root physiology and development at a transcriptional level in response to iron supply and thus may be the first identified regulator for iron nutrition in plants.	Iron	178-182	bHLH transcriptional regulator	Solanum lycopersicum	25-28
12242109-7	2002	Iron chelation also causes hypophosphorylation of the retinoblastoma protein (pRb) and decreases the expression of cyclins A, B and D, which are vital for cell cycle progression.	Iron	0-4	cyclin A2	Mus musculus	115-133
12547240-4	2002	In iron overload, TfR1 expression in the duodenum differed according to the presence or absence of the C282Y mutation in the HFE gene, being increased in HFE-related hemochromatosis and similar to controls in non-HFE-related iron overload.	Iron	225-229	transferrin receptor	Homo sapiens	18-22
12547240-5	2002	SFT is characterized by its ability to increase iron transport both through the transferrin dependent and independent uptake, and could thus affect iron absorption in the intestine.	Iron	48-52	ubiquitin conjugating enzyme E2 D1	Homo sapiens	0-3
12547240-5	2002	SFT is characterized by its ability to increase iron transport both through the transferrin dependent and independent uptake, and could thus affect iron absorption in the intestine.	Iron	148-152	ubiquitin conjugating enzyme E2 D1	Homo sapiens	0-3
16956324-4	2007	Here, we report the identification of IOP1 (iron-only hydrogenase-like protein 1), a protein homologous with enzymes present in anaerobic organisms that contain a distinctive iron-sulfur cluster.	Iron	44-48	cytosolic iron-sulfur assembly component 3	Homo sapiens	38-42
12547240-8	2002	Thus, the increased expression of both proteins only in patients with HFE-related hemochromatosis suggests that other factors should be involved in determining non-HFE-related iron overload.	Iron	176-180	homeostatic iron regulator	Homo sapiens	70-73
12547240-8	2002	Thus, the increased expression of both proteins only in patients with HFE-related hemochromatosis suggests that other factors should be involved in determining non-HFE-related iron overload.	Iron	176-180	homeostatic iron regulator	Homo sapiens	164-167
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	101-105	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-6
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	101-105	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	8-12
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	171-175	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-6
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	171-175	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	8-12
12416729-3	2002	The function of HFE protein is unknown, but the available evidence suggests that it acts in association with beta2-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	168-172	homeostatic iron regulator	Homo sapiens	16-19
12416729-3	2002	The function of HFE protein is unknown, but the available evidence suggests that it acts in association with beta2-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	258-262	homeostatic iron regulator	Homo sapiens	16-19
12416729-4	2002	The identification of HFE has established the foundation for a better understanding of the molecular and cellular biology of iron homeostasis and its altered regulation in HH.	Iron	125-129	homeostatic iron regulator	Homo sapiens	22-25
12678056-2	2002	Our results show that the C282Y and H63D mutations of the HFE gene associated with hemochromatosis have measurable and consistent effects on iron indicators and are associated with liver disorders, but have no measurable effect on other iron overload-related symptoms and life-expectancy.	Iron	141-145	homeostatic iron regulator	Homo sapiens	58-61
12678056-2	2002	Our results show that the C282Y and H63D mutations of the HFE gene associated with hemochromatosis have measurable and consistent effects on iron indicators and are associated with liver disorders, but have no measurable effect on other iron overload-related symptoms and life-expectancy.	Iron	237-241	homeostatic iron regulator	Homo sapiens	58-61
12416730-4	2002	When cellular iron is abundant, IRPs become inactivated (IRP-1) or degraded (IRP-2).	Iron	14-18	aconitase 1	Homo sapiens	57-62
12416731-3	2002	Most cells possess a ubiquitous system controlling the biosynthesis of TfR at the posttranscriptional level to avoid excess iron influx into the cells through TfR.	Iron	124-128	transferrin receptor	Homo sapiens	71-74
12416731-5	2002	Measurement of serum transferrin receptor is a new marker of iron metabolism that reflects body iron stores and total erythropoiesis.	Iron	61-65	transferrin receptor	Homo sapiens	21-41
12416731-5	2002	Measurement of serum transferrin receptor is a new marker of iron metabolism that reflects body iron stores and total erythropoiesis.	Iron	96-100	transferrin receptor	Homo sapiens	21-41
12377814-0	2002	Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls.	Iron	5-9	homeostatic iron regulator	Homo sapiens	44-47
12377814-0	2002	Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls.	Iron	117-121	homeostatic iron regulator	Homo sapiens	44-47
17241880-9	2007	Levels of the iron-related proteins TfR1, TfR2, ferritin, and prohepcidin were analyzed by immunoblotting.	Iron	14-18	transferrin receptor	Mus musculus	36-40
12377814-1	2002	BACKGROUND AND AIMS: The role of the HFE S65C mutation in the development of hepatic iron overload is unknown.	Iron	85-89	homeostatic iron regulator	Homo sapiens	37-40
12377814-2	2002	The aim of the present study was: (A) to determine the HFE S65C frequency in a Northern European population; and (B) to evaluate whether the presence of the HFE S65C mutation would result in a significant hepatic iron overload.	Iron	213-217	homeostatic iron regulator	Homo sapiens	157-160
12377814-11	2002	The number of iron overloaded patients was significantly higher among those having HFE S65C compared with those without any HFE mutation.	Iron	14-18	homeostatic iron regulator	Homo sapiens	83-86
12377814-11	2002	The number of iron overloaded patients was significantly higher among those having HFE S65C compared with those without any HFE mutation.	Iron	14-18	homeostatic iron regulator	Homo sapiens	124-127
12377814-15	2002	CONCLUSIONS: The HFE S65C mutation may lead to mild to moderate hepatic iron overload but neither clinically manifest haemochromatosis nor iron associated extensive liver fibrosis was encountered in any of the patients carrying this mutation.	Iron	72-76	homeostatic iron regulator	Homo sapiens	17-20
12423242-3	2002	We investigated the binding activity of iron regulatory protein-1 (IRP1) to the iron-responsive element that precludes ferritin mRNA translation, in the substantia nigra of a group of parkinsonian patients who presented a statistically significant reduction in the number of nigral melanized-neurones and an increased iron content, together with unchanged H-ferritin and L-ferritin subunit levels as compared to matched controls.	Iron	40-44	aconitase 1	Homo sapiens	67-71
12423242-3	2002	We investigated the binding activity of iron regulatory protein-1 (IRP1) to the iron-responsive element that precludes ferritin mRNA translation, in the substantia nigra of a group of parkinsonian patients who presented a statistically significant reduction in the number of nigral melanized-neurones and an increased iron content, together with unchanged H-ferritin and L-ferritin subunit levels as compared to matched controls.	Iron	80-84	aconitase 1	Homo sapiens	40-65
12423242-3	2002	We investigated the binding activity of iron regulatory protein-1 (IRP1) to the iron-responsive element that precludes ferritin mRNA translation, in the substantia nigra of a group of parkinsonian patients who presented a statistically significant reduction in the number of nigral melanized-neurones and an increased iron content, together with unchanged H-ferritin and L-ferritin subunit levels as compared to matched controls.	Iron	80-84	aconitase 1	Homo sapiens	67-71
12423242-4	2002	The levels of ferritin mRNAs and the binding activity of IRP1 to the iron-responsive element of ferritin mRNA did not differ significantly between the two groups.	Iron	69-73	aconitase 1	Homo sapiens	57-61
17187402-3	2007	Here, we show that a Cre-loxP-mediated liver-specific disruption of SMAD4 results in markedly decreased hepcidin expression and accumulation of iron in many organs, which is most pronounced in liver, kidney, and pancreas.	Iron	144-148	SMAD family member 4	Homo sapiens	68-73
12237230-0	2002	Deletions in the loop surrounding the iron-sulfur cluster of adrenodoxin severely affect the interactions with its native redox partners adrenodoxin reductase and cytochrome P450(scc) (CYP11A1).	Iron	38-42	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	185-192
12390507-9	2002	As a result, traces of iron salts are capable of catalyzing the conversion of large amounts of BA into ALX.	Iron	23-27	hematopoietic SH2 domain containing	Homo sapiens	103-106
17187402-7	2007	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis [corrected]	Iron	104-108	SMAD family member 4	Homo sapiens	44-49
12163499-0	2002	Iron incorporation into Escherichia coli Dps gives rise to a ferritin-like microcrystalline core.	Iron	0-4	decaprenyl diphosphate synthase subunit 1	Homo sapiens	41-44
12237230-7	2002	In contrast, all mutations in the protein loop influence the binding to the redox partners adrenodoxin reductase (AdR) and cytochrome P450(scc) (CYP11A1) indicating the importance of this loop for the physiological function of this iron--sulfur protein.	Iron	232-236	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	145-152
17187402-7	2007	Our study uncovers a novel role of TGF-beta/SMAD4 in regulating hepcidin expression and thus intestinal iron transport and iron homeostasis [corrected]	Iron	123-127	SMAD family member 4	Homo sapiens	44-49
12163499-4	2002	Since ferritins are endowed with the unique capacity to direct iron deposition toward formation of a microcrystalline core, the structure of iron deposited in the E. coli Dps cavity was studied.	Iron	141-145	decaprenyl diphosphate synthase subunit 1	Homo sapiens	171-174
12163499-5	2002	Polarized single crystal absorption microspectrophotometry of iron-loaded Dps shows that iron ions are oriented.	Iron	62-66	decaprenyl diphosphate synthase subunit 1	Homo sapiens	74-77
17160644-2	2007	Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake.	Iron	104-108	transferrin receptor	Homo sapiens	0-20
12163499-5	2002	Polarized single crystal absorption microspectrophotometry of iron-loaded Dps shows that iron ions are oriented.	Iron	89-93	decaprenyl diphosphate synthase subunit 1	Homo sapiens	74-77
12163499-7	2002	Crystals of iron-loaded Dps also show that, as in mammalian ferritins, iron does not remain bound to the site after oxidation has taken place.	Iron	12-16	decaprenyl diphosphate synthase subunit 1	Homo sapiens	24-27
12163499-7	2002	Crystals of iron-loaded Dps also show that, as in mammalian ferritins, iron does not remain bound to the site after oxidation has taken place.	Iron	71-75	decaprenyl diphosphate synthase subunit 1	Homo sapiens	24-27
12221295-1	2002	Decreased expression of Yfh1p in the budding yeast, Saccharomyces cerevisiae, and the orthologous human gene frataxin results in respiratory deficiency and mitochondrial iron accumulation.	Iron	170-174	frataxin	Homo sapiens	109-117
17160644-2	2007	Transferrin receptor (TfR1) is a type II membrane glycoprotein that, as a cell surface homodimer, binds iron-loaded transferrin as part of the process of iron transfer and uptake.	Iron	104-108	transferrin receptor	Homo sapiens	22-26
12207539-6	2002	Intriguingly, in the Fe-substituted form of MnSOD this identical chemical event occurs at a significantly lower pH.	Iron	21-23	superoxide dismutase 2	Homo sapiens	44-49
12358889-7	2002	The mean HbA2 level rose significantly (from 1.89% +/- 0.45 to 2.19% +/- 0.53, P &lt; 0.001) after iron treatment.	Iron	99-103	hemoglobin subunit alpha 2	Homo sapiens	9-13
17160266-1	2006	Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron intake and progressive storage and is related to mutations in the HFE gene.	Iron	44-48	homeostatic iron regulator	Homo sapiens	158-161
17160266-1	2006	Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron intake and progressive storage and is related to mutations in the HFE gene.	Iron	87-91	homeostatic iron regulator	Homo sapiens	158-161
12210292-4	2002	The correlation between HLA-inferred and HFE genotypes and the variation of serum iron tests according to HFE genotype and other factors were studied in persons from well-characterized hemochromatosis pedigrees.	Iron	82-86	homeostatic iron regulator	Homo sapiens	106-109
17257079-3	2006	Aiming to evaluate further the activity principle of the anticancer effects of this antianemic drug, in this study, we analyzed the utilization of iron from FSC and the effects of FSC iron on transferrin receptor 1 (TfR1) and ferritin expression.	Iron	184-188	transferrin receptor	Homo sapiens	192-214
12198710-5	2002	RESULTS: Iron absorption increased 2.7-fold within 6 days of switching to an iron-deficient diet and was accompanied by an increase in the duodenal expression of Dcytb, divalent metal transporter 1, and Ireg1.	Iron	9-13	cytochrome b reductase 1	Rattus norvegicus	162-167
12198710-5	2002	RESULTS: Iron absorption increased 2.7-fold within 6 days of switching to an iron-deficient diet and was accompanied by an increase in the duodenal expression of Dcytb, divalent metal transporter 1, and Ireg1.	Iron	77-81	cytochrome b reductase 1	Rattus norvegicus	162-167
12361551-0	2002	[Mutations in the HFE gene (C282Y, H63D, S65C) in alcoholic patients with finding of iron overload].	Iron	85-89	homeostatic iron regulator	Homo sapiens	18-21
12361551-4	2002	OBJECTIVE: To analyze whether iron excess among alcoholic individuals is associated with mutations in C282Y, H63D or S65C in the HFE gene.	Iron	30-34	homeostatic iron regulator	Homo sapiens	129-132
17257079-3	2006	Aiming to evaluate further the activity principle of the anticancer effects of this antianemic drug, in this study, we analyzed the utilization of iron from FSC and the effects of FSC iron on transferrin receptor 1 (TfR1) and ferritin expression.	Iron	184-188	transferrin receptor	Homo sapiens	216-220
12364722-2	2002	Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an increased risk for stroke.	Iron	61-65	homeostatic iron regulator	Homo sapiens	12-15
12175942-0	2002	The heme-iron geometry of ferrous nitrosylated heme-serum lipoproteins, hemopexin, and albumin: a comparative EPR study.	Iron	9-13	hemopexin	Homo sapiens	72-81
17168739-4	2006	The iron regulatory proteins (IRPs) have the ability to sense and control the level of intracellular iron by binding to iron responsive elements (IREs) of several genes encoding key proteins such as the transferrin receptor (TfR) and ferritin.	Iron	4-8	transferrin receptor	Homo sapiens	203-223
12149232-2	2002	The mechanism by which HFE regulates iron absorption is not known, but the C282Y mutation results in loss of cell surface expression of the human hemachromatosis protein (HFE) and hyperabsorption of iron by the duodenal enterocyte.	Iron	37-41	homeostatic iron regulator	Homo sapiens	23-26
12149232-2	2002	The mechanism by which HFE regulates iron absorption is not known, but the C282Y mutation results in loss of cell surface expression of the human hemachromatosis protein (HFE) and hyperabsorption of iron by the duodenal enterocyte.	Iron	199-203	homeostatic iron regulator	Homo sapiens	23-26
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	119-123	myelocytomatosis oncogene	Mus musculus	181-184
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	119-123	myelocytomatosis oncogene	Mus musculus	210-213
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	239-243	myelocytomatosis oncogene	Mus musculus	181-184
12165564-2	2002	While frataxin is important for intracellular iron homeostasis, its exact cellular role is unknown.	Iron	46-50	frataxin	Homo sapiens	6-14
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	239-243	myelocytomatosis oncogene	Mus musculus	210-213
17168739-4	2006	The iron regulatory proteins (IRPs) have the ability to sense and control the level of intracellular iron by binding to iron responsive elements (IREs) of several genes encoding key proteins such as the transferrin receptor (TfR) and ferritin.	Iron	4-8	transferrin receptor	Homo sapiens	225-228
12110671-9	2002	These studies reinforce the link between c-Myc and iron regulation and provide further evidence that c-Myc negatively regulates genes that decrease the iron content of the cytosol.	Iron	51-55	myelocytomatosis oncogene	Mus musculus	43-46
12110671-9	2002	These studies reinforce the link between c-Myc and iron regulation and provide further evidence that c-Myc negatively regulates genes that decrease the iron content of the cytosol.	Iron	152-156	myelocytomatosis oncogene	Mus musculus	43-46
17168739-4	2006	The iron regulatory proteins (IRPs) have the ability to sense and control the level of intracellular iron by binding to iron responsive elements (IREs) of several genes encoding key proteins such as the transferrin receptor (TfR) and ferritin.	Iron	101-105	transferrin receptor	Homo sapiens	203-223
12110671-9	2002	These studies reinforce the link between c-Myc and iron regulation and provide further evidence that c-Myc negatively regulates genes that decrease the iron content of the cytosol.	Iron	152-156	myelocytomatosis oncogene	Mus musculus	103-106
17168739-4	2006	The iron regulatory proteins (IRPs) have the ability to sense and control the level of intracellular iron by binding to iron responsive elements (IREs) of several genes encoding key proteins such as the transferrin receptor (TfR) and ferritin.	Iron	101-105	transferrin receptor	Homo sapiens	225-228
12016214-0	2002	Iron and hydrogen peroxide detoxification properties of DNA-binding protein from starved cells.	Iron	0-4	DNA-binding protein	Escherichia coli	56-75
17168739-4	2006	The iron regulatory proteins (IRPs) have the ability to sense and control the level of intracellular iron by binding to iron responsive elements (IREs) of several genes encoding key proteins such as the transferrin receptor (TfR) and ferritin.	Iron	101-105	transferrin receptor	Homo sapiens	203-223
12163393-10	2002	Conversely, squalene synthase (terminal cholesterol synthesis) blockade sensitized HK-2 cells to both Fe and ATP depletion attack.	Iron	102-104	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	12-29
12218443-5	2002	RESULTS: VSOP-C125 is incorporated by cells much faster than DDM 43/34/103 and produces significantly higher final intracellular iron concentrations per cell (3420 vs. 727 ng/million cells).	Iron	129-133	hydrogen voltage gated channel 1	Homo sapiens	9-13
12164868-9	2002	CYP2B1 inhibitors cimetidine and piperine significantly reduced H2O2 generation, and prevented the loss of CYP2B1 content and the increase in the catalytic iron.	Iron	156-160	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	0-6
12196178-4	2002	In hereditary haemochromatosis (HH) accumulation of iron in parenchymal tissues, including the liver, occurs, possibly through dysfunctional IRP1.	Iron	52-56	aconitase 1	Homo sapiens	141-145
12164868-13	2002	CONCLUSION: Our data indicate that CYP2B1 plays an important role in PAN induced NS by serving as a site for ROM generation and a significant source of catalytic iron.	Iron	162-166	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	35-41
17168739-4	2006	The iron regulatory proteins (IRPs) have the ability to sense and control the level of intracellular iron by binding to iron responsive elements (IREs) of several genes encoding key proteins such as the transferrin receptor (TfR) and ferritin.	Iron	101-105	transferrin receptor	Homo sapiens	225-228
12196178-5	2002	Investigation of IRP1 expression in liver biopsies from HH patients showed that the protein is completely absent or markedly reduced in heavily iron-loaded HH patients.	Iron	144-148	aconitase 1	Homo sapiens	17-21
17168739-5	2006	Concurrently, the hypoxia-inducible factor (HIF) has also been shown in previous studies to regulate intracellular iron by binding to HIF-responsive elements (HREs) that are located within the genes of iron-related proteins such as TfR and heme oxygenase-1 (HO-1).	Iron	115-119	transferrin receptor	Homo sapiens	232-235
17168739-5	2006	Concurrently, the hypoxia-inducible factor (HIF) has also been shown in previous studies to regulate intracellular iron by binding to HIF-responsive elements (HREs) that are located within the genes of iron-related proteins such as TfR and heme oxygenase-1 (HO-1).	Iron	202-206	transferrin receptor	Homo sapiens	232-235
17168739-6	2006	This review will focus on the interactions between the IRP/IRE and HIF/HRE systems and how cells utilize these intricate networks to regulate intracellular iron levels.	Iron	156-160	Wnt family member 2	Homo sapiens	55-58
12187081-3	2002	Recently, the soluble transferrin receptor (s-TfR) has been advocated as a parameter of iron status in HD patients.	Iron	88-92	transferrin receptor	Homo sapiens	46-49
12115536-3	2002	Deoxyhypusine hydroxylase, the metalloenzyme catalyzing the final step in hypusine biosynthesis, and prolyl 4-hydroxylase, a non-heme iron enzyme critical for collagen processing, can be inhibited by small chelating molecules that target their essential metal atom.	Iron	134-138	deoxyhypusine hydroxylase/monooxygenase	Gallus gallus	0-25
17115699-0	2006	Circular dichroism and magnetic circular dichroism studies of the active site of p53R2 from human and mouse: iron binding and nature of the biferrous site relative to other ribonucleotide reductases.	Iron	109-113	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	81-86
12121757-3	2002	Current views on cellular iron homeostasis involving the iron regulatory proteins IRP1 and IRP2 and their interactions with the iron regulatory elements, affecting either mRNA translation (ferritin and erythroid cell delta-aminolaevulinate synthase) or mRNA stability (transferrin receptor) are discussed.	Iron	26-30	aconitase 1	Homo sapiens	82-86
12166991-0	2002	Influence of the extent of hemoglobin hydrolysis on the digestive absorption of heme iron.	Iron	85-89	HEME	Bos taurus	80-84
12166991-2	2002	This study was designed to assess the interactions of heme with peptides produced by enzyme hydrolysis of hemoglobin, and their relationship with heme iron absorption.	Iron	151-155	HEME	Bos taurus	54-58
12166991-2	2002	This study was designed to assess the interactions of heme with peptides produced by enzyme hydrolysis of hemoglobin, and their relationship with heme iron absorption.	Iron	151-155	HEME	Bos taurus	146-150
12166991-7	2002	Comparing the products of hydrolysis of the two enzymes showed that heme iron absorption depends not only on its solubility, but relies mainly on the balance between the strength of heme-peptides and the polymerization rate of heme.	Iron	73-77	HEME	Bos taurus	68-72
12121757-3	2002	Current views on cellular iron homeostasis involving the iron regulatory proteins IRP1 and IRP2 and their interactions with the iron regulatory elements, affecting either mRNA translation (ferritin and erythroid cell delta-aminolaevulinate synthase) or mRNA stability (transferrin receptor) are discussed.	Iron	26-30	transferrin receptor	Homo sapiens	269-289
12121757-3	2002	Current views on cellular iron homeostasis involving the iron regulatory proteins IRP1 and IRP2 and their interactions with the iron regulatory elements, affecting either mRNA translation (ferritin and erythroid cell delta-aminolaevulinate synthase) or mRNA stability (transferrin receptor) are discussed.	Iron	57-61	aconitase 1	Homo sapiens	82-86
12121757-3	2002	Current views on cellular iron homeostasis involving the iron regulatory proteins IRP1 and IRP2 and their interactions with the iron regulatory elements, affecting either mRNA translation (ferritin and erythroid cell delta-aminolaevulinate synthase) or mRNA stability (transferrin receptor) are discussed.	Iron	57-61	aconitase 1	Homo sapiens	82-86
12166991-7	2002	Comparing the products of hydrolysis of the two enzymes showed that heme iron absorption depends not only on its solubility, but relies mainly on the balance between the strength of heme-peptides and the polymerization rate of heme.	Iron	73-77	HEME	Bos taurus	182-186
12166991-7	2002	Comparing the products of hydrolysis of the two enzymes showed that heme iron absorption depends not only on its solubility, but relies mainly on the balance between the strength of heme-peptides and the polymerization rate of heme.	Iron	73-77	HEME	Bos taurus	182-186
17115699-6	2006	The active site of biferrous p53R2 in both the human (hp53R2) and mouse (mp53R2) forms is found to have one five-coordinate and one four-coordinate iron, which are weakly antiferromagnetically coupled through mu-1,3-carboxylate bridges.	Iron	148-152	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	29-34
12198371-0	2002	Up-regulation of transferrin receptor expression in hepatocytes by habitual alcohol drinking is implicated in hepatic iron overload in alcoholic liver disease.	Iron	118-122	transferrin receptor	Homo sapiens	17-37
16877034-8	2006	If treatment with the Fe and metal ions was simultaneous (co-treatment), the effects of nickel ion exposure were overwhelmed, since the added Fe reversed HIF-1alpha stabilization, decreased IRP-1 activity, and increased ferritin level.	Iron	22-24	aconitase 1	Homo sapiens	190-195
12198371-4	2002	In this study, to elucidate the mechanism of hepatic iron overload in ALD, we immunohistochemically investigated the expression of transferrin receptor (TfR), which mainly acts for cellular iron uptake.	Iron	53-57	transferrin receptor	Homo sapiens	131-151
12198371-4	2002	In this study, to elucidate the mechanism of hepatic iron overload in ALD, we immunohistochemically investigated the expression of transferrin receptor (TfR), which mainly acts for cellular iron uptake.	Iron	53-57	transferrin receptor	Homo sapiens	153-156
12198371-4	2002	In this study, to elucidate the mechanism of hepatic iron overload in ALD, we immunohistochemically investigated the expression of transferrin receptor (TfR), which mainly acts for cellular iron uptake.	Iron	190-194	transferrin receptor	Homo sapiens	131-151
12198371-4	2002	In this study, to elucidate the mechanism of hepatic iron overload in ALD, we immunohistochemically investigated the expression of transferrin receptor (TfR), which mainly acts for cellular iron uptake.	Iron	190-194	transferrin receptor	Homo sapiens	153-156
12198371-12	2002	CONCLUSIONS: The up-regulation of TfR expression in hepatocytes is implicated in hepatic iron overload in ALD, and habitual alcohol drinking is an important factor for the induction of TfR expression.	Iron	89-93	transferrin receptor	Homo sapiens	34-37
12190182-2	2002	The aim of this study was to compare, in a hospital referral clinic, the reliability of transferrin saturation and UIBC for detection of subjects who have inherited HFE (HLA-asociated iron overload) genotypes predisposing to iron overload.	Iron	184-188	homeostatic iron regulator	Homo sapiens	165-168
12081573-1	2002	BACKGROUND: DMT1 (Nramp2/DCT1) is the major apical iron transporter in absorptive cells of the duodenum, but also transports transferrin-iron across the membrane of acidified endosomes in peripheral tissues.	Iron	51-55	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	12-16
12081573-1	2002	BACKGROUND: DMT1 (Nramp2/DCT1) is the major apical iron transporter in absorptive cells of the duodenum, but also transports transferrin-iron across the membrane of acidified endosomes in peripheral tissues.	Iron	51-55	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	18-24
12081573-1	2002	BACKGROUND: DMT1 (Nramp2/DCT1) is the major apical iron transporter in absorptive cells of the duodenum, but also transports transferrin-iron across the membrane of acidified endosomes in peripheral tissues.	Iron	51-55	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	25-29
12081573-4	2002	Possible regulation of DMT1 protein expression by the body iron stores also was examined in normal mice deprived of dietary iron, and in the genetically anemic mk mice that bear a loss of function mutation at DMT1 (G185R).	Iron	59-63	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	23-27
12081573-5	2002	RESULTS: In microsomal kidney fractions, DMT1 isoform I (encoded by the iron responsive element (IRE)-containing mRNA) is detected as an abundant 70 to 75 kD membrane protein.	Iron	72-76	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	41-45
12190182-2	2002	The aim of this study was to compare, in a hospital referral clinic, the reliability of transferrin saturation and UIBC for detection of subjects who have inherited HFE (HLA-asociated iron overload) genotypes predisposing to iron overload.	Iron	225-229	homeostatic iron regulator	Homo sapiens	165-168
16877034-8	2006	If treatment with the Fe and metal ions was simultaneous (co-treatment), the effects of nickel ion exposure were overwhelmed, since the added Fe reversed HIF-1alpha stabilization, decreased IRP-1 activity, and increased ferritin level.	Iron	142-144	aconitase 1	Homo sapiens	190-195
12006577-0	2002	Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain.	Iron	83-87	frataxin	Homo sapiens	112-120
12070039-3	2002	TfR expression in HD3E22 cells could be modulated by changes in exogenous iron supply, whereas expression in SCF erythroblasts was not subject to iron regulation.	Iron	74-78	transferrin receptor	Gallus gallus	0-3
12070039-5	2002	Changes in mRNA binding activity of iron regulatory protein 1 (IRP1), the primary regulator of TfR mRNA stability in these cells, correlated well with TfR mRNA expression; IRP1 activity in HD3E22 cells and other nonerythroid cell types tested was iron dependent, whereas IRP1 activity in primary SCF erythroblasts could not be modulated by iron administration.	Iron	36-40	transferrin receptor	Gallus gallus	95-98
12070039-5	2002	Changes in mRNA binding activity of iron regulatory protein 1 (IRP1), the primary regulator of TfR mRNA stability in these cells, correlated well with TfR mRNA expression; IRP1 activity in HD3E22 cells and other nonerythroid cell types tested was iron dependent, whereas IRP1 activity in primary SCF erythroblasts could not be modulated by iron administration.	Iron	36-40	transferrin receptor	Gallus gallus	151-154
12070039-5	2002	Changes in mRNA binding activity of iron regulatory protein 1 (IRP1), the primary regulator of TfR mRNA stability in these cells, correlated well with TfR mRNA expression; IRP1 activity in HD3E22 cells and other nonerythroid cell types tested was iron dependent, whereas IRP1 activity in primary SCF erythroblasts could not be modulated by iron administration.	Iron	247-251	transferrin receptor	Gallus gallus	151-154
16904380-2	2006	Iron uptake occurs via the internalization of iron-loaded transferrin (Tf) mediated by the interaction with the TfR.	Iron	0-4	transferrin receptor	Homo sapiens	112-115
16904380-2	2006	Iron uptake occurs via the internalization of iron-loaded transferrin (Tf) mediated by the interaction with the TfR.	Iron	46-50	transferrin receptor	Homo sapiens	112-115
12121511-3	2002	RESULTS: The number of individuals who are at risk of developing increased body iron stores because of HFE mutations is substantially higher (1 in 80) than previously estimated.	Iron	80-84	homeostatic iron regulator	Homo sapiens	103-106
16920030-4	2006	The transferrin receptor (TfR), a cell membrane-associated glycoprotein involved in iron homeostasis and cell growth, has been explored as a target to deliver therapeutics into cancer cells due to its increased expression on malignant cells, accessibility on the cell surface, and constitutive endocytosis.	Iron	84-88	transferrin receptor	Homo sapiens	4-24
12140659-1	2002	We have conducted a case-control study in order to test for an association between 8 intragenic polymorphisms of 5 iron-related genes (transferrin, transferrin receptor1, HFE, frataxin and lactoferrin) and Parkinson disease.	Iron	115-119	homeostatic iron regulator	Homo sapiens	171-174
12140659-1	2002	We have conducted a case-control study in order to test for an association between 8 intragenic polymorphisms of 5 iron-related genes (transferrin, transferrin receptor1, HFE, frataxin and lactoferrin) and Parkinson disease.	Iron	115-119	frataxin	Homo sapiens	176-184
16920030-4	2006	The transferrin receptor (TfR), a cell membrane-associated glycoprotein involved in iron homeostasis and cell growth, has been explored as a target to deliver therapeutics into cancer cells due to its increased expression on malignant cells, accessibility on the cell surface, and constitutive endocytosis.	Iron	84-88	transferrin receptor	Homo sapiens	26-29
16806586-3	2006	The results showed that iron dextran overload increased the iron content in the SN, decreased dopamine release and content, and reduced the numbers of TH-immunoreactive neurons.	Iron	24-28	tyrosine hydroxylase	Rattus norvegicus	151-153
12097675-3	2002	The objective of this study was to investigate whether iron (Fe) deficiency lowers thyroid peroxidase (TPO) activity.	Iron	55-59	thyroid peroxidase	Rattus norvegicus	103-106
12097675-3	2002	The objective of this study was to investigate whether iron (Fe) deficiency lowers thyroid peroxidase (TPO) activity.	Iron	61-63	thyroid peroxidase	Rattus norvegicus	103-106
17373275-1	2006	Since the discovery of HFE gene in 1996, considerable progress has been made concerning the iron-metabolism and its major abnormalities.	Iron	92-96	homeostatic iron regulator	Homo sapiens	23-26
12224755-10	2002	The presence of the IRE provides a binding site for the iron response proteins (IRP1 and 2); binding of either of these proteins could stabilize DMT1 mRNA and would increase expression of the +IRE form of the transporter.	Iron	56-60	aconitase 1	Rattus norvegicus	80-90
17373275-15	2006	Because of the link established between the amount of iron-overload and the occurrence of complications and the mortality over-risk in HFE C282Y +/+ hemochromatosis, venesections must be started when serum ferritin is higher than 300 microg/l in man and 200 microg/l in woman, whatever the clinical manifestations are and obviously before the symptomatic phase of the disease.	Iron	54-58	homeostatic iron regulator	Homo sapiens	135-138
16935420-4	2006	In this study, analyzing the whole coding region of the HFE gene by dHPLC in 278 PD patients, priorly characterized by transcranial sonography for increased iron content of the substantia nigra (SN), we did not find an association of the common HFE mutations and PD.	Iron	157-161	homeostatic iron regulator	Homo sapiens	56-59
12057761-3	2002	A major mechanism for the regulation of iron homeostasis relies on the post-transcriptional control of ferritin and transferrin receptor mRNAs, which are recognized by two cytoplasmic iron regulatory proteins (IRP-1 and IRP-2) that modulate their translation and stability, respectively.	Iron	40-44	aconitase 1	Homo sapiens	210-215
12057761-4	2002	IRP-1 can function as a mRNA binding protein or as an aconitase, depending on whether it disassembles or assembles an iron-sulfur cluster in response to iron deficiency or abundancy, respectively.	Iron	118-122	aconitase 1	Homo sapiens	0-5
12057761-6	2002	Here we briefly review the role of IRP in iron-mediated damage induced by oxygen radicals, nitrogen-centered reactive species, and xenobiotics of pharmacological and clinical interest.	Iron	42-46	Wnt family member 2	Homo sapiens	35-38
16937261-2	2006	Both cadmium and iron are believed to be taken up by duodenal enterocytes via the iron regulated, proton-coupled transporter, DMT1.	Iron	17-21	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	126-130
12055114-1	2002	BACKGROUND: Soluble transferrin receptor (sTfr) is a new marker of iron status and erythropoietic activity.	Iron	67-71	transferrin receptor	Homo sapiens	20-40
16937261-2	2006	Both cadmium and iron are believed to be taken up by duodenal enterocytes via the iron regulated, proton-coupled transporter, DMT1.	Iron	82-86	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	126-130
17061732-0	2006	Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.	Iron	96-100	homeostatic iron regulator	Homo sapiens	44-47
16935936-6	2006	The molecular dynamics simulated structures of the pterin-PAH complexes indicate that 7(S)BH4 inhibition is due to its interaction with the polar region at the pterin binding site close to Ser-251, whereas its low efficiency as cofactor is related to a suboptimal positioning toward the catalytic iron.	Iron	297-301	phenylalanine hydroxylase	Homo sapiens	58-61
16641131-8	2006	RESULTS: Perl"s staining showed increased iron in colorectal cancers, and there was a corresponding overexpression of components of the intracellular iron import machinery (DCYTB, DMT1, and TfR1).	Iron	150-154	transferrin receptor	Homo sapiens	190-194
16988052-7	2006	In contrast, Purkinje neurons and the large neurons in the deep nuclei of Cp-/- mice do not accumulate iron but express high levels of the iron importer divalent metal transporter 1, suggesting that these cells may be iron deprived.	Iron	139-143	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	153-181
16988052-7	2006	In contrast, Purkinje neurons and the large neurons in the deep nuclei of Cp-/- mice do not accumulate iron but express high levels of the iron importer divalent metal transporter 1, suggesting that these cells may be iron deprived.	Iron	139-143	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	153-181
16648237-1	2006	Alveolar macrophages express many proteins important in iron homeostasis, including the iron importer divalent metal transport 1 (DMT1) and the iron exporter ferroportin 1 (FPN1) that likely participate in lung defense.	Iron	56-60	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	130-134
12081573-7	2002	In contrast to the intestine, DMT1 protein expression in kidney is only slightly increased upon deprivation of dietary iron, suggesting different regulation at the two sites.	Iron	119-123	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	30-34
16648237-1	2006	Alveolar macrophages express many proteins important in iron homeostasis, including the iron importer divalent metal transport 1 (DMT1) and the iron exporter ferroportin 1 (FPN1) that likely participate in lung defense.	Iron	88-92	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	130-134
16648237-1	2006	Alveolar macrophages express many proteins important in iron homeostasis, including the iron importer divalent metal transport 1 (DMT1) and the iron exporter ferroportin 1 (FPN1) that likely participate in lung defense.	Iron	88-92	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	130-134
16648237-5	2006	However, iron had no effect on HAMP expression but was able to upregulate both DMT1 and FPN1 in alveolar macrophages.	Iron	9-13	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	79-83
16752077-3	2006	In incubations with MDA-MB-435S.luc cells, the highest iron accumulation was 452.6 pg Fe/cell with LHRH-SPIONs, 203.6 pg Fe/cell with beta-CG-SPIONs and 51.3 pg Fe/cell with SPIONs.	Iron	55-59	gonadotropin releasing hormone 1	Homo sapiens	99-103
12052872-1	2002	Iron regulatory protein 1 (IRP1), a major posttranscriptional regulator of cellular iron and energy metabolism, is controlled by an iron-sulfur cluster switch.	Iron	84-88	aconitase 1	Homo sapiens	0-25
12052872-1	2002	Iron regulatory protein 1 (IRP1), a major posttranscriptional regulator of cellular iron and energy metabolism, is controlled by an iron-sulfur cluster switch.	Iron	84-88	aconitase 1	Homo sapiens	27-31
12052872-1	2002	Iron regulatory protein 1 (IRP1), a major posttranscriptional regulator of cellular iron and energy metabolism, is controlled by an iron-sulfur cluster switch.	Iron	132-136	aconitase 1	Homo sapiens	0-25
12052872-1	2002	Iron regulatory protein 1 (IRP1), a major posttranscriptional regulator of cellular iron and energy metabolism, is controlled by an iron-sulfur cluster switch.	Iron	132-136	aconitase 1	Homo sapiens	27-31
12052872-3	2002	The expression of IRP1(C437S) in cells has been associated with aberrations in iron homeostasis and toxicity.	Iron	79-83	aconitase 1	Homo sapiens	18-22
16752077-3	2006	In incubations with MDA-MB-435S.luc cells, the highest iron accumulation was 452.6 pg Fe/cell with LHRH-SPIONs, 203.6 pg Fe/cell with beta-CG-SPIONs and 51.3 pg Fe/cell with SPIONs.	Iron	86-88	gonadotropin releasing hormone 1	Homo sapiens	99-103
16752077-5	2006	Co-incubation with the same ligands (betaCG or LHRH) decreased the iron accumulation in each case.	Iron	67-71	gonadotropin releasing hormone 1	Homo sapiens	47-51
16856887-4	2006	Transferrin receptor-1 (TfR1) and Ferroportin (FPN) expression was found on the placental syncytiotrophoblast (STB) and were polarised such that TfR1 was on the apical maternal-facing membrane and FPN was on the basal fetal-facing membrane, consistent with unidirectional iron transport from mother to fetus.	Iron	272-276	transferrin receptor	Homo sapiens	0-22
16856887-4	2006	Transferrin receptor-1 (TfR1) and Ferroportin (FPN) expression was found on the placental syncytiotrophoblast (STB) and were polarised such that TfR1 was on the apical maternal-facing membrane and FPN was on the basal fetal-facing membrane, consistent with unidirectional iron transport from mother to fetus.	Iron	272-276	transferrin receptor	Homo sapiens	24-28
16545456-1	2006	Previous studies in this laboratory indicated that manganese (Mn) exposure in vitro increases the expression of transferrin receptor (TfR) by enhancing the binding of iron regulatory proteins (IRPs) to iron responsive element-containing RNA.	Iron	167-171	transferrin receptor	Rattus norvegicus	112-132
16545456-1	2006	Previous studies in this laboratory indicated that manganese (Mn) exposure in vitro increases the expression of transferrin receptor (TfR) by enhancing the binding of iron regulatory proteins (IRPs) to iron responsive element-containing RNA.	Iron	167-171	transferrin receptor	Rattus norvegicus	134-137
16545456-2	2006	The current study further tested the hypothesis that in vivo exposure to Mn increased TfR expression at both blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier (BCB), which contributes to altered iron (Fe) homeostasis in the CSF.	Iron	215-219	transferrin receptor	Rattus norvegicus	86-89
16545456-2	2006	The current study further tested the hypothesis that in vivo exposure to Mn increased TfR expression at both blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier (BCB), which contributes to altered iron (Fe) homeostasis in the CSF.	Iron	221-223	transferrin receptor	Rattus norvegicus	86-89
16545456-6	2006	Gel shift assay showed that Mn caused a dose-dependent increase of binding of IRP1 to iron responsive element-containing RNA in BCB in the choroid plexus (+70%), in regional BBB of capillaries of striatum (+39%), hippocampus (+56%), frontal cortex (+49%), and in brain parenchyma of striatum (+67%), hippocampus (+39%) and cerebellum (+28%).	Iron	86-90	aconitase 1	Rattus norvegicus	78-82
17101455-2	2006	The signs and symptoms of the disorder derive from decreased expression of the protein frataxin, which is involved in iron metabolism.	Iron	118-122	frataxin	Homo sapiens	87-95
17101455-3	2006	Frataxin chaperones iron for iron-sulfur cluster biogenesis and detoxifies iron in the mitochondrial matrix.	Iron	20-24	frataxin	Homo sapiens	0-8
17101455-3	2006	Frataxin chaperones iron for iron-sulfur cluster biogenesis and detoxifies iron in the mitochondrial matrix.	Iron	29-33	frataxin	Homo sapiens	0-8
17101455-3	2006	Frataxin chaperones iron for iron-sulfur cluster biogenesis and detoxifies iron in the mitochondrial matrix.	Iron	29-33	frataxin	Homo sapiens	0-8
17101455-4	2006	Decreased expression of frataxin is associated with impairments of iron-sulfur cluster biogenesis and heme synthesis, as well as with mitochondrial dysfunction and oxidative stress.	Iron	67-71	frataxin	Homo sapiens	24-32
17101455-6	2006	Iron chelators and compounds that increase frataxin expression are under evaluation.	Iron	0-4	frataxin	Homo sapiens	43-51
16893190-1	2006	Heme-regulated eIF2alpha kinase [heme-regulated inhibitor (HRI)] plays a critical role in the regulation of protein synthesis by heme iron.	Iron	134-138	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	33-57
16893190-1	2006	Heme-regulated eIF2alpha kinase [heme-regulated inhibitor (HRI)] plays a critical role in the regulation of protein synthesis by heme iron.	Iron	134-138	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	59-62
16847322-0	2006	Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation.	Iron	46-50	NFS1 cysteine desulfurase	Homo sapiens	28-32
16847322-0	2006	Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation.	Iron	81-85	NFS1 cysteine desulfurase	Homo sapiens	28-32
16847322-11	2006	The results have implications for the regulation of iron homeostasis by cytosolic iron regulatory protein 1.	Iron	52-56	aconitase 1	Homo sapiens	82-107
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	119-123	lipocalin 2	Mus musculus	247-258
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	151-155	lipocalin 2	Mus musculus	247-258
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	151-155	lipocalin 2	Mus musculus	247-258
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	151-155	lipocalin 2	Mus musculus	247-258
16764889-3	2006	Most FRDA patients have expanded GAA*TTC repeats (up to 1700 triplets), which inhibit the transcription of the gene, thus diminishing the synthesis of frataxin, a mitochondrial protein involved in iron-sulfur cluster biogenesis.	Iron	197-201	frataxin	Homo sapiens	5-9
16764889-3	2006	Most FRDA patients have expanded GAA*TTC repeats (up to 1700 triplets), which inhibit the transcription of the gene, thus diminishing the synthesis of frataxin, a mitochondrial protein involved in iron-sulfur cluster biogenesis.	Iron	197-201	frataxin	Homo sapiens	151-159
16828895-9	2006	SOD2 can also bind iron in vivo, but is inactive with iron.	Iron	19-23	superoxide dismutase 2	Homo sapiens	0-4
12076669-2	2002	Loss of frataxin causes mitochondrial iron accumulation, deficiency in the activities of iron-sulfur (Fe-S) proteins, and increased oxidative stress.	Iron	38-42	frataxin	Homo sapiens	8-16
12076669-2	2002	Loss of frataxin causes mitochondrial iron accumulation, deficiency in the activities of iron-sulfur (Fe-S) proteins, and increased oxidative stress.	Iron	89-93	frataxin	Homo sapiens	8-16
12076669-2	2002	Loss of frataxin causes mitochondrial iron accumulation, deficiency in the activities of iron-sulfur (Fe-S) proteins, and increased oxidative stress.	Iron	102-106	frataxin	Homo sapiens	8-16
16787441-2	2006	Heme oxygenase consists of two structurally related isozymes, heme oxygenase-1 and and heme oxygenase-2, each of which cleaves heme to form biliverdin, iron and carbon monoxide.	Iron	152-156	heme oxygenase 2	Homo sapiens	87-103
12076669-5	2002	These results taken together suggest that frataxin may function either in mitochondrial iron homeostasis, in Fe-S cluster biogenesis, or directly in the response to oxidative stress.	Iron	88-92	frataxin	Homo sapiens	42-50
12076669-5	2002	These results taken together suggest that frataxin may function either in mitochondrial iron homeostasis, in Fe-S cluster biogenesis, or directly in the response to oxidative stress.	Iron	109-111	frataxin	Homo sapiens	42-50
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	8-12	transferrin receptor	Homo sapiens	152-156
12243984-2	2002	It does this via iron regulatory proteins (IRPs) which bind reversibly to the iron responsive elements (IREs) on the mRNA of transferrin receptor (TfR), erythroid 5-aminolaevulinic acid synthase (ALA-S2) and ferritin.	Iron	17-21	transferrin receptor	Homo sapiens	125-145
12243984-2	2002	It does this via iron regulatory proteins (IRPs) which bind reversibly to the iron responsive elements (IREs) on the mRNA of transferrin receptor (TfR), erythroid 5-aminolaevulinic acid synthase (ALA-S2) and ferritin.	Iron	17-21	transferrin receptor	Homo sapiens	147-150
12243984-2	2002	It does this via iron regulatory proteins (IRPs) which bind reversibly to the iron responsive elements (IREs) on the mRNA of transferrin receptor (TfR), erythroid 5-aminolaevulinic acid synthase (ALA-S2) and ferritin.	Iron	17-21	5'-aminolevulinate synthase 2	Homo sapiens	196-202
12243984-2	2002	It does this via iron regulatory proteins (IRPs) which bind reversibly to the iron responsive elements (IREs) on the mRNA of transferrin receptor (TfR), erythroid 5-aminolaevulinic acid synthase (ALA-S2) and ferritin.	Iron	78-82	transferrin receptor	Homo sapiens	125-145
12243984-2	2002	It does this via iron regulatory proteins (IRPs) which bind reversibly to the iron responsive elements (IREs) on the mRNA of transferrin receptor (TfR), erythroid 5-aminolaevulinic acid synthase (ALA-S2) and ferritin.	Iron	78-82	transferrin receptor	Homo sapiens	147-150
12243984-2	2002	It does this via iron regulatory proteins (IRPs) which bind reversibly to the iron responsive elements (IREs) on the mRNA of transferrin receptor (TfR), erythroid 5-aminolaevulinic acid synthase (ALA-S2) and ferritin.	Iron	78-82	5'-aminolevulinate synthase 2	Homo sapiens	196-202
12090619-6	2002	Reduced glutathione (GSH), which plays an important role in activating the ROI signal transduction pathway as well as in ROI detoxification, was found to enhance the induction of APX mRNA by iron.	Iron	191-195	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	179-182
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	118-122	transferrin receptor	Homo sapiens	152-156
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	13-17	Wnt family member 2	Homo sapiens	176-199
11986241-10	2002	Significantly, protoporphyrin IX down-regulates frataxin protein levels, suggesting a regulatory role of frataxin in Fe or heme metabolism.	Iron	117-119	frataxin	Homo sapiens	48-56
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	13-17	Wnt family member 2	Homo sapiens	201-204
11986241-10	2002	Significantly, protoporphyrin IX down-regulates frataxin protein levels, suggesting a regulatory role of frataxin in Fe or heme metabolism.	Iron	117-119	frataxin	Homo sapiens	105-113
11986241-11	2002	Because decreased frataxin expression leads to mitochondrial Fe loading in FA, our data suggest that reduced frataxin expression during erythroid differentiation results in mitochondrial Fe sequestration for heme biosynthesis.	Iron	61-63	frataxin	Homo sapiens	18-26
12112242-1	2002	When S. cerevisiae are grown with glucose, SDH2 mRNA encoding the iron protein of the succinate dehydrogenase complex is unstable and present at low level.	Iron	66-70	succinate dehydrogenase iron-sulfur protein subunit SDH2	Saccharomyces cerevisiae S288C	43-47
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	104-108	Wnt family member 2	Homo sapiens	176-199
11986241-11	2002	Because decreased frataxin expression leads to mitochondrial Fe loading in FA, our data suggest that reduced frataxin expression during erythroid differentiation results in mitochondrial Fe sequestration for heme biosynthesis.	Iron	61-63	frataxin	Homo sapiens	109-117
11986241-11	2002	Because decreased frataxin expression leads to mitochondrial Fe loading in FA, our data suggest that reduced frataxin expression during erythroid differentiation results in mitochondrial Fe sequestration for heme biosynthesis.	Iron	187-189	frataxin	Homo sapiens	109-117
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	104-108	Wnt family member 2	Homo sapiens	201-204
16624412-5	2006	This finding suggests that the position of the two propionates as well as the symmetry of the porphycene framework is an important factor for obtaining a stable oxygenated iron porphycene myoglobin.	Iron	172-176	myoglobin	Physeter catodon	188-197
11977179-0	2002	ABCB6 (MTABC3) excluded as the causative gene for the growth retardation syndrome with aminoaciduria, cholestasis, iron overload, and lactacidosis.	Iron	115-119	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-5
11977179-0	2002	ABCB6 (MTABC3) excluded as the causative gene for the growth retardation syndrome with aminoaciduria, cholestasis, iron overload, and lactacidosis.	Iron	115-119	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	7-13
11977179-4	2002	The ABCB6 gene, involved in iron homeostasis, mitochondrial respiratory function, and maintenance of the stability of mitochondrial DNA, has been positioned to this same chromosomal region, and advocated in literature as a highly probable candidate gene for the syndrome on both functional and positional grounds.	Iron	28-32	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	4-9
12010659-0	2002	High prevalence of a screening-detected, HFE-unrelated, mild idiopathic iron overload in Northern Italy.	Iron	72-76	homeostatic iron regulator	Homo sapiens	41-44
12010659-8	2002	Pedigree analysis excluded linkage of heterozygous HFE mutations with iron overload (cumulative lod score 2.41) and documented a recessive non-HLA-linked locus accounting for iron overload in wild type/wild type genotypes.	Iron	70-74	homeostatic iron regulator	Homo sapiens	51-54
12010659-10	2002	INTERPRETATION AND CONCLUSIONS: In Northern Italy an HFE-unrelated, mild idiopathic iron overload is highly prevalent.	Iron	84-88	homeostatic iron regulator	Homo sapiens	53-56
12401305-4	2002	There is no evidence to suggest that current dietary changes will have a major impact on iron status in the general population; however, effects on the incidence of iron overload in individuals with HFE mutations and iron deficiency in children and premenopausal women remain to be determined.	Iron	165-169	homeostatic iron regulator	Homo sapiens	199-202
12401308-14	2002	Non-HFE related inherited iron overload may be due to mutations in other iron related genes.	Iron	26-30	homeostatic iron regulator	Homo sapiens	4-7
12401308-14	2002	Non-HFE related inherited iron overload may be due to mutations in other iron related genes.	Iron	73-77	homeostatic iron regulator	Homo sapiens	4-7
12401309-5	2002	Population studies have revealed (i) the serum transferrin saturation is strongly influenced by HFE genotype, being lowest in subjects lacking mutations and highest in those homozygous for C282Y; (ii) most subjects homozygous for C282Y accumulate iron but do not present with the clinical manifestations of iron overload.	Iron	247-251	homeostatic iron regulator	Homo sapiens	96-99
12401309-5	2002	Population studies have revealed (i) the serum transferrin saturation is strongly influenced by HFE genotype, being lowest in subjects lacking mutations and highest in those homozygous for C282Y; (ii) most subjects homozygous for C282Y accumulate iron but do not present with the clinical manifestations of iron overload.	Iron	307-311	homeostatic iron regulator	Homo sapiens	96-99
11964145-0	2002	Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element.	Iron	43-47	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	60-66
11991850-4	2002	This article outlines the current state of knowledge on cellular iron homeostasis, with particular reference to the iron regulatory proteins (IRP1, IRP2 and HFE) and the iron membrane transport proteins, two of which have been shown to be members of the natural resistance- associated macrophage protein family (Nramp1 and 2).	Iron	65-69	aconitase 1	Homo sapiens	142-146
11991850-4	2002	This article outlines the current state of knowledge on cellular iron homeostasis, with particular reference to the iron regulatory proteins (IRP1, IRP2 and HFE) and the iron membrane transport proteins, two of which have been shown to be members of the natural resistance- associated macrophage protein family (Nramp1 and 2).	Iron	65-69	homeostatic iron regulator	Homo sapiens	157-160
11991850-4	2002	This article outlines the current state of knowledge on cellular iron homeostasis, with particular reference to the iron regulatory proteins (IRP1, IRP2 and HFE) and the iron membrane transport proteins, two of which have been shown to be members of the natural resistance- associated macrophage protein family (Nramp1 and 2).	Iron	116-120	aconitase 1	Homo sapiens	142-146
11991850-4	2002	This article outlines the current state of knowledge on cellular iron homeostasis, with particular reference to the iron regulatory proteins (IRP1, IRP2 and HFE) and the iron membrane transport proteins, two of which have been shown to be members of the natural resistance- associated macrophage protein family (Nramp1 and 2).	Iron	116-120	aconitase 1	Homo sapiens	142-146
11933019-2	2002	However, it was not until recently with the identification and characterization of several new genes related to iron homeostasis, such as the hemochromatosis protein HFE and the iron transporter DMT1, that our knowledge has been advanced dramatically.	Iron	112-116	homeostatic iron regulator	Homo sapiens	166-169
11933019-3	2002	A major pathway for cellular iron uptake is through internalization of the complex of iron-bound transferrin and the transferrin receptor, which is negatively modulated by HFE, a protein related to hereditary hemochromatosis.	Iron	29-33	homeostatic iron regulator	Homo sapiens	172-175
11933019-3	2002	A major pathway for cellular iron uptake is through internalization of the complex of iron-bound transferrin and the transferrin receptor, which is negatively modulated by HFE, a protein related to hereditary hemochromatosis.	Iron	86-90	homeostatic iron regulator	Homo sapiens	172-175
11933021-2	2002	Nonsteroidal aromatase inhibitors (NSAIs) are competitive inhibitors of aromatase, which bind to the enzyme active site by coordinating the iron atom present in the heme group of the P450 protein.	Iron	140-144	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	183-187
12030278-1	2002	Studies of the molecular function of HFE, the protein defective in hereditary hemochromatosis, have provided important insights into the control of intestinal iron absorption.	Iron	159-163	homeostatic iron regulator	Homo sapiens	37-40
12030278-2	2002	A recent study suggests that HFE controls the recycling rate of the transferrin receptor and thereby ultimately controls the iron status of the enterocyte.	Iron	125-129	homeostatic iron regulator	Homo sapiens	29-32
12030278-2	2002	A recent study suggests that HFE controls the recycling rate of the transferrin receptor and thereby ultimately controls the iron status of the enterocyte.	Iron	125-129	transferrin receptor	Homo sapiens	68-88
12030278-3	2002	In hereditary hemochromatosis, a defect in HFE causes relative iron starvation in the enterocyte leading paradoxically to the development of an "anemic" enterocyte phenotype in the midst of bountiful body iron stores.	Iron	63-67	homeostatic iron regulator	Homo sapiens	43-46
12030278-3	2002	In hereditary hemochromatosis, a defect in HFE causes relative iron starvation in the enterocyte leading paradoxically to the development of an "anemic" enterocyte phenotype in the midst of bountiful body iron stores.	Iron	205-209	homeostatic iron regulator	Homo sapiens	43-46
11954010-6	2002	The efficiency of erythroblast surface TfR function for Tf-iron uptake was determined by relating total iron uptake at 4 hours to surface TfR number.	Iron	59-63	transferrin receptor	Homo sapiens	39-42
11954010-6	2002	The efficiency of erythroblast surface TfR function for Tf-iron uptake was determined by relating total iron uptake at 4 hours to surface TfR number.	Iron	59-63	transferrin receptor	Homo sapiens	138-141
11954010-6	2002	The efficiency of erythroblast surface TfR function for Tf-iron uptake was determined by relating total iron uptake at 4 hours to surface TfR number.	Iron	104-108	transferrin receptor	Homo sapiens	39-42
11954010-11	2002	This increase was not associated with an increase in surface TfR expression (P = 0.5), but was seen to occur as a result of a significant increase in the efficiency of surface TfR for Tf-iron uptake (P = 0.027).	Iron	187-191	transferrin receptor	Homo sapiens	176-179
11954010-13	2002	This additional erythroblast response to absent RE iron stores led to a highly significant difference in serum sTfR values between RA-IDA and RA-ACD (40.2 +/- 14.0 versus 23.9 +/- 5.3 nmoles/liter; P = 0.001) CONCLUSIONS: An increase in erythroblast surface TfR efficiency for Tf-iron uptake compensates for the low plasma iron levels associated with anemia in RA and helps to maintain RA erythroblast iron uptake.	Iron	51-55	transferrin receptor	Homo sapiens	112-115
11954010-14	2002	With adequate RE iron stores, this increased efficiency limits intracellular iron deprivation and consequently reduces the need to increase surface TfR expression.	Iron	17-21	transferrin receptor	Homo sapiens	148-151
11954010-14	2002	With adequate RE iron stores, this increased efficiency limits intracellular iron deprivation and consequently reduces the need to increase surface TfR expression.	Iron	77-81	transferrin receptor	Homo sapiens	148-151
11812787-4	2002	Although iron-free iron regulatory protein 1 displays a significantly larger radius of gyration measured by small-angle neutron scattering than calculated for mitochondrial aconitase, binding of either the [4Fe-4S] cluster needed for aconitase activity or of a RNA substrate turns iron regulatory protein 1 into a more compact molecule.	Iron	9-13	aconitase 1	Homo sapiens	19-44
11812787-4	2002	Although iron-free iron regulatory protein 1 displays a significantly larger radius of gyration measured by small-angle neutron scattering than calculated for mitochondrial aconitase, binding of either the [4Fe-4S] cluster needed for aconitase activity or of a RNA substrate turns iron regulatory protein 1 into a more compact molecule.	Iron	9-13	aconitase 1	Homo sapiens	281-306
11812787-7	2002	These studies refine previously proposed models of the "iron-sulfur switch" driving the biological function of human iron regulatory protein 1, and they provide a structural framework to probe the relevance of the numerous cellular molecules proposed to affect its function.	Iron	56-60	aconitase 1	Homo sapiens	117-142
11934617-2	2002	Some bacteria also use iron in heme, hemoglobin, hemopexin, transferrin and lactoferrin of eukaryotic hosts.	Iron	23-27	hemopexin	Homo sapiens	49-58
12042069-4	2002	The binding strength between heme and HPX, and the presence of a specific heme-HPX receptor able to catabolize the complex and to induce intracellular antioxidant activities, suggest that hemopexin is the major vehicle for the transportation of heme in the plasma, thus preventing heme-mediated oxidative stress and heme-bound iron loss.	Iron	327-331	hemopexin	Homo sapiens	79-82
12042069-4	2002	The binding strength between heme and HPX, and the presence of a specific heme-HPX receptor able to catabolize the complex and to induce intracellular antioxidant activities, suggest that hemopexin is the major vehicle for the transportation of heme in the plasma, thus preventing heme-mediated oxidative stress and heme-bound iron loss.	Iron	327-331	hemopexin	Homo sapiens	188-197
12042069-5	2002	In this review, we discuss the experimental data that support this view and show that the most important physiological role of HPX is to act as an antioxidant after blood heme overload, rather than to participate in iron metabolism.	Iron	216-220	hemopexin	Homo sapiens	127-130
11925462-5	2002	Exposure of the cells to iron (200 micromol/L ferric nitrilotriacetic acid for 72 h) significantly decreased transferrin receptor mRNA (80%), DMT1 mRNA (57%) and IREG1 mRNA (52%).	Iron	25-29	transferrin receptor	Homo sapiens	109-129
12064861-2	2002	Laboratory studies supported a diagnosis of porphyria cutanea tarda, complicated by the presence of both the C282Y and H63D mutations in the HFE gene, with susequent iron over-load.	Iron	166-170	homeostatic iron regulator	Homo sapiens	141-144
12064862-3	2002	Recently, other less common hereditary forms of iron overload have been recognized and are designated as non-HFE-related HH.	Iron	48-52	homeostatic iron regulator	Homo sapiens	109-112
12064862-4	2002	The identification and cloning of HFE and other genes involved in iron metabolism has greatly expanded our understanding of many aspects of HH.	Iron	66-70	homeostatic iron regulator	Homo sapiens	34-37
12007648-1	2002	We demonstrated earlier that hemin-iron-containing compounds which include hemin, human hemoglobin, bovine hemoglobin, and bovine catalase stimulate the growth of Prevotella intermedia [Leung, Subramaniam, Okamoto, Fukushima, Lai, FEMS Microbiol.	Iron	35-39	catalase	Bos taurus	130-138
11841990-4	2002	Hereditary hemochromatosis, the prototype of deregulated iron homeostasis in humans, is due to inappropriately increased iron absorption and is commonly associated to a mutated HFE gene.	Iron	57-61	homeostatic iron regulator	Homo sapiens	177-180
11841990-5	2002	The HFE protein is homologous to major histocompatibility complex class I proteins but is not an iron carrier, whereas biochemical and cell biological studies have shown that the transferrin receptor, the main protein devoted to cellular uptake of transferrin iron, interacts with HFE.	Iron	260-264	homeostatic iron regulator	Homo sapiens	4-7
11841990-6	2002	This review focuses on recent advances in iron research and presents a model of HFE function in iron metabolism.	Iron	42-46	homeostatic iron regulator	Homo sapiens	80-83
11841990-6	2002	This review focuses on recent advances in iron research and presents a model of HFE function in iron metabolism.	Iron	96-100	homeostatic iron regulator	Homo sapiens	80-83
12064915-0	2002	Polymorphisms in the 5" flanking region of the HFE gene: linkage disequilibrium and relationship to iron homeostasis.	Iron	100-104	homeostatic iron regulator	Homo sapiens	47-50
12068795-4	2002	Another study population consisted of 95 hospital patients of whom 31 had depleted iron stores according to TfR concentration.	Iron	83-87	transferrin receptor	Homo sapiens	108-111
11875007-5	2002	In DBA/2 Hfe-/- mice, increased intestinal iron absorption results from the concomitant up-regulation of the Dcytb, DMT1, and FPN1 messengers.	Iron	43-47	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	116-120
12002748-1	2002	The gene causing hereditary hemochromatosis (HH), HFE is an HLA class I-like gene with no known immunological function but indirectly related to the immune functions because of its role in iron transport.	Iron	189-193	homeostatic iron regulator	Homo sapiens	50-53
11847294-3	2002	Although zinc beta-lactamases contain either a mono or a di-zinc center, the catalytically active form of glyoxalase II contains a mixed iron-zinc binuclear center, whereas A-type flavoproteins contain a di-iron site.	Iron	137-141	hydroxyacylglutathione hydrolase	Homo sapiens	106-119
11960684-1	2002	The human transferrin receptor (TfR) and its ligand, the serum iron carrier transferrin, serve as a model system for endocytic receptors.	Iron	63-67	transferrin receptor	Homo sapiens	10-30
11827525-2	2002	ACS contains an active site nickel iron-sulfur cluster that forms a paramagnetic adduct with CO, called the nickel iron carbon (NiFeC) species, which we have hypothesized to be a key intermediate in acetyl-CoA synthesis.	Iron	35-39	acyl-CoA synthetase short chain family member 2	Homo sapiens	0-3
16784228-0	2006	Monomeric yeast frataxin is an iron-binding protein.	Iron	31-35	frataxin	Homo sapiens	16-24
16784228-2	2006	Although frataxin is nuclear-encoded, it is targeted to the mitochondrial matrix and necessary for proper regulation of cellular iron homeostasis.	Iron	129-133	frataxin	Homo sapiens	9-17
16784228-3	2006	Frataxin is required for the cellular production of both heme and iron-sulfur (Fe-S) clusters.	Iron	79-83	frataxin	Homo sapiens	0-8
16784228-4	2006	Monomeric frataxin binds with high affinity to ferrochelatase, the enzyme involved in iron insertion into porphyrin during heme production.	Iron	86-90	frataxin	Homo sapiens	10-18
16784228-5	2006	Monomeric frataxin also binds to Isu, the scaffold protein required for assembly of Fe-S cluster intermediates.	Iron	84-88	frataxin	Homo sapiens	10-18
16784228-6	2006	These processes (heme and Fe-S cluster assembly) share requirements for iron, suggesting that monomeric frataxin might function as the common iron donor.	Iron	26-28	frataxin	Homo sapiens	104-112
16784228-6	2006	These processes (heme and Fe-S cluster assembly) share requirements for iron, suggesting that monomeric frataxin might function as the common iron donor.	Iron	72-76	frataxin	Homo sapiens	104-112
16784228-6	2006	These processes (heme and Fe-S cluster assembly) share requirements for iron, suggesting that monomeric frataxin might function as the common iron donor.	Iron	142-146	frataxin	Homo sapiens	104-112
16784228-7	2006	To provide a molecular basis to better understand frataxin"s function, we have characterized the binding properties and metal-site structure of ferrous iron bound to monomeric yeast frataxin.	Iron	144-156	frataxin	Homo sapiens	50-58
16784228-7	2006	To provide a molecular basis to better understand frataxin"s function, we have characterized the binding properties and metal-site structure of ferrous iron bound to monomeric yeast frataxin.	Iron	144-156	frataxin	Homo sapiens	182-190
16784228-8	2006	Yeast frataxin is stable as an iron-loaded monomer, and the protein can bind two ferrous iron atoms with micromolar binding affinity.	Iron	31-35	frataxin	Homo sapiens	6-14
16784228-8	2006	Yeast frataxin is stable as an iron-loaded monomer, and the protein can bind two ferrous iron atoms with micromolar binding affinity.	Iron	89-93	frataxin	Homo sapiens	6-14
16784228-9	2006	Frataxin amino acids affected by the presence of iron are localized within conserved acidic patches located on the surfaces of both helix-1 and strand-1.	Iron	49-53	frataxin	Homo sapiens	0-8
16784228-12	2006	On the basis of our results, we have developed a model for how we believe yeast frataxin interacts with iron.	Iron	104-108	frataxin	Homo sapiens	80-88
16603772-0	2006	Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.	Iron	0-4	frataxin	Homo sapiens	71-75
16603772-0	2006	Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.	Iron	82-86	frataxin	Homo sapiens	71-75
16603772-4	2006	CyaY, the bacterial ortholog of frataxin, an iron binding protein thought to be involved in iron-sulfur cluster formation in eukaryotes, is a good candidate because it was shown to bind iron.	Iron	45-49	frataxin	Homo sapiens	0-4
16603772-4	2006	CyaY, the bacterial ortholog of frataxin, an iron binding protein thought to be involved in iron-sulfur cluster formation in eukaryotes, is a good candidate because it was shown to bind iron.	Iron	45-49	frataxin	Homo sapiens	32-40
16603772-4	2006	CyaY, the bacterial ortholog of frataxin, an iron binding protein thought to be involved in iron-sulfur cluster formation in eukaryotes, is a good candidate because it was shown to bind iron.	Iron	92-96	frataxin	Homo sapiens	0-4
16603772-4	2006	CyaY, the bacterial ortholog of frataxin, an iron binding protein thought to be involved in iron-sulfur cluster formation in eukaryotes, is a good candidate because it was shown to bind iron.	Iron	92-96	frataxin	Homo sapiens	32-40
16603772-4	2006	CyaY, the bacterial ortholog of frataxin, an iron binding protein thought to be involved in iron-sulfur cluster formation in eukaryotes, is a good candidate because it was shown to bind iron.	Iron	92-96	frataxin	Homo sapiens	0-4
16603772-4	2006	CyaY, the bacterial ortholog of frataxin, an iron binding protein thought to be involved in iron-sulfur cluster formation in eukaryotes, is a good candidate because it was shown to bind iron.	Iron	92-96	frataxin	Homo sapiens	32-40
16603772-5	2006	Nevertheless, no functional in vitro studies showing an involvement of CyaY in [Fe-S] cluster biosynthesis have been reported so far.	Iron	80-84	frataxin	Homo sapiens	71-75
16603772-6	2006	In this paper we demonstrate for the first time a specific interaction between CyaY and IscS, a cysteine desulfurase participating in iron-sulfur cluster assembly.	Iron	134-138	frataxin	Homo sapiens	79-83
16603772-6	2006	In this paper we demonstrate for the first time a specific interaction between CyaY and IscS, a cysteine desulfurase participating in iron-sulfur cluster assembly.	Iron	134-138	NFS1 cysteine desulfurase	Homo sapiens	88-92
16603772-10	2006	All of these results point toward a link between CyaY and [Fe-S] cluster biosynthesis, and a possible mechanism for the process is discussed.	Iron	59-63	frataxin	Homo sapiens	49-53
16731299-1	2006	BACKGROUND: The diagnostic power of the transferrin receptor-ferritin (TfR-F) index for identification of iron responsiveness in long-term hemodialysis (HD) patients compared with the routine markers recommended by the current US and European guidelines was appraised.	Iron	106-110	transferrin receptor	Homo sapiens	71-74
16731299-12	2006	Our study indicates that TfR-F index is a new and surrogate marker to estimate body iron stores and guide IVFE therapy for long-term HD patients.	Iron	84-88	transferrin receptor	Homo sapiens	25-28
16802872-5	2006	This occurred because iron ions produce DNA fragments smaller than 0.75 Mbp with a higher probability than gamma rays (a probability that increases with LET).	Iron	22-26	myelin basic protein	Homo sapiens	72-75
16700543-0	2006	Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane.	Iron	13-17	ferroxidase FET3	Saccharomyces cerevisiae S288C	36-41
16700543-0	2006	Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane.	Iron	62-66	ferroxidase FET3	Saccharomyces cerevisiae S288C	36-41
16700543-1	2006	In high-affinity iron uptake in the yeast Saccharomyces cerevisiae, Fe(II) is oxidized to Fe(III) by the multicopper oxidase, Fet3p, and the Fe(III) produced is transported into the cell via the iron permease, Ftr1p.	Iron	17-21	ferroxidase FET3	Saccharomyces cerevisiae S288C	126-131
16700543-1	2006	In high-affinity iron uptake in the yeast Saccharomyces cerevisiae, Fe(II) is oxidized to Fe(III) by the multicopper oxidase, Fet3p, and the Fe(III) produced is transported into the cell via the iron permease, Ftr1p.	Iron	195-199	ferroxidase FET3	Saccharomyces cerevisiae S288C	126-131
16700543-4	2006	We examine the (59)Fe uptake kinetics for a number of complexes containing mutant forms of both Fet3p and Ftr1p and demonstrate that a residue in one protein interacts with one in the other protein along the iron trafficking pathway as would be expected in a channeling process.	Iron	19-21	ferroxidase FET3	Saccharomyces cerevisiae S288C	96-101
16700543-4	2006	We examine the (59)Fe uptake kinetics for a number of complexes containing mutant forms of both Fet3p and Ftr1p and demonstrate that a residue in one protein interacts with one in the other protein along the iron trafficking pathway as would be expected in a channeling process.	Iron	208-212	ferroxidase FET3	Saccharomyces cerevisiae S288C	96-101
16678024-8	2006	The increased risk of skin lesion and the early age of onset of the disease in HFE carriers confirm in a clinical setting that intracellular iron deposits of mutated macrophages have less stability than those of the wild type.	Iron	141-145	homeostatic iron regulator	Homo sapiens	79-82
16678024-9	2006	We hypothesize that the physiologic iron protective mechanisms are affected by the HFE mutations and should be investigated in all diseases characterized by the combination of iron overload and inflammation.	Iron	36-40	homeostatic iron regulator	Homo sapiens	83-86
16678024-9	2006	We hypothesize that the physiologic iron protective mechanisms are affected by the HFE mutations and should be investigated in all diseases characterized by the combination of iron overload and inflammation.	Iron	176-180	homeostatic iron regulator	Homo sapiens	83-86
16522632-1	2006	The high affinity iron uptake complex in the yeast plasma membrane (PM) consists of the ferroxidase, Fet3p, and the ferric iron permease, Ftr1p.	Iron	18-22	ferroxidase FET3	Saccharomyces cerevisiae S288C	101-106
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	122-126	ferroxidase FET3	Saccharomyces cerevisiae S288C	69-74
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	122-126	ferroxidase FET3	Saccharomyces cerevisiae S288C	132-137
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	151-155	ferroxidase FET3	Saccharomyces cerevisiae S288C	69-74
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	151-155	ferroxidase FET3	Saccharomyces cerevisiae S288C	132-137
16640576-0	2006	Iron depletion affects nitrogenase activity and expression of nifH and nifA genes in Herbaspirillum seropedicae.	Iron	0-4	nitrogenase iron protein	Herbaspirillum seropedicae	62-66
16640576-5	2006	Moreover, we provide evidence that expression of the nifH and nifA genes is iron dependent in a H. seropedicae genetic background.	Iron	76-80	nitrogenase iron protein	Herbaspirillum seropedicae	53-57
11938026-13	2002	When the cohort was divided according to gender, we found higher serum iron in females with than in those without HFE mutation (91 +/- 27 vs 73 +/- 25 microgram/dl;P=0.049), while a transferrin saturation index above 45% was observed in 36% of females with a mutation (vs 7% in wt/wt;P=0.06).	Iron	71-75	homeostatic iron regulator	Homo sapiens	114-117
11788568-1	2002	Recessively inherited mutations in the HFE gene are responsible for iron accumulation in most cases of hereditary haemochromatosis and may have a role in HCV infection.	Iron	68-72	homeostatic iron regulator	Homo sapiens	39-42
16597684-4	2006	Ceruloplasmin (Cp) is a copper-containing ferroxidase that functions as an antioxidant in part by oxidizing toxic ferrous iron to nontoxic ferric iron.	Iron	122-126	ceruloplasmin	Rattus norvegicus	0-13
11836162-3	2002	Since HFE gene mutations have recently been implicated in unbalanced iron homeostasis, we set out to examine the prevalence of these mutations in patients with hematologic disorders.	Iron	69-73	homeostatic iron regulator	Homo sapiens	6-9
16387364-3	2006	Fe(II) serves as substrate for Fe-uptake by being substrate for Fet3p; the resulting Fet3p-produced Fe(III) is then transported across the membrane via Ftr1p.	Iron	0-2	ferroxidase FET3	Saccharomyces cerevisiae S288C	64-69
11857056-2	2002	The HLA class I gene HFE seemingly no longer participates in immunity because it has lost its ability to bind peptides and it has acquired the ability to form complex with the receptor for iron-binding transferrin by regulating iron uptake by intestinal cells.	Iron	189-193	homeostatic iron regulator	Homo sapiens	21-24
11857056-2	2002	The HLA class I gene HFE seemingly no longer participates in immunity because it has lost its ability to bind peptides and it has acquired the ability to form complex with the receptor for iron-binding transferrin by regulating iron uptake by intestinal cells.	Iron	228-232	homeostatic iron regulator	Homo sapiens	21-24
16387364-3	2006	Fe(II) serves as substrate for Fe-uptake by being substrate for Fet3p; the resulting Fet3p-produced Fe(III) is then transported across the membrane via Ftr1p.	Iron	0-2	ferroxidase FET3	Saccharomyces cerevisiae S288C	85-90
16387364-4	2006	A model of metabolite channeling of this Fe(III) is tested here by first constructing and kinetically characterizing in Fe-uptake two Fet3p-Ftr1p chimeras in which the multicopper oxidase/ferroxidase domain of Fet3p has been fused to the Ftr1p iron permease.	Iron	41-43	ferroxidase FET3	Saccharomyces cerevisiae S288C	134-139
11935295-1	2002	The non-covalent association of beta 2-microglobulin with MHC class I molecules and MHC class I-type molecules such as FcRn or the hemochromatosis protein (HFE) is of major importance for their function, i.e., antigen presentation, IgG transport, and regulation of iron uptake, respectively.	Iron	265-269	homeostatic iron regulator	Homo sapiens	156-159
16387364-4	2006	A model of metabolite channeling of this Fe(III) is tested here by first constructing and kinetically characterizing in Fe-uptake two Fet3p-Ftr1p chimeras in which the multicopper oxidase/ferroxidase domain of Fet3p has been fused to the Ftr1p iron permease.	Iron	41-43	ferroxidase FET3	Saccharomyces cerevisiae S288C	210-215
16387364-6	2006	Specifically, Fe-uptake through the Fet3p, Ftr1p complex is insensitive to a potential Fe(III) trapping agent - citrate - whereas Fe-uptake via the chimeric proteins is competitively inhibited by this Fe(III) chelator.	Iron	14-16	ferroxidase FET3	Saccharomyces cerevisiae S288C	36-41
11903354-6	2002	Sequencing of the HFE gene also revealed two polymorphisms that had not previously been noted, -467 C--&gt;G and -970 T--&gt;G. Neither of these mutations appear to cause an abnormality in iron metabolism.	Iron	189-193	homeostatic iron regulator	Homo sapiens	18-21
16614410-3	2006	The copper requirement of the multicopper ferroxidases hephaestin and ceruloplasmin likely explains this link between copper and iron homeostasis in mammals.	Iron	129-133	hephaestin	Mus musculus	55-65
16362328-1	2006	The Arabidopsis FRO2 gene encodes the iron deficiency-inducible ferric chelate reductase responsible for reduction of iron at the root surface; subsequent transport of iron across the plasma membrane is carried out by a ferrous iron transporter (IRT1).	Iron	38-42	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
16362328-1	2006	The Arabidopsis FRO2 gene encodes the iron deficiency-inducible ferric chelate reductase responsible for reduction of iron at the root surface; subsequent transport of iron across the plasma membrane is carried out by a ferrous iron transporter (IRT1).	Iron	118-122	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
16362328-1	2006	The Arabidopsis FRO2 gene encodes the iron deficiency-inducible ferric chelate reductase responsible for reduction of iron at the root surface; subsequent transport of iron across the plasma membrane is carried out by a ferrous iron transporter (IRT1).	Iron	118-122	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
16362328-9	2006	While it is known that FRO2 is expressed at high levels in the outer layers of iron-deficient roots, histochemical staining of FRO3-GUS plants revealed that FRO3 is predominantly expressed in the vascular cylinder of roots.	Iron	79-83	ferric reduction oxidase 2	Arabidopsis thaliana	23-27
16606846-0	2006	Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase.	Iron	32-36	myo-inositol oxygenase	Homo sapiens	105-123
16718606-3	2006	Analysis of the crystal structure of NGAL expressed in E.coli showed that NGAL has the ability to bind catecholate type siderophores and in this way prevent bacteria from acquisition of siderophore-bound iron.	Iron	204-208	lipocalin 2	Mus musculus	37-41
16718606-3	2006	Analysis of the crystal structure of NGAL expressed in E.coli showed that NGAL has the ability to bind catecholate type siderophores and in this way prevent bacteria from acquisition of siderophore-bound iron.	Iron	204-208	lipocalin 2	Mus musculus	74-78
16718606-5	2006	This defect can be mimicked in wild-type mice by providing siderophore iron, which cannot be sequestered by NGAL, testifying to the specific role of NGAL as a siderophore binding protein in innate immunity.	Iron	71-75	lipocalin 2	Mus musculus	149-153
16615007-1	2006	Our objective was to assess the iron indexes of patients with one or more mutations of the HFE gene with a specific interest in studying the effect of the H63D/H63D genotype.	Iron	32-36	homeostatic iron regulator	Homo sapiens	91-94
16328268-1	2006	Iron regulatory proteins (IRP1 and IRP2) bind to iron response elements (IRE) on specific mRNAs, to affect the translation of many proteins involved in iron metabolism.	Iron	0-4	aconitase 1	Rattus norvegicus	26-30
16328268-1	2006	Iron regulatory proteins (IRP1 and IRP2) bind to iron response elements (IRE) on specific mRNAs, to affect the translation of many proteins involved in iron metabolism.	Iron	49-53	aconitase 1	Rattus norvegicus	26-30
16328268-1	2006	Iron regulatory proteins (IRP1 and IRP2) bind to iron response elements (IRE) on specific mRNAs, to affect the translation of many proteins involved in iron metabolism.	Iron	152-156	aconitase 1	Rattus norvegicus	26-30
16545682-8	2006	Both transferrin receptor 1 and activated IRP, indicators of iron depletion, increased in response to curcumin.	Iron	61-65	Wnt family member 2	Homo sapiens	42-45
16545687-5	2006	The objective was to show that iron overload in HFE-related hemochromatosis is associated with increased oxidative stress assessed through 8-iso-PGF(2alpha) urinary excretion, and that oxidative stress is impacted by iron-removal treatment (phlebotomy).	Iron	31-35	homeostatic iron regulator	Homo sapiens	48-51
16545687-5	2006	The objective was to show that iron overload in HFE-related hemochromatosis is associated with increased oxidative stress assessed through 8-iso-PGF(2alpha) urinary excretion, and that oxidative stress is impacted by iron-removal treatment (phlebotomy).	Iron	217-221	homeostatic iron regulator	Homo sapiens	48-51
16555178-5	2006	Iron is an inhibitory co-factor of URO-D activity in hepatocytes.	Iron	0-4	uroporphyrinogen decarboxylase	Homo sapiens	35-40
16555178-6	2006	Accordingly, in support of the critical role of iron, the clinical efficacy of iron removal is coupled to an improvement of hepatic URO-D activities.	Iron	48-52	uroporphyrinogen decarboxylase	Homo sapiens	132-137
16555178-6	2006	Accordingly, in support of the critical role of iron, the clinical efficacy of iron removal is coupled to an improvement of hepatic URO-D activities.	Iron	79-83	uroporphyrinogen decarboxylase	Homo sapiens	132-137
16418170-3	2006	Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age.	Iron	45-49	transferrin receptor	Mus musculus	76-80
16418170-3	2006	Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age.	Iron	45-49	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	94-101
16418170-3	2006	Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age.	Iron	149-153	transferrin receptor	Mus musculus	76-80
16418170-3	2006	Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age.	Iron	149-153	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	94-101
16802538-8	2006	CONCLUSION: The present study indicates that it is worth screening patients with IDCM for iron parameters given the increased prevalence of disease-predisposing HFE constellations.	Iron	90-94	homeostatic iron regulator	Homo sapiens	161-164
16533407-8	2006	CONCLUSION: We conclude that the iron-related phenotypes of hemochromatosis probands with HFE C282Y homozygosity are similar in those with and without Native American ancestry reports.	Iron	33-37	homeostatic iron regulator	Homo sapiens	90-93
16509583-7	2006	A related docking study of 13e in the 15-LOX binding site indicates that the C-3 p-SO2Me COX-2 pharmacophore was positioned in a region closer to the catalytic iron site where it undergoes a hydrogen bonding interaction with His541 and His366, and that the C-1 p-i-Pr substituent is buried deep in a hydrophobic pocket (Ile414, Ile418, Met419 and Ile593) near the base of the 15-LOX binding site.	Iron	160-164	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	89-94
16511496-0	2006	Mitoferrin is essential for erythroid iron assimilation.	Iron	38-42	solute carrier family 25 member 37	Danio rerio	0-10
16511496-4	2006	Here we describe a zebrafish mutant, frascati (frs), that shows profound hypochromic anaemia and erythroid maturation arrest owing to defects in mitochondrial iron uptake.	Iron	159-163	solute carrier family 25 member 37	Danio rerio	37-45
16511496-4	2006	Here we describe a zebrafish mutant, frascati (frs), that shows profound hypochromic anaemia and erythroid maturation arrest owing to defects in mitochondrial iron uptake.	Iron	159-163	solute carrier family 25 member 37	Danio rerio	47-50
16511496-8	2006	Disruption of the yeast mfrn orthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis.	Iron	75-79	solute carrier family 25 member 37	Danio rerio	24-28
11804665-0	2002	Serum ceruloplasmin and ferroxidase activity are decreased in HFE C282Y homozygote male iron-overloaded patients.	Iron	88-92	homeostatic iron regulator	Homo sapiens	62-65
16511496-8	2006	Disruption of the yeast mfrn orthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis.	Iron	109-113	solute carrier family 25 member 37	Danio rerio	24-28
16511496-10	2006	Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts.	Iron	65-69	solute carrier family 25 member 37	Danio rerio	19-23
16480904-1	2006	Iron regulatory proteins 1 and 2 (IRPs) are homologous mammalian cytosolic proteins that sense intracellular iron levels and post-transcriptionally regulate expression of ferritin, transferrin receptor, and other iron metabolism proteins.	Iron	109-113	aconitase 1	Homo sapiens	0-32
15455041-0	2002	Aedes aegypti ferritin heavy chain homologue: feeding of iron or blood influences message levels, lengths and subunit abundance.	Iron	57-61	Ferritin 1 heavy chain homologue	Drosophila melanogaster	14-22
15455041-2	2002	Here we report the developmental and organ specific pattern of expression of the ferritin HCH messages and of both subunit types in control sugar-fed mosquitoes, in those exposed to high levels of dietary iron, and after blood feeding.	Iron	205-209	Ferritin 1 heavy chain homologue	Drosophila melanogaster	81-89
16480904-1	2006	Iron regulatory proteins 1 and 2 (IRPs) are homologous mammalian cytosolic proteins that sense intracellular iron levels and post-transcriptionally regulate expression of ferritin, transferrin receptor, and other iron metabolism proteins.	Iron	213-217	aconitase 1	Homo sapiens	0-32
16510596-2	2006	One mechanism of iron uptake is mediated by the cell surface transferrin receptor (TfR).	Iron	17-21	transferrin receptor	Homo sapiens	61-81
11781385-1	2002	Nramp2 is a widely expressed metal-ion transporter that is involved in dietary iron absorption in the duodenum and iron uptake from transferrin in peripheral tissues.	Iron	79-83	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-6
11781385-1	2002	Nramp2 is a widely expressed metal-ion transporter that is involved in dietary iron absorption in the duodenum and iron uptake from transferrin in peripheral tissues.	Iron	115-119	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-6
16510596-2	2006	One mechanism of iron uptake is mediated by the cell surface transferrin receptor (TfR).	Iron	17-21	transferrin receptor	Homo sapiens	83-86
16222708-0	2006	A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes.	Iron	103-107	mitogen-activated protein kinase 14	Mus musculus	54-57
11781385-3	2002	Nramp2 has at least two alternatively spliced isoforms, one of which contains an iron-responsive element in its 3"-untranslated region.	Iron	81-85	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-6
11781385-6	2002	cDNA microarray analysis revealed that Nramp2 regulation is controlled discordantly from other iron-regulated genes and classical macrophage-activation genes in different mouse strains.	Iron	95-99	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	39-45
11781385-7	2002	We suggest that Nramp2 is regulated independently of known iron-responsive genes in macrophages, and its function in host defense is unrelated to Nramp1.	Iron	59-63	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	16-22
16222708-0	2006	A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes.	Iron	103-107	lipocalin 2	Mus musculus	97-102
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	41-45	Fit1p	Saccharomyces cerevisiae S288C	0-4
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	41-45	Fit2p	Saccharomyces cerevisiae S288C	6-10
16222708-1	2006	SIP24 is an acute phase iron binding lipocalin physiologically expressed in vivo in developing cartilage by prehypertrophic/hypertrophic chondrocytes.	Iron	24-28	lipocalin 2	Mus musculus	0-5
16754360-1	2006	The ATP binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs crucial roles in both the biogenesis of cytosolic/nuclear iron-sulfur proteins and cellular iron homeostasis.	Iron	152-156	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	43-48
11739192-1	2001	Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues.	Iron	73-77	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-28
11739192-1	2001	Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues.	Iron	73-77	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	30-34
11739192-1	2001	Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues.	Iron	158-162	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-28
11739192-1	2001	Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues.	Iron	158-162	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	30-34
11739192-2	2001	Iron transport and expression of the 2 isoforms of DMT1 was studied in erythroid cells that consume large quantities of iron for biosynthesis of hemoglobin.	Iron	120-124	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	51-55
11739192-3	2001	In mk/mk mice that express a loss-of-function mutant variant of DMT1, reticulocytes have a decreased cellular iron uptake and iron incorporation into heme.	Iron	110-114	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	64-68
11739192-3	2001	In mk/mk mice that express a loss-of-function mutant variant of DMT1, reticulocytes have a decreased cellular iron uptake and iron incorporation into heme.	Iron	126-130	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	64-68
16754360-2	2006	Since the function of the mitochondrial iron-sulfur cluster (ISC) assembly machinery is also required for these two processes, Atm1p is thought to translocate a still unknown product of this pathway to the cytosol.	Iron	40-44	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	127-132
11739192-7	2001	Experiments with isoform-specific anti-DMT1 antiserum strongly suggest that it is the non-iron-response element containing isoform II of DMT1 that is predominantly expressed by the erythroid cells.	Iron	90-94	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	39-43
11739192-7	2001	Experiments with isoform-specific anti-DMT1 antiserum strongly suggest that it is the non-iron-response element containing isoform II of DMT1 that is predominantly expressed by the erythroid cells.	Iron	90-94	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	137-141
16267047-9	2006	Iron uptake assays demonstrated that SmDMT1s were able to rescue yeast growth in ferrous iron-transport deficient yeast (fet3fet4).	Iron	0-4	ferroxidase FET3	Saccharomyces cerevisiae S288C	121-129
11739192-9	2001	Together, these results provide further evidence that DMT1 plays a central role in iron acquisition via the transferrin cycle in erythroid cells.	Iron	83-87	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	54-58
12036461-2	2001	The HFE gene mutation is associated with elevated iron uptake and serum iron overloading.	Iron	50-54	homeostatic iron regulator	Homo sapiens	4-7
16267047-9	2006	Iron uptake assays demonstrated that SmDMT1s were able to rescue yeast growth in ferrous iron-transport deficient yeast (fet3fet4).	Iron	89-93	ferroxidase FET3	Saccharomyces cerevisiae S288C	121-129
12036461-2	2001	The HFE gene mutation is associated with elevated iron uptake and serum iron overloading.	Iron	72-76	homeostatic iron regulator	Homo sapiens	4-7
16341089-6	2006	It forms a complex with the cysteine desulfurase Nfs1 and is required for formation of an Fe/S cluster on the Isu scaffold proteins.	Iron	90-92	NFS1 cysteine desulfurase	Homo sapiens	49-53
11737244-1	2001	BACKGROUND: Oxidative stress and mitochondrial dysfunction have long been considered to play a role in Friedreich"s ataxia, a neurodegenerative disease due to a GAA expansion in a gene coding for a mitochondrial protein (frataxin), implicated in the regulation of iron metabolism.	Iron	264-268	frataxin	Homo sapiens	221-229
16671455-2	2006	Ceruloplasmin is involved in iron metabolism by oxidizing ferrous iron to ferric iron.	Iron	29-33	ceruloplasmin	Rattus norvegicus	0-13
21207699-0	2001	[The expression of p97 on the membrane of the reticulocyte and the role in iron uptake in rabbit].	Iron	75-79	melanotransferrin	Oryctolagus cuniculus	19-22
21207699-8	2001	Reticulocytes, depleted endogenous-transferrin and then treated by PI-PLC, gave a significant decrease in iron uptake in cytosol and in heme (P &lt; 0.05).	Iron	106-110	serotransferrin	Oryctolagus cuniculus	35-46
21207699-9	2001	CONCLUSION: The results support the possibility that p97 might be able to be expressed on the membrane of reticulocytes and plays a role in non-transferrin bound iron uptake by this type of cells in rabbit.	Iron	162-166	melanotransferrin	Oryctolagus cuniculus	53-56
16671455-2	2006	Ceruloplasmin is involved in iron metabolism by oxidizing ferrous iron to ferric iron.	Iron	58-70	ceruloplasmin	Rattus norvegicus	0-13
16671455-3	2006	The present study examines whether thrombin modulates brain ceruloplasmin levels and whether exogenous ceruloplasmin reduces brain edema induced by ferrous iron in vivo.	Iron	156-160	ceruloplasmin	Rattus norvegicus	103-116
16671455-11	2006	Co-injection of ferrous iron with ceruloplasmin reduced ferrous iron-induced brain edema (p &lt; 0.05).	Iron	16-28	ceruloplasmin	Rattus norvegicus	34-47
16671455-11	2006	Co-injection of ferrous iron with ceruloplasmin reduced ferrous iron-induced brain edema (p &lt; 0.05).	Iron	56-68	ceruloplasmin	Rattus norvegicus	34-47
16671455-12	2006	Our results demonstrate that thrombin increases brain ceruloplasmin levels and exogenous ceruloplasmin reduces ferrous iron-induced brain edema, suggesting that ceruloplasmin up-regulation may contribute to thrombin-induced brain tolerance to ICH by limiting the injury caused by ferrous iron released from the hematoma.	Iron	111-123	ceruloplasmin	Rattus norvegicus	89-102
16671455-12	2006	Our results demonstrate that thrombin increases brain ceruloplasmin levels and exogenous ceruloplasmin reduces ferrous iron-induced brain edema, suggesting that ceruloplasmin up-regulation may contribute to thrombin-induced brain tolerance to ICH by limiting the injury caused by ferrous iron released from the hematoma.	Iron	111-123	ceruloplasmin	Rattus norvegicus	89-102
11606717-8	2001	The megalin-dependent, cubilin-mediated endocytosis of Tf and the potential of the receptors thereby to facilitate iron uptake were further confirmed by analyzing the uptake of (125)I- and (59)Fe-labeled Tf in cultured yolk sac cells.	Iron	115-119	cubilin	Canis lupus familiaris	23-30
11606717-8	2001	The megalin-dependent, cubilin-mediated endocytosis of Tf and the potential of the receptors thereby to facilitate iron uptake were further confirmed by analyzing the uptake of (125)I- and (59)Fe-labeled Tf in cultured yolk sac cells.	Iron	193-195	cubilin	Canis lupus familiaris	23-30
16360114-5	2006	The purified P450 was in the low-spin iron state, and the spin equilibrium was not perturbed by any of the potential substrates vitamin D(3), 1alpha- or 25-hydroxy vitamin D(3), or cholesterol.	Iron	38-42	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	13-17
11800564-1	2001	The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	63-67	transferrin receptor	Homo sapiens	4-24
11800564-1	2001	The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	63-67	transferrin receptor	Homo sapiens	26-29
11800564-1	2001	The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	63-67	homeostatic iron regulator	Homo sapiens	101-104
16546437-0	2006	Heat shock protein 27 downregulates the transferrin receptor 1-mediated iron uptake.	Iron	72-76	transferrin receptor	Homo sapiens	40-62
11557513-7	2001	The high sequence conservation between rat and mouse hephaestin is consistent with this protein playing a central role in intestinal iron absorption, although its precise function remains to be determined.	Iron	133-137	hephaestin	Mus musculus	53-63
16546437-5	2006	In this study, the regulation of transferrin receptor 1 (TfR1)-mediated iron uptake by human hsp27 was investigated in CCL39 cells by overexpression of human hsp27 and its dominant-negative mutant (hsp27-3G).	Iron	72-76	transferrin receptor	Homo sapiens	33-55
11601557-3	2001	Hereditary hemochromatosis should be considered in the differential diagnosis when a patient presents with cardiomyopathy and genetic testing for HFE gene variants influencing iron overload is now available as a clinical adjunct for diagnosis and patient management issues.	Iron	176-180	homeostatic iron regulator	Homo sapiens	146-149
16546437-5	2006	In this study, the regulation of transferrin receptor 1 (TfR1)-mediated iron uptake by human hsp27 was investigated in CCL39 cells by overexpression of human hsp27 and its dominant-negative mutant (hsp27-3G).	Iron	72-76	transferrin receptor	Homo sapiens	57-61
11673399-2	2001	Identification of HFE, the gene most commonly mutated in patients with hereditary hemochromatosis, has allowed molecular diagnosis and paved the way for identification of other genes, such as TFR2, that are important in non-HFE-associated iron overload.	Iron	239-243	homeostatic iron regulator	Homo sapiens	18-21
16546437-6	2006	The results showed that overexpression of hsp27 diminished intracellular labile iron pool, increased the binding activity of iron regulatory protein (IRP) to iron responsive element (IRE) and the cell surface-expressed TfR1s.	Iron	125-129	Wnt family member 2	Homo sapiens	150-153
16546437-7	2006	However, the increased surface-expressed TfR1s resulted in decrease rather than increase of iron uptake.	Iron	92-96	transferrin receptor	Homo sapiens	41-45
16546437-14	2006	Our findings indicate that hsp27 down-regulates TfR1-mediated iron uptake via stabilization of the cortical actin cytoskeleton rather than the classical IRP/IRE mode.	Iron	62-66	transferrin receptor	Homo sapiens	48-52
16755844-8	2006	BNP was weakly related to myocardial iron (Rs = -0.35, p &lt; 0.001) and was abnormal in only 5 patients.	Iron	37-41	natriuretic peptide B	Homo sapiens	0-3
16386215-0	2006	[HFE, a MHC class Ib molecule that regulates iron metabolism].	Iron	45-49	homeostatic iron regulator	Homo sapiens	1-4
16140386-3	2006	Furthermore, our study examined the effect of Fe status on astrocytic transferrin receptor (TfR) and divalent metal transporter (DMT-1) levels and their relationship to Mn uptake, as both have been implicated as putative Mn transporters.	Iron	46-48	transferrin receptor	Rattus norvegicus	92-95
16140386-8	2006	TfR levels were significantly increased (p&lt;0.05) due to ID and decreased in astrocytes exposed to +Fe treatments.	Iron	102-104	transferrin receptor	Rattus norvegicus	0-3
16819431-1	2006	The iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	4-8	aconitase 1	Homo sapiens	30-34
16819431-1	2006	The iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	99-103	aconitase 1	Homo sapiens	30-34
16819431-4	2006	The converse regulation of ferritin and TfR synthesis, resulting from lack of binding of IRPs to IRE, occurs in cells with high iron level.	Iron	128-132	transferrin receptor	Homo sapiens	40-43
16598939-10	2006	The lower the iron stores, the stronger the influence of ferritin on TfR.	Iron	14-18	transferrin receptor	Homo sapiens	69-72
16598939-11	2006	The TfR concentrations are higher in children than adults respongsing to physiologically low iron stores in children.	Iron	93-97	transferrin receptor	Homo sapiens	4-7
16095817-7	2005	Finally, the production of reactive oxygen species (ROS) was inhibited by 30% by iron chelators desferrioxamine (DFO) and BIP in ScN 2 a cells, whereas no significant effect of iron chelators on basal ROS production was observed in N2a cells.	Iron	81-85	sodium channel, voltage-gated, type II, alpha	Mus musculus	129-136
16095817-8	2005	This study indicates that cellular resistance to oxidative stress in ScN 2 a cells is associated with intracellular status of reactive iron.	Iron	135-139	sodium channel, voltage-gated, type II, alpha	Mus musculus	69-76
16273299-0	2005	HFE gene mutations in Polish patients with disturbances of iron metabolism: an initial assessment.	Iron	59-63	homeostatic iron regulator	Homo sapiens	0-3
16273299-4	2005	The HFE gene mutations were confirmed in 24 of 41 (59%) cases with symptoms of chronic liver disease and iron overload, significantly more frequently in HCV-negative patients (12/14 vs. 12/27; chi2=8.28; p=0.05).	Iron	105-109	homeostatic iron regulator	Homo sapiens	4-7
16273299-8	2005	HCV infection seems to be a negative predictive marker of HFE gene mutations in patients with iron overload.	Iron	94-98	homeostatic iron regulator	Homo sapiens	58-61
16343946-3	2005	Thus, in vertebrates iron is transported through the circulation bound to transferrin (Tf) and delivered to cells through an endocytotic cycle involving the transferrin receptor (TfR).	Iron	21-25	transferrin receptor	Homo sapiens	157-177
16343946-3	2005	Thus, in vertebrates iron is transported through the circulation bound to transferrin (Tf) and delivered to cells through an endocytotic cycle involving the transferrin receptor (TfR).	Iron	21-25	transferrin receptor	Homo sapiens	179-182
16343946-4	2005	We have previously presented a model for the Tf-TfR complex in its iron-bearing form, the diferric transferrin (dTf)-TfR complex [Cheng, Y., Zak, O., Aisen, P., Harrison, S.C., Walz, T., 2004.	Iron	67-71	transferrin receptor	Homo sapiens	48-51
16343946-4	2005	We have previously presented a model for the Tf-TfR complex in its iron-bearing form, the diferric transferrin (dTf)-TfR complex [Cheng, Y., Zak, O., Aisen, P., Harrison, S.C., Walz, T., 2004.	Iron	67-71	transferrin receptor	Homo sapiens	117-120
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	114-118	transferrin receptor	Rattus norvegicus	40-60
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	114-118	transferrin receptor	Rattus norvegicus	62-65
16324464-14	2005	Iron parameters can be influenced by age, sex, HFE genotype, blood donation, alcohol intake and hepatitis C virus infection.	Iron	0-4	homeostatic iron regulator	Homo sapiens	47-50
16684489-2	2005	It is a autosomal recessive neurodegenerative disease, caused by a mutation in the FRDA gene, which originates decreased expression of frataxin, a mitochondrial protein involved in iron metabolism.	Iron	181-185	frataxin	Homo sapiens	83-87
16684489-2	2005	It is a autosomal recessive neurodegenerative disease, caused by a mutation in the FRDA gene, which originates decreased expression of frataxin, a mitochondrial protein involved in iron metabolism.	Iron	181-185	frataxin	Homo sapiens	135-143
16344607-6	2005	By immuno-histochemical study of biopsied liver samples, the expression of transferrin receptor 1 (TfR1), which mediates cellular iron uptake by serum transferrin was increased.	Iron	130-134	transferrin receptor	Homo sapiens	75-97
16344607-6	2005	By immuno-histochemical study of biopsied liver samples, the expression of transferrin receptor 1 (TfR1), which mediates cellular iron uptake by serum transferrin was increased.	Iron	130-134	transferrin receptor	Homo sapiens	99-103
16344607-8	2005	Fe-labeled transferrin incorporation (but not transferrin non-bound iron (NTBI)) into the cells is also increased, suggesting that the increased TfR1 is functional.	Iron	0-2	transferrin receptor	Homo sapiens	145-149
16137900-6	2005	In our cohort of beta-thalassemic patients, CCL18/PARC showed a significant negative correlation to iron chelation therapy and a significant positive correlation to ferritin and chitotriosidase levels, the latter only in the patients with the wild type genotype for the enzyme.	Iron	100-104	C-C motif chemokine ligand 18	Homo sapiens	44-49
16137900-6	2005	In our cohort of beta-thalassemic patients, CCL18/PARC showed a significant negative correlation to iron chelation therapy and a significant positive correlation to ferritin and chitotriosidase levels, the latter only in the patients with the wild type genotype for the enzyme.	Iron	100-104	C-C motif chemokine ligand 18	Homo sapiens	50-54
16137900-7	2005	Our study demonstrates that beta-thalassemic patients have increased CCL18/PARC levels that could be of value in monitoring iron overload and compliance to therapy.	Iron	124-128	C-C motif chemokine ligand 18	Homo sapiens	69-74
16137900-7	2005	Our study demonstrates that beta-thalassemic patients have increased CCL18/PARC levels that could be of value in monitoring iron overload and compliance to therapy.	Iron	124-128	C-C motif chemokine ligand 18	Homo sapiens	75-79
16140024-1	2005	Hereditary hemochromatosis (HH) is a genetic iron overload disease, in the majority of cases associated with homozygosity for the C282Y mutation of the HFE gene.	Iron	45-49	homeostatic iron regulator	Homo sapiens	152-155
16140024-9	2005	All HFE C282Y carriers presented significantly lower serum transferrin levels than the wild type group, a difference that could not be explained solely by the degree of iron overload.	Iron	169-173	homeostatic iron regulator	Homo sapiens	4-7
16308480-5	2005	While total RNA yield and abundance were not significantly altered, both iron and aluminum were found to induce HSP27, COX-2, betaAPP and DAXX gene expression.	Iron	73-77	death domain associated protein	Homo sapiens	138-142
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
16271884-2	2005	Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less iron is released from Fe-Tf inside cells expressing W641A/F760A-TfR than cells expressing wild-type TfR (wtTfR).	Iron	218-222	transferrin receptor	Homo sapiens	138-141
16271884-3	2005	Electron paramagnetic resonance spectroscopy shows that binding at acidic pH to wtTfR, but not W641A/F760A-TfR, changes the Tf iron binding site &gt; or =30 A from the TfR W641/F760 patch.	Iron	127-131	transferrin receptor	Homo sapiens	82-85
16271884-4	2005	Mutation of Tf histidine residues predicted to interact with the W641/F760 patch eliminates TfR-dependent acceleration of iron release.	Iron	122-126	transferrin receptor	Homo sapiens	92-95
16271884-5	2005	Identification of TfR and Tf residues critical for TfR-facilitated iron release, yet distant from a Tf iron binding site, demonstrates that TfR transmits long-range conformational changes and stabilizes the conformation of apo-Tf to accelerate iron release from Fe-Tf.	Iron	67-71	transferrin receptor	Homo sapiens	18-21
11535534-5	2001	In MEL cells, expression of TfR1 was induced by desferrioxamine, an iron chelator, and it was reduced by ferric nitrate.	Iron	68-72	transferrin receptor	Mus musculus	28-32
16271884-5	2005	Identification of TfR and Tf residues critical for TfR-facilitated iron release, yet distant from a Tf iron binding site, demonstrates that TfR transmits long-range conformational changes and stabilizes the conformation of apo-Tf to accelerate iron release from Fe-Tf.	Iron	67-71	transferrin receptor	Homo sapiens	51-54
16271884-5	2005	Identification of TfR and Tf residues critical for TfR-facilitated iron release, yet distant from a Tf iron binding site, demonstrates that TfR transmits long-range conformational changes and stabilizes the conformation of apo-Tf to accelerate iron release from Fe-Tf.	Iron	67-71	transferrin receptor	Homo sapiens	51-54
16271884-5	2005	Identification of TfR and Tf residues critical for TfR-facilitated iron release, yet distant from a Tf iron binding site, demonstrates that TfR transmits long-range conformational changes and stabilizes the conformation of apo-Tf to accelerate iron release from Fe-Tf.	Iron	103-107	transferrin receptor	Homo sapiens	51-54
11590123-1	2001	Friedreich"s ataxia (FRDA) results from a generalized deficiency of mitochondrial iron-sulfur protein activity ascribed to mitochondrial iron overload.	Iron	82-86	frataxin	Homo sapiens	21-25
16271884-5	2005	Identification of TfR and Tf residues critical for TfR-facilitated iron release, yet distant from a Tf iron binding site, demonstrates that TfR transmits long-range conformational changes and stabilizes the conformation of apo-Tf to accelerate iron release from Fe-Tf.	Iron	103-107	transferrin receptor	Homo sapiens	51-54
11590127-2	2001	Several lines of evidence have suggested that frataxin is involved in mitochondrial iron homeostasis.	Iron	84-88	frataxin	Homo sapiens	46-54
11590127-6	2001	The rescue of the low MMP, and high mitochondrial iron concentration by frataxin overexpression suggests that these cellular phenotypes are relevant to the central pathophysiological process in FRDA which is aggravated by exposure to free iron.	Iron	50-54	frataxin	Homo sapiens	72-80
11590127-6	2001	The rescue of the low MMP, and high mitochondrial iron concentration by frataxin overexpression suggests that these cellular phenotypes are relevant to the central pathophysiological process in FRDA which is aggravated by exposure to free iron.	Iron	239-243	frataxin	Homo sapiens	72-80
11590127-6	2001	The rescue of the low MMP, and high mitochondrial iron concentration by frataxin overexpression suggests that these cellular phenotypes are relevant to the central pathophysiological process in FRDA which is aggravated by exposure to free iron.	Iron	239-243	frataxin	Homo sapiens	194-198
16271884-5	2005	Identification of TfR and Tf residues critical for TfR-facilitated iron release, yet distant from a Tf iron binding site, demonstrates that TfR transmits long-range conformational changes and stabilizes the conformation of apo-Tf to accelerate iron release from Fe-Tf.	Iron	103-107	transferrin receptor	Homo sapiens	51-54
16271884-5	2005	Identification of TfR and Tf residues critical for TfR-facilitated iron release, yet distant from a Tf iron binding site, demonstrates that TfR transmits long-range conformational changes and stabilizes the conformation of apo-Tf to accelerate iron release from Fe-Tf.	Iron	103-107	transferrin receptor	Homo sapiens	51-54
11555280-2	2001	After overcoming terminological complications to sort out microbial nifS from sufS genes, we connect a bacterial operon, recently found to be involved in iron metabolism, the formation of [Fe-S] clusters and oxidative stress to a potentially important gene (sufB) carried on the degenerate plastid genome of malaria and related parasites.	Iron	154-158	NFS1 cysteine desulfurase	Homo sapiens	68-72
16315132-1	2005	The term hemochromatosis is commonly used as synonymous with HFE-associated genetic iron overload but several rarer causes of an identical clinicopathological syndrome have been described in recent years.	Iron	84-88	homeostatic iron regulator	Homo sapiens	61-64
11555280-2	2001	After overcoming terminological complications to sort out microbial nifS from sufS genes, we connect a bacterial operon, recently found to be involved in iron metabolism, the formation of [Fe-S] clusters and oxidative stress to a potentially important gene (sufB) carried on the degenerate plastid genome of malaria and related parasites.	Iron	189-193	NFS1 cysteine desulfurase	Homo sapiens	68-72
16315134-1	2005	Type 1 hereditary hemochromatosis is a common disorder of iron overload occurring in individuals homozygous for the C282Y HFE gene mutation.	Iron	58-62	homeostatic iron regulator	Homo sapiens	122-125
16315138-7	2005	Non-HFE HC gene products, while responsible for rarer cases of HC as compared with HFE, are much more central than HFE in human iron homeostasis and understanding their function will greatly advance our comprehension of iron trafficking in health and disease.	Iron	128-132	homeostatic iron regulator	Homo sapiens	4-7
16315138-7	2005	Non-HFE HC gene products, while responsible for rarer cases of HC as compared with HFE, are much more central than HFE in human iron homeostasis and understanding their function will greatly advance our comprehension of iron trafficking in health and disease.	Iron	220-224	homeostatic iron regulator	Homo sapiens	4-7
11722599-8	2001	These results suggest that a lower peripheral blood lymphocyte count is associated with a greater degree of iron loading in HFE haemochromatosis but not in African iron overload, and they support the notion that the lymphocyte count may serve as a marker of a non-HFE gene that influences the clinical expression of HFE haemochromatosis.	Iron	108-112	homeostatic iron regulator	Homo sapiens	124-127
16315138-7	2005	Non-HFE HC gene products, while responsible for rarer cases of HC as compared with HFE, are much more central than HFE in human iron homeostasis and understanding their function will greatly advance our comprehension of iron trafficking in health and disease.	Iron	220-224	homeostatic iron regulator	Homo sapiens	83-86
16315138-7	2005	Non-HFE HC gene products, while responsible for rarer cases of HC as compared with HFE, are much more central than HFE in human iron homeostasis and understanding their function will greatly advance our comprehension of iron trafficking in health and disease.	Iron	220-224	homeostatic iron regulator	Homo sapiens	83-86
16254261-1	2005	This study investigated the efficiency of serum soluble transferrin receptor (sTfR) for assessing body iron status at different stages of iron deficiency.	Iron	103-107	transferrin receptor	Homo sapiens	56-76
11481035-3	2001	Iron X-ray absorption spectroscopy (XAS) has been used to examine the structure of the ferriheme site in the N(omega)-hydroxy-L-arginine-bound full-length neuronal NOS in the presence of (6R)-5,6,7,8-tetrahydro-L-biopterin.	Iron	0-4	nitric oxide synthase 1	Homo sapiens	155-167
16178952-3	2005	The HFE gene encodes for a protein that modulates iron absorption.	Iron	50-54	homeostatic iron regulator	Homo sapiens	4-7
11509115-3	2001	Incidences of spontaneous liver tumors in LEC, WKAH.C-Atp7b and WKAH rats correlated with hepatic copper and iron concentrations.	Iron	109-113	ATPase copper transporting beta	Rattus norvegicus	54-59
16187760-1	2005	We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions.	Iron	271-275	H2A.X variant histone	Homo sapiens	108-112
11472242-3	2001	TPH belongs to the family of the aromatic amino acid hydroxylases, including phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH), which all have a strict requirement for dioxygen, non-heme iron (II) and tetrahydrobiopterin (BH4).	Iron	199-203	phenylalanine hydroxylase	Homo sapiens	77-102
11472242-3	2001	TPH belongs to the family of the aromatic amino acid hydroxylases, including phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH), which all have a strict requirement for dioxygen, non-heme iron (II) and tetrahydrobiopterin (BH4).	Iron	199-203	phenylalanine hydroxylase	Homo sapiens	104-107
16187760-1	2005	We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions.	Iron	271-275	H2A.X variant histone	Homo sapiens	114-124
11458969-3	2001	RESULTS: Most cases of hereditary hemochromatosis are caused by a single mutation to the HFE gene, resulting in unregulated dietary iron uptake.	Iron	132-136	homeostatic iron regulator	Homo sapiens	89-92
15914561-2	2005	Patients with HH and Hfe-deficient (Hfe-/-) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in response to iron loading.	Iron	90-94	homeostatic iron regulator	Homo sapiens	21-24
11301319-0	2001	The effect of substrate, dihydrobiopterin, and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase.	Iron	136-140	phenylalanine hydroxylase	Homo sapiens	162-187
11301319-1	2001	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin (BH(4)) and non-heme iron-dependent enzyme that hydroxylates L-Phe to L-Tyr.	Iron	78-82	phenylalanine hydroxylase	Homo sapiens	0-25
11301319-1	2001	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin (BH(4)) and non-heme iron-dependent enzyme that hydroxylates L-Phe to L-Tyr.	Iron	78-82	phenylalanine hydroxylase	Homo sapiens	27-30
15914561-2	2005	Patients with HH and Hfe-deficient (Hfe-/-) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in response to iron loading.	Iron	181-185	homeostatic iron regulator	Homo sapiens	21-24
16138214-5	2005	The analysis of the effects of HFE mutations on iron metabolism and anemia with biochemical parameters was possible in 118 patients of this study (hemoglobin, hematocrit, ferritin levels, transferrin saturation, and serum iron).	Iron	48-52	homeostatic iron regulator	Homo sapiens	31-34
11396936-4	2001	The freshly regenerated sodium form of Chelex-100 also removes the iron atom from native soybean lipoxygenase 3, but only in sodium bicarbonate buffer at pH 8.0.	Iron	67-71	seed linoleate 9S-lipoxygenase-3	Glycine max	97-111
16099205-0	2005	Intron 2 [IVS2, T-C +4] HFE gene mutation associated with S65C causes alternative RNA splicing and is responsible for iron overload.	Iron	118-122	homeostatic iron regulator	Homo sapiens	24-27
11378262-1	2001	OBJECTIVE: Serum levels of the soluble transferrin receptor (sTfR) vary depending on the erythropoietic activity and iron status.	Iron	117-121	transferrin receptor	Rattus norvegicus	39-59
16099205-6	2005	CONCLUSION: : The existence in our proband of a partly-altered HFE protein in the region encoded by exon 2 might be responsible for the histologically-demonstrated iron overload.	Iron	164-168	homeostatic iron regulator	Homo sapiens	63-66
16165397-2	2005	Detection of soluble transferrin receptor (sTfR) allows for quantitative evaluation of intracellular iron stores, especially under circumstances of chronic inflammatory state, as CHC.	Iron	101-105	transferrin receptor	Homo sapiens	21-41
11358905-3	2001	Concurrently, an increasing number of genes have been shown to interact with HFE in iron metabolism.	Iron	84-88	homeostatic iron regulator	Homo sapiens	77-80
16155407-0	2005	Iron chelator induces MIP-alpha/CCL20 in human intestinal epithelial cells: implication for triggering mucosal adaptive immunity.	Iron	0-4	C-C motif chemokine ligand 20	Homo sapiens	32-37
11278657-0	2001	The hairpin loop but not the bulged C of the iron responsive element is essential for high affinity binding to iron regulatory protein-1.	Iron	45-49	aconitase 1	Homo sapiens	111-136
11320302-2	2001	Other genes regulated by DtxR include those that encode proteins involved in siderophore-mediated iron uptake.	Iron	98-102	MarR family transcriptional regulator	Corynebacterium diphtheriae	25-29
16155407-2	2005	Microarray-based gene expression profiling revealed that iron chelator also induces macrophage inflammatory protein 3 alpha (MIP-3alpha)/CC chemokine-ligand 20 (CCL20).	Iron	57-61	C-C motif chemokine ligand 20	Homo sapiens	84-123
16155407-2	2005	Microarray-based gene expression profiling revealed that iron chelator also induces macrophage inflammatory protein 3 alpha (MIP-3alpha)/CC chemokine-ligand 20 (CCL20).	Iron	57-61	C-C motif chemokine ligand 20	Homo sapiens	125-135
16155407-2	2005	Microarray-based gene expression profiling revealed that iron chelator also induces macrophage inflammatory protein 3 alpha (MIP-3alpha)/CC chemokine-ligand 20 (CCL20).	Iron	57-61	C-C motif chemokine ligand 20	Homo sapiens	161-166
11497259-14	2001	The synergistic effects on inhibition of DNA synthesis between TfR-ODna and DFO or hydroxyurea suggest that inhibition of breast cancer cell growth by TfR-ODna is produced by depletion of iron pools that are required for DNA synthesis in tumor cells.	Iron	188-192	transferrin receptor	Homo sapiens	151-154
16155407-3	2005	As CCL20 is chemotactic for the cells involved in host adaptive immunity, this suggests that iron chelator may stimulate IECs to have the capacity to link mucosal innate and adaptive immunity.	Iron	93-97	C-C motif chemokine ligand 20	Homo sapiens	3-8
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	76-80	transferrin receptor	Homo sapiens	0-20
11351132-3	2001	Loss of the homologue of frataxin in yeast is associated with mitochondrial iron overload, increased sensitivity to oxidative stress and profound deficit of oxidative phosphorylation.	Iron	76-80	frataxin	Homo sapiens	25-33
11351132-4	2001	The demonstration that the human pathology of FRDA is also characterised by mitochondrial iron accumulation, deficit of respiratory chain complex activities and in vivo deficit of tissue energy metabolism establishes FRDA as a "new" nuclear encoded mitochondrial disease.	Iron	90-94	frataxin	Homo sapiens	46-50
11351132-4	2001	The demonstration that the human pathology of FRDA is also characterised by mitochondrial iron accumulation, deficit of respiratory chain complex activities and in vivo deficit of tissue energy metabolism establishes FRDA as a "new" nuclear encoded mitochondrial disease.	Iron	90-94	frataxin	Homo sapiens	217-221
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	76-80	transferrin receptor	Homo sapiens	22-25
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	146-150	transferrin receptor	Homo sapiens	0-20
16044455-1	2005	Transferrin receptor (TfR) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron-loaded transferrin (Tf).	Iron	146-150	transferrin receptor	Homo sapiens	22-25
16117851-8	2005	Identification of the similar biological functions of FER and AtbHLH29, which isolated from two systematically wide-diverged "strategy I" plants, suggests that FER might be a universal gene presented in all strategy I plants in controlling effective iron acquisition system in roots.	Iron	250-254	bHLH transcriptional regulator	Solanum lycopersicum	160-163
11313312-1	2001	BACKGROUND &amp; AIMS: Overexpression of duodenal divalent metal transporter (DMT1) messenger RNA occurs in hemochromatosis and HFE-knockout mice, suggesting that DMT1 mediates enhanced absorption of iron; however, increased expression of functional DMT1 protein has yet to be substantiated.	Iron	200-204	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	78-82
11313312-1	2001	BACKGROUND &amp; AIMS: Overexpression of duodenal divalent metal transporter (DMT1) messenger RNA occurs in hemochromatosis and HFE-knockout mice, suggesting that DMT1 mediates enhanced absorption of iron; however, increased expression of functional DMT1 protein has yet to be substantiated.	Iron	200-204	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	163-167
11313312-1	2001	BACKGROUND &amp; AIMS: Overexpression of duodenal divalent metal transporter (DMT1) messenger RNA occurs in hemochromatosis and HFE-knockout mice, suggesting that DMT1 mediates enhanced absorption of iron; however, increased expression of functional DMT1 protein has yet to be substantiated.	Iron	200-204	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	163-167
11313312-4	2001	DMT1-specific antibodies were used to block iron transport and to quantify duodenal protein expression.	Iron	44-48	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
11313312-8	2001	CONCLUSIONS: Disruption of the HFE gene up-regulates functional DMT1 transporters and enhances uptake of ferrous iron by this mechanism; DMT1 also mediates increased uptake after reduction of ferric iron presented at physiological concentrations.	Iron	113-117	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	137-141
16102632-1	2005	OBJECTIVE: Chronic venous disease (CVD) is the most common vascular disorder, progressing in approximately 10% of cases toward chronic venous leg ulceration, whereas the hemochromatosis gene (HFE) C282Y mutation is the most common recognized genetic defect in iron metabolism.	Iron	260-264	homeostatic iron regulator	Homo sapiens	192-195
11394651-8	2001	CONCLUSIONS: This study shows that (i) the predicted prevalence for C282Y homozygosity in Italy is 1:3900; (ii) the C282Y/H63D wild-type population has an increased baseline of iron parameters possibly due to genetic factors not linked to the C282Y/H63D mutations; (iii) since in the latter population the actual tissue iron burden cannot be assessed, phenotypic (TS) screening in Italy is not recommended until the true prevalence of all mutations in the HFE gene and in other hemochromatosis genes will be established.	Iron	177-181	homeostatic iron regulator	Homo sapiens	456-459
16129039-15	2005	(2) Both of Fn mRNA and TfR mRNA participated, more or less, in the iron metabolism in HL-60 cells.	Iron	68-72	transferrin receptor	Homo sapiens	24-27
11113132-3	2001	By Northern blot analysis, the corresponding mRNA was confirmed to be overexpressed in livers of experimentally (carbonyl iron and iron-dextran-treated mice) and spontaneously (beta(2)-microglobulin knockout mice) iron-overloaded mice.	Iron	131-135	beta-2 microglobulin	Mus musculus	177-198
11242801-4	2001	In the iron overload cohort, HFE C282Y homozygotes (n = 74) had significantly higher (P &lt; .0001) transferrin saturation levels (74% +/- 25%) than did nonhomozygotes (n = 340; 51.4% +/- 28%), suggesting a genotype-dependent increase in body iron loads.	Iron	7-11	homeostatic iron regulator	Homo sapiens	29-32
11242801-4	2001	In the iron overload cohort, HFE C282Y homozygotes (n = 74) had significantly higher (P &lt; .0001) transferrin saturation levels (74% +/- 25%) than did nonhomozygotes (n = 340; 51.4% +/- 28%), suggesting a genotype-dependent increase in body iron loads.	Iron	243-247	homeostatic iron regulator	Homo sapiens	29-32
16032772-0	2005	Specific aspartate residues in FET3 control high-affinity iron transport in Saccharomyces cerevisiae.	Iron	58-62	ferroxidase FET3	Saccharomyces cerevisiae S288C	31-35
11289442-4	2001	The optical method exploits the natural binding affinity of IRP1 to an iron-responsive element (IRE) which was in vitro transcribed with a linker sequence and subsequently immobilized on a BIACORE sensor chip.	Iron	71-75	aconitase 1	Homo sapiens	60-64
16032772-1	2005	Site-directed mutagenesis was performed on a set of six aspartate residues of Fet3, the multicopper ferroxidase involved in high-affinity iron transport in Saccharomyces cerevisiae, in order to comprehend the molecular determinants of the protein function.	Iron	138-142	ferroxidase FET3	Saccharomyces cerevisiae S288C	78-82
16032772-5	2005	In particular, substitution of Asp320 with asparagine essentially abolished the Fet3-dependent iron transport activity.	Iron	95-99	ferroxidase FET3	Saccharomyces cerevisiae S288C	80-84
15938636-9	2005	The dynamic change of the IRP between different oligomeric and conformational states induced by interaction with IRE may play a role in the iron regulatory functions of IRPs.	Iron	140-144	Wnt family member 2	Homo sapiens	26-29
11500061-8	2001	At univariate analysis, iron overload was significantly associated with both HFE mutations (P &lt; 0.0001), whereas ongoing hepatitis B virus infection was associated with the C282Y mutation (P &lt; 0.05).	Iron	24-28	homeostatic iron regulator	Homo sapiens	77-80
11237510-6	2001	These amounts of Fe and Zn represented 39 and 90% of the NRC requirement for the rat, respectively.	Iron	17-19	nuclear receptor coactivator 6	Rattus norvegicus	57-60
15817488-3	2005	We show that Fet3p and Ftr1p are post-translationally regulated by iron.	Iron	67-71	ferroxidase FET3	Saccharomyces cerevisiae S288C	13-18
11248704-3	2001	During the reaction cycle, adrenodoxin transfers electrons from the FAD of adrenodoxin reductase to the heme iron of the catalytically active cytochrome P450 (P450scc).	Iron	109-113	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	153-157
15817488-4	2005	Incubation of cells in high iron leads to the internalization and degradation of both Fet3p and Ftr1p.	Iron	28-32	ferroxidase FET3	Saccharomyces cerevisiae S288C	86-91
11248704-3	2001	During the reaction cycle, adrenodoxin transfers electrons from the FAD of adrenodoxin reductase to the heme iron of the catalytically active cytochrome P450 (P450scc).	Iron	109-113	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	159-166
15817488-5	2005	Yeast strains defective in endocytosis (Deltaend4) show a reduced iron-induced loss of Fet3p-Ftr1p.	Iron	66-70	ferroxidase FET3	Saccharomyces cerevisiae S288C	87-92
15817488-7	2005	Iron-induced degradation of Fet3p-Ftr1p is significantly reduced in strains containing a deletion of a gene, VTA1, which is involved in multivesicular body (MVB) sorting in yeast.	Iron	0-4	ferroxidase FET3	Saccharomyces cerevisiae S288C	28-33
15817488-10	2005	Iron-induced internalization and degradation of Fet3p-Ftr1p occurs in a mutant strain of the E3 ubiquitin ligase RSP5 (rsp5-1), suggesting that Rsp5p is not required.	Iron	0-4	ferroxidase FET3	Saccharomyces cerevisiae S288C	48-53
11255270-1	2001	BACKGROUND AND OBJECTIVES: Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation.	Iron	131-135	transferrin receptor	Rattus norvegicus	27-47
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	47-51	ferroxidase FET3	Saccharomyces cerevisiae S288C	19-24
11255270-1	2001	BACKGROUND AND OBJECTIVES: Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation.	Iron	131-135	transferrin receptor	Rattus norvegicus	49-52
11255270-5	2001	DESIGN AND METHODS: We measured directly the total number of reticulocyte TfR in normal rats of different age and iron status, as well as in animals experiencing various conditions and treatments aimed at altering erythropoietic activity and iron status, including rHuEpo therapy, hemolytic anemia, phlebotomies, hypertransfusions, thiamphenicol-induced red cell aplasia or inflammation.	Iron	114-118	transferrin receptor	Rattus norvegicus	74-77
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	47-51	ferroxidase FET3	Saccharomyces cerevisiae S288C	80-85
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	47-51	ferroxidase FET3	Saccharomyces cerevisiae S288C	80-85
11179246-6	2001	With the identification of the HFE gene, we are beginning to unravel many of the mysteries of both normal iron absorption and the disorder of iron metabolism found in patients with HH.	Iron	106-110	homeostatic iron regulator	Homo sapiens	31-34
11179246-6	2001	With the identification of the HFE gene, we are beginning to unravel many of the mysteries of both normal iron absorption and the disorder of iron metabolism found in patients with HH.	Iron	142-146	homeostatic iron regulator	Homo sapiens	31-34
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	136-140	ferroxidase FET3	Saccharomyces cerevisiae S288C	19-24
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	136-140	ferroxidase FET3	Saccharomyces cerevisiae S288C	80-85
11425282-8	2001	Moreover, the high levels of Fe found in the substantia nigra of PD patients may perhaps be explained by free Cu binding to iron binding protein-1 (IBP-1), causing it to malfunction and preventing it from detaching itself from the transferrin receptor (TfR) inhibition gene, resulting in expression of TfR even when the cell has plenty of Fe.	Iron	29-31	transferrin receptor	Homo sapiens	231-251
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	136-140	ferroxidase FET3	Saccharomyces cerevisiae S288C	80-85
11425282-8	2001	Moreover, the high levels of Fe found in the substantia nigra of PD patients may perhaps be explained by free Cu binding to iron binding protein-1 (IBP-1), causing it to malfunction and preventing it from detaching itself from the transferrin receptor (TfR) inhibition gene, resulting in expression of TfR even when the cell has plenty of Fe.	Iron	29-31	transferrin receptor	Homo sapiens	253-256
27264664-7	2005	Also there was a statistically significant increase of ristocetin cofactor activities and FXI levels after iron repletion.	Iron	107-111	coagulation factor XI	Homo sapiens	90-93
11425282-8	2001	Moreover, the high levels of Fe found in the substantia nigra of PD patients may perhaps be explained by free Cu binding to iron binding protein-1 (IBP-1), causing it to malfunction and preventing it from detaching itself from the transferrin receptor (TfR) inhibition gene, resulting in expression of TfR even when the cell has plenty of Fe.	Iron	29-31	transferrin receptor	Homo sapiens	302-305
15834437-2	2005	Since the liver is a major site of iron deposition in HFE-associated hemochromatosis, and iron has oxidative toxicity, we hypothesized that HFE genotype might influence the risk of HVOD after myeloablative HSCT.	Iron	35-39	homeostatic iron regulator	Homo sapiens	140-143
11175786-3	2001	Yeast knockout models as well as histological and biochemical data from heart biopsies or autopsies of FRDA patients have shown that frataxin defects cause a specific iron-sulfur protein deficiency and intramitochondrial iron accumulation.	Iron	167-171	frataxin	Homo sapiens	133-141
11175786-6	2001	Our models demonstrate time-dependent intramitochondrial iron accumulation in a frataxin-deficient mammal, which occurs after onset of the pathology and after inactivation of the Fe-S-dependent enzymes.	Iron	57-61	frataxin	Homo sapiens	80-88
11175786-6	2001	Our models demonstrate time-dependent intramitochondrial iron accumulation in a frataxin-deficient mammal, which occurs after onset of the pathology and after inactivation of the Fe-S-dependent enzymes.	Iron	179-181	frataxin	Homo sapiens	80-88
11175792-2	2001	Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC).	Iron	116-120	transferrin receptor	Mus musculus	219-239
11175792-2	2001	Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC).	Iron	116-120	transferrin receptor	Mus musculus	241-245
15834437-2	2005	Since the liver is a major site of iron deposition in HFE-associated hemochromatosis, and iron has oxidative toxicity, we hypothesized that HFE genotype might influence the risk of HVOD after myeloablative HSCT.	Iron	90-94	homeostatic iron regulator	Homo sapiens	140-143
15857638-4	2005	Their BET surface areas were around two orders higher than those of commercial micro-scale Fe and Zn particles.	Iron	91-93	delta/notch like EGF repeat containing	Homo sapiens	6-9
11035018-0	2001	Adrenodoxin reductase homolog (Arh1p) of yeast mitochondria required for iron homeostasis.	Iron	73-77	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	31-36
11035018-7	2001	Exposure of Arh1p-depleted cells to increasing iron concentrations during growth led to drastic increases in mitochondrial iron, indicating a loss of homeostatic control.	Iron	47-51	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	12-17
11035018-7	2001	Exposure of Arh1p-depleted cells to increasing iron concentrations during growth led to drastic increases in mitochondrial iron, indicating a loss of homeostatic control.	Iron	123-127	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	12-17
11035018-10	2001	Finally, a time course correlated the cellular depletion of Arh1p with the coordinated appearance of various mutant phenotypes including dysregulated cellular iron uptake, deficiency of Fe-S protein activities in mitochondria and cytoplasm, and deficiency of hemoproteins.	Iron	159-163	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	60-65
11035018-11	2001	Thus, Arh1p is required for control of cellular and mitochondrial iron levels and for the activities of Fe-S cluster proteins.	Iron	66-70	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	6-11
11035018-11	2001	Thus, Arh1p is required for control of cellular and mitochondrial iron levels and for the activities of Fe-S cluster proteins.	Iron	104-108	NADPH-adrenodoxin reductase	Saccharomyces cerevisiae S288C	6-11
15886110-2	2005	Recently, CD1 proteins have been found to present mycobacterial lipopeptides that are involved in scavenging iron from infected cells.	Iron	109-113	CD1c molecule	Homo sapiens	10-13
15925311-3	2005	We have found that iron represses transcription of RIB1 and RIB7 genes coding for the first and the last enzymes of RF biosynthesis in the model flavinogenic organism Pichia guilliermondii.	Iron	19-23	GTP cyclohydrolase II	Saccharomyces cerevisiae S288C	51-55
11134514-11	2001	These data indicate that iron overload alone is sufficient to reduce URO-D activity to rate-limiting levels in URO-D(+/-) mice.	Iron	25-29	uroporphyrinogen decarboxylase	Mus musculus	69-74
11134514-11	2001	These data indicate that iron overload alone is sufficient to reduce URO-D activity to rate-limiting levels in URO-D(+/-) mice.	Iron	25-29	uroporphyrinogen decarboxylase	Mus musculus	111-116
11134514-12	2001	The URO-D(+/-) mouse serves as an excellent model of familial PCT and affords the opportunity to define the mechanism by which iron influences URO-D activity.	Iron	127-131	uroporphyrinogen decarboxylase	Mus musculus	4-9
11134514-12	2001	The URO-D(+/-) mouse serves as an excellent model of familial PCT and affords the opportunity to define the mechanism by which iron influences URO-D activity.	Iron	127-131	uroporphyrinogen decarboxylase	Mus musculus	143-148
15925311-9	2005	Using the rib1-86 mutant as parental strain, a collection of mutants able to grow in iron-sufficient medium without exogenous RF has been isolated.	Iron	85-89	GTP cyclohydrolase II	Saccharomyces cerevisiae S288C	10-14
11190796-3	2001	By using receiver operating characteristic curve analysis, the diagnostic accuracy of the various indicators of iron status that we evaluated for discriminating between IDA and ACD decreased in the following order: TIBC &gt; TfR &gt; MCV &gt; (%TS = RDW) &gt; SIC.	Iron	112-116	transferrin receptor	Homo sapiens	225-228
15925311-11	2005	Study of one corresponding mutant, red6, showed derepression of RIB1 mRNA synthesis in iron-sufficient medium.	Iron	87-91	GTP cyclohydrolase II	Saccharomyces cerevisiae S288C	64-68
15917086-0	2005	The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase.	Iron	48-52	phenylalanine hydroxylase	Homo sapiens	94-119
11234996-4	2001	Cells cultured with increasing concentrations of iron increased both total intracellular iron and the reactive iron pool, despite an active IRE/IRP system, which regulates intracellular iron levels.	Iron	49-53	Wnt family member 2	Homo sapiens	144-147
15917086-13	2005	On the other hand, compared to wild-type PAH, Y325L shows reduced specific activity, decreased coupling efficiency and decreased iron content.	Iron	129-133	phenylalanine hydroxylase	Homo sapiens	41-44
15917086-16	2005	Tyr325 thus appears to have an important role ensuring stoichiometric binding of iron, correct geometry of the complexes with substrate and cofactor and, consequently, a right coupling efficiency of the PAH reaction.	Iron	81-85	phenylalanine hydroxylase	Homo sapiens	203-206
16175162-9	2005	The identification of mutations of HFE and of other genes involved in the disease has allowed to develop molecular tests to support early diagnosis, allowing also to ameliorate the differential diagnosis with other iron loading disorders.	Iron	215-219	homeostatic iron regulator	Homo sapiens	35-38
11188526-3	2000	Increasing alpha-substitution leads to the lengthening of the Fe-N bond, which in turn results in a change in carboxylate binding mode from eta 1 to eta 2.	Iron	62-64	DNA polymerase iota	Homo sapiens	149-154
11027676-1	2000	The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	73-77	transferrin receptor	Homo sapiens	4-24
11027676-1	2000	The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	73-77	transferrin receptor	Homo sapiens	26-29
11027676-1	2000	The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.	Iron	73-77	homeostatic iron regulator	Homo sapiens	111-114
11027676-10	2000	The affinity of TfR2 for iron-loaded Tf was determined to be 27 nm, 25-fold lower than the affinity of TfR for Tf.	Iron	25-29	transferrin receptor	Homo sapiens	16-19
16092755-2	2005	With this improved knockout system, we inactivated sitC gene, which is associated with iron transport in Shigella flexneri 2a strain 301, to yield the mutant, MTS.	Iron	87-91	sitC	Shigella flexneri 2a str. 301	51-55
11027676-11	2000	These results imply that HFE regulates Tf-mediated iron uptake only from the classical TfR and that TfR2 does not compete for HFE binding in cells expressing both forms of TfR.	Iron	51-55	homeostatic iron regulator	Homo sapiens	25-28
11085915-3	2000	Iron homoeostasis is controlled through several genes, an increasing number of which have been found to contain non-coding sequences [i.e. the iron-responsive elements (IREs)] which are recognized at the mRNA level by two cytoplasmic iron-regulatory proteins (IRP-1 and IRP-2).	Iron	0-4	aconitase 1	Homo sapiens	260-265
15893546-2	2005	This study was designed to test the hypothesis that manganese exposure may change the binding affinity of iron regulatory proteins (IRPs) to mRNAs encoding transferrin receptor (TfR), thereby influencing iron transport at the blood-CSF barrier.	Iron	106-110	transferrin receptor	Homo sapiens	156-176
15893546-2	2005	This study was designed to test the hypothesis that manganese exposure may change the binding affinity of iron regulatory proteins (IRPs) to mRNAs encoding transferrin receptor (TfR), thereby influencing iron transport at the blood-CSF barrier.	Iron	106-110	transferrin receptor	Homo sapiens	178-181
11122155-2	2000	Studies performed before the discovery of the haemochromatosis gene (HFE) have yielded conflicting results: some suggest that iron overload might arise from the interaction of the beta-thalassaemia trait with heterozygosity for haemochromatosis, some with homozygosity for haemochromatosis and others that it was unrelated to haemochromatosis.	Iron	126-130	homeostatic iron regulator	Homo sapiens	69-72
11122155-5	2000	We suggest that the coexistence of the beta-thalassaemia trait might also increase the risk of iron overload in patients with HFE genotypes at a mild risk of haemochromatosis.	Iron	95-99	homeostatic iron regulator	Homo sapiens	126-129
15893546-10	2005	Taken together, these results suggest that manganese exposure increases iron transport at the blood-CSF barrier; the effect is likely due to manganese action on translational events relevant to the production of TfR, but not due to its action on transcriptional, gene expression of TfR.	Iron	72-76	transferrin receptor	Homo sapiens	212-215
15636585-1	2005	In iron-starved cells, IRP1 (iron regulatory protein 1) binds to mRNA iron-responsive elements and controls their translation or stability.	Iron	3-7	aconitase 1	Homo sapiens	23-27
11205697-0	2000	Evaluation of iron status in anemic patients with rheumatoid arthritis using an automated immunoturbidimetric assay for transferrin receptor.	Iron	14-18	transferrin receptor	Homo sapiens	120-140
11205697-5	2000	Now, that assays which are suitable for automated analyzers have become available for the measurement of serum transferrin receptor, this analyte has the potential to become a part of the routine evaluation of iron status.	Iron	210-214	transferrin receptor	Homo sapiens	111-131
11078817-3	2000	Also the current literature on the role of HFE in iron absorption and transport at a molecular level and how mutations in HFE may lead to the break down in the regulation of iron homeostasis is reviewed.	Iron	50-54	homeostatic iron regulator	Homo sapiens	43-46
15636585-1	2005	In iron-starved cells, IRP1 (iron regulatory protein 1) binds to mRNA iron-responsive elements and controls their translation or stability.	Iron	3-7	aconitase 1	Homo sapiens	29-54
11078817-3	2000	Also the current literature on the role of HFE in iron absorption and transport at a molecular level and how mutations in HFE may lead to the break down in the regulation of iron homeostasis is reviewed.	Iron	174-178	homeostatic iron regulator	Homo sapiens	122-125
15636585-1	2005	In iron-starved cells, IRP1 (iron regulatory protein 1) binds to mRNA iron-responsive elements and controls their translation or stability.	Iron	29-33	aconitase 1	Homo sapiens	23-27
15636585-2	2005	In response to increased iron levels, RNA-binding is inhibited on assembly of a cubane [4Fe-4S] cluster, which renders IRP1 to a cytosolic aconitase.	Iron	25-29	aconitase 1	Homo sapiens	119-123
15952393-5	2005	Nitrogen adsorption-desorption analyses showed the BET specific surface area, total pore volume, porosity, and average mesoporous diameter all decreased with iron impregnation, indicating that some micropores were blocked.	Iron	158-162	delta/notch like EGF repeat containing	Homo sapiens	51-54
11092755-0	2000	Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.	Iron	15-19	huntingtin	Homo sapiens	0-10
11092755-3	2000	Although the majority did not differ, dramatic changes in six classes revealed that huntingtin"s function is essential for the normal nuclear (nucleoli, transcription factor-speckles) and perinuclear membrane (mitochondria, endoplasmic reticulum, Golgi and recycling endosomes) organelles and for proper regulation of the iron pathway.	Iron	322-326	huntingtin	Homo sapiens	84-94
11191743-2	2000	New speculations have appeared on the possible relation of this role of iron and the occurrence of mutation of the recently discovered gene of the hereditary hemochromatosis HFE, which may cause the iron overloading of the organism.	Iron	72-76	homeostatic iron regulator	Homo sapiens	174-177
11191743-2	2000	New speculations have appeared on the possible relation of this role of iron and the occurrence of mutation of the recently discovered gene of the hereditary hemochromatosis HFE, which may cause the iron overloading of the organism.	Iron	199-203	homeostatic iron regulator	Homo sapiens	174-177
15849611-0	2005	Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver.	Iron	35-39	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-7
11053528-8	2000	These experiments provide supporting evidence that elevated levels of extracellular DA in the striatum of iron-deficient rats is likely to be the result of decreased DAT functioning and not increased rates of release.	Iron	106-110	solute carrier family 6 member 3	Rattus norvegicus	166-169
15849611-1	2005	Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake.	Iron	71-75	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-34
15849611-1	2005	Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake.	Iron	71-75	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	36-43
11132229-12	2000	CONCLUSION: These clinical features observed in patients with beta-thalassemia/Hb E are probably the results of chronic anemia and iron overload.	Iron	131-135	hemoglobin subunit epsilon 1	Homo sapiens	79-83
15849611-1	2005	Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake.	Iron	121-125	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-34
15849611-1	2005	Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake.	Iron	121-125	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	36-43
15849611-5	2005	We found that fetal Slc11a2 is not needed for materno-fetal iron transfer but that Slc11a2 activity is essential for intestinal non-heme iron absorption after birth.	Iron	137-141	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	83-90
11096344-2	2000	The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron.	Iron	238-242	homeostatic iron regulator	Homo sapiens	18-21
11096344-2	2000	The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron.	Iron	238-242	transferrin receptor	Homo sapiens	50-70
15849611-8	2005	We previously showed that Slc11a2 serves as the primary portal for intestinal iron entry in hemochromatosis.	Iron	78-82	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	26-33
11096344-2	2000	The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron.	Iron	238-242	homeostatic iron regulator	Homo sapiens	86-89
11096344-2	2000	The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron.	Iron	238-242	transferrin receptor	Homo sapiens	173-176
16566123-2	2005	It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion.	Iron	24-28	ferroxidase FET3	Saccharomyces cerevisiae S288C	129-133
11202048-14	2000	In the absence of iron, to be incorporated in the porphyrin formed in the last step of the synthesis, the mRNA of erythroid 5-aminolevulinate synthase (ALAS-2) is blocked by attachment of an iron-responsive element (IRE) binding cytosolic protein, and transcription of this key enzyme is inhibited.	Iron	18-22	5'-aminolevulinate synthase 2	Homo sapiens	152-158
11202048-14	2000	In the absence of iron, to be incorporated in the porphyrin formed in the last step of the synthesis, the mRNA of erythroid 5-aminolevulinate synthase (ALAS-2) is blocked by attachment of an iron-responsive element (IRE) binding cytosolic protein, and transcription of this key enzyme is inhibited.	Iron	191-195	5'-aminolevulinate synthase 2	Homo sapiens	152-158
16566123-2	2005	It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion.	Iron	179-183	ferroxidase FET3	Saccharomyces cerevisiae S288C	129-133
16566123-6	2005	The information regards to participation of siderophores and metal-proton plasma membrane exchangers Smf1 in iron transport is brought.	Iron	109-113	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	101-105
15794764-3	2005	When rPf1-Cys-Prx was added to GSH-mediated FP degradation, the amount of iron released was reduced to 23% of the reaction without the protein (P &lt; 0.01).	Iron	74-78	ribosome production factor 1	Rattus norvegicus	5-9
11035806-3	2000	The homologue of frataxin in yeast, YFH1, is required for cellular respiration and was suggested to regulate mitochondrial iron homeostasis.	Iron	123-127	frataxin	Homo sapiens	17-25
15794764-7	2005	The findings of the present study suggest that Pf1-Cys-Prx protects the parasite against oxidative stresses by binding to FP, slowing the rate of GSH-mediated FP degradation and consequent iron generation, protecting proteins from iron-derived reactive oxygen species, and interfering with formation of membrane-associated FP.	Iron	189-193	PHD finger protein 12	Homo sapiens	47-50
10889193-1	2000	Intracellular iron homeostasis is regulated, in part, by interactions between iron-regulatory proteins (IRP1 and IRP2) and iron-responsive elements (IREs) in ferritin and transferrin receptor mRNAs.	Iron	78-82	aconitase 1	Rattus norvegicus	104-108
15794764-7	2005	The findings of the present study suggest that Pf1-Cys-Prx protects the parasite against oxidative stresses by binding to FP, slowing the rate of GSH-mediated FP degradation and consequent iron generation, protecting proteins from iron-derived reactive oxygen species, and interfering with formation of membrane-associated FP.	Iron	231-235	PHD finger protein 12	Homo sapiens	47-50
15792797-4	2005	Furthermore, iron-treatment increased levels of DMT1 co-localised with LAMP1, suggesting that the initial response of intestinal epithelial cells to iron involves internalisation and targeting of DMT1 transporter protein towards a late endosomal/lysosomal compartment.	Iron	13-17	lysosomal associated membrane protein 1	Homo sapiens	71-76
11229359-2	2000	FRDA patients have characteristic iron deposits and dysfunction of mitochondrial enzymes in the heart.	Iron	34-38	frataxin	Homo sapiens	0-4
10930361-4	2000	Increased iron deposition and evidence of oxidative damage have also been observed in cardiac tissue and cultured fibroblasts from patients with FRDA.	Iron	10-14	frataxin	Homo sapiens	145-149
15637066-2	2005	In the present study, we demonstrate that HGF stimulates epithelial cells to express neutrophil gelatinase-associated lipocalin (Ngal), a member of the lipocalin family of secreted proteins that has recently been shown to participate in mesenchymal-epithelial transformation via its ability to augment cellular iron uptake.	Iron	311-315	hepatocyte growth factor	Homo sapiens	42-45
15522954-7	2005	In addition, iron inserted into MtFt was less available for chelation than that in cytosolic ferritin and the expression of MtFt was associated with decreased mitochondrial and cytosolic aconitase activities, the latter being consistent with the increase in IRP-binding activity.	Iron	13-17	wingless-type MMTV integration site family, member 2	Mus musculus	258-261
11019827-1	2000	We have previously reported several studies on the loading of iron into ferritin by ceruloplasmin using proteins from rats.	Iron	62-66	ceruloplasmin	Rattus norvegicus	84-97
11020014-0	2000	HFE mutations in insulin resistance-associated hepatic iron overload.	Iron	55-59	homeostatic iron regulator	Homo sapiens	0-3
15528311-7	2005	Studies examining the disease Friedreich ataxia have suggested that a mutation in the gene encoding frataxin leads to mitochondrial Fe loading.	Iron	132-134	frataxin	Homo sapiens	100-108
10942923-11	2000	However, we can not rule out that a tissue specific regulation of HFE expression in the cells directly involved in iron absorption is altered and contributes to the pathogenesis of the disease.	Iron	115-119	homeostatic iron regulator	Homo sapiens	66-69
15713745-5	2005	We examined the effect of PEDF on kinase activity of Fyn and found that PEDF downregulated FGF-2-promoted Fyn activity by tyrosine phosphorylation at the C-terminus in a Fes-dependent manner.	Iron	170-173	fibroblast growth factor 2	Mus musculus	91-96
15711640-1	2005	Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe).	Iron	99-103	lipocalin 2	Mus musculus	0-42
10956153-0	2000	Genetic selection for enhanced bioavailable levels of iron in bean (Phaseolus vulgaris L.) seeds.	Iron	54-58	brain expressed, associated with NEDD4, 1	Rattus norvegicus	62-66
10920253-9	2000	These findings suggest a unique heme environment of P450(SPalpha), in which most compounds usually acting as external ligands of ferric P450s are prevented from gaining access to the heme iron of P450(SPalpha).	Iron	40-44	CD5 molecule like	Homo sapiens	52-64
10920253-9	2000	These findings suggest a unique heme environment of P450(SPalpha), in which most compounds usually acting as external ligands of ferric P450s are prevented from gaining access to the heme iron of P450(SPalpha).	Iron	40-44	CD5 molecule like	Homo sapiens	196-208
15711640-1	2005	Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe).	Iron	99-103	lipocalin 2	Mus musculus	44-48
15711640-1	2005	Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe).	Iron	99-103	lipocalin 2	Mus musculus	126-130
15711640-1	2005	Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe).	Iron	143-145	lipocalin 2	Mus musculus	0-42
15711640-1	2005	Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe).	Iron	143-145	lipocalin 2	Mus musculus	44-48
10861683-1	2000	Mutations in the class I-like major histocompatibility complex gene called HFE are associated with hereditary hemochromatosis (HHC), a disorder of excessive iron uptake.	Iron	157-161	homeostatic iron regulator	Homo sapiens	75-78
15711640-1	2005	Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe).	Iron	143-145	lipocalin 2	Mus musculus	126-130
15711640-3	2005	In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage.	Iron	62-64	lipocalin 2	Mus musculus	45-49
15711640-7	2005	The Ngal:siderophore:Fe complex upregulates heme oxygenase-1, a protective enzyme, preserves proximal tubule N-cadherin, and inhibits cell death.	Iron	21-23	lipocalin 2	Mus musculus	4-8
15710243-10	2005	However, the activities of IRP1 and IRP2, and protein levels of TfR1 and ferritin, were still significantly lower in iron-depleted ScN2a cells as compared to the N2a cells, suggesting lower need for iron in ScN2a cells.	Iron	199-203	sodium channel, voltage-gated, type II, alpha	Mus musculus	207-212
10892882-20	2000	In contrast, Tf, mainly synthesized by RPE cells and detected in OS and IS areas, probably helps to transport iron to photoreceptors through their Tf-R.	Iron	110-114	transferrin receptor	Rattus norvegicus	147-151
15517265-1	2005	Type 1 hemochromatosis is a disorder of iron metabolism mostly related to the HFE gene mutations.	Iron	40-44	homeostatic iron regulator	Homo sapiens	78-81
11001096-8	2000	We have generated a mutant of MnSOD with the active site Gln in the location characteristic of Fe-specific SODs.	Iron	95-97	superoxide dismutase 2	Homo sapiens	30-35
11001096-10	2000	However, the mutant"s Fe-supported activity is at least 7% that of FeSOD, in contrast to Fe(Mn)SOD, which has 0% of FeSOD"s activity.	Iron	22-24	superoxide dismutase 2	Homo sapiens	69-72
15667273-0	2005	Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis.	Iron	102-106	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	0-5
10924274-6	2000	We hypothesize that the lesions in NPC1 and NPC2 block the intracellular utilization not only of cholesterol, but also that of iron for the synthesis of cytosolic ferritin.	Iron	127-131	NPC intracellular cholesterol transporter 2	Homo sapiens	44-48
15667273-2	2005	Previously, we have shown that Nar1p is an Fe-S protein and that assembly of its co-factors depends on the mitochondrial Fe-S cluster biosynthesis apparatus.	Iron	43-47	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	31-36
15667273-3	2005	Using functional studies in vivo, we demonstrated that Nar1p has an essential role in the maturation of cytosolic and nuclear, but not of mitochondrial, Fe-S proteins.	Iron	153-157	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	55-60
10781607-1	2000	IscS, a cysteine desulfurase implicated in the repair of Fe-S clusters, was recently shown to act as a sulfurtransferase in the biosynthesis of 4-thiouridine (s(4)U) in tRNA (Kambampati, R., and Lauhon, C. T. (1999) Biochemistry 38, 16561-16568).	Iron	57-61	NFS1 cysteine desulfurase	Homo sapiens	0-4
10781607-14	2000	Thus, IscS plays a significant and specific role at the top of a potentially broad sulfur transfer cascade that is required for the biosynthesis of thiamin, NAD, Fe-S clusters, and thionucleosides.	Iron	162-166	NFS1 cysteine desulfurase	Homo sapiens	6-10
15667273-4	2005	Here we provide further spectroscopic evidence that Nar1p possesses two Fe-S clusters.	Iron	72-76	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	52-57
15667273-5	2005	We also show that Nar1p is required for Fe-S cluster assembly on the P-loop NTPase Nbp35p, another newly identified component of the cytosolic Fe-S protein assembly machinery.	Iron	40-44	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	18-23
10751545-0	2000	Protection of erythrocytes against oxidative damage and autologous immunoglobulin G (IgG) binding by iron chelator fluor-benzoil-pyridoxal hydrazone.	Iron	101-105	immunoglobulin heavy variable V1-62	Mus musculus	67-83
10751545-0	2000	Protection of erythrocytes against oxidative damage and autologous immunoglobulin G (IgG) binding by iron chelator fluor-benzoil-pyridoxal hydrazone.	Iron	101-105	immunoglobulin heavy variable V1-62	Mus musculus	85-88
15667273-5	2005	We also show that Nar1p is required for Fe-S cluster assembly on the P-loop NTPase Nbp35p, another newly identified component of the cytosolic Fe-S protein assembly machinery.	Iron	143-147	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	18-23
15623549-3	2005	On the contrary, the fourth one, HLA-H, named HFE after it was found to be mutated in patients suffering from inherited hemochromatosis, has been shown to be involved only in the regulation of iron uptake.	Iron	193-197	homeostatic iron regulator	Homo sapiens	46-49
10805340-2	2000	Decreases in cytosolic iron induce expression of the transferrin receptor, some of which is released into the serum.	Iron	23-27	transferrin receptor	Homo sapiens	53-73
10805340-3	2000	Here, we demonstrate that serum transferrin receptor concentrations are increased in patients with Friedreich ataxia, which supports the hypothesis that it is a disease of abnormal intracellular iron distribution.	Iron	195-199	transferrin receptor	Homo sapiens	32-52
15673318-1	2005	BACKGROUND: The prevalence of iron overload and the influence of mutations in the HFE and TRF2 gene on biochemical markers of iron overload among renal transplant patients is unknown.	Iron	126-130	homeostatic iron regulator	Homo sapiens	82-85
10769179-7	2000	AtNramp1 and OsNramp1 are able to complement the fet3fet4 yeast mutant defective both in low- and high-affinity iron transports, whereas AtNramp2 and OsNramp2 fail to do so.	Iron	112-116	ferroxidase FET3	Saccharomyces cerevisiae S288C	49-57
15673318-5	2005	Mutations in the HFE gene were present in 12 of 33 (36.3%) patients with iron overload.	Iron	73-77	homeostatic iron regulator	Homo sapiens	17-20
15670845-0	2005	The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake.	Iron	41-45	LDL receptor related protein 2	Homo sapiens	23-30
10785444-0	2000	GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide.	Iron	73-77	glial cell derived neurotrophic factor	Rattus norvegicus	0-4
15581888-1	2005	The mitochondrial protein frataxin is emerging as a novel mechanism to promote iron metabolism while also providing anti-oxidant protection.	Iron	79-83	frataxin	Homo sapiens	26-34
10791995-1	2000	Hereditary hemochromatosis (HH) is a prevalent human disease caused by a mutation in HFE, which encodes an atypical HLA class I protein involved in regulation of intestinal iron absorption.	Iron	173-177	homeostatic iron regulator	Homo sapiens	85-88
10791995-4	2000	Hfe knockout mice carrying mutations in the iron transporter DMT1 fail to load iron, indicating that hemochromatosis involves iron flux through DMT1.	Iron	44-48	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	61-65
10791995-5	2000	Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well.	Iron	82-86	hephaestin	Mus musculus	54-64
10791995-5	2000	Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well.	Iron	82-86	hephaestin	Mus musculus	66-70
10791995-5	2000	Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well.	Iron	138-142	hephaestin	Mus musculus	54-64
15581888-8	2005	Biochemical analyses further reveal that, unlike the prokaryotic and yeast frataxin homologues, which require iron-protein interactions for assembly, human frataxin uses stable subunit-subunit interactions involving a non-conserved amino-terminal region.	Iron	110-114	frataxin	Homo sapiens	156-164
10791995-5	2000	Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well.	Iron	138-142	hephaestin	Mus musculus	66-70
10791995-5	2000	Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well.	Iron	138-142	hephaestin	Mus musculus	198-202
15628844-1	2005	Diphtheria toxin repressor (DtxR) regulates the expression of iron-sensitive genes in Corynebacterium diphtheriae, including the diphtheria toxin gene.	Iron	62-66	MarR family transcriptional regulator	Corynebacterium diphtheriae	0-26
10845668-0	2000	Increased incidence of HFE C282Y mutations in patients with iron overload and hepatocellular carcinoma developed in non-cirrhotic liver.	Iron	60-64	homeostatic iron regulator	Homo sapiens	23-26
15628844-1	2005	Diphtheria toxin repressor (DtxR) regulates the expression of iron-sensitive genes in Corynebacterium diphtheriae, including the diphtheria toxin gene.	Iron	62-66	MarR family transcriptional regulator	Corynebacterium diphtheriae	28-32
15389541-2	2005	A non-classical class I MHC molecule, the hemochromatosis factor (HFE), has been shown to regulate iron metabolism, potentially via its interaction with the transferrin receptor.	Iron	99-103	transferrin receptor	Mus musculus	157-177
10844648-5	2000	Antibody production against FetA commonly occurs in infected patients, and we therefore hypothesize that phase variation reflects a balance between the advantages of being able to use a ferric siderophore as an iron source and evasion of the host immune response.	Iron	211-215	ATPase phospholipid transporting 8B5, pseudogene	Homo sapiens	28-32
10788627-6	2000	These results provide new insights in the mechanism of iron binding and oxidation by Fet3, establishing the essential role of Glu-185 and Tyr-354, and allowing to dissect ferroxidase from non-iron oxidase activity.	Iron	55-59	ferroxidase FET3	Saccharomyces cerevisiae S288C	85-89
15623846-4	2005	Mean values for TfR outcomes were higher among women classified as Fe deficient than those who were Fe sufficient, but did not differ with low or normal blood folate concentrations.	Iron	67-69	transferrin receptor	Homo sapiens	16-19
10766782-3	2000	In this work, we observed that addition of iron improved the respiratory growth of the sod1 mutant and in glucose medium total intracellular iron content was higher in the sod1 mutant than in wild type cells.	Iron	141-145	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	172-176
15623846-4	2005	Mean values for TfR outcomes were higher among women classified as Fe deficient than those who were Fe sufficient, but did not differ with low or normal blood folate concentrations.	Iron	100-102	transferrin receptor	Homo sapiens	16-19
10766782-4	2000	Transcription of the high affinity iron transporter gene, FET3, was enhanced in the sod1 mutant, suggesting that iron transport systems were up-regulated.	Iron	35-39	ferroxidase FET3	Saccharomyces cerevisiae S288C	58-62
10766782-4	2000	Transcription of the high affinity iron transporter gene, FET3, was enhanced in the sod1 mutant, suggesting that iron transport systems were up-regulated.	Iron	35-39	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	84-88
10766782-6	2000	We propose that this increased iron demand in the sod1 mutant may be a reflection of the cells" efforts to reconstitute iron-sulfur cluster-containing enzymes that are continuously inactivated in conditions of excess superoxide.	Iron	31-35	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	50-54
10766782-6	2000	We propose that this increased iron demand in the sod1 mutant may be a reflection of the cells" efforts to reconstitute iron-sulfur cluster-containing enzymes that are continuously inactivated in conditions of excess superoxide.	Iron	120-124	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	50-54
15632449-7	2005	The Mramp-KO phagosome showed a significant increase of P, Ca, Mn, Fe and Zn concentrations between 1 and 24 h after infection, while the concentrations of K and Ni decreased.	Iron	67-69	divalent metal cation transporter MntH	Mycobacterium tuberculosis H37Rv	4-9
10770319-3	2000	Hereditary haemochromatosis due to mutations in the HFE gene leads to increased absorption of iron and multiple end-organ damage.	Iron	94-98	homeostatic iron regulator	Homo sapiens	52-55
16165292-4	2005	Loss of tyrosine hydroxylase expression was accompanied by increased iron and ferritin levels in glial cells of the substantia nigra pars reticulata.	Iron	69-73	tyrosine hydroxylase	Rattus norvegicus	8-28
10762570-5	2000	In contrast to the nonpermissive state, the permissive monocytes had normal transferrin receptor expression and up-regulated transferrin receptor expression appropriately in response to iron-transferrin.	Iron	186-190	transferrin receptor	Homo sapiens	125-145
15610558-3	2004	Primary iron overload unexplained by typical hemochromatosis-associated HFE genotypes is common in white and black adults in Alabama, and HJV I222N and G320V were detected in a white Alabama juvenile hemochromatosis index patient.	Iron	8-12	homeostatic iron regulator	Homo sapiens	72-75
10803694-1	2000	Hereditary hemochromatosis (HFE), which affects 1 in 400 and has an estimated carrier frequency of 1 in 10 individuals in Western population, results in multiple organ damage caused by iron deposition, and is treatable if detected early.	Iron	185-189	homeostatic iron regulator	Homo sapiens	28-31
10981814-2	2000	In order to rationalize the physicochemical properties of human serum-transferrin (STf) and the STf-receptor (TfR) recognition process, we have tried to predict the 3D structures of apo- and iron-loaded STf using a homology modeling technique to study the changes in the structural characteristics that take place upon the uptake of iron by STf in solution.	Iron	191-195	transferrin receptor	Homo sapiens	110-113
10981814-2	2000	In order to rationalize the physicochemical properties of human serum-transferrin (STf) and the STf-receptor (TfR) recognition process, we have tried to predict the 3D structures of apo- and iron-loaded STf using a homology modeling technique to study the changes in the structural characteristics that take place upon the uptake of iron by STf in solution.	Iron	333-337	transferrin receptor	Homo sapiens	110-113
15584735-9	2004	The IR spectra for the carbon monoxide (CO) complex of the reconstituted myoglobin suggest several structural and/or electrostatic conformations of the Fe-C-O bond, but this is not directly correlated with the CO dissociation rate.	Iron	152-154	myoglobin	Physeter catodon	73-82
15584735-10	2004	The high O2 affinity and the unique characteristics of the myoglobin with the iron porphycene indicate that reconstitution with a synthesized heme is a useful method not only to understand the physiological function of myoglobin but also to create a tailor-made function on the protein.	Iron	78-82	myoglobin	Physeter catodon	59-68
10713071-5	2000	CCC1 expression in wild type cells resulted in increased expression of the high affinity iron transport system composed of FET3 and FTR1, suggesting that intracellular iron is not sensed by the iron-dependent transcription factor Aft1p.	Iron	89-93	ferroxidase FET3	Saccharomyces cerevisiae S288C	123-127
15546588-5	2004	One mechanism by which cells fail to properly regulate their iron status is through a mutation in the Hfe gene.	Iron	61-65	homeostatic iron regulator	Homo sapiens	102-105
10694398-1	2000	The Fet3 protein (Fet3p) is a multinuclear copper oxidase essential for high-affinity iron uptake in yeast.	Iron	86-90	ferroxidase FET3	Saccharomyces cerevisiae S288C	4-8
10694398-1	2000	The Fet3 protein (Fet3p) is a multinuclear copper oxidase essential for high-affinity iron uptake in yeast.	Iron	86-90	ferroxidase FET3	Saccharomyces cerevisiae S288C	18-23
15546588-6	2004	Mutations in the Hfe gene are associated with the iron overload disease, hemochromatosis.	Iron	50-54	homeostatic iron regulator	Homo sapiens	17-20
15467009-8	2004	These data bring some evidence of a role of HFE in the liver and a coregulation with erythropoiesis as other genes involved in iron homeostasis.	Iron	127-131	homeostatic iron regulator	Homo sapiens	44-47
17024033-10	2000	Finally, the protein HFE associates with the transferrin receptor and is part of an iron-sensing mechanism that regulates iron absorption.	Iron	84-88	homeostatic iron regulator	Homo sapiens	21-24
17024033-10	2000	Finally, the protein HFE associates with the transferrin receptor and is part of an iron-sensing mechanism that regulates iron absorption.	Iron	84-88	transferrin receptor	Homo sapiens	45-65
17024033-10	2000	Finally, the protein HFE associates with the transferrin receptor and is part of an iron-sensing mechanism that regulates iron absorption.	Iron	122-126	homeostatic iron regulator	Homo sapiens	21-24
17024033-10	2000	Finally, the protein HFE associates with the transferrin receptor and is part of an iron-sensing mechanism that regulates iron absorption.	Iron	122-126	transferrin receptor	Homo sapiens	45-65
15509595-0	2004	Iron-sulfur protein maturation in human cells: evidence for a function of frataxin.	Iron	0-4	frataxin	Homo sapiens	74-82
10698721-11	2000	Because of the associations between iron and lead transport, it is possible that polymorphisms in the HFE gene may also influence the absorption of lead, but this has not yet been studied.	Iron	36-40	homeostatic iron regulator	Homo sapiens	102-105
15509595-8	2004	Hence, iron accumulation in FRDA mitochondria appears to be a late consequence of frataxin deficiency.	Iron	7-11	frataxin	Homo sapiens	28-32
15591282-1	2004	The A16V mitochondrial targeting sequence polymorphism influences the antioxidant activity of MnSOD, an enzyme involved in neutralising iron induced oxidative stress.	Iron	136-140	superoxide dismutase 2	Homo sapiens	94-99
10747413-5	2000	As the calculations reveal, there is little backbonding from the iron to the tin, and the strong sigma donation leads to an increased occupation of the pi-antibonding orbitals of the eta6-arene, which are mainly responsible for the experimentally observed arene lability.	Iron	65-69	endothelin receptor type A	Homo sapiens	183-186
15591282-10	2004	In patients with hereditary haemochromatosis, the MnSOD genotype affects the risk of cardiomyopathy related to iron overload and possibly to other known and unknown risk factors and could represent an iron toxicity modifier gene.	Iron	111-115	superoxide dismutase 2	Homo sapiens	50-55
10772870-4	2000	Immunohistochemical studies have localized the protein product of Hfe to the deep crypts of the duodenum, the maximum site of iron absorption.	Iron	126-130	homeostatic iron regulator	Homo sapiens	66-69
15591282-10	2004	In patients with hereditary haemochromatosis, the MnSOD genotype affects the risk of cardiomyopathy related to iron overload and possibly to other known and unknown risk factors and could represent an iron toxicity modifier gene.	Iron	201-205	superoxide dismutase 2	Homo sapiens	50-55
10655270-3	2000	We also sought to determine the prevalence of HFE mutations in liver transplant patients with iron overload.	Iron	94-98	homeostatic iron regulator	Homo sapiens	46-49
15566515-0	2004	Hepatic iron loading in patients with compound heterozygous HFE mutations.	Iron	8-12	homeostatic iron regulator	Homo sapiens	60-63
10655286-0	2000	Iron beware: a common HFE gene polymorphism may prevent the accurate molecular diagnosis of homozygous hemochromatosis in low-risk, but not high-risk groups.	Iron	0-4	homeostatic iron regulator	Homo sapiens	22-25
10617654-2	2000	We have previously reported that Atox1 in the rat brain is primarily expressed in neurons, with the highest levels in distinct neuronal subtypes that are characterized by their high levels of metal, like copper, iron, and zinc.	Iron	212-216	antioxidant 1 copper chaperone	Rattus norvegicus	33-38
10638746-2	2000	HFE binds to the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded transferrin.	Iron	79-83	homeostatic iron regulator	Homo sapiens	0-3
10638746-2	2000	HFE binds to the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded transferrin.	Iron	79-83	transferrin receptor	Homo sapiens	17-37
10638746-2	2000	HFE binds to the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded transferrin.	Iron	79-83	transferrin receptor	Homo sapiens	39-42
10638746-6	2000	The HFE-TfR complex suggests a binding site for transferrin on TfR and sheds light upon the function of HFE in regulating iron homeostasis.	Iron	122-126	homeostatic iron regulator	Homo sapiens	4-7
10638746-6	2000	The HFE-TfR complex suggests a binding site for transferrin on TfR and sheds light upon the function of HFE in regulating iron homeostasis.	Iron	122-126	transferrin receptor	Homo sapiens	8-11
10638746-6	2000	The HFE-TfR complex suggests a binding site for transferrin on TfR and sheds light upon the function of HFE in regulating iron homeostasis.	Iron	122-126	homeostatic iron regulator	Homo sapiens	104-107
10940348-3	2000	Post-transcriptional control through the action of iron regulatory protein 1 (IRP1) and IRP2 coordinate the use of messenger RNA-encoding proteins that are involved in the uptake, storage, and use of iron in all cells of the body.	Iron	51-55	aconitase 1	Homo sapiens	78-82
10940348-5	2000	Multiple factors, including iron, nitric oxide, oxidative stress, phosphorylation, and hypoxia/reoxygenation, influence IRP function.	Iron	28-32	Wnt family member 2	Homo sapiens	120-123
10605937-5	2000	Signals that target the iso-IRE/iso-IRP interactions in mRNA include environmental iron, O2, nitric oxide, H2O2, ascorbate, growth factors, and protein kinase C-dependent IRP phosphorylation.	Iron	72-76	Wnt family member 2	Homo sapiens	36-39
10605937-7	2000	With the iso-IRE/iso-IRP system, nature has evolved coordinated combinatorial control of iron and oxygen metabolism that may exemplify control of mRNAs in other metabolic pathways, viral reproduction, and oncogenesis.	Iron	89-93	Wnt family member 2	Homo sapiens	21-24
10989540-5	2000	Frataxin, which is deficient in Friedreich"s ataxia, regulates iron flux through mitochondria.	Iron	63-67	frataxin	Homo sapiens	0-8
10989541-4	2000	The link between iron overload and HFE mutation is explained by the interaction between HFE protein, beta-2-microglobulin and transferrin receptor, which is abolished by the C282Y mutation, but is not yet fully understood.	Iron	17-21	homeostatic iron regulator	Homo sapiens	35-38
10989541-4	2000	The link between iron overload and HFE mutation is explained by the interaction between HFE protein, beta-2-microglobulin and transferrin receptor, which is abolished by the C282Y mutation, but is not yet fully understood.	Iron	17-21	homeostatic iron regulator	Homo sapiens	88-91
10972478-3	2000	Dexrazoxane is also known to inhibit topoisomerase II, to prevent the inactivation of cytochrome c oxidase by Fe3+ -doxorubicin and to increase the levels of transferrin receptor (trf-rec) mRNA and cellular iron uptake.	Iron	207-211	transferrin receptor	Homo sapiens	158-178
26368602-6	2000	The iron appears to move from a low-molecular-weight pool to nonferritin proteins and ferritin.	Iron	4-8	ferritin, mitochondrial	Cricetulus griseus	64-72
10610798-1	1999	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin and non-heme iron-dependent enzyme that hydroxylates L-Phe to l-Tyr using molecular oxygen as additional substrate.	Iron	70-74	phenylalanine hydroxylase	Homo sapiens	0-25
10610798-1	1999	Phenylalanine hydroxylase (PAH) is a tetrahydrobiopterin and non-heme iron-dependent enzyme that hydroxylates L-Phe to l-Tyr using molecular oxygen as additional substrate.	Iron	70-74	phenylalanine hydroxylase	Homo sapiens	27-30
10610798-3	1999	The conformation and distances to the catalytic iron of both L-Phe and the cofactor analogue L-erythro-7,8-dihydrobiopterin (BH2) simultaneously bound to recombinant human PAH have been estimated by (1)H NMR.	Iron	48-52	phenylalanine hydroxylase	Homo sapiens	172-175
10610798-6	1999	The mode of coordination of Glu330 to the iron moiety seems to determine the amino acid substrate specificity in PAH and in the homologous enzyme tyrosine hydroxylase.	Iron	42-46	phenylalanine hydroxylase	Homo sapiens	113-116
10816729-6	1999	The gene YHL047c Sce (designated TAF1) was disrupted using the kanMX disruption module in a fet3 background (strain DEY 1394 delta fet3), possessing a defect in the high affinity ferrous iron transport.	Iron	187-191	histone acetyltransferase	Saccharomyces cerevisiae S288C	33-37
10816729-7	1999	Growth promotion assays and transport experiments with 55Fe-labelled triacetylfusarinine C showed a complete loss of iron utilization and uptake in the disrupted strain, indicating that TAF1 is the gene for the fungal triacetylfusarinine transport in Saccharomyces cerevisiae and possibly in other siderophore producing fungi.	Iron	117-121	histone acetyltransferase	Saccharomyces cerevisiae S288C	186-190
10583370-9	1999	These results suggest that the ESR spin-trapping agent Fe-DTCS inhibits NO synthesis by interfering with the physiological electron flow from NADPH to nNOS heme iron.	Iron	161-165	nitric oxide synthase 1, neuronal	Mus musculus	151-155
10666843-6	1999	Mutations of the HFE-protein alter the affinity of the transferrin receptor for its ligand transferrin and may thus cause an intracellular accumulation of iron.	Iron	155-159	homeostatic iron regulator	Homo sapiens	17-20
10570242-6	1999	Unlike the microsomal P-450 reductase, the FMN semiquinone is the active electron donor to the heme iron in P-450(BM-3).	Iron	100-104	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	108-118
10556042-2	1999	HFE binds to transferrin receptor (TfR), the receptor used by cells to obtain iron in the form of diferric transferrin (Fe-Tf).	Iron	78-82	homeostatic iron regulator	Homo sapiens	0-3
10556042-2	1999	HFE binds to transferrin receptor (TfR), the receptor used by cells to obtain iron in the form of diferric transferrin (Fe-Tf).	Iron	78-82	transferrin receptor	Homo sapiens	13-33
10556042-2	1999	HFE binds to transferrin receptor (TfR), the receptor used by cells to obtain iron in the form of diferric transferrin (Fe-Tf).	Iron	78-82	transferrin receptor	Homo sapiens	35-38
10556042-5	1999	The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.	Iron	50-52	homeostatic iron regulator	Homo sapiens	29-32
10539907-7	1999	This direct HFE mutation test can now be used not only to confirm the diagnosis of HH in those with symptomatic disease, but also, perhaps more importantly, to detect those with presymptomatic iron overload in whom future disease manifestations may be prevented (with phlebotomy therapy).	Iron	193-197	homeostatic iron regulator	Homo sapiens	12-15
10556209-9	1999	Extracellular apoferritin taken up by the cell functioned as an iron scavenger: it decreased the level of cellular LIP and increased IRP activity.	Iron	64-68	Wnt family member 2	Homo sapiens	133-136
11671235-2	1999	The results show the potential of stabilizing Fe(VII) and Fe(VIII) in tetrahedral oxo coordination.	Iron	46-48	cytochrome c oxidase subunit 8A	Homo sapiens	61-65
10518614-0	1999	HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation.	Iron	72-76	transferrin receptor	Homo sapiens	29-49
10518614-2	1999	We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation.	Iron	150-154	transferrin receptor	Homo sapiens	79-99
10518614-2	1999	We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation.	Iron	150-154	transferrin receptor	Homo sapiens	101-104
10518614-2	1999	We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation.	Iron	178-182	transferrin receptor	Homo sapiens	79-99
10518614-2	1999	We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation.	Iron	178-182	transferrin receptor	Homo sapiens	101-104
10518614-3	1999	The transcription rate of the TfR gene in isolated nuclei was up-regulated by treatment of Hep3B human hepatoma cells with the iron chelator desferrioxamine (DFO).	Iron	127-131	transferrin receptor	Homo sapiens	30-33
10531064-1	1999	The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome.	Iron	137-141	transferrin receptor	Homo sapiens	4-24
10531064-1	1999	The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome.	Iron	137-141	transferrin receptor	Homo sapiens	26-29
10531064-1	1999	The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome.	Iron	214-218	transferrin receptor	Homo sapiens	4-24
10531064-1	1999	The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome.	Iron	214-218	transferrin receptor	Homo sapiens	26-29
10692770-1	1999	The discovery of the HFE gene has improved classification and diagnosis of iron overload.	Iron	75-79	homeostatic iron regulator	Homo sapiens	21-24
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	14-18	aconitase 1	Homo sapiens	120-124
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	aconitase 1	Homo sapiens	120-124
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	aconitase 1	Homo sapiens	120-124
10522551-2	1999	The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase.	Iron	96-100	aconitase 1	Homo sapiens	120-124
10522552-7	1999	Because the 5"-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells.	Iron	86-90	5'-aminolevulinate synthase 2	Homo sapiens	61-67
10522552-7	1999	Because the 5"-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells.	Iron	196-200	5'-aminolevulinate synthase 2	Homo sapiens	61-67
10522552-7	1999	Because the 5"-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells.	Iron	196-200	5'-aminolevulinate synthase 2	Homo sapiens	61-67
10522553-2	1999	In hereditary hemochromatosis, mutation of an HLA class 1 gene, designated HFE, results in excessive iron absorption.	Iron	101-105	homeostatic iron regulator	Homo sapiens	75-78
10660482-1	1999	The discovery of the C282Y and H63D point mutations in the hereditary hemochromatosis-associated HFE gene allows us to study the molecular basis of congenital and acquired iron overload disorders.	Iron	172-176	homeostatic iron regulator	Homo sapiens	97-100
15566515-1	2004	AIM: To assess the severity of hepatic iron loading in patients with a compound heterozygous C282Y/H63D HFE genotype.	Iron	39-43	homeostatic iron regulator	Homo sapiens	104-107
10660483-2	1999	A recently discovered novel amino acid variant of HFE, namely S65C, has been implicated to be responsible for a mild form of iron overload.	Iron	125-129	homeostatic iron regulator	Homo sapiens	50-53
15566515-3	2004	Subjects of the study were 19 patients compound heterozygous for HFE who had liver biopsy, quantitative liver iron estimation and liver histopathology.	Iron	110-114	homeostatic iron regulator	Homo sapiens	65-68
15566515-5	2004	As well as the compound heterozygous HFE genotype, 18/19 patients were found to have had at least one additional risk factor for developing either iron loading or liver disease.	Iron	147-151	homeostatic iron regulator	Homo sapiens	37-40
15554973-8	2004	Microarray analysis of rim101-/- cells indicated that Rim101p does not govern transcriptional responses at acidic pH, but does regulate a subset of transcriptional responses at alkaline pH, including the iron acquisition genes.	Iron	204-208	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	54-61
10543327-3	1999	The soluble transferrin receptor (sTf-R) is considered as a sensitive and specific indicator of bone marrow iron availability.	Iron	108-112	transferrin receptor	Homo sapiens	12-32
10582331-3	1999	Fleming and colleagues identified mutations in DMT1 (formerly known as Nramp2 and DCT1) in mice and rats with defects in intestinal iron absorption and red blood cell iron utilization.	Iron	132-136	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	47-51
10582331-3	1999	Fleming and colleagues identified mutations in DMT1 (formerly known as Nramp2 and DCT1) in mice and rats with defects in intestinal iron absorption and red blood cell iron utilization.	Iron	132-136	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	71-77
10582331-3	1999	Fleming and colleagues identified mutations in DMT1 (formerly known as Nramp2 and DCT1) in mice and rats with defects in intestinal iron absorption and red blood cell iron utilization.	Iron	132-136	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	82-86
10582331-3	1999	Fleming and colleagues identified mutations in DMT1 (formerly known as Nramp2 and DCT1) in mice and rats with defects in intestinal iron absorption and red blood cell iron utilization.	Iron	167-171	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	47-51
10582331-3	1999	Fleming and colleagues identified mutations in DMT1 (formerly known as Nramp2 and DCT1) in mice and rats with defects in intestinal iron absorption and red blood cell iron utilization.	Iron	167-171	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	71-77
10582331-3	1999	Fleming and colleagues identified mutations in DMT1 (formerly known as Nramp2 and DCT1) in mice and rats with defects in intestinal iron absorption and red blood cell iron utilization.	Iron	167-171	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	82-86
10582342-1	1999	The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to mediate cellular uptake of iron from a plasma glycoprotein, transferrin.	Iron	121-125	transferrin receptor	Homo sapiens	4-24
10582342-8	1999	However, some cells and tissues with specific requirements for iron probably evolved mechanisms that can override the IRE/IRP-dependent control of transferrin receptor expression.	Iron	63-67	Wnt family member 2	Homo sapiens	122-125
10582342-11	1999	Macrophages are another example of a cell type that shows "unorthodox" responses in terms of IRE/IRP paradigm since in these cells elevated iron levels increase (rather than decrease) transferrin receptor mRNA and protein levels.	Iron	140-144	Wnt family member 2	Homo sapiens	97-100
15554973-9	2004	We found that rim101-/- cells are sensitive to iron starvation, which suggests that one important aspect of the Rim101p-dependent alkaline pH response is to adapt to iron starvation conditions.	Iron	47-51	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	14-20
10582342-11	1999	Macrophages are another example of a cell type that shows "unorthodox" responses in terms of IRE/IRP paradigm since in these cells elevated iron levels increase (rather than decrease) transferrin receptor mRNA and protein levels.	Iron	140-144	transferrin receptor	Homo sapiens	184-204
10582343-3	1999	In mammalian systems, control of intracellular iron homeostasis is largely due to posttranscriptional regulation of binding by iron-regulatory RNA-binding proteins (IRPs) to iron-responsive elements (IREs) within ferritin and transferrin receptor (TfR) mRNAs.	Iron	47-51	transferrin receptor	Homo sapiens	226-246
15554973-9	2004	We found that rim101-/- cells are sensitive to iron starvation, which suggests that one important aspect of the Rim101p-dependent alkaline pH response is to adapt to iron starvation conditions.	Iron	47-51	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	112-119
10582343-3	1999	In mammalian systems, control of intracellular iron homeostasis is largely due to posttranscriptional regulation of binding by iron-regulatory RNA-binding proteins (IRPs) to iron-responsive elements (IREs) within ferritin and transferrin receptor (TfR) mRNAs.	Iron	47-51	transferrin receptor	Homo sapiens	248-251
10582343-3	1999	In mammalian systems, control of intracellular iron homeostasis is largely due to posttranscriptional regulation of binding by iron-regulatory RNA-binding proteins (IRPs) to iron-responsive elements (IREs) within ferritin and transferrin receptor (TfR) mRNAs.	Iron	127-131	transferrin receptor	Homo sapiens	226-246
15554973-9	2004	We found that rim101-/- cells are sensitive to iron starvation, which suggests that one important aspect of the Rim101p-dependent alkaline pH response is to adapt to iron starvation conditions.	Iron	166-170	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	14-20
10582343-3	1999	In mammalian systems, control of intracellular iron homeostasis is largely due to posttranscriptional regulation of binding by iron-regulatory RNA-binding proteins (IRPs) to iron-responsive elements (IREs) within ferritin and transferrin receptor (TfR) mRNAs.	Iron	127-131	transferrin receptor	Homo sapiens	248-251
10582343-4	1999	the TfR transports iron into cells and the iron is subsequently stored within ferritin.	Iron	19-23	transferrin receptor	Homo sapiens	4-7
15554973-9	2004	We found that rim101-/- cells are sensitive to iron starvation, which suggests that one important aspect of the Rim101p-dependent alkaline pH response is to adapt to iron starvation conditions.	Iron	166-170	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	112-119
10582343-5	1999	IRP binding is under tight control so that it responds to changes in intracellular iron requirements in a coordinate manner by differentially regulating ferritin mRNA translational efficiency and TfR mRNA stability.	Iron	83-87	Wnt family member 2	Homo sapiens	0-3
15464654-2	2004	The identification of HFE and other genes involved in iron metabolism has greatly expanded our understanding of hereditary hemochromatosis.	Iron	54-58	homeostatic iron regulator	Homo sapiens	22-25
10582343-5	1999	IRP binding is under tight control so that it responds to changes in intracellular iron requirements in a coordinate manner by differentially regulating ferritin mRNA translational efficiency and TfR mRNA stability.	Iron	83-87	transferrin receptor	Homo sapiens	196-199
10582344-7	1999	Subsequent translation of the ALAS2 mRNA is dependent on an adequate iron supply.	Iron	69-73	5'-aminolevulinate synthase 2	Homo sapiens	30-35
10504726-3	1999	For protection, especially in conditions of trauma, inflammation and hemolysis, and to maintain iron homeostasis, a high-affinity binding protein, hemopexin, is required.	Iron	96-100	hemopexin	Homo sapiens	147-156
15464655-0	2004	Iron, the HFE gene, and hepatitis C. Intrahepatic iron overload is commonly seen in chronic hepatitis C infection.	Iron	50-54	homeostatic iron regulator	Homo sapiens	10-13
15464655-3	2004	In patients suffering from chronic hepatitis C, the presence of heterozygous HFE mutations associates with higher hepatic iron scores and advanced stages of fibrosis.	Iron	122-126	homeostatic iron regulator	Homo sapiens	77-80
15603661-7	2004	CONCLUSIONS: Iron absorption is decreased in some patients with hemochromatosis and HFE C282Y homozygosity after bariatric surgery, but their risk of developing iron deficiency may be diminished.	Iron	13-17	homeostatic iron regulator	Homo sapiens	84-87
10477281-0	1999	Iron-dependent regulation of transferrin receptor expression in Trypanosoma brucei.	Iron	0-4	transferrin receptor	Homo sapiens	29-49
10477281-2	1999	Here we show that expression of the trypanosomal transferrin receptor, which bears no structural similarity with mammalian transferrin receptors, is regulated by iron availability.	Iron	162-166	transferrin receptor	Homo sapiens	49-69
10477281-3	1999	Iron depletion of bloodstream forms of Trypanosoma brucei with the iron chelator deferoxamine resulted in a 3-fold up-regulation of the transferrin receptor and a 3-fold increase of the transferrin uptake rate.	Iron	0-4	transferrin receptor	Homo sapiens	136-156
10477281-3	1999	Iron depletion of bloodstream forms of Trypanosoma brucei with the iron chelator deferoxamine resulted in a 3-fold up-regulation of the transferrin receptor and a 3-fold increase of the transferrin uptake rate.	Iron	67-71	transferrin receptor	Homo sapiens	136-156
10477281-7	1999	Iron regulation of the transferrin receptor was found to be unaffected in Deltaaco::NEO/Deltaaco::HYG null mutants generated by targeted disruption of the TbACO gene.	Iron	0-4	transferrin receptor	Homo sapiens	23-43
10477281-10	1999	Due to varying binding affinities of the trypanosomal transferrin receptor for transferrins of different species, serum change can result in iron starvation.	Iron	141-145	transferrin receptor	Homo sapiens	54-74
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	49-53	Wnt family member 2	Homo sapiens	250-253
10520410-4	1999	Classically, four major proteins are involved in iron metabolism: (a) transferrin which is implicated in its plasmatic transport, (b) transferrin receptor which regulates iron-transferrin uptake, (c) ferritin, the major iron storage protein, and (d) IRP (Iron Regulatory Protein) which regulates both the entry and storage of iron by linking to the IRE (Iron Responsive Element), a nucleotidic sequence found on transferrin receptor and ferritin mRNA.	Iron	49-53	Wnt family member 2	Homo sapiens	255-278
15530368-0	2004	Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites.	Iron	73-77	frataxin	Homo sapiens	36-44
10520410-5	1999	Thus, IRP adapts gene expression to the iron cellular status.	Iron	40-44	Wnt family member 2	Homo sapiens	6-9
10520410-6	1999	Recent data give informations about new proteins involved in iron metabolism: HFE whose gene is mutated in genetic hemochromatosis, ceruloplasmin which permits cellular iron egress and frataxin which is implicated in the exit of iron from mitochondria.	Iron	61-65	homeostatic iron regulator	Homo sapiens	78-81
10520410-6	1999	Recent data give informations about new proteins involved in iron metabolism: HFE whose gene is mutated in genetic hemochromatosis, ceruloplasmin which permits cellular iron egress and frataxin which is implicated in the exit of iron from mitochondria.	Iron	61-65	frataxin	Homo sapiens	185-193
15530368-0	2004	Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites.	Iron	73-77	frataxin	Homo sapiens	55-59
10468869-0	1999	Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis.	Iron	59-63	transferrin receptor	Homo sapiens	8-28
15530368-1	2004	CyaY is the bacterial ortholog of frataxin, a small mitochondrial iron binding protein thought to be involved in iron sulphur cluster formation.	Iron	66-70	frataxin	Homo sapiens	0-4
10468869-2	1999	We investigated whether the soluble transferrin receptor (TfR) level was related to the degree of iron overload in 20 patients with thalassaemia intermedia, six patients with congenital dyserythropoietic anaemia type II (CDA II) and four patients with X-linked congenital sideroblastic anaemia (XLSA).	Iron	98-102	transferrin receptor	Homo sapiens	36-56
10468869-2	1999	We investigated whether the soluble transferrin receptor (TfR) level was related to the degree of iron overload in 20 patients with thalassaemia intermedia, six patients with congenital dyserythropoietic anaemia type II (CDA II) and four patients with X-linked congenital sideroblastic anaemia (XLSA).	Iron	98-102	transferrin receptor	Homo sapiens	58-61
15530368-1	2004	CyaY is the bacterial ortholog of frataxin, a small mitochondrial iron binding protein thought to be involved in iron sulphur cluster formation.	Iron	66-70	frataxin	Homo sapiens	34-42
15530368-1	2004	CyaY is the bacterial ortholog of frataxin, a small mitochondrial iron binding protein thought to be involved in iron sulphur cluster formation.	Iron	113-117	frataxin	Homo sapiens	0-4
15530368-1	2004	CyaY is the bacterial ortholog of frataxin, a small mitochondrial iron binding protein thought to be involved in iron sulphur cluster formation.	Iron	113-117	frataxin	Homo sapiens	34-42
15530368-3	2004	We have solved the solution structure of CyaY and used the structural information to map iron binding onto the protein surface.	Iron	89-93	frataxin	Homo sapiens	41-45
10477452-1	1999	BACKGROUND AND OBJECTIVE: Hemochromatosis is a genetic form of iron overload due to a defective HFE gene.	Iron	63-67	homeostatic iron regulator	Homo sapiens	96-99
15530368-5	2004	This function is conserved across species since the corresponding region of human frataxin is also able to bind iron, albeit with weaker affinity.	Iron	112-116	frataxin	Homo sapiens	82-90
16042119-2	2004	The result shows that the Fenton system with a dihydroxybenzoic acid (DHBA) chelator-mediator effectively reduced the color of a diluted solution of Carta Yellow RW liquid, Carta Yellow G liquid, and Cartasol Red 2GF liquid dye to a colorless level after 90 minutes of treatment with 100 microM iron II (Fe[II]), 100 microM DHBA, and 10 mM hydrogen peroxide (H2O2) at room temperature.	Iron	26-28	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	209-214
10488699-0	1999	Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis.	Iron	34-38	homeostatic iron regulator	Homo sapiens	81-84
15483690-0	2004	Quantum chemical studies of dioxygen activation by mononuclear non-heme iron enzymes with the 2-His-1-carboxylate facial triad.	Iron	72-76	viral integration site 1	Homo sapiens	96-101
10446187-2	1999	The tight relationship between oxygen and iron prompted us to investigate whether the expression of transferrin receptor (TfR), which mediates cellular iron uptake, is regulated by hypoxia.	Iron	152-156	transferrin receptor	Homo sapiens	100-120
10446187-2	1999	The tight relationship between oxygen and iron prompted us to investigate whether the expression of transferrin receptor (TfR), which mediates cellular iron uptake, is regulated by hypoxia.	Iron	152-156	transferrin receptor	Homo sapiens	122-125
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	0-4	transferrin receptor	Homo sapiens	91-96
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	42-46	transferrin receptor	Homo sapiens	67-89
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	42-46	transferrin receptor	Homo sapiens	91-96
15178542-8	2004	Fetal iron status, as indexed by cord serum ferritin concentration, was inversely related to placental IRP-1 (r = -0.66, P &lt; 0.001) and IRP-2 (r = -0.42, P = 0.05) activities.	Iron	6-10	aconitase 1	Homo sapiens	103-108
10434022-5	1999	This study examines the influence of the presence of traces of iron or copper ions during gamma-irradiation of plasmid DNA in water, on the possible formation of mutational hot spots in the lacI gene.	Iron	63-67	tissue factor pathway inhibitor	Homo sapiens	190-194
10441122-5	1999	The design of pdUppA-3"-p was based on the crystal structure of RNase A complexed with 5"-diphosphoadenosine 3"-phosphate (ppA-3"-p) [Leonidas, D. D., Shapiro, R., Irons, L. I., Russo, N., and Acharya, K. R. (1997) Biochemistry 36, 5578-5588].	Iron	164-169	ribonuclease A family member 1, pancreatic	Homo sapiens	64-71
15351367-0	2004	Iron supplementation brings up a lacking P300 in iron deficient children.	Iron	0-4	E1A binding protein p300	Homo sapiens	41-45
10419470-1	1999	Iron regulatory protein 1 (IRP1) regulates the synthesis of proteins involved in iron homeostasis by binding to iron-responsive elements (IREs) of messenger RNA.	Iron	81-85	aconitase 1	Homo sapiens	0-25
10419470-1	1999	Iron regulatory protein 1 (IRP1) regulates the synthesis of proteins involved in iron homeostasis by binding to iron-responsive elements (IREs) of messenger RNA.	Iron	81-85	aconitase 1	Homo sapiens	27-31
15351367-9	2004	After iron supplementation, P300 clearly became evident although its Pz amplitude remained smaller compared to C children.	Iron	6-10	E1A binding protein p300	Homo sapiens	28-32
10419470-1	1999	Iron regulatory protein 1 (IRP1) regulates the synthesis of proteins involved in iron homeostasis by binding to iron-responsive elements (IREs) of messenger RNA.	Iron	112-116	aconitase 1	Homo sapiens	0-25
15351367-11	2004	Iron supplementation nearly brings the P300 to normal levels although it is not known if the P300 difference in Pz is due to other nutritional/environmental deficits or to developmental psychomotor impairments in ID children.	Iron	0-4	E1A binding protein p300	Homo sapiens	39-43
10419470-1	1999	Iron regulatory protein 1 (IRP1) regulates the synthesis of proteins involved in iron homeostasis by binding to iron-responsive elements (IREs) of messenger RNA.	Iron	112-116	aconitase 1	Homo sapiens	27-31
15351367-13	2004	In this work an attention deficit is demonstrated in ID children through a severely reduced P300, which recovers substantially after iron supplementation.	Iron	133-137	E1A binding protein p300	Homo sapiens	92-96
15336316-7	2004	The effect of ferrous iron and transferrin was reversed by monoclonal antibody RVS10 against the transferrin receptor (TfR), which competes with transferrin for binding to TfR.	Iron	22-26	transferrin receptor	Homo sapiens	97-117
10383894-3	1999	The HFE wild-type gene product complexes with the transferrin receptor (TF) and two different HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of TFR for TF and increase cellular iron uptake.	Iron	210-214	homeostatic iron regulator	Homo sapiens	94-97
15336316-7	2004	The effect of ferrous iron and transferrin was reversed by monoclonal antibody RVS10 against the transferrin receptor (TfR), which competes with transferrin for binding to TfR.	Iron	22-26	transferrin receptor	Homo sapiens	119-122
10383894-3	1999	The HFE wild-type gene product complexes with the transferrin receptor (TF) and two different HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of TFR for TF and increase cellular iron uptake.	Iron	210-214	transferrin receptor	Homo sapiens	177-180
15336316-7	2004	The effect of ferrous iron and transferrin was reversed by monoclonal antibody RVS10 against the transferrin receptor (TfR), which competes with transferrin for binding to TfR.	Iron	22-26	transferrin receptor	Homo sapiens	172-175
15480846-10	2004	Both Fe(2+) and Fe(3+) reverse the MAO-A and B inhibition induced by the latter chelators, but not those initiated by 21-amino steroids.	Iron	5-7	monoamine oxidase A	Rattus norvegicus	35-40
10440210-10	1999	CONCLUSION: The combined findings of this study were that, in the dietary iron-loaded rat model, increased iron stores were localized to periportal hepatocytes and that these same hepatocytes also had increased ferritin, transferrin receptor and transferrin protein expression.	Iron	74-78	transferrin receptor	Rattus norvegicus	221-241
15480846-10	2004	Both Fe(2+) and Fe(3+) reverse the MAO-A and B inhibition induced by the latter chelators, but not those initiated by 21-amino steroids.	Iron	16-18	monoamine oxidase A	Rattus norvegicus	35-40
10440210-10	1999	CONCLUSION: The combined findings of this study were that, in the dietary iron-loaded rat model, increased iron stores were localized to periportal hepatocytes and that these same hepatocytes also had increased ferritin, transferrin receptor and transferrin protein expression.	Iron	107-111	transferrin receptor	Rattus norvegicus	221-241
15480846-11	2004	The data infer that either the inhibition of MAO by 21-amino steroids is either the resultant of their conversion to an irreversible covalently bound ligand or that the iron chelation moiety and MAO inhibitory activity in these compounds are not mutually shared.	Iron	169-173	monoamine oxidase A	Rattus norvegicus	45-48
15543932-1	2004	Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR) through iron-regulatory mRNA-binding proteins (IRPs), and may additionally regulate uptake and accumulation of non-transferrin-bound iron (NTBI).	Iron	0-4	transferrin receptor	Homo sapiens	126-146
10405747-1	1999	PURPOSE: To determine whether the frequency of hepatocellular carcinoma (HCC) in patients with cirrhosis is affected by hepatic iron deposition as detected with magnetic resonance (MR) imaging.	Iron	128-132	HCC	Homo sapiens	73-76
10405747-6	1999	The frequency of HCC in patients with iron deposition in regenerative nodules (52% [37 of 71 patients]) was significantly higher (P = .015) than that in patients without iron in regenerative nodules (34% [43 of 125 patients]).	Iron	38-42	HCC	Homo sapiens	17-20
10405747-7	1999	CONCLUSION: The occurrence of HCC may be associated causally with iron deposition in regenerative nodules in patients with cirrhosis.	Iron	66-70	HCC	Homo sapiens	30-33
15543932-1	2004	Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR) through iron-regulatory mRNA-binding proteins (IRPs), and may additionally regulate uptake and accumulation of non-transferrin-bound iron (NTBI).	Iron	0-4	transferrin receptor	Homo sapiens	148-151
10405747-8	1999	MR imaging can enable detection of iron deposition in regenerative nodules as a possible risk factor for the development of HCC.	Iron	35-39	HCC	Homo sapiens	124-127
15543932-1	2004	Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR) through iron-regulatory mRNA-binding proteins (IRPs), and may additionally regulate uptake and accumulation of non-transferrin-bound iron (NTBI).	Iron	42-46	transferrin receptor	Homo sapiens	126-146
15543932-1	2004	Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR) through iron-regulatory mRNA-binding proteins (IRPs), and may additionally regulate uptake and accumulation of non-transferrin-bound iron (NTBI).	Iron	42-46	transferrin receptor	Homo sapiens	148-151
10369785-2	1999	HFE binds tightly to transferrin receptor (TfR), the receptor that mediates uptake of iron-loaded transferrin.	Iron	86-90	homeostatic iron regulator	Homo sapiens	0-3
15543932-1	2004	Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR) through iron-regulatory mRNA-binding proteins (IRPs), and may additionally regulate uptake and accumulation of non-transferrin-bound iron (NTBI).	Iron	161-165	transferrin receptor	Homo sapiens	126-146
10369785-2	1999	HFE binds tightly to transferrin receptor (TfR), the receptor that mediates uptake of iron-loaded transferrin.	Iron	86-90	transferrin receptor	Homo sapiens	21-41
10369785-2	1999	HFE binds tightly to transferrin receptor (TfR), the receptor that mediates uptake of iron-loaded transferrin.	Iron	86-90	transferrin receptor	Homo sapiens	43-46
15365174-0	2004	Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.	Iron	66-70	hephaestin	Mus musculus	32-42
10388628-2	1999	Similar to the mammalian heme oxygenase, it binds hemin stoichiometrically and catalyzes the oxygen-dependent conversion of hemin to biliverdin, carbon monoxide, and free iron.	Iron	171-175	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	25-39
15365174-4	2004	Mice deficient in both Cp and Heph, but not each individually, had a striking, age-dependent increase in retinal pigment epithelium and retinal iron.	Iron	144-148	hephaestin	Mus musculus	30-34
10359845-0	1999	Map-based cloning of chloronerva, a gene involved in iron uptake of higher plants encoding nicotianamine synthase.	Iron	53-57	nicotianamine synthase	Solanum lycopersicum	21-32
15365174-7	2004	This pathology indicates that Cp and Heph are critical for CNS iron homeostasis and that loss of Cp and Heph in the mouse leads to age-dependent retinal neurodegeneration, providing a model that can be used to test the therapeutic efficacy of iron chelators and antiangiogenic agents.	Iron	63-67	hephaestin	Mus musculus	37-41
10359845-2	1999	In tomato, the mutant chloronerva exhibits constitutive expression of iron uptake responses and intercostal chlorosis.	Iron	70-74	nicotianamine synthase	Solanum lycopersicum	22-33
10359845-3	1999	Biochemically, chloronerva is an auxotroph for nicotianamine, a key polyamine in plant iron uptake metabolism.	Iron	87-91	nicotianamine synthase	Solanum lycopersicum	15-26
15302586-2	2004	Here, we investigated the role of the Rho family small GTPases Rac1 and Cdc42 in Fes-mediated neuritogenesis, which have been implicated in neuronal differentiation in other systems.	Iron	81-84	Rac family small GTPase 1	Rattus norvegicus	63-67
10353251-8	1999	In cells exposed to iron chelation or cobaltous ions, HIF-1 is dissociated from pVHL.	Iron	20-24	von Hippel-Lindau tumor suppressor	Homo sapiens	80-84
10353251-9	1999	These findings indicate that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF alpha-subunits.	Iron	71-75	von Hippel-Lindau tumor suppressor	Homo sapiens	63-67
15302586-2	2004	Here, we investigated the role of the Rho family small GTPases Rac1 and Cdc42 in Fes-mediated neuritogenesis, which have been implicated in neuronal differentiation in other systems.	Iron	81-84	cell division cycle 42	Rattus norvegicus	72-77
15302586-3	2004	Fes-induced acceleration of neurite outgrowth in response to NGF treatment was completely blocked by the expression of dominant-negative Rac1 or Cdc42.	Iron	0-3	Rac family small GTPase 1	Rattus norvegicus	137-141
15302586-3	2004	Fes-induced acceleration of neurite outgrowth in response to NGF treatment was completely blocked by the expression of dominant-negative Rac1 or Cdc42.	Iron	0-3	cell division cycle 42	Rattus norvegicus	145-150
10196363-3	1999	This gene, ABC7, is an ortholog of the yeast ATM1 gene whose product localizes to the mitochondrial inner membrane and is involved in iron homeostasis.	Iron	134-138	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	45-49
15302586-4	2004	Expression of a kinase-active mutant of Fes induced constitutive relocalization of endogenous Rac1 to the cell periphery in the absence of NGF, and led to dramatic actin reorganization and spontaneous neurite extension.	Iron	40-43	Rac family small GTPase 1	Rattus norvegicus	94-98
15315790-3	2004	We report that beta2m-deficient mice, like Hfe-/- mice, lack the adaptive hepatic hepcidin mRNA increase to iron overload.	Iron	108-112	beta-2 microglobulin	Mus musculus	15-21
15315790-4	2004	The inverse correlation of hepatic iron levels and hepcidin mRNA expression in six beta2m-/- mice underlines the importance of hepcidin in regulating body iron stores.	Iron	35-39	beta-2 microglobulin	Mus musculus	83-89
10233755-4	1999	Nramp2 encodes a divalent cation transporter and is the carrier of a defect in models of microcytic anaemia, associated with impaired intestinal iron uptake.	Iron	145-149	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-6
15315790-6	2004	This result implicates a broader role of beta2m in mammalian iron metabolism, suggesting that (an) additional beta2m-interacting protein(s) could be involved in controlling iron homeostasis, and highlighting the emerging connection of iron metabolism with the immune system.	Iron	61-65	beta-2 microglobulin	Mus musculus	41-47
10085150-0	1999	The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.	Iron	89-93	homeostatic iron regulator	Homo sapiens	40-43
10085150-15	1999	Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments.	Iron	57-61	homeostatic iron regulator	Homo sapiens	11-14
15315790-6	2004	This result implicates a broader role of beta2m in mammalian iron metabolism, suggesting that (an) additional beta2m-interacting protein(s) could be involved in controlling iron homeostasis, and highlighting the emerging connection of iron metabolism with the immune system.	Iron	173-177	beta-2 microglobulin	Mus musculus	110-116
10085150-16	1999	HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered.	Iron	25-29	homeostatic iron regulator	Homo sapiens	0-3
15315790-6	2004	This result implicates a broader role of beta2m in mammalian iron metabolism, suggesting that (an) additional beta2m-interacting protein(s) could be involved in controlling iron homeostasis, and highlighting the emerging connection of iron metabolism with the immune system.	Iron	173-177	beta-2 microglobulin	Mus musculus	110-116
10085150-17	1999	These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake.	Iron	157-161	homeostatic iron regulator	Homo sapiens	121-124
15339999-2	2004	This study focuses on the effects of IVAA supplementation on serum concentrations of soluble transferrin receptors (TfR) on the basis of the hypothesis that an increase of labile iron in the cytosol will lead to inhibition of TfR expression.	Iron	179-183	transferrin receptor	Homo sapiens	93-114
10037708-1	1999	Iron regulatory protein-1 (IRP-1) controls the expression of several mRNAs by binding to iron-responsive elements (IREs) in their untranslated regions.	Iron	89-93	aconitase 1	Homo sapiens	0-25
10037708-1	1999	Iron regulatory protein-1 (IRP-1) controls the expression of several mRNAs by binding to iron-responsive elements (IREs) in their untranslated regions.	Iron	89-93	aconitase 1	Homo sapiens	27-32
10037708-2	1999	In iron-replete cells, a 4Fe-4S cluster converts IRP-1 to cytoplasmic aconitase.	Iron	3-7	aconitase 1	Homo sapiens	49-54
10037708-7	1999	Surprisingly, a remarkable loss of both IRE binding and aconitase activities of IRP-1 follows treatment with MSB for 1-2 h. These effects do not result from alterations in IRP-1 half-life, can be antagonized by the antioxidant N-acetylcysteine, and regulate IRE-containing mRNAs; the capacity of iron-starved MSB-treated cells to increase transferrin receptor mRNA levels is inhibited, and MSB increases the translation of a human growth hormone indicator mRNA bearing an IRE in its 5"-untranslated region.	Iron	296-300	aconitase 1	Homo sapiens	80-85
10037708-9	1999	Thus, menadione-induced oxidative stress leads to post-translational inactivation of both genetic and enzymatic functions of IRP-1 by a mechanism that lies beyond the "classical" Fe-S cluster switch and exerts multiple effects on cellular iron metabolism.	Iron	179-181	aconitase 1	Homo sapiens	125-130
10037708-9	1999	Thus, menadione-induced oxidative stress leads to post-translational inactivation of both genetic and enzymatic functions of IRP-1 by a mechanism that lies beyond the "classical" Fe-S cluster switch and exerts multiple effects on cellular iron metabolism.	Iron	239-243	aconitase 1	Homo sapiens	125-130
15339999-2	2004	This study focuses on the effects of IVAA supplementation on serum concentrations of soluble transferrin receptors (TfR) on the basis of the hypothesis that an increase of labile iron in the cytosol will lead to inhibition of TfR expression.	Iron	179-183	transferrin receptor	Homo sapiens	116-119
10024528-14	1999	In addition, the well-characterized Fe3+-chelate reduction capabilities of NFR, in addition to known Fe3+-haemoglobin reduction roles for mammal b5R isoforms, suggest further and more generalized roles for the b5R class in endocellular iron reduction.	Iron	236-240	cytochrome b5 reductase 3	Homo sapiens	210-213
15339999-2	2004	This study focuses on the effects of IVAA supplementation on serum concentrations of soluble transferrin receptors (TfR) on the basis of the hypothesis that an increase of labile iron in the cytosol will lead to inhibition of TfR expression.	Iron	179-183	transferrin receptor	Homo sapiens	226-229
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	34-38	ferroxidase FET3	Saccharomyces cerevisiae S288C	216-220
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	56-60	ferroxidase FET3	Saccharomyces cerevisiae S288C	216-220
15449310-10	2004	The roles of OGG1 and NTG2 genes in the repair of lethal and mutagenic oxidative lesions induced by H2O2 and their relationships with iron and copper ions are discussed.	Iron	134-138	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	22-26
15266614-2	2004	We hypothesized that increased levels of serum bilirubin may play a protective role against oxidative stress induced by iron overload in carriers of mutations in the hereditary hemochromatosis gene (HFE).	Iron	120-124	homeostatic iron regulator	Homo sapiens	199-202
15247188-10	2004	Finally, HFE appears to play a minor role in the regulation of iron absorption by the duodenal enterocyte.	Iron	63-67	homeostatic iron regulator	Homo sapiens	9-12
15107423-7	2004	By contrast, increasing the mitochondrial iron content of sod1Delta yeast using high copy MMT1, which encodes a mitochondrial iron transporter, was sufficient to mimic the seo mutants.	Iron	42-46	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	58-62
15107423-7	2004	By contrast, increasing the mitochondrial iron content of sod1Delta yeast using high copy MMT1, which encodes a mitochondrial iron transporter, was sufficient to mimic the seo mutants.	Iron	42-46	Mmt1p	Saccharomyces cerevisiae S288C	90-94
15133041-0	2004	Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae.	Iron	86-90	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	16-20
15123701-1	2004	Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the iron regulon, including the high affinity cell-surface transport system encoded by FET3 and FTR1.	Iron	37-41	ferroxidase FET3	Saccharomyces cerevisiae S288C	171-175
15123701-1	2004	Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the iron regulon, including the high affinity cell-surface transport system encoded by FET3 and FTR1.	Iron	88-92	ferroxidase FET3	Saccharomyces cerevisiae S288C	171-175
15271355-2	2004	A pvdD mutant did not synthesize pyoverdine and lacked a high Mr iron-regulated cytoplasmic protein (IRCP).	Iron	65-69	pyoverdine synthetase D	Pseudomonas aeruginosa PAO1	2-6
15182337-0	2004	Prevalence of HFE mutations among the Thai population and correlation with iron loading in haemoglobin E disorder.	Iron	75-79	homeostatic iron regulator	Homo sapiens	14-17
15182337-1	2004	Co-inheritance of HFE mutations has a substantial role in iron overload in beta-thalassaemia carriers in north European populations where two HFE mutations, C282Y and H63D, are prevalent.	Iron	58-62	homeostatic iron regulator	Homo sapiens	18-21
15162488-1	2004	Neuroglobin, a recently discovered globin predominantly expressed in neuronal tissue of vertebrates, binds small, gaseous ligands at the sixth coordination position of the heme iron.	Iron	177-181	neuroglobin	Mus musculus	0-11
15196016-4	2004	Rnr4 is unique in that it lacks three iron-binding residues conserved in all other R2s.	Iron	38-42	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	0-4
15172111-0	2004	Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis.	Iron	31-35	ceruloplasmin	Rattus norvegicus	88-101
15172111-3	2004	The iron exporter ferroportin-1 (FP) and the multicopper oxidase ceruloplasmin (CP) are essential for iron efflux from cells.	Iron	4-8	ceruloplasmin	Rattus norvegicus	80-82
15172111-3	2004	The iron exporter ferroportin-1 (FP) and the multicopper oxidase ceruloplasmin (CP) are essential for iron efflux from cells.	Iron	102-106	ceruloplasmin	Rattus norvegicus	80-82
15215598-4	2004	The effectiveness of phosvitin was related to the iron concentration, indicating that phosvitin acts as an antioxidant by chelating iron ions.	Iron	50-54	casein kinase 2 beta	Homo sapiens	86-95
15215598-4	2004	The effectiveness of phosvitin was related to the iron concentration, indicating that phosvitin acts as an antioxidant by chelating iron ions.	Iron	132-136	casein kinase 2 beta	Homo sapiens	21-30
15215598-4	2004	The effectiveness of phosvitin was related to the iron concentration, indicating that phosvitin acts as an antioxidant by chelating iron ions.	Iron	132-136	casein kinase 2 beta	Homo sapiens	86-95
15155653-1	2004	Neisseria meningitidis acquires iron through the action of the transferrin (Tf) receptor, which is composed of the Tf-binding proteins A and B (TbpA and TbpB).	Iron	32-36	transferrin receptor	Homo sapiens	63-88
15235875-0	2004	A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan.	Iron	79-83	glutamic--pyruvic transaminase	Homo sapiens	33-57
15235875-3	2004	This study aimed to test whether iron removal by repeated phlebotomy improves serum alanine aminotransferase (ALT) levels in patients with CHC.	Iron	33-37	glutamic--pyruvic transaminase	Homo sapiens	84-108
15139022-2	2004	To characterize better the potential mechanisms for iron transport into and within the brain, we have analyzed expression patterns of two factors: divalent metal transporter 1 (DMT1) and stimulator of Fe transport (SFT).	Iron	52-56	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	147-175
15139022-2	2004	To characterize better the potential mechanisms for iron transport into and within the brain, we have analyzed expression patterns of two factors: divalent metal transporter 1 (DMT1) and stimulator of Fe transport (SFT).	Iron	52-56	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	177-181
15139022-3	2004	DMT1 is known to participate in brain iron uptake although functional information is lacking.	Iron	38-42	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
15139022-5	2004	Like DMT1, SFT function has been implicated in transferrin and nontransferrin-bound iron uptake.	Iron	84-88	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	5-9
15139022-10	2004	The significantly elevated levels of SFT/UbcH5A mRNA in the neonatal mouse and its localization to choroid plexus, a major site of brain iron acquisition, suggest that this factor may contribute to the rapid rate of brain iron uptake that occurs in the early postnatal period.	Iron	137-141	ubiquitin conjugating enzyme E2 D1	Homo sapiens	41-47
15139022-10	2004	The significantly elevated levels of SFT/UbcH5A mRNA in the neonatal mouse and its localization to choroid plexus, a major site of brain iron acquisition, suggest that this factor may contribute to the rapid rate of brain iron uptake that occurs in the early postnatal period.	Iron	222-226	ubiquitin conjugating enzyme E2 D1	Homo sapiens	41-47
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	106-110	transferrin receptor	Mus musculus	59-80
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	106-110	transferrin receptor	Mus musculus	82-85
15173932-7	2004	This was paralleled by reduced amounts of DMT-1 and FP-1 in the duodenum while the expression of DMT-1, FP-1, and hepcidin in the liver were increased with dietary iron overload.	Iron	164-168	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	97-102
15154810-5	2004	The metals are eta(6)-coordinated to the puckered six-membered face of the tricarbadecaboranyl cage, with the exopolyhedral substituents bonded to the low-coordinate carbon adjacent to the iron.	Iron	189-193	endothelin receptor type A	Homo sapiens	5-8
14751926-1	2004	Hephaestin (Hp) plays an important role in intestinal iron absorption and is predicted to be a ferroxidase based on significant sequence identity to the serum multicopper ferroxidase ceruloplasmin.	Iron	54-58	hephaestin	Mus musculus	0-10
10029606-0	1999	Four new mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causing X-linked sideroblastic anemia: increased pyridoxine responsiveness after removal of iron overload by phlebotomy and coinheritance of hereditary hemochromatosis.	Iron	177-181	5'-aminolevulinate synthase 2	Homo sapiens	73-78
14751926-6	2004	We suggest that hephaestin, by way of its ferroxidase activity, facilitates iron export from intestinal enterocytes, most likely in cooperation with the basolateral iron transporter, Ireg1.	Iron	76-80	hephaestin	Mus musculus	16-26
10095770-3	1999	Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocytes, and whether the modulation is compatible with the hypothesis that IRPs, in turn, may regulate the expression of iron transport proteins in maturating enterocytes during migration to the villus tips.	Iron	19-23	aconitase 1	Rattus norvegicus	110-115
10095770-3	1999	Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocytes, and whether the modulation is compatible with the hypothesis that IRPs, in turn, may regulate the expression of iron transport proteins in maturating enterocytes during migration to the villus tips.	Iron	84-88	aconitase 1	Rattus norvegicus	110-115
15140607-5	2004	Transferrin receptor expression was increased with iron chelation demonstrating that a global decrease in protein synthesis could not account for the Thy1 changes.	Iron	51-55	transferrin receptor	Rattus norvegicus	0-20
10095770-3	1999	Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocytes, and whether the modulation is compatible with the hypothesis that IRPs, in turn, may regulate the expression of iron transport proteins in maturating enterocytes during migration to the villus tips.	Iron	84-88	aconitase 1	Rattus norvegicus	110-115
10095770-7	1999	Accordingly, the activity of IRP-1 decreased at this site 12 h after parenteral iron administration, but remained high at the villus tips.	Iron	80-84	aconitase 1	Rattus norvegicus	29-34
15104997-14	2004	CONCLUSIONS: TfR could be useful in evaluating intracellular iron status in children.	Iron	61-65	transferrin receptor	Homo sapiens	13-16
10095770-10	1999	IRP-2 activity remained significantly higher at duodenal villus tips than in crypts, even after 72 h. Intestinal iron absorption capacity decreased with the same delay as IRP-1 activity after intravenous iron administration.	Iron	204-208	aconitase 1	Rattus norvegicus	171-176
10095770-12	1999	Luminal administration of iron decreased duodenal IRP-1 and IRP-2 activity at tips and crypts within 2 h. Thus, recently absorbed iron becomes available to cytosolic IRP during its passage through the enterocyte.	Iron	26-30	aconitase 1	Rattus norvegicus	50-55
10095770-12	1999	Luminal administration of iron decreased duodenal IRP-1 and IRP-2 activity at tips and crypts within 2 h. Thus, recently absorbed iron becomes available to cytosolic IRP during its passage through the enterocyte.	Iron	26-30	caspase 3	Rattus norvegicus	50-53
10095770-12	1999	Luminal administration of iron decreased duodenal IRP-1 and IRP-2 activity at tips and crypts within 2 h. Thus, recently absorbed iron becomes available to cytosolic IRP during its passage through the enterocyte.	Iron	130-134	aconitase 1	Rattus norvegicus	50-55
10095770-12	1999	Luminal administration of iron decreased duodenal IRP-1 and IRP-2 activity at tips and crypts within 2 h. Thus, recently absorbed iron becomes available to cytosolic IRP during its passage through the enterocyte.	Iron	130-134	caspase 3	Rattus norvegicus	50-53
15099342-2	2004	Hemochromatosis is a common preventable iron overload disease, due in over 90% of cases to C282Y homozygosity in the HFE gene.	Iron	40-44	homeostatic iron regulator	Homo sapiens	117-120
10095776-4	1999	Like other insect transferrins, Drosophila transferrin appears to have a functional iron-binding site only in the N-terminal lobe.	Iron	84-88	Transferrin 1	Drosophila melanogaster	18-29
10095776-8	1999	Iron supplementation of the diet resulted in lower levels of transferrin mRNA.	Iron	0-4	Transferrin 1	Drosophila melanogaster	61-72
10189391-8	1999	The recent identification of genetic mutations of the hemochromatosis gene (HFE) in the majority of patients with PCT confirms previous hypotheses on the association between PCT and hemochromatosis, allows a step forward in the understanding of the pathophysiology of the disturbance of iron metabolism in the liver of PCT patients, and provides an easily detectable genetic marker which could have a useful clinical application.	Iron	287-291	homeostatic iron regulator	Homo sapiens	76-79
10189391-9	1999	Besides the epidemiological relevance of the association between PCT and hemochromatosis, however, it remains to be fully understood how iron overload, and in particular the cellular modifications of the iron status secondary to hemochromatosis mutations, affect the activity of URO-D, and how the altered iron metabolism interacts with the other two common triggers for PCT and etiological agents for the associated liver disease: alcohol and hepatitis viruses.	Iron	137-141	uroporphyrinogen decarboxylase	Homo sapiens	279-284
10189391-9	1999	Besides the epidemiological relevance of the association between PCT and hemochromatosis, however, it remains to be fully understood how iron overload, and in particular the cellular modifications of the iron status secondary to hemochromatosis mutations, affect the activity of URO-D, and how the altered iron metabolism interacts with the other two common triggers for PCT and etiological agents for the associated liver disease: alcohol and hepatitis viruses.	Iron	204-208	uroporphyrinogen decarboxylase	Homo sapiens	279-284
10189391-9	1999	Besides the epidemiological relevance of the association between PCT and hemochromatosis, however, it remains to be fully understood how iron overload, and in particular the cellular modifications of the iron status secondary to hemochromatosis mutations, affect the activity of URO-D, and how the altered iron metabolism interacts with the other two common triggers for PCT and etiological agents for the associated liver disease: alcohol and hepatitis viruses.	Iron	204-208	uroporphyrinogen decarboxylase	Homo sapiens	279-284
10189401-0	1999	HFE mutation analysis in patients with hepatitis C virus with positive screening for iron overload.	Iron	85-89	homeostatic iron regulator	Homo sapiens	0-3
10084280-5	1999	Cellular iron storage and uptake are coordinately regulated post-transcriptionally by cytoplasmic factors, iron-regulatory proteins 1 and 2 (IRP-1 and IRP-2).	Iron	9-13	aconitase 1	Homo sapiens	107-139
15059075-6	2004	As observed in HFE hemochromatosis, the beta-thalassemia trait seems to aggravate the clinical picture of patients lacking TFR2, favoring higher rates of iron accumulation probably by activation of the erythroid iron regulator.	Iron	212-216	homeostatic iron regulator	Homo sapiens	15-18
10084280-5	1999	Cellular iron storage and uptake are coordinately regulated post-transcriptionally by cytoplasmic factors, iron-regulatory proteins 1 and 2 (IRP-1 and IRP-2).	Iron	9-13	aconitase 1	Homo sapiens	141-146
10084280-6	1999	Under conditions of limited iron supply, IRP binding to iron-responsive elements (present in 5" untranslated region of ferritin mRNA and 3" untranslated region of transferrin receptor mRNA) blocks ferritin mRNA translation and stabilizes transferrin receptor mRNA.	Iron	28-32	Wnt family member 2	Homo sapiens	41-44
10084280-6	1999	Under conditions of limited iron supply, IRP binding to iron-responsive elements (present in 5" untranslated region of ferritin mRNA and 3" untranslated region of transferrin receptor mRNA) blocks ferritin mRNA translation and stabilizes transferrin receptor mRNA.	Iron	56-60	Wnt family member 2	Homo sapiens	41-44
9918923-1	1999	Nitric oxide (NO) donors S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside (SNP) modulate iron regulatory protein (IRP) activity and may, therefore, affect iron uptake through transferrin receptor expression.	Iron	104-108	Wnt family member 2	Homo sapiens	129-132
15121519-11	2004	These effects may be mediated by alterations in lead toxicokinetics via iron metabolic pathways regulated by the HFE gene product and body iron stores.	Iron	72-76	homeostatic iron regulator	Homo sapiens	113-116
9988272-0	1999	Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.	Iron	63-67	hephaestin	Mus musculus	0-10
14752097-0	2004	1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide.	Iron	112-116	transferrin receptor	Homo sapiens	91-111
9988272-9	1999	We suggest that the hephaestin protein is a multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals.	Iron	82-86	hephaestin	Mus musculus	20-30
9988272-9	1999	We suggest that the hephaestin protein is a multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals.	Iron	195-199	hephaestin	Mus musculus	20-30
14752097-0	2004	1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide.	Iron	112-116	nitric oxide synthase 1	Homo sapiens	164-194
14752097-4	2004	This, in turn, stimulated transferrin receptor (TfR)-dependent iron signaling via activation of the iron-regulatory protein/iron-responsive element interaction.	Iron	63-67	transferrin receptor	Homo sapiens	26-46
11601029-9	1999	TfR is a best parameter in determining iron deficiency in chronic diseases than SF and other iron parameters.	Iron	39-43	transferrin receptor	Homo sapiens	0-3
14752097-4	2004	This, in turn, stimulated transferrin receptor (TfR)-dependent iron signaling via activation of the iron-regulatory protein/iron-responsive element interaction.	Iron	63-67	transferrin receptor	Homo sapiens	48-51
14752097-4	2004	This, in turn, stimulated transferrin receptor (TfR)-dependent iron signaling via activation of the iron-regulatory protein/iron-responsive element interaction.	Iron	100-104	transferrin receptor	Homo sapiens	26-46
14752097-4	2004	This, in turn, stimulated transferrin receptor (TfR)-dependent iron signaling via activation of the iron-regulatory protein/iron-responsive element interaction.	Iron	100-104	transferrin receptor	Homo sapiens	48-51
10094372-2	1999	Cellular iron uptake is facilitated by transferrin receptor (TfR)-mediated endocytosis.	Iron	9-13	transferrin receptor	Homo sapiens	39-59
14752097-4	2004	This, in turn, stimulated transferrin receptor (TfR)-dependent iron signaling via activation of the iron-regulatory protein/iron-responsive element interaction.	Iron	100-104	transferrin receptor	Homo sapiens	26-46
10094372-2	1999	Cellular iron uptake is facilitated by transferrin receptor (TfR)-mediated endocytosis.	Iron	9-13	transferrin receptor	Homo sapiens	61-64
14752097-4	2004	This, in turn, stimulated transferrin receptor (TfR)-dependent iron signaling via activation of the iron-regulatory protein/iron-responsive element interaction.	Iron	100-104	transferrin receptor	Homo sapiens	48-51
10094372-4	1999	The synthesis of TfR and the iron storage protein ferritin is regulated reciprocally at the post-transcriptional level according to the cellular iron status.	Iron	145-149	transferrin receptor	Homo sapiens	17-20
10094372-6	1999	The serum TfR (sTfR) level is closely related to erythroid TfR turnover and the prime determinants of the sTfR concentration are cellular iron demands and erythroid proliferation rate.	Iron	138-142	transferrin receptor	Homo sapiens	10-13
14752097-8	2004	Pretreatment of cells with sepiapterin to promote BH(4) biosynthesis or cell-permeable iron chelator and TfR antibody to prevent iron-catalyzed BH(4) decomposition inhibited MPP(+) cytotoxicity.	Iron	129-133	transferrin receptor	Homo sapiens	105-108
14752097-9	2004	Preincubation of cerebellar granule neurons with nNOS inhibitor exacerbated MPP(+)-induced iron uptake, BH(4) depletion, proteasomal inactivation, and apoptosis.	Iron	91-95	nitric oxide synthase 1	Homo sapiens	49-53
9914507-1	1999	Iron regulatory proteins (IRP)-1 and 2 are cytoplasmic mRNA-binding proteins that control intracellular iron homeostasis by regulating the translation of ferritin mRNA and stability of transferrin receptor mRNA in an iron-dependent fashion.	Iron	104-108	aconitase 1	Rattus norvegicus	0-38
9914507-1	1999	Iron regulatory proteins (IRP)-1 and 2 are cytoplasmic mRNA-binding proteins that control intracellular iron homeostasis by regulating the translation of ferritin mRNA and stability of transferrin receptor mRNA in an iron-dependent fashion.	Iron	217-221	aconitase 1	Rattus norvegicus	0-38
15179052-0	2004	Iron enhances NGF-induced neurite outgrowth in PC12 cells.	Iron	0-4	nerve growth factor	Rattus norvegicus	14-17
15179052-4	2004	The addition of iron enhanced NGF-mediated cell adhesion, spreading and neurite outgrowth.	Iron	16-20	nerve growth factor	Rattus norvegicus	30-33
15179052-6	2004	In agreement with this, intracellular, but not extracellular, iron enhanced NGF-induced neurite outgrowth in pre-spread PC12 cells, and this was correlated with increased ERK activity.	Iron	62-66	nerve growth factor	Rattus norvegicus	76-79
15179052-7	2004	Taken together, these data suggest that intracellular iron promotes NGF-stimulated differentiation of PC12 cells by increasing ERK activity.	Iron	54-58	nerve growth factor	Rattus norvegicus	68-71
14720122-2	2004	At least six proteins (IscS, IscU, IscA, HscB, HscA and ferredoxin) have been identified as being essential for the biogenesis of iron-sulphur proteins in bacteria.	Iron	130-134	NFS1 cysteine desulfurase	Homo sapiens	23-27
14720122-3	2004	It has been shown that IscS is a cysteine desulphurase that provides sulphur for iron-sulphur clusters, and that IscU is a scaffold for the IscS-mediated assembly of iron-sulphur clusters.	Iron	81-85	NFS1 cysteine desulfurase	Homo sapiens	23-27
14720122-3	2004	It has been shown that IscS is a cysteine desulphurase that provides sulphur for iron-sulphur clusters, and that IscU is a scaffold for the IscS-mediated assembly of iron-sulphur clusters.	Iron	81-85	NFS1 cysteine desulfurase	Homo sapiens	140-144
14720122-3	2004	It has been shown that IscS is a cysteine desulphurase that provides sulphur for iron-sulphur clusters, and that IscU is a scaffold for the IscS-mediated assembly of iron-sulphur clusters.	Iron	166-170	NFS1 cysteine desulfurase	Homo sapiens	23-27
14720122-3	2004	It has been shown that IscS is a cysteine desulphurase that provides sulphur for iron-sulphur clusters, and that IscU is a scaffold for the IscS-mediated assembly of iron-sulphur clusters.	Iron	166-170	NFS1 cysteine desulfurase	Homo sapiens	140-144
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	29-33	NFS1 cysteine desulfurase	Homo sapiens	236-240
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	NFS1 cysteine desulfurase	Homo sapiens	236-240
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	NFS1 cysteine desulfurase	Homo sapiens	236-240
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	NFS1 cysteine desulfurase	Homo sapiens	236-240
14720122-5	2004	Here we show that IscA is an iron binding protein with an apparent iron association constant of 3.0x10(19) M(-1), and that iron-loaded IscA can provide iron for the assembly of transient iron-sulphur clusters in IscU in the presence of IscS and L-cysteine in vitro.	Iron	67-71	NFS1 cysteine desulfurase	Homo sapiens	236-240
15003939-7	2004	Higher doses of iron reduce iron regulatory protein-1 binding activity and are accompanied by a reduction in TfR mRNA.	Iron	16-20	transferrin receptor	Homo sapiens	109-112
15003939-8	2004	Thus, for A549 cells, different mechanisms influencing IRP-IRE interaction allow ferritin translation in the presence of TfR mRNA to provide for iron needs and yet prevent excessive iron uptake.	Iron	145-149	Wnt family member 2	Homo sapiens	55-58
15003939-8	2004	Thus, for A549 cells, different mechanisms influencing IRP-IRE interaction allow ferritin translation in the presence of TfR mRNA to provide for iron needs and yet prevent excessive iron uptake.	Iron	145-149	transferrin receptor	Homo sapiens	121-124
15003939-8	2004	Thus, for A549 cells, different mechanisms influencing IRP-IRE interaction allow ferritin translation in the presence of TfR mRNA to provide for iron needs and yet prevent excessive iron uptake.	Iron	182-186	Wnt family member 2	Homo sapiens	55-58
15003939-8	2004	Thus, for A549 cells, different mechanisms influencing IRP-IRE interaction allow ferritin translation in the presence of TfR mRNA to provide for iron needs and yet prevent excessive iron uptake.	Iron	182-186	transferrin receptor	Homo sapiens	121-124
15051895-9	2004	However, using soluble transferrin receptor (sTfR) levels, we were able to demonstrate an inverse linear relationship (r = 0.37, p = 0.021, n = 41) between Fe status and ceruloplasmin.	Iron	156-158	transferrin receptor	Homo sapiens	23-43
14762707-14	2004	On the other hand, the amino group in carbamoylphosphonic acid2 lowers the stability of the complexes with metals favoring oxygen ligands (Ca, Mg and Fe) and increases the selectivity towards Zn.	Iron	150-152	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	58-63
14694147-5	2004	XOR requires molybdopterin, iron-sulphur centres, and FAD as cofactors and has two interconvertible forms, xanthine oxidase and xanthine dehydrogenase, which transfer electrons from xanthine to oxygen and NAD(+), respectively, yielding superoxide, hydrogen peroxide and NADH.	Iron	28-32	xanthine dehydrogenase	Homo sapiens	0-3
14694147-5	2004	XOR requires molybdopterin, iron-sulphur centres, and FAD as cofactors and has two interconvertible forms, xanthine oxidase and xanthine dehydrogenase, which transfer electrons from xanthine to oxygen and NAD(+), respectively, yielding superoxide, hydrogen peroxide and NADH.	Iron	28-32	xanthine dehydrogenase	Homo sapiens	128-150
14672929-5	2004	One FAD and three iron-sulfur clusters were docked into the Sdh1p and Sdh2p catalytic dimer.	Iron	18-22	succinate dehydrogenase flavoprotein subunit SDH1	Saccharomyces cerevisiae S288C	60-65
14672929-5	2004	One FAD and three iron-sulfur clusters were docked into the Sdh1p and Sdh2p catalytic dimer.	Iron	18-22	succinate dehydrogenase iron-sulfur protein subunit SDH2	Saccharomyces cerevisiae S288C	70-75
15105272-11	2004	Frataxin appears to regulate mitochondrial iron-sulfur cluster formation, and the neurologic and cardiac manifestations of Friedreich"s ataxia are due to iron-mediated mitochondrial toxicity.	Iron	43-47	frataxin	Homo sapiens	0-8
15065832-0	2004	Iron lung versus conventional mechanical ventilation in acute exacerbation of COPD.	Iron	0-4	COPD	Homo sapiens	78-82
15139402-7	2004	It is now considered that hepatic iron overload related to the combination of heterogeneous genetic traits and environmental factors, including alcoholism and viral hepatitis, precipitates the expression of PCT through the inhibition of uroporphyrinogen decarboxylase (Uro.D).	Iron	34-38	uroporphyrinogen decarboxylase	Homo sapiens	237-267
15139402-7	2004	It is now considered that hepatic iron overload related to the combination of heterogeneous genetic traits and environmental factors, including alcoholism and viral hepatitis, precipitates the expression of PCT through the inhibition of uroporphyrinogen decarboxylase (Uro.D).	Iron	34-38	uroporphyrinogen decarboxylase	Homo sapiens	269-274
15287192-3	2004	Cytochrome P4502E1 (CYP2E1) is a highly labile isoform which is not only involved in free radical generation, but has also been shown to be a source of iron in cisplatin-induced renal injury.	Iron	152-156	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	20-26
14563638-0	2004	Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes.	Iron	16-20	homeostatic iron regulator	Rattus norvegicus	73-76
14534306-5	2004	New or additional support for a role in copper and iron homeostasis is provided in this study for the gene products of AKR1, MRS4, PCA1, SSU1, TIS11, YBR047W, YHL035C, YHR045W, YLR047C, YLR126C, and YTP1.	Iron	51-55	palmitoyltransferase AKR1	Saccharomyces cerevisiae S288C	119-123
14534306-5	2004	New or additional support for a role in copper and iron homeostasis is provided in this study for the gene products of AKR1, MRS4, PCA1, SSU1, TIS11, YBR047W, YHL035C, YHR045W, YLR047C, YLR126C, and YTP1.	Iron	51-55	Ssu1p	Saccharomyces cerevisiae S288C	137-141
10070739-0	1999	An atypical iron-responsive element (IRE) within crayfish ferritin mRNA and an iron regulatory protein 1 (IRP1)-like protein from crayfish hepatopancreas.	Iron	12-16	aconitase 1	Homo sapiens	106-110
14973098-1	2004	Individuals with the major hemochromatosis (HFE) allele C282Y and iron overload develop hepatocellular and some extrahepatic malignancies at increased rates.	Iron	66-70	homeostatic iron regulator	Homo sapiens	44-47
9867873-2	1999	Iron regulatory proteins (IRP1 and IRP2) are redox-sensitive RNA-binding proteins that modulate the expression of several genes encoding key proteins of iron metabolism.	Iron	0-4	aconitase 1	Homo sapiens	26-30
9867873-2	1999	Iron regulatory proteins (IRP1 and IRP2) are redox-sensitive RNA-binding proteins that modulate the expression of several genes encoding key proteins of iron metabolism.	Iron	153-157	aconitase 1	Homo sapiens	26-30
15647788-1	2004	Iron regulatory protein 1 (IRP1) post-transcriptionally regulates the expression of proteins involved in the iron metabolism of mammals.	Iron	109-113	aconitase 1	Homo sapiens	0-25
9915882-2	1999	Although the exact functions of these proteins in intestinal iron absorption are unknown, HFE may be required for the down-regulation of iron absorption that occurs with increasing iron status, and Nramp2 may up-regulate iron absorption when iron status is low.	Iron	137-141	homeostatic iron regulator	Homo sapiens	90-93
9915882-2	1999	Although the exact functions of these proteins in intestinal iron absorption are unknown, HFE may be required for the down-regulation of iron absorption that occurs with increasing iron status, and Nramp2 may up-regulate iron absorption when iron status is low.	Iron	137-141	homeostatic iron regulator	Homo sapiens	90-93
9915882-3	1999	Thus, we examined whether the expression of the HFE and Nramp2 genes are regulated by iron status in the human intestinal cell line Caco-2.	Iron	86-90	homeostatic iron regulator	Homo sapiens	48-51
9915882-4	1999	HFE mRNA and HFE protein were increased and Nramp2 mRNA was decreased by increasing cellular iron status in Caco-2 cells.	Iron	93-97	homeostatic iron regulator	Homo sapiens	0-3
15647788-1	2004	Iron regulatory protein 1 (IRP1) post-transcriptionally regulates the expression of proteins involved in the iron metabolism of mammals.	Iron	109-113	aconitase 1	Homo sapiens	27-31
9915882-8	1999	This reciprocal modification of the HFE and Nramp2 gene expression during both iron treatment and cell differentiation in Caco-2 cells is consistent with an opposing role for these proteins in homeostatic regulation of human intestinal iron absorption.	Iron	79-83	homeostatic iron regulator	Homo sapiens	36-39
9915882-8	1999	This reciprocal modification of the HFE and Nramp2 gene expression during both iron treatment and cell differentiation in Caco-2 cells is consistent with an opposing role for these proteins in homeostatic regulation of human intestinal iron absorption.	Iron	236-240	homeostatic iron regulator	Homo sapiens	36-39
15647788-2	2004	IRP1 is a bifunctional cytosolic protein which can exhibit aconitase activity or bind to iron responsive element (IREs) in the untranslated regions of specific mRNAs.	Iron	89-93	aconitase 1	Homo sapiens	0-4
15647788-3	2004	The modulation of IRP1 activities and its consequence for intracellular iron homeostasis is best characterized in rodents and humans.	Iron	72-76	aconitase 1	Homo sapiens	18-22
15647788-5	2004	In this study, we analyzed the two activities of IRP1 in the livers of four farm animal species (cattle, goat, pig and rabbit) and their relationship to hepatic iron content.	Iron	161-165	aconitase 1	Homo sapiens	49-53
15647788-6	2004	We found an inverse correlation between spontaneous IRP1 IRE binding activity and non-haem iron content in the liver.	Iron	91-95	aconitase 1	Homo sapiens	52-56
10086886-2	1999	The aim of this study was to determine the effects of siderophores, which are iron-chelating molecules produced by a variety of microorganisms, on the activity of MMP-2.	Iron	78-82	matrix metallopeptidase 2	Homo sapiens	163-168
14732289-12	2004	Ferritin mRNA was also upregulated during all HO-1 induction by MCGA3, which might decrease iron and lower ROS levels.	Iron	92-96	heme oxygenase 1	Bos taurus	46-50
9918797-2	1998	SFT (stimulator of Fe transport) is a newly discovered transport protein that facilitates uptake of iron.	Iron	100-104	ubiquitin conjugating enzyme E2 D1	Homo sapiens	0-3
9918797-2	1998	SFT (stimulator of Fe transport) is a newly discovered transport protein that facilitates uptake of iron.	Iron	100-104	ubiquitin conjugating enzyme E2 D1	Homo sapiens	5-31
9918797-3	1998	Recent studies have demonstrated that although SFT expression is reciprocally regulated in response to cellular iron levels, it is aberrantly upregulated in the liver of hemochromatosis patients, indicating that enhanced SFT expression contributes to the etiology of this disease.	Iron	112-116	ubiquitin conjugating enzyme E2 D1	Homo sapiens	47-50
15495967-4	2004	BET specific surface area of the nanoscale Pd/Fe particles is 12.4 m2/g.	Iron	46-48	delta/notch like EGF repeat containing	Homo sapiens	0-3
9931446-7	1998	Knowledge of the identified conserved elements in the HFE promoter from human, mouse and rat provides the basis for subsequent in-vitro or in-vivo studies leading to identification of the detailed mechanisms involved in the regulation of the iron metabolism and the design of potential future alternative therapies.	Iron	242-246	homeostatic iron regulator	Homo sapiens	54-57
15538648-0	2004	The role of HFE mutations on iron metabolism in beta-thalassemia carriers.	Iron	29-33	homeostatic iron regulator	Homo sapiens	12-15
9856986-0	1998	Expression of SFT (stimulator of Fe transport) is enhanced by iron chelation in HeLa cells and by hemochromatosis in liver.	Iron	62-66	ubiquitin conjugating enzyme E2 D1	Homo sapiens	14-17
9856986-0	1998	Expression of SFT (stimulator of Fe transport) is enhanced by iron chelation in HeLa cells and by hemochromatosis in liver.	Iron	62-66	ubiquitin conjugating enzyme E2 D1	Homo sapiens	19-45
15538648-5	2004	The aim of this study was to evaluate the effect of genetic markers (HFE mutations C282Y, H63D, and S65C) on the iron status of beta-thalassemia carriers.	Iron	113-117	homeostatic iron regulator	Homo sapiens	69-72
9856986-1	1998	SFT (stimulator of Fe transport) is a novel transport protein that has been found to facilitate uptake of iron presented to cells as either Fe(II) or Fe(III).	Iron	106-110	ubiquitin conjugating enzyme E2 D1	Homo sapiens	0-3
9856986-1	1998	SFT (stimulator of Fe transport) is a novel transport protein that has been found to facilitate uptake of iron presented to cells as either Fe(II) or Fe(III).	Iron	106-110	ubiquitin conjugating enzyme E2 D1	Homo sapiens	5-31
9856986-2	1998	When HeLa cells are exposed to the iron chelator desferrioxamine, levels of SFT mRNA increase in an actinomycin D-sensitive manner.	Iron	35-39	ubiquitin conjugating enzyme E2 D1	Homo sapiens	76-79
9856986-3	1998	In contrast, cells exposed to high levels of iron down-regulate SFT expression in a time-dependent and reversible fashion.	Iron	45-49	ubiquitin conjugating enzyme E2 D1	Homo sapiens	64-67
9856986-4	1998	Thus, homeostatic regulation of SFT expression not only ensures that sufficient levels of iron are maintained but also limits excessive assimilation to prevent potentially harmful effects of this toxic metal.	Iron	90-94	ubiquitin conjugating enzyme E2 D1	Homo sapiens	32-35
9856986-5	1998	The unexpected observation that SFT transcript levels are up-regulated in hemochromatosis patients therefore suggests that enhanced SFT expression contributes to the etiology of this iron overload disorder.	Iron	183-187	ubiquitin conjugating enzyme E2 D1	Homo sapiens	32-35
14570713-1	2003	Frataxin protein controls iron availability in mitochondria and reduced levels lead to the human disease, Friedreich"s ataxia (FRDA).	Iron	26-30	frataxin	Homo sapiens	0-8
9856986-5	1998	The unexpected observation that SFT transcript levels are up-regulated in hemochromatosis patients therefore suggests that enhanced SFT expression contributes to the etiology of this iron overload disorder.	Iron	183-187	ubiquitin conjugating enzyme E2 D1	Homo sapiens	132-135
9844002-2	1998	In this communication, we describe the isolation and characterization of a unique series of DtxR mutants that are constitutively active and repress the expression of beta-galactosidase from a diphtheria tox promoter/operator-lacZ transcriptional fusion, even in the absence of iron.	Iron	277-281	galactosidase beta 1	Homo sapiens	166-184
14570713-1	2003	Frataxin protein controls iron availability in mitochondria and reduced levels lead to the human disease, Friedreich"s ataxia (FRDA).	Iron	26-30	frataxin	Homo sapiens	127-131
9844002-6	1998	Partial diploid analysis of strains carrying both native dtxR and alleles encoding either SAD2 or SAD3 demonstrate that these iron-independent mutants possess a positive dominant phenotype in the regulation of beta-galactosidase expression from a diphtheria tox promoter/operator-lacZ transcriptional fusion.	Iron	126-130	galactosidase beta 1	Homo sapiens	210-228
9844002-6	1998	Partial diploid analysis of strains carrying both native dtxR and alleles encoding either SAD2 or SAD3 demonstrate that these iron-independent mutants possess a positive dominant phenotype in the regulation of beta-galactosidase expression from a diphtheria tox promoter/operator-lacZ transcriptional fusion.	Iron	126-130	thymocyte selection associated high mobility group box	Homo sapiens	258-261
14570713-4	2003	Shutting off the promoter resulted in changes normally associated with loss of frataxin including iron accumulation within the mitochondria and the induction of mitochondrial petite mutants.	Iron	98-102	frataxin	Homo sapiens	79-87
12954629-2	2003	Fet3p is a multicopper oxidase in this membrane essential for high affinity iron uptake.	Iron	76-80	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
14703689-2	2003	When it is inherited together with a mutation in the HFE (HLA-H) gene associated with hereditary haemochromatosis, iron overload may ensue.	Iron	115-119	homeostatic iron regulator	Homo sapiens	53-56
9860493-2	1998	The objective of this study was to determine whether iron, present in coal fly ash, was mobilized, leading to ferritin induction in human airway epithelial cells, and whether the size of the particles affected the amount of iron mobilized.	Iron	53-57	Ferritin 1 heavy chain homologue	Drosophila melanogaster	110-118
9860493-10	1998	To determine if iron associated with the coal fly ash could be mobilized by A549 cells, cells were treated with coal fly ash, and the amount of the iron storage protein ferritin was determined after 24 h. Ferritin levels were increased by as much as 11.9-fold in cells treated with coal fly ash.	Iron	16-20	Ferritin 1 heavy chain homologue	Drosophila melanogaster	205-213
9860493-10	1998	To determine if iron associated with the coal fly ash could be mobilized by A549 cells, cells were treated with coal fly ash, and the amount of the iron storage protein ferritin was determined after 24 h. Ferritin levels were increased by as much as 11.9-fold in cells treated with coal fly ash.	Iron	148-152	Ferritin 1 heavy chain homologue	Drosophila melanogaster	205-213
9860493-12	1998	Further, inhibition of the endocytosis of the coal fly ash by the cells resulted in ferritin levels that were near that of the untreated cells, suggesting that iron was mobilized intracellularly, not in the culture medium.	Iron	160-164	Ferritin 1 heavy chain homologue	Drosophila melanogaster	84-92
14632497-3	2003	Reaction of [Fe(6)O(2)(OH)(2)(O(2)CR)(10)(hep)(2)] (R = Bu(t) or Ph) with PhOH affords the new "ferric wheel" complexes [Fe(8)(OH)(4)(OPh)(8)(O(2)CR)(12)] [R = Bu(t) (2) or Ph (3)].	Iron	13-15	EPH receptor B6	Homo sapiens	42-45
9862796-1	1998	BACKGROUND: The translation or stability of the mRNAs from ferritin, maconitase, erythroid aminoevulinate synthase and the transferrin receptor is controlled by the binding of two iron regulatory proteins to a family of hairpin-forming RNA sequences called iron-responsive elements (IREs).	Iron	180-184	serotransferrin	Oryctolagus cuniculus	123-134
9862796-1	1998	BACKGROUND: The translation or stability of the mRNAs from ferritin, maconitase, erythroid aminoevulinate synthase and the transferrin receptor is controlled by the binding of two iron regulatory proteins to a family of hairpin-forming RNA sequences called iron-responsive elements (IREs).	Iron	257-261	serotransferrin	Oryctolagus cuniculus	123-134
9851861-5	1998	A cross-linked, high-molecular-weight derivative of soybean trypsin inhibitor (hMW-SBTI) which was unable to pass through the elevating FE blocked the loss of both immunoreactivity and the sperm binding activity of the FE, but did not inhibit the vitelline delaminase activity that has been implicated in FE formation.	Iron	219-221	cilia and flagella associated protein 97	Homo sapiens	79-82
9851861-5	1998	A cross-linked, high-molecular-weight derivative of soybean trypsin inhibitor (hMW-SBTI) which was unable to pass through the elevating FE blocked the loss of both immunoreactivity and the sperm binding activity of the FE, but did not inhibit the vitelline delaminase activity that has been implicated in FE formation.	Iron	219-221	cilia and flagella associated protein 97	Homo sapiens	79-82
14972004-14	2003	CONCLUSIONS: our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis.	Iron	141-145	homeostatic iron regulator	Homo sapiens	92-95
9885568-0	1998	Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization.	Iron	21-25	NFS1 cysteine desulfurase	Homo sapiens	58-62
9885568-2	1998	Here we report cloning of the human homolog of NifS, a cysteine desulfurase that is proposed to supply the inorganic sulfur in iron-sulfur clusters.	Iron	127-131	NFS1 cysteine desulfurase	Homo sapiens	47-51
12960168-3	2003	These genes, FET3, FTR1, TIS11, SIT1, and FIT2, are involved in the iron uptake pathway.	Iron	68-72	ferroxidase FET3	Saccharomyces cerevisiae S288C	13-17
9819237-1	1998	The aromatic amino acid hydroxylases tyrosine and phenylalanine hydroxylase both contain non-heme iron, utilize oxygen and tetrahydrobiopterin, and are tetramers of identical subunits.	Iron	98-102	phenylalanine hydroxylase	Homo sapiens	50-75
9819237-3	1998	The hydroxyl oxygens of tyrosine 371 in tyrosine hydroxylase and of tyrosine 325 of phenylalanine hydroxylase are 5 and 4.5 A, respectively, away from the active site iron in the enzymes.	Iron	167-171	phenylalanine hydroxylase	Homo sapiens	84-109
12960168-3	2003	These genes, FET3, FTR1, TIS11, SIT1, and FIT2, are involved in the iron uptake pathway.	Iron	68-72	Fit2p	Saccharomyces cerevisiae S288C	42-46
14563924-3	2003	A 1.6-A crystal structure of P450 2B4 reveals a large open cleft that extends from the protein surface directly to the heme iron between the alpha-helical and beta-sheet domains without perturbing the overall P450 fold.	Iron	124-128	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	29-33
9808757-1	1998	Ferrochelatase (EC 4.99.1.1) catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.	Iron	56-68	ferrochelatase	Gallus gallus	0-14
12855587-1	2003	Iron regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that affect the translation and stabilization of specific mRNAs by binding to stem-loop structures known as iron responsive elements (IREs).	Iron	174-178	aconitase 1	Homo sapiens	26-30
9813392-6	1998	Surprisingly, the observed inhibition by Cu2+ and Cd2+ was dependent on the iron redox state, since neither cation inhibited Fe3+ uptake by mouse duodenum.	Iron	76-80	CD2 antigen	Mus musculus	50-53
9813392-8	1998	These results indicate that inhibition of iron uptake by Cu2+ and Cd2+ takes place only in a reducing environment.	Iron	42-46	CD2 antigen	Mus musculus	66-69
12855587-4	2003	Here we describe the consequences of IRP regulation and show that iron homeostasis is regulated in 2 phases during hypoxia: an early phase where IRP1 RNA-binding activity decreases and iron uptake and Ft synthesis increase, and a late phase where IRP2 RNA-binding activity increases and iron uptake and Ft synthesis decrease.	Iron	66-70	aconitase 1	Homo sapiens	145-149
9801065-10	1998	Iron supplementation has resulted in decreased mobilization of stored iron as reflected by increased mucosal ferritin level and decreased serum ceruloplasmin ferroxidase activity contributing to greater peroxidative stress in the intestine.	Iron	0-4	ceruloplasmin	Rattus norvegicus	144-169
14578853-6	2003	Arachidonic acid (AA) plus iron-induced cell death was partially prevented in both Ad.SOD1- and Ad.SOD2-infected E47 cells.	Iron	27-31	superoxide dismutase 2	Homo sapiens	99-103
14578853-7	2003	Overexpression of Cu/Zn-SOD and Mn-SOD also partially protected E47 cells from the increase in reactive oxygen production and lipid peroxidation and the loss of mitochondrial membrane potential induced by AA and iron.	Iron	212-216	superoxide dismutase 2	Homo sapiens	32-38
14526117-0	2003	Overexpression of the FRO2 ferric chelate reductase confers tolerance to growth on low iron and uncovers posttranscriptional control.	Iron	87-91	ferric reduction oxidase 2	Arabidopsis thaliana	22-26
9746616-2	1998	In a plate bioassay, all six strains acquired iron from ferrous chloride, ferric chloride, ferrous sulfate, ferric ammonium citrate, ferrous ammonium sulfate, bovine and equine hemin, bovine catalase, and equine, bovine, rabbit, and human hemoglobin.	Iron	46-50	catalase	Bos taurus	191-199
14526117-1	2003	The Arabidopsis FRO2 gene encodes the low-iron-inducible ferric chelate reductase responsible for reduction of iron at the root surface.	Iron	42-46	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
14526117-1	2003	The Arabidopsis FRO2 gene encodes the low-iron-inducible ferric chelate reductase responsible for reduction of iron at the root surface.	Iron	111-115	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
9731075-8	1998	The G185R mutation, however, causes near total loss of Nramp2 function that cannot be fully explained by a decreased amount of protein, indicating that G185R disrupts iron transport through an alteration in the function of Nramp2, rather than degradation of the protein.	Iron	167-171	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	55-61
9731075-8	1998	The G185R mutation, however, causes near total loss of Nramp2 function that cannot be fully explained by a decreased amount of protein, indicating that G185R disrupts iron transport through an alteration in the function of Nramp2, rather than degradation of the protein.	Iron	167-171	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	223-229
14526117-2	2003	Here, we report that FRO2 and IRT1, the major transporter responsible for high-affinity iron uptake from the soil, are coordinately regulated at both the transcriptional and posttranscriptional levels.	Iron	88-92	ferric reduction oxidase 2	Arabidopsis thaliana	21-25
14526117-3	2003	FRO2 and IRT1 are induced together following the imposition of iron starvation and are coordinately repressed following iron resupply.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
14526117-3	2003	FRO2 and IRT1 are induced together following the imposition of iron starvation and are coordinately repressed following iron resupply.	Iron	120-124	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
9726965-9	1998	Variations in IRE structure and cellular IRP1/IRP2 ratios can provide a range of finely tuned, mRNA-specific responses to the same (iron) signal.	Iron	132-136	aconitase 1	Homo sapiens	41-45
14526117-5	2003	Like IRT1, FRO2 mRNA is detected in the epidermal cells of roots, consistent with its proposed role in iron uptake from the soil.	Iron	103-107	ferric reduction oxidase 2	Arabidopsis thaliana	11-15
9726978-6	1998	Expression of FRE3-FRE6 is elevated in AFT1-1 cells and attenuated in aft1 null cells, showing that iron modulation occurs through the Aft1 transcriptional activator.	Iron	100-104	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	19-23
14526117-8	2003	Finally, the 35S-FRO2 plants grow better on low iron as compared with wild-type plants, supporting the idea that reduction of ferric iron to ferrous iron is the rate-limiting step in iron uptake.	Iron	48-52	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
14526117-8	2003	Finally, the 35S-FRO2 plants grow better on low iron as compared with wild-type plants, supporting the idea that reduction of ferric iron to ferrous iron is the rate-limiting step in iron uptake.	Iron	133-137	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
14526117-8	2003	Finally, the 35S-FRO2 plants grow better on low iron as compared with wild-type plants, supporting the idea that reduction of ferric iron to ferrous iron is the rate-limiting step in iron uptake.	Iron	133-137	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
14559969-3	2003	Although not detectable without DNA, the redox potential of DNA-bound MutY is approximately 275 mV versus NHE, which is characteristic of HiPiP iron proteins.	Iron	144-148	solute carrier family 9 member C1	Homo sapiens	106-109
9722559-1	1998	High affinity iron uptake in Saccharomyces cerevisiae requires Fet3p.	Iron	14-18	ferroxidase FET3	Saccharomyces cerevisiae S288C	63-68
9722559-2	1998	Fet3p is proposed to facilitate iron uptake by catalyzing the oxidation of Fe(II) to Fe(III) by O2; in this model, Fe(III) is the substrate for the iron permease, encoded by FTR1.	Iron	32-36	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
14550302-0	2003	Iron toxicity protection by truncated Ras2 GTPase in yeast strain lacking frataxin.	Iron	0-4	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	38-42
9748693-6	1998	The new TFR polymorphisms and haplotypes may also be useful markers in studies of interactions with the transferrin and hemochromatosis genes, the genetic influence on body iron stores and disease associations.	Iron	173-177	transferrin receptor	Homo sapiens	8-11
9778136-6	1998	Rats with the lowest dietary iron supply had higher concentrations of hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE), lower activities of glucose-6-phosphate dehydrogenase, malic enzyme and fatty acid synthase, and higher triacylglycerol concentrations in serum lipoproteins than the corresponding pair-fed control rats.	Iron	29-33	glucose-6-phosphate dehydrogenase	Rattus norvegicus	158-191
14550302-0	2003	Iron toxicity protection by truncated Ras2 GTPase in yeast strain lacking frataxin.	Iron	0-4	frataxin	Homo sapiens	74-82
14550302-1	2003	Yeast strain deleted for the YFH1 gene, which encodes the orthologue of human frataxin, accumulates iron in mitochondria, constitutively activates the high-affinity iron import system in the plasma membrane, and is sensitive to high iron media.	Iron	100-104	frataxin	Homo sapiens	78-86
9714152-1	1998	In order to characterize the mechanism by which Iron (Fe) is taken up by neurons, we examined the neuronal expression of transferrin receptor (TR) in rats during development and iron (Fe) deficiency by using immunohistochemistry, in vitro receptor autoradiography and in situ hybridization.	Iron	48-52	transferrin receptor	Rattus norvegicus	143-145
9714152-1	1998	In order to characterize the mechanism by which Iron (Fe) is taken up by neurons, we examined the neuronal expression of transferrin receptor (TR) in rats during development and iron (Fe) deficiency by using immunohistochemistry, in vitro receptor autoradiography and in situ hybridization.	Iron	54-56	transferrin receptor	Rattus norvegicus	121-141
14550302-1	2003	Yeast strain deleted for the YFH1 gene, which encodes the orthologue of human frataxin, accumulates iron in mitochondria, constitutively activates the high-affinity iron import system in the plasma membrane, and is sensitive to high iron media.	Iron	165-169	frataxin	Homo sapiens	78-86
9714152-1	1998	In order to characterize the mechanism by which Iron (Fe) is taken up by neurons, we examined the neuronal expression of transferrin receptor (TR) in rats during development and iron (Fe) deficiency by using immunohistochemistry, in vitro receptor autoradiography and in situ hybridization.	Iron	54-56	transferrin receptor	Rattus norvegicus	143-145
9714152-3	1998	Reducing the Fe stores potentiated the expression of TR immunoreactivity in neurons of both young and adult rats in several grey matter regions.	Iron	13-15	transferrin receptor	Rattus norvegicus	53-55
14550302-1	2003	Yeast strain deleted for the YFH1 gene, which encodes the orthologue of human frataxin, accumulates iron in mitochondria, constitutively activates the high-affinity iron import system in the plasma membrane, and is sensitive to high iron media.	Iron	165-169	frataxin	Homo sapiens	78-86
14566406-7	2003	These observations suggest that DMT1 is possibly involved in the process of iron accumulation in SN of MPTP-treated mice, which might be responsible for the subsequent death of DA neurons.	Iron	76-80	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	32-36
9705350-0	1998	Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.	Iron	150-154	homeostatic iron regulator	Homo sapiens	18-21
9705350-1	1998	The mechanism by which a novel major histocompatibility complex class I protein, HFE, regulates iron uptake into the body is not known.	Iron	96-100	homeostatic iron regulator	Homo sapiens	81-84
12949888-9	2003	A significant portion of the iron transport proteins was localized in the goblet cells and outside the cell in the luminal mucin, as demonstrated by immunofluorescence, electron microscopy, and isolation of the mucin by cesium chloride gradient centrifugation and Western analysis.	Iron	29-33	LOC100508689	Homo sapiens	123-128
9705350-23	1998	These results implicate HFE further in the modulation of iron levels in the cell.	Iron	57-61	homeostatic iron regulator	Homo sapiens	24-27
9705865-1	1998	Ferritin is an intracellular iron storage protein whose synthesis is regulated post-transcriptionally by a mechanism that involves binding of cytoplasmic iron regulatory protein (IRP) to iron-responsive element (IRE) in the 5" untranslated region of ferritin mRNA.	Iron	29-33	wingless-type MMTV integration site family, member 2	Mus musculus	154-177
9705865-1	1998	Ferritin is an intracellular iron storage protein whose synthesis is regulated post-transcriptionally by a mechanism that involves binding of cytoplasmic iron regulatory protein (IRP) to iron-responsive element (IRE) in the 5" untranslated region of ferritin mRNA.	Iron	29-33	wingless-type MMTV integration site family, member 2	Mus musculus	179-182
12949888-9	2003	A significant portion of the iron transport proteins was localized in the goblet cells and outside the cell in the luminal mucin, as demonstrated by immunofluorescence, electron microscopy, and isolation of the mucin by cesium chloride gradient centrifugation and Western analysis.	Iron	29-33	LOC100508689	Homo sapiens	211-216
9705865-1	1998	Ferritin is an intracellular iron storage protein whose synthesis is regulated post-transcriptionally by a mechanism that involves binding of cytoplasmic iron regulatory protein (IRP) to iron-responsive element (IRE) in the 5" untranslated region of ferritin mRNA.	Iron	154-158	wingless-type MMTV integration site family, member 2	Mus musculus	179-182
12867346-1	2003	Discoloration and mineralization of Reactive Red HE-3B were studied by using a laponite clay-based Fe nanocomposite (Fe-Lap-RD) as a heterogeneous catalyst in the presence of H2O2 and UV light.	Iron	99-101	epididymal protein 3B	Homo sapiens	49-54
9687445-1	1998	The rbo gene of Desulfovibrio vulgaris Hildenborough encodes rubredoxin oxidoreductase (Rbo), a 14-kDa iron sulfur protein; forms an operon with the gene for rubredoxin; and is preceded by the gene for the oxygen-sensing protein DcrA.	Iron	103-107	DVU3184	Desulfovibrio vulgaris str. Hildenborough	61-71
12837693-2	2003	Five hypotheses for frataxin"s mitochondrial function have been generated, largely from work in non-human cells: iron transporter, iron-sulfur cluster assembler, iron-storage protein, antioxidant and stimulator of oxidative phosphorylation.	Iron	131-135	frataxin	Homo sapiens	20-28
9793248-4	1998	The sensitivity and specificity of serum TfR was evaluated according to the results of bone marrow iron status.	Iron	99-103	transferrin receptor	Homo sapiens	41-44
12832620-8	2003	These mutants thus provide unique models for exploring how the endocytic function of mouse Picalm and the transport processes mediated by clathrin and the AP2 complex contribute to normal hematopoiesis, iron metabolism, and growth.	Iron	203-207	transcription factor AP-2, alpha	Mus musculus	155-158
9708518-7	1998	In the other, the human transferrin receptor has been restored by transfection and is over-expressed constitutively, without the necessity to manipulate factors such as cell growth or iron content.	Iron	184-188	transferrin receptor	Homo sapiens	24-44
12819036-12	2003	Fe-induced injury suppressed HK-2 cell SR-B1, ABCA-1, and their mRNAs.	Iron	0-2	scavenger receptor class B, member 1	Mus musculus	39-44
10732799-1	1998	Most cases of Friedreich ataxia (FRDA) are due to expansions of a GAA trinucleotide repeat sequence in the FRDA gene coding for frataxin, a protein of poorly understood function which may regulate mitochondrial iron transport.	Iron	211-215	frataxin	Homo sapiens	14-31
10732799-1	1998	Most cases of Friedreich ataxia (FRDA) are due to expansions of a GAA trinucleotide repeat sequence in the FRDA gene coding for frataxin, a protein of poorly understood function which may regulate mitochondrial iron transport.	Iron	211-215	frataxin	Homo sapiens	33-37
10732799-1	1998	Most cases of Friedreich ataxia (FRDA) are due to expansions of a GAA trinucleotide repeat sequence in the FRDA gene coding for frataxin, a protein of poorly understood function which may regulate mitochondrial iron transport.	Iron	211-215	frataxin	Homo sapiens	107-111
10732799-1	1998	Most cases of Friedreich ataxia (FRDA) are due to expansions of a GAA trinucleotide repeat sequence in the FRDA gene coding for frataxin, a protein of poorly understood function which may regulate mitochondrial iron transport.	Iron	211-215	frataxin	Homo sapiens	128-136
9662273-1	1998	Homozygosity for the mutation Cys282Tyr in the HFE gene has recently been identified as a cause of hereditary hemochromatosis, a disorder resulting in the inappropriate absorption of iron.	Iron	183-187	homeostatic iron regulator	Homo sapiens	47-50
12820873-3	2003	The cluster-free protein (apo-IRP1) is a transregulator binding to specific mRNA, and thus post-transcriptionally modulating the expression of genes involved in iron metabolism.	Iron	161-165	aconitase 1	Homo sapiens	30-34
9657110-1	1998	Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE).	Iron	66-70	transferrin receptor	Rattus norvegicus	0-20
9657110-1	1998	Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE).	Iron	66-70	transferrin receptor	Rattus norvegicus	22-25
12820873-4	2003	The resonance Raman (RR) spectra of human recombinant holo-IRP1 (rhIRP1) excited at 457.9 nm show that the 395 cm(-1) band, attributed to a terminal Fe-S stretching mode of the cluster, is replaced by a 405 cm(-1) band, consistent with the conversion of the [4Fe-4S](2+) center to a [3Fe-4S](+) center, upon exposure to peroxynitrite.	Iron	149-153	aconitase 1	Homo sapiens	59-63
9657110-1	1998	Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE).	Iron	66-70	aconitase 1	Rattus norvegicus	178-183
9657110-1	1998	Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE).	Iron	152-156	transferrin receptor	Rattus norvegicus	0-20
14534614-1	2003	Lycopine in concentrations of 0.5-50 microM suppressed LPO in microsomes induced by NADPH-Fe(2+) and by ascorbic acid-Fe(2+).	Iron	90-92	lactoperoxidase	Rattus norvegicus	55-58
9657110-1	1998	Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE).	Iron	152-156	transferrin receptor	Rattus norvegicus	22-25
9657110-2	1998	IRP, in response to specific stimuli (low iron levels, growth and stress signals) are activated and prevent TfR mRNA degradation and ferritin mRNA translation by hindering ferritin mRNA binding to polysomes.	Iron	42-46	caspase 3	Rattus norvegicus	0-3
9657110-2	1998	IRP, in response to specific stimuli (low iron levels, growth and stress signals) are activated and prevent TfR mRNA degradation and ferritin mRNA translation by hindering ferritin mRNA binding to polysomes.	Iron	42-46	transferrin receptor	Rattus norvegicus	108-111
17003017-8	2003	By logistic regression analysis the parameters characterizing the offspring of parents with DM2 were IRI (OR 14.9 CI 2.4-91.0) serum iron (OR 44.2 CI 6.9-281), TIBC (OR 6.1 CI 1.01-37.0 and gamma-GT (OR 29.6 CI 5.0-174).	Iron	133-137	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	92-95
9673397-9	1998	Since the cytotoxicity of Ga-PIH appears to be less influenced by extracellular iron and cellular transferrin receptor expression, it may have potential as an antineoplastic agent and should be further evaluated in animal tumor models.	Iron	80-84	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	29-32
17003017-9	2003	In conclusion, the data indicate that the iron load, is significantly increased in offspring of DM2 subjects with unaffected glucose tolerance.	Iron	42-46	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	96-99
12684851-0	2003	Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase Fet3p from Saccharomyces cerevisiae.	Iron	44-48	ferroxidase FET3	Saccharomyces cerevisiae S288C	99-104
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	13-17	transferrin receptor	Homo sapiens	206-226
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	13-17	transferrin receptor	Homo sapiens	228-231
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	74-78	transferrin receptor	Homo sapiens	206-226
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	74-78	transferrin receptor	Homo sapiens	228-231
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	74-78	transferrin receptor	Homo sapiens	206-226
9672759-1	1998	The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron-containing proteins, and one of the main molecules involved is the transferrin receptor (TfR), which mediates the uptake process via the transferrin cycle.	Iron	74-78	transferrin receptor	Homo sapiens	228-231
12684851-2	2003	Fet3p catalyzes the oxidation of Fe(2+) to Fe(3+); this ferroxidation reaction is an obligatory first step in high-affinity iron uptake through the permease Ftr1p.	Iron	124-128	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
9672759-2	1998	The TfR expression is tightly regulated by factors such as intracellular iron level, cell proliferation or erythropoiesis at levels of receptor recycling, transcriptional or posttranscriptional control.	Iron	73-77	transferrin receptor	Homo sapiens	4-7
9672759-7	1998	The regulation of TfR expression in various tissues is related to its specific cellular iron requirements.	Iron	88-92	transferrin receptor	Homo sapiens	18-21
12767048-11	2003	However, iron status had no significant effect on DMT1 (IRE) and DMT1 (non-IRE) mRNAs expression in the heart, although it can significantly influence heart transferrin receptor (TfR) mRNA expression.	Iron	9-13	transferrin receptor	Rattus norvegicus	157-177
9672759-9	1998	For most non-erythroid cells, iron can regulate the TfR expression in a reciprocal manner through modulating the stability of the receptor mRNA whereas in hemoglobin-synthesizing cells, the TfR expression is independent of the cellular iron loading.	Iron	30-34	transferrin receptor	Homo sapiens	52-55
9672759-9	1998	For most non-erythroid cells, iron can regulate the TfR expression in a reciprocal manner through modulating the stability of the receptor mRNA whereas in hemoglobin-synthesizing cells, the TfR expression is independent of the cellular iron loading.	Iron	30-34	transferrin receptor	Homo sapiens	190-193
9672759-10	1998	In spite of a wide heterogeneity in the way receptor redistribution is in response to various stimuli, regulation of the constitutive expression of TfR is one of the ways of regulating the cellular iron uptake.	Iron	198-202	transferrin receptor	Homo sapiens	148-151
9545294-10	1998	Inactivation of XylE by 4-methylcatechol resulted in oxidation of the active site iron to a high spin ferric state that was detectable by EPR.	Iron	82-86	catechol 2,3-dioxygenase	Pseudomonas putida	16-20
9545294-11	1998	Spectroscopic evidence presented here demonstrates that XylT reactivates XylE through reduction of the iron atom in the active site of the enzyme.	Iron	103-107	catechol 2,3-dioxygenase	Pseudomonas putida	73-77
12767048-11	2003	However, iron status had no significant effect on DMT1 (IRE) and DMT1 (non-IRE) mRNAs expression in the heart, although it can significantly influence heart transferrin receptor (TfR) mRNA expression.	Iron	9-13	transferrin receptor	Rattus norvegicus	179-182
12856975-6	2003	The TfR concentrations were significantly lower after iron therapy than before treatment.	Iron	54-58	transferrin receptor	Homo sapiens	4-7
9521817-1	1998	We previously reported that the heavy chain of ferritin was required for loading it with iron using ceruloplasmin as a ferroxidase [J.-H. Guo, M. Abedi, and S. D. Aust (1996) Arch.	Iron	89-93	ceruloplasmin	Rattus norvegicus	100-113
12856975-9	2003	TfR concentrations were significantly lower after iron therapy.	Iron	50-54	transferrin receptor	Homo sapiens	0-3
9521817-8	1998	The rH-Ft mutant homopolymer could not be loaded, whereas the rL-Ft mutant homopolymer could be loaded with iron by ceruloplasmin.	Iron	108-112	ceruloplasmin	Rattus norvegicus	116-129
12806616-0	2003	Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.	Iron	66-70	glutamic--pyruvic transaminase	Homo sapiens	27-51
9521817-9	1998	However, we found that the initial rate of iron loading into the rL-Ft mutant homopolymer by ceruloplasmin was less than that into the rH-Ft homopolymer.	Iron	43-47	ceruloplasmin	Rattus norvegicus	93-106
9521817-10	1998	When 500 atoms of iron per ferritin were used for loading, 98% was loaded into the rH-Ft homopolymer by ceruloplasmin in 15 min, but only 30% was loaded into the rL-Ft mutant homopolymer in the same time.	Iron	18-22	ceruloplasmin	Rattus norvegicus	104-117
9521817-12	1998	These observations suggested that the four alpha-helix bundle channel of ferritin is required for iron loading, but an additional factor, i.e. , a site which stimulate the ferroxidase activity of ceruloplasmin, is also essential.	Iron	98-102	ceruloplasmin	Rattus norvegicus	196-209
12763366-2	2003	We conducted a population-based study in Spain to asses the prevalence of the HFE mutations and their effect on iron parameters.	Iron	112-116	homeostatic iron regulator	Homo sapiens	78-81
9516158-2	1998	We previously found that RE cells from GH patients had an inappropriately high activity of iron regulatory protein (IRP), the key regulator of intracellular iron homeostasis.	Iron	91-95	Wnt family member 2	Homo sapiens	116-119
9516158-3	1998	Elevated IRP should reflect a reduction of the iron pool, possibly because of a failure to retain iron.	Iron	47-51	Wnt family member 2	Homo sapiens	9-12
12749025-6	2003	Moreover, GLP-1 and exendin-4 protect cultured hippocampal neurons against death induced by Abeta and iron, an oxidative insult.	Iron	102-106	glucagon like peptide 1 receptor	Homo sapiens	10-15
9537361-1	1998	Secretion of the Escherichia coli toxin colicin V was previously determined to be iron regulated via the Fur (ferric uptake regulator) protein, based on studies in fur mutants.	Iron	82-86	Colicin V	Escherichia coli	40-49
12785837-1	2003	Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins.	Iron	35-39	frataxin	Homo sapiens	20-28
12785837-3	2003	The intermediate [2Fe-2S] ISU-bound cluster is formed by delivery of iron and sulfur to the apo ISU, with the latter delivered through an IscS-mediated reaction.	Iron	69-73	NFS1 cysteine desulfurase	Homo sapiens	138-142
12785837-5	2003	In this paper we demonstrate human frataxin to bind from six to seven iron ions.	Iron	70-74	frataxin	Homo sapiens	35-43
12785837-6	2003	Iron binding to frataxin has been quantitated by iron-dependent fluorescence measurements [K(D)(Fe(3+)) approximately 11.7 microM; (K(D)(Fe(2+)) approximately 55.0 microM] and isothermal titration calorimetry (ITC) [K(D)(Fe(3+)) approximately 10.2 microM].	Iron	0-4	frataxin	Homo sapiens	16-24
12785837-6	2003	Iron binding to frataxin has been quantitated by iron-dependent fluorescence measurements [K(D)(Fe(3+)) approximately 11.7 microM; (K(D)(Fe(2+)) approximately 55.0 microM] and isothermal titration calorimetry (ITC) [K(D)(Fe(3+)) approximately 10.2 microM].	Iron	49-53	frataxin	Homo sapiens	16-24
12785837-10	2003	Holo frataxin is also shown to mediate the transfer of iron from holo frataxin to nucleation sites for [2Fe-2S] cluster formation on ISU.	Iron	55-59	frataxin	Homo sapiens	5-13
12785837-10	2003	Holo frataxin is also shown to mediate the transfer of iron from holo frataxin to nucleation sites for [2Fe-2S] cluster formation on ISU.	Iron	55-59	frataxin	Homo sapiens	70-78
12785837-15	2003	2002, 124, 8774-8775] that this iron-bound form of ISU is viable for assembly of holo ISU, either by subsequent addition of sulfide or by NifS-mediated sulfur delivery.	Iron	32-36	NFS1 cysteine desulfurase	Homo sapiens	138-142
12785837-21	2003	Similar rates were obtained for NifS-mediated sulfur delivery, consistent with iron release from frataxin as a rate-limiting step in the cluster assembly reaction.	Iron	79-83	frataxin	Homo sapiens	97-105
12737949-0	2003	Hemochromatosis gene (HFE) mutations in South East Asia: a potential for iron overload.	Iron	73-77	homeostatic iron regulator	Homo sapiens	22-25
12727869-6	2003	Pos5p is localized to the mitochondrial matrix of yeast and appears to be important for several NADPH-requiring processes in the mitochondria, including resistance to a broad range of oxidative stress conditions, arginine biosynthesis and mitochondrial iron homeostasis.	Iron	253-257	NADH kinase	Saccharomyces cerevisiae S288C	0-5
12724383-4	2003	Primer extension analysis revealed that the iutA gene is transcribed in response to low-iron availability from a putative promoter overlapped with a sequence resembling a consensus E. coli Fur-binding sequence.	Iron	88-92	Aerobactin siderophore ferric receptor protein IutA	Escherichia coli	44-48
12724383-6	2003	Moreover, insertional inactivation of iutA impaired growth in the presence of aerobactin and incapacitated the outer-membrane fraction from iron-deficient cells for binding (55)Fe-labelled aerobactin.	Iron	140-144	Aerobactin siderophore ferric receptor protein IutA	Escherichia coli	38-42
12724383-6	2003	Moreover, insertional inactivation of iutA impaired growth in the presence of aerobactin and incapacitated the outer-membrane fraction from iron-deficient cells for binding (55)Fe-labelled aerobactin.	Iron	177-179	Aerobactin siderophore ferric receptor protein IutA	Escherichia coli	38-42
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	35-39	transferrin receptor	Rattus norvegicus	51-71
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	35-39	transferrin receptor	Rattus norvegicus	73-76
12696880-0	2003	Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron.	Iron	159-163	phenylalanine hydroxylase	Homo sapiens	41-66
12696880-1	2003	Phenylalanine hydroxylase, a mononuclear non-heme iron enzyme, catalyzes the hydroxylation of phenylalanine to tyrosine in the presence of oxygen and reduced pterin cofactor.	Iron	50-54	phenylalanine hydroxylase	Homo sapiens	0-25
12696880-3	2003	One such interaction involves Tyr325 in human phenylalanine hydroxylase (hPAH), which forms a hydrogen-bonding network with an aqua ligand on iron and the pterin cofactor.	Iron	142-146	phenylalanine hydroxylase	Homo sapiens	46-71
12696880-3	2003	One such interaction involves Tyr325 in human phenylalanine hydroxylase (hPAH), which forms a hydrogen-bonding network with an aqua ligand on iron and the pterin cofactor.	Iron	142-146	phenylalanine hydroxylase	Homo sapiens	73-77
12480705-6	2003	Furthermore, in vitro and in vivo pull-down assays revealed that ABC7 protein is interacted with the carboxy-terminal region containing the iron-sulfur cluster of ferrochelatase.	Iron	140-144	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	65-69
12480705-11	2003	The results indicated that ABC7 positively regulates not only the expression of extramitochondrial thioredoxin but also that of an intramitochondrial iron-sulfur-containing protein, ferrochelatase.	Iron	150-154	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	27-31
12480712-0	2003	UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.	Iron	103-107	ubiquitin conjugating enzyme E2 D1	Homo sapiens	0-6
12523938-13	2003	Overall, these results suggest that MPP(+)-induced cell death in CGNs and neuroblastoma cells proceeds via apoptosis and involves mitochondrial release of ROS and TfR-dependent iron.	Iron	177-181	transferrin receptor	Homo sapiens	163-166
12456502-0	2003	A single viral protein HCMV US2 affects antigen presentation and intracellular iron homeostasis by degradation of classical HLA class I and HFE molecules.	Iron	79-83	homeostatic iron regulator	Homo sapiens	140-143
12456502-2	2003	HFE accumulates in transferrin-containing endosomes, and its overexpression in human cell lines correlates with decreased transferrin receptor (TFR)-mediated iron uptake and decreased intracellular iron pools.	Iron	158-162	homeostatic iron regulator	Homo sapiens	0-3
12456502-2	2003	HFE accumulates in transferrin-containing endosomes, and its overexpression in human cell lines correlates with decreased transferrin receptor (TFR)-mediated iron uptake and decreased intracellular iron pools.	Iron	158-162	transferrin receptor	Homo sapiens	122-142
12456502-2	2003	HFE accumulates in transferrin-containing endosomes, and its overexpression in human cell lines correlates with decreased transferrin receptor (TFR)-mediated iron uptake and decreased intracellular iron pools.	Iron	158-162	transferrin receptor	Homo sapiens	144-147
12456502-2	2003	HFE accumulates in transferrin-containing endosomes, and its overexpression in human cell lines correlates with decreased transferrin receptor (TFR)-mediated iron uptake and decreased intracellular iron pools.	Iron	198-202	homeostatic iron regulator	Homo sapiens	0-3
12456502-4	2003	We previously suggested that viruses could also interfere with iron metabolism through the production of proteins that inactivate HFE, similarly to classical class I proteins.	Iron	63-67	homeostatic iron regulator	Homo sapiens	130-133
12456502-8	2003	This HCMV US2-mediated degradation of HFE leads to increased intracellular iron pools as indicated by reduced synthesis of TfR and increased ferritin synthesis.	Iron	75-79	homeostatic iron regulator	Homo sapiens	38-41
12456502-8	2003	This HCMV US2-mediated degradation of HFE leads to increased intracellular iron pools as indicated by reduced synthesis of TfR and increased ferritin synthesis.	Iron	75-79	transferrin receptor	Homo sapiens	123-126
12618146-1	2003	Fluorescence quenching was used to study the kinetics of the transferrin receptor (TfR)-mediated iron uptake in the calcein-loaded K562 cells.	Iron	97-101	transferrin receptor	Homo sapiens	61-81
12618146-1	2003	Fluorescence quenching was used to study the kinetics of the transferrin receptor (TfR)-mediated iron uptake in the calcein-loaded K562 cells.	Iron	97-101	transferrin receptor	Homo sapiens	83-86
12656741-2	2003	HFE, the protein defective in hereditary hemochromatosis, and transferrin receptor 2 (TfR2) are two novel protein candidates that could be involved in mechanisms of iron transport across the platelet plasma membrane.	Iron	165-169	homeostatic iron regulator	Homo sapiens	0-3
12681966-0	2003	Analysis of HFE and TFR2 mutations in selected blood donors with biochemical parameters of iron overload.	Iron	91-95	homeostatic iron regulator	Homo sapiens	12-15
12712916-2	2003	The aim of this study was to specify the relationship between iron overload, polymetabolic syndrome, HFE mutations of primary hemochromatosis and steatosis.	Iron	62-66	homeostatic iron regulator	Homo sapiens	101-104
12600215-8	2003	The present results are indicative of cleavage of the Fe-S bond in the nNOS mutants in their ferrous-NO state and imply a significant role of the conserved tryptophan in stabilization of the Fe-S bond.	Iron	54-56	nitric oxide synthase 1	Homo sapiens	71-75
9581927-6	1998	The relative fluorescence intensity at the Z-line decreased but that in the I-band increased gradually, showing the translocation of some titin FE-RE epitopes during the aging period.	Iron	144-146	titin	Bos taurus	138-143
12600215-8	2003	The present results are indicative of cleavage of the Fe-S bond in the nNOS mutants in their ferrous-NO state and imply a significant role of the conserved tryptophan in stabilization of the Fe-S bond.	Iron	191-193	nitric oxide synthase 1	Homo sapiens	71-75
12572667-0	2003	Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1.	Iron	0-4	aconitase 1	Homo sapiens	65-90
9566409-3	1998	This increase in serum transferrin receptor concentration before death suggests that the previously observed perturbation in iron metabolism continues throughout the disease course.	Iron	125-129	transferrin receptor	Homo sapiens	23-43
12572667-0	2003	Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1.	Iron	15-19	aconitase 1	Homo sapiens	65-90
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	23-27	Wnt family member 2	Homo sapiens	79-82
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	23-27	transferrin receptor	Homo sapiens	196-199
9516462-5	1998	Hypoxic inactivation of IRP1 was abolished when cells were pretreated with the iron chelator desferrioxamine, indicating a role for iron in inactivation.	Iron	79-83	aconitase 1	Rattus norvegicus	24-28
9516462-5	1998	Hypoxic inactivation of IRP1 was abolished when cells were pretreated with the iron chelator desferrioxamine, indicating a role for iron in inactivation.	Iron	132-136	aconitase 1	Rattus norvegicus	24-28
9516462-10	1998	Finally, reactivated IRP1 was found to be resistant to inactivation by exogenous iron known to down-regulate its activity during normoxia.	Iron	81-85	aconitase 1	Rattus norvegicus	21-25
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	120-124	Wnt family member 2	Homo sapiens	79-82
9515798-8	1998	In addition, treatment of cells with a soluble form of iron, 1.5 mM ferric ammonium citrate, resulted in an increase in mutation frequency at the gpt locus of approximately 1.5 fold above that of untreated G12 cells with no increase in mutations at the hgprt locus of V79 cells with ferric ammonium citrate.	Iron	55-59	glutamic--pyruvic transaminase	Homo sapiens	146-149
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	120-124	transferrin receptor	Homo sapiens	196-199
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	120-124	Wnt family member 2	Homo sapiens	79-82
12572667-2	2003	At the cellular level, iron homeostasis is accomplished by the activity of the IRP proteins, which, under conditions of iron depletion, up-regulate the expression of the iron acquisition proteins TfR and DMT1.	Iron	120-124	transferrin receptor	Homo sapiens	196-199
12572667-3	2003	It has been shown that hydrogen peroxide activates IRP1 and that this activation mediates a potentially harmful increase in cell iron uptake.	Iron	129-133	aconitase 1	Homo sapiens	51-55
9688217-0	1998	Iron binding and autoreduction by citrate: are these involved in signalling by iron regulatory protein-1?	Iron	0-4	aconitase 1	Homo sapiens	79-104
12572667-4	2003	Here we show that IRP1 activity is also induced by iron-mediated oxidative stress.	Iron	51-55	aconitase 1	Homo sapiens	18-22
12572667-5	2003	When cells were incubated with up to 20 microM of iron, a typical decrease in IRP1 and IRP2 activity was observed.	Iron	50-54	aconitase 1	Homo sapiens	78-82
12572667-11	2003	Increases in IRP1 activity were accompanied by increases in cell iron uptake, an indication that the activated IRP1 was functional in the activation of iron uptake.	Iron	65-69	aconitase 1	Homo sapiens	13-17
9510334-0	1998	Defining the orientation of the human U1A RBD1 on its UTR by tethered-EDTA(Fe) cleavage.	Iron	75-77	RNA, U1 small nuclear 1	Homo sapiens	38-46
12572667-11	2003	Increases in IRP1 activity were accompanied by increases in cell iron uptake, an indication that the activated IRP1 was functional in the activation of iron uptake.	Iron	65-69	aconitase 1	Homo sapiens	111-115
12572667-11	2003	Increases in IRP1 activity were accompanied by increases in cell iron uptake, an indication that the activated IRP1 was functional in the activation of iron uptake.	Iron	152-156	aconitase 1	Homo sapiens	13-17
12572667-11	2003	Increases in IRP1 activity were accompanied by increases in cell iron uptake, an indication that the activated IRP1 was functional in the activation of iron uptake.	Iron	152-156	aconitase 1	Homo sapiens	111-115
12572672-1	2003	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	transferrin receptor	Mus musculus	66-87
9466567-1	1998	Transferrin (Tf), a major transport protein for iron in the blood and an essential growth factor in some tissues, acts via specific transferrin receptor (TfR).	Iron	48-52	transferrin receptor	Homo sapiens	132-152
9466567-1	1998	Transferrin (Tf), a major transport protein for iron in the blood and an essential growth factor in some tissues, acts via specific transferrin receptor (TfR).	Iron	48-52	transferrin receptor	Homo sapiens	154-157
9466567-6	1998	In pituitaries with iron deposits, Tf and TfR were localized only in iron-free cells.	Iron	20-24	transferrin receptor	Homo sapiens	42-45
12572672-1	2003	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	transferrin receptor	Mus musculus	89-92
9466567-6	1998	In pituitaries with iron deposits, Tf and TfR were localized only in iron-free cells.	Iron	69-73	transferrin receptor	Homo sapiens	42-45
12572672-2	2003	Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin.	Iron	9-13	transferrin receptor	Mus musculus	83-86
12572672-3	2003	Moreover, NO*, a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels.	Iron	77-81	transferrin receptor	Mus musculus	150-153
12614226-3	2003	HFE mutations increase iron absorption in patients with haemochromatosis, and the mean transferrin saturations and ferritin levels are mildly increased in heterozygotes, suggesting that HFE mutations may protect against iron depletion and iron deficiency anaemia.	Iron	23-27	homeostatic iron regulator	Homo sapiens	0-3
12614226-3	2003	HFE mutations increase iron absorption in patients with haemochromatosis, and the mean transferrin saturations and ferritin levels are mildly increased in heterozygotes, suggesting that HFE mutations may protect against iron depletion and iron deficiency anaemia.	Iron	220-224	homeostatic iron regulator	Homo sapiens	0-3
9462661-8	1998	Six patients treated by phlebotomy to reduce hepatic iron and who were considered to be in clinical remission, characterized by a disappearance of cutaneous lesions, showed higher hepatic URO-D activities and lower hepatic porphyrin concentrations than did patients with overt PCT.	Iron	53-57	uroporphyrinogen decarboxylase	Homo sapiens	188-193
12779071-2	2003	Patients with hereditary hemochromatosis, a disease characterized by progressive iron overload due, in most cases, to homozygosity for C282Y mutation in the HFE gene, have often decreased insulin sensitivity and release.	Iron	81-85	homeostatic iron regulator	Homo sapiens	157-160
9422739-10	1998	The close relationship between iron acquisition and pathogenesis suggests that the release of iron from heme by heme oxygenase may play a crucial role in the pathogenicity of C. diphtheriae.	Iron	31-35	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	112-126
9422739-10	1998	The close relationship between iron acquisition and pathogenesis suggests that the release of iron from heme by heme oxygenase may play a crucial role in the pathogenicity of C. diphtheriae.	Iron	94-98	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	112-126
10730863-7	1998	We suggest that iron supplied as non-transferrin iron (ferric citrate) is apparently less available for the control of transferrin receptor expression via IRP activity than iron supplied as transferrin.	Iron	16-20	Wnt family member 2	Homo sapiens	155-158
12779071-3	2003	AIMS: To determine whether increased iron parameters/heterozygosity for the mutations of the HFE gene confer susceptibility to nonalcoholic fatty liver disease.	Iron	37-41	homeostatic iron regulator	Homo sapiens	93-96
12779071-10	2003	CONCLUSION: The mild iron overload associated with heterozygosity for C282Y HFE mutation confers susceptibility to nonalcoholic fatty liver disease, causing relative insulin deficiency.	Iron	21-25	homeostatic iron regulator	Homo sapiens	76-79
12673276-0	2003	A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism.	Iron	78-82	homeostatic iron regulator	Homo sapiens	46-49
9425935-2	1998	Mild to moderate iron overload is common in PCT, as iron is one of the factors which trigger the clinical manifestations of the disease through the inactivation of URO-D.	Iron	17-21	uroporphyrinogen decarboxylase	Homo sapiens	164-169
9425935-2	1998	Mild to moderate iron overload is common in PCT, as iron is one of the factors which trigger the clinical manifestations of the disease through the inactivation of URO-D.	Iron	52-56	uroporphyrinogen decarboxylase	Homo sapiens	164-169
12673276-10	2003	The HFE gene explained about 5% of the variability in serum iron indices.	Iron	60-64	homeostatic iron regulator	Homo sapiens	4-7
9396727-1	1997	Control of cellular iron homoeostasis is performed by iron regulatory protein 1 (IRP1) through post-transcriptional modifications.	Iron	20-24	aconitase 1	Homo sapiens	54-79
9396727-1	1997	Control of cellular iron homoeostasis is performed by iron regulatory protein 1 (IRP1) through post-transcriptional modifications.	Iron	20-24	aconitase 1	Homo sapiens	81-85
12673276-14	2003	Our study shows that the HFE C282Y and H63D are determinants of iron parameters in the elderly and will be effective in detecting individuals at high risk of hemochromatosis.	Iron	64-68	homeostatic iron regulator	Homo sapiens	25-28
9396727-8	1997	We surmise that ALA-induced IRP1 activation might act as a co-sensor of iron homoeostasis.	Iron	72-76	aconitase 1	Homo sapiens	28-32
12584213-7	2003	Reduced absorption was also accompanied by a rapid decrease in expression of the mRNAs encoding the brush border iron transport molecules Dcytb and the iron responsive element (IRE) containing the splice variant of DMT1.	Iron	113-117	cytochrome b reductase 1	Rattus norvegicus	138-143
12657433-0	2003	The enigmatic role of the hemochromatosis protein (HFE) in iron absorption.	Iron	59-63	homeostatic iron regulator	Homo sapiens	51-54
12388178-9	2003	Rats fed FE developed fatty liver, necrosis, and inflammation, which was accompanied by activation of NF-kappaB and the induction of cytokines, chemokines, COX-2, iNOS, and nitrotyrosine formation.	Iron	9-11	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	156-161
9434348-4	1997	In this study we demonstrate that proteins encoded by genes previously demonstrated to play critical roles in vacuole assembly for acidification, PEP3, PEP5 and VMA3, are also required for normal copper and iron metal ion homeostasis.	Iron	207-211	tethering complex subunit PEP3	Saccharomyces cerevisiae S288C	146-150
9434348-5	1997	Yeast cells lacking a functional PEP3 or PEP5 gene are hypersensitive to copper and render the normally iron-repressible FET3 gene, encoding a multi-copper Fe(II) oxidase involved in Fe2+ transport, also repressible by exogenous copper ions.	Iron	104-108	tethering complex subunit PEP3	Saccharomyces cerevisiae S288C	33-37
12608731-0	2003	Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats.	Iron	81-85	transferrin receptor	Rattus norvegicus	35-55
9398517-1	1997	The iron responsive element (IRE) is a approximately 30 nucleotide RNA hairpin that is located in the 5" untranslated region of all ferritin mRNAs and in the 3" untranslated region of all transferrin receptor mRNAs.	Iron	4-8	transferrin receptor	Homo sapiens	188-208
12608731-1	2003	The mechanism of the regulation of transferrin (Tf) and transferrin receptor (TfR) levels in rat brain by dietary iron status is not fully elucidated.	Iron	114-118	transferrin receptor	Rattus norvegicus	56-76
9398517-2	1997	The IREs are bound by two related IRE-binding proteins (IRPs) which help control intracellular levels of iron by regulating the expression of both ferritin and transferrin receptor genes.	Iron	105-109	transferrin receptor	Homo sapiens	160-180
12608731-1	2003	The mechanism of the regulation of transferrin (Tf) and transferrin receptor (TfR) levels in rat brain by dietary iron status is not fully elucidated.	Iron	114-118	transferrin receptor	Rattus norvegicus	78-81
12608731-3	2003	In a region-specific fashion, iron-deficient diet decreased significantly brain iron concentration by 22-63%, and increased Tf level by 22-130% and TfR level by 74% in thalamus and 40% in cortex.	Iron	30-34	transferrin receptor	Rattus norvegicus	148-151
12522121-0	2003	Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis.	Iron	25-29	transferrin receptor	Homo sapiens	148-168
9362508-2	1997	SFT-mediated transport has properties defined for transferrin-independent Fe uptake, but its cytolocalization in recycling endosomes and the observed stimulation of transferrin-bound Fe assimilation indicate a key role in intracellular Fe membrane transport as well.	Iron	183-185	transferrin S homeolog	Xenopus laevis	165-176
9362508-2	1997	SFT-mediated transport has properties defined for transferrin-independent Fe uptake, but its cytolocalization in recycling endosomes and the observed stimulation of transferrin-bound Fe assimilation indicate a key role in intracellular Fe membrane transport as well.	Iron	183-185	transferrin S homeolog	Xenopus laevis	165-176
12522121-0	2003	Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis.	Iron	179-183	transferrin receptor	Homo sapiens	148-168
12522121-2	2003	In this study, we report that H2O2-dependent intracellular oxidation of DCFH to a green fluorescent product, 2",7"-dichlorofluorescein (DCF), required the uptake of extracellular iron transported through a transferrin receptor (TfR) in endothelial cells.	Iron	179-183	transferrin receptor	Homo sapiens	206-226
12522121-2	2003	In this study, we report that H2O2-dependent intracellular oxidation of DCFH to a green fluorescent product, 2",7"-dichlorofluorescein (DCF), required the uptake of extracellular iron transported through a transferrin receptor (TfR) in endothelial cells.	Iron	179-183	transferrin receptor	Homo sapiens	228-231
12522121-3	2003	H2O2-induced DCF fluorescence was inhibited by the monoclonal IgA-class anti-TfR antibody (42/6) that blocked TfR endocytosis and the iron uptake.	Iron	134-138	transferrin receptor	Homo sapiens	77-80
9353309-8	1997	Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells.	Iron	29-33	Mmt2p	Saccharomyces cerevisiae S288C	92-96
12461085-0	2002	Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis.	Iron	18-22	beta-2 microglobulin	Mus musculus	42-62
9353309-8	1997	Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells.	Iron	52-56	Mmt2p	Saccharomyces cerevisiae S288C	92-96
9353309-8	1997	Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells.	Iron	52-56	Mmt2p	Saccharomyces cerevisiae S288C	92-96
9367630-3	1997	First, we examine the role of mRNA half-life, by studying the distribution of the mRNA for the transferrin receptor (TfR), whose half-life can be manipulated in culture by changing the availability of iron.	Iron	201-205	transferrin receptor	Mus musculus	95-115
9367630-3	1997	First, we examine the role of mRNA half-life, by studying the distribution of the mRNA for the transferrin receptor (TfR), whose half-life can be manipulated in culture by changing the availability of iron.	Iron	201-205	transferrin receptor	Mus musculus	117-120
12461085-5	2002	Accordingly, beta2m-deficient mice suffer from tissue iron overload.	Iron	54-58	beta-2 microglobulin	Mus musculus	13-19
12461085-6	2002	Here, we show that modulating the extracellular iron pool in beta2m-KO mice by lactoferrin treatment significantly reduces the burden of M. tuberculosis to numbers comparable to those observed in MHC class I-KO mice.	Iron	48-52	beta-2 microglobulin	Mus musculus	61-67
9413439-0	1997	The yeast FET5 gene encodes a FET3-related multicopper oxidase implicated in iron transport.	Iron	77-81	ferroxidase FET3	Saccharomyces cerevisiae S288C	30-34
12461085-10	2002	Our data establish: (a) defective iron metabolism explains the increased susceptibility of beta2m-KO mice over MHC-I-KO mice, and (b) iron overload represents an exacerbating cofactor for tuberculosis.	Iron	34-38	beta-2 microglobulin	Mus musculus	91-97
9413439-1	1997	The yeast FET3 gene encodes an integral membrane multicopper oxidase required for high-affinity iron uptake.	Iron	96-100	ferroxidase FET3	Saccharomyces cerevisiae S288C	10-14
9413439-3	1997	To identify other yeast genes involved in iron uptake, we isolated genes that could, when overexpressed, suppress the iron-limited growth defect of a fet3 fet4 mutant.	Iron	42-46	ferroxidase FET3	Saccharomyces cerevisiae S288C	150-154
12388055-9	2002	Our data show that XOR activity is transcriptionally induced by iron but posttranslationally inactivated by iron chelation.	Iron	64-68	xanthine dehydrogenase	Homo sapiens	19-22
9413439-3	1997	To identify other yeast genes involved in iron uptake, we isolated genes that could, when overexpressed, suppress the iron-limited growth defect of a fet3 fet4 mutant.	Iron	118-122	ferroxidase FET3	Saccharomyces cerevisiae S288C	150-154
9413439-5	1997	Several observations indicate that Fet5p plays a role analogous to Fet3p in iron transport.	Iron	76-80	ferroxidase FET3	Saccharomyces cerevisiae S288C	67-72
12388055-9	2002	Our data show that XOR activity is transcriptionally induced by iron but posttranslationally inactivated by iron chelation.	Iron	108-112	xanthine dehydrogenase	Homo sapiens	19-22
12775112-8	2002	Regardless of the dietary zinc level, rats fed diets with an Fe concentration of 2 microg/g had decreased zinc absorption and plasma ALK-P activity.	Iron	61-63	ALK receptor tyrosine kinase	Rattus norvegicus	133-136
9409707-0	1997	Involvement of iron in MPP+ toxicity in substantia nigra: protection by desferrioxamine.	Iron	15-19	M-phase phosphoprotein 6	Homo sapiens	23-26
9409707-6	1997	The ability of DES to protect against MPP+ toxicity may indicate a therapeutic strategy in the treatment of diseases when iron is implicated.	Iron	122-126	M-phase phosphoprotein 6	Homo sapiens	38-41
12578113-14	2002	Iron from the CFA particles was responsible for inducing the iron-storage protein ferritin in cultured human lung epithelial cells (A549 cells).	Iron	0-4	Ferritin 1 heavy chain homologue	Drosophila melanogaster	82-90
9393640-4	1997	After import in vitro into mitochondria isolated from a cytochrome b-deficient yeast strain, the mutants lacking residues 41-55 and 182-196 were assembled as efficiently as the wild type; however, the mutants lacking residues 55-66 and 66-78 were assembled less efficiently in the absence of cytochrome b suggesting that the hydrophobic membrane-spanning region, residues 55-78, of the iron-sulfur protein, may interact with cytochrome b during the assembly of the bc1 complex.	Iron	386-390	cytochrome b	Saccharomyces cerevisiae S288C	56-68
9380695-2	1997	IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs.	Iron	14-18	transferrin receptor	Mus musculus	129-149
9380695-2	1997	IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs.	Iron	14-18	transferrin receptor	Mus musculus	151-154
9380695-2	1997	IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs.	Iron	44-48	transferrin receptor	Mus musculus	129-149
9380695-2	1997	IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs.	Iron	44-48	transferrin receptor	Mus musculus	151-154
12578113-15	2002	The amount of iron mobilized by citrate was directly proportional to the amount of ferritin induced in the A549 cells.	Iron	14-18	Ferritin 1 heavy chain homologue	Drosophila melanogaster	83-91
9380695-9	1997	In the Ba/F3 family of cells, alterations in iron status modulated ferritin biosynthesis and TfR mRNA level over as much as a 20- and 14-fold range, respectively.	Iron	45-49	transferrin receptor	Mus musculus	93-96
12578113-17	2002	Iron existed in several species in the fly ash, but the bioavailable iron was associated with the glassy aluminosilicate fraction, which caused ferritin and IL-8 to be induced in the A549 cells.	Iron	69-73	Ferritin 1 heavy chain homologue	Drosophila melanogaster	144-152
12198135-1	2002	Iron-responsive elements (IREs) are the RNA stem loops that control cellular iron homeostasis by regulating ferritin translation and transferrin receptor mRNA stability.	Iron	0-4	transferrin receptor	Homo sapiens	133-153
9312270-10	1997	Thus supplying a single electron from NADPH to the heme iron permits nNOS to catalyze one full round of citrulline and NO synthesis from NOHA upon exposure to O2.	Iron	56-60	nitric oxide synthase 1	Homo sapiens	69-73
9316467-1	1997	Expression of transferrin receptor and ferritin genes has been shown previously to be under transcriptional and posttranscriptional regulation, the latter being reciprocally regulated according to cellular iron levels.	Iron	206-210	transferrin receptor	Rattus norvegicus	14-34
12198135-1	2002	Iron-responsive elements (IREs) are the RNA stem loops that control cellular iron homeostasis by regulating ferritin translation and transferrin receptor mRNA stability.	Iron	77-81	transferrin receptor	Homo sapiens	133-153
12431098-2	2002	Binding of NO to the heme iron of the NT-HBD of HRI activates its eIF2alpha kinase activity, thus inhibiting the initiation of translation in reticulocyte lysate.	Iron	26-30	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	48-51
9400737-8	1997	Treatment of cells with crocidolite pretreated with the iron chelator desferrioxamine B resulted in the same level of intracellular GSH depletion and efflux and the same decrease in gamma-GCS activity as treatment with unmodified crocidolite, which suggests that iron-catalyzed reactions were not responsible for the GSH depletion.	Iron	56-60	glutamate-cysteine ligase catalytic subunit	Homo sapiens	182-191
12431098-6	2002	As evidenced by the resonance Raman spectra, two inactive forms of HRI, the ferrous ligand-unbound and the CO-bound states of the NT-HBD, contain a six-coordinate complex as found for the NO complex, indicating that the replacement of the sixth ligand of the heme iron is not sufficient to trigger the activation of HRI.	Iron	264-268	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	67-70
9338146-0	1997	The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein (IRP).	Iron	38-42	Wnt family member 2	Homo sapiens	113-116
9338146-6	1997	We demonstrated that the activity (ratio activated/total) of the iron regulatory protein (IRP) in HID cells Jiyoye and K562 increased more than twofold (from 0.32 to 0.79 and from 0.47 to 1.12, respectively) within 48 h after their transfer into low-iron medium.	Iron	65-69	Wnt family member 2	Homo sapiens	90-93
9338146-8	1997	Addition of iron chelator deferoxamine (50 microM, i.e., about half-maximal growth-inhibitory dose) resulted in significantly increased activity of IRP also in HeLa and THP-1 cells.	Iron	12-16	Wnt family member 2	Homo sapiens	148-151
12439744-1	2002	High expression of transferrin receptor (TfR) on the membrane of erythroid cells accounts for the high level of iron required to sustain heme synthesis.	Iron	112-116	transferrin receptor	Homo sapiens	19-39
9242665-1	1997	Expression of several proteins of higher eukaryotes is post-transcriptionally regulated by interaction of iron-responsive elements (IREs) on their mRNAs and iron regulatory proteins (IRP1 and IRP2).	Iron	106-110	aconitase 1	Homo sapiens	183-187
9242665-2	1997	IRP1 is a redox-sensitive iron-sulfur protein whose regulatory activity is modulated by iron depletion, synthesis of nitric oxide, or oxidative stress.	Iron	26-30	aconitase 1	Homo sapiens	0-4
9242665-2	1997	IRP1 is a redox-sensitive iron-sulfur protein whose regulatory activity is modulated by iron depletion, synthesis of nitric oxide, or oxidative stress.	Iron	88-92	aconitase 1	Homo sapiens	0-4
9242665-9	1997	Substrates of aconitase, which bind to the cluster of IRP1, prevented this effect, pointing to the [Fe-S] cluster as the target of peroxynitrite.	Iron	100-104	aconitase 1	Homo sapiens	54-58
12439744-1	2002	High expression of transferrin receptor (TfR) on the membrane of erythroid cells accounts for the high level of iron required to sustain heme synthesis.	Iron	112-116	transferrin receptor	Homo sapiens	41-44
12397016-0	2002	Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts.	Iron	21-25	jun proto-oncogene	Mus musculus	61-99
9266686-1	1997	Ferritin was purified from iron-fed Drosophila melanogaster extracts by centrifugation in a gradient of potassium bromide.	Iron	27-31	Ferritin 1 heavy chain homologue	Drosophila melanogaster	0-8
12397016-9	2002	We have found that iron transactivated both AP-1 and NFAT, and DFO further enhanced iron-induced AP-1 activation but inhibited NFAT.	Iron	19-23	jun proto-oncogene	Mus musculus	44-48
12397016-9	2002	We have found that iron transactivated both AP-1 and NFAT, and DFO further enhanced iron-induced AP-1 activation but inhibited NFAT.	Iron	84-88	jun proto-oncogene	Mus musculus	97-101
9210649-1	1997	Ferritin mRNAs are translationally regulated by the binding of either of two cytosolic proteins, iron regulatory protein 1 (IRP1) or IRP2, to the iron responsive element (IRE) located in their 5" untranslated region (UTR).	Iron	97-101	aconitase 1	Rattus norvegicus	124-128
12397016-10	2002	These results indicate that activation of AP-1 and NFAT by the PA coal is through bioavailable iron present in the coal.	Iron	95-99	jun proto-oncogene	Mus musculus	42-46
12547214-1	2002	HFE-associated hereditary hemochromatosis is characterized by imbalances of iron homeostasis and alterations in intestinal iron absorption.	Iron	76-80	homeostatic iron regulator	Homo sapiens	0-3
9237628-1	1997	In plants, only ferritin gene expression has been reported to be iron-dependent.	Iron	65-69	ferritin-1, chloroplastic	Brassica napus	16-24
12547214-1	2002	HFE-associated hereditary hemochromatosis is characterized by imbalances of iron homeostasis and alterations in intestinal iron absorption.	Iron	123-127	homeostatic iron regulator	Homo sapiens	0-3
12547221-2	2002	Iron regulatory proteins 1 and 2 are cytosolic proteins that bind to RNA stem-loops known as iron-responsive elements in several transcripts.	Iron	93-97	aconitase 1	Homo sapiens	0-32
12547224-8	2002	In the iron deficient gut, large quantities of both mobilferrin and DMT-1 are found in goblet cells and intraluminal mucins suggesting that they are secreted with mucin into the intestinal lumen to bind iron to facilitate uptake by the cells.	Iron	7-11	LOC100508689	Homo sapiens	117-122
12425487-2	2002	Soluble transferrin receptor (sTfR) has caught the attention of physicians recently as regards its use as a parameter for the evaluation of iron status.	Iron	140-144	transferrin receptor	Homo sapiens	8-28
9162052-1	1997	The FET3 gene product of Saccharomyces cerevisiae is an essential component of the high affinity iron transport system.	Iron	97-101	ferroxidase FET3	Saccharomyces cerevisiae S288C	4-8
9162052-9	1997	Purified Fet3p is a copper-containing protein that is able to catalyze the oxidation of a variety of organic compounds in addition to ferrous iron.	Iron	142-146	ferroxidase FET3	Saccharomyces cerevisiae S288C	9-14
9162052-12	1997	Interestingly, Fet3p was able to effectively catalyze the incorporation of iron onto apotransferrin.	Iron	75-79	ferroxidase FET3	Saccharomyces cerevisiae S288C	15-20
12425487-3	2002	This study was conducted in order to evaluate the correlation of serum soluble transferrin receptor (sTfR) concentration with hematological parameters and iron profiles, in the role of identifying iron deficiency among dialysis patients.	Iron	155-159	transferrin receptor	Homo sapiens	79-99
16120311-4	2002	Frataxin may be a mitochondrial iron-binding protein that prevents this metal from participating in Fenton chemistry to generate toxic hydroxyl radicals.	Iron	32-36	frataxin	Homo sapiens	0-8
9169016-0	1997	Loading of iron into recombinant rat liver ferritin heteropolymers by ceruloplasmin.	Iron	11-15	ceruloplasmin	Rattus norvegicus	70-83
12417917-3	2002	IRP binding to IRE is regulated by cellular iron.	Iron	44-48	Wnt family member 2	Homo sapiens	0-3
11669832-6	1997	The 10.8 Hz coupling between (57)Fe and the hydride in [(eta(6)-toluene)Fe(H)(SiCl(3))(2)](-) and (eta(6)-toluene)Fe(H)(py)(SiCl(3)) is similar to those observed in other Fe(II) hydrido compounds.	Iron	33-35	endothelin receptor type A	Homo sapiens	57-60
11669832-6	1997	The 10.8 Hz coupling between (57)Fe and the hydride in [(eta(6)-toluene)Fe(H)(SiCl(3))(2)](-) and (eta(6)-toluene)Fe(H)(py)(SiCl(3)) is similar to those observed in other Fe(II) hydrido compounds.	Iron	33-35	endothelin receptor type A	Homo sapiens	99-102
9168799-12	1997	Thus, heme-hemopexin not only functions as an iron source for T-cells but occupancy of the hemopexin receptor itself triggers signaling pathway(s) involved in the regulation of cell growth.	Iron	46-50	hemopexin	Homo sapiens	11-20
12417917-4	2002	When cells are derived of iron, IRP binds IRE.	Iron	26-30	Wnt family member 2	Homo sapiens	32-35
12417917-9	2002	IRE-IRP binding is involved in the regulation of iron metabolism, oxidative stress and possibly aging.	Iron	49-53	Wnt family member 2	Homo sapiens	4-7
12379078-0	2002	The effect of HFE genotypes on measurements of iron overload.	Iron	47-51	homeostatic iron regulator	Homo sapiens	14-17
9144784-1	1997	The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae is a divalent-metal activated repressor of chromosomal genes responsible for siderophore-mediated iron-uptake and of a gene on several corynebacteriophages that encodes diphtheria toxin.	Iron	169-173	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
9144784-1	1997	The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae is a divalent-metal activated repressor of chromosomal genes responsible for siderophore-mediated iron-uptake and of a gene on several corynebacteriophages that encodes diphtheria toxin.	Iron	169-173	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
9144784-2	1997	Even though DtxR is the best characterized iron-dependent repressor to date, numerous key properties of the protein still remain to be explained.	Iron	43-47	MarR family transcriptional regulator	Corynebacterium diphtheriae	12-16
12270831-7	2002	The mutant containing the transposon insertion within dtxR does not produce DtxR and overproduces siderophore in the presence of iron.	Iron	129-133	MarR family transcriptional regulator	Corynebacterium diphtheriae	54-58
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	48-52	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	162-166
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	48-52	ferroxidase FET3	Saccharomyces cerevisiae S288C	171-175
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	110-114	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	162-166
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	110-114	ferroxidase FET3	Saccharomyces cerevisiae S288C	171-175
12849398-5	2002	Frataxin is involved in iron metabolism and may protect mitochondria from oxidative damage.	Iron	24-28	frataxin	Homo sapiens	0-8
9092825-0	1997	The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites.	Iron	4-8	aconitase 1	Homo sapiens	27-52
9092825-1	1997	Iron regulatory protein 1 (IRP1) modulates iron metabolism by binding to mRNAs encoding proteins involved in the uptake, storage, and metabolic utilization of iron.	Iron	43-47	aconitase 1	Homo sapiens	0-25
9092825-1	1997	Iron regulatory protein 1 (IRP1) modulates iron metabolism by binding to mRNAs encoding proteins involved in the uptake, storage, and metabolic utilization of iron.	Iron	43-47	aconitase 1	Homo sapiens	27-31
9092825-1	1997	Iron regulatory protein 1 (IRP1) modulates iron metabolism by binding to mRNAs encoding proteins involved in the uptake, storage, and metabolic utilization of iron.	Iron	159-163	aconitase 1	Homo sapiens	0-25
12382198-4	2002	Wild-type HFE protein binds to the transferrin receptor, and by an undefined mechanism the enterocyte is "programmed" to absorb an amount of dietary iron precisely matched to the body"s needs.	Iron	149-153	homeostatic iron regulator	Homo sapiens	10-13
9092825-1	1997	Iron regulatory protein 1 (IRP1) modulates iron metabolism by binding to mRNAs encoding proteins involved in the uptake, storage, and metabolic utilization of iron.	Iron	159-163	aconitase 1	Homo sapiens	27-31
9092825-2	1997	Iron regulates IRP1 function by promoting assembly of an iron-sulfur cluster in the apo or RNA binding form, thereby converting it to the active holo or cytoplasmic aconitase form.	Iron	0-4	aconitase 1	Homo sapiens	15-19
9092825-2	1997	Iron regulates IRP1 function by promoting assembly of an iron-sulfur cluster in the apo or RNA binding form, thereby converting it to the active holo or cytoplasmic aconitase form.	Iron	57-61	aconitase 1	Homo sapiens	15-19
12382200-21	2002	Frataxin appears to regulate mitochondrial iron (or iron-sulfur cluster) export and the neurologic and cardiac manifestations of Friedreich ataxia are due to iron-mediated mitochondrial toxicity.	Iron	43-47	frataxin	Homo sapiens	0-8
12382200-21	2002	Frataxin appears to regulate mitochondrial iron (or iron-sulfur cluster) export and the neurologic and cardiac manifestations of Friedreich ataxia are due to iron-mediated mitochondrial toxicity.	Iron	52-56	frataxin	Homo sapiens	0-8
12382200-21	2002	Frataxin appears to regulate mitochondrial iron (or iron-sulfur cluster) export and the neurologic and cardiac manifestations of Friedreich ataxia are due to iron-mediated mitochondrial toxicity.	Iron	52-56	frataxin	Homo sapiens	0-8
9325434-13	1997	Interestingly, recent work has suggested that the short-lived messenger molecule, NO (or its by-product, peroxynitrite), can affect cellular Fe metabolism via its interaction with IRP1.	Iron	141-143	aconitase 1	Homo sapiens	180-184
12382201-8	2002	These studies indicate that the possible defect is different from mutations in the HFE gene frequently found in Caucasians with iron overload, but the putative gene has not been identified.	Iron	128-132	homeostatic iron regulator	Homo sapiens	83-86
12382201-9	2002	Recent studies also indicate that non-HFE iron overload occurs in African-Americans, but the prevalence and possible genetic basis is yet to be determined.	Iron	42-46	homeostatic iron regulator	Homo sapiens	38-41
12237228-5	2002	Protoporphyrin IX compounds where the native Fe was substituted with Zn, Mn, Co, or Sn lead to assembly of nNOS, but no detectable NO was synthesized in the presence of NADPH and L-arginine.	Iron	45-47	nitric oxide synthase 1	Homo sapiens	107-111
9073575-2	1997	More specifically, the activity of two [Fe-S] enzymes was followed during the course of NO synthase expression:mitochondrial aconitase, which catalyzes citrate:isocitrate conversion in the Krebs cycle, and cytoplasmic aconitase, or iron regulatory protein (IRP), a trans-regulator that controls expression at the posttranscriptional level of proteins involved in iron metabolism.	Iron	40-44	Wnt family member 2	Homo sapiens	232-255
9073575-2	1997	More specifically, the activity of two [Fe-S] enzymes was followed during the course of NO synthase expression:mitochondrial aconitase, which catalyzes citrate:isocitrate conversion in the Krebs cycle, and cytoplasmic aconitase, or iron regulatory protein (IRP), a trans-regulator that controls expression at the posttranscriptional level of proteins involved in iron metabolism.	Iron	40-44	Wnt family member 2	Homo sapiens	257-260
12209011-1	2002	Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor.	Iron	109-113	transferrin receptor	Homo sapiens	179-199
9028338-1	1997	The objective of the study was to evaluate the diagnostic efficiency of laboratory tests, including serum transferrin receptor (TfR) measurements, in the diagnosis of iron depletion.	Iron	167-171	transferrin receptor	Homo sapiens	106-126
9028338-1	1997	The objective of the study was to evaluate the diagnostic efficiency of laboratory tests, including serum transferrin receptor (TfR) measurements, in the diagnosis of iron depletion.	Iron	167-171	transferrin receptor	Homo sapiens	128-131
12209011-5	2002	Here, we show that iron regulation of DMT1 involves the expression of a previously unrecognized upstream 5" exon (exon 1A) of the human and murine DMT1 gene.	Iron	19-23	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	147-151
9028338-11	1997	In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.	Iron	88-92	transferrin receptor	Homo sapiens	20-23
9028338-11	1997	In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.	Iron	208-212	transferrin receptor	Homo sapiens	20-23
12169576-1	2002	The iron chelator deferoxamine has been reported to inhibit both xanthine oxidase (XO) and xanthine dehydrogenase activity, but the relationship of this effect to the availability of iron in the cellular and tissue environment remains unexplored.	Iron	4-8	xanthine dehydrogenase	Rattus norvegicus	91-113
9127455-0	1997	Components of biological variation in serum soluble transferrin receptor: relationships to serum iron, transferrin and ferritin concentrations, and immune and haematological variables.	Iron	97-101	transferrin receptor	Homo sapiens	52-72
9127455-6	1997	Up to 34.2% of the within-subject variability in TfR (which reflects changes over time) could be explained by the regression on iron, ferritin, Tf, sIL-2R, sIL-6R and MCH values.	Iron	128-132	transferrin receptor	Homo sapiens	49-52
9127455-7	1997	Up to 67.2% of the between-subject variability in TfR (which reflects differences in the homeostatic setpoint during the study year) could be explained by the regression on gender, iron, Tf, and ferritin values.	Iron	181-185	transferrin receptor	Homo sapiens	50-53
12169576-3	2002	Lung XO and total xanthine oxidoreductase activities were reduced in rats fed an iron-depleted diet and increased in rats supplemented with iron, without change in the ratio of XO to total oxidoreductase.	Iron	81-85	xanthine dehydrogenase	Rattus norvegicus	18-41
12169576-3	2002	Lung XO and total xanthine oxidoreductase activities were reduced in rats fed an iron-depleted diet and increased in rats supplemented with iron, without change in the ratio of XO to total oxidoreductase.	Iron	140-144	xanthine dehydrogenase	Rattus norvegicus	18-41
12169576-4	2002	Intratracheal injection of an iron salt or silica-iron, but not aluminum salts or silica-zinc, significantly increased rat lung XO and total xanthine oxidoreductase activities, immunoreactive xanthine oxidoreductase, and the concentration of urate in bronchoalveolar fluid.	Iron	30-34	xanthine dehydrogenase	Rattus norvegicus	141-164
9020769-6	1997	Analysis of the deduced amino acid sequences of SCR1 and SCR2 suggests that S. cerevisiae possesses two similar enzymes encoded on separate chromosomes: one which bears an Fe-S binding motif, while the other does not.	Iron	172-176	SCR1	Saccharomyces cerevisiae S288C	48-52
9020769-6	1997	Analysis of the deduced amino acid sequences of SCR1 and SCR2 suggests that S. cerevisiae possesses two similar enzymes encoded on separate chromosomes: one which bears an Fe-S binding motif, while the other does not.	Iron	172-176	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	57-61
12169576-4	2002	Intratracheal injection of an iron salt or silica-iron, but not aluminum salts or silica-zinc, significantly increased rat lung XO and total xanthine oxidoreductase activities, immunoreactive xanthine oxidoreductase, and the concentration of urate in bronchoalveolar fluid.	Iron	30-34	xanthine dehydrogenase	Rattus norvegicus	192-215
12181184-0	2002	Effect of iron status on DMT1 expression in duodenal enterocytes from beta2-microglobulin knockout mice.	Iron	10-14	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	25-29
9003447-0	1997	Role of the O-phosphoserine clusters in the interaction of the bovine milk alpha s1-, beta-, kappa-caseins and the PP3 component with immobilized iron (III) ions.	Iron	146-150	glycosylation dependent cell adhesion molecule 1	Bos taurus	115-118
12181184-1	2002	Divalent metal transporter I (DMT1) is thought to be involved in transport of iron across the apical cell membrane of villus duodenal cells.	Iron	78-82	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	30-34
12181184-8	2002	DMT1 expression was increased to the same extent in B2M+/+ and B2M-/- mice when fed an iron-poor diet.	Iron	87-91	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	0-4
12181184-9	2002	In both strains of mice fed an iron-poor diet, DMT1 was evenly distributed in the differentiated enterocytes from the base to the tip of the villi but was absent from the crypts of Lieberkuhn.	Iron	31-35	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	47-51
9192174-5	1997	Iron regulatory proteins are regulated either by assembly or by disassembly of an iron-sulfur cluster (IRP1) or by rapid degradation in the presence of iron (IRP2).	Iron	0-4	aconitase 1	Homo sapiens	103-107
9192174-5	1997	Iron regulatory proteins are regulated either by assembly or by disassembly of an iron-sulfur cluster (IRP1) or by rapid degradation in the presence of iron (IRP2).	Iron	82-86	aconitase 1	Homo sapiens	103-107
12169610-0	2002	Identification of a DtxR-regulated operon that is essential for siderophore-dependent iron uptake in Corynebacterium diphtheriae.	Iron	86-90	MarR family transcriptional regulator	Corynebacterium diphtheriae	20-24
9503598-4	1997	The ranges of SCP under the influence of temperature, light, nitrate, ammonia, phosphorus, iron, carbonate, and sodium chloride were in the following respective order (% dry wt): 18.4-43.3, 20.5-42.3, 12.4-35.8, 15.7-41.8, 15.8-49.4, 17.4-49.7, 13.8-35.6, and 0.0-37.7.	Iron	91-95	solute carrier family 50 member 1	Homo sapiens	14-17
12169610-1	2002	The diphtheria toxin repressor (DtxR) uses Fe(2+) as a corepressor and inhibits transcription from iron-regulated promoters (IRPs) in Corynebacterium diphtheriae.	Iron	99-103	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
12169610-1	2002	The diphtheria toxin repressor (DtxR) uses Fe(2+) as a corepressor and inhibits transcription from iron-regulated promoters (IRPs) in Corynebacterium diphtheriae.	Iron	99-103	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
12169610-3	2002	DtxR bound to IRP6 in vitro only in the presence of appropriate divalent metal ions, and repression of IRP6 by DtxR in an Escherichia coli system was iron dependent.	Iron	150-154	MarR family transcriptional regulator	Corynebacterium diphtheriae	111-115
12130528-4	2002	The goal of this study was to perform a mutational analysis of the TfR2 and HFE genes in a cohort of non-C282Y iron overload patients of mixed ethnic backgrounds.	Iron	111-115	homeostatic iron regulator	Homo sapiens	76-79
9296456-5	1997	On the other hand, the induction of a cellular prooxidative condition activates the protein IRP (iron regulatory protein) in a way that renders the cell more able to take up iron.	Iron	97-101	Wnt family member 2	Homo sapiens	92-95
8977218-6	1997	The mRNA levels for the membrane receptor for iron uptake, transferrin receptor (TfR), decrease following stimulation with IFN-gamma/LPS, although IRP-mediated stabilization of the TfR mRNA would have been expected.	Iron	46-50	transferrin receptor	Mus musculus	59-79
8977218-6	1997	The mRNA levels for the membrane receptor for iron uptake, transferrin receptor (TfR), decrease following stimulation with IFN-gamma/LPS, although IRP-mediated stabilization of the TfR mRNA would have been expected.	Iron	46-50	wingless-type MMTV integration site family, member 2	Mus musculus	147-150
8977218-8	1997	Thus, IL-4 and IL-13 regulate the iron metabolism of activated macrophages by at least two different pathways: first, by opposing NO-mediated IRP activation, thereby increasing ferritin translation; and second, by an IRP-independent augmentation of TfR mRNA expression.	Iron	34-38	wingless-type MMTV integration site family, member 2	Mus musculus	217-220
12139757-5	2002	The underlying mechanism was an effect of EPO on e-ALAS mRNA translation, which was under the control of iron regulatory proteins (IRP) 1 and 2.	Iron	105-109	aconitase 1	Homo sapiens	131-143
9812635-3	1997	Levels of TfR-mRNA also increased with decrease of iron in substrate.	Iron	51-55	transferrin receptor	Homo sapiens	10-13
9812635-4	1997	Iron concentration within cells correlated inversely to the change in the number of TfR.	Iron	0-4	transferrin receptor	Homo sapiens	84-87
12196404-1	2002	The HFE locus encodes an HLA class-I-type protein important in iron regulation and segregates replacement mutations that give rise to the most common form of genetic hemochromatosis.	Iron	63-67	homeostatic iron regulator	Homo sapiens	4-7
8955074-7	1996	In the absence of L-arginine, NOS-1 catalyzed simple O2 reduction, and its heme iron displayed a typical affinity for O2 (estimated KmO2 &lt;/= 40 microM, saturation at approximately 100 microM).	Iron	80-84	nitric oxide synthase 1	Homo sapiens	30-35
12140189-2	2002	At the biochemical level, the lack of frataxin leads to dysregulation of mitochondrial iron homeostasis and oxidative damage, which eventually causes neuronal death.	Iron	87-91	frataxin	Homo sapiens	38-46
8961933-3	1996	Although IRP1 and IRP2 are similar proteins in that they are ubiquitously expressed and are negatively regulated by iron, they are regulated by iron by different mechanisms.	Iron	116-120	aconitase 1	Rattus norvegicus	9-13
8961933-3	1996	Although IRP1 and IRP2 are similar proteins in that they are ubiquitously expressed and are negatively regulated by iron, they are regulated by iron by different mechanisms.	Iron	144-148	aconitase 1	Rattus norvegicus	9-13
8961933-4	1996	IRP1, the well-characterized IRP in cells, is a dual-function protein exhibiting either aconitase activity when cellular iron is abundant or RNA-binding activity when cellular iron is scarce.	Iron	121-125	aconitase 1	Rattus norvegicus	0-4
12140189-6	2002	While human frataxin has no tendency to bind iron, CyaY forms iron-promoted aggregates with a behaviour similar to that of yeast frataxin.	Iron	62-66	frataxin	Homo sapiens	51-55
8961933-4	1996	IRP1, the well-characterized IRP in cells, is a dual-function protein exhibiting either aconitase activity when cellular iron is abundant or RNA-binding activity when cellular iron is scarce.	Iron	176-180	aconitase 1	Rattus norvegicus	0-4
12137512-2	2002	The intermediate [2Fe-2S] IscU-bound cluster is formed by delivery of iron and sulfur to the apo-IscU, with the latter delivered through an IscS-mediated reaction.	Iron	70-74	NFS1 cysteine desulfurase	Homo sapiens	140-144
12137512-5	2002	This iron-bound form of IscU is shown to be viable for subsequent IscS-mediated assembly of holo-IscU.	Iron	5-9	NFS1 cysteine desulfurase	Homo sapiens	66-70
12117429-0	2002	Differences in iron requirements by concanavalin A-treated and anti-CD3-treated murine splenic lymphocytes.	Iron	15-19	CD3 antigen, epsilon polypeptide	Mus musculus	68-71
9222418-3	1996	The derived protein sequences of NifH, NifD and NifK contained conserved cysteine residues for binding iron-sulfur clusters and the iron-molybdenum cofactor.	Iron	103-107	nitrogenase iron protein	Herbaspirillum seropedicae	33-37
9222418-3	1996	The derived protein sequences of NifH, NifD and NifK contained conserved cysteine residues for binding iron-sulfur clusters and the iron-molybdenum cofactor.	Iron	132-136	nitrogenase iron protein	Herbaspirillum seropedicae	33-37
12085354-2	2002	The aim of the present study was to address the regulation of transferrin receptor (TfR), which mediates cellular iron uptake, during I/R.	Iron	114-118	transferrin receptor	Rattus norvegicus	62-82
8937451-1	1996	In mice, depression of hepatic uroporphyrinogen decarboxylase (UROD) leading to porphyrin accumulation (uroporphyria) occurs with chlorinated ligands of the aryl hydrocarbon (AH) receptor especially after iron overload.	Iron	205-209	uroporphyrinogen decarboxylase	Mus musculus	31-61
8937451-1	1996	In mice, depression of hepatic uroporphyrinogen decarboxylase (UROD) leading to porphyrin accumulation (uroporphyria) occurs with chlorinated ligands of the aryl hydrocarbon (AH) receptor especially after iron overload.	Iron	205-209	uroporphyrinogen decarboxylase	Mus musculus	63-67
12085354-2	2002	The aim of the present study was to address the regulation of transferrin receptor (TfR), which mediates cellular iron uptake, during I/R.	Iron	114-118	transferrin receptor	Rattus norvegicus	84-87
12085354-9	2002	The increased expression of TfR at the cell surface resulted in increased uptake of transferrin-bound-iron into surviving liver slices; however, iron was not incorporated into ferritin.	Iron	102-106	transferrin receptor	Rattus norvegicus	28-31
8901794-5	1996	Results from the current study showing the low biological and analytical variability of TfR support the use of this new test for assessing a person"s iron status.	Iron	150-154	transferrin receptor	Homo sapiens	88-91
12085354-9	2002	The increased expression of TfR at the cell surface resulted in increased uptake of transferrin-bound-iron into surviving liver slices; however, iron was not incorporated into ferritin.	Iron	145-149	transferrin receptor	Rattus norvegicus	28-31
12085354-10	2002	In conclusion, HIF-1 mediated activation of TfR gene transcription and IRP-mediated increase of TfR mRNA stability ensure a steady induction of TfR, and hence higher iron uptake in reperfused rat liver.	Iron	166-170	caspase 3	Rattus norvegicus	71-74
12085354-10	2002	In conclusion, HIF-1 mediated activation of TfR gene transcription and IRP-mediated increase of TfR mRNA stability ensure a steady induction of TfR, and hence higher iron uptake in reperfused rat liver.	Iron	166-170	transferrin receptor	Rattus norvegicus	96-99
15299585-1	1996	Lactoferrin is an iron-binding glycoprotein with a molecular weight of 80 kDa.	Iron	18-22	inhibitor of carbonic anhydrase	Equus caballus	0-11
12085354-10	2002	In conclusion, HIF-1 mediated activation of TfR gene transcription and IRP-mediated increase of TfR mRNA stability ensure a steady induction of TfR, and hence higher iron uptake in reperfused rat liver.	Iron	166-170	transferrin receptor	Rattus norvegicus	96-99
12085354-11	2002	TfR-mediated entry of the metal into liver cells may represent a source of catalytically active iron, which may play a role in reperfusion damage.	Iron	96-100	transferrin receptor	Rattus norvegicus	0-3
8920996-2	1996	Here we demonstrate that in human erythroleukaemic cells (K562) alpha 1-AT enhances the binding affinity of iron-regulatory protein (IRP), the central regulator of cellular iron metabolism, to iron-responsive elements.	Iron	108-112	Wnt family member 2	Homo sapiens	133-136
8920996-2	1996	Here we demonstrate that in human erythroleukaemic cells (K562) alpha 1-AT enhances the binding affinity of iron-regulatory protein (IRP), the central regulator of cellular iron metabolism, to iron-responsive elements.	Iron	173-177	Wnt family member 2	Homo sapiens	108-131
12111837-10	2002	These developmental changes in IRP and transporter expression suggest potentially different time periods of brain structure vulnerability to iron deficiency or iron overload.	Iron	141-145	caspase 3	Rattus norvegicus	31-34
8920996-2	1996	Here we demonstrate that in human erythroleukaemic cells (K562) alpha 1-AT enhances the binding affinity of iron-regulatory protein (IRP), the central regulator of cellular iron metabolism, to iron-responsive elements.	Iron	173-177	Wnt family member 2	Homo sapiens	133-136
12034867-5	2002	The TAT system proved essential for the export of phospholipases, proteins involved in pyoverdine-mediated iron-uptake, anaerobic respiration, osmotic stress defense, motility, and biofilm formation.	Iron	107-111	tyrosine aminotransferase	Homo sapiens	4-7
8958006-4	1996	The highest percentage levels of intrinsic Fe were always found in the HMW fractions, independent of the type and the level of proteins studied, while in the case of Zn, both HMW and LMW fractions gave similar values.	Iron	43-45	cilia and flagella associated protein 97	Homo sapiens	71-74
8958006-8	1996	We postulate that the effect of a protein on the absorption of extrinsic Fe could be accounted for by free amino acids and/or small peptides released during the digestion process and also by the undigested or partially-digested HMW fractions of hydrolysed proteins which could play a fundamental role in the availability of this essential element.	Iron	73-75	cilia and flagella associated protein 97	Homo sapiens	228-231
8885838-2	1996	It is the binding site of the iron responsive protein (IRP), and the interaction is part of the regulation of cellular iron metabolism.	Iron	30-34	Wnt family member 2	Homo sapiens	55-58
8831290-1	1996	Iron uptake and storage in mammalian cells is at least partly regulated at a post-transcriptional level by the iron regulatory proteins (IRP-1 and IRP-2).	Iron	0-4	aconitase 1	Homo sapiens	137-142
8831290-1	1996	Iron uptake and storage in mammalian cells is at least partly regulated at a post-transcriptional level by the iron regulatory proteins (IRP-1 and IRP-2).	Iron	111-115	aconitase 1	Homo sapiens	137-142
12044177-5	2002	SIN-1 was used also in lysates of J774A.1 mouse macrophages grown under control conditions, or subjected to iron loading or starvation by treatment with hemin or desferrioxamine, respectively.	Iron	108-112	mitogen-activated protein kinase associated protein 1	Mus musculus	0-5
8831290-3	1996	The IRP:IRE interaction underlies the regulation of translation and stability of several mRNAs central to iron metabolism.	Iron	106-110	Wnt family member 2	Homo sapiens	4-7
8831290-6	1996	They are coordinately regulated by cellular iron, but whereas IRP-1 is inactivated by high iron levels, IRP-2 is rapidly degraded.	Iron	44-48	aconitase 1	Homo sapiens	62-67
8831290-6	1996	They are coordinately regulated by cellular iron, but whereas IRP-1 is inactivated by high iron levels, IRP-2 is rapidly degraded.	Iron	91-95	aconitase 1	Homo sapiens	62-67
8831290-9	1996	These findings hint that IRP-1 and IRP-2 may bind preferentially to certain mRNAs in vivo, possibly extending their known functions beyond the regulation of intracellular iron homeostasis.	Iron	171-175	aconitase 1	Homo sapiens	25-30
12023366-6	2002	We found that incubation with low concentrations of crocidolite asbestos (0.5-1.25 microg/cm(2)) resulted in an increase in nuclear Ref-1 protein after 5 min, with a persistent elevation in protein up to 24 h. Additionally, an increase in nuclear Ref-1 could be induced by treating the cells with an oxidant-generating stimulus (iron loading plus PMA) and inhibited by diphenyleneiodonium chloride, an inhibitor of NADPH oxidase.	Iron	329-333	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	132-137
8836047-1	1996	Cellular iron homeostasis is regulated by the cytoplasmic iron regulatory protein (IRP), which binds to iron-responsive elements (IRE) of mRNAs, modulating iron uptake and sequestration, respectively.	Iron	9-13	Wnt family member 2	Homo sapiens	83-86
8836047-1	1996	Cellular iron homeostasis is regulated by the cytoplasmic iron regulatory protein (IRP), which binds to iron-responsive elements (IRE) of mRNAs, modulating iron uptake and sequestration, respectively.	Iron	58-62	Wnt family member 2	Homo sapiens	83-86
8836047-1	1996	Cellular iron homeostasis is regulated by the cytoplasmic iron regulatory protein (IRP), which binds to iron-responsive elements (IRE) of mRNAs, modulating iron uptake and sequestration, respectively.	Iron	58-62	Wnt family member 2	Homo sapiens	83-86
8836047-2	1996	When iron is scarce, IRP binds to IRE and coordinately increases the synthesis of transferrin receptor and decreases that of ferritin, thus providing the cell with readily available free iron.	Iron	5-9	Wnt family member 2	Homo sapiens	21-24
8836047-2	1996	When iron is scarce, IRP binds to IRE and coordinately increases the synthesis of transferrin receptor and decreases that of ferritin, thus providing the cell with readily available free iron.	Iron	187-191	Wnt family member 2	Homo sapiens	21-24
12067343-6	2002	Regulation of CaCCC2 and the phenotype of the homozygous CaCCC2 deletion indicate that it is required for high-affinity iron import, making it the bona fide CCC2 homologue of C. albicans.	Iron	120-124	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	16-20
8836047-3	1996	When iron is in excess, IRP does not bind and iron sequestration prevails over iron uptake.	Iron	5-9	Wnt family member 2	Homo sapiens	24-27
8836047-14	1996	and H2O2 can directly but reversibly down-regulate the RNA-binding activity of IRP, causing transient decrease of free iron that otherwise would convert them into more potent oxidants such as hydroxyl radicals or equally aggressive iron-peroxo complexes.	Iron	119-123	Wnt family member 2	Homo sapiens	79-82
8836047-14	1996	and H2O2 can directly but reversibly down-regulate the RNA-binding activity of IRP, causing transient decrease of free iron that otherwise would convert them into more potent oxidants such as hydroxyl radicals or equally aggressive iron-peroxo complexes.	Iron	232-236	Wnt family member 2	Homo sapiens	79-82
8804407-6	1996	The root system of the recessive mutant fer is unable to induce any of the characteristic responses to iron deficiency and iron uptake is thus completely blocked.	Iron	123-127	bHLH transcriptional regulator	Solanum lycopersicum	40-43
8804407-7	1996	We present a characterization of the double mutant, showing that the fer gene is epistatic over the chln gene and thus very likely to be one of the major genetic elements controlling iron physiology in tomato.	Iron	183-187	bHLH transcriptional regulator	Solanum lycopersicum	69-72
8804407-11	1996	The isolation of the fer gene will provide new insights into the molecular mechanisms of iron uptake control in plants.	Iron	89-93	bHLH transcriptional regulator	Solanum lycopersicum	21-24
12023025-0	2002	Single point mutation in the Rieske iron-sulfur subunit of cytochrome b6/f leads to an altered pH dependence of plastoquinol oxidation in Arabidopsis.	Iron	36-40	cytochrome b6	Arabidopsis thaliana	59-74
11986241-1	2002	Friedreich ataxia (FA) is caused by decreased frataxin expression that results in mitochondrial iron (Fe) overload.	Iron	96-100	frataxin	Homo sapiens	46-54
8706892-4	1996	Here we show that purified MoaA contains approximately 4 microM Fe and approximately 3 microM acid-labile S/microM protein.	Iron	64-66	moaA	Paenarthrobacter nicotinovorans	27-31
11986241-1	2002	Friedreich ataxia (FA) is caused by decreased frataxin expression that results in mitochondrial iron (Fe) overload.	Iron	102-104	frataxin	Homo sapiens	46-54
11986241-3	2002	In this investigation we examined the function of frataxin in Fe metabolism by implementing a well-characterized model of erythroid differentiation, namely, Friend cells induced using dimethyl sulfoxide (DMSO).	Iron	62-64	frataxin	Homo sapiens	50-58
12019217-1	2002	The mitochondrial protein frataxin helps maintain appropriate iron levels in the mitochondria of yeast and humans.	Iron	62-66	frataxin	Homo sapiens	26-34
27327385-4	1996	METHODS: CaF2 :Dy or CaF2 was sensitized to UV by heating for 1-3 h to 750-950(o) C on different supports (porcelain, steel, preheated steel, silicon, chromium, manganese, iron, cobalt, nickel, copper, Fe2 O3 , Fe3 O4 ).	Iron	172-176	CCR4-NOT transcription complex subunit 8	Homo sapiens	9-13
27327385-4	1996	METHODS: CaF2 :Dy or CaF2 was sensitized to UV by heating for 1-3 h to 750-950(o) C on different supports (porcelain, steel, preheated steel, silicon, chromium, manganese, iron, cobalt, nickel, copper, Fe2 O3 , Fe3 O4 ).	Iron	172-176	CCR4-NOT transcription complex subunit 8	Homo sapiens	21-25
11970939-1	2002	BACKGROUND AND AIMS: Increased generation of reactive oxygen species and mitochondrial dysfunction may underlie the pathophysiology of Friedreich"s ataxia, the most common inherited ataxia, due to GAA expansion in a gene coding for a mitochondrial protein (frataxin), implicated in the regulation of iron metabolism.	Iron	300-304	alpha glucosidase	Homo sapiens	197-200
8695634-18	1996	In this form it is known as the iron regulatory protein (IRP) and the stem-loop RNA structure to which it binds is the iron regulatory element (IRE).	Iron	32-36	Wnt family member 2	Homo sapiens	57-60
12020255-2	2002	Friedreich ataxia results from a deficiency of functional frataxin, a protein that appears to be involved in mitochondrial iron homeostasis.	Iron	123-127	frataxin	Homo sapiens	58-66
12367579-7	2002	This forced dichotomy between the absence of HFE in the crypt and expression in the villi provides experimental support that HFE functions as a "gatekeeper," regulating the cross-talk between the crypt and villi enterocytes and thereby modulating the avidity of mature enterocytes for dietary iron.	Iron	293-297	homeostatic iron regulator	Rattus norvegicus	125-128
11891134-5	2002	Both deduced amino acid sequences show substantial similarity to human IRP1 and Drosophila IRP1A and IRP1B, and all of the residues thought to be involved in aconitase activity and iron-sulfur cluster formation are conserved.	Iron	181-185	aconitase 1	Homo sapiens	71-75
11983074-3	2002	On the other hand, its paralog, IscS, exhibits higher activity for L-cysteine, which acts as a sulfur donor during the biosynthesis of the iron-sulfur cluster and 4-thiouridine.	Iron	139-143	NFS1 cysteine desulfurase	Homo sapiens	32-36
11888523-8	2002	We conclude that blood donation, and thereby a lowered body iron concentration, is an effective way to increase the oxidative potential of LDL, as well as the HDL and apoA concentrations.	Iron	60-64	lipoprotein(a)	Homo sapiens	167-171
11943417-1	2002	BACKGROUND/AIMS: HFE-related haemochromatosis is a common disorder of iron metabolism.	Iron	70-74	homeostatic iron regulator	Homo sapiens	17-20
12014663-5	2002	CYP2E1 inhibitors markedly reduced H2O2 generation with the preservation of CYP2E1 content, markedly decreased in iron and hydroxyl radical formation associated with significant attenuation in cytotoxicity.	Iron	114-118	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	0-6
12014663-6	2002	CONCLUSION: CYP2E1 plays an important role in CP-induced cytotoxicity by severing as a site for the generation of ROS and a significant source of catalytic iron.	Iron	156-160	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	12-18
11887210-10	2002	The presence of C282Y homozygosity in roughly half of the Brazilian patients with HH, together with the findings of HLA-A homozygosity in C282Y-negative subjects, suggest that other mutations in the HFE gene or in other genes involved in iron homeostasis might also be linked to HH in Brazil.	Iron	238-242	homeostatic iron regulator	Homo sapiens	199-202
12168723-2	2002	Iron induced generation of reactive oxygen species (ROS) in vitro reduces both the Na+K+-ATPase activity and Na+-Ca2+ exchanger of synaptosomal membranes, concomitantly with alteration of physical state of membranes.	Iron	0-4	dynein axonemal heavy chain 8	Homo sapiens	89-95
11886477-3	2002	In particular, the identification of the haemochromatosis gene (HFE) and more recently the transferrin receptor 2 gene (TfR2) together with the specific mutations in these genes which result in hepatic iron overload, has enhanced our understanding of the pathophysiology of haemochromatosis.	Iron	202-206	homeostatic iron regulator	Homo sapiens	64-67
11869803-1	2002	In a previous study, we found that human ceruloplasmin (hCP) promotes iron uptake rather than release in BT325 cells, a human glioma cell line.	Iron	70-74	coproporphyrinogen oxidase	Homo sapiens	56-59
11869803-2	2002	In this study, we investigated the effect of ferroxidase activity of hCP and different species of ceruloplasmins on CP-mediated iron uptake by the cells.	Iron	128-132	coproporphyrinogen oxidase	Homo sapiens	69-72
11869803-2	2002	In this study, we investigated the effect of ferroxidase activity of hCP and different species of ceruloplasmins on CP-mediated iron uptake by the cells.	Iron	128-132	coproporphyrinogen oxidase	Homo sapiens	70-72
11869803-4	2002	The untreated hCP induced a significant increase in iron uptake by BT325 cells, while ferroxidase-defective hCPs with (heat-inactivated hCP) or without cooper ions (apohCP) had no such role.	Iron	52-56	coproporphyrinogen oxidase	Homo sapiens	14-17
11869803-5	2002	The untreated hCP increases significantly internalized iron but not membrane-bound iron, implying that hCP stimulated iron entry into the cell rather than increased extracellular binding of iron to the cell surface.	Iron	55-59	coproporphyrinogen oxidase	Homo sapiens	14-17
11842150-1	2002	Chlamydomonas reinhardtii activates Cpx1, Cyc6, and Crd1, encoding, respectively, coproporphyrinogen oxidase, cytochrome c(6), and a novel di-iron enzyme when transferred to oxygen-deficient growth conditions.	Iron	142-146	uncharacterized protein	Chlamydomonas reinhardtii	42-46
11755321-5	2002	In iron-overloaded mice, GSTA4 staining was more intense in cells that preferentially accumulated iron, and conjugation of 4-hydroxynonenal, a specific substrate of GSTA4, was enhanced in both organs.	Iron	3-7	glutathione S-transferase, alpha 4	Mus musculus	25-30
11755321-5	2002	In iron-overloaded mice, GSTA4 staining was more intense in cells that preferentially accumulated iron, and conjugation of 4-hydroxynonenal, a specific substrate of GSTA4, was enhanced in both organs.	Iron	3-7	glutathione S-transferase, alpha 4	Mus musculus	165-170
11755321-5	2002	In iron-overloaded mice, GSTA4 staining was more intense in cells that preferentially accumulated iron, and conjugation of 4-hydroxynonenal, a specific substrate of GSTA4, was enhanced in both organs.	Iron	98-102	glutathione S-transferase, alpha 4	Mus musculus	25-30
11755321-7	2002	These data demonstrate that GSTA1 and M1 are differentially regulated in liver and kidney while GSTA4 is induced in both organs during iron overload.	Iron	135-139	glutathione S-transferase, alpha 4	Mus musculus	96-101
11755321-8	2002	Moreover, they support the view that iron-induction of GSTA4 is related to an overproduction of free radicals.	Iron	37-41	glutathione S-transferase, alpha 4	Mus musculus	55-60
11782496-0	2002	Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator.	Iron	10-14	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	72-76
11782496-11	2002	Deletion of the TUP1 regulator perturbed the homeostatic control of reductive iron uptake.	Iron	78-82	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	16-20
11782496-13	2002	The opposite regulation of two iron permease genes and the role of TUP1 indicate that the process of iron acquisition by C. albicans may be more complex and potentially more adaptable than by S. cerevisiae.	Iron	101-105	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	67-71
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	126-130	Fit1p	Saccharomyces cerevisiae S288C	0-4
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	126-130	Fit2p	Saccharomyces cerevisiae S288C	6-10
11673473-3	2001	Northern blot analysis confirmed that FIT1, FIT2, and FIT3 mRNA transcript levels were increased 60-230-fold in response to iron deprivation in an Aft1p-dependent manner.	Iron	124-128	Fit1p	Saccharomyces cerevisiae S288C	38-42
11673473-3	2001	Northern blot analysis confirmed that FIT1, FIT2, and FIT3 mRNA transcript levels were increased 60-230-fold in response to iron deprivation in an Aft1p-dependent manner.	Iron	124-128	Fit2p	Saccharomyces cerevisiae S288C	44-48
11673473-9	2001	Fit1p, Fit2p, and Fit3p may function by increasing the amount of iron associated with the cell wall and periplasmic space.	Iron	65-69	Fit1p	Saccharomyces cerevisiae S288C	0-5
11673473-9	2001	Fit1p, Fit2p, and Fit3p may function by increasing the amount of iron associated with the cell wall and periplasmic space.	Iron	65-69	Fit2p	Saccharomyces cerevisiae S288C	7-12
11838713-6	2001	Digestion with neuraminidase reduced the colloidal iron staining on the luminal surface coat of the HEV.	Iron	51-55	neuraminidase 1	Homo sapiens	15-28
8795021-6	1996	Finally, the extrapolated intercept at LF = 0 for both 1/T1 and 1/T2 indicates a contribution from a small number of iron ions bound to the protein shell.	Iron	117-121	interleukin 1 receptor like 1	Homo sapiens	57-65
11729128-5	2001	This association directly links HFE protein to the TfR-mediated regulation of iron homeostasis.	Iron	78-82	homeostatic iron regulator	Homo sapiens	32-35
8856799-11	1996	In animals exposed to hyperoxia, treatment with iron-free TF decreased malondialdehyde content of BAL.	Iron	48-52	serotransferrin	Oryctolagus cuniculus	58-60
8856799-12	1996	We propose that low iron saturation of TF decreases oxidant stress and favors the recovery from respiratory failure.	Iron	20-24	serotransferrin	Oryctolagus cuniculus	39-41
11729128-5	2001	This association directly links HFE protein to the TfR-mediated regulation of iron homeostasis.	Iron	78-82	transferrin receptor	Homo sapiens	51-54
11728475-0	2001	Mutational analysis of the iron binding site of Saccharomyces cerevisiae ferroxidase Fet3.	Iron	27-31	ferroxidase FET3	Saccharomyces cerevisiae S288C	85-89
12226335-7	1996	We detected ferric-chelate reductase activity associated with the PBM and suggest that reduction of Fe(III) to ferrous [Fe(II)] plays a role in the movement of iron into soybean symbiosomes.	Iron	160-164	chalcone reductase CHR1	Glycine max	27-36
11728475-2	2001	The role of residues predicted to be involved in the binding of iron by the yeast ferroxidase Fet3 has been studied by site-directed mutagenesis.	Iron	64-68	ferroxidase FET3	Saccharomyces cerevisiae S288C	82-98
8682202-0	1996	Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1.	Iron	0-4	aconitase 1	Homo sapiens	71-96
11728475-3	2001	The effect of Fet3 mutations E185A, E185Q, Y354F, D409V and H489D has been investigated in vivo by kinetic analyses of high affinity iron uptake.	Iron	133-137	ferroxidase FET3	Saccharomyces cerevisiae S288C	14-18
8682202-1	1996	In the eighties, iron regulatory protein-1 (IRP-1) was identified as a cytoplasmic mRNA-binding protein that regulates vertebrate cell iron metabolism.	Iron	17-21	aconitase 1	Homo sapiens	44-49
11562378-2	2001	Siderophore-iron uptake can occur through the reduction of the complex and the subsequent uptake of iron by the high affinity iron transporter Fet3p/Ftr1p.	Iron	100-104	ferroxidase FET3	Saccharomyces cerevisiae S288C	143-148
8675172-1	1996	The hepatic uptake of transferrin-bound iron by a nontransferrin receptor (NTR)-mediated process was investigated using the human hepatoma cell line HuH7.	Iron	40-44	neurotensin receptor 1	Homo sapiens	50-73
8675172-1	1996	The hepatic uptake of transferrin-bound iron by a nontransferrin receptor (NTR)-mediated process was investigated using the human hepatoma cell line HuH7.	Iron	40-44	neurotensin receptor 1	Homo sapiens	75-78
8675172-8	1996	Iron uptake mediated by NTR process was saturable and displaced by 100-fold excess unlabeled transferrin and reduced by weak bases and metabolic inhibitors.	Iron	0-4	neurotensin receptor 1	Homo sapiens	24-27
8675172-9	1996	Therefore, the NTR-mediated process entailed transferrin adsorption to membrane-bound proteins, internalization, and release of iron from transferrin by a pH-dependent step followed by the intracellular transport of iron into ferritin and heme by a saturable carrier-mediated mechanism.	Iron	128-132	neurotensin receptor 1	Homo sapiens	15-18
8675172-9	1996	Therefore, the NTR-mediated process entailed transferrin adsorption to membrane-bound proteins, internalization, and release of iron from transferrin by a pH-dependent step followed by the intracellular transport of iron into ferritin and heme by a saturable carrier-mediated mechanism.	Iron	216-220	neurotensin receptor 1	Homo sapiens	15-18
11692063-16	2001	CONCLUSIONS: Liver iron accumulation is mild in chronic hepatitis C patients without HFE mutations and is mainly reflected by serum ferritin levels.	Iron	19-23	homeostatic iron regulator	Homo sapiens	85-88
8643505-5	1996	In a cell-free translation system, recombinant IRP-1 imposes highly specific translational repression on a reporter mRNA bearing the SDH IRE, and the translation of SDH-Ip mRNA is iron regulated in D. melanogaster Schneider cells.	Iron	180-184	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	165-171
8634912-7	1996	When cells were treated with the iron chelator desferrioxamine to stimulate IRP binding to the wild-type IRE, frameshift activity was specifically and strongly augmented by protein binding Our data establish that frameshifting can be regulated in a reversible fashion by mRNA-binding proteins.	Iron	33-37	Wnt family member 2	Homo sapiens	76-79
11694604-6	2001	Although IRP binding activity is predominantly located in the cytosol (90%), there was increased IRP/IRE binding activity in both cytosolic and membrane fractions when the cells were treated with deferoxamine, and decreased binding activity after treatment with iron.	Iron	262-266	caspase 3	Rattus norvegicus	9-12
8739601-1	1996	This paper describes the ability of human and bovine lactoferrins (HLf; BLf), iron-binding proteins belonging to the non-immune defense system, to interfere with herpes simplex virus type 1 (HSV-1) infection.	Iron	78-82	HLF transcription factor, PAR bZIP family member	Bos taurus	67-70
11694604-7	2001	In the rat study, brain cortex, hippocampus and striatum homogenates had more IRP binding activity in iron-deficient rats and less in iron-supplemented rats in a region- and time-specific manner.	Iron	102-106	caspase 3	Rattus norvegicus	78-81
11581431-0	2001	Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis.	Iron	159-163	homeostatic iron regulator	Homo sapiens	74-77
8634457-8	1996	Gel retardation assays performed on cytoplasmic extracts of transfected cells using an iron-responsive element (IRE) as a probe revealed that in overexpressing cells, the iron-regulatory protein (IRP) had a conformation with a high RNA-binding affinity, thus leading to translational repression of the endogenous L-ferritin synthesis.	Iron	87-91	wingless-type MMTV integration site family, member 2	Mus musculus	171-194
8634457-8	1996	Gel retardation assays performed on cytoplasmic extracts of transfected cells using an iron-responsive element (IRE) as a probe revealed that in overexpressing cells, the iron-regulatory protein (IRP) had a conformation with a high RNA-binding affinity, thus leading to translational repression of the endogenous L-ferritin synthesis.	Iron	87-91	wingless-type MMTV integration site family, member 2	Mus musculus	196-199
8608889-2	1996	This study aimed to determine the regulation of transferrin receptor and ferritin messenger RNA (mRNA) in the rat gastrointestinal tract in response to dietary iron changes.	Iron	160-164	transferrin receptor	Rattus norvegicus	48-68
11581431-2	2001	There is evidence linking HFE with reduced iron uptake by the transferrin receptor (TfR).	Iron	43-47	homeostatic iron regulator	Homo sapiens	26-29
11581431-2	2001	There is evidence linking HFE with reduced iron uptake by the transferrin receptor (TfR).	Iron	43-47	transferrin receptor	Homo sapiens	62-82
8617762-8	1996	These findings suggest that IRP-1 and IRP-2 may each regulate unique mRNA targets in vivo, possibly extending their function beyond the regulation of intracellular iron homeostasis.	Iron	164-168	aconitase 1	Homo sapiens	28-33
11581431-2	2001	There is evidence linking HFE with reduced iron uptake by the transferrin receptor (TfR).	Iron	43-47	transferrin receptor	Homo sapiens	84-87
8821818-2	1996	In this model, myoglobin released from the injured muscle is generally accepted as a source of iron.	Iron	95-99	myoglobin	Rattus norvegicus	15-24
17582936-5	2001	The possibility to identify HFE heterozygotes by means of a simple genetic test have prompted studies on the association between HFE mutations and iron overload syndromes different from HH.	Iron	147-151	homeostatic iron regulator	Homo sapiens	28-31
8795105-2	1996	The highest TfR numbers are observed in cells cultured in iron-poor culture medium.	Iron	58-62	transferrin receptor	Homo sapiens	12-15
8795105-3	1996	Investigated were the implications of the variation in surface TfR numbers on the uptake of iron by cytotrophoblasts cultured in iron-poor Medium-199.	Iron	92-96	transferrin receptor	Homo sapiens	63-66
8795105-5	1996	Homeostasis of iron uptake could be explained by adaptive changes in the rate constant for TfR endocytosis (kend), exocytosis (kexo) and TfR cycle times.	Iron	15-19	transferrin receptor	Homo sapiens	91-94
8795105-5	1996	Homeostasis of iron uptake could be explained by adaptive changes in the rate constant for TfR endocytosis (kend), exocytosis (kexo) and TfR cycle times.	Iron	15-19	transferrin receptor	Homo sapiens	137-140
8795105-10	1996	It is concluded that differentiating cytotrophoblasts regulate iron uptake by variation of both TfR numbers and the rate of receptor-mediated endocytosis and exocytosis.	Iron	63-67	transferrin receptor	Homo sapiens	96-99
17582936-5	2001	The possibility to identify HFE heterozygotes by means of a simple genetic test have prompted studies on the association between HFE mutations and iron overload syndromes different from HH.	Iron	147-151	homeostatic iron regulator	Homo sapiens	129-132
11722405-1	2001	Transferrin receptor (TfR, CD71) is an integral membrane glycoprotein that mediates cellular uptake of iron.	Iron	103-107	transferrin receptor	Homo sapiens	0-20
8530520-0	1995	Succinate dehydrogenase b mRNA of Drosophila melanogaster has a functional iron-responsive element in its 5"-untranslated region.	Iron	75-79	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	0-25
8530520-2	1995	IRP-IRE interactions mediate the coordinate post-transcriptional regulation of key proteins in iron metabolism, such as ferritin, transferrin receptor, and erythroid 5-aminolevulinic acid synthase.	Iron	95-99	Ferritin 1 heavy chain homologue	Drosophila melanogaster	120-128
8530520-6	1995	Under conditions of iron deprivation, SDHb mRNA of Drosophila SL-2 cells shifts to a non-polysome-bound pool.	Iron	20-24	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	38-42
8530520-10	1995	Furthermore, Drosophila SDHb represents the second example, after porcine mitochondrial aconitase, of an enzyme of the citric acid cycle whose mRNA possesses all necessary features for translational regulation by cellular iron levels.	Iron	222-226	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	24-28
11722405-1	2001	Transferrin receptor (TfR, CD71) is an integral membrane glycoprotein that mediates cellular uptake of iron.	Iron	103-107	transferrin receptor	Homo sapiens	22-25
11722405-1	2001	Transferrin receptor (TfR, CD71) is an integral membrane glycoprotein that mediates cellular uptake of iron.	Iron	103-107	transferrin receptor	Homo sapiens	27-31
11600067-0	2001	Iron and zinc bioavailability in rats fed intrinsically labeled bean and bean-rice infant weaning food products.	Iron	0-4	brain expressed, associated with NEDD4, 1	Rattus norvegicus	73-77
7499355-5	1995	Mutant yeast cells expressing COPT1 exhibit nearly wild type behavior with regard to growth on a nonfermentable carbon source and resistance to copper and iron starvation.	Iron	155-159	copper transporter 1	Arabidopsis thaliana	30-35
11448968-6	2001	Because a fet3 mutant does not show this deficiency, the defect is not solely caused by mis-regulation of iron transport but also involves defective iron use by the cells.	Iron	106-110	ferroxidase FET3	Saccharomyces cerevisiae S288C	10-14
7579417-1	1995	The iron-responsive element-binding protein (IRE-BP) modulates both ferritin mRNA translation and transferrin receptor (TfR) mRNA stability by binding to specific mRNA sequences called iron-responsive elements (IREs).	Iron	4-8	aconitase 1	Homo sapiens	45-51
7579417-1	1995	The iron-responsive element-binding protein (IRE-BP) modulates both ferritin mRNA translation and transferrin receptor (TfR) mRNA stability by binding to specific mRNA sequences called iron-responsive elements (IREs).	Iron	4-8	transferrin receptor	Homo sapiens	98-118
7579417-1	1995	The iron-responsive element-binding protein (IRE-BP) modulates both ferritin mRNA translation and transferrin receptor (TfR) mRNA stability by binding to specific mRNA sequences called iron-responsive elements (IREs).	Iron	4-8	transferrin receptor	Homo sapiens	120-123
7579417-2	1995	The regulation of IRE-BP in situ could possibly occur either through its Fe-S cluster and/or via free cysteine sulphydryl groups such as cysteine 437 (Philpott et al, J Biol Chem 268:17655, 1993; and Hirling et al, EMBO J 13:453, 1994).	Iron	73-75	aconitase 1	Homo sapiens	18-24
11448968-6	2001	Because a fet3 mutant does not show this deficiency, the defect is not solely caused by mis-regulation of iron transport but also involves defective iron use by the cells.	Iron	149-153	ferroxidase FET3	Saccharomyces cerevisiae S288C	10-14
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	54-58	aconitase 1	Homo sapiens	0-4
11558326-8	2001	Finally, the identification of the HFE gene has paved the way for the identification of new iron overload entities.	Iron	92-96	homeostatic iron regulator	Homo sapiens	35-38
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	aconitase 1	Homo sapiens	0-4
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	aconitase 1	Homo sapiens	60-64
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	aconitase 1	Homo sapiens	0-4
7665579-2	1995	IRP1 and IRP2 RNA binding activities are regulated by iron; IRP1 and IRP2 bind IREs with high affinity in iron-depleted cells and with low affinity in iron-repleted cells.	Iron	106-110	aconitase 1	Homo sapiens	60-64
11579943-2	2001	This study was performed to evaluate the clinical significance of two mutations, C282Y and H63D of HFE, in Japanese patients with hepatic iron overload.	Iron	138-142	homeostatic iron regulator	Homo sapiens	99-102
7577640-0	1995	Interleukin-11 enhances gastrointestinal absorption of iron in rats.	Iron	55-59	interleukin 11	Rattus norvegicus	0-14
7577640-1	1995	The effect of parenteral administration of IL-11 on gastrointestinal iron absorption was evaluated.	Iron	69-73	interleukin 11	Rattus norvegicus	43-48
7657289-5	1995	Hepatic endogenous IRE-BP activity was inversely related to hepatic iron concentration (r = .59, P &lt; .0002).	Iron	68-72	aconitase 1	Homo sapiens	19-25
7657289-2	1995	IRE-BP activity was assessed in liver biopsy specimens in 36 patients--16 hemochromatosis homozygotes, 4 hemochromatosis heterozygotes, 6 patients with secondary iron overload, and 10 control patients with normal hepatic iron concentrations.	Iron	162-166	aconitase 1	Homo sapiens	0-6
7657289-2	1995	IRE-BP activity was assessed in liver biopsy specimens in 36 patients--16 hemochromatosis homozygotes, 4 hemochromatosis heterozygotes, 6 patients with secondary iron overload, and 10 control patients with normal hepatic iron concentrations.	Iron	221-225	aconitase 1	Homo sapiens	0-6
7657289-9	1995	This suggests that both endogenous IRE-BP activity and the total amount of the protein are downregulated in the liver by tissue iron.	Iron	128-132	aconitase 1	Homo sapiens	35-41
7657289-10	1995	Intestinal IRE-BP activity that regulates intestinal transferrin receptor expression is normal in hemochromatosis and appropriate for the intracellular iron concentration.	Iron	152-156	aconitase 1	Homo sapiens	11-17
7657289-10	1995	Intestinal IRE-BP activity that regulates intestinal transferrin receptor expression is normal in hemochromatosis and appropriate for the intracellular iron concentration.	Iron	152-156	transferrin receptor	Homo sapiens	53-73
7544791-0	1995	Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron.	Iron	83-87	aconitase 1	Homo sapiens	52-57
7544791-2	1995	Iron regulatory proteins (IRPs)-1 and -2 bind specific mRNA hairpin structures known as iron-responsive elements and thereby post-transcriptionally regulate proteins involved in iron uptake, storage, and utilization.	Iron	88-92	aconitase 1	Homo sapiens	0-40
7544791-2	1995	Iron regulatory proteins (IRPs)-1 and -2 bind specific mRNA hairpin structures known as iron-responsive elements and thereby post-transcriptionally regulate proteins involved in iron uptake, storage, and utilization.	Iron	178-182	aconitase 1	Homo sapiens	0-40
7544791-5	1995	The in vivo iron regulation of IRP-1 and IRP-2 appeared to involve different pathways.	Iron	12-16	aconitase 1	Homo sapiens	31-36
7544791-9	1995	Immunoblot analysis suggests that iron modulation of IRP-1 activity is predominantly a posttranslational process.	Iron	34-38	aconitase 1	Homo sapiens	53-58
8574041-4	1995	The changes in both T1-weighted and T2-weighted ratios were consistent with the hypothesis that 1/T1 and 1/T2 vary linearly with iron concentration, and the corresponding coefficients, determined separately from the interregional and intraregional plots, were generally in agreement.	Iron	129-133	interleukin 1 receptor like 1	Homo sapiens	98-106
7649160-9	1995	This raises the possibility that the differential accumulation of FM1 and FM2 mRNAs in response to iron, abscisic acid and drought could be due to differential transcription of ZmFer1 and ZmFer2.	Iron	99-103	ferritin-2, chloroplastic	Zea mays	188-194
7544459-6	1995	Using this method we mapped the site at which human iron regulatory protein (IRP) is UV cross-linked to iron responsive element RNA to amino acid residues 116-151.	Iron	52-56	Wnt family member 2	Homo sapiens	77-80
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	38-42	Wnt family member 2	Homo sapiens	185-188
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	101-105	Wnt family member 2	Homo sapiens	185-188
7626132-5	1995	Mutations of the putative transferrin iron-responsive element similarly affected binding of purified iron-regulatory protein and liver cytoplasmic proteins, providing evidence that the IRP is one of the liver cytoplasmic proteins that binds the human transferrin iron-regulatory element and suggesting that it may be involved in iron-regulation of transferrin.	Iron	101-105	Wnt family member 2	Homo sapiens	185-188
7541043-3	1995	In this study, we evaluate the impact of expression of C437S, a mutant of IRP1 that binds IREs regardless of cellular iron status, on the regulation of biosynthesis of ferritin and TfR.	Iron	118-122	aconitase 1	Homo sapiens	74-78
7756260-1	1995	The highly conserved amino acid sequence PCDGPGRGGTC in both photosystem I reaction center core proteins PsaA and PsaB has been predicted to contribute the four cysteine ligands for coordination of the 4Fe-4S iron-sulfur cluster FX, and we have proposed a working model for the binding of PsaC to this domain of the reaction center core heterodimer [Rodday et al.	Iron	209-213	photosystem I P700 chlorophyll a apoprotein A1	Chlamydomonas reinhardtii	105-109
7720713-6	1995	These effects may be explained by the failure of iron to repress transcription of FRE1, FRE2 and FET3.	Iron	49-53	ferroxidase FET3	Saccharomyces cerevisiae S288C	97-101
7720713-7	1995	FRE1 and FRE2 encode plasma membrane ferric reductases, obligatory for ferric iron assimilation, and FET3 encodes a copper-dependent membrane-associated oxidase required for ferrous iron uptake.	Iron	182-186	ferroxidase FET3	Saccharomyces cerevisiae S288C	101-105
7890603-0	1995	Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.	Iron	111-115	aconitase 1	Homo sapiens	153-157
7741221-4	1995	In euykarotic cells, iron homeostasis is dependent upon the iron regulatory factor (IRF), a cytoplasmic protein that can bind to specific stem loops, iron responsive elements (IREs) on the messenger ribonucleic acid molecules (mRNAs) of proteins involved in iron storage (ferritin), utilization (erythroid delta-aminolaevulinate synthase, AIS), and uptake (transferrin receptor).	Iron	21-25	transferrin receptor	Homo sapiens	357-377
7741221-4	1995	In euykarotic cells, iron homeostasis is dependent upon the iron regulatory factor (IRF), a cytoplasmic protein that can bind to specific stem loops, iron responsive elements (IREs) on the messenger ribonucleic acid molecules (mRNAs) of proteins involved in iron storage (ferritin), utilization (erythroid delta-aminolaevulinate synthase, AIS), and uptake (transferrin receptor).	Iron	60-64	transferrin receptor	Homo sapiens	357-377
7741221-4	1995	In euykarotic cells, iron homeostasis is dependent upon the iron regulatory factor (IRF), a cytoplasmic protein that can bind to specific stem loops, iron responsive elements (IREs) on the messenger ribonucleic acid molecules (mRNAs) of proteins involved in iron storage (ferritin), utilization (erythroid delta-aminolaevulinate synthase, AIS), and uptake (transferrin receptor).	Iron	60-64	transferrin receptor	Homo sapiens	357-377
7741221-6	1995	When the cells are iron replete, IRF binding to IREs is weak, allowing transferrin receptor mRNA to be degraded.	Iron	19-23	transferrin receptor	Homo sapiens	71-91
7705347-5	1995	Iron accumulation by vpt13 was not reduced at low extracellular iron concentrations, and only slightly reduced at high external iron.	Iron	0-4	SNAP receptor PEP12	Saccharomyces cerevisiae S288C	21-26
7705347-5	1995	Iron accumulation by vpt13 was not reduced at low extracellular iron concentrations, and only slightly reduced at high external iron.	Iron	64-68	SNAP receptor PEP12	Saccharomyces cerevisiae S288C	21-26
7705347-5	1995	Iron accumulation by vpt13 was not reduced at low extracellular iron concentrations, and only slightly reduced at high external iron.	Iron	128-132	SNAP receptor PEP12	Saccharomyces cerevisiae S288C	21-26
7705347-6	1995	Subcellular fractionation of vpt13 after iron loading confirmed the vacuolar localization of the accumulated iron.	Iron	41-45	SNAP receptor PEP12	Saccharomyces cerevisiae S288C	29-34
7705347-6	1995	Subcellular fractionation of vpt13 after iron loading confirmed the vacuolar localization of the accumulated iron.	Iron	109-113	SNAP receptor PEP12	Saccharomyces cerevisiae S288C	29-34
7876092-4	1995	Furthermore, a chimeric molecule (APP-TR) consisting of the cytoplasmic domain of APP and the transmembrane and external domains of TR was rapidly internalized enabling the transport of iron into the cell at approximately 50% the rate of wild-type TR.	Iron	186-190	transferrin receptor	Homo sapiens	38-40
7836366-0	1995	The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase.	Iron	49-53	ferroxidase FET3	Saccharomyces cerevisiae S288C	4-8
7836366-1	1995	The yeast FET3 gene is required for high affinity iron transport (Askwith, C., Eide, D., Ho, A. V., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., and Kaplan, J.	Iron	50-54	ferroxidase FET3	Saccharomyces cerevisiae S288C	10-14
7836366-5	1995	Cells that contain a functional FET3 gene product exhibited an iron-dependent non-mitochondrial increase in oxygen consumption.	Iron	63-67	ferroxidase FET3	Saccharomyces cerevisiae S288C	32-36
7836366-8	1995	Treatment of spheroplasts with trypsin or affinity-purified antibodies directed against the putative external ferroxidase domain of Fet3 had no effect on basal O2 consumption but inhibited the iron-dependent increase in O2 consumption.	Iron	193-197	ferroxidase FET3	Saccharomyces cerevisiae S288C	132-136
7836366-10	1995	These studies indicate that Fet3 is a plasma membrane ferroxidase required for high affinity iron uptake, in which the ferroxidase-containing domain is localized on the external cell surface.	Iron	93-97	ferroxidase FET3	Saccharomyces cerevisiae S288C	28-32
7762965-12	1995	Iron regulates these proteins post-transcriptionally via iron responsive elements (IRE), which are highly conserved stem-loop structures found in messenger ribonucleic acid (mRNA), and an IRE binding protein (IRE-BP), which responds to increased intracellular iron concentrations by binding the IRE, and repressing mRNA translation or stabilizing the mRNA, depending on whether the IRE is located in the upstream or downstream untranslated regions of the mRNA.	Iron	0-4	aconitase 1	Homo sapiens	188-207
7762965-12	1995	Iron regulates these proteins post-transcriptionally via iron responsive elements (IRE), which are highly conserved stem-loop structures found in messenger ribonucleic acid (mRNA), and an IRE binding protein (IRE-BP), which responds to increased intracellular iron concentrations by binding the IRE, and repressing mRNA translation or stabilizing the mRNA, depending on whether the IRE is located in the upstream or downstream untranslated regions of the mRNA.	Iron	0-4	aconitase 1	Homo sapiens	209-215
7762965-12	1995	Iron regulates these proteins post-transcriptionally via iron responsive elements (IRE), which are highly conserved stem-loop structures found in messenger ribonucleic acid (mRNA), and an IRE binding protein (IRE-BP), which responds to increased intracellular iron concentrations by binding the IRE, and repressing mRNA translation or stabilizing the mRNA, depending on whether the IRE is located in the upstream or downstream untranslated regions of the mRNA.	Iron	260-264	aconitase 1	Homo sapiens	188-207
7762965-12	1995	Iron regulates these proteins post-transcriptionally via iron responsive elements (IRE), which are highly conserved stem-loop structures found in messenger ribonucleic acid (mRNA), and an IRE binding protein (IRE-BP), which responds to increased intracellular iron concentrations by binding the IRE, and repressing mRNA translation or stabilizing the mRNA, depending on whether the IRE is located in the upstream or downstream untranslated regions of the mRNA.	Iron	260-264	aconitase 1	Homo sapiens	209-215
7983023-5	1994	Binding of the IRE-BP to IREs is reversibly regulated by the iron status of the cell.	Iron	61-65	aconitase 1	Homo sapiens	15-21
7994765-1	1994	Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron.	Iron	23-27	transferrin receptor	Mus musculus	78-82
7994765-1	1994	Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron.	Iron	151-155	transferrin receptor	Mus musculus	56-76
7994765-1	1994	Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron.	Iron	151-155	transferrin receptor	Mus musculus	78-82
7982480-6	1994	High affinity copper uptake mediated by the copper transport protein encoded by CTR1 is required to provide the FET3 protein with copper, and thus copper uptake is indirectly required for ferrous iron uptake.	Iron	188-200	ferroxidase FET3	Saccharomyces cerevisiae S288C	112-116
7949105-5	1994	Preincubation of cells with desferrioxamine (DF), a cell-permeable iron chelator, abolished the increments of PKC-beta mRNA observed in response to FeTF or FAC.	Iron	67-71	protein kinase C beta	Homo sapiens	110-118
7949105-7	1994	To locate iron-responsive DNA regulatory elements of the PKC-beta gene, we prepared genetic constructs containing various portions of the human PKC-beta 5"-flanking DNA linked to the firefly luciferase gene.	Iron	10-14	protein kinase C beta	Homo sapiens	57-65
7949105-12	1994	These data provide direct confirmation that iron is involved in regulation of PKC-beta but not PKC-alpha gene expression in many cell lines.	Iron	44-48	protein kinase C beta	Homo sapiens	78-86
7949105-13	1994	The form in which iron is presented to these cell lines appears to affect its availability for this function, and cells vary in their capabilities to use nontransferrin iron to support PKC-beta gene expression.	Iron	18-22	protein kinase C beta	Homo sapiens	185-193
7949105-13	1994	The form in which iron is presented to these cell lines appears to affect its availability for this function, and cells vary in their capabilities to use nontransferrin iron to support PKC-beta gene expression.	Iron	169-173	protein kinase C beta	Homo sapiens	185-193
7984424-3	1994	The regulatory proteins (Rev, Rex or iron response element binding protein IRE-BP) antagonize the effects of the downregulatory elements by interacting directly with specific mRNA sites (Rev responsive element, RRE, Rex responsive element, RXRE, or iron responsive elements, IREs) resulting in stabilization and efficient expression of the corresponding mRNAs.	Iron	37-41	aconitase 1	Homo sapiens	75-81
7984424-3	1994	The regulatory proteins (Rev, Rex or iron response element binding protein IRE-BP) antagonize the effects of the downregulatory elements by interacting directly with specific mRNA sites (Rev responsive element, RRE, Rex responsive element, RXRE, or iron responsive elements, IREs) resulting in stabilization and efficient expression of the corresponding mRNAs.	Iron	37-41	Rev	Human immunodeficiency virus 1	187-190
7984424-3	1994	The regulatory proteins (Rev, Rex or iron response element binding protein IRE-BP) antagonize the effects of the downregulatory elements by interacting directly with specific mRNA sites (Rev responsive element, RRE, Rex responsive element, RXRE, or iron responsive elements, IREs) resulting in stabilization and efficient expression of the corresponding mRNAs.	Iron	249-253	Rev	Human immunodeficiency virus 1	25-28
7984424-3	1994	The regulatory proteins (Rev, Rex or iron response element binding protein IRE-BP) antagonize the effects of the downregulatory elements by interacting directly with specific mRNA sites (Rev responsive element, RRE, Rex responsive element, RXRE, or iron responsive elements, IREs) resulting in stabilization and efficient expression of the corresponding mRNAs.	Iron	249-253	aconitase 1	Homo sapiens	75-81
7984424-3	1994	The regulatory proteins (Rev, Rex or iron response element binding protein IRE-BP) antagonize the effects of the downregulatory elements by interacting directly with specific mRNA sites (Rev responsive element, RRE, Rex responsive element, RXRE, or iron responsive elements, IREs) resulting in stabilization and efficient expression of the corresponding mRNAs.	Iron	249-253	Rev	Human immunodeficiency virus 1	187-190
11390404-3	2001	We demonstrated that endocytosis-defective yeast (Delta end4) can store iron in the vacuole, indicating a transfer of iron from the cytosol to the vacuole.	Iron	72-76	Sla2p	Saccharomyces cerevisiae S288C	56-60
7957580-1	1994	Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake.	Iron	28-32	transferrin receptor	Homo sapiens	61-81
7957580-1	1994	Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake.	Iron	28-32	transferrin receptor	Homo sapiens	83-87
7957580-1	1994	Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake.	Iron	112-116	transferrin receptor	Homo sapiens	61-81
7957580-1	1994	Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake.	Iron	112-116	transferrin receptor	Homo sapiens	83-87
7957580-3	1994	The importance of CD71-mediated iron uptake for proliferation and maturation of thymocytes was studied using fetal thymus organ cultures at day 14 of gestation and treating them for 7 days with a CD71 monoclonal antibody (mAb).	Iron	32-36	transferrin receptor	Homo sapiens	18-22
7957580-11	1994	Thus, our observations indicate that CD71 treatment, causing decreased intracellular iron levels, severely inhibits the major proliferation phase from the CD44-25+ CD4-8-3- to the CD4+8+3- cells, and completely abrogates the final maturation of CD4+8+3- cells into alpha beta TcR-expressing cells.	Iron	85-89	transferrin receptor	Homo sapiens	37-41
11390404-3	2001	We demonstrated that endocytosis-defective yeast (Delta end4) can store iron in the vacuole, indicating a transfer of iron from the cytosol to the vacuole.	Iron	118-122	Sla2p	Saccharomyces cerevisiae S288C	56-60
11529872-4	2001	The influence of HFE genotype on iron status was investigated in 10 556 blood donors.	Iron	33-37	homeostatic iron regulator	Homo sapiens	17-20
7812111-0	1994	Potentiation of iron accumulation in cardiac myocytes during the treatment of iron overload in gerbils with the hydroxypyridinone iron chelator CP94.	Iron	16-20	beaded filament structural protein 1	Homo sapiens	144-148
7812111-0	1994	Potentiation of iron accumulation in cardiac myocytes during the treatment of iron overload in gerbils with the hydroxypyridinone iron chelator CP94.	Iron	78-82	beaded filament structural protein 1	Homo sapiens	144-148
7812111-0	1994	Potentiation of iron accumulation in cardiac myocytes during the treatment of iron overload in gerbils with the hydroxypyridinone iron chelator CP94.	Iron	78-82	beaded filament structural protein 1	Homo sapiens	144-148
7812111-2	1994	The iron chelating hydroxypyridinone, CP94, has been administered prophylactically to iron overloaded gerbils in a dosing regime which favors the formation of bidentate chelated iron, to examine the possibility of additional toxicity being caused to the liver and heart by the bidentate chelated iron complex.	Iron	4-8	beaded filament structural protein 1	Homo sapiens	38-42
7812111-3	1994	Hepatic iron accumulation was inhibited by CP94 administration for up to 6 weeks, but not after 20 weeks.	Iron	8-12	beaded filament structural protein 1	Homo sapiens	43-47
11461780-1	2001	Crocidolite fibers stimulated nitric oxide synthase (NOS) activity and expression in glial and alveolar murine macrophages: this effect was inhibited by iron supplementation and enhanced by iron chelation.	Iron	153-157	nitric oxide synthase 1, neuronal	Mus musculus	30-51
7881182-5	1994	The purified CMP-Neu5Ac hydroxylase is activated by FeSO4 and inhibited by iron-binding reagents such as o-phenanthroline, KCN, Tiron and ferrozine.	Iron	75-79	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Sus scrofa	13-35
11551743-2	2001	When cells in the systemic circulation are depleted of iron, they increase synthesis of the transferrin receptor and decrease synthesis of the iron sequestration protein, ferritin.	Iron	55-59	transferrin receptor	Homo sapiens	92-112
7523370-4	1994	The 4Fe-4S cluster is important for iron-dependent regulation: BP1 containing iron has low affinity for the IRE and contains aconitase activity, whereas BP1 lacking iron has high affinity for the IRE, but lacks aconitase activity.	Iron	36-40	Blood pressure QTL 1	Rattus norvegicus	153-156
7523370-4	1994	The 4Fe-4S cluster is important for iron-dependent regulation: BP1 containing iron has low affinity for the IRE and contains aconitase activity, whereas BP1 lacking iron has high affinity for the IRE, but lacks aconitase activity.	Iron	78-82	Blood pressure QTL 1	Rattus norvegicus	63-66
7523370-4	1994	The 4Fe-4S cluster is important for iron-dependent regulation: BP1 containing iron has low affinity for the IRE and contains aconitase activity, whereas BP1 lacking iron has high affinity for the IRE, but lacks aconitase activity.	Iron	78-82	Blood pressure QTL 1	Rattus norvegicus	63-66
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	85-89	Blood pressure QTL 1	Rattus norvegicus	0-3
11551744-6	2001	This iron-induced oxidative stress is often accentuated by ascorbate and oxidized glutathione, although it is suppressed by the following antioxidants: S-nitrosoglutathione or nitric oxide, MnSOD mimics, manganese, U-78517F, Trolox, and deferoxamine.	Iron	5-9	superoxide dismutase 2	Homo sapiens	190-195
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	85-89	Blood pressure QTL 2	Rattus norvegicus	8-11
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	85-89	Blood pressure QTL 1	Rattus norvegicus	107-110
11313346-2	2001	The translation of many iron proteins is controlled by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem loop structures, known as iron-responsive elements (IREs), found in the untranslated regions of their mRNAs.	Iron	24-28	aconitase 1	Homo sapiens	96-127
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	85-89	Blood pressure QTL 2	Rattus norvegicus	115-118
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	147-151	Blood pressure QTL 1	Rattus norvegicus	0-3
11313346-2	2001	The translation of many iron proteins is controlled by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem loop structures, known as iron-responsive elements (IREs), found in the untranslated regions of their mRNAs.	Iron	24-28	aconitase 1	Homo sapiens	129-133
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	147-151	Blood pressure QTL 2	Rattus norvegicus	8-11
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	147-151	Blood pressure QTL 1	Rattus norvegicus	107-110
7523370-6	1994	BP1 and BP2 RNA binding activities are decreased in extracts from cells treated with iron, indicating that BP1 and BP2 are negatively regulated by iron.	Iron	147-151	Blood pressure QTL 2	Rattus norvegicus	115-118
7523370-8	1994	Unlike BP1 levels, which do not change when RNA binding activity decreases in response to iron, BP2 decreases to undetectable levels in extracts from cells treated with iron; and unlike BP1, BP2 does not have aconitase activity.	Iron	169-173	Blood pressure QTL 2	Rattus norvegicus	96-99
7523370-9	1994	These data indicate that BP1 and BP2 are distinct proteins that have similar specificity for IRE binding and that function similarly in translation, but are regulated by iron via different mechanisms.	Iron	170-174	Blood pressure QTL 1	Rattus norvegicus	25-28
7523370-9	1994	These data indicate that BP1 and BP2 are distinct proteins that have similar specificity for IRE binding and that function similarly in translation, but are regulated by iron via different mechanisms.	Iron	170-174	Blood pressure QTL 2	Rattus norvegicus	33-36
11313346-2	2001	The translation of many iron proteins is controlled by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem loop structures, known as iron-responsive elements (IREs), found in the untranslated regions of their mRNAs.	Iron	96-100	aconitase 1	Homo sapiens	129-133
11313346-3	2001	In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor).	Iron	15-19	aconitase 1	Homo sapiens	33-37
11313346-3	2001	In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor).	Iron	110-114	aconitase 1	Homo sapiens	33-37
7520477-1	1994	Recently, it was reported that nitric oxide (NO) directly controls intracellular iron metabolism by activating iron regulatory protein (IRP), a cytoplasmic protein that regulates ferritin translation.	Iron	81-85	wingless-type MMTV integration site family, member 2	Mus musculus	111-134
11313346-3	2001	In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor).	Iron	110-114	aconitase 1	Homo sapiens	33-37
7520477-1	1994	Recently, it was reported that nitric oxide (NO) directly controls intracellular iron metabolism by activating iron regulatory protein (IRP), a cytoplasmic protein that regulates ferritin translation.	Iron	81-85	wingless-type MMTV integration site family, member 2	Mus musculus	136-139
11313346-13	2001	These results suggest that the 75-kDa Fe-S subunit of mitochondrial Complex I may be regulated by a novel IRE-IRP system.	Iron	38-42	Wnt family member 2	Homo sapiens	110-113
11917720-2	2001	BACKGROUND: HFE-associated hemochromatosis is one of the most common inherited liver disease in Caucasian populations and refers to the association of increased iron stores with tissue damage (e.g., cirrhosis, diabetes, cardiomyopathy), which is progressive when diagnosis and treatment are delayed.	Iron	161-165	homeostatic iron regulator	Homo sapiens	12-15
8074667-7	1994	Iron depletion is however completely reversed 24 h later when maximal TRF-R upregulation occurs in IFN alpha-treated cells.	Iron	0-4	transferrin receptor	Homo sapiens	70-75
8074667-8	1994	We suggest that IFN alpha-induced iron depletion elicits a homeostatic cellular response through upregulation of TRF-R.	Iron	34-38	transferrin receptor	Homo sapiens	113-118
11418796-0	2001	A Chinese patient with non-HFE-linked iron overload.	Iron	38-42	homeostatic iron regulator	Homo sapiens	27-30
8060972-5	1994	This rate is unchanged in Fe-SA/B-depleted PS1 but is lost when the iron-sulfur center Fe-Sx is removed.	Iron	68-72	presenilin 1	Homo sapiens	43-46
11301321-10	2001	In parallel with its inhibition of vaccinia RR activation, BIP treatment increased the RNA binding activity of the endogenous iron-response protein, IRP1, by 1.9-fold.	Iron	126-130	aconitase 1	Homo sapiens	149-153
8070415-1	1994	Translation of ferritin and erythroid 5-aminolevulinate synthase (eALAS) mRNAs is regulated by iron via mRNA-protein interactions between iron-responsive elements (IREs) and iron regulatory protein (IRP).	Iron	95-99	Wnt family member 2	Homo sapiens	174-197
8070415-1	1994	Translation of ferritin and erythroid 5-aminolevulinate synthase (eALAS) mRNAs is regulated by iron via mRNA-protein interactions between iron-responsive elements (IREs) and iron regulatory protein (IRP).	Iron	95-99	Wnt family member 2	Homo sapiens	199-202
8070415-1	1994	Translation of ferritin and erythroid 5-aminolevulinate synthase (eALAS) mRNAs is regulated by iron via mRNA-protein interactions between iron-responsive elements (IREs) and iron regulatory protein (IRP).	Iron	138-142	Wnt family member 2	Homo sapiens	199-202
11389698-10	2001	In BeWo cells made iron deficient by treatment with desferrioxamine ("deferioxamine"), iron accumulation from iron-transferrin increased, in parallel with increased expression of the transferrin receptor.	Iron	19-23	transferrin receptor	Homo sapiens	183-203
8070415-2	1994	In iron-depleted cells, IRP binds to single IREs located in the 5" untranslated regions of ferritin and eALAS mRNAs and represses translation initiation.	Iron	3-7	Wnt family member 2	Homo sapiens	24-27
11264285-2	2001	Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin.	Iron	9-13	transferrin receptor	Mus musculus	183-203
8035833-8	1994	The mip1 mutant exhibited defects of complexes III and IV of the respiratory chain, caused by failure to carry out the second MIP-catalyzed cleavage of the nuclear-encoded precursors for cytochrome oxidase subunit IV (CoxIV) and the iron-sulfur protein (Fe-S) of the bc1 complex to mature proteins.	Iron	254-256	regulatory associated protein of MTOR complex 1	Homo sapiens	4-8
11264285-2	2001	Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin.	Iron	9-13	transferrin receptor	Mus musculus	205-208
8034647-7	1994	Before the release of urate from the molybdenum active site, an electron is transferred at 15 s-1 from the reduced molybdenum center to one of the iron-sulfur centers of XDH.	Iron	147-151	xanthine dehydrogenase	Homo sapiens	170-173
11264285-2	2001	Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin.	Iron	75-79	transferrin receptor	Mus musculus	183-203
11264285-2	2001	Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin.	Iron	75-79	transferrin receptor	Mus musculus	205-208
7518918-1	1994	The iron responsive element binding protein (IRE-BP) regulates iron storage and uptake in response to iron.	Iron	4-8	aconitase 1	Homo sapiens	45-51
7518918-1	1994	The iron responsive element binding protein (IRE-BP) regulates iron storage and uptake in response to iron.	Iron	63-67	aconitase 1	Homo sapiens	4-43
7518918-1	1994	The iron responsive element binding protein (IRE-BP) regulates iron storage and uptake in response to iron.	Iron	63-67	aconitase 1	Homo sapiens	45-51
7518918-2	1994	This control results from the interaction of the IRE-BP with the iron responsive element (IRE), a conserved sequence/structure element located near the 5" end of all ferritin mRNAs and in the 3" UTR of transferrin receptor mRNAs.	Iron	65-69	aconitase 1	Homo sapiens	49-55
11264285-3	2001	Under conditions of iron starvation, both IRP1 and IRP2 bind with high affinity to cognate IREs, thus stabilizing TfR and inhibiting translation of ferritin mRNAs.	Iron	20-24	transferrin receptor	Mus musculus	114-117
11264285-7	2001	Second, treatment with H(2)O(2) induces a approximately 4-fold increase in TfR mRNA levels within 2-6 h, and subsequent accumulation of newly synthesized protein after 4 h. This is associated with a profound increase in the cell surface expression of TfR, enhanced binding to fluorescein-tagged transferrin, and stimulation of transferrin-mediated iron uptake into cells.	Iron	348-352	transferrin receptor	Mus musculus	251-254
11368792-13	2001	Furthermore, treatment of cells with sodium arsenite increased levels of haem oxygenase concomitant with a marked decrease of spectrally detectable CYP2D6 and a rise in levels of ferritin, which sequesters free iron released from the destruction of haem.	Iron	211-215	ferritin, mitochondrial	Cricetulus griseus	179-187
8031836-3	1994	Each of these spectra demonstrate that the iron of heme bound by hemopexin is paramagnetic and low-spin.	Iron	43-47	HEME	Bos taurus	51-55
7959592-1	1994	Intracellular iron homeostasis is modulated by ferritin and transferrin receptor (TfR).	Iron	14-18	transferrin receptor	Homo sapiens	60-80
11436126-1	2001	Hereditary haemochromatosis is an inherited disorder characterised by an excessive iron absorption from the diet and is associated with several HFE gene mutations.	Iron	83-87	homeostatic iron regulator	Homo sapiens	144-147
7959592-1	1994	Intracellular iron homeostasis is modulated by ferritin and transferrin receptor (TfR).	Iron	14-18	transferrin receptor	Homo sapiens	82-85
7959592-3	1994	In spite of the important role of IRE/IRE-BP interaction for cellular iron metabolism, the role of it for erythroid differentiation is not yet well known.	Iron	70-74	aconitase 1	Homo sapiens	38-44
7959592-6	1994	The addition of excess iron (as 100 micrograms/ml holo transferrin) caused reduction of the level of TfR mRNA, however, the iron chelator defferoxamine caused its increase.	Iron	23-27	transferrin receptor	Homo sapiens	101-104
7959592-9	1994	The addition of iron or iron chelator both caused marked increase in the binding activity of IRE-BP at 48 hr after Na-butyrate treatment.	Iron	16-20	aconitase 1	Homo sapiens	93-99
7959592-9	1994	The addition of iron or iron chelator both caused marked increase in the binding activity of IRE-BP at 48 hr after Na-butyrate treatment.	Iron	24-28	aconitase 1	Homo sapiens	93-99
11436126-10	2001	The mean serum iron and ferritin levels were significantly higher in individuals with the HFE mutations than in normal cases.	Iron	15-19	homeostatic iron regulator	Homo sapiens	90-93
11389189-6	2001	IFN-beta decreased HO-1 expression and mitochondrial iron sequestration in IL-1beta- and TNF-alpha-challenged astroglia.	Iron	53-57	interferon beta 1	Homo sapiens	0-8
7981322-9	1994	In the third assay the iron complex of CP94, [Fe(III) (CP94)3] is quantified.	Iron	23-27	beaded filament structural protein 1	Homo sapiens	39-43
11389189-9	2001	In MS, IFN-beta may attenuate glial HO-1 gene induction and aberrant mitochondrial iron deposition accruing from exposure to proinflammatory cytokines.	Iron	83-87	interferon beta 1	Homo sapiens	7-15
11390682-4	2001	Transcription analysis showed that expression of pvdF was regulated by the amount of iron in the growth medium, consistent with its role in siderophore production.	Iron	85-89	pyoverdine synthetase F	Pseudomonas aeruginosa PAO1	49-53
8007965-2	1994	To determine if c-fps/fes can mediate the action of the colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) and to identify potential targets of c-fps/fes in macrophages, we have overexpressed c-fps/fes in a CSF-1-dependent macrophage cell line.	Iron	22-25	colony stimulating factor 1 receptor	Homo sapiens	85-100
8007965-2	1994	To determine if c-fps/fes can mediate the action of the colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) and to identify potential targets of c-fps/fes in macrophages, we have overexpressed c-fps/fes in a CSF-1-dependent macrophage cell line.	Iron	22-25	colony stimulating factor 1 receptor	Homo sapiens	102-109
16120268-1	2001	The yeast ATM1 protein is essential for normal mitochondrial iron homeostasis.	Iron	61-65	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	10-14
7975371-0	1994	[The role of iron ions in regulating aldose reductase activity in the cerebral cortex and retina in health rats and rats with hereditary retinal degeneration].	Iron	13-17	aldo-keto reductase family 1 member B1	Rattus norvegicus	37-53
16120268-2	2001	Deletion of ATM1 results in mitochondrial iron accumulation and oxidative mitochondrial damage.	Iron	42-46	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	12-16
16120268-4	2001	Here we show that a deletion of ATM1 also has effects on extra-mitochondrial iron metabolism.	Iron	77-81	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	32-36
8016074-0	1994	Molecular basis of a null mutation in soybean lipoxygenase 2: substitution of glutamine for an iron-ligand histidine.	Iron	95-99	seed linoleate 9S-lipoxygenase-2	Glycine max	46-60
16120268-5	2001	ATM1-deficient cells have an increased iron requirement for growth.	Iron	39-43	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	0-4
16120268-7	2001	Thus, ATM1 mutant cells simultaneously demonstrate features of both iron overload and iron starvation.	Iron	68-72	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	6-10
16120268-7	2001	Thus, ATM1 mutant cells simultaneously demonstrate features of both iron overload and iron starvation.	Iron	86-90	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	6-10
8031737-8	1994	Because the concentrations of Cu in plasma and bile, and also plasma ceruloplasmin (EC 1.16.3.1) activities, showed much greater percentage reductions with increasing Fe intake than did the concentrations of Cu in organs, it is possible that increased Fe status interferes with the mobilization of Cu stores.	Iron	167-169	ceruloplasmin	Rattus norvegicus	69-82
11497259-1	2001	Transferrin receptor expression is controlled by the amount of iron required by the cell to maintain its metabolism and therefore tumor cells in a highly proliferative state have a high density of transferrin receptors.	Iron	63-67	transferrin receptor	Homo sapiens	0-20
11313265-2	2001	The impact of HFE on iron transport was examined in B-lymphoid cell lines developed from a patient with hemochromatosis with the HFE C282Y mutation (C282Y cells) and an individual with the wild-type HFE gene (WT cells).	Iron	21-25	homeostatic iron regulator	Homo sapiens	14-17
8204590-1	1994	The proximal bond between the iron atom of the heme group and the N epsilon of histidine F8 in myoglobin (Mb) and hemoglobin (Hb) is presumed to be an important determinant of heme binding, protein structure, and oxygen binding.	Iron	30-34	myoglobin	Physeter catodon	95-104
8200339-0	1994	Analysis of cytochrome-b amino acid residues forming the contact face with the iron-sulfur subunit of ubiquinol:cytochrome-c reductase in Saccharomyces cerevisiae.	Iron	79-83	cytochrome b	Saccharomyces cerevisiae S288C	12-24
11313265-11	2001	Our results indicate that in this B-lymphoid cell line, the HFE C282Y mutation affects both Tf-dependent and -independent iron uptake and enhances cell sensitivity to oxidative stress.	Iron	122-126	homeostatic iron regulator	Homo sapiens	60-63
8167347-2	1994	At a concentration of 1.0 mmol/L, all three iron chelators were equally efficient in removing iron and restoring the activity of the thiolic sarcolemmal enzymes 5"-nucleotidase and Na,K,ATPase.	Iron	44-48	5' nucleotidase, ecto	Rattus norvegicus	161-176
11313265-12	2001	The role of HFE in iron uptake by B cells may extend beyond its known interaction with the TfR.	Iron	19-23	homeostatic iron regulator	Homo sapiens	12-15
11344112-0	2001	HFE inhibits apical iron uptake by intestinal epithelial (Caco-2) cells.	Iron	20-24	homeostatic iron regulator	Homo sapiens	0-3
8200081-8	1994	The iron-specific chelator desferal blocked ODC induction by BHTOOH, indicating that formation of this intermediate is iron-dependent.	Iron	4-8	ornithine decarboxylase 1	Homo sapiens	44-47
8200081-8	1994	The iron-specific chelator desferal blocked ODC induction by BHTOOH, indicating that formation of this intermediate is iron-dependent.	Iron	119-123	ornithine decarboxylase 1	Homo sapiens	44-47
11313310-1	2001	BACKGROUND &amp; AIMS: Stimulator of Fe Transport (SFT) and transferrin receptor (TfR) are proteins involved in iron transport.	Iron	112-116	ubiquitin conjugating enzyme E2 D1	Homo sapiens	23-49
7909515-2	1994	When a human plasma-cytoma cell line (ARH-77) is treated with an iron source (hemin), the TfR mRNA is destabilized and a shorter TfR RNA appears.	Iron	65-69	transferrin receptor	Homo sapiens	90-93
11313310-1	2001	BACKGROUND &amp; AIMS: Stimulator of Fe Transport (SFT) and transferrin receptor (TfR) are proteins involved in iron transport.	Iron	112-116	transferrin receptor	Homo sapiens	60-80
7909515-2	1994	When a human plasma-cytoma cell line (ARH-77) is treated with an iron source (hemin), the TfR mRNA is destabilized and a shorter TfR RNA appears.	Iron	65-69	transferrin receptor	Homo sapiens	129-132
7909515-3	1994	A similar phenomenon is also observed in mouse fibroblasts expressing a previously characterized iron-regulated human TfR mRNA (TRS-1).	Iron	97-101	transferrin receptor	Homo sapiens	118-121
11313310-1	2001	BACKGROUND &amp; AIMS: Stimulator of Fe Transport (SFT) and transferrin receptor (TfR) are proteins involved in iron transport.	Iron	112-116	transferrin receptor	Homo sapiens	82-85
7909515-4	1994	In contrast, mouse cells expressing a constitutively unstable human TfR mRNA (TRS-4) display the shorter RNA irrespective of iron treatment.	Iron	125-129	transferrin receptor	Homo sapiens	68-71
7909515-7	1994	The cleavage site of the human TfR mRNA in the mouse fibroblasts has been mapped to single nucleotide resolution to a single-stranded region near one of the iron-responsive elements contained in the 3" UTR.	Iron	157-161	transferrin receptor	Homo sapiens	31-34
11313310-6	2001	Its expression increased in anemics and, to a lesser degree, in HFE-related hemochromatotics, whereas it was reduced in patients with non-HFE-related iron overload.	Iron	150-154	homeostatic iron regulator	Homo sapiens	138-141
11313310-8	2001	TfR expression was intermediate in HFE-related hemochromatotics and similar to controls in non-HFE-related iron overload.	Iron	107-111	transferrin receptor	Homo sapiens	0-3
11313310-8	2001	TfR expression was intermediate in HFE-related hemochromatotics and similar to controls in non-HFE-related iron overload.	Iron	107-111	homeostatic iron regulator	Homo sapiens	95-98
11313310-10	2001	Increased expression of both proteins is present only in HFE-related hemochromatotics suggesting that other factors may be involved in determining non-HFE-related iron overload phenotype.	Iron	163-167	homeostatic iron regulator	Homo sapiens	151-154
8144605-1	1994	The H(+)-ATPase from reticulocyte endosomes was purified and reconstituted into liposomes, and protein-dependent iron transport was observed.	Iron	113-117	dynein axonemal heavy chain 8	Homo sapiens	9-15
8144605-4	1994	Upon addition of ascorbate, an initial efflux of 2.9 +/- 0.3 x 10(-2) mumol of iron/mg of ATPase/min and 56 +/-7% of total internal Fe(II) was detected by formation of the Fe(II)-FerroZine complex with an absorbance at 562 nm or radioactivity of 59Fe(II)-FerroZine following separation using gel filtration.	Iron	79-83	dynein axonemal heavy chain 8	Homo sapiens	90-96
11334672-9	2001	These findings suggest that Hfe has an effect in the shaping of T-cell populations either directly, as indicated by the lymphopenia seen in the two chains in C282Y heterozygous without iron overload, or indirectly by contributing to iron overload pathology.	Iron	185-189	homeostatic iron regulator	Homo sapiens	28-31
8144605-8	1994	The amount of iron transported was decreased 51 or 39% by 100 microM N,N"-dicyclohexylcarbodiimide or 70 microM of the ATPase inhibitor 7-chloro-4-nitrobenz-2-oxa-1,3-diazole.	Iron	14-18	dynein axonemal heavy chain 8	Homo sapiens	119-125
8144605-10	1994	These results suggest that this vacuolar H(+)-ATPase may transport iron.	Iron	67-71	dynein axonemal heavy chain 8	Homo sapiens	46-52
8143723-2	1994	In proliferating non-erythroid cells, the expression of transferrin receptors (TfR) is negatively regulated by the amount of intracellular iron.	Iron	139-143	transferrin receptor	Mus musculus	56-77
11334672-9	2001	These findings suggest that Hfe has an effect in the shaping of T-cell populations either directly, as indicated by the lymphopenia seen in the two chains in C282Y heterozygous without iron overload, or indirectly by contributing to iron overload pathology.	Iron	233-237	homeostatic iron regulator	Homo sapiens	28-31
8143723-2	1994	In proliferating non-erythroid cells, the expression of transferrin receptors (TfR) is negatively regulated by the amount of intracellular iron.	Iron	139-143	transferrin receptor	Mus musculus	79-82
8143723-3	1994	Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA.	Iron	0-2	transferrin receptor	Mus musculus	27-30
11336795-0	2001	The effects of wild-type and mutant HFE expression upon cellular iron uptake in transfected human embryonic kidney cells.	Iron	65-69	homeostatic iron regulator	Homo sapiens	36-39
8143723-3	1994	Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA.	Iron	0-2	transferrin receptor	Mus musculus	156-159
8143723-3	1994	Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA.	Iron	80-84	transferrin receptor	Mus musculus	27-30
8143723-3	1994	Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA.	Iron	80-84	transferrin receptor	Mus musculus	156-159
8143723-9	1994	(c) Following induction of MEL cells, there is an increase in the stability of TfR mRNA, whose level is only slightly affected by iron excess.	Iron	130-134	transferrin receptor	Mus musculus	79-82
11336795-11	2001	The results show that HFE reduces transferrin-iron uptake, probably as an uncompetitive inhibitor.	Iron	46-50	homeostatic iron regulator	Homo sapiens	22-25
8119990-2	1994	Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE).	Iron	54-58	transferrin receptor	Rattus norvegicus	0-20
8119990-2	1994	Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE).	Iron	54-58	transferrin receptor	Rattus norvegicus	22-25
8119990-2	1994	Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE).	Iron	144-148	transferrin receptor	Rattus norvegicus	0-20
8119990-2	1994	Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE).	Iron	144-148	transferrin receptor	Rattus norvegicus	22-25
11292861-2	2001	In oxygenated and iron replete cells, HIF-alpha subunits are rapidly destroyed by a mechanism that involves ubiquitylation by the von Hippel-Lindau tumor suppressor (pVHL) E3 ligase complex.	Iron	18-22	von Hippel-Lindau tumor suppressor	Homo sapiens	166-170
8308003-7	1994	It was found that the heme- or iron-dependent disappearance of 98-kDa IRE-BP occurred rapidly (within 1 h), and was equally rapidly reversed upon removal of heme after a 1-h exposure.	Iron	31-35	aconitase 1	Homo sapiens	70-76
11300792-3	2001	The present RR investigation of the Fe coordination and heme pocket environments of ferrous, carbonyl, and nitrosyl forms of cytochrome c" in solution fully supports the structures determined by X-ray crystallography and offers insights into mechanisms of ligand discrimination in heme-based sensors.	Iron	36-38	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	125-137
8181736-1	1994	Transferrin, the iron transport protein of the blood, is highly polymorphic in many species, including the horse.	Iron	17-21	inhibitor of carbonic anhydrase	Equus caballus	0-11
8013958-0	1994	Iron overload in beta 2-microglobulin-deficient mice.	Iron	0-4	beta-2 microglobulin	Mus musculus	17-37
11579422-4	2001	There are diseases caused by nuclear genes encoding non-OXPHOS mitochondrial proteins, such as frataxin in Friedreich ataxia (which is likely to play an important role in mitochondrial-cytosolic iron cycling), paraplegin (possibly a mitochondrial ATP-dependent zinc metalloprotease of the AAA-ATPases in hereditary spastic paraparesis), and possibly Wilson disease protein (an abnormal copper transporting ATP-dependent P-type ATPase associated with Wilson disease).	Iron	195-199	frataxin	Homo sapiens	95-103
8013958-1	1994	The present paper describes the results of a comparative histological and quantitative analysis of iron distribution in tissues of beta 2m-/- and beta 2m+/- mice of different ages.	Iron	99-103	beta-2 microglobulin	Mus musculus	131-141
8013958-1	1994	The present paper describes the results of a comparative histological and quantitative analysis of iron distribution in tissues of beta 2m-/- and beta 2m+/- mice of different ages.	Iron	99-103	beta-2 microglobulin	Mus musculus	131-138
8013958-2	1994	Progressive hepatic iron overload, indistinguishable from that observed in human hemochromatosis, was found only in mice homozygous for the mutated beta 2m gene.	Iron	20-24	beta-2 microglobulin	Mus musculus	148-155
11306436-6	2001	The AOS scavenger tetramethylthiourea or treatment of fibers with the iron chelator deferoxamine prevented asbestos-induced increases in procollagen, PDGF-A, and TGF-beta gene expression, whereas glutathione had no effect.	Iron	70-74	platelet derived growth factor subunit A	Rattus norvegicus	150-156
8087243-7	1994	This injury is dependent on the iron content of heme and is completely blocked when concomitant hemopexin is added.	Iron	32-36	hemopexin	Homo sapiens	96-105
11306436-9	2001	Surface iron and AOS also play a role in PDGF-A and TGF-beta gene expression, but through an ERK-dependent mechanism.	Iron	8-12	platelet derived growth factor subunit A	Rattus norvegicus	41-47
11113132-4	2001	In addition, beta(2)-microglobulin knockout mice fed with a low iron content diet exhibited a decrease of hepatic mRNA expression.	Iron	64-68	beta-2 microglobulin	Mus musculus	13-34
11280588-1	2001	al.--Histological evaluation of iron in liver biopsies: relationship to HFE mutations.	Iron	32-36	homeostatic iron regulator	Homo sapiens	72-75
11280947-1	2001	PURPOSE: The recent discovery of the HFE gene and its association with hereditary hemochromatosis has renewed the attention directed to iron-overload diseases.	Iron	136-140	homeostatic iron regulator	Homo sapiens	37-40
11326747-6	2001	Our results suggest distinct roles for IRP1 and IRP2 in the regulation of iron homeostasis in the mammalian nervous system where IRP1 may provide a maintenance function in contrast to IRP2 that could participate in modulating proper CAN functions, including cardiopulmonary, gustatory as well as fine motor control.	Iron	74-78	aconitase 1	Homo sapiens	39-43
11277235-7	2001	The Fe-N bond length increases by about 0.02 A for the sample with 15.3% HbA1c compared with the others, but the Fe-O bond length is almost unchanged.	Iron	4-8	hemoglobin subunit alpha 1	Homo sapiens	73-77
11421105-0	2001	Heterozygosity for the H63D mutation in the hereditary hemochromatosis (HFE) gene may lead into severe iron overload in beta-thalassemia minor: observations in a thalassemic kindred.	Iron	103-107	homeostatic iron regulator	Homo sapiens	72-75
11421105-2	2001	We describe here a kindred in which the propositus, being heterozygote for beta-thalassemia and the H63D mutation of the HFE gene, developed severe iron overload and in turn, chronic liver failure with portal hypertension.	Iron	148-152	homeostatic iron regulator	Homo sapiens	121-124
11469076-1	2001	OBJECTIVE: To test the hypothesis that the heterozygous state for HFE gene mutations involved in the pathogenesis of hemochromatosis, that may induce an increase of hepatic iron content, may aggravate the liver damage induced by prolonged and excessive use of ethanol.	Iron	173-177	homeostatic iron regulator	Homo sapiens	66-69
11361003-1	2001	The transferrin receptor (TfR) is a N- and O-glycosylated transmembrane protein mediating the cellular iron uptake by binding and internalization of diferric transferrin.	Iron	103-107	transferrin receptor	Homo sapiens	4-24
11361003-1	2001	The transferrin receptor (TfR) is a N- and O-glycosylated transmembrane protein mediating the cellular iron uptake by binding and internalization of diferric transferrin.	Iron	103-107	transferrin receptor	Homo sapiens	26-29
11159767-1	2001	BACKGROUND: Heterozygotes for the C282Y mutation of the HFE gene may have altered hematology indices and higher iron stores than wild-type subjects.	Iron	112-116	homeostatic iron regulator	Homo sapiens	56-59
11563695-0	2001	Effects of reduction and ligation of heme iron on the thermal stability of heme-hemopexin complexes.	Iron	42-46	hemopexin	Homo sapiens	80-89
11280607-1	2001	Iron overload has been proposed as a cause of liver dysfunction after BMT Factors which could be relevant to iron overload include the number of red cell transfusions and mutations within the haemochromatosis gene (HFE).	Iron	0-4	homeostatic iron regulator	Homo sapiens	215-218
11280607-1	2001	Iron overload has been proposed as a cause of liver dysfunction after BMT Factors which could be relevant to iron overload include the number of red cell transfusions and mutations within the haemochromatosis gene (HFE).	Iron	109-113	homeostatic iron regulator	Homo sapiens	215-218
11280607-10	2001	These cases demonstrate the variable phenotypic expression of HFE compound heterozygosity in BMT recipients, which may be only partly explained by transfusional iron loading.	Iron	161-165	homeostatic iron regulator	Homo sapiens	62-65
11310426-14	2001	Studies of genetic variants in HFE and other regulatory proteins provide important tools for studying the biological processes in Fe regulation.	Iron	130-132	homeostatic iron regulator	Homo sapiens	31-34
11146451-2	2001	We have studied the effect of orally administered iron-unsaturated bovine Lf on angiogenesis induced by VEGF(165) and IL-1-alpha in adult rats using the mesenteric-window angiogenesis assay.	Iron	50-54	interleukin 1 alpha	Bos taurus	118-128
11358396-0	2001	The hHFE gene of browsing and grazing rhinoceroses: a possible site of adaptation to a low-iron diet.	Iron	91-95	homeostatic iron regulator	Homo sapiens	4-8
11358396-3	2001	In humans, mutations of the HFE gene cause increased iron absorption.	Iron	53-57	homeostatic iron regulator	Homo sapiens	28-31
11427444-4	2001	The protein product of the HFE gene is a transmembrane glycoprotein, termed HFE, that modulates iron uptake.	Iron	96-100	homeostatic iron regulator	Homo sapiens	27-30
7834273-1	1994	Hereditary hemochromatosis (HFE) is an inherited recessive disorder which causes progressive iron overload.	Iron	93-97	homeostatic iron regulator	Homo sapiens	28-31
8156052-5	1994	Our results demonstrate that transferrin-binding protein 2 (TBP2) is immunogenic in humans, to varying degrees depending on the strain, and that TBP2s (like the equivalent proteins of Haemophilus influenzae type b) are among the most important iron-regulated outer membrane antigens expressed during infection.	Iron	244-248	TATA-box binding protein like 2	Homo sapiens	29-58
8156052-5	1994	Our results demonstrate that transferrin-binding protein 2 (TBP2) is immunogenic in humans, to varying degrees depending on the strain, and that TBP2s (like the equivalent proteins of Haemophilus influenzae type b) are among the most important iron-regulated outer membrane antigens expressed during infection.	Iron	244-248	TATA-box binding protein like 2	Homo sapiens	145-149
7883473-5	1994	In the first experiment, indices of iron status were significantly higher in HFe rats and in females compared with males.	Iron	36-40	homeostatic iron regulator	Rattus norvegicus	77-80
7883473-8	1994	The second experiment confirmed the higher indices of iron status in HFe rats and in female rats, and also showed that plasma cholesterol levels were significantly higher in HFe rats.	Iron	54-58	homeostatic iron regulator	Rattus norvegicus	69-72
8262329-5	1993	This has led to the realization that IRE-BP is an alternative form of cytosolic (not of mitochondrial) aconitase that is devoid of its cubane Fe-S cluster.	Iron	142-146	aconitase 1	Homo sapiens	37-43
8412298-1	1993	The level of iron responsive element-binding protein (IRE-BP) in leukemic cells, which is essential for iron homeostasis and plays an important role in cell metabolism and cell growth, was measured using an enzyme-linked immunosorbent assay (ELISA).	Iron	13-17	aconitase 1	Homo sapiens	54-60
8364209-5	1993	Inhibition of proliferation by Tf-Ga is associated with decreased cellular Fe incorporation.	Iron	75-77	transforming growth factor alpha	Homo sapiens	31-36
8349646-0	1993	Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.	Iron	23-27	aconitase 1	Homo sapiens	67-106
8349646-1	1993	The iron-responsive element-binding protein (IRE-BP) binds to specific RNA stem-loop structures called iron-responsive elements (IREs), which mediate the post-transcriptional regulation of a variety of genes involved in iron metabolism.	Iron	4-8	aconitase 1	Homo sapiens	45-51
8349646-1	1993	The iron-responsive element-binding protein (IRE-BP) binds to specific RNA stem-loop structures called iron-responsive elements (IREs), which mediate the post-transcriptional regulation of a variety of genes involved in iron metabolism.	Iron	103-107	aconitase 1	Homo sapiens	4-43
8349646-1	1993	The iron-responsive element-binding protein (IRE-BP) binds to specific RNA stem-loop structures called iron-responsive elements (IREs), which mediate the post-transcriptional regulation of a variety of genes involved in iron metabolism.	Iron	103-107	aconitase 1	Homo sapiens	45-51
8349646-3	1993	Chemical modification of the IRE-BP can abrogate RNA binding and the 3 cysteines predicted to coordinate the Fe-S cluster in the IRE-BP could be targets for modification.	Iron	109-113	aconitase 1	Homo sapiens	29-35
8349646-3	1993	Chemical modification of the IRE-BP can abrogate RNA binding and the 3 cysteines predicted to coordinate the Fe-S cluster in the IRE-BP could be targets for modification.	Iron	109-113	aconitase 1	Homo sapiens	129-135
8347616-6	1993	A spectrofluorometric method was developed to monitor release of iron from C-terminal monoferric human transferrin and its complex with the transferrin receptor.	Iron	65-69	transferrin receptor	Homo sapiens	140-160
8347143-7	1993	In conclusion, these results suggest an important role for iron in porphyrin accumulation, probably through its catalytic role in the generation of oxygen-related free radicals, resulting in direct damage to URO-D.	Iron	59-63	uroporphyrinogen decarboxylase	Mus musculus	208-213
8514748-2	1993	In addition, TfR mRNA is post-transcriptionally regulated by intracellular iron.	Iron	75-79	transferrin receptor	Mus musculus	13-16
8514748-3	1993	Low iron levels activate a cytoplasmic RNA-binding protein, called iron regulatory factor (IRF) or iron-responsive element-binding protein, which coordinately stabilizes TfR mRNA and inhibits ferritin mRNA translation.	Iron	4-8	transferrin receptor	Mus musculus	170-173
8514748-3	1993	Low iron levels activate a cytoplasmic RNA-binding protein, called iron regulatory factor (IRF) or iron-responsive element-binding protein, which coordinately stabilizes TfR mRNA and inhibits ferritin mRNA translation.	Iron	67-71	transferrin receptor	Mus musculus	170-173
8514748-11	1993	Our results indicate that expression of TfR, like ferritin, is controlled by both iron and cytokines.	Iron	82-86	transferrin receptor	Mus musculus	40-43
8509412-1	1993	The transferrin receptor is a cell surface protein and is responsible for the uptake of iron into many eukaryotic cells.	Iron	88-92	transferrin receptor	Homo sapiens	4-24
8389362-2	1993	Optical spectra of mitochondrial membranes from yeast in which the gene for subunit 9 is deleted show a diminution of cytochrome b absorption similar to the spectra of membranes from yeast in which the gene for the Rieske iron-sulfur protein is deleted, suggesting an interaction between subunit 9, iron-sulfur protein, and cytochrome b.	Iron	222-226	cytochrome b	Saccharomyces cerevisiae S288C	118-130
8389362-7	1993	These results suggest that in the absence of subunit 9 the conformation of iron-sulfur protein is altered such that the protein is more labile, the iron-sulfur cluster is not properly inserted, and iron-sulfur protein interaction with cytochrome b is modified in a manner which distorts the heme environment.	Iron	75-79	cytochrome b	Saccharomyces cerevisiae S288C	235-247
8389362-7	1993	These results suggest that in the absence of subunit 9 the conformation of iron-sulfur protein is altered such that the protein is more labile, the iron-sulfur cluster is not properly inserted, and iron-sulfur protein interaction with cytochrome b is modified in a manner which distorts the heme environment.	Iron	148-152	cytochrome b	Saccharomyces cerevisiae S288C	235-247
8389362-7	1993	These results suggest that in the absence of subunit 9 the conformation of iron-sulfur protein is altered such that the protein is more labile, the iron-sulfur cluster is not properly inserted, and iron-sulfur protein interaction with cytochrome b is modified in a manner which distorts the heme environment.	Iron	148-152	cytochrome b	Saccharomyces cerevisiae S288C	235-247
8394320-1	1993	The iron-sulfur protein of the cytochrome bc1 complex oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism, transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group.	Iron	4-8	cytochrome b	Saccharomyces cerevisiae S288C	31-43
8504171-4	1993	The horse transferrin sequence had the duplicated structure and conserved iron binding and cysteine residues which are characteristic of the transferrin family.	Iron	74-78	inhibitor of carbonic anhydrase	Equus caballus	10-21
8504171-4	1993	The horse transferrin sequence had the duplicated structure and conserved iron binding and cysteine residues which are characteristic of the transferrin family.	Iron	74-78	inhibitor of carbonic anhydrase	Equus caballus	141-152
8504641-6	1993	In the cytosol of the frog liver cells, seasonal changes of MPST specific activity seemed to be related to the production of mitochondrial iron-sulphur protein and to the protein-dependent metabolism during the fasting period.	Iron	139-143	mercaptopyruvate sulfurtransferase	Canis lupus familiaris	60-64
8518796-5	1993	The biochemical and genetic defects leading to progressive iron accumulation are still unknown, but the HFE gene is tightly linked to HLA complex on the short arm of chromosome 6.	Iron	59-63	homeostatic iron regulator	Homo sapiens	104-107
8463258-10	1993	Comparison with chicken ATase showed that 2 cysteine residues for an iron-sulfur cluster were conserved.	Iron	69-73	phosphoribosyl pyrophosphate amidotransferase	Gallus gallus	24-29
8439591-10	1993	Using desferrioxamine it was shown that TfR expression is dependent on the biological availability of iron in the cell.	Iron	102-106	transferrin receptor	Homo sapiens	40-43
11427444-4	2001	The protein product of the HFE gene is a transmembrane glycoprotein, termed HFE, that modulates iron uptake.	Iron	96-100	homeostatic iron regulator	Homo sapiens	76-79
11642510-7	2001	The s-TfR levels in RA patients showed negative correlations with red blood cell count, serum iron level and haemoglobin concentration, and positive correlations with ESR and serum EPO levels.	Iron	94-98	transferrin receptor	Homo sapiens	6-9
8244202-4	1993	Recent data suggest that the chelatable intracellular iron pool regulates the expression of proteins with central importance in cellular iron metabolism (TfR, ferritin, and erythroid 5-aminolevulinic synthetase) in a coordinately controlled way through an iron dependent cytosolic mRNA binding protein, the iron regulating factor (IRF).	Iron	54-58	transferrin receptor	Homo sapiens	154-157
8244202-4	1993	Recent data suggest that the chelatable intracellular iron pool regulates the expression of proteins with central importance in cellular iron metabolism (TfR, ferritin, and erythroid 5-aminolevulinic synthetase) in a coordinately controlled way through an iron dependent cytosolic mRNA binding protein, the iron regulating factor (IRF).	Iron	137-141	transferrin receptor	Homo sapiens	154-157
8244202-4	1993	Recent data suggest that the chelatable intracellular iron pool regulates the expression of proteins with central importance in cellular iron metabolism (TfR, ferritin, and erythroid 5-aminolevulinic synthetase) in a coordinately controlled way through an iron dependent cytosolic mRNA binding protein, the iron regulating factor (IRF).	Iron	137-141	transferrin receptor	Homo sapiens	154-157
8244202-4	1993	Recent data suggest that the chelatable intracellular iron pool regulates the expression of proteins with central importance in cellular iron metabolism (TfR, ferritin, and erythroid 5-aminolevulinic synthetase) in a coordinately controlled way through an iron dependent cytosolic mRNA binding protein, the iron regulating factor (IRF).	Iron	137-141	transferrin receptor	Homo sapiens	154-157
11168438-9	2001	CONCLUSION: The results indicate that HH patients with the HFE C282Y mutation and low numbers of CD8+ cells in the liver lobuli have higher iron stores and are more prone to develop liver cirrhosis.	Iron	140-144	homeostatic iron regulator	Homo sapiens	59-62
8354570-0	1993	Urinary N-acetyl-beta-D-glucosaminidase and beta-aminoisobutyric acid in workers occupationally exposed to metals such as chromium, nickel, and iron.	Iron	144-148	O-GlcNAcase	Homo sapiens	8-39
8354570-1	1993	To examine the relationships between the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and beta-aminoisobutyric acid (AIBA) as a metabolite of thymine, and exposure to chromium, nickel, and iron, we determined these parameters in 58 workers engaged in the cutting and grinding of stainless steel or iron-steel plates.	Iron	203-207	O-GlcNAcase	Homo sapiens	62-93
8354570-1	1993	To examine the relationships between the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and beta-aminoisobutyric acid (AIBA) as a metabolite of thymine, and exposure to chromium, nickel, and iron, we determined these parameters in 58 workers engaged in the cutting and grinding of stainless steel or iron-steel plates.	Iron	203-207	O-GlcNAcase	Homo sapiens	95-98
8354570-1	1993	To examine the relationships between the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and beta-aminoisobutyric acid (AIBA) as a metabolite of thymine, and exposure to chromium, nickel, and iron, we determined these parameters in 58 workers engaged in the cutting and grinding of stainless steel or iron-steel plates.	Iron	312-316	O-GlcNAcase	Homo sapiens	95-98
11167127-6	2001	Evidence that human frataxin is also involved in mitochondrial Fe-overload comes from studies in FA patients that have shown an accumulation of Fe within the heart.	Iron	63-65	frataxin	Homo sapiens	20-28
8426074-4	1993	Iron loading resulted in a sharp increase in the total activity of the lysosomal enzyme beta-hexosaminidase in unfractionated whole-cell homogenates, increased free enzyme activity, and loss of latent activity indicating increased lysosomal fragility.	Iron	0-4	O-GlcNAcase	Rattus norvegicus	88-107
11167127-6	2001	Evidence that human frataxin is also involved in mitochondrial Fe-overload comes from studies in FA patients that have shown an accumulation of Fe within the heart.	Iron	144-146	frataxin	Homo sapiens	20-28
11725764-1	2001	The regulation of transferrin receptor (RTF) is related to intracellular iron stores and with the soluble receptor is present in plasma.	Iron	73-77	transferrin receptor	Homo sapiens	18-38
11085915-3	2000	Iron homoeostasis is controlled through several genes, an increasing number of which have been found to contain non-coding sequences [i.e. the iron-responsive elements (IREs)] which are recognized at the mRNA level by two cytoplasmic iron-regulatory proteins (IRP-1 and IRP-2).	Iron	143-147	aconitase 1	Homo sapiens	260-265
11085915-5	2000	By means of an Fe-S-cluster-dependent switch, IRP-1 can function as an mRNA-binding protein or as an enzyme that converts citrate into isocitrate.	Iron	15-17	aconitase 1	Homo sapiens	46-51
11085915-8	2000	Conversely, various agents and conditions may affect IRP activity, thereby modulating iron and oxygen radical levels in different pathobiological settings.	Iron	86-90	Wnt family member 2	Homo sapiens	53-56
11111058-5	2000	This encodes the protein frataxin which regulates mitochondrial iron transport.	Iron	64-68	frataxin	Homo sapiens	25-33
11093725-6	2000	The HFE mutations were uncommon in patients with increased hepatic iron stores.	Iron	67-71	homeostatic iron regulator	Homo sapiens	4-7
11073924-9	2000	The identification of HemO as a heme oxygenase provides further evidence that oxidative cleavage of the heme is the mechanism by which some bacteria acquire iron for further use.	Iron	157-161	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	32-46
11169063-1	2000	BACKGROUND/AIMS: The effect of heterozygosity for the C282Y mutation in the HFE hemochromatosis gene on iron accumulation and disease progression in liver disease patients is unclear.	Iron	104-108	homeostatic iron regulator	Homo sapiens	76-79
11146662-0	2000	Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.	Iron	89-93	transferrin receptor	Homo sapiens	15-35
11146662-3	2000	Levels of the iron-storage protein ferritin are greatly reduced and those of TfR are slightly increased in cells expressing wild-type HFE, but not in cells expressing either mutant.	Iron	14-18	homeostatic iron regulator	Homo sapiens	134-137
11146662-5	2000	Thus, binding to TfR is required for transport of HFE to endosomes and regulation of intracellular iron homeostasis, but not for basolateral surface expression of HFE.	Iron	99-103	transferrin receptor	Homo sapiens	17-20
11140262-3	2000	We report here that about 40 J/cm2 of UVA are required to inactivate half of the binding capacity of apo-IRP-1 to iron responsive elements (IRE) of RNA whereas 15 J/cm2 already inhibit half of the holo-IRP-1 aconitase activity.	Iron	114-118	aconitase 1	Homo sapiens	105-110
11199371-1	2000	Excessive oral iron intake may lead to secondary hemochromatosis even in HFE C282Y mutation negative subjects.	Iron	15-19	homeostatic iron regulator	Homo sapiens	73-76
11099895-9	2000	The discovery of the HFE gene has also paved the road for the individualization of other types of iron overload syndromes which are not HFE-related.	Iron	98-102	homeostatic iron regulator	Homo sapiens	21-24
11113969-6	2000	ORF YLL051c (FRE6) shows similarity to iron transport proteins, such as ferric reductase.	Iron	39-43	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	13-17
11092755-4	2000	Moreover, upmodulation by deferoxamine mesylate implicates huntingtin as an iron-response protein.	Iron	76-80	huntingtin	Homo sapiens	59-69
11092755-6	2000	Thus, organelles that require huntingtin to function suggest roles for the protein in RNA biogenesis, trafficking and iron homeostasis to be explored in HD pathogenesis.	Iron	118-122	huntingtin	Homo sapiens	30-40
11078891-0	2000	Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells.	Iron	85-89	homeostatic iron regulator	Homo sapiens	34-37
11078891-0	2000	Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells.	Iron	85-89	transferrin receptor	Homo sapiens	47-67
11079015-4	2000	MATERIALS AND METHODS: In this study we analyzed the livers of 50 transplant patients with a diagnosis of either hepatitis C cirrhosis or cryptogenic cirrhosis for the prevalence of the more common C282Y mutation of the HFE gene and correlated the findings to hepatic iron concentration.	Iron	268-272	homeostatic iron regulator	Homo sapiens	220-223
11079015-10	2000	CONCLUSIONS: We conclude that patients with hepatitis C have an increased tendency to accumulate iron in the liver, and mutations in the HFE gene play a minor role in hepatic accumulation of iron in these patients.	Iron	191-195	homeostatic iron regulator	Homo sapiens	137-140
11050011-1	2000	The human protein ABC7 belongs to the adenosine triphosphate-binding cassette transporter superfamily, and its yeast orthologue, Atm1p, plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.	Iron	201-203	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	129-134
11110619-3	2000	A higher frequency of mutations of the HFE gene, the gene responsible for hereditary hemochromatosis, is found in patients with liver diseases and increased liver iron than in normal patients.	Iron	163-167	homeostatic iron regulator	Homo sapiens	39-42
11060020-5	2000	Biochemical analyses demonstrate that IscU proteins specifically associate with IscS, a cysteine desulfurase that is proposed to sequester inorganic sulfur for Fe-S cluster assembly.	Iron	160-162	NFS1 cysteine desulfurase	Homo sapiens	80-84
11060020-6	2000	Protein complexes containing IscU and IscS can be found in the mitochondria as well as in the cytosol, implying that Fe-S cluster assembly takes place in multiple subcellular compartments in mammalian cells.	Iron	117-121	NFS1 cysteine desulfurase	Homo sapiens	38-42
11111785-12	2000	There was mild iron deposition possibly related to an homozygous H63D mutation in the HFE gene.	Iron	15-19	homeostatic iron regulator	Homo sapiens	86-89
11109593-8	2000	FUTURE PROSPECTS AND PROJECTS: The discovery of the HFE gene has permitted hereditary hemochromatosis to be easily differentiated from other forms of hepatic iron overload including a new syndrome, dysmotabolic hepatosiderosis.	Iron	158-162	homeostatic iron regulator	Homo sapiens	52-55
11023834-10	2000	This was shown by the Fet4p-dependence of copper activation of Fet3p, the copper oxidase that supports high affinity iron uptake in yeast.	Iron	117-121	ferroxidase FET3	Saccharomyces cerevisiae S288C	63-68
10922376-8	2000	Elevated copper levels induced the expression of the metallothioneins CUP1 and CRS5 and two genes, FET3 and FTR1, in the iron uptake system.	Iron	121-125	ferroxidase FET3	Saccharomyces cerevisiae S288C	99-103
10922376-9	2000	Copper-induced FET3 and FTR1 expression arises from an indirect copper effect on cellular iron pools.	Iron	90-94	ferroxidase FET3	Saccharomyces cerevisiae S288C	15-19
8094018-1	1993	In the last two decades, many biological functions of iron have been identified, in particular its role in many enzymatic processes, its effect on dopamine D2 receptor function, its interaction with other neurotransmitters (gamma-aminobutyric acid, serotonin, opiate-peptides), and its catalytic role in the nonenzymatic mechanisms for oxidation, hydroxylation, and peroxidation reactions.	Iron	54-58	dopamine receptor D2	Homo sapiens	147-167
11030757-0	2000	Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae.	Iron	39-43	frataxin	Homo sapiens	6-14
8383350-4	1993	After the completion of iron loading, the biochemical measurements revealed elevation of alanine aminotransferase (ALT), slight reduction of plasma glucose concentration, and significant reduction of both plasma and liver ascorbic-acid levels.	Iron	24-28	glutamic--pyruvic transaminase	Homo sapiens	89-113
11030757-4	2000	Evidence of iron accumulation and oxidative damage in cardiac tissue from FRDA patients suggests that fxn may have a similar function, but whether yeast and human frataxin actually have interchangeable roles in mitochondrial iron homeostasis is unknown.	Iron	12-16	frataxin	Homo sapiens	74-78
11030757-5	2000	We show that a wild-type FRDA cDNA can complement Yfh1p-deficient yeast (yfh1 delta) by preventing the mitochondrial iron accumulation and oxidative damage associated with loss of Yfh1p.	Iron	117-121	frataxin	Homo sapiens	25-29
11030757-9	2000	Expression of the FRDA (W173G) cDNA in yfh1 delta yeast leads to increased levels of mitochondrial iron which are not as elevated as in Yfh1p-deficient cells but are above the threshold for oxidative damage of mitochondrial DNA and iron-sulfur centers, causing a typical yfh1 delta phenotype.	Iron	99-103	frataxin	Homo sapiens	18-22
11030757-9	2000	Expression of the FRDA (W173G) cDNA in yfh1 delta yeast leads to increased levels of mitochondrial iron which are not as elevated as in Yfh1p-deficient cells but are above the threshold for oxidative damage of mitochondrial DNA and iron-sulfur centers, causing a typical yfh1 delta phenotype.	Iron	232-236	frataxin	Homo sapiens	18-22
11030757-10	2000	These results demonstrate that fxn functions like Yfh1p, providing experimental support to the hypothesis that FRDA is a disorder of mitochondrial iron homeostasis.	Iron	147-151	frataxin	Homo sapiens	31-34
11030757-10	2000	These results demonstrate that fxn functions like Yfh1p, providing experimental support to the hypothesis that FRDA is a disorder of mitochondrial iron homeostasis.	Iron	147-151	frataxin	Homo sapiens	111-115
11196670-2	2000	The recent finding that a physical interaction between HFE and transferrin receptor establishes a functional link between HFE and transferrin receptor-mediated iron metabolism in the pathophysiology of hereditary hemochromatosis.	Iron	160-164	homeostatic iron regulator	Homo sapiens	55-58
11196670-2	2000	The recent finding that a physical interaction between HFE and transferrin receptor establishes a functional link between HFE and transferrin receptor-mediated iron metabolism in the pathophysiology of hereditary hemochromatosis.	Iron	160-164	homeostatic iron regulator	Homo sapiens	122-125
11196670-3	2000	To elucidate the underlying mechanisms by which HFE interacts with and affects transferrin receptor function, we have systematically investigated the consequences of the HFE-transferrin receptor interaction in cellular iron homeostasis.	Iron	219-223	homeostatic iron regulator	Homo sapiens	170-173
11196670-6	2000	As a result, HFE expression leads to an accumulation of non-functional transferrin receptors at the cell surface, and a decrease in iron uptake.	Iron	132-136	homeostatic iron regulator	Homo sapiens	13-16
11196670-8	2000	Taken together, these results suggest that HFE negatively modulates cellular iron uptake by impairing transferrin receptor endocytosis via HFE-induced receptor phosphorylation.	Iron	77-81	homeostatic iron regulator	Homo sapiens	43-46
11196670-8	2000	Taken together, these results suggest that HFE negatively modulates cellular iron uptake by impairing transferrin receptor endocytosis via HFE-induced receptor phosphorylation.	Iron	77-81	homeostatic iron regulator	Homo sapiens	139-142
10984552-1	2000	The recent discovery of HFE, the MHC-Class-I-like gene mutated in up to 90% of patients with hereditary haemochromatosis, and the gene encoding the Nramp2/divalent metal transporter-1 (DMT-1) implicated in ferrous iron transport holds promise for a greater understanding of human iron metabolism.	Iron	214-218	homeostatic iron regulator	Homo sapiens	24-27
10984552-1	2000	The recent discovery of HFE, the MHC-Class-I-like gene mutated in up to 90% of patients with hereditary haemochromatosis, and the gene encoding the Nramp2/divalent metal transporter-1 (DMT-1) implicated in ferrous iron transport holds promise for a greater understanding of human iron metabolism.	Iron	280-284	homeostatic iron regulator	Homo sapiens	24-27
10984552-2	2000	Since the HFE protein can be crystallized as a ternary complex with the transferrin receptor and iron-saturated transferrin, and DMT-1 expression is up-regulated in hereditary haemochromatosis, these proteins are likely to interact in a common pathway for human iron homeostasis.	Iron	97-101	homeostatic iron regulator	Homo sapiens	10-13
10984552-2	2000	Since the HFE protein can be crystallized as a ternary complex with the transferrin receptor and iron-saturated transferrin, and DMT-1 expression is up-regulated in hereditary haemochromatosis, these proteins are likely to interact in a common pathway for human iron homeostasis.	Iron	262-266	homeostatic iron regulator	Homo sapiens	10-13
10984552-6	2000	In the human cell lines, Caco-2 (small intestinal phenotype upon differentiation) and K562 (erythroleukaemic) HFE, in the presence of iron-saturated transferrin, co-localized with transferrin receptors in an early endosome compartment using confocal immunofluorescence microscopy.	Iron	134-138	homeostatic iron regulator	Homo sapiens	110-113
10984552-7	2000	This interaction may be critical in small-intestinal crypt cells which express HFE, where it may function to modulate their intrinsic iron status thereby programming iron absorption by DMT-1 in the mature enterocyte.	Iron	134-138	homeostatic iron regulator	Homo sapiens	79-82
10984552-7	2000	This interaction may be critical in small-intestinal crypt cells which express HFE, where it may function to modulate their intrinsic iron status thereby programming iron absorption by DMT-1 in the mature enterocyte.	Iron	166-170	homeostatic iron regulator	Homo sapiens	79-82
10984552-9	2000	Disruption of the HFE gene as a result of mutations associated with hereditary haemochromatosis may thus impair homeostatic mechanisms controlling iron absorption within the small-intestine epithelium by a direct interaction with transferrin receptors and by subsequent alteration of DMT-1 expression.	Iron	147-151	homeostatic iron regulator	Homo sapiens	18-21
10984552-10	2000	Identification of the molecular interactions of HFE with DMT-1 and other key components of the iron transport pathway has implications for a mechanistic understanding of the pathophysiology of human iron storage diseases as well as the regulation of normal iron balance.	Iron	95-99	homeostatic iron regulator	Homo sapiens	48-51
10984552-10	2000	Identification of the molecular interactions of HFE with DMT-1 and other key components of the iron transport pathway has implications for a mechanistic understanding of the pathophysiology of human iron storage diseases as well as the regulation of normal iron balance.	Iron	199-203	homeostatic iron regulator	Homo sapiens	48-51
10984552-10	2000	Identification of the molecular interactions of HFE with DMT-1 and other key components of the iron transport pathway has implications for a mechanistic understanding of the pathophysiology of human iron storage diseases as well as the regulation of normal iron balance.	Iron	199-203	homeostatic iron regulator	Homo sapiens	48-51
10934140-0	2000	Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.	Iron	29-33	synuclein gamma	Homo sapiens	94-109
11039663-10	2000	These observations suggest that the mode of iron accumulation caused by the lack of ALAS-E is different in primitive and definitive erythroid cells.	Iron	44-48	5'-aminolevulinate synthase 2	Homo sapiens	84-90
11039663-11	2000	Thus ALAS-E, and hence heme supply, is necessary for erythroid cell differentiation and iron metabolism.	Iron	88-92	5'-aminolevulinate synthase 2	Homo sapiens	5-11
10956153-8	2000	Bean genotypes with higher seed Fe concentrations resulted in increased amounts of bioavailable Fe to rats.	Iron	32-34	brain expressed, associated with NEDD4, 1	Rattus norvegicus	0-4
10956153-8	2000	Bean genotypes with higher seed Fe concentrations resulted in increased amounts of bioavailable Fe to rats.	Iron	96-98	brain expressed, associated with NEDD4, 1	Rattus norvegicus	0-4
10956153-10	2000	Other unknown seed factors (i.e., antinutrients or promoter substances) may be contributing factors affecting Fe bioavailability from bean seeds.	Iron	110-112	brain expressed, associated with NEDD4, 1	Rattus norvegicus	134-138
10968616-6	2000	A potential utility of 19F NMR, combined with the use of a symmetric fluorinated hemin, in characterizing the heme electronic structure of myoglobin in a variety of iron oxidation, spin, and ligation states, is presented.	Iron	165-169	myoglobin	Physeter catodon	139-148
10891064-1	2000	Iron-sulfur cluster biosynthesis in both prokaryotic and eukaryotic cells is known to be mediated by two highly conserved proteins, termed IscS and IscU in prokaryotes.	Iron	0-4	NFS1 cysteine desulfurase	Homo sapiens	139-143
10891064-3	2000	In this work, the time course of IscS-mediated Fe-S cluster assembly in IscU was monitored via anaerobic anion exchange chromatography.	Iron	47-51	NFS1 cysteine desulfurase	Homo sapiens	33-37
11001096-15	2000	Since a shorter distance from Gln to Fe and stronger interaction with Fe correlate with a lower Em in Fe(Mn)SOD, Gln has the effect of destabilizing additional electron density on the metal ion.	Iron	37-39	superoxide dismutase 2	Homo sapiens	108-111
11001096-15	2000	Since a shorter distance from Gln to Fe and stronger interaction with Fe correlate with a lower Em in Fe(Mn)SOD, Gln has the effect of destabilizing additional electron density on the metal ion.	Iron	70-72	superoxide dismutase 2	Homo sapiens	108-111
10886564-14	2000	Disturbing cholesterol/microdomains with a sublytic CE dose dramatically increased tubule susceptibility to Fe-mediated oxidative stress and Ca2+ overload, but not PLA2-mediated damage.	Iron	108-110	carboxyl ester lipase	Mus musculus	52-54
10837493-0	2000	MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis.	Iron	71-75	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-6
10837493-1	2000	Atm1p, a mitochondrial half-type ATP-binding cassette (ABC) protein in Saccharomyces cerevisiae, transports a precursor of the iron-sulfur (Fe/S) cluster from mitochondria to the cytosol.	Iron	127-131	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	0-5
10837493-1	2000	Atm1p, a mitochondrial half-type ATP-binding cassette (ABC) protein in Saccharomyces cerevisiae, transports a precursor of the iron-sulfur (Fe/S) cluster from mitochondria to the cytosol.	Iron	140-142	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	0-5
10837493-5	2000	Accumulation of iron in the mitochondria, mitochondrial DNA damage, and respiratory dysfunction in the yeast ATM1 mutant strain (atm1-1 mutant cells) were almost fully reversed by expressing MTABC3 in these mutant cells.	Iron	16-20	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	109-113
10837493-5	2000	Accumulation of iron in the mitochondria, mitochondrial DNA damage, and respiratory dysfunction in the yeast ATM1 mutant strain (atm1-1 mutant cells) were almost fully reversed by expressing MTABC3 in these mutant cells.	Iron	16-20	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	129-133
10837493-5	2000	Accumulation of iron in the mitochondria, mitochondrial DNA damage, and respiratory dysfunction in the yeast ATM1 mutant strain (atm1-1 mutant cells) were almost fully reversed by expressing MTABC3 in these mutant cells.	Iron	16-20	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	191-197
10837493-7	2000	Interestingly, the human MTABC3 gene has been mapped to chromosome 2q36, a region within the candidate locus for lethal neonatal metabolic syndrome, a disorder of the mitochondrial function associated with iron metabolism, indicating that MTABC3 is a candidate gene for this disorder.	Iron	206-210	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	25-31
10837493-7	2000	Interestingly, the human MTABC3 gene has been mapped to chromosome 2q36, a region within the candidate locus for lethal neonatal metabolic syndrome, a disorder of the mitochondrial function associated with iron metabolism, indicating that MTABC3 is a candidate gene for this disorder.	Iron	206-210	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	239-245
10816424-6	2000	These findings suggest that the severe decrease in IRP1 RNA-binding activity depends on: (i) linking of OMA to the active site of aconitase, which prevents the switch to IRP1 and explains resistance to the reducing agents, and (ii) possible interaction of OMA with some functional amino acid residues in IRP that are responsible for binding to the specific mRNA sequences involved in the regulation of iron metabolism.	Iron	402-406	wingless-type MMTV integration site family, member 2	Mus musculus	51-54
10875438-2	2000	IRPs regulate expression of ferritin and transferrin receptor at the mRNA level by interacting with a conserved RNA structure termed the iron-responsive element (IRE).	Iron	137-141	transferrin receptor	Homo sapiens	41-61
1457606-7	1992	Although 32 micrograms/ml ferritin, reflecting only a 3-6 fold increase in iron concentration over normal serum, was not toxic, it reduced the survival of X-irradiated cells by an additional 75%.	Iron	75-79	ferritin, mitochondrial	Cricetulus griseus	26-34
10875438-7	2000	We hypothesized that alterations in the IRP/IRE interaction could be the site at which iron mismanagement occurs in the Alzheimer"s brains.	Iron	87-91	Wnt family member 2	Homo sapiens	40-43
1327750-2	1992	Immunological assays indicate a gross reduction in the Rieske iron-sulfur subunit in bcs1 mutants, while other subunits of the ubiquinol-cytochrome c reductase complex are present at concentrations comparable to the wild type.	Iron	62-66	bifunctional AAA family ATPase chaperone/translocase BCS1	Saccharomyces cerevisiae S288C	85-89
10940080-2	2000	Functional as well as molecular studies of the HFE protein have indicated that the molecule is involved in iron metabolism and that the HFE gene variations observed among HH patients affect its interaction with the transferrin receptor (TfR).	Iron	107-111	homeostatic iron regulator	Homo sapiens	47-50
1327750-3	1992	Transformation of bcs1 mutants with the iron-sulfur protein gene on a multicopy plasmid led to elevated mitochondrial concentrations of Rieske protein, but did not correct the enzymatic defect, indicating that BCS1 is involved either in forming the active site iron-sulfur cluster or providing a chaperone-like function in assembling the Rieske protein with the other subunits of the complex.	Iron	40-44	bifunctional AAA family ATPase chaperone/translocase BCS1	Saccharomyces cerevisiae S288C	18-22
1327750-3	1992	Transformation of bcs1 mutants with the iron-sulfur protein gene on a multicopy plasmid led to elevated mitochondrial concentrations of Rieske protein, but did not correct the enzymatic defect, indicating that BCS1 is involved either in forming the active site iron-sulfur cluster or providing a chaperone-like function in assembling the Rieske protein with the other subunits of the complex.	Iron	40-44	bifunctional AAA family ATPase chaperone/translocase BCS1	Saccharomyces cerevisiae S288C	210-214
1327750-3	1992	Transformation of bcs1 mutants with the iron-sulfur protein gene on a multicopy plasmid led to elevated mitochondrial concentrations of Rieske protein, but did not correct the enzymatic defect, indicating that BCS1 is involved either in forming the active site iron-sulfur cluster or providing a chaperone-like function in assembling the Rieske protein with the other subunits of the complex.	Iron	261-265	bifunctional AAA family ATPase chaperone/translocase BCS1	Saccharomyces cerevisiae S288C	210-214
1524435-1	1992	Ceruloplasmin catalyzed the incorporation of iron into apoferritin with a stoichiometry of 3.8 Fe(II)/O2.	Iron	45-49	ceruloplasmin	Rattus norvegicus	0-13
10940080-3	2000	In the present study, we have therefore analysed the relationship between the HFE gene variants, C282Y and H63D, and body iron status among 85 German HH patients.	Iron	122-126	homeostatic iron regulator	Homo sapiens	78-81
10940080-11	2000	These data indicate that the iron intake is higher among C282Y homozygous patients compared with C282Y heterozygous or C282Y/H63D compound heterozygous individuals and supports the functional role of the HFE protein in iron metabolism whereas the TfR gene variants seem to have no influence on iron uptake.	Iron	29-33	homeostatic iron regulator	Homo sapiens	204-207
10940080-11	2000	These data indicate that the iron intake is higher among C282Y homozygous patients compared with C282Y heterozygous or C282Y/H63D compound heterozygous individuals and supports the functional role of the HFE protein in iron metabolism whereas the TfR gene variants seem to have no influence on iron uptake.	Iron	29-33	transferrin receptor	Homo sapiens	247-250
1421965-0	1992	An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein.	Iron	3-7	aconitase 1	Homo sapiens	60-99
10940080-11	2000	These data indicate that the iron intake is higher among C282Y homozygous patients compared with C282Y heterozygous or C282Y/H63D compound heterozygous individuals and supports the functional role of the HFE protein in iron metabolism whereas the TfR gene variants seem to have no influence on iron uptake.	Iron	219-223	homeostatic iron regulator	Homo sapiens	204-207
1421965-1	1992	Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element binding protein (IRE-BP), to RNA stem-loop motifs known as iron-responsive elements (IREs).	Iron	54-58	transferrin receptor	Homo sapiens	88-108
1421965-1	1992	Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element binding protein (IRE-BP), to RNA stem-loop motifs known as iron-responsive elements (IREs).	Iron	54-58	transferrin receptor	Homo sapiens	110-113
1421965-1	1992	Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element binding protein (IRE-BP), to RNA stem-loop motifs known as iron-responsive elements (IREs).	Iron	54-58	aconitase 1	Homo sapiens	182-221
1421965-1	1992	Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element binding protein (IRE-BP), to RNA stem-loop motifs known as iron-responsive elements (IREs).	Iron	54-58	aconitase 1	Homo sapiens	223-229
1421965-1	1992	Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element binding protein (IRE-BP), to RNA stem-loop motifs known as iron-responsive elements (IREs).	Iron	182-186	transferrin receptor	Homo sapiens	88-108
1421965-1	1992	Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element binding protein (IRE-BP), to RNA stem-loop motifs known as iron-responsive elements (IREs).	Iron	182-186	transferrin receptor	Homo sapiens	110-113
1421965-1	1992	Post-transcriptional regulation of genes important in iron metabolism, ferritin and the transferrin receptor (TfR), is achieved through regulated binding of a cytosolic protein, the iron-responsive element binding protein (IRE-BP), to RNA stem-loop motifs known as iron-responsive elements (IREs).	Iron	182-186	aconitase 1	Homo sapiens	223-229
1421965-3	1992	The IRE-BP senses iron levels and accordingly modifies binding to IREs through a novel sensing mechanism.	Iron	18-22	aconitase 1	Homo sapiens	4-10
10940080-11	2000	These data indicate that the iron intake is higher among C282Y homozygous patients compared with C282Y heterozygous or C282Y/H63D compound heterozygous individuals and supports the functional role of the HFE protein in iron metabolism whereas the TfR gene variants seem to have no influence on iron uptake.	Iron	219-223	homeostatic iron regulator	Homo sapiens	204-207
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	3-7	aconitase 1	Homo sapiens	30-36
10895137-1	2000	OBJECTIVE: To detect two novel mutations (C282Y and H63D) of the HFE gene in Chinese patients with hepatic iron overload.	Iron	107-111	homeostatic iron regulator	Homo sapiens	65-68
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	3-7	aconitase 1	Homo sapiens	146-152
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	54-58	aconitase 1	Homo sapiens	30-36
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	54-58	aconitase 1	Homo sapiens	146-152
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	54-58	aconitase 1	Homo sapiens	30-36
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	54-58	aconitase 1	Homo sapiens	146-152
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	54-58	aconitase 1	Homo sapiens	30-36
1421965-4	1992	An iron-sulfur cluster of the IRE-BP reversibly binds iron; when cytosolic iron levels are depleted, the cluster becomes depleted of iron and the IRE-BP acquires the capacity to bind IREs.	Iron	54-58	aconitase 1	Homo sapiens	146-152
1421965-5	1992	When cytosolic iron levels are replete, the IRE-BP loses RNA binding capacity, but acquires enzymatic activity as a functional aconitase.	Iron	15-19	aconitase 1	Homo sapiens	44-50
1421965-6	1992	RNA binding and aconitase activity are mutually exclusive activities of the IRE-BP, and the state of the iron-sulfur cluster determines how the IRE-BP will function.	Iron	105-109	aconitase 1	Homo sapiens	76-82
10923364-2	2000	HFE modulates the iron uptake by the transferrin receptor.	Iron	18-22	homeostatic iron regulator	Homo sapiens	0-3
1421965-6	1992	RNA binding and aconitase activity are mutually exclusive activities of the IRE-BP, and the state of the iron-sulfur cluster determines how the IRE-BP will function.	Iron	105-109	aconitase 1	Homo sapiens	144-150
10923364-2	2000	HFE modulates the iron uptake by the transferrin receptor.	Iron	18-22	transferrin receptor	Homo sapiens	37-57
1325905-0	1992	Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome-c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron-sulfur subunit.	Iron	151-155	cytochrome b	Saccharomyces cerevisiae S288C	18-30
10748136-11	2000	Our findings suggest a function for Isa1p in the binding of iron or an intermediate of Fe/S cluster assembly.	Iron	60-64	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	36-41
1325905-9	1992	SDS/PAGE of the purified enzyme revealed that the substitution N256Y in cytochrome b led to a loss of the iron-sulfur protein and the fifth small subunit with no change in the pattern of the remaining eight subunits.	Iron	106-110	cytochrome b	Saccharomyces cerevisiae S288C	72-84
1325905-12	1992	This is a new approach to obtain structural information about the interaction of cytochrome b with the iron-sulfur subunit.	Iron	103-107	cytochrome b	Saccharomyces cerevisiae S288C	81-93
1535218-1	1992	The reductant dependence of iron mobilization from isolated rabbit reticulocyte endosomes containing diferric transferrin is reported.	Iron	28-32	serotransferrin	Oryctolagus cuniculus	110-121
10872742-3	2000	Normal mice and a mouse model of hereditary haemochromatosis, the beta2-microglobulin (beta2m) knock out [beta2m (-/-)] mouse, which has high levels of circulating iron due to increased iron absorption, were examined.	Iron	164-168	beta-2 microglobulin	Mus musculus	87-93
10872742-3	2000	Normal mice and a mouse model of hereditary haemochromatosis, the beta2-microglobulin (beta2m) knock out [beta2m (-/-)] mouse, which has high levels of circulating iron due to increased iron absorption, were examined.	Iron	186-190	beta-2 microglobulin	Mus musculus	87-93
1315769-0	1992	Infrared evidence of azide binding to iron, copper, and non-metal sites in heart cytochrome c oxidase.	Iron	38-42	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	81-101
10952228-8	2000	Our study confirms the reliability of soluble transferrin receptor for the assessment of iron status.	Iron	89-93	transferrin receptor	Homo sapiens	46-66
1591271-0	1992	Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro.	Iron	64-68	serotransferrin	Oryctolagus cuniculus	25-36
1591271-0	1992	Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro.	Iron	64-68	serotransferrin	Oryctolagus cuniculus	46-57
1537518-5	1992	This response of the TfR gene is presumably secondary to decreased cellular iron content due to its accelerated transfer into the bloodstream, as also indicated by the low levels of ferritin subunit mRNAs found in the same tissue samples, and is not linked to faster growth rate of mucosal cells because no changes in duodenal expression of histone, a growth-related gene, were detected.	Iron	76-80	transferrin receptor	Homo sapiens	21-24
10764716-1	2000	BACKGROUND: In the UK approximately 1 in 140 people are homozygous for the C282Y mutation of the HFE gene and are at risk from iron overload caused by genetic haemochromatosis (GH).	Iron	127-131	homeostatic iron regulator	Homo sapiens	97-100
1537518-6	1992	In patients with secondary iron overload, a down-regulation of duodenal TfR gene expression and a concomitant increase in ferritin mRNA content were documented.	Iron	27-31	transferrin receptor	Homo sapiens	72-75
10845668-14	2000	Because of the small size of the series, HFE C282Y mutation should be investigated on a larger scale in patients with HCC in NCL with iron overload in order to confirm this association.	Iron	134-138	homeostatic iron regulator	Homo sapiens	41-44
1608302-4	1992	Addition of reduced glutathione partially protected and N,N"-diphenyl-p-phenylenediamine and butylated hydroxytoluene completely protected microsomes against inactivation of ALDH, G6Pase and Cyt-P450, as well as lipid peroxidation induced by iron and ascorbate.	Iron	242-246	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	174-178
1608302-5	1992	ALDH was more susceptible than G6Pase to inactivation by iron and ascorbate, and was thus an excellent marker for oxidative stress.	Iron	57-61	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	0-4
10864004-2	2000	One hypothesis suggests that an interaction between the transferrin receptor (TfR) and the haemochromatosis protein (HFE) regulates the level of iron loading in crypt cells.	Iron	145-149	transferrin receptor	Rattus norvegicus	56-76
1959858-7	1991	In fact, a lower signal for transferrin receptor messenger RNA was consistently detected in iron-overloaded patients vs. control subjects, particularly in patients with thalassemia major and idiopathic hemochromatosis (p less than 0.001).	Iron	92-96	transferrin receptor	Homo sapiens	28-48
1959868-1	1991	UNLABELLED: Hexachlorobenzene-induced porphyria is iron dependent and characterized by the decreased activity of uroporphyrinogen decarboxylase and the accumulation of porphyrins in the liver.	Iron	51-55	uroporphyrinogen decarboxylase	Mus musculus	113-143
10864004-2	2000	One hypothesis suggests that an interaction between the transferrin receptor (TfR) and the haemochromatosis protein (HFE) regulates the level of iron loading in crypt cells.	Iron	145-149	transferrin receptor	Rattus norvegicus	78-81
10864004-2	2000	One hypothesis suggests that an interaction between the transferrin receptor (TfR) and the haemochromatosis protein (HFE) regulates the level of iron loading in crypt cells.	Iron	145-149	homeostatic iron regulator	Rattus norvegicus	117-120
1915737-2	1991	Recent studies suggest that the transferrin receptor mediates the intracellular delivery and transport of iron bound to transferrin in the CNS.	Iron	106-110	transferrin receptor	Mus musculus	32-52
1915737-4	1991	Our hypothesis is that abnormal iron handling by the transferrin receptor may contribute to the formation of free radical species which catalyze the lipid peroxidation of nigral cell membranes.	Iron	32-36	transferrin receptor	Mus musculus	53-73
10864004-4	2000	Mice with haploinsufficiency for TfR are iron deficient and this is thought to be caused by reduced iron absorption.	Iron	41-45	transferrin receptor	Mus musculus	33-36
10864004-4	2000	Mice with haploinsufficiency for TfR are iron deficient and this is thought to be caused by reduced iron absorption.	Iron	100-104	transferrin receptor	Mus musculus	33-36
10864004-5	2000	This suggests that TfR may play a role in the regulation and/or mechanism of iron absorption.	Iron	77-81	transferrin receptor	Rattus norvegicus	19-22
10864004-6	2000	We investigated TfR function and distribution by measuring iron uptake from plasma transferrin and by immunohistochemistry.	Iron	59-63	transferrin receptor	Rattus norvegicus	16-19
1655825-7	1991	Incubation of pseudomonas elastase with transferrin which had been selectively iron loaded at either the NH2- or COOH-terminal binding site yielded iron chelates with similar efficacy for hydroxyl radical catalysis.	Iron	79-83	elastase, neutrophil expressed	Homo sapiens	26-34
10864004-14	2000	We hypothesise that TfR in the supranuclear region of villus enterocytes may play a role in iron absorption.	Iron	92-96	transferrin receptor	Rattus norvegicus	20-23
1655825-7	1991	Incubation of pseudomonas elastase with transferrin which had been selectively iron loaded at either the NH2- or COOH-terminal binding site yielded iron chelates with similar efficacy for hydroxyl radical catalysis.	Iron	148-152	elastase, neutrophil expressed	Homo sapiens	26-34
10763957-1	2000	The aims of the present study were: 1) to determine whether patients with CH-C have evidence of enhanced hepatic lipid peroxidation and to evaluate its relation to iron status, compared with that in patients with chronic hepatitis B (CH-B); and 2) to assess the effect of interferon (IFN) therapy on hepatic iron and lipid peroxidation.	Iron	308-312	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	74-78
1776464-5	1991	TfR staining of the islets was weaker in iron-overloaded rats than in the controls.	Iron	41-45	transferrin receptor	Rattus norvegicus	0-3
1776464-6	1991	These findings suggest that 1) iron uptake by islet cells in vivo is regulated and mediated by TfR, 2) intracytoplasmic Ft transforms into stainable iron in iron-overloaded rats, and 3) predominance of TfR expression in B cells may result in selective deposition of iron and predispose B cells to damage and diabetes mellitus in iron-overloaded rats.	Iron	31-35	transferrin receptor	Rattus norvegicus	95-98
10763957-4	2000	RESULTS: Hepatocytic HNE-protein adducts and iron deposits were more abundant in the patients with CH-C than in those with CH-B.	Iron	45-49	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	99-103
10763957-7	2000	CONCLUSIONS: Patients with CH-C have evidence of enhanced hepatic iron accumulation and lipid peroxidation compared to those with CH-B.	Iron	66-70	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	27-31
10763957-9	2000	These results suggest that hepatic lipid peroxidation and iron may potentially play contributory roles in the pathogenesis of CH-C.	Iron	58-62	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	126-130
10870847-0	2000	Relation between HFE mutations and mild iron-overload expression.	Iron	40-44	homeostatic iron regulator	Homo sapiens	17-20
1793565-0	1991	Correlation between levels of ferritin and the iron-containing component of ribonucleotide reductase in hydroxyurea-sensitive, -resistant, and -revertant cell lines.	Iron	47-51	ferritin, mitochondrial	Cricetulus griseus	30-38
16668395-0	1991	Plastid import and iron-sulfur cluster assembly of photosynthetic and nonphotosynthetic ferredoxin isoproteins in maize.	Iron	19-23	ferredoxin	Zea mays	88-98
10870847-2	2000	However, discrepancies in the correlation between HFE genotypes and iron-loading status have arisen.	Iron	68-72	homeostatic iron regulator	Homo sapiens	50-53
10716984-5	2000	Previous work has identified an RNR protein in yeast, Rnr4p, which is homologous to other R2 proteins but lacks a number of conserved amino acid residues involved in iron binding.	Iron	166-170	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	54-59
1909029-1	1991	Turnover of the full-length human transferrin receptor (TfR) mRNA is regulated by iron, and this regulation is mediated by the transcript"s 3" untranslated region.	Iron	82-86	transferrin receptor	Homo sapiens	34-54
1909029-1	1991	Turnover of the full-length human transferrin receptor (TfR) mRNA is regulated by iron, and this regulation is mediated by the transcript"s 3" untranslated region.	Iron	82-86	transferrin receptor	Homo sapiens	56-59
1909029-2	1991	Alterations in the sequence of the TfR mRNA regulatory region have been identified that render the mRNA unregulated by iron and intrinsically unstable.	Iron	119-123	transferrin receptor	Homo sapiens	35-38
10713272-2	2000	Iron-treated cells showed a 50% decrease in apolipoprotein B100 (Apo B100) and a 2- and 3-fold increase in semaphorin cd100 and aldose reductase mRNA, respectively, with parallel variations in Apo B100 and aldose reductase proteins.	Iron	0-4	semaphorin 4D	Homo sapiens	118-123
1651936-0	1991	Assembly of the iron-sulfur protein into the cytochrome b-c1, complex of yeast mitochondria.	Iron	16-20	cytochrome b	Saccharomyces cerevisiae S288C	45-57
10681454-4	2000	Recently a human cDNA highly homologous to TfR was identified and reported to encode a protein (TfR2) that binds holotransferrin and mediates uptake of transferrin-bound iron.	Iron	170-174	transferrin receptor	Homo sapiens	43-46
1856222-1	1991	The intracellular iron level exerts a negative feedback on transferrin receptor (TfR) expression in cells requiring iron for their proliferation, in contrast to the positive feedback observed in monocytes-macrophages.	Iron	18-22	transferrin receptor	Homo sapiens	59-79
1856222-1	1991	The intracellular iron level exerts a negative feedback on transferrin receptor (TfR) expression in cells requiring iron for their proliferation, in contrast to the positive feedback observed in monocytes-macrophages.	Iron	18-22	transferrin receptor	Homo sapiens	81-84
10681454-12	2000	From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.	Iron	82-86	transferrin receptor	Mus musculus	41-44
1856222-1	1991	The intracellular iron level exerts a negative feedback on transferrin receptor (TfR) expression in cells requiring iron for their proliferation, in contrast to the positive feedback observed in monocytes-macrophages.	Iron	116-120	transferrin receptor	Homo sapiens	59-79
1856222-1	1991	The intracellular iron level exerts a negative feedback on transferrin receptor (TfR) expression in cells requiring iron for their proliferation, in contrast to the positive feedback observed in monocytes-macrophages.	Iron	116-120	transferrin receptor	Homo sapiens	81-84
10681454-12	2000	From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.	Iron	144-148	transferrin receptor	Mus musculus	41-44
1856222-2	1991	It has been suggested recently that modulation of TfR and ferritin synthesis by iron is mediated through a cytoplasmic protein(s) (iron regulatory element-binding protein(s) (IRE-BP)), which interacts with ferritin and TfR mRNA at the level of hairpin structures (IRE), thus leading to inhibition of transferrin mRNA degradation and repression of ferritin mRNA translation.	Iron	80-84	transferrin receptor	Homo sapiens	50-53
10681454-12	2000	From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.	Iron	144-148	transferrin receptor	Mus musculus	41-44
1856222-2	1991	It has been suggested recently that modulation of TfR and ferritin synthesis by iron is mediated through a cytoplasmic protein(s) (iron regulatory element-binding protein(s) (IRE-BP)), which interacts with ferritin and TfR mRNA at the level of hairpin structures (IRE), thus leading to inhibition of transferrin mRNA degradation and repression of ferritin mRNA translation.	Iron	80-84	aconitase 1	Homo sapiens	131-173
1856222-2	1991	It has been suggested recently that modulation of TfR and ferritin synthesis by iron is mediated through a cytoplasmic protein(s) (iron regulatory element-binding protein(s) (IRE-BP)), which interacts with ferritin and TfR mRNA at the level of hairpin structures (IRE), thus leading to inhibition of transferrin mRNA degradation and repression of ferritin mRNA translation.	Iron	80-84	aconitase 1	Homo sapiens	175-182
10655175-0	2000	Does Turbulence in the Iron Convection Zone Cause the Massive Outbursts of eta Carinae?	Iron	23-27	endothelin receptor type A	Homo sapiens	75-78
1856222-2	1991	It has been suggested recently that modulation of TfR and ferritin synthesis by iron is mediated through a cytoplasmic protein(s) (iron regulatory element-binding protein(s) (IRE-BP)), which interacts with ferritin and TfR mRNA at the level of hairpin structures (IRE), thus leading to inhibition of transferrin mRNA degradation and repression of ferritin mRNA translation.	Iron	80-84	transferrin receptor	Homo sapiens	219-222
1856222-9	1991	Both the rise of TfR and spontaneous IRE-BP activity are completely inhibited in iron-supplemented T cell cultures.	Iron	81-85	transferrin receptor	Homo sapiens	17-20
1856222-9	1991	Both the rise of TfR and spontaneous IRE-BP activity are completely inhibited in iron-supplemented T cell cultures.	Iron	81-85	aconitase 1	Homo sapiens	37-43
1856222-11	1991	Monocytes maturing in vitro to macrophages show a sharp increase of spontaneous and, to a lesser extent, total IRE-BP; the addition of iron moderately stimulates the spontaneous IRE-BP activity but not the total one.	Iron	135-139	aconitase 1	Homo sapiens	178-184
10691878-7	2000	Homozygosity for either HFE variant allowed greater iron retention in the face of regular donation, but among heterozygotes the findings were inconclusive.	Iron	52-56	homeostatic iron regulator	Homo sapiens	24-27
1854807-0	1991	Analysis of non-heme iron in arachidonate 12-lipoxygenase of porcine leukocytes.	Iron	21-25	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	29-57
10657371-1	2000	BACKGROUND: Women who inherit heterozygosity for the C282Y mutation of the HFE gene may have increased serum iron indices and hemoglobin and are less likely to develop iron deficiency compared with women with the wild-type genotype.	Iron	109-113	homeostatic iron regulator	Homo sapiens	75-78
1647460-2	1991	Only haemin or the haem-containing proteins, bovine haemoglobin, human haemoglobin and bovine catalase, but not equine cytochrome C111, were capable of serving as the sole exogenous iron source.	Iron	182-186	catalase	Bos taurus	94-102
10657371-8	2000	CONCLUSIONS: Women with the compound heterozygous HFE genotype C282Y/H63D, but not the C282Y wild-type genotype, had increased values for serum iron and transferrin saturation, and the younger age group also had increased hemoglobin values.	Iron	144-148	homeostatic iron regulator	Homo sapiens	50-53
2056516-1	1991	Human lactoferrin (HLf) is an iron-binding protein and a host-defence component at the mucosal surface.	Iron	30-34	HLF transcription factor, PAR bZIP family member	Bos taurus	19-22
10692680-5	2000	Serum iron levels and transferrin saturation (but not ferritin levels or liver iron content) were significantly higher in carriers than in non-carriers of HFE mutations.	Iron	6-10	homeostatic iron regulator	Homo sapiens	155-158
2040284-9	1991	However, analysis of the fluorescence behaviour of different ligand derivatives of myoglobin in the whole pH range studied enables one to conclude that the exact protein conformation depends not only on the spin state of the Fe atom but, to a greater extent, probably on the chemical nature of the ligand and its interaction with the protein groups in the heme cavity.	Iron	225-227	myoglobin	Physeter catodon	83-92
2040285-1	1991	3. pH-dependent changes in porphyrin and tryptophan fluorescence of the complex of sperm whale apomyoglobin with protoporphyrin IX; the role of the porphyrin macrocycle and iron in formation of native myoglobin structure.	Iron	173-177	myoglobin	Physeter catodon	98-107
10692680-8	2000	Patients with chronic HCV infection carrying HFE mutations tend to present more evident body iron accumulation and a higher degree of necroinflammatory activity and fibrosis in the liver.	Iron	93-97	homeostatic iron regulator	Homo sapiens	45-48
11012093-3	2000	The present study demonstrates a novel link between alterations in TGF-beta1 regulation during malignant conversion, and the expression of ferritin, an important activity involved in a number of biological functions including iron homeostasis and cell-growth control.	Iron	226-230	transforming growth factor, beta 1	Mus musculus	67-76
2016326-9	1991	This study demonstrates that the complex role of TNF and IL-1 in iron homeostasis includes modulation of the transferrin receptor.	Iron	65-69	transferrin receptor	Homo sapiens	109-129
1652585-0	1991	Mechanisms of generation of oxygen radicals and reductive mobilization of ferritin iron by lipoamide dehydrogenase.	Iron	83-87	dihydrolipoamide dehydrogenase	Homo sapiens	91-114
15693280-8	2000	We asserted that IRP activity closely correlates with apical iron uptake and transepithelial iron transport.	Iron	61-65	Wnt family member 2	Homo sapiens	17-20
1652585-8	1991	Addition of ferritin to the NADH-lipoamide dehydrogenase system resulted in a decrease of the DMPO-OOH signal, indicating that the superoxide radical interacted with ferritin iron.	Iron	175-179	dihydrolipoamide dehydrogenase	Homo sapiens	33-56
1847276-3	1991	Iron can be taken up by the liver in several forms and by several pathways including: (1) receptor-mediated endocytosis of diferric or monoferric transferrin or ferritin, (2) reduction and carrier-facilitated internalization of iron from transferrin without internalization of the protein moiety of transferrin, (3) electrogenic uptake of low molecular weight, non-protein bound forms of iron, and (4) uptake of heme from heme-albumin, heme-hemopexin, or hemoglobin-haptoglobin complexes.	Iron	0-4	hemopexin	Homo sapiens	441-450
15693280-8	2000	We asserted that IRP activity closely correlates with apical iron uptake and transepithelial iron transport.	Iron	93-97	Wnt family member 2	Homo sapiens	17-20
15693280-10	2000	These results show that iron absorption is primarily regulated by the size of the labile iron pool, which in turn is regulated by the IRE/IRP system.	Iron	24-28	Wnt family member 2	Homo sapiens	138-141
15693280-10	2000	These results show that iron absorption is primarily regulated by the size of the labile iron pool, which in turn is regulated by the IRE/IRP system.	Iron	89-93	Wnt family member 2	Homo sapiens	138-141
2002625-10	1991	This study concludes that: 1) myoglobin modestly lowers baseline adenylate pools due to an Fe dependent mechanism; 2) myoglobin drastically accentuates shock-induced adenylate depletion by a non-hemodynamic/non-Fe dependent mechanism; 3) myoglobin nephrotoxicity cannot be attributed solely to tissue iron loading; and 4) the RAO model can completely mask important influences on ischemic cellular energetics.	Iron	91-93	myoglobin	Rattus norvegicus	30-39
10953958-1	2000	Hereditary hemochromatosis (HH) is a disorder of iron metabolism that leads to iron overload in middle age and can be caused by homozygosity for the C282Y mutation in the HFE gene.	Iron	49-53	homeostatic iron regulator	Homo sapiens	171-174
2002625-10	1991	This study concludes that: 1) myoglobin modestly lowers baseline adenylate pools due to an Fe dependent mechanism; 2) myoglobin drastically accentuates shock-induced adenylate depletion by a non-hemodynamic/non-Fe dependent mechanism; 3) myoglobin nephrotoxicity cannot be attributed solely to tissue iron loading; and 4) the RAO model can completely mask important influences on ischemic cellular energetics.	Iron	91-93	myoglobin	Rattus norvegicus	118-127
2002625-10	1991	This study concludes that: 1) myoglobin modestly lowers baseline adenylate pools due to an Fe dependent mechanism; 2) myoglobin drastically accentuates shock-induced adenylate depletion by a non-hemodynamic/non-Fe dependent mechanism; 3) myoglobin nephrotoxicity cannot be attributed solely to tissue iron loading; and 4) the RAO model can completely mask important influences on ischemic cellular energetics.	Iron	91-93	myoglobin	Rattus norvegicus	118-127
2002625-10	1991	This study concludes that: 1) myoglobin modestly lowers baseline adenylate pools due to an Fe dependent mechanism; 2) myoglobin drastically accentuates shock-induced adenylate depletion by a non-hemodynamic/non-Fe dependent mechanism; 3) myoglobin nephrotoxicity cannot be attributed solely to tissue iron loading; and 4) the RAO model can completely mask important influences on ischemic cellular energetics.	Iron	301-305	myoglobin	Rattus norvegicus	118-127
2002625-10	1991	This study concludes that: 1) myoglobin modestly lowers baseline adenylate pools due to an Fe dependent mechanism; 2) myoglobin drastically accentuates shock-induced adenylate depletion by a non-hemodynamic/non-Fe dependent mechanism; 3) myoglobin nephrotoxicity cannot be attributed solely to tissue iron loading; and 4) the RAO model can completely mask important influences on ischemic cellular energetics.	Iron	301-305	myoglobin	Rattus norvegicus	118-127
10953958-1	2000	Hereditary hemochromatosis (HH) is a disorder of iron metabolism that leads to iron overload in middle age and can be caused by homozygosity for the C282Y mutation in the HFE gene.	Iron	79-83	homeostatic iron regulator	Homo sapiens	171-174
10953958-7	2000	The low frequency of the at-risk genotype for iron overload suggests that genetic screening for HFE in Italy would not be cost effective.	Iron	46-50	homeostatic iron regulator	Homo sapiens	96-99
1645975-2	1991	Although iron plays a key role in modulating transferrin receptor expression, other physiological factors are also capable of affecting receptor expression.	Iron	9-13	transferrin receptor	Homo sapiens	45-65
10953960-9	2000	This is consistent with previous observations that indicate that primary iron overload disorders in persons of southern Italian descent and African Americans are largely attributable to non-HFE alleles.	Iron	73-77	homeostatic iron regulator	Homo sapiens	190-193
10945226-0	2000	The major histocompatibility complex-encoded HFE in iron homeostasis and immune function.	Iron	52-56	homeostatic iron regulator	Homo sapiens	45-48
2260562-1	1990	Neonatal hemochromatosis (NH), an uncommon and generally fatal disorder of infancy, is defined by hepatic disease of antenatal onset, generally manifest at birth, and by stainable iron in a tissue distribution like that seen in heritable adult-onset hemochromatosis (HH).	Iron	180-184	homeostatic iron regulator	Homo sapiens	9-24
2290804-4	1990	In the definitive placenta (day 10), TR are expressed primarily on the differentiated labyrinthine trophoblast cells involved in the maternal-fetal transfer of iron.	Iron	160-164	transferrin receptor	Mus musculus	37-39
10945226-2	2000	A functional link between HFE and iron metabolism has been established by the discovery of a physical association between HFE and the transferrin receptor.	Iron	34-38	homeostatic iron regulator	Homo sapiens	26-29
10945226-2	2000	A functional link between HFE and iron metabolism has been established by the discovery of a physical association between HFE and the transferrin receptor.	Iron	34-38	homeostatic iron regulator	Homo sapiens	122-125
10945226-2	2000	A functional link between HFE and iron metabolism has been established by the discovery of a physical association between HFE and the transferrin receptor.	Iron	34-38	transferrin receptor	Homo sapiens	134-154
10945226-4	2000	In addition, HFE appears to be an iron sensor that directly or indirectly communicates the body"s iron status to T cells, which then use cytokines as feedback modulators to achieve iron homeostasis.	Iron	34-38	homeostatic iron regulator	Homo sapiens	13-16
2168894-0	1990	Import of the iron-sulfur protein of the cytochrome b.c1 complex into yeast mitochondria.	Iron	14-18	cytochrome b	Saccharomyces cerevisiae S288C	41-53
2168894-1	1990	The yeast gene for the Rieske iron-sulfur protein of the cytochrome b.c1 complex was subcloned into the expression vector, pSP64, then transcribed and translated in vitro in a reticulocyte lysate in the presence of [35S]methionine.	Iron	30-34	cytochrome b	Saccharomyces cerevisiae S288C	57-69
10945226-4	2000	In addition, HFE appears to be an iron sensor that directly or indirectly communicates the body"s iron status to T cells, which then use cytokines as feedback modulators to achieve iron homeostasis.	Iron	98-102	homeostatic iron regulator	Homo sapiens	13-16
10945226-4	2000	In addition, HFE appears to be an iron sensor that directly or indirectly communicates the body"s iron status to T cells, which then use cytokines as feedback modulators to achieve iron homeostasis.	Iron	98-102	homeostatic iron regulator	Homo sapiens	13-16
10629190-2	2000	Holo-DtxR inhibits transcription from the iron-regulated promoters (IRPs) designated IRP1 through IRP5 as well as from the promoters for the tox and hmuO genes.	Iron	42-46	MarR family transcriptional regulator	Corynebacterium diphtheriae	5-9
2393007-4	1990	We previously described a transferrin receptor (TfR) mechanism that controls iron entry into rat mammary tissue.	Iron	77-81	transferrin receptor	Rattus norvegicus	26-46
2393007-4	1990	We previously described a transferrin receptor (TfR) mechanism that controls iron entry into rat mammary tissue.	Iron	77-81	transferrin receptor	Rattus norvegicus	48-51
2393007-5	1990	In this study lactating rats were used to determine effects of varying dietary iron during gestation and lactation on mammary TfR and MFe.	Iron	79-83	transferrin receptor	Rattus norvegicus	126-129
2393007-6	1990	Dams fed low-iron diets had a small increase in TfR, lower hematological indices (p less than 0.005), and lower MFe (p less than 0.005) than did controls or dams fed high iron.	Iron	13-17	transferrin receptor	Rattus norvegicus	48-51
2393007-7	1990	Dams fed the high-iron diet had a significant increase in TfR without a concomitant increase in MFe.	Iron	18-22	transferrin receptor	Rattus norvegicus	58-61
10626647-9	1999	The AP-1 was high in F, Ba, S, and Th; AP-2 and AP-3 were high in F and S; and AP-4 was high in F, Ba, Fe, Mg, Ti, and Th.	Iron	103-105	transcription factor AP-4	Homo sapiens	79-83
2168153-2	1990	Hepatic iron plays a key role in the expression of the metabolic lesions, i.e., defective hepatic decarboxylation of porphyrinogens, catalyzed by uroporphyrinogen decarboxylase.	Iron	8-12	uroporphyrinogen decarboxylase	Homo sapiens	146-176
2390101-0	1990	Effect of lead on the transport of transferrin-free and transferrin-bound iron into rabbit reticulocytes.	Iron	74-78	serotransferrin	Oryctolagus cuniculus	56-67
10567692-0	1999	The effect of iron limitation on glycerol production and expression of the isogenes for NAD(+)-dependent glycerol 3-phosphate dehydrogenase in Saccharomyces cerevisiae.	Iron	14-18	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	105-139
2390101-7	1990	Pb also inhibited the uptake of transferrin-bound iron but at higher concentrations (IC50, 4 microM) and the inhibition was less readily reversible.	Iron	50-54	serotransferrin	Oryctolagus cuniculus	32-43
2165054-0	1990	Transfer of iron from uteroferrin (purple acid phosphatase) to transferrin related to acid phosphatase activity.	Iron	12-16	transferrin	Sus scrofa	63-74
10567692-2	1999	This work examines the role and regulation of GPD1 and GPD2, encoding two isoforms of glycerol 3-phosphate dehydrogenase, in glycerol production during iron starvation.	Iron	152-156	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	86-120
10559391-0	1999	Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.	Iron	84-88	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	232-245
2159465-0	1990	Infrared evidence of cyanide binding to iron and copper sites in bovine heart cytochrome c oxidase.	Iron	40-44	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	78-98
10559391-7	1999	We show that mRNA, protein, and/or activity levels for genes whose expression is known to be regulated by HIF-1, including glycolytic enzymes, p21(waf1/cip1), and erythropoietin, are increased in cortical neuronal cultures in response to iron chelator treatment.	Iron	238-242	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	143-156
10556622-4	1999	Interestingly, iron also positively affects three other citric acid cycle enzymes, namely citrate synthase, isocitric dehydrogenase, and succinate dehydrogenase, while DFO decreases the activity of these enzymes.	Iron	15-19	citrate synthase	Homo sapiens	90-106
2108730-8	1990	Thus, the transferrin-reticulocyte interaction is sensitive to environmental variables, and such sensitivity may help account for apparent discrepancies in previous studies of the relative iron-donating abilities of the two sites of transferrin.	Iron	66-70	serotransferrin	Oryctolagus cuniculus	233-244
10557259-5	1999	The crystal structure of a P450(cam):Ru-adamantyl complex reveals access to the active center via a channel whose depth (Ru-Fe distance is 21 A) is virtually the same as that extracted from an analysis of the energy-transfer kinetics.	Iron	124-126	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	27-31
2336358-0	1990	Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation.	Iron	27-31	transferrin receptor	Homo sapiens	96-116
2336358-1	1990	The synthesis of both transferrin receptor (TfR) and ferritin is regulated post-transcriptionally by iron.	Iron	101-105	transferrin receptor	Homo sapiens	22-42
2336358-1	1990	The synthesis of both transferrin receptor (TfR) and ferritin is regulated post-transcriptionally by iron.	Iron	101-105	transferrin receptor	Homo sapiens	44-47
10557317-3	1999	As yet, our understanding of HFE function in iron homeostasis is only partial; an even more open question is its possible role in the immune system.	Iron	45-49	homeostatic iron regulator	Homo sapiens	29-32
2336358-2	1990	This is mediated by iron responsive elements (IREs) in the 5"- and 3"-untranslated regions, respectively, of TfR and ferritin mRNAs.	Iron	20-24	transferrin receptor	Homo sapiens	109-112
10586619-4	1999	The relationship of a second polymorphic variant of the HFE gene, H63D to the formation of iron overload is debated.	Iron	91-95	homeostatic iron regulator	Homo sapiens	56-59
2312055-0	1990	Transferrin receptor expression in rat liver: immunohistochemical and biochemical analysis of the effect of age and iron storage.	Iron	116-120	transferrin receptor	Rattus norvegicus	0-20
2310376-5	1990	Calmidazolium and other putative calmodulin antagonists exerted an identical action on iron uptake and receptor recycling.	Iron	87-91	calmodulin 1	Rattus norvegicus	33-43
10665381-1	1999	Lactoferrin is a major iron-binding protein in milk from several species, such as humans, monkeys, mice and sows.	Iron	23-27	lactotransferrin	Sus scrofa	0-11
10544286-0	1999	Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli.	Iron	109-113	hypothetical protein	Escherichia coli	63-67
1688718-6	1990	In the marrow of splenectomized and intact mice treated with a high dose of G-CSF, erythroid suppression in the marrow was confirmed with radioactive iron.	Iron	150-154	colony stimulating factor 3 (granulocyte)	Mus musculus	76-81
2386531-3	1990	Using an antibody attached to an iron core bead, we have shown that other plasma membrane activities (nucleoside transporter and acetylcholine esterase) are packaged in the same exosome as the transferrin receptor.	Iron	33-37	transferrin receptor	Homo sapiens	193-213
10544286-2	1999	In Escherichia coli, genes in the ORF1-ORF2-iscS-iscU-iscA-hscB-hsc A-fdx-ORF3 cluster (the isc gene cluster) should be involved in the assembly of the Fe-S cluster since its coexpression with the reporter ferredoxin (Fd) dramatically increases the production of holoFd [Nakamura, M., Saeki, K., and Takahashi, Y.	Iron	152-156	hypothetical protein	Escherichia coli	74-78
10592329-5	1999	The pattern is reverted under iron overload: IRP-mRNA binding affinity is reduced, which results in efficient protein synthesis of target transcripts harboring IREs in the 5"-UTR and rapid degradation of TfR mRNA.	Iron	30-34	Wnt family member 2	Homo sapiens	45-48
2400627-3	1990	(2) Total iron absorption is significantly higher in ceruloplasmin-substituted copper-deficient animals as compared to copper-deficient controls.	Iron	10-14	ceruloplasmin	Rattus norvegicus	53-66
2400627-4	1990	(3) The appearance rate of absorbed iron in the portal blood of copper-deficient animals increased several times immediately after the intravenous infusion of ceruloplasmin.	Iron	36-40	ceruloplasmin	Rattus norvegicus	159-172
2400627-5	1990	(5) The distribution of absorbed iron was changed due to the ceruloplasmin substitution: it was increased in the reticulocytes (+66%), plasma (+400%) and the body (+112%), whereas in the liver it was decreased by about 78%.	Iron	33-37	ceruloplasmin	Rattus norvegicus	61-74
2400627-7	1990	(6) The conclusion was drawn that, as for the entrance into the mucosa from the luminal side, also for the release at the contraluminal side into the portal blood, the ferrous state of iron is favoured and that ceruloplasmin accelerates the release into the portal blood by catalyzing the oxidation of ferrous iron due to its high Fe(II): oxygen oxidoreductase (EC 1.16.3.1) activity.	Iron	310-314	ceruloplasmin	Rattus norvegicus	211-224
10592329-5	1999	The pattern is reverted under iron overload: IRP-mRNA binding affinity is reduced, which results in efficient protein synthesis of target transcripts harboring IREs in the 5"-UTR and rapid degradation of TfR mRNA.	Iron	30-34	transferrin receptor	Homo sapiens	204-207
10511692-0	1999	Iron acquisition by Plasmodium spp.	Iron	0-4	histocompatibility minor 13	Homo sapiens	31-34
2133655-1	1990	Excess iron results in an increase in the translation of ferritin mRNA and a decrease in the stability of transferrin receptor (TfR) mRNA.	Iron	7-11	transferrin receptor	Homo sapiens	106-126
2133655-1	1990	Excess iron results in an increase in the translation of ferritin mRNA and a decrease in the stability of transferrin receptor (TfR) mRNA.	Iron	7-11	transferrin receptor	Homo sapiens	128-131
10609274-1	1999	Identification of the HFE gene and its C282Y and H63D mutations has improved the classification of iron overload disorders.	Iron	99-103	homeostatic iron regulator	Homo sapiens	22-25
33942503-3	2021	We found that pro-inflammatory cytokines could disrupt chondrocytes iron homeostasis via upregulating iron influx transporter TfR1 and downregulating iron efflux transporter FPN, thus leading to chondrocytes iron overload.	Iron	68-72	transferrin receptor	Homo sapiens	126-130
33942503-3	2021	We found that pro-inflammatory cytokines could disrupt chondrocytes iron homeostasis via upregulating iron influx transporter TfR1 and downregulating iron efflux transporter FPN, thus leading to chondrocytes iron overload.	Iron	102-106	transferrin receptor	Homo sapiens	126-130
33942503-3	2021	We found that pro-inflammatory cytokines could disrupt chondrocytes iron homeostasis via upregulating iron influx transporter TfR1 and downregulating iron efflux transporter FPN, thus leading to chondrocytes iron overload.	Iron	102-106	transferrin receptor	Homo sapiens	126-130
10609274-2	1999	Inherited hemochromatosis is due mainly, or perhaps only, to C282Y homozygosity, whereas nonhemochromatosis forms of iron overload are due to other HFE mutations and are usually responsible for mild overload precipitated by another factor such as cirrhosis or insulin-resistance.	Iron	117-121	homeostatic iron regulator	Homo sapiens	148-151
33942503-3	2021	We found that pro-inflammatory cytokines could disrupt chondrocytes iron homeostasis via upregulating iron influx transporter TfR1 and downregulating iron efflux transporter FPN, thus leading to chondrocytes iron overload.	Iron	102-106	transferrin receptor	Homo sapiens	126-130
10585494-0	1999	Homology modeling of the multicopper oxidase Fet3 gives new insights in the mechanism of iron transport in yeast.	Iron	89-93	ferroxidase FET3	Saccharomyces cerevisiae S288C	45-49
10585494-1	1999	Fet3, the multicopper oxidase of yeast, oxidizes extracellular ferrous iron which is then transported into the cell through the permease Ftr1.	Iron	71-75	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-4
33799121-5	2021	Consistent with this is the activation of iron regulator protein (IRP) RNA-binding activity, which is an important regulator of iron homeostasis, with its activation indicating cytosolic iron deficiency.	Iron	42-46	Wnt family member 2	Homo sapiens	66-69
10498610-4	1999	Addition of the NO synthase (NOS) inhibitor N-monomethyl arginine (NMMA) partially restored Fe uptake but either had no effect on or downregulated TfR expression, which suggests that NO by itself is able to affect iron availability.	Iron	92-94	nitric oxide synthase 1, neuronal	Mus musculus	16-27
33232715-7	2021	In most types of cell including erythrocyte, transferrin-bound iron is incorporated through transferrin-transferrin receptor system.	Iron	63-67	transferrin receptor	Homo sapiens	104-124
10498610-4	1999	Addition of the NO synthase (NOS) inhibitor N-monomethyl arginine (NMMA) partially restored Fe uptake but either had no effect on or downregulated TfR expression, which suggests that NO by itself is able to affect iron availability.	Iron	214-218	nitric oxide synthase 1, neuronal	Mus musculus	16-27
10529482-0	1999	Iron-independent neuronal expression of transferrin receptor mRNA in the rat.	Iron	0-4	transferrin receptor	Rattus norvegicus	40-60
33803544-6	2021	Our results evidence that cells treated with the nanoformulation [TAT-PLGA(BMNPs)] show up to 80% more iron internalized (after 72 h) compared to that of cells treated with BMNPs (40%), without any significant decrease in cell viability.	Iron	103-107	tyrosine aminotransferase	Homo sapiens	66-69
33815364-1	2021	The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.	Iron	196-200	transferrin receptor	Homo sapiens	4-26
33815364-1	2021	The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.	Iron	196-200	transferrin receptor	Homo sapiens	28-32
33815364-1	2021	The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.	Iron	237-241	transferrin receptor	Homo sapiens	4-26
33815364-1	2021	The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.	Iron	237-241	transferrin receptor	Homo sapiens	28-32
10497029-1	1999	The diphtheria toxin repressor (DtxR) is the prototype of a family of iron-dependent regulator (IdeR) proteins, which are activated by divalent iron and bind DNA to prevent the transcription of downstream genes.	Iron	70-74	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
33803174-0	2021	Nitrogen Dissolution in Liquid Ga and Fe: Comprehensive Ab Initio Analysis, Relevance for Crystallization of GaN.	Iron	38-40	gigaxonin	Homo sapiens	109-112
33803174-12	2021	It indicates that liquid Fe could be a prospective solvent for GaN crystallization from metallic solutions.	Iron	25-27	gigaxonin	Homo sapiens	63-66
33236955-2	2021	We investigated whether iron availability affects TfR1 endocytic cycle and protein stability in HepG2 hepatoma cells exposed to ferric ammonium citrate (FAC).	Iron	24-28	transferrin receptor	Homo sapiens	50-54
33236955-7	2021	This unconventional endocytic regulatory mechanism aimed at reducing surface TfR1 may represent an additional post-translational control to prevent iron overload.	Iron	148-152	transferrin receptor	Homo sapiens	77-81
33236955-8	2021	Our results show that iron is a key regulator of the trafficking of TfR1, which has been widely used to study endocytosis often not considering its function in iron homeostasis.	Iron	22-26	transferrin receptor	Homo sapiens	68-72
33236955-8	2021	Our results show that iron is a key regulator of the trafficking of TfR1, which has been widely used to study endocytosis often not considering its function in iron homeostasis.	Iron	160-164	transferrin receptor	Homo sapiens	68-72
27405089-2	2016	Iron(II) supramolecular helicates were evaluated for their in vitro activity to inhibit Tat-TAR RNA interaction using UV melting studies, electrophoretic mobility shift assay, and RNase A footprinting.	Iron	0-4	ribonuclease A family member 1, pancreatic	Homo sapiens	180-187
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	167-171	transmembrane serine protease 6	Mus musculus	13-45
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	167-171	transmembrane serine protease 6	Mus musculus	47-54
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	167-171	transmembrane serine protease 6	Mus musculus	68-80
22897769-8	2012	Proteinase activity was increased by Ca(2+) and Mg(2+), and inhibited by Cu(2+), Zn(2+), Cd(2+), and Fe(2+).	Iron	101-103	endogenous retrovirus group K member 18	Homo sapiens	0-10
18990219-1	2008	BACKGROUND: Hereditary Hemochromatosis(HH) is a common genetic disorder of iron overload where the large majority of patients are homozygous for one ancestral mutation in the HFE gene.	Iron	75-79	homeostatic iron regulator	Homo sapiens	175-178
15626737-3	2005	Here we show that iron uptake mediated by the transferrin receptor (TfR) delivers a signal that leads to IFN-gammaR2 internalization and thus plays an essential role in attenuating activation of the IFN-gamma/STAT1 pathway in human T lymphocytes.	Iron	18-22	transferrin receptor	Homo sapiens	46-66
15626737-3	2005	Here we show that iron uptake mediated by the transferrin receptor (TfR) delivers a signal that leads to IFN-gammaR2 internalization and thus plays an essential role in attenuating activation of the IFN-gamma/STAT1 pathway in human T lymphocytes.	Iron	18-22	transferrin receptor	Homo sapiens	68-71
15015763-0	2003	Alpha-difluoromethylornithine, ornithine decarboxylase inhibitor, antagonizes H2O2-induced cytotoxicity in HL-60 leukemia cells: regulation of iron-dependent lysosomal damage.	Iron	143-147	ornithine decarboxylase 1	Homo sapiens	31-54
9931428-1	1998	A complementation approach of the yeast fet3fet4 mutant strain, defective in both low- and high-affinity iron transport, was initiated as an attempt to characterize the Fe(III)-mugineic acid (MA) transporter from grasses.	Iron	105-109	ferroxidase FET3	Saccharomyces cerevisiae S288C	40-48
34872779-1	2022	The iron metal-organic framework composite with chitosan (CS/MOF-235) was synthesized using a solvothermal method and its synthesis was confirmed by surface area, PZC, XRD, FESEM, XPS, TGA, TEM, EDX mapping and EDX analysis.	Iron	4-8	citrate synthase	Homo sapiens	58-60
34872779-2	2022	The chitosan composite of the iron metal-organic framework (CS/MOF-235), MOF-235 and chitosan were used for the removal of methylene blue (MB) and methyl orange (MO) from aqueous solutions.	Iron	30-40	citrate synthase	Homo sapiens	60-62
34780743-0	2022	Using Fe-Cu/HGF composite cathodes for the degradation of Diuron by electro-activated peroxydisulfate.	Iron	6-8	hepatocyte growth factor	Homo sapiens	12-15
34780743-1	2022	An iron-copper graphite felt (Fe-Cu/HGF) electrode was successfully prepared by heat treatment and impregnation of graphite felt as the support followed by calcination, and an electro-activated peroxydisulfate (E-PDS) system with Fe-Cu/HGF as the cathode was constructed to degrade Diuron.	Iron	3-7	hepatocyte growth factor	Homo sapiens	36-39
34780743-1	2022	An iron-copper graphite felt (Fe-Cu/HGF) electrode was successfully prepared by heat treatment and impregnation of graphite felt as the support followed by calcination, and an electro-activated peroxydisulfate (E-PDS) system with Fe-Cu/HGF as the cathode was constructed to degrade Diuron.	Iron	3-7	hepatocyte growth factor	Homo sapiens	236-239
34780743-4	2022	The Fe-Cu/HGF composite cathode exhibited a performance superior to graphite felt (RGF) obtained using pretreatment only, including increased hydrophilicity, significantly increased number of defect sites and larger electroactive surface area.	Iron	4-6	hepatocyte growth factor	Homo sapiens	10-13
34793849-7	2022	Moreover, MPs induced lipid peroxidation in the liver of mice could activate the expression of ferroptosis related proteins, including iron metabolism, such as transferrin receptor (TFRC) was active but ferritin heavy chain 1 (FTH1) was inhibited; amino acid metabolism, such as XCT system and glutathione peroxidase 4 (GPX4) were inhibited; lipid metabolism, such as acyl-CoA synthetase long-chain family member 4 (ACSL4) was inhibited.	Iron	135-139	transferrin receptor	Mus musculus	160-180
34793849-7	2022	Moreover, MPs induced lipid peroxidation in the liver of mice could activate the expression of ferroptosis related proteins, including iron metabolism, such as transferrin receptor (TFRC) was active but ferritin heavy chain 1 (FTH1) was inhibited; amino acid metabolism, such as XCT system and glutathione peroxidase 4 (GPX4) were inhibited; lipid metabolism, such as acyl-CoA synthetase long-chain family member 4 (ACSL4) was inhibited.	Iron	135-139	transferrin receptor	Mus musculus	182-186
34801473-1	2022	In humans, the loss of frataxin results in Friedreich"s Ataxia, a neurodegenerative disease, in which a deficit in the iron-sulfur cluster assembly is observed.	Iron	119-123	frataxin	Homo sapiens	23-31
34826546-4	2022	We found that iron, manifesting as ferric ammonium citrate (FAC; 0.05-4.8 mM), significantly inhibited cell growth, induced oxidative stress through the Fenton reaction, and functionally activated autophagy in EuESCs, as measured by 5-ethynyl-2"-deoxyuridine incorporation assay, MitoSOX  Red staining, LC3 turnover assay, and tandem mCherry-eGFP-LC3B fluorescence microscopy.	Iron	14-18	microtubule associated protein 1 light chain 3 beta	Homo sapiens	347-351
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	Iron	141-143	angiotensin II receptor type 1	Homo sapiens	116-120
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	Iron	141-143	angiotensin II receptor type 1	Homo sapiens	188-192
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	Iron	185-187	angiotensin II receptor type 1	Homo sapiens	116-120
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	Iron	185-187	angiotensin II receptor type 1	Homo sapiens	188-192
34490613-0	2022	Severe iron overload in a woman with homeostatic iron regulator (HFE) and a novel 5"-aminolevulinate synthase 2 (ALAS2) mutations: interactions of multiple genetic determinants.	Iron	7-11	homeostatic iron regulator	Homo sapiens	65-68
34490613-0	2022	Severe iron overload in a woman with homeostatic iron regulator (HFE) and a novel 5"-aminolevulinate synthase 2 (ALAS2) mutations: interactions of multiple genetic determinants.	Iron	7-11	5'-aminolevulinate synthase 2	Homo sapiens	82-111
34490613-0	2022	Severe iron overload in a woman with homeostatic iron regulator (HFE) and a novel 5"-aminolevulinate synthase 2 (ALAS2) mutations: interactions of multiple genetic determinants.	Iron	7-11	5'-aminolevulinate synthase 2	Homo sapiens	113-118
34490613-0	2022	Severe iron overload in a woman with homeostatic iron regulator (HFE) and a novel 5"-aminolevulinate synthase 2 (ALAS2) mutations: interactions of multiple genetic determinants.	Iron	49-53	homeostatic iron regulator	Homo sapiens	65-68
34807408-4	2022	The brain cortex of HtrA2Hetero mice had increased superoxide dismutase (SOD) activity; lower levels of malondialdehyde (MDA); higher expressions of mitochondrial unfolded protein response (mtUPR)-related proteins, NADH dehydrogenase (ubiquinone) iron-sulfur protein 7 (Ndufs7), and uncoupling protein 2 (UCP2) proteins; more mitochondrial fission; higher levels of ATP and mtDNA copies; elevated sirtuin 3 (SIRT3) activity; and increased NAD+/NADH ratio.	Iron	247-251	HtrA serine peptidase 2	Mus musculus	20-25
34962017-2	2022	Therefore, manipulating iron metabolisms, such as using iron chelators, transferrin receptor 1 (TFR1) antibodies, and cytotoxic ligands conjugated to transferrin, has become a considera.	Iron	24-28	transferrin receptor	Homo sapiens	72-94
34962017-2	2022	Therefore, manipulating iron metabolisms, such as using iron chelators, transferrin receptor 1 (TFR1) antibodies, and cytotoxic ligands conjugated to transferrin, has become a considera.	Iron	24-28	transferrin receptor	Homo sapiens	96-100
34930834-6	2021	The SOD function of Cygb was inhibited by cyanide and CO that coordinate to Fe3+-Cygb and Fe2+-Cygb, respectively, suggesting that dismutation involves iron redox cycling, and this was confirmed by spectrophotometric titrations.	Iron	152-156	cytoglobin	Mus musculus	20-24
34930834-6	2021	The SOD function of Cygb was inhibited by cyanide and CO that coordinate to Fe3+-Cygb and Fe2+-Cygb, respectively, suggesting that dismutation involves iron redox cycling, and this was confirmed by spectrophotometric titrations.	Iron	152-156	cytoglobin	Mus musculus	81-85
34930834-6	2021	The SOD function of Cygb was inhibited by cyanide and CO that coordinate to Fe3+-Cygb and Fe2+-Cygb, respectively, suggesting that dismutation involves iron redox cycling, and this was confirmed by spectrophotometric titrations.	Iron	152-156	cytoglobin	Mus musculus	95-99
10497029-1	1999	The diphtheria toxin repressor (DtxR) is the prototype of a family of iron-dependent regulator (IdeR) proteins, which are activated by divalent iron and bind DNA to prevent the transcription of downstream genes.	Iron	70-74	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
10497029-1	1999	The diphtheria toxin repressor (DtxR) is the prototype of a family of iron-dependent regulator (IdeR) proteins, which are activated by divalent iron and bind DNA to prevent the transcription of downstream genes.	Iron	144-148	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
10497029-1	1999	The diphtheria toxin repressor (DtxR) is the prototype of a family of iron-dependent regulator (IdeR) proteins, which are activated by divalent iron and bind DNA to prevent the transcription of downstream genes.	Iron	144-148	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
10497029-2	1999	In Corynebacterium diphtheriae, DtxR regulates not only the expression of diphtheria toxin encoded by a corynebacteriophage, but also of components of the siderophore-mediated iron-transport system.	Iron	176-180	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
10471457-1	1999	BACKGROUND AND METHODS: Hereditary hemochromatosis is associated with homozygosity for the C282Y mutation in the hemochromatosis (HFE) gene on chromosome 6, elevated serum transferrin saturation, and excess iron deposits throughout the body.	Iron	207-211	homeostatic iron regulator	Homo sapiens	35-50
10471457-1	1999	BACKGROUND AND METHODS: Hereditary hemochromatosis is associated with homozygosity for the C282Y mutation in the hemochromatosis (HFE) gene on chromosome 6, elevated serum transferrin saturation, and excess iron deposits throughout the body.	Iron	207-211	homeostatic iron regulator	Homo sapiens	130-133
10520411-9	1999	As HFE encodes a membrane protein similar to HLA class I protein, its contribution to iron overload is not obvious.	Iron	86-90	homeostatic iron regulator	Homo sapiens	3-6
10971831-10	1999	Recent investigations indicate that this cumbersome procedure can be avoided by measuring an important new iron-related measurement, the serum transferrin receptor (TfR).	Iron	107-111	transferrin receptor	Homo sapiens	143-163
10971831-10	1999	Recent investigations indicate that this cumbersome procedure can be avoided by measuring an important new iron-related measurement, the serum transferrin receptor (TfR).	Iron	107-111	transferrin receptor	Homo sapiens	165-168
10540740-9	1999	The cytochrome a, but not cytochrome b, in the most highly purified enzyme fraction was reduced by the addition of ferrous iron at pH 3.0, indicating that electrons from Fe2+ were transported to cytochrome a, but not cytochrome b.	Iron	123-127	cytochrome b	Saccharomyces cerevisiae S288C	217-229
10535463-1	1999	Mutations in the haemochromatosis (HFE) gene cause most of the cases of hereditary haemochromatosis among people of Northern European ancestry while remaining a rare cause of iron overload among indigenous persons of the Asia-Pacific region.	Iron	175-179	homeostatic iron regulator	Homo sapiens	35-38
10535463-2	1999	Advances in understanding of the role of the HFE protein product and other recently cloned iron transporters signify an exciting period, as previously unknown components of the iron metabolism pathway are revealed one by one.	Iron	91-95	homeostatic iron regulator	Homo sapiens	45-48
10519366-6	1999	Interestingly, the disease risk of 187G-genotypes suggests that subtle functional changes in the HFE product can interact with other genetic factors (e.g. trans allele, gender) and environmental factors (e.g. diet) to manifest either as clinical disease, altered iron stores or a normal phenotype.	Iron	184-188	homeostatic iron regulator	Homo sapiens	97-100
10438510-2	1999	Soluble ferredoxin (Fd) binds to PSI via electrostatic interactions and is reduced by the outermost iron-sulfur cluster of PsaC.	Iron	100-104	uncharacterized protein	Chlamydomonas reinhardtii	8-18
10495882-2	1999	The present study demonstrated that exclusive incubation with endo-alpha-N-acetylgalactosaminidase abolished the lectin Vicia villosa or Wisteria floribunda agglutinin (VVA or WFA) labeling of the nerve cell surface glycoproteins, while it neither interfered with the cationic iron colloid or aldehyde fuchsin stainings of the perineuronal proteoglycans nor abolished the Gomori"s ammoniacal silver impregnation of the collagenous ligands.	Iron	277-281	N-acetyl galactosaminidase, alpha	Mus musculus	67-98
10495882-4	1999	Triple incubations with endo-alpha-N-acetylgalactosaminidase, collagenase, and endo-alpha-N-acetylgalactosaminidase abolished the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, and also eliminated the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans and the Gomori"s ammoniacal silver impregnation of the collagenous ligands.	Iron	231-235	N-acetyl galactosaminidase, alpha	Mus musculus	29-60
10495882-4	1999	Triple incubations with endo-alpha-N-acetylgalactosaminidase, collagenase, and endo-alpha-N-acetylgalactosaminidase abolished the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, and also eliminated the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans and the Gomori"s ammoniacal silver impregnation of the collagenous ligands.	Iron	231-235	N-acetyl galactosaminidase, alpha	Mus musculus	84-115
10423453-5	1999	On the other hand, the crystal structure of the L. pectinata HbI:cyanide derivative at 100 K shows that the diatomic ligand is coordinated to the iron atom in an orientation almost perpendicular to the heme (the Fe-C distance being 1.95 A), adopting a coordination geometry strictly reminescent of that observed in sperm whale Mb, at room temperature.	Iron	146-150	myoglobin	Physeter catodon	327-329
10490241-7	1999	The ratio of SSB/8-OHdG catalyzed by chelated iron, which is twice as high as by unchelated iron, indicates that chelation affects iron-catalyzed oxidative DNA damage in a specific way favoring strand breakage over base modification.	Iron	46-50	small RNA binding exonuclease protection factor La	Homo sapiens	13-16
10490241-7	1999	The ratio of SSB/8-OHdG catalyzed by chelated iron, which is twice as high as by unchelated iron, indicates that chelation affects iron-catalyzed oxidative DNA damage in a specific way favoring strand breakage over base modification.	Iron	92-96	small RNA binding exonuclease protection factor La	Homo sapiens	13-16
10490241-7	1999	The ratio of SSB/8-OHdG catalyzed by chelated iron, which is twice as high as by unchelated iron, indicates that chelation affects iron-catalyzed oxidative DNA damage in a specific way favoring strand breakage over base modification.	Iron	92-96	small RNA binding exonuclease protection factor La	Homo sapiens	13-16
10444608-15	1999	The findings demonstrated that the increased cellular Fe uptake in exercised rats was a consequence of the increased TfR expression rather than the changes in TfR affinity and Tf recycling time.	Iron	54-56	transferrin receptor	Rattus norvegicus	117-120
10615308-15	1999	Adherence to mucin was increased threefold when parasites were grown in iron deficient medium.	Iron	72-76	LOC100508689	Homo sapiens	13-18
10383398-9	1999	The inner membrane proteins Mmt1p and Mmt2p proposed to be involved in mitochondrial iron movement are not required for the supply of ferrochelatase with iron.	Iron	85-89	Mmt1p	Saccharomyces cerevisiae S288C	28-33
34964037-0	2022	Hfe Is Highly Expressed in Liver Sinusoidal Endothelial Cells But Is Not Needed to Maintain Systemic Iron Homeostasis In Vivo.	Iron	101-105	homeostatic iron regulator	Homo sapiens	0-3
10383398-9	1999	The inner membrane proteins Mmt1p and Mmt2p proposed to be involved in mitochondrial iron movement are not required for the supply of ferrochelatase with iron.	Iron	85-89	Mmt2p	Saccharomyces cerevisiae S288C	38-43
10408393-4	1999	Addition of the iron chelator, CP94, greatly increased PpIX accumulation in human skin exposed to ALA, ALA-methyl ester and ALA-hexyl ester.	Iron	16-20	beaded filament structural protein 1	Homo sapiens	31-35
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	105-109	nuclear receptor subfamily 0 group B member 2	Homo sapiens	68-72
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	105-109	lipocalin 2	Mus musculus	132-136
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	153-157	nuclear receptor subfamily 0 group B member 2	Homo sapiens	68-72
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	153-157	lipocalin 2	Mus musculus	132-136
10383894-1	1999	A number of genes are involved in iron metabolism, including the transferrin receptor (TFR) and haemochromatosis (HFE) genes.	Iron	34-38	transferrin receptor	Homo sapiens	65-85
10383894-1	1999	A number of genes are involved in iron metabolism, including the transferrin receptor (TFR) and haemochromatosis (HFE) genes.	Iron	34-38	transferrin receptor	Homo sapiens	87-90
34873315-0	2021	Mitochondrial Clk1-iron-DAT regulation pathway: a possible new therapeutic target for methamphetamine use disorder.	Iron	19-23	CDC like kinase 1	Homo sapiens	14-18
34870866-11	2021	The data demonstrated that iron suppressed FXR expression and signaling in human and mouse hepatocytes as well as in mouse liver and intestine.	Iron	27-31	nuclear receptor subfamily 1 group H member 4	Homo sapiens	43-46
10383894-1	1999	A number of genes are involved in iron metabolism, including the transferrin receptor (TFR) and haemochromatosis (HFE) genes.	Iron	34-38	homeostatic iron regulator	Homo sapiens	114-117
10383894-3	1999	The HFE wild-type gene product complexes with the transferrin receptor (TF) and two different HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of TFR for TF and increase cellular iron uptake.	Iron	210-214	homeostatic iron regulator	Homo sapiens	4-7
10383894-3	1999	The HFE wild-type gene product complexes with the transferrin receptor (TF) and two different HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of TFR for TF and increase cellular iron uptake.	Iron	210-214	transferrin receptor	Homo sapiens	50-70
10484662-2	1999	Iron regulatory proteins (IRP1 and IRP2), two post-transcriptional regulators of gene expression, are particularly sensitive to NO synthesis and to oxidative stress.	Iron	0-4	aconitase 1	Homo sapiens	26-30
34925433-0	2021	Corrigendum: Involvement of Arabidopsis Multi-Copper Oxidase-Encoding LACCASE12 in Root-to-Shoot Iron Partitioning: A Novel Example of Copper-Iron Crosstalk.	Iron	97-101	laccase 12	Arabidopsis thaliana	70-79
10413045-1	1999	African trypanosomes express a heterodimeric transferrin receptor that mediates iron uptake from the host bloodstream.	Iron	80-84	transferrin receptor	Homo sapiens	45-65
34558857-8	2021	A high-iron diet (2% carbonyl iron) suppressed duodenal DMT1 levels in both wild-type and Hjv-/- mice; however, it did not affect duodenal ferroportin expression in Hjv-/- mice, and only reduced it in wild-type mice.	Iron	7-11	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	56-60
34558857-8	2021	A high-iron diet (2% carbonyl iron) suppressed duodenal DMT1 levels in both wild-type and Hjv-/- mice; however, it did not affect duodenal ferroportin expression in Hjv-/- mice, and only reduced it in wild-type mice.	Iron	30-34	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	56-60
34558857-11	2021	In the Hjv-/- mouse model of hemochromatosis, duodenal ferroportin remains unresponsive to iron but DMT1 is appropriately iron-regulated.	Iron	122-126	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	100-104
34740612-1	2021	Liver sinusoidal endothelial cells (LSECs) derived bone morphogenetic protein 6 (BMP6) and the BMP6/SMAD signaling pathway are essential for expression of hepcidin, the secretion of which is considered the systemic master switch of iron homeostasis.	Iron	232-236	SMAD family member 1	Homo sapiens	100-104
10362817-7	1999	D3 induced a rapid, dose-dependent increase in HK-2 susceptibility to both ATP-depletion/Ca2+-ionophore- and Fe-mediated attack without independently affecting cell integrity or proliferative responses.	Iron	109-111	hexokinase 2	Homo sapiens	47-51
33682565-7	2021	Furthermore, the detailed interaction mechanism towards CYP2J2 was explicated by docking and molecular dynamics, and our results revealed the residue Thr114 and Thr 315 of CYP2J2 were the critical sites of action, moreover the spatial distance between the carbon atom of ligand methylene and Fe atom of iron porphyrin coenzyme was the vital interaction factor towards human CYP2J2.	Iron	292-294	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	56-62
33682565-7	2021	Furthermore, the detailed interaction mechanism towards CYP2J2 was explicated by docking and molecular dynamics, and our results revealed the residue Thr114 and Thr 315 of CYP2J2 were the critical sites of action, moreover the spatial distance between the carbon atom of ligand methylene and Fe atom of iron porphyrin coenzyme was the vital interaction factor towards human CYP2J2.	Iron	292-294	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	172-178
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	121-125	frataxin	Homo sapiens	47-55
33682565-7	2021	Furthermore, the detailed interaction mechanism towards CYP2J2 was explicated by docking and molecular dynamics, and our results revealed the residue Thr114 and Thr 315 of CYP2J2 were the critical sites of action, moreover the spatial distance between the carbon atom of ligand methylene and Fe atom of iron porphyrin coenzyme was the vital interaction factor towards human CYP2J2.	Iron	292-294	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	374-380
33682565-7	2021	Furthermore, the detailed interaction mechanism towards CYP2J2 was explicated by docking and molecular dynamics, and our results revealed the residue Thr114 and Thr 315 of CYP2J2 were the critical sites of action, moreover the spatial distance between the carbon atom of ligand methylene and Fe atom of iron porphyrin coenzyme was the vital interaction factor towards human CYP2J2.	Iron	303-307	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	56-62
33682565-7	2021	Furthermore, the detailed interaction mechanism towards CYP2J2 was explicated by docking and molecular dynamics, and our results revealed the residue Thr114 and Thr 315 of CYP2J2 were the critical sites of action, moreover the spatial distance between the carbon atom of ligand methylene and Fe atom of iron porphyrin coenzyme was the vital interaction factor towards human CYP2J2.	Iron	303-307	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	172-178
33682565-7	2021	Furthermore, the detailed interaction mechanism towards CYP2J2 was explicated by docking and molecular dynamics, and our results revealed the residue Thr114 and Thr 315 of CYP2J2 were the critical sites of action, moreover the spatial distance between the carbon atom of ligand methylene and Fe atom of iron porphyrin coenzyme was the vital interaction factor towards human CYP2J2.	Iron	303-307	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	374-380
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	195-199	frataxin	Homo sapiens	47-55
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	195-199	frataxin	Homo sapiens	47-55
34518636-1	2021	Lipocalin 2 (LCN2), an acute-phase protein produced during acute liver injury, plays an important role in the innate immune response against bacterial infection via iron scavenging.	Iron	165-169	lipocalin 2	Mus musculus	0-11
10332043-4	1999	We show that Yfh1p interacts functionally with yeast mitochondrial intermediate peptidase ( OCT1 gene, YMIP polypeptide), a metalloprotease required for maturation of ferrochelatase and other iron-utilizing proteins.	Iron	192-196	metalloendopeptidase	Saccharomyces cerevisiae S288C	92-96
34518636-1	2021	Lipocalin 2 (LCN2), an acute-phase protein produced during acute liver injury, plays an important role in the innate immune response against bacterial infection via iron scavenging.	Iron	165-169	lipocalin 2	Mus musculus	13-17
10318901-6	1999	Thus, iron homeostasis is indirectly regulated by HFE, a negative modulator of TfR.	Iron	6-10	homeostatic iron regulator	Homo sapiens	50-53
34857271-0	2021	Mg-Fe layered double hydroxides modified titanium enhanced the adhesion of human gingival fibroblasts through regulation of local pH level.	Iron	3-5	phenylalanine hydroxylase	Homo sapiens	130-132
10318901-6	1999	Thus, iron homeostasis is indirectly regulated by HFE, a negative modulator of TfR.	Iron	6-10	transferrin receptor	Homo sapiens	79-82
10319894-0	1999	Direct evidence that mitochondrial iron accumulation occurs in Friedreich ataxia.	Iron	35-39	frataxin	Homo sapiens	63-80
34677911-3	2021	Density functional theory calculations unveil the SnO2- x /Fe2 O3 with a maximum x value has the optimal electronic structure, the metallic Fe generated from Fe2 O3 can markedly reduce the free energy to break Li-O bonds for accelerating subsequent delithiation process of Li2 O. Consequently, the optimized SnO2- x /Fe2 O3 exhibits a remarkably enhanced electrochemical reversibility and reaction kinetics.	Iron	140-142	ATP binding cassette subfamily A member 12	Homo sapiens	273-276
10319894-2	1999	When the gene homologous to FRDA is knocked out in yeast, there is accumulation of iron in mitochondria and reduced respiratory function.	Iron	83-87	frataxin	Homo sapiens	28-32
10319894-3	1999	So far, there is only indirect evidence to support the hypothesis that FRDA is due to accumulation of mitochondrial iron leading to increased production of free radicals.	Iron	116-120	frataxin	Homo sapiens	71-75
34940556-3	2021	In the bone marrow, heme synthesis is mainly controlled by intracellular labile iron by post-transcriptional regulation: translation of ALAS2 mRNA, the first and rate-limiting enzyme of the pathway, is inhibited when iron availability is low.	Iron	80-84	5'-aminolevulinate synthase 2	Homo sapiens	136-141
34940556-3	2021	In the bone marrow, heme synthesis is mainly controlled by intracellular labile iron by post-transcriptional regulation: translation of ALAS2 mRNA, the first and rate-limiting enzyme of the pathway, is inhibited when iron availability is low.	Iron	217-221	5'-aminolevulinate synthase 2	Homo sapiens	136-141
10319894-4	1999	We show here that mitochondrial iron is significantly higher in fibroblasts from patients with FRDA than in control fibroblasts.	Iron	32-36	frataxin	Homo sapiens	95-99
10226041-1	1999	The understanding of iron metabolism at the molecular level has been enormously expanded in recent years by new findings about the functioning of transferrin, the transferrin receptor and ferritin.	Iron	21-25	transferrin receptor	Homo sapiens	163-183
34780475-4	2021	AIM: The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia.	Iron	101-105	bone morphogenetic protein 2	Homo sapiens	78-82
34780475-8	2021	The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050).	Iron	155-159	bone morphogenetic protein 2	Homo sapiens	29-33
10335100-7	1999	Experimental studies have revealed iron accumulation in mitochondria of neurons and cardiomyocytes, suggesting that frataxin plays a determinant role in intramitochondrial iron homeostasis.	Iron	35-39	frataxin	Homo sapiens	116-124
34773648-10	2022	In allergic subjects, stimulation of PBMCs with holoBLG led to a significant increase of intracellular iron in circulating CD14+ cells with significantly lower expression of HLADR and CD86 compared to their stimulation with apoBLG.	Iron	103-107	CD14 antigen	Mus musculus	123-127
10335100-7	1999	Experimental studies have revealed iron accumulation in mitochondria of neurons and cardiomyocytes, suggesting that frataxin plays a determinant role in intramitochondrial iron homeostasis.	Iron	172-176	frataxin	Homo sapiens	116-124
10075667-6	1999	The flavin and iron-sulfur centers of inactivated XO were reduced by dithionite and reoxidized readily with oxygen, and inactivated XDH retained electron transfer activities from NADH to electron acceptors, consistent with the conclusion that the flavin and iron-sulfur centers of the inactivated enzyme both remained intact.	Iron	258-262	xanthine dehydrogenase	Homo sapiens	132-135
34830156-8	2021	mZip14 protein was expressed for the enhancement of iron transport into the cell.	Iron	52-56	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-6
10077577-0	1999	Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster.	Iron	0-4	Ferritin 1 heavy chain homologue	Drosophila melanogaster	58-66
34762046-0	2021	The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice.	Iron	18-22	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	35-40
34762046-2	2021	They are synthesized in the mitochondria as Fe-S intermediates and are exported to the cytoplasm for maturation by the mitochondrial transporter ABCB7.	Iron	44-48	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	145-150
10077577-10	1999	Iron significantly increases the amount of ferritin HCH messages and dramatically shifts the balance toward those messages that lack an IRE and/or have a short 3" UTR.	Iron	0-4	Ferritin 1 heavy chain homologue	Drosophila melanogaster	43-51
34762046-6	2021	While increased intracellular iron was observed in ABCB7-deficient pro-B cells, this did not lead to increased cellular or mitochondrial reactive oxygen species, ferroptosis, or apoptosis.	Iron	30-34	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Mus musculus	51-56
10077577-13	1999	Synthesis of ferritin HCH subunit mRNAs that lack an IRE may be important under conditions of iron overload.	Iron	94-98	Ferritin 1 heavy chain homologue	Drosophila melanogaster	13-21
34346561-12	2021	Mechanistically, iron exacerbated the loss of contractile cerebral vascular smooth muscle cells (VSMCs), aggravated blood-brain barrier (BBB) leakage in Ang II-induced hypertensive mice, and increased glial and MMP9 accumulation after ICH.	Iron	17-21	matrix metallopeptidase 9	Mus musculus	211-215
10077651-0	1999	Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1.	Iron	23-27	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	140-144
10077651-2	1999	We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron.	Iron	223-227	transferrin receptor	Mus musculus	117-120
34215976-7	2021	In addition, Fe3O4/PCC MNPs could be reused up to 8 cycles for the MB degradation with negligible iron leaching of lower than 1.5 mg L-1.	Iron	98-102	crystallin gamma D	Homo sapiens	19-22
10077651-2	1999	We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron.	Iron	318-322	transferrin receptor	Mus musculus	117-120
10037716-0	1999	The accessibility of iron at the active site of recombinant human phenylalanine hydroxylase to water as studied by 1H NMR paramagnetic relaxation.	Iron	21-25	phenylalanine hydroxylase	Homo sapiens	66-91
10037716-7	1999	Thus, the recombinant human PAH appears to have a more solvent-accessible catalytic iron than the rat enzyme, in which the water coordinated to the metal is slowly exchanging with the solvent.	Iron	84-88	phenylalanine hydroxylase	Homo sapiens	28-31
10349514-9	1999	Alternate splicing produces soluble HFE that may have a unique function to regulate cellular iron transport.	Iron	93-97	homeostatic iron regulator	Homo sapiens	36-39
10319264-3	1999	The highest level of liver iron was found in the beta 2-microglobulin knockout (beta 2m-/-) mice followed by the TCR-delta knockout (TCR delta-/-) animals.	Iron	27-31	beta-2 microglobulin	Mus musculus	49-69
10319264-3	1999	The highest level of liver iron was found in the beta 2-microglobulin knockout (beta 2m-/-) mice followed by the TCR-delta knockout (TCR delta-/-) animals.	Iron	27-31	beta-2 microglobulin	Mus musculus	80-90
9926414-0	1999	Iron regulation and pathogenicity in Erwinia chrysanthemi 3937: role of the Fur repressor protein.	Iron	0-4	ferric iron uptake transcriptional regulator	Dickeya dadantii 3937	76-79
9926414-7	1999	In a fur background, transcriptional lacZ fusions to genes belonging to the E. chrysanthemi high affinity iron transport systems were constitutively expressed.	Iron	106-110	ferric iron uptake transcriptional regulator	Dickeya dadantii 3937	5-8
9926414-10	1999	In the presence of iron, pelD and pelE transcription levels were higher in the fur mutant than in the parental strain.	Iron	19-23	ferric iron uptake transcriptional regulator	Dickeya dadantii 3937	79-82
9926414-12	1999	These findings indicate that, in E. chrysanthemi 3937, (i) Fur negatively controls iron transport and genes encoding PelD and PelE, and (ii) additional factor(s) mediate iron regulation of the pel genes.	Iron	83-87	ferric iron uptake transcriptional regulator	Dickeya dadantii 3937	59-62
9926414-12	1999	These findings indicate that, in E. chrysanthemi 3937, (i) Fur negatively controls iron transport and genes encoding PelD and PelE, and (ii) additional factor(s) mediate iron regulation of the pel genes.	Iron	170-174	ferric iron uptake transcriptional regulator	Dickeya dadantii 3937	59-62
10206099-4	1999	It is of clinical importance to know the quantitative effect of iron-deficient erythropoiesis on the levels of HbA2 in order to be able to determine which iron-deficient patients with normal HbA2 levels have to be retested after iron therapy in thalassaemia screening programmes.	Iron	64-68	hemoglobin subunit alpha 2	Homo sapiens	111-115
9882459-0	1999	Mutational analysis of loading of iron into rat liver ferritin by ceruloplasmin.	Iron	34-38	ceruloplasmin	Rattus norvegicus	66-79
9882459-1	1999	Site-directed mutagenesis was used to investigate the loading of iron into rat liver ferritin by ceruloplasmin.	Iron	65-69	ceruloplasmin	Rattus norvegicus	97-110
9882459-3	1999	Mutation Y34F affected the rate of iron loading by ceruloplasmin and incorporation of the oxidized iron into the core.	Iron	35-39	ceruloplasmin	Rattus norvegicus	51-64
9882459-6	1999	Additional changes in the L chain involving the BC loop suggest that the entire BC loop is involved in the association of ferritin with ceruloplasmin, increasing its ferroxidase activity and the rate of iron loading into ferritin.	Iron	203-207	ceruloplasmin	Rattus norvegicus	136-149
10989661-17	1999	The mitochondrial iron accumulation, defective respiratory chain activity and aconitase dysfunction suggest that frataxin may be involved in mitochondrial iron regulation.	Iron	18-22	frataxin	Homo sapiens	113-121
10989661-17	1999	The mitochondrial iron accumulation, defective respiratory chain activity and aconitase dysfunction suggest that frataxin may be involved in mitochondrial iron regulation.	Iron	155-159	frataxin	Homo sapiens	113-121
11399563-3	1999	The HFE mutation, C282Y, responsible for most cases of HH is found in as many as 8-18% of people of European descent; 6-32 per 1000 are therefore homozygous, but only a variable proportion accumulate enough iron to develop organ damage with the associated clinical manifestations.	Iron	207-211	homeostatic iron regulator	Homo sapiens	4-7
34371060-1	2021	BACKGROUND: The study aimed to screen mutation of human homeostatic iron regulator (HFE) in colorectal carcinoma (CRC) and detect their associations with clinicopathological parameters.	Iron	68-72	homeostatic iron regulator	Homo sapiens	84-87
34417948-1	2021	Lipocalin 2 (LCN2), an immunomodulator, regulates various cellular processes such as iron transport and defense against bacterial infection.	Iron	85-89	lipocalin 2	Mus musculus	0-11
34417948-1	2021	Lipocalin 2 (LCN2), an immunomodulator, regulates various cellular processes such as iron transport and defense against bacterial infection.	Iron	85-89	lipocalin 2	Mus musculus	13-17
34215448-1	2021	A recent study suggested that the p.H63D variant in HFE, a gene involved in iron homeostasis, may modify alpha-synuclein pathology, the pathological hallmark of Parkinson"s disease (PD).	Iron	76-80	homeostatic iron regulator	Homo sapiens	52-55
34537326-8	2021	We found iron accumulation and perturbed iron-ferritin interaction in substantia nigra, putamen and cerebellum of aged PLP-alphasyn mice.	Iron	9-13	proteolipid protein (myelin) 1	Mus musculus	119-122
34537326-8	2021	We found iron accumulation and perturbed iron-ferritin interaction in substantia nigra, putamen and cerebellum of aged PLP-alphasyn mice.	Iron	41-45	proteolipid protein (myelin) 1	Mus musculus	119-122
34718778-10	2022	These data indicate that NFU4 and NFU5 have a more specific function than previously thought, most likely providing Fe-S clusters to lipoyl synthase.	Iron	116-118	NFU domain protein 5	Arabidopsis thaliana	34-38
34778662-4	2021	One such target could be the transferrin receptor, a glycoprotein receptor that is expressed many-folds on rapidly growing cells due to the greater demand of iron.	Iron	158-162	transferrin receptor	Mus musculus	29-49
34786173-13	2021	CONCLUSION: Iron directly blocks hepatocellular hepcidin signaling through the BMP/SMAD pathway but independent of STAT3.	Iron	12-16	SMAD family member 1	Homo sapiens	83-87
34703229-11	2021	The enrichment rate of SPIONs@DFK-SBP-M13 assembly was 13.9 times higher than free SPIONs at 0.5 h, and intracellular Fe content was 3.6 times higher at 1 h. Furthermore, the DFK peptides favored cathepsin B to cleave SPIONs from the M13 templates resulting in release of SPIONs inside cells.	Iron	118-120	selenium binding protein 1	Homo sapiens	34-37
34609882-4	2021	Here, we propose a methodology for investigating the adhesion of the SARS CoV-2 spike glycoprotein on common inorganic surfaces such as aluminum, copper, iron, silica, and ceria oxides as well as metallic gold.	Iron	154-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	80-85
34733841-10	2021	Overall, our results reveal a previously uncharacterized mechanism of ALKBH5 in protecting against PDAC through modulating regulators of iron metabolism and underscore the multifaceted role of m6A in pancreatic cancer.	Iron	137-141	alkB homolog 5, RNA demethylase	Homo sapiens	70-76
34722998-2	2021	The iron precipitate was obtained from mineral sulfide bioleaching and characterized using SEM/EDS, XRD, FTIR, BET, TGA, and pHpzc analyses.	Iron	4-8	delta/notch like EGF repeat containing	Homo sapiens	111-114
34722998-2	2021	The iron precipitate was obtained from mineral sulfide bioleaching and characterized using SEM/EDS, XRD, FTIR, BET, TGA, and pHpzc analyses.	Iron	4-8	T-box transcription factor 1	Homo sapiens	116-119
34648132-6	2021	Furthermore, a lack of miR-7-5p expression led to increased levels of transferrin receptor, promoting the uptake of iron and production of lipid reactive oxygen species and demonstrating that DOX-induced ferroptosis occurs in AC16 cells.	Iron	116-120	transferrin receptor	Homo sapiens	70-90
34607432-2	2021	Herein, a monolithic iron metal-organic gel/bacterial cellulose (denoted as Fe-MOG/BC) composite has been successfully fabricated based on an ultrafast, scalable, aqueous-based synthetic strategy at room temperature.	Iron	21-31	myelin oligodendrocyte glycoprotein	Homo sapiens	79-82
34612205-1	2021	Most eukaryotic cells retain a mitochondrial fatty acid synthesis (FASII) pathway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a soluble scaffold for acyl chain synthesis and biochemically couple FASII activity to mitochondrial electron transport chain (ETC) assembly and Fe-S cluster biogenesis.	Iron	319-323	vitamin A enhanced cleft palate	Mus musculus	110-114
34612205-5	2021	Biochemical studies reveal that Plasmodium mACP binds and stabilizes the Isd11-Nfs1 complex required for Fe-S cluster biosynthesis, despite lacking the Ppant group required for this association in other eukaryotes, and knockdown of parasite mACP causes loss of Nfs1 and the Rieske Fe-S protein in ETC Complex III.	Iron	105-109	vitamin A enhanced cleft palate	Mus musculus	43-47
34612205-5	2021	Biochemical studies reveal that Plasmodium mACP binds and stabilizes the Isd11-Nfs1 complex required for Fe-S cluster biosynthesis, despite lacking the Ppant group required for this association in other eukaryotes, and knockdown of parasite mACP causes loss of Nfs1 and the Rieske Fe-S protein in ETC Complex III.	Iron	105-109	NFS1 cysteine desulfurase	Homo sapiens	79-83
34612205-7	2021	This discovery unveils an evolutionary driving force to retain interaction of mitochondrial Fe-S cluster biogenesis with ACP independent of its eponymous function in FASII.	Iron	92-96	vitamin A enhanced cleft palate	Mus musculus	121-124
10580641-0	1999	The hereditary hemochromatosis gene (HFE): a MHC class I-like gene that functions in the regulation of iron homeostasis.	Iron	103-107	homeostatic iron regulator	Homo sapiens	37-40
34214849-8	2021	Dosing zero-valent iron (ZVI) could also promote AO7 decolorization by 1.7 times since the addition of ZVI could provide a proliferative environment for EX-AO7 growth.	Iron	19-23	ring finger protein 25	Homo sapiens	49-52
34214849-8	2021	Dosing zero-valent iron (ZVI) could also promote AO7 decolorization by 1.7 times since the addition of ZVI could provide a proliferative environment for EX-AO7 growth.	Iron	19-23	ring finger protein 25	Homo sapiens	156-159
10580641-6	1999	In addition, with the identification of the transferrin receptor as a protein capable of interacting with HFE we are now beginning to understand how a protein with the structural characteristics of an MHC class I molecule can influence cellular iron homeostasis.	Iron	245-249	homeostatic iron regulator	Homo sapiens	106-109
9858603-1	1999	Iron regulatory protein 1 (IRP-1) binding to an iron-responsive element (IRE) located close to the cap structure of mRNAs represses translation by precluding the recruitment of the small ribosomal subunit to these mRNAs.	Iron	48-52	aconitase 1	Homo sapiens	0-25
34600467-8	2021	For all evaluated RG, Tfrc expression significantly increased in iron-deficient animal livers compared to the iron-replete pair-fed controls; however, the relative induction varied nearly 4-fold between the most suitable (Rpl19) and least suitable (Gapdh) RG.	Iron	65-69	transferrin receptor	Rattus norvegicus	22-26
9858603-1	1999	Iron regulatory protein 1 (IRP-1) binding to an iron-responsive element (IRE) located close to the cap structure of mRNAs represses translation by precluding the recruitment of the small ribosomal subunit to these mRNAs.	Iron	48-52	aconitase 1	Homo sapiens	27-32
10473283-7	1999	The highest levels of Atox1 message consists of distinct neuronal subtypes that are also characterized by their high levels of metals like copper, iron, and zinc, which include the pyramidal neurons of the cerebral cortex and hippocampus in addition to the neurons of the locus coeruleus.	Iron	147-151	antioxidant 1 copper chaperone	Rattus norvegicus	22-27
34324979-1	2021	The knockout (KO) of the cystine transporter xCT causes ferroptosis, a type of iron-dependent necrotic cell death, in mouse embryonic fibroblasts, but this does not occur in macrophages.	Iron	79-83	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	45-48
34468013-3	2021	Calcium chelators have been reported to inhibit iron influx via modulating transferrin receptor protein 1 internalization, and they have been identified as a potential approach to the treatment of iron overload-induced diseases.	Iron	48-52	transferrin receptor	Homo sapiens	75-105
9950149-7	1999	IRP-1 activity and TfR Bmax for diferric transferrin were greater in the iron-deficient group (P&lt;0.05).	Iron	73-77	aconitase 1	Homo sapiens	0-5
34467981-11	2021	On the other hand, VA increased the expression of Ascl2 (P = 0.001) although the interaction of VA and iron (P < 0.05) had an effect on the expression of secreted phosphoprotein 1 (Spp1) and Bmi1.	Iron	103-107	secreted phosphoprotein 1	Sus scrofa	154-179
34467981-11	2021	On the other hand, VA increased the expression of Ascl2 (P = 0.001) although the interaction of VA and iron (P < 0.05) had an effect on the expression of secreted phosphoprotein 1 (Spp1) and Bmi1.	Iron	103-107	secreted phosphoprotein 1	Sus scrofa	181-185
34467981-12	2021	In addition, VA decreased the gene or mRNA expression of aconitase 1 (Aco1; P < 0.001), transferrin receptor (TFRC; P = 0.001), and solute carrier family 11 member 2 (DMT1; P = 0.003) in the Iron Reactive Element/Iron Regulatory Protein (IRE/IRP) signaling pathway although iron and the interaction of VA and iron had no effect on the genes" expression.	Iron	191-195	solute carrier family 11 member 2	Sus scrofa	167-171
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	28-30	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	130-137
9950149-8	1999	IRP-1 activity correlated inversely with cord serum ferritin (r=0.75; P&lt;0.01) and placental non-heme iron (r=0.61; P=0.05) concentration.	Iron	104-108	aconitase 1	Homo sapiens	0-5
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	64-66	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	130-137
9950149-9	1999	Placental IRP-1 activity is directly related to TfR mRNA concentration and is more highly expressed in iron-deficient placentae.	Iron	103-107	aconitase 1	Homo sapiens	10-15
9826488-2	1998	The IRP-IRE interactions are regulated by the intracellular iron level by affecting the binding affinity, synthesis and stability of the IRPs.	Iron	60-64	Wnt family member 2	Homo sapiens	4-7
34570359-3	2022	The HFE gene encodes for a protein involved in iron metabolism, while genetic variants in HFE have been associated with hereditary hemochromatosis (HH), an iron overload disorder.	Iron	47-51	homeostatic iron regulator	Homo sapiens	4-7
9836708-10	1998	Our data provide evidence for a protective role of the C282Y mutation in the HFE gene against iron deficiency in young women and suggest that a more efficient utilization of nutritional iron may have contributed to the high prevalence of the mutation in Caucasian populations.	Iron	94-98	homeostatic iron regulator	Homo sapiens	77-80
34570359-3	2022	The HFE gene encodes for a protein involved in iron metabolism, while genetic variants in HFE have been associated with hereditary hemochromatosis (HH), an iron overload disorder.	Iron	156-160	homeostatic iron regulator	Homo sapiens	4-7
34570359-3	2022	The HFE gene encodes for a protein involved in iron metabolism, while genetic variants in HFE have been associated with hereditary hemochromatosis (HH), an iron overload disorder.	Iron	156-160	homeostatic iron regulator	Homo sapiens	90-93
34684967-0	2021	A Review on the Wear, Corrosion and High-Temperature Resistant Properties of Wire Arc-Sprayed Fe-Based Coatings.	Iron	94-96	activity regulated cytoskeleton associated protein	Homo sapiens	82-85
34684967-2	2021	The rapid progress of cored wire technology in arc-spraying has increased possibilities for the preparation of new Fe-based coating materials with enhanced properties by adding reinforcement particles and alloying elements to suit the different applications.	Iron	115-117	activity regulated cytoskeleton associated protein	Homo sapiens	47-50
34684967-5	2021	This review discusses the research status and developments of the arc-sprayed Fe-based coatings.	Iron	78-80	activity regulated cytoskeleton associated protein	Homo sapiens	66-69
9870556-1	1998	Iron containing 3-Hydroxyanthranilate oxidase (3HAO) converts 3-hydroxyanthranilate (3HAA) and dioxygen into a precursor which spontaneously converts to quinolinic acid (QA).	Iron	0-4	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	16-45
34684967-6	2021	The study specifically reviews the wear behavior, corrosion analysis, and high-temperature resistant properties of arc-sprayed Fe-based coatings, aiming to develop an understanding of the protection mechanisms for Fe-based coatings.	Iron	127-129	activity regulated cytoskeleton associated protein	Homo sapiens	115-118
34573089-2	2021	Iron-sulfur (Fe-S) clusters are critical cofactors that aid in a wide variety of cellular functions (e.g., DNA metabolism and electron transport).	Iron	13-17	activation induced cytidine deaminase	Homo sapiens	56-59
9870556-1	1998	Iron containing 3-Hydroxyanthranilate oxidase (3HAO) converts 3-hydroxyanthranilate (3HAA) and dioxygen into a precursor which spontaneously converts to quinolinic acid (QA).	Iron	0-4	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	47-51
9870556-10	1998	Iron-staining of 3HAO, separated by gel electrophoresis after partial purification by FPLC, showed that loss of iron and loss of enzyme activity during HBO exposure were correlated.	Iron	0-4	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	17-21
9870556-10	1998	Iron-staining of 3HAO, separated by gel electrophoresis after partial purification by FPLC, showed that loss of iron and loss of enzyme activity during HBO exposure were correlated.	Iron	112-116	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	17-21
34575794-4	2021	Interestingly, we found that nitrogen starvation resulted in lower iron uptake activity than that of wild-type cells without downregulation of the genes involved in the high-affinity iron uptake system FET3/FTR1.	Iron	183-187	ferroxidase FET3	Saccharomyces cerevisiae S288C	202-206
9822678-5	1998	The membrane extrinsic domain, consisting of Sdh1p and Sdh2p, contains a covalent FAD cofactor and three iron-sulfur clusters.	Iron	105-109	succinate dehydrogenase flavoprotein subunit SDH1	Saccharomyces cerevisiae S288C	45-50
9822678-5	1998	The membrane extrinsic domain, consisting of Sdh1p and Sdh2p, contains a covalent FAD cofactor and three iron-sulfur clusters.	Iron	105-109	succinate dehydrogenase iron-sulfur protein subunit SDH2	Saccharomyces cerevisiae S288C	55-60
34499019-2	2021	X-ray diffraction (XRD), nitrogen adsorption-desorption (BET), X-ray photoelectron spectroscopy (XPS) results showed that iron and titanium successfully doped into the skeleton of gamma-Al2O3, uniform distribution, maintain the ordered mesoporous structure of gamma-Al2O3, with larger specific surface area.	Iron	122-126	delta/notch like EGF repeat containing	Homo sapiens	57-60
9811853-2	1998	gef1 mutants have a defect in the high-affinity iron transport system, which relies on the cell surface multicopper oxidase Fet3p.	Iron	48-52	ferroxidase FET3	Saccharomyces cerevisiae S288C	124-129
9784581-2	1998	Zrt1, Zrt2 and Zip1-4 are probably zinc transporters in Saccharomyces cerevisiae and Arabidopsis thaliana whereas Irt1 appears to play a role in iron uptake in A. thaliana.	Iron	145-149	Zip1p	Saccharomyces cerevisiae S288C	15-21
34436907-0	2021	Fabrication of Nanoflower-like MCoP (M = Fe and Ni) Composites for High-Performance Supercapacitors.	Iron	41-43	MCOP1	Homo sapiens	31-35
34436907-2	2021	In the present study, nanoflower-like MCoP (M = Ni and Fe) composites were successfully fabricated on Ni foam (denoted as NF@MCoP) by a cost-effective hydrothermal and low-temperature phosphating method.	Iron	55-57	MCOP1	Homo sapiens	38-42
34436907-2	2021	In the present study, nanoflower-like MCoP (M = Ni and Fe) composites were successfully fabricated on Ni foam (denoted as NF@MCoP) by a cost-effective hydrothermal and low-temperature phosphating method.	Iron	55-57	MCOP1	Homo sapiens	125-129
9741592-0	1998	Oxidative damage to sarcoplasmic reticulum Ca2+-ATPase AT submicromolar iron concentrations: evidence for metal-catalyzed oxidation.	Iron	72-76	dynein axonemal heavy chain 8	Homo sapiens	48-54
9741592-5	1998	The present study aims at further characterizing the mechanism of inhibition of the Ca2+-ATPase by oxygen reactive species at Fe2+ concentrations possibly found in pathological conditions of iron overload.	Iron	191-195	dynein axonemal heavy chain 8	Homo sapiens	89-95
34610701-8	2021	In addition to their roles with steroidogenic mitochondrial P450s, Fdx and FdxR participate in the synthesis of iron-sulfur clusters used by many enzymes.	Iron	112-116	ferredoxin reductase	Homo sapiens	75-79
9724742-1	1998	Iron regulatory protein-1 (IRP-1), a central cytoplasmic regulator of cellular iron metabolism, is rapidly activated by oxidative stress to bind to mRNA iron-responsive elements.	Iron	79-83	aconitase 1	Homo sapiens	0-25
9724742-1	1998	Iron regulatory protein-1 (IRP-1), a central cytoplasmic regulator of cellular iron metabolism, is rapidly activated by oxidative stress to bind to mRNA iron-responsive elements.	Iron	79-83	aconitase 1	Homo sapiens	27-32
34604849-4	2021	Density functional theory and ab initio calculations, which successfully reproduce spectroscopic parameters, predict a flat potential energy surface of an eta2-O2 motif binding to the iron center regarding the O-O distance.	Iron	184-188	DNA polymerase iota	Homo sapiens	155-159
9724742-1	1998	Iron regulatory protein-1 (IRP-1), a central cytoplasmic regulator of cellular iron metabolism, is rapidly activated by oxidative stress to bind to mRNA iron-responsive elements.	Iron	153-157	aconitase 1	Homo sapiens	0-25
9724742-1	1998	Iron regulatory protein-1 (IRP-1), a central cytoplasmic regulator of cellular iron metabolism, is rapidly activated by oxidative stress to bind to mRNA iron-responsive elements.	Iron	153-157	aconitase 1	Homo sapiens	27-32
9923008-1	1998	We used the Ussing chamber model to study heme iron absorption by rat duodenal mucosa.	Iron	47-51	HEME	Bos taurus	42-46
34291615-0	2021	Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function in healthy adults.	Iron	54-58	homeostatic iron regulator	Homo sapiens	17-20
34291615-2	2021	Mutations in the HFE gene are associated with iron dyshomeostasis and are risk factors for peripheral iron overload.	Iron	102-106	homeostatic iron regulator	Homo sapiens	17-20
34291615-6	2021	RESULTS: Independent of age, carriers of either C282Y and/or H63D (HFE-pos group, n = 66) showed a higher load of iron in putamen than non-carriers (HFE-neg group, n = 142), as well as higher transferrin saturation and lower transferrin and transferrin receptors in blood.	Iron	114-118	homeostatic iron regulator	Homo sapiens	67-70
34291615-6	2021	RESULTS: Independent of age, carriers of either C282Y and/or H63D (HFE-pos group, n = 66) showed a higher load of iron in putamen than non-carriers (HFE-neg group, n = 142), as well as higher transferrin saturation and lower transferrin and transferrin receptors in blood.	Iron	114-118	homeostatic iron regulator	Homo sapiens	149-152
34291615-10	2021	CONCLUSION: Our findings suggest that HFE status is characterized by higher regional brain iron load across adulthood, and support the presence of a modulatory effect of HFE status on the relationships between iron load and cognition.	Iron	91-95	homeostatic iron regulator	Homo sapiens	38-41
34291615-10	2021	CONCLUSION: Our findings suggest that HFE status is characterized by higher regional brain iron load across adulthood, and support the presence of a modulatory effect of HFE status on the relationships between iron load and cognition.	Iron	210-214	homeostatic iron regulator	Homo sapiens	38-41
34291615-10	2021	CONCLUSION: Our findings suggest that HFE status is characterized by higher regional brain iron load across adulthood, and support the presence of a modulatory effect of HFE status on the relationships between iron load and cognition.	Iron	210-214	homeostatic iron regulator	Homo sapiens	170-173
9923008-2	1998	Heme iron was obtained by enzymic digestion of bovine haemoglobin and concentration of heme (HPH).	Iron	5-9	HEME	Bos taurus	0-4
34386079-0	2021	Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma.	Iron	70-74	aconitase 1	Homo sapiens	0-25
9923008-2	1998	Heme iron was obtained by enzymic digestion of bovine haemoglobin and concentration of heme (HPH).	Iron	5-9	HEME	Bos taurus	87-91
9923008-8	1998	In the in vitro model using rat digestive mucosa, heme iron appeared to be an efficiently used source of iron, which might prevent its accumulation by gut when supplied in excess.	Iron	55-59	HEME	Bos taurus	50-54
34386079-5	2021	Iron regulatory protein (IRP)1 and 2 play important roles in maintaining iron homeostasis, but their functions in ferroptosis have not been investigated.	Iron	73-77	aconitase 1	Homo sapiens	0-36
34386079-9	2021	Further, erastin and RSL3 promoted the transition of aconitase 1 to IRP1, which regulated downstream iron metabolism proteins, including transferrin receptor (TFRC), ferroportin (FPN) and ferritin heavy chain 1 (FTH1).	Iron	101-105	aconitase 1	Homo sapiens	53-64
9923008-8	1998	In the in vitro model using rat digestive mucosa, heme iron appeared to be an efficiently used source of iron, which might prevent its accumulation by gut when supplied in excess.	Iron	105-109	HEME	Bos taurus	50-54
34386079-9	2021	Further, erastin and RSL3 promoted the transition of aconitase 1 to IRP1, which regulated downstream iron metabolism proteins, including transferrin receptor (TFRC), ferroportin (FPN) and ferritin heavy chain 1 (FTH1).	Iron	101-105	aconitase 1	Homo sapiens	68-72
9712830-3	1998	We demonstrate that mutations that result in a defective high affinity iron transport system, such as a deletion in the surface ferroxidase FET3, also result in increased metal sensitivity independent of vacuolar function.	Iron	71-75	ferroxidase FET3	Saccharomyces cerevisiae S288C	140-144
34386079-9	2021	Further, erastin and RSL3 promoted the transition of aconitase 1 to IRP1, which regulated downstream iron metabolism proteins, including transferrin receptor (TFRC), ferroportin (FPN) and ferritin heavy chain 1 (FTH1).	Iron	101-105	transferrin receptor	Homo sapiens	137-157
34386079-9	2021	Further, erastin and RSL3 promoted the transition of aconitase 1 to IRP1, which regulated downstream iron metabolism proteins, including transferrin receptor (TFRC), ferroportin (FPN) and ferritin heavy chain 1 (FTH1).	Iron	101-105	transferrin receptor	Homo sapiens	159-163
34386079-11	2021	Collectively, the present findings indicate that IRP1 plays an essential role in erastin- and RSL3-induced ferroptosis by regulating iron homeostasis.	Iron	133-137	aconitase 1	Homo sapiens	49-53
34573347-1	2021	Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2.	Iron	0-4	aconitase 1	Homo sapiens	121-125
34573347-1	2021	Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2.	Iron	96-100	aconitase 1	Homo sapiens	121-125
9694900-1	1998	Previous studies demonstrated that SFT (Stimulator of Fe Transport) facilitates both transferrin and nontransferrin-bound iron uptake in HeLa cells (Yu, J., and Wessling-Resnick, M. (1998) J. Biol.	Iron	122-126	ubiquitin conjugating enzyme E2 D1	Homo sapiens	35-38
9694900-1	1998	Previous studies demonstrated that SFT (Stimulator of Fe Transport) facilitates both transferrin and nontransferrin-bound iron uptake in HeLa cells (Yu, J., and Wessling-Resnick, M. (1998) J. Biol.	Iron	122-126	ubiquitin conjugating enzyme E2 D1	Homo sapiens	40-66
34157442-11	2021	Inhibition of mTORC1 led to the downregulation of GPX4 which promoted Lap induced ferroptosis as evidenced by increase of ROS, MDA, Fe 2+ and decrease of GSH.	Iron	132-134	CREB regulated transcription coactivator 1	Mus musculus	14-20
9694900-12	1998	However, 55Fe-binding studies reveal that the ability of SFT to bind and mediate transport of extracellular iron is defective in mutants with Glu --&gt; Ala conversions in this motif.	Iron	108-112	ubiquitin conjugating enzyme E2 D1	Homo sapiens	57-60
9694900-13	1998	Curiously, we also find that depletion of intracellular iron by desferrioxamine impairs SFT transport and iron-binding functions.	Iron	56-60	ubiquitin conjugating enzyme E2 D1	Homo sapiens	88-91
9714810-5	1998	Friedreich"s ataxia is caused by an expanded GAA repeat resulting in dysfunction of frataxin, a nuclear encoded mitochondrial protein involved in mitochondrial iron transport.	Iron	160-164	frataxin	Homo sapiens	84-92
34492978-3	2021	A supported Pt catalyst on Fe-W-O amorphous nanosheets (denoted as Pt/a-Fe-W-O) was synthesized using a one-step solvothermal method.	Iron	27-29	pre T cell antigen receptor alpha	Homo sapiens	67-71
34492978-3	2021	A supported Pt catalyst on Fe-W-O amorphous nanosheets (denoted as Pt/a-Fe-W-O) was synthesized using a one-step solvothermal method.	Iron	72-74	pre T cell antigen receptor alpha	Homo sapiens	67-71
9739406-12	1998	The increased number of malignant endocervical glands expressing TfR may indicate a special requirement for Tf and the iron that it carries.	Iron	119-123	transferrin receptor	Homo sapiens	65-68
34389031-17	2021	CONCLUSIONS: Collectively, we identified iron starvation through TFRC-mediated iron competition drives functional immunosuppressive polarization of TAM, providing new insight into the interconnection between iron metabolism and tumor immunity.	Iron	208-212	transferrin receptor	Homo sapiens	65-69
9747913-12	1998	Frataxin, the protein that is mutated, might normally be responsible for mitochondrial iron homeostasis in tissues that are affected by the disease.	Iron	87-91	frataxin	Homo sapiens	0-8
34310123-1	2021	The human mitochondrial protein, mitoNEET (mNT), belongs to the family of small (2Fe-2S) NEET proteins that bind their iron-sulfur clusters with a novel and characteristic 3Cys:1His coordination motif.	Iron	119-123	max binding protein	Mus musculus	43-46
34310123-2	2021	mNT has been implicated in the regulation of lipid and glucose metabolisms, iron/reactive oxygen species homeostasis, cancer, and possibly Parkinson"s disease.	Iron	76-80	max binding protein	Mus musculus	0-3
9647667-1	1998	We showed previously that ceruloplasmin associates with the H chain of rat liver ferritin during iron loading into ferritin such that the iron oxidized by ceruloplasmin was deposited into ferritin [S.-H. Juan et al.	Iron	97-101	ceruloplasmin	Rattus norvegicus	26-39
34362891-5	2021	By the Paleoproterozoic, they became genetically capable of using iron, nickel, and manganese as cofactors (FeSOD, NiSOD, and MnSOD respectively).	Iron	66-70	superoxide dismutase 2	Homo sapiens	126-131
34190396-4	2021	Further studies demonstrated that iron overload could promote the senescence of hepatocyte, whereas the overexpression of Yes-associated protein (YAP) could blunt iron overload and alleviate the senescence of hepatocyte.	Iron	163-167	Yes1 associated transcriptional regulator	Homo sapiens	122-144
34190396-4	2021	Further studies demonstrated that iron overload could promote the senescence of hepatocyte, whereas the overexpression of Yes-associated protein (YAP) could blunt iron overload and alleviate the senescence of hepatocyte.	Iron	163-167	Yes1 associated transcriptional regulator	Homo sapiens	146-149
34190396-7	2021	In conclusion, these data suggested that inhibition of MAYA could up-regulate YAP, which might repress hepatocyte senescence through modulating iron overload.	Iron	144-148	Yes1 associated transcriptional regulator	Homo sapiens	78-81
9647667-1	1998	We showed previously that ceruloplasmin associates with the H chain of rat liver ferritin during iron loading into ferritin such that the iron oxidized by ceruloplasmin was deposited into ferritin [S.-H. Juan et al.	Iron	138-142	ceruloplasmin	Rattus norvegicus	26-39
9647667-1	1998	We showed previously that ceruloplasmin associates with the H chain of rat liver ferritin during iron loading into ferritin such that the iron oxidized by ceruloplasmin was deposited into ferritin [S.-H. Juan et al.	Iron	138-142	ceruloplasmin	Rattus norvegicus	155-168
34395447-3	2021	In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism.	Iron	117-121	tumor protein p73	Homo sapiens	100-103
9647667-7	1998	Two of the peptides, CP-4 and CP-6, were found to inhibit iron loading into the recombinant ferritin H chain homopolymer (rH-Ft) by ceruloplasmin.	Iron	58-62	surfactant protein D	Rattus norvegicus	21-25
9647667-7	1998	Two of the peptides, CP-4 and CP-6, were found to inhibit iron loading into the recombinant ferritin H chain homopolymer (rH-Ft) by ceruloplasmin.	Iron	58-62	ceruloplasmin	Rattus norvegicus	132-145
9647667-8	1998	The extent of inhibition of iron loading into ferritin by ceruloplasmin by CP-6, but not CP-4, varied with pH, whereas the inhibitory effect remained constant in increasing concentrations of NaCl.	Iron	28-32	ceruloplasmin	Rattus norvegicus	58-71
34440336-1	2021	HFE hemochromatosis is characterized by increased iron absorption and iron overload due to variants of the iron-regulating HFE gene.	Iron	50-54	homeostatic iron regulator	Homo sapiens	123-126
34440336-1	2021	HFE hemochromatosis is characterized by increased iron absorption and iron overload due to variants of the iron-regulating HFE gene.	Iron	70-74	homeostatic iron regulator	Homo sapiens	123-126
34440336-1	2021	HFE hemochromatosis is characterized by increased iron absorption and iron overload due to variants of the iron-regulating HFE gene.	Iron	107-111	homeostatic iron regulator	Homo sapiens	123-126
9647667-14	1998	Only the BC loop of ferritin H chain decreased the amount of iron loading into ferritin by ceruloplasmin.	Iron	61-65	ceruloplasmin	Rattus norvegicus	91-104
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	9-13	transferrin receptor	Homo sapiens	146-166
34439443-11	2021	High transferrin saturation as a sign of iron overload and a low SHP concentration as a sign of redox imbalance in obese patients might reflect underlying mechanisms that could in part explain the associations of iron overload and obesity with CRA.	Iron	213-217	nuclear receptor subfamily 0 group B member 2	Homo sapiens	65-68
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	9-13	transferrin receptor	Homo sapiens	168-171
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	42-46	transferrin receptor	Homo sapiens	146-166
34349782-8	2021	Interestingly, a high proportion of patients were heterozygous carriers for two variants in HFE gene, otherwise pathogenic for the condition of iron overload.	Iron	144-148	homeostatic iron regulator	Homo sapiens	92-95
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	42-46	transferrin receptor	Homo sapiens	168-171
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	42-46	transferrin receptor	Homo sapiens	146-166
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	42-46	transferrin receptor	Homo sapiens	168-171
34192687-3	2021	The results also show that Fe doping at Zn sites has a pronounced effect on the electrical transport property together with the V-V distance, accompanied by a decreasing magnetic transition temperature, TN.	Iron	27-29	C-type lectin domain family 3 member B	Homo sapiens	203-205
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	42-46	transferrin receptor	Homo sapiens	146-166
9668619-2	1998	Cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which bind to iron-responsive elements (IRE) of mRNAs for ferritin and transferrin receptor (TfR) modulating iron uptake and sequestration, respectively.	Iron	42-46	transferrin receptor	Homo sapiens	168-171
9668619-3	1998	Although iron is the main regulator of IRP activity, IRP is also influenced by other factors, including the redox state.	Iron	9-13	Wnt family member 2	Homo sapiens	39-42
9668619-11	1998	Conceivably, downregulation of IRP activity by O2 and H2O2 may facilitate iron sequestration into ferritin, thus limiting the pro-oxidant challenge of iron.	Iron	74-78	Wnt family member 2	Homo sapiens	31-34
9668619-11	1998	Conceivably, downregulation of IRP activity by O2 and H2O2 may facilitate iron sequestration into ferritin, thus limiting the pro-oxidant challenge of iron.	Iron	151-155	Wnt family member 2	Homo sapiens	31-34
34212661-7	2021	In addition, pH exhibited a significant negative correlation with Fe and Fe nanoparticles.	Iron	66-68	phenylalanine hydroxylase	Homo sapiens	13-15
34212661-7	2021	In addition, pH exhibited a significant negative correlation with Fe and Fe nanoparticles.	Iron	73-75	phenylalanine hydroxylase	Homo sapiens	13-15
9616166-9	1998	Our study suggests that the decrease in Tf-Fe uptake by R cells is caused by a combination of enhanced iron efflux from cells and decreased TfR-mediated iron transport into cells.	Iron	43-45	transferrin receptor	Homo sapiens	140-143
34145629-3	2021	The SA-Fe, with plane-symmetric Fe-4N coordination, and Fe2 N, with triangular pyramidal Fe-3N coordination, in this well-designed configuration exhibit synergistic adsorption of polysulfides and catalytic selectivity for Li2 Sn lithiation and Li2 S delithiation, respectively.	Iron	7-9	ATP binding cassette subfamily A member 12	Homo sapiens	222-225
34145629-3	2021	The SA-Fe, with plane-symmetric Fe-4N coordination, and Fe2 N, with triangular pyramidal Fe-3N coordination, in this well-designed configuration exhibit synergistic adsorption of polysulfides and catalytic selectivity for Li2 Sn lithiation and Li2 S delithiation, respectively.	Iron	7-9	ATP binding cassette subfamily A member 12	Homo sapiens	244-247
9616166-9	1998	Our study suggests that the decrease in Tf-Fe uptake by R cells is caused by a combination of enhanced iron efflux from cells and decreased TfR-mediated iron transport into cells.	Iron	153-157	transferrin receptor	Homo sapiens	140-143
9616166-10	1998	Furthermore, because TfR-dependent and -independent iron uptake is decreased in R cells, both uptake systems may be controlled at some level by similar regulatory signal(s).	Iron	52-56	transferrin receptor	Homo sapiens	21-24
34154323-0	2021	Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a (3Fe-4S) to a (4Fe-4S) Cluster in Dph1-Dph2.	Iron	62-66	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	121-125
34154323-5	2021	Remarkably, the small iron-containing protein Dph3 donates one Fe atom to convert the (3Fe-4S) cluster in Dph1-Dph2 to a functional (4Fe-4S) cluster during the radical-SAM enzyme catalytic cycle.	Iron	22-26	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	106-110
9611262-5	1998	YIpDCE1 has been used to create strains simultaneously overexpressing the permease (FTR1) and oxidase (FET3) components of the yeast high-affinity iron uptake system.	Iron	147-151	ferroxidase FET3	Saccharomyces cerevisiae S288C	103-107
34154323-5	2021	Remarkably, the small iron-containing protein Dph3 donates one Fe atom to convert the (3Fe-4S) cluster in Dph1-Dph2 to a functional (4Fe-4S) cluster during the radical-SAM enzyme catalytic cycle.	Iron	63-65	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	106-110
34133926-1	2021	Heme is an iron-containing porphyrin of vital importance for cell energetic metabolism.	Iron	11-15	heme	None	0-4
9693743-14	1998	Conserved histidine residues in the CcsA and Ccs1 may serve as ligands to the heme iron.	Iron	83-87	copper chaperone CCS1	Saccharomyces cerevisiae S288C	45-49
34467346-3	2021	Inspired by the natural dinitrosyl iron unit (DNIU) (Fe(NO)2), in this study, a reversible and dynamic interaction between the biomimetic ((NO)2Fe(mu-SCH2CH2OH)2Fe(NO)2) (DNIC-1) and serum albumin (or gastrointestinal mucin) was explored to discover endogenous proteins as a vehicle for an oral delivery of NO to the brain after an oral administration of DNIC-1.	Iron	35-39	albumin	Mus musculus	183-196
9642100-2	1998	Mutations in nramp2 have been shown to be associated with microcytic anemia in mk/mk mice and defective iron transport in Belgrade rats.	Iron	104-108	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	13-19
33905372-3	2021	Since endothelial deficiency of iron-sulfur (Fe-S) clusters is pathogenic in PH, we hypothesized that a Fe-S biogenesis protein, frataxin (FXN), controls endothelial senescence.	Iron	45-49	frataxin	Homo sapiens	129-137
33905372-3	2021	Since endothelial deficiency of iron-sulfur (Fe-S) clusters is pathogenic in PH, we hypothesized that a Fe-S biogenesis protein, frataxin (FXN), controls endothelial senescence.	Iron	45-49	frataxin	Homo sapiens	139-142
9633518-11	1998	Downmodulation of surface TfR may thus represent the physiological control mechanism for reducing iron uptake in diverse pathological conditions including hypoxia-reperfusion injury, acquired immunodeficiency syndrome, and aging.	Iron	98-102	transferrin receptor	Homo sapiens	26-29
33905372-3	2021	Since endothelial deficiency of iron-sulfur (Fe-S) clusters is pathogenic in PH, we hypothesized that a Fe-S biogenesis protein, frataxin (FXN), controls endothelial senescence.	Iron	104-106	frataxin	Homo sapiens	129-137
33905372-3	2021	Since endothelial deficiency of iron-sulfur (Fe-S) clusters is pathogenic in PH, we hypothesized that a Fe-S biogenesis protein, frataxin (FXN), controls endothelial senescence.	Iron	104-106	frataxin	Homo sapiens	139-142
34072813-0	2021	Prevalence and Factors Associated with Iron Deficiency and Anemia among Residents of Urban Areas of Sao Paulo, Brazil.	Iron	39-43	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	100-103
34071287-3	2021	In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms.	Iron	27-31	transferrin receptor	Rattus norvegicus	53-75
34071287-3	2021	In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms.	Iron	27-31	transferrin receptor	Rattus norvegicus	77-81
34071287-3	2021	In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms.	Iron	112-116	transferrin receptor	Rattus norvegicus	53-75
34071287-3	2021	In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms.	Iron	112-116	transferrin receptor	Rattus norvegicus	77-81
34108960-0	2021	Regulation of Th1 T Cell Differentiation by Iron via Upregulation of T Cell Immunoglobulin and Mucin Containing Protein-3 (TIM-3).	Iron	44-48	hepatitis A virus cellular receptor 2	Mus musculus	123-128
34108960-5	2021	This effect could be traced back to iron-mediated induction of the negative immune checkpoint regulator T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), expressed on the surface of this T cell subset.	Iron	36-40	hepatitis A virus cellular receptor 2	Mus musculus	165-170
34108960-6	2021	In vitro experiments demonstrated that iron supplementation specifically upregulated mRNA and protein expression of TIM-3 in naive Th cells in a dose-depdendent manner and hindered priming of those T cells towards Th1 differentiation.	Iron	39-43	hepatitis A virus cellular receptor 2	Mus musculus	116-121
34108960-7	2021	Importantly, administration of TIM-3 blocking antibodies to iron-loaded mice infected with S. Typhimurium virtually restored Th1 cell differentiation and significantly improved bacterial control.	Iron	60-64	hepatitis A virus cellular receptor 2	Mus musculus	31-36
34064225-3	2021	A canonical IRE is a mRNA structure that interacts with the iron regulatory proteins (IRP1 and IRP2) to post-transcriptionally regulate the expression of proteins related to iron metabolism.	Iron	60-64	aconitase 1	Homo sapiens	86-90
34064225-3	2021	A canonical IRE is a mRNA structure that interacts with the iron regulatory proteins (IRP1 and IRP2) to post-transcriptionally regulate the expression of proteins related to iron metabolism.	Iron	174-178	aconitase 1	Homo sapiens	86-90
34063414-0	2021	Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.	Iron	107-111	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	62-66
34063414-0	2021	Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.	Iron	151-155	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	62-66
34063414-1	2021	Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1).	Iron	11-15	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	53-57
34063414-1	2021	Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1).	Iron	38-42	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	53-57
34063414-4	2021	High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import.	Iron	19-23	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	94-98
34063414-4	2021	High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import.	Iron	54-58	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	94-98
34064680-0	2021	Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia.	Iron	40-44	lipocalin 2	Mus musculus	9-20
34064680-2	2021	Lipocalin-2 (LCN2) is an iron-binding protein that has been associated with skeletal muscle regeneration, but details regarding its role in obese sarcopenia remain unclear.	Iron	25-29	lipocalin 2	Mus musculus	0-11
34064680-2	2021	Lipocalin-2 (LCN2) is an iron-binding protein that has been associated with skeletal muscle regeneration, but details regarding its role in obese sarcopenia remain unclear.	Iron	25-29	lipocalin 2	Mus musculus	13-17
34136159-12	2021	Moreover, lower knowledge of iron-based food sources (beta = -1.015, p = .020) and iron-rich foods (beta = -2.188, p = .015) was inversely associated with beef intake.	Iron	29-33	ATPase H+ transporting V0 subunit a1	Gallus gallus	54-63
34927885-6	2021	For OER, (Fe,Co)-SA/CS attained its anodic current density of 10 mA cm-2 at an overpotential of 360 mV.	Iron	10-12	citrate synthase	Homo sapiens	20-22
34927885-7	2021	Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS.	Iron	59-61	citrate synthase	Homo sapiens	69-71
34927885-7	2021	Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS.	Iron	59-61	citrate synthase	Homo sapiens	186-188
34927885-7	2021	Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS.	Iron	176-178	citrate synthase	Homo sapiens	69-71
34927885-7	2021	Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS.	Iron	176-178	citrate synthase	Homo sapiens	186-188
34927885-8	2021	(Fe,Co)-SA/CS evidenced desirable specific capacity and cyclic stability than Pt/C-RuO2 mixture when utilized as an air cathode in a homemade Zinc-air battery.	Iron	1-3	citrate synthase	Homo sapiens	11-13
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	215-217	DNA polymerase iota	Homo sapiens	112-116
35405246-5	2022	The spatial distribution of Mn > 400 mug/L and Fe > 0.3 mg/L was compared and contrasted with that of the critical geogenic contaminant arsenic (As), confirming that high Fe concentrations are often associated with high As concentrations, whereas areas of high concentrations of Mn and As are frequently found adjacent to each other.	Iron	47-49	homeostatic iron regulator	Homo sapiens	166-173
35239084-3	2022	METHODS: We determined the relationship between maternal iron and vitamin A status at delivery using several biomarkers (ferritin, soluble transferrin receptor (sTFR), body iron stores (BIS), hemoglobin and retinol binding protein (RBP)) and birth outcomes (body weight, Z-scores, head circumference, small-for-gestational-age and preterm birth) in rural Uganda.	Iron	57-61	transferrin receptor	Homo sapiens	139-159
35445268-9	2022	In addition, our split-root culture-based analysis provides evidence that the IMA3/FEP1-MYB10/72 pathway mediates long-distance signaling in iron homeostasis through the regulation of coumarin biosynthesis.	Iron	141-145	myb domain protein 10	Arabidopsis thaliana	88-96
35567291-0	2022	MIF/SCL3A2 depletion inhibits the proliferation and metastasis of colorectal cancer cells via the AKT/GSK-3beta pathway and cell iron death.	Iron	129-133	macrophage migration inhibitory factor	Homo sapiens	0-3
35567291-10	2022	In addition, knockdown of MIF and SLC3A2 promoted iron death in SW480 and SW620 cells.	Iron	50-54	macrophage migration inhibitory factor	Homo sapiens	26-29
35229270-0	2022	Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes.	Iron	63-67	protein phosphatase 1, regulatory subunit 3A	Mus musculus	12-15
35229270-7	2022	In our study, we established a chronic PD mouse model by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine combined with probenecid and explored the effect of Rg1 on the oxidative stress and brain iron homeostasis.	Iron	195-199	protein phosphatase 1, regulatory subunit 3A	Mus musculus	157-160
35229270-9	2022	In addition, Rg1 maintained the iron-regulated protein homeostasis by increasing the expression of ferritin heavy chain and decreasing ferritin light chain in oligodendrocytes, especially the mature oligodendrocytes (OLs).	Iron	32-36	protein phosphatase 1, regulatory subunit 3A	Mus musculus	13-16
35229270-11	2022	In conclusion, Rg1 could play a neuroprotective role through remitting the iron-regulated protein dyshomeostasis by ferritin and against lipid peroxidation stress in oligodendrocytes.	Iron	75-79	protein phosphatase 1, regulatory subunit 3A	Mus musculus	15-18
35618957-3	2022	The second transferrin receptor, an iron sensor both in the liver and in erythroid cells modulates erythropoietin sensitivity and is a further link between hepcidin and erythropoiesis.	Iron	36-40	transferrin receptor	Homo sapiens	11-31
35623525-1	2022	The Fundao dam failure, the worst environmental disaster in Brazilian history, launched 50 million m3 of iron ore tailings mud through the Doce River, reaching the Atlantic Ocean.	Iron	105-109	adaptor related protein complex 5 subunit mu 1	Homo sapiens	123-126
35580198-2	2022	We report here that simple Fe 2+ ions, such as those that are bioavailable in the labile iron pool (LIP), react with thionitrite (SNO - ) and perthionitrite (SSNO - ) to yield the dinitrosyl iron complex (Fe(NO) 2 (S 5 )) - .	Iron	27-29	strawberry notch homolog 1	Homo sapiens	130-133
9558341-5	1998	Purified Scr2, but not Scr1, possesses spectral properties which indicate the presence of an iron-sulfur center.	Iron	93-97	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	9-13
35580198-2	2022	We report here that simple Fe 2+ ions, such as those that are bioavailable in the labile iron pool (LIP), react with thionitrite (SNO - ) and perthionitrite (SSNO - ) to yield the dinitrosyl iron complex (Fe(NO) 2 (S 5 )) - .	Iron	89-93	strawberry notch homolog 1	Homo sapiens	130-133
35580198-2	2022	We report here that simple Fe 2+ ions, such as those that are bioavailable in the labile iron pool (LIP), react with thionitrite (SNO - ) and perthionitrite (SSNO - ) to yield the dinitrosyl iron complex (Fe(NO) 2 (S 5 )) - .	Iron	191-195	strawberry notch homolog 1	Homo sapiens	130-133
35602900-3	2022	Transferrin receptor 1(TFR1) expression is associated with intracellular iron overload in macrophages.	Iron	73-77	transferrin receptor	Homo sapiens	23-27
35631204-10	2022	Additionally, decreased activities of glutathione peroxidase and catalase, and increased cleaved-caspase 8 and caspase 3 expression, were found in the iron-deficient rats.	Iron	151-155	caspase 3	Rattus norvegicus	111-120
9606982-2	1998	We show in the current study that receptor expression and regulation can be visualized by NMR imaging, when the receptor is probed with a sterically protected iron containing magnetic hTfR probe.	Iron	159-163	transferrin receptor	Homo sapiens	184-188
35630878-7	2022	Additionally, genes encoding mZip14 metal transporter, enhancing the iron transport, were inserted into the cells via lentiviral transduction.	Iron	69-73	solute carrier family 39 (zinc transporter), member 14	Mus musculus	29-35
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	cytochrome c oxidase II, mitochondrial	Mus musculus	133-137
35525219-7	2022	Mechanistically, CdTe QDs-provoked decrease of nuclear factor erythroid 2-related factor 2 (NRF2) elicited phosphorylation of extracellular regulated protein kinases1/2 (ERK1/2) and then activated ferritinophagy, which made ferritin heavy chain 1 (FTH1) degraded in lysosome and proteasome to release free iron ions to initiate ferroptosis in macrophages.	Iron	306-310	mitogen-activated protein kinase 3	Mus musculus	170-176
9606982-3	1998	We were able to demonstrate that the novel receptor probe was an iron source that could enter the cells via the hTfR but did not play an immediate role in iron downregulation of hTfR within incubation times tested.	Iron	65-69	transferrin receptor	Homo sapiens	112-116
9531620-0	1998	Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice.	Iron	21-25	beta-2 microglobulin	Mus musculus	111-130
35202704-2	2022	Retinal iron overload has been reported in several mouse disease models with systemic or neural retina-specific knockout (KO) of homologous ferroxidases ceruloplasmin (Cp) and hephaestin (Heph).	Iron	8-12	hephaestin	Mus musculus	176-186
35202704-2	2022	Retinal iron overload has been reported in several mouse disease models with systemic or neural retina-specific knockout (KO) of homologous ferroxidases ceruloplasmin (Cp) and hephaestin (Heph).	Iron	8-12	hephaestin	Mus musculus	188-192
35202704-3	2022	Cp and Heph can potentiate ferroportin (Fpn) mediated cellular iron export.	Iron	63-67	hephaestin	Mus musculus	7-11
9531620-2	1998	Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (beta2m-/-) mice, that fail to express MHC class I products, develop iron overload.	Iron	190-194	beta-2 microglobulin	Mus musculus	92-111
9531620-2	1998	Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (beta2m-/-) mice, that fail to express MHC class I products, develop iron overload.	Iron	190-194	beta-2 microglobulin	Mus musculus	122-132
9531620-9	1998	Furthermore, the beta2m-/- mice manifested an impaired capacity to downmodulate iron absorption when dietary or parenterally iron-loaded.	Iron	80-84	beta-2 microglobulin	Mus musculus	17-23
35418692-5	2022	Mechanistically, MT-2 could dramatically up-regulate the expression of nuclear receptor NR4A3 via iron metabolism in PCa cells.	Iron	98-102	transmembrane serine protease 6	Mus musculus	17-21
9531620-9	1998	Furthermore, the beta2m-/- mice manifested an impaired capacity to downmodulate iron absorption when dietary or parenterally iron-loaded.	Iron	125-129	beta-2 microglobulin	Mus musculus	17-23
35418692-5	2022	Mechanistically, MT-2 could dramatically up-regulate the expression of nuclear receptor NR4A3 via iron metabolism in PCa cells.	Iron	98-102	nuclear receptor subfamily 4, group A, member 3	Mus musculus	88-93
9531620-10	1998	The expression of the defect in iron absorption in the beta2m-/- mice is quantitative, with iron absorption being excessively high for the size of body iron stores.	Iron	32-36	beta-2 microglobulin	Mus musculus	55-64
9531620-10	1998	The expression of the defect in iron absorption in the beta2m-/- mice is quantitative, with iron absorption being excessively high for the size of body iron stores.	Iron	92-96	beta-2 microglobulin	Mus musculus	55-64
9531620-10	1998	The expression of the defect in iron absorption in the beta2m-/- mice is quantitative, with iron absorption being excessively high for the size of body iron stores.	Iron	92-96	beta-2 microglobulin	Mus musculus	55-64
9531620-11	1998	The higher iron absorption capacity in the beta2m-/- mice may involve the initial step of ferric mucosal uptake and the subsequent step of mucosal transfer of iron to the plasma.	Iron	11-15	beta-2 microglobulin	Mus musculus	43-49
35490179-4	2022	Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the cytoplasm, de-polyubiquitylates, and stabilizes IRP2 protein in an iron-independent manner.	Iron	190-194	OTU domain containing 3	Mus musculus	16-21
9510559-0	1998	Major histocompatibility complex class I associations in iron overload: evidence for a new link between the HFE H63D mutation, HLA-A29, and non-classical forms of hemochromatosis.	Iron	57-61	homeostatic iron regulator	Homo sapiens	108-111
35490179-4	2022	Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the cytoplasm, de-polyubiquitylates, and stabilizes IRP2 protein in an iron-independent manner.	Iron	190-194	OTU domain containing 3	Mus musculus	23-54
35490179-5	2022	Depletion of OTUD3 results in a disorder of iron metabolism.	Iron	44-48	OTU domain containing 3	Mus musculus	13-18
35490179-6	2022	OTUD3 knockout mice display nigral iron accumulation, motor deficits, and nigrostriatal dopaminergic neurodegeneration, which resembles the pathology of PD.	Iron	35-39	OTU domain containing 3	Mus musculus	0-5
9510559-1	1998	The present study is an analysis of the frequencies of HFE mutations in patients with different forms of iron overload compared with the frequencies found in healthy subjects from the same region.	Iron	105-109	homeostatic iron regulator	Homo sapiens	55-58
35470541-0	2022	Fe-doped MOF-derived N-rich porous carbon nanoframe for H2 S cataluminescence sensing.	Iron	0-2	lysine acetyltransferase 8	Homo sapiens	9-12
9537361-0	1998	Characterization of the cvaA and cvi promoters of the colicin V export system: iron-dependent transcription of cvaA is modulated by downstream sequences.	Iron	79-83	Colicin V	Escherichia coli	54-63
35470541-2	2022	In this work, Fe-doped MOF-derived N-rich porous carbon nanoframe was successfully fabricated by pyrolysis of Fe-doped ZIF-8 in an Ar atmosphere at a temperature of 900  C, and used for H2 S cataluminescence sensing.	Iron	14-16	lysine acetyltransferase 8	Homo sapiens	23-26
9521641-5	1998	At the time of AOM injection, colon Fe concentrations were one- and threefold higher for MHFe and HFe rats, respectively, than for AFe rats.	Iron	36-38	homeostatic iron regulator	Rattus norvegicus	90-93
35333330-1	2022	AlkB homologue 5 (ALKBH5) is a ferrous iron and 2-oxoglutarate dependent oxygenase that demethylates RNA N6-methyladenosine (m6A), a post-transcriptional RNA modification with an emerging set of regulatory roles.	Iron	39-43	alkB homolog 5, RNA demethylase	Homo sapiens	0-16
35333330-1	2022	AlkB homologue 5 (ALKBH5) is a ferrous iron and 2-oxoglutarate dependent oxygenase that demethylates RNA N6-methyladenosine (m6A), a post-transcriptional RNA modification with an emerging set of regulatory roles.	Iron	39-43	alkB homolog 5, RNA demethylase	Homo sapiens	18-24
35445799-6	2022	Interactions were observed between manganese, cadmium, and lead for ferritin and the transferrin receptor, where iron status tended to be worse at higher concentrations of all metals.	Iron	113-117	transferrin receptor	Homo sapiens	85-105
9520490-2	1998	The iron requirement is due to a failure to load Cu2+ onto a component of the iron uptake system, Fet3.	Iron	4-8	ferroxidase FET3	Saccharomyces cerevisiae S288C	98-102
35413222-0	2022	Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice.	Iron	50-54	endothelin receptor type A	Mus musculus	0-21
35413222-2	2022	Endothelin A receptor (ETA) antagonism prevents this iron accumulation phenotype and reduces renal iron deposition in proximal tubules of SCD mice.	Iron	53-57	endothelin receptor type A	Mus musculus	0-21
35413222-2	2022	Endothelin A receptor (ETA) antagonism prevents this iron accumulation phenotype and reduces renal iron deposition in proximal tubules of SCD mice.	Iron	53-57	endothelin receptor type A	Mus musculus	23-26
9520490-2	1998	The iron requirement is due to a failure to load Cu2+ onto a component of the iron uptake system, Fet3.	Iron	78-82	ferroxidase FET3	Saccharomyces cerevisiae S288C	98-102
35413222-2	2022	Endothelin A receptor (ETA) antagonism prevents this iron accumulation phenotype and reduces renal iron deposition in proximal tubules of SCD mice.	Iron	99-103	endothelin receptor type A	Mus musculus	0-21
9551088-3	1998	The HSE-binding activity of HSF1 was induced by a number of chemical stresses including cadmium, aluminum, iron, mercury, arsenite, ethanol, methanol, and salicylate.	Iron	107-111	heat shock factor protein	Xenopus laevis	28-32
35413222-2	2022	Endothelin A receptor (ETA) antagonism prevents this iron accumulation phenotype and reduces renal iron deposition in proximal tubules of SCD mice.	Iron	99-103	endothelin receptor type A	Mus musculus	23-26
9546033-11	1998	CONCLUSIONS: The iron and copper uptake processes in yeast intersect because the FET3 gene encodes a multicopper oxidase that is required for iron transport.	Iron	17-21	ferroxidase FET3	Saccharomyces cerevisiae S288C	81-85
35344334-4	2022	The PF6- counteranion is used for the phosphidation of Fe.	Iron	55-57	sperm associated antigen 17	Homo sapiens	4-7
9546033-11	1998	CONCLUSIONS: The iron and copper uptake processes in yeast intersect because the FET3 gene encodes a multicopper oxidase that is required for iron transport.	Iron	142-146	ferroxidase FET3	Saccharomyces cerevisiae S288C	81-85
35247112-8	2022	Notably, LPS promoted ferroptosis through enhancing GSH depletion and the productions of MDA and iron, which was attenuated by MLK3 knockdown.	Iron	97-101	mitogen-activated protein kinase kinase kinase 11	Mus musculus	127-131
9468479-0	1998	Identification of histidine 45 as the axial heme iron ligand of heme oxygenase-2.	Iron	49-53	heme oxygenase 2	Homo sapiens	64-80
35182697-8	2022	The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4.	Iron	111-115	transferrin receptor	Rattus norvegicus	166-170
35182697-8	2022	The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4.	Iron	111-115	solute carrier family 7 member 11	Rattus norvegicus	262-295
35182697-8	2022	The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4.	Iron	111-115	solute carrier family 7 member 11	Rattus norvegicus	297-304
9521555-5	1998	After treatment of K562 cells with sodium butyrate, the expression of transferrin receptor (TfR) increased initially, followed by an increase in the levels of both total iron and Hb as well as the ALAS activity.	Iron	170-174	transferrin receptor	Homo sapiens	70-90
35182697-8	2022	The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4.	Iron	111-115	glutathione peroxidase 4	Rattus norvegicus	330-334
9521555-5	1998	After treatment of K562 cells with sodium butyrate, the expression of transferrin receptor (TfR) increased initially, followed by an increase in the levels of both total iron and Hb as well as the ALAS activity.	Iron	170-174	transferrin receptor	Homo sapiens	92-95
9521555-9	1998	These results suggest that Hb synthesis is controlled by TfR expression, and that the ALA synthesis is suppressed by iron released from heme and/or Hb due to lowered expression of TfR.	Iron	117-121	transferrin receptor	Homo sapiens	180-183
35131600-4	2022	Peroxisome proliferator-activated receptor gamma (PPARgamma) transcribed Ltf and the lack of neutrophilic Ltf transcription and secretion exacerbated neuronal ferroptosis by accumulating intraneuronal iron.	Iron	201-205	peroxisome proliferator activated receptor gamma	Mus musculus	0-48
9520858-3	1998	Two mutations (C282Y and H63D) in the novel major histocompatibility complex (MHC) class 1 gene HFE were found in most patients with hereditary hemochromatosis causing high iron stores.	Iron	173-177	homeostatic iron regulator	Homo sapiens	96-99
35131600-4	2022	Peroxisome proliferator-activated receptor gamma (PPARgamma) transcribed Ltf and the lack of neutrophilic Ltf transcription and secretion exacerbated neuronal ferroptosis by accumulating intraneuronal iron.	Iron	201-205	peroxisome proliferator activated receptor gamma	Mus musculus	50-59
9446612-11	1998	Taken together, these results elucidate molecular mechanisms involved in the transcriptional regulation of a pivotal gene in iron metabolism and provide insights into the contribution of the Sp1 family to the activation of AP1-dependent enhancers.	Iron	125-129	jun proto-oncogene	Mus musculus	223-226
35149342-5	2022	Mechanistically, extracellular vesicles (EVs) derived from PKM2-activated T lymphocytes elevated macrophage iron accumulation, lipid peroxidation, and migration in vitro, while macrophages treated with EVs from PKM2-null T lymphocytes or pretreated with the lipid peroxidation inhibitors ferrostatin-1 (Fer-1), liproxstatin-1 (Lip-1), or the iron chelating agent deferoxamine mesylate (DFOM) reversed these effects.	Iron	108-112	pyruvate kinase, muscle	Mus musculus	59-63
35149342-5	2022	Mechanistically, extracellular vesicles (EVs) derived from PKM2-activated T lymphocytes elevated macrophage iron accumulation, lipid peroxidation, and migration in vitro, while macrophages treated with EVs from PKM2-null T lymphocytes or pretreated with the lipid peroxidation inhibitors ferrostatin-1 (Fer-1), liproxstatin-1 (Lip-1), or the iron chelating agent deferoxamine mesylate (DFOM) reversed these effects.	Iron	342-346	pyruvate kinase, muscle	Mus musculus	59-63
35344660-4	2022	Here, we present a computational study on the nucleation pathways of the iron-functionalized mixed-valent hexameric (VV2VIV3O5(mu6-O)(mu2-OCH3)12(FeIIICl)) polyoxovanadate-alkoxide cluster.	Iron	73-77	adaptor related protein complex 1 subunit mu 2	Homo sapiens	134-137
9430733-1	1998	Iron regulatory proteins 1 and 2 (IRP-1, IRP-2) interact with iron-responsive elements (IREs) present in the 5"- or 3"-untranslated regions (UTR) of several mRNAs coding for proteins in iron metabolism.	Iron	62-66	aconitase 1	Homo sapiens	0-32
35402284-7	2022	Furthermore, we revealed that PCAT1 inhibited ferroptosis by activating solute carrier family 7-member 11 (SLC7A11) expression via reducing iron accumulation and subsequent oxidative damage.	Iron	140-144	prostate cancer associated transcript 1	Homo sapiens	30-35
34982827-6	2022	Decreased reductase activity resulted in increased transcripts for iron acquisition proteins DMT1 and Tfrc1 suggesting cells were iron limited.	Iron	67-71	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	93-97
9430733-1	1998	Iron regulatory proteins 1 and 2 (IRP-1, IRP-2) interact with iron-responsive elements (IREs) present in the 5"- or 3"-untranslated regions (UTR) of several mRNAs coding for proteins in iron metabolism.	Iron	62-66	aconitase 1	Homo sapiens	34-39
9430733-1	1998	Iron regulatory proteins 1 and 2 (IRP-1, IRP-2) interact with iron-responsive elements (IREs) present in the 5"- or 3"-untranslated regions (UTR) of several mRNAs coding for proteins in iron metabolism.	Iron	186-190	aconitase 1	Homo sapiens	0-32
35051814-6	2022	The Arrhenius fitting analysis revealed that Cu-Fe@CS had a lower activation energy (Ea) than Cu@CS and Fe@CS, meaning that reaction was easier to occur in Fenten-like system with Cu-Fe@CS.	Iron	104-106	citrate synthase	Homo sapiens	107-109
9430733-1	1998	Iron regulatory proteins 1 and 2 (IRP-1, IRP-2) interact with iron-responsive elements (IREs) present in the 5"- or 3"-untranslated regions (UTR) of several mRNAs coding for proteins in iron metabolism.	Iron	186-190	aconitase 1	Homo sapiens	34-39
9443873-3	1998	Cellular degeneration in FRDA may be caused by mitochondrial dysfunction, possibly due to abnormal iron accumulation, as observed in yeast cells deficient for a frataxin homologue.	Iron	99-103	frataxin	Homo sapiens	161-169
35309058-7	2022	Interestingly, hemoglobin synthesis was not limited by iron supply except in cases with further iron loss, in which concomitantly increased soluble transferrin (Tf) receptor (sTfR) levels were detected.	Iron	55-59	transferrin receptor	Homo sapiens	148-173
14538153-4	1998	Competition for infection sites, or for nutrients (such as carbon, iron) as well as induction of the host plant resistance, have been demonstrated for several pathogens such as Rhizoctonia spp., Fusarium spp.	Iron	67-71	histocompatibility minor 13	Homo sapiens	189-192
35269484-13	2022	Remarkably, iron supplementation rescued the short lifespan of the AMPK knockout mutant and confirmed its anti-aging role through the enhancement of mitochondrial functions.	Iron	12-16	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	67-71
10730863-0	1998	Transferrin receptor expression is controlled differently by transferrin-bound and non-transferrin iron in human cells.	Iron	99-103	transferrin receptor	Homo sapiens	0-20
15348695-3	1998	Fibres of the CRG containing iron and cerium were placed into direct contact with human neutrophils and macrophages in tissue culture for 2.5 and 24 h respectively and the responses analysed by scanning electron microscopy (SEM) and confocal microscopy.	Iron	29-33	chromodomain helicase DNA binding protein 7	Homo sapiens	14-17
35016083-4	2022	A corresponding FE model of the natural hip joint with biphasic AC was created based on the bone geometries exported from the MBD model.	Iron	16-18	hedgehog interacting protein	Homo sapiens	40-43
35038358-4	2022	The rescue effects of dZIP13 OE or Tsf1 RNAi were not exerted through mitochondrial disruption or mitophagy, instead, the iron levels in mitochondira were significantly increased, resulting in enhanced activity of enzymes participating in respiration and increased ATP synthesis.	Iron	122-126	Transferrin 1	Drosophila melanogaster	35-39
35038358-5	2022	Consistently, the rescue effects of dZIP13 OE or Tsf1 RNAi on Pink1 RNAi can be inhibited by decreasing the iron levels in mitochondria through mitoferrin (dmfrn) RNAi.	Iron	108-112	Transferrin 1	Drosophila melanogaster	49-53
9460809-1	1998	The human leukocyte antigen (HLA)-linked iron-loading gene (HFE) associated with the autosomal recessive disorder known as hereditary hemochromatosis occurs in about 10% of subjects of European descent, most of whom are unaffected heterozygotes.	Iron	41-45	homeostatic iron regulator	Homo sapiens	60-63
35175757-2	2022	Herein, we present a detailed analysis of the electronic structure of the pentanuclear bow tie Au/Fe carbonyl cluster (Au{eta2-Fe2(CO)8}2)- together with its two one-electron reversible reductions.	Iron	98-100	DNA polymerase iota	Homo sapiens	122-126
35175757-5	2022	A d10 configuration for the gold center in the compound (Au{eta2-Fe2(CO)8}2)- is confirmed by the LUMO orbital composition, which is mainly localized on the iron carbonyl fragments rather than on a d gold orbital, as expected for a d8 configuration.	Iron	157-161	DNA polymerase iota	Homo sapiens	60-64
9516680-7	1998	In PCT, hepatic UROD is inactivated by a process targeted at its catalytic site, which is iron-dependent, requires a heme precursor, and may be accelerated by induction of cytochrome P450s.	Iron	90-94	uroporphyrinogen decarboxylase	Homo sapiens	16-20
35175757-7	2022	Such a trend is also confirmed by the X-ray structure of the direduced compound (Au{eta1-Fe2(CO)8}{eta2-Fe2(CO)6(mu-CO)2})3-, featuring the cleavage of one Au-Fe bond.	Iron	159-161	DNA polymerase iota	Homo sapiens	99-103
35207588-4	2022	The best mica for life"s origins is the black mica, biotite, because it has a high content of Mg++ and because it has iron in various oxidation states.	Iron	118-122	MHC class I polypeptide-related sequence A	Homo sapiens	9-13
9462220-8	1997	Two of five patients who did not have either of the two described mutations of HFE had early onset iron overload (ages 16 and 24).	Iron	99-103	homeostatic iron regulator	Homo sapiens	79-82
35207588-4	2022	The best mica for life"s origins is the black mica, biotite, because it has a high content of Mg++ and because it has iron in various oxidation states.	Iron	118-122	MHC class I polypeptide-related sequence A	Homo sapiens	46-50
9418291-3	1997	The amino acid sequences at the iron-binding sites and the two N-linked glycosylation sites, and the cysteine residues were consistent with known, conserved vertebrate transferrin cDNA sequences.	Iron	32-36	transferrin-a	Oncorhynchus mykiss	168-179
35135884-6	2022	Here we show that MiNT interacts with voltage-dependent anion channel 1 (VDAC1), a major OMM protein that connects the intermembrane space with the cytosol and participates in regulating the levels of different ions including mitochondrial labile iron (mLI).	Iron	247-251	voltage dependent anion channel 1	Homo sapiens	38-71
35135884-6	2022	Here we show that MiNT interacts with voltage-dependent anion channel 1 (VDAC1), a major OMM protein that connects the intermembrane space with the cytosol and participates in regulating the levels of different ions including mitochondrial labile iron (mLI).	Iron	247-251	voltage dependent anion channel 1	Homo sapiens	73-78
9434348-5	1997	Yeast cells lacking a functional PEP3 or PEP5 gene are hypersensitive to copper and render the normally iron-repressible FET3 gene, encoding a multi-copper Fe(II) oxidase involved in Fe2+ transport, also repressible by exogenous copper ions.	Iron	104-108	ferroxidase FET3	Saccharomyces cerevisiae S288C	121-125
9371823-5	1997	The HFE protein was shown by immunohistochemistry to be expressed in certain epithelial cells throughout the human alimentary tract and to have a unique localization in the cryptal cells of small intestine, where signals to regulate iron absorption are received from the body.	Iron	233-237	homeostatic iron regulator	Homo sapiens	4-7
9371823-6	1997	In the studies presented here, we demonstrate by immunohistochemistry that the HFE protein is expressed in human placenta in the apical plasma membrane of the syncytiotrophoblasts, where the transferrin-bound iron is normally transported to the fetus via receptor-mediated endocytosis.	Iron	209-213	homeostatic iron regulator	Homo sapiens	79-82
9371823-9	1997	These studies place the normal HFE protein at the site of contact with the maternal circulation where its association with transferrin receptor raises the possibility that the HFE protein plays some role in determining maternal/fetal iron homeostasis.	Iron	234-238	homeostatic iron regulator	Homo sapiens	31-34
9371823-9	1997	These studies place the normal HFE protein at the site of contact with the maternal circulation where its association with transferrin receptor raises the possibility that the HFE protein plays some role in determining maternal/fetal iron homeostasis.	Iron	234-238	transferrin receptor	Homo sapiens	123-143
9371823-9	1997	These studies place the normal HFE protein at the site of contact with the maternal circulation where its association with transferrin receptor raises the possibility that the HFE protein plays some role in determining maternal/fetal iron homeostasis.	Iron	234-238	homeostatic iron regulator	Homo sapiens	176-179
9371823-10	1997	These findings also raise the question of whether mutations in the HFE gene can disrupt this association and thereby contribute to some forms of neonatal iron overload.	Iron	154-158	homeostatic iron regulator	Homo sapiens	67-70
9326673-3	1997	Exposure of Xenopus oocytes to an extracellular solution containing FeSO4 (25-100 microM) and ascorbic acid (50-200 microM) (Fe/Asc) increased both malondialdehyde content and 2",7"-dichlorofluorescin fluorescence, two indexes of ROS production.	Iron	68-70	PYD and CARD domain containing L homeolog	Xenopus laevis	128-131
9365048-0	1997	Unidirectional upregulation of the synthesis of the major iron proteins, transferrin-receptor and ferritin, in HepG2 cells by the acute-phase protein alpha1-antitrypsin.	Iron	58-62	transferrin receptor	Homo sapiens	73-93
9365048-7	1997	To determine iron regulatory protein binding activity to iron responsive elements we used gel retardation assays and Northern blot analysis was carried out to investigate transferrin receptor and ferritin mRNA expression.	Iron	13-17	transferrin receptor	Homo sapiens	171-191
9365048-7	1997	To determine iron regulatory protein binding activity to iron responsive elements we used gel retardation assays and Northern blot analysis was carried out to investigate transferrin receptor and ferritin mRNA expression.	Iron	57-61	transferrin receptor	Homo sapiens	171-191
9326946-6	1997	The function of the protein is unknown, but an increased iron content has been reported in hearts of FRDA patients and in mitochondria of yeast strains carrying a deleted frataxin gene counterpart (YFH1), suggesting that frataxin plays a major role in regulating mitochondrial iron transport.	Iron	57-61	frataxin	Homo sapiens	221-229
9312270-4	1997	To test this, we studied NOHA oxidation under single-turnover conditions using neuronal NOS (nNOS), whose heme iron reduction requires bound calmodulin.	Iron	111-115	nitric oxide synthase 1	Homo sapiens	79-91
9312270-4	1997	To test this, we studied NOHA oxidation under single-turnover conditions using neuronal NOS (nNOS), whose heme iron reduction requires bound calmodulin.	Iron	111-115	nitric oxide synthase 1	Homo sapiens	93-97
9312270-5	1997	The heme iron in calmodulin-bound nNOS was reduced with excess NADPH under anaerobic conditions, calmodulin was then dissociated from nNOS to prevent subsequent heme iron reduction, NOHA was added, and the reaction initiated by exposure to air.	Iron	9-13	nitric oxide synthase 1	Homo sapiens	34-38
9312270-5	1997	The heme iron in calmodulin-bound nNOS was reduced with excess NADPH under anaerobic conditions, calmodulin was then dissociated from nNOS to prevent subsequent heme iron reduction, NOHA was added, and the reaction initiated by exposure to air.	Iron	9-13	nitric oxide synthase 1	Homo sapiens	134-138
9312270-5	1997	The heme iron in calmodulin-bound nNOS was reduced with excess NADPH under anaerobic conditions, calmodulin was then dissociated from nNOS to prevent subsequent heme iron reduction, NOHA was added, and the reaction initiated by exposure to air.	Iron	166-170	nitric oxide synthase 1	Homo sapiens	34-38
9378401-3	1997	Regulation of ferritin synthesis involves an interaction between an iron regulatory protein (IRP) and part of the ferritin mRNA designated the iron regulatory element (IRE).	Iron	68-72	Wnt family member 2	Homo sapiens	93-96
9303500-1	1997	The liver acquires iron from transferrin by transferrin receptor-mediated (TR) and transferrin receptor-independent pathways (NTR) and from nontransferrin-bound iron (NTB-Fe).	Iron	19-23	neurotensin receptor 1	Homo sapiens	126-129
9303500-2	1997	Iron uptake by the NTR processes involves an iron-carrier mediated step.	Iron	0-4	neurotensin receptor 1	Homo sapiens	19-22
9303500-2	1997	Iron uptake by the NTR processes involves an iron-carrier mediated step.	Iron	45-49	neurotensin receptor 1	Homo sapiens	19-22
9303500-8	1997	However, at a higher Tf-Fe concentration (2.5 micromol/L), when uptake occurs mainly by the NTR-mediated process, there was a 40% reduction in the membrane-bound and intracellular uptake of iron.	Iron	24-26	neurotensin receptor 1	Homo sapiens	92-95
9303500-8	1997	However, at a higher Tf-Fe concentration (2.5 micromol/L), when uptake occurs mainly by the NTR-mediated process, there was a 40% reduction in the membrane-bound and intracellular uptake of iron.	Iron	190-194	neurotensin receptor 1	Homo sapiens	92-95
9303500-9	1997	Iron citrate did not affect the maximum rate (Vmax) of Tf-Fe uptake but the Michaelis-Menten constant (Km) for Tf-Fe uptake by the NTR-mediated process was increased, indicating there was competitive inhibition of Tf-Fe uptake by iron citrate.	Iron	114-116	neurotensin receptor 1	Homo sapiens	131-134
9303500-9	1997	Iron citrate did not affect the maximum rate (Vmax) of Tf-Fe uptake but the Michaelis-Menten constant (Km) for Tf-Fe uptake by the NTR-mediated process was increased, indicating there was competitive inhibition of Tf-Fe uptake by iron citrate.	Iron	114-116	neurotensin receptor 1	Homo sapiens	131-134
9303500-10	1997	These results suggest that the uptake of NTB-Fe and Tf-Fe by the NTR- mediated process occurs by the same cellular pathway, using a common iron-carrier.	Iron	139-143	neurotensin receptor 1	Homo sapiens	65-68
9268306-8	1997	These findings suggest specifically N-nitrosation of glutathione reductase as a likely mechanism of inhibition elicited by dinitrosyl-iron complex and demonstrate in general that structural resemblance of an NO carrier with a natural ligand enhances NO+ transfer to the ligand-binding protein.	Iron	134-138	glutathione-disulfide reductase	Homo sapiens	53-74
9277404-0	1997	Intracellular iron regulates iron absorption and IRP activity in intestinal epithelial (Caco-2) cells.	Iron	14-18	Wnt family member 2	Homo sapiens	49-52
9266189-6	1997	The finding of increased NAG levels in the patients with the increased iron load suggests that kidney lysosomes are a target of iron toxicity.	Iron	71-75	O-GlcNAcase	Homo sapiens	25-28
9266189-6	1997	The finding of increased NAG levels in the patients with the increased iron load suggests that kidney lysosomes are a target of iron toxicity.	Iron	128-132	O-GlcNAcase	Homo sapiens	25-28
9266189-8	1997	CONCLUSION: Iron overload resulted in increased urinary levels of the lysosomal enzyme NAG which has been proposed as an early marker of kidney damage.	Iron	12-16	O-GlcNAcase	Homo sapiens	87-90
9265777-3	1997	The comparative study on the effects of inhibitors such as dithizone, NDGA, phenidone, and beta-mercaptoethanol on the free and immobilized enzyme highlighted the importance of the lipoxygenase--support interaction, concluding that the immobilization process could cause the protection of the iron atom in the enzyme.	Iron	293-297	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	181-193
9195963-5	1997	This mirrors the natural quantitative range of iron-induced adjustment of IRE/IRP1 affinity in mammalian cells.	Iron	47-51	aconitase 1	Homo sapiens	78-82
9260868-3	1997	We demonstrate that ICRF-187 enhanced the binding affinity of iron regulatory protein (IRP), the central regulatory factor for posttranscriptional iron regulation, to RNA stem loop structures, called iron responsive elements (IRE), in THP-1 myelomonocytic as well as K562 erythroleukemic cells.	Iron	62-66	Wnt family member 2	Homo sapiens	87-90
9260868-3	1997	We demonstrate that ICRF-187 enhanced the binding affinity of iron regulatory protein (IRP), the central regulatory factor for posttranscriptional iron regulation, to RNA stem loop structures, called iron responsive elements (IRE), in THP-1 myelomonocytic as well as K562 erythroleukemic cells.	Iron	147-151	Wnt family member 2	Homo sapiens	87-90
9260868-4	1997	Increased IRE/IRP interaction was paralleled by an elevation of transferrin receptor (trf-rec) mRNA levels which, according to the well-established mechanism of posttranscriptional iron regulation, was likely due to stabilisation of trf-rec mRNA by IRP.	Iron	181-185	Wnt family member 2	Homo sapiens	14-17
9260868-4	1997	Increased IRE/IRP interaction was paralleled by an elevation of transferrin receptor (trf-rec) mRNA levels which, according to the well-established mechanism of posttranscriptional iron regulation, was likely due to stabilisation of trf-rec mRNA by IRP.	Iron	181-185	transferrin receptor	Homo sapiens	64-84
9196356-5	1997	A decreased fat intake was associated with an increased sugar intake, but also with increased nutrient densities of thiamin, niacin, folate, vitamin C, magnesium, and iron, reflecting an increased intake of fruit, vegetables, and grains.	Iron	167-171	FAT atypical cadherin 1	Homo sapiens	12-15
35158317-4	2022	Further studies showed that the transcriptional levels of iron-uptake related genes IRT1, FRO2, AHA2, FIT and bHLH38 in mutants were significantly higher than in WT under iron deficiency.	Iron	58-62	ferric reduction oxidase 2	Arabidopsis thaliana	90-94
35204767-6	2022	Interestingly, iron overloading suppressed IRP1 expression, thus downregulating DMT1 and upregulating FPN1 levels in these microglial cells.	Iron	15-19	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	80-84
9092514-2	1997	IRP-1 is a cytoplasmic RNA-binding protein that regulates iron metabolism following its activation by iron deficiency, nitric oxide, and administration of H2O2 or antimycin A, an inhibitor of the respiratory chain (Hentze, M. W., and Kuhn, L. C. (1996) Proc.	Iron	58-62	aconitase 1	Homo sapiens	0-5
35204767-8	2022	Taken together, our data suggest that 6-OHDA can regulate the expression of DMT1 and FPN1 by activating IRP1 and inhibiting hepcidin release, thus leading to abnormal iron sequestration in microglia.	Iron	167-171	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	76-80
34320783-7	2022	In mice, the AAVmediated silencing of Ndfip1 in the murine liver increased the level of hepatic ferroportin and increased circulating iron.	Iron	134-138	Nedd4 family interacting protein 1	Mus musculus	38-44
9083054-2	1997	We now provide evidence that Atx1p helps deliver copper to the copper requiring oxidase Fet3p involved in iron uptake.	Iron	106-110	ferroxidase FET3	Saccharomyces cerevisiae S288C	88-93
9325434-1	1997	Iron uptake by mammalian cells is mediated by the binding of serum Tf to the TfR.	Iron	0-4	transferrin receptor	Homo sapiens	77-80
35014656-4	2022	In order to find an effective way of reducing N2 into NH3, in this work, PC6 monolayers with good electro-optical properties and eight transition metals (V, Cr, Mn, Fe, Co, Ni, Cu, Zn) are chosen to construct PC6-TM3 and PC6-TM4 single cluster catalysts (SCCs), which are proved to have low overpotential, multiple active-sites and superior activity.	Iron	165-167	proprotein convertase subtilisin/kexin type 5	Homo sapiens	73-76
9325434-11	1997	Cellular Fe uptake and storage are coordinately regulated through a feedback control mechanism mediated at the post-transcriptional level by cytoplasmic factors known as IRP1 and IRP2.	Iron	9-11	aconitase 1	Homo sapiens	170-174
9110146-5	1997	The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.)	Iron	15-19	tyrosine aminotransferase	Homo sapiens	40-43
9110146-5	1997	The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.)	Iron	110-114	tyrosine aminotransferase	Homo sapiens	40-43
9110146-10	1997	Iron chelators had also no effect on the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG), but could elevate the GSH:GSSG ratio decreased by Tat protein.	Iron	0-4	tyrosine aminotransferase	Homo sapiens	158-161
35082973-1	2022	Ferroptosis is an iron-dependent form of cell death caused by the inactivation of glutathione peroxidase 4 (GPX4) and accumulation of lipid peroxides.	Iron	18-22	glutathione peroxidase 4	Rattus norvegicus	82-106
9030546-6	1997	Compared with the interaction with P450scc, however, the hydrophobic protein region between the iron-sulfur cluster and the acidic site on the surface of adrenodoxin seems to play an important role for precise complementarity in the tightly associated complex with P45011beta.	Iron	96-100	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	35-42
35082973-1	2022	Ferroptosis is an iron-dependent form of cell death caused by the inactivation of glutathione peroxidase 4 (GPX4) and accumulation of lipid peroxides.	Iron	18-22	glutathione peroxidase 4	Rattus norvegicus	108-112
34499172-3	2022	Here we explored Cd and Fe-associated responses in wildtype Arabidopsis and in a mutant that over-accumulates iron (opt3-2).	Iron	110-114	oligopeptide transporter	Arabidopsis thaliana	116-120
9039823-1	1997	Iron regulatory protein 1 (IRP1) and IRP2 are cytoplasmic RNA binding proteins that coordinate cellular iron homeostasis in mammals.	Iron	104-108	aconitase 1	Rattus norvegicus	0-25
34710708-5	2022	Iron availability to the heart is therefore tightly regulated by (i) the hepcidin/ferroportin axis, which controls dietary iron absorption, storage, and recycling, and (ii) iron regulatory proteins 1 and 2 (IRP1/2) via hypoxia inducible factor 1 (HIF1) pathway.	Iron	0-4	aconitase 1	Homo sapiens	173-205
34710708-5	2022	Iron availability to the heart is therefore tightly regulated by (i) the hepcidin/ferroportin axis, which controls dietary iron absorption, storage, and recycling, and (ii) iron regulatory proteins 1 and 2 (IRP1/2) via hypoxia inducible factor 1 (HIF1) pathway.	Iron	0-4	aconitase 1	Homo sapiens	207-213
9039823-1	1997	Iron regulatory protein 1 (IRP1) and IRP2 are cytoplasmic RNA binding proteins that coordinate cellular iron homeostasis in mammals.	Iron	104-108	aconitase 1	Rattus norvegicus	27-31
35121990-3	2022	Here, we show that ENO1 suppresses iron regulatory protein 1 (IRP1) expression to regulate iron homeostasis and survival of hepatocellular carcinoma (HCC) cells.	Iron	91-95	aconitase 1	Homo sapiens	35-60
35121990-3	2022	Here, we show that ENO1 suppresses iron regulatory protein 1 (IRP1) expression to regulate iron homeostasis and survival of hepatocellular carcinoma (HCC) cells.	Iron	91-95	aconitase 1	Homo sapiens	62-66
35121990-4	2022	Mechanistically, we demonstrate that ENO1, as an RNA-binding protein, recruits CNOT6 to accelerate the messenger RNA decay of IRP1 in cancer cells, leading to inhibition of mitoferrin-1 (Mfrn1) expression and subsequent repression of mitochondrial iron-induced ferroptosis.	Iron	248-252	aconitase 1	Homo sapiens	126-130
9039823-2	1997	We investigated the effect of dietary iron intake on rat liver IRP activity in relation to the abundance of two targets of IRP action, ferritin and mitochondrial aconitase (m-aconitase).	Iron	38-42	caspase 3	Rattus norvegicus	63-66
9039823-2	1997	We investigated the effect of dietary iron intake on rat liver IRP activity in relation to the abundance of two targets of IRP action, ferritin and mitochondrial aconitase (m-aconitase).	Iron	38-42	caspase 3	Rattus norvegicus	123-126
9039823-4	1997	RNA binding activity of IRP1 and IRP2 was enhanced one- to twofold in rats fed 11 or 2 mg iron/kg diet compared with control rats.	Iron	90-94	aconitase 1	Rattus norvegicus	24-28
9039823-10	1997	Our results indicate that (1) liver IRP activity is responsive to a range of dietary iron levels, (2) there appears to be a differential effect of IRPs on ferritin and m-aconitase abundance, and (3) activation of IRPs may contribute to the alterations in energy metabolism in iron deficiency through an impairment of m-aconitase synthesis.	Iron	85-89	caspase 3	Rattus norvegicus	36-39
9523007-7	1997	Jurkat cells, when exposed to iron-saturated lactoferrin in the presence of 10% FCS, gradually exhibited a decrease in the cell volume, cell surface density of CD71 antigen, the nuclear incorporation of [methyl-3H]thymidine, but an increase of the percentage of cell population in the G0/1 phase of the cell cycle.	Iron	30-34	transferrin receptor	Homo sapiens	160-164
9046063-0	1997	Iron deprivation and cancer: a view beginning with studies of monoclonal antibodies against the transferrin receptor.	Iron	0-4	transferrin receptor	Mus musculus	96-116
9032645-1	1997	Hereditary haemochromatosis (HFE) is a recessive genetic disease of iron overload which has been shown by linkage analysis to reside on the short arm of chromosome 6, close to the major histocompatibility complex (MHC).	Iron	68-72	homeostatic iron regulator	Homo sapiens	29-32
8940249-0	1996	Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin D/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells.	Iron	0-4	cyclin dependent kinase 4	Homo sapiens	82-86
8940249-6	1996	Interestingly, Western blot analysis also demonstrated that iron chelation decreased the protein levels of the cyclin D and cdk4 subunits as compared to control and produced a change in retinoblastoma protein phosphorylation.	Iron	60-64	cyclin dependent kinase 4	Homo sapiens	124-128
8944690-5	1996	Iron overload produced a decrease in transferrin receptor (TfR) mRNA in the duodenum, with ferritin mRNA levels unaffected in both the duodenum and ileum.	Iron	0-4	transferrin receptor	Mus musculus	37-57
8944690-5	1996	Iron overload produced a decrease in transferrin receptor (TfR) mRNA in the duodenum, with ferritin mRNA levels unaffected in both the duodenum and ileum.	Iron	0-4	transferrin receptor	Mus musculus	59-62
8902231-16	1996	The association of RBP and TF concentrations with AP in various maternal and conceptus compartments during pregnancy is consistent with the hypothesis that one function of these two proteins may be to protect maternal and fetal tissues from lipid peroxidation that is a possible consequence of iron transport via endometrial secretion of UF.	Iron	294-298	transferrin	Sus scrofa	27-29
8920884-7	1996	We conclude that (a) iron metabolism is defective in the gut mucosa as well as the liver of beta 2m-/- mice; and (b) a beta 2m-dependent gene product is involved in iron homeostasis.	Iron	165-169	beta-2 microglobulin	Mus musculus	92-102
8798695-0	1996	Characterization of the active site iron in tyrosine hydroxylase.	Iron	36-40	tyrosine hydroxylase	Rattus norvegicus	44-64
8798695-4	1996	Purification of recombinant rat tyrosine hydroxylase containing 0.5-0.7 iron atoms/subunit and lacking bound catecholamine has permitted studies of the redox states of the resting enzyme and the enzyme during catalysis.	Iron	72-76	tyrosine hydroxylase	Rattus norvegicus	32-52
14688921-1	1996	The aim of this study was to evaluate the efficacy of an iron prophylactic supplementation program, in three health centers of Santo Andre, in Sao Paulo state.	Iron	57-61	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	143-146
8761454-6	1996	In addition, iron-induced increases in ferritin mRNA abundance were the same as wild-type plants in abi1 and abi2 mutants of A. thaliana, both affected in the abscisic acid response in vegetative tissues.	Iron	13-17	Protein phosphatase 2C family protein	Arabidopsis thaliana	100-104
8761454-6	1996	In addition, iron-induced increases in ferritin mRNA abundance were the same as wild-type plants in abi1 and abi2 mutants of A. thaliana, both affected in the abscisic acid response in vegetative tissues.	Iron	13-17	Protein phosphatase 2C family protein	Arabidopsis thaliana	109-113
8704216-1	1996	Recent studies have indicated that nitric oxide may affect iron metabolism through disruption of the iron-sulfur complex of iron regulatory protein-1, a translational regulator.	Iron	59-63	aconitase 1	Homo sapiens	124-149
8704216-1	1996	Recent studies have indicated that nitric oxide may affect iron metabolism through disruption of the iron-sulfur complex of iron regulatory protein-1, a translational regulator.	Iron	101-105	aconitase 1	Homo sapiens	124-149
8668195-7	1996	This contrasts with the IRP-1 activation pathway by NO and iron depletion, in which NO-releasing drugs or iron chelators need to be present during the entire activation phase.	Iron	59-63	aconitase 1	Homo sapiens	24-29
8668195-7	1996	This contrasts with the IRP-1 activation pathway by NO and iron depletion, in which NO-releasing drugs or iron chelators need to be present during the entire activation phase.	Iron	106-110	aconitase 1	Homo sapiens	24-29
8668195-8	1996	Finally, we demonstrate that biologically synthesized NO regulates the expression of IRE-containing mRNAs in target cells by passive diffusion and that oxidative stress endogenously generated by pharmacological modulation of the mitochondrial respiratory chain activates IRP-1, underscoring the physiological significance of NO and reactive oxygen intermediates as regulators of cellular iron metabolism.	Iron	388-392	aconitase 1	Homo sapiens	271-276
8856799-0	1996	Transferrin modifies surfactant responsiveness in acute respiratory failure: role of iron-free transferrin as an antioxidant.	Iron	85-89	serotransferrin	Oryctolagus cuniculus	95-106
8856799-1	1996	In respiratory failure, transferrin (TF) with variable iron saturation accumulates in the alveolar space.	Iron	55-59	serotransferrin	Oryctolagus cuniculus	24-35
8856799-1	1996	In respiratory failure, transferrin (TF) with variable iron saturation accumulates in the alveolar space.	Iron	55-59	serotransferrin	Oryctolagus cuniculus	37-39
8856799-2	1996	Binding free iron to TF may inhibit metal-catalyzed formation of free radicals.	Iron	13-17	serotransferrin	Oryctolagus cuniculus	21-23
8856799-3	1996	The aim of this study was to evaluate whether the degree of the iron-saturation of TF influences the severity of respiratory failure and surfactant responsiveness.	Iron	64-68	serotransferrin	Oryctolagus cuniculus	83-85
8856799-7	1996	Administration of Iron-free TF significantly decreased the iron saturation of TF in BAL.	Iron	18-22	serotransferrin	Oryctolagus cuniculus	28-30
8856799-7	1996	Administration of Iron-free TF significantly decreased the iron saturation of TF in BAL.	Iron	18-22	serotransferrin	Oryctolagus cuniculus	78-80
8856799-7	1996	Administration of Iron-free TF significantly decreased the iron saturation of TF in BAL.	Iron	59-63	serotransferrin	Oryctolagus cuniculus	28-30
8856799-7	1996	Administration of Iron-free TF significantly decreased the iron saturation of TF in BAL.	Iron	59-63	serotransferrin	Oryctolagus cuniculus	78-80
8856799-9	1996	By contrast, in respiratory failure induced by hyperoxia and BAL, iron-free TF improved the efficacy of exogenous surfactant, but Fe(2+)-TF had no effect.	Iron	66-70	serotransferrin	Oryctolagus cuniculus	76-78
8856799-10	1996	After administration of iron-free TF, surfactant isolated from BAL was more surface-active than surfactant from BAL of the other hyperoxia-treated animals.	Iron	24-28	serotransferrin	Oryctolagus cuniculus	34-36
8679654-1	1996	Rabbit erythroid cells can take up non-transferrin-bound iron by a high-affinity and a low-affinity transport mechanism (Hodgson et al.	Iron	57-61	serotransferrin	Oryctolagus cuniculus	39-50
9280000-0	1996	Iron status of Filipino infants and preschoolers using plasma ferritin and transferrin receptor levels.	Iron	0-4	transferrin receptor	Homo sapiens	75-95
8662626-1	1996	The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis by binding to iron-responsive elements (IREs) in the transferrin receptor and ferritin mRNAs to coordinately regulate transferrin receptor mRNA stability and ferritin mRNA translational efficiency, respectively.	Iron	16-20	Wnt family member 2	Homo sapiens	41-44
8662626-1	1996	The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis by binding to iron-responsive elements (IREs) in the transferrin receptor and ferritin mRNAs to coordinately regulate transferrin receptor mRNA stability and ferritin mRNA translational efficiency, respectively.	Iron	16-20	transferrin receptor	Homo sapiens	126-146
8662626-1	1996	The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis by binding to iron-responsive elements (IREs) in the transferrin receptor and ferritin mRNAs to coordinately regulate transferrin receptor mRNA stability and ferritin mRNA translational efficiency, respectively.	Iron	16-20	transferrin receptor	Homo sapiens	191-211
8662626-1	1996	The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis by binding to iron-responsive elements (IREs) in the transferrin receptor and ferritin mRNAs to coordinately regulate transferrin receptor mRNA stability and ferritin mRNA translational efficiency, respectively.	Iron	56-60	Wnt family member 2	Homo sapiens	16-39
8662626-1	1996	The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis by binding to iron-responsive elements (IREs) in the transferrin receptor and ferritin mRNAs to coordinately regulate transferrin receptor mRNA stability and ferritin mRNA translational efficiency, respectively.	Iron	56-60	Wnt family member 2	Homo sapiens	41-44
8662626-1	1996	The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis by binding to iron-responsive elements (IREs) in the transferrin receptor and ferritin mRNAs to coordinately regulate transferrin receptor mRNA stability and ferritin mRNA translational efficiency, respectively.	Iron	56-60	transferrin receptor	Homo sapiens	126-146
8662626-3	1996	T3 augmented an iron-induced reduction in IRP binding activity to a ferritin IRE in RNA electrophoretic mobility shift assays using cytoplasmic extracts from human liver hepatoma (HepG2) cells.	Iron	16-20	Wnt family member 2	Homo sapiens	42-45
8662626-4	1996	Hepatic IRP binding to the ferritin IRE also diminished after in vivo administration of T3 with iron to rats.	Iron	96-100	caspase 3	Rattus norvegicus	8-11
8619873-3	1996	We here describe the drosophila melanogaster succinate dehydrogenase iron protein (SDH-IP) as a fourth example of an mRNA species being translationally regulated by an IRE, based on iron dependent regulation of SDH-IP translation in vivo by immunoprecipitations and northern blotting in drosophila cell lines.	Iron	69-73	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	83-89
8619873-3	1996	We here describe the drosophila melanogaster succinate dehydrogenase iron protein (SDH-IP) as a fourth example of an mRNA species being translationally regulated by an IRE, based on iron dependent regulation of SDH-IP translation in vivo by immunoprecipitations and northern blotting in drosophila cell lines.	Iron	69-73	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	211-217
8739236-1	1996	Heme oxygenase (HO) isozymes, HO-1 and HO-2 catalyze the cleavage of heme b to form the antioxidant biliverdin IXa, iron and the putative cellular messenger carbon monoxide (CO).	Iron	116-120	heme oxygenase 1	Sus scrofa	30-34
8609896-2	1996	Loss of iron from the alkylated heme results in formation of an N-alkylporphyrin, which is a potent inhibitor of ferrochelatase.	Iron	8-12	ferrochelatase	Gallus gallus	113-127
9372069-5	1996	Speculation about their causes includes disturbed intracellular iron homeostasis involving iron-responsive factors involved in the translational control of ALAS2 and in certain nuclear and mitochondrial genes important for erythroid mitochondrial metabolism.	Iron	64-68	5'-aminolevulinate synthase 2	Homo sapiens	156-161
9372069-5	1996	Speculation about their causes includes disturbed intracellular iron homeostasis involving iron-responsive factors involved in the translational control of ALAS2 and in certain nuclear and mitochondrial genes important for erythroid mitochondrial metabolism.	Iron	91-95	5'-aminolevulinate synthase 2	Homo sapiens	156-161
8599607-0	1996	Effect of lipid peroxidation on transferrin-free iron uptake by rabbit reticulocytes.	Iron	49-53	serotransferrin	Oryctolagus cuniculus	32-43
8608223-5	1996	The finding that EOS47 lacks several of the iron-coordinating amino acids present in all transferrins suggests that it may be impaired in its ability to bind iron.	Iron	44-48	melanotransferrin	Gallus gallus	17-22
8608223-5	1996	The finding that EOS47 lacks several of the iron-coordinating amino acids present in all transferrins suggests that it may be impaired in its ability to bind iron.	Iron	158-162	melanotransferrin	Gallus gallus	17-22
8856975-3	1996	Regulation of expression of proteins of iron uptake (transferrin receptor) and iron sequestration (ferritin) presumably ensures that levels of reactive free iron are not high in cells.	Iron	40-44	transferrin receptor	Homo sapiens	53-73
8856975-6	1996	Iron regulatory protein 1 (IRP1) is a bifunctional protein; in cells that are iron-replete, IRP1 contains an iron-sulfur cluster and functions as cytosolic aconitase.	Iron	78-82	aconitase 1	Homo sapiens	0-25
8856975-6	1996	Iron regulatory protein 1 (IRP1) is a bifunctional protein; in cells that are iron-replete, IRP1 contains an iron-sulfur cluster and functions as cytosolic aconitase.	Iron	78-82	aconitase 1	Homo sapiens	27-31
8856975-6	1996	Iron regulatory protein 1 (IRP1) is a bifunctional protein; in cells that are iron-replete, IRP1 contains an iron-sulfur cluster and functions as cytosolic aconitase.	Iron	78-82	aconitase 1	Homo sapiens	92-96
8856975-6	1996	Iron regulatory protein 1 (IRP1) is a bifunctional protein; in cells that are iron-replete, IRP1 contains an iron-sulfur cluster and functions as cytosolic aconitase.	Iron	109-113	aconitase 1	Homo sapiens	0-25
8856975-6	1996	Iron regulatory protein 1 (IRP1) is a bifunctional protein; in cells that are iron-replete, IRP1 contains an iron-sulfur cluster and functions as cytosolic aconitase.	Iron	109-113	aconitase 1	Homo sapiens	27-31
8856975-6	1996	Iron regulatory protein 1 (IRP1) is a bifunctional protein; in cells that are iron-replete, IRP1 contains an iron-sulfur cluster and functions as cytosolic aconitase.	Iron	109-113	aconitase 1	Homo sapiens	92-96
8856975-7	1996	In cells that are iron-depleted, IRP1 binds stem-loop structures in RNA transcripts known as iron responsive elements (IREs).	Iron	18-22	aconitase 1	Homo sapiens	33-37
8856975-7	1996	In cells that are iron-depleted, IRP1 binds stem-loop structures in RNA transcripts known as iron responsive elements (IREs).	Iron	93-97	aconitase 1	Homo sapiens	33-37
8727377-1	1996	The modulation of cellular iron metabolism depends on the expression of ferritin and transferrin receptor (TfR).	Iron	27-31	transferrin receptor	Homo sapiens	85-105
8727377-1	1996	The modulation of cellular iron metabolism depends on the expression of ferritin and transferrin receptor (TfR).	Iron	27-31	transferrin receptor	Homo sapiens	107-110
8727377-4	1996	In hepatocytes iron is taken up in the form of transferrin and intercellular iron levels are regulated by IRE/IRE-BP interaction.	Iron	15-19	aconitase 1	Homo sapiens	110-116
8727377-4	1996	In hepatocytes iron is taken up in the form of transferrin and intercellular iron levels are regulated by IRE/IRE-BP interaction.	Iron	77-81	aconitase 1	Homo sapiens	110-116
8727377-7	1996	This study revealed that the binding activity of IRE-BP to IRE was increased when HepG2 cells were cultured with an iron-chelating agent, deferoxamine (4.5 microM), and it was decreased when cultured with transferrin (100 micrograms/ml) during both proliferation and differentiational change induced by sodium butyrate.	Iron	116-120	aconitase 1	Homo sapiens	49-55
8727377-9	1996	These findings suggest that IRE/IRE-BP interaction may play an important role in the expression of TfR and cellular iron metabolism during proliferation and differentiational change of HepG2 cells.	Iron	116-120	aconitase 1	Homo sapiens	32-38
8821945-1	1996	Transferrin-binding protein 2 (Tbp2) from Neisseria is an outer membrane-associated extracellular lipoprotein that is involved in iron capture within the infected host.	Iron	130-134	TATA-box binding protein like 2	Homo sapiens	31-35
8821649-1	1996	When grown in vivo, or under iron-restriction in vitro, Neisseria meningitidis expresses a number of iron-regulated outer membrane proteins, including two transferrin-binding proteins (Tbp1 and Tbp2).	Iron	101-105	TATA-box binding protein like 2	Homo sapiens	194-198
8847543-1	1995	All organs including the brain contain iron, and the proteins involved in iron uptake (transferrin and transferrin receptor) and intracellular storage (ferritin).	Iron	74-78	transferrin receptor	Homo sapiens	103-123
7493028-1	1995	The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE).	Iron	31-35	Wnt family member 2	Homo sapiens	153-176
7493028-1	1995	The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE).	Iron	31-35	Wnt family member 2	Homo sapiens	178-181
7493028-1	1995	The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE).	Iron	97-101	Wnt family member 2	Homo sapiens	153-176
7493028-1	1995	The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE).	Iron	97-101	Wnt family member 2	Homo sapiens	178-181
7493028-1	1995	The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE).	Iron	97-101	Wnt family member 2	Homo sapiens	153-176
7493028-1	1995	The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE).	Iron	97-101	Wnt family member 2	Homo sapiens	178-181
7493028-2	1995	This region forms a stem-loop structure and when the supply of iron to the cells is limited, the IRP is bound to IRE and represses ferritin synthesis.	Iron	63-67	Wnt family member 2	Homo sapiens	97-100
7578122-2	1995	Zn2+ blocks NADPH-dependent reduction of heme iron in nNOS and also blocks the calmodulin-dependent superoxide-mediated cytochrome c reductase activity exhibited by nNOS.	Iron	46-50	nitric oxide synthase 1	Homo sapiens	54-58
7578122-5	1995	These spectral changes are consistent with a Zn(2+)-dependent change in the spin-state equilibrium of the heme iron in nNOS.	Iron	111-115	nitric oxide synthase 1	Homo sapiens	119-123
7578122-7	1995	The estimated maximal change in nNOS absorbance at approximately 418 nm caused by the L-arginine-dependent conversion of the ferric heme iron from hexacoordinate low-spin to pentacoordinate high-spin is increased by 50% in the presence of 50 microM Zn2+, which reflects the increased initial amount of low-spin ferric heme iron present.	Iron	137-141	nitric oxide synthase 1	Homo sapiens	32-36
7578122-7	1995	The estimated maximal change in nNOS absorbance at approximately 418 nm caused by the L-arginine-dependent conversion of the ferric heme iron from hexacoordinate low-spin to pentacoordinate high-spin is increased by 50% in the presence of 50 microM Zn2+, which reflects the increased initial amount of low-spin ferric heme iron present.	Iron	323-327	nitric oxide synthase 1	Homo sapiens	32-36
7578122-8	1995	These data indicate that Zn(2+)-dependent inhibition of nNOS activity is due to binding of Zn2+ to the hemoprotein domain in the enzyme and that inhibition is associated with perturbations in the environment of the heme iron that appear to block its ability to mediate oxygen reduction.	Iron	199-203	nitric oxide synthase 1	Homo sapiens	56-60
7479083-5	1995	Our in vivo results suggest that only a very small variation in the affinity of interaction of IRP with IRE can be tolerated in order to maintain iron-dependent regulation of translation.	Iron	146-150	caspase 3	Rattus norvegicus	95-98
8547100-0	1995	Duodenal expression of NF-E2 in mouse models of altered iron metabolism.	Iron	56-60	nuclear factor, erythroid derived 2	Mus musculus	23-28
8547100-1	1995	This study investigated the relationship between duodenal mucosal mRNA levels of the transcription factor, NF-E2, H-ferritin (a putative NF-E2 regulated gene) and iron absorption in mice.	Iron	163-167	nuclear factor, erythroid derived 2	Mus musculus	137-142
8547100-4	1995	Duodenal NF-E2 mRNA levels were generally low and decreased in the hypoxic and iron-deficient groups, both of which exhibited elevated iron absorption as compared to controls.	Iron	79-83	nuclear factor, erythroid derived 2	Mus musculus	9-14
8547100-4	1995	Duodenal NF-E2 mRNA levels were generally low and decreased in the hypoxic and iron-deficient groups, both of which exhibited elevated iron absorption as compared to controls.	Iron	135-139	nuclear factor, erythroid derived 2	Mus musculus	9-14
8547100-5	1995	A modest increase in the NF-E2 mRNA level was seen in the iron-loaded mice, whose iron absorption was decreased.	Iron	58-62	nuclear factor, erythroid derived 2	Mus musculus	25-30
8547100-5	1995	A modest increase in the NF-E2 mRNA level was seen in the iron-loaded mice, whose iron absorption was decreased.	Iron	82-86	nuclear factor, erythroid derived 2	Mus musculus	25-30
8574013-4	1995	Cu/Zn- and Mn-SOD reactivity was detectable in hepatocytes with a heavy and a low iron burden, but Cu/Zn-SOD staining was more intense than that of Mn-SOD in the three groups analysed.	Iron	82-86	superoxide dismutase 2	Homo sapiens	11-17
8574013-6	1995	The findings suggest that the two SOD"s may be differentially expressed in states of hepatic iron overload, and that low expression of the inducible radical scavenger, Mn-SOD, may play a role in chronic iron toxicity.	Iron	93-97	superoxide dismutase 2	Homo sapiens	34-37
8574013-6	1995	The findings suggest that the two SOD"s may be differentially expressed in states of hepatic iron overload, and that low expression of the inducible radical scavenger, Mn-SOD, may play a role in chronic iron toxicity.	Iron	203-207	superoxide dismutase 2	Homo sapiens	168-174
7662974-0	1995	Effects of iron-depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase.	Iron	11-15	cyclin dependent kinase 2	Homo sapiens	166-173
7641199-12	1995	Thus, an iron deprivation treatment protocol with HES-DFO and IgG ATRAS produced both a significant antitumor effect and an increased risk of infection in a murine model system.	Iron	9-13	immunoglobulin heavy variable V1-62	Mus musculus	62-65
7556182-10	1995	The present data suggest that NO-mediated activation of IRP regulates alterations of hepatic iron homeostasis that occur in acute inflammation.	Iron	93-97	caspase 3	Rattus norvegicus	56-59
7652554-3	1995	Electron density distribution of the oxidized bovine cytochrome c oxidase at 2.8 A resolution indicates a dinuclear copper center with an unexpected structure similar to a [2Fe-2S]-type iron-sulfur center.	Iron	186-190	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	53-73
7642638-6	1995	The iron-responsive element-binding protein (IRP-1) exists in three states: bound to mRNA without aconitase activity, free in the cytosol without aconitase activity, and free in the cytosol with aconitase activity.	Iron	4-8	aconitase 1	Homo sapiens	45-50
7642638-8	1995	Enhanced ferritin synthesis with subsequent iron stimulation is due to the altered equilibrium of the free IRP-1.	Iron	44-48	aconitase 1	Homo sapiens	107-112
7796817-6	1995	Both responses are post-transcriptional and result from induction of iron regulatory protein (IRP) binding to iron-responsive elements (IREs) in ferritin and TfR mRNAs.	Iron	69-73	Wnt family member 2	Homo sapiens	94-97
7796817-6	1995	Both responses are post-transcriptional and result from induction of iron regulatory protein (IRP) binding to iron-responsive elements (IREs) in ferritin and TfR mRNAs.	Iron	69-73	transferrin receptor	Homo sapiens	158-161
7796817-10	1995	Whereas the activation of IRP by iron depletion is insensitive to okadaic acid, the rapid induction by H2O2 is blocked by this inhibitor of type I/IIa protein phosphatases.	Iron	33-37	Wnt family member 2	Homo sapiens	26-29
7768617-1	1995	Haemophilus influenzae can acquire heme from hemopexin for use as a source of both essential porphyrin and iron.	Iron	107-111	hemopexin	Homo sapiens	45-54
7768617-2	1995	In classical ligand-binding studies, we observed time-dependent, saturable, and displaceable binding of human 125I-labelled hemopexin to intact cells of H. influenzae type b (Hib) strain 760705 grown in an iron-restricted medium.	Iron	206-210	hemopexin	Homo sapiens	124-133
8527044-1	1995	Transferrin receptor (TR) performs the major function of binding and internalizing its specific iron-loaded ligand, transferrin, and its expression is closely linked to the proliferation status of the cell.	Iron	96-100	transferrin receptor	Rattus norvegicus	0-20
8527044-1	1995	Transferrin receptor (TR) performs the major function of binding and internalizing its specific iron-loaded ligand, transferrin, and its expression is closely linked to the proliferation status of the cell.	Iron	96-100	transferrin receptor	Rattus norvegicus	22-24
8527044-6	1995	The liver of rats fed on high iron diet accumulated iron and the expression of TR was down regulated by intrahepatic iron accumulation.	Iron	30-34	transferrin receptor	Rattus norvegicus	79-81
8527044-8	1995	The strong membranous expression of TR is one of the characteristics of the resistant hepatocyte of hyperplastic lesion and it seems to be related to the inability to accumulate iron in spite of a high iron diet.	Iron	178-182	transferrin receptor	Rattus norvegicus	36-38
8527044-8	1995	The strong membranous expression of TR is one of the characteristics of the resistant hepatocyte of hyperplastic lesion and it seems to be related to the inability to accumulate iron in spite of a high iron diet.	Iron	202-206	transferrin receptor	Rattus norvegicus	36-38
7745438-3	1995	Serum transferrin is largely biosynthesized in the liver, and its established physiological role is the transport of iron to tissue sites and delivery of the metal to the interior of cells that have transferrin receptors on their surfaces.	Iron	117-121	serotransferrin	Oryctolagus cuniculus	6-17
7770514-5	1995	Activated and proliferating cells respond to the demand for intracellular iron by upregulating membrane expression of the transferrin receptor (CD71) which is needed for iron uptake.	Iron	74-78	transferrin receptor	Homo sapiens	122-142
7770514-5	1995	Activated and proliferating cells respond to the demand for intracellular iron by upregulating membrane expression of the transferrin receptor (CD71) which is needed for iron uptake.	Iron	74-78	transferrin receptor	Homo sapiens	144-148
7770514-5	1995	Activated and proliferating cells respond to the demand for intracellular iron by upregulating membrane expression of the transferrin receptor (CD71) which is needed for iron uptake.	Iron	170-174	transferrin receptor	Homo sapiens	122-142
7770514-5	1995	Activated and proliferating cells respond to the demand for intracellular iron by upregulating membrane expression of the transferrin receptor (CD71) which is needed for iron uptake.	Iron	170-174	transferrin receptor	Homo sapiens	144-148
7770514-6	1995	We predicted that activated lymphocytes (CD71+) would preferentially accumulate PpIX because of their lower intracellular iron levels and because of competition for iron between ALA-induced heme production and cellular growth processes.	Iron	122-126	transferrin receptor	Homo sapiens	41-45
7770514-6	1995	We predicted that activated lymphocytes (CD71+) would preferentially accumulate PpIX because of their lower intracellular iron levels and because of competition for iron between ALA-induced heme production and cellular growth processes.	Iron	165-169	transferrin receptor	Homo sapiens	41-45
7711032-3	1995	In this report, the effect of H(+)-ATPase inhibitors on iron mobilization is investigated at pH 6.0 in the presence of 15 microM FCCP in order to dissociate 59Fe(III) from transferrin and eliminate the kinetic effects of acidification by the ATPase.	Iron	56-60	serotransferrin	Oryctolagus cuniculus	172-183
7744060-6	1995	267, 4524-4532] that Fe.ATP bound at the site for ATPB catalyzes the oxidative inactivation of carbamoyl-phosphate synthetase I in a model oxidative system consisting of Fe3+, ascorbate, and O2, and we detected ATP-promoted oxidative cleavage of the enzyme.	Iron	21-23	carbamoyl-phosphate synthase 1	Homo sapiens	95-127
7606879-9	1995	In the responders the TfR levels were higher during iron therapy than in the nonresponders (p &lt; 0.02).	Iron	52-56	transferrin receptor	Homo sapiens	22-25
7585245-6	1995	This prompted a detailed analysis of how iron and NO regulate the RNA-binding activities of IRP and IRPB.	Iron	41-45	Wnt family member 2	Homo sapiens	92-95
7788730-0	1995	[Transferrin receptor and iron deposition pattern in the hepatic lobules of the iron-deficient and iron-overloaded rats].	Iron	80-84	transferrin receptor	Rattus norvegicus	1-21
7788730-0	1995	[Transferrin receptor and iron deposition pattern in the hepatic lobules of the iron-deficient and iron-overloaded rats].	Iron	80-84	transferrin receptor	Rattus norvegicus	1-21
7788730-4	1995	TfR and Tf were mainly distributed in the peripheral part of the lobule (zone 1) in the normal, iron deficient and iron-overloaded rats.	Iron	96-100	transferrin receptor	Rattus norvegicus	0-3
7788730-4	1995	TfR and Tf were mainly distributed in the peripheral part of the lobule (zone 1) in the normal, iron deficient and iron-overloaded rats.	Iron	115-119	transferrin receptor	Rattus norvegicus	0-3
7788730-6	1995	The staining intensity of TfR was strongest in iron-deficiency rat hepatic cells, weakest in iron-overloaded rat hepatic cells when compared with controls.	Iron	47-51	transferrin receptor	Rattus norvegicus	26-29
7788730-8	1995	In the iron-overloaded rats, the staining intensity of iron was stronger in zone 1 than in zone 2 and 3, similar to the distribution pattern of TfR and Tf.	Iron	7-11	transferrin receptor	Rattus norvegicus	144-147
7788730-9	1995	These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats.	Iron	32-36	transferrin receptor	Rattus norvegicus	98-101
7788730-9	1995	These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats.	Iron	32-36	transferrin receptor	Rattus norvegicus	140-143
7788730-9	1995	These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats.	Iron	225-229	transferrin receptor	Rattus norvegicus	140-143
7788730-9	1995	These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats.	Iron	225-229	transferrin receptor	Rattus norvegicus	140-143
7787990-8	1995	The staining intensity of TfR, Tf and Ft increased in hepatocytes of iron-deficient rats and decreased in that of the iron-overloaded in comparison with the control rats.	Iron	69-73	transferrin receptor	Rattus norvegicus	26-29
7787990-8	1995	The staining intensity of TfR, Tf and Ft increased in hepatocytes of iron-deficient rats and decreased in that of the iron-overloaded in comparison with the control rats.	Iron	118-122	transferrin receptor	Rattus norvegicus	26-29
7533289-1	1995	Iron-regulatory protein (IRP) is a master regulator of cellular iron homeostasis.	Iron	64-68	wingless-type MMTV integration site family, member 2	Mus musculus	0-23
7533289-1	1995	Iron-regulatory protein (IRP) is a master regulator of cellular iron homeostasis.	Iron	64-68	wingless-type MMTV integration site family, member 2	Mus musculus	25-28
7533289-2	1995	Expression of several genes involved in iron uptake, storage, and utilization is regulated by binding of IRP to iron-responsive elements (IREs), structural motifs within the untranslated regions of their mRNAs.	Iron	40-44	wingless-type MMTV integration site family, member 2	Mus musculus	105-108
7533289-2	1995	Expression of several genes involved in iron uptake, storage, and utilization is regulated by binding of IRP to iron-responsive elements (IREs), structural motifs within the untranslated regions of their mRNAs.	Iron	112-116	wingless-type MMTV integration site family, member 2	Mus musculus	105-108
7533289-3	1995	IRP-binding to IREs is controlled by cellular iron availability.	Iron	46-50	wingless-type MMTV integration site family, member 2	Mus musculus	0-3
7533289-4	1995	Recent work revealed that nitric oxide (NO) can mimic the effect of iron chelation on IRP and on ferritin mRNA translation, whereas the stabilization of transferrin receptor mRNA following NO-mediated IRP activation could not be observed in gamma-interferon/lipopolysaccharide-stimulated murine macrophages.	Iron	68-72	wingless-type MMTV integration site family, member 2	Mus musculus	86-89
7533289-8	1995	Furthermore, iron starvation and NO release are shown to be independent signals to IRP.	Iron	13-17	wingless-type MMTV integration site family, member 2	Mus musculus	83-86
7743135-2	1995	The diphtheria toxin repressor (DtxR) plays a key role in this iron-dependent, global regulatory system and is the prototype for a new family of iron-dependent repressor proteins in Gram-positive bacteria.	Iron	63-67	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
7743135-2	1995	The diphtheria toxin repressor (DtxR) plays a key role in this iron-dependent, global regulatory system and is the prototype for a new family of iron-dependent repressor proteins in Gram-positive bacteria.	Iron	63-67	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
7743135-2	1995	The diphtheria toxin repressor (DtxR) plays a key role in this iron-dependent, global regulatory system and is the prototype for a new family of iron-dependent repressor proteins in Gram-positive bacteria.	Iron	145-149	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
7743135-2	1995	The diphtheria toxin repressor (DtxR) plays a key role in this iron-dependent, global regulatory system and is the prototype for a new family of iron-dependent repressor proteins in Gram-positive bacteria.	Iron	145-149	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
7840606-2	1995	At low cytosolic iron level, IRE-BP is activated and binds to stem-loop untranslated regions (IRE regions) of transferrin and ferritin mRNAs, activating and inhibiting their translations, respectively.	Iron	17-21	ferritin, mitochondrial	Cricetulus griseus	126-134
7591532-1	1995	This study was undertaken to estimate if dietary iron could stimulate factors which promote spontaneous lung tumorigenesis in A/J mice, by measuring biochemical parameters of oxidative stress on pulmonary nuclei, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) activities as markers of tumor promotion.	Iron	49-53	spermidine/spermine N1-acetyl transferase 1	Mus musculus	247-287
7591532-1	1995	This study was undertaken to estimate if dietary iron could stimulate factors which promote spontaneous lung tumorigenesis in A/J mice, by measuring biochemical parameters of oxidative stress on pulmonary nuclei, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) activities as markers of tumor promotion.	Iron	49-53	spermidine/spermine N1-acetyl transferase 1	Mus musculus	289-292
7591532-4	1995	Pulmonary ODC and SAT activities showed increasing tendency on feeding excess iron for 28 weeks.	Iron	78-82	spermidine/spermine N1-acetyl transferase 1	Mus musculus	18-21
9975880-0	1994	Delocalization of the Fe 3d levels in the quasi-two-dimensional correlated insulator FePS3.	Iron	22-24	sodium voltage-gated channel alpha subunit 11	Homo sapiens	85-90
7834053-5	1994	We have investigated the inactivation of rabbit muscle creatine kinase by hydrogen peroxide and by xanthine oxidase generated superoxide or Adriamycin radicals in the presence of iron catalysts.	Iron	179-183	creatine kinase M-type	Oryctolagus cuniculus	48-70
7943298-0	1994	Placental transferrin receptor in diabetic pregnancies with increased fetal iron demand.	Iron	76-80	transferrin receptor	Homo sapiens	10-30
7943298-4	1994	TR immunoreactivity was localized to the syncytiotrophoblast in both groups, was greater in the diabetic group, and was inversely correlated with fetal storage iron (r = -0.75; P &lt; 0.001).	Iron	160-164	transferrin receptor	Homo sapiens	0-2
7943298-7	1994	This study provides in vivo evidence that fetal factors, such as iron demand or hyperinsulinemia, influence regulation of placental TR in humans.	Iron	65-69	transferrin receptor	Homo sapiens	132-134
7943298-8	1994	The increase in placental syncytiotrophoblastic TR expression associated with reduced cord serum ferritin concentration suggests that the fetus utilizes both increased placental iron transport and mobilization of fetal iron stores to support augmented fetal erythropoiesis.	Iron	178-182	transferrin receptor	Homo sapiens	48-50
7943298-8	1994	The increase in placental syncytiotrophoblastic TR expression associated with reduced cord serum ferritin concentration suggests that the fetus utilizes both increased placental iron transport and mobilization of fetal iron stores to support augmented fetal erythropoiesis.	Iron	219-223	transferrin receptor	Homo sapiens	48-50
7533507-7	1994	Pretreatment with neuraminidase inhibited the cationic colloidal iron staining at pH 1.5 on the mesothelial free surface.	Iron	65-69	neuraminidase 1	Homo sapiens	18-31
7944382-4	1994	Treatment of GR with any of the mentioned oxidants resulted in formation of carbonyl groups and inactivation except when treated with iron, where the observed carbonyl formation was not accompanied with significant activity loss.	Iron	134-138	glutathione-disulfide reductase	Homo sapiens	13-15
7866351-5	1994	However, the response to one of the major iron-regulated outer membrane antigens, the transferrin binding protein 2 (TBP2), was unaffected by the culture medium or the model, human or mouse, used for the analysis.	Iron	42-46	TATA-box binding protein like 2	Homo sapiens	86-115
7845533-2	1994	The iron transport protein transferrin is the major transport protein for aluminium, and aluminium gains access to cells by means of a specific cell surface transferrin receptor.	Iron	4-8	transferrin receptor	Homo sapiens	157-177
8080446-7	1994	However, artemisinin enhanced the inhibitory effect of iron (50 microM)-ascorbate (500 microM) on ATPase activity (46.3 +/- 3.9 vs 63 +/- 2.1% for basal; 57.2 +/- 2.5 vs 74.8 +/- 2.1% for CaM-activated).	Iron	55-59	dynein axonemal heavy chain 8	Homo sapiens	98-104
7518918-8	1994	This region includes cysteine residues 503 and 506 which have been shown to be required for iron-sulfur cluster assembly and for iron regulation of the IRE-BP.	Iron	129-133	aconitase 1	Homo sapiens	152-158
8021254-3	1994	IRF post-transcriptionally regulates intracellular iron levels via binding to IREs in the untranslated regions of ferritin, transferrin receptor, and erythroid 5-aminolevulinic-acid synthase mRNAs.	Iron	51-55	transferrin receptor	Homo sapiens	124-190
7981322-9	1994	In the third assay the iron complex of CP94, [Fe(III) (CP94)3] is quantified.	Iron	23-27	beaded filament structural protein 1	Homo sapiens	55-59
7981322-11	1994	Calibration for both components, i.e. CP94 (assays 1 and 2) and its iron complex (assay 3) are linear with correlation coefficients &gt; 0.99 and are reproducible over the required concentration range of 0-500 microM for the free ligand and 0-100 microM for the iron complex.	Iron	262-266	beaded filament structural protein 1	Homo sapiens	38-42
7936843-1	1994	The serum transferrin receptor (TfR) level reflects iron status and the rate of erythropoiesis.	Iron	52-56	transferrin receptor	Homo sapiens	10-30
7936843-1	1994	The serum transferrin receptor (TfR) level reflects iron status and the rate of erythropoiesis.	Iron	52-56	transferrin receptor	Homo sapiens	32-35
7936843-2	1994	This study was undertaken to assess the role of serum TfR in the iron status and erythropoiesis in very-low-birth-weight infants under conditions in which erythropoiesis is stimulated by large doses of recombinant human erythropoietin (rHuEPO) and oral iron.	Iron	65-69	transferrin receptor	Homo sapiens	54-57
7936843-11	1994	The very-low-birth-weight infants who were given large doses of rHuEPO and iron had a marked rise in serum TfR concentration and a small decline in serum ferritin concentration.	Iron	75-79	transferrin receptor	Homo sapiens	107-110
8016074-6	1994	It is known that His-504 in soybean lipoxygenase 1, which corresponds to His-532 in lipoxygenase 2, is one of the iron-binding ligands essential for lipoxygenase activity.	Iron	114-118	seed linoleate 9S-lipoxygenase-2	Glycine max	84-98
7954100-4	1994	Our data showed that (i) on a percentage basis the renin system supports blood pressure essentially in the same manner in normal and hypertensive rats, (ii) peripheral vascular resistance decreased when erythrocytosis was partially blocked by feeding a low-iron diet, (iii) blood volume was similar in normal and hypertensive rats, and (iv) dextrin stimulates plasma renin, packed cell volume, and blood pressure in hypertensive rats.	Iron	257-261	renin	Rattus norvegicus	51-56
7513628-4	1994	This study suggests that serum TfR measurement is a reliable index of iron depletion and potentially of importance in the diagnosis of iron-deficiency anemia.	Iron	70-74	transferrin receptor	Homo sapiens	31-34
7909515-1	1994	The stability of transferrin receptor (TfR) mRNA is regulated by iron availability.	Iron	65-69	transferrin receptor	Homo sapiens	17-37
7909515-1	1994	The stability of transferrin receptor (TfR) mRNA is regulated by iron availability.	Iron	65-69	transferrin receptor	Homo sapiens	39-42
7913056-1	1994	OBJECTIVE: To determine the changes in serum iron levels, if any, as a biochemical marker of pregnancy-induced hypertension (PIH).	Iron	45-49	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	125-128
7913056-5	1994	RESULTS: Subjects with PIH were found to have higher serum iron levels at diagnosis of PIH (recruitment value) and at termination of pregnancy than the controls (P &lt; 0.001).	Iron	59-63	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	23-26
7913056-5	1994	RESULTS: Subjects with PIH were found to have higher serum iron levels at diagnosis of PIH (recruitment value) and at termination of pregnancy than the controls (P &lt; 0.001).	Iron	59-63	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	87-90
7913056-6	1994	Serum iron levels in the PIH subjects decreased markedly in the postpartum period simultaneously with the clinical recovery from PIH.	Iron	6-10	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	25-28
7913056-6	1994	Serum iron levels in the PIH subjects decreased markedly in the postpartum period simultaneously with the clinical recovery from PIH.	Iron	6-10	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	129-132
7913056-7	1994	Serum iron values of &gt; or = 110 micrograms/dl was found to differentiate PIH from normotensive pregnancies with a sensitivity and specificity of 89% and 90%, respectively.	Iron	6-10	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	76-79
7913056-8	1994	CONCLUSIONS: Changes in serum iron levels correlated with the clinical course of PIH and appeared to be a uniform and specific biochemical marker of PIH although its correlation with the severity of PIH was found to be poor.	Iron	30-34	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	81-84
7913056-8	1994	CONCLUSIONS: Changes in serum iron levels correlated with the clinical course of PIH and appeared to be a uniform and specific biochemical marker of PIH although its correlation with the severity of PIH was found to be poor.	Iron	30-34	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	149-152
7913056-8	1994	CONCLUSIONS: Changes in serum iron levels correlated with the clinical course of PIH and appeared to be a uniform and specific biochemical marker of PIH although its correlation with the severity of PIH was found to be poor.	Iron	30-34	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	149-152
8145237-11	1994	The results are consistent with the hypothesis that CYP1A1 produces NAPQI preferentially because of closer proximity of the heme iron to the amide nitrogen, whereas CYP2B1 produces 3-OH-APAP preferentially because of closer proximity of the heme iron to the phenolic oxygen in this isoform.	Iron	246-250	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	165-171
7906714-3	1994	Recently, it was suggested that abnormal iron metabolism may play a crucial role in neuroleptic-induced dopamine D2 receptor super-sensitivity.	Iron	41-45	dopamine receptor D2	Homo sapiens	104-124
8108417-4	1994	The P. aeruginosa PhhA appears to contain iron and is pterin dependent.	Iron	42-46	phenylalanine hydroxylase	Homo sapiens	18-22
8171275-4	1994	Mean s-TfR levels in both patients with adequate iron and depleted iron stores were within the normal range, but tended to be higher than in normal individuals [mean (SD): 1.54 (0.43) mg l-1].	Iron	49-53	transferrin receptor	Homo sapiens	7-10
8171275-4	1994	Mean s-TfR levels in both patients with adequate iron and depleted iron stores were within the normal range, but tended to be higher than in normal individuals [mean (SD): 1.54 (0.43) mg l-1].	Iron	67-71	transferrin receptor	Homo sapiens	7-10
8293473-0	1994	The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.	Iron	82-86	ferroxidase FET3	Saccharomyces cerevisiae S288C	4-8
2558579-8	1989	Therefore, these molecular species, which are likely to occur in the gastrointestinal tract of the infant, may contribute to the high degree of iron absorption from human milk lactoferrin.	Iron	144-148	lactotransferrin	Bos taurus	176-187
8293473-7	1994	We suggest that the catalytic activity of the Fet3 protein is required for cellular iron accumulation.	Iron	84-88	ferroxidase FET3	Saccharomyces cerevisiae S288C	46-50
8290565-1	1994	The iron-responsive element-binding protein (IRE-BP) binds to specific stem-loop RNA structures known as iron-responsive elements (IREs) present in a variety of cellular mRNAs (e.g., those encoding ferritin, erythroid 5-aminolevulinate synthase, and transferrin receptor).	Iron	4-8	aconitase 1	Homo sapiens	45-51
2601708-1	1989	The 5" untranslated region of the ferritin heavy-chain mRNA contains a stem-loop structure called an iron-responsive element (IRE), that is solely responsible for the iron-mediated control of ferritin translation.	Iron	101-105	ferritin heavy chain 1	Homo sapiens	34-54
2601708-1	1989	The 5" untranslated region of the ferritin heavy-chain mRNA contains a stem-loop structure called an iron-responsive element (IRE), that is solely responsible for the iron-mediated control of ferritin translation.	Iron	167-171	ferritin heavy chain 1	Homo sapiens	34-54
8290565-3	1994	The IRE-BP is identical in sequence to cytosolic aconitase, and the function of the protein is determined by the presence or absence of an Fe-S cluster.	Iron	139-143	aconitase 1	Homo sapiens	4-10
8290565-7	1994	Modeling based on probable structural similarities between the previously crystallized mitochondrial aconitase and the IRE-BP predicts that these residues would be accessible to the IRE only were there a major change in the predicted conformation of the protein when cells are iron-depleted.	Iron	277-281	aconitase 1	Homo sapiens	119-125
8262977-1	1993	Phosphorylation by protein kinase C. The iron-responsive element-binding protein (IRE-BP) is a cytosolic RNA-binding protein that functions in the maintenance of iron homeostasis by post-transcriptionally regulating transferrin receptor and ferritin synthesis.	Iron	41-45	transferrin receptor	Rattus norvegicus	216-236
2676016-2	1989	In this study, endotoxin-depleted, purified iron-saturated human Lf was assessed for its effect on the production of interleukin-1 by cultured monocytes and their subsequent effect on colony-stimulating factor release from cultured fibroblasts.	Iron	44-48	interleukin 1 alpha	Homo sapiens	117-130
8262977-1	1993	Phosphorylation by protein kinase C. The iron-responsive element-binding protein (IRE-BP) is a cytosolic RNA-binding protein that functions in the maintenance of iron homeostasis by post-transcriptionally regulating transferrin receptor and ferritin synthesis.	Iron	162-166	transferrin receptor	Rattus norvegicus	216-236
8007816-3	1993	A combination of direct binding experiments and affinity isolation experiments demonstrated that this was due to a strong preference for binding of iron-saturated transferrin by transferrin binding protein 2 (Tbp2).	Iron	148-152	TATA-box binding protein like 2	Homo sapiens	178-207
2803243-4	1989	AMP-bound Fe was a minor component of the cytosol following rapid (NH1)2SO4 precipitation, and the major component when iron was released from transferrin by haemolysates.	Iron	10-12	inhibitor of carbonic anhydrase	Cavia porcellus	143-154
2803243-4	1989	AMP-bound Fe was a minor component of the cytosol following rapid (NH1)2SO4 precipitation, and the major component when iron was released from transferrin by haemolysates.	Iron	120-124	inhibitor of carbonic anhydrase	Cavia porcellus	143-154
8007816-3	1993	A combination of direct binding experiments and affinity isolation experiments demonstrated that this was due to a strong preference for binding of iron-saturated transferrin by transferrin binding protein 2 (Tbp2).	Iron	148-152	TATA-box binding protein like 2	Homo sapiens	209-213
8287560-6	1993	They increase to a higher level in cells cultured in iron-poor medium, indicating that iron has an effect on the TfR synthesis/breakdown ratio.	Iron	53-57	transferrin receptor	Homo sapiens	113-116
16666812-0	1989	Iron induction of ferritin synthesis in soybean cell suspensions.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	18-26
16666812-1	1989	In animal cells specialized for iron storage, iron-induced accumulation of ferritin is known to result from a shift of stored mRNA from the ribonucleoprotein fraction to polysomes.	Iron	32-36	ferritin-1, chloroplastic	Glycine max	75-83
16666812-1	1989	In animal cells specialized for iron storage, iron-induced accumulation of ferritin is known to result from a shift of stored mRNA from the ribonucleoprotein fraction to polysomes.	Iron	46-50	ferritin-1, chloroplastic	Glycine max	75-83
16666812-2	1989	Previous reports with bean leaves suggested that in plants iron induction of ferritin synthesis would result from a regulation at the transcriptional level (F van der Mark, F Bienfait, H van der Ende [1983] Biochem Biophys Res Commun 115:463-469).	Iron	59-63	ferritin-1, chloroplastic	Glycine max	77-85
16666812-5	1989	A good correlation is found between cellular iron content and the amount of ferritin accumulation.	Iron	45-49	ferritin-1, chloroplastic	Glycine max	76-84
16666812-8	1989	During the same time, this concentration of actinomycin D strongly inhibits the iron-induced synthesis of ferritin.	Iron	80-84	ferritin-1, chloroplastic	Glycine max	106-114
16666812-9	1989	These results show that in soybean cell cultures, the mechanism of regulation of ferritin synthesis in response to iron does not result from recruitment of preexisting mRNA.	Iron	115-119	ferritin-1, chloroplastic	Glycine max	81-89
8287560-6	1993	They increase to a higher level in cells cultured in iron-poor medium, indicating that iron has an effect on the TfR synthesis/breakdown ratio.	Iron	87-91	transferrin receptor	Homo sapiens	113-116
8287560-8	1993	TfR distribution among these pools was modulated by culture time and iron.	Iron	69-73	transferrin receptor	Homo sapiens	0-3
2736234-9	1989	Presaturation of endogenous transferrin with oral carbonyl iron prevented iron release from the feto-placental unit back into the maternal circulation.	Iron	59-63	inhibitor of carbonic anhydrase	Cavia porcellus	28-39
2736234-9	1989	Presaturation of endogenous transferrin with oral carbonyl iron prevented iron release from the feto-placental unit back into the maternal circulation.	Iron	74-78	inhibitor of carbonic anhydrase	Cavia porcellus	28-39
8312724-3	1993	The experimental finding that ferric lactate transfers its iron to albumin and to ATP suggests that in the Ca(2+)-uptake modification it works through its iron transfer which provokes the inhibition of the cell calcium homeostasis regulatory systems (Ca(2+)-channels, intracellular Ca(2+)-binding sites and Ca(2+)-pump ATPase).	Iron	59-63	dynein, axonemal, heavy chain 8	Mus musculus	319-325
2660938-2	1989	At the molecular level, the main features are: the increased capacity of cells to bind toxic, inorganic iron to a specific storage protein, apoferritin, which becomes visible due to its iron-containing, electron-opaque core; since iron itself is involved in the de-repression of apoferritin synthesis, the number of assembled ferritin molecules depends on the amount of unbound iron present in the cell; there is a maximal, cell line-specific concentration of cytosolic ferritin; ferritin particles have a variable iron content, with richer molecules having a tendency to form clusters.	Iron	104-108	ferritin heavy chain 1	Homo sapiens	140-151
8312724-3	1993	The experimental finding that ferric lactate transfers its iron to albumin and to ATP suggests that in the Ca(2+)-uptake modification it works through its iron transfer which provokes the inhibition of the cell calcium homeostasis regulatory systems (Ca(2+)-channels, intracellular Ca(2+)-binding sites and Ca(2+)-pump ATPase).	Iron	155-159	dynein, axonemal, heavy chain 8	Mus musculus	319-325
2660938-2	1989	At the molecular level, the main features are: the increased capacity of cells to bind toxic, inorganic iron to a specific storage protein, apoferritin, which becomes visible due to its iron-containing, electron-opaque core; since iron itself is involved in the de-repression of apoferritin synthesis, the number of assembled ferritin molecules depends on the amount of unbound iron present in the cell; there is a maximal, cell line-specific concentration of cytosolic ferritin; ferritin particles have a variable iron content, with richer molecules having a tendency to form clusters.	Iron	104-108	ferritin heavy chain 1	Homo sapiens	279-290
8134170-0	1993	Serum transferrin receptor for assessment of iron status in healthy prepubertal and early pubertal boys.	Iron	45-49	transferrin receptor	Homo sapiens	6-26
2925237-2	1989	We studied this question by using a unique model in which mice homozygous for a deletion in the gene encoding for the beta-major globin develop moderate anemia, splenomegaly, and tissue iron overload, a syndrome similar to beta-thalassemia in humans.	Iron	186-190	hemoglobin, beta adult major chain	Mus musculus	118-135
8516332-3	1993	The calculated time dependence of the iron motion over 100 ps is in excellent agreement with the frequency shift of band III of the heme group [see Lim, M., Jackson, T. A.	Iron	38-42	PDZ and LIM domain 5	Homo sapiens	148-151
2535839-2	1989	Ceruloplasmin was also shown to inhibit superoxide-mediated mobilization of iron from ferritin, in a concentration-dependent manner, as measured spectrophotometrically using the iron(II) chelator bathophenanthroline sulfonate.	Iron	76-80	ceruloplasmin	Homo sapiens	0-13
8500729-0	1993	Rat duodenal iron-binding protein mobilferrin is a homologue of calreticulin.	Iron	13-17	calreticulin	Rattus norvegicus	64-76
2539862-2	1989	The knowledge of the route through which iron can enter and leave the apoferritin shell is a prerequisite for the understanding of ferritin"s function.	Iron	41-45	ferritin heavy chain 1	Homo sapiens	70-81
2539862-6	1989	In particular, the introduction of the additional carboxylate carried by p-(chloromercuri)benzoate near Asp-127 and Glu-130 increases the initial rate of iron uptake and affects the coordination geometry of the metal in the Fe(III)-apoferritin complex as indicated by optical absorption and EPR data.	Iron	154-158	ferritin heavy chain 1	Homo sapiens	232-243
8500729-9	1993	CONCLUSIONS: Mobilferrin and calreticulin are homologues that bind iron with greater affinity than calcium and other transitional metals.	Iron	67-71	calreticulin	Rattus norvegicus	29-41
8347279-1	1993	Iron regulatory elements (IREs) are a family of 28 nucleotide, non-coding elements which regulate the translation of ferritin mRNA (iron storage), erythroid delta-aminolevulinic acid synthase mRNA (heme synthesis) and the stability of the transferrin receptor (TfR) mRNA (iron uptake).	Iron	0-4	transferrin receptor	Homo sapiens	239-259
2568668-4	1989	On semisynthetic iron-depleted diet GSH-T and GGT activities were further depressed, but this was accompanied with an additional depression of GSH, glutathione reductase (GSSG-R), and glutathione peroxidase (GSH-Px) activities and lipid peroxide concentrations.	Iron	17-21	glutathione-disulfide reductase	Rattus norvegicus	148-169
8347279-1	1993	Iron regulatory elements (IREs) are a family of 28 nucleotide, non-coding elements which regulate the translation of ferritin mRNA (iron storage), erythroid delta-aminolevulinic acid synthase mRNA (heme synthesis) and the stability of the transferrin receptor (TfR) mRNA (iron uptake).	Iron	0-4	transferrin receptor	Homo sapiens	261-264
8347279-1	1993	Iron regulatory elements (IREs) are a family of 28 nucleotide, non-coding elements which regulate the translation of ferritin mRNA (iron storage), erythroid delta-aminolevulinic acid synthase mRNA (heme synthesis) and the stability of the transferrin receptor (TfR) mRNA (iron uptake).	Iron	272-276	transferrin receptor	Homo sapiens	239-259
3255681-0	1988	Studies on distribution and changes in concentration of iron and iron-dependent inhibitor protein of hydroxymethylglutaryl CoA reductase.	Iron	56-60	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	101-136
8347279-1	1993	Iron regulatory elements (IREs) are a family of 28 nucleotide, non-coding elements which regulate the translation of ferritin mRNA (iron storage), erythroid delta-aminolevulinic acid synthase mRNA (heme synthesis) and the stability of the transferrin receptor (TfR) mRNA (iron uptake).	Iron	272-276	transferrin receptor	Homo sapiens	261-264
3255681-0	1988	Studies on distribution and changes in concentration of iron and iron-dependent inhibitor protein of hydroxymethylglutaryl CoA reductase.	Iron	65-69	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	101-136
8347279-3	1993	The specific regulator protein, the IRE-BP, is a member of the aconitase family but binds RNA only in the apo form without the Fe-S cluster.	Iron	127-131	aconitase 1	Homo sapiens	36-42
8347279-4	1993	Cellular iron alters the IRE/IRE-BP interaction leading to translation of ferritin and eALAS mRNAs but degradation of the TfR mRNA.	Iron	9-13	aconitase 1	Homo sapiens	29-35
8347279-4	1993	Cellular iron alters the IRE/IRE-BP interaction leading to translation of ferritin and eALAS mRNAs but degradation of the TfR mRNA.	Iron	9-13	transferrin receptor	Homo sapiens	122-125
2844764-1	1988	The oxidation of yeast cytochrome c peroxidase by hydrogen peroxide produces a unique enzyme intermediate, cytochrome c peroxidase Compound I, in which the ferric heme iron has been oxidized to an oxyferryl state, Fe(IV), and an amino acid residue has been oxidized to a radical state.	Iron	168-172	cytochrome c, somatic	Equus caballus	23-35
2844764-1	1988	The oxidation of yeast cytochrome c peroxidase by hydrogen peroxide produces a unique enzyme intermediate, cytochrome c peroxidase Compound I, in which the ferric heme iron has been oxidized to an oxyferryl state, Fe(IV), and an amino acid residue has been oxidized to a radical state.	Iron	168-172	cytochrome c, somatic	Equus caballus	107-119
8347279-10	1993	The effect of cellular iron, Fe-S clusters and heme on the IRE-BP/RNA is not completely understood.	Iron	29-33	aconitase 1	Homo sapiens	59-65
8478396-0	1993	Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration.	Iron	74-78	nerve growth factor	Rattus norvegicus	11-14
2906908-0	1988	Iron exerts a specific inhibitory effect on CD2 expression of human PBL.	Iron	0-4	CD2 molecule	Homo sapiens	44-47
8478396-7	1993	Basic fibroblast growth factor (bFGF), nerve growth factor (NGF), and insulin-like growth factors (IGF-I and IGF-II) each protected neurons against iron-induced damage.	Iron	148-152	fibroblast growth factor 2	Rattus norvegicus	0-30
3391251-9	1988	Parenteral iron administration during the Cd drinking period could completely prevent the development of iron deficiency anemia and the increase of both CFU-E and plasma EPO.	Iron	11-15	erythropoietin	Rattus norvegicus	170-173
8478396-7	1993	Basic fibroblast growth factor (bFGF), nerve growth factor (NGF), and insulin-like growth factors (IGF-I and IGF-II) each protected neurons against iron-induced damage.	Iron	148-152	fibroblast growth factor 2	Rattus norvegicus	32-36
8478396-7	1993	Basic fibroblast growth factor (bFGF), nerve growth factor (NGF), and insulin-like growth factors (IGF-I and IGF-II) each protected neurons against iron-induced damage.	Iron	148-152	nerve growth factor	Rattus norvegicus	39-58
8478396-7	1993	Basic fibroblast growth factor (bFGF), nerve growth factor (NGF), and insulin-like growth factors (IGF-I and IGF-II) each protected neurons against iron-induced damage.	Iron	148-152	nerve growth factor	Rattus norvegicus	60-63
8495200-6	1993	The monomer-monomer interactions typical of bacterial Fe- and Mn-containing SODs are retained in the human enzyme, but the dimer-dimer interactions that form the tetramer are very different from those found in the structure of MnSOD from T. thermophilus.	Iron	54-56	superoxide dismutase 2	Homo sapiens	227-232
2840749-8	1988	The catalase sensitivity and iron dependency of C5a generation suggest that hydroxyl radical may be related to complement activation and C5a appearance.	Iron	29-33	complement C5	Rattus norvegicus	48-51
2840749-8	1988	The catalase sensitivity and iron dependency of C5a generation suggest that hydroxyl radical may be related to complement activation and C5a appearance.	Iron	29-33	complement C5	Rattus norvegicus	137-140
8469289-9	1993	We propose that the mk mutation results in an impaired form of NF-E2 which fails to regulate both globin production and iron metabolism properly.	Iron	120-124	nuclear factor, erythroid derived 2	Mus musculus	63-68
3372521-7	1988	This conformational change which plays a pivotal role in hemopexin function requires the bis-histidyl coordination with heme iron and leads to a tighter association between domain I and domain II shown by the co-migration of heme-domain I and domain II in sucrose gradients.	Iron	125-129	hemopexin	Mus musculus	57-66
3372522-6	1988	However, as expected from the differences in the coordination chemistries of tin and iron, the stability of the histidyl-metalloporphyrin complex is lower for SnPP-hemopexin than for mesoheme-hemopexin.	Iron	85-89	hemopexin	Mus musculus	164-173
8492277-5	1993	Using discriminant analysis, performance on the Mental Processing Composite of the K-ABC 1 month after treatment in combination with increases in blood Hgb resulted in the successful classification of 74% in terms whether a child had received both iron supplement and vermifuge treatment (p = .007).	Iron	248-252	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	85-88
3377511-8	1988	The results are consistent with the hypothesis that gastrin and transferrin act synergistically in the uptake of dietary iron by the gastrointestinal tract.	Iron	121-125	gastrin	Homo sapiens	52-59
8425536-2	1993	The effect of the paramagnetic high-spin Fe(III) ion in phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1) on the water proton longitudinal relaxation rate has been used to study the environment of the iron center.	Iron	207-211	phenylalanine hydroxylase	Homo sapiens	56-85
2837228-4	1988	EPR spectra indicated that the structure of myeloperoxidase surrounding the heme iron changed from a rhombic form into an axial one by the repeated administration of PTU.	Iron	81-85	myeloperoxidase	Rattus norvegicus	44-59
3134296-7	1988	These observations strongly suggest that the enhanced TfR synthesis elicited by rIL-2 is mediated by depletion of a regulatory intracellular iron pool.	Iron	141-145	interleukin 2	Rattus norvegicus	80-85
8425536-2	1993	The effect of the paramagnetic high-spin Fe(III) ion in phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1) on the water proton longitudinal relaxation rate has been used to study the environment of the iron center.	Iron	207-211	phenylalanine hydroxylase	Homo sapiens	87-112
8485201-1	1993	Transferrin receptor (TfR) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin, the major iron-carrier protein.	Iron	77-81	transferrin receptor	Homo sapiens	0-20
8485201-1	1993	Transferrin receptor (TfR) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin, the major iron-carrier protein.	Iron	77-81	transferrin receptor	Homo sapiens	22-25
8485201-1	1993	Transferrin receptor (TfR) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin, the major iron-carrier protein.	Iron	147-151	transferrin receptor	Homo sapiens	0-20
8485201-1	1993	Transferrin receptor (TfR) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin, the major iron-carrier protein.	Iron	147-151	transferrin receptor	Homo sapiens	22-25
8485201-5	1993	Recent studies have shed light on the molecular basis by which iron regulates TfR expression.	Iron	63-67	transferrin receptor	Homo sapiens	78-81
8485201-6	1993	Thus, the 3" untranslated region of TfR mRNA contains a cis-acting RNA element, termed the iron-regulatory element (IRE), that interacts with an IRE-binding protein (IRE-BP).	Iron	91-95	transferrin receptor	Homo sapiens	36-39
3128478-2	1988	Expression of lactoferrin-binding activity was regulated by the level of iron in the medium, so that growth in the presence of the iron chelator EDDA (ethylenediamine di-ortho-hydroxyphenylacetic acid) resulted in a greater than 350-fold increase in binding activity, which was reversed by addition of excess iron.	Iron	73-77	lactotransferrin	Bos taurus	14-25
3128478-2	1988	Expression of lactoferrin-binding activity was regulated by the level of iron in the medium, so that growth in the presence of the iron chelator EDDA (ethylenediamine di-ortho-hydroxyphenylacetic acid) resulted in a greater than 350-fold increase in binding activity, which was reversed by addition of excess iron.	Iron	131-135	lactotransferrin	Bos taurus	14-25
3128478-2	1988	Expression of lactoferrin-binding activity was regulated by the level of iron in the medium, so that growth in the presence of the iron chelator EDDA (ethylenediamine di-ortho-hydroxyphenylacetic acid) resulted in a greater than 350-fold increase in binding activity, which was reversed by addition of excess iron.	Iron	131-135	lactotransferrin	Bos taurus	14-25
3128478-5	1988	The binding specificity for human lactoferrin correlated with growth studies in which human but not bovine lactoferrin could support the growth of iron-starved cells.	Iron	147-151	lactotransferrin	Bos taurus	34-45
3128478-6	1988	Binding of lactoferrin was not dependent on its level of iron saturation, since iron-saturated lactoferrin and apolactoferrin were equally effective at blocking binding of HRP-lactoferrin in competitive binding assays.	Iron	80-84	lactotransferrin	Bos taurus	11-22
3128478-6	1988	Binding of lactoferrin was not dependent on its level of iron saturation, since iron-saturated lactoferrin and apolactoferrin were equally effective at blocking binding of HRP-lactoferrin in competitive binding assays.	Iron	80-84	lactotransferrin	Bos taurus	95-106
3128478-6	1988	Binding of lactoferrin was not dependent on its level of iron saturation, since iron-saturated lactoferrin and apolactoferrin were equally effective at blocking binding of HRP-lactoferrin in competitive binding assays.	Iron	80-84	lactotransferrin	Bos taurus	95-106
3128478-7	1988	The lactoferrin-binding protein was identified as a 105,000-molecular-weight iron-regulated outer membrane protein in three different meningococcal strains by a batch affinity method with biotinylated human lactoferrin and streptavidin-agarose.	Iron	77-81	lactotransferrin	Bos taurus	4-15
3128478-7	1988	The lactoferrin-binding protein was identified as a 105,000-molecular-weight iron-regulated outer membrane protein in three different meningococcal strains by a batch affinity method with biotinylated human lactoferrin and streptavidin-agarose.	Iron	77-81	lactotransferrin	Bos taurus	207-218
8485201-6	1993	Thus, the 3" untranslated region of TfR mRNA contains a cis-acting RNA element, termed the iron-regulatory element (IRE), that interacts with an IRE-binding protein (IRE-BP).	Iron	91-95	aconitase 1	Homo sapiens	145-164
8485201-6	1993	Thus, the 3" untranslated region of TfR mRNA contains a cis-acting RNA element, termed the iron-regulatory element (IRE), that interacts with an IRE-binding protein (IRE-BP).	Iron	91-95	aconitase 1	Homo sapiens	166-172
8264340-9	1993	Owing to the second messenger function of ROS in activating transcription factors (NF-kB, AP-1) and to the ability of Mn to facilitate the dismutation of O2- to H2O2 and of Fe to participate in the Fenton reaction, we propose that in the early stage of carcinogenesis an impairment of the signal transduction machinery, related to the metal deficiency, might limit the binding to DNA of transcription factors and cause the defect in the MnSOD gene expression.	Iron	173-175	superoxide dismutase 2	Homo sapiens	437-442
1457588-7	1992	The sTfR rise may be explained by an increase in erythroid precursor cell mass or increased TfR expression and a decrease in tissue iron stores, although direct effects of Epo on TfR regulation cannot be excluded.	Iron	132-136	transferrin receptor	Homo sapiens	5-8
1334975-9	1992	IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes.	Iron	38-42	Ras-like without CAAX 2	Rattus norvegicus	65-68
1334975-9	1992	IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes.	Iron	136-140	Ras-like without CAAX 2	Rattus norvegicus	65-68
1445835-10	1992	Through the use of Fe.EDTA-GCN4(226-281) as a sequence-specific footprinting agent, it is shown that the dimeric protein GCN4-(226-281) and the dimeric peptide 2-ImN can simultaneously occupy their common binding site in the major and minor grooves of DNA, respectively.	Iron	19-21	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	27-31
1445835-10	1992	Through the use of Fe.EDTA-GCN4(226-281) as a sequence-specific footprinting agent, it is shown that the dimeric protein GCN4-(226-281) and the dimeric peptide 2-ImN can simultaneously occupy their common binding site in the major and minor grooves of DNA, respectively.	Iron	19-21	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	121-125
1524435-8	1992	These results provide evidence for ceruloplasmin as an effective catalyst for the incorporation of iron into both apo- and holoferritin.	Iron	99-103	ceruloplasmin	Rattus norvegicus	35-48
1431880-3	1992	Two components of this regulatory system have been defined: a cis-acting mRNA sequence/structure motif called "iron-responsive element" (IRE) and a specific trans-acting cytoplasmic binding protein, here referred to as "IRE-binding protein" (IRE-BP).	Iron	111-115	aconitase 1	Homo sapiens	242-248
1431880-4	1992	As an early event in the regulatory cascade, cellular iron deprivation induces the IRE-binding activity of IRE-BP, whereas binding activity is reduced in iron-replete cells.	Iron	54-58	aconitase 1	Homo sapiens	107-113
1431880-4	1992	As an early event in the regulatory cascade, cellular iron deprivation induces the IRE-binding activity of IRE-BP, whereas binding activity is reduced in iron-replete cells.	Iron	154-158	aconitase 1	Homo sapiens	107-113
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	Iron	45-49	aconitase 1	Homo sapiens	13-19
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	Iron	45-49	aconitase 1	Homo sapiens	172-178
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	Iron	179-183	aconitase 1	Homo sapiens	13-19
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	Iron	179-183	aconitase 1	Homo sapiens	172-178
1431880-10	1992	In contrast, iron uptake is largely regulated via multiple IREs in the 3" UTR of transferrin receptor (TfR) mRNA.	Iron	13-17	transferrin receptor	Homo sapiens	81-101
1431880-10	1992	In contrast, iron uptake is largely regulated via multiple IREs in the 3" UTR of transferrin receptor (TfR) mRNA.	Iron	13-17	transferrin receptor	Homo sapiens	103-106
1431880-11	1992	TfR-IREs are required for the iron-sensitive control of TfR mRNA stability.	Iron	30-34	transferrin receptor	Homo sapiens	0-3
1431880-11	1992	TfR-IREs are required for the iron-sensitive control of TfR mRNA stability.	Iron	30-34	transferrin receptor	Homo sapiens	56-59
1431880-13	1992	As a result of these regulatory interactions, iron starvation induces the expression of TfR, thereby increasing iron uptake, and represses the synthesis of proteins involved in iron storage and utilization.	Iron	46-50	transferrin receptor	Homo sapiens	88-91
1431880-13	1992	As a result of these regulatory interactions, iron starvation induces the expression of TfR, thereby increasing iron uptake, and represses the synthesis of proteins involved in iron storage and utilization.	Iron	112-116	transferrin receptor	Homo sapiens	88-91
1431880-13	1992	As a result of these regulatory interactions, iron starvation induces the expression of TfR, thereby increasing iron uptake, and represses the synthesis of proteins involved in iron storage and utilization.	Iron	112-116	transferrin receptor	Homo sapiens	88-91
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	20-24	aconitase 1	Homo sapiens	140-146
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	20-24	aconitase 1	Homo sapiens	190-196
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	110-114	aconitase 1	Homo sapiens	140-146
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	110-114	aconitase 1	Homo sapiens	190-196
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	170-174	aconitase 1	Homo sapiens	140-146
1502165-6	1992	The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.	Iron	170-174	aconitase 1	Homo sapiens	190-196
1331744-0	1992	[Alterations of plasma iron level in laparotomy of rats--suppressive effect of leukotriene B4 receptor antagonist on the drop in plasma iron--preliminary report].	Iron	136-140	leukotriene B4 receptor	Rattus norvegicus	79-102
1597581-1	1992	Two iron-binding proteins, lactoferrin and transferrin, are present in ruminant milk.	Iron	4-8	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	43-54
1316633-3	1992	The effect of iron on FRP degradation is enhanced by porphyrin precursors but is decreased by inhibitors of porphyrin synthesis, which implies that heme is an active agent.	Iron	14-18	aconitase 1	Homo sapiens	22-25
1591271-1	1992	The uptake of non-transferrin-bound iron, Fe(II), transferrin-bound iron, Tf-Fe and transferrin was studied in reticulocytes from anaemic rabbits during maturation and then synchronized regeneration in vivo (following injection of actinomycin D) and while maturing during in vitro incubation.	Iron	68-72	serotransferrin	Oryctolagus cuniculus	50-61
1591271-1	1992	The uptake of non-transferrin-bound iron, Fe(II), transferrin-bound iron, Tf-Fe and transferrin was studied in reticulocytes from anaemic rabbits during maturation and then synchronized regeneration in vivo (following injection of actinomycin D) and while maturing during in vitro incubation.	Iron	68-72	serotransferrin	Oryctolagus cuniculus	50-61
1591271-2	1992	The uptake of Fe(II) and Tf-Fe decreased in parallel with each other and with the reticulocyte count and transferrin uptake during maturation in vivo and in vitro.	Iron	14-16	serotransferrin	Oryctolagus cuniculus	105-116
1591271-6	1992	The loss of transferrin receptors and the uptake of iron from transferrin during reticulocyte maturation was not associated with a change in the affinity of the receptors for transferrin, in the relative distribution of the receptors between the outer cell membrane and intracellular sites or in the ability of the transferrin molecule to donate two iron atoms to the cell with each intracellular cycle, but the average duration of the cycle increased.	Iron	52-56	serotransferrin	Oryctolagus cuniculus	62-73
1591271-6	1992	The loss of transferrin receptors and the uptake of iron from transferrin during reticulocyte maturation was not associated with a change in the affinity of the receptors for transferrin, in the relative distribution of the receptors between the outer cell membrane and intracellular sites or in the ability of the transferrin molecule to donate two iron atoms to the cell with each intracellular cycle, but the average duration of the cycle increased.	Iron	52-56	serotransferrin	Oryctolagus cuniculus	62-73
1591271-6	1992	The loss of transferrin receptors and the uptake of iron from transferrin during reticulocyte maturation was not associated with a change in the affinity of the receptors for transferrin, in the relative distribution of the receptors between the outer cell membrane and intracellular sites or in the ability of the transferrin molecule to donate two iron atoms to the cell with each intracellular cycle, but the average duration of the cycle increased.	Iron	52-56	serotransferrin	Oryctolagus cuniculus	62-73
1565612-4	1992	Strains harboring simultaneous mutations in arcA/B and fur expressed sodA-lacZ under anaerobic growth conditions but were still inducible by iron chelators.	Iron	141-145	arginine deiminase	Escherichia coli	44-48
3356704-11	1988	The reaction of LOOH with phenylalanine hydroxylase strongly resembles the nonenzymatic reaction of LOOH with hematin, implying similar mechanisms for the two reactions and implicating the enzyme"s non-heme iron as both the site of reaction of LOOH and of electron transfer during oxidation and reduction.	Iron	207-211	phenylalanine hydroxylase	Rattus norvegicus	26-51
1432830-1	1992	A study of serum iron and ferritin levels in Indian women with pregnancy induced hypertension (PIH) (mild/severe) and eclampsia compared with controls of similar gestational ages, revealed that mean serum iron was elevated slightly in PIH and significantly in eclampsia as compared to controls.	Iron	205-209	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	95-98
2833279-5	1988	The data indicate that in the presence of no or small amounts of chelated iron in negatively-charged membranous systems, most of the hydrogen peroxide and superoxide anions necessary for generation of hydroxyl radicals, are produced by cytochrome P-450 LM2.	Iron	74-78	cytochrome P450 2B4	Oryctolagus cuniculus	236-256
1432830-1	1992	A study of serum iron and ferritin levels in Indian women with pregnancy induced hypertension (PIH) (mild/severe) and eclampsia compared with controls of similar gestational ages, revealed that mean serum iron was elevated slightly in PIH and significantly in eclampsia as compared to controls.	Iron	205-209	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	235-238
1541554-4	1992	Competition binding experiments indicated that this hemin-protein interaction was specific, since only hemin or heme-containing proteins, such as human hemoglobin and bovine catalase, but not protoporphyrin IX, iron-loaded human lactoferrin, or transferrin, could abrogate binding.	Iron	211-215	catalase	Bos taurus	174-182
3280607-6	1988	These findings suggest that amyloid P component, iron overload, or macrophage derived factors could have a role in the polymerisation of beta 2-microglobulin into amyloid deposit.	Iron	49-53	beta-2-microglobulin	Homo sapiens	137-157
1531003-5	1992	Kinetic analysis of rat ceruloplasmin produced a biphasic v vs v/s plot with apparent Km"s of 40 and 1.5 microM for iron.	Iron	116-120	ceruloplasmin	Rattus norvegicus	24-37
3478818-1	1987	Lactotransferrin (LTF), a member of the transferrin family of genes, is the major iron-binding protein in milk and body secretions.	Iron	82-86	lactotransferrin	Mus musculus	0-16
3478818-1	1987	Lactotransferrin (LTF), a member of the transferrin family of genes, is the major iron-binding protein in milk and body secretions.	Iron	82-86	lactotransferrin	Mus musculus	18-21
2444393-4	1987	In this report the presence of lactoferrin and transferrin in guinea pig tears was investigated using an iron-binding assay, Ouchterlony immunodiffusion, ELISA and immunoblotting techniques.	Iron	105-109	inhibitor of carbonic anhydrase	Cavia porcellus	47-58
1737056-13	1992	These results show that changes in ferritin and transferrin receptor caused by treatment with retinoic acid are similar to those induced by excess iron, and suggest that changes in these proteins during cell differentiation are due to redistribution of intracellular iron into the regulatory pool(s), rather than to iron-independent mechanisms.	Iron	267-271	transferrin receptor	Homo sapiens	48-68
3606128-2	1987	The data indicate that ferredoxin-thioredoxin reductase (FTR)--an iron-sulfur enzyme present in oxygenic photosynthetic organisms--is the first member of a thiol chain that links light to enzyme regulation.	Iron	66-70	thioredoxin	Homo sapiens	34-45
3663138-11	1987	Recent reports confirm that the two iron-binding domains of both OTf and human lactotransferrin associate non-covalently in solution.	Iron	36-40	transferrin (ovotransferrin)	Gallus gallus	65-68
1737056-13	1992	These results show that changes in ferritin and transferrin receptor caused by treatment with retinoic acid are similar to those induced by excess iron, and suggest that changes in these proteins during cell differentiation are due to redistribution of intracellular iron into the regulatory pool(s), rather than to iron-independent mechanisms.	Iron	267-271	transferrin receptor	Homo sapiens	48-68
1734036-11	1992	The results suggest that the depletion of cellular non-heme iron due to the increase in heme synthesis maintains a high level of transferrin receptor expression in differentiating erythroid cells even after the cessation of cell division.	Iron	60-64	transferrin receptor	Mus musculus	129-149
3036144-3	1987	The NO-ferrous cytochrome c" would be a mixture of NO complexes with six- and five-coordinate nitrosylheme, suggesting that the heme-iron to histidine bond in the ferrous cytochrome c" is more stable than that from chemoheterotrophic bacteria.	Iron	133-137	cytochrome c, somatic	Equus caballus	171-183
1315708-6	1992	The formation of 8-OH-dG in DNA by autooxidized methyl linolenate was dependent on the presence of the transition metal ions Cu or Fe and was inhibited by various scavengers, including superoxide dismutase and catalase.	Iron	131-133	catalase	Bos taurus	210-218
3036246-5	1987	Iron accumulation from transferrin was inhibited by ferritin to a greater extent than could be accounted for by the decreased rate of endocytosis.	Iron	0-4	inhibitor of carbonic anhydrase	Cavia porcellus	23-34
1308990-0	1992	Iron absorption via the mucin-integrin mobilferrin pathway.	Iron	0-4	LOC100508689	Homo sapiens	24-29
3038167-16	1987	Thus, the rate constant for reduction by horse cytochrome c of the peroxidase species in which only the heme iron atom is oxidized was decreased by only 38%, indicating that this oxidized side-chain group is not tightly coupled to the ferryl peroxidase heme iron.	Iron	109-113	cytochrome c, somatic	Equus caballus	47-59
3038167-16	1987	Thus, the rate constant for reduction by horse cytochrome c of the peroxidase species in which only the heme iron atom is oxidized was decreased by only 38%, indicating that this oxidized side-chain group is not tightly coupled to the ferryl peroxidase heme iron.	Iron	258-262	cytochrome c, somatic	Equus caballus	47-59
1794978-5	1991	In addition, the interaction of external ligands with the P450 heme iron was profoundly inhibited both in the oxidized and reduced forms.	Iron	68-72	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	58-62
3032307-6	1987	In contrast, the deficit in MPO activity was not corrected until 7 days after initiation of iron treatment.	Iron	92-96	myeloperoxidase	Rattus norvegicus	28-31
3032307-7	1987	The pattern of recovery in MPO activity after iron treatment corresponded to the prolonged period of maturation of the PMN primary granule since the formation of primary granules, which contain MPO, takes place only in the early, mitotic stages of maturation.	Iron	46-50	myeloperoxidase	Rattus norvegicus	27-30
3032307-7	1987	The pattern of recovery in MPO activity after iron treatment corresponded to the prolonged period of maturation of the PMN primary granule since the formation of primary granules, which contain MPO, takes place only in the early, mitotic stages of maturation.	Iron	46-50	myeloperoxidase	Rattus norvegicus	194-197
1794978-6	1991	These findings suggest that epsilon-amino nitrogen of Lys-301, which was introduced by amino acid substitution, occupies the 6th coordination position with the heme iron of the Lys-mutated P450, because, owing to conformation of the P450 protein, the epsilon-amino group may be located at just the right position for coordination as the internal 6th ligand.	Iron	165-169	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	189-193
1794978-6	1991	These findings suggest that epsilon-amino nitrogen of Lys-301, which was introduced by amino acid substitution, occupies the 6th coordination position with the heme iron of the Lys-mutated P450, because, owing to conformation of the P450 protein, the epsilon-amino group may be located at just the right position for coordination as the internal 6th ligand.	Iron	165-169	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	233-237
1657998-12	1991	These results indicate that mature size iron-sulfur apoprotein, lacking iron-sulfur cluster, is inserted into the cytochrome bc1 complex, where it interacts with and preserves the optical properties of cytochrome b.	Iron	40-44	cytochrome b	Saccharomyces cerevisiae S288C	114-126
3600643-5	1987	We have identified a sequence of 22 highly conserved nucleotides in the 5" untranslated sequences of chicken, human, and tadpole ferritin H-subunit genes and propose that this conserved sequence may regulate iron-modulated translation of ferritin H-subunit mRNAs.	Iron	208-212	ferritin heavy chain 1	Homo sapiens	129-147
3600643-5	1987	We have identified a sequence of 22 highly conserved nucleotides in the 5" untranslated sequences of chicken, human, and tadpole ferritin H-subunit genes and propose that this conserved sequence may regulate iron-modulated translation of ferritin H-subunit mRNAs.	Iron	208-212	ferritin heavy chain 1	Homo sapiens	238-256
1941194-6	1991	Rats were subsequently injected intraperitoneally with GM (50 or 100 mg.kg body wt-1.d-1) or saline for 8 d. High dietary iron resulted in greater sensitivity to GM (100 mg/kg body wt) toxicity in terms of elevated urinary excretion of n-acetyl-beta-glucosaminidase (NAG) and increased mineralization, casts and megalocytes in renal tubules.	Iron	122-126	O-GlcNAcase	Rattus norvegicus	236-265
2437773-5	1987	BF (DEAE-peak 1) and the iron binding proteins transferrin and lactoferrin (LF) are shown to inhibit the histamine release in vitro.	Iron	25-29	lactotransferrin	Rattus norvegicus	63-74
2437773-5	1987	BF (DEAE-peak 1) and the iron binding proteins transferrin and lactoferrin (LF) are shown to inhibit the histamine release in vitro.	Iron	25-29	lactotransferrin	Rattus norvegicus	76-78
3025217-2	1987	The effect of the purple acid phosphatases with binuclear iron centers (uteroferrin and bovine spleen phosphatase) on hydroxyl radical formation by iron-catalyzed Haber-Weiss-Fenton chemistry has been compared to that of lactoferrin and transferrin.	Iron	148-152	lactotransferrin	Bos taurus	221-232
1941194-6	1991	Rats were subsequently injected intraperitoneally with GM (50 or 100 mg.kg body wt-1.d-1) or saline for 8 d. High dietary iron resulted in greater sensitivity to GM (100 mg/kg body wt) toxicity in terms of elevated urinary excretion of n-acetyl-beta-glucosaminidase (NAG) and increased mineralization, casts and megalocytes in renal tubules.	Iron	122-126	O-GlcNAcase	Rattus norvegicus	267-270
1771037-1	1991	Transferrin receptor expression in the placenta may be regulated by the level of transferrin iron in maternal serum.	Iron	93-97	transferrin receptor	Homo sapiens	0-20
3492923-2	1987	We studied the role of granulocytes and lactoferrin (LF) in endotoxin and murine interleukin 1 (IL-1)-induced depression of serum Fe and Zn concentrations in both rabbits and rats.	Iron	130-132	lactotransferrin	Mus musculus	53-55
1939064-1	1991	Bovine heart microsomes have been found to contain a non-heme iron protein which serves as an electron acceptor for NADPH-cytochrome P-450 reductase and therefore stimulates NADPH oxidation.	Iron	62-66	cytochrome p450 oxidoreductase	Bos taurus	116-148
15221702-5	1987	The percent saturation of transferrin with iron increased from 33 +/- 6% on Day 0 to a maximum of 71 +/- 9% on Day 3.	Iron	43-47	inhibitor of carbonic anhydrase	Canis lupus familiaris	26-37
1791469-0	1991	On the interaction of phosvitins with ferric ion: solubility of the Fe(III)-phosphoprotein complex under acidic conditions is a function of the iron/phosphate ratio and the degree of phosvitin phosphorylation.	Iron	144-148	casein kinase 2 beta	Homo sapiens	22-31
3002171-1	1985	Transport of iron across the cell membrane is mediated by the iron-binding serum protein, transferrin, and its cell-surface receptor.	Iron	13-17	CD177 molecule	Homo sapiens	111-132
1791469-4	1991	At Fe/P ratios above 0.5, the Fe(III)-phosvitin complex becomes increasingly soluble.	Iron	3-5	casein kinase 2 beta	Homo sapiens	38-47
1791469-8	1991	The results imply that phosvitin iron binding sites are non-uniform and that, overall, phosvitin is capable of accommodating iron in different ways, depending on the relative magnitude of the iron load and the availability of phosphoserine clusters in the phosphoprotein.	Iron	33-37	casein kinase 2 beta	Homo sapiens	23-32
1791469-8	1991	The results imply that phosvitin iron binding sites are non-uniform and that, overall, phosvitin is capable of accommodating iron in different ways, depending on the relative magnitude of the iron load and the availability of phosphoserine clusters in the phosphoprotein.	Iron	125-129	casein kinase 2 beta	Homo sapiens	87-96
3849315-6	1985	The hypothesis is advanced that the systemic metabolic defect (tissue hypoxia, raised erythropoietin levels) produced by 1 alpha, 25-dihydroxycholecalciferol is responsible for the disruption of the physiological coordination between iron stores and intestinal absorption.	Iron	234-238	erythropoietin	Rattus norvegicus	86-100
1791469-8	1991	The results imply that phosvitin iron binding sites are non-uniform and that, overall, phosvitin is capable of accommodating iron in different ways, depending on the relative magnitude of the iron load and the availability of phosphoserine clusters in the phosphoprotein.	Iron	125-129	casein kinase 2 beta	Homo sapiens	87-96
2050126-3	1991	Iron starvation of cells induces high affinity binding of the cytoplasmic IRE-BP to an IRE which has at least two different known biological consequences, repression of ferritin mRNA translation and stabilization of the transferrin receptor transcript.	Iron	0-4	aconitase 1	Homo sapiens	74-80
2039550-8	1991	These experiments show that a haem precursor is involved in iron-dependent inactivation of UROD.	Iron	60-64	uroporphyrinogen decarboxylase	Mus musculus	91-95
4009165-4	1985	It is suggested that the inhibitory activity of ceruloplasmin mainly depends on the ferroxidase activity and that of transferrin is probably due to iron binding property.	Iron	148-152	ceruloplasmin	Homo sapiens	48-61
1890732-3	1991	Both Tf and TfR are reutilizable and have roles for the efficient intracellular accumulation of iron.	Iron	96-100	transferrin receptor	Homo sapiens	12-15
2982843-0	1985	Iron deposition in apoferritin.	Iron	0-4	ferritin heavy chain 1	Homo sapiens	19-30
2982843-2	1985	A preliminary EPR investigation of iron accumulation in apoferritin has identified paramagnetic species generated during the early stage of iron deposition within the apoprotein shell.	Iron	35-39	ferritin heavy chain 1	Homo sapiens	56-67
2982843-2	1985	A preliminary EPR investigation of iron accumulation in apoferritin has identified paramagnetic species generated during the early stage of iron deposition within the apoprotein shell.	Iron	140-144	ferritin heavy chain 1	Homo sapiens	56-67
1890732-4	1991	In addition to the reutilization (recycling), the expression of TfR is also regulated by cytoplasmic iron concentration; the increase of iron downregulate the synthesis of TfR at the translational level and vice versa.	Iron	101-105	transferrin receptor	Homo sapiens	64-67
1890732-4	1991	In addition to the reutilization (recycling), the expression of TfR is also regulated by cytoplasmic iron concentration; the increase of iron downregulate the synthesis of TfR at the translational level and vice versa.	Iron	101-105	transferrin receptor	Homo sapiens	172-175
2982408-1	1985	Iron-saturated chicken ovotransferrin was chemically oxidized with NaIO4, converting 50% of its methionine residues to their sulfoxide derivatives while maintaining 95% of its iron-binding activity.	Iron	0-4	transferrin (ovotransferrin)	Gallus gallus	23-37
1890732-4	1991	In addition to the reutilization (recycling), the expression of TfR is also regulated by cytoplasmic iron concentration; the increase of iron downregulate the synthesis of TfR at the translational level and vice versa.	Iron	137-141	transferrin receptor	Homo sapiens	64-67
2982408-1	1985	Iron-saturated chicken ovotransferrin was chemically oxidized with NaIO4, converting 50% of its methionine residues to their sulfoxide derivatives while maintaining 95% of its iron-binding activity.	Iron	176-180	transferrin (ovotransferrin)	Gallus gallus	23-37
2982408-2	1985	The oxidized chicken ovotransferrin was able to deliver iron to the chicken embryo red blood cell for heme synthesis.	Iron	56-60	transferrin (ovotransferrin)	Gallus gallus	21-35
1890732-4	1991	In addition to the reutilization (recycling), the expression of TfR is also regulated by cytoplasmic iron concentration; the increase of iron downregulate the synthesis of TfR at the translational level and vice versa.	Iron	137-141	transferrin receptor	Homo sapiens	172-175
2982408-4	1985	65% as efficient as unmodified diferric chicken ovotransferrin at competing with diferric (55Fe2) chicken ovotransferrin for the iron-donating sites of the chicken embryo red blood cells.	Iron	129-133	transferrin (ovotransferrin)	Gallus gallus	48-62
1890732-5	1991	This mechanism was recently explained by the binding between "iron responsive element (IRE)" in the 5" end of TfR mRNA and IRE binding protein by a transacting manner.	Iron	62-66	transferrin receptor	Homo sapiens	110-113
2982408-4	1985	65% as efficient as unmodified diferric chicken ovotransferrin at competing with diferric (55Fe2) chicken ovotransferrin for the iron-donating sites of the chicken embryo red blood cells.	Iron	129-133	transferrin (ovotransferrin)	Gallus gallus	106-120
2040285-9	1991	The fluorescence data obtained for apomyoglobin, myoglobin and the complex between protoporphyrin IX and apomyoglobin enable one to compare their structures and to evaluate the role of the porphyrin macrocycle and the iron atom in the formation of the native myoglobin structure and its functioning.	Iron	218-222	myoglobin	Physeter catodon	38-47
2040285-9	1991	The fluorescence data obtained for apomyoglobin, myoglobin and the complex between protoporphyrin IX and apomyoglobin enable one to compare their structures and to evaluate the role of the porphyrin macrocycle and the iron atom in the formation of the native myoglobin structure and its functioning.	Iron	218-222	myoglobin	Physeter catodon	49-58
1903202-1	1991	Iron-responsive elements (IREs) are regulatory RNA elements which serve as specific binding sites for the IRE-binding protein (IRE-BP).	Iron	0-4	aconitase 1	Homo sapiens	106-125
4090918-0	1985	[Secretin and pancreatic secretion in iron absorption].	Iron	38-42	SCT	Canis lupus familiaris	1-9
4090918-7	1985	A possible inhibitory effect of secretin on iron absorption was observed.	Iron	44-48	SCT	Canis lupus familiaris	32-40
4043001-0	1985	Determination of the second order doppler shift of iron in myoglobin by Mossbauer spectroscopy.	Iron	51-55	myoglobin	Homo sapiens	59-68
1903202-1	1991	Iron-responsive elements (IREs) are regulatory RNA elements which serve as specific binding sites for the IRE-binding protein (IRE-BP).	Iron	0-4	aconitase 1	Homo sapiens	127-133
4070674-6	1985	In iron storage diseases, MRI can detect early changes by its higher sensitivity to iron than that of X-CT.	Iron	3-7	solute carrier family 7 member 11	Homo sapiens	102-106
2015269-0	1991	Effect of metabolic inhibitors on uptake of non-transferrin-bound iron by reticulocytes.	Iron	66-70	serotransferrin	Oryctolagus cuniculus	48-59
6096143-2	1984	The results show that the replacement of the distal histidine of the hemoglobin beta chains by an arginine greatly enhances the susceptibility of the heme-iron to oxidative challenge.	Iron	155-159	hemoglobin subunit beta	Homo sapiens	69-84
2015269-1	1991	The relationship between transferrin-free iron uptake and cellular metabolism was investigated using rabbit reticulocytes in which energy metabolism was altered by incubation with metabolic inhibitors (antimycin A, 2,4-dinitrophenol, NaCN, NaN3 and rotenone) or substrates.	Iron	42-46	serotransferrin	Oryctolagus cuniculus	25-36
2015269-6	1991	It is concluded that the uptake of transferrin-free iron by reticulocytes is dependent on the cellular concentration of ATP and that it crosses the cell membrane by an active, carrier-mediated transport process.	Iron	52-56	serotransferrin	Oryctolagus cuniculus	35-46
2015269-7	1991	Additional studies were performed using transferrin-bound iron.	Iron	58-62	serotransferrin	Oryctolagus cuniculus	40-51
2015269-8	1991	The metabolic inhibitors also reduced the uptake of this form of iron but the inhibition could be accounted for entirely by reduction in the rate of transferrin endocytosis.	Iron	65-69	serotransferrin	Oryctolagus cuniculus	149-160
1824950-7	1991	The demonstration of a siderophore-like activity in supernates of iron-deficient legionella cultures may account for the ability of Legionella spp.	Iron	66-70	histocompatibility minor 13	Homo sapiens	143-146
6527986-6	1984	The results of the present study indicate that after the ferric iron is liberated from maternal haemoglobin its ionic state, subcellular distribution and, probably, its route of transport seem to be similar to that in the guinea-pig placenta which is characterized by the uptake of iron from maternal transferrin.	Iron	64-68	inhibitor of carbonic anhydrase	Cavia porcellus	301-312
1801846-10	1991	Dietary factors affect intestinal P450s markedly--iron restriction rapidly decreased intestinal P450 to beneath detectable values; selenium deficiency acted similarly but was less effective; Brussels sprouts increased intestinal AHH activity 9.8-fold, ECOD activity 3.2-fold, and P450 1.9-fold; fried meat and dietary fat significantly increased intestinal EROD activity; a vitamin A-deficient diet increased, and a vitamin A-rich diet decreased intestinal P450 activities; and excess cholesterol in the diet increased intestinal P450 activity.	Iron	50-54	aryl hydrocarbon receptor repressor	Homo sapiens	229-232
6477639-0	1984	Changes in the activity of gamma-amino butyric acid transaminase and succinic semialdehyde dehydrogenase in the cobalt and iron experimental epileptogenic foci in the rat brain.	Iron	123-127	aldehyde dehydrogenase 5 family, member A1	Rattus norvegicus	69-104
1770220-6	1991	Finally, the expression of CD71 receptor was increased by deferoxamine supplementation, this suggesting a partial involvement of iron overload in the depressed function.	Iron	129-133	transferrin receptor	Homo sapiens	27-31
6429041-1	1984	The role of ceruloplasmin (ferroxidase I; EC 1.16.3.1) in iron metabolism during experimental Neisseria meningitidis infection was investigated.	Iron	58-62	ceruloplasmin	Mus musculus	12-25
6429041-2	1984	Plasma ceruloplasmin activity was found to increase greatly in mice during the convalescence phase of iron-controlled infection and after a plasma hypoferremia had occurred.	Iron	102-106	ceruloplasmin	Mus musculus	7-20
6429041-3	1984	Ceruloplasmin activity-deficient animals became hypoferremic as a result of an impaired release of iron from the reticuloendothelial system as shown by impaired return of reticuloendothelial system-processed heme iron in these mice.	Iron	99-103	ceruloplasmin	Mus musculus	0-13
6429041-3	1984	Ceruloplasmin activity-deficient animals became hypoferremic as a result of an impaired release of iron from the reticuloendothelial system as shown by impaired return of reticuloendothelial system-processed heme iron in these mice.	Iron	213-217	ceruloplasmin	Mus musculus	0-13
6429041-4	1984	Hypoferremia in ceruloplasmin activity-deficient mice was associated with an increased resistance to N. meningitidis infection, an effect reversed readily by ceruloplasmin supplementation or iron addition.	Iron	191-195	ceruloplasmin	Mus musculus	16-29
6429041-5	1984	This evidence implicated ceruloplasmin activity as an important component in the regulation of the plasma transferrin iron pool and suggested that an important role of additional ceruloplasmin as an acute-phase protein might be related to the requirement of additional transferrin iron.	Iron	118-122	ceruloplasmin	Mus musculus	25-38
6429041-5	1984	This evidence implicated ceruloplasmin activity as an important component in the regulation of the plasma transferrin iron pool and suggested that an important role of additional ceruloplasmin as an acute-phase protein might be related to the requirement of additional transferrin iron.	Iron	281-285	ceruloplasmin	Mus musculus	25-38
2380200-1	1990	To investigate the regulation mechanism of the uptake of iron and heme iron by the cells and intracellular utilization of iron, we examined the interaction between iron uptake from transferrin and hemopexin-mediated uptake of heme by human leukemic U937 cells or HeLa cells.	Iron	57-61	hemopexin	Homo sapiens	197-206
6429041-5	1984	This evidence implicated ceruloplasmin activity as an important component in the regulation of the plasma transferrin iron pool and suggested that an important role of additional ceruloplasmin as an acute-phase protein might be related to the requirement of additional transferrin iron.	Iron	281-285	ceruloplasmin	Mus musculus	179-192
2380200-4	1990	Treatment of both species of cells with hemopexin led to a rapid decrease in iron uptake from transferrin in a hemopexin dose-dependent manner, and the decrease seen in case of treatment with hemin was less than that seen with hemopexin.	Iron	77-81	hemopexin	Homo sapiens	40-49
2380200-4	1990	Treatment of both species of cells with hemopexin led to a rapid decrease in iron uptake from transferrin in a hemopexin dose-dependent manner, and the decrease seen in case of treatment with hemin was less than that seen with hemopexin.	Iron	77-81	hemopexin	Homo sapiens	111-120
6327700-1	1984	Removal of the heme iron from cytochrome c to generate porphyrin cytochrome c relieves the quenching of porphyrin fluorescence and enhances the fluorescence of the single tryptophan residue and the 4 tyrosine residues.	Iron	20-24	cytochrome c, somatic	Equus caballus	30-42
6327700-1	1984	Removal of the heme iron from cytochrome c to generate porphyrin cytochrome c relieves the quenching of porphyrin fluorescence and enhances the fluorescence of the single tryptophan residue and the 4 tyrosine residues.	Iron	20-24	cytochrome c, somatic	Equus caballus	65-77
2380200-4	1990	Treatment of both species of cells with hemopexin led to a rapid decrease in iron uptake from transferrin in a hemopexin dose-dependent manner, and the decrease seen in case of treatment with hemin was less than that seen with hemopexin.	Iron	77-81	hemopexin	Homo sapiens	111-120
6327680-6	1984	In iron-depleted systems containing cytochrome P-450 LM2 or cytochrome P-450 LMeb , an appropriate stoichiometry was attained between the NADPH consumed and the sum of hydrogen peroxide and acetaldehyde produced.	Iron	3-7	cytochrome P450 2B4	Oryctolagus cuniculus	36-56
2380200-5	1990	The decrease of iron uptake by hemopexin contributed to a decrease in cell surface transferrin receptors on hemopexin-treated cells.	Iron	16-20	hemopexin	Homo sapiens	31-40
2380200-5	1990	The decrease of iron uptake by hemopexin contributed to a decrease in cell surface transferrin receptors on hemopexin-treated cells.	Iron	16-20	hemopexin	Homo sapiens	108-117
6705203-0	1984	Diluent in the technicon SMAC assay for iron modified to avoid serum precipitation.	Iron	40-44	diablo IAP-binding mitochondrial protein	Homo sapiens	25-29
2376574-1	1990	Hemin at greater than 1 microM concentrations inhibits the interaction of the iron responsive element (IRE) and the iron responsive element binding protein (IRE-BP) as measured by gel retardation and UV cross-linking.	Iron	78-82	aconitase 1	Homo sapiens	116-155
2376574-1	1990	Hemin at greater than 1 microM concentrations inhibits the interaction of the iron responsive element (IRE) and the iron responsive element binding protein (IRE-BP) as measured by gel retardation and UV cross-linking.	Iron	78-82	aconitase 1	Homo sapiens	157-163
6717804-6	1984	The overlapping distribution patterns of iron and gamma-aminobutyric acid, enkephalin, and luteinizing hormone-releasing hormone suggest that the distribution of iron is related to its association with the metabolism of one or more neurotransmitters or neuroactive compounds.	Iron	162-166	proenkephalin	Rattus norvegicus	75-85
2386009-8	1990	Serum isoferritin profiles by isoelectric focussing were studied, and isoferritin pattern from malignant histiocytosis was the same as that in iron overloading after neuraminidase treatment.	Iron	143-147	neuraminidase 1	Homo sapiens	166-179
6717804-6	1984	The overlapping distribution patterns of iron and gamma-aminobutyric acid, enkephalin, and luteinizing hormone-releasing hormone suggest that the distribution of iron is related to its association with the metabolism of one or more neurotransmitters or neuroactive compounds.	Iron	162-166	gonadotropin releasing hormone 1	Rattus norvegicus	91-128
6319414-0	1984	Physiological levels of binding and iron donation by complementary half-molecules of ovotransferrin to transferrin receptors of chick reticulocytes.	Iron	36-40	transferrin (ovotransferrin)	Gallus gallus	85-99
2108730-1	1990	A recently developed technique combining urea gel electrophoresis with Western immunoblotting has been modified for assessing the relative ability of each iron binding site of rabbit transferrin in delivering iron to rabbit reticulocytes.	Iron	155-159	serotransferrin	Oryctolagus cuniculus	183-194
2108730-1	1990	A recently developed technique combining urea gel electrophoresis with Western immunoblotting has been modified for assessing the relative ability of each iron binding site of rabbit transferrin in delivering iron to rabbit reticulocytes.	Iron	209-213	serotransferrin	Oryctolagus cuniculus	183-194
2108730-8	1990	Thus, the transferrin-reticulocyte interaction is sensitive to environmental variables, and such sensitivity may help account for apparent discrepancies in previous studies of the relative iron-donating abilities of the two sites of transferrin.	Iron	66-70	serotransferrin	Oryctolagus cuniculus	10-21
2317515-4	1990	The magnitude of the circular dichroism of bigeye tuna myoglobin at 222 nm was comparable to that of sperm whale myoglobin, but its hydropathy profile revealed the region corresponding to the distal side of the heme iron to be apparently less hydrophobic.	Iron	216-220	myoglobin	Physeter catodon	55-64
6696745-10	1984	These data suggested that H2S produced from cysteine by some vitamin B6-dependent enzyme(s) converted cytosolic and microsomal iron into a reactive loosely bound form that inactivated ODC.	Iron	127-131	ornithine decarboxylase 1	Rattus norvegicus	184-187
33942901-4	2021	Considering the central role of the TMPRSS6/HJV/hepcidin axis in iron homeostasis, the inhibition of TMPRSS6 expression represents a promising therapeutic strategy to increase hepcidin production and ameliorate anaemia and iron overload in beta-thalassaemia.	Iron	223-227	transmembrane serine protease 6	Mus musculus	101-108
6202140-2	1984	BSC are inclusions of aggregated ribosomes found only in the red blood cells and may be confused with siderotic (iron) granules.	Iron	113-117	solute carrier family 12 member 2	Homo sapiens	0-3
33940654-6	2022	Furthermore, the addition of ferric chloride (FeCl3) to plasma propagated thrombin generation in a FVIII and FIX-dependent manner suggesting that iron positively affects blood coagulation.	Iron	146-150	coagulation factor VIII	Homo sapiens	99-104
6326658-3	1984	The gene for TF therefore maps to the same region as the gene for transferrin receptor (TFR) thereby defining an iron transport region on 3q2 to which the transferrin-related tumor associated antigen p97 may also belong.	Iron	113-117	melanotransferrin	Homo sapiens	200-203
33774058-11	2021	CONCLUSIONS: Variants in non-HFE iron genes, particularly Ceruloplasmin, are associated with hyperferritinemia and increased hepatic iron stores in patients with NAFLD.	Iron	33-37	homeostatic iron regulator	Homo sapiens	29-32
6434227-3	1984	Metal analyses showed that lactoferrin of bovine milk contained the highest amount of iron while lactoferrin of human milk and human pancreatic juice were similar in content of iron, approximately four-fold lower than bovine milk.	Iron	86-90	lactotransferrin	Bos taurus	27-38
6434227-3	1984	Metal analyses showed that lactoferrin of bovine milk contained the highest amount of iron while lactoferrin of human milk and human pancreatic juice were similar in content of iron, approximately four-fold lower than bovine milk.	Iron	177-181	lactotransferrin	Bos taurus	97-108
6709830-1	1984	In experiments on SHK mice it was shown that a single administration of highly-dispersed iron powder (0.2 to 100 mg/kg body weight) 20-30 min before irradiation with different doses exerted both a radioprotective and an enhancing effect and depended on both a radiation dose and a concentration of the iron powder administered.	Iron	89-93	sedoheptulokinase	Mus musculus	18-21
33774058-11	2021	CONCLUSIONS: Variants in non-HFE iron genes, particularly Ceruloplasmin, are associated with hyperferritinemia and increased hepatic iron stores in patients with NAFLD.	Iron	133-137	homeostatic iron regulator	Homo sapiens	29-32
33033759-2	2020	Previously, we found that iron-depletion downregulated the expression of proteins, arginine methyltransferase-1 and 3 (PRMT1 and PRMT3), by an iron-specific chelator, deferoxamine (DFO), in rat liver FAO cell line using DNA microarray analysis (unpublished data).	Iron	26-30	protein arginine methyltransferase 1	Rattus norvegicus	119-124
6644450-0	1983	Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron.	Iron	29-33	lactotransferrin	Mus musculus	43-54
6644450-1	1983	Lactoferrin is an iron-binding protein present in high concentrations in human milk.	Iron	18-22	lactotransferrin	Mus musculus	0-11
6644450-2	1983	The efficacy of supplementing iron bound to lactoferrin to iron-deficient and iron-sufficient young mice was evaluated in comparison with supplementation of iron as iron chloride.	Iron	59-63	lactotransferrin	Mus musculus	44-55
6644450-2	1983	The efficacy of supplementing iron bound to lactoferrin to iron-deficient and iron-sufficient young mice was evaluated in comparison with supplementation of iron as iron chloride.	Iron	59-63	lactotransferrin	Mus musculus	44-55
6644450-2	1983	The efficacy of supplementing iron bound to lactoferrin to iron-deficient and iron-sufficient young mice was evaluated in comparison with supplementation of iron as iron chloride.	Iron	59-63	lactotransferrin	Mus musculus	44-55
6644450-4	1983	Iron supplementation of the diet with lactoferrin-iron, or iron chloride at a level of 5 mg Fe/L prevented the anemia and resulted in tissue iron levels similar to levels found for mice fed a stock commercial diet.	Iron	0-4	lactotransferrin	Mus musculus	38-49
6644450-4	1983	Iron supplementation of the diet with lactoferrin-iron, or iron chloride at a level of 5 mg Fe/L prevented the anemia and resulted in tissue iron levels similar to levels found for mice fed a stock commercial diet.	Iron	50-54	lactotransferrin	Mus musculus	38-49
33033759-2	2020	Previously, we found that iron-depletion downregulated the expression of proteins, arginine methyltransferase-1 and 3 (PRMT1 and PRMT3), by an iron-specific chelator, deferoxamine (DFO), in rat liver FAO cell line using DNA microarray analysis (unpublished data).	Iron	143-147	protein arginine methyltransferase 1	Rattus norvegicus	119-124
33033759-4	2020	In the present study, we revealed that the treatment of cells with two iron-specific chelators, DFO and deferasirox (DFX), downregulated the gene and protein expression of PRMT1 and 3 as compared with the untreated cells.	Iron	71-75	protein arginine methyltransferase 1	Rattus norvegicus	172-183
26319559-2	2016	In response to hypoxia, in the PWM, there was increased expression of proteins involved in iron acquisition, such as iron regulatory proteins (IRP1, IRP2) and transferrin receptor in oligodendrocytes.	Iron	91-95	aconitase 1	Homo sapiens	143-147
6416253-0	1983	The incorporation of iron into apoferritin as mediated by ceruloplasmin.	Iron	21-25	ferritin heavy chain 1	Homo sapiens	31-42
6416253-0	1983	The incorporation of iron into apoferritin as mediated by ceruloplasmin.	Iron	21-25	ceruloplasmin	Homo sapiens	58-71
26319559-2	2016	In response to hypoxia, in the PWM, there was increased expression of proteins involved in iron acquisition, such as iron regulatory proteins (IRP1, IRP2) and transferrin receptor in oligodendrocytes.	Iron	117-121	aconitase 1	Homo sapiens	143-147
6416253-1	1983	Ceruloplasmin, a copper ferroxidase, promotes the incorporation of Fe(III) into the iron storage protein, apoferritin.	Iron	84-88	ceruloplasmin	Homo sapiens	0-13
6416253-1	1983	Ceruloplasmin, a copper ferroxidase, promotes the incorporation of Fe(III) into the iron storage protein, apoferritin.	Iron	84-88	ferritin heavy chain 1	Homo sapiens	106-117
26319559-4	2016	The increased concentration of iron within hypoxic oligodendrocytes was found to elicit ryanodine receptor (RyR) expression, and the expression of endoplasmic reticulum (ER) stress markers such as binding-immunoglobulin protein (BiP) and inositol-requiring enzyme (IRE)-1alpha.	Iron	31-35	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	238-276
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	42-46	aconitase 1	Homo sapiens	69-73
6416253-6	1983	These data support a more specific role for ceruloplasmin in iron metabolism than has previously been proposed.	Iron	61-65	ceruloplasmin	Homo sapiens	44-57
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	108-112	aconitase 1	Homo sapiens	42-67
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	108-112	aconitase 1	Homo sapiens	69-73
6882688-3	1983	Up to 70% of the iron taken up by the cells was utilized in haem synthesis and competed directly with iron derived from transferrin.	Iron	17-21	inhibitor of carbonic anhydrase	Cavia porcellus	120-131
6882688-3	1983	Up to 70% of the iron taken up by the cells was utilized in haem synthesis and competed directly with iron derived from transferrin.	Iron	102-106	inhibitor of carbonic anhydrase	Cavia porcellus	120-131
26560363-5	2015	In addition, in response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells.	Iron	110-114	transferrin receptor	Homo sapiens	72-92
6882688-8	1983	The endocytotic vesicle fuses with a lysosome, iron is removed from the protein and enters a cytosolic pool in which it competes directly with transferrin-derived iron to provide iron for mitochondrial haem synthesis.	Iron	163-167	inhibitor of carbonic anhydrase	Cavia porcellus	143-154
6882688-8	1983	The endocytotic vesicle fuses with a lysosome, iron is removed from the protein and enters a cytosolic pool in which it competes directly with transferrin-derived iron to provide iron for mitochondrial haem synthesis.	Iron	163-167	inhibitor of carbonic anhydrase	Cavia porcellus	143-154
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	217-221	transmembrane serine protease 6	Mus musculus	13-45
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	217-221	transmembrane serine protease 6	Mus musculus	47-54
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	217-221	transmembrane serine protease 6	Mus musculus	68-80
6636637-4	1983	Intake of vitamins in conjunction with iron, copper and manganese was followed by a more pronounced increase, as compared with the "vitamin" and especially with the control groups, in hemoglobin, red cell count, ceruloplasmin activity and by the increment of trace elements in the blood in the presence of high retention of iron and manganese in the body.	Iron	39-43	ceruloplasmin	Homo sapiens	212-225
25687342-0	2015	The Study of HFE Genotypes and Its Expression Effect on Iron Status of Iranian Haemochromatosis, Iron Deficiency Anemia Patients, Iron-Taker and Non Iron-Taker Controls.	Iron	56-60	homeostatic iron regulator	Homo sapiens	13-16
6649053-2	1983	RBC count, Hb, serum iron and iron binding capacity were significantly lower in male and female students at Dead Sea level than at Amman.	Iron	30-34	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	113-116
25687342-0	2015	The Study of HFE Genotypes and Its Expression Effect on Iron Status of Iranian Haemochromatosis, Iron Deficiency Anemia Patients, Iron-Taker and Non Iron-Taker Controls.	Iron	97-101	homeostatic iron regulator	Homo sapiens	13-16
25687342-0	2015	The Study of HFE Genotypes and Its Expression Effect on Iron Status of Iranian Haemochromatosis, Iron Deficiency Anemia Patients, Iron-Taker and Non Iron-Taker Controls.	Iron	97-101	homeostatic iron regulator	Homo sapiens	13-16
6297596-1	1983	The 1H-NMR lines of heme c and the axial ligands in reduced and oxidized Iso-1 and Iso-2 cytochromes c from Saccharomyces cerevisiae and in cytochrome c from Candida krusei were individually assigned and the conformation of the coordination sphere of the heme iron was investigated with the use of proton-proton Overhauser enhancement measurements and circular dichroism spectroscopy.	Iron	260-264	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	73-78
25687342-1	2015	The role of HFE gene mutations or its expression in regulation of iron metabolism of hereditary haemochromatosis (HH) patients is remained controversial.	Iron	66-70	homeostatic iron regulator	Homo sapiens	12-15
6418154-0	1983	Lipoxygenase from rabbit reticulocytes: iron content, amino acid composition and C-terminal heterogeneity.	Iron	40-44	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	0-12
6418154-1	1983	Purified lipoxygenase from rabbit reticulocytes contains 1 g atom iron per molecule.	Iron	66-70	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	9-21
25687342-2	2015	Therefore here the correlation between two common HFE genotype (p.C282Y, p.H63D) and HFE gene expression with iron status in HH, iron deficiency anemia (IDA) and healthy Iranian participants was studied.	Iron	110-114	homeostatic iron regulator	Homo sapiens	50-53
25687342-2	2015	Therefore here the correlation between two common HFE genotype (p.C282Y, p.H63D) and HFE gene expression with iron status in HH, iron deficiency anemia (IDA) and healthy Iranian participants was studied.	Iron	110-114	homeostatic iron regulator	Homo sapiens	85-88
12098643-2	2002	The HFE protein is an important regulator of cellular iron homeostasis and variations within this gene can result in iron overload and the disorder known as hereditary haemochromatosis.	Iron	54-58	homeostatic iron regulator	Homo sapiens	4-7
6277949-0	1982	The conformational transition of horse heart porphyrin c. The heme iron of horse heart cytochrome c was selectively removed using anhydrous HF.	Iron	67-71	cytochrome c, somatic	Equus caballus	87-99
12098643-2	2002	The HFE protein is an important regulator of cellular iron homeostasis and variations within this gene can result in iron overload and the disorder known as hereditary haemochromatosis.	Iron	117-121	homeostatic iron regulator	Homo sapiens	4-7
7198642-0	1982	Iron-dependent regulation of rat liver phenylalanine hydroxylase activity in vivo, in vitro, and in perfused liver.	Iron	0-4	phenylalanine hydroxylase	Rattus norvegicus	39-64
34461510-5	2022	A favourable reduction of pH and a betterment of parameters related to colour were detected in wines from iron deficient subzones.	Iron	106-110	phenylalanine hydroxylase	Homo sapiens	26-28
7318980-2	1981	It is a well recognized problem that sample derived transferrin-bound iron (Tf-Fe) interferes with radio-iron incorporation into heme in the in vitro assay of erythropoietin (Ep) using fetal mouse liver cells (FMLC).	Iron	70-74	erythropoietin	Mus musculus	159-173
7318980-2	1981	It is a well recognized problem that sample derived transferrin-bound iron (Tf-Fe) interferes with radio-iron incorporation into heme in the in vitro assay of erythropoietin (Ep) using fetal mouse liver cells (FMLC).	Iron	105-109	erythropoietin	Mus musculus	159-173
34823116-4	2022	In the mitochondria, Fe-S cluster assembly is accomplished through the coordinated activity of the ISC pathway protein complex composed of a cysteine desulfurase, a scaffold protein, the accessory ISD11 protein, the acyl carrier protein, frataxin, and a ferredoxin; downstream events that accomplish Fe-S cluster transfer and delivery are driven by additional chaperone/delivery proteins that interact with the ISC assembly complex.	Iron	21-25	frataxin	Homo sapiens	238-246
7319196-1	1981	Human ceruloplasmin was found to have a neutralizing effect against the toxohormone activities of the basic protein isolated from Ehrlich carcinoma cells; this basic protein decreases the levels of serum iron and liver catalase activity upon intraperitoneal injection into mice and shows direct cytotoxicity toward normal mouse lymphocytes and macrophages.	Iron	204-208	ceruloplasmin	Mus musculus	6-19
34969248-8	2022	For mice after intragastric poisoning with sarin (a neurotoxic agent), an atropine-assisted 2-PAM@MIL-88B(Fe) treatment experiment revealed that 2-PAM@MIL-88B(Fe) continuously released 2-PAM for more than 72 h so that poisoned AChE was continuously and steadily reactivated.	Iron	106-108	acetylcholinesterase	Mus musculus	227-231
6942404-1	1981	With the completion of the primary structure of the 50,000- and 19,000-dalton fragments of human ceruloplasmin [ferroxidase; iron(II):oxygen oxidoreductase, EC 1.16.3.1], over half of the covalent structure of the single polypeptide chain of this protein is known.	Iron	125-129	ceruloplasmin	Homo sapiens	97-110
34969248-8	2022	For mice after intragastric poisoning with sarin (a neurotoxic agent), an atropine-assisted 2-PAM@MIL-88B(Fe) treatment experiment revealed that 2-PAM@MIL-88B(Fe) continuously released 2-PAM for more than 72 h so that poisoned AChE was continuously and steadily reactivated.	Iron	159-161	acetylcholinesterase	Mus musculus	227-231
7225422-3	1981	Transferrin, the III-X component and the low molecular weight fraction are the first to accumulate radioactive iron during the reticulocyte incubation.	Iron	111-115	inhibitor of carbonic anhydrase	Cavia porcellus	0-11
34861512-4	2022	The in-situ gelatinized hydrogel, with outstanding photothermal effect and chemodynamic effect derived from the doped Fe in BGN-Fe-Ag2S, can not only eliminate multidrug-resistant bacteria but also efficiently ablated tumor during treatment.	Iron	118-120	angiotensin II receptor type 1	Homo sapiens	131-135
34861512-4	2022	The in-situ gelatinized hydrogel, with outstanding photothermal effect and chemodynamic effect derived from the doped Fe in BGN-Fe-Ag2S, can not only eliminate multidrug-resistant bacteria but also efficiently ablated tumor during treatment.	Iron	128-130	angiotensin II receptor type 1	Homo sapiens	131-135
34546653-2	2021	Here, we firstly introduce an iron-based NASICON-type Na 4 Fe 3 (PO 4 ) 2 (P 2 O 7 ) with carbon layer (NFPP@C) as cathode material for ZIBs.	Iron	30-34	ERC2 intronic transcript 1	Homo sapiens	54-82
6260144-1	1981	The electron-transfer mechanism of the Fe4S4 high-potential iron-sulfur proteins (HiPIP"s) was explored via a stopped-flow spectrophotometric kinetic study of the reduction of Chromatium vinosum and Rhodopseudomonas gelatinosa HiPIP"s by both native and trinitrophenyllysine-13 horse cytochrome c.	Iron	60-64	cytochrome c, somatic	Equus caballus	284-296
34914695-0	2021	Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.	Iron	118-122	leucine-rich repeat kinase 2	Mus musculus	13-18
6252957-3	1980	To further the understanding of biological electron transfer, we have investigated the interaction of two examples of high-potential iron-sulfur proteins (HIPIP"s) with mitochondrial cytochrome c (horse heart) and bacterial cytochrome c2 from Rhodospirillum rubrum, Rhodopseudomonas palustris, Rhodopseudomonas capsulata, and Rhodopseudomonas sphaeroides.	Iron	133-137	cytochrome c, somatic	Equus caballus	183-195
6251057-5	1980	The similarity between the EPR spectra of the NO complexes of horse heart cytochrome c and the heme d1-depleted Pseudomonas cytochrome oxidase before and after interaction with urea suggests structural similarities involving the heme irons.	Iron	234-239	cytochrome c, somatic	Equus caballus	74-86
34914695-9	2021	Our data support a role of LRRK2 in modulating iron uptake and storage in response to proinflammatory stimuli in microglia.	Iron	47-51	leucine-rich repeat kinase 2	Mus musculus	27-32
34890402-3	2021	Here we demonstrate that, by using the iron restrictive properties of the antisense oligonucleotides against Tmprss6 mRNA, we can increase hepcidin to achieve effects equivalent to therapeutic phlebotomy.	Iron	39-43	transmembrane serine protease 6	Mus musculus	109-116
314815-4	1979	Analysis of the iron-binding data for phosvitin suggested that clusters of di-O-phosphorylserine residues (SerP.SerP) were the most probable iron-binding sites.	Iron	16-20	casein kinase 2 beta	Bos taurus	38-47
314815-4	1979	Analysis of the iron-binding data for phosvitin suggested that clusters of di-O-phosphorylserine residues (SerP.SerP) were the most probable iron-binding sites.	Iron	141-145	casein kinase 2 beta	Bos taurus	38-47
18962513-1	1979	The band vector and representative-space transformation concept was applied to characterize the fine structure of FeL(alpha 1,2) (valence band) spectra of different iron compounds for their direct identification.	Iron	165-169	adrenoceptor alpha 1D	Homo sapiens	118-127
34959389-13	2021	The mRNAs encoding HTT, APP and alphaSYN contain an atypical iron response element (IRE) in their 5"-untranslated regions (5"-UTRs) that bind iron regulatory protein 1 (IRP1), and Posiphen specifically bound this complex.	Iron	61-65	huntingtin	Homo sapiens	19-22
708646-0	1978	Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport.	Iron	75-79	src-like adaptor	Mus musculus	35-38
708646-3	1978	The anaemia in newborn sla mice is attributable to iron deficiency, since their total body iron is lower than in normal newborn mice, while their birth weights are almost identical.	Iron	51-55	src-like adaptor	Mus musculus	23-26
708646-8	1978	The sla gene is already known to have a major effect in reducing iron transport in the small intestine.	Iron	65-69	src-like adaptor	Mus musculus	4-7
34959389-13	2021	The mRNAs encoding HTT, APP and alphaSYN contain an atypical iron response element (IRE) in their 5"-untranslated regions (5"-UTRs) that bind iron regulatory protein 1 (IRP1), and Posiphen specifically bound this complex.	Iron	61-65	aconitase 1	Homo sapiens	142-167
34959389-13	2021	The mRNAs encoding HTT, APP and alphaSYN contain an atypical iron response element (IRE) in their 5"-untranslated regions (5"-UTRs) that bind iron regulatory protein 1 (IRP1), and Posiphen specifically bound this complex.	Iron	61-65	aconitase 1	Homo sapiens	169-173
34871043-3	2022	Here, we demonstrate that mitochondrial calcium uptake 1 (MICU1)-deficient (MICU1-/-) neutrophils accumulate higher levels of calcium and iron within the mitochondria in a mitochondrial calcium uniporter (MCU)-dependent manner.	Iron	138-142	mitochondrial calcium uptake 1	Mus musculus	58-63
744164-4	1978	It is an iron-binding glycoprotein with a molecular weight by SDS gel electrophoresis equal to mouse, human and bovine lactoferrin.	Iron	9-13	lactotransferrin	Bos taurus	119-130
34871043-3	2022	Here, we demonstrate that mitochondrial calcium uptake 1 (MICU1)-deficient (MICU1-/-) neutrophils accumulate higher levels of calcium and iron within the mitochondria in a mitochondrial calcium uniporter (MCU)-dependent manner.	Iron	138-142	mitochondrial calcium uptake 1	Mus musculus	76-81
34861039-1	2022	SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes (MDS) with ring sideroblasts, a clonal hematopoietic disorder characterized by abnormal erythroid cells with iron-loaded mitochondria.	Iron	197-201	splicing factor 3b subunit 1	Homo sapiens	0-5
678672-3	1978	Investigations on the mouse fetal liver cell bioassay for erythropoietin (ESF) have revealed that iron present in test sera significantly dilutes the radiolabel (59Fe) and thus decreases 59Fe incorporation into heme.	Iron	98-102	erythropoietin	Mus musculus	58-72
34861039-2	2022	Despite this remarkably strong genotype-to-phenotype correlation, the mechanism by which mutant SF3B1 dysregulates iron metabolism to cause ring sideroblasts (RS) remains unclear due to an absence of physiological models of RS formation.	Iron	115-119	splicing factor 3b subunit 1	Homo sapiens	96-101
34861039-7	2022	Our study demonstrates that coordinated mis-splicing of mitochondrial transporters TMEM14C and ABCB7 by mutant SF3B1 sequesters iron in mitochondria, causing ring sideroblast formation.	Iron	128-132	splicing factor 3b subunit 1	Homo sapiens	111-116
740000-8	1978	The low temperature reduction of azide and cyanide complexes of myoglobin led to formation of nonequilibrium low spin ferroforms whose spectra demonstrate the presence of N3- and CN- in heme iron"s coordination sphere.	Iron	191-195	myoglobin	Homo sapiens	64-73
34925433-0	2021	Corrigendum: Involvement of Arabidopsis Multi-Copper Oxidase-Encoding LACCASE12 in Root-to-Shoot Iron Partitioning: A Novel Example of Copper-Iron Crosstalk.	Iron	142-146	laccase 12	Arabidopsis thaliana	70-79
34369274-12	2021	Moreover, TFRC activated PTEN induced kinase 1 (PINK1) signaling and induced mitophagy; iron-uptake-induced upregulation of acyl-CoA synthetase long chain family member 4 (ACSL4) was required for mitophagy activation and glutathione peroxidase 4 (GPX4) degradation.	Iron	88-92	transferrin receptor	Homo sapiens	10-14
638088-0	1978	Transferrin-bound iron and its effect on erythropoietin as measured by mouse fetal liver cell assay.	Iron	18-22	erythropoietin	Mus musculus	41-55
34369274-14	2021	In conclusion, TFRC increased the iron content, mediated the release of ROS, activated mitophagy, and induced lipid peroxidation, which further promoted the ferroptosis of KGN cells.	Iron	34-38	transferrin receptor	Homo sapiens	15-19
630743-3	1978	The rise of ceruloplasmin was associated with a continuous decline of total iron binding capacity.	Iron	76-80	ceruloplasmin	Homo sapiens	12-25
34340090-3	2021	Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT.	Iron	107-109	ferritin 4	Arabidopsis thaliana	19-24
630743-4	1978	The temporarily raised serum iron levels and the continuous decline of unsaturated iron binding capacity suggested enhanced iron mobilization caused by the raised ceruloplasmin level.	Iron	29-33	ceruloplasmin	Homo sapiens	163-176
34571345-9	2021	RP1-86C11.7 overexpression in glioma cells elevated TFRC expression, increased the intracellular free iron level, and deteriorated oncogenicity, with a significant reduction in hsa-miR-144-3p.	Iron	102-106	RP1 axonemal microtubule associated	Homo sapiens	0-3
874373-3	1977	Parenteral iron administration produced an increase in the duodenal, liver, and splenic ferritin concentration in both sla/Y and +/Y animals that was most striking in the case of the liver.	Iron	11-15	src-like adaptor	Mus musculus	119-122
874373-4	1977	Duodenal ferritin synthesis, both in vivo and in vitro, was increased in iron-deficient sla/Y animals and decreased in iron-deficient +/Y animals.	Iron	73-77	src-like adaptor	Mus musculus	88-91
874373-6	1977	In sla/Y animals fed an iron-deficient diet, duodenal ferritin synthesis decreased to near normal levels.	Iron	24-28	src-like adaptor	Mus musculus	3-6
34571345-11	2021	However, the effect of silencing RP1-86C11.7 was reversed with simultaneous hsa-miR-144-3p inhibitor treatment: the TFRC level, intracellular iron level and proliferation in glioma cells increased.	Iron	142-146	RP1 axonemal microtubule associated	Homo sapiens	33-36
34928835-5	2021	The kinetics study revealed that equilibrium was reached after 120 min for both metals, and maximal adsorbed quantities of cadmium (76 mg/g) and iron (55 mg/g ) were obtained at pH = 10 and 8 respectively.	Iron	145-149	phenylalanine hydroxylase	Homo sapiens	178-180
891665-6	1977	Both tritiated thymidine and iron incorporation were dependent on erythropoietin concentration.	Iron	29-33	erythropoietin	Mus musculus	66-80
34943874-3	2021	Therefore, the heme-based reactivity of Ngb is modulated by the dissociation of the distal HisE7-heme-Fe bond, which reflects in turn the redox state of the cell.	Iron	102-104	neuroglobin	Mus musculus	40-43
186315-0	1976	Iron binding to apoferritin: a fluorescence spectroscopy study.	Iron	0-4	ferritin heavy chain 1	Homo sapiens	16-27
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	180-184	SMAD family member 1	Homo sapiens	56-60
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	244-248	SMAD family member 1	Homo sapiens	56-60
239844-2	1975	Either total labeled iron uptake by the cells or hematin synthesis from labeled iron may be used as the measure of erythropoietin action.	Iron	80-84	erythropoietin	Rattus norvegicus	115-129
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	16-20	SMAD family member 1	Homo sapiens	58-65
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	16-20	SMAD family member 1	Homo sapiens	94-101
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	123-127	SMAD family member 1	Homo sapiens	94-101
34976359-4	2021	The as-prepared Cu/Cu x OF hybrid showed unusual catalytic activity towards the CO2RR for CH3COO- generation, with a high FE of 27% at extremely low potentials.	Iron	122-124	cut like homeobox 1	Homo sapiens	19-23
4436436-1	1974	Hemoglobin and myoglobin are a major source of dietary iron in man.	Iron	55-59	myoglobin	Homo sapiens	15-24
34618059-3	2021	Here, the use of grafts involving highly heterozygous apple (Malus) genotypes allowed us to demonstrate that apple (Malus domestica) oligopeptide transporter3 (MdOPT3) mRNA can be transported over a long distance, from the leaf to the root, to regulate iron uptake; however, the mRNA of Arabidopsis (Arabidopsis thaliana) oligopeptide transporter 3 (AtOPT3), the MdOPT3 homolog from A. thaliana, does not move from shoot to root.	Iron	253-257	oligopeptide transporter	Arabidopsis thaliana	350-356
4854920-10	1974	The molecule of phenylalanine hydroxylase contained two atoms of iron, one atom of copper and one molecule of FAD; molybdenum was absent.	Iron	65-69	phenylalanine hydroxylase	Rattus norvegicus	16-41
4855331-2	1974	The uptake and subsequent release of iron by apoferritin and ferritin was studied by using labelled iron ((59)Fe).	Iron	37-41	ferritin heavy chain 1	Homo sapiens	45-56
4855331-2	1974	The uptake and subsequent release of iron by apoferritin and ferritin was studied by using labelled iron ((59)Fe).	Iron	100-104	ferritin heavy chain 1	Homo sapiens	45-56
4855331-2	1974	The uptake and subsequent release of iron by apoferritin and ferritin was studied by using labelled iron ((59)Fe).	Iron	110-112	ferritin heavy chain 1	Homo sapiens	45-56
34716241-6	2021	The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis.	Iron	55-59	transferrin receptor	Mus musculus	71-75
4797166-3	1973	A study was made of the uptake of ferrous iron by apoferritin in the presence of an oxidizing agent at very low iron:protein ratios.	Iron	42-46	ferritin heavy chain 1	Homo sapiens	50-61
4797166-3	1973	A study was made of the uptake of ferrous iron by apoferritin in the presence of an oxidizing agent at very low iron:protein ratios.	Iron	112-116	ferritin heavy chain 1	Homo sapiens	50-61
4797166-4	1973	At ratios of less than about 150 iron atoms per apoferritin molecule hyperbolic progress curves were obtained, whereas at higher ratios the curves became sigmoidal under the conditions used.	Iron	33-37	ferritin heavy chain 1	Homo sapiens	48-59
34716241-6	2021	The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis.	Iron	55-59	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	77-81
4797166-6	1973	The experimental evidence indicates that apoferritin binds ferrous iron and catalyses the initial stage in the formation of the ferric oxide hydrate inside the protein shell.	Iron	59-71	ferritin heavy chain 1	Homo sapiens	41-52
34718778-0	2022	Protein lipoylation in mitochondria requires Fe-S cluster assembly factors NFU4 and NFU5.	Iron	45-49	NFU domain protein 5	Arabidopsis thaliana	84-88
34746593-1	2021	A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line.	Iron	82-84	cytochrome c oxidase subunit 8A	Homo sapiens	69-73
16592113-5	1973	The midpoint potentials of the iron-sulfur species fall into two distinctly separate regions: the titration profile of the g = 1.94 signal, the first segment of the g = 2.05 plot, and the rise phase of the g = 1.86 signal had a value of -530 +/- 5 mV; the upper segment of the g = 2.05 plot, the decrease phase of the g = 1.86 signal, and the g = 1.89 profile had a midpoint potential estimated to be [unk] -580 mV.	Iron	31-35	unk zinc finger	Homo sapiens	402-405
34768831-1	2021	The metal cation symporter ZIP8 (SLC39A8) is a transmembrane protein that imports the essential micronutrients iron, manganese, and zinc, as well as heavy toxic metal cadmium (Cd).	Iron	111-115	solute carrier family 39 member 8	Homo sapiens	27-31
5276301-9	1971	Carotid body extracts and efferent blood plasma exhibited erythropoietin activity, which was demonstrated in the polycythemic rat by the (59)Fe incorporation method.	Iron	141-143	erythropoietin	Rattus norvegicus	58-72
5480864-0	1970	The role of ceruloplasmin in iron metabolism.	Iron	29-33	ceruloplasmin	Homo sapiens	12-25
5480864-8	1970	Rat ceruloplasmin, which has little ferroxidase activity, was much less effective than porcine or human ceruloplasmin in inducing increases in plasma iron.	Iron	150-154	ceruloplasmin	Homo sapiens	104-117
5480864-10	1970	Eight patients with Wilson"s disease were evaluated in order to investigate iron metabolism in a disorder characterized by reduced ceruloplasmin levels.	Iron	76-80	ceruloplasmin	Homo sapiens	131-144
34768831-1	2021	The metal cation symporter ZIP8 (SLC39A8) is a transmembrane protein that imports the essential micronutrients iron, manganese, and zinc, as well as heavy toxic metal cadmium (Cd).	Iron	111-115	solute carrier family 39 member 8	Homo sapiens	33-40
5497445-0	1970	Incorporation of radioactive iron into cytochrome b5 and cytochrome P-450 of liver microsomes.	Iron	29-33	cytochrome b5 type A	Homo sapiens	39-52
34733841-0	2021	RNA m6A Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma via Targeting Regulators of Iron Metabolism.	Iron	105-109	alkB homolog 5, RNA demethylase	Homo sapiens	20-26
32523182-1	1970	Photoionization yield curves from onset to 600A, and ionization threshold values have been obtained for the ions Fe ( CO ) 5 +   , Fe ( CO ) 4 +   , Fe ( CO ) 3 +   , Fe ( CO ) 2 +   , Fe ( CO ) +   , Fe+ and CO+ from iron penta-carbonyl, and for Ni ( CO ) 4 +   , Ni ( CO ) 3 +   , Ni ( CO ) 2 +   , Ni ( CO ) +   , Ni+, and CO+ from nickel tetracarbonyl.	Iron	131-133	complement C4A (Rodgers blood group)	Homo sapiens	136-142
34733841-5	2021	Furthermore, mRNAs encoding ubiquitin ligase FBXL5, and mitochondrial iron importers SLC25A28 and SLC25A37, were identified as substrates of ALKBH5.	Iron	70-74	alkB homolog 5, RNA demethylase	Homo sapiens	141-147
32523182-1	1970	Photoionization yield curves from onset to 600A, and ionization threshold values have been obtained for the ions Fe ( CO ) 5 +   , Fe ( CO ) 4 +   , Fe ( CO ) 3 +   , Fe ( CO ) 2 +   , Fe ( CO ) +   , Fe+ and CO+ from iron penta-carbonyl, and for Ni ( CO ) 4 +   , Ni ( CO ) 3 +   , Ni ( CO ) 2 +   , Ni ( CO ) +   , Ni+, and CO+ from nickel tetracarbonyl.	Iron	131-133	complement C4A (Rodgers blood group)	Homo sapiens	136-142
34733841-9	2021	Notably, ALKBH5 overexpression led to a significant reduction in intracellular iron levels as well as cell migratory and invasive abilities, which could be rescued by knocking down FBXL5.	Iron	79-83	alkB homolog 5, RNA demethylase	Homo sapiens	9-15
34547129-9	2021	Our results demonstrate the counteracting effects of overexpression of mitochondrial aconitase (ACO2, a tricarboxylic acid cycle enzyme) or cytosolic aconitase (ACO1, an iron regulatory protein) on IL-1beta secretion and altered iron metabolism.	Iron	170-174	aconitase 1	Homo sapiens	161-165
34547129-9	2021	Our results demonstrate the counteracting effects of overexpression of mitochondrial aconitase (ACO2, a tricarboxylic acid cycle enzyme) or cytosolic aconitase (ACO1, an iron regulatory protein) on IL-1beta secretion and altered iron metabolism.	Iron	229-233	aconitase 1	Homo sapiens	161-165
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	182-184	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	130-137
5789574-0	1969	Relation of ferroxidase (ceruloplasmin) to iron absorption.	Iron	43-47	ceruloplasmin	Homo sapiens	25-38
34548401-10	2021	Moreover, the transcription of both BTS and IMA3 is activated directly by bHLH105 and bHLH115 under Fe-deficient conditions.	Iron	100-102	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	74-81
34548401-11	2021	Our findings provide a conceptual framework for understanding the regulation of Fe homeostasis: IMA peptides protect bHLH105/bHLH115 from degradation by sequestering BTS, thereby activating the Fe deficiency response.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	117-124
34563261-2	2021	Lipocalin 2 (LCN2), an innate immune protein, plays a crucial role in iron transport and inflammation.	Iron	70-74	lipocalin 2	Mus musculus	13-17
5666112-0	1968	Malabsorption of hemoglobin iron in pernicious anemia: correction with intrinsic factor--containing substances.	Iron	28-32	cobalamin binding intrinsic factor	Homo sapiens	71-87
34460227-6	2021	The obtained results show that compounds APH1, APH2, APH3, APH4, and APH5 were only able to chelate iron and copper ions among all metals studied and that APH3, APH4, and APH5 were also able to chelate mercury ion.	Iron	100-104	alphaprotein 1	Mus musculus	41-45
5666112-2	1968	Crude and purified hog intrinsic factor (IF) concentrates doubled the absorption of hemoglobin iron in these patients as did normal (neutralized depepsinized) human gastric juice.	Iron	95-99	cobalamin binding intrinsic factor	Homo sapiens	23-39
5666112-2	1968	Crude and purified hog intrinsic factor (IF) concentrates doubled the absorption of hemoglobin iron in these patients as did normal (neutralized depepsinized) human gastric juice.	Iron	95-99	cobalamin binding intrinsic factor	Homo sapiens	41-43
5666112-6	1968	Preincubation of the hog IF concentrate with antisera to IF significantly reduced the enhancement of hemoglobin iron absorption due to the concentrate.	Iron	112-116	cobalamin binding intrinsic factor	Homo sapiens	25-27
5666112-6	1968	Preincubation of the hog IF concentrate with antisera to IF significantly reduced the enhancement of hemoglobin iron absorption due to the concentrate.	Iron	112-116	cobalamin binding intrinsic factor	Homo sapiens	57-59
34518441-2	2021	Emerging evidence indicates that transferrin receptor 1 (TfR1) plays vital roles in regulating cellular iron import.	Iron	104-108	transferrin receptor	Homo sapiens	33-55
13939705-0	1962	Formation in vitro of myoglobin from iron, protoporphyrin, apomyoglobin and iron-chelating enzyme.	Iron	37-41	myoglobin	Homo sapiens	22-31
34518441-2	2021	Emerging evidence indicates that transferrin receptor 1 (TfR1) plays vital roles in regulating cellular iron import.	Iron	104-108	transferrin receptor	Homo sapiens	57-61
13939705-0	1962	Formation in vitro of myoglobin from iron, protoporphyrin, apomyoglobin and iron-chelating enzyme.	Iron	76-80	myoglobin	Homo sapiens	22-31
34564516-2	2021	In this work, tannic acid (TA) and polyethyleneimine (PEI) were grafted on the PES/Fe ultrafiltration membrane via the coordination assembly and Michael addition strategy to fabricated a loose nanofiltration membrane (LNM).	Iron	83-85	pescadillo ribosomal biogenesis factor 1	Homo sapiens	79-82
13893908-0	1961	The effect of iron deficiency on myoglobin iron.	Iron	14-18	myoglobin	Homo sapiens	33-42
34488769-10	2021	In particular, the mRNA expression of key iron- sulphur proteins POLD1 and PRIM2 was significantly overexpressed and correlated with poor prognosis in LIHC patients.	Iron	42-46	DNA polymerase delta 1, catalytic subunit	Homo sapiens	65-70
34346124-9	2021	In addition, depression of YAP could impair the effect of curcumol on iron overload and cellular senescence.	Iron	70-74	Yes1 associated transcriptional regulator	Homo sapiens	27-30
13614978-0	1958	[Electron-microscopic aspect of apoferritin more or less saturated with iron; comparison of images observed in the cells with those of chemically prepared substances].	Iron	72-76	ferritin heavy chain 1	Homo sapiens	32-43
34573286-2	2021	Iron homeostasis disorders develop as a result of HFE gene mutations, which are associated with hepcidin arthropathy or osteoporosis and may cause permanent disability in HH patients despite a properly conducted treatment with phlebotomies.	Iron	0-4	homeostatic iron regulator	Homo sapiens	50-53
13499392-0	1957	The incorporation of iron by apoferritin.	Iron	21-25	ferritin heavy chain 1	Homo sapiens	29-40
34272312-6	2021	Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake.	Iron	31-35	transferrin receptor	Mus musculus	45-67
14367535-0	1955	Effect of iron on the biosynthesis of hepatic apoferritin.	Iron	10-14	ferritin heavy chain 1	Homo sapiens	46-57
34272312-6	2021	Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake.	Iron	31-35	transferrin receptor	Mus musculus	69-73
34272312-6	2021	Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake.	Iron	105-109	transferrin receptor	Mus musculus	45-67
34272312-6	2021	Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake.	Iron	105-109	transferrin receptor	Mus musculus	69-73
14935593-2	1951	Nature of muscle iron not contained in the blood; use of radioactive iron in the study of its relation to myosin].	Iron	69-73	myosin heavy chain 14	Homo sapiens	106-112
34272312-10	2021	We show that Schwann cells (SCs) are a likely source as they express the molecular machinery to import iron (transferrin receptor 1), and to export iron (ferroportin and ceruloplasmin (Cp)) to the axonal compartment at the nodes of Ranvier (NR) and Schmidt-Lanterman incisures (SLIs).	Iron	103-107	transferrin receptor	Mus musculus	109-131
34242792-5	2021	Additionally, IDO1 deficiency prevented against APAP-induced liver injury through suppressing the activation of macrophages, thereby reduced their iron uptake and export, eventually reduced iron accumulation in hepatocytes through transferrin and transferrin receptor axis.	Iron	190-194	transferrin receptor	Homo sapiens	247-267
33839281-10	2021	Expression analysis indicated that genes involved in fatty-acid binding and mTOR pathways were regulated by iron depletion.	Iron	108-112	mechanistic target of rapamycin kinase	Mus musculus	76-80
34434202-6	2021	AtMTM1 and AtMTM2 are involved in Mn and Fe homeostasis, root length, and flowering time.	Iron	41-43	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	0-6
33372284-1	2021	Erythroferrone (ERFE) is the main erythroid regulator of hepcidin, the homeostatic hormone controlling plasma iron levels and total body iron.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	57-65
33372284-1	2021	Erythroferrone (ERFE) is the main erythroid regulator of hepcidin, the homeostatic hormone controlling plasma iron levels and total body iron.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	57-65
33372284-3	2021	Increased ERFE then suppresses hepcidin synthesis, thereby mobilizing cellular iron stores for use in heme and hemoglobin synthesis.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	31-39
34441564-8	2021	RNA-seq and signaling pathway analyses showed that iron overload caused ferroptosis in the liver of mice with a decrease in GPX4 expression and an increase in Ptgs2 expression, resulting in a high level of lipid peroxidation.	Iron	51-55	prostaglandin-endoperoxide synthase 2	Mus musculus	159-164
33316086-1	2021	The discovery of hepcidin has provided a solid foundation for understanding the mechanisms of systemic iron homeostasis and the aetiologies of iron disorders.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	17-25
33316086-2	2021	Hepcidin assures the balance of circulating and stored iron levels for multiple physiological processes including oxygen transport and erythropoiesis, while limiting the toxicity of excess iron.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
33316086-2	2021	Hepcidin assures the balance of circulating and stored iron levels for multiple physiological processes including oxygen transport and erythropoiesis, while limiting the toxicity of excess iron.	Iron	189-193	hepcidin antimicrobial peptide	Homo sapiens	0-8
33316086-3	2021	The liver is the major site where regulatory signals from iron, erythropoietic drive and inflammation are integrated to control hepcidin production.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	128-136
34126150-1	2021	The aim of this study was to synthesize iron magnetic nanoparticles functionalized with histidine and nickel (Fe3O4-His-Ni) to be used as support materials for oriented immobilization of His-tagged recombinant enzymes of high molecular weight, using beta-galactosidase as a model.	Iron	40-44	galactosidase beta 1	Homo sapiens	250-268
33316086-4	2021	Pathologically, hepcidin dysregulation by genetic inactivation, ineffective erythropoiesis, or inflammation leads to diseases of iron deficiency or overload such as iron-refractory iron-deficiency anaemia, anaemia of inflammation, iron-loading anaemias and hereditary haemochromatosis.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	16-24
34126150-9	2021	The iron nanoparticles functionalized with histidine and nickel were efficient in the oriented immobilization of the recombinant beta-galactosidase, showing its potential application in other high-molecular-weight enzymes.	Iron	4-8	galactosidase beta 1	Homo sapiens	129-147
34059542-6	2021	To our knowledge, this case is the first demonstration that combined heart-liver transplantation is a feasible option for patients with heart and liver failure secondary to HJV-associated haemochromatosis and indeed offers a long-standing corrective solution to treat this condition and restore physiologically normal iron metabolism.	Iron	318-322	hemojuvelin BMP co-receptor	Homo sapiens	173-176
34927877-3	2021	The ionization of elements and their recombination process during arc discharge allows the simultaneous incorporation of single metal atoms (Mn, Fe, Co, Ni, and Pt) into the crystalline carbon lattice during the formation of carbon nanohorns (CNHs) and N-doped arc graphene.	Iron	145-147	activity regulated cytoskeleton associated protein	Homo sapiens	66-69
34034544-0	2022	Lif Deficiency Leads to Iron Transportation Dysfunction in Ameloblasts.	Iron	24-28	leukemia inhibitory factor	Mus musculus	0-3
34361012-0	2021	Rare Gain-of-Function KCND3 Variant Associated with Cerebellar Ataxia, Parkinsonism, Cognitive Dysfunction, and Brain Iron Accumulation.	Iron	118-122	potassium voltage-gated channel subfamily D member 3	Homo sapiens	22-27
34034544-7	2022	In Lif-/- mice, whose general iron status was comparable to that of the control mice, the iron content of the incisors was significantly reduced, as confirmed by energy-dispersive X-ray spectroscopy (EDS) and Prussian blue staining.	Iron	30-34	leukemia inhibitory factor	Mus musculus	3-6
34034544-7	2022	In Lif-/- mice, whose general iron status was comparable to that of the control mice, the iron content of the incisors was significantly reduced, as confirmed by energy-dispersive X-ray spectroscopy (EDS) and Prussian blue staining.	Iron	90-94	leukemia inhibitory factor	Mus musculus	3-6
34034544-9	2022	Likewise, decreased expression of Tfrc and Slc40a1, both of which are crucial proteins for iron transportation, was observed in Lif-/- mice and Lif-knockdown ameloblast lineage cell lines, according to quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot.	Iron	91-95	leukemia inhibitory factor	Mus musculus	128-131
34034544-9	2022	Likewise, decreased expression of Tfrc and Slc40a1, both of which are crucial proteins for iron transportation, was observed in Lif-/- mice and Lif-knockdown ameloblast lineage cell lines, according to quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot.	Iron	91-95	leukemia inhibitory factor	Mus musculus	144-147
34034544-11	2022	These results suggest that Lif deficiency inhibits iron transportation in the maturation-stage ameloblasts, and Lif modulates expression of Tfrc and Slc40a1 through the Stat3 signaling pathway during enamel development.	Iron	51-55	leukemia inhibitory factor	Mus musculus	27-30
34361012-4	2021	Here, we aim to ascertain the potential pathogenic role of KCND3 variant in iron accumulation-related cerebellar ataxia.	Iron	76-80	potassium voltage-gated channel subfamily D member 3	Homo sapiens	59-64
34361012-9	2021	These observations indicate that, in direct contrast with the loss-of-function KCND3 mutations previously reported in cerebellar ataxia patients, we identified a rare gain-of-function KCND3 variant that may expand the clinical and molecular spectra of neurodegenerative cerebellar disorders associated with brain iron accumulation.	Iron	313-317	potassium voltage-gated channel subfamily D member 3	Homo sapiens	184-189
34044072-9	2021	Two weeks after continuous administration, iron-overloaded mice treated with high and low doses of RES significantly improved liver injury (GOT and GPT) and decreased LDH activity and MDA content and increased SOD and GSH activities (P < 0.01).	Iron	43-47	glutamic pyruvic transaminase, soluble	Mus musculus	148-151
34361737-4	2021	Indeed, the precipitation of Fe(III) at pH > 4 interferes with the recycling of Fe species and inhibits oxidation in homogeneous Fenton; in contrast, suspended ZVI as iron source is less sensitive to the increase of pH.	Iron	80-82	phenylalanine hydroxylase	Homo sapiens	40-42
34023349-0	2021	CERULOPLASMIN VARIANTS MIGHT HAVE DIFFERENT EFFECTS IN DIFFERENT IRON OVERLOAD DISORDERS.	Iron	65-69	ceruloplasmin	Homo sapiens	0-13
34361737-4	2021	Indeed, the precipitation of Fe(III) at pH > 4 interferes with the recycling of Fe species and inhibits oxidation in homogeneous Fenton; in contrast, suspended ZVI as iron source is less sensitive to the increase of pH.	Iron	80-82	phenylalanine hydroxylase	Homo sapiens	216-218
34361737-4	2021	Indeed, the precipitation of Fe(III) at pH > 4 interferes with the recycling of Fe species and inhibits oxidation in homogeneous Fenton; in contrast, suspended ZVI as iron source is less sensitive to the increase of pH.	Iron	167-171	phenylalanine hydroxylase	Homo sapiens	216-218
34300874-0	2021	Tailings after Iron Extraction in Bayer Red Mud by Biomass Reduction: Pozzolanic Activity and Hydration Characteristics.	Iron	15-19	adaptor related protein complex 5 subunit mu 1	Homo sapiens	44-47
33900076-4	2021	The estimated hydricity (50 kcal/mol) based on observed H/D exchange with BD3 requires Fe-O bond formation in the product to offset an endergonic CO2 insertion.	Iron	87-89	defensin beta 103B	Homo sapiens	74-77
34367815-0	2021	Iatrogenic Iron Overload Causing Porphyria Cutanea Tarda in a Patient With a Rare Nonsense Heterozygous UROD Gene Mutation.	Iron	11-15	uroporphyrinogen decarboxylase	Homo sapiens	104-108
34015331-3	2021	Production of aldosterone by cytochrome P450 11B2 (CYP11B2, aldosterone synthase) requires two reduction events with the electrons delivered by the iron/sulfur protein adrenodoxin.	Iron	148-152	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	29-49
34015331-3	2021	Production of aldosterone by cytochrome P450 11B2 (CYP11B2, aldosterone synthase) requires two reduction events with the electrons delivered by the iron/sulfur protein adrenodoxin.	Iron	148-152	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	51-58
34015331-3	2021	Production of aldosterone by cytochrome P450 11B2 (CYP11B2, aldosterone synthase) requires two reduction events with the electrons delivered by the iron/sulfur protein adrenodoxin.	Iron	148-152	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	60-80
34367815-11	2021	UROD is inactivated in an iron-dependent process, explaining the mechanistic link between hemochromatosis and PCT.	Iron	26-30	uroporphyrinogen decarboxylase	Homo sapiens	0-4
34055782-0	2021	JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration.	Iron	25-29	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
34359830-2	2021	LCN2 inhibits bacterial growth by iron sequestration and regulates the innate immune system.	Iron	34-38	lipocalin 2	Mus musculus	0-4
34389107-7	2021	In the placenta, the rate of iron uptake by transferrin receptor TfR1 at the apical/maternal side and of iron release by ferroportin FPN at the basal/fetal side is controlled by IRP1.	Iron	29-33	transferrin receptor	Homo sapiens	44-64
33979838-1	2021	BACKGROUND: Overweight or obesity among pregnant women may compromise maternal and neonatal iron status by upregulating hepcidin.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	120-128
33979838-2	2021	OBJECTIVES: This study determined the association of 1) maternal and neonatal iron status with maternal and neonatal hepcidin concentrations, and 2) maternal prepregnancy weight status with maternal and neonatal hepcidin concentrations.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	117-125
33979838-7	2021	RESULTS: Maternal iron status was positively correlated with maternal hepcidin at mid-pregnancy (SF: r = 0.63, P < 0.001; sTfR: r = -0.37, P < 0.001).	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	70-78
34389107-7	2021	In the placenta, the rate of iron uptake by transferrin receptor TfR1 at the apical/maternal side and of iron release by ferroportin FPN at the basal/fetal side is controlled by IRP1.	Iron	29-33	transferrin receptor	Homo sapiens	65-69
33979838-8	2021	Neonatal iron status was also positively correlated with cord hepcidin (SF: r = 0.61, P < 0.001; sTfR: r = -0.39, P < 0.001).	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	62-70
33979838-10	2021	Using path analysis, we observed a significant indirect effect of maternal prepregnancy overweight or obese status on cord hepcidin, mediated by neonatal iron status.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	123-131
34389107-7	2021	In the placenta, the rate of iron uptake by transferrin receptor TfR1 at the apical/maternal side and of iron release by ferroportin FPN at the basal/fetal side is controlled by IRP1.	Iron	29-33	aconitase 1	Homo sapiens	178-182
33979838-11	2021	CONCLUSIONS: In both pregnant women and neonates, hepcidin was responsive to iron status.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	50-58
33979838-12	2021	Maternal prepregnancy overweight status, with or without including obese women, was associated with lower cord blood hepcidin, likely driven by lower iron status among the neonates of these mothers.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	117-125
34389107-7	2021	In the placenta, the rate of iron uptake by transferrin receptor TfR1 at the apical/maternal side and of iron release by ferroportin FPN at the basal/fetal side is controlled by IRP1.	Iron	105-109	aconitase 1	Homo sapiens	178-182
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	91-95	aconitase 1	Homo sapiens	23-55
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	91-95	aconitase 1	Homo sapiens	57-61
34108960-9	2021	Specifically, iron inhibits the differentiation of naive CD4+ T cells to protective IFNgamma producing Th1 lymphocytes via stimulation of TIM-3 expression.	Iron	14-18	hepatitis A virus cellular receptor 2	Mus musculus	138-143
34108960-10	2021	Finally, TIM-3 may serve as a novel drug target for the treatment of chronic infections with intracellular pathogens, specifically in iron loading diseases.	Iron	134-138	hepatitis A virus cellular receptor 2	Mus musculus	9-14
34063414-4	2021	High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import.	Iron	108-112	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	94-98
34063414-7	2021	It was previously established that Dmt1 knock down prevented iron-loading in weanling Hamp (encoding hepcidin) KO mice (modeling type 2B HH).	Iron	61-65	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	35-39
34063414-11	2021	For example, Dmt1 siRNA treatment suppressed duodenal Dmt1 mRNA expression (by ~50%) and reduced serum and liver non-heme iron levels (by ~60% and >85%, respectively).	Iron	122-126	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	13-17
34063414-14	2021	In conclusion, the combinatorial approach of FA-GDLV and Dmt1 siRNA treatment, with dietary iron restriction, mitigated pre-existing iron overload in a murine model of HH.	Iron	133-137	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	57-61
34068996-8	2021	Based on Tet methylcytosine dioxygenase 2 (TET2), representing one of the most frequently mutated genes in MDS, leading to disturbances in both iron homeostasis and hematopoiesis, we highlight that different genetic alteration may have different implications and that a comprehensive workup is needed for a complete understanding and development of future therapies.	Iron	144-148	tet methylcytosine dioxygenase 2	Homo sapiens	9-41
34068996-8	2021	Based on Tet methylcytosine dioxygenase 2 (TET2), representing one of the most frequently mutated genes in MDS, leading to disturbances in both iron homeostasis and hematopoiesis, we highlight that different genetic alteration may have different implications and that a comprehensive workup is needed for a complete understanding and development of future therapies.	Iron	144-148	tet methylcytosine dioxygenase 2	Homo sapiens	43-47
35500346-4	2022	(2022) published a high academic paper to reveal the adsorption properties and mechanism of dyes onto the chitosan composite of the iron metal-organic framework (CS/MOF-235).	Iron	132-142	citrate synthase	Homo sapiens	162-164
35597374-7	2022	The nonswelling P(AA-MEA)-CS-Fe hydrogel shows huge potential in underwater sensing.	Iron	29-31	citrate synthase	Homo sapiens	26-28
35441752-0	2022	Erratum to: Limits of Fat Quantification in the Presence of Iron Overload (J Magn Reson Imaging.	Iron	60-64	FAT atypical cadherin 1	Homo sapiens	22-25
35285505-9	2022	Like overexpression of NAC5, overexpression of NFYA8 increases primary root length, lateral root number, ferric reductase activity, and mRNA abundance of IRT1 and FRO2 under Fe-deficient conditions.	Iron	174-176	ferric reduction oxidase 2	Arabidopsis thaliana	163-167
35306710-0	2022	Autophagy triggered by iron mediated ER stress is an important stress response to the early phase of Pi starvation in plants.	Iron	23-27	epiregulin	Homo sapiens	37-39
35306710-10	2022	Furthermore, iron limitation and inhibition of lipid-ROS accumulation suppressed the ER-phagy.	Iron	13-17	epiregulin	Homo sapiens	85-87
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	103-107	hephaestin	Mus musculus	70-80
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	103-107	hephaestin	Mus musculus	82-86
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	128-132	hephaestin	Mus musculus	70-80
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	128-132	hephaestin	Mus musculus	82-86
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	150-154	hephaestin	Mus musculus	70-80
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	150-154	hephaestin	Mus musculus	82-86
35271829-9	2022	These findings indicate that Heph has a local role in regulating neural retina iron homeostasis, but also suggest that preserved Heph function in either the RPE or systemically mitigates the degeneration phenotype observed in the systemic Cp-/-, Heph-/- mice.	Iron	79-83	hephaestin	Mus musculus	29-33
35271829-9	2022	These findings indicate that Heph has a local role in regulating neural retina iron homeostasis, but also suggest that preserved Heph function in either the RPE or systemically mitigates the degeneration phenotype observed in the systemic Cp-/-, Heph-/- mice.	Iron	79-83	hephaestin	Mus musculus	129-133
35106609-0	2022	Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway.	Iron	61-65	glycogen synthase kinase 3 alpha	Mus musculus	94-102
35106609-12	2022	CONCLUSION: These findings indicated hops and xanthohumol could ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway, which brought up a novel sight for senile osteoporosis therapy.	Iron	96-100	glycogen synthase kinase 3 alpha	Mus musculus	129-137
35101526-0	2022	COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.	Iron	96-98	COMM domain containing 10	Homo sapiens	0-7
35477568-2	2022	Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in hepatic steatosis and iron regulation.	Iron	133-137	bone morphogenetic protein 4	Homo sapiens	0-28
35477568-2	2022	Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in hepatic steatosis and iron regulation.	Iron	133-137	bone morphogenetic protein 4	Homo sapiens	30-34
35474632-5	2022	We demonstrate that co-presence of bacterial frataxin and iron is necessary to observe an inhibitory effect of the enzymatic activity of bacterial frataxin.	Iron	58-62	frataxin	Homo sapiens	147-155
35472080-4	2022	Mice deficient for autophagy in macrophages (LysM-Atg5-/-) mimicked a primary iron overload phenotype, resulting in high ferroportin expression in both macrophages and enterocytes that correlated with marked parenchymal iron overload.	Iron	220-224	autophagy related 5	Mus musculus	50-54
35472080-5	2022	Furthermore, LysM-Atg5-/- mice exhibited increased hematopoietic activity with no sign of anemia but correlating with rather high plasma iron level.	Iron	137-141	autophagy related 5	Mus musculus	18-22
35472080-6	2022	Compared to wild-type cells, bone marrow-derived macrophages from LysM-Atg5-/- mice had significantly increased ferroportin expression and a decreased iron content, confirming high iron export.	Iron	151-155	autophagy related 5	Mus musculus	71-75
35473441-3	2022	Here, we report that in retinal pigmented epithelial (RPE) cells, LCN2 regulates macroautophagy/autophagy, in addition to maintaining iron homeostasis.	Iron	134-138	lipocalin 2	Mus musculus	66-70
35470541-2	2022	In this work, Fe-doped MOF-derived N-rich porous carbon nanoframe was successfully fabricated by pyrolysis of Fe-doped ZIF-8 in an Ar atmosphere at a temperature of 900  C, and used for H2 S cataluminescence sensing.	Iron	110-112	lysine acetyltransferase 8	Homo sapiens	23-26
35591429-6	2022	SEM images confirmed the dissolution of the aluminium matrix near the separated iron-rich phases of the Alx form (Fe, Mn) by the action of galvanic cells.	Iron	80-84	hematopoietic SH2 domain containing	Homo sapiens	104-107
33949744-0	2021	Serum Ceruloplasmin Depletion is Associated With Magnetic Resonance Evidence of Widespread Accumulation of Brain Iron in Parkinson"s Disease.	Iron	113-117	ceruloplasmin	Homo sapiens	6-19
33949744-2	2021	Ceruloplasmin plays an important role in keeping the iron homoeostasis.	Iron	53-57	ceruloplasmin	Homo sapiens	0-13
33949744-3	2021	PURPOSE: To explore the association between serum ceruloplasmin depletion and subcortical iron distribution in PD.	Iron	90-94	ceruloplasmin	Homo sapiens	50-63
33949744-11	2021	Partial correlation analysis was used to detect the association between regional iron distribution and serum ceruloplasmin concentration (P < 0.05).	Iron	81-85	ceruloplasmin	Homo sapiens	109-122
33949744-13	2021	Between PD-NC and PD-LC, the iron accumulation in putamen remained significantly different, which had a negative correlation with serum ceruloplasmin in whole PD patients (r = -0.338, P = 0.008).	Iron	29-33	ceruloplasmin	Homo sapiens	136-149
33949744-15	2021	Differentially, when PD patients appear with reduced serum ceruloplasmin, more widespread iron accumulation would be expected with additionally involving putamen and red nucleus.	Iron	90-94	ceruloplasmin	Homo sapiens	59-72
33949744-16	2021	All these findings provide insightful evidence for the abnormal iron metabolism behind the ceruloplasmin depletion in PD.	Iron	64-68	ceruloplasmin	Homo sapiens	91-104
33843193-1	2021	The application of nanosized zerovalent iron (nZVI) for reductive immobilization of selenite (Se(IV)) or selenate (Se(VI)) alone has been extensively investigated.	Iron	40-44	squalene epoxidase	Homo sapiens	115-121
35591429-6	2022	SEM images confirmed the dissolution of the aluminium matrix near the separated iron-rich phases of the Alx form (Fe, Mn) by the action of galvanic cells.	Iron	114-116	hematopoietic SH2 domain containing	Homo sapiens	104-107
33843193-9	2021	The formation of lepidocrocite contributed to the enrichment of Se(VI) on the nZVI surface, and magnetite promoted electron transfer from Fe(0) to Se(VI).	Iron	138-143	squalene epoxidase	Homo sapiens	147-153
35459748-9	2022	These data suggest that Fe is an important biological co-factor for Dbr1 enzymes.	Iron	24-26	debranching RNA lariats 1	Homo sapiens	68-72
34012440-12	2021	This was accompanied by reduced expression of DMT-1, an iron transport protein.	Iron	56-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	46-51
35624674-8	2022	We further elucidated that PPARdelta modulated cellular iron homeostasis by regulating expression of divalent metal transporter 1, ferroportin 1, and ferritin, but not transferrin receptor 1, through iron regulatory protein 1 in 6-OHDA-treated cells.	Iron	56-60	aconitase 1	Homo sapiens	200-225
33952394-10	2021	CONCLUSION: Data from CBC and RET-He can identify patients with IDA, determine need for and responsiveness to intravenous iron, and reduce time for therapeutic decisions.	Iron	122-126	ret proto-oncogene	Homo sapiens	30-33
35436090-3	2022	The dualism of N-dopants and binary metals lower the d-band centers of both Fe and Co in the Fe,Co,N-C catalyst, improving the overpotential of the overall electrocatalytic processes (DeltaEORR-OER = 0.74 +- 0.02 V vs RHE).	Iron	76-78	factor interacting with PAPOLA and CPSF1	Homo sapiens	218-221
33978363-0	2021	The Hepcidin and 25-OH-Vitamin D Levels in Obese Children as a Potential Mediator of the Iron Status.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	4-12
35436090-3	2022	The dualism of N-dopants and binary metals lower the d-band centers of both Fe and Co in the Fe,Co,N-C catalyst, improving the overpotential of the overall electrocatalytic processes (DeltaEORR-OER = 0.74 +- 0.02 V vs RHE).	Iron	93-95	factor interacting with PAPOLA and CPSF1	Homo sapiens	218-221
35421237-9	2022	Concomitantly, ME1 absence drives the accumulation of ROS and labile iron.	Iron	69-73	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	15-18
33722625-7	2021	Transcriptome analysis indicates that clusters of genes are up-or down-regulated in aged LECs, impacting cellular redox and iron homeostases, such as downregulation of both cystine/glutamate antiporter subunits SLC7A11 and SLC3A2 and iron exporter ferroportin (SLC40A1).	Iron	124-128	solute carrier family 7 member 11	Homo sapiens	211-218
33722625-7	2021	Transcriptome analysis indicates that clusters of genes are up-or down-regulated in aged LECs, impacting cellular redox and iron homeostases, such as downregulation of both cystine/glutamate antiporter subunits SLC7A11 and SLC3A2 and iron exporter ferroportin (SLC40A1).	Iron	124-128	solute carrier family 3 member 2	Homo sapiens	223-229
33722625-7	2021	Transcriptome analysis indicates that clusters of genes are up-or down-regulated in aged LECs, impacting cellular redox and iron homeostases, such as downregulation of both cystine/glutamate antiporter subunits SLC7A11 and SLC3A2 and iron exporter ferroportin (SLC40A1).	Iron	124-128	solute carrier family 40 member 1	Homo sapiens	261-268
35421237-10	2022	ROS and iron accumulation enhances the susceptibility of ME1 null cells to ferroptosis induction with inhibitors of xCT (erastin and ACXT-3102).	Iron	8-12	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	57-60
35514788-0	2022	Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: Potential implications for SARS-CoV-2 infection.	Iron	83-87	angiotensin converting enzyme 2	Homo sapiens	52-56
33025407-2	2021	Our understanding of the molecular control of iron metabolism has increased dramatically over the past 20 years due to the discovery of hepcidin, which regulates the uptake of dietary iron and its mobilization from macrophages and hepatic stores.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	136-144
33025407-2	2021	Our understanding of the molecular control of iron metabolism has increased dramatically over the past 20 years due to the discovery of hepcidin, which regulates the uptake of dietary iron and its mobilization from macrophages and hepatic stores.	Iron	184-188	hepcidin antimicrobial peptide	Homo sapiens	136-144
33025407-10	2021	Furthermore, the hepcidin-lowering effect of ERFE in ESRD patients treated with erythropoiesis-stimulating agents (ESAs) may be blunted by underlying inflammation and concomitant iron treatment.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	17-25
35152755-5	2022	As a model system for a non-transparent food colloid such as mayonnaise, we designed an oil-in-water emulsion containing the ferric ion binding protein phosvitin commonly present in egg yolk.	Iron	125-135	casein kinase 2 beta	Homo sapiens	152-161
33610598-7	2021	The results indicated that heparin-iron has significantly reduced anticoagulant activity in vitro and in vivo, strongly decreases hepcidin mRNA and IL-6 induced high level of secreted hepcidin in HepG2 cell.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	130-138
33610598-7	2021	The results indicated that heparin-iron has significantly reduced anticoagulant activity in vitro and in vivo, strongly decreases hepcidin mRNA and IL-6 induced high level of secreted hepcidin in HepG2 cell.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	184-192
35118832-9	2022	RESULTS: In vitro, iron exposure caused dose-dependent increases of iron storage protein ferritin (P < 0.01) and dose-dependent decreases of mRNA TfR1 levels (P < 0.001), which support cellular adaptations to iron excess.	Iron	19-23	transferrin receptor	Mus musculus	146-150
33863580-8	2021	In endometriosis, total iron showed a positive correlation with HO-1 (r, 0.518, p = 0.001), but there were no antioxidants that correlated with iron in non-endometriosis.	Iron	24-28	heme oxygenase 1	Homo sapiens	64-68
33863580-10	2021	CONCLUSIONS: HO-1 may regulate the delicate balance of iron-induced oxidative stress in endometriotic cyst fluid.	Iron	55-59	heme oxygenase 1	Homo sapiens	13-17
33844625-3	2021	Finally, we propose how the application for cancer drug repurposing delivery within apoferritin could expand cancer treatment in the future.Expert opinion: Being a ubiquitous iron storage protein that exists in many living organisms, apoferritin is promising as a cancer tumor-targeting nanocarrier.	Iron	175-179	ferritin heavy chain 1	Homo sapiens	234-245
33898455-1	2021	3-hydroxybutyrate dehydrogenase-2 (Bdh2), a short-chain dehydrogenase, catalyzes a rate-limiting step in the biogenesis of the mammalian siderophore, playing a key role in iron homeostasis, energy metabolism and apoptosis.	Iron	172-176	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	35-39
33834418-0	2021	HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species.	Iron	82-86	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	6-11
33834418-0	2021	HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species.	Iron	119-123	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	6-11
33834418-4	2021	Based on those findings, we tested the hypothesis that HIV-1 gp120-induced endolysosome de-acidification and subsequent iron efflux from endolysosomes is responsible for increased levels of ROS.	Iron	120-124	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	61-66
33834418-5	2021	In U87MG glioblastoma cells, HIV-1 gp120 de-acidified endolysosomes, reduced endolysosome iron levels, increased levels of cytosolic and mitochondrial iron, and increased levels of cytosolic and mitochondrial ROS.	Iron	90-94	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	35-40
33834418-5	2021	In U87MG glioblastoma cells, HIV-1 gp120 de-acidified endolysosomes, reduced endolysosome iron levels, increased levels of cytosolic and mitochondrial iron, and increased levels of cytosolic and mitochondrial ROS.	Iron	151-155	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	35-40
33834418-6	2021	These effects were all attenuated significantly by the endolysosome-specific iron chelator deferoxamine, by inhibitors of endolysosome-resident two-pore channels and divalent metal transporter-1 (DMT-1), and by inhibitors of mitochondria-resident DMT-1 and mitochondrial permeability transition pores.	Iron	77-81	solute carrier family 11 member 2	Homo sapiens	196-201
33834418-6	2021	These effects were all attenuated significantly by the endolysosome-specific iron chelator deferoxamine, by inhibitors of endolysosome-resident two-pore channels and divalent metal transporter-1 (DMT-1), and by inhibitors of mitochondria-resident DMT-1 and mitochondrial permeability transition pores.	Iron	77-81	solute carrier family 11 member 2	Homo sapiens	247-252
33834418-7	2021	These results suggest that oxidative stress commonly observed with HIV-1 gp120 is downstream of its ability to de-acidify endolysosomes, to increase the release of iron from endolysosomes, and to increase the uptake of iron into mitochondria.	Iron	164-168	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	73-78
33834418-7	2021	These results suggest that oxidative stress commonly observed with HIV-1 gp120 is downstream of its ability to de-acidify endolysosomes, to increase the release of iron from endolysosomes, and to increase the uptake of iron into mitochondria.	Iron	219-223	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	73-78
33953422-1	2021	Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils.	Iron	23-27	lactotransferrin	Mus musculus	0-11
33953422-1	2021	Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils.	Iron	23-27	lactotransferrin	Mus musculus	13-15
33953422-3	2021	Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms.	Iron	30-34	lactotransferrin	Mus musculus	0-2
33953422-3	2021	Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms.	Iron	85-89	lactotransferrin	Mus musculus	0-2
33953422-3	2021	Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms.	Iron	85-89	lactotransferrin	Mus musculus	0-2
33515046-11	2021	However, hepcidin concentration was lower in infants with ID and was higher when inflammation was present, supporting that infants have a functional hepcidin response to changes in iron stores.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	149-157
33987429-3	2021	This disease is characterized by reduced expression of the iron-regulatory hormone hepcidin, leading to increased dietary iron absorption and iron deposition in multiple tissues including the liver, pancreas, joints, heart and pituitary.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	83-91
33987429-3	2021	This disease is characterized by reduced expression of the iron-regulatory hormone hepcidin, leading to increased dietary iron absorption and iron deposition in multiple tissues including the liver, pancreas, joints, heart and pituitary.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	83-91
33987429-3	2021	This disease is characterized by reduced expression of the iron-regulatory hormone hepcidin, leading to increased dietary iron absorption and iron deposition in multiple tissues including the liver, pancreas, joints, heart and pituitary.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	83-91
33537805-3	2021	HO-1 is the rate-limiting enzyme of heme catabolism, which splits heme into biliverdin, carbon monoxide (CO) and iron.	Iron	113-117	heme oxygenase 1	Homo sapiens	0-4
32610342-0	2021	Hepcidin is a relevant iron status indicator in infancy: results from a randomized trial of early vs. delayed cord clamping.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
32610342-1	2021	BACKGROUND: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	47-55
32610342-10	2021	CONCLUSIONS: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	13-21
32610342-12	2021	IMPACT: Serum hepcidin is a relevant indicator of iron status in early infancy.Normal reference in healthy infants is suggested in this study.Serum hepcidin may be useful in clinical practice to detect iron deficiency.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	14-22
32610342-12	2021	IMPACT: Serum hepcidin is a relevant indicator of iron status in early infancy.Normal reference in healthy infants is suggested in this study.Serum hepcidin may be useful in clinical practice to detect iron deficiency.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	148-156
33676096-9	2021	Owing to the upregulated expression of acyl-CoA synthetase long-chain family member 4 detected in the yolk sac, we assumed that the ferroptosis of the yolk sac was perhaps caused by the accumulation of reactive oxygen species, which was induced by the large amount of polyunsaturated fatty acids and influx of iron in the yolk.	Iron	310-314	acyl-CoA synthetase long chain family member 4	Gallus gallus	39-85
33493440-1	2021	Ferroptosis is a type of iron-dependent, non-apoptotic cell death, which is typically induced by cysteine starvation or by the inhibition of glutathione peroxidase 4 (GPX4) activity with the accompanying elevation in lipid peroxidation product levels.	Iron	25-29	glutathione peroxidase 4	Mus musculus	141-165
33493440-1	2021	Ferroptosis is a type of iron-dependent, non-apoptotic cell death, which is typically induced by cysteine starvation or by the inhibition of glutathione peroxidase 4 (GPX4) activity with the accompanying elevation in lipid peroxidation product levels.	Iron	25-29	glutathione peroxidase 4	Mus musculus	167-171
33842333-3	2021	In parallel, immune activation inevitably induces the iron-regulatory hormone hepcidin to direct iron fluxes away from erythroid progenitors and into compartments of the mononuclear phagocyte system.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	78-86
33842333-3	2021	In parallel, immune activation inevitably induces the iron-regulatory hormone hepcidin to direct iron fluxes away from erythroid progenitors and into compartments of the mononuclear phagocyte system.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	78-86
33159788-5	2021	CAT2 loss-of-function plants displayed severe susceptibility to Fe deficiency and greatly increased H2O2 levels in roots.	Iron	64-66	cationic amino acid transporter 2	Arabidopsis thaliana	0-4
33159788-6	2021	Analysis of the Fe homeostasis transcriptional cascade revealed that H2O2 influences the gene expression of downstream regulators FIT, BHLHs of group Ib and POPEYE (PYE), however H2O2 did not affect their upstream regulators, such as BHLH104 and ILR3.	Iron	16-18	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	157-163
33159788-6	2021	Analysis of the Fe homeostasis transcriptional cascade revealed that H2O2 influences the gene expression of downstream regulators FIT, BHLHs of group Ib and POPEYE (PYE), however H2O2 did not affect their upstream regulators, such as BHLH104 and ILR3.	Iron	16-18	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	165-168
33159788-6	2021	Analysis of the Fe homeostasis transcriptional cascade revealed that H2O2 influences the gene expression of downstream regulators FIT, BHLHs of group Ib and POPEYE (PYE), however H2O2 did not affect their upstream regulators, such as BHLH104 and ILR3.	Iron	16-18	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	234-241
33796002-7	2021	Iron accumulation may affect long-term cognitive dysfunction from three pathways: local injury, iron deposition induces tau phosphorylation, the formation of neurofibrillary tangles; neural cells death; and neural network damage, iron deposition leads to axonal injury by utilizing the iron sensibility of oligodendrocytes.	Iron	0-4	microtubule associated protein tau	Homo sapiens	120-123
33796002-7	2021	Iron accumulation may affect long-term cognitive dysfunction from three pathways: local injury, iron deposition induces tau phosphorylation, the formation of neurofibrillary tangles; neural cells death; and neural network damage, iron deposition leads to axonal injury by utilizing the iron sensibility of oligodendrocytes.	Iron	96-100	microtubule associated protein tau	Homo sapiens	120-123
33868836-2	2021	The salient features of beta thalassemia major, in which both alleles of the HBB gene are affected, are transfusion dependency and iron overload.	Iron	131-135	hemoglobin subunit beta	Homo sapiens	77-80
33385755-0	2021	Functional characterization of a novel SLC40A1 Arg88Ile mutation in a kindred with familial iron overload treated by phlebotomy.	Iron	92-96	solute carrier family 40 member 1	Homo sapiens	39-46
33486765-2	2021	Erythroferrone (ERFE) and growth/differentiation factor 15 (GDF15) are two regulators of iron homeostasis produced by erythroid progenitors.	Iron	89-93	erythroferrone	Homo sapiens	16-20
33486765-3	2021	Elevated systemic levels of ERFE and GDF15 in MDS are associated with dysregulated iron metabolism and iron overload, which is especially pronounced in MDS with SF3B1 gene mutations.	Iron	83-87	erythroferrone	Homo sapiens	28-32
33408127-9	2021	In addition, we found that systemic iron overload promotes gluconeogenesis by activating hepatic PKA Foxo1 axis.	Iron	36-40	forkhead box O1	Mus musculus	101-106
35118832-9	2022	RESULTS: In vitro, iron exposure caused dose-dependent increases of iron storage protein ferritin (P < 0.01) and dose-dependent decreases of mRNA TfR1 levels (P < 0.001), which support cellular adaptations to iron excess.	Iron	209-213	transferrin receptor	Mus musculus	146-150
32607777-3	2021	SLC40A1 encodes ferroportin, a macromolecule only known as iron exporter from mammalian cells.	Iron	59-63	solute carrier family 40 member 1	Homo sapiens	0-7
35118832-12	2022	In vivo, basal iron content and mRNA TfR1 levels were significantly higher in the soleus compared with the gastrocnemius (+130% and +127%; P < 0.001, respectively), supporting higher iron needs in oxidative skeletal muscle.	Iron	183-187	transferrin receptor	Mus musculus	37-41
35182697-1	2022	Ferroptosis is an iron-dependent form of regulated cell death, which is driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid peroxidation.	Iron	18-22	glutathione peroxidase 4	Rattus norvegicus	126-150
35182697-1	2022	Ferroptosis is an iron-dependent form of regulated cell death, which is driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid peroxidation.	Iron	18-22	glutathione peroxidase 4	Rattus norvegicus	152-156
33634543-8	2021	High certainty evidence from meta-analyses demonstrated improved HRQoL over placebo with sodium-glucose co-transporter 2 (SGLT2) inhibitors [standardized mean difference (SMD) 0.16, 95% confidence interval (CI) 0.08-0.23] and intravenous iron (SMD 0.52, 95% CI 0.04-1.00).	Iron	238-242	solute carrier family 5 member 2	Homo sapiens	122-127
35182697-8	2022	The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4.	Iron	111-115	transferrin receptor	Rattus norvegicus	144-164
35410912-8	2022	Biomarkers for iron stores (serum ferritin and serum transferrin receptor) was analysed from frozen blood samples in 2014.	Iron	15-19	transferrin receptor	Homo sapiens	53-73
33620584-2	2021	Recently, artemisinin (ART) and its derivatives have been investigated as potential anticancer agents for the treatment of highly aggressive cancers via the induction of ferroptosis by iron-mediated cleavage of the endoperoxide bridge.	Iron	185-189	artemin	Homo sapiens	23-26
35365951-3	2022	NRAMP6 was demonstrated to regulate cadmium tolerance and iron utilization in Arabidopsis.	Iron	58-62	NRAMP metal ion transporter 6	Arabidopsis thaliana	0-6
33631196-7	2021	Our results revealed that 1) IRP/IRE interaction was increased in proportional to the thermogenic function of the adipose depot, 2) adipose iron content was increased in adipose tissue browning upon beta3-adrenoceptor stimulation, while decreased in thermoneutral conditions, and 3) modulation of iron content was linked with mitochondrial biogenesis.	Iron	140-144	adrenoceptor beta 3	Homo sapiens	199-217
33631196-7	2021	Our results revealed that 1) IRP/IRE interaction was increased in proportional to the thermogenic function of the adipose depot, 2) adipose iron content was increased in adipose tissue browning upon beta3-adrenoceptor stimulation, while decreased in thermoneutral conditions, and 3) modulation of iron content was linked with mitochondrial biogenesis.	Iron	297-301	adrenoceptor beta 3	Homo sapiens	199-217
35407917-0	2022	Improving the Shape Memory Effect of a Fe-Mn-Si-Cr-Ni Alloy through Shot Peening.	Iron	39-41	short stature homeobox 2	Homo sapiens	68-72
33450374-6	2021	In accordance with iron-replete condition, proteins involved in iron uptake, transport and storage including divalent metal ion transporter 1 (DMT1), transferrin receptor 1 (TFR1), ferritin, poly(rC)-binding proteins 1 and 2 (PCBP1 and 2) and nuclear factor E2-related factor 2 (NRF2) all increase in ovarian cancer spheroids.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	143-147
33571427-0	2021	A role of PIEZO1 in iron metabolism in mice and humans.	Iron	20-24	piezo-type mechanosensitive ion channel component 1	Mus musculus	10-16
33571427-4	2021	Individuals with hereditary xerocytosis, a rare disorder with gain-of-function (GOF) mutations in mechanosensitive PIEZO1 ion channel, develop age-onset iron overload.	Iron	153-157	piezo-type mechanosensitive ion channel component 1	Mus musculus	115-121
35346040-9	2022	Furthermore, in mnb1 mutants, the transcription level of the Fe uptake- and translocation-related genes, FIT, IRT1, FRO2, ZIF, FRD3, NAS4, PYE and MYB72, were considerably elevated during Fe-deficiency stress, resulting in enhanced Fe uptake and translocation, thereby increasing Fe accumulation.	Iron	61-63	ferric reduction oxidase 2	Arabidopsis thaliana	116-120
33571427-5	2021	We show that constitutive or macrophage expression of a GOF Piezo1 allele in mice disrupts levels of the iron regulator hepcidin and causes iron overload.	Iron	105-109	piezo-type mechanosensitive ion channel component 1	Mus musculus	60-66
33571427-5	2021	We show that constitutive or macrophage expression of a GOF Piezo1 allele in mice disrupts levels of the iron regulator hepcidin and causes iron overload.	Iron	140-144	piezo-type mechanosensitive ion channel component 1	Mus musculus	60-66
33571427-7	2021	Strikingly, we find that E756del, a mild GOF PIEZO1 allele present in one-third of individuals of African descent, is strongly associated with increased plasma iron.	Iron	160-164	piezo-type mechanosensitive ion channel component 1	Mus musculus	45-51
35346040-9	2022	Furthermore, in mnb1 mutants, the transcription level of the Fe uptake- and translocation-related genes, FIT, IRT1, FRO2, ZIF, FRD3, NAS4, PYE and MYB72, were considerably elevated during Fe-deficiency stress, resulting in enhanced Fe uptake and translocation, thereby increasing Fe accumulation.	Iron	61-63	nicotianamine synthase 4	Arabidopsis thaliana	133-137
35338371-0	2022	Experimental Research on Vortex Melting Reduction of High-Iron Red Mud (Bauxite Residue).	Iron	58-62	adaptor related protein complex 5 subunit mu 1	Homo sapiens	67-70
33670778-12	2021	Our observations indicate that the butyrylcholinesterase (BChE) level seems to be iron-dependent, and reports show that BChE produced by reactive astrocytes can make cognitive functions worse by accelerating the decay of acetylcholine in aging brains.	Iron	82-86	butyrylcholinesterase	Homo sapiens	58-62
33670778-12	2021	Our observations indicate that the butyrylcholinesterase (BChE) level seems to be iron-dependent, and reports show that BChE produced by reactive astrocytes can make cognitive functions worse by accelerating the decay of acetylcholine in aging brains.	Iron	82-86	butyrylcholinesterase	Homo sapiens	120-124
35338371-3	2022	The effects of different adding methods, stirring speed and reaction time on iron recovery were investigated by using red mud, aluminum leached slag and calcified slag as raw materials.	Iron	77-81	adaptor related protein complex 5 subunit mu 1	Homo sapiens	122-125
33593088-1	2021	Chronic, systemic inflammation, which is associated with obesity and numerous other diseases, impairs iron status by increasing hepcidin concentration.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	128-136
35338371-5	2022	The results provided an experimental basis for the harmless and high-value utilization of high-iron red mud treated by vortex melting reduction.	Iron	95-99	adaptor related protein complex 5 subunit mu 1	Homo sapiens	104-107
35324298-3	2022	We report the isolation and x-ray crystallographic characterization of a mononuclear iron complex featuring P2 coordination in a side-on, eta2-binding mode.	Iron	85-89	DNA polymerase iota	Homo sapiens	138-142
33594527-4	2022	Mitochondrial ferritin (FtMt) is a protein that stores iron ions and intercepts toxic ferrous ions in cells mitochondria.	Iron	55-59	ferritin mitochondrial	Homo sapiens	0-22
33594527-4	2022	Mitochondrial ferritin (FtMt) is a protein that stores iron ions and intercepts toxic ferrous ions in cells mitochondria.	Iron	55-59	ferritin mitochondrial	Homo sapiens	24-28
35324298-4	2022	An analogous eta2-bound bis-timethylsilylacetylene iron complex is reported for comparison.	Iron	51-55	DNA polymerase iota	Homo sapiens	13-17
35324298-5	2022	Nuclear magnetic resonance, infrared, and Mossbauer spectroscopic analysis-in conjunction with density functional theory calculations-demonstrate that eta2-P2 and eta2-acetylene ligands exert a similar electronic demand on mononuclear iron centers but exhibit different reactivity profiles.	Iron	235-239	DNA polymerase iota	Homo sapiens	151-155
33668657-3	2021	In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	105-113
33668657-3	2021	In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	105-113
35324298-5	2022	Nuclear magnetic resonance, infrared, and Mossbauer spectroscopic analysis-in conjunction with density functional theory calculations-demonstrate that eta2-P2 and eta2-acetylene ligands exert a similar electronic demand on mononuclear iron centers but exhibit different reactivity profiles.	Iron	235-239	DNA polymerase iota	Homo sapiens	163-167
34982827-6	2022	Decreased reductase activity resulted in increased transcripts for iron acquisition proteins DMT1 and Tfrc1 suggesting cells were iron limited.	Iron	130-134	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	93-97
35299258-0	2022	Optical assay using B-doped core-shell Fe@BC nanozyme for determination of alanine aminotransferase.	Iron	39-41	glutamic--pyruvic transaminase	Homo sapiens	75-99
33567510-1	2021	The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	20-28
33567510-1	2021	The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	20-28
33567510-1	2021	The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	20-28
33567510-2	2021	Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which reduces both iron absorption in the gut and export of iron from storage to ultimately decrease systemic iron levels.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	0-8
33567510-2	2021	Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which reduces both iron absorption in the gut and export of iron from storage to ultimately decrease systemic iron levels.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	0-8
33567510-2	2021	Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which reduces both iron absorption in the gut and export of iron from storage to ultimately decrease systemic iron levels.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	0-8
35143157-2	2022	To further identify more potent ferroptosis inhibitors and effective targets for treating TBI, our study aims at investigating the effects of TfR1 on ferroptosis in a mouse TBI model using ferristatin II (an iron uptake and TfR1 inhibitor).	Iron	208-212	transferrin receptor	Mus musculus	142-146
33373218-4	2021	With X-ray crystallography, we detected an unexpected photochemical intermediate trapped in a crystal of the hIDO1-CO-Trp complex, where CO is photolyzed from the heme iron by X-rays at cryogenic temperatures (100 K).	Iron	168-172	indoleamine 2,3-dioxygenase 1	Homo sapiens	109-114
33395292-8	2021	Other typical fragment-ions produced from protonated metallocenes included the M(cp)1+ ions (M = Fe or Ni), by elimination of a cyclopentadiene molecule, or the molecular cation, by loss of a H  radical.	Iron	97-99	C-C motif chemokine ligand 2	Homo sapiens	79-85
35310092-4	2022	FXN is a mitochondrial protein involved in iron metabolism but its exact function has remained elusive and highly debated since its discovery.	Iron	43-47	frataxin	Homo sapiens	0-3
32348689-3	2021	Lactoferrin is an iron-binding glycoprotein found in the milk of most mammals with broad spectrum antimicrobial activities, including against the related murine norovirus in cell culture.	Iron	18-22	lactotransferrin	Bos taurus	0-11
35310092-5	2022	At the cellular level, FRDA is characterized by a general deficit in the biosynthesis of iron-sulfur (Fe-S) clusters and heme, iron accumulation and deposition in mitochondria, and sensitivity to oxidative stress.	Iron	102-106	frataxin	Homo sapiens	23-27
35090880-6	2022	Knockdown of SSAT1 mitigated I/R-induced cerebral infarction and neurological impairments, as well as decreased cortical iron contents, reactive oxygen species (ROS) generation and 4-Hydroxynonenal (4-HNE) level.	Iron	121-125	spermidine/spermine N1-acetyl transferase 1	Mus musculus	13-18
33535496-5	2021	This review explores our current understanding of iron homeostasis in cancer, shedding light on the modulatory role of hepcidin in intestinal iron absorption, iron recycling, mobilization from liver deposits, and inducible regulators by infections and inflammation.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	119-127
33535496-5	2021	This review explores our current understanding of iron homeostasis in cancer, shedding light on the modulatory role of hepcidin in intestinal iron absorption, iron recycling, mobilization from liver deposits, and inducible regulators by infections and inflammation.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	119-127
33535496-5	2021	This review explores our current understanding of iron homeostasis in cancer, shedding light on the modulatory role of hepcidin in intestinal iron absorption, iron recycling, mobilization from liver deposits, and inducible regulators by infections and inflammation.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	119-127
35297184-3	2022	Detailed XPS spectra and DFT calculations confirm the formation of carbon-iron bonds in HNG-ethanol during synthesis process, which act as electron transport channels from graphene to Hemin.	Iron	74-78	neurogranin	Homo sapiens	88-91
35133148-0	2022	Iron Activates cGAS-STING Signaling and Promotes Hepatic Inflammation.	Iron	0-4	stimulator of interferon response cGAMP interactor 1	Homo sapiens	20-25
32780358-7	2021	Thus, based on the obtained results, the expression of c-kit, STRA8, and PCNA genes was significantly increased in treatment groups by curcumin-loaded iron particles compared with scrotal hyperthermia-induced mice.	Iron	151-155	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	55-60
32780358-7	2021	Thus, based on the obtained results, the expression of c-kit, STRA8, and PCNA genes was significantly increased in treatment groups by curcumin-loaded iron particles compared with scrotal hyperthermia-induced mice.	Iron	151-155	stimulated by retinoic acid gene 8	Mus musculus	62-67
35133148-3	2022	We demonstrated that iron treatment enhanced the expression of cGAS, STING, and their downstream targets, including TBK1, IRF-3, and NF-kappaB in HepG2 cells and mice liver.	Iron	21-25	stimulator of interferon response cGAMP interactor 1	Homo sapiens	69-74
33491917-2	2021	BACKGROUND: Iron featured historically early in AD research efforts for its involvement in the amyloid and tau proteinopathies, APP processing, genetics, and one clinical trial, yet iron neurochemistry remains peripheral in mainstream AD research.	Iron	12-16	microtubule associated protein tau	Homo sapiens	107-110
33491917-11	2021	LINKAGE TO OTHER MAJOR THEORIES: Iron has historically been linked to the amyloid and tau proteinopathies of AD.	Iron	33-37	microtubule associated protein tau	Homo sapiens	86-89
35133148-3	2022	We demonstrated that iron treatment enhanced the expression of cGAS, STING, and their downstream targets, including TBK1, IRF-3, and NF-kappaB in HepG2 cells and mice liver.	Iron	21-25	interferon regulatory factor 3	Homo sapiens	122-127
35181698-4	2022	We show that absorption of iron from FePO4-NP appears to be largely DMT1 dependent and that its biodistribution after absorption is similar to that from FeSO4, without abnormal deposition of iron in the reticuloendothelial system.	Iron	27-31	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	68-72
33491917-12	2021	Tau, APP, and apoE have been implicated in physiological iron homeostasis in the brain.	Iron	57-61	microtubule associated protein tau	Homo sapiens	0-3
35221903-3	2022	Frataxin function, although not thoroughly elucidated, is associated with assembly of iron-sulfur cluster and iron metabolism, therefore insufficient frataxin levels lead to reduced activity of many mitochondrial enzymes involved in the electron transport chain, impaired mitochondrial metabolism, reduced ATP production and inefficient anti-oxidant response.	Iron	86-90	frataxin	Homo sapiens	0-8
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Iron	232-236	cytochrome p450 oxidoreductase	Mus musculus	47-78
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Iron	232-236	cytochrome p450 oxidoreductase	Mus musculus	80-83
33321093-2	2021	We report here that oxidoreductases, including NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1), transfer electrons from NAD(P)H to oxygen to generate hydrogen peroxide, which subsequently reacts with iron to generate reactive hydroxyl radicals for the peroxidation of the polyunsaturated fatty acid (PUFA) chains of membrane phospholipids, thereby disrupting membrane integrity during ferroptosis.	Iron	232-236	cytochrome b5 reductase 1	Mus musculus	119-125
33285139-3	2021	Iron deprivation from erythroblasts and other tissues occurs when total body stores of iron are low or when inflammation causes withholding of iron from the plasma, particularly through the action of hepcidin, the main regulator of systemic iron homoeostasis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	200-208
33285139-3	2021	Iron deprivation from erythroblasts and other tissues occurs when total body stores of iron are low or when inflammation causes withholding of iron from the plasma, particularly through the action of hepcidin, the main regulator of systemic iron homoeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	200-208
33285139-3	2021	Iron deprivation from erythroblasts and other tissues occurs when total body stores of iron are low or when inflammation causes withholding of iron from the plasma, particularly through the action of hepcidin, the main regulator of systemic iron homoeostasis.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	200-208
33285139-3	2021	Iron deprivation from erythroblasts and other tissues occurs when total body stores of iron are low or when inflammation causes withholding of iron from the plasma, particularly through the action of hepcidin, the main regulator of systemic iron homoeostasis.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	200-208
33285139-5	2021	Hepcidin upregulation by oral iron supplementation limits the absorption efficiency of high-dose oral iron supplementation, and of oral iron during inflammation.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
33285139-5	2021	Hepcidin upregulation by oral iron supplementation limits the absorption efficiency of high-dose oral iron supplementation, and of oral iron during inflammation.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	0-8
35221903-3	2022	Frataxin function, although not thoroughly elucidated, is associated with assembly of iron-sulfur cluster and iron metabolism, therefore insufficient frataxin levels lead to reduced activity of many mitochondrial enzymes involved in the electron transport chain, impaired mitochondrial metabolism, reduced ATP production and inefficient anti-oxidant response.	Iron	86-90	frataxin	Homo sapiens	150-158
33285139-5	2021	Hepcidin upregulation by oral iron supplementation limits the absorption efficiency of high-dose oral iron supplementation, and of oral iron during inflammation.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	0-8
35221903-3	2022	Frataxin function, although not thoroughly elucidated, is associated with assembly of iron-sulfur cluster and iron metabolism, therefore insufficient frataxin levels lead to reduced activity of many mitochondrial enzymes involved in the electron transport chain, impaired mitochondrial metabolism, reduced ATP production and inefficient anti-oxidant response.	Iron	110-114	frataxin	Homo sapiens	0-8
35221903-3	2022	Frataxin function, although not thoroughly elucidated, is associated with assembly of iron-sulfur cluster and iron metabolism, therefore insufficient frataxin levels lead to reduced activity of many mitochondrial enzymes involved in the electron transport chain, impaired mitochondrial metabolism, reduced ATP production and inefficient anti-oxidant response.	Iron	110-114	frataxin	Homo sapiens	150-158
35377584-2	2022	Three cysteine desulfurases, IscS, NifS, and SufS, have been identified in ISC, NIF, and SUF/SUF-like systems for iron-sulfur (Fe-S) cluster biosynthesis, respectively.	Iron	127-131	NFS1 cysteine desulfurase	Homo sapiens	35-39
33441545-4	2021	We detected that iron deposition was clearly increased in a time-dependent manner from 1 to 17 months in the substantia nigra and globus pallidus, highly contrasting to other brain regions after treatments with alpha-syn PFFs.	Iron	17-21	synuclein alpha	Homo sapiens	211-220
33441545-5	2021	At the cellular level, the iron deposits were specifically localized in microglia but not in dopaminergic neurons, nor in other types of glial cells in the substantia nigra, whereas the expression of transferrin (TF), TF receptor 1 (TFR1), TF receptor 2 (TFR2), and ferroportin (FPn) was increased in dopaminergic neurons.	Iron	27-31	transferrin receptor protein 2	Macaca fascicularis	255-259
33441545-7	2021	The brain region-enriched and cell-type-dependent iron localizations indicate that the intranasal alpha-syn PFFs treatment-induced iron depositions in microglia in the substantia nigra may appear as an early cellular response that may initiate neuroinflammation in the dopaminergic system before cell death occurs.	Iron	50-54	synuclein alpha	Homo sapiens	98-107
33441545-7	2021	The brain region-enriched and cell-type-dependent iron localizations indicate that the intranasal alpha-syn PFFs treatment-induced iron depositions in microglia in the substantia nigra may appear as an early cellular response that may initiate neuroinflammation in the dopaminergic system before cell death occurs.	Iron	131-135	synuclein alpha	Homo sapiens	98-107
35029613-6	2022	A core mechanism for the iron-catalyzed decomposition of H2O2 is proposed that is consistent with the principle of detailed balancing and includes both the one-electron oxidation of H2O2 by Fe(III) and the Fe(II) reduction of HO2 .	Iron	25-29	heme oxygenase 2	Homo sapiens	226-229
33469287-7	2021	It also facilitated the downregulation of GPX4 and xCT, ultimately resulting in iron-dependent oxidative death.	Iron	80-84	glutathione peroxidase 4	Homo sapiens	42-46
33469287-7	2021	It also facilitated the downregulation of GPX4 and xCT, ultimately resulting in iron-dependent oxidative death.	Iron	80-84	solute carrier family 7 member 11	Homo sapiens	51-54
35099573-9	2022	These results provide further insight into the proposed mechanisms for iron regulation in yeasts especially as these productions strains contain a mutant allele of the iron regulator, mga2.	Iron	71-75	Mga2p	Saccharomyces cerevisiae S288C	184-188
33585112-2	2021	The cart sped up and he lost control and toppled in front of the iron wheel, which ran over his lower limb around the knee.	Iron	65-69	RAN, member RAS oncogene family	Homo sapiens	83-86
35099573-9	2022	These results provide further insight into the proposed mechanisms for iron regulation in yeasts especially as these productions strains contain a mutant allele of the iron regulator, mga2.	Iron	168-172	Mga2p	Saccharomyces cerevisiae S288C	184-188
35001811-3	2022	Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act as positive regulators of PRKN-independent mitophagy.	Iron	6-10	protein kinase C delta	Homo sapiens	171-176
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	101-105	integrin subunit alpha L	Homo sapiens	222-227
33490642-1	2021	Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation.	Iron	69-73	solute carrier family 40 member 1	Homo sapiens	17-22
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	122-126	integrin subunit alpha L	Homo sapiens	222-227
33490642-1	2021	Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation.	Iron	69-73	solute carrier family 40 member 1	Homo sapiens	23-27
33490642-1	2021	Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation.	Iron	148-152	solute carrier family 40 member 1	Homo sapiens	17-22
34320783-8	2022	The results suggest that the E1 enzyme UBA6 and the adaptor protein NDFIP1 are involved in iron homeostasis by regulating the degradation of ferroportin.	Iron	91-95	Nedd4 family interacting protein 1	Mus musculus	68-74
33490642-1	2021	Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation.	Iron	148-152	solute carrier family 40 member 1	Homo sapiens	23-27
33419006-4	2021	Hepcidin is a small cationic peptide with a central role in regulating systemic iron homeostasis.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
33419006-5	2021	Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1).	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	47-55
33419006-5	2021	Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1).	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	47-55
33419006-5	2021	Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1).	Iron	106-110	solute carrier family 40 member 1	Homo sapiens	187-200
35340277-7	2022	Our suggested elucidated pathological sequence is: a) spike protein subunit S1 docking with sialylated membrane glycoproteins/receptors (ACE2, CD147), and S2 subunit fusion with the lipid layer; b) cell membrane morpho-functional changes due to the consequent electro-chemical variations and viroporin action, which induce an altered ion channel function and intracellular cation accumulation; c) additional intracellular iron concentration due to a deregulated hepcidin-ferroportin axis, with higher hepcidin levels.	Iron	422-426	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	54-59
33419006-5	2021	Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1).	Iron	106-110	solute carrier family 40 member 1	Homo sapiens	202-206
35118074-4	2021	We identified the prognostic value of two iron metabolism-related genes (SLC39A8 (encoding solute carrier family 39 member 8) and SLC48A1 (encoding solute carrier family 48 member 1)) in COAD.	Iron	42-46	solute carrier family 39 member 8	Homo sapiens	73-80
32980338-1	2021	Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments concerning their functional properties.	Iron	110-112	thioredoxin	Homo sapiens	10-21
35118074-4	2021	We identified the prognostic value of two iron metabolism-related genes (SLC39A8 (encoding solute carrier family 39 member 8) and SLC48A1 (encoding solute carrier family 48 member 1)) in COAD.	Iron	42-46	solute carrier family 39 member 8	Homo sapiens	91-124
35101795-0	2022	The NtNRAMP1 transporter is involved in cadmium and iron transport in tobacco (Nicotiana tabacum).	Iron	52-56	metal transporter Nramp6-like	Nicotiana tabacum	4-12
35101795-7	2022	To reveal the characteristics of NtNRAMP1 in metal transport, transgenic plants were cultured in hydroponic solution with 50 muM Cd and 200 muM Fe.	Iron	144-146	metal transporter Nramp6-like	Nicotiana tabacum	33-41
35101795-10	2022	Overexpression of NtNRAMP1 did not promote Fe uptake from the external environment into the roots but enhanced the transfer of Fe from the roots to shoots.	Iron	127-129	metal transporter Nramp6-like	Nicotiana tabacum	18-26
35101795-12	2022	In conclusion, overexpression of NtNRAMP1 in tobacco could promote Cd uptake and Fe transport from the roots to shoots while disturbing Fe homeostasis in the leaves of transgenic tobacco.	Iron	81-83	metal transporter Nramp6-like	Nicotiana tabacum	33-41
35101795-12	2022	In conclusion, overexpression of NtNRAMP1 in tobacco could promote Cd uptake and Fe transport from the roots to shoots while disturbing Fe homeostasis in the leaves of transgenic tobacco.	Iron	136-138	metal transporter Nramp6-like	Nicotiana tabacum	33-41
35096573-15	2021	GO and KEGG pathway enrichment analysis revealed that ACADSB-related genes were significantly enriched in categories related to FA metabolism, branched-chain amino acid (BCAA) metabolism, and iron regulation.	Iron	192-196	acyl-CoA dehydrogenase short/branched chain	Homo sapiens	54-60
35069934-6	2022	HSF1 was knockdown in MES-SA and FU-MMT-1 cells, and cell viability, lipid ROS, and intracellular iron level were detected when combined with doxorubicin or gemcitabine.	Iron	98-102	heat shock transcription factor 1	Homo sapiens	0-4
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	polo kinase CDC5	Saccharomyces cerevisiae S288C	209-213
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	serine/threonine protein kinase DUN1	Saccharomyces cerevisiae S288C	215-219
2605266-2	1989	We have determined that the major iron-binding and DNA-binding protein in porcine colostral whey is lactoferrin.	Iron	34-38	lactotransferrin	Bos taurus	100-111
32841622-1	2021	As a member of natural resistance-associated macrophage protein (Nramp) family, Nramp2 conservatively exists in the cell membrane across species and is essential for normal iron homeostasis in an H+-dependent manner.	Iron	173-177	solute carrier family 11 member 2	Homo sapiens	80-86
33210733-7	2021	However, the absence of classical coordination to the iron atom leaves the possibility that the primary ligand of Blc is another tetrapyrrole.	Iron	54-58	outer membrane lipoprotein Blc	Escherichia coli	114-117
33683041-1	2021	BACKGROUND AND OBJECTIVE: Hepcidin, a key element in iron hemostasis, is a small antimicrobial peptide encoded by the HAMP gene on 19q13.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	118-122
33683041-3	2021	Therefore, this research aimed to study the frequency distribution of HAMP promoter genetic variants and their associations with serum iron, serum transferrin and serum ferritin levels in Saudi Arabian women (aged 15-25).	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	70-74
33683041-8	2021	RESULTS: The frequencies of HAMP promoter rs10421768 genotypes AA, AG and GG were 3.45, 96.55 and 0% in the iron-deficient women and 12, 88 and 0% in the healthy women, respectively.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	28-32
33683041-9	2021	The distributions of the HAMP promoter c.-582 A>G genotypes observed between the iron-deficient and normal women were not significantly different (p = 0.239).	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	25-29
33683041-10	2021	A significant difference in the HAMP genotype (c.-582 A>G) between the iron-deficient women and healthy women was associated with reduced serum iron (p = 0.049).	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	32-36
33683041-10	2021	A significant difference in the HAMP genotype (c.-582 A>G) between the iron-deficient women and healthy women was associated with reduced serum iron (p = 0.049).	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	32-36
33683041-11	2021	CONCLUSION: The results indicated that the HAMP genotype (c.-582 A>G) was associated with reduced serum iron in women in northern Saudi Arabia.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	43-47
33396831-3	2020	Ferroportin (Fpn), the only known cellular iron exporter, as well as hephaestin (Heph) and ceruloplasmin, two copper-dependent ferroxidases involved in the above-mentioned processes, are key elements of the interaction between copper and iron metabolisms.	Iron	238-242	ceruloplasmin	Homo sapiens	91-104
33122194-4	2020	Yeast two-hybrid and bimolecular fluorescence complementation studies demonstrated interaction of both the NFU4 and NFU5 proteins with the ISCA class of Fe-S carrier proteins.	Iron	153-157	NFU domain protein 4	Arabidopsis thaliana	107-111
33122194-5	2020	Recombinant NFU4 and NFU5 were purified as apo-proteins after expression in Escherichia coli In vitro Fe-S cluster reconstitution led to the insertion of one [4Fe-4S]2+ cluster per homodimer as determined by UV-visible absorption/CD, resonance Raman and EPR spectroscopy, and analytical studies.	Iron	102-106	NFU domain protein 4	Arabidopsis thaliana	12-16
33392212-5	2020	Hepcidin-ferroportin axis has a central role in regulating body iron balance and coordinating communication between tissues and cells that acquire, store, and utilize iron.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
33392212-5	2020	Hepcidin-ferroportin axis has a central role in regulating body iron balance and coordinating communication between tissues and cells that acquire, store, and utilize iron.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	0-8
33334885-4	2021	The findings revealed that the proton-coupled amino acid transporter SLC36A1 (PAT1) transports iron in the form of NA-Fe (II) complex in vitro Decreased expression of hPAT1 by RNA interference in Caco-2 cells reduced the uptake of NA-59Fe (II) complex.	Iron	95-99	solute carrier family 36 member 1	Homo sapiens	69-76
33334885-4	2021	The findings revealed that the proton-coupled amino acid transporter SLC36A1 (PAT1) transports iron in the form of NA-Fe (II) complex in vitro Decreased expression of hPAT1 by RNA interference in Caco-2 cells reduced the uptake of NA-59Fe (II) complex.	Iron	95-99	solute carrier family 36 member 1	Homo sapiens	78-82
33334885-4	2021	The findings revealed that the proton-coupled amino acid transporter SLC36A1 (PAT1) transports iron in the form of NA-Fe (II) complex in vitro Decreased expression of hPAT1 by RNA interference in Caco-2 cells reduced the uptake of NA-59Fe (II) complex.	Iron	95-99	solute carrier family 36 member 1	Homo sapiens	167-172
33348847-2	2020	Running exercise is known to acutely increase hepcidin levels, which reduces iron absorption and recycling.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	46-54
33051205-1	2020	Heme oxygenase-2 (HO2) and -1 (HO1) catalyze heme degradation to biliverdin, CO, and iron, forming an essential link in the heme metabolism network.	Iron	85-89	heme oxygenase 1	Homo sapiens	31-34
33311482-3	2020	We find that either high-iron diets or Gpx4 depletion promotes 8-OHG release and thus activates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltration and activation during Kras-driven PDAC in mice.	Iron	25-29	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	207-211
32886113-0	2020	Iron Absorption is Greater from Apo-Lactoferrin and is Similar Between Holo-Lactoferrin and Ferrous Sulfate: Stable Iron Isotope Studies in Kenyan Infants.	Iron	0-4	aminopeptidase O (putative)	Homo sapiens	32-35
32886113-6	2020	The iron saturation levels of apo- and holo-Lf were 0.56% and 47.26%, respectively primary outcome was fractional iron absorption (FIA), assessed by erythrocyte incorporation of isotopic labels.	Iron	4-8	aminopeptidase O (putative)	Homo sapiens	30-33
32886113-9	2020	CONCLUSIONS: The amount of iron absorbed from holo-Lf was comparable to that of FeSO4, and the addition of apo-Lf to a test meal containing FeSO4 significantly increased (+56%) iron absorption.	Iron	177-181	aminopeptidase O (putative)	Homo sapiens	107-110
33231049-3	2020	The reticulocyte hemoglobin equivalent (RET-He) is a marker that is not altered by inflammatory conditions and directly reflects iron availability in the bone marrow.	Iron	129-133	ret proto-oncogene	Homo sapiens	40-43
32720070-0	2020	Augmenting the expression of accD and rbcL genes using optimized iron concentration to achieve higher biomass and biodiesel in Chlorella vulgaris.	Iron	65-69	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Chlorella vulgaris	38-42
32720070-7	2020	The expression of genes corresponding to the metabolic enzymes (i.e. acetyl-CoA carboxylase (accD) and ribulose bisphosphate carboxylase large chain (rbcL)) was evaluated using real-time PCR under different initial iron feeds.	Iron	215-219	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Chlorella vulgaris	150-154
32720070-9	2020	In 90 microM initial iron concentration, the expression of accD and rbcL genes showed a 4.8- and 35-fold increase, respectively, compared to that of the control genes.	Iron	21-25	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Chlorella vulgaris	68-72
32827218-0	2020	Leishmania infection triggers hepcidin-mediated proteasomal degradation of Nramp1 to increase phagolysosomal iron availability.	Iron	109-113	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	75-81
32827218-8	2020	Blocking of Nramp1 degradation with proteasome inhibitor or transcriptional agonist of hepcidin resulted in depletion of phagolysosomal iron pool that led to significant reduction of intracellular parasite burden.	Iron	136-140	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	12-18
32827218-9	2020	Interestingly, Nramp1 level was restored to normalcy after 30 hours of infection with a concomitant drop in phagolysosomal iron, which is suggestive of a host counteractive response to deprive the pathogen of this essential micronutrient.	Iron	123-127	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	15-21
32827218-10	2020	Taken together, our study implicates Nramp1 as a central player in the host-pathogen battle for phagolysosomal iron.	Iron	111-115	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	37-43
32827218-11	2020	We also report Nramp1 as a novel target for hepcidin and this "hepcidin-Nramp1" axis may have a broader role in regulating macrophage iron homeostasis.	Iron	134-138	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	15-21
32827218-11	2020	We also report Nramp1 as a novel target for hepcidin and this "hepcidin-Nramp1" axis may have a broader role in regulating macrophage iron homeostasis.	Iron	134-138	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	72-78
32763792-5	2020	The bismuth titanate supported, iron-chelated thermoresponsive polymer brushes showed selective binding for phosphoproteins in the presence of abundant interfering proteins, and a high binding capacity for phosphoproteins by virtue of the metal affinity between the metal ions on the polymer brushes and the phosphate groups in the phosphoproteins (664 mg beta-Casein per g sorbent).	Iron	32-36	casein beta	Homo sapiens	356-367
31838956-0	2020	Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients.	Iron	10-14	signal transducer and activator of transcription 5A	Homo sapiens	40-45
31838956-1	2020	Objectives: Background/aims: We aim to explore low-risk MDS patients" ESA response and the difference between iron-overloaded (IO) group and the control group in the expression of SOCS1, STAT5 and BCL2L1 which play a key role to EPO-STAT5 signal pathway.Methods: 56 low-risk MDS patients were divided into experimental group, IO patients; control group, non-IO patients.	Iron	110-114	suppressor of cytokine signaling 1	Homo sapiens	180-185
31838956-1	2020	Objectives: Background/aims: We aim to explore low-risk MDS patients" ESA response and the difference between iron-overloaded (IO) group and the control group in the expression of SOCS1, STAT5 and BCL2L1 which play a key role to EPO-STAT5 signal pathway.Methods: 56 low-risk MDS patients were divided into experimental group, IO patients; control group, non-IO patients.	Iron	110-114	signal transducer and activator of transcription 5A	Homo sapiens	187-192
33035800-2	2020	Rep1 polymorphism in the promotor region of SNCA is associated with risk of Parkinson"s disease, however its association with RLS and iron status is unclear.	Iron	134-138	synuclein alpha	Homo sapiens	44-48
33057935-2	2020	Athletes" ability to replenish taxed iron stores is challenging due to the low bioavailability of dietary sources, and the interaction between exercise and hepcidin, the primary iron-regulatory hormone.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	156-164
32776106-1	2020	NFU1, a late acting iron-sulfur (Fe-S) cluster carrier protein, has a key role in the pathogenesis of the disease Multiple Mitochondrial Dysfunctions Syndrome (MMDS1).	Iron	20-24	NFU1 iron-sulfur cluster scaffold	Homo sapiens	0-4
32776106-1	2020	NFU1, a late acting iron-sulfur (Fe-S) cluster carrier protein, has a key role in the pathogenesis of the disease Multiple Mitochondrial Dysfunctions Syndrome (MMDS1).	Iron	20-24	NFU1 iron-sulfur cluster scaffold	Homo sapiens	160-165
32776106-1	2020	NFU1, a late acting iron-sulfur (Fe-S) cluster carrier protein, has a key role in the pathogenesis of the disease Multiple Mitochondrial Dysfunctions Syndrome (MMDS1).	Iron	33-35	NFU1 iron-sulfur cluster scaffold	Homo sapiens	0-4
32776106-1	2020	NFU1, a late acting iron-sulfur (Fe-S) cluster carrier protein, has a key role in the pathogenesis of the disease Multiple Mitochondrial Dysfunctions Syndrome (MMDS1).	Iron	33-35	NFU1 iron-sulfur cluster scaffold	Homo sapiens	160-165
32776106-2	2020	In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the secondary carrier, ISCA1, as the direct donors of Fe-S clusters to mitochondrial NFU1, which appears to dimerize and reductively mediate formation of a bridging [4Fe-4S] cluster, aided by ferredoxin 2 (FDX2).	Iron	185-187	NFU1 iron-sulfur cluster scaffold	Homo sapiens	216-220
32776106-2	2020	In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the secondary carrier, ISCA1, as the direct donors of Fe-S clusters to mitochondrial NFU1, which appears to dimerize and reductively mediate formation of a bridging [4Fe-4S] cluster, aided by ferredoxin 2 (FDX2).	Iron	185-187	ferredoxin 2	Homo sapiens	323-335
32776106-2	2020	In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the secondary carrier, ISCA1, as the direct donors of Fe-S clusters to mitochondrial NFU1, which appears to dimerize and reductively mediate formation of a bridging [4Fe-4S] cluster, aided by ferredoxin 2 (FDX2).	Iron	185-187	ferredoxin 2	Homo sapiens	337-341
33304466-8	2020	Moreover, recent studies in the yeast Saccharomyces cerevisiae have also revealed that multiple transcription factors including Yap5 and Msn2/Msn4 contribute to the expression of CCC1 in high-iron conditions.	Iron	192-196	Yap5p	Saccharomyces cerevisiae S288C	128-132
33304466-8	2020	Moreover, recent studies in the yeast Saccharomyces cerevisiae have also revealed that multiple transcription factors including Yap5 and Msn2/Msn4 contribute to the expression of CCC1 in high-iron conditions.	Iron	192-196	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	137-141
33228260-1	2020	Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase.	Iron	128-132	heme oxygenase 1	Homo sapiens	0-16
33228260-1	2020	Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase.	Iron	128-132	heme oxygenase 1	Homo sapiens	18-22
32791852-7	2021	NRF2 was recently identified as the molecular sensor of iron-induced oxidative stress and is responsible for BMP6 expression by liver sinusoidal endothelial cells, which in turn activates hepcidin synthesis by hepatocytes to restore systemic iron levels.	Iron	242-246	hepcidin antimicrobial peptide	Homo sapiens	188-196
32791852-9	2021	On the other hand, low iron/hypoxia stabilize renal HIF-2alpha via inactivation of iron-dependent PHD dioxygenases, causing an erythropoietic stimulus that represses hepcidin via an inhibitory effect of erythroferrone on bone morphogenetic proteins.	Iron	23-27	endothelial PAS domain protein 1	Homo sapiens	52-62
32791852-9	2021	On the other hand, low iron/hypoxia stabilize renal HIF-2alpha via inactivation of iron-dependent PHD dioxygenases, causing an erythropoietic stimulus that represses hepcidin via an inhibitory effect of erythroferrone on bone morphogenetic proteins.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	166-174
32791852-9	2021	On the other hand, low iron/hypoxia stabilize renal HIF-2alpha via inactivation of iron-dependent PHD dioxygenases, causing an erythropoietic stimulus that represses hepcidin via an inhibitory effect of erythroferrone on bone morphogenetic proteins.	Iron	83-87	endothelial PAS domain protein 1	Homo sapiens	52-62
32791852-9	2021	On the other hand, low iron/hypoxia stabilize renal HIF-2alpha via inactivation of iron-dependent PHD dioxygenases, causing an erythropoietic stimulus that represses hepcidin via an inhibitory effect of erythroferrone on bone morphogenetic proteins.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	166-174
32791852-10	2021	Intestinal HIF-2alpha is also stabilized, increasing the expression of genes involved in dietary iron absorption.	Iron	97-101	endothelial PAS domain protein 1	Homo sapiens	11-21
32747156-1	2020	BACKGROUND: Genetic defects in the NFU1, an iron-sulfur cluster scaffold protein coding gene, which is vital in the final stage of assembly for iron sulfur proteins, have been defined as multiple mitochondrial dysfunctions syndrome I.	Iron	44-48	NFU1 iron-sulfur cluster scaffold	Homo sapiens	35-39
32995951-0	2020	Iron Overload-Induced Osteocyte Apoptosis Stimulates Osteoclast Differentiation Through Increasing Osteocytic RANKL Production In Vitro.	Iron	0-4	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	110-115
32995951-9	2020	Excessive iron exposure significantly promoted the gene expression and protein secretion of the RANKL in MLO-Y4 cells.	Iron	10-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	96-101
32995951-10	2020	Addition of RANKL-blocking antibody completely abolished the increase of osteoclast formation and bone resorption capacity induced by the CM from osteocytes exposed to excessive iron.	Iron	178-182	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	12-17
32995951-12	2020	The results showed osteocyte apoptosis induced by iron overload was reduced by QVD and accompanied by the decrease of soluble RANKL (sRANKL) in supernatant.	Iron	50-54	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	126-131
32995951-14	2020	These results indicated that iron overload-induced osteocyte apoptosis is required to regulate osteoclast differentiation by increasing osteocytic RANKL production.	Iron	29-33	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	147-152
31688330-2	2020	The intubated, ventilated patient"s inspired and expired fractions of O2 and CO2 (FiO2, FeO2, FiCO2 and FeCO2) are monitored in the operating room and can be used to calculate RER.	Iron	88-92	complement C2	Homo sapiens	77-80
33195633-8	2020	Macrophage iron sequestration in response to infection and inflammation is caused by inhibition of iron export via hepcidin-dependent and independent mechanisms.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	115-123
33195633-8	2020	Macrophage iron sequestration in response to infection and inflammation is caused by inhibition of iron export via hepcidin-dependent and independent mechanisms.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	115-123
33195633-9	2020	The hepatic mRNA levels of the iron-regulating hormone hepcidin were increased in only one control elephant suffering from chronic inflammation without mycobacterial infection.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	55-63
33195633-12	2020	This suggests that the hepcidin/ferroportin regulatory system aims to counteract iron restriction in splenic macrophages in M. tuberculosis infected elephants to provide iron for erythropoiesis and to limit iron availability for a pathogen that predominantly proliferates in macrophages.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	23-31
33195633-12	2020	This suggests that the hepcidin/ferroportin regulatory system aims to counteract iron restriction in splenic macrophages in M. tuberculosis infected elephants to provide iron for erythropoiesis and to limit iron availability for a pathogen that predominantly proliferates in macrophages.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	23-31
33195633-12	2020	This suggests that the hepcidin/ferroportin regulatory system aims to counteract iron restriction in splenic macrophages in M. tuberculosis infected elephants to provide iron for erythropoiesis and to limit iron availability for a pathogen that predominantly proliferates in macrophages.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	23-31
33143055-1	2020	We evaluated the impact of metal saturation of lactoferrin (with iron and manganese) on population numbers of pathogenic species relevant for neonatal sepsis that commonly originates from the gut due to bacterial translocation.	Iron	65-69	lactotransferrin	Rattus norvegicus	47-58
33145420-7	2020	Our results lead to a new hypothesis that human iron transport is regulated as the paired transfer of iron from ferroportin to Cp to transferrin, and the tyrosine residue in Cp acts as a gate to avoid reactive oxygen species (ROS) formation when Fe2+ delivery is dysregulated.	Iron	48-52	ceruloplasmin	Homo sapiens	127-129
33145420-7	2020	Our results lead to a new hypothesis that human iron transport is regulated as the paired transfer of iron from ferroportin to Cp to transferrin, and the tyrosine residue in Cp acts as a gate to avoid reactive oxygen species (ROS) formation when Fe2+ delivery is dysregulated.	Iron	48-52	ceruloplasmin	Homo sapiens	174-176
33145420-7	2020	Our results lead to a new hypothesis that human iron transport is regulated as the paired transfer of iron from ferroportin to Cp to transferrin, and the tyrosine residue in Cp acts as a gate to avoid reactive oxygen species (ROS) formation when Fe2+ delivery is dysregulated.	Iron	102-106	ceruloplasmin	Homo sapiens	127-129
33193643-8	2020	Despite frequent transfusions the patients do not show any signs of iron overload and hepcidin, a major regulator of iron uptake, is undetectable in their serum.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	86-94
33193643-10	2020	Conclusion: The lack of iron overload despite a reduced level of hepcidin in two transfusion-dependent PKD patients suggests the existence of a hepcidin-independent mechanism of iron regulation preventing iron overloading.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	144-152
33193643-10	2020	Conclusion: The lack of iron overload despite a reduced level of hepcidin in two transfusion-dependent PKD patients suggests the existence of a hepcidin-independent mechanism of iron regulation preventing iron overloading.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	144-152
33204474-0	2020	Shell biomass material supported nano-zero valent iron to remove Pb2+ and Cd2+ in water.	Iron	50-54	CD2 molecule	Homo sapiens	74-77
33204330-0	2020	YTHDF1-enhanced iron metabolism depends on TFRC m6A methylation.	Iron	16-20	YTH N6-methyladenosine RNA binding protein 1	Homo sapiens	0-6
33204330-9	2020	Results: YTHDF1 was found to be closely associated with ferritin levels and intratumoral iron concentrations in HPSCC patients at Sir Run Run Shaw Hospital.	Iron	89-93	YTH N6-methyladenosine RNA binding protein 1	Homo sapiens	9-15
33204330-10	2020	YTHDF1 induced-HPSCC tumorigenesis depends on iron metabolism in vivo in vitro.	Iron	46-50	YTH N6-methyladenosine RNA binding protein 1	Homo sapiens	0-6
33204330-12	2020	Gain-of-function and loss-of-function analyses validated the finding showing that TFRC is a crucial target gene for YTHDF1-mediated increases in iron metabolism.	Iron	145-149	YTH N6-methyladenosine RNA binding protein 1	Homo sapiens	116-122
33063192-5	2021	Iron homeostasis is controlled by the hepcidin-ferroportin axis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	38-46
33063192-6	2021	Hepcidin is a central regulator of iron metabolism and can also serve as a marker of systemic inflammation.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
33063192-9	2021	Conversely, hepcidin synthesis is suppressed during conditions requiring increased iron intake for enhanced erythropoiesis, such as iron deficiency anemia or hypoxia.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	12-20
33063192-11	2021	Production of hepcidin is influenced by the status of total body iron stores, systemic inflammatory activity and erythropoietic activity.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	14-22
33063192-16	2021	Contrarily, low levels of hepcidin indicate that oral iron therapy should be successful.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	26-34
33063192-17	2021	An understanding of hepcidin can help in understanding the body"s reaction to iron depletion during the inflammatory process.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	20-28
33177988-2	2020	Hepcidin could reduce iron in the central and peripheral nervous systems.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
33177988-3	2020	Here, we hypothesized that hepcidin could further decrease alpha-syn accumulation via reducing iron.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	27-35
33177988-3	2020	Here, we hypothesized that hepcidin could further decrease alpha-syn accumulation via reducing iron.	Iron	95-99	synuclein alpha	Homo sapiens	59-68
33081324-9	2020	Interestingly, this iron depletion-triggered signaling is enabled by p73, in the absence of p53, or in the presence of a p53 mutant form.	Iron	20-24	transformation related protein 73	Mus musculus	69-72
33081324-9	2020	Interestingly, this iron depletion-triggered signaling is enabled by p73, in the absence of p53, or in the presence of a p53 mutant form.	Iron	20-24	transformation related protein 53, pseudogene	Mus musculus	92-95
33081324-9	2020	Interestingly, this iron depletion-triggered signaling is enabled by p73, in the absence of p53, or in the presence of a p53 mutant form.	Iron	20-24	transformation related protein 53, pseudogene	Mus musculus	121-124
33081324-10	2020	In conclusion, we propose a mechanism by which the increased p53 family transcriptional activity and protein stability could explain the potential benefits of iron chelation therapy in terms of improving OS and delaying leukemic transformation.	Iron	159-163	transformation related protein 53, pseudogene	Mus musculus	61-64
32821928-4	2020	Mitochondria were purified either with discontinuous Percoll gradient or with anti-TOM22-conjugated iron microbeads.	Iron	100-104	translocase of outer mitochondrial membrane 22	Mus musculus	83-88
33029690-4	2021	The present study evaluates the serum hepcidin levels, as the main regulator of iron metabolism, and its relationship with RLS in chronic HD patients.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	38-46
32830958-0	2020	A novel method for assessing SO2 poisoning effect and thermal regeneration possibility of MOx-WO3/TiO2 (M= Fe, Mn, Cu, V) catalysts for NH3-SCR.	Iron	107-109	monooxygenase DBH like 1	Homo sapiens	90-93
33023155-2	2020	In patients suffering from Parkinson"s disease (PD), PINK1-PRKN mutations via deficient mitophagy trigger iron accumulation and reduce lifespan.	Iron	106-110	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	59-63
33023155-8	2020	The impact of PINK1 mutations in mouse and patient cells was pronounced only after iron overload, causing hyperreactive expression of ribosomal surveillance factor Abce1 and of ferritin, despite ferritin translation being repressed by IRP1.	Iron	83-87	PTEN induced putative kinase 1	Mus musculus	14-19
32678434-0	2020	The effect of iron dosing schedules on plasma hepcidin and iron absorption in Kenyan infants.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	46-54
32678434-1	2020	BACKGROUND: In adults, oral iron doses increase plasma hepcidin (PHep) for 24 h, but not for 48 h, and there is a circadian increase in PHep over the day.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	55-63
32480040-12	2020	Confocal microscopy co-localization studies and proximity ligation assays both demonstrated decreased interaction of ADI1 with PCBP1 and PCBP2 under conditions of iron depletion using DFO.	Iron	163-167	acireductone dioxygenase 1	Homo sapiens	117-121
32485269-0	2020	Hypomorphic CAMKK2 in EA.hy926 endothelial cells causes abnormal transferrin trafficking, iron homeostasis and glucose metabolism.	Iron	90-94	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	12-18
32485269-4	2020	The abnormal TF trafficking in CAMKK2 hypomorphic cells correlated with a reduction in intracellular iron content and defective glucose metabolism including glycolysis and mitochondrial respiration.	Iron	101-105	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	31-37
32485269-6	2020	These findings have identified a novel mechanistic link between abnormal calcium signaling, iron dyshomeostasis and metabolic dysfunction involving CAMKK2.	Iron	92-96	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	148-154
32341450-0	2020	Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.	Iron	64-68	synuclein alpha	Homo sapiens	0-15
32634551-1	2020	Anemia is an inherent complication of older individuals with end-stage renal disease (ESRD) that is associated with inflammation which in turn is an important factor in the activation of hepcidin that contributes to the decrease in serum iron.	Iron	238-242	hepcidin antimicrobial peptide	Homo sapiens	187-195
32741217-3	2020	Also, changes in other iron-related proteins including transferrin, ferritin, and hepcidin were observed both in the serum as well as in their mRNA expression.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	82-90
32814342-0	2020	Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	13-21
32814342-1	2020	The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	82-90
32814342-1	2020	The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	82-90
32814342-2	2020	Hepcidin regulates iron absorption and recycling by inducing ferroportin internalization and degradation1.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	0-8
32814342-6	2020	Hepcidin binds ferroportin in an outward-open conformation and completely occludes the iron efflux pathway to inhibit transport.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
32814342-8	2020	We further show that hepcidin binding to ferroportin is coupled to iron binding, with an 80-fold increase in hepcidin affinity in the presence of iron.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	21-29
32814342-8	2020	We further show that hepcidin binding to ferroportin is coupled to iron binding, with an 80-fold increase in hepcidin affinity in the presence of iron.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	109-117
32814342-8	2020	We further show that hepcidin binding to ferroportin is coupled to iron binding, with an 80-fold increase in hepcidin affinity in the presence of iron.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	21-29
32814342-8	2020	We further show that hepcidin binding to ferroportin is coupled to iron binding, with an 80-fold increase in hepcidin affinity in the presence of iron.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	109-117
32814342-9	2020	These results suggest a model for hepcidin regulation of ferroportin, where only iron loaded ferroportin molecules are targeted for degradation.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	34-42
32814342-10	2020	More broadly, our structural and functional insights are likely to enable more targeted manipulation of the hepcidin-ferroportin axis in disorders of iron homeostasis.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	108-116
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	solute carrier family 7 member 11	Homo sapiens	243-250
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	adhesion G protein-coupled receptor G3	Homo sapiens	334-340
32970808-0	2020	The role of hepcidin in fetal iron homeostasis.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	12-20
32968051-0	2020	Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron.	Iron	121-125	heme oxygenase 1	Homo sapiens	0-16
32972031-5	2020	These pathways are associated with dysregulation of iron homeostasis, including the downregulation of the hepatic hormone hepcidin.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	122-130
32972031-6	2020	Increased haemolysis and low hepcidin levels potentially increase plasma, tissue and intracellular iron levels.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	29-37
32809827-0	2020	A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species.	Iron	80-84	glutathione peroxidase 4	Homo sapiens	34-38
32809827-5	2020	Moreover, QD394 causes an iron- and ROS-dependent, GPX4 mediated cell death, suggesting ferroptosis as a major mechanism.	Iron	26-30	glutathione peroxidase 4	Homo sapiens	51-55
33015091-3	2020	We previously reported that in female NZBWF1 mice, a commonly used mouse model of SLE with a female sex bias, increased urinary transferrin excretion and renal iron accumulation occur around the onset of albuminuria.	Iron	160-164	WD repeat and FYVE domain containing 3	Mus musculus	38-44
32614379-9	2020	Net transfer of iron to the neonate was higher in women with lower total body iron (standardized beta = -0.48, P < 0.01) and lower maternal hepcidin (standardized beta = -0.66, P < 0.01).	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	140-148
32614379-10	2020	In women carrying multiple fetuses, neonatal hepcidin explained a significant amount of observed variance in net placental transfer of absorbed iron (R = 0.95, P = 0.03).	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	45-53
32614379-13	2020	Maternal hepcidin was inversely associated with maternal RBC iron utilization, whereas neonatal hepcidin explained variance in net transfer of iron to the neonatal compartment.These trials were registered at clinicaltrials.gov as NCT01019096 and NCT01582802.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	96-104
32607613-7	2020	Selective iron chelation within the physiological range of pH values and uptake by LAT1 were confirmed.	Iron	10-14	solute carrier family 7 member 5	Homo sapiens	83-87
32565401-3	2020	Cth2 is a tandem zinc-finger (TZF)-containing protein that co-transcriptionally binds to adenine/uracil-rich elements (ARE) present in the 3"-untranslated region of iron-related mRNAs to promote their turnover.	Iron	165-169	Tis11p	Saccharomyces cerevisiae S288C	0-4
32565401-10	2020	The importance of these interactions is highlighted by the specific growth defect in iron-deficient conditions displayed by cells lacking Dhh1, Pop2, Ccr4 or Xrn1.	Iron	85-89	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	144-148
32585319-1	2020	The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	95-103
32585319-2	2020	Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron for red blood cell production, while limiting the toxic effects of excess iron.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
32585319-2	2020	Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron for red blood cell production, while limiting the toxic effects of excess iron.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
32585319-2	2020	Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron for red blood cell production, while limiting the toxic effects of excess iron.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
32585319-2	2020	Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron for red blood cell production, while limiting the toxic effects of excess iron.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
32585319-2	2020	Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron for red blood cell production, while limiting the toxic effects of excess iron.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
32585319-4	2020	Most major signals that influence hepcidin production, including iron, erythropoietic drive, and inflammation, intersect with the BMP-SMAD pathway to regulate hepcidin transcription.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	34-42
32409771-0	2020	Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.	Iron	76-80	synuclein alpha	Homo sapiens	12-27
32667087-7	2020	In iron-deficient mice, erythropoietin levels were higher but erythropoietin-regulated genes were generally downregulated relative to iron-replete mice, suggesting erythropoietin resistance.	Iron	3-7	erythropoietin	Mus musculus	24-38
32667087-7	2020	In iron-deficient mice, erythropoietin levels were higher but erythropoietin-regulated genes were generally downregulated relative to iron-replete mice, suggesting erythropoietin resistance.	Iron	3-7	erythropoietin	Mus musculus	62-76
32667087-7	2020	In iron-deficient mice, erythropoietin levels were higher but erythropoietin-regulated genes were generally downregulated relative to iron-replete mice, suggesting erythropoietin resistance.	Iron	3-7	erythropoietin	Mus musculus	62-76
32574378-0	2020	H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity.	Iron	32-36	synuclein alpha	Homo sapiens	65-80
32574378-2	2020	Previous studies have suggested that iron accumulation contributes to the Parkinson"s disease pathology through reactive oxygen species production and accelerated alpha-synuclein aggregation.	Iron	37-41	synuclein alpha	Homo sapiens	163-178
32574378-3	2020	This study examines the effects of commonly occurring H63D variant of the homeostatic iron regulatory (HFE) gene on alpha-synuclein pathology in cell culture and animal models.	Iron	86-90	synuclein alpha	Homo sapiens	116-131
32621820-0	2020	SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes.	Iron	31-35	solute carrier family 46 member 1	Homo sapiens	0-7
32621820-1	2020	BACKGROUND: Iron is finely regulated due to its vital roles in organisms and the peroxidase reactivity if excess.	Iron	12-16	peroxidase	None	81-91
32621820-2	2020	Solute Carrier Family 46 Member 1 (SLC46A1), also named PCFT/HCP1, is the main importer of heme-iron in the intestine, but has a high abundance in the liver.	Iron	96-100	solute carrier family 46 member 1	Homo sapiens	0-33
32621820-2	2020	Solute Carrier Family 46 Member 1 (SLC46A1), also named PCFT/HCP1, is the main importer of heme-iron in the intestine, but has a high abundance in the liver.	Iron	96-100	solute carrier family 46 member 1	Homo sapiens	35-42
32621820-2	2020	Solute Carrier Family 46 Member 1 (SLC46A1), also named PCFT/HCP1, is the main importer of heme-iron in the intestine, but has a high abundance in the liver.	Iron	96-100	solute carrier family 46 member 1	Homo sapiens	56-65
32621820-3	2020	Since the liver has a central role in iron homeostasis, whether SLC46A1 regulates hepatic iron metabolism is of interest to be identified.	Iron	90-94	solute carrier family 46 member 1	Homo sapiens	64-71
32621820-6	2020	Furthermore, effects of iron on SLC46A1 expression were investigated both in vitro and in vivo.	Iron	24-28	solute carrier family 46 member 1	Homo sapiens	32-39
32621820-7	2020	RESULTS: The hepatocyte-specific inhibition of SLC46A1 decreases iron content in the liver and increases iron content in serum.	Iron	65-69	solute carrier family 46 member 1	Homo sapiens	47-54
32621820-7	2020	RESULTS: The hepatocyte-specific inhibition of SLC46A1 decreases iron content in the liver and increases iron content in serum.	Iron	105-109	solute carrier family 46 member 1	Homo sapiens	47-54
32621820-10	2020	In hepatocytes, SLC46A1 is capable of importing hemin, increasing intracellular iron content.	Iron	80-84	solute carrier family 46 member 1	Homo sapiens	16-23
32621820-13	2020	In addition, SLC46A1 itself shows to be iron-responsive both in vivo and in vitro, making it available for regulating iron metabolism.	Iron	40-44	solute carrier family 46 member 1	Homo sapiens	13-20
32621820-13	2020	In addition, SLC46A1 itself shows to be iron-responsive both in vivo and in vitro, making it available for regulating iron metabolism.	Iron	118-122	solute carrier family 46 member 1	Homo sapiens	13-20
32621820-14	2020	CONCLUSION: The results elucidate that SLC46A1 regulates iron metabolism in the liver through a folate-independent manner of importing heme.	Iron	57-61	solute carrier family 46 member 1	Homo sapiens	39-46
32621820-15	2020	The iron-responsive characters of SLC46A1 give us a new clue to link heme or iron overload with folate deficiency diseases.	Iron	4-8	solute carrier family 46 member 1	Homo sapiens	34-41
32621820-15	2020	The iron-responsive characters of SLC46A1 give us a new clue to link heme or iron overload with folate deficiency diseases.	Iron	77-81	solute carrier family 46 member 1	Homo sapiens	34-41
31743298-1	2020	BACKGROUND: Hepcidin is a liver-derived master regulator of iron metabolism through its molecular target ferroportin, the only known mammalian iron exporter.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	12-20
31743298-1	2020	BACKGROUND: Hepcidin is a liver-derived master regulator of iron metabolism through its molecular target ferroportin, the only known mammalian iron exporter.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	12-20
32847014-1	2020	Lactoferrin (Lf), an iron-binding multifunctional glycoprotein belonging to the transferrin family, is present in most biological secretions and reaches particularly high concentrations in colostrum and breast milk.	Iron	21-25	lactotransferrin	Bos taurus	0-11
33564406-4	2021	Iron has two opposite effects on erythropoiesis: it activates erythroid differentiation directly by supplying iron but inhibits it indirectly by stimulating hepcidin and enhancing oxidative stress.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	157-165
33564406-5	2021	Hepcidin plays an essential role not only in iron homeostasis and the anemia of chronic kidney disease, but also in its complications such as atherosclerosis and infection.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
32973714-8	2020	Investigating the possibility that 2,2"-bipyridyl in the ttgB mutant mediates iron accumulation in cells (which would cause the upregulation of genes involved in oxidative stress via the Fenton reaction), we measured the expression of genes coding for proteins involved in intracellular iron storage and the response to oxidative stress.	Iron	78-82	multidrug efflux RND transporter permease subunit TtgB	Pseudomonas putida KT2440	57-61
32973714-8	2020	Investigating the possibility that 2,2"-bipyridyl in the ttgB mutant mediates iron accumulation in cells (which would cause the upregulation of genes involved in oxidative stress via the Fenton reaction), we measured the expression of genes coding for proteins involved in intracellular iron storage and the response to oxidative stress.	Iron	287-291	multidrug efflux RND transporter permease subunit TtgB	Pseudomonas putida KT2440	57-61
32973714-11	2020	In this context, we found that the addition of copper restores the growth of the ttgB mutant and the production of pyoverdine, suggesting a relationship between copper availability and iron acquisition.	Iron	185-189	multidrug efflux RND transporter permease subunit TtgB	Pseudomonas putida KT2440	81-85
32913554-4	2020	The effects of a recombinant adeno-associated virus targeting hepcidin (AAV-hepcidin) for hippocampal iron content and cognitive function were investigated in a T2DM rat model induced by streptozotocin and a high-fat diet.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	62-70
32913554-4	2020	The effects of a recombinant adeno-associated virus targeting hepcidin (AAV-hepcidin) for hippocampal iron content and cognitive function were investigated in a T2DM rat model induced by streptozotocin and a high-fat diet.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	76-84
32824233-1	2020	Juvenile hemochromatosis (JH), type 2A hemochromatosis, is a rare autosomal recessive disorder of systemic iron overload due to homozygous mutations of HJV (HFE2), which encodes hemojuvelin, an essential regulator of the hepcidin expression, causing liver fibrosis, diabetes, and heart failure before 30 years of age, often with fatal outcomes.	Iron	107-111	hemojuvelin BMP co-receptor	Homo sapiens	152-155
32759740-6	2020	Treatment of stable clones of SEC23B-silenced erythroleukemia K562 cells with the iron-containing porphyrin hemin plus GDF11 increased expression of pSMAD2 and reduced nuclear localization of the transcription factor GATA1, with subsequent reduced gene expression of erythroid differentiation markers.	Iron	82-86	SEC23 homolog B, COPII coat complex component	Homo sapiens	30-36
32759740-8	2020	Our data also demonstrate the effect of RAP-011 treatment in reducing the expression of erythroferrone in vitro, thus suggesting a possible beneficial role of the use of sotatercept in the management of iron overload in patients with CDA II.	Iron	203-207	LDL receptor related protein associated protein 1	Homo sapiens	40-43
32251709-1	2020	BACKGROUND: Expression of hepcidin, a hormone produced by hepatocytes which negatively regulates the circulating iron levels, is known to be positively regulated by BMP6, a member of transforming growth factor (TGF)-beta family.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	26-34
32251709-14	2020	CONCLUSIONS: The present study reveals non-iron-regulated Bmp6 expression in endothelial cells.	Iron	43-47	bone morphogenetic protein 6	Mus musculus	58-62
31778583-1	2020	Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin.	Iron	118-122	bone morphogenetic protein 6	Mus musculus	37-41
31778583-6	2020	Notably, dietary iron loading still induced liver SMAD5 phosphorylation and hepcidin in double Bmp6/endothelial Bmp2 KO mice, although no other BMP ligand mRNAs were increased in the livers of double KO mice, and only Bmp6 and Bmp2 mRNA were induced by dietary iron loading in wildtype mice.	Iron	17-21	bone morphogenetic protein 6	Mus musculus	95-99
31778583-6	2020	Notably, dietary iron loading still induced liver SMAD5 phosphorylation and hepcidin in double Bmp6/endothelial Bmp2 KO mice, although no other BMP ligand mRNAs were increased in the livers of double KO mice, and only Bmp6 and Bmp2 mRNA were induced by dietary iron loading in wildtype mice.	Iron	17-21	bone morphogenetic protein 6	Mus musculus	218-222
31778583-10	2020	CONCLUSION: These data suggest that BMP2 and BMP6 work collaboratively to regulate hepcidin expression, that BMP2- and BMP6-independent SMAD1/5/8 signaling contributes a non-redundant role to hepcidin regulation by iron, and that HFE regulates hepcidin at least in part through a BMP2-independent, but SMAD1/5/8-dependent, mechanism.	Iron	215-219	SMAD family member 1	Mus musculus	136-143
32450003-11	2020	Evasion of mutant ferroportin from hepcidin-mediated regulation could result in uncontrolled iron absorption and iron overload despite reduced transport function.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	35-43
32450003-11	2020	Evasion of mutant ferroportin from hepcidin-mediated regulation could result in uncontrolled iron absorption and iron overload despite reduced transport function.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	35-43
32935805-1	2020	BACKGROUND: Hepcidin is an important regulator of iron homeostasis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	12-20
32935805-10	2020	CONCLUSION: Hepcidin, a well-known hormone regulator of iron metabolism, may play an important role in the pathogenesis of metabolic syndrome in patients with CKD, and further studies might delineate in-depth its potential as a promising early marker in these patients.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	12-20
32450084-2	2020	Iron obtained from daily diet is passed through the intestinal enterocyte apical membrane via divalent metal transporter 1 (DMT1), which is either stored as ferritin or moved into the plasma by hepcidin-ferroportin (Fpn) as an exporter.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	94-122
32450084-2	2020	Iron obtained from daily diet is passed through the intestinal enterocyte apical membrane via divalent metal transporter 1 (DMT1), which is either stored as ferritin or moved into the plasma by hepcidin-ferroportin (Fpn) as an exporter.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	124-128
2605266-6	1989	Apolactoferrin purified in this manner bound iron and displayed a UV/VIS absorption spectrum indistinguishable from that of human lactoferrin.	Iron	45-49	lactotransferrin	Bos taurus	3-14
2559964-4	1989	We propose that these lipophilic compounds bind to 5-lipoxygenase and reduce the iron in the active site, thus inactivating the enzyme.	Iron	81-85	arachidonate 5-lipoxygenase	Rattus norvegicus	51-65
32970625-1	2020	The application of activated carbon fiber supported nanoscale zero-valent iron (ACF-nZVI) in the continuous removal of Cr(VI) and methyl orange (MO) from aqueous solution was studied in depth.	Iron	74-78	ACF	Homo sapiens	80-83
2512907-10	1989	They also indicate that stimulation of 5-lipoxygenase activity can contribute to increase lipid peroxidation in iron and nucleotide-promoted reactions.	Iron	112-116	arachidonate 5-lipoxygenase	Rattus norvegicus	39-53
32874605-3	2020	It was found that sch can be successfully carried by FLG in sch-FLG composite, mainly via the chemical bond of Fe-O-C on the surface of sch-FLG.	Iron	111-114	filaggrin	Homo sapiens	53-56
32874605-3	2020	It was found that sch can be successfully carried by FLG in sch-FLG composite, mainly via the chemical bond of Fe-O-C on the surface of sch-FLG.	Iron	111-114	filaggrin	Homo sapiens	64-67
32874605-3	2020	It was found that sch can be successfully carried by FLG in sch-FLG composite, mainly via the chemical bond of Fe-O-C on the surface of sch-FLG.	Iron	111-114	filaggrin	Homo sapiens	64-67
2510407-6	1989	This mechanism of non-enzymic activation of CCl4 by protohaem mimics that catalyzed by cytochrome P-450 in that it requires a free, reduced haem iron and electron donation and it is largely prevented by carbon monoxide.	Iron	145-149	C-C motif chemokine ligand 4	Homo sapiens	44-48
33659355-2	2020	Our recent publication demonstrates the production of ftn-PAK4, which is a ferritin-containing crystal that can mineralize iron and become magnetic when isolated.	Iron	123-127	p21 (RAC1) activated kinase 4	Homo sapiens	58-62
32765573-0	2020	Corrigendum: The Conservation of VIT1-Dependent Iron Distribution in Seeds.	Iron	48-52	F-box protein 11	Homo sapiens	33-37
2777751-1	1989	Chicken ovotransferrin, an iron binding protein, has two metal binding sites (amino (N) and carboxy (C) terminal sites).	Iron	27-31	transferrin (ovotransferrin)	Gallus gallus	8-22
32409586-2	2020	It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III).	Iron	110-114	STEAP2 metalloreductase	Homo sapiens	48-54
32409586-7	2020	Enzymatic assays in human cells revealed that STEAP1 promotes iron(III) reduction when fused to the intracellular NADPH-binding domain of its family member STEAP4, suggesting that STEAP1 functions as a ferric reductase in STEAP heterotrimers.	Iron	62-66	STEAP family member 1	Homo sapiens	46-52
32409586-7	2020	Enzymatic assays in human cells revealed that STEAP1 promotes iron(III) reduction when fused to the intracellular NADPH-binding domain of its family member STEAP4, suggesting that STEAP1 functions as a ferric reductase in STEAP heterotrimers.	Iron	62-66	STEAP family member 1	Homo sapiens	180-186
32409586-7	2020	Enzymatic assays in human cells revealed that STEAP1 promotes iron(III) reduction when fused to the intracellular NADPH-binding domain of its family member STEAP4, suggesting that STEAP1 functions as a ferric reductase in STEAP heterotrimers.	Iron	62-66	STEAP family member 1	Homo sapiens	46-51
2660938-2	1989	At the molecular level, the main features are: the increased capacity of cells to bind toxic, inorganic iron to a specific storage protein, apoferritin, which becomes visible due to its iron-containing, electron-opaque core; since iron itself is involved in the de-repression of apoferritin synthesis, the number of assembled ferritin molecules depends on the amount of unbound iron present in the cell; there is a maximal, cell line-specific concentration of cytosolic ferritin; ferritin particles have a variable iron content, with richer molecules having a tendency to form clusters.	Iron	186-190	ferritin heavy chain 1	Homo sapiens	140-151
32414791-5	2020	Glrx3/hGMPs interact through conserved residues which bridge iron/sulphur clusters and glutathione.	Iron	61-65	glutaredoxin 3	Homo sapiens	0-5
2660938-2	1989	At the molecular level, the main features are: the increased capacity of cells to bind toxic, inorganic iron to a specific storage protein, apoferritin, which becomes visible due to its iron-containing, electron-opaque core; since iron itself is involved in the de-repression of apoferritin synthesis, the number of assembled ferritin molecules depends on the amount of unbound iron present in the cell; there is a maximal, cell line-specific concentration of cytosolic ferritin; ferritin particles have a variable iron content, with richer molecules having a tendency to form clusters.	Iron	186-190	ferritin heavy chain 1	Homo sapiens	140-151
2660938-2	1989	At the molecular level, the main features are: the increased capacity of cells to bind toxic, inorganic iron to a specific storage protein, apoferritin, which becomes visible due to its iron-containing, electron-opaque core; since iron itself is involved in the de-repression of apoferritin synthesis, the number of assembled ferritin molecules depends on the amount of unbound iron present in the cell; there is a maximal, cell line-specific concentration of cytosolic ferritin; ferritin particles have a variable iron content, with richer molecules having a tendency to form clusters.	Iron	186-190	ferritin heavy chain 1	Homo sapiens	140-151
32129080-3	2020	Based on the available information, we speculated that CPX could increase iron content in the tissues and then induce oxidative stress.	Iron	74-78	coproporphyrinogen oxidase	Mus musculus	55-58
32129080-5	2020	RESULTS: We demonstrated that CPX could induce a significant increase in iron contents and ferritin expression in the liver and spleen, notably inhibit erythropoiesis and Hb synthesis and lead to a reduction in iron usage.	Iron	73-77	coproporphyrinogen oxidase	Mus musculus	30-33
2660938-2	1989	At the molecular level, the main features are: the increased capacity of cells to bind toxic, inorganic iron to a specific storage protein, apoferritin, which becomes visible due to its iron-containing, electron-opaque core; since iron itself is involved in the de-repression of apoferritin synthesis, the number of assembled ferritin molecules depends on the amount of unbound iron present in the cell; there is a maximal, cell line-specific concentration of cytosolic ferritin; ferritin particles have a variable iron content, with richer molecules having a tendency to form clusters.	Iron	186-190	ferritin heavy chain 1	Homo sapiens	140-151
32129080-5	2020	RESULTS: We demonstrated that CPX could induce a significant increase in iron contents and ferritin expression in the liver and spleen, notably inhibit erythropoiesis and Hb synthesis and lead to a reduction in iron usage.	Iron	211-215	coproporphyrinogen oxidase	Mus musculus	30-33
32129080-6	2020	The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2.	Iron	77-81	coproporphyrinogen oxidase	Mus musculus	65-68
2631873-0	1989	Modulation of macrophage iron metabolism by tumour necrosis factor and interleukin 1.	Iron	25-29	interleukin 1 alpha	Homo sapiens	71-84
31994303-1	2020	BACKGROUND: It is known that daily divided doses and high doses of iron increase hepcidin and reduce iron absorption.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	81-89
2918910-6	1989	It also correlates with a glass-like transition in the hydration shell of myoglobin and with the temperature-dependence of ligand-binding rates at the heme iron, as monitored by flash photolysis.	Iron	156-160	myoglobin	Homo sapiens	74-83
32975106-2	2020	The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity.	Iron	77-81	glutathione peroxidase 4	Homo sapiens	256-280
2744579-1	1989	Met-myoglobin is oxidized both by H2O2 and other hydroperoxides to a species with a higher iron valency state and the spectral characteristics of ferryl-myoglobin.	Iron	91-95	myoglobin	Homo sapiens	4-13
32337520-4	2020	The mitochondrial inner membrane protein Atm1p can transport glutathione-coordinated iron-sulfur clusters, which may connect the mitochondrial and cytosolic iron-sulfur cluster assembly systems.	Iron	85-89	ATP binding cassette subfamily B member 7	Homo sapiens	41-46
32555299-1	2020	Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
2792847-5	1989	Iron(II) complexes such as haemin from the breakdown of dietary haemoglobin and myoglobin also serve as growth factors for these bacteria and provide a rich source of haem-iron for intestinal uptake.	Iron	172-176	myoglobin	Homo sapiens	80-89
32048363-6	2020	RESULTS: A {AuNPs, Fe-MOF} nano-composite was prepared and found suitable for the LDI generation of Aum Fen clusters.	Iron	19-21	phosphoglycolate phosphatase	Homo sapiens	100-103
32048363-11	2020	A broad series of over 100 bimetallic Aum Fen clusters, some of them suggested to be gold cages doped with iron atoms (for m = 12 and higher), not only demonstrate a rich and complex chemistry, but also open wide possibilities of biomedical applications.	Iron	107-111	phosphoglycolate phosphatase	Homo sapiens	38-41
2806954-0	1989	The suppression of iron release from activated myoglobin by physiological electron donors and by desferrioxamine.	Iron	19-23	myoglobin	Homo sapiens	47-56
32542039-1	2020	FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism.	Iron	18-22	BRCA1 interacting helicase 1	Homo sapiens	0-5
32542039-1	2020	FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism.	Iron	18-22	BRCA1 interacting helicase 1	Homo sapiens	6-11
2806954-2	1989	In such systems hydroxyl radical formation has also been demonstrated by its ability to degrade deoxyribose subsequent to the release of iron from the porphyrin ring of the myoglobin.	Iron	137-141	myoglobin	Homo sapiens	173-182
32542039-1	2020	FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism.	Iron	31-34	BRCA1 interacting helicase 1	Homo sapiens	0-5
32542039-1	2020	FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism.	Iron	31-34	BRCA1 interacting helicase 1	Homo sapiens	6-11
2806954-4	1989	The results show that iron release from ferrimyoglobin activated by hydrogen peroxide is suppressed in the presence of membranes, apparently by the reduction of the ferryl myoglobin species, and lipid peroxidation occurs.	Iron	22-26	myoglobin	Homo sapiens	45-54
2806954-6	1989	The physiological antioxidant ascorbate not only suppresses the formation of the ferryl myoglobin species under the conditions described here, but also reduces the myoglobin iron to the iron II state.	Iron	174-178	myoglobin	Homo sapiens	164-173
18964710-4	1989	Reduced myoglobin binds one molecule of oxygen to the heme iron but no reports have been found that suggest that the oxidized form of myoglobin binds to, or contains a molecule of, oxygen.	Iron	59-63	myoglobin	Homo sapiens	8-17
32537798-1	2020	BACKGROUND: Hepcidin is a key regulator of iron homeostasis.	Iron	43-47	hepcidin antimicrobial peptide	Canis lupus familiaris	12-20
32460794-17	2020	CONCLUSION: Overall, this study established a novel mechanistic link between intracellular Ca2+ level, receptor-mediated TF trafficking, and iron homeostasis, all regulated by CAMKK2-CAMK4 signaling.	Iron	141-145	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	176-182
2906908-4	1988	Competition experiments further indicated that iron interacts specifically with CD2 on T lymphocytes.	Iron	47-51	CD2 molecule	Homo sapiens	80-83
3169034-0	1988	Transferrin iron interactions with cultured hepatocellular carcinoma cells (PLC/PRF/5).	Iron	12-16	heparan sulfate proteoglycan 2	Homo sapiens	76-79
32165281-6	2020	Converging evidence on both mechanism of LPO and GPx4 enzymology indicates that LPO is initiated by alkoxyl radicals produced by ferrous iron from the hydroperoxide derivatives of lipids (LOOH), traces of which are the unavoidable drawback of aerobic metabolism.	Iron	137-141	glutathione peroxidase 4	Homo sapiens	49-53
3373110-2	1988	Ceruloplasmin functions as a ferroxidase that oxidizes iron to the Fe3+ state, thereby preventing Fe2+-catalyzed lipid peroxidation and cellular damage.	Iron	55-59	ceruloplasmin	Homo sapiens	0-13
32393788-3	2020	The fasting-mimicking diet selectivity reverses vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin in KRAS-mutant cancer cells, consequently increasing reactive iron, oxygen species, and cell death; an effect further potentiated by chemotherapy.	Iron	175-179	heme oxygenase 1	Homo sapiens	83-99
2833117-2	1988	It has been suggested that lactoferrin, the major iron-binding protein in human milk, may participate in this high iron bioavailability from milk.	Iron	50-54	lactotransferrin	Bos taurus	27-38
32157726-7	2020	Our results highlight antioxidant and iron import pathways as determinants of HIV-1 latency and support their pharmacologic inhibition as tools to regulate PML stability and impair latency establishment.	Iron	38-42	PML nuclear body scaffold	Homo sapiens	156-159
2833117-2	1988	It has been suggested that lactoferrin, the major iron-binding protein in human milk, may participate in this high iron bioavailability from milk.	Iron	115-119	lactotransferrin	Bos taurus	27-38
2833117-9	1988	It was concluded that lactoferrin in milk may function in the process of iron absorption through interaction with a small intestinal receptor and that fucosylated glycans on the carbohydrate chain of lactoferrin are necessary for receptor recognition.	Iron	73-77	lactotransferrin	Bos taurus	22-33
32454791-1	2020	The liver is the organ for iron storage and regulation; it senses circulating iron concentrations in the body through the BMP-SMAD pathway and regulates the iron intake from food and erythrocyte recovery into the bloodstream by secreting hepcidin.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	238-246
32454791-2	2020	Under iron deficiency, hypoxia, and hemorrhage, the liver reduces the expression of hepcidin to ensure the erythropoiesis but increases the excretion of hepcidin during infection and inflammation to reduce the usage of iron by pathogens.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	84-92
32454791-2	2020	Under iron deficiency, hypoxia, and hemorrhage, the liver reduces the expression of hepcidin to ensure the erythropoiesis but increases the excretion of hepcidin during infection and inflammation to reduce the usage of iron by pathogens.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	153-161
32454791-4	2020	When some gene mutations affect the perception of iron and iron regulation ability in the liver, then they decrease the expression of hepcidin, causing hereditary diseases such as hereditary hemochromatosis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	134-142
32454791-4	2020	When some gene mutations affect the perception of iron and iron regulation ability in the liver, then they decrease the expression of hepcidin, causing hereditary diseases such as hereditary hemochromatosis.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	134-142
2825793-4	1987	Three different forms of complexed cytochrome c have been characterized by optical and EPR spectroscopies, in the pH range 6.5-8: an N form, close to the native structure, an A form, analogous to cytochrome c in acidic medium, and a novel B form in which the heme pocket is open but the iron remains low-spin.	Iron	287-291	cytochrome c, somatic	Equus caballus	35-47
32454791-5	2020	This review summarizes the source and utilization of iron in the body, the liver regulates systemic iron homeostasis by sensing the circulating iron concentration, and the expression of hepcidin regulated by various signaling pathways, thereby understanding the pathogenesis of iron-related diseases.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	186-194
32088260-2	2020	Hepcidin dysregulation causes different human disorders ranging from iron overload (e.g. hemochromatosis) to iron deficiency (e.g. anemia).	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	0-8
3036144-3	1987	The NO-ferrous cytochrome c" would be a mixture of NO complexes with six- and five-coordinate nitrosylheme, suggesting that the heme-iron to histidine bond in the ferrous cytochrome c" is more stable than that from chemoheterotrophic bacteria.	Iron	133-137	cytochrome c, somatic	Equus caballus	15-27
31377936-6	2020	In addition, compared to parenteral iron supplementation, greater serum IgA level, SOD, and GSH-Px activities, lower expressions of IL-1beta and TNF-alpha in the liver, and lower expressions of IL-6 and TNF-alpha in the spleen were found in oral iron piglets (P &lt; 0.05).	Iron	36-40	IGHA	Sus scrofa	72-75
3032307-0	1987	Iron deficiency and neutrophil function: different rates of correction of the depressions in oxidative burst and myeloperoxidase activity after iron treatment.	Iron	144-148	myeloperoxidase	Rattus norvegicus	113-128
3034243-3	1987	EPR and electronic spectral results for the ferric cytochrome c" suggest that the ground state of heme-iron(III) at neutral pH consists of a quantum mechanical admixture of an intermediate-spin and a high-spin state and that at pH 11.0 is in a high-spin state.	Iron	103-107	cytochrome c, somatic	Equus caballus	51-63
31664635-3	2020	In this article, the potential application of iron- and steelmaking slag has been reviewed, which included the slag utilization in construction as cement and sand, in water, soil, and gas treatment, as well as in value material recovery.	Iron	46-50	gastrin	Homo sapiens	184-187
3584611-3	1987	The human lactoferrin recovered from defatted human colostrum was 98% pure with 93% iron-binding capacity.	Iron	84-88	lactotransferrin	Bos taurus	10-21
3584611-5	1987	The best source to isolate bovine lactoferrin was raw skim milk yielding a protein 97% pure and with a 99% iron-binding capacity.	Iron	107-111	lactotransferrin	Bos taurus	34-45
31624364-11	2020	CONCLUSIONS: Ascertaining hemoglobin and hepcidin levels may improve the targeting of iron supplementation programs in resource-limited countries, though hepcidin"s high costs may limit its use.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	41-49
3584611-6	1987	Thus, immunoaffinity chromatography provides an effective one-pass isolation of highly pure human or bovine lactoferrin with reasonable recovery and iron-binding capacity.	Iron	149-153	lactotransferrin	Bos taurus	108-119
3604297-7	1987	Iron is of central importance among these active substances, since its presence in haemoglobin is essential for the transport of oxygen and carbon dioxide, makes it possible for myoglobin to function as an oxygen supply depot and guarantees the functioning of internal respiration in the respiratory chain and various key enzymes.	Iron	0-4	myoglobin	Homo sapiens	178-187
32112801-4	2020	This was associated with reduced ferritin induction by hemoglobin; expression of heme oxygenase-1, which catalyzes iron release from heme, was not altered.	Iron	115-119	heme oxygenase 1	Homo sapiens	81-97
3469917-0	1987	Effects of purified iron-saturated human lactoferrin on spleen morphology in mice infected with Friend virus complex.	Iron	20-24	lactotransferrin	Mus musculus	41-52
32296847-7	2020	In particular, iron overload-related mitochondrial ferritin and nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) proteins were increased in the hippocampus of ob/ob.	Iron	15-19	leptin	Mus musculus	185-187
32296847-7	2020	In particular, iron overload-related mitochondrial ferritin and nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) proteins were increased in the hippocampus of ob/ob.	Iron	15-19	leptin	Mus musculus	188-190
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	46-48	ceruloplasmin	Homo sapiens	54-67
32185675-1	2020	Hepcidin is the master regulator of systemic iron homeostasis and its dysregulation is observed in several chronic liver diseases.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
32185675-2	2020	Unlike the extracellular iron-sensing mechanisms, the intracellular iron-sensing mechanisms in the hepatocytes that lead to hepcidin induction and secretion are incompletely understood.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	124-132
32185675-3	2020	Here, we aimed to understand the direct role of intracellular iron-loading on hepcidin mRNA and peptide secretion using our previously characterised recombinant HepG2 cells that over-express the cell-surface iron-importer protein transferrin receptor-1.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	78-86
32185675-10	2020	This suggests a limited role of elevated intracellular iron in hepcidin secretion.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	63-71
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	46-48	ceruloplasmin	Homo sapiens	252-265
31671241-5	2020	Fe-regulated protein stability and nuclear localization of the upstream transcriptional regulator bHLH34 were uncovered.	Iron	0-2	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	98-104
31671241-6	2020	The C to T transition mutation resulting in substitution of alanine to valine at amino acid position 320 of bHLH34 (designated as IDT1A320V ) in a conserved motif among mono- and dicots was found to be responsible for a dominant phenotype that possesses constitutive activation of the Fe regulatory pathway.	Iron	285-287	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	108-114
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Iron	160-162	ceruloplasmin	Homo sapiens	54-67
3743768-4	1986	The occurrence of both gastrin and gastric transferrin in porcine gastric mucosa and lumen suggests a novel synergistic role for the observed interaction in the uptake of dietary iron.	Iron	179-183	gastrin	Homo sapiens	23-30
32336023-7	2020	By 60 minutes, notable changes included phosphosites significantly changing on p53 (P04637), CAD protein (P27708), and proteins important for iron homeostasis, such as FTH1 (P02794), HMOX1 (P09601), and PCBP1 (Q15365).	Iron	142-146	ferritin heavy chain 1	Homo sapiens	168-172
3010712-1	1986	Since the p97 antigen, a membrane-associated iron-binding protein, has extensive amino acid sequence with homology with transferrin, is functionally related to the transferrin receptor, and has been previously mapped to chromosome 3, we have performed additional studies for regional mapping of the gene expressing p97 antigen.	Iron	45-49	melanotransferrin	Homo sapiens	10-13
32239172-13	2020	We conclude that iron/heme overload in HH increases xanthine oxidase activity and also promotes p53 degradation resulting in decreased ABCG2 expression.	Iron	17-21	transformation related protein 53, pseudogene	Mus musculus	96-99
3754536-5	1986	p97 belongs to a superfamily of iron-binding proteins that have amino acid homology; other members of this family include transferrin (TF), lactotransferrin, and ovotransferrin.	Iron	32-36	melanotransferrin	Homo sapiens	0-3
32346034-7	2020	Using RNA-seq analysis, we identified that an iron uptake-associated gene, transferrin receptor, was upregulated in obese ob/ob mice with LVH.	Iron	46-50	leptin	Mus musculus	116-118
32349426-4	2020	Iron is essential for multiple cell functions and its homeostasis is regulated by the hepcidin-ferroportin axis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	86-94
2419904-8	1986	Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.	Iron	76-80	melanotransferrin	Homo sapiens	111-114
32349426-5	2020	Hepcidin (HEPC) is mainly produced by the liver in response to iron needs but is also an acute phase protein.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
32349426-5	2020	Hepcidin (HEPC) is mainly produced by the liver in response to iron needs but is also an acute phase protein.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	10-14
32349426-6	2020	During inflammation, hepcidin is upregulated by IL-6 and is responsible for iron compartmentalization within cells, in turn causing anemia of inflammation.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	21-29
32349426-7	2020	Tissues other than liver can produce hepcidin in response to inflammatory stimuli, in order to decrease iron efflux at a local level, then acting in an autocrine-paracrine manner.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	37-45
32349426-8	2020	In IBDs and, in particular, in celiac disease (CeD), IL-6 might trigger the expression, upregulation and secretion of hepcidin in the small intestine, reducing iron efflux and exacerbating defective iron absorption.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	118-126
32349426-8	2020	In IBDs and, in particular, in celiac disease (CeD), IL-6 might trigger the expression, upregulation and secretion of hepcidin in the small intestine, reducing iron efflux and exacerbating defective iron absorption.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	118-126
32349426-12	2020	Finally, considering that HEPC expression is regulated by iron needs, inflammation and estrogens, we explored the hypothesis that 7-HMR consumption could ameliorate anemia in CeD using Caco-2 cells as bowel model.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	26-30
3933852-1	1985	Colorimetry of iron in serum with Ferrozine (as used in the Technicon SMAC) or with bathophenanthroline (as used in the Du Pont aca) is influenced by EDTA, in contrast to such measurements with atomic absorption spectroscopy.	Iron	15-19	diablo IAP-binding mitochondrial protein	Homo sapiens	70-74
32383899-4	2020	We calibrate the sensor tip by deliberately coupling it to a well characterized Fe atom.	Iron	80-82	TOR signaling pathway regulator	Homo sapiens	24-27
32184317-4	2020	The airway tissue expression of the iron sequestration molecules divalent metal transporter 1 (DMT1) and transferrin receptor 1 (TFR1) are increased in asthma with TFR1 expression correlating with reduced lung function and increased type 2 (T2) inflammatory responses in the airways.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	65-93
32184317-4	2020	The airway tissue expression of the iron sequestration molecules divalent metal transporter 1 (DMT1) and transferrin receptor 1 (TFR1) are increased in asthma with TFR1 expression correlating with reduced lung function and increased type 2 (T2) inflammatory responses in the airways.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	95-99
4054239-1	1985	The effect of transferrin from various sources and the degree of saturation with iron on the stimulation of DNA synthesis by erythropoietin (Epo) has been investigated.	Iron	81-85	erythropoietin	Mus musculus	125-139
32203978-1	2020	Background: Inflammatory cytokines, such as interleukin (IL)-1beta, alter iron homeostasis and erythropoiesis, resulting in anemia, but whether inhibition of IL-1beta can reverse these effects is unclear.	Iron	74-78	interleukin 1 alpha	Homo sapiens	44-66
4054239-1	1985	The effect of transferrin from various sources and the degree of saturation with iron on the stimulation of DNA synthesis by erythropoietin (Epo) has been investigated.	Iron	81-85	erythropoietin	Mus musculus	141-144
4054239-2	1985	Mouse, human, and bovine transferrins saturated with iron caused an increase in thymidine incorporation both in the absence and presence of Epo.	Iron	53-57	erythropoietin	Bos taurus	140-143
32316587-0	2020	Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent.	Iron	84-88	erythroferrone	Homo sapiens	51-65
4054246-9	1985	Thus, either the iron-incorporating system of normal CFU-E was inducible by epo, or else epo permitted survival of the CFU-E so that the activity of a constitutive iron-incorporating system could be recognized.	Iron	17-21	erythropoietin	Mus musculus	76-79
32316587-0	2020	Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	66-74
2982836-3	1985	We provide evidence for the presence of three tetranuclear clusters and five or six binuclear clusters, accounting well for the chemically determined iron content of this enzyme (22-24 atoms/molecule of FMN).	Iron	150-154	formin 1	Homo sapiens	203-206
32316587-1	2020	Alterations in iron metabolism after physical activity are manifested through the rise of blood hepcidin (Hpc) levels.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	96-104
32316587-1	2020	Alterations in iron metabolism after physical activity are manifested through the rise of blood hepcidin (Hpc) levels.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	106-109
32316587-4	2020	EPO, ERFE and Hpc biosynthesis is modified by serum iron through transferrin receptor 2.	Iron	52-56	erythroferrone	Homo sapiens	5-9
32316587-4	2020	EPO, ERFE and Hpc biosynthesis is modified by serum iron through transferrin receptor 2.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	14-17
32316587-4	2020	EPO, ERFE and Hpc biosynthesis is modified by serum iron through transferrin receptor 2.	Iron	52-56	transferrin receptor 2	Homo sapiens	65-87
32316587-9	2020	In athletes whose serum iron levels were below 105 microg/day (n = 15), serum EPO (p = 0.00) and ERFE levels (p = 0.00) increased with no changes in Hpc concentration.	Iron	24-28	erythroferrone	Homo sapiens	97-101
6500058-0	1984	XANES study of iron displacement in the haem of myoglobin.	Iron	15-19	myoglobin	Homo sapiens	48-57
32316587-11	2020	Conversely, an increase in ERFE levels was observed in marathoners with low serum iron, independently of serum ferritin (n = 7).	Iron	82-86	erythroferrone	Homo sapiens	27-31
32316587-12	2020	This indicates modulation of blood iron may affect exercise-induced changes in the EPO/ERFE/Hpc axis.	Iron	35-39	erythroferrone	Homo sapiens	87-91
32316587-12	2020	This indicates modulation of blood iron may affect exercise-induced changes in the EPO/ERFE/Hpc axis.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	92-95
32316587-13	2020	Further study is needed to fully understand the physiological meaning of the interdependence between iron and the EPO/ERFE/Hpc axis.	Iron	101-105	erythroferrone	Homo sapiens	118-122
32316587-13	2020	Further study is needed to fully understand the physiological meaning of the interdependence between iron and the EPO/ERFE/Hpc axis.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	123-126
6437985-7	1984	The results of this study suggest that transferrin and ceruloplasmin may be synthesized partly in response to the altered iron metabolism observed during hypoferremia.	Iron	122-126	ceruloplasmin	Mus musculus	55-68
31911211-1	2020	Bovine lactoferrin (bLF) is an iron-binding glycoprotein used in functional and therapeutic products due to its biological properties, the most important being its antimicrobial activity.	Iron	31-35	lactotransferrin	Bos taurus	7-18
6091554-12	1984	This suggestion implies that the electron distribution of the iron at the catalytic sites of cytochrome P-450 and certain chlorin-containing enzymes is in some way similar, but distinct from that at the transport site of myoglobin.	Iron	62-66	myoglobin	Homo sapiens	221-230
6089085-7	1984	Neutrophil myeloperoxidase activity was slightly decreased in iron deficient rats and returned to normal after iron administration.	Iron	62-66	myeloperoxidase	Rattus norvegicus	11-26
32293336-7	2020	CONCLUSIONS: IDH1/2 mutation is a favorable predictor and may be related to iron metabolism in small duct type of ICCs.	Iron	76-80	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	13-19
6089085-7	1984	Neutrophil myeloperoxidase activity was slightly decreased in iron deficient rats and returned to normal after iron administration.	Iron	111-115	myeloperoxidase	Rattus norvegicus	11-26
32104855-0	2020	Iron-mediated interaction of alpha synuclein with lipid raft model membranes.	Iron	0-4	synuclein alpha	Homo sapiens	29-44
6726222-0	1984	Spectroscopic studies on the binding of iron, terbium, and zinc by apoferritin.	Iron	40-44	ferritin heavy chain 1	Homo sapiens	67-78
6325518-6	1984	Inhibition of two coliform strains by apo-lactoferrin (10 mg/ml) was abolished by addition of ferric iron to the assay system, indicating an iron-dependent nature of apo-lactoferrin induced inhibition of bacteria.	Iron	101-105	lactotransferrin	Bos taurus	42-53
32322334-1	2020	Ferroptosis, implicated in several diseases, is a new form of programmed and nonapoptotic cell death triggered by iron-dependent lipid peroxidation after inactivation of the cystine/glutamate antiporter system xc-, which is composed of solute carrier family 7 membrane 11 (SLC7A11) and solute carrier family 3 membrane 2 (SLC3A2).	Iron	114-118	solute carrier family 7 member 11	Homo sapiens	236-271
32322334-1	2020	Ferroptosis, implicated in several diseases, is a new form of programmed and nonapoptotic cell death triggered by iron-dependent lipid peroxidation after inactivation of the cystine/glutamate antiporter system xc-, which is composed of solute carrier family 7 membrane 11 (SLC7A11) and solute carrier family 3 membrane 2 (SLC3A2).	Iron	114-118	solute carrier family 7 member 11	Homo sapiens	273-280
32322334-1	2020	Ferroptosis, implicated in several diseases, is a new form of programmed and nonapoptotic cell death triggered by iron-dependent lipid peroxidation after inactivation of the cystine/glutamate antiporter system xc-, which is composed of solute carrier family 7 membrane 11 (SLC7A11) and solute carrier family 3 membrane 2 (SLC3A2).	Iron	114-118	solute carrier family 3 member 2	Homo sapiens	286-320
32322334-1	2020	Ferroptosis, implicated in several diseases, is a new form of programmed and nonapoptotic cell death triggered by iron-dependent lipid peroxidation after inactivation of the cystine/glutamate antiporter system xc-, which is composed of solute carrier family 7 membrane 11 (SLC7A11) and solute carrier family 3 membrane 2 (SLC3A2).	Iron	114-118	solute carrier family 3 member 2	Homo sapiens	322-328
6325518-6	1984	Inhibition of two coliform strains by apo-lactoferrin (10 mg/ml) was abolished by addition of ferric iron to the assay system, indicating an iron-dependent nature of apo-lactoferrin induced inhibition of bacteria.	Iron	101-105	lactotransferrin	Bos taurus	170-181
6707846-0	1984	Supplementation of milk with iron bound to lactoferrin using weanling mice.	Iron	29-33	lactotransferrin	Mus musculus	43-54
31248967-0	2020	Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.	Iron	98-102	glutathione peroxidase 4	Mus musculus	0-24
6371455-4	1984	Thus DMD should follow the usual experience of other examples of oxidative pathology, where the balance between tocopherol, the main antioxidant in membrane lipids, and non protein-bound iron, an important catalyst of reactions which produce oxidizing free radicals, largely determines whether or not tissue damage occurs.	Iron	187-191	dystrophin	Homo sapiens	5-8
33273799-1	2020	Previous studies attributed the origin of metal veins penetrating graphite nodules in the Canyon Diablo IAB main group iron meteorite to condensation from vapor or melting of host metal.	Iron	119-123	diablo IAP-binding mitochondrial protein	Homo sapiens	97-103
6691963-4	1984	Phenylhydrazine reacts with myoglobin in such a way that a phenyl group remains bound to the iron atom.	Iron	93-97	myoglobin	Homo sapiens	28-37
32061663-7	2020	Ferroptosis is the result of the loss of glutathione peroxidase 4 (GPX4) activity that transforms iron-dependent lipid hydroperoxides to lipid alcohols, which are inert in the biological environment.	Iron	98-102	glutathione peroxidase 4	Homo sapiens	41-65
32061663-7	2020	Ferroptosis is the result of the loss of glutathione peroxidase 4 (GPX4) activity that transforms iron-dependent lipid hydroperoxides to lipid alcohols, which are inert in the biological environment.	Iron	98-102	glutathione peroxidase 4	Homo sapiens	67-71
32223474-2	2022	During pregnancy, placental transport protein Divalent metal transporter1 (DMT1) plays a crucial role in transit of iron across placenta.	Iron	116-120	solute carrier family 11 member 2	Homo sapiens	46-73
32223474-2	2022	During pregnancy, placental transport protein Divalent metal transporter1 (DMT1) plays a crucial role in transit of iron across placenta.	Iron	116-120	solute carrier family 11 member 2	Homo sapiens	75-79
6141010-6	1984	Following iron loading, the periportal GGT-positive hepatocytes produced by BHT accumulated cellular iron, whereas the cells in FAA-induced lesions excluded iron.	Iron	10-14	gamma-glutamyltransferase 1	Rattus norvegicus	39-42
32108853-0	2020	Interaction of alpha-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson"s disease.	Iron	45-49	synuclein alpha	Homo sapiens	15-30
32108853-2	2020	This study has demonstrated that iron in varying concentrations (up to 400 microM) causes an increase in alpha-synuclein content in SH-SY5Y cells associated with mitochondrial depolarization, decreased cellular ATP content and loss of cell viability during incubation up to 96 h. Knocking-down alpha-synuclein expression prevents cytotoxic actions of iron, which can also be prevented by cyclosporine A (a blocker of mitochondrial permeability transition pore).	Iron	33-37	synuclein alpha	Homo sapiens	105-120
32108853-2	2020	This study has demonstrated that iron in varying concentrations (up to 400 microM) causes an increase in alpha-synuclein content in SH-SY5Y cells associated with mitochondrial depolarization, decreased cellular ATP content and loss of cell viability during incubation up to 96 h. Knocking-down alpha-synuclein expression prevents cytotoxic actions of iron, which can also be prevented by cyclosporine A (a blocker of mitochondrial permeability transition pore).	Iron	33-37	synuclein alpha	Homo sapiens	294-309
32108853-2	2020	This study has demonstrated that iron in varying concentrations (up to 400 microM) causes an increase in alpha-synuclein content in SH-SY5Y cells associated with mitochondrial depolarization, decreased cellular ATP content and loss of cell viability during incubation up to 96 h. Knocking-down alpha-synuclein expression prevents cytotoxic actions of iron, which can also be prevented by cyclosporine A (a blocker of mitochondrial permeability transition pore).	Iron	351-355	synuclein alpha	Homo sapiens	105-120
32108853-3	2020	These results indicate that iron cytotoxicity is mediated by alpha-synuclein acting on mitochondria.	Iron	28-32	synuclein alpha	Homo sapiens	61-76
32108853-6	2020	Our results tend to suggest that iron inactivates Parkin in SH-SY5Y cells and thereby inhibits the proteasomal degradation of alpha-synuclein, and the accumulated alpha-synuclein causes mitochondrial dysfunction and cell death.	Iron	33-37	synuclein alpha	Homo sapiens	126-141
6141010-6	1984	Following iron loading, the periportal GGT-positive hepatocytes produced by BHT accumulated cellular iron, whereas the cells in FAA-induced lesions excluded iron.	Iron	101-105	gamma-glutamyltransferase 1	Rattus norvegicus	39-42
6141010-6	1984	Following iron loading, the periportal GGT-positive hepatocytes produced by BHT accumulated cellular iron, whereas the cells in FAA-induced lesions excluded iron.	Iron	101-105	gamma-glutamyltransferase 1	Rattus norvegicus	39-42
6653779-1	1983	The protein component of the iron storage molecule, ferritin, contains 24 subunits in form of a hollow shell known as apoferritin.	Iron	29-33	ferritin heavy chain 1	Homo sapiens	118-129
31973819-5	2020	In addition, LY294002 also inhibited the basal expression of HEPH and FPN1 resulting in blockade of iron egress from cells.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	70-74
31884370-3	2020	The reduction of Fe(III) to Fe(II), decomposition of PMS, and degradation/mineralization of 4-chlorophenol (4-CP) are all accelerated in the Mo/Fe2+/PMS process at a very low Fe2+/PMS ratio (Fe2+/PMS = 1/10).	Iron	144-148	PMS1 homolog 1, mismatch repair system component	Homo sapiens	196-203
6644450-7	1983	These results show that lactoferrin may be a useful vehicle for supplementation of iron.	Iron	83-87	lactotransferrin	Mus musculus	24-35
6579541-5	1983	Of the two highly conserved cysteinyl peptides in P-450LM2, P-450b, and bacterial P-450cam, we favor, on the basis of our model, the one nearer the NH2 terminus (Cys-152 in P-450LM2) as the source of the thiolate ligand to the heme iron atom.	Iron	232-236	cytochrome P450 2B4	Oryctolagus cuniculus	50-58
32155272-5	2020	RESULTS: The results of the studies we found suggest that cardiac hepcidin is a major regulator of iron homeostasis in cardiac tissue.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	66-74
32155272-8	2020	Upregulation of cardiac hepcidin in hypoxia preserves cardiomyocytes from forming out of reactive oxygen species catalyzed by free cellular iron in cardiomyocytes.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	24-32
6579541-5	1983	Of the two highly conserved cysteinyl peptides in P-450LM2, P-450b, and bacterial P-450cam, we favor, on the basis of our model, the one nearer the NH2 terminus (Cys-152 in P-450LM2) as the source of the thiolate ligand to the heme iron atom.	Iron	232-236	cytochrome P450 2B4	Oryctolagus cuniculus	173-181
6688622-10	1983	Manganese inhibits ferrochelatase competitively with respect to iron (Ki = 15 microM) and noncompetitively with respect to the porphyrin substrate.	Iron	64-68	FECH	Bos taurus	19-33
32210768-14	2020	Following the up-regulation of ferritin mediated by alpha-syn, hepcidin-to-ferritin levels were indicative of modulatory effects in alpha-syn-treated astrocytes with altered iron status.	Iron	174-178	hepcidin antimicrobial peptide	Homo sapiens	63-71
32210768-14	2020	Following the up-regulation of ferritin mediated by alpha-syn, hepcidin-to-ferritin levels were indicative of modulatory effects in alpha-syn-treated astrocytes with altered iron status.	Iron	174-178	synuclein alpha	Homo sapiens	132-141
32210768-15	2020	Therefore, we propose that the hepcidin-to-ferritin ratio is indicative of a detrimental response in primary cultured astrocytes experiencing iron and extracellular alpha-syn.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	31-39
32182331-0	2020	TGFbeta2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	9-17
32182331-3	2020	Smad4, an essential co-Smad, upregulates hepcidin, the master regulator of iron homeostasis.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	41-49
6688622-12	1983	These findings lead to a sequential Bi Bi kinetic model for ferrochelatase with iron binding occurring prior to porphyrin binding and heme being released prior to the release of two protons.	Iron	80-84	FECH	Bos taurus	60-74
6349699-0	1983	The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum.	Iron	73-77	lactotransferrin	Bos taurus	100-111
32027058-2	2020	Herein, it is discovered that organic small molecule (hexabromobenzene, HBB) can activate commercial transition metal (Ni, Fe, and NiFe) foam by directly evolving metal nanomeshes embedded in graphene-like films (M-NM@G) through a facile Br-induced solid-phase migration process.	Iron	123-125	hemoglobin subunit beta	Homo sapiens	72-75
6349699-3	1983	Neither enzyme had much effect on the lactoferrin-mediated antimicrobial activity of human milk, and the iron binding capacity of lactoferrin in the milk was only slightly reduced.	Iron	105-109	lactotransferrin	Bos taurus	130-141
32020293-8	2020	Therefore, in Cyt with C2 and C3, less intensive reduction of hem iron leaves more unoccupied target residues for Ru coordination, leading to more efficient formation of covalent adducts, in comparison to C1 and C4.	Iron	66-70	complement C2	Homo sapiens	23-32
32020293-8	2020	Therefore, in Cyt with C2 and C3, less intensive reduction of hem iron leaves more unoccupied target residues for Ru coordination, leading to more efficient formation of covalent adducts, in comparison to C1 and C4.	Iron	66-70	complement C4A (Rodgers blood group)	Homo sapiens	205-214
6349699-4	1983	Likewise both enzymes had only a slight effect on the iron-binding capacity of purified lactoferrin.	Iron	54-58	lactotransferrin	Bos taurus	88-99
31850660-0	2020	A step toward an expanded iron toolkit: Hepcidin values in healthy Dutch children.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	40-48
6349699-5	1983	Although iron-free (apo)lactoferrin was slightly more susceptible to digestion, especially by chymotrypsin, than the iron-saturated form, the difference was much less than has been found in earlier studies with other proteins of the transferrin class.	Iron	9-13	lactotransferrin	Bos taurus	24-35
6312890-1	1983	Periodate treatments of apo human serum transferrin (HST), and apo chicken ovotransferrin (COT) were previously reported to cause a rapid loss of Fe+3 binding capacity, with a loss of 3 to 5 tyrosine residues [P. AZARI AND J. L. PHILLIPS (1970) Arch.	Iron	146-148	transferrin (ovotransferrin)	Gallus gallus	34-51
31991168-7	2020	More recent in vitro and animal studies have elucidated the complex signaling pathways regulating iron, with a particular focus on hepcidin, the master regulator of body iron homeostasis.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	131-139
6312890-1	1983	Periodate treatments of apo human serum transferrin (HST), and apo chicken ovotransferrin (COT) were previously reported to cause a rapid loss of Fe+3 binding capacity, with a loss of 3 to 5 tyrosine residues [P. AZARI AND J. L. PHILLIPS (1970) Arch.	Iron	146-148	transferrin (ovotransferrin)	Gallus gallus	75-89
31991168-7	2020	More recent in vitro and animal studies have elucidated the complex signaling pathways regulating iron, with a particular focus on hepcidin, the master regulator of body iron homeostasis.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	131-139
31991168-8	2020	Bone morphogenetic protein (BMP) signaling is the major pathway that is required for induction of hepcidin expression in response to increasing levels of iron.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	98-106
6138291-2	1983	These iron-resistant acinar cell lesions coincided rather well with the lesions having markedly decreased activity of gamma-glutamyl transpeptidase.	Iron	6-10	gamma-glutamyltransferase 1	Rattus norvegicus	118-147
31724666-7	2020	Compared to DiDBV2 without iron oxide activation, DiDBV2-Fe indicated strong tumor tropism in response to monocyte chemoattractant protein-1 (CCL2) secreted by U87MG tumor cells.	Iron	50-59	C-C motif chemokine ligand 2	Homo sapiens	106-140
31724666-7	2020	Compared to DiDBV2 without iron oxide activation, DiDBV2-Fe indicated strong tumor tropism in response to monocyte chemoattractant protein-1 (CCL2) secreted by U87MG tumor cells.	Iron	50-59	C-C motif chemokine ligand 2	Homo sapiens	142-146
6304037-0	1983	Preferred sites for electron transfer between cytochrome c and iron and cobalt complexes.	Iron	63-67	cytochrome c, somatic	Equus caballus	46-58
32081948-0	2020	Hepcidin-mediated Iron Regulation in P19 Cells is Detectable by Magnetic Resonance Imaging.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
32081948-3	2020	In hepcidin-mediated inflammation, for example, downregulation of iron export in monocytes and macrophages involves post-translational degradation of ferroportin.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	3-11
6600950-2	1983	Fully iron-saturated lactoferrin suppressed the numbers of granulocytes and monocytes per femur, the numbers of granulocyte-macrophage progenitor cells (CFU-GM) per femur and spleen, and decreased the cycle status of femoral and splenic CFU-GM.	Iron	6-10	lactotransferrin	Mus musculus	21-32
32081948-8	2020	Under varying conditions of iron supplementation, the level of ferroportin in P19 cells responds to hepcidin regulation, consistent with degradation through a ubiquitin-mediated pathway.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	100-108
32081948-10	2020	The correlation between total cellular iron content and MR transverse relaxation rates was different in hepcidin-treated and untreated P19 cells: slope, Pearson correlation coefficient and relaxation rate were all affected.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	104-112
32081948-11	2020	These findings may provide a tool to non-invasively distinguish changes in endogenous iron contrast arising from hepcidin-ferroportin interactions, with potential utility in monitoring of different macrophage phenotypes involved in pro- and anti-inflammatory signaling.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	113-121
6600950-9	1983	Heat-treated lactoferrin, inactive in vitro, was inactive in vivo, but iron-depleted (apo-) lactoferrin, inactive in vitro, was active in vivo, suggesting that the apo-lactoferrin acquired the iron in vivo that was necessary to change it into an active form.	Iron	71-75	lactotransferrin	Mus musculus	92-103
32079434-9	2022	Serum hepcidin, transferrin saturationand MDA/FRAP ratio is useful in differentiating pre-eclampsia patients from healthy pregnant women.Conclusion: Iron supplementation in preeclampsia patients might have led to a state of iron overload, which might have caused oxidative stress and endothelial dysfunction in preeclampsia patients.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	6-14
6600950-9	1983	Heat-treated lactoferrin, inactive in vitro, was inactive in vivo, but iron-depleted (apo-) lactoferrin, inactive in vitro, was active in vivo, suggesting that the apo-lactoferrin acquired the iron in vivo that was necessary to change it into an active form.	Iron	71-75	lactotransferrin	Mus musculus	92-103
32079434-10	2022	The rise in hepcidin levels in this scenario may be viewed as a protective mechanism to combat the iron overload mediated cytotoxicity.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	12-20
6655984-2	1983	Rimington proposed a hypothesis that lead interferes with a specific enzyme (ferrochelatase) system, which is responsible for incorporating iron into the protoporphyrin IX molecules to form heme.	Iron	140-144	ferrochelatase, mitochondrial	Oryctolagus cuniculus	77-91
31981721-1	2020	BACKGROUND: We investigated the anti-inflammatory effect of type II cannabinoid receptor (CB2 receptor) activation and their relationship to iron influx on 1-methyl-4-phenylpyridinium (MPP+) treated astrocytes.	Iron	141-145	cannabinoid receptor 2	Homo sapiens	90-93
31981721-8	2020	CONCLUSIONS: These results suggest that activation of CB2 receptor inhibit MPP+-induced inflammatory response and iron influx in astrocytes.	Iron	114-118	cannabinoid receptor 2	Homo sapiens	54-57
6679774-2	1983	The addition of cytochrome b5 to cytochrome P-450 results in transition of cytochrome P-450 heme iron from low to high spin state.	Iron	97-101	cytochrome b	Oryctolagus cuniculus	16-28
31724192-10	2020	In conclusion, NMBR natural variants were enriched in patients with iron overload, and associated with facilitated iron absorption, possibly related to a defect of iron-induced hepcidin release.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	177-185
31724192-10	2020	In conclusion, NMBR natural variants were enriched in patients with iron overload, and associated with facilitated iron absorption, possibly related to a defect of iron-induced hepcidin release.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	177-185
31737919-0	2020	Gain-of-function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway.	Iron	61-65	piezo type mechanosensitive ion channel component 1	Homo sapiens	30-36
31737919-5	2020	In two hepatic cellular models expressing PIEZO1 WT and two PIEZO1 gain-of-function mutants (R2456H and R2488Q), we highlight altered expression of a few genes/proteins involved in iron metabolism.	Iron	181-185	piezo type mechanosensitive ion channel component 1	Homo sapiens	42-48
31737919-5	2020	In two hepatic cellular models expressing PIEZO1 WT and two PIEZO1 gain-of-function mutants (R2456H and R2488Q), we highlight altered expression of a few genes/proteins involved in iron metabolism.	Iron	181-185	piezo type mechanosensitive ion channel component 1	Homo sapiens	60-66
31737919-11	2020	This is the first demonstration of a direct link between PIEZO1 and iron metabolism, which defines the channel as a new hepatic iron metabolism regulator and as a possible therapeutic target of iron overload in DHS and other iron-loading anemias.	Iron	68-72	piezo type mechanosensitive ion channel component 1	Homo sapiens	57-63
31737919-11	2020	This is the first demonstration of a direct link between PIEZO1 and iron metabolism, which defines the channel as a new hepatic iron metabolism regulator and as a possible therapeutic target of iron overload in DHS and other iron-loading anemias.	Iron	128-132	piezo type mechanosensitive ion channel component 1	Homo sapiens	57-63
31737919-11	2020	This is the first demonstration of a direct link between PIEZO1 and iron metabolism, which defines the channel as a new hepatic iron metabolism regulator and as a possible therapeutic target of iron overload in DHS and other iron-loading anemias.	Iron	128-132	piezo type mechanosensitive ion channel component 1	Homo sapiens	57-63
31737919-11	2020	This is the first demonstration of a direct link between PIEZO1 and iron metabolism, which defines the channel as a new hepatic iron metabolism regulator and as a possible therapeutic target of iron overload in DHS and other iron-loading anemias.	Iron	128-132	piezo type mechanosensitive ion channel component 1	Homo sapiens	57-63
6617868-2	1983	Ovotransferrin, an iron-binding glycoprotein of Mr 80 000, is also shown to stimulate in vitro myogenesis of cultured chick embryo myotubes as measured by saturable dose-dependent increase in acetylcholine receptors.	Iron	19-23	transferrin (ovotransferrin)	Gallus gallus	0-14
31666189-1	2020	Iron accumulation has been frequently found in atherosclerotic lesions, especially in macrophages/foam cells, but the exact mechanisms by which hepcidin induces iron retention in plaque macrophages and its roles in atherogenesis remain unknown.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	144-152
31666189-4	2020	Ox-LDL-induced iron retention and lipid accumulation were aggravated by lipopolysaccharide but blocked by TAK-242, an antagonist of TLR4.	Iron	15-19	toll like receptor 4	Homo sapiens	132-136
31666189-5	2020	Moreover, macrophage TLR4/NF-kappaB pathway activation and foaming triggered by ox-LDL was enhanced by ferric ammonium citrate or exogenous hepcidin but attenuated by hepcidin silencing or the use of iron chelator.	Iron	200-204	toll like receptor 4	Homo sapiens	21-25
6617868-3	1983	This effect is probably dependent on ovotransferrin"s ability to donate iron to the cells.	Iron	72-76	transferrin (ovotransferrin)	Gallus gallus	37-51
31666189-5	2020	Moreover, macrophage TLR4/NF-kappaB pathway activation and foaming triggered by ox-LDL was enhanced by ferric ammonium citrate or exogenous hepcidin but attenuated by hepcidin silencing or the use of iron chelator.	Iron	200-204	hepcidin antimicrobial peptide	Homo sapiens	167-175
31666189-7	2020	Our study provided the evidence that iron trapped in atherosclerosis plaque macrophages contributes to cholesterol disequilibrium-initiated foam cell formation, which is provoked by the unique but largely unknown autocrine formation of hepcidin in plaque macrophages via activating the TLR4/NF-kappaB pathway when exposed to ox-LDL.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	236-244
6685969-2	1983	Their levels of retinol and RBP correlated positively and significantly with transferrin, iron, total iron binding capacity (TIBC), total proteins and albumin.	Iron	90-94	SURP and G-patch domain containing 1	Homo sapiens	28-31
31666189-7	2020	Our study provided the evidence that iron trapped in atherosclerosis plaque macrophages contributes to cholesterol disequilibrium-initiated foam cell formation, which is provoked by the unique but largely unknown autocrine formation of hepcidin in plaque macrophages via activating the TLR4/NF-kappaB pathway when exposed to ox-LDL.	Iron	37-41	toll like receptor 4	Homo sapiens	286-290
31666189-8	2020	Such findings, considering the intricate vicious cycle between macrophage hepcidin autocrine-triggered iron retention and cholesterol disequilibrium, may shed new light on the "iron hypothesis" of atherosclerosis.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	74-82
31666189-8	2020	Such findings, considering the intricate vicious cycle between macrophage hepcidin autocrine-triggered iron retention and cholesterol disequilibrium, may shed new light on the "iron hypothesis" of atherosclerosis.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	74-82
6685969-2	1983	Their levels of retinol and RBP correlated positively and significantly with transferrin, iron, total iron binding capacity (TIBC), total proteins and albumin.	Iron	102-106	SURP and G-patch domain containing 1	Homo sapiens	28-31
6818832-4	1982	When a cow"s milk diet supplemented by partially or completely iron-saturated human or bovine lactotransferrin was fed to the babies, the amounts of copro-lactotransferrin excreted depended on the origin and on the iron saturation of the lactoransferrin.	Iron	63-67	lactotransferrin	Bos taurus	155-171
31823109-3	2020	In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblot techniques, which demonstrated that iron deposition is associated with increased levels of nuclear prelamin A recognition factor (NARF).	Iron	178-182	nuclear prelamin A recognition factor	Mus musculus	233-270
31823109-3	2020	In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblot techniques, which demonstrated that iron deposition is associated with increased levels of nuclear prelamin A recognition factor (NARF).	Iron	178-182	nuclear prelamin A recognition factor	Mus musculus	272-276
6818832-4	1982	When a cow"s milk diet supplemented by partially or completely iron-saturated human or bovine lactotransferrin was fed to the babies, the amounts of copro-lactotransferrin excreted depended on the origin and on the iron saturation of the lactoransferrin.	Iron	215-219	lactotransferrin	Bos taurus	155-171
7056714-2	1982	Iron-transferring activity of iron-binding fragments of ovotransferrin with chicken embryo red cells.	Iron	0-4	transferrin (ovotransferrin)	Gallus gallus	56-70
31772327-4	2020	Here, we show that ABC transporter subfamily B member 7 (ABCB7), one of the mitochondrial iron transporters, induces the hypoxia-independent accumulation of hypoxia-inducible factor 1 alpha by controlling intracellular iron homeostasis and inhibits both apoptotic and non-apoptotic cell death.	Iron	90-94	ATP binding cassette subfamily B member 7	Homo sapiens	57-62
31772327-4	2020	Here, we show that ABC transporter subfamily B member 7 (ABCB7), one of the mitochondrial iron transporters, induces the hypoxia-independent accumulation of hypoxia-inducible factor 1 alpha by controlling intracellular iron homeostasis and inhibits both apoptotic and non-apoptotic cell death.	Iron	219-223	ATP binding cassette subfamily B member 7	Homo sapiens	57-62
31772327-7	2020	Therefore, our results support that ABCB7 is crucial in controlling both apoptotic and non-apoptotic cell death and indicate that the fine-tuning of intracellular iron homeostasis may be a novel anticancer strategy.	Iron	163-167	ATP binding cassette subfamily B member 7	Homo sapiens	36-41
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	147-153
7056714-2	1982	Iron-transferring activity of iron-binding fragments of ovotransferrin with chicken embryo red cells.	Iron	30-34	transferrin (ovotransferrin)	Gallus gallus	56-70
7056714-3	1982	The iron-transferring activity of iron-binding fragments FeNF and FeCF, representing the NH2- and CO2H-terminal domains of iron-ovotransferrin (Fe2OT), with a chicken embryo red cell system, was investigated.	Iron	4-8	transferrin (ovotransferrin)	Gallus gallus	128-142
7056714-3	1982	The iron-transferring activity of iron-binding fragments FeNF and FeCF, representing the NH2- and CO2H-terminal domains of iron-ovotransferrin (Fe2OT), with a chicken embryo red cell system, was investigated.	Iron	34-38	transferrin (ovotransferrin)	Gallus gallus	128-142
31949017-0	2020	Iron metabolism and iron disorders revisited in the hepcidin era.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	52-60
31949017-3	2020	The master regulator of systemic iron homeostasis is the liver peptide hepcidin, which controls serum iron through degradation of ferroportin in iron absorptive enterocytes and iron recycling macrophages.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	71-79
6952215-6	1982	Those events of erythroid differentiation shown to be directed by EP were extrusion of the nucleus from the erythroblast, induction of uroporphyrinogen I synthetase activity, increased iron incorporation into protoporphyrin, synthesis of alpha- and beta-globin polypeptides due largely to increased mRNA production, and synthesis and incorporation of spectrin into the cell membrane.	Iron	185-189	erythropoietin	Mus musculus	66-68
31949017-3	2020	The master regulator of systemic iron homeostasis is the liver peptide hepcidin, which controls serum iron through degradation of ferroportin in iron absorptive enterocytes and iron recycling macrophages.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	71-79
31949017-3	2020	The master regulator of systemic iron homeostasis is the liver peptide hepcidin, which controls serum iron through degradation of ferroportin in iron absorptive enterocytes and iron recycling macrophages.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	71-79
31949017-3	2020	The master regulator of systemic iron homeostasis is the liver peptide hepcidin, which controls serum iron through degradation of ferroportin in iron absorptive enterocytes and iron recycling macrophages.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	71-79
31949017-5	2020	Insufficient hepcidin production is central to iron overload while hepcidin excess lead to iron restriction.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	13-21
31949017-5	2020	Insufficient hepcidin production is central to iron overload while hepcidin excess lead to iron restriction.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	67-75
31949017-6	2020	Mutations of hemochromatosis genes result in iron excess by downregulating the liver BMP/SMAD signaling pathway.	Iron	45-49	bone morphogenetic protein 1	Homo sapiens	85-88
7271024-4	1981	In addition, a disordered iron metabolism was evidenced by depressed serum iron concentrations, total iron binding capacity (transferrin), percentage saturation of transferrin, and decreased numbers of bone marrow sideroblasts.	Iron	26-30	inhibitor of carbonic anhydrase	Canis lupus familiaris	125-136
31949017-7	2020	In iron loading anemias as beta-thalassemia an enhanced albeit ineffective erythropoiesis releases erythroferrone that sequesters the BMP receptor ligand BMPs, thereby inhibiting hepcidin.	Iron	3-7	bone morphogenetic protein 1	Homo sapiens	134-137
31949017-7	2020	In iron loading anemias as beta-thalassemia an enhanced albeit ineffective erythropoiesis releases erythroferrone that sequesters the BMP receptor ligand BMPs, thereby inhibiting hepcidin.	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	179-187
31949017-8	2020	In Iron-Refractory Iron-Deficiency Anemia mutations of the hepcidin inhibitor TMPRSS6 upregulates the BMP/SMAD pathway.	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	59-67
31949017-8	2020	In Iron-Refractory Iron-Deficiency Anemia mutations of the hepcidin inhibitor TMPRSS6 upregulates the BMP/SMAD pathway.	Iron	3-7	bone morphogenetic protein 1	Homo sapiens	102-105
31949017-9	2020	Interleukin-6 in acute and chronic inflammation, increases hepcidin levels causing iron-restricted erythropoiesis and anemia of inflammation in the presence of iron replete macrophages.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	59-67
31949017-11	2020	Moreover it is leading to the development of targeted therapies for iron overload and inflammation, mainly centered on the manipulation of the hepcidin-ferroportin axis.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	143-151
31721323-0	2020	Fe doped CoP flower-like microstructure on carbon membrane as integrated electrode with enhanced sodium ion storage.	Iron	0-2	caspase recruitment domain family member 16	Homo sapiens	9-12
7271024-4	1981	In addition, a disordered iron metabolism was evidenced by depressed serum iron concentrations, total iron binding capacity (transferrin), percentage saturation of transferrin, and decreased numbers of bone marrow sideroblasts.	Iron	26-30	inhibitor of carbonic anhydrase	Canis lupus familiaris	164-175
31721323-3	2020	Considering those strategies, we designed the flower-like Fe doped CoP consisted of the micro sheets grown on the carbon membrane (CM, the leaves as precursor) by hydrothermal method and in-situ phosphorization.	Iron	58-60	caspase recruitment domain family member 16	Homo sapiens	67-70
7342412-6	1981	The laboratory features of a moderate anemia, normal bone marrow cellular pattern, depression iron metabolism and reticuloendothelial iron sequestration make a final diagnosis of AID dependent on ruling out other etiologic mechanisms which may obscure or aggravate the anemia of the inflammatory disease in the dog.	Iron	94-98	activation induced cytidine deaminase	Canis lupus familiaris	179-182
31721323-6	2020	The hierarchical Fe doped CoP directly grown on the carbon membrane could increase the active sites for sodium species intercalation and further promote the internal electron conduction in the Fe doped CoP/CM electrode.	Iron	17-19	caspase recruitment domain family member 16	Homo sapiens	26-29
31721323-6	2020	The hierarchical Fe doped CoP directly grown on the carbon membrane could increase the active sites for sodium species intercalation and further promote the internal electron conduction in the Fe doped CoP/CM electrode.	Iron	17-19	caspase recruitment domain family member 16	Homo sapiens	202-205
31721323-6	2020	The hierarchical Fe doped CoP directly grown on the carbon membrane could increase the active sites for sodium species intercalation and further promote the internal electron conduction in the Fe doped CoP/CM electrode.	Iron	193-195	caspase recruitment domain family member 16	Homo sapiens	26-29
31721323-6	2020	The hierarchical Fe doped CoP directly grown on the carbon membrane could increase the active sites for sodium species intercalation and further promote the internal electron conduction in the Fe doped CoP/CM electrode.	Iron	193-195	caspase recruitment domain family member 16	Homo sapiens	202-205
31721323-7	2020	Thereby, the Fe doped CoP/CM as anode electrode for sodium ion batteries exhibits high specific capacity of 515 mAh g-1 at 100 mA g-1 after 100 cycles.	Iron	13-15	caspase recruitment domain family member 16	Homo sapiens	22-25
31336386-1	2020	Neogenin is a transmembrane receptor critical for multiple cellular processes, including neurogenesis, astrogliogenesis, endochondral bone formation, and iron homeostasis.	Iron	154-158	neogenin	Mus musculus	0-8
6970054-7	1981	In all experimental situations, highly purified, iron-saturated LF in concentrations up to 10(-7) M had no effect on in vitro granulopoiesis.	Iron	49-53	lactotransferrin	Mus musculus	64-66
31900363-6	2020	Fortuitously, the SNCA mRNA has a structured iron-responsive element (IRE) in its 5" untranslated region (5" UTR) that controls its translation.	Iron	45-49	synuclein alpha	Homo sapiens	18-22
7459277-1	1981	Serum concentrations of myoglobin are significantly lower in iron-deficient than in non-iron-deficient children.	Iron	61-65	myoglobin	Homo sapiens	24-33
31708445-5	2020	Using a high-throughput screen of microbial metabolites, we found that gut microbiota produce metabolites that suppress hypoxia-inducible factor 2alpha (HIF-2alpha) a master transcription factor of intestinal iron absorption and increase the iron-storage protein ferritin, resulting in decreased intestinal iron absorption by the host.	Iron	209-213	endothelial PAS domain protein 1	Homo sapiens	120-151
31708445-5	2020	Using a high-throughput screen of microbial metabolites, we found that gut microbiota produce metabolites that suppress hypoxia-inducible factor 2alpha (HIF-2alpha) a master transcription factor of intestinal iron absorption and increase the iron-storage protein ferritin, resulting in decreased intestinal iron absorption by the host.	Iron	209-213	endothelial PAS domain protein 1	Homo sapiens	153-163
31708445-5	2020	Using a high-throughput screen of microbial metabolites, we found that gut microbiota produce metabolites that suppress hypoxia-inducible factor 2alpha (HIF-2alpha) a master transcription factor of intestinal iron absorption and increase the iron-storage protein ferritin, resulting in decreased intestinal iron absorption by the host.	Iron	242-246	endothelial PAS domain protein 1	Homo sapiens	120-151
7459277-1	1981	Serum concentrations of myoglobin are significantly lower in iron-deficient than in non-iron-deficient children.	Iron	88-92	myoglobin	Homo sapiens	24-33
31708445-5	2020	Using a high-throughput screen of microbial metabolites, we found that gut microbiota produce metabolites that suppress hypoxia-inducible factor 2alpha (HIF-2alpha) a master transcription factor of intestinal iron absorption and increase the iron-storage protein ferritin, resulting in decreased intestinal iron absorption by the host.	Iron	242-246	endothelial PAS domain protein 1	Homo sapiens	153-163
7459277-2	1981	In the iron-deficient subjects there is a correlation between haemoglobin concentration and serum myoglobin suggesting that the synthesis of both haem compounds is affected in parallel.	Iron	7-11	myoglobin	Homo sapiens	98-107
31708445-5	2020	Using a high-throughput screen of microbial metabolites, we found that gut microbiota produce metabolites that suppress hypoxia-inducible factor 2alpha (HIF-2alpha) a master transcription factor of intestinal iron absorption and increase the iron-storage protein ferritin, resulting in decreased intestinal iron absorption by the host.	Iron	242-246	endothelial PAS domain protein 1	Homo sapiens	120-151
31708445-5	2020	Using a high-throughput screen of microbial metabolites, we found that gut microbiota produce metabolites that suppress hypoxia-inducible factor 2alpha (HIF-2alpha) a master transcription factor of intestinal iron absorption and increase the iron-storage protein ferritin, resulting in decreased intestinal iron absorption by the host.	Iron	242-246	endothelial PAS domain protein 1	Homo sapiens	153-163
7459282-4	1981	The effect of erythropoietin, with or without transferrin-iron is blocked by pre-incubation of the erythropoietin with rabbit anti erythropoietin serum.	Iron	58-62	erythropoietin	Mus musculus	99-113
7459282-4	1981	The effect of erythropoietin, with or without transferrin-iron is blocked by pre-incubation of the erythropoietin with rabbit anti erythropoietin serum.	Iron	58-62	erythropoietin	Mus musculus	99-113
7459282-5	1981	Human sera contain factors in addition to erythropoietin and transferin-iron which may modify the stimulation of incorporation of 3H-thymidine into fetal mouse liver DNA induced by erythropoietin.	Iron	72-76	erythropoietin	Mus musculus	181-195
6258647-3	1981	Under a constant concentration of anion, the redox reaction of various types of cytochrome c with iron hexacyanides was analyzed according to the scheme: (see formula in text) where C(III) and C(II) are ferric and ferrous cytochromes, respectively, Fe(III) and Fe(II) are ferri- and ferrocyanides, respectively, C(III) .	Iron	249-251	cytochrome c, somatic	Equus caballus	80-92
31740582-0	2020	Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1.	Iron	98-102	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	142-147
31740582-3	2020	We considered that up-regulation of these genes attenuates ferroptosis induction and found that the transcription factor BTB domain and CNC homolog 1 (BACH1), a regulator in heme and iron metabolism, promotes ferroptosis by repressing the transcription of a subset of the erastin-induced protective genes.	Iron	183-187	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	151-156
31674058-12	2020	A shift in mean serum hepcidin peaks followed administration of all iron-lowering doses of VIT-2763.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	22-30
7225438-3	1981	While removing iron and labile sulphur from ferredoxin reaction center the reduction wave of Fe-S bonds with E 1/2 = -0.33 V (N. H. E.) transforms into the reduction wave of S-S bonds with E 1/2 = -0,39 V at pH = 7.	Iron	15-19	RNA, U105B small nucleolar	Homo sapiens	109-119
7225438-3	1981	While removing iron and labile sulphur from ferredoxin reaction center the reduction wave of Fe-S bonds with E 1/2 = -0.33 V (N. H. E.) transforms into the reduction wave of S-S bonds with E 1/2 = -0,39 V at pH = 7.	Iron	15-19	RNA, U105B small nucleolar	Homo sapiens	189-199
31834456-2	2020	The recently discovered erythroid regulator, erythroferrone (ERFE), governed by high levels of erythropoietin, was found to suppress hepcidin expression, thus increasing iron availability for developing erythroid progenitors.	Iron	170-174	erythroferrone	Homo sapiens	61-65
7225438-3	1981	While removing iron and labile sulphur from ferredoxin reaction center the reduction wave of Fe-S bonds with E 1/2 = -0.33 V (N. H. E.) transforms into the reduction wave of S-S bonds with E 1/2 = -0,39 V at pH = 7.	Iron	93-95	RNA, U105B small nucleolar	Homo sapiens	109-119
31834456-2	2020	The recently discovered erythroid regulator, erythroferrone (ERFE), governed by high levels of erythropoietin, was found to suppress hepcidin expression, thus increasing iron availability for developing erythroid progenitors.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	133-141
7225438-3	1981	While removing iron and labile sulphur from ferredoxin reaction center the reduction wave of Fe-S bonds with E 1/2 = -0.33 V (N. H. E.) transforms into the reduction wave of S-S bonds with E 1/2 = -0,39 V at pH = 7.	Iron	93-95	RNA, U105B small nucleolar	Homo sapiens	189-199
31834456-3	2020	We aimed to investigate ERFE levels in Egyptian beta-TM patients as an attempt to understand its role in the prediction of iron overload states.	Iron	123-127	erythroferrone	Homo sapiens	24-28
31834456-6	2020	Both ERFE gene expression levels and transferrin saturation (TS%) values were able to discriminate among cases with different degrees of iron overload, in contrast to hepcidin.	Iron	137-141	erythroferrone	Homo sapiens	5-9
31834456-8	2020	In conclusion, we suggest that using the ERFE gene expression, combined with serum hepcidin estimation, can substantiate the role of estimated TS% as a promising tool in screening for iron overload in beta-TM patients.	Iron	184-188	erythroferrone	Homo sapiens	41-45
7262818-9	1981	delta 6-desaturase appeared as a single polypeptide of 66,000 daltons containing 49% nonpolar amino acid residues and one atom of non-heme iron.	Iron	139-143	fatty acid desaturase 2	Rattus norvegicus	0-18
31819181-0	2020	Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention.	Iron	124-128	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	16-54
31819181-1	2020	BACKGROUND: 3-Hydroxybutyrate dehydrogenase type 2 (BDH2) is known to catalyse a rate-limiting step in the biogenesis of the mammalian siderophore and regulate intracellular iron metabolism.	Iron	174-178	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	12-50
7262818-13	1981	The delta 6-desaturase activity was inhibited by iron chelators, cyanine and p-chloromercuriphenyl sulfonate.	Iron	49-53	fatty acid desaturase 2	Rattus norvegicus	4-22
31819181-1	2020	BACKGROUND: 3-Hydroxybutyrate dehydrogenase type 2 (BDH2) is known to catalyse a rate-limiting step in the biogenesis of the mammalian siderophore and regulate intracellular iron metabolism.	Iron	174-178	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	52-56
6251068-3	1980	In the initial, second order step the two fragments combine to form an intermediate complex which exhibits tryptophan 59 fluorescence quenching similar to native cytochrome c, but which has not yet achieved the native ligation state of the heme iron.	Iron	245-249	cytochrome c, somatic	Equus caballus	162-174
31819181-10	2020	In addition, a higher level of BDH2 decreased the growth and metastasis of NPC cells via reducing intracellular iron level.	Iron	112-116	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	31-35
7458663-0	1980	[The influence of ceruloplasmin injections on the Cu- and Fe-metabolism of piglets].	Iron	58-60	ceruloplasmin	Homo sapiens	18-31
7458663-1	1980	In two experiments with a total of 56 piglets the influence of intravenous injections of ceruloplasmin (CP) on the 2nd and 4th day of their lives on criteria of the Cu- and Fe-metabolism was investigated.	Iron	173-175	ceruloplasmin	Homo sapiens	89-102
7458663-1	1980	In two experiments with a total of 56 piglets the influence of intravenous injections of ceruloplasmin (CP) on the 2nd and 4th day of their lives on criteria of the Cu- and Fe-metabolism was investigated.	Iron	173-175	ceruloplasmin	Homo sapiens	104-106
6248529-2	1980	The conformation of cytochrome c in solution is believed to change depending on the oxidation-reduction state of the heme iron, since ferri- and ferrocytochrome c exhibit several different physicochemical properties, but so far it is unknown if the conformational difference(s) is (are) confined to a particular part or domain of the molecule.	Iron	122-126	cytochrome c, somatic	Equus caballus	20-32
32114569-2	2020	Myoglobin is an iron and oxygen-binding protein that is freely filtered by the glomerulus.	Iron	16-20	myoglobin	Homo sapiens	0-9
6249590-7	1980	We conclude that the unprotonated form of imidazole inhibits iron deposition, possibly by binding to the active site of the apoferritin molecule.	Iron	61-65	ferritin heavy chain 1	Homo sapiens	124-135
31475901-3	2020	In the case of MCD, it was observed that IL-6 is overproduced from T-cells and macrophage which disturbs Hepcidin, a vital regulator of iron trafficking in macrophage.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	105-113
6772569-1	1980	Lactoferrin is an iron-binding protein that has been detected in secretions that bathe human mucosal tissues.	Iron	18-22	lactotransferrin	Mus musculus	0-11
32003680-5	2020	Hepcidin seems to play a role in iron accumulation in DIOS and NAFLD patients who show elevated serum hepcidin levels.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
32003680-5	2020	Hepcidin seems to play a role in iron accumulation in DIOS and NAFLD patients who show elevated serum hepcidin levels.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	102-110
7394833-4	1980	It was found that 48V was incorporated into lactoferrin, the milk protein which contains iron.	Iron	89-93	lactotransferrin	Bos taurus	44-55
31811823-12	2020	CONCLUSIONS: Synthesis and expression of hepcidin and Fpn in the ciliary epithelium suggests local regulation of iron transport from choroidal plexus in the ciliary body to the AH across the blood-aqueous barrier.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	41-49
31811823-13	2020	Expression of hepcidin and Fpn in CE, TM, and LE cells indicates additional regulation of iron exchange between the AH and cornea, TM, and lens, suggesting autonomous regulation of iron homeostasis in the anterior segment.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	14-22
31811823-13	2020	Expression of hepcidin and Fpn in CE, TM, and LE cells indicates additional regulation of iron exchange between the AH and cornea, TM, and lens, suggesting autonomous regulation of iron homeostasis in the anterior segment.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	14-22
42443-1	1979	Iron release from human, rabbit, rat and sheep transferrin, chicken conalbumin and human lactoferrin was measured by the change in absorbance of solutions of the iron-protein complexes or by the release of 59Fe from the protein conjugated to agarose.	Iron	0-4	transferrin (ovotransferrin)	Gallus gallus	68-78
31810825-0	2020	Regulation of hepcidin/iron-signalling pathway interactions by commensal bifidobateria plays an important role for the inhibition of metaflammation-related biomarkers.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	14-22
508633-1	1979	Erythrokinetic parameters were estimated in six patients suffering from congenital dyserythropoietic anaemia type II (CDA II) by means of a mathematical model of iron kinetics.	Iron	162-166	SEC23 homolog B, COPII coat complex component	Homo sapiens	118-124
33133674-5	2020	Here, we comment on the most recent findings addressing the interplay between adipocyte and ATM iron handling, and metabolic dysfunction.	Iron	96-100	ATM serine/threonine kinase	Homo sapiens	92-95
31520313-3	2020	Systemic iron homeostasis is centered around the regulation of iron absorption from duodenum and iron release from stores by hepcidin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	125-133
446656-0	1979	Direct evidence favouring the notion that erythropoietin alters iron transport across the isolated intestinal tract of the rat.	Iron	64-68	erythropoietin	Rattus norvegicus	42-56
214124-4	1978	Further measurements on laccase from the fungus Polyporus versicolor and human ceruloplasmin (iron(II):oxygen oxidoreductase, EC 1.16.3.1) are presented.	Iron	94-98	ceruloplasmin	Homo sapiens	79-92
32879588-7	2020	The principal pattern is a shift from a Neolithic iconic art which uses heavily encoded imagery, often schematic geometric motifs, to a Bronze/Iron Age narrative art, which increasingly involves imagery of identifiable people, animals and objects.	Iron	143-147	artemin	Homo sapiens	162-165
679425-4	1978	Since the only pharmacological property CO and metyrapone are thought to have in common at the concentrations employed is the ability to bind to the heme iron of cytochrome P-450, these results are consistent with the hypothesis that desaturation of this cytochrome leads to pulmonary vasoconstriction.	Iron	154-158	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	162-178
32818935-2	2020	The hormone hepcidin downregulates dietary iron absorption.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	12-20
32818935-3	2020	Hepcidin production increases with increased body iron status (reflected in serum ferritin levels).	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
32818935-13	2020	Hepcidin levels correlate with iron status in each group; however, this relationship is relatively dampened in infants fed breast milk.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
32818935-14	2020	We speculate that relatively lower infant hepcidin contributes to the superior efficiency of iron absorption from breast milk.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	42-50
904976-1	1977	The activity of heme synthetase (ferrochelatase), the enzyme(s) which catalyzes the formation of heme from iron and protoporphyrin IX, was studied in the various fractions of a cell-free reticulocyte system which synthesizes hemoglobin.	Iron	107-111	ferrochelatase, mitochondrial	Oryctolagus cuniculus	33-47
31825671-11	2020	Ret-He and Hypo-He can be used to assess iron supply for erythropoiesis in patients with IBD, to evaluate long-term (Hypo-He) and short-term (Ret-He) periods.	Iron	41-45	ret proto-oncogene	Homo sapiens	0-3
894189-0	1977	The ingestion and digestion of human lactoferrin by mouse peritoneal macrophages and the transfer of its iron into ferritin.	Iron	105-109	lactotransferrin	Mus musculus	37-48
31955851-0	2020	Iron Overload in Renal Transplant Patients: The Role of Hepcidin and Erythropoietin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	56-64
31955851-2	2020	We raised the hypothesis that post-transplant hypererythropoietinemia might induce reduction in serum hepcidin, favoring iron absorption.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	102-110
13072-12	1977	At extremes of pH, the horse and bakers" yeast iso-1 proteins display several high and low spin forms that are identified, showing that a variety of protein-derived ligands will coordinate to the heme iron including methionine and cysteine sulfur, histidine imidazole, and lysine epsilon-amine.	Iron	201-205	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	47-52
32253873-1	2020	Iron-refractory iron deficiency anemia (IRIDA) is an inherited iron metabolism disorder caused by mutations in TMPRSS6 gene encoding matriptase-2, which results in increased hepcidin synthesis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	174-182
189301-7	1977	We have calculated a volume change of --50 cm3/mol associated with the configurational change accompanying the reformation of the iron-methionine bond in cytochrome c at low pH.	Iron	130-134	cytochrome c, somatic	Equus caballus	154-166
31769769-2	2019	The results indicate that Pr2Ni2In and Nd2Ni2In compounds have a tetragonal Mo2FeB2-type structure belonging to the P4/mbm space group and undergo a second-order paramagnetic to ferromagnetic (PM to FM) transition at a Curie temperature (TC) of 7.5 and 10.5 K, respectively, whereas Dy2Ni2In and Ho2Ni2In compounds have an orthorhombic Mn2AlB2-type structure belonging to the space group Cmmm and possess a magnetic transition from PM to antiferromagnetic (AFM) at a Neel temperature TN of 19 and 10.5 K together with a first-order field induced metamagnetic transition, respectively.	Iron	76-83	solute carrier family 10 member 4	Homo sapiens	116-122
31949885-1	2019	Summary: The present investigation found that curculigoside (CUR) can prevent excess-iron-induced bone loss in mice and cells through antioxidation and inhibiting excess-iron-induced phosphorylation of the Akt-FoxO1 pathway.	Iron	170-174	forkhead box O1	Mus musculus	210-215
31949885-2	2019	CUR can attenuate the decreasing of cell viability, enhance autophagy, potentiate the antioxidant effect, and reduce apoptosis in MC3T3-E1 cells treated with excess iron through regulating the expression of FoxO1 target gene.	Iron	165-169	forkhead box O1	Mus musculus	207-212
183481-3	1976	Ceruloplasmin mobilizes iron into the plasma from iron storage cells in the liver.	Iron	24-28	ceruloplasmin	Homo sapiens	0-13
31704095-1	2019	Heme oxygenase-1 (HO-1) catalyzes heme degradation to generate biliverdin-IXalpha, carbon monoxide (CO), and iron.	Iron	109-113	heme oxygenase 1	Homo sapiens	0-16
31704095-1	2019	Heme oxygenase-1 (HO-1) catalyzes heme degradation to generate biliverdin-IXalpha, carbon monoxide (CO), and iron.	Iron	109-113	heme oxygenase 1	Homo sapiens	18-22
31676601-10	2019	These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs.	Iron	90-94	SRY (sex determining region Y)-box 10	Mus musculus	459-464
183481-3	1976	Ceruloplasmin mobilizes iron into the plasma from iron storage cells in the liver.	Iron	50-54	ceruloplasmin	Homo sapiens	0-13
812826-3	1975	Addition of the iron-binding protein conalbumin reduced or delayed the lethal effect of T1, but not T3, gonococci although growth of both colony types in the allantoic cavity of the embryo was inhibited by this protwin.	Iron	16-20	transferrin (ovotransferrin)	Gallus gallus	37-47
31808893-2	2019	For instance, the peptide hormone hepcidin is central to the regulation of iron metabolism.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	34-42
31808893-5	2019	Erythroferrone-induced hepcidin suppression in diseases of expanded hematopoiesis results in iron overload.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	23-31
31808893-6	2019	Conversely, diseases, such as iron refractory iron deficiency anemia and anemia of chronic inflammation, are characterized by aberrantly increased hepcidin, resulting in iron sequestration and decreased circulating iron and eventually leading to iron-restricted erythropoiesis.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	147-155
31808893-6	2019	Conversely, diseases, such as iron refractory iron deficiency anemia and anemia of chronic inflammation, are characterized by aberrantly increased hepcidin, resulting in iron sequestration and decreased circulating iron and eventually leading to iron-restricted erythropoiesis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	147-155
31808893-6	2019	Conversely, diseases, such as iron refractory iron deficiency anemia and anemia of chronic inflammation, are characterized by aberrantly increased hepcidin, resulting in iron sequestration and decreased circulating iron and eventually leading to iron-restricted erythropoiesis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	147-155
812826-4	1975	This effect can be attributed specifically to deprivation of iron since the iron-complexed form of conalbumin had no apparent influence on growth or virulence.	Iron	61-65	transferrin (ovotransferrin)	Gallus gallus	99-109
812826-4	1975	This effect can be attributed specifically to deprivation of iron since the iron-complexed form of conalbumin had no apparent influence on growth or virulence.	Iron	76-80	transferrin (ovotransferrin)	Gallus gallus	99-109
31560858-2	2019	Ceruloplasmin ferroxidase activity being considered essential for macrophage iron release, macrophage iron overload is expected, but it is not found in hepatic and splenic macrophages in humans.	Iron	77-81	ceruloplasmin	Homo sapiens	0-25
1125327-0	1975	Erythropoietin effects on iron metabolism in rat bone marrow cells.	Iron	26-30	erythropoietin	Rattus norvegicus	0-14
31373375-10	2019	RESULTS: In the hippocampus, APP/PS1-High Fe mice had significantly higher iron concentration (2.5-fold) and ferritin (2.0-fold) than APP/PS1-Ctrl mice (P < 0.001), and WT-High Fe mice had significantly higher ferritin (2.0-fold) than WT-Ctrl mice (P < 0.001).	Iron	75-79	presenilin 1	Mus musculus	33-36
4214890-4	1974	Lactoferrin extracted from leukocytes was able to bind the amount of iron corresponding to its theoretical iron-binding capacity.	Iron	69-73	lactotransferrin	Rattus norvegicus	0-11
31504675-3	2019	Iron overload is also quite common, usually being the result of genetic mutations which lead to inappropriate expression of the iron-regulatory hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	152-160
31504675-3	2019	Iron overload is also quite common, usually being the result of genetic mutations which lead to inappropriate expression of the iron-regulatory hormone hepcidin.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	152-160
4214890-4	1974	Lactoferrin extracted from leukocytes was able to bind the amount of iron corresponding to its theoretical iron-binding capacity.	Iron	107-111	lactotransferrin	Rattus norvegicus	0-11
4214890-6	1974	(b) Lactoferrin is Able to Remove the Iron from Transferrin.	Iron	38-42	lactotransferrin	Rattus norvegicus	4-15
4214890-7	1974	Significant exchange of iron from transferrin to lactoferrin was observed in vitro only at a pH below 7.0 or in the presence of a high concentration of citrate.	Iron	24-28	lactotransferrin	Rattus norvegicus	49-60
31209480-8	2019	Egret-Burke TaMATE1B also had higher concentrations of water-extractable P, Fe and Al in the rhizosphere, indicating the release of mineral-protected C. In addition, citrate ligand facilitated Fe and Al release from soil, with their concentrations rising with increasing ligand concentration and incubation time.	Iron	76-78	LOC101664696	Triticum aestivum	12-20
4214890-8	1974	However, the fast elimination of lactoferrin in vivo, when saturated with iron, might account for the observed transfer of iron to endogenous or administered apolactoferrin.	Iron	74-78	lactotransferrin	Rattus norvegicus	33-44
31209480-8	2019	Egret-Burke TaMATE1B also had higher concentrations of water-extractable P, Fe and Al in the rhizosphere, indicating the release of mineral-protected C. In addition, citrate ligand facilitated Fe and Al release from soil, with their concentrations rising with increasing ligand concentration and incubation time.	Iron	193-195	LOC101664696	Triticum aestivum	12-20
4214890-8	1974	However, the fast elimination of lactoferrin in vivo, when saturated with iron, might account for the observed transfer of iron to endogenous or administered apolactoferrin.	Iron	123-127	lactotransferrin	Rattus norvegicus	33-44
4830220-3	1974	The processing of erythrocyte iron by the reticuloendothelial cell has been characterized by kinetic measurements of blood radioactivity made after the intravenous injection of heat-damaged erythrocytes labeled with (59)Fe and of transferrin-bound (55)Fe.	Iron	30-34	inhibitor of carbonic anhydrase	Canis lupus familiaris	230-241
31771607-8	2019	The malaria pathway upregulates C-reactive protein and serum hepcidin, thereby reducing iron absorption.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	61-69
5075227-3	1972	Starting from apoferritin, or ferritin of low iron content, Fe(2+) and an oxidizing agent, the uptake of iron can be recorded spectrophotometrically.	Iron	105-109	ferritin heavy chain 1	Homo sapiens	14-25
31771607-15	2019	CONCLUSIONS: Following long-term iron supplementation, dual inflammatory pathways that mediate hepcidin expression and culminate in progesterone withdrawal may account for the reduction in gestational age observed in first pregnancies in this area of high malaria exposure.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	95-103
31775364-6	2019	Adding iron to high-Pi-treated VSMC, on days 7-11, decreased apoptotic cell number (17.3 +- 2.6 vs 11.6 +- 1.6; Annexin V; % positive cells; day 11; Pi vs Pi + Fe; p &lt; 0.05).	Iron	7-11	annexin A5	Homo sapiens	112-121
31775364-8	2019	Studying the prosurvival axis GAS6/AXL, we found that iron treatment on days 9-14 counteracted protein high-Pi-stimulated down-regulation and induced its de novo synthesis.	Iron	54-58	growth arrest specific 6	Homo sapiens	30-34
5075227-3	1972	Starting from apoferritin, or ferritin of low iron content, Fe(2+) and an oxidizing agent, the uptake of iron can be recorded spectrophotometrically.	Iron	46-50	ferritin heavy chain 1	Homo sapiens	14-25
31775364-8	2019	Studying the prosurvival axis GAS6/AXL, we found that iron treatment on days 9-14 counteracted protein high-Pi-stimulated down-regulation and induced its de novo synthesis.	Iron	54-58	AXL receptor tyrosine kinase	Homo sapiens	35-38
5075227-5	1972	The progress curves of iron uptake by apoferritin are sigmoidal; those for ferritins of low iron content are hyperbolic.	Iron	23-27	ferritin heavy chain 1	Homo sapiens	38-49
5456798-1	1970	Iron transport by everted duodenal sacs in vitro was studied in mice with sex-linked anemia (gene symbol sla) (an inherited iron deficiency anemia), in normal mice, and in normal mice on iron-deficient and iron supplemented diets.	Iron	0-4	src-like adaptor	Mus musculus	105-108
31871928-1	2019	The DMT1 gene encodes divalent metal transporter 1, a membrane iron transport protein.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	4-8
5456798-2	1970	Although the over-all mucosal uptake of iron was the same in sla and normal sacs, transport of iron to the inside of the sac was much decreased in sla.	Iron	40-44	src-like adaptor	Mus musculus	61-64
31736392-3	2021	Hepcidin an acute phase peptide hormone gets elevated in conditions of iron overload, inflammation, infections, and cytotoxicity.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
5456798-2	1970	Although the over-all mucosal uptake of iron was the same in sla and normal sacs, transport of iron to the inside of the sac was much decreased in sla.	Iron	95-99	src-like adaptor	Mus musculus	147-150
5456798-3	1970	The iron transport defect in sla was emphasized by the fact that genotypically normal mice on an iron-deficient diet demonstrated greatly increased iron transport.	Iron	4-8	src-like adaptor	Mus musculus	29-32
5456798-3	1970	The iron transport defect in sla was emphasized by the fact that genotypically normal mice on an iron-deficient diet demonstrated greatly increased iron transport.	Iron	97-101	src-like adaptor	Mus musculus	29-32
31610192-1	2019	Sirt3 enzyme and mitochondrial abnormality can be related to excess fatigue or muscular dysfunction in multiple sclerosis (MS).Ellagic acid (EA) has a mitochondrial protector, iron chelator, antioxidant, and axon regenerator in neurons.In this study the effect of EAon muscle dysfunction, its mitochondria, and Sirt3 enzyme incuprizone-induced model of MSwas examined.	Iron	176-180	sirtuin 3	Mus musculus	0-5
5446645-2	1970	In vivo incorporation of radioactive iron (divalent 59Fe) and (14C) lysine into cytochrome c of the honey bee].	Iron	37-41	cytochrome c	Apis mellifera	80-92
31668704-8	2019	The Bola2-deficient mice and the mice carrying the deletion showed early evidence of iron deficiency, including a mild decrease in hemoglobin, lower plasma iron, microcytosis, and an increased red blood cell zinc-protoporphyrin-to-heme ratio.	Iron	85-89	bolA-like 2 (E. coli)	Mus musculus	4-9
31693663-6	2019	Using a systems approach that combines GWAS, network-based candidate identification, and reverse genetic screen, we identified new genes that regulate root growth in -P-Fe: VIM1, FH6, and VDAC3.	Iron	169-171	Zinc finger (C3HC4-type RING finger) family protein	Arabidopsis thaliana	173-177
31723437-2	2019	Hepcidin is the master regulator of iron homeostasis and distribution.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
31723437-9	2019	Hepcidin correlates were in line with hepcidin as an indicator of iron stores.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	38-46
31400017-1	2019	The erythroferrone (ERFE) is the erythroid regulator of hepatic iron metabolism by suppressing the expression of hepcidin.	Iron	64-68	erythroferrone	Homo sapiens	20-24
31400017-1	2019	The erythroferrone (ERFE) is the erythroid regulator of hepatic iron metabolism by suppressing the expression of hepcidin.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	113-121
31400017-6	2019	We demonstrated that the ERFE-A260S variant leads to increased levels of ERFE, with subsequently marked impairment of iron regulation pathways at the hepatic level.	Iron	118-122	erythroferrone	Homo sapiens	25-29
31400017-6	2019	We demonstrated that the ERFE-A260S variant leads to increased levels of ERFE, with subsequently marked impairment of iron regulation pathways at the hepatic level.	Iron	118-122	erythroferrone	Homo sapiens	73-77
31400017-7	2019	Functional characterization of ERFE-A260S in the hepatic cell system demonstrated its modifier role in iron overload by impairing the BMP/SMAD pathway.	Iron	103-107	erythroferrone	Homo sapiens	31-35
31401526-7	2019	Moreover, significantly changed expression of TFRC, FTL and FTH1 hinted that dysfunction of iron uptake and storage is a major inducer of ferroptosis.	Iron	92-96	ferritin heavy chain 1	Homo sapiens	60-64
31279900-5	2019	RESULTS: HO1 and the endoplasmic reticulum (ER) stress marker grp78 were upregulated, together with changes in the expression of multiple iron metabolism-related genes, in post-mortem brain samples from patients with liver cirrhosis and HE.	Iron	138-142	heme oxygenase 1	Homo sapiens	9-12
31279900-7	2019	Upregulation of HO1 by NH4Cl triggered ER stress and was associated with elevated levels of free ferrous iron and expression changes in iron metabolism-related genes, which were largely abolished after knockdown or inhibition of GS, GFAT1/2, HO1 or iron chelation.	Iron	105-109	heme oxygenase 1	Homo sapiens	16-19
31279900-7	2019	Upregulation of HO1 by NH4Cl triggered ER stress and was associated with elevated levels of free ferrous iron and expression changes in iron metabolism-related genes, which were largely abolished after knockdown or inhibition of GS, GFAT1/2, HO1 or iron chelation.	Iron	136-140	heme oxygenase 1	Homo sapiens	16-19
31607468-2	2019	The iron-regulatory hormone hepcidin can signal when an individual is ready-and-safe to receive iron.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
31607468-3	2019	We tested whether a hepcidin-guided screen-and-treat approach to combat iron-deficiency anaemia could achieve equivalent efficacy to universal administration, but with lower exposure to iron.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	20-28
31439541-7	2019	Corroborating our findings from the murine models of iron deficiency anemia, primary human MEP exhibit decreased proliferation and Mk-biased commitment after knockdown of Transferrin Receptor 2, a putative iron sensor.	Iron	53-57	transferrin receptor 2	Homo sapiens	171-193
31662016-3	2021	Reticulocyte hemoglobin content (RET-He), a measure of iron deficiency, has not been well evaluated prior to discharge in premature infants.Objectives: Our objectives were to evaluate RET-He and its correlation with serum ferritin (SF), an index of iron stores, at 35-36 weeks postmenstrual age (PMA) in <=32 weeks gestational age (GA) infants.Methods: We performed a prospective nested study involving 24-32 weeks GA infants who were receiving 2 mg/kg/day oral elemental iron with full enteral feedings at 35-36 weeks PMA.	Iron	55-59	ret proto-oncogene	Homo sapiens	33-36
31662016-9	2021	RET-He increases with an increase in iron stores, suggesting that additional iron supplementation prior to discharge to very premature infants with borderline low RET-He may help prevent iron deficiency during early infancy.	Iron	37-41	ret proto-oncogene	Homo sapiens	0-3
31662016-9	2021	RET-He increases with an increase in iron stores, suggesting that additional iron supplementation prior to discharge to very premature infants with borderline low RET-He may help prevent iron deficiency during early infancy.	Iron	77-81	ret proto-oncogene	Homo sapiens	0-3
31662016-9	2021	RET-He increases with an increase in iron stores, suggesting that additional iron supplementation prior to discharge to very premature infants with borderline low RET-He may help prevent iron deficiency during early infancy.	Iron	77-81	ret proto-oncogene	Homo sapiens	163-166
31644557-0	2019	Iron is increased in the brains of ageing mice lacking the neurofilament light gene.	Iron	0-4	neurofilament, light polypeptide	Mus musculus	59-78
31644557-7	2019	The most substantial difference between genotypes was found in Fe in the older animals, where, across many regions examined, there was elevated Fe in the NFL knockout mice.	Iron	63-65	neurofilament, light polypeptide	Mus musculus	154-157
31550138-2	2019	For example, the critical nitrenoid intermediates that mediate Rh2-catalyzed C-H amination have eluded characterization for more than 40 years.	Iron	26-35	Rh associated glycoprotein	Homo sapiens	63-66
31623146-10	2019	ADO and RFA could be excellent sources of protein and bioavailable Fe, making it a sustainable, low-cost food source to prevent malnutrition in humans.	Iron	67-69	2-aminoethanethiol dioxygenase	Homo sapiens	0-3
31556436-1	2019	A newly prepared tetraphenylethylene-based (TPE-based) covalent organic polymer (COP) named COP-1 exhibits high selectivity for sensing Fe3+ and the limit of detection (LOD) for Fe3+ is 0.42 muM, which is lower than the reported metal-free porous polymers.	Iron	136-140	caspase recruitment domain family member 16	Homo sapiens	92-97
31556436-1	2019	A newly prepared tetraphenylethylene-based (TPE-based) covalent organic polymer (COP) named COP-1 exhibits high selectivity for sensing Fe3+ and the limit of detection (LOD) for Fe3+ is 0.42 muM, which is lower than the reported metal-free porous polymers.	Iron	178-182	caspase recruitment domain family member 16	Homo sapiens	92-97
31556436-3	2019	The COP-1 shows potential applications in biosensors of Fe3+ and preparation of WLEDs.	Iron	56-60	caspase recruitment domain family member 16	Homo sapiens	4-9
31597392-9	2019	The inverse association between selenoproteins and hepcidin concentration supports a potential role of hepcidin as a mediator between selenium and iron status and warrants further studies to better understand this relationship.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	103-111
31597263-1	2019	In our previous study, Deferoxamine (DFO) increased the iron concentration by upregulating the expression levels of TfR1 and DMT1 and exacerbated the migration of triple-negative breast cancer cells.	Iron	56-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	125-129
31172340-9	2019	Moreover, fractalkine-induced hepcidin production of microglia initiated ferroportin internalisation of SH-SY5Y cells, which contributed to iron accumulation of neurons.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	30-38
31418949-0	2019	G protein-coupled oestrogen receptor stimulation ameliorates iron- and ovariectomy-induced memory impairments through the cAMP/PKA/CREB signalling pathway.	Iron	61-65	G protein-coupled estrogen receptor 1	Rattus norvegicus	0-36
31418949-0	2019	G protein-coupled oestrogen receptor stimulation ameliorates iron- and ovariectomy-induced memory impairments through the cAMP/PKA/CREB signalling pathway.	Iron	61-65	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	127-130
31418949-0	2019	G protein-coupled oestrogen receptor stimulation ameliorates iron- and ovariectomy-induced memory impairments through the cAMP/PKA/CREB signalling pathway.	Iron	61-65	cAMP responsive element binding protein 1	Rattus norvegicus	131-135
31418949-9	2019	The selective GPER agonist G1, administered immediately after training, reversed both iron- and OVX-induced memory impairments.	Iron	86-90	G protein-coupled estrogen receptor 1	Rattus norvegicus	14-18
31368533-8	2019	The FE group displayed marked grouping of slow fibres, accumulation of very small myofibres, a severe reduction in type IIa/I size ratio, highly variable inter-subject accumulation of neural cell adhesion molecule (NCAM)-positive myofibres, and an accumulation of pyknotic nuclei, indicative of recurring cycles of denervation/reinnervation and persistent denervation.	Iron	4-6	neural cell adhesion molecule 1	Homo sapiens	184-213
31368533-8	2019	The FE group displayed marked grouping of slow fibres, accumulation of very small myofibres, a severe reduction in type IIa/I size ratio, highly variable inter-subject accumulation of neural cell adhesion molecule (NCAM)-positive myofibres, and an accumulation of pyknotic nuclei, indicative of recurring cycles of denervation/reinnervation and persistent denervation.	Iron	4-6	neural cell adhesion molecule 1	Homo sapiens	215-219
31058762-10	2019	CONCLUSIONS: Although exercise resulted in increased concentrations of IL-6 and hepcidin, iron was best absorbed in the morning after exercise, indicating there may be a transient mechanism during the acute postexercise window to promote iron absorption opposing the homeostatic regulation by serum hepcidin elevations.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	299-307
32523182-1	1970	Photoionization yield curves from onset to 600A, and ionization threshold values have been obtained for the ions Fe ( CO ) 5 +   , Fe ( CO ) 4 +   , Fe ( CO ) 3 +   , Fe ( CO ) 2 +   , Fe ( CO ) +   , Fe+ and CO+ from iron penta-carbonyl, and for Ni ( CO ) 4 +   , Ni ( CO ) 3 +   , Ni ( CO ) 2 +   , Ni ( CO ) +   , Ni+, and CO+ from nickel tetracarbonyl.	Iron	131-133	complement C4A (Rodgers blood group)	Homo sapiens	136-142
31465212-3	2019	To identify the controlling features of S-site oxygen uptake, related Ni(mu-EPhX)(mu-S"N2)Fe (E = S or Se, Fe = (eta5-C5H5)FeII(CO)) complexes were electronically tuned by the para-substituent on mu-EPhX (X = CF3, Cl, H, OMe, NMe2) and compared in aspects of communication between Ni and Fe.	Iron	90-92	epoxide hydrolase 1	Homo sapiens	76-80
31465212-4	2019	Both single and double O atom uptake at the chalcogens led to the conversion of the four-membered ring core, Ni(mu-EPhX)(mu-S"N2)Fe, to a five-membered ring Ni-O-E-Fe-S", where an O atom inserts between E and Ni.	Iron	129-131	epoxide hydrolase 1	Homo sapiens	115-119
31465212-5	2019	In the E = S, X = NMe2 case, the two-oxygen uptake complex was isolated and characterized as the sulfinato species with the second O of the O2SPh-NMe2 unit pointing out of the five-membered Ni-O-S-Fe-S" ring.	Iron	197-201	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	18-22
32523182-1	1970	Photoionization yield curves from onset to 600A, and ionization threshold values have been obtained for the ions Fe ( CO ) 5 +   , Fe ( CO ) 4 +   , Fe ( CO ) 3 +   , Fe ( CO ) 2 +   , Fe ( CO ) +   , Fe+ and CO+ from iron penta-carbonyl, and for Ni ( CO ) 4 +   , Ni ( CO ) 3 +   , Ni ( CO ) 2 +   , Ni ( CO ) +   , Ni+, and CO+ from nickel tetracarbonyl.	Iron	131-133	complement C4A (Rodgers blood group)	Homo sapiens	136-142
5360468-0	1969	Mobilization of liver iron by ferroxidase (ceruloplasmin).	Iron	22-26	ceruloplasmin	Homo sapiens	43-56
31482160-0	2019	Expression of concern: Ligand discrimination of myoglobin in solution: an iron L-edge X-ray absorption study of the active centre.	Iron	74-78	myoglobin	Homo sapiens	48-57
31482160-1	2019	Expression of concern for "Ligand discrimination of myoglobin in solution: an iron L-edge X-ray absorption study of the active centre" by Kathrin M. Lange et al., Chem.	Iron	78-82	myoglobin	Homo sapiens	52-61
4899010-4	1969	The amount of available iron in serum is determined by the ratio between iron-saturated and iron-free transferrin; a low value for the ratio is associated with tuberculostasis (e.g., human serum, 0.4), whereas a high value is associated with the growth-supporting quality (e.g., guinea pig serum, 5.6).	Iron	24-28	inhibitor of carbonic anhydrase	Cavia porcellus	102-113
31287589-0	2019	Coordination Chemistry of P4 S3 and P4 Se3 towards the Iron Fragments [Fe(Cp)(CO)2 ]+ and [Fe(Cp)(PPh3 )(CO)].	Iron	55-59	protein phosphatase 4 catalytic subunit	Homo sapiens	98-102
31340089-9	2019	The mean reduction from baseline in the hepcidin level (associated with greater iron availability) was 56.14+-63.40 ng per milliliter in the roxadustat group and 15.10+-48.06 ng per milliliter in the placebo group.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	40-48
4910296-0	1969	Ceruloplasmin, a link between copper and iron metabolism.	Iron	41-45	ceruloplasmin	Homo sapiens	0-13
31433635-3	2019	In this study, inoculation with Enterobacter asburiae NC16 reduced transpiration rates and the expression of some iron (Fe) uptake-related genes including ZmFer, ZmYS1, ZmZIP, and ZmNAS2 in maize (Zea mays) plants, which contributed to mitigation of Cd toxicity.	Iron	114-118	iron-phytosiderophore transporter yellow stripe 1	Zea mays	162-167
17773234-1	1968	A reflection minimum at 1 micron, reported for Moon and for Mars, indicates olivine or iron- and calcium-bearing clinopyroxene, or both-major constituents of many basaltic rocks.	Iron	87-91	methionyl-tRNA synthetase 1	Homo sapiens	60-64
31433635-3	2019	In this study, inoculation with Enterobacter asburiae NC16 reduced transpiration rates and the expression of some iron (Fe) uptake-related genes including ZmFer, ZmYS1, ZmZIP, and ZmNAS2 in maize (Zea mays) plants, which contributed to mitigation of Cd toxicity.	Iron	120-122	iron-phytosiderophore transporter yellow stripe 1	Zea mays	162-167
4967130-0	1968	Role of iron in the oxidase activity of ceruloplasmin.	Iron	8-12	ceruloplasmin	Homo sapiens	40-53
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	estrogen related receptor gamma	Sus scrofa	256-261
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	PPARG coactivator 1 alpha	Sus scrofa	269-277
5635634-0	1968	Changes in iron metabolism in natives of 13,000 ft. brought down to sea level.	Iron	11-15	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	68-71
31611207-0	2019	Serum Hepcidin to Prohepcidin Ratio in Children with Iron Deficiency Anemia.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	6-14
31611207-7	2019	RESULTS: Hepcidin was positively correlated with hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, iron, transferrin saturation, and ferritin, and negatively correlated with total iron binding capacity and transferrin.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	9-17
31611207-7	2019	RESULTS: Hepcidin was positively correlated with hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, iron, transferrin saturation, and ferritin, and negatively correlated with total iron binding capacity and transferrin.	Iron	239-243	hepcidin antimicrobial peptide	Homo sapiens	9-17
31082798-2	2019	However, the relationship between ERFE and abnormal iron metabolism in MDS is unclear.	Iron	52-56	erythroferrone	Homo sapiens	34-38
6011202-0	1966	[Synthesis of apoferritin-iron complex in a test tube and its properties].	Iron	26-30	ferritin heavy chain 1	Homo sapiens	14-25
31233777-3	2019	The direct structural links between iron and alpha-synuclein suggest that structural reorganization provokes alpha-synuclein conformational change.	Iron	36-40	synuclein alpha	Homo sapiens	45-60
31233777-3	2019	The direct structural links between iron and alpha-synuclein suggest that structural reorganization provokes alpha-synuclein conformational change.	Iron	36-40	synuclein alpha	Homo sapiens	109-124
31233777-4	2019	Iron post-transcriptionally regulates alpha-synuclein synthesis in the presence of iron-responsive element.	Iron	0-4	synuclein alpha	Homo sapiens	38-53
31233777-4	2019	Iron post-transcriptionally regulates alpha-synuclein synthesis in the presence of iron-responsive element.	Iron	83-87	synuclein alpha	Homo sapiens	38-53
31233777-5	2019	Increased oxidative/nitrative stress induced by iron is believed to be involved in the post-translational modulation of alpha-synuclein.	Iron	48-52	synuclein alpha	Homo sapiens	120-135
5885853-0	1965	Mechanism of iron stimulation of the enzymatic activity of ceruloplasmin.	Iron	13-17	ceruloplasmin	Homo sapiens	59-72
31233777-6	2019	Iron modulates proteolytic pathways and therefore participates in the regulation of alpha-synuclein levels.	Iron	0-4	synuclein alpha	Homo sapiens	84-99
31233777-8	2019	Finally, alpha-synuclein might regulate iron metabolism through its ferrireductase activity.	Iron	40-44	synuclein alpha	Homo sapiens	9-24
31233777-9	2019	A prominent role of alpha-synuclein in iron homeostasis is involved in the uptake of transferrin-Fe.	Iron	39-43	synuclein alpha	Homo sapiens	20-35
31233777-9	2019	A prominent role of alpha-synuclein in iron homeostasis is involved in the uptake of transferrin-Fe.	Iron	97-99	synuclein alpha	Homo sapiens	20-35
30765471-4	2019	In erythroid cells, loss of ABCB7 altered cellular iron distribution and caused mitochondrial iron overload due to activation of iron regulatory proteins 1 and 2 in the cytosol and to upregulation of the mitochondrial iron importer, mitoferrin-1.	Iron	51-55	ATP binding cassette subfamily B member 7	Homo sapiens	28-33
30765471-4	2019	In erythroid cells, loss of ABCB7 altered cellular iron distribution and caused mitochondrial iron overload due to activation of iron regulatory proteins 1 and 2 in the cytosol and to upregulation of the mitochondrial iron importer, mitoferrin-1.	Iron	94-98	ATP binding cassette subfamily B member 7	Homo sapiens	28-33
30765471-4	2019	In erythroid cells, loss of ABCB7 altered cellular iron distribution and caused mitochondrial iron overload due to activation of iron regulatory proteins 1 and 2 in the cytosol and to upregulation of the mitochondrial iron importer, mitoferrin-1.	Iron	94-98	ATP binding cassette subfamily B member 7	Homo sapiens	28-33
14336439-0	1965	FAILURE OF ACTINOMYCIN D TO PREVENT INDUCTION OF LIVER APOFERRITIN AFTER IRON ADMINISTRATION.	Iron	73-77	ferritin heavy chain 1	Homo sapiens	55-66
30765471-6	2019	In ABCB7-depleted cells, defective heme biosynthesis resulted from translational repression of ALAS2 by iron regulatory proteins and from decreased stability of the terminal enzyme ferrochelatase.	Iron	104-108	ATP binding cassette subfamily B member 7	Homo sapiens	3-8
30765471-9	2019	Our studies not only underscore the importance of ABCB7 for mitochondrial Fe-S biogenesis and iron homeostasis, but also provide the biochemical characterization of a multiprotein complex required for heme biosynthesis.	Iron	94-98	ATP binding cassette subfamily B member 7	Homo sapiens	50-55
14174292-0	1964	[PATHOLOGICAL CHANGES IN THE MUCOSA OF THE UPPER RESPIRATORY TRACT AND LARYNX IN GRAY CAST IRON FOUNDRY WORKERS, THEIR PREVENTION AND THERAPY].	Iron	91-95	calpastatin	Homo sapiens	86-90
31162576-11	2019	In Study 2, hippocampal Glut1 (+14%) and Hif1alpha (+147%) expression was upregulated in the iron-deficient DNTfR1-/- mice, but not in the iron-replete DNTfR1-/- mice, relative to the WT mice (P &lt; 0.05, all).	Iron	93-97	hypoxia inducible factor 1, alpha subunit	Mus musculus	41-50
14217510-0	1964	"FREE" APOFERRITIN AND APOFERRITIN OBTAINED BY REDUCTION OF IRON-CONTAINING FERRITIN.	Iron	60-64	ferritin heavy chain 1	Homo sapiens	7-18
31270208-0	2019	Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms.	Iron	70-74	sterol regulatory element binding transcription factor 1	Mus musculus	10-18
14217510-0	1964	"FREE" APOFERRITIN AND APOFERRITIN OBTAINED BY REDUCTION OF IRON-CONTAINING FERRITIN.	Iron	60-64	ferritin heavy chain 1	Homo sapiens	23-34
31270208-0	2019	Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms.	Iron	134-138	sterol regulatory element binding transcription factor 1	Mus musculus	10-18
14161230-0	1964	EFFECT OF AN ERYTHROPOIETIN PREPARATION ON UPTAKE OF IRON-59 BY TIBIAE OF NEW-BORN RATS.	Iron	53-57	erythropoietin	Rattus norvegicus	13-27
31423010-6	2019	The cellular iron concentration regulated the expression of the iron-regulatory protein (IRP) via the 5"-untranslated region of IRP messenger RNA and modulated the post-transcriptional stability of FPN1.	Iron	13-17	solute carrier family 40 member 1	Homo sapiens	198-202
31423010-8	2019	Nrf2-mediated FPN1 downregulation promoted intracellular iron accumulation and reactive oxygen species.	Iron	57-61	solute carrier family 40 member 1	Homo sapiens	14-18
17795255-0	1946	Protein Apoferritin and Ferritin in Iron Feeding and Absorption.	Iron	36-40	ferritin heavy chain 1	Homo sapiens	8-19
31666842-1	2019	BACKGROUND: Hepcidin, a small peptide hormone, is established as the main regulator of iron homeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	12-20
31666842-14	2019	Knowing that hepcidin in serum has a dynamic and multi-factorial regulation, individual evaluation of serum hepcidin and follow up, e.g. every 6 months could be valuable, and future therapeutic hepcidin agonists could be helpful in management of iron burden in such patient.	Iron	246-250	hepcidin antimicrobial peptide	Homo sapiens	13-21
31395877-4	2019	By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters.	Iron	195-197	ferredoxin 2	Homo sapiens	115-119
21010560-0	1946	Protein apoferritin and ferritin in iron feeding and absorption.	Iron	36-40	ferritin heavy chain 1	Homo sapiens	8-19
31088840-2	2019	Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor"s responses to changes in oxygen, iron, nutrient, or energy levels.	Iron	144-148	folliculin	Homo sapiens	62-66
33689857-2	2021	ABCB7 also plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins, and mutations can cause a series of mitochondrial defects.	Iron	76-78	ATP binding cassette subfamily B member 7	Homo sapiens	0-5
31447555-5	2019	NAC can effectively mitigate iron-induced oxidative injury of cardiomyocytes, evidenced by reduced production of MDA, 8-iso-PGF2alpha, and 8-OHDG and maintained concentrations of SOD, CAT, GSH-Px, and GSH in ELISA and biochemical tests; downregulated expression of CHOP, GRP78, p62, and LC3-II proteins in Western Blot, and less cardiomyocytes apoptosis in flow cytometric analysis.	Iron	29-33	DNA-damage inducible transcript 3	Rattus norvegicus	265-269
33507490-2	2021	Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintaining iron homeostasis.	Iron	184-188	ferritin heavy chain 1	Homo sapiens	80-100
30536543-8	2019	Based on a few experimental studies, the combination of iron chelators with some anti-oxidants, including NAC, vitamin C, and acetaminophen, can lead to improved cardiac protection.	Iron	56-60	synuclein alpha	Homo sapiens	106-109
31431773-0	2019	Hepcidin: A key regulator of iron.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
31431773-4	2019	Inflammation or iron overload greatly stimulate production of hepcidin by hepatocytes.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	62-70
34047563-7	2021	The analysis of data reveals that photoinduced electron transfer is responsible for fluorescence quenching of QDs in the presence of first-row TM ions and destruction/removal of trap/defect states in the case of Cd2+ causes the FE.	Iron	228-230	CD2 molecule	Homo sapiens	212-215
31431773-5	2019	Recent evidences have revealed that mutations in the human haemochromatosis (HFE) gene lead to deficiency of hepcidin which is responsible for iron overload and contributing to haemochromatosis.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	109-117
31431773-9	2019	By understanding the mechanism of hepcidin and its pathological roles in blood and iron diseases could lead to new therapies.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	34-42
34043061-1	2021	Pathogenic variants in the WDR45 (OMIM: 300,526) gene on chromosome Xp11 are the genetic cause of a rare neurological disorder characterized by increased iron deposition in the basal ganglia.	Iron	154-158	modified polytropic murine leukemia virus 23	Mus musculus	68-72
30239062-1	2019	BACKGROUND/AIMS: Hepcidin-25 (HEP-25) and erythroferrone (ERFE) are key regulators of iron homeostasis.	Iron	86-90	erythroferrone	Homo sapiens	42-56
30239062-1	2019	BACKGROUND/AIMS: Hepcidin-25 (HEP-25) and erythroferrone (ERFE) are key regulators of iron homeostasis.	Iron	86-90	erythroferrone	Homo sapiens	58-62
34011924-6	2021	Mechanically, MYCN expression reprograms the cellular iron metabolism by upregulating the expression of TFRC, which encodes transferrin receptor 1 as a key iron transporter on the cell membrane.	Iron	54-58	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	14-18
31332290-1	2019	p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2).	Iron	31-35	transformation related protein 53, pseudogene	Mus musculus	0-3
31332290-1	2019	p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2).	Iron	82-86	transformation related protein 53, pseudogene	Mus musculus	0-3
31332290-2	2019	Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism.	Iron	59-63	transformation related protein 53, pseudogene	Mus musculus	15-18
31332290-2	2019	Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism.	Iron	59-63	transformation related protein 53, pseudogene	Mus musculus	109-112
31332290-2	2019	Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism.	Iron	156-160	transformation related protein 53, pseudogene	Mus musculus	15-18
31332290-2	2019	Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism.	Iron	156-160	transformation related protein 53, pseudogene	Mus musculus	109-112
31332290-3	2019	In this study, we found that FDXR deficiency decreased mutant p53 expression along with altered iron metabolism in p53R270H/- MEFs and cancer cells carrying mutant p53.	Iron	96-100	transformation related protein 53, pseudogene	Mus musculus	115-118
34011924-6	2021	Mechanically, MYCN expression reprograms the cellular iron metabolism by upregulating the expression of TFRC, which encodes transferrin receptor 1 as a key iron transporter on the cell membrane.	Iron	156-160	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	14-18
31229404-1	2019	The iron-sensing protein FBXL5 is the substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradation of iron regulatory proteins (IRPs).	Iron	4-8	S-phase kinase associated protein 1	Homo sapiens	62-66
34015752-4	2021	Calcium was found to affect directly IRT1-mediated iron import through the lipid-binding protein EHB1 and to trigger a CBL-CIPK-mediated signaling influencing the activity of the key iron-acquisition transcription factor FIT.	Iron	51-55	allograft inflammatory factor 1	Homo sapiens	37-41
33993583-2	2022	The liver hormone hepcidin is the master regulator of systemic iron balance by controlling the degradation and function of the sole known mammalian iron exporter ferroportin.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	18-26
31396090-3	2019	Heme oxygenase (HO) -1 can catabolize free heme into carbon monoxide (CO), ferrous iron, and biliverdin (BV)/bilirubin (BR).	Iron	83-87	heme oxygenase 1	Homo sapiens	0-22
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	37-41	fatty acid binding protein 4, adipocyte	Mus musculus	68-73
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	37-41	ceruloplasmin	Mus musculus	108-121
33993583-2	2022	The liver hormone hepcidin is the master regulator of systemic iron balance by controlling the degradation and function of the sole known mammalian iron exporter ferroportin.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	18-26
33993583-3	2022	Liver hepcidin expression is coordinately regulated by several signals that indicate the need for more or less iron, including plasma and tissue iron levels, inflammation, and erythropoietic drive.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	6-14
33993583-3	2022	Liver hepcidin expression is coordinately regulated by several signals that indicate the need for more or less iron, including plasma and tissue iron levels, inflammation, and erythropoietic drive.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	6-14
31316058-4	2019	Our in vivo and in vitro models show labile iron accumulation and enhanced lipid peroxidation with concomitant non-apoptotic cell death during cigarette smoke (CS) exposure, which are negatively regulated by GPx4 activity.	Iron	44-48	glutathione peroxidase 4	Mus musculus	208-212
33993583-5	2022	Genetic disorders of iron overload and iron deficiency have identified several hepatocyte membrane proteins that play a critical role in mediating the BMP-SMAD and hepcidin regulatory response to iron.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	164-172
33993583-5	2022	Genetic disorders of iron overload and iron deficiency have identified several hepatocyte membrane proteins that play a critical role in mediating the BMP-SMAD and hepcidin regulatory response to iron.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	164-172
31296897-0	2019	ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients.	Iron	66-70	FEZ family zinc finger 2	Homo sapiens	0-3
31296897-4	2019	In this study, we have used time of flight secondary ion mass spectrometry (ToF-SIMS) to visualize and relatively quantify iron accumulation in lung tissue sections of healthy donors versus severe COPD patients.	Iron	123-127	FEZ family zinc finger 2	Homo sapiens	76-79
33989290-0	2021	Iron activates microglia and directly stimulates indoleamine-2,3-dioxygenase activity in the N171-82Q mouse model of Huntington"s disease.	Iron	0-4	indoleamine 2,3-dioxygenase 1	Mus musculus	49-76
31477260-4	2019	Hepcidin, a 25 amino acid peptide produced by the hepatocytes, has emerged as the key regulator of uptake and release of iron in the tissues to maintain a steady supply of iron to erythron and other tissues while avoiding higher levels of iron that could be detrimental to the organs.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	0-8
31477260-4	2019	Hepcidin, a 25 amino acid peptide produced by the hepatocytes, has emerged as the key regulator of uptake and release of iron in the tissues to maintain a steady supply of iron to erythron and other tissues while avoiding higher levels of iron that could be detrimental to the organs.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	0-8
31477260-5	2019	Hepcidin itself is regulated by the supply of iron, the need for erythropoiesis, and the state of inflammation.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
33989290-9	2021	We further demonstrate that iron activates IDO, both in brain lysates and purified recombinant protein (EC50 = 1.24 nM).	Iron	28-32	indoleamine 2,3-dioxygenase 1	Mus musculus	43-46
31477260-6	2019	Alterations in hepcidin levels are associated with restricted erythropoiesis, anemia, and iron overload.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	15-23
33989290-11	2021	Neonatal iron supplementation further promoted IDO activity in cerebral cortex, altered KP metabolite profiles, and promoted HD neurodegeneration as measured by brain weights and striatal volumes.	Iron	9-13	indoleamine 2,3-dioxygenase 1	Mus musculus	47-50
33989290-12	2021	Our results demonstrate that dietary iron is an important activator of microglia and the KP pathway in this HD model, and that this occurs in part through a direct effect on IDO.	Iron	37-41	indoleamine 2,3-dioxygenase 1	Mus musculus	174-177
33982118-2	2021	Iron homeostasis is influenced by 3 regulatory hormones: erythropoietin (EPO), hepcidin, and erythroferrone (ERFE).	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	79-87
31132316-6	2019	Accordingly, upon treatment with 50 muM iron, these chondrocytes were found to preferentially differentiate toward hypertrophy with increased expression of collagen I and transferrin and downregulation of SRY (sex-determining region Y)-box containing gene 9 (Sox9).	Iron	40-44	sex determining region of Chr Y	Mus musculus	205-208
33982118-2	2021	Iron homeostasis is influenced by 3 regulatory hormones: erythropoietin (EPO), hepcidin, and erythroferrone (ERFE).	Iron	0-4	erythroferrone	Homo sapiens	109-113
33982118-3	2021	To date, normative data on ERFE across pregnancy and its relations to other hormones and iron status indicators are limited.	Iron	89-93	erythroferrone	Homo sapiens	27-31
33942214-6	2021	TP53 (also known as p53) was verified as a target of miR-122-5p by using dual luciferase reporter assay, and restoration of TP53 attenuated the effects of miR-122-5p on ferroptotic marker proteins expression, iron ion concentration and lipid ROS levels, as well as solute carrier family seven member 11 (SLC7A11) mRNA expression.	Iron	209-213	transformation related protein 53	Mus musculus	0-4
33942214-6	2021	TP53 (also known as p53) was verified as a target of miR-122-5p by using dual luciferase reporter assay, and restoration of TP53 attenuated the effects of miR-122-5p on ferroptotic marker proteins expression, iron ion concentration and lipid ROS levels, as well as solute carrier family seven member 11 (SLC7A11) mRNA expression.	Iron	209-213	transformation related protein 53	Mus musculus	20-23
33942214-6	2021	TP53 (also known as p53) was verified as a target of miR-122-5p by using dual luciferase reporter assay, and restoration of TP53 attenuated the effects of miR-122-5p on ferroptotic marker proteins expression, iron ion concentration and lipid ROS levels, as well as solute carrier family seven member 11 (SLC7A11) mRNA expression.	Iron	209-213	transformation related protein 53	Mus musculus	124-128
33949973-0	2021	Crystallographic analysis and phasing of iron-assimilating protein 1 (FEA1) from Chlamydomonas reinhardtii.	Iron	41-45	uncharacterized protein	Chlamydomonas reinhardtii	70-74
33949973-2	2021	In Chlamydomonas reinhardtii, iron levels are strictly controlled by proteins such as iron-assimilating protein 1 (FEA1).	Iron	30-34	uncharacterized protein	Chlamydomonas reinhardtii	115-119
33949973-2	2021	In Chlamydomonas reinhardtii, iron levels are strictly controlled by proteins such as iron-assimilating protein 1 (FEA1).	Iron	86-90	uncharacterized protein	Chlamydomonas reinhardtii	115-119
33949973-8	2021	This study will lead to further structural studies of FEA1 to understand its function and its links to the iron-assimilation pathway.	Iron	107-111	uncharacterized protein	Chlamydomonas reinhardtii	54-58
33041329-0	2021	Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.	Iron	76-80	synuclein alpha	Homo sapiens	12-27
33398092-4	2021	Here, we report that ferroportin1 (Fpn), the only identified mammalian nonheme iron exporter, was downregulated in the brains of APPswe/PS1dE9 mice as an Alzheimer"s mouse model and Alzheimer"s patients.	Iron	79-83	solute carrier family 40 member 1	Homo sapiens	21-33
33398092-4	2021	Here, we report that ferroportin1 (Fpn), the only identified mammalian nonheme iron exporter, was downregulated in the brains of APPswe/PS1dE9 mice as an Alzheimer"s mouse model and Alzheimer"s patients.	Iron	79-83	solute carrier family 40 member 1	Homo sapiens	35-38
34014775-9	2021	Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha.	Iron	8-10	interleukin 1 alpha	Homo sapiens	86-94
34007416-7	2021	In some pathological circumstances, either genetic or acquired, hepcidin increases, limiting the absorption in the gut, remobilization, and recycling of iron, thereby reducing iron plasma levels.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	64-72
34007416-7	2021	In some pathological circumstances, either genetic or acquired, hepcidin increases, limiting the absorption in the gut, remobilization, and recycling of iron, thereby reducing iron plasma levels.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	64-72
34007416-8	2021	Indeed, conditions with high hepcidin levels are often under-recognized as iron refractory, leading to inappropriate and unsuccessful treatments.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	29-37
34007416-9	2021	This review provides an overview of the iron refractory anemia underlying conditions, from gastrointestinal pathologies to hepcidin dysregulation and iatrogenic or provoked conditions, and the specific diagnostic and treatment approach.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	123-131
33835366-2	2021	Iron-mediated hepcidin synthesis is triggered via the BMP/SMAD pathway.	Iron	0-4	SMAD family member 1	Mus musculus	58-62
33464620-7	2021	Either Cu supplement or overexpression of COPT2 or FRO4 improves the growth of fit-2 under Fe deficiency conditions.	Iron	91-93	ferric reduction oxidase 4	Arabidopsis thaliana	51-55
33464620-9	2021	This work through the link between bHLH Ib/FIT and COPT2/FRO4/FRO5 under Fe deficiency conditions establishes a new relationship between Cu and Fe homeostasis.	Iron	73-75	ferric reduction oxidase 4	Arabidopsis thaliana	57-61
33914705-0	2021	HIF-2alpha activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.	Iron	100-104	endothelial PAS domain protein 1	Mus musculus	0-10
33914705-7	2021	Our work demonstrates that HIF-2alpha integrates two independent forms of cell death via regulation of cellular iron and oxidation.	Iron	112-116	endothelial PAS domain protein 1	Mus musculus	27-37
33914705-8	2021	First, activation of HIF-2alpha upreguated lipid and iron regulatory genes in colon cancer cells and colon tumors in mice and led to a ferroptosis-susceptible cell state.	Iron	53-57	endothelial PAS domain protein 1	Mus musculus	21-31
33914705-9	2021	Secondly, via an iron dependent, lipid peroxidation-independent pathway, HIF-2alpha activation potentiated ROS, via irreversible cysteine oxidation and enhanced cell death.	Iron	17-21	endothelial PAS domain protein 1	Mus musculus	73-83
33856229-0	2021	Pioglitazone Inhibits Metal Cluster Transfer of mitoNEET by Stabilizing the Labile Fe-N Bond Revealed at Single-Bond Level.	Iron	83-85	CDGSH iron sulfur domain 1	Homo sapiens	48-56
33895185-3	2021	Hepcidin plays an important role in regulating homeostasis between circulating iron and stored iron in the cells as well as the absorption of dietary iron in the intestine.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	0-8
33895185-3	2021	Hepcidin plays an important role in regulating homeostasis between circulating iron and stored iron in the cells as well as the absorption of dietary iron in the intestine.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	0-8
33895185-3	2021	Hepcidin plays an important role in regulating homeostasis between circulating iron and stored iron in the cells as well as the absorption of dietary iron in the intestine.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	0-8
33895185-4	2021	Inflammatory disorders restrict iron absorption from food due to increased circulating levels of hepcidin.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	97-105
33895185-5	2021	Increased production of hepcidin causes ubiquitination of ferroportin (FPN) leading to its degradation, thereby retaining iron in the spleen, duodenal enterocytes, macrophages, and hepatocytes.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	24-32
33895185-11	2021	Hepcidin modulation with siRNAs, antibodies, chemical compounds, and plant extracts provides new insights for developing advanced therapeutics for iron-related disorders.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	0-8
33895185-12	2021	Hepcidin antagonist"s treatment has a high potential to improve iron status in patients with iron disorders, but their clinical success needs further recognition along with the identification and application of new therapeutic approaches.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
33876884-7	2021	Fe-scaffold was found to promote the cell adhesion compared with Uncoated-scaffold, including increasing the adhered cell number, promoting cell spreading and upregulating the expression levels of adhesion-related genes integrin alpha1 and beta1 and their downstream signaling molecules FAK and ERK1/2 (p < 0.05).	Iron	0-2	integrin subunit alpha 1	Rattus norvegicus	220-235
30946902-1	2019	Transferrin is a highly conserved multifunctional protein involved in iron metabolism, oxidative stress and immune response.	Iron	70-74	transferrin	Bombyx mori	0-11
33876884-7	2021	Fe-scaffold was found to promote the cell adhesion compared with Uncoated-scaffold, including increasing the adhered cell number, promoting cell spreading and upregulating the expression levels of adhesion-related genes integrin alpha1 and beta1 and their downstream signaling molecules FAK and ERK1/2 (p < 0.05).	Iron	0-2	protein tyrosine kinase 2	Rattus norvegicus	287-290
31267712-2	2019	Ferroptosis is a form of non-apoptotic cell death characterized by the iron-dependent overproduction of lipid hydroperoxides, which can be inhibited by the antioxidant activity of the solute carrier family member 11 (SLC7A11/xCT), a component of the cystine/glutamate antiporter.	Iron	71-75	solute carrier family 7 member 11	Homo sapiens	217-224
31267712-2	2019	Ferroptosis is a form of non-apoptotic cell death characterized by the iron-dependent overproduction of lipid hydroperoxides, which can be inhibited by the antioxidant activity of the solute carrier family member 11 (SLC7A11/xCT), a component of the cystine/glutamate antiporter.	Iron	71-75	solute carrier family 7 member 11	Homo sapiens	225-228
33610598-4	2021	Anti-hepcidin effect of heparin-iron was detected in HepG2 cell and LPS induced acute inflammation mice by qRT-PCR and ELISA.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	5-13
33855731-0	2021	Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin.	Iron	33-37	adiponectin, C1Q and collagen domain containing	Mus musculus	85-96
31104243-9	2019	The increased concentration of urinary Cd, Cu, Fe, and Pb quartiles was found significant correlated with PTC risk.	Iron	47-49	coiled-coil domain containing 6	Homo sapiens	106-109
31104243-12	2019	Our study suggested that PTC was positively associated with urinary levels of Cd, Cu, Fe, Pb, and inversely associated with Se, Zn, and Mn.	Iron	86-88	coiled-coil domain containing 6	Homo sapiens	25-28
33855731-7	2021	Iron overload decreased expressions of adiponectin and leptin both in vivo and in vitro.	Iron	0-4	adiponectin, C1Q and collagen domain containing	Mus musculus	39-50
33835027-0	2021	Augmenter of Liver Regeneration regulates cellular iron homeostatis by modulating mitochondrial transport of ATP-binding cassette B8.	Iron	51-55	growth factor, augmenter of liver regeneration	Homo sapiens	0-31
33835027-2	2021	Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein import pathway, results in impaired cytosolic Fe/S cluster biogenesis in mammalian cells.	Iron	132-134	growth factor, augmenter of liver regeneration	Homo sapiens	34-37
30811632-5	2019	METHODS AND RESULTS: We first investigated the mRNA level of iron metabolism-related genes, including hepcidin, ferroportin 1 (FPN-1) and transferrin receptor (TFR)-1/2.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	102-110
30811632-5	2019	METHODS AND RESULTS: We first investigated the mRNA level of iron metabolism-related genes, including hepcidin, ferroportin 1 (FPN-1) and transferrin receptor (TFR)-1/2.	Iron	61-65	solute carrier family 40 member 1	Homo sapiens	112-125
33835027-2	2021	Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein import pathway, results in impaired cytosolic Fe/S cluster biogenesis in mammalian cells.	Iron	132-134	growth factor, augmenter of liver regeneration	Homo sapiens	74-77
30811632-5	2019	METHODS AND RESULTS: We first investigated the mRNA level of iron metabolism-related genes, including hepcidin, ferroportin 1 (FPN-1) and transferrin receptor (TFR)-1/2.	Iron	61-65	solute carrier family 40 member 1	Homo sapiens	127-132
33835027-4	2021	Downregulation of ALR impairs mitochondrial ABCB8 import, reduces cytoplasmic Fe/S cluster maturation, and increases cellular iron through the iron regulatory protein-iron response element system.	Iron	126-130	growth factor, augmenter of liver regeneration	Homo sapiens	18-21
30811632-5	2019	METHODS AND RESULTS: We first investigated the mRNA level of iron metabolism-related genes, including hepcidin, ferroportin 1 (FPN-1) and transferrin receptor (TFR)-1/2.	Iron	61-65	transferrin receptor 2	Homo sapiens	138-168
31125976-1	2019	Lactoferrin (LF) is an iron-binding glycoprotein that plays an important role in promoting bone formation and inhibiting bone resorption; however, its effects on senile osteoporosis remain unknown.	Iron	23-27	lactotransferrin	Mus musculus	0-11
33835027-4	2021	Downregulation of ALR impairs mitochondrial ABCB8 import, reduces cytoplasmic Fe/S cluster maturation, and increases cellular iron through the iron regulatory protein-iron response element system.	Iron	143-147	growth factor, augmenter of liver regeneration	Homo sapiens	18-21
33835027-4	2021	Downregulation of ALR impairs mitochondrial ABCB8 import, reduces cytoplasmic Fe/S cluster maturation, and increases cellular iron through the iron regulatory protein-iron response element system.	Iron	143-147	growth factor, augmenter of liver regeneration	Homo sapiens	18-21
33843816-1	2021	With increased life expectancy among patients with beta-thalassemia major (beta-TM) renal insufficiency has been frequently noted because of the persistence of anemia, iron overload and some drug side effects.	Iron	168-172	ATM serine/threonine kinase	Homo sapiens	75-82
31067491-3	2019	The biological functions affected by PGRMC1 include cholesterol/steroid biosynthesis and metabolism, iron homeostasis and heme trafficking, autophagy, regulation of cell cycle and proliferation, cell migration and invasion.	Iron	101-105	progesterone receptor membrane component 1	Homo sapiens	37-43
33843816-10	2021	Controlling anemia by maintaining appropriate hemoglobin level with close monitoring of iron overload are also recommended to preserve renal function among beta-TM patients.	Iron	88-92	ATM serine/threonine kinase	Homo sapiens	156-163
33916457-1	2021	Human CISD2 and mitoNEET are two NEET proteins anchored in the endoplasmic reticulum and mitochondria membranes respectively, with an Fe-S containing domain stretching out in the cytosol.	Iron	134-138	CDGSH iron sulfur domain 1	Homo sapiens	16-24
31040174-0	2019	Calcium-Promoted Interaction between the C2-Domain Protein EHB1 and Metal Transporter IRT1 Inhibits Arabidopsis Iron Acquisition.	Iron	112-116	Calcium-dependent lipid-binding (CaLB domain) family protein	Arabidopsis thaliana	59-63
31040174-8	2019	Genetic and physiological analyses indicated that EHB1 acts as a negative regulator of iron acquisition.	Iron	87-91	Calcium-dependent lipid-binding (CaLB domain) family protein	Arabidopsis thaliana	50-54
31040174-9	2019	The presence of EHB1 prevented the IRT1-mediated complementation of iron-deficient fet3fet4 yeast (Saccharomyces cerevisiae).	Iron	68-72	Calcium-dependent lipid-binding (CaLB domain) family protein	Arabidopsis thaliana	16-20
31040174-10	2019	Our data suggest that EHB1 acts as a direct inhibitor of IRT1-mediated iron import into the cell.	Iron	71-75	Calcium-dependent lipid-binding (CaLB domain) family protein	Arabidopsis thaliana	22-26
31263155-2	2019	Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in multiple brain regions and that this was paralleled by increased oxidative damage and deficits in cognition and memory.	Iron	108-112	ceruloplasmin	Mus musculus	55-68
33709693-0	2021	Rip It off: Nitro to Nitroso Reduction by Iron Half-Sandwich Complexes.	Iron	42-46	receptor interacting serine/threonine kinase 1	Homo sapiens	0-3
31417259-0	2019	alpha-synuclein interaction with zero-valent iron nanoparticles accelerates structural rearrangement into amyloid-susceptible structure with increased cytotoxic tendency.	Iron	45-49	synuclein alpha	Homo sapiens	0-15
33559926-12	2021	Whole-body iron stores were lower after training, as indicated by decreased plasma concentrations of ferritin (p = 3E-5 ) and hepcidin (p = 0.02) without any change in C-reactive protein.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	126-134
31235814-0	2019	Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression.	Iron	0-4	synuclein alpha	Homo sapiens	93-108
31220970-2	2021	The role of hepcidin as a hormone in iron metabolism along with its diagnostic cut-off values and its sensitivity and specificity among pregnant women with iron deficiency anemia (IDA) was examined in this study.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	12-20
30878939-1	2019	Removal of cadmium (Cd2+), a highly toxic heavy metal, from aqueous solutions was investigated using nano zerovalent iron (Fe0).	Iron	117-121	CD2 molecule	Homo sapiens	20-23
30878939-1	2019	Removal of cadmium (Cd2+), a highly toxic heavy metal, from aqueous solutions was investigated using nano zerovalent iron (Fe0).	Iron	123-126	CD2 molecule	Homo sapiens	20-23
30878939-3	2019	At a reaction time of 20 min, 85% and 96% Cd2+ was removed by Fe0 and Bi/Fe0, respectively, at first cycle using [Cd2+]0 = 10 mg/L and [Fe0]0 = [Bi/Fe0]0 = 1.0 g/L.	Iron	62-65	CD2 molecule	Homo sapiens	42-45
33898949-4	2021	Here, we show with gene knockouts and siRNA knockdowns that two Roquin paralogs are major mediators of iron-regulated changes to the steady-state TfR1 mRNA level within four different cell types (HAP1, HUVEC, L-M, and MEF).	Iron	103-107	E74 like ETS transcription factor 4	Homo sapiens	218-221
30878939-3	2019	At a reaction time of 20 min, 85% and 96% Cd2+ was removed by Fe0 and Bi/Fe0, respectively, at first cycle using [Cd2+]0 = 10 mg/L and [Fe0]0 = [Bi/Fe0]0 = 1.0 g/L.	Iron	73-76	CD2 molecule	Homo sapiens	42-45
30878939-3	2019	At a reaction time of 20 min, 85% and 96% Cd2+ was removed by Fe0 and Bi/Fe0, respectively, at first cycle using [Cd2+]0 = 10 mg/L and [Fe0]0 = [Bi/Fe0]0 = 1.0 g/L.	Iron	73-76	CD2 molecule	Homo sapiens	42-45
30878939-3	2019	At a reaction time of 20 min, 85% and 96% Cd2+ was removed by Fe0 and Bi/Fe0, respectively, at first cycle using [Cd2+]0 = 10 mg/L and [Fe0]0 = [Bi/Fe0]0 = 1.0 g/L.	Iron	73-76	CD2 molecule	Homo sapiens	42-45
34027264-1	2021	Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
30878939-4	2019	However, Cd2+ removal efficiency was reduced to 12% and 80% at sixth cycle by Fe0 and Bi/Fe0, respectively.	Iron	78-81	CD2 molecule	Homo sapiens	9-12
34027264-1	2021	Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	0-8
34027264-2	2021	Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	0-8
34027264-2	2021	Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	0-8
31195607-4	2019	Univariate analysis defined for the whole group of children revealed significant associations between the concentration of hepcidin and other iron status parameters.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	123-131
34027264-3	2021	Hepcidin expression is influenced by several factors that include serum and liver iron stores, erythropoiesis, hypoxia, inflammation, and infection.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
34027264-5	2021	In contrast, inflammation and infection are associated with increased hepcidin production to sequester iron intracellularly as a means of depriving microorganisms of iron.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	70-78
31059232-1	2019	We report a method where the refractive index increments of an iron storage protein, ferritin, and apoferritin (ferritin minus iron) were measured over the wavelength range of 450-678 nm to determine the average iron content of the protein.	Iron	127-131	ferritin heavy chain 1	Homo sapiens	99-110
31059232-1	2019	We report a method where the refractive index increments of an iron storage protein, ferritin, and apoferritin (ferritin minus iron) were measured over the wavelength range of 450-678 nm to determine the average iron content of the protein.	Iron	127-131	ferritin heavy chain 1	Homo sapiens	99-110
34027264-5	2021	In contrast, inflammation and infection are associated with increased hepcidin production to sequester iron intracellularly as a means of depriving microorganisms of iron.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	70-78
34027264-7	2021	The bone morphogenetic protein (BMP)-mothers against decapentaplegic homolog (SMAD) pathway is a major positive driver of hepcidin expression in response to either increased circulating iron in the form of transferrin or iron loading in organs.	Iron	186-190	hepcidin antimicrobial peptide	Homo sapiens	122-130
34027264-7	2021	The bone morphogenetic protein (BMP)-mothers against decapentaplegic homolog (SMAD) pathway is a major positive driver of hepcidin expression in response to either increased circulating iron in the form of transferrin or iron loading in organs.	Iron	221-225	hepcidin antimicrobial peptide	Homo sapiens	122-130
30903835-2	2019	The effectiveness of arsenic removal from As(V) solutions using granular activated carbon (GAC) (zero point of charge (ZPC) pH 3.2) and iron incorporated GAC (GAC-Fe) (ZPC pH 8.0) was studied at 25 +- 1  C. The batch study confirmed that GAC-Fe had higher Langmuir adsorption capacity at pH 6 (1.43 mg As/g) than GAC (1.01 mg As/g).	Iron	136-140	glutaminase	Homo sapiens	154-157
34027264-8	2021	Hereditary hemochromatosis (HH) consists of several inherited disorders that cause inappropriately reduced hepcidin expression in response to body iron stores, leading to increased iron absorption from a normal diet.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	107-115
34027264-8	2021	Hereditary hemochromatosis (HH) consists of several inherited disorders that cause inappropriately reduced hepcidin expression in response to body iron stores, leading to increased iron absorption from a normal diet.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	107-115
34027264-9	2021	The most common form of HH is due to a mutation in the HFE gene, which causes a failure in the hepatocyte iron-sensing mechanism, leading to reduced hepcidin expression; the clinical manifestations of HFE-HH include increased serum transferrin-iron saturation and progressive iron loading in the liver and other tissues over time among patients who express the disease phenotype.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	149-157
33837730-0	2021	Iron chelates hitch a ride on PAT1.	Iron	0-4	solute carrier family 36 member 1	Homo sapiens	30-34
31146486-1	2019	Lactoferrin (LF) is a Fe3+-binding glycoprotein, that was first recognized in milk and then in other epithelial secretions and barrier body fluids to which many different functions have been attributed to LF including protection from iron-induced lipid peroxidation, immunomodulation, cell growth regulation, DNA and RNA binding, as well as transcriptional activation, ets.	Iron	234-238	lactotransferrin	Bos taurus	0-11
31146486-1	2019	Lactoferrin (LF) is a Fe3+-binding glycoprotein, that was first recognized in milk and then in other epithelial secretions and barrier body fluids to which many different functions have been attributed to LF including protection from iron-induced lipid peroxidation, immunomodulation, cell growth regulation, DNA and RNA binding, as well as transcriptional activation, ets.	Iron	234-238	lactotransferrin	Bos taurus	13-15
33735594-2	2021	Oral iron absorption may be impeded by elevated circulating hepcidin levels.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	60-68
31172012-4	2019	More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds.	Iron	134-138	Yap5p	Saccharomyces cerevisiae S288C	123-127
33712721-2	2021	Hepcidin is a hormone that diminishes iron bioavailability.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	0-8
31404374-2	2019	Moreover, in affected women, serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) are also shown to be reduced, suggesting that the peripheral excess of iron could also harm the ovarian reserve.	Iron	167-171	anti-Mullerian hormone	Homo sapiens	59-62
33712721-9	2021	Reduced iron absorption is also present and has been reported in some diseases with transfusion IOL, in which serum hepcidin is usually high.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	116-124
31086210-1	2019	Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
33664298-0	2021	Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth.	Iron	69-73	synuclein alpha	Homo sapiens	13-28
31067696-0	2019	Deregulation of Hepatic Mek1/2-Erk1/2 Signaling Module in Iron Overload Conditions.	Iron	58-62	mitogen-activated protein kinase kinase 1	Homo sapiens	24-30
31067696-1	2019	The liver, through the production of iron hormone hepcidin, controls body iron levels.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	50-58
31067696-1	2019	The liver, through the production of iron hormone hepcidin, controls body iron levels.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	50-58
31067696-2	2019	High liver iron levels and deregulated hepcidin expression are commonly observed in many liver diseases including highly prevalent genetic iron overload disorders.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	39-47
33664298-5	2021	In the excised SNCA-knockout xenografts, TfR1 decreased 3.3-fold, ferritin increased 6.2-fold, the divalent metal ion transporter 1 (DMT1) increased threefold, and the iron exporter ferroportin (FPN1) decreased twofold relative to control xenografts.	Iron	168-172	synuclein alpha	Homo sapiens	15-19
31067696-5	2019	Our data demonstrate that hepatic iron overload associates with a decline in the activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) kinase (Mek1/2) pathway by selectively affecting the phosphorylation of Erk1/2.	Iron	34-38	mitogen-activated protein kinase kinase 1	Homo sapiens	187-193
31067696-6	2019	We propose that Mek1/2-Erk1/2 signaling is uncoupled from iron-Bmp-Smad-mediated hepcidin induction and that it may contribute to a number of liver pathologies in addition to toxic effects of iron.	Iron	192-196	mitogen-activated protein kinase kinase 1	Homo sapiens	16-22
33664298-7	2021	Collectively, depletion of alpha-syn in SK-Mel-28 cells dysregulates cellular iron metabolism, especially in xenografts, yielding melanoma cells that are deficient in TfR1 and FPN1, that accumulate ferric iron and ferritin, and that undergo apoptosis relative to control cells expressing alpha-syn.	Iron	78-82	synuclein alpha	Homo sapiens	27-36
33739032-8	2021	Ferrous iron is absorbed in the brush border of duodenal enterocytes through a carrier protein, divalent metal transporter 1 (DMT1).	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	96-124
30334902-3	2019	Recently, hepcidin, a protein hormone synthesized in the liver and excreted in urine, has been shown to be related to iron status.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	10-18
30852438-2	2019	Here we show that SLC40A1, the gene encoding the iron exporter ferroportin (FPN), is variably expressed among primary AMLs and that low levels are associated with good prognosis and improved outcomes.	Iron	49-53	solute carrier family 40 member 1	Homo sapiens	18-25
33739032-8	2021	Ferrous iron is absorbed in the brush border of duodenal enterocytes through a carrier protein, divalent metal transporter 1 (DMT1).	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	126-130
33739032-11	2021	Hepcidin acts as a gatekeeper and controls iron absorption by enterocytes and macrophages.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
31919087-5	2021	Our data shows two stages for the progression of anemia, to which hepcidin contributes: a first stage, when anemia develops, with a likely cytokine-mediated stimulation of hepcidin and subsequent limitation in iron availability and erythropoiesis, and a second stage, of recovery, where hepcidin elevation declines due to the decreased inflammatory signal and increased production of erythroid regulators by the kidney, spleen and bone marrow, thus leading to an increase in iron release and availability and enhanced erythropoiesis.	Iron	210-214	hepcidin antimicrobial peptide	Homo sapiens	66-74
31179408-0	2019	Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.	Iron	60-64	egl-9 family hypoxia-inducible factor 1	Mus musculus	130-175
31919087-5	2021	Our data shows two stages for the progression of anemia, to which hepcidin contributes: a first stage, when anemia develops, with a likely cytokine-mediated stimulation of hepcidin and subsequent limitation in iron availability and erythropoiesis, and a second stage, of recovery, where hepcidin elevation declines due to the decreased inflammatory signal and increased production of erythroid regulators by the kidney, spleen and bone marrow, thus leading to an increase in iron release and availability and enhanced erythropoiesis.	Iron	475-479	hepcidin antimicrobial peptide	Homo sapiens	66-74
32446932-1	2021	OBJECTIVE/BACKGROUND: Mutations in transmembrane protease serine 6 (TMPRSS6) gene induce high hepcidin level, which causes iron-refractory iron deficiency anemia (IRIDA) by preventing duodenal iron absorption.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	94-102
30763100-0	2019	Multiconfiguration Pair-Density Functional Theory for Iron Porphyrin with CAS, RAS, and DMRG Active Spaces.	Iron	54-58	BCAR1 scaffold protein, Cas family member	Homo sapiens	74-77
32895881-0	2021	The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder.	Iron	92-96	transferrin receptor 2	Homo sapiens	42-46
32895881-0	2021	The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	47-50
30865432-0	2019	Coupling Nucleotide Binding and Hydrolysis to Iron-Sulfur Cluster Acquisition and Transfer Revealed through Genetic Dissection of the Nbp35 ATPase Site.	Iron	46-50	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	134-139
32895881-1	2021	The mutation of the homeostatic iron regulatory genes (HFE) impaired the hepatic hepcidin transcription leading to the chronic excess of the iron pool, with the adverse consequences of free radical oxidative damages.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	81-89
30865432-1	2019	The cytosolic iron-sulfur cluster assembly (CIA) scaffold, comprising Nbp35 and Cfd1 in yeast, assembles iron-sulfur (FeS) clusters destined for cytosolic and nuclear enzymes.	Iron	14-18	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	70-75
32895881-1	2021	The mutation of the homeostatic iron regulatory genes (HFE) impaired the hepatic hepcidin transcription leading to the chronic excess of the iron pool, with the adverse consequences of free radical oxidative damages.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	81-89
30865432-1	2019	The cytosolic iron-sulfur cluster assembly (CIA) scaffold, comprising Nbp35 and Cfd1 in yeast, assembles iron-sulfur (FeS) clusters destined for cytosolic and nuclear enzymes.	Iron	14-18	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	80-84
30865432-1	2019	The cytosolic iron-sulfur cluster assembly (CIA) scaffold, comprising Nbp35 and Cfd1 in yeast, assembles iron-sulfur (FeS) clusters destined for cytosolic and nuclear enzymes.	Iron	118-121	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	70-75
30865432-1	2019	The cytosolic iron-sulfur cluster assembly (CIA) scaffold, comprising Nbp35 and Cfd1 in yeast, assembles iron-sulfur (FeS) clusters destined for cytosolic and nuclear enzymes.	Iron	118-121	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	80-84
32895881-10	2021	After that, the hepcidin transcription started to kick in with the resulting decreased serum iron levels and deterioration of clinical symptoms.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	16-24
33012780-1	2021	OBJECTIVE: To determine why serum ferritin and reticulocyte hemoglobin (RET-He), drawn to assess neonatal iron sufficiency, sometimes have markedly discordant results.	Iron	106-110	ret proto-oncogene	Homo sapiens	72-75
30995819-1	2019	Erythroferrone (ERFE) is a hepcidin inhibitor whose synthesis is stimulated by erythropoietin, which increases iron absorption and mobilization.	Iron	111-115	erythroferrone	Homo sapiens	16-20
30995819-4	2019	In the hemodialysis cohort, serum ERFE associated directly with erythropoiesis stimulating agents (ESA) dose (p &lt; 0.001) and inversely with serum iron and ferritin (p &lt; 0.001).	Iron	149-153	erythroferrone	Homo sapiens	34-38
30958854-4	2019	Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA.	Iron	179-183	erythropoietin	Mus musculus	131-145
30958854-7	2019	Erythropoietin-treated iron-deficient mice displayed smaller spleen size in comparison with erythropoietin-treated mice kept on a control diet.	Iron	23-27	erythropoietin	Mus musculus	0-14
33026897-0	2021	Serum hepcidin concentrations in relation to iron status in children with type 1 diabetes.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	6-14
30709903-0	2019	Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB.	Iron	0-4	leptin	Mus musculus	20-26
33026897-2	2021	We hypothesized that in T1D children with FID, hepcidin concentrations are increased compared to those with normal iron status and those with absolute iron deficiency (AID).	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	47-55
30709903-1	2019	We previously reported that iron down-regulates transcription of the leptin gene by increasing occupancy of phosphorylated cAMP response element-binding protein (pCREB) at two sites in the leptin gene promoter.	Iron	28-32	leptin	Mus musculus	69-75
33026897-10	2021	The median (Q1-Q3) hepcidin concentration in patients with normal iron status was 1.8 nmol/l (0.9-3.3), in AID-patients, 0.4 nmol/l (0.4-0.4) and in FID-patients, 1.6 nmol/l (0.7-3.5).	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	19-27
30709903-1	2019	We previously reported that iron down-regulates transcription of the leptin gene by increasing occupancy of phosphorylated cAMP response element-binding protein (pCREB) at two sites in the leptin gene promoter.	Iron	28-32	leptin	Mus musculus	189-195
30709903-3	2019	We therefore investigated whether O-glycosylation plays a role in iron- and CREB-mediated regulation of leptin.	Iron	66-70	leptin	Mus musculus	104-110
30709903-4	2019	We found that high iron decreases protein O-GlcNAcylation both in cultured 3T3-L1 adipocytes and in mice fed high-iron diets and down-regulates leptin mRNA and protein levels.	Iron	19-23	leptin	Mus musculus	144-150
30709903-6	2019	The increased leptin levels induced by glucosamine were susceptible to the inhibition by iron, but in the case of OGT inhibition, iron did not further decrease leptin.	Iron	89-93	leptin	Mus musculus	14-20
30709903-8	2019	Of note, iron increased the occupancy of pCREB and decreased the occupancy of O-GlcNAcylated CREB on the leptin promoter.	Iron	9-13	leptin	Mus musculus	105-111
30709903-9	2019	These patterns observed in our experimental models suggest that iron exerts its effects on leptin by decreasing O-glycosylation and not by increasing protein deglycosylation and that neither O-GlcNAcase nor OGT mRNA and protein levels are affected by iron.	Iron	64-68	leptin	Mus musculus	91-97
33632934-9	2021	Germ-line PIGA mutations are generally thought to be lethal in utero; however, there are reports of infants with PIGA mutations associated with dysmorphic features, neurologic manifestations, biochemical perturbations, and systemic iron overload; development can be normal up to 6 months of age.	Iron	232-236	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	10-14
30709903-10	2019	We conclude that iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB.	Iron	17-21	leptin	Mus musculus	37-43
30709903-10	2019	We conclude that iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB.	Iron	17-21	leptin	Mus musculus	126-132
33632934-9	2021	Germ-line PIGA mutations are generally thought to be lethal in utero; however, there are reports of infants with PIGA mutations associated with dysmorphic features, neurologic manifestations, biochemical perturbations, and systemic iron overload; development can be normal up to 6 months of age.	Iron	232-236	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	113-117
30769268-22	2019	Comparison between three-dimensional structures (3D) of COX1 protein model in E. granulosus s.s. and E. canadensis species demonstrated an additional helix with two conserved iron binding sites in the COX1 protein of E. granulosus s.s. species.	Iron	175-179	COX1	Echinococcus canadensis	201-205
33249618-1	2021	The use of oral contraceptives (OCs) by female athletes may lead to improved iron status, possibly through the regulation of hepcidin by sex hormones.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	125-133
30784615-2	2019	This article highlights the potential therapeutic benefit of exogenous hepcidin to prevent and treat iron-induced injury, specifically in the management of infection from enteric gram-negative bacilli or fungi, malaria, sepsis, acute kidney injury, trauma, transfusion, cardiopulmonary bypass surgery, and liver disease.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	71-79
33671004-8	2021	In contrast, in ferroptosis, HO-1 may play a pro-death role via enhancing iron release.	Iron	74-78	heme oxygenase 1	Homo sapiens	29-33
30945556-4	2019	Another related TTSP, matriptase-2 is expressed in the liver and functions by regulating iron homoeostasis through the cleavage of hemojuvelin and thus is implicated in iron overload diseases.	Iron	89-93	hemojuvelin BMP co-receptor	Homo sapiens	131-142
30945556-4	2019	Another related TTSP, matriptase-2 is expressed in the liver and functions by regulating iron homoeostasis through the cleavage of hemojuvelin and thus is implicated in iron overload diseases.	Iron	169-173	hemojuvelin BMP co-receptor	Homo sapiens	131-142
33670876-0	2021	Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2alpha-Ve-Cadherin Pathway.	Iron	12-16	endothelial PAS domain protein 1	Homo sapiens	77-86
30988565-0	2019	Impact of Genotype of Beta Globin Gene on Hepatic and Myocardial Iron Content in Egyptian Patients with Beta Thalassemia.	Iron	65-69	hemoglobin subunit beta	Homo sapiens	22-33
33670876-6	2021	We found that the iron chelator, Desferal  significantly decreased MRF and apoptosis subsequent to barrier insult, while also rescuing barrier integrity by inhibiting the labile iron pool increase, inducing HIF2alpha expression and preventing the degradation of Ve-cadherin specifically on the endothelial cell surface.	Iron	18-22	endothelial PAS domain protein 1	Homo sapiens	207-216
33565577-1	2021	Hepcidin is a key iron-regulatory hormone, the production of which is controlled by iron stores, inflammation, hypoxia and erythropoiesis.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
30584945-7	2019	After iron supplement administration, the SUE-iron (III) showed effective effect on returning hemoglobin, red blood cells, serum iron, and erythropoietin to the normal levels.	Iron	46-50	erythropoietin	Rattus norvegicus	139-153
30584945-7	2019	After iron supplement administration, the SUE-iron (III) showed effective effect on returning hemoglobin, red blood cells, serum iron, and erythropoietin to the normal levels.	Iron	46-50	erythropoietin	Rattus norvegicus	139-153
33565577-1	2021	Hepcidin is a key iron-regulatory hormone, the production of which is controlled by iron stores, inflammation, hypoxia and erythropoiesis.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
33565577-2	2021	The regulation of iron by hepcidin is of clinical importance in thalassemia patients in which anemia occurs along with iron overload.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	26-34
33565577-2	2021	The regulation of iron by hepcidin is of clinical importance in thalassemia patients in which anemia occurs along with iron overload.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	26-34
33565577-9	2021	Likely, the regulation of hepcidin in thalassemia patients is affected more by erythropoietic activity than iron storage.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	26-34
30132882-4	2019	We demonstrated that the iron exporter ferroportin 1 (FPN1) and iron importer divalent metal transporter 1 (DMT1) were upregulated and iron content was decreased after estrogen treatment for 12 hr in primary cultured astrocytes.	Iron	25-29	solute carrier family 40 member 1	Homo sapiens	39-52
33606984-0	2021	"Iron"ing out hemophagocytosis through PIEZO1.	Iron	1-5	piezo type mechanosensitive ion channel component 1	Homo sapiens	39-45
30132882-4	2019	We demonstrated that the iron exporter ferroportin 1 (FPN1) and iron importer divalent metal transporter 1 (DMT1) were upregulated and iron content was decreased after estrogen treatment for 12 hr in primary cultured astrocytes.	Iron	25-29	solute carrier family 40 member 1	Homo sapiens	54-58
33606984-2	2021	reveal a mechanistic role for PIEZO1 in iron homeostasis through molecular genetic mouse studies.	Iron	40-44	piezo-type mechanosensitive ion channel component 1	Mus musculus	30-36
30870050-3	2019	Divalent metal transporter 1 (DMT1) mediates the uptake of iron into the cell.	Iron	59-63	solute carrier family 11 member 2	Homo sapiens	0-28
33609526-0	2021	FLCN regulates transferrin receptor 1 transport and iron homeostasis.	Iron	52-56	folliculin	Homo sapiens	0-4
30870050-3	2019	Divalent metal transporter 1 (DMT1) mediates the uptake of iron into the cell.	Iron	59-63	solute carrier family 11 member 2	Homo sapiens	30-34
33609526-4	2021	Here, we used human kidney-derived HEK293 cells as a model, and we report that FLCN promotes the binding of Rab11A with transferrin receptor 1 (TfR1), which is required for iron uptake through continuous trafficking between the cell surface and the cytoplasm.	Iron	173-177	folliculin	Homo sapiens	79-83
30917125-1	2019	In chronic kidney disease both renal insufficiency and chronic inflammation trigger elevated hepcidin levels, which impairs iron uptake, availability.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	93-101
33592127-3	2021	Anemia is a potent driver of FGF23 secretion; therefore, a HIF-PHI (hypoxia-inducible factor prolyl hydroxylase inhibitor) currently in clinical trials to elevate endogenous EPO to resolve anemia, was tested for effects on iron utilization and FGF23-related parameters in a CKD mouse model.	Iron	223-227	erythropoietin	Mus musculus	174-177
30796846-2	2019	The aim of this study was to investigate the effect of iron therapy on appetite, growth and plasma ghrelin and leptin levels in children aged between 12 and 24 months with isolated nutritional iron deficiency anemia.	Iron	55-59	leptin	Homo sapiens	111-117
33665641-6	2021	Findings: We show that low serum iron (hypoferremia), caused by increased hepcidin, severely impairs effector and memory responses to immunizations.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	74-82
31496908-10	2019	The ferroxidase activity of ceruloplasmin plays a crucial role in iron homeostasis and lowers oxidative stress by reducing the detrimental effects of iron.	Iron	66-70	ceruloplasmin	Homo sapiens	28-41
31496908-10	2019	The ferroxidase activity of ceruloplasmin plays a crucial role in iron homeostasis and lowers oxidative stress by reducing the detrimental effects of iron.	Iron	150-154	ceruloplasmin	Homo sapiens	28-41
33597821-10	2021	Iron trafficking associated with the efflux protein ferroportin and influx protein divalent metal transporter (DMT)1 was affected differently in all three cell types.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	92-116
33440237-6	2021	In addition, special attention is addressed to the possible relationship between cellular iron overload and key pathological features of selected neurodegenerative diseases, such as beta-amyloid and tau proteins, alpha-synuclein, and demyelination.	Iron	90-94	microtubule associated protein tau	Homo sapiens	199-202
33440237-6	2021	In addition, special attention is addressed to the possible relationship between cellular iron overload and key pathological features of selected neurodegenerative diseases, such as beta-amyloid and tau proteins, alpha-synuclein, and demyelination.	Iron	90-94	synuclein alpha	Homo sapiens	213-228
32818833-5	2021	Compared with H-LF sample, the H-LN0.15F0.85 sample exhibited the highest catalytic activity, which was attributable to the highest surface coverage of metals as well as the synergistic effect of Fe and Ni species.	Iron	196-198	glucosamine-6-phosphate deaminase 1	Homo sapiens	31-35
33536631-4	2021	Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload.	Iron	58-62	solute carrier family 11 member 2	Homo sapiens	23-30
33536631-5	2021	A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia.	Iron	77-81	HBS1 like translational GTPase	Homo sapiens	2-7
33536631-5	2021	A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia.	Iron	77-81	MYB proto-oncogene, transcription factor	Homo sapiens	8-11
32866306-3	2021	Recently, erythroferrone (ERFE) was recognized as a novel negative regulator of hepcidin that can elevate nutritional iron absorption and macrophagic iron egress for enhanced erythropoiesis.	Iron	118-122	erythroferrone	Homo sapiens	26-30
32866306-3	2021	Recently, erythroferrone (ERFE) was recognized as a novel negative regulator of hepcidin that can elevate nutritional iron absorption and macrophagic iron egress for enhanced erythropoiesis.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	80-88
32866306-3	2021	Recently, erythroferrone (ERFE) was recognized as a novel negative regulator of hepcidin that can elevate nutritional iron absorption and macrophagic iron egress for enhanced erythropoiesis.	Iron	150-154	erythroferrone	Homo sapiens	26-30
32866306-3	2021	Recently, erythroferrone (ERFE) was recognized as a novel negative regulator of hepcidin that can elevate nutritional iron absorption and macrophagic iron egress for enhanced erythropoiesis.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	80-88
32866306-5	2021	In the current study, we discovered disordered maternal iron homeostasis in women who had spontaneous abortions during early pregnancy, as characterized by increased serum iron and hepcidin levels, and conversely, reduced serum ERFE levels, compared to healthy control individuals and women with normal pregnancy.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	181-189
32866306-5	2021	In the current study, we discovered disordered maternal iron homeostasis in women who had spontaneous abortions during early pregnancy, as characterized by increased serum iron and hepcidin levels, and conversely, reduced serum ERFE levels, compared to healthy control individuals and women with normal pregnancy.	Iron	56-60	erythroferrone	Homo sapiens	228-232
31919080-1	2021	The erythropoietin (Epo)-erythroferrone (ERFE)-hepcidin axis coordinates erythropoiesis and iron homeostasis.	Iron	92-96	erythroferrone	Homo sapiens	41-45
31919080-1	2021	The erythropoietin (Epo)-erythroferrone (ERFE)-hepcidin axis coordinates erythropoiesis and iron homeostasis.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	47-55
31919080-9	2021	The present results demonstrate that in healthy humans ERFE responds to slightly increased Epo levels not associated with Hbmass expansion and down-regulates hepcidin in an apparently iron-independent way.	Iron	184-188	erythroferrone	Homo sapiens	55-59
33325123-0	2021	Vitamin D rescues pancreatic beta cell dysfunction due to iron overload via elevation of the vitamin D receptor and maintenance of Ca2+ homeostasis.	Iron	58-62	vitamin D receptor	Rattus norvegicus	93-111
33325123-4	2021	METHODS AND RESULTS: We induced iron overload in INS-1 rat insulinoma pancreatic beta cells and found that iron overload dramatically reduced expression of the vitamin D receptor (VDR).	Iron	107-111	vitamin D receptor	Rattus norvegicus	160-178
33325123-4	2021	METHODS AND RESULTS: We induced iron overload in INS-1 rat insulinoma pancreatic beta cells and found that iron overload dramatically reduced expression of the vitamin D receptor (VDR).	Iron	107-111	vitamin D receptor	Rattus norvegicus	180-183
33325123-5	2021	Iron overload-induced beta cell dysfunction was rescued by 1,25(OH)2 D3 cotreatment via restoration of VDR level and the consequent maintenance of Ca2+ homeostasis.	Iron	0-4	vitamin D receptor	Rattus norvegicus	103-106
33514947-4	2021	In this Review, we present an introduction to HO-1 for immunologists, including an overview of its roles in iron metabolism and antioxidant defence, and the factors which regulate its expression.	Iron	108-112	heme oxygenase 1	Homo sapiens	46-50
33584308-0	2020	Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.	Iron	14-18	heme oxygenase 1	Homo sapiens	56-60
33584308-0	2020	Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.	Iron	14-18	glutathione peroxidase 4	Homo sapiens	61-65
33356193-0	2021	Effect of the Electron Density of the Heme Fe Atom on the Nature of Fe-O2 Bonding in Oxy Myoglobin.	Iron	43-45	myoglobin	Homo sapiens	89-98
33356193-0	2021	Effect of the Electron Density of the Heme Fe Atom on the Nature of Fe-O2 Bonding in Oxy Myoglobin.	Iron	68-70	myoglobin	Homo sapiens	89-98
33717488-7	2021	Genomic analysis identified selective sweeps in three genes; fecA, ptsP and ilvG unique to the iron (II) resistant populations, and gene expression studies demonstrated that their cellular response may be to downregulate genes involved in iron transport (cirA and fecA) while increasing the oxidative stress response (oxyR, soxS and soxR) prior to FeSO4 exposure.	Iron	95-99	ferric citrate outer membrane transporter	Escherichia coli str. K-12 substr. MG1655	61-65
33717488-11	2021	Lay summary: The evolution of iron resistance in E. coli leads to multi-drug and general metal resistance through the acquisition of mutations in three genes (fecA, ptsP and ilvG) while also initiating cellular defenses as part of their normal growth process.	Iron	30-34	ferric citrate outer membrane transporter	Escherichia coli str. K-12 substr. MG1655	159-163
33434904-1	2021	In this work we report experimental evidence for the weak high-temperature ferromagnetism in Bi1-xRxFeO3 (R = Dy, Y) compounds by careful characterizations, excluding the possible side-effects from other iron-based impurities.	Iron	204-208	transmembrane BAX inhibitor motif containing 6	Homo sapiens	93-96
33436675-1	2021	Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be membrane-anchored or secreted in serum.	Iron	30-34	melanotransferrin	Homo sapiens	0-17
33436675-1	2021	Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be membrane-anchored or secreted in serum.	Iron	30-34	melanotransferrin	Homo sapiens	19-22
33423253-6	2021	Subsequently, by manipulating the expression of key genes in iron metabolism such as hepcidin and transferrin receptor, researchers have revealed that iron restriction can improve ineffective hematopoiesis and iron overload, which may provide a potential approach for the treatment of thalassemia.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	85-93
33423253-6	2021	Subsequently, by manipulating the expression of key genes in iron metabolism such as hepcidin and transferrin receptor, researchers have revealed that iron restriction can improve ineffective hematopoiesis and iron overload, which may provide a potential approach for the treatment of thalassemia.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	85-93
33423253-6	2021	Subsequently, by manipulating the expression of key genes in iron metabolism such as hepcidin and transferrin receptor, researchers have revealed that iron restriction can improve ineffective hematopoiesis and iron overload, which may provide a potential approach for the treatment of thalassemia.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	85-93
33231101-8	2021	Both iron and its systemic regulator, such as hepcidin, play significant role in regulating erythropoiesis.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	46-54
33489473-2	2021	However, genetically engineered mouse models have revealed that high-iron diets or deletion of pancreatic GPX4 (a key repressor of ferroptosis) accelerate the development of mutant Kras-driven PDAC by activating the STING1/TMEM173-dependent DNA sensor pathway.	Iron	69-73	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	181-185
33049671-4	2021	Cd"s diverse toxic mechanisms are based on its capacity to mimic divalent ions -calcium, zinc, iron- that participate in physiological processes.	Iron	95-99	CDP-diacylglycerol synthase 1	Homo sapiens	0-4
30884885-9	2019	Whereas MT-1G was also induced by zinc and nickel ions and MT-1H by iron, both MT-1A and MT-1M were highly cadmium-specific, which was confirmed for protein using isoform-specific antibodies.	Iron	68-72	metallothionein 1G	Homo sapiens	8-13
30659096-0	2019	SMAD family member 3 (SMAD3) and SMAD4 repress HIF2alpha-dependent iron-regulatory genes.	Iron	67-71	endothelial PAS domain protein 1	Homo sapiens	47-56
30659096-1	2019	Hypoxia-inducible factor 2alpha (HIF2alpha) directly regulates a battery of genes essential for intestinal iron absorption.	Iron	107-111	endothelial PAS domain protein 1	Homo sapiens	0-31
30659096-1	2019	Hypoxia-inducible factor 2alpha (HIF2alpha) directly regulates a battery of genes essential for intestinal iron absorption.	Iron	107-111	endothelial PAS domain protein 1	Homo sapiens	33-42
33157209-4	2021	The SD rat hearts were subjected to 1 h-ischemia plus 3 h-reperfusion, showing myocardial injury (increase in creatine kinase release, infarct size, myocardial fiber loss and disarray) and up-regulation of USP7, p53 and TfR1 concomitant with an increase of ferroptosis (reflecting by accumulation of iron and lipid peroxidation while decrease of glutathione peroxidase activity).	Iron	300-304	ubiquitin specific peptidase 7	Rattus norvegicus	206-210
33157209-7	2021	Consistent with the results in vivo, inhibition or knockdown of USP7 reduced the H/R injury (decrease of LDH release and necrosis) and enhanced the ubiquitination of p53 along with the decreased levels of p53 and TfR1 as well as the attenuated ferroptosis (manifesting as the decreased iron content and lipid peroxidation while the increased GPX activity).	Iron	286-290	ubiquitin specific peptidase 7	Rattus norvegicus	64-68
33079260-2	2021	Early-stage Parkinson"s disease (PD) patients, of less than 5 years disease duration, showed associations of plasmatic ferritin concentrations with both proinflammatory cytokine interleukin-6 and hepcidin, a regulator of iron metabolism as well as clinical measures.	Iron	221-225	hepcidin antimicrobial peptide	Homo sapiens	196-204
30815666-2	2019	Here, by using density functional theory (DFT), we systematically investigate various single transition metal atom (Ti, V, Cr, Mn, Fe, Co, Ni, Ru, Rh and Pd) modified MoP surfaces as potential N2 reduction electrocatalysts for ammonia (NH3) synthesis.	Iron	131-133	opioid receptor mu 1	Homo sapiens	167-170
30664307-3	2019	An operando electrochemical Raman spectroscopy study confirmed the formation of cobalt oxyhydroxide species and the iron stimulated the equilibrium state between Co3+ and Co4+ .	Iron	116-120	complement C4A (Rodgers blood group)	Homo sapiens	171-174
33098823-5	2021	Overexpression of HSF1 not only alleviated PA-induced cell death and lipid peroxidation but also improved disturbed iron homeostasis by regulating the transcription of iron metabolism-related genes (e.g., Fth1, Tfrc, Slc40a1).	Iron	116-120	heat shock transcription factor 1	Rattus norvegicus	18-22
30906244-2	2019	Serum melanotransferrin (MTf), a transferrin homolog capable of reversibly binding iron, has been proposed as a biochemical marker of AD.	Iron	83-87	melanotransferrin	Homo sapiens	6-23
33098823-5	2021	Overexpression of HSF1 not only alleviated PA-induced cell death and lipid peroxidation but also improved disturbed iron homeostasis by regulating the transcription of iron metabolism-related genes (e.g., Fth1, Tfrc, Slc40a1).	Iron	168-172	heat shock transcription factor 1	Rattus norvegicus	18-22
30906244-2	2019	Serum melanotransferrin (MTf), a transferrin homolog capable of reversibly binding iron, has been proposed as a biochemical marker of AD.	Iron	83-87	melanotransferrin	Homo sapiens	25-28
30906244-3	2019	MTf has also been shown to be elevated in iron-rich reactive microglia near amyloid plaques in AD.	Iron	42-46	melanotransferrin	Homo sapiens	0-3
32726602-6	2021	Interestingly, alpha-syn has been functionally linked with the metabolism of both iron and lipid, suggesting a possible interplay between dysregulated alpha-syn and other PD pathological hallmarks related to ferroptosis.	Iron	82-86	synuclein alpha	Homo sapiens	15-24
30623722-7	2019	In patients with tubular dysfunction, enhanced urinary iron and transferrin excretion were associated with distal tubular injury as indicated by increased urinary glutathione S-transferase pi 1-1 (GSTP1-1) excretion.	Iron	55-59	glutathione S-transferase pi 1	Homo sapiens	163-195
30623722-7	2019	In patients with tubular dysfunction, enhanced urinary iron and transferrin excretion were associated with distal tubular injury as indicated by increased urinary glutathione S-transferase pi 1-1 (GSTP1-1) excretion.	Iron	55-59	glutathione S-transferase pi 1	Homo sapiens	197-204
32726602-6	2021	Interestingly, alpha-syn has been functionally linked with the metabolism of both iron and lipid, suggesting a possible interplay between dysregulated alpha-syn and other PD pathological hallmarks related to ferroptosis.	Iron	82-86	synuclein alpha	Homo sapiens	151-160
33396642-1	2020	Mutations in the pantothenate kinase 2 gene (PANK2) are the cause of pantothenate kinase-associated neurodegeneration (PKAN), the most common form of neurodegeneration with brain iron accumulation.	Iron	179-183	pantothenate kinase	Saccharomyces cerevisiae S288C	17-36
33379337-9	2020	Upon iron depletion, Tif51A was down-regulated and Tif51B up-regulated.	Iron	5-9	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	21-27
33374970-2	2020	Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein.	Iron	118-122	lactotransferrin	Bos taurus	93-104
33374970-3	2020	The aim of the present study was to investigate how reducing the iron content and adding bovine lactoferrin to infant formula affects iron status, health and development.	Iron	134-138	lactotransferrin	Bos taurus	96-107
33352721-6	2020	In erythroblasts, both transferrin receptors adopt peculiarities such as an erythroid-specific regulation of TFR1 and a trafficking pathway reliant on TFR2 for iron.	Iron	160-164	transferrin receptor 2	Homo sapiens	151-155
33317411-1	2022	The aim of the current study was to investigate iron metabolism in endurance trained women through the interleukin-6, hepcidin and iron responses to exercise along different endogenous hormonal states.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	118-126
33334885-6	2021	These results imply that PAT1 transports iron as a NA-Fe (II) complex.	Iron	41-45	solute carrier family 36 member 1	Homo sapiens	25-29
33348847-9	2020	This suggests a slower recovery of basal hepcidin levels in postmenopausal women, suggesting interesting applications in order to modify iron homeostasis as appropriate, such as the prevention of iron accumulation or proper timing of iron supplementation.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	41-49
33348847-9	2020	This suggests a slower recovery of basal hepcidin levels in postmenopausal women, suggesting interesting applications in order to modify iron homeostasis as appropriate, such as the prevention of iron accumulation or proper timing of iron supplementation.	Iron	196-200	hepcidin antimicrobial peptide	Homo sapiens	41-49
33348847-9	2020	This suggests a slower recovery of basal hepcidin levels in postmenopausal women, suggesting interesting applications in order to modify iron homeostasis as appropriate, such as the prevention of iron accumulation or proper timing of iron supplementation.	Iron	196-200	hepcidin antimicrobial peptide	Homo sapiens	41-49
33326952-1	2021	BACKGROUND: Hemochromatosis gene (HFE)-associated hereditary hemochromatosis (HH) is characterized by downregulation of hepcidin synthesis, leading to increased intestinal iron absorption.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	120-128
33339332-0	2020	Effect of Chromium and Molybdenum Addition on the Microstructure of In Situ TiC-Reinforced Composite Surface Layers Fabricated on Ductile Cast Iron by Laser Alloying.	Iron	143-147	calpastatin	Homo sapiens	138-142
33363382-0	2020	An Iron Metabolism-Related SLC22A17 for the Prognostic Value of Gastric Cancer.	Iron	3-7	solute carrier family 22 member 17	Homo sapiens	27-35
33363382-3	2020	The aim of this study was to evaluate the effectiveness of SLC22A17, associated with iron metabolism, in predicting the prognosis of GC patients.	Iron	85-89	solute carrier family 22 member 17	Homo sapiens	59-67
33363382-5	2020	We identified an iron metabolism-related SLC22A17 as an independent prognostic factor using univariate and multivariate Cox regression analysis.	Iron	17-21	solute carrier family 22 member 17	Homo sapiens	41-49
33363382-8	2020	Conclusion: We validated that SLC22A17 associated with iron metabolism could serve as a prognostic biomarker for GC patients.	Iron	55-59	solute carrier family 22 member 17	Homo sapiens	30-38
33402866-1	2020	Hephaestin (Hp) is a trans-membrane protein, which plays a critical role in intestinal iron absorption.	Iron	87-91	LOW QUALITY PROTEIN: hephaestin	Cricetulus griseus	0-10
33402866-3	2020	The mutation in the sla protein causes accumulation of dietary iron in duodenal cells, causing severe microcytic hypochromic anaemia.	Iron	63-67	src-like adaptor	Mus musculus	20-23
33402866-5	2020	Hp is homologous to ceruloplasmin (Cp), a member of the family of multi copper ferroxidases (MCFs) and possesses ferroxidase activity that facilitates iron release from the duodenum and load onto the serum iron transport protein transferrin.	Iron	151-155	ceruloplasmin	Cricetulus griseus	20-33
33402866-5	2020	Hp is homologous to ceruloplasmin (Cp), a member of the family of multi copper ferroxidases (MCFs) and possesses ferroxidase activity that facilitates iron release from the duodenum and load onto the serum iron transport protein transferrin.	Iron	151-155	ceruloplasmin	Cricetulus griseus	35-37
33402866-5	2020	Hp is homologous to ceruloplasmin (Cp), a member of the family of multi copper ferroxidases (MCFs) and possesses ferroxidase activity that facilitates iron release from the duodenum and load onto the serum iron transport protein transferrin.	Iron	206-210	ceruloplasmin	Cricetulus griseus	20-33
33402866-5	2020	Hp is homologous to ceruloplasmin (Cp), a member of the family of multi copper ferroxidases (MCFs) and possesses ferroxidase activity that facilitates iron release from the duodenum and load onto the serum iron transport protein transferrin.	Iron	206-210	ceruloplasmin	Cricetulus griseus	35-37
33273016-5	2021	Here, we investigate how the presence of heme, a highly relevant iron source during infection, affects bacterial responses to iron withholding by the innate immune protein calprotectin (CP).	Iron	126-130	ceruloplasmin	Homo sapiens	186-188
33080340-2	2020	In the present study, mice receiving a 12-months 0.3% dextran-iron diet show mild HIO with no detectable oxidative damages in the liver but have infiltrated macrophages and increased IL-6, TNFalpha, AST and ALT since 6-months.	Iron	62-66	glutamic pyruvic transaminase, soluble	Mus musculus	207-210
33405355-5	2020	Further analysis found that the expression of a gene encoding nicotianamine (NA) synthase (NAS1) was dramatically decreased in the hap5a mutant, regardless of the Fe status.	Iron	163-165	nicotianamine synthase	Arabidopsis thaliana	62-89
33405355-7	2020	Moreover, overexpression of NAS1 could rescue the chlorosis phenotype of hap5a in Fe deficient conditions.	Iron	82-84	proteasome regulatory particle base subunit RPN1	Saccharomyces cerevisiae S288C	28-32
33266044-1	2020	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide.	Iron	111-115	heme oxygenase 1	Homo sapiens	0-16
33266044-1	2020	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide.	Iron	111-115	heme oxygenase 1	Homo sapiens	18-22
33243304-4	2021	Our study aim was to test whether reducing inflammation in iron-depleted overweight women with low-grade inflammation would lower serum hepcidin and improve iron absorption with and without ascorbic acid, compared to normal-weight women without inflammation.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	136-144
33211827-4	2020	Using in vitro erythroid differentiation, we show here that GPX4-irreversible inhibition by 1S,3R-RSL3 (RSL3) and its short hairpin RNA-mediated knockdown strongly impaired enucleation in a ferroptosis-independent manner not restored by tocopherol or iron chelators.	Iron	251-255	glutathione peroxidase 4	Homo sapiens	60-64
32629061-0	2020	Copper and iron ions accelerate the prion-like propagation of alpha-synuclein: A vicious cycle in Parkinson"s disease.	Iron	11-15	synuclein alpha	Homo sapiens	62-77
30461080-1	2019	Recent data suggest that the importance of hepcidin goes beyond its classical role in controlling systemic iron metabolism.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	43-51
32629061-4	2020	Here, we reported that copper/iron ions accelerate prion-like propagation of alpha-synuclein fibrils by promoting cellular internalization of alpha-synuclein fibrils, intracellular alpha-synuclein aggregation and the subsequent release of mature fibrils to the extracellular space to induce further propagation.	Iron	30-34	synuclein alpha	Homo sapiens	77-92
30594846-1	2019	Treatment in IRIDA focuses on use of intravenous iron preparations to circumvent oral absorptive defect resulting from high levels of hepcidin due to TMPRSS6 gene variations.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	134-142
32629061-4	2020	Here, we reported that copper/iron ions accelerate prion-like propagation of alpha-synuclein fibrils by promoting cellular internalization of alpha-synuclein fibrils, intracellular alpha-synuclein aggregation and the subsequent release of mature fibrils to the extracellular space to induce further propagation.	Iron	30-34	synuclein alpha	Homo sapiens	142-157
29572098-0	2019	Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity.	Iron	84-88	H3 histone pseudogene 16	Homo sapiens	63-66
29572098-0	2019	Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity.	Iron	84-88	H3 histone pseudogene 16	Homo sapiens	116-119
32629061-4	2020	Here, we reported that copper/iron ions accelerate prion-like propagation of alpha-synuclein fibrils by promoting cellular internalization of alpha-synuclein fibrils, intracellular alpha-synuclein aggregation and the subsequent release of mature fibrils to the extracellular space to induce further propagation.	Iron	30-34	synuclein alpha	Homo sapiens	142-157
29958932-7	2019	In this review, we propose the following four major reasons for oxidative stress in CKD patients: 1) iron is sequestered in cells by proinflammatory cytokines and hepcidin; 2) the reduction in frataxin increases "free" iron in mitochondria; 3) the accumulation of 5-aminolevulinic acid, a heme precursor, has toxic effects on iron and mitochondrial metabolism; and 4) the elevated levels of the metabolic hormone, leptin, promote hepatic hepcidin production.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	163-171
32629061-5	2020	Mechanistically, copper/iron ions enhanced alpha-synuclein fibrils internalization was mediated by negatively charged membrane heparan sulfate proteoglycans (HSPGs).	Iron	24-28	synuclein alpha	Homo sapiens	43-58
29958932-7	2019	In this review, we propose the following four major reasons for oxidative stress in CKD patients: 1) iron is sequestered in cells by proinflammatory cytokines and hepcidin; 2) the reduction in frataxin increases "free" iron in mitochondria; 3) the accumulation of 5-aminolevulinic acid, a heme precursor, has toxic effects on iron and mitochondrial metabolism; and 4) the elevated levels of the metabolic hormone, leptin, promote hepatic hepcidin production.	Iron	101-105	leptin	Homo sapiens	414-420
29958932-7	2019	In this review, we propose the following four major reasons for oxidative stress in CKD patients: 1) iron is sequestered in cells by proinflammatory cytokines and hepcidin; 2) the reduction in frataxin increases "free" iron in mitochondria; 3) the accumulation of 5-aminolevulinic acid, a heme precursor, has toxic effects on iron and mitochondrial metabolism; and 4) the elevated levels of the metabolic hormone, leptin, promote hepatic hepcidin production.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	438-446
32629061-6	2020	alpha-Synuclein fibrils formed in the presence of copper/iron ions were more cytotoxic, causing increased ROS production, cell apoptosis, and shortened the lifespan of a C. elegans PD model overexpressing human alpha-synuclein.	Iron	57-61	synuclein alpha	Homo sapiens	0-15
29969719-6	2019	TfR2 forms a complex with hemochromatosis protein, HFE, and serves as a component of the iron sensing machinery in hepatocytes.	Iron	89-93	transferrin receptor 2	Homo sapiens	0-4
32629061-6	2020	alpha-Synuclein fibrils formed in the presence of copper/iron ions were more cytotoxic, causing increased ROS production, cell apoptosis, and shortened the lifespan of a C. elegans PD model overexpressing human alpha-synuclein.	Iron	57-61	synuclein alpha	Homo sapiens	211-226
29969719-7	2019	Defects in TfR2 cause systemic iron overload, hemochromatosis, through down-regulation of hepcidin.	Iron	31-35	transferrin receptor 2	Homo sapiens	11-15
29969719-7	2019	Defects in TfR2 cause systemic iron overload, hemochromatosis, through down-regulation of hepcidin.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	90-98
32629061-8	2020	Together, our results suggest a new role for heavy metal ions, e.g. copper and iron, in the pathogenesis of PD through accelerating prion-like propagation of alpha-synuclein fibrils.	Iron	79-83	synuclein alpha	Homo sapiens	158-173
29969719-9	2019	TfR2 facilitates iron transport from lysosomes to mitochondria in erythroblasts and dopaminergic neurons.	Iron	17-21	transferrin receptor 2	Homo sapiens	0-4
33281618-5	2020	Moreover, measurement of hepcidin and erythroferrone (ERFE), two key molecules in iron homeostasis and erythropoiesis, is scarcely used in clinical practice and of uncertain utility.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	25-33
29981834-2	2019	By decreasing the transcription of the gene encoding the iron-regulatory hormone hepcidin, erythropoietic activity stimulates iron absorption, as well as the release of iron from recycling macrophages and from stores in hepatocytes.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	81-89
29981834-2	2019	By decreasing the transcription of the gene encoding the iron-regulatory hormone hepcidin, erythropoietic activity stimulates iron absorption, as well as the release of iron from recycling macrophages and from stores in hepatocytes.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	81-89
29981834-2	2019	By decreasing the transcription of the gene encoding the iron-regulatory hormone hepcidin, erythropoietic activity stimulates iron absorption, as well as the release of iron from recycling macrophages and from stores in hepatocytes.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	81-89
29981834-6	2019	By suppressing hepcidin, ERFE facilitates iron delivery during stress erythropoiesis but also contributes to iron overload in anemias with ineffective erythropoiesis.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	15-23
33281618-5	2020	Moreover, measurement of hepcidin and erythroferrone (ERFE), two key molecules in iron homeostasis and erythropoiesis, is scarcely used in clinical practice and of uncertain utility.	Iron	82-86	erythroferrone	Homo sapiens	54-58
30553971-11	2019	Iron chelation in ccRCC cells but not benign renal cells suppressed HIF-1alpha and HIF-2alpha protein levels and transcriptional activity, and the degree and timing of HIF-2alpha suppression correlated with the onset of apoptosis.	Iron	0-4	endothelial PAS domain protein 1	Homo sapiens	83-93
30553971-11	2019	Iron chelation in ccRCC cells but not benign renal cells suppressed HIF-1alpha and HIF-2alpha protein levels and transcriptional activity, and the degree and timing of HIF-2alpha suppression correlated with the onset of apoptosis.	Iron	0-4	endothelial PAS domain protein 1	Homo sapiens	168-178
30553971-15	2019	Future study is warranted to determine if iron deprivation using chelator drugs provides an effective therapeutic strategy for targeting HIF-2alpha and suppressing tumor progression in ccRCC patients.	Iron	42-46	endothelial PAS domain protein 1	Homo sapiens	137-147
33281618-10	2020	Our study illustrates how new technologies, such as NGS, in silico modeling, and measurement of serum hepcidin-25 and ERFE, may help in diagnosing and studying iron loading anemias.	Iron	160-164	erythroferrone	Homo sapiens	118-122
30988248-1	2019	INTRODUCTION: Hepcidin is a key regulator of iron homeostasis, takes part in pathophysiology of anemia and cardiovascular disease in maintenance hemodialysis (MHD) patients.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	14-22
33281618-11	2020	Further studies on the hepcidin-25/ERFE axis in additional patients with XLSA and other iron loading anemias may help in establishing its usefulness in differential diagnosis, and it may also aid our understanding of the pathophysiology of these genetically and phenotypically heterogeneous entities.	Iron	88-92	erythroferrone	Homo sapiens	35-39
33119321-3	2020	When attached to the tip apex, we observe a reproducible Kondo resonance, which splits apart upon tuning the exchange coupling of cobaltocene to an iron atom on the surface.	Iron	148-152	TOR signaling pathway regulator	Homo sapiens	21-24
30737269-8	2019	Other iron markers were also associated with death, but the magnitude of the association was greatest for catalytic iron and hepcidin.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	125-133
32584957-2	2020	In humans and rodents, the iron-regulatory hormone hepcidin is profoundly decreased in pregnant mothers, which is thought to ensure adequate iron availability for transfer across placenta.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	51-59
30260393-6	2019	SAT expression of the ferritin light chain (FTL) gene, encoding ferritin (FT), an intracellular iron storage protein, was negatively correlated to SREBF1, a gene related to lipogenesis.	Iron	96-100	sterol regulatory element binding transcription factor 1	Homo sapiens	147-153
30260393-9	2019	In parallel to increased expression of lipid storage-related genes (mitoNEET, SCD, DGAT2, SREBF1), SAT Tf, SLC40A1 (encoding ferroportin 1, a membrane iron export channel) and hephaestin mRNA levels increased, whereas SAT FTL mRNA decreased, suggesting increased AT iron requirement.	Iron	151-155	solute carrier family 40 member 1	Homo sapiens	107-114
30260393-9	2019	In parallel to increased expression of lipid storage-related genes (mitoNEET, SCD, DGAT2, SREBF1), SAT Tf, SLC40A1 (encoding ferroportin 1, a membrane iron export channel) and hephaestin mRNA levels increased, whereas SAT FTL mRNA decreased, suggesting increased AT iron requirement.	Iron	151-155	solute carrier family 40 member 1	Homo sapiens	125-138
32584957-2	2020	In humans and rodents, the iron-regulatory hormone hepcidin is profoundly decreased in pregnant mothers, which is thought to ensure adequate iron availability for transfer across placenta.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	51-59
32584957-3	2020	However, the fetal liver also produces hepcidin, which may regulate fetal iron endowment by controlling placental iron export.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	39-47
32584957-3	2020	However, the fetal liver also produces hepcidin, which may regulate fetal iron endowment by controlling placental iron export.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	39-47
32873392-0	2020	Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster.	Iron	23-27	PTEN-induced putative kinase 1	Drosophila melanogaster	97-102
32873392-5	2020	Further work demonstrated that dmfrn OE or Fer3HCH knockdown significantly rescued the impaired mitochondrial respiration in PINK1 LOF flies, indicating that dmfrn or Fer3HCH may rescue PINK1 LOF phenotypes through elevating mitochondrial bioavailable iron levels to promote mitochondrial respiration.	Iron	252-256	PTEN-induced putative kinase 1	Drosophila melanogaster	125-130
33048522-0	2020	Single-Molecule Force Spectroscopy Reveals that the Fe-N Bond Enables Multiple Rupture Pathways of the 2Fe2S Cluster in a MitoNEET Monomer.	Iron	52-54	CDGSH iron sulfur domain 1	Homo sapiens	122-130
33048522-1	2020	The mitochondrial outer membrane protein, mitoNEET (mNT), is an iron-sulfur protein containing an Fe2S2(His)1(Cys)3 cluster with a unique single Fe-N bond.	Iron	98-100	CDGSH iron sulfur domain 1	Homo sapiens	42-50
33058681-0	2020	In Situ Generation of Prussian Blue by MIL-53 (Fe) for Point-of-Care Testing of Butyrylcholinesterase Activity Using a Portable High-Throughput Photothermal Device.	Iron	47-49	butyrylcholinesterase	Homo sapiens	80-101
33058681-4	2020	BuChE could "light up" the PT signal through in situ generation of Prussian blue (PB) by MIL-53 (Fe), which allowed us to translate biological signals into temperature signals.	Iron	97-99	butyrylcholinesterase	Homo sapiens	0-5
33058681-6	2020	In addition, the large specific surface area, 3D network structure, and high porosity of MIL-53 (Fe) offered a beneficial platform for its reaction with enzymatic hydrolysate, resulting in high sensing sensitivity and low detection limit (0.3 U L-1), which was at least 20 000 times lower than the normal human serum BuChE activity.	Iron	97-99	butyrylcholinesterase	Homo sapiens	317-322
32918768-5	2020	Spleen iron sequestration could be due to the concomitant increase in serum hepcidin levels (P < .001).	Iron	7-11	hepcidin antimicrobial peptide	Homo sapiens	76-84
33565438-6	2020	Ret-HE mean value in anemic patients was (25.84 +- 4.23 pg) and had good correlation (P <0.001) between Ret-HE, serum iron, ferritin, transferrin, and transferin saturation in dialysis patients.	Iron	118-122	ret proto-oncogene	Homo sapiens	0-3
32805675-7	2020	Antioxidants such as superoxide dismutase (SOD) and Tiron not only scavenged O2- production, but also markedly rescued SLC7A11 down-regulation, GSH depletion, GPx4 inactivation, iron accumulation, LPO, and ferroptosis.	Iron	53-57	solute carrier family 7 member 11	Homo sapiens	119-126
32805675-7	2020	Antioxidants such as superoxide dismutase (SOD) and Tiron not only scavenged O2- production, but also markedly rescued SLC7A11 down-regulation, GSH depletion, GPx4 inactivation, iron accumulation, LPO, and ferroptosis.	Iron	53-57	glutathione peroxidase 4	Homo sapiens	159-163
33178287-0	2020	Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/beta-Catenin Pathway.	Iron	0-4	catenin beta 1	Homo sapiens	124-136
33178287-8	2020	In conclusion, IO affects gene stability in higher-risk MDS patients and impairs MSCs by inducing ROS-related apoptosis and activating the Wnt/beta-catenin signaling pathway, which could be partially reversed by an antioxidant or an iron chelator.	Iron	233-237	catenin beta 1	Homo sapiens	143-155
33110194-5	2020	Growth and differentiation of cells induced by heme-albumin was dependent on heme-oxygenase 1 (HO-1) function and was accompanied with an increase of the intracellular labile iron pool (LIP).	Iron	175-179	heme oxygenase 1	Homo sapiens	95-99
32556142-8	2020	To overcome this issue, we postulated that some level of iron restriction (by targeting Tmprss6) would improve the splenomegaly while preserving the beneficial effects on RBC production mediated by EPO or Tfr2 deletion.	Iron	57-61	erythropoietin	Mus musculus	198-201
33096655-3	2020	Iron deposits are present in the core of Lewy bodies, and there are reports suggesting that divalent metal ions including Cu2+ and Fe2+ enhance the aggregation of alpha-Syn.	Iron	0-4	synuclein alpha	Homo sapiens	163-172
33096655-7	2020	Research over the past decade has shown that alpha-Syn has iron import functions with an ability to oxidize the Fe3+ form of iron to Fe2+ to facilitate its entry into cells.	Iron	59-63	synuclein alpha	Homo sapiens	45-54
33096655-7	2020	Research over the past decade has shown that alpha-Syn has iron import functions with an ability to oxidize the Fe3+ form of iron to Fe2+ to facilitate its entry into cells.	Iron	125-129	synuclein alpha	Homo sapiens	45-54
33096618-3	2020	Serum iron and glucose levels are subjected to hormonal regulation by hepcidin and insulin, respectively.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	70-78
33096618-4	2020	Hepcidin is a liver-derived peptide hormone that inactivates the iron exporter ferroportin in target cells, thereby limiting iron efflux to the bloodstream.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	0-8
33096618-4	2020	Hepcidin is a liver-derived peptide hormone that inactivates the iron exporter ferroportin in target cells, thereby limiting iron efflux to the bloodstream.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	0-8
33096672-6	2020	In particular, by using in vivo and in vitro models of fasting, we found that typical Nrf2-dependent genes, including those controlling iron (e.g., Ho-1) and glutathione (GSH) metabolism (e.g., Gcl, Gsr) are induced along with increased levels of the glutathione peroxidase 4 (Gpx4), a GSH-dependent antioxidant enzyme.	Iron	136-140	glutathione peroxidase 4	Homo sapiens	251-275
33096672-6	2020	In particular, by using in vivo and in vitro models of fasting, we found that typical Nrf2-dependent genes, including those controlling iron (e.g., Ho-1) and glutathione (GSH) metabolism (e.g., Gcl, Gsr) are induced along with increased levels of the glutathione peroxidase 4 (Gpx4), a GSH-dependent antioxidant enzyme.	Iron	136-140	glutathione peroxidase 4	Homo sapiens	277-281
33092142-5	2020	In neonates lacking HO1, functioning of renal molecular machinery responsible for iron reabsorption from the primary urine (megalin/cubilin complex) and its transfer to the blood (ferroportin) was either shifted in time or impaired, respectively.	Iron	82-86	low density lipoprotein receptor-related protein 2	Mus musculus	124-131
33069164-0	2020	Iron transport across the human placenta is regulated by hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	57-65
33069164-3	2020	Herein, we investigate the role of hepcidin, a master regulator of iron homeostasis, on regulation of iron transport across trophoblast cells.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	35-43
33069164-3	2020	Herein, we investigate the role of hepcidin, a master regulator of iron homeostasis, on regulation of iron transport across trophoblast cells.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	35-43
33069164-6	2020	RESULTS: Hepcidin treatment of Jeg-3 cells decreased the expression of ferroportin and transferrin receptor (TfR) and reduced the cellular export of iron.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	9-17
33069164-9	2020	CONCLUSIONS: Our data suggest that hepcidin plays an important role in the regulation of iron transport across the placenta, making it a critical link in movement of iron into fetal circulation.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	35-43
33069164-9	2020	CONCLUSIONS: Our data suggest that hepcidin plays an important role in the regulation of iron transport across the placenta, making it a critical link in movement of iron into fetal circulation.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	35-43
33069164-10	2020	IMPACT: Hepcidin has a direct impact on iron transport across the human placenta.This study provides the first evidence of direct regulation of iron efflux from human trophoblast cells by hepcidin.These data extend our understanding of iron transport across the maternal-fetal interface, a process critical for fetal health and development.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	8-16
33069164-10	2020	IMPACT: Hepcidin has a direct impact on iron transport across the human placenta.This study provides the first evidence of direct regulation of iron efflux from human trophoblast cells by hepcidin.These data extend our understanding of iron transport across the maternal-fetal interface, a process critical for fetal health and development.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	188-196
33069164-10	2020	IMPACT: Hepcidin has a direct impact on iron transport across the human placenta.This study provides the first evidence of direct regulation of iron efflux from human trophoblast cells by hepcidin.These data extend our understanding of iron transport across the maternal-fetal interface, a process critical for fetal health and development.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	8-16
33069164-10	2020	IMPACT: Hepcidin has a direct impact on iron transport across the human placenta.This study provides the first evidence of direct regulation of iron efflux from human trophoblast cells by hepcidin.These data extend our understanding of iron transport across the maternal-fetal interface, a process critical for fetal health and development.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	188-196
33069164-10	2020	IMPACT: Hepcidin has a direct impact on iron transport across the human placenta.This study provides the first evidence of direct regulation of iron efflux from human trophoblast cells by hepcidin.These data extend our understanding of iron transport across the maternal-fetal interface, a process critical for fetal health and development.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	8-16
33069164-10	2020	IMPACT: Hepcidin has a direct impact on iron transport across the human placenta.This study provides the first evidence of direct regulation of iron efflux from human trophoblast cells by hepcidin.These data extend our understanding of iron transport across the maternal-fetal interface, a process critical for fetal health and development.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	188-196
33123307-4	2020	Here, we showed that the cytotoxicity of iron overload in osteoblastic cells was mainly due to necrosis, as evidenced by the Hoechst 33258/PI staining, Annexin-V/PI staining, and transmission electronic microscopy.	Iron	41-45	annexin A5	Homo sapiens	152-161
33123307-5	2020	Furthermore, we revealed that iron overload-induced osteoblastic necrosis might be mediated via the RIPK1/RIPK3/MLKL necroptotic pathway.	Iron	30-34	receptor interacting serine/threonine kinase 1	Homo sapiens	100-105
32531582-5	2020	Non-metric multidimensional scaling and distance-based redundancy analysis revealed that microbial communities exhibited significant differentiation (R2 adjusted = 0.73, p = 0.0001) between mine tailings and Und over the different studied sites, which was strongly influenced by changes on physicochemical properties (pH, Corg and Nt contents, the predominance of small-sized particles of silt, and bulk density) and the presence of Se, Cr, Fe, and Ni, even at low concentrations.	Iron	441-443	collagen type XIV alpha 1 chain	Homo sapiens	208-211
33020528-7	2020	Livers, spleens, and kidneys contained increased iron in Pcsk9-/-, SCDbmt mice compared to Pcsk9+/+, SCDbmt mice consistent with greater hemolysis.	Iron	49-53	proprotein convertase subtilisin/kexin type 9	Mus musculus	57-62
32844200-0	2020	Iron supplementation in infants: a reflection on hepcidin and fractional iron absorption.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	49-57
30732902-10	2019	Post-RYGB, iron AUC0-24h showed a strong negative correlation with both hepcidin concentrations and TSAT (R=-0.51; P = 0.08 and R=-0.81; P = 0.001), respectively.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	72-80
30732902-14	2019	CONCLUSIONS: The iron AUC0-24h showed a negative correlation with the hepcidin concentration and TSAT of obese patients, in particular post-RYGB.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	70-78
32522525-5	2020	Unexpectedly, novel di-2-pyridylketone thiosemicarbazones that demonstrate marked anti-tumor activity, down-regulate c-MET through their ability to bind intracellular iron and via mechanisms including, down-regulation of MET mRNA, enhanced lysosomal processing and increased metalloprotease-mediated cleavage.	Iron	167-171	SAFB like transcription modulator	Homo sapiens	119-122
32735914-4	2020	To reconcile the apparent contradiction between the known physiological functions and predicted biochemical properties of Tsf1s, we purified and characterized the iron-binding properties of Drosophila melanogaster Tsf1 (DmTsf1), Manduca sexta Tsf1 (MsTsf1), and the amino-lobe of DmTsf1 (DmTsf1N).	Iron	163-167	serine/threonine kinase 16	Homo sapiens	214-218
32735914-8	2020	These findings will be critical for elucidating the mechanisms of Tsf1 function in iron sequestration and transport in insects.	Iron	83-87	serine/threonine kinase 16	Homo sapiens	66-70
32945814-0	2020	Tri-functional Fe-Zr bi-metal-organic frameworks enable high-performance phosphate ion ratiometric fluorescent detection.	Iron	15-17	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
31388672-5	2020	Previous studies showed that glutathione (GSH) is one such thiols, and that cellular gamma-glutamyltransferase (GGT) can efficiently potentiate GSH-dependent iron redox cycling and consequent oxidative stress.	Iron	158-162	gamma-glutamyltransferase light chain family member 3	Homo sapiens	85-110
31388672-5	2020	Previous studies showed that glutathione (GSH) is one such thiols, and that cellular gamma-glutamyltransferase (GGT) can efficiently potentiate GSH-dependent iron redox cycling and consequent oxidative stress.	Iron	158-162	gamma-glutamyltransferase light chain family member 3	Homo sapiens	112-115
33007983-11	2020	However, it demonstrated an effect on virulence through the production of pyoverdine with a dose-dependent manner by more than 7-fold when treated at a concentration of 128 microg mL-1, thus suggesting a link between di-CQA and iron sequestration.	Iron	228-232	L1 cell adhesion molecule	Mus musculus	180-184
33101032-6	2020	The current study suggested that icotinib-1,2,3-triazole derivatives could be used as potential inhibitors that preferentially bind to the ferrous form of IDO1 through the formation of coordinate bond with the haem iron.	Iron	215-219	indoleamine 2,3-dioxygenase 1	Homo sapiens	155-159
33062249-3	2020	Objectives: To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP.	Iron	88-92	ceruloplasmin	Homo sapiens	28-41
33062715-8	2020	ITK-SNAP was used to measure the susceptibility values reflecting the content of iron in the regions of interest (ROIs).	Iron	81-85	IL2 inducible T cell kinase	Homo sapiens	0-3
32968051-12	2020	Furthermore, HO-1 abrogation strongly augmented the cytotoxic effects of hemin in HCEC, revealing its pivotal function in colonocytes and highlighting the toxicity of free intracellular heme iron.	Iron	191-195	heme oxygenase 1	Homo sapiens	13-17
32968192-13	2020	These results indicate that the S-nitrosylation of parkin inhibits its E3 ubiquitin ligase activity for the ubiquitination of DMT1, which contributes to iron accumulation and degenerative process in PD.	Iron	153-157	solute carrier family 11 member 2	Homo sapiens	126-130
32915978-7	2020	Consistent with preclinical data, daily MMB treatment led to an acute and persistent decrease in blood hepcidin associated with increased iron availability and markers of erythropoiesis.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	103-111
32947823-3	2020	In general, iron precatalysts showed higher activities than their cobalt analogs; for example, 10.9 x 106 g(PE) mol-1 (Co) h-1 by Co4 and 17.0 x 106 g(PE) mol-1 (Fe) h-1 by Fe4.	Iron	12-16	complement C4A (Rodgers blood group)	Homo sapiens	130-133
32353494-2	2020	In this work, we prepared a gelatin methacrylate (GelMA)/oxidized hyaluronic acid (OHA)/galactosylated chitosan (Gal-CS)/Fe (III)@TA@IGF-2 200 (TA200) hydrogel loaded with insulin-like growth factor 2 (IGF-2) for regeneration of damaged hepatocytes.	Iron	121-123	insulin like growth factor 2	Homo sapiens	133-138
32353494-2	2020	In this work, we prepared a gelatin methacrylate (GelMA)/oxidized hyaluronic acid (OHA)/galactosylated chitosan (Gal-CS)/Fe (III)@TA@IGF-2 200 (TA200) hydrogel loaded with insulin-like growth factor 2 (IGF-2) for regeneration of damaged hepatocytes.	Iron	121-123	insulin like growth factor 2	Homo sapiens	172-200
32353494-2	2020	In this work, we prepared a gelatin methacrylate (GelMA)/oxidized hyaluronic acid (OHA)/galactosylated chitosan (Gal-CS)/Fe (III)@TA@IGF-2 200 (TA200) hydrogel loaded with insulin-like growth factor 2 (IGF-2) for regeneration of damaged hepatocytes.	Iron	121-123	insulin like growth factor 2	Homo sapiens	202-207
32473437-4	2020	Seasonal increase of S(-II) and Fe(II) concentrations in monsoon season suggests the co-occurrence of iron and sulfate reduction.	Iron	102-106	transcription elongation factor A1	Homo sapiens	21-26
32899732-1	2020	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into carbon monoxide (CO), iron, and biliverdin, which is rapidly metabolized to bilirubin.	Iron	85-89	heme oxygenase 1	Homo sapiens	0-16
32899732-1	2020	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into carbon monoxide (CO), iron, and biliverdin, which is rapidly metabolized to bilirubin.	Iron	85-89	heme oxygenase 1	Homo sapiens	18-22
32984038-1	2020	Background: Ferroptosis is a form of iron-dependent non-apoptotic cell death, with characteristics of loss of the activity of the lipid repair enzyme, glutathione (GSH) peroxidase 4 (GPX4), and accumulation of lethal reactive lipid oxygen species.	Iron	37-41	glutathione peroxidase 4	Mus musculus	183-187
32984336-6	2020	Yet we recently showed iron and manganese import at the OMM involves divalent metal transporter 1 (DMT1), an H+-coupled metal ion transporter.	Iron	23-27	solute carrier family 11 member 2	Homo sapiens	69-97
32984336-6	2020	Yet we recently showed iron and manganese import at the OMM involves divalent metal transporter 1 (DMT1), an H+-coupled metal ion transporter.	Iron	23-27	solute carrier family 11 member 2	Homo sapiens	99-103
32984336-9	2020	Furthermore, the environmental toxicant cadmium selectively damages kidney mitochondria by "ionic mimicry" utilizing iron and calcium transporters, such as OMM DMT1 or IMM calcium uniporter, and by disrupting the electron transport chain.	Iron	20-24	solute carrier family 11 member 2	Homo sapiens	160-164
32510613-0	2020	Genetic Screens Reveal CCDC115 as a Modulator of Erythroid Iron and Heme Trafficking.	Iron	59-63	coiled-coil domain containing 115	Homo sapiens	23-30
32565401-0	2020	Sequential recruitment of the mRNA decay machinery to the iron-regulated protein Cth2 in Saccharomyces cerevisiae.	Iron	58-62	Tis11p	Saccharomyces cerevisiae S288C	81-85
32565401-2	2020	In the model eukaryote Saccharomyces cerevisiae, a conserved mRNA-binding protein, known as Cth2, modulates the metabolic response to iron deficiency.	Iron	134-138	Tis11p	Saccharomyces cerevisiae S288C	92-96
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	165-169	hemojuvelin BMP co-receptor	Homo sapiens	56-59
30542109-0	2019	Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation.	Iron	72-76	bone morphogenetic protein 6	Mus musculus	0-28
30542109-0	2019	Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation.	Iron	72-76	bone morphogenetic protein 6	Mus musculus	30-35
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	130-138
30542109-11	2019	Furthermore, BMP-6 KO mice displayed elevated iron levels and an aggravated CS-induced inflammatory response.	Iron	46-50	bone morphogenetic protein 6	Mus musculus	13-18
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	hepcidin antimicrobial peptide	Homo sapiens	130-138
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	217-221	hepcidin antimicrobial peptide	Homo sapiens	130-138
32585319-7	2020	This review will discuss recent insights into the role of the BMP-SMAD pathway in regulating hepcidin to control systemic iron homeostasis.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	93-101
32674118-2	2020	Hepcidin, a key regulator of iron homeostasis, is reduced in iron deficiency (ID) and increased in iron overload.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
32674118-2	2020	Hepcidin, a key regulator of iron homeostasis, is reduced in iron deficiency (ID) and increased in iron overload.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
32754933-0	2020	Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107.	Iron	0-4	synuclein, alpha	Mus musculus	31-46
32754933-0	2020	Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107.	Iron	0-4	synuclein, alpha	Mus musculus	131-146
32754933-0	2020	Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107.	Iron	98-102	synuclein, alpha	Mus musculus	31-46
32754933-0	2020	Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107.	Iron	98-102	synuclein, alpha	Mus musculus	131-146
32754933-2	2020	It has been previously shown that iron promotes alpha-synuclein aggregation, and alpha-synuclein dysfunction impairs iron metabolism.	Iron	34-38	synuclein, alpha	Mus musculus	48-63
32754933-4	2020	have shown that the H63D variant of the homeostatic iron regulator (HFE) facilitates alpha-syn degradation via REDD1-mediated autophagy.	Iron	52-56	synuclein, alpha	Mus musculus	85-94
32558275-3	2020	In this respect, we showed that limiting iron (Fe) uptake makes bacteria much more susceptible to Cu2 + or Cd2+ poisoning.	Iron	41-45	CD2 molecule	Homo sapiens	107-110
32558275-3	2020	In this respect, we showed that limiting iron (Fe) uptake makes bacteria much more susceptible to Cu2 + or Cd2+ poisoning.	Iron	47-49	CD2 molecule	Homo sapiens	107-110
32588561-1	2020	BACKGROUND: Hepcidin and hemochromatosis (HFE) are iron regulatory proteins that are encoded by HAMP and HFE genes.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	12-20
32588561-1	2020	BACKGROUND: Hepcidin and hemochromatosis (HFE) are iron regulatory proteins that are encoded by HAMP and HFE genes.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	96-100
32588561-2	2020	Mutation in either HAMP gene or HFE gene causes Hepcidin protein deficiency that can lead to iron overload in beta thalassemia patients.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	19-23
32588561-2	2020	Mutation in either HAMP gene or HFE gene causes Hepcidin protein deficiency that can lead to iron overload in beta thalassemia patients.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	48-56
32882879-2	2020	Transferrin (TF), an endogenous iron chelator, was proposed as a therapeutic candidate.	Iron	32-36	coagulation factor III, tissue factor	Homo sapiens	13-15
33184558-0	2020	Reductive Degradation of CCl4 by Sulfidized Fe and Pd-Fe Nanoparticles: Kinetics, Longevity, and Morphology Aspects.	Iron	44-46	C-C motif chemokine ligand 4	Homo sapiens	25-29
32696774-5	2020	Here, we found that the level of adsorbed heat shock protein 90 kDa alpha class B member 1 (Hsp90ab1) by the denatured protein in iron-cobalt-nickel alloy NPs (FeCoNi NPs) and iron oxide NPs (Fe3O4 NPs) was correlated with circular dichroism (CD) analysis and 1-anilinonaphthalene-8-sulfonate (ANS) analysis.	Iron	130-134	heat shock protein 90 alpha family class B member 1	Homo sapiens	92-100
32848555-3	2020	Furthermore, the metabolism of iron, lipids, and amino acids plays a significant regulatory role in ferroptosis, which can be reversed by glutathione peroxidase 4 and ferroptosis suppressor protein 1.	Iron	31-35	glutathione peroxidase 4	Homo sapiens	138-162
32953980-5	2020	Using western blots and reverse transcriptase polymerase chain reactions, we found that irisin can further exacerbate erastin-induced upregulation in free iron, lipid ROS levels, and glutathione depletion, relative to cells treated with erastin only.	Iron	155-159	fibronectin type III domain containing 5	Homo sapiens	88-94
32953980-7	2020	Furthermore, irisin modulation of ferroptosis was associated with the expression changes in molecules important for ROS metabolism, iron metabolism, and the cysteine/glutamate antiporter system (system Xc -).	Iron	132-136	fibronectin type III domain containing 5	Homo sapiens	13-19
32628455-3	2020	In anoxic environments, the adsorbed p-NP on goethite was sharply released in the presence of S(-II) at two different concentrations (denoted as G1 and G2, respectively) due to lower affinity of p-NP on =Fe-SH than =Fe-OH.	Iron	204-206	transcription elongation factor A1	Homo sapiens	94-100
32767480-0	2020	Impaired proteasome activity and neurodegeneration with brain iron accumulation in FBXO7 defect.	Iron	62-66	F-box protein 7	Homo sapiens	83-88
32767480-4	2020	RESULTS: A novel homozygous c.368C>G (p.S123*) FBXO7 mutation was identified in a child with spastic paraplegia, epilepsy, cerebellar degeneration, levodopa nonresponsive parkinsonism, and brain iron deposition.	Iron	195-199	F-box protein 7	Homo sapiens	47-52
32473314-8	2020	Moreover, alkaline phosphatase expression and iron accumulation were reduced in dental epithelial cells in Smad4 cKO mice.	Iron	46-50	SMAD family member 4	Mus musculus	107-112
31778583-1	2020	Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin.	Iron	69-73	bone morphogenetic protein 6	Mus musculus	37-41
32708433-12	2020	It identifies a unique mechanism of HIF-2alpha over-activation, which is mediated by iron imbalance of the iron-PHD coupling that modulates tumor angiogenesis.	Iron	85-89	endothelial PAS domain protein 1	Homo sapiens	36-46
30550860-2	2019	Identification of new interacting partners and different sub-cellular localizations of Tau in recent years led to the discovery of novel physiological functions in regulation of neuronal activity, neurogenesis, long-term depression, iron export and genomic integrity.	Iron	233-237	microtubule associated protein tau	Homo sapiens	87-90
32668256-6	2020	We identify that ebselen, a selective divalent metal transporter 1 (DMT1) inhibitor and antioxidant, could prevent the observed iron overload phenotypes, supporting the role of DMT1 in iron uptake into the human myocardium.	Iron	185-189	solute carrier family 11 member 2	Homo sapiens	177-181
30554085-1	2019	In Parkinson"s disease (PD), iron accumulation in the substantia nigra (SN) exacerbates oxidative stress and alpha-synuclein aggregation, leading to neuronal death.	Iron	29-33	synuclein alpha	Homo sapiens	109-124
32760266-5	2020	Iron has been shown to promote aggregation and pathogenicity of the characteristic aberrant proteins, beta-amyloid, tau, alpha-synuclein, and TDP43, in these diseases.	Iron	0-4	synuclein alpha	Homo sapiens	121-136
30762062-1	2019	Previous studies have led to opposing hypotheses about the requirement of intermolecular disulfide exchange in the binding of the iron regulatory peptide hepcidin to its receptor ferroportin.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	154-162
32661253-3	2020	Here we find that WS2 and MoS2 nanosheets induce an iron-dependent cell death, ferroptosis in epithelial (BEAS-2B) and macrophage (THP-1) cells, evidenced by the suppression of glutathione peroxidase 4 (GPX4), oxygen radical generation and lipid peroxidation.	Iron	52-56	glutathione peroxidase 4	Homo sapiens	177-201
30590010-5	2019	In addition, iron directly interacts with alpha-synuclein in Lewy bodies, which are primarily digested through the autophagy-lysosome pathway.	Iron	13-17	synuclein alpha	Homo sapiens	42-57
32661253-3	2020	Here we find that WS2 and MoS2 nanosheets induce an iron-dependent cell death, ferroptosis in epithelial (BEAS-2B) and macrophage (THP-1) cells, evidenced by the suppression of glutathione peroxidase 4 (GPX4), oxygen radical generation and lipid peroxidation.	Iron	52-56	glutathione peroxidase 4	Homo sapiens	203-207
32733248-2	2020	NE stimulates epithelial toll like receptors (TLR) resulting in cytokine upregulation and release, upregulates MUC5AC, a major airway mucin, degrades both phagocytic receptors and opsonins resulting in both neutrophil and macrophage phagocytic failure, generates oxidative stress via extracellular generation and uptake of heme free iron, and activates other proteases.	Iron	333-337	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	111-117
30556289-1	2019	The syn and anti isomers of [FeIV (O)(TMC)]2+ (TMC=tetramethylcyclam) represent the first isolated pair of synthetic non-heme oxoiron(IV) complexes with identical ligand topology, differing only in the position of the oxo unit bound to the iron center.	Iron	129-133	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	38-41
30556289-1	2019	The syn and anti isomers of [FeIV (O)(TMC)]2+ (TMC=tetramethylcyclam) represent the first isolated pair of synthetic non-heme oxoiron(IV) complexes with identical ligand topology, differing only in the position of the oxo unit bound to the iron center.	Iron	129-133	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	47-50
32155549-8	2020	XPS analysis showed that both Fe(II) and S(-II) species on the FeS surface were involved in the reductive transformation of TCEP.	Iron	63-66	transcription elongation factor A1	Homo sapiens	41-46
30728365-8	2019	We hypothesize that decreased expression of miR-148a in HCC may elevate transferrin-bound iron uptake, increasing cellular iron levels and cell proliferation.	Iron	90-94	microRNA 148a	Homo sapiens	44-52
30587002-11	2019	THP1 human macrophages treated with an iron chelator were used to model hepcidin deficiency in vitro.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	72-80
32129080-6	2020	The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2.	Iron	170-174	coproporphyrinogen oxidase	Mus musculus	65-68
32718192-1	2020	Patients with beta-thalassemia major (beta-TM) show ineffective erythropoiesis and iron overload, which is the leading cause of mortality and organ injury.	Iron	83-87	ATM serine/threonine kinase	Homo sapiens	38-45
30605865-0	2019	Curcumin"s antiepileptic effect, and alterations in Nav1.1 and Nav1.6 expression in iron-induced epilepsy.	Iron	84-88	neuron navigator 1	Rattus norvegicus	52-56
30605865-0	2019	Curcumin"s antiepileptic effect, and alterations in Nav1.1 and Nav1.6 expression in iron-induced epilepsy.	Iron	84-88	neuron navigator 1	Rattus norvegicus	63-67
32304700-5	2020	Here, we describe the identification, maturation, characterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a native receptor and BBB transporter for the iron chaperone transferrin.	Iron	185-189	cut-like homeobox 1	Mus musculus	89-92
30527495-3	2019	Accumulating evidence showing a link between carcinogenesis and increased expression of iron import proteins and intracellular iron prompted us to investigate a role of divalent metal-ion transporter-1 (DMT1) that binds and regulates a variety of divalent metals in HCC.	Iron	88-92	solute carrier family 11 member 2	Homo sapiens	203-207
30527495-3	2019	Accumulating evidence showing a link between carcinogenesis and increased expression of iron import proteins and intracellular iron prompted us to investigate a role of divalent metal-ion transporter-1 (DMT1) that binds and regulates a variety of divalent metals in HCC.	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	203-207
32429669-2	2020	We show here that dimeric cluster-bridged GLRX3 transfers its [2Fe-2S]2+ clusters to the human P-loop NTPase NUBP1, an essential early component of the cytosolic iron-sulfur assembly (CIA) machinery.	Iron	162-166	glutaredoxin 3	Homo sapiens	42-47
30580021-1	2019	BACKGROUND: Heme oxygenase-1 (HO-1), a cellular stress protein, serves a vital metabolic function as the rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), iron, and biliverdin (BR).	Iron	187-191	heme oxygenase 1	Homo sapiens	12-28
30580021-1	2019	BACKGROUND: Heme oxygenase-1 (HO-1), a cellular stress protein, serves a vital metabolic function as the rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), iron, and biliverdin (BR).	Iron	187-191	heme oxygenase 1	Homo sapiens	30-34
32429669-2	2020	We show here that dimeric cluster-bridged GLRX3 transfers its [2Fe-2S]2+ clusters to the human P-loop NTPase NUBP1, an essential early component of the cytosolic iron-sulfur assembly (CIA) machinery.	Iron	162-166	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	109-114
32542039-0	2020	Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism.	Iron	35-39	BRCA1 interacting helicase 1	Homo sapiens	57-62
32545266-3	2020	Here, we examined the role of SMILE in regulating iron metabolism by inflammatory signals.	Iron	50-54	CREB/ATF bZIP transcription factor	Mus musculus	30-35
29679389-2	2019	Natural resistance-associated macrophage protein-1 (Nramp1) was previously shown to contribute to the degradation of extracellular alpha-synuclein in microglia under conditions of iron overload.	Iron	180-184	synuclein alpha	Homo sapiens	131-146
30593976-3	2019	Given the non-trivial side effects of classical iron chelators, lactoferrin (Lf), a multifunctional iron-binding globular glycoprotein, was screened to identify novel neuroprotective pathways against dopaminergic neuronal impairment.	Iron	100-104	lactotransferrin	Mus musculus	64-75
30660959-6	2019	Here, we demonstrate that upon oxidative stress Hsp90 loses its function in a highly specific non-enzymatic iron-catalyzed oxidation event and its breakdown product, a cleaved form of Hsp90 (Hsp90cl), acquires a new function in mediating the accumulation of actin aggregates.	Iron	108-112	heat shock protein 90 alpha family class A member 1	Homo sapiens	48-53
30660959-6	2019	Here, we demonstrate that upon oxidative stress Hsp90 loses its function in a highly specific non-enzymatic iron-catalyzed oxidation event and its breakdown product, a cleaved form of Hsp90 (Hsp90cl), acquires a new function in mediating the accumulation of actin aggregates.	Iron	108-112	heat shock protein 90 alpha family class A member 1	Homo sapiens	184-189
30660959-6	2019	Here, we demonstrate that upon oxidative stress Hsp90 loses its function in a highly specific non-enzymatic iron-catalyzed oxidation event and its breakdown product, a cleaved form of Hsp90 (Hsp90cl), acquires a new function in mediating the accumulation of actin aggregates.	Iron	108-112	heat shock protein 90 alpha family class A member 1	Homo sapiens	191-198
32545266-9	2020	These results reveal a previously unrecognized role of EGCG-inducible SMILE in the IL-6-dependent transcriptional regulation of iron metabolism.	Iron	128-132	CREB/ATF bZIP transcription factor	Mus musculus	70-75
32511251-19	2020	Hepcidin is a useful biomarker for predicting iron requirement in cancer patients.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
30696910-0	2019	Imaging endogenous macrophage iron deposits reveals a metabolic biomarker of polarized tumor macrophage infiltration and response to CSF1R breast cancer immunotherapy.	Iron	30-34	colony stimulating factor 1	Homo sapiens	133-137
30696910-4	2019	Macrophage-targeted inhibition of the colony stimulating factor 1 receptor (CSF1R) by immunotherapy was confirmed to inhibit macrophage accumulation and slow mammary tumor growth in mouse models while also reducing hemosiderin iron-laden TAM accumulation as measured by both iron histology and in vivo iron MRI (FeMRI).	Iron	227-231	colony stimulating factor 1 receptor	Mus musculus	38-74
30696910-4	2019	Macrophage-targeted inhibition of the colony stimulating factor 1 receptor (CSF1R) by immunotherapy was confirmed to inhibit macrophage accumulation and slow mammary tumor growth in mouse models while also reducing hemosiderin iron-laden TAM accumulation as measured by both iron histology and in vivo iron MRI (FeMRI).	Iron	227-231	colony stimulating factor 1 receptor	Mus musculus	76-81
30696910-4	2019	Macrophage-targeted inhibition of the colony stimulating factor 1 receptor (CSF1R) by immunotherapy was confirmed to inhibit macrophage accumulation and slow mammary tumor growth in mouse models while also reducing hemosiderin iron-laden TAM accumulation as measured by both iron histology and in vivo iron MRI (FeMRI).	Iron	275-279	colony stimulating factor 1 receptor	Mus musculus	38-74
33479694-2	2020	SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	0-7
30696910-4	2019	Macrophage-targeted inhibition of the colony stimulating factor 1 receptor (CSF1R) by immunotherapy was confirmed to inhibit macrophage accumulation and slow mammary tumor growth in mouse models while also reducing hemosiderin iron-laden TAM accumulation as measured by both iron histology and in vivo iron MRI (FeMRI).	Iron	275-279	colony stimulating factor 1 receptor	Mus musculus	76-81
30696910-4	2019	Macrophage-targeted inhibition of the colony stimulating factor 1 receptor (CSF1R) by immunotherapy was confirmed to inhibit macrophage accumulation and slow mammary tumor growth in mouse models while also reducing hemosiderin iron-laden TAM accumulation as measured by both iron histology and in vivo iron MRI (FeMRI).	Iron	275-279	colony stimulating factor 1 receptor	Mus musculus	38-74
30696910-4	2019	Macrophage-targeted inhibition of the colony stimulating factor 1 receptor (CSF1R) by immunotherapy was confirmed to inhibit macrophage accumulation and slow mammary tumor growth in mouse models while also reducing hemosiderin iron-laden TAM accumulation as measured by both iron histology and in vivo iron MRI (FeMRI).	Iron	275-279	colony stimulating factor 1 receptor	Mus musculus	76-81
33479694-2	2020	SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	9-14
30679587-0	2019	The bacterial MrpORP is a novel Mrp/NBP35 protein involved in iron-sulfur biogenesis.	Iron	62-66	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	36-41
33479694-2	2020	SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis.	Iron	90-94	solute carrier family 11 member 2	Homo sapiens	0-7
30679587-3	2019	Mrp/NBP35 ATP-binding proteins are a subclass of the soluble P-loop containing nucleoside triphosphate hydrolase superfamily (P-loop NTPase) known to bind and transfer Fe-S clusters in vitro.	Iron	168-172	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	4-9
33479694-2	2020	SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis.	Iron	90-94	solute carrier family 11 member 2	Homo sapiens	9-14
33479694-3	2020	Here we report a micromolar (IC50 = 1.1 muM) pyrazolyl-pyrimidone inhibitor of radiolabeled iron uptake in hDMT1 overexpressing HEK293 cells acting by a non-competitive mechanism, which however does not affect the electrophysiological properties of the transporter.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	107-112
32278200-0	2020	Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	89-97
31496915-0	2019	The Importance of RET-He in the Diagnosis of Iron Deficiency and Iron Deficiency Anemia and the Evaluation of Response to Oral Iron Therapy.	Iron	45-49	ret proto-oncogene	Homo sapiens	18-21
32278200-6	2020	Further mechanistic research confirmed iron overload is caused by reactive oxygen species (ROS)-driven hepcidin disorder in hepatic cells, and the increase of hepcidin is regulated by the translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	103-111
30670944-1	2018	Ceruloplasmin (Cp) is a ferroxidase that also plays a role in iron efflux from cells.	Iron	62-66	ceruloplasmin	Mus musculus	0-13
30670944-1	2018	Ceruloplasmin (Cp) is a ferroxidase that also plays a role in iron efflux from cells.	Iron	62-66	ceruloplasmin	Mus musculus	24-35
32221605-2	2020	Obese women may be at risk for poor iron status in pregnancy due to proinflammatory-driven overexpression of hepcidin leading to decreased iron bioavailability.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	109-117
30401704-3	2019	Adaptation to iron deficiency at the tissue level is controlled by iron regulatory proteins to increase iron uptake and retention; at the systemic level, suppression of the iron hormone hepcidin increases iron release to plasma by absorptive enterocytes and recycling macrophages.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	186-194
30401704-7	2019	Ongoing efforts aim at optimizing iron salts-based therapy by protocols of administration based on the physiology of hepcidin control and reducing the common adverse effects of oral iron.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	117-125
30401705-4	2019	Inflammation-inducible cytokines and the master regulator of iron homeostasis, hepcidin, block intestinal iron absorption and cause iron retention in reticuloendothelial cells, resulting in iron-restricted erythropoiesis.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	79-87
30401705-4	2019	Inflammation-inducible cytokines and the master regulator of iron homeostasis, hepcidin, block intestinal iron absorption and cause iron retention in reticuloendothelial cells, resulting in iron-restricted erythropoiesis.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	79-87
30401705-4	2019	Inflammation-inducible cytokines and the master regulator of iron homeostasis, hepcidin, block intestinal iron absorption and cause iron retention in reticuloendothelial cells, resulting in iron-restricted erythropoiesis.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	79-87
32221605-2	2020	Obese women may be at risk for poor iron status in pregnancy due to proinflammatory-driven overexpression of hepcidin leading to decreased iron bioavailability.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	109-117
30401705-4	2019	Inflammation-inducible cytokines and the master regulator of iron homeostasis, hepcidin, block intestinal iron absorption and cause iron retention in reticuloendothelial cells, resulting in iron-restricted erythropoiesis.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	79-87
30401708-1	2019	The liver orchestrates systemic iron balance by producing and secreting hepcidin.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	72-80
31446620-9	2020	Ccm1+/-Msh2-/- (n=68) and Ccm3+/-Trp53-/- (n=71) mice treated with BA-1049 or placebo showed a significant dose-dependent reduction in lesion volume after treatment with BA-1049, and a reduction in hemorrhage (iron deposition) near lesions at all doses.	Iron	210-214	KRIT1, ankyrin repeat containing	Mus musculus	0-4
30401708-2	2019	Known as the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control iron entry into the bloodstream from dietary sources, iron recycling macrophages, and body stores.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	27-35
30401708-2	2019	Known as the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control iron entry into the bloodstream from dietary sources, iron recycling macrophages, and body stores.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	27-35
30401708-2	2019	Known as the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control iron entry into the bloodstream from dietary sources, iron recycling macrophages, and body stores.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	27-35
30401708-2	2019	Known as the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control iron entry into the bloodstream from dietary sources, iron recycling macrophages, and body stores.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	27-35
30401708-3	2019	Under physiologic conditions, hepcidin production is reduced by iron deficiency and erythropoietic drive to increase the iron supply when needed to support red blood cell production and other essential functions.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	30-38
30401708-4	2019	Conversely, hepcidin production is induced by iron loading and inflammation to prevent the toxicity of iron excess and limit its availability to pathogens.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	12-20
30401708-4	2019	Conversely, hepcidin production is induced by iron loading and inflammation to prevent the toxicity of iron excess and limit its availability to pathogens.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	12-20
32486516-5	2020	Conversely, PAD and POL meat was instrumentally tougher and richer in haem iron compared to the Hybrid.	Iron	75-79	endogenous retrovirus group K member 11 Pol protein	Gallus gallus	20-23
30401708-6	2019	Moreover, excess hepcidin suppression in the setting of ineffective erythropoiesis contributes to iron-loading anemias such as beta-thalassemia, whereas excess hepcidin induction contributes to iron-restricted erythropoiesis and anemia in chronic inflammatory diseases.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	17-25
30401708-6	2019	Moreover, excess hepcidin suppression in the setting of ineffective erythropoiesis contributes to iron-loading anemias such as beta-thalassemia, whereas excess hepcidin induction contributes to iron-restricted erythropoiesis and anemia in chronic inflammatory diseases.	Iron	194-198	hepcidin antimicrobial peptide	Homo sapiens	160-168
32486402-0	2020	Preparation of High-Nitrogen Ductile Iron by Injecting Nitrogen Gas in Molten Iron.	Iron	37-41	gastrin	Homo sapiens	64-67
30530987-0	2019	At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2alpha.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	46-54
30530987-0	2019	At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2alpha.	Iron	32-36	endothelial PAS domain protein 1	Homo sapiens	66-76
32486402-0	2020	Preparation of High-Nitrogen Ductile Iron by Injecting Nitrogen Gas in Molten Iron.	Iron	78-82	gastrin	Homo sapiens	64-67
30530987-1	2019	Hepcidin is the master regulator of iron metabolism.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
32486402-1	2020	High-nitrogen ductile iron (DI) was prepared by a new method of injecting nitrogen gas into molten iron and nodularizing treatment.	Iron	22-26	gastrin	Homo sapiens	83-86
30530987-2	2019	It plays a key role in the regulation of iron transport across the duodenal epithelium, which in turn is dependent on the oxygen-regulated transcription factor hypoxia-inducible factor 2alpha (HIF-2alpha).	Iron	41-45	endothelial PAS domain protein 1	Homo sapiens	160-191
30530987-2	2019	It plays a key role in the regulation of iron transport across the duodenal epithelium, which in turn is dependent on the oxygen-regulated transcription factor hypoxia-inducible factor 2alpha (HIF-2alpha).	Iron	41-45	endothelial PAS domain protein 1	Homo sapiens	193-203
32481481-7	2020	Relating to the molecular mechanism in Iron Deficiency Anemia (IDA), hepcidin has a key role in iron homeostasis.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	69-77
30530987-3	2019	In this issue of the JCI, Schwartz and colleagues show that duodenal HIF-2alpha is itself regulated by hepcidin, thereby indicating that this transcription factor is not only regulated by oxygen, but also by iron.	Iron	208-212	endothelial PAS domain protein 1	Homo sapiens	69-79
30530987-3	2019	In this issue of the JCI, Schwartz and colleagues show that duodenal HIF-2alpha is itself regulated by hepcidin, thereby indicating that this transcription factor is not only regulated by oxygen, but also by iron.	Iron	208-212	hepcidin antimicrobial peptide	Homo sapiens	103-111
30530987-4	2019	This work indicates that the crosstalk between liver hepcidin and intestinal HIF-2alpha plays an important role during iron overload, systemic iron deficiency, and anemia.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	53-61
30530987-4	2019	This work indicates that the crosstalk between liver hepcidin and intestinal HIF-2alpha plays an important role during iron overload, systemic iron deficiency, and anemia.	Iron	119-123	endothelial PAS domain protein 1	Homo sapiens	77-87
31456205-5	2019	Iron is believed to modulate alpha-synuclein synthesis, post-translational modification, and aggregation.	Iron	0-4	synuclein alpha	Homo sapiens	29-44
31456206-4	2019	Iron metabolism mainly depends on iron regulatory proteins including ferritin, transferrin and transferrin receptor, hepcidin, ferroportin, lactoferrin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	117-125
31456207-6	2019	For example, hepcidin has recently been recognized as the principal regulator of systemic iron homeostasis and a bridge between inflammation and iron regulation.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	13-21
32455741-4	2020	FTMT is an iron-sequestering protein primarily expressed in metabolically active cells and tissues with high oxygen demand, including retina.	Iron	11-15	ferritin mitochondrial	Homo sapiens	0-4
29666474-2	2019	The human iron-sulfur binding protein NAF-1/CISD2 binds to Bcl-2 and its disruption in cells leads to an increase in apoptosis.	Iron	10-14	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	38-43
32432042-3	2020	Here, we demonstrate that the alteration of iron homeostasis and the consequent increase of redox metabolism, mediated by the stable knock down of ferritin heavy chain (FtH), enhances the expression of CXCR4 in K562 erythroleukemia cells, thus promoting CXCL12-mediated motility.	Iron	44-48	ferritin heavy chain 1	Homo sapiens	147-167
30343320-4	2019	NAFLD progression seems to involve the occurrence of "parallel, multiple-hit" injuries, such as oxidative stress-induced mitochondrial dysfunction, endoplasmic reticulum stress, endotoxin-induced, TLR4-dependent release of inflammatory cytokines, and iron overload, among many others.	Iron	251-255	toll like receptor 4	Homo sapiens	197-201
32432042-3	2020	Here, we demonstrate that the alteration of iron homeostasis and the consequent increase of redox metabolism, mediated by the stable knock down of ferritin heavy chain (FtH), enhances the expression of CXCR4 in K562 erythroleukemia cells, thus promoting CXCL12-mediated motility.	Iron	44-48	ferritin heavy chain 1	Homo sapiens	169-172
32432042-11	2020	The effects of FtH dysregulation on CXCR4/CXCL12-mediated K562 cell motility extend the meaning of iron homeostasis in the leukemia cell microenvironment.	Iron	99-103	ferritin heavy chain 1	Homo sapiens	15-18
32019729-5	2020	Gaining Hif-2a acts through a different mechanism by restoring iron homeostatic gene expression in BPNT1 deficient mouse intestinal organoids.	Iron	63-67	endothelial PAS domain protein 1	Mus musculus	8-14
29737252-3	2019	A growing body of evidence has demonstrated that CP is an essential protein in the body with multiple functions such as regulating the homeostasis of copper and iron ions, ferroxidase activity, oxidizing organic amines, and preventing the formation of free radicals.	Iron	161-165	ceruloplasmin	Homo sapiens	49-51
29737252-5	2019	The fact that patients with genetic disorder aceruloplasminemia do not suffer from tissue copper deficiency, but rather from disruptions in iron metabolism shows essential roles of CP in iron metabolism rather than copper.	Iron	140-144	ceruloplasmin	Homo sapiens	181-183
32088260-1	2020	Hepcidin peptide is crucial in the regulation of systemic iron availability controlling its uptake from the diet and its release from the body storage tissues.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
29737252-5	2019	The fact that patients with genetic disorder aceruloplasminemia do not suffer from tissue copper deficiency, but rather from disruptions in iron metabolism shows essential roles of CP in iron metabolism rather than copper.	Iron	187-191	ceruloplasmin	Homo sapiens	181-183
32088260-2	2020	Hepcidin dysregulation causes different human disorders ranging from iron overload (e.g. hemochromatosis) to iron deficiency (e.g. anemia).	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
32006543-1	2020	OBJECTIVE: Heme oxygenase-1 (HO-1) degrades heme to CO, iron, and biliverdin/bilirubin.	Iron	56-60	heme oxygenase 1	Homo sapiens	11-27
30915867-8	2019	Our study indicated that hepcidin might be an important parameter for monitoring the iron metabolism and oxidative status of Hb H disease patients.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	25-33
32006543-1	2020	OBJECTIVE: Heme oxygenase-1 (HO-1) degrades heme to CO, iron, and biliverdin/bilirubin.	Iron	56-60	heme oxygenase 1	Homo sapiens	29-33
32014518-3	2020	Iron metabolism in the body is closely regulated by hepcidin, a short peptide produced by the liver.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	52-60
30417276-0	2019	The basic helix-loop-helix transcription factor, bHLH11 functions in the iron-uptake system in Arabidopsis thaliana.	Iron	73-77	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	49-55
30417276-5	2019	In the present study, we characterized bHLH11 as a negative regulator of Fe homeostasis.	Iron	73-75	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	39-45
30417276-9	2019	These results suggest that the transcriptional repressor bHLH11 functions as a negative regulator of FIT-dependent Fe uptake and modulates Fe levels in Arabidopsis plants.	Iron	115-117	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	57-63
30417276-9	2019	These results suggest that the transcriptional repressor bHLH11 functions as a negative regulator of FIT-dependent Fe uptake and modulates Fe levels in Arabidopsis plants.	Iron	139-141	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	57-63
31887240-4	2020	The concentrations of Fe in the emitted PM1 were found to be higher when cast-iron pan (8.49+-3.35 microg/m3 ) was utilized compared to Teflon (8.05+-2.27 microg/m3 ) and granitium (7.45+-1.38 microg/m3 ).	Iron	22-24	late embryogenesis abundant group 4 protein PM1	Glycine max	40-43
31309499-3	2019	In this assay, siderophores scavenge iron from an Fe-CAS-hexadecyltrimethylammonium bromide complex, and subsequent release of the CAS dye results in a color change from blue to orange.	Iron	37-41	chromosome segregation 1 like	Homo sapiens	53-56
31309499-3	2019	In this assay, siderophores scavenge iron from an Fe-CAS-hexadecyltrimethylammonium bromide complex, and subsequent release of the CAS dye results in a color change from blue to orange.	Iron	37-41	chromosome segregation 1 like	Homo sapiens	131-134
31887240-4	2020	The concentrations of Fe in the emitted PM1 were found to be higher when cast-iron pan (8.49+-3.35 microg/m3 ) was utilized compared to Teflon (8.05+-2.27 microg/m3 ) and granitium (7.45+-1.38 microg/m3 ).	Iron	78-82	late embryogenesis abundant group 4 protein PM1	Glycine max	40-43
32610864-0	2020	A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	131-139
30342981-5	2019	Results showed that iron could induce a decrease in the mitochondrial transmembrane potential and result in alpha-synuclein aggregation in the SK-N-SH cells, which could be restored by RA pretreatment.	Iron	20-24	synuclein alpha	Homo sapiens	108-123
30342981-6	2019	Further results showed RA pretreatment could inhibit iron-induced alpha-synuclein aggregation by up-regulating hemeoxygenase-1 (HO-1).	Iron	53-57	synuclein alpha	Homo sapiens	66-81
30342981-7	2019	In addition, iron could increase the mRNA levels of alpha-synuclein via iron responsive element/iron regulatory protein (IRE/IRP) system.	Iron	13-17	synuclein alpha	Homo sapiens	52-67
30342981-7	2019	In addition, iron could increase the mRNA levels of alpha-synuclein via iron responsive element/iron regulatory protein (IRE/IRP) system.	Iron	72-76	synuclein alpha	Homo sapiens	52-67
30342981-9	2019	These results indicated that RA protected against iron-induced alpha-synuclein aggregation by up-regulating HO-1 and inhibiting alpha-synuclein expression.	Iron	50-54	synuclein alpha	Homo sapiens	63-78
30342981-9	2019	These results indicated that RA protected against iron-induced alpha-synuclein aggregation by up-regulating HO-1 and inhibiting alpha-synuclein expression.	Iron	50-54	synuclein alpha	Homo sapiens	128-143
32296847-8	2020	Thus, these findings indicate that iron-binding protein LCN2-mediated oxidative stress promotes neurodegeneration in ob/ob mice.	Iron	35-39	leptin	Mus musculus	117-119
30333149-3	2019	Subsequently, a basic helix-loop-helix transcription factor, MdbHLH104 (a homolog of Arabidopsis bHLH104 in apple), which acts as a key component in regulating PM H+-ATPase-mediated rhizosphere acidification and Fe uptake in apples (Malus domestica), was identified as a direct target of MdSIZ1.	Iron	212-214	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	63-70
32296847-8	2020	Thus, these findings indicate that iron-binding protein LCN2-mediated oxidative stress promotes neurodegeneration in ob/ob mice.	Iron	35-39	leptin	Mus musculus	120-122
32318880-5	2020	Perhaps in the early diseased state, overexpression or mutation of alpha-synuclein/ferrireductase invokes the dyshomeostasis of iron (III)/(II) only, while in advanced stages, accumulation of iron in particular areas of the brain follows.	Iron	128-132	synuclein alpha	Homo sapiens	67-82
30583831-4	2019	Juvenile hemochromatosis (JH) is related to hemojuvelin mutation, which is a regulatory peptide of the hepcidin protein, which regulates iron absorption.	Iron	137-141	hemojuvelin BMP co-receptor	Homo sapiens	44-55
30583831-4	2019	Juvenile hemochromatosis (JH) is related to hemojuvelin mutation, which is a regulatory peptide of the hepcidin protein, which regulates iron absorption.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	103-111
32318880-5	2020	Perhaps in the early diseased state, overexpression or mutation of alpha-synuclein/ferrireductase invokes the dyshomeostasis of iron (III)/(II) only, while in advanced stages, accumulation of iron in particular areas of the brain follows.	Iron	192-196	synuclein alpha	Homo sapiens	67-82
30342059-1	2019	ZIP8 is a membrane transporter that facilitates the uptake of divalent metals (e.g., Zn, Mn, Fe, Cd) and the mineral selenite in anionic form.	Iron	93-95	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	0-4
32380365-9	2020	When treated with DFO and NAC for iron chelation and antioxidation, the level of HIF-1a and related cytokines could decrease.	Iron	34-38	synuclein alpha	Homo sapiens	26-29
30583467-1	2018	Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions.	Iron	106-110	heme oxygenase 1	Homo sapiens	0-21
30583467-7	2018	The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator.	Iron	23-27	heme oxygenase 1	Homo sapiens	108-112
30583467-7	2018	The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator.	Iron	23-27	heme oxygenase 1	Homo sapiens	171-175
32276637-9	2020	Moreover, we found that GA-induced iron overload was activated by NMDAR-RASD1 signalling via DMT1 action in the brain.	Iron	35-39	ras related dexamethasone induced 1	Rattus norvegicus	72-77
30204470-1	2018	Hepcidin is a key regulator of iron metabolism and plays an important role in many pathologies.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
32273468-5	2020	cDC-derived hepcidin acted on ferroportin-expressing phagocytes to promote local iron sequestration, which regulated the microbiota and consequently facilitated intestinal repair.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	12-20
30204470-5	2018	Hepcidin plasma concentration was measured by the immunological method in 59 patients with AAV and compared to patients with non-vasculitic etiology of chronic kidney disease, patients on hemodialysis (HD), with systemic lupus erythematodes (SLE) and to healthy controls and blood donors, and was correlated with the parameters of iron metabolism, inflammation, activity of the process and kidney function.	Iron	331-335	hepcidin antimicrobial peptide	Homo sapiens	0-8
30079968-1	2018	Late 3d transition metal disulfides (MS2 , M=Fe, Co, Ni, Cu, Zn) can crystallize in an interesting cubic-pyrite structure, in which all the metal cations are in a low-spin electronic configuration with progressive increase of the eg electrons for M=Fe-Zn.	Iron	45-47	MS2	Homo sapiens	37-40
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	140-144	hemojuvelin BMP co-receptor	Homo sapiens	18-22
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	24-28
28793787-7	2018	Constitutive NRF2 activation and subsequent deregulation of iron metabolism have been implicated in cancer development: NRF2-mediated upregulation of the iron storage protein ferritin or heme oxygenase 1 can lead to enhanced proliferation and therapy resistance.	Iron	60-64	heme oxygenase 1	Homo sapiens	187-203
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	140-144	transferrin receptor 2	Homo sapiens	33-37
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	77-85
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	hemojuvelin BMP co-receptor	Homo sapiens	18-22
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	24-28
30514787-0	2018	The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.	Iron	42-46	glutaredoxin 3	Homo sapiens	27-31
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	transferrin receptor 2	Homo sapiens	33-37
30514787-1	2018	The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus Cryptococcus neoformans In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in C. neoformans Monothiol glutaredoxins are important regulators of iron homeostasis because of their conserved roles in [2Fe-2S] cluster sensing and trafficking.	Iron	19-23	glutaredoxin 3	Homo sapiens	220-224
30514787-1	2018	The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus Cryptococcus neoformans In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in C. neoformans Monothiol glutaredoxins are important regulators of iron homeostasis because of their conserved roles in [2Fe-2S] cluster sensing and trafficking.	Iron	47-51	glutaredoxin 3	Homo sapiens	220-224
30514787-1	2018	The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus Cryptococcus neoformans In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in C. neoformans Monothiol glutaredoxins are important regulators of iron homeostasis because of their conserved roles in [2Fe-2S] cluster sensing and trafficking.	Iron	47-51	glutaredoxin 3	Homo sapiens	220-224
30514787-1	2018	The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus Cryptococcus neoformans In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in C. neoformans Monothiol glutaredoxins are important regulators of iron homeostasis because of their conserved roles in [2Fe-2S] cluster sensing and trafficking.	Iron	47-51	glutaredoxin 3	Homo sapiens	220-224
30514787-2	2018	We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm.	Iron	81-85	glutaredoxin 3	Homo sapiens	24-28
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	77-85
30514787-2	2018	We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm.	Iron	81-85	corepressor interacting with RBPJ, CIR1	Homo sapiens	53-57
30514787-2	2018	We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm.	Iron	81-85	glutaredoxin 3	Homo sapiens	171-175
30514787-2	2018	We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm.	Iron	81-85	corepressor interacting with RBPJ, CIR1	Homo sapiens	182-186
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	hemojuvelin BMP co-receptor	Homo sapiens	18-22
30514787-2	2018	We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm.	Iron	81-85	glutaredoxin 3	Homo sapiens	171-175
30514787-2	2018	We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm.	Iron	209-213	glutaredoxin 3	Homo sapiens	24-28
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	24-28
30514787-2	2018	We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm.	Iron	209-213	corepressor interacting with RBPJ, CIR1	Homo sapiens	53-57
30514787-3	2018	We also found that a grx4 mutant lacking the GRX domain displayed iron-related phenotypes similar to those of a cir1Delta mutant, including poor growth upon iron deprivation.	Iron	66-70	glutaredoxin 3	Homo sapiens	21-25
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	transferrin receptor 2	Homo sapiens	33-37
30514787-3	2018	We also found that a grx4 mutant lacking the GRX domain displayed iron-related phenotypes similar to those of a cir1Delta mutant, including poor growth upon iron deprivation.	Iron	157-161	glutaredoxin 3	Homo sapiens	21-25
30514787-4	2018	Importantly, the grx4 mutant was avirulent in mice, a phenotype consistent with observed defects in the key virulence determinants, capsule and melanin, and poor growth at 37 C. A comparative transcriptome analysis of the grx4 mutant and the WT strain under low-iron and iron-replete conditions confirmed a central role for Grx4 in iron homeostasis.	Iron	262-266	glutaredoxin 3	Homo sapiens	17-21
32258529-5	2020	Mutations in HFE, HFE2, HAMP and TFR2 lead to inadequate or severely reduced hepcidin synthesis that, in turn, induces increased intestinal iron absorption and macrophage iron release leading to tissue iron overload.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	77-85
30514787-4	2018	Importantly, the grx4 mutant was avirulent in mice, a phenotype consistent with observed defects in the key virulence determinants, capsule and melanin, and poor growth at 37 C. A comparative transcriptome analysis of the grx4 mutant and the WT strain under low-iron and iron-replete conditions confirmed a central role for Grx4 in iron homeostasis.	Iron	271-275	glutaredoxin 3	Homo sapiens	17-21
30514787-4	2018	Importantly, the grx4 mutant was avirulent in mice, a phenotype consistent with observed defects in the key virulence determinants, capsule and melanin, and poor growth at 37 C. A comparative transcriptome analysis of the grx4 mutant and the WT strain under low-iron and iron-replete conditions confirmed a central role for Grx4 in iron homeostasis.	Iron	271-275	glutaredoxin 3	Homo sapiens	17-21
32258529-6	2020	The severity of hepcidin down-regulation defines the severity of iron overload and clinical complications.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	16-24
30514787-5	2018	Dysregulation of iron-related metabolism was consistent with grx4 mutant phenotypes related to oxidative stress, mitochondrial function, and DNA repair.	Iron	17-21	glutaredoxin 3	Homo sapiens	61-65
30514787-6	2018	Overall, the phenotypes of the grx4 mutant lacking the GRX domain and the transcriptome sequencing (RNA-Seq) analysis of the mutant support the hypothesis that Grx4 functions as an iron sensor, in part through an interaction with Cir1, to extensively regulate iron homeostasis.IMPORTANCE Fungal pathogens cause life-threatening diseases in humans, particularly in immunocompromised people, and there is a tremendous need for a greater understanding of pathogenesis to support new therapies.	Iron	181-185	glutaredoxin 3	Homo sapiens	160-164
30514787-6	2018	Overall, the phenotypes of the grx4 mutant lacking the GRX domain and the transcriptome sequencing (RNA-Seq) analysis of the mutant support the hypothesis that Grx4 functions as an iron sensor, in part through an interaction with Cir1, to extensively regulate iron homeostasis.IMPORTANCE Fungal pathogens cause life-threatening diseases in humans, particularly in immunocompromised people, and there is a tremendous need for a greater understanding of pathogenesis to support new therapies.	Iron	181-185	corepressor interacting with RBPJ, CIR1	Homo sapiens	230-234
30514787-6	2018	Overall, the phenotypes of the grx4 mutant lacking the GRX domain and the transcriptome sequencing (RNA-Seq) analysis of the mutant support the hypothesis that Grx4 functions as an iron sensor, in part through an interaction with Cir1, to extensively regulate iron homeostasis.IMPORTANCE Fungal pathogens cause life-threatening diseases in humans, particularly in immunocompromised people, and there is a tremendous need for a greater understanding of pathogenesis to support new therapies.	Iron	260-264	glutaredoxin 3	Homo sapiens	160-164
30514787-6	2018	Overall, the phenotypes of the grx4 mutant lacking the GRX domain and the transcriptome sequencing (RNA-Seq) analysis of the mutant support the hypothesis that Grx4 functions as an iron sensor, in part through an interaction with Cir1, to extensively regulate iron homeostasis.IMPORTANCE Fungal pathogens cause life-threatening diseases in humans, particularly in immunocompromised people, and there is a tremendous need for a greater understanding of pathogenesis to support new therapies.	Iron	260-264	corepressor interacting with RBPJ, CIR1	Homo sapiens	230-234
30514787-9	2018	Specifically, we characterized a monothiol glutaredoxin protein, Grx4, that functions as a sensor of iron availability and interacts with regulatory factors to control the ability of C. neoformans to cause disease.	Iron	101-105	glutaredoxin 3	Homo sapiens	65-69
32258529-8	2020	Ferroportin disease is due to loss-of-function mutation of SLC40A1 that impairs the iron export efficiency of ferroportin, causes iron retention in reticuloendothelial cell and hyperferritinemia with normal transferrin saturation.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	59-66
32258529-8	2020	Ferroportin disease is due to loss-of-function mutation of SLC40A1 that impairs the iron export efficiency of ferroportin, causes iron retention in reticuloendothelial cell and hyperferritinemia with normal transferrin saturation.	Iron	130-134	solute carrier family 40 member 1	Homo sapiens	59-66
32048444-0	2020	A hepcidin-based approach for iron therapy in hemodialysis patients: A pilot study.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	2-10
30251657-7	2018	NMR data demonstrate that the recombinant domains of THB2 and THB4 coordinate the ferrous heme iron with the proximal histidine and a lysine from the distal helix.	Iron	95-99	uncharacterized protein	Chlamydomonas reinhardtii	53-57
30251657-7	2018	NMR data demonstrate that the recombinant domains of THB2 and THB4 coordinate the ferrous heme iron with the proximal histidine and a lysine from the distal helix.	Iron	95-99	uncharacterized protein	Chlamydomonas reinhardtii	62-66
32048444-1	2020	INTRODUCTION: Hepcidin is a key factor that regulates iron homeostasis.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	14-22
32048444-2	2020	In hemodialysis patients (HD), a high hepcidin level may decrease intestinal iron absorption and reduce the efficacy of Oral iron vs Intravenous iron therapy.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	38-46
29993346-9	2018	CONCLUSION: These results suggest that the elevation of expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia may be associated with iron loading and oxidative stress.	Iron	162-166	ferritin mitochondrial	Homo sapiens	77-81
32048444-2	2020	In hemodialysis patients (HD), a high hepcidin level may decrease intestinal iron absorption and reduce the efficacy of Oral iron vs Intravenous iron therapy.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	38-46
32048444-2	2020	In hemodialysis patients (HD), a high hepcidin level may decrease intestinal iron absorption and reduce the efficacy of Oral iron vs Intravenous iron therapy.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	38-46
32048444-13	2020	DISCUSSION: Oral iron therapy is effective and safe in EPO-free patients with normal hepcidin levels.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	85-93
32048444-14	2020	These findings suggest that serum hepcidin may be a marker for defining iron therapy strategies in HD patients.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	34-42
30145824-2	2018	Bach1 is a mammalian transcription factor that represses Hmox1, which encodes heme oxygenase-1 (HO-1) that can degrade heme into free iron, carbon monoxide, and biliverdin, to play an important role in antioxidant, anti-inflammatory, and antiapoptotic activities.	Iron	134-138	heme oxygenase 1	Homo sapiens	57-62
32048444-15	2020	HD patients treated with rHU-EPO and with normal hepcidin levels could benefit from oral iron treatment.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	49-57
31958657-4	2020	As-fabricated Fe-N/KCC-1-T exhibited excellent catalytic performance for the ammoxidation of aldehydes under mild reaction conditions.	Iron	14-18	solute carrier family 12 member 4	Homo sapiens	19-24
30584405-0	2018	Serum Concentration of Hepcidin as an Indicator of Iron Reserves in Children.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	23-31
30584405-2	2018	The aim of the research was to determine the serum concentration of hepcidin in children aged 6 months to 2 years and adolescents aged 11 to 19 years which suffer from iron deficiency anemia and compare it with the serum concentration of hepcidin in the control groups, as well as to determine its connection with the parameters of the iron metabolism.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	68-76
30584405-8	2018	The positive correlation between serum hepcidin level and iron in the serum, ferritin, the mean corpuscular volume and transferrin saturation was confirmed, but the negative one occurred in serum hepcidin level, transferrin and reticulocytes.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	39-47
31927402-0	2020	Exploring the interactions of iron and zinc with the microtubule binding repeats R1 and R4.	Iron	30-34	CD1b molecule	Homo sapiens	81-90
30218980-4	2018	Systemic iron administration up-regulated circulating MPO and neutrophil elastase and elevated systemic inflammatory and organ damage markers in WT mice.	Iron	9-13	elastase, neutrophil expressed	Mus musculus	62-81
29548703-3	2018	Hepcidin is an important regulator in iron homeostasis and could be induced by chronic inflammation.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	0-8
29548703-11	2018	Median levels of serum iron, ferritin, and iron saturation were significantly lower in seropositive children with low hepcidin than in those with high hepcidin (P = 0.0123, P = 0.0001, and P = 0.0004, respectively).	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	118-126
31927402-4	2020	And while the Electrospray ionization-mass spectrometry (ESI-MS) confirmed the complexation of Zn2+ and Fe2+ with both R1 and R4, there is no evidence for metalation of R1 or R4 with Fe3+.	Iron	104-108	CD1b molecule	Homo sapiens	119-128
30466598-2	2018	SLs are synthesized via a strict stereo-specific core pathway that leads to the intermediate carlactone, requiring the iron-containing polypeptide DWARF27 (D27) and the carotenoid cleavage dioxygenases 7 (CCD7) and 8 (CCD8).	Iron	119-123	beta-carotene isomerase D27-like protein	Arabidopsis thaliana	147-154
30466598-2	2018	SLs are synthesized via a strict stereo-specific core pathway that leads to the intermediate carlactone, requiring the iron-containing polypeptide DWARF27 (D27) and the carotenoid cleavage dioxygenases 7 (CCD7) and 8 (CCD8).	Iron	119-123	beta-carotene isomerase D27-like protein	Arabidopsis thaliana	156-159
32122995-5	2020	Although modulating cellular iron levels increased IL-2 production by activated T lymphocytes, CD25 expression and pSTAT5 levels were decreased, indicating that iron is necessary for IL-2R-mediated signaling.	Iron	29-33	interleukin 2	Mus musculus	51-55
30809369-10	2019	These results indicate that the impairment of the DMT1 traffic machinery affects subcellular iron homeostasis, promoting Fe(ii) leakage at the Golgi and lysosomal accumulation of Fe(ii) through missorting of DMT1.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	50-54
31671212-1	2020	RATIONALE: Hepcidin is a peptide hormone that plays a central role in regulating iron metabolism.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	11-19
30809369-10	2019	These results indicate that the impairment of the DMT1 traffic machinery affects subcellular iron homeostasis, promoting Fe(ii) leakage at the Golgi and lysosomal accumulation of Fe(ii) through missorting of DMT1.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	208-212
32197673-4	2020	Here we investigated how two Fenton-like systems, Cu/H2O2 and Fe/H2O2/light, affect the infectivity and structural integrity of MS2 coliphage, a frequently used surrogate for human enteric viruses.	Iron	29-31	MS2	Homo sapiens	128-131
30243884-2	2018	We have previously demonstrated that reduced serum ceruloplasmin level exacerbates nigral iron deposition in Parkinson"s disease, although the underlying cause of the low serum ceruloplasmin level in Parkinson"s disease remains unknown.	Iron	90-94	ceruloplasmin	Homo sapiens	51-64
32210768-0	2020	Hepcidin-to-Ferritin Ratio Is Decreased in Astrocytes With Extracellular Alpha-Synuclein and Iron Exposure.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	0-8
30230671-4	2018	WoPPER analysis with time-course validation (RT-qPCR) revealed that HP-14 induces rapid iron starvation in MRSA biofilms, as evident by the activation of iron-acquisition gene clusters in 1 hour.	Iron	88-92	solute carrier family 9 member A6	Homo sapiens	107-111
31320750-0	2020	Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism.	Iron	71-75	ATM serine/threonine kinase	Homo sapiens	53-56
30230671-4	2018	WoPPER analysis with time-course validation (RT-qPCR) revealed that HP-14 induces rapid iron starvation in MRSA biofilms, as evident by the activation of iron-acquisition gene clusters in 1 hour.	Iron	154-158	solute carrier family 9 member A6	Homo sapiens	107-111
30230671-7	2018	These findings suggest that MRSA biofilm viability relies on iron homeostasis.	Iron	61-65	solute carrier family 9 member A6	Homo sapiens	28-32
30340826-0	2018	Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/beta-catenin pathway in colon cancer cells.	Iron	0-4	IL2 inducible T cell kinase	Homo sapiens	72-75
32092301-9	2020	Treatment of starved CRC cells with hepcidin, the major regulator of iron metabolism, induced a significant stimulation of HT-29 cell growth but did not affect the growth of the other cell types.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	36-44
30340826-0	2018	Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/beta-catenin pathway in colon cancer cells.	Iron	0-4	catenin beta 1	Homo sapiens	101-113
30383537-0	2018	Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1alpha/beta and Presenilin 1 expression via PGE2 and PGD2 at the early stage of Alzheimer"s Disease.	Iron	56-60	presenilin 1	Mus musculus	130-142
30383537-3	2018	Using mouse-derived neurons and APP/PS1 transgenic (Tg) mice as model systems, we firstly revealed the mechanisms of APH-1alpha/1beta and presenilin 1 (PS1) upregulation by Fe in prostaglandin (PG) E2- and PGD2-dependent mechanisms.	Iron	173-175	presenilin 1	Mus musculus	138-150
30383537-3	2018	Using mouse-derived neurons and APP/PS1 transgenic (Tg) mice as model systems, we firstly revealed the mechanisms of APH-1alpha/1beta and presenilin 1 (PS1) upregulation by Fe in prostaglandin (PG) E2- and PGD2-dependent mechanisms.	Iron	173-175	presenilin 1	Mus musculus	152-155
31835128-0	2020	Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	47-55
30255609-12	2018	There were weak correlations between the iron turnover and 2D STE parameters.	Iron	41-45	sulfotransferase family 1E member 1	Homo sapiens	62-65
31835128-15	2020	The hepcidin response to higher body iron levels and/or inflammation appeared to be functional in these patients, despite the presence of liver disease.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	4-12
31471929-4	2020	Hepcidin is a crucial regulator of iron homeostasis in the brain.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
31471929-5	2020	Recent studies have suggested that upregulating brain hepcidin levels can significantly reduce brain iron content through the regulation of iron transport protein expression in the blood-brain barrier and in neurons and astrocytes.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	54-62
29148316-1	2018	Human Ceruloplasmin belongs to the family of multi-copper oxidases and it is involved in different physiological processes, copper ion transport, iron metabolism, iron homeostasis, and biogenic amine metabolism.	Iron	146-150	ceruloplasmin	Homo sapiens	6-19
29148316-1	2018	Human Ceruloplasmin belongs to the family of multi-copper oxidases and it is involved in different physiological processes, copper ion transport, iron metabolism, iron homeostasis, and biogenic amine metabolism.	Iron	163-167	ceruloplasmin	Homo sapiens	6-19
31471929-5	2020	Recent studies have suggested that upregulating brain hepcidin levels can significantly reduce brain iron content through the regulation of iron transport protein expression in the blood-brain barrier and in neurons and astrocytes.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	54-62
31471929-6	2020	In this review, we focus on the discussion of the therapeutic potential of hepcidin in iron-associated neurodegenerative diseases and also provide a systematic overview of recent research progress on how misregulated brain iron metabolism is involved in the development of multiple neurodegenerative disorders.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	75-83
32121273-2	2020	The hallmark of this regulated cell death is the presence of iron-driven lipid peroxidation; the activation of key genes related to this process such as glutathione peroxidase-4 (gpx4), acyl-CoA synthetase long-chain family member-4 (acsl4), carbonyl reductase [NADPH] 3 (cbr3), and prostaglandin peroxidase synthase-2 (ptgs2); and morphological changes including shrunken and electron-dense mitochondria.	Iron	61-65	glutathione peroxidase 4	Homo sapiens	153-177
30247706-0	2018	Umbilical Cord Hepcidin Concentrations Are Positively Associated with the Variance in Iron Status among Multiple Birth Neonates.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	15-23
30247706-1	2018	Background: Hepcidin is a systemic regulator of iron homeostasis.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	12-20
32121273-2	2020	The hallmark of this regulated cell death is the presence of iron-driven lipid peroxidation; the activation of key genes related to this process such as glutathione peroxidase-4 (gpx4), acyl-CoA synthetase long-chain family member-4 (acsl4), carbonyl reductase [NADPH] 3 (cbr3), and prostaglandin peroxidase synthase-2 (ptgs2); and morphological changes including shrunken and electron-dense mitochondria.	Iron	61-65	glutathione peroxidase 4	Homo sapiens	179-183
30348300-2	2018	analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene.	Iron	78-82	erythropoietin	Mus musculus	26-40
30348300-2	2018	analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene.	Iron	78-82	erythropoietin	Mus musculus	197-211
32106271-1	2020	BACKGROUND: Hepcidin is an iron regulating hormone, and exercise-induced hepcidin elevation is suggested to increase the risk of iron deficiency among athletes.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	12-20
30348300-2	2018	analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene.	Iron	134-138	erythropoietin	Mus musculus	26-40
30348300-2	2018	analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene.	Iron	134-138	erythropoietin	Mus musculus	197-211
30348300-3	2018	The authors show that excess iron decreases levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the main driver of erythropoietin production in hypoxia and anemia.	Iron	29-33	endothelial PAS domain protein 1	Mus musculus	54-99
30348300-3	2018	The authors show that excess iron decreases levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the main driver of erythropoietin production in hypoxia and anemia.	Iron	29-33	endothelial PAS domain protein 1	Mus musculus	101-110
30348300-3	2018	The authors show that excess iron decreases levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the main driver of erythropoietin production in hypoxia and anemia.	Iron	29-33	erythropoietin	Mus musculus	132-146
31986002-2	2020	Particularly, the M2(dobdc) (dobdc4- = 2,5-dioxidobenzenedicarboxylate, M2+ = Co2+, Mn2+, Fe2+...) framework has been the drosophila of this research field and delivered groundbreaking results in terms of sorption selectivity.	Iron	90-93	Enhancer of split m2, Bearded family member	Drosophila melanogaster	18-27
30420953-1	2018	Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-derived peptide hormone.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	76-84
30420953-2	2018	Hepcidin inhibits iron entry into plasma by binding to and inactivating the iron exporter ferroportin in target cells, such as duodenal enterocytes and tissue macrophages.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
30420953-2	2018	Hepcidin inhibits iron entry into plasma by binding to and inactivating the iron exporter ferroportin in target cells, such as duodenal enterocytes and tissue macrophages.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
31995045-1	2020	Assembly of a novel ethylenedithio-tetrathiafulvalene (EDT-TTF) derivative bearing two adjacent 4-thiopyridyl groups with M(NCS)2 nodes (M = Fe, Co) leads to two isostructural 1D coordination polymers showing an enhancement of their electronic conductivity by six orders of magnitude (10-6 vs. 10-12 S cm-1), upon surface oxidation by iodine and subsequent generation of EDT-TTF-based radicals.	Iron	141-143	ras homolog family member H	Homo sapiens	59-62
30420953-3	2018	Hepcidin is induced in response to increased body iron stores to inhibit further iron absorption and prevent iron overload.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
30420953-3	2018	Hepcidin is induced in response to increased body iron stores to inhibit further iron absorption and prevent iron overload.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
30420953-3	2018	Hepcidin is induced in response to increased body iron stores to inhibit further iron absorption and prevent iron overload.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
32079434-0	2022	Increased hepcidin levels in preeclampsia: a protective mechanism against iron overload mediated oxidative stress?	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	10-18
32079434-4	2022	Hepcidin a regulator of iron metabolism protects the cells from iron mediated cytotoxicity.Objective: To find out whether hepcidin gets induced as a protective mechanism in preeclampsia patients in order to combat the environment of iron overload, oxidative stress, and endothelial dysfunction.Methods: A cross-sectional study with follow up was carried out in a South Indian Tamil population.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	0-8
32079434-4	2022	Hepcidin a regulator of iron metabolism protects the cells from iron mediated cytotoxicity.Objective: To find out whether hepcidin gets induced as a protective mechanism in preeclampsia patients in order to combat the environment of iron overload, oxidative stress, and endothelial dysfunction.Methods: A cross-sectional study with follow up was carried out in a South Indian Tamil population.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	122-130
30360575-2	2018	In mammals, there is a complex pathway devoted to iron regulation, whose key protein is hepcidin (Hepc), which is a powerful iron absorption inhibitor mainly produced by the liver.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	88-96
32079434-4	2022	Hepcidin a regulator of iron metabolism protects the cells from iron mediated cytotoxicity.Objective: To find out whether hepcidin gets induced as a protective mechanism in preeclampsia patients in order to combat the environment of iron overload, oxidative stress, and endothelial dysfunction.Methods: A cross-sectional study with follow up was carried out in a South Indian Tamil population.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
30360575-2	2018	In mammals, there is a complex pathway devoted to iron regulation, whose key protein is hepcidin (Hepc), which is a powerful iron absorption inhibitor mainly produced by the liver.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	98-102
30360575-2	2018	In mammals, there is a complex pathway devoted to iron regulation, whose key protein is hepcidin (Hepc), which is a powerful iron absorption inhibitor mainly produced by the liver.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	88-96
32079434-4	2022	Hepcidin a regulator of iron metabolism protects the cells from iron mediated cytotoxicity.Objective: To find out whether hepcidin gets induced as a protective mechanism in preeclampsia patients in order to combat the environment of iron overload, oxidative stress, and endothelial dysfunction.Methods: A cross-sectional study with follow up was carried out in a South Indian Tamil population.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	122-130
30360575-2	2018	In mammals, there is a complex pathway devoted to iron regulation, whose key protein is hepcidin (Hepc), which is a powerful iron absorption inhibitor mainly produced by the liver.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	98-102
30360575-3	2018	Transferrin receptor 2 (Tfr2) is one of the hepcidin regulators, and mutations in TFR2 gene are responsible for type 3 hereditary hemochromatosis (HFE3), a genetically heterogeneous disease characterized by systemic iron overload.	Iron	216-220	transferrin receptor 2	Homo sapiens	0-22
30360575-3	2018	Transferrin receptor 2 (Tfr2) is one of the hepcidin regulators, and mutations in TFR2 gene are responsible for type 3 hereditary hemochromatosis (HFE3), a genetically heterogeneous disease characterized by systemic iron overload.	Iron	216-220	transferrin receptor 2	Homo sapiens	24-28
30360575-3	2018	Transferrin receptor 2 (Tfr2) is one of the hepcidin regulators, and mutations in TFR2 gene are responsible for type 3 hereditary hemochromatosis (HFE3), a genetically heterogeneous disease characterized by systemic iron overload.	Iron	216-220	transferrin receptor 2	Homo sapiens	82-86
30360575-3	2018	Transferrin receptor 2 (Tfr2) is one of the hepcidin regulators, and mutations in TFR2 gene are responsible for type 3 hereditary hemochromatosis (HFE3), a genetically heterogeneous disease characterized by systemic iron overload.	Iron	216-220	transferrin receptor 2	Homo sapiens	147-151
32079434-4	2022	Hepcidin a regulator of iron metabolism protects the cells from iron mediated cytotoxicity.Objective: To find out whether hepcidin gets induced as a protective mechanism in preeclampsia patients in order to combat the environment of iron overload, oxidative stress, and endothelial dysfunction.Methods: A cross-sectional study with follow up was carried out in a South Indian Tamil population.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
30360575-4	2018	It has been recently pointed out that Hepc production and iron regulation could be exerted also in tissues other than liver, and that Tfr2 has an extrahepatic role in iron metabolism as well.	Iron	167-171	transferrin receptor 2	Homo sapiens	134-138
32079434-4	2022	Hepcidin a regulator of iron metabolism protects the cells from iron mediated cytotoxicity.Objective: To find out whether hepcidin gets induced as a protective mechanism in preeclampsia patients in order to combat the environment of iron overload, oxidative stress, and endothelial dysfunction.Methods: A cross-sectional study with follow up was carried out in a South Indian Tamil population.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	122-130
32079304-6	2020	At molecular level, cells cultured in iron-enriched conditions show increased ARG1 and PU.1, and decreased IRF8 expression.	Iron	38-42	Spi-1 proto-oncogene	Homo sapiens	87-91
30349956-5	2018	From the principal corresponding analysis (PCA) results retrieved from PC3 suggest that Fe, Mn, Cr, Cu, Pb, and Ni have common origin and are mainly due to anthropogenic input, inorganic fertilizers in agriculture, human activities, sewage effluents, traffic, and boat activities.	Iron	88-90	chromobox 8	Homo sapiens	71-74
32079304-6	2020	At molecular level, cells cultured in iron-enriched conditions show increased ARG1 and PU.1, and decreased IRF8 expression.	Iron	38-42	interferon regulatory factor 8	Homo sapiens	107-111
32074970-0	2020	Nano-Sized Fe(III) Oxide Particles Starting from an Innovative and Eco-Friendly Synthesis Method.	Iron	11-24	ciliogenesis associated kinase 1	Homo sapiens	67-70
30301129-8	2018	Hepcidin controls dietary iron absorption and distribution in metabolic tissues, but it is unknown whether genetic variation influencing hepcidin expression modifies susceptibility to dietary iron-induced insulin resistance.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	0-8
32059452-1	2020	Heme oxygenase-1 (HO-1), an intracellular enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide, exerts anti-inflammatory and cytoprotective effects against endothelial cell injury.	Iron	110-114	heme oxygenase 1	Homo sapiens	0-16
30097509-10	2018	ERFE can act as a natural ligand trap generated by stimulated erythropoiesis to regulate the availability of iron.	Iron	109-113	erythroferrone	Homo sapiens	0-4
29859760-3	2018	Using a combination of human, bovine, and mouse eyes as models, we report the expression of iron export proteins ferroportin and ceruloplasmin, and major iron uptake and storage proteins transferrin, transferrin receptor, and ferritin in the ciliary epithelium, indicating active exchange of iron at this site.	Iron	92-96	ceruloplasmin	Mus musculus	129-142
32059452-1	2020	Heme oxygenase-1 (HO-1), an intracellular enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide, exerts anti-inflammatory and cytoprotective effects against endothelial cell injury.	Iron	110-114	heme oxygenase 1	Homo sapiens	18-22
32117974-6	2020	This study aims to investigate the effect of decreased alpha-taxilin levels in HCV-replicating cells on recycling of TfR, its amount on the cell surface, on iron uptake, and the impact of a disturbed TfR recycling on HCV superinfection exclusion.	Iron	157-161	taxilin alpha	Homo sapiens	55-68
30275363-0	2018	Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	12-20
30275363-6	2018	In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024).	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	31-39
30275363-9	2018	The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	105-113
32117974-16	2020	Taken together, the diminished level of alpha-taxilin in HCV-replicating cells prevents recycling of TfR leading to decreased transferrin binding and iron uptake.	Iron	150-154	taxilin alpha	Homo sapiens	40-53
31721611-0	2020	Increased divalent metal ion transporter-1 (DMT1) and ferroportin-1 (FPN1) expression with enhanced iron absorption in ulcerative colitis human colon.	Iron	100-104	solute carrier family 11 member 2	Homo sapiens	44-48
30145632-2	2018	Emerging evidence suggested that iron accumulation and lipid peroxidation can be discovered in various neurological diseases, accompanied with reduction of glutathione (GSH) and glutathione peroxidase 4 (GPX4).	Iron	33-37	glutathione peroxidase 4	Homo sapiens	178-202
30145632-2	2018	Emerging evidence suggested that iron accumulation and lipid peroxidation can be discovered in various neurological diseases, accompanied with reduction of glutathione (GSH) and glutathione peroxidase 4 (GPX4).	Iron	33-37	glutathione peroxidase 4	Homo sapiens	204-208
31721611-0	2020	Increased divalent metal ion transporter-1 (DMT1) and ferroportin-1 (FPN1) expression with enhanced iron absorption in ulcerative colitis human colon.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	54-67
30171894-0	2018	Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD.	Iron	92-96	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	12-18
30171894-7	2018	To gain some understanding on the molecular basis of this effect, we focused on the regulation of Kir6.2 deletion on iron metabolism which is tightly associated with DA neuron damage.	Iron	117-121	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	98-104
30171894-8	2018	We found that Kir6.2 knockout suppressed the excessive iron accumulation in MPTP-treated mouse midbrain and inhibited the upregulation of ferritin light chain (FTL), which is a main intracellular iron storage protein.	Iron	55-59	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	14-20
30171894-8	2018	We found that Kir6.2 knockout suppressed the excessive iron accumulation in MPTP-treated mouse midbrain and inhibited the upregulation of ferritin light chain (FTL), which is a main intracellular iron storage protein.	Iron	196-200	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	14-20
31721611-0	2020	Increased divalent metal ion transporter-1 (DMT1) and ferroportin-1 (FPN1) expression with enhanced iron absorption in ulcerative colitis human colon.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	69-73
31721611-2	2020	Most iron absorption occurs in the duodenum via divalent metal transporter 1 (DMT1)-mediated uptake and ferroportin 1 (FPN1)-mediated export across the apical and basolateral membranes, respectively.	Iron	5-9	solute carrier family 11 member 2	Homo sapiens	48-76
30066882-2	2018	However, emerging evidence indicates that p53 is also involved in inducing ferroptosis, which is a unique iron-dependent form of non-apoptotic cell death triggered by the RAS-selective lethal small molecule erastin.	Iron	106-110	transformation related protein 53, pseudogene	Mus musculus	42-45
31721611-2	2020	Most iron absorption occurs in the duodenum via divalent metal transporter 1 (DMT1)-mediated uptake and ferroportin 1 (FPN1)-mediated export across the apical and basolateral membranes, respectively.	Iron	5-9	solute carrier family 11 member 2	Homo sapiens	78-82
31721611-2	2020	Most iron absorption occurs in the duodenum via divalent metal transporter 1 (DMT1)-mediated uptake and ferroportin 1 (FPN1)-mediated export across the apical and basolateral membranes, respectively.	Iron	5-9	solute carrier family 40 member 1	Homo sapiens	104-117
31721611-2	2020	Most iron absorption occurs in the duodenum via divalent metal transporter 1 (DMT1)-mediated uptake and ferroportin 1 (FPN1)-mediated export across the apical and basolateral membranes, respectively.	Iron	5-9	solute carrier family 40 member 1	Homo sapiens	119-123
31721611-10	2020	Increased DMT1 expression was associated with enhanced 2-(3-carbamimidoylsulfanylmethyl-benzyl)-isothiourea (CISMBI, DMT1 specific inhibitor)-sensitive 59Fe uptake in UC human colon.	Iron	152-156	solute carrier family 11 member 2	Homo sapiens	10-14
29959986-6	2018	Long-term iron exposure resulted in iron accumulation, cytosolic ROS formation and increased heme oxygenase 1 (HMOX-1) mRNA expression (all p &lt; 0.001).	Iron	10-14	heme oxygenase 1	Homo sapiens	93-109
29959986-6	2018	Long-term iron exposure resulted in iron accumulation, cytosolic ROS formation and increased heme oxygenase 1 (HMOX-1) mRNA expression (all p &lt; 0.001).	Iron	10-14	heme oxygenase 1	Homo sapiens	111-117
31721611-10	2020	Increased DMT1 expression was associated with enhanced 2-(3-carbamimidoylsulfanylmethyl-benzyl)-isothiourea (CISMBI, DMT1 specific inhibitor)-sensitive 59Fe uptake in UC human colon.	Iron	152-156	solute carrier family 11 member 2	Homo sapiens	117-121
32025811-4	2020	Here, we describe existing findings regarding the interaction of iron with neuromelanin and alpha synuclein, the iron deposition in experimental animal model of PD and sporadic and familial PD patients, and the treatment option involving the use of iron chelators for targeting the aberration of iron level in brain.	Iron	65-69	synuclein alpha	Homo sapiens	75-107
30040983-1	2018	Heme Oxygenase-1 (HO-1), a stress- responsive enzyme which catalyzes heme degradation into iron, carbon monoxide, and biliverdin, exerts a neuroprotective role involving many different signaling pathways.	Iron	91-95	heme oxygenase 1	Homo sapiens	0-16
30040983-1	2018	Heme Oxygenase-1 (HO-1), a stress- responsive enzyme which catalyzes heme degradation into iron, carbon monoxide, and biliverdin, exerts a neuroprotective role involving many different signaling pathways.	Iron	91-95	heme oxygenase 1	Homo sapiens	18-22
31411363-1	2020	AIM: The aim of this study was to compare changes in serum hepcidin levels in paediatric patients with inflammatory bowel disease during therapy and correlate them with markers of iron metabolism, inflammation and type of treatment.	Iron	180-184	hepcidin antimicrobial peptide	Homo sapiens	59-67
30201724-5	2018	Here, we investigated the potential scaffold function of human CFD1 (NUBP2) in CFD1-depleted HeLa cells by measuring Fe-S enzyme activities or 55Fe incorporation into Fe-S target proteins.	Iron	117-121	NUBP iron-sulfur cluster assembly factor 2, cytosolic	Homo sapiens	69-74
30201724-5	2018	Here, we investigated the potential scaffold function of human CFD1 (NUBP2) in CFD1-depleted HeLa cells by measuring Fe-S enzyme activities or 55Fe incorporation into Fe-S target proteins.	Iron	167-171	NUBP iron-sulfur cluster assembly factor 2, cytosolic	Homo sapiens	69-74
30201724-6	2018	We show that CFD1, in complex with NBP35 (NUBP1), performs a crucial role in the maturation of all tested cytosolic and nuclear Fe-S proteins, including essential ones involved in protein translation and DNA maintenance.	Iron	128-132	NUBP iron-sulfur cluster assembly factor 2, cytosolic	Homo sapiens	13-17
30201724-6	2018	We show that CFD1, in complex with NBP35 (NUBP1), performs a crucial role in the maturation of all tested cytosolic and nuclear Fe-S proteins, including essential ones involved in protein translation and DNA maintenance.	Iron	128-132	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	35-40
31411363-8	2020	While hepcidin level changes correlated with disease activity and inflammatory parameters (erythrocyte sedimentation rate, C-reactive protein), in CD patients, they correlated only with serum iron levels in patients with UC.	Iron	192-196	hepcidin antimicrobial peptide	Homo sapiens	6-14
30201724-6	2018	We show that CFD1, in complex with NBP35 (NUBP1), performs a crucial role in the maturation of all tested cytosolic and nuclear Fe-S proteins, including essential ones involved in protein translation and DNA maintenance.	Iron	128-132	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	42-47
30201724-7	2018	CFD1 also matures iron regulatory protein 1 and thus is critical for cellular iron homeostasis.	Iron	18-22	NUBP iron-sulfur cluster assembly factor 2, cytosolic	Homo sapiens	0-4
31665878-2	2020	METHODS: A proposed new mechanism of exercise-induced iron deficiency in athletes involves the iron-regulatory hormone hepcidin, however, there is limited information on this amongst elite athletes.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	119-127
30248094-2	2018	Studies in cultured cells have ascribed a role for HRG1/SLC48A1 in heme-iron transport but the in vivo function of this heme transporter is unclear.	Iron	72-76	solute carrier family 48 member 1b	Danio rerio	51-55
31790793-0	2020	GAPDH, rhbC, and vapA gene expression in Rhodococcus equi cultured under different iron concentrations.	Iron	83-87	virulence-associated 15-17 kDa antigen	Rhodococcus equi	17-21
30248094-3	2018	Here we present genetic evidence in a zebrafish model that Hrg1 is essential for macrophage-mediated heme-iron recycling during erythrophagocytosis in the kidney.	Iron	106-110	solute carrier family 48 member 1b	Danio rerio	59-63
30248094-4	2018	Furthermore, we show that zebrafish Hrg1a and its paralog Hrg1b are functional heme transporters, and genetic ablation of both transporters in double knockout (DKO) animals shows lower iron accumulation concomitant with higher amounts of heme sequestered in kidney macrophages.	Iron	185-189	solute carrier family 48 member 1b	Danio rerio	36-41
30248094-6	2018	Taken together, our results establish the kidney as the major organ for erythrophagocytosis and identify Hrg1 as an important regulator of heme-iron recycling by macrophages in the adult zebrafish.	Iron	144-148	solute carrier family 48 member 1b	Danio rerio	105-109
30298070-2	2018	Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a hormone peptide able to bind to ferroportin, leading to its degradation.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	100-108
31790793-8	2020	Iron restriction proportionally decreased R. equi growth rates, and induced high expression of both GAPDH and vapA.	Iron	0-4	virulence-associated 15-17 kDa antigen	Rhodococcus equi	110-114
31838658-3	2020	We proposed to use it to carry another key protein of iron metabolism, hepcidin that is a small hormone peptide that control systemic iron homeostasis.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	71-79
30136570-4	2018	We find a correlation between the temperature dependencies of the junction resistance and the Fe spin state within the device"s [Fe(H2B(pz)2)2(NH2-phen)] molecular film.	Iron	94-96	H2B clustered histone 21	Homo sapiens	132-135
31838658-3	2020	We proposed to use it to carry another key protein of iron metabolism, hepcidin that is a small hormone peptide that control systemic iron homeostasis.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	71-79
30137089-5	2018	Holo BOLA3-GLRX5 transfers clusters to apo acceptors at rates comparable to other Fe-S cluster trafficking proteins.	Iron	82-86	bolA family member 3	Homo sapiens	5-10
31755170-3	2020	In this study, the localizations of hepcidin, ferroportin, and hephaestin, which are known to be involved in iron efflux, were immunohistochemically examined in autopsied human brains.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	36-44
30137089-5	2018	Holo BOLA3-GLRX5 transfers clusters to apo acceptors at rates comparable to other Fe-S cluster trafficking proteins.	Iron	82-86	glutaredoxin 5	Homo sapiens	11-16
31090188-5	2020	In the multivariate regression model, independent predictors of serum hepcidin levels in ESRD patients before maintenance dialysis were interleukin-6, ferritin, phosphate, iron, and aspartate transaminase.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	70-78
30141807-0	2018	Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.	Iron	0-4	lipin 1	Homo sapiens	80-86
31090188-6	2020	Six months after initiating dialysis, serum hepcidin levels were independently predicted by ferritin, total iron binding capacity (TIBC), and aspartate transaminase in all patients, whereas by ferritin and TIBC in PD patients, and ferritin, TIBC, and 24-h urine volume in HD patients.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	44-52
30141807-4	2018	However, the involvement of lipin1 in the regulation of iron metabolism is unknown.	Iron	56-60	lipin 1	Homo sapiens	28-34
31996186-2	2020	Lactoferrin is an antimicrobial, antioxidant, anti-inflammatory iron-carrying, bifidogenic glycoprotein found in all vertebrates and in mammalian milk, leukocytes and exocrine secretions.	Iron	64-68	lactotransferrin	Bos taurus	0-11
30141807-6	2018	Our results showed that only intracellular iron content was significantly decreased by lipin1 overexpression.	Iron	43-47	lipin 1	Homo sapiens	87-93
30141807-9	2018	Conversely, after lipin1 was down regulated with siRNA, we found that cell proliferation was promoted, accompanied by an increase in iron content, and the downregulation of p53 and p21.	Iron	133-137	lipin 1	Homo sapiens	18-24
30141807-10	2018	Our data indicate that lipin1 overexpression may cause reduction of intracellular iron content, which could activate the p53-p21-p27 signaling pathways, leading to cell cycle arrest at the G0/G1 phase in the hepatic carcinoma cells.	Iron	82-86	lipin 1	Homo sapiens	23-29
31969582-2	2020	Myoglobin from many species is also an important nutritional source of bioavailable iron.	Iron	84-88	myoglobin	Homo sapiens	0-9
30141807-10	2018	Our data indicate that lipin1 overexpression may cause reduction of intracellular iron content, which could activate the p53-p21-p27 signaling pathways, leading to cell cycle arrest at the G0/G1 phase in the hepatic carcinoma cells.	Iron	82-86	H3 histone pseudogene 16	Homo sapiens	125-128
30141807-10	2018	Our data indicate that lipin1 overexpression may cause reduction of intracellular iron content, which could activate the p53-p21-p27 signaling pathways, leading to cell cycle arrest at the G0/G1 phase in the hepatic carcinoma cells.	Iron	82-86	interferon alpha inducible protein 27	Homo sapiens	129-132
30141807-11	2018	Subsequently, we identified the putative cause for the decrease of the intracellular iron content induced by lipin1 overexpression.	Iron	85-89	lipin 1	Homo sapiens	109-115
30141807-12	2018	Our results suggested that the intracellular iron reduction was due to the increase in the expression of ferroportin, an iron export protein in the stable cells overexpressing lipin1.	Iron	45-49	lipin 1	Homo sapiens	176-182
32038278-1	2019	The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1).	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	26-34
30224633-2	2018	In this strategy, a floating electrode (FE)-based carbon nanotube (CNT) field effect transistor (FET) was functionalized with human olfactory receptor 1A2 (hOR1A2)-embedded NDs (hOR1A2NDs).	Iron	40-42	olfactory receptor family 1 subfamily A member 2	Homo sapiens	132-154
30224633-2	2018	In this strategy, a floating electrode (FE)-based carbon nanotube (CNT) field effect transistor (FET) was functionalized with human olfactory receptor 1A2 (hOR1A2)-embedded NDs (hOR1A2NDs).	Iron	40-42	olfactory receptor family 1 subfamily A member 2	Homo sapiens	156-162
32038278-1	2019	The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1).	Iron	55-59	solute carrier family 40 member 1	Homo sapiens	127-140
32038278-1	2019	The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1).	Iron	55-59	solute carrier family 40 member 1	Homo sapiens	142-146
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	138-142
32038278-1	2019	The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1).	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	26-34
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	215-223
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	226-230
32038278-1	2019	The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1).	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	127-140
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	70-74	solute carrier family 11 member 2	Homo sapiens	138-142
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	215-223
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	226-230
32038278-1	2019	The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1).	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	142-146
32038278-2	2019	Circulating levels of hepcidin and the iron storage protein ferritin are elevated during the recovery period after acute endurance exercise, which can be interpreted as an acute phase reaction to intense exercise with far-reaching consequences for iron metabolism and homeostasis.	Iron	248-252	hepcidin antimicrobial peptide	Homo sapiens	22-30
31936571-3	2020	Instead, ferroptotic cells die following iron-dependent lipid peroxidation, a process which is antagonised by glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1).	Iron	41-45	glutathione peroxidase 4	Homo sapiens	110-134
30186425-5	2018	To this end, using the Roche biochemical autoanalyzer, we detected the concentration of iron, soluble transferrin receptor 2 (TFR2), and hepcidin, a key peptide regulating iron homeostasis, in the sera from patients with OP.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	137-145
32990287-2	2020	Hepcidin is a peptide hormone responsible for systemic iron homeostasis and simultaneously the inflammatory response protein, induced in response to interleukin 6 (IL-6).	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
29680060-1	2018	Lactoferrin is an iron-binding cationic glycoprotein (pI = 8.7) beneficial for mammal health, especially udder and milk preservation.	Iron	18-22	lactotransferrin	Bos taurus	0-11
31678680-0	2020	Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis.	Iron	11-15	lactotransferrin	Bos taurus	33-44
29971532-1	2018	PURPOSE: Ferroptosis is a programmed form of iron-dependent cell death caused by lipid hydroperoxide accumulation, which can be prevented by glutathione peroxidase 4 (GPx4) activity.	Iron	45-49	glutathione peroxidase 4	Mus musculus	141-165
29971532-1	2018	PURPOSE: Ferroptosis is a programmed form of iron-dependent cell death caused by lipid hydroperoxide accumulation, which can be prevented by glutathione peroxidase 4 (GPx4) activity.	Iron	45-49	glutathione peroxidase 4	Mus musculus	167-171
31678680-4	2020	Here, we present data on the differential effects of native and iron-saturated bovine lactoferrin (bLf), an iron-chelating glycoprotein of the innate immune response, in inhibiting migration in a human glioblastoma cell line.	Iron	64-68	lactotransferrin	Bos taurus	86-97
29974998-6	2018	Moreover, the expression of HO-1, a functional modulator of Tregs, was decreased in vitiligo Tregs, and the concentrations of HO-1 metabolites, including bilirubin, CoHb and iron, were correspondingly decreased in serum of vitiligo patients.	Iron	174-178	heme oxygenase 1	Homo sapiens	28-32
31678680-4	2020	Here, we present data on the differential effects of native and iron-saturated bovine lactoferrin (bLf), an iron-chelating glycoprotein of the innate immune response, in inhibiting migration in a human glioblastoma cell line.	Iron	108-112	lactotransferrin	Bos taurus	86-97
31830663-5	2020	The discovery of hepcidin and its role in iron homeostasis has revolutionized our understanding of the pathogenesis of iron deficiency and iron overload states.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	17-25
29960117-1	2018	Dietary iron overload in rodents impairs growth and causes cardiac hypertrophy, serum and tissue copper depletion, depression of serum ceruloplasmin (Cp) activity and anemia.	Iron	8-12	ceruloplasmin	Mus musculus	135-148
30651671-15	2018	Results: There was a significant correlation between the values of serum hepcidin and Hb (P &lt; 0.001) before and after oral supplementation of elemental iron.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	73-81
31830663-5	2020	The discovery of hepcidin and its role in iron homeostasis has revolutionized our understanding of the pathogenesis of iron deficiency and iron overload states.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	17-25
30651671-16	2018	After oral supplementation of iron, hematocrit improved in Group I along with reduction in serum hepcidin.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	97-105
30651671-17	2018	Conclusion: It can be concluded that reduction of serum hepcidin is indicative of improvement in iron stores of body.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	56-64
31657968-3	2020	The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis.	Iron	24-28	interleukin 1 alpha	Homo sapiens	226-230
30651671-18	2018	Hence, serum hepcidin can be utilized as a diagnostic marker to assess iron stores in OSMF.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	13-21
30315639-3	2018	EPO also stimulates the production of the hormone erythroferrone (ERFE) which acts to suppress hepcidin production, thus increasing dietary iron absorption and mobilizing stored iron for use in erythropoiesis.	Iron	140-144	erythropoietin	Mus musculus	0-3
30315639-3	2018	EPO also stimulates the production of the hormone erythroferrone (ERFE) which acts to suppress hepcidin production, thus increasing dietary iron absorption and mobilizing stored iron for use in erythropoiesis.	Iron	178-182	erythropoietin	Mus musculus	0-3
31733428-9	2020	However, a variation between tetrameric Hb(III) on one side and Hp1-1:Hb(III), Hp2-2:Hb(III), alpha(III), and beta(III) on the other side for the rate-limiting step (likely referable to the dissociation of heme-coordinated H2O from the heme-Fe(III) atom) suggests a structural change(s) upon dimers to tetramer assembly in Hb(III).	Iron	241-243	chromobox 5	Homo sapiens	64-67
30234111-4	2018	Herein, we describe the first reported role of MyD88 in an interconnection between innate immunity and the iron-sensing pathway (BMP/SMAD4).	Iron	107-111	bone morphogenetic protein 1	Homo sapiens	129-132
30234111-6	2018	The iron regulatory hormone hepcidin is indispensable for the intestinal regulation of iron absorption and iron recycling by macrophages.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
30234111-6	2018	The iron regulatory hormone hepcidin is indispensable for the intestinal regulation of iron absorption and iron recycling by macrophages.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	28-36
30234111-6	2018	The iron regulatory hormone hepcidin is indispensable for the intestinal regulation of iron absorption and iron recycling by macrophages.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	28-36
32950976-2	2020	Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	61-69
30150549-3	2018	Hepcidin binds to ferroportin, thereby inhibiting iron absorption/efflux.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
30150549-4	2018	Inflammation in CKD increases ferritin and hepcidin independent of iron status, which reduce iron availability.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	43-51
30150549-6	2018	Inflammation reduces predictive values of ferritin and hepcidin for iron status and responsiveness to iron therapy.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	55-63
32950976-3	2020	Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin.	Iron	55-59	ret proto-oncogene	Homo sapiens	0-3
32950976-3	2020	Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	94-102
32115450-0	2020	Dose Effect of Bovine Lactoferrin Fortification on Iron Metabolism of Anemic Infants.	Iron	51-55	lactotransferrin	Bos taurus	22-33
29712435-4	2018	HIF stabilization also decreases hepcidin, a hormone of hepatic origin, which regulates iron homeostasis.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	33-41
31822155-7	2020	As reported, the ion content (Na+, K+ and Fe2+), apoplast acidification ability, and salt tolerance were also abnormal in the quadruple mutants and/or the SAUR41 overexpression lines.	Iron	42-46	SAUR-like auxin-responsive protein family	Arabidopsis thaliana	155-161
30158827-4	2018	Snx3 binds to membranes via a phox homolog (PX) domain that binds phosphatidylinositol 3-phosphate (PI3P), and in human cells its cargo proteins are the transferrin and Wnt receptors and the divalent metal ion transporter, whereas in yeast the best characterized cargo is the iron permease Ftr1.	Iron	276-280	sorting nexin 3	Homo sapiens	0-4
32507812-1	2020	Hepcidin is a key molecule that regulates iron metabolism in the body.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
30019062-2	2018	Upon iron removal, apoferritin was shown to allow the encapsulation of an artificial transfer hydrogenase (ATHase) based on the streptavidin-biotin technology.	Iron	5-9	ferritin heavy chain 1	Homo sapiens	19-30
32507812-2	2020	Iron refractory iron deficiency anemia (IRIDA) is a genetic disorder caused by a defect in the TMPRSS6 gene encoding matriptase-2, a transmembrane serine protease that physiologically inhibits hepcidin production.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	193-201
32759562-4	2020	Recently, hepatic hepcidin was found to inhibit iron absorption from the gastrointestinal tract, and hepcidin production is reduced by erythroid factors, such as growth differentiation factor 15 (GDF15) and erythroferrone.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	18-26
30186818-0	2018	Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C. Hepatic iron accumulation is generally increased in the chronic hepatitis C (CHC) liver; however, the precise mechanism of such accumulation remains unclear.	Iron	19-23	solute carrier family 40 member 1	Homo sapiens	59-72
30186818-0	2018	Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C. Hepatic iron accumulation is generally increased in the chronic hepatitis C (CHC) liver; however, the precise mechanism of such accumulation remains unclear.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	103-111
30186818-0	2018	Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C. Hepatic iron accumulation is generally increased in the chronic hepatitis C (CHC) liver; however, the precise mechanism of such accumulation remains unclear.	Iron	158-162	solute carrier family 40 member 1	Homo sapiens	59-72
32118475-6	2019	Ferritin accumulated mainly on the edge of Abeta plaques, while the smaller amount of free iron was observed in the plaque-free tissue, as well as in and around Abeta plaques.	Iron	91-95	amyloid beta (A4) precursor protein	Mus musculus	161-166
30186818-13	2018	Lower serum hepcidin-25 levels might upregulate not only FPN protein expression but also mRNA expression in the duodenum and cause iron accumulation in patients with CHC.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	12-20
30096922-3	2018	Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR).	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	59-67
31882444-6	2020	cAMP increased intracellular labile Fe(II), the cofactor for histone demethylases, through a non-canonical cAMP target-Rap guanine nucleotide exchange factor-2 (RapGEF2), which subsequently enhanced endosome acidification and Fe(II) release from the endosome via vacuolar H+-ATPase assembly.	Iron	36-42	Rap guanine nucleotide exchange factor 2	Homo sapiens	112-159
30096922-5	2018	Systemic body iron release was defined as low levels of hepcidin (&lt;24 ng/mL) and high levels of sTfR (&gt;=2 mg/L).	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	56-64
30089125-5	2018	Systemic iron homeostasis is mainly regulated by the hepatic hormone hepcidin, which regulates the cell surface expression of the sole known iron exporter ferroportin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	69-77
31882444-6	2020	cAMP increased intracellular labile Fe(II), the cofactor for histone demethylases, through a non-canonical cAMP target-Rap guanine nucleotide exchange factor-2 (RapGEF2), which subsequently enhanced endosome acidification and Fe(II) release from the endosome via vacuolar H+-ATPase assembly.	Iron	36-42	Rap guanine nucleotide exchange factor 2	Homo sapiens	161-168
30089125-5	2018	Systemic iron homeostasis is mainly regulated by the hepatic hormone hepcidin, which regulates the cell surface expression of the sole known iron exporter ferroportin.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	69-77
31882444-6	2020	cAMP increased intracellular labile Fe(II), the cofactor for histone demethylases, through a non-canonical cAMP target-Rap guanine nucleotide exchange factor-2 (RapGEF2), which subsequently enhanced endosome acidification and Fe(II) release from the endosome via vacuolar H+-ATPase assembly.	Iron	226-232	Rap guanine nucleotide exchange factor 2	Homo sapiens	112-159
30089125-6	2018	The objective of this retrospective pilot study was to analyze the potential of hepcidin to predict the response of anemic patients to preoperative IV iron treatment measured as increase in Hgb.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	80-88
30089125-9	2018	The analysis revealed at first a correlation between serum hepcidin levels and the parameters of the iron status.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	59-67
31882444-6	2020	cAMP increased intracellular labile Fe(II), the cofactor for histone demethylases, through a non-canonical cAMP target-Rap guanine nucleotide exchange factor-2 (RapGEF2), which subsequently enhanced endosome acidification and Fe(II) release from the endosome via vacuolar H+-ATPase assembly.	Iron	226-232	Rap guanine nucleotide exchange factor 2	Homo sapiens	161-168
30159103-1	2018	Aims: Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron.	Iron	126-130	heme oxygenase 1	Homo sapiens	6-22
30159103-1	2018	Aims: Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron.	Iron	126-130	heme oxygenase 1	Homo sapiens	24-28
31881650-2	2019	Recently, two novel precursors, HCo 3 Fe(CO) 12 and Nb(NMe 3 ) 2 (N-t-Bu), were introduced, resulting in fully metallic CoFe ferromagnetic alloys by FEBID and superconducting NbC by FIBID, respectively.	Iron	120-124	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	55-60
31949415-12	2019	The increase of serum hepcidin levels may be inhibited by effective treatment of anemia with iron supplementation and erythropoietin, and the treatment of secondary hyperparathyroidism with phosphate binders and the active form of vitamin D, which decrease serum parathyroid hormone and fibroblast growth factor-23 levels, and control inflammation to some extent.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	22-30
29753142-3	2018	Heme oxygenase-1 (HO-1), an enzyme that catalyzes the degradation of heme to produce carbon monoxide (CO), biliverdin and ferrous iron (Fe2+), exerts anti-oxidant, antiinflammatory and anti-apoptotic properties.	Iron	130-134	heme oxygenase 1	Homo sapiens	0-16
29753142-3	2018	Heme oxygenase-1 (HO-1), an enzyme that catalyzes the degradation of heme to produce carbon monoxide (CO), biliverdin and ferrous iron (Fe2+), exerts anti-oxidant, antiinflammatory and anti-apoptotic properties.	Iron	130-134	heme oxygenase 1	Homo sapiens	18-22
31704097-5	2019	Accordingly, the phenotype of BVR-deficient cells can be mimicked by hemin or iron overload, whereas depletion of HO-1 in BVR-deficient ECs abrogates the increase in intracellular free iron and oxidative stress, preventing the loss of endothelial markers.	Iron	185-189	heme oxygenase 1	Homo sapiens	114-118
29939292-0	2018	Pea Ferritin Stability under Gastric pH Conditions Determines the Mechanism of Iron Uptake in Caco-2 Cells.	Iron	79-83	ferritin-1, chloroplastic	Glycine max	4-12
31704097-8	2019	Collectively, the non-enzymatic activity of BVR contributes to the maintenance of healthy endothelial phenotype through the prevention of HO-1-dependent iron-overload, oxidative stress and subsequent endothelial-to-mesenchymal transition (EndMT).	Iron	153-157	heme oxygenase 1	Homo sapiens	138-142
31735663-0	2019	Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export.	Iron	55-59	prominin 2	Homo sapiens	0-9
29939292-2	2018	Iron absorption from soybean-derived ferritin, an ~550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4).	Iron	0-4	ferritin-1, chloroplastic	Glycine max	37-45
29939292-2	2018	Iron absorption from soybean-derived ferritin, an ~550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4).	Iron	59-63	ferritin-1, chloroplastic	Glycine max	37-45
29939292-3	2018	However, the absorption of ferritin is reported to involve an endocytic mechanism, independent of divalent metal ion transporter 1 (DMT-1), the transporter for nonheme iron.	Iron	168-172	ferritin-1, chloroplastic	Glycine max	27-35
29939292-4	2018	Objective: Our overall aim was to examine the potential of purified ferritin from peas (Pisum sativum) as a food supplement by measuring its stability under gastric pH treatment and the mechanisms of iron uptake into Caco-2 cells.	Iron	200-204	ferritin-1, chloroplastic	Glycine max	68-76
29939292-8	2018	Results: Pea ferritin exposed to gastric pH treatment was degraded, and the released iron was transported into Caco-2 cells by DMT-1.	Iron	85-89	ferritin-1, chloroplastic	Glycine max	13-21
31735663-5	2019	Mechanistically, prominin2 promotes the formation of ferritin-containing multivesicular bodies (MVBs) and exosomes that transport iron out of the cell, inhibiting ferroptosis.	Iron	130-134	prominin 2	Homo sapiens	17-26
29939292-8	2018	Results: Pea ferritin exposed to gastric pH treatment was degraded, and the released iron was transported into Caco-2 cells by DMT-1.	Iron	85-89	solute carrier family 11 member 2	Homo sapiens	127-132
29939292-9	2018	Inhibitors of DMT-1 and nonheme iron absorption reduced iron uptake by 26-40%.	Iron	56-60	solute carrier family 11 member 2	Homo sapiens	14-19
30111424-5	2018	The expression level of platelet COX-1 positively correlated with those of Hb(r =0.623,P&lt;0.01),serum iron(r =0.321,P&lt;0.05) and HCT(r=0.305,P&lt;0.05).	Iron	104-108	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	33-38
29927450-1	2018	ZIP8 is a recently identified membrane transporter which facilitates uptake of many substrates including both essential and toxic divalent metals (e.g. zinc, manganese, iron, cadmium) and inorganic selenium.	Iron	169-173	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	0-4
29958803-0	2018	Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.	Iron	0-4	RNA binding motif single stranded interacting protein 3	Homo sapiens	53-72
29958803-2	2018	Here we showed that iron promoted proinflammatory cytokine expression in T cells, including GM-CSF and IL-2, via regulating the stability of an RNA-binding protein PCBP1.	Iron	20-24	colony stimulating factor 2	Homo sapiens	92-98
29958803-2	2018	Here we showed that iron promoted proinflammatory cytokine expression in T cells, including GM-CSF and IL-2, via regulating the stability of an RNA-binding protein PCBP1.	Iron	20-24	RNA binding motif single stranded interacting protein 3	Homo sapiens	144-163
29958803-3	2018	Iron depletion or Pcbp1 deficiency in T cells inhibited GM-CSF production by attenuating Csf2 3" untranslated region (UTR) activity and messenger RNA stability.	Iron	0-4	colony stimulating factor 2	Homo sapiens	56-62
29958803-3	2018	Iron depletion or Pcbp1 deficiency in T cells inhibited GM-CSF production by attenuating Csf2 3" untranslated region (UTR) activity and messenger RNA stability.	Iron	0-4	colony stimulating factor 2	Homo sapiens	89-93
29878770-4	2018	Investigation of pyrazoles, especially N-alkyl pyrazoles, as a new template to coordinate the heme-iron motif led to a potent and highly selective CYP11B2 inhibitor 28 with an aldosterone-lowering effect at 1 mg/kg dosing in cynomolgus monkeys.	Iron	99-103	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	147-154
29773647-2	2018	Erg25 is an iron-containing C4-methyl sterol oxidase that contributes to the conversion of 4,4-dimethylzymosterol to zymosterol, a precursor of ergosterol.	Iron	12-16	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	0-5
29773647-5	2018	Down-regulation of ERG29 expression in Deltaerg29 cells indeed led to accumulation of methyl sterol metabolites, resulting in increased mitochondrial oxidants and a decreased ability of mitochondria to synthesize iron-sulfur (Fe-S) clusters due to reduced levels of Yfh1, the mammalian frataxin homolog, which is involved in mitochondrial iron metabolism.	Iron	213-217	Erg29p	Saccharomyces cerevisiae S288C	19-24
29773647-5	2018	Down-regulation of ERG29 expression in Deltaerg29 cells indeed led to accumulation of methyl sterol metabolites, resulting in increased mitochondrial oxidants and a decreased ability of mitochondria to synthesize iron-sulfur (Fe-S) clusters due to reduced levels of Yfh1, the mammalian frataxin homolog, which is involved in mitochondrial iron metabolism.	Iron	226-230	Erg29p	Saccharomyces cerevisiae S288C	19-24
29773647-5	2018	Down-regulation of ERG29 expression in Deltaerg29 cells indeed led to accumulation of methyl sterol metabolites, resulting in increased mitochondrial oxidants and a decreased ability of mitochondria to synthesize iron-sulfur (Fe-S) clusters due to reduced levels of Yfh1, the mammalian frataxin homolog, which is involved in mitochondrial iron metabolism.	Iron	339-343	Erg29p	Saccharomyces cerevisiae S288C	19-24
31735663-6	2019	These findings reveal that ferroptosis resistance can be driven by a prominin2-MVB-exosome-ferritin pathway and have broad implications for iron homeostasis, intracellular trafficking, and cancer.	Iron	140-144	prominin 2	Homo sapiens	69-78
31660701-3	2019	We took a new approach to investigating an existing mouse mutant of Pank2 and found that isolating the disease-vulnerable brain revealed regional perturbations in CoA metabolism, iron homeostasis, and dopamine metabolism and functional defects in complex I and pyruvate dehydrogenase.	Iron	179-183	pantothenate kinase 2	Mus musculus	68-73
30095041-3	2019	Apolipoprotein E and Glutathione S-transferase act as the scavenger of free radicals, which are generated due to excess iron.	Iron	120-124	glutathione S-transferase kappa 1	Homo sapiens	21-46
31663684-8	2019	We have also proposed a method, in this work, to construct a residually stressed FE model so that the consequences of residual stresses on GI mechanics can be examined.	Iron	81-83	G protein subunit alpha i1	Homo sapiens	139-141
31663684-9	2019	Our FE formulation was able to capture the nonlinear soft tissue properties and also demonstrated that the addition of residual stresses reduces stress concentrations and the stress gradient in the GI wall.	Iron	4-6	G protein subunit alpha i1	Homo sapiens	198-200
31373375-0	2019	High Dietary Iron Disrupts Iron Homeostasis and Induces Amyloid-beta and Phospho-tau Expression in the Hippocampus of Adult Wild-Type and APP/PS1 Transgenic Mice.	Iron	13-17	presenilin 1	Mus musculus	142-145
31373375-10	2019	RESULTS: In the hippocampus, APP/PS1-High Fe mice had significantly higher iron concentration (2.5-fold) and ferritin (2.0-fold) than APP/PS1-Ctrl mice (P < 0.001), and WT-High Fe mice had significantly higher ferritin (2.0-fold) than WT-Ctrl mice (P < 0.001).	Iron	42-44	presenilin 1	Mus musculus	33-36
31525623-11	2019	Glutathione peroxidase (GPx) enzyme activities significantly increased in all groups, while glutathione S-transferase (GST) activity increased only in case of 0.87 and 30 mug/mL iron administration.	Iron	178-182	hematopoietic prostaglandin D synthase	Rattus norvegicus	92-117
31525623-11	2019	Glutathione peroxidase (GPx) enzyme activities significantly increased in all groups, while glutathione S-transferase (GST) activity increased only in case of 0.87 and 30 mug/mL iron administration.	Iron	178-182	hematopoietic prostaglandin D synthase	Rattus norvegicus	119-122
31525623-13	2019	The expression and activity of acetylcholinesterase (AChE) were elevated at 3 mug/mL iron concentration.	Iron	85-89	acetylcholinesterase	Rattus norvegicus	31-51
31525623-13	2019	The expression and activity of acetylcholinesterase (AChE) were elevated at 3 mug/mL iron concentration.	Iron	85-89	acetylcholinesterase	Rattus norvegicus	53-57
31784520-0	2019	Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET.	Iron	44-48	1,4-alpha-glucan branching enzyme 1	Homo sapiens	0-25
31784520-0	2019	Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET.	Iron	44-48	CDGSH iron sulfur domain 1	Homo sapiens	95-103
31784520-6	2019	AGBE binds specifically to holo-IRP1 and to mitoNEET, a protein capable of repairing IRP1 iron-sulphur clusters.	Iron	90-94	1,4-Alpha-Glucan Branching Enzyme	Drosophila melanogaster	0-4
31784520-6	2019	AGBE binds specifically to holo-IRP1 and to mitoNEET, a protein capable of repairing IRP1 iron-sulphur clusters.	Iron	90-94	CDGSH iron sulfur domain 1	Homo sapiens	44-52
31543462-2	2019	Accumulated evidence has revealed that hepcidin, the master regulator of iron homeostasis, is negatively modulated by TMPRSS6 (matriptase-2), a liver-specific type II transmembrane serine protease (TTSP).	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	39-47
31725784-5	2019	The mineral absorption pathway genes, HMOX1 and VDR are involved in iron metabolism and response to vitamin D, respectively.	Iron	68-72	heme oxygenase 1	Homo sapiens	38-43
31594301-7	2019	The coadministration of an iron chelator weakened the antitumor potency of the nanocarrier due to ferroptosis inhibition, which was supported by the fact of tumor growth upsurge and the recovered GPX4 activity.	Iron	27-31	glutathione peroxidase 4	Mus musculus	196-200
31700042-8	2019	In conclusion, a decrease in hepcidin concentration during the transition from the hypothyroid state to euthyroidism in patients with HT is associated with the observed dynamics in iron homeostasis, mainly reflected by improvement in RDW-CV and significant correlations between ferritin and hepcidin as well as between hepcidin and fT3.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	29-37
31542426-14	2019	And the expression of Bax was up-regulated and Bcl-2 was down-regulated in iron deposition groups.	Iron	75-79	BCL2 associated X, apoptosis regulator	Rattus norvegicus	22-25
31034252-1	2019	Hepcidin, a peptide hormone with an acknowledged evolutionary function in iron homeostasis, was discovered at the turn of the 21st century.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	0-8
31034252-3	2019	Such implications are particularly relevant in the sporting community where peaks in hepcidin postexercise (~3-6 hr) are suggested to reduce iron absorption and recycling, and contribute to the development of exercise-induced iron deficiency in athletes.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	85-93
31507082-10	2019	Ferritin heavy chain 1 (FTH1) and transferrin receotor protein 1 (TFR1), both of which are critical for iron metabolism, were markedly up-regulated in HCC cells treated with erastin and sorafenib, whereas knockdown of S1R inhibited these increases.	Iron	104-108	ferritin heavy chain 1	Homo sapiens	0-22
31507082-10	2019	Ferritin heavy chain 1 (FTH1) and transferrin receotor protein 1 (TFR1), both of which are critical for iron metabolism, were markedly up-regulated in HCC cells treated with erastin and sorafenib, whereas knockdown of S1R inhibited these increases.	Iron	104-108	ferritin heavy chain 1	Homo sapiens	24-28
31626992-0	2019	Site-specific intestinal DMT1 silencing to mitigate iron absorption using pH-sensitive multi-compartmental nanoparticulate oral delivery system.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	25-29
31626992-3	2019	While the divalent metal transporter 1 (DMT1) plays a well-established role in the absorption of dietary iron, up-regulation of intestinal DMT1 is associated with iron overload in both humans and rodents.	Iron	105-109	solute carrier family 11 member 2	Homo sapiens	10-38
31626992-3	2019	While the divalent metal transporter 1 (DMT1) plays a well-established role in the absorption of dietary iron, up-regulation of intestinal DMT1 is associated with iron overload in both humans and rodents.	Iron	105-109	solute carrier family 11 member 2	Homo sapiens	40-44
31626992-3	2019	While the divalent metal transporter 1 (DMT1) plays a well-established role in the absorption of dietary iron, up-regulation of intestinal DMT1 is associated with iron overload in both humans and rodents.	Iron	163-167	solute carrier family 11 member 2	Homo sapiens	139-143
31626992-5	2019	Using the gelatin NPs coated with Eudragit  L100-55, we demonstrated that DMT1 siRNA-loaded MCPs down-regulated DMT1 mRNA levels in the duodenum, which was consistent with decreased intestinal absorption of orally-administered 59Fe.	Iron	227-231	solute carrier family 11 member 2	Homo sapiens	74-78
31439810-4	2019	A recent RNA article identified both miR-7-5p and miR-141-3p as mediators of TfR1 mRNA degradation during iron-repletion.	Iron	106-110	microRNA 7-3	Homo sapiens	37-45
31644557-7	2019	The most substantial difference between genotypes was found in Fe in the older animals, where, across many regions examined, there was elevated Fe in the NFL knockout mice.	Iron	144-146	neurofilament, light polypeptide	Mus musculus	154-157
31628297-13	2019	CONCLUSIONS Qizhufang (ZSF) can ameliorate iron overload-induced injury by suppressing hepcidin via the STAT3 pathway in LO2 cells.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	87-95
31658742-2	2019	Synchrotron X-ray techniques, coupled with ultrahigh-resolution mass spectrometry, have been applied to study iron and copper interactions with amyloid beta (1-42) or alpha-synuclein.	Iron	110-114	synuclein alpha	Homo sapiens	167-182
31649559-1	2019	Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte production.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
31649559-2	2019	High hepcidin levels block intestinal iron absorption and macrophage iron recycling, causing iron restricted erythropoiesis and anemia.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	5-13
31649559-2	2019	High hepcidin levels block intestinal iron absorption and macrophage iron recycling, causing iron restricted erythropoiesis and anemia.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	5-13
31649559-2	2019	High hepcidin levels block intestinal iron absorption and macrophage iron recycling, causing iron restricted erythropoiesis and anemia.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	5-13
31649559-3	2019	Low hepcidin levels favor bone marrow iron supply for hemoglobin synthesis and red blood cells production.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	4-12
31649559-6	2019	Deregulation of hepcidin synthesis is associated with anemia in three conditions: iron refractory iron deficiency anemia (IRIDA), the common anemia of acute and chronic inflammatory disorders, and the extremely rare hepcidin-producing adenomas that may develop in the liver of children with an inborn error of glucose metabolism.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	16-24
31649559-6	2019	Deregulation of hepcidin synthesis is associated with anemia in three conditions: iron refractory iron deficiency anemia (IRIDA), the common anemia of acute and chronic inflammatory disorders, and the extremely rare hepcidin-producing adenomas that may develop in the liver of children with an inborn error of glucose metabolism.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	16-24
31649559-7	2019	Inappropriately high levels of hepcidin cause iron-restricted or even iron-deficient erythropoiesis in all these conditions.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	31-39
31649559-10	2019	Other hepcidin-related anemias are the "iron loading anemias" characterized by ineffective erythropoiesis and hepcidin suppression.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	6-14
31649559-10	2019	Other hepcidin-related anemias are the "iron loading anemias" characterized by ineffective erythropoiesis and hepcidin suppression.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	110-118
31649559-16	2019	Correcting ineffective erythropoiesis in animal models ameliorates not only anemia but also iron homeostasis by reducing hepcidin inhibition.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	121-129
31597407-7	2019	Moreover, most of the enzymes and proteins that cascade or interact in the pathway of ferroptosis such as a subunit of the cystine/glutamate transporter xc- (SLC7A11), glutathione peroxidase 4 (GPX4), and the glutamate-cysteine ligase (GCLC) iron metabolism genes transferrin receptor 1 (TfR1) ferroportin, (Fpn) heme oxygenase 1 (HO-1) and ferritin are regulated by the antioxidant response element of the transcription factor, Nrf2.	Iron	242-246	solute carrier family 7 member 11	Homo sapiens	158-165
31597407-7	2019	Moreover, most of the enzymes and proteins that cascade or interact in the pathway of ferroptosis such as a subunit of the cystine/glutamate transporter xc- (SLC7A11), glutathione peroxidase 4 (GPX4), and the glutamate-cysteine ligase (GCLC) iron metabolism genes transferrin receptor 1 (TfR1) ferroportin, (Fpn) heme oxygenase 1 (HO-1) and ferritin are regulated by the antioxidant response element of the transcription factor, Nrf2.	Iron	242-246	glutathione peroxidase 4	Homo sapiens	194-198
31368012-2	2019	Divalent metal-ion transporter (DMT1) is the major iron importer in enterocytes and erythroblasts.	Iron	51-55	solute carrier family 11 member 2	Homo sapiens	32-36
31172340-3	2019	The major regulator of iron homeostasis is the peptide hormone hepcidin.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	63-71
31172340-4	2019	Hepcidin expression is triggered by inflammatory conditions, which may contribute to the neuronal iron accumulation.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
31593159-3	2019	As in other cells, there is here a complex, local and autonomous regulation of iron metabolism, based on two molecular systems: the hepcidin/ferroportin/transferrin receptor-1 axis; and the iron regulatory proteins-1,2 system.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	132-140
31542425-5	2019	One of these carriers (TbMCP17) displayed high similarity with the iron carriers MRS3, MRS4 from yeast and mitoferrin from mammals, insects and plants.	Iron	67-71	Fe(2+) transporter	Saccharomyces cerevisiae S288C	87-91
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	12-16	cystathionine beta-synthase	Mus musculus	118-121
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	12-16	cystathionine beta-synthase	Mus musculus	132-135
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	101-105	cystathionine beta-synthase	Mus musculus	118-121
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	101-105	cystathionine beta-synthase	Mus musculus	132-135
31421070-6	2019	In fact, HO1, NADPH-cytochrome P450 reductase, and PCBP2 form a functional unit that integrates the catabolism of heme with the binding and transport of iron by PCBP2.	Iron	153-157	heme oxygenase 1	Homo sapiens	9-12
30886682-9	2018	Conclusion: Increased SN echogenicity and increased third ventricle diameter in GBA mutation carriers may be caused by alterations in iron metabolism with reference to their genetic status.	Iron	134-138	glucosylceramidase beta	Homo sapiens	80-83
31510077-6	2019	Transcriptome sequencing revealed the major effects of iron to be on signaling by the transforming growth factor beta (TGF-beta) pathway, a known mechanistic factor in NASH.	Iron	55-59	transforming growth factor alpha	Mus musculus	119-127
29942950-0	2018	Fe-doped CoP nanosheet arrays: an efficient bifunctional catalyst for zinc-air batteries.	Iron	0-2	caspase recruitment domain family member 16	Homo sapiens	9-12
29942950-2	2018	In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media.	Iron	38-40	caspase recruitment domain family member 16	Homo sapiens	47-50
29942950-2	2018	In this communication, we report that Fe-doped CoP nanosheet arrays on nickel foam (Fe0.33-CoP/NF) act as a highly active bifunctional electrocatalyst for both the oxygen reduction reaction and the oxygen evolution reaction in alkaline media.	Iron	38-40	caspase recruitment domain family member 16	Homo sapiens	91-94
30146840-9	2018	In iron overload thalassemia groups, expression levels of erythropoietin and ferritin were increased, but hepcidin and transferrin were significantly reduced.	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	106-114
31315930-1	2019	Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
29721769-2	2018	Human serum albumin (HSA) binds to heme via hydrophobic interactions and axial coordination of the iron center by protein residue Tyr161.	Iron	99-103	albumin	Bos taurus	6-19
31229492-8	2019	ROS produced by iron activates various signalling pathways, including mitogen-activated protein kinase (MAPK) signalling pathways such as the apoptosis signal-regulating kinase 1 (ASK1)-p38/JNK pathway.	Iron	16-20	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	142-178
29594459-6	2018	Hepcidin mRNA expression increased in response to iron administration in healthy Egyptian fruit bats and common vampire bats, but not in straw-colored fruit bats or Egyptian fruit bats with hemochromatosis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
29594459-7	2018	Hepcidin gene expression significantly correlated with liver iron content in Egyptian fruit bats and common vampire bats, and with transferrin saturation and plasma ferritin concentration in Egyptian fruit bats.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
29594459-8	2018	Induction of hepcidin gene expression in response to iron challenge is absent in straw-colored fruit bats and in Egyptian fruit bats with hemochromatosis and, relative to common vampire bats and healthy humans, is low in Egyptain fruit bats without hemochromatosis.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	13-21
31229492-8	2019	ROS produced by iron activates various signalling pathways, including mitogen-activated protein kinase (MAPK) signalling pathways such as the apoptosis signal-regulating kinase 1 (ASK1)-p38/JNK pathway.	Iron	16-20	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	180-184
29594459-9	2018	Limited hepcidin response to iron challenge may contribute to the increased susceptibility of Egyptian fruit bats to iron storage disease.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	8-16
29594459-9	2018	Limited hepcidin response to iron challenge may contribute to the increased susceptibility of Egyptian fruit bats to iron storage disease.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	8-16
31229649-10	2019	We speculate that this process of dZIP13 regulation, and that of IRE/IRP-controlled ferritin production, work together to better cope with iron repletion in the fly.	Iron	139-143	Iron regulatory protein 1B	Drosophila melanogaster	69-72
31229649-10	2019	We speculate that this process of dZIP13 regulation, and that of IRE/IRP-controlled ferritin production, work together to better cope with iron repletion in the fly.	Iron	139-143	Ferritin 2 light chain homologue	Drosophila melanogaster	84-92
30661261-5	2019	In this study, we set out to examine the link between the inflammatory, metabolic and iron-retentive signature of microglia in vitro and in transgenic mice that overexpress the amyloid precursor protein (APP) and presenilin 1 (PS1; APP/PS1 mice), a commonly used animal model of AD.	Iron	86-90	presenilin 1	Mus musculus	213-225
29776718-0	2018	High urinary ferritin reflects myoglobin iron evacuation in DMD patients.	Iron	41-45	myoglobin	Homo sapiens	31-40
29776718-6	2018	Obtained data strongly suggest that elevated level of urinary ferritin is functionally linked to the renal management of myoglobin iron derived from leaky muscles of DMD patients.	Iron	131-135	myoglobin	Homo sapiens	121-130
30661261-6	2019	Stimulation of cultured microglia with interferon (IFN)gamma and amyloid-beta (Abeta) induced an inflammatory phenotype and switched the metabolic profile and iron handling of microglia so that the cells became glycolytic and iron retentive, and the phagocytic and chemotactic function of the cells was reduced.	Iron	159-163	amyloid beta (A4) precursor protein	Mus musculus	79-84
30661261-6	2019	Stimulation of cultured microglia with interferon (IFN)gamma and amyloid-beta (Abeta) induced an inflammatory phenotype and switched the metabolic profile and iron handling of microglia so that the cells became glycolytic and iron retentive, and the phagocytic and chemotactic function of the cells was reduced.	Iron	226-230	amyloid beta (A4) precursor protein	Mus musculus	79-84
30661261-7	2019	Analysis of APP/PS1 mice by magnetic resonance imaging (MRI) revealed genotype-related hypointense areas in the hippocampus consistent with iron deposition, and immunohistochemical analysis indicated that the iron accumulated in microglia, particularly in microglia that decorated Abeta deposits.	Iron	209-213	presenilin 1	Mus musculus	16-19
29795199-1	2018	BACKGROUND: Hepcidin is a master regulator of iron metabolism.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	12-20
30661261-7	2019	Analysis of APP/PS1 mice by magnetic resonance imaging (MRI) revealed genotype-related hypointense areas in the hippocampus consistent with iron deposition, and immunohistochemical analysis indicated that the iron accumulated in microglia, particularly in microglia that decorated Abeta deposits.	Iron	209-213	amyloid beta (A4) precursor protein	Mus musculus	281-286
30661261-8	2019	Isolated microglia prepared from APP/PS1 mice were characterized by a switch to a glycolytic and iron-retentive phenotype and phagocytosis of Abeta was reduced in these cells.	Iron	97-101	presenilin 1	Mus musculus	37-40
31125881-0	2019	Fe-based ceramic nanocomposite membranes fabricated via e-spinning and vacuum filtration for Cd2+ ions removal.	Iron	0-2	CD2 molecule	Homo sapiens	93-96
30182051-5	2018	Our aim was to assess the effects of combined deletion of HEPH and CP on intestinal iron absorption and homeostasis in mice.	Iron	84-88	ceruloplasmin	Mus musculus	67-69
30182051-10	2018	Conclusions: These studies indicate that HEPH and CP, and likely MCFs in general, are not essential for intestinal iron absorption but are required for proper systemic iron distribution.	Iron	168-172	ceruloplasmin	Mus musculus	50-52
31125881-1	2019	In this work, vacuum filtered and polymer mixed e-spinning membranes (ESPMs) made from or doped with Fe-based nanomaterials were successfully fabricated to remove Cd2+ ions from a neutral aqueous solution.	Iron	101-103	CD2 molecule	Homo sapiens	163-166
31552828-2	2019	Hepcidin is a key negative regulator of iron homeostasis and functions.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
29735522-2	2018	Mammalian hosts respond to infection by inducing the iron-regulatory hormone hepcidin, which causes iron sequestration and a rapid decrease in the plasma and extracellular iron concentration (hypoferremia).	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	77-85
29735522-2	2018	Mammalian hosts respond to infection by inducing the iron-regulatory hormone hepcidin, which causes iron sequestration and a rapid decrease in the plasma and extracellular iron concentration (hypoferremia).	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	77-85
29735522-3	2018	Previous studies showed that hepcidin regulation of iron is essential for protection from infection-associated mortality with the siderophilic pathogens Yersinia enterocolitica and Vibrio vulnificus However, the evolutionary conservation of the hypoferremic response to infection suggests that not only rare siderophilic bacteria but also common pathogens may be targeted by this mechanism.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	29-37
29735522-4	2018	We tested 10 clinical isolates of Escherichia coli from children with sepsis and found that both genetic iron overload (by hepcidin-1 knockout [HKO]) and iatrogenic iron overload (by intravenous iron) potentiated infection with 8 out of the 10 studied isolates: after peritoneal injection of E. coli, iron-loaded mice developed sepsis with 60% to 100% mortality within 24 h, while control wild-type mice suffered 0% mortality.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	123-131
29735522-9	2018	The use of hepcidin agonists promises to be an effective early intervention in patients with infections and dysregulated iron metabolism.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	11-19
31350450-1	2019	OBJECTIVE: The reticulocyte index reticulocyte hemoglobin equivalent (Ret-He) was evaluated as a marker of iron status.	Iron	107-111	ret proto-oncogene	Homo sapiens	70-73
29912874-0	2018	Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency.	Iron	84-88	Tis11p	Saccharomyces cerevisiae S288C	6-10
29912874-4	2018	By complementary approaches, we demonstrate that Cth2 protein inhibits the translation of SDH4, which encodes a subunit of succinate dehydrogenase, and CTH2 mRNAs in response to iron depletion.	Iron	178-182	Tis11p	Saccharomyces cerevisiae S288C	49-53
29912874-4	2018	By complementary approaches, we demonstrate that Cth2 protein inhibits the translation of SDH4, which encodes a subunit of succinate dehydrogenase, and CTH2 mRNAs in response to iron depletion.	Iron	178-182	Tis11p	Saccharomyces cerevisiae S288C	152-156
31350450-7	2019	CONCLUSION: Ret-He values showed a slow uptrend with enteral iron supplementation following an initial decrease, suggesting that neonates are able to improve their iron sufficiency status with supplementation.	Iron	61-65	ret proto-oncogene	Homo sapiens	12-15
31350450-7	2019	CONCLUSION: Ret-He values showed a slow uptrend with enteral iron supplementation following an initial decrease, suggesting that neonates are able to improve their iron sufficiency status with supplementation.	Iron	164-168	ret proto-oncogene	Homo sapiens	12-15
31377220-7	2019	High levels of Cu, Mn and Fe participate in the formation alpha-synuclein aggregates in intracellular inclusions, called Lewy Body, that result in synaptic dysfunction and interruption of axonal transport.	Iron	26-28	synuclein alpha	Homo sapiens	58-73
29989073-0	2018	Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Trp53+/- Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?	Iron	23-27	transformation related protein 53	Mus musculus	69-74
29937728-10	2018	Overexpression of Ndfip1 down-regulated DMT1 expression, and reduced iron influx and Abeta secretion in SH-SY5Y cells.	Iron	69-73	Nedd4 family interacting protein 1	Homo sapiens	18-24
31470556-0	2019	Multilevel Impacts of Iron in the Brain: The Cross Talk between Neurophysiological Mechanisms, Cognition, and Social Behavior.	Iron	22-26	bone morphogenetic protein receptor type 2	Homo sapiens	51-55
29874829-5	2018	It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN).	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	198-206
29874829-5	2018	It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN).	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	198-206
29874829-5	2018	It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN).	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	198-206
29874829-5	2018	It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN).	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	198-206
31450766-1	2019	Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to alpha2-macroglobulin and albumin in blood.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	16-24
29745043-1	2018	Hepcidin is crucial in regulating iron metabolism, and increased serum levels were strongly linked with poor outcomes in various malignancies.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
31434871-7	2019	Interestingly, in FAC-exposed FTSECs, EVI1 siRNA attenuated hTERT mRNA expression, whereas siRNAs targeting beta-catenin and BMI1 (both elevated with chronic iron exposure) reduced Myc and Cyclin D1 proteins.	Iron	158-162	catenin beta 1	Homo sapiens	108-120
29279245-0	2018	An optimized low-cost protocol for standardized production of iron-free apoferritin nanocages with high protein recovery and suitable conformation for nanotechnological applications.	Iron	62-66	ferritin heavy chain 1	Homo sapiens	72-83
29279245-2	2018	Elimination of iron atoms to obtain the empty protein called apoferritin is the first step to use this organic shell as a nanoreactor for different nanotechnological applications.	Iron	15-19	ferritin heavy chain 1	Homo sapiens	61-72
31434871-7	2019	Interestingly, in FAC-exposed FTSECs, EVI1 siRNA attenuated hTERT mRNA expression, whereas siRNAs targeting beta-catenin and BMI1 (both elevated with chronic iron exposure) reduced Myc and Cyclin D1 proteins.	Iron	158-162	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	181-184
31430278-5	2019	Mutation of JMJD6 amino acids that mediate binding of iron and 2-oxogluterate, which are required cofactors for enzymatic activity, had no impact on JMJD6 function, showing that catalytic activity is not required for JMJD6 contributions to adipogenic differentiation.	Iron	54-58	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	12-17
29500821-8	2018	Hpx weakly attenuated the increase in culture non-heme iron produced by Hb treatment, quantified by ferrozine assay.	Iron	55-59	hemopexin	Mus musculus	0-3
29500821-9	2018	However, Hb-Hpx toxicity was iron-dependent, and was blocked by deferoxamine and ferrostatin-1.	Iron	29-33	hemopexin	Mus musculus	12-15
29500821-11	2018	These results suggest that Hpx destabilizes Hb in the absence of haptoglobin, leading to globin precipitation and exacerbation of iron-dependent oxidative cell injury.	Iron	130-134	hemopexin	Mus musculus	27-30
31531185-13	2019	FE treatment of UVB-irradiated skin increased dermal thickness and capillary density, decreased the number of apoptotic cells, and promoted the expression of COL-1 and GPX-1.	Iron	0-2	glutathione peroxidase 1	Mus musculus	168-173
29844842-8	2018	Furthermore, the iron levels of hepcidin-silenced cells (hepcidin-ve groups) were significantly lower than those in the cells treated with exogenous hepcidin (hepcidin+ve groups) (P&lt;0.05).	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	32-40
29844842-8	2018	Furthermore, the iron levels of hepcidin-silenced cells (hepcidin-ve groups) were significantly lower than those in the cells treated with exogenous hepcidin (hepcidin+ve groups) (P&lt;0.05).	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	57-65
29844842-8	2018	Furthermore, the iron levels of hepcidin-silenced cells (hepcidin-ve groups) were significantly lower than those in the cells treated with exogenous hepcidin (hepcidin+ve groups) (P&lt;0.05).	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	57-65
29844842-8	2018	Furthermore, the iron levels of hepcidin-silenced cells (hepcidin-ve groups) were significantly lower than those in the cells treated with exogenous hepcidin (hepcidin+ve groups) (P&lt;0.05).	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	57-65
29844842-12	2018	Hepcidin is involved in the onset of prostate cancer, most likely by reducing ferroportin expression and increasing intracellular iron levels to enhance the proliferation, migration and anti-apoptotic capacities of cancer cells.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	0-8
29607597-4	2018	We isolated and structurally characterized a Bi/Fe cluster, Fe3 BiO2 (CCl3 COO)8 (THF)(H2 O)2 , and demonstrated its conversion into an iron Keggin ion capped by six Bi3+ irons (Bi6 Fe13 ).	Iron	48-50	C-C motif chemokine ligand 3	Homo sapiens	70-74
29580991-3	2018	Recently, ferritin heavy chain (FTH1) has been characterized to reinforce the HIF-1 signaling pathway in an indirect way through the inhibition of PHD activity by depleting the free iron pool in the cytoplasm.	Iron	182-186	ferritin heavy chain 1	Homo sapiens	10-30
29580991-3	2018	Recently, ferritin heavy chain (FTH1) has been characterized to reinforce the HIF-1 signaling pathway in an indirect way through the inhibition of PHD activity by depleting the free iron pool in the cytoplasm.	Iron	182-186	ferritin heavy chain 1	Homo sapiens	32-36
28874056-1	2018	AIMS: Ceruloplasmin (CP), a ferrous oxidase enzyme, plays an important role in regulating iron metabolism and redox reactions.	Iron	90-94	ceruloplasmin	Mus musculus	6-19
28874056-1	2018	AIMS: Ceruloplasmin (CP), a ferrous oxidase enzyme, plays an important role in regulating iron metabolism and redox reactions.	Iron	90-94	ceruloplasmin	Mus musculus	21-23
28874056-4	2018	We hypothesized that the lack of CP gene expression would affect the pathogenesis and damage of AD by promoting abnormal iron levels and oxidative stress.	Iron	121-125	ceruloplasmin	Mus musculus	33-35
28874056-7	2018	Compared to control AD mice, CP gene deletion increased memory impairment and iron accumulation, which could be associated with elevated reactive oxygen species (ROS) levels and lead to cell apoptosis mediated through the Bcl-2/Bax and Erk/p38 signaling pathways in Abeta-CP-/- and APP-CP-/- mice.	Iron	78-82	ceruloplasmin	Mus musculus	29-31
29734693-0	2018	Iron Release from Soybean Seed Ferritin Induced by Cinnamic Acid Derivatives.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	31-39
29734693-1	2018	Plant ferritin represents a novel class of iron supplement, which widely co-exists with phenolic acids in a plant diet.	Iron	43-47	ferritin-1, chloroplastic	Glycine max	6-14
29734693-3	2018	In this study, we demonstrated that cinnamic acid derivatives, as widely occurring phenolic acids, can induce iron release from holo soybean seed ferritin (SSF) in a structure-dependent manner.	Iron	110-114	ferritin-1, chloroplastic	Glycine max	146-154
29734693-6	2018	In contrast, both Fe2+-chelating activity and reducibility of these cinnamic acid derivatives are in good agreement with their ability to induce iron release from ferritin.	Iron	145-149	ferritin-1, chloroplastic	Glycine max	163-171
29734693-7	2018	These studies indicate that cinnamic acid and its derivatives could have a negative effect on iron stability of holo soybean seed ferritin in diet, and the Fe2+-chelating activity and reducibility of cinnamic acid and its derivatives have strong relations to the iron release of soybean seed ferritin.	Iron	94-98	ferritin-1, chloroplastic	Glycine max	130-138
29725013-0	2018	Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.	Iron	0-4	mitochondrial fission factor	Homo sapiens	150-153
29725013-0	2018	Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.	Iron	0-4	dynamin 1 like	Homo sapiens	154-158
29725013-11	2018	In addition, iron chelation or antioxidant weakened the activity of the AMPK/MFF/Drp1 pathway in MDS-MSCs with IO from several patients, accompanied by attenuation of mitochondrial fragmentation and autophagy.	Iron	13-17	mitochondrial fission factor	Homo sapiens	77-80
29725013-11	2018	In addition, iron chelation or antioxidant weakened the activity of the AMPK/MFF/Drp1 pathway in MDS-MSCs with IO from several patients, accompanied by attenuation of mitochondrial fragmentation and autophagy.	Iron	13-17	dynamin 1 like	Homo sapiens	81-85
29722188-2	2018	The disease is characterised by an inappropriate increase in intestinal iron absorption due to reduced expression of the iron regulatory protein, hepcidin.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	146-154
29685625-0	2018	Increased serum iron in preeclamptic women is likely due to low hepcidin levels.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	64-72
29685625-2	2018	To test the hypothesis that increased serum iron in women diagnosed with preeclampsia results from decreased production of hepcidin, we performed an observational case-control study in which serum hepcidin concentration, dietary iron intake, hematological indices, iron status, liver function, and inflammatory markers in 18 preeclamptic women and 18 healthy normotensive pregnant women of similar age range were evaluated.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	123-131
29685625-9	2018	We conclude that high serum iron in preeclamptic women is likely caused by low production of hepcidin, thus supporting the hypothesis originally stated.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	93-101
29636422-4	2018	LTF (lactoferrin) is an iron-binding protein, uniquely abundant in polymorphonuclear neutrophils (PMNs).	Iron	24-28	lactotransferrin	Mus musculus	0-3
29636422-4	2018	LTF (lactoferrin) is an iron-binding protein, uniquely abundant in polymorphonuclear neutrophils (PMNs).	Iron	24-28	lactotransferrin	Mus musculus	5-16
29636422-6	2018	By virtue of sequestrating iron, LTF may contribute to hematoma detoxification.	Iron	27-31	lactotransferrin	Mus musculus	33-36
29677205-12	2018	Increased hepcidin levels long before active disease, indicating altered iron metabolism, may be a marker for developing disease among TB-exposed individuals.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	10-18
29620054-1	2018	Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in hepcidin-ferroportin binding.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	147-155
29620054-1	2018	Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in hepcidin-ferroportin binding.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	147-155
29620054-2	2018	Hepcidin regulates the activity of ferroportin, which is the only identified cellular iron exporter.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	0-8
28875299-3	2018	The 2 enzymes have been found to interact with Myb transcription factors in the parasite which regulate the iron induced expression of ap65-1 gene leading to cytoadherence of the parasite to human vaginal epithelial cells to cause the disease trichomoniasis.	Iron	108-112	MYB proto-oncogene, transcription factor	Homo sapiens	47-50
28662967-2	2018	The discovery of hepcidin as the prime controller of iron metabolism has paved the way for understanding the main actors behind this mediation.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	17-25
28662967-3	2018	Recent data suggest that insulin therapy and probably other diabetes drugs can influence hepcidin production, thus influencing the iron load in cells.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	89-97
28662967-4	2018	Correcting iron load through hepcidin expression could be a novel and important mechanism of action of antidiabetes drugs.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	29-37
28871473-3	2018	Accordingly, in this study, we aimed to investigate the effects of Prdx2 on iron-induced cytotoxicity using an in vitro model in which PC12 cells are exposed to ferrous sulfate (FS).	Iron	76-80	peroxiredoxin 2	Rattus norvegicus	67-72
28871473-7	2018	In conclusion, our findings demonstrated that Prdx2 played a vital role in the protection against iron-induced cytotoxicity in PC12 cells.	Iron	98-102	peroxiredoxin 2	Rattus norvegicus	46-51
29043483-6	2018	Transcription of yeast CCC1 expression is tightly controlled primarily by the transcription factor Yap5, which sits on the CCC1 promoter and activates transcription through the binding of Fe-S clusters.	Iron	188-192	Yap5p	Saccharomyces cerevisiae S288C	99-103
29291402-0	2018	CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.	Iron	42-46	DNA-damage inducible transcript 3	Rattus norvegicus	0-4
29291402-2	2018	Our research aims to investigate the role of CHOP-mediated iron metabolism in EBI after SAH and the underlying mechanism.	Iron	59-63	DNA-damage inducible transcript 3	Rattus norvegicus	45-49
29291402-13	2018	Thus, CHOP promotes hepcidin expression by regulating C/EBPalpha activity, which increases the brain iron content, induces apoptosis and is involved in the development of EBI after SAH.	Iron	101-105	DNA-damage inducible transcript 3	Rattus norvegicus	6-10
29291402-13	2018	Thus, CHOP promotes hepcidin expression by regulating C/EBPalpha activity, which increases the brain iron content, induces apoptosis and is involved in the development of EBI after SAH.	Iron	101-105	CCAAT/enhancer binding protein alpha	Rattus norvegicus	54-64
29659961-0	2018	Multi-Copper Ferroxidase-Deficient Mice Have Increased Brain Iron Concentrations and Learning and Memory Deficits.	Iron	61-65	ceruloplasmin	Mus musculus	13-24
29418021-12	2018	This result emphasizes the complex peripheral iron metabolism deregulation in restless legs syndrome, opening potential perspectives for a personalized approach with a hepcidin antagonist.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	168-176
29430595-1	2018	Hepcidin, the key hormone of iron homeostasis is responsible for lowering the serum iron level through its interaction with iron exporter ferroportin.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
29430595-1	2018	Hepcidin, the key hormone of iron homeostasis is responsible for lowering the serum iron level through its interaction with iron exporter ferroportin.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
29430595-1	2018	Hepcidin, the key hormone of iron homeostasis is responsible for lowering the serum iron level through its interaction with iron exporter ferroportin.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
29126071-8	2018	Interestingly, Tau-induced iron overload, lipid peroxidation, and inflammation, which are involved in ferroptosis, were significantly blocked by LA administration.	Iron	27-31	microtubule associated protein tau	Homo sapiens	15-18
31723763-2	2018	In mammalian systems, iron availability is controlled by the interaction of the iron-regulatory hormone hepcidin with ferroportin, a molecule that functions both as the hepcidin receptor as well as the sole known cellular exporter of iron.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	104-112
31723763-2	2018	In mammalian systems, iron availability is controlled by the interaction of the iron-regulatory hormone hepcidin with ferroportin, a molecule that functions both as the hepcidin receptor as well as the sole known cellular exporter of iron.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	169-177
31723763-2	2018	In mammalian systems, iron availability is controlled by the interaction of the iron-regulatory hormone hepcidin with ferroportin, a molecule that functions both as the hepcidin receptor as well as the sole known cellular exporter of iron.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	104-112
31723763-2	2018	In mammalian systems, iron availability is controlled by the interaction of the iron-regulatory hormone hepcidin with ferroportin, a molecule that functions both as the hepcidin receptor as well as the sole known cellular exporter of iron.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	169-177
31723763-2	2018	In mammalian systems, iron availability is controlled by the interaction of the iron-regulatory hormone hepcidin with ferroportin, a molecule that functions both as the hepcidin receptor as well as the sole known cellular exporter of iron.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	104-112
31723763-2	2018	In mammalian systems, iron availability is controlled by the interaction of the iron-regulatory hormone hepcidin with ferroportin, a molecule that functions both as the hepcidin receptor as well as the sole known cellular exporter of iron.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	169-177
31723763-3	2018	By reducing iron export through ferroportin to blood plasma, hepcidin inhibits the mobilization of iron from stores and the absorption of dietary iron.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	61-69
31723763-3	2018	By reducing iron export through ferroportin to blood plasma, hepcidin inhibits the mobilization of iron from stores and the absorption of dietary iron.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	61-69
31723763-3	2018	By reducing iron export through ferroportin to blood plasma, hepcidin inhibits the mobilization of iron from stores and the absorption of dietary iron.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	61-69
29507250-3	2018	Analysis of mutant enterocytes demonstrates that modulation of their substrate 3"-phosphoadenosine 5"-phosphate (PAP) influences levels of key iron homeostasis factors involved in dietary iron reduction, import and transport, that in part mimic those reported for the loss of hypoxic-induced transcription factor, HIF-2alpha.	Iron	143-147	endothelial PAS domain protein 1	Mus musculus	314-324
32254421-6	2018	Furthermore, the Fe-incorporated titanium substrates significantly enhanced the expressions of osteogenic genes (such as Runx2, Col I, OPN, and OCN), which were attributed to the synergistic effects of micro-nano structures and Fe ions.	Iron	17-19	secreted phosphoprotein 1	Homo sapiens	135-138
29544561-0	2018	Measurement of interaction behavior of six biologically important noble metal ions with the iron(III) binding protein, apo-transferrin, using mobility-shift affinity electrophoresis.	Iron	92-96	aminopeptidase O (putative)	Homo sapiens	119-122
29544561-2	2018	At saturation level 70% of transferrin remains free from iron (apo-transferrin), suggesting a broader scope of binding capabilities with non-iron (III) metal ions.	Iron	57-61	aminopeptidase O (putative)	Homo sapiens	63-66
29336855-6	2018	New insights into the dynamics of iron metabolism have clarified the role of chronic inflammation and hepcidin as key mediators of impaired iron utilization.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	102-110
29336855-6	2018	New insights into the dynamics of iron metabolism have clarified the role of chronic inflammation and hepcidin as key mediators of impaired iron utilization.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	102-110
29127238-0	2018	Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.	Iron	73-77	mechanistic target of rapamycin kinase	Mus musculus	26-57
29127238-12	2018	These findings suggest that ferroptosis is a significant type of cell death in CMs and that mTOR plays an important role in protecting CMs against excess iron and ferroptosis, at least in part, by regulating ROS production.	Iron	154-158	mechanistic target of rapamycin kinase	Mus musculus	92-96
29274359-8	2018	The ferroptotic process induced by hHO-1 overexpression further indicated that HO-1 is a key mediator of BAY-induced ferroptosis that operates through cellular redox regulation and iron accumulation.	Iron	181-185	heme oxygenase 1	Homo sapiens	35-40
29414037-5	2018	Moreover, it was found that [Fe-P1]2+ is a more stable complex than [Fe-DFP]2+ and [Fe-3,4-HOPO]2+ in the gas phase and water, confirming that P1 is the strongest selective iron chelator.	Iron	173-177	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	32-34
29414037-5	2018	Moreover, it was found that [Fe-P1]2+ is a more stable complex than [Fe-DFP]2+ and [Fe-3,4-HOPO]2+ in the gas phase and water, confirming that P1 is the strongest selective iron chelator.	Iron	173-177	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	143-145
29058707-1	2018	Hepcidin is the main regulator of iron metabolism in tissues.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
29410996-9	2018	Moreover, Grx5 in mitochondria contains a 2Fe-2S cluster stabilized by GSH, which can mediate cellular iron metabolism.	Iron	103-107	glutaredoxin 5	Homo sapiens	10-14
31723756-0	2018	The Iron Tale: If It Does Not Kill You, It Makes You Stronger (and Hepcidin Helps).	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	67-75
29282252-0	2018	Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.	Iron	0-4	erythropoietin receptor	Homo sapiens	86-109
29282252-5	2018	Our results reveal that iron restriction limits surface display of Epo receptor in primary progenitors and that mice with enforced surface retention of the receptor fail to develop anemia with iron deprivation.	Iron	24-28	erythropoietin	Mus musculus	67-70
29282252-6	2018	A mechanistic pathway is identified in which erythroid iron restriction down-regulates a receptor control element, Scribble, through the mediation of the iron-sensing transferrin receptor 2.	Iron	55-59	transferrin receptor 2	Homo sapiens	167-189
29154924-1	2018	Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations.	Iron	69-73	solute carrier family 40 member 1	Homo sapiens	13-20
29154924-1	2018	Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	13-20
29154924-1	2018	Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	13-20
29208364-5	2018	The expansion of intracellular iron upon dopamine treatment resulted in oxidative stress responses as evidenced by increased expression of nuclear factor erythroid 2-related factor (Nrf2) and hypoxia inducible factor-1alpha.	Iron	31-35	hypoxia inducible factor 1, alpha subunit	Mus musculus	192-223
29091852-4	2018	Scanning electron microscope (SEM), nitrogen adsorption, Fourier transform infrared spectroscopy (FTIR) and microbial analysis indicated that magnetite enriched iron-reducing bacteria responsible for sludge hydrolysis while GAC enhanced syntrophic metabolism between iron-reducing bacteria and methanogens due to its high electrical conductivity and large surface area.	Iron	267-271	glutaminase	Homo sapiens	224-227
29285662-8	2018	Additionally, Lf in bovine milk may bind heme directly, but may also bind heme indirectly by interaction with other milk iron- and/or heme-binding proteins.	Iron	121-125	lactotransferrin	Bos taurus	14-16
29113828-0	2018	Downregulation of BDH2 modulates iron homeostasis and promotes DNA demethylation in CD4+ T cells of systemic lupus erythematosus.	Iron	33-37	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	18-22
29113828-2	2018	Here we investigated whether 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis, was involved in regulating DNA hypomethylation and hyper-hydroxymethylation in lupus CD4+ T cells.	Iron	101-105	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	65-69
29113828-4	2018	The decreased BDH2 contributed to DNA hyper-hydroxymethylation and hypomethylation via increasing intracellular iron in CD4+ T cells, which led to overexpression of immune related genes.	Iron	112-116	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	14-18
29235098-1	2018	BACKGROUND: The liver hormone hepcidin regulates iron homoeostasis that is often altered in hepatocellular carcinoma (HCC).	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	30-38
29235098-10	2018	CONCLUSIONS: This study highlights a novel role for HAMP downregulation through DNA promoter hypermethylation and emphasises the significance of epigenetics in the regulation of iron metabolism in HCC.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	52-56
29165044-7	2018	The iron contents in the MCF-7 and CT-26 cells were 33.1 +- 1.8 and 27.9 +- 0.95 pg, respectively, after co-incubation with LyP-1-SPIONs for 8 h. The LyP-1-SPIONs accumulated in the nucleus of MCF-7 cells while PEG-SPIONs in cytoplasma.	Iron	4-8	progestagen associated endometrial protein	Homo sapiens	211-214
31412634-7	2019	Studies in intestinal cell culture models demonstrate that zinc induces iron uptake and transcellular transport via induction of divalent metal iron transporter-1 (DMT1) and ferroportin (FPN1) expression, respectively.	Iron	72-76	solute carrier family 11 member 2	Homo sapiens	164-168
29251628-5	2018	In mice, loss of receptor tyrosine kinases AXL and MERTK reduced efferocytosis of eryptotic erythrocytes and hematoma clearance, worsened neurological recovery, exacerbated iron deposition, and decreased alternative activation of macrophages after ICH.	Iron	173-177	AXL receptor tyrosine kinase	Mus musculus	43-46
29251628-5	2018	In mice, loss of receptor tyrosine kinases AXL and MERTK reduced efferocytosis of eryptotic erythrocytes and hematoma clearance, worsened neurological recovery, exacerbated iron deposition, and decreased alternative activation of macrophages after ICH.	Iron	173-177	MER proto-oncogene tyrosine kinase	Mus musculus	51-56
31412634-7	2019	Studies in intestinal cell culture models demonstrate that zinc induces iron uptake and transcellular transport via induction of divalent metal iron transporter-1 (DMT1) and ferroportin (FPN1) expression, respectively.	Iron	72-76	solute carrier family 40 member 1	Homo sapiens	187-191
29236334-2	2018	Hepcidin acts as a negative feedback iron regulator.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
31412634-9	2019	Therefore, zinc appears to be modulating the iron metabolism possibly via regulating the DMT1 and FPN1 levels.	Iron	45-49	solute carrier family 11 member 2	Homo sapiens	89-93
29236334-11	2018	Changes in hepcidin 5 days after transfusion were correlated significantly with changes in mean corpuscular hemoglobin (beta, 0.13; SE, 0.05; P = 0.017), total iron binding capacity (beta, 3.74; SE, 1.56; P = 0.016) and transferrin (beta, 2.9, SE, 1.4; P = 0.039).	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	11-19
29236334-12	2018	CONCLUSIONS: Serum hepcidin concentration, along with IRF and HLR, are potentially useful in estimating pre- and post-transfusion iron status.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	19-27
31412634-9	2019	Therefore, zinc appears to be modulating the iron metabolism possibly via regulating the DMT1 and FPN1 levels.	Iron	45-49	solute carrier family 40 member 1	Homo sapiens	98-102
29120522-1	2018	BACKGROUND: The liver-synthesized peptide hepcidin is a key regulator of iron metabolism and correlates with total iron stores.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	42-50
31412634-10	2019	Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.	Iron	132-136	solute carrier family 11 member 2	Homo sapiens	92-96
29120522-1	2018	BACKGROUND: The liver-synthesized peptide hepcidin is a key regulator of iron metabolism and correlates with total iron stores.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	42-50
31412634-10	2019	Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.	Iron	132-136	solute carrier family 40 member 1	Homo sapiens	97-101
29120522-10	2018	CONCLUSION: Elevated baseline serum hepcidin-25 levels were associated with increased risk of infection after KT, suggesting a role for iron overload in the individual susceptibility to post-transplant infection.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	36-44
31412634-10	2019	Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.	Iron	159-163	solute carrier family 11 member 2	Homo sapiens	92-96
31412634-10	2019	Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.	Iron	159-163	solute carrier family 40 member 1	Homo sapiens	97-101
31412634-10	2019	Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.	Iron	159-163	solute carrier family 11 member 2	Homo sapiens	92-96
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	interleukin 10	Rattus norvegicus	124-129
31412634-10	2019	Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.	Iron	159-163	solute carrier family 40 member 1	Homo sapiens	97-101
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	interleukin 10	Rattus norvegicus	151-156
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	interleukin 10	Rattus norvegicus	151-156
31406150-2	2019	Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in both MS patients and in the experimental autoimmune encephalomyelitis (EAE) model of MS. Divalent Metal Transporter1, a major iron importer in cells, is stimulated by signaling of Dexras1, a small G protein member of the Ras family.	Iron	0-4	ras related dexamethasone induced 1	Homo sapiens	312-319
29330517-12	2018	In conclusion, iron-induced calcification in vascular smooth muscle cells occurred via IL-24, IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron.	Iron	15-19	interleukin 24	Homo sapiens	87-92
29330517-12	2018	In conclusion, iron-induced calcification in vascular smooth muscle cells occurred via IL-24, IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron.	Iron	15-19	interleukin 24	Homo sapiens	94-99
29330517-12	2018	In conclusion, iron-induced calcification in vascular smooth muscle cells occurred via IL-24, IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron.	Iron	15-19	interleukin 24	Homo sapiens	94-99
29330517-12	2018	In conclusion, iron-induced calcification in vascular smooth muscle cells occurred via IL-24, IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron.	Iron	158-162	interleukin 24	Homo sapiens	94-99
29330517-12	2018	In conclusion, iron-induced calcification in vascular smooth muscle cells occurred via IL-24, IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron.	Iron	158-162	interleukin 24	Homo sapiens	94-99
29330517-12	2018	In conclusion, iron-induced calcification in vascular smooth muscle cells occurred via IL-24, IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron.	Iron	158-162	interleukin 24	Homo sapiens	94-99
29330517-12	2018	In conclusion, iron-induced calcification in vascular smooth muscle cells occurred via IL-24, IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron.	Iron	158-162	interleukin 24	Homo sapiens	94-99
29379774-9	2017	Nramp1 regulates iron efflux from the phagosomes, thus starving pathogenic bacteria for iron.	Iron	17-21	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
29379774-9	2017	Nramp1 regulates iron efflux from the phagosomes, thus starving pathogenic bacteria for iron.	Iron	88-92	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
29320706-0	2018	Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.	Iron	46-50	cytosolic iron-sulfur assembly component 2B	Homo sapiens	23-28
29320706-0	2018	Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.	Iron	46-50	cytosolic iron-sulfur assembly component 2B	Homo sapiens	29-35
29320706-0	2018	Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.	Iron	120-124	cytosolic iron-sulfur assembly component 2B	Homo sapiens	23-28
29354636-6	2017	In hIDO, by contrast, dioxygen must first coordinate to the heme iron because a bound substrate would occlude ligand access to the heme iron, so the ternary complex can no longer form.	Iron	65-69	indoleamine 2,3-dioxygenase 1	Homo sapiens	3-7
29354636-6	2017	In hIDO, by contrast, dioxygen must first coordinate to the heme iron because a bound substrate would occlude ligand access to the heme iron, so the ternary complex can no longer form.	Iron	136-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	3-7
29202474-4	2018	We found that MYC upregulates ADHFE1 through changes in iron metabolism while coexpression of both ADHFE1 and MYC strongly enhanced orthotopic tumor growth in MCF7 cells.	Iron	56-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-17
29158088-3	2018	In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.	Iron	79-83	leptin receptor	Mus musculus	35-50
29158088-3	2018	In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.	Iron	79-83	leptin receptor	Mus musculus	235-261
29158088-3	2018	In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.	Iron	165-169	leptin receptor	Mus musculus	35-50
30959500-5	2018	In our interpretation, these findings are not in contrast, but they can be explained by a better understanding of the interactions between HD and ESAs on iron mobilization, first of all through the role of hepcidin.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	206-214
29035909-5	2018	Hepcidin-mediated iron-restricted anemia of critical illness requires further investigation of novel approaches involving erythropoiesis-stimulating agents, iron administration, and hepcidin modulation.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
29035909-5	2018	Hepcidin-mediated iron-restricted anemia of critical illness requires further investigation of novel approaches involving erythropoiesis-stimulating agents, iron administration, and hepcidin modulation.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	0-8
29183916-2	2018	Ceruloplasmin plays a role in iron homeostasis, and its activity impairment leads to iron accumulation in liver, pancreas, and brain.	Iron	30-34	ceruloplasmin	Mus musculus	0-13
29183916-2	2018	Ceruloplasmin plays a role in iron homeostasis, and its activity impairment leads to iron accumulation in liver, pancreas, and brain.	Iron	85-89	ceruloplasmin	Mus musculus	0-13
29183916-7	2018	Ceruloplasmin-treated mice showed amelioration of motor incoordination that was associated with diminished loss of Purkinje neurons and reduced brain iron deposition, in particular in the choroid plexus.	Iron	150-154	ceruloplasmin	Mus musculus	0-13
29134618-5	2018	Mutations of SLC40A1 that encodes ferroportin, the only cellular iron exporter, causes either HH type 4A (loss-of-function mutations) or HH type 4B (gain-of-function mutations).	Iron	65-69	solute carrier family 40 member 1	Homo sapiens	13-20
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	82-86	hemojuvelin BMP co-receptor	Homo sapiens	104-115
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	82-86	transferrin receptor 2	Homo sapiens	121-125
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	171-179
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	196-204
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	142-146	hemojuvelin BMP co-receptor	Homo sapiens	104-115
29134618-6	2018	Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells.	Iron	142-146	transferrin receptor 2	Homo sapiens	121-125
29196967-6	2018	The pharmacokinetic of oral and parenteral iron is substantially different, and diversities have become even clearer in light of the hepcidin master role in regulating systemic iron homeostasis.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	133-141
29376857-7	2018	Iron converts native alpha-SYN into a beta-sheet conformation and promotes its aggregation either directly or via increasing levels of oxidative stress.	Iron	0-4	synuclein alpha	Homo sapiens	21-30
29376857-8	2018	Interestingly, alpha-SYN possesses ferrireductase activity and alpha-SYN expression underlies iron mediated translational control via RNA stem loop structures.	Iron	94-98	synuclein alpha	Homo sapiens	15-24
29376857-8	2018	Interestingly, alpha-SYN possesses ferrireductase activity and alpha-SYN expression underlies iron mediated translational control via RNA stem loop structures.	Iron	94-98	synuclein alpha	Homo sapiens	63-72
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	Iron	27-31	endothelial PAS domain protein 1	Mus musculus	62-72
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	Iron	94-98	endothelial PAS domain protein 1	Mus musculus	62-72
29746244-0	2018	Approaches to Interrogate the Role of Nucleotide Hydrolysis by Metal Trafficking NTPases: The Nbp35-Cfd1 Iron-Sulfur Cluster Scaffold as a Case Study.	Iron	105-109	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	94-99
29746244-0	2018	Approaches to Interrogate the Role of Nucleotide Hydrolysis by Metal Trafficking NTPases: The Nbp35-Cfd1 Iron-Sulfur Cluster Scaffold as a Case Study.	Iron	105-109	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	100-104
29115497-2	2018	In the present study, its role in iron metabolism and the associated signaling pathways involved was investigated in a mouse model with insulin receptor substrate 1-loss of function (IRS-/-), and osteoblasts in the iron overload condition.	Iron	34-38	insulin receptor substrate 1	Mus musculus	136-164
29115497-7	2018	Collectively, the results of the present study indicated that hepcidin is involved in iron metabolism in IRS-1-/- mice via the signaling pathways involving BMP6 and IL-6.	Iron	86-90	insulin receptor substrate 1	Mus musculus	105-110
31406150-2	2019	Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in both MS patients and in the experimental autoimmune encephalomyelitis (EAE) model of MS. Divalent Metal Transporter1, a major iron importer in cells, is stimulated by signaling of Dexras1, a small G protein member of the Ras family.	Iron	258-262	ras related dexamethasone induced 1	Homo sapiens	312-319
31406150-6	2019	These results suggest that iron entry triggered by NO-activated Dexras1 signaling is a potential mechanism of neuronal death in experimental optic neuritis.	Iron	27-31	ras related dexamethasone induced 1	Homo sapiens	64-71
31066932-2	2019	Upon coordinating P4 to electron poor cyclopentadienyl-iron cations, the average P-P bond distances shrink and the respective P4 breathing mode in the Raman spectra (600 cm-1 , P4, free ) is blueshifted by &gt;40 cm-1 in [CpFe(CO)(L)(eta1 -P4 )]+ cations (L=CO or PPh3 ).	Iron	55-59	protein phosphatase 4 catalytic subunit	Homo sapiens	264-268
31395877-2	2019	Fe-S clusters are biosynthesized on the scaffold protein ISCU, with cysteine desulfurase NFS1 providing sulfur as persulfide and ferredoxin FDX2 supplying electrons, in a process stimulated by FXN but not clearly understood.	Iron	0-4	ferredoxin 2	Homo sapiens	140-144
31395877-4	2019	By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters.	Iron	27-31	ferredoxin 2	Homo sapiens	115-119
31447651-1	2019	An imbalance of iron metabolism with consecutive aggregation of alpha-synuclein and axonal degeneration of neurons has been postulated as the main pathological feature in the development of Parkinson"s disease (PD).	Iron	16-20	synuclein alpha	Homo sapiens	64-79
30890358-6	2019	The current knowledge suggests that asialo-hTf may be involved in regulation of iron transport and release at the hepatic level, which, consequently, could strongly be affected by alcohol consumption.	Iron	80-84	coagulation factor III, tissue factor	Homo sapiens	43-46
31267164-2	2019	In Hb M iron is present in the oxidized ferric state (Fe3+) not in the reduced ferrous form (Fe2+) and this reduces the ability of hemoglobin to bind oxygen.	Iron	8-12	hemoglobin subunit mu	Homo sapiens	3-7
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	Iron	28-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	9-12
31153641-0	2019	Increased hepcidin in hemorrhagic plaques correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	10-18
31153641-2	2019	Hepcidin increases iron retention and exerts proinflammatory effects in plaques.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	0-8
31153641-11	2019	In conclusion, our data indicate that hepcidin levels are increased in hemorrhagic plaques, which correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	38-46
31336775-11	2019	These results indicated that a combination of oral lactoferrin and iron injection is a more effective method of improving the iron level by up-regulating the expression of the LFR gene, enhancing the antioxidant ability and modulating the cytokine activity in the suckling piglets.	Iron	67-71	intelectin 1	Homo sapiens	176-179
31336775-11	2019	These results indicated that a combination of oral lactoferrin and iron injection is a more effective method of improving the iron level by up-regulating the expression of the LFR gene, enhancing the antioxidant ability and modulating the cytokine activity in the suckling piglets.	Iron	126-130	intelectin 1	Homo sapiens	176-179
30952001-1	2019	In this study, g-C3N4/PDI/Fe (gCPF) composite material was prepared by incorporating Fe ion on the composite catalyst of g-C3N4/PDI (gCP).	Iron	26-28	opsin 1, medium wave sensitive	Homo sapiens	30-33
30952001-2	2019	X-ray photoelectron spectroscopy (XPS) showed that the Fe was successfully incorporated on the pristine g-C3N4/PDI.	Iron	55-57	opsin 1, medium wave sensitive	Homo sapiens	104-114
31012886-1	2019	A cyclophane ligand (H6L) bearing three beta-oxo-delta-diimine arms and the corresponding tri-iron and -zinc complexes in which the metal ions are bridged by either chlorides, viz.	Iron	94-98	H6 family homeobox 2	Homo sapiens	21-24
29982259-4	2018	Hepcidin, through its ability to sequester iron within macrophages and induce H-ferritin, serves as an endogenous protective molecule against ferroptosis.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
31477260-4	2019	Hepcidin, a 25 amino acid peptide produced by the hepatocytes, has emerged as the key regulator of uptake and release of iron in the tissues to maintain a steady supply of iron to erythron and other tissues while avoiding higher levels of iron that could be detrimental to the organs.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	0-8
31055680-5	2019	Specifically, exercise-induced increases in the master iron regulatory hormone, hepcidin, has been highlighted as a contributing factor towards altered iron metabolism in athletes.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	80-88
30305507-4	2018	Hepcidin is the key regulator of systemic iron homeostasis, and suppression of hepcidin expression leads to an increase in iron absorption from the intestines, exacerbating systemic iron overload.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
30305507-4	2018	Hepcidin is the key regulator of systemic iron homeostasis, and suppression of hepcidin expression leads to an increase in iron absorption from the intestines, exacerbating systemic iron overload.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	79-87
30305507-4	2018	Hepcidin is the key regulator of systemic iron homeostasis, and suppression of hepcidin expression leads to an increase in iron absorption from the intestines, exacerbating systemic iron overload.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	79-87
31055680-5	2019	Specifically, exercise-induced increases in the master iron regulatory hormone, hepcidin, has been highlighted as a contributing factor towards altered iron metabolism in athletes.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	80-88
31082742-11	2019	CONCLUSION: Serum AMH level and AFC were significantly lower in women with transfusion dependent BTM as compared to age-matched healthy controls suggesting a direct impact of the disease activity or iron overload on the ovary.	Iron	199-203	anti-Mullerian hormone	Homo sapiens	18-21
30387158-8	2019	Icariin could protect against iron overload-induced mitochondrial membrane potential dysfunction and ROS production, promote osteoblast survival and reverse the reduction of Runx2, alkaline phosphatase, and osteopontin expression induced by iron overload.	Iron	30-34	secreted phosphoprotein 1	Homo sapiens	207-218
30387158-8	2019	Icariin could protect against iron overload-induced mitochondrial membrane potential dysfunction and ROS production, promote osteoblast survival and reverse the reduction of Runx2, alkaline phosphatase, and osteopontin expression induced by iron overload.	Iron	241-245	secreted phosphoprotein 1	Homo sapiens	207-218
31054940-8	2019	Although we formerly reported that SESN2 expression was reduced after p53 mutation in colon tumors, mouse colon tumors, which have intact p53 and NRF2, induced SESN2 expression in response to iron stimulus.	Iron	192-196	transformation related protein 53, pseudogene	Mus musculus	70-73
31054940-8	2019	Although we formerly reported that SESN2 expression was reduced after p53 mutation in colon tumors, mouse colon tumors, which have intact p53 and NRF2, induced SESN2 expression in response to iron stimulus.	Iron	192-196	transformation related protein 53, pseudogene	Mus musculus	138-141
31117349-1	2019	MitoNEET is a CDGSH iron-sulfur protein that has been a target for drug development for diseases such as type-2 diabetes, cancer, and Parkinson"s disease.	Iron	20-24	CDGSH iron sulfur domain 1	Homo sapiens	0-8
31117349-2	2019	Functions proposed for mitoNEET are as a redox sensor and regulator of free iron in the mitochondria.	Iron	76-80	CDGSH iron sulfur domain 1	Homo sapiens	23-31
31015783-1	2019	Introduction: Reliable determination of hepcidin-25, a key regulator of iron metabolism, is important.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	40-48
30861440-1	2019	The bacterial (dissimilatory) iron and sulfate reduction (BIR and BSR) are intimately linked to the biogeochemical cycling of C, Fe, and S in acid mine drainage (AMD) environments.	Iron	30-34	maternally expressed 8, small nucleolar RNA host gene	Homo sapiens	66-69
30861440-1	2019	The bacterial (dissimilatory) iron and sulfate reduction (BIR and BSR) are intimately linked to the biogeochemical cycling of C, Fe, and S in acid mine drainage (AMD) environments.	Iron	129-131	maternally expressed 8, small nucleolar RNA host gene	Homo sapiens	66-69
30975898-5	2019	Here, we developed iron-sulfur cluster synthesis and transfer functional assays and determined that the human ISCU2 M140I variant can substitute for FXN in accelerating the rate of iron-sulfur cluster formation on the monothiol glutaredoxin (GRX5) acceptor protein.	Iron	181-185	glutaredoxin 5	Homo sapiens	242-246
30975898-7	2019	In contrast to the canonical role of FXN in stimulating the formation of [2Fe-2S]-ISCU2 intermediates, we found here that the M140I substitution in ISCU2 promotes the transfer of iron-sulfur clusters to GRX5.	Iron	179-183	glutaredoxin 5	Homo sapiens	203-207
31231185-2	2019	The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI).	Iron	121-125	solute carrier family 11 member 2	Homo sapiens	168-196
31231185-2	2019	The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI).	Iron	121-125	solute carrier family 11 member 2	Homo sapiens	198-202
31231185-2	2019	The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI).	Iron	243-247	solute carrier family 11 member 2	Homo sapiens	168-196
31231185-2	2019	The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI).	Iron	243-247	solute carrier family 11 member 2	Homo sapiens	198-202
31231185-4	2019	This review highlights the contribution of DMT1 to the physiological exchange and distribution of body iron and heavy metals during aging and neurodegenerative diseases.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	43-47
31231185-5	2019	DMT1 also mediates the crosstalk between central nervous system and peripheral tissues, by systemic diffusion through the Blood Brain Barrier (BBB), with the involvement of peripheral iron homeostasis in association with inflammation.	Iron	184-188	solute carrier family 11 member 2	Homo sapiens	0-4
30901137-1	2019	Aceruloplasminemia is a rare form of brain iron overload of autosomal recessive inheritance that results from mutations in the CP gene, encoding the iron oxidase ceruloplasmin.	Iron	43-47	ceruloplasmin	Homo sapiens	127-129
30901137-1	2019	Aceruloplasminemia is a rare form of brain iron overload of autosomal recessive inheritance that results from mutations in the CP gene, encoding the iron oxidase ceruloplasmin.	Iron	43-47	ceruloplasmin	Homo sapiens	1-14
30901137-1	2019	Aceruloplasminemia is a rare form of brain iron overload of autosomal recessive inheritance that results from mutations in the CP gene, encoding the iron oxidase ceruloplasmin.	Iron	149-153	ceruloplasmin	Homo sapiens	127-129
30901137-1	2019	Aceruloplasminemia is a rare form of brain iron overload of autosomal recessive inheritance that results from mutations in the CP gene, encoding the iron oxidase ceruloplasmin.	Iron	149-153	ceruloplasmin	Homo sapiens	1-14
30500107-5	2019	To analyse iron export capacity of the SLC40A1 p.Y333H mutant, the 293T cells were transfected with the SLC40A1 p.Y333H construct and then treated with hepcidin after exposure to ferric ammonium citrate.	Iron	11-15	solute carrier family 40 member 1	Homo sapiens	39-46
30500107-7	2019	RESULTS: Of 22 unrelated cases with primary iron overload, three cases (3/22, 13.6%) harboured the SLC40A1 p.Y333H, with no missense mutations identified in any other classical haemochromatosis-related genes including HFE, HJV, HAMP and TFR2.	Iron	44-48	solute carrier family 40 member 1	Homo sapiens	99-108
31213851-0	2019	Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway.	Iron	63-67	doublesex and mab-3 related transcription factor 1	Homo sapiens	49-53
31213851-7	2019	Results: In this study, we found that DFO treatment significantly increased the levels of iron uptake proteins, DMT1 and TfR1, in aggressive TNBCs.	Iron	90-94	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
31213851-8	2019	Moreover, both TfR1 and DMT1 expressed on cell membrane were involved in high iron uptake in TNBCs under DFO-induced iron deficient condition.	Iron	78-82	doublesex and mab-3 related transcription factor 1	Homo sapiens	24-28
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	132-136	doublesex and mab-3 related transcription factor 1	Homo sapiens	105-109
31156682-7	2019	In the clf mutant, which lacks the predominant H3K27 tri-methyltransferase, induction of FIT, FRO2, IRT1, and other FIT-regulated genes in roots is significantly higher under iron deficient conditions than in wild type.	Iron	175-179	allograft inflammatory factor 1	Homo sapiens	100-104
31040213-3	2019	The increase of Hif1alpha up-regulated its targeted genes, enhancing glycolysis, and the increase of Hif2alpha down-regulated the expression of iron-sulfur cluster (Fe-S) biogenesis-related and electron transport chain (ETC)-related genes, weakening mitochondrial respiration.	Iron	165-169	hypoxia inducible factor 1, alpha subunit	Mus musculus	16-25
31040213-3	2019	The increase of Hif1alpha up-regulated its targeted genes, enhancing glycolysis, and the increase of Hif2alpha down-regulated the expression of iron-sulfur cluster (Fe-S) biogenesis-related and electron transport chain (ETC)-related genes, weakening mitochondrial respiration.	Iron	165-169	endothelial PAS domain protein 1	Mus musculus	101-110
31040213-5	2019	Inhibition of Hif2alpha by genetic knockdown or selective disruption of the heterodimerization of Hif2alpha and Hif1beta restored the mitochondrial ETC and coupled oxidative phosphorylation (OXPHOS) by enhancing Fe-S biogenesis and increasing ETC-related gene expression.	Iron	212-216	endothelial PAS domain protein 1	Mus musculus	14-23
31040213-5	2019	Inhibition of Hif2alpha by genetic knockdown or selective disruption of the heterodimerization of Hif2alpha and Hif1beta restored the mitochondrial ETC and coupled oxidative phosphorylation (OXPHOS) by enhancing Fe-S biogenesis and increasing ETC-related gene expression.	Iron	212-216	endothelial PAS domain protein 1	Mus musculus	98-107
31040213-5	2019	Inhibition of Hif2alpha by genetic knockdown or selective disruption of the heterodimerization of Hif2alpha and Hif1beta restored the mitochondrial ETC and coupled oxidative phosphorylation (OXPHOS) by enhancing Fe-S biogenesis and increasing ETC-related gene expression.	Iron	212-216	hypoxia inducible factor 1, alpha subunit	Mus musculus	112-120
30987423-4	2019	After sandwiching the target PSA between Ab1 and Ab2, the MNP/Ab1-PSA-Ab2/L@MIL-53(Fe) were introduced to a gold anodic BPE.	Iron	83-85	kallikrein related peptidase 3	Homo sapiens	66-69
30995014-2	2019	Two nuCN bands at 1604 and 1548 cm-1 indicated bidentate coordination of ToM to iron in 2.	Iron	80-84	pre-mRNA processing factor 6	Homo sapiens	73-76
30995014-6	2019	A single 1H NMR signal assigned to the methyl groups of the ToM ligand suggested tridentate coordination of the ToM ligand to iron in 1 and 3.	Iron	126-130	pre-mRNA processing factor 6	Homo sapiens	60-63
30995014-6	2019	A single 1H NMR signal assigned to the methyl groups of the ToM ligand suggested tridentate coordination of the ToM ligand to iron in 1 and 3.	Iron	126-130	pre-mRNA processing factor 6	Homo sapiens	112-115
30677788-2	2019	Hepcidin production, controlled by bone morphogenic protein 6 (BMP6), regulates iron homeostasis via interactions with the iron transporter, ferroportin.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
30677788-3	2019	High hepcidin levels are thought to contribute to increased iron sequestration and subsequent anaemia in CKD patients.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	5-13
29562821-6	2018	At 48 hours, there was an increase in intracellular labile iron, which was associated with a significant reduction in hepcidin and ferritin expression and a significant increase in ferroportin expression.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	118-126
30828802-0	2019	Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	57-65
31115230-12	2019	After consultation with a hematologist, serum hepcidin concentration (an iron homeostasis regulator) was quantified: 19.4 microg/L.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	46-54
29132816-0	2018	Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis.	Iron	21-25	coagulation factor III, tissue factor	Homo sapiens	43-56
31115230-15	2019	During infection, inflammatory cytokines increase hepcidin secretion, leading to iron deposition into cells.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	50-58
28756878-1	2017	Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted into bilirubin.	Iron	116-120	heme oxygenase 1	Homo sapiens	0-16
30855332-2	2019	RECENT FINDINGS: The importance of the hepcidin/ferroportin axis in the modulation of intestinal HIF-2 to regulate iron absorption has been recently highlighted.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	39-47
28756878-1	2017	Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted into bilirubin.	Iron	116-120	heme oxygenase 1	Homo sapiens	18-22
29247214-7	2017	Moreover, we found a trend toward poorer outcome in CCA patients with elevated expression of ferritin and hepcidin, two major proteins of iron metabolism.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	106-114
30855332-3	2019	Latest advances also reveal a direct titration of the bone morphogenetic proteins by the erythroferrone contributing to liver hepcidin suppression to increase iron availability.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	126-134
30855336-8	2019	Newer approaches to ameliorate iron toxicity have focused on the hepcidin pathway, all of which would result in increased hepcidin levels and reduction of iron absorption from the intestine, sequestration of iron in normal storage sites and reduced exposure of more susceptible organs, such as the heart and endocrine organs, to the toxic effects of increased iron.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	65-73
30855336-8	2019	Newer approaches to ameliorate iron toxicity have focused on the hepcidin pathway, all of which would result in increased hepcidin levels and reduction of iron absorption from the intestine, sequestration of iron in normal storage sites and reduced exposure of more susceptible organs, such as the heart and endocrine organs, to the toxic effects of increased iron.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	122-130
28919067-3	2017	Hepcidin, the key iron metabolism hormone, may be a good marker of ID in these patients.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
30855336-8	2019	Newer approaches to ameliorate iron toxicity have focused on the hepcidin pathway, all of which would result in increased hepcidin levels and reduction of iron absorption from the intestine, sequestration of iron in normal storage sites and reduced exposure of more susceptible organs, such as the heart and endocrine organs, to the toxic effects of increased iron.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	65-73
30855336-8	2019	Newer approaches to ameliorate iron toxicity have focused on the hepcidin pathway, all of which would result in increased hepcidin levels and reduction of iron absorption from the intestine, sequestration of iron in normal storage sites and reduced exposure of more susceptible organs, such as the heart and endocrine organs, to the toxic effects of increased iron.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	65-73
30855336-8	2019	Newer approaches to ameliorate iron toxicity have focused on the hepcidin pathway, all of which would result in increased hepcidin levels and reduction of iron absorption from the intestine, sequestration of iron in normal storage sites and reduced exposure of more susceptible organs, such as the heart and endocrine organs, to the toxic effects of increased iron.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	65-73
29907846-11	2019	At the same time, higher hepcidin concentrations may lower serum iron mass.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	25-33
29328038-0	2017	QUANTITATIVE ASSESSMENT OF THE RESULTS OF VIMENTIN IMMUNOHISTOCHEMICAL EXAMINATION IN FIBROBLASTS AND ENDOTHELIOCYTES OF THE PLACENTAL VILLI IN THE ASPECT OF PRETERM MATURATION OF THE CHORIONIC TREE AND IRON DEFICIENCY ANEMIA OF GRAVIDAS.	Iron	203-207	vimentin	Homo sapiens	42-50
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	C-C motif chemokine ligand 2	Homo sapiens	101-105
28945637-3	2017	We aimed to assess serum hepcidin concentration in IBD children and correlate hepcidin with iron status parameters and inflammatory markers.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	78-86
28945637-15	2017	It may suggest that in our cohort, hepcidin was regulated predominantly by iron storage level.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	35-43
30835899-7	2019	Iron loading of macrophages with IL-4 also resulted in reduced phosphorylation of STAT6, another transcriptional regulator of M2 activation.	Iron	0-4	signal transducer and activator of transcription 6	Homo sapiens	82-87
31104454-10	2019	CONCLUSION: Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.	Iron	40-44	ret proto-oncogene	Homo sapiens	108-111
29075067-1	2017	In this study, the potential effect of three HFE gene polymorphisms (C282Y, H63D and S65C) and the SLC40A1 A77D polymorphism on iron balance was investigated in 234 subjects (91 Arab beta-thalassemia major (BTM) patients, 34 beta-thalassemia trait (BTT) individuals and 109 health controls).	Iron	128-132	solute carrier family 40 member 1	Homo sapiens	99-106
29098522-0	2017	Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major: Correspondence.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	6-14
28811225-3	2017	Recently, it has been suggested that alpha-synuclein could cause the enzymatic reduction of iron and a cellular increase in Fe(II) levels.	Iron	92-96	synuclein alpha	Homo sapiens	37-52
28079060-1	2017	Growing evidence suggests that lactoferrin (Lf), an iron-binding glycoprotein, is a pleiotropic functional nutrient.	Iron	52-56	lactotransferrin	Mus musculus	31-42
28079060-1	2017	Growing evidence suggests that lactoferrin (Lf), an iron-binding glycoprotein, is a pleiotropic functional nutrient.	Iron	52-56	HLF transcription factor, PAR bZIP family member	Homo sapiens	44-46
29021231-4	2017	Loss of Bmp6 further repressed Smad signaling and hepcidin expression in the liver of Hjv-/- mice of both sexes, and led to iron accumulation in the pancreas and the heart of females.	Iron	124-128	bone morphogenetic protein 6	Mus musculus	8-12
29021231-5	2017	These data suggest that, in Hjv-/- females, Bmp6 can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading.	Iron	144-148	bone morphogenetic protein 6	Mus musculus	44-48
28864813-1	2017	The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12.	Iron	39-43	FK506 binding protein 1a	Mus musculus	210-229
29123211-4	2017	Specifically, enhancing a cement paste with iron-based magnetic particles improves the bandwidth and S11 of embedded antennas.	Iron	44-48	surface antigen (X-linked) 2	Homo sapiens	101-104
29151689-10	2017	While earliest morphological signs of inflammation in liver were visible after 6 h, increased expression of the two acute-phase cytokines IFN-gamma (1h) and IL-1beta (3h) was detectable earlier, with maximum values after 12-24 h. Iron concentrations in liver tissue increased steadily between 1 h and 48 h, and remained high at 96 h. In contrast, spleen iron concentrations remained unchanged until 48 h, and increased mildly thereafter (96 h).	Iron	230-234	interferon gamma	Rattus norvegicus	138-147
29151689-10	2017	While earliest morphological signs of inflammation in liver were visible after 6 h, increased expression of the two acute-phase cytokines IFN-gamma (1h) and IL-1beta (3h) was detectable earlier, with maximum values after 12-24 h. Iron concentrations in liver tissue increased steadily between 1 h and 48 h, and remained high at 96 h. In contrast, spleen iron concentrations remained unchanged until 48 h, and increased mildly thereafter (96 h).	Iron	354-358	interferon gamma	Rattus norvegicus	138-147
28887319-4	2017	The activation of the ASK1-p38 pathway is mediated by critical determinants of ferroptosis: MEK activity, iron ions, and lipid peroxide.	Iron	106-110	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	22-26
28906593-0	2017	Analysis of NFU-1 metallocofactor binding-site substitutions-impacts on iron-sulfur cluster coordination and protein structure and function.	Iron	72-76	NFU1 iron-sulfur cluster scaffold	Homo sapiens	12-17
29204234-2	2017	They showed early carotid atherosclerosis as showed by increased carotid intima media thickness (CIMT) that may occur early even when significant iron overload is absent.	Iron	146-150	CIMT	Homo sapiens	97-101
29036620-6	2017	Expression analysis using FE-inducible systems and chromatin immunoprecipitation assays showed that FE directly bound to the FT and NaKR1 promoters and activated the transcription of downstream target genes.	Iron	100-102	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	125-127
29093559-1	2017	Hepcidin is a small cysteine rich peptide that regulates the sole known cellular iron exporter, ferroportin, effectively controlling iron metabolism.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
29093559-1	2017	Hepcidin is a small cysteine rich peptide that regulates the sole known cellular iron exporter, ferroportin, effectively controlling iron metabolism.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	0-8
29163402-3	2017	Once induced, HO-1 degrades iron-containing heme into ferrous iron (Fe2+), carbon monoxide (CO) and biliverdin.	Iron	28-32	heme oxygenase 1	Homo sapiens	14-18
29163402-3	2017	Once induced, HO-1 degrades iron-containing heme into ferrous iron (Fe2+), carbon monoxide (CO) and biliverdin.	Iron	54-66	heme oxygenase 1	Homo sapiens	14-18
28890316-6	2017	We also show that iron biomineral deposits in the cortical tissue contain the mineral magnetite, and provide evidence that Abeta-induced chemical reduction of iron could occur in vivo.	Iron	18-22	amyloid beta (A4) precursor protein	Mus musculus	123-128
28890316-6	2017	We also show that iron biomineral deposits in the cortical tissue contain the mineral magnetite, and provide evidence that Abeta-induced chemical reduction of iron could occur in vivo.	Iron	159-163	amyloid beta (A4) precursor protein	Mus musculus	123-128
28834022-0	2017	Protonation of Ferrocene: A Low-Temperature X-ray Diffraction Study of [Cp2 FeH](PF6 ) Reveals an Iron-Bound Hydrido Ligand.	Iron	98-102	ceruloplasmin	Homo sapiens	72-75
28834022-1	2017	Ferrocene, Cp2 Fe, is quantitatively protonated in a mixture of liquid HF/PF5 to yield [Cp2 FeH](PF6 ), which was characterized by 1 H/13 C NMR and 57 Fe Mossbauer spectroscopy as well as single-crystal X-ray diffraction analysis.	Iron	0-2	ceruloplasmin	Homo sapiens	11-14
28834022-1	2017	Ferrocene, Cp2 Fe, is quantitatively protonated in a mixture of liquid HF/PF5 to yield [Cp2 FeH](PF6 ), which was characterized by 1 H/13 C NMR and 57 Fe Mossbauer spectroscopy as well as single-crystal X-ray diffraction analysis.	Iron	0-2	ceruloplasmin	Homo sapiens	88-91
29018170-7	2017	To test whether transient TRPV channel permeability in neural crest cells was sufficient to induce these defects, we engineered iron-binding modifications to TRPV1 and TRPV4 that enabled remote and noninvasive activation of these channels in specific cellular locations and at specific developmental times in chick embryos with radio-frequency electromagnetic fields.	Iron	128-132	transient receptor potential cation channel subfamily V member 1	Gallus gallus	158-163
28681497-1	2017	The hepcidin-ferroportin axis underlies the pathophysiology of many iron-associated disorders and is a key target for the development of therapeutics for treating iron-associated disorders.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	4-12
28681497-1	2017	The hepcidin-ferroportin axis underlies the pathophysiology of many iron-associated disorders and is a key target for the development of therapeutics for treating iron-associated disorders.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	4-12
28605609-2	2017	Exercise-induced inflammation impedes iron absorption in the digestive tract by upregulating the expression of the iron regulatory protein, hepcidin.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	140-148
28605609-2	2017	Exercise-induced inflammation impedes iron absorption in the digestive tract by upregulating the expression of the iron regulatory protein, hepcidin.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	140-148
28697999-0	2017	The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis.	Iron	41-45	tet methylcytosine dioxygenase 2	Mus musculus	23-27
28697999-9	2017	These direct and indirect pathways of TET2 synergistically cooperated to mediating iron metabolism during stress erythropoiesis.	Iron	83-87	tet methylcytosine dioxygenase 2	Mus musculus	38-42
28697999-10	2017	Our work revealed a critical role of TET2-mediated DNA demethylation against oxidative stress, and provided the molecular mechanisms underlying the epigenetic regulation of iron homeostasis in response to stress erythropoiesis.	Iron	173-177	tet methylcytosine dioxygenase 2	Mus musculus	37-41
28840425-7	2017	However, in the recombinant cells that showed higher intracellular iron levels than wild-type cells, HFE and HAMP expressions were elevated only at low 1 g/L treatment (p &lt; 0.03) and were repressed at 2 g/L treatment (p &lt; 0.03).	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	109-113
28840425-8	2017	Under holotransferrin-untreated conditions, the iron-loaded recombinant cells showed higher expressions of HFE (p &lt; 0.03) and HAMP (p = 0.05) than wild-type cells.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	129-133
28840425-11	2017	Repression of HAMP expression under simultaneous intracellular and extracellular iron-loading resembles non-hereditary iron-excess pathologies.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	14-18
28840425-11	2017	Repression of HAMP expression under simultaneous intracellular and extracellular iron-loading resembles non-hereditary iron-excess pathologies.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	14-18
28937680-4	2017	Here, we provide evidence that a synthetic derivative of salinomycin, which we named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, by accumulating and sequestering iron in lysosomes.	Iron	85-89	adrenomedullin 5 (putative)	Homo sapiens	97-100
28385457-10	2017	Conversely, hepcidin reflected iron metabolism cross-sectionally, but changes in acute phase response longitudinally.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	12-20
28656646-6	2017	Compared to fresh RBC transfusion, plasma iron measured by non-transferrin-bound iron levels increased with iron sucrose at 7, 10, 13, 16, 24, and 48 hours (p = 0.04 to p &lt; 0.0001) and ferumoxytol at 7, 24, and 48 hours (p = 0.04 to p = 0.004).	Iron	42-46	inhibitor of carbonic anhydrase	Canis lupus familiaris	63-74
28901363-4	2017	(PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin).	Iron	5-7	peptidyl arginine deiminase 1	Homo sapiens	1-4
28901363-4	2017	(PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin).	Iron	5-7	peptidyl arginine deiminase 1	Homo sapiens	73-76
28901363-4	2017	(PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin).	Iron	5-7	peptidyl arginine deiminase 1	Homo sapiens	73-76
28901363-4	2017	(PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin).	Iron	77-79	peptidyl arginine deiminase 1	Homo sapiens	1-4
28901363-4	2017	(PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin).	Iron	77-79	peptidyl arginine deiminase 1	Homo sapiens	73-76
28901363-4	2017	(PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin).	Iron	77-79	peptidyl arginine deiminase 1	Homo sapiens	73-76
28901363-6	2017	This system has an unusual anti-ferromagnetic coupling between high spin electrons on the Fe center and the unpaired spin in the pi system of the non-innocent redox-active PDI ligand.	Iron	90-92	peptidyl arginine deiminase 1	Homo sapiens	172-175
28929355-3	2017	In this paper, a facile post-treatment method was applied to consume the excess iron, which was oxidized to Fe3O4 after post-treatment at 150 and 200  C, and a monodisperse binary FePt-Fe3O4 nanoparticle system was generated.	Iron	80-84	solute carrier family 35 member G1	Homo sapiens	24-28
28929355-3	2017	In this paper, a facile post-treatment method was applied to consume the excess iron, which was oxidized to Fe3O4 after post-treatment at 150 and 200  C, and a monodisperse binary FePt-Fe3O4 nanoparticle system was generated.	Iron	80-84	solute carrier family 35 member G1	Homo sapiens	120-124
28760824-0	2017	The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast.	Iron	107-111	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	54-58
28760824-3	2017	Transcription of the CCC1 gene is largely regulated by the binding of iron-sulfur clusters to the activator domain of the transcriptional activator Yap5.	Iron	70-74	Yap5p	Saccharomyces cerevisiae S288C	148-152
28760824-4	2017	Additional evidence, however, suggests that Yap5-independent transcriptional activation of CCC1 also contributes to iron resistance.	Iron	116-120	Yap5p	Saccharomyces cerevisiae S288C	44-48
28760824-6	2017	We found that SNF1 deletion acts synergistically with YAP5 deletion to regulate CCC1 transcription and iron resistance.	Iron	103-107	Yap5p	Saccharomyces cerevisiae S288C	54-58
28527388-6	2017	XPS spectra indicated that both Fe(II) and S(-II) on the S-nZVI surface were oxidized during the reaction, suggesting that FeS might act as both catalyst and reactant.	Iron	123-126	transcription elongation factor A1	Homo sapiens	43-48
28895913-2	2017	The aim of this study was to examine the iron bioavailability of a novel home fortificant, the "Lucky Iron Fish " (LIF) (www.luckyironfish.com/shop, Guelph, Canada) and the impact of dietary factors and a food matrix on iron uptake from LIF in Caco-2 cells.	Iron	102-106	LIF interleukin 6 family cytokine	Homo sapiens	115-118
28895913-3	2017	LIF released a substantial quantity of iron (about 1.2 mM) at pH 2 but this iron was only slightly soluble at pH 7 and not taken up by cells.	Iron	39-43	LIF interleukin 6 family cytokine	Homo sapiens	0-3
28895913-3	2017	LIF released a substantial quantity of iron (about 1.2 mM) at pH 2 but this iron was only slightly soluble at pH 7 and not taken up by cells.	Iron	76-80	LIF interleukin 6 family cytokine	Homo sapiens	0-3
28895913-4	2017	The addition of ascorbic acid (AA) maintained the solubility of iron released from LIF (LIF-iron) at pH 7 and facilitated iron uptake by the cells in a concentration-dependent manner.	Iron	64-68	LIF interleukin 6 family cytokine	Homo sapiens	83-86
28895913-4	2017	The addition of ascorbic acid (AA) maintained the solubility of iron released from LIF (LIF-iron) at pH 7 and facilitated iron uptake by the cells in a concentration-dependent manner.	Iron	64-68	LIF interleukin 6 family cytokine	Homo sapiens	88-91
28895913-4	2017	The addition of ascorbic acid (AA) maintained the solubility of iron released from LIF (LIF-iron) at pH 7 and facilitated iron uptake by the cells in a concentration-dependent manner.	Iron	92-96	LIF interleukin 6 family cytokine	Homo sapiens	83-86
28895913-4	2017	The addition of ascorbic acid (AA) maintained the solubility of iron released from LIF (LIF-iron) at pH 7 and facilitated iron uptake by the cells in a concentration-dependent manner.	Iron	92-96	LIF interleukin 6 family cytokine	Homo sapiens	88-91
28895913-4	2017	The addition of ascorbic acid (AA) maintained the solubility of iron released from LIF (LIF-iron) at pH 7 and facilitated iron uptake by the cells in a concentration-dependent manner.	Iron	92-96	LIF interleukin 6 family cytokine	Homo sapiens	83-86
28895913-4	2017	The addition of ascorbic acid (AA) maintained the solubility of iron released from LIF (LIF-iron) at pH 7 and facilitated iron uptake by the cells in a concentration-dependent manner.	Iron	92-96	LIF interleukin 6 family cytokine	Homo sapiens	88-91
28895913-5	2017	In vitro digestion of LIF-iron in the presence of peas increased iron uptake 10-fold.	Iron	26-30	LIF interleukin 6 family cytokine	Homo sapiens	22-25
28895913-5	2017	In vitro digestion of LIF-iron in the presence of peas increased iron uptake 10-fold.	Iron	65-69	LIF interleukin 6 family cytokine	Homo sapiens	22-25
28895913-7	2017	Additionally, LIF-iron induced an overproduction of reactive oxygen species (ROS), similar to ferrous sulfate, but this effect was counteracted by the addition of AA.	Iron	18-22	LIF interleukin 6 family cytokine	Homo sapiens	14-17
28913435-9	2017	In addition, NFU1 protein expression was also decreased, which is required for the assembly of a subset of iron-sulfur proteins to SDH and LIAS in the mitochondrial ISC assembly system.	Iron	107-111	NFU1 iron-sulfur cluster scaffold	Homo sapiens	13-17
28913435-9	2017	In addition, NFU1 protein expression was also decreased, which is required for the assembly of a subset of iron-sulfur proteins to SDH and LIAS in the mitochondrial ISC assembly system.	Iron	107-111	lipoic acid synthetase	Homo sapiens	139-143
28494509-3	2017	Oral iron supplements also increase hepcidin production causing decreased fractional absorption of subsequent doses.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	36-44
28630009-1	2017	Frataxin is a ubiquitous protein that plays a role in Fe-S cluster biosynthesis and iron and heme metabolism, although its molecular functions are not entirely clear.	Iron	54-56	frataxin	Zea mays	0-8
28630009-1	2017	Frataxin is a ubiquitous protein that plays a role in Fe-S cluster biosynthesis and iron and heme metabolism, although its molecular functions are not entirely clear.	Iron	84-88	frataxin	Zea mays	0-8
29024968-0	2017	Iron suppresses ovarian granulosa cell proliferation and arrests cell cycle through regulating p38 mitogen-activated protein kinase/p53/p21 pathway.	Iron	0-4	transformation related protein 53, pseudogene	Mus musculus	132-135
28824243-9	2017	Hepcidin levels remain low during pregnancy as there is increased demand for iron in pregnancy.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
28824243-10	2017	Iron supplementation results in increased hepcidin levels; however no mathematical correlation was found between serum hepcidin level and serum iron profile.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	42-50
28543377-1	2017	Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
28543377-1	2017	Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	0-8
30656573-0	2019	Validated Nuclear-Based Transgene Expression Regulated by the Fea1 Iron-Responsive Promoter in the Green Alga Chlamydomonas reinhardtii.	Iron	67-71	uncharacterized protein	Chlamydomonas reinhardtii	62-66
28600471-7	2017	Additionally, wild-type Nx mice, but not DDAH-1 Tg Nx mice, had reduced splenic gene expression of erythropoietin receptor and erythroferrone, which regulates iron metabolism in response to erythropoietin.	Iron	159-163	erythropoietin	Mus musculus	99-113
28600471-7	2017	Additionally, wild-type Nx mice, but not DDAH-1 Tg Nx mice, had reduced splenic gene expression of erythropoietin receptor and erythroferrone, which regulates iron metabolism in response to erythropoietin.	Iron	159-163	erythropoietin	Mus musculus	190-204
30656573-6	2019	In this work, parameters of induction and deactivation of the iron-responsive Fea1 promoter were analyzed over time in C. reinhardtii.	Iron	62-66	uncharacterized protein	Chlamydomonas reinhardtii	78-82
30656573-10	2019	Activation of the Fea1 promoter occurred promptly and prominently when cells were transferred to iron-deplete medium.	Iron	97-101	uncharacterized protein	Chlamydomonas reinhardtii	18-22
30660753-5	2019	The molecular mechanism of cytochrome B mutation was that the mutant variant interferes with the site of heme binding (iron containing) domain and calcium binding essential for electron transport chain.	Iron	119-123	cytochrome b	Ovis aries	27-39
29135121-1	2017	PURPOSE: To investigate the relationship between Hepcidin and iron metabolism, and cell proliferation, migration, and apoptosis in prostate cancer cells.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	49-57
30797969-8	2019	Antioxidant NAC could fully block iron-induced upregulation of CK2, PLK2 and pS129 alpha-synuclein levels, indicating oxidative stress plays a critical role in iron-induced alpha-synuclein phosphorylation.	Iron	34-38	polo like kinase 2	Homo sapiens	68-72
29135121-11	2017	CONCLUSIONS: Hepcidin is highly expressed in prostate cancer cells, and can regulate cell proliferation, migration, and apoptosis by increasing intracellular iron transportation.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	13-21
28623611-0	2017	Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation.	Iron	56-60	synuclein, alpha	Mus musculus	90-105
30797969-8	2019	Antioxidant NAC could fully block iron-induced upregulation of CK2, PLK2 and pS129 alpha-synuclein levels, indicating oxidative stress plays a critical role in iron-induced alpha-synuclein phosphorylation.	Iron	34-38	synuclein alpha	Homo sapiens	83-98
30797969-8	2019	Antioxidant NAC could fully block iron-induced upregulation of CK2, PLK2 and pS129 alpha-synuclein levels, indicating oxidative stress plays a critical role in iron-induced alpha-synuclein phosphorylation.	Iron	34-38	synuclein alpha	Homo sapiens	173-188
30797969-8	2019	Antioxidant NAC could fully block iron-induced upregulation of CK2, PLK2 and pS129 alpha-synuclein levels, indicating oxidative stress plays a critical role in iron-induced alpha-synuclein phosphorylation.	Iron	160-164	synuclein alpha	Homo sapiens	12-15
28758386-7	2017	Correlation of these frequencies with their CT1 energies reveals strong H-bond donation to the F- ligand, indicating that atoms directly coordinated to heme iron are accessible to distal H-bond donation.	Iron	157-161	cardiotrophin 1	Homo sapiens	44-47
30797969-8	2019	Antioxidant NAC could fully block iron-induced upregulation of CK2, PLK2 and pS129 alpha-synuclein levels, indicating oxidative stress plays a critical role in iron-induced alpha-synuclein phosphorylation.	Iron	160-164	synuclein alpha	Homo sapiens	173-188
28842692-3	2017	Fe3O4-Fe nanohybrids-containing electrodes exhibited a high discharge capacity (13,890 mA h gc-1 at a current density of 500 mA gc-1), long cycle stability (100 cycles at a current rate of 500 mA gc-1 and fixed capacity regime of 1,000 mA h gc-1), and low overpotential (1.39 V at 40 cycles).	Iron	0-2	solute carrier family 25 member 22	Homo sapiens	92-96
30797969-9	2019	However, iron-induced alpha-synuclein up-regulation could only be partially blocked by CK2/PLK2 inhibitor or NAC.	Iron	9-13	synuclein alpha	Homo sapiens	22-37
28842692-3	2017	Fe3O4-Fe nanohybrids-containing electrodes exhibited a high discharge capacity (13,890 mA h gc-1 at a current density of 500 mA gc-1), long cycle stability (100 cycles at a current rate of 500 mA gc-1 and fixed capacity regime of 1,000 mA h gc-1), and low overpotential (1.39 V at 40 cycles).	Iron	0-2	solute carrier family 25 member 22	Homo sapiens	128-132
28842692-3	2017	Fe3O4-Fe nanohybrids-containing electrodes exhibited a high discharge capacity (13,890 mA h gc-1 at a current density of 500 mA gc-1), long cycle stability (100 cycles at a current rate of 500 mA gc-1 and fixed capacity regime of 1,000 mA h gc-1), and low overpotential (1.39 V at 40 cycles).	Iron	0-2	solute carrier family 25 member 22	Homo sapiens	128-132
30797969-9	2019	However, iron-induced alpha-synuclein up-regulation could only be partially blocked by CK2/PLK2 inhibitor or NAC.	Iron	9-13	polo like kinase 2	Homo sapiens	91-95
30797969-9	2019	However, iron-induced alpha-synuclein up-regulation could only be partially blocked by CK2/PLK2 inhibitor or NAC.	Iron	9-13	synuclein alpha	Homo sapiens	109-112
30797969-10	2019	These findings demonstrate that iron-induced oxidative stress is largely responsible for alpha-synuclein phosphorylation and upregulation via CK2 and PLK2, and alpha-synuclein upregulation is not fully phosphorylation-dependent.	Iron	32-36	synuclein alpha	Homo sapiens	89-104
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	35-39	solute carrier family 11 member 2	Homo sapiens	124-128
30797969-10	2019	These findings demonstrate that iron-induced oxidative stress is largely responsible for alpha-synuclein phosphorylation and upregulation via CK2 and PLK2, and alpha-synuclein upregulation is not fully phosphorylation-dependent.	Iron	32-36	polo like kinase 2	Homo sapiens	150-154
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	35-39	solute carrier family 40 member 1	Homo sapiens	168-181
31276102-3	2019	Here, we show that Nrf2 is activated by iron-induced, mitochondria-derived pro-oxidants and drives Bmp6 expression in liver sinusoid endothelial cells, which in turn increases hepcidin synthesis by neighbouring hepatocytes.	Iron	40-44	bone morphogenetic protein 6	Mus musculus	99-103
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	124-128
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	solute carrier family 40 member 1	Homo sapiens	168-181
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	124-128
28655775-3	2017	Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1.	Iron	114-118	solute carrier family 40 member 1	Homo sapiens	168-181
31276102-4	2019	In Nrf2 knockout mice, the Bmp6-hepcidin response to oral and parenteral iron is impaired and iron accumulation and hepatic damage are increased.	Iron	73-77	bone morphogenetic protein 6	Mus musculus	27-31
31276102-5	2019	Pharmacological activation of Nrf2 stimulates the Bmp6-hepcidin axis, improving iron homeostasis in haemochromatosis and counteracting the inhibition of Bmp6 by erythroferrone in beta-thalassaemia.	Iron	80-84	bone morphogenetic protein 6	Mus musculus	50-54
31054269-2	2019	The most common cause is hereditary haemochromatosis (HH), a genetic disorder triggered by inactivation of the iron hormone hepcidin, which results in hyperferraemia and excessive tissue iron deposition.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	124-132
28774348-2	2017	The heavy subunit (FHC) is provided of a ferroxidase activity and thus performs the key transformation of iron in a non-toxic form.	Iron	106-110	low density lipoprotein receptor	Homo sapiens	19-22
28774348-3	2017	Recently, it has been shown that FHC is also involved in additional not iron-related critical pathways including, among the others, p53 regulation, modulation of oncomiRNAs expression and chemokine signalling.	Iron	72-76	low density lipoprotein receptor	Homo sapiens	33-36
28774348-13	2017	CONCLUSIONS: Our findings indicate that induction of EMT, increased migration and survival depend, in MCF-7 and H460 cells, on the release of FHC control on two pathways, namely the iron/ROS metabolism and CXCR4/CXCL12 axis.	Iron	182-186	low density lipoprotein receptor	Homo sapiens	142-145
31054269-2	2019	The most common cause is hereditary haemochromatosis (HH), a genetic disorder triggered by inactivation of the iron hormone hepcidin, which results in hyperferraemia and excessive tissue iron deposition.	Iron	187-191	hepcidin antimicrobial peptide	Homo sapiens	124-132
28758951-0	2017	Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	83-91
30946781-5	2019	Cyg11 transcription is upregulated when C. reinhardtii is grown in iron-limited media, suggesting its importance in nutrient-limited environments.	Iron	67-71	uncharacterized protein	Chlamydomonas reinhardtii	0-5
28758951-10	2017	In conclusion, the hepcidin level was significantly elevated following three consecutive days of endurance training when moderate doses of iron were taken.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	19-27
30814063-0	2019	A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene.	Iron	88-92	fibroblast growth factor 6	Homo sapiens	54-58
28628474-0	2017	Prediction of human iron bioavailability using rapid c-ELISAs for human plasma hepcidin.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	79-87
28628474-1	2017	BACKGROUND: Hepcidin is the central systemic regulator of iron metabolism, but its quantification in biological fluids is challenging.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	12-20
28628474-3	2017	Our aim was to assess the ability of hepcidin as measured by three different c-ELISA assays to predict iron bioavailability in humans.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	37-45
30814063-0	2019	A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	68-76
30814063-4	2019	With this approach applied to iron overload, a strong association signal was identified between the fibroblast growth factor-encoding gene, FGF6, and hemochromatosis in the central Wisconsin population.	Iron	30-34	fibroblast growth factor 6	Homo sapiens	140-144
28702562-7	2017	Cr, Fe and Co doping result in a ferro-magnetic ground state configuration of the ReX2 structures.	Iron	4-6	RNA exonuclease 2	Homo sapiens	82-86
30814063-5	2019	Functional validation showed that fibroblast growth factor 6 protein (FGF-6) regulates iron homeostasis and induces transcriptional regulation of hepcidin.	Iron	87-91	fibroblast growth factor 6	Homo sapiens	34-60
30814063-5	2019	Functional validation showed that fibroblast growth factor 6 protein (FGF-6) regulates iron homeostasis and induces transcriptional regulation of hepcidin.	Iron	87-91	fibroblast growth factor 6	Homo sapiens	70-75
28840060-9	2017	While in H2O2 treated SH-SY5Y cells, the increased iron uptake and reduced iron release, in correlation with levels of DMT1(-IRE) and ferroportin 1, resulted in heavy iron accumulation, the FtMt overexpressing cells didn"t show any significant changes in levels of iron transport proteins and in the level of LIP.	Iron	75-79	ferritin mitochondrial	Homo sapiens	190-194
30814063-6	2019	Moreover, specific identified FGF6 variants differentially impact iron metabolism.	Iron	66-70	fibroblast growth factor 6	Homo sapiens	30-34
28840060-10	2017	These results implicate a neuroprotective role of FtMt on H2O2-induced oxidative stress, which may provide insights into the treatment of iron accumulation associated neurodegenerative diseases.	Iron	138-142	ferritin mitochondrial	Homo sapiens	50-54
31380163-2	2019	Here, CoFe hydroxide/carbon nanohybrid is reported as an efficient oxygen evolution electrocatalyst derived from the in situ formed molecular Fe-salen complexes and Co2+ ions at a low temperature of 160  C. It has been evidenced that Fe-salen as a molecular precursor facilitates the confined-growth of metal hydroxides, while Co2+ plays a critical role in catalyzing the transformation of organic ligand into nanocarbons and constitutes an essential component for CoFe hydroxide.	Iron	8-10	complement C2	Homo sapiens	165-168
31380163-2	2019	Here, CoFe hydroxide/carbon nanohybrid is reported as an efficient oxygen evolution electrocatalyst derived from the in situ formed molecular Fe-salen complexes and Co2+ ions at a low temperature of 160  C. It has been evidenced that Fe-salen as a molecular precursor facilitates the confined-growth of metal hydroxides, while Co2+ plays a critical role in catalyzing the transformation of organic ligand into nanocarbons and constitutes an essential component for CoFe hydroxide.	Iron	8-10	complement C2	Homo sapiens	327-330
31087927-6	2019	When the initial Cd2+ concentration was increased from 0 mg L-1 to approximately 200 mg L-1, the Cd2+ adsorption capacity of the Fe-modified biochar declined from 43.17 mg g-1 to 27.88 mg g-1, which was still higher than that of the unmodified biochar by at least 10 mg g-1.	Iron	129-131	CD2 molecule	Homo sapiens	17-20
28686458-0	2017	Tri-Substituted Triazole-Enabled C-H Activation of Benzyl and Aryl Amines by Iron Catalysis.	Iron	77-81	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
31087927-6	2019	When the initial Cd2+ concentration was increased from 0 mg L-1 to approximately 200 mg L-1, the Cd2+ adsorption capacity of the Fe-modified biochar declined from 43.17 mg g-1 to 27.88 mg g-1, which was still higher than that of the unmodified biochar by at least 10 mg g-1.	Iron	129-131	CD2 molecule	Homo sapiens	97-100
28648056-2	2017	Recently, human mitoNEET has been shown to be implicated in Fe/S cluster repair of cytosolic iron regulatory protein 1 (IRP1), a key regulator of cellular iron homeostasis in mammalian cells.	Iron	93-97	CDGSH iron sulfur domain 1	Homo sapiens	16-24
31087927-7	2019	In aqueous media with a high concentration of Ca2+, the Fe-modified biochar showed better Cd2+ adsorption performance; thus, compared to MnO2 and ZnO, Fe2O3 was the best choice to enhance the heavy metal adsorption performance of the sewage sludge-derived biochar.	Iron	56-58	CD2 molecule	Homo sapiens	90-93
30193381-0	2019	Cord Blood Erythropoietin and Hepcidin Reflect Lower Newborn Iron Stores due to Maternal Obesity during Pregnancy.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	30-38
28448900-6	2017	ICP-AES analysis was done to determine the amount of iron content in the MCP nanogels.	Iron	53-57	capping actin protein, gelsolin like	Homo sapiens	73-76
30193381-2	2019	In adults, both iron depletion and hypoxia stimulate erythropoietin (Epo) production, while hepcidin, the primary iron regulator, is inhibited by Epo and stimulated by obesity.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	92-100
30193381-3	2019	To understand this relationship in fetuses, we investigated obesity, inflammation, and fetal iron status on fetal Epo and hepcidin levels.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	122-130
30895493-4	2019	The essential role of CP in iron metabolism in humans is particularly evident in the case of loss-of-function mutations in the CP gene resulting in a neurodegenerative syndrome known as aceruloplasminaemia.	Iron	28-32	ceruloplasmin	Homo sapiens	22-24
28299633-2	2017	The recent development of automated systems for hematology analysis has made it possible to measure reticulocyte hemoglobin equivalent (RET-He), which is thought to reflect iron content in reticulocytes, in the same sample used for complete blood count tests.	Iron	173-177	ret proto-oncogene	Homo sapiens	136-139
28299633-12	2017	RET-He changed in parallel with changes in Hb during iron administration for 21 IDA patients.	Iron	53-57	ret proto-oncogene	Homo sapiens	0-3
30895493-4	2019	The essential role of CP in iron metabolism in humans is particularly evident in the case of loss-of-function mutations in the CP gene resulting in a neurodegenerative syndrome known as aceruloplasminaemia.	Iron	28-32	ceruloplasmin	Homo sapiens	127-129
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	17-21	NFU1 iron-sulfur cluster scaffold	Homo sapiens	220-224
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	17-21	bolA family member 3	Homo sapiens	226-231
30610968-2	2019	Here, we found that the level of mTOR was increased both in wild-type mouse models with iron accumulation and transgenic mouse models (Hepc-/-) of high-turnover osteoporosis with iron accumulation.	Iron	88-92	mechanistic target of rapamycin kinase	Mus musculus	33-37
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	17-21	iron-sulfur cluster assembly 2	Homo sapiens	243-248
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	185-189	NFU1 iron-sulfur cluster scaffold	Homo sapiens	220-224
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	185-189	bolA family member 3	Homo sapiens	226-231
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	185-189	iron-sulfur cluster assembly 2	Homo sapiens	243-248
28651647-6	2017	Iron accumulation and oxidative stress are able to aggregate some proteins, including Abeta and alpha-synuclein, which play a critical role in Alzheimer"s and Parkinson"s diseases, respectively.	Iron	0-4	synuclein alpha	Homo sapiens	96-111
30610968-2	2019	Here, we found that the level of mTOR was increased both in wild-type mouse models with iron accumulation and transgenic mouse models (Hepc-/-) of high-turnover osteoporosis with iron accumulation.	Iron	179-183	mechanistic target of rapamycin kinase	Mus musculus	33-37
30610968-5	2019	These findings revealed the role of mTOR in osteogenesis and angiogenesis in high-turnover osteoporosis with iron accumulation and showed that rapamycin targeting of mTOR ameliorates osteogenesis and angiogenesis to improve bone mass.	Iron	109-113	mechanistic target of rapamycin kinase	Mus musculus	36-40
29606929-5	2017	In addition, myoglobin variants incorporating manganese- or cobalt-porphyrins were found capable of catalyzing an intermolecular carbene C-H insertion reaction involving phthalan and ethyl alpha-diazoacetate, a reaction not supported by iron-based myoglobins and previously accessed only using iridium-based (bio)catalysts.	Iron	237-241	myoglobin	Homo sapiens	13-22
31939215-2	2019	Twelve new iron(III) complexes with the general formula [Fe(Ln )X].mCH3 CN (n=1-10; X=N3 - , NCS- or NCSe- ; m=0-2) have been synthesized, and spectrally as well as structurally characterized.	Iron	11-20	caspase 7	Mus musculus	67-71
28663751-0	2017	Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages.	Iron	76-80	lactotransferrin	Bos taurus	0-11
28663751-1	2017	Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation.	Iron	51-55	lactotransferrin	Bos taurus	6-17
28663751-1	2017	Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation.	Iron	51-55	HLF transcription factor, PAR bZIP family member	Homo sapiens	19-22
28747430-1	2017	Ferredoxin reductase (FDXR), a target of p53, modulates p53-dependent apoptosis and is necessary for steroidogenesis and biogenesis of iron-sulfur clusters.	Iron	135-139	transformation related protein 53, pseudogene	Mus musculus	41-44
31939215-2	2019	Twelve new iron(III) complexes with the general formula [Fe(Ln )X].mCH3 CN (n=1-10; X=N3 - , NCS- or NCSe- ; m=0-2) have been synthesized, and spectrally as well as structurally characterized.	Iron	57-59	caspase 7	Mus musculus	67-71
28747430-7	2017	Finally, we found that p53 played a role in iron homeostasis and was required for FDXR-mediated iron metabolism.	Iron	44-48	transformation related protein 53, pseudogene	Mus musculus	23-26
30653415-9	2019	Additionally, protein levels of alpha-actinin and alphaII-spectrin at 240 kDa were lower in the iron-loaded group.	Iron	96-100	spectrin alpha, non-erythrocytic 1	Mus musculus	50-66
28583206-16	2017	Mosquitoes respond to viral infection, by inducing expression of heavy chain ferritin, which sequesters available iron, reducing its availability to virus infected cells.	Iron	114-118	ferritin heavy chain 1	Homo sapiens	65-76
30653415-10	2019	Ryanodine receptor stabilizing subunit calstabin1 was also lower following iron loading.	Iron	75-79	FK506 binding protein 1a	Mus musculus	39-49
30653415-13	2019	This study demonstrates that a pathophysiological elevation in the skeletal muscle iron load leads to force deficits that coincide with impaired redox status, structural integrity, and lower ryanodine receptor-associated calstabin1 in the absence of muscle mass changes or oxidative damage.	Iron	83-87	FK506 binding protein 1a	Mus musculus	221-231
31002094-1	2019	Lactoferrin (LTF), also called lactotransferrin, is an iron-binding protein and member of transferrin family, whereas beta-LG is an important milk protein and belongs to the ligand-binding protein family of lipocalins and binds retinol.	Iron	55-59	lactotransferrin	Equus asinus	31-47
28551638-12	2017	Since beta-catenin is also known to be a component of wingless/Int-1-Frizzled signaling that also leads to transcriptional c-MYC activation, the pathway found here might be alternatively used by melanoma cells for iron supply, necessary for cell proliferation.	Iron	214-218	catenin beta 1	Homo sapiens	6-18
28551638-12	2017	Since beta-catenin is also known to be a component of wingless/Int-1-Frizzled signaling that also leads to transcriptional c-MYC activation, the pathway found here might be alternatively used by melanoma cells for iron supply, necessary for cell proliferation.	Iron	214-218	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	123-128
28328181-3	2017	Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	131-139
28328181-3	2017	Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	131-139
30597563-2	2019	In AI, iron metabolism is altered, as high levels of inflammation-induced hepcidin reduce the amount of iron available for erythropoiesis.	Iron	7-11	hepcidin antimicrobial peptide	Homo sapiens	74-82
28387022-4	2017	Physiological iron balance is tightly controlled at the cellular and systemic level by iron regulatory proteins (IRP1, IRP2) and the iron regulatory hormone hepcidin, respectively.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	157-165
28387022-7	2017	We discuss the function and regulation of hepcidin by various stimuli, and highlight hepcidin-dependent and -independent mechanisms that link iron utilization with maturation of erythroid progenitor cells.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	85-93
30597563-2	2019	In AI, iron metabolism is altered, as high levels of inflammation-induced hepcidin reduce the amount of iron available for erythropoiesis.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	74-82
30597563-13	2019	The increase in hepcidin levels after transfusion can further decrease iron release from intracellular storage making it available for erythropoiesis.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	16-24
30821980-2	2019	These room-temperature, one-pot, environmentally friendly procedures replace costly Rh2 catalysts and, in some instances, display important differences with comparable Rh2- and Fe-supported reactions.	Iron	177-179	Rh associated glycoprotein	Homo sapiens	84-87
27932449-8	2017	The inverse relation between baseline CRP and hepcidin levels and the haemoglobin response suggests that CRP or hepcidin measurements could influence decisions on whether iron should be given orally or intravenously.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	112-120
28678687-1	2017	Ceruloplasmin (CP) is mainly synthesized by hepatocytes and plays an essential role in iron metabolism.	Iron	87-91	ceruloplasmin	Homo sapiens	0-13
28678687-1	2017	Ceruloplasmin (CP) is mainly synthesized by hepatocytes and plays an essential role in iron metabolism.	Iron	87-91	ceruloplasmin	Homo sapiens	15-17
30996848-8	2019	It was strongly and positively correlated with ferritin (P&lt;0.001), while hemoglobin, serum iron, and total iron binding capacity were negatively correlated with hepcidin (P=0.016, 0.022 and &lt;0.001, respectively).	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	164-172
27834478-7	2017	Impaired iron export is related to inflammation and metabolic derangements that appear to impact on iron regulators, such as hepcidin, ferroportin and to a lesser degree on transferrin receptor, ferritin or copper.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	125-133
27834478-7	2017	Impaired iron export is related to inflammation and metabolic derangements that appear to impact on iron regulators, such as hepcidin, ferroportin and to a lesser degree on transferrin receptor, ferritin or copper.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	125-133
31380306-2	2019	Under such ground, this study was carried out to explore the efficiency of two conjugation methods in binding iron nanoparticles to an antibody produced against PSCA (prostate stem cell antigen) using in vitro labeling of PC3 cells.	Iron	110-114	prostate stem cell antigen	Homo sapiens	161-165
31380306-2	2019	Under such ground, this study was carried out to explore the efficiency of two conjugation methods in binding iron nanoparticles to an antibody produced against PSCA (prostate stem cell antigen) using in vitro labeling of PC3 cells.	Iron	110-114	prostate stem cell antigen	Homo sapiens	167-193
31380306-4	2019	Ultimately, Iron staining was done by anti-PSCA antibody-dexSPIONs in PC3 cells to detect antibody binding to the cells.	Iron	12-16	prostate stem cell antigen	Homo sapiens	43-47
28641612-1	2017	OBJECTIVE: To study the expression of hypoxia inducible factor 1alpha(HIF-1alpha) of iron-overloaded in irradiated mice and its effect on erythropoiesis.	Iron	85-89	hypoxia inducible factor 1, alpha subunit	Mus musculus	38-80
28641612-11	2017	mTOR inhibitor rapamycin can partially alleviate the injury, suggesting that iron overload can lead to injury of erythropoiesis through HIF-1alpha.	Iron	77-81	mechanistic target of rapamycin kinase	Mus musculus	0-4
31380306-7	2019	Conclusion: This oriented conjugation method promoted the efficiency of targeting tumor antigens, and the presence of iron particles might enhance MRI image intensity in vivo by targeting PSCA-overexpressing cells in future studies.	Iron	118-122	prostate stem cell antigen	Homo sapiens	188-192
28641612-11	2017	mTOR inhibitor rapamycin can partially alleviate the injury, suggesting that iron overload can lead to injury of erythropoiesis through HIF-1alpha.	Iron	77-81	hypoxia inducible factor 1, alpha subunit	Mus musculus	136-146
30761559-7	2019	Iron overload has been associated with oxidative stress, advanced fibrosis and decreased survival, and promising therapies beyond phlebotomy and oral iron chelation have included hepcidin agonists.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	179-187
30586625-0	2019	Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation.	Iron	91-95	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-25
28412361-5	2017	INCB14943 binds to heme iron in IDO1 protein through the oxime nitrogen.	Iron	24-28	indoleamine 2,3-dioxygenase 1	Homo sapiens	32-36
30053508-11	2019	In addition, HIF-2alpha translation is controlled by iron regulatory protein (IRP) activity, providing another level of interdependence between iron and oxygen homeostasis.	Iron	53-57	endothelial PAS domain protein 1	Homo sapiens	13-23
28487917-3	2017	An Fe-doped CoP nanosheet array (Fe-CoP/CC) is used as a bifunctional catalyst for both AOR and hydrogen evolution reaction (HER).	Iron	3-5	caspase recruitment domain family member 16	Homo sapiens	12-15
30055235-1	2019	Many past and recent advances in the field of iron metabolism have relied upon the discovery of divalent metal transporter 1, DMT1 in 1997.	Iron	46-50	solute carrier family 11 member 2	Homo sapiens	126-130
28487917-4	2017	The Fe-CoP/CC Fe-CoP/CC couple requires a cell voltage of 1.51 V to drive 20 mA cm-2 in 1.0 M KOH containing AE; however, a cell volatge of 1.63 V is required to drive the same current density in the absence of AE.	Iron	4-6	caspase recruitment domain family member 16	Homo sapiens	7-10
28487917-4	2017	The Fe-CoP/CC Fe-CoP/CC couple requires a cell voltage of 1.51 V to drive 20 mA cm-2 in 1.0 M KOH containing AE; however, a cell volatge of 1.63 V is required to drive the same current density in the absence of AE.	Iron	4-6	caspase recruitment domain family member 16	Homo sapiens	17-20
28538180-0	2017	Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.	Iron	20-24	egl-9 family hypoxia-inducible factor 3	Mus musculus	87-133
30055235-2	2019	DMT1 is the major iron transporter and contributes non-heme iron uptake in most types of cell.	Iron	18-22	solute carrier family 11 member 2	Homo sapiens	0-4
28538180-7	2017	We reveal that duodenal Regnase-1 controls the expression of PHD3, which impairs duodenal iron uptake via HIF2alpha suppression.	Iron	90-94	egl-9 family hypoxia-inducible factor 3	Mus musculus	61-65
30055235-3	2019	Each DMT1 isoform exhibits different expression patterns in cell-type specificity and distinct subcellular distribution, which enables cells to uptake both transferrin-bound and non-transferrin-bound irons efficiently.	Iron	200-205	solute carrier family 11 member 2	Homo sapiens	5-9
28538180-7	2017	We reveal that duodenal Regnase-1 controls the expression of PHD3, which impairs duodenal iron uptake via HIF2alpha suppression.	Iron	90-94	endothelial PAS domain protein 1	Mus musculus	106-115
30055235-4	2019	DMT1 expression is regulated by iron through the translational and degradation pathways to ensure iron homeostasis.	Iron	32-36	solute carrier family 11 member 2	Homo sapiens	0-4
30055235-4	2019	DMT1 expression is regulated by iron through the translational and degradation pathways to ensure iron homeostasis.	Iron	98-102	solute carrier family 11 member 2	Homo sapiens	0-4
30055235-5	2019	It is considered that mammalian iron transporters including DMT1 cannot transport ferric iron but ferrous iron.	Iron	98-110	solute carrier family 11 member 2	Homo sapiens	60-64
30055235-8	2019	We summarize DMT1 expression depending on the types of cell or tissue and the function and mechanism of one of the iron chaperones, PCBP2.	Iron	115-119	solute carrier family 11 member 2	Homo sapiens	13-17
28452474-3	2017	Previous work has suggested that alpha-synuclein can catalyze the reduction of iron as a ferrireductase.	Iron	79-83	synuclein alpha	Homo sapiens	33-48
30107217-3	2019	Iron supply to the heart is dependent on systemic iron availability which is controlled by the systemic hepcidin/ferroportin axis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	104-112
30107217-3	2019	Iron supply to the heart is dependent on systemic iron availability which is controlled by the systemic hepcidin/ferroportin axis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	104-112
28334935-11	2017	In contrast, the iron-raising allele of PPP1R3B was associated with higher levels of fasting glucose (P = 7.70 x 10-7) and fasting insulin (P = 4.79 x 10-6), but these associations were not attenuated upon adjustment for TIBC-so iron is not likely a mediator.	Iron	17-21	protein phosphatase 1 regulatory subunit 3B	Homo sapiens	40-47
28334935-11	2017	In contrast, the iron-raising allele of PPP1R3B was associated with higher levels of fasting glucose (P = 7.70 x 10-7) and fasting insulin (P = 4.79 x 10-6), but these associations were not attenuated upon adjustment for TIBC-so iron is not likely a mediator.	Iron	229-233	protein phosphatase 1 regulatory subunit 3B	Homo sapiens	40-47
30107217-6	2019	It also highlights a newly-recognised mechanism of intracellular iron homeostasis in cardiomyocytes, based on a cell-autonomous cardiac hepcidin/ferroportin axis.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	136-144
30266734-0	2019	Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice.	Iron	28-32	erythropoietin	Mus musculus	45-59
28437101-2	2017	Four-coordinate iron complexes of the type (ArL)FeX2 [ArL = 1,9-(2,4,6-Ph3C6H2)2-5-mesityldipyrromethene] with X = Cl or tBuO were prepared and found to be high-spin (S = 5/2), as determined by superconducting quantum interference device magnetometry, electron paramagnetic resonance, and 57Fe Mossbauer spectroscopy.	Iron	16-20	stabilin 2	Homo sapiens	48-52
29909454-11	2019	OGDR and iron reduced the cell viability and increased the expression of TLR-4 associated proteins (RIP3, MyD88, phospho-NF-kB, and release of IL-6) in BMVECs from diabetic animals.	Iron	9-13	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	106-111
28469240-0	2017	Capacity of humic substances to complex with iron at different salinities in the Yangtze River estuary and East China Sea.	Iron	45-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	118-121
31031367-2	2019	Hepcidin is thought to regulate iron metabolism by iron blockade through various mechanisms.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
28622776-4	2017	Hepcidin synthesis is increased during the acute inflammation phase; leading to decreased iron intestinal absorption and retention of the metal within macrophages.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
28622780-3	2017	The understanding of the molecular and cellular mechanisms allowing iron level to be kept at physiological concentration has greatly progressed in recent years, in particular with the identification of the iron-regulatory hormone, hepcidin and its receptor ferroportin, the sole iron exporter known to date.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	231-239
28622780-3	2017	The understanding of the molecular and cellular mechanisms allowing iron level to be kept at physiological concentration has greatly progressed in recent years, in particular with the identification of the iron-regulatory hormone, hepcidin and its receptor ferroportin, the sole iron exporter known to date.	Iron	206-210	hepcidin antimicrobial peptide	Homo sapiens	231-239
28622783-12	2017	Also, hepcidin measurements appeared an interesting marker for diagnosing iron deficiency and identifying individuals in need of iron supplementation in populations where inflammatory or infectious diseases are frequently encountered.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	6-14
31031367-2	2019	Hepcidin is thought to regulate iron metabolism by iron blockade through various mechanisms.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	0-8
30690945-10	2019	Our study findings may suggest that high levels of hepcidin may cause iron dysregulation in ADHD patients.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	51-59
28282554-2	2017	The objective of the study was to examine splenic ERFE and liver TMPRSS6 synthesis in rats treated with a combination of iron and erythropoietin (EPO).	Iron	121-125	erythropoietin	Rattus norvegicus	146-149
32255103-0	2019	Simultaneous sensing of ferritin and apoferritin proteins using an iron-responsive dye and evaluation of physiological parameters associated with serum iron estimation.	Iron	67-71	ferritin heavy chain 1	Homo sapiens	37-48
28282554-5	2017	Iron pretreatment prevented the EPO-induced decrease in hepcidin expression.	Iron	0-4	erythropoietin	Rattus norvegicus	32-35
28282554-9	2017	EPO administration increased TMPRSS6 content in the plasma membrane-enriched fraction of liver homogenate; in iron-pretreated rats, this increase was abolished.	Iron	110-114	erythropoietin	Rattus norvegicus	0-3
28282554-10	2017	The results confirm that iron pretreatment prevents the EPO-induced decrease in liver Hamp expression.	Iron	25-29	erythropoietin	Rattus norvegicus	56-59
32255103-1	2019	An iron-responsive optical probe has been developed for simultaneous sensing of both ferritin and apoferritin proteins at pH 7.4 in water.	Iron	3-7	ferritin heavy chain 1	Homo sapiens	98-109
28430959-1	2017	Staphylococcus aureus iron-regulated surface protein A (IsdA) is a fibrinogen and fibronectin adhesin that also contributes to iron sequestration and resistance to innate immunity.	Iron	22-26	fibronectin 1	Bos taurus	82-93
32255103-3	2019	In contrast, apoferritin dissociates the preformed iron complex and revives the green colored fluorescence of the native probe (turn-on signal).	Iron	51-55	ferritin heavy chain 1	Homo sapiens	13-24
28430959-1	2017	Staphylococcus aureus iron-regulated surface protein A (IsdA) is a fibrinogen and fibronectin adhesin that also contributes to iron sequestration and resistance to innate immunity.	Iron	127-131	fibronectin 1	Bos taurus	82-93
30804804-7	2019	The cytoprotective effects of HO-1 depend on several cellular mechanisms including the generation of bilirubin, an anti-oxidant molecule, from the degradation of heme; the induction of ferritin, a strong chelator of free iron; and the release of CO, that displays multiple anti-inflammatory and anti-apoptotic actions.	Iron	221-225	heme oxygenase 1	Homo sapiens	30-34
28027576-1	2017	Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell-specific function and regulation are still elusive.	Iron	31-35	solute carrier family 40 member 1	Homo sapiens	13-17
28027576-2	2017	This study examined FPN1 expression in human macrophages, the cells that are primarily responsible on a daily basis for plasma iron turnover and are central in the pathogenesis of ferroportin disease (FD), the disease attributed to lack-of-function FPN1 mutations.	Iron	127-131	solute carrier family 40 member 1	Homo sapiens	20-24
28027576-7	2017	However, when FD macrophages were exposed to large amounts of heme iron, in contrast to donor and p.A69T macrophages, FPN1 could no longer reach the cell surface, leading to intracellular iron retention.	Iron	67-71	solute carrier family 40 member 1	Homo sapiens	118-122
30478858-10	2019	In contrast, BMP6 is absolutely required for hepcidin regulation by serum iron.	Iron	74-78	bone morphogenetic protein 6	Mus musculus	13-17
28027576-7	2017	However, when FD macrophages were exposed to large amounts of heme iron, in contrast to donor and p.A69T macrophages, FPN1 could no longer reach the cell surface, leading to intracellular iron retention.	Iron	188-192	solute carrier family 40 member 1	Homo sapiens	118-122
28027576-9	2017	However, in FD, FPN1 fails to reach the cell surface when cells undergo high iron turnover.	Iron	77-81	solute carrier family 40 member 1	Homo sapiens	16-20
28551910-3	2017	IV iron also affects the oxidation of plasma proteins, including b2M.	Iron	3-7	beta-2-microglobulin	Homo sapiens	65-68
30325535-7	2019	The gene signature designed from AML patients overexpressing FTH1 revealed a significant enrichment in genes of the immune and inflammatory response including Nf-KB pathway, oxidative stress, or iron pathways.	Iron	195-199	ferritin heavy chain 1	Homo sapiens	61-65
28370936-4	2017	Six redox enzymes are involved, including four alpha-ketoglutarate- and iron(II)-dependent dioxygenases that hydroxylate four sp3 carbons; one flavin-dependent dehydrogenase that is involved in formation of the unsaturated lactone; and the ferric-reductase-like enzyme RbtH, which regioselectively reduces one of the maleic anhydride moieties in rubratoxin B to the gamma-hydroxybutenolide that is critical for PP2A inhibition.	Iron	72-76	protein phosphatase 2 phosphatase activator	Homo sapiens	411-415
28219939-4	2017	We have confirmed that Prx1 from the puffer fish and humans truly possesses a catalase (CAT)-like activity that is independent of Cys residues and reductants, but dependent on iron.	Iron	176-180	peroxiredoxin 1	Homo sapiens	23-27
30289974-2	2019	GPx4 is the major inhibitor of ferroptosis, a non-apoptotic and iron-dependent programmed cell death pathway, which has been shown to occur in various neurological disorders with severe oxidative stress.	Iron	64-68	glutathione peroxidase 4	Homo sapiens	0-4
28421060-3	2017	HO-1 catalyzes the rate-limiting step in the conversion of heme into iron, biliverdin and the gasotransmitter carbon monoxide (CO), all of which share anti-apoptotic, anti-inflammatory, pro-survival, and tumorigenic activities.	Iron	69-73	heme oxygenase 1	Homo sapiens	0-4
30383083-0	2019	Neurodegeneration With Brain Iron Accumulation: A Novel Mutation in the Ceruloplasmin Gene.	Iron	29-33	ceruloplasmin	Homo sapiens	72-85
28139396-7	2017	These beneficial effects of HO-1 induction during AKI are mediated in part by the by-products of the HO reaction (iron, carbon monoxide, and bile pigments).	Iron	114-118	heme oxygenase 1	Homo sapiens	28-32
30510168-2	2019	Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	90-98
28029503-2	2017	Hepcidin, a peptide hormone mostly produced by the liver, controls the absorption and regulation of iron.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-8
30510168-2	2019	Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling.	Iron	77-81	bone morphogenetic protein 1	Homo sapiens	158-161
30439579-3	2019	Comparatively, the R1 and R3 were continuously subjected to the 1.0 V DC electric field via a reactive Fe anode and an inert Ti-Ir/Rh anode, respectively, while the R2 without DC exposure.	Iron	103-105	CD1b molecule	Homo sapiens	19-28
28284299-3	2017	This anemia is related to high hepcidin concentrations resulting in iron-restricted erythropoiesis, and decreased erythropoietin concentrations.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	31-39
28284299-4	2017	A new hormone (erythroferrone) has been identified, which mediates hepcidin suppression to allow increased iron absorption and mobilization from iron stores.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	67-75
28284299-4	2017	A new hormone (erythroferrone) has been identified, which mediates hepcidin suppression to allow increased iron absorption and mobilization from iron stores.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	67-75
30465671-7	2019	Most studies investigating the relationship of Cu, Fe and Zn with alpha-synuclein have relied on the use of recombinant protein and there is little evidence that the interaction between metals and alpha-synuclein are physiologically relevant.	Iron	51-53	synuclein alpha	Homo sapiens	66-81
27121697-11	2017	CONCLUSION: Iron chelation by oral deferiprone has a renoprotective effect in DN rats by relieving oxidative stress, inflammation, and fibrosis, which is related to the cytokines NF-kappaB, MCP-1, MMP-9, TIMP-1, COX-2, and nitrotyrosine.	Iron	12-16	C-C motif chemokine ligand 2	Rattus norvegicus	190-195
28188131-7	2017	Our data support the hypothesis that the improvement of inflammatory anemia by MMB results from inhibition of ACVR1-mediated hepcidin expression in the liver, which leads to increased mobilization of sequestered iron from cellular stores and subsequent stimulation of erythropoiesis.	Iron	212-216	hepcidin antimicrobial peptide	Homo sapiens	125-133
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	secreted phosphoprotein 1	Homo sapiens	153-157
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	secreted phosphoprotein 1	Homo sapiens	158-162
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	secreted phosphoprotein 1	Homo sapiens	158-162
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	secreted phosphoprotein 1	Homo sapiens	158-162
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	secreted phosphoprotein 1	Homo sapiens	158-162
28265627-0	2017	Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*], and [{Cp*Fe(bdt)}2(trans-mu-eta1:eta1-S2)].	Iron	67-71	secreted phosphoprotein 1	Homo sapiens	158-162
28327200-1	2017	BACKGROUND: Hepcidin plays a central role in iron homeostasis and erythropoiesis.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	12-20
28327200-2	2017	Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow transferrin-mediated iron transport to the bone marrow.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	13-21
28327200-2	2017	Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow transferrin-mediated iron transport to the bone marrow.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	13-21
28263600-2	2017	RuCl2(PPh3)3 has been proven to be the most efficient catalyst for this transformation when compared to a range of other Cu-, Pd-, or Fe-based catalyst systems.	Iron	134-136	protein phosphatase 4 catalytic subunit	Homo sapiens	6-10
27958708-0	2017	Iron, Copper, and Zinc Concentration in Abeta Plaques in the APP/PS1 Mouse Model of Alzheimer"s Disease Correlates with Metal Levels in the Surrounding Neuropil.	Iron	0-4	amyloid beta (A4) precursor protein	Mus musculus	40-45
27958708-0	2017	Iron, Copper, and Zinc Concentration in Abeta Plaques in the APP/PS1 Mouse Model of Alzheimer"s Disease Correlates with Metal Levels in the Surrounding Neuropil.	Iron	0-4	presenilin 1	Mus musculus	65-68
27958708-1	2017	The metal ions of iron, copper, and zinc have long been associated with the aggregation of beta-amyloid (Abeta) plaques in Alzheimer"s disease; an interaction that has been suggested to promote increased oxidative stress and neuronal dysfunction.	Iron	18-22	amyloid beta (A4) precursor protein	Mus musculus	105-110
28287455-9	2017	A recent study shows that the archaeal s4U synthetase (ThiI) and the eukaryotic cytosolic 2-thiouridine synthetase (Ncs6) are Fe-S enzymes; this expands the role of Fe-S enzymes in tRNA thiolation to the Archaea and Eukarya domains.	Iron	126-128	cytosolic thiouridylase subunit 1	Homo sapiens	116-120
28287455-9	2017	A recent study shows that the archaeal s4U synthetase (ThiI) and the eukaryotic cytosolic 2-thiouridine synthetase (Ncs6) are Fe-S enzymes; this expands the role of Fe-S enzymes in tRNA thiolation to the Archaea and Eukarya domains.	Iron	165-167	cytosolic thiouridylase subunit 1	Homo sapiens	116-120
28682031-9	2017	PUF clinical results for the treatment of chronic congestive heart failure have demonstrated effectiveness in improving the clinical condition with reduction of NYHA class and improvement of FE%, the reduction of days of hospitalization, in reducing mortality, improving quality patient"s life.	Iron	191-193	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	0-3
27927768-0	2017	Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.	Iron	0-4	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	10-15
27927768-4	2017	To address whether Bach1 is involved in the responses of erythroblasts to iron status, low iron conditions that induced severe iron deficiency in mice were established.	Iron	74-78	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	19-24
27927768-6	2017	Bach1-/- mice showed more severe iron deficiency anemia in the developmental phase of mice and a retarded recovery once iron was replenished when compared with wild-type mice.	Iron	33-37	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	0-5
27927768-9	2017	These findings reveal the principle role of iron as a regulator of gene expression in erythroblast maturation and suggest that the iron-heme-Bach1 axis is important for a proper adaptation of erythroblast to iron deficiency to avoid toxic aggregates of non-heme globin.	Iron	44-48	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	141-146
27927768-9	2017	These findings reveal the principle role of iron as a regulator of gene expression in erythroblast maturation and suggest that the iron-heme-Bach1 axis is important for a proper adaptation of erythroblast to iron deficiency to avoid toxic aggregates of non-heme globin.	Iron	131-135	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	141-146
27927768-9	2017	These findings reveal the principle role of iron as a regulator of gene expression in erythroblast maturation and suggest that the iron-heme-Bach1 axis is important for a proper adaptation of erythroblast to iron deficiency to avoid toxic aggregates of non-heme globin.	Iron	131-135	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	141-146
28005311-13	2017	2 and 6 mum ELT increased Tfr1 and Slc11a2 (iron-responsive genes involved in neuronal iron uptake) mRNA levels, indicating neuronal ID.	Iron	44-48	solute carrier family 11 member 2	Homo sapiens	35-42
28005311-13	2017	2 and 6 mum ELT increased Tfr1 and Slc11a2 (iron-responsive genes involved in neuronal iron uptake) mRNA levels, indicating neuronal ID.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	35-42
28030490-10	2017	Iron supplementation prevented wound infection (n = 30, p &lt; 0.0001) and decreased HIF1alpha (p = 0.039643).	Iron	0-4	hypoxia inducible factor 1, alpha subunit	Mus musculus	85-94
28166432-2	2017	In the present study, the histochemical expression of iron in liver and spleen sections of CD-1 mice (aged 8 weeks) was quantified, 24 h after intravenous administration of polyacrylic acid-coated IONs (PAA-coated IONs) (8, 20, 50 mg/kg).	Iron	54-58	CD1 antigen complex	Mus musculus	91-95
28275731-3	2017	Single-particle chemical analysis for hundreds of individual atmospheric particles collected over the East China Sea shows that Fe-rich particles from coal combustion and steel industries were coated with thick layers of sulfate after 1 to 2 days of atmospheric residence.	Iron	128-130	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	113-116
28955733-10	2017	GENERAL SIGNIFICANCE: These results suggest that exogenous PP IX disrupts iron metabolism by decreasing the protein expression levels of PAP7, DMT1 and C/EBPalpha.	Iron	74-78	solute carrier family 11 member 2	Homo sapiens	143-147
28367088-13	2017	These results suggest that the increased expression of DMT1 induces iron overload and iron overload induces osteoblast autophagy and apoptosis, thus affecting the pathological processes of osteoporosis.	Iron	68-72	solute carrier family 11 member 2	Homo sapiens	55-59
28261264-6	2017	An altered pattern of iron transporters with iron overload is highlighted in BPAN human fibroblasts, supporting for a role of DMT1 in NBIA.	Iron	22-26	solute carrier family 11 member 2	Homo sapiens	126-130
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	signal transducer and activator of transcription 5A	Homo sapiens	152-157
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	signal transducer and activator of transcription 5A	Homo sapiens	159-164
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	ferritin heavy chain 1	Homo sapiens	308-328
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	ferritin heavy chain 1	Homo sapiens	330-333
28216591-7	2017	Genes encoding chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), leucoanthocyanidin dioxygenase (LDOX), and anthocyanin O-methyltransferase (AOMT) exhibited higher transcript levels in berries from plants cultivated with 46 muM Fe compared to the ones cultivated with other Fe concentrations.	Iron	235-237	flavonoid 3',5'-methyltransferase	Vitis vinifera	115-146
28216591-7	2017	Genes encoding chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), leucoanthocyanidin dioxygenase (LDOX), and anthocyanin O-methyltransferase (AOMT) exhibited higher transcript levels in berries from plants cultivated with 46 muM Fe compared to the ones cultivated with other Fe concentrations.	Iron	281-283	flavonoid 3',5'-methyltransferase	Vitis vinifera	115-146
28169552-1	2017	Lactoferrin (Lf) is an iron-binding multifunctional protein, mainly present in external secretions.	Iron	23-27	HLF transcription factor, PAR bZIP family member	Homo sapiens	13-15
28169560-1	2017	Lactoferrin (Lf) is an iron-binding glycoprotein that is present at high concentrations in milk.	Iron	23-27	lactotransferrin	Bos taurus	0-11
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	Iron	71-75	Tis11p	Saccharomyces cerevisiae S288C	105-109
28057442-0	2017	Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.	Iron	0-4	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	15-19
28057442-0	2017	Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.	Iron	79-83	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	15-19
28057442-2	2017	Ceruloplasmin/hephaestin double knockout mice (Cp/Heph DKO) and hepcidin knockout mice (Hepc KO) accumulate retinal iron and model some features of AMD.	Iron	116-120	ceruloplasmin	Mus musculus	0-13
28057442-11	2017	These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation.	Iron	96-100	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	25-29
28057442-11	2017	These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation.	Iron	138-142	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	25-29
28143953-7	2017	The expression levels of hemoglobin-haptoglobin receptor CD163 and hemopexin receptor CD91 were drastically reduced in both liver and spleen, resulting in heme- and hemoglobin-derived iron elimination in urine.	Iron	184-188	hemopexin	Mus musculus	67-76
28151915-0	2017	Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.	Iron	36-40	hemojuvelin BMP co-receptor	Homo sapiens	51-62
28151915-0	2017	Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.	Iron	36-40	hemojuvelin BMP co-receptor	Homo sapiens	69-72
28151915-4	2017	This prompted us to study whether there is an association between hypertension and another iron overload-associated gene, hemojuvelin (HJV), which has 2 common polymorphic sites (rs 16827043, rs7536827).The study included 336 hypertensive cases and 480 controls.	Iron	91-95	hemojuvelin BMP co-receptor	Homo sapiens	122-133
28151915-4	2017	This prompted us to study whether there is an association between hypertension and another iron overload-associated gene, hemojuvelin (HJV), which has 2 common polymorphic sites (rs 16827043, rs7536827).The study included 336 hypertensive cases and 480 controls.	Iron	91-95	hemojuvelin BMP co-receptor	Homo sapiens	135-138
27817091-2	2017	We report the case of a patient with hereditary ceruloplasmin deficiency due to a novel gene mutation in ceruloplasmin gene (CP), treated with fresh frozen plasma (FFP) and iron chelation therapy.	Iron	173-177	ceruloplasmin	Homo sapiens	48-61
27817091-2	2017	We report the case of a patient with hereditary ceruloplasmin deficiency due to a novel gene mutation in ceruloplasmin gene (CP), treated with fresh frozen plasma (FFP) and iron chelation therapy.	Iron	173-177	ceruloplasmin	Homo sapiens	125-127
28286877-0	2017	IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.	Iron	15-19	interleukin 22	Mus musculus	0-5
28286877-3	2017	Using an unbiased proteomic approach to understand the mechanistic basis of IL-22 dependent iron retention in the host, we have identified that IL-22 induces the production of the plasma hemoglobin scavenger haptoglobin and heme scavenger hemopexin.	Iron	92-96	interleukin 22	Mus musculus	76-81
28286877-3	2017	Using an unbiased proteomic approach to understand the mechanistic basis of IL-22 dependent iron retention in the host, we have identified that IL-22 induces the production of the plasma hemoglobin scavenger haptoglobin and heme scavenger hemopexin.	Iron	92-96	interleukin 22	Mus musculus	144-149
28118841-2	2017	Copper deficiency, which leads to a defect in ceruloplasmin enzymatic activity, has a strong effect on iron homeostasis resulting in cellular iron retention.	Iron	103-107	ceruloplasmin	Homo sapiens	46-59
28118841-2	2017	Copper deficiency, which leads to a defect in ceruloplasmin enzymatic activity, has a strong effect on iron homeostasis resulting in cellular iron retention.	Iron	142-146	ceruloplasmin	Homo sapiens	46-59
28118841-4	2017	RESULTS: We show that copper deficiency and the inflammatory cytokine interleukin-6 have different effects on the expression of proteins involved in iron and copper metabolism such as the soluble and glycosylphosphtidylinositol anchored forms of ceruloplasmin, hepcidin, ferroportin1, transferrin receptor1, divalent metal transporter1 and H-ferritin subunit.	Iron	149-153	ceruloplasmin	Homo sapiens	246-259
28118841-4	2017	RESULTS: We show that copper deficiency and the inflammatory cytokine interleukin-6 have different effects on the expression of proteins involved in iron and copper metabolism such as the soluble and glycosylphosphtidylinositol anchored forms of ceruloplasmin, hepcidin, ferroportin1, transferrin receptor1, divalent metal transporter1 and H-ferritin subunit.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	261-269
28118841-4	2017	RESULTS: We show that copper deficiency and the inflammatory cytokine interleukin-6 have different effects on the expression of proteins involved in iron and copper metabolism such as the soluble and glycosylphosphtidylinositol anchored forms of ceruloplasmin, hepcidin, ferroportin1, transferrin receptor1, divalent metal transporter1 and H-ferritin subunit.	Iron	149-153	solute carrier family 40 member 1	Homo sapiens	271-283
27883261-9	2017	On the contrary, iron supplementation had no effect on the penetrance of NTDs in Lrp2 mutant embryos and negated the preventative effect of folic acid supplementation in Lrp2null/null mutants.	Iron	17-21	low density lipoprotein receptor-related protein 2	Mus musculus	170-174
30465671-9	2019	In addition, we examined the ability of dityrosine cross-linked alpha-synuclein oligomers to bind Cu, Fe and Zn.	Iron	102-104	synuclein alpha	Homo sapiens	64-79
30723395-4	2019	The process of misfolding and aggregation of neuronal proteins such as alpha-synuclein, Tau, amyloid beta (Abeta), TDP-43 or SOD1 is a common hallmark of many neurodegenerative disorders and iron has been shown to facilitate protein aggregation.	Iron	191-195	synuclein alpha	Homo sapiens	71-86
28138322-6	2017	After treatment with rapamycin, the iron loading-induced increase in the alpha-synuclein level was significantly reversed and ROS generation was alleviated in both cultured neurons and SH-SY5Y cells.	Iron	36-40	synuclein alpha	Homo sapiens	73-88
28138322-7	2017	These results indicate that the inhibition of autophagy is critical for the pathological alterations in alpha-synuclein induced by iron loading.	Iron	131-135	synuclein alpha	Homo sapiens	104-119
28138322-9	2017	Together, our study shows that autophagy dysfunction contributes to iron-induced alpha-synuclein pathology.	Iron	68-72	synuclein alpha	Homo sapiens	81-96
27794422-1	2017	Hepcidin is a small cysteine-rich signaling peptide that regulates blood serum iron concentrations [1-4].	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	0-8
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	82-86	PTEN induced putative kinase 1	Mus musculus	17-22
28072870-11	2017	The model obtained is a function of time and the initial apical iron concentration, with a linear component that captures the global tendency of the system, and a non-linear component that can be associated to the movement of DMT1 transporters.	Iron	64-68	doublesex and mab-3 related transcription factor 1	Homo sapiens	226-230
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	191-195	PTEN induced putative kinase 1	Mus musculus	17-22
29666474-3	2019	Other members of the CDGSH iron sulfur domain (CISD) family include mitoNEET/CISD1 and Miner2/CISD3.	Iron	27-31	CDGSH iron sulfur domain 1	Homo sapiens	68-76
29666474-3	2019	Other members of the CDGSH iron sulfur domain (CISD) family include mitoNEET/CISD1 and Miner2/CISD3.	Iron	27-31	CDGSH iron sulfur domain 1	Homo sapiens	77-82
30808215-0	2019	The Antithrombin Effect of Ankaferd Hemostat (ABS) Is Related to the High Iron Content of the Medicine.	Iron	74-78	serpin family C member 1	Homo sapiens	4-16
28068331-10	2017	In contrast, ferroportin regulation by hepcidin is the predominant mechanism of iron homeostasis in response to changing iron diets for a big range of dietary iron contents.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	39-47
28068331-10	2017	In contrast, ferroportin regulation by hepcidin is the predominant mechanism of iron homeostasis in response to changing iron diets for a big range of dietary iron contents.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	39-47
28068331-10	2017	In contrast, ferroportin regulation by hepcidin is the predominant mechanism of iron homeostasis in response to changing iron diets for a big range of dietary iron contents.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	39-47
30336942-7	2019	RESULTS: For CTP detection, the AUC was up to 0.10 higher with greyscale, 0.67+-0.02 (standard error), compared to rainbow, 0.56+-0.02, and detection with hot-iron was in between (0.61+-0.03).	Iron	159-163	solute carrier family 25 member 1	Homo sapiens	13-16
27836545-2	2017	Recently, GPX4 has been investigated as a target molecule that induces iron-dependent cell death (ferroptosis) selectively in cancer cells that express mutant Ras.	Iron	71-75	glutathione peroxidase 4	Homo sapiens	10-14
31280251-0	2019	The role of hepcidin in regulating iron homeostasis in selected diseases.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	12-20
27870532-0	2017	Distinguishing the Protonation State of the Histidine Ligand to the Oxidized Iron-Sulfur Cluster from the MitoNEET Family of Proteins.	Iron	77-81	CDGSH iron sulfur domain 1	Homo sapiens	106-114
27870532-1	2017	The iron-sulfur cluster located in the recently discovered human mitoNEET protein (and related proteins) is structurally similar to the more well-known ferredoxin and Rieske clusters.	Iron	4-8	CDGSH iron sulfur domain 1	Homo sapiens	65-73
27870532-2	2017	Although its biological function is uncertain, the iron-sulfur cluster in mitoNEET has been proposed to undergo proton-coupled electron transfer involving the histidine ligand to the cluster.	Iron	51-55	CDGSH iron sulfur domain 1	Homo sapiens	74-82
31280251-2	2019	The latest studies in iron metabolism, especially the involvement of hepcidin, which is the main regulator of iron homeostasis, broadened our knowledge in many medical fields (immunology, nephrology, hematology, gastrology).	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	69-77
31280251-2	2019	The latest studies in iron metabolism, especially the involvement of hepcidin, which is the main regulator of iron homeostasis, broadened our knowledge in many medical fields (immunology, nephrology, hematology, gastrology).	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	69-77
30326385-7	2019	Here, the addition of iron as a factor significantly improved the regression model between the two endotoxin assays, explaining 77% of the variation of the TLR4 stimulation and excluding the significant effect of land use class.	Iron	22-26	toll like receptor 4	Homo sapiens	156-160
28514781-0	2017	Hepcidin: Homeostasis and Diseases Related to Iron Metabolism.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
28514781-1	2017	Iron is an essential metal for cell survival that is regulated by the peptide hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	86-94
28514781-3	2017	Genetic alterations influence the serum hepcidin concentration, which can lead to an iron overload in tissues, as observed in haemochromatosis, in which serum hepcidin or defective hepcidin synthesis is observed.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	40-48
28514781-3	2017	Genetic alterations influence the serum hepcidin concentration, which can lead to an iron overload in tissues, as observed in haemochromatosis, in which serum hepcidin or defective hepcidin synthesis is observed.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	159-167
28514781-3	2017	Genetic alterations influence the serum hepcidin concentration, which can lead to an iron overload in tissues, as observed in haemochromatosis, in which serum hepcidin or defective hepcidin synthesis is observed.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	159-167
28514781-4	2017	Another genetic imbalance of iron is iron-refractory anaemia, in which serum concentrations of hepcidin are increased, precluding the flow and efflux of extra- and intracellular iron.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	95-103
28514781-4	2017	Another genetic imbalance of iron is iron-refractory anaemia, in which serum concentrations of hepcidin are increased, precluding the flow and efflux of extra- and intracellular iron.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	95-103
30326385-8	2019	Moreover, the effect of iron proved to be more than a correlation, since dosing LPS with Fe2+ led to an increase up to 64% in TLR4 stimulation, while Fe2+ without LPS was unable to stimulate a response.	Iron	24-28	toll like receptor 4	Homo sapiens	126-130
28514781-4	2017	Another genetic imbalance of iron is iron-refractory anaemia, in which serum concentrations of hepcidin are increased, precluding the flow and efflux of extra- and intracellular iron.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	95-103
28514781-9	2017	This review describes the main pathways of systemic and genetic regulation of hepcidin, as well as its influence on the disorders related to iron metabolism.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	78-86
31519530-0	2019	Predicting hepcidin level using inflammation markers and iron indicators in patients with anemia of chronic disease.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	11-19
28051796-10	2017	NAFLD patients with hepatic iron deposition exhibited higher hepcidin expression (3.1 fold, p = 0.04) but lower expression of cytokines.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	61-69
31519530-1	2019	BACKGROUND: Recently, a small peptide called Hepcidin, was found to have an important role in regulating the iron metabolism in anemia of chronic disease (ACD) patients.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	45-53
28051796-11	2017	In conclusion, we observed elevated hepatic HAMP expression in patients with NASH and in NAFLD patients who had hepatic iron deposition, while proinflammatory cytokines displayed elevated expression only in patients with NASH, suggesting a regulatory role for hepcidin in NAFL to NASH transition and in mitigating inflammatory responses.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	44-48
31519530-3	2019	Therefore, our study aims to predict the level of hepcidin serum using inflammation markers and iron indicators in patients afflicted with ACD and observe how this severity of inflammation separated the level of interleukin-6 (IL-6), as well the as hepcidin level.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	50-58
27905193-2	2017	Hepcidin is a key regulator of systemic iron balance.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
31018712-8	2019	Moreover, plasma noradrenaline concentrations, which reflected sympathetic nervous activity, tended to increase, and leptin levels were significantly decreased in FE-exposed mice.	Iron	163-165	leptin	Mus musculus	117-123
28052347-3	2017	Apoptotic effect of iron-free bovine lactoferrin inhibited the growth of HeLa cells after 48 hours of treatment while the diferric-bLf was ineffective in the concentration range tested (from 1 to 12.5 muM).	Iron	20-24	lactotransferrin	Bos taurus	37-48
29176318-0	2017	CCL2 is Upregulated by Decreased miR-122 Expression in Iron-Overload-Induced Hepatic Inflammation.	Iron	55-59	microRNA 122	Mus musculus	33-40
31018712-10	2019	In the hypothalamus, brain-derived neurotrophic factor protein levels and glucose-1-phosphate concentrations were decreased in the FE group.	Iron	131-133	brain derived neurotrophic factor	Mus musculus	21-54
31018712-12	2019	These neurohormonal and immunological changes in the FE-exposed mice suggested that the FE may activate the hypothalamus/sympathetic nerve/leptin axis and immune system, thereby retarding tumor growth.	Iron	53-55	leptin	Mus musculus	139-145
31018712-12	2019	These neurohormonal and immunological changes in the FE-exposed mice suggested that the FE may activate the hypothalamus/sympathetic nerve/leptin axis and immune system, thereby retarding tumor growth.	Iron	88-90	leptin	Mus musculus	139-145
28204974-5	2017	Ferroptosis is an iron-dependent non-apoptotic cell death that can elicited by pharmacological inhibiting the cystine/glutamate antiporter, system Xc- (type I) or directly binding and loss of activity of GPx4 (Type II) in cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression, but not in normal cells.	Iron	18-22	glutathione peroxidase 4	Mus musculus	204-208
28204974-5	2017	Ferroptosis is an iron-dependent non-apoptotic cell death that can elicited by pharmacological inhibiting the cystine/glutamate antiporter, system Xc- (type I) or directly binding and loss of activity of GPx4 (Type II) in cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression, but not in normal cells.	Iron	18-22	transformation related protein 53, pseudogene	Mus musculus	283-286
30466936-10	2019	A negative correlation was found between Cu concentration and catalase activity (r = -0.22, p &lt; 0.05); Fe content was negatively correlated with GPx and GST activities (r = -0.32, r = -0.22, respectively, p &lt; 0.05).	Iron	106-108	glutathione S-transferase kappa 1	Homo sapiens	156-159
28204974-9	2017	In our established GPx4-deficient MEF cells, depletion of GPx4 induce iron and 15LOX-independent lipid peroxidation at 26 h and caspase-independent cell death at 72 h, whereas erastin and RSL3 treatment resulted in iron-dependent ferroptosis by 12 h. These results indicated the possibility that the mechanism of GPx4-depleted cell death might be different from that of ferroptosis induced by erastin and RSL3.	Iron	70-74	glutathione peroxidase 4	Mus musculus	58-62
28204974-9	2017	In our established GPx4-deficient MEF cells, depletion of GPx4 induce iron and 15LOX-independent lipid peroxidation at 26 h and caspase-independent cell death at 72 h, whereas erastin and RSL3 treatment resulted in iron-dependent ferroptosis by 12 h. These results indicated the possibility that the mechanism of GPx4-depleted cell death might be different from that of ferroptosis induced by erastin and RSL3.	Iron	70-74	glutathione peroxidase 4	Mus musculus	58-62
28204974-9	2017	In our established GPx4-deficient MEF cells, depletion of GPx4 induce iron and 15LOX-independent lipid peroxidation at 26 h and caspase-independent cell death at 72 h, whereas erastin and RSL3 treatment resulted in iron-dependent ferroptosis by 12 h. These results indicated the possibility that the mechanism of GPx4-depleted cell death might be different from that of ferroptosis induced by erastin and RSL3.	Iron	215-219	glutathione peroxidase 4	Mus musculus	58-62
28204974-9	2017	In our established GPx4-deficient MEF cells, depletion of GPx4 induce iron and 15LOX-independent lipid peroxidation at 26 h and caspase-independent cell death at 72 h, whereas erastin and RSL3 treatment resulted in iron-dependent ferroptosis by 12 h. These results indicated the possibility that the mechanism of GPx4-depleted cell death might be different from that of ferroptosis induced by erastin and RSL3.	Iron	215-219	glutathione peroxidase 4	Mus musculus	58-62
30342981-0	2019	Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced alpha-synuclein aggregation.	Iron	68-72	synuclein alpha	Homo sapiens	81-96
30402883-7	2019	VL cases had decreased iron uptake by transferrin-dependent and transferrin-independent routes while elevated hepcidin, degraded sole iron exporter ferroportin.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	110-118
30402883-8	2019	Therefore, it appears that perturbation in iron homoeostasis has essential role in HLA-DR mediated antigen presentation and innate armoury by downregulating iNOS as well as altering IFN-gamma, IL-6 and IL-10 profiles.	Iron	43-47	inositol-3-phosphate synthase 1	Homo sapiens	157-161
30402883-9	2019	CONCLUSION: The iron homoeostasis by hepcidin can serve as one of the crucial determinants for regulating immune cell signalling; therefore, targeting iron metabolism, specifically hepcidin alone or in combination with agonists, can serve to clear infection.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	37-45
30402883-9	2019	CONCLUSION: The iron homoeostasis by hepcidin can serve as one of the crucial determinants for regulating immune cell signalling; therefore, targeting iron metabolism, specifically hepcidin alone or in combination with agonists, can serve to clear infection.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	181-189
30402883-9	2019	CONCLUSION: The iron homoeostasis by hepcidin can serve as one of the crucial determinants for regulating immune cell signalling; therefore, targeting iron metabolism, specifically hepcidin alone or in combination with agonists, can serve to clear infection.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	181-189
29956370-5	2019	Liver iron overload causes increased production of hepcidin and elevated plasma levels, which can activate macrophages of atherosclerotic plaques.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	51-59
30606409-5	2019	Hepcidin serves as the master regulator of iron homeostasis through its ability to regulate ferroportin-mediated iron export and intracellular H-ferritin levels.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
30606409-5	2019	Hepcidin serves as the master regulator of iron homeostasis through its ability to regulate ferroportin-mediated iron export and intracellular H-ferritin levels.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798811-3	2019	Aberrantly increased hepcidin leads to systemic iron deficiency and/or iron restricted erythropoiesis.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	21-29
30798811-4	2019	Furthermore, insufficiently elevated hepcidin occurs in multiple diseases associated with iron overload.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	37-45
30798812-0	2019	Cardiomyocyte hepcidin: From intracellular iron homeostasis to physiological function.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	14-22
30798812-6	2019	However, new evidence reveals that cardiomyocyte hepcidin is indispensable for the control of intracellular iron levels, normal metabolism and heart function.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	49-57
30798813-4	2019	Genetic polymorphisms of the HFE gene (rs1800562, rs1799945 and rs1800730) also affect the normal activity of another protein, hepcidin, a negative regulator of iron homeostasis.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	127-135
30798814-2	2019	Hepcidin regulates iron homeostasis by controlling iron export from absorptive enterocytes, hepatocytes, and macrophages into the circulation via ferroportin inactivation.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798814-2	2019	Hepcidin regulates iron homeostasis by controlling iron export from absorptive enterocytes, hepatocytes, and macrophages into the circulation via ferroportin inactivation.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798814-3	2019	Hepcidin is also an innate antimicrobial agent that is induced by invasive bacteria, limits bacterial proliferation by reducing iron in plasma and extracellular fluids, and kills bacteria.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798815-3	2019	Hepcidin production is modulated by several factors, as hypoxia/anemia, erythropoietin and erythropoiesis products, transferrin saturation (TSAT) and liver iron levels, which are altered in CKD.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798815-6	2019	Considering the actual alerts about risk of iron overload in dialysis patients, inhibition of hepcidin, the central key player in iron homeostasis, could be a pivotal strategy in the management of CKD anemia.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	94-102
30798815-6	2019	Considering the actual alerts about risk of iron overload in dialysis patients, inhibition of hepcidin, the central key player in iron homeostasis, could be a pivotal strategy in the management of CKD anemia.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	94-102
30798816-2	2019	Hepcidin, the master iron regulator has been shown to be regulated by a number of physiological stimuli and their associated signaling pathways.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798816-3	2019	This chapter will summarize our current understanding of how these physiological stimuli and downstream signaling molecules are involved in hepcidin modulation and ultimately contribute to the regulation of systemic or local iron homeostasis.	Iron	225-229	hepcidin antimicrobial peptide	Homo sapiens	140-148
30798816-4	2019	The signaling pathways and molecules described here have been shown to primarily affect hepcidin at a transcriptional level, but these transcriptional changes correlate with changes in systemic iron levels as well, supporting the functional effects of hepcidin regulation by these signaling pathways.	Iron	194-198	hepcidin antimicrobial peptide	Homo sapiens	252-260
30798817-1	2019	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798817-1	2019	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798817-2	2019	Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	16-24
30798817-2	2019	Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	16-24
30798817-2	2019	Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	16-24
30798817-4	2019	The BMP type I receptors ALK2 and ALK3 are responsible for iron-dependent hepcidin upregulation and basal hepcidin expression, respectively.	Iron	59-63	bone morphogenetic protein 1	Homo sapiens	4-7
30798817-4	2019	The BMP type I receptors ALK2 and ALK3 are responsible for iron-dependent hepcidin upregulation and basal hepcidin expression, respectively.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	74-82
30798817-5	2019	Characterization of animal models with genetic inactivation of the key components of the pathway has suggested the existence of two BMP/SMAD pathway branches: the first ALK3 and HH proteins dependent, responsive to BMP2 for basal hepcidin activation, and the second ALK2 dependent, activated by BMP6 in response to increased tissue iron.	Iron	332-336	bone morphogenetic protein 1	Homo sapiens	132-135
30811139-0	2019	[Investigation of the iron-binding capacity of the bovine lactoferrin].	Iron	22-26	lactotransferrin	Bos taurus	58-69
30811139-1	2019	In this work, studies were carried out to obtain and determine the iron-binding ability of lactoferrin isolated from milk of Holstein-Friesian (black-and-white) breed of cows, which is the main stock of the Russian cattle herd (CH).	Iron	67-71	lactotransferrin	Bos taurus	91-102
30811139-2	2019	Aim of the study was to obtain lactoferrin and determine its iron-binding capacity for substantiating the raw material resources of its industrial production as an easily digestible source of ferrous iron for the production of dietary supplements and/or specialized foods.	Iron	200-204	lactotransferrin	Bos taurus	31-42
30811139-6	2019	Iron-binding capacity was determined in apo- and holoforms of lactoferrin.	Iron	0-4	lactotransferrin	Bos taurus	62-73
30583467-7	2018	The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator.	Iron	142-146	heme oxygenase 1	Homo sapiens	108-112
30583467-7	2018	The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator.	Iron	142-146	heme oxygenase 1	Homo sapiens	171-175
30575774-1	2018	Lactoferrin (LF) is an 80 KDa iron-binding glycoprotein that plays a significant role in the innate immune system and is considered to be an important microbicide molecule.	Iron	30-34	HLF transcription factor, PAR bZIP family member	Homo sapiens	13-15
30577543-6	2018	Moreover, we examined the relation between hepcidin secretion and intracellular iron content.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	43-51
30055098-0	2018	Baseline hepcidin measurement in the differential diagnosis of anaemia for elderly patients and its correlation with the increment of transferrin saturation following an oral iron absorption test.	Iron	175-179	hepcidin antimicrobial peptide	Homo sapiens	9-17
30055098-3	2018	The secondary objective was to assess whether baseline hepcidin concentrations correlated with the relative increase of transferrin saturation (TS) after an oral iron absorption test (OIAT).	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	55-63
30055098-13	2018	Conclusions Baseline hepcidin levels could be a useful tool to identify ID in anaemic elderly patients and may predict acute iron response following OIAT.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	21-29
30544952-7	2018	Hence, inflammation-driven hepcidin elevation causes iron retention in cells and tissues.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	27-35
30194723-1	2018	Iron-sulfur cluster biogenesis is a complex process mediated by numerous proteins among which two from bacteria chaperones, called HscB and HscA in bacteria.	Iron	0-4	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	131-135
27743328-6	2017	The content of zerovalent iron decreased after Cd2+ adsorption as a result of iron oxidation during Cd2+ adsorption.	Iron	26-30	CD2 molecule	Homo sapiens	47-50
28943547-1	2018	Hereditary hemochromatosis and beta-thalassemia can both result in the inappropriately low production of the hormone hepcidin, which leads to an increase in intestinal absorption and excessive iron deposition in the parenchymal cells.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	117-125
27743328-6	2017	The content of zerovalent iron decreased after Cd2+ adsorption as a result of iron oxidation during Cd2+ adsorption.	Iron	26-30	CD2 molecule	Homo sapiens	100-103
27743328-6	2017	The content of zerovalent iron decreased after Cd2+ adsorption as a result of iron oxidation during Cd2+ adsorption.	Iron	78-82	CD2 molecule	Homo sapiens	47-50
27743328-6	2017	The content of zerovalent iron decreased after Cd2+ adsorption as a result of iron oxidation during Cd2+ adsorption.	Iron	78-82	CD2 molecule	Homo sapiens	100-103
30506659-0	2018	In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen.	Iron	32-36	glutathione-disulfide reductase	Rattus norvegicus	144-165
28182038-6	2017	Iron status influenced hepcidin levels of patients.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	23-31
30506659-5	2018	The aim of this study is to provide a better in vivo and in vitro understanding of how long-term iron overload affects the gene expression and activities of some antioxidant enzymes, such as glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) in the spleen.	Iron	97-101	glutathione-disulfide reductase	Rattus norvegicus	278-299
28182038-9	2017	Iron status of patients also influenced interaction between hepcidin and hemoglobin (Hb).	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	60-68
28182038-10	2017	Hepcidin correlated negatively with Hb in patients with sufficient iron status (r = -0.7452, P &lt; 0.0001) but nearly correlated positively with Hb in patients with absolute iron deficiency (r = 0.9428, P = 0.0572).	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
30506659-5	2018	The aim of this study is to provide a better in vivo and in vitro understanding of how long-term iron overload affects the gene expression and activities of some antioxidant enzymes, such as glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) in the spleen.	Iron	97-101	glutathione-disulfide reductase	Rattus norvegicus	301-303
28182038-14	2017	Furthermore, iron status modifies hepcidin level and its association with Hb.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	34-42
30555088-6	2018	Solute carrier family-11 member-2 (SLC11A2) functions to transport ferrous iron and some divalent metal ions throughout the plasmamembrane and across endosomalmembranes.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	0-33
28182038-15	2017	Raised hepcidin can predict the need for parenteral iron therapy and need for higher dose of recombinant human EPO to overcome iron-restricted erythropoiesis.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	7-15
28182038-15	2017	Raised hepcidin can predict the need for parenteral iron therapy and need for higher dose of recombinant human EPO to overcome iron-restricted erythropoiesis.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	7-15
30555088-6	2018	Solute carrier family-11 member-2 (SLC11A2) functions to transport ferrous iron and some divalent metal ions throughout the plasmamembrane and across endosomalmembranes.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	35-42
27815981-1	2017	The coordination of nitrite in myoglobin (Mb) has been characterized by resonance Raman spectroscopy and the frequencies of the nitrite bound to the heme Fe as well to the 2-vinyl have been computed by density functional theory (DFT) calculations.	Iron	154-156	myoglobin	Homo sapiens	31-40
30555088-7	2018	Functional polymorphisms in the SLC11A2 gene have been reported to cause excess storage of iron, resulting in iron overload.	Iron	91-95	solute carrier family 11 member 2	Homo sapiens	32-39
30555088-7	2018	Functional polymorphisms in the SLC11A2 gene have been reported to cause excess storage of iron, resulting in iron overload.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	32-39
29923651-1	2018	AIM: Hepcidin is a central regulator of iron homeostasis.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	5-13
30517728-12	2018	Conclusion: Hepcidin was not associated with hemoglobin genotype, but there may be a difference in the way hepcidin responds to iron status among those with either sickle cell trait or homozygous alpha+-thalassemia in young Kenyan children.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	107-115
30501711-1	2018	OBJECTIVE: To study the effects of iron metabolism abnormality on EPO-STAT5 signaling pathway in anemia patients.	Iron	35-39	signal transducer and activator of transcription 5A	Homo sapiens	70-75
30501711-5	2018	Moreover, the effects of iron metabolism abnormality on the expression of EPO and STAT5 in anemia patients were analyzed.	Iron	25-29	signal transducer and activator of transcription 5A	Homo sapiens	82-87
30501711-6	2018	RESULTS: compared with non-iron over load group, the EPO level in iron over load group significantly increased (P&lt;0.05), the expression of STAT5 mRNA and P-STAT5 significantly decreased (P&lt;0.05).	Iron	27-31	signal transducer and activator of transcription 5A	Homo sapiens	142-147
30501711-6	2018	RESULTS: compared with non-iron over load group, the EPO level in iron over load group significantly increased (P&lt;0.05), the expression of STAT5 mRNA and P-STAT5 significantly decreased (P&lt;0.05).	Iron	27-31	signal transducer and activator of transcription 5A	Homo sapiens	159-164
30501711-7	2018	After iron chelation therapy, the EPO level in serum significantly decreased (P&lt;0.05), the expression of STAT5 mRNA and P-STAT5 was up-regulated significantly (P&lt;0.05).	Iron	6-10	signal transducer and activator of transcription 5A	Homo sapiens	108-113
30501711-7	2018	After iron chelation therapy, the EPO level in serum significantly decreased (P&lt;0.05), the expression of STAT5 mRNA and P-STAT5 was up-regulated significantly (P&lt;0.05).	Iron	6-10	signal transducer and activator of transcription 5A	Homo sapiens	125-130
30501711-10	2018	CONCLUSION: The excessive iron load or chronic inflammation may inhibit the activation of EPO-STAT5 signaling pathway and aggravate the anemia.	Iron	26-30	signal transducer and activator of transcription 5A	Homo sapiens	94-99
30209118-5	2018	We generated a murine model of thalassemia intermedia specifically lacking BM Tfr2: because their erythroid cells are more susceptible to EPO stimulation, mice show improved erythropoiesis and red blood cell morphology as well as partial correction of anemia and iron overload.	Iron	263-267	erythropoietin	Mus musculus	138-141
30524291-5	2018	Furthermore, we found that ROS levels and transferrin expression were elevated in CRC cells treated with RSL3 accompanied by a decrease in the expression of glutathione peroxidase 4 (GPX4), indicating an iron-dependent cell death, ferroptosis.	Iron	204-208	glutathione peroxidase 4	Homo sapiens	183-187
30469412-8	2018	Given that hepcidin decrease may improve intestinal iron absorption, these results warrant further investigation in a larger cohort and especially in patients with IDA.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	11-19
30469435-1	2018	Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
30469435-1	2018	Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	0-8
30469435-2	2018	Genetic defects in iron signaling to hepcidin lead to "hepcidinopathies" ranging from hereditary hemochromatosis to iron-refractory iron deficiency anemia, which are disorders caused by hepcidin deficiency or excess, respectively.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	37-45
30469435-2	2018	Genetic defects in iron signaling to hepcidin lead to "hepcidinopathies" ranging from hereditary hemochromatosis to iron-refractory iron deficiency anemia, which are disorders caused by hepcidin deficiency or excess, respectively.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	37-45
30469435-3	2018	Moreover, dysregulation of hepcidin is a pathogenic cofactor in iron-loading anemias with ineffective erythropoiesis and in anemia of inflammation.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	27-35
30571460-7	2018	After 12 weeks of Western diet, Jak2 VF lesions showed increased complexity, with larger necrotic cores, defective efferocytosis, prominent iron deposition, and costaining of erythrocytes and macrophages, suggesting erythrophagocytosis.	Iron	140-144	Janus kinase 2	Mus musculus	32-36
30269025-11	2018	The present experiment provides novel insights into the molecular mechanisms underlying induction of hepcidin by inflammation and alteration of iron homeostasis.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	101-109
28820043-2	2018	In this study, we explored the use of aluminum-iron alloys particles in millimeter scale for rapid removal of CHCl3, CCl4 and TCE from water.	Iron	47-51	C-C motif chemokine ligand 4	Homo sapiens	117-121
30341696-12	2018	As consequence recent novel therapeutic drugs for neurodegenerative diseases has led to the development of multi target drugs, that possess selective brain MAO A and B inhibitory moiety, iron chelating and antioxidant activities and the ability to increase brain levels of endogenous neurotrophins, such as BDNF, GDNF VEGF and erythropoietin and induce mitochondrial biogenesis.	Iron	187-191	monoamine oxidase A	Homo sapiens	156-167
30245128-0	2018	Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2alpha concentrations in renal interstitial fibroblasts.	Iron	0-4	erythropoietin	Mus musculus	16-30
30245128-0	2018	Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2alpha concentrations in renal interstitial fibroblasts.	Iron	0-4	endothelial PAS domain protein 1	Mus musculus	56-101
30245128-2	2018	Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues.	Iron	8-12	erythropoietin	Mus musculus	122-136
30245128-2	2018	Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues.	Iron	8-12	erythropoietin	Mus musculus	138-141
30245128-2	2018	Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues.	Iron	152-156	erythropoietin	Mus musculus	122-136
30245128-2	2018	Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues.	Iron	152-156	erythropoietin	Mus musculus	138-141
30245128-4	2018	We found that intraperitoneal injection of iron-dextran caused severe iron deposition in renal interstitial fibroblasts, the site of Epo production.	Iron	43-47	erythropoietin	Mus musculus	133-136
30245128-5	2018	Iron overload induced by either intraperitoneal injection or feeding decreased activity of endogenous Epo gene expression by reducing levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the major transcriptional activator of the Epo gene.	Iron	0-4	erythropoietin	Mus musculus	102-105
30245128-5	2018	Iron overload induced by either intraperitoneal injection or feeding decreased activity of endogenous Epo gene expression by reducing levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the major transcriptional activator of the Epo gene.	Iron	0-4	endothelial PAS domain protein 1	Mus musculus	144-189
30245128-5	2018	Iron overload induced by either intraperitoneal injection or feeding decreased activity of endogenous Epo gene expression by reducing levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the major transcriptional activator of the Epo gene.	Iron	0-4	endothelial PAS domain protein 1	Mus musculus	191-200
30245128-5	2018	Iron overload induced by either intraperitoneal injection or feeding decreased activity of endogenous Epo gene expression by reducing levels of hypoxia-inducible transcription factor 2alpha (HIF2alpha), the major transcriptional activator of the Epo gene.	Iron	0-4	erythropoietin	Mus musculus	246-249
30245128-6	2018	Administration of an iron-deficient diet to the anemic mice reduced serum iron to normal concentration and enhanced the ability of renal Epo production.	Iron	21-25	erythropoietin	Mus musculus	137-140
30245128-7	2018	These results demonstrate that iron overload due to Epo deficiency attenuates endogenous Epo gene expression in the kidneys.	Iron	31-35	erythropoietin	Mus musculus	52-55
30245128-7	2018	These results demonstrate that iron overload due to Epo deficiency attenuates endogenous Epo gene expression in the kidneys.	Iron	31-35	erythropoietin	Mus musculus	89-92
30245128-8	2018	Thus, iron suppresses Epo production by reducing HIF2alpha concentration in renal interstitial fibroblasts.	Iron	6-10	erythropoietin	Mus musculus	22-25
30245128-8	2018	Thus, iron suppresses Epo production by reducing HIF2alpha concentration in renal interstitial fibroblasts.	Iron	6-10	endothelial PAS domain protein 1	Mus musculus	49-58
30303337-6	2017	Hepcidin, the main regulator of iron homeostasis and its synthesis, is inhibited by iron deficiency and stimulated by inflammation.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
30856305-2	2017	The last decade discovery of hepcidin (regulator of iron homeostasis) and also various factors and signaling pathways regulating its metabolism the pathophysiology of anemia under chronic kidney diseases is understood significantly better.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	29-37
30856305-5	2017	The particular attention is given to hepcidin playing a key role in regulation of extra-cellular content of iron.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	37-45
30420953-1	2018	Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-derived peptide hormone.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	76-84
30374287-0	2018	The Dual Role of Hepcidin in Brain Iron Load and Inflammation.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	17-25
27756061-7	2017	Alterations in the metabolism of iron via the molecule hepcidin and ferritin are largely responsible for the consequent anaemia.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	55-63
30374287-1	2018	Hepcidin is the major regulator of systemic iron metabolism, while the role of this peptide in the brain has just recently been elucidated.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
30374287-2	2018	Studies suggest a dual role of hepcidin in neuronal iron load and inflammation.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	31-39
28978826-3	2017	The central regulator of systemic iron homeostasis is hepcidin, which is primarily produced in the liver.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	54-62
30097509-1	2018	Decreased hepcidin mobilizes iron, which facilitates erythropoiesis, but excess iron is pathogenic in beta-thalassemia.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	10-18
28978826-4	2017	Various molecules, including HFE, transferrin receptor 2 (TFR2), and hemojuvelin (HJV), are involved in sensing systemic iron status.	Iron	121-125	transferrin receptor 2	Homo sapiens	34-56
28978826-4	2017	Various molecules, including HFE, transferrin receptor 2 (TFR2), and hemojuvelin (HJV), are involved in sensing systemic iron status.	Iron	121-125	transferrin receptor 2	Homo sapiens	58-62
30287840-7	2018	Interestingly, by using ferrozine-iron sequestration and iron titration assays, we uncovered the iron sequestering capacity of PAC-1.	Iron	34-38	ADCYAP receptor type I	Homo sapiens	127-132
28978826-4	2017	Various molecules, including HFE, transferrin receptor 2 (TFR2), and hemojuvelin (HJV), are involved in sensing systemic iron status.	Iron	121-125	hemojuvelin BMP co-receptor	Homo sapiens	69-80
28978826-4	2017	Various molecules, including HFE, transferrin receptor 2 (TFR2), and hemojuvelin (HJV), are involved in sensing systemic iron status.	Iron	121-125	hemojuvelin BMP co-receptor	Homo sapiens	82-85
28978826-5	2017	Hepatocytes produce hepcidin in response to excess iron and inflammatory stimuli (e.g., interleukin-6), whereas hepcidin expression is downregulated by hypoxia, anemia, and erythropoietic activity.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	20-28
28978826-7	2017	Hepcidin downregulates the protein expression of ferroportin, the only iron exporter in mammalian cells, and thereby downregulates iron absorption from intestine and iron release from macrophages.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
28978826-7	2017	Hepcidin downregulates the protein expression of ferroportin, the only iron exporter in mammalian cells, and thereby downregulates iron absorption from intestine and iron release from macrophages.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	0-8
30287840-7	2018	Interestingly, by using ferrozine-iron sequestration and iron titration assays, we uncovered the iron sequestering capacity of PAC-1.	Iron	57-61	ADCYAP receptor type I	Homo sapiens	127-132
28978826-7	2017	Hepcidin downregulates the protein expression of ferroportin, the only iron exporter in mammalian cells, and thereby downregulates iron absorption from intestine and iron release from macrophages.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	0-8
30287840-7	2018	Interestingly, by using ferrozine-iron sequestration and iron titration assays, we uncovered the iron sequestering capacity of PAC-1.	Iron	57-61	ADCYAP receptor type I	Homo sapiens	127-132
30287840-8	2018	Additionally, the expression levels of iron shortage-related genes were also increased in PAC-1-treated cells, and iron (II) supplementation reversed all of the observed cellular responses.	Iron	39-43	ADCYAP receptor type I	Homo sapiens	90-95
30193229-1	2018	Iron transport through the duodenum is regulated by carrier proteins, one of which is the ubiquitously distributed divalent metal transporter (DMT1) which is responsible for the uptake of iron across the apical surface of the duodenal enterocyte.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	143-147
28629515-0	2017	Mutual Cross Talk Between Iron Homeostasis and Erythropoiesis.	Iron	26-30	bone morphogenetic protein receptor type 2	Homo sapiens	13-17
28629515-4	2017	The iron needed for hemoglobin synthesis is mainly ensured by inhibiting hepcidin expression, thereby increasing both ferroportin-mediated iron export from the duodenal absorptive cells and iron release from the reticuloendothelial cells that process old and/or damaged red blood cells.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	73-81
28629515-4	2017	The iron needed for hemoglobin synthesis is mainly ensured by inhibiting hepcidin expression, thereby increasing both ferroportin-mediated iron export from the duodenal absorptive cells and iron release from the reticuloendothelial cells that process old and/or damaged red blood cells.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	73-81
30193229-1	2018	Iron transport through the duodenum is regulated by carrier proteins, one of which is the ubiquitously distributed divalent metal transporter (DMT1) which is responsible for the uptake of iron across the apical surface of the duodenal enterocyte.	Iron	188-192	solute carrier family 11 member 2	Homo sapiens	143-147
28629515-4	2017	The iron needed for hemoglobin synthesis is mainly ensured by inhibiting hepcidin expression, thereby increasing both ferroportin-mediated iron export from the duodenal absorptive cells and iron release from the reticuloendothelial cells that process old and/or damaged red blood cells.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	73-81
30193229-4	2018	The differences in binding modes between ScaDMT1 and hDMT1 were noted for a set of 7 iron containing compounds, including ferrous sulphate.	Iron	85-89	solute carrier family 11 member 2	Homo sapiens	53-58
30042411-4	2018	Hepcidin, the master regulator of iron metabolism, is regulated by circulating iron levels, erythroblast secretion of erythroferrone, and inflammation.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
27873495-7	2017	RESULTS: Cell pellet imaging of Ad-hFTH in vitro showed a strong negatively enhanced contrast in T2w and T2*w images, presenting with darker signal intensity in high concentrations of Fe.	Iron	184-186	ferritin heavy chain 1	Homo sapiens	35-39
30042411-4	2018	Hepcidin, the master regulator of iron metabolism, is regulated by circulating iron levels, erythroblast secretion of erythroferrone, and inflammation.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	0-8
30042411-5	2018	Both decreased circulating iron and increased erythroferrone levels, which occur as a consequence of erythroid hyperplasia in PV, are anticipated to suppress hepcidin and enable recovery from iron deficiency.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	158-166
28203649-3	2016	We observed increased expression of heme and iron-regulated genes, previously shown to inhibit HIV-1, including ferroportin, IKBalpha, HO-1, p21, and SAM domain and HD domain-containing protein 1 (SAMHD1).	Iron	45-49	H3 histone pseudogene 16	Homo sapiens	141-144
28006025-5	2016	Functional analysis indicated that in the light group, the down-regulated iron-sulfur cluster assembly protein (Iba57) would decrease the synthesis of protoporphyrin IX; furthermore, the up-regulated protein solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5) and down-regulated translocator protein (TSPO) would lead to increased amounts of protoporphyrin IX transported into the mitochondria matrix to form heme with iron, which is supplied by ovotransferrin protein (TF).	Iron	74-78	transferrin (ovotransferrin)	Gallus gallus	496-510
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	23-27	Janus kinase 2	Mus musculus	81-85
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	23-27	Janus kinase 2	Mus musculus	96-100
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	23-27	Janus kinase 2	Mus musculus	96-100
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	23-27	erythropoietin	Mus musculus	209-223
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	171-175	Janus kinase 2	Mus musculus	81-85
28066232-3	2016	Mitochondrial ferritin (FtMt) is an iron-storage protein that is located in the mitochondria, which has a significant role in modulating cellular iron metabolism.	Iron	36-40	ferritin mitochondrial	Homo sapiens	0-22
28066232-3	2016	Mitochondrial ferritin (FtMt) is an iron-storage protein that is located in the mitochondria, which has a significant role in modulating cellular iron metabolism.	Iron	36-40	ferritin mitochondrial	Homo sapiens	24-28
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	171-175	Janus kinase 2	Mus musculus	96-100
28066232-7	2016	We found that overexpression of FtMt in neuroblastoma SH-SY5Y cells significantly inhibited erastin-induced ferroptosis, which very likely was achieved by regulation of iron homeostasis.	Iron	169-173	ferritin mitochondrial	Homo sapiens	32-36
28066232-9	2016	Consistent with that, the alterations of iron-related proteins in FtMt-overexpressed cells were different from that of the control cells.	Iron	41-45	ferritin mitochondrial	Homo sapiens	66-70
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	171-175	Janus kinase 2	Mus musculus	96-100
30042411-11	2018	Lastly, differences in iron-related parameters between PV patients and mice with JAK2 V617F and JAK2 exon 12 mutations suggest that specific regions in JAK2 may influence iron metabolism by nuanced changes of erythropoietin receptor signaling.	Iron	171-175	erythropoietin	Mus musculus	209-223
30077770-1	2018	Ceruloplasmin (Cp) is an important extracellular regulator of iron metabolism.	Iron	62-66	ceruloplasmin	Mus musculus	0-13
27818104-0	2016	Structural/Functional Properties of Human NFU1, an Intermediate [4Fe-4S] Carrier in Human Mitochondrial Iron-Sulfur Cluster Biogenesis.	Iron	104-108	NFU1 iron-sulfur cluster scaffold	Homo sapiens	42-46
27818104-1	2016	Human mitochondrial NFU1 functions in the maturation of iron-sulfur proteins, and NFU1 deficiency is associated with a fatal mitochondrial disease.	Iron	56-60	NFU1 iron-sulfur cluster scaffold	Homo sapiens	20-24
30029355-2	2018	Trace dissolved iron in oceanic surface water can limit phytoplankton growth which in turn limits the carbon dioxide flux at the air/sea interface.	Iron	16-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	133-136
28260494-2	2016	In addition to reversible O2 binding, respiratory proteins of the globin family, hemoglobin (Hb) and myoglobin (Mb), participate in redox reactions with various metal complexes, including biologically significant ones, such as those of copper and iron.	Iron	247-251	myoglobin	Homo sapiens	101-110
27671803-3	2016	METHODS AND RESULTS: We designed and developed a chimeric construct encoding for both of iron-binding human ferritin heavy chain (hFTH) controlled by the beta-catenin-responsive TCF/lymphoid-enhancer binding factor (Lef) promoter and constitutively expressed green fluorescent protein (GFP).	Iron	89-93	ferritin heavy chain 1	Homo sapiens	108-128
30295269-10	2018	CONCLUSION: Excessive oxidative stress is present in patients with HbHCS, and hepcidin is inhibited by the upregulation of EPO and sFTR, and hence involved in iron overload in patients.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	78-86
27671803-3	2016	METHODS AND RESULTS: We designed and developed a chimeric construct encoding for both of iron-binding human ferritin heavy chain (hFTH) controlled by the beta-catenin-responsive TCF/lymphoid-enhancer binding factor (Lef) promoter and constitutively expressed green fluorescent protein (GFP).	Iron	89-93	ferritin heavy chain 1	Homo sapiens	130-134
27671803-3	2016	METHODS AND RESULTS: We designed and developed a chimeric construct encoding for both of iron-binding human ferritin heavy chain (hFTH) controlled by the beta-catenin-responsive TCF/lymphoid-enhancer binding factor (Lef) promoter and constitutively expressed green fluorescent protein (GFP).	Iron	89-93	catenin beta 1	Homo sapiens	154-166
27671803-7	2016	The iron signal was absent when rats (n = 6) were chronically treated with SEN195 (10 mg/kg/day), a small-molecular inhibitor of beta-catenin/TCF-dependent gene transcription.	Iron	4-8	catenin beta 1	Rattus norvegicus	129-141
30215066-1	2018	Reported herein is a novel iron-catalyzed, DTBP-mediated carboazidation of alkenes using cycloalkanes, CH2Cl2, CHCl3 and CCl4 as alkylating reagents to generate electrophilic or nucleophilic alkyl radicals.	Iron	27-31	C-C motif chemokine ligand 4	Homo sapiens	121-125
26894412-8	2016	RESULTS: It was found that heme-centered dockings of the substrate/modulator drug molecules with the available CYP crystal structures gave poor docking geometries and distances from Fe-heme centre.	Iron	182-184	peptidylprolyl isomerase G	Homo sapiens	111-114
30104344-0	2018	S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.	Iron	57-61	solute carrier family 11 member 2	Homo sapiens	19-47
26878994-2	2016	Previous observations during phlebotomy suggest an increase in intestinal iron uptake caused by lowering of hepcidin as a result of intensive bloodletting.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	108-116
30151523-9	2018	H&amp;E staining showed Fe3O4@PDA NP-labeled NK cells, under a magnetic field, had higher intra-tumoral iron density and increased accumulation of CD56+ NK cells.	Iron	104-108	neural cell adhesion molecule 1	Homo sapiens	147-151
27329321-0	2016	Nucleic acid oxidative damage in Alzheimer"s disease-explained by the hepcidin-ferroportin neuronal iron overload hypothesis?	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	70-78
27329321-5	2016	The "hepcidin-ferroportin iron overload" AD hypothesis links these processes together and is discussed here.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	5-13
30248094-0	2018	Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney.	Iron	19-23	solute carrier family 48 member 1b	Danio rerio	0-4
27769419-2	2016	The interplay between aberrations in the structural organization and elemental composition of SN neuron bodies has recently gained in importance as selected metals: Fe, Cu, Zn, Ca were found to trigger oxidative-stress-mediated aberration in their molecular assembly due to concomitant protein (alpha-synuclein, tau-protein) aggregation, gliosis and finally oxidative stress.	Iron	165-167	synuclein alpha	Homo sapiens	295-310
29573487-0	2018	Iron Precatalysts with Bulky Tri(tert-butyl)cyclopentadienyl Ligands for the Dehydrocoupling of Dimethylamine-Borane.	Iron	0-4	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	29-32
27713040-8	2016	An imbalance between endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) expression in response to iron overload was normalized by THU, L1 or the combination treatment.	Iron	113-117	nitric oxide synthase 3, endothelial cell	Mus musculus	21-54
30294279-6	2018	The discovery of hepcidin allowed a greater knowledge of the relationships between immune cells, iron metabolism, and anemia in chronic inflammatory diseases.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	17-25
27805332-10	2016	RET-He was the only significant predictor of bone marrow iron stores (at P &lt; 0.05).	Iron	57-61	ret proto-oncogene	Homo sapiens	0-3
27805332-13	2016	CONCLUSIONS: RET-He correlated significantly with serum ferritin and is also a better predictor of bone marrow iron stores than the latter.	Iron	111-115	ret proto-oncogene	Homo sapiens	13-16
30139518-1	2018	Hepcidin is a peptide hormone and has emerged as the central molecule regulating systemic iron homeostasis.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
27599360-1	2016	Mitochondrial ferritin (FtMt) is believed to play an antioxidant role via iron regulation, and FtMt gene mutation has been reported in age-related macular degeneration (AMD).	Iron	74-78	ferritin mitochondrial	Homo sapiens	0-22
27599360-1	2016	Mitochondrial ferritin (FtMt) is believed to play an antioxidant role via iron regulation, and FtMt gene mutation has been reported in age-related macular degeneration (AMD).	Iron	74-78	ferritin mitochondrial	Homo sapiens	24-28
30327713-1	2018	Heme oxygenase 1 (Hmox1), a ubiquitous enzyme degrading heme to carbon monoxide, iron, and biliverdin, is one of the cytoprotective enzymes induced in response to a variety of stimuli, including cellular oxidative stress.	Iron	81-85	heme oxygenase 1	Homo sapiens	0-16
27732581-6	2016	Adult PLVAP-deficient mice show major alterations in macrophage-dependent iron recycling and mammary branching morphogenesis.	Iron	74-78	plasmalemma vesicle associated protein	Mus musculus	6-11
30327713-1	2018	Heme oxygenase 1 (Hmox1), a ubiquitous enzyme degrading heme to carbon monoxide, iron, and biliverdin, is one of the cytoprotective enzymes induced in response to a variety of stimuli, including cellular oxidative stress.	Iron	81-85	heme oxygenase 1	Homo sapiens	18-23
30228242-4	2018	In response to iron scarcity, the conserved Saccharomyces cerevisiae mRNA-binding protein Cth2, which belongs to the tristetraprolin family of tandem zinc finger proteins, coordinates a global remodeling of the cellular metabolism by promoting the degradation of multiple mRNAs encoding highly iron-consuming proteins.	Iron	15-19	Tis11p	Saccharomyces cerevisiae S288C	90-94
27795405-5	2016	Specifically, similarly to baker"s yeast, Aft1 is the main positive regulator under iron starvation conditions, while Cth2 degrades mRNAs encoding iron-requiring enzymes.	Iron	147-151	Tis11p	Saccharomyces cerevisiae S288C	118-122
27795405-6	2016	However, unlike the case with S. cerevisiae, a Sef1 ortholog is required for full growth under iron limitation conditions, making C. glabrata an evolutionary intermediate to SEF1-dependent fungal pathogens.	Iron	95-99	Sef1p	Saccharomyces cerevisiae S288C	47-51
27667161-4	2016	This study aimed to explore the use of next-generation sequencing (NGS) technology to analyse a panel of iron metabolism-related genes (HFE, TFR2, HJV, HAMP, SLC40A1, and FTL) in 87 non-classic HH Portuguese patients.	Iron	105-109	transferrin receptor 2	Homo sapiens	141-145
30228242-4	2018	In response to iron scarcity, the conserved Saccharomyces cerevisiae mRNA-binding protein Cth2, which belongs to the tristetraprolin family of tandem zinc finger proteins, coordinates a global remodeling of the cellular metabolism by promoting the degradation of multiple mRNAs encoding highly iron-consuming proteins.	Iron	294-298	Tis11p	Saccharomyces cerevisiae S288C	90-94
27667161-4	2016	This study aimed to explore the use of next-generation sequencing (NGS) technology to analyse a panel of iron metabolism-related genes (HFE, TFR2, HJV, HAMP, SLC40A1, and FTL) in 87 non-classic HH Portuguese patients.	Iron	105-109	hemojuvelin BMP co-receptor	Homo sapiens	147-150
27667161-4	2016	This study aimed to explore the use of next-generation sequencing (NGS) technology to analyse a panel of iron metabolism-related genes (HFE, TFR2, HJV, HAMP, SLC40A1, and FTL) in 87 non-classic HH Portuguese patients.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	152-156
30228242-7	2018	When Cth2 degradation is impaired by either mutagenesis of the Cth2 serine residues or deletion of GRR1, the levels of Cth2 rise and abrogate growth in iron-depleted conditions.	Iron	152-156	Tis11p	Saccharomyces cerevisiae S288C	5-9
27667162-2	2016	In mammals systemic iron homeostasis relies on hepcidin, a peptide hormone with defensin properties, and its target, the cell iron exporter ferroportin.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	47-55
27667162-3	2016	Hepcidin and ferroportin transcription are both upregulated by high iron levels, but are inversely regulated upon inflammation, leading to hypoferremia.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
30228242-7	2018	When Cth2 degradation is impaired by either mutagenesis of the Cth2 serine residues or deletion of GRR1, the levels of Cth2 rise and abrogate growth in iron-depleted conditions.	Iron	152-156	Tis11p	Saccharomyces cerevisiae S288C	63-67
30228242-7	2018	When Cth2 degradation is impaired by either mutagenesis of the Cth2 serine residues or deletion of GRR1, the levels of Cth2 rise and abrogate growth in iron-depleted conditions.	Iron	152-156	Tis11p	Saccharomyces cerevisiae S288C	63-67
30228242-11	2018	Saccharomyces cerevisiae Cth2 is a conserved mRNA-binding protein that coordinates a global reprogramming of iron metabolism in response to iron deficiency in order to optimize its utilization.	Iron	109-113	Tis11p	Saccharomyces cerevisiae S288C	25-29
27538573-0	2016	Iron-sulfur cluster exchange reactions mediated by the human Nfu protein.	Iron	0-4	NFU1 iron-sulfur cluster scaffold	Homo sapiens	61-64
30228242-12	2018	Here we report that the phosphorylation of Cth2 at specific serine residues is essential to regulate the stability of the protein and adaptation to iron depletion.	Iron	148-152	Tis11p	Saccharomyces cerevisiae S288C	43-47
27538573-3	2016	There is less functional conservation between bacterial and human Nfu proteins, particularly concerning their Iron-sulfur cluster binding and transfer roles.	Iron	110-114	NFU1 iron-sulfur cluster scaffold	Homo sapiens	66-69
27538573-5	2016	The mechanism of cluster uptake from a physiologically relevant [2Fe-2S](GS)4 cluster complex, and extraction of the Nfu-bound iron-sulfur cluster by glutathione are described.	Iron	127-131	NFU1 iron-sulfur cluster scaffold	Homo sapiens	117-120
27590019-2	2016	This complex demonstrates physiologically relevant solution chemistry and is a viable substrate for iron-sulfur cluster transport by Atm1p exporter protein.	Iron	100-104	ATP binding cassette subfamily B member 7	Homo sapiens	133-138
30215866-5	2018	Copper in enterocytes may positively influence iron transport, and hepatic copper may enhance biosynthesis of a circulating ferroxidase, ceruloplasmin, which potentiates iron release from stores.	Iron	170-174	ceruloplasmin	Homo sapiens	137-150
26992200-10	2016	CONCLUSION: Preterm infants can control iron levels by regulating hepcidin and decreasing erythropoietin.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	66-74
30215866-6	2018	Moreover, many intestinal genes related to iron absorption are transactivated by a hypoxia-inducible transcription factor, hypoxia-inducible factor-2alpha (HIF2alpha), during iron deficiency.	Iron	43-47	endothelial PAS domain protein 1	Homo sapiens	123-154
30215866-6	2018	Moreover, many intestinal genes related to iron absorption are transactivated by a hypoxia-inducible transcription factor, hypoxia-inducible factor-2alpha (HIF2alpha), during iron deficiency.	Iron	43-47	endothelial PAS domain protein 1	Homo sapiens	156-165
26998752-0	2016	Hepcidin resistance in dysmetabolic iron overload.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
30253856-8	2018	Interestingly, SD showed a stronger IgG1 and particularly IgG2 reactivity with transferrin, an iron-binding protein, than APD and AND.	Iron	95-99	inhibitor of carbonic anhydrase	Canis lupus familiaris	79-90
26998752-10	2016	CONCLUSIONS: Dysmetabolic iron overload syndrome is associated with a subtle impairment in the ability of the iron hormone hepcidin to restrain iron absorption following an iron challenge, suggesting a hepcidin resistance state.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	123-131
26998752-10	2016	CONCLUSIONS: Dysmetabolic iron overload syndrome is associated with a subtle impairment in the ability of the iron hormone hepcidin to restrain iron absorption following an iron challenge, suggesting a hepcidin resistance state.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	202-210
26998752-10	2016	CONCLUSIONS: Dysmetabolic iron overload syndrome is associated with a subtle impairment in the ability of the iron hormone hepcidin to restrain iron absorption following an iron challenge, suggesting a hepcidin resistance state.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	123-131
26998752-10	2016	CONCLUSIONS: Dysmetabolic iron overload syndrome is associated with a subtle impairment in the ability of the iron hormone hepcidin to restrain iron absorption following an iron challenge, suggesting a hepcidin resistance state.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	202-210
26998752-10	2016	CONCLUSIONS: Dysmetabolic iron overload syndrome is associated with a subtle impairment in the ability of the iron hormone hepcidin to restrain iron absorption following an iron challenge, suggesting a hepcidin resistance state.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	123-131
30214812-0	2018	Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
26998752-10	2016	CONCLUSIONS: Dysmetabolic iron overload syndrome is associated with a subtle impairment in the ability of the iron hormone hepcidin to restrain iron absorption following an iron challenge, suggesting a hepcidin resistance state.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	202-210
30214812-2	2018	The aim of this study was to determine whether serum hepcidin concentration, measured early after ICU admission in patients with anaemia, could identify a group in whom intravenous (IV) iron therapy decreased the subsequent RBC transfusion requirement.	Iron	186-190	hepcidin antimicrobial peptide	Homo sapiens	53-61
27107905-1	2016	FANCJ is a superfamily 2 DNA helicase, which also belongs to the iron-sulfur domain containing helicases that include XPD, ChlR1 (DDX11), and RTEL1.	Iron	65-69	BRCA1 interacting helicase 1	Homo sapiens	0-5
27107905-1	2016	FANCJ is a superfamily 2 DNA helicase, which also belongs to the iron-sulfur domain containing helicases that include XPD, ChlR1 (DDX11), and RTEL1.	Iron	65-69	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	118-121
30214812-6	2018	The response to IV iron therapy compared with placebo was assessed according to tertile of hepcidin concentration.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	91-99
30214812-8	2018	For patients in the lower two tertiles of hepcidin concentration (&lt; 53.0 mug), IV iron therapy compared with placebo was associated with a significant decrease in RBC transfusion requirement [risk ratio 0.48 (95% CI 0.26-0.85), p = 0.013].	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	42-50
30214812-9	2018	Conclusions: In critically ill patients with anaemia admitted to an ICU, baseline hepcidin concentration predicts RBC transfusion requirement and is able to identify a group of patients in whom IV iron compared with placebo is associated with a significant decrease in RBC transfusion requirement.	Iron	197-201	hepcidin antimicrobial peptide	Homo sapiens	82-90
29322429-0	2018	Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet".	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	18-26
26142396-7	2016	Animal experiments and clinical studies have also shown that oral iron overload can cause excessive iron accumulation despite high hepcidin levels, which are not able to block iron absorption completely.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	131-139
30463816-1	2018	Studies have shown that Chinese herb caulis extract can effectively inhibit the expression of the core regulatory hormone hepcidin in iron metabolism and significantly increase the iron level in the body.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	122-130
26922566-12	2016	Failure of this proportional suppression of hepcidin indicates poor systemic bioavailability of iron to the mother and poor placental transport.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	44-52
29660878-0	2018	Investigation of the behaviour of zero-valent iron nanoparticles and their interactions with Cd2+ in wastewater by single particle ICP-MS. Zero-valent iron nanoparticles (nZVI) exhibit great potential for the removal of metal contaminants from wastewater.	Iron	46-50	CD2 molecule	Homo sapiens	93-96
27711283-0	2016	Electrocatalytic hydrogen evolution using the MS2@MoS2/rGO (M = Fe or Ni) hybrid catalyst.	Iron	64-66	MS2	Homo sapiens	46-49
27711283-2	2016	The enhanced electrocatalytic activity benefits from the unique synergistic effects of graphene sheets enhancing the conductivity of the hybrid, MS2 (M = Fe or Ni) nanoparticles and MoS2 nanosheets providing abundant electrocatalytically active sites.	Iron	154-156	MS2	Homo sapiens	145-148
27602957-0	2016	The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/beta-catenin signaling in human multiple myeloma.	Iron	4-8	protein tyrosine kinase 2 beta	Homo sapiens	71-75
27602957-0	2016	The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/beta-catenin signaling in human multiple myeloma.	Iron	4-8	catenin beta 1	Homo sapiens	76-88
29660878-0	2018	Investigation of the behaviour of zero-valent iron nanoparticles and their interactions with Cd2+ in wastewater by single particle ICP-MS. Zero-valent iron nanoparticles (nZVI) exhibit great potential for the removal of metal contaminants from wastewater.	Iron	151-155	CD2 molecule	Homo sapiens	93-96
30154413-3	2018	Hepcidin treatment caused increased proliferation of these cells most likely by binding ferroportin resulting in internalisation and cellular iron retention.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	0-8
27262547-9	2016	Surface characterization of FeS by XPS indicated that both Fe(II) and S(-II) on the FeS surface might have contributed considerably to the transformation of HBCD.	Iron	28-31	transcription elongation factor A1	Homo sapiens	70-75
30154413-4	2018	Cellular iron content increased with hepcidin treatment.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	37-45
27353379-0	2016	The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.	Iron	47-51	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	31-35
27353379-3	2016	In this study, we identified the ortholog of LYS4 in the human fungal pathogen, Cryptococcus neoformans, and found that LYS4 expression is regulated by iron levels and by the iron-related transcription factors Hap3 and HapX.	Iron	152-156	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	120-124
30135444-1	2018	TMPRSS6, also known as matriptase-2, is a type II transmembrane serine protease that plays a major role in iron homeostasis by acting as a negative regulator of hepcidin production through cleavage of the BMP co-receptor haemojuvelin.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	161-169
27353379-3	2016	In this study, we identified the ortholog of LYS4 in the human fungal pathogen, Cryptococcus neoformans, and found that LYS4 expression is regulated by iron levels and by the iron-related transcription factors Hap3 and HapX.	Iron	175-179	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	45-49
27353379-3	2016	In this study, we identified the ortholog of LYS4 in the human fungal pathogen, Cryptococcus neoformans, and found that LYS4 expression is regulated by iron levels and by the iron-related transcription factors Hap3 and HapX.	Iron	175-179	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	120-124
27353379-7	2016	We showed that these phenotypes were due in part to impaired mitochondrial function as a result of LYS4 deletion, which we propose disrupts iron homeostasis in the organelle.	Iron	140-144	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	99-103
30135444-1	2018	TMPRSS6, also known as matriptase-2, is a type II transmembrane serine protease that plays a major role in iron homeostasis by acting as a negative regulator of hepcidin production through cleavage of the BMP co-receptor haemojuvelin.	Iron	107-111	bone morphogenetic protein 1	Homo sapiens	205-208
30135444-1	2018	TMPRSS6, also known as matriptase-2, is a type II transmembrane serine protease that plays a major role in iron homeostasis by acting as a negative regulator of hepcidin production through cleavage of the BMP co-receptor haemojuvelin.	Iron	107-111	hemojuvelin BMP co-receptor	Homo sapiens	221-233
30087169-7	2018	The 1649 and 1650 (p19) genes encode an iron transporter and a periplasmic iron binding protein, respectively; however, the role of the downstream 1651-1656 genes was unknown.	Iron	40-44	interleukin 23 subunit alpha	Homo sapiens	19-22
29263898-2	2016	We previously showed that supplementation of the iron-exporter, ceruloplasmin, selectively corrected nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model.	Iron	49-53	ceruloplasmin	Mus musculus	64-77
29263898-2	2016	We previously showed that supplementation of the iron-exporter, ceruloplasmin, selectively corrected nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model.	Iron	108-112	ceruloplasmin	Mus musculus	64-77
29263898-3	2016	Ceruloplasmin delivers iron to transferrin (Tf), the extracellular iron-transporting protein.	Iron	23-27	ceruloplasmin	Mus musculus	0-13
30087169-9	2018	In iron-restricted medium, the 1651-1656 and p19 genes were required for optimal growth when using human fecal extracts as an iron source.	Iron	3-7	interleukin 23 subunit alpha	Homo sapiens	45-48
27519943-2	2016	Because its levels are inappropriately low in patients with iron overload syndromes, hepcidin is a potential drug target.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	85-93
30087169-9	2018	In iron-restricted medium, the 1651-1656 and p19 genes were required for optimal growth when using human fecal extracts as an iron source.	Iron	126-130	interleukin 23 subunit alpha	Homo sapiens	45-48
30010336-2	2018	The unusually large quadrupole splitting (Delta EQ = +2.2 mm s-1) and asymmetric parameter (eta = 0.9) of the five-coordinate heme carbene [Fe(TTP)(CCl2)], which is the largest among all known low spin ferrohemes, has driven investigations by means of Mossbauer effect Nuclear Resonance Vibrational Spectroscopy (NRVS).	Iron	140-142	C-C motif chemokine ligand 2	Homo sapiens	148-152
27585745-4	2016	Hepcidin - the master regulator of iron metabolism that integrates signals of infection and iron deficiency - offers the possibility of new solutions to diagnose and combat global iron deficiency.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
27585745-5	2016	We aim to evaluate a hepcidin-screening-based iron supplementation intervention using hepcidin cut-offs designed to indicate that an individual requires iron, is safe to receive it and will absorb it.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	21-29
27585745-5	2016	We aim to evaluate a hepcidin-screening-based iron supplementation intervention using hepcidin cut-offs designed to indicate that an individual requires iron, is safe to receive it and will absorb it.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	86-94
30072660-1	2018	Hepcidin-25 was identified as the main iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
27585745-5	2016	We aim to evaluate a hepcidin-screening-based iron supplementation intervention using hepcidin cut-offs designed to indicate that an individual requires iron, is safe to receive it and will absorb it.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	21-29
27585745-5	2016	We aim to evaluate a hepcidin-screening-based iron supplementation intervention using hepcidin cut-offs designed to indicate that an individual requires iron, is safe to receive it and will absorb it.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	86-94
27585745-11	2016	DISCUSSION: A screen-and-treat approach using hepcidin has the potential to make iron administration safer in areas with widespread infections.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	46-54
30072660-1	2018	Hepcidin-25 was identified as the main iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	0-8
30010796-14	2018	This study describes a novel complex neurological phenotype with unusual MRI and muscle biopsy features, conclusively mapped to a mutation in FDX2, which encodes a ubiquitously expressed mitochondrial ferredoxin essential for early [Fe-S] cluster biogenesis.	Iron	233-237	ferredoxin 2	Homo sapiens	142-146
27438893-8	2016	In univariate analysis, plasma PCSK9 showed a significant positive correlation with serum total iron binding capacity, vitamin E, plasma renin and phosphaturia, and there was a trend towards a positive correlation with total serum cholesterol.	Iron	96-100	proprotein convertase subtilisin/kexin type 9	Homo sapiens	31-36
27528230-2	2016	This gene codifies a protein with ubiquitin ligase activity that regulates the activity of tumor protein p53 and is involved in important cellular processes such as DNA repair, cell cycle, cancer, and iron metabolism.	Iron	201-205	transformation related protein 53, pseudogene	Mus musculus	105-108
29989329-0	2018	Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway.	Iron	0-4	transformation related protein 53, pseudogene	Mus musculus	85-88
27297105-9	2016	The redox inactive form was observed to have no effect on the lyase reaction, while reactions with the normal heme-iron containing cyt b5 were enhanced ~5 fold as compared to reactions in the absence of cyt b5.	Iron	115-119	cytochrome b5 type A	Homo sapiens	131-137
27532773-0	2016	Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients.	Iron	25-29	bolA family member 3	Homo sapiens	17-21
29989329-9	2018	RESULTS: Iron overload induced M1 polarization by increasing ROS production and inducing p53 acetylation in RAW cells, and reduction in ROS levels by NAC repressed M1 polarization and p53 acetylation.	Iron	9-13	transformation related protein 53, pseudogene	Mus musculus	89-92
27532773-5	2016	Additional studies focused on the mitochondrial BolA proteins, Bol1 and Bol3 (yeast homolog to human BOLA3), revealing that Bol1 functions earlier in Fe-S biogenesis with the monothiol glutaredoxin, Grx5, and Bol3 functions late with Nfu1.	Iron	150-154	bolA family member 3	Homo sapiens	72-76
29989329-11	2018	These results showed that high ROS levels induced by iron overload polarized macrophages to the M1 subtype by enhancing p300/CBP acetyltransferase activity and promoting p53 acetylation.	Iron	53-57	transformation related protein 53, pseudogene	Mus musculus	170-173
27532773-5	2016	Additional studies focused on the mitochondrial BolA proteins, Bol1 and Bol3 (yeast homolog to human BOLA3), revealing that Bol1 functions earlier in Fe-S biogenesis with the monothiol glutaredoxin, Grx5, and Bol3 functions late with Nfu1.	Iron	150-154	bolA family member 3	Homo sapiens	101-106
27532773-6	2016	Given these observations, we propose that Nfu1, assisted by Bol3, functions to facilitate Fe-S transfer from the biosynthetic apparatus to the client proteins preventing oxidative damage to [4Fe-4S] clusters.	Iron	90-94	bolA family member 3	Homo sapiens	60-64
29698685-3	2018	In mammalian cells, the accumulation of heme oxygenase-1 (HO-1), which catalyzes the breakdown of heme into CO, free iron and biliverdin, was reported to protect cells against potentially lethal concentrations of CdCl2.	Iron	117-121	heme oxygenase 1	Homo sapiens	40-56
27532424-7	2016	Lipid metabolism was the main pathway observed in the analysis of metabolic and canonical signaling pathways for the genes identified as DE, including the genes FASN, FABP4, and THRSP, which are functional candidates for beef quality, suggesting reduced lipogenic activities with lower iron content.	Iron	286-290	fatty acid synthase	Bos taurus	161-165
27264950-1	2016	Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorption and reticuloendothelial sequestration of iron by interacting with ferroportin.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
29698685-3	2018	In mammalian cells, the accumulation of heme oxygenase-1 (HO-1), which catalyzes the breakdown of heme into CO, free iron and biliverdin, was reported to protect cells against potentially lethal concentrations of CdCl2.	Iron	117-121	heme oxygenase 1	Homo sapiens	58-62
29635117-3	2018	The resultant label-free immunosensor exhibited the improved performance for highly sensitive detection of PSA based on the enhanced catalytic currents of K3[Fe(CN)6] as a signal probe.	Iron	158-160	kallikrein related peptidase 3	Homo sapiens	107-110
27237585-4	2016	All these dioxygenases, ALKBH1-8 and FTO, contain a conserved alpha-ketoglutarate/iron-dependent domain for methyl modifications and de-modifications.	Iron	82-86	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	24-40
29878770-0	2018	Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2.	Iron	125-129	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	44-64
27117373-13	2016	CONCLUSION(S): Divalent metal transporter-1 overexpression in endometriosis patients" endometrium can increase iron influx to endometrial cells, inducing oxidative stress-mediated proinflammatory signaling.	Iron	111-115	solute carrier family 11 member 2	Homo sapiens	15-43
27343690-0	2016	Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson"s disease.	Iron	34-38	synuclein, alpha	Mus musculus	0-15
29878770-0	2018	Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2.	Iron	125-129	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	66-73
27343690-0	2016	Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson"s disease.	Iron	99-103	synuclein, alpha	Mus musculus	0-15
29878770-0	2018	Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2.	Iron	125-129	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	139-146
27343690-2	2016	Here, we demonstrate that alpha-syn, the principal protein involved in the pathogenesis of PD, is expressed widely in the neuroretina, and facilitates the uptake of transferrin-bound iron (Tf-Fe) by retinal pigment epithelial (RPE) cells that form the outer blood-retinal barrier.	Iron	183-187	synuclein, alpha	Mus musculus	26-35
27343690-3	2016	Absence of alpha-syn in knock-out mice (alpha-syn(-/-)) resulted in down-regulation of ferritin in the neuroretina, indicating depletion of cellular iron stores.	Iron	149-153	synuclein, alpha	Mus musculus	11-20
29878770-2	2018	Previous studies have reported a number of CYP11B2 inhibitors, most of which have an imidazole or pyridine ring to coordinate the heme-iron motif of CYP11B2; however, highly selective inhibitors of human CYP11B2 are still needed.	Iron	135-139	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	43-50
27343690-9	2016	Interestingly, exposure to exogenous iron increased membrane association and co-localization of alpha-syn with TfR, supporting its role in iron uptake by the Tf/TfR complex.	Iron	37-41	synuclein alpha	Homo sapiens	96-105
27343690-9	2016	Interestingly, exposure to exogenous iron increased membrane association and co-localization of alpha-syn with TfR, supporting its role in iron uptake by the Tf/TfR complex.	Iron	139-143	synuclein alpha	Homo sapiens	96-105
29878770-2	2018	Previous studies have reported a number of CYP11B2 inhibitors, most of which have an imidazole or pyridine ring to coordinate the heme-iron motif of CYP11B2; however, highly selective inhibitors of human CYP11B2 are still needed.	Iron	135-139	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	149-156
29878770-2	2018	Previous studies have reported a number of CYP11B2 inhibitors, most of which have an imidazole or pyridine ring to coordinate the heme-iron motif of CYP11B2; however, highly selective inhibitors of human CYP11B2 are still needed.	Iron	135-139	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	149-156
30002810-9	2018	Conclusion: We conclude that mutant huntingtin may cause abnormal iron homeostatic pathways by increasing IRP1 expression in Huntington"s disease, suggesting potential therapeutic target.	Iron	66-70	huntingtin	Mus musculus	36-46
27031690-2	2016	Iron hormone, hepcidin, plays a critical role in iron homeostasis through interaction with ferroportin (FPN), a major cellular iron exporter.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	14-22
27031690-2	2016	Iron hormone, hepcidin, plays a critical role in iron homeostasis through interaction with ferroportin (FPN), a major cellular iron exporter.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	14-22
27031690-2	2016	Iron hormone, hepcidin, plays a critical role in iron homeostasis through interaction with ferroportin (FPN), a major cellular iron exporter.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	14-22
27206843-8	2016	Overall, our data support a model of neurotoxicity where Pb enhances iron regulatory protein/IRE-mediated repression of APP and FTH translation.	Iron	69-73	ferritin heavy chain 1	Homo sapiens	128-131
30057485-0	2018	Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	6-14
26758041-1	2016	Iron overload and transfusion dependance portend poor risk in myelodysplastic syndromes (MDS); bone marrow macrophages store iron and limit oxidative damage through heme oxygenase-1 (HO1).	Iron	0-4	heme oxygenase 1	Homo sapiens	183-186
26758041-1	2016	Iron overload and transfusion dependance portend poor risk in myelodysplastic syndromes (MDS); bone marrow macrophages store iron and limit oxidative damage through heme oxygenase-1 (HO1).	Iron	125-129	heme oxygenase 1	Homo sapiens	183-186
30057485-9	2018	These findings support the serum hepcidin level as useful in assessing iron status in children with cystic fibrosis.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	33-41
29452096-1	2018	Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO, plays a critical role in inflammation and iron homeostasis.	Iron	120-124	heme oxygenase 1	Homo sapiens	0-21
27146013-1	2016	Hepcidin is the master regulator of systemic iron homeostasis, facilitating iron balance by controlling intestinal iron absorption and recycling.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
27146013-1	2016	Hepcidin is the master regulator of systemic iron homeostasis, facilitating iron balance by controlling intestinal iron absorption and recycling.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
27146013-1	2016	Hepcidin is the master regulator of systemic iron homeostasis, facilitating iron balance by controlling intestinal iron absorption and recycling.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
30079314-7	2018	PSA, a biomarker of prostate cancer, was significantly and positively correlated with the intake of animal iron and cholesterol in men.	Iron	107-111	kallikrein related peptidase 3	Homo sapiens	0-3
27146013-2	2016	Hepcidin levels are suppressed when erythropoiesis is stimulated, for example following acute blood loss, appropriately enhancing cellular iron export to the plasma to support production of new red blood cells.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	0-8
27146013-4	2016	The ligands, receptors, and canonical pathways by which iron loading and inflammation upregulate hepcidin expression have been largely established.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	97-105
28945281-0	2018	In vivo study of the effect of lactoferrin on iron metabolism and bioavailability from different iron chemical species for formula milk fortification.	Iron	46-50	lactotransferrin	Rattus norvegicus	31-42
26790966-9	2016	Of the four missense variants, p.L263F, p.L474P, and p.R848H localize to regions between the helicase motifs, while p.L340F resides in an iron-sulfur domain of BRIP1.	Iron	138-142	BRCA1 interacting helicase 1	Homo sapiens	160-165
28945281-0	2018	In vivo study of the effect of lactoferrin on iron metabolism and bioavailability from different iron chemical species for formula milk fortification.	Iron	97-101	lactotransferrin	Rattus norvegicus	31-42
29396964-10	2018	These findings suggest that elevated levels of estrogen reduce hepcidin synthesis as means of enhancing serum iron content in menstruating women.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	63-71
27137899-3	2016	RECENT FINDINGS: The iron-regulatory hormone hepcidin and its target, the iron exporter ferroportin (FPN), play central roles in iron homeostasis.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	45-53
27345021-8	2016	The NLRP3 inflammasome senses chemically diverse PAMPs and damage associated molecular patterns (DAMPs), including extracellular ATP and iron-containing heme.	Iron	137-141	NLR family, pyrin domain containing 3	Mus musculus	4-9
29695834-1	2018	Hepcidin is a peptide hormone that negatively regulates iron efflux and plays an important role in controlling the growth of breast tumors.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
27376332-0	2016	Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.	Iron	35-40	BRCA1 interacting helicase 1	Homo sapiens	29-34
29695834-9	2018	The increase in hepcidin as breast cells develop a three-dimensional architecture increases intracellular iron, as indicated by an increase in the iron storage protein ferritin.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	16-24
27261274-5	2016	Over the last 20 years, identification of transmembrane iron transporters and the iron regulatory hormone hepcidin has greatly expanded the knowledge of cellular iron transport and its regulation by systemic iron status.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	106-114
29695834-9	2018	The increase in hepcidin as breast cells develop a three-dimensional architecture increases intracellular iron, as indicated by an increase in the iron storage protein ferritin.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	16-24
29695834-15	2018	Collectively, our results suggest a new paradigm for tumor-mediated control of iron through the control of hepcidin by tumor architecture and the breast tumor microenvironment.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	107-115
29784767-4	2018	Even though sufficient Fe was supplied, the Fe-responsive transcription factors bHLH38, 39, 100, and 101 and their downstream targets FRO2 and IRT1 mediating Fe uptake were strongly upregulated in the nramp3 nramp4 mutant.	Iron	44-46	allograft inflammatory factor 1	Homo sapiens	143-147
27498743-7	2016	In the liver, TFR2 forms a complex with HFE, a hereditary hemochromatosis-associated protein, and acts as an iron sensor.	Iron	109-113	transferrin receptor 2	Homo sapiens	14-18
29784767-4	2018	Even though sufficient Fe was supplied, the Fe-responsive transcription factors bHLH38, 39, 100, and 101 and their downstream targets FRO2 and IRT1 mediating Fe uptake were strongly upregulated in the nramp3 nramp4 mutant.	Iron	44-46	allograft inflammatory factor 1	Homo sapiens	143-147
27409114-4	2016	But the iron powders of MRF fluid are easily embedded into the soft surface of KDP crystal, which will greatly decrease the laser-induced damage resistance.	Iron	8-12	myelin regulatory factor	Homo sapiens	24-27
29883959-0	2018	Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.	Iron	108-112	ceruloplasmin	Mus musculus	0-13
29958400-0	2018	Prognostic Value of Iron-Homeostasis Regulating Peptide Hepcidin in Coronary Heart Disease-Evidence from the Large AtheroGene Study.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	56-64
27072365-5	2016	Expression of this mutant Hjv in the liver of Hjv(-/-) mice dramatically attenuated its induction of BMP signaling and hepcidin mRNA, suggesting that interaction with neogenin is critical for the iron regulatory function of HJV.	Iron	196-200	neogenin	Mus musculus	167-175
29958400-2	2018	The liver-derived peptide hepcidin has been recognized as a key regulator of iron homeostasis.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	26-34
29872820-6	2018	Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin.	Iron	43-47	interferon alpha inducible protein 27	Homo sapiens	83-86
26592557-7	2016	CONCLUSION: The findings suggest that pediatric patients with erythrocyte membrane defects and thalassemia traits are more susceptible to iron overload than the general population and that the (hepcidin/ferritin)/sTfR ratio can be used to monitor any worsening of the disease.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	194-202
26850692-7	2016	Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway.	Iron	0-4	interferon alpha inducible protein 27	Homo sapiens	157-160
29872820-6	2018	Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin.	Iron	43-47	H3 histone pseudogene 16	Homo sapiens	87-90
26850692-7	2016	Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway.	Iron	0-4	cyclin dependent kinase inhibitor 1B	Homo sapiens	161-165
29871592-0	2018	Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
27106490-4	2016	New insights into iron homeostasis lead to new diagnostic assays such as serum hepcidin, serum transferrin receptor and reticulocyte hemoglobin equivalent.Importance of proper diagnosis and treatment for this population is large since there is a correlation between anemia and morbidity - mortality.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	79-87
29871592-2	2018	Altered production of the iron-regulatory peptide hepcidin has been reported in NAFLD, but it is unclear if this is related to iron accumulation, lipid status or steatohepatitis.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	50-58
29871592-7	2018	RESULTS: Serum hepcidin was increased similarly in NAFLD with DIOS as in the other chronic liver diseases with iron overload, except for genetic hemochromatosis.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	15-23
27496436-1	2016	BACKGROUND: Hepcidin is a peptide hormone that regulates iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	12-20
29871592-8	2018	HAMP mRNA in liver tissue, and serum hepcidin, both correlated to liver iron content in NAFLD patients (r2 = 0.45, p &lt; 0.05 and r2 = 0.27, p &lt; 0.05 respectively) but not to body mass index, NAFLD activity score or serum lipids.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-4
29871592-8	2018	HAMP mRNA in liver tissue, and serum hepcidin, both correlated to liver iron content in NAFLD patients (r2 = 0.45, p &lt; 0.05 and r2 = 0.27, p &lt; 0.05 respectively) but not to body mass index, NAFLD activity score or serum lipids.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	37-45
29871592-10	2018	CONCLUSIONS: In NAFLD with or without dysmetabolic iron overload, serum hepcidin and HAMP mRNA in liver correlate to body iron content but not to the degree of steatohepatitis or lipid status.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	72-80
29871592-10	2018	CONCLUSIONS: In NAFLD with or without dysmetabolic iron overload, serum hepcidin and HAMP mRNA in liver correlate to body iron content but not to the degree of steatohepatitis or lipid status.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	85-89
29733522-10	2018	CONCLUSIONS: Ceruloplasmin interference in iron metabolism was closely related with PD development.	Iron	43-47	ceruloplasmin	Homo sapiens	13-26
27243905-1	2016	The iron-sulfur cluster containing protein mitoNEET is known to modulate the oxidative capacity of cardiac mitochondria but its function during myocardial reperfusion injury after transient ischemia is unknown.	Iron	4-8	CDGSH iron sulfur domain 1	Homo sapiens	43-51
27139025-2	2016	Both the vapA and rhbC genes are up-regulated in an iron (Fe)-deprived environment, such as that found within macrophages.	Iron	52-56	virulence-associated 15-17 kDa antigen	Rhodococcus equi	9-13
29704621-1	2018	Increasing evidence suggests that the mitochondrial outer membrane protein mitoNEET is a key regulator of energy metabolism, iron homeostasis, and production of reactive oxygen species in mitochondria.	Iron	125-129	CDGSH iron sulfur domain 1	Homo sapiens	75-83
27139025-2	2016	Both the vapA and rhbC genes are up-regulated in an iron (Fe)-deprived environment, such as that found within macrophages.	Iron	58-60	virulence-associated 15-17 kDa antigen	Rhodococcus equi	9-13
29660664-1	2018	Hepcidin-25 peptide is a biomarker which is known to have considerable clinical potential for diagnosing iron-related diseases.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
27198537-2	2016	After ICH, overproduction of iron associated with induction of heme oxygenase-1 (HO-1) in brain was observed.	Iron	29-33	heme oxygenase 1	Homo sapiens	63-79
27198537-2	2016	After ICH, overproduction of iron associated with induction of heme oxygenase-1 (HO-1) in brain was observed.	Iron	29-33	heme oxygenase 1	Homo sapiens	81-85
29576242-8	2018	However, upon the addition of both l-cysteine and a reductant (either reduced FDX2 or DTT), Fe2+ is released from FXN as consistent with Fe2+-FXN being the proximal source of iron for Fe-S cluster assembly.	Iron	175-179	ferredoxin 2	Homo sapiens	78-82
27198537-11	2016	These findings open up the prospect for male-specific neuroprotection targeting HO-1 suppression for patients suffering from striatal iron overload.	Iron	134-138	heme oxygenase 1	Homo sapiens	80-84
29576242-8	2018	However, upon the addition of both l-cysteine and a reductant (either reduced FDX2 or DTT), Fe2+ is released from FXN as consistent with Fe2+-FXN being the proximal source of iron for Fe-S cluster assembly.	Iron	92-94	ferredoxin 2	Homo sapiens	78-82
29459227-0	2018	Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	47-55
32262965-10	2016	Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions.	Iron	26-28	secreted phosphoprotein 1	Homo sapiens	141-144
29459227-1	2018	The exact regulation of the liver-secreted peptide hepcidin, the key regulator of systemic iron homeostasis, is still poorly understood.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	51-59
27161430-6	2016	Hepcidin plays an indirect role in erythropoiesis by controlling plasma iron.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
29795546-3	2018	GPX4 normally removes the dangerous products of iron-dependent lipid peroxidation, protecting cell membranes from this type of damage; when GPX4 fails, ferroptosis ensues.	Iron	48-52	glutathione peroxidase 4	Homo sapiens	0-4
27161430-7	2016	Inappropriately high hepcidin levels characterize the rare genetic iron-refractory iron-deficiency anemia (IRIDA) and the common anemia of chronic disease.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	21-29
27161430-10	2016	RESULTS: Erythropoiesis controls iron homeostasis, by releasing erythroferrone that inhibits hepcidin transcription to increase iron acquisition in iron deficiency, hypoxia and EPO treatment.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	93-101
27161430-12	2016	Erythroblasts sense circulating iron through the second transferrin receptor (TFR2) that, in animal models, modulates the sensitivity of the erythroid cells to EPO.	Iron	32-36	transferrin receptor 2	Homo sapiens	78-82
26733407-1	2016	BACKGROUND AND AIMS: We sought to correlate hepcidin levels in inflammatory bowel disease [IBD] children with disease activity, inflammatory markers, and iron load test [ILT] and to compare IBD patients with coeliac and healthy patients.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	44-52
26733407-8	2016	Patients with iron malabsorption [IM] showed higher values of ESR, CRP, and hepcidin [p = 0.02, p = 0.001, and p = 0.06, respectively].	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	76-84
29764842-0	2018	Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	12-20
27240811-2	2016	This syndrome belongs to a heterogeneous group of inherited neurodegenerative disorders characterized iron accumulation in the brain, and it is caused by mutations of the C2orf37 gene.	Iron	102-106	DDB1 and CUL4 associated factor 17	Homo sapiens	171-178
29764842-3	2018	Hepcidin is the master regulator of iron homeostasis in vertebrates, responsible for diminishing iron export from macrophages during iron overload or infection.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
29764842-3	2018	Hepcidin is the master regulator of iron homeostasis in vertebrates, responsible for diminishing iron export from macrophages during iron overload or infection.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
26970931-11	2016	Although maternal BMI negatively impacted fetal iron status, hepcidin, related to obesity in adults, was related to iron status and not obesity in fetuses.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	61-69
29764842-3	2018	Hepcidin is the master regulator of iron homeostasis in vertebrates, responsible for diminishing iron export from macrophages during iron overload or infection.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
29783634-4	2018	Molecular modeling studies confirmed a consolidated binding mode in which the nitrogen of the imidazolyl moiety coordinated the heme ferrous iron, meanwhile the hydrophobic groups were located in the western region of HO-1 binding pocket.	Iron	141-145	heme oxygenase 1	Homo sapiens	218-222
29771935-8	2018	The increase of intracellular iron also reduced LPS-induced hepcidin gene expression and abolished ferroportin down-regulation in macrophages, in line with macrophage polarization.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	60-68
27109647-4	2016	RESULTS Ceruloplasmin plays an essential role in iron metabolism and inactivating free radicals.	Iron	49-53	ceruloplasmin	Homo sapiens	8-21
29771984-1	2018	Production of the iron regulatory peptide hepcidin is tightly controlled by a network of proteins in hepatocytes that sense levels of iron in the circulation (as diferric-transferrin) and in tissues (in ferritin).	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	42-50
29771984-1	2018	Production of the iron regulatory peptide hepcidin is tightly controlled by a network of proteins in hepatocytes that sense levels of iron in the circulation (as diferric-transferrin) and in tissues (in ferritin).	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	42-50
29771984-10	2018	However, HAMP mRNA expression in Huh7 was increased by AZA treatment, suggesting that methylation of one or more iron sensing genes may indirectly influence HAMP expression.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	9-13
26769358-4	2016	Recent studies showed that mutant and wild-type alpha-synuclein may have differential interaction with iron and mutant alpha-synuclein toxicity could be preferentially exacerbated by iron.	Iron	103-107	synuclein alpha	Homo sapiens	48-63
26769358-4	2016	Recent studies showed that mutant and wild-type alpha-synuclein may have differential interaction with iron and mutant alpha-synuclein toxicity could be preferentially exacerbated by iron.	Iron	183-187	synuclein alpha	Homo sapiens	48-63
29771984-10	2018	However, HAMP mRNA expression in Huh7 was increased by AZA treatment, suggesting that methylation of one or more iron sensing genes may indirectly influence HAMP expression.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	157-161
26769358-5	2016	We hence hypothesized that iron overload could selectively influence mutant alpha-synuclein toxicity and disease phenotypes.	Iron	27-31	synuclein alpha	Homo sapiens	76-91
26769358-7	2016	We showed that iron treatment induced similar reduction of survival rate in all flies but induced a more severe motor decline in A53T and A30P mutant alpha-synuclein expressing flies, suggesting interaction between mutant alpha-synuclein and iron.	Iron	15-19	synuclein alpha	Homo sapiens	150-165
29771984-11	2018	Our study provides evidence that DNA methylation might control expression of HAMP and other hepatic iron sensing genes, and indicates that epigenetic influences on iron homeostasis warrant further investigation.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	77-81
26769358-7	2016	We showed that iron treatment induced similar reduction of survival rate in all flies but induced a more severe motor decline in A53T and A30P mutant alpha-synuclein expressing flies, suggesting interaction between mutant alpha-synuclein and iron.	Iron	15-19	synuclein alpha	Homo sapiens	222-237
29771984-11	2018	Our study provides evidence that DNA methylation might control expression of HAMP and other hepatic iron sensing genes, and indicates that epigenetic influences on iron homeostasis warrant further investigation.	Iron	164-168	hepcidin antimicrobial peptide	Homo sapiens	77-81
26769358-8	2016	Although no significant difference in total head iron content was found among these flies, we demonstrated that iron treatment induced selective DA neuron loss in motor-related PPM3 cluster only in the flies that express A53T and A30P mutant alpha-synuclein.	Iron	112-116	synuclein alpha	Homo sapiens	242-257
26769358-9	2016	We provided the first in vivo evidence that iron overload could induce distinctive neuropathology and disease phenotypes in mutant but not WT alpha-synuclein expressing flies, providing insights to the cause of clinical features selectively exhibited by mutant alpha-synuclein carriers.	Iron	44-48	synuclein alpha	Homo sapiens	261-276
29373036-9	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated heart and liver injury, suggesting that Timp3 is a key protective molecule against iron-mediated pathology.	Iron	45-49	tissue inhibitor of metalloproteinase 3	Mus musculus	8-13
29373036-0	2018	TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.	Iron	29-33	tissue inhibitor of metalloproteinase 3	Mus musculus	0-5
29373036-2	2018	We investigated the role of tissue inhibitor of metalloproteinase 3 (TIMP3) in iron overload-mediated tissue injury by subjecting male mice lacking Timp3 ( Timp3-/-) and wild-type (WT) mice to 12 wk of chronic iron overload.	Iron	79-83	tissue inhibitor of metalloproteinase 3	Mus musculus	69-74
26762582-1	2016	The cell-surface serine protease matriptase-2 is a critical stimulator of iron absorption by negatively regulating hepcidin, the key hormone of iron homeostasis.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	115-123
26762582-1	2016	The cell-surface serine protease matriptase-2 is a critical stimulator of iron absorption by negatively regulating hepcidin, the key hormone of iron homeostasis.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	115-123
29113455-0	2018	HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-Overload Murine Models.	Iron	14-18	histone deacetylase 1	Mus musculus	0-5
26677772-5	2016	RESULTS: Gene expression of hepcidin (HAMP) was significantly increased in the SCAT and VAT of obese patients, while transferrin receptor (TFRC) expression was reduced, compared with non-obese controls, suggesting a higher iron load in obese patients.	Iron	223-227	hepcidin antimicrobial peptide	Homo sapiens	28-36
26677772-5	2016	RESULTS: Gene expression of hepcidin (HAMP) was significantly increased in the SCAT and VAT of obese patients, while transferrin receptor (TFRC) expression was reduced, compared with non-obese controls, suggesting a higher iron load in obese patients.	Iron	223-227	hepcidin antimicrobial peptide	Homo sapiens	38-42
26887944-0	2016	Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster.	Iron	27-31	CDGSH iron sulfur domain 1	Homo sapiens	54-62
29113455-0	2018	HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-Overload Murine Models.	Iron	71-75	histone deacetylase 1	Mus musculus	0-5
26887944-0	2016	Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster.	Iron	80-84	CDGSH iron sulfur domain 1	Homo sapiens	54-62
29451472-3	2018	MATERIALS AND METHODS: This case-control study aimed to study the levels of hepcidin and other proinflammatory markers (IL-6, TNF-alpha, hs-CRP) and their relation with anemia in iron- and erythropoietin-naive, non-dialysis CKD (stage 3 - 5) patients.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	76-84
26805965-3	2016	Here we compared the therapeutic effects of oral delivery of bovine milk-derived iron-saturated lactoferrin (Fe-bLF), angiogenin, osteopontin (OPN), colostrum whey protein, Modulen IBD (Nestle Healthsciences, Rhodes, Australia), and cis-9,trans-11 conjugated linoleic acid (CLA)-enriched milk fat in a mouse model of dextran sulfate-induced colitis.	Iron	81-85	lactotransferrin	Bos taurus	96-107
29451472-6	2018	The baseline iron status was then correlated with the serum hepcidin levels.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	60-68
29451472-10	2018	Serum hepcidin levels were highest in those with impaired iron trafficking, followed by those with no iron deficiency, followed by those with absolute iron deficiency (55.16 vs. 49 vs. 11.8, p = 0.005).	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	6-14
29451472-12	2018	CONCLUSION: A positive correlation between hepcidin and other inflammatory biomarkers in non-dialyzed, iron- and EPO-naive pediatric CKD patients suggests a role of these markers in higher hepcidin production and its contribution to iron-restricted erythropoiesis across the spectrum of CKD.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	43-51
29451472-12	2018	CONCLUSION: A positive correlation between hepcidin and other inflammatory biomarkers in non-dialyzed, iron- and EPO-naive pediatric CKD patients suggests a role of these markers in higher hepcidin production and its contribution to iron-restricted erythropoiesis across the spectrum of CKD.	Iron	233-237	hepcidin antimicrobial peptide	Homo sapiens	43-51
27057839-10	2016	Relative to the current conventional therapies, such as phlebotomy and blood transfusion, therapeutics targeting hepcidin would open a new avenue for treatment of iron-related diseases.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	113-121
29451472-13	2018	Median hepcidin levels were highest in those with impaired iron trafficking, followed by those with no iron deficiency, followed by those with absolute iron deficiency, suggesting that in an iron-replete state, high hepcidin levels inhibit iron absorption from the gut and release from iron storing cells, thus restricting erythropoiesis leading to anemia.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	7-15
29604179-5	2018	We suggest that the activation of FET3 by Ace1 prevents the hyper activation of Aft1, possibly by assuring the adequate functioning of mitochondrial iron-sulfur cluster biogenesis.	Iron	149-153	Cup2p	Saccharomyces cerevisiae S288C	42-46
29604179-6	2018	While reinforcing the link between iron and copper homeostasis, this work unveils a novel protection mechanism against copper toxicity mediated by Ace1, which relies in the activation of FET3 and results in the restriction of Aft1 activity as a means to prevent excessive copper accumulation.	Iron	35-39	Cup2p	Saccharomyces cerevisiae S288C	147-151
25833099-2	2016	Metal to protein binding assays have shown that alpha-synuclein can bind iron in vitro; therefore, we hypothesized that iron content and iron distribution could be modified in cellulo, in cells over-expressing alpha-synuclein.	Iron	73-77	synuclein alpha	Homo sapiens	210-225
25833099-2	2016	Metal to protein binding assays have shown that alpha-synuclein can bind iron in vitro; therefore, we hypothesized that iron content and iron distribution could be modified in cellulo, in cells over-expressing alpha-synuclein.	Iron	120-124	synuclein alpha	Homo sapiens	48-63
29452354-1	2018	We probed the role of alpha-synuclein (alpha-syn) in modulating sorting nexin 3 (Snx3)-retromer-mediated recycling of iron transporters in Saccharomyces cerevisiae and Caenorhabditis elegans.	Iron	118-122	synuclein alpha	Homo sapiens	22-31
25833099-2	2016	Metal to protein binding assays have shown that alpha-synuclein can bind iron in vitro; therefore, we hypothesized that iron content and iron distribution could be modified in cellulo, in cells over-expressing alpha-synuclein.	Iron	120-124	synuclein alpha	Homo sapiens	210-225
25833099-2	2016	Metal to protein binding assays have shown that alpha-synuclein can bind iron in vitro; therefore, we hypothesized that iron content and iron distribution could be modified in cellulo, in cells over-expressing alpha-synuclein.	Iron	120-124	synuclein alpha	Homo sapiens	48-63
29452354-5	2018	We discovered that alpha-syn expression phenocopies the high iron condition: under the low iron condition (<1 microM), alpha-syn inhibits Snx3-retromer-mediated recycling of Fet3/Ftr1 and instead shunts Fet3/Ftr1 into the multivesicular body pathway to the vacuole.	Iron	61-65	synuclein alpha	Homo sapiens	19-28
25833099-2	2016	Metal to protein binding assays have shown that alpha-synuclein can bind iron in vitro; therefore, we hypothesized that iron content and iron distribution could be modified in cellulo, in cells over-expressing alpha-synuclein.	Iron	120-124	synuclein alpha	Homo sapiens	210-225
25833099-4	2016	We show that, in neurons exposed to excess iron, the mere over-expression of human alpha-synuclein results in increased levels of intracellular iron and in iron redistribution from the cytoplasm to the perinuclear region within alpha-synuclein-rich inclusions.	Iron	43-47	synuclein alpha	Homo sapiens	83-98
29452354-5	2018	We discovered that alpha-syn expression phenocopies the high iron condition: under the low iron condition (<1 microM), alpha-syn inhibits Snx3-retromer-mediated recycling of Fet3/Ftr1 and instead shunts Fet3/Ftr1 into the multivesicular body pathway to the vacuole.	Iron	61-65	synuclein alpha	Homo sapiens	119-128
25833099-4	2016	We show that, in neurons exposed to excess iron, the mere over-expression of human alpha-synuclein results in increased levels of intracellular iron and in iron redistribution from the cytoplasm to the perinuclear region within alpha-synuclein-rich inclusions.	Iron	43-47	synuclein alpha	Homo sapiens	228-243
25833099-4	2016	We show that, in neurons exposed to excess iron, the mere over-expression of human alpha-synuclein results in increased levels of intracellular iron and in iron redistribution from the cytoplasm to the perinuclear region within alpha-synuclein-rich inclusions.	Iron	144-148	synuclein alpha	Homo sapiens	83-98
25833099-4	2016	We show that, in neurons exposed to excess iron, the mere over-expression of human alpha-synuclein results in increased levels of intracellular iron and in iron redistribution from the cytoplasm to the perinuclear region within alpha-synuclein-rich inclusions.	Iron	144-148	synuclein alpha	Homo sapiens	83-98
29436580-9	2018	Desmin was upregulated in cells subjected to both iron depletion and iron excess in normoxia and hypoxia (all P&lt;0.05), but the greatest augmentation of mRNA expression occurred when iron depletion was combined with hypoxia.	Iron	50-54	desmin	Homo sapiens	0-6
26915800-2	2016	The hepcidin secreted by liver plays an essential role in orchestrating iron metabolism.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	4-12
26915800-3	2016	Lowering iron load in thalassemia patients by means of increasing hepcidin might be a therapeutic strategy.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	66-74
29436580-9	2018	Desmin was upregulated in cells subjected to both iron depletion and iron excess in normoxia and hypoxia (all P&lt;0.05), but the greatest augmentation of mRNA expression occurred when iron depletion was combined with hypoxia.	Iron	69-73	desmin	Homo sapiens	0-6
29436580-9	2018	Desmin was upregulated in cells subjected to both iron depletion and iron excess in normoxia and hypoxia (all P&lt;0.05), but the greatest augmentation of mRNA expression occurred when iron depletion was combined with hypoxia.	Iron	69-73	desmin	Homo sapiens	0-6
29523504-1	2018	Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, beta-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
27019793-6	2016	New regulatory molecules of iron metabolism such as endogenous and dietary chelating molecules, hepcidin, mitochondrial ferritin and their role in health and disease is under evaluation.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	96-104
27019793-6	2016	New regulatory molecules of iron metabolism such as endogenous and dietary chelating molecules, hepcidin, mitochondrial ferritin and their role in health and disease is under evaluation.	Iron	28-32	ferritin mitochondrial	Homo sapiens	106-128
29523504-1	2018	Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, beta-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	0-8
26999096-7	2016	Meanwhile, proteomics data revealed protein level of TLR2 and IL6ST significantly increased 7 times and 2.9 times, respectively, in iron overloaded HH4 cells.	Iron	132-136	interleukin 6 cytokine family signal transducer	Homo sapiens	62-67
29523504-1	2018	Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, beta-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	0-8
29523504-2	2018	Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	0-8
29608844-0	2018	Iron Redox Chemistry Promotes Antiparallel Oligomerization of alpha-Synuclein.	Iron	0-4	synuclein alpha	Homo sapiens	62-77
26696014-1	2016	Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated necrosis that is critically dependent on glutathione peroxidase 4 (GPX4).	Iron	31-35	glutathione peroxidase 4	Mus musculus	105-129
26696014-1	2016	Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated necrosis that is critically dependent on glutathione peroxidase 4 (GPX4).	Iron	31-35	glutathione peroxidase 4	Mus musculus	131-135
29673144-0	2018	Serum Hepcidin Concentration in Individuals with Sickle Cell Anemia: Basis for the Dietary Recommendation of Iron.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	6-14
26855134-2	2016	Hepcidin, the central regulator of iron homeostasis, plays a key role in iron metabolism.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
26855134-2	2016	Hepcidin, the central regulator of iron homeostasis, plays a key role in iron metabolism.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
26855134-8	2016	These results demonstrated that Hcy up-regulated hepcidin expression through the BMP6/SMAD pathway, suggesting a novel mechanism underlying the hyperhomocysteinemia-associated perturbation of iron homeostasis.	Iron	192-196	hepcidin antimicrobial peptide	Homo sapiens	49-57
29673144-3	2018	Hepcidin is the hormone mainly responsible for iron homeostasis and intestinal absorption.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
29673144-7	2018	We aimed to compare serum hepcidin concentrations among individuals with sickle cell anemia, with or without iron overload, and those without the disease.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	26-34
26616335-1	2016	End-stage renal disease results in anemia caused by shortened erythrocyte survival, erythropoietin deficiency, hepcidin-mediated impairment of intestinal absorption and iron release, recurrent blood loss, and impaired responsiveness to erythropoiesis-stimulating agents (ESAs).	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	111-119
29673144-11	2018	These data suggest that the dietary iron intake of the SCDio group should not be reduced as higher hepcidin concentrations may reduce the intestinal absorption of iron.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	99-107
29681846-0	2018	High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein.	Iron	13-17	synuclein alpha	Homo sapiens	131-146
26730414-3	2016	Moreover, cytotoxicity assay and cell morphology observation demonstrate that LAP-Fe3O4 NPs display good biocompatibility in the given Fe concentration range, and in vivo biodistribution results prove that NPs can be metabolized and cleared out of the body.	Iron	82-84	LAP	Homo sapiens	78-81
29576218-5	2018	Introduction of the identified PMPCB variants into the homologous S. cerevisiae Mas1 protein resulted in a severe growth and MPP processing defect leading to the accumulation of mitochondrial precursor proteins and early impairment of the biogenesis of iron-sulfur clusters, which are indispensable for a broad range of crucial cellular functions.	Iron	253-257	mitochondrial processing peptidase	Saccharomyces cerevisiae S288C	80-84
26794443-6	2016	Glutathione peroxidase 4, heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively.	Iron	197-201	glutathione peroxidase 4	Homo sapiens	0-24
29305416-0	2018	Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	15-23
26794443-6	2016	Glutathione peroxidase 4, heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively.	Iron	197-201	heat shock protein family B (small) member 1	Homo sapiens	26-100
26378117-1	2016	BACKGROUND: A homozygous loss-of-function mutation p.(Arg316Gln) in the fat mass and obesity-associated (FTO) gene, which encodes for an iron and 2-oxoglutarate-dependent oxygenase, was previously identified in a large family in which nine affected individuals present with a lethal syndrome characterised by growth retardation and multiple malformations.	Iron	137-141	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	105-108
27506105-4	2016	The analysis of scientific publications demonstrated that hepcidin is a negative regulator of iron metabolism.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	58-66
29305416-6	2018	Serum levels of hepcidin, the iron regulatory peptide, remained within the physiological range, while the transferrin saturation was slightly decreased in children.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	16-24
28353202-1	2018	BACKGROUND: Most hemodialysis patients have high Hepcidin-25 levels, which may be involved in the pathogenesis of several uremic complications related to an altered iron biology.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	49-57
26945394-13	2016	Serum hepcidin showed significant positive correlations with serum iron, transferrin saturation, ferritin, and IL6 (r = 0.375, P &lt; 0.05; r = 0.453, P &lt; 0.05; r = 0.687, P &lt; 0.01; r = 0.515, P &lt; 0.01; respectively).	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	6-14
29302043-3	2018	Heme oxygenase-1 (HO) is the rate limiting enzyme in heme metabolism leading to the equimolar production of bilirubin, carbon monoxide (CO) and free iron (Fe).	Iron	149-153	heme oxygenase 1	Homo sapiens	0-16
26880214-1	2016	Ferritin-iron is currently considered as one of the most promising iron forms to prevent iron deficiency anaemia.	Iron	9-13	ferritin-1, chloroplastic	Glycine max	0-8
26880214-1	2016	Ferritin-iron is currently considered as one of the most promising iron forms to prevent iron deficiency anaemia.	Iron	67-71	ferritin-1, chloroplastic	Glycine max	0-8
26880214-2	2016	We found that the cultivation of soybean seeds in a solution of ferrous sulfate results in material with extremely high iron content - 560.6 mg Fe/100 g of dry matter, while ferritin iron content was 420.5 mg/100 g dry matter.	Iron	183-187	ferritin-1, chloroplastic	Glycine max	174-182
27236128-1	2016	The hepatic iron-regulatory hormone hepcidin and its receptor, the cellular iron exporter ferroportin, constitute a feedback-regulated mechanism that maintains adequate plasma concentrations of iron-transferrin for erythropoiesis and other functions, ensures sufficient iron stores, and avoids iron toxicity and iron-dependent microbial pathogenesis.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	36-44
27236128-1	2016	The hepatic iron-regulatory hormone hepcidin and its receptor, the cellular iron exporter ferroportin, constitute a feedback-regulated mechanism that maintains adequate plasma concentrations of iron-transferrin for erythropoiesis and other functions, ensures sufficient iron stores, and avoids iron toxicity and iron-dependent microbial pathogenesis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	36-44
27236128-1	2016	The hepatic iron-regulatory hormone hepcidin and its receptor, the cellular iron exporter ferroportin, constitute a feedback-regulated mechanism that maintains adequate plasma concentrations of iron-transferrin for erythropoiesis and other functions, ensures sufficient iron stores, and avoids iron toxicity and iron-dependent microbial pathogenesis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	36-44
27236128-1	2016	The hepatic iron-regulatory hormone hepcidin and its receptor, the cellular iron exporter ferroportin, constitute a feedback-regulated mechanism that maintains adequate plasma concentrations of iron-transferrin for erythropoiesis and other functions, ensures sufficient iron stores, and avoids iron toxicity and iron-dependent microbial pathogenesis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	36-44
27236128-2	2016	In chronic kidney disease, inflammation and impaired renal clearance increase plasma hepcidin, inhibiting duodenal iron absorption and sequestering iron in macrophages.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	85-93
27236128-3	2016	These effects of hepcidin can cause systemic iron deficiency, decreased availability of iron for erythropoiesis, and resistance to endogenous and exogenous erythropoietin.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	17-25
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Iron	131-135	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	227-232
29898329-5	2016	Matriptase-2 protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	104-112
26378394-2	2016	The hormone hepcidin is the key regulator of iron homeostasis.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	12-20
26378394-12	2016	CONCLUSIONS: Hepcidin levels that are inadequately low in relation to body iron stores are an independent predictor for incident T2DM and may contribute to diabetes-related tissue iron overload.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	13-21
26378394-12	2016	CONCLUSIONS: Hepcidin levels that are inadequately low in relation to body iron stores are an independent predictor for incident T2DM and may contribute to diabetes-related tissue iron overload.	Iron	180-184	hepcidin antimicrobial peptide	Homo sapiens	13-21
25672527-7	2016	In vitro digested fermented vegetables were able to provoke a greater hepcidin response per ng Fe than fresh vegetables, indicating that Fe in the fermented mixes was more bioavailable, independent on the soluble Fe content.	Iron	95-97	hepcidin antimicrobial peptide	Homo sapiens	70-78
25672527-7	2016	In vitro digested fermented vegetables were able to provoke a greater hepcidin response per ng Fe than fresh vegetables, indicating that Fe in the fermented mixes was more bioavailable, independent on the soluble Fe content.	Iron	137-139	hepcidin antimicrobial peptide	Homo sapiens	70-78
25672527-7	2016	In vitro digested fermented vegetables were able to provoke a greater hepcidin response per ng Fe than fresh vegetables, indicating that Fe in the fermented mixes was more bioavailable, independent on the soluble Fe content.	Iron	137-139	hepcidin antimicrobial peptide	Homo sapiens	70-78
26577567-3	2016	Furthermore, iron sequestration by monocytes/macrophages is regulated by pro-inflammatory cytokines including interleukin-1, highlighting the importance of these cells in the crosstalk between inflammation and iron homeostasis.	Iron	13-17	interleukin 1 alpha	Homo sapiens	110-123
26577567-3	2016	Furthermore, iron sequestration by monocytes/macrophages is regulated by pro-inflammatory cytokines including interleukin-1, highlighting the importance of these cells in the crosstalk between inflammation and iron homeostasis.	Iron	210-214	interleukin 1 alpha	Homo sapiens	110-123
26686468-4	2016	Clinically relevant levels of the thiosemicarbazone iron chelators triapine (Tp) and 2,2"-Dipyridyl-N,N-dimethylsemicarbazone (Dp44mT) promote selective oxidation of mitochondrial Prx3, but not cytosolic Prx1, in multiple human lung and ovarian cancer lines.	Iron	52-56	peroxiredoxin 1	Homo sapiens	204-208
26751622-3	2016	Whereas reaction of Triphos(Si) and FeX2 (X = Cl, Br) exclusively afforded (Triphos(Si))FeX2 with a kappa(2)-coordinated ligand, the homologous C-derived Fe complexes show rapid conversion in solution to afford [(Triphos)Fe(CH3CN)3][Fe2Cl6] or [(Triphos)Fe(CH3CN)3][FeBr4], respectively.	Iron	36-38	stabilin 2	Homo sapiens	88-92
27042462-10	2016	Effect of iron overload is potentially explained by positive correlation of blood transfusion and ferritin level with frequency of CD3+CD27- and that of ferritin with frequency of CD57+ T cells.	Iron	10-14	CD27 molecule	Homo sapiens	135-139
26705305-2	2016	Here, we show that human MPT synthase and ATAC inhibited PKR, a double-stranded RNA-dependent protein kinase, to facilitate translation initiation of iron-responsive mRNA.	Iron	150-154	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	57-60
26831741-12	2016	Fewer Iba1-positive microglial cells were detected at the peri-lesion area in Hpx(-/-) and HO2(-/-) mice, interestingly, which is associated with markedly increased iron-positive microglial cells.	Iron	165-169	hemopexin	Mus musculus	78-81
26831741-12	2016	Fewer Iba1-positive microglial cells were detected at the peri-lesion area in Hpx(-/-) and HO2(-/-) mice, interestingly, which is associated with markedly increased iron-positive microglial cells.	Iron	165-169	heme oxygenase 2	Mus musculus	91-94
26077449-6	2016	Chronic hepatic iron-overload showed increased nuclear localization of acetylated Forkhead fox-O-1 (FoxO1) transcription factor whereas resveratrol dietary intervention reversed the acetylation of FoxO1 in association with increased SIRT1 levels which together with its pleotropic antioxidant properties are likely key mechanisms of its therapeutic action.	Iron	16-20	forkhead box O1	Mus musculus	91-98
26077449-6	2016	Chronic hepatic iron-overload showed increased nuclear localization of acetylated Forkhead fox-O-1 (FoxO1) transcription factor whereas resveratrol dietary intervention reversed the acetylation of FoxO1 in association with increased SIRT1 levels which together with its pleotropic antioxidant properties are likely key mechanisms of its therapeutic action.	Iron	16-20	forkhead box O1	Mus musculus	100-105
26824473-1	2016	Cth2 is an mRNA-binding protein that participates in remodeling yeast cell metabolism in iron starvation conditions by promoting decay of the targeted molecules, in order to avoid excess iron consumption.	Iron	89-93	Tis11p	Saccharomyces cerevisiae S288C	0-4
26824473-1	2016	Cth2 is an mRNA-binding protein that participates in remodeling yeast cell metabolism in iron starvation conditions by promoting decay of the targeted molecules, in order to avoid excess iron consumption.	Iron	187-191	Tis11p	Saccharomyces cerevisiae S288C	0-4
26824473-2	2016	This study shows that in the absence of Cth2 immediate upregulation of expression of several of the iron regulon genes (involved in high affinity iron uptake and intracellular iron redistribution) upon oxidative stress by hydroperoxide is more intense than in wild type conditions where Cth2 is present.	Iron	100-104	Tis11p	Saccharomyces cerevisiae S288C	40-44
26824473-2	2016	This study shows that in the absence of Cth2 immediate upregulation of expression of several of the iron regulon genes (involved in high affinity iron uptake and intracellular iron redistribution) upon oxidative stress by hydroperoxide is more intense than in wild type conditions where Cth2 is present.	Iron	100-104	Tis11p	Saccharomyces cerevisiae S288C	287-291
26824473-2	2016	This study shows that in the absence of Cth2 immediate upregulation of expression of several of the iron regulon genes (involved in high affinity iron uptake and intracellular iron redistribution) upon oxidative stress by hydroperoxide is more intense than in wild type conditions where Cth2 is present.	Iron	146-150	Tis11p	Saccharomyces cerevisiae S288C	40-44
26824473-2	2016	This study shows that in the absence of Cth2 immediate upregulation of expression of several of the iron regulon genes (involved in high affinity iron uptake and intracellular iron redistribution) upon oxidative stress by hydroperoxide is more intense than in wild type conditions where Cth2 is present.	Iron	146-150	Tis11p	Saccharomyces cerevisiae S288C	287-291
26824473-2	2016	This study shows that in the absence of Cth2 immediate upregulation of expression of several of the iron regulon genes (involved in high affinity iron uptake and intracellular iron redistribution) upon oxidative stress by hydroperoxide is more intense than in wild type conditions where Cth2 is present.	Iron	146-150	Tis11p	Saccharomyces cerevisiae S288C	40-44
26824473-2	2016	This study shows that in the absence of Cth2 immediate upregulation of expression of several of the iron regulon genes (involved in high affinity iron uptake and intracellular iron redistribution) upon oxidative stress by hydroperoxide is more intense than in wild type conditions where Cth2 is present.	Iron	146-150	Tis11p	Saccharomyces cerevisiae S288C	287-291
26824473-3	2016	The oxidative stress provokes a temporary increase in the levels of Cth2 (itself a member of the iron regulon).	Iron	97-101	Tis11p	Saccharomyces cerevisiae S288C	68-72
26824473-7	2016	The observations support a role of Cth2 in modulating expression of diverse iron regulon genes, excluding those specifically involved in the reductive branch of the high-affinity transport.	Iron	76-80	Tis11p	Saccharomyces cerevisiae S288C	35-39
26800438-8	2016	In comparison with experimental results certain control arrangements can be eliminated, among them that iron homeostasis is solely based on an iron-dependent degradation of the transporter IRT1.	Iron	104-108	allograft inflammatory factor 1	Homo sapiens	189-193
26800438-8	2016	In comparison with experimental results certain control arrangements can be eliminated, among them that iron homeostasis is solely based on an iron-dependent degradation of the transporter IRT1.	Iron	143-147	allograft inflammatory factor 1	Homo sapiens	189-193
26800438-9	2016	Recent IRT1 overexpression experiments suggested that IRT1-degradation is iron-independent.	Iron	74-78	allograft inflammatory factor 1	Homo sapiens	7-11
26800438-9	2016	Recent IRT1 overexpression experiments suggested that IRT1-degradation is iron-independent.	Iron	74-78	allograft inflammatory factor 1	Homo sapiens	54-58
26800438-11	2016	We show that iron signaling pathways under IRT1 overexpression conditions become saturated, leading to a breakdown in iron regulation and to the observed iron-independent degradation of IRT1.	Iron	13-17	allograft inflammatory factor 1	Homo sapiens	43-47
26800438-11	2016	We show that iron signaling pathways under IRT1 overexpression conditions become saturated, leading to a breakdown in iron regulation and to the observed iron-independent degradation of IRT1.	Iron	13-17	allograft inflammatory factor 1	Homo sapiens	186-190
26800438-11	2016	We show that iron signaling pathways under IRT1 overexpression conditions become saturated, leading to a breakdown in iron regulation and to the observed iron-independent degradation of IRT1.	Iron	118-122	allograft inflammatory factor 1	Homo sapiens	43-47
26800438-11	2016	We show that iron signaling pathways under IRT1 overexpression conditions become saturated, leading to a breakdown in iron regulation and to the observed iron-independent degradation of IRT1.	Iron	118-122	allograft inflammatory factor 1	Homo sapiens	43-47
26805813-3	2016	The advance in understanding the main players and mechanisms involved in iron regulation significantly improved since the discovery of genes responsible for hemochromatosis, the IRE/IRPs machinery, and the hepcidin-ferroportin axis.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	206-214
26834769-2	2015	Heme oxygenase-1 (HO-1) is known as a rate-liming enzyme in the degradation of heme to biliverdin IXalpha, carbon monoxide (CO), and free iron ions (Fe(2+)).	Iron	138-142	heme oxygenase 1	Homo sapiens	18-22
26834769-2	2015	Heme oxygenase-1 (HO-1) is known as a rate-liming enzyme in the degradation of heme to biliverdin IXalpha, carbon monoxide (CO), and free iron ions (Fe(2+)).	Iron	149-151	heme oxygenase 1	Homo sapiens	18-22
26625322-6	2016	In addition, iron-response protein (IRP-1) regulatory loop was overridden by DFP as reflected by resumed level of ferritin (FTH) back to basal level and the attenuated transferrin receptor (TSFR) mRNA level suppression thereby reducing further iron uptake.	Iron	13-17	ferritin heavy chain 1	Homo sapiens	124-127
26955355-1	2015	Heparins are efficient inhibitors of hepcidin expression even in vivo, where they induce an increase of systemic iron availability.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	37-45
26154696-3	2016	Induction of hepatic hepcidin, the master hormone of iron homeostasis, causes anemia under inflammatory conditions.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	21-29
29302043-3	2018	Heme oxygenase-1 (HO) is the rate limiting enzyme in heme metabolism leading to the equimolar production of bilirubin, carbon monoxide (CO) and free iron (Fe).	Iron	155-157	heme oxygenase 1	Homo sapiens	0-16
27642598-2	2016	Dysfunction of matriptase-2 can be involved in iron regulatory disorder via downregulation of hepcidin expression.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	94-102
29473308-0	2018	A Room-Temperature Postsynthetic Ligand Exchange Strategy to Construct Mesoporous Fe-Doped CoP Hollow Triangle Plate Arrays for Efficient Electrocatalytic Water Splitting.	Iron	82-84	caspase recruitment domain family member 16	Homo sapiens	91-94
26669208-0	2016	Modulation of hepcidin to treat iron deregulation: potential clinical applications.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	14-22
26669208-1	2016	The secreted peptide hormone hepcidin regulates systemic and local iron homeostasis through degradation of the iron exporter ferroportin.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	29-37
26669208-1	2016	The secreted peptide hormone hepcidin regulates systemic and local iron homeostasis through degradation of the iron exporter ferroportin.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	29-37
26669208-2	2016	Dysregulation of hepcidin leads to altered iron homeostasis and development of pathological disorders including hemochromatosis, and iron loading and iron restrictive anemias.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	17-25
29473308-2	2018	In this work, a novel nanostructure of Fe-doped CoP hollow triangle plate arrays (Fe-CoP HTPAs) with unique mesoporous shells is designed and synthesized through a room-temperature postsynthetic ligand exchange reaction followed by a facile phosphorization treatment.	Iron	39-41	caspase recruitment domain family member 16	Homo sapiens	48-51
26669208-2	2016	Dysregulation of hepcidin leads to altered iron homeostasis and development of pathological disorders including hemochromatosis, and iron loading and iron restrictive anemias.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	17-25
26669208-2	2016	Dysregulation of hepcidin leads to altered iron homeostasis and development of pathological disorders including hemochromatosis, and iron loading and iron restrictive anemias.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	17-25
29473308-2	2018	In this work, a novel nanostructure of Fe-doped CoP hollow triangle plate arrays (Fe-CoP HTPAs) with unique mesoporous shells is designed and synthesized through a room-temperature postsynthetic ligand exchange reaction followed by a facile phosphorization treatment.	Iron	39-41	caspase recruitment domain family member 16	Homo sapiens	85-88
29473308-3	2018	The mild postsynthetic ligand exchange reaction of the presynthesized ZIF-67 TPAs with K4 [Fe(CN)6 ] in an aqueous solution at room temperature is of critical importance in achieving the final hollow nanostructure, which results in the production of CoFe(II)-PBA HTPAs that not only determine the formation of the interior voids in the nanostructure, but also provide the doping of Fe atoms to the CoP lattice.	Iron	91-93	caspase recruitment domain family member 16	Homo sapiens	398-401
29744352-3	2018	Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	54-62
26288192-0	2016	Glutathione S-transferase gene polymorphism: Relation to cardiac iron overload in Egyptian patients with Beta Thalassemia Major.	Iron	65-69	glutathione S-transferase kappa 1	Homo sapiens	0-25
29744352-3	2018	Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	54-62
25858758-10	2016	Both PM10 and iron activated the stress kinases ERK1/2 pathway, involved in the induction of TF expression.	Iron	14-18	coagulation factor III, tissue factor	Homo sapiens	93-95
29744352-4	2018	Patients with inflammatory conditions may thus have restricted availability of iron for erythropoiesis and other cell functions due to increased hepcidin expression, despite normal or high levels of serum ferritin.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	145-153
29547723-2	2018	Soil iron uptake uses the broad metal spectrum IRT1 transporter that also transports zinc, manganese, cobalt, and cadmium.	Iron	5-9	allograft inflammatory factor 1	Homo sapiens	47-51
26725908-7	2016	Now, as the main source of hepcidin, it appears that the loss of the hepcidin-producing liver mass or genetic and acquired factors that repress hepcidin synthesis in the liver may also lead to iron overload.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	69-77
26725908-7	2016	Now, as the main source of hepcidin, it appears that the loss of the hepcidin-producing liver mass or genetic and acquired factors that repress hepcidin synthesis in the liver may also lead to iron overload.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	69-77
29547723-3	2018	Sophisticated iron-dependent transcriptional regulatory mechanisms allow plants to tightly control the abundance of IRT1, ensuring optimal absorption of iron.	Iron	14-18	allograft inflammatory factor 1	Homo sapiens	116-120
26725908-9	2016	In the future, modulation of hepcidin synthesis and activity or hepcidin hormone-replacing strategies may become therapeutic options to cure iron-related disorders.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	29-37
26725908-9	2016	In the future, modulation of hepcidin synthesis and activity or hepcidin hormone-replacing strategies may become therapeutic options to cure iron-related disorders.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	64-72
29547723-3	2018	Sophisticated iron-dependent transcriptional regulatory mechanisms allow plants to tightly control the abundance of IRT1, ensuring optimal absorption of iron.	Iron	153-157	allograft inflammatory factor 1	Homo sapiens	116-120
29547723-4	2018	Here, we uncover that IRT1 acts as a transporter and receptor (transceptor), directly sensing excess of its non-iron metal substrates in the cytoplasm, to regulate its own degradation.	Iron	112-116	allograft inflammatory factor 1	Homo sapiens	22-26
29547723-7	2018	Thus, IRT1 directly senses elevated non-iron metal concentrations and integrates multiple substrate-dependent regulations to optimize iron uptake and protect plants from highly reactive metals.	Iron	40-44	allograft inflammatory factor 1	Homo sapiens	6-10
26692580-6	2016	In addition, VAT CISD1 gene expression was significantly associated with adipogenic and iron metabolism-related genes.	Iron	88-92	CDGSH iron sulfur domain 1	Homo sapiens	17-22
29127238-16	2018	Using cultured adult mouse cardiomyocytes, we demonstrated that the mechanistic target of rapamycin plays an important role in protecting cardiomyocytes against excess iron and ferroptosis.	Iron	168-172	mechanistic target of rapamycin kinase	Mus musculus	68-99
26452589-2	2016	The erythroid growth factor erythropoietin (Epo) triggers the erythropoietic induction through the activation of erythroid genes related to cell survival, differentiation, and iron metabolism.	Iron	176-180	erythropoietin	Mus musculus	28-42
28762519-7	2018	We further detected increased levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1 + IRE) in IA testes, whereas the increasing trend of iron exporter ferroportin 1 (FPN1) was not statistically significant.	Iron	88-92	doublesex and mab-3 related transcription factor 1	Homo sapiens	113-117
26452589-2	2016	The erythroid growth factor erythropoietin (Epo) triggers the erythropoietic induction through the activation of erythroid genes related to cell survival, differentiation, and iron metabolism.	Iron	176-180	erythropoietin	Mus musculus	44-47
27141568-1	2016	INTRODUCTION: Reticulocyte hemoglobin equivalent (RET-He) is a new parameter for evaluating iron status.	Iron	92-96	ret proto-oncogene	Homo sapiens	50-53
27141568-2	2016	This study aims to assess diagnostic value and investigate RET-He as early predictor of response to intravenous iron supplementation.	Iron	112-116	ret proto-oncogene	Homo sapiens	59-62
29280410-3	2018	Iron balance is under the control of a number of factors including the peptide hormone hepcidin, dietary iron intake and absorption, environmental stressors (e.g. altitude), exercise, menstrual blood loss and genetics.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	87-95
27141568-10	2016	CONCLUSION: RET-He is a useful marker of iron deficiency and early predictor of response to intravenous iron supplementation in regular hemodialysis patients.	Iron	41-45	ret proto-oncogene	Homo sapiens	12-15
27458626-2	2016	Enhanced hepcidin production mainly stimulated by excess interleukin-6 levels is a key pathodgentic component of ACD (frequently known as anemia of inflammation) by causing the degradation of the transmembrane protein ferroportin, hepcidin impairs iron metabolism.	Iron	248-252	hepcidin antimicrobial peptide	Homo sapiens	9-17
29094497-6	2018	Recent research regarding hepcidin as a central regulator of iron homeostasis is promising, but it has not been used yet for the routine diagnosis of iron deficiency anemia.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	26-34
26166253-2	2016	HO-1, a cellular stress protein, serves a vital metabolic function as the rate-limiting step in the degradation of heme to generate carbon monoxide (CO), iron, and biliverdin-IXalpha (BV), the latter which is converted to bilirubin-IXalpha (BR).	Iron	154-158	heme oxygenase 1	Homo sapiens	0-4
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	89-93	cytosolic iron-sulfur assembly component 2B	Homo sapiens	247-253
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	279-283	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	10-15
26599206-4	2015	Herein, we conjugated the Hsp70-specific antibody (cmHsp70.1) which is known to recognize mHsp70 to superparamagnetic iron nanoparticles to assess tumor-specific targeting before and after ionizing irradiation.	Iron	118-122	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	26-31
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	279-283	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	19-24
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	279-283	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	10-15
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	279-283	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	19-24
29309586-6	2018	Thus, C-HSC20 integrates initial Fe-S biosynthesis with the transfer activities of the CIA targeting system.	Iron	33-37	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	8-13
26515063-1	2015	The liver hormone hepcidin is the central regulator of systemic iron metabolism.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	18-26
29424844-3	2018	Free iron is incorporated into aggregating amyloid peptides during Abeta plaque formation and increases potential for oxidative stress surrounding plaques.	Iron	5-9	amyloid beta (A4) precursor protein	Mus musculus	67-72
26615667-2	2015	Fe(II)(TMC)(OTf)2 reacts with 2-(t)BuSO2-C6H4IO to afford an oxoiron(IV) product, 2, distinct from the previously reported [Fe(IV)(Oanti)(TMC)(NCMe)](2+).	Iron	0-2	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	7-10
26615667-2	2015	Fe(II)(TMC)(OTf)2 reacts with 2-(t)BuSO2-C6H4IO to afford an oxoiron(IV) product, 2, distinct from the previously reported [Fe(IV)(Oanti)(TMC)(NCMe)](2+).	Iron	0-2	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	138-141
29424844-4	2018	The goal of this work was to observe how brain iron levels temporally influence Abeta plaque formation, plaque iron concentration, and microgliosis.	Iron	47-51	amyloid beta (A4) precursor protein	Mus musculus	80-85
26638758-4	2015	Iron-overload increased nuclear and acetylated levels of FOXO1 with corresponding inverse changes in SIRT1 levels in the heart corrected by resveratrol therapy.	Iron	0-4	forkhead box O1	Mus musculus	57-62
26638758-4	2015	Iron-overload increased nuclear and acetylated levels of FOXO1 with corresponding inverse changes in SIRT1 levels in the heart corrected by resveratrol therapy.	Iron	0-4	sirtuin 1	Mus musculus	101-106
28666715-3	2018	The factor regulating iron stores has been identified in 2000 to be hepcidin.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	68-76
26383538-0	2015	Effect of excess iron on oxidative stress and gluconeogenesis through hepcidin during mitochondrial dysfunction.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	70-78
26383538-5	2015	Disturbances in mitochondrial function caused excess iron deposition and unbalanced expression of iron metabolism-related proteins such as hepcidin, ferritin H and ferroportin during the activation of p38 mitogen-activated protein kinase (MAPK) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), which are responsible for increased phosphoenolpyruvate carboxykinase expression.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	139-147
26383538-7	2015	Based on experiments using hepcidin shRNA and hepcidin overexpression, the activation of hepcidin affects ROS generation and iron deposition, which disturbs mitochondrial function and causes an imbalance in iron metabolism and increased gluconeogenesis.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	46-54
26383538-7	2015	Based on experiments using hepcidin shRNA and hepcidin overexpression, the activation of hepcidin affects ROS generation and iron deposition, which disturbs mitochondrial function and causes an imbalance in iron metabolism and increased gluconeogenesis.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	46-54
26383538-7	2015	Based on experiments using hepcidin shRNA and hepcidin overexpression, the activation of hepcidin affects ROS generation and iron deposition, which disturbs mitochondrial function and causes an imbalance in iron metabolism and increased gluconeogenesis.	Iron	207-211	hepcidin antimicrobial peptide	Homo sapiens	46-54
26383538-7	2015	Based on experiments using hepcidin shRNA and hepcidin overexpression, the activation of hepcidin affects ROS generation and iron deposition, which disturbs mitochondrial function and causes an imbalance in iron metabolism and increased gluconeogenesis.	Iron	207-211	hepcidin antimicrobial peptide	Homo sapiens	46-54
26383538-10	2015	Hepcidin expression may modulate this disorder by regulating ROS generation and iron deposition.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
26450372-0	2015	The late-annotated small ORF LSO1 is a target gene of the iron regulon of Saccharomyces cerevisiae.	Iron	58-62	Lso1p	Saccharomyces cerevisiae S288C	29-33
28666715-6	2018	Thus, the regulation of iron stores depends on hepcidin, while the adaptation mechanisms of iron availability in case of anemia, are mediated by an erythroid factor that could be erythroferrone.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	47-55
26450372-1	2015	We have identified a new downstream target gene of the Aft1/2-regulated iron regulon in budding yeast Saccharomyces cerevisiae, the late-annotated small open reading frame LSO1.	Iron	72-76	Lso1p	Saccharomyces cerevisiae S288C	172-176
29400974-0	2018	Bimetallic Au@M (M = Ag, Pd, Fe, and Cu) Nanoarchitectures Mediated by 1,4-Phenylene Diisocyanide Functionalization.	Iron	29-31	phosphoglycolate phosphatase	Homo sapiens	11-15
26450372-2	2015	LSO1 transcript is among the most highly induced from a transcriptome analysis of a fet3-1 mutant grown in the presence of the iron chelator bathophenanthrolinedisulfonic acid.	Iron	127-131	Lso1p	Saccharomyces cerevisiae S288C	0-4
26450372-4	2015	In contrast, we find that the LSO1 promoter region contains three consensus binding sites for the Aft1/2 transcription factors and that an LSO1-lacZ reporter is highly induced under low-iron conditions in a Aft1-dependent manner.	Iron	186-190	Lso1p	Saccharomyces cerevisiae S288C	30-34
26450372-4	2015	In contrast, we find that the LSO1 promoter region contains three consensus binding sites for the Aft1/2 transcription factors and that an LSO1-lacZ reporter is highly induced under low-iron conditions in a Aft1-dependent manner.	Iron	186-190	Lso1p	Saccharomyces cerevisiae S288C	139-143
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	75-79	Lso1p	Saccharomyces cerevisiae S288C	0-4
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	75-79	Lso1p	Saccharomyces cerevisiae S288C	104-108
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	143-147	Lso1p	Saccharomyces cerevisiae S288C	0-4
26450372-7	2015	LSO1 and LSO2 appear to play overlapping roles in the cellular response to iron starvation since single lso1 and lso2 mutants are sensitive to iron deprivation and this sensitivity is exacerbated when both genes are deleted.	Iron	143-147	Lso1p	Saccharomyces cerevisiae S288C	104-108
29237594-2	2018	Fpn is regulated by the hormone hepcidin, which induces Fpn endocytosis and cellular iron retention.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	32-40
26432957-5	2015	HO-1 degrades heme to biliverdin, carbon monoxide (CO) and free iron.	Iron	64-68	heme oxygenase 1	Homo sapiens	0-4
29237594-8	2018	The newly documented ability of hepcidin and its agonists to occlude iron transport may facilitate the development of broadly effective treatments for hereditary iron overload disorders.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	32-40
29076411-4	2018	In particular, copper, zinc and iron are recognized to influence the biochemistry of proteins involved in neurodegeneration (for instance Abeta and alpha-synuclein), as well as those playing a crucial role in neuronal development and efficiency (neurotrophins).	Iron	32-36	synuclein alpha	Homo sapiens	148-163
26572590-1	2015	Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis.	Iron	88-92	solute carrier family 11 member 2	Homo sapiens	0-32
26572590-1	2015	Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis.	Iron	88-92	solute carrier family 11 member 2	Homo sapiens	34-38
26572590-7	2015	Taken together, our studies demonstrate that decreased expression of DMT1 in intestinal mucosa leads to compromised absorption and transportation of iron and that blockade of TNF could rescue anemia and promote DMT1 expression in gut mucosa.	Iron	149-153	solute carrier family 11 member 2	Homo sapiens	69-73
29443922-3	2018	Hepcidin is a liver-derived hormone that degrades the ferroportin transport channel, thus reducing the ability of macrophages to recycle damaged iron, and decreasing iron availability.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	0-8
26396185-4	2015	Although all the erv1 and mia40 mutants exhibited defects in Mia40 oxidation, only one erv1 mutant strain (erv1-1) had significantly decreased activities of cytosolic Fe-S enzymes.	Iron	167-171	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	87-91
26396185-4	2015	Although all the erv1 and mia40 mutants exhibited defects in Mia40 oxidation, only one erv1 mutant strain (erv1-1) had significantly decreased activities of cytosolic Fe-S enzymes.	Iron	167-171	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	107-113
26396185-7	2015	The only strain to exhibit iron misregulation is the GSH-deficient erv1-1 strain, which is rescued with addition of GSH.	Iron	27-31	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	67-71
29443922-3	2018	Hepcidin is a liver-derived hormone that degrades the ferroportin transport channel, thus reducing the ability of macrophages to recycle damaged iron, and decreasing iron availability.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	0-8
29443922-9	2018	The magnitude of the response of hepcidin to exercise seems to be dependent on the pre-exercise status of iron (ferritin) and inflammation (IL-6).	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	33-41
26537957-1	2015	BACKGROUND: Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage.	Iron	95-99	ceruloplasmin	Homo sapiens	12-25
26537957-9	2015	These findings, beside the known role of ceruloplasmin in iron homeostasis, might have important pathogenic implications due to the potential triggering of signals mediated by the unusual integrin binding in cells of central nervous system.	Iron	58-62	ceruloplasmin	Homo sapiens	41-54
29228768-1	2018	Mrs3 and Mrs4 are mitochondrial inner membrane proteins that deliver an unidentified cytosolic iron species into the matrix for use in iron-sulfur cluster (ISC) and heme biosynthesis.	Iron	95-99	Fe(2+) transporter	Saccharomyces cerevisiae S288C	9-13
25598191-1	2015	In this study, mass spectrometry was used to evaluate the hepcidin-25 assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients using the absence of stainable bone marrow iron as the gold standard criterion for iron deficiency (ID).	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	58-66
29228768-1	2018	Mrs3 and Mrs4 are mitochondrial inner membrane proteins that deliver an unidentified cytosolic iron species into the matrix for use in iron-sulfur cluster (ISC) and heme biosynthesis.	Iron	135-139	Fe(2+) transporter	Saccharomyces cerevisiae S288C	9-13
29391539-1	2018	Hepcidin is a crucial peptide for regulating cellular iron efflux.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
26632477-0	2015	[Hepcidin for iron homeostasis and target therapy in ironrelated disorders].	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	1-9
29391539-2	2018	Because iron is essential for cell survival, especially for highly active cells, such as tumor cells, it is imperative to understand how tumor cells manipulate hepcidin expression for their own metabolic needs.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	160-168
29391539-5	2018	Manipulating hepcidin expression to starve cancer cells for iron may prove to be a new therapy in the anticancer arsenal.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	13-21
26512429-3	2015	The main mechanisms by which sport leads to iron deficiency are increased iron demand, elevated iron loss and blockage of iron absorption due to hepcidin bursts.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	145-153
29395073-3	2018	After studying fibroblast cell lines from subjects carrying both known and unreported biallelic mutations in CRAT and REPS1, we ascribe iron overload to the abnormal recycling of transferrin receptor (TfR1) and the reduction of TfR1 palmitoylation in NBIA.	Iron	136-140	carnitine O-acetyltransferase	Homo sapiens	109-113
29355933-0	2018	Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.	Iron	52-56	ceruloplasmin	Mus musculus	27-40
26289639-3	2015	We investigated whether the acute iron-induced increase in hepcidin influences iron absorption of successive daily iron doses and twice-daily iron doses.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	59-67
29434930-2	2018	Hepcidin is the peptide hormone, which is critically important in the regulation of systemic iron homeostasis.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	0-8
26284970-5	2015	A strong correlation between Cu-/Mn-levels as well as Fe-/Mn-levels was observed in alphaSyn-overexpressing cells.	Iron	54-56	synuclein alpha	Homo sapiens	84-92
26289753-0	2015	Iron-induced reactive oxygen species mediate transporter DMT1 endocytosis and iron uptake in intestinal epithelial cells.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	57-61
26289753-1	2015	Recent evidence shows that iron induces the endocytosis of the iron transporter dimetal transporter 1 (DMT1) during intestinal absorption.	Iron	27-31	solute carrier family 11 member 2	Homo sapiens	103-107
26289753-2	2015	We, and others, have proposed that iron-induced DMT1 internalization underlies the mucosal block phenomena, a regulatory response that downregulates intestinal iron uptake after a large oral dose of iron.	Iron	35-39	solute carrier family 11 member 2	Homo sapiens	48-52
26289753-2	2015	We, and others, have proposed that iron-induced DMT1 internalization underlies the mucosal block phenomena, a regulatory response that downregulates intestinal iron uptake after a large oral dose of iron.	Iron	160-164	solute carrier family 11 member 2	Homo sapiens	48-52
26289753-2	2015	We, and others, have proposed that iron-induced DMT1 internalization underlies the mucosal block phenomena, a regulatory response that downregulates intestinal iron uptake after a large oral dose of iron.	Iron	160-164	solute carrier family 11 member 2	Homo sapiens	48-52
28873645-3	2018	The combined effect of pH (from 7.2 to 3.2) and myoglobin oxidation state was evaluated in the reaction of nitrite with heme iron, and the observed rate constants of the reactions were determined.	Iron	125-129	myoglobin	Homo sapiens	48-57
26289753-4	2015	By means of selective surface protein biotinylation of polarized Caco-2 cells, we determined the kinetics of DMT1 internalization from the apical membrane after an iron challenge.	Iron	164-168	solute carrier family 11 member 2	Homo sapiens	109-113
26289753-5	2015	The initial decrease in DMT1 levels in the apical membrane induced by iron was followed at later times by increased levels of DMT1.	Iron	70-74	solute carrier family 11 member 2	Homo sapiens	24-28
26289753-9	2015	The decrease of DMT1 levels at the apical membrane induced by iron was associated with decreased iron uptake rates.	Iron	62-66	solute carrier family 11 member 2	Homo sapiens	16-20
26289753-9	2015	The decrease of DMT1 levels at the apical membrane induced by iron was associated with decreased iron uptake rates.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	16-20
26289753-11	2015	The model qualitatively captures the experimental observations and accurately describes the effect of iron, NAC, and DMSO on the apical distribution of DMT1.	Iron	102-106	solute carrier family 11 member 2	Homo sapiens	152-156
26289753-12	2015	Taken together, our data suggest that iron uptake induces the production of ROS, which modify DMT1 endocytic cycling, thus changing the iron transport activity at the apical membrane.	Iron	38-42	solute carrier family 11 member 2	Homo sapiens	94-98
29320706-0	2018	Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.	Iron	120-124	cytosolic iron-sulfur assembly component 2B	Homo sapiens	29-35
26289753-12	2015	Taken together, our data suggest that iron uptake induces the production of ROS, which modify DMT1 endocytic cycling, thus changing the iron transport activity at the apical membrane.	Iron	136-140	solute carrier family 11 member 2	Homo sapiens	94-98
29122540-10	2018	At the same time, with iron intervention, the concentrations of serum SOD decreased but MDA increased; the mRNA expression of osteocalcin and osteoprotegerin (OPG) decreased, whereas that of receptor activator of nuclear factor kappa B ligand (RANKL) and IL-6 increased significantly.	Iron	23-27	TNF receptor superfamily member 11B	Rattus norvegicus	142-157
26390371-0	2015	Soybean Ferritin Forms an Iron-Containing Oligomer in Tofu Even after Heat Treatment.	Iron	26-30	ferritin-1, chloroplastic	Glycine max	8-16
26390371-1	2015	Ferritin, a multimeric iron storage protein distributed in almost all living kingdoms, has been highlighted recently as a nutritional iron source in plant-derived foodstuffs, because ferritin iron is suggested to have high bioavailability.	Iron	23-27	ferritin-1, chloroplastic	Glycine max	0-8
29122540-10	2018	At the same time, with iron intervention, the concentrations of serum SOD decreased but MDA increased; the mRNA expression of osteocalcin and osteoprotegerin (OPG) decreased, whereas that of receptor activator of nuclear factor kappa B ligand (RANKL) and IL-6 increased significantly.	Iron	23-27	TNF receptor superfamily member 11B	Rattus norvegicus	159-162
26390371-1	2015	Ferritin, a multimeric iron storage protein distributed in almost all living kingdoms, has been highlighted recently as a nutritional iron source in plant-derived foodstuffs, because ferritin iron is suggested to have high bioavailability.	Iron	134-138	ferritin-1, chloroplastic	Glycine max	0-8
26390371-1	2015	Ferritin, a multimeric iron storage protein distributed in almost all living kingdoms, has been highlighted recently as a nutritional iron source in plant-derived foodstuffs, because ferritin iron is suggested to have high bioavailability.	Iron	134-138	ferritin-1, chloroplastic	Glycine max	0-8
26390371-2	2015	In soybean seeds, ferritin contributes largely to the net iron contents.	Iron	58-62	ferritin-1, chloroplastic	Glycine max	18-26
26390371-3	2015	Here, the oligomeric states and iron contents of soybean ferritin during food processing (especially tofu gel formation) were analyzed.	Iron	32-36	ferritin-1, chloroplastic	Glycine max	57-65
26390371-4	2015	Ferritin was purified from tofu gel as an iron-containing oligomer (approximately 1000 Fe atoms per oligomer), which was composed of two types of subunits similar to the native soybean seed ferritin.	Iron	42-46	ferritin-1, chloroplastic	Glycine max	0-8
29241202-1	2018	BACKGROUND/AIMS: The studies in the patients with iron deficiency anemia (IDA) implied the existence of the association of ghrelin with iron or hepcidin levels in the plasma under the pathophysiological conditions.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	144-152
26390371-4	2015	Ferritin was purified from tofu gel as an iron-containing oligomer (approximately 1000 Fe atoms per oligomer), which was composed of two types of subunits similar to the native soybean seed ferritin.	Iron	42-46	ferritin-1, chloroplastic	Glycine max	190-198
26390371-4	2015	Ferritin was purified from tofu gel as an iron-containing oligomer (approximately 1000 Fe atoms per oligomer), which was composed of two types of subunits similar to the native soybean seed ferritin.	Iron	0-2	ferritin-1, chloroplastic	Glycine max	190-198
30205391-0	2018	Long Non-Coding RNA PVT1/miR-150/ HIG2 Axis Regulates the Proliferation, Invasion and the Balance of Iron Metabolism of Hepatocellular Carcinoma.	Iron	101-105	Pvt1 oncogene	Homo sapiens	20-24
26461048-2	2015	The transport activity of ferroportin is suppressed by the peptide hormone hepcidin, which exhibits upregulated expression in chronic inflammation, causing iron-restrictive anaemia.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	75-83
30205391-14	2018	Moreover, inhibition of miR-150 could partly reverse the biological effects of PVT1 knockdown on proliferation, motility, apoptosis and iron metabolism in vitro, which might be associated with dysregulation of HIG2.	Iron	136-140	Pvt1 oncogene	Homo sapiens	79-83
29376847-0	2018	Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer"s Disease Mouse Model.	Iron	95-99	carbonic anhydrase 1	Mus musculus	27-30
26313653-8	2015	Functional iron deficiency (iron restriction due to increased levels of hepcidin) is the most common cause of preoperative anaemia, and should be treated with intravenous iron.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	72-80
26313653-8	2015	Functional iron deficiency (iron restriction due to increased levels of hepcidin) is the most common cause of preoperative anaemia, and should be treated with intravenous iron.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	72-80
28338217-1	2018	The significant positive correlation between ghrelin and iron and hepcidin levels in the plasma of children with iron deficiency anemia prompted us to hypothesize that ghrelin may affect iron metabolism.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	66-74
29590662-6	2018	Furthermore, urinary iron was significantly and positively associated with urinary 8-hydroxydeoxyguanosine, an oxidative stress marker, while no association with other markers of renal tubular injury, i.e., beta2-microglobulin and N-acetyl-beta-D-glucosaminidase, was noted.	Iron	21-25	beta-2-microglobulin	Homo sapiens	207-226
29782248-1	2018	BACKGROUND: Reported levels of hepcidin, the major regulator of systemic iron homeostasis in CHF patients, are controversial.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	31-39
29082606-8	2018	CONCLUSION: The expression of ferroportin and SLC11A2 is increased in the intestine of patients with T2D in association with iron stores and serum hepcidin levels.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	46-53
30115430-6	2018	Beside sideroblastic anemias, a number of other anemias can develop due to mutations of key proteins acting either on cellular iron transport (such as the DMT1 transporter), plasma iron transport (transferrin), and iron recycling (ceruloplasmin).	Iron	127-131	doublesex and mab-3 related transcription factor 1	Homo sapiens	155-159
30115430-7	2018	Contrasting with the aforementioned entities which involve compartmental, and sometimes, systemic iron excess, the iron refractory iron deficiency anemia (IRIDA) corresponds to a usually severe anemia with whole body iron deficiency related to chronic increase of plasma hepcidin, the systemic negative regulator of plasma iron.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	271-279
29115635-10	2018	Similarly, challenging cells with either IL-6 or leptin markedly elevated the level of secreted hepcidin (p=0.05) and this was associated with an induction in colonocyte iron levels in both cases.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	96-104
29523273-2	2018	Hepcidin, central regulator of iron homeostasis, is an antimicrobial peptide induced by inflammatory/infective stimuli.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
29054412-5	2017	The role of the endosomal divalent metal transporter 1 (DMT1) in BBB iron acquisition and transport has been questioned.	Iron	69-73	solute carrier family 11 member 2	Homo sapiens	26-54
29054412-5	2017	The role of the endosomal divalent metal transporter 1 (DMT1) in BBB iron acquisition and transport has been questioned.	Iron	69-73	solute carrier family 11 member 2	Homo sapiens	56-60
29054412-6	2017	Here, we show that inhibition of DMT1 alters the transport of iron and Tf across the endothelial cells.	Iron	62-66	solute carrier family 11 member 2	Homo sapiens	33-37
29276790-7	2017	HIF-1alpha regulates glycolytic genes whereas HIF-2alpha is known to primarily regulate genes involved in cell proliferation and iron metabolism.	Iron	129-133	endothelial PAS domain protein 1	Homo sapiens	46-56
29070546-5	2017	Additional key players are the cell membrane-associated iron transporters, particularly ferroportin (FPN), the only protein known to modulate iron export from cells, and finally, the iron-regulatory hormone hepcidin, which, in addition to having antibacterial activity, regulates the functions of FPN.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	207-215
29070551-3	2017	Although the absorption of heme iron is poorly understood, nonheme iron is transported across the apical membrane of the intestinal enterocyte by divalent metal-ion transporter 1 (DMT1) and is exported into the circulation via ferroportin 1 (FPN1).	Iron	67-71	solute carrier family 11 member 2	Homo sapiens	180-184
29070551-3	2017	Although the absorption of heme iron is poorly understood, nonheme iron is transported across the apical membrane of the intestinal enterocyte by divalent metal-ion transporter 1 (DMT1) and is exported into the circulation via ferroportin 1 (FPN1).	Iron	67-71	solute carrier family 40 member 1	Homo sapiens	227-240
29070551-3	2017	Although the absorption of heme iron is poorly understood, nonheme iron is transported across the apical membrane of the intestinal enterocyte by divalent metal-ion transporter 1 (DMT1) and is exported into the circulation via ferroportin 1 (FPN1).	Iron	67-71	solute carrier family 40 member 1	Homo sapiens	242-246
29070551-5	2017	Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	159-163
29070551-5	2017	Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm via DMT1 in the endosomal membrane.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	159-163
29070551-6	2017	This iron can be used for metabolic functions, stored within cytosolic ferritin, or exported from the cell via FPN1.	Iron	5-9	solute carrier family 40 member 1	Homo sapiens	111-115
29070551-8	2017	At the whole-body level, dietary iron absorption and iron export from the tissues into the plasma are regulated by the liver-derived peptide hepcidin.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	141-149
29070551-8	2017	At the whole-body level, dietary iron absorption and iron export from the tissues into the plasma are regulated by the liver-derived peptide hepcidin.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	141-149
29070551-9	2017	When tissue iron demands are high, hepcidin concentrations are low and vice versa.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	35-43
29070561-10	2017	The major iron transporters in the small intestine divalent metal-ion transporter 1 (DMT1) and ferroportin were not affected by pup iron status at 10 d of age but were strongly affected by iron status at 20 d of age.	Iron	10-14	solute carrier family 11 member 2	Homo sapiens	85-89
27757594-0	2017	Iron bioavailability from supplemented formula milk: effect of lactoferrin addition.	Iron	0-4	lactotransferrin	Rattus norvegicus	63-74
27757594-1	2017	PURPOSE: In this work, the absorption and/or bioavailability of iron from two chemical species, 57Fe-Lf (apo-lactoferrin) complex and 57FeSO4 at low and high dose, and in Lf excess were investigated in lactating wistar rats.	Iron	64-68	lactotransferrin	Rattus norvegicus	109-120
29059584-16	2017	Thereby, lactoferrin should be the iron replacement agent of choice for treatment of IDA in pregnancy.	Iron	35-39	lactotransferrin	Bos taurus	9-20
29105755-1	2017	Hepcidin plays a central role in systemic iron metabolism.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
29101207-3	2017	FPN1 transfers iron from the intestine, macrophages and placenta into the bloodstream.	Iron	15-19	solute carrier family 40 member 1	Homo sapiens	0-4
29101207-4	2017	In FD, loss-of-function mutations of FPN1 limit but do not impair iron export in enterocytes, but they do severely affect iron transfer in macrophages.	Iron	122-126	solute carrier family 40 member 1	Homo sapiens	37-41
28971221-4	2017	Here, we show that T2DM patients have reduced serum levels of hepcidin, the iron-regulated hormone that maintains systemic iron homeostasis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	62-70
26124203-9	2015	Maximum post-baseline changes in hepcidin levels among siltuximab recipients were correlated with maximum changes for hemoglobin (r = -0.395; P = 0.00607), total iron-binding capacity (TIBC; r = -0.354; P = 0.01694), and ferritin (r = 0.599; P = 0.0001).	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	33-41
25745821-1	2015	OBJECTIVES: The hepcidin-ferroportin system is involved in both conditions associated with iron-restricted erythropoiesis in renal anemia: iron deficiency and anemia of chronic disorders.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	16-24
25745821-9	2015	CONCLUSIONS: Thus, in anemic epoetin naive non-dialysis CKD patients, hepcidin and ferroportin expression by erythroblast and macrophage are closely related to bone marrow iron distribution.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	70-78
26024728-0	2015	Serum hepcidin concentrations correlate with serum iron level and outcome in patients with intracerebral hemorrhage.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	6-14
26024728-2	2015	Here, we investigate the association between serum hepcidin and serum iron, outcome in patients with ICH.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	51-59
26024728-5	2015	Additionally, the correlations of serum hepcidin with serum iron and the mRS score were analyzed by a generalized linear model.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	40-48
26024728-7	2015	Pearson correlation analysis showed that serum hepcidin was negatively correlated with serum iron (r = -0.5301, P &lt; 0.001), and a significantly lower concentration of serum iron was found in patients with poor outcomes (P = 0.007).	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	47-55
26024728-7	2015	Pearson correlation analysis showed that serum hepcidin was negatively correlated with serum iron (r = -0.5301, P &lt; 0.001), and a significantly lower concentration of serum iron was found in patients with poor outcomes (P = 0.007).	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	47-55
26307542-1	2015	In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability.	Iron	182-186	myb domain protein 72	Arabidopsis thaliana	47-52
26307542-2	2015	Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process that is involved in both iron acquisition and ISR signaling.	Iron	121-125	myb domain protein 72	Arabidopsis thaliana	30-35
26307542-2	2015	Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process that is involved in both iron acquisition and ISR signaling.	Iron	211-215	myb domain protein 72	Arabidopsis thaliana	30-35
26307542-4	2015	In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant"s iron-acquisition response that is typically activated upon iron starvation.	Iron	61-65	myb domain protein 72	Arabidopsis thaliana	30-35
26307542-4	2015	In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant"s iron-acquisition response that is typically activated upon iron starvation.	Iron	125-129	myb domain protein 72	Arabidopsis thaliana	30-35
26307542-4	2015	In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant"s iron-acquisition response that is typically activated upon iron starvation.	Iron	305-309	myb domain protein 72	Arabidopsis thaliana	30-35
26307542-4	2015	In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant"s iron-acquisition response that is typically activated upon iron starvation.	Iron	305-309	myb domain protein 72	Arabidopsis thaliana	30-35
26307542-7	2015	Together, these results show that the ISR- and iron acquisition-related transcription factor MYB72 in Arabidopsis roots is activated by rhizobacterial volatiles and photosynthesis-related signals, and enhances the iron-acquisition capacity of roots independently of the iron availability in the rhizosphere.	Iron	47-51	myb domain protein 72	Arabidopsis thaliana	93-98
26307542-7	2015	Together, these results show that the ISR- and iron acquisition-related transcription factor MYB72 in Arabidopsis roots is activated by rhizobacterial volatiles and photosynthesis-related signals, and enhances the iron-acquisition capacity of roots independently of the iron availability in the rhizosphere.	Iron	214-218	myb domain protein 72	Arabidopsis thaliana	93-98
26307542-7	2015	Together, these results show that the ISR- and iron acquisition-related transcription factor MYB72 in Arabidopsis roots is activated by rhizobacterial volatiles and photosynthesis-related signals, and enhances the iron-acquisition capacity of roots independently of the iron availability in the rhizosphere.	Iron	214-218	myb domain protein 72	Arabidopsis thaliana	93-98
26307542-8	2015	This work highlights the role of MYB72 in plant processes by which root microbiota simultaneously stimulate systemic immunity and activate the iron-uptake machinery in their host plants.	Iron	143-147	myb domain protein 72	Arabidopsis thaliana	33-38
26458428-3	2015	However, iron dysregulation does occasionally occur; total iron content reductions cause iron deficiency anemia and overexpression of the iron regulatory peptide hepcidin disturbs iron utilization resulting in anemia of chronic disease.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	162-170
26404443-8	2015	These novel compounds aim at correcting anemia by multiple pathways, including antagonizing the inflammation- and hepcidin-driven retention of iron in the monocyte-macrophage system and thereby promoting the supply of iron for erythropoiesis or by stimulating the endogenous formation of erythopoietin via stabilization of hypoxia-regulated factors.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	114-122
26296460-1	2015	Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster.	Iron	137-141	glutaredoxin 3	Homo sapiens	0-14
26296460-1	2015	Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster.	Iron	137-141	glutaredoxin 3	Homo sapiens	16-21
26296460-1	2015	Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster.	Iron	180-184	glutaredoxin 3	Homo sapiens	0-14
26296460-1	2015	Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster.	Iron	180-184	glutaredoxin 3	Homo sapiens	16-21
26296460-3	2015	Each iron of the iron-sulfur clusters is bound to the thiols of the cysteines, one of which is from the active site of GLRX3, the other from the noncovalently bound GSH.	Iron	5-9	glutaredoxin 3	Homo sapiens	119-124
26296460-3	2015	Each iron of the iron-sulfur clusters is bound to the thiols of the cysteines, one of which is from the active site of GLRX3, the other from the noncovalently bound GSH.	Iron	17-21	glutaredoxin 3	Homo sapiens	119-124
26296460-5	2015	[4Fe-4S] cluster-containing GLRX3 is competent for converting iron regulatory protein 1 (apo-IRP1) into aconitase within 30 min, via intact iron-sulfur cluster transfer.	Iron	62-66	glutaredoxin 3	Homo sapiens	28-33
26296460-6	2015	These in vitro studies suggest that human GLRX3 is important for cytosolic Fe-S protein maturation.	Iron	75-79	glutaredoxin 3	Homo sapiens	42-47
26252621-2	2015	Oxidative stress derived from the iron accumulated in the amyloid plaques originating from amyloid beta (Abeta) peptides and neurofibrillary tangles derived from hyperphosphorylated tau proteins has been implicated in the pathogenesis of Alzheimer"s disease (AD).	Iron	34-38	microtubule associated protein tau	Homo sapiens	182-185
26267011-4	2015	Of primary importance are the pyridine-bis(imine) ligands (herein referred to as PDI), which produced iron catalysts that are among the world"s most active for ethylene polymerization, demonstrated "staying power" despite over 15 years of ligand improvement efforts, and generated highly active polymerization systems with cobalt, chromium, and vanadium.	Iron	102-106	peptidyl arginine deiminase 1	Homo sapiens	81-84
26267011-5	2015	Although many ligands have been employed in iron-catalyzed polymerization, the PDI family has thus far provided the most information about iron"s capabilities and tendencies.	Iron	44-48	peptidyl arginine deiminase 1	Homo sapiens	79-82
26267011-5	2015	Although many ligands have been employed in iron-catalyzed polymerization, the PDI family has thus far provided the most information about iron"s capabilities and tendencies.	Iron	139-143	peptidyl arginine deiminase 1	Homo sapiens	79-82
26267011-7	2015	Iron PDI polymerizes propylene with 2,1-regiochemistry via a predominantly isotactic, chain end control mechanism.	Iron	0-4	peptidyl arginine deiminase 1	Homo sapiens	5-8
26267011-8	2015	Because the first insertion proceeds via 1,2-regiochemistry, iron (and cobalt) PDI systems can be tailored to make highly linear dimers of alpha-olefins by "head-to-head" coupling, resulting from a switch in regiochemistry after the first insertion.	Iron	61-65	peptidyl arginine deiminase 1	Homo sapiens	79-82
26405158-11	2015	Thus, HO-1 is an essential enzyme for iron-dependent lipid peroxidation during ferroptotic cell death.	Iron	38-42	heme oxygenase 1	Homo sapiens	6-10
26235306-5	2015	Moreover, the acute toxicity of the three NAC effluents significantly decreased after treatment with ZVI.	Iron	101-104	synuclein alpha	Homo sapiens	42-45
25774043-8	2015	Hepcidin was highly stimulated by FeDex supplementation and attenuated the inflammation of anemia, which implied that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	0-8
25774043-8	2015	Hepcidin was highly stimulated by FeDex supplementation and attenuated the inflammation of anemia, which implied that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	118-126
26235415-7	2015	The availability of iron is controlled by hepcidin that is synthesized in the liver as a response to radiation-induced inflammatory.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	42-50
26235415-8	2015	The presence of hepcidin blocks iron absorption in the intestine and decreases its recycling from senescent red blood cells.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	16-24
25430937-0	2015	ADAMTS13 Levels in Young Patients With beta-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.	Iron	125-129	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	0-8
25753988-0	2015	Increased duodenal iron absorption through up-regulation of divalent metal transporter 1 from enhancement of iron regulatory protein 1 activity in patients with nonalcoholic steatohepatitis.	Iron	19-23	solute carrier family 11 member 2	Homo sapiens	60-88
25753988-12	2015	CONCLUSION: In spite of elevation of serum hepcidin, iron absorption from the GI tract increased through up-regulation of DMT1 by IRP1 activation by humoral factor(s) in sera of patients with NASH.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	122-126
28971221-4	2017	Here, we show that T2DM patients have reduced serum levels of hepcidin, the iron-regulated hormone that maintains systemic iron homeostasis.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	62-70
26301810-2	2015	Here, we investigated the effect of iron on the hormone leptin, which regulates food intake and energy homeostasis.	Iron	36-40	leptin	Mus musculus	56-62
26301810-6	2015	Treatment of 3T3-L1 adipocytes with iron decreased leptin mRNA in a dose-dependent manner.	Iron	36-40	leptin	Mus musculus	51-57
28971221-8	2017	In addition, the liver correctly senses increased circulating iron levels by activating the BMP/SMAD signaling pathway even though hepcidin expression is decreased.	Iron	62-66	bone morphogenetic protein 1	Homo sapiens	92-95
26301810-7	2015	We found that iron negatively regulates leptin transcription via cAMP-responsive element binding protein activation (CREB activation) and identified 2 potential CREB-binding sites in the mouse leptin promoter region.	Iron	14-18	leptin	Mus musculus	40-46
28971221-11	2017	As a result, metabolic perturbations induce an "iron resistance" phenotype, whereby signals that translate increased circulating iron levels into hepcidin production, are dysregulated.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	146-154
26301810-7	2015	We found that iron negatively regulates leptin transcription via cAMP-responsive element binding protein activation (CREB activation) and identified 2 potential CREB-binding sites in the mouse leptin promoter region.	Iron	14-18	leptin	Mus musculus	193-199
26301810-11	2015	These findings indicate that levels of dietary iron play an important role in regulation of appetite and metabolism through CREB-dependent modulation of leptin expression.	Iron	47-51	leptin	Mus musculus	153-159
29245263-4	2017	A 53-year-old man who had a history of iron wire ingestion went to our hospital, on examination, he only had slight abdominal tenderness due to swallowing a ball pen and 1 cap nut 1 day before, radiological imaging showed penetrating renal trauma, the blood test showed his renal function is normal.	Iron	39-43	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	162-165
26405701-0	2015	The Relationship of Serum Hemojuvelin and Hepcidin Levels with Iron Overload in Nonalcoholic Fatty Liver Disease.	Iron	63-67	hemojuvelin BMP co-receptor	Homo sapiens	26-37
26405701-0	2015	The Relationship of Serum Hemojuvelin and Hepcidin Levels with Iron Overload in Nonalcoholic Fatty Liver Disease.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	42-50
26405701-2	2015	Hepcidin is the master iron-regulatory peptide and hemojuvelin (HJV) is the key regulator of iron-dependent secretion of hepcidin.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
26405701-7	2015	Iron-overloaded NAFLD patients had significantly lower HJV (249.9 [187.6-296.3] vs. 292.9 [243-435] ng/ml, p=0.032) and significantly higher hepcidin (78.4+/-35.5 vs. 56.5+/-28.9ng/ml, p=0.027) levels than NAFLD patients without iron overload.	Iron	0-4	hemojuvelin BMP co-receptor	Homo sapiens	55-58
29390526-1	2017	Bone morphogenetic proteins (BMPs) are important regulators of iron metabolism affecting hepcidin expression.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	89-97
26405701-7	2015	Iron-overloaded NAFLD patients had significantly lower HJV (249.9 [187.6-296.3] vs. 292.9 [243-435] ng/ml, p=0.032) and significantly higher hepcidin (78.4+/-35.5 vs. 56.5+/-28.9ng/ml, p=0.027) levels than NAFLD patients without iron overload.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	141-149
26405701-10	2015	CONCLUSIONS: Our findings suggest that HJV levels are low in NAFLD and even lower in iron overloaded NAFLD, while hepcidin levels are higher in NAFLD with iron overload.	Iron	85-89	hemojuvelin BMP co-receptor	Homo sapiens	39-42
26405701-10	2015	CONCLUSIONS: Our findings suggest that HJV levels are low in NAFLD and even lower in iron overloaded NAFLD, while hepcidin levels are higher in NAFLD with iron overload.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	114-122
26405701-11	2015	The gradually decreased HJV and increased hepcidin concentrations in our patients most likely reflect the physiological response to iron accumulation in the liver.	Iron	132-136	hemojuvelin BMP co-receptor	Homo sapiens	24-27
26405701-11	2015	The gradually decreased HJV and increased hepcidin concentrations in our patients most likely reflect the physiological response to iron accumulation in the liver.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	42-50
29129410-3	2017	Hepcidin plays a crucial role in maintaining iron homeostasis.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
29129410-4	2017	Hepcidin expression is directly regulated by variations in iron intake and its repression leads to an increase in bioavailable serum iron level.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	0-8
26711617-0	2015	[Testing the influence of lipid laden and iron-overloading on ceruloplasmin expression in RAW 264.7 cells].	Iron	42-46	ceruloplasmin	Mus musculus	62-75
29129410-4	2017	Hepcidin expression is directly regulated by variations in iron intake and its repression leads to an increase in bioavailable serum iron level.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	0-8
29153377-9	2017	It has been postulated that the main pathophysiological pathway leading to these events might involve the pleiotropic master hormone hepcidin, which regulates iron metabolism, leading to activation of macrophages in atherosclerotic plaques and then to clinical cardiovascular events.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	133-141
26290281-2	2015	However, the biological correlation of serum hepcidin, a key regulator of iron homeostasis, with liver malfunction is undefined.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	45-53
26290281-8	2015	Our findings suggest that increased serum hepcidin may reflect a protective response to the iron status and elevated serum cytokines during liver injury.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	42-50
29158016-3	2017	For most HC forms (types 1, 2, 3 and 4B HC) iron overload is related to cellular hepcidin deprivation which causes an increase of plasma iron concentration and the appearance of plasma non-transferrin bound iron.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	81-89
26291319-1	2015	Hepcidin is the master regulator of iron homeostasis in vertebrates.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
26291319-2	2015	The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	17-25
29158016-3	2017	For most HC forms (types 1, 2, 3 and 4B HC) iron overload is related to cellular hepcidin deprivation which causes an increase of plasma iron concentration and the appearance of plasma non-transferrin bound iron.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	81-89
26291319-3	2015	While the role of hepcidin in iron regulation is well established, its contribution to host defense is emerging as complex and multifaceted.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	18-26
26291319-5	2015	Hepcidin induction during infection causes depletion of extracellular iron, which is thought to be a general defense mechanism against many infections by withholding iron from invading pathogens.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
26291319-5	2015	Hepcidin induction during infection causes depletion of extracellular iron, which is thought to be a general defense mechanism against many infections by withholding iron from invading pathogens.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	0-8
26291319-6	2015	Conversely, by promoting iron sequestration in macrophages, hepcidin may be detrimental to cellular defense against certain intracellular infections, although critical in vivo studies are needed to confirm this concept.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	60-68
29158016-3	2017	For most HC forms (types 1, 2, 3 and 4B HC) iron overload is related to cellular hepcidin deprivation which causes an increase of plasma iron concentration and the appearance of plasma non-transferrin bound iron.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	81-89
29209212-1	2017	The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	58-66
26178764-2	2015	The two-photon excited fluorescence (TPEF) probe shows a fluorescence enhancement (FE) by a factor of about three in the presence of 160 mM K(+), independently of one-photon (OP, 430 nm) or two-photon (TP, 860 nm) excitation and comparable K(+)-induced FEs in the presence of competitive Na(+) ions.	Iron	253-256	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	37-41
29209212-1	2017	The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	58-66
26125411-10	2015	Pharmacologic manipulation of iron metabolism may represent a promising approach to limiting TLR4-mediated inflammatory responses.	Iron	30-34	toll like receptor 4	Homo sapiens	93-97
29209212-2	2017	Inflammatory disorders and malignancies are often associated with high hepcidin levels, leading to ferroportin down-regulation, iron sequestration in tissue macrophages and subsequent anemia.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	71-79
29209212-5	2017	Large and small molecule antagonists inhibiting hepcidin-mediated ferroportin internalization were identified, and unique insights into the requirements for interaction between these two key iron homeostasis molecules are provided.	Iron	191-195	hepcidin antimicrobial peptide	Homo sapiens	48-56
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	4-8	solute carrier family 22, member 17	Rattus norvegicus	207-244
26004810-1	2015	The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during neurodegeneration.	Iron	4-8	solute carrier family 22, member 17	Rattus norvegicus	246-250
28963992-4	2017	UV-visible spectra study demonstrated that compounds 11p and 11r bound to IDO1 and coordinated with the heme iron.	Iron	109-113	indoleamine 2,3-dioxygenase 1	Homo sapiens	74-78
26004810-9	2015	Apo-LCN2 without iron caused no significant differences in neuronal Bim expression or cell survival, whereas holo-LCN2 consisting of LCN2:iron:enterochelin complex increased Bim mRNA expression and decreased neuronal survival.	Iron	138-142	Bcl2-like 11	Rattus norvegicus	174-177
26251568-7	2015	RESULTS: The mechanism of interaction between host cells and lactoferrin have shown various aspects of gene expression and cellular activity depending on the degree of iron saturation of lactoferrin.	Iron	168-172	lactotransferrin	Bos taurus	61-72
26251568-7	2015	RESULTS: The mechanism of interaction between host cells and lactoferrin have shown various aspects of gene expression and cellular activity depending on the degree of iron saturation of lactoferrin.	Iron	168-172	lactotransferrin	Bos taurus	187-198
28815688-2	2017	The bone morphogenetic protein (BMP)-SMAD signaling pathway, through the ligand BMP6 and the co-receptor hemojuvelin, is a central regulator of hepcidin transcription in the liver in response to iron.	Iron	195-199	bone morphogenetic protein 6	Mus musculus	80-84
26251568-13	2015	The presence of iron in lactoferrin plays an important role in enhancing the various activities taking place inside these cells.	Iron	16-20	lactotransferrin	Bos taurus	24-35
25663339-1	2015	Scrap Cu-modified cast iron (CMCI) is a potent material for the reduction of 2,4-dinitrotoluene (2,4-DNT) by a surface-mediated reaction.	Iron	23-27	5', 3'-nucleotidase, cytosolic	Homo sapiens	101-104
28815688-3	2017	Here, we show that dietary iron loading has a residual ability to induce Smad signaling and hepcidin expression in Bmp6-/- mice, effects that are blocked by a neutralizing BMP2/4 antibody.	Iron	27-31	bone morphogenetic protein 6	Mus musculus	115-119
25663339-3	2015	Results show that the 2,4-DNT reduction was significantly affected by Cu:Fe mass ratio and the optimum m(Cu:Fe) was 0.25%.	Iron	73-75	5', 3'-nucleotidase, cytosolic	Homo sapiens	26-29
28806678-3	2017	Total iron (Fe) contents were 16.50, 24.40, and 13.08% for nZVI/BB, nZVI/PBB and nZVI/HBB, respectively.	Iron	6-10	hemoglobin subunit beta	Homo sapiens	86-89
25663339-3	2015	Results show that the 2,4-DNT reduction was significantly affected by Cu:Fe mass ratio and the optimum m(Cu:Fe) was 0.25%.	Iron	108-110	5', 3'-nucleotidase, cytosolic	Homo sapiens	26-29
25663339-13	2015	The operational conditions and common ions affected the 2,4-DNT reduction and its products by enhancing the corrosion of iron or accumulating a passive oxide film on the reactivity sites.	Iron	121-125	5', 3'-nucleotidase, cytosolic	Homo sapiens	60-63
28806678-3	2017	Total iron (Fe) contents were 16.50, 24.40, and 13.08% for nZVI/BB, nZVI/PBB and nZVI/HBB, respectively.	Iron	12-14	hemoglobin subunit beta	Homo sapiens	86-89
28833367-3	2017	The influence of thyroid hormones on the synthesis/regulation of hepcidin, an important regulator of iron metabolism, remains uncharacterized.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	65-73
29032957-23	2017	INTERPRETATION: In iron-depleted women, providing iron supplements daily as divided doses increases serum hepcidin and reduces iron absorption.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	106-114
29032957-23	2017	INTERPRETATION: In iron-depleted women, providing iron supplements daily as divided doses increases serum hepcidin and reduces iron absorption.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	106-114
28667819-2	2017	In Arabidopsis, Trichoderma-ISR relies on the transcription factor MYB72, which plays a dual role in the onset of ISR and the activation of Fe uptake responses.	Iron	140-142	myb domain protein 72	Arabidopsis thaliana	67-72
28789952-11	2017	CONCLUSION: The Tyr113His T/C variant of rs1051740 and VS phenotype alters EPHX1, miR-26b-5p and miR-1207-5p expression, and contributes towards low blood iron levels and LBW.	Iron	155-159	epoxide hydrolase 1	Homo sapiens	75-80
28789952-11	2017	CONCLUSION: The Tyr113His T/C variant of rs1051740 and VS phenotype alters EPHX1, miR-26b-5p and miR-1207-5p expression, and contributes towards low blood iron levels and LBW.	Iron	155-159	microRNA 26b	Homo sapiens	82-89
29073189-0	2017	Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice.	Iron	69-73	erythropoietin	Mus musculus	10-24
29073189-2	2017	The aim of the study was to determine the effect of erythropoietin administration on proteins participating in the control of iron homeostasis in the liver and spleen in C57BL/6 and mask mice.	Iron	126-130	erythropoietin	Mus musculus	52-66
29068390-3	2017	At a systemic level, iron homeostasis is controlled by the liver-secreted hormone hepcidin.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	82-90
29068390-10	2017	We here review and discuss novel concepts of hypoxia signaling that could help to better understand hepcidin-associated iron overload in ALD.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	100-108
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	24-28	solute carrier family 11 member 2	Homo sapiens	133-137
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	72-76	solute carrier family 11 member 2	Homo sapiens	103-131
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	72-76	solute carrier family 11 member 2	Homo sapiens	133-137
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	72-76	solute carrier family 40 member 1	Homo sapiens	140-153
29061112-6	2017	The levels of alpha-Syn, APP and amyloid beta-peptide (Abeta) as well as protein aggregation can be down-regulated by IRPs but are up-regulated in the presence of iron accumulation.	Iron	163-167	synuclein alpha	Homo sapiens	14-23
27729173-0	2017	Intestinal expression of genes implicated in iron absorption and their regulation by hepcidin.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	85-93
25820186-1	2015	BACKGROUND: Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury.	Iron	91-95	heme oxygenase 1	Homo sapiens	58-74
25820186-1	2015	BACKGROUND: Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury.	Iron	91-95	heme oxygenase 1	Homo sapiens	76-80
25981695-13	2015	Our study demonstrated that iron depletion controlled the expression of Egr1, which might contribute to decisions about cellular fate in response to iron deficiency.	Iron	28-32	early growth response 1	Homo sapiens	72-76
25693854-11	2015	In addition, a decrease in vimentin along an increase in E-cadherin in renal gene expression was observed in CKD rats with iron chelation.	Iron	123-127	cadherin 1	Rattus norvegicus	57-67
25693854-13	2015	Similarly, increased renal gene expression of CD68, tumor necrosis factor-alpha and monocyte chemoattractant protein-1 was suppressed in CKD rats with iron chelation.	Iron	151-155	C-C motif chemokine ligand 2	Rattus norvegicus	84-118
25778985-0	2015	Regulation of Iron Uptake by IRT1: Endocytosis Pulls the Trigger.	Iron	14-18	allograft inflammatory factor 1	Homo sapiens	29-33
25284586-0	2015	Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress.	Iron	103-107	myeloid zinc finger 1	Homo sapiens	0-21
25284586-0	2015	Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress.	Iron	103-107	myeloid zinc finger 1	Homo sapiens	23-28
25284586-8	2015	Inhibition of MZF-1 expression led to reduced FPN concentration, coupled with resultant intracellular iron retention, increased iron-related cellular activities and enhanced tumor cell growth.	Iron	102-106	myeloid zinc finger 1	Homo sapiens	14-19
25284586-8	2015	Inhibition of MZF-1 expression led to reduced FPN concentration, coupled with resultant intracellular iron retention, increased iron-related cellular activities and enhanced tumor cell growth.	Iron	128-132	myeloid zinc finger 1	Homo sapiens	14-19
25284586-9	2015	In contrast, increase of MZF-1 expression restrained tumor cell growth by promoting FPN-driven iron egress.	Iron	95-99	myeloid zinc finger 1	Homo sapiens	25-30
26124661-0	2015	Oral administration of iron-saturated bovine lactoferrin-loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism.	Iron	23-27	lactotransferrin	Bos taurus	45-56
25989751-8	2015	An intermediary compound FexLi2-2xF2, attributed to iron substituted in the LiF lattice, has been identified using XPS.	Iron	52-56	LIF interleukin 6 family cytokine	Homo sapiens	76-79
25875786-7	2015	Among all ten proteins associated with LCN2; highest confidence of prediction were seen for the associations between LCN2 and metalloproteinase 9 (MMP9) and lipoprotein receptor-related protein 2 (LRP2) which play vital roles in tumor growth and iron transportation, respectively.	Iron	246-250	matrix metallopeptidase 9	Gallus gallus	147-151
25997831-1	2015	The Jumonji domain-containing protein 6 (Jmjd6) is a member of the superfamily of non-haem iron(II) and 2-oxoglutarate (2OG)-dependent oxygenases; it plays an important developmental role in higher animals.	Iron	91-95	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	4-39
25997831-1	2015	The Jumonji domain-containing protein 6 (Jmjd6) is a member of the superfamily of non-haem iron(II) and 2-oxoglutarate (2OG)-dependent oxygenases; it plays an important developmental role in higher animals.	Iron	91-95	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	41-46
25997831-5	2015	Jmjd6 does catalyse 2OG-dependent C-5 hydroxylation of lysine residues in mRNA splicing-regulatory proteins and histones; there is also accumulating evidence that Jmjd6 plays a role in splicing (potentially in an iron- and oxygen-dependent manner) as well as in other processes regulating gene expression, including transcriptional pause release.	Iron	213-217	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
25997831-5	2015	Jmjd6 does catalyse 2OG-dependent C-5 hydroxylation of lysine residues in mRNA splicing-regulatory proteins and histones; there is also accumulating evidence that Jmjd6 plays a role in splicing (potentially in an iron- and oxygen-dependent manner) as well as in other processes regulating gene expression, including transcriptional pause release.	Iron	213-217	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	163-168
25782630-1	2015	Hepcidin is the key regulator of iron absorption and recycling, and its expression is suppressed by red blood cell production.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
25978588-5	2015	Dicarbonyls Fe(PN(R)py)(CO)2 were produced by treating PN(Me)py with Fe(benzylideneacetone)(CO)3 and reduction of FeX2(PN(Ph)py) with NaBEt3H under a CO atmosphere.	Iron	12-14	stabilin 2	Homo sapiens	114-118
25843360-5	2015	Following exposure to VOSO4, there was an increase (336+-73%) in RNA for divalent metal transporter 1 (DMT1), a major iron importer.	Iron	118-122	solute carrier family 11 member 2	Homo sapiens	73-101
25843360-5	2015	Following exposure to VOSO4, there was an increase (336+-73%) in RNA for divalent metal transporter 1 (DMT1), a major iron importer.	Iron	118-122	solute carrier family 11 member 2	Homo sapiens	103-107
25904736-0	2015	Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	9-17
25904736-2	2015	Consequently, hepcidin may be a key determinant of the iron homeostasis and anemia associated with poorer HIV prognoses.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	14-22
25904736-3	2015	OBJECTIVE: The objective of this study was to understand how hepcidin is related to anemia, iron homeostasis, and inflammation at HIV diagnosis and to investigate associations between hepcidin and all-cause mortality in HIV infection.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	61-69
25904736-7	2015	Increasing hepcidin was associated with iron homeostasis biomarkers (higher ferritin and lower transferrin, hemoglobin, and sTfR), inflammation (higher ACT), and key health indicators (lower CD4 or BMI, advancing age, and male gender; P &lt; 0.001 except for hemoglobin, P = 0.021).	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	11-19
25904736-10	2015	CONCLUSIONS: Elevated hepcidin is independently associated with greater mortality in men and women with HIV infection, and hepcidin is also part of a complex relation linking iron homeostasis, anemia, and HIV.	Iron	175-179	hepcidin antimicrobial peptide	Homo sapiens	123-131
26521482-2	2015	Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron, indicating that there is a certain link between iron and alpha-synuclein aggregation.	Iron	77-81	synuclein alpha	Homo sapiens	0-15
26521482-2	2015	Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron, indicating that there is a certain link between iron and alpha-synuclein aggregation.	Iron	77-81	synuclein alpha	Homo sapiens	140-155
26521482-2	2015	Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron, indicating that there is a certain link between iron and alpha-synuclein aggregation.	Iron	131-135	synuclein alpha	Homo sapiens	0-15
26521482-2	2015	Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron, indicating that there is a certain link between iron and alpha-synuclein aggregation.	Iron	131-135	synuclein alpha	Homo sapiens	140-155
27729173-1	2017	BACKGROUND &amp; AIMS: Through inhibition of iron absorption and iron mobilization from tissue stores, hepcidin exerts a negative control on iron homeostasis.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	103-111
26521482-3	2015	Iron promotes alpha-synuclein aggregation by increasing its synthesis and decreasing its degradation.	Iron	0-4	synuclein alpha	Homo sapiens	14-29
26521482-4	2015	Also, alpha-synuclein regulates iron metabolism through its ferrireductase activity.	Iron	32-36	synuclein alpha	Homo sapiens	6-21
27729173-1	2017	BACKGROUND &amp; AIMS: Through inhibition of iron absorption and iron mobilization from tissue stores, hepcidin exerts a negative control on iron homeostasis.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	103-111
27729173-1	2017	BACKGROUND &amp; AIMS: Through inhibition of iron absorption and iron mobilization from tissue stores, hepcidin exerts a negative control on iron homeostasis.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	103-111
27729173-2	2017	Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release from cells to plasma.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
25608116-7	2015	Furthermore, iron-induced phosphorylation of Smad1/5/8 was not detected in the livers of Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice.	Iron	13-17	SMAD family member 1	Mus musculus	45-54
27729173-2	2017	Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release from cells to plasma.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	60-64
27729173-2	2017	Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release from cells to plasma.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	0-8
27729173-2	2017	Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release from cells to plasma.	Iron	168-172	solute carrier family 40 member 1	Homo sapiens	60-64
27729173-4	2017	Aim of the present study was to further investigate the regulation of iron absorption by hepcidin.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	89-97
27729173-7	2017	RESULTS: In samples that had not been exposed to hepcidin, correlations were found between the expression of genes involved in iron absorption: DMT1, Fpn1, Dcytb and HCP1.	Iron	127-131	doublesex and mab-3 related transcription factor 1	Homo sapiens	144-148
25993535-7	2015	FTH-DCs exhibited increased iron storage capacity, and displayed a significantly higher transverse relaxation rate (R2*) as compared to DCs in phantom.	Iron	28-32	ferritin heavy chain 1	Homo sapiens	0-3
27729173-7	2017	RESULTS: In samples that had not been exposed to hepcidin, correlations were found between the expression of genes involved in iron absorption: DMT1, Fpn1, Dcytb and HCP1.	Iron	127-131	solute carrier family 40 member 1	Homo sapiens	150-154
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	58-66
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	58-66
25972165-3	2015	NOS1AP/nNOS interaction regulates small GTPases, iron transport, p38MAPK-linked excitotoxicity, and anxiety.	Iron	49-53	nitric oxide synthase 1 adaptor protein	Homo sapiens	0-6
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	58-66
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	58-66
25943368-10	2015	CONCLUSION: Although most of the DFP-treated patients displayed clinical and radiological improvements, those with the lower CP activity appeared to respond better to iron chelation.	Iron	167-171	ceruloplasmin	Homo sapiens	125-127
27745814-0	2017	Hepatic iron content is independently associated with serum hepcidin levels in subjects with obesity.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	60-68
25943891-1	2015	BACKGROUND: Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	12-20
25943891-1	2015	BACKGROUND: Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	34-38
25943891-1	2015	BACKGROUND: Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores.	Iron	148-153	hepcidin antimicrobial peptide	Homo sapiens	12-20
27745814-1	2017	BACKGROUND &amp; AIMS: Serum hepcidin concentration is known to increase in parallel to circulating markers of iron stores.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	29-37
25943891-1	2015	BACKGROUND: Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores.	Iron	148-153	hepcidin antimicrobial peptide	Homo sapiens	34-38
25943891-2	2015	Abnormal levels of HAMP expression alter plasma iron parameters and lead to iron metabolism disorders.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	19-23
27745814-8	2017	In multivariate regression analysis, hepatic iron content (p &lt; 0.01) and serum ferritin (p &lt; 0.001) contributed independently to circulating hepcidin concentration variation after controlling for age, gender, BMI and hsCRP.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	147-155
25943891-2	2015	Abnormal levels of HAMP expression alter plasma iron parameters and lead to iron metabolism disorders.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	19-23
27745814-11	2017	CONCLUSIONS: Serum hepcidin is a reliable marker of the hepatic iron content in subjects with obesity.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	19-27
28370178-1	2017	Hepcidin, secreted by hepatocytes, controls iron metabolism by limiting iron egress in plasma.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
25976966-1	2015	Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	16-24
25976966-2	2015	Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
28370178-1	2017	Hepcidin, secreted by hepatocytes, controls iron metabolism by limiting iron egress in plasma.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
25976966-2	2015	Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
25976966-2	2015	Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
28600663-0	2017	Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	6-14
25976966-4	2015	Furthermore, a number of strategies that target hepcidin, its receptor, and its regulators are under development as novel therapeutic approaches for diseases associated with iron dysregulation.	Iron	174-178	hepcidin antimicrobial peptide	Homo sapiens	48-56
25788583-0	2015	Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.	Iron	69-73	ceruloplasmin	Mus musculus	15-28
25788583-4	2015	OBJECTIVE: The aim was to study the role of hephaestin (HEPH) and ceruloplasmin (CP) in CNS iron metabolism and homeostasis.	Iron	92-96	ceruloplasmin	Mus musculus	66-79
25788583-4	2015	OBJECTIVE: The aim was to study the role of hephaestin (HEPH) and ceruloplasmin (CP) in CNS iron metabolism and homeostasis.	Iron	92-96	ceruloplasmin	Mus musculus	81-83
28600663-1	2017	OBJECTIVES: To investigate potential usefulness of serum hepcidin in the diagnosis of iron overload in children with beta-thalassemia.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	57-65
28600663-9	2017	Iron overload [serum ferritin (SF) &gt;= 1500 ng/ml] was independently associated with TM (p = 0.001) and elevated serum hepcidin (p = 0.02).	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	121-129
28600663-10	2017	The overall predictability of serum hepcidin in severe iron overload was statistically significant when compared to hepcidin to serum ferritin ratio.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	36-44
28600663-11	2017	CONCLUSIONS: Serum hepcidin is elevated in children with beta-thalassemia; but this elevation is more evident in TM patients with severe iron overload.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	19-27
28600663-12	2017	Thus, hepcidin can be a potential marker of severe iron overload in patients with TM.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	6-14
25659646-1	2015	UNLABELLED: Hepcidin is a central regulator in human iron metabolism.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	12-20
28600663-13	2017	Further studies are recommended to compare serum hepcidin and serum ferritin in the prediction of severe iron overload in steady state and during infection or inflammation.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	49-57
25659646-6	2015	These findings suggest a possible role of prolactin in regulation of hepcidin, and may render hepcidin a useful biomarker for progress monitoring and treatment of iron-related diseases under hyperprolactinemic conditions.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	94-102
28775066-2	2017	At the systemic level, iron homeostasis is controlled by the liver-derived hormone hepcidin acting on its target ferroportin in the gut, spleen, and liver, which form the sites of iron uptake, recycling, and storage, respectively.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	83-91
25659646-7	2015	FROM THE CLINICAL EDITOR: The level of hepcidin has been shown to reflect the underlying iron status of the patient.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	39-47
26571689-1	2015	Hepcidin are small cationic peptides with antibacterial activity expressed mainly in the liver of living organisms, and they play important roles in the host"s immune response against microbial invasion and regulation of iron metabolism.	Iron	221-225	hepcidin	Oreochromis niloticus	0-8
28775066-2	2017	At the systemic level, iron homeostasis is controlled by the liver-derived hormone hepcidin acting on its target ferroportin in the gut, spleen, and liver, which form the sites of iron uptake, recycling, and storage, respectively.	Iron	180-184	hepcidin antimicrobial peptide	Homo sapiens	83-91
25764944-9	2015	Iron homeostasis also differed between early and delayed TB-progressors, with higher ferritin and hepcidin concentrations observed among early TB-progressors (mean ferritin 50.2 vs. 26.2 ng/ml; P = 0.027; mean hepcidin 37.7 vs. 5.6 ng/ml; P = 0.036).	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	98-106
28775066-8	2017	These include the recognition that the hepcidin/ferroportin axis plays a vital role in the regulation of intracellular iron homeostasis as well as regulating systemic iron availability.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	39-47
28775066-8	2017	These include the recognition that the hepcidin/ferroportin axis plays a vital role in the regulation of intracellular iron homeostasis as well as regulating systemic iron availability.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	39-47
28775066-9	2017	As is the case for other aspects of iron homeostasis, hypoxia significantly modulates the function of the hepcidin/ferroportin pathway in the heart.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	106-114
28840425-1	2017	In liver hepatocytes, the HFE gene regulates cellular and systemic iron homeostasis by modulating cellular iron-uptake and producing the iron-hormone hepcidin in response to systemic iron elevation.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	150-158
25941530-0	2015	Arbuscular mycorrhizal symbiosis alters the expression patterns of three key iron homeostasis genes, ZmNAS1, ZmNAS3, and ZmYS1, in S deprived maize plants.	Iron	77-81	nicotianamine synthase 3	Zea mays	109-115
25941530-0	2015	Arbuscular mycorrhizal symbiosis alters the expression patterns of three key iron homeostasis genes, ZmNAS1, ZmNAS3, and ZmYS1, in S deprived maize plants.	Iron	77-81	iron-phytosiderophore transporter yellow stripe 1	Zea mays	121-126
29022497-2	2017	Recent studies have suggested that estrogen (E2) disrupts intracellular iron homeostasis by reducing hepcidin synthesis and maintaining ferroportin integrity.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	101-109
25860887-0	2015	Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?	Iron	89-93	bone morphogenetic protein 6	Mus musculus	0-4
25860887-0	2015	Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?	Iron	141-145	bone morphogenetic protein 6	Mus musculus	0-4
25860887-1	2015	Bmp6 is the main activator of hepcidin, the liver hormone that negatively regulates plasma iron influx by degrading the sole iron exporter ferroportin in enterocytes and macrophages.	Iron	91-95	bone morphogenetic protein 6	Mus musculus	0-4
25860887-1	2015	Bmp6 is the main activator of hepcidin, the liver hormone that negatively regulates plasma iron influx by degrading the sole iron exporter ferroportin in enterocytes and macrophages.	Iron	125-129	bone morphogenetic protein 6	Mus musculus	0-4
25860887-2	2015	Bmp6 expression is modulated by iron but the molecular mechanisms are unknown.	Iron	32-36	bone morphogenetic protein 6	Mus musculus	0-4
25860887-5	2015	With manipulation of dietary iron in wild-type mice, Bmp6 and Tfr1 expression in both HCs and NPCs was inversely related, as expected.	Iron	29-33	bone morphogenetic protein 6	Mus musculus	53-57
25491917-0	2015	Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane.	Iron	14-18	doublesex and mab-3 related transcription factor 1	Homo sapiens	82-86
25491917-2	2015	DMT1, which mediates iron transport across cell membranes, is located at the plasma membrane of enterocytes and imports dietary iron into the cytosol.	Iron	21-25	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
25491917-2	2015	DMT1, which mediates iron transport across cell membranes, is located at the plasma membrane of enterocytes and imports dietary iron into the cytosol.	Iron	128-132	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
28963827-1	2017	In non-dialysis-chronic kidney disease (CKD), iron deficiency is a frequent nutritional disorder due to either the greater tendency to occult gastrointestinal bleeding or to the chronic inflammatory state resulting in a reduced intestinal iron reabsorption through an increased synthesis of hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	291-299
25491917-3	2015	TfR1 is not directly engaged in the intestinal absorption of free iron, and iron uptake by DMT1 is attenuated by ferristatin II treatment.	Iron	76-80	doublesex and mab-3 related transcription factor 1	Homo sapiens	91-95
28688222-2	2017	The biogenesis of complex iron sulfur molybdoenzymes (CISM) requires use of a system specific chaperone - a redox enzyme maturation protein (REMP) - to help mediate final folding and assembly.	Iron	26-30	solute carrier family 16 member 8	Homo sapiens	108-139
25059214-1	2015	Hepcidin is a key player in the regulation of mammalian iron homeostasis.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
25059214-2	2015	Because iron overload may be one of the causes of osteoporosis, hepcidin may have therapeutic potential for osteoporosis patients.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	64-72
28688222-2	2017	The biogenesis of complex iron sulfur molybdoenzymes (CISM) requires use of a system specific chaperone - a redox enzyme maturation protein (REMP) - to help mediate final folding and assembly.	Iron	26-30	solute carrier family 16 member 8	Homo sapiens	141-145
25614087-1	2015	BACKGROUND: Obesity is associated with decreased iron status, possibly due to a rise in hepcidin, an inflammatory protein known to reduce iron absorption.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	88-96
28901363-1	2017	Density functional theory (DFT, B3LYP-D3 with implicit solvation in toluene) was used to investigate the mechanisms of olefin hydrosilylation catalyzed by PDI(Fe) (bis(imino)pyridine iron) complexes, where PDI = 2,6-(ArN[double bond, length as m-dash]CMe)2(C5H3N) with Ar = 2,6-R2-C6H3.	Iron	183-187	peptidyl arginine deiminase 1	Homo sapiens	155-158
25614087-10	2015	Maternal hepcidin levels were correlated with maternal iron status (sTFR r=0.2 P=0.025), but not with neonatal values.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	9-17
28901363-2	2017	We find that the rate-determining step for hydrosilylation is hydride migration from Et3SiH onto the Fe-bound olefin to form (PDI)Fe(alkyl)(SiEt3).	Iron	101-103	peptidyl arginine deiminase 1	Homo sapiens	126-129
28878310-7	2017	A total of 400-450 g of rhLF protein, which shows similar enzymatic activity to natural hLF in iron binding and release, can be purified on a large scale from &gt;100 L of milk per day.	Iron	95-99	HLF transcription factor, PAR bZIP family member	Homo sapiens	25-28
25822525-4	2015	Cardiac iron overload resulted in increased oxidative stress and gene expression of the inflammatory mediators tumor necrosis factor-alpha, interleukin-10 and interferon gamma, as well as matrix metalloproteinases-2 and -9.	Iron	8-12	interleukin 10	Rattus norvegicus	140-154
25822525-4	2015	Cardiac iron overload resulted in increased oxidative stress and gene expression of the inflammatory mediators tumor necrosis factor-alpha, interleukin-10 and interferon gamma, as well as matrix metalloproteinases-2 and -9.	Iron	8-12	interferon gamma	Rattus norvegicus	159-175
25815883-1	2015	In a previous study, we showed that the silencing of the heavy subunit (FHC) offerritin, the central iron storage molecule in the cell, is accompanied by a modification in global gene expression.	Iron	101-105	low density lipoprotein receptor	Homo sapiens	72-75
25815883-9	2015	Taken all together, our data indicate that, in our experimental model, FHC silencing may affect RAF1/pERK1/2 levels through the modulation of a specific set of miRNAs and add new insights in to the relationship among iron homeostasis and miRNAs.	Iron	217-221	low density lipoprotein receptor	Homo sapiens	71-74
28763236-8	2017	Both hLF-hinge-CH2-CH3 and hLF-CH2-CH3 exhibited iron-binding activity, superior uptake by Caco-2 cells, similar thermal stability, and longer plasma half-life compared to recombinant hLF.	Iron	49-53	HLF transcription factor, PAR bZIP family member	Homo sapiens	5-8
25635054-1	2015	Mutations in transferrin receptor 2 (TfR2) cause a rare form of the hereditary hemochromatosis, resulting in iron overload predominantly in the liver.	Iron	109-113	transferrin receptor 2	Homo sapiens	13-35
25635054-1	2015	Mutations in transferrin receptor 2 (TfR2) cause a rare form of the hereditary hemochromatosis, resulting in iron overload predominantly in the liver.	Iron	109-113	transferrin receptor 2	Homo sapiens	37-41
25635054-2	2015	TfR2 is primarily expressed in hepatocytes and is hypothesized to sense iron levels in the blood to positively regulate the expression of hepcidin through activation of the BMP signaling pathway.	Iron	72-76	transferrin receptor 2	Homo sapiens	0-4
28877469-6	2017	Cells expressing an amyotrophic lateral sclerosis (ALS)-associated TBK1 allele are incapable of degrading ferritin suggesting a molecular mechanism that explains the presence of iron deposits in patient brain biopsies.	Iron	178-182	TANK binding kinase 1	Homo sapiens	67-71
25635054-2	2015	TfR2 is primarily expressed in hepatocytes and is hypothesized to sense iron levels in the blood to positively regulate the expression of hepcidin through activation of the BMP signaling pathway.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	138-146
25635054-3	2015	Hepcidin is a peptide hormone that negatively regulates iron egress from cells and thus limits intestinal iron uptake.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
25635054-3	2015	Hepcidin is a peptide hormone that negatively regulates iron egress from cells and thus limits intestinal iron uptake.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
28874699-5	2017	Combining laser ablation inductively coupled plasma mass spectrometry and immunohistochemistry, iron and copper were evident at very low levels in regions of alpha-synuclein aggregation.	Iron	96-100	synuclein alpha	Homo sapiens	158-173
26380338-3	2015	Cross-sectional studies report that iron might be associated with increased malaria morbidity, raising fears that current iron supplementation policies will cause harm in the present context of increasing resistance against intermittent preventive treatment in pregnancy (IPTp).	Iron	36-40	tRNA isopentenyltransferase 1	Homo sapiens	272-276
29043237-2	2017	Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
26380338-11	2015	High iron levels (measured by the log10 of ferritin corrected on inflammation) were significantly associated with increased risk of a positive blood smear (adjusted odds ratio = 1.75; 95% CI, 1.46-2.11; P &lt; .001) and high P falciparum density (beta estimate = 0.22; 95% CI, 0.18-0.27; P &lt; .001) during the follow-up period adjusted on pregnancy parameters, comorbidities, environmental and socioeconomic indicators, and IPTp regime.	Iron	5-9	tRNA isopentenyltransferase 1	Homo sapiens	426-430
26380338-14	2015	Iron levels were positively associated with increased PAM during pregnancy in the context of IPTp.	Iron	0-4	tRNA isopentenyltransferase 1	Homo sapiens	93-97
29043237-2	2017	Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-8
28824242-0	2017	Evaluation of Iron Overload in the Heart and Liver Tissue by Magnetic Resonance Imaging and its Relation to Serum Ferritin and Hepcidin Concentrations in Patients with Thalassemia Syndromes.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	127-135
28824242-2	2017	We aimed to evaluate iron accumulation in the heart and liver by MRI in thalassemia major, thalassemia intermedia, and S-ss thalassemia patients and to examine its association with ferritin and hepcidin levels.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	194-202
25768944-0	2015	Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.	Iron	0-4	chemokine (C-X-C motif) receptor 3	Mus musculus	78-83
28824242-11	2017	We considered that, enhanced intestinal iron absorption characterized by decreased serum hepcidin levels in the intervals between successive transfusions were resulted in iron accumulation in our patients.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	89-97
28824242-11	2017	We considered that, enhanced intestinal iron absorption characterized by decreased serum hepcidin levels in the intervals between successive transfusions were resulted in iron accumulation in our patients.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	89-97
28824243-0	2017	Effect of Intravenous Iron Supplementation on Hepcidin Levels in Iron Deficient Pregnant Females in Second and Third Trimester.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	46-54
28824243-0	2017	Effect of Intravenous Iron Supplementation on Hepcidin Levels in Iron Deficient Pregnant Females in Second and Third Trimester.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	46-54
25526737-7	2015	SR, especially high-energy (56)Fe or (28)Si ions markedly decreased sphingosine-1-phosphate levels and Akt- and p38 MAPK phosphorylation, depleted anti-senescence sirtuin-1 and increased biochemical markers of autophagy.	Iron	31-33	sirtuin 1	Mus musculus	163-172
28824243-1	2017	Objective of the study was to assess effect of iron therapy on serum hepcidin levels in iron deficient pregnant women and its correlation with hemoglobin, serum iron profile and C-reactive protein (CRP).	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	69-77
28824243-1	2017	Objective of the study was to assess effect of iron therapy on serum hepcidin levels in iron deficient pregnant women and its correlation with hemoglobin, serum iron profile and C-reactive protein (CRP).	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	69-77
28824243-1	2017	Objective of the study was to assess effect of iron therapy on serum hepcidin levels in iron deficient pregnant women and its correlation with hemoglobin, serum iron profile and C-reactive protein (CRP).	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	69-77
25485477-4	2015	The cytochrome c/H2O2-induced liposome leakage was suppressed upon increasing the ionic strength, in contrast to the leakage provoked by Fe/ascorbate, suggesting that the binding of cyt c to negatively-charged membranes was required for the permeabilization process.	Iron	137-139	cytochrome c	Bos taurus	182-187
28983190-5	2017	Furthermore, our data strongly support that complexes between histone deacetylase 8 and poly r(C)-binding protein 1 are specific, and that they are equally strong when both zinc and iron-loaded proteins are involved, or perhaps mildly promoted in the latter case, suggesting an in vivo role for the non-canonical, iron-incorporated histone deacetylase.	Iron	182-186	histone deacetylase 8	Homo sapiens	62-83
25485477-5	2015	The cyt c/H2O2-induced liposome leakage was abolished by cyanide presumably competing with H2O2 for coordination with the central iron atom of the heme in cyt c.	Iron	130-134	cytochrome c	Bos taurus	4-9
25485477-5	2015	The cyt c/H2O2-induced liposome leakage was abolished by cyanide presumably competing with H2O2 for coordination with the central iron atom of the heme in cyt c.	Iron	130-134	cytochrome c	Bos taurus	155-160
25600857-9	2015	Elevated serum leptin levels were significantly associated with good nutritional status parameters, such as higher albumin (p = 0.001), prealbumin (p = 0.033), total iron binding capacity (p = 0.045), total cholesterol (p = 0.041), and lower malnutrition inflammation score (MIS) (p = 0.002).	Iron	166-170	leptin	Homo sapiens	15-21
28983190-5	2017	Furthermore, our data strongly support that complexes between histone deacetylase 8 and poly r(C)-binding protein 1 are specific, and that they are equally strong when both zinc and iron-loaded proteins are involved, or perhaps mildly promoted in the latter case, suggesting an in vivo role for the non-canonical, iron-incorporated histone deacetylase.	Iron	314-318	histone deacetylase 8	Homo sapiens	62-83
25595343-3	2015	In this study, three newly designed thiosemicarbazone iron chelators, TSC24, Dp44mT and 3-AP, were tested for in vitro activity against bloodstream forms of Trypanosoma brucei and human leukaemia HL-60 cells.	Iron	54-58	testis expressed 35	Homo sapiens	70-75
28451750-11	2017	When grown in alkaline soil, Pro MYB72 :bHLH104-GFP plants greatly improved the seed yield and Fe concentration.	Iron	95-97	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	40-47
25595343-7	2015	Iron supplementation partly reversed the trypanotoxic and cytotoxic activity of TSC24 and Dp44mT but not of 3-AP.	Iron	0-4	testis expressed 35	Homo sapiens	80-85
28451750-12	2017	These results are fundamental for plant manipulation approaches to modify tolerance to Fe deficiency and Fe accumulation through alterations of bHLH104 gene expression.	Iron	87-89	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	144-151
25564095-0	2015	Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.	Iron	33-37	thioredoxin	Homo sapiens	72-83
28655781-0	2017	The hepatocyte-specific HNF4alpha/miR-122 pathway contributes to iron overload-mediated hepatic inflammation.	Iron	65-69	microRNA 122	Mus musculus	34-41
25564095-0	2015	Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.	Iron	33-37	peroxiredoxin 5	Homo sapiens	102-123
25425685-0	2015	Rapid elevation of transferrin saturation and serum hepcidin concentration in hemodialysis patients after intravenous iron infusion.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	52-60
25648629-7	2015	Here we give a brief overview on alphaSyn pathology and the role of metals in the brain and then address in more detail the interaction of alphaSyn with three disease-relevant transition metals, iron (Fe), copper (Cu) and manganese (Mn).	Iron	195-199	synuclein alpha	Homo sapiens	139-147
25648629-7	2015	Here we give a brief overview on alphaSyn pathology and the role of metals in the brain and then address in more detail the interaction of alphaSyn with three disease-relevant transition metals, iron (Fe), copper (Cu) and manganese (Mn).	Iron	201-203	synuclein alpha	Homo sapiens	139-147
25852110-1	2015	Hepcidin is a key regulator of iron homeostasis and plays a role in the pathogenesis of anaemia of chronic disease.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
25852110-5	2015	Furthermore, since hepcidin is associated with iron accumulation in macrophages in the vessel wall inducing oxidative stress and atherosclerosis, it has been speculated that hepcidin might function as a biomarker of cardiovascular disease.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	19-27
25852110-5	2015	Furthermore, since hepcidin is associated with iron accumulation in macrophages in the vessel wall inducing oxidative stress and atherosclerosis, it has been speculated that hepcidin might function as a biomarker of cardiovascular disease.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	174-182
25520048-7	2015	Tightly controlled iron metabolism is essential for insulin secretion and insulin sensitivity, and iron overload in pancreatic islets alters reactive oxygen species (ROS) generation, as well as hypoxia-inducible factor-1alpha (HIF-1alpha) stability and adenosine triphosphate (ATP) synthesis, thereby impairing the function and viability of beta-cells.	Iron	99-103	hypoxia inducible factor 1, alpha subunit	Mus musculus	194-225
25520048-7	2015	Tightly controlled iron metabolism is essential for insulin secretion and insulin sensitivity, and iron overload in pancreatic islets alters reactive oxygen species (ROS) generation, as well as hypoxia-inducible factor-1alpha (HIF-1alpha) stability and adenosine triphosphate (ATP) synthesis, thereby impairing the function and viability of beta-cells.	Iron	99-103	hypoxia inducible factor 1, alpha subunit	Mus musculus	227-237
25678434-0	2015	TfR2 links iron metabolism and erythropoiesis.	Iron	11-15	transferrin receptor 2	Homo sapiens	0-4
25562424-2	2015	It was later demonstrated that hepcidin is the long-sought hormone that regulates iron homeostasis in mammals.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	31-39
25578484-1	2015	Myoglobin (Mb) and hemoglobin have the biological ability to carry/store oxygen (O2), a property which requires its heme iron atom to be in the ferrous--Fe(II)--state.	Iron	121-125	myoglobin	Homo sapiens	0-9
25486930-0	2015	Hereditary hypotransferrinemia can lead to elevated transferrin saturation and, when associated to HFE or HAMP mutations, to iron overload.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	106-110
25454304-4	2015	The main pathway resulting in iron overload is through altered hepcidin levels.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	63-71
25467637-2	2015	Nedd4 family-interacting protein 1 (Ndfip1), an adaptor protein for the Nedd4 family of ubiquitin ligases, played an essential role in regulating DMT1 and iron homeostasis in human cortical neurons.	Iron	155-159	Nedd4 family interacting protein 1	Homo sapiens	0-34
25467637-2	2015	Nedd4 family-interacting protein 1 (Ndfip1), an adaptor protein for the Nedd4 family of ubiquitin ligases, played an essential role in regulating DMT1 and iron homeostasis in human cortical neurons.	Iron	155-159	Nedd4 family interacting protein 1	Homo sapiens	36-42
25467637-2	2015	Nedd4 family-interacting protein 1 (Ndfip1), an adaptor protein for the Nedd4 family of ubiquitin ligases, played an essential role in regulating DMT1 and iron homeostasis in human cortical neurons.	Iron	155-159	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	0-5
25467637-4	2015	Further study showed that the decrease of Ndfip1 occurred earlier than the increase of DMT1 with iron-responsive element (DMT1 + IRE) in 6-OHDA-treated MES23.5 cells, indicating that the decrease of Ndfip1 might be involved in the increase of DMT1 + IRE.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	87-91
25467637-4	2015	Further study showed that the decrease of Ndfip1 occurred earlier than the increase of DMT1 with iron-responsive element (DMT1 + IRE) in 6-OHDA-treated MES23.5 cells, indicating that the decrease of Ndfip1 might be involved in the increase of DMT1 + IRE.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	122-126
25467637-4	2015	Further study showed that the decrease of Ndfip1 occurred earlier than the increase of DMT1 with iron-responsive element (DMT1 + IRE) in 6-OHDA-treated MES23.5 cells, indicating that the decrease of Ndfip1 might be involved in the increase of DMT1 + IRE.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	122-126
25467637-5	2015	In addition, we demonstrated that overexpression of Ndfip1 caused DMT1 + IRE downregulation, resulting in the decreased iron influx and iron-induced neurotoxicity.	Iron	120-124	solute carrier family 11 member 2	Homo sapiens	66-70
25467637-5	2015	In addition, we demonstrated that overexpression of Ndfip1 caused DMT1 + IRE downregulation, resulting in the decreased iron influx and iron-induced neurotoxicity.	Iron	136-140	solute carrier family 11 member 2	Homo sapiens	66-70
25448225-5	2015	The transduction of FTH led to a significant enhancement in cellular iron storage capacity and caused hypointensity and a significant increase in R2 * values of FTH-hMSC-collected phantoms and FTH-hMSC-transplanted sites of the brain, as shown by in vitro and in vivo MRI performed at 9.4 T, compared with control hMSCs.	Iron	69-73	ferritin heavy chain 1	Homo sapiens	20-23
25592008-0	2015	Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula.	Iron	0-4	lactotransferrin	Bos taurus	48-59
25592008-1	2015	OBJECTIVE: The aim of this study was to evaluate whether an iron-fortified formula with a concentration of lactoferrin would significantly improve the hematologic indexes and iron status in term infants compared with those same values in infants fed an iron-fortified formula without lactoferrin.	Iron	60-64	lactotransferrin	Bos taurus	107-118
25592008-1	2015	OBJECTIVE: The aim of this study was to evaluate whether an iron-fortified formula with a concentration of lactoferrin would significantly improve the hematologic indexes and iron status in term infants compared with those same values in infants fed an iron-fortified formula without lactoferrin.	Iron	60-64	lactotransferrin	Bos taurus	284-295
25592008-1	2015	OBJECTIVE: The aim of this study was to evaluate whether an iron-fortified formula with a concentration of lactoferrin would significantly improve the hematologic indexes and iron status in term infants compared with those same values in infants fed an iron-fortified formula without lactoferrin.	Iron	175-179	lactotransferrin	Bos taurus	107-118
25592008-1	2015	OBJECTIVE: The aim of this study was to evaluate whether an iron-fortified formula with a concentration of lactoferrin would significantly improve the hematologic indexes and iron status in term infants compared with those same values in infants fed an iron-fortified formula without lactoferrin.	Iron	175-179	lactotransferrin	Bos taurus	107-118
25482508-0	2015	Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis.	Iron	90-94	Fas cell surface death receptor	Homo sapiens	34-38
25482508-4	2015	Coherent effects of genes involved in iron homeostasis and pharmacological modulation of iron levels revealed a link between intracellular iron and Fas/CD95 exon 6 inclusion.	Iron	38-42	Fas cell surface death receptor	Homo sapiens	152-156
25482508-4	2015	Coherent effects of genes involved in iron homeostasis and pharmacological modulation of iron levels revealed a link between intracellular iron and Fas/CD95 exon 6 inclusion.	Iron	89-93	Fas cell surface death receptor	Homo sapiens	152-156
25482508-4	2015	Coherent effects of genes involved in iron homeostasis and pharmacological modulation of iron levels revealed a link between intracellular iron and Fas/CD95 exon 6 inclusion.	Iron	89-93	Fas cell surface death receptor	Homo sapiens	152-156
25482508-5	2015	A splicing regulatory network linked iron levels with reduced activity of the Zinc-finger-containing splicing regulator SRSF7, and in vivo and in vitro assays revealed that iron inhibits SRSF7 RNA binding.	Iron	173-177	serine and arginine rich splicing factor 7	Homo sapiens	120-125
25482508-5	2015	A splicing regulatory network linked iron levels with reduced activity of the Zinc-finger-containing splicing regulator SRSF7, and in vivo and in vitro assays revealed that iron inhibits SRSF7 RNA binding.	Iron	173-177	serine and arginine rich splicing factor 7	Homo sapiens	187-192
25236856-1	2015	Over expression of hepcidin antimicrobial peptide is a common feature of iron-restricted anemia in humans.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	19-27
25236856-6	2015	Bone marrow erythroid progenitors from erythropoietin-treated mice exhibited iron-restricted erythropoiesis, as indicated by increased median fluorescence intensity of transferrin receptor immunostaining by flow cytometry.	Iron	77-81	erythropoietin	Mus musculus	39-53
25236856-10	2015	RAP-011 may, therefore, be an appropriate therapeutic for trials in human anemias characterized by increased expression of hepcidin antimicrobial peptide and iron-restricted erythropoiesis.	Iron	158-162	LDL receptor related protein associated protein 1	Homo sapiens	0-3
25440391-7	2015	The key iron regulatory protein hepcidin, activated in response to inflammation, inhibits absorption of iron from the gastrointestinal tract and further reduces bioavailability of iron stores for red cell production.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	32-40
25440391-7	2015	The key iron regulatory protein hepcidin, activated in response to inflammation, inhibits absorption of iron from the gastrointestinal tract and further reduces bioavailability of iron stores for red cell production.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	32-40
25440391-7	2015	The key iron regulatory protein hepcidin, activated in response to inflammation, inhibits absorption of iron from the gastrointestinal tract and further reduces bioavailability of iron stores for red cell production.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	32-40
26120227-5	2015	RESULTS: In the present study, the lactase activity was markedly reduced in iron-deficient rats.	Iron	76-80	lactase	Rattus norvegicus	35-42
26118202-1	2015	BACKGROUND: Hepcidin is a 25-amino peptide hormone that regulates iron homeostasis.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	12-20
26118202-3	2015	Diurnal levels of serum iron might affect hepcidin secretion during the day.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	42-50
26023012-8	2015	(5) The index of arterial stiffness was aggravated in MHD patients and was associated with serum hepcidin and TNF-alpha levels, which could inhibit iron exit from cells.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	97-105
26023012-11	2015	Cardiovascular disease has been shown to be linked to oxidative stress caused by iron sequestration in vascular cells and macrophages as well as by the alteration of iron metabolism in mitochondria, and the observed increase in hepcidin and TNF-alpha may accelerate these crucial steps of oxidative stress in vascular disease.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	228-236
28655781-7	2017	In addition, both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR-122.	Iron	18-22	microRNA 122	Mus musculus	226-233
26637694-5	2015	Oral iron salts correct absolute iron deficiency in most patients, because low hepcidin levels facilitate iron absorption.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	79-87
28692195-0	2017	Homologous Catalysts Based on Fe-Doped CoP Nanoarrays for High-Performance Full Water Splitting under Benign Conditions.	Iron	30-32	caspase recruitment domain family member 16	Homo sapiens	39-42
26637695-3	2015	Functional iron deficiency, mediated principally by the interaction of interleukin-6, the iron regulatory hormone hepcidin, and the iron exporter ferroportin, is a major contributor to the anemia of chronic disease.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	114-122
26637695-3	2015	Functional iron deficiency, mediated principally by the interaction of interleukin-6, the iron regulatory hormone hepcidin, and the iron exporter ferroportin, is a major contributor to the anemia of chronic disease.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	114-122
25300398-11	2015	Administration of exogenous BMP7 was effective in correcting the plasma iron level and bone loss, indicating that BMP6 is an essential but not exclusive in vivo regulator of iron homeostasis.	Iron	174-178	bone morphogenetic protein 6	Mus musculus	114-118
28692195-3	2017	Iron-doped cobalt phosphate borate nanoarray on carbon cloth (Fe-Co-Pi-Bi/CC) derived from iron-doped cobalt phosphide on CC (Fe-CoP/CC) through oxidative polarization behaves as a highly active bimetallic electrocatalyst for water oxidation with an overpotential of 382 mV to afford a catalytic current density of 10 mA cm-2 in 0.1 m potassium borate (K-Bi, pH 9.2).	Iron	0-4	caspase recruitment domain family member 16	Homo sapiens	129-132
25315861-7	2015	We used a cell culture model of the BBB to show the presence of factors that influence iron release in non-human primate cerebrospinal fluid and conditioned media from astrocytes; specifically apo-transferrin and hepcidin were found to increase and decrease iron release, respectively.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	213-221
28692195-3	2017	Iron-doped cobalt phosphate borate nanoarray on carbon cloth (Fe-Co-Pi-Bi/CC) derived from iron-doped cobalt phosphide on CC (Fe-CoP/CC) through oxidative polarization behaves as a highly active bimetallic electrocatalyst for water oxidation with an overpotential of 382 mV to afford a catalytic current density of 10 mA cm-2 in 0.1 m potassium borate (K-Bi, pH 9.2).	Iron	91-95	caspase recruitment domain family member 16	Homo sapiens	129-132
25315861-7	2015	We used a cell culture model of the BBB to show the presence of factors that influence iron release in non-human primate cerebrospinal fluid and conditioned media from astrocytes; specifically apo-transferrin and hepcidin were found to increase and decrease iron release, respectively.	Iron	258-262	hepcidin antimicrobial peptide	Homo sapiens	213-221
28692195-3	2017	Iron-doped cobalt phosphate borate nanoarray on carbon cloth (Fe-Co-Pi-Bi/CC) derived from iron-doped cobalt phosphide on CC (Fe-CoP/CC) through oxidative polarization behaves as a highly active bimetallic electrocatalyst for water oxidation with an overpotential of 382 mV to afford a catalytic current density of 10 mA cm-2 in 0.1 m potassium borate (K-Bi, pH 9.2).	Iron	62-64	caspase recruitment domain family member 16	Homo sapiens	129-132
28842660-7	2017	The technique was developed and tested with data collected at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Complex (J-PARC) for an iron sample.	Iron	171-175	cullin 9	Homo sapiens	158-162
28704607-5	2017	Notably, the developed COP-TPP(Fe)@MOF-900 exhibits a 16 mV positive half-wave potential compared with the benchmarked Pt/C.	Iron	31-33	caspase recruitment domain family member 16	Homo sapiens	23-26
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	microRNA 31	Homo sapiens	86-92
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	microRNA 145	Homo sapiens	113-120
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	microRNA 149	Homo sapiens	122-129
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	doublesex and mab-3 related transcription factor 1	Homo sapiens	234-238
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	solute carrier family 40 member 1	Homo sapiens	249-253
28715216-6	2017	Furthermore, LIH repressed almost 50% of the expression of FET3, FTR1, SIT1, and TIS11 genes in Saccharomyces cerevisiae cells, indicating increasing iron provided in cells and improved iron nutrition in citrus.	Iron	150-154	Tis11p	Saccharomyces cerevisiae S288C	81-86
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Iron	20-22	pyruvate dehydrogenase complex component X	Homo sapiens	98-102
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Iron	20-22	pyruvate dehydrogenase complex component X	Homo sapiens	330-334
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Iron	143-145	pyruvate dehydrogenase complex component X	Homo sapiens	98-102
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Iron	143-145	pyruvate dehydrogenase complex component X	Homo sapiens	330-334
28615441-2	2017	Systemic iron homeostasis is regulated by the liver-derived peptide hormone, hepcidin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	77-85
28615455-2	2017	A number of important proteins control iron homeostasis, including hepcidin and ferroportin, in various cells.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	67-75
28615456-3	2017	Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the only known mammalian cellular iron exporter ferroportin.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
28615456-3	2017	Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the only known mammalian cellular iron exporter ferroportin.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
28615456-3	2017	Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the only known mammalian cellular iron exporter ferroportin.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
28615456-4	2017	Hepcidin is feedback-regulated by iron status and strongly modulated by inflammation and erythropoietic demand.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
28651980-1	2017	Docking studies of 4-phenylthiazolinethione on human IDO1 suggest complexation of the heme iron by the exocyclic sulfur atom further reinforced by hydrophobic interactions of the phenyl ring within pocket A of the enzyme.	Iron	91-95	indoleamine 2,3-dioxygenase 1	Homo sapiens	53-57
28476637-0	2017	The critical role of Nramp1 in degrading alpha-synuclein oligomers in microglia under iron overload condition.	Iron	86-90	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	21-27
28476637-0	2017	The critical role of Nramp1 in degrading alpha-synuclein oligomers in microglia under iron overload condition.	Iron	86-90	synuclein, alpha	Mus musculus	41-56
28476637-2	2017	In this study, concomitant with the accumulation of iron and oligomeric alpha-synuclein, higher expression of a lysosomal iron transporter, natural resistance-associated macrophage protein-1 (Nramp1), was observed in microglia in post-mortem striatum of sporadic PD patients.	Iron	122-126	synuclein alpha	Homo sapiens	72-87
28476637-3	2017	Using Nramp1-deficient macrophage (RAW264.7) and microglial (BV-2) cells as in-vitro models, iron exposure significantly reduced the degradation rate of the administered human alpha-synuclein oligomers, which can be restored by the expression of the wild-type, but not mutant (D543N), Nramp1.	Iron	93-97	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	6-12
28476637-3	2017	Using Nramp1-deficient macrophage (RAW264.7) and microglial (BV-2) cells as in-vitro models, iron exposure significantly reduced the degradation rate of the administered human alpha-synuclein oligomers, which can be restored by the expression of the wild-type, but not mutant (D543N), Nramp1.	Iron	93-97	synuclein alpha	Homo sapiens	176-191
28476637-4	2017	Likewise, under iron overload condition, mice with functional Nramp1 (DBA/2 and C57BL/6 congenic mice carrying functional Nramp1) had a better ability to degrade infused human alpha-synuclein oligomers than mice with nonfunctional Nramp1 (C57BL/6) in the brain and microglia.	Iron	16-20	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	62-68
28476637-4	2017	Likewise, under iron overload condition, mice with functional Nramp1 (DBA/2 and C57BL/6 congenic mice carrying functional Nramp1) had a better ability to degrade infused human alpha-synuclein oligomers than mice with nonfunctional Nramp1 (C57BL/6) in the brain and microglia.	Iron	16-20	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	122-128
28476637-4	2017	Likewise, under iron overload condition, mice with functional Nramp1 (DBA/2 and C57BL/6 congenic mice carrying functional Nramp1) had a better ability to degrade infused human alpha-synuclein oligomers than mice with nonfunctional Nramp1 (C57BL/6) in the brain and microglia.	Iron	16-20	synuclein alpha	Homo sapiens	176-191
28476637-4	2017	Likewise, under iron overload condition, mice with functional Nramp1 (DBA/2 and C57BL/6 congenic mice carrying functional Nramp1) had a better ability to degrade infused human alpha-synuclein oligomers than mice with nonfunctional Nramp1 (C57BL/6) in the brain and microglia.	Iron	16-20	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	122-128
28476637-5	2017	The interplay between iron and Nramp1 exhibited parallel effects on the clearance of alpha-synuclein and the activity of lysosomal cathepsin D in vitro and in vivo.	Iron	22-26	synuclein, alpha	Mus musculus	85-100
28476637-6	2017	Collectively, these findings suggest that the function of Nramp1 contributes to microglial degradation of oligomeric alpha-synuclein under iron overload condition and may be implicated in the pathogenesis of PD.	Iron	139-143	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	58-64
28476637-6	2017	Collectively, these findings suggest that the function of Nramp1 contributes to microglial degradation of oligomeric alpha-synuclein under iron overload condition and may be implicated in the pathogenesis of PD.	Iron	139-143	synuclein, alpha	Mus musculus	117-132
28627074-1	2017	A transition-metal-nitrogen/carbon (TM-N/C, TM = Fe, Co, Ni, etc.)	Iron	49-51	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	36-42
28754960-1	2017	In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	43-47
28754960-1	2017	In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	49-56
29212168-0	2017	Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells.	Iron	54-58	solute carrier family 40 member 1	Homo sapiens	79-86
29212168-2	2017	Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites.	Iron	50-54	solute carrier family 40 member 1	Homo sapiens	0-33
29212168-2	2017	Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites.	Iron	50-54	solute carrier family 40 member 1	Homo sapiens	35-42
29212168-8	2017	Overexpression of SLC40A1 was able to reverse cisplatin resistance induced by Nrf2, while knockdown of SLC40A1 restored cisplatin resistance and increased iron concentration.	Iron	155-159	solute carrier family 40 member 1	Homo sapiens	103-110
29212168-12	2017	Iron overload induced by SLC40A1 resulted in cisplatin resistance in ovarian cancer.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	25-32
28715425-0	2017	Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.	Iron	139-143	huntingtin	Mus musculus	15-25
28715425-7	2017	Here we show that elimination of Htt expression in the adult mouse results in behavioral deficits, progressive neuropathological changes including bilateral thalamic calcification, and altered brain iron homeostasis.	Iron	199-203	huntingtin	Mus musculus	33-36
28389358-5	2017	Furthermore, Fes was found to be involved in monocytic differentiation via upregulation of PU.1 and MCSFR and Fes siRNA could also inhibit 1,25D3-induced monocytic differentiation of U937 and HL60 cells and decrease mRNA expression of CD11c, CD18 and CD64.	Iron	13-16	Fc gamma receptor Ia	Homo sapiens	251-255
28737149-1	2017	Hepcidin is a key molecule involved in iron homeostasis.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
28704474-6	2017	In these animals the catalytic activity of heme oxygenase 1 contributed to the release of elemental iron from the protoporphyrin ring of heme within enterocytes, which may then be transported by the strongly expressed ferroportin across the basolateral membrane to the circulation.	Iron	100-104	heme oxygenase 1	Homo sapiens	43-59
28421266-6	2017	The results showed that iron overload could reduce the percentage of CD3+ T cells and the ratio of Th1/Th2 and Tc1/Tc2 but increase the percentage of regulatory T (Treg) cells and the ratio of CD4/CD8.	Iron	24-28	heart and neural crest derivatives expressed 2	Mus musculus	103-106
25201076-8	2015	Decreased levels of ferritin may lead to a strong deregulation of the expression of several metal transporter genes and over-accumulation of iron, which led to increased levels of reactive oxygen species, resulting to detoxification of these reactive species.	Iron	141-145	ferritin-1, chloroplastic	Glycine max	20-28
24954801-1	2015	Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger neurodegeneration through various mechanisms, notably induction of oxidative stress, promotion of alpha-synuclein aggregation and fibril formation, activation of microglial cells leading to inflammation and impaired production of metalloproteins.	Iron	61-63	synuclein alpha	Homo sapiens	181-196
28347842-2	2017	The enzyme heme oxygenase-1 (HO-1), involved in the degradation of heme, forms carbon monoxide (CO), ferrous iron, and bilirubin in conjunction with biliverdin reductase, and is induced by various stimuli including oxidative stress and heavy metals.	Iron	109-113	heme oxygenase 1	Homo sapiens	11-27
24954801-3	2015	In Parkinson"s disease local dysregulation of iron metabolism in the substantia nigra (SN) seems to be related to neurodegeneration with an increase in SN iron concentration, accompanied by decreased SN Cu and ceruloplasmin concentrations and increased free Cu concentrations and decreased ferroxidase activity in the cerebrospinal fluid.	Iron	46-50	ceruloplasmin	Homo sapiens	210-223
25368382-0	2015	The basic leucine zipper stress response regulator Yap5 senses high-iron conditions by coordination of [2Fe-2S] clusters.	Iron	68-72	Yap5p	Saccharomyces cerevisiae S288C	51-55
28347842-2	2017	The enzyme heme oxygenase-1 (HO-1), involved in the degradation of heme, forms carbon monoxide (CO), ferrous iron, and bilirubin in conjunction with biliverdin reductase, and is induced by various stimuli including oxidative stress and heavy metals.	Iron	109-113	heme oxygenase 1	Homo sapiens	29-33
25368382-3	2015	The Saccharomyces cerevisiae transcription factor Yap5, a member of the Yap family of bZIP stress response regulators, administrates the adaptive response to high-iron conditions.	Iron	163-167	Yap5p	Saccharomyces cerevisiae S288C	50-54
25368382-5	2015	Here, we show that Yap5 senses high-iron conditions by two Fe/S clusters bound to its activator domain (Yap5-AD).	Iron	36-40	Yap5p	Saccharomyces cerevisiae S288C	19-23
28347842-10	2017	GENERAL SIGNIFICANCE: The key role of heme metabolism in the stress-inducible expression of HO-1 may promote further studies on heme and its degradation products as protective factors of cellular stresses and iron homeostasis in specialized cells, organs, and whole animal systems.	Iron	209-213	heme oxygenase 1	Homo sapiens	92-96
25368382-5	2015	Here, we show that Yap5 senses high-iron conditions by two Fe/S clusters bound to its activator domain (Yap5-AD).	Iron	36-40	Yap5p	Saccharomyces cerevisiae S288C	104-108
25368382-6	2015	The more stable iron-regulatory Fe/S cluster at the N-terminal cysteine-rich domain (n-CRD) of Yap5 is detected in vivo and in vitro.	Iron	16-20	Yap5p	Saccharomyces cerevisiae S288C	95-99
27758046-1	2017	The concentration of hepcidin, a key regulator of iron metabolism, is suppressed during periods of increased erythropoietic activity.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	21-29
25564462-7	2015	We functionally confirmed iron-dependent depletion of HSP90 and its client proteins at pharmacologically achievable concentrations of CPX, and we extended this effect to piroctone, 8-hydroxyquinoline, and deferasirox.	Iron	26-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	54-59
28557419-0	2017	PEGylated GdF3:Fe Nanoparticles as Multimodal T1/T2-Weighted MRI and X-ray CT Imaging Contrast Agents.	Iron	15-17	growth differentiation factor 3	Homo sapiens	10-14
26304233-1	2015	BACKGROUND: Hepcidin, a key regulatory peptide hormone in iron homeostasis, may in future serve as a non-invasive iron status parameter for monitoring iron supplementation in preterm infants.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	12-20
26304233-1	2015	BACKGROUND: Hepcidin, a key regulatory peptide hormone in iron homeostasis, may in future serve as a non-invasive iron status parameter for monitoring iron supplementation in preterm infants.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	12-20
26304233-1	2015	BACKGROUND: Hepcidin, a key regulatory peptide hormone in iron homeostasis, may in future serve as a non-invasive iron status parameter for monitoring iron supplementation in preterm infants.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	12-20
28438835-1	2017	Hepcidin is a liver-derived hormone that negatively regulates serum iron levels and is mainly regulated at the transcriptional level.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
25579711-2	2015	Hepcidin is a polypeptide that regulates iron homeostasis and could serve as an indicator of functional iron deficiency in patients with end-stage renal disease (ESRD); this may also aid in the assessment of patient"s response to erythropoietin (EPO).	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
28747430-7	2017	Finally, we found that p53 played a role in iron homeostasis and was required for FDXR-mediated iron metabolism.	Iron	96-100	transformation related protein 53, pseudogene	Mus musculus	23-26
25551249-0	2014	Hepcidin-25, mean corpuscular volume, and ferritin as predictors of response to oral iron supplementation in hemodialysis patients.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	0-8
28747430-8	2017	Together, we conclude that FDXR and p53 are mutually regulated and that the FDXR-p53 loop is critical for tumor suppression via iron homeostasis.	Iron	128-132	transformation related protein 53, pseudogene	Mus musculus	36-39
25551249-11	2014	We conclude that hepcidin-25, MCV, and ferritin could be useful markers of iron storage status and may help predict OIT response in HD patients.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	17-25
28747430-8	2017	Together, we conclude that FDXR and p53 are mutually regulated and that the FDXR-p53 loop is critical for tumor suppression via iron homeostasis.	Iron	128-132	transformation related protein 53, pseudogene	Mus musculus	81-84
28409396-1	2017	PURPOSE: The extent to which hepcidin regulation after acute bouts of exercise is influenced by baseline (resting) concentrations of key iron parameters remains uncertain.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	29-37
25398878-0	2014	Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.	Iron	107-109	peroxiredoxin 3	Mus musculus	48-61
25398878-0	2014	Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.	Iron	107-109	peroxiredoxin 3	Mus musculus	62-66
25398878-0	2014	Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.	Iron	171-175	peroxiredoxin 3	Mus musculus	48-61
25398878-0	2014	Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.	Iron	171-175	peroxiredoxin 3	Mus musculus	62-66
28409396-7	2017	Significant individual relationships were evident between 3-h post-exercise hepcidin-25, baseline serum ferritin and serum iron (r &gt; 0.62; p &lt; 0.05).	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	76-84
25516512-2	2014	The mechanism involves not only hepcidin, the key hormone in iron metabolism, but also iron-related proteins and signaling-transduction molecules, such as IL-6 and signal transducer and activator of transcription 3 (Stat3).	Iron	87-91	signal transducer and activator of transcription 3	Rattus norvegicus	164-214
25516512-2	2014	The mechanism involves not only hepcidin, the key hormone in iron metabolism, but also iron-related proteins and signaling-transduction molecules, such as IL-6 and signal transducer and activator of transcription 3 (Stat3).	Iron	87-91	signal transducer and activator of transcription 3	Rattus norvegicus	216-221
28409396-8	2017	Multiple regression analysis showed that these two iron parameters, in addition to post-exercise IL-6 concentration and 25-km race-walk time, accounted for ~77% of the variance in 3-h post-exercise hepcidin-25 (p &lt; 0.01).	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	198-206
28409396-10	2017	CONCLUSION: Despite exercise activating numerous hepcidin regulators, baseline iron status appears to play a dominant role in the regulation of hepcidin-25 in elite-level athletes subsequent to endurance exercise.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	144-152
28294512-2	2017	Chronic inflammation indeed often causes an upregulation of the iron hormone hepcidin, thereby reducing iron absorption and availability to the erythron.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	77-85
26583221-2	2014	For a &gt;1000 atom model of the oxygenated myoglobin protein, the DDEC/c3 net charge of the adsorbed oxygen molecule is approximately -1e (in agreement with the Weiss model) using a dynamical mean field theory treatment of the iron atom, but much smaller in magnitude when using the generalized gradient approximation.	Iron	228-232	myoglobin	Homo sapiens	44-53
28294512-2	2017	Chronic inflammation indeed often causes an upregulation of the iron hormone hepcidin, thereby reducing iron absorption and availability to the erythron.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	77-85
28294512-4	2017	In this setting, mutations in the HFE gene of hereditary hemochromatosis may confer an adaptive benefit by decreasing hepcidin release, thus improving iron availability to erythropoiesis, anemia control, and the response to erythropoiesis stimulating agents and iron itself, and reducing the side effects of these therapies.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	118-126
28294512-4	2017	In this setting, mutations in the HFE gene of hereditary hemochromatosis may confer an adaptive benefit by decreasing hepcidin release, thus improving iron availability to erythropoiesis, anemia control, and the response to erythropoiesis stimulating agents and iron itself, and reducing the side effects of these therapies.	Iron	262-266	hepcidin antimicrobial peptide	Homo sapiens	118-126
25239763-4	2014	6-hydroxydopamine-induced enhanced ferrous iron influx via improper up-regulation of divalent metal transporter 1 with iron responsive element (DMT1+IRE) was consistently relieved by BDNF and GDNF.	Iron	43-47	solute carrier family 11 member 2	Homo sapiens	144-152
28294512-5	2017	The HFE protein together with Transferrin receptor-2 may also have a direct role on erythroid differentiation and iron uptake in erythroid cells.	Iron	114-118	transferrin receptor 2	Homo sapiens	30-52
25239763-4	2014	6-hydroxydopamine-induced enhanced ferrous iron influx via improper up-regulation of divalent metal transporter 1 with iron responsive element (DMT1+IRE) was consistently relieved by BDNF and GDNF.	Iron	119-123	solute carrier family 11 member 2	Homo sapiens	144-152
28294512-6	2017	In addition, other genetic determinants of iron status, such as variants in Matriptase-2 (TMPRSS6), have been shown to influence iron metabolism in chronic hemodialysis patients, most likely acting through hepcidin regulation.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	206-214
28294512-6	2017	In addition, other genetic determinants of iron status, such as variants in Matriptase-2 (TMPRSS6), have been shown to influence iron metabolism in chronic hemodialysis patients, most likely acting through hepcidin regulation.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	206-214
28328181-3	2017	Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL-6, lead to hepcidin-induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	131-139
25280951-0	2014	In vitro heme and non-heme iron capture from hemoglobin, myoglobin and ferritin by bovine lactoferrin and implications for suppression of reactive oxygen species in vivo.	Iron	27-31	lactotransferrin	Bos taurus	90-101
25280951-1	2014	Lactoferrin (Lf), present in colostrum and milk is a member of the transferrin family of iron-binding glyco-proteins, with stronger binding capacity to ferric iron than hemoglobin, myoglobin or transferrin.	Iron	89-93	lactotransferrin	Bos taurus	0-11
27494818-7	2017	Protein levels of phosphorylated-JNK were increased after Fe injection, and could be suppressed by minocycline treatment.	Iron	58-60	mitogen-activated protein kinase 8	Rattus norvegicus	33-36
25280951-1	2014	Lactoferrin (Lf), present in colostrum and milk is a member of the transferrin family of iron-binding glyco-proteins, with stronger binding capacity to ferric iron than hemoglobin, myoglobin or transferrin.	Iron	89-93	lactotransferrin	Bos taurus	13-15
25280951-2	2014	Unlike hemoglobin and myoglobin, iron-bound Lf is reasonably stable to gastric and duodenal digestive conditions.	Iron	33-37	lactotransferrin	Bos taurus	44-46
25280951-4	2014	We therefore hypothesized that bovine Lf could capture and thereby terminate the cycle of ROS production by heme iron.	Iron	113-117	lactotransferrin	Bos taurus	38-40
25280951-5	2014	The transfer of heme iron from either intact or digested forms of hemoglobin and myoglobin and from intact ferritin was demonstrated by in vitro methods, monitoring Fe-saturation status of Lf by changes in absorptivity at 465 nm.	Iron	21-25	lactotransferrin	Bos taurus	189-191
28424258-8	2017	Hepcidin was superior to hemoglobin and sTfR as an indicator of iron deficiency.Conclusions: In Gambian pregnant women, hepcidin appears to be a useful diagnostic test for iron deficiency and may enable the identification of cases for whom iron would be beneficial.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	120-128
24998898-1	2014	Hepcidin, a peptide hormone produced in the liver, decreases intestinal iron absorption and macrophage iron release via effects on ferroportin.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
24998898-1	2014	Hepcidin, a peptide hormone produced in the liver, decreases intestinal iron absorption and macrophage iron release via effects on ferroportin.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	0-8
24998898-3	2014	Hepcidin is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
28424258-9	2017	Hepcidin suppression in the second trimester suggests a window for optimal timing for antenatal iron interventions.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	0-8
25216685-5	2014	The iron chelators deferoxamine, deferiprone and deferasirox decrease both tartrate-resistant acid phosphatase and cathepsin K expression, as well as osteoclast activity.	Iron	4-8	cathepsin K	Homo sapiens	115-126
28446628-1	2017	Background: Ferritin and hepcidin are markers of iron status that typically increase during inflammation or infection.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	25-33
25606020-3	2014	Our data showed that C. neoformans Nfu1 localized in the mitochondria and influenced homeostasis of essential metals such as iron, copper and manganese.	Iron	125-129	NFU1 iron-sulfur cluster scaffold	Homo sapiens	35-39
25606020-4	2014	Marked growth defects were observed in the mutant lacking NFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans.	Iron	106-110	NFU1 iron-sulfur cluster scaffold	Homo sapiens	58-62
25606020-4	2014	Marked growth defects were observed in the mutant lacking NFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans.	Iron	106-110	NFU1 iron-sulfur cluster scaffold	Homo sapiens	98-102
28470295-0	2017	Hepcidin: a real-time biomarker of iron need.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
25433101-2	2014	Hepcidin is proposed as the main hormone responsible for the control of iron reserves in the body, given its ability to induce degradation of ferroportin.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
25433101-3	2014	The action of hepcidin on ferroportin leads to a decreased dietary iron absorption, as well as to a decrease in macrophages.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	14-22
25433101-4	2014	Several factors such as the iron status, the amount of dietary iron, the inflammation, the hypoxia, the testosterone and the physical exercise have been pointed out as affecting the synthesis of hepcidin.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	195-203
28470295-2	2017	Hepcidin is a hormone primarily produced in the liver that has been proposed as the "master regulator" of dietary uptake and iron metabolism, and has enormous potential to provide a "real time" indicator of body iron levels.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	0-8
25433101-4	2014	Several factors such as the iron status, the amount of dietary iron, the inflammation, the hypoxia, the testosterone and the physical exercise have been pointed out as affecting the synthesis of hepcidin.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	195-203
28470295-2	2017	Hepcidin is a hormone primarily produced in the liver that has been proposed as the "master regulator" of dietary uptake and iron metabolism, and has enormous potential to provide a "real time" indicator of body iron levels.	Iron	212-216	hepcidin antimicrobial peptide	Homo sapiens	0-8
28470295-3	2017	In this Minireview, the biochemical function of hepcidin in regulating iron levels will be discussed, with a specific focus on how hepcidin can aid in the assessment of iron stores and clinical diagnosis of iron deficiency, iron deficiency anaemia and other iron-related disorders.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	48-56
24724721-3	2014	Most genes involved in PS biosynthesis and secretion (HvNAS3, HvNAS4, HvNAS6, HvNAS7, HvNAAT-A, HvDMAS1 and HvTOM1) induced by Fe deprivation were also significantly upregulated in the presence of Cd under Fe sufficient conditions.	Iron	127-129	HvTOM1	Hordeum vulgare	108-114
28641612-0	2017	[Expression and Significance of HIF-1alpha in Erythropoiesis of Secondary Iron Overload Disease after Irradiation Damage].	Iron	74-78	hypoxia inducible factor 1, alpha subunit	Mus musculus	32-42
28485415-1	2017	The aim of this study was to establish the effect of a prebiotic mix on heme and non-heme iron (Fe) bioavailability in humans.	Iron	90-94	Mix paired-like homeobox	Homo sapiens	65-68
25240856-3	2014	Ind1, an iron-sulfur cluster protein involved in the maturation of respiratory complex and binds an Fe/S cluster via a conserved CXXC motif in a labile way.	Iron	100-102	NUBP iron-sulfur cluster assembly factor, mitochondrial	Homo sapiens	0-4
28485415-1	2017	The aim of this study was to establish the effect of a prebiotic mix on heme and non-heme iron (Fe) bioavailability in humans.	Iron	96-98	Mix paired-like homeobox	Homo sapiens	65-68
25501198-1	2014	Hepcidin is a key protein of iron metabolism, which may play an important role in the prognosis of patients with chronic renal failure on maintenance hemodialysis.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
28485415-9	2017	We concluded that daily consumption of a prebiotic mix increases heme Fe bioavailability and does not affect non-heme iron bioavailability.	Iron	70-72	Mix paired-like homeobox	Homo sapiens	51-54
28511672-12	2017	The mRNA levels of iron-responsive genes, such as CrNRAMP2, CrATX1, CrFTR1, and CrFEA1, were also remarkably reduced.	Iron	19-23	uncharacterized protein	Chlamydomonas reinhardtii	80-86
25151311-1	2014	Expression of hepcidin, a central regulator of systemic iron metabolism, is transcriptionally regulated by the bone morphogenetic protein (BMP) pathway.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	14-22
28492233-1	2017	Mammalian A-type proteins, ISCA1 and ISCA2, are evolutionarily conserved proteins involved in iron-sulfur cluster (Fe-S) biogenesis.	Iron	94-98	iron-sulfur cluster assembly 1	Mus musculus	27-32
25151311-1	2014	Expression of hepcidin, a central regulator of systemic iron metabolism, is transcriptionally regulated by the bone morphogenetic protein (BMP) pathway.	Iron	56-60	bone morphogenetic protein 1	Homo sapiens	111-137
25151311-1	2014	Expression of hepcidin, a central regulator of systemic iron metabolism, is transcriptionally regulated by the bone morphogenetic protein (BMP) pathway.	Iron	56-60	bone morphogenetic protein 1	Homo sapiens	139-142
28492233-1	2017	Mammalian A-type proteins, ISCA1 and ISCA2, are evolutionarily conserved proteins involved in iron-sulfur cluster (Fe-S) biogenesis.	Iron	115-119	iron-sulfur cluster assembly 1	Mus musculus	27-32
28492233-3	2017	Here we report that mouse ISCA1 and ISCA2 are Fe2S2-containing proteins that combine all features of Fe-S carrier proteins.	Iron	101-105	iron-sulfur cluster assembly 1	Mus musculus	26-31
25618111-1	2014	BACKGROUND: Lactoferrin belongs to the immunoregulatory milk proteins involved in iron metabolism as well in providing innate immunity to newborns.	Iron	82-86	lactotransferrin	Bos taurus	12-23
28453699-13	2017	Conclusion: The miRNA binding site SNP rs1062980 in iron regulatory pathway, which may alter the expression of IREB2 potentially through modulating the binding of miR-29a, together with dietary iron intake may modify risk of LC both individually and jointly.	Iron	52-56	microRNA 29a	Homo sapiens	163-170
28453699-13	2017	Conclusion: The miRNA binding site SNP rs1062980 in iron regulatory pathway, which may alter the expression of IREB2 potentially through modulating the binding of miR-29a, together with dietary iron intake may modify risk of LC both individually and jointly.	Iron	194-198	microRNA 29a	Homo sapiens	163-170
24341521-2	2014	The absence of ferroxidase activity caused by mutation of ceruloplasmin leads to iron overload in the brain, liver and other organs.	Iron	81-85	ceruloplasmin	Homo sapiens	58-71
28263291-0	2017	Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation.	Iron	0-4	erythropoietin	Mus musculus	16-30
25598789-0	2014	Association of hepcidin mRNA expression with hepatocyte iron accumulation and effects of antiviral therapy in chronic hepatitis C infection.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	15-23
25598789-2	2014	Hepcidin is a regulator of iron homeostasis and a component of innate immunity.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
28263291-0	2017	Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation.	Iron	0-4	endothelial PAS domain protein 1	Mus musculus	73-105
25598789-3	2014	Based on experimental studies, iron overload might be a result of low hepcidin synthesis in CHC.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	70-78
25598789-4	2014	OBJECTIVES: The aim of this case-control study was to assess hepcidin mRNA expression in liver tissue of patients with CHC in terms of iron metabolism parameters, hemochromatosis (HFE) gene mutations, disease activity, and efficacy of antiviral treatment with pegylated interferon and ribavirin.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	61-69
25598789-8	2014	In CHC group, hepcidin mRNA expression was positively correlated with alanine aminotransferase activity and serum iron concentration.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	14-22
28263291-3	2017	However, excess iron causes oxidative stress via the Fenton reaction, and iron supplementation might damage remnant renal function including erythropoietin (EPO) production in CKD.	Iron	74-78	erythropoietin	Mus musculus	141-155
28263291-3	2017	However, excess iron causes oxidative stress via the Fenton reaction, and iron supplementation might damage remnant renal function including erythropoietin (EPO) production in CKD.	Iron	74-78	erythropoietin	Mus musculus	157-160
25156943-1	2014	Iron-refractory iron-deficiency anemia (IRIDA) is a rare autosomal-recessive disorder characterized by hypochromic microcytic anemia, low transferrin saturation, and inappropriate high levels of the iron hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	212-220
28263291-4	2017	EPO gene expression was suppressed in mice following direct iron treatment.	Iron	60-64	erythropoietin	Mus musculus	0-3
25156943-1	2014	Iron-refractory iron-deficiency anemia (IRIDA) is a rare autosomal-recessive disorder characterized by hypochromic microcytic anemia, low transferrin saturation, and inappropriate high levels of the iron hormone hepcidin.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	212-220
28263291-5	2017	Hypoxia-inducible factor-2 alpha (HIF-2alpha), a positive regulator of the EPO gene, was also diminished in the kidney of mice following iron treatment.	Iron	137-141	endothelial PAS domain protein 1	Mus musculus	0-32
28263291-5	2017	Hypoxia-inducible factor-2 alpha (HIF-2alpha), a positive regulator of the EPO gene, was also diminished in the kidney of mice following iron treatment.	Iron	137-141	endothelial PAS domain protein 1	Mus musculus	34-44
28263291-5	2017	Hypoxia-inducible factor-2 alpha (HIF-2alpha), a positive regulator of the EPO gene, was also diminished in the kidney of mice following iron treatment.	Iron	137-141	erythropoietin	Mus musculus	75-78
25175370-8	2014	In addition, the inhibition of HO-1 activity with the iron chelator, desferrioxamine (DFO), or HO-1 siRNA increased cilostazol-induced chondrocyte senescence.	Iron	54-58	heme oxygenase 1	Homo sapiens	31-35
28263291-6	2017	Anemia-induced increase in renal EPO and HIF-2alpha expression was inhibited by iron treatment.	Iron	80-84	erythropoietin	Mus musculus	33-36
28263291-6	2017	Anemia-induced increase in renal EPO and HIF-2alpha expression was inhibited by iron treatment.	Iron	80-84	endothelial PAS domain protein 1	Mus musculus	41-51
28263291-7	2017	In in vitro experiments using EPO-producing HepG2 cells, iron stimulation reduced the expression of the EPO gene, as well as HIF-2alpha.	Iron	57-61	endothelial PAS domain protein 1	Homo sapiens	125-135
28263291-8	2017	Moreover, iron treatment augmented oxidative stress, and iron-induced reduction of EPO and HIF-2alpha expression was restored by tempol, an antioxidant compound.	Iron	57-61	erythropoietin	Mus musculus	83-86
24825446-2	2014	Hepcidin, a key mediator in this anemia, is up-regulated by high iron levels and inflammation, and serum levels are elevated in IBD.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	0-8
28263291-8	2017	Moreover, iron treatment augmented oxidative stress, and iron-induced reduction of EPO and HIF-2alpha expression was restored by tempol, an antioxidant compound.	Iron	57-61	endothelial PAS domain protein 1	Mus musculus	91-101
24825446-4	2014	This study aimed to evaluate serum hepcidin levels in anemic and non-anemic IBD patients, with iron or non-iron deficiency, and active or inactive disease.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	35-43
28263291-9	2017	HIF-2alpha interaction with the Epo promoter was inhibited by iron treatment, and was restored by tempol.	Iron	62-66	endothelial PAS domain protein 1	Mus musculus	0-10
28263291-9	2017	HIF-2alpha interaction with the Epo promoter was inhibited by iron treatment, and was restored by tempol.	Iron	62-66	erythropoietin	Mus musculus	32-35
28263291-10	2017	These findings suggested that iron supplementation reduced EPO gene expression via an oxidative stress-HIF-2alpha-dependent signaling pathway.	Iron	30-34	erythropoietin	Mus musculus	59-62
28263291-10	2017	These findings suggested that iron supplementation reduced EPO gene expression via an oxidative stress-HIF-2alpha-dependent signaling pathway.	Iron	30-34	endothelial PAS domain protein 1	Mus musculus	103-113
25189342-0	2014	A Cd/Fe/Zn-responsive phytochelatin synthase is constitutively present in the ancient liverwort Lunularia cruciata (L.) dumort.	Iron	5-7	phytochelatin synthase 1 (PCS1)	Arabidopsis thaliana	22-44
28236214-9	2017	Mutant Atx3 and alpha-Syn also potentiated altered redox status induced by iron and rotenone, a hint to how these proteins might influence neuronal dysfunction under pro-oxidant conditions.	Iron	75-79	synuclein alpha	Homo sapiens	16-25
25282486-5	2014	Hepcidin and ferroportin are the main proteins of iron regulation.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
25352340-4	2014	SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis.	Iron	35-39	transferrin receptor 2	Homo sapiens	23-27
25311416-2	2014	Astrocytes secrete a soluble form of ceruloplasmin (sCp) which, in turn, acts to export iron from ferroportin (Fpn) on the basolateral surface of BMVEC.	Iron	88-92	ceruloplasmin	Homo sapiens	37-50
25099276-5	2014	Tau and the amyloid protein precursor have important roles in normal neuronal iron homeostasis.	Iron	78-82	microtubule associated protein tau	Homo sapiens	0-3
25111396-3	2014	With iron(ii) halides and tert-butyl groups on the phenoxy ligands L2 and L3, the iron(iii) complexes [(L2)FeX2] {where X = Cl (3), Br (4) and I = (5)} and [(L3)FeCl2] (6) were formed.	Iron	82-86	stabilin 2	Homo sapiens	107-111
28584599-2	2017	The aim of this study was to determine the relationship between iron, ferritin, and hepcidin levels in diabetic patients and the effect of insulin treatment.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	84-92
28584599-11	2017	By correcting hepcidin levels, we can prevent cellular iron overload and reduce the risk of diabetes.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	14-22
28186648-1	2017	Heme oxygenase-1 (HO-1) catalyses the degradation of heme to biliverdin, free iron, and carbon monoxide.	Iron	78-82	heme oxygenase 1	Homo sapiens	0-16
24928110-3	2014	Lactoferrin, an iron binding protein found in milk, has been shown to inhibit bacterial adherence by direct interaction and disruption of bacterial surfaces.	Iron	16-20	lactotransferrin	Bos taurus	0-11
28186648-1	2017	Heme oxygenase-1 (HO-1) catalyses the degradation of heme to biliverdin, free iron, and carbon monoxide.	Iron	78-82	heme oxygenase 1	Homo sapiens	18-22
28491880-3	2017	This entity is caused by mutants of the TMPRSS6 gene that encodes the protein matriptase II, which influences hepcidin expression, an iron metabolism counterregulatory protein.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	110-118
25116229-0	2014	Serum hepcidin measured by immunochemical and mass-spectrometric methods and their correlation with iron status indicators in healthy children aged 0.5-3 y.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	6-14
25134646-0	2014	Impact of hepcidin antimicrobial peptide on iron overload in tuberculosis patients.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	10-18
28087880-2	2017	Here, we demonstrate that tripodal ligands (RC(CH2 OH)3 , R=NH2 , CH2 OH, or NHC2 H4 SO3 H) are useful as "one-size-fits-all" modifiers for the direct synthesis of hybrid metal hydroxide nanosheets with various constituent metallic elements (M=Mg, Mn, Fe, Co, Ni, or Cu) and surface functional groups.	Iron	252-254	NLR family pyrin domain containing 4	Homo sapiens	58-63
25134646-4	2014	In this study, we decided to identify -582A&gt; G variants of the HAMP promoter in patients with tuberculosis (TB) and investigate its effect on serum iron, ferritin, and hepcidin levels.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	66-70
25134646-11	2014	There was significant reverse correlation between hepcidin and iron (r = -0.849, p = 0.006).	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	50-58
24456328-1	2014	Inadequate iron availability limits the response to erythropoiesis-stimulating agents (ESA) and hepcidin is a key regulator of iron metabolism.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	96-104
24456328-2	2014	However, there is little information concerning time-dependent changes in hepcidin in response to the change of accelerated iron demand due to ESA-induced erythropoiesis.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	74-82
24456328-9	2014	Time course of iron-related parameters including hepcidin demonstrated accelerated iron utilization appropriately according to ESA-induced erythropoiesis.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	49-57
28380382-2	2017	Recent studies have shown that the co-chaperone HSC20, essential for Fe-S cluster biogenesis of SDHB, directly binds LYRM7, formerly described as a chaperone that stabilizes UQCRFS1 prior to its insertion into CIII.	Iron	69-73	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	48-53
24456328-9	2014	Time course of iron-related parameters including hepcidin demonstrated accelerated iron utilization appropriately according to ESA-induced erythropoiesis.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	49-57
28380382-3	2017	Here we report that a transient subcomplex involved in CIII assembly, composed of LYRM7 bound to UQCRFS1, interacts with components of an Fe-S transfer complex, consisting of HSC20, its cognate chaperone HSPA9, and the holo-scaffold ISCU.	Iron	138-140	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	175-180
25355252-5	2014	Compared with the control group, the serum HO-1 was significantly increased at 6, 12, 24, 48 h after the heart valve replacement surgery in both the RIPerC and RIPostC groups (P&lt;0.05); the SCr, BUN, urinary NGAL and serum iron values were decreased at 6, 12, 24, 48 h after the heart valve replacement surgery in both the RIPerC and RIPostC groups (P&gt;0.05).	Iron	225-229	heme oxygenase 1	Homo sapiens	43-47
28138741-4	2017	Hepcidin 1-25 is involved in iron-related disorders and anemia, in an inflammatory context, and its clinical relevance in neurodegenerative disorders is under investigation.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
25261367-0	2014	The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.	Iron	4-8	NDRG family member 2	Homo sapiens	74-107
25261367-0	2014	The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.	Iron	4-8	NDRG family member 2	Homo sapiens	109-114
25261367-0	2014	The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.	Iron	4-8	interleukin 6 cytokine family signal transducer	Homo sapiens	116-121
25261367-2	2014	The iron chelator Dp44mT up-regulated NDRG2, suppressed epithelial-mesenchymal transition (EMT) and inhibited tumor metastasis in HCC having high metastatic potential.	Iron	4-8	NDRG family member 2	Homo sapiens	38-43
25222239-2	2014	As a key protein for iron metabolism, hepcidin plays an important role in CRI anemia.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	38-46
24954650-7	2014	HO-1 metabolizes heme to biliverdin, iron and carbon monoxide (CO).	Iron	37-41	heme oxygenase 1	Homo sapiens	0-4
24951794-10	2014	We conclude that uptake of iron during biofilm formation triggers lambdaSo-mediated lysis of a subpopulation of cells, likely by an increase in iron-mediated DNA damage sensed by RecA.	Iron	27-31	recombinase RecA	Shewanella oneidensis MR-1	179-183
24951794-10	2014	We conclude that uptake of iron during biofilm formation triggers lambdaSo-mediated lysis of a subpopulation of cells, likely by an increase in iron-mediated DNA damage sensed by RecA.	Iron	144-148	recombinase RecA	Shewanella oneidensis MR-1	179-183
25120608-0	2014	Iron regulates the expression of ferroportin 1 in the cultured hFOB 1.19 osteoblast cell line.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	33-46
25120608-1	2014	Iron metabolism is tightly regulated in osteoblasts, and ferroportin 1 (FPN1) is the only identified iron exporter in mammals to date.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	57-70
25120608-1	2014	Iron metabolism is tightly regulated in osteoblasts, and ferroportin 1 (FPN1) is the only identified iron exporter in mammals to date.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	72-76
25120608-6	2014	The results demonstrated that increasing iron concentrations via FAC treatment increased the expression of FPN1.	Iron	41-45	solute carrier family 40 member 1	Homo sapiens	107-111
25120608-8	2014	In addition to demonstrating that the FNP1 expression changed according to the iron concentration, the observations indicated that changes in FPN1 expression may contribute to the maintenance of the intracellular iron balance in osteoblasts.	Iron	213-217	solute carrier family 40 member 1	Homo sapiens	142-146
24714983-1	2014	Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1).	Iron	49-53	solute carrier family 40 member 1	Homo sapiens	174-187
24714983-1	2014	Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1).	Iron	49-53	solute carrier family 40 member 1	Homo sapiens	189-196
24714983-1	2014	Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1).	Iron	151-155	solute carrier family 40 member 1	Homo sapiens	174-187
24714983-1	2014	Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1).	Iron	151-155	solute carrier family 40 member 1	Homo sapiens	189-196
25238834-11	2014	Hepcidin mRNA was increased with basal and high iron concentration.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-8
25040737-1	2014	INTRODUCTION: Hepcidin, a small peptide hormone synthesized in the liver, plays central role in regulation of iron metabolism.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	14-22
25040737-2	2014	Hepcidin generation in chronic kidney disease (CKD) is dependent on iron status, anemia, inflammation, and hypoxia and erythropoietin levels.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
25193892-1	2014	Hepcidin may play a critical role in the response of patients with anemia to iron and erythropoiesis-stimulating agent therapy.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
24875174-3	2014	Lactoferrin is an 80-kDa iron-binding glycoprotein with various biological activities, including iron-chelating ability.	Iron	25-29	lactotransferrin	Bos taurus	0-11
24904118-2	2014	HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	46-54
24904118-2	2014	HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	46-54
25092293-2	2014	The liver-produced hormone hepcidin dictates systemic iron homeostasis.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	27-35
24854545-8	2014	Iron-associated DMT1 could interact with PCBP2 in vitro, whereas iron-chelated DMT1 could not.	Iron	65-69	solute carrier family 11 member 2	Homo sapiens	79-83
24939758-4	2014	The computational study of 3i suggested that the major interactions between 3i and IDO protein are the coordination of sulfone and heme iron, the hydrogen bonding and hydrophobic interactions between 3i and IDO.	Iron	136-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	83-86
24875397-0	2014	Study of circulating hepcidin in association with iron excess, metabolic syndrome, and BMP-6 expression in granulosa cells in women with polycystic ovary syndrome.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	21-29
24875397-8	2014	Circulating hepcidin correlated with iron parameters, androgen index, hs-CRP, and fasting glucose and insulin levels, and with iron and ferritin levels after multiple regression analysis.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	12-20
24875397-8	2014	Circulating hepcidin correlated with iron parameters, androgen index, hs-CRP, and fasting glucose and insulin levels, and with iron and ferritin levels after multiple regression analysis.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	12-20
24330102-12	2014	As the expression of ferritin, a gene that encodes for an iron storage protein, is induced by free iron, these results suggest that S. sclerotiorum benefits from the ability of OA to free iron from plant proteins, as this induces host cell death, and also allows the uptake and assimilation of the iron for its own metabolic needs.	Iron	58-62	ferritin-1, chloroplastic	Glycine max	21-29
24330102-12	2014	As the expression of ferritin, a gene that encodes for an iron storage protein, is induced by free iron, these results suggest that S. sclerotiorum benefits from the ability of OA to free iron from plant proteins, as this induces host cell death, and also allows the uptake and assimilation of the iron for its own metabolic needs.	Iron	99-103	ferritin-1, chloroplastic	Glycine max	21-29
24330102-12	2014	As the expression of ferritin, a gene that encodes for an iron storage protein, is induced by free iron, these results suggest that S. sclerotiorum benefits from the ability of OA to free iron from plant proteins, as this induces host cell death, and also allows the uptake and assimilation of the iron for its own metabolic needs.	Iron	99-103	ferritin-1, chloroplastic	Glycine max	21-29
24330102-12	2014	As the expression of ferritin, a gene that encodes for an iron storage protein, is induced by free iron, these results suggest that S. sclerotiorum benefits from the ability of OA to free iron from plant proteins, as this induces host cell death, and also allows the uptake and assimilation of the iron for its own metabolic needs.	Iron	99-103	ferritin-1, chloroplastic	Glycine max	21-29
24914735-0	2014	Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)3 and NaBH4.	Iron	0-4	POU class 5 homeobox 1	Homo sapiens	79-84
25120486-6	2014	Thus, IRP1 emerged as a key regulator of erythropoiesis and iron absorption by controlling hypoxia inducible factor 2alpha (HIF2alpha) mRNA translation, while IRP2 appears to dominate the control of iron uptake and heme biosynthesis in erythroid progenitor cells by regulating the expression of transferrin receptor 1 (TfR1) and 5-aminolevulinic acid synthase 2 (ALAS2) mRNAs, respectively.	Iron	60-64	endothelial PAS domain protein 1	Mus musculus	91-122
25120486-6	2014	Thus, IRP1 emerged as a key regulator of erythropoiesis and iron absorption by controlling hypoxia inducible factor 2alpha (HIF2alpha) mRNA translation, while IRP2 appears to dominate the control of iron uptake and heme biosynthesis in erythroid progenitor cells by regulating the expression of transferrin receptor 1 (TfR1) and 5-aminolevulinic acid synthase 2 (ALAS2) mRNAs, respectively.	Iron	60-64	endothelial PAS domain protein 1	Mus musculus	124-133
24876565-2	2014	Iron absorption, plasma iron concentrations, and tissue iron distribution are tightly controlled by the liver-produced hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	127-135
24876565-2	2014	Iron absorption, plasma iron concentrations, and tissue iron distribution are tightly controlled by the liver-produced hormone hepcidin.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	127-135
24876565-2	2014	Iron absorption, plasma iron concentrations, and tissue iron distribution are tightly controlled by the liver-produced hormone hepcidin.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	127-135
24876565-3	2014	During the last decade, much progress has been made in elucidating hepcidin regulation by iron and inflammation.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	67-75
27660075-1	2017	Hepcidin synthesis is reported to be inadequate according to the body iron store in patients with non-alcoholic fatty liver disease (NAFLD) undergoing hepatic iron overload (HIO).	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
24858687-1	2014	Multiple-scattering (MS) analysis of EXAFS data on met-indoleamine 2,3-dioxygenase-2 (IDO2) and analysis of XANES have provided the first direct structural information about the axial donor ligands of the iron center for this recently discovered protein.	Iron	205-209	indoleamine 2,3-dioxygenase 2	Homo sapiens	51-84
24904115-4	2014	During these periods, efficient iron mobilization is ensured by the downregulation of the iron regulatory hormone hepcidin by as-yet uncharacterized molecular mechanisms.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	114-122
27660075-1	2017	Hepcidin synthesis is reported to be inadequate according to the body iron store in patients with non-alcoholic fatty liver disease (NAFLD) undergoing hepatic iron overload (HIO).	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	0-8
28346059-5	2017	UGT1A1 rs887829TT (p = 0.002) and CYP1A2 rs762551CC (p = 0.019) resulted as predictive factor of ferritin levels and CYP1A1 rs2606345CA/AA (p = 0.021) and CYP1A2 rs762551AC/CC (p = 0.027) of liver iron concentration.	Iron	197-201	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	34-40
24599423-10	2014	In conclusion, local iron retention and altered iron recycling associated to high hepcidin and low transferrin systemic concentrations could lead to reduced circulating haemoglobin levels in AAA patients.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	82-90
24599423-10	2014	In conclusion, local iron retention and altered iron recycling associated to high hepcidin and low transferrin systemic concentrations could lead to reduced circulating haemoglobin levels in AAA patients.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	82-90
25117103-1	2014	Mutations of the HAMP gene and HFE gene have a role in iron overload.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	17-21
28250070-0	2017	Mitochondrial ABC Transporter ATM3 Is Essential for Cytosolic Iron-Sulfur Cluster Assembly.	Iron	62-66	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	30-34
24505080-1	2014	Divalent metal ion transporter 1 (DMT1) is a proton-coupled Fe(2+)transporter that is essential for iron uptake in enterocytes and for transferrin-associated endosomal iron transport in many other cell types.	Iron	100-104	solute carrier family 11 member 2	Homo sapiens	34-38
24505080-1	2014	Divalent metal ion transporter 1 (DMT1) is a proton-coupled Fe(2+)transporter that is essential for iron uptake in enterocytes and for transferrin-associated endosomal iron transport in many other cell types.	Iron	168-172	solute carrier family 11 member 2	Homo sapiens	34-38
28250070-3	2017	This study reports that the ATM3 is required for cytosolic iron-sulfur cluster assembly and is essential for meristem maintenance in rice (Oryza sativa).	Iron	59-63	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	28-32
24777537-8	2014	As LIAS is an iron-sulphur-cluster-dependent enzyme, a number of recently identified defects in mitochondrial iron-sulphur cluster synthesis, including NFU1, BOLA3, IBA57, GLRX5 presented with deficiency of LIAS and a LIAS-like phenotype.	Iron	14-18	lipoic acid synthetase	Homo sapiens	3-7
28250070-12	2017	Our results suggest that the mitochondrial ATM3 is essential for iron homeostasis in rice.	Iron	65-69	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	43-47
28315258-4	2017	In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively.	Iron	89-93	Yap5p	Saccharomyces cerevisiae S288C	75-79
24807146-1	2014	Two new isostructural iron(II) spin-crossover (SCO) framework (SCOF) materials of the type [Fe(dpms)2(NCX)2] (dpms = 4,4"-dipyridylmethyl sulfide; X = S (SCOF-6(S)), X = Se (SCOF-6(Se))) have been synthesized.	Iron	22-26	solute carrier family 8 member A2	Homo sapiens	102-107
28315258-4	2017	In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively.	Iron	133-137	Yap5p	Saccharomyces cerevisiae S288C	75-79
28327200-8	2017	CONCLUSIONS: Our findings indicate that LY2787106 was well tolerated in cancer patients with anemia and that targeting the hepcidin-ferroportin pathway by neutralizing hepcidin resulted in transient iron mobilization, thus supporting the role of hepcidin in iron regulation.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	123-131
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	48-52	deoxyhypusine hydroxylase	Homo sapiens	56-81
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	48-52	deoxyhypusine hydroxylase	Homo sapiens	83-87
28327200-8	2017	CONCLUSIONS: Our findings indicate that LY2787106 was well tolerated in cancer patients with anemia and that targeting the hepcidin-ferroportin pathway by neutralizing hepcidin resulted in transient iron mobilization, thus supporting the role of hepcidin in iron regulation.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	168-176
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	104-108	deoxyhypusine hydroxylase	Homo sapiens	56-81
24843120-3	2014	Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.	Iron	104-108	deoxyhypusine hydroxylase	Homo sapiens	83-87
28327200-8	2017	CONCLUSIONS: Our findings indicate that LY2787106 was well tolerated in cancer patients with anemia and that targeting the hepcidin-ferroportin pathway by neutralizing hepcidin resulted in transient iron mobilization, thus supporting the role of hepcidin in iron regulation.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	168-176
24843120-6	2014	PCBP1 bound to DOHH in iron-treated cells but not in control or iron-deficient cells.	Iron	23-27	deoxyhypusine hydroxylase	Homo sapiens	15-19
28327200-8	2017	CONCLUSIONS: Our findings indicate that LY2787106 was well tolerated in cancer patients with anemia and that targeting the hepcidin-ferroportin pathway by neutralizing hepcidin resulted in transient iron mobilization, thus supporting the role of hepcidin in iron regulation.	Iron	258-262	hepcidin antimicrobial peptide	Homo sapiens	123-131
28296633-0	2017	The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.	Iron	133-137	transmembrane protein 199	Homo sapiens	50-57
24418516-16	2014	GENERAL SIGNIFICANCE: Ceruloplasmin is a go-between dietary or recycled Fe(2+) and transferrin transported Fe(3+).	Iron	72-74	ceruloplasmin	Homo sapiens	22-35
24418516-16	2014	GENERAL SIGNIFICANCE: Ceruloplasmin is a go-between dietary or recycled Fe(2+) and transferrin transported Fe(3+).	Iron	107-109	ceruloplasmin	Homo sapiens	22-35
28296633-0	2017	The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.	Iron	133-137	coiled-coil domain containing 115	Homo sapiens	62-69
25076763-0	2014	Hepcidin profile of anemic adolescent schoolgirls in Indonesia at the end of 12 weeks of iron supplementation.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
28130443-11	2017	We propose that NHE9 regulates TfR-dependent, recycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH in response to paracrine signals and is therefore an important regulator in iron mobilization pathway at the BBB.	Iron	68-72	solute carrier family 9 member A9	Homo sapiens	16-20
25076763-2	2014	Hepcidin, a newly discovered iron regulatory hormone, is an acute phase protein, and its role in iron supplementation has not been well explored.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
25076763-3	2014	OBJECTIVE: To investigate the hepcidin profiles of anemic adolescent girls who had received weekly iron supplementation.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	30-38
25076763-12	2014	However, hepcidin concentration was slightly higher in the iron replete-group than in the iron-deficient group (45.2 +/- 20.0 and 39.3 +/- 13.5 ng/mL, respectively), a suggestive trend that did not reach statistical significance (p = .218).	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	9-17
28130443-11	2017	We propose that NHE9 regulates TfR-dependent, recycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH in response to paracrine signals and is therefore an important regulator in iron mobilization pathway at the BBB.	Iron	199-203	solute carrier family 9 member A9	Homo sapiens	16-20
28224156-13	2017	The results of the present study demonstrate the utility of HL1, HL2 and H2L3 in the stabilisation of robust iron(iii)/oxido/alkoxido clusters.	Iron	109-113	intelectin 1	Homo sapiens	60-63
24662464-1	2014	The electrostatic surface of cytochrome c and its changes with the iron oxidation state are involved in the docking and undocking processes of this protein to its biological partners in the mitochondrial respiratory pathway.	Iron	67-71	cytochrome c, somatic	Equus caballus	29-41
28073521-1	2017	Hepcidin is the main regulator of iron metabolism and a pathogenic factor in iron disorders.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
28073521-2	2017	Hepcidin deficiency causes iron overload, whereas hepcidin excess causes or contributes to the development of iron-restricted anaemia in chronic inflammatory diseases.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
28073521-2	2017	Hepcidin deficiency causes iron overload, whereas hepcidin excess causes or contributes to the development of iron-restricted anaemia in chronic inflammatory diseases.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	50-58
28257520-5	2017	The formation of a 1:1 complex of iron-loaded Lf and LbpB involves an interaction between the Lf C-lobe and LbpB N-lobe, comparable to TbpB, consistent with a potential role in iron acquisition.	Iron	34-38	HLF transcription factor, PAR bZIP family member	Homo sapiens	46-48
28257520-5	2017	The formation of a 1:1 complex of iron-loaded Lf and LbpB involves an interaction between the Lf C-lobe and LbpB N-lobe, comparable to TbpB, consistent with a potential role in iron acquisition.	Iron	34-38	HLF transcription factor, PAR bZIP family member	Homo sapiens	94-96
28257520-5	2017	The formation of a 1:1 complex of iron-loaded Lf and LbpB involves an interaction between the Lf C-lobe and LbpB N-lobe, comparable to TbpB, consistent with a potential role in iron acquisition.	Iron	177-181	HLF transcription factor, PAR bZIP family member	Homo sapiens	46-48
28257520-7	2017	Our results are consistent with LbpB serving dual roles focused primarily on iron acquisition when exposed to limited levels of iron-loaded Lf on the mucosal surface and effectively binding apo Lf when exposed to high levels at sites of inflammation.	Iron	128-132	HLF transcription factor, PAR bZIP family member	Homo sapiens	140-142
28082120-2	2017	Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin.	Iron	167-171	heme oxygenase 1	Homo sapiens	30-34
27424009-8	2017	The effects caused by iron (500 microM) were mostly independent of alpha-syn expression and triggered different antioxidant responses to possibly counterbalance higher levels of free radicals.	Iron	22-26	synuclein alpha	Homo sapiens	67-76
28229619-1	2017	AIM: Hepcidin-25 is the master regulator of iron homeostasis.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	5-13
28452291-4	2017	Hb repletion study was carried out in Fe-deficient CD1 mice that were fed for 10 d a diet supplemented with ferrous IMAAC or FeSO4.	Iron	38-40	CD1 antigen complex	Mus musculus	51-54
27400857-7	2017	In neuronal cultures lithium attenuates iron efflux by lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux.	Iron	130-134	amyloid beta (A4) precursor protein	Mus musculus	90-115
28955733-4	2017	We have demonstrated that PBR-Associated Protein 7 (PAP7) bound to the Iron Responsive Element (IRE) isoform of divalent metal transporter 1 (DMT1).	Iron	71-75	solute carrier family 11 member 2	Homo sapiens	112-140
28955733-4	2017	We have demonstrated that PBR-Associated Protein 7 (PAP7) bound to the Iron Responsive Element (IRE) isoform of divalent metal transporter 1 (DMT1).	Iron	71-75	solute carrier family 11 member 2	Homo sapiens	142-146
28031261-8	2017	Our results demonstrate that ceruloplasmin decreases the bioavailability of iron in urine by a transferrin-dependent mechanism.	Iron	76-80	ceruloplasmin	Homo sapiens	29-42
28067386-2	2017	Although the pathogenesis of this problem is multifactorial, a key component is the abnormal elevation of the hormone hepcidin, the central regulator of systemic iron homeostasis.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	118-126
28067386-3	2017	Investigations over the last decade have resulted in important insights into the role of hepcidin in iron metabolism and the mechanisms that lead to hepcidin dysregulation in the context of inflammation.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	89-97
28286582-2	2017	Different concentrations of functional groups do not affect the size (3-5 nm) of Fe particles in the fresh catalysts but iron (carbide) supported on N-enriched CMK-3 and a support with a lower concentration of functional groups show higher catalytic activity under industrially relevant FTO conditions (340  C, 10 bar, H2/CO=2) compared to a support with an O-enriched surface.	Iron	121-125	complement C2	Homo sapiens	322-326
28106476-1	2017	AIM: Hepcidin, the main iron metabolism regulator, can be detected in various biological fluids.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	5-13
28129511-1	2017	Lactoferrin (Lf), an iron-chelating glycoprotein of innate immunity, produced by exocrine glands and neutrophils in infection/inflammation sites, is one of the most abundant defence molecules in airway secretions.	Iron	21-25	lactotransferrin	Mus musculus	0-11
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	79-83	lactotransferrin	Mus musculus	223-234
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	79-83	lactotransferrin	Mus musculus	236-238
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	lactotransferrin	Mus musculus	223-234
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	lactotransferrin	Mus musculus	236-238
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	lactotransferrin	Mus musculus	223-234
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	lactotransferrin	Mus musculus	236-238
28088947-1	2017	Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases.	Iron	88-92	heme oxygenase 1	Homo sapiens	16-20
28245299-10	2017	Conclusions: Vitreous humor may significantly limit iron uptake by transferrin/transferrin receptor pathway, and by increasing ferritin levels could profoundly increase the iron-storage capacity of ferritin in lens cells.	Iron	52-56	inhibitor of carbonic anhydrase	Canis lupus familiaris	67-78
28245299-10	2017	Conclusions: Vitreous humor may significantly limit iron uptake by transferrin/transferrin receptor pathway, and by increasing ferritin levels could profoundly increase the iron-storage capacity of ferritin in lens cells.	Iron	52-56	inhibitor of carbonic anhydrase	Canis lupus familiaris	79-90
27416847-1	2017	Objective Hepcidin regulates iron availability and may be responsible for the anemia of chronic disease because it is induced by interleukin-6.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	10-18
27980120-1	2017	Hepcidin is a liver-synthesized hormone that plays a central role in the regulation of systemic iron homeostasis.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	0-8
24119290-1	2014	Hepcidin has emerged as a peptide with a key role in the regulation of iron homeostasis in patients with chronic kidney disease (CKD), having a strong dependence on inflammation.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
27864295-0	2017	Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.	Iron	68-72	bone morphogenetic protein 6	Mus musculus	26-54
24910614-11	2014	Key to understanding the pathophysiology of iron metabolism in malaria is the activity of the iron regulatory hormone hepcidin.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	118-126
24910614-11	2014	Key to understanding the pathophysiology of iron metabolism in malaria is the activity of the iron regulatory hormone hepcidin.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	118-126
24910614-12	2014	Hepcidin is upregulated during blood-stage parasitemia and likely mediates much of the iron redistribution that accompanies disease.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
27864295-1	2017	Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance.	Iron	107-111	bone morphogenetic protein 6	Mus musculus	0-28
27864295-1	2017	Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance.	Iron	107-111	bone morphogenetic protein 6	Mus musculus	30-34
24596418-7	2014	More prevalent ID and lower hepcidin likely reflect an enhanced requirement for iron and an ability to efficiently absorb it at the end of the malaria season.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	28-36
28120861-5	2017	CNT exposure activates an oxidative stress-dependent production of iron via Nrf2 nuclear translocation, Ferritin H and Heme oxygenase 1 translation.	Iron	67-71	heme oxygenase 1	Homo sapiens	119-135
24626108-7	2014	Hepcidin is a 25-aa peptide, present in human serum and urine and represents the key peptide hormone, which modulates iron homeostasis in the body.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	0-8
28377980-10	2017	In summary, FGF23 can be driven by ectopic HIF1alpha activation under normal iron conditions in vitro, but factors independent of HIF1alpha activity after mature osteoblast formation are responsible for the disease phenotypes in Hyp mice in vivo.	Iron	77-81	hypoxia inducible factor 1, alpha subunit	Mus musculus	43-52
24872837-2	2014	Hepcidin, a liver peptide hormone, acts as the primary regulator of systemic iron status by blocking iron release from enterocytes into plasma.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
24872837-2	2014	Hepcidin, a liver peptide hormone, acts as the primary regulator of systemic iron status by blocking iron release from enterocytes into plasma.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	0-8
28054602-0	2017	Identification of Guanosine 5"-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	87-95
24872837-14	2014	Presence of adenocarcinoma iron accumulation was associated with higher serum hepcidin (iron accumulation group 80.8 vs iron absence group 22.0 ng/mL, p &lt; 0.05).	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	78-86
24872837-14	2014	Presence of adenocarcinoma iron accumulation was associated with higher serum hepcidin (iron accumulation group 80.8 vs iron absence group 22.0 ng/mL, p &lt; 0.05).	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	78-86
24872837-16	2014	Inappropriately elevated serum hepcidin may reduce duodenal iron absorption and further increase colonic adenocarcinoma iron exposure.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	31-39
24872837-16	2014	Inappropriately elevated serum hepcidin may reduce duodenal iron absorption and further increase colonic adenocarcinoma iron exposure.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	31-39
28054602-1	2017	Hepcidin, a peptide hormone, is a key regulator in mammalian iron homeostasis.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
24807559-7	2014	Modeling showed that this sensitivity of hepcidin expression at the population level could potentially enable simple groupings of individuals with anemia into iron-responsive and non-iron-responsive subtypes and hence could guide iron supplementation for those who would most benefit.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	41-49
28054602-2	2017	Increased level of hepcidin due to inflammatory conditions stimulates the ferroportin (FPN) transporter internalization, impairing the iron absorption; clinically manifested as anemia of inflammation (AI).	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	19-27
24807559-7	2014	Modeling showed that this sensitivity of hepcidin expression at the population level could potentially enable simple groupings of individuals with anemia into iron-responsive and non-iron-responsive subtypes and hence could guide iron supplementation for those who would most benefit.	Iron	183-187	hepcidin antimicrobial peptide	Homo sapiens	41-49
24807559-7	2014	Modeling showed that this sensitivity of hepcidin expression at the population level could potentially enable simple groupings of individuals with anemia into iron-responsive and non-iron-responsive subtypes and hence could guide iron supplementation for those who would most benefit.	Iron	183-187	hepcidin antimicrobial peptide	Homo sapiens	41-49
28054602-10	2017	These results suggest that GDP a promising natural small-molecule inhibitor that targets Hepcidin-FPN complex may be incorporated with iron supplement regimens to ameliorate AI.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	89-97
28450652-1	2017	AIM: to evaluate the correlation and the concordance between reticulocyte hemoglobin equivalent (RET-He) and reticulocyte hemoglobin content (CHr) as well as to obtain the cut-off value of RET-He as the target of iron supplementation in chronic kidney disease (CKD) patients undergoing hemodialysis.	Iron	213-217	ret proto-oncogene	Homo sapiens	189-192
24800994-0	2014	Effects of additional iron doses on hepcidin-25 level in hemodialysis patients without evident iron deficiency.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	36-44
24800994-1	2014	BACKGROUND: Serum hepcidin-25 is not only a marker of iron stores, but also an acute phase reactant, and it could fluctuate in response to erythropoietic activity.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	18-26
27955815-2	2017	C57BL/6J mice are extremely susceptible to systemic infection by Salmonella Typhimurium because of loss-of-function mutations in Nramp1 (SLC11A1), a phagosomal membrane protein that controls iron export from vacuoles and inhibits Salmonella growth in macrophages.	Iron	191-195	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	129-135
24800994-2	2014	STUDY DESIGN: Prospective interventional, 3-months duration, investigating the influence of additional intravenous (IV) iron on hepcidin-25 in hemodialysis (HD) patients without obvious iron deficiency (ID).	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	128-136
24800994-11	2014	After 75 % augmentation in iron doses, hepcidin-25 decreased by 70 %.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	39-47
24800994-18	2014	CONCLUSIONS: Activation of erythropoiesis by additional IV iron administration overcomes moderate inflammation in suppressing hepcidin-25.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	126-134
24800994-19	2014	Thus, hepcidin-25 could be clinically useful to evaluate iron status in patients with renal anemia.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	6-14
24581673-6	2014	Moreover, PHD2 inhibitors may increase the endogenous circulating iron availability via suppression of hepcidin, a master regulator of iron homeostasis which further reduces the need for exogenous intravenous iron administration for effective erythropoiesis in renal anemia patients.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	103-111
24581673-6	2014	Moreover, PHD2 inhibitors may increase the endogenous circulating iron availability via suppression of hepcidin, a master regulator of iron homeostasis which further reduces the need for exogenous intravenous iron administration for effective erythropoiesis in renal anemia patients.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	103-111
24581673-6	2014	Moreover, PHD2 inhibitors may increase the endogenous circulating iron availability via suppression of hepcidin, a master regulator of iron homeostasis which further reduces the need for exogenous intravenous iron administration for effective erythropoiesis in renal anemia patients.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	103-111
28329745-1	2017	BACKGROUND: In the past, elevated estradiol levels were reported to downregulate the iron regulatory hormone hepcidin, thereby potentially improving iron metabolism.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	109-117
24733891-7	2014	Together, these findings provide insight into RNR cofactor formation and reveal a shared mechanism underlying assembly of the Fe(III)2-Y  cofactor in RNR and the Fe-S clusters in cytosolic and nuclear proteins.	Iron	162-166	nuclear receptor subfamily 2 group E member 3	Homo sapiens	46-49
28329745-1	2017	BACKGROUND: In the past, elevated estradiol levels were reported to downregulate the iron regulatory hormone hepcidin, thereby potentially improving iron metabolism.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	109-117
24733926-4	2014	In mitochondria monothiol glutaredoxin 5 (GRX5) is involved in the maturation of all cellular Fe/S proteins and participates in cellular iron regulation.	Iron	137-141	glutaredoxin 5	Homo sapiens	16-40
27917462-2	2017	Increased iron absorption, driven by hepcidin suppression secondary to erythron expansion, initially causes intrahepatic iron overload.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	37-45
24733926-4	2014	In mitochondria monothiol glutaredoxin 5 (GRX5) is involved in the maturation of all cellular Fe/S proteins and participates in cellular iron regulation.	Iron	137-141	glutaredoxin 5	Homo sapiens	42-46
24678690-0	2014	Four-fold channels are involved in iron diffusion into the inner cavity of plant ferritin.	Iron	35-39	ferritin-1, chloroplastic	Glycine max	81-89
24678690-5	2014	Stopped-flow, electrode oximetry, and transmission electron microscopy (TEM) results showed that H193A/H197A and E165I/E167A/E171A exhibited a similar catalyzing activity of iron oxidation with each other, but a pronounced low activity compared to rH-2, demonstrating that both the 4-fold and 3-fold hydrophilic channels are necessary for iron diffusion in ferritin, followed by oxidation.	Iron	174-178	ferritin-1, chloroplastic	Glycine max	357-365
27917462-2	2017	Increased iron absorption, driven by hepcidin suppression secondary to erythron expansion, initially causes intrahepatic iron overload.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	37-45
28191453-4	2017	Hepcidin is the master inducer of iron accumulation during ACD, and its production is mainly regulated by IL-6 and the novel erythroid hormone erythroferrone (ERFE).	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
24607334-10	2014	Cp would accelerate iron export from the brain via the blood-cerebrospinal fluid (CSF) barrier, or CSF-brain barrier when excessive iron is loaded into the subarachnoid space.	Iron	20-24	ceruloplasmin	Homo sapiens	0-2
28191453-5	2017	This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin production and the levels of its main regulators, leading to a restoration of iron homeostasis.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	78-86
24607334-10	2014	Cp would accelerate iron export from the brain via the blood-cerebrospinal fluid (CSF) barrier, or CSF-brain barrier when excessive iron is loaded into the subarachnoid space.	Iron	132-136	ceruloplasmin	Homo sapiens	0-2
28424751-3	2017	The excess iron promotes Parkin and alpha-synuclein aggregation in the neurons.	Iron	11-15	synuclein alpha	Homo sapiens	36-51
28302014-3	2017	Hepcidin-25 (hepcidin) has emerged as a molecule that regulates iron metabolism.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-11
24124891-5	2014	While heme catabolism by heme oxygenase-1 (HO-1) prevents programmed cell death, this cytoprotective effect requires the co-expression of ferritin H (heart/heavy) chain (FTH), which controls the pro-oxidant effect of labile Fe released from the protoporphyrin IX ring of heme.	Iron	224-226	ferritin heavy chain 1	Homo sapiens	170-173
24124891-6	2014	This antioxidant effect of FTH restrains JNK activation, whereas JNK activation inhibits FTH expression, a cross talk that controls metabolic adaptation to cellular Fe overload associated with systemic infections.	Iron	165-167	ferritin heavy chain 1	Homo sapiens	27-30
24124891-7	2014	CRITICAL ISSUES AND FUTURE DIRECTIONS: Identification and characterization of the mechanisms via which FTH provides metabolic adaptation to tissue Fe overload should provide valuable information to our current understanding of the pathogenesis of systemic infections as well as other immune-mediated inflammatory diseases.	Iron	147-149	ferritin heavy chain 1	Homo sapiens	103-106
24131232-1	2014	SIGNIFICANCE: Heme oxygenases (HO-1 and HO-2) catalyze the degradation of the pro-oxidant heme into carbon monoxide (CO), iron, and biliverdin, which is subsequently converted to bilirubin.	Iron	122-126	heme oxygenase 1	Homo sapiens	31-35
28302014-3	2017	Hepcidin-25 (hepcidin) has emerged as a molecule that regulates iron metabolism.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	13-21
28302014-4	2017	Binding of hepcidin to its receptor, ferroportin, inhibits intestinal iron absorption and iron efflux from hepatocytes and macrophages.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	11-19
24532803-6	2014	We observed that the chelator, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), which forms redox-active iron and copper complexes, effectively induced ER stress as shown by activation of the PERK/eIF2alpha pathway.	Iron	118-122	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	205-209
28302014-4	2017	Binding of hepcidin to its receptor, ferroportin, inhibits intestinal iron absorption and iron efflux from hepatocytes and macrophages.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	11-19
24765096-9	2014	Expression levels of the iron storage protein, ferritin, were higher in the transgenic leaves than in wild-type, suggesting that the excess iron may be stored as ferritin in the leaves and therefore unavailable for phloem loading and delivery to the seeds.	Iron	25-29	ferritin-1, chloroplastic	Glycine max	47-55
27923678-1	2017	MitoNEET, a primary target of type II diabetes drug pioglitazone, has an essential role in regulating energy metabolism, iron homeostasis, and production of reactive oxygen species in mitochondria.	Iron	121-125	CDGSH iron sulfur domain 1	Homo sapiens	0-8
24765096-9	2014	Expression levels of the iron storage protein, ferritin, were higher in the transgenic leaves than in wild-type, suggesting that the excess iron may be stored as ferritin in the leaves and therefore unavailable for phloem loading and delivery to the seeds.	Iron	25-29	ferritin-1, chloroplastic	Glycine max	162-170
24765096-9	2014	Expression levels of the iron storage protein, ferritin, were higher in the transgenic leaves than in wild-type, suggesting that the excess iron may be stored as ferritin in the leaves and therefore unavailable for phloem loading and delivery to the seeds.	Iron	140-144	ferritin-1, chloroplastic	Glycine max	47-55
24765096-9	2014	Expression levels of the iron storage protein, ferritin, were higher in the transgenic leaves than in wild-type, suggesting that the excess iron may be stored as ferritin in the leaves and therefore unavailable for phloem loading and delivery to the seeds.	Iron	140-144	ferritin-1, chloroplastic	Glycine max	162-170
24521359-7	2014	The pro-inflammatory cytokine IL-1beta facilitates divalent metal transporter 1 (DMT1)-induced beta-cell iron uptake and consequently ROS formation and apoptosis, and we propose that this mechanism provides the relay between inflammation and oxidative beta-cell damage.	Iron	105-109	solute carrier family 11 member 2	Homo sapiens	51-79
24521359-7	2014	The pro-inflammatory cytokine IL-1beta facilitates divalent metal transporter 1 (DMT1)-induced beta-cell iron uptake and consequently ROS formation and apoptosis, and we propose that this mechanism provides the relay between inflammation and oxidative beta-cell damage.	Iron	105-109	solute carrier family 11 member 2	Homo sapiens	81-85
29081415-8	2017	The degree of altered iron accumulations was correlated to the amount of amyloid-beta plaques and tau pathology in the same block, as well as to Braak stage (p < 0.001).	Iron	22-26	microtubule associated protein tau	Homo sapiens	98-101
24860871-1	2014	Growth differentiation factor 15 (GDF-15) is a bone marrow-derived cytokine whose ability to suppress iron regulator hepcidin in vitro and increased concentrations found in patients with ineffective erythropoiesis (IE)suggest that hepcidin deficiency mediated by GDF-15 may be the pathophysiological explanation for nontransfusional iron overload.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	117-125
27836659-14	2017	Hepcidin concentrations were greater than previously reported in healthy, pregnant, primarily White women, which suggests decreased iron bioavailability in this high-risk group.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	0-8
24619231-4	2014	With two exemplary cores we demonstrate that the dissolution of particulate Fe and Mn is coupled to the anaerobic oxidation of CH4 (AOM) either via the reduction of sulphate (SO4(2-)) and the subsequent generation of Fe(II) by S(-II) oxidation, or directly coupled to Fe reduction.	Iron	76-78	transcription elongation factor A1	Homo sapiens	227-232
27281679-11	2017	Systemic treatment with EPO or EPO-R76E beginning before or soon after trauma may exacerbate protective effects of EPO within the retina as a result of increased iron levels from erythropoiesis and, thus, increased oxidative stress within the retina.	Iron	162-166	erythropoietin	Mus musculus	24-27
24509156-0	2014	Ceruloplasmin and beta-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron.	Iron	117-121	ceruloplasmin	Mus musculus	0-13
24509156-0	2014	Ceruloplasmin and beta-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron.	Iron	117-121	amyloid beta (A4) precursor protein	Mus musculus	18-48
24509156-2	2014	Ceruloplasmin (CP) and beta-amyloid protein precursor (APP) are known neuroprotective proteins that reduce oxidative damage through iron regulation.	Iron	132-136	ceruloplasmin	Mus musculus	0-13
24509156-2	2014	Ceruloplasmin (CP) and beta-amyloid protein precursor (APP) are known neuroprotective proteins that reduce oxidative damage through iron regulation.	Iron	132-136	ceruloplasmin	Mus musculus	15-17
24509156-2	2014	Ceruloplasmin (CP) and beta-amyloid protein precursor (APP) are known neuroprotective proteins that reduce oxidative damage through iron regulation.	Iron	132-136	amyloid beta (A4) precursor protein	Mus musculus	23-53
27281679-11	2017	Systemic treatment with EPO or EPO-R76E beginning before or soon after trauma may exacerbate protective effects of EPO within the retina as a result of increased iron levels from erythropoiesis and, thus, increased oxidative stress within the retina.	Iron	162-166	erythropoietin	Mus musculus	31-34
27281679-11	2017	Systemic treatment with EPO or EPO-R76E beginning before or soon after trauma may exacerbate protective effects of EPO within the retina as a result of increased iron levels from erythropoiesis and, thus, increased oxidative stress within the retina.	Iron	162-166	erythropoietin	Mus musculus	31-34
24744767-6	2014	These atypical chains perform a range of diverse functions, including the regulation of iron uptake in response to perceived deficiency, repair of double stranded breaks in the DNA, and regulation of the auxin response through the non-proteasomal degradation of auxin efflux carrier protein PIN1.	Iron	88-92	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	291-295
27867027-0	2017	Therapeutic potential of hepcidin - the master regulator of iron metabolism.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	25-33
27867027-3	2017	The peptide hormone hepcidin serves as a master regulator of iron homeostasis on the level of single cells and whole organism - by altering cell surface expression of cellular iron exporter - protein ferroportin.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	20-28
24225901-0	2014	Iron regulation in athletes: exploring the menstrual cycle and effects of different exercise modalities on hepcidin production.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	107-115
24225901-4	2014	Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	123-131
27867027-3	2017	The peptide hormone hepcidin serves as a master regulator of iron homeostasis on the level of single cells and whole organism - by altering cell surface expression of cellular iron exporter - protein ferroportin.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	20-28
24225901-4	2014	Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	123-131
24225901-5	2014	As such, when hepcidin levels are elevated, iron absorption and recycling may be compromised.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	14-22
27867027-4	2017	Altered levels of extracellular hepcidin lead to pathological conditions such as hemochromatosis and iron loading or, on the other side, iron restrictive anemias.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	32-40
27867027-4	2017	Altered levels of extracellular hepcidin lead to pathological conditions such as hemochromatosis and iron loading or, on the other side, iron restrictive anemias.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	32-40
24868988-2	2014	Iron plays major roles in oxygen transport (eg, hemoglobin; -67% of total body iron [TBI]), short-term oxygen storage (eg, myoglobin; -3.5% of TBI), and energy generation (eg, cytochromes; -3% of TBI).	Iron	0-4	myoglobin	Homo sapiens	123-132
24748710-2	2014	All adopt an anti arrangement of the dithiolate bridges, and PPh3 substitution occurs at the apical positions of the outer iron atoms, while the diphosphine complexes exist only in the dibasal form in both the solid state and solution.	Iron	123-127	protein phosphatase 4 catalytic subunit	Homo sapiens	61-65
28442790-5	2016	In CSF, 5-HT level is significantly decreased and the levels of iron and transferrin are dramatically increased in fatigue group.	Iron	64-68	colony stimulating factor 2	Homo sapiens	3-6
25097830-3	2014	Hepcidin-25 (hepcidin), the key iron regulating hormone, prevents iron egress from macrophages and thus prevents normal recycling of the iron needed to support erythropoiesis.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-11
25097830-3	2014	Hepcidin-25 (hepcidin), the key iron regulating hormone, prevents iron egress from macrophages and thus prevents normal recycling of the iron needed to support erythropoiesis.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	13-21
25097830-3	2014	Hepcidin-25 (hepcidin), the key iron regulating hormone, prevents iron egress from macrophages and thus prevents normal recycling of the iron needed to support erythropoiesis.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-11
25097830-3	2014	Hepcidin-25 (hepcidin), the key iron regulating hormone, prevents iron egress from macrophages and thus prevents normal recycling of the iron needed to support erythropoiesis.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	13-21
25097830-3	2014	Hepcidin-25 (hepcidin), the key iron regulating hormone, prevents iron egress from macrophages and thus prevents normal recycling of the iron needed to support erythropoiesis.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-11
25097830-3	2014	Hepcidin-25 (hepcidin), the key iron regulating hormone, prevents iron egress from macrophages and thus prevents normal recycling of the iron needed to support erythropoiesis.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	13-21
28442790-6	2016	In fatigue group, mental fatigue score is negatively correlated with 5-HT level in CSF, and positively correlated with the scores of depression and excessive daytime sleepiness, and disease duration, also, mental fatigue is positively correlated with the levels of iron and transferrin in CSF.	Iron	265-269	colony stimulating factor 2	Homo sapiens	289-292
27451180-2	2016	On the other hand, plant ferritin represents not only a novel class of iron supplement, but also a new nanocarrier for encapsulation of bioactive nutrients.	Iron	71-75	ferritin-1, chloroplastic	Glycine max	25-33
24625978-0	2014	Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress.	Iron	114-118	aggrecan	Mus musculus	0-8
23901875-0	2014	Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor.	Iron	22-26	hemojuvelin BMP co-receptor	Homo sapiens	0-11
23901875-2	2014	Systemic iron homeostasis is controlled by the hemojuvelin-hepcidin-ferroportin axis in the liver, but less is known about this role in AKI.	Iron	9-13	hemojuvelin BMP co-receptor	Homo sapiens	47-58
27696386-2	2016	Novel hepcidin antagonists have recently been introduced as potential treatment for iron-restricted anaemia.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	6-14
23901875-2	2014	Systemic iron homeostasis is controlled by the hemojuvelin-hepcidin-ferroportin axis in the liver, but less is known about this role in AKI.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	59-67
23901875-5	2014	Iron overload enhanced the expression of hemojuvelin-hepcidin signaling pathway.	Iron	0-4	hemojuvelin BMP co-receptor	Homo sapiens	41-52
23901875-5	2014	Iron overload enhanced the expression of hemojuvelin-hepcidin signaling pathway.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	53-61
23901875-10	2014	CONCLUSION: Our findings link endogenous HJV inextricably with renal iron homeostasis for the first time, add new significance to early predict AKI, and identify novel therapeutic targets to reduce the severity of AKI using the FI.	Iron	69-73	hemojuvelin BMP co-receptor	Homo sapiens	41-44
29195869-0	2016	Lactoferrin-based nanoparticles as a vehicle for iron in food applications - Development and release profile.	Iron	49-53	lactotransferrin	Bos taurus	0-11
24385536-1	2014	The hepatic hormone hepcidin is a key regulator of systemic iron metabolism.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	20-28
24385536-2	2014	Its expression is largely regulated by 2 signaling pathways: the "iron-regulated" bone morphogenetic protein (BMP) and the inflammatory JAK-STAT pathways.	Iron	66-70	bone morphogenetic protein 1	Homo sapiens	82-108
24385536-2	2014	Its expression is largely regulated by 2 signaling pathways: the "iron-regulated" bone morphogenetic protein (BMP) and the inflammatory JAK-STAT pathways.	Iron	66-70	bone morphogenetic protein 1	Homo sapiens	110-113
29195869-1	2016	This study aims at developing and characterizing bovine lactoferrin (bLf) nanoparticles as an iron carrier.	Iron	94-98	lactotransferrin	Bos taurus	56-67
28046154-1	2016	Two experiments were conducted with 28-d-old commercial male broilers to study the kinetics of iron (Fe) absorption and the effect of Fe treatment on divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) mRNA levels in in situ ligated segments from different small intestinal regions of broilers.	Iron	134-136	solute carrier family 11 member 2	Homo sapiens	150-178
24398330-1	2014	Hepcidin controls systemic iron availability, and its excess contributes to the anemia of chronic diseases, the most prevalent anemia in hospitalized patients.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
24639653-0	2014	The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body.	Iron	64-68	transferrin receptor 2	Homo sapiens	20-42
24639653-2	2014	The putative iron sensor, transferrin receptor 2 (TfR2), is expressed in the liver and mutations in this protein result in the iron-overload disease Type III hereditary hemochromatosis (HH).	Iron	13-17	transferrin receptor 2	Homo sapiens	26-48
28046154-1	2016	Two experiments were conducted with 28-d-old commercial male broilers to study the kinetics of iron (Fe) absorption and the effect of Fe treatment on divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) mRNA levels in in situ ligated segments from different small intestinal regions of broilers.	Iron	134-136	solute carrier family 11 member 2	Homo sapiens	180-184
24639653-2	2014	The putative iron sensor, transferrin receptor 2 (TfR2), is expressed in the liver and mutations in this protein result in the iron-overload disease Type III hereditary hemochromatosis (HH).	Iron	13-17	transferrin receptor 2	Homo sapiens	50-54
24639653-3	2014	With the loss of functional TfR2, the liver produces about 2-fold less of the peptide hormone hepcidin, which is responsible for negatively regulating iron uptake from the diet.	Iron	151-155	transferrin receptor 2	Homo sapiens	28-32
28046154-1	2016	Two experiments were conducted with 28-d-old commercial male broilers to study the kinetics of iron (Fe) absorption and the effect of Fe treatment on divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) mRNA levels in in situ ligated segments from different small intestinal regions of broilers.	Iron	134-136	solute carrier family 40 member 1	Homo sapiens	190-203
24639653-3	2014	With the loss of functional TfR2, the liver produces about 2-fold less of the peptide hormone hepcidin, which is responsible for negatively regulating iron uptake from the diet.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	94-102
24639653-4	2014	This reduction in hepcidin expression leads to the slow accumulation of iron in the liver, heart, joints, and pancreas and subsequent cirrhosis, heart disease, arthritis, and diabetes.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	18-26
24639653-5	2014	TfR2 can bind iron-loaded transferrin (Tf) in the bloodstream, and hepatocytes treated with Tf respond with a 2-fold increase in hepcidin expression through stimulation of the bone morphogenetic protein (BMP)-signaling pathway.	Iron	14-18	transferrin receptor 2	Homo sapiens	0-4
24639653-5	2014	TfR2 can bind iron-loaded transferrin (Tf) in the bloodstream, and hepatocytes treated with Tf respond with a 2-fold increase in hepcidin expression through stimulation of the bone morphogenetic protein (BMP)-signaling pathway.	Iron	14-18	bone morphogenetic protein 1	Homo sapiens	176-202
27211273-7	2016	We describe cryptic splicing events in the HSCs of SF3B1-mutant MDS, and our data support a model in which NMD-induced downregulation of the iron exporter ABCB7 mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 underlies the increased mitochondrial iron accumulation found in MDS patients with RS.	Iron	141-145	ATP binding cassette subfamily B member 7	Homo sapiens	155-160
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	55-67
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	0-4	ceruloplasmin	Homo sapiens	112-125
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	35-39	solute carrier family 40 member 1	Homo sapiens	55-67
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	35-39	ceruloplasmin	Homo sapiens	112-125
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	147-151	solute carrier family 40 member 1	Homo sapiens	55-67
27211273-7	2016	We describe cryptic splicing events in the HSCs of SF3B1-mutant MDS, and our data support a model in which NMD-induced downregulation of the iron exporter ABCB7 mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 underlies the increased mitochondrial iron accumulation found in MDS patients with RS.	Iron	271-275	ATP binding cassette subfamily B member 7	Homo sapiens	155-160
24132807-6	2014	Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin.	Iron	147-151	ceruloplasmin	Homo sapiens	112-125
27923109-2	2016	GLRX3 is expressed in many tissues and plays important roles in iron metabolism, antioxidant effect, cell proliferation and development, regulation of immune reaction, and tumorigenesis.	Iron	64-68	glutaredoxin 3	Homo sapiens	0-5
24132807-7	2014	The regulation of iron export is controlled predominantly at the systemic level by the master regulator of iron homeostasis hepcidin.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	124-132
24132807-7	2014	The regulation of iron export is controlled predominantly at the systemic level by the master regulator of iron homeostasis hepcidin.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	124-132
24132807-8	2014	Hepcidin, in turn, responds to changes in body iron demand, making use of a range of regulatory mechanisms that center on the bone morphogenetic protein signaling pathway.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
27901468-5	2016	In fh mutants, iron accumulation in the nervous system enhances the synthesis of sphingolipids, which in turn activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2) to trigger neurodegeneration of adult photoreceptors.	Iron	15-19	Myocyte enhancer factor 2	Drosophila melanogaster	204-208
24325979-0	2014	Iron and fibroblast growth factor 23 in X-linked hypophosphatemia.	Iron	0-4	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	40-65
27653419-7	2016	The focus of this study was to test whether the monothiol glutaredoxin, Grx4, functions as an obligate [2Fe-2S] carrier protein in the Fe-S cluster distribution network.	Iron	105-107	glutaredoxin 3	Homo sapiens	72-76
24325979-3	2014	We hypothesized that in XLH serum iron would inversely correlate to C-terminal FGF23, but not to intact FGF23, mirroring the relationships in normal controls.	Iron	34-38	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	24-27
24325979-7	2014	In XLH, iron correlated negatively to log-C-terminal FGF23 (r=-0.523, p&lt;0.01), with a steeper slope than in controls (p&lt;0.001).	Iron	8-12	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	3-6
27653419-9	2016	Further, we provide evidence that [2Fe-2S]-Grx4 delivers clusters to multiple classes of Fe-S targets via direct ligand exchange in a process that is both dynamic and reversible.	Iron	89-93	glutaredoxin 3	Homo sapiens	43-47
23557349-0	2014	Novel ceruloplasmin mutation causing aceruloplasminemia with hepatic iron overload and diabetes without neurological symptoms.	Iron	69-73	ceruloplasmin	Homo sapiens	6-19
27681840-10	2016	Since anti-inflammatory actions mediated through CB2 would be associated with reduced DMT1 phosphorylation, we postulate that this pathway provides a means to reduce oxidative stress by limiting iron uptake.	Iron	195-199	cannabinoid receptor 2	Homo sapiens	49-52
24373749-11	2014	Our results suggest that IL6 released by portal macrophages may regulate hepatocyte hepcidin expression via STAT3 activation during transient iron overload in TAA-induced acute liver injury.	Iron	142-146	signal transducer and activator of transcription 3	Rattus norvegicus	108-113
27681840-10	2016	Since anti-inflammatory actions mediated through CB2 would be associated with reduced DMT1 phosphorylation, we postulate that this pathway provides a means to reduce oxidative stress by limiting iron uptake.	Iron	195-199	solute carrier family 11 member 2	Homo sapiens	86-90
27891139-10	2016	Furthermore, excess Fe showed increased catalase, peroxidase, and glutathione reductase activities along with glutathione, cysteine, and proline accumulation in roots in BR 27.	Iron	20-22	peroxidase-like	Triticum aestivum	50-60
24275120-3	2014	Chronic inflammation is a common condition in older people, making the measurement of iron status difficult, and it is likely that elevated levels of circulating hepcidin are responsible for changes in iron metabolism that result in systemic iron depletion.	Iron	202-206	hepcidin antimicrobial peptide	Homo sapiens	162-170
24275120-3	2014	Chronic inflammation is a common condition in older people, making the measurement of iron status difficult, and it is likely that elevated levels of circulating hepcidin are responsible for changes in iron metabolism that result in systemic iron depletion.	Iron	202-206	hepcidin antimicrobial peptide	Homo sapiens	162-170
27687671-1	2016	MitoNEET (CISD1) is a 2Fe-2S iron-sulfur cluster protein belonging to the zinc-finger protein family.	Iron	29-33	CDGSH iron sulfur domain 1	Homo sapiens	0-8
24393578-4	2014	However, the emerging details of the physiology of hepcidin, the key hormone in iron recycling, suggest a resolution of the apparent paradox of an important role for iron in atherogenesis in the possible absence of increased plaque burden in most types of hereditary hemochromatosis.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	51-59
24393578-4	2014	However, the emerging details of the physiology of hepcidin, the key hormone in iron recycling, suggest a resolution of the apparent paradox of an important role for iron in atherogenesis in the possible absence of increased plaque burden in most types of hereditary hemochromatosis.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	51-59
24552640-2	2014	Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	35-43
27687671-1	2016	MitoNEET (CISD1) is a 2Fe-2S iron-sulfur cluster protein belonging to the zinc-finger protein family.	Iron	29-33	CDGSH iron sulfur domain 1	Homo sapiens	10-15
24552640-2	2014	Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	35-43
24552640-3	2014	Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical illness, some cancers, and chronic kidney disease.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	9-17
27519153-3	2016	Hepcidin levels are increased in response to inflammation causing subsequent decreases in ferroportin and available iron needed for myelination.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	0-8
27805332-1	2016	AIM: To evaluate reticulocyte hemoglobin (RET-He) vis-a-vis serum ferritin as a marker of bone marrow iron store in iron deficiency anemia (IDA).	Iron	102-106	ret proto-oncogene	Homo sapiens	42-45
24577088-2	2014	MicroRNA-210 (miR-210) is regulated by hypoxia-inducible transcription factor-1alpha (HIF-1alpha) under hypoxic conditions and controls mitochondrial energy metabolism by repressing the iron-sulfur cluster assembly protein (ISCU1/2).	Iron	186-190	hypoxia inducible factor 1, alpha subunit	Mus musculus	86-96
27617496-9	2016	In conclusion, 30% of subjects treated with interferon exhibited significant transient increase in serum hepcidin levels, which was associated with more extreme anemia and decreased iron availability as evidenced by decreased reticulocyte Hb.	Iron	182-186	hepcidin antimicrobial peptide	Homo sapiens	105-113
24533165-0	2014	Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells.	Iron	62-66	ceruloplasmin	Homo sapiens	11-24
24533165-0	2014	Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	29-37
24533165-3	2014	We found that iron efflux from hBMVEC through the ferrous iron permease ferroportin (Fpn) was stimulated by secretion of the soluble form of the multi-copper ferroxidase, ceruloplasmin (sCp) from the co-cultured C6 cells.	Iron	14-18	ceruloplasmin	Homo sapiens	171-184
24533165-6	2014	This hepcidin-dependent loss of Fpn correlated with knock-down of iron efflux from the hBMVEC; this result was consistent with the mechanism by which hepcidin regulates iron efflux in mammalian cells.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	5-13
24533165-6	2014	This hepcidin-dependent loss of Fpn correlated with knock-down of iron efflux from the hBMVEC; this result was consistent with the mechanism by which hepcidin regulates iron efflux in mammalian cells.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	150-158
27655758-1	2016	BACKGROUND: Hepcidin mediates the hypoferremia of inflammation by inhibiting iron transfer into circulation; however, a regulator for the hypozincemia observed in individuals with acute and chronic inflammatory and infectious diseases is not known.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	12-20
24533165-6	2014	This hepcidin-dependent loss of Fpn correlated with knock-down of iron efflux from the hBMVEC; this result was consistent with the mechanism by which hepcidin regulates iron efflux in mammalian cells.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	5-13
24533165-6	2014	This hepcidin-dependent loss of Fpn correlated with knock-down of iron efflux from the hBMVEC; this result was consistent with the mechanism by which hepcidin regulates iron efflux in mammalian cells.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	150-158
24422557-8	2014	We further demonstrate that yeast Dph3 (also known as KTI11), a CSL-type zinc finger protein, can bind iron and in the reduced state can serve as an electron donor to reduce the Fe-S cluster in Dph1-Dph2.	Iron	103-107	Kti11p	Saccharomyces cerevisiae S288C	54-59
24422557-8	2014	We further demonstrate that yeast Dph3 (also known as KTI11), a CSL-type zinc finger protein, can bind iron and in the reduced state can serve as an electron donor to reduce the Fe-S cluster in Dph1-Dph2.	Iron	178-182	Kti11p	Saccharomyces cerevisiae S288C	54-59
26728570-6	2016	Overlap (P&lt;0.0001) of differentially expressed genes in Hfe-/- x Tfr2mut brain with human gene co-expression networks suggests iron loading influences expression of NBIA-related and myelin-related genes co-expressed in normal human basal ganglia.	Iron	130-134	transferrin receptor 2	Homo sapiens	68-72
27519415-4	2016	To explore these questions, we use quantitative immunoprecipitation and live cell proximity-dependent biotinylation to monitor interactions between Glrx3, BolA2, and components of the cytosolic iron-sulfur cluster assembly system.	Iron	194-198	glutaredoxin 3	Homo sapiens	148-153
24161741-3	2014	One of the identified natural substrates is hemojuvelin, a protein involved in the control of iron homeostasis.	Iron	94-98	hemojuvelin BMP co-receptor	Homo sapiens	44-55
27519415-6	2016	Unlike complexes formed by fungal orthologs, human Glrx3-BolA2 interaction required the coordination of Fe-S clusters, whereas Glrx3 homodimer formation did not.	Iron	104-108	glutaredoxin 3	Homo sapiens	51-56
24318355-2	2014	Four isoforms of DMT1 have been identified in mammalian cells encoded by a single gene that differ both in their N- and C-terminal sequences with two mRNA isoforms possessing an iron response element (IRE) motif downstream from the stop codon on the message.	Iron	178-182	solute carrier family 11 member 2	Homo sapiens	17-21
27519415-7	2016	Cellular Glrx3 BolA2 complexes increased 6-8-fold in response to increasing iron, forming a rapidly expandable pool of Fe-S clusters.	Iron	76-80	glutaredoxin 3	Homo sapiens	9-14
27519415-7	2016	Cellular Glrx3 BolA2 complexes increased 6-8-fold in response to increasing iron, forming a rapidly expandable pool of Fe-S clusters.	Iron	119-123	glutaredoxin 3	Homo sapiens	9-14
27519415-8	2016	Fe-S coordination by Glrx3 BolA2 did not depend on Ciapin1 or Ciao1, proteins that bind Glrx3 and are involved in cytosolic Fe-S cluster assembly and distribution.	Iron	0-4	glutaredoxin 3	Homo sapiens	21-26
23907767-0	2014	Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	140-148
27519415-8	2016	Fe-S coordination by Glrx3 BolA2 did not depend on Ciapin1 or Ciao1, proteins that bind Glrx3 and are involved in cytosolic Fe-S cluster assembly and distribution.	Iron	0-4	glutaredoxin 3	Homo sapiens	88-93
23907767-1	2014	UNLABELLED: Gender-related disparities in the regulation of iron metabolism may contribute to the differences exhibited by men and women in the progression of chronic liver diseases associated with reduced hepcidin expression, e.g., chronic hepatitis C, alcoholic liver disease, or hereditary hemochromatosis.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	206-214
23907767-5	2014	In males, where the suppressive effects of testosterone and Bmp6-deficiency on hepcidin expression are combined, hepcidin is more strongly repressed than in females and iron accumulates massively not only in the liver but also in the pancreas, heart, and kidneys.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	79-87
23907767-6	2014	CONCLUSION: Testosterone-induced repression of hepcidin expression becomes functionally important during homeostatic stress from disorders that result in iron loading and/or reduced capacity for hepcidin synthesis.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	47-55
23907767-7	2014	These findings suggest that novel therapeutic strategies targeting the testosterone/EGF/EGFR axis may be useful for inducing hepcidin expression in patients with iron overload and/or chronic liver diseases.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	125-133
27519415-9	2016	Instead, Glrx3 and BolA2 bound and facilitated Fe-S incorporation into Ciapin1, a [2Fe-2S] protein functioning early in the cytosolic Fe-S assembly pathway.	Iron	47-51	glutaredoxin 3	Homo sapiens	9-14
27519415-9	2016	Instead, Glrx3 and BolA2 bound and facilitated Fe-S incorporation into Ciapin1, a [2Fe-2S] protein functioning early in the cytosolic Fe-S assembly pathway.	Iron	134-138	glutaredoxin 3	Homo sapiens	9-14
27740603-1	2016	The effects of polyphenol-rich foods on the iron status of athletes, as well as the effect of physical training on the hormone hepcidin, implicated in iron metabolism, are not clear.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	127-135
24401274-6	2014	Transfection of a CXCR4-expressing human cell line with an iron-deficient FHC mutant confirmed that increased FHC expression deregulated CXCR4 signaling and that this function of FHC was independent of iron binding.	Iron	59-63	ferritin heavy chain 1	Homo sapiens	74-77
24401274-6	2014	Transfection of a CXCR4-expressing human cell line with an iron-deficient FHC mutant confirmed that increased FHC expression deregulated CXCR4 signaling and that this function of FHC was independent of iron binding.	Iron	59-63	ferritin heavy chain 1	Homo sapiens	110-113
24121126-8	2014	Taken together with previous findings in model systems, our results suggest that TF or a TF-TFR2 complex may have a role in the etiology of PD, possibly through iron misregulation or mitochondrial dysfunction within dopaminergic neurons.	Iron	161-165	transferrin receptor 2	Homo sapiens	92-96
27740603-6	2016	Further studies are required to ascertain the time and conditions necessary to restore hepcidin levels, which reflect the iron status of triathletes.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	87-95
27352871-1	2016	Hepcidin, the master regulator of bioavailable iron, is a key mediator of anemia and also plays a central role in host defense against infection.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
24512616-5	2014	We have previously shown that exposure to relatively high doses of high-energy (56)Fe ions induced higher intestinal tumor frequency and grade in the small intestine of Apc(Min/+) mice than gamma rays.	Iron	83-85	APC, WNT signaling pathway regulator	Mus musculus	169-172
27352871-2	2016	We hypothesized that measuring hepcidin levels in cord blood could provide an early indication of interindividual differences in iron regulation with quantifiable implications for anemia, malaria, and mortality-related risk.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	31-39
27352871-4	2016	At the time of delivery, cord hepcidin levels were correlated with inflammatory mediators, iron markers, and maternal health conditions.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	30-38
27576776-2	2016	Hepcidin plays an important role in regulating iron metabolism, and we have reported that serum hepcidin is positively correlated with poor outcomes in patients with ICH.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
24183966-8	2014	HO-1 may also contribute to the iron accumulation in neurons, but its mechanism needs to be further investigated.	Iron	32-36	heme oxygenase 1	Homo sapiens	0-4
27576776-2	2016	Hepcidin plays an important role in regulating iron metabolism, and we have reported that serum hepcidin is positively correlated with poor outcomes in patients with ICH.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	96-104
24424315-3	2014	Native LF, iron-saturated LF (holo-LF), and apolactoferrin (apo-LF) effectively suppressed strand breaks in plasmid DNA due to hydroxyl radicals produced by the Fenton reaction.	Iron	11-15	lactotransferrin	Bos taurus	26-28
27694815-4	2016	Hepcidin is a key regulator of iron homeostasis whose expression changes are often indicative of abnormal iron metabolism.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
24424315-3	2014	Native LF, iron-saturated LF (holo-LF), and apolactoferrin (apo-LF) effectively suppressed strand breaks in plasmid DNA due to hydroxyl radicals produced by the Fenton reaction.	Iron	11-15	lactotransferrin	Bos taurus	30-37
24424315-3	2014	Native LF, iron-saturated LF (holo-LF), and apolactoferrin (apo-LF) effectively suppressed strand breaks in plasmid DNA due to hydroxyl radicals produced by the Fenton reaction.	Iron	11-15	lactotransferrin	Bos taurus	26-28
24454764-4	2014	Despite liver iron overload, expression of bone morphogenetic protein 6 (Bmp6), a potent-stimulator of Hamp1 expression that is expressed under iron-loaded conditions, was decreased.	Iron	144-148	bone morphogenetic protein 6	Mus musculus	43-71
27694815-9	2016	Iron-loading, viral infection and liver dysfunction are determined to be the major regulators of hepcidin in these patients.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	97-105
24454764-4	2014	Despite liver iron overload, expression of bone morphogenetic protein 6 (Bmp6), a potent-stimulator of Hamp1 expression that is expressed under iron-loaded conditions, was decreased.	Iron	144-148	bone morphogenetic protein 6	Mus musculus	73-77
27733315-1	2016	BACKGROUND: The liver, as the main iron storage compartment and the place of hepcidin synthesis, is the central organ involved in maintaining iron homeostasis in the body.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	77-85
24454764-7	2014	Moreover, Bmp6 was down-regulated under conditions of high iron demand, irrespective of the presence of anemia.	Iron	59-63	bone morphogenetic protein 6	Mus musculus	10-14
24454764-9	2014	Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression, and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression.	Iron	66-70	SMAD family member 1	Mus musculus	102-109
24454764-9	2014	Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression, and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression.	Iron	66-70	bone morphogenetic protein 6	Mus musculus	255-259
24454764-9	2014	Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression, and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression.	Iron	190-194	bone morphogenetic protein 6	Mus musculus	255-259
27040361-0	2016	Iron Together with Lipid Downregulates Protein Levels of Ceruloplasmin in Macrophages Associated with Rapid Foam Cell Formation.	Iron	0-4	ceruloplasmin	Mus musculus	57-70
24200681-6	2014	Here we review how the liver is the central conductor of systemic iron balance and show that this central role is related to the secretion of a peptide hormone hepcidin by hepatocytes.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	160-168
24200681-7	2014	We then review how the liver receives and integrates the many signals that report the body"s iron needs to orchestrate hepcidin production and maintain systemic iron homeostasis.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	119-127
27040361-3	2016	Ceruloplasmin (Cp) is an important factor in cellular iron efflux and was found to be downregulated in atherosclerotic plaques in our previous study.	Iron	54-58	ceruloplasmin	Mus musculus	0-13
27763254-4	2016	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	73-81
24284962-4	2014	Specifically, Bmp6 expression is upregulated in response to iron and induces hepcidin through phosphorylation of Smad1/5/8.	Iron	60-64	bone morphogenetic protein 6	Mus musculus	14-18
24284962-7	2014	Systematic analysis demonstrated that Tfr2 is required for effective upregulation of Bmp6 in response to hepatocyte iron, but not nonparenchymal iron.	Iron	116-120	bone morphogenetic protein 6	Mus musculus	85-89
24995692-3	2014	Specifically, BMP6 serves to relate hepatic iron stores to the hepatocellular expression of the iron-regulatory hormone hepcidin.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	120-128
27763254-4	2016	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	73-81
24995692-5	2014	Mutations in certain genes influencing signaling to hepcidin via the BMP/SMAD pathway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and iron-refractory iron-deficiency anemia.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	52-60
24995692-5	2014	Mutations in certain genes influencing signaling to hepcidin via the BMP/SMAD pathway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and iron-refractory iron-deficiency anemia.	Iron	125-129	bone morphogenetic protein 1	Homo sapiens	69-72
26922566-1	2016	BACKGROUND: The present study was conducted to assess the maternal and cord blood hepcidin concentrations in severe iron deficiency anemia (IDA) and to find out its correlation with other iron status parameters.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	82-90
24995692-5	2014	Mutations in certain genes influencing signaling to hepcidin via the BMP/SMAD pathway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and iron-refractory iron-deficiency anemia.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	52-60
24995692-5	2014	Mutations in certain genes influencing signaling to hepcidin via the BMP/SMAD pathway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and iron-refractory iron-deficiency anemia.	Iron	181-185	bone morphogenetic protein 1	Homo sapiens	69-72
24995692-6	2014	Evidence suggests that signals in addition to iron stores influence hepcidin expression via the BMP/SMAD pathway.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	68-76
26922566-10	2016	Significant correlation was observed among maternal and cord blood hepcidin concentrations and other iron status parameters.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	67-75
24995692-7	2014	This review summarizes the details of BMP/SMAD signaling, with a particular focus on its role in iron homeostasis and iron-related diseases.	Iron	97-101	bone morphogenetic protein 1	Homo sapiens	38-41
24995692-7	2014	This review summarizes the details of BMP/SMAD signaling, with a particular focus on its role in iron homeostasis and iron-related diseases.	Iron	118-122	bone morphogenetic protein 1	Homo sapiens	38-41
27604527-1	2016	Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of which is subsequently converted to bilirubin.	Iron	126-138	heme oxygenase 1	Homo sapiens	46-51
27284811-1	2016	BACKGROUND: Urine hepcidin measurement is a potential non-invasive tool for assessing iron stores.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	18-26
25580431-0	2014	Iron as the key modulator of hepcidin expression in erythroid antibody-mediated hypoplasia.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	29-37
25580431-4	2014	Serum iron was increased and associated with mRNA overexpression of hepatic hepcidin and other iron regulatory mediators and downregulation of matriptase-2; overexpression of divalent metal transporter 1 and ferroportin was observed in duodenum and liver.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	76-84
25580431-4	2014	Serum iron was increased and associated with mRNA overexpression of hepatic hepcidin and other iron regulatory mediators and downregulation of matriptase-2; overexpression of divalent metal transporter 1 and ferroportin was observed in duodenum and liver.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	76-84
25580431-8	2014	This leads to a serum iron increase, which seems to stimulate hepcidin expression despite no evidence of inflammation, thus suggesting iron as the key modulator of hepcidin synthesis.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	62-70
25580431-8	2014	This leads to a serum iron increase, which seems to stimulate hepcidin expression despite no evidence of inflammation, thus suggesting iron as the key modulator of hepcidin synthesis.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	164-172
25580431-8	2014	This leads to a serum iron increase, which seems to stimulate hepcidin expression despite no evidence of inflammation, thus suggesting iron as the key modulator of hepcidin synthesis.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	62-70
25580431-8	2014	This leads to a serum iron increase, which seems to stimulate hepcidin expression despite no evidence of inflammation, thus suggesting iron as the key modulator of hepcidin synthesis.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	164-172
27688041-0	2016	Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.	Iron	38-42	bone morphogenetic protein 6	Mus musculus	76-80
24316510-1	2014	Pantothenate kinase-associated neurodegeneration, caused by mutations in the PANK2 gene, is an autosomal recessive disorder characterized by dystonia, dysarthria, rigidity, pigmentary retinal degeneration and brain iron accumulation.	Iron	215-219	pantothenate kinase 2	Mus musculus	77-82
27688041-7	2016	Finally, overexpression of SHP and metformin treatment of BMP6 stimulated mice substantially restored hepcidin expression and serum iron to baseline levels.	Iron	132-136	bone morphogenetic protein 6	Mus musculus	58-62
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	78-82	solute carrier family 11 member 2	Homo sapiens	32-36
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	solute carrier family 11 member 2	Homo sapiens	32-36
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	solute carrier family 11 member 2	Homo sapiens	32-36
25483589-1	2014	The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-transferrin bound iron in many cells.	Iron	136-140	solute carrier family 11 member 2	Homo sapiens	32-36
25483589-4	2014	Here we provide additional support for a role of DMT1 in mitochondrial iron acquisition by immunofluorescence colocalization with mitochondrial markers in cells and isolated mitochondria, as well as flow cytometric quantification of DMT1-positive mitochondria from an inducible expression system.	Iron	71-75	solute carrier family 11 member 2	Homo sapiens	49-53
27683879-0	2016	Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue: Application in the APP/PS1 Mouse Model of Alzheimer"s Disease.	Iron	36-40	presenilin 1	Mus musculus	125-128
25651734-2	2014	Hepcidin quantification in human serum provides new insights for the pathogenesis of disorders of iron homeostasis.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
27690059-1	2016	Lactoferrin is an iron-binding protein present in large quantities in colostrum and in breast milk, in external secretions and in polymorphonuclear leukocytes.	Iron	18-22	lactotransferrin	Bos taurus	0-11
24739829-3	2014	AIM: To assess the opposing effects of enhanced erythropoiesis due to anemia and iron overloading on hepcidin in beta-TM patients.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	101-109
24739829-12	2014	The mean serum hepcidin/ferritin index in the study group (0.00552) was significantly lower (P value &lt; 0.001) than the controls (0.378) thus indicating inappropriate levels of hepcidin to iron overload.	Iron	191-195	hepcidin antimicrobial peptide	Homo sapiens	15-23
27690059-3	2016	Among several protective activities shown by lactoferrin, those displayed by orally administered lactoferrin are: (i) antimicrobial activity, which has been presumed due to iron deprivation, but more recently attributed also to a specific interaction with the bacterial cell wall and extended to viruses and parasites; (ii) immunomodulatory activity, with a direct effect on the development of the immune system in the newborn, together with a specific antinflammatory effects; (iii) a more recently discovered anticancer activity.	Iron	173-177	lactotransferrin	Bos taurus	97-108
24739829-13	2014	CONCLUSION: In polytransfused beta-TM children increased iron demand dominates over iron overload in regulating hepcidin.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	112-120
24739829-13	2014	CONCLUSION: In polytransfused beta-TM children increased iron demand dominates over iron overload in regulating hepcidin.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	112-120
27510639-3	2016	Here, we show that CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death.	Iron	25-29	CDGSH iron sulfur domain 1	Homo sapiens	47-52
24739829-14	2014	In spite of excessive iron load, the inappropriate hepcidin levels may further contribute to iron overload enhancing iron toxicity.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	51-59
24739829-14	2014	In spite of excessive iron load, the inappropriate hepcidin levels may further contribute to iron overload enhancing iron toxicity.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	51-59
25762501-2	2014	Hepcidin is the master iron regulating hormone that limits dietary iron absorption from the gut and limits iron egress from macrophages.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
27510639-3	2016	Here, we show that CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death.	Iron	25-29	CDGSH iron sulfur domain 1	Homo sapiens	66-74
25762501-2	2014	Hepcidin is the master iron regulating hormone that limits dietary iron absorption from the gut and limits iron egress from macrophages.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
25762501-2	2014	Hepcidin is the master iron regulating hormone that limits dietary iron absorption from the gut and limits iron egress from macrophages.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	96-100	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	55-59
27510639-4	2016	The classical ferroptosis inducer erastin promotes CISD1 expression in an iron-dependent manner in human hepatocellular carcinoma cells (e.g., HepG2 and Hep3B).	Iron	74-78	CDGSH iron sulfur domain 1	Homo sapiens	51-56
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	96-100	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	253-257
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	144-148	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	55-59
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	144-148	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	253-257
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	144-148	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	55-59
27510639-5	2016	Genetic inhibition of CISD1 increased iron-mediated intramitochondrial lipid peroxidation, which contributes to erastin-induced ferroptosis.	Iron	38-42	CDGSH iron sulfur domain 1	Homo sapiens	22-27
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	144-148	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	253-257
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	144-148	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	55-59
25762501-4	2014	Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis.	Iron	144-148	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	253-257
24174620-0	2014	Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1).	Iron	114-118	ATPase copper transporting alpha	Rattus norvegicus	49-54
24174620-11	2014	This investigation has thus documented alterations in iron homeostasis associated with Atp7a knockdown in enterocyte-like cells.	Iron	54-58	ATPase copper transporting alpha	Rattus norvegicus	87-92
27510639-6	2016	In contrast, stabilization of the iron sulfur cluster of CISD1 by pioglitazone inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.	Iron	34-38	CDGSH iron sulfur domain 1	Homo sapiens	57-62
24174620-12	2014	Alterations in copper transport, trafficking, or distribution may underlie the increase in transepithelial iron flux noted when ATP7A activity is diminished.	Iron	107-111	ATPase copper transporting alpha	Rattus norvegicus	128-133
27510639-6	2016	In contrast, stabilization of the iron sulfur cluster of CISD1 by pioglitazone inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.	Iron	102-106	CDGSH iron sulfur domain 1	Homo sapiens	57-62
27546461-2	2016	Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2alpha-dependent transcription.	Iron	70-74	endothelial PAS domain protein 1	Mus musculus	157-188
24117441-0	2014	AtSIA1 AND AtOSA1: two Abc1 proteins involved in oxidative stress responses and iron distribution within chloroplasts.	Iron	80-84	ABC2 homolog 13	Arabidopsis thaliana	11-17
27598194-8	2016	Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R2 of model including hepcidin = 0.65; R2 of model excluding hepcidin = 0.17, p for difference &lt;0.001), and increased hepcidin diminished the positive association between iron intake and iron stores.	Iron	279-283	hepcidin antimicrobial peptide	Homo sapiens	0-8
24117441-5	2014	Iron uptake from soil is not hampered in mutant lines, suggesting that AtSIA1 and AtOSA1 affect iron distribution within the chloroplast.	Iron	0-4	ABC2 homolog 13	Arabidopsis thaliana	82-88
24117441-5	2014	Iron uptake from soil is not hampered in mutant lines, suggesting that AtSIA1 and AtOSA1 affect iron distribution within the chloroplast.	Iron	96-100	ABC2 homolog 13	Arabidopsis thaliana	82-88
27598194-8	2016	Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R2 of model including hepcidin = 0.65; R2 of model excluding hepcidin = 0.17, p for difference &lt;0.001), and increased hepcidin diminished the positive association between iron intake and iron stores.	Iron	279-283	hepcidin antimicrobial peptide	Homo sapiens	0-8
27598194-11	2016	Interventions that reduce hepcidin production combined with dietary strategies to increase iron intake may be important means of improving iron status in women with depleted iron stores.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	26-34
24672633-4	2014	Copper influences iron content in the brain through ferroxidase ceruloplasmin activity; therefore decreased protein-bound copper in brain may enhance iron accumulation and the associated oxidative stress.	Iron	18-22	ceruloplasmin	Homo sapiens	64-77
27598194-11	2016	Interventions that reduce hepcidin production combined with dietary strategies to increase iron intake may be important means of improving iron status in women with depleted iron stores.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	26-34
28139536-13	2016	Iron nutrition and stress exhibited a positive association through hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	67-75
24391488-0	2014	A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	23-31
24391488-1	2014	Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	116-124
27266727-2	2016	In sepsis-induced AKI, there is a complex interplay between positive and negative regulation of HEPC, with consequently altered distributions of iron caused by changes in HEPC levels.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	96-100
24391488-1	2014	Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	116-124
26766967-1	2014	BACKGROUND: Hepcidin is a small secreted peptide that plays a key role in iron metabolism.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	12-20
27266727-2	2016	In sepsis-induced AKI, there is a complex interplay between positive and negative regulation of HEPC, with consequently altered distributions of iron caused by changes in HEPC levels.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	171-175
27746629-7	2016	In Peli1 knock-out a higher degree of antigen presentation, increased activity of adaptive and innate immune cells and alterations to proteins involved in iron metabolism were observed during experimental autoimmune encephalomyelitis.	Iron	155-159	pellino 1	Mus musculus	3-8
24507043-1	2014	Hepcidin is synthesized and secreted by liver cells and has been reported as one of the hormone molecules that regulates iron homeostasis.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	0-8
27714044-0	2016	Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells.	Iron	58-62	ATPase copper transporting alpha	Rattus norvegicus	13-41
24142925-6	2013	Molecular validation experiments pinpointed the iron metabolism factors AFT1, CCC1, and YAP5 as contributors to these molecular and cellular phenotypes; in genome-scale sequence analyses, a suite of iron toxicity response genes showed evidence for rapid protein evolution in Malaysian yeast.	Iron	48-52	Yap5p	Saccharomyces cerevisiae S288C	88-92
24142925-6	2013	Molecular validation experiments pinpointed the iron metabolism factors AFT1, CCC1, and YAP5 as contributors to these molecular and cellular phenotypes; in genome-scale sequence analyses, a suite of iron toxicity response genes showed evidence for rapid protein evolution in Malaysian yeast.	Iron	199-203	Yap5p	Saccharomyces cerevisiae S288C	88-92
27714044-0	2016	Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells.	Iron	58-62	ATPase copper transporting alpha	Rattus norvegicus	43-48
24195449-11	2013	Moreover, the (57)Fe Mossbauer spectrum of 4 at 80K exhibits parameters (delta = 0.43 mm s(-1); DeltaEQ = 1.37 mm s(-1)) which are consistent with a five-coordinate Fe(0) system, rendering 3 and 4 the first examples of well-defined authentic Fe(0)-eta(6)-arene complexes of the type [Fe(eta(6)-arene)L2] (L = eta(1 or 2) neutral ligand, mono or bidentate).	Iron	18-20	secreted phosphoprotein 1	Homo sapiens	309-319
24195449-11	2013	Moreover, the (57)Fe Mossbauer spectrum of 4 at 80K exhibits parameters (delta = 0.43 mm s(-1); DeltaEQ = 1.37 mm s(-1)) which are consistent with a five-coordinate Fe(0) system, rendering 3 and 4 the first examples of well-defined authentic Fe(0)-eta(6)-arene complexes of the type [Fe(eta(6)-arene)L2] (L = eta(1 or 2) neutral ligand, mono or bidentate).	Iron	165-167	secreted phosphoprotein 1	Homo sapiens	309-319
24195449-11	2013	Moreover, the (57)Fe Mossbauer spectrum of 4 at 80K exhibits parameters (delta = 0.43 mm s(-1); DeltaEQ = 1.37 mm s(-1)) which are consistent with a five-coordinate Fe(0) system, rendering 3 and 4 the first examples of well-defined authentic Fe(0)-eta(6)-arene complexes of the type [Fe(eta(6)-arene)L2] (L = eta(1 or 2) neutral ligand, mono or bidentate).	Iron	165-167	secreted phosphoprotein 1	Homo sapiens	309-319
27714044-12	2016	Expression of Dmt1 (the iron importer), Dcytb (an apical membrane ferrireductase) and Fpn1 (the iron exporter) was decreased in Atp7a knockdown (KD) cells.	Iron	24-28	doublesex and mab-3 related transcription factor 1	Homo sapiens	14-18
27469464-0	2016	Neurodegenerative disease: Lithium promotes accumulation of brain iron via tau suppression.	Iron	66-70	microtubule associated protein tau	Homo sapiens	75-78
24339866-8	2013	As upregulation of hepcidin by inflammation and iron status was blunted by erythropoietin in this population, enhanced iron absorption through the low hepcidin values may increase infection risk.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	19-27
24063264-0	2013	Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: in vitro and in vivo studies.	Iron	66-70	lactotransferrin	Rattus norvegicus	39-50
24063264-2	2013	Herein, deferasirox, a high affinity iron chelator, was conjugated to lactoferrin molecules by carbodiimide mediated coupling reaction to create a novel drug delivery system with higher brain permeability through receptor mediated transcytosis.	Iron	37-41	lactotransferrin	Rattus norvegicus	70-81
26975792-1	2016	Haemochromatosis is now known to be an iron-storage disease with genetic heterogeneity but with a final common metabolic pathway resulting in inappropriately low production of the hormone hepcidin.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	188-196
24245933-4	2013	The results demonstrate that Gd(3+)/[Fe(CN)6](3-) nanoparticles have r1p and r2p relaxivities about four times higher than the values observed in the same conditions for the commercial Contrast Agents (CAs) ProHance or Omniscan, regardless of the stabilizing agent used, while nanoparticles of Prussian blue and its analogues M(2+)/[Fe(CN)6](3-) (M = Ni, Cu, Fe) present relatively modest values.	Iron	37-39	CD1b molecule	Homo sapiens	69-72
24100161-7	2013	We also observed that CTH2, a gene involved in the mRNA degradation of several iron-containing enzymes, was induced upon Yfh1 depletion.	Iron	79-83	Tis11p	Saccharomyces cerevisiae S288C	22-26
27264950-1	2016	Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorption and reticuloendothelial sequestration of iron by interacting with ferroportin.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	0-8
27347716-4	2016	In this study, we found that mitophagy was induced under iron-depleted conditions, and that the disruption of a gene homologous to ATG32, which is responsible for mitophagy in Saccharomyces cerevisiae, blocked mitophagy in C. glabrata.	Iron	57-61	mitophagy protein ATG32	Saccharomyces cerevisiae S288C	131-136
24256246-4	2013	It has been suggested recently that alpha-synuclein is able to reduce iron using copper as its catalytic centre.	Iron	70-74	synuclein alpha	Homo sapiens	36-51
27235174-2	2016	Ceruloplasmin (Cp) and non-Cp ferroxidase activity might influence Hb production because of its role in modulating iron mobilization.	Iron	115-119	ceruloplasmin	Homo sapiens	0-13
23962817-5	2013	LFR1, LIT1 and LHR1 are upregulated under low iron availability, in agreement with the need to prevent excessive iron uptake.	Iron	46-50	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	6-10
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	ATP-binding cassette multidrug transporter PDR15	Saccharomyces cerevisiae S288C	297-302
23787477-1	2013	UNLABELLED: Human iron homeostasis is regulated by intestinal iron transport, hepatic hepcidin release, and signals from pathways that consume or supply iron.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	86-94
27377930-6	2016	When apo-lactoferrin (apo-LF) was administered to Ag-rats suffering from either post-hemorrhagic or hemolytic anemia, both hemoglobin and serum iron were restored more rapidly than in the control animals.	Iron	144-148	lactotransferrin	Rattus norvegicus	9-20
23787477-2	2013	The aim of this study was to characterize the adaptation of iron homeostasis under hypoxia in mountaineers at the levels of (1) hepatic hepcidin release, (2) intestinal iron transport, and (3) systemic inflammatory and erythropoietic responses.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	136-144
27262611-2	2016	However, recent data indicate that XPD, due to its iron-sulfur center interacts with the iron sulfur cluster assembly proteins, and may interact with other proteins in the cell to mediate a diverse set of biological functions including cell cycle regulation, mitosis, and mitochondrial function.	Iron	51-55	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	35-38
24089420-3	2013	Divalent metal transporter 1 (Dmt1), the predominant iron importer in the mammalian duodenum, also transports other metal ions, possibly including copper.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	0-28
24089420-3	2013	Divalent metal transporter 1 (Dmt1), the predominant iron importer in the mammalian duodenum, also transports other metal ions, possibly including copper.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	30-34
27117373-14	2016	In turn, endometriosis-related conditions, as iron overload and inflammation (IL-1beta), enhance endometriosis patients endometrial DMT1 expression, creating a vicious circle on DMT-1-modulated pathways.	Iron	46-50	solute carrier family 11 member 2	Homo sapiens	132-136
24089420-10	2013	Additional experiments in Dmt1 overexpressing HEK-293 cells showed that copper ((64)Cu) uptake was stimulated (~3-fold) in the presence of an iron chelator.	Iron	142-146	solute carrier family 11 member 2	Homo sapiens	26-30
27117373-14	2016	In turn, endometriosis-related conditions, as iron overload and inflammation (IL-1beta), enhance endometriosis patients endometrial DMT1 expression, creating a vicious circle on DMT-1-modulated pathways.	Iron	46-50	solute carrier family 11 member 2	Homo sapiens	178-183
27387771-6	2016	It was observed that spatiotemporal changes in intracellular labile iron, induced by H2O2, influenced the oxidation pattern of the upstream MAP3K ASK1 and promoted the sustained activation of JNK-p38 axis in a defined time-dependent context.	Iron	68-72	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	140-145
24126888-5	2013	Iron overload also led to induction of unfolded protein response (XBP1 splicing, activation of IRE-1alpha and PERK, as well as sequestration of GRP78) and ER stress (increased CHOP protein expression) following HFD and ethanol.	Iron	0-4	DNA-damage inducible transcript 3	Mus musculus	176-180
24065548-0	2013	Protective effect of mitochondrial ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells.	Iron	57-61	ferritin mitochondrial	Homo sapiens	21-43
24065548-2	2013	Mitochondria are involved in iron trafficking and mitochondrial ferritin (FtMt) was shown to provide protection against cellular iron imbalance.	Iron	129-133	ferritin mitochondrial	Homo sapiens	50-72
24065548-2	2013	Mitochondria are involved in iron trafficking and mitochondrial ferritin (FtMt) was shown to provide protection against cellular iron imbalance.	Iron	129-133	ferritin mitochondrial	Homo sapiens	74-78
27387771-6	2016	It was observed that spatiotemporal changes in intracellular labile iron, induced by H2O2, influenced the oxidation pattern of the upstream MAP3K ASK1 and promoted the sustained activation of JNK-p38 axis in a defined time-dependent context.	Iron	68-72	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	146-150
24065548-3	2013	Therefore, we hypothesized that FtMt overexpression could limit DOX effects on iron homeostasis.	Iron	79-83	ferritin mitochondrial	Homo sapiens	32-36
24065548-6	2013	Importantly, the ectopic expression of FtMt in human HeLa cells partially reverted DOX-induced iron imbalance.	Iron	95-99	ferritin mitochondrial	Homo sapiens	39-43
27418684-8	2016	Following administration of intravenous iron, values for ferritin concentration, transferrin saturation, and hepcidin concentration rose significantly (P &lt; 0.001, P &lt; 0.005, and P &lt; 0.001, respectively), and values for transferrin concentration fell significantly (P &lt; 0.001).	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	109-117
26758041-3	2016	Using double immunofluorescence and sequential iron and immunohistochemistry staining, we showed that marrow iron colocalizes with HO1 and H-ferritin to CD163 + macrophages.	Iron	109-113	heme oxygenase 1	Homo sapiens	131-134
24313519-1	2013	Motivated by the fully gapped superconductivity in iron-based superconductors with uncompensated electron pockets, we propose a spin singlet, but orbital triplet analogue of the superfluid phase of ^{3}He-B.	Iron	51-55	transcription factor 12	Homo sapiens	202-206
27428900-5	2016	We show that monocytes that express high levels of lymphocyte antigen 6 complex, locus C1 (LY6C1, also known as Ly-6C) ingest stressed and senescent erythrocytes, accumulate in the liver via coordinated chemotactic cues, and differentiate into ferroportin 1 (FPN1, encoded by SLC40A1)-expressing macrophages that can deliver iron to hepatocytes.	Iron	325-329	lymphocyte antigen 6 complex, locus C1	Mus musculus	51-89
24012860-1	2013	Iron (Fe) loaded solid lipid nanoparticles (SLN"s) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption.	Iron	0-4	sarcolipin	Homo sapiens	44-47
24012860-1	2013	Iron (Fe) loaded solid lipid nanoparticles (SLN"s) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption.	Iron	6-8	sarcolipin	Homo sapiens	44-47
24012860-2	2013	Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed between initial iron concentration and SLN iron incorporation efficiency.	Iron	0-4	sarcolipin	Homo sapiens	126-129
24012860-2	2013	Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed between initial iron concentration and SLN iron incorporation efficiency.	Iron	103-107	sarcolipin	Homo sapiens	126-129
27428900-5	2016	We show that monocytes that express high levels of lymphocyte antigen 6 complex, locus C1 (LY6C1, also known as Ly-6C) ingest stressed and senescent erythrocytes, accumulate in the liver via coordinated chemotactic cues, and differentiate into ferroportin 1 (FPN1, encoded by SLC40A1)-expressing macrophages that can deliver iron to hepatocytes.	Iron	325-329	lymphocyte antigen 6 complex, locus C1	Mus musculus	91-96
24012860-2	2013	Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed between initial iron concentration and SLN iron incorporation efficiency.	Iron	130-134	sarcolipin	Homo sapiens	126-129
24012860-7	2013	Caco-2 iron absorption from SLN-FeA (583.98+-40.83 ng/mg cell protein) and chitosan containing SLN-Fe-ChiB (642.77+-29.37 ng/mg cell protein) were 13.42% and 24.9% greater than that from ferrous sulphate (FeSO4) reference (514.66+-20.43 ng/mg cell protein) (p&lt;=0.05).	Iron	7-11	sarcolipin	Homo sapiens	28-31
27428900-5	2016	We show that monocytes that express high levels of lymphocyte antigen 6 complex, locus C1 (LY6C1, also known as Ly-6C) ingest stressed and senescent erythrocytes, accumulate in the liver via coordinated chemotactic cues, and differentiate into ferroportin 1 (FPN1, encoded by SLC40A1)-expressing macrophages that can deliver iron to hepatocytes.	Iron	325-329	lymphocyte antigen 6 complex, locus C1	Mus musculus	112-117
24012860-8	2013	We demonstrate for the first time preparation, characterisation and superior iron absorption in vitro from SLN"s, suggesting the potential of these formulations as a novel system for oral iron delivery.	Iron	77-81	sarcolipin	Homo sapiens	107-110
24012860-8	2013	We demonstrate for the first time preparation, characterisation and superior iron absorption in vitro from SLN"s, suggesting the potential of these formulations as a novel system for oral iron delivery.	Iron	188-192	sarcolipin	Homo sapiens	107-110
27428900-7	2016	The spleen, likewise, recruits iron-loaded Ly-6C(high) monocytes, but these do not differentiate into iron-recycling macrophages, owing to the suppressive action of Csf2.	Iron	31-35	lymphocyte antigen 6 complex, locus C1	Mus musculus	43-48
26950401-1	2016	BACKGROUND AND OBJECTIVES: Chronic inflammation can lead to anaemia of chronic disease due to the sequestration of iron caused by inflammatory cytokines and the protein hepcidin.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	169-177
24194187-10	2013	Hypoxia (24 hours) decreased uptake of iron from transferrin but not from FeCl3.	Iron	39-43	inhibitor of carbonic anhydrase	Canis lupus familiaris	49-60
27411564-0	2016	A double blind randomised controlled trial comparing standard dose of iron supplementation for pregnant women with two screen-and-treat approaches using hepcidin as a biomarker for ready and safe to receive iron.	Iron	207-211	hepcidin antimicrobial peptide	Homo sapiens	153-161
24089531-3	2013	The extrinsic arm contains binding sites for NADH and the primary electron acceptor FMN, and it provides a scaffold for seven iron-sulfur clusters that form an electron pathway linking FMN to the terminal electron acceptor, ubiquinone, which is bound in the region of the junction between the arms.	Iron	126-130	formin 1	Homo sapiens	84-87
24089531-3	2013	The extrinsic arm contains binding sites for NADH and the primary electron acceptor FMN, and it provides a scaffold for seven iron-sulfur clusters that form an electron pathway linking FMN to the terminal electron acceptor, ubiquinone, which is bound in the region of the junction between the arms.	Iron	126-130	formin 1	Homo sapiens	185-188
24244576-13	2013	CONCLUSION: Iron metabolism is distorted in advanced HIV infection with CD4 cell counts correlating inversely with serum hepcidin levels.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	121-129
27411564-5	2016	Here, we test the use of hepcidin a peptide hormone and key regulator of iron metabolism, as a potential index for "safe and ready to receive" iron.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	25-33
24228190-0	2013	Iron biology, immunology, aging, and obesity: four fields connected by the small peptide hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	97-105
24228190-5	2013	Hepcidin, a peptide hormone that regulates cellular iron export, is essential for the maintenance of iron homeostasis.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
24228190-5	2013	Hepcidin, a peptide hormone that regulates cellular iron export, is essential for the maintenance of iron homeostasis.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	0-8
27411564-5	2016	Here, we test the use of hepcidin a peptide hormone and key regulator of iron metabolism, as a potential index for "safe and ready to receive" iron.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	25-33
24228190-6	2013	Therefore, since immune cells require iron for proper function hepcidin may also play an important role in immune response.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	63-71
27411564-7	2016	We will test the hypothesis that a screen-and-treat approach to iron supplementation using a pre-determined hepcidin cut-off value of &lt;2.5 ng/ml will achieve similar efficacy in preventing iron deficiency and anaemia at a lower iron dose and hence will improve safety.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	108-116
24228190-7	2013	In this review, we summarize the evidence for hepcidin as a link between the fields of gerontology, obesity, iron biology, and immunology.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	46-54
27411564-13	2016	The potential for the use of hepcidin for a simple point-of-care (PoC) diagnostic for when it is most safe and effective to give iron may improve maternal health outcomes.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	29-37
27226634-3	2016	The extrinsic arm contains binding sites for NADH, the primary electron acceptor FMN, and seven iron-sulfur clusters that form a pathway for electrons linking FMN to the terminal electron acceptor, ubiquinone, which is bound in a tunnel in the region of the junction between the arms.	Iron	96-100	formin 1	Homo sapiens	159-162
24511683-0	2013	[The effect of exogenous antioxidants on the antioxidant status of erythrocytes and hepcidin content in blood of patients with disorders of iron metabolism regulation].	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	84-92
27282576-10	2016	Further experiments and clinical studies in other groups of patients are needed to better elucidate the role of Hepcidin-25 and sTfR/Hepcidin-25 ratio as predictors of response to intravenous iron administration.	Iron	192-196	hepcidin antimicrobial peptide	Homo sapiens	133-141
27737394-0	2016	Hepcidin: an important iron metabolism regulator in chronic kidney disease.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
23943237-2	2013	Mutations in the FPN gene (SLC40A1) lead to autosomal dominant iron overload diseases related either to loss or to gain of function, and usually characterized by normal or low transferrin saturation versus elevated transferrin saturation, respectively.	Iron	63-67	solute carrier family 40 member 1	Homo sapiens	27-34
24218134-1	2013	BACKGROUND: Hepcidin-25 regulates iron homeostasis by binding the iron transporter ferroportin, causing its degradation.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	12-20
27737394-3	2016	Hepcidin is a peptide mainly produced by hepatocytes and, through a connection with ferroportin, it regulates iron absorption in the duodenum and its release of stock cells.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	0-8
24218134-2	2013	Increased hepcidin-25 causes decreased intestinal iron absorption and release from intracellular stores.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	10-18
27129231-3	2016	Bone morphogenetic protein 6 (BMP6) contributes to the iron-dependent control of hepcidin.	Iron	55-59	bone morphogenetic protein 6	Mus musculus	0-28
27129231-3	2016	Bone morphogenetic protein 6 (BMP6) contributes to the iron-dependent control of hepcidin.	Iron	55-59	bone morphogenetic protein 6	Mus musculus	30-34
27129231-11	2016	In conclusion, these data demonstrate that a complex regulatory network involving TGF-beta1 and BMP6 may control the sensing of systemic and/or hepatic iron levels.	Iron	152-156	bone morphogenetic protein 6	Mus musculus	96-100
24159166-0	2013	Anti-hepcidin therapy for iron-restricted anemias.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	5-13
27283533-4	2016	Although the antioxidant and heat-shock proteins are included in this category, one enzyme that has received a great deal of attention as a master protective sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the catabolism of heme into the bioactive signaling molecules carbon monoxide, biliverdin, and iron.	Iron	316-320	heme oxygenase 1	Homo sapiens	170-186
24159166-1	2013	In this issue of Blood, Cooke et al demonstrate the potential of a fully human anti-hepcidin antibody as a novel therapeutic for iron-restricted anemias such as anemia of inflammation, cancer, or chronic kidney disease (formerly known as "anemia of chronic diseases").	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	84-92
24063668-5	2013	Moreover, IP1 can be used to identify reversible expansion of labile iron pools by stimulation with vitamin C or the iron regulatory hormone hepcidin, providing a starting point for further investigations of iron signaling and stress events in living systems as well as future probe development.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	141-149
24063668-5	2013	Moreover, IP1 can be used to identify reversible expansion of labile iron pools by stimulation with vitamin C or the iron regulatory hormone hepcidin, providing a starting point for further investigations of iron signaling and stress events in living systems as well as future probe development.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	141-149
24063668-5	2013	Moreover, IP1 can be used to identify reversible expansion of labile iron pools by stimulation with vitamin C or the iron regulatory hormone hepcidin, providing a starting point for further investigations of iron signaling and stress events in living systems as well as future probe development.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	141-149
27283533-4	2016	Although the antioxidant and heat-shock proteins are included in this category, one enzyme that has received a great deal of attention as a master protective sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the catabolism of heme into the bioactive signaling molecules carbon monoxide, biliverdin, and iron.	Iron	316-320	heme oxygenase 1	Homo sapiens	188-192
27044621-3	2016	Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	86-94
24007662-8	2013	The elevation of ferritin (FTL, FTH1) may indicate an iron-mediated oxidative imbalance aggravating the mitochondrial failure and neurotoxicity.	Iron	54-58	ferritin heavy chain 1	Homo sapiens	32-36
27044621-3	2016	Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	86-94
24138624-1	2013	BACKGROUND: Hepcidin, a 25 amino acid peptide, plays an important role in iron homeostasis.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	12-20
23771608-6	2013	In accordance with these iron traffic modulations, both mRNA and protein levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1+IRE) and exporter ferroportin 1 (FPN1) were up-regulated in these cells.	Iron	25-29	solute carrier family 11 member 2	Homo sapiens	156-164
26972048-0	2016	Iron gene expression profile in atherogenic Mox macrophages.	Iron	0-4	monooxygenase DBH like 1	Homo sapiens	44-47
23771608-6	2013	In accordance with these iron traffic modulations, both mRNA and protein levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1+IRE) and exporter ferroportin 1 (FPN1) were up-regulated in these cells.	Iron	25-29	solute carrier family 40 member 1	Homo sapiens	194-198
23771608-6	2013	In accordance with these iron traffic modulations, both mRNA and protein levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1+IRE) and exporter ferroportin 1 (FPN1) were up-regulated in these cells.	Iron	83-87	solute carrier family 11 member 2	Homo sapiens	156-164
26972048-3	2016	An important phenotypic population driven by oxidized phospholipids is the Mox macrophages which present unique biological properties but their iron phenotype is not well described.	Iron	144-148	monooxygenase DBH like 1	Homo sapiens	75-78
23703590-1	2013	UNLABELLED: Hepcidin, a peptide hormone that decreases intestinal iron absorption and macrophage iron release, is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	12-20
23703590-1	2013	UNLABELLED: Hepcidin, a peptide hormone that decreases intestinal iron absorption and macrophage iron release, is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	12-20
23703590-1	2013	UNLABELLED: Hepcidin, a peptide hormone that decreases intestinal iron absorption and macrophage iron release, is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	12-20
26972048-4	2016	OBJECTIVE: To investigate the effect of Mox polarization by oxidized LDL (oxLDL) on macrophage iron metabolism in the absence or presence of proinflammatory stimuli.	Iron	95-99	monooxygenase DBH like 1	Homo sapiens	40-43
26972048-10	2016	The downregulation of both Cp isoforms and the upregulation of Hamp expression observed in Mox macrophages suggest that FPN mediated iron export could be compromised.	Iron	133-137	monooxygenase DBH like 1	Homo sapiens	91-94
27441542-8	2016	Based on the results, it can be concluded that the use of rEPO in complex therapy of beta-thalassemia intermedia leads to increased levels of Hb and consequently reducing the need for blood transfusions, and accordingly expected to prevent severe complications of blood transfusion (alloimmunization, hypersplenism, iron overload, contamination transmissible infections) facilitating normal growth and development, and a better quality of life.	Iron	316-320	erythropoietin	Rattus norvegicus	58-62
23784628-1	2013	Ferroportin (SLC40A1) is the only known iron exporter in mammals and is considered a key coordinator of the iron balance between intracellular and systemic iron homeostasis.	Iron	40-44	solute carrier family 40 member 1	Homo sapiens	13-20
23784628-1	2013	Ferroportin (SLC40A1) is the only known iron exporter in mammals and is considered a key coordinator of the iron balance between intracellular and systemic iron homeostasis.	Iron	108-112	solute carrier family 40 member 1	Homo sapiens	13-20
23784628-1	2013	Ferroportin (SLC40A1) is the only known iron exporter in mammals and is considered a key coordinator of the iron balance between intracellular and systemic iron homeostasis.	Iron	108-112	solute carrier family 40 member 1	Homo sapiens	13-20
23784628-6	2013	In particular, we show that the tryptophan residue 42 (p.Trp42), which is localized within the extracellular end of the ferroportin pore, is likely involved in both the iron export function and in the mechanism of inhibition by hepcidin.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	228-236
26755707-1	2016	Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts.	Iron	32-36	erythropoietin	Mus musculus	108-122
23850497-1	2013	Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that is induced by intraplaque hemorrhage and degrades free heme and releases ferrous iron, which is rapidly sequestered by ferritin.	Iron	137-141	heme oxygenase 1	Homo sapiens	0-16
23850497-1	2013	Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that is induced by intraplaque hemorrhage and degrades free heme and releases ferrous iron, which is rapidly sequestered by ferritin.	Iron	137-141	heme oxygenase 1	Homo sapiens	18-22
26755707-1	2016	Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts.	Iron	32-36	erythropoietin	Mus musculus	124-127
26755707-1	2016	Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts.	Iron	138-142	erythropoietin	Mus musculus	108-122
23910348-4	2013	In such a bi-nanometal-grown multi-scale web of ACF/CNF, Cu nanoparticles adhere to the ACF-surface, whereas Fe nanoparticles used to catalyze the growth of nanofibers attach to the CNF tips.	Iron	109-111	ACF	Homo sapiens	48-51
26755707-1	2016	Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts.	Iron	138-142	erythropoietin	Mus musculus	124-127
27433157-4	2016	Here, we show that a mitochondrial iron transporter, MrsA, a homolog of yeast Mrs4p, is critical for adaptation to iron-limited or iron-excess conditions in A. fumigatus.	Iron	35-39	Fe(2+) transporter	Saccharomyces cerevisiae S288C	78-83
24127501-2	2013	In obese patients, elevated cytokine production stimulates hepcidin synthesis, causing iron to be retained as ferritin in e.g. macrophages (functional iron deficiency).	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	59-67
27433157-4	2016	Here, we show that a mitochondrial iron transporter, MrsA, a homolog of yeast Mrs4p, is critical for adaptation to iron-limited or iron-excess conditions in A. fumigatus.	Iron	115-119	Fe(2+) transporter	Saccharomyces cerevisiae S288C	78-83
26969708-0	2016	Soybean Ferritin Expression in Saccharomyces cerevisiae Modulates Iron Accumulation and Resistance to Elevated Iron Concentrations.	Iron	66-70	ferritin-1, chloroplastic	Glycine max	8-16
23888876-1	2013	Hepcidin is a peptide hormone that regulates homeostasis in iron metabolism.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
26969708-0	2016	Soybean Ferritin Expression in Saccharomyces cerevisiae Modulates Iron Accumulation and Resistance to Elevated Iron Concentrations.	Iron	111-115	ferritin-1, chloroplastic	Glycine max	8-16
26969708-2	2016	This work explored how plant ferritin expression influenced baker"s yeast iron metabolism.	Iron	74-78	ferritin-1, chloroplastic	Glycine max	29-37
23811518-4	2013	The analyses of 16S rRNA, cbbM, and pmoA genes strongly suggested the coexistence of autotrophic iron oxidizers and methanotrophs in the flocs.	Iron	97-101	opsin 1, medium wave sensitive	Homo sapiens	26-30
26969708-5	2016	Soybean ferritin protected yeast cells that lacked the Ccc1 vacuolar iron detoxification transporter from toxic iron levels by reducing cellular oxidation, thus allowing growth at high iron concentrations.	Iron	69-73	ferritin-1, chloroplastic	Glycine max	8-16
26969708-5	2016	Soybean ferritin protected yeast cells that lacked the Ccc1 vacuolar iron detoxification transporter from toxic iron levels by reducing cellular oxidation, thus allowing growth at high iron concentrations.	Iron	112-116	ferritin-1, chloroplastic	Glycine max	8-16
23897622-1	2013	The peptide hormone hepcidin is a key regulator of iron homeostasis in vertebrates.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	20-28
23897622-2	2013	Hepcidin acts by binding to ferroportin, the sole known iron exporter, causing it to be internalized and thus trapping iron within the cell.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
26969708-6	2016	Interestingly, when simultaneously expressed in ccc1Delta cells, SFerH1 and SFerH2 assembled as heteropolymers, which further increased iron resistance and reduced the oxidative stress produced by excess iron compared to ferritin homopolymer complexes.	Iron	136-140	ferritin-1, chloroplastic	Glycine max	65-71
23897622-2	2013	Hepcidin acts by binding to ferroportin, the sole known iron exporter, causing it to be internalized and thus trapping iron within the cell.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	0-8
23897622-3	2013	Dysregulation of hepcidin concentrations is associated with a range of iron-related diseases and hepcidin-based therapeutics could be developed as candidate treatments for these diseases.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	17-25
26969708-6	2016	Interestingly, when simultaneously expressed in ccc1Delta cells, SFerH1 and SFerH2 assembled as heteropolymers, which further increased iron resistance and reduced the oxidative stress produced by excess iron compared to ferritin homopolymer complexes.	Iron	204-208	ferritin-1, chloroplastic	Glycine max	65-71
23794717-4	2013	We report here the second study to investigate the role of hepcidin in the associations between common variants in HFE and TMPRSS6 with iron parameters.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	59-67
26969708-7	2016	Finally, soybean ferritin expression led to increased iron accumulation in both wild-type and ccc1Delta yeast cells at certain environmental iron concentrations.	Iron	54-58	ferritin-1, chloroplastic	Glycine max	17-25
26969708-7	2016	Finally, soybean ferritin expression led to increased iron accumulation in both wild-type and ccc1Delta yeast cells at certain environmental iron concentrations.	Iron	130-134	ferritin-1, chloroplastic	Glycine max	17-25
26969708-11	2016	Animals and plants possess large ferritin complexes that accumulate, detoxify, or buffer excess cellular iron.	Iron	105-109	ferritin-1, chloroplastic	Glycine max	33-41
26969708-13	2016	Here, we explored how soybean ferritin expression influenced yeast iron metabolism, confirming that yeasts that express soybean seed ferritin could be explored as a novel strategy to increase dietary iron absorption.	Iron	67-71	ferritin-1, chloroplastic	Glycine max	30-38
23338780-2	2013	Because ceruloplasmin is the major circulating ferroxidase, iron metabolism may be affected in patients with WD.	Iron	60-64	ceruloplasmin	Homo sapiens	8-21
26969708-13	2016	Here, we explored how soybean ferritin expression influenced yeast iron metabolism, confirming that yeasts that express soybean seed ferritin could be explored as a novel strategy to increase dietary iron absorption.	Iron	200-204	ferritin-1, chloroplastic	Glycine max	30-38
26969708-13	2016	Here, we explored how soybean ferritin expression influenced yeast iron metabolism, confirming that yeasts that express soybean seed ferritin could be explored as a novel strategy to increase dietary iron absorption.	Iron	200-204	ferritin-1, chloroplastic	Glycine max	133-141
26929401-2	2016	Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion.	Iron	220-224	suppression inducing transmembrane adaptor 1	Mus musculus	50-54
23909493-1	2013	Phytoferritin from legume seeds is naturally compartmentalized in amyloplasts, where iron is takem up and released by ferritin during seed formation and germination.	Iron	85-89	ferritin-1, chloroplastic	Glycine max	5-13
23909493-3	2013	No starch damage was visualized by SEM during iron uptake by apo soybean seed ferritin (SSF).	Iron	46-50	ferritin-1, chloroplastic	Glycine max	78-86
26929401-2	2016	Recently, we identified the membrane transporters sit1 and sit2, which are putative virulence factors of A. fumigatus; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion.	Iron	220-224	suppression inducing transmembrane adaptor 1	Mus musculus	119-123
23986768-3	2013	Previous results in Fe-deficient cucumber roots showed that high H(+) extrusion is accompanied by increased phosphoenolpyruvate carboxylase (PEPC) activity, involved in the cytosol pH-stat; moreover (31)P-NMR analysis revealed increased vacuolar pH and decreased vacuolar [inorganic phosphate (Pi)].	Iron	20-22	phosphoenolpyruvate carboxylase	Glycine max	141-145
26929401-5	2016	Both sit1 and sit2 were localized to the plasma membrane in A. fumigatus The expression levels of the sit1 and sit2 genes were dependent on hapX under low-but not high-iron conditions.	Iron	168-172	suppression inducing transmembrane adaptor 1	Mus musculus	5-9
26929401-5	2016	Both sit1 and sit2 were localized to the plasma membrane in A. fumigatus The expression levels of the sit1 and sit2 genes were dependent on hapX under low-but not high-iron conditions.	Iron	168-172	suppression inducing transmembrane adaptor 1	Mus musculus	102-106
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	287-291	hepcidin antimicrobial peptide	Homo sapiens	236-244
23940258-6	2013	Increased iron incorporation into the FtH homopolymer leads to reduced cellular iron availability, diminished levels of cytosolic catalase, SOD1 protein levels, enhanced ROS production and higher levels of oxidized proteins.	Iron	10-14	ferritin heavy chain 1	Homo sapiens	38-41
23941109-4	2013	Moreover, BDH2 catalyzes the production of 2, 3-DHBA during enterobactin biosynthesis and participates in 24p3 (LCN2)-mediated iron transport and apoptosis.	Iron	127-131	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	10-14
27067488-0	2016	EPO-dependent induction of erythroferrone drives hepcidin suppression and systematic iron absorption under phenylhydrazine-induced hemolytic anemia.	Iron	85-89	erythropoietin	Mus musculus	0-3
23798678-6	2013	Nbp35 readily bound (55)Fe when fed to cells, whereas (55)Fe binding by free Cfd1 could not be detected.	Iron	24-26	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	0-5
27067488-8	2016	Thus, our data unearthed EPO-dependent ERFE expression acts as an erythropoiesis-driven regulator of iron metabolism under PHZ-induced hemolytic anemia.	Iron	101-105	erythropoietin	Mus musculus	25-28
23445875-1	2013	Dietary iron absorption is regulated by hepcidin, an iron regulatory protein produced by the liver.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	40-48
28303071-6	2016	The liver has emerged as the major site of systemic iron regulation, being the location where the iron regulatory hormone hepcidin is produced.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	122-130
23445875-2	2013	Hepcidin production is regulated by iron stores, erythropoiesis and inflammation, but its physiology when repeated blood loss occurs has not been characterized.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
23445875-8	2013	In conclusion, hepcidin levels change rapidly in response to dietary iron needed for erythropoiesis.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	15-23
23445875-9	2013	The dynamic regulation of hepcidin in the presence of a low levels of ferritin suggests that plasma hepcidin concentration may provide clinically useful information about an individual"s iron status (and hence capacity to tolerate repeated blood donations) beyond that of ferritin alone.	Iron	187-191	hepcidin antimicrobial peptide	Homo sapiens	100-108
28303071-6	2016	The liver has emerged as the major site of systemic iron regulation, being the location where the iron regulatory hormone hepcidin is produced.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	122-130
23663300-1	2013	The effect of high-pressure treatment (400, 500 and 650 MPa) on the structure and activity of bovine lactoferrin in different iron-saturation forms has been studied by several techniques.	Iron	126-130	lactotransferrin	Bos taurus	101-112
28303071-7	2016	Hepcidin is a negative regulator of iron absorption and recycling, achieving this by binding to the only known cellular iron exporter ferroportin and causing its internalisation and degradation, thereby reducing iron efflux from target cells and reducing serum iron levels.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
28303071-7	2016	Hepcidin is a negative regulator of iron absorption and recycling, achieving this by binding to the only known cellular iron exporter ferroportin and causing its internalisation and degradation, thereby reducing iron efflux from target cells and reducing serum iron levels.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	0-8
28303071-7	2016	Hepcidin is a negative regulator of iron absorption and recycling, achieving this by binding to the only known cellular iron exporter ferroportin and causing its internalisation and degradation, thereby reducing iron efflux from target cells and reducing serum iron levels.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	0-8
23723143-0	2013	Adiponectin ameliorates iron-overload cardiomyopathy through the PPARalpha-PGC-1-dependent signaling pathway.	Iron	24-28	adiponectin, C1Q and collagen domain containing	Mus musculus	0-11
23723143-3	2013	Therefore, we aimed to investigate whether adiponectin would have a beneficial effect in iron-induced chronic heart failure and to elucidate its regulation in cardiomyocytes.	Iron	89-93	adiponectin, C1Q and collagen domain containing	Mus musculus	43-54
28303071-7	2016	Hepcidin is a negative regulator of iron absorption and recycling, achieving this by binding to the only known cellular iron exporter ferroportin and causing its internalisation and degradation, thereby reducing iron efflux from target cells and reducing serum iron levels.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	0-8
23723143-6	2013	In vivo cardiac adiponectin gene (ADIPOQ) overexpression with adenoassociated virus (AAV)-ADIPOQ ameliorated cardiac iron deposition and restored cardiac function in iron-overloaded mice.	Iron	117-121	adiponectin, C1Q and collagen domain containing	Mus musculus	16-27
23723143-6	2013	In vivo cardiac adiponectin gene (ADIPOQ) overexpression with adenoassociated virus (AAV)-ADIPOQ ameliorated cardiac iron deposition and restored cardiac function in iron-overloaded mice.	Iron	117-121	adiponectin, C1Q and collagen domain containing	Mus musculus	34-40
28303071-8	2016	Much of the research in the iron metabolism field has focussed on the regulation of hepcidin and its interaction with ferroportin.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	84-92
23723143-6	2013	In vivo cardiac adiponectin gene (ADIPOQ) overexpression with adenoassociated virus (AAV)-ADIPOQ ameliorated cardiac iron deposition and restored cardiac function in iron-overloaded mice.	Iron	117-121	adiponectin, C1Q and collagen domain containing	Mus musculus	90-96
23723143-6	2013	In vivo cardiac adiponectin gene (ADIPOQ) overexpression with adenoassociated virus (AAV)-ADIPOQ ameliorated cardiac iron deposition and restored cardiac function in iron-overloaded mice.	Iron	166-170	adiponectin, C1Q and collagen domain containing	Mus musculus	16-27
27091216-9	2016	It is therefore tempting to postulate that the main pathophysiological pathway leading to these events may involve the pleiotropic master hormone hepcidin (synergized by fibroblast growth factor 23), which regulates iron metabolism.	Iron	216-220	hepcidin antimicrobial peptide	Homo sapiens	146-154
23723143-6	2013	In vivo cardiac adiponectin gene (ADIPOQ) overexpression with adenoassociated virus (AAV)-ADIPOQ ameliorated cardiac iron deposition and restored cardiac function in iron-overloaded mice.	Iron	166-170	adiponectin, C1Q and collagen domain containing	Mus musculus	34-40
23723143-6	2013	In vivo cardiac adiponectin gene (ADIPOQ) overexpression with adenoassociated virus (AAV)-ADIPOQ ameliorated cardiac iron deposition and restored cardiac function in iron-overloaded mice.	Iron	166-170	adiponectin, C1Q and collagen domain containing	Mus musculus	90-96
23723143-7	2013	In addition, AAV-ADIPOQ-treated iron-overload mice had lower expression of inflammatory markers, including myeloperoxidase activity, monocyte chemotactic protein-1, tumor necrosis factor-alpha, interleukin-6, and intercellular adhesion molecule-1, than iron-overloaded mice not treated with AAV-ADIPOQ.	Iron	32-36	adiponectin, C1Q and collagen domain containing	Mus musculus	17-23
23723143-7	2013	In addition, AAV-ADIPOQ-treated iron-overload mice had lower expression of inflammatory markers, including myeloperoxidase activity, monocyte chemotactic protein-1, tumor necrosis factor-alpha, interleukin-6, and intercellular adhesion molecule-1, than iron-overloaded mice not treated with AAV-ADIPOQ.	Iron	32-36	adiponectin, C1Q and collagen domain containing	Mus musculus	295-301
23723143-7	2013	In addition, AAV-ADIPOQ-treated iron-overload mice had lower expression of inflammatory markers, including myeloperoxidase activity, monocyte chemotactic protein-1, tumor necrosis factor-alpha, interleukin-6, and intercellular adhesion molecule-1, than iron-overloaded mice not treated with AAV-ADIPOQ.	Iron	253-257	adiponectin, C1Q and collagen domain containing	Mus musculus	17-23
23723143-9	2013	Furthermore, the adiponectin-mediated beneficial effects were PPARalpha-dependent as the adiponectin-mediated attenuation of iron deposition was abolished in PPARalpha-knockout mice.	Iron	125-129	adiponectin, C1Q and collagen domain containing	Mus musculus	17-28
23723143-9	2013	Furthermore, the adiponectin-mediated beneficial effects were PPARalpha-dependent as the adiponectin-mediated attenuation of iron deposition was abolished in PPARalpha-knockout mice.	Iron	125-129	adiponectin, C1Q and collagen domain containing	Mus musculus	89-100
23723143-11	2013	Together, these findings suggest that adiponectin acts as an anti-inflammatory signaling molecule and induces the expression of HO-1 through the PPARalpha-PGC-1 complex-dependent pathway in cardiomyocytes, resulting in the attenuation of iron-induced cardiomyopathy.	Iron	238-242	adiponectin, C1Q and collagen domain containing	Mus musculus	38-49
23723143-12	2013	Using adiponectin for adjuvant therapies in iron-overload cardiac dysfunction may be an option in the future.	Iron	44-48	adiponectin, C1Q and collagen domain containing	Mus musculus	6-17
27071088-3	2016	Using inductively coupled plasma mass spectrometry, X-ray absorption spectroscopy, and UV-visible spectroscopy, we report that CPSF30 is isolated with iron, in addition to zinc.	Iron	151-155	cleavage and polyadenylation specific factor 4	Homo sapiens	127-133
24199884-7	2013	The logistic regression analysis showed that anuria (OR 0.292, 95%CI 0.114-0.750) and beta2 microglobulin (OR 1.023, 95%CI 1.003-1.044) were the risk factors for RLS in the maintenance hemodialysis patients, while hemoglobin, serum iron and parathyroid hormone were not correlated with RLS.	Iron	232-236	beta-2-microglobulin	Homo sapiens	86-105
23903042-2	2013	Recent studies in Saccharomyces cerevisiae have shown that in response to iron deficiency, an RNA-binding protein denoted Cth2 coordinates a global metabolic rearrangement that aims to optimize iron utilization.	Iron	74-78	Tis11p	Saccharomyces cerevisiae S288C	122-126
27071088-4	2016	Iron is present in CPSF30 as a 2Fe-2S cluster and uses one of the Cys3His domains; 2Fe-2S clusters with a Cys3His ligand set are rare and notably have also been identified in MitoNEET, a protein that was also annotated as a zinc finger.	Iron	0-4	cleavage and polyadenylation specific factor 4	Homo sapiens	19-25
27071088-4	2016	Iron is present in CPSF30 as a 2Fe-2S cluster and uses one of the Cys3His domains; 2Fe-2S clusters with a Cys3His ligand set are rare and notably have also been identified in MitoNEET, a protein that was also annotated as a zinc finger.	Iron	0-4	CDGSH iron sulfur domain 1	Homo sapiens	175-183
26712506-8	2016	Transcript levels of CBR1, fatty acids desaturase2 (FAD2), and fatty acids desaturase3 (FAD3) were increased under Fe-deficient conditions.	Iron	115-117	fatty acid desaturase 2	Arabidopsis thaliana	52-56
23898337-4	2013	This review focuses on the new actors discovered in the past few years, such as glutaredoxin, BOLA and NEET proteins as well as MIP18, MMS19, TAH18, DRE2 for the cytosolic machinery, which are integrated into a model for the plant Fe-S cluster biogenesis systems.	Iron	231-235	cytosolic iron-sulfur assembly component 2B	Homo sapiens	128-133
23687303-0	2013	Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress.	Iron	118-122	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	9-38
23687303-2	2013	The aim of this work was to investigate the participation of the PI3K/Akt pathway and its outcome on different molecular targets such as glycogen synthase kinase 3beta (GSK3beta) and Forkhead box-O (FoxO) transcription factors during mild oxidative stress triggered by iron overload.	Iron	269-273	glycogen synthase kinase 3 beta	Mus musculus	137-167
26712506-8	2016	Transcript levels of CBR1, fatty acids desaturase2 (FAD2), and fatty acids desaturase3 (FAD3) were increased under Fe-deficient conditions.	Iron	115-117	fatty acid desaturase 3	Arabidopsis thaliana	88-92
23687303-9	2013	Our results show that activation of the PI3K/Akt pathway during iron-induced neurotoxicity regulates multiple targets such as GSK3beta, FoxO transcriptional activity, and glutathione metabolism, thus modulating the neuronal response to oxidative stress.	Iron	64-68	glycogen synthase kinase 3 beta	Mus musculus	126-134
27442696-1	2016	Lactoferrin is an iron-binding glycoprotein, which is present in most biological fluids with particularly high levels in colostrum and in mammalian milk.	Iron	18-22	lactotransferrin	Bos taurus	0-11
23580428-1	2013	Chronic viral hepatitis C is characterized by iron accumulation in the liver, and hepcidin regulates iron absorption.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	82-90
27057839-0	2016	Hepcidin: A Promising Therapeutic Target for Iron Disorders: A Systematic Review.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
23580428-6	2013	In conclusion, we provide evidence that core+1/ARFP downregulates AP1-mediated transcription, providing new insights into the biological role of core+1/ARFP, as well as the transcriptional modulation of hepcidin, the main regulator of iron metabolism.	Iron	235-239	hepcidin antimicrobial peptide	Homo sapiens	203-211
27057839-3	2016	Hepcidin (encoded by Hamp gene) is a peptide hormone synthesized by hepatocytes, and it plays an important role in regulating the systematic iron homeostasis.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	0-8
27057839-3	2016	Hepcidin (encoded by Hamp gene) is a peptide hormone synthesized by hepatocytes, and it plays an important role in regulating the systematic iron homeostasis.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	21-25
27057839-4	2016	As the systemic iron regulator, hepcidin, not only controls dietary iron absorption and iron egress out of iron storage cells, but also induces iron redistribution in various organs.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	32-40
23468534-3	2013	In addition, pro-inflammatory cytokines stimulate hepcidin synthesis thus reducing iron availability for late erythropoiesis.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	50-58
27057839-4	2016	As the systemic iron regulator, hepcidin, not only controls dietary iron absorption and iron egress out of iron storage cells, but also induces iron redistribution in various organs.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	32-40
27057839-4	2016	As the systemic iron regulator, hepcidin, not only controls dietary iron absorption and iron egress out of iron storage cells, but also induces iron redistribution in various organs.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	32-40
27057839-4	2016	As the systemic iron regulator, hepcidin, not only controls dietary iron absorption and iron egress out of iron storage cells, but also induces iron redistribution in various organs.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	32-40
27057839-4	2016	As the systemic iron regulator, hepcidin, not only controls dietary iron absorption and iron egress out of iron storage cells, but also induces iron redistribution in various organs.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	32-40
23785377-8	2013	We have shown that the soybean ferritin transgene affected the expression of native iron homeostasis genes in the maize plant.	Iron	84-88	ferritin-1, chloroplastic	Glycine max	31-39
27057839-5	2016	Deregulated hepcidin is often seen in a variety of iron-related diseases including anemias and iron overload disorders.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	12-20
27057839-6	2016	In the case of iron overload disorders (e.g., hereditary hemochromatosis and beta-thalassemia), hepatic hepcidin concentration is significantly reduced.Since hepcidin deregulation is responsible for iron disorder-associated diseases, the purpose of this review is to summarize the recent findings on therapeutics targeting hepcidin.Continuous efforts have been made to search for hepcidin mimics and chemical compounds that could be used to increase hepcidin level.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	104-112
27057839-6	2016	In the case of iron overload disorders (e.g., hereditary hemochromatosis and beta-thalassemia), hepatic hepcidin concentration is significantly reduced.Since hepcidin deregulation is responsible for iron disorder-associated diseases, the purpose of this review is to summarize the recent findings on therapeutics targeting hepcidin.Continuous efforts have been made to search for hepcidin mimics and chemical compounds that could be used to increase hepcidin level.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	158-166
23776592-3	2013	Moreover, two ferroxidase proteins involved in iron homeostasis, hephaestin expressed in enterocytes and ceruloplasmin, produced and secreted into blood by the liver, are copper-dependent enzymes.	Iron	47-51	ceruloplasmin	Mus musculus	14-25
23776592-3	2013	Moreover, two ferroxidase proteins involved in iron homeostasis, hephaestin expressed in enterocytes and ceruloplasmin, produced and secreted into blood by the liver, are copper-dependent enzymes.	Iron	47-51	ceruloplasmin	Mus musculus	105-118
23776592-10	2013	Conversely, upregulation of iron absorption was associated with increased enterocyte and liver copper levels and serum ferroxidase (ceruloplasmin) activity in Mo (Br) (/y) mice, typifying the response to iron deprivation in many mammalian species.	Iron	28-32	ceruloplasmin	Mus musculus	119-130
23776592-10	2013	Conversely, upregulation of iron absorption was associated with increased enterocyte and liver copper levels and serum ferroxidase (ceruloplasmin) activity in Mo (Br) (/y) mice, typifying the response to iron deprivation in many mammalian species.	Iron	28-32	ceruloplasmin	Mus musculus	132-145
27057839-6	2016	In the case of iron overload disorders (e.g., hereditary hemochromatosis and beta-thalassemia), hepatic hepcidin concentration is significantly reduced.Since hepcidin deregulation is responsible for iron disorder-associated diseases, the purpose of this review is to summarize the recent findings on therapeutics targeting hepcidin.Continuous efforts have been made to search for hepcidin mimics and chemical compounds that could be used to increase hepcidin level.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	158-166
23776592-10	2013	Conversely, upregulation of iron absorption was associated with increased enterocyte and liver copper levels and serum ferroxidase (ceruloplasmin) activity in Mo (Br) (/y) mice, typifying the response to iron deprivation in many mammalian species.	Iron	204-208	ceruloplasmin	Mus musculus	132-145
27057839-6	2016	In the case of iron overload disorders (e.g., hereditary hemochromatosis and beta-thalassemia), hepatic hepcidin concentration is significantly reduced.Since hepcidin deregulation is responsible for iron disorder-associated diseases, the purpose of this review is to summarize the recent findings on therapeutics targeting hepcidin.Continuous efforts have been made to search for hepcidin mimics and chemical compounds that could be used to increase hepcidin level.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	158-166
23776592-12	2013	In summary, Mo (Br) (/y) mice were able to adequately regulate iron absorption, but unlike in WT mice, concurrent increases in enterocyte and liver copper levels and serum ferroxidase activity may have contributed to maintenance of iron homeostasis.	Iron	232-236	ceruloplasmin	Mus musculus	172-183
27057839-6	2016	In the case of iron overload disorders (e.g., hereditary hemochromatosis and beta-thalassemia), hepatic hepcidin concentration is significantly reduced.Since hepcidin deregulation is responsible for iron disorder-associated diseases, the purpose of this review is to summarize the recent findings on therapeutics targeting hepcidin.Continuous efforts have been made to search for hepcidin mimics and chemical compounds that could be used to increase hepcidin level.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	158-166
27057839-9	2016	We also discussed the molecular mechanisms by which hepcidin level and iron metabolism are modulated.Elevating hepcidin concentration is an optimal strategy to ameliorate iron overload diseases, and also to relieve beta-thalassemia phenotypes by improving ineffective erythropoiesis.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	111-119
27057839-9	2016	We also discussed the molecular mechanisms by which hepcidin level and iron metabolism are modulated.Elevating hepcidin concentration is an optimal strategy to ameliorate iron overload diseases, and also to relieve beta-thalassemia phenotypes by improving ineffective erythropoiesis.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	111-119
23604471-0	2013	A high-throughput method for the quantification of iron saturation in lactoferrin preparations.	Iron	51-55	lactotransferrin	Bos taurus	70-81
25870938-2	2016	Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated tau depending on NBIA subtype.	Iron	0-4	microtubule associated protein tau	Homo sapiens	118-121
23604471-1	2013	Lactoferrin is considered as a part of the innate immune system that plays a crucial role in preventing bacterial growth, mostly via an iron sequestration mechanism.	Iron	136-140	lactotransferrin	Bos taurus	0-11
23604471-2	2013	Recent data show that bovine lactoferrin prevents late-onset sepsis in preterm very low birth weight neonates by serving as an iron chelator for some bacterial strains; thus, it is very important to control the iron saturation level during diet supplementation.	Iron	127-131	lactotransferrin	Bos taurus	29-40
23604471-2	2013	Recent data show that bovine lactoferrin prevents late-onset sepsis in preterm very low birth weight neonates by serving as an iron chelator for some bacterial strains; thus, it is very important to control the iron saturation level during diet supplementation.	Iron	211-215	lactotransferrin	Bos taurus	29-40
23604471-3	2013	An accurate estimation of lactoferrin iron saturation is essential not only because of its clinical applications but also for a wide range of biochemical experiments.	Iron	38-42	lactotransferrin	Bos taurus	26-37
23604471-4	2013	A comprehensive method for the quantification of iron saturation in lactoferrin preparations was developed to obtain a calibration curve enabling the determination of iron saturation levels relying exclusively on the defined ratio of absorbances at 280 and 466 nm (A(280/466)).	Iron	49-53	lactotransferrin	Bos taurus	68-79
23604471-6	2013	The ability to obtain samples of lactoferrin with determination of its iron content in a simple and fast way has been proven to be very useful.	Iron	71-75	lactotransferrin	Bos taurus	33-44
25870938-3	2016	Mutations in 10 genes have been associated with NBIA that include Ceruloplasmin (Cp) and ferritin light chain (FTL), both directly involved in iron homeostasis, as well as Pantothenate Kinase 2 (PANK2), Phospholipase A2 group 6 (PLA2G6), Fatty acid hydroxylase 2 (FA2H), Coenzyme A synthase (COASY), C19orf12, WDR45 and DCAF17 (C2orf37).	Iron	143-147	ceruloplasmin	Homo sapiens	66-79
25870938-3	2016	Mutations in 10 genes have been associated with NBIA that include Ceruloplasmin (Cp) and ferritin light chain (FTL), both directly involved in iron homeostasis, as well as Pantothenate Kinase 2 (PANK2), Phospholipase A2 group 6 (PLA2G6), Fatty acid hydroxylase 2 (FA2H), Coenzyme A synthase (COASY), C19orf12, WDR45 and DCAF17 (C2orf37).	Iron	143-147	ceruloplasmin	Homo sapiens	81-83
26842695-1	2016	Hepcidin regulates serum iron levels, and its dosage is used in differential diagnostic of iron-related pathologies.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
23541988-5	2013	RESULTS: This mode of iron uptake is a saturable, energy dependent pathway, utilizing raft as well as non-raft domains of the cell membrane and also involves the membrane protein CD87 (uPAR).	Iron	22-26	plasminogen activator, urokinase receptor	Homo sapiens	179-183
23541988-5	2013	RESULTS: This mode of iron uptake is a saturable, energy dependent pathway, utilizing raft as well as non-raft domains of the cell membrane and also involves the membrane protein CD87 (uPAR).	Iron	22-26	plasminogen activator, urokinase receptor	Homo sapiens	185-189
26842695-1	2016	Hepcidin regulates serum iron levels, and its dosage is used in differential diagnostic of iron-related pathologies.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
23411185-2	2013	Rice with high iron content in seed endosperm has been developed by insertion of soybean ferritin gene under the control of the endosperm specific glutelin promoter into the genome of indica rice line IR68144.	Iron	15-19	ferritin-1, chloroplastic	Glycine max	89-97
26842695-10	2016	Iron stimulated the release of hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	31-39
26842695-13	2016	The HEPMEN study showed fluctuations of iron-status variables during the menstrual cycle, which should be considered when using hepcidin measurements for diagnostic purposes in women of child-bearing potential.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	128-136
23729726-2	2013	This protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	96-104
26843153-11	2016	The withholding of iron from children with severe malaria is associated with lower ferritin and hepcidin at day 28 but not a lower hemoglobin concentration.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	96-104
23729726-8	2013	In contrast to the low/undetectable hepcidin levels observed in acquired iron deficiency, in patients with Matriptase-2 deficiency, serum hepcidin is inappropriately high for the low iron status and accounts for the absent/delayed response to oral iron treatment.	Iron	183-187	hepcidin antimicrobial peptide	Homo sapiens	138-146
23729726-10	2013	The current treatment of iron refractory iron deficiency anemia is based on parenteral iron administration; in the future, manipulation of the hepcidin pathway with the aim of suppressing it might become an alternative therapeutic approach.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	143-151
26912011-0	2016	Reduced iron parameters and cognitive processes in children and adolescents with DM1 compared to those with standard parameters.	Iron	8-12	immunoglobulin heavy diversity 1-7	Homo sapiens	81-84
24149803-10	2013	Additionally, an increased concentration of the iron homeostasis regulator hepcidin was found in blood samples (mean 71 ng ml(-1); range from 48 to 100 ng ml(-1)).	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	75-83
24149803-12	2013	Key PointsThe first research demonstrating low grade inflammation-induced iron deficiency to be associated with elevated blood hepcidin levels in young tennis athletes.Evaluation of immunological response after the complete tournament season in young male tennis players.Conclusion to introduce the assessment of hepcidin to monitor trainings as well as symptoms of overreaching more effectively.Research providing practical information for coaches that changes in diet and modifications in workloads applied in physical training could be more effective than iron supplementation in iron deficient athletes.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	127-135
27255060-8	2016	Once the ulcer became clean, a total contact cast was applied with a walking iron for ambulation.	Iron	77-81	calpastatin	Homo sapiens	45-49
23530061-0	2013	Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.	Iron	108-112	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	42-46
23530061-0	2013	Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.	Iron	108-112	Tis11p	Saccharomyces cerevisiae S288C	51-55
23530061-6	2013	By mutagenesis of the AREs within the CTH2 transcript, we demonstrate that a Cth2 negative-feedback loop is required for the efficient decline in Cth2 protein levels observed upon a rapid rise in Fe availability.	Iron	196-198	Tis11p	Saccharomyces cerevisiae S288C	38-42
26945394-1	2016	Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of iron homeostasis.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	10-18
23530061-6	2013	By mutagenesis of the AREs within the CTH2 transcript, we demonstrate that a Cth2 negative-feedback loop is required for the efficient decline in Cth2 protein levels observed upon a rapid rise in Fe availability.	Iron	196-198	Tis11p	Saccharomyces cerevisiae S288C	77-81
23530061-6	2013	By mutagenesis of the AREs within the CTH2 transcript, we demonstrate that a Cth2 negative-feedback loop is required for the efficient decline in Cth2 protein levels observed upon a rapid rise in Fe availability.	Iron	196-198	Tis11p	Saccharomyces cerevisiae S288C	146-150
23530061-7	2013	Importantly, Cth2 autoregulation is critical for the appropriate recovery of Fe-dependent processes and resumption of growth in response to a change from Fe deficiency to Fe supplementation.	Iron	77-79	Tis11p	Saccharomyces cerevisiae S288C	13-17
23530061-7	2013	Importantly, Cth2 autoregulation is critical for the appropriate recovery of Fe-dependent processes and resumption of growth in response to a change from Fe deficiency to Fe supplementation.	Iron	154-156	Tis11p	Saccharomyces cerevisiae S288C	13-17
26577249-9	2016	CONCLUSION: DFO induced an increase in LDLR expression by a posttranscriptional mechanism resulting in an enhancement of LDL uptake in HepG2 cells, suggesting increased LDLR activity as one of the underlying causes of the hypocholesterolemic effect of iron reduction.	Iron	252-256	low density lipoprotein receptor	Homo sapiens	39-43
23615448-0	2013	Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.	Iron	57-61	glutaredoxin 3	Homo sapiens	31-45
23615448-0	2013	Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.	Iron	57-61	glutaredoxin 3	Homo sapiens	47-52
23615448-4	2013	Here we demonstrate a crucial role of the vertebrate-specific monothiol multidomain Grx3 (PICOT) in cellular iron homeostasis.	Iron	109-113	glutaredoxin 3	Homo sapiens	84-88
23615448-4	2013	Here we demonstrate a crucial role of the vertebrate-specific monothiol multidomain Grx3 (PICOT) in cellular iron homeostasis.	Iron	109-113	glutaredoxin 3	Homo sapiens	90-95
23615448-5	2013	During zebrafish embryonic development, depletion of Grx3 severely impairs the maturation of hemoglobin, the major iron-consuming process.	Iron	115-119	glutaredoxin 3	Danio rerio	53-57
23615448-6	2013	Silencing of human Grx3 expression in HeLa cells decreases the activities of several cytosolic Fe/S proteins, for example, iron-regulatory protein 1, a major component of posttranscriptional iron regulation.	Iron	123-127	glutaredoxin 3	Homo sapiens	19-23
23615448-7	2013	As a consequence, Grx3-depleted cells show decreased levels of ferritin and increased levels of transferrin receptor, features characteristic of cellular iron starvation.	Iron	154-158	glutaredoxin 3	Homo sapiens	18-22
23615448-8	2013	Apparently, Grx3-deficient cells are unable to efficiently use iron, despite unimpaired cellular iron uptake.	Iron	63-67	glutaredoxin 3	Homo sapiens	12-16
23335088-1	2013	BACKGROUND: Growth differentiation factor 15 (GDF15), a divergent TGFbeta superfamily, has recently been implicated in the modulation of iron homeostasis, acting as an upstream negative regulator of hepcidin, the key iron regulatory hormone produced primarily by hepatocytes.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	199-207
23335088-1	2013	BACKGROUND: Growth differentiation factor 15 (GDF15), a divergent TGFbeta superfamily, has recently been implicated in the modulation of iron homeostasis, acting as an upstream negative regulator of hepcidin, the key iron regulatory hormone produced primarily by hepatocytes.	Iron	217-221	hepcidin antimicrobial peptide	Homo sapiens	199-207
23412555-0	2013	Ligand discrimination of myoglobin in solution: an iron L-edge X-ray absorption study of the active centre.	Iron	51-55	myoglobin	Homo sapiens	25-34
23412555-1	2013	Iron L-edge X-ray absorption spectra of the active centre of myoglobin in the met-form, in the reduced form and upon ligation to O2, CO, NO and CN are presented.	Iron	0-4	myoglobin	Homo sapiens	61-70
23675470-1	2013	The liver, as the major organ for iron storage and production of hepcidin, plays pivotal roles in maintaining mammalian iron homeostasis.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	65-73
23062413-1	2013	OBJECTIVE: Hepcidin regulates iron absorption and recycling and is central to host defense, protection from reactive iron species, and a biomarker of iron-related pathophysiology.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	11-19
23062413-1	2013	OBJECTIVE: Hepcidin regulates iron absorption and recycling and is central to host defense, protection from reactive iron species, and a biomarker of iron-related pathophysiology.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	11-19
23062413-1	2013	OBJECTIVE: Hepcidin regulates iron absorption and recycling and is central to host defense, protection from reactive iron species, and a biomarker of iron-related pathophysiology.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	11-19
23651750-4	2013	Their parents were both HJV heterozygous with normal iron status.	Iron	53-57	hemojuvelin BMP co-receptor	Homo sapiens	24-27
23438894-1	2013	Systemic iron homeostasis is finely regulated by the liver through synthesis of the peptide hormone hepcidin (HAMP), which plays an important role in duodenal iron absorption and macrophage iron release.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	100-108
23438894-1	2013	Systemic iron homeostasis is finely regulated by the liver through synthesis of the peptide hormone hepcidin (HAMP), which plays an important role in duodenal iron absorption and macrophage iron release.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	110-114
23438894-1	2013	Systemic iron homeostasis is finely regulated by the liver through synthesis of the peptide hormone hepcidin (HAMP), which plays an important role in duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	100-108
23438894-1	2013	Systemic iron homeostasis is finely regulated by the liver through synthesis of the peptide hormone hepcidin (HAMP), which plays an important role in duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	110-114
23438894-1	2013	Systemic iron homeostasis is finely regulated by the liver through synthesis of the peptide hormone hepcidin (HAMP), which plays an important role in duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	100-108
23438894-1	2013	Systemic iron homeostasis is finely regulated by the liver through synthesis of the peptide hormone hepcidin (HAMP), which plays an important role in duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	110-114
23438894-6	2013	Consistently, overexpression of PGC-1alpha in HepG2 or HuH7 cells also suppresses HAMP expression and reduces iron accumulation.	Iron	110-114	PPARG coactivator 1 alpha	Sus scrofa	32-42
23403148-4	2013	One of the key molecules implicated in sPE pathogenesis is heme oxygenase-1 (HO-1), a rate-limiting enzyme that breaks down heme into carbon monoxide (CO), biliverdin and free iron.	Iron	176-180	heme oxygenase 1	Homo sapiens	59-75
23403148-4	2013	One of the key molecules implicated in sPE pathogenesis is heme oxygenase-1 (HO-1), a rate-limiting enzyme that breaks down heme into carbon monoxide (CO), biliverdin and free iron.	Iron	176-180	heme oxygenase 1	Homo sapiens	77-81
23700940-2	2013	The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD).	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	63-71
23523353-1	2013	Mammalian iron metabolism is regulated systemically by the hormone hepcidin and cellularly by iron regulatory proteins (IRPs) that orchestrate a posttranscriptional regulatory network.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	67-75
23531037-1	2013	BACKGROUND: Hepcidin is a central regulator of iron metabolism.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	12-20
23349391-3	2013	This is a consequence of hepcidin-induced internalization and subsequent degradation of ferroportin, the hepcidin receptor and only known iron-export protein.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	25-33
23293962-7	2013	Taken together, the results of the present study have characterized HAI-2 as an inhibitor of matriptase-2 that modulates the synthesis of hepcidin and provides new insights into the regulatory mechanism of iron homoeostasis, with clinical importance for a treatment of iron overload diseases.	Iron	206-210	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	68-73
23416069-0	2013	Snx3 regulates recycling of the transferrin receptor and iron assimilation.	Iron	57-61	sorting nexin 3	Homo sapiens	0-4
23416069-3	2013	Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors.	Iron	148-152	sorting nexin 3	Homo sapiens	20-35
23416069-3	2013	Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors.	Iron	148-152	sorting nexin 3	Homo sapiens	37-41
23416069-5	2013	Silencing of Snx3 results in anemia and hemoglobin defects in vertebrates due to impaired transferrin (Tf)-mediated iron uptake and its accumulation in early endosomes.	Iron	116-120	sorting nexin 3	Homo sapiens	13-17
23416069-8	2013	Our findings uncover a role of Snx3 in regulating Tfrc recycling, iron homeostasis, and erythropoiesis.	Iron	66-70	sorting nexin 3	Homo sapiens	31-35
23416069-9	2013	Thus, the identification of Snx3 provides a genetic tool for exploring erythropoiesis and disorders of iron metabolism.	Iron	103-107	sorting nexin 3	Homo sapiens	28-32
23232066-1	2013	BACKGROUND: The iron-regulating hormone hepcidin is a promising biomarker in the diagnosis of iron disorders.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	40-48
23232066-4	2013	We aimed to assess the effect of dietary iron on hepcidin concentrations during the day.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	49-57
23232066-7	2013	A linear mixed model for repeated data was used to analyze the effect of iron intake on TS and hepcidin concentrations.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	95-103
23232066-9	2013	During the day of an iron-deficient diet the mean TS was similar both in men and in women, whereas hepcidin increased.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	99-107
23232066-12	2013	These findings will be useful for optimizing sampling protocols and will facilitate the interpretation of hepcidin as an iron biomarker.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	106-114
23178646-2	2013	Hepcidin, the major regulatory protein for iron metabolism, may play a causative role.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
22983584-3	2013	In this study, we analyzed iron-related parameters in mice deficient for GDF15 under steady-state conditions and in response to increased erythropoietic activity induced by blood loss.	Iron	27-31	growth differentiation factor 15	Mus musculus	73-78
23412550-1	2013	We have previously shown that methionine-heme iron coordination is perturbed in domain-swapped dimeric horse cytochrome c.	Iron	46-50	cytochrome c, somatic	Equus caballus	109-121
23412550-7	2013	The low nu                 (Fe-CN) frequency suggests weaker binding of the cyanide ion to dimeric cytochrome c compared with other heme proteins possessing a distal heme cavity.	Iron	28-30	cytochrome c, somatic	Equus caballus	99-111
23412550-9	2013	The results show that diatomic ligands may bind to the heme iron of dimeric cytochrome c and affect its stability.	Iron	60-64	cytochrome c, somatic	Equus caballus	76-88
23524455-7	2013	CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG.	Iron	99-101	ceruloplasmin	Homo sapiens	0-2
23673847-5	2013	PC1 had a high loading for Mg, Cu, Zn, Al, and Fe; PC2 was related to N, K, and Mn; and PC3 and PC4 mainly represented P and Ca.	Iron	47-49	proprotein convertase subtilisin/kexin type 1	Homo sapiens	0-3
27236128-4	2016	Together with impaired renal production of erythropoietin, hepcidin-mediated iron restriction contributes to anemia of chronic kidney disease.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	59-67
26914026-0	2016	Correction: N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion.	Iron	138-142	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	98-103
22722675-8	2013	CONCLUSION: Maternal obesity is associated with impaired maternal-fetal iron transfer, potentially through hepcidin upregulation.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	107-115
26878799-0	2016	Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	15-19
26894030-1	2013	Hepcidin, produced by the liver, is the master regulator of iron balance.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
26894030-2	2013	Serum hepcidin is increased by high iron stores, blocks intestinal iron absorption, and impairs storage iron release.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	6-14
26894030-2	2013	Serum hepcidin is increased by high iron stores, blocks intestinal iron absorption, and impairs storage iron release.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	6-14
26878799-0	2016	Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity.	Iron	0-4	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	60-64
26894030-2	2013	Serum hepcidin is increased by high iron stores, blocks intestinal iron absorption, and impairs storage iron release.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	6-14
26894030-3	2013	Conversely, iron deficiency lowers hepcidin levels and enhances intestinal iron absorption and the release of storage iron.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	35-43
26878799-0	2016	Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity.	Iron	101-105	solute carrier family 11 member 2	Homo sapiens	15-19
26743084-2	2016	Although cellular Fe import is well understood, its export is thought to be limited to transmembrane extrusion through ferroportin (also known as Slc40a1), the only known mammalian Fe exporter.	Iron	18-20	solute carrier family 40 member 1	Homo sapiens	146-153
23433094-8	2013	In patients without acute inflammation and overt iron deficiency (C reactive protein &lt;1 mg/dl and ferritin &gt;30 ng/ml; n = 86), hepcidin was associated with lower mean corpuscular volume (p = 0.002), suggesting that it contributed to iron-restricted erythropoiesis.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	133-141
26792471-9	2016	The proportion with IDA and hepcidin concentration &lt;= 20.0 ng/ml (predictive of responsiveness to oral iron supplementation) was also very low (median &lt;3%, range 0-15.1).	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	28-36
23314535-1	2013	Hepcidin is an iron regulatory protein mainly synthesized by the liver.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
23314535-2	2013	Hepatocyte production of hepcidin is responsible for serum hepcidin, is responsive to body iron stores, and is critical for maintaining iron homeostasis.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	25-33
23314535-2	2013	Hepatocyte production of hepcidin is responsible for serum hepcidin, is responsive to body iron stores, and is critical for maintaining iron homeostasis.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	25-33
26596411-2	2016	Physiologically, the liver synthesizes transferrin, in charge of blood iron transport; ceruloplasmin, acting through its ferroxidase activity; and hepcidin, the master regulator of systemic iron.	Iron	190-194	hepcidin antimicrobial peptide	Homo sapiens	147-155
26596411-5	2016	The liver is strongly involved when iron excess is related either to hepcidin deficiency, as in HFE, hemojuvelin, hepcidin, and transferrin receptor 2 related haemochromatosis, or to hepcidin resistance, as in type B ferroportin disease.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	69-77
26596411-5	2016	The liver is strongly involved when iron excess is related either to hepcidin deficiency, as in HFE, hemojuvelin, hepcidin, and transferrin receptor 2 related haemochromatosis, or to hepcidin resistance, as in type B ferroportin disease.	Iron	36-40	hemojuvelin BMP co-receptor	Homo sapiens	101-112
26935626-6	2016	Functional loss of matriptase-2 due to homozygous mutations results in an increase in the expression of hepcidin, which is the key regulator of systemic iron homeostasis.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	104-112
26935626-7	2016	The serum hepcidin increase in turn leads to a decrease in iron supply from the intestine and macrophages to erythropoietic cells.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	10-18
26394360-0	2016	Effects of oral supplementation of iron on hepcidin blood concentrations among non-anaemic female blood donors: a randomized controlled trial.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	43-51
26394360-1	2016	BACKGROUND AND OBJECTIVES: Hepcidin is the main hormone that regulates iron balance.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	27-35
26394360-8	2016	RESULTS: Iron supplementation had a significant effect on plasma hepcidin compared to the placebo arm at 4 weeks [+0 29 nm [95% CI: 0 18 to 0 40]).	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	65-73
26394360-12	2016	CONCLUSIONS: This study shows that a 4-week oral treatment of iron increased hepcidin blood concentrations in female blood donors with an initial ferritin concentration of less than 30 ng/ml.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	77-85
26394360-13	2016	Apparently, hepcidin cannot serve as a predictor of response to iron treatment but might serve as a marker of the iron repletion needed for erythropoiesis.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	12-20
26695452-2	2016	Concentrations of 5-10 mol % of each of Fe and Co have been doped for the B-site of BCS by citric acid autocombustion method.	Iron	40-42	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	84-87
26695452-7	2016	TG has also proved that the incorporation of Fe and Co in BCS did not improve the chemical stability in CO2 at elevated temperature.	Iron	45-47	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	58-61
26652036-1	2016	The two isoforms of human heme oxygenase (HO1 and HO2) catalyze oxidative degradation of heme to biliverdin, Fe, and CO.	Iron	109-111	heme oxygenase 1	Homo sapiens	42-45
26748339-1	2016	In mycobacteria, various type VII secretion systems corresponding to different ESX (ESAT-6 secretory) types, are contributing to pathogenicity, iron acquisition, and/or conjugation.	Iron	144-148	E74 like ETS transcription factor 3	Homo sapiens	79-82
26728034-1	2016	BACKGROUND: Mitochondria play essential biological functions including the synthesis and trafficking of porphyrins and iron/sulfur clusters (ISC), processes that in mammals involve the mitochondrial ATP-Binding Cassette (ABC) transporters ABCB6 and ABCB7, respectively.	Iron	119-123	ATP binding cassette subfamily B member 7	Homo sapiens	249-254
27101282-9	2016	The administration of excessive amounts of iron may modify iron localization by an increase in the hepcidin concentration.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	99-107
27101282-9	2016	The administration of excessive amounts of iron may modify iron localization by an increase in the hepcidin concentration.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	99-107
26981017-1	2016	Hepcidin is a small peptide with a critical role in cellular iron homeostasis, as it regulates utilization of stored iron and antimicrobial defense in inflammation (bacterial and fungal).	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
26981017-1	2016	Hepcidin is a small peptide with a critical role in cellular iron homeostasis, as it regulates utilization of stored iron and antimicrobial defense in inflammation (bacterial and fungal).	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	0-8
26981017-3	2016	Hepcidin regulation is delicately tuned by two inflammatory pathways activated by interleukin-6 (IL-6) and bone morphogenic proteins (BMPs) and iron regulated pathway sensitive to circulating transferin-iron (TR-Fe) complex.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	0-8
26981017-3	2016	Hepcidin regulation is delicately tuned by two inflammatory pathways activated by interleukin-6 (IL-6) and bone morphogenic proteins (BMPs) and iron regulated pathway sensitive to circulating transferin-iron (TR-Fe) complex.	Iron	203-207	hepcidin antimicrobial peptide	Homo sapiens	0-8
26981017-4	2016	BMP-mediated pathway and TR-Fe sensitive pathway seem to be connected by hemojuveline, a BMP co-factor that interacts with transferine receptor 2 (TRF2) in cases of high TR-Fe circulatory concentration.	Iron	28-30	bone morphogenetic protein 1	Homo sapiens	89-92
26124055-1	2016	BACKGROUND: The expression of the key iron regulatory hormone hepcidin is regulated by iron availability, inflammation, hormones, hypoxia, and anaemia.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	62-70
26124055-1	2016	BACKGROUND: The expression of the key iron regulatory hormone hepcidin is regulated by iron availability, inflammation, hormones, hypoxia, and anaemia.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	62-70
26124055-9	2016	Most hepcidin correlates were in line with hepcidin as an indicator of iron stores.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	5-13
26124055-9	2016	Most hepcidin correlates were in line with hepcidin as an indicator of iron stores.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	43-51
27642607-2	2016	Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	89-97
26212583-1	2016	OBJECTIVE: To investigate hepcidin during pregnancy, delivery and postpartum in women with sufficient iron supplementation.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	26-34
26212583-5	2016	CONCLUSION: During pregnancy, in women with sufficient iron supplementation, hepcidin is low and does not reflect iron status.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	77-85
26774668-10	2016	These include a single base deletion mutation in the ferritin heavy chain gene (FTH1) resulting in a frame shift and protein truncation in TK6 that impairs iron metabolism.	Iron	156-160	ferritin heavy chain 1	Homo sapiens	53-73
26774668-10	2016	These include a single base deletion mutation in the ferritin heavy chain gene (FTH1) resulting in a frame shift and protein truncation in TK6 that impairs iron metabolism.	Iron	156-160	ferritin heavy chain 1	Homo sapiens	80-84
26556796-0	2016	ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses.	Iron	70-74	C2H2-type zinc finger family protein	Arabidopsis thaliana	39-44
23178444-2	2013	The expression of FPN is positively induced by cellular iron and is suppressed by liver hepcidin in response to either increased systemic iron or inflammatory stimuli.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	88-96
23178444-3	2013	Hepcidin binds to cell surface FPN inducing FPN internalization followed by lysosomal degradation of the protein and consequently iron efflux from macrophages is blocked and there is suboptimal iron absorption by duodenal enterocytes.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	0-8
23178444-3	2013	Hepcidin binds to cell surface FPN inducing FPN internalization followed by lysosomal degradation of the protein and consequently iron efflux from macrophages is blocked and there is suboptimal iron absorption by duodenal enterocytes.	Iron	194-198	hepcidin antimicrobial peptide	Homo sapiens	0-8
23178444-7	2013	Resistance to hepcidin promotes iron egress from cells and this inhibits growth of intracellular pathogens.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	14-22
26556796-0	2016	ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses.	Iron	129-133	C2H2-type zinc finger family protein	Arabidopsis thaliana	39-44
26556796-7	2016	In the absence of ZAT12, FIT expression was upregulated, suggesting a negative effect of ZAT12 on Fe uptake.	Iron	98-100	C2H2-type zinc finger family protein	Arabidopsis thaliana	89-94
26556796-8	2016	Consistently, zat12 loss-of-function mutants had higher Fe content than the wild type at sufficient Fe.	Iron	56-58	C2H2-type zinc finger family protein	Arabidopsis thaliana	14-19
23012398-0	2013	Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	98-102
26556796-8	2016	Consistently, zat12 loss-of-function mutants had higher Fe content than the wild type at sufficient Fe.	Iron	100-102	C2H2-type zinc finger family protein	Arabidopsis thaliana	14-19
23012398-0	2013	Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	107-114
26556796-11	2016	We propose that oxidative stress-induced ZAT12 functions as a negative regulator of Fe acquisition.	Iron	84-86	C2H2-type zinc finger family protein	Arabidopsis thaliana	41-46
27085736-5	2016	Targeting iron trafficking via ferritin, ferroportin, or hepcidin may offer new insights.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	57-65
22274938-4	2013	Interestingly, hLF transgenic tobacco showed higher level of transcript expression for genes related to iron content regulation like iron transporter and metal transporter.	Iron	104-108	HLF transcription factor, PAR bZIP family member	Homo sapiens	15-18
28124024-0	2016	Iron Supplementation Alters Heme and Heme Oxygenase 1 (HO-1) Levels In Pregnant Women in Ghana.	Iron	0-4	heme oxygenase 1	Homo sapiens	37-53
23379486-0	2013	Hepcidin is a potential regulator of iron status in chronic kidney disease.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
23379486-2	2013	In addition to hepcidin"s antimicrobial properties, it is the main regulator of iron metabolism and controls both the amount of dietary iron absorbed in the duodenum and the iron release by reticuloendothelial cells.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	15-23
23379486-2	2013	In addition to hepcidin"s antimicrobial properties, it is the main regulator of iron metabolism and controls both the amount of dietary iron absorbed in the duodenum and the iron release by reticuloendothelial cells.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	15-23
23379486-2	2013	In addition to hepcidin"s antimicrobial properties, it is the main regulator of iron metabolism and controls both the amount of dietary iron absorbed in the duodenum and the iron release by reticuloendothelial cells.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	15-23
23379486-3	2013	Hepcidin expression is upregulated by a variety of stimuli, including inflammation and iron overload, and downregulated by anemia, hypoxia, and iron deficiency.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
23379486-5	2013	Elevated serum hepcidin levels contribute to the dysregulation of iron homeostasis in CKD patients.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	15-23
23379486-6	2013	Although parenteral iron supplementation can bypass some of the iron-blocking effects of hepcidin in CKD patients with anemia, and free iron and iron stores increase as a result, the anemia is only partially corrected, and the ESA dose requirements remain significantly higher than needed for physiological replacement.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	89-97
23379486-6	2013	Although parenteral iron supplementation can bypass some of the iron-blocking effects of hepcidin in CKD patients with anemia, and free iron and iron stores increase as a result, the anemia is only partially corrected, and the ESA dose requirements remain significantly higher than needed for physiological replacement.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	89-97
23379486-6	2013	Although parenteral iron supplementation can bypass some of the iron-blocking effects of hepcidin in CKD patients with anemia, and free iron and iron stores increase as a result, the anemia is only partially corrected, and the ESA dose requirements remain significantly higher than needed for physiological replacement.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	89-97
23379486-7	2013	Treatment with agents that lower serum hepcidin levels or inhibit its actions may be an effective strategy for restoring normal iron homeostasis and improving anemia in CKD patients.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	39-47
23214721-6	2013	This is the first structural and functional model of relevance to iron-containing acireductone dioxygenase (Fe-ARD"), an enzyme in the methionine salvage pathway that catalyzes the regiospecific oxidation of 1,2-dihydroxy-3-oxo-(S)-methylthiopentene to form 2-oxo-4-methylthiobutyrate.	Iron	66-70	acireductone dioxygenase 1	Homo sapiens	108-115
28124024-0	2016	Iron Supplementation Alters Heme and Heme Oxygenase 1 (HO-1) Levels In Pregnant Women in Ghana.	Iron	0-4	heme oxygenase 1	Homo sapiens	55-59
28124024-4	2016	We hypothesized that pregnant women with malaria who took iron supplements will have higher levels of Heme/HO-1 than those who did not take iron supplements.	Iron	58-62	heme oxygenase 1	Homo sapiens	107-111
26567217-2	2015	In this work, we show that, in Saccharomyces cerevisiae, defects at different stages of the mitochondrial Fe-S cluster assembly machinery (ISC) result in increased spontaneous mutation rate and hyper-recombination, accompanied by an increment in Rad52-associated DNA repair foci and a higher phosphorylated state of gammaH2A histone, altogether supporting the presence of constitutive DNA lesions.	Iron	106-108	recombinase RAD52	Saccharomyces cerevisiae S288C	246-251
22746342-1	2013	AIMS: Mitochondrial ferritin (MtFt), which was recently discovered, plays an important role in preventing neuronal damage in 6-hydroxydopamine-induced Parkinsonism by maintaining mitochondrial iron homeostasis.	Iron	193-197	ferritin mitochondrial	Homo sapiens	6-28
22746342-1	2013	AIMS: Mitochondrial ferritin (MtFt), which was recently discovered, plays an important role in preventing neuronal damage in 6-hydroxydopamine-induced Parkinsonism by maintaining mitochondrial iron homeostasis.	Iron	193-197	ferritin mitochondrial	Homo sapiens	30-34
22746342-4	2013	RESULTS: We report that knockdown of MtFt expression significantly enhanced Abeta(25-35)-induced neurotoxicity as shown by dysregulation of iron homeostasis, enhanced oxidative stress, and increased cell apoptosis.	Iron	140-144	ferritin mitochondrial	Homo sapiens	37-41
26423448-1	2015	The phenomenon that heme oxygenase-1 (HO-1) protects cell from injury yet its enzymatic product, iron, may facilitate generation of free radical has been long puzzling.	Iron	97-101	heme oxygenase 1	Homo sapiens	20-36
23147497-9	2013	RESULTS: Treatment of iron overloaded mice with either low or high doses of Danshen not only significantly attenuated the hepatic dysfunction (ALT/AST levels), decreased the content of MDA and increased the activities of GSH-Px and SOD, it also suppressed apoptosis in hepatocytes.	Iron	22-26	glutamic pyruvic transaminase, soluble	Mus musculus	143-146
23147497-9	2013	RESULTS: Treatment of iron overloaded mice with either low or high doses of Danshen not only significantly attenuated the hepatic dysfunction (ALT/AST levels), decreased the content of MDA and increased the activities of GSH-Px and SOD, it also suppressed apoptosis in hepatocytes.	Iron	22-26	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	147-150
26423448-1	2015	The phenomenon that heme oxygenase-1 (HO-1) protects cell from injury yet its enzymatic product, iron, may facilitate generation of free radical has been long puzzling.	Iron	97-101	heme oxygenase 1	Homo sapiens	38-42
26423448-6	2015	RNA interference of HO-1 makes the cell more susceptible to hydrogen peroxide, which can be rescued by forced expression of wild-type FHC but not mutants that lose the capacity of iron storage and ferroxidase activity.	Iron	180-184	heme oxygenase 1	Homo sapiens	20-24
26423448-9	2015	Our results support the role of FHC in neutralizing the iron toxicity as well as mediating the protective effect of HO-1 in response to oxidative stress.	Iron	56-60	ferritin heavy chain 1	Homo sapiens	32-35
23303302-5	2013	FE enhanced apoptosis in cancer cells that responded to treatment with three chemotherapeutic drugs with downregulation of the anti-apoptotic proteins Bcl-xL and Mcl-1.	Iron	0-2	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	162-167
26460251-1	2015	Levels of hepcidin, a key modulator of iron metabolism, are influenced by erythropoiesis, iron, and inflammation, all of which may be increased in patients with sickle cell disease (SCD).	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	10-18
23147477-10	2013	CONCLUSION: In stable heart failure patients with anemia, hepcidin levels may be more importantly regulated by patients" iron stores than by inflammation.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	58-66
26460251-1	2015	Levels of hepcidin, a key modulator of iron metabolism, are influenced by erythropoiesis, iron, and inflammation, all of which may be increased in patients with sickle cell disease (SCD).	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	10-18
26460251-10	2015	In conclusion, erythropoietic drive, iron status, and inflammation all contribute to variation in hepcidin level.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	98-106
23108765-0	2013	Iron autointoxication in a 16-year-old girl: a protective role for hepcidin?	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	67-75
26164540-1	2015	OBJECTIVES: Hepcidin is the main regulator of systemic iron homeostasis and its expression is modulated by iron status, hypoxia, erythroid factors and inflammation.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	12-20
23357152-19	2013	Newer laboratory parameters (Reticulocyte-He, low/medium/high fluorescence reticulocytes (LFR/MFR/HFR)) assessing iron status may be helpful in early detection of ID and in monitoring iron replacement therapy.	Iron	114-118	intelectin 1	Homo sapiens	90-93
26164540-1	2015	OBJECTIVES: Hepcidin is the main regulator of systemic iron homeostasis and its expression is modulated by iron status, hypoxia, erythroid factors and inflammation.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	12-20
22989377-5	2013	However, HO-1-overexpressing cells contain only ~25% as much "loose" (probably redox active) iron.	Iron	93-97	heme oxygenase 1	Homo sapiens	9-13
22989377-9	2013	We conclude that, at least in many cases, the cytoprotective effects of HO-1 induction or forced overexpression may derive from elevated expression of ferritin and consequent reduction of redox active "loose" iron.	Iron	209-213	heme oxygenase 1	Homo sapiens	72-76
26164540-2	2015	The aim of our study was to examine a relationship between level of hepcidin and iron status, erythropoietic activity, hypoxia and inflammation in exacerbations and stable COPD patients.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	68-76
26404482-2	2015	The mechanisms of the oxidative C H bond cleavage of toluene derivatives, sulfoxidation of thioanisole derivatives, and epoxidation of styrene derivatives by mononuclear nonheme iron(IV)-oxo complexes in the presence of triflic acid (HOTf) and Sc(OTf)3 have been unified as rate-determining electron transfer coupled with binding of Lewis acids (HOTf and Sc(OTf)3 ) by iron(III)-oxo complexes.	Iron	178-182	POU class 5 homeobox 1	Homo sapiens	244-252
24112172-5	2013	Western blotting analysis showed that the proliferating cell nuclear antigen (PCNA) expression following treatment with soluble divalent iron and trivalent iron at 100, 300 and 500 micromol/L was reduced compared to the control.	Iron	137-141	proliferating cell nuclear antigen	Homo sapiens	42-76
24112172-5	2013	Western blotting analysis showed that the proliferating cell nuclear antigen (PCNA) expression following treatment with soluble divalent iron and trivalent iron at 100, 300 and 500 micromol/L was reduced compared to the control.	Iron	137-141	proliferating cell nuclear antigen	Homo sapiens	78-82
24112172-5	2013	Western blotting analysis showed that the proliferating cell nuclear antigen (PCNA) expression following treatment with soluble divalent iron and trivalent iron at 100, 300 and 500 micromol/L was reduced compared to the control.	Iron	156-160	proliferating cell nuclear antigen	Homo sapiens	42-76
24112172-5	2013	Western blotting analysis showed that the proliferating cell nuclear antigen (PCNA) expression following treatment with soluble divalent iron and trivalent iron at 100, 300 and 500 micromol/L was reduced compared to the control.	Iron	156-160	proliferating cell nuclear antigen	Homo sapiens	78-82
24112172-6	2013	The PCNA expression decreased with increasing iron concentration and to a greater extent with the trivalent iron than with the divalent iron treatment group.	Iron	46-50	proliferating cell nuclear antigen	Homo sapiens	4-8
26404482-2	2015	The mechanisms of the oxidative C H bond cleavage of toluene derivatives, sulfoxidation of thioanisole derivatives, and epoxidation of styrene derivatives by mononuclear nonheme iron(IV)-oxo complexes in the presence of triflic acid (HOTf) and Sc(OTf)3 have been unified as rate-determining electron transfer coupled with binding of Lewis acids (HOTf and Sc(OTf)3 ) by iron(III)-oxo complexes.	Iron	178-182	POU class 5 homeobox 1	Homo sapiens	355-363
24112172-6	2013	The PCNA expression decreased with increasing iron concentration and to a greater extent with the trivalent iron than with the divalent iron treatment group.	Iron	108-112	proliferating cell nuclear antigen	Homo sapiens	4-8
24112172-6	2013	The PCNA expression decreased with increasing iron concentration and to a greater extent with the trivalent iron than with the divalent iron treatment group.	Iron	108-112	proliferating cell nuclear antigen	Homo sapiens	4-8
26475491-3	2015	In addition, the relationship between hepcidin (Hpc) - hormone regulating iron metabolism, and inflammation was studied.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	38-46
24112172-8	2013	CONCLUSION: The soluble divalent iron and, to a greater degree trivalent iron, inhibited HASMC proliferation in a dosedependent manner, which may be attributed to reduction of PCNA expression and increase of p53 expression.	Iron	33-37	proliferating cell nuclear antigen	Homo sapiens	176-180
24112172-8	2013	CONCLUSION: The soluble divalent iron and, to a greater degree trivalent iron, inhibited HASMC proliferation in a dosedependent manner, which may be attributed to reduction of PCNA expression and increase of p53 expression.	Iron	73-77	proliferating cell nuclear antigen	Homo sapiens	176-180
23092328-6	2013	HO-1 is a heme-degrading enzyme generating carbon monoxide, iron, and biliverdin/bilirubin, while BCRP is a heme efflux transporter.	Iron	60-64	heme oxygenase 1	Homo sapiens	0-4
26475491-3	2015	In addition, the relationship between hepcidin (Hpc) - hormone regulating iron metabolism, and inflammation was studied.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	48-51
26303407-0	2015	Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.	Iron	25-29	ceruloplasmin	Homo sapiens	0-2
23455037-6	2013	Here, we propose that Cullin-3 acts together with BTBD9 to limit the accumulation of iron regulatory proteins in conditions of iron deficiency.	Iron	85-89	Cullin 3	Drosophila melanogaster	22-30
26303407-2	2015	Patients with mutations in the cellular iron-exporting ferroxidase ceruloplasmin (Cp) have brain iron accumulation causing neurodegeneration.	Iron	40-44	ceruloplasmin	Homo sapiens	82-84
23455037-6	2013	Here, we propose that Cullin-3 acts together with BTBD9 to limit the accumulation of iron regulatory proteins in conditions of iron deficiency.	Iron	85-89	BTB (POZ) domain containing 9	Drosophila melanogaster	50-55
23455037-7	2013	Our model is consistent with clinical observations implicating iron homeostasis in the pathophysiology of RLS and predicts that lack of BTBD9 leads to misregulation of cellular iron storage, inactivating the critical biosynthetic enzyme Tyrosine Hydroxylase in dopaminergic neurons, with consequent phenotypic effects on sleep.	Iron	177-181	BTB (POZ) domain containing 9	Drosophila melanogaster	136-141
26303407-2	2015	Patients with mutations in the cellular iron-exporting ferroxidase ceruloplasmin (Cp) have brain iron accumulation causing neurodegeneration.	Iron	97-101	ceruloplasmin	Homo sapiens	82-84
26303407-12	2015	Below: In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels.	Iron	45-49	ceruloplasmin	Homo sapiens	32-34
26303407-12	2015	Below: In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels.	Iron	94-98	ceruloplasmin	Homo sapiens	32-34
26579185-8	2015	Finally, in mpk3, mpk6, and acs2 mutants under conditions of Fe deficiency, induction of transcript expression of the Fe-deficiency response genes FRO2, IRT1, and FIT is partially compromised.	Iron	61-63	1-amino-cyclopropane-1-carboxylate synthase 2	Arabidopsis thaliana	28-32
23817203-2	2013	Hepcidin is the body"s main regulator of systemic iron (Fe) and has been reported to be elevated in obese patients.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
23817203-2	2013	Hepcidin is the body"s main regulator of systemic iron (Fe) and has been reported to be elevated in obese patients.	Iron	56-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
24319154-6	2013	Hepcidin excess resulting from genetic inactivation of a hepcidin inhibitor, the transmembrane protease serine 6 (TMPRSS6) leads to a form of iron deficiency refractory to oral iron.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	0-8
24319154-6	2013	Hepcidin excess resulting from genetic inactivation of a hepcidin inhibitor, the transmembrane protease serine 6 (TMPRSS6) leads to a form of iron deficiency refractory to oral iron.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	57-65
24319154-7	2013	Increased hepcidin explains the iron sequestration and iron-restricted erythropoiesis of anemia associated with chronic inflammatory diseases.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	10-18
26579185-9	2015	Taken together, our results suggest that the MPK3/MPK6 and ACS2 are part of the Fe starvation-induced ethylene production signaling pathway.	Iron	80-82	1-amino-cyclopropane-1-carboxylate synthase 2	Arabidopsis thaliana	59-63
24319154-7	2013	Increased hepcidin explains the iron sequestration and iron-restricted erythropoiesis of anemia associated with chronic inflammatory diseases.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	10-18
26310624-0	2015	Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	9-17
24319154-9	2013	Hepcidin manipulation to restrict iron is a successful strategy to improve erythropoiesis in thalassemia, as shown clearly in preclinical studies targeting TMPRSS6; attempts to control anemia of chronic diseases by antagonizing the hepcidin effect are ongoing.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
24159420-2	2013	Metal ions like Cu, Fe and Zn are known to associate with the amyloid beta (A beta ) at high concentration and interaction of these ions with soluble and aggregated forms of A beta peptide help in development of AD.	Iron	20-22	beta amyloid protein precursor-like	Drosophila melanogaster	70-82
24159420-2	2013	Metal ions like Cu, Fe and Zn are known to associate with the amyloid beta (A beta ) at high concentration and interaction of these ions with soluble and aggregated forms of A beta peptide help in development of AD.	Iron	20-22	beta amyloid protein precursor-like	Drosophila melanogaster	76-82
26310624-3	2015	The aim of the present study was to define the genetics of this correlation and the effect of alpha-1-antitrypsin (A1AT) on the expression of the iron hormone hepcidin.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	159-167
25479470-2	2015	Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin control iron metabolism and are upregulated during renal stress.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	54-62
23390917-8	2013	Virulence genes that are involved in the intestinal phase of infection are located in SPI-1 and SPI-2 and the remaining SPIs are required for intracellular survival, fimbrial expression, magnesium and iron uptake, multiple antibiotic resistance and the development of systemic infections.	Iron	201-205	Spi-1 proto-oncogene	Homo sapiens	86-91
23262393-4	2013	High-dose iron treatment markedly increased the levels of tau phosphorylation at the sites of Thr205, Thr231 and Ser396, whereas highly induced tau phosphorylation was abolished by intranasal administration of DFO in APP/PS1 transgenic mice.	Iron	10-14	presenilin 1	Mus musculus	221-224
23262393-5	2013	Moreover, DFO intranasal administration also decreases Fe-induced the activities of cyclin-dependent kinase 5 (CDK5) and glycogen synthase kinase 3beta (GSK3beta), which in turn suppressing tau phosphorylation.	Iron	55-57	glycogen synthase kinase 3 beta	Mus musculus	121-151
26462907-12	2015	Sex specific differences were found; Co, Cu, Fe, Zn, and Ni were positively correlated with 11beta-HSD2 expression in males only, no significant correlations were found in the female only sample.	Iron	45-47	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	92-103
23166355-9	2013	Heterologous expression of MEB1 and MEB2 in yeast (Saccharomyces cerevisiae) suppresses iron and manganese toxicity, suggesting that MEB1 and MEB2 are metal transporters.	Iron	88-92	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	36-40
23166355-9	2013	Heterologous expression of MEB1 and MEB2 in yeast (Saccharomyces cerevisiae) suppresses iron and manganese toxicity, suggesting that MEB1 and MEB2 are metal transporters.	Iron	88-92	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	142-146
26169129-0	2015	Expression and purification of a new recombinant camel hepcidin able to promote the degradation of the iron exporter ferroportin1.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	55-63
23536837-1	2013	Hepcidin, a 25-amino acid peptide hormone, is the principal regulator of plasma iron concentrations.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
23536837-2	2013	Hepcidin binding to its receptor, the iron exporter ferroportin, induces ferroportin internalization and degradation, thus blocking iron efflux from cells into plasma.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	0-8
23536837-2	2013	Hepcidin binding to its receptor, the iron exporter ferroportin, induces ferroportin internalization and degradation, thus blocking iron efflux from cells into plasma.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	0-8
26169129-1	2015	Hepcidin, a 25-amino-acid and highly disulfide bonded antimicrobial peptide, is the central regulator of iron homeostasis.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
26392237-2	2015	Out of three by-products of HO-1 activity, biliverdin, iron ions and carbon monoxide (CO), the latter was mostly shown to mediate many beneficial HO-1 effects, including protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis.	Iron	55-59	heme oxygenase 1	Homo sapiens	146-150
23437357-0	2013	N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.	Iron	126-130	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	86-91
23437357-6	2013	Instead, eIF3a is a vital constituent of stress granules and appears to act, in part, by differentially regulating specific mRNAs during iron depletion.	Iron	137-141	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	9-14
23437357-7	2013	Considering this, we investigated eIF3a"s role in modulating iron-regulated genes/proteins that are critically involved in proliferation and metastasis.	Iron	61-65	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	34-39
23437357-8	2013	In this study, eIF3a was down-regulated and recruited into stress granules by iron depletion as well as by the classical stress-inducers, hypoxia and tunicamycin.	Iron	78-82	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	15-20
23437357-9	2013	Iron depletion also increased expression of the metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), and a known downstream repressed target of eIF3a, namely the cyclin-dependent kinase inhibitor, p27(kip1).	Iron	0-4	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	157-162
26289639-0	2015	Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	31-39
23437357-9	2013	Iron depletion also increased expression of the metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), and a known downstream repressed target of eIF3a, namely the cyclin-dependent kinase inhibitor, p27(kip1).	Iron	0-4	cyclin dependent kinase inhibitor 1B	Homo sapiens	175-219
23437357-11	2013	Importantly, eIF3a positively regulated NDRG1 expression and negatively regulated p27(kip1) expression during iron depletion.	Iron	110-114	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	13-18
23437357-11	2013	Importantly, eIF3a positively regulated NDRG1 expression and negatively regulated p27(kip1) expression during iron depletion.	Iron	110-114	cyclin dependent kinase inhibitor 1B	Homo sapiens	82-90
26289639-1	2015	Iron supplements acutely increase hepcidin, but the duration and magnitude of the increase, its dose dependence, and its effects on subsequent iron absorption have not been characterized in humans.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	34-42
23375327-4	2013	We studied correlations of hemojuvelin with markers of iron status and of inflammation among 61 prevalent kidney allograft recipients and 136 prevalent heart transplant recipients.	Iron	55-59	hemojuvelin BMP co-receptor	Homo sapiens	27-38
26289639-3	2015	We investigated whether the acute iron-induced increase in hepcidin influences iron absorption of successive daily iron doses and twice-daily iron doses.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	59-67
23375327-11	2013	CONCLUSIONS: Elevated hemojuvelin as well as hepcidin levels in kidney or heart transplant recipients may be due to the impaired kidney function and disturbed iron status frequently encountered among this population.	Iron	159-163	hemojuvelin BMP co-receptor	Homo sapiens	22-33
23375327-11	2013	CONCLUSIONS: Elevated hemojuvelin as well as hepcidin levels in kidney or heart transplant recipients may be due to the impaired kidney function and disturbed iron status frequently encountered among this population.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	45-53
26289639-3	2015	We investigated whether the acute iron-induced increase in hepcidin influences iron absorption of successive daily iron doses and twice-daily iron doses.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	59-67
26289639-3	2015	We investigated whether the acute iron-induced increase in hepcidin influences iron absorption of successive daily iron doses and twice-daily iron doses.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	59-67
26358293-0	2015	PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation.	Iron	51-55	ras related dexamethasone induced 1	Homo sapiens	32-39
23231648-0	2012	"Iron-saturated" bovine lactoferrin improves the chemotherapeutic effects of tamoxifen in the treatment of basal-like breast cancer in mice.	Iron	1-5	lactotransferrin	Bos taurus	24-35
23231648-2	2012	This study sought to investigate whether oral iron-saturated bovine lactoferrin (Fe-Lf), a natural product which enhances chemotherapy, could improve the chemotherapeutic effects of tamoxifen in the treatment of ER-negative breast cancers.	Iron	46-50	lactotransferrin	Bos taurus	68-79
26358293-1	2015	Dexras1 is a small GTPase and plays a central role in neuronal iron trafficking.	Iron	63-67	ras related dexamethasone induced 1	Homo sapiens	0-7
23010583-8	2012	Iron-induced oxidative stress promoted an increased localization of PLD1 in membrane rafts, whereas PLD2 was excluded from these domains and appeared to be involved in glutamate transporter function.	Iron	0-4	phospholipase D2	Rattus norvegicus	100-104
26358293-3	2015	Here we report that Dexras1 is phosphorylated by protein kinase A (PKA) on serine 253, leading to a suppression of iron influx.	Iron	115-119	ras related dexamethasone induced 1	Homo sapiens	20-27
22639386-4	2012	Iron deposition was observed in both the hippocampal CA1 area and cerebral cortex, and was correlated with localized neuronal death and increased lipid peroxidation.	Iron	0-4	carbonic anhydrase 1	Rattus norvegicus	53-56
26431210-11	2015	Iron level is positively correlated with the levels of NO and IL-1beta in PD group.	Iron	0-4	interleukin 1 alpha	Homo sapiens	62-70
22945239-4	2012	Addition of exogenous iron or zinc ion in the media produces mitoNEET bound with a [2Fe-2S] cluster or zinc, respectively.	Iron	22-26	CDGSH iron sulfur domain 1	Homo sapiens	61-69
26517908-4	2015	In particular, ABC subfamily B member 7 (ABCB7) and its homologues in yeast and plants are required for iron-sulfur (Fe-S) cluster biosynthesis outside of the mitochondria, whereas ABCB10 is involved in haem biosynthesis.	Iron	117-121	ATP binding cassette subfamily B member 7	Homo sapiens	41-46
23053592-0	2012	Should we reconsider iron administration based on prevailing ferritin and hepcidin concentrations?	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	74-82
23053592-5	2012	Hepcidin reduces the abundance of iron transport proteins which facilitate iron absorption from the gut and iron mobilization from macrophages.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
23053592-5	2012	Hepcidin reduces the abundance of iron transport proteins which facilitate iron absorption from the gut and iron mobilization from macrophages.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
23053592-6	2012	Serum hepcidin is mainly modulated by iron stores, as is serum ferritin.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	6-14
26211743-0	2015	Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model.	Iron	31-35	thromboxane A synthase 1	Rattus norvegicus	18-24
23053592-7	2012	High hepcidin or ferritin levels block intestinal iron absorption and iron recycling in macrophages and decrease iron availability for erythropoiesis, leading to FID.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	5-13
23053592-7	2012	High hepcidin or ferritin levels block intestinal iron absorption and iron recycling in macrophages and decrease iron availability for erythropoiesis, leading to FID.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	5-13
23053592-7	2012	High hepcidin or ferritin levels block intestinal iron absorption and iron recycling in macrophages and decrease iron availability for erythropoiesis, leading to FID.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	5-13
23053592-8	2012	Iron administration, especially IVFe, increases hepcidin levels and concomitantly inhibits iron supply to erythroid cells.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	48-56
26164493-1	2015	The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research and discoveries in the iron field have dramatically changed our understanding of human disorders of iron metabolism.	Iron	189-193	hepcidin antimicrobial peptide	Homo sapiens	17-25
23179904-0	2012	Acidic milieu augments the expression of hepcidin, the central regulator of iron homeostasis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	41-49
23179904-1	2012	Hepcidin is the central regulator of body iron homeostasis, and dysregulation of hepcidin expression causes various clinical disorders, such as anemia and hemochromatosis.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
23179904-2	2012	Various stimuli, including iron load and interleukin-6, are involved in the regulation of hepcidin expression.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	90-98
26164493-2	2015	Today, hereditary hemochromatosis, the paradigmatic iron-loading disorder, is recognized as an endocrine disease due to the genetic loss of hepcidin, the iron hormone produced by the liver.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	140-148
23114598-2	2012	Hepcidin, a small polypeptide produced by hepatocytes, plays a central role in regulating iron uptake by promoting internalization and degradation of ferroportin, the only known cellular iron exporter.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
23114598-2	2012	Hepcidin, a small polypeptide produced by hepatocytes, plays a central role in regulating iron uptake by promoting internalization and degradation of ferroportin, the only known cellular iron exporter.	Iron	187-191	hepcidin antimicrobial peptide	Homo sapiens	0-8
23114598-3	2012	Hypoxia suppresses hepcidin, thereby enhancing intestinal iron uptake and release from internal stores.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	19-27
26164493-2	2015	Today, hereditary hemochromatosis, the paradigmatic iron-loading disorder, is recognized as an endocrine disease due to the genetic loss of hepcidin, the iron hormone produced by the liver.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	140-148
26164493-4	2015	It is caused by mutations that affect any of the proteins that help hepcidin to monitor serum iron, including HFE and, in rarer instances, transferrin-receptor 2 and hemojuvelin, or make its receptor ferroportin, resistant to the hormone.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	68-76
26253232-6	2015	Mutants harboring defects in the RING DOMAIN LIGASE1 (RGLG1)(1) and RING DOMAIN LIGASE2 (RGLG2) showed a pleiotropic phenotype that resembled iron-deficient plants with reduced trichome density and the formation of branched root hairs.	Iron	142-146	RING domain ligase1	Arabidopsis thaliana	54-59
22836384-6	2012	Changes in iron metabolism are the leading causes of anemia in RA patients and mainly induced by the altered synthesis and function of hepcidin and ferroportin.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	135-143
22836384-7	2012	Hepcidin, a peptide produced in the liver and immunocompetent cells, impairs the expression of ferroportin on iron-secreting cells, thus reducing iron bioavailability.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	0-8
22836384-7	2012	Hepcidin, a peptide produced in the liver and immunocompetent cells, impairs the expression of ferroportin on iron-secreting cells, thus reducing iron bioavailability.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	0-8
26253232-7	2015	Proteomic and transcriptomic profiling of rglg1 rglg2 double mutants revealed that the functional RGLG protein is required for the regulation of a large set of iron-responsive proteins including the coordinated expression of ribosomal proteins.	Iron	160-164	RING domain ligase1	Arabidopsis thaliana	42-47
26302480-2	2015	We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	285-289	glutaredoxin 3	Homo sapiens	50-64
23034726-2	2012	It was found that though these iron-based superconductors are chemically similar, they adopted distinct structural phase transitions: P4/nmm Cmcm P3m1 for NaFeAs, P4/nmm Cmcm I4mm for LiFeP, and P4/nmm P3m1  I4mm P6(3)/mmc for LiFeAs under high pressure.	Iron	31-35	solute carrier family 10 member 4	Homo sapiens	195-210
26302480-2	2015	We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	285-289	glutaredoxin 3	Homo sapiens	66-70
26302480-2	2015	We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	285-289	glutaredoxin 3	Homo sapiens	175-179
26268656-2	2015	Among those is hepcidin, a small cysteine-rich antimicrobial peptide that is also the key regulator of iron metabolism.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	15-23
22789477-1	2012	Human Lactoferrin (hLF) is an iron-binding protein with multiple physiological functions.	Iron	30-34	HLF transcription factor, PAR bZIP family member	Homo sapiens	19-22
26268656-3	2015	Although most mammals possess a single hepcidin gene, with a dual role in both iron metabolism regulation and antimicrobial response, many teleost fish present multiple copies of hepcidin, most likely because of genome duplications and positive Darwinian selection, suggesting that different hepcidins may perform different functions.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	39-47
22932892-1	2012	The peptide hormone hepcidin regulates mammalian iron homeostasis by blocking ferroportin-mediated iron export from macrophages and the duodenum.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	20-28
26268656-9	2015	In conclusion, teleost fish that present two hepcidin types show a degree of subfunctionalization of its functions, with hamp1 more involved in the regulation of iron metabolism and hamp2 mostly performing an antimicrobial role.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	45-53
22932892-1	2012	The peptide hormone hepcidin regulates mammalian iron homeostasis by blocking ferroportin-mediated iron export from macrophages and the duodenum.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	20-28
26209053-3	2015	The present study investigates the role of frataxin (FXN), a mitochondrial iron-sulfur biogenesis protein, and its role in development of DOX-mediated mitochondrial dysfunction.	Iron	75-79	frataxin	Rattus norvegicus	43-51
22893705-1	2012	Hemojuvelin (HJV) and matriptase-2 (MT2) are co-expressed in hepatocytes, and both are essential for systemic iron homeostasis.	Iron	110-114	hemojuvelin BMP co-receptor	Homo sapiens	0-11
22893705-1	2012	Hemojuvelin (HJV) and matriptase-2 (MT2) are co-expressed in hepatocytes, and both are essential for systemic iron homeostasis.	Iron	110-114	hemojuvelin BMP co-receptor	Homo sapiens	13-16
26209053-3	2015	The present study investigates the role of frataxin (FXN), a mitochondrial iron-sulfur biogenesis protein, and its role in development of DOX-mediated mitochondrial dysfunction.	Iron	75-79	frataxin	Rattus norvegicus	53-56
26209053-5	2015	Furthermore, we also observed significant reduction in FXN expression in DOX-treated animals and H9C2 cardiomyoblast cell lines, resulting in increased mitochondrial iron accumulation and the ensuing ROS formation.	Iron	166-170	frataxin	Rattus norvegicus	55-58
26209053-8	2015	To better understand the cardioprotective role of FXN against DOX, we constructed FXN overexpressing cardiomyoblasts, which displayed cardioprotection against mitochondrial iron accumulation, ROS formation, and reduction of mitochondrial bioenergetics.	Iron	173-177	frataxin	Rattus norvegicus	82-85
26288393-0	2015	Depleted iron stores and iron deficiency anemia associated with reduced ferritin and hepcidin and elevated soluble transferrin receptors in a multiethnic group of preschool-age children.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	85-93
22975354-3	2012	Real-time PCR analyses of the human PDL revealed abundant expression of ferritin light polypeptide (FTL) and ferritin heavy polypeptide (FTH), which encode the highly-conserved iron storage protein, ferritin.	Iron	177-181	ferritin heavy chain 1	Homo sapiens	109-135
22975354-3	2012	Real-time PCR analyses of the human PDL revealed abundant expression of ferritin light polypeptide (FTL) and ferritin heavy polypeptide (FTH), which encode the highly-conserved iron storage protein, ferritin.	Iron	177-181	ferritin heavy chain 1	Homo sapiens	137-140
22879583-5	2012	Histological analyses revealed iron accumulations in the intima, in colocalization with vascular cell adhesion molecule-1-expressing macrophages and endothelial cells.	Iron	31-35	vascular cell adhesion molecule 1	Mus musculus	88-121
25774043-0	2015	Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	88-96
26457280-8	2015	RESULTS: ALT levels increased depending on cumulative iron dose, with significant differences between days 1 and 7 for mice loaded with 200 mg of iron (P&lt;0.01).	Iron	54-58	glutamic pyruvic transaminase, soluble	Mus musculus	9-12
22541685-2	2012	Hepcidin is a regulator of iron homeostasis and has a major role in the anemia of chronic disease (ACD).	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
26457280-8	2015	RESULTS: ALT levels increased depending on cumulative iron dose, with significant differences between days 1 and 7 for mice loaded with 200 mg of iron (P&lt;0.01).	Iron	146-150	glutamic pyruvic transaminase, soluble	Mus musculus	9-12
26617777-3	2015	Ferroportin 1 (FPN1) is the unique exporter of ferrous iron from mammalian cells.	Iron	47-59	solute carrier family 40 member 1	Homo sapiens	0-13
26617777-3	2015	Ferroportin 1 (FPN1) is the unique exporter of ferrous iron from mammalian cells.	Iron	47-59	solute carrier family 40 member 1	Homo sapiens	15-19
22541685-10	2012	CONCLUSIONS: The close association between hepcidin and serum ferritin, oral iron and hsCRP indicates that it plays a key role in the pathogenesis of anemia in patients with CKD not receiving dialysis.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	43-51
25727755-1	2015	Transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1) are important proteins for cellular iron uptake, and both are regulated transcriptionally through the binding of hypoxia-inducible factor 1 (HIF-1) to hypoxia-responsive elements (HREs) under hypoxic conditions.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	32-60
25727755-1	2015	Transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1) are important proteins for cellular iron uptake, and both are regulated transcriptionally through the binding of hypoxia-inducible factor 1 (HIF-1) to hypoxia-responsive elements (HREs) under hypoxic conditions.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	62-66
25727755-3	2015	In iron-deficient cells, IRP1-IRE interactions stabilize TfR1 and DMT1 mRNAs, enhancing iron uptake.	Iron	3-7	solute carrier family 11 member 2	Homo sapiens	66-70
22732356-1	2012	BACKGROUND AND AIMS: Hepcidin plays a crucial role in iron metabolism, preventing its absorption at the basolateral enterocyte membrane.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	21-29
22732356-5	2012	We intended to assess whether iron overload related to alcohol ingestion was caused by hepcidin-impaired expression by determining hepcidin mRNA expression and relating it to iron stores, both in alcoholic patients and in normal controls.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	87-95
25727755-3	2015	In iron-deficient cells, IRP1-IRE interactions stabilize TfR1 and DMT1 mRNAs, enhancing iron uptake.	Iron	88-92	solute carrier family 11 member 2	Homo sapiens	66-70
22732356-14	2012	CONCLUSION: Hepcidin liver expression is inappropriately low in alcoholic patients with active alcoholism and preserved hepatic function, and we conclude that this is the mechanism for alcohol consumption-associated iron overload in humans.	Iron	216-220	hepcidin antimicrobial peptide	Homo sapiens	12-20
26301806-4	2015	Together, the results of this study provide a mechanistic connection between dietary iron and the appetite-regulating hormone leptin.	Iron	85-89	ghrelin and obestatin prepropeptide	Homo sapiens	98-125
26301810-0	2015	Adipocyte iron regulates leptin and food intake.	Iron	10-14	leptin	Mus musculus	25-31
22527885-4	2012	We have shown that depletion of the mammalian siderophore by inhibiting expression of bdh2 results in abnormal accumulation of cellular iron and mitochondrial iron deficiency.	Iron	136-140	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	86-90
26458857-1	2015	BACKGROUND/AIM: We aimed to analyze serum hepcidin level in children with chronic liver disease (CLD) and its relationship with serum cytokines level, liver function tests, hepatic iron content, and liver fibrosis.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	42-50
22527885-7	2012	In cultured cells as well as in patient samples we now demonstrate that the IRE confers iron-dependent regulation on hBDH2 and binds IRPs in RNA electrophoretic mobility shift assays.	Iron	88-92	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	117-122
22527885-8	2012	In addition, we show that the hBDH2 IRE associates with IRPs in cells and that abrogation of IRPs by RNAi eliminates the iron-dependent regulation of hBDH2 mRNA.	Iron	121-125	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	30-35
22527885-8	2012	In addition, we show that the hBDH2 IRE associates with IRPs in cells and that abrogation of IRPs by RNAi eliminates the iron-dependent regulation of hBDH2 mRNA.	Iron	121-125	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	150-155
22527885-9	2012	The key physiologic implication is that iron-mediated post-transcriptional regulation of hBDH2 controls mitochondrial iron homeostasis in human cells.	Iron	40-44	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	89-94
22527885-9	2012	The key physiologic implication is that iron-mediated post-transcriptional regulation of hBDH2 controls mitochondrial iron homeostasis in human cells.	Iron	118-122	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	89-94
26311037-0	2015	Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	130-138
22881289-4	2012	To gain a better appreciation of the role of glial HO-1 in vivo, we probed for aberrant brain iron deposition using Perls" method and dynamic secondary ion mass spectrometry in novel, conditional GFAP.HMOX1 transgenic mice that selectively over-express human HO-1 in the astrocytic compartment.	Iron	94-98	glial fibrillary acidic protein	Mus musculus	196-200
22881289-5	2012	At 48 weeks, the GFAP.HMOX1 mice exhibited increased deposits of glial iron in hippocampus and other subcortical regions without overt changes in iron-regulatory and iron-binding proteins relative to age-matched wild-type animals.	Iron	71-75	glial fibrillary acidic protein	Mus musculus	17-21
26322167-2	2015	Over the last decade, the liver peptide "hepcidin" has emerged as the body"s key irons store regulator.	Iron	81-86	hepcidin antimicrobial peptide	Homo sapiens	41-49
23104832-4	2012	AE7 is part of a protein complex with CIA1, NAR1, and MET18, which are highly conserved in eukaryotes and are involved in the biogenesis of cytosolic and nuclear Fe-S proteins.	Iron	162-166	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	38-42
23104832-6	2012	Additionally, mutations in the gene encoding the mitochondrial ATP binding cassette transporter ATM3/ABCB25, which is required for the activity of cytosolic Fe-S enzymes in Arabidopsis, also result in defective genome integrity similar to that of ae7-1.	Iron	157-161	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	96-100
23104832-6	2012	Additionally, mutations in the gene encoding the mitochondrial ATP binding cassette transporter ATM3/ABCB25, which is required for the activity of cytosolic Fe-S enzymes in Arabidopsis, also result in defective genome integrity similar to that of ae7-1.	Iron	157-161	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	101-107
26322167-4	2015	Last year, evidence was provided, that a previously described myokine "myonectin" may also function as the long sought erythroid regulator of iron.	Iron	142-146	erythroferrone	Homo sapiens	71-81
22998440-1	2012	BACKGROUND: Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	53-61
26270345-3	2015	However, it appears that the toxic effects of heme are exerted by "loose" (probably intralysosomal) iron because cytotoxic effects of heme are lessened by pre-incubation of HO-1 deficient cells with desferrioxamine (which localizes preferentially in the lysosomal compartment).	Iron	100-104	heme oxygenase 1	Homo sapiens	173-177
22998440-1	2012	BACKGROUND: Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	53-61
22998440-2	2012	Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations are associated with a severe form of iron overload (Juvenile haemochromatosis).	Iron	191-195	hemojuvelin BMP co-receptor	Homo sapiens	0-11
22998440-2	2012	Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations are associated with a severe form of iron overload (Juvenile haemochromatosis).	Iron	191-195	hemojuvelin BMP co-receptor	Homo sapiens	13-16
22998440-2	2012	Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations are associated with a severe form of iron overload (Juvenile haemochromatosis).	Iron	191-195	hemojuvelin BMP co-receptor	Homo sapiens	140-143
26270641-1	2015	Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
26629542-8	2015	Given that iron absorption is impaired by hepcidin, our data suggest that asymptomatic and febrile malaria contribute to the high burden of ID seen in African children.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	42-50
22954389-7	2012	Moreover, the rate constants determined in the oxidation of various benzyl alcohol derivatives by [Fe(IV)(O)(N4Py)](2+) in the presence of Sc(OTf)(3) (10 mM) were compared with those of Sc(3+)-coupled electron transfer from one-electron reductants to [Fe(IV)(O)(N4Py)](2+) at the same driving force of electron transfer.	Iron	99-101	POU class 5 homeobox 1	Homo sapiens	139-148
26088136-2	2015	Here we report that Prx1 proteins from Tetraodon nigroviridis and humans also possess a previously unknown catalase-like activity that is independent of Cys residues and reductants but dependent on iron.	Iron	198-202	peroxiredoxin 1	Homo sapiens	20-24
22360429-1	2012	AIMS: The aim of the present study was to evaluate the therapeutic effect of the novel neuroprotective multi-target nontoxic, lipophilic, brain permeable monoamine oxidase inhibitor and iron chelating-radical scavenging drug, M30, on the neuropathology and deficits of spatial learning and memory in amyloid precursor protein (APP) and presenilin 1 (PS1) double-transgenic (Tg) Alzheimer"s disease (AD) mice.	Iron	186-190	amyloid beta (A4) precursor protein	Mus musculus	300-325
22360429-1	2012	AIMS: The aim of the present study was to evaluate the therapeutic effect of the novel neuroprotective multi-target nontoxic, lipophilic, brain permeable monoamine oxidase inhibitor and iron chelating-radical scavenging drug, M30, on the neuropathology and deficits of spatial learning and memory in amyloid precursor protein (APP) and presenilin 1 (PS1) double-transgenic (Tg) Alzheimer"s disease (AD) mice.	Iron	186-190	presenilin 1	Mus musculus	336-348
25605615-9	2015	CONCLUSION: GNPAT p.D519G is associated with a high-iron phenotype in HFE C282Y homozygotes and may participate in hepcidin regulation.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	115-123
22360429-1	2012	AIMS: The aim of the present study was to evaluate the therapeutic effect of the novel neuroprotective multi-target nontoxic, lipophilic, brain permeable monoamine oxidase inhibitor and iron chelating-radical scavenging drug, M30, on the neuropathology and deficits of spatial learning and memory in amyloid precursor protein (APP) and presenilin 1 (PS1) double-transgenic (Tg) Alzheimer"s disease (AD) mice.	Iron	186-190	presenilin 1	Mus musculus	350-353
22360429-7	2012	Here, for the first time, we demonstrated that, when systemically administered to APP/PS1 Tg mice, our novel multifunctional iron chelating/radical scavenging compound, M30, effectively reduced Abeta accumulation and tau phosphorylation, and attenuated memory deficits.	Iron	125-129	presenilin 1	Mus musculus	86-89
22360429-7	2012	Here, for the first time, we demonstrated that, when systemically administered to APP/PS1 Tg mice, our novel multifunctional iron chelating/radical scavenging compound, M30, effectively reduced Abeta accumulation and tau phosphorylation, and attenuated memory deficits.	Iron	125-129	amyloid beta (A4) precursor protein	Mus musculus	194-199
26041677-10	2015	The postintervention serum iron response was lower (P &lt; 0.0001) in the LP group than in the HP group after controlling for the baseline serum iron response and hepcidin concentration, reflecting in a 64% lower AUC.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	163-171
22863525-6	2012	Molecular modeling suggested that the most probable binding poses of the methylthiostilbene derivatives in CYP1A2 active sites are those with the methylthio substituent directed towards the heme iron.	Iron	195-199	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	107-113
25494391-4	2015	Hepcidin is the central regulator of systemic iron homeostasis and exerts its function by controlling the presence of the iron exporter ferroportin on the cell membrane.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
22924847-7	2012	Patients with the SLC40A1 genotype were affected by mild iron overload (ferroportin A) or severe iron overload (ferroportin B).	Iron	57-61	solute carrier family 40 member 1	Homo sapiens	18-25
22924847-7	2012	Patients with the SLC40A1 genotype were affected by mild iron overload (ferroportin A) or severe iron overload (ferroportin B).	Iron	97-101	solute carrier family 40 member 1	Homo sapiens	18-25
22789928-12	2012	The MMP-9 and EGF upregulation was linked to the presence of iron deposition in both groups, whereas increased levels of EGF were connected with the presence of myopic regression after LASIK.	Iron	61-65	epidermal growth factor	Homo sapiens	14-17
22706208-3	2012	To this end, we investigated the role of the iron storage protein bacterioferritin using transcriptomic and physiological approaches.	Iron	45-49	bfr	Desulfovibrio vulgaris str. Hildenborough	66-82
22706208-7	2012	Altogether the data revealed a previously unrecognized ability for the iron storage bacterioferritin to contribute to the oxygen tolerance exhibited by D. vulgaris.	Iron	71-75	bfr	Desulfovibrio vulgaris str. Hildenborough	84-100
22294463-5	2012	In this paper, we review current literature on transferrin deficiency and present our recent findings, including potential overlaps between transferrin, iron and manganese in the regulation of hepcidin expression.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	193-201
22310887-1	2012	Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin cycle.	Iron	67-71	solute carrier family 11 member 2	Homo sapiens	32-36
22310887-1	2012	Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin cycle.	Iron	106-110	solute carrier family 11 member 2	Homo sapiens	32-36
22211782-4	2012	Cellular iron export is mediated by the membrane iron transporter ferroportin 1, in conjunction with an iron oxidase.	Iron	9-13	solute carrier family 40 member 1	Homo sapiens	66-79
22211782-6	2012	The liver-derived peptide hepcidin binds to ferroportin 1 and removes it from the cell surface, thus reducing iron donation to the plasma.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	26-34
22211782-6	2012	The liver-derived peptide hepcidin binds to ferroportin 1 and removes it from the cell surface, thus reducing iron donation to the plasma.	Iron	110-114	solute carrier family 40 member 1	Homo sapiens	44-57
22211782-7	2012	The levels of hepcidin, in turn, reflect body iron requirements.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	14-22
22211782-8	2012	At the cellular level, ferroportin 1 can also be regulated independently of hepcidin by hypoxia-inducible factors and the iron regulatory proteins.	Iron	122-126	solute carrier family 40 member 1	Homo sapiens	23-36
22211782-9	2012	The hepcidin-ferroportin axis plays a critical role in regulating body iron homeostasis.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	4-12
22587389-4	2012	One of the key enzymes that control monocyte and DC function is haem oxygenase-1 (HO-1), which catalyses the degradation of the haem group into biliverdin, carbon monoxide and free iron.	Iron	181-185	heme oxygenase 1	Homo sapiens	64-80
22587389-4	2012	One of the key enzymes that control monocyte and DC function is haem oxygenase-1 (HO-1), which catalyses the degradation of the haem group into biliverdin, carbon monoxide and free iron.	Iron	181-185	heme oxygenase 1	Homo sapiens	82-86
22632844-0	2012	Are extrinsic black stains of teeth iron-saturated bovine lactoferrin and a sign of iron deficient anemia or iron overload?	Iron	36-40	lactotransferrin	Bos taurus	58-69
22632844-4	2012	Lactoferrin is the major iron-binding protein, constituent of milk, stays almost intact during cheese making and has antibacterial activity against dental cavity-inducing Streptococcus mutans.	Iron	25-29	lactotransferrin	Bos taurus	0-11
22632844-5	2012	Lactoferrin has a high affinity for iron and whenever it is present it will bind iron and release it only in values of pH&lt;4.	Iron	36-40	lactotransferrin	Bos taurus	0-11
22632844-5	2012	Lactoferrin has a high affinity for iron and whenever it is present it will bind iron and release it only in values of pH&lt;4.	Iron	81-85	lactotransferrin	Bos taurus	0-11
22632844-9	2012	Iron must be in sufficient amounts in saliva so that lactoferrin can bind it and as a result making the black stains appear.	Iron	0-4	lactotransferrin	Bos taurus	53-64
22632844-11	2012	In conclusion, extrinsic black stains of teeth may be iron-saturated bovine lactoferrin and a sign of iron deficient anemia or iron overload if no iron supplements are taken or individuals have no frequent gingival bleeding.	Iron	54-58	lactotransferrin	Bos taurus	76-87
22696679-9	2012	In addition, Met31p and Met32p appear to regulate iron-sulfur cluster biogenesis through direct and indirect mechanisms and have distinguishable target specificities.	Iron	50-54	Met31p	Saccharomyces cerevisiae S288C	13-19
22634399-0	2012	Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake.	Iron	17-21	solute carrier family 11 member 2	Homo sapiens	65-69
22302482-1	2012	Heme oxygenase-1 (HO-1) catabolizes heme into carbon monoxide, biliverdin, and free iron which mediate its protective effect against oxidative stress.	Iron	84-88	heme oxygenase 1	Homo sapiens	0-16
22302482-1	2012	Heme oxygenase-1 (HO-1) catabolizes heme into carbon monoxide, biliverdin, and free iron which mediate its protective effect against oxidative stress.	Iron	84-88	heme oxygenase 1	Homo sapiens	18-22
22546244-5	2012	RR data revealed that entrapment of oxidized Cyt c into the Q(230) phase at 1 wt.% content results in near complete reduction of central iron ion of the heme group, while its low-spin state and six-ligand coordination configuration are preserved.	Iron	137-141	cytochrome c, somatic	Equus caballus	45-50
22580341-0	2012	A novel strategy of natural plant ferritin to protect DNA from oxidative damage during iron oxidation.	Iron	87-91	ferritin-1, chloroplastic	Glycine max	34-42
22580341-4	2012	Interestingly, naturally occurring soybean seed ferritin (SSF), a heteropolymer with an H-1/H-2 ratio of 1 to 1 in the apo form, completely protected DNA from oxidative damage during iron oxidative deposition into protein, and a similar result was obtained with its recombinant form, but not with its homopolymeric counterparts, apo rH-1 and apo rH-2.	Iron	183-187	ferritin-1, chloroplastic	Glycine max	48-56
22797994-5	2012	A possible mechanistic link between malaria, poor absorption of iron, and anemia is provided by recent research on hepcidin, the human iron control hormone.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	115-123
22797994-5	2012	A possible mechanistic link between malaria, poor absorption of iron, and anemia is provided by recent research on hepcidin, the human iron control hormone.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	115-123
25494391-4	2015	Hepcidin is the central regulator of systemic iron homeostasis and exerts its function by controlling the presence of the iron exporter ferroportin on the cell membrane.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	0-8
25494391-5	2015	Hepcidin binding induces ferroportin degradation, thus leading to cellular iron retention and decreased levels of circulating iron.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
25494391-5	2015	Hepcidin binding induces ferroportin degradation, thus leading to cellular iron retention and decreased levels of circulating iron.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	0-8
25494391-7	2015	The iron needed for hemoglobin synthesis is ensured by inhibiting hepcidin to increase ferroportin activity and iron availability and hence to make certain that efficient blood oxygen transport occurs for aerobic exercise.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	66-74
25494391-7	2015	The iron needed for hemoglobin synthesis is ensured by inhibiting hepcidin to increase ferroportin activity and iron availability and hence to make certain that efficient blood oxygen transport occurs for aerobic exercise.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	66-74
26243212-0	2015	Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E. Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	9-17
26243212-1	2015	Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	36-44
26243212-2	2015	In this study performed on noniron deficient and well-trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28-days supplementation period with vitamins C (500 mg/day) and E (400 IU/day).	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	88-96
26055723-0	2015	Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	33-41
26055723-3	2015	Hepcidin, a molecule first characterized as an antimicrobial peptide, plays a critical role in the regulation of iron homeostasis.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	0-8
26055723-4	2015	Multiple stimuli positively influence the expression of hepcidin, including iron, inflammation, and infection by pathogens.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	56-64
26055723-5	2015	In this Minireview, I will discuss how inflammation regulates hepcidin transcription, allowing for sufficient concentrations of iron for organismal needs while sequestering the metal from infectious pathogens.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	62-70
26251568-3	2015	Lactoferrin exists in various forms depending on its iron saturation.	Iron	53-57	lactotransferrin	Bos taurus	0-11
26197432-2	2015	However, in some pathological conditions, such as hereditary hemochromatosis type 1 (HH1), iron overload induces the production of reactive oxygen species that may lead to lipid peroxidation and a change in the plasma-membrane lipid profile.	Iron	91-95	sodium voltage-gated channel alpha subunit 5	Homo sapiens	85-88
25971965-1	2015	Members of the Zrt and Irt protein (ZIP) family are a central participant in transition metal homeostasis as they function to increase the cytosolic concentration of zinc and/or iron.	Iron	178-182	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	15-34
25971965-1	2015	Members of the Zrt and Irt protein (ZIP) family are a central participant in transition metal homeostasis as they function to increase the cytosolic concentration of zinc and/or iron.	Iron	178-182	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	36-39
26192321-1	2015	In Drosophila melanogaster, iron is stored in the cellular endomembrane system inside a protein cage formed by 24 ferritin subunits of two types (Fer1HCH and Fer2LCH) in a 1:1 stoichiometry.	Iron	28-32	Ferritin 2 light chain homologue	Drosophila melanogaster	158-165
26124130-0	2015	Maternal intestinal HIF-2alpha is necessary for sensing iron demands of lactation in mice.	Iron	56-60	endothelial PAS domain protein 1	Mus musculus	20-30
26124130-3	2015	During lactation, intestinal HIF-2alpha is highly increased, leading to an adaptive induction of apical and basolateral iron transport genes.	Iron	120-124	endothelial PAS domain protein 1	Mus musculus	29-39
26124130-7	2015	Increasing intestinal iron absorption by activation of HIF-2alpha or parenteral administration of iron-dextran in HIF-2alpha knockout mothers ameliorated anemia and restored neonatal development and adult cognitive functions.	Iron	22-26	endothelial PAS domain protein 1	Mus musculus	55-65
26124130-7	2015	Increasing intestinal iron absorption by activation of HIF-2alpha or parenteral administration of iron-dextran in HIF-2alpha knockout mothers ameliorated anemia and restored neonatal development and adult cognitive functions.	Iron	22-26	endothelial PAS domain protein 1	Mus musculus	114-124
26185605-1	2015	Hepcidin is a peptide hormone with both paracrine and endocrine functions that help in maintaining body iron stores.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	0-8
26185605-2	2015	Type 2 diabetes (T2D) is one of the sequelae of excess body iron stores; thus, iron regulatory hormone hepcidin may have a direct or at least an indirect role in the aetiopathogenesis of T2D.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	103-111
26185605-2	2015	Type 2 diabetes (T2D) is one of the sequelae of excess body iron stores; thus, iron regulatory hormone hepcidin may have a direct or at least an indirect role in the aetiopathogenesis of T2D.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	103-111
26185605-5	2015	Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	66-74
26185605-5	2015	Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10.	Iron	134-138	solute carrier family 40 member 1	Homo sapiens	84-97
26070639-14	2015	CONCLUSIONS: The results indicate that SlbHLH068, as a putative transcription factor, is involved in iron homeostasis in tomato via an interaction with FER.	Iron	101-105	transcription factor bHLH100	Solanum lycopersicum	39-48
26035384-2	2015	In this study, we present data from several Drosophila models of neurodegenerative proteinopathies indicating that the interaction between iron and amyloid beta peptide (Abeta) is specific and is not seen for other aggregation-prone polypeptides.	Iron	139-143	beta amyloid protein precursor-like	Drosophila melanogaster	170-175
22428539-0	2012	A Chinese family carrying novel mutations in SEC23B and HFE2, the genes responsible for congenital dyserythropoietic anaemia II (CDA II) and primary iron overload, respectively.	Iron	149-153	SEC23 homolog B, COPII coat complex component	Homo sapiens	45-51
22428539-0	2012	A Chinese family carrying novel mutations in SEC23B and HFE2, the genes responsible for congenital dyserythropoietic anaemia II (CDA II) and primary iron overload, respectively.	Iron	149-153	hemojuvelin BMP co-receptor	Homo sapiens	56-60
26035384-3	2015	The interaction with iron is likely to be important in the dimerisation of Abeta and is mediated by three N-terminal histidines.	Iron	21-25	beta amyloid protein precursor-like	Drosophila melanogaster	75-80
26421179-1	2015	BACKGROUND: Hepcidin is a key regulator of iron absorption in humans.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	12-20
22474169-7	2012	Oxidative injury caused by arachidonic acid and iron enhanced Fyn phosphorylation at a tyrosine residue, which was decreased by SNU1A treatment.	Iron	48-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
22589410-8	2012	These tumor cells expressed SCF and promoted BMMC recruitment in a KIT- and FES-dependent manner.	Iron	76-79	kit ligand	Mus musculus	28-31
26421179-10	2015	It seems that regulation of hepcidin in patients with Thalassemia is more affected by erythropoeitic activity than iron stores.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	28-36
25386711-6	2015	Hepcidin levels were significantly greater before and after exercise after the iron injection (P &lt; 0.05), and this was independent of changes in interleukin-6.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	0-8
22517766-3	2012	We took advantage of the low iron status of juvenile mice to characterize the regulation of Bmp6 and Hamp1 expression by iron administered in three forms: 1) ferri-transferrin (Fe-Tf), 2) ferric ammonium citrate (FAC), and 3) liver ferritin.	Iron	29-33	bone morphogenetic protein 6	Mus musculus	92-96
25386711-9	2015	This investigation suggests that iron availability supersedes inflammation in the regulation of hepcidin in IDNA endurance athletes after acute intravascular iron injection treatment.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	96-104
22517766-3	2012	We took advantage of the low iron status of juvenile mice to characterize the regulation of Bmp6 and Hamp1 expression by iron administered in three forms: 1) ferri-transferrin (Fe-Tf), 2) ferric ammonium citrate (FAC), and 3) liver ferritin.	Iron	121-125	bone morphogenetic protein 6	Mus musculus	92-96
22517766-9	2012	Removing iron from ferritin markedly decreased its effect on Bmp6 expression.	Iron	9-13	bone morphogenetic protein 6	Mus musculus	61-65
22517766-12	2012	We conclude that exogenous iron-containing ferritin upregulates hepatic Bmp6 expression, and we speculate that liver ferritin contributes to regulation of Bmp6 and, thus, Hamp1 genes.	Iron	27-31	bone morphogenetic protein 6	Mus musculus	72-76
25386711-9	2015	This investigation suggests that iron availability supersedes inflammation in the regulation of hepcidin in IDNA endurance athletes after acute intravascular iron injection treatment.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	96-104
25871543-0	2015	Expression of Malus xiaojinensis IRT1 (MxIRT1) protein in transgenic yeast cells leads to degradation through autophagy in the presence of excessive iron.	Iron	149-153	IRT1	Saccharomyces cerevisiae S288C	33-37
22682227-2	2012	The hormone hepcidin controls cellular iron export and plasma iron concentrations by binding to ferroportin and causing its internalization and degradation.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	12-20
22682227-2	2012	The hormone hepcidin controls cellular iron export and plasma iron concentrations by binding to ferroportin and causing its internalization and degradation.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	12-20
22682227-3	2012	We explored the mechanism of hepcidin-induced endocytosis of ferroportin, the key molecular event in systemic iron homeostasis.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	29-37
22682227-6	2012	Substitutions of lysines between residues 229 and 269 in the third cytoplasmic loop of ferroportin prevented hepcidin-dependent ubiquitination and endocytosis of ferroportin, and promoted cellular iron export even in the presence of hepcidin.	Iron	197-201	hepcidin antimicrobial peptide	Homo sapiens	109-117
22682227-7	2012	The human ferroportin mutation K240E, previously associated with clinical iron overload, caused hepcidin resistance in vitro by interfering with ferroportin ubiquitination.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	96-104
26074074-0	2015	Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.	Iron	0-4	NLR family, pyrin domain containing 3	Mus musculus	53-58
22332905-6	2012	Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling.	Iron	103-107	intelectin 1	Homo sapiens	39-42
22332905-6	2012	Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling.	Iron	124-128	intelectin 1	Homo sapiens	39-42
26074074-3	2015	We report that excess iron, but not other Fenton catalytic metals, induces activation of the NLRP3 inflammasome, a pathway also implicated in AMD.	Iron	22-26	NLR family, pyrin domain containing 3	Mus musculus	93-98
22332957-4	2012	Lactoferrin (Lf) is a glycoprotein of the innate immune response that sequesters iron in the mucosae.	Iron	81-85	lactotransferrin	Bos taurus	0-11
22332957-4	2012	Lactoferrin (Lf) is a glycoprotein of the innate immune response that sequesters iron in the mucosae.	Iron	81-85	lactotransferrin	Bos taurus	13-15
26074074-4	2015	Additionally, iron-induced degeneration of the retinal pigmented epithelium (RPE) is suppressed in mice lacking inflammasome components caspase-1/11 or Nlrp3 or by inhibition of caspase-1.	Iron	14-18	NLR family, pyrin domain containing 3	Mus musculus	152-157
26124661-0	2015	Oral administration of iron-saturated bovine lactoferrin-loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism.	Iron	128-132	lactotransferrin	Bos taurus	45-56
25816754-2	2015	There is a sophisticated balance of body iron metabolism of storage and transport which is regulated by several factors including the peptide hepcidin.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	142-150
22570273-6	2012	Gene expression analysis of PPAR-alpha showed that the HI group had a lower PPAR-alpha expression than H. These data show that iron, when associated with a high-fat diet, can cause increased serum cholesterol levels, possibly due to a reduction in PPAR-alpha expression.	Iron	127-131	peroxisome proliferator activated receptor alpha	Homo sapiens	28-38
22570273-6	2012	Gene expression analysis of PPAR-alpha showed that the HI group had a lower PPAR-alpha expression than H. These data show that iron, when associated with a high-fat diet, can cause increased serum cholesterol levels, possibly due to a reduction in PPAR-alpha expression.	Iron	127-131	peroxisome proliferator activated receptor alpha	Homo sapiens	76-86
22570273-6	2012	Gene expression analysis of PPAR-alpha showed that the HI group had a lower PPAR-alpha expression than H. These data show that iron, when associated with a high-fat diet, can cause increased serum cholesterol levels, possibly due to a reduction in PPAR-alpha expression.	Iron	127-131	peroxisome proliferator activated receptor alpha	Homo sapiens	76-86
25816754-3	2015	Hepcidin is the main iron regulatory molecule; it is secreted mainly by the liver and other tissues including monocytes and lymphocytes.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	0-8
25816754-6	2015	Hepcidin levels in beta-thalassemia major patients showed statistically significant decrease in comparison to the control group, and was correlated to cardiac iron stores (T2*).	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	0-8
25816754-8	2015	In conclusion; peripheral expression of hepcidin, in iron overloaded beta-thalassemia major patients, is a reflection of hepatic expression.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	40-48
22572041-4	2012	Further, female athletes may experience an elevated risk of ID and IDA, as hepcidin, a peptide hormone that inhibits iron absorption and sequesters iron in the macrophage, may rise in response to physical activity.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	75-83
26045598-0	2015	Serum hepcidin levels predict response to intravenous iron and darbepoetin in chemotherapy-associated anemia.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	6-14
22572041-4	2012	Further, female athletes may experience an elevated risk of ID and IDA, as hepcidin, a peptide hormone that inhibits iron absorption and sequesters iron in the macrophage, may rise in response to physical activity.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	75-83
22490684-1	2012	Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by beta-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	57-65
22490684-1	2012	Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by beta-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	67-71
26082716-2	2015	An additional neuroprotective mechanism of iron-chelating compounds is to regulate the transcriptional activator hypoxia-inducible factor 1alpha (HIF-1alpha).	Iron	43-47	hypoxia inducible factor 1, alpha subunit	Mus musculus	113-144
22490684-1	2012	Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by beta-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	163-167
22490684-1	2012	Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by beta-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	57-65
22490684-1	2012	Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by beta-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(th3/+) mouse.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	67-71
22503972-4	2012	Heme oxygenase 1 (HO1) degrades heme to biliverdin, carbon monoxide and free iron, and is a stress-responsive protein.	Iron	77-81	heme oxygenase 1	Homo sapiens	0-16
22503972-4	2012	Heme oxygenase 1 (HO1) degrades heme to biliverdin, carbon monoxide and free iron, and is a stress-responsive protein.	Iron	77-81	heme oxygenase 1	Homo sapiens	18-21
26082716-2	2015	An additional neuroprotective mechanism of iron-chelating compounds is to regulate the transcriptional activator hypoxia-inducible factor 1alpha (HIF-1alpha).	Iron	43-47	hypoxia inducible factor 1, alpha subunit	Mus musculus	146-156
25245479-8	2015	This review focuses on the basic steps of Fe-S cluster biogenesis, drawing attention to recent advances achieved on the identification of molecular features that guide selection of specific subsets of nascent Fe-S recipients by the cochaperone HSC20.	Iron	42-46	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	244-249
25245479-8	2015	This review focuses on the basic steps of Fe-S cluster biogenesis, drawing attention to recent advances achieved on the identification of molecular features that guide selection of specific subsets of nascent Fe-S recipients by the cochaperone HSC20.	Iron	209-213	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	244-249
25858146-1	2015	Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-8
25858146-3	2015	Prostatic hepcidin functions as an autocrine hormone, decreasing cell surface ferroportin, an iron exporter, increasing intracellular iron retention, and promoting prostate cancer cell survival.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	10-18
25858146-3	2015	Prostatic hepcidin functions as an autocrine hormone, decreasing cell surface ferroportin, an iron exporter, increasing intracellular iron retention, and promoting prostate cancer cell survival.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	10-18
25839091-1	2015	PURPOSE: The aim of this work was to study the involvement of IGFBP-3/Tf complexes in the pathology of colorectal carcinoma (CRC), quantify them, investigate their relation to iron concentration and binding to transferrin receptor (TfR) in colon tissue (non-cancer and cancer), and to assess the priority of this pathway for internalization of IGFBP-3.	Iron	176-180	insulin like growth factor binding protein 3	Homo sapiens	62-69
25839091-12	2015	IGFBP-3/Tf complexes in patients with CRC exhibit increased affinity for iron ions.	Iron	73-77	insulin like growth factor binding protein 3	Homo sapiens	0-7
25649872-10	2015	These data suggest that Zip8 and Steap2 play a major role in iron accumulation from NTBI and TBI by hippocampal neurons.	Iron	61-65	STEAP2 metalloreductase	Rattus norvegicus	33-39
25649872-13	2015	Zip8 and Steap2 are strongly expressed in the plasma membrane of both soma and processes, implying a crucial role in iron accumulation from NTBI and transferrin-bound iron (TBI) by hippocampal neurons.	Iron	117-121	STEAP2 metalloreductase	Rattus norvegicus	9-15
25649872-13	2015	Zip8 and Steap2 are strongly expressed in the plasma membrane of both soma and processes, implying a crucial role in iron accumulation from NTBI and transferrin-bound iron (TBI) by hippocampal neurons.	Iron	167-171	STEAP2 metalloreductase	Rattus norvegicus	9-15
25897079-0	2015	The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Iron	132-136	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	23-52
25897079-0	2015	The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Iron	132-136	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	67-70
25897079-0	2015	The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Iron	132-136	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	77-101
25897079-2	2015	Although iron-sulfur (Fe-S) cluster binding by XPD is required for activity, the process mediating Fe-S cluster assembly remains poorly understood.	Iron	22-26	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	47-50
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-41	cytosolic iron-sulfur assembly component 2B	Homo sapiens	113-119
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-41	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	202-205
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-39	cytosolic iron-sulfur assembly component 2B	Homo sapiens	113-119
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-39	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	202-205
25897079-4	2015	Here, we use XPD as a prototypical Fe-S protein to further characterize how Fe-S assembly is facilitated by the CIA targeting complex.	Iron	35-39	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	13-16
25897079-4	2015	Here, we use XPD as a prototypical Fe-S protein to further characterize how Fe-S assembly is facilitated by the CIA targeting complex.	Iron	76-80	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	13-16
25897079-5	2015	Multiple lines of evidence indicate that this process occurs in a stepwise fashion in which XPD acquires a Fe-S cluster from the CIA targeting complex before assembling into TFIIH.	Iron	107-111	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	92-95
26016555-0	2015	Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions.	Iron	16-20	lactotransferrin	Bos taurus	27-38
21360085-6	2012	Following the iron-complexing strategy of the ferrous iron which is present in the active site of Plasmodium DOHH, a series of iron chelating compounds was tested.	Iron	14-18	deoxyhypusine hydroxylase/monooxygenase	Mus musculus	109-113
21360085-6	2012	Following the iron-complexing strategy of the ferrous iron which is present in the active site of Plasmodium DOHH, a series of iron chelating compounds was tested.	Iron	54-58	deoxyhypusine hydroxylase/monooxygenase	Mus musculus	109-113
21360085-6	2012	Following the iron-complexing strategy of the ferrous iron which is present in the active site of Plasmodium DOHH, a series of iron chelating compounds was tested.	Iron	54-58	deoxyhypusine hydroxylase/monooxygenase	Mus musculus	109-113
22068728-0	2012	Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	48-76
22068728-0	2012	Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	78-82
22068728-0	2012	Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA.	Iron	0-4	solute carrier family 31 member 1	Homo sapiens	94-114
22068728-0	2012	Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA.	Iron	0-4	solute carrier family 31 member 1	Homo sapiens	116-121
22068728-6	2012	Both shRNA-DMT1 and shRNA-hCTR1 cells had lower apical Fe uptake (a decrease of 51% and 41%, respectively), Cu uptake (a decrease of 25.8% and 38.5%, respectively), and Zn content (a decrease of 23.1% and 22.7%, respectively) compared to control cells.	Iron	55-57	solute carrier family 11 member 2	Homo sapiens	11-15
22068728-6	2012	Both shRNA-DMT1 and shRNA-hCTR1 cells had lower apical Fe uptake (a decrease of 51% and 41%, respectively), Cu uptake (a decrease of 25.8% and 38.5%, respectively), and Zn content (a decrease of 23.1% and 22.7%, respectively) compared to control cells.	Iron	55-57	solute carrier family 31 member 1	Homo sapiens	26-31
22068728-7	2012	These results confirm that DMT1 is involved in active transport of Fe, Cu, and Zn although Zn showed a different relative capacity.	Iron	67-69	solute carrier family 11 member 2	Homo sapiens	27-31
22180422-3	2012	Here we examine the role of maternal and fetal Hfe, its downstream signaling molecule, hepcidin and dietary iron in the regulation of placental iron transfer.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	87-95
22323359-7	2012	Our findings suggest that TF, TFR2 and TMPRSS6 polymorphisms are significantly associated with decreased iron status, but only variants in TMPRSS6 are genetic risk factors for iron deficiency and IDA.	Iron	105-109	transferrin receptor 2	Homo sapiens	30-34
23087549-1	2012	Resistance to recombinant erythropoietin (rEPO) in hemodialysis patients may be due to inadequate iron recruitment and defect in iron use.	Iron	98-102	erythropoietin	Rattus norvegicus	42-46
23087549-1	2012	Resistance to recombinant erythropoietin (rEPO) in hemodialysis patients may be due to inadequate iron recruitment and defect in iron use.	Iron	129-133	erythropoietin	Rattus norvegicus	42-46
22278021-6	2012	IL-10-mediated protection and subsequent renal repair were dependent on the presence of iron and lipocalin-2, since the administration of a neutralizing antibody for lipocalin-2 or administration of IL-10 macrophages pretreated with the iron chelating agent deferoxamine abrogated IL-10-mediated protective effects.	Iron	88-92	interleukin 10	Rattus norvegicus	0-5
22278021-6	2012	IL-10-mediated protection and subsequent renal repair were dependent on the presence of iron and lipocalin-2, since the administration of a neutralizing antibody for lipocalin-2 or administration of IL-10 macrophages pretreated with the iron chelating agent deferoxamine abrogated IL-10-mediated protective effects.	Iron	88-92	interleukin 10	Rattus norvegicus	199-204
22278021-6	2012	IL-10-mediated protection and subsequent renal repair were dependent on the presence of iron and lipocalin-2, since the administration of a neutralizing antibody for lipocalin-2 or administration of IL-10 macrophages pretreated with the iron chelating agent deferoxamine abrogated IL-10-mediated protective effects.	Iron	88-92	interleukin 10	Rattus norvegicus	199-204
22278021-6	2012	IL-10-mediated protection and subsequent renal repair were dependent on the presence of iron and lipocalin-2, since the administration of a neutralizing antibody for lipocalin-2 or administration of IL-10 macrophages pretreated with the iron chelating agent deferoxamine abrogated IL-10-mediated protective effects.	Iron	237-241	interleukin 10	Rattus norvegicus	0-5
22543903-4	2012	demonstrate that macrophages made to overexpress anti-inflammatory interleukin-10 protect rats with AKI through iron-mediated upregulation of lipocalin-2 and its receptors, eliciting both anti-inflammatory and proliferative responses.	Iron	112-116	interleukin 10	Rattus norvegicus	67-81
22365732-2	2012	Animal studies have shown that the expression of the main iron regulator hepcidin is significantly suppressed during pregnancy, but the factors associated with hepcidin suppression remain unknown.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	73-81
22365732-7	2012	Our findings suggest that hepcidin expression is controlled by body iron stores where soluble HJV and EPO may act as suppressors of hepcidin.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	26-34
22367199-11	2012	Yeast Jjj3, a functional ortholog of human Dph4 also shows a similar iron-binding property, indicating the conserved nature of iron sequestration across species.	Iron	127-131	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	43-47
22222553-1	2012	BACKGROUND: Hepcidin is a potential biomarker for anemia of chronic diseases and disorders of iron metabolism.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	12-20
22394099-0	2012	Absorption band III kinetics probe the picosecond heme iron motion triggered by nitric oxide binding to hemoglobin and myoglobin.	Iron	55-59	myoglobin	Homo sapiens	119-128
22394099-1	2012	To study the ultrafast movement of the heme iron induced by nitric oxide (NO) binding to hemoglobin (Hb) and myoglobin (Mb), we probed the picosecond spectral evolution of absorption band III (~760 nm) and vibrational modes (iron-histidine stretching, nu(4) and nu(7) in-plane modes) in time-resolved resonance Raman spectra.	Iron	44-48	myoglobin	Homo sapiens	109-118
22394099-1	2012	To study the ultrafast movement of the heme iron induced by nitric oxide (NO) binding to hemoglobin (Hb) and myoglobin (Mb), we probed the picosecond spectral evolution of absorption band III (~760 nm) and vibrational modes (iron-histidine stretching, nu(4) and nu(7) in-plane modes) in time-resolved resonance Raman spectra.	Iron	44-48	myoglobin	Homo sapiens	120-122
22385471-2	2012	Major developments in the field of genetics and the discovery of hepcidin as a central regulator of iron homeostasis have greatly increased our understanding of the pathophysiology of iron overload syndromes.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	65-73
22385471-2	2012	Major developments in the field of genetics and the discovery of hepcidin as a central regulator of iron homeostasis have greatly increased our understanding of the pathophysiology of iron overload syndromes.	Iron	184-188	hepcidin antimicrobial peptide	Homo sapiens	65-73
22631035-4	2012	Preclinical studies suggest that Jak inhibitors, hepcidin agonists, and exogenous transferrin may help to restore normal erythropoiesis and iron metabolism and reduce splenomegaly; however, further research is needed.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	49-57
22631036-2	2012	Current models for iron metabolism in patients with beta (beta)-thalassemia intermedia (TI) suggest that suppression of serum hepcidin results in increased iron absorption and release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	126-134
22631036-2	2012	Current models for iron metabolism in patients with beta (beta)-thalassemia intermedia (TI) suggest that suppression of serum hepcidin results in increased iron absorption and release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	126-134
22631036-2	2012	Current models for iron metabolism in patients with beta (beta)-thalassemia intermedia (TI) suggest that suppression of serum hepcidin results in increased iron absorption and release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	126-134
22631036-2	2012	Current models for iron metabolism in patients with beta (beta)-thalassemia intermedia (TI) suggest that suppression of serum hepcidin results in increased iron absorption and release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	126-134
22631036-2	2012	Current models for iron metabolism in patients with beta (beta)-thalassemia intermedia (TI) suggest that suppression of serum hepcidin results in increased iron absorption and release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	126-134
25963357-1	2015	BACKGROUND: Hepcidin, as a regulator of body iron stores, has been recently discovered to play a critical role in the pathogenesis of anemia of chronic disease.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	12-20
22170436-0	2012	Ferroportin 1 and hephaestin expression in BeWo cell line with different iron treatment.	Iron	73-77	solute carrier family 40 member 1	Homo sapiens	0-13
22170436-3	2012	Ferroportin 1 (FPN1) and hephaestin (Heph) have been identified as the important molecules involved in duodenal iron export.	Iron	112-116	solute carrier family 40 member 1	Homo sapiens	0-13
22170436-3	2012	Ferroportin 1 (FPN1) and hephaestin (Heph) have been identified as the important molecules involved in duodenal iron export.	Iron	112-116	solute carrier family 40 member 1	Homo sapiens	15-19
25963357-13	2015	CONCLUSIONS: These findings suggest possible linkage between iron metabolism and hepcidin modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	81-89
22492492-1	2012	Heme oxygenase-1 (HO-1) is an inducible antioxidant enzyme that degrades heme to three products, biliverdin, carbon monoxide (CO), and iron ion.	Iron	135-139	heme oxygenase 1	Homo sapiens	0-16
25943368-4	2015	In order to determine CP"s involvement in iron accumulation in SN and PD progression, we aim to compare the ability of iron chelation treatment to reducing both SN iron levels and motor handicap in PD patients according to the level of ceruloplasmin activity.	Iron	42-46	ceruloplasmin	Homo sapiens	22-24
22492492-1	2012	Heme oxygenase-1 (HO-1) is an inducible antioxidant enzyme that degrades heme to three products, biliverdin, carbon monoxide (CO), and iron ion.	Iron	135-139	heme oxygenase 1	Homo sapiens	18-22
22343016-0	2012	Ceruloplasmin alters intracellular iron regulated proteins and pathways: ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1alpha.	Iron	35-39	ceruloplasmin	Homo sapiens	0-13
22343016-1	2012	Ceruloplasmin (Cp) is a ferroxidase important to the regulation of both systemic and intracellular iron levels.	Iron	99-103	ceruloplasmin	Homo sapiens	0-13
25943368-4	2015	In order to determine CP"s involvement in iron accumulation in SN and PD progression, we aim to compare the ability of iron chelation treatment to reducing both SN iron levels and motor handicap in PD patients according to the level of ceruloplasmin activity.	Iron	119-123	ceruloplasmin	Homo sapiens	22-24
25943368-4	2015	In order to determine CP"s involvement in iron accumulation in SN and PD progression, we aim to compare the ability of iron chelation treatment to reducing both SN iron levels and motor handicap in PD patients according to the level of ceruloplasmin activity.	Iron	119-123	ceruloplasmin	Homo sapiens	22-24
25710710-3	2015	RECENT FINDINGS: Stress erythropoiesis causes suppression of hepcidin to increase iron availability for hemoglobin synthesis.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	61-69
22475284-1	2012	The diagnostic value of hepcidin, the master regulator of iron metabolism, as an index of iron status is being intensively investigated.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	24-32
22475284-1	2012	The diagnostic value of hepcidin, the master regulator of iron metabolism, as an index of iron status is being intensively investigated.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	24-32
25710710-7	2015	Iron deficiency suppresses erythropoietin production via the IRP1-HIF2alpha axis to prevent excessive iron usage by erythropoiesis during systemic iron restriction.	Iron	102-106	endothelial PAS domain protein 1	Homo sapiens	66-75
25710710-7	2015	Iron deficiency suppresses erythropoietin production via the IRP1-HIF2alpha axis to prevent excessive iron usage by erythropoiesis during systemic iron restriction.	Iron	147-151	endothelial PAS domain protein 1	Homo sapiens	66-75
25983723-0	2015	Distinct microbial populations are tightly linked to the profile of dissolved iron in the methanic sediments of the Helgoland mud area, North Sea.	Iron	78-82	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	142-145
21685415-1	2012	Hepcidin is a known key modulator of iron homeostasis and an innate immune molecule secreted by the liver.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
22373544-4	2012	We establish the membrane ions" contributions (sodium, potassium, calcium and iron) mediated by water to the antagonism of these drugs at the 5-HT1A receptor.	Iron	78-82	5-hydroxytryptamine receptor 1A	Homo sapiens	142-157
22373544-6	2012	Our results indicate that potassium, calcium and iron play a key role for the antagonistic activity of drugs at the 5-HT1A receptor.	Iron	49-53	5-hydroxytryptamine receptor 1A	Homo sapiens	116-131
25596269-0	2015	Differences in the erythropoiesis-hepcidin-iron store axis between hemoglobin H disease and beta-thalassemia intermedia.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	34-42
22350482-1	2012	BACKGROUND: Hepcidin, a key regulator of iron homeostasis, is also a marker of acute inflammation.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	12-20
26029709-1	2015	Hereditary hemochromatosis (HH) type 3 is an autosomal recessive disorder of iron metabolism characterized by excessive iron deposition in the liver and caused by mutations in the transferrin receptor 2 (TFR2) gene.	Iron	77-81	transferrin receptor 2	Homo sapiens	180-202
26029709-1	2015	Hereditary hemochromatosis (HH) type 3 is an autosomal recessive disorder of iron metabolism characterized by excessive iron deposition in the liver and caused by mutations in the transferrin receptor 2 (TFR2) gene.	Iron	77-81	transferrin receptor 2	Homo sapiens	204-208
22304436-4	2012	This study sought to identify the molecular target in microbial cells by comparing the transcriptional profiles of key copper and iron homeostasis genes (CTR1, FRE1, FET3, CUP1, CRS5) in cells exposed to saxitoxin, excess copper, excess iron, an extracellular Cu(I) chelator, or an intracellular Cu(I) chelator.	Iron	237-241	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	154-158
21810453-12	2012	GENERAL SIGNIFICANCE: Future studies in Tsf1 as well as the other insect transferrins that bind iron are warranted because of the roles of transferrin in preventing oxidative stress, enhancing survival to infections and delivering iron to eggs for development.	Iron	96-100	serine/threonine kinase 16	Homo sapiens	40-44
21810453-12	2012	GENERAL SIGNIFICANCE: Future studies in Tsf1 as well as the other insect transferrins that bind iron are warranted because of the roles of transferrin in preventing oxidative stress, enhancing survival to infections and delivering iron to eggs for development.	Iron	231-235	serine/threonine kinase 16	Homo sapiens	40-44
26029709-9	2015	TFR2 genotyping should be considered in adult but also in pediatric cases with early-onset of iron overload.	Iron	94-98	transferrin receptor 2	Homo sapiens	0-4
25899529-6	2015	Excess beta2-M in the HK-2 cells led to a decrease in iron and an increase in hypoxia inducible factor-1alpha (HIF-1alpha), which induced EMT in the HK-2 cells.	Iron	54-58	beta-2-microglobulin	Homo sapiens	7-14
22040722-0	2012	The transfer of iron between ceruloplasmin and transferrins.	Iron	16-20	ceruloplasmin	Homo sapiens	29-42
22040722-10	2012	A direct transfer of ferric iron from ceruloplasmin to lactoferrin would prevent both the formation of potentially toxic hydroxyl radicals and the utilization of iron by pathogenic bacteria.	Iron	28-32	ceruloplasmin	Homo sapiens	38-51
25899529-8	2015	CONCLUSION: These findings demonstrate that the activity of beta2-M is mediated by the beta2-M/HFE complex, which regulates intracellular iron homeostasis and HIF-1alpha and ultimately induces EMT in HK2 cells.	Iron	138-142	beta-2-microglobulin	Homo sapiens	60-67
25995874-1	2015	The title iron(II) complex, [Fe(C16H12NO2)2], crystallizes in the ortho-rhom-bic space group Pbca with the Fe(2+) cation positioned on an inversion center.	Iron	29-31	PBCA	Homo sapiens	93-97
22085723-5	2012	Recent data uncovered an additional role of transferrin as an upstream regulator of hepcidin, a liver-derived peptide hormone that controls systemic iron traffic.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	84-92
22085723-7	2012	We further discuss the role of hepcidin as an orchestrator of systemic iron homeostasis, and the mechanisms underlying hepcidin regulation in response to various physiological cues.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	31-39
22085723-8	2012	Emphasis is given on the role of transferrin on iron-dependent hepcidin regulation.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	63-71
22085723-9	2012	MAJOR CONCLUSIONS: Transferrin exerts a crucial function in the maintenance of systemic iron homeostasis as component of a plasma iron sensing system that modulates hepcidin expression.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	165-173
25590823-3	2015	High S(-II):Fe ratio caused a more complete dissolution of ferrihydrite and a large fraction of As(V) could be released into solution.	Iron	12-14	transcription elongation factor A1	Homo sapiens	5-10
22230225-2	2012	Lactoferrin (Lf) is an iron-binding glycoprotein that is found predominantly in the milk of mammals.	Iron	23-27	lactotransferrin	Bos taurus	0-11
22230225-2	2012	Lactoferrin (Lf) is an iron-binding glycoprotein that is found predominantly in the milk of mammals.	Iron	23-27	lactotransferrin	Bos taurus	13-15
25588876-1	2015	Mutations in the TMPRSS6 gene are associated with severe iron-refractory iron deficiency anemia resulting from an overexpression of hepcidin, the key regulator of iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	132-140
25465232-1	2015	Hepatic hepcidin-25 production is stimulated by systemic inflammation, and it interferes with the body"s utilization of iron, leading to anemia.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	8-16
22717199-0	2012	Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	114-122
22717199-5	2012	Hepcidin, a small peptide hormone produced mainly by the liver, acts as the key regulator of systemic iron homeostasis.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	0-8
22717199-6	2012	Hepcidin controls movement of iron into plasma by regulating the activity of the sole known iron exporter ferroportin-1.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
22717199-6	2012	Hepcidin controls movement of iron into plasma by regulating the activity of the sole known iron exporter ferroportin-1.	Iron	30-34	solute carrier family 40 member 1	Homo sapiens	106-119
22717199-6	2012	Hepcidin controls movement of iron into plasma by regulating the activity of the sole known iron exporter ferroportin-1.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	0-8
22717199-6	2012	Hepcidin controls movement of iron into plasma by regulating the activity of the sole known iron exporter ferroportin-1.	Iron	92-96	solute carrier family 40 member 1	Homo sapiens	106-119
25699651-5	2015	In conclusion, hypermethylation of HJV promoter region could silence the gene expression and demethylating therapy might ameliorate iron-overload through HJV demethylation.	Iron	132-136	hemojuvelin BMP co-receptor	Homo sapiens	35-38
22717199-7	2012	Downregulation of the ferroportin-1 exporter results in sequestration of iron within intestinal enterocytes, hepatocytes, and iron-storing macrophages reducing iron bioavailability.	Iron	73-77	solute carrier family 40 member 1	Homo sapiens	22-35
22717199-7	2012	Downregulation of the ferroportin-1 exporter results in sequestration of iron within intestinal enterocytes, hepatocytes, and iron-storing macrophages reducing iron bioavailability.	Iron	126-130	solute carrier family 40 member 1	Homo sapiens	22-35
22717199-7	2012	Downregulation of the ferroportin-1 exporter results in sequestration of iron within intestinal enterocytes, hepatocytes, and iron-storing macrophages reducing iron bioavailability.	Iron	126-130	solute carrier family 40 member 1	Homo sapiens	22-35
22717199-8	2012	Hepcidin expression is increased by higher body iron levels and inflammation and decreased by anemia and hypoxia.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-8
22717199-9	2012	Importantly, existing data illustrate that hepcidin may play a significant role in the development of several iron-related disorders, including the anemia of chronic disease and the iron dysregulation observed in obesity.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	43-51
22717199-9	2012	Importantly, existing data illustrate that hepcidin may play a significant role in the development of several iron-related disorders, including the anemia of chronic disease and the iron dysregulation observed in obesity.	Iron	182-186	hepcidin antimicrobial peptide	Homo sapiens	43-51
25637053-0	2015	Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.	Iron	53-57	transferrin receptor 2	Homo sapiens	27-49
22038922-6	2012	Iron and BCL2-interacting mediator of cell death (BIM) protein were involved in LCN2-induced cell death sensitization, based on the studies using iron donor, chelator, siderophore, and short hairpin RNA (shRNA)-mediated knockdown of bim expression.	Iron	0-4	BCL2 like 11	Homo sapiens	50-53
22038922-6	2012	Iron and BCL2-interacting mediator of cell death (BIM) protein were involved in LCN2-induced cell death sensitization, based on the studies using iron donor, chelator, siderophore, and short hairpin RNA (shRNA)-mediated knockdown of bim expression.	Iron	0-4	BCL2 like 11	Homo sapiens	233-236
22038922-6	2012	Iron and BCL2-interacting mediator of cell death (BIM) protein were involved in LCN2-induced cell death sensitization, based on the studies using iron donor, chelator, siderophore, and short hairpin RNA (shRNA)-mediated knockdown of bim expression.	Iron	146-150	BCL2 like 11	Homo sapiens	50-53
21647550-2	2012	On the other hand, oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD) and heme oxygenase-1 (HO-1), encoded by the HMOX1 gene and heme oxygenase-2 (HO-2), encoded by the HMOX2 gene are important markers of iron-related oxidative stress and its consequences.	Iron	253-257	heme oxygenase 1	Homo sapiens	122-138
21647550-2	2012	On the other hand, oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD) and heme oxygenase-1 (HO-1), encoded by the HMOX1 gene and heme oxygenase-2 (HO-2), encoded by the HMOX2 gene are important markers of iron-related oxidative stress and its consequences.	Iron	253-257	heme oxygenase 1	Homo sapiens	140-144
25637053-2	2015	Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.	Iron	52-56	transferrin receptor 2	Homo sapiens	0-22
22331876-1	2012	Hephaestin (Heph), a membrane-bound multicopper ferroxidase (FOX) expressed in duodenal enterocytes, is required for optimal iron absorption.	Iron	125-129	hephaestin	Rattus norvegicus	0-10
25637053-2	2015	Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.	Iron	109-113	transferrin receptor 2	Homo sapiens	0-22
22331876-1	2012	Hephaestin (Heph), a membrane-bound multicopper ferroxidase (FOX) expressed in duodenal enterocytes, is required for optimal iron absorption.	Iron	125-129	hephaestin	Rattus norvegicus	0-4
25637053-3	2015	Hepatic transferrin receptor-2 participates in iron sensing and is involved in hepcidin activation, although the mechanism remains unclear.	Iron	47-51	transferrin receptor 2	Homo sapiens	8-30
25637053-8	2015	This observation links the process of transferrin receptor-2 removal from the plasma membrane to iron homeostasis.	Iron	97-101	transferrin receptor 2	Homo sapiens	38-60
25637053-11	2015	Our results indicate that membrane transferrin receptor-2, a sensor of circulating iron, is released from the cell membrane in iron deficiency.	Iron	83-87	transferrin receptor 2	Homo sapiens	35-57
25976565-0	2015	Association between hepcidin, haemoglobin level and iron status in stage 4 chronic kidney disease patients with anaemia.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	20-28
22078996-4	2012	Fe uptake is related to the expression of a Fe(2+) transporter (IRT1).	Iron	0-2	allograft inflammatory factor 1	Homo sapiens	64-68
22078996-7	2012	Under Fe deficiency an over-accumulation of H(+)-ATPase and IRT1 proteins was observed especially around the cortex cells of nodules.	Iron	6-8	allograft inflammatory factor 1	Homo sapiens	60-64
25976565-1	2015	OBJECTIVE: To explore the probable association of serum hepcidin and haemoglobin levels with iron and inflammation statuses in patients of chronic kidney disease stage 4 with anaemia.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	56-64
22236554-0	2012	Synthesis of iron nanoparticles from hemoglobin and myoglobin.	Iron	13-17	myoglobin	Homo sapiens	52-61
25976565-7	2015	There were significant correlations between hepcidin with iron status, nutritional and inflammatory markers such as ferritin, Total iron binding capacity, albumin and interleukin 6 (p&lt;0.05 each).	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	44-52
22236554-1	2012	Stable iron nanoparticles have been synthesized from naturally occurring and abundant Fe-containing bio-precursors, namely hemoglobin and myoglobin.	Iron	7-11	myoglobin	Homo sapiens	138-147
22236554-1	2012	Stable iron nanoparticles have been synthesized from naturally occurring and abundant Fe-containing bio-precursors, namely hemoglobin and myoglobin.	Iron	86-88	myoglobin	Homo sapiens	138-147
25976565-7	2015	There were significant correlations between hepcidin with iron status, nutritional and inflammatory markers such as ferritin, Total iron binding capacity, albumin and interleukin 6 (p&lt;0.05 each).	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	44-52
25976565-8	2015	CONCLUSIONS: Hepcidin had negative correlation with haemoglobin level in stage 4 chronic kidney disease patients with adequate iron stores, which could be effective in the development of anaemia in such patients.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	13-21
25575693-6	2015	We found that compared with 6-month-old APP/PS1 mice and the 12-month-old C57 mice, the 12-month-old APP/PS1 mice had increased iron load in the frontal cortex.	Iron	128-132	presenilin 1	Mus musculus	105-108
22239740-2	2012	In this work, a series of Fe-zeolite catalysts (Fe-MOR, Fe-ZSM-5, and Fe-BEA) was prepared by ion exchange method, and their catalytic activity with or without propene for selective catalytic reduction of NO(x) with ammonia (NH(3)-SCR) was investigated.	Iron	26-28	opioid receptor mu 1	Homo sapiens	51-54
22239740-2	2012	In this work, a series of Fe-zeolite catalysts (Fe-MOR, Fe-ZSM-5, and Fe-BEA) was prepared by ion exchange method, and their catalytic activity with or without propene for selective catalytic reduction of NO(x) with ammonia (NH(3)-SCR) was investigated.	Iron	48-50	opioid receptor mu 1	Homo sapiens	51-54
25666510-0	2015	Expression of human Hemojuvelin (HJV) is tightly regulated by two upstream open reading frames in HJV mRNA that respond to iron overload in hepatic cells.	Iron	123-127	hemojuvelin BMP co-receptor	Homo sapiens	20-31
22308404-0	2012	Strand swapping regulates the iron-sulfur cluster in the diabetes drug target mitoNEET.	Iron	30-34	CDGSH iron sulfur domain 1	Homo sapiens	78-86
25666510-0	2015	Expression of human Hemojuvelin (HJV) is tightly regulated by two upstream open reading frames in HJV mRNA that respond to iron overload in hepatic cells.	Iron	123-127	hemojuvelin BMP co-receptor	Homo sapiens	33-36
22095982-1	2012	OBJECTIVE: We recently reported that lowering of macrophage free intracellular iron increases expression of cholesterol efflux transporters ABCA1 and ABCG1 by reducing generation of reactive oxygen species.	Iron	79-83	ATP binding cassette subfamily G member 1	Mus musculus	150-155
25666510-0	2015	Expression of human Hemojuvelin (HJV) is tightly regulated by two upstream open reading frames in HJV mRNA that respond to iron overload in hepatic cells.	Iron	123-127	hemojuvelin BMP co-receptor	Homo sapiens	98-101
25666510-1	2015	The gene encoding human hemojuvelin (HJV) is one of the genes that, when mutated, can cause juvenile hemochromatosis, an early-onset inherited disorder associated with iron overload.	Iron	168-172	hemojuvelin BMP co-receptor	Homo sapiens	24-35
22101253-6	2012	We concluded that both FDX1 and FDX2 were important in iron-sulfur cluster biogenesis.	Iron	55-59	ferredoxin 2	Homo sapiens	32-36
25666510-1	2015	The gene encoding human hemojuvelin (HJV) is one of the genes that, when mutated, can cause juvenile hemochromatosis, an early-onset inherited disorder associated with iron overload.	Iron	168-172	hemojuvelin BMP co-receptor	Homo sapiens	37-40
22101253-9	2012	Our studies suggest that interference with any of the three related genes, FDX1, FDX2 or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis.	Iron	104-108	ferredoxin 2	Homo sapiens	81-85
25666510-10	2015	These results support a tight HJV translational regulation involved in iron homeostasis.	Iron	71-75	hemojuvelin BMP co-receptor	Homo sapiens	30-33
22101253-9	2012	Our studies suggest that interference with any of the three related genes, FDX1, FDX2 or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis.	Iron	187-191	ferredoxin 2	Homo sapiens	81-85
26182354-0	2015	Hepcidin: regulation of the master iron regulator.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
26182354-4	2015	Hepcidin binds to the only known iron export protein, ferroportin (FPN), inducing its internalization and degradation, thus limiting the amount of iron released into the blood.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
26182354-4	2015	Hepcidin binds to the only known iron export protein, ferroportin (FPN), inducing its internalization and degradation, thus limiting the amount of iron released into the blood.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	0-8
26182354-5	2015	The major factors that are implicated in hepcidin regulation include iron stores, hypoxia, inflammation and erythropoiesis.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	41-49
25811852-0	2015	Correction: The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	28-36
25885228-1	2015	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells.	Iron	117-121	heme oxygenase 1	Homo sapiens	0-16
25885228-1	2015	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells.	Iron	117-121	heme oxygenase 1	Homo sapiens	18-22
25664448-2	2015	Further reaction of 2b with MCl2 (M = Co or Fe) formed the eight-membered binuclear metallic 8-quinolylguanidinate complexes [{8-(2-CH3-C9H5N)NC(NMe2)N(SiMe3)}MCl]2 (M = Fe, 3; Co, 4).	Iron	44-46	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	145-149
25761244-1	2015	Heme oxygenase-1 (HO-1) is a 32 kDa protein which catalyzes the breakdown of heme to free iron, carbon monoxide and biliverdin.	Iron	90-94	heme oxygenase 1	Homo sapiens	0-16
25213357-1	2015	Mitochondrial ferritin (FtMt) has a significant effect on the regulation of cytosolic and mitochondrial iron levels.	Iron	104-108	ferritin mitochondrial	Homo sapiens	0-22
25213357-1	2015	Mitochondrial ferritin (FtMt) has a significant effect on the regulation of cytosolic and mitochondrial iron levels.	Iron	104-108	ferritin mitochondrial	Homo sapiens	24-28
25213357-2	2015	However, because of the deficiency of iron regulatory elements (IRE) in FtMt"s gene sequence, the exact function of FtMt remains unclear.	Iron	38-42	ferritin mitochondrial	Homo sapiens	72-76
25213357-9	2015	As expected, FtMt overexpression disturbed the iron homeostasis of tumor cells and significantly downregulated the expression of proliferating cell nuclear antigen.	Iron	47-51	ferritin mitochondrial	Homo sapiens	13-17
25564095-7	2015	Although TrxR activity showed an increase in TM patients due to an elevated iron overload, both TrxR activity and Trx1 level were lower in the patient groups compared with the cases in the control group.	Iron	76-80	peroxiredoxin 5	Homo sapiens	9-13
25794933-0	2015	The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis.	Iron	90-94	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	30-37
25794933-4	2015	Knockout of bHLH104 in Arabidopsis thaliana greatly reduced tolerance to Fe deficiency, whereas overexpression of bHLH104 had the opposite effect and led to accumulation of excess Fe in soil-grown conditions.	Iron	73-75	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	12-19
25794933-6	2015	Further investigation showed that bHLH104 interacted with another IVc subgroup bHLH protein, IAA-LEUCINE RESISTANT3 (ILR3), which also plays an important role in Fe homeostasis.	Iron	162-164	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	34-41
25036750-9	2015	HB9 expression in 500 nM iron-treated hESCs is approximately twofold higher than the control.	Iron	25-29	motor neuron and pancreas homeobox 1	Homo sapiens	0-3
25729473-6	2015	These include impaired iron export from hepatocytes and mesenchymal Kupffer cells as a consequence of imbalances in the concentrations of iron regulatory factors, such as hepcidin, cytokines, copper or other dietary factors.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	171-179
25685985-3	2015	This protein captures huge amounts of iron ions inside the apoferritin shell and isolates them from the environment.	Iron	38-42	ferritin heavy chain 1	Homo sapiens	59-70
25556595-1	2015	The glutathione-coordinated [2Fe-2S] cluster is demonstrated to be a viable and likely substrate for physiological iron-sulfur cluster transport by Atm1p, a mitochondrial ABC export protein.	Iron	115-119	ATP binding cassette subfamily B member 7	Homo sapiens	148-153
25500022-6	2015	The NF-kappaB inhibitor [5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide (TPCA-1), which inhibits IKKbeta, the kinase of IkappaBalpha (inhibitory protein of NF-kappaB), was used to prevent iron overload-stimulated NF-kappaB changes in ESCs.	Iron	194-198	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	103-110
25500022-13	2015	CONCLUSION(S): Iron overload activates IKKbeta in ESCs, stimulating the NF-kappaB pathway and increasing ICAM-1 expression and sICAM-1 secretion.	Iron	15-19	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	39-46
24687402-1	2015	BACKGROUND: Hepcidin-25 is an iron regulator which reduces iron absorption and promotes sequestration in the reticulo-endothelial system.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	12-20
24687402-1	2015	BACKGROUND: Hepcidin-25 is an iron regulator which reduces iron absorption and promotes sequestration in the reticulo-endothelial system.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	12-20
24687402-7	2015	Log10 hepcidin-25 was an independent predictor of haemoglobin increment 6 weeks following iron infusion [coefficient -0.84 (-1.38 to -0.31) p = 0.002].	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	6-14
24687402-9	2015	CONCLUSIONS: Hepcidin is an iron sensor marker which predicts the magnitude of haemoglobin increment following protocolised intravenous iron infusion.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	13-21
24687402-9	2015	CONCLUSIONS: Hepcidin is an iron sensor marker which predicts the magnitude of haemoglobin increment following protocolised intravenous iron infusion.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	13-21
24706563-1	2015	PURPOSE: Fitting the measured decay signal to the first moment in the presence of noncentral chi noise (M(1) NCM) can correctly address the effect of noise on the effective transverse relaxation rate (R2*) relaxometry of iron loaded liver.	Iron	221-225	CWC22 spliceosome associated protein homolog	Homo sapiens	109-112
21804084-2	2012	Hepcidin, a peptide hormone that regulates iron homeostasis, is a potential biomarker of AKI following CPB.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
22286308-6	2012	Amyloid precursor protein (APP) ferroxidase activity couples with surface ferroportin to export iron, but its activity is inhibited in Alzheimer"s disease, thereby causing neuronal iron accumulation.	Iron	96-100	amyloid beta (A4) precursor protein	Mus musculus	0-25
22286308-6	2012	Amyloid precursor protein (APP) ferroxidase activity couples with surface ferroportin to export iron, but its activity is inhibited in Alzheimer"s disease, thereby causing neuronal iron accumulation.	Iron	181-185	amyloid beta (A4) precursor protein	Mus musculus	0-25
25284145-6	2015	Furthermore, PNPLA3 GG genotype was associated with iron depositions (OR 2.8, 95%CI: 1.2-6.4, P = 0.014) and lobular inflammation (OR 2.2, 95%CI: 1.1-4.5, P = 0.032), but not with advanced fibrosis (OR 1.1, 95%CI: 0.7-1.8, P = 0.566).	Iron	52-56	patatin like phospholipase domain containing 3	Homo sapiens	13-19
22128145-0	2012	Deletion of HIF-2alpha in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice.	Iron	75-79	endothelial PAS domain protein 1	Mus musculus	12-22
25284145-9	2015	CONCLUSIONS: In this cohort of biopsied CHB patients, PNPLA3 was independently associated with steatosis, steatohepatitis, lobular inflammation and iron depositions, but not with advanced fibrosis, HCC development or all-cause mortality.	Iron	148-152	patatin like phospholipase domain containing 3	Homo sapiens	54-60
25306858-9	2015	Moreover, the translational control of HIF2alpha mRNA in kidney by IRP1 coordinates erythropoietin synthesis with iron and oxygen supply.	Iron	114-118	endothelial PAS domain protein 1	Homo sapiens	39-48
25306858-10	2015	Besides IRPs, body iron absorption is negatively regulated by hepcidin.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	62-70
22347348-8	2012	In the severe COPD patients, hepcidin level increased with the increase in serum iron (P=0.000), hct (P=0.009), ferritin levels (P=0.012), and arterial oxygen saturation (SaO(2), P=0.000).	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	29-37
25385426-7	2015	In terms of responses to iron HIF2alpha is of major importance in key tissues such as the intestine where several iron transporters (Ferroportin, Dcytb) contain HREs within their promoters which bind HIF2alpha.	Iron	25-29	endothelial PAS domain protein 1	Homo sapiens	30-39
25385426-7	2015	In terms of responses to iron HIF2alpha is of major importance in key tissues such as the intestine where several iron transporters (Ferroportin, Dcytb) contain HREs within their promoters which bind HIF2alpha.	Iron	25-29	endothelial PAS domain protein 1	Homo sapiens	200-209
22089387-5	2012	The second is a heterooctameric alpha(4)beta(4)-type ProDH, which uses flavin adenine dinucleotide, flavin mononucleotide, adenosine triphosphate, and Fe as cofactors and creates a new electron transfer pathway.	Iron	151-153	proline dehydrogenase 1	Homo sapiens	53-58
25385426-8	2015	Furthermore the recent discovery that HIF2alpha contains a 5" iron responsive element (IRE) has underlined the importance of HIF2alpha as a major player in iron metabolism.	Iron	62-66	endothelial PAS domain protein 1	Homo sapiens	38-47
25385426-8	2015	Furthermore the recent discovery that HIF2alpha contains a 5" iron responsive element (IRE) has underlined the importance of HIF2alpha as a major player in iron metabolism.	Iron	62-66	endothelial PAS domain protein 1	Homo sapiens	125-134
23019066-5	2012	Plastically expressed genes included both genes regulated directly by copper-binding transcription factors Mac1 and Ace1 and genes indirectly responding to the downstream metabolic consequences of the copper gradient, particularly genes involved in copper, iron, and sulfur homeostasis.	Iron	257-261	Cup2p	Saccharomyces cerevisiae S288C	116-120
25385426-8	2015	Furthermore the recent discovery that HIF2alpha contains a 5" iron responsive element (IRE) has underlined the importance of HIF2alpha as a major player in iron metabolism.	Iron	156-160	endothelial PAS domain protein 1	Homo sapiens	38-47
25385426-8	2015	Furthermore the recent discovery that HIF2alpha contains a 5" iron responsive element (IRE) has underlined the importance of HIF2alpha as a major player in iron metabolism.	Iron	156-160	endothelial PAS domain protein 1	Homo sapiens	125-134
25168455-1	2015	Aceruloplasminemia is characterized by progressive neurodegeneration with brain iron accumulation due to the complete lack of ceruloplasmin ferroxidase activity caused by mutations in the ceruloplasmin gene.	Iron	80-84	ceruloplasmin	Homo sapiens	1-14
23193472-3	2012	In addition to the usual iron parameters, the iron status of erythrocytes can be determined by measuring reticulocyte hemoglobin (RET-He).	Iron	46-50	ret proto-oncogene	Homo sapiens	130-133
25168455-4	2015	The lack of ceruloplasmin may primarily damage astrocytes in the aceruloplasminemic brains as a result of lipid peroxidation due to massive iron deposition.	Iron	140-144	ceruloplasmin	Homo sapiens	12-25
25168455-7	2015	In cases with aceruloplasminemia, neurons take up the iron from alternative sources of non-transferrin-bound iron, because astrocytes without GPI-linked ceruloplasmin cannot transport iron to transferrin.	Iron	54-58	ceruloplasmin	Homo sapiens	15-28
22112169-3	2012	The rate of in vitro incorporation of iron (Fe) into Ft was tested by supplementing the reaction medium with physiological Fe chelators.	Iron	38-42	ferritin-1, chloroplastic	Glycine max	53-55
25168455-7	2015	In cases with aceruloplasminemia, neurons take up the iron from alternative sources of non-transferrin-bound iron, because astrocytes without GPI-linked ceruloplasmin cannot transport iron to transferrin.	Iron	109-113	ceruloplasmin	Homo sapiens	15-28
22112169-3	2012	The rate of in vitro incorporation of iron (Fe) into Ft was tested by supplementing the reaction medium with physiological Fe chelators.	Iron	44-46	ferritin-1, chloroplastic	Glycine max	53-55
22112169-6	2012	Moreover, a substantial decrease in the Trp-dependent fluorescence of the Ft protein was determined during Fe uptake from Fe-citrate, as compared with the control.	Iron	107-109	ferritin-1, chloroplastic	Glycine max	74-76
25168455-7	2015	In cases with aceruloplasminemia, neurons take up the iron from alternative sources of non-transferrin-bound iron, because astrocytes without GPI-linked ceruloplasmin cannot transport iron to transferrin.	Iron	109-113	ceruloplasmin	Homo sapiens	15-28
22112169-7	2012	On the other hand, Ft addition to homogenates from soybean embryonic axes reduced endogenously generated ascorbyl radical, according to its capacity for Fe uptake.	Iron	153-155	ferritin-1, chloroplastic	Glycine max	19-21
25467637-8	2015	These data suggest that decreased Ndfip1 expression might contribute to the pathogenesis of 6-OHDA-induced iron accumulation and Ndfip1 could attenuate 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.	Iron	107-111	solute carrier family 11 member 2	Homo sapiens	219-223
22112169-8	2012	The data presented here suggest that Ft could be involved in the generation of free radicals, such as hydroxyl radical, by Fe-catalyzed reactions.	Iron	123-125	ferritin-1, chloroplastic	Glycine max	37-39
22112169-10	2012	However, Ft could also prevent cellular damage by the uptake of catalytically active Fe.	Iron	85-87	ferritin-1, chloroplastic	Glycine max	9-11
25467637-8	2015	These data suggest that decreased Ndfip1 expression might contribute to the pathogenesis of 6-OHDA-induced iron accumulation and Ndfip1 could attenuate 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.	Iron	167-171	solute carrier family 11 member 2	Homo sapiens	219-223
25205158-5	2015	Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
22441209-4	2012	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	73-81
22441209-4	2012	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	73-81
25205158-10	2015	The hepcidin-FPN axis is the principal regulator of extracellular iron homeostasis in health and disease.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	4-12
22449994-9	2012	Here we report that morphological differentiation and metabolism of the iron-containing pigment in ameloblasts are independently regulated during amelogenesis by means of ectopic SP6 expression.	Iron	72-76	Sp6 transcription factor	Rattus norvegicus	179-182
25205158-14	2015	In this review, we will summarize the role of hepcidin in iron homeostasis and its contribution to the pathophysiology of inflammation and iron disorders.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	46-54
25433245-6	2015	hLF-hinge-CH2-CH3 was significantly expressed in CHO cells (~100mg/l culture), was readily purified, and exhibited 98.3% of the non-fused rhLF iron-binding activity.	Iron	143-147	HLF transcription factor, PAR bZIP family member	Homo sapiens	0-3
22035068-1	2012	Ceruloplasmin (Cp) is a ferroxidase involved in iron metabolism by converting Fe(2+) to Fe(3+), and by regulating cellular iron efflux.	Iron	48-52	ceruloplasmin	Mus musculus	0-13
22035068-1	2012	Ceruloplasmin (Cp) is a ferroxidase involved in iron metabolism by converting Fe(2+) to Fe(3+), and by regulating cellular iron efflux.	Iron	48-52	ceruloplasmin	Mus musculus	24-35
22035068-1	2012	Ceruloplasmin (Cp) is a ferroxidase involved in iron metabolism by converting Fe(2+) to Fe(3+), and by regulating cellular iron efflux.	Iron	123-127	ceruloplasmin	Mus musculus	0-13
22035068-1	2012	Ceruloplasmin (Cp) is a ferroxidase involved in iron metabolism by converting Fe(2+) to Fe(3+), and by regulating cellular iron efflux.	Iron	123-127	ceruloplasmin	Mus musculus	24-35
22035068-2	2012	In the ceruloplasmin knockout (CpKO) mouse, the deregulation of iron metabolism results in moderate liver and spleen hemosiderosis, but the impact of Cp deficiency on brain neurochemistry and behavior in this animal model is unknown.	Iron	64-68	ceruloplasmin	Mus musculus	7-20
25435467-1	2015	A discotic liquid crystal (DLC), HBC-C12, coating was successfully applied to improve the corrosion resistance of an iron surface.	Iron	117-121	keratin 88, pseudogene	Homo sapiens	33-36
22113871-0	2012	Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	9-17
22113871-8	2012	Maternal serum hepcidin and maternal/neonatal Fe status may play a role in placental uptake of dietary heme and nonheme Fe.	Iron	120-122	hepcidin antimicrobial peptide	Homo sapiens	15-23
25378496-13	2015	PK1 interacts with both ferritin and apoferritin, suppresses apoferritin"s ability to sequester free iron ions, and maintains the intracellular labile iron pool (LIP), and thus the availability of free iron is increased within cells.	Iron	101-105	ferritin heavy chain 1	Homo sapiens	61-72
22121954-0	2012	Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx.	Iron	123-127	solute carrier family 11 member 2	Homo sapiens	14-42
22121954-1	2012	The divalent metal transporter 1 (DMT1) is the best characterized Fe2+ transporter involved in cellular iron uptake in mammals.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	4-32
22121954-1	2012	The divalent metal transporter 1 (DMT1) is the best characterized Fe2+ transporter involved in cellular iron uptake in mammals.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	34-38
22121954-3	2012	Despite the general importance of DMT1 in controlling iron homeostasis, the distribution and the role of the transporter in the CNS is still controversial.	Iron	54-58	solute carrier family 11 member 2	Homo sapiens	34-38
22121954-5	2012	We found that the main isoform endogenously expressed is DMT1-1B/IRE+, which shows cytoplasmic distribution, colocalization with late endosome/lysosome markers and iron regulation, as expected from the presence of an iron responsive element.	Iron	164-168	solute carrier family 11 member 2	Homo sapiens	57-61
22121954-5	2012	We found that the main isoform endogenously expressed is DMT1-1B/IRE+, which shows cytoplasmic distribution, colocalization with late endosome/lysosome markers and iron regulation, as expected from the presence of an iron responsive element.	Iron	217-221	solute carrier family 11 member 2	Homo sapiens	57-61
25277871-1	2015	BACKGROUND/AIMS: Innately low hepcidin levels lead to iron overload in HFE-associated hereditary haemochromatosis.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	30-38
22121954-7	2012	Overall, our results argue against a physiological role of the endogenous DMT1 in neuronal iron uptake but do not exclude that, under pathological conditions, the expression of other DMT1 isoforms might contribute to iron overload.	Iron	217-221	solute carrier family 11 member 2	Homo sapiens	183-187
25277871-3	2015	RESULTS: As the genotypic risk for iron overload increased, transferrin saturation and serum NTBI levels increased while serum hepcidin levels decreased.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	127-135
22166418-1	2012	The anti-Parkinson iron chelator brain selective monoamine oxidase (MAO) AB inhibitor M30 [5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline] was shown to possess neuroprotective activities in vitro and in vivo, against several insults applicable to several neurodegenerative diseases, such as Alzheimer"s disease, Parkinson"s disease (PD) and ALS.	Iron	19-23	olfactory receptor family 10 subfamily N member 1	Mus musculus	86-89
25277871-7	2015	CONCLUSIONS: In summary, this study has shown that while serum ferritin and HFE status are the most important determinants of hepcidin levels, factors such age, gender, BMI, transferrin saturation and NTBI all interact closely in the matrix of homeostatic iron balance.	Iron	256-260	hepcidin antimicrobial peptide	Homo sapiens	126-134
25923089-1	2015	BACKGROUND: Hepcidin is a master regulator of iron metabolism that inhibits the transport of iron out of enterocytes and macrophages.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	12-20
23284832-3	2012	The proteins selected as carrier were Apotransferrin and Lactoferrin, since the receptors for these two proteins are known to be over expressed on cancer cells due to their iron transport capacity.	Iron	173-177	lactotransferrin	Rattus norvegicus	57-68
25923089-1	2015	BACKGROUND: Hepcidin is a master regulator of iron metabolism that inhibits the transport of iron out of enterocytes and macrophages.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	12-20
23110054-5	2012	Human hepcidin, a 25 amino acid peptide mainly produced by hepatocytes, is a key regulator of iron metabolism.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	6-14
25427903-10	2015	For instance, depending on the level, H2O2 may both strongly suppress and induce the expression of hepcidin that could partly explain the anemia and iron overload observed in these patients.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	99-107
23028699-1	2012	The human cysteine dioxygenase 1 (CDO1) gene is a non-heme structured, iron-containing metalloenzyme involved in the conversion of cysteine to cysteine sulfinate, and plays a key role in taurine biosynthesis.	Iron	71-75	cysteine dioxygenase type 1	Homo sapiens	10-32
23028699-1	2012	The human cysteine dioxygenase 1 (CDO1) gene is a non-heme structured, iron-containing metalloenzyme involved in the conversion of cysteine to cysteine sulfinate, and plays a key role in taurine biosynthesis.	Iron	71-75	cysteine dioxygenase type 1	Homo sapiens	34-38
25304512-11	2015	Strain GT1 grew acetogenetically with Fe(0) as the sole electron donor and enhanced iron corrosion, which is the first demonstration of MIC mediated by a pure culture of an acetogen.	Iron	38-43	beta-1,4-galactosyltransferase 1	Homo sapiens	7-10
22911836-4	2012	Our metabolite analysis revealed that Cir1 influences the glycolytic pathway, ergosterol biosynthesis and inositol metabolism, which require numerous iron-dependent enzymes and play important roles in pathogenesis and antifungal sensitivity of the fungus.	Iron	150-154	corepressor interacting with RBPJ, CIR1	Homo sapiens	38-42
22911836-5	2012	Moreover, we demonstrated that increased cellular iron content and altered gene expression in the cir1 mutant contributed to metabolite changes.	Iron	50-54	corepressor interacting with RBPJ, CIR1	Homo sapiens	98-102
25304512-11	2015	Strain GT1 grew acetogenetically with Fe(0) as the sole electron donor and enhanced iron corrosion, which is the first demonstration of MIC mediated by a pure culture of an acetogen.	Iron	84-88	beta-1,4-galactosyltransferase 1	Homo sapiens	7-10
22860081-13	2012	CONCLUSIONS/SIGNIFICANCE: Our study highlights the subcellular localization of various heme- and iron-related proteins during early steps of EP, thereby suggesting a model for heme catabolism occurring outside the phagosome, with heme likely being transported into the cytosol through HRG1.	Iron	97-101	solute carrier family 48 member 1	Homo sapiens	285-289
25744452-1	2015	Heme oxygenase-1 (HO-1) catabolizes the degradation of heme into bilirubin, carbon monoxide, and iron ions.	Iron	97-101	heme oxygenase 1	Homo sapiens	0-16
22792339-15	2012	Thus, estrogen is involved in hepcidin expression via a GPR30-BMP6-dependent mechanism, providing new insight into the role of estrogen in iron metabolism.	Iron	139-143	bone morphogenetic protein 6	Mus musculus	62-66
25744452-1	2015	Heme oxygenase-1 (HO-1) catabolizes the degradation of heme into bilirubin, carbon monoxide, and iron ions.	Iron	97-101	heme oxygenase 1	Homo sapiens	18-22
25685776-8	2015	In addition, a negative correlation was found between pparalpha expression, TBARS, carbonyl protein, and iron stores.	Iron	105-109	peroxisome proliferator activated receptor alpha	Rattus norvegicus	54-63
22629388-12	2012	Liver Hamp mRNA, Bmp6 mRNA and Id1 mRNA displayed the expected response to iron overload and iron deficiency.	Iron	75-79	bone morphogenetic protein 6	Mus musculus	17-21
25416640-1	2015	Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	122-130
22563477-3	2012	The Slc39a8(neo) allele is associated with diminished zinc and iron uptake in mouse fetal fibroblast and liver-derived cultures; consequently, Slc39a8(neo/neo) newborns exhibit diminished zinc and iron levels in several tissues.	Iron	63-67	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	4-11
22563477-3	2012	The Slc39a8(neo) allele is associated with diminished zinc and iron uptake in mouse fetal fibroblast and liver-derived cultures; consequently, Slc39a8(neo/neo) newborns exhibit diminished zinc and iron levels in several tissues.	Iron	197-201	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	4-11
22563477-3	2012	The Slc39a8(neo) allele is associated with diminished zinc and iron uptake in mouse fetal fibroblast and liver-derived cultures; consequently, Slc39a8(neo/neo) newborns exhibit diminished zinc and iron levels in several tissues.	Iron	197-201	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	143-150
22586470-1	2012	Hepcidin is a regulatory hormone that plays a major role in controlling body iron homeostasis.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
25217489-12	2015	The only haematological parameter that was associated with outcome was hepcidin concentration, which is a novel finding and introduces further complexity into our understanding of the role of iron and its regulation by hepcidin.	Iron	192-196	hepcidin antimicrobial peptide	Homo sapiens	71-79
22586470-4	2012	Our aims were: a. to measure hepcidin expression at either hepatic, serum and urinary level in three paradigmatic iron overload conditions (hemochromatosis, thalassemia and dysmetabolic iron overload syndrome) and in controls; b. to measure mRNA hepcidin expression in two different hepatic cell lines (HepG2 and Huh-7) exposed to patients and controls sera to assess whether circulating factors could influence hepcidin transcription in different pathological conditions.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	29-37
23196478-2	2012	In these cells, iron absorption, storage, and export are critically regulated by several iron-metabolism proteins, including hepcidin.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	125-133
23196478-2	2012	In these cells, iron absorption, storage, and export are critically regulated by several iron-metabolism proteins, including hepcidin.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	125-133
25217489-12	2015	The only haematological parameter that was associated with outcome was hepcidin concentration, which is a novel finding and introduces further complexity into our understanding of the role of iron and its regulation by hepcidin.	Iron	192-196	hepcidin antimicrobial peptide	Homo sapiens	219-227
25300398-1	2015	PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene.	Iron	9-13	bone morphogenetic protein 6	Mus musculus	65-93
22285159-0	2012	Role of hepcidin in iron metabolism and potential clinical applications.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	8-16
22285159-1	2012	The relatively recent discovery of hepcidin has stimulated renewed research interest in iron metabolism and iron-related disorders, emphasizing the importance of this hormone in many normal and pathologic processes.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	35-43
22285159-1	2012	The relatively recent discovery of hepcidin has stimulated renewed research interest in iron metabolism and iron-related disorders, emphasizing the importance of this hormone in many normal and pathologic processes.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	35-43
21871825-0	2011	A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload.	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	36-43
21871825-1	2011	BACKGROUND: DMT1 is a transmembrane iron transporter involved in iron duodenal absorption and cellular iron uptake.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	12-16
21871825-1	2011	BACKGROUND: DMT1 is a transmembrane iron transporter involved in iron duodenal absorption and cellular iron uptake.	Iron	65-69	solute carrier family 11 member 2	Homo sapiens	12-16
21871825-2	2011	Mutations in the human SLC11A2 gene coding DMT1 lead to microcytic anemia and hepatic iron overload, with unexpectedly low levels of plasma ferritin in the presence of iron stores.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	23-30
21871825-2	2011	Mutations in the human SLC11A2 gene coding DMT1 lead to microcytic anemia and hepatic iron overload, with unexpectedly low levels of plasma ferritin in the presence of iron stores.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	43-47
21871825-2	2011	Mutations in the human SLC11A2 gene coding DMT1 lead to microcytic anemia and hepatic iron overload, with unexpectedly low levels of plasma ferritin in the presence of iron stores.	Iron	168-172	solute carrier family 11 member 2	Homo sapiens	23-30
21871825-2	2011	Mutations in the human SLC11A2 gene coding DMT1 lead to microcytic anemia and hepatic iron overload, with unexpectedly low levels of plasma ferritin in the presence of iron stores.	Iron	168-172	solute carrier family 11 member 2	Homo sapiens	43-47
21989655-1	2011	The reactions of heteroleptic GaCp*/CO containing transition metal complexes of iron and cobalt, namely [(CO)(3)M(mu(2)-GaCp*)(m)M(CO)(3)] (Cp* = pentamethylcyclopentadienyl; M = Fe, m = 3; M = Co, m = 2) and [Fe(CO)(4)(GaCp*)], with ZnMe(2) in toluene and the presence of a coordinating co-solvent were investigated.	Iron	80-84	glutaminase	Homo sapiens	30-34
22171055-0	2011	Ceruloplasmin oxidation, a feature of Parkinson"s disease CSF, inhibits ferroxidase activity and promotes cellular iron retention.	Iron	115-119	ceruloplasmin	Homo sapiens	0-13
22171055-2	2011	Ceruloplasmin is an extracellular ferroxidase that regulates cellular iron loading and export, and hence protects tissues from oxidative damage.	Iron	70-74	ceruloplasmin	Homo sapiens	0-13
22171055-9	2011	From the functional point of view, ceruloplasmin oxidation caused a decrease in ferroxidase activity, which in turn promotes intracellular iron retention in neuronal cell lines as well as in primary neurons, which are more sensitive to iron accumulation.	Iron	139-143	ceruloplasmin	Homo sapiens	35-48
22171055-9	2011	From the functional point of view, ceruloplasmin oxidation caused a decrease in ferroxidase activity, which in turn promotes intracellular iron retention in neuronal cell lines as well as in primary neurons, which are more sensitive to iron accumulation.	Iron	236-240	ceruloplasmin	Homo sapiens	35-48
21911012-1	2011	Hepcidin is a key player in the regulation of iron homeostasis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
21911012-2	2011	Several pathological conditions associated with iron overload are attributed to the depressed expression of hepcidin and are often associated with bone diseases including osteoporosis.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	108-116
21911012-3	2011	Hepcidin was suggested to have anti-osteoporosis effects by preventing iron overload.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	65-69	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	80-84
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	65-69	Tis11p	Saccharomyces cerevisiae S288C	85-89
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	168-172	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	80-84
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	168-172	Tis11p	Saccharomyces cerevisiae S288C	85-89
22071701-0	2011	Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	41-49
22071701-1	2011	BACKGROUND: The iron-regulatory hormone hepcidin has not been studied in infants, who experience large physiologic changes in iron status.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	40-48
22071701-2	2011	OBJECTIVE: The objective was to study hepcidin and erythropoietin and their correlation with iron status in iron-replete and iron-deficient low-birth-weight (LBW) infants-a group at particular risk of iron deficiency (ID).	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	38-46
22071701-2	2011	OBJECTIVE: The objective was to study hepcidin and erythropoietin and their correlation with iron status in iron-replete and iron-deficient low-birth-weight (LBW) infants-a group at particular risk of iron deficiency (ID).	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	38-46
22071701-6	2011	In iron-supplemented infants, hepcidin increased significantly, reaching a mean (+-SD) concentration of 19.2 +- 2.5 ng/mL in the 2-mg/kg group compared with 13.0 +- 2.6 ng/mL in the placebo group at age 6 mo (P &lt; 0.001).	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	30-38
22071701-11	2011	CONCLUSIONS: Hepcidin is closely associated with iron status and may be a useful indicator of iron stores and ID in infants.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	13-21
22071701-11	2011	CONCLUSIONS: Hepcidin is closely associated with iron status and may be a useful indicator of iron stores and ID in infants.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	13-21
21625916-11	2011	To the best of our knowledge this is the first report on the transformation of pineapple with soybean ferritin for enhanced accumulation of iron and zinc content in the transgenic plants.	Iron	140-144	ferritin-1, chloroplastic	Glycine max	102-110
21989113-1	2011	BACKGROUND: The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	32-40
21989113-1	2011	BACKGROUND: The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	32-40
21989113-3	2011	The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	19-27
21989113-6	2011	SUMMARY: Cell-culture, animal, and human studies have shown that hepcidin is predominantly synthesized by hepatocytes, where its expression is regulated by body iron status, erythropoietic activity, oxygen tension, and inflammatory cytokines.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	65-73
21989113-7	2011	Hepcidin lowers serum iron concentrations by counteracting the function of ferroportin, a major cellular iron exporter present in the membrane of macrophages, hepatocytes, and the basolateral site of enterocytes.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
21989113-7	2011	Hepcidin lowers serum iron concentrations by counteracting the function of ferroportin, a major cellular iron exporter present in the membrane of macrophages, hepatocytes, and the basolateral site of enterocytes.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
21359624-1	2011	BACKGROUND: Recent evidence suggests that the duodenum can regulate iron absorption independently of hepcidin via the transcription factor Hif-2alpha acting directly on the transcription of the proteins involved in the iron transport.	Iron	68-72	endothelial PAS domain protein 1	Mus musculus	139-149
21359624-1	2011	BACKGROUND: Recent evidence suggests that the duodenum can regulate iron absorption independently of hepcidin via the transcription factor Hif-2alpha acting directly on the transcription of the proteins involved in the iron transport.	Iron	219-223	endothelial PAS domain protein 1	Mus musculus	139-149
21359624-6	2011	Increased iron absorption reported in early hypoxia could be accounted for in part by the enhancement of Dcytb expression by Hif-2alpha in the duodenum.	Iron	10-14	endothelial PAS domain protein 1	Mus musculus	125-135
21359624-7	2011	CONCLUSION: Modulation of Hif-2alpha predominates over hepcidin in the regulation of intestinal iron absorption during short hypoxic duration.	Iron	96-100	endothelial PAS domain protein 1	Mus musculus	26-36
21478213-4	2011	Potential mechanisms behind iron deficiency in IPAH include inhibition of dietary iron uptake by the master iron regulator hepcidin.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	123-131
21478213-4	2011	Potential mechanisms behind iron deficiency in IPAH include inhibition of dietary iron uptake by the master iron regulator hepcidin.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	123-131
21859731-8	2011	Reduced SMAD1/5/8 activity in association with phlebotomy was paralleled by increased expression of the inhibitory factor, SMAD7, dietary iron restriction appeared to impair hepcidin transactivating SMAD pathways via reduction of membrane bound hemojuvelin expression.	Iron	138-142	hemojuvelin BMP co-receptor	Rattus norvegicus	245-256
21963450-1	2011	Lactoferrin (Ltf), an iron binding glycoprotein, is a pleiotropic molecule whose serum concentration increases under acute phase conditions.	Iron	22-26	lactotransferrin	Mus musculus	0-11
21963450-1	2011	Lactoferrin (Ltf), an iron binding glycoprotein, is a pleiotropic molecule whose serum concentration increases under acute phase conditions.	Iron	22-26	lactotransferrin	Mus musculus	13-16
21917924-0	2011	Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity.	Iron	79-83	Yap5p	Saccharomyces cerevisiae S288C	0-4
21917924-1	2011	The budding yeast Saccharomyces cerevisiae responds to high cytosolic iron by inducing Yap5-mediated transcription.	Iron	70-74	Yap5p	Saccharomyces cerevisiae S288C	87-91
21917924-2	2011	We identified genes regulated by Yap5 in response to iron and show that one of the genes induced is TYW1, which encodes an iron-sulfur cluster enzyme that participates in the synthesis of wybutosine-modified tRNA.	Iron	53-57	Yap5p	Saccharomyces cerevisiae S288C	33-37
21917924-2	2011	We identified genes regulated by Yap5 in response to iron and show that one of the genes induced is TYW1, which encodes an iron-sulfur cluster enzyme that participates in the synthesis of wybutosine-modified tRNA.	Iron	123-127	Yap5p	Saccharomyces cerevisiae S288C	33-37
21917924-6	2011	CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of either CCC1 or YAP5 resulted in high iron sensitivity.	Iron	17-21	Yap5p	Saccharomyces cerevisiae S288C	37-41
22019085-2	2011	Systemic iron homeostasis in vertebrates is regulated by the hepcidin-mediated internalization of Fpn.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	61-69
21958231-2	2011	The circulating peptide hormone hepcidin, the central regulator of iron distribution in mammals, holds great diagnostic potential for an array of iron-associated disorders, including iron loading (beta-thalassemia), iron overload (hereditary hemochromatosis), and iron deficiency diseases.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	32-40
21958231-2	2011	The circulating peptide hormone hepcidin, the central regulator of iron distribution in mammals, holds great diagnostic potential for an array of iron-associated disorders, including iron loading (beta-thalassemia), iron overload (hereditary hemochromatosis), and iron deficiency diseases.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	32-40
21958231-2	2011	The circulating peptide hormone hepcidin, the central regulator of iron distribution in mammals, holds great diagnostic potential for an array of iron-associated disorders, including iron loading (beta-thalassemia), iron overload (hereditary hemochromatosis), and iron deficiency diseases.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	32-40
21958231-2	2011	The circulating peptide hormone hepcidin, the central regulator of iron distribution in mammals, holds great diagnostic potential for an array of iron-associated disorders, including iron loading (beta-thalassemia), iron overload (hereditary hemochromatosis), and iron deficiency diseases.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	32-40
21811788-6	2011	The level of 70 kDa heat shock cognate (HSC70) expression was greater in the diencephalon of the 3 ppm Fe group.	Iron	103-105	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	40-45
21863061-0	2011	Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	18-29
21863061-2	2011	Furthermore, latest reports described BMPs, in particular BMP6, as important regulators of hepcidin expression in iron homeostasis.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	91-99
21863061-7	2011	To identify a possible regulatory mechanism causing lack of reaction to BMP4 we analyzed the expression of hemojuvelin (HJV), which is involved in iron metabolism as BMP co-receptor.	Iron	147-151	hemojuvelin BMP co-receptor	Homo sapiens	107-118
21863061-7	2011	To identify a possible regulatory mechanism causing lack of reaction to BMP4 we analyzed the expression of hemojuvelin (HJV), which is involved in iron metabolism as BMP co-receptor.	Iron	147-151	hemojuvelin BMP co-receptor	Homo sapiens	120-123
25300398-1	2015	PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene.	Iron	9-13	bone morphogenetic protein 6	Mus musculus	95-99
22057958-5	2011	Sequence analysis showed that five binding sites of iron, including  two consensus histidines in the LOX domain, are highly conserved in the  cucumber LOX proteins.	Iron	52-56	linoleate 9S-lipoxygenase 6-like	Cucumis sativus	101-104
22057958-5	2011	Sequence analysis showed that five binding sites of iron, including  two consensus histidines in the LOX domain, are highly conserved in the  cucumber LOX proteins.	Iron	52-56	linoleate 9S-lipoxygenase 6-like	Cucumis sativus	151-154
25300398-1	2015	PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene.	Iron	158-162	bone morphogenetic protein 6	Mus musculus	65-93
25300398-1	2015	PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene.	Iron	158-162	bone morphogenetic protein 6	Mus musculus	95-99
21768301-7	2011	In preclinical experiments using interventions such as transferrin, hepcidin agonists, and JAK2 inhibitors, we provide evidence of potential new treatment alternatives that elucidate mechanisms by which expanded or ineffective erythropoiesis may regulate iron supply, distribution, and utilization in diseases such as beta-thalassemia.	Iron	255-259	hepcidin antimicrobial peptide	Homo sapiens	68-76
25300398-5	2015	RESULTS: In WT mice, 4 h following iron challenge, liver Bmp6 and hepcidin expression were increased, while expression of other Bmps was not affected.	Iron	35-39	bone morphogenetic protein 6	Mus musculus	57-61
25300398-6	2015	In parallel, we provided the first evidence that BMP6 circulates in WT mice and that iron increased the BMP6 serum level and the specific liver uptake of (99m)Tc-BMP6.	Iron	85-89	bone morphogenetic protein 6	Mus musculus	104-108
25300398-6	2015	In parallel, we provided the first evidence that BMP6 circulates in WT mice and that iron increased the BMP6 serum level and the specific liver uptake of (99m)Tc-BMP6.	Iron	85-89	bone morphogenetic protein 6	Mus musculus	104-108
25300398-7	2015	In Bmp6-/- mice, iron challenge led to blunted activation of liver Smad signaling and hepcidin expression with a delay of 24 h, associated with increased Bmp5 and Bmp7 expression and increased Bmp2, 4, 5 and 9 expression in the duodenum.	Iron	17-21	bone morphogenetic protein 6	Mus musculus	3-7
21712541-0	2011	Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation.	Iron	112-116	ferritin mitochondrial	Homo sapiens	19-41
25300398-10	2015	CONCLUSION: In Bmp6-/- mice, iron activated endogenous compensatory mechanisms of other BMPs that were not sufficient for preventing hemochromatosis and bone loss.	Iron	29-33	bone morphogenetic protein 6	Mus musculus	15-19
21601942-5	2011	Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene.	Iron	52-56	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	142-148
25624418-9	2015	FtMt overexpression reduced iron-mediated expression of amyloid-beta protein precursor and decreased NF-kappaB-dependent increases in beta- and gamma-secretase, leading to decreased amyloid-beta production.	Iron	28-32	ferritin mitochondrial	Homo sapiens	0-4
22230411-0	2011	Lactoferrin decreases inflammatory response by cystic fibrosis bronchial cells invaded with Burkholderia cenocepacia iron-modulated biofilm.	Iron	117-121	lactotransferrin	Bos taurus	0-11
22230411-3	2011	Lactoferrin (Lf), an iron binding multifunctional glycoprotein synthesized by exocrine glands and neutrophils, has been found at higher concentration in the airway secretions of infected CF patients than in healthy subjects.	Iron	21-25	lactotransferrin	Bos taurus	0-11
26756421-6	2015	Expression of the iron-related proteins ferritin, DMT1, and FPN1 was elevated in lung tissue from the six asbestosis patients relative to controls.	Iron	18-22	solute carrier family 11 member 2	Homo sapiens	50-54
22230411-4	2011	Here the influence of milk derivative bovine lactoferrin (bLf), an emerging important regulator of iron and inflammatory homeostasis, on invasiveness of B. cenocepacia iron-modulated biofilm, as well as on inflammatory response by infected CF bronchial (IB3-1) cells, is reported.	Iron	99-103	lactotransferrin	Bos taurus	45-56
22230411-4	2011	Here the influence of milk derivative bovine lactoferrin (bLf), an emerging important regulator of iron and inflammatory homeostasis, on invasiveness of B. cenocepacia iron-modulated biofilm, as well as on inflammatory response by infected CF bronchial (IB3-1) cells, is reported.	Iron	168-172	lactotransferrin	Bos taurus	45-56
21901209-1	2011	In healthy subjects, the rate of dietary iron absorption, as well as the amount and distribution of body iron are tightly controlled by hepcidin, the iron regulatory hormone.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	136-144
26756421-6	2015	Expression of the iron-related proteins ferritin, DMT1, and FPN1 was elevated in lung tissue from the six asbestosis patients relative to controls.	Iron	18-22	solute carrier family 40 member 1	Homo sapiens	60-64
26053506-5	2015	Finally, we partially purified and identified essential metals, Fe, Zn, Co, Ni and Mn, as novel OGR1 agonists.	Iron	64-66	G protein-coupled receptor 68	Homo sapiens	96-100
26053506-8	2015	Here, we demonstrate that metals, Fe, Zn, Co, Ni and Mn are the novel OGR1 agonists, which can singly activate OGR1 in neutral pH.	Iron	34-36	G protein-coupled receptor 68	Homo sapiens	70-74
21719465-0	2011	Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer.	Iron	24-28	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	109-114
26053506-8	2015	Here, we demonstrate that metals, Fe, Zn, Co, Ni and Mn are the novel OGR1 agonists, which can singly activate OGR1 in neutral pH.	Iron	34-36	G protein-coupled receptor 68	Homo sapiens	111-115
25204225-7	2015	The discovery of hepcidin and ferroportin and their interaction in regulating the release of iron from enterocytes and macrophages to plasma were important milestones.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	17-25
21708394-3	2011	Initial tests conducted using continuous flow, small-scale glass columns showed high MS2 bacteriophage removal in an iron-amended sand column (5log10) compared to a sand-only column (0.5log10) over 20 pore volumes.	Iron	117-121	MS2	Homo sapiens	85-88
25204225-9	2015	Inhibited transcription induced by the altered function of mutated gene products, results in low plasma levels of hepcidin which facilitate entry of iron from enterocytes into plasma.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	114-122
21917813-4	2011	Iron export, a key mechanism to maintain proper levels in cells, occurs via ferroportin, a ubiquitously expressed transmembrane protein that partners with a ferroxidase.	Iron	0-4	ceruloplasmin	Mus musculus	157-168
21917813-5	2011	A membrane-bound form of the ferroxidase ceruloplasmin is expressed by astrocytes in the CNS and regulates iron efflux.	Iron	107-111	ceruloplasmin	Mus musculus	29-40
25204225-11	2015	Being the major site of excess iron storage and hepcidin synthesis the liver is a cornerstone in maintaining normal systemic iron homeostasis.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	48-56
21907923-2	2011	Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha.	Iron	108-112	endothelial PAS domain protein 1	Homo sapiens	256-266
26160488-3	2015	The key element involved in iron metabolism is hepcidin, however, studies on new indices of iron status are in progress.The aim of the study was to assess the iron status in patients in early stages of chronic kidney disease, iron correlation with inflammation parameters and novel biomarkers of iron metabolism.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	47-55
21700773-0	2011	Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	29-37
25442715-0	2015	Nanocapsules loaded with iron-saturated bovine lactoferrin have antimicrobial therapeutic potential and maintain calcium, zinc and iron metabolism.	Iron	25-29	lactotransferrin	Bos taurus	47-58
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	132-136
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	29-37
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	132-136
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	29-37
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	132-136
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	29-37
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	132-136
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	29-37
21700773-1	2011	The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	132-136
21700773-2	2011	We previously demonstrated that FPN1 was highly expressed in erythroblasts, a cell type that consumes most of the serum iron for use in hemoglobin synthesis.	Iron	120-124	solute carrier family 40 member 1	Homo sapiens	32-36
21700773-3	2011	Herein, we have demonstrated that FPN1 localizes to the plasma membrane of erythroblasts, and hepcidin treatment leads to decreased expression of FPN1 and a subsequent increase in intracellular iron concentrations in both erythroblast cell lines and primary erythroblasts.	Iron	194-198	solute carrier family 40 member 1	Homo sapiens	34-38
21700773-3	2011	Herein, we have demonstrated that FPN1 localizes to the plasma membrane of erythroblasts, and hepcidin treatment leads to decreased expression of FPN1 and a subsequent increase in intracellular iron concentrations in both erythroblast cell lines and primary erythroblasts.	Iron	194-198	hepcidin antimicrobial peptide	Homo sapiens	94-102
25442715-0	2015	Nanocapsules loaded with iron-saturated bovine lactoferrin have antimicrobial therapeutic potential and maintain calcium, zinc and iron metabolism.	Iron	131-135	lactotransferrin	Bos taurus	47-58
21700773-4	2011	Moreover, injection of exogenous hepcidin decreased FPN1 expression in BM erythroblasts in vivo, whereas iron depletion and associated hepcidin reduction led to increased FPN1 expression in erythroblasts.	Iron	105-109	solute carrier family 40 member 1	Homo sapiens	171-175
21700773-5	2011	Taken together, hepcidin decreased FPN1 expression and increased intracellular iron availability of erythroblasts.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	16-24
25442715-1	2015	AIM: This study aimed to evaluate the potential antimicrobial efficacy of alginate gel-encapsulated ceramic nanocarriers loaded with iron-saturated bovine lactoferrin (Fe-bLf) nanocarriers/nanocapsules (AEC-CP-Fe-bLf NCs).	Iron	133-137	lactotransferrin	Bos taurus	155-166
21700773-6	2011	We hypothesize that FPN1 expression in erythroblasts allows fine-tuning of systemic iron utilization to ensure that erythropoiesis is partially suppressed when nonerythropoietic tissues risk developing iron deficiency.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	20-24
25867858-8	2015	Both T2* and apparent diffusion coefficient measurements confirmed their enhanced magnetic targeting starting from 2 h postinjection while a lower, but statistically significant enhanced targeting of antibody-conjugated active targeting was observed starting from 24 h postinjection of iron-tagged SWCNT + CD105 samples.	Iron	286-290	endoglin	Mus musculus	306-311
21561784-4	2011	FE were also responsible for a rapid and transient increase in free cytosolic Ca(2+) in Nicotiana plumbaginifolia and tobacco cells, and pre-treatment with a Ca(2+)-channel blocker (La(3+)) showed that in these cells, MAPK activation was dependent on the cytosolic Ca(2+) increase.	Iron	0-2	mitogen-activated protein kinase 7-like	Nicotiana tabacum	218-222
21561784-6	2011	Our results show that MAPK activation is triggered by an FE-induced cytosolic Ca(2+) transient, and that a Sym genetic determinant acts to modulate the intensity and duration of this activity.	Iron	57-59	mitogen-activated protein kinase 7-like	Nicotiana tabacum	22-26
25703232-8	2015	We have demonstrated an interaction between the mutant huntingtin gene and iron supplementation in neonatal HD mice.	Iron	75-79	huntingtin	Mus musculus	55-65
21720790-1	2011	The objective of this study was to evaluate the effect of proanthocyanidins (PAs) on iron uptake from soybean seed ferritin (SSF) crude by rats with iron deficiency anemia (IDA) for the first time.	Iron	85-89	ferritin-1, chloroplastic	Glycine max	115-123
25587028-2	2014	Concurrent attenuation of oxidative phosphorylation and HIF-1alpha/PKM2-dependent glycolysis promotes a non-apoptotic, iron- and oxygen-dependent cell death that we term ferroxitosis.	Iron	119-123	pyruvate kinase M1/2	Homo sapiens	67-71
21724843-1	2011	The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	154-162
25398878-9	2014	The IscR-dependent activation of prx3 by aerobic growth and iron starvation was also associated with the increase in cellular levels of IscR protein.	Iron	60-64	peroxiredoxin 3	Mus musculus	33-37
21724843-1	2011	The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism.	Iron	190-194	hepcidin antimicrobial peptide	Homo sapiens	154-162
21724843-8	2011	Our results underscore for the first time the importance of TMPRSS6 trafficking at the plasma membrane in the regulation of hepcidin expression, an event that is essential for iron homeostasis.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	124-132
25398878-10	2014	Taken together, the results suggested that IscR senses iron starvation as well as reactive oxygen species and shifts to the apo-form, which leads to the increase of cellular IscR and in turn prx3 expression, contributing to the survival and virulence of V. vulnificus during pathogenesis.	Iron	55-59	peroxiredoxin 3	Mus musculus	191-195
25241054-1	2014	Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting enzymatic step of heme degradation and produces carbon monoxide, free iron, and biliverdin.	Iron	132-136	heme oxygenase 1	Homo sapiens	0-16
25241054-1	2014	Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting enzymatic step of heme degradation and produces carbon monoxide, free iron, and biliverdin.	Iron	132-136	heme oxygenase 1	Homo sapiens	18-22
21609320-1	2011	Hepcidin, a hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
21609320-3	2011	Abnormal levels of hepcidin expression alter plasma iron parameters and lead to iron metabolism disorders.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	19-27
21609320-3	2011	Abnormal levels of hepcidin expression alter plasma iron parameters and lead to iron metabolism disorders.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	19-27
25696858-2	2014	In both disorders, inappropriately low levels of the liver hormone hepcidin are responsible for the increased iron absorption, leading to toxic iron accumulation in many organs.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	67-75
21079975-3	2011	Intracellularly, heme oxygenase-1 (HO1) participates in the cleavage of the heme ring producing biliverdin, CO and ferrous iron.	Iron	123-127	heme oxygenase 1	Homo sapiens	17-33
21079975-3	2011	Intracellularly, heme oxygenase-1 (HO1) participates in the cleavage of the heme ring producing biliverdin, CO and ferrous iron.	Iron	123-127	heme oxygenase 1	Homo sapiens	35-38
21079975-6	2011	OBJECTIVE: This study focused on the uptake and transport of heme iron and on the role of heme oxygenase-1 on heme iron metabolism.	Iron	115-119	heme oxygenase 1	Homo sapiens	90-106
21079975-8	2011	A full-length heme oxygenase-1 cDNA was expressed in Caco-2 cells and intracellular iron and heme-Fe content, heme uptake, heme and iron transport and heme oxygenase-1 immunolocalization were assessed in these cells.	Iron	84-88	heme oxygenase 1	Homo sapiens	14-30
21079975-10	2011	In cells overexpressing HO1, heme-Fe uptake and transepithelial Fe transport was higher than in controls.	Iron	34-36	heme oxygenase 1	Homo sapiens	24-27
25696858-2	2014	In both disorders, inappropriately low levels of the liver hormone hepcidin are responsible for the increased iron absorption, leading to toxic iron accumulation in many organs.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	67-75
21079975-10	2011	In cells overexpressing HO1, heme-Fe uptake and transepithelial Fe transport was higher than in controls.	Iron	64-66	heme oxygenase 1	Homo sapiens	24-27
25541657-1	2014	OBJECTIVE: Hepcidin plays a pivotal role in iron homeostasis.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	11-19
21079975-14	2011	CONCLUSIONS: These results suggest that heme oxygenase-1 catabolizes most of the heme-Fe and favors iron influx and efflux in intestinal cells.	Iron	100-104	heme oxygenase 1	Homo sapiens	40-56
21654321-0	2011	Blunted increase in serum hepcidin as response to oral iron in HFE-hemochromatosis.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	26-34
21654321-4	2011	However, the precise link between hepcidin levels and iron absorption in HFE-H patients has been poorly understood.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	34-42
21654321-5	2011	AIM: To measure hepcidin response to oral iron challenge (200 mg ferrous sulphate), in HFE-H (C282Y/C282Y) patients and compare with healthy controls (HCs).	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	16-24
21654321-8	2011	Hepcidin was measured using a published immunoassay method after ingestion of 65 mg oral iron challenge.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
21654321-12	2011	Incremental serum hepcidin response seen in HC reached significance at 4 h post iron challenge (P=0.0085) returning to baseline only at 24 h. There was no significant hepcidin response in HFE-H at 4 h (P=0.294).	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	18-26
25541657-4	2014	This study aims to discuss the role of hepcidin in the pathogenesis of iron overload in recently diagnosed myelodysplasia (MDS) cases.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	39-47
21654321-14	2011	CONCLUSION: Failure to mount a rapid hepcidin response to an oral iron challenge is the key mechanisms of iron accumulation despite prevailing excess body iron in patients with HFE-H with C282Y/C282Y mutation.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	37-45
21654321-14	2011	CONCLUSION: Failure to mount a rapid hepcidin response to an oral iron challenge is the key mechanisms of iron accumulation despite prevailing excess body iron in patients with HFE-H with C282Y/C282Y mutation.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	37-45
25280951-5	2014	The transfer of heme iron from either intact or digested forms of hemoglobin and myoglobin and from intact ferritin was demonstrated by in vitro methods, monitoring Fe-saturation status of Lf by changes in absorptivity at 465 nm.	Iron	165-167	lactotransferrin	Bos taurus	189-191
21654321-14	2011	CONCLUSION: Failure to mount a rapid hepcidin response to an oral iron challenge is the key mechanisms of iron accumulation despite prevailing excess body iron in patients with HFE-H with C282Y/C282Y mutation.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	37-45
25280951-6	2014	The results are discussed in the context of new proposed opportunities for orally administered Lf to regulate oxidative damage associated with heme iron.	Iron	148-152	lactotransferrin	Bos taurus	95-97
25280951-7	2014	In addition to potentially suppressing oxidative heme-iron-mediated tissue damage in the lumen, Lf is expected to also reverse the overload of ferritin-bound iron, that accompanies chronic inflammation and aging.	Iron	54-58	lactotransferrin	Bos taurus	96-98
25280951-7	2014	In addition to potentially suppressing oxidative heme-iron-mediated tissue damage in the lumen, Lf is expected to also reverse the overload of ferritin-bound iron, that accompanies chronic inflammation and aging.	Iron	158-162	lactotransferrin	Bos taurus	96-98
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	156-164
25380676-10	2014	Moreover, iron supplementation at high altitudes affected HIF-1alpha-mediated regulating expression of targeting genes such as EPO and transferrin.	Iron	10-14	erythropoietin	Rattus norvegicus	127-130
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	156-164
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	156-164
21475976-5	2011	Hepcidin concentrations are inappropriately low in CDAII patients considering the severe hepatic iron overload associated with this disorder.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
25153906-3	2014	Iron homeostasis is controlled by the circulating peptide hepcidin and its production is influenced by inflammatory cytokines.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	58-66
20392616-9	2011	Hyperferritinemia was associated with increased vascular damage only in patients with HFE genotypes associated with hepcidin upregulation by iron stores (p&lt;0.0001), and serum hepcidin-25 was independently associated with carotid plaques (p=0.05).	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	116-124
20392616-11	2011	The mechanism may involve upregulation of hepcidin by increased iron stores in patients not carrying HFE mutations, and iron compartmentalization into macrophages.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	42-50
24735882-7	2014	CONCLUSION: The sTfR is not useful to determine the iron status in this population, whereas hepcidin might serve as an early indicator of deficient iron stores in children with CF.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	92-100
21311510-0	2011	Hemojuvelin: a new link between obesity and iron homeostasis.	Iron	44-48	hemojuvelin BMP co-receptor	Homo sapiens	0-11
25111043-4	2014	Induction of the glial HMOX1 gene may lead to pathological brain iron deposition, intracellular oxidative damage, and bioenergetic failure in AD and other human CNS disorders such as PD and MS.	Iron	65-69	heme oxygenase 1	Homo sapiens	23-28
21683124-8	2011	Studies using western blot and gelatin zymography analyses demonstrated that increased cellular iron levels in activated microglia enhanced the secretion of MMP-9 and MMP-1.	Iron	96-100	matrix metallopeptidase 1	Rattus norvegicus	167-172
25335768-3	2014	The nanoparticles encapsulating ribavirin monophosphate (RMP) were prepared from the blend of poly(d,l-lactic acid) homopolymer and arabinogalactan (AG)-poly(l-lysine) conjugate by using the solvent diffusion method in the presence of iron (III).	Iron	235-239	URI1 prefoldin like chaperone	Homo sapiens	32-61
21622652-2	2011	Patients with IRIDA have inappropriately elevated levels of the iron regulatory hormone hepcidin, suggesting that TMPRSS6 is involved in negatively regulating hepcidin expression.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	88-96
21622652-2	2011	Patients with IRIDA have inappropriately elevated levels of the iron regulatory hormone hepcidin, suggesting that TMPRSS6 is involved in negatively regulating hepcidin expression.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	159-167
21771327-6	2011	Hepcidin increased significantly in non-obese children with IDA after 3 months of iron therapy (P &lt; 0.01).	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
21771327-7	2011	On the other hand, obese children showed non-significant change in hepcidin level after iron therapy (p &gt; 0.05).	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	67-75
21771327-8	2011	Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P &lt; 0.05).	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	9-17
21771327-8	2011	Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P &lt; 0.05).	Iron	197-201	hepcidin antimicrobial peptide	Homo sapiens	9-17
21737024-15	2011	Inappropriately raised hepcidin levels, which impair iron absorption from the gut, may be a factor.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	23-31
21703414-7	2011	Intraocular Bmp6 protein injection in mice up-regulated retinal hepcidin, an iron regulatory hormone, and altered retinal labile iron levels.	Iron	77-81	bone morphogenetic protein 6	Mus musculus	12-16
21703414-7	2011	Intraocular Bmp6 protein injection in mice up-regulated retinal hepcidin, an iron regulatory hormone, and altered retinal labile iron levels.	Iron	129-133	bone morphogenetic protein 6	Mus musculus	12-16
21473866-0	2011	Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion.	Iron	85-89	hephaestin	Rattus norvegicus	37-47
21473866-10	2011	Reduced interactions between Fpn and Heph after iron ingestion indicate that this is a regulatory mechanism for limiting further iron absorption.	Iron	48-52	hephaestin	Rattus norvegicus	37-41
21473866-10	2011	Reduced interactions between Fpn and Heph after iron ingestion indicate that this is a regulatory mechanism for limiting further iron absorption.	Iron	129-133	hephaestin	Rattus norvegicus	37-41
21488083-0	2011	Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice.	Iron	16-20	bone morphogenetic protein 6	Mus musculus	46-74
21488083-0	2011	Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice.	Iron	16-20	bone morphogenetic protein 6	Mus musculus	76-80
21488083-1	2011	UNLABELLED: The bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway is a central regulator of hepcidin expression and systemic iron balance.	Iron	134-138	bone morphogenetic protein 6	Mus musculus	16-44
21488083-1	2011	UNLABELLED: The bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway is a central regulator of hepcidin expression and systemic iron balance.	Iron	134-138	bone morphogenetic protein 6	Mus musculus	46-50
21488083-2	2011	However, the molecular mechanisms by which iron is sensed to regulate BMP6-SMAD signaling and hepcidin expression are unknown.	Iron	43-47	bone morphogenetic protein 6	Mus musculus	70-74
21488083-5	2011	Although liver iron content is independently positively correlated with hepatic Bmp6 messenger RNA (mRNA) expression and overall activation of the Smad1/5/8 signaling pathway, transferrin saturation activates the downstream Smad1/5/8 signaling cascade, but does not induce Bmp6 mRNA expression in the liver.	Iron	15-19	bone morphogenetic protein 6	Mus musculus	80-84
21488083-5	2011	Although liver iron content is independently positively correlated with hepatic Bmp6 messenger RNA (mRNA) expression and overall activation of the Smad1/5/8 signaling pathway, transferrin saturation activates the downstream Smad1/5/8 signaling cascade, but does not induce Bmp6 mRNA expression in the liver.	Iron	15-19	SMAD family member 1	Mus musculus	147-154
21488083-5	2011	Although liver iron content is independently positively correlated with hepatic Bmp6 messenger RNA (mRNA) expression and overall activation of the Smad1/5/8 signaling pathway, transferrin saturation activates the downstream Smad1/5/8 signaling cascade, but does not induce Bmp6 mRNA expression in the liver.	Iron	15-19	bone morphogenetic protein 6	Mus musculus	273-277
21488083-8	2011	CONCLUSION: Our data demonstrate that the hepatic Bmp6-Smad signaling pathway is differentially activated by circulating and tissue iron to induce hepcidin expression, whereas the hepatic Erk1/2 signaling pathway is not activated by iron in vivo.	Iron	132-136	bone morphogenetic protein 6	Mus musculus	50-54
22023767-0	2011	Urinary hepcidin identifies a serum ferritin cut-off for iron supplementation in young athletes: a pilot study.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	8-16
22023767-4	2011	The aim of the present study is to evaluate the clinical usefulness of hepcidin assessment in the analysis of the iron status of young non-anemic athletes.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	71-79
22023767-10	2011	The present study suggests that serum ferritin levels below 30 microg/L indicate an asymptomatic iron deficiency status inhibiting hepcidin expression and that 30 microg/L should be considered the ferritin cut-off when considering an iron supplementation in young athletes.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	131-139
21418708-8	2011	The increase in SVCT1 expression correlated with an increase in ascorbic acid uptake (285 %) in Fe-treated cells, as indicated by the SVCT1 inhibitor quercetin.	Iron	96-98	solute carrier family 23 member 1	Homo sapiens	16-21
21418708-8	2011	The increase in SVCT1 expression correlated with an increase in ascorbic acid uptake (285 %) in Fe-treated cells, as indicated by the SVCT1 inhibitor quercetin.	Iron	96-98	solute carrier family 23 member 1	Homo sapiens	134-139
21595430-1	2011	This study investigated reductive dechlorination of cis-dichloroethylene (cis-DCE) by the reduced Fe phases obtained from in situ precipitation, which involved mixing of Fe(II), Fe(III), and S(-II) solutions.	Iron	98-100	transcription elongation factor A1	Homo sapiens	191-196
21315474-0	2011	Arabidopsis CYP82C4 expression is dependent on Fe availability and circadian rhythm, and correlates with genes involved in the early Fe deficiency response.	Iron	47-49	cytochrome P450, family 82, subfamily C, polypeptide 4	Arabidopsis thaliana	12-19
21315474-0	2011	Arabidopsis CYP82C4 expression is dependent on Fe availability and circadian rhythm, and correlates with genes involved in the early Fe deficiency response.	Iron	133-135	cytochrome P450, family 82, subfamily C, polypeptide 4	Arabidopsis thaliana	12-19
21315474-3	2011	From microarray analysis of Arabidopsis roots, it is known that three different cytochrome P450 genes, CYP82C4, CYP82C3 and CYP71B5 are up-regulated under Fe deficiency through a FIT-dependent pathway.	Iron	155-157	cytochrome P450, family 82, subfamily C, polypeptide 4	Arabidopsis thaliana	103-110
21315474-6	2011	While confirming that the CYP82C4 transcript accumulates in Fe-deficient Arabidopsis seedlings, with circadian fluctuations in a light-dependent way, we also demonstrate that such accumulation is suppressed under Fe excess.	Iron	60-62	cytochrome P450, family 82, subfamily C, polypeptide 4	Arabidopsis thaliana	26-33
21498508-6	2011	Genetic disruption of HIF-2alpha in the intestine abolished the increase in iron absorption genes as assessed by quantitative real-time reverse transcription-PCR and Western blot analyses.	Iron	76-80	endothelial PAS domain protein 1	Mus musculus	22-32
21498508-7	2011	Moreover, the increase in serum iron following induction of erythropoiesis was entirely dependent on intestinal HIF-2alpha expression.	Iron	32-36	endothelial PAS domain protein 1	Mus musculus	112-122
21498508-9	2011	These data further cement the essential role of HIF-2alpha in regulating iron absorption and also demonstrate that hypoxia sensing in the intestine, as well as in the kidney, is essential for regulation of erythropoiesis by HIF-2alpha.	Iron	73-77	endothelial PAS domain protein 1	Mus musculus	48-58
21396368-0	2011	Identification of mutations in SLC40A1 that affect ferroportin function and phenotype of human ferroportin iron overload.	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	31-38
21396368-1	2011	BACKGROUND &amp; AIMS: Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation.	Iron	49-53	solute carrier family 40 member 1	Homo sapiens	100-107
21396368-1	2011	BACKGROUND &amp; AIMS: Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation.	Iron	124-128	solute carrier family 40 member 1	Homo sapiens	100-107
21396368-2	2011	In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from SLC40A1 mutations that confer resistance of ferroportin to hepcidin-mediated inactivation.	Iron	28-32	solute carrier family 40 member 1	Homo sapiens	185-192
21396368-2	2011	In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from SLC40A1 mutations that confer resistance of ferroportin to hepcidin-mediated inactivation.	Iron	153-157	solute carrier family 40 member 1	Homo sapiens	185-192
21396368-2	2011	In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from SLC40A1 mutations that confer resistance of ferroportin to hepcidin-mediated inactivation.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	244-252
21396368-3	2011	METHODS: SLC40A1 was sequenced in patients from 2 independent pedigrees affected by hepatic iron overload unrelated to HFE.	Iron	92-96	solute carrier family 40 member 1	Homo sapiens	9-16
21396368-5	2011	RESULTS: A patient heterozygous for the variant p.W158C in SLC40A1 presented with macrophage iron overload, hyperferritinemia, and normal transferrin saturation.	Iron	93-97	solute carrier family 40 member 1	Homo sapiens	59-66
21396368-10	2011	CONCLUSIONS: The variant p.W158C in SLC40A1 impairs intracellular trafficking of ferroportin, resulting in reduced iron export.	Iron	115-119	solute carrier family 40 member 1	Homo sapiens	36-43
21438013-1	2011	Hepcidin, an iron-regulatory hormone, plays a central role in iron homeostasis in peripheral tissues.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	0-8
21438013-2	2011	The widespread distribution of hepcidin in the brain implies that the hormone may be essential for brain iron homeostasis.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	31-39
21438013-3	2011	Here, we investigated the effects of hepcidin on the expression of iron uptake proteins, including transferrin receptor 1 (TfR1) and divalent metal transporter1 (DMT1) and the release protein ferroportin1 (Fpn1) in the cultured astrocytes.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	37-45
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	60-68
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	94-102
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	94-102
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	181-185	solute carrier family 11 member 2	Homo sapiens	291-295
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	181-185	solute carrier family 40 member 1	Homo sapiens	301-305
21308772-8	2011	Moreover, iron downregulated mRNA levels of several other osteoblastogenic markers such as Runx2, osterix, osteopontin, and osteocalcin.	Iron	10-14	secreted phosphoprotein 1	Homo sapiens	107-118
21572427-5	2011	Inhibition of the liver-stage infection is mediated by the host iron regulatory hormone hepcidin, whose synthesis we found to be stimulated by blood-stage parasites in a density-dependent manner.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	88-96
21401731-6	2011	Liver transplant patients with Hp 1-1 and Hp 2-1 grafts had a better outcome probability than recipients of an Hp 2-2 graft, which may be explained by differences in iron metabolism induced by the Hp genotype of the graft.	Iron	166-170	chromobox 5	Homo sapiens	31-37
25441748-0	2014	Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease).	Iron	24-28	alpha-L-iduronidase	Homo sapiens	70-73
21393479-2	2011	In this highly prevalent form of anemia, inflammatory cytokines, including IL-6, stimulate hepatic expression of hepcidin, which negatively regulates iron bioavailability by inactivating ferroportin.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	113-121
21393479-9	2011	Our studies support the concept that BMP and IL-6 act together to regulate iron homeostasis and suggest that inhibition of BMP signaling may be an effective strategy for the treatment of anemia of inflammation.	Iron	75-79	bone morphogenetic protein 1	Homo sapiens	37-40
25441748-2	2014	Intravenous (IV) iron can rapidly reverse IDA and would be expected to similarly reverse RLS caused by IDA.	Iron	17-21	alpha-L-iduronidase	Homo sapiens	42-45
25441748-2	2014	Intravenous (IV) iron can rapidly reverse IDA and would be expected to similarly reverse RLS caused by IDA.	Iron	17-21	alpha-L-iduronidase	Homo sapiens	103-106
25441748-3	2014	This is the first consecutive case series evaluating the effects of IV iron therapy on RLS occurring with IDA (RLS-IDA).	Iron	71-75	alpha-L-iduronidase	Homo sapiens	106-109
21320535-5	2011	The demonstration of an interaction between gastrin and transferrin by biochemical techniques led to the proposal that gastrins catalyze the loading of transferrin with iron.	Iron	169-173	gastrin	Homo sapiens	44-51
25441748-3	2014	This is the first consecutive case series evaluating the effects of IV iron therapy on RLS occurring with IDA (RLS-IDA).	Iron	71-75	alpha-L-iduronidase	Homo sapiens	111-118
21320535-6	2011	Several lines of evidence, including the facts that the concentrations of circulating gastrins are increased in mice and humans with the iron overload disease hemochromatosis and that transferrin saturation positively correlates with circulating gastrin concentration, suggest the potential involvement of gastrins in iron homeostasis.	Iron	137-141	gastrin	Homo sapiens	86-93
25441748-10	2014	CONCLUSIONS: RLS-IDA is reduced after administration of IV iron in most cases, but the 24% failing to respond was higher than expected.	Iron	59-63	alpha-L-iduronidase	Homo sapiens	13-20
25441748-12	2014	IV iron treatment of the RLS with IDA likely requires ensuring more than minimally adequate body iron stores to support iron delivery to the brain.	Iron	3-7	alpha-L-iduronidase	Homo sapiens	34-37
25441748-13	2014	For some, this may require a dose higher than the customary 1000-mg IV iron used for the treatment of either IDA or RLS alone.	Iron	71-75	alpha-L-iduronidase	Homo sapiens	109-112
21486205-0	2011	Antioxidant enzyme activities of iron-saturated bovine lactoferrin (Fe-bLf) in human gut epithelial cells under oxidative stress.	Iron	33-37	lactotransferrin	Bos taurus	55-66
25204651-6	2014	These results imply a new mechanistic connection between the p38 pathway and mitochondria iron-sulfur clusters.	Iron	90-94	p38a MAP kinase	Drosophila melanogaster	61-64
21486205-2	2011	Recently we reported for the first time that iron content is a critical determinant in the anti-tumour activity of bovine milk lactoferrin (bLf).	Iron	45-49	lactotransferrin	Bos taurus	127-138
25174877-3	2014	Bone morphogenic protein 6 (Bmp6) knockout mice have serum iron overload.	Iron	59-63	bone morphogenetic protein 6	Mus musculus	0-26
21378396-0	2011	Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.	Iron	9-13	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	105-109
21378396-0	2011	Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.	Iron	9-13	thioredoxin	Homo sapiens	110-121
21378396-0	2011	Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.	Iron	9-13	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	141-145
21378396-8	2011	Both iron chelators significantly reduced ASK1-thioredoxin complex formation, resulting in the increased phosphorylation of ASK1, which activates the JNK and p38 pathways.	Iron	5-9	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	42-46
21378396-8	2011	Both iron chelators significantly reduced ASK1-thioredoxin complex formation, resulting in the increased phosphorylation of ASK1, which activates the JNK and p38 pathways.	Iron	5-9	thioredoxin	Homo sapiens	47-58
21378396-8	2011	Both iron chelators significantly reduced ASK1-thioredoxin complex formation, resulting in the increased phosphorylation of ASK1, which activates the JNK and p38 pathways.	Iron	5-9	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	124-128
21378396-9	2011	Thus, dissociation of ASK1 could serve as an important signal for the phosphorylation of JNK and p38 activation observed after iron chelation.	Iron	127-131	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	22-26
25174877-3	2014	Bone morphogenic protein 6 (Bmp6) knockout mice have serum iron overload.	Iron	59-63	bone morphogenetic protein 6	Mus musculus	28-32
25174877-4	2014	Herein, we tested whether the previously documented retinal iron accumulation in Bmp6 knockout mice might result from the high serum iron levels or, alternatively, low levels of retinal hepcidin, an iron regulatory hormone whose transcription can be up-regulated by Bmp6.	Iron	60-64	bone morphogenetic protein 6	Mus musculus	81-85
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	133-137	glutathione S-transferase kappa 1	Homo sapiens	192-217
24718935-2	2014	Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific peptide, controls iron homeostasis.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
21345335-3	2011	Iron overloading of mitochondrial fraction resulted in an increase in lipid peroxidation, protein oxidation, and DNA damage, whereas iron overload reduced the glutathione (GSH) concentration, glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), catalase and superoxide dismutase (SOD) activities.	Iron	133-137	glutathione S-transferase kappa 1	Homo sapiens	219-222
21345335-5	2011	Conversely, naringin supplementation arrested iron-induced depletion in the GSH contents, GSHPx, GST, SOD and catalase activities significantly.	Iron	46-50	glutathione S-transferase kappa 1	Homo sapiens	97-100
21402483-9	2011	Changes in serum indicators in beta-TI patients were associated with altered expressions in PBMCs of hepcidin and IL-1alpha, involved in some way in the regulation of iron homeostasis.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	101-109
24718935-2	2014	Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific peptide, controls iron homeostasis.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	10-14
21402483-9	2011	Changes in serum indicators in beta-TI patients were associated with altered expressions in PBMCs of hepcidin and IL-1alpha, involved in some way in the regulation of iron homeostasis.	Iron	167-171	interleukin 1 alpha	Homo sapiens	114-123
25093806-2	2014	Burgeoning evidence indicates that the central signaling of iron homeostasis, the hepcidin-ferroportin axis, is misregulated in cancers.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	82-90
21276595-9	2011	CONCLUSIONS: Our findings support an implication for iron metabolism in ALS and suggest that the genotype of the SLC11A2 gene could modulate the duration of the disease in French SALS patients.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	113-120
25093806-6	2014	Mechanistic investigation revealed that increased iron, bone morphogenetic protein-6 (BMP6) and interleukin-6 (IL-6) jointly promoted the synthesis of hepatic hepcidin.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	159-167
25262081-0	2014	SERS active Ag encapsulated Fe@SiO2 nanorods in electromagnetic wave absorption and crystal violet detection.	Iron	28-30	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
21289291-1	2011	Hepcidin negatively regulates systemic iron homeostasis in response to inflammation and elevated serum iron.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
21289291-1	2011	Hepcidin negatively regulates systemic iron homeostasis in response to inflammation and elevated serum iron.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	0-8
21292994-7	2011	When challenged with the high-iron diet, Bmp6 and Hfe expression was significantly increased.	Iron	30-34	bone morphogenetic protein 6	Mus musculus	41-45
25262081-8	2014	The synthesized Ag encapsulated Fe@SiO2 nanostructure also exhibited the SERS phenomena, which is useful in the detection of the carcinogenic dye crystal violet (CV) upto the concentration of 10(-10)M. All these findings clearly demonstrate that the Ag encapsulated Fe@SiO2 nanostructure could efficiently be used in the environmental remediation.	Iron	32-34	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	73-77
25262081-8	2014	The synthesized Ag encapsulated Fe@SiO2 nanostructure also exhibited the SERS phenomena, which is useful in the detection of the carcinogenic dye crystal violet (CV) upto the concentration of 10(-10)M. All these findings clearly demonstrate that the Ag encapsulated Fe@SiO2 nanostructure could efficiently be used in the environmental remediation.	Iron	266-268	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	73-77
25130273-5	2014	Furthermore,  opt2 strains display synthetic lethality with deletions of genes central to iron homeostasis that require mitochondrial glutathione redox homeostasis.	Iron	90-94	Opt2p	Saccharomyces cerevisiae S288C	14-18
21544718-7	2011	Heme oxygenase-1 is considered to be an antioxidant enzyme that catabolizes heme to carbon monoxide, free iron and biliverdin, while SIRT1 is the mammalian homologue of the yeast silent information regulator (Sir)-2, which are involved in the suppression of inflammatory mediators or factors that may be used to improve atopy-related symptoms.	Iron	106-110	heme oxygenase 1	Homo sapiens	0-16
21029774-5	2011	We show here the facile assembly of Mt-FTL and FTH1 subunits into soluble ferritin heteropolymers, but their ability to incorporate iron was significantly reduced relative to Wt-FTL/FTH1 heteropolymers.	Iron	132-136	ferritin heavy chain 1	Homo sapiens	47-51
21029774-6	2011	In addition, Mt-FTL/FTH1 heteropolymers formed aggregates during iron loading, contrasting Wt-FTL/FTH1 heteropolymers and similar to what was seen for Mt-FTL homopolymers.	Iron	65-69	ferritin heavy chain 1	Homo sapiens	20-24
25168891-8	2014	Second, CLIC5 rs3734207 and rs11752816 polymorphisms (regulatory region) to the 2 iron, 2 sulfur cluster binding pathway through regulating expression levels of CLIC5 mRNA.	Iron	82-86	chloride intracellular channel 5	Homo sapiens	8-13
21229381-6	2011	Antibody to TIMP-2 immunoprecipitated 74% of the ferrozine detectable iron in its protein fraction.	Iron	70-74	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	12-18
25168891-8	2014	Second, CLIC5 rs3734207 and rs11752816 polymorphisms (regulatory region) to the 2 iron, 2 sulfur cluster binding pathway through regulating expression levels of CLIC5 mRNA.	Iron	82-86	chloride intracellular channel 5	Homo sapiens	161-166
21229381-7	2011	TIMP-2 binds iron in vitro at pH 6.3, which is typical of conditions in the mesentery during hemorrhage, but it retains the ability to inhibit the metalloproteases MMP-2 and MMP-9.	Iron	13-17	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	0-6
21229381-9	2011	We have identified, for the first time, the binding of extracellular iron to TIMP-2.	Iron	69-73	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	77-83
25484411-3	2014	Hepcidin is an important and recently discovered regulator of iron homeostasis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
21332711-2	2011	We evaluated changes in serum hepcidin during 3 months of therapy with the iron-chelator deferasirox in patients with low-risk myelodysplastic syndrome and iron overload.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	30-38
21332711-2	2011	We evaluated changes in serum hepcidin during 3 months of therapy with the iron-chelator deferasirox in patients with low-risk myelodysplastic syndrome and iron overload.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	30-38
25484411-8	2014	CONCLUSIONS: We think that studies on hepcidin expression in psoriatic plaques will contribute to our understanding the role of iron and hepcidin in the pathogenesis of psoriasis.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	38-46
21332711-3	2011	Serum hepcidin was found to be high in these patients, correlated with their iron and oxidative status, and further increased by treatment with deferasirox.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	6-14
21332711-4	2011	These findings support the concept that the hepcidin level represents a balance between the stimulating effect of iron overload and the inhibitory effects of erythropoietic activity and oxidative stress.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	44-52
25267320-2	2014	Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and directs iron towards deposits and the recently discovered erythroblast-derived erythroferrone which inhibits hepcidin synthesis and therefore increases availability of iron for hemoglobin synthesis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	113-121
21499539-5	2011	This review summarizes some key structural and functional properties of three central proteins dedicated to the Fe-S cluster assembly process: namely, the sulfide donor (cysteine desulfurase); iron donor (frataxin), and the iron-sulfur cluster scaffold protein (IscU/ISU).	Iron	112-116	NFU1 iron-sulfur cluster scaffold	Homo sapiens	224-260
25267320-2	2014	Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and directs iron towards deposits and the recently discovered erythroblast-derived erythroferrone which inhibits hepcidin synthesis and therefore increases availability of iron for hemoglobin synthesis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	264-272
21173098-0	2011	A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	17-25
21173098-1	2011	BACKGROUND: Inadequate hepcidin production leads to iron overload in nearly all types of hemochromatosis.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	23-31
25267320-2	2014	Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and directs iron towards deposits and the recently discovered erythroblast-derived erythroferrone which inhibits hepcidin synthesis and therefore increases availability of iron for hemoglobin synthesis.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	113-121
21173098-2	2011	We explored the acute response of hepcidin to iron challenge in 25 patients with HFE-hemochromatosis, in two with TFR2-hemochromatosis and in 13 controls.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	34-42
21173098-7	2011	The hepcidin response was smaller in C282Y-homozygotes than in controls, barely detectable in the patients with iron-depleted HFE-hemochromatosis and absent in those with TFR2-hemochromatosis.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	4-12
21173098-8	2011	Conclusions Our results are consistent with a scenario in which TFR2 plays a prominent and HFE a contributory role in the hepcidin response to a dose of oral iron.	Iron	158-162	transferrin receptor 2	Homo sapiens	64-68
25267320-2	2014	Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and directs iron towards deposits and the recently discovered erythroblast-derived erythroferrone which inhibits hepcidin synthesis and therefore increases availability of iron for hemoglobin synthesis.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	113-121
25267320-2	2014	Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and directs iron towards deposits and the recently discovered erythroblast-derived erythroferrone which inhibits hepcidin synthesis and therefore increases availability of iron for hemoglobin synthesis.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	113-121
25267320-5	2014	Additionally, infectious episodes and other inflammatory conditions that often complicate the course of these diseases may further promote hepcidin synthesis through increased cytokine production leading to even lower iron availability and a vicious circle of worsening anemia.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	139-147
21480335-6	2011	BMP6, whose expression is also regulated by iron, may mediate hepcidin regulation by iron stores.	Iron	44-48	bone morphogenetic protein 6	Mus musculus	0-4
21480335-6	2011	BMP6, whose expression is also regulated by iron, may mediate hepcidin regulation by iron stores.	Iron	85-89	bone morphogenetic protein 6	Mus musculus	0-4
25207938-7	2014	For example, histone deacetylase 8 naturally operates with Zn(2+) in the active site but becomes much more active with Fe(2+).	Iron	119-121	histone deacetylase 8	Homo sapiens	13-34
21480335-8	2011	CONCLUSION: TfR2, HJV, BMP6, and, to a lesser extent, HFE are required for the hepcidin response to acute iron loading, but are partially redundant for hepcidin regulation during chronic iron loading and are not involved in the regulation of BMP6 expression.	Iron	106-110	bone morphogenetic protein 6	Mus musculus	23-27
21766512-6	2011	The correlation coefficient (R) between the values of iron-containing substances and pHp were low (R=0.244).	Iron	54-58	N-acylsphingosine amidohydrolase 1	Homo sapiens	85-88
25330009-2	2014	Accumulating evidence indicates that chronic HCV infection suppresses expression of hepatic hepcidin, a key mediator of iron homeostasis, leading to iron overload conditions.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	92-100
21766512-8	2011	CONCLUSION: Because of low correlation between sFe and pHp, it seems more likely that the positive two-month change of iron-containing substances in the serum of the studied patients is a result of treatment, impaired liver function or malignant intoxication, rather than of decreased pHp.	Iron	119-123	N-acylsphingosine amidohydrolase 1	Homo sapiens	55-58
21766512-8	2011	CONCLUSION: Because of low correlation between sFe and pHp, it seems more likely that the positive two-month change of iron-containing substances in the serum of the studied patients is a result of treatment, impaired liver function or malignant intoxication, rather than of decreased pHp.	Iron	119-123	N-acylsphingosine amidohydrolase 1	Homo sapiens	285-288
25330009-2	2014	Accumulating evidence indicates that chronic HCV infection suppresses expression of hepatic hepcidin, a key mediator of iron homeostasis, leading to iron overload conditions.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	92-100
21364282-6	2011	These data help to explain the increased Hamp mRNA levels and subsequent iron deficiency in mice with reduced miR-122 levels and establish a direct mechanistic link between miR-122 and the regulation of systemic iron metabolism.	Iron	73-77	microRNA 122	Mus musculus	110-117
25330009-5	2014	The expression of duodenal Fpn1 is negatively correlated with mRNA levels of hepcidin, and positively correlated with serum iron parameters.	Iron	124-128	solute carrier family 40 member 1	Homo sapiens	27-31
25012650-3	2014	Here we show that Fe-S assembly of mitoNEET, the first identified Fe-S protein anchored in the mitochondrial outer membrane, strictly depends on ISC machineries and not on the CIA or CIAPIN1.	Iron	18-22	CDGSH iron sulfur domain 1	Homo sapiens	35-43
20383623-0	2011	Oxidative stress partially contributes to iron-induced alpha-synuclein aggregation in SK-N-SH cells.	Iron	42-46	synuclein alpha	Homo sapiens	55-70
20383623-2	2011	As its main component, aggregated alpha-synuclein is presented in the substantia nigra, the same region iron accumulation occurs.	Iron	104-108	synuclein alpha	Homo sapiens	34-49
25012650-3	2014	Here we show that Fe-S assembly of mitoNEET, the first identified Fe-S protein anchored in the mitochondrial outer membrane, strictly depends on ISC machineries and not on the CIA or CIAPIN1.	Iron	18-20	CDGSH iron sulfur domain 1	Homo sapiens	35-43
20383623-3	2011	In this study, the relationship between iron and alpha-synuclein aggregation was investigated.	Iron	40-44	synuclein alpha	Homo sapiens	49-64
20383623-7	2011	Due to the predicted iron responsive element (IRE) in the 5"-untranslated region of the human alpha-synuclein mRNA contains, we observed that alpha-synuclein mRNA level was up-regulated in SK-N-SH cells with iron regulatory protein (IRP) knockdown and more alpha-synuclein aggregations were observed in cells.	Iron	21-25	synuclein alpha	Homo sapiens	94-109
25012650-5	2014	When inserted, the Fe-S cluster confers mitoNEET folding and stability in vitro and in vivo.	Iron	19-23	CDGSH iron sulfur domain 1	Homo sapiens	40-48
20383623-7	2011	Due to the predicted iron responsive element (IRE) in the 5"-untranslated region of the human alpha-synuclein mRNA contains, we observed that alpha-synuclein mRNA level was up-regulated in SK-N-SH cells with iron regulatory protein (IRP) knockdown and more alpha-synuclein aggregations were observed in cells.	Iron	21-25	synuclein alpha	Homo sapiens	142-157
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	102-106	CDGSH iron sulfur domain 1	Homo sapiens	17-25
20383623-7	2011	Due to the predicted iron responsive element (IRE) in the 5"-untranslated region of the human alpha-synuclein mRNA contains, we observed that alpha-synuclein mRNA level was up-regulated in SK-N-SH cells with iron regulatory protein (IRP) knockdown and more alpha-synuclein aggregations were observed in cells.	Iron	21-25	synuclein alpha	Homo sapiens	142-157
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	110-114	CDGSH iron sulfur domain 1	Homo sapiens	17-25
20383623-8	2011	The results suggest that iron-induced intracellular aggregated alpha-synuclein is partially dependent on oxidative stress and iron might also regulate alpha-synuclein aggregation through the IRE/IRP system.	Iron	25-29	synuclein alpha	Homo sapiens	63-78
20383623-8	2011	The results suggest that iron-induced intracellular aggregated alpha-synuclein is partially dependent on oxidative stress and iron might also regulate alpha-synuclein aggregation through the IRE/IRP system.	Iron	25-29	synuclein alpha	Homo sapiens	151-166
20383623-8	2011	The results suggest that iron-induced intracellular aggregated alpha-synuclein is partially dependent on oxidative stress and iron might also regulate alpha-synuclein aggregation through the IRE/IRP system.	Iron	126-130	synuclein alpha	Homo sapiens	151-166
25012650-6	2014	The holo-form of mitoNEET is resistant to NO and H2O2 and is capable of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of cellular iron that has recently been involved in the mitochondrial iron supply.	Iron	175-179	CDGSH iron sulfur domain 1	Homo sapiens	17-25
25012650-7	2014	Therefore, our findings point to IRP1 as the missing link to explain the function of mitoNEET in the control of mitochondrial iron homeostasis.	Iron	126-130	CDGSH iron sulfur domain 1	Homo sapiens	85-93
21422745-6	2011	Transferrin and TFR2 are important in iron homeostasis.	Iron	38-42	transferrin receptor 2	Homo sapiens	16-20
24966132-1	2014	Copper-containing plasma protein ceruloplasmin (Cp) forms a complex with lactoferrin (Lf), an iron-binding protein, and with the heme-containing myeloperoxidase (Mpo).	Iron	94-98	ceruloplasmin	Homo sapiens	33-46
21518504-1	2011	The aim of this study was to investigate the expression of transferrin receptor 2 (TfR2) mRNA in bone marrow mononuclear cells (BMMNC) of children with hyperplastic anemia (HA), to analyze the correlation of TfR2 mRNA expression level with Hb level, bone marrow erythroid hyperplasia, iron status in body and underlying diseases, and to evaluate the role of TfR2 in erythroid hemopoiesis and the useful value in diagnosis of HA.	Iron	285-289	transferrin receptor 2	Homo sapiens	59-81
21518504-1	2011	The aim of this study was to investigate the expression of transferrin receptor 2 (TfR2) mRNA in bone marrow mononuclear cells (BMMNC) of children with hyperplastic anemia (HA), to analyze the correlation of TfR2 mRNA expression level with Hb level, bone marrow erythroid hyperplasia, iron status in body and underlying diseases, and to evaluate the role of TfR2 in erythroid hemopoiesis and the useful value in diagnosis of HA.	Iron	285-289	transferrin receptor 2	Homo sapiens	83-87
25043284-2	2014	In the present study, we determined by radioimmunoassay the levels of hepcidin, a key regulator of iron homeostasis, in sera of 182 women infected with HIV-1 under highly active antiretroviral therapy (HAART).	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	70-78
21518525-4	2011	Subsequently, low hepcidin levels increase iron absorption from the intestine resulting in iron overload.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	18-26
21518525-4	2011	Subsequently, low hepcidin levels increase iron absorption from the intestine resulting in iron overload.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	18-26
25043284-4	2014	Serum hepcidin concentrations were strongly correlated positively with iron, ferritin, urea, and uric acid.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	6-14
21439478-0	2011	Understanding the structure/activity relationships of the iron regulatory peptide hepcidin.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	82-90
21439478-1	2011	The peptide hormone hepcidin is a key homeostatic regulator of iron metabolism and involved in pathological regulation of iron in response to infection, inflammation, hypoxia, and anemia.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	20-28
25043284-8	2014	This study suggests that hepcidin controls serum iron, especially in response of iron utilization by HIV for viral replication.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	25-33
21439478-1	2011	The peptide hormone hepcidin is a key homeostatic regulator of iron metabolism and involved in pathological regulation of iron in response to infection, inflammation, hypoxia, and anemia.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	20-28
21439478-5	2011	These results identify important constraints for the development of hepcidin congeners for the treatment of hereditary iron overload.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	68-76
25043284-8	2014	This study suggests that hepcidin controls serum iron, especially in response of iron utilization by HIV for viral replication.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	25-33
25247888-2	2014	When there is a lack of ceruloplasmin ferroxidase activity, iron accumulates, especially in the brain, pancreas, liver, and retina.	Iron	60-64	ceruloplasmin	Homo sapiens	24-49
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	39-43	heme oxygenase 1	Homo sapiens	126-142
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	206-210	ceruloplasmin	Homo sapiens	107-120
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	206-210	heme oxygenase 1	Homo sapiens	126-142
21208937-0	2011	Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.	Iron	104-108	transferrin receptor 2	Homo sapiens	42-46
21208937-3	2011	We identified and replicated a novel association of a common variant in the type-2 transferrin receptor (TFR2) gene with iron levels, with effect sizes highly consistent across samples.	Iron	121-125	transferrin receptor 2	Homo sapiens	105-109
21208937-7	2011	These functional findings require confirmation in further studies with larger sample sizes, but they suggest that common variants in TMPRSS6 could modify the hepcidin-iron feedback loop in clinically unaffected individuals, thus making them more susceptible to imbalances of iron homeostasis.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	158-166
21208937-7	2011	These functional findings require confirmation in further studies with larger sample sizes, but they suggest that common variants in TMPRSS6 could modify the hepcidin-iron feedback loop in clinically unaffected individuals, thus making them more susceptible to imbalances of iron homeostasis.	Iron	275-279	hepcidin antimicrobial peptide	Homo sapiens	158-166
25066791-7	2014	It is distinguished from the copper structurally bound to the ceruloplasmin protein, a master protein of iron metabolism.	Iron	105-109	ceruloplasmin	Homo sapiens	62-75
21175851-8	2011	The patient presented a mild iron overload phenotype probably because of the two novel mutations in the HFE and SLC40A1 genes.	Iron	29-33	solute carrier family 40 member 1	Homo sapiens	112-119
21285884-2	2011	Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	25-33
24863668-3	2014	In both systems, we observed iron-induced disruptions of amyloid precursor protein (APP) processing, neuronal signaling, and cognitive behavior.	Iron	29-33	amyloid beta (A4) precursor protein	Mus musculus	57-82
24863668-6	2014	Calcium imaging confirmed that 24 hours iron exposure led to disrupted synaptic signaling by augmenting GluN2B-containing NMDAR expression-GluN2B messenger RNA and protein levels were increased and promoting excessing extrasynaptic NMDAR signaling.	Iron	40-44	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	104-110
20701626-0	2011	Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-alpha and ERK activation.	Iron	0-4	matrix metallopeptidase 1	Homo sapiens	62-88
20701626-6	2011	However, the iron-exposed fibroblasts were sensitized to UVA exposure, which resulted in a synergistic increase in MMP-1.	Iron	13-17	matrix metallopeptidase 1	Homo sapiens	115-120
24863668-6	2014	Calcium imaging confirmed that 24 hours iron exposure led to disrupted synaptic signaling by augmenting GluN2B-containing NMDAR expression-GluN2B messenger RNA and protein levels were increased and promoting excessing extrasynaptic NMDAR signaling.	Iron	40-44	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	122-127
20701626-10	2011	Our results indicate that iron and UVA increase MMP-1 activity in dermal fibroblasts not only directly through ERK activation but also by an indirect paracrine loop through TNF-alpha released by NHEK.	Iron	26-30	matrix metallopeptidase 1	Homo sapiens	48-53
24863668-6	2014	Calcium imaging confirmed that 24 hours iron exposure led to disrupted synaptic signaling by augmenting GluN2B-containing NMDAR expression-GluN2B messenger RNA and protein levels were increased and promoting excessing extrasynaptic NMDAR signaling.	Iron	40-44	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	139-145
24863668-6	2014	Calcium imaging confirmed that 24 hours iron exposure led to disrupted synaptic signaling by augmenting GluN2B-containing NMDAR expression-GluN2B messenger RNA and protein levels were increased and promoting excessing extrasynaptic NMDAR signaling.	Iron	40-44	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	232-237
24863668-8	2014	In APP/PS1 mice, chronic iron treatment led to hastened progression of cognitive impairment with the novel object recognition discrimination index, revealing a deficit at the age of 4 months, concomitant with augmented GluN2B expression.	Iron	25-29	presenilin 1	Mus musculus	7-10
24863668-8	2014	In APP/PS1 mice, chronic iron treatment led to hastened progression of cognitive impairment with the novel object recognition discrimination index, revealing a deficit at the age of 4 months, concomitant with augmented GluN2B expression.	Iron	25-29	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	219-225
20563825-3	2011	Astroglial induction of the Hmox1 gene by beta-amyloid, pro-inflammatory cytokines and hydrogen peroxide promotes mitochondrial sequestration of non-transferrin iron and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergy failure amply documented in AD-affected neural tissues.	Iron	161-165	heme oxygenase 1	Homo sapiens	28-33
24863668-9	2014	Together, these data suggest iron-induced APP misprocessing and hastened cognitive decline occur through inordinate extrasynaptic NMDAR activation.	Iron	29-33	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	130-135
20563825-3	2011	Astroglial induction of the Hmox1 gene by beta-amyloid, pro-inflammatory cytokines and hydrogen peroxide promotes mitochondrial sequestration of non-transferrin iron and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergy failure amply documented in AD-affected neural tissues.	Iron	232-236	heme oxygenase 1	Homo sapiens	28-33
25194615-14	2014	However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	31-39
20563825-5	2011	Suppression of glial HO-1 activity by pharmacological or other means may confer neuroprotection in AD by curtailing iron-mediated neurotoxicity.	Iron	116-120	heme oxygenase 1	Homo sapiens	21-25
24128336-10	2014	Fe and vitamin A status were significantly different between the IDA and non-IDA groups and also based on their inflammation status.	Iron	0-2	alpha-L-iduronidase	Homo sapiens	65-68
20690031-6	2011	However, while silencing the expression of alpha-synuclein in SK-N-SH cells with siRNA, iron-induced toxicity could be partially alleviated, indicated by the returned Deltapsi(m) and cell viability and reduced ROS formation compared with that of control.	Iron	88-92	synuclein alpha	Homo sapiens	43-58
20690031-8	2011	The results suggest that alpha-synuclein aggregation was involved in the toxicity of iron to SK-N-SH neuroblastoma cells.	Iron	85-89	synuclein alpha	Homo sapiens	25-40
20809066-2	2011	A broad overview of iron metabolism and its homeostasis both at the cellular level (involving regulation at the level of mRNA translation) and the systemic level (involving the peptide "hormone" hepcidin) is presented.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	195-203
24128336-10	2014	Fe and vitamin A status were significantly different between the IDA and non-IDA groups and also based on their inflammation status.	Iron	0-2	alpha-L-iduronidase	Homo sapiens	77-80
24128336-12	2014	ANOVA showed that better Fe status was associated with a higher concentration of serum retinol but only in IDA.	Iron	25-27	alpha-L-iduronidase	Homo sapiens	107-110
25233197-1	2014	This study reports increasing iron concentrations in rivers draining into the Baltic Sea.	Iron	30-34	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
21221670-2	2011	Dopaminergic neurons exhibit elevated iron levels that can accelerate toxic SNCA fibril formation.	Iron	38-42	synuclein alpha	Homo sapiens	76-80
21221670-9	2011	For Posiphen this inhibition was accelerated in the presence of iron, thus providing a known APP-directed lead with potential for use as a SNCA blocker for PD therapy.	Iron	64-68	synuclein alpha	Homo sapiens	139-143
20826742-8	2011	In parallel, intravenous iron injection resulted in storage of the metal in circulating monocytes as reflected by an increase of intracellular ferritin levels, and the amount of iron retention was positively associated with circulating concentrations of the iron regulatory peptide hepcidin.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	282-290
24957529-6	2014	During the past 10 years, knowledge about the transport, storage and homeostasis of iron has improved dramatically, and new molecules involved in iron metabolism have been described (eg, hepcidin, ferroportin, divalent metal transporter 1).	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	187-195
20826742-8	2011	In parallel, intravenous iron injection resulted in storage of the metal in circulating monocytes as reflected by an increase of intracellular ferritin levels, and the amount of iron retention was positively associated with circulating concentrations of the iron regulatory peptide hepcidin.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	282-290
20826742-8	2011	In parallel, intravenous iron injection resulted in storage of the metal in circulating monocytes as reflected by an increase of intracellular ferritin levels, and the amount of iron retention was positively associated with circulating concentrations of the iron regulatory peptide hepcidin.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	282-290
20826742-11	2011	In addition, circulating hepcidin concentrations may determine the erythropoietic response to iron injection by modifying iron retention within monocytes.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	25-33
20826742-11	2011	In addition, circulating hepcidin concentrations may determine the erythropoietic response to iron injection by modifying iron retention within monocytes.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	25-33
25089007-8	2014	SIGNIFICANCE: Iron, nickel, cobalt and cadmium act as inhibitors of mZIP1, the affinity order being iron&gt;zinc&gt;nickel=cadmium&gt;cobalt, and copper might also act as an inhibitor, while manganese and magnesium are not recognized by mZIP1.	Iron	14-18	solute carrier family 39 (zinc transporter), member 1	Mus musculus	68-73
25089007-8	2014	SIGNIFICANCE: Iron, nickel, cobalt and cadmium act as inhibitors of mZIP1, the affinity order being iron&gt;zinc&gt;nickel=cadmium&gt;cobalt, and copper might also act as an inhibitor, while manganese and magnesium are not recognized by mZIP1.	Iron	14-18	solute carrier family 39 (zinc transporter), member 1	Mus musculus	237-242
25089007-8	2014	SIGNIFICANCE: Iron, nickel, cobalt and cadmium act as inhibitors of mZIP1, the affinity order being iron&gt;zinc&gt;nickel=cadmium&gt;cobalt, and copper might also act as an inhibitor, while manganese and magnesium are not recognized by mZIP1.	Iron	100-104	solute carrier family 39 (zinc transporter), member 1	Mus musculus	68-73
25152992-1	2014	BACKGROUND &amp; AIMS: Juvenile hemochromatosis (JH) is a rare autosomal recessive disorder characterized by severe early-onset iron overload, caused by mutations in hemojuvelin (HJV), hepcidin (HAMP), or a combination of genes regulating iron metabolism.	Iron	128-132	hemojuvelin BMP co-receptor	Homo sapiens	166-177
25152992-1	2014	BACKGROUND &amp; AIMS: Juvenile hemochromatosis (JH) is a rare autosomal recessive disorder characterized by severe early-onset iron overload, caused by mutations in hemojuvelin (HJV), hepcidin (HAMP), or a combination of genes regulating iron metabolism.	Iron	239-243	hemojuvelin BMP co-receptor	Homo sapiens	179-182
25152992-6	2014	RESULTS: In case 1, we detected heterozygosity for a novel HJV mutation (g.3659_3660insG), which was inherited together with the beta thalassemia trait from the father, who (as well as the mother) had normal iron parameters.	Iron	208-212	hemojuvelin BMP co-receptor	Homo sapiens	59-62
24859227-7	2014	This indicates that intact iron export might be necessary for hepcidin-induced downregulation of ferroportin.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	62-70
24859227-8	2014	This hypothesis was investigated by studying the hepcidin response under modulation of iron availability.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	49-57
24859227-9	2014	Incubation of wild-type ferroportin overexpressing cells with holo-transferrin increases the hepcidin effect whereas chelating extracellular ferrous iron causes hepcidin resistance.	Iron	141-153	hepcidin antimicrobial peptide	Homo sapiens	161-169
24859227-10	2014	In this study we present data that postulates to classify the D181V ferroportin mutation as loss of function and the A69T mutation as dose-dependent hepcidin resistant and outline a possible causal link between iron export function and the hepcidin effect.	Iron	211-215	hepcidin antimicrobial peptide	Homo sapiens	149-157
24859227-10	2014	In this study we present data that postulates to classify the D181V ferroportin mutation as loss of function and the A69T mutation as dose-dependent hepcidin resistant and outline a possible causal link between iron export function and the hepcidin effect.	Iron	211-215	hepcidin antimicrobial peptide	Homo sapiens	240-248
24568186-8	2014	We speculated that iron, a by-product of HO-1-catalyzed reactions, could mediate 15d-PGJ2-induced p53 expression.	Iron	19-23	heme oxygenase 1	Homo sapiens	41-45
24568186-10	2014	Iron released from heme by HO-1 activity is mostly in the Fe(2+) form.	Iron	0-4	heme oxygenase 1	Homo sapiens	27-31
24568186-13	2014	In conclusion, upregulation of p53 and p21 via HO-1 induction and subsequent release of iron with accumulation of H-ferritin may confer resistance to oxidative damage in cancer cells frequently challenged by redox-cycling anticancer drugs.	Iron	88-92	H3 histone pseudogene 16	Homo sapiens	39-42
24895335-3	2014	Serum concentrations of hepcidin, a key regulator of iron homeostasis, are increased in patients with anemia of chronic disease and linked to the pathogenesis of this disease, because hepcidin blocks cellular iron egress, thus limiting availability of iron for erythropoiesis.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	24-32
24895335-3	2014	Serum concentrations of hepcidin, a key regulator of iron homeostasis, are increased in patients with anemia of chronic disease and linked to the pathogenesis of this disease, because hepcidin blocks cellular iron egress, thus limiting availability of iron for erythropoiesis.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	184-192
24895335-3	2014	Serum concentrations of hepcidin, a key regulator of iron homeostasis, are increased in patients with anemia of chronic disease and linked to the pathogenesis of this disease, because hepcidin blocks cellular iron egress, thus limiting availability of iron for erythropoiesis.	Iron	209-213	hepcidin antimicrobial peptide	Homo sapiens	24-32
24895335-3	2014	Serum concentrations of hepcidin, a key regulator of iron homeostasis, are increased in patients with anemia of chronic disease and linked to the pathogenesis of this disease, because hepcidin blocks cellular iron egress, thus limiting availability of iron for erythropoiesis.	Iron	209-213	hepcidin antimicrobial peptide	Homo sapiens	184-192
24895335-3	2014	Serum concentrations of hepcidin, a key regulator of iron homeostasis, are increased in patients with anemia of chronic disease and linked to the pathogenesis of this disease, because hepcidin blocks cellular iron egress, thus limiting availability of iron for erythropoiesis.	Iron	209-213	hepcidin antimicrobial peptide	Homo sapiens	24-32
24895335-3	2014	Serum concentrations of hepcidin, a key regulator of iron homeostasis, are increased in patients with anemia of chronic disease and linked to the pathogenesis of this disease, because hepcidin blocks cellular iron egress, thus limiting availability of iron for erythropoiesis.	Iron	209-213	hepcidin antimicrobial peptide	Homo sapiens	184-192
24332775-7	2014	RESULTS: We observed increased expression of IGF-II, along with a corresponding decrease in the expression of IGF-IIR, in iron-deficient mixed primary cell cultures.	Iron	122-126	insulin like growth factor 2	Homo sapiens	45-51
24332775-10	2014	CONCLUSIONS: In vitro iron deficiency increases the expression of IGF-II in mixed glial cell cultures, which may have a beneficial effect on brain tissue homeostasis in a situation in which iron availability is decreased.	Iron	22-26	insulin like growth factor 2	Homo sapiens	66-72
25153171-6	2014	MD simulations show that ibuprofen and warfarin association to the secondary fatty acid (FA) binding site 2 (FA2) induces a reorientation of domain I of HSA-heme-Fe(III), this leads to the redirection of the His146 residue providing an additional bond to the heme-Fe(III) atom, providing the 5+1 configuration.	Iron	162-164	FA complementation group B	Homo sapiens	109-112
24854545-1	2014	DMT1 (divalent metal transporter 1) is the main iron importer found in animals, and ferrous iron is taken up by cells via DMT1.	Iron	48-52	solute carrier family 11 member 2	Homo sapiens	0-4
24854545-1	2014	DMT1 (divalent metal transporter 1) is the main iron importer found in animals, and ferrous iron is taken up by cells via DMT1.	Iron	48-52	solute carrier family 11 member 2	Homo sapiens	6-34
24854545-1	2014	DMT1 (divalent metal transporter 1) is the main iron importer found in animals, and ferrous iron is taken up by cells via DMT1.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	0-4
24854545-1	2014	DMT1 (divalent metal transporter 1) is the main iron importer found in animals, and ferrous iron is taken up by cells via DMT1.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	6-34
24854545-1	2014	DMT1 (divalent metal transporter 1) is the main iron importer found in animals, and ferrous iron is taken up by cells via DMT1.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	122-126
24854545-7	2014	Iron uptake and subsequent ferritin expression were suppressed by either DMT1 or PCBP2 knockdown.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	73-77
24854545-8	2014	Iron-associated DMT1 could interact with PCBP2 in vitro, whereas iron-chelated DMT1 could not.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	16-20
24923296-5	2014	Renewed interest in the iron field was heralded by the discovery of hepcidin, the main serum peptide hormone negative regulator of body iron.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	68-76
24923296-5	2014	Renewed interest in the iron field was heralded by the discovery of hepcidin, the main serum peptide hormone negative regulator of body iron.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	68-76
24923296-6	2014	Evidence from beta-thalassemia suggests that regulation of hepcidin by erythropoiesis dominates regulation by iron.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	59-67
24923296-7	2014	Because iron overload develops in some MDS patients who do not require RBC transfusions, the suppressive effect of ineffective erythropoiesis on hepcidin may also play a role in iron overload.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	145-153
24971490-6	2014	Additional mutagenesis, enzyme kinetic, UV-visible, and circular dichroism spectroscopic studies suggest conserved ISCU2 residue C104 is critical for FXN activation, whereas C35, C61, and C104 are all essential for Fe-S cluster formation on the assembly complex.	Iron	215-219	migration and invasion enhancer 1	Homo sapiens	174-177
25093277-1	2014	Hepcidin is the master regulator of systemic iron bioavailability in humans.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
25093277-2	2014	This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth outcomes; areas for future research are also discussed.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	61-69
25093277-4	2014	Collectively, the results indicate that hepcidin is lower during pregnancy than in a non-pregnant state, presumably to ensure greater iron bioavailability to the mother and fetus.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	40-48
25093277-5	2014	Pregnant women with undetectable serum hepcidin transferred a greater quantity of maternally ingested iron to their fetus compared to women with detectable hepcidin, indicating that maternal hepcidin in part determines the iron bioavailability to the fetus.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	39-47
25093277-6	2014	However, inflammatory states, including preeclampsia, malaria infection, and obesity were associated with higher hepcidin during pregnancy compared to healthy controls, suggesting that maternal and fetal iron bioavailability could be compromised in such conditions.	Iron	204-208	hepcidin antimicrobial peptide	Homo sapiens	113-121
25093277-7	2014	Future studies should examine the relative contribution of maternal versus fetal hepcidin to the control of placental iron transfer as well as optimizing maternal and fetal iron bioavailability in pregnancies complicated by inflammation.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	81-89
27790001-2	2011	For example, it stimulates the production of acute-phase reactants (C-reactive protein and serum amyloid A) and hepcidin which interferes with iron recycling and absorption, causing iron-deficient anemia, and augments expression of vascular endothelial growth factor and receptor activator of nuclear factor-kappaB ligand in synovial cells, leading to neovascularization and osteoclast formation.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	112-120
24933511-0	2014	The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis.	Iron	37-41	lactotransferrin	Bos taurus	59-70
21147772-1	2011	We have previously shown that overexpressing subunits of the iron-binding protein ferritin can rescue the toxicity of the amyloid beta (Abeta) peptide in our Drosophila model system.	Iron	61-65	Ferritin 2 light chain homologue	Drosophila melanogaster	82-90
21147772-1	2011	We have previously shown that overexpressing subunits of the iron-binding protein ferritin can rescue the toxicity of the amyloid beta (Abeta) peptide in our Drosophila model system.	Iron	61-65	beta amyloid protein precursor-like	Drosophila melanogaster	136-141
24628561-9	2014	Microarray and quantitative RT-PCR analyses on the bone marrow stromal cells demonstrated remarkably reduced expression of CXCL12, VCAM-1, Kit-ligand, and IGF-1 in the iron-overloaded mice.	Iron	168-172	vascular cell adhesion molecule 1	Mus musculus	131-137
21147772-3	2011	In this study, we have used an iron-selective chelating compound and RNAi-mediated knockdown of endogenous ferritin to further manipulate iron in the brain.	Iron	138-142	Ferritin 2 light chain homologue	Drosophila melanogaster	107-115
21147772-4	2011	We confirm that chelation of iron protects the fly from the harmful effects of Abeta.	Iron	29-33	beta amyloid protein precursor-like	Drosophila melanogaster	79-84
21147772-6	2011	We find that iron slows the progression of the Abeta peptide from an unstructured conformation to the ordered cross-beta fibrils that are characteristic of amyloid.	Iron	13-17	beta amyloid protein precursor-like	Drosophila melanogaster	47-52
21219868-0	2011	Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	13-21
24628561-9	2014	Microarray and quantitative RT-PCR analyses on the bone marrow stromal cells demonstrated remarkably reduced expression of CXCL12, VCAM-1, Kit-ligand, and IGF-1 in the iron-overloaded mice.	Iron	168-172	kit ligand	Mus musculus	139-149
24880481-3	2014	While replacement therapy may be beneficial, dietary iron absorption is impaired in PAH patients by hepcidin, a key regulatory protein of iron homoeostasis.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	100-108
20390345-7	2011	The up-regulation of ferritin light chain and ferritin heavy chain in MDA-MB-231 cells was accompanied by alterations in the subcellular distribution of these proteins as characterized by an increased level of nuclear ferritin and a lower level of the cellular labile iron pool as compared to MCF-7 cells.	Iron	268-272	ferritin heavy chain 1	Homo sapiens	46-66
24880481-3	2014	While replacement therapy may be beneficial, dietary iron absorption is impaired in PAH patients by hepcidin, a key regulatory protein of iron homoeostasis.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	100-108
21150441-3	2011	New proteins (hepcidin, hemojuvelin, HFE, TFR2 and ferroportin), mutated in hereditary hemochromatosis, have been identified with a crucial role in iron regulation.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	14-22
25252070-1	2014	Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive disease characterized by congenital hypochromic microcytic anemia, low transferrin saturation, low serum iron, normal-high serum ferritin, and increased hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	230-238
21150441-3	2011	New proteins (hepcidin, hemojuvelin, HFE, TFR2 and ferroportin), mutated in hereditary hemochromatosis, have been identified with a crucial role in iron regulation.	Iron	148-152	hemojuvelin BMP co-receptor	Homo sapiens	24-35
21150441-3	2011	New proteins (hepcidin, hemojuvelin, HFE, TFR2 and ferroportin), mutated in hereditary hemochromatosis, have been identified with a crucial role in iron regulation.	Iron	148-152	transferrin receptor 2	Homo sapiens	42-46
21150441-5	2011	Novel genetic forms of iron-related microcytic anemia have been identified, due to defects of iron transport/utilization or to TMPRSS6 deficiency and hepcidin hyperproduction, as occurs in iron-refractory iron deficiency anemia (IRIDA).	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	150-158
21150441-6	2011	A role for hepcidin has been identified also in acquired conditions, as in iron-loading anemias and in anemia of chronic diseases and inflammation.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	11-19
21283681-1	2011	BACKGROUND/AIMS: Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	17-25
21283681-1	2011	BACKGROUND/AIMS: Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	37-41
25252070-1	2014	Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive disease characterized by congenital hypochromic microcytic anemia, low transferrin saturation, low serum iron, normal-high serum ferritin, and increased hepcidin.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	230-238
20940420-2	2011	In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6).	Iron	14-18	bone morphogenetic protein 6	Mus musculus	70-74
25252070-5	2014	This case suggests that serum hepcidin should be routinely measured for differential diagnosis when patients with IDA are unresponsive to oral iron or have unusual clinical features.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	30-38
20940420-4	2011	We showed that loss of Bmp6 decreased hepcidin levels; increased hepatic iron; and, importantly, corrected hematologic abnormalities in Tmprss6(-/-) mice.	Iron	73-77	bone morphogenetic protein 6	Mus musculus	23-27
24410448-1	2014	Direct recordings of electron currents mediated by cytochromes b561 (CYB561) are not available yet, despite the importance of these proteins in a variety of physiological functions, including neurotransmitter synthesis and dietary iron uptake.	Iron	231-235	cytochrome b561	Homo sapiens	69-75
20940420-5	2011	This finding suggests that elevated hepcidin levels in patients with familial iron-refractory, iron-deficiency anemia are the result of excess signaling through the Bmp6/Hjv pathway.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	36-44
20940420-5	2011	This finding suggests that elevated hepcidin levels in patients with familial iron-refractory, iron-deficiency anemia are the result of excess signaling through the Bmp6/Hjv pathway.	Iron	78-82	hemojuvelin BMP co-receptor	Homo sapiens	170-173
25076907-3	2014	Cytokines and the acute phase protein hepcidin affect iron homeostasis leading to the retention of the metal within macrophages and hypoferremia.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	38-46
21171611-12	2011	The induction of oxidative stress and inflammatory responses (evaluated by HO-1 mRNA expression and TNF-alpha mRNA and protein expression) revealed a reduction in inflammogenicity upon iron loading and a more inflammogenic potency of DQ12 ascribed to undissociated SiOH interacting via H-bonding with cell membrane components.	Iron	185-189	heme oxygenase 1	Homo sapiens	75-79
21110943-1	2011	Upon interaction with bovine heart cardiolipin (CL), horse heart cytochrome c (cytc) changes its tertiary structure disrupting the heme-Fe-Met80 distal bond, reduces drastically the midpoint potential out of the range required for its physiological role, binds CO and NO with high affinity, and displays peroxidase activity.	Iron	136-138	cytochrome c, somatic	Equus caballus	65-77
25011704-8	2014	MPTP exaggerated iron elevation in young CP KO mice but did not increase cell death when compared to WTs.	Iron	17-21	ceruloplasmin	Mus musculus	41-43
22254194-3	2011	Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate carbon monoxide, biliverdin, and iron.	Iron	101-105	heme oxygenase 1	Homo sapiens	0-16
22254194-3	2011	Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate carbon monoxide, biliverdin, and iron.	Iron	101-105	heme oxygenase 1	Homo sapiens	18-22
25011704-9	2014	CONCLUSIONS: We conclude that there may exist a proportion of substantia nigra neurons that depend on CP for protection against iron neurotoxicity and could be protected by iron-based therapeutics.	Iron	128-132	ceruloplasmin	Mus musculus	102-104
24917476-5	2014	On the basis of DFT computation and the experimental (and calculated) reduction potential (E1/2) of complexes 1, 3, and 5, the NO-coordinate ligand(s) of complexes 1 and 3 serves as the stronger electron-donating ligand, compared to thiolate, to reduce the effective nuclear charge (Zeff) of the iron center and prevent DNIC 1 from dimerization in an organic solvent (MeCN).	Iron	296-300	small nucleolar RNA, H/ACA box 73A	Homo sapiens	91-121
21654163-0	2011	Reproducibility of and correspondence among different hepcidin forms in blood and urine and their relationships to iron status in healthy, male Guatemalan volunteers observed over 9 weeks.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	54-62
21654163-8	2011	CONCLUSION: Hepcidin-25 shows correspondence across biological fluids, and the background "status" of hepcidin activation may be related to the host"s iron stores, whereas prohepcidin concentrations showed no promise in this regard.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	102-110
24644245-0	2014	A novel mutation in the SLC40A1 gene associated with reduced iron export in vitro.	Iron	61-65	solute carrier family 40 member 1	Homo sapiens	24-31
22123640-8	2011	Iron in the developing fetus is accumulated against a concentration gradient and, in the case of maternal iron deficiency, the placenta can protect the fetus significantly through the increased expression of placental transferrin receptor together with a rise in divalent metal transporter 1 (DMT1).	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	263-291
22123640-8	2011	Iron in the developing fetus is accumulated against a concentration gradient and, in the case of maternal iron deficiency, the placenta can protect the fetus significantly through the increased expression of placental transferrin receptor together with a rise in divalent metal transporter 1 (DMT1).	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	293-297
21325818-5	2011	Expression levels of iron transport proteins including DMT1, TfR, Fpn1 and Heph were assessed by Western blot technique.	Iron	21-25	hephaestin	Rattus norvegicus	75-79
24644245-3	2014	A molecular study of the genes involved in iron metabolism (HFE, HJV, HAMP, TFR2, SLC40A1) was undertaken.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	70-74
21517759-4	2011	The active IDO conformer exists only in the presence of reducing cofactors (such as cytochrome b(5)), requiring the single electron reduction of ferric-to-ferrous iron (Fe(3+) Fe(2+)), which facilitates binding of L-Trp and O(2) to the enzyme active site.	Iron	163-167	indoleamine 2,3-dioxygenase 1	Homo sapiens	11-14
24644245-7	2014	These findings and the iron overload phenotype of the patient suggest that the novel mutation c.386T&gt;C (p.L129P) in the SLC40A1 gene has incomplete penetrance and causes the classical form of ferroportin disease.	Iron	23-27	solute carrier family 40 member 1	Homo sapiens	123-130
24781977-1	2014	Myoglobin is a primary iron, and oxygen-binding protein of muscle tissues and levels can be an important diagnostic biomarker for acute myocardial infarction, myocardial necrosis, or other cardiac diseases.	Iron	23-27	myoglobin	Homo sapiens	0-9
20934533-0	2011	Cellular iron depletion weakens induction of heme oxygenase-1 by cadmium.	Iron	9-13	heme oxygenase 1	Homo sapiens	45-61
20934533-4	2011	This effect of cadmium was weaker in cells made iron-deficient with the iron chelator, desferrioxamine, which was associated with repression of heme oxygenase-1 protein and mRNA expression.	Iron	48-52	heme oxygenase 1	Homo sapiens	144-160
20934533-4	2011	This effect of cadmium was weaker in cells made iron-deficient with the iron chelator, desferrioxamine, which was associated with repression of heme oxygenase-1 protein and mRNA expression.	Iron	72-76	heme oxygenase 1	Homo sapiens	144-160
20934533-5	2011	The repression by desferrioxamine of cadmium-induced heme oxygenase-1 upregulation was reversed upon iron replenishment of the cells.	Iron	101-105	heme oxygenase 1	Homo sapiens	53-69
20934533-10	2011	It is concluded that adequate amounts of iron, which at the atomic level can serve as the pivotal element of heme in NADPH oxidase, must be present in cells to permit what appears to be thiol redox-sensitive, NADPH oxidase-dependent upregulation of heme oxygenase-1.	Iron	41-45	heme oxygenase 1	Homo sapiens	249-265
24768787-3	2014	Specifically, recent studies have demonstrated that in breast cancer cells, the expression/activity of several iron-related proteins, such as ferritin, hepcidin and ferroportin, is deregulated and that these alterations may have a prognostic impact in patients with breast cancer.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	152-160
21210258-2	2011	The coordination of iron acquisition and utilization is mediated by the interaction of the peptide hormone hepcidin and the iron exporter ferroportin.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	107-115
21210258-2	2011	The coordination of iron acquisition and utilization is mediated by the interaction of the peptide hormone hepcidin and the iron exporter ferroportin.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	107-115
21210258-4	2011	Hepcidin is a negative regulator of iron export.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
21210258-5	2011	Hepcidin binds to cell surface ferroportin inducing ferroportin degradation and decreasing cellular iron export.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-8
21210258-6	2011	Genetic disorders of iron overload of iron-linked anemia can be explained by changes in the level of hepcidin or ferroportin and of the ability of ferroportin to be internalized by hepcidin.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	101-109
24281368-6	2014	Fdx2 is the second component of the Fe-S cluster biogenesis machinery, the first being IscU that is associated with isolated mitochondrial myopathy.	Iron	36-40	ferredoxin 2	Homo sapiens	0-4
21183018-4	2011	Lactoferrin is an iron-binding protein that has been reported to inhibit several types of cancer.	Iron	18-22	lactotransferrin	Bos taurus	0-11
24500395-1	2014	UNLABELLED: Hepcidin is a regulator of iron balance that is increased in obesity.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	12-20
22118000-0	2011	Serum hepcidin in haemodialysis patients: associations with iron status and microinflammation.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	6-14
24500395-13	2014	Serum hepcidin could be a marker of iron metabolism status and NAFLD in these groups of patients.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	6-14
22118000-1	2011	Hepcidin plays a key role in iron homeostasis.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
24687636-17	2014	CONCLUSIONS: In PD patients without hospitalization, intercurrent disease(s) or IV iron therapy, young age, higher albumin or RRF and lower CIMT were associated with greater oscillations in response to ESA therapy.	Iron	83-87	CIMT	Homo sapiens	140-144
22118000-6	2011	In conclusion, serum hepcidin levels are associated  with iron status and microinflammation (defined as hsCRP &lt; 15 mg/l, without clinical manifestation of inflammation) in maintenance haemodialysis patients.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	21-29
24962818-3	2014	Hepcidin has been a key role in controlling iron transport in both humans and animals and in mediating anemia of inflammatory disease in humans.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
24777603-3	2014	Depletion of the mammalian siderophore by inhibiting expression of bdh2 results in abnormal accumulation of intracellular iron and mitochondrial iron deficiency in cultured mammalian cells, as well as in yeast cells and zebrafish embryos We disrupted murine bdh2 by homologous recombination to analyze the effect of bdh2 deletion on erythropoiesis and iron metabolism.	Iron	122-126	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	67-71
24777603-3	2014	Depletion of the mammalian siderophore by inhibiting expression of bdh2 results in abnormal accumulation of intracellular iron and mitochondrial iron deficiency in cultured mammalian cells, as well as in yeast cells and zebrafish embryos We disrupted murine bdh2 by homologous recombination to analyze the effect of bdh2 deletion on erythropoiesis and iron metabolism.	Iron	145-149	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	67-71
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	8-12	Tis11p	Saccharomyces cerevisiae S288C	44-48
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	8-12	Yap5p	Saccharomyces cerevisiae S288C	53-57
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	Tis11p	Saccharomyces cerevisiae S288C	44-48
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	Yap5p	Saccharomyces cerevisiae S288C	53-57
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	Tis11p	Saccharomyces cerevisiae S288C	44-48
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	Yap5p	Saccharomyces cerevisiae S288C	53-57
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	Tis11p	Saccharomyces cerevisiae S288C	44-48
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	Yap5p	Saccharomyces cerevisiae S288C	53-57
24927015-12	2014	The levels of iron in the serum of coinfected patients with a CD4+T-cell count &lt;500/microl were lower than those in patients with a CD4+T-cell count &gt;=500/microl, whereas serum hepcidin levels showed the opposite trend.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	183-191
24926268-1	2014	Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	58-66
24926268-1	2014	Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	58-66
24926268-1	2014	Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	58-66
24796871-0	2014	Csa2, a member of the Rbt5 protein family, is involved in the utilization of iron from human hemoglobin during Candida albicans hyphal growth.	Iron	77-81	IK cytokine	Homo sapiens	0-4
24796871-3	2014	Csa2 is involved in iron uptake from hemoglobin and heme proteins; however, its precise role is unclear.	Iron	20-24	IK cytokine	Homo sapiens	0-4
24796871-4	2014	Here, we provide quantitative evidence of the involvement of Csa2 in the utilization of iron from human hemoglobin during C. albicans hyphal growth.	Iron	88-92	IK cytokine	Homo sapiens	61-65
24796871-8	2014	Furthermore, hemoglobin binding was impaired in the csa2Delta/Delta mutant compared with the wt and csa2Delta/Delta::CSA2 strains, revealing that Csa2 is involved in the utilization of hemoglobin as an iron source by the hyphal form of C. albicans.	Iron	202-206	IK cytokine	Homo sapiens	146-150
24615902-3	2014	Unexpectedly, ceruloplasmin (Cp), a ferroxidase that converts toxic ferrous iron to its nontoxic ferric form and also promotes the efflux of iron from astrocytes in the CNS, was shown to be highly upregulated (13.2-fold increase) in EAE spinal cord.	Iron	76-80	ceruloplasmin	Mus musculus	14-27
24615902-3	2014	Unexpectedly, ceruloplasmin (Cp), a ferroxidase that converts toxic ferrous iron to its nontoxic ferric form and also promotes the efflux of iron from astrocytes in the CNS, was shown to be highly upregulated (13.2-fold increase) in EAE spinal cord.	Iron	141-145	ceruloplasmin	Mus musculus	14-27
24729039-0	2014	Effect of iron status in rats on the absorption of metal ions from plant ferritin.	Iron	10-14	ferritin-1, chloroplastic	Glycine max	73-81
24729039-8	2014	Additionally, we may also suspect based on the obtained results that absorption of ferritin-iron depends on iron status in the body.	Iron	92-96	ferritin-1, chloroplastic	Glycine max	83-91
24729039-8	2014	Additionally, we may also suspect based on the obtained results that absorption of ferritin-iron depends on iron status in the body.	Iron	108-112	ferritin-1, chloroplastic	Glycine max	83-91
24687133-1	2014	RATIONALE: Ceruloplasmin antioxidant function is mainly related to its ferroxidase I (FeOxI) activity, which influences iron-dependent oxidative and nitrosative radical species generation.	Iron	120-124	ceruloplasmin	Homo sapiens	11-24
24847269-4	2014	Two forms are linked to mutations in genes directly involved in iron metabolism: neuroferritinopathy, associated to mutations in the FTL gene and aceruloplasminemia, where the ceruloplasmin gene product is defective.	Iron	64-68	ceruloplasmin	Homo sapiens	147-160
24807559-0	2014	Expression of the iron hormone hepcidin distinguishes different types of anemia in African children.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	31-39
24807559-3	2014	The peptide hormone hepcidin governs iron absorption; hepcidin transcription is mediated by iron, inflammation, and erythropoietic signals.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	20-28
24807559-3	2014	The peptide hormone hepcidin governs iron absorption; hepcidin transcription is mediated by iron, inflammation, and erythropoietic signals.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	54-62
24807559-6	2014	A retrospective secondary analysis of published data from 25 Gambian children with either postmalarial or nonmalarial anemia demonstrated that hepcidin measurements identified individuals who incorporated &gt;20% oral iron into their erythrocytes.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	143-151
24231125-2	2014	In the last decade, the hepatic hormone hepcidin has been progressively recognized as the master regulator of circulating iron levels through the modulation of cellular iron fluxes in response to iron stores, as well as to erythroid and inflammatory stimuli.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	40-48
24231125-2	2014	In the last decade, the hepatic hormone hepcidin has been progressively recognized as the master regulator of circulating iron levels through the modulation of cellular iron fluxes in response to iron stores, as well as to erythroid and inflammatory stimuli.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	40-48
24231125-2	2014	In the last decade, the hepatic hormone hepcidin has been progressively recognized as the master regulator of circulating iron levels through the modulation of cellular iron fluxes in response to iron stores, as well as to erythroid and inflammatory stimuli.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	40-48
24231125-4	2014	This, in turn, reduces iron availability for erythropoiesis, suggesting anti-hepcidin strategies for improving anemia control.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	77-85
24598841-1	2014	Dysregulation of hepcidin, a key iron regulating hormone, is important in the pathogenesis of iron overload in patients with myelodysplatic syndrome (MDS).	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	17-25
24598841-1	2014	Dysregulation of hepcidin, a key iron regulating hormone, is important in the pathogenesis of iron overload in patients with myelodysplatic syndrome (MDS).	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	17-25
24666349-2	2014	Iron starvation does, however, result in expression of SbnG, recently identified as a novel citrate synthase that is encoded from within the iron-regulated SB biosynthetic locus, suggesting an important role for SbnG in staphyloferrin production.	Iron	0-4	AT695_RS09050	Staphylococcus aureus	92-108
24666349-2	2014	Iron starvation does, however, result in expression of SbnG, recently identified as a novel citrate synthase that is encoded from within the iron-regulated SB biosynthetic locus, suggesting an important role for SbnG in staphyloferrin production.	Iron	141-145	AT695_RS09050	Staphylococcus aureus	92-108
24795637-5	2014	In the last decade, the discovery of the iron regulatory hormone hepcidin has revolutionized our understanding of iron pathophysiology.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	65-73
24795637-5	2014	In the last decade, the discovery of the iron regulatory hormone hepcidin has revolutionized our understanding of iron pathophysiology.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	65-73
24764672-6	2014	Additionally, the ability of iron, pathogen-derived molecules and IL-6 to induce hepcidin expression in HT-29 cells was evaluated.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	81-89
24860503-3	2014	HO-1 releases Fe(2+) from heme, and the ferritin heavy chain (FHC) ferroxidase oxidizes Fe(2+) to catalytically inactive Fe(3+) inside ferritin.	Iron	88-90	ceruloplasmin	Mus musculus	67-78
23934922-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: We investigated the interplay of reactive oxygen species, antioxidants and iron oxidation state in regard to alpha-synuclein aggregation using confocal single particle fluorescence spectroscopy, Phenanthroline spectrometry and thiobarbituric acid reactive substances assay.	Iron	107-111	synuclein alpha	Homo sapiens	141-156
23934922-8	2011	CONCLUSIONS/SIGNIFICANCE: Our data thus indicate that oxidative stress affects alpha-synuclein aggregation via oxidation of iron to the ferric state.	Iron	124-128	synuclein alpha	Homo sapiens	79-94
24387766-0	2014	Black soyabean seed coat extract regulates iron metabolism by inhibiting the expression of hepcidin.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	91-99
20947636-2	2011	Here, we hypothesize that elevations in tissue iron can activate caspase-dependent signaling, which leads to increased cardiac apoptosis and fibrosis, and that these alterations can be attenuated by iron chelation.	Iron	47-51	caspase 9	Homo sapiens	65-72
24387766-1	2014	Hepcidin, a key regulator of Fe homeostasis, is an ideal drug target for treating patients with Fe disorders such as haemochromatosis, anaemia of chronic inflammation and Fe-deficiency anaemia.	Iron	29-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
20947636-2	2011	Here, we hypothesize that elevations in tissue iron can activate caspase-dependent signaling, which leads to increased cardiac apoptosis and fibrosis, and that these alterations can be attenuated by iron chelation.	Iron	199-203	caspase 9	Homo sapiens	65-72
20947636-6	2011	These results suggest that the activation of caspase-dependent signaling may play a role in the development of iron-induced cardiac apoptosis and fibrosis, and deferasirox, via a reduction in cardiac tissue iron levels, may be useful for decreasing the extent of iron-induced cardiac damage.	Iron	111-115	caspase 9	Homo sapiens	45-52
24387766-8	2014	In conclusion, these results indicate that black soyabean extract regulates Fe metabolism by inhibiting the expression of hepcidin.	Iron	76-78	hepcidin antimicrobial peptide	Homo sapiens	122-130
24584132-0	2014	A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters.	Iron	45-49	ATP binding cassette subfamily B member 7	Homo sapiens	84-89
21401293-9	2011	In conclusion, the present results indicate a direct effect of iron on 1) secretion of growth factor IGF-I but not steroid hormone progesterone, 2) expression of markers of proliferation (cyclin B1), or 3) apoptosis (caspase-3) of porcine ovarian granulosa cells.	Iron	63-67	cyclin B1	Homo sapiens	188-197
21401300-1	2011	Hepcidin, a recently discovered antimicrobial peptide synthesized in the liver, was identified to be the key mediator of iron metabolism and distribution.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	0-8
24589273-0	2014	Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	14-22
21949858-1	2011	Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficking.	Iron	86-90	ceruloplasmin	Mus musculus	0-13
21949858-8	2011	Chelator-mediated depletion of iron in cultured neural cells resulted in reduced BDNF expression by a posttranscriptional mechanism, suggesting a causal link between low brain iron levels and reduced BDNF expression.	Iron	31-35	brain derived neurotrophic factor	Mus musculus	81-85
21949858-8	2011	Chelator-mediated depletion of iron in cultured neural cells resulted in reduced BDNF expression by a posttranscriptional mechanism, suggesting a causal link between low brain iron levels and reduced BDNF expression.	Iron	31-35	brain derived neurotrophic factor	Mus musculus	200-204
21949858-8	2011	Chelator-mediated depletion of iron in cultured neural cells resulted in reduced BDNF expression by a posttranscriptional mechanism, suggesting a causal link between low brain iron levels and reduced BDNF expression.	Iron	176-180	brain derived neurotrophic factor	Mus musculus	81-85
21949858-8	2011	Chelator-mediated depletion of iron in cultured neural cells resulted in reduced BDNF expression by a posttranscriptional mechanism, suggesting a causal link between low brain iron levels and reduced BDNF expression.	Iron	176-180	brain derived neurotrophic factor	Mus musculus	200-204
21887333-2	2011	In this process, iron acts as a critical cofactor, with iron deficiency blunting EPO-responsiveness of erythroid progenitors.	Iron	17-21	erythropoietin	Mus musculus	81-84
24589273-1	2014	In this article, the authors discuss new approaches to treating iron overload diseases using hepcidin mimetics or by modulating endogenous hepcidin expression.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	93-101
21887333-12	2011	We propose a model in which aconitase functions as a licensing factor in ERK-dependent proliferation and differentiation, thereby providing a regulatory input for iron in EPO-dependent erythropoiesis.	Iron	163-167	erythropoietin	Mus musculus	171-174
24589273-1	2014	In this article, the authors discuss new approaches to treating iron overload diseases using hepcidin mimetics or by modulating endogenous hepcidin expression.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	139-147
24549117-9	2014	The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl.	Iron	19-23	H[+]-ATPase 7	Arabidopsis thaliana	64-68
20863724-7	2010	We found that in human liver, not only HAMP, but also SMAD7 and Id1 mRNA significantly correlate with the extent of hepatic iron burden.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	39-43
24688754-12	2014	An elevated hepcidin level may identify patients with IDA who will not respond to oral iron but will respond to FCM.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	12-20
20826723-4	2010	TfR2 is involved in iron metabolism by regulating hepcidin production in liver cells.	Iron	20-24	transferrin receptor 2	Homo sapiens	0-4
24667393-11	2014	An athlete"s iron stores may dictate the baseline hepcidin levels and the magnitude of post-exercise hepcidin response.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	50-58
20704546-1	2010	Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous iron.	Iron	79-91	heme oxygenase 1	Homo sapiens	0-16
20704546-1	2010	Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous iron.	Iron	79-91	heme oxygenase 1	Homo sapiens	18-22
20704548-3	2010	HO-1 catalyzes the degradation of free cellular heme to iron, carbon monoxide (CO) and biliverdin which is eventually converted to bilirubin by biliverdin reductase.	Iron	56-60	heme oxygenase 1	Homo sapiens	0-4
20704549-1	2010	Heme oxygenase-1 (HO-1), an enzyme degrading heme to carbon monoxide, free iron, and biliverdin, participates in the cell defence against oxidative stress and it has been speculated that it might be a new therapeutic target for neuroprotection.	Iron	75-79	heme oxygenase 1	Homo sapiens	0-16
20704549-1	2010	Heme oxygenase-1 (HO-1), an enzyme degrading heme to carbon monoxide, free iron, and biliverdin, participates in the cell defence against oxidative stress and it has been speculated that it might be a new therapeutic target for neuroprotection.	Iron	75-79	heme oxygenase 1	Homo sapiens	18-22
20704550-1	2010	Heme oxygenase-1 (HO-1) metabolizes heme to generate carbon monoxide (CO), biliverdin, and iron.	Iron	91-95	heme oxygenase 1	Homo sapiens	0-16
24667393-11	2014	An athlete"s iron stores may dictate the baseline hepcidin levels and the magnitude of post-exercise hepcidin response.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	101-109
24667393-12	2014	Low iron stores suppressed post-exercise hepcidin, seemingly overriding any inflammatory-driven increases.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	41-49
20888657-3	2010	Recently, hepcidin was identified as a regulator of iron metabolism.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	10-18
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Iron	199-203	hexosaminidase subunit alpha	Homo sapiens	4-8
20713458-1	2010	BACKGROUND: Hemojuvelin, a critical regulator of iron homeostasis, is involved in the regulation of hepcidin expression and iron homeostasis.	Iron	49-53	hemojuvelin BMP co-receptor	Homo sapiens	12-23
20713458-1	2010	BACKGROUND: Hemojuvelin, a critical regulator of iron homeostasis, is involved in the regulation of hepcidin expression and iron homeostasis.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	100-108
20713458-1	2010	BACKGROUND: Hemojuvelin, a critical regulator of iron homeostasis, is involved in the regulation of hepcidin expression and iron homeostasis.	Iron	124-128	hemojuvelin BMP co-receptor	Homo sapiens	12-23
25097830-12	2014	In conclusion, vitamin D regulates the hepcidin-ferroportin axis in macrophages which may facilitate iron egress.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	39-47
20713458-9	2010	Patients with iron-refractory iron-deficiency anemia with a mutation in the TMPRSS6 gene were found to have lower levels of circulating hemojuvelin than those in healthy patients.	Iron	14-18	hemojuvelin BMP co-receptor	Homo sapiens	136-147
24370385-0	2014	Monitoring of hepcidin levels in a patient with G80S-linked ferroportin disease undergoing iron depletion by phlebotomy.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	14-22
24568283-4	2014	Here, we report the identification and characterization of three oxygenases from the fumagillin biosynthetic pathway, including a multifunctional cytochrome P450 monooxygenase, a hydroxylating nonheme-iron-dependent dioxygenase, and an ABM family monooxygenase for oxidative cleavage of the polyketide moiety.	Iron	201-205	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	146-175
21383490-4	2010	HO-1 breaks down heme to yield CO, iron and biliverdin.	Iron	35-39	heme oxygenase 1	Homo sapiens	0-4
24604200-4	2014	An Fe(IV)-oxo intermediate abstracts the hydrogen (H ) from C5, and tyrosine 165, a residue not visualized in the published structures of CarC lacking bound substrate, donates H  to the opposite face of the resultant radical.	Iron	3-5	complement C5	Homo sapiens	60-80
20801540-2	2010	Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facilitates cellular iron export and iron binding to transferrin.	Iron	98-102	ceruloplasmin	Homo sapiens	0-13
20801540-2	2010	Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facilitates cellular iron export and iron binding to transferrin.	Iron	114-118	ceruloplasmin	Homo sapiens	0-13
20801540-7	2010	Aceruloplasminemia was associated with severe brain and liver iron overload, where hepatic mRNA expression of the iron hormone hepcidin was increased, corresponding to the degree of iron overload.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	127-135
20801540-7	2010	Aceruloplasminemia was associated with severe brain and liver iron overload, where hepatic mRNA expression of the iron hormone hepcidin was increased, corresponding to the degree of iron overload.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	127-135
20801540-11	2010	Iron accumulation in aceruloplasminemia is a result of defective cellular iron export, where hepcidin regulation is appropriate for the degree of iron overload.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	93-101
20801540-11	2010	Iron accumulation in aceruloplasminemia is a result of defective cellular iron export, where hepcidin regulation is appropriate for the degree of iron overload.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	93-101
24606893-3	2014	(2014) show that the mitochondrial Fe-S cochaperone protein HSC20 guides nascent Fe-S clusters based on a highly conserved motif, LYR, that exists in target proteins in different molecular contexts.	Iron	35-37	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	60-65
20980658-1	2010	Heme iron absorption during pregnancy and the role of hepcidin in regulating dietary heme iron absorption remains largely unexplored.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	54-62
20980658-9	2010	In the group as a whole, women with undetectable serum hepcidin had greater nonheme iron utilization compared with women with detectable serum hepcidin (P = 0.02; n = 29); however, there were no significant differences in heme iron utilization.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	55-63
24606893-3	2014	(2014) show that the mitochondrial Fe-S cochaperone protein HSC20 guides nascent Fe-S clusters based on a highly conserved motif, LYR, that exists in target proteins in different molecular contexts.	Iron	35-39	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	60-65
24606901-4	2014	In succinate dehydrogenase B, two LYR motifs engage the ISCU-HSC20-HSPA9 complex to aid incorporation of three Fe-S clusters within the final structure of complex II.	Iron	111-115	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	61-66
24414856-5	2014	The zebrafish model of iron overload described in this study demonstrated an apparent inhibition of bone formation, accompanied by decreased expression of osteoblast-specific genes (runx2a, runx2b, osteocalcin, osteopontin, ALP, and collagen type I).	Iron	23-27	RUNX family transcription factor 2b	Danio rerio	190-196
20730621-8	2010	The increased level of oxidative stress in AD brain is reflected by the increased brain content of iron (Fe) and copper (Cu) both capable of stimulating free radical formation (e.g. hydroxyl radicals via Fenton reaction), increased protein and DNA oxidation in the AD brain, enhanced lipid peroxidation, decreased level of cytochrome c oxidase and advanced glycation end products (AGEs), carbonyls, malondialdehyde (MDA), peroxynitrite, and heme oxygenase-1 (HO-1).	Iron	99-103	heme oxygenase 1	Homo sapiens	441-457
20730621-8	2010	The increased level of oxidative stress in AD brain is reflected by the increased brain content of iron (Fe) and copper (Cu) both capable of stimulating free radical formation (e.g. hydroxyl radicals via Fenton reaction), increased protein and DNA oxidation in the AD brain, enhanced lipid peroxidation, decreased level of cytochrome c oxidase and advanced glycation end products (AGEs), carbonyls, malondialdehyde (MDA), peroxynitrite, and heme oxygenase-1 (HO-1).	Iron	99-103	heme oxygenase 1	Homo sapiens	459-463
20730621-8	2010	The increased level of oxidative stress in AD brain is reflected by the increased brain content of iron (Fe) and copper (Cu) both capable of stimulating free radical formation (e.g. hydroxyl radicals via Fenton reaction), increased protein and DNA oxidation in the AD brain, enhanced lipid peroxidation, decreased level of cytochrome c oxidase and advanced glycation end products (AGEs), carbonyls, malondialdehyde (MDA), peroxynitrite, and heme oxygenase-1 (HO-1).	Iron	105-107	heme oxygenase 1	Homo sapiens	441-457
21135991-0	2010	Increased intracellular iron and mineralization of cultured hFOB 1.19 cells following hepcidin activation through ferroportin-1.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	86-94
21135991-0	2010	Increased intracellular iron and mineralization of cultured hFOB 1.19 cells following hepcidin activation through ferroportin-1.	Iron	24-28	solute carrier family 40 member 1	Homo sapiens	114-127
21135991-7	2010	On the basis of which, it was found that 25noml/L, 50noml/L, 100noml/L hepcidin could promote the fluorescence intensity related to intracellular iron concentration and mineralization in hFOB 1.19 in a dose-dependent manner (p&lt;0.05), but hepcidin had no effect on FOB 1.19 proliferation (p&gt;0.05).	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	71-79
24414856-5	2014	The zebrafish model of iron overload described in this study demonstrated an apparent inhibition of bone formation, accompanied by decreased expression of osteoblast-specific genes (runx2a, runx2b, osteocalcin, osteopontin, ALP, and collagen type I).	Iron	23-27	bone gamma-carboxyglutamate (gla) protein	Danio rerio	198-209
21135991-9	2010	It is also suggested that cross-talk between iron and calcium homeostasis may play a role in bone metabolism in responding to hepcidin activation.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	126-134
24441148-0	2014	Serum hepcidin following autologous hematopoietic cell transplantation: an illustration of the interplay of iron status, erythropoiesis and inflammation.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	6-14
20851044-0	2010	Spectrofluorometric study of iron removal from bovine lactoferrin by ethylenediamminetetraacetic acid.	Iron	29-33	lactotransferrin	Bos taurus	54-65
23775519-1	2014	UNLABELLED: Defects in human hemochromatosis protein (HFE) cause iron overload due to reduced hepatic hepcidin secretion.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	102-110
20851044-1	2010	The kinetics of iron removal from the two metal binding sites of the bovine lactoferrin by ethylenediaminetetraacetic acid (EDTA) was investigated at pH 7.5 and 33 C. Solutions were buffered at pH 7.5 by 0.15 M Tris-HCl.	Iron	16-20	lactotransferrin	Bos taurus	76-87
20851044-2	2010	Pseudo first-order rate constants as a function of ligand concentration were measured for iron removal from diferric lactoferrin and from N- and C-terminal monoferric lactoferrin.	Iron	90-94	lactotransferrin	Bos taurus	117-128
20851044-3	2010	Diferric lactoferrin showed simple saturation behavior while both the monoferric forms showed a two-term dependence of kobs on ligand concentration that signifies two pathways for iron removal under the conditions applied.	Iron	180-184	lactotransferrin	Bos taurus	9-20
24204002-0	2014	Suppression of iron-regulatory hepcidin by vitamin D.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	31-39
21028817-4	2010	Binding of CO to l-Trp-bound IDO causes a significant change in the electronic and RR spectra of the heme, indicating that the pi* orbitals of the carbon atom of CO interact with pi orbitals of Fe and the porphyrin.	Iron	194-196	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
20958043-5	2010	The concentration of LF-bound iron decreased from 174 mug L(-1) for the LF treated in 0.2 strength SMUF to 80 mug L(-1) for that treated in double-strength SMUF.	Iron	30-34	lactotransferrin	Bos taurus	21-23
24204002-1	2014	The antibacterial protein hepcidin regulates the absorption, tissue distribution, and extracellular concentration of iron by suppressing ferroportin-mediated export of cellular iron.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	26-34
20958043-5	2010	The concentration of LF-bound iron decreased from 174 mug L(-1) for the LF treated in 0.2 strength SMUF to 80 mug L(-1) for that treated in double-strength SMUF.	Iron	30-34	lactotransferrin	Bos taurus	72-74
20958043-6	2010	The results suggest that the PEF-induced iron depletion of LF does not appear to cause an appreciable conformational change in LF molecules.	Iron	41-45	lactotransferrin	Bos taurus	59-61
24204002-1	2014	The antibacterial protein hepcidin regulates the absorption, tissue distribution, and extracellular concentration of iron by suppressing ferroportin-mediated export of cellular iron.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	26-34
20958043-7	2010	PEF treatment could be developed as a novel physical way to produce iron-depleted LF, as an alternative to the existing chemical method.	Iron	68-72	lactotransferrin	Bos taurus	82-84
24204002-6	2014	Suppression of HAMP expression was associated with a concomitant increase in expression of the cellular target for hepcidin, ferroportin protein, and decreased expression of the intracellular iron marker ferritin.	Iron	192-196	hepcidin antimicrobial peptide	Homo sapiens	15-19
24804175-3	2014	The inherited predisposition to excessive absorption of dietary iron in HH is almost always the result of homozygosity of the C282Y mutation of the HFE gene, which causes inappropriately low secretion of hepcidin.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	204-212
20819077-0	2010	Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron.	Iron	14-18	solute carrier family 11 member 2	Homo sapiens	123-127
24586229-9	2014	Compared with normal iron profiles, hepcidin was severely depressed in absolute ID but higher in hypotransferrinaemia.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	36-44
20819077-0	2010	Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron.	Iron	67-79	solute carrier family 11 member 2	Homo sapiens	123-127
20819077-6	2010	The acquisition of this additional iron depends on effluxed ascorbate and can be blocked by the DMT1 inhibitor ferristatin/NSC306711.	Iron	35-39	solute carrier family 11 member 2	Homo sapiens	96-100
20980392-5	2010	ATF1 is a transcriptional repressor of ferritin H, the major intracellular iron storage gene, through an ARE (antioxidant-responsive element).	Iron	75-79	activating transcription factor 1	Homo sapiens	0-4
24596553-4	2014	In contrast the existing PBNRR in ITK relies on homogeneous static FE model designed for brain shift only (i.e., it is not designed to handle brain tumor resection).	Iron	67-69	IL2 inducible T cell kinase	Homo sapiens	34-37
20620132-1	2010	Hepcidin is a liver-synthesized hormone that inhibits the cellular efflux of iron by binding to ferroportin and its subsequent degradation.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
24596558-8	2014	It is also found that, by maintaining mitochondrial iron homeostasis, FtMt could prevent 6-hydroxydopamine induced dopaminergic cell damage in Parkinson"s disease.	Iron	52-56	ferritin mitochondrial	Homo sapiens	70-74
20620132-3	2010	Recent studies implicate hepcidin in a variety of iron disorders in addition to its primary role in the regulation of systemic iron homeostasis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	25-33
20620132-4	2010	Hepcidin excess has a key pathologic role in anemia of inflammation, chronic kidney disease, and iron-refractory iron deficiency anemia, while hepcidin deficiency is responsible for most cases of familial hemochromatosis and iron-loading anemia.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
24596558-9	2014	These recent findings on FtMt regarding its functions in regulation of brain iron homeostasis and its protective role in pathogenesis of neurodegenerative diseases are summarized and reviewed.	Iron	77-81	ferritin mitochondrial	Homo sapiens	25-29
20620132-5	2010	The most important advances on the role of hepcidin in normal and abnormal iron metabolism and the main clinical and diagnostic implications are summarized in this review.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	43-51
20639400-3	2010	The pathogenic FANCJ-A349P amino acid substitution resides immediately adjacent to a highly conserved cysteine of the iron-sulfur domain.	Iron	118-122	BRCA1 interacting helicase 1	Homo sapiens	15-20
20639400-5	2010	Purified recombinant FANCJ-A349P protein had reduced iron and was defective in coupling adenosine triphosphate (ATP) hydrolysis and translocase activity to unwinding forked duplex or G-quadruplex DNA substrates or disrupting protein-DNA complexes.	Iron	53-57	BRCA1 interacting helicase 1	Homo sapiens	21-26
24520384-2	2014	Hepcidin, the major hormone controlling the availability of iron, is raised during acute and asymptomatic parasitemia.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
20932062-0	2010	Binding of reduced nicotinamide adenine dinucleotide phosphate destabilizes the iron-sulfur clusters of human mitoNEET.	Iron	80-84	CDGSH iron sulfur domain 1	Homo sapiens	110-118
27335844-7	2014	Iron reduction therapy significantly reduced the median level of serum AFP from 13 to 7 ng/mL, ALT from 96 to 50 IU/L, gamma-glutamyl transpeptidase (GGT) from 55 to 28 IU/L, and ferritin from 191 to 10 ng/mL (P &lt; 0.001 for each).	Iron	0-4	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	150-153
21073997-1	2010	Hepcidin, a 25-amino-acid peptide secreted by the liver, distributed in the plasma and excreted in urine, is a key central regulator of body iron homeostasis.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	0-8
21073997-4	2010	We noticed in the sequence of hepcidin a Cys*-X-Cys* motif which can act as a metal binding site able to trap iron and/or copper.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	30-38
27335844-13	2014	Iron reduction by therapeutic phlebotomy can reduce serum AFP and GGT levels in chronic hepatitis C patients.	Iron	0-4	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	66-69
24334869-1	2014	OBJECTIVE: Iron and the iron regulatory hormone hepcidin, major determinant of body iron distribution, are hypothesized to play a role in cardiovascular disease.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	48-56
20847326-1	2010	BACKGROUND: Hepcidin, a key regulator of iron metabolism, binds to the iron transporter ferroportin to cause its degradation.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	12-20
20847326-10	2010	This ELISA should help to improve our understanding of the role of hepcidin in regulating iron metabolism.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	67-75
24327293-1	2014	Divalent Metal Transporter 1 (DMT1) is an apical Fe transporter in the duodenum and is involved in endosomal Fe export.	Iron	49-51	solute carrier family 11 member 2	Homo sapiens	0-28
24327293-1	2014	Divalent Metal Transporter 1 (DMT1) is an apical Fe transporter in the duodenum and is involved in endosomal Fe export.	Iron	49-51	solute carrier family 11 member 2	Homo sapiens	30-34
20739079-9	2010	CONCLUSIONS: In patients with NAFLD, predominant hepatocellular iron deposition is often related to genetic factors, among which beta-globin mutations play a major role, predisposing to parenchymal iron accumulation and to progressive liver fibrosis.	Iron	64-68	hemoglobin subunit beta	Homo sapiens	129-140
20739079-9	2010	CONCLUSIONS: In patients with NAFLD, predominant hepatocellular iron deposition is often related to genetic factors, among which beta-globin mutations play a major role, predisposing to parenchymal iron accumulation and to progressive liver fibrosis.	Iron	198-202	hemoglobin subunit beta	Homo sapiens	129-140
24236640-7	2014	ATOH8 is therefore a novel transcriptional regulator of HAMP, which is responsive to changes in plasma iron and erythroid activity and could explain how changes in erythroid activity lead to regulation of HAMP.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	56-60
20819190-1	2010	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme catabolism that converts heme to Fe++, carbon monoxide and biliverdin.	Iron	93-97	heme oxygenase 1	Homo sapiens	0-16
20819190-1	2010	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme catabolism that converts heme to Fe++, carbon monoxide and biliverdin.	Iron	93-97	heme oxygenase 1	Homo sapiens	18-22
24236640-7	2014	ATOH8 is therefore a novel transcriptional regulator of HAMP, which is responsive to changes in plasma iron and erythroid activity and could explain how changes in erythroid activity lead to regulation of HAMP.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	205-209
24359498-0	2014	The novel multi-target iron chelator, M30 modulates HIF-1alpha-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer"s disease mice.	Iron	23-27	hypoxia inducible factor 1, alpha subunit	Mus musculus	52-62
20709802-0	2010	Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARalpha dependent mechanism.	Iron	65-69	heme oxygenase 1	Homo sapiens	21-37
20709802-0	2010	Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARalpha dependent mechanism.	Iron	65-69	peroxisome proliferator activated receptor alpha	Homo sapiens	97-106
20709802-2	2010	Herein, we show that the deleterious effects of iron dextran on liver function and iron deposition were significantly reversed by adiponectin gene therapy, which was accompanied by AMP-activated protein kinase (AMPK) phosphorylation and heme oxygenase (HO)-1 induction.	Iron	48-52	heme oxygenase 1	Homo sapiens	237-258
24359498-0	2014	The novel multi-target iron chelator, M30 modulates HIF-1alpha-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer"s disease mice.	Iron	23-27	presenilin 1	Mus musculus	147-150
24184387-8	2014	The present results suggest that HIF-1alpha may mediate iron accumulation in hypoxic microglia and KC7F2, similar to deferoxamine, might provide limited protection against iron induced PWMD.	Iron	56-60	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
20406137-9	2010	Thus, the current studies suggest that cytosolic ferritin degradation precedes the release of iron in MtFt-expressing cells; that MtFt-induced cytosolic ferritin decrease is partially preventable by lysosomal protease inhibitors; and that both lysosomal and proteasomal pathways may be involved in cytosolic ferritin degradation.	Iron	94-98	ferritin mitochondrial	Homo sapiens	102-106
20406137-9	2010	Thus, the current studies suggest that cytosolic ferritin degradation precedes the release of iron in MtFt-expressing cells; that MtFt-induced cytosolic ferritin decrease is partially preventable by lysosomal protease inhibitors; and that both lysosomal and proteasomal pathways may be involved in cytosolic ferritin degradation.	Iron	94-98	ferritin mitochondrial	Homo sapiens	130-134
24347170-11	2014	Finally, in embryos of the ascorbate-deficient mutants vtc2-4, vtc5-1, and vtc5-2, the reducing activity and the iron concentration were reduced significantly.	Iron	113-117	GDP-L-galactose phosphorylase 1	Arabidopsis thaliana	55-61
20626300-3	2010	The link between iron homeostasis and inflammation is hepcidin.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	54-62
20626300-4	2010	Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	25-33
20804135-0	2010	Effect of bare and coated nanoscale zerovalent iron on tceA and vcrA gene expression in Dehalococcoides spp.	Iron	47-51	transcription elongation factor A1	Homo sapiens	55-59
20511664-0	2010	Severe iron deficiency blunts the response of the iron regulatory gene Hamp and pro-inflammatory cytokines to lipopolysaccharide.	Iron	7-11	hepcidin antimicrobial peptide	Homo sapiens	71-75
24475238-0	2014	Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.	Iron	92-96	Nedd4 family interacting protein 1	Homo sapiens	10-16
20511664-1	2010	BACKGROUND: Expression of the key iron regulatory hormone hepcidin is increased by some stimuli (iron loading, inflammation) but decreased by others (increased erythropoiesis, iron deficiency).	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	58-66
20511664-1	2010	BACKGROUND: Expression of the key iron regulatory hormone hepcidin is increased by some stimuli (iron loading, inflammation) but decreased by others (increased erythropoiesis, iron deficiency).	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	58-66
20511664-7	2010	Lipopolysaccharide-treated iron-deficient animals also showed lower liver alpha2m mRNA and reduced serum interleukin-6 and tumor necrosis factor-alpha, suggesting a more generalized effect of iron deficiency.	Iron	27-31	alpha-2-macroglobulin	Homo sapiens	74-81
20511664-9	2010	Huh7 cells treated with an iron chelator showed a blunted hepcidin response to interleukin-6, suggesting that the response of hepatic parenchymal cells to inflammatory cytokines may also be iron-dependent.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	58-66
20511664-9	2010	Huh7 cells treated with an iron chelator showed a blunted hepcidin response to interleukin-6, suggesting that the response of hepatic parenchymal cells to inflammatory cytokines may also be iron-dependent.	Iron	190-194	hepcidin antimicrobial peptide	Homo sapiens	58-66
20511664-11	2010	The ability of severe iron deficiency to blunt the response to lipopolysaccharide of both hepcidin and other markers of inflammation suggests that adequate iron levels are necessary for a full acute phase response.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	90-98
24475238-2	2014	The iron transport protein DMT1 is known to be increased in Parkinson"s brains linking functional transport mechanisms with iron accumulation.	Iron	4-8	doublesex and mab-3 related transcription factor 1	Homo sapiens	27-31
24475238-2	2014	The iron transport protein DMT1 is known to be increased in Parkinson"s brains linking functional transport mechanisms with iron accumulation.	Iron	124-128	doublesex and mab-3 related transcription factor 1	Homo sapiens	27-31
24475238-3	2014	The regulation of DMT1 is therefore critical to the management of iron uptake in the disease setting.	Iron	66-70	doublesex and mab-3 related transcription factor 1	Homo sapiens	18-22
24475238-6	2014	We report that in human Parkinson"s brains increased iron concentrations in the substantia nigra are associated with upregulated levels of Ndfip1 in dopaminergic neurons containing alpha-synuclein deposits.	Iron	53-57	Nedd4 family interacting protein 1	Homo sapiens	139-145
19968722-2	2010	The pathophysiology behind this process may involve hepcidin, a recently discovered peptide that acts by inhibiting iron absorption and promoting iron retention in reticuloendothelial macrophages.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	52-60
19968722-2	2010	The pathophysiology behind this process may involve hepcidin, a recently discovered peptide that acts by inhibiting iron absorption and promoting iron retention in reticuloendothelial macrophages.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	52-60
24475238-6	2014	We report that in human Parkinson"s brains increased iron concentrations in the substantia nigra are associated with upregulated levels of Ndfip1 in dopaminergic neurons containing alpha-synuclein deposits.	Iron	53-57	synuclein alpha	Homo sapiens	181-196
24475238-8	2014	We suggest that in Parkinson"s disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.	Iron	50-54	Nedd4 family interacting protein 1	Homo sapiens	92-98
24475238-8	2014	We suggest that in Parkinson"s disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.	Iron	50-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	132-136
24475238-8	2014	We suggest that in Parkinson"s disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.	Iron	50-54	Nedd4 family interacting protein 1	Homo sapiens	157-163
24384540-2	2014	They are often related to the dis-regulation of iron metabolism regulated by hepcidin, but the regulatory pathway of hepcidin in CRA is poorly understood.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	77-85
20660052-2	2010	OBJECTIVE: The aim was to test the hypothesis that testosterone-induced increase in hematocrit is associated with suppression of the iron regulatory peptide hepcidin.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	157-165
24384540-10	2014	CONCLUSIONS: Our findings suggest that tumor progression results in increased GDF-15 secretion, which may down-regulate hepcidin expression, resulting in iron overload in cancer patients; this phenomenon has also been found in some patients with sideropenic anemia due to chronic blood loss.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	120-128
24409331-2	2014	Functional inactivation of Hjv leads to severe iron overload in humans and mice due to marked suppression of the iron-regulatory hormone hepcidin.	Iron	47-51	hemojuvelin BMP co-receptor	Homo sapiens	27-30
20854981-1	2010	The aim of this work was to study the effect of milk supplementation with lactoferrin of different iron saturation on the manufacturing and characteristics of yogurt.	Iron	99-103	lactotransferrin	Bos taurus	74-85
24259288-0	2014	A novel germline PIGA mutation in Ferro-Cerebro-Cutaneous syndrome: a neurodegenerative X-linked epileptic encephalopathy with systemic iron-overload.	Iron	136-140	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	17-21
20938270-2	2010	Hepcidin is a liver-derived peptide that is a negative regulator of iron stores.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
20938270-3	2010	Hepcidin synthesis is suppressed by erythropoiesis and iron deficiency and upregulated by iron overload and inflammation.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
24259288-10	2014	In conclusion, the PIGA mutation in this family likely causes a reduction in GPI anchor protein cell surface expression in various cell types, resulting in the observed pleiotropic phenotype involving central nervous system, skin, and iron metabolism.	Iron	235-239	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	19-23
24959785-3	2014	The study describes the potential role of hepcidin and hemojuvelin in the pathogenesis of disorders of iron metabolism during malnutrition.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	42-50
20631677-6	2010	In Caco-2 cells, the addition of erythropoietin significantly increased the expression of apical divalent metal transporter 1 (DMT1) and basolateral ferroportin and, consequently, iron transport across the monolayer.	Iron	180-184	solute carrier family 11 member 2	Homo sapiens	127-131
20631677-7	2010	Taken together, our results show that erythropoietin not only exerts a powerful inhibitory action on the expression of hepcidin, thus permitting the release of iron from reticuloendothelial macrophages and intestinal enterocytes, but also acts directly on enterocytes to increase iron absorption.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	119-127
20631677-7	2010	Taken together, our results show that erythropoietin not only exerts a powerful inhibitory action on the expression of hepcidin, thus permitting the release of iron from reticuloendothelial macrophages and intestinal enterocytes, but also acts directly on enterocytes to increase iron absorption.	Iron	280-284	hepcidin antimicrobial peptide	Homo sapiens	119-127
24959785-3	2014	The study describes the potential role of hepcidin and hemojuvelin in the pathogenesis of disorders of iron metabolism during malnutrition.	Iron	103-107	hemojuvelin BMP co-receptor	Homo sapiens	55-66
20668427-3	2010	As hepcidin is a direct regulator of iron status, its measurement might be useful for monitoring patients with iron dysregulation.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	3-11
20668427-3	2010	As hepcidin is a direct regulator of iron status, its measurement might be useful for monitoring patients with iron dysregulation.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	3-11
24959785-4	2014	STATE OF KNOWLEDGE: The participation of hepcidin in regulating iron homeostasis encompasses inhibiting the absorption of food iron from enterocytes and inhibiting the release of stored iron from the reticuloendothelial system cells.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	41-49
24959785-4	2014	STATE OF KNOWLEDGE: The participation of hepcidin in regulating iron homeostasis encompasses inhibiting the absorption of food iron from enterocytes and inhibiting the release of stored iron from the reticuloendothelial system cells.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	41-49
24959785-4	2014	STATE OF KNOWLEDGE: The participation of hepcidin in regulating iron homeostasis encompasses inhibiting the absorption of food iron from enterocytes and inhibiting the release of stored iron from the reticuloendothelial system cells.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	41-49
24959785-7	2014	The involvement of haemojuvelin in the overall iron homeostasis is related with the regulation of expression of the hepcidin coding gene on the transcription level.	Iron	47-51	hemojuvelin BMP co-receptor	Homo sapiens	19-31
20075851-2	2010	Iron depletion in obesity is thought to be mediated by an inflammation-induced increase in the body"s main regulator of iron homeostasis, hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	138-146
20075851-2	2010	Iron depletion in obesity is thought to be mediated by an inflammation-induced increase in the body"s main regulator of iron homeostasis, hepcidin.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	138-146
24959785-7	2014	The involvement of haemojuvelin in the overall iron homeostasis is related with the regulation of expression of the hepcidin coding gene on the transcription level.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	116-124
20075851-3	2010	Elevated hepcidin can result in iron depletion as it prevents the release of dietary iron absorbed into the enterocytes, limiting replenishment of body iron losses.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	9-17
20075851-3	2010	Elevated hepcidin can result in iron depletion as it prevents the release of dietary iron absorbed into the enterocytes, limiting replenishment of body iron losses.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	9-17
24959785-9	2014	Observations and analyses conducted in vivo allowed the conclusion that soluble HJV and cell-related haemojuvelin regulate hepcidin expression in response to changes in iron concentration.	Iron	169-173	hemojuvelin BMP co-receptor	Homo sapiens	80-83
20075851-3	2010	Elevated hepcidin can result in iron depletion as it prevents the release of dietary iron absorbed into the enterocytes, limiting replenishment of body iron losses.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	9-17
24959785-9	2014	Observations and analyses conducted in vivo allowed the conclusion that soluble HJV and cell-related haemojuvelin regulate hepcidin expression in response to changes in iron concentration.	Iron	169-173	hemojuvelin BMP co-receptor	Homo sapiens	101-113
20075851-13	2010	Reduction in inflammation and hepcidin likely allow for enhanced dietary iron absorption resulting in an improved functional iron profile.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	30-38
20075851-13	2010	Reduction in inflammation and hepcidin likely allow for enhanced dietary iron absorption resulting in an improved functional iron profile.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	30-38
24959785-9	2014	Observations and analyses conducted in vivo allowed the conclusion that soluble HJV and cell-related haemojuvelin regulate hepcidin expression in response to changes in iron concentration.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	123-131
23981688-9	2014	Moreover, Hif-2alpha knockdown in HuTu cells led to a reduction in reductase activity and iron uptake.	Iron	90-94	endothelial PAS domain protein 1	Homo sapiens	10-20
20817278-3	2010	Like ceruloplasmin, APP catalytically oxidizes Fe(2+), loads Fe(3+) into transferrin, and has a major interaction with ferroportin in HEK293T cells (that lack ceruloplasmin) and in human cortical tissue.	Iron	47-49	ceruloplasmin	Homo sapiens	5-18
24648608-3	2014	Transferrin receptor 2 plays a critical role in iron homeostasis and variability in its gene may influence oxidative stress and AMD occurrence.	Iron	48-52	transferrin receptor 2	Homo sapiens	0-22
20599473-1	2010	We and others have previously reported that lactoferrin (LF), which acts as both an iron-binding protein and an inflammatory modulator, is strongly up-regulated in the brains of patients with Alzheimer"s disease (AD).	Iron	84-88	lactotransferrin	Mus musculus	44-55
20618092-7	2010	Hepcidin controls cellular iron efflux by binding to the iron export protein ferroportin, causing ferroportin to be phosphorylated and degraded in lysosomes.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
20618092-7	2010	Hepcidin controls cellular iron efflux by binding to the iron export protein ferroportin, causing ferroportin to be phosphorylated and degraded in lysosomes.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
25518452-12	2014	Thus, the iron metabolism disorders in celiac disease is a result of immunopathological process which results in a reduction in iron absorption in the gut due to the intestinal mucosa villous atrophy and to improve the hepcidin production by liver cells and iron depot blocking with the CDA development in 20% of children.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	219-227
20618092-8	2010	Finally, hepcidin inhibits iron release from the reticulo-endothelial system.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	9-17
20618092-9	2010	Increased expression of hepcidin leads to decreased iron absorption and iron deficient anemia.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	24-32
20618092-10	2010	Hepcidin, therefore, is a negative regulator of iron transport in plasma.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-8
20601671-9	2010	CONCLUSION: In this group of patients with combined heart and renal failure and anaemia, increased hepcidin levels were associated with markers of iron load and not with markers of inflammation.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	99-107
20601671-11	2010	In our group hepcidin seems to reflect iron load and response to EPO rather than inflammation and EPO resistance.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	13-21
20470893-1	2010	Hepcidin is an antimicrobial peptide (AMP) secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	0-8
20580464-3	2010	A different iron metabolism gene signature was detected in both macrophage types, with the heme regulatory molecules CD163 and Heme Oxygenase-1 (HO-1) being preferentially expressed by M2 (M-CSF) macrophages.	Iron	12-16	heme oxygenase 1	Homo sapiens	145-149
20580464-3	2010	A different iron metabolism gene signature was detected in both macrophage types, with the heme regulatory molecules CD163 and Heme Oxygenase-1 (HO-1) being preferentially expressed by M2 (M-CSF) macrophages.	Iron	12-16	colony stimulating factor 1	Homo sapiens	189-194
20607553-10	2010	Hepcidin, a peptide synthesized primarily by the liver, has been identified as the central regulator in iron homeostasis.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	0-8
20572014-8	2010	The structure is consistent with the fact that introduction of two mutations in the N-lobe of murine ICA (mICA) (W124R and S188Y) allowed it to bind iron with high affinity.	Iron	149-153	lactotransferrin	Mus musculus	84-90
20572014-11	2010	Additionally, a comparison of selection pressure (dN/dS) on functional residues reveals some interesting insights into the evolution of the TF family including that the N-lobe of lactoferrin may be in the process of eliminating its iron binding function.	Iron	232-236	lactotransferrin	Mus musculus	169-175
20572014-11	2010	Additionally, a comparison of selection pressure (dN/dS) on functional residues reveals some interesting insights into the evolution of the TF family including that the N-lobe of lactoferrin may be in the process of eliminating its iron binding function.	Iron	232-236	lactotransferrin	Mus musculus	179-190
20689484-1	2010	OBJECTIVES: Heme oxygenase 1 (HO-1) is rapidly induced by stress, degrading pro-oxidant heme into carbon monoxide, bilirubin, and free iron (Fe).	Iron	135-139	heme oxygenase 1	Homo sapiens	12-28
20689484-1	2010	OBJECTIVES: Heme oxygenase 1 (HO-1) is rapidly induced by stress, degrading pro-oxidant heme into carbon monoxide, bilirubin, and free iron (Fe).	Iron	135-139	heme oxygenase 1	Homo sapiens	30-34
20689484-1	2010	OBJECTIVES: Heme oxygenase 1 (HO-1) is rapidly induced by stress, degrading pro-oxidant heme into carbon monoxide, bilirubin, and free iron (Fe).	Iron	141-143	heme oxygenase 1	Homo sapiens	12-28
20689484-1	2010	OBJECTIVES: Heme oxygenase 1 (HO-1) is rapidly induced by stress, degrading pro-oxidant heme into carbon monoxide, bilirubin, and free iron (Fe).	Iron	141-143	heme oxygenase 1	Homo sapiens	30-34
20504881-0	2010	Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury.	Iron	11-15	C-C motif chemokine ligand 2	Homo sapiens	51-56
20504881-0	2010	Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury.	Iron	11-15	heme oxygenase 1	Homo sapiens	58-62
20504881-12	2010	We conclude that 1) parenteral iron formulations that stimulate redox signaling can evoke cyto/nephrotoxicity; 2) secondary adaptive responses to this injury (e.g., HO-1/NGAL induction) can initiate a renal tubular cytoresistant state; this suggests a potential new clinical application for intravenous Fe therapy; and 3) FMX is bioneutral regarding these responses.	Iron	31-35	heme oxygenase 1	Homo sapiens	165-169
20712769-2	2010	Iron homeostasis is regulated by the hepatic peptide hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	61-69
20712769-3	2010	Hepcidin controls dietary iron absorption, plasma iron concentrations, and tissue iron distribution.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	0-8
20712769-3	2010	Hepcidin controls dietary iron absorption, plasma iron concentrations, and tissue iron distribution.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
20712769-3	2010	Hepcidin controls dietary iron absorption, plasma iron concentrations, and tissue iron distribution.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
20518024-1	2010	Mutations in BCS1L, an assembly factor that facilitates the insertion of the catalytic Rieske Iron-Sulfur subunit into respiratory chain complex III, result in a wide variety of clinical phenotypes that range from the relatively mild Bjornstad syndrome to the severe GRACILE syndrome.	Iron	94-98	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	13-18
20580947-1	2010	A homozygous mutation in the complex III chaperone BCS1L causes GRACILE syndrome (intrauterine growth restriction, aminoaciduria, cholestasis, hepatic iron overload, lactacidosis).	Iron	151-155	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	51-56
20401692-12	2010	Fortification of CS with probiotics and EFE together had more impact on FE and ADG in buffalo calves.	Iron	41-43	ADG	Bos taurus	79-82
20597505-0	2010	Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes.	Iron	41-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	92-97
20597505-5	2010	Calcium and iron treatments decreased DMT-1 protein in Caco-2 cell membranes, although total DMT-1 in whole cell lysates was unchanged by either iron or calcium.	Iron	12-16	doublesex and mab-3 related transcription factor 1	Homo sapiens	38-43
20597505-7	2010	Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell.	Iron	38-42	doublesex and mab-3 related transcription factor 1	Homo sapiens	73-78
20597505-7	2010	Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell.	Iron	142-146	doublesex and mab-3 related transcription factor 1	Homo sapiens	73-78
20653062-0	2010	Hepcidin levels in hereditary hyperferritinemia: Insights into the iron-sensing mechanism in hepatocytes.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
20676377-2	2010	However, HO-1 protein levels are increased in dopaminergic neurons of Parkinson"s disease (PD) patients, suggesting its participation in free-iron deposition, oxidative stress and neurotoxicity.	Iron	142-146	heme oxygenase 1	Homo sapiens	9-13
20603012-2	2010	Iron metabolism is balanced by two regulatory systems, one that functions systemically and relies on the hormone hepcidin and the iron exporter ferroportin, and another that predominantly controls cellular iron metabolism through iron-regulatory proteins that bind iron-responsive elements in regulated messenger RNAs.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	113-121
20430895-1	2010	Ceruloplasmin is a multicopper oxidase required for correct iron homeostasis.Previously, we have identified a ceruloplasmin mutant associated with the iron overload disease aceruloplasminemia, which was unable to acquire copper from the mammalian pump ATP7B but could be produced in an enzymatically active form in yeast.	Iron	60-64	ceruloplasmin	Homo sapiens	0-13
20430895-1	2010	Ceruloplasmin is a multicopper oxidase required for correct iron homeostasis.Previously, we have identified a ceruloplasmin mutant associated with the iron overload disease aceruloplasminemia, which was unable to acquire copper from the mammalian pump ATP7B but could be produced in an enzymatically active form in yeast.	Iron	60-64	ceruloplasmin	Homo sapiens	110-123
20806393-5	2010	In contrast, the docked genistein conformation showed two different binding modes, and the A ring of genistein was oriented to the heme iron of CYP1A2.	Iron	136-140	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	144-150
20516639-0	2010	HIV-1 Rev-binding protein accelerates  cellular uptake of iron to drive  Notch-induced T cell leukemogenesis in mice.	Iron	58-62	ArfGAP with FG repeats 1	Mus musculus	0-25
20516639-6	2010	Indeed, iron-deficient mice developed Notch1-induced T-ALL substantially more slowly than control mice, further supporting a critical role for iron uptake during leukemogenesis.	Iron	8-12	notch 1	Mus musculus	38-44
20471131-6	2010	This Clinical Practice Guideline will therefore, focus on HFE-HC, while rarer forms of genetic iron overload recently attributed to pathogenic mutations of transferrin receptor 2, (TFR2), hepcidin (HAMP), hemojuvelin (HJV), or to a sub-type of ferroportin (FPN) mutations, on which limited and sparse clinical and epidemiologic data are available, will not be discussed.	Iron	95-99	transferrin receptor 2	Homo sapiens	156-178
20471131-6	2010	This Clinical Practice Guideline will therefore, focus on HFE-HC, while rarer forms of genetic iron overload recently attributed to pathogenic mutations of transferrin receptor 2, (TFR2), hepcidin (HAMP), hemojuvelin (HJV), or to a sub-type of ferroportin (FPN) mutations, on which limited and sparse clinical and epidemiologic data are available, will not be discussed.	Iron	95-99	transferrin receptor 2	Homo sapiens	181-185
20471131-6	2010	This Clinical Practice Guideline will therefore, focus on HFE-HC, while rarer forms of genetic iron overload recently attributed to pathogenic mutations of transferrin receptor 2, (TFR2), hepcidin (HAMP), hemojuvelin (HJV), or to a sub-type of ferroportin (FPN) mutations, on which limited and sparse clinical and epidemiologic data are available, will not be discussed.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	198-202
19816411-1	2010	Hepcidin, the body"s main regulator of systemic iron homeostasis, is upregulated in response to inflammation and is thought to play a role in the manifestation of iron deficiency (ID) observed in obese populations.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-8
19816411-2	2010	We determined systemic hepcidin levels and its association with body mass, inflammation, erythropoiesis, and iron status in premenopausal obese and nonobese women (n = 20/group) matched for hemoglobin (Hb).	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	23-31
19816411-8	2010	Serum hepcidin is elevated in obese women despite iron depletion, suggesting that it is responding to inflammation rather than iron status.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	6-14
19816411-8	2010	Serum hepcidin is elevated in obese women despite iron depletion, suggesting that it is responding to inflammation rather than iron status.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	6-14
19816411-11	2010	However, these findings suggest inflammation may perpetuate this condition by hepcidin-mediated inhibition of dietary iron absorption.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	78-86
20481466-5	2010	Fe-S cluster biogenesis takes place essentially in every tissue of humans, and products of human disease genes, including frataxin, GLRX5, ISCU, and ABCB7, have important roles in the process.	Iron	0-4	glutaredoxin 5	Homo sapiens	132-137
20481466-5	2010	Fe-S cluster biogenesis takes place essentially in every tissue of humans, and products of human disease genes, including frataxin, GLRX5, ISCU, and ABCB7, have important roles in the process.	Iron	0-4	ATP binding cassette subfamily B member 7	Homo sapiens	149-154
24930689-5	2014	Batch experiments indicated that, in the case of low Fe-bearing (STx) and dithionite-reduced clays, the Fe(II) uptake follows the sorption behavior of other divalent transition metals, whereas Fe(II) sorption increased by up to 2 orders of magnitude on the unreduced, Fe(III)-rich montmorillonites (SWy and SWa).	Iron	53-55	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	65-68
20354157-0	2010	Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.	Iron	8-12	leptin	Mus musculus	117-120
20354157-0	2010	Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.	Iron	28-32	leptin	Mus musculus	117-120
23988263-5	2014	Hepcidin is a small liver peptide, that inhibits the cellular macrophage efflux of iron and intestinal iron absorption, binding to ferroportin and inducing its internalization and degradation.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	0-8
23988263-5	2014	Hepcidin is a small liver peptide, that inhibits the cellular macrophage efflux of iron and intestinal iron absorption, binding to ferroportin and inducing its internalization and degradation.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	0-8
23988263-6	2014	In ACD the synthesis of hepcidin is upregulated by increased inflammatory cytokines, causing the two main principal features: the macrophage iron sequestration and the iron-restricted erythropoiesis.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	24-32
23988263-6	2014	In ACD the synthesis of hepcidin is upregulated by increased inflammatory cytokines, causing the two main principal features: the macrophage iron sequestration and the iron-restricted erythropoiesis.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	24-32
24292561-7	2014	The results showed that the content of Hb, SI, SF, EPO, iron content in the liver and spleen were significantly increased in the iron supplement groups (SM-Fe, FeCl3 and FeSO4) compared with the model group (P &lt; 0.05), while TIBC and sTfR were significantly decreased in the iron supplement groups compared with the model group (P &lt; 0.05).	Iron	129-133	erythropoietin	Rattus norvegicus	51-54
24292561-7	2014	The results showed that the content of Hb, SI, SF, EPO, iron content in the liver and spleen were significantly increased in the iron supplement groups (SM-Fe, FeCl3 and FeSO4) compared with the model group (P &lt; 0.05), while TIBC and sTfR were significantly decreased in the iron supplement groups compared with the model group (P &lt; 0.05).	Iron	129-133	erythropoietin	Rattus norvegicus	51-54
24444915-0	2014	Evaluation of different methods for determination of the iron saturation level in bovine lactoferrin.	Iron	57-61	lactotransferrin	Bos taurus	89-100
24444915-3	2014	Numerical values for colour from Chromametry, enthalpy change of denaturation (DeltaHcal) from DSC and molar ellipticities from CD were statistically analysed to evaluate their correlation with the level of iron saturation in Lf.	Iron	207-211	lactotransferrin	Bos taurus	226-228
24444915-4	2014	Linear regression analysis of colour coordinates Chroma (C(*)) and hue (h ) angle on percentage iron saturation level of Lf showed that the values can be used to estimate the iron saturation level.	Iron	96-100	lactotransferrin	Bos taurus	121-123
24444915-4	2014	Linear regression analysis of colour coordinates Chroma (C(*)) and hue (h ) angle on percentage iron saturation level of Lf showed that the values can be used to estimate the iron saturation level.	Iron	175-179	lactotransferrin	Bos taurus	121-123
24444915-5	2014	The DeltaHcal for the iron saturated peak and the CD ellipticities in the 310-340 nm region provided reliable data for the estimation of iron saturation level of Lf up to 75%.	Iron	22-26	lactotransferrin	Bos taurus	162-164
24444915-5	2014	The DeltaHcal for the iron saturated peak and the CD ellipticities in the 310-340 nm region provided reliable data for the estimation of iron saturation level of Lf up to 75%.	Iron	137-141	lactotransferrin	Bos taurus	162-164
24739829-1	2014	BACKGROUND: Hepcidin, a key regulator of iron homeostasis, is increased by iron overload and inflammation while suppressed by hypoxia.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	12-20
24739829-1	2014	BACKGROUND: Hepcidin, a key regulator of iron homeostasis, is increased by iron overload and inflammation while suppressed by hypoxia.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	12-20
24293278-0	2014	Hepcidin production in response to iron is controlled by monocyte-derived humoral factors.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
24293278-1	2014	Hepcidin, which is mainly produced by the liver, is the key regulator in iron homeostasis.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
24345748-10	2014	In summary, at the daily oral Cd exposures chosen for this study, 5 versus 2 Slc39a8 gene copies result in no differences in Cd toxicity but do cause differences in tissue-specific content of Cd, zinc, manganese, calcium, iron, and copper.	Iron	222-226	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	77-84
20408843-6	2010	ABCB7, transporting iron from mitochondria to cytosol and associated with inherited ring sideroblast formation was severely suppressed and expression decreased with differentiation, while increasing in NBM cultures.	Iron	20-24	ATP binding cassette subfamily B member 7	Homo sapiens	0-5
20230820-8	2010	The epidemiological relationship between ARC and ferropenic anemia is explained on the basis that hepcidin, the hormone responsible for the anemia of chronic inflammation, could paradoxically cause intracellular iron overload in the lens by interfering with the proposed ferroportin/ferroxidase-mediated export of iron at the basal side of the anterior lens epithelium.	Iron	212-216	hepcidin antimicrobial peptide	Homo sapiens	98-106
20230820-8	2010	The epidemiological relationship between ARC and ferropenic anemia is explained on the basis that hepcidin, the hormone responsible for the anemia of chronic inflammation, could paradoxically cause intracellular iron overload in the lens by interfering with the proposed ferroportin/ferroxidase-mediated export of iron at the basal side of the anterior lens epithelium.	Iron	314-318	hepcidin antimicrobial peptide	Homo sapiens	98-106
20213069-2	2010	The serum hepcidin level controls the availability of iron for erythropoiesis, and its determination offers new perspectives for the diagnosis of ID in the presence of inflammation.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	10-18
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Iron	159-163	ribonucleotide reductase regulatory subunit M2	Homo sapiens	44-49
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Iron	159-163	ribonucleotide reductase regulatory subunit M2	Homo sapiens	130-135
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Iron	159-163	ribonucleotide reductase regulatory subunit M2	Homo sapiens	130-135
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Iron	276-280	ribonucleotide reductase regulatory subunit M2	Homo sapiens	44-49
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Iron	276-280	ribonucleotide reductase regulatory subunit M2	Homo sapiens	130-135
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Iron	276-280	ribonucleotide reductase regulatory subunit M2	Homo sapiens	130-135
21416977-3	2010	Recent evidences demonstrate that the decrease of hepcidin, a 25-amino acid peptide produced by the hepatocytes, may play a significant role in promoting hepatic iron overload in various chronic liver diseases.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	50-58
21416977-4	2010	Therefore, the supplemental hepcidin therapy may reduce liver iron concentration.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	28-36
21416977-5	2010	Hepcidin or hepcidin-related therapeutics could find a place in the treatment of various iron overload diseases and hepatic fibrosis.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
21416977-5	2010	Hepcidin or hepcidin-related therapeutics could find a place in the treatment of various iron overload diseases and hepatic fibrosis.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	12-20
20609184-4	2010	Hepcidin, a newly discovered key regulator of iron homeostasis, is found to be accumulated in ESRD.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
20609184-5	2010	As it controls iron uptake and release, better reflecting real-time iron demand and availability, hepcidin might become a target in the management of iron deficiency and ESA resistance in dialysis patients.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	98-106
20609184-5	2010	As it controls iron uptake and release, better reflecting real-time iron demand and availability, hepcidin might become a target in the management of iron deficiency and ESA resistance in dialysis patients.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	98-106
20685276-3	2010	JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues in arginine-serine-rich domains of RNA-splicing-related proteins.	Iron	20-24	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
20363739-8	2010	Furthermore, iron depletion in Hjv(-/-) mice decreased hepatic BMP6 mRNA.	Iron	13-17	bone morphogenetic protein 6	Mus musculus	63-67
20363739-11	2010	Our results revealed a close correlation of hepatic BMP6 mRNA expression with hepatic iron-loading.	Iron	86-90	bone morphogenetic protein 6	Mus musculus	52-56
20363739-12	2010	Together, our data indicate that the regulation of hepatic BMP6 expression by iron is independent of HJV, and that expression of HJV in hepatocytes plays an essential role in hepcidin expression by potentiating the BMP6-mediated signaling.	Iron	78-82	bone morphogenetic protein 6	Mus musculus	59-63
20391595-1	2010	Hepcidin is a peptide hormone that functions as a key regulator of mammalian iron metabolism.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
20067561-5	2010	Recently, low levels of the iron-regulatory peptide hepcidin were found to contribute to body iron overload in beta-thalassaemia patients.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	52-60
20067561-5	2010	Recently, low levels of the iron-regulatory peptide hepcidin were found to contribute to body iron overload in beta-thalassaemia patients.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	52-60
20170749-2	2010	Loss of function mutations in humans or experimental deletion in mice result in iron overload consistent with a putative ferroxidase function.	Iron	80-84	ceruloplasmin	Mus musculus	121-132
20356037-1	2010	The inactivation of coliphage MS2 by iron- and copper-catalyzed Fenton systems was studied to assess the importance of this process for virus inactivation in natural systems and during water treatment by advanced oxidation processes.	Iron	37-41	MS2	Homo sapiens	30-33
20170734-0	2010	Seminal plasma of brown trout, Salmo trutta fario (L.) contains a factor able to retain iron at acid pH, typical feature of lactoferrin.	Iron	88-92	lactotransferrin	Bos taurus	124-135
20170734-3	2010	This suggests that the iron binding capacity is determined by a factor having a lactoferrin-like activity.	Iron	23-27	lactotransferrin	Bos taurus	80-91
20364084-0	2010	Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts.	Iron	122-126	glutaredoxin 5	Homo sapiens	0-14
20364084-2	2010	Here we report that GLRX5 is essential for iron-sulfur cluster biosynthesis and the maintenance of normal mitochondrial and cytosolic iron homeostasis in human cells.	Iron	43-47	glutaredoxin 5	Homo sapiens	20-25
24988611-0	2014	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	Iron	92-96	ceruloplasmin	Homo sapiens	1-14
20364084-2	2010	Here we report that GLRX5 is essential for iron-sulfur cluster biosynthesis and the maintenance of normal mitochondrial and cytosolic iron homeostasis in human cells.	Iron	134-138	glutaredoxin 5	Homo sapiens	20-25
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	27-29	glutaredoxin 5	Homo sapiens	3-8
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	72-76	glutaredoxin 5	Homo sapiens	3-8
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	130-134	glutaredoxin 5	Homo sapiens	3-8
20364084-4	2010	In GLRX5-deficient cells, [Fe-S] cluster biosynthesis was impaired, the iron-responsive element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload.	Iron	130-134	glutaredoxin 5	Homo sapiens	3-8
20364084-5	2010	Rescue of patient fibroblasts with the WT GLRX5 gene by transfection or viral transduction reversed a slow growth phenotype, reversed the mitochondrial iron overload, and increased aconitase activity.	Iron	152-156	glutaredoxin 5	Homo sapiens	42-47
24988611-8	2014	The main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein).	Iron	34-38	ceruloplasmin	Homo sapiens	17-30
24988611-8	2014	The main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein).	Iron	110-114	ceruloplasmin	Homo sapiens	17-30
20336713-6	2010	The attenuation of iron-induced augmentation of heme oxygenase-1 was also confirmed in HepG2 cells expressing the core protein.	Iron	19-23	heme oxygenase 1	Homo sapiens	48-64
24988611-8	2014	The main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein).	Iron	110-114	ceruloplasmin	Homo sapiens	17-30
24988613-0	2014	[The role of hepcidin in iron metabolism in inflammatory bowel diseases].	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	13-21
24988613-1	2014	Hepcidin is a 25-amino-acid peptide synthesized predominantly in hepatocytes, which plays an essential role in the regulation of systemic iron homeostasis.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	0-8
24988613-6	2014	The discovery of the biological properties of hepcidin clarified the relationship between iron homeostasis, immune response, and anaemia of chronic disease.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	46-54
20441484-14	2010	With posterior instrumentation alone (CF1 and CF2), C-2 corpectomy reduced bending rigidity in only the FE direction (p &lt; 0.05).	Iron	104-106	complement C2	Homo sapiens	52-55
24332855-5	2013	NRAMP2 is the major iron transporter in cells, and loss of NRAMP2 attenuates intracellular iron transport.	Iron	20-24	solute carrier family 11 member 2	Homo sapiens	0-6
24332855-5	2013	NRAMP2 is the major iron transporter in cells, and loss of NRAMP2 attenuates intracellular iron transport.	Iron	20-24	solute carrier family 11 member 2	Homo sapiens	59-65
20586904-3	2010	The cytokines can also induce iron deficiency by increasing hepcidin production from the liver, which both reduces gastrointestinal iron absorption and reduces iron release from iron stores located in the macrophages and hepatocytes.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	60-68
24376517-8	2013	TMPRSS6 inhibition via decreased STAT5 phosphorylation may be an additional mechanism by which inflammation stimulates hepcidin expression to regulate iron homeostasis and immunity.	Iron	151-155	signal transducer and activator of transcription 5A	Mus musculus	33-38
20586904-3	2010	The cytokines can also induce iron deficiency by increasing hepcidin production from the liver, which both reduces gastrointestinal iron absorption and reduces iron release from iron stores located in the macrophages and hepatocytes.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	60-68
20593115-3	2010	Nowadays, much interest is focused on the mechanisms and regulation of iron metabolism by down-regulation of the hormone hepcidin.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	121-129
24379268-13	2013	Hepcidin is a hormone regulating iron metabolism.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
20593115-7	2010	The genetic variation implicated in iron overload and iron deficiency anaemia, involves mutations in several genes such as HFE, TFR2,HAMP, HJV, Tf and TMPRSS6.	Iron	36-40	transferrin receptor 2	Homo sapiens	128-132
20593115-7	2010	The genetic variation implicated in iron overload and iron deficiency anaemia, involves mutations in several genes such as HFE, TFR2,HAMP, HJV, Tf and TMPRSS6.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	133-137
20144654-7	2010	We report that a defective glutathione system and/or inhibited cellular iron efflux have the neurotoxic capacities to initiate a system characteristic of PD; furthermore, these capacities are greatly enhanced with mutated alpha-synuclein proteins.	Iron	72-76	synuclein alpha	Homo sapiens	222-237
24379268-14	2013	A low level of hepcidin leads to iron overload then to inflammation and liver fibrosis.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	15-23
20065295-0	2010	Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.	Iron	82-86	neogenin	Mus musculus	0-8
20065295-3	2010	Here we provide evidence that neogenin plays a critical role in iron homeostasis by regulation of HJV secretion and bone morphogenetic protein (BMP) signaling.	Iron	64-68	neogenin	Mus musculus	30-38
20065295-4	2010	Livers of neogenin mutant mice exhibit iron overload, low levels of hepcidin, and reduced BMP signaling.	Iron	39-43	neogenin	Mus musculus	10-18
20065295-8	2010	Taken together, our results lead the hypothesis that neogenin regulates iron homeostasis via inhibiting secretion of HJV, an inhibitor of BMP signaling, to enhance BMP signaling and hepcidin expression.	Iron	72-76	neogenin	Mus musculus	53-61
24307367-3	2013	Physicochemical characterizations of the hybrid by using FESEM, TEM, Raman spectroscopy, FTIR, and various control electrochemical experiments revealed that the iron impurity in the MWCNT interacted with the amino functional group of the chitosan polymer and thereby formed an unique complex-like structure ([MWCNT-Fe(III/II):NH2-CHIT]), similar to heme peroxidase with a central Fe(III/II)-redox-active site.	Iron	161-165	chitinase 1	Homo sapiens	330-334
20042286-0	2010	Fenton-like oxidation of reactive black 5 solution using iron-Montmorillonite K10 catalyst.	Iron	57-61	keratin 10	Homo sapiens	78-81
23999124-3	2013	The striatum-specific GTPase share a close homology with Dexras1, which regulates iron trafficking in the neurons when activated though the post-translational modification called s-nitrosylation by nitric oxide (NO).	Iron	82-86	ras related dexamethasone induced 1	Homo sapiens	57-64
20124516-5	2010	These results identify a hepcidin-independent regulation of Fpn that can result in alterations in iron homeostasis.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	25-33
23962819-1	2013	Regulation of iron metabolism in Saccharomyces cerevisiae is achieved at the transcriptional level by low (Aft1 and Aft2) and high iron-sensing (Yap5) transcription factors, and at the post-transcriptional level by mRNA-binding proteins (Cth1 and Cth2).	Iron	14-18	Yap5p	Saccharomyces cerevisiae S288C	145-149
23962819-1	2013	Regulation of iron metabolism in Saccharomyces cerevisiae is achieved at the transcriptional level by low (Aft1 and Aft2) and high iron-sensing (Yap5) transcription factors, and at the post-transcriptional level by mRNA-binding proteins (Cth1 and Cth2).	Iron	14-18	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	238-242
23962819-1	2013	Regulation of iron metabolism in Saccharomyces cerevisiae is achieved at the transcriptional level by low (Aft1 and Aft2) and high iron-sensing (Yap5) transcription factors, and at the post-transcriptional level by mRNA-binding proteins (Cth1 and Cth2).	Iron	14-18	Tis11p	Saccharomyces cerevisiae S288C	247-251
23962819-2	2013	In this review we highlight recent studies unveiling the critical role that iron-sulfur clusters play in control of Aft1/2 and Yap5 activity, as well as the complex relationship between iron homeostasis and thiol redox metabolism.	Iron	76-80	Yap5p	Saccharomyces cerevisiae S288C	127-131
20139087-1	2010	Deletion of two homologous genes, MRS3 and MRS4, that encode mitochondrial iron transporters affects the activity of the vacuolar iron importer Ccc1.	Iron	75-79	Fe(2+) transporter	Saccharomyces cerevisiae S288C	43-47
23962819-3	2013	In addition, new insights into the localization and regulation of Cth1/Cth2 have added another layer of complexity to the cell"s adaptation to iron deficiency.	Iron	143-147	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	66-70
23962819-3	2013	In addition, new insights into the localization and regulation of Cth1/Cth2 have added another layer of complexity to the cell"s adaptation to iron deficiency.	Iron	143-147	Tis11p	Saccharomyces cerevisiae S288C	71-75
23744538-10	2013	Rather, these results indicate that iron consumption for erythropoiesis modulates liver iron content, and ultimately BMP6 and hepcidin.	Iron	36-40	bone morphogenetic protein 6	Mus musculus	117-121
20189278-7	2010	Recent research suggests that these abnormalities in iron balance may be caused by increased levels of the key iron regulatory hormone hepcidin.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	135-143
20189278-7	2010	Recent research suggests that these abnormalities in iron balance may be caused by increased levels of the key iron regulatory hormone hepcidin.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	135-143
20189278-8	2010	This article reviews the pathogenesis of anemia in CKD, the role and regulation of hepcidin in systemic iron homeostasis and the anemia of CKD, and the potential diagnostic and therapeutic implications of these findings.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	83-91
23744538-11	2013	Analysis of the BMP6/SMAD pathway targets showed that inhibitor of DNA binding 1 (ID1) and SMAD7, but not transmembrane serine protease 6 (TMPRSS6), were up-regulated by increased iron availability and thus may be involved in setting the upper limit of hepcidin.	Iron	180-184	bone morphogenetic protein 6	Mus musculus	16-20
23744538-12	2013	CONCLUSION: We provide evidence that under conditions of excessive and effective erythropoiesis, liver iron regulates hepcidin expression through the BMP6/SMAD pathway.	Iron	103-107	bone morphogenetic protein 6	Mus musculus	150-154
23939757-1	2013	Heme oxygenase-1 (HMOX1) is a ubiquitously expressed inducible enzyme that degrades heme to carbon monoxide, biliverdin, and free iron ions.	Iron	130-134	heme oxygenase 1	Homo sapiens	0-16
19650690-4	2010	Systemically, iron levels are regulated through hepcidin-mediated uptake of iron in the duodenum, whereas intracellular free-iron levels are controlled through iron-regulatory proteins (IRPs).	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	48-56
19650690-4	2010	Systemically, iron levels are regulated through hepcidin-mediated uptake of iron in the duodenum, whereas intracellular free-iron levels are controlled through iron-regulatory proteins (IRPs).	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	48-56
19650690-4	2010	Systemically, iron levels are regulated through hepcidin-mediated uptake of iron in the duodenum, whereas intracellular free-iron levels are controlled through iron-regulatory proteins (IRPs).	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	48-56
23939757-1	2013	Heme oxygenase-1 (HMOX1) is a ubiquitously expressed inducible enzyme that degrades heme to carbon monoxide, biliverdin, and free iron ions.	Iron	130-134	heme oxygenase 1	Homo sapiens	18-23
19650690-6	2010	However, the mechanisms of iron homeostasis also are regulated by oxygen availability, with alterations in both hepcidin and IRP activity.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	112-120
19650690-9	2010	In addition, HIF-2alpha translation is controlled by IRP activity, providing another level of interdependence between iron and oxygen homeostasis.	Iron	118-122	endothelial PAS domain protein 1	Homo sapiens	13-23
24371169-1	2013	Fat mass and obesity-associated (FTO) gene codes for a nuclear protein of the AlkB related nonhaem iron and 2-oxoglutaratedependent oxygenase superfamily, and is involved in animal fat deposition and human obesity.	Iron	99-103	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	33-36
21083458-1	2010	The hepatic peptide hormone hepcidin regulates plasma iron concentrations and tissue iron distribution by inhibiting dietary iron absorption and mobilization of iron from stores in macrophages and hepatocytes.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	28-36
21083458-1	2010	The hepatic peptide hormone hepcidin regulates plasma iron concentrations and tissue iron distribution by inhibiting dietary iron absorption and mobilization of iron from stores in macrophages and hepatocytes.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	28-36
21083458-1	2010	The hepatic peptide hormone hepcidin regulates plasma iron concentrations and tissue iron distribution by inhibiting dietary iron absorption and mobilization of iron from stores in macrophages and hepatocytes.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	28-36
21083458-1	2010	The hepatic peptide hormone hepcidin regulates plasma iron concentrations and tissue iron distribution by inhibiting dietary iron absorption and mobilization of iron from stores in macrophages and hepatocytes.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	28-36
23749468-0	2013	CHOP-mediated hepcidin suppression modulates hepatic iron load.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	14-22
21083458-3	2010	Deficient production of hepcidin causes systemic iron overload in hereditary hemochromatosis and iron-loading anemias, such as beta-thalassemia, whereas hepcidin excess contributes to the development of anemia in inflammatory disorders and chronic kidney disease, and may cause erythropoietin resistance.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	24-32
21083458-3	2010	Deficient production of hepcidin causes systemic iron overload in hereditary hemochromatosis and iron-loading anemias, such as beta-thalassemia, whereas hepcidin excess contributes to the development of anemia in inflammatory disorders and chronic kidney disease, and may cause erythropoietin resistance.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	24-32
21083458-4	2010	The Scientific Program on Iron and Heme session at the 51st ASH annual meeting discussed recent advances in understanding hepcidin biology and explored the potential for hepcidin therapeutic applications.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	122-130
21083463-1	2010	The discovery of the peptide hormone hepcidin in 2001 has shed light on the control of iron metabolism.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	37-45
23749468-1	2013	The liver is the central regulator of iron metabolism and accordingly, chronic liver diseases often lead to systemic iron overload due to diminished expression of the iron-regulatory hormone hepcidin.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	191-199
21083463-3	2010	It was found that hepcidin deficiency leads to iron overload, and that its overexpression leads to severe iron-deficiency anemia.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	18-26
21083463-4	2010	Since then, other genes regulating hepcidin expression have been discovered, and defects in them mostly resulted in iron overload.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	35-43
23749468-1	2013	The liver is the central regulator of iron metabolism and accordingly, chronic liver diseases often lead to systemic iron overload due to diminished expression of the iron-regulatory hormone hepcidin.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	191-199
24046195-0	2013	Hepcidin--a well-known iron biomarker with prognostic implications in chronic kidney disease.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
20007134-0	2010	HAMP promoter mutation nc.-153C&gt;T in non p.C282Y homozygous patients with iron overload.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-4
20181752-6	2010	In contrast, the regulation of the zinc transporters ZRT/IRT-LIKE PROTEIN2 (ZIP2), ZIP3, ZIP4, and ZIP9 was dependent on the cellular zinc level, and their regulation by Fe was a secondary effect.	Iron	170-172	zinc transporter 3 precursor	Arabidopsis thaliana	83-87
20113313-0	2010	Chloroplast DnaJ-like proteins 3 and 4 (CDJ3/4) from Chlamydomonas reinhardtii contain redox-active Fe-S clusters and interact with stromal HSP70B.	Iron	100-104	uncharacterized protein	Chlamydomonas reinhardtii	40-46
20113313-7	2010	CDJ3 and CDJ4 proteins could both be expressed in Escherichia coli and had redox-active Fe-S clusters.	Iron	88-92	uncharacterized protein	Chlamydomonas reinhardtii	0-4
20113314-1	2010	Accumulating evidence suggests that hepcidin, a 25-residue peptide hormone, is the master regulator of iron metabolism.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	36-44
20143847-5	2010	Each new bis(imino)pyridine iron dinitrogen compound was screened for the catalytic hydrogenation of ethyl-3-methylbut-2-enoate, and the compound bearing the smallest aryl substituent, [((Me)PDI)Fe(N(2))](2)(mu(2)-N(2)), offers significant improvement over the original ((iPr)PDI)Fe(N(2))(2) pre-catalyst and is one of the most active iron pre-catalysts known.	Iron	28-32	peptidyl arginine deiminase 1	Homo sapiens	191-194
20143847-5	2010	Each new bis(imino)pyridine iron dinitrogen compound was screened for the catalytic hydrogenation of ethyl-3-methylbut-2-enoate, and the compound bearing the smallest aryl substituent, [((Me)PDI)Fe(N(2))](2)(mu(2)-N(2)), offers significant improvement over the original ((iPr)PDI)Fe(N(2))(2) pre-catalyst and is one of the most active iron pre-catalysts known.	Iron	28-32	peptidyl arginine deiminase 1	Homo sapiens	276-279
20007457-0	2010	Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	96-100
20007457-0	2010	Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	105-118
20007457-1	2010	Intestinal iron absorption comprises the coordinated activity of the influx transporter divalent metal transporter 1 (DMT1) and the efflux transporter ferroportin (FPN).	Iron	11-15	solute carrier family 11 member 2	Homo sapiens	118-122
20007457-2	2010	In this work, we studied the movement of DMT1 and FPN between cellular compartments as a function of iron supply.	Iron	101-105	solute carrier family 11 member 2	Homo sapiens	41-45
20007457-5	2010	In Caco-2 cells, the apical-to-basal movement of cyan fluorescent protein-tagged DMT1 was complete 90 min after the addition of iron.	Iron	128-132	solute carrier family 11 member 2	Homo sapiens	81-85
20007457-6	2010	Steady-state membrane localization studies in Caco-2 cells revealed that iron status determined the apical/basolateral membrane distribution of DMT1 and FPN.	Iron	73-77	solute carrier family 11 member 2	Homo sapiens	144-148
20007457-8	2010	Antisense oligonucleotides targeted to DMT1 or FPN inhibited basolateral iron uptake and apical iron efflux, respectively, indicating the participation of DMT1 and FPN in these fluxes.	Iron	73-77	solute carrier family 11 member 2	Homo sapiens	39-43
20007457-8	2010	Antisense oligonucleotides targeted to DMT1 or FPN inhibited basolateral iron uptake and apical iron efflux, respectively, indicating the participation of DMT1 and FPN in these fluxes.	Iron	73-77	solute carrier family 11 member 2	Homo sapiens	155-159
20007457-8	2010	Antisense oligonucleotides targeted to DMT1 or FPN inhibited basolateral iron uptake and apical iron efflux, respectively, indicating the participation of DMT1 and FPN in these fluxes.	Iron	96-100	solute carrier family 11 member 2	Homo sapiens	39-43
20007457-10	2010	These findings suggest a novel mechanism of regulation of intestinal iron absorption based on inward and outward fluxes at both membrane domains, and repositioning of DMT1 and FPN between membrane and intracellular compartments as a function of iron supply.	Iron	245-249	solute carrier family 11 member 2	Homo sapiens	167-171
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	291-298
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	solute carrier family 40 member 1	Homo sapiens	323-330
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	291-298
20392994-1	2010	Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression.	Iron	125-129	solute carrier family 40 member 1	Homo sapiens	323-330
20392994-5	2010	In conclusion, breast cancer cells up-regulate the expression of iron importer genes and down-regulate the expression of iron exporter SLC40A1 to satisfy their increased demand for iron.	Iron	121-125	solute carrier family 40 member 1	Homo sapiens	135-142
20392994-5	2010	In conclusion, breast cancer cells up-regulate the expression of iron importer genes and down-regulate the expression of iron exporter SLC40A1 to satisfy their increased demand for iron.	Iron	121-125	solute carrier family 40 member 1	Homo sapiens	135-142
20393584-2	2010	Iron concentrations can rise to toxic levels in mitochondria of excitable cells, often leaving the cytosol iron-depleted, in some forms of neurodegeneration with brain accumulation (NBIA) or following mutations in genes associated with mitochondrial functions, such as ABCB7 in X-linked sideroblastic anemia with ataxia (XLSA/A) or the genes encoding frataxin in Friedreich"s ataxia (FRDA).	Iron	0-4	ATP binding cassette subfamily B member 7	Homo sapiens	269-274
20008079-1	2010	Budding yeast (Saccharomyces cerevisiae) responds to iron deprivation both by Aft1-Aft2-dependent transcriptional activation of genes involved in cellular iron uptake and by Cth1-Cth2-specific degradation of certain mRNAs coding for iron-dependent biosynthetic components.	Iron	53-57	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	174-178
20008079-1	2010	Budding yeast (Saccharomyces cerevisiae) responds to iron deprivation both by Aft1-Aft2-dependent transcriptional activation of genes involved in cellular iron uptake and by Cth1-Cth2-specific degradation of certain mRNAs coding for iron-dependent biosynthetic components.	Iron	53-57	Tis11p	Saccharomyces cerevisiae S288C	179-183
20008079-6	2010	As another example, decreased mRNA levels of the cytochrome c-encoding CYC1 gene under iron-limiting conditions involve heme-dependent transcriptional regulation via the Hap1 transcription factor.	Iron	87-91	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	71-75
20008079-6	2010	As another example, decreased mRNA levels of the cytochrome c-encoding CYC1 gene under iron-limiting conditions involve heme-dependent transcriptional regulation via the Hap1 transcription factor.	Iron	87-91	Hap1p	Saccharomyces cerevisiae S288C	170-174
19833632-1	2010	Expression of hepcidin, the key hormone governing iron transport, is reduced by anemia in a manner which appears dependent on increased bone marrow activity.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	14-22
19833632-6	2010	These human studies confirm the importance of a rapidly responsive marrow-hepcidin axis in regulating iron supply in vivo, and suggest that this axis is regulated by factors other than circulating iron, soluble transferrin receptor or growth differentiation factor-15.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	74-82
19937651-3	2010	We describe a large pedigree with a novel SLC40A1 mutation and, through in vitro analysis, elucidate the associated molecular mechanism of iron overload.	Iron	139-143	solute carrier family 40 member 1	Homo sapiens	42-49
19937651-7	2010	A novel SLC40A1 mutation p.R489K segregated with iron overload in a family with clinical and histopathological signs of macrophage-type ferroportin disease.	Iron	49-53	solute carrier family 40 member 1	Homo sapiens	8-15
20099297-4	2010	Our study demonstrated a profound protective effect of Lac in a murine model of AILI, which was not dependent on its iron-binding ability, inhibition of acetaminophen (APAP) metabolism, or a direct cytoprotective effect on hepatocytes.	Iron	117-121	lactotransferrin	Mus musculus	55-58
20025906-5	2010	Conserved residues in the predicted transmembrane domains II, IV, V and VII of LIT1 are essential for iron transport in yeast, including histidines that were proposed to function as metal ligands in ZIP transporters.	Iron	102-106	phosphatidylinositol 4,5-bisphosphate-binding protein	Saccharomyces cerevisiae S288C	79-83
20025906-9	2010	Mutagenesis revealed two motifs within region II, HGHQH and TPPRDM, that are independently required for iron transport by LIT1.	Iron	104-108	phosphatidylinositol 4,5-bisphosphate-binding protein	Saccharomyces cerevisiae S288C	122-126
20349360-2	2010	The physiological significance of Lf is related to non-specific immune defence against pathogens, immunomodulatory activity, iron homeostasis, antioxidant properties and regulation of cell growth.	Iron	125-129	lactotransferrin	Bos taurus	34-36
20102179-1	2010	Levels of the peptide hormone hepcidin negatively correlate with systemic iron status and are increased in disorders in which iron metabolism is secondarily disregulated, such as the anemia of chronic disease.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	30-38
20102179-1	2010	Levels of the peptide hormone hepcidin negatively correlate with systemic iron status and are increased in disorders in which iron metabolism is secondarily disregulated, such as the anemia of chronic disease.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	30-38
19996315-8	2010	These surface residues are close to the iron-sulfur center of Fd and the HY2 active site, implying that the interaction promotes direct electron transfer from the Fd to HY2-bound BV.	Iron	40-44	phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2)	Arabidopsis thaliana	73-76
19996315-8	2010	These surface residues are close to the iron-sulfur center of Fd and the HY2 active site, implying that the interaction promotes direct electron transfer from the Fd to HY2-bound BV.	Iron	40-44	phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2)	Arabidopsis thaliana	169-172
20007325-2	2010	Because plant ferritin possesses both a ferroxidase site and a ferrihydrite nucleation site, it is a suitable model for studying the mechanism of iron storage in ferritin.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	14-22
20007325-2	2010	Because plant ferritin possesses both a ferroxidase site and a ferrihydrite nucleation site, it is a suitable model for studying the mechanism of iron storage in ferritin.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	162-170
19956996-0	2010	Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site.	Iron	85-89	deoxyhypusine monooxygenase	Saccharomyces cerevisiae S288C	75-79
19956996-7	2010	The separation of iron-free and iron-bound forms by gel filtration and native electrophoresis suggests differences in Lia1 tertiary structure related to the iron binding.	Iron	18-22	deoxyhypusine monooxygenase	Saccharomyces cerevisiae S288C	118-122
19956996-7	2010	The separation of iron-free and iron-bound forms by gel filtration and native electrophoresis suggests differences in Lia1 tertiary structure related to the iron binding.	Iron	32-36	deoxyhypusine monooxygenase	Saccharomyces cerevisiae S288C	118-122
19956996-7	2010	The separation of iron-free and iron-bound forms by gel filtration and native electrophoresis suggests differences in Lia1 tertiary structure related to the iron binding.	Iron	32-36	deoxyhypusine monooxygenase	Saccharomyces cerevisiae S288C	118-122
19956996-10	2010	Loss of tertiary contacts upon iron displacement led to an elongated conformation of Lia1, in which the N- and C-terminal domains are no longer in close proximity to guarantee the proper orientation of the active groups within the active site pocket.	Iron	31-35	deoxyhypusine monooxygenase	Saccharomyces cerevisiae S288C	85-89
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	134-142
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	134-142
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	134-142
20019408-2	2010	Hepcidin is an iron regulatory peptide that is synthesized in the liver to suppress iron absorption and utilization.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
20019408-2	2010	Hepcidin is an iron regulatory peptide that is synthesized in the liver to suppress iron absorption and utilization.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
20019408-12	2010	CONCLUSIONS: Serum hepcidin-25 concentrations were regulated by iron storage and erythropoiesis but not by IL-6 in CHF patients with anemia.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	19-27
23418677-5	2013	Both Hp1-1 and Hp2-2 attenuate Hb-induced blood pressure response and renal iron deposition.	Iron	76-80	chromobox 5	Homo sapiens	5-10
20158466-0	2010	Iron leads to memory impairment that is associated with a decrease in acetylcholinesterase pathways.	Iron	0-4	acetylcholinesterase	Rattus norvegicus	70-90
20158466-11	2010	Rats given iron showed a decreased AChE activity in the striatum when compared to controls.	Iron	11-15	acetylcholinesterase	Rattus norvegicus	35-39
20104510-0	2010	Biting the iron bullet: endoplasmic reticulum stress adds the pain of hepcidin to chronic liver disease.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	70-78
24055409-3	2013	Transferrin receptor type 2 (TFR2) is a protein expressed on cell membrane and involved in the cellular iron uptake.	Iron	104-108	transferrin receptor 2	Homo sapiens	0-27
20018808-8	2010	Expression of an alternative route of Fe absorption, solute carrier family 39 member 14 (SLC39A14), was downregulated in the intestine of pigs fed high dietary Fe.	Iron	160-162	zinc transporter ZIP14	Sus scrofa	89-97
20018808-10	2010	Our findings indicate new roles in Fe metabolism for several mineral metabolism-associated genes and that some of these genes, such as SLC39A14, may be regulated in response to dietary Fe in pigs.	Iron	185-187	zinc transporter ZIP14	Sus scrofa	135-143
24055409-3	2013	Transferrin receptor type 2 (TFR2) is a protein expressed on cell membrane and involved in the cellular iron uptake.	Iron	104-108	transferrin receptor 2	Homo sapiens	29-33
23940031-0	2013	Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).	Iron	197-201	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	146-151
19925812-1	2010	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron and bilirubin.	Iron	147-151	heme oxygenase 1	Homo sapiens	0-16
19925812-1	2010	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron and bilirubin.	Iron	147-151	heme oxygenase 1	Homo sapiens	18-22
24124495-1	2013	Mass spectrometry (MS)-based assays for the quantification of the iron regulatory hormone hepcidin are pivotal to discriminate between the bioactive 25-amino acid form that can effectively block the sole iron transporter ferroportin and other naturally occurring smaller isoforms without a known role in iron metabolism.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	90-98
20164445-4	2010	In ATM3 insertion mutants of Arabidopsis thaliana, the activities of nitrate reductase and sulfite oxidase were decreased to approximately 50%, whereas the activities of xanthine dehydrogenase and aldehyde oxidase, whose activities also depend on iron-sulfur clusters, were virtually undetectable.	Iron	247-251	aldehyde oxidase 1	Arabidopsis thaliana	197-213
19921836-0	2010	Comparative study on iron release from soybean (Glycine max) seed ferritin induced by anthocyanins and ascorbate.	Iron	21-25	ferritin-1, chloroplastic	Glycine max	66-74
24124495-1	2013	Mass spectrometry (MS)-based assays for the quantification of the iron regulatory hormone hepcidin are pivotal to discriminate between the bioactive 25-amino acid form that can effectively block the sole iron transporter ferroportin and other naturally occurring smaller isoforms without a known role in iron metabolism.	Iron	204-208	hepcidin antimicrobial peptide	Homo sapiens	90-98
24286116-12	2013	CONCLUSIONS: Hepcidin-mediated iron metabolism may contribute to the pathogenesis of RA-related anemia.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	13-21
20467559-8	2010	The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	104-112
20631898-4	2010	Hepcidin is a key regulator of iron absorption and recycling and is itself regulated by erythropoiesis.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
23800229-2	2013	The mitochondrial carrier family members Mrs3 and Mrs4 (homologues of vertebrate mitoferrin) function in organellar iron supply, yet other low efficiency transporters may exist.	Iron	116-120	Fe(2+) transporter	Saccharomyces cerevisiae S288C	50-54
23787363-0	2013	Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).	Iron	0-4	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	123-128
19846751-2	2010	Ferroportin protein is a multitransmembrane domain iron transporter, responsible for iron export from cells, which, in turn, is regulated by the peptide hormone hepcidin.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	161-169
23787363-0	2013	Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).	Iron	0-4	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	133-140
19846751-3	2010	Mutations in the ferroportin gene may affect either regulation of the protein"s transporter function or the ability of hepcidin to regulate iron efflux.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	119-127
23787363-0	2013	Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).	Iron	76-80	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	123-128
23787363-8	2013	Effects similar to iron deficiency were generated by siRNA knockdown of either splicing factor U2AF(65) or Fe(II)- and 2-oxoglutarate-dependent dioxygenase Jumonji domain-containing protein 6 (Jmjd6), which interacts with U2AF(65) by lysyl-hydroxylation.	Iron	19-23	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	95-103
23787363-8	2013	Effects similar to iron deficiency were generated by siRNA knockdown of either splicing factor U2AF(65) or Fe(II)- and 2-oxoglutarate-dependent dioxygenase Jumonji domain-containing protein 6 (Jmjd6), which interacts with U2AF(65) by lysyl-hydroxylation.	Iron	19-23	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	95-102
23787363-9	2013	Based on these results, we propose that the availability of iron, a co-factor of Jmjd6, modulates U2AF(65)-lysyl-hydroxylation.	Iron	60-64	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	81-86
20648931-19	2010	iron over oral iron is that it may bypass hepcidin actions by directly loading transferrin and making iron available to macrophages.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	42-50
20648931-19	2010	iron over oral iron is that it may bypass hepcidin actions by directly loading transferrin and making iron available to macrophages.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	42-50
23787363-9	2013	Based on these results, we propose that the availability of iron, a co-factor of Jmjd6, modulates U2AF(65)-lysyl-hydroxylation.	Iron	60-64	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	98-106
20648931-19	2010	iron over oral iron is that it may bypass hepcidin actions by directly loading transferrin and making iron available to macrophages.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	42-50
23787995-11	2013	Iron staining indicated precipitations of the erythrocyte-derived pigment hemosiderin in kidney tubules of gclm(-/-) mice and none in gclm(+/+) controls.	Iron	0-4	glutamate-cysteine ligase, modifier subunit	Mus musculus	107-111
24018561-2	2013	The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity.	Iron	77-81	ceruloplasmin	Mus musculus	35-46
23903534-2	2013	The aim of this study was to examine the relationship between the inflammation induced by a 100 km run and the level of hepcidin, which is a hormone regulating iron metabolism.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	120-128
24137020-2	2013	Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	88-96
24137020-2	2013	Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	88-96
24137020-3	2013	Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
24137020-3	2013	Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
24137020-3	2013	Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
23496756-4	2013	The maize ys3 mutant, which cannot release phytosiderophores, did not improve Fe nutrition of peanut, whereas the maize ys1 mutant, which can release phytosiderophores, prevented Fe deficiency, indicating an important role of phytosiderophores in improving the Fe nutrition of intercropped peanut.	Iron	179-181	iron-phytosiderophore transporter yellow stripe 1	Zea mays	120-123
24066281-11	2013	Nramp1 and Nramp2 localization in distinct compartments suggests that both proteins synergistically regulate iron homeostasis.	Iron	109-113	solute carrier family 11 member 2	Homo sapiens	11-17
23798505-1	2013	Fe-doped Mnx Oy with hierarchical porosity is prepared from a nanocasting technique using amine-functionalized bromomethylated poly (2,6-dimethyl-1,4-phenylene oxide) (BPPO) membranes as the sacrificial template.	Iron	0-2	keratin 86	Homo sapiens	9-12
24252754-0	2013	The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer"s disease.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	38-46
24252754-5	2013	By histochemistry, hepcidin and ferroportin were widely distributed in the normal human brain and co-localised in neurons and astrocytes suggesting a role in regulating iron release.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	19-27
23731455-1	2013	OBJECTIVES: Hepcidin plays a regulatory role in systemic iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	12-20
23376471-2	2013	The elevated iron levels observed in the substantia nigra of PD subjects have been suggested to incite the generation of reactive oxygen species and intracellular alpha-synuclein aggregation, terminating in the oxidative neuronal destruction of this brain area.	Iron	13-17	synuclein alpha	Homo sapiens	163-178
23540794-0	2013	The evaluation of iron overload through hepcidin level and its related factors in myelodysplastic syndromes.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	40-48
23540794-1	2013	We chose hepcidin and its related factors as evaluating indicators to determine the degrees of iron overload in myelodysplastic syndromes (MDS) patients.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	9-17
23540794-13	2013	Liver iron concentration (LIC) measured by MRI T2* had a closer correlation (r = 0.582, P &lt; 0.001) to hepcidin than serum ferritin, by stepwise regression.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	105-113
23540794-18	2013	It seems that hepcidin with CRP and LIC measured by MRI T2* are potential indicators of iron overload in MDS patients.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	14-22
23219355-3	2013	We hypothesized that hepcidin is significantly elevated in anemic CD patients and that hepcidin may cause iron restriction and, therefore, mediate ACD.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	87-95
23179554-4	2013	This discovery highlighted the molecular function of NFU1 as an iron-sulfur(Fe-S) cluster protein necessary for lipoic acid biosynthesis and respiratory chain complexes activities.	Iron	64-68	NFU1 iron-sulfur cluster scaffold	Homo sapiens	53-57
23179554-4	2013	This discovery highlighted the molecular function of NFU1 as an iron-sulfur(Fe-S) cluster protein necessary for lipoic acid biosynthesis and respiratory chain complexes activities.	Iron	76-78	NFU1 iron-sulfur cluster scaffold	Homo sapiens	53-57
23794717-11	2013	Taken together, this suggests that there might be other, yet unknown, serum hepcidin independent mechanisms which play a role in the association of HFE and TMPRSS6 variants with serum iron parameters.	Iron	184-188	hepcidin antimicrobial peptide	Homo sapiens	76-84
22968710-5	2013	Although hepcidin, a small circulating peptide produced by the liver, has been found to be the key regulator of iron trafficking, molecular pathways of iron sensing that control iron metabolism and hepcidin production are still incompletely understood.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	9-17
22968710-5	2013	Although hepcidin, a small circulating peptide produced by the liver, has been found to be the key regulator of iron trafficking, molecular pathways of iron sensing that control iron metabolism and hepcidin production are still incompletely understood.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	9-17
22968710-5	2013	Although hepcidin, a small circulating peptide produced by the liver, has been found to be the key regulator of iron trafficking, molecular pathways of iron sensing that control iron metabolism and hepcidin production are still incompletely understood.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	198-206
22968710-5	2013	Although hepcidin, a small circulating peptide produced by the liver, has been found to be the key regulator of iron trafficking, molecular pathways of iron sensing that control iron metabolism and hepcidin production are still incompletely understood.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	9-17
22968710-5	2013	Although hepcidin, a small circulating peptide produced by the liver, has been found to be the key regulator of iron trafficking, molecular pathways of iron sensing that control iron metabolism and hepcidin production are still incompletely understood.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	198-206
23082485-3	2010	The hepatic peptide; hepcidin is a key regulator of iron metabolism in mammals.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	21-29
23801774-9	2013	RESULTS: CV1-FHC fibroblasts (vs CV1 fibroblasts) showed enhanced iron uptake (1.8 mmol +- 0.5 x 10(-8) vs 0.9 mmol +- 0.5 x 10(-8); P &lt; .05), retention (1.6 mmol +- 0.5 x 10(-8) vs 0.5 mmol +- 0.5 x 10(-8), P &lt; .05), and cell density-dependent R2 contrast.	Iron	66-70	ferritin heavy chain 1	Homo sapiens	13-16
23082485-4	2010	The present study aimed to determine the relationship between hepcidin expression and iron status in beta-thalassemia patients with hepatitis C virus infection.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	62-70
23082485-7	2010	Result showed remarkable decrease of serum and liver hepcidin mRNA expression in thalassemic patients as compared to controls, and showed a positive correlation with hemoglobin concentration, but negatively correlated with serum ferritin level and hepatic iron index (HII).	Iron	256-260	hepcidin antimicrobial peptide	Homo sapiens	53-61
23082485-11	2010	These results suggest a possible role of hepcidin expression in iron overload in beta-thalassemia major, consequent disease progression and development of liver fibrosis.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	41-49
23863217-3	2013	The VCS spectra revealed for the first time several low-frequency heme modes that are sensitive to cyt c unfolding: gamma(a) (~50 cm(-1)), gamma(b) (~80 cm(-1)), gamma(c) (~100 cm(-1)), and nu(s)(His-Fe-His) at 205 cm(-1).	Iron	200-202	cytochrome c, somatic	Equus caballus	99-104
19837170-1	2010	Transferrin is important in iron metabolism and has been reported to be involved in disease defence responses after bacterial infection.	Iron	28-32	transferrin	Ictalurus punctatus	0-11
20686294-3	2010	Aceruloplasminemia is caused by mutations in the ceruloplasmin gene, which results in the absence of serum ceruloplasmin and iron overload in the brain, liver, pancreas and other organ tissues.	Iron	125-129	ceruloplasmin	Homo sapiens	1-14
23814049-1	2013	Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins.	Iron	78-82	ATPase copper transporting alpha	Rattus norvegicus	167-172
20686294-3	2010	Aceruloplasminemia is caused by mutations in the ceruloplasmin gene, which results in the absence of serum ceruloplasmin and iron overload in the brain, liver, pancreas and other organ tissues.	Iron	125-129	ceruloplasmin	Homo sapiens	49-62
23814049-1	2013	Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins.	Iron	123-127	ATPase copper transporting alpha	Rattus norvegicus	167-172
20858976-4	2010	Furthermore, iron and copper chelators, as well as the antioxidants glutathione and trolox, were neuroprotective on neuroblastoma cells and mouse hippocampal neurons challenged with Abeta fibrils.	Iron	13-17	amyloid beta (A4) precursor protein	Mus musculus	182-187
23814049-2	2013	It was shown previously that an intestinal copper transporter (Atp7a) was co-regulated with iron transport-related genes by a hypoxia-inducible transcription factor, Hif2alpha.	Iron	92-96	ATPase copper transporting alpha	Rattus norvegicus	63-68
23814049-3	2013	In the current study, we sought to test the role of Sp1 in transcriptional regulation of Atp7a expression during iron deprivation/hypoxia.	Iron	113-117	ATPase copper transporting alpha	Rattus norvegicus	89-94
23814049-9	2013	Understanding regulation of Atp7a expression may help further clarify the physiological role of copper in the maintenance of iron homeostasis.	Iron	125-129	ATPase copper transporting alpha	Rattus norvegicus	28-33
20182641-1	2010	We have reported three Fe-deficiency-responsive elements (FEREs), FOX1, ATX1, and FEA1, all of which are positive regulatory elements in response to iron deficiency in Chlamydomonas reinhardtii.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	82-86
23714423-2	2013	Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. We show in this study that HO-1 expression is reduced in PBMCs of MS patients and that during exacerbation of the disease there is a significant downregulation of this enzyme.	Iron	167-171	heme oxygenase 1	Homo sapiens	0-16
19918260-5	2010	The mechanism underlying this excessive absorption of iron is a sensing defect caused by the reduced formation of hepcidin, the master regulator of iron homeostasis, as a consequence of mutations in the genes encoding several membrane-bound signaling molecules present on hepatocytes.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	114-122
19918260-5	2010	The mechanism underlying this excessive absorption of iron is a sensing defect caused by the reduced formation of hepcidin, the master regulator of iron homeostasis, as a consequence of mutations in the genes encoding several membrane-bound signaling molecules present on hepatocytes.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	114-122
23714423-2	2013	Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. We show in this study that HO-1 expression is reduced in PBMCs of MS patients and that during exacerbation of the disease there is a significant downregulation of this enzyme.	Iron	167-171	heme oxygenase 1	Homo sapiens	18-22
20415234-2	2010	Cellular iron status can be determined by the recently available method of measuring the reticulocyte hemoglobin equivalent (RET-He).	Iron	9-13	ret proto-oncogene	Homo sapiens	125-128
23714423-2	2013	Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. We show in this study that HO-1 expression is reduced in PBMCs of MS patients and that during exacerbation of the disease there is a significant downregulation of this enzyme.	Iron	167-171	heme oxygenase 1	Homo sapiens	207-211
23836059-0	2013	IL-22 regulates iron availability in vivo through the induction of hepcidin.	Iron	16-20	interleukin 22	Mus musculus	0-5
19681654-1	2010	Hepcidin, a key regulator of iron metabolism, plays a crucial role in the pathogenesis of anemia of chronic disease.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
19681654-8	2010	We suggest that acute inflammatory changes could affect the regulation of hepcidin expression in subcutaneous adipose tissue and thus possibly contribute to inflammation-induced systemic changes of iron metabolism.	Iron	198-202	hepcidin antimicrobial peptide	Homo sapiens	74-82
23836059-8	2013	Injection of mice with exogenous mouse IgG1 Fc fused to the N terminus of mouse IL-22 (Fc-IL-22), an IL-22R agonist with prolonged and enhanced functional potency, induced hepcidin production, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant increase in iron accumulation within the spleen.	Iron	241-245	interleukin 22	Mus musculus	80-85
23836059-8	2013	Injection of mice with exogenous mouse IgG1 Fc fused to the N terminus of mouse IL-22 (Fc-IL-22), an IL-22R agonist with prolonged and enhanced functional potency, induced hepcidin production, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant increase in iron accumulation within the spleen.	Iron	241-245	interleukin 22	Mus musculus	87-95
23836059-8	2013	Injection of mice with exogenous mouse IgG1 Fc fused to the N terminus of mouse IL-22 (Fc-IL-22), an IL-22R agonist with prolonged and enhanced functional potency, induced hepcidin production, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant increase in iron accumulation within the spleen.	Iron	298-302	interleukin 22	Mus musculus	80-85
20592808-6	2010	Since MAR1 overexpression lines exhibit various iron starvation phenotypes, we propose that MAR1 transports an iron chelation molecule that is mimicked specifically by aminoglycoside antibiotics, and this facilitates their entry into the chloroplast.	Iron	48-52	retrotransposon Gag like 1	Homo sapiens	6-10
20592808-6	2010	Since MAR1 overexpression lines exhibit various iron starvation phenotypes, we propose that MAR1 transports an iron chelation molecule that is mimicked specifically by aminoglycoside antibiotics, and this facilitates their entry into the chloroplast.	Iron	48-52	retrotransposon Gag like 1	Homo sapiens	92-96
23836059-8	2013	Injection of mice with exogenous mouse IgG1 Fc fused to the N terminus of mouse IL-22 (Fc-IL-22), an IL-22R agonist with prolonged and enhanced functional potency, induced hepcidin production, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant increase in iron accumulation within the spleen.	Iron	298-302	interleukin 22	Mus musculus	87-95
20592808-6	2010	Since MAR1 overexpression lines exhibit various iron starvation phenotypes, we propose that MAR1 transports an iron chelation molecule that is mimicked specifically by aminoglycoside antibiotics, and this facilitates their entry into the chloroplast.	Iron	111-115	retrotransposon Gag like 1	Homo sapiens	6-10
23836059-11	2013	Taken together, these data suggest that exogenous IL-22 regulates hepcidin production to physiologically influence iron usage.	Iron	115-119	interleukin 22	Mus musculus	50-55
20592808-6	2010	Since MAR1 overexpression lines exhibit various iron starvation phenotypes, we propose that MAR1 transports an iron chelation molecule that is mimicked specifically by aminoglycoside antibiotics, and this facilitates their entry into the chloroplast.	Iron	111-115	retrotransposon Gag like 1	Homo sapiens	92-96
23678007-2	2013	Recently, however, attention has returned to the gut based on the finding that hypoxia inducible factor-2 (HIF-2alpha) regulates the expression of key genes that contribute to iron absorption.	Iron	176-180	endothelial PAS domain protein 1	Homo sapiens	107-117
19647938-7	2009	PC1, with a high contribution of Ni, Cr, Fe, Mn and clay content was hypothesized as lithogenic component and PC2, with high loadings for the seven discerning variables (Cu, As, Cd, OM, P, K and total N), was considered as an agrogenic component.	Iron	41-43	polycystin 1, transient receptor potential channel interacting	Homo sapiens	0-3
23707854-3	2013	We hypothesized that hepatic injury was related to disrupted iron homeostasis triggered by the interaction of Fas-ligand, expressed on activated T cells, with Fas on hepatocytes.	Iron	61-65	Fas ligand	Homo sapiens	110-120
19828835-10	2009	Transfection with a hTFR2 plasmid increased TFR2 protein expression, causing a 15-20% increase in iron uptake and ferritin levels.	Iron	98-102	transferrin receptor 2	Homo sapiens	20-25
19828835-10	2009	Transfection with a hTFR2 plasmid increased TFR2 protein expression, causing a 15-20% increase in iron uptake and ferritin levels.	Iron	98-102	transferrin receptor 2	Homo sapiens	21-25
23985001-1	2013	Hereditary hemochromatosis is an inherited iron overload disorder caused by inappropriately low hepcidin secretion leading to increased duodenal absorption of dietary iron, most commonly in C282Y homozygous individuals.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	96-104
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	5-9	solute carrier family 40 member 1	Homo sapiens	210-223
20358346-6	2009	The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level.	Iron	22-26	myeloperoxidase	Rattus norvegicus	52-67
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	5-9	solute carrier family 40 member 1	Homo sapiens	225-229
20358346-6	2009	The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level.	Iron	22-26	myeloperoxidase	Rattus norvegicus	69-72
20358346-6	2009	The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level.	Iron	22-26	myeloperoxidase	Rattus norvegicus	171-174
23991927-3	2013	Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	263-271
23769363-1	2013	Lactoferrin (LF) is known as an iron-binding antimicrobial protein present in exocrine secretions such as milk and releases the potent antimicrobial peptide lactoferricin (LFcin) by hydrolysis with pepsin.	Iron	32-36	lactotransferrin	Bos taurus	0-11
19855093-9	2009	In addition to its well known iron storage role, FTH1 has been shown to protect the nucleus from oxidative damage.	Iron	30-34	ferritin heavy chain 1	Homo sapiens	49-53
23769363-1	2013	Lactoferrin (LF) is known as an iron-binding antimicrobial protein present in exocrine secretions such as milk and releases the potent antimicrobial peptide lactoferricin (LFcin) by hydrolysis with pepsin.	Iron	32-36	lactotransferrin	Bos taurus	13-15
20030959-3	2009	Hepcidin, a kind of protein secreted by liver is considered to be the hormone regulating iron metabolism.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
20030959-9	2009	In this article, the hepcidin and its relation to iron metabolism and anemia in chronic disease are reviewed.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	21-29
23759098-1	2013	The nicotianamine synthase (NAS) enzymes catalyze the formation of nicotianamine (NA), a non-proteinogenic amino acid involved in iron homeostasis.	Iron	130-134	nicotianamine synthase	Arabidopsis thaliana	4-26
23759098-1	2013	The nicotianamine synthase (NAS) enzymes catalyze the formation of nicotianamine (NA), a non-proteinogenic amino acid involved in iron homeostasis.	Iron	130-134	nicotianamine synthase	Arabidopsis thaliana	28-31
23807042-1	2013	BACKGROUND: Hepcidin is a key regulator of iron metabolism.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	12-20
19728742-5	2009	The pronounced structural differences at three regions between hp53R2 and hRRM2 highlight the possible regulatory role in iron assimilation and help explain previously observed physical and biochemical differences in the mobility and accessibility of the radical iron center, as well as radical transfer pathways between the two enzymes.	Iron	122-126	ribonucleotide reductase regulatory subunit M2	Homo sapiens	74-79
19728742-5	2009	The pronounced structural differences at three regions between hp53R2 and hRRM2 highlight the possible regulatory role in iron assimilation and help explain previously observed physical and biochemical differences in the mobility and accessibility of the radical iron center, as well as radical transfer pathways between the two enzymes.	Iron	263-267	ribonucleotide reductase regulatory subunit M2	Homo sapiens	74-79
23807042-3	2013	The synthesis of hepcidin is upregulated by high iron stores and inflammation.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	17-25
23807042-5	2013	Our aim was to describe the relationship between hepcidin and other parameters of iron metabolism, erythropoiesis, and inflammation.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	49-57
23796308-1	2013	Human NFU has been implicated in the formation of inorganic sulfide required for cellular iron-sulfur cluster biosynthesis.	Iron	90-94	NFU1 iron-sulfur cluster scaffold	Homo sapiens	6-9
19740974-0	2009	Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	7-15
19740974-0	2009	Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	171-179
19740974-1	2009	BACKGROUND: Plasma hepcidin appears to be a major regulator of iron absorption and homeostasis, but there are few data in humans.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	19-27
19740974-2	2009	OBJECTIVES: With the use of iron stable isotopes, we aimed to determine whether circulating hepcidin predicts dietary iron bioavailability, to quantify the amount of absorbed iron after oral iron loading, and to measure the plasma hepcidin response.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	92-100
19740974-2	2009	OBJECTIVES: With the use of iron stable isotopes, we aimed to determine whether circulating hepcidin predicts dietary iron bioavailability, to quantify the amount of absorbed iron after oral iron loading, and to measure the plasma hepcidin response.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	92-100
19740974-2	2009	OBJECTIVES: With the use of iron stable isotopes, we aimed to determine whether circulating hepcidin predicts dietary iron bioavailability, to quantify the amount of absorbed iron after oral iron loading, and to measure the plasma hepcidin response.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	92-100
23888164-7	2013	Comparing the responses to Fe deficiency in leaves to that in roots confirmed subgroup 1b bHLH transcription factors and POPEYE/BRUTUS as important regulators of Fe homeostasis in both leaf and root cells, and indicated six novel players with putative roles in Fe homeostasis that were highly expressed in leaves and roots and greatly induced by Fe deficiency.	Iron	27-29	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	121-127
19709084-0	2009	A novel missense mutation in SLC40A1 results in resistance to hepcidin and confirms the existence of two ferroportin-associated iron overload diseases.	Iron	128-132	solute carrier family 40 member 1	Homo sapiens	29-36
19709084-7	2009	These findings confirm that certain ferroportin mutations compromise the activity of hepcidin in iron homeostasis, mimicking hepcidin deficiency as described in all types of hemochromatosis.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	85-93
23758282-0	2013	Conserved hydrogen bonding networks of MitoNEET tune Fe-S cluster binding and structural stability.	Iron	53-57	CDGSH iron sulfur domain 1	Homo sapiens	39-47
19729324-2	2009	Among these is a second transferrin receptor (TfR2) that seems to play a key role in the regulation of iron homeostasis.	Iron	103-107	transferrin receptor 2	Homo sapiens	46-50
19729219-0	2009	Reduced serum hepcidin levels in patients with chronic hepatitis C. BACKGROUND/AIMS: Patients with chronic hepatitis C (CHC) often have increased liver iron, a condition associated with reduced sustained response to antiviral therapy, more rapid progression to cirrhosis, and development of hepatocellular carcinoma.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	14-22
23656728-1	2013	beta-Thalassemia major causes ineffective erythropoiesis and chronic anemia and is associated with iron overload due to both transfused iron and increased iron absorption, the latter mediated by suppression of the iron-regulatory hormone hepcidin.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	238-246
19729219-1	2009	The hepatic hormone hepcidin is the major regulator of iron metabolism and inhibits iron absorption and recycling from erythrophagocytosis.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	20-28
19729219-1	2009	The hepatic hormone hepcidin is the major regulator of iron metabolism and inhibits iron absorption and recycling from erythrophagocytosis.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	20-28
19729219-2	2009	Hepcidin decrease is a possible pathophysiological mechanism of iron overload in CHC, but studies in humans have been hampered so far by the lack of reliable quantitative assays for the 25-amino acid bioactive peptide in serum (s-hepcidin).	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
19729219-6	2009	In CHC patients, s-hepcidin significantly correlated with serum ferritin and histological total iron score, but not with s-interleukin-6.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	19-27
19729219-9	2009	CONCLUSIONS: These results, together with very recent studies in animal and cellular models, indicate that although hepcidin regulation by iron stores is maintained in CHC, the suppression of this hormone by hepatitis C virus is likely an important factor in liver iron accumulation in this condition.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	116-124
19882752-2	2009	Hepcidin is a principal regulator of iron homeostasis.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
23656728-5	2013	The hepcidin-ferritin ratio indicated hepcidin was relatively suppressed given the degree of iron loading.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	4-12
23656728-5	2013	The hepcidin-ferritin ratio indicated hepcidin was relatively suppressed given the degree of iron loading.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	38-46
23656728-10	2013	Hepcidin levels in patients with beta-thalassemia major dynamically reflect competing influences from erythropoiesis, anemia, and iron overload.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	0-8
23696640-0	2013	alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond.	Iron	118-122	alpha hemoglobin stabilizing protein	Homo sapiens	0-36
21136948-1	2009	Hepcidin, a key regulator of iron homeostasis, is known to have three isoforms: hepcidin-20, -22, and -25.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
21136948-1	2009	Hepcidin, a key regulator of iron homeostasis, is known to have three isoforms: hepcidin-20, -22, and -25.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	80-88
21136948-2	2009	Hepcidin-25 is thought to be the major isoform and the only one known to be involved in iron metabolism; the physiological roles of other isoforms are poorly understood.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	0-8
21136948-10	2009	We believe our method will facilitate quantitative investigation of the role hepcidin plays in iron homeostasis.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	77-85
23696640-0	2013	alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond.	Iron	118-122	alpha hemoglobin stabilizing protein	Homo sapiens	38-42
23696640-6	2013	Comparisons of iron-ligand geometry using extended x-ray absorption fine structure spectroscopy showed that AHSP binding induces a small 0.03 A lengthening of the Fe-O2 bond, explaining previous reports that AHSP decreases alphaHb O2 affinity roughly 4-fold and promotes autooxidation due primarily to a 3-4-fold increase in the rate of O2 dissociation.	Iron	15-19	alpha hemoglobin stabilizing protein	Homo sapiens	108-112
19764800-1	2009	The recombinant diheme cytochrome c(4) from the psycrophilic bacterium Pseudoalteromonas haloplanktis TAC 125 and its Met64Ala and Met164Ala variants, which feature a hydroxide ion axially bound to the heme iron at the N- and C-terminal domains, respectively, were found to exchange electrons efficiently with a gold electrode coated with a SAM of 11-mercapto-1-undecanoic acid.	Iron	207-211	hemE	Pseudoalteromonas haloplanktis TAC125	18-22
23696640-6	2013	Comparisons of iron-ligand geometry using extended x-ray absorption fine structure spectroscopy showed that AHSP binding induces a small 0.03 A lengthening of the Fe-O2 bond, explaining previous reports that AHSP decreases alphaHb O2 affinity roughly 4-fold and promotes autooxidation due primarily to a 3-4-fold increase in the rate of O2 dissociation.	Iron	163-165	alpha hemoglobin stabilizing protein	Homo sapiens	108-112
23696640-6	2013	Comparisons of iron-ligand geometry using extended x-ray absorption fine structure spectroscopy showed that AHSP binding induces a small 0.03 A lengthening of the Fe-O2 bond, explaining previous reports that AHSP decreases alphaHb O2 affinity roughly 4-fold and promotes autooxidation due primarily to a 3-4-fold increase in the rate of O2 dissociation.	Iron	163-165	alpha hemoglobin stabilizing protein	Homo sapiens	208-212
23843990-0	2013	Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins.	Iron	46-50	ceruloplasmin	Homo sapiens	0-13
19393287-1	2009	Hepcidin is a 25-residue hepatic peptide that regulates iron absorption from the diet and tissue iron distribution.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
19393287-1	2009	Hepcidin is a 25-residue hepatic peptide that regulates iron absorption from the diet and tissue iron distribution.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
19393287-3	2009	Increased hepcidin expression mediates iron retention in the anemias of inflammation and plays a pathogenic role in iron-refractory iron-deficiency anemia (IRIDA).	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	10-18
19393287-3	2009	Increased hepcidin expression mediates iron retention in the anemias of inflammation and plays a pathogenic role in iron-refractory iron-deficiency anemia (IRIDA).	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	10-18
19393287-4	2009	Because of its clinical importance, Hepcidin is expected to be a useful biomarker for diagnosis and management of iron-related disorders.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	36-44
23986220-4	2013	Hepcidin, discovered in the year 2000, is an endogenous peptide responsible for iron homeostasis.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
19900832-2	2009	Bmp6-/- null mice have low hepcidin serum levels and an iron overload, resembling hereditary hemochromatosis, which may cause a reduced number of pancreatic beta-cells, increased serum glucose and diabetes.	Iron	56-60	bone morphogenetic protein 6	Mus musculus	0-4
23986220-5	2013	Recent data suggests that hepcidin is a major mediator of anemia and plays a central role in iron homeostasis and metabolism.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	26-34
19592582-1	2009	Mutations leading to abrogation of matriptase-2 proteolytic activity in humans are associated with an iron-refractory iron deficiency anemia (IRIDA) due to elevated hepcidin levels.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	165-173
23241678-4	2013	RESULTS: Hepcidin concentration decreased gradually from the first to the second and third trimester to undetectable levels (&lt;= 0.5 nmol/L) which was paralleled by decreasing hemoglobin levels and changes in iron parameters indicative for iron deficiency.	Iron	211-215	hepcidin antimicrobial peptide	Homo sapiens	9-17
19636315-13	2009	In a multiple regression model, serum hepcidin was correlated with BMI-SDS (P=0.020) and body iron (P=0.029), but not with the inflammatory markers.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	38-46
19710232-0	2009	An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis.	Iron	85-89	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	28-32
19710232-4	2009	Additional atm3 alleles were identified among sirtinol-resistant lines, correlating with decreased activities of aldehyde oxidases, cytosolic enzymes that convert sirtinol into an auxin analog, and depend on iron-sulfur (Fe-S) and molybdenum cofactor (Moco) as prosthetic groups.	Iron	221-225	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	11-15
19710232-10	2009	Our data suggest that Arabidopsis ATM3 may transport (1) at least two distinct compounds or (2) a single compound required for both Fe-S and Moco assembly machineries in the cytosol, but not iron.	Iron	132-136	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	34-38
23241678-5	2013	During gestation hepcidin levels correlated with iron parameters, but not with inflammatory markers.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	17-25
19682329-1	2009	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1) but has distinct functions from TfR1 in iron homeostasis.	Iron	118-122	transferrin receptor 2	Homo sapiens	0-22
19682329-1	2009	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1) but has distinct functions from TfR1 in iron homeostasis.	Iron	118-122	transferrin receptor 2	Homo sapiens	24-28
23901530-1	2013	The promotional effect of nanosized Ru, Fe, Au, and Mn particles on VOHPO4 x 0.5H2O (VHP) catalytic properties was investigated in benzene hydroxylation reaction using hydrogen hydroperoxide (H2O2) as oxidant.	Iron	40-42	dual specificity phosphatase 28	Homo sapiens	85-88
19711962-1	2009	A density functional theory study for the bis- and monothiophene complexes of Fe, Co, and Ni (MT2 and MT, T = thiophene, M = Fe, Co, Ni) was performed to understand their coordination geometries, bonding properties, vibration spectra and singlet excited state spectra.	Iron	78-80	metallothionein 2A	Homo sapiens	94-97
23184650-0	2013	Akt/Nrf2 activated upregulation of heme oxygenase-1 involves in the role of Rg1 against ferrous iron-induced neurotoxicity in SK-N-SH cells.	Iron	96-100	heme oxygenase 1	Homo sapiens	35-51
19622835-2	2009	Iron normally induces expression of the BMP6 ligand, which, in turn, activates the BMP/Smad signaling cascade directing hepcidin expression.	Iron	0-4	bone morphogenetic protein 6	Mus musculus	40-44
19622835-2	2009	Iron normally induces expression of the BMP6 ligand, which, in turn, activates the BMP/Smad signaling cascade directing hepcidin expression.	Iron	0-4	SMAD family member 1	Mus musculus	87-91
23184650-0	2013	Akt/Nrf2 activated upregulation of heme oxygenase-1 involves in the role of Rg1 against ferrous iron-induced neurotoxicity in SK-N-SH cells.	Iron	96-100	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	76-79
23184650-2	2013	Our previous studies have observed that Rg1, a major pharmacologically active ingredient from Ginseng, could protect dopaminergic neurons by reducing nigral iron levels through regulating the expression of iron transporters in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mice.	Iron	157-161	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	40-43
23184650-3	2013	The aim of this study is to investigate other mechanism involved in the cytoprotection of Rg1 against iron-induced neurotoxicity in human neuroblastoma SK-N-SH cells.	Iron	102-106	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	90-93
19706893-3	2009	The divalent metal transporter 1 (DMT1) plays a central role in the regulation of Fe as well as other metals; hence, failure of DMT1 regulation is linked to human brain pathology.	Iron	82-84	solute carrier family 11 member 2	Homo sapiens	4-32
23184650-4	2013	Significant rescue of Rg1 on cell viability against 100 muM ferrous iron-induced neurotoxicity was observed.	Iron	60-72	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	22-25
19706893-3	2009	The divalent metal transporter 1 (DMT1) plays a central role in the regulation of Fe as well as other metals; hence, failure of DMT1 regulation is linked to human brain pathology.	Iron	82-84	solute carrier family 11 member 2	Homo sapiens	34-38
19706893-3	2009	The divalent metal transporter 1 (DMT1) plays a central role in the regulation of Fe as well as other metals; hence, failure of DMT1 regulation is linked to human brain pathology.	Iron	82-84	solute carrier family 11 member 2	Homo sapiens	128-132
23184650-8	2013	These results suggest that the neuroprotective effects of Rg1 against iron toxicity are attributed to the anti-oxidative properties by activating Akt/Nrf2 pathway and increasing Nrf2-induced expression of HO-1 and Cu/Zn SOD.	Iron	70-74	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	58-61
19706893-6	2009	Using human neurons we show the Ndfip1 is upregulated and binds to DMT1 in response to Fe and cobalt (Co) exposure.	Iron	87-89	Nedd4 family interacting protein 1	Homo sapiens	32-38
19706893-6	2009	Using human neurons we show the Ndfip1 is upregulated and binds to DMT1 in response to Fe and cobalt (Co) exposure.	Iron	87-89	solute carrier family 11 member 2	Homo sapiens	67-71
23807651-8	2013	Release of iron from the liver relies on ferroportin and the ferroxidase activity of ceruloplasmin which is found in blood in a soluble form.	Iron	11-15	ceruloplasmin	Homo sapiens	85-98
23670730-2	2013	The study of the catalytic activity and selectivity of iron(III), gold(I), and Bronsted triflimides has unveiled that iron(III) triflimide [Fe(NTf2)3] is a robust catalyst under heating conditions, whereas gold(I) triflimide, even stabilized by PPh3, readily decomposes at 80  C and releases triflimidic acid (HNTf2) that can catalyze the corresponding reaction, as shown by in situ (19)F, (15)N, and (31)P NMR spectroscopy.	Iron	55-59	protein phosphatase 4 catalytic subunit	Homo sapiens	245-249
19610021-0	2009	Mutation analysis of hepcidin and ferroportin genes in Italian prospective blood donors with iron overload.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	21-29
19610021-2	2009	Hepcidin, a recently identified antimicrobial peptide produced in the liver, has been shown to play a central role in the homeostatic regulation of iron absorption and distribution [1].	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	0-8
19622342-1	2009	The heme iron coordination of ferric myoglobin (Mb) in the presence of 9.0M urea and 8.0M acetic acid at acidic pH values has been probed by electronic absorption, magnetic circular dichroism and resonance Raman spectroscopic techniques.	Iron	9-13	myoglobin	Homo sapiens	37-46
19622342-1	2009	The heme iron coordination of ferric myoglobin (Mb) in the presence of 9.0M urea and 8.0M acetic acid at acidic pH values has been probed by electronic absorption, magnetic circular dichroism and resonance Raman spectroscopic techniques.	Iron	9-13	myoglobin	Homo sapiens	48-50
23454680-0	2013	Role of alpha-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity.	Iron	107-111	heme oxygenase 1	Homo sapiens	44-95
19423366-0	2009	Activation and inactivation of the iron hormone hepcidin: Biochemical characterization of prohepcidin cleavage and sequential degradation to N-terminally truncated hepcidin isoforms.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	48-56
23454680-2	2013	Iron is also believed to serve as a major contributor by inducing oxidative stress and alpha-syn aggregation.	Iron	0-4	synuclein alpha	Homo sapiens	87-96
19423366-1	2009	The hormone hepcidin is produced mainly in the liver in response to iron loading and inflammation and secreted into the circulation as a 25-amino acid peptide.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	12-20
23454680-3	2013	Here, we report that down-regulation of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) may contribute to iron-induced alpha-syn aggregation.	Iron	128-132	heme oxygenase 1	Homo sapiens	86-102
21305139-7	2009	Several recent lines of evidence, including the facts that the concentrations of circulating gastrins are increased in mice and humans with the iron overload disease haemochromatosis, and that transferrin saturation positively correlates with circulating gastrin concentrations, suggest that gastrins may be involved in iron homeostasis.	Iron	144-148	gastrin	Homo sapiens	93-100
23454680-3	2013	Here, we report that down-regulation of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) may contribute to iron-induced alpha-syn aggregation.	Iron	128-132	heme oxygenase 1	Homo sapiens	104-108
23454680-3	2013	Here, we report that down-regulation of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) may contribute to iron-induced alpha-syn aggregation.	Iron	128-132	synuclein alpha	Homo sapiens	141-150
19825683-0	2009	Post-translational regulation of AtFER2 ferritin in response to intracellular iron trafficking during fruit development in Arabidopsis.	Iron	78-82	ferritin 2	Arabidopsis thaliana	33-39
23596161-12	2013	Hepcidin was found to be a significant predictor of iron absorption (standardized beta = -0.63, P = 0.001, R(2) = 0.40) from the reference dose.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
19706422-2	2009	Recombinant human deoxyhypusine hydroxylase (hDOHH) has been reported to have oxygen- and iron-dependent activity, an estimated iron/holoprotein stoichiometry of 2, and a visible band at 630 nm responsible for the blue color of the as-isolated protein.	Iron	90-94	deoxyhypusine hydroxylase	Homo sapiens	18-43
19706422-2	2009	Recombinant human deoxyhypusine hydroxylase (hDOHH) has been reported to have oxygen- and iron-dependent activity, an estimated iron/holoprotein stoichiometry of 2, and a visible band at 630 nm responsible for the blue color of the as-isolated protein.	Iron	90-94	deoxyhypusine hydroxylase	Homo sapiens	45-50
23780697-3	2013	However, in the presence of iron, the HCN was captured in the form of a ferrocyanide, partially inhibiting the formation of amino acids.	Iron	28-32	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	38-41
19542226-3	2009	PTOX and AOX contain 20 highly conserved amino acids, six of which are Fe-binding ligands.	Iron	71-73	Alternative oxidase family protein	Arabidopsis thaliana	0-4
23464809-1	2013	HJV (haemojuvelin) plays a key role in iron metabolism in mammals by regulating expression of the liver-derived hormone hepcidin, which controls systemic iron uptake and release.	Iron	39-43	hemojuvelin BMP co-receptor	Homo sapiens	0-3
19672300-5	2009	Here, we report that hepcidin, a liver secreted hormone that shepherds iron homeostasis, exhibits a biphasic pattern of expression following UPR activation: its levels decreased in an early stage and increased with the maintenance of the stress response.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	21-29
23464809-1	2013	HJV (haemojuvelin) plays a key role in iron metabolism in mammals by regulating expression of the liver-derived hormone hepcidin, which controls systemic iron uptake and release.	Iron	39-43	hemojuvelin BMP co-receptor	Homo sapiens	5-17
19271990-6	2009	tBHP treatment also resulted in elevated transferrin receptors, followed by more iron acquisition in MtFt expressing cells.	Iron	81-85	ferritin mitochondrial	Homo sapiens	101-105
23464809-1	2013	HJV (haemojuvelin) plays a key role in iron metabolism in mammals by regulating expression of the liver-derived hormone hepcidin, which controls systemic iron uptake and release.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	120-128
19271990-8	2009	In conclusion, the current study indicates that both the newly acquired iron from the extracellular environment and internal iron redistribution from ferritin degradation may be responsible for the increased sensitivity to oxidative stress in MtFt-expressing cells.	Iron	72-76	ferritin mitochondrial	Homo sapiens	243-247
23464809-1	2013	HJV (haemojuvelin) plays a key role in iron metabolism in mammals by regulating expression of the liver-derived hormone hepcidin, which controls systemic iron uptake and release.	Iron	154-158	hemojuvelin BMP co-receptor	Homo sapiens	0-3
19271990-8	2009	In conclusion, the current study indicates that both the newly acquired iron from the extracellular environment and internal iron redistribution from ferritin degradation may be responsible for the increased sensitivity to oxidative stress in MtFt-expressing cells.	Iron	103-107	ferritin mitochondrial	Homo sapiens	243-247
23464809-1	2013	HJV (haemojuvelin) plays a key role in iron metabolism in mammals by regulating expression of the liver-derived hormone hepcidin, which controls systemic iron uptake and release.	Iron	154-158	hemojuvelin BMP co-receptor	Homo sapiens	5-17
23464809-1	2013	HJV (haemojuvelin) plays a key role in iron metabolism in mammals by regulating expression of the liver-derived hormone hepcidin, which controls systemic iron uptake and release.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	120-128
23464809-2	2013	Mutations in HJV cause juvenile haemochromatosis, a rapidly progressing iron overload disorder in humans.	Iron	72-76	hemojuvelin BMP co-receptor	Homo sapiens	13-16
19727608-3	2009	One of the key components of cellular stress response is heme oxygenase-1 (HO-1), the rate limiting enzyme in the process of degrading potentially toxic free heme into biliverdin, free iron and carbon monoxide.	Iron	185-189	heme oxygenase 1	Homo sapiens	57-73
23667491-5	2013	The present study was performed to characterize the expression profiles of the genes in ys1 and ys3 mutants to extend our understanding of Fe homeostasis in maize.	Iron	139-141	iron-phytosiderophore transporter yellow stripe 1	Zea mays	88-91
19727608-3	2009	One of the key components of cellular stress response is heme oxygenase-1 (HO-1), the rate limiting enzyme in the process of degrading potentially toxic free heme into biliverdin, free iron and carbon monoxide.	Iron	185-189	heme oxygenase 1	Homo sapiens	75-79
19545623-10	2009	We speculate that rhabdomyolysis-induced kidney damage involves direct interaction of myoglobin with mitochondria possibly resulting in iron ions release from myoglobin"s heme, which promotes the peroxidation of mitochondrial membranes.	Iron	136-140	myoglobin	Homo sapiens	86-95
19545623-10	2009	We speculate that rhabdomyolysis-induced kidney damage involves direct interaction of myoglobin with mitochondria possibly resulting in iron ions release from myoglobin"s heme, which promotes the peroxidation of mitochondrial membranes.	Iron	136-140	myoglobin	Homo sapiens	159-168
23667491-8	2013	In addition, these Fe deficiency-inducible genes were upregulated in both the ys1 and ys3 mutants, even under Fe-sufficient conditions.	Iron	19-21	iron-phytosiderophore transporter yellow stripe 1	Zea mays	78-81
23667491-8	2013	In addition, these Fe deficiency-inducible genes were upregulated in both the ys1 and ys3 mutants, even under Fe-sufficient conditions.	Iron	110-112	iron-phytosiderophore transporter yellow stripe 1	Zea mays	78-81
23667491-9	2013	Indeed, the Fe concentrations in the roots of ys1 and ys3 plants were lower than that of wild-type controls.	Iron	12-14	iron-phytosiderophore transporter yellow stripe 1	Zea mays	46-49
19541813-0	2009	HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	51-59
23667491-10	2013	These results suggest that ys1 and ys3 are Fe-deficient during growth in the presence of Fe.	Iron	43-45	iron-phytosiderophore transporter yellow stripe 1	Zea mays	27-30
19541813-1	2009	BACKGROUND AND OBJECTIVES: Increased serum hepcidin has been reported in patients receiving chronic hemodialysis, and hypothesized to contribute to the alterations of iron metabolism of end-stage renal disease.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	43-51
19541813-7	2009	In patients, hepcidin-25 correlated positively with ferritin and C reactive protein, and negatively with serum iron after adjustment for confounders.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	13-21
19541813-11	2009	CONCLUSIONS: Serum hepcidin-25 is increased in hemodialysis patients, regulated by iron stores and inflammation, and relatively reduced in subjects carrying frequent HFE mutations.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	19-27
19541813-12	2009	Hepcidin-25 may contribute to the pathogenesis of anemia by decreasing iron availability.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
23667491-10	2013	These results suggest that ys1 and ys3 are Fe-deficient during growth in the presence of Fe.	Iron	89-91	iron-phytosiderophore transporter yellow stripe 1	Zea mays	27-30
19556376-3	2009	Hepcidin, a small peptide produced by the liver, is a recently discovered key regulator of iron homeostasis.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
19556376-4	2009	Via regulation of ferroportin, hepcidin inhibits intestinal iron absorption and iron release from macrophages and hepatocytes.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	31-39
23187302-8	2013	RESULTS: Western blot analysis showed that the ratios of LC3-II to LC3-I and ATG5 levels were significantly upregulated at 6 hours and 1 day after ferrous iron injection.	Iron	147-159	autophagy related 5	Rattus norvegicus	77-81
19556376-4	2009	Via regulation of ferroportin, hepcidin inhibits intestinal iron absorption and iron release from macrophages and hepatocytes.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	31-39
19556376-5	2009	Because of its renal elimination and regulation by inflammation, it is possible that progressive renal insufficiency leads to altered hepcidin metabolism, subsequently affecting enteric absorption of iron and the availability of iron stores.	Iron	200-204	hepcidin antimicrobial peptide	Homo sapiens	134-142
19556376-5	2009	Because of its renal elimination and regulation by inflammation, it is possible that progressive renal insufficiency leads to altered hepcidin metabolism, subsequently affecting enteric absorption of iron and the availability of iron stores.	Iron	229-233	hepcidin antimicrobial peptide	Homo sapiens	134-142
23553477-10	2013	Analysis of the effect of mutated NUBPL on the assembly of the peripheral arm of complex I indicated that NUBPL is involved in assembly of iron-sulfur clusters early in the complex I assembly pathway.	Iron	139-143	NUBP iron-sulfur cluster assembly factor, mitochondrial	Homo sapiens	106-111
21314673-5	2009	The iron exporter ferroportin is downregulated within 1-6 h, followed by downregulation of transferrin receptor-1 (TfR1) and ferritin heavy chain (H-ferritin) mainly after 24-48 h. The hemochromatosis protein-1, a ligand of TfR1, peaked after 24 h. All effects were independent of iron supply with the exception of H-ferritin, which was restored by excess iron.	Iron	4-8	ferritin heavy chain 1	Homo sapiens	125-145
19621376-0	2009	CE-MS method development for peptides analysis, especially hepcidin, an iron metabolism marker.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	59-67
23390933-1	2013	Hepcidin is the major regulatory peptide hormone of iron metabolism, encoded by the HAMP (hepcidin antimicrobial peptide) gene.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
19621376-1	2009	A method for the resolution of a peptides mixture including hepcidin-25, an iron metabolism marker, was developed by CE-ESI-MS. Several strategies were tested to optimize peptide separation, such as the addition of cyclodextrins or organic solvents in the BGE or the use of coated capillaries.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	60-68
23390933-1	2013	Hepcidin is the major regulatory peptide hormone of iron metabolism, encoded by the HAMP (hepcidin antimicrobial peptide) gene.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	84-88
23390933-1	2013	Hepcidin is the major regulatory peptide hormone of iron metabolism, encoded by the HAMP (hepcidin antimicrobial peptide) gene.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	90-120
19549758-1	2009	Hepcidin is thought to control iron metabolism by interacting with the iron efflux transporter ferroportin.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
23694786-1	2013	BACKGROUND: Hepcidin is a central regulator of iron metabolism.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	12-20
19549758-8	2009	However, iron efflux from Caco-2 cells was significantly inhibited in the presence of hepcidin, suggesting that the peptide could block ferroportin function in these cells.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	86-94
19549758-9	2009	We conclude that hepcidin regulates the release of iron from both enterocytes and macrophages.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	17-25
23694786-9	2013	CONCLUSION: Our results indicate that hepcidin expression is regulated by iron and inflammatory factors in hepatitis B infection patients, and that the virus load can affect hepcidin production.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	38-46
18619522-8	2009	Heme oxygenase 1 (HO1) is an important component of the system for mobilization of iron from macrophages.	Iron	83-87	heme oxygenase 1	Homo sapiens	0-16
18619522-8	2009	Heme oxygenase 1 (HO1) is an important component of the system for mobilization of iron from macrophages.	Iron	83-87	heme oxygenase 1	Homo sapiens	18-21
18619522-10	2009	Increased cardiovascular disease associated with inflammation may be in part caused by elevated hepcidin levels that promote retention of iron within plaque macrophages.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	96-104
23313843-0	2013	Stability and iron oxidation properties of a novel homopolymeric plant ferritin from adzuki bean seeds: a comparative analysis with recombinant soybean seed H-1 chain ferritin.	Iron	14-18	ferritin-1, chloroplastic	Glycine max	71-79
18786614-4	2009	Acute-phase proteins, such as hepcidin, as well as pro- and anti-inflammatory cytokines affect iron acquisition and release pathways of monocytes and macrophages thereby leading to iron restriction within the RES and systemic hypoferremia.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	30-38
18786614-4	2009	Acute-phase proteins, such as hepcidin, as well as pro- and anti-inflammatory cytokines affect iron acquisition and release pathways of monocytes and macrophages thereby leading to iron restriction within the RES and systemic hypoferremia.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	30-38
23313843-6	2013	RESULTS: At high iron loading of protein, the extension peptide (EP) of plant ferritin was involved in iron oxidation, and the EP of ASF exhibited a much stronger iron oxidative activity than that of rH-1.	Iron	103-107	ferritin-1, chloroplastic	Glycine max	78-86
18786614-6	2009	In addition, inflammatory processes affect macrophage iron acquisition via erythrophagocytosis while hepcidin inhibits macrophage iron release via direct interaction with the central iron export protein ferroportin.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	101-109
18786614-6	2009	In addition, inflammatory processes affect macrophage iron acquisition via erythrophagocytosis while hepcidin inhibits macrophage iron release via direct interaction with the central iron export protein ferroportin.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	101-109
23313843-6	2013	RESULTS: At high iron loading of protein, the extension peptide (EP) of plant ferritin was involved in iron oxidation, and the EP of ASF exhibited a much stronger iron oxidative activity than that of rH-1.	Iron	103-107	ferritin-1, chloroplastic	Glycine max	78-86
23090785-1	2013	Heme oxygenase-1 (HO-1) is both beneficial and detrimental to the host in some viral infections by catalyzing the conversion of heme to biliverdin, iron, and carbon monoxide.	Iron	148-152	heme oxygenase 1	Homo sapiens	18-22
18337195-0	2009	Ferroportin-1 in the recurrence of hepatic iron overload after liver transplantation.	Iron	43-47	solute carrier family 40 member 1	Homo sapiens	0-13
18337195-2	2009	Here, we document the early recurrence of hepatic iron overload starting from host Kupffer cells and later involving hepatocytes in an Italian male submitted to liver transplantation for HCV-related cirrhosis, whose hemosiderosis was interpreted as related to a primary defect of iron handling by monocytic cells due to decreased Ferroportin-1 expression.	Iron	50-54	solute carrier family 40 member 1	Homo sapiens	330-343
19362144-3	2009	HO-1 serves a vital metabolic function as the rate-limiting step in the heme degradation pathway and in the maintenance of iron homeostasis.	Iron	123-127	heme oxygenase 1	Homo sapiens	0-4
23438060-1	2013	OBJECTIVES: Hepcidin, a peptide hormone released by hepatocytes into circulation is the main regulator of dietary iron absorption and cellular iron release.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	12-20
19362144-5	2009	The cytoprotective functions of HO-1 may be attributed to heme turnover, as well as to beneficial properties of its enzymatic reaction products: biliverdin-IXalpha, iron, and carbon monoxide (CO).	Iron	165-169	heme oxygenase 1	Homo sapiens	32-36
19554550-0	2009	Things that go BMP in the liver: bone morphogenetic protein 6 and the control of body iron homeostasis.	Iron	86-90	bone morphogenetic protein 1	Homo sapiens	15-18
23438060-1	2013	OBJECTIVES: Hepcidin, a peptide hormone released by hepatocytes into circulation is the main regulator of dietary iron absorption and cellular iron release.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	12-20
23438060-10	2013	In iron deficiency anemia patients on oral iron supplementation and in beta-thalassemia subjects, hepcidin levels were similar to those found in healthy subjects.	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	98-106
23413836-1	2013	Hepcidin is a liver-secreted small disulfide-rich peptide that plays a key role in iron homeostasis by binding and mediating the internalization and degradation of the only iron efflux transporter so far known, ferroportin (Fpn).	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	0-8
19558223-5	2009	Increased expression of ferritin and elevated levels of RNA for DMT1, proteins for iron storage and transport respectively, followed MNP exposures, but values were significant for only those with co-exposures to inorganic acid and organic aerosols.	Iron	83-87	doublesex and mab-3 related transcription factor 1	Homo sapiens	64-68
23413836-1	2013	Hepcidin is a liver-secreted small disulfide-rich peptide that plays a key role in iron homeostasis by binding and mediating the internalization and degradation of the only iron efflux transporter so far known, ferroportin (Fpn).	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	0-8
23350672-8	2013	Hemopexin sequesters heme, thus preventing unregulated heme uptake that leads to toxicity; it safely delivers heme to neuronal cells; and it activates the induction of proteins including HO1 and hAPP that keep heme and iron at safe levels in neurons.	Iron	219-223	heme oxygenase 1	Homo sapiens	187-190
19039664-2	2009	Heme uptake via endocytosis of heme-HPX followed by heme catabolism by heme oxygenase-1 (HMOX1) raises regulatory iron pools, thus linking heme metabolism with that of iron.	Iron	114-118	heme oxygenase 1	Homo sapiens	71-87
19039664-2	2009	Heme uptake via endocytosis of heme-HPX followed by heme catabolism by heme oxygenase-1 (HMOX1) raises regulatory iron pools, thus linking heme metabolism with that of iron.	Iron	114-118	heme oxygenase 1	Homo sapiens	89-94
23446829-6	2013	Our data demonstrated that Hx prevented heme-iron loading in the cardiovascular system, thus limiting the production of reactive oxygen species, the induction of adhesion molecules, and the oxidative inactivation of nitric oxide synthase/nitric oxide, and promoted heme recovery and detoxification by the liver mainly through the induction of heme oxygenase activity.	Iron	45-49	hemopexin	Mus musculus	27-29
19039664-2	2009	Heme uptake via endocytosis of heme-HPX followed by heme catabolism by heme oxygenase-1 (HMOX1) raises regulatory iron pools, thus linking heme metabolism with that of iron.	Iron	168-172	heme oxygenase 1	Homo sapiens	71-87
19039664-2	2009	Heme uptake via endocytosis of heme-HPX followed by heme catabolism by heme oxygenase-1 (HMOX1) raises regulatory iron pools, thus linking heme metabolism with that of iron.	Iron	168-172	heme oxygenase 1	Homo sapiens	89-94
23517143-2	2013	In our previous study, the promoter of alcohol dehydrogenase, iron containing, 1 (ADHFE1) was most highly methylated in CRC compared to normal colorectal mucosa.	Iron	62-66	alcohol dehydrogenase, iron containing, 1	Mus musculus	82-88
19344417-0	2009	Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	24-32
19344417-7	2009	We concluded that even mild increases in serum hepcidin and IL-6 concentrations result in a disturbed host iron homeostasis.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	47-55
19344417-8	2009	Serum hepcidin, Ret-H(e) and Delta-H(e) (Ret-H(e) minus RBC-H(e)) are promising biomarkers to select those individuals who will benefit from iron supplements in malaria endemic regions, while the sTfR/log ferritin ratio should be used with caution to assess iron status during malaria.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	6-14
19344417-8	2009	Serum hepcidin, Ret-H(e) and Delta-H(e) (Ret-H(e) minus RBC-H(e)) are promising biomarkers to select those individuals who will benefit from iron supplements in malaria endemic regions, while the sTfR/log ferritin ratio should be used with caution to assess iron status during malaria.	Iron	141-145	ret proto-oncogene	Homo sapiens	16-19
19344417-8	2009	Serum hepcidin, Ret-H(e) and Delta-H(e) (Ret-H(e) minus RBC-H(e)) are promising biomarkers to select those individuals who will benefit from iron supplements in malaria endemic regions, while the sTfR/log ferritin ratio should be used with caution to assess iron status during malaria.	Iron	141-145	ret proto-oncogene	Homo sapiens	41-44
23427827-6	2013	Fitting of the data with the Poole-Frenkel model indicates a correlation between the barrier height for electron transfer and the ease of CYP2C9-mediated metabolism of the bound substrates, though the spin state of iron is not well correlated.	Iron	215-219	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	138-144
19344417-8	2009	Serum hepcidin, Ret-H(e) and Delta-H(e) (Ret-H(e) minus RBC-H(e)) are promising biomarkers to select those individuals who will benefit from iron supplements in malaria endemic regions, while the sTfR/log ferritin ratio should be used with caution to assess iron status during malaria.	Iron	258-262	ret proto-oncogene	Homo sapiens	41-44
23315725-1	2013	Lactoferrin is an iron-binding glycoprotein found in the milk of most mammals for which various biological functions have been reported, such as antimicrobial activity and bifidogenic activity.	Iron	18-22	lactotransferrin	Bos taurus	0-11
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	62-66	hemojuvelin BMP co-receptor	Homo sapiens	13-24
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	62-66	hemojuvelin BMP co-receptor	Homo sapiens	26-29
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	160-168
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	62-66	hemojuvelin BMP co-receptor	Homo sapiens	173-176
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	0-8
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	119-123	hemojuvelin BMP co-receptor	Homo sapiens	13-24
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	119-123	hemojuvelin BMP co-receptor	Homo sapiens	26-29
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	160-168
19306018-1	2009	Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes.	Iron	119-123	hemojuvelin BMP co-receptor	Homo sapiens	173-176
23589789-1	2013	This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic role of hepcidin in different types of anemia.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	43-51
19454498-1	2009	BACKGROUND: Hepcidin is an iron regulatory peptide produced by the liver in response to inflammation and elevated systemic iron.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	12-20
19454498-1	2009	BACKGROUND: Hepcidin is an iron regulatory peptide produced by the liver in response to inflammation and elevated systemic iron.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	12-20
23589789-3	2013	Considering the central role of hepcidin in iron arrangement, it is reasonable to ponder its therapeutic use mainly in cases of iron overload.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	32-40
23589789-3	2013	Considering the central role of hepcidin in iron arrangement, it is reasonable to ponder its therapeutic use mainly in cases of iron overload.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	32-40
23065507-2	2013	Hepcidin, an important regulator of iron homeostasis, is suggested to be causally related to anemia of inflammation.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
19416869-7	2009	Thus, when dystrophin or utrophin binds, actin becomes less like cast iron (strong but brittle) and more like steel (stronger and more resilient).	Iron	70-74	dystrophin	Homo sapiens	11-21
23065507-9	2013	We found strong correlations between plasma hepcidin and body iron status, C-reactive protein and erythropoietin levels.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	44-52
23300182-7	2013	These observations suggest that patients with SF3B1 mutation have inappropriately low hepcidin levels, which may explain their propensity to parenchymal iron loading.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	86-94
19035761-5	2009	In one case, a neutral bis(chelate)iron compound was prepared by reduction of the corresponding iron dication, [(PDI)2Fe]2+, providing chemical confirmation of electrochemically generated species that were previously reported as too reducing to isolate.	Iron	35-39	peptidyl arginine deiminase 1	Homo sapiens	113-116
19035761-8	2009	Thus, the two-electron reduction of the diamagnetic, low-spin complex [(PDI)2Fe]2+ to [(PDI)2Fe] is ligand-based with a concomitant spin change at iron.	Iron	147-151	peptidyl arginine deiminase 1	Homo sapiens	72-75
19035761-8	2009	Thus, the two-electron reduction of the diamagnetic, low-spin complex [(PDI)2Fe]2+ to [(PDI)2Fe] is ligand-based with a concomitant spin change at iron.	Iron	147-151	peptidyl arginine deiminase 1	Homo sapiens	88-91
23039064-4	2013	RESULTS: We found that hepcidin is not correlated with its precursor, but it is strongly positively correlated with the total iron concentration.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	23-31
19407375-3	2009	To analyze the structural properties of TTHA1623, the crystal structures of its iron-bound and zinc-bound forms have been determined to 2.8 and 2.2 A resolution, respectively.	Iron	80-84	MBL fold metallo-hydrolase	Thermus thermophilus HB8	40-48
23303869-6	2013	This effect was shown to be iron-dependent, because iron repletion at postnatal d 21 normalized mTOR activity in the reversible DN TfR-1 model (62% reduction compared with unrepleted mice; P &lt; 0.05).	Iron	28-32	mechanistic target of rapamycin kinase	Mus musculus	96-100
19285482-0	2009	The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane.	Iron	61-65	Fe(2+) transporter	Saccharomyces cerevisiae S288C	47-52
23303869-6	2013	This effect was shown to be iron-dependent, because iron repletion at postnatal d 21 normalized mTOR activity in the reversible DN TfR-1 model (62% reduction compared with unrepleted mice; P &lt; 0.05).	Iron	52-56	mechanistic target of rapamycin kinase	Mus musculus	96-100
23303869-7	2013	In the permanent DMT-1 CKO model, suppression of ID-induced mTOR hyperactivity by rapamycin administered during the sensitive period for iron improved Morris water maze performance despite ongoing ID (DMT-1 wild-type and DMT-1 CKO mice reached criterion in 3 d compared with 4 d necessary for vehicle-treated DMT-1 CKO mice; P &lt; 0.05).	Iron	137-141	mechanistic target of rapamycin kinase	Mus musculus	60-64
19212416-1	2009	Hepcidin is a critical inhibitor of iron export from macrophages, enterocytes, and hepatocytes.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
23512854-4	2013	Knocking out both YSL4 and YSL6 greatly reduces the plant"s ability to cope with excess iron.	Iron	88-92	YELLOW STRIPE like 6	Arabidopsis thaliana	27-31
23512854-6	2013	Elemental analysis and histochemical staining indicate that iron is trapped in the chloroplasts of the ysl4 ysl6 double mutants, which also accumulate ferritins.	Iron	60-64	YELLOW STRIPE like 6	Arabidopsis thaliana	108-112
23512854-8	2013	Furthermore, ubiquitous expression of YSL4 or YSL6 dramatically reduces plant tolerance to iron deficiency and decreases chloroplastic iron content.	Iron	91-95	YELLOW STRIPE like 6	Arabidopsis thaliana	46-50
19367309-0	2009	Is hepcidin the star player in iron metabolism in chronic kidney disease?	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	3-11
19367309-2	2009	Hepcidin is a circulating peptide produced in the liver that regulates efflux of iron from the cells.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
23512854-9	2013	These data demonstrate a fundamental role for YSL4 and YSL6 in managing chloroplastic iron.	Iron	86-90	YELLOW STRIPE like 6	Arabidopsis thaliana	55-59
23512854-10	2013	YSL4 and YSL6 expression patterns support their physiological role in detoxifying iron during plastid dedifferentiation occurring in embryogenesis and senescence.	Iron	82-86	YELLOW STRIPE like 6	Arabidopsis thaliana	9-13
19261733-3	2009	One of them, SUCCINATE DEHYDROGENASE2-3 (SDH2-3), is specifically expressed in the embryo during seed maturation, suggesting that SDH2-3 may have a role as the complex II iron-sulfur subunit during embryo maturation and/or germination.	Iron	171-175	succinate dehydrogenase 2-3	Arabidopsis thaliana	13-39
23382199-2	2013	Unlike the utilization of H(2)O(2) or O(2) as a mediator of catalysis by other heme-containing enzymes (e.g., P450), OxdA is notable for the direct binding of a substrate to the heme iron.	Iron	183-187	D-amino acid oxidase	Homo sapiens	117-121
19261733-3	2009	One of them, SUCCINATE DEHYDROGENASE2-3 (SDH2-3), is specifically expressed in the embryo during seed maturation, suggesting that SDH2-3 may have a role as the complex II iron-sulfur subunit during embryo maturation and/or germination.	Iron	171-175	succinate dehydrogenase 2-3	Arabidopsis thaliana	41-47
19261733-3	2009	One of them, SUCCINATE DEHYDROGENASE2-3 (SDH2-3), is specifically expressed in the embryo during seed maturation, suggesting that SDH2-3 may have a role as the complex II iron-sulfur subunit during embryo maturation and/or germination.	Iron	171-175	succinate dehydrogenase 2-3	Arabidopsis thaliana	130-136
19269833-5	2009	Computational docking to a model of AtNCED3 supports a mechanism of inhibition through coordination of the heteroatom with the non-heme iron in the enzyme active site.	Iron	136-140	nine-cis-epoxycarotenoid dioxygenase 3	Arabidopsis thaliana	36-43
23382199-4	2013	We then constructed OxdA mutants in which each of the polar amino acids lying within ~6 A of the iron atom of the heme was converted to alanine.	Iron	97-101	D-amino acid oxidase	Homo sapiens	20-24
22835525-1	2013	The human hepcidin-25 hormone has a key role in iron regulation in blood.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	10-18
19136476-0	2009	15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS.	Iron	176-180	heme oxygenase 1	Homo sapiens	67-127
23291405-1	2013	Fe(VI) was evaluated to treat metal-sulfides such as Fe-S, Pb-S, Cu-S and Cd-S contained in mine tailings known to generate acidic mine drainages.	Iron	0-2	CDP-diacylglycerol synthase 1	Homo sapiens	74-78
19156547-2	2009	Because iron incorporated into cells by the transferrin receptor is essential for cell/nuclear function, we determined whether fetal oocyte expression of transferrin receptor and the nuclear protein Ki67 were developmentally regulated by estrogen and associated with DNA integrity/fragmentation.	Iron	8-12	transferrin receptor protein 1	Papio anubis	44-64
19252488-0	2009	Lack of the bone morphogenetic protein BMP6 induces massive iron overload.	Iron	60-64	bone morphogenetic protein 6	Mus musculus	39-43
23291405-4	2013	The order of initial rates for the Fe(VI) reduction was Pb-S &gt; Cu-S &gt; Fe-S &gt; Cd-S.	Iron	76-80	CDP-diacylglycerol synthase 1	Homo sapiens	86-90
19252488-4	2009	We show here that targeted disruption of Bmp6 in mice causes a rapid and massive accumulation of iron in the liver, the acinar cells of the exocrine pancreas, the heart and the renal convoluted tubules.	Iron	97-101	bone morphogenetic protein 6	Mus musculus	41-45
23196129-2	2013	Here, high CP expression was noted for the organic anion transporters, Oat1 (SLC22A6 or NKT) and Oat3 (SLC22A8) which are also the principal Oats in the renal proximal tubule, as well as SLC22A17, hypothesized to be involved in iron transport.	Iron	228-232	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	97-101
19252488-7	2009	This indicates that Bmp6 is critical for iron homeostasis and that it is functionally nonredundant with other members of the Bmp subfamily.	Iron	41-45	bone morphogenetic protein 6	Mus musculus	20-24
19252488-9	2009	The iron burden in Bmp6 mutant mice is significantly greater than that in mice deficient in the gene associated with classical hemochromatosis (Hfe), suggesting that mutations in BMP6 might cause iron overload in humans with severe juvenile hemochromatosis for which the genetic basis has not yet been characterized.	Iron	4-8	bone morphogenetic protein 6	Mus musculus	19-23
19252488-9	2009	The iron burden in Bmp6 mutant mice is significantly greater than that in mice deficient in the gene associated with classical hemochromatosis (Hfe), suggesting that mutations in BMP6 might cause iron overload in humans with severe juvenile hemochromatosis for which the genetic basis has not yet been characterized.	Iron	4-8	bone morphogenetic protein 6	Mus musculus	179-183
19252488-9	2009	The iron burden in Bmp6 mutant mice is significantly greater than that in mice deficient in the gene associated with classical hemochromatosis (Hfe), suggesting that mutations in BMP6 might cause iron overload in humans with severe juvenile hemochromatosis for which the genetic basis has not yet been characterized.	Iron	196-200	bone morphogenetic protein 6	Mus musculus	179-183
23196129-2	2013	Here, high CP expression was noted for the organic anion transporters, Oat1 (SLC22A6 or NKT) and Oat3 (SLC22A8) which are also the principal Oats in the renal proximal tubule, as well as SLC22A17, hypothesized to be involved in iron transport.	Iron	228-232	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	103-110
23165433-6	2013	The UV-visible spectra of FeCl(3), H(4)L and their mixture in DMF solution indicate that the iron complex is the absorbing species and the presence of the free ligand in the irradiated solution suggests that the ligand is potentially acting as a catalyst to the photoreduction of Fe(III) to Fe(II), while electrochemistry points to a mixed-valent (Fe(II)-Fe(III)) intermediate in the process.	Iron	93-97	H4 clustered histone 7	Homo sapiens	35-40
19240917-1	2009	1,6-Dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ716) and 4-hydroxy-2-methyl-3-pyridinecarboxylic acid (DQ2) were evaluated for possible application to iron (Fe) and aluminium (Al) chelation therapy.	Iron	155-159	torsin family 1 member A	Homo sapiens	107-110
19240917-1	2009	1,6-Dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ716) and 4-hydroxy-2-methyl-3-pyridinecarboxylic acid (DQ2) were evaluated for possible application to iron (Fe) and aluminium (Al) chelation therapy.	Iron	161-163	torsin family 1 member A	Homo sapiens	107-110
19291818-7	2009	Hepcidin is an iron-regulatory hormone synthesized by the liver, which plays a pivotal role in iron homeostasis.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
19291818-16	2009	Due to its crucial role in the regulation of body iron stores, hepcidin may act as a secondary risk factor in the progression of alcoholic liver disease.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	63-71
23395172-3	2013	Here, we show that the mammalian homolog of HRG1, a transmembrane heme permease in C. elegans, is essential for macrophage iron homeostasis and transports heme from the phagolysosome to the cytoplasm during EP.	Iron	123-127	solute carrier family 48 member 1	Homo sapiens	44-48
19116239-1	2009	BACKGROUND: Liver synthesizes hepcidin in response to iron overload, leading to down-regulation of duodenal iron absorption.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	30-38
19116239-1	2009	BACKGROUND: Liver synthesizes hepcidin in response to iron overload, leading to down-regulation of duodenal iron absorption.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	30-38
23395172-7	2013	Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism.	Iron	69-73	solute carrier family 48 member 1	Homo sapiens	19-23
19176722-7	2009	Our data also support a role for ICS1 (SA) in iron and calcium homeostasis and identify components of SA cross talk with other phytohormones.	Iron	46-50	ADC synthase superfamily protein	Arabidopsis thaliana	33-37
23395172-7	2013	Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism.	Iron	69-73	solute carrier family 48 member 1	Homo sapiens	138-142
23395172-7	2013	Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism.	Iron	171-175	solute carrier family 48 member 1	Homo sapiens	19-23
19283067-7	2009	Increased binding of Tf to the cerebellar Purkinje cell neurons of sCJD brains further indicates upregulation of TfR and a phenotype of neuronal iron deficiency in diseased brains despite increased iron levels.	Iron	145-149	coagulation factor III, tissue factor	Homo sapiens	21-23
23395172-7	2013	Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism.	Iron	171-175	solute carrier family 48 member 1	Homo sapiens	138-142
23395173-1	2013	Iron regulatory proteins (Irps) 1 and 2 posttranscriptionally control the expression of transcripts that contain iron-responsive element (IRE) sequences, including ferritin, ferroportin, transferrin receptor, and hypoxia-inducible factor 2alpha (HIF2alpha).	Iron	113-117	endothelial PAS domain protein 1	Mus musculus	213-244
23395173-1	2013	Iron regulatory proteins (Irps) 1 and 2 posttranscriptionally control the expression of transcripts that contain iron-responsive element (IRE) sequences, including ferritin, ferroportin, transferrin receptor, and hypoxia-inducible factor 2alpha (HIF2alpha).	Iron	113-117	endothelial PAS domain protein 1	Mus musculus	246-255
23395174-0	2013	The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	Iron	37-41	endothelial PAS domain protein 1	Mus musculus	9-19
23395174-0	2013	The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	Iron	85-89	endothelial PAS domain protein 1	Mus musculus	9-19
23174565-2	2013	Iron deprivation also alters copper homeostasis, reflected by copper accumulation in the intestinal epithelium and induction of an intracellular copper-binding protein [metallothionein (Mt)] and a copper exporter [Menkes copper ATPase (Atp7a)].	Iron	0-4	ATPase copper transporting alpha	Rattus norvegicus	236-241
23174565-4	2013	It was, however, previously noted that Atp7a protein expression was induced more strongly than mRNA in the duodenum of iron-deprived rats, suggesting additional regulatory mechanisms.	Iron	119-123	ATPase copper transporting alpha	Rattus norvegicus	39-44
23174565-8	2013	Iron chelation with copper loading increased Atp7a mRNA and protein levels; however, contrary to our expectation, copper alone increased only protein levels.	Iron	0-4	ATPase copper transporting alpha	Rattus norvegicus	45-50
23264646-2	2013	Erv1 is also required for Fe-S cluster assembly in the cytosol, which uses at least one mitochondrially derived precursor.	Iron	26-30	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	0-4
23000435-3	2013	TERT mutations have very recently been associated with a spectrum of familial hepatic liver diseases often characterized by steatosis and hepatic iron overload, and have been reported to represent a frequent risk factor for cirrhosis, being observed in as much as 3-8% of unselected patients with different liver diseases.	Iron	146-150	telomerase reverse transcriptase	Homo sapiens	0-4
22274938-1	2013	This study was aimed at to check the influence of human lactoferrin (hLF) expression on iron homeostasis, flavonoids, and antioxidants in transgenic tobacco.	Iron	88-92	HLF transcription factor, PAR bZIP family member	Homo sapiens	69-72
22960056-0	2013	Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.	Iron	66-70	SMAD family member 6	Mus musculus	0-5
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	45-49	SMAD family member 6	Mus musculus	158-163
23078160-5	2013	Hepcidin, the peptide hormone that regulates systemic iron metabolism, decreases in response to erythropoiesis by facilitating increased iron efflux from ferroportin into circulation.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
23078160-5	2013	Hepcidin, the peptide hormone that regulates systemic iron metabolism, decreases in response to erythropoiesis by facilitating increased iron efflux from ferroportin into circulation.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	0-8
23078160-6	2013	However, during exercise, there is an alarming increase in the expression of hepcidin resulting in a negative iron balance in athletes.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	77-85
23164231-0	2013	Effect of iron saturation level of lactoferrin on osteogenic activity in vitro and in vivo.	Iron	10-14	lactotransferrin	Mus musculus	35-46
23164231-1	2013	We studied the effect of iron saturation level on the osteogenic activity of lactoferrin (LF) in vitro and in vivo.	Iron	25-29	lactotransferrin	Mus musculus	77-88
23164231-2	2013	Different iron saturation levels of LF (1.0, 9.0, 38, 58, and 96%) were prepared as the following samples: apo-LF, LF-9, LF-38, LF-58, and holo-LF.	Iron	10-14	lactotransferrin	Mus musculus	36-38
23164231-3	2013	Using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, we observed that the stimulating osteoblast proliferation activity of LF in vitro decreased with increasing iron saturation level at 100 and 1,000 mug/mL.	Iron	192-196	lactotransferrin	Mus musculus	154-156
22429447-2	2013	Down-regulation of hepcidin, a peptide which regulates systemic iron homeostasis, has been demonstrated in different conditions associated with PCT, such as haemochromatosis, chronic hepatitis C (CHC) and excessive alcohol intake.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	19-27
22429447-9	2013	CONCLUSION: Serum hepcidin levels are increased in patients with PCT suggesting that the mechanisms regulating iron homeostasis in PCT differ from those involved in other related disorders, such as haemochromatosis, HCV infection or alcohol abuse.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	18-26
22847740-5	2013	After 1 week of dietary loading with carbonyl iron, mice exhibited significant increases in serum iron and transferrin saturation, as well as in hepatic iron, Smad1/5/8 phosphorylation and bone morphogenetic protein 6 (BMP6), and hepcidin mRNAs.	Iron	46-50	SMAD family member 1	Mus musculus	159-166
22847740-5	2013	After 1 week of dietary loading with carbonyl iron, mice exhibited significant increases in serum iron and transferrin saturation, as well as in hepatic iron, Smad1/5/8 phosphorylation and bone morphogenetic protein 6 (BMP6), and hepcidin mRNAs.	Iron	46-50	bone morphogenetic protein 6	Mus musculus	189-217
22847740-5	2013	After 1 week of dietary loading with carbonyl iron, mice exhibited significant increases in serum iron and transferrin saturation, as well as in hepatic iron, Smad1/5/8 phosphorylation and bone morphogenetic protein 6 (BMP6), and hepcidin mRNAs.	Iron	46-50	bone morphogenetic protein 6	Mus musculus	219-223
22847740-7	2013	One day following parenteral administration of iron dextran, mice manifested elevated serum and hepatic iron levels and Smad1/5/8 phosphorylation, but no increases in transferrin saturation or BMP6 mRNA.	Iron	47-51	SMAD family member 1	Mus musculus	120-127
24067725-6	2013	p,p"-DDT enhanced microcytosis of reticulocytes, as well as mature erythrocytes, which occurred due to severe hypoferremia resulting from anemia of inflammation; however, plasma iron levels were attenuated probably through the inhibition of interleukin-6.	Iron	178-182	D-dopachrome tautomerase	Rattus norvegicus	5-8
24067725-7	2013	Our data suggests that long-term treatment with p,p"-DDT induces microcytic anemia, possibly because of the impairment of iron utility in erythrocytes.	Iron	122-126	D-dopachrome tautomerase	Rattus norvegicus	53-56
22854109-3	2013	Decreased expression of hepcidin, a hepatic hormone that suppresses dietary iron absorption in the duodenum, is frequently observed in NAFLD patients and has been postulated to be a cause of HIO.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	24-32
23749035-4	2013	For example, in the Ross Sea, burial of iron incorporated into biogenic silica is conservatively estimated as 11 mumol m-2 per year, which is in the same range as the major bioavailable iron inputs to this region.	Iron	40-44	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
23749035-4	2013	For example, in the Ross Sea, burial of iron incorporated into biogenic silica is conservatively estimated as 11 mumol m-2 per year, which is in the same range as the major bioavailable iron inputs to this region.	Iron	186-190	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
23533643-5	2013	We show that HLH-29 regulates ftn-1 expression via promoter sequences upstream of the iron-dependent element that is recognized by the hypoxia inducible factor, HIF-1.	Iron	86-90	Ferritin	Caenorhabditis elegans	30-35
23874015-4	2013	HO-1, a microsomal enzyme, catalyzes the breakdown of pro-oxidant heme, which is released from heme proteins to equimolar quantities of iron, carbon monoxide, and biliverdin.	Iron	136-140	heme oxygenase 1	Homo sapiens	0-4
23140858-2	2013	The enzyme heme oxygenase-1 (HO-1) generates three separate signaling molecules through the catalysis of heme - carbon monoxide (CO), biliverdin, and iron - each of which acts via distinct molecular targets to influence cell function, both proximally and distally.	Iron	150-154	heme oxygenase 1	Homo sapiens	11-27
23140858-2	2013	The enzyme heme oxygenase-1 (HO-1) generates three separate signaling molecules through the catalysis of heme - carbon monoxide (CO), biliverdin, and iron - each of which acts via distinct molecular targets to influence cell function, both proximally and distally.	Iron	150-154	heme oxygenase 1	Homo sapiens	29-33
22951294-1	2012	Hepcidin, a 25 amino-acid liver hormone, has recently emerged as the key regulator of iron homeostasis.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	0-8
22949628-8	2012	However, the distance between the OCH2 protons of the ethoxy group (site of phenacetin O-deethylation) and the heme iron was 1.5 A shorter in CYP1A2 than in CYP1A1.	Iron	116-120	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	142-148
19195055-1	2009	By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	14-22
19195055-1	2009	By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	14-22
19195055-1	2009	By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	14-22
22949628-8	2012	However, the distance between the OCH2 protons of the ethoxy group (site of phenacetin O-deethylation) and the heme iron was 1.5 A shorter in CYP1A2 than in CYP1A1.	Iron	116-120	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	157-163
22130959-0	2012	Is hemojuvelin a possible new player in iron metabolism in hemodialysis patients?	Iron	40-44	hemojuvelin BMP co-receptor	Homo sapiens	3-14
19130266-2	2009	This cellular iron efflux is modulated by the liver-derived peptide hepcidin, and this peptide is now regarded as the central regulator of body iron homeostasis.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	68-76
19130266-2	2009	This cellular iron efflux is modulated by the liver-derived peptide hepcidin, and this peptide is now regarded as the central regulator of body iron homeostasis.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	68-76
19130266-3	2009	Hepcidin expression is influenced by systemic stimuli such as iron stores, the rate of erythropoiesis, inflammation, hypoxia and oxidative stress.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
19013457-8	2009	Treatment of SH-SY5Y (human neuroblastoma) cells with an iron chelator resulted in increased density of A(2A)R.	Iron	57-61	adenosine A2a receptor	Homo sapiens	104-110
22130959-1	2012	INTRODUCTION: Hemojuvelin (HJV) is highly expressed in the liver, skeletal muscles, and heart, seems to play a role in iron absorption and release from cells, and has anti-inflammatory properties.	Iron	119-123	hemojuvelin BMP co-receptor	Homo sapiens	14-25
22130959-1	2012	INTRODUCTION: Hemojuvelin (HJV) is highly expressed in the liver, skeletal muscles, and heart, seems to play a role in iron absorption and release from cells, and has anti-inflammatory properties.	Iron	119-123	hemojuvelin BMP co-receptor	Homo sapiens	27-30
19144662-0	2009	Expression of hepcidin and other iron-related genes in type 3 hemochromatosis due to a novel mutation in transferrin receptor-2.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	14-22
22130959-2	2012	Moreover, HJV plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway.	Iron	100-104	hemojuvelin BMP co-receptor	Homo sapiens	10-13
19144662-0	2009	Expression of hepcidin and other iron-related genes in type 3 hemochromatosis due to a novel mutation in transferrin receptor-2.	Iron	33-37	transferrin receptor 2	Homo sapiens	105-127
22130959-2	2012	Moreover, HJV plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	59-67
19144662-6	2009	Urinary hepcidin was measured at baseline and after an oral iron challenge (ferrous sulfate, 65 mg) by SELDI-TOF-MS. A novel homozygous TFR2 mutation was identified in the splicing donor site of intron 4 (c.614+4 A>G) causing exon 4 skipping.	Iron	60-64	transferrin receptor 2	Homo sapiens	136-140
19144662-8	2009	Urinary hepcidin was lower than normal and further decreased after iron challenge.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	8-16
22130959-3	2012	Hepcidin has emerged as a key regulator of iron homeostasis.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
19144662-9	2009	This is the first description of iron-related gene expression profiles in a TFR2 mutated patient.	Iron	33-37	transferrin receptor 2	Homo sapiens	76-80
19144662-10	2009	The decreased hepatic and urinary expression of hepcidin and lack of acute response to iron challenge confirms the primary role of TFR2 in iron homeostasis.	Iron	139-143	transferrin receptor 2	Homo sapiens	131-135
22130959-4	2012	In this study we tested for the first time the hypothesis that HJV is related to iron metabolism in hemodialysis (HD) patients.	Iron	81-85	hemojuvelin BMP co-receptor	Homo sapiens	63-66
22130959-10	2012	CONCLUSIONS: Serum HJV is elevated in HD patients and related predominantly to kidney function and iron metabolism.	Iron	99-103	hemojuvelin BMP co-receptor	Homo sapiens	19-22
19907144-0	2009	The role of hepcidin in iron metabolism.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	12-20
22130959-12	2012	HJV appears to be a new player in iron metabolism in these patients.	Iron	34-38	hemojuvelin BMP co-receptor	Homo sapiens	0-3
19907144-1	2009	Hepcidin is the central regulator of systemic iron homeostasis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
22885719-2	2012	The rs855791 polymorphism, encoding for the p.A736V variant of TMPRSS6 regulating hepcidin, influences iron status in the population.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	82-90
19907144-3	2009	Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
19907144-3	2009	Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
19907145-2	2009	The key protein in iron homeostasis is a 25-amino-acid peptide, hepcidin, which modulates the amount of iron in the circulation by binding and promoting the degradation of the iron exporter ferroportin.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	64-72
19907145-2	2009	The key protein in iron homeostasis is a 25-amino-acid peptide, hepcidin, which modulates the amount of iron in the circulation by binding and promoting the degradation of the iron exporter ferroportin.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	64-72
19907145-2	2009	The key protein in iron homeostasis is a 25-amino-acid peptide, hepcidin, which modulates the amount of iron in the circulation by binding and promoting the degradation of the iron exporter ferroportin.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	64-72
19907145-3	2009	Given the central importance of hepcidin, recent studies have focused on how iron is sensed and how the iron signal is transmitted to hepcidin.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	134-142
19907147-4	2009	Hepcidin is the master regulator of iron homeostasis and its synthesis is inhibited by iron deficiency and stimulated by inflammation.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
23045394-2	2012	Aft1p is regulated by accelerated nuclear export in the presence of iron, mediated by Msn5p.	Iron	68-72	karyopherin MSN5	Saccharomyces cerevisiae S288C	86-91
19907151-3	2009	The first includes juvenile and TFR2-related hemochromatoses that, similar to HFE hemochromatosis, show recessive inheritance, increased transferrin saturation, iron storage in hepatocytes and responsiveness to phlebotomy.	Iron	161-165	transferrin receptor 2	Homo sapiens	32-36
19907151-5	2009	The second subgroup of hemochromatosis is caused by autosomal dominant mutations in the SLC40A1 gene encoding the iron exporter ferroportin with distinctive features.	Iron	114-118	solute carrier family 40 member 1	Homo sapiens	88-95
19907155-3	2009	Improved understanding of how iron metabolism is controlled by proteins such as hepcidin, ferroportin, hypoxia-inducible factor 1, and growth differentiation factor 15 have revealed how they are involved in the organ toxicity of SCD.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	80-88
23134421-0	2012	Tuning the reactivity of TEMPO by coordination to a Lewis acid: isolation and reactivity of MCl3(eta1-TEMPO) (M = Fe, Al).	Iron	114-116	secreted phosphoprotein 1	Homo sapiens	97-101
18974313-0	2009	Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium.	Iron	0-4	hephaestin	Rattus norvegicus	39-49
18974313-2	2009	Ferroportin 1 (FPN1) and hephaestin (Heph) are necessary for transport of iron out of enterocytes, but it is not known whether these two proteins interact during iron absorption.	Iron	74-78	hephaestin	Rattus norvegicus	25-35
22993068-2	2012	This study tested whether acute kidney injury (AKI) triggers renal Hpx accumulation, potentially impacting heme Fe-mediated tubular injury.	Iron	112-114	hemopexin	Mus musculus	67-70
18974313-2	2009	Ferroportin 1 (FPN1) and hephaestin (Heph) are necessary for transport of iron out of enterocytes, but it is not known whether these two proteins interact during iron absorption.	Iron	74-78	hephaestin	Rattus norvegicus	37-41
18974313-5	2009	Heph exhibited a similar though less prominent migration after iron ingestion.	Iron	63-67	hephaestin	Rattus norvegicus	0-4
18974313-7	2009	Thus the data indicate that FPN1 and Heph migrate and interact during iron feeding and suggest that dimeric FPN1 is associated with intact Heph.	Iron	70-74	hephaestin	Rattus norvegicus	37-41
22993068-8	2012	Paradoxically, in cultured renal cells (HK-2, HEK-293), Fe depletion, and not free heme excess, increased Hpx mRNA.	Iron	56-58	hemopexin	Mus musculus	106-109
22993068-14	2012	Given its ability to bind free heme and mitigate free Fe toxicity, Hpx loading can potentially confer cytoprotective effects.	Iron	54-56	hemopexin	Mus musculus	67-70
19400694-1	2009	Hepcidin, a 25-amino-acid antimicrobial peptide, is the central regulator of iron homeostasis.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
19400694-2	2009	Hepcidin transcription is upregulated by inflammatory cytokines, iron, and bone morphogenetic proteins and is downregulated by iron deficiency, ineffective erythropoiesis, and hypoxia.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	0-8
19400694-4	2009	Except for inherited defects of ferroportin and hepcidin itself, all forms of iron-storage disease appear to arise from hepcidin dysregulation.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	120-128
23026080-5	2012	Matriptase-2 represents an important regulatory protease in iron homeostasis by down-regulation of the hepcidin expression.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	103-111
19400694-6	2009	Knowledge of the regulation of hepcidin by inflammation, iron, erythropoiesis, and hypoxia will lead to an understanding of the pathogenesis of primary hemochromatosis, secondary iron overload, and anemia of inflammatory disease.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	31-39
19400694-6	2009	Knowledge of the regulation of hepcidin by inflammation, iron, erythropoiesis, and hypoxia will lead to an understanding of the pathogenesis of primary hemochromatosis, secondary iron overload, and anemia of inflammatory disease.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	31-39
22609894-11	2012	CONCLUSIONS: In CHF patients without anemia, the increase in the inflammatory state (sTNFRI) and the following deterioration in the iron metabolism (hepcidin) were the main determinants of a decrease in hemoglobin and the appearance of anemia in the long term follow-up period.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	149-157
18495462-2	2009	Hepcidin is a peptide shown to be the principal regulator of the absorption and systemic distribution of iron.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
18495462-3	2009	Main inducers of hepcidin are iron overload, hypoxia and inflammation, where the latter has been linked to hepcidin via increased interleukin-6 (IL-6).	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	17-25
19713706-1	2009	Hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from the macrophages.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
19713706-1	2009	Hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from the macrophages.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
19713706-1	2009	Hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from the macrophages.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
19713706-8	2009	In conclusion, hepcidin levels are influenced by iron supplementation in HD patients.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	15-23
19713706-10	2009	It remains to be seen if assay of hepcidin will be of help in identifying patients unresponsive to oral iron or requiring intravenous iron supplementation.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	34-42
22611049-1	2012	UNLABELLED: Hepcidin regulation is linked to both iron and inflammatory signals and may influence iron loading in nonalcoholic steatohepatitis (NASH).	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	12-20
18785996-9	2009	NDF4 protein was predicted to possess a redox-active iron-sulfur cluster domain that may be involved in the electron transfer.	Iron	53-57	NDH-dependent cyclic electron flow 1	Arabidopsis thaliana	0-4
22611049-1	2012	UNLABELLED: Hepcidin regulation is linked to both iron and inflammatory signals and may influence iron loading in nonalcoholic steatohepatitis (NASH).	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	12-20
22611049-6	2012	Subjects with hepatic iron deposition had higher serum hepcidin levels than subjects without iron for all HFE genotypes (P &lt; 0.0001).	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	55-63
19238200-2	2009	Increased hepcidin concentrations lead to iron sequestration in macrophages, contributing to the pathogenesis of anaemia of chronic disease whereas decreased hepcidin is observed in iron deficiency and primary iron overload diseases such as hereditary hemochromatosis.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	10-18
22611049-7	2012	Hepcidin levels were highest among patients with mixed HC/reticuloendothelial system cell (RES) iron deposition.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	0-8
22611049-10	2012	CONCLUSIONS: The presence of C282Y mutations in patients with NAFLD is associated with greater HC iron deposition and decreased serum hepcidin levels, and there is a positive relationship between hepatic iron stores and serum hepcidin level across all HFE genotypes.	Iron	204-208	hepcidin antimicrobial peptide	Homo sapiens	226-234
22611049-11	2012	These data suggest that body iron stores are the major determinant of hepcidin regulation in NAFLD, regardless of HFE genotype.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	70-78
22591204-9	2012	The HFD with iron synergistically induced mRNA expression of Pparalpha targets, including Acox and Cpt1 in wild-type mice, yet the induction was diminished in Nrf2-null mice.	Iron	13-17	carnitine palmitoyltransferase 1b, muscle	Mus musculus	99-103
19250447-0	2009	The role of hepcidin in iron homeostasis and anemia in hemodialysis patients.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	12-20
19250447-5	2009	Hepcidin production is regulated by hypoxia/anemia, iron status, and importantly, inflammation.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
19250447-7	2009	The decreased availability of iron for erythropoiesis leads to the anemia of chronic disease or, in HD patients, aggravate an already existing anemia HD is now widely considered an inflammatory state probably accounting for the increased serum hepcidin levels that have been associated with it.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	244-252
22923613-1	2012	Human heme oxygenases 1 and 2 (HO-1 and HO-2) degrade heme in the presence of oxygen and NADPH-cytochrome P450 reductase, producing ferrous iron, CO, and biliverdin.	Iron	140-144	heme oxygenase 1	Homo sapiens	6-29
18957412-2	2008	We have characterized a plant P loop NTPase with sequence similarity to Nbp35 of yeast and mammals, a protein of the cytosolic Cfd1-Nbp35 complex mediating Fe-S cluster assembly.	Iron	156-160	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	72-77
18957412-2	2008	We have characterized a plant P loop NTPase with sequence similarity to Nbp35 of yeast and mammals, a protein of the cytosolic Cfd1-Nbp35 complex mediating Fe-S cluster assembly.	Iron	156-160	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	127-131
18957412-2	2008	We have characterized a plant P loop NTPase with sequence similarity to Nbp35 of yeast and mammals, a protein of the cytosolic Cfd1-Nbp35 complex mediating Fe-S cluster assembly.	Iron	156-160	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	132-137
18957412-4	2008	Moreover, plant and algal NBP35 proteins lack the characteristic CXXC motif in the C terminus, thought to be required for Fe-S cluster binding.	Iron	122-126	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	26-31
22923613-1	2012	Human heme oxygenases 1 and 2 (HO-1 and HO-2) degrade heme in the presence of oxygen and NADPH-cytochrome P450 reductase, producing ferrous iron, CO, and biliverdin.	Iron	140-144	heme oxygenase 1	Homo sapiens	31-44
22426798-9	2012	Hepcidin mRNA expression was increased in OBDM with anemia even in basal Fe concentration, and mitofusin 2 was decreased in all experimental conditions.	Iron	73-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
18951467-3	2008	We demonstrate that low urinary hepcidin, likely due to impaired iron delivery to erythroid cells via the transferrin cycle pathway over time, may be the mechanism for iron loading.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	32-40
18951467-3	2008	We demonstrate that low urinary hepcidin, likely due to impaired iron delivery to erythroid cells via the transferrin cycle pathway over time, may be the mechanism for iron loading.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	32-40
23170109-2	2012	Anemia is one of the main clinical features in patients with multiple myeloma (MM) and hepcidin may be associated with iron homeostasis in these patients.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	87-95
18775801-0	2008	Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	23-31
18775801-1	2008	Hepcidin is a small liver-derived peptide central in the regulation of systemic iron homeostasis.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
18775801-9	2008	An unexpected observation was the synergistic effect of BMPs and IL-6 on hepcidin-25 secretion, which points towards cross-talk between iron and inflammatory stimuli.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	73-81
18775801-10	2008	The study underscores hepcidin-25 quantification as a valuable tool to unravel regulatory pathways in iron metabolism.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	22-30
19256381-2	2008	Reductive dechlorination of toxic pollutants of CCl4 in water with Fe0 and amended Fe0 by batch experiments was investigated.	Iron	67-70	C-C motif chemokine ligand 4	Homo sapiens	48-52
19256381-2	2008	Reductive dechlorination of toxic pollutants of CCl4 in water with Fe0 and amended Fe0 by batch experiments was investigated.	Iron	83-86	C-C motif chemokine ligand 4	Homo sapiens	48-52
22419571-1	2012	Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin.	Iron	88-92	heme oxygenase 1	Homo sapiens	0-16
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	148-151	C-C motif chemokine ligand 4	Homo sapiens	16-20
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	148-151	C-C motif chemokine ligand 4	Homo sapiens	131-135
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	148-150	C-C motif chemokine ligand 4	Homo sapiens	16-20
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	148-150	C-C motif chemokine ligand 4	Homo sapiens	131-135
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	156-158	C-C motif chemokine ligand 4	Homo sapiens	16-20
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	156-158	C-C motif chemokine ligand 4	Homo sapiens	131-135
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	156-158	C-C motif chemokine ligand 4	Homo sapiens	16-20
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	156-158	C-C motif chemokine ligand 4	Homo sapiens	131-135
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	156-158	C-C motif chemokine ligand 4	Homo sapiens	16-20
22955522-5	2012	Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, ALK, CIAO1, NOTCH3 in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference method and our programming.	Iron	136-140	notch receptor 3	Homo sapiens	215-221
19256381-4	2008	The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0.0393, 0.0925, 0.158, 0.0496 and 0.0533 min(-1) respectively.	Iron	156-158	C-C motif chemokine ligand 4	Homo sapiens	131-135
19256381-5	2008	The byproducts and pathway of dechlorination of CCl4 by Fe0 and amended Fe0 was identified by GC/MS.	Iron	56-59	C-C motif chemokine ligand 4	Homo sapiens	48-52
19256381-5	2008	The byproducts and pathway of dechlorination of CCl4 by Fe0 and amended Fe0 was identified by GC/MS.	Iron	72-75	C-C motif chemokine ligand 4	Homo sapiens	48-52
22881289-2	2012	The stress protein, HO-1 mediates the degradation of cellular heme to biliverdin/bilirubin, free iron, and CO and is up-regulated in the brains of persons with Alzheimer"s disease and Parkinson"s disease.	Iron	97-101	heme oxygenase 1	Homo sapiens	20-24
22676252-1	2012	BACKGROUND: Serum hepcidin concentration is potentially affected by inflammation and iron stores in chronic liver disease (CLD), but little is known about the relationship between hepcidin and the degree of hepatic fibrosis.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	18-26
19046123-2	2008	The present study was undertaken to assess whether tolerance can be induced pharmacologically by deferroxamine (DFX), an iron chelator, which promotes the expression of the transcription factor, hypoxia-inducible factor 1-alpha (HIF-1alpha), and to identify potential HIF-1alpha -induced effectors of this endogenous protective response.	Iron	121-125	hypoxia inducible factor 1, alpha subunit	Mus musculus	195-227
22734611-0	2012	Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy.	Iron	58-62	lactotransferrin	Bos taurus	80-91
19034258-4	2008	Hepcidin is an iron regulatory hormone that inhibits ferroportin-mediated iron export from enterocytes and macrophages.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
22734611-1	2012	AIM: To develop polymeric-ceramic nanocarriers (NCs) in order to achieve oral delivery of the anticancer neutraceutical iron-saturated bovine lactoferrin (Fe-bLf) protein.	Iron	120-124	lactotransferrin	Bos taurus	142-153
22815544-1	2012	BACKGROUND: Measurement of serum hepcidin levels may provide a useful alternative to the current methods of determining iron status in chronic haemodialysis (HD) patients.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	33-41
18834167-1	2008	Lactoferrin (LF) is an iron-binding glycoprotein that possesses multifunctional biological activities.	Iron	23-27	lactotransferrin	Bos taurus	0-11
18834167-1	2008	Lactoferrin (LF) is an iron-binding glycoprotein that possesses multifunctional biological activities.	Iron	23-27	lactotransferrin	Bos taurus	13-15
22815544-12	2012	These findings need to be taken into account in future studies assessing the utility of serum hepcidin as a guide to the use of iron or erythropoiesis-stimulating agents therapy.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	94-102
18923425-3	2008	In Saccharomyces cerevisiae, the Cth2 protein stimulates the decay of target ARE mRNAs on iron starvation.	Iron	90-94	Tis11p	Saccharomyces cerevisiae S288C	33-37
22525981-3	2012	The recent identification of hepcidin sheds new light into the crucial role of iron homeostasis in bone metabolism.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	29-37
23043051-8	2012	CGLD27/At5g67370 is a highly conserved, presumed chloroplast-localized pioneer protein and is important for growth of Arabidopsis thaliana in low iron.	Iron	146-150	DUF1230 family protein (DUF1230)	Arabidopsis thaliana	0-6
18664504-1	2008	BACKGROUND AND AIMS: Hepcidin is an iron homoeostasis regulator peptide.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	21-29
18586877-13	2008	Systemic injection of the iron chelator, 1,10-phenanthroline prevented the degradation of HIF-1alpha and reduced oxygen-induced proliferation.	Iron	26-30	hypoxia inducible factor 1, alpha subunit	Mus musculus	90-100
23055972-8	2012	The divalent metal transporter-1 (DMT1) is involved in the uptake of both iron and copper.	Iron	74-78	solute carrier family 11 member 2	Homo sapiens	4-32
18620776-1	2008	BACKGROUND/AIMS: The aim of this study is to determine the clinical relevance of hepatic producing iron regulatory hormone-hepcidin, on iron overload in patients with chronic hepatitis C (CHC).	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	123-131
18620776-4	2008	RESULTS: Serum hepcidin was positively correlated with hepatic hepcidin mRNA levels, serum ferritin and the degree of hepatic iron deposition in CHC.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	15-23
18620776-6	2008	This relative impairment of hepcidin production was fully reversible after successful HCV eradication by PEG-IFN plus ribavirin, concomitantly with the improvement of the iron overload condition.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	28-36
18620776-7	2008	CONCLUSIONS: The impairment of hepatic hepcidin production occurring with chronic HCV infection may enhance iron toxicity and lead to disease progression, and modulation or supplementation of hepcidin may be beneficial for these conditions in CHC.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	39-47
23055972-8	2012	The divalent metal transporter-1 (DMT1) is involved in the uptake of both iron and copper.	Iron	74-78	solute carrier family 11 member 2	Homo sapiens	34-38
23055972-9	2012	Furthermore, copper is an essential co-factor in numerous proteins that are vital for iron homeostasis and affects the binding of iron-response proteins to iron-response elements in the mRNA of the transferrin receptor, DMT1, and ferroportin, all highly involved in iron transport.	Iron	130-134	solute carrier family 11 member 2	Homo sapiens	220-224
18936232-0	2008	Hepcidin regulation of iron transport.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
23055972-9	2012	Furthermore, copper is an essential co-factor in numerous proteins that are vital for iron homeostasis and affects the binding of iron-response proteins to iron-response elements in the mRNA of the transferrin receptor, DMT1, and ferroportin, all highly involved in iron transport.	Iron	130-134	solute carrier family 11 member 2	Homo sapiens	220-224
22993514-0	2012	Iron Biofortification and Homeostasis in Transgenic Cassava Roots Expressing the Algal Iron Assimilatory Gene, FEA1.	Iron	87-91	uncharacterized protein	Chlamydomonas reinhardtii	111-115
18936232-1	2008	The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	17-25
18936232-2	2008	Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	14-22
18936232-2	2008	Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	14-22
18936232-4	2008	A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	100-108
18936232-4	2008	A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	100-108
22993514-1	2012	We have engineered the tropical root crop cassava (Manihot esculenta) to express the Chlamydomonas reinhardtii iron assimilatory gene, FEA1, in its storage roots with the objective of enhancing the root nutritional qualities.	Iron	111-115	uncharacterized protein	Chlamydomonas reinhardtii	135-139
22993514-5	2012	Transgenic plants also had normal levels of zinc in leaves and roots consistent with the specific uptake of ferrous iron mediated by the FEA1 protein.	Iron	108-120	uncharacterized protein	Chlamydomonas reinhardtii	137-141
18715869-0	2008	The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.	Iron	129-133	Tis11p	Saccharomyces cerevisiae S288C	4-8
22993514-6	2012	Relative to wild-type plants, fibrous roots of FEA1 expressing plants had reduced Fe (III) chelate reductase activity consistent with the more efficient uptake of iron in the transgenic plants.	Iron	163-167	uncharacterized protein	Chlamydomonas reinhardtii	47-51
18715869-2	2008	In response to iron deficiency, the budding yeast Saccharomyces cerevisiae induces the expression of the Cth1 and Cth2 mRNA-binding proteins to promote a genome-wide remodeling of cellular metabolism that contributes to the optimal utilization of iron.	Iron	15-19	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	105-109
18715869-2	2008	In response to iron deficiency, the budding yeast Saccharomyces cerevisiae induces the expression of the Cth1 and Cth2 mRNA-binding proteins to promote a genome-wide remodeling of cellular metabolism that contributes to the optimal utilization of iron.	Iron	15-19	Tis11p	Saccharomyces cerevisiae S288C	114-118
18715869-2	2008	In response to iron deficiency, the budding yeast Saccharomyces cerevisiae induces the expression of the Cth1 and Cth2 mRNA-binding proteins to promote a genome-wide remodeling of cellular metabolism that contributes to the optimal utilization of iron.	Iron	247-251	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	105-109
23002334-5	2012	The present review will first discuss how iron might directly interact with the metabolism of hepatic lipids and then consider a new perspective on the way in which iron may have a role in the two hit hypothesis for the progression of NAFLD via ferroportin and the iron regulatory molecule hepcidin.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	290-298
18715869-2	2008	In response to iron deficiency, the budding yeast Saccharomyces cerevisiae induces the expression of the Cth1 and Cth2 mRNA-binding proteins to promote a genome-wide remodeling of cellular metabolism that contributes to the optimal utilization of iron.	Iron	247-251	Tis11p	Saccharomyces cerevisiae S288C	114-118
18715869-6	2008	We demonstrate that the degradation of succinate dehydrogenase SDH4 mRNA, a known target of Cth2 on iron-deficient conditions, depends on Dhh1.	Iron	100-104	Tis11p	Saccharomyces cerevisiae S288C	92-96
23002334-5	2012	The present review will first discuss how iron might directly interact with the metabolism of hepatic lipids and then consider a new perspective on the way in which iron may have a role in the two hit hypothesis for the progression of NAFLD via ferroportin and the iron regulatory molecule hepcidin.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	290-298
22632602-1	2012	The proximal cavity mutant of myoglobin consists of a mutation of the proximal histidine to glycine (H93G), which permits exogenous ligands to bind to the heme iron.	Iron	160-164	myoglobin	Homo sapiens	30-39
18619468-4	2008	In this work, we identify a striking sequence-structure similarity of hPMS2 to the metal-binding/dimerization domain of the iron-dependent repressor protein family and present a structural model of the metal-binding domain of MutLalpha.	Iron	124-128	PMS1 homolog 2, mismatch repair system component	Homo sapiens	70-75
18755804-2	2008	This study tested the hypothesis that gastrin and iron status are interrelated by measurement of iron homeostasis in mice and humans with abnormal circulating gastrin concentrations.	Iron	50-54	gastrin	Homo sapiens	159-166
22460343-2	2012	In this study we examined abnormal phase values, indicative of increased iron content on SWI-filtered phase images of the SDGM in CIS patients and HC.	Iron	73-77	cytokine inducible SH2 containing protein	Homo sapiens	130-133
18823621-3	2008	Redox active metal ions such as iron (Fe) and copper (Cu) are known to enhance alpha-synuclein fibrillogenesis.	Iron	32-36	synuclein alpha	Homo sapiens	79-94
18823621-3	2008	Redox active metal ions such as iron (Fe) and copper (Cu) are known to enhance alpha-synuclein fibrillogenesis.	Iron	38-40	synuclein alpha	Homo sapiens	79-94
22460343-12	2012	CONCLUSION: Patients with CIS showed significantly increased content and volume of iron, as determined by abnormal SWI-phase measurement, in the various SDGM structures, suggesting that iron deposition may precede structure-specific  atrophy.	Iron	83-87	cytokine inducible SH2 containing protein	Homo sapiens	26-29
22460343-12	2012	CONCLUSION: Patients with CIS showed significantly increased content and volume of iron, as determined by abnormal SWI-phase measurement, in the various SDGM structures, suggesting that iron deposition may precede structure-specific  atrophy.	Iron	186-190	cytokine inducible SH2 containing protein	Homo sapiens	26-29
18769232-1	2008	PURPOSE OF REVIEW: Heme oxygenase-1 apart from converting heme to carbon monoxide, iron and biliverdin has been shown to exert anti-inflammatory, antiapoptotic and antioxidant actions.	Iron	83-87	heme oxygenase 1	Homo sapiens	19-35
22306005-5	2012	In the efferent arc, hepcidin regulates intestinal iron absorption, plasma iron concentrations, and tissue iron distribution by inducing degradation of its receptor, the cellular iron exporter ferroportin.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	21-29
18827264-2	2008	As a co-receptor of bone morphogenetic protein, membrane hemojuvelin positively modulates the iron regulator hepcidin.	Iron	94-98	hemojuvelin BMP co-receptor	Homo sapiens	57-68
18827264-2	2008	As a co-receptor of bone morphogenetic protein, membrane hemojuvelin positively modulates the iron regulator hepcidin.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	109-117
18827264-3	2008	Mutations of the gene encoding for hemojuvelin cause juvenile hemochromatosis, characterized by hepcidin deficiency and severe iron overload.	Iron	127-131	hemojuvelin BMP co-receptor	Homo sapiens	35-46
22306005-5	2012	In the efferent arc, hepcidin regulates intestinal iron absorption, plasma iron concentrations, and tissue iron distribution by inducing degradation of its receptor, the cellular iron exporter ferroportin.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	21-29
22306005-7	2012	In the more complex and less well understood afferent arc, hepatic hepcidin synthesis is transcriptionally regulated by extracellular and intracellular iron concentrations through a molecular complex of bone morphogenetic protein receptors and their iron-specific ligands, modulators and iron sensors.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	67-75
22306005-7	2012	In the more complex and less well understood afferent arc, hepatic hepcidin synthesis is transcriptionally regulated by extracellular and intracellular iron concentrations through a molecular complex of bone morphogenetic protein receptors and their iron-specific ligands, modulators and iron sensors.	Iron	250-254	hepcidin antimicrobial peptide	Homo sapiens	67-75
22306005-7	2012	In the more complex and less well understood afferent arc, hepatic hepcidin synthesis is transcriptionally regulated by extracellular and intracellular iron concentrations through a molecular complex of bone morphogenetic protein receptors and their iron-specific ligands, modulators and iron sensors.	Iron	250-254	hepcidin antimicrobial peptide	Homo sapiens	67-75
18713659-7	2008	The I152F, normally localized on cell membrane and internalized by hepcidin, showed a unique "primary" deficit of iron export capability.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	67-75
22306005-8	2012	Through as yet undefined pathways, hepcidin is also homeostatically regulated by the iron requirements of erythroid precursors for hemoglobin synthesis.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	35-43
22306005-9	2012	In accordance with the role of hepcidin-mediated iron redistribution in host defense, hepcidin production is regulated by inflammation as well.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	31-39
22306005-10	2012	Increased hepcidin concentrations in plasma are pathogenic in iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	10-18
22306005-11	2012	Hepcidin deficiency causes iron overload in hereditary hemochromatosis and ineffective erythropoiesis.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
18597060-6	2008	OxVLDL modified by copper or iron ions increased the expression of PAI-1 and HSF1 in EC compared to VLDL or LDL.	Iron	29-33	serpin family E member 1	Homo sapiens	67-72
22564156-3	2012	Hence, the ability of exogenously-added copper, iron and zinc to influence HO-1 expression in HCT-116 cells was evaluated.	Iron	48-52	heme oxygenase 1	Homo sapiens	75-79
18282164-2	2008	Because ceruloplasmin functions in iron transport and storage, aceruloplasminemia leads to excessive iron accumulation systemically and within the CNS.	Iron	35-39	ceruloplasmin	Homo sapiens	8-21
22137264-4	2012	We show that divalent metal transporter-1 (DMT-1) delocalizes from the plasma membrane upon iron or zinc depletion, but its apical abundance increases with zinc supplementation.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	13-41
18282164-2	2008	Because ceruloplasmin functions in iron transport and storage, aceruloplasminemia leads to excessive iron accumulation systemically and within the CNS.	Iron	101-105	ceruloplasmin	Homo sapiens	8-21
18712936-0	2008	Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis.	Iron	40-44	lactotransferrin	Mus musculus	61-67
18712936-5	2008	A recombinant mutant of the mICA (W124R/S188Y) was created with the goal of restoring the ligands required for both anion (Arg124) and iron (Tyr188) binding in the N-lobe.	Iron	135-139	lactotransferrin	Mus musculus	164-170
22137264-4	2012	We show that divalent metal transporter-1 (DMT-1) delocalizes from the plasma membrane upon iron or zinc depletion, but its apical abundance increases with zinc supplementation.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	43-48
18712936-9	2008	Induction of specific iron binding implies that (1) the structure of mICA resembles those of other TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron binds.	Iron	22-26	lactotransferrin	Mus musculus	129-135
18712936-9	2008	Induction of specific iron binding implies that (1) the structure of mICA resembles those of other TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron binds.	Iron	192-196	lactotransferrin	Mus musculus	129-135
22137264-5	2012	This translocation of DMT-1 coincides with an increase in iron uptake upon zinc supplementation, as previously reported by us.	Iron	58-62	solute carrier family 11 member 2	Homo sapiens	22-27
18552213-11	2008	We conclude that STAT5A/B is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 transcription.	Iron	55-59	signal transducer and activator of transcription 5A	Mus musculus	17-25
18585019-0	2008	Protective effects of GH and IGF-I against iron-induced lipid peroxidation in vivo.	Iron	43-47	insulin-like growth factor 1	Rattus norvegicus	29-34
22137264-6	2012	FPN-1 expression increases upon zinc supplementation and decreases with iron or zinc depletion, effluxing the excess sequestered iron and thus maintaining cellular iron homeostasis.	Iron	72-76	solute carrier family 40 member 1	Homo sapiens	0-5
22137264-6	2012	FPN-1 expression increases upon zinc supplementation and decreases with iron or zinc depletion, effluxing the excess sequestered iron and thus maintaining cellular iron homeostasis.	Iron	129-133	solute carrier family 40 member 1	Homo sapiens	0-5
19112848-4	2008	In this paper, the effect of alcohol on hepcidin expression which is a key hormone in the regulation of iron metabolism has been given.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	40-48
22137264-6	2012	FPN-1 expression increases upon zinc supplementation and decreases with iron or zinc depletion, effluxing the excess sequestered iron and thus maintaining cellular iron homeostasis.	Iron	129-133	solute carrier family 40 member 1	Homo sapiens	0-5
19112848-5	2008	Hepcidin regulates of iron metabolism by inhibiting intestinal iron absorption and the release of iron from macrophages.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
19112848-5	2008	Hepcidin regulates of iron metabolism by inhibiting intestinal iron absorption and the release of iron from macrophages.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
22819264-1	2012	INTRODUCTION: Heme oxygenase-1 (HO-1) is the rate limiting enzyme that catalyzes the conversion of heme into biliverdin, free iron, and carbon monoxide (CO).	Iron	126-130	heme oxygenase 1	Homo sapiens	14-30
19112848-5	2008	Hepcidin regulates of iron metabolism by inhibiting intestinal iron absorption and the release of iron from macrophages.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
22736759-1	2012	Divalent metal-ion transporter-1 (DMT1) is a H(+)-coupled metal-ion transporter that plays essential roles in iron homeostasis.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	0-32
18447830-5	2008	This interaction was investigated further by computer modelling and, based on the sequence similarity of hepcidin with metallothionein, a three-dimensional model of hepcidin, containing one atom of iron, was constructed.	Iron	198-202	hepcidin antimicrobial peptide	Homo sapiens	165-173
18447830-7	2008	Monoferric hepcidin was identified by MS, as were possibly other complexes containing two and three atoms of iron respectively, although these were present only in minor amounts.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	11-19
18447830-9	2008	EPR spectroscopy identified the ferric state of the bound metal, and indicated that the iron-hepcidin complex shares some similarities with the rubredoxin iron-sulfur complex, suggesting the presence of Fe(3+) in a tetrahedral sulfur co-ordination.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	93-101
18447830-9	2008	EPR spectroscopy identified the ferric state of the bound metal, and indicated that the iron-hepcidin complex shares some similarities with the rubredoxin iron-sulfur complex, suggesting the presence of Fe(3+) in a tetrahedral sulfur co-ordination.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	93-101
18447830-10	2008	The potential roles of iron binding for hepcidin are discussed, and we propose either a regulatory function in the maturation of pro-hepcidin into active hepcidin or as the necessary link in the interaction between hepcidin and ferroportin.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	40-48
22736759-1	2012	Divalent metal-ion transporter-1 (DMT1) is a H(+)-coupled metal-ion transporter that plays essential roles in iron homeostasis.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	34-38
22736759-6	2012	Radiotracer and continuous measurement of transport by fluorescence assays revealed that DMT1 mediates the transport of several metal ions that were ranked in selectivity by using the ratio I(max)/K(0.5) (determined from evoked currents at -70 mV): Cd(2+) &gt; Fe(2+) &gt; Co(2+), Mn(2+) &gt;&gt; Zn(2+), Ni(2+), VO(2+).	Iron	261-263	solute carrier family 11 member 2	Homo sapiens	89-93
22884366-2	2012	In this study, we show that after Apc deletion, the cellular iron acquisition proteins TfR1 and DMT1 are rapidly induced.	Iron	61-65	doublesex and mab-3 related transcription factor 1	Homo sapiens	96-100
18680715-1	2008	Mammalian iron homeostasis is regulated by the interaction of the liver-produced peptide hepcidin and its receptor, the iron transporter ferroportin.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	89-97
22659878-9	2012	However, in contrast to the role of NQO1 in vitro, we demonstrate that NE-treated Nqo1-null mice had greater levels of BAL and lung tissue lipid carbonyls and greater BAL iron on day 11, all consistent with increased oxidative stress.	Iron	171-175	elastase, neutrophil expressed	Mus musculus	71-73
18680715-2	2008	Hepcidin binds to ferroportin resulting in degradation of ferroportin and decreased cellular iron export.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	0-8
18664788-0	2008	Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia.	Iron	64-68	erythropoietin	Mus musculus	16-30
18641331-10	2008	In addition, hemopexin-null mice had reduced transferrin receptor 1 expression in T cells, possibly due to the increase in heme-derived iron.	Iron	136-140	hemopexin	Mus musculus	13-22
18641331-12	2008	Our data suggest that hemopexin, by controlling heme-iron availability in lymphocytes, modulates responsiveness to IFN-gamma and, hence, autoimmune responses.	Iron	53-57	hemopexin	Mus musculus	22-31
18627600-11	2008	It revealed the transcriptional regulation of PDR1 by Rpn4p, proposed a new role for the pleiotropic drug resistance network in stress response and demonstrated a direct regulatory connection between oxidative stress response and iron homeostasis.	Iron	230-234	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	46-50
18487208-2	2008	Human heme oxygenase-1 (hHO-1) catalyzes the O2- and NADPH-dependent oxidation of heme to biliverdin, CO, and free iron.	Iron	115-119	heme oxygenase 1	Homo sapiens	6-22
18487208-2	2008	Human heme oxygenase-1 (hHO-1) catalyzes the O2- and NADPH-dependent oxidation of heme to biliverdin, CO, and free iron.	Iron	115-119	heme oxygenase 1	Homo sapiens	24-29
18273906-6	2008	Intravenous iron has been shown to overcome hepcidin induced iron restricted erythropoiesis in iron-replete patients.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	44-52
18273906-6	2008	Intravenous iron has been shown to overcome hepcidin induced iron restricted erythropoiesis in iron-replete patients.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	44-52
18273906-6	2008	Intravenous iron has been shown to overcome hepcidin induced iron restricted erythropoiesis in iron-replete patients.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	44-52
18594779-2	2008	There is a sophisticated balance of body iron metabolism of storage and transport, which is regulated by several factors including the newly identified peptide hepcidin.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	160-168
18326691-3	2008	In prior studies, both iron overload and features of AMD were identified in mice deficient in the ferroxidase ceruloplasmin (Cp) and its homologue hephaestin (Heph) (double knockout, DKO).	Iron	23-27	ceruloplasmin	Mus musculus	110-123
18503700-0	2008	Serum pro-hepcidin as an indicator of iron status in dialysis patients.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	10-18
18485875-4	2008	Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions.	Iron	100-104	NADH:ubiquinone oxidoreductase core subunit S3	Homo sapiens	89-95
18469261-5	2008	RESULTS: The hepatic expressions of the iron-export protein ferroportin-1 (FP-1) and of the iron-sensing molecule hemojuvelin (HJV) were significantly lower in NAFLD patients.	Iron	40-44	solute carrier family 40 member 1	Homo sapiens	60-73
18469261-5	2008	RESULTS: The hepatic expressions of the iron-export protein ferroportin-1 (FP-1) and of the iron-sensing molecule hemojuvelin (HJV) were significantly lower in NAFLD patients.	Iron	40-44	solute carrier family 40 member 1	Homo sapiens	75-79
18469261-5	2008	RESULTS: The hepatic expressions of the iron-export protein ferroportin-1 (FP-1) and of the iron-sensing molecule hemojuvelin (HJV) were significantly lower in NAFLD patients.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	114-125
18469261-5	2008	RESULTS: The hepatic expressions of the iron-export protein ferroportin-1 (FP-1) and of the iron-sensing molecule hemojuvelin (HJV) were significantly lower in NAFLD patients.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	127-130
18469261-6	2008	The mRNA expression of the iron-regulatory peptide hepcidin was increased in NAFLD patients with iron overload, which was paralleled by low duodenal FP-1 expression.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	51-59
18469261-6	2008	The mRNA expression of the iron-regulatory peptide hepcidin was increased in NAFLD patients with iron overload, which was paralleled by low duodenal FP-1 expression.	Iron	27-31	solute carrier family 40 member 1	Homo sapiens	149-153
18469261-10	2008	CONCLUSIONS: Iron accumulation in NAFLD may result from an impaired iron export due to down-regulation of FP1 and ineffective hepatic iron sensing, as indicated by low HJV expression.	Iron	13-17	hemojuvelin BMP co-receptor	Homo sapiens	168-171
18469261-12	2008	Increased hepcidin formation in iron-overloaded NAFLD patients, however, results in decreased duodenal FP-1 expression, whereas a reduction in liver FP-1 may perpetuate hepatic iron retention.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	10-18
18469261-12	2008	Increased hepcidin formation in iron-overloaded NAFLD patients, however, results in decreased duodenal FP-1 expression, whereas a reduction in liver FP-1 may perpetuate hepatic iron retention.	Iron	32-36	solute carrier family 40 member 1	Homo sapiens	103-107
18469261-12	2008	Increased hepcidin formation in iron-overloaded NAFLD patients, however, results in decreased duodenal FP-1 expression, whereas a reduction in liver FP-1 may perpetuate hepatic iron retention.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	10-18
18469261-12	2008	Increased hepcidin formation in iron-overloaded NAFLD patients, however, results in decreased duodenal FP-1 expression, whereas a reduction in liver FP-1 may perpetuate hepatic iron retention.	Iron	177-181	solute carrier family 40 member 1	Homo sapiens	149-153
18727423-1	2008	The review summarizes the results of the state-of-the-art studies of hemochromatosis (HC): iron-regulatory genes (HFE, HJV, HAMP, TFR2, SLC40A1) have been discovered; the HC types caused by mutations in these genes (types 1, 2, 3, and 4 in the OMIM register) have been identified; the inflammation anemia (IA) mediator - the polypeptide hepatic hormone hepcidin that is an important constituent of the natural immunity system - has been found.	Iron	91-95	solute carrier family 40 member 1	Homo sapiens	136-143
18727423-1	2008	The review summarizes the results of the state-of-the-art studies of hemochromatosis (HC): iron-regulatory genes (HFE, HJV, HAMP, TFR2, SLC40A1) have been discovered; the HC types caused by mutations in these genes (types 1, 2, 3, and 4 in the OMIM register) have been identified; the inflammation anemia (IA) mediator - the polypeptide hepatic hormone hepcidin that is an important constituent of the natural immunity system - has been found.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	353-361
18391780-1	2008	PURPOSE OF REVIEW: The peptide hormone hepcidin regulates iron metabolism in response to erythropoietic demand, iron stores and inflammation.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	39-47
18391780-1	2008	PURPOSE OF REVIEW: The peptide hormone hepcidin regulates iron metabolism in response to erythropoietic demand, iron stores and inflammation.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	39-47
18391780-2	2008	Major advances have been made in understanding the regulation of hepcidin production, and consequently the availability of iron for erythropoiesis.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	65-73
18391780-3	2008	RECENT FINDINGS: It is becoming clear that the bone morphogenetic protein (BMP) pathway plays a major role in setting the baseline hepcidin level and, with the assistance of BMP2/4 and hemochromatosis-related proteins hemojuvelin, HFE and transferrin receptor 2, also regulates hepcidin expression in response to iron.	Iron	313-317	bone morphogenetic protein 1	Homo sapiens	47-73
18391780-3	2008	RECENT FINDINGS: It is becoming clear that the bone morphogenetic protein (BMP) pathway plays a major role in setting the baseline hepcidin level and, with the assistance of BMP2/4 and hemochromatosis-related proteins hemojuvelin, HFE and transferrin receptor 2, also regulates hepcidin expression in response to iron.	Iron	313-317	bone morphogenetic protein 1	Homo sapiens	75-78
18048580-1	2008	Dysregulation of brain iron homeostasis is central to early neuropathological events in Alzheimer"s disease (AD), including oxidative stress, inflammatory processes, amyloid deposition, tau phosphorylation, and neuronal cell cycle regulatory failure, leading to apoptosis.	Iron	23-27	microtubule associated protein tau	Homo sapiens	186-189
18421430-2	2008	Mutations in the gene HFE2 cause severe iron overload and are associated with low hepcidin expression.	Iron	40-44	hemojuvelin BMP co-receptor	Homo sapiens	22-26
18425494-0	2008	Iron and inflammation: cross-talk between pathways regulating hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	62-70
22350470-1	2012	Discovered over a decade ago, hephaestin (Heph) has been implicated as a ferroxidase (FOX) vital for intestinal iron absorption.	Iron	112-116	hephaestin	Rattus norvegicus	30-40
22350470-1	2012	Discovered over a decade ago, hephaestin (Heph) has been implicated as a ferroxidase (FOX) vital for intestinal iron absorption.	Iron	112-116	hephaestin	Rattus norvegicus	42-46
22350470-8	2012	Additionally, cytosolic Heph increased upon iron-deprivation but more important, decreased significantly upon copper-deprivation, mimicking the response of membrane-bound Heph.	Iron	44-48	hephaestin	Rattus norvegicus	24-28
22679180-1	2012	BACKGROUND: Hepcidin-25 reduces iron absorption by binding to the intestinal iron transporter ferroportin and causing its degradation.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	12-20
22679180-9	2012	CONCLUSIONS: Our results indicate that in humans, hepcidin-25 exhibits diurnal changes that can be altered by prolonged fasting, which increases hepcidin-25 concentrations approximately 3-fold after 3 days of fasting, possibly owing to a suppression of erythropoiesis that may occur during the fasting state to preserve tissue iron concentrations.	Iron	327-331	hepcidin antimicrobial peptide	Homo sapiens	50-58
21901748-4	2012	The aim of this study was to determine if genetic variations identified in the ceruloplasmin (CP) gene (implicated in iron homeostasis) contribute to OC pathogenesis or susceptibility.	Iron	118-122	ceruloplasmin	Homo sapiens	79-92
21901748-4	2012	The aim of this study was to determine if genetic variations identified in the ceruloplasmin (CP) gene (implicated in iron homeostasis) contribute to OC pathogenesis or susceptibility.	Iron	118-122	ceruloplasmin	Homo sapiens	94-96
22392047-3	2012	Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
22392047-12	2012	Furthermore, serum hepcidin levels were negatively correlated with serum iron levels (R = -0.412, p = 0.002), which were positively correlated with hemoglobin levels (R = 0.210, p = 0.045).	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	19-27
22392047-14	2012	CONCLUSIONS: Inappropriately raised hepcidin levels impair iron metabolism and are associated with decreased hemoglobin levels in KD patients.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	36-44
22705624-2	2012	It was later demonstrated that hepcidin is the long sought hormone that regulates iron homeostasis in mammals.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	31-39
22931678-1	2012	Hepcidin can regulate cell irons" efflux transport.	Iron	27-32	hepcidin antimicrobial peptide	Homo sapiens	0-8
22611157-2	2012	It is mediated by excessive production of the iron-regulatory peptide hepcidin, but the signaling pathway responsible for hepcidin up-regulation in the inflammatory context is still not understood completely.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	70-78
22678361-3	2012	Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18.	Iron	69-73	cytosolic iron-sulfur assembly component 3	Mus musculus	105-109
22768976-1	2012	Recently identified protein hepcidin synthesized in the liver, is thought to be a key regulator for iron homeostasis and is induced by infection and inflammation.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	28-36
22270611-6	2012	Expression of CsTrx1 as determined by quantitative real-time reverse transcriptase PCR was highest in liver and upregulated in time-dependent manners by bacterial infection and by exposure to iron, copper, and hydrogen peroxide.	Iron	192-196	thioredoxin	Cynoglossus semilaevis	14-20
22288465-9	2012	CONCLUSIONS:   These findings suggest that nigral iron deposition, correlating with decreased serum ceruloplasmin levels, is a risk factor in Parkinson"s disease across multiple motor phenotypic expressions.	Iron	50-54	ceruloplasmin	Homo sapiens	100-113
22683637-3	2012	In the present study, we found that iron depletion also induces the transcription of CTR2.	Iron	36-40	low-affinity Cu transporter	Saccharomyces cerevisiae S288C	85-89
22683637-4	2012	The upregulation of CTR2 induced by iron depletion was abrogated by the genetic deletion of either Mac1p or iron-sensing transcription factor Aft1p.	Iron	36-40	low-affinity Cu transporter	Saccharomyces cerevisiae S288C	20-24
22581044-4	2012	Interestingly, on the basis of the presence of a putative iron responsive element in the 5"-UTR, it has been suggested that there is a possible iron-dependent translational control of human alpha-synuclein mRNA.	Iron	58-62	synuclein alpha	Homo sapiens	190-205
22581044-4	2012	Interestingly, on the basis of the presence of a putative iron responsive element in the 5"-UTR, it has been suggested that there is a possible iron-dependent translational control of human alpha-synuclein mRNA.	Iron	144-148	synuclein alpha	Homo sapiens	190-205
22581044-5	2012	Considering the similarity between the sequences present in human alpha-synuclein mRNA and the ferritin iron responsive element, we postulated that iron deficiency would decrease the translation of alpha-synuclein mRNA.	Iron	104-108	synuclein alpha	Homo sapiens	198-213
22581044-6	2012	Here we used HEK293 cells treated with iron chelator deferoxamine or ferric ammonium citrate to verify the possible iron-dependent translational control of human alpha-synuclein biosynthesis.	Iron	39-43	synuclein alpha	Homo sapiens	162-177
22581044-6	2012	Here we used HEK293 cells treated with iron chelator deferoxamine or ferric ammonium citrate to verify the possible iron-dependent translational control of human alpha-synuclein biosynthesis.	Iron	116-120	synuclein alpha	Homo sapiens	162-177
22581044-8	2012	Our data demonstrate that human alpha-synuclein expression is regulated by iron mainly at the translational level.	Iron	75-79	synuclein alpha	Homo sapiens	32-47
22581044-9	2012	This result not only supports a role for iron in the translational control of alpha-synuclein expression, but also suggests that iron chelation may be a valid approach to control alpha-synuclein levels in the brain.	Iron	41-45	synuclein alpha	Homo sapiens	78-93
22581044-9	2012	This result not only supports a role for iron in the translational control of alpha-synuclein expression, but also suggests that iron chelation may be a valid approach to control alpha-synuclein levels in the brain.	Iron	129-133	synuclein alpha	Homo sapiens	179-194
22496243-0	2012	Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism.	Iron	63-65	solute carrier family 46 member 1	Homo sapiens	0-22
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	33-37	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	227-231
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	33-37	PAX interacting protein 1	Homo sapiens	327-331
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	43-45	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	227-231
22556412-4	2012	Here, we found that the bivalent iron ion (Fe(2+), ferrous) suppressed CSR, leading to decreased number of switched B cells, decreased postrecombination Imu-C(H) transcripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterations in critical CSR factors, such as AID, 14-3-3gamma, or PTIP, or in general germline I(H)-S-C(H) transcription.	Iron	43-45	PAX interacting protein 1	Homo sapiens	327-331
22633452-7	2012	Cytosolic iron could modulate the association between PCBP2 and Dicer, as well as the multimerization of PCBP2 and its ability to bind to miRNA precursors, which can alter the processing of miRNA precursors.	Iron	10-14	dicer 1, ribonuclease III	Homo sapiens	64-69
22449175-0	2012	Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression.	Iron	41-45	bone morphogenetic protein 6	Mus musculus	109-137
22449175-1	2012	The BMP/SMAD signalling pathway plays an important role in iron homeostasis, regulating hepcidin expression in response to body iron levels.	Iron	59-63	SMAD family member 1	Mus musculus	8-12
22449175-1	2012	The BMP/SMAD signalling pathway plays an important role in iron homeostasis, regulating hepcidin expression in response to body iron levels.	Iron	128-132	SMAD family member 1	Mus musculus	8-12
18424595-10	2008	We concluded that ferritin-iron is efficiently released from the ferritin molecule during cooking and at gastric pH and that it should be absorbed as efficiently as all other nonheme iron in food.	Iron	27-31	ferritin-1, chloroplastic	Glycine max	18-26
22570273-0	2012	Iron overload potentiates diet-induced hypercholesterolemia and reduces liver PPAR-alpha expression in hamsters.	Iron	0-4	peroxisome proliferator activated receptor alpha	Homo sapiens	78-88
18424595-10	2008	We concluded that ferritin-iron is efficiently released from the ferritin molecule during cooking and at gastric pH and that it should be absorbed as efficiently as all other nonheme iron in food.	Iron	27-31	ferritin-1, chloroplastic	Glycine max	65-73
18424595-10	2008	We concluded that ferritin-iron is efficiently released from the ferritin molecule during cooking and at gastric pH and that it should be absorbed as efficiently as all other nonheme iron in food.	Iron	183-187	ferritin-1, chloroplastic	Glycine max	18-26
22284565-0	2012	Hepcidin concentrations in serum and urine correlate with iron homeostasis in preterm infants.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
21136867-4	2008	Differentially expressed proteins in alpha-synuclein(A30P)-transgenic mice point to alterations in mitochondrial function, actin dynamics, iron transport, and vesicle exocytosis, thus partially resembling findings in PD patients.	Iron	139-143	synuclein, alpha	Mus musculus	37-52
18646536-0	2008	[Effect of iron status of pregnant women on ferroportin 1 expression in third-trimester placenta].	Iron	11-15	solute carrier family 40 member 1	Homo sapiens	44-57
18255115-6	2008	Using two iron chelators (desferrioxamine and deferiprone) and siRNA targeting the lysosomal iron-binding protease lactoferrin, we further demonstrated that both lysosomal iron content and lactoferrin were required for caspase-3 activation and apoptosis-like cell death.	Iron	93-97	lactotransferrin	Rattus norvegicus	115-126
18384687-1	2008	BACKGROUND: Repulsive guidance molecule c (RGMc or hemojuvelin), a glycosylphosphatidylinositol-linked glycoprotein expressed in liver and striated muscle, plays a central role in systemic iron balance.	Iron	189-193	hemojuvelin BMP co-receptor	Homo sapiens	12-41
18384687-1	2008	BACKGROUND: Repulsive guidance molecule c (RGMc or hemojuvelin), a glycosylphosphatidylinositol-linked glycoprotein expressed in liver and striated muscle, plays a central role in systemic iron balance.	Iron	189-193	hemojuvelin BMP co-receptor	Homo sapiens	43-47
18384687-1	2008	BACKGROUND: Repulsive guidance molecule c (RGMc or hemojuvelin), a glycosylphosphatidylinositol-linked glycoprotein expressed in liver and striated muscle, plays a central role in systemic iron balance.	Iron	189-193	hemojuvelin BMP co-receptor	Homo sapiens	51-62
18384687-7	2008	Iron loading reduces release of RGMc from the cell membrane, and diminishes accumulation of the 40 kDa species in cell culture medium.	Iron	0-4	hemojuvelin BMP co-receptor	Homo sapiens	32-36
18419598-2	2008	Divalent metal transporter 1 (DMT1) is also a key transporter of iron under physiological conditions.	Iron	65-69	solute carrier family 11 member 2	Homo sapiens	0-28
18419598-2	2008	Divalent metal transporter 1 (DMT1) is also a key transporter of iron under physiological conditions.	Iron	65-69	solute carrier family 11 member 2	Homo sapiens	30-34
18272225-5	2008	These results were used to calculate the pH dependent speciation, the overall formation constant logbeta(110) (31.4) and pM value (18.3) for H(6)L with iron(III).	Iron	152-156	H6 family homeobox 2	Homo sapiens	141-146
18272225-6	2008	The ability of H(6)L to deliver the essential nutrient iron to living cells is determined through growth promotion assays using various bacterial strains.	Iron	55-59	H6 family homeobox 2	Homo sapiens	15-20
22284565-1	2012	OBJECTIVES: To evaluate whether hepcidin concentrations in serum (Hep((S))) and urine (Hep((U))) correlate with iron metabolism, erythropoiesis, and inflammation in preterm infants.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	32-40
22284565-3	2012	The concentration of the mature, 25 amino-acid form of hepcidin was determined by enzyme-linked immunosorbent assay in serum, urine, blood counts, reticulocytes, and iron measurements.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	55-63
22284565-10	2012	CONCLUSION: In sick preterm infants, iron status, erythropoiesis, anemia, and inflammation correlated with the mature 25 amino-acid form of hepcidin.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	140-148
22950017-0	2012	Human mitochondrial ferritin improves respiratory function in yeast mutants deficient in iron-sulfur cluster biogenesis, but is not a functional homologue of yeast frataxin.	Iron	89-93	ferritin mitochondrial	Homo sapiens	6-28
22950017-1	2012	We overexpressed human mitochondrial ferritin in frataxin-deficient yeast cells (Deltayfh1), but also in another mutant affected in [Fe-S] assembly (Deltaggc1).	Iron	133-137	ferritin mitochondrial	Homo sapiens	23-45
22950017-5	2012	Overexpression of mitochondrial ferritin in [Fe-S] mutants resulted in the appearance of a small pool of high-spin ferrous iron in the mitochondria, which was probably responsible for the improvement of heme synthesis and of the respiratory function in these mutants.	Iron	45-49	ferritin mitochondrial	Homo sapiens	18-40
22950017-5	2012	Overexpression of mitochondrial ferritin in [Fe-S] mutants resulted in the appearance of a small pool of high-spin ferrous iron in the mitochondria, which was probably responsible for the improvement of heme synthesis and of the respiratory function in these mutants.	Iron	123-127	ferritin mitochondrial	Homo sapiens	18-40
22628316-1	2012	The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in this way iron plasma levels.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	98-106
22313374-0	2012	The homozygous mutation G75R in the human SLC11A2 gene leads to microcytic anaemia and iron overload.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	42-49
18356317-2	2008	Soybean ferritin (SBFn), a large, stable protein nanocage around a mineral with hundreds of iron and oxygen atoms, is a source of nutritional iron with an unknown mechanism for intestinal absorption.	Iron	92-96	ferritin-1, chloroplastic	Glycine max	8-16
18356317-2	2008	Soybean ferritin (SBFn), a large, stable protein nanocage around a mineral with hundreds of iron and oxygen atoms, is a source of nutritional iron with an unknown mechanism for intestinal absorption.	Iron	142-146	ferritin-1, chloroplastic	Glycine max	8-16
22419665-0	2012	Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis.	Iron	99-103	endothelial PAS domain protein 1	Mus musculus	0-31
18311908-4	2008	In this study, the structural characteristics of nitrogen-containing compounds, which bind to the iron atom in two CYP isoforms (CYP2C9 and CYP3A4), were investigated.	Iron	98-102	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	129-135
22023453-1	2012	BACKGROUND: Hepcidin plays a central role in iron homeostasis, which is regulated by iron stores, the rate of erythropoiesis, inflammation, and hypoxia.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	12-20
18061239-8	2008	The high efficiency of the composite Fe(0)/Fe3O4 for Cr(VI) reduction is discussed in terms of a special mechanism where an electron is transferred from Fe(0) to magnetite to reduce Fe(oct)3+ to Fe(oct)2+, which is active for Cr(VI) reduction.	Iron	37-42	POU class 5 homeobox 1	Homo sapiens	182-190
22023453-1	2012	BACKGROUND: Hepcidin plays a central role in iron homeostasis, which is regulated by iron stores, the rate of erythropoiesis, inflammation, and hypoxia.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	12-20
17965061-10	2008	Upon its release, hepcidin initially targets macrophage iron recycling.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	18-26
17965061-12	2008	We believe the fact that macrophages respond more acutely to a hepcidin challenge is fully consistent with their central role in maintaining body iron homeostasis.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	63-71
22023453-5	2012	RESULTS: Hepcidin was elevated significantly with increased iron storage in patients at onset of AL when erythropoiesis was depressed by blast cells, then decreased significantly with AL remission, while soluble transferrin receptor (sTfR) concentration was elevated.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	9-17
22023453-8	2012	CONCLUSIONS: Hepcidin production was regulated by iron stores, inflammation and erythropoietic activity in AL patients.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	13-21
22227182-1	2012	BACKGROUNDS: Hepcidin modulates the de novo absorption of iron from the duodenum and the recycling of iron released from the reticuloendothelial system.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	13-21
18380006-3	2008	Here we present a short overview of the results obtained on dynamical properties of myoglobin and homologous hemoproteins, where the photosensitive heme-Fe--ligand bond has allowed transient intermediates to be studied by different flash photolysis methods coupled to Laue X-ray diffraction, thus highlighting some of the dynamical events that characterize diffusion of a diatomic ligand to/from the heme in model hemoproteins.	Iron	153-155	myoglobin	Homo sapiens	84-93
22227182-1	2012	BACKGROUNDS: Hepcidin modulates the de novo absorption of iron from the duodenum and the recycling of iron released from the reticuloendothelial system.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	13-21
18297518-3	2008	Recent discoveries have led to the identification of hepcidin as a key regulator of iron metabolism and to the association of non-transferrin bound iron moieties, such as labile plasma iron, with the end organ damage in iron overload states.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	53-61
22278021-6	2012	IL-10-mediated protection and subsequent renal repair were dependent on the presence of iron and lipocalin-2, since the administration of a neutralizing antibody for lipocalin-2 or administration of IL-10 macrophages pretreated with the iron chelating agent deferoxamine abrogated IL-10-mediated protective effects.	Iron	237-241	interleukin 10	Rattus norvegicus	199-204
22278021-6	2012	IL-10-mediated protection and subsequent renal repair were dependent on the presence of iron and lipocalin-2, since the administration of a neutralizing antibody for lipocalin-2 or administration of IL-10 macrophages pretreated with the iron chelating agent deferoxamine abrogated IL-10-mediated protective effects.	Iron	237-241	interleukin 10	Rattus norvegicus	199-204
18088336-6	2008	The Arabidopsis myb72 knockout mutant was more sensitive to excess Zn or iron (Fe) deficiency than wild type, while Arabidopsis transformants overexpressing bHLH100 showed increased tolerance to high Zn and nickel (Ni) compared to wild-type plants, confirming their role in metal homeostasis in Arabidopsis.	Iron	73-77	myb domain protein 72	Arabidopsis thaliana	16-21
22642995-0	2012	[Malaria: is there a role for the iron-hepcidin axis?	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	39-47
18088336-6	2008	The Arabidopsis myb72 knockout mutant was more sensitive to excess Zn or iron (Fe) deficiency than wild type, while Arabidopsis transformants overexpressing bHLH100 showed increased tolerance to high Zn and nickel (Ni) compared to wild-type plants, confirming their role in metal homeostasis in Arabidopsis.	Iron	79-81	myb domain protein 72	Arabidopsis thaliana	16-21
18160403-7	2008	We have designed a quantitative assay system sensitive enough to detect differences between FTL and FTH iron regulatory elements (IREs) that a standard electrophoretic mobility shift assay does not.	Iron	104-108	ferritin heavy chain 1	Homo sapiens	100-103
18160403-9	2008	These results provide evidence that FTL and FTH subunits respond independently to cellular iron concentrations and underscore the importance of evaluating FTL and FTH IREs separately.	Iron	91-95	ferritin heavy chain 1	Homo sapiens	44-47
22294697-6	2012	Gene expression analysis revealed that loss of Abcb6 results in up-regulation of compensatory porphyrin and iron pathways, associated with elevated protoporphyrin IX (PPIX).	Iron	108-112	ATP-binding cassette, sub-family B (MDR/TAP), member 6	Mus musculus	47-52
17965133-1	2008	Human ceruloplasmin (CP) is a multicopper oxidase essential for normal iron homeostasis.	Iron	71-75	ceruloplasmin	Homo sapiens	6-19
22297204-9	2012	The results indicated high correspondence between most selected cortical, subcortical, and CSF-filled spaces; correspondence was lowest in the globus pallidus, a region rich in iron, which in turn has a considerable field-dependent effect on signal intensity.	Iron	177-181	colony stimulating factor 2	Homo sapiens	91-94
17965133-1	2008	Human ceruloplasmin (CP) is a multicopper oxidase essential for normal iron homeostasis.	Iron	71-75	ceruloplasmin	Homo sapiens	21-23
18073346-0	2008	Autocrine formation of hepcidin induces iron retention in human monocytes.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	23-31
22404347-0	2012	Genetic polymorphisms in bovine transferrin receptor 2 (TFR2) and solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) genes and their association with beef iron content.	Iron	92-96	solute carrier family 40 member 1	Bos taurus	131-138
18073346-1	2008	Hepcidin, a master regulator of iron homeostasis, is produced in small amounts by inflammatory monocytes/macrophages.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
18073346-3	2008	We questioned whether monocyte-derived hepcidin exerts autocrine regulation toward cellular iron metabolism.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	39-47
18073346-5	2008	In ACD patients, monocyte hepcidin mRNA levels were significantly correlated to serum IL-6 concentrations, and increased monocyte hepcidin mRNA levels were associated with decreased expression of the iron exporter ferroportin and iron retention in these cells.	Iron	200-204	hepcidin antimicrobial peptide	Homo sapiens	130-138
18073346-5	2008	In ACD patients, monocyte hepcidin mRNA levels were significantly correlated to serum IL-6 concentrations, and increased monocyte hepcidin mRNA levels were associated with decreased expression of the iron exporter ferroportin and iron retention in these cells.	Iron	230-234	hepcidin antimicrobial peptide	Homo sapiens	130-138
18073346-9	2008	Our results suggest that ferroportin expression in inflammatory monocytes is negatively affected by autocrine formation of hepcidin, thus contributing to iron sequestration within monocytes as found in ACD.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	123-131
22404347-0	2012	Genetic polymorphisms in bovine transferrin receptor 2 (TFR2) and solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) genes and their association with beef iron content.	Iron	178-182	solute carrier family 40 member 1	Bos taurus	131-138
18094142-1	2008	Transferrin receptor 2 (TfR2), a homologue of transferrin receptor 1 (TfR1), is a key molecule involved in the regulation of iron homeostasis.	Iron	125-129	transferrin receptor 2	Homo sapiens	0-22
22404347-3	2012	We hypothesized that genetic polymorphisms in transferrin receptor 2 (TFR2) and solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) could influence skeletal muscle iron content.	Iron	106-110	solute carrier family 40 member 1	Bos taurus	145-152
18094142-1	2008	Transferrin receptor 2 (TfR2), a homologue of transferrin receptor 1 (TfR1), is a key molecule involved in the regulation of iron homeostasis.	Iron	125-129	transferrin receptor 2	Homo sapiens	24-28
18094142-2	2008	Mutations in TfR2 result in iron overload with similar features to HFE-associated hereditary hemochromatosis.	Iron	28-32	transferrin receptor 2	Homo sapiens	13-17
22404347-11	2012	Moreover, SNPs identified in SLC40A1, rs134388440, rs136347850 and rs137555693 might be useful markers for the selection of Angus cattle for altered iron content.	Iron	149-153	solute carrier family 40 member 1	Bos taurus	29-36
18094142-3	2008	The precise role of TfR2 in iron metabolism and the functional consequences of disease-causing mutations have not been fully determined.	Iron	28-32	transferrin receptor 2	Homo sapiens	20-24
22198321-3	2012	There is also evidence showing that a series of genes with important functions in iron metabolism, including transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1), are regulated by HIF-1alpha in response to hypoxia in extra-neural organs or cells.	Iron	82-86	solute carrier family 11 member 2	Homo sapiens	141-169
18160053-3	2008	Mitochondrial ferritin is another major iron-binding protein, abundant in the testis and in sideroblasts from patients with sideroblastic anemia.	Iron	40-44	ferritin mitochondrial	Homo sapiens	0-22
22198321-3	2012	There is also evidence showing that a series of genes with important functions in iron metabolism, including transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1), are regulated by HIF-1alpha in response to hypoxia in extra-neural organs or cells.	Iron	82-86	solute carrier family 11 member 2	Homo sapiens	171-175
18309275-1	2008	Soybean seed ferritin is essential for human iron supplementation and iron deficiency anemia prevention because it contains abundant bioavailable iron and is frequently consumed in the human diet.	Iron	45-49	ferritin-1, chloroplastic	Glycine max	13-21
18309275-1	2008	Soybean seed ferritin is essential for human iron supplementation and iron deficiency anemia prevention because it contains abundant bioavailable iron and is frequently consumed in the human diet.	Iron	70-74	ferritin-1, chloroplastic	Glycine max	13-21
22357659-1	2012	BACKGROUND: We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis.	Iron	47-51	solute carrier family 40 member 1	Homo sapiens	106-113
18309275-7	2008	The purified ferritin complex synthesized in E. coli demonstrated some reported features of its native counterpart from soybean seed, including an apparent molecular weight, multimeric assembly, and iron uptake activity.	Iron	199-203	ferritin-1, chloroplastic	Glycine max	13-21
22357659-5	2012	CONCLUSIONS: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence of an interaction between dietary iron and SLC40A1.	Iron	164-168	solute carrier family 40 member 1	Homo sapiens	173-180
18175002-6	2008	A novel C2-symmetric bis-pentamethylazaferrocene could be synthesised by an iron catalysed oxidative coupling of the enatioenriched C-2 lithio derivative and in the presence of a PhMe-Et2O solvent mixture proceeded in 97% ee.	Iron	76-80	complement C2	Homo sapiens	132-135
22297252-1	2012	Hepcidin is an iron-regulatory hepatic peptide hormone encoded by the HAMP gene that downregulates iron export from enterocytes and macrophages into the blood plasma.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
18223212-10	2008	Iron loading OE33 and SEG-1 cells caused increased cellular proliferation, which was associated with increased H-ferritin and decreased transferrin receptor 1 and DMT1 expression.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	163-167
22297252-1	2012	Hepcidin is an iron-regulatory hepatic peptide hormone encoded by the HAMP gene that downregulates iron export from enterocytes and macrophages into the blood plasma.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	70-74
22297252-1	2012	Hepcidin is an iron-regulatory hepatic peptide hormone encoded by the HAMP gene that downregulates iron export from enterocytes and macrophages into the blood plasma.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	0-8
22297252-1	2012	Hepcidin is an iron-regulatory hepatic peptide hormone encoded by the HAMP gene that downregulates iron export from enterocytes and macrophages into the blood plasma.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	70-74
18024960-0	2008	An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine.	Iron	3-7	Ferritin	Caenorhabditis elegans	32-37
22297252-6	2012	These results indicate that the p.R75X mutation causes iron overload by impairing the hepcidin system.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	86-94
18024960-0	2008	An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine.	Iron	51-55	Ferritin	Caenorhabditis elegans	32-37
18024960-2	2008	Caenorhabditis elegans express two ferritins, FTN-1 and FTN-2, which are transcriptionally regulated by iron.	Iron	104-108	Ferritin	Caenorhabditis elegans	46-51
18024960-3	2008	To identify the cis-acting sequences and proteins required for iron-dependent regulation of ftn-1 and ftn-2 expression, we generated transcriptional GFP reporters corresponding to 5 "-upstream sequences of the ftn-1 and ftn-2 genes.	Iron	63-67	Ferritin	Caenorhabditis elegans	92-97
18024960-3	2008	To identify the cis-acting sequences and proteins required for iron-dependent regulation of ftn-1 and ftn-2 expression, we generated transcriptional GFP reporters corresponding to 5 "-upstream sequences of the ftn-1 and ftn-2 genes.	Iron	63-67	Ferritin	Caenorhabditis elegans	210-215
18024960-4	2008	We identified a conserved 63-bp sequence, the iron-dependent element (IDE), that is required for iron-dependent regulation of a ftn-1 GFP reporter in intestine.	Iron	46-50	Ferritin	Caenorhabditis elegans	128-133
18024960-4	2008	We identified a conserved 63-bp sequence, the iron-dependent element (IDE), that is required for iron-dependent regulation of a ftn-1 GFP reporter in intestine.	Iron	97-101	Ferritin	Caenorhabditis elegans	128-133
18024960-10	2008	These data demonstrate that the activation of ftn-1 and ftn-2 transcription by iron requires ELT-2 and that the IDE functions as an iron-dependent enhancer in intestine.	Iron	79-83	Ferritin	Caenorhabditis elegans	46-51
18712630-4	2008	The regulatory protein hepcidin has a central role in iron homeostasis in these disorders.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	23-31
18289069-3	2008	The precise underlying mechanisms for HO-1-based protection are not yet completely understood, but appear to involve the protective effects of HO-1 by-products, carbon monoxide (CO), biliverdin/bilirubin and free iron.	Iron	213-217	heme oxygenase 1	Homo sapiens	38-42
18289070-1	2008	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme to generate carbon monoxide, biliverdin and free iron.	Iron	107-111	heme oxygenase 1	Homo sapiens	0-16
18289070-1	2008	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme to generate carbon monoxide, biliverdin and free iron.	Iron	107-111	heme oxygenase 1	Homo sapiens	18-22
18289070-4	2008	However, experimental observations indicate that the extent of HO-1 induction may be critical because excessive heme degradation may result in toxic levels of CO, bilirubin and, more importantly, iron.	Iron	196-200	heme oxygenase 1	Homo sapiens	63-67
18289074-1	2008	Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme which catalyzes group heme into carbon monoxide, iron and bilirubin.	Iron	110-114	heme oxygenase 1	Homo sapiens	0-16
18289074-1	2008	Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme which catalyzes group heme into carbon monoxide, iron and bilirubin.	Iron	110-114	heme oxygenase 1	Homo sapiens	18-22
19074074-2	2008	In doing so, hepcidin can control both the total body iron by modulating intestinal iron absorption as well as promote iron available for erythropoiesis by affecting the efficiency with which macrophages recycle iron from effete red blood cells.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	13-21
19074074-3	2008	This review focuses on the systemic and cellular physiology of hepcidin regulation in relation to iron stores, erythropoiesis, inflammation, and hypoxia and how hepcidin regulation and dysregulation contributes to normal iron homeostasis and iron metabolism disorders.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	63-71
18691669-0	2008	Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.	Iron	142-146	melanotransferrin	Homo sapiens	66-69
18691669-0	2008	Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.	Iron	142-146	melanotransferrin	Homo sapiens	163-166
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	70-74	melanotransferrin	Homo sapiens	0-17
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	70-74	melanotransferrin	Homo sapiens	19-22
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	76-78	melanotransferrin	Homo sapiens	0-17
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	76-78	melanotransferrin	Homo sapiens	19-22
18691669-2	2008	Although MTf has a high-affinity Fe-binding site that is practically identical to that of serum Tf, the protein does not play an essential role in Fe homeostasis and its precise molecular function remains unclear.	Iron	33-35	melanotransferrin	Homo sapiens	9-12
18691669-3	2008	A Zn(II)-binding motif, distinct from the Fe-binding site, has been proposed in human MTf based on computer modelling studies.	Iron	42-44	melanotransferrin	Homo sapiens	86-89
18691669-6	2008	Initially, the binding of Fe to MTf was examined using 6M urea gel electrophoresis.	Iron	26-28	melanotransferrin	Homo sapiens	32-35
18691669-10	2008	The ability of MTf to bind Zn(II) was also investigated using CD which demonstrated that the single high-affinity Fe-binding site was distinct from a potential Zn(II)-binding site.	Iron	114-116	melanotransferrin	Homo sapiens	15-18
18306987-3	2008	It has been reported that the enhanced erythropoiesis associated with erythropoietin therapy increases intestinal iron absorption, but the molecular mechanisms underlying are unknown.	Iron	114-118	erythropoietin	Rattus norvegicus	70-84
17900698-4	2008	The structure of [Fe(tach-6-Mepyr)](ClO4)2 implies steric effects of 6-Me groups push donor Npy"s away so one Fe-Npy bond is substantially longer at 2.380(3)A vs. 2.228(3)A for the others, and Fe(II) in the high-spin-state.	Iron	18-20	neuropeptide Y	Homo sapiens	92-95
17900698-4	2008	The structure of [Fe(tach-6-Mepyr)](ClO4)2 implies steric effects of 6-Me groups push donor Npy"s away so one Fe-Npy bond is substantially longer at 2.380(3)A vs. 2.228(3)A for the others, and Fe(II) in the high-spin-state.	Iron	18-20	neuropeptide Y	Homo sapiens	113-116
18304682-1	2008	The cross-talk which has taken place in recent years between clinicians and scientists has resulted in a greater understanding of iron metabolism with the discovery of new iron-related genes including the hepcidin gene which plays a critical role in regulating systemic iron homeostasis.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	205-213
18304682-1	2008	The cross-talk which has taken place in recent years between clinicians and scientists has resulted in a greater understanding of iron metabolism with the discovery of new iron-related genes including the hepcidin gene which plays a critical role in regulating systemic iron homeostasis.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	205-213
18304682-1	2008	The cross-talk which has taken place in recent years between clinicians and scientists has resulted in a greater understanding of iron metabolism with the discovery of new iron-related genes including the hepcidin gene which plays a critical role in regulating systemic iron homeostasis.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	205-213
17766053-3	2008	IL-6 controls systemic iron homeostasis through hepcidin, which is produced mainly by hepatocytes.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	48-56
17766053-7	2008	When hepcidin is abundant, hepatocytes sequester iron, and this inhibits sporozoite development in liver-stage malaria infection.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	5-13
17804247-9	2008	The iron particles within these flexuous oligomers can be defined in the presence of ammonium molybdate, but they are more readily demonstrated if the frataxin is spread across holes in the presence of trehalose alone.	Iron	4-8	frataxin	Rattus norvegicus	151-159
18941633-8	2008	Biochemical analysis revealed that the iron-binding and releasing properties of rhLF were identical to that of native hLF.	Iron	39-43	HLF transcription factor, PAR bZIP family member	Homo sapiens	81-84
19107209-1	2008	BACKGROUND: Hepcidin, a key regulator of iron homeostasis, is increased in response to inflammation and some infections, but the in vivo role of hepcidin, particularly in children with iron deficiency anemia (IDA) is unclear.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	12-20
19189526-2	2008	Hepcidin, a peptide hormone produced by the liver as pro-hepcidin, has recently emerged as a central mediator of iron metabolism.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	0-8
19189526-2	2008	Hepcidin, a peptide hormone produced by the liver as pro-hepcidin, has recently emerged as a central mediator of iron metabolism.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	57-65
19189526-3	2008	Hepcidin regulates intestinal iron absorption, macrophage iron release, and the placental passage of iron.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
19189526-3	2008	Hepcidin regulates intestinal iron absorption, macrophage iron release, and the placental passage of iron.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
19189526-3	2008	Hepcidin regulates intestinal iron absorption, macrophage iron release, and the placental passage of iron.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
17954932-9	2007	The results suggest that Saccharomyces cerevisiae Dap1 stimulates a P450-catalyzed step in sterol synthesis via a distinct localization from its homologues in Schizosaccharomyces pombe and mammals and that this function regulates iron metabolism.	Iron	230-234	Dap1p	Saccharomyces cerevisiae S288C	50-54
18040029-10	2007	This effect can be reversed with the iron chelator deferoxamine, which results in hypoxia-inducible factor 1alpha stabilization and increased tissue survival.	Iron	37-41	hypoxia inducible factor 1, alpha subunit	Mus musculus	82-113
17884229-2	2007	A second version of the receptor (hTfR2) also mediates Tf-dependent iron import.	Iron	68-72	transferrin receptor 2	Homo sapiens	34-39
22301927-0	2012	Iron metabolism in patients with anorexia nervosa: elevated serum hepcidin concentrations in the absence of inflammation.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	66-74
17963253-2	2007	Despite mechanisms to maintain iron homeostasis, harmful iron accumulation can occur in patients with hereditary defects of regulatory proteins, such as hepcidin, or with transfusion-dependent anemias, such as thalassemia and myelodysplastic syndromes.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	153-161
22301935-1	2012	BACKGROUND: Transmembrane protease serine 6 (TMPRSS6) regulates iron homeostasis by inhibiting the expression of hepcidin.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	113-121
17822372-1	2007	Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to biologically active products: carbon monoxide (CO), biliverdin, and ferrous iron.	Iron	127-139	heme oxygenase 1	Homo sapiens	0-16
22320915-1	2012	As the main iron storage site in the body and the main source of the iron-regulatory hormone, hepcidin, the liver plays a pivotal role in iron homeostasis.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	94-102
17822372-1	2007	Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to biologically active products: carbon monoxide (CO), biliverdin, and ferrous iron.	Iron	127-139	heme oxygenase 1	Homo sapiens	18-22
17887916-3	2007	Physiologic heme degradation is catalyzed by two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding carbon monoxide, iron, and biliverdin, an immediate precursor to bilirubin.	Iron	148-152	heme oxygenase 1	Homo sapiens	88-104
17887916-3	2007	Physiologic heme degradation is catalyzed by two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding carbon monoxide, iron, and biliverdin, an immediate precursor to bilirubin.	Iron	148-152	heme oxygenase 1	Homo sapiens	106-110
22033148-2	2012	Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	61-69
17919067-2	2007	The inducible form of these enzymes is heme oxygenase-1 (HO-1), which is the rate-limiting enzyme that can degrade heme into equimolar quantities of carbon monoxide (CO), biliverdin, and free iron.	Iron	192-196	heme oxygenase 1	Homo sapiens	39-55
17919067-2	2007	The inducible form of these enzymes is heme oxygenase-1 (HO-1), which is the rate-limiting enzyme that can degrade heme into equimolar quantities of carbon monoxide (CO), biliverdin, and free iron.	Iron	192-196	heme oxygenase 1	Homo sapiens	57-61
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	128-132	doublesex and mab-3 related transcription factor 1	Homo sapiens	150-154
22066515-6	2012	Blocking glutathione biosynthesis in wild-type plants by a specific inhibitor of GSH1, buthionine sulfoximine, resulted in loss of Fe-mediated Zn tolerance, which provides further evidence that glutathione plays an essential role in Fe-mediated Zn tolerance.	Iron	131-133	glutamate-cysteine ligase	Arabidopsis thaliana	81-85
17637479-1	2007	BACKGROUND/AIMS: Aceruloplasminemia is an inherited iron overload disorder caused by a mutation in the ceruloplasmin gene and characterized by iron accumulation in both the liver and brain.	Iron	52-56	ceruloplasmin	Homo sapiens	18-31
22066515-6	2012	Blocking glutathione biosynthesis in wild-type plants by a specific inhibitor of GSH1, buthionine sulfoximine, resulted in loss of Fe-mediated Zn tolerance, which provides further evidence that glutathione plays an essential role in Fe-mediated Zn tolerance.	Iron	233-235	glutamate-cysteine ligase	Arabidopsis thaliana	81-85
22066515-7	2012	Two glutathione-deficient mutant alleles of GSH1, pad2-1 and cad2-1, which contain 22% and 39%, respectively, of the wild-type glutathione level, revealed that a minimal glutathione level between 22 and 39% of the wild-type level is required for Fe-mediated Zn tolerance.	Iron	246-248	glutamate-cysteine ligase	Arabidopsis thaliana	44-48
17899439-6	2007	An interesting consequence of the presence of soluble Fe(+2) was the formation of Prussian Blue, Fe(4)[Fe(CN)(6)](3), which has been suggested as a possible reservoir of HCN in the initial prebiotic conditions on the Earth.	Iron	54-56	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	170-173
22309771-3	2012	We recently demonstrated that the yeast homologues of human Glrx3 and the yeast BolA-like protein Fra2 form [2Fe-2S]-bridged heterodimers that play a key role in signaling intracellular iron availability.	Iron	186-190	glutaredoxin 3	Homo sapiens	60-65
22228627-0	2012	Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
17948991-4	2007	Reaction of 4 with 1 equiv of Ag(PPh3)OTf gives the mononuclear chelate complex [Ag(OTf)PPh3{Fe(C5H4PR)2-kappaP,kappaP}] (11), whereas treatment with 2 equiv of AuCl(SMe2) produces the dinuclear gold complex [Au(Cl){Fe(C5H4PR)2-kappaP,kappaP}Au(Cl)] (12).	Iron	93-95	protein phosphatase 4 catalytic subunit	Homo sapiens	33-37
22228627-8	2012	We conclude that under conditions of competing signals (anemia, iron deficiency, and infection), hepcidin powerfully controls use of dietary iron.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	97-105
17991645-0	2007	Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus.	Iron	85-89	heme oxygenase 1	Homo sapiens	35-51
22228627-9	2012	We suggest that low-cost point-of-care hepcidin assays would aid iron supplementation programs in the developing world.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	39-47
17991645-3	2007	Heme oxygenase (HO) 1 expression is increased when intracellular iron increases.	Iron	65-69	heme oxygenase 1	Homo sapiens	0-21
22178061-2	2012	Importantly, ceruloplasmin has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin on cellular iron efflux.	Iron	50-54	ceruloplasmin	Homo sapiens	13-26
17453351-9	2007	Iron when co-administered with MiADMSA restored blood ALAD activity.	Iron	0-4	aminolevulinate, delta-, dehydratase	Mus musculus	54-58
22178061-2	2012	Importantly, ceruloplasmin has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin on cellular iron efflux.	Iron	133-137	ceruloplasmin	Homo sapiens	13-26
22178061-8	2012	In macrophages, increased expression levels and co-localization of ferroportin and GPI-ceruloplasmin in cell surface lipid rafts were observed after iron treatment.	Iron	149-153	ceruloplasmin	Homo sapiens	87-100
22178061-9	2012	Such iron upregulation of ceruloplasmin was not observed in HepG2.	Iron	5-9	ceruloplasmin	Homo sapiens	26-39
17951471-0	2007	Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells.	Iron	39-43	leptin	Homo sapiens	0-6
22178061-12	2012	In macrophages, GPI-ceruloplasmin and ferroportin likely interact in lipid rafts to export iron from cells.	Iron	91-95	ceruloplasmin	Homo sapiens	20-33
17951471-0	2007	Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	63-71
17951471-2	2007	We speculated that the adipokine leptin might play a role in regulating iron metabolism in the overweight population because it shares a number of common biological features with IL-6, a major factor in the development of the anemia of chronic disease via its stimulatory actions on the production and release of the iron regulatory hormone hepcidin.	Iron	72-76	leptin	Homo sapiens	33-39
22178061-13	2012	Precise knowledge about ceruloplasmin isoforms expression and function in various cell types will help to clarify the role of ceruloplasmin in many diseases related to iron metabolism, inflammation and oxidative biology.	Iron	168-172	ceruloplasmin	Homo sapiens	24-37
17951471-2	2007	We speculated that the adipokine leptin might play a role in regulating iron metabolism in the overweight population because it shares a number of common biological features with IL-6, a major factor in the development of the anemia of chronic disease via its stimulatory actions on the production and release of the iron regulatory hormone hepcidin.	Iron	317-321	leptin	Homo sapiens	33-39
17951471-10	2007	As a consequence, the increased production of leptin in overweight individuals might be a major contributor to the aberrant iron status observed in these population groups.	Iron	124-128	leptin	Homo sapiens	46-52
22178061-13	2012	Precise knowledge about ceruloplasmin isoforms expression and function in various cell types will help to clarify the role of ceruloplasmin in many diseases related to iron metabolism, inflammation and oxidative biology.	Iron	168-172	ceruloplasmin	Homo sapiens	126-139
26596605-1	2012	A number of popular density functionals are calibrated against high-resolution EPR data for low spin iron-nitrosyls present in nitric oxide bound myoglobin.	Iron	101-105	myoglobin	Homo sapiens	146-155
17473933-2	2007	Regulation of iron absorption is controlled by hepcidin and probably by the crypt program.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	47-55
17473933-3	2007	Hepcidin is a humoral mediator of iron absorption that interacts with the basolateral transporter, ferroportin.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
17473933-4	2007	High levels of hepcidin reduce iron absorption by targeting ferroportin to lysosomes for destruction.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	15-23
17473933-5	2007	It is also proposed that ferroportin is expressed on the apical membrane and coordinates with ferroportin-hepcidin derived from the basal surface to modulate the uptake phase of iron absorption.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	106-114
22320725-8	2012	The results show that MP2 overestimates  E(c)  for atoms heavier than Fe.	Iron	70-72	tryptase pseudogene 1	Homo sapiens	22-25
17473933-7	2007	Under most circumstances, intestinal iron absorption is controlled at multiple levels that lead to hepcidin/ferroportin modulation of the enterocyte labile iron pool (LIP).	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	99-107
17473933-7	2007	Under most circumstances, intestinal iron absorption is controlled at multiple levels that lead to hepcidin/ferroportin modulation of the enterocyte labile iron pool (LIP).	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	99-107
22068601-6	2012	Iron treatment beginning at P7 restored IGF signaling, increased neurogenesis, and normalized all parameters by the end of rapid hippocampal differentiation (P30).	Iron	0-4	insulin-like growth factor 1	Rattus norvegicus	40-43
17510944-2	2007	Animal models with mutation in (DMT1) divalent metal transporter 1 gene, an important brain iron transporter, demonstrate a similar iron deficiency profile as found in RLS brain.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	32-36
22068601-7	2012	Expression of the neuron-specific synaptogenesis marker, disc-large homolog 4 (PSD95), increased more rapidly than the glia-specific myelination marker, myelin basic protein, following iron treatment, suggesting a more robust response to iron therapy in IGF-I-dependent neurons than IGF-II-dependent glia.	Iron	185-189	insulin-like growth factor 1	Rattus norvegicus	254-259
22068601-9	2012	Early postnatal iron treatment of gestational iron deficiency reactivates the IGF system and promotes neurogenesis and differentiation in the hippocampus during a critical developmental period.	Iron	16-20	insulin-like growth factor 1	Rattus norvegicus	78-81
17978060-2	2007	Hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
21413014-0	2012	Hemin, an iron-binding porphyrin, inhibits HIF-1alpha induction through its binding with heat shock protein 90.	Iron	10-14	heat shock protein 90 alpha family class A member 1	Homo sapiens	89-110
17768112-1	2007	Hepcidin is the key regulator of systemic iron homeostasis.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
17768112-2	2007	We describe the modulation of hepcidin production induced by plasma transfusions in a patient with congenital hypotransferrinemia that offers a unique model in which to study the mechanism of hepcidin regulation by iron and erythropoiesis.	Iron	215-219	hepcidin antimicrobial peptide	Homo sapiens	30-38
22104192-6	2012	Hepcidin acts by binding to the iron exporter ferroportin and inducing its degradation.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
17768112-2	2007	We describe the modulation of hepcidin production induced by plasma transfusions in a patient with congenital hypotransferrinemia that offers a unique model in which to study the mechanism of hepcidin regulation by iron and erythropoiesis.	Iron	215-219	hepcidin antimicrobial peptide	Homo sapiens	192-200
17768112-4	2007	Time-course of urinary hepcidin and serum transferrin concentration suggests that hepcidin production is regulated by the combination of marrow iron requirements and iron supply by transferrin.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	82-90
17768112-4	2007	Time-course of urinary hepcidin and serum transferrin concentration suggests that hepcidin production is regulated by the combination of marrow iron requirements and iron supply by transferrin.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	82-90
22104192-7	2012	When hepcidin levels are low, ferroportin expression in cells is sustained leading to export of intracellular iron.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	5-13
22130801-1	2012	Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through the suppression of the iron regulatory hormone hepcidin.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	137-145
17620357-1	2007	Solute carrier family 11 member a1 (Slc11a1; formerly Nramp1) encodes a late endosomal/lysosomal protein/divalent cation transporter that regulates iron homeostasis in macrophages.	Iron	148-152	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-34
22130801-4	2012	Without prior iron loading, a rapid reduction in plasma hepcidin was observed that was almost complete by the second day at altitude.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	56-64
17853512-5	2007	One notable exception was the slightly lower expression level of ceruloplasmin (ferroxidase) in male CSF (0.81), a copper containing protein that catalyzes the conversion of ferrous iron to ferric iron with antioxidant properties.	Iron	174-186	ceruloplasmin	Homo sapiens	65-78
22130801-6	2012	Prior iron loading delayed the decrease in hepcidin until after the transferrin saturation, but not the ferritin concentration, had normalized.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	43-51
22052915-0	2012	Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.	Iron	96-100	activating transcription factor 1	Homo sapiens	0-33
18232299-4	2007	The current study showed that Hepcidin may be a key factor to control intestinal iron absorbing and regulates iron homeostasis, and may be an important regulating hormone of iron metabolism.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	30-38
18232299-4	2007	The current study showed that Hepcidin may be a key factor to control intestinal iron absorbing and regulates iron homeostasis, and may be an important regulating hormone of iron metabolism.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	30-38
18232299-4	2007	The current study showed that Hepcidin may be a key factor to control intestinal iron absorbing and regulates iron homeostasis, and may be an important regulating hormone of iron metabolism.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	30-38
17540841-5	2007	Paradoxically, in previous studies in primary hepatocytes and cell lines, hepcidin response to iron or iron transferrin was not observed.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	74-82
22398782-1	2012	BACKGROUND: Hemojuvelin (HJV) has recently emerged as one of a number of significant regulators of iron homeostasis and hepcidin expression.	Iron	99-103	hemojuvelin BMP co-receptor	Homo sapiens	12-23
17540841-10	2007	Fresh primary hepatocytes constitute a sufficient system for the regulation of hepcidin by physiologic iron stimuli and will greatly facilitate studies of major disorders of iron homeostasis.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	79-87
17452986-0	2007	The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.	Iron	78-82	growth factor receptor bound protein 2-associated protein 2	Mus musculus	47-50
22398782-1	2012	BACKGROUND: Hemojuvelin (HJV) has recently emerged as one of a number of significant regulators of iron homeostasis and hepcidin expression.	Iron	99-103	hemojuvelin BMP co-receptor	Homo sapiens	25-28
23092063-2	2012	Since its discovery many studies confirmed role of liver hormone hepcidin as key regulator of iron metabolism and pointed out liver as the central organ of system iron homeostasis.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	65-73
17714865-0	2007	Copper- and iron-induced differential fibril formation in alpha-synuclein: TEM study.	Iron	12-16	synuclein alpha	Homo sapiens	58-73
23092063-10	2012	We also discuss mechanisms underlying systemic and cellular iron regulation with emphasis on central regulatory hormone hepcidin.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	120-128
22652713-4	2012	As any agent that lowers hepcidin may be an effective strategy to normalize iron homeostasis and overcome renal anemia, testosterone deficiency should be considered in this patient group.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	25-33
17766440-7	2007	The biophysical properties of mitoNEET suggest that it may participate in a redox-sensitive signaling and/or in Fe-S cluster transfer.	Iron	112-116	CDGSH iron sulfur domain 1	Homo sapiens	30-38
23177986-1	2012	Divalent metal-ion transporter-1 (DMT1) is a widely expressed, iron-preferring membrane transport protein.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	0-32
17540589-4	2007	A 25-amino-acid peptide hepcidin is up-regulated by iron and by inflammation, and it inhibits iron absorption and traps iron in macrophages by binding to and causing degradation of the iron transport protein ferroportin.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	24-32
17540589-4	2007	A 25-amino-acid peptide hepcidin is up-regulated by iron and by inflammation, and it inhibits iron absorption and traps iron in macrophages by binding to and causing degradation of the iron transport protein ferroportin.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	24-32
17540589-4	2007	A 25-amino-acid peptide hepcidin is up-regulated by iron and by inflammation, and it inhibits iron absorption and traps iron in macrophages by binding to and causing degradation of the iron transport protein ferroportin.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	24-32
23177986-1	2012	Divalent metal-ion transporter-1 (DMT1) is a widely expressed, iron-preferring membrane transport protein.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	34-38
23177986-2	2012	Animal models establish that DMT1 plays indispensable roles in intestinal nonheme-iron absorption and iron acquisition by erythroid precursor cells.	Iron	82-86	solute carrier family 11 member 2	Homo sapiens	29-33
17617114-0	2007	Does hepcidin expression have a role in iron-related hepatic injury in patients with non-alcoholic steatohepatitis?	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	5-13
23177986-2	2012	Animal models establish that DMT1 plays indispensable roles in intestinal nonheme-iron absorption and iron acquisition by erythroid precursor cells.	Iron	102-106	solute carrier family 11 member 2	Homo sapiens	29-33
23177986-9	2012	An iron-responsive element (IRE) in the mRNA 3"-untranslated region permits the regulation of some isoforms by iron status, and additional mechanisms by which DMT1 is regulated are emerging.	Iron	3-7	solute carrier family 11 member 2	Homo sapiens	159-163
17721544-3	2007	Accumulation of iron in the absence of blood transfusions may result from inappropriate suppression of the iron-regulating peptide hepcidin by an erythropoietic mechanism.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	131-139
23177986-11	2012	The principal or only intestinal nonheme-iron transporter, DMT1 is a validated therapeutic target in hereditary hemochromatosis (HHC) and other iron-overload disorders.	Iron	41-45	solute carrier family 11 member 2	Homo sapiens	59-63
17721544-3	2007	Accumulation of iron in the absence of blood transfusions may result from inappropriate suppression of the iron-regulating peptide hepcidin by an erythropoietic mechanism.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	131-139
22754573-5	2012	This additional free-iron has the capacity to generate reactive oxygen species, promote the aggregation of alpha-synuclein protein, and exacerbate or even cause neurodegeneration.	Iron	21-25	synuclein alpha	Homo sapiens	107-122
17521857-2	2007	The p.Cys282Tyr mutation of the HFE gene leads to an abnormal reduction in hepatic expression of hepcidin, a protein that appears to control the release of iron from enterocytes and macrophages towards plasma.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	97-105
17521857-3	2007	Abnormally low hepcidin levels promote an increase in the bioavailability of plasma iron, characterized by elevated transferrin saturation and the appearance of non transferrin bound iron.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	15-23
17521857-3	2007	Abnormally low hepcidin levels promote an increase in the bioavailability of plasma iron, characterized by elevated transferrin saturation and the appearance of non transferrin bound iron.	Iron	183-187	hepcidin antimicrobial peptide	Homo sapiens	15-23
17521857-6	2007	Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP).	Iron	99-103	hemojuvelin BMP co-receptor	Homo sapiens	221-232
17521857-6	2007	Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP).	Iron	99-103	hemojuvelin BMP co-receptor	Homo sapiens	234-237
17521857-6	2007	Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP).	Iron	99-103	transferrin receptor 2	Homo sapiens	240-262
17521857-6	2007	Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP).	Iron	99-103	transferrin receptor 2	Homo sapiens	264-268
17521857-6	2007	Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP).	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	275-283
17521857-6	2007	Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP).	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	285-289
17540536-6	2007	They are due to hyperabsorption of dietary iron and are linked to a deficit of hepcidin, the principal iron regulator in the body.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	79-87
17540536-7	2007	Ferroportin disease is a special dominantly inherited clinical form of iron overload due to mutations of the SLC40A1 gene.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	109-116
23144745-1	2012	The recent discovery of hepcidin, the key iron regulatory hormone, has changed our view of iron metabolism, which in turn is long known to be linked with insulin resistant states, including type 2 diabetes mellitus and the Metabolic Syndrome (MetS).	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	24-32
17661447-1	2007	Human ceruloplasmin (CP) is a multicopper oxidase essential for normal iron homeostasis.	Iron	71-75	ceruloplasmin	Homo sapiens	6-19
17661447-1	2007	Human ceruloplasmin (CP) is a multicopper oxidase essential for normal iron homeostasis.	Iron	71-75	ceruloplasmin	Homo sapiens	21-23
23144745-1	2012	The recent discovery of hepcidin, the key iron regulatory hormone, has changed our view of iron metabolism, which in turn is long known to be linked with insulin resistant states, including type 2 diabetes mellitus and the Metabolic Syndrome (MetS).	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	24-32
23144745-8	2012	Overall, these data indicate that the fundamental iron regulatory feedback is preserved in MetS, i.e. that hepcidin tends to progressively increase in response to the increase of iron stores.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	107-115
17559793-2	2007	Adhfe1 is unique in that the sequence of its encoded protein places it among the iron-activated ADHs.	Iron	81-85	alcohol dehydrogenase, iron containing, 1	Mus musculus	0-6
23144745-8	2012	Overall, these data indicate that the fundamental iron regulatory feedback is preserved in MetS, i.e. that hepcidin tends to progressively increase in response to the increase of iron stores.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	107-115
23029472-8	2012	The preferential binding of HJV for BMP6 is consistent with the functional role of HJV and BMP6 in regulating systemic iron homeostasis.	Iron	119-123	hemojuvelin BMP co-receptor	Homo sapiens	28-31
23029472-8	2012	The preferential binding of HJV for BMP6 is consistent with the functional role of HJV and BMP6 in regulating systemic iron homeostasis.	Iron	119-123	hemojuvelin BMP co-receptor	Homo sapiens	83-86
17268421-2	2007	It seems to be managed by the key mediator of iron kinetics, hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	61-69
22880029-4	2012	In this study, employing a setup for single-channel electrophysiology, we found that addition of iron-induced alpha-synuclein oligomers resulted in quantized and stepwise increases in bilayer conductance indicating insertion of distinct transmembrane pores.	Iron	97-101	synuclein alpha	Homo sapiens	110-125
17640859-12	2007	Both carriers of the -72C&gt;T Hepcidin mutation had beta-thalassemia trait, moderate iron overload, and liver cirrhosis.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	31-39
22880029-9	2012	Our findings indicate that iron-induced alpha-synuclein oligomers can form a uniform and distinct pore species with characteristic electrophysiological properties.	Iron	27-31	synuclein alpha	Homo sapiens	40-55
22808058-1	2012	Hepcidin-25, the bioactive form of hepcidin, is a key regulator of iron homeostasis as it induces internalization and degradation of ferroportin, a cellular iron exporter on enterocytes, macrophages and hepatocytes.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
17538022-5	2007	Phosphorylation of S210 and S224 in Aft1p, which is not iron dependent, and the iron-induced intermolecular interaction of Aft1p are both essential for its recognition by Msn5p.	Iron	80-84	karyopherin MSN5	Saccharomyces cerevisiae S288C	171-176
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	41-45	karyopherin MSN5	Saccharomyces cerevisiae S288C	175-180
22808058-1	2012	Hepcidin-25, the bioactive form of hepcidin, is a key regulator of iron homeostasis as it induces internalization and degradation of ferroportin, a cellular iron exporter on enterocytes, macrophages and hepatocytes.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	35-43
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	219-223	karyopherin MSN5	Saccharomyces cerevisiae S288C	175-180
22808058-1	2012	Hepcidin-25, the bioactive form of hepcidin, is a key regulator of iron homeostasis as it induces internalization and degradation of ferroportin, a cellular iron exporter on enterocytes, macrophages and hepatocytes.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	0-8
22808058-1	2012	Hepcidin-25, the bioactive form of hepcidin, is a key regulator of iron homeostasis as it induces internalization and degradation of ferroportin, a cellular iron exporter on enterocytes, macrophages and hepatocytes.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	35-43
22808058-10	2012	In conclusion, in the currently studied cohort of chronic HD patients, hepcidin-25 was a marker for iron stores and erythropoiesis and was associated with inflammation.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	71-79
17553781-8	2007	Furthermore, both CTR2 and FRE6 mRNA levels are regulated by iron availability.	Iron	61-65	low-affinity Cu transporter	Saccharomyces cerevisiae S288C	18-22
22808058-13	2012	These results suggest that hepcidin is involved in the pathophysiological pathway of renal anemia and iron availability in these patients, but challenges its function as a clinical parameter for ESA resistance.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	27-35
22616008-0	2012	The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.	Iron	87-89	Yap5p	Saccharomyces cerevisiae S288C	16-20
17502383-4	2007	The activation of TLR4 by heme is exquisitely strict, requiring its coordinated iron and the vinyl groups of the porphyrin ring.	Iron	80-84	toll like receptor 4	Homo sapiens	18-22
17593032-0	2007	Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
22616008-4	2012	Microarray analyses were also performed to identify new targets of the iron responsive factor Yap5.	Iron	71-75	Yap5p	Saccharomyces cerevisiae S288C	94-98
17593032-1	2007	Hepcidin is an iron-regulatory protein that is upregulated in response to increased iron or inflammatory stimuli.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
22586470-0	2012	Hepcidin expression in iron overload diseases is variably modulated by circulating factors.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
17593032-2	2007	Hepcidin reduces serum iron and induces iron sequestration in the reticuloendothelial macrophages - the hallmark of anaemia of inflammation.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
17593032-2	2007	Hepcidin reduces serum iron and induces iron sequestration in the reticuloendothelial macrophages - the hallmark of anaemia of inflammation.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
17593032-11	2007	We hypothesise that hepcidin upregulation by p53 is part of a defence mechanism against cancer, through iron deprivation.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	20-28
22509377-1	2012	BACKGROUND: Iron-refractory iron deficiency anaemia (IRIDA) is a rare disorder which was linked to mutations in two genes (SLC11A2 and TMPRSS6).	Iron	12-16	solute carrier family 11 member 2	Homo sapiens	123-130
17486601-1	2007	An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte.	Iron	3-7	solute carrier family 40 member 1	Homo sapiens	17-30
22509377-10	2012	One individual exhibiting the joint SLC11A2/TMPRSS6 profile of the anaemic son had iron and ferritin levels lying below the 5(th) percentile of the population"s iron and ferritin level distribution.	Iron	83-87	solute carrier family 11 member 2	Homo sapiens	36-43
17486601-1	2007	An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte.	Iron	3-7	solute carrier family 40 member 1	Homo sapiens	32-37
17486601-1	2007	An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte.	Iron	193-197	solute carrier family 40 member 1	Homo sapiens	17-30
22509377-10	2012	One individual exhibiting the joint SLC11A2/TMPRSS6 profile of the anaemic son had iron and ferritin levels lying below the 5(th) percentile of the population"s iron and ferritin level distribution.	Iron	161-165	solute carrier family 11 member 2	Homo sapiens	36-43
17486601-1	2007	An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte.	Iron	193-197	solute carrier family 40 member 1	Homo sapiens	32-37
17486601-6	2007	In stably transfected human intestinal absorptive cells expressing human FPN-1 modified by the addition of GFP at the C-terminus, we show that FPN-1-GFP is located on the basolateral membrane and it is associated with Heph suggesting the possibility that FPN-1 might associate and interact with Heph in the process of iron exit across the basolateral membrane of intestinal absorptive cell.	Iron	318-322	solute carrier family 40 member 1	Homo sapiens	143-148
17486601-6	2007	In stably transfected human intestinal absorptive cells expressing human FPN-1 modified by the addition of GFP at the C-terminus, we show that FPN-1-GFP is located on the basolateral membrane and it is associated with Heph suggesting the possibility that FPN-1 might associate and interact with Heph in the process of iron exit across the basolateral membrane of intestinal absorptive cell.	Iron	318-322	solute carrier family 40 member 1	Homo sapiens	143-148
22088162-2	2011	We have exploited the low phytic acid 1-1 (lpa1-1) mutant of maize to generate transgenic plants with up-to 70 mug/g seed iron through the endosperm-specific overexpression of soybean ferritin, resulting in more than 2-fold improvement in iron bioavailability.	Iron	122-126	inositol-3-phosphate synthase	Zea mays	43-49
22088162-2	2011	We have exploited the low phytic acid 1-1 (lpa1-1) mutant of maize to generate transgenic plants with up-to 70 mug/g seed iron through the endosperm-specific overexpression of soybean ferritin, resulting in more than 2-fold improvement in iron bioavailability.	Iron	239-243	inositol-3-phosphate synthase	Zea mays	43-49
17607365-2	2007	By decreasing cell surface expression of the iron exporter ferroportin, hepcidin decreases iron absorption from the intestine and iron release from reticuloendothelial stores.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	72-80
17607365-2	2007	By decreasing cell surface expression of the iron exporter ferroportin, hepcidin decreases iron absorption from the intestine and iron release from reticuloendothelial stores.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	72-80
22088162-4	2011	Gene expression studies reveal a large induction of the YS1 transporter in leaves and severe repression of an iron acquisition gene DMAS1 in roots, suggesting significant alterations in the iron homeostatic mechanisms in transgenic lpa1-1.	Iron	110-114	inositol-3-phosphate synthase	Zea mays	232-238
17607365-6	2007	We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction of hepcidin expression in vitro and that administration of HJV.Fc decreases hepcidin expression, increases ferroportin expression, mobilizes splenic iron stores, and increases serum iron levels in vivo.	Iron	231-235	hemojuvelin BMP co-receptor	Homo sapiens	26-37
17607365-6	2007	We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction of hepcidin expression in vitro and that administration of HJV.Fc decreases hepcidin expression, increases ferroportin expression, mobilizes splenic iron stores, and increases serum iron levels in vivo.	Iron	231-235	hemojuvelin BMP co-receptor	Homo sapiens	39-42
22088162-4	2011	Gene expression studies reveal a large induction of the YS1 transporter in leaves and severe repression of an iron acquisition gene DMAS1 in roots, suggesting significant alterations in the iron homeostatic mechanisms in transgenic lpa1-1.	Iron	190-194	inositol-3-phosphate synthase	Zea mays	232-238
17607365-6	2007	We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction of hepcidin expression in vitro and that administration of HJV.Fc decreases hepcidin expression, increases ferroportin expression, mobilizes splenic iron stores, and increases serum iron levels in vivo.	Iron	231-235	hemojuvelin BMP co-receptor	Homo sapiens	141-144
17607365-6	2007	We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction of hepcidin expression in vitro and that administration of HJV.Fc decreases hepcidin expression, increases ferroportin expression, mobilizes splenic iron stores, and increases serum iron levels in vivo.	Iron	264-268	hemojuvelin BMP co-receptor	Homo sapiens	26-37
17607365-6	2007	We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction of hepcidin expression in vitro and that administration of HJV.Fc decreases hepcidin expression, increases ferroportin expression, mobilizes splenic iron stores, and increases serum iron levels in vivo.	Iron	264-268	hemojuvelin BMP co-receptor	Homo sapiens	39-42
17607365-6	2007	We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction of hepcidin expression in vitro and that administration of HJV.Fc decreases hepcidin expression, increases ferroportin expression, mobilizes splenic iron stores, and increases serum iron levels in vivo.	Iron	264-268	hemojuvelin BMP co-receptor	Homo sapiens	141-144
17607365-7	2007	These data support a role for modulators of the BMP signaling pathway in treating diseases of iron overload and anemia of chronic disease.	Iron	94-98	bone morphogenetic protein 1	Homo sapiens	48-51
22088162-5	2011	Furthermore, preliminary tests show that the high-iron lpa1-1 seeds have higher germination rates and seedling vigor when compared to those of the nontransgenic seeds, which may help improve their value to plant breeders.	Iron	50-54	inositol-3-phosphate synthase	Zea mays	55-61
22055522-2	2011	Hepcidin, a peptide marker of clinical disorders linked to iron metabolism, was used as model to demonstrate peptide quantification potentialities of LC-chip coupled to a nanoelectrospray source ion trap mass spectrometer in an aqueous sample.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	0-8
18293685-6	2007	The basic features shared by iron overload disorders associated with mutation in HFE, hepcidine, hemojuvelin, transferring receptor 2, ferroportin gene indicate that they are genetic variation of the same syndrome.	Iron	29-33	hemojuvelin BMP co-receptor	Homo sapiens	97-108
22256677-0	2011	Effect of different iron loads on serum and tissue biochemical parameters and liver hepcidin mRNA abundance of neonatal piglets.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	84-92
17541408-2	2007	Cellular iron export is impaired in mice and humans with aceruloplasminemia, an iron overload disease due to mutations in the ferroxidase ceruloplasmin (Cp).	Iron	9-13	ceruloplasmin	Homo sapiens	58-71
22256677-9	2011	In conclusion, Fe-overload and deficiency would influence Fe-metabolism, serum biochemical indexes, oxidation state and hepcidin mRNA abundance in piglet liver.	Iron	15-17	hepcidin antimicrobial peptide	Homo sapiens	120-128
17311997-0	2007	Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle.	Iron	7-11	myoglobin	Homo sapiens	121-130
22127690-1	2011	OBJECTIVE: To explore the utility of the novel iron indices hepcidin, reticulocyte hemoglobin content (Ret-Hgb), and erythrocyte (red blood cell) hemoglobin content (RBC-Hgb) for detection of iron deficiency in rheumatoid arthritis (RA) patients with anemia and active inflammation and to compare these indices with conventional parameters of iron deficiency.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	60-68
17311997-1	2007	Iron is essential for oxygen transport because it is incorporated in the heme of the oxygen-binding proteins hemoglobin and myoglobin.	Iron	0-4	myoglobin	Homo sapiens	124-133
17311997-2	2007	An interaction between iron homeostasis and oxygen regulation is further suggested during hypoxia, in which hemoglobin and myoglobin syntheses have been reported to increase.	Iron	23-27	myoglobin	Homo sapiens	123-132
17311997-7	2007	Thus, in HA, the elevated iron requirement associated with enhanced erythropoiesis presumably elicits iron mobilization and myoglobin down-modulation, suggesting an altered muscle oxygen homeostasis.	Iron	26-30	myoglobin	Homo sapiens	124-133
17613866-0	2007	Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	133-141
17613866-1	2007	Hypertransfusional (&gt;8 transfusions/year) iron in liver biopsies collected immediately after transfusions in beta-thalassemia and sickle cell disease correlated with increased expression (RNA) for iron regulatory proteins 1 and 2 (3-, 9- to 11-fold) and hepcidin RNA: (5- to 8-fold) (each p &lt;.01), while ferritin H and L RNA remained constant.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	257-265
17613866-4	2007	Increased hepcidin, after correction of anemia by transfusion, likely reflects excess liver iron.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	10-18
17557668-4	2007	Hepcidin is a small protein that regulates the activity of the iron exporting protein ferroportin in the basolateral membrane of duodenal cells and the cell membrane of macrophages and thereby controls serum iron concentration.	Iron	208-212	hepcidin antimicrobial peptide	Homo sapiens	0-8
17557668-5	2007	Plasma hepcidin concentration is elevated in body iron excess and by inflammatory stimuli, and is lowered in erythroid iron demand, hypoxia and most types of hereditary haemochromatosis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	7-15
17557668-5	2007	Plasma hepcidin concentration is elevated in body iron excess and by inflammatory stimuli, and is lowered in erythroid iron demand, hypoxia and most types of hereditary haemochromatosis.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	7-15
17414503-4	2007	RECENT FINDINGS: Recently discovered molecules, for example hepcidin, lactoferrin receptor and heme carrier protein may be important for iron metabolism in children.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	60-68
17561842-0	2007	Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats.	Iron	55-59	hephaestin	Rattus norvegicus	17-27
17561842-5	2007	Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut.	Iron	61-65	hephaestin	Rattus norvegicus	23-33
17561842-5	2007	Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut.	Iron	100-104	hephaestin	Rattus norvegicus	23-33
17135308-0	2007	Heterozygous beta-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C. BACKGROUND: Iron accumulation is a well-known risk factor for the progression of chronic hepatitis C (CHC) to fibrosis.	Iron	61-65	hemoglobin subunit beta	Homo sapiens	13-24
17135308-0	2007	Heterozygous beta-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C. BACKGROUND: Iron accumulation is a well-known risk factor for the progression of chronic hepatitis C (CHC) to fibrosis.	Iron	134-138	hemoglobin subunit beta	Homo sapiens	13-24
17135308-2	2007	AIM: To evaluate the relative role of haemachromatosis (HFE), ferroportin and beta-globin gene mutations in promoting iron accumulation and fibrosis in patients with CHC.	Iron	118-122	hemoglobin subunit beta	Homo sapiens	78-89
17135308-6	2007	Hepatic iron concentration (HIC) and hepatic stainable iron were significantly higher (p&lt;0.05) in patients with CHC carrying beta-globin mutations than in those with HFE mutations or the wild-type alleles.	Iron	8-12	hemoglobin subunit beta	Homo sapiens	128-139
17135308-6	2007	Hepatic iron concentration (HIC) and hepatic stainable iron were significantly higher (p&lt;0.05) in patients with CHC carrying beta-globin mutations than in those with HFE mutations or the wild-type alleles.	Iron	55-59	hemoglobin subunit beta	Homo sapiens	128-139
17135308-7	2007	Multivariate analysis confirmed that the presence of beta-globin mutations was independently associated with both HIC (p = 0.008) and hepatic-stainable iron (odds ratio (OR) 6.11; 95% CI 1.56 to 23.92; p = 0.009).	Iron	152-156	hemoglobin subunit beta	Homo sapiens	53-64
17135308-10	2007	CONCLUSIONS: Heterozygosis for beta-globin mutations is a novel risk factor for both hepatic iron accumulation and the progression to fibrosis in patients with CHC.	Iron	93-97	hemoglobin subunit beta	Homo sapiens	31-42
17488680-2	2007	Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of iron from the diet and the recycling of iron by macrophages.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-8
17488680-2	2007	Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of iron from the diet and the recycling of iron by macrophages.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
17488680-2	2007	Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of iron from the diet and the recycling of iron by macrophages.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
17488680-3	2007	In turn, hepcidin release is increased by iron loading and inhibited by erythropoietic activity.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	9-17
17488680-4	2007	Hepcidin deficiency is the cause of iron overload in most forms of hereditary hemochromatosis.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
17488680-5	2007	We sought to determine hepcidin"s role in the pathogenesis of iron overload in b-thalassemia.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	23-31
17483071-5	2007	After adjustment for potential confounding variables, which included age, sex, number of diseases, renal failure, cancer, gastric ulcer, albumin, and iron concentrations, individuals in the group with higher IGFBP-3 concentrations showed a significantly higher mean hemoglobin concentration than participants in the group with lower IGFBP-3 concentrations (13.4 +/- 1.4 g/dL versus 12.9 +/- 1.9 g/dL, respectively; P=.03).	Iron	150-154	insulin like growth factor binding protein 3	Homo sapiens	208-215
17401378-6	2007	Our data suggest that the Cfd1-Nbp35 complex functions as a novel scaffold for [Fe-S] cluster assembly in the eukaryotic cytosol.	Iron	80-84	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	26-30
17401378-6	2007	Our data suggest that the Cfd1-Nbp35 complex functions as a novel scaffold for [Fe-S] cluster assembly in the eukaryotic cytosol.	Iron	80-84	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	31-36
17417656-2	2007	We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5" untranslated region of the messenger RNA encoding endothelial PAS domain protein-1, EPAS1 (also called hypoxia-inducible factor-2alpha, HIF2alpha).	Iron	51-55	endothelial PAS domain protein 1	Homo sapiens	141-173
17417656-2	2007	We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5" untranslated region of the messenger RNA encoding endothelial PAS domain protein-1, EPAS1 (also called hypoxia-inducible factor-2alpha, HIF2alpha).	Iron	51-55	endothelial PAS domain protein 1	Homo sapiens	175-180
17417656-2	2007	We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5" untranslated region of the messenger RNA encoding endothelial PAS domain protein-1, EPAS1 (also called hypoxia-inducible factor-2alpha, HIF2alpha).	Iron	51-55	endothelial PAS domain protein 1	Homo sapiens	194-225
17417656-2	2007	We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5" untranslated region of the messenger RNA encoding endothelial PAS domain protein-1, EPAS1 (also called hypoxia-inducible factor-2alpha, HIF2alpha).	Iron	51-55	endothelial PAS domain protein 1	Homo sapiens	227-236
17417656-3	2007	Via this IRE, iron regulatory protein binding controls EPAS1 mRNA translation in response to cellular iron availability.	Iron	14-18	endothelial PAS domain protein 1	Homo sapiens	55-60
17417656-3	2007	Via this IRE, iron regulatory protein binding controls EPAS1 mRNA translation in response to cellular iron availability.	Iron	102-106	endothelial PAS domain protein 1	Homo sapiens	55-60
17363110-1	2007	Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	53-61
17363110-7	2007	Hepcidin was regulated by iron in a dose dependent manner: low doses up to 3 microM increased hepcidin expression, high doses of iron (65 microM) revealed a switch-over to down-regulation of hepcidin expression.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	0-8
17363110-7	2007	Hepcidin was regulated by iron in a dose dependent manner: low doses up to 3 microM increased hepcidin expression, high doses of iron (65 microM) revealed a switch-over to down-regulation of hepcidin expression.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	94-102
17363110-7	2007	Hepcidin was regulated by iron in a dose dependent manner: low doses up to 3 microM increased hepcidin expression, high doses of iron (65 microM) revealed a switch-over to down-regulation of hepcidin expression.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	191-199
17363110-7	2007	Hepcidin was regulated by iron in a dose dependent manner: low doses up to 3 microM increased hepcidin expression, high doses of iron (65 microM) revealed a switch-over to down-regulation of hepcidin expression.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	0-8
17363110-7	2007	Hepcidin was regulated by iron in a dose dependent manner: low doses up to 3 microM increased hepcidin expression, high doses of iron (65 microM) revealed a switch-over to down-regulation of hepcidin expression.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	191-199
17363110-8	2007	Regulation of hepcidin in HepG2 and RINm5F cells at mRNA and protein level by these substances indicates its involvement in inflammation and iron metabolism.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	14-22
17274015-0	2007	A PM3/d specific reaction parameterization for iron atom in the hydrogen abstraction catalyzed by soybean lipoxygenase-1.	Iron	47-51	maturation protein PM3	Glycine max	2-5
17274015-1	2007	This paper reports a specific reaction parameter (SRP) PM3/d model for iron that can reproduce the DFT/MM results of the hydrogen abstraction reaction from the C11 position of linoleic acid by the Soybean lipoxygenase-1 enzyme.	Iron	71-75	maturation protein PM3	Glycine max	55-58
17331953-0	2007	Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.	Iron	64-68	hemojuvelin BMP co-receptor	Homo sapiens	28-39
17331953-2	2007	Hepcidin, the central iron regulatory hormone, is secreted from hepatocytes, whereas HFE2 is highly expressed in skeletal muscle and liver.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
17331953-5	2007	In acutely iron-deficient rats with markedly suppressed hepatic hepcidin expression, we detected an early phase increase of serum HJV with no significant change of either HFE2 mRNA or protein levels in gastrocnemius muscle.	Iron	11-15	hemojuvelin BMP co-receptor	Homo sapiens	130-133
17331953-7	2007	In agreement with the observations in iron-deficient rats, HJV shedding in these cell lines was down-regulated by holo-transferrin in a concentration-dependent manner.	Iron	38-42	hemojuvelin BMP co-receptor	Homo sapiens	59-62
17109629-1	2007	DMT1 (divalent metal-ion transporter 1) is a widely expressed metal-ion transporter that is vital for intestinal iron absorption and iron utilization by most cell types throughout the body, including erythroid precursors.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	0-4
17109629-1	2007	DMT1 (divalent metal-ion transporter 1) is a widely expressed metal-ion transporter that is vital for intestinal iron absorption and iron utilization by most cell types throughout the body, including erythroid precursors.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	6-38
17109629-1	2007	DMT1 (divalent metal-ion transporter 1) is a widely expressed metal-ion transporter that is vital for intestinal iron absorption and iron utilization by most cell types throughout the body, including erythroid precursors.	Iron	133-137	solute carrier family 11 member 2	Homo sapiens	0-4
17109629-1	2007	DMT1 (divalent metal-ion transporter 1) is a widely expressed metal-ion transporter that is vital for intestinal iron absorption and iron utilization by most cell types throughout the body, including erythroid precursors.	Iron	133-137	solute carrier family 11 member 2	Homo sapiens	6-38
17337530-7	2007	When supplied with Fe-DMA as a Fe source, transgenic Arabidopsis (Arabidopsis thaliana) plants expressing a cauliflower mosaic virus 35S-ZmYS1 gene construct showed less growth depression than wild-type plants in response to Cd.	Iron	19-21	iron-phytosiderophore transporter yellow stripe 1	Zea mays	137-142
17493330-1	2007	Mitochondrial ferritin (MtF), a new player in iron metabolism, first identified in 2001, is highly homologous to ferritin both structurally and functionally.	Iron	46-50	ferritin mitochondrial	Homo sapiens	0-28
17493330-2	2007	Preliminary studies have suggested that MtF might play very important roles in the regulation of mitochondrial iron homeostasis.	Iron	111-115	ferritin mitochondrial	Homo sapiens	40-43
17493330-4	2007	However, little is known about what roles MtF might play in leukemic cell iron metabolism and cell proliferation.	Iron	74-78	ferritin mitochondrial	Homo sapiens	42-45
17194704-8	2007	The ferric state of the AHSP/alpha-Hb complex shows hexacoordination even at atmospheric pressures, indicating a His-Fe-His binding scheme as previously observed in neuroglobin and cytoglobin.	Iron	117-119	alpha hemoglobin stabilizing protein	Homo sapiens	24-28
17202145-1	2007	Transferrin receptor 2 (TfR2) is a homolog of transferrin receptor 1 (TfR1), the receptor responsible for the uptake of iron-loaded transferrin (holo-Tf) into cells.	Iron	120-124	transferrin receptor 2	Homo sapiens	0-22
17202145-1	2007	Transferrin receptor 2 (TfR2) is a homolog of transferrin receptor 1 (TfR1), the receptor responsible for the uptake of iron-loaded transferrin (holo-Tf) into cells.	Iron	120-124	transferrin receptor 2	Homo sapiens	24-28
17202145-3	2007	Mutations in TfR2 gene cause a rare autosomal recessive form of the iron overload disease, hereditary hemochromatosis.	Iron	68-72	transferrin receptor 2	Homo sapiens	13-17
21989113-8	2011	Hepcidin is detected in biologic fluids as a 25 amino acid isoform, hepcidin-25, and 2 smaller forms, i.e., hepcidin-22 and -20; however, only hepcidin-25 has been shown to participate in the regulation of iron metabolism.	Iron	206-210	hepcidin antimicrobial peptide	Homo sapiens	0-8
22081142-5	2011	Blood-stage parasites stimulate the production of the host iron-regulatory factor hepcidin, which redistributes iron away from hepatocytes, reducing the development of the iron-dependent liver stage.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	82-90
17313717-1	2007	Hepcidin plays a major role in iron homeostasis, but understanding its role has been hampered by the absence of analytical methods for quantification in blood.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
22081142-5	2011	Blood-stage parasites stimulate the production of the host iron-regulatory factor hepcidin, which redistributes iron away from hepatocytes, reducing the development of the iron-dependent liver stage.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	82-90
17032174-1	2007	Cp (ceruloplasmin), a copper containing plasma protein, mainly synthesized in the liver, is known to be functional between the interface of iron and copper metabolism.	Iron	140-144	ceruloplasmin	Homo sapiens	4-17
21465240-1	2011	The heavy chain subunit of ferritin (FHC), a ubiquitous protein best known for its iron-sequestering activity as part of the ferritin complex, has recently been described as a novel inhibitor of signaling through the chemokine receptor CXCR4.	Iron	83-87	low density lipoprotein receptor	Homo sapiens	37-40
17121833-3	2007	Mammalian cells utilize transferrin-dependent mechanisms to acquire iron via transferrin receptors 1 and 2 (TfR1 and TfR2) by receptor-mediated endocytosis.	Iron	68-72	transferrin receptor 2	Homo sapiens	77-106
17121833-3	2007	Mammalian cells utilize transferrin-dependent mechanisms to acquire iron via transferrin receptors 1 and 2 (TfR1 and TfR2) by receptor-mediated endocytosis.	Iron	68-72	transferrin receptor 2	Homo sapiens	117-121
22060282-1	2011	OBJECTIVES: The absorption of commonly used ferrous iron salts from intestinal segments at neutral to slightly alkaline pH is low, mainly because soluble ferrous iron is easily oxidized to poorly soluble ferric iron and ferrous iron but not ferric iron is carried by the divalent metal transporter DMT-1.	Iron	44-56	solute carrier family 11 member 2	Homo sapiens	298-303
16980551-2	2007	HO-1 catalyzes the degradation of heme, a potent oxidant, into biliverdin, iron, and carbon monoxide (CO).	Iron	75-79	heme oxygenase 1	Homo sapiens	0-4
22060282-1	2011	OBJECTIVES: The absorption of commonly used ferrous iron salts from intestinal segments at neutral to slightly alkaline pH is low, mainly because soluble ferrous iron is easily oxidized to poorly soluble ferric iron and ferrous iron but not ferric iron is carried by the divalent metal transporter DMT-1.	Iron	154-166	solute carrier family 11 member 2	Homo sapiens	298-303
22194696-1	2011	Caenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine.	Iron	57-61	Ferritin	Caenorhabditis elegans	23-28
16990612-3	2007	One protein providing such cytoprotective activity is heme oxygenase-1 (HO-1), an enzyme that catalyzes the rate-limiting reaction in heme catabolism (i.e., the oxidative cleavage of b-type heme molecules to yield equimolar quantities of biliverdin IXalpha, carbon monoxide, and iron).	Iron	279-283	heme oxygenase 1	Homo sapiens	54-70
16990612-3	2007	One protein providing such cytoprotective activity is heme oxygenase-1 (HO-1), an enzyme that catalyzes the rate-limiting reaction in heme catabolism (i.e., the oxidative cleavage of b-type heme molecules to yield equimolar quantities of biliverdin IXalpha, carbon monoxide, and iron).	Iron	279-283	heme oxygenase 1	Homo sapiens	72-76
22194696-2	2011	Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown.	Iron	95-99	Ferritin	Caenorhabditis elegans	136-141
17487261-1	2007	Lactoferrin (Lf), an iron-binding multifunctional glycoprotein, is abundantly present in colostrum and milk of different species such as humans, bovines, and mice.	Iron	21-25	lactotransferrin	Bos taurus	0-11
17229910-2	2007	Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
17229910-2	2007	Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	0-8
17229910-2	2007	Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	0-8
22088320-1	2011	Lactoferrin is an iron binding glycoprotein possessing multiple immune modulatory activities, including ability to affect macrophage cytokine production, promote maturation of T- and B-lymphocyte and immature dendritic cells, and enhance the ability of macrophages and dendritic cells to stimulate antigen-specific T-cells.	Iron	18-22	lactotransferrin	Mus musculus	0-11
17229910-3	2007	By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macrophages, and the release of iron from storage in hepatocytes.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	19-27
17229910-3	2007	By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macrophages, and the release of iron from storage in hepatocytes.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	19-27
17229910-3	2007	By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macrophages, and the release of iron from storage in hepatocytes.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	19-27
17229910-4	2007	Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
17229910-4	2007	Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
17229910-4	2007	Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
22525500-10	2011	CONCLUSIONS: HCV NS5A inhibits the transcription of hepcidin mRNA and expression of hepcidin protein, inducing hepatic intracellular iron storage.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	52-60
17229910-4	2007	Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
17229910-4	2007	Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
17229910-5	2007	During inflammation, increased hepcidin concentrations cause iron sequestration in macrophages, resulting in hypoferremia and eventually anemia of inflammation.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	31-39
17229910-6	2007	Hepcidin deficiency plays a central role in most iron overload disorders.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
21926174-0	2011	Leucine biosynthesis regulates cytoplasmic iron-sulfur enzyme biogenesis in an Atm1p-independent manner.	Iron	43-47	ATP binding cassette subfamily B member 7	Homo sapiens	79-84
17430183-11	2007	Lactoferrin acts by induction of apoptosis, inhibition of angiogenesis, modulation of carcinogen metabolising enzymes and perhaps acting as an iron scavenger.	Iron	143-147	lactotransferrin	Rattus norvegicus	0-11
21867695-0	2011	Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by a robust LC-MS/MS method.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	41-49
18086376-0	2007	Modulation of macrophage iron transport by Nramp1 (Slc11a1).	Iron	25-29	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	43-49
18086376-0	2007	Modulation of macrophage iron transport by Nramp1 (Slc11a1).	Iron	25-29	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	51-58
18086376-2	2007	Nramp1 acts as a transporter for protons, iron, and other divalent cations, and Nramp1 functionality is associated with an enhanced activity of pro-inflammatory immune pathways, including the formation of nitric oxide (NO) via transcriptional stimulation of inducible nitric oxide synthase (iNOS) expression.	Iron	42-46	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
21867695-1	2011	BACKGROUND: The measurement of serum hepcidin, a peptide hormone that regulates iron metabolism, is clinically important to the understanding of iron homeostasis in health and disease.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	37-45
21867695-1	2011	BACKGROUND: The measurement of serum hepcidin, a peptide hormone that regulates iron metabolism, is clinically important to the understanding of iron homeostasis in health and disease.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	37-45
21867695-10	2011	CONCLUSIONS: We have developed and validated a new method for measuring hepcidin concentrations in human serum and urine and used it to demonstrate early increases with iron supplement in both urinary and serum levels of hepcidin, which return to baseline levels, except in urine samples from men.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	72-80
21867695-10	2011	CONCLUSIONS: We have developed and validated a new method for measuring hepcidin concentrations in human serum and urine and used it to demonstrate early increases with iron supplement in both urinary and serum levels of hepcidin, which return to baseline levels, except in urine samples from men.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	221-229
22860160-6	2011	In this paper, we sought to map the interactions between the di- and trivalent cations, Cu(II), Pb(II), Fe(II), and Fe(III), and the C-terminal region of alpha-syn encompassing residues 107-140 and to determine how phosphorylation at S129 or Y125 alters the specificity and binding affinity of metals using electrospray ionization-mass spectrometry (ESI-MS) and fluorescence spectroscopy.	Iron	104-106	synuclein alpha	Homo sapiens	154-163
21876117-1	2011	Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	45-53
17346427-6	2007	Finally, we demonstrate that iron chelation is part of the mechanism by which PA and DFX activate GFAT expression.	Iron	29-33	glutamine fructose-6-phosphate transaminase 1	Mus musculus	98-102
17703461-1	2007	We report a 45-year-old woman with iron deficient anemia (IDA) who underwent a collection of allogeneic peripheral blood stem cells (PBSCs) induced by granulocyte-colony stimulating factor (G-CSF) after a rapid improvement of IDA by iron replacement.	Iron	35-39	colony stimulating factor 3	Homo sapiens	151-188
17703461-1	2007	We report a 45-year-old woman with iron deficient anemia (IDA) who underwent a collection of allogeneic peripheral blood stem cells (PBSCs) induced by granulocyte-colony stimulating factor (G-CSF) after a rapid improvement of IDA by iron replacement.	Iron	35-39	colony stimulating factor 3	Homo sapiens	190-195
17969640-1	2007	A kind of Fe-polysilicate polymer, poly-silicic-ferric (PSF) coagulant was prepared by co-polymerization (hydroxylation of mixture of Fe3+ and fresh polysilicic acid (PS)), in which PSF0.5, PSF1 or PSF3 denotes Si/Fe molar ratio of 0.5, 1 or 3, respectively.	Iron	10-12	GINS complex subunit 3	Homo sapiens	198-202
21981036-0	2011	Synthesis and decarbonylation reactions of the triiron phosphinidene complex [Fe3Cp3(mu-H)(mu3-PPh)(CO)4]: easy cleavage and formation of P-H and Fe-Fe bonds.	Iron	78-80	enolase 1	Homo sapiens	95-98
17507875-0	2007	Iron-mediated dismutation of superoxide anion augments antigen-induced allergic inflammation: effect of lactoferrin.	Iron	0-4	lactotransferrin	Mus musculus	104-115
22219776-0	2011	(RS)-Tricarbon-yl(eta-1,3-diacet-oxy-5,5-dimethyl-cyclo-hexa-1,3-diene)iron(0).	Iron	71-75	secreted phosphoprotein 1	Homo sapiens	18-23
17313075-0	2007	[Function of hepcidin in iron metabolism].	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	13-21
17236123-1	2007	It is hypothesized that a homozygous C282Y mutation of the HFE gene prohibits the assembly of the transferrin-receptor 1 (TFR1) with the divalent metal transporter (DMT1) as the main iron update complex in hepatocytes membrane.	Iron	183-187	solute carrier family 11 member 2	Homo sapiens	165-169
21181293-1	2011	Hepcidin plays a key role in regulating iron metabolism by blocking iron efflux from macrophages and enterocytes.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
21181293-1	2011	Hepcidin plays a key role in regulating iron metabolism by blocking iron efflux from macrophages and enterocytes.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
17177551-2	2006	The addition of the type II, iron chelating antioxidants sodium tripolyphosphate (at pH 7.2) or milk mineral (at pH 5.6) negated the effect of added iron, slowing oxidation of myoglobin.	Iron	149-153	myoglobin	Homo sapiens	176-185
21181293-2	2011	Hepcidin is synthesized primarily in the liver, and its expression is increased by iron overload and inflammation.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	0-8
17177551-3	2006	A clear concentration dependence was seen for iron-stimulated myoglobin oxidation, based on both spectral and visual evidence.	Iron	46-50	myoglobin	Homo sapiens	62-71
21848699-0	2011	Hemojuvelin hemochromatosis receiving iron chelation therapy with deferasirox: improvement of liver disease activity, cardiac and hematological function.	Iron	38-42	hemojuvelin BMP co-receptor	Homo sapiens	0-11
17177551-4	2006	Further investigation is needed to determine the possible role for nonheme ferrous iron on myoglobin oxidation in vivo or in meat.	Iron	83-87	myoglobin	Homo sapiens	91-100
17156779-6	2006	mRNA and protein expressions increased in Caco-2 cells transduced with HCP1 adenoviral plasmid, and consequently (55)Fe haem uptake was higher in these cells.	Iron	117-119	solute carrier family 46 member 1	Homo sapiens	71-75
21745449-11	2011	CONCLUSIONS: These observations show that Tfr2 and Hfe are each required for normal signaling of iron status to hepcidin via the Bmp6/Smad1,5,8 pathway.	Iron	97-101	bone morphogenetic protein 6	Mus musculus	129-133
17416047-4	2006	This implicates especially macrophages and enterocytes, ensuring the import of iron into plasma, as well as systemic signals, including hepcidin a peptide mainly produced by hepatocytes and secreted in plasma, which modulates iron leakage from these cells into plasma.	Iron	226-230	hepcidin antimicrobial peptide	Homo sapiens	136-144
17416047-6	2006	The description of new iron metabolism genes, including hepcidin, paves the road for novel diagnostic tools and therapeutic strategies in the field of diseases associated with iron metabolism abnormalities.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	56-64
22099153-3	2011	In this study we analyzed abundances miRNA-125b and miRNA-146a in magnesium-, iron-, gallium, and aluminum-sulfate-stressed human-astroglial (HAG) cells, a structural and immune-responsive brain cell type.	Iron	78-82	microRNA 146a	Homo sapiens	52-62
16886906-4	2006	Analysis of the mouse IRP1 promoter sequence revealed two conserved putative binding sites for transcription factor(s) regulated by NO and/or changes in intracellular iron level: Sp1 (promoter-selective transcription factor 1) and MTF1 (metal transcription factor 1), plus GAS (interferon-gamma-activated sequence), a binding site for STAT (signal transducer and activator of transcription) proteins.	Iron	167-171	trans-acting transcription factor 1	Mus musculus	184-225
16886906-4	2006	Analysis of the mouse IRP1 promoter sequence revealed two conserved putative binding sites for transcription factor(s) regulated by NO and/or changes in intracellular iron level: Sp1 (promoter-selective transcription factor 1) and MTF1 (metal transcription factor 1), plus GAS (interferon-gamma-activated sequence), a binding site for STAT (signal transducer and activator of transcription) proteins.	Iron	167-171	metal response element binding transcription factor 1	Mus musculus	231-235
22099153-4	2011	The combination of iron- plus aluminum-sulfate was found to be significantly synergistic in up-regulating reactive oxygen species (ROS) abundance, NF-kB-DNA binding and miRNA-125b and miRNA-146a expression.	Iron	19-23	microRNA 146a	Homo sapiens	184-194
21768301-2	2011	The peptide hormone hepcidin regulates iron metabolism, and insufficient hepcidin synthesis is responsible for iron overload in minimally transfused patients with this disease.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	20-28
17215883-5	2006	Several isoforms of NRAMP2 (SLC11A2, DMT1, DCT1) are expressed ubiquitously in recycling endosomes or specifically at the apical membrane of epithelial cells in intestine and kidneys, and can contribute to iron overload, whereas mutations impairing NRAMP2 function cause a form of congenital microcytic hypochromic anemia.	Iron	206-210	solute carrier family 11 member 2	Homo sapiens	20-26
17215883-5	2006	Several isoforms of NRAMP2 (SLC11A2, DMT1, DCT1) are expressed ubiquitously in recycling endosomes or specifically at the apical membrane of epithelial cells in intestine and kidneys, and can contribute to iron overload, whereas mutations impairing NRAMP2 function cause a form of congenital microcytic hypochromic anemia.	Iron	206-210	solute carrier family 11 member 2	Homo sapiens	28-35
17215883-5	2006	Several isoforms of NRAMP2 (SLC11A2, DMT1, DCT1) are expressed ubiquitously in recycling endosomes or specifically at the apical membrane of epithelial cells in intestine and kidneys, and can contribute to iron overload, whereas mutations impairing NRAMP2 function cause a form of congenital microcytic hypochromic anemia.	Iron	206-210	solute carrier family 11 member 2	Homo sapiens	37-41
21768301-2	2011	The peptide hormone hepcidin regulates iron metabolism, and insufficient hepcidin synthesis is responsible for iron overload in minimally transfused patients with this disease.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	73-81
17215883-5	2006	Several isoforms of NRAMP2 (SLC11A2, DMT1, DCT1) are expressed ubiquitously in recycling endosomes or specifically at the apical membrane of epithelial cells in intestine and kidneys, and can contribute to iron overload, whereas mutations impairing NRAMP2 function cause a form of congenital microcytic hypochromic anemia.	Iron	206-210	solute carrier family 11 member 2	Homo sapiens	43-47
21963719-0	2011	Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans.	Iron	0-4	corepressor interacting with RBPJ, CIR1	Homo sapiens	61-65
17030577-3	2006	Here, physiological analysis of a napA strain was the approach used to assess the iron-sequestering and stress resistance roles of NapA, its role in preventing oxidative DNA damage, and its importance to mouse colonization.	Iron	82-86	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	34-38
17030577-4	2006	The napA strain was more sensitive to oxidative stress reagents and to oxygen, and it contained fourfold more intracellular free iron and more damaged DNA than the parent strain.	Iron	129-133	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	4-8
17030577-5	2006	Pure, iron-loaded NapA bound to DNA, but native NapA did not, presumably linking iron levels sensed by NapA to DNA damage protection.	Iron	6-10	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	18-22
17030577-5	2006	Pure, iron-loaded NapA bound to DNA, but native NapA did not, presumably linking iron levels sensed by NapA to DNA damage protection.	Iron	81-85	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	18-22
21963719-0	2011	Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans.	Iron	37-41	corepressor interacting with RBPJ, CIR1	Homo sapiens	61-65
21963719-1	2011	The GATA-type, zinc-finger protein Cir1 regulates iron uptake, iron homeostasis and virulence factor expression in the fungal pathogen Cryptococcus neoformans.	Iron	50-54	corepressor interacting with RBPJ, CIR1	Homo sapiens	35-39
21963719-1	2011	The GATA-type, zinc-finger protein Cir1 regulates iron uptake, iron homeostasis and virulence factor expression in the fungal pathogen Cryptococcus neoformans.	Iron	63-67	corepressor interacting with RBPJ, CIR1	Homo sapiens	35-39
17330503-7	2006	IL-1RA concentration was negatively associated with intake of vitamin E and C3 was positively related to intake of Ca and Fe in the subjects with LDL-cholesterol &gt; or = 130 mg/dL.	Iron	122-124	interleukin 1 receptor antagonist	Homo sapiens	0-6
21963719-2	2011	The mechanisms by which Cir1 senses iron availability, although as yet undefined, are important for understanding the proliferation of the fungus in mammalian hosts.	Iron	36-40	corepressor interacting with RBPJ, CIR1	Homo sapiens	24-28
21963719-3	2011	We investigated the influence of iron availability on Cir1 and found that the abundance of the protein decreases upon iron deprivation.	Iron	33-37	corepressor interacting with RBPJ, CIR1	Homo sapiens	54-58
21963719-3	2011	We investigated the influence of iron availability on Cir1 and found that the abundance of the protein decreases upon iron deprivation.	Iron	118-122	corepressor interacting with RBPJ, CIR1	Homo sapiens	54-58
21963719-5	2011	The combined data suggest a post-translational mechanism for the control of Cir1 abundance in response to iron and redox status.	Iron	106-110	corepressor interacting with RBPJ, CIR1	Homo sapiens	76-80
21944046-0	2011	Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes.	Iron	13-17	NFU1 iron-sulfur cluster scaffold	Homo sapiens	48-52
16954050-3	2006	Transcriptional fusions demonstrated that iha transcription is repressed by iron.	Iron	76-80	bifunctional enterobactin receptor/adhesin protein	Escherichia coli	42-45
17185172-0	2006	Differential expression of endogenous ferritin genes and iron homeostasis alteration in transgenic tobacco overexpressing soybean ferritin gene.	Iron	57-61	ferritin-1, chloroplastic	Glycine max	130-138
21944046-0	2011	Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes.	Iron	13-17	bolA family member 3	Homo sapiens	57-62
21919840-3	2011	We have shown recently that iron content is a critical determinant in the antitumour activity of bovine milk lactoferrin (bLF).	Iron	28-32	lactotransferrin	Bos taurus	109-120
16835372-1	2006	Iron homeostasis is maintained through meticulous regulation of circulating hepcidin levels.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	76-84
16835372-2	2006	Hepcidin levels that are inappropriately low or high result in iron overload or iron deficiency, respectively.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
22088544-1	2011	BACKGROUND: Heme oxygenase-1 (HO-1) is an enzyme, which catabolizes heme into carbon monoxide, biliverdin and free iron.	Iron	115-119	heme oxygenase 1	Homo sapiens	12-28
16835372-3	2006	Although hypoxia, erythroid demand, iron, and inflammation are all known to influence hepcidin expression, the mechanisms responsible are not well defined.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	86-94
22088544-1	2011	BACKGROUND: Heme oxygenase-1 (HO-1) is an enzyme, which catabolizes heme into carbon monoxide, biliverdin and free iron.	Iron	115-119	heme oxygenase 1	Homo sapiens	30-34
21785351-5	2011	On the host side, hepcidin, a key regulator of mammalian iron metabolism, has emerged as an important mediator of the cross-talk between iron homeostasis and inflammation.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	18-26
17065470-5	2006	Mice with retinal iron overload resulting from knockout of ceruloplasmin and its homologue hephaestin exhibit retinal degeneration with some features of AMD, including subretinal neovascularization, accumulation of RPE lipofuscin and sub-RPE deposits, and RPE/photoreceptor death.	Iron	18-22	ceruloplasmin	Mus musculus	59-72
17182432-6	2006	Considering the fact that ceruloplasmin is the major ferroxidase essential for iron efflux, iron deposits in the hypoceruloplasminemic patients with Wilson disease are not a complication, but a natural event.	Iron	79-83	ceruloplasmin	Homo sapiens	26-39
21785351-5	2011	On the host side, hepcidin, a key regulator of mammalian iron metabolism, has emerged as an important mediator of the cross-talk between iron homeostasis and inflammation.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	18-26
17182432-6	2006	Considering the fact that ceruloplasmin is the major ferroxidase essential for iron efflux, iron deposits in the hypoceruloplasminemic patients with Wilson disease are not a complication, but a natural event.	Iron	92-96	ceruloplasmin	Homo sapiens	26-39
21785351-6	2011	Hepcidin-dependent changes in iron flux can influence the expression of inflammatory cytokines, and conversely, inflammatory cytokines can induce hepcidin expression and alter iron homeostasis.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
21785351-6	2011	Hepcidin-dependent changes in iron flux can influence the expression of inflammatory cytokines, and conversely, inflammatory cytokines can induce hepcidin expression and alter iron homeostasis.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	0-8
21785351-7	2011	Hepcidin levels have been found to be elevated in some studies of inflammatory bowel disease, while manipulating hepcidin expression in animal models of this condition has beneficial effects on both inflammation and dysregulated iron metabolism.	Iron	229-233	hepcidin antimicrobial peptide	Homo sapiens	113-121
21712541-7	2011	RESULTS: Data revealed that a high level of mitochondrial ferritin reduced reactive oxygen species and Stat5 phosphorylation while promoting mitochondrial iron loading and cytosolic iron starvation.	Iron	155-159	ferritin mitochondrial	Homo sapiens	44-66
17042977-2	2006	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the catabolism of heme into biliverdin, releasing free iron and carbon monoxide.	Iron	110-114	heme oxygenase 1	Homo sapiens	0-16
17042977-2	2006	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the catabolism of heme into biliverdin, releasing free iron and carbon monoxide.	Iron	110-114	heme oxygenase 1	Homo sapiens	18-22
17002471-10	2006	Because BPDS binds Fe2+ but not Fe3+ and because only Fe2+ is transported by DMT-1, the finding that BPDS inhibited uptake from NaFeEDTA suggests that at least some iron dissociates from EDTA and is reduced just as simple inorganic iron at the brush border membrane of the enterocyte.	Iron	165-169	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-82
21712541-7	2011	RESULTS: Data revealed that a high level of mitochondrial ferritin reduced reactive oxygen species and Stat5 phosphorylation while promoting mitochondrial iron loading and cytosolic iron starvation.	Iron	182-186	ferritin mitochondrial	Homo sapiens	44-66
21712541-8	2011	The decline of Stat5 phosphorylation induced a decrease of the level of anti-apoptotic Bcl-xL transcript compared to that in control cells; however, transferrin receptor 1 transcript increased due to the activation of the iron responsive element/iron regulatory protein machinery.	Iron	222-226	signal transducer and activator of transcription 5A	Homo sapiens	15-20
21712541-8	2011	The decline of Stat5 phosphorylation induced a decrease of the level of anti-apoptotic Bcl-xL transcript compared to that in control cells; however, transferrin receptor 1 transcript increased due to the activation of the iron responsive element/iron regulatory protein machinery.	Iron	246-250	signal transducer and activator of transcription 5A	Homo sapiens	15-20
21712541-9	2011	Also, high expression of mitochondrial ferritin increased apoptosis, limited heme synthesis and promoted the formation of Perls-positive granules, identified by electron microscopy as iron granules in mitochondria.	Iron	184-188	ferritin mitochondrial	Homo sapiens	25-47
16757684-0	2006	In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.	Iron	47-51	ferritin mitochondrial	Homo sapiens	92-114
21712541-10	2011	CONCLUSIONS: Our results provide evidence suggesting that Stat5-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin.	Iron	134-138	signal transducer and activator of transcription 5A	Homo sapiens	58-63
16757684-2	2006	Our previous results have shown that MtFt overexpression markedly affects intracellular iron homeostasis in mammalian cells.	Iron	88-92	ferritin mitochondrial	Homo sapiens	37-41
16757684-3	2006	Using tumor xenografts, we examined the effects of MtFt overexpression on tumor iron metabolism and growth.	Iron	80-84	ferritin mitochondrial	Homo sapiens	51-55
21712541-10	2011	CONCLUSIONS: Our results provide evidence suggesting that Stat5-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin.	Iron	134-138	ferritin mitochondrial	Homo sapiens	168-190
16757684-5	2006	Mitochondrial iron deposition in MtFt-expressing tumors was directly observed by transmission electron microscopy.	Iron	14-18	ferritin mitochondrial	Homo sapiens	33-37
21712541-11	2011	The protein interferes with JAK2/STAT5 pathways and with the mechanism of mitochondrial iron accumulation.	Iron	88-92	signal transducer and activator of transcription 5A	Homo sapiens	33-38
16757684-6	2006	A cytosolic iron starvation phenotype in MtFt-expressing tumors was revealed by increased RNA-binding activity of iron regulatory proteins, and concomitantly both an increase in transferrin receptor levels and a decrease in cytosolic ferritin.	Iron	12-16	ferritin mitochondrial	Homo sapiens	41-45
16757684-6	2006	A cytosolic iron starvation phenotype in MtFt-expressing tumors was revealed by increased RNA-binding activity of iron regulatory proteins, and concomitantly both an increase in transferrin receptor levels and a decrease in cytosolic ferritin.	Iron	114-118	ferritin mitochondrial	Homo sapiens	41-45
21901209-1	2011	In healthy subjects, the rate of dietary iron absorption, as well as the amount and distribution of body iron are tightly controlled by hepcidin, the iron regulatory hormone.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	136-144
16757684-9	2006	In conclusion, our study shows that high MtFt levels can significantly affect tumor iron homeostasis by shunting iron into mitochondria; iron scarcity resulted in partially deficient heme and iron-sulfur cluster synthesis.	Iron	84-88	ferritin mitochondrial	Homo sapiens	41-45
16757684-9	2006	In conclusion, our study shows that high MtFt levels can significantly affect tumor iron homeostasis by shunting iron into mitochondria; iron scarcity resulted in partially deficient heme and iron-sulfur cluster synthesis.	Iron	113-117	ferritin mitochondrial	Homo sapiens	41-45
21901209-1	2011	In healthy subjects, the rate of dietary iron absorption, as well as the amount and distribution of body iron are tightly controlled by hepcidin, the iron regulatory hormone.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	136-144
16757684-9	2006	In conclusion, our study shows that high MtFt levels can significantly affect tumor iron homeostasis by shunting iron into mitochondria; iron scarcity resulted in partially deficient heme and iron-sulfur cluster synthesis.	Iron	113-117	ferritin mitochondrial	Homo sapiens	41-45
16757684-9	2006	In conclusion, our study shows that high MtFt levels can significantly affect tumor iron homeostasis by shunting iron into mitochondria; iron scarcity resulted in partially deficient heme and iron-sulfur cluster synthesis.	Iron	113-117	ferritin mitochondrial	Homo sapiens	41-45
21785039-1	2011	Hepcidin has been established as a central regulator of iron metabolism.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
21785039-2	2011	In most patients with chronic kidney disease (CKD), serum hepcidin levels are relatively high, favoring iron sequestration in several cell types and organs and thereby leading to iron-related complications.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	58-66
16999719-7	2006	Ret He is a reliable marker of cellular hemoglobin content and can be used to identify the presence of iron-deficient states.	Iron	103-107	ret proto-oncogene	Homo sapiens	0-3
21785039-2	2011	In most patients with chronic kidney disease (CKD), serum hepcidin levels are relatively high, favoring iron sequestration in several cell types and organs and thereby leading to iron-related complications.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	58-66
21785039-4	2011	Intestinal iron absorption is tightly regulated by both iron stores and hepcidin.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	72-80
21785039-8	2011	Thus, hepcidin might accelerate atherosclerosis by preventing iron exit from macrophages or other cells in the arterial wall.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	6-14
21785039-10	2011	Finally, hepcidin may also play a significant role by itself in the pathogenesis of CKD complications associated with disturbed iron metabolism, i.e. unrelated to ESA hyporesponsiveness, such as bacterial infections and atherosclerosis.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	9-17
16868744-4	2006	Gene regulation of ferritin, long known to depend on iron and, in animals, on a noncoding messenger RNA (mRNA) structure linked in a combinatorial array to functionally related mRNA of iron transport, has recently been shown to be linked to an array of proteins for antioxidant responses such as thioredoxin and quinone reductases.	Iron	53-57	thioredoxin	Homo sapiens	296-307
16868744-4	2006	Gene regulation of ferritin, long known to depend on iron and, in animals, on a noncoding messenger RNA (mRNA) structure linked in a combinatorial array to functionally related mRNA of iron transport, has recently been shown to be linked to an array of proteins for antioxidant responses such as thioredoxin and quinone reductases.	Iron	185-189	thioredoxin	Homo sapiens	296-307
21757620-3	2011	AMH correlated with non-transferrin-bound iron (NTBI), suggesting a role of labile iron in the pathogenesis of decreased reproductive capacity, possibly occurring in parallel to cardiac iron toxicity, as cardiac iron was associated with the presence of amenorrhea and with NTBI levels.	Iron	83-87	anti-Mullerian hormone	Homo sapiens	0-3
16893896-0	2006	Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.	Iron	126-130	transferrin receptor 2	Homo sapiens	58-80
16893896-1	2006	HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis.	Iron	82-86	transferrin receptor 2	Homo sapiens	8-30
16893896-1	2006	HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis.	Iron	82-86	transferrin receptor 2	Homo sapiens	32-36
21757620-3	2011	AMH correlated with non-transferrin-bound iron (NTBI), suggesting a role of labile iron in the pathogenesis of decreased reproductive capacity, possibly occurring in parallel to cardiac iron toxicity, as cardiac iron was associated with the presence of amenorrhea and with NTBI levels.	Iron	83-87	anti-Mullerian hormone	Homo sapiens	0-3
21091647-2	2011	The systemic misdistribution of iron, which is further exacerbated by parenteral iron supplementation, is mainly attributable to iron retention exerted on resident macrophages by hepcidin-mediated down-regulation of the iron exporter ferroportin.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	179-187
16787915-7	2006	Consistent with profound defects in iron homeostasis, Hif1alpha-/- yolk sac and/or embryos demonstrated aberrant mRNA levels of hepcidin, Fpn1, Irp1, and frascati.	Iron	36-40	hypoxia inducible factor 1, alpha subunit	Mus musculus	54-63
16386306-6	2006	In the activation step by iron, there are two possible pathways for developing C-4 free radical: (a) 1.5 H-shift and (b) C-C cleavage.	Iron	26-30	complement C4A (Rodgers blood group)	Homo sapiens	79-82
21091647-2	2011	The systemic misdistribution of iron, which is further exacerbated by parenteral iron supplementation, is mainly attributable to iron retention exerted on resident macrophages by hepcidin-mediated down-regulation of the iron exporter ferroportin.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	179-187
21091647-2	2011	The systemic misdistribution of iron, which is further exacerbated by parenteral iron supplementation, is mainly attributable to iron retention exerted on resident macrophages by hepcidin-mediated down-regulation of the iron exporter ferroportin.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	179-187
21091647-2	2011	The systemic misdistribution of iron, which is further exacerbated by parenteral iron supplementation, is mainly attributable to iron retention exerted on resident macrophages by hepcidin-mediated down-regulation of the iron exporter ferroportin.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	179-187
21720790-0	2011	Proanthocyanidins inhibit iron absorption from soybean (Glycine max) seed ferritin in rats with iron deficiency anemia.	Iron	26-30	ferritin-1, chloroplastic	Glycine max	74-82
21755988-9	2011	This supports a model in which Hsp70 binding to apo-nNOS stabilizes an open state of the heme/substrate binding cleft to facilitate thioredoxin access to the active site cysteine that coordinates with heme iron, permitting heme binding and dimerization to the active enzyme.	Iron	206-210	thioredoxin	Homo sapiens	132-143
21510925-7	2011	The clinical role of hepcidin, the iron modulating protein, is undetermined at this time.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	21-29
21726084-0	2011	Inactivation of MS2 coliphage by ferrous ion and zero-valent iron nanoparticles.	Iron	61-65	MS2	Homo sapiens	16-19
21726084-1	2011	This study demonstrates the inactivation of MS2 coliphage (MS2) by nano particulate zerovalent iron (nZVI) and ferrous ion (Fe[II]) in aqueous solution.	Iron	95-99	MS2	Homo sapiens	44-47
21726084-1	2011	This study demonstrates the inactivation of MS2 coliphage (MS2) by nano particulate zerovalent iron (nZVI) and ferrous ion (Fe[II]) in aqueous solution.	Iron	95-99	MS2	Homo sapiens	59-62
21810240-1	2011	BACKGROUND: Hepcidin serves as a major regulator of systemic iron metabolism and immune function.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	12-20
21810240-6	2011	Inductively coupled plasma mass spectroscopy (ICP-MS) was used to determine whether hepcidin altered iron transport in either NHBE cells or primary alveolar macrophages.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	84-92
21672148-8	2011	In vivo rapamycin treatment induced higher degree of RICTOR and AKT Ser(473) expression directly correlating with long-term rapamycin exposure, FE(PO4) and HOMA index.	Iron	144-146	RPTOR independent companion of MTOR complex 2	Homo sapiens	53-59
21515435-1	2011	Lactoferrin, an iron-binding glycoprotein present in milk and other exocrine secretions in mammals, is anabolic to bone at physiological concentrations.	Iron	16-20	lactotransferrin	Mus musculus	0-11
21508121-2	2011	Hepcidin, a key regulator of iron metabolism, is reduced in iron deficiency.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
21508121-8	2011	The 95% reference range of hepcidin concentration in the iron-replete population was 8.2-199.7 ng/mL.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	27-35
21508121-11	2011	CONCLUSIONS: Serum hepcidin concentration may be a useful indicator of deficient iron stores.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	19-27
21851232-8	2011	Then we assessed the effect of iron on the expression of FurA in MTB H37Rv and we concluded that iron does not affect FurA expression.	Iron	31-35	ferric uptake regulation protein FurA	Mycobacterium tuberculosis H37Rv	57-61
21733088-0	2011	Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
21733088-0	2011	Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	0-8
21733088-2	2011	Hepcidin is the key regulator of iron homeostasis controlling iron absorption and macrophage release.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
21733088-2	2011	Hepcidin is the key regulator of iron homeostasis controlling iron absorption and macrophage release.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
21733088-3	2011	AIM: To investigate hepcidin regulation by iron in DIOS.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	20-28
21417913-2	2011	The role played by hepcidin, the master regulatory hormone of systemic iron metabolism, in the pathogenesis of NAFLD remains controversial.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	19-27
21417913-7	2011	Multivariable regression analyses in patients with NAFLD showed that hepcidin levels were positively associated with total cholesterol (beta=6.9, t=3.3, P&lt;0.01) and triglycerides (beta=1.4, t=2.4, P&lt;0.05), but not with iron parameters, histological staging, and pathological characteristics of NAFLD.	Iron	225-229	hepcidin antimicrobial peptide	Homo sapiens	69-77
21873967-5	2011	CHE was also directly correlated to cholesterol, iron binding capacity, hematocrit, prothrombin activity, and inversely correlated to bilirubin and to presence of sepsis or liver dysfunction (P&lt;0.0001 for all).	Iron	49-53	butyrylcholinesterase	Homo sapiens	0-3
19775775-7	2011	Oxidative stress, also associated with elevated cellular iron, is associated with increased tau phosphorylation at the same sites as seen in H63D cells and treatment with Trolox, an anti-oxidant, lowered tau phosphorylation.	Iron	57-61	microtubule associated protein tau	Homo sapiens	92-95
19775775-7	2011	Oxidative stress, also associated with elevated cellular iron, is associated with increased tau phosphorylation at the same sites as seen in H63D cells and treatment with Trolox, an anti-oxidant, lowered tau phosphorylation.	Iron	57-61	microtubule associated protein tau	Homo sapiens	204-207
19775775-8	2011	These results suggest H63D HFE increases tau phosphorylation via GSK-3beta activity and iron-mediated oxidative stress.	Iron	88-92	microtubule associated protein tau	Homo sapiens	41-44
20392616-2	2011	Conflicting data have been reported on the role of iron in atherosclerosis, with recent data suggesting that excess iron induces vascular damage by increasing levels of the hormone hepcidin, which would determine iron trapping into macrophages, oxidative stress, and promotion of transformation into foam cells.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	181-189
20392616-2	2011	Conflicting data have been reported on the role of iron in atherosclerosis, with recent data suggesting that excess iron induces vascular damage by increasing levels of the hormone hepcidin, which would determine iron trapping into macrophages, oxidative stress, and promotion of transformation into foam cells.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	181-189
21190261-4	2011	The cardiovascular magnetic resonance (CMR) index of cardiac iron used clinically, the effective transverse relaxation rate (R(2)*), is principally influenced by hemosiderin iron and changes only slowly over several months, even with intensive iron-chelating therapy.	Iron	61-65	ribonucleotide reductase regulatory subunit M2	Homo sapiens	125-130
21190261-4	2011	The cardiovascular magnetic resonance (CMR) index of cardiac iron used clinically, the effective transverse relaxation rate (R(2)*), is principally influenced by hemosiderin iron and changes only slowly over several months, even with intensive iron-chelating therapy.	Iron	174-178	ribonucleotide reductase regulatory subunit M2	Homo sapiens	125-130
21190261-4	2011	The cardiovascular magnetic resonance (CMR) index of cardiac iron used clinically, the effective transverse relaxation rate (R(2)*), is principally influenced by hemosiderin iron and changes only slowly over several months, even with intensive iron-chelating therapy.	Iron	174-178	ribonucleotide reductase regulatory subunit M2	Homo sapiens	125-130
21190261-9	2011	After resuming iron-chelating therapy, significant decreases were observed in the mean myocardial RR(2) (7.8%, p &lt; 0.01) and R(2) (5.5%, p &lt; 0.05), but not in R(2)* (1.7%, p &gt; 0.90).	Iron	15-19	ribonucleotide reductase regulatory subunit M2	Homo sapiens	165-170
21190261-10	2011	Although the difference between changes in RR(2) and R(2) was not significant (p &gt; 0.3), RR(2) was consistently more sensitive than R(2) (and R(2)*) to the resumption of iron-chelating therapy, as judged by the effect sizes of relaxation rate differences detected.	Iron	173-177	ribonucleotide reductase regulatory subunit M2	Homo sapiens	145-150
21901657-0	2011	Hepcidin and ferroportin: the new players in iron metabolism.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
21901657-1	2011	Systemic iron homeostasis is regulated by the interaction of the peptide hormone, hepcidin and the iron exporter, ferroportin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	82-90
21901657-2	2011	Mutations in FPN1, the gene that encodes ferroportin, result in iron-overload disease that shows dominant inheritance and variation in phenotype.	Iron	64-68	solute carrier family 40 member 1	Homo sapiens	13-17
21901658-5	2011	The common downstream mechanism of iron overload in hereditary hemochromatosis is abnormal regulation of the hepcidin-ferroportin axis, leading to a failure to prevent excess iron from entering the circulation.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	109-117
21901658-5	2011	The common downstream mechanism of iron overload in hereditary hemochromatosis is abnormal regulation of the hepcidin-ferroportin axis, leading to a failure to prevent excess iron from entering the circulation.	Iron	175-179	hepcidin antimicrobial peptide	Homo sapiens	109-117
21901658-6	2011	Recent data are starting to unravel the molecular mechanisms by which iron regulates hepcidin production, and has demonstrated a key role for the bone morphogenetic protein-hemojuvelin-SMAD signaling pathway in this process.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	85-93
21901658-6	2011	Recent data are starting to unravel the molecular mechanisms by which iron regulates hepcidin production, and has demonstrated a key role for the bone morphogenetic protein-hemojuvelin-SMAD signaling pathway in this process.	Iron	70-74	bone morphogenetic protein 1	Homo sapiens	146-172
16842975-4	2006	In this study, we assayed ceruloplasmin by two enzymatic assays, a standard clinical laboratory p-phenylenediamine oxidation assay and a second assay based on the rate of the oxidation and incorporation of iron (Fe3+) into transferrin; we assayed ferroxidase II activity using this second iron oxidation assay.	Iron	206-210	ceruloplasmin	Homo sapiens	26-39
16842975-4	2006	In this study, we assayed ceruloplasmin by two enzymatic assays, a standard clinical laboratory p-phenylenediamine oxidation assay and a second assay based on the rate of the oxidation and incorporation of iron (Fe3+) into transferrin; we assayed ferroxidase II activity using this second iron oxidation assay.	Iron	289-293	ceruloplasmin	Homo sapiens	26-39
21901658-6	2011	Recent data are starting to unravel the molecular mechanisms by which iron regulates hepcidin production, and has demonstrated a key role for the bone morphogenetic protein-hemojuvelin-SMAD signaling pathway in this process.	Iron	70-74	hemojuvelin BMP co-receptor	Homo sapiens	173-184
16908409-0	2006	NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1.	Iron	58-62	ras related dexamethasone induced 1	Homo sapiens	90-97
21901660-3	2011	The non- HFE hemochromatosis syndromes identifies a subgroup of hereditary iron loading disorders that share with classic HFE-hemochromatosis, the autosomal recessive trait, the pathogenic basis (i.e., lack of hepcidin synthesis or activity), and key clinical features.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	210-218
16908409-4	2006	PAP7 in turn binds to the divalent metal transporter (DMT1), an iron import channel.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	54-58
21789471-3	2011	At the systemic level, iron homeostasis is regulated by the liver peptide hepcidin.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	74-82
16908409-5	2006	We have identified a signaling cascade in neurons whereby stimulation of NMDA receptors activates nNOS, leading to S-nitrosylation and activation of Dexras1, which, via PAP7 and DMT1, physiologically induces iron uptake.	Iron	208-212	ras related dexamethasone induced 1	Homo sapiens	149-156
16908409-5	2006	We have identified a signaling cascade in neurons whereby stimulation of NMDA receptors activates nNOS, leading to S-nitrosylation and activation of Dexras1, which, via PAP7 and DMT1, physiologically induces iron uptake.	Iron	208-212	solute carrier family 11 member 2	Homo sapiens	178-182
16908409-6	2006	As selective iron chelation prevents NMDA neurotoxicity in cortical cultures, the NMDA-NO-Dexras1-PAP7-DMT1-iron uptake signaling cascade also appears to mediate NMDA neurotoxicity.	Iron	108-112	ras related dexamethasone induced 1	Homo sapiens	90-97
16908409-6	2006	As selective iron chelation prevents NMDA neurotoxicity in cortical cultures, the NMDA-NO-Dexras1-PAP7-DMT1-iron uptake signaling cascade also appears to mediate NMDA neurotoxicity.	Iron	108-112	solute carrier family 11 member 2	Homo sapiens	103-107
16609065-4	2006	Now, through homology, expression, and functional studies, we characterize all 4 members of this protein family and demonstrate that 3 of them, Steap2, Steap3, and Steap4, are not only ferrireductases but also cupric reductases that stimulate cellular uptake of both iron and copper in vitro.	Iron	267-271	STEAP2 metalloreductase	Homo sapiens	144-150
21789471-7	2011	Studies of the hepcidin regulation by iron and inflammatory cytokines are revealing new pathways that might become targets of new therapeutic intervention in iron disorders.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	15-23
21618572-0	2011	Liver and serum iron: discrete regulators of hepatic hepcidin expression.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	53-61
16621968-1	2006	Hepcidin, a key regulator of iron metabolism, is expressed in the liver, distributed in blood, and excreted in urine.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
16621968-7	2006	Hepcidin-25 was found to accumulate in the serum of patients receiving hemodialysis; this could contribute to the pathogenesis of renal anemia by decreasing the available iron for hematopoiesis.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	0-8
16721761-9	2006	These results demonstrate that GPx1 contributes to the rapid clearance of H(2)O(2) by mouse astrocytes and that both GPx1 and a high concentration of glutathione are required to protect these cells from iron-dependent peroxide damage.	Iron	203-207	glutathione peroxidase 1	Mus musculus	117-121
21598363-0	2011	Photoelectric protein nanofibrils of alpha-synuclein with embedded iron and phthalocyanine tetrasulfonate.	Iron	67-71	synuclein alpha	Homo sapiens	37-52
16386362-6	2006	Nitroso compounds (MNX, DNX, and TNX), nitrate, nitrite and nitrous oxide were identified as the main by-products for the RDX reduction by ZVI.	Iron	139-142	keratin 86	Homo sapiens	19-22
16841247-0	2006	Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells.	Iron	87-91	beta-2-microglobulin	Homo sapiens	27-46
21574560-3	2011	These results help clarify the nature of the reaction intermediate, supporting a direct interaction between the unique fourth Fe in the cluster and C2 and O3 of the ligand.	Iron	126-128	complement C2	Homo sapiens	148-157
16863914-0	2006	Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins.	Iron	185-189	class II transactivator	Mus musculus	0-23
16863914-12	2006	CONCLUSIONS: Myelosuppressive effects of iron-binding proteins HF and LF and chemokines CCL3, CXCL5, and CXCL8 on mouse bone marrow HPC require expression of MHC class II antigens, and CIITA is involved in this responsiveness through its regulation of expression of MHC class II antigens.	Iron	41-45	class II transactivator	Mus musculus	185-190
21346155-1	2011	Iron homeostasis-related genes (e.g., Dmt1 and Dcytb) are upregulated by hypoxia-inducible factor 2alpha (HIF2alpha) during iron deficiency in the mammalian intestine.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	38-42
16815956-3	2006	YSL1 and YSL3 are similar to the maize (Zea mays) YS1 phytosiderophore transporter (ZmYS1) and the AtYSL2 iron (Fe)-nicotianamine transporter, and are predicted to transport metal-nicotianamine complexes into cells.	Iron	112-114	YELLOW STRIPE like 2	Arabidopsis thaliana	99-105
21346155-1	2011	Iron homeostasis-related genes (e.g., Dmt1 and Dcytb) are upregulated by hypoxia-inducible factor 2alpha (HIF2alpha) during iron deficiency in the mammalian intestine.	Iron	0-4	endothelial PAS domain protein 1	Homo sapiens	73-104
16790283-4	2006	Hepcidin acts by binding to and inducing the degradation of the cellular iron exporter, ferroportin, found in sites of major iron flows: duodenal enterocytes involved in iron absorption, macrophages that recycle iron from senescent erythrocytes, and hepatocytes that store iron.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	0-8
21346155-1	2011	Iron homeostasis-related genes (e.g., Dmt1 and Dcytb) are upregulated by hypoxia-inducible factor 2alpha (HIF2alpha) during iron deficiency in the mammalian intestine.	Iron	0-4	endothelial PAS domain protein 1	Homo sapiens	106-115
21346155-2	2011	Menkes copper ATPase (Atp7a) gene expression is also strongly induced in the duodenum of iron-deficient rats.	Iron	89-93	ATPase copper transporting alpha	Rattus norvegicus	22-27
16766055-6	2006	A combination of classical genetics, differential expression and genomic analysis has led to the identification of homologues of components known to operate in fungi and animals (e.g., Fox1, Ftr1, Fre1, Fer1, Ctr1/2) as well as novel molecules involved in copper and iron nutrition (Crr1, Fea1/2).	Iron	267-271	uncharacterized protein	Chlamydomonas reinhardtii	197-201
21346155-14	2011	In conclusion, the Atp7a gene is upregulated by direct interaction with HIF2alpha, demonstrating coordinate regulation with genes related to intestinal iron homeostasis.	Iron	152-156	ATPase copper transporting alpha	Rattus norvegicus	19-24
16790283-3	2006	Extracellular iron concentrations are controlled by a peptide hormone hepcidin, which inhibits the supply of iron into plasma.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	70-78
16790283-3	2006	Extracellular iron concentrations are controlled by a peptide hormone hepcidin, which inhibits the supply of iron into plasma.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	70-78
21286947-2	2011	To date, mutations in the following genes have been associated with neurodegeneration with brain iron accumulation (NBIA) phenotypes: PANK2, PLA2G6, FA2H, ATP13A2, C2orf37, CP, and FTL.	Iron	97-101	ceruloplasmin	Homo sapiens	173-175
16790283-4	2006	Hepcidin acts by binding to and inducing the degradation of the cellular iron exporter, ferroportin, found in sites of major iron flows: duodenal enterocytes involved in iron absorption, macrophages that recycle iron from senescent erythrocytes, and hepatocytes that store iron.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
16790283-4	2006	Hepcidin acts by binding to and inducing the degradation of the cellular iron exporter, ferroportin, found in sites of major iron flows: duodenal enterocytes involved in iron absorption, macrophages that recycle iron from senescent erythrocytes, and hepatocytes that store iron.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	0-8
21622183-1	2011	Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting step in the metabolism of free heme into equimolar amounts of ferrous iron, carbon monoxide (CO), and biliverdin.	Iron	124-136	heme oxygenase 1	Homo sapiens	0-16
16891003-4	2006	Inappropriate levels of hepcidin, the iron hormone, appear now as the central pathogenic event in all forms of hemochromatosis: depending on the protein involved, and its effect on hepatic production of hepcidin, the phenotype varies, ranging from massive early-onset iron loading with severe organ disease (e.g., associated with homozygous mutations of hemojuvelin or hepcidin itself) to the milder late-onset phenotype characterizing the classic and highly prevalent HFE-related form or the rare transferrin receptor 2-related form.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	24-32
16891003-4	2006	Inappropriate levels of hepcidin, the iron hormone, appear now as the central pathogenic event in all forms of hemochromatosis: depending on the protein involved, and its effect on hepatic production of hepcidin, the phenotype varies, ranging from massive early-onset iron loading with severe organ disease (e.g., associated with homozygous mutations of hemojuvelin or hepcidin itself) to the milder late-onset phenotype characterizing the classic and highly prevalent HFE-related form or the rare transferrin receptor 2-related form.	Iron	268-272	hepcidin antimicrobial peptide	Homo sapiens	24-32
16790587-0	2006	DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis.	Iron	85-89	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
21622183-1	2011	Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting step in the metabolism of free heme into equimolar amounts of ferrous iron, carbon monoxide (CO), and biliverdin.	Iron	124-136	heme oxygenase 1	Homo sapiens	18-22
21492976-9	2011	The enhanced SOD-capacity observed at protein level corresponded with an enhanced expression of iron SOD (FSD1) located in the plastids.	Iron	96-100	Fe superoxide dismutase 1	Arabidopsis thaliana	106-110
16734456-3	2006	The two iron atoms interact with each other through the pi-conjugation of the cyclophenacene, as revealed by differential pulse voltammetric analysis of the D5d Fe2(C60Me10)Cp2.	Iron	8-12	ceruloplasmin	Homo sapiens	173-176
16936810-0	2006	Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women.	Iron	72-76	lactotransferrin	Bos taurus	23-34
16936810-4	2006	In our study, 300 women at different trimesters of pregnancy were enrolled in a trial of oral administration of ferrous sulfate (520 mg once a day) or 30% iron-saturated bovine lactoferrin (bLf) (100 mg twice a day).	Iron	155-159	lactotransferrin	Bos taurus	177-188
21591022-0	2011	Reduced transverse relaxation rate (RR2) for improved sensitivity in monitoring myocardial iron in thalassemia.	Iron	91-95	ribonucleotide reductase regulatory subunit M2	Homo sapiens	36-39
16936810-9	2006	These findings lead us to hypothesize that lactoferrin could influence iron homeostasis directly or through other proteins involved in iron transport out of the intestinal cells into the blood.	Iron	71-75	lactotransferrin	Bos taurus	43-54
16936810-9	2006	These findings lead us to hypothesize that lactoferrin could influence iron homeostasis directly or through other proteins involved in iron transport out of the intestinal cells into the blood.	Iron	135-139	lactotransferrin	Bos taurus	43-54
16769583-0	2006	The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	57-65
21591022-1	2011	PURPOSE: To evaluate the reduced transverse relaxation rate (RR2), a new relaxation index which has been shown recently to be primarily sensitive to intracellular ferritin iron, as a means of detecting short-term changes in myocardial storage iron produced by iron-chelating therapy in transfusion-dependent thalassemia patients.	Iron	172-176	ribonucleotide reductase regulatory subunit M2	Homo sapiens	61-64
16769583-1	2006	Hepcidin production is homeostatically regulated by iron stores, anemia and hypoxia.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
16769583-3	2006	Liver hepcidin mRNA levels correlated with hemoglobin concentration and inversely correlated with serum transferrin receptor, erythropoietin and non-transferrin-bound iron.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	6-14
21591022-1	2011	PURPOSE: To evaluate the reduced transverse relaxation rate (RR2), a new relaxation index which has been shown recently to be primarily sensitive to intracellular ferritin iron, as a means of detecting short-term changes in myocardial storage iron produced by iron-chelating therapy in transfusion-dependent thalassemia patients.	Iron	243-247	ribonucleotide reductase regulatory subunit M2	Homo sapiens	61-64
16769583-5	2006	Urinary hepcidin levels were disproportionably suppressed in regards to iron burden.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	8-16
21591022-1	2011	PURPOSE: To evaluate the reduced transverse relaxation rate (RR2), a new relaxation index which has been shown recently to be primarily sensitive to intracellular ferritin iron, as a means of detecting short-term changes in myocardial storage iron produced by iron-chelating therapy in transfusion-dependent thalassemia patients.	Iron	243-247	ribonucleotide reductase regulatory subunit M2	Homo sapiens	61-64
16769583-6	2006	We conclude that hepcidin expression is regulated mainly by increased erythropoietic activity rather than by iron load and that hepcidin plays a central regulatory role in iron circulation and iron toxicity in patients with thalassemia.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	128-136
16769583-6	2006	We conclude that hepcidin expression is regulated mainly by increased erythropoietic activity rather than by iron load and that hepcidin plays a central regulatory role in iron circulation and iron toxicity in patients with thalassemia.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	128-136
21591022-6	2011	CONCLUSION: These initial results demonstrate that significant differences in RR2 are detectable after a single week of changes in iron-chelating therapy, likely as a result of superior sensitivity to soluble ferritin iron, which is in close equilibrium with the chelatable cytosolic iron pool.	Iron	131-135	ribonucleotide reductase regulatory subunit M2	Homo sapiens	78-81
21591022-7	2011	RR2 measurement may provide a new means of monitoring the short-term effectiveness of iron-chelating agents in patients with myocardial iron overload.	Iron	86-90	ribonucleotide reductase regulatory subunit M2	Homo sapiens	0-3
21591022-7	2011	RR2 measurement may provide a new means of monitoring the short-term effectiveness of iron-chelating agents in patients with myocardial iron overload.	Iron	136-140	ribonucleotide reductase regulatory subunit M2	Homo sapiens	0-3
21586874-6	2011	Levels of the iron-binding protein lactoferrin decreased significantly (p &lt; 0.05) after weaning.	Iron	14-18	lactotransferrin	Bos taurus	35-46
16714573-4	2006	iha from strain UCB34 demonstrated a siderophore receptor phenotype when cloned in a catecholate siderophore receptor-negative E. coli K-12 strain, as shown by growth promotion experiments and uptake of (55)Fe complexed to enterobactin or its linear 2, 3-dihydroxybenzoylserine (DHBS) siderophore derivatives.	Iron	207-209	bifunctional enterobactin receptor/adhesin protein	Escherichia coli	0-3
16714573-8	2006	iha expression was regulated by the ferric uptake regulator Fur and by iron availability, as shown by real-time reverse transcriptase PCR.	Iron	71-75	bifunctional enterobactin receptor/adhesin protein	Escherichia coli	0-3
21315066-1	2011	BACKGROUND: Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage.	Iron	107-111	ceruloplasmin	Homo sapiens	33-46
16460831-0	2006	Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
16460831-1	2006	BACKGROUND/AIMS: The antimicrobial peptide hepcidin is generated in the liver and released into the circulation in response to iron, oxygen and inflammatory signals.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	43-51
16460831-2	2006	Hepcidin serves as a hormonal regulator of duodenal iron absorption and iron trafficking in the reticuloendothelial system.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
16460831-2	2006	Hepcidin serves as a hormonal regulator of duodenal iron absorption and iron trafficking in the reticuloendothelial system.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
16460831-4	2006	METHODS: Hepcidin-mediated iron efflux and parameters of cellular iron homeostasis were studied in THP1 monocytic cells co-cultured with hepcidin-producing hepatic cells.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	9-17
16460831-7	2006	Importantly, hepcidin expression from Huh7 cells elicited a decrease in the levels of the iron-sensitive post-transcriptional regulator IRP2 in THP1 cells, accompanied by de novo synthesis of the iron storage protein ferritin.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	13-21
16460831-7	2006	Importantly, hepcidin expression from Huh7 cells elicited a decrease in the levels of the iron-sensitive post-transcriptional regulator IRP2 in THP1 cells, accompanied by de novo synthesis of the iron storage protein ferritin.	Iron	196-200	hepcidin antimicrobial peptide	Homo sapiens	13-21
16460831-8	2006	CONCLUSIONS: Physiologically generated hepcidin inhibits iron efflux and promotes iron accumulation in monocytic cells, mimicking a pathophysiological response commonly observed in the anemia of inflammation.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	39-47
21315066-1	2011	BACKGROUND: Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage.	Iron	107-111	ceruloplasmin	Homo sapiens	48-50
16460831-8	2006	CONCLUSIONS: Physiologically generated hepcidin inhibits iron efflux and promotes iron accumulation in monocytic cells, mimicking a pathophysiological response commonly observed in the anemia of inflammation.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	39-47
16460831-9	2006	Our results highlight the crucial role of hepcidin in the control of macrophage iron homeostasis.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	42-50
21367862-9	2011	Therefore, just as with knock-out of Nar1 in yeast, we find that knock-out of Iop1/Narfl in mice results in lethality and defective cytosolic iron-sulfur cluster assembly.	Iron	142-146	cytosolic iron-sulfur assembly component 3	Mus musculus	78-82
21136275-1	2011	BACKGROUND: Hepcidin is a liver-derived peptide hormone regulating iron metabolism.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	12-20
16386946-1	2006	Three iron(III) complexes (1-3) of 2-benzoylpyridine N(4)-phenyl thiosemicarbazone (HL1) and one iron(III) complex (4) of 2-benzoylpyridine N(4)-cyclohexyl thiosemicarbazone (HL2) were synthesized and characterized by means of different physicochemical techniques viz., molar conductivity measurements, magnetic susceptibility studies and electronic, infrared and EPR spectral studies.	Iron	6-10	intelectin 1	Homo sapiens	84-87
21136275-11	2011	In healthy subjects and HCV patients, hepcidin levels were correlated with iron and transferrin saturation; no correlation was observed in the hemochromatotic patients.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	38-46
16686545-2	2006	The extrapolated affinity constants beta(1), beta(2), and beta(3)( )()for iron(III) in aqueous solution were 9.95, 18.69, and 26.02, respectively, with a corresponding pFe(3+) value of 14.64.	Iron	74-78	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	58-64
21389184-5	2011	Serum ferritin and plasma hepcidin were correlated (r = 0.66; P&lt;0.001) and both were significant predictors of iron bioavailability, but their combined effect explained only 30% of the inter-individual variation (P&lt;0.001) and illustrates the current lack of understanding of mechanisms responsible for the fine-tuning of iron absorption.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	26-34
16439678-0	2006	Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload.	Iron	99-103	doublesex and mab-3 related transcription factor 1	Homo sapiens	14-18
16439678-4	2006	We report a compound heterozygote for 2 new DMT1 mutations, associated with microcytic anemia from birth and progressive liver iron overload.	Iron	127-131	doublesex and mab-3 related transcription factor 1	Homo sapiens	44-48
20369315-7	2011	When adults were compared, iron-treated animals presented significantly higher Par-4 and caspase-3 immunoreactivities in CA1, CA3 and cortex.	Iron	27-31	carbonic anhydrase 1	Rattus norvegicus	121-124
16634833-1	2006	Hepcidin evolves as a potent hepatocyte-derived regulator of the body"s iron distribution piloting the flow of iron via, and directly binding, to the cellular iron exporter ferroportin.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	0-8
16634833-1	2006	Hepcidin evolves as a potent hepatocyte-derived regulator of the body"s iron distribution piloting the flow of iron via, and directly binding, to the cellular iron exporter ferroportin.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	0-8
16634833-1	2006	Hepcidin evolves as a potent hepatocyte-derived regulator of the body"s iron distribution piloting the flow of iron via, and directly binding, to the cellular iron exporter ferroportin.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	0-8
16634833-2	2006	The hepcidin-ferroportin axis dominates the iron egress from all cellular compartments that are critical to iron homeostasis, namely placental syncytiotrophoblasts, duodenal enterocytes, hepatocytes and macrophages of the reticuloendothelial system.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	4-12
16634833-2	2006	The hepcidin-ferroportin axis dominates the iron egress from all cellular compartments that are critical to iron homeostasis, namely placental syncytiotrophoblasts, duodenal enterocytes, hepatocytes and macrophages of the reticuloendothelial system.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	4-12
21682768-3	2011	Unnecessary iron supplementation also accelerates hepcidin (HP) production.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	50-58
16634833-3	2006	The gene that encodes hepcidin expression (HAMP) is subject to regulation by proinflammatory cytokines, such as IL-6 and IL-1; excessive hepcidin production explains the relative deficiency of iron during inflammatory states, eventually resulting in the anaemia of inflammation.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	22-30
16634833-3	2006	The gene that encodes hepcidin expression (HAMP) is subject to regulation by proinflammatory cytokines, such as IL-6 and IL-1; excessive hepcidin production explains the relative deficiency of iron during inflammatory states, eventually resulting in the anaemia of inflammation.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	43-47
16634833-3	2006	The gene that encodes hepcidin expression (HAMP) is subject to regulation by proinflammatory cytokines, such as IL-6 and IL-1; excessive hepcidin production explains the relative deficiency of iron during inflammatory states, eventually resulting in the anaemia of inflammation.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	137-145
16634833-6	2006	The engineered generation of hepcidin agonists, mimetics or antagonists could largely broaden current therapeutic strategies to redirect the flow of iron.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	29-37
21682768-3	2011	Unnecessary iron supplementation also accelerates hepcidin (HP) production.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	60-62
16133010-6	2006	RESULTS: The DSS+iron group showed a significant increase in inflammatory scores, MPO, TNF-alpha, IL-1, LPO and NF-kappaB activity compared to DSS or DSS+vitamin E.	Iron	17-21	myeloperoxidase	Rattus norvegicus	82-85
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-2
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	64-68	solute carrier family 40 member 1	Homo sapiens	22-35
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	64-68	solute carrier family 40 member 1	Homo sapiens	37-41
16651563-1	2006	Nramp (Slc11a1) genes in mammals are associated with the transport of iron and other divalent cations; Nramp1 in macrophages involved in the innate immune response against intracellular pathogens, and Nramp2 with duodenal iron uptake and the transferrin-transferrin-receptor pathway of iron assimilation.	Iron	70-74	solute carrier family 11 member 2	Homo sapiens	201-207
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-2
16651563-1	2006	Nramp (Slc11a1) genes in mammals are associated with the transport of iron and other divalent cations; Nramp1 in macrophages involved in the innate immune response against intracellular pathogens, and Nramp2 with duodenal iron uptake and the transferrin-transferrin-receptor pathway of iron assimilation.	Iron	222-226	solute carrier family 11 member 2	Homo sapiens	201-207
16651563-1	2006	Nramp (Slc11a1) genes in mammals are associated with the transport of iron and other divalent cations; Nramp1 in macrophages involved in the innate immune response against intracellular pathogens, and Nramp2 with duodenal iron uptake and the transferrin-transferrin-receptor pathway of iron assimilation.	Iron	222-226	solute carrier family 11 member 2	Homo sapiens	201-207
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	22-35
16651563-7	2006	Expression within the gut was of significant interest, as mammalian Nramp2 in the gut plays a primary role in the acquisition of dietary iron.	Iron	137-141	solute carrier family 11 member 2	Homo sapiens	68-74
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	37-41
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-2
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	22-35
16476785-4	2006	(p. 1633) demonstrate that the effects of SNP on expression of HO-1 are mainly due to free iron released from SNP in aqueous solution, whereas NO plays a negligible role, if any, as the mediator of response to SNP.	Iron	91-95	heme oxygenase 1	Homo sapiens	63-67
21682768-4	2011	HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	37-41
16476785-5	2006	Downstream effects of iron, after being dissociated from SNP, include increases in intracellular cAMP that are causally linked to subsequent phosphorylation of specific MAPK targets and enhanced HO-1 protein levels.	Iron	22-26	heme oxygenase 1	Homo sapiens	195-199
21346250-2	2011	The iron-regulatory hormone hepcidin, first described 10 years ago, and its receptor and iron channel ferroportin control the dietary absorption, storage, and tissue distribution of iron.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
21346250-3	2011	Hepcidin causes ferroportin internalization and degradation, thereby decreasing iron transfer into blood plasma from the duodenum, from macrophages involved in recycling senescent erythrocytes, and from iron-storing hepatocytes.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
16261603-4	2006	Hepcidin blocks the release of iron from macrophages, hepatocytes, and enterocytes, causing the characteristic hypoferremia associated with this anemia and iron-deprivation of the developing erythrocytes.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
21346250-3	2011	Hepcidin causes ferroportin internalization and degradation, thereby decreasing iron transfer into blood plasma from the duodenum, from macrophages involved in recycling senescent erythrocytes, and from iron-storing hepatocytes.	Iron	203-207	hepcidin antimicrobial peptide	Homo sapiens	0-8
16261603-4	2006	Hepcidin blocks the release of iron from macrophages, hepatocytes, and enterocytes, causing the characteristic hypoferremia associated with this anemia and iron-deprivation of the developing erythrocytes.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	0-8
21346250-4	2011	Hepcidin is feedback regulated by iron concentrations in plasma and the liver and by erythropoietic demand for iron.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
21346250-4	2011	Hepcidin is feedback regulated by iron concentrations in plasma and the liver and by erythropoietic demand for iron.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	0-8
21346250-5	2011	Genetic malfunctions affecting the hepcidin-ferroportin axis are a main cause of iron overload disorders but can also cause iron-restricted anemias.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	35-43
21346250-6	2011	Modulation of hepcidin and ferroportin expression during infection and inflammation couples iron metabolism to host defense and decreases iron availability to invading pathogens.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	14-22
21346250-6	2011	Modulation of hepcidin and ferroportin expression during infection and inflammation couples iron metabolism to host defense and decreases iron availability to invading pathogens.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	14-22
21411349-14	2011	The HJV p.E302K and HAMP p.R59G variants, and the novel SLC40A1 p.G204S mutation may also be linked to primary iron overload but their role in the pathophysiology of HH remain to be elucidated.	Iron	111-115	solute carrier family 40 member 1	Homo sapiens	56-63
21120509-0	2011	Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat.	Iron	14-18	carbonic anhydrase 1	Rattus norvegicus	90-93
21120509-2	2011	We examined the possibility that neuronal iron overload would mediate free radical production and delayed neuronal death (DND) in hippocampal CA1 area after transient forebrain ischemia (TFI).	Iron	42-46	carbonic anhydrase 1	Rattus norvegicus	142-145
21120509-8	2011	The present findings suggest that excessive iron transported from blood mediates slowly evolving oxidative stress and neuronal death in CA1 after TFI, and that targeting iron-mediated oxidative stress holds extended therapeutic time window against an ischemic event.	Iron	44-48	carbonic anhydrase 1	Rattus norvegicus	136-139
21199650-2	2011	It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin.	Iron	139-143	solute carrier family 40 member 1	Homo sapiens	98-105
21199652-1	2011	BACKGROUNDS &amp; AIMS: The mechanism by which hepcidin regulates iron export from macrophages has been well established and is believed to involve degradation of ferroportin.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	47-55
21199652-9	2011	This result was confirmed ex vivo in isolated duodenal segments: 200 nmol/L hepcidin induced a significant reduction in iron transport and DMT1 protein levels but no change in ferroportin levels.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	76-84
21199652-11	2011	CONCLUSIONS: An acute increase in hepcidin concentration reduces intestinal iron absorption through ubiquitin-dependent proteasome degradation of DMT1.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	34-42
21173098-8	2011	Conclusions Our results are consistent with a scenario in which TFR2 plays a prominent and HFE a contributory role in the hepcidin response to a dose of oral iron.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	122-130
21173098-9	2011	In iron-normalized patients with HFE hemochromatosis, both the low baseline hepcidin level and the weak response to iron contribute to hyperabsorption of iron.	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	76-84
21348906-1	2011	AIM:   Hepcidin is a key regulator of systemic iron metabolism and its expression is modulated by hepatitis C virus (HCV) infection.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	7-15
21462044-5	2011	HO-1 is an antioxidant enzyme that catabolizes heme to carbon monoxide, free iron, and biliverdin, all of which are involved in the suppression of inflammatory mediators.	Iron	77-81	heme oxygenase 1	Homo sapiens	0-4
21177266-5	2011	Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	20-33
21177266-5	2011	Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage.	Iron	53-57	solute carrier family 40 member 1	Homo sapiens	20-33
21177266-5	2011	Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage.	Iron	149-153	solute carrier family 40 member 1	Homo sapiens	20-33
21177266-11	2011	REGULATION OF IRON HOMOEOSTASIS: Hepcidin, synthesised by hepatocytes in response to iron concentrations, inflammation, hypoxia and erythropoiesis, is the main iron-regulatory hormone.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	33-41
21177266-11	2011	REGULATION OF IRON HOMOEOSTASIS: Hepcidin, synthesised by hepatocytes in response to iron concentrations, inflammation, hypoxia and erythropoiesis, is the main iron-regulatory hormone.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	33-41
21177266-13	2011	Inappropriate hepcidin secretion may lead to either iron deficiency or iron overload.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	14-22
21177268-3	2011	In chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, resulting in hypoferraemia and iron restricted erythropoiesis, despite normal iron stores (functional iron deficiency), and finally anaemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD+ID).	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	39-47
21177268-3	2011	In chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, resulting in hypoferraemia and iron restricted erythropoiesis, despite normal iron stores (functional iron deficiency), and finally anaemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD+ID).	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	39-47
21177268-3	2011	In chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, resulting in hypoferraemia and iron restricted erythropoiesis, despite normal iron stores (functional iron deficiency), and finally anaemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD+ID).	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	39-47
21177268-3	2011	In chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, resulting in hypoferraemia and iron restricted erythropoiesis, despite normal iron stores (functional iron deficiency), and finally anaemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD+ID).	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	39-47
21346101-2	2011	Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	57-61
21346101-3	2011	Mutations in DMT1 and matriptase-2 cause iron deficiency; mutations in FPN, HFE, and TRF2 cause iron excess.	Iron	41-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	13-17
21346101-6	2011	Integration of the IRE-RNA in translation regulators (near the cap) or turnover elements (after the coding region) increases iron uptake (DMT1/TRF1) or decreases iron storage/efflux (FTN/FPN) when IRP binds.	Iron	125-129	doublesex and mab-3 related transcription factor 1	Homo sapiens	138-142
21421406-3	2011	Enhanced activities of PEPC and/or NADP-ME and/or PPDK were found in plants under various types of abiotic stress, such as drought, high salt concentration, ozone, the absence of phosphate and iron or the presence of heavy metals in the soil.	Iron	193-197	phosphoenolpyruvate carboxykinase 1	Homo sapiens	23-27
16759552-2	2006	The objective of the present study was to ascertain whether the competitive blockade of DMT1 by the administration of high doses of oral Mg2+ reduces iron absorption in patients homozygous for the C282Y mutation.	Iron	150-154	solute carrier family 11 member 2	Homo sapiens	88-92
16537971-5	2006	Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	127-142
16537971-5	2006	Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	127-142
16537971-5	2006	Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	127-142
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	85-89	growth factor receptor bound protein 2-associated protein 2	Mus musculus	41-44
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	91-93	growth factor receptor bound protein 2-associated protein 2	Mus musculus	41-44
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	174-176	growth factor receptor bound protein 2-associated protein 2	Mus musculus	41-44
16596660-1	2006	BACKGROUND AND OBJECTIVES: Enhancement of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) has been demonstrated experimentally using light dose fractionation or CP94 iron chelation.	Iron	178-182	beaded filament structural protein 1	Rattus norvegicus	173-177
16337798-3	2006	Iron was mostly associated with amyloid deposits in APP/PS1 animals, while it was diffuse in the PS1 mice.	Iron	0-4	presenilin 1	Mus musculus	56-59
16337798-3	2006	Iron was mostly associated with amyloid deposits in APP/PS1 animals, while it was diffuse in the PS1 mice.	Iron	0-4	presenilin 1	Mus musculus	97-100
16599945-1	2006	Aceruloplasminemia (ACP) is an inherited disorder of iron metabolism caused by the lack of ceruloplasmin activity; the neuropathological hallmarks are excessive iron deposition, neuronal loss, bizarrely deformed astrocytes, and numerous "grumose or foamy spheroid bodies (GFSBs)".	Iron	53-57	ceruloplasmin	Homo sapiens	1-14
16599945-4	2006	Ceruloplasmin is largely produced by perivascular astrocytes in the central nervous system and exhibits a ferroxidase activity that inhibits iron-associated lipid peroxidation and hydroxyl radical formation; therefore, the lack of ceruloplasmin causes direct oxidative stress on astrocytes.	Iron	141-145	ceruloplasmin	Homo sapiens	0-13
16547137-3	2006	These findings raised renewed interest for time-resolved structural investigations of myoglobin (Mb), a simple heme protein displaying a photosensitive iron-ligand bond.	Iron	152-156	myoglobin	Homo sapiens	86-95
16547137-3	2006	These findings raised renewed interest for time-resolved structural investigations of myoglobin (Mb), a simple heme protein displaying a photosensitive iron-ligand bond.	Iron	152-156	myoglobin	Homo sapiens	97-99
16466700-0	2006	c-Myc over-expression in Ramos Burkitt"s lymphoma cell line predisposes to iron homeostasis disruption in vitro.	Iron	75-79	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
16466700-3	2006	It has been shown that iron induces expression of c-myc which, owing to its transcriptional regulatory functions, regulates genes involved in iron metabolism.	Iron	23-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-55
16466700-3	2006	It has been shown that iron induces expression of c-myc which, owing to its transcriptional regulatory functions, regulates genes involved in iron metabolism.	Iron	142-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-55
16466700-4	2006	Transient enhancement of c-myc expression by iron could increase the expression of genes involved in iron incorporation, which could lead to an accumulation of intracellular free iron.	Iron	45-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
16466700-4	2006	Transient enhancement of c-myc expression by iron could increase the expression of genes involved in iron incorporation, which could lead to an accumulation of intracellular free iron.	Iron	101-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
16466700-4	2006	Transient enhancement of c-myc expression by iron could increase the expression of genes involved in iron incorporation, which could lead to an accumulation of intracellular free iron.	Iron	101-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
16466700-5	2006	Here, we have investigated whether cells with a high basal level of c-Myc were more likely to accumulate free iron.	Iron	110-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	68-73
16466700-8	2006	These modifications in iron metabolism, resulting from the strong basal expression of c-Myc, and amplified by iron addition, could lead to a disruption in homeostasis and consequently to growth arrest.	Iron	23-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	86-91
16467350-2	2006	The mitochondrial ABC half-transporter Abcb7, which is mutated in X-linked sideroblastic anemia with ataxia in humans, is a functional ortholog of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosolic Fe-S cluster assembly.	Iron	246-250	ATP binding cassette subfamily B member 7	Homo sapiens	39-44
16431145-9	2006	Altering luminal saline pH from 7.0 to 5.5 did not affect ferric or ferrous iron uptake, suggesting that if iron is entering via DMT1 in marine fish intestine this transporter works efficiently under circumneutral conditions.	Iron	108-112	solute carrier family 11 member 2	Homo sapiens	129-133
16479545-4	2006	Comparison of transcriptional profiles of infected IL-4- and IFN-gamma-activated macrophages revealed delayed and partially diminished responses to intracellular bacteria in alternatively activated macrophages, characterized by reduced exposure to nitrosative stress and increased iron availability, respectively.	Iron	281-285	interleukin 4	Mus musculus	51-55
16475818-1	2006	The metal transporter DMT1 (Slc11a2) plays a vital role in iron metabolism.	Iron	59-63	solute carrier family 11 member 2	Homo sapiens	22-26
16475818-1	2006	The metal transporter DMT1 (Slc11a2) plays a vital role in iron metabolism.	Iron	59-63	solute carrier family 11 member 2	Homo sapiens	28-35
16475818-2	2006	Alternative splicing of the 3" exon generates two DMT1 isoforms with different C-terminal protein sequences and a 3" untranslated region harboring (isoform I, +IRE) or not (isoform II, -IRE), an iron-responsive element.	Iron	195-199	solute carrier family 11 member 2	Homo sapiens	50-54
16232120-2	2006	Protein and mRNA expression for the +/-IRE (iron response element) forms of DMT1, but not the 1A isoform, were down-regulated within the first few hours upon removal of RA, at which time the cells began to differentiate.	Iron	44-48	solute carrier family 11 member 2	Homo sapiens	76-80
16437160-1	2006	In the budding yeast Saccharomyces cerevisiae, transcription of genes encoding for the high-affinity iron (FET3, FTR1) and copper (CTR1) transporters does not occur in the absence of heme.	Iron	101-105	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	131-135
21185934-3	2011	Under hypoxia, the expression of major iron homeostasis genes including transferrin, transferrin receptor, ceruloplasmin, and heme oxygenase-1 is activated by hypoxia-inducible factors to provide increased iron availability for erythropoiesis in an attempt to enhance oxygen uptake and delivery to hypoxic cells.	Iron	39-43	ceruloplasmin	Homo sapiens	107-120
21246129-5	2011	The DBC(2-) adducts of the iron(III) complexes of bpa, bba and tacn ligands, all with facial coordination, elicit extradiol (E) cleavage to different extents while the adduct of the terpy complex with meridional coordination of the ligand shows always intradiol (I) cleavage.	Iron	27-31	Rho related BTB domain containing 2	Homo sapiens	4-11
16407589-3	2006	Hepcidin, a small peptide synthesized in the liver, controls extracellular iron by regulating its intestinal absorption, placental transport, recycling by macrophages, and release from stores.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
16407589-4	2006	Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin, the sole iron exporter in iron-transporting cells.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
16407589-4	2006	Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin, the sole iron exporter in iron-transporting cells.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	0-8
16407589-4	2006	Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin, the sole iron exporter in iron-transporting cells.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	0-8
16407589-5	2006	In turn, hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	9-17
16407589-6	2006	Hepcidin is markedly induced during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations, and contributing to the anemia of inflammation.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	0-8
16407589-6	2006	Hepcidin is markedly induced during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations, and contributing to the anemia of inflammation.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
21328502-1	2011	A novel bispyrazolylpyridine ligand incorporating lateral phenol groups, H(4)L, has led to an Fe(II) spin-crossover (SCO) complex, [Fe(H(4)L)(2)][ClO(4)](2) H(2)O 2 (CH(3))(2)CO (1), with an intricate network of intermolecular interactions.	Iron	94-96	H4 clustered histone 7	Homo sapiens	73-78
16434742-0	2006	The redox couple of the cytochrome c cyanide complex: the contribution of heme iron ligation to the structural stability, chemical reactivity, and physiological behavior of horse cytochrome c.	Iron	79-83	cytochrome c, somatic	Equus caballus	24-36
16434742-0	2006	The redox couple of the cytochrome c cyanide complex: the contribution of heme iron ligation to the structural stability, chemical reactivity, and physiological behavior of horse cytochrome c.	Iron	79-83	cytochrome c, somatic	Equus caballus	179-191
21292245-4	2011	At first, phytates coordinate iron octahedrally between P2 and P1,3.	Iron	30-34	H3 histone pseudogene 6	Homo sapiens	56-67
16471565-4	2006	The protein"s contribution to Fe motion is dominant at low frequencies, where coupling to the backbone tightly constrains Fe displacements in cytochrome f, in contrast to enhanced heme flexibility in myoglobin.	Iron	30-32	myoglobin	Homo sapiens	200-209
20499129-1	2011	Hepcidin is a key hormone governing mammalian iron homeostasis and may be directly or indirectly involved in the development of most iron deficiency/overload and inflammation-induced anemia.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
16371467-10	2006	However, metal coordination sites composed of four strictly conserved histidine-glutamate sequences were identified, suggesting that DOHH enzymes have convergently evolved an iron-dependent hydroxylation mechanism.	Iron	175-179	deoxyhypusine hydroxylase	Homo sapiens	133-137
16400057-0	2006	Iron absorption from soybean ferritin in nonanemic women.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	29-37
21175851-0	2011	Two novel mutations in the SLC40A1 and HFE genes implicated in iron overload in a Spanish man.	Iron	63-67	solute carrier family 40 member 1	Homo sapiens	27-34
16400057-1	2006	BACKGROUND: Dietary ferritin, a protein cage around an iron mineral, is an underestimated source of bioavailable iron.	Iron	55-59	ferritin-1, chloroplastic	Glycine max	20-28
16400057-3	2006	Iron from animal ferritin is absorbed as well as is iron from FeSO4 in women.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	17-25
21380928-0	2011	Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13).	Iron	50-54	ATP binding cassette subfamily B member 7	Homo sapiens	8-13
16400057-4	2006	OBJECTIVE: The objective was to examine iron absorption from purified soybean ferritin.	Iron	40-44	ferritin-1, chloroplastic	Glycine max	78-86
21380928-4	2011	We identify the loss of the ABCB7 (ATP-binding cassette subfamily B member-7) gene, which is located on Xq13 and is involved in mitochondrial iron transport to the cytosol, by fluorescent in situ hybridization (FISH) analysis and the decreased expression level of ABCB7 mRNA in the patient"s bone marrow cells.	Iron	142-146	ATP binding cassette subfamily B member 7	Homo sapiens	28-33
16621758-1	2006	Lactoferrin (Lf) is an iron-binding protein and belongs to the serum transferrin family.	Iron	23-27	lactotransferrin	Bos taurus	0-11
21380928-4	2011	We identify the loss of the ABCB7 (ATP-binding cassette subfamily B member-7) gene, which is located on Xq13 and is involved in mitochondrial iron transport to the cytosol, by fluorescent in situ hybridization (FISH) analysis and the decreased expression level of ABCB7 mRNA in the patient"s bone marrow cells.	Iron	142-146	ATP binding cassette subfamily B member 7	Homo sapiens	264-269
16621758-1	2006	Lactoferrin (Lf) is an iron-binding protein and belongs to the serum transferrin family.	Iron	23-27	lactotransferrin	Bos taurus	13-15
21380928-7	2011	These findings suggest that loss of the ABCB7 gene may be a pathogenetic factor underlying mitochondrial iron accumulation in RARS patients with idicXq13.	Iron	105-109	ATP binding cassette subfamily B member 7	Homo sapiens	40-45
20851655-6	2011	Iron metabolism, absorption, diffusion, storage, and use by the bone marrow are described using published data on transferrin, ferritin, and hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	141-149
16629172-3	2006	The apical divalent metal transporter-1 (DMT1) transports ferrous iron from the lumen into the cells, while the basolateral transporter ferroportin extrudes iron from the enterocytes into the circulation.	Iron	66-70	solute carrier family 11 member 2	Homo sapiens	11-39
16629172-3	2006	The apical divalent metal transporter-1 (DMT1) transports ferrous iron from the lumen into the cells, while the basolateral transporter ferroportin extrudes iron from the enterocytes into the circulation.	Iron	66-70	solute carrier family 11 member 2	Homo sapiens	41-45
16629172-3	2006	The apical divalent metal transporter-1 (DMT1) transports ferrous iron from the lumen into the cells, while the basolateral transporter ferroportin extrudes iron from the enterocytes into the circulation.	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	11-39
16629172-3	2006	The apical divalent metal transporter-1 (DMT1) transports ferrous iron from the lumen into the cells, while the basolateral transporter ferroportin extrudes iron from the enterocytes into the circulation.	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	41-45
16629172-8	2006	These control sites may be influenced by gene therapeutic approaches; one general therapy for hemochromatosis of different etiologies is the inhibition of DMT1 synthesis by antisense-generating genes, which has been shown to markedly inhibit apical iron uptake by intestinal epithelial cells.	Iron	249-253	solute carrier family 11 member 2	Homo sapiens	155-159
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	89-93	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	173-177	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	173-177	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	173-177	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16629180-0	2006	Regulation of transepithelial transport of iron by hepcidin.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	51-59
16629180-3	2006	Lately, Hepc has been considered the "stores regulator," a putative factor that signals the iron content of the body to intestinal cells.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	8-12
16629180-4	2006	In this work, we characterized the effect of Hepc produced by hepatoma cells on iron absorption by intestinal cells.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	45-49
16629180-6	2006	The results indicate that Hepc released by HepG2 inhibited apical iron uptake by Caco-2 cells, probably by inhibiting the expression of the apical transporter DMT1.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	26-30
16629181-0	2006	Heme oxygenase 1 overexpression increases iron fluxes in caco-2 cells.	Iron	42-46	heme oxygenase 1	Homo sapiens	0-16
16629181-2	2006	Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe.	Iron	100-102	heme oxygenase 1	Homo sapiens	0-16
20851655-8	2011	Hepcidin is a hormone that lowers serum iron levels and regulates iron transport across membranes, preventing iron from exiting the enterocytes, macrophages, and hepatocytes.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
20851655-8	2011	Hepcidin is a hormone that lowers serum iron levels and regulates iron transport across membranes, preventing iron from exiting the enterocytes, macrophages, and hepatocytes.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
20851655-8	2011	Hepcidin is a hormone that lowers serum iron levels and regulates iron transport across membranes, preventing iron from exiting the enterocytes, macrophages, and hepatocytes.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
20851655-9	2011	In addition, hepcidin inhibits intestinal iron absorption and iron release from macrophages and hepatocytes.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	13-21
16257244-3	2006	This report describes the clinical and laboratory findings of two Spanish families with autosomal dominant iron overload associated with previously unrecognized Ferroportin 1 mutations (p.R88T and p.I180T).	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	161-174
20851655-9	2011	In addition, hepcidin inhibits intestinal iron absorption and iron release from macrophages and hepatocytes.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	13-21
20851655-10	2011	The action of hepcidin is mediated by binding to the iron exporter ferroportin.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	14-22
16479095-1	2006	BACKGROUND/AIMS: Experimental studies have demonstrated interleukin-6 and iron load induce expression of hepcidin (an iron regulatory peptide), whereas anemia and erythropoietin (EPO) suppress its expression.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	105-113
21156806-8	2011	Under conditions of iron deficiency, rice and barley roots express high levels of TOM1 and HvTOM1, respectively, and the overexpression of these genes increased tolerance to iron deficiency.	Iron	20-24	HvTOM1	Hordeum vulgare	82-86
17181986-1	2006	The discovery of the HFE, HJV, HAMP, TfR2, and SLC40A1 genes and preliminary understanding of their roles in iron homeostasis have contributed tremendously to our understanding of the pathogenesis of genetic hemochromatosis.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	31-35
17181986-1	2006	The discovery of the HFE, HJV, HAMP, TfR2, and SLC40A1 genes and preliminary understanding of their roles in iron homeostasis have contributed tremendously to our understanding of the pathogenesis of genetic hemochromatosis.	Iron	109-113	solute carrier family 40 member 1	Homo sapiens	47-54
21156806-8	2011	Under conditions of iron deficiency, rice and barley roots express high levels of TOM1 and HvTOM1, respectively, and the overexpression of these genes increased tolerance to iron deficiency.	Iron	20-24	HvTOM1	Hordeum vulgare	91-97
16051358-1	2006	Hepcidin is a liver-expressed iron-regulating hormone that also is an antimicrobial peptide.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
21115478-4	2011	All genes identified as suppressors of high iron toxicity in aerobically grown Deltaccc1 cells encode organelle iron transporters including mitochondrial iron transporters MRS3, MRS4, and RIM2.	Iron	44-48	Fe(2+) transporter	Saccharomyces cerevisiae S288C	178-182
16943657-2	2006	HO-1 degradation of heme yields biliverdin, bilirubin, carbon monoxide and iron.	Iron	75-79	heme oxygenase 1	Homo sapiens	0-4
21115478-7	2011	We conclude that Mrs3/Mrs4 can sequester iron within mitochondria under aerobic conditions but not anaerobic conditions.	Iron	41-45	Fe(2+) transporter	Saccharomyces cerevisiae S288C	22-26
16706826-0	2006	Role of transferrin receptor 2 in hepatic accumulation of iron in patients with chronic hepatitis C. BACKGROUND AND AIM: Iron deposition in the liver is a common finding in patients with chronic hepatitis C (CH-C).	Iron	58-62	transferrin receptor 2	Homo sapiens	8-30
16706826-0	2006	Role of transferrin receptor 2 in hepatic accumulation of iron in patients with chronic hepatitis C. BACKGROUND AND AIM: Iron deposition in the liver is a common finding in patients with chronic hepatitis C (CH-C).	Iron	121-125	transferrin receptor 2	Homo sapiens	8-30
21115478-10	2011	Deletion of TSA1, which encodes a peroxiredoxin, exacerbated iron toxicity in Deltaccc1 cells under both aerobic and anaerobic conditions, suggesting a unique role for Tsa1 in iron toxicity.	Iron	61-65	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	12-16
16706826-2	2006	This study assessed if the protein expression of transferrin receptor 2 (TfR2) is upregulated in the liver of patients with CH-C and if TfR2 protein mediates iron accumulation during hepatitis C virus (HCV) infection.	Iron	158-162	transferrin receptor 2	Homo sapiens	136-140
16706826-10	2006	CONCLUSIONS: The protein expression of TfR2 is significantly associated with iron deposition in the liver in patients with CH-C.	Iron	77-81	transferrin receptor 2	Homo sapiens	39-43
16706826-11	2006	HCV infection may affect the hepatic expression of TfR2, leading to iron accumulation in the liver.	Iron	68-72	transferrin receptor 2	Homo sapiens	51-55
21115478-10	2011	Deletion of TSA1, which encodes a peroxiredoxin, exacerbated iron toxicity in Deltaccc1 cells under both aerobic and anaerobic conditions, suggesting a unique role for Tsa1 in iron toxicity.	Iron	176-180	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	12-16
21115478-10	2011	Deletion of TSA1, which encodes a peroxiredoxin, exacerbated iron toxicity in Deltaccc1 cells under both aerobic and anaerobic conditions, suggesting a unique role for Tsa1 in iron toxicity.	Iron	176-180	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	168-172
21077794-0	2011	Hepcidin: the main regulator of iron homeostasis.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
17101715-7	2006	Element assay showed that the contents of Mg, Mn, and Fe in 35S::AtMGT1 plants increased compared with wild-type plants.	Iron	54-56	magnesium transporter 1	Arabidopsis thaliana	65-71
20739232-3	2011	Indeed, deregulation of the transcription of hepcidin, emerging as the master regulator of systemic iron metabolism, has been implicated in the pathogenesis of hepatic iron overload in chronic liver diseases.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	45-53
17447435-3	2006	Metal chelation has the potential to prevent iron-induced oxidative stress and aggregation of alpha-synuclein and beta-amyloid peptides.	Iron	45-49	synuclein alpha	Homo sapiens	94-109
21247219-6	2011	Recently, mechanisms have been proposed to explain the microcytic appearance of this anaemia; these include globin production defect, erythropoietin resistance, chronic inflammation, dysregulation of cellular iron metabolism and hepcidin-mediated iron homeostasis interference.	Iron	247-251	hepcidin antimicrobial peptide	Homo sapiens	229-237
16324801-2	2006	To combat these infections, the mammalian biosystem expresses an iron binding exocrine protein, lactoferrin, which scavenges and competes for free iron, thereby starving the parasite of its vital iron supply.	Iron	65-69	lactotransferrin	Bos taurus	96-107
16324801-2	2006	To combat these infections, the mammalian biosystem expresses an iron binding exocrine protein, lactoferrin, which scavenges and competes for free iron, thereby starving the parasite of its vital iron supply.	Iron	147-151	lactotransferrin	Bos taurus	96-107
16324801-2	2006	To combat these infections, the mammalian biosystem expresses an iron binding exocrine protein, lactoferrin, which scavenges and competes for free iron, thereby starving the parasite of its vital iron supply.	Iron	147-151	lactotransferrin	Bos taurus	96-107
16324801-4	2006	The increase in iron can be induced by several environmental and/or eco-genetic prerequisites that operate either singly or in a synergistic combination; factors such as iron rich water/foods, increased iron uptake/retention in the host tissues or an environmental/genetic induced reduction in the turn over of iron binding lactoferrin mediated immune defence against TB.	Iron	16-20	lactotransferrin	Bos taurus	324-335
16324801-7	2006	The problem is further compounded by the routine use of "anti-lactoferrin" levamisole based cattle wormers, which "sensitise" the levamisole"s target receptors, thereby down regulating the secretion of the iron binding lactoferrin molecule, which causes a reduction in the host"s main line of defence against TB infection.	Iron	206-210	lactotransferrin	Bos taurus	62-73
16324801-7	2006	The problem is further compounded by the routine use of "anti-lactoferrin" levamisole based cattle wormers, which "sensitise" the levamisole"s target receptors, thereby down regulating the secretion of the iron binding lactoferrin molecule, which causes a reduction in the host"s main line of defence against TB infection.	Iron	206-210	lactotransferrin	Bos taurus	219-230
16081762-7	2005	It was found that iron-deficient rats had significantly lower sucrase (19.5% lower) and lactase (56.8% lower) but not IAP-II activity than control rats.	Iron	18-22	lactase	Rattus norvegicus	88-95
16081696-0	2005	Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	130-138
16081696-8	2005	At the subcellular level, hepcidin was shown to induce rapid internalization and degradation of the macrophage iron exporter.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	26-34
16081696-9	2005	These data are consistent with a direct iron export by ferroportin through the plasma membrane of macrophages and strongly support an efficient posttranscriptional down-regulation of ferroportin by hepcidin in these cells.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	198-206
16091455-0	2005	Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	37-41
16091455-0	2005	Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	43-50
16091455-6	2005	We hypothesize that the residual protein in hematopoietic cells represents the functional E399D DMT1 variant, but because of its quantitative reduction, the iron uptake activity of DMT1 in the patient"s erythroid cells is severely suppressed.	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	181-185
16286684-7	2005	Compared to the Cont, group, the plasma erythropoietin concentration was increased by iron deficiency and decreased by zinc deficiency (p &lt; 0.01).	Iron	86-90	erythropoietin	Rattus norvegicus	40-54
16330325-0	2005	A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	70-78
16330325-2	2005	Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
16330325-4	2005	Transcript levels of genes involved in intestinal iron absorption, including Dcytb, DMT1, and ferroportin, are significantly elevated in the absence of hepcidin.	Iron	50-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	84-88
16330325-6	2005	Moreover, transcriptional activation of hepcidin is abrogated in SMAD4-deficient hepatocytes in response to iron overload, TGF-beta, BMP, or IL-6.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	40-48
16166214-6	2005	Inhibition of the hypoxia-dependent IGFBP-1 mRNA induction by actinomycin D indicates that this effect is mediated at the level of gene transcription, and inhibition of IGFBP-1 mRNA by the iron chelator desferrioxamine under both venous and arterial pO(2) suggested the involvement of hypoxia-inducible transcription factors (HIF).	Iron	189-193	insulin-like growth factor binding protein 1	Rattus norvegicus	169-176
16166214-9	2005	Together, these results support the concept that iron, radical oxygen species, and the HIF-2 and -3 as well as the PHD pathways play important roles in mediating effects of hypoxia on IGFBP-1 gene expression in the liver.	Iron	49-53	insulin-like growth factor binding protein 1	Rattus norvegicus	184-191
16249921-4	2005	We propose that the frequently observed iron deficiency of females runners is caused by elevated hepcidin levels.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	97-105
16382951-5	2005	This study examined the effectiveness of commercial zerovalent iron to remove two viruses, phiX174 and MS-2, from water.	Iron	63-67	MS2	Homo sapiens	103-107
16330432-1	2005	BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues.	Iron	125-129	solute carrier family 40 member 1	Homo sapiens	27-40
16330432-1	2005	BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues.	Iron	125-129	solute carrier family 40 member 1	Homo sapiens	42-46
16330432-1	2005	BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues.	Iron	166-170	solute carrier family 40 member 1	Homo sapiens	27-40
16330432-1	2005	BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues.	Iron	166-170	solute carrier family 40 member 1	Homo sapiens	42-46
16330432-5	2005	The iron-responsive element (IRE) in the 5"- untranslated region (UTR) of FPN1 mRNA is functional but, in spite of that, FPN1 protein expression, as well as mRNA level and half-life, seem not to be affected by iron.	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	74-78
16330432-5	2005	The iron-responsive element (IRE) in the 5"- untranslated region (UTR) of FPN1 mRNA is functional but, in spite of that, FPN1 protein expression, as well as mRNA level and half-life, seem not to be affected by iron.	Iron	210-214	solute carrier family 40 member 1	Homo sapiens	74-78
16330432-10	2005	INTERPRETATION AND CONCLUSIONS: This is the first report describing the presence of FPN1 in erythroid cells at all stages of differentiation, providing evidence that erythroid cells possess specific mechanisms of iron export.	Iron	213-217	solute carrier family 40 member 1	Homo sapiens	84-88
16314508-1	2005	The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1.	Iron	38-42	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	241-245
16314508-1	2005	The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1.	Iron	38-42	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	250-255
16314508-1	2005	The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1.	Iron	51-53	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	241-245
16314508-1	2005	The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1.	Iron	51-53	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	250-255
16297069-1	2005	The Arabidopsis Yellow Stripe 1-Like (YSL) proteins have been identified by homology with the maize (Zea mays) Yellow Stripe 1 (YS1) transporter which is responsible for iron-phytosiderophore (PS) uptake by roots in response to iron shortage.	Iron	170-174	iron-phytosiderophore transporter yellow stripe 1	Zea mays	128-131
16297069-1	2005	The Arabidopsis Yellow Stripe 1-Like (YSL) proteins have been identified by homology with the maize (Zea mays) Yellow Stripe 1 (YS1) transporter which is responsible for iron-phytosiderophore (PS) uptake by roots in response to iron shortage.	Iron	228-232	iron-phytosiderophore transporter yellow stripe 1	Zea mays	128-131
16163767-4	2005	Similarly, the reaction of PMAT (15) with Mn(ClO4)2.6H2O or M(BF4)2.6 H2O (M=Fe, Co, Ni, Zn) in a ligand-to-metal molar ratio of 1:1 has afforded a series of complexes with the general formula [M(II) (2)(PMAT)2]X4.	Iron	77-79	solute carrier family 29 member 4	Homo sapiens	27-31
16207483-7	2005	The catalytic properties of the AsAH(2)/Fe(II) combination were explained by taking into account the anti-oxidant and pro-oxidant properties of AsAH(2), as well as the possible formation of an iron/ascorbate complex as the initiator of the ML oxidation.	Iron	193-197	N-acylsphingosine amidohydrolase 2	Homo sapiens	32-39
16274220-2	2005	Mutations in the murine hephaestin gene (sla) produce microcytic, hypochromic anemia that is refractory to oral iron therapy.	Iron	112-116	src-like adaptor	Mus musculus	41-44
16323799-2	2005	In this study, a linear relationship between the pseudo-first-order rate constant (k(obs)) for polyhalogenated alkane reduction and iron mass loading (rhom) was only obtained when reduction appeared to be mass-transport-limited.	Iron	132-136	ras homolog family member D	Homo sapiens	151-155
16323799-5	2005	We obtained strong linear correlations between k(obs) values and the concentration of aqueous iron(ll) generated over a 24 h period in batch systems with that same rhom.	Iron	94-98	ras homolog family member D	Homo sapiens	164-168
16254410-2	2005	A cross-sectional study was performed to assess hepcidin correlations with markers of iron status, erythropoietin therapy and markers of inflammation in hemodialyzed patients and in the healthy volunteers.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	48-56
16154780-1	2005	The mechanism of excessive iron storage in patients with hereditary hemochromatosis caused by mutations of the HFE gene seems to be a failure to up-regulate hepcidin in the face of increased body iron.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	157-165
16150804-1	2005	Increased iron levels of the substantia nigra and the discovery of ceruloplasmin mutations in patients with Parkinson"s disease (PD) imply impaired iron metabolism in this neurodegenerative disorder.	Iron	148-152	ceruloplasmin	Homo sapiens	67-80
16150804-2	2005	Ceruloplasmin has ferroxidase activity oxidizing iron(II) to iron(III).	Iron	49-54	ceruloplasmin	Homo sapiens	0-13
16150804-9	2005	Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD.	Iron	99-103	ceruloplasmin	Homo sapiens	46-59
16283525-3	2005	Here we verify the ability of nickel to enter the cell via the divalent metal ion transporter 1 (DMT1) and disturb cellular iron homeostasis.	Iron	124-128	solute carrier family 11 member 2	Homo sapiens	97-101
16103117-0	2005	Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells.	Iron	52-56	hemojuvelin BMP co-receptor	Homo sapiens	15-26
21437029-2	2011	Iron acquisition occurs in the duodenum via divalent metal transporter (DMT1) and ferroportin.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	72-76
16103117-7	2005	In this study, we stably transfected HJV cDNA into human embryonic kidney 293 cells and characterized the processing of HJV and its effect on iron homeostasis.	Iron	142-146	hemojuvelin BMP co-receptor	Homo sapiens	120-123
16103117-12	2005	Immunoblot analysis of ferritin levels and transferrin-55Fe accumulation studies indicated that the HJV-induced increase in intracellular iron levels in human embryonic kidney 293 cells is dependent on the presence of neogenin in the cells, thus linking these two proteins to intracellular iron homeostasis.	Iron	138-142	hemojuvelin BMP co-receptor	Homo sapiens	100-103
16103117-12	2005	Immunoblot analysis of ferritin levels and transferrin-55Fe accumulation studies indicated that the HJV-induced increase in intracellular iron levels in human embryonic kidney 293 cells is dependent on the presence of neogenin in the cells, thus linking these two proteins to intracellular iron homeostasis.	Iron	290-294	hemojuvelin BMP co-receptor	Homo sapiens	100-103
16185064-3	2005	In this work, the time course and products of in vitro NifS-mediated iron-sulfur cluster assembly on full-length NifU and truncated forms involving only the N-terminal domain or the central and C-terminal domains have been investigated using UV-vis absorption and Mossbauer spectroscopies, coupled with analytical studies.	Iron	69-73	NFU1 iron-sulfur cluster scaffold	Homo sapiens	113-117
16185064-7	2005	The assembly and transfer of clusters on NifU are compared with results reported for U- and Nfu-type scaffold proteins, and the need for two functional Fe-S cluster scaffolding domains on NifU is discussed.	Iron	152-156	NFU1 iron-sulfur cluster scaffold	Homo sapiens	188-192
20502350-1	2011	BACKGROUND: The metabolic fates of copper and iron are closely linked through ceruloplasmin and hephaestin.	Iron	46-50	ceruloplasmin	Homo sapiens	78-91
16099526-2	2005	Mutations in the recently described hemojuvelin gene were found in patients with juvenile hemochromatosis, who usually manifest clinical signs of iron overload, including cardiomyopathy and hypogonadism, in their teens and early 20s.	Iron	146-150	hemojuvelin BMP co-receptor	Homo sapiens	36-47
21348612-3	2011	Erythropoiesis is affected by erythropoietin (EPO), an erythropoietic hormone, supplying iron and inflammatory and proinflammatory cytokines.	Iron	89-93	erythropoietin	Rattus norvegicus	30-44
16164630-0	2005	Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy.	Iron	11-15	C-C motif chemokine ligand 2	Homo sapiens	34-39
16164630-3	2005	Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/extrarenal tissues, in plasma, and in the setting of experimental nephropathy.	Iron	44-48	C-C motif chemokine ligand 2	Homo sapiens	111-116
21348612-3	2011	Erythropoiesis is affected by erythropoietin (EPO), an erythropoietic hormone, supplying iron and inflammatory and proinflammatory cytokines.	Iron	89-93	erythropoietin	Rattus norvegicus	46-49
16164630-6	2005	Iron effects on liver, lung, spleen, and heart MCP-1 mRNA, and on peritoneal lavage fluid MCP-1 concentrations were assessed.	Iron	0-4	C-C motif chemokine ligand 2	Homo sapiens	47-52
16164630-7	2005	Iron pretreatment effects on MCP-1 levels in unilaterally obstructed kidneys vs. contralateral kidneys were determined.	Iron	0-4	C-C motif chemokine ligand 2	Homo sapiens	29-34
21394295-6	2011	RESULTS: The up-regulated genes on day 7 by hPDL cells cultured in osteogenic medium were thought to be associated with calcium/iron/metal ion binding or homeostasis (PDE1A, HFE and PCDH9) and cell viability (PCDH9), and the down-regulated genes were thought to be associated with proliferation (PHGDH and PSAT1).	Iron	128-132	protocadherin 9	Homo sapiens	182-187
16164630-18	2005	Finally, iron can increase peritoneal lavage fluid MCP-1 levels.	Iron	9-13	C-C motif chemokine ligand 2	Homo sapiens	51-56
21394295-6	2011	RESULTS: The up-regulated genes on day 7 by hPDL cells cultured in osteogenic medium were thought to be associated with calcium/iron/metal ion binding or homeostasis (PDE1A, HFE and PCDH9) and cell viability (PCDH9), and the down-regulated genes were thought to be associated with proliferation (PHGDH and PSAT1).	Iron	128-132	protocadherin 9	Homo sapiens	209-214
16249618-2	2005	Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide.	Iron	83-87	heme oxygenase 1	Homo sapiens	0-16
16249618-2	2005	Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide.	Iron	83-87	heme oxygenase 1	Homo sapiens	18-22
21215984-2	2011	A decrease of ~ 50% in the ratio of sludge solubilization was found to relate to a high iron content 80-120 mgFe/gSS than that of 4.7-7.4 mgFe/gSS.	Iron	88-92	glutathione synthetase	Homo sapiens	113-116
15821927-2	2005	Ferritin expression was restricted to the endosperm in both lines and protein levels determined by western blot analysis were up to 13-fold higher than in a construct previously reported FK22 (GluB-1/SoyferH-1, in genetically Kitaake background); [corrected] however, the maximum iron concentrations in seeds of both of the new lines were only about 30% higher than FK22.	Iron	280-284	ferritin-1, chloroplastic	Glycine max	0-8
15821927-4	2005	The mean Fe concentration in leaves of ferritin over-expressing lines decreased to less than half of the non-transformant while that the plant biomasses and seed yields of the ferritin-transformed lines were not significantly different from those of the non-transformant, suggesting that accumulation of Fe in seeds of hyper-expression ferritin rice did not always depend on the expression level of exogenous ferritin but may have been limited by Fe uptake and transport.	Iron	9-11	ferritin-1, chloroplastic	Glycine max	39-47
21076043-1	2011	Hepcidin is a major regulator of iron homeostasis, and its expression in liver is regulated by iron, inflammation, and erythropoietic activity with mechanisms that involve bone morphogenetic proteins (BMPs) binding their receptors and coreceptors.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	0-8
16009323-0	2005	Hepcidin: a direct link between iron metabolism and immunity.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
16009323-1	2005	Hepcidin, originally discovered in urine as a bactericidal peptide synthesized by hepatocytes was later proved to be a key regulator of iron metabolism at the whole body level, namely, in conditions of altered iron demand such as the increased or decreased total amount of body iron, inflammation, hypoxia and anemia.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	0-8
21076043-4	2011	Moreover, we observed a strong reduction of serum hepcidin in 5 patients treated with heparin to prevent deep vein thrombosis, which was accompanied by an increase of serum iron and a reduction of C-reactive protein levels.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	50-58
16009323-1	2005	Hepcidin, originally discovered in urine as a bactericidal peptide synthesized by hepatocytes was later proved to be a key regulator of iron metabolism at the whole body level, namely, in conditions of altered iron demand such as the increased or decreased total amount of body iron, inflammation, hypoxia and anemia.	Iron	210-214	hepcidin antimicrobial peptide	Homo sapiens	0-8
16009323-1	2005	Hepcidin, originally discovered in urine as a bactericidal peptide synthesized by hepatocytes was later proved to be a key regulator of iron metabolism at the whole body level, namely, in conditions of altered iron demand such as the increased or decreased total amount of body iron, inflammation, hypoxia and anemia.	Iron	210-214	hepcidin antimicrobial peptide	Homo sapiens	0-8
21029046-0	2011	The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity.	Iron	38-42	glutaredoxin 5	Homo sapiens	31-36
16009323-2	2005	The major mechanism of hepcidin function seems to be the regulation of transmembrane iron transport.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	23-31
16009323-3	2005	Hepcidin binds to its receptor, protein ferroportin, which serves as a transmembrane iron channel enabling iron efflux from cells.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	0-8
16009323-4	2005	The hepcidin-ferroportin complex is then degraded in lysosomes and iron is locked inside the cells (mainly enterocytes, hepatocytes and macrophages).	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	4-12
16009323-6	2005	Utilizing this mechanism, hepcidin regulates serum iron levels during inflammation, infection and possibly also in cancer.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	26-34
16009323-8	2005	In anemia and hypoxia, hepcidin regulates the availability of iron for erythropoiesis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	23-31
15880641-4	2005	Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake.	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	80-84
15880641-4	2005	Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake.	Iron	8-12	solute carrier family 40 member 1	Homo sapiens	101-106
15880641-4	2005	Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake.	Iron	122-126	solute carrier family 11 member 2	Homo sapiens	80-84
21687645-12	2011	Hepcidin is elevated in AML patients pre- and post-HCT due to transfusional iron-loading suggesting that hepcidin synthesis remains intact despite chemotherapy and HCT.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
15880641-4	2005	Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake.	Iron	122-126	solute carrier family 40 member 1	Homo sapiens	101-106
16099050-6	2005	Low serum CC16 concentrations and enhanced Al and iron (Fe) levels were also observed in the younger age group of workers with the subjective CNS symptoms and abnormal VEP results, which suggests that Fe is implicated in strengthening of the neurotoxic Al potential.	Iron	201-203	secretoglobin family 1A member 1	Homo sapiens	10-14
15956071-3	2005	This study evaluated the acute in vivo effect of intravenous iron administration on the oxidation of plasma beta2-microglobulin (beta2m) and on its plasma levels after HD.	Iron	61-65	beta-2-microglobulin	Homo sapiens	108-127
15956071-3	2005	This study evaluated the acute in vivo effect of intravenous iron administration on the oxidation of plasma beta2-microglobulin (beta2m) and on its plasma levels after HD.	Iron	61-65	beta-2-microglobulin	Homo sapiens	129-135
15956071-10	2005	Iron administration also limited the decline in plasma beta2m levels to &lt;7.5%, compared with 27.9+/-2.7% during HD without iron.	Iron	0-4	beta-2-microglobulin	Homo sapiens	55-61
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	145-149	ferric reduction oxidase 3	Arabidopsis thaliana	69-75
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	145-149	ferric reduction oxidase 4	Arabidopsis thaliana	77-83
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	264-268	ferric reduction oxidase 3	Arabidopsis thaliana	69-75
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	264-268	ferric reduction oxidase 4	Arabidopsis thaliana	77-83
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	159-163	ferric reduction oxidase 3	Arabidopsis thaliana	95-101
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	270-274	ferric reduction oxidase 3	Arabidopsis thaliana	95-101
15886332-5	2005	Of the novel phenotypes uncovered, hsp12-Delta and arn1-Delta display increased sensitivity to copper, cyc1-Delta and crr1-Delta show resistance to high copper, vma13-Delta exhibits increased sensitivity to iron deprivation, and pep12-Delta results in reduced growth in high copper and low iron.	Iron	207-211	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	35-40
15886332-5	2005	Of the novel phenotypes uncovered, hsp12-Delta and arn1-Delta display increased sensitivity to copper, cyc1-Delta and crr1-Delta show resistance to high copper, vma13-Delta exhibits increased sensitivity to iron deprivation, and pep12-Delta results in reduced growth in high copper and low iron.	Iron	290-294	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	35-40
16076215-3	2005	Here, we report the characterization of IroD and IroE as esterases for the apo and Fe(3+)-bound forms of Ent, MGE, DGE, and TGE, and we compare their activities with those of Fes, the previously characterized enterobactin esterase.	Iron	175-178	hypothetical protein	Escherichia coli	49-53
16158226-2	2005	Mutations in DMT1 and Ireg1 have revealed that these molecules are major mediators of iron transport across the brush border and basolateral membranes of the enterocyte, respectively.	Iron	86-90	solute carrier family 40 member 1	Homo sapiens	22-27
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	33-37	transferrin receptor 2	Homo sapiens	120-124
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	126-134
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	33-37	hemojuvelin BMP co-receptor	Homo sapiens	139-150
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	transferrin receptor 2	Homo sapiens	120-124
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	126-134
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	hemojuvelin BMP co-receptor	Homo sapiens	139-150
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	transferrin receptor 2	Homo sapiens	120-124
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	126-134
16158226-4	2005	The analysis of a range of human iron loading disorders has provided very strong evidence that the products of the HFE, TfR2, hepcidin and hemojuvelin genes comprise integral components of the machinery that regulates iron absorption and iron traffic around the body.	Iron	218-222	hemojuvelin BMP co-receptor	Homo sapiens	139-150
15986403-0	2005	Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	41-49
15986403-2	2005	Mutations in the gene encoding ferroportin 1, a cellular iron exporter, are responsible for this iron storage disease, inherited as an autosomal dominant trait.	Iron	57-61	solute carrier family 40 member 1	Homo sapiens	31-44
15986403-2	2005	Mutations in the gene encoding ferroportin 1, a cellular iron exporter, are responsible for this iron storage disease, inherited as an autosomal dominant trait.	Iron	97-101	solute carrier family 40 member 1	Homo sapiens	31-44
15986403-10	2005	Finally, macrophage iron storage in ferroportin disease is associated with elevated serum pro-hepcidin levels.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	94-102
16075058-3	2005	Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV intersects with the iron regulatory network has been unclear.	Iron	157-161	hemojuvelin BMP co-receptor	Homo sapiens	69-80
16075058-3	2005	Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV intersects with the iron regulatory network has been unclear.	Iron	157-161	hemojuvelin BMP co-receptor	Homo sapiens	82-85
16075058-3	2005	Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV intersects with the iron regulatory network has been unclear.	Iron	157-161	hemojuvelin BMP co-receptor	Homo sapiens	101-105
16075058-3	2005	Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV intersects with the iron regulatory network has been unclear.	Iron	157-161	hemojuvelin BMP co-receptor	Homo sapiens	110-114
16075059-4	2005	Juvenile hemochromatosis patients have decreased urinary levels of hepcidin, a peptide hormone that binds to the cellular iron exporter ferroportin, causing its internalization and degradation.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	67-75
15749737-0	2005	Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung.	Iron	69-73	solute carrier family 40 member 1	Homo sapiens	19-32
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	0-13
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	15-19
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	25-29
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	42-49
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	142-146	solute carrier family 40 member 1	Homo sapiens	0-13
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	142-146	solute carrier family 40 member 1	Homo sapiens	15-19
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	142-146	solute carrier family 40 member 1	Homo sapiens	25-29
15749737-1	2005	Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron.	Iron	142-146	solute carrier family 40 member 1	Homo sapiens	42-49
15749737-8	2005	Our findings indicate that FPN1, depending on its subcellular location, could have distinct functions in iron homeostasis in different cells and tissues.	Iron	105-109	solute carrier family 40 member 1	Homo sapiens	27-31
15749739-1	2005	Regulation of the metal transport protein divalent metal transporter-1 (DMT1) may contribute to the uptake and detoxification of iron by cells resident in the respiratory tract.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	42-70
15749739-1	2005	Regulation of the metal transport protein divalent metal transporter-1 (DMT1) may contribute to the uptake and detoxification of iron by cells resident in the respiratory tract.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	72-76
15935710-1	2005	The cellular iron exporter ferroportin 1 is expressed in both the duodenum and in cells of the mononuclear phagocyte system.	Iron	13-17	solute carrier family 40 member 1	Homo sapiens	27-40
15935710-5	2005	HFE4 differs from classical hemochromatosis in that there is a greater amount of macrophage iron sequestration.	Iron	92-96	solute carrier family 40 member 1	Homo sapiens	0-4
15935710-8	2005	Others are indistinguishable from native ferroportin 1 and have a similar ability to deplete transfected cells of iron as evidenced by activation of the iron-response proteins and cellular ferritin depletion.	Iron	114-118	solute carrier family 40 member 1	Homo sapiens	41-54
16000726-0	2005	Functions of the siderophore esterases IroD and IroE in iron-salmochelin utilization.	Iron	56-60	hypothetical protein	Escherichia coli	48-52
15737883-3	2005	Hepcidin acts by inhibiting the efflux of iron through ferroportin, the sole known iron exporter of enterocytes, macrophages and hepatocytes.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	0-8
15737883-4	2005	As befits an iron-regulatory hormone, hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	38-46
15737883-5	2005	Hepcidin is markedly induced during infections and inflammation, causing iron to be sequestered in macrophages, hepatocytes and enterocytes.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
15737888-8	2005	In this latter condition, reticuloendothelial iron overload and hyperferritinaemia are caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling.	Iron	46-50	solute carrier family 40 member 1	Homo sapiens	131-138
15737888-8	2005	In this latter condition, reticuloendothelial iron overload and hyperferritinaemia are caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling.	Iron	174-178	solute carrier family 40 member 1	Homo sapiens	131-138
15925529-4	2005	Both mechanisms are linked to an HFE-related hepatic failure in producing hepcidin, a key hormone of body iron regulation.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	74-82
15927501-7	2005	Furthermore, ferroportin seems to be the molecular target of hepcidin, this circulating peptide synthesized by the liver and acting as a negative regulator of intestinal iron absorption and iron recycling by macrophages.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	61-69
15927501-7	2005	Furthermore, ferroportin seems to be the molecular target of hepcidin, this circulating peptide synthesized by the liver and acting as a negative regulator of intestinal iron absorption and iron recycling by macrophages.	Iron	190-194	hepcidin antimicrobial peptide	Homo sapiens	61-69
15898816-6	2005	Acid titration of ferric cyt c in 9 M urea down to pH 2 is accompanied by protonation of one of the axial ligands, water binding to the heme iron (pK(a) = 5.2), and a sudden protein collapse (pH &lt; 4).	Iron	141-145	cytochrome c, somatic	Equus caballus	25-30
15767258-0	2005	Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis.	Iron	85-89	Fe(2+) transporter	Saccharomyces cerevisiae S288C	55-60
15818145-7	2005	Hereditary hemochromatosis is now a complex entity with various clinicopathological forms based on mutations in the HFE gene and other iron-homeostatic genes such as transferrin receptor 2 and ferroportin 1.	Iron	135-139	transferrin receptor 2	Homo sapiens	166-188
15818145-7	2005	Hereditary hemochromatosis is now a complex entity with various clinicopathological forms based on mutations in the HFE gene and other iron-homeostatic genes such as transferrin receptor 2 and ferroportin 1.	Iron	135-139	solute carrier family 40 member 1	Homo sapiens	193-206
15818147-3	2005	For example, the role of hepcidin dysregulation in hemochromatosis has been a surprising discovery that provides some mechanistic understanding for the increased iron absorption that is present in this disorder.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	25-33
21912548-0	2011	Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
15879678-1	2005	Lactoferrin, a member of the transferrin family, is iron-binding and a strongly cationic 76 kDa glycoprotein.	Iron	52-56	lactotransferrin	Bos taurus	0-11
21912548-4	2011	The effects of hypoxia on iron balance have been attributed to hepcidin, a central regulator of iron homeostasis.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	63-71
15753101-0	2005	A putative function for the arabidopsis Fe-Phytosiderophore transporter homolog AtYSL2 in Fe and Zn homeostasis.	Iron	40-42	YELLOW STRIPE like 2	Arabidopsis thaliana	80-86
21912548-4	2011	The effects of hypoxia on iron balance have been attributed to hepcidin, a central regulator of iron homeostasis.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	63-71
15753101-1	2005	Although Arabidopsis thaliana does not produce phytosiderophores (PS) under Fe deficiency, it contains eight homologs of the metal-PS/metal-nicotianamine (NA) transporter ZmYS1 from maize.	Iron	76-78	iron-phytosiderophore transporter yellow stripe 1	Zea mays	171-176
21912548-5	2011	This paper will focus on the molecular mechanisms by which hypoxia affects hepcidin expression, to include a review of the hypoxia inducible factor (HIF)/hypoxia response element (HRE) system, as well as recent evidence indicating that localized adipose hypoxia due to obesity may affect hepcidin signaling and organismal iron metabolism.	Iron	322-326	hepcidin antimicrobial peptide	Homo sapiens	75-83
15753101-3	2005	Northern analysis revealed high expression levels of AtYSL2 in Fe-sufficient or Fe-resupplied roots, while under Fe deficiency transcript levels decreased.	Iron	63-65	YELLOW STRIPE like 2	Arabidopsis thaliana	53-59
15753101-3	2005	Northern analysis revealed high expression levels of AtYSL2 in Fe-sufficient or Fe-resupplied roots, while under Fe deficiency transcript levels decreased.	Iron	80-82	YELLOW STRIPE like 2	Arabidopsis thaliana	53-59
22162689-0	2011	Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development.	Iron	42-46	heme oxygenase 1	Homo sapiens	0-16
15753101-3	2005	Northern analysis revealed high expression levels of AtYSL2 in Fe-sufficient or Fe-resupplied roots, while under Fe deficiency transcript levels decreased.	Iron	80-82	YELLOW STRIPE like 2	Arabidopsis thaliana	53-59
15753101-4	2005	Quantitative real-time polymerase chain reaction (PCR) and analysis of transgenic plants expressing an AtYSL2 promoter::beta-glucuronidase gene further allowed the detection of down-regulated AtYSL2 gene expression under Zn and Fe deficiency.	Iron	228-230	YELLOW STRIPE like 2	Arabidopsis thaliana	103-109
15753101-4	2005	Quantitative real-time polymerase chain reaction (PCR) and analysis of transgenic plants expressing an AtYSL2 promoter::beta-glucuronidase gene further allowed the detection of down-regulated AtYSL2 gene expression under Zn and Fe deficiency.	Iron	228-230	YELLOW STRIPE like 2	Arabidopsis thaliana	192-198
22162689-4	2011	Null mutation of Hmox1 results in significant embryonic mortality as well as anemia and defective iron recycling.	Iron	98-102	heme oxygenase 1	Homo sapiens	17-22
15839648-1	2005	The physiological electron-transfer (ET) partners, cytochrome c peroxidase (CcP) and cytochrome c (Cc)1, can be modified to exhibit photoinitiated ET through substitution of Zn (or Mg) for Fe in either partner.	Iron	189-191	C-C motif chemokine ligand 14	Homo sapiens	85-103
20624491-2	2011	CPR shuttles electrons from NADPH through the FAD and FMN-coenzymes into the iron of the prosthetic heme-group of the CYP.	Iron	77-81	peptidylprolyl isomerase G	Homo sapiens	118-121
15878745-11	2005	Whilst the consequence of altered DMT1 expression on renal iron handling and oxidant damage remains to be determined, the attenuation of the putative lysosomal iron exit pathway in proximal tubules could potentially explain lysosomal iron accumulation reported in human diabetes and STZ-diabetic animals.	Iron	59-63	solute carrier family 11 member 2	Homo sapiens	34-38
21829013-8	2011	RESULTS: The discovery of hepcidin as the major controller of iron metabolism in anemia of inflammation answered many questions regarding the interaction of erythropoietin, iron and bone marrow.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	26-34
15550525-8	2005	These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1.	Iron	40-44	C-C motif chemokine ligand 2	Rattus norvegicus	223-257
15550525-8	2005	These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1.	Iron	53-57	C-C motif chemokine ligand 2	Rattus norvegicus	223-257
15833036-7	2005	If operative in vivo, this reaction would impair the antioxidant role of CP and iron uptake by ferritin and hence contribute to intracellular iron-induced oxidative stress during AA accumulation in diabetes mellitus.	Iron	142-146	ceruloplasmin	Homo sapiens	73-75
21829013-8	2011	RESULTS: The discovery of hepcidin as the major controller of iron metabolism in anemia of inflammation answered many questions regarding the interaction of erythropoietin, iron and bone marrow.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	26-34
21829013-9	2011	Hepcidin production in the liver is driven by three major factors: inflammation, iron overload and anemia/hypoxia.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
21239856-1	2011	The amyloid-beta protein (Abeta) is a metalloprotein with affinity for the metal ions zinc (Zn), copper (Cu), and iron (Fe), which are found in high concentrations in the plaques of Alzheimer"s disease (AD).	Iron	114-118	amyloid beta (A4) precursor protein	Mus musculus	26-31
15844705-7	2005	Systemic iron supplementation for 16 weeks replenished splenic iron in a spontaneous colitis model (interleukin-2-deficient mice) and significantly reduced colonic inflammation compared to interleukin-2 (-/-) controls without increasing hyperplastic lesions.	Iron	9-13	interleukin 2	Mus musculus	100-113
15844705-7	2005	Systemic iron supplementation for 16 weeks replenished splenic iron in a spontaneous colitis model (interleukin-2-deficient mice) and significantly reduced colonic inflammation compared to interleukin-2 (-/-) controls without increasing hyperplastic lesions.	Iron	9-13	interleukin 2	Mus musculus	189-202
21239856-1	2011	The amyloid-beta protein (Abeta) is a metalloprotein with affinity for the metal ions zinc (Zn), copper (Cu), and iron (Fe), which are found in high concentrations in the plaques of Alzheimer"s disease (AD).	Iron	120-122	amyloid beta (A4) precursor protein	Mus musculus	26-31
15468060-0	2005	Iron specific growth inhibition of Burkitt"s lymphoma cells in vitro, associated with a decrease in translocated c-myc expression.	Iron	0-4	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	113-118
15468060-5	2005	It has been reported that iron can increase cell proliferation, mainly by stimulating DNA synthesis as well as by enhancing c-myc expression.	Iron	26-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-129
22348199-2	2011	Recent evidence points to hepcidin, the key regulator of macrophage iron uptake and release, as a potential mediator of risk.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	26-34
15468060-6	2005	Here, we studied the effect of iron on cells in which c-myc expression is deregulated by either chromosomal translocation or gene amplification.	Iron	31-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	54-59
15468060-10	2005	Collectively, our results suggest the existence of a novel iron-dependent cell cycle regulatory mechanism involving modulation of translocated c-myc gene expression.	Iron	59-63	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	143-148
20932599-1	2011	The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and related disorders, the results of which have profoundly changed our view of human diseases associated with excess of iron, iron deficiency or iron misdistribution.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	17-25
16849170-3	2005	His-26 and His-33 are both solvent exposed, and the results suggest that one of these histidine residues acts as a bridge in the electron transfer to and from the haem iron of cytochrome c.	Iron	168-172	cytochrome c, somatic	Equus caballus	176-188
20932599-1	2011	The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and related disorders, the results of which have profoundly changed our view of human diseases associated with excess of iron, iron deficiency or iron misdistribution.	Iron	211-215	hepcidin antimicrobial peptide	Homo sapiens	17-25
15747401-1	2005	New insights into cellular iron metabolism have been provided by the recognition that certain diseases are associated with mitochondrial iron overload and by the discovery of mitochondrial ferritin (MtFt) and mitochondrial iron transporters.	Iron	27-31	ferritin mitochondrial	Homo sapiens	175-197
20932599-1	2011	The discovery of hepcidin has triggered a virtual explosion of studies on iron metabolism and related disorders, the results of which have profoundly changed our view of human diseases associated with excess of iron, iron deficiency or iron misdistribution.	Iron	211-215	hepcidin antimicrobial peptide	Homo sapiens	17-25
15747401-1	2005	New insights into cellular iron metabolism have been provided by the recognition that certain diseases are associated with mitochondrial iron overload and by the discovery of mitochondrial ferritin (MtFt) and mitochondrial iron transporters.	Iron	27-31	ferritin mitochondrial	Homo sapiens	199-203
20932599-3	2011	The notion that hepcidin excess or deficiency may contribute to the dysregulation of iron homeostasis in hereditary and acquired iron disorders raises the possibility that hepcidin-lowering or enhancing agents may be an effective strategy for curing the main consequences of hepcidinopathies, anemia or iron overload, respectively.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	16-24
22167735-5	2011	On the other hand, much knowledge regarding iron metabolism has been gained since the description of the regulatory hormone, hepcidin.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	125-133
15711214-4	2005	RECENT FINDINGS: The hepatic peptide hepcidin plays a key role as a circulating hormone that regulates the absorption of dietary iron from the duodenum.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	37-45
15711214-6	2005	Other hepatic proteins essential for normal iron homeostasis, including HFE, transferrin receptor 2 (TfR2), and hemojuvelin, function at least in part, by modulating the expression of hepcidin.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	184-192
15718100-0	2005	Positional cloning of the Ttc7 gene required for normal iron homeostasis and mutated in hea and fsn anemia mice.	Iron	56-60	tetratricopeptide repeat domain 7	Mus musculus	26-30
15718100-2	2005	We report the discovery of a strong candidate gene affecting iron homeostasis in two allelic anemia mouse mutants: hea (hereditary erythroblastic anemia) and fsn (flaky skin).	Iron	61-65	tetratricopeptide repeat domain 7	Mus musculus	115-118
15718100-2	2005	We report the discovery of a strong candidate gene affecting iron homeostasis in two allelic anemia mouse mutants: hea (hereditary erythroblastic anemia) and fsn (flaky skin).	Iron	61-65	tetratricopeptide repeat domain 7	Mus musculus	158-161
15718100-7	2005	We speculate that TTC7 plays an important role in iron transport.	Iron	50-54	tetratricopeptide repeat domain 7	Mus musculus	18-22
22096640-3	2011	Evidence for abnormal iron homeostasis in MS comes also from analyses of iron and iron-related proteins in CSF and blood and postmortem MS brain sections.	Iron	73-77	colony stimulating factor 2	Homo sapiens	107-110
15726660-1	2005	Hepcidin, the iron hormone, is produced by the liver in response to iron and inflammation.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	0-8
15726660-1	2005	Hepcidin, the iron hormone, is produced by the liver in response to iron and inflammation.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
22096640-3	2011	Evidence for abnormal iron homeostasis in MS comes also from analyses of iron and iron-related proteins in CSF and blood and postmortem MS brain sections.	Iron	73-77	colony stimulating factor 2	Homo sapiens	107-110
15726660-7	2005	Also, iron overload markedly upregulated hepatic hepcidin mRNA, but this activity persisted in spite of Kupffer cell blockade.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	49-57
21146130-1	2011	OBJECTIVE: To evaluate the transepithelial transport of sodium, glucose, potassium, and water and the mRNA level of the sodium-glucose cotransporter (SGLT1) and the facilitated sugar transporter (GLUT2) in the small intestine of iron-deficient rats.	Iron	229-233	solute carrier family 2 member 2	Rattus norvegicus	196-201
21176807-4	2011	Hepcidin is an iron regulatory hormone that inhibits ferroportin-mediated iron export from enterocytes and macrophages.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
21886780-2	2011	Beyond red blood cells transfusions, dysregulation of hepcidin, the key iron hormone, may play a role, but studies until now have been hampered by technical problems.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	54-62
21886780-6	2011	Consistently with current knowledge on hepcidin action/regulation, RARS patients had the highest levels of toxic non-transferrin-bound-iron, while RAEB and CMML patients had substantial elevation of C-Reactive Protein as compared to other MDS subtypes, and showed lost of homeostatic regulation by iron.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	39-47
21886780-6	2011	Consistently with current knowledge on hepcidin action/regulation, RARS patients had the highest levels of toxic non-transferrin-bound-iron, while RAEB and CMML patients had substantial elevation of C-Reactive Protein as compared to other MDS subtypes, and showed lost of homeostatic regulation by iron.	Iron	298-302	hepcidin antimicrobial peptide	Homo sapiens	39-47
21633699-3	2011	We have recently reported that oligodendrocytes (OLs) are the type of cells in the brain that are most susceptible to lack of Hx, as the number of iron-overloaded OLs increases in Hx-null brain, leading to oxidative tissue damage.	Iron	147-151	hemopexin	Mus musculus	180-182
21751515-1	2011	UNLABELLED: Hepcidin is a newly discovered iron metabolism regulator.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	12-20
22440657-3	2011	OBJECTIVE: To evaluate the ability of Reticulocyte Hemoglobin Equivalent (RET-He) to predict iron deficiency, taking as a reference standard to the increase of hemoglobin in response to iron intake.	Iron	93-97	ret proto-oncogene	Homo sapiens	74-77
22440657-10	2011	CONCLUSIONS: According to these results it could consider to Ret-He and the Ret-He/IST combination of clinical utility for the identification of the iron deficit in patients in chronic haemodialysis.	Iron	149-153	ret proto-oncogene	Homo sapiens	61-64
22440657-10	2011	CONCLUSIONS: According to these results it could consider to Ret-He and the Ret-He/IST combination of clinical utility for the identification of the iron deficit in patients in chronic haemodialysis.	Iron	149-153	ret proto-oncogene	Homo sapiens	76-79
20950636-7	2011	ATO, on the other hand, induced heme oxygenase-1 (HO-1) to catalyze heme degradation, thereby provided ferrous iron for EGCG-induced hydrogen peroxide to precede Fenton reaction, which in turn generated deleterious reactive oxygen species to damage cell.	Iron	111-115	heme oxygenase 1	Homo sapiens	32-48
20950636-7	2011	ATO, on the other hand, induced heme oxygenase-1 (HO-1) to catalyze heme degradation, thereby provided ferrous iron for EGCG-induced hydrogen peroxide to precede Fenton reaction, which in turn generated deleterious reactive oxygen species to damage cell.	Iron	111-115	heme oxygenase 1	Homo sapiens	50-54
20929442-0	2010	Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster.	Iron	99-103	transcriptional regulator WhiB1	Mycobacterium tuberculosis H37Rv	27-32
20863724-5	2010	In this study we investigated whether also in humans the expression of BMP signaling targets, SMAD7 and Id1, are associated with liver iron concentration (LIC) and whether such regulation is disrupted in HFE-HC.	Iron	135-139	bone morphogenetic protein 1	Homo sapiens	71-74
20724023-5	2010	Transcript correlation analysis highlighted a partial inverse relationship between the transcript levels of the mitochondrial ferric reductase oxidase FRO3, putatively involved in mitochondrial iron import/export, and AtFer4.	Iron	194-198	ferric reduction oxidase 3	Arabidopsis thaliana	151-155
20937842-1	2010	Hemojuvelin (HJV) is an important regulator of iron metabolism.	Iron	47-51	hemojuvelin BMP co-receptor	Homo sapiens	0-11
20937842-1	2010	Hemojuvelin (HJV) is an important regulator of iron metabolism.	Iron	47-51	hemojuvelin BMP co-receptor	Homo sapiens	13-16
21143959-1	2010	BACKGROUND: Hepcidin acts as the main regulator of iron homeostasis through regulation of intestinal absorption and macrophage release.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	12-20
21143959-2	2010	Hepcidin deficiency causes iron overload whereas its overproduction is associated with anaemia of chronic diseases.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
21143959-3	2010	The aims of the study were: to identify genetic variants in the hepcidin gene (HAMP) promoter, to asses the associations between the variants found and iron status parameters, and to functionally study the role on HAMP expression of the most frequent variant.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	64-72
21143959-4	2010	RESULTS: The sequencing of HAMP promoter from 103 healthy individuals revealed two genetic variants: The c.-153C &gt; T with a frequency of 0.014 for allele T, which is known to reduce hepcidin expression and the c.-582A &gt; G with a 0.218 frequency for allele G. In an additional group of 224 individuals, the c.-582A &gt; G variant genotype showed no association with serum iron, transferrin or ferritin levels.The c.-582G HAMP promoter variant decreased the transcriptional activity by 20% compared to c.-582A variant in cells from the human hepatoma cell line HepG2 when cotransfected with luciferase reporter constructs and plasmid expressing upstream stimulatory factor 1 (USF1) and by 12-14% when cotransfected with plasmid expressing upstream stimulatory factor 2 (USF2).	Iron	377-381	hepcidin antimicrobial peptide	Homo sapiens	27-31
21143959-4	2010	RESULTS: The sequencing of HAMP promoter from 103 healthy individuals revealed two genetic variants: The c.-153C &gt; T with a frequency of 0.014 for allele T, which is known to reduce hepcidin expression and the c.-582A &gt; G with a 0.218 frequency for allele G. In an additional group of 224 individuals, the c.-582A &gt; G variant genotype showed no association with serum iron, transferrin or ferritin levels.The c.-582G HAMP promoter variant decreased the transcriptional activity by 20% compared to c.-582A variant in cells from the human hepatoma cell line HepG2 when cotransfected with luciferase reporter constructs and plasmid expressing upstream stimulatory factor 1 (USF1) and by 12-14% when cotransfected with plasmid expressing upstream stimulatory factor 2 (USF2).	Iron	377-381	hepcidin antimicrobial peptide	Homo sapiens	185-193
21126372-1	2010	BACKGROUND: Physiological regulation of cellular iron involves iron export by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	184-192
21126372-1	2010	BACKGROUND: Physiological regulation of cellular iron involves iron export by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	184-192
21126372-1	2010	BACKGROUND: Physiological regulation of cellular iron involves iron export by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	184-192
21126372-6	2010	Furthermore, exposure of promonocytic THP-1 cells to hepcidin was associated with decreased ferroportin expression, increased intracellular iron and induction of reporter luciferase gene expression.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	53-61
20926522-10	2010	CONCLUSIONS: Dietary iron absorption is reduced by   40% in asymptomatic P. falciparum parasitemia, likely because of low-grade inflammation and its modulation of circulating hepcidin.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	175-183
20880062-5	2010	RESULTS:   In patients with NAFLD, expression of HJV, TfR2, FPN, TfR1, FtH, SOD and catalase was increased, compared with that in N. In addition, hepatic iron content, which was increased in NASH, was correlated with expression level of TfR2.	Iron	154-158	hemojuvelin BMP co-receptor	Homo sapiens	49-52
20880062-5	2010	RESULTS:   In patients with NAFLD, expression of HJV, TfR2, FPN, TfR1, FtH, SOD and catalase was increased, compared with that in N. In addition, hepatic iron content, which was increased in NASH, was correlated with expression level of TfR2.	Iron	154-158	transferrin receptor 2	Homo sapiens	237-241
20880062-7	2010	CONCLUSION:   The results of the present study suggest that the reasons responsible for iron accumulation in NASH in the present study may partly be due to enhanced expression of TfRs, especially TfR2, and hyperdynamic state of retinoid metabolism is closely related to iron metabolism in the disease.	Iron	88-92	transferrin receptor 2	Homo sapiens	196-200
21075282-0	2010	Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in beta-thalassemia.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	40-48
21075282-0	2010	Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in beta-thalassemia.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	40-48
21075282-4	2010	Particular attention is paid to the pathway(s) controlling the expression of hepcidin, which is the main regulator of iron metabolism, and the Epo/EpoR/Jak2/Stat5 signaling pathway, which regulates erythropoiesis.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	77-85
21088898-7	2010	Subsequent molecular characterization of the ETFDH gene revealed novel heterozygous mutations, p.G274X:c.820 G &gt; T (exon 7) and p.P534L: c.1601 C &gt; T (exon 12), the latter within the iron sulfur-cluster and predicted to affect ubiquinone reductase activity of ETFDH and the docking of ETF to ETFDH.	Iron	189-193	TEA domain transcription factor 2	Homo sapiens	45-48
20730621-8	2010	The increased level of oxidative stress in AD brain is reflected by the increased brain content of iron (Fe) and copper (Cu) both capable of stimulating free radical formation (e.g. hydroxyl radicals via Fenton reaction), increased protein and DNA oxidation in the AD brain, enhanced lipid peroxidation, decreased level of cytochrome c oxidase and advanced glycation end products (AGEs), carbonyls, malondialdehyde (MDA), peroxynitrite, and heme oxygenase-1 (HO-1).	Iron	105-107	heme oxygenase 1	Homo sapiens	459-463
20538788-1	2010	BACKGROUND: It has been suggested that hepcidin may be useful as a tool for managing iron therapy in haemodialysis (HD) patients on erythropoiesis-stimulating agents (ESA).	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	39-47
15683854-2	2005	Lactoferrin, an iron-binding protein with immune regulatory functions, was investigated as an adjuvant to boost Mycobacterium bovis Bacillus Calmette-Guerin (BCG) efficacy.	Iron	16-20	lactotransferrin	Mus musculus	0-11
20538788-7	2010	CONCLUSIONS: Although our study suggests an important role for hepcidin in regulating iron homeostasis in HD patients on ESA, our findings do not support its utility as a predictor of iron needs, offering no advantage over established markers of iron status.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	63-71
15611066-8	2005	However, in contrast to prokaryotic SufB proteins with no associated ATPase activity we show that AtNAP1 is an iron-stimulated ATPase and that AtNAP1 is capable of forming homodimers.	Iron	111-115	transcription activator	Arabidopsis thaliana	98-104
21348241-3	2010	The central player regulating the amount of iron in the body is hepcidin.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	64-72
15611066-9	2005	Our results suggest that AtNAP1 represents an atypical plastidic SufB-like protein important for Fe-S cluster assembly and for regulating iron homeostasis in Arabidopsis.	Iron	138-142	transcription activator	Arabidopsis thaliana	25-31
15710580-0	2005	Hemojuvelin (HJV)-associated hemochromatosis: analysis of HJV and HFE mutations and iron overload in three families.	Iron	84-88	hemojuvelin BMP co-receptor	Homo sapiens	0-11
21348241-4	2010	Hepcidin inhibits the release of iron from enterocytes and macrophages by accelerating the degradation of ferroportin, which is an exporter of iron.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
21348241-4	2010	Hepcidin inhibits the release of iron from enterocytes and macrophages by accelerating the degradation of ferroportin, which is an exporter of iron.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	0-8
20688429-1	2010	This study investigates the impact of the type of virgin granular activated carbon (GAC) media used to synthesize iron (hydr)oxide nanoparticle-impregnated granular activated carbon (Fe-GAC) on its properties and its ability to remove arsenate and organic trichloroethylene (TCE) from water.	Iron	183-185	glutaminase	Homo sapiens	84-87
15533837-5	2005	The percentage of tandem CC --&gt; TT substitutions rose to 64% and 94% for Pms2-deficient cells exposed to UV and a mixture of hydrogen peroxide and metals (Cu/Fe), respectively.	Iron	161-163	PMS1 homolog 2, mismatch repair system component	Homo sapiens	76-80
16339659-5	2005	In another recent observation, the iron in ferritin from seeds such as soybeans has been shown to be readily available to tissues with high demand for iron, such as red blood cells, but slower to be mobilized in other tissues, compared to nonheme iron salts, presumably through a controlled iron gating mechanism.	Iron	151-155	ferritin-1, chloroplastic	Glycine max	43-51
16339659-6	2005	Because the iron pore gating property of ferritin is more thoroughly investigated, and the knowledge that much of the iron to be chelated in the thalassemias is from a solid iron mineral inside the ferritin protein nanocage, a new role of ferritin in regulating cellular iron homeostasis is established.	Iron	12-16	ferritin-1, chloroplastic	Glycine max	41-49
16339659-6	2005	Because the iron pore gating property of ferritin is more thoroughly investigated, and the knowledge that much of the iron to be chelated in the thalassemias is from a solid iron mineral inside the ferritin protein nanocage, a new role of ferritin in regulating cellular iron homeostasis is established.	Iron	118-122	ferritin-1, chloroplastic	Glycine max	198-206
16339659-6	2005	Because the iron pore gating property of ferritin is more thoroughly investigated, and the knowledge that much of the iron to be chelated in the thalassemias is from a solid iron mineral inside the ferritin protein nanocage, a new role of ferritin in regulating cellular iron homeostasis is established.	Iron	118-122	ferritin-1, chloroplastic	Glycine max	198-206
20688429-1	2010	This study investigates the impact of the type of virgin granular activated carbon (GAC) media used to synthesize iron (hydr)oxide nanoparticle-impregnated granular activated carbon (Fe-GAC) on its properties and its ability to remove arsenate and organic trichloroethylene (TCE) from water.	Iron	183-185	glutaminase	Homo sapiens	186-189
16339659-6	2005	Because the iron pore gating property of ferritin is more thoroughly investigated, and the knowledge that much of the iron to be chelated in the thalassemias is from a solid iron mineral inside the ferritin protein nanocage, a new role of ferritin in regulating cellular iron homeostasis is established.	Iron	118-122	ferritin-1, chloroplastic	Glycine max	198-206
16339659-6	2005	Because the iron pore gating property of ferritin is more thoroughly investigated, and the knowledge that much of the iron to be chelated in the thalassemias is from a solid iron mineral inside the ferritin protein nanocage, a new role of ferritin in regulating cellular iron homeostasis is established.	Iron	118-122	ferritin-1, chloroplastic	Glycine max	198-206
16339659-6	2005	Because the iron pore gating property of ferritin is more thoroughly investigated, and the knowledge that much of the iron to be chelated in the thalassemias is from a solid iron mineral inside the ferritin protein nanocage, a new role of ferritin in regulating cellular iron homeostasis is established.	Iron	118-122	ferritin-1, chloroplastic	Glycine max	198-206
20688429-2	2010	Two Fe-GAC media were synthesized via a permanganate/ferrous ion synthesis method using bituminous and lignite-based virgin GAC.	Iron	4-6	glutaminase	Homo sapiens	7-10
16339659-6	2005	Because the iron pore gating property of ferritin is more thoroughly investigated, and the knowledge that much of the iron to be chelated in the thalassemias is from a solid iron mineral inside the ferritin protein nanocage, a new role of ferritin in regulating cellular iron homeostasis is established.	Iron	118-122	ferritin-1, chloroplastic	Glycine max	198-206
16339659-7	2005	Two new areas, based on recent knowledge of the molecular properties of ferritin, are (1) exploration of food ferritin as a potentially safer form of dietary nonheme iron, and (2) development of chelators targeted to ferritin protein pores that control chelator access.	Iron	166-170	ferritin-1, chloroplastic	Glycine max	72-80
20688429-2	2010	Two Fe-GAC media were synthesized via a permanganate/ferrous ion synthesis method using bituminous and lignite-based virgin GAC.	Iron	4-6	glutaminase	Homo sapiens	124-127
20688429-4	2010	in correlation with batch equilibrium tests, and continuous flow modeling suggested that GAC type and pore size distribution control the iron (nanoparticle) contents, Fe-GAC synthesis mechanisms, and contaminant removal performances.	Iron	137-141	glutaminase	Homo sapiens	89-92
20688429-4	2010	in correlation with batch equilibrium tests, and continuous flow modeling suggested that GAC type and pore size distribution control the iron (nanoparticle) contents, Fe-GAC synthesis mechanisms, and contaminant removal performances.	Iron	167-169	glutaminase	Homo sapiens	89-92
16232085-10	2005	Correlations of biochemical iron markers with RET-H(e) were as weak as with CHr in patients with ACD and acute phase response.	Iron	28-32	ret proto-oncogene	Homo sapiens	46-49
20688429-4	2010	in correlation with batch equilibrium tests, and continuous flow modeling suggested that GAC type and pore size distribution control the iron (nanoparticle) contents, Fe-GAC synthesis mechanisms, and contaminant removal performances.	Iron	167-169	glutaminase	Homo sapiens	170-173
16232085-11	2005	In a diagnostic plot to identify iron status, RET-H(e) could replace CHr without any loss of sensitivity or specificity.	Iron	33-37	ret proto-oncogene	Homo sapiens	46-49
16232085-15	2005	RET-H(e) is as valuable as CHr for the diagnosis of iron-restricted erythropoiesis.	Iron	52-56	ret proto-oncogene	Homo sapiens	0-3
20932062-6	2010	Disruption of the three-dimensional structure of mitoNEET(44-108) as a result of decomposition of the iron-sulfur clusters was observed by NMR and circular dichroism experiments.	Iron	102-106	CDGSH iron sulfur domain 1	Homo sapiens	49-57
16232085-16	2005	The combination of RET-H(e) and the sTfR-F index in a diagnostic plot offers an attractive tool for the evaluation of iron status and identification of the progression of ID.	Iron	118-122	ret proto-oncogene	Homo sapiens	19-22
20702690-6	2010	Immunoblot experiments demonstrated a &gt;60-fold increase in HIF2alpha protein abundance in iron-deprived cells; HIF1alpha levels were unchanged.	Iron	93-97	endothelial PAS domain protein 1	Homo sapiens	62-71
16103673-0	2005	Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	29-37
16103673-1	2005	BACKGROUND/AIMS: In HFE-related hereditary hemochromatosis an inappropriately low hepatic expression of the iron-regulatory peptide hepcidin (encoded by HAMP) has been suggested to cause iron overload.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	132-140
16103673-1	2005	BACKGROUND/AIMS: In HFE-related hereditary hemochromatosis an inappropriately low hepatic expression of the iron-regulatory peptide hepcidin (encoded by HAMP) has been suggested to cause iron overload.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	153-157
16103673-1	2005	BACKGROUND/AIMS: In HFE-related hereditary hemochromatosis an inappropriately low hepatic expression of the iron-regulatory peptide hepcidin (encoded by HAMP) has been suggested to cause iron overload.	Iron	187-191	hepcidin antimicrobial peptide	Homo sapiens	132-140
16103673-1	2005	BACKGROUND/AIMS: In HFE-related hereditary hemochromatosis an inappropriately low hepatic expression of the iron-regulatory peptide hepcidin (encoded by HAMP) has been suggested to cause iron overload.	Iron	187-191	hepcidin antimicrobial peptide	Homo sapiens	153-157
16103673-2	2005	The aim of the present study was to evaluate whether the hepatic expression of HAMP in relation to iron stores requires HFE or might involve other important iron-related genes including HJV (encoding hemojuvelin) and TFR2 (encoding transferrin receptor-2).	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	79-83
16103673-2	2005	The aim of the present study was to evaluate whether the hepatic expression of HAMP in relation to iron stores requires HFE or might involve other important iron-related genes including HJV (encoding hemojuvelin) and TFR2 (encoding transferrin receptor-2).	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	79-83
16103673-3	2005	METHODS: Using quantitative RT-PCR, the iron-dependent hepatic expression patterns of HAMP, HJV, and TFR2 were evaluated in human and murine HFE-related hemochromatosis.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	86-90
16103673-3	2005	METHODS: Using quantitative RT-PCR, the iron-dependent hepatic expression patterns of HAMP, HJV, and TFR2 were evaluated in human and murine HFE-related hemochromatosis.	Iron	40-44	hemojuvelin BMP co-receptor	Homo sapiens	92-95
16103673-3	2005	METHODS: Using quantitative RT-PCR, the iron-dependent hepatic expression patterns of HAMP, HJV, and TFR2 were evaluated in human and murine HFE-related hemochromatosis.	Iron	40-44	transferrin receptor 2	Homo sapiens	101-105
16103673-4	2005	RESULTS: The overall level of hepatic HAMP expression in human and murine HFE-related hemochromatosis is impaired but can still be modulated by iron stores.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	38-42
20655381-1	2010	Ceruloplasmin plays an essential role in cellular iron efflux by oxidizing ferrous iron exported from ferroportin.	Iron	50-54	ceruloplasmin	Homo sapiens	0-13
16103673-8	2005	An HFE-independent pathway that seems to involve TFR2 and HJV can regulate HAMP expression under conditions of iron overload.	Iron	111-115	transferrin receptor 2	Homo sapiens	49-53
16103673-8	2005	An HFE-independent pathway that seems to involve TFR2 and HJV can regulate HAMP expression under conditions of iron overload.	Iron	111-115	hemojuvelin BMP co-receptor	Homo sapiens	58-61
16103673-8	2005	An HFE-independent pathway that seems to involve TFR2 and HJV can regulate HAMP expression under conditions of iron overload.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	75-79
20655381-1	2010	Ceruloplasmin plays an essential role in cellular iron efflux by oxidizing ferrous iron exported from ferroportin.	Iron	83-87	ceruloplasmin	Homo sapiens	0-13
20655381-6	2010	A decrease in the extracellular ferrous iron by an iron chelator and incubation with purified ceruloplasmin in the culture medium prevented hepcidin-mediated ferroportin internalization, while the reconstitution of apo-ceruloplasmin was not able to prevent ferroportin internalization.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	140-148
15599216-0	2005	Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. PURPOSE: Liver iron is frequently elevated in chronic hepatitis C and may contribute to liver injury.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	6-14
20655381-6	2010	A decrease in the extracellular ferrous iron by an iron chelator and incubation with purified ceruloplasmin in the culture medium prevented hepcidin-mediated ferroportin internalization, while the reconstitution of apo-ceruloplasmin was not able to prevent ferroportin internalization.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	140-148
15599216-0	2005	Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. PURPOSE: Liver iron is frequently elevated in chronic hepatitis C and may contribute to liver injury.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	6-14
15599216-1	2005	The pathophysiology behind this phenomenon may involve hepcidin, a gene that is up-regulated in the liver by inflammation and iron.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	55-63
20704562-1	2010	IRIDA (iron-refractory iron-deficiency anaemia) is a rare autosomal-recessive disorder hallmarked by hypochromic microcytic anaemia, low transferrin saturation and high levels of the iron-regulated hormone hepcidin.	Iron	7-11	hepcidin antimicrobial peptide	Homo sapiens	206-214
15599216-6	2005	RESULTS: Among patients with hepatitis C, there was a significant correlation of hepcidin mRNA expression in the liver with hepatic iron concentration and serum ferritin (r = 0.72, P = 0.006, and r = 0.60, P = 0.01, respectively).	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	81-89
15599216-9	2005	CONCLUSION: In contrast to other inflammatory states, hepcidin mRNA expression in the liver was independent of markers of inflammation in hepatitis C. Instead, our results suggest that iron stores in patients with hepatitis C regulate hepcidin expression and that iron loading in chronic hepatitis C is not due to inappropriate hepcidin expression.	Iron	185-189	hepcidin antimicrobial peptide	Homo sapiens	54-62
15599216-9	2005	CONCLUSION: In contrast to other inflammatory states, hepcidin mRNA expression in the liver was independent of markers of inflammation in hepatitis C. Instead, our results suggest that iron stores in patients with hepatitis C regulate hepcidin expression and that iron loading in chronic hepatitis C is not due to inappropriate hepcidin expression.	Iron	185-189	hepcidin antimicrobial peptide	Homo sapiens	235-243
15599216-9	2005	CONCLUSION: In contrast to other inflammatory states, hepcidin mRNA expression in the liver was independent of markers of inflammation in hepatitis C. Instead, our results suggest that iron stores in patients with hepatitis C regulate hepcidin expression and that iron loading in chronic hepatitis C is not due to inappropriate hepcidin expression.	Iron	185-189	hepcidin antimicrobial peptide	Homo sapiens	235-243
15599216-9	2005	CONCLUSION: In contrast to other inflammatory states, hepcidin mRNA expression in the liver was independent of markers of inflammation in hepatitis C. Instead, our results suggest that iron stores in patients with hepatitis C regulate hepcidin expression and that iron loading in chronic hepatitis C is not due to inappropriate hepcidin expression.	Iron	264-268	hepcidin antimicrobial peptide	Homo sapiens	54-62
20704562-1	2010	IRIDA (iron-refractory iron-deficiency anaemia) is a rare autosomal-recessive disorder hallmarked by hypochromic microcytic anaemia, low transferrin saturation and high levels of the iron-regulated hormone hepcidin.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	206-214
20456882-8	2010	We found a positive correlation between the serum level of Fe at 1month of age and PDI score at 18months of age.	Iron	59-61	peptidyl arginine deiminase 1	Homo sapiens	83-86
15935835-0	2005	Iron-mediated stability of PAI-1 mRNA in adenocarcinoma cells-involvement of a mRNA-binding nuclear protein.	Iron	0-4	serpin family E member 1	Homo sapiens	27-32
15935835-1	2005	This study reports the stability of mRNA of type-1 plasminogen activator inhibitor (PAI-1), the major physiologic inhibitor of plasminogen activation, by deferoxamine-aided iron deprivation, in PC3 adenocarcinoma cells.	Iron	173-177	serpin family E member 1	Homo sapiens	84-89
15935835-3	2005	Co-treatment with ferric citrate quenched the effect of deferoxamine, confirming the role of iron in PAI-1 regulation.	Iron	93-97	serpin family E member 1	Homo sapiens	101-106
15935835-6	2005	Electrophoretic mobility shift assay revealed the presence of a nuclear protein, binding to the 3"-UTR of PAI-1 mRNA in an iron-mediated manner.	Iron	123-127	serpin family E member 1	Homo sapiens	106-111
15935835-7	2005	This is the first report of iron-mediated mRNA-protein interaction in PAI-1, involved in mRNA stability.	Iron	28-32	serpin family E member 1	Homo sapiens	70-75
15669327-12	2004	The high reactivity of dissolved Fe(II) on the dechlorination of CCl4 in the presence of Cu(II) under anoxic conditions may enhance our understanding of the role of Fe(II) and the long-term reactivity of the zerovalent iron system in the dechlorination processes for chlorinated organic contaminants.	Iron	219-223	C-C motif chemokine ligand 4	Homo sapiens	65-69
15465821-1	2004	Heme oxygenase-1 is an antioxidant defense enzyme that converts heme to biliverdin, iron, and carbon monoxide.	Iron	84-88	heme oxygenase 1	Homo sapiens	0-16
15566364-1	2004	Missense mutations in the ferroportin gene (SLC11A3) result in haemochromatosis type 4 [HFE4, Online Mendelian Inheritance in Man (OMIM) reference 606069] or ferroportin disease, an autosomal dominant disorder characterized by predominantly reticuloendothelial iron accumulation.	Iron	261-265	solute carrier family 40 member 1	Homo sapiens	44-51
15566364-7	2004	First, this indicates that ferroportin levels must be finely regulated in order to maintain cellular iron homeostasis, and that both copies of SLC11A3 must function efficiently to prevent iron accumulation.	Iron	188-192	solute carrier family 40 member 1	Homo sapiens	143-150
20679134-1	2010	Heme oxygenase 1 (HO-1) uses molecular oxygen and electrons from NADPH cytochrome P450 reductase to convert heme to CO, ferrous iron, and biliverdin (BV).	Iron	128-132	heme oxygenase 1	Homo sapiens	0-16
15611622-6	2004	Suppression of ROS by NF-kappaB is mediated by Ferritin heavy chain (FHC)--the primary iron-storage mechanism in cells--and possibly, by the mitochondrial enzyme Mn++ superoxide dismutase (Mn-SOD).	Iron	87-91	ferritin heavy chain 1	Homo sapiens	47-67
15611622-6	2004	Suppression of ROS by NF-kappaB is mediated by Ferritin heavy chain (FHC)--the primary iron-storage mechanism in cells--and possibly, by the mitochondrial enzyme Mn++ superoxide dismutase (Mn-SOD).	Iron	87-91	ferritin heavy chain 1	Homo sapiens	69-72
15530889-8	2004	In vitro studies suggested that severe iron restriction could lead to p53-mediated neuronal apoptosis.	Iron	39-43	transformation related protein 53, pseudogene	Mus musculus	70-73
20679134-1	2010	Heme oxygenase 1 (HO-1) uses molecular oxygen and electrons from NADPH cytochrome P450 reductase to convert heme to CO, ferrous iron, and biliverdin (BV).	Iron	128-132	heme oxygenase 1	Homo sapiens	18-22
20679134-4	2010	The goal of this study was to determine whether HO-1 activity could be monitored directly by following BV generation or iron release (using the ferrous iron chelator, ferrozine) in the absence of BVR.	Iron	120-124	heme oxygenase 1	Homo sapiens	48-52
15452775-1	2004	The mechanism for the reaction between nitric oxide (NO) and O(2) bound to the heme iron of myoglobin (Mb), including the following isomerization to nitrate, has been investigated using hybrid density functional theory (B3LYP).	Iron	84-88	myoglobin	Homo sapiens	92-101
20697906-4	2010	Hepcidin is a liver-produced hormone that regulates iron metabolism in the gut and macrophages.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
15578276-2	2004	However, Abeta is a high-affinity metalloprotein that aggregates in the presence of biometals (zinc, copper, and iron), and neocortical Abeta deposition is abolished by genetic ablation of synaptic zinc in transgenic mice.	Iron	113-117	amyloid beta (A4) precursor protein	Mus musculus	9-14
15578276-3	2004	We now present in vitro evidence that trace (<or=0.8 microM) levels of zinc, copper, and iron, present as common contaminants of laboratory buffers and culture media, are the actual initiators of the classic Abeta1-42-mediated seeding process and Abeta oligomerization.	Iron	89-93	amyloid beta (A4) precursor protein	Mus musculus	208-213
20813430-5	2010	We confirmed that APAP produces a toxic intermediate (N-acetyl-p-benzoquinone imine) upon interaction of its amide group with the heme iron of CYP1A1.	Iron	135-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	143-149
15537542-6	2004	FHC-mediated inhibition of JNK signaling depends on suppressing ROS accumulation and is achieved through iron sequestration.	Iron	105-109	ferritin heavy chain 1	Homo sapiens	0-3
20682319-9	2010	In Hfe(-/-) mice, supraphysiologic doses of exogenous BMP6 improved hepcidin deficiency, reduced serum iron, and redistributed tissue iron to appropriate storage sites.	Iron	103-107	bone morphogenetic protein 6	Mus musculus	54-58
15521925-1	2004	Transferrin receptor 2 alpha (TfR2 alpha), the major product of the TfR2 gene, is the second receptor for transferrin (Tf), which can mediate cellular iron uptake in vitro.	Iron	151-155	transferrin receptor 2	Homo sapiens	0-22
15521925-1	2004	Transferrin receptor 2 alpha (TfR2 alpha), the major product of the TfR2 gene, is the second receptor for transferrin (Tf), which can mediate cellular iron uptake in vitro.	Iron	151-155	transferrin receptor 2	Homo sapiens	30-34
15521925-1	2004	Transferrin receptor 2 alpha (TfR2 alpha), the major product of the TfR2 gene, is the second receptor for transferrin (Tf), which can mediate cellular iron uptake in vitro.	Iron	151-155	transferrin receptor 2	Homo sapiens	68-72
20682319-9	2010	In Hfe(-/-) mice, supraphysiologic doses of exogenous BMP6 improved hepcidin deficiency, reduced serum iron, and redistributed tissue iron to appropriate storage sites.	Iron	134-138	bone morphogenetic protein 6	Mus musculus	54-58
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	100-104	transferrin receptor 2	Homo sapiens	24-28
20533066-3	2010	However, a liver with acquired iron overload synthesizes an adequate amount of hepcidin.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	79-87
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	100-104	transferrin receptor 2	Homo sapiens	69-73
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	137-141	transferrin receptor 2	Homo sapiens	24-28
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	137-141	transferrin receptor 2	Homo sapiens	69-73
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	137-141	transferrin receptor 2	Homo sapiens	24-28
15521925-2	2004	Homozygous mutations of TfR2 cause haemochromatosis, suggesting that TfR2 alpha may not be a simple iron transporter, but a regulator of iron by identifying iron-Tf.	Iron	137-141	transferrin receptor 2	Homo sapiens	69-73
15521925-8	2004	Although human TfR1 and TfR2 alpha share an essential structure (RGD) for ligand-binding, they have clearly different ligand specificities, which may be related to the differences in their roles in iron metabolism.	Iron	198-202	transferrin receptor 2	Homo sapiens	24-28
15528154-7	2004	Abnormally high indices of iron status were found in subjects C282Y/H63D heterozygous for the N196K hemojuvelin mutation and the -72C &gt; T hepcidin substitution.	Iron	27-31	hemojuvelin BMP co-receptor	Homo sapiens	100-111
15528154-7	2004	Abnormally high indices of iron status were found in subjects C282Y/H63D heterozygous for the N196K hemojuvelin mutation and the -72C &gt; T hepcidin substitution.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	141-149
15528156-1	2004	Ceruloplasmin (Cp) is an abundant, copper-containing plasma protein with an important role in iron homeostasis.	Iron	94-98	ceruloplasmin	Mus musculus	0-13
20533066-4	2010	Thus, hepcidin could function as a biochemical marker for differential diagnosis of iron overload syndromes.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	6-14
20727554-5	2010	Dissolved S(-II) is able to accumulate due to limited iron availability and S(0) is largely its partial oxidation product.	Iron	54-58	transcription elongation factor A1	Homo sapiens	10-15
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	92-96	heme oxygenase 1	Homo sapiens	28-32
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	92-96	heme oxygenase 1	Homo sapiens	155-159
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	138-142	heme oxygenase 1	Homo sapiens	28-32
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	138-142	heme oxygenase 1	Homo sapiens	155-159
20628150-5	2010	Furthermore, we provide evidence that hepatocyte-derived Hif-2 is involved in the regulation of iron metabolism genes, supporting a role for HIF-2 in the coordination of EPO synthesis with iron homeostasis.	Iron	96-100	erythropoietin	Mus musculus	170-173
16265043-0	2004	Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	35-43
16265043-1	2004	The defensin-like circulatory peptide hepcidin is the iron-regulatory hormone that links innate immunity and iron metabolism.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	38-46
20702403-0	2010	Role of H-1 and H-2 subunits of soybean seed ferritin in oxidative deposition of iron in protein.	Iron	81-85	ferritin-1, chloroplastic	Glycine max	45-53
16265043-2	2004	In response to inflammatory stimuli, the liver produces hepcidin: this antimicrobial peptide then limits the iron that is vital to invading pathogens, by decreasing iron release/transfer from enterocytes and macrophages and causing secondary hypoferremia.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	56-64
16265043-2	2004	In response to inflammatory stimuli, the liver produces hepcidin: this antimicrobial peptide then limits the iron that is vital to invading pathogens, by decreasing iron release/transfer from enterocytes and macrophages and causing secondary hypoferremia.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	56-64
16265043-4	2004	When iron is scarce, the rate at which it is released into the bloodstream must be enhanced: indeed, iron starvation and hypoxia readily abrogate hepcidin expression.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	146-154
16265043-4	2004	When iron is scarce, the rate at which it is released into the bloodstream must be enhanced: indeed, iron starvation and hypoxia readily abrogate hepcidin expression.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	146-154
20702403-2	2010	Prior to this study, however, the function of the two subunits in oxidative deposition of iron in ferritin was unknown.	Iron	90-94	ferritin-1, chloroplastic	Glycine max	98-106
16265043-5	2004	Conversely, if excess iron enters the circulation, hepcidin transcription is turned on and iron release from the intestine and macrophages abrogated.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	51-59
16265043-6	2004	Circumstantial evidence indicates that the effect of circulatory iron on hepcidin requires functional HFE and hemojuvelin, two proteins of unknown function that have recently been linked to human hereditary hemochromatosis.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	73-81
20889129-3	2010	Here, we identify an essential function of the conserved cytosolic monothiol glutaredoxins Grx3 and Grx4 in intracellular iron trafficking and sensing.	Iron	122-126	glutaredoxin 3	Homo sapiens	91-95
16265043-6	2004	Circumstantial evidence indicates that the effect of circulatory iron on hepcidin requires functional HFE and hemojuvelin, two proteins of unknown function that have recently been linked to human hereditary hemochromatosis.	Iron	65-69	hemojuvelin BMP co-receptor	Homo sapiens	110-121
16265043-7	2004	In this disease it is likely that inadequate levels of circulating hepcidin lead to the uncontrolled release of iron from the intestine and macrophages, followed by tissue iron overload and organ damage.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	67-75
16265043-7	2004	In this disease it is likely that inadequate levels of circulating hepcidin lead to the uncontrolled release of iron from the intestine and macrophages, followed by tissue iron overload and organ damage.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	67-75
16265043-8	2004	Given its role as the iron-regulatory hormone, the modulation of hepcidin activity using agonists or antagonists might offer new treatment opportunities in different human iron-dependent disorders.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	65-73
20889129-3	2010	Here, we identify an essential function of the conserved cytosolic monothiol glutaredoxins Grx3 and Grx4 in intracellular iron trafficking and sensing.	Iron	122-126	glutaredoxin 3	Homo sapiens	100-104
20889129-4	2010	Depletion of Grx3/4 specifically impaired all iron-requiring reactions in the cytosol, mitochondria, and nucleus, including the synthesis of Fe/S clusters, heme, and di-iron centers.	Iron	46-50	glutaredoxin 3	Homo sapiens	13-17
15831128-5	2004	Hephaestin, a caeruloplasmin homologue, works in concert with the IREG1 transporter to permit Fe efflux from enterocytes for loading onto transferrin.	Iron	94-96	solute carrier family 40 member 1	Homo sapiens	66-71
20889129-4	2010	Depletion of Grx3/4 specifically impaired all iron-requiring reactions in the cytosol, mitochondria, and nucleus, including the synthesis of Fe/S clusters, heme, and di-iron centers.	Iron	141-143	glutaredoxin 3	Homo sapiens	13-17
15831128-9	2004	Furthermore, expression of both DMT1 and the basolateral Fe-efflux transporter IREG1 can be regulated by Cu, suggesting that the Fe-Cu relationship may be more complex than first thought.	Iron	57-59	solute carrier family 40 member 1	Homo sapiens	79-84
20889129-4	2010	Depletion of Grx3/4 specifically impaired all iron-requiring reactions in the cytosol, mitochondria, and nucleus, including the synthesis of Fe/S clusters, heme, and di-iron centers.	Iron	169-173	glutaredoxin 3	Homo sapiens	13-17
20889129-6	2010	The crucial task of Grx3/4 is mediated by a bridging, glutathione-containing Fe/S center that functions both as an iron sensor and in intracellular iron delivery.	Iron	115-119	glutaredoxin 3	Homo sapiens	20-24
20889129-6	2010	The crucial task of Grx3/4 is mediated by a bridging, glutathione-containing Fe/S center that functions both as an iron sensor and in intracellular iron delivery.	Iron	148-152	glutaredoxin 3	Homo sapiens	20-24
15280572-0	2004	Hepcidin: inflammation"s iron curtain.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
20626300-11	2010	This might indicate a resistance to the iron-decreasing action of hepcidin.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	66-74
20528904-7	2010	Hepcidin concentration in pregnant women was the lowest in those who had the lowest iron status.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
15363595-6	2004	Interestingly, the increase in AP-1 luciferase activity by iron was inhibited by the pretreatment of the cells with PD98059, a specific MEK1 inhibitor, and SB202190, a p38 kinase inhibitor.	Iron	59-63	mitogen-activated protein kinase kinase 1	Homo sapiens	136-140
20528904-9	2010	Hepcidin concentration in cord blood was associated with cord blood iron status, but not with maternal iron status.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
15345147-3	2004	In various models of oxidative tissue injuries, the induction of HO-1 confers protection on tissues from further damages by removing the prooxidant heme, or by virtue of the antioxidative, antiinflammatory, and/or antiapoptotic actions of one or more of the three products, i.e., carbon monoxide, biliverdin IXalpha, and iron by HO reaction.	Iron	321-325	heme oxygenase 1	Homo sapiens	65-69
20528904-10	2010	CONCLUSIONS: At term pregnancy, hepcidin concentrations are very low, allowing maximal availability of iron for the fetus.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	32-40
20528904-11	2010	Maternal and cord blood hepcidin levels were independently associated with either maternal or cord blood iron status.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	24-32
15172967-7	2004	Previously, we showed that iron increased human synovial cell proliferation and induced c-myc expression.	Iron	27-31	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	88-93
20796026-4	2010	An unbiased motif search of the transferrin promoter region showed that CP2 binds to the transferrin promoter, an iron-regulating protein, and regulates transferrin transcription.	Iron	114-118	ceruloplasmin	Homo sapiens	72-75
15178582-0	2004	Inhibition of iron transport across human intestinal epithelial cells by hepcidin.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	73-81
15178582-3	2004	Incubation with hepcidin significantly decreased apical iron uptake by Caco-2 cells.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	16-24
15178582-4	2004	This was accompanied by a decrease in both the protein and the mRNA expression of the iron-response element containing variant of the divalent metal transporter (DMT1[+IRE]).	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	162-166
20658468-3	2010	Hepcidin, the central regulator of iron homeostasis, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
15361505-0	2004	Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	8-16
15361505-7	2004	CONCLUSION: These results suggest that the delayed increase in iron absorption following stimulated erythropoiesis is attributable to a lag in the hepcidin response rather than crypt programming, and are consistent with a direct effect of the hepcidin pathway on mature villus enterocytes.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	147-155
15361505-7	2004	CONCLUSION: These results suggest that the delayed increase in iron absorption following stimulated erythropoiesis is attributable to a lag in the hepcidin response rather than crypt programming, and are consistent with a direct effect of the hepcidin pathway on mature villus enterocytes.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	243-251
20658468-3	2010	Hepcidin, the central regulator of iron homeostasis, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	0-8
15282205-1	2004	Mitochondrial ferritin (MtF) is structurally and functionally similar to the cytosolic ferritins, molecules designed to store and detoxify cellular iron.	Iron	148-152	ferritin mitochondrial	Homo sapiens	0-22
15282205-1	2004	Mitochondrial ferritin (MtF) is structurally and functionally similar to the cytosolic ferritins, molecules designed to store and detoxify cellular iron.	Iron	148-152	ferritin mitochondrial	Homo sapiens	24-27
20658468-3	2010	Hepcidin, the central regulator of iron homeostasis, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	0-8
15282205-2	2004	MtF expression in human and mouse is restricted to the testis and few tissues, and it is abundant in the erythroblasts of patients with sideroblastic anemia, where it is thought to protect the mitochondria from the damage caused by iron loading.	Iron	232-236	ferritin mitochondrial	Homo sapiens	0-3
15282205-4	2004	We expressed human MtF in frataxin-deficient yeast cells, a well-characterized model of mitochondrial iron overload and oxidative damage.	Iron	102-106	ferritin mitochondrial	Homo sapiens	19-22
20658468-7	2010	Hepatic expression of BMP/Smad-related genes was examined in 20 HFE-HH males with significant iron overload, and compared to seven male HFE wild-type controls using quantitative real-time reverse transcription polymerase chain reaction.	Iron	94-98	bone morphogenetic protein 1	Homo sapiens	22-25
15282205-5	2004	The human MtF precursor was efficiently imported by yeast mitochondria and processed to functional ferritin that actively sequestered iron in the organelle.	Iron	134-138	ferritin mitochondrial	Homo sapiens	10-13
15282205-6	2004	MtF expression rescued the respiratory deficiency caused by the loss of frataxin protecting the activity of iron-sulfur enzymes and enabling frataxin-deficient cells to grow on non-fermentable carbon sources.	Iron	108-112	ferritin mitochondrial	Homo sapiens	0-3
19968722-11	2010	Longitudinal studies focusing on changes in serum hepcidin levels are required to address the question whether hepcidin may contribute to iron metabolism disturbances in multi-times blood donors.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	111-119
15282205-7	2004	Furthermore, MtF expression prevented the development of mitochondrial iron overload, preserved mitochondrial DNA integrity and increased cell resistance to H2O2.	Iron	71-75	ferritin mitochondrial	Homo sapiens	13-16
15282205-8	2004	The data show that MtF can substitute for most frataxin functions in yeast, suggesting that frataxin is directly involved in mitochondrial iron-binding and detoxification.	Iron	139-143	ferritin mitochondrial	Homo sapiens	19-22
21090049-0	2010	Hepcidin: the link to understanding iron regulation.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
20517606-0	2010	Increased hepcidin production impairs iron metabolism after pancreatoduodenectomy.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	10-18
15338274-5	2004	We identified a novel D270V mutation in the SLC40A1 gene in a Black South African female with iron overload.	Iron	94-98	solute carrier family 40 member 1	Homo sapiens	44-51
15338274-7	2004	In Africans with iron overload not related to the HFE gene, the possible involvement of the SLC40A1 and CYBRD1 genes was demonstrated for the first time.	Iron	17-21	solute carrier family 40 member 1	Homo sapiens	92-99
20517606-11	2010	Because hepcidin is known to divert iron to storage-type ferritin rather than to erythropoiesis, iron administration intended for erythropoiesis during this period may be ineffective.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	8-16
20732302-8	2010	Loss of HO-1 activity may result in increased oxidative neurotoxicity, anemia, growth retardation and iron deposition.	Iron	102-106	heme oxygenase 1	Homo sapiens	8-12
15763974-5	2004	For these reasons, it has been proposed that hepcidin is a primary factor in the pathogenesis of the anaemia of chronic disease (ACD), a cytokine-mediated anaemia commonly encountered in clinical practice and characterized by hypoferraemia with adequate reticuloendothelial iron stores.	Iron	274-278	hepcidin antimicrobial peptide	Homo sapiens	45-53
15763974-8	2004	Hepcidin appears to be a major factor in the systemic iron abnormalities seen in ACD; whether it contributes to the other aspects of the pathogenesis of the syndrome requires further investigation.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
20823165-6	2010	Iron accumulation was observed in myc-hFTH cells and tumors by Prussian blue staining and iron binding assays.	Iron	0-4	ferritin heavy chain 1	Homo sapiens	38-42
15456844-4	2004	Iron depletion induces DNA double-strand breaks in treated cells, and activates a DNA damage response that results in focal phosphorylation of histone H2AX, focal accumulation of replication protein A (RPA) and ATR (ATM and Rad3-related kinase), and activation of CHK1 kinase.	Iron	0-4	ATM serine/threonine kinase	Homo sapiens	216-219
15327944-6	2004	We have shown that the expression levels of aco-1 and ftn-1 genes are both regulated by iron treatment but in opposite ways.	Iron	88-92	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	44-49
20823165-6	2010	Iron accumulation was observed in myc-hFTH cells and tumors by Prussian blue staining and iron binding assays.	Iron	90-94	ferritin heavy chain 1	Homo sapiens	38-42
15327944-6	2004	We have shown that the expression levels of aco-1 and ftn-1 genes are both regulated by iron treatment but in opposite ways.	Iron	88-92	Ferritin	Caenorhabditis elegans	54-59
15327944-7	2004	Interestingly, mutant animals lacking ACO-1 and FTN-1 show significantly reduced life-span upon iron stress, while N2 and ftn-2 animals show no difference.	Iron	96-100	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	38-43
20687613-1	2010	Tryptophan hydroxylase (TrpH) uses a non-heme mononuclear iron center to catalyze the tetrahydropterin-dependent hydroxylation of tryptophan to 5-hydroxytryptophan.	Iron	58-62	tryptophan hydroxylase 1	Homo sapiens	0-22
15327944-7	2004	Interestingly, mutant animals lacking ACO-1 and FTN-1 show significantly reduced life-span upon iron stress, while N2 and ftn-2 animals show no difference.	Iron	96-100	Ferritin	Caenorhabditis elegans	48-53
15327944-8	2004	Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans.	Iron	76-80	Ferritin	Caenorhabditis elegans	25-30
15327944-8	2004	Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans.	Iron	76-80	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	35-40
15327944-8	2004	Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans.	Iron	103-107	Ferritin	Caenorhabditis elegans	25-30
15327944-8	2004	Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans.	Iron	103-107	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	35-40
15327944-8	2004	Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans.	Iron	103-107	Ferritin	Caenorhabditis elegans	25-30
15327944-8	2004	Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans.	Iron	103-107	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	35-40
20687613-1	2010	Tryptophan hydroxylase (TrpH) uses a non-heme mononuclear iron center to catalyze the tetrahydropterin-dependent hydroxylation of tryptophan to 5-hydroxytryptophan.	Iron	58-62	tryptophan hydroxylase 1	Homo sapiens	24-28
20043217-4	2010	We observed that endocytosis of transferrin, which is involved in the delivery of iron to the cell, was increased after stress induced by heat shock or after incubation with inhibitors of Hsp90 function.	Iron	82-86	heat shock protein 90 alpha family class A member 1	Homo sapiens	188-193
20724518-4	2010	The ability to measure hepcidin in biologic fluids has stimulated interest in the potential applicability of this measurement as a more informative marker of iron status than the traditional iron indices such as serum ferritin and transferrin saturation.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	23-31
20924211-2	2010	Prohepcidin is an easily measurable precursor of hepcidin, which is a key regulator of iron homeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	3-11
23956658-5	2010	UPC2 plays roles in ergosterol biosynthesis, which is also affected by the availability of iron in Saccharomyces cerevisiae and Candida albicans.	Iron	91-95	Upc2p	Saccharomyces cerevisiae S288C	0-4
21152835-2	2010	Information on the metabolism of hepcidin and its possible significance as a biochemical parameter in iron deficiency anemia is reported in this review, which was based on a survey of the databases PubMed and LILACS for articles published between 2006 and 2010 on hepcidin as a biomarker for the regulation of iron metabolism.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	33-41
21152835-7	2010	Hepcidin binds to ferroportin, regulating iron release into plasma.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
21152835-8	2010	When hepcidin concentrations are low, ferroportin molecules are displayed on the plasma membrane and release iron.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	5-13
21152835-9	2010	When hepcidin levels increase, hepcidin binds to ferroportin molecules inducing their internalization and degradation, and iron release is decreased progressively.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	5-13
20832528-1	2010	BACKGROUND: Heme oxygenase-1 (HO-1) is the enzyme that catabolizes heme into carbon monoxide, biliverdin, and free iron.	Iron	115-119	heme oxygenase 1	Homo sapiens	12-28
20832528-1	2010	BACKGROUND: Heme oxygenase-1 (HO-1) is the enzyme that catabolizes heme into carbon monoxide, biliverdin, and free iron.	Iron	115-119	heme oxygenase 1	Homo sapiens	30-34
21161013-10	2010	Hepcidin has been shown to be regulated by iron, inflammation, oxidative stress, hypoxia, alcohol, hepatitis C and obesity.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
20679243-2	2010	JMJD6 binds alpha-ketoglutarate and iron and has been characterized as either a histone arginine demethylase or U2AF65 lysyl hydroxylase.	Iron	36-40	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
20684070-3	2010	JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues in arginine-serine-rich domains of RNA splicing-related proteins.	Iron	20-24	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
20684597-1	2010	As recently discovered, matriptase-2, a type II transmembrane serine protease, plays a crucial role in body iron homeostasis by down-regulating hepcidin expression, which results in increased iron levels.	Iron	192-196	hepcidin antimicrobial peptide	Homo sapiens	144-152
20686179-1	2010	Ferroportin and hepcidin are critical proteins for the regulation of systemic iron homeostasis.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	16-24
20686179-2	2010	Ferroportin is the only known mechanism for export of intracellular non-heme-associated iron; its stability is regulated by the hormone hepcidin.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	136-144
21113495-3	2010	Intraperitoneal injections of lactoferrin (10 mg/day) for 4 days starting from day 7 led to an increase in hemoglobin level to 109% and of serum iron to 125% on day 14.	Iron	145-149	lactotransferrin	Rattus norvegicus	30-41
21113495-6	2010	The results indicate that lactoferrin modified ceruloplasmin activity in vivo, promoting normalization of iron metabolism.	Iron	106-110	lactotransferrin	Rattus norvegicus	26-37
20542038-9	2010	The role of hepcidin in the pathogenesis of hemochromatosis reveals its similarities to endocrine diseases such as diabetes and indicates new approaches to diagnosis and management of this common disorder in iron metabolism.	Iron	208-212	hepcidin antimicrobial peptide	Homo sapiens	12-20
20220061-13	2010	These observations reveal the existence of a new cellular pathway in hepcidin mediated degradation of ferroportin and open a new area of investigation in mammalian iron homeostasis.	Iron	164-168	hepcidin antimicrobial peptide	Homo sapiens	69-77
20410187-1	2010	BACKGROUND: Divalent metal transporter 1 (DMT1) is a widely expressed metal-iron transporter gene encoding four variant mRNA transcripts, differing for alternative promoter at 5" (DMT1 1A and 1B) and alternative splicing at 3" UTR, differing by a specific sequence either containing or lacking an iron regulatory element (+IRE and -IRE, respectively).	Iron	76-80	solute carrier family 11 member 2	Homo sapiens	12-40
20410187-1	2010	BACKGROUND: Divalent metal transporter 1 (DMT1) is a widely expressed metal-iron transporter gene encoding four variant mRNA transcripts, differing for alternative promoter at 5" (DMT1 1A and 1B) and alternative splicing at 3" UTR, differing by a specific sequence either containing or lacking an iron regulatory element (+IRE and -IRE, respectively).	Iron	76-80	solute carrier family 11 member 2	Homo sapiens	42-46
20410187-1	2010	BACKGROUND: Divalent metal transporter 1 (DMT1) is a widely expressed metal-iron transporter gene encoding four variant mRNA transcripts, differing for alternative promoter at 5" (DMT1 1A and 1B) and alternative splicing at 3" UTR, differing by a specific sequence either containing or lacking an iron regulatory element (+IRE and -IRE, respectively).	Iron	76-80	solute carrier family 11 member 2	Homo sapiens	180-184
20410187-9	2010	MiR-Let-7d impairs erythroid differentiation of K562 cells by accumulation of iron in the endosomes.	Iron	78-82	myosin regulatory light chain interacting protein	Homo sapiens	0-3
20410187-10	2010	CONCLUSIONS: Overall, these data suggest that miR-Let-7d participates in the finely tuned regulation of iron metabolism by targeting DMT1-IRE isoform in erythroid cells.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	133-137
20444958-0	2010	Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	167-175
20444958-2	2010	Inflammation-mediated up-regulation of hepcidin, a key mediator of iron homeostasis, may be a contributing factor.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	39-47
20482310-1	2010	Xeroderma pigmentosum complementation group D protein (XPD) is an iron-sulfur cluster containing 5"-3" helicase and, in humans, part of the transcription factor TFIIH.	Iron	66-70	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	55-58
19809335-11	2010	The polymorphism does not correlate with iron overload suggesting that TLR4 plays a role in an inflammatory process arising from toxic effects of iron accumulation.	Iron	146-150	toll like receptor 4	Homo sapiens	71-75
18775584-3	2010	In contrast, MTF-1 overexpression results in resistant flies with prolonged longevity on iron or cadmium-supplemented media but shortened life-span on zinc-supplemented medium.	Iron	89-93	Metal response element-binding Transcription Factor-1	Drosophila melanogaster	13-18
15166119-1	2004	Lactoferrin is an iron-binding glycoprotein present in epithelial secretions, such as milk, and in the secondary granules of neutrophils.	Iron	18-22	lactotransferrin	Mus musculus	0-11
20694291-0	2010	[Pro-hepcidin, its relation with indicators of iron metabolism and of inflammation in patients hemodialyzed treated or not with recombinant erythropoietin].	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	5-13
15339940-1	2004	Myoglobin is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin ring:iron ion complex.	Iron	178-182	myoglobin	Homo sapiens	0-9
20694291-1	2010	UNLABELLED: Hepcidin, an antimicrobial peptide which synthesis is regulated by iron status and inflammation, plays an important role in iron homeostasis in hemodialysed (HD) patients.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	12-20
15271520-1	2004	Lactoferrin (Lf) is a mammalian iron binding protein present in external secretions and in polymorphonuclear leukocytes.	Iron	32-36	lactotransferrin	Bos taurus	0-11
20694291-1	2010	UNLABELLED: Hepcidin, an antimicrobial peptide which synthesis is regulated by iron status and inflammation, plays an important role in iron homeostasis in hemodialysed (HD) patients.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	12-20
20210929-1	2010	BACKGROUND: Low serum hepcidin levels provide a physiologic response to iron demand in patients with iron deficiency (ID).	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	22-30
15255869-1	2004	The Yellow Stripe-Like (YSL) family of proteins has been identified based on sequence similarity to maize Yellow Stripe1 (YS1), the transporter responsible for the primary uptake of iron from the soil.	Iron	182-186	iron-phytosiderophore transporter yellow stripe 1	Zea mays	122-125
15255869-2	2004	YS1 transports iron that is complexed by specific plant-derived Fe(III) chelators called phytosiderophores (PS).	Iron	15-19	iron-phytosiderophore transporter yellow stripe 1	Zea mays	0-3
15255869-5	2004	Here we show that Arabidopsis YSL2 (At5g24380) transports iron and copper when these metals are chelated by NA.	Iron	58-62	YELLOW STRIPE like 2	Arabidopsis thaliana	30-34
15255869-7	2004	YSL2 transcription is regulated by the levels of iron and copper in the growth medium.	Iron	49-53	YELLOW STRIPE like 2	Arabidopsis thaliana	0-4
20210929-4	2010	RESULTS: Iron variables and hepcidin levels were significantly suppressed in iron-deficient blood donors compared to healthy volunteers.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	28-36
15255870-1	2004	We identified 18 putative yellow stripe 1 (YS1)-like genes (OsYSLs) in the rice genome that exhibited 36-76% sequence similarity to maize iron(III)-phytosiderophore transporter YS1.	Iron	138-142	iron-phytosiderophore transporter yellow stripe 1	Zea mays	43-46
15255870-1	2004	We identified 18 putative yellow stripe 1 (YS1)-like genes (OsYSLs) in the rice genome that exhibited 36-76% sequence similarity to maize iron(III)-phytosiderophore transporter YS1.	Iron	138-142	iron-phytosiderophore transporter yellow stripe 1	Zea mays	177-180
20547883-3	2010	The high protein sequence similarity between Fdx1 and its yeast adrenodoxin homologue (Yah1) suggested that Fdx1, like Yah1, may be involved in the biosynthesis of heme A and Fe/S clusters, two versatile and essential protein cofactors.	Iron	175-178	adrenodoxin	Saccharomyces cerevisiae S288C	87-91
15251429-0	2004	Miraculous catch of iron-sulfur protein sequences in the Sargasso Sea.	Iron	20-24	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
15251429-2	2004	Iron-sulfur proteins, which are ancient, diverse and ubiquitous, have been implemented here to further probe the sequence diversity of the Sargasso Sea database (SSDB).	Iron	0-4	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	148-151
20547883-3	2010	The high protein sequence similarity between Fdx1 and its yeast adrenodoxin homologue (Yah1) suggested that Fdx1, like Yah1, may be involved in the biosynthesis of heme A and Fe/S clusters, two versatile and essential protein cofactors.	Iron	175-178	adrenodoxin	Saccharomyces cerevisiae S288C	119-123
15237985-3	2004	Upon half-reaction of the oxidized enzyme with CoM-SH in the absence of CoB-SH, an iron-based paramagnetic intermediate is formed, designated CoM-Hdr.	Iron	83-87	metabolism of cobalamin associated B	Homo sapiens	72-75
20518085-1	2010	Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron.	Iron	116-120	heme oxygenase 1	Homo sapiens	0-16
20518085-1	2010	Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron.	Iron	116-120	heme oxygenase 1	Homo sapiens	18-22
20117074-1	2010	Iron-sulfur cluster N2 of complex I (proton pumping NADH:quinone oxidoreductase) is the immediate electron donor to ubiquinone.	Iron	0-4	crystallin zeta	Homo sapiens	57-79
15100228-1	2004	HscA, a specialized bacterial hsp70-class chaperone, interacts with the iron-sulfur cluster assembly protein IscU by recognizing a conserved LPPVK sequence motif at positions 99-103.	Iron	72-76	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	30-35
20145976-0	2010	Contribution of bovine lactoferrin inter-lobe region to iron binding stability and antimicrobial activity against Staphylococcus aureus.	Iron	56-60	lactotransferrin	Bos taurus	23-34
15231240-5	2004	Iron has also been recently been implicated in promotion of alpha-synuclein aggregation either directly or via increasing levels of oxidative stress suggesting an important role for it in Lewy body formation, another important hallmark of the disease.	Iron	0-4	synuclein alpha	Homo sapiens	60-75
20145976-1	2010	The investigation of the recombinant bovine lactoferrin-derived antimicrobial protein (rBLfA) demonstrates that the inter-lobe region of bovine lactoferrin contributes to iron binding stability and antimicrobial activity against Staphylococcus aureus.	Iron	171-175	lactotransferrin	Bos taurus	44-55
15272854-5	2004	One especially promising NMR approach involves the use of paramagnetic induced relaxation effects to measure distances of ligand atoms from the heme iron in CYP enzymes.	Iron	149-153	peptidylprolyl isomerase G	Homo sapiens	157-160
20145976-1	2010	The investigation of the recombinant bovine lactoferrin-derived antimicrobial protein (rBLfA) demonstrates that the inter-lobe region of bovine lactoferrin contributes to iron binding stability and antimicrobial activity against Staphylococcus aureus.	Iron	171-175	lactotransferrin	Bos taurus	144-155
20157763-1	2010	Lactoferrin is an iron-binding glycoprotein that exhibits a range of health benefits including immune regulation and disease prevention derived from its structural properties.	Iron	18-22	lactotransferrin	Bos taurus	0-11
20299375-1	2010	BACKGROUND AND OBJECTIVES: Hepcidin, the principal regulator of iron homeostasis, may play a critical role in the response of patients with anemia to iron and erythropoiesis-stimulating agent therapy; however, the contribution of hepcidin to iron maldistribution and anemia in hemodialysis (HD) patients and the ability of HD to lower serum hepcidin levels have not been fully characterized.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	27-35
15192265-1	2004	BACKGROUND: Lactoferrin, LF, a multifunctional iron- and heparin-binding protein, present in exocrine body secretions and leukocytes, is remarkably resistant to proteolysis.	Iron	47-51	HLF transcription factor, PAR bZIP family member	Homo sapiens	25-27
15192265-2	2004	Ingested bovine iron-unsaturated LF, apo-bLF, suppresses VEGF-A-mediated angiogenesis in a previously described rat mesentery angiogenesis assay, possibly explaining, at least in part, its established anticancer effect in rats and mice.	Iron	16-20	HLF transcription factor, PAR bZIP family member	Homo sapiens	33-35
15170358-10	2004	Shift of the 4" proton of flurbiprofen closer to the heme iron of CYP2C9 in the presence of dapsone may play a role in activation.	Iron	58-62	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	66-72
20299375-1	2010	BACKGROUND AND OBJECTIVES: Hepcidin, the principal regulator of iron homeostasis, may play a critical role in the response of patients with anemia to iron and erythropoiesis-stimulating agent therapy; however, the contribution of hepcidin to iron maldistribution and anemia in hemodialysis (HD) patients and the ability of HD to lower serum hepcidin levels have not been fully characterized.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	27-35
20299375-1	2010	BACKGROUND AND OBJECTIVES: Hepcidin, the principal regulator of iron homeostasis, may play a critical role in the response of patients with anemia to iron and erythropoiesis-stimulating agent therapy; however, the contribution of hepcidin to iron maldistribution and anemia in hemodialysis (HD) patients and the ability of HD to lower serum hepcidin levels have not been fully characterized.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	27-35
20299375-5	2010	Multivariate regression analysis showed that serum hepcidin was independently predicted by ferritin and high-sensitivity C-reactive protein in the pediatric group and ferritin, percentage of iron saturation, and high-sensitivity C-reactive protein in the adult group.	Iron	191-195	hepcidin antimicrobial peptide	Homo sapiens	51-59
15168383-13	2004	CONCLUSION: We show for the first time that increased iron levels in PMNLs of HD patients were associated with downregulation of ferroportin 1 and upregulation of TfR, which might be linked to hypercytokinemia.	Iron	54-58	solute carrier family 40 member 1	Homo sapiens	129-142
20593054-3	2010	We report a 26-year old woman with a severe iron overload, affected by hypogonadotropic hypogonadism and moderate dilative cardiomyopathy, in whom the molecular analysis revealed a homozygous genotype for G320V mutation in the HJV gene.	Iron	44-48	hemojuvelin BMP co-receptor	Homo sapiens	227-230
15149817-3	2004	Folding of cyt c leads to a state having the heme iron coordinated to a histidine (His18) and a methionine (Met80) as axial ligands.	Iron	50-54	cytochrome c, somatic	Equus caballus	11-16
20527030-8	2010	H(2)O binding to metmyoglobin (17,585 Da), where the heme iron is in the ferric oxidation state, is observed in ESI-MS. CO binding to Mb (17,595 Da), on the other hand, can be only observed after the heme iron is reduced to the ferrous form.	Iron	58-62	myoglobin	Homo sapiens	134-136
15158327-7	2004	Both hepatic HAMP and HAMP2 mRNA levels were elevated by iron overload, but treatment with lipopolysaccharide increased only HAMP mRNA.	Iron	57-61	hepcidin antimicrobial peptide 2	Mus musculus	22-27
19890342-1	2010	OBJECTIVE: Prohepcidin (Pro-Hep), synthesized in the liver, is the prohormone of hepcidin (Hep), which reduces iron absorption in the gut; its synthesis is enhanced by inflammation and is reduced during hypoxia.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	14-22
15214510-6	2004	Protein 3 (identified as transferrin by nephelometry) contained the most iron while Protein 1 (called "toxiferrin") contained significantly less iron (p &lt; 0.00001).	Iron	73-77	heat shock protein family B (small) member 3	Homo sapiens	0-9
19890342-1	2010	OBJECTIVE: Prohepcidin (Pro-Hep), synthesized in the liver, is the prohormone of hepcidin (Hep), which reduces iron absorption in the gut; its synthesis is enhanced by inflammation and is reduced during hypoxia.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	91-94
20502498-2	2010	The main component of LB is aggregated alpha-synuclein, present in the substantia nigra where iron accumulation also occurs.	Iron	94-98	synuclein alpha	Homo sapiens	39-54
15205095-2	2004	The authors therefore studied the iron load in RHD by measuring cord blood ferritin levels in babies affected with RHD and gestational age- and weight-matched controls.	Iron	34-38	Rh blood group D antigen	Homo sapiens	47-50
15205095-5	2004	The results indicate that there is an increased intrauterine iron load in babies with RHD, independent from intrauterine transfusions and rate of hemolysis.	Iron	61-65	Rh blood group D antigen	Homo sapiens	86-89
15103330-5	2004	Assembly of its Fe/S clusters crucially depends on components of the mitochondrial Fe/S cluster biosynthesis apparatus such as the cysteine desulphurase Nfs1p, the ferredoxin Yah1p and the ABC transporter Atm1p.	Iron	16-18	adrenodoxin	Saccharomyces cerevisiae S288C	175-180
15103330-5	2004	Assembly of its Fe/S clusters crucially depends on components of the mitochondrial Fe/S cluster biosynthesis apparatus such as the cysteine desulphurase Nfs1p, the ferredoxin Yah1p and the ABC transporter Atm1p.	Iron	83-85	adrenodoxin	Saccharomyces cerevisiae S288C	175-180
15054143-8	2004	FP1 expression was localized on the basolateral membrane of enterocytes and increased with low iron stores.	Iron	95-99	solute carrier family 40 member 1	Homo sapiens	0-3
20502498-3	2010	The present study aimed to study the relationship between iron and alpha-synuclein aggregation.	Iron	58-62	synuclein alpha	Homo sapiens	67-82
20502498-7	2010	At the concentrations of 5 mmol/L and 10 mmol/L, iron induced alpha-synuclein aggregation more severely than at the concentration of 1 mmol/L.	Iron	49-53	synuclein alpha	Homo sapiens	62-77
20406921-6	2010	Analyzing parameters of iron metabolism, hepcidin levels showed a positive correlation with ferritin (P &lt; .001) and an inverse correlation to iron and iron-binding capacity.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	41-49
15703643-7	2004	A mutation in ferroportin 1 produced a form of hemochromatosis with excessive iron in hepatocytes and also in Kupffer cells and macrophages.	Iron	78-82	solute carrier family 40 member 1	Homo sapiens	14-27
15703644-6	2004	Other data suggests that the altered regulation of the peptide hepcidin may play a pivotal role in the development of the iron overload phenotype in patients with hemochromatosis.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	63-71
20406921-6	2010	Analyzing parameters of iron metabolism, hepcidin levels showed a positive correlation with ferritin (P &lt; .001) and an inverse correlation to iron and iron-binding capacity.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	41-49
20406921-6	2010	Analyzing parameters of iron metabolism, hepcidin levels showed a positive correlation with ferritin (P &lt; .001) and an inverse correlation to iron and iron-binding capacity.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	41-49
15128303-1	2004	The divalent metal transporter (DMT1) is a 12-transmembrane domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	99-103	solute carrier family 11 member 2	Homo sapiens	32-36
20406921-11	2010	Elevated hepcidin levels result in iron restriction and signs of anemia of chronic inflammation, although hepcidin-independent mechanisms contribute to development of anemia in HL.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	9-17
15128303-1	2004	The divalent metal transporter (DMT1) is a 12-transmembrane domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	131-135	solute carrier family 11 member 2	Homo sapiens	32-36
20081092-1	2010	In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	59-67
15082573-0	2004	Hepcidin and its role in iron absorption.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
15082573-4	2004	Over the past 10 years, major advances have been made in understanding the genetics of iron metabolism and this has led to identification of a number of new proteins, including hepcidin, involved in iron homeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	177-185
20392104-1	2010	Functional regulation of myoglobin (Mb) is thought to be achieved through the heme environment furnished by nearby amino acid residues, and subtle tuning of the intrinsic heme Fe reactivity.	Iron	176-178	myoglobin	Homo sapiens	25-34
15082573-4	2004	Over the past 10 years, major advances have been made in understanding the genetics of iron metabolism and this has led to identification of a number of new proteins, including hepcidin, involved in iron homeostasis.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	177-185
20232450-1	2010	Mutations leading to abrogation of matriptase-2 proteolytic activity in humans are associated with an iron-refractory iron deficiency anemia (IRIDA) due to elevated hepcidin levels.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	165-173
15107503-7	2004	YS1 is able to translocate iron that is bound either by PS or by the related compound, nicotianamine; thus, the role of YS1 may be to transport either of these complexes.	Iron	27-31	iron-phytosiderophore transporter yellow stripe 1	Zea mays	0-3
15107503-7	2004	YS1 is able to translocate iron that is bound either by PS or by the related compound, nicotianamine; thus, the role of YS1 may be to transport either of these complexes.	Iron	27-31	iron-phytosiderophore transporter yellow stripe 1	Zea mays	120-123
15107503-8	2004	Ys1 expression at both the mRNA and protein levels responds rapidly to changes in iron availability but is not strongly affected by limitation of copper or zinc.	Iron	82-86	iron-phytosiderophore transporter yellow stripe 1	Zea mays	0-3
20378668-7	2010	The transcriptional up-regulation of HO1 in plants responds to many agents, such as light, UV, iron deprivation, reactive oxygen species (ROS), abscisic acid (ABA), and haematin.	Iron	95-99	heme oxygenase 1	Homo sapiens	37-40
15051895-2	2004	However, Fe-mediated regulation of ceruloplasmin has never been investigated in humans.	Iron	9-11	ceruloplasmin	Homo sapiens	35-48
20162334-3	2010	Whole genome gene profiling using DNA chip technology revealed that genes involved in cholesterol and fatty acid metabolism (low-density lipoprotein receptor, LDL-R; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (HMGCS1) and fatty acid desaturase 1 (FADS1) are up-regulated after exposure of vascular smooth muscle cells with soluble ferrous iron.	Iron	345-349	low density lipoprotein receptor	Homo sapiens	125-157
14604961-4	2004	This striking observation led us to ask whether hepc1 and hepc2 performed the same biologic activity with regard to iron metabolism in the mouse.	Iron	116-120	hepcidin antimicrobial peptide 2	Mus musculus	58-63
14604961-9	2004	These data provide evidence that hepc2 does not act on iron metabolism like hepc1 and give clues for the identification of amino acids important for the iron-regulatory action of the mature 25-amino acid peptide.	Iron	153-157	hepcidin antimicrobial peptide 2	Mus musculus	33-38
20162334-9	2010	We postulate that both, bi- and trivalent forms of iron induce the expression of LDL-R, HMGCS1 and FADS1 by generation of highly reactive oxygen species.	Iron	51-55	low density lipoprotein receptor	Homo sapiens	81-86
20162334-9	2010	We postulate that both, bi- and trivalent forms of iron induce the expression of LDL-R, HMGCS1 and FADS1 by generation of highly reactive oxygen species.	Iron	51-55	3-hydroxy-3-methylglutaryl-CoA synthase 1	Homo sapiens	88-94
15147148-3	2004	Hepcidin, a small hepatic peptide has recently been proposed as a central mediator of dietary iron absorption.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	0-8
15112807-2	2004	Under anoxic conditions, reactions with ferrous iron sorbed at iron(hyro)xides may dominate the overall transformation of carbon tetrachloride (CCl4) and other chlorinated aliphatic hydrocarbons.	Iron	40-52	C-C motif chemokine ligand 4	Homo sapiens	144-148
20162334-9	2010	We postulate that both, bi- and trivalent forms of iron induce the expression of LDL-R, HMGCS1 and FADS1 by generation of highly reactive oxygen species.	Iron	51-55	fatty acid desaturase 1	Homo sapiens	99-104
20141569-3	2010	Alpha-synuclein has also been shown to bind metals including copper and iron.	Iron	72-76	synuclein alpha	Homo sapiens	0-15
14977880-1	2004	Heme oxygenase-1 (HO-1) degrades heme into iron, biliverdin, and carbon monoxide (CO).	Iron	43-47	heme oxygenase 1	Homo sapiens	0-16
14977880-1	2004	Heme oxygenase-1 (HO-1) degrades heme into iron, biliverdin, and carbon monoxide (CO).	Iron	43-47	heme oxygenase 1	Homo sapiens	18-22
20509117-6	2010	Transport of non-haem iron from the proximal intestinal lumen into the enterocytes is mediated by the divalent metal transporter 1 (DMT1).	Iron	22-26	solute carrier family 11 member 2	Homo sapiens	102-130
20509117-6	2010	Transport of non-haem iron from the proximal intestinal lumen into the enterocytes is mediated by the divalent metal transporter 1 (DMT1).	Iron	22-26	solute carrier family 11 member 2	Homo sapiens	132-136
15019971-0	2004	Overexpression of heme oxygenase (HO)-1 renders Jurkat T cells resistant to fas-mediated apoptosis: involvement of iron released by HO-1.	Iron	115-119	heme oxygenase 1	Homo sapiens	18-39
15019971-0	2004	Overexpression of heme oxygenase (HO)-1 renders Jurkat T cells resistant to fas-mediated apoptosis: involvement of iron released by HO-1.	Iron	115-119	heme oxygenase 1	Homo sapiens	132-136
20509118-3	2010	Pathogenetically it is induced by the upregulation of hepcidin, a recently detected acute phase protein with most important regulatory function in the iron-household.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	54-62
20509118-4	2010	As a consequence of elevated hepcidin at the same time iron absorption in the bowel as well as iron release from macrophages are reduced, resulting in sequestration of iron in the RES and therefore functional iron deficiency.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	29-37
20219396-8	2010	Pretreatment of C57BL/6 mice with iron (5mg/mouse) almost completely inhibited the EPO-induced decrease of Hamp mRNA.	Iron	34-38	erythropoietin	Mus musculus	83-86
15030991-0	2004	Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis.	Iron	19-23	solute carrier family 40 member 1	Homo sapiens	60-72
15030991-0	2004	Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	60-72
19838709-0	2010	Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients.	Iron	61-65	glutathione S-transferase kappa 1	Homo sapiens	0-25
15030991-1	2004	We report the identification of a novel mutation in ferroportin1 in an Australian family with autosomal dominant iron overload.	Iron	113-117	solute carrier family 40 member 1	Homo sapiens	52-64
20040761-5	2010	SMAD7 is an inhibitory SMAD protein that mediates a negative feedback loop to both transforming growth factor-beta and BMP signaling and that recently was shown to be coregulated with hepcidin via SMAD4 in response to altered iron availability in vivo.	Iron	226-230	SMAD family member 4	Mus musculus	197-202
15069380-0	2004	[Regulation of body iron homeostasis by hepcidin].	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	40-48
15069380-1	2004	Hepcidin is a circulating antimicrobial peptide mainly synthesized in the liver, which has been recently proposed as a factor regulating the uptake of dietary iron and its release by reticuloendothelial macrophages.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	0-8
15069380-4	2004	Discovery of the critical role of hepcidin in iron homeostasis could help in the design of new therapies for some iron metabolism disorders in humans.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	34-42
15069380-5	2004	The aim of this review is to summarize current knowledge about the function and regulation of hepcidin in iron metabolism.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	94-102
20346225-4	2010	In tumor cells, iron metabolism changes by several mechanisms, such as regulating the growth of tumor cells by transferrin, accelerating the uptake of iron by the overexpressions of transferrin receptors 1 and 2 (TfR1 and TfR2), synthesizing or secreting ferritin by some malignant tumor cells, and upregulating the level of hepcidin in patients with cancer.	Iron	16-20	transferrin receptor 2	Homo sapiens	182-211
15105252-2	2004	The concurrent expression of the ferrous iron transporter, divalent metal transporter I (DMT1), in neurons suggests that the internalization of transferrin is followed by detachment of iron within recycling endosomes and transport into the cytosol via DMT1.	Iron	41-45	solute carrier family 11 member 2	Homo sapiens	89-93
15105252-2	2004	The concurrent expression of the ferrous iron transporter, divalent metal transporter I (DMT1), in neurons suggests that the internalization of transferrin is followed by detachment of iron within recycling endosomes and transport into the cytosol via DMT1.	Iron	41-45	solute carrier family 11 member 2	Homo sapiens	252-256
15105252-3	2004	To enable DMT1-mediated export of iron from the endosome to the cytosol, ferric iron must be reduced to its ferrous form, which could be mediated by a ferric reductase.	Iron	34-38	solute carrier family 11 member 2	Homo sapiens	10-14
15105252-10	2004	Pharmacological blockage of the transferrin receptor/DMT1-mediated uptake could be a target to prevent further iron uptake.	Iron	111-115	solute carrier family 11 member 2	Homo sapiens	53-57
20346225-4	2010	In tumor cells, iron metabolism changes by several mechanisms, such as regulating the growth of tumor cells by transferrin, accelerating the uptake of iron by the overexpressions of transferrin receptors 1 and 2 (TfR1 and TfR2), synthesizing or secreting ferritin by some malignant tumor cells, and upregulating the level of hepcidin in patients with cancer.	Iron	16-20	transferrin receptor 2	Homo sapiens	222-226
15105257-0	2004	Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress.	Iron	51-55	heme oxygenase 1	Homo sapiens	0-16
20346225-4	2010	In tumor cells, iron metabolism changes by several mechanisms, such as regulating the growth of tumor cells by transferrin, accelerating the uptake of iron by the overexpressions of transferrin receptors 1 and 2 (TfR1 and TfR2), synthesizing or secreting ferritin by some malignant tumor cells, and upregulating the level of hepcidin in patients with cancer.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	325-333
15105257-2	2004	Heme oxygenase-1 (HO-1) is a 32-kDa stress protein that degrades heme to biliverdin, free iron, and carbon monoxide.	Iron	90-94	heme oxygenase 1	Homo sapiens	0-16
20346225-4	2010	In tumor cells, iron metabolism changes by several mechanisms, such as regulating the growth of tumor cells by transferrin, accelerating the uptake of iron by the overexpressions of transferrin receptors 1 and 2 (TfR1 and TfR2), synthesizing or secreting ferritin by some malignant tumor cells, and upregulating the level of hepcidin in patients with cancer.	Iron	151-155	transferrin receptor 2	Homo sapiens	182-211
15105257-2	2004	Heme oxygenase-1 (HO-1) is a 32-kDa stress protein that degrades heme to biliverdin, free iron, and carbon monoxide.	Iron	90-94	heme oxygenase 1	Homo sapiens	18-22
15105257-4	2004	A model is presented implicating glial HO-1 induction as a "final common pathway" leading to pathological iron sequestration and mitochondrial insufficiency in a host of human CNS disorders.	Iron	106-110	heme oxygenase 1	Homo sapiens	39-43
19624802-13	2010	Iron supplements given to the patients with low TSAT or ferritin, RET-He responded within 2 weeks, and this seemed to be a potential advantage of using RET-He in the estimation of iron status.	Iron	180-184	ret proto-oncogene	Homo sapiens	152-155
15248564-1	2004	In this study we investigated iron deposition in the hippocampus CA1 area and the corpus striatum pars dorsolateralis in a rat model of cerebral ischemia and ischemic tolerance.	Iron	30-34	carbonic anhydrase 1	Rattus norvegicus	65-68
15248564-5	2004	Perl"s reaction with DAB intensification demonstrated iron deposits in the CA1 area and in the corpus striatum pars dorsolateralis after 2 weeks of recirculation.	Iron	54-58	carbonic anhydrase 1	Rattus norvegicus	75-78
19624802-14	2010	RET-He is a new parameter, equivalent value to CHr, and is easily measurable on the widely spread and popular blood cell counter and is a sensitive and specific marker of iron status in dialysis patients.	Iron	171-175	ret proto-oncogene	Homo sapiens	0-3
15248564-7	2004	When the rats were exposed to 5-min ischemia 2 days before lethal 20-min ischemia, the deposition of iron in the CA1 region of the hippocampus and also in the corpus striatum pars dorsolateralis was decreased and produced a minimal number of iron-containing cells between the second and the 8th week of recirculation.	Iron	101-105	carbonic anhydrase 1	Rattus norvegicus	113-116
20089134-3	2010	The major transport protein responsible for uptake of iron is divalent metal transporter 1 (DMT1) and recent studies demonstrate that the 1B species is regulated post-translationally by degradation via the proteasomal pathway.	Iron	54-58	solute carrier family 11 member 2	Homo sapiens	62-90
15248564-7	2004	When the rats were exposed to 5-min ischemia 2 days before lethal 20-min ischemia, the deposition of iron in the CA1 region of the hippocampus and also in the corpus striatum pars dorsolateralis was decreased and produced a minimal number of iron-containing cells between the second and the 8th week of recirculation.	Iron	242-246	carbonic anhydrase 1	Rattus norvegicus	113-116
15003819-2	2004	Considering the well-known phenotypic variability of this disease, especially between men and women, it is important to define factors susceptible to modulate hepatic hepcidin expression and, consequently, to influence the development of iron overload in HFE-1 hemochromatosis.	Iron	238-242	hepcidin antimicrobial peptide	Homo sapiens	167-175
15003822-4	2004	We found that Fes-induced macrophage differentiation correlated with activation of the ets family transcription factor PU.1, which is essential for macrophage development.	Iron	14-17	Spi-1 proto-oncogene	Homo sapiens	119-123
20089134-3	2010	The major transport protein responsible for uptake of iron is divalent metal transporter 1 (DMT1) and recent studies demonstrate that the 1B species is regulated post-translationally by degradation via the proteasomal pathway.	Iron	54-58	solute carrier family 11 member 2	Homo sapiens	92-96
20401791-8	2010	HUVEC incubated with glycated protein (GFBS) either alone or combined with iron chelate showed a significant (p &lt; 0.001) elevation of LPO accompanied by depletion of superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased GST activities.	Iron	75-79	glutathione S-transferase kappa 1	Homo sapiens	335-338
15022188-2	2004	We show that homozygote Cys212Tyr parkin mutation in AR-JP patients renders lymphocytes sensitive to dopamine, iron and hydrogen peroxide stimuli.	Iron	111-115	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	53-58
20152801-3	2010	We tested the hypothesis that divalent metal-ion transporter-1 (DMT1)-the principal or only mechanism by which nonheme iron is taken up at the intestinal brush border-is shared also by calcium.	Iron	119-123	solute carrier family 11 member 2	Homo sapiens	30-62
15022188-5	2004	These results may contribute to understanding the relationship between genetic and environmental factors and iron in AR-JP.	Iron	86-90	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	117-122
20152801-3	2010	We tested the hypothesis that divalent metal-ion transporter-1 (DMT1)-the principal or only mechanism by which nonheme iron is taken up at the intestinal brush border-is shared also by calcium.	Iron	119-123	solute carrier family 11 member 2	Homo sapiens	64-68
20152801-8	2010	The alkaline-earth metal ions Ba2+, Sr2+, and Mg2+ also inhibited DMT1-mediated iron-transport activity.	Iron	80-84	solute carrier family 11 member 2	Homo sapiens	66-70
20232409-0	2010	Regulatory mechanisms of intestinal iron absorption-uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	101-105
20232409-3	2010	High iron levels induce the synthesis of hepcidin, which in turn decreases circulating iron by inhibiting its recycling from macrophages and its absorption at the intestine.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	41-49
14648120-5	2004	This cDNA clone, designated RIT1 for root iron transporter, encodes a 348 amino acid polypeptide with eight putative membrane-spanning domains that is induced under Fe deficiency and can functionally complement yeast mutants defective in high- and low-affinity Fe transport.	Iron	165-167	tRNA A64-2'-O-ribosylphosphate transferase	Saccharomyces cerevisiae S288C	28-32
20232409-3	2010	High iron levels induce the synthesis of hepcidin, which in turn decreases circulating iron by inhibiting its recycling from macrophages and its absorption at the intestine.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	41-49
14648120-8	2004	These findings suggest that, in typical agricultural soils, RIT1 functions primarily as a high-affinity Fe(2+) transporter that mediates root Fe acquisition.	Iron	104-106	tRNA A64-2'-O-ribosylphosphate transferase	Saccharomyces cerevisiae S288C	60-64
20020468-6	2010	Furthermore, downstream products of HO-1, bilirubin, carbon monoxide, and iron, are involved in the inhibitory action of HO-1.	Iron	74-78	heme oxygenase 1	Homo sapiens	121-125
14766298-1	2004	Melanotransferrin, also named p97, belongs to the transferrin-like group of iron-binding proteins.	Iron	76-80	melanotransferrin	Homo sapiens	0-17
14766298-1	2004	Melanotransferrin, also named p97, belongs to the transferrin-like group of iron-binding proteins.	Iron	76-80	melanotransferrin	Homo sapiens	30-33
14977358-0	2004	Regulation of p27(Kip1) by intracellular iron levels.	Iron	41-45	interferon alpha inducible protein 27	Homo sapiens	14-17
14977358-0	2004	Regulation of p27(Kip1) by intracellular iron levels.	Iron	41-45	cyclin dependent kinase inhibitor 1B	Homo sapiens	18-22
14977358-12	2004	Using an IPTG-responsive construct to artificially raise p27(Kip1) levels blocked the ability of iron supplementation to promote S phase entry.	Iron	97-101	interferon alpha inducible protein 27	Homo sapiens	57-60
14977358-12	2004	Using an IPTG-responsive construct to artificially raise p27(Kip1) levels blocked the ability of iron supplementation to promote S phase entry.	Iron	97-101	cyclin dependent kinase inhibitor 1B	Homo sapiens	61-65
14977358-13	2004	Thus it appears that p27(Kip1) is a mediator of G1 arrest in iron depleted Swiss 3T3 fibroblasts.	Iron	61-65	interferon alpha inducible protein 27	Homo sapiens	21-24
14977358-13	2004	Thus it appears that p27(Kip1) is a mediator of G1 arrest in iron depleted Swiss 3T3 fibroblasts.	Iron	61-65	cyclin dependent kinase inhibitor 1B	Homo sapiens	25-29
14724150-0	2004	Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.	Iron	92-96	ceruloplasmin	Mus musculus	45-56
14724150-1	2004	BACKGROUND: Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes.	Iron	90-94	ceruloplasmin	Mus musculus	40-51
15104207-2	2004	Amount of iron release from the heme pocket of myoglobin was found to be directly related with the extent of glycation.	Iron	10-14	myoglobin	Homo sapiens	47-56
15104207-10	2004	However, besides free iron-mediated free radical reactions, role of iron of higher oxidation states, formed during interaction of H2O2 with myoglobin might also be involved in oxidative degradation processes.	Iron	22-26	myoglobin	Homo sapiens	140-149
15104207-10	2004	However, besides free iron-mediated free radical reactions, role of iron of higher oxidation states, formed during interaction of H2O2 with myoglobin might also be involved in oxidative degradation processes.	Iron	68-72	myoglobin	Homo sapiens	140-149
14768003-3	2004	The current study investigated the duodenal expression of the iron transport molecules divalent metal transporter 1 (DMT1 [IRE]), iron-regulated gene 1 (Ireg1 [ferroportin]), hephaestin, and duodenal cytochrome b (Dyctb) in 46 patients with cirrhosis and 20 control subjects.	Iron	62-66	solute carrier family 11 member 2	Homo sapiens	117-121
14768003-5	2004	Expression of DMT1 and Ireg1 was increased 1.5 to 3-fold in subjects with cirrhosis compared with iron-replete control subjects.	Iron	98-102	solute carrier family 11 member 2	Homo sapiens	14-18
14768003-5	2004	Expression of DMT1 and Ireg1 was increased 1.5 to 3-fold in subjects with cirrhosis compared with iron-replete control subjects.	Iron	98-102	solute carrier family 40 member 1	Homo sapiens	23-28
14768003-12	2004	Increased expression of DMT1 may play an important role in the pathogenesis of cirrhosis-associated hepatic iron overload.	Iron	108-112	solute carrier family 11 member 2	Homo sapiens	24-28
14734750-9	2004	Finally, we found that the triptophan catabolite picolinic acid and the iron chelator desferrioxamine, which mimic hypoxia in the induction of gene expression, differentially regulated the expression of MCP-1.	Iron	72-76	C-C motif chemokine ligand 2	Homo sapiens	203-208
14747685-8	2004	The high-iron diet reduced GPx (P &lt; 0.0001), CAT (P &lt; 0.0005), SOD (P &lt; 0.05), and GST (P &lt; 0.005) activities regardless of ascorbic acid supplementation.	Iron	9-13	hematopoietic prostaglandin D synthase	Mus musculus	92-95
14530973-7	2004	DMT1 is up-regulated dramatically in the intestine by dietary iron restriction and, despite high serum iron levels, is not appropriately down-regulated in hereditary hemochromatosis.	Iron	62-66	solute carrier family 11 member 2	Homo sapiens	0-4
14530973-7	2004	DMT1 is up-regulated dramatically in the intestine by dietary iron restriction and, despite high serum iron levels, is not appropriately down-regulated in hereditary hemochromatosis.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	0-4
15003923-6	2004	Positive correlations of serum ferritin with the number of CD8 (T-suppressor cell) and of serum iron with CD56 (natural killer, NK cells) were observed in men.	Iron	96-100	neural cell adhesion molecule 1	Homo sapiens	106-110
14976405-0	2004	Heat shock protein 90 recognized as an iron-binding protein associated with the plasma membrane of HeLa cells.	Iron	39-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-21
14976405-3	2004	Employing an iron-binding assay and mass spectrometric analysis, we have identified human Hsp90 as an iron-binding protein in membrane protein preparations of human HeLa cells.	Iron	13-17	heat shock protein 90 alpha family class A member 1	Homo sapiens	90-95
14976405-3	2004	Employing an iron-binding assay and mass spectrometric analysis, we have identified human Hsp90 as an iron-binding protein in membrane protein preparations of human HeLa cells.	Iron	102-106	heat shock protein 90 alpha family class A member 1	Homo sapiens	90-95
14976405-5	2004	The iron-binding assay with purified human Hsp90 confirmed iron binding by Hsp90.	Iron	4-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	43-48
14976405-5	2004	The iron-binding assay with purified human Hsp90 confirmed iron binding by Hsp90.	Iron	4-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	75-80
14976405-5	2004	The iron-binding assay with purified human Hsp90 confirmed iron binding by Hsp90.	Iron	59-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	43-48
20087600-9	2010	We identified a mutation in the AtNAP1 gene, which encodes a subunit of the complex for iron-sulfur cluster formation.	Iron	88-92	transcription activator	Arabidopsis thaliana	32-38
14976405-5	2004	The iron-binding assay with purified human Hsp90 confirmed iron binding by Hsp90.	Iron	59-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	75-80
14976405-6	2004	Thus we suggest that Hsp90 is an iron-binding protein associated with the plasma membrane.	Iron	33-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	21-26
19783267-3	2010	We propose that cytokine- and hepcidin-mediated iron delocalisation, a principal mechanism in the anaemia of inflammation, plays an important role in the aetiology of malarial anaemia, and can explain some of the clinical and laboratory findings.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	30-38
15471342-4	2004	One surprising result, which will be stressed in the discussion, is the observation of a distinct product state vibrational coherence (the iron-histidine stretching vibration of deoxy Mb at 220 cm(-1)) that depends upon the presence of pump field interactions having a wavelength mismatch that is equal to the 220 cm(-1) vibrational frequency.	Iron	139-143	myoglobin	Homo sapiens	184-186
20026331-1	2010	Hepcidin is a small acute phase peptide that regulates iron absorption.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
14684575-12	2004	In enterocytes from iron deficient rats, ferroportin was expressed along the brush border where it colocalised with lactase.	Iron	20-24	lactase	Rattus norvegicus	116-123
19961840-2	2010	To delineate the underlying molecular mechanisms, we recently found that Rhizoma Chuanxiong extract significantly induced heme oxygenase-1 (HO-1), an enzyme that degrades intracellular heme into three bioactive products: biliverdin, carbon monoxide and free iron.	Iron	258-262	heme oxygenase 1	Homo sapiens	122-138
15655262-4	2004	Recent observations, that iron induces aggregation of inert alpha-synuclein to toxic aggregates, have reinforced the critical role of iron in oxidative stress-induced pathogenesis of DA neuron degeneration and protein degradation via ubiquitination.	Iron	26-30	synuclein, alpha	Mus musculus	60-75
15655262-4	2004	Recent observations, that iron induces aggregation of inert alpha-synuclein to toxic aggregates, have reinforced the critical role of iron in oxidative stress-induced pathogenesis of DA neuron degeneration and protein degradation via ubiquitination.	Iron	134-138	synuclein, alpha	Mus musculus	60-75
19961840-2	2010	To delineate the underlying molecular mechanisms, we recently found that Rhizoma Chuanxiong extract significantly induced heme oxygenase-1 (HO-1), an enzyme that degrades intracellular heme into three bioactive products: biliverdin, carbon monoxide and free iron.	Iron	258-262	heme oxygenase 1	Homo sapiens	140-144
14770366-2	2004	The classical view of iron metabolism has been challenged over the past ten years by the discovery of several new proteins, mostly Fe (II) iron transporters, enzymes with ferro-oxydase (hephaestin or ceruloplasmin) or ferri-reductase (Dcytb) activity or regulatory proteins like HFE and hepcidin.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	287-295
14770366-4	2004	Intestinal iron absorption by mature duodenal enterocytes requires Fe (III) iron reduction by Dcytb and Fe (II) iron transport through apical membranes by the iron transporter Nramp2/DMT1.	Iron	11-15	solute carrier family 11 member 2	Homo sapiens	176-182
20063986-10	2010	Significantly, serum iron concentration was remarkably reduced as compared with that of h-ahsp(-)/beta(IVS-2-654+) mice (43.2 +/- 14.9 vs. 82.4 +/- 12.9 microM), and iron deposition in the liver was decreased in h-ahsp(+)/beta(IVS-2-654+) mice.	Iron	21-25	alpha hemoglobin stabilizing protein	Mus musculus	214-218
14770366-4	2004	Intestinal iron absorption by mature duodenal enterocytes requires Fe (III) iron reduction by Dcytb and Fe (II) iron transport through apical membranes by the iron transporter Nramp2/DMT1.	Iron	11-15	solute carrier family 11 member 2	Homo sapiens	183-187
14770366-9	2004	Signalling between iron stores in the liver and both duodenal enterocytes and macrophages is mediated by hepcidin, a circulating peptide synthesized by the liver and secreted into the plasma.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	105-113
20018808-8	2010	Expression of an alternative route of Fe absorption, solute carrier family 39 member 14 (SLC39A14), was downregulated in the intestine of pigs fed high dietary Fe.	Iron	38-40	zinc transporter ZIP14	Sus scrofa	53-87
14770366-10	2004	Hepcidin expression is stimulated in response to iron overload or inflammation, and down regulated by anemia and hypoxia.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
14770366-11	2004	Hepcidin deficiency leads to iron overload and hepcidin overexpression to anemia.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
20018808-8	2010	Expression of an alternative route of Fe absorption, solute carrier family 39 member 14 (SLC39A14), was downregulated in the intestine of pigs fed high dietary Fe.	Iron	38-40	zinc transporter ZIP14	Sus scrofa	89-97
14770366-12	2004	Hepcidin synthesis in response to iron overload seems to be controlled by the HFE molecule.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
20018808-8	2010	Expression of an alternative route of Fe absorption, solute carrier family 39 member 14 (SLC39A14), was downregulated in the intestine of pigs fed high dietary Fe.	Iron	160-162	zinc transporter ZIP14	Sus scrofa	53-87
14770366-13	2004	Patients with hereditary hemochromatosis due to HFE mutation have impaired hepcidin synthesis and forced expression of an hepcidin transgene in HFE deficient mice prevents iron overload.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	122-130
19818853-3	2010	Here, we tested potential neuroprotection via genetic expression of the iron chelator human ferritin heavy chain (H-ferritin).	Iron	72-76	ferritin heavy chain 1	Homo sapiens	92-112
19906149-10	2010	In particular, an increase in the abundance of ferritin proteins effectively sequestered more iron and prevented excess free iron in the elongation zone under water stress.	Iron	94-98	ferritin-1, chloroplastic	Glycine max	47-55
15050106-0	2004	Is hepcidin an iron cluster peptide?	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	3-11
19906149-10	2010	In particular, an increase in the abundance of ferritin proteins effectively sequestered more iron and prevented excess free iron in the elongation zone under water stress.	Iron	125-129	ferritin-1, chloroplastic	Glycine max	47-55
19880490-3	2010	The single-nucleotide polymorphism most strongly associated with lower serum iron concentration was rs4820268 (P = 5.12 x 10(-9)), located in exon 13 of the transmembrane protease serine 6 (TMPRSS6) gene, an enzyme that promotes iron absorption and recycling by inhibiting hepcidin antimicrobial peptide transcription.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	273-281
15381278-3	2004	We observed a general correlation between levels of DMT1, and iron staining.	Iron	62-66	solute carrier family 11 member 2	Homo sapiens	52-56
15381278-7	2004	The high levels of DMT1 expression in some of the nuclei of the basal ganglia, particularly the caudate nucleus, putamen, and substantia nigra pars reticulata, may account for the high levels of iron in these regions.	Iron	195-199	solute carrier family 11 member 2	Homo sapiens	19-23
19683083-1	2010	Hepcidin, a liver peptide hormone, is the central regulator of iron homeostasis.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
19683083-2	2010	Hepcidin synthesis is modulated by iron stores, so that iron repletion increases its levels to prevent pathological overload, while iron deficiency strongly inhibits hepcidin to allow an increase in iron absorption from duodenal cells.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
14504288-3	2003	The small Maf proteins appear to be critical regulators of heme oxygenase (HO)-1, an anti-oxidant defense enzyme that degrades heme into iron, carbon monoxide, and biliverdin.	Iron	137-141	heme oxygenase 1	Homo sapiens	59-80
19683083-2	2010	Hepcidin synthesis is modulated by iron stores, so that iron repletion increases its levels to prevent pathological overload, while iron deficiency strongly inhibits hepcidin to allow an increase in iron absorption from duodenal cells.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
19683083-2	2010	Hepcidin synthesis is modulated by iron stores, so that iron repletion increases its levels to prevent pathological overload, while iron deficiency strongly inhibits hepcidin to allow an increase in iron absorption from duodenal cells.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
19683083-3	2010	The emerging pivotal role of hepcidin in iron homeostasis, along with its important links with basic pathways like inflammation, makes the availability of an accurate hepcidin assay as a potentially powerful investigative tool to improve our understanding as well as our diagnostic/prognostic capabilities in many human diseases.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	29-37
20606413-9	2010	CONCLUSION: Fluctuations in Ret-He and DF-HYPO XE have to be taken into account when these parameters are used for the assessment of iron-deficient states.	Iron	133-137	ret proto-oncogene	Homo sapiens	28-31
12907459-0	2003	Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	46-59
12907459-0	2003	Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	61-65
12907459-1	2003	The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes.	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	18-30
12907459-1	2003	The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes.	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	32-36
12907459-1	2003	The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes.	Iron	143-147	solute carrier family 40 member 1	Homo sapiens	18-30
12907459-1	2003	The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes.	Iron	143-147	solute carrier family 40 member 1	Homo sapiens	32-36
12907459-2	2003	To gain insight into FPN1"s role in macrophage iron metabolism, we examined the effect of iron status and erythrophagocytosis on FPN1 expression in J774 macrophages.	Iron	47-51	solute carrier family 40 member 1	Homo sapiens	21-25
12907459-3	2003	Northern analysis indicated that FPN1 mRNA levels decreased with iron depletion and increased on iron loading.	Iron	65-69	solute carrier family 40 member 1	Homo sapiens	33-37
12907459-3	2003	Northern analysis indicated that FPN1 mRNA levels decreased with iron depletion and increased on iron loading.	Iron	97-101	solute carrier family 40 member 1	Homo sapiens	33-37
12907459-4	2003	The iron-induced induction of FPN1 mRNA was blocked by actinomycin D, suggesting that transcriptional control was responsible for this effect.	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	30-34
12907459-7	2003	Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	26-30
12907459-7	2003	Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	101-105
12907459-7	2003	Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron.	Iron	149-153	solute carrier family 40 member 1	Homo sapiens	26-30
12907459-7	2003	Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron.	Iron	149-153	solute carrier family 40 member 1	Homo sapiens	101-105
12907459-8	2003	Comparative Northern analyses of iron-related genes after erythrophagocytosis revealed a 16-fold increase in FPN1 levels after 3 hours, a 10-fold increase in heme oxygenase-1 (HO-1) after 3 hours, a 2-fold increase in natural resistance macrophage-associated protein 1 (Nramp1) levels after 6 hours, but no change in divalent metal ion transporter 1 (DMT1) levels.	Iron	33-37	solute carrier family 40 member 1	Homo sapiens	109-113
12907459-8	2003	Comparative Northern analyses of iron-related genes after erythrophagocytosis revealed a 16-fold increase in FPN1 levels after 3 hours, a 10-fold increase in heme oxygenase-1 (HO-1) after 3 hours, a 2-fold increase in natural resistance macrophage-associated protein 1 (Nramp1) levels after 6 hours, but no change in divalent metal ion transporter 1 (DMT1) levels.	Iron	33-37	heme oxygenase 1	Homo sapiens	158-174
12907459-8	2003	Comparative Northern analyses of iron-related genes after erythrophagocytosis revealed a 16-fold increase in FPN1 levels after 3 hours, a 10-fold increase in heme oxygenase-1 (HO-1) after 3 hours, a 2-fold increase in natural resistance macrophage-associated protein 1 (Nramp1) levels after 6 hours, but no change in divalent metal ion transporter 1 (DMT1) levels.	Iron	33-37	solute carrier family 11 member 2	Homo sapiens	317-349
12907459-8	2003	Comparative Northern analyses of iron-related genes after erythrophagocytosis revealed a 16-fold increase in FPN1 levels after 3 hours, a 10-fold increase in heme oxygenase-1 (HO-1) after 3 hours, a 2-fold increase in natural resistance macrophage-associated protein 1 (Nramp1) levels after 6 hours, but no change in divalent metal ion transporter 1 (DMT1) levels.	Iron	33-37	solute carrier family 11 member 2	Homo sapiens	351-355
12907459-9	2003	The rapid and strong induction of FPN1 expression after erythrophagocytosis suggests that FPN1 plays a role in iron recycling.	Iron	111-115	solute carrier family 40 member 1	Homo sapiens	34-38
12907459-9	2003	The rapid and strong induction of FPN1 expression after erythrophagocytosis suggests that FPN1 plays a role in iron recycling.	Iron	111-115	solute carrier family 40 member 1	Homo sapiens	90-94
14745458-1	2003	OBJECTIVE: This study was undertaken to assess the role of p97 (also known as melanotransferrin) in the transfer of iron into the brain, because the passage of most large molecules is limited by the presence of the blood-brain barrier, including that of the serum iron transporter transferrin.	Iron	116-120	melanotransferrin	Homo sapiens	59-62
14745458-1	2003	OBJECTIVE: This study was undertaken to assess the role of p97 (also known as melanotransferrin) in the transfer of iron into the brain, because the passage of most large molecules is limited by the presence of the blood-brain barrier, including that of the serum iron transporter transferrin.	Iron	116-120	melanotransferrin	Homo sapiens	78-95
14745458-4	2003	We also provide evidence that p97 transports iron into the brain more efficiently than transferrin.	Iron	45-49	melanotransferrin	Homo sapiens	30-33
14745458-5	2003	CONCLUSIONS: These data support the idea that p97 is an important iron transporter across the blood-brain barrier in normal physiology and possibly in neurodegenerative diseases, such as Alzheimer disease, in which iron homeostasis in the brain becomes disrupted.	Iron	66-70	melanotransferrin	Homo sapiens	46-49
12952974-0	2003	Role of ceruloplasmin in macrophage iron efflux during hypoxia.	Iron	36-40	ceruloplasmin	Homo sapiens	8-21
14649840-1	2003	Heating a toluene solution of Cp*(CO)(C5H5N)FeSiMe2NPh2 led to insertion of pyridine into the iron-silicon bond to form Cp*(CO)Fe[eta3(C,C,C)-C5H5NSiMe2NPh2].	Iron	94-98	neurexophilin 2	Homo sapiens	51-55
14638395-1	2003	Lactoferrin (LF) is an iron-binding protein that is found in milk and other mammalian secretions.	Iron	23-27	lactotransferrin	Bos taurus	0-11
14562166-1	2003	INTRODUCTION: Heme oxygenase (HO) isoforms, HO-1, and HO-2, are responsible for heme breakdown to iron and carbon monoxide (CO).	Iron	98-102	heme oxygenase 1	Homo sapiens	44-48
14966382-7	2003	Qualitative and quantitative immunohistochemical analyses of dendritic structure and growth using microtubule-associated protein-2 as an index showed that iron-deficient P15 pups have truncated apical dendritic morphology in CA1 and a persistence of an immature apical dendritic pattern at P65.	Iron	155-159	microtubule-associated protein 2	Rattus norvegicus	98-130
14966382-7	2003	Qualitative and quantitative immunohistochemical analyses of dendritic structure and growth using microtubule-associated protein-2 as an index showed that iron-deficient P15 pups have truncated apical dendritic morphology in CA1 and a persistence of an immature apical dendritic pattern at P65.	Iron	155-159	cyclin-dependent kinase inhibitor 2B	Rattus norvegicus	170-173
14966382-7	2003	Qualitative and quantitative immunohistochemical analyses of dendritic structure and growth using microtubule-associated protein-2 as an index showed that iron-deficient P15 pups have truncated apical dendritic morphology in CA1 and a persistence of an immature apical dendritic pattern at P65.	Iron	155-159	carbonic anhydrase 1	Rattus norvegicus	225-228
14966382-8	2003	These results demonstrate that perinatal iron deficiency disrupts developmental processes in the hippocampal subarea CA1 and that these changes persist despite iron repletion.	Iron	41-45	carbonic anhydrase 1	Rattus norvegicus	117-120
14573629-1	2003	The iron-binding protein lactoferrin is a ubiquitous and abundant constituent of human exocrine secretions.	Iron	4-8	lactotransferrin	Bos taurus	25-36
14573629-2	2003	Lactoferrin inhibits bacterial growth by sequestering essential iron and also exhibits non-iron-dependent antibacterial, antifungal, antiviral, antitumor, anti-inflammatory, and immunoregulatory activities.	Iron	64-68	lactotransferrin	Bos taurus	0-11
14573629-2	2003	Lactoferrin inhibits bacterial growth by sequestering essential iron and also exhibits non-iron-dependent antibacterial, antifungal, antiviral, antitumor, anti-inflammatory, and immunoregulatory activities.	Iron	91-95	lactotransferrin	Bos taurus	0-11
14573629-3	2003	All of these non-iron-dependent activities are mediated by the highly charged N terminus of lactoferrin.	Iron	17-21	lactotransferrin	Bos taurus	92-103
14573629-6	2003	The two lactoferrin variants exhibited nearly identical iron-binding and iron-releasing activities and equivalent bactericidal activities against a strain of the gram-negative bacterium Actinobacillus actinomycetemcomitans.	Iron	56-60	lactotransferrin	Bos taurus	8-19
14573629-6	2003	The two lactoferrin variants exhibited nearly identical iron-binding and iron-releasing activities and equivalent bactericidal activities against a strain of the gram-negative bacterium Actinobacillus actinomycetemcomitans.	Iron	73-77	lactotransferrin	Bos taurus	8-19
14603992-2	2003	Iron disturbed CD2 expression on T-cells, cell-mediated immunity by Th1 cells and monocyte functions including phagocytosis and natural killer activity.	Iron	0-4	CD2 molecule	Homo sapiens	15-18
14531706-10	2003	In the complex [LFeCrFeL](+), due to a higher energy of the magnetic orbital on the central Cr ion than on the terminal Fe ones, the spin 3/2 and the single unpaired a(1) electron are almost localized at the chromium center in the ground state.	Iron	17-19	spindlin family member 3	Homo sapiens	133-141
14500582-5	2003	In the anemia of chronic disease, measurements of plasma cytokines and iron metabolism regulators such as hepcidin (when available) may be helpful in the characterization of the pathophysiologic basis of this condition.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	106-114
12973678-2	2003	Although DMT1 has been functionally linked to duodenal absorption and cellular utilisation of iron hardly anything is known about its distribution and potential role within the human glandular system.	Iron	94-98	doublesex and mab-3 related transcription factor 1	Homo sapiens	9-13
14512884-8	2003	An increase in Tf-Fe uptake by NTfR1-mediated pathway was correlated with an increase in TfR2-alpha protein expression but not TfR2-alpha mRNA.	Iron	18-20	transferrin receptor 2	Homo sapiens	89-93
14512884-9	2003	In conclusion, TfR2-alpha protein is likely to have a role in the mediation of Tf-Fe uptake by the NTfR1 process by HuH7 hepatoma cell in proliferating and stationary stages of growth.	Iron	82-84	transferrin receptor 2	Homo sapiens	15-19
14534484-0	2003	[Hepcidin, the conductor of iron homeostasis].	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	1-9
12730111-1	2003	Hephaestin is a membrane-bound multicopper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation.	Iron	69-73	ceruloplasmin	Mus musculus	43-54
12730114-0	2003	Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	133-140
12949720-2	2003	Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transporter-1 and FPN1, respectively, to transfer iron from the duodenal lumen to the circulation.	Iron	163-167	solute carrier family 40 member 1	Homo sapiens	131-135
12949720-6	2003	Spearman rank correlations showed that Dcytb, hephaestin, FPN1, and DMT1 mRNA expression are positively related to each other independently of the underlying disease, which ensures an efficient transepithelial transport of absorbed iron.	Iron	232-236	solute carrier family 40 member 1	Homo sapiens	58-62
12949720-6	2003	Spearman rank correlations showed that Dcytb, hephaestin, FPN1, and DMT1 mRNA expression are positively related to each other independently of the underlying disease, which ensures an efficient transepithelial transport of absorbed iron.	Iron	232-236	solute carrier family 11 member 2	Homo sapiens	68-72
13678532-2	2003	Heme oxygenase (HO) is a microsomal enzyme that catalyzes the degradation of heme into biliverdin, which is subsequently reduced to bilirubin, free iron, and carbon monoxide, and induction of HO-1 is potentially associated with cellular protection, especially against oxidative insults.	Iron	148-152	heme oxygenase 1	Homo sapiens	192-196
12950389-5	2003	The level of p53 mRNA decreased significantly under iron deprivation in sensitive cells, but it did not change in resistant cells.	Iron	52-56	transformation related protein 53, pseudogene	Mus musculus	13-16
12950389-6	2003	On the contrary, the level of the p53 protein under iron deprivation was slightly increased in sensitive cells while it was not changed in resistant cells.	Iron	52-56	transformation related protein 53, pseudogene	Mus musculus	34-37
20066043-1	2010	The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, and tissue iron distribution.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	28-36
12909459-1	2003	Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the induction of ferritin, an iron-binding protein).	Iron	144-148	heme oxygenase 1	Homo sapiens	0-21
20066043-1	2010	The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, and tissue iron distribution.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	28-36
20066043-1	2010	The hepatic peptide hormone hepcidin regulates dietary iron absorption, plasma iron concentrations, and tissue iron distribution.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	28-36
12907830-7	2003	Although the ceruloplasmin levels were depleted (48.9 mg/dL vs 41.4 mg/dL, p=0.035) during ferrous iron treatment, the copper and zinc levels remained unchanged.	Iron	99-103	ceruloplasmin	Homo sapiens	13-26
12907830-10	2003	In conclusion, our data showed that copper and ceruloplasmin metabolisms were affected by ferrous iron supplementation, whereas ferric iron kept them to normal levels of zinc, possibly by affecting their absorption.	Iron	90-102	ceruloplasmin	Homo sapiens	47-60
20066043-2	2010	Hepcidin acts by causing the degradation of its receptor, the cellular iron exporter ferroportin.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
20066043-5	2010	Deficient production of hepcidin causes systemic iron overload in iron-loading anemias such as beta-thalassemia; whereas hepcidin excess contributes to the development of anemia in inflammatory disorders and chronic kidney disease, and may cause erythropoietin resistance.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	24-32
20066043-5	2010	Deficient production of hepcidin causes systemic iron overload in iron-loading anemias such as beta-thalassemia; whereas hepcidin excess contributes to the development of anemia in inflammatory disorders and chronic kidney disease, and may cause erythropoietin resistance.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	24-32
20862391-5	2010	GLRX5 is involved in the production and ABCB7 in the export of an unknown factor that may function as a gauge of mitochondrial iron status, which may indirectly modulate activity of iron regulatory proteins (IRPs).	Iron	127-131	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	0-5
12844390-11	2003	Indicators of Fe status negatively correlated with CD3 FI (r-0.23), but positively correlated with CD28 FI (r&lt; or =0.44; P&lt;0.05).	Iron	14-16	CD28 antigen	Mus musculus	99-103
12870790-3	2003	However, iron-free apo-lactoferrin (bovine and human) and 66% iron-saturated bovine lactoferrin dramatically slowed the growth of E. coli O157:H7 in single culture experiments, while 98% iron-saturated preparations had no effect.	Iron	9-13	lactotransferrin	Bos taurus	23-34
20862391-7	2010	GLRX5 may also provide Fe-S cofactor for ferrochelatase, the last enzyme in heme synthesis.	Iron	23-25	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	0-5
12870790-3	2003	However, iron-free apo-lactoferrin (bovine and human) and 66% iron-saturated bovine lactoferrin dramatically slowed the growth of E. coli O157:H7 in single culture experiments, while 98% iron-saturated preparations had no effect.	Iron	62-66	lactotransferrin	Bos taurus	84-95
12870790-3	2003	However, iron-free apo-lactoferrin (bovine and human) and 66% iron-saturated bovine lactoferrin dramatically slowed the growth of E. coli O157:H7 in single culture experiments, while 98% iron-saturated preparations had no effect.	Iron	62-66	lactotransferrin	Bos taurus	84-95
20484891-1	2010	BACKGROUND/AIM: Hepcidin could be one of the most important regulators for iron metabolism in patients on maintenance hemodialysis (MHD).	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	16-24
12870790-4	2003	In coculture experiments of B. infantis and E. coli, the iron-limited preparations of lactoferrin also slowed the growth of the latter without inhibiting the bifidobacteria.	Iron	57-61	lactotransferrin	Bos taurus	86-97
12870790-5	2003	These results suggest that lactoferrin in iron-limited forms may have the potential to be combined with probiotic bacteria in biotherapeutic products, which could help balance human gut microflora and limit the overgrowth of certain enteric microorganisms.	Iron	42-46	lactotransferrin	Bos taurus	27-38
20484891-2	2010	The factors affecting serum hepcidin levels were evaluated among indexes of anemia, iron metabolism, or inflammation, as well as the dose of erythropoietin.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	28-36
12781484-7	2003	One group, orf1, 2, 5, 6-8, 12-15, 19, and 20 (which includes all the vap genes), was induced at 37 degrees C, mostly by low iron, and to a lesser extent by the synergy of low calcium and pH=5.	Iron	125-129	ORF 1	Rhodococcus equi	11-15
20027482-1	2010	Mutations of the HFE and TFR2 genes have been associated with iron overload.	Iron	62-66	transferrin receptor 2	Homo sapiens	25-29
19954435-8	2010	The inhibitor binds to the human heme oxygenase-1 distal pocket through the coordination of heme iron by the N4 in the triazole moiety, whereas the phenyl group is stabilized by hydrophobic interactions from residues within the binding pocket.	Iron	97-101	heme oxygenase 1	Homo sapiens	33-49
12646040-1	2003	Divalent-metal transporter 1 (DMT1) is involved in the intestinal iron absorption and in iron transport in the transferrin cycle.	Iron	66-70	solute carrier family 11 member 2	Homo sapiens	0-28
12646040-1	2003	Divalent-metal transporter 1 (DMT1) is involved in the intestinal iron absorption and in iron transport in the transferrin cycle.	Iron	66-70	solute carrier family 11 member 2	Homo sapiens	30-34
12646040-1	2003	Divalent-metal transporter 1 (DMT1) is involved in the intestinal iron absorption and in iron transport in the transferrin cycle.	Iron	89-93	solute carrier family 11 member 2	Homo sapiens	0-28
12646040-1	2003	Divalent-metal transporter 1 (DMT1) is involved in the intestinal iron absorption and in iron transport in the transferrin cycle.	Iron	89-93	solute carrier family 11 member 2	Homo sapiens	30-34
23496110-4	2010	The liver is the major storage organ for iron and produces transferrin and hepcidin, which help to regulate iron.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	75-83
12957294-9	2003	Ferrous iron also transiently decreased cytoplasmic I-kappa B-alpha (IkappaB-alpha), with concomitant increases in nuclear p65 protein and DNA binding of p65/p50.	Iron	0-12	NFKB inhibitor alpha	Rattus norvegicus	52-67
12957294-9	2003	Ferrous iron also transiently decreased cytoplasmic I-kappa B-alpha (IkappaB-alpha), with concomitant increases in nuclear p65 protein and DNA binding of p65/p50.	Iron	0-12	NFKB inhibitor alpha	Rattus norvegicus	69-82
23496110-6	2010	In the last 13 years, the discoveries of hepcidin and the HFE gene have propelled our understanding of iron metabolism and iron overload disorders.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	41-49
19786029-0	2010	Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo.	Iron	0-4	bone morphogenetic protein 6	Mus musculus	27-53
12704646-1	2003	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme to carbon monoxide (CO), iron, and biliverdin.	Iron	83-87	heme oxygenase 1	Homo sapiens	0-16
12704646-1	2003	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme to carbon monoxide (CO), iron, and biliverdin.	Iron	83-87	heme oxygenase 1	Homo sapiens	18-22
19786029-1	2010	BACKGROUND &amp; AIMS: Recent studies identified bone morphogenic protein 6 (BMP6) as a key regulator of hepatic hepcidin expression and iron metabolism, but the cellular source of BMP6 and the reason for its specific effect on hepatocytes are unknown.	Iron	137-141	bone morphogenetic protein 6	Mus musculus	49-75
20414466-1	2010	The hepatic iron regulator hormone hepcidin consists, in its mature form, of 25 amino acids, but two other isoforms, hepcidin-20 and hepcidin-22, have been reported, whose biological meaning remains poorly understood.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	35-43
12962278-5	2003	In the presence of transferrin, low K+ enhanced cellular uptake of iron.	Iron	67-71	inhibitor of carbonic anhydrase	Canis lupus familiaris	19-30
12962278-9	2003	The effect of transferrin is mediated by increased iron transport and reactive oxygen species activity.	Iron	51-55	inhibitor of carbonic anhydrase	Canis lupus familiaris	14-25
20619018-2	2010	These defects are located in genes that encode for the cellular iron importing protein Divalent Metal Transporter 1 (DMT1), the iron exporting protein ferroportin, the mitochondrial enzyme glutaredoxin-5 and the hepatocyte membrane protein matriptase-2.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	87-115
12753316-9	2003	Serum TRX was also higher in the patients receiving weekly iron supplement with HCV infection (135.3 +/- 10.2 ng/mL vs. 110.2 +/- 3.9 ng/mL, P = 0.06) and without HCV infection (91.8 +/- 12.1 ng/mL vs. 65.2 +/- 2.7 ng/mL, P &lt; 0.01).	Iron	59-63	thioredoxin	Homo sapiens	6-9
12753316-12	2003	TRX increased with serum ferritin in HCV-infected patients and further increased by iron infusion.	Iron	84-88	thioredoxin	Homo sapiens	0-3
20619018-2	2010	These defects are located in genes that encode for the cellular iron importing protein Divalent Metal Transporter 1 (DMT1), the iron exporting protein ferroportin, the mitochondrial enzyme glutaredoxin-5 and the hepatocyte membrane protein matriptase-2.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	117-121
20719010-7	2010	High hepcidin levels result in less iron being absorbed from the bowel than is necessary for erythropoiesis.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	5-13
12522007-0	2003	Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	18-24
12522007-0	2003	Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	25-29
12522007-1	2003	Mutations at natural resistance-associated macrophage protein 1 (Nramp1) impair phagocyte function and cause susceptibility to infections while mutations at Nramp2 (divalent metal transporter 1 [DMT1]) affect iron homeostasis and cause severe microcytic anemia.	Iron	209-213	solute carrier family 11 member 2	Homo sapiens	157-163
12522007-1	2003	Mutations at natural resistance-associated macrophage protein 1 (Nramp1) impair phagocyte function and cause susceptibility to infections while mutations at Nramp2 (divalent metal transporter 1 [DMT1]) affect iron homeostasis and cause severe microcytic anemia.	Iron	209-213	solute carrier family 11 member 2	Homo sapiens	165-200
12730455-2	2003	Several new potential mRNA targets for IRP were recently identified: divalent metal transporter-1 (DMT-1) and ferroportin, which are critical regulators of iron absorption in the gut and of iron cycling between various tissues of the body.	Iron	156-160	solute carrier family 11 member 2	Homo sapiens	69-97
12730455-2	2003	Several new potential mRNA targets for IRP were recently identified: divalent metal transporter-1 (DMT-1) and ferroportin, which are critical regulators of iron absorption in the gut and of iron cycling between various tissues of the body.	Iron	156-160	solute carrier family 11 member 2	Homo sapiens	99-104
20802456-0	2010	Effects of growth hormone and insulin-like growth factor-I on the iron-induced lipid peroxidation in the rat liver and porcine thyroid homogenates.	Iron	66-70	insulin-like growth factor 1	Rattus norvegicus	30-58
12730455-2	2003	Several new potential mRNA targets for IRP were recently identified: divalent metal transporter-1 (DMT-1) and ferroportin, which are critical regulators of iron absorption in the gut and of iron cycling between various tissues of the body.	Iron	190-194	solute carrier family 11 member 2	Homo sapiens	69-97
12730455-2	2003	Several new potential mRNA targets for IRP were recently identified: divalent metal transporter-1 (DMT-1) and ferroportin, which are critical regulators of iron absorption in the gut and of iron cycling between various tissues of the body.	Iron	190-194	solute carrier family 11 member 2	Homo sapiens	99-104
20802456-3	2010	The aim of the study was to evaluate the effect of GH and/or IGF-I on the iron-induced LPO in the rat liver and porcine thyroid homogenates.	Iron	74-78	insulin-like growth factor 1	Rattus norvegicus	61-66
20802456-9	2010	IGF-I, in all used concentrations, enhanced the iron-induced LPO.	Iron	48-52	insulin-like growth factor 1	Rattus norvegicus	0-5
19609632-0	2010	Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30.	Iron	114-118	olfactory receptor family 10 subfamily N member 1	Mus musculus	162-165
12803508-1	2003	BACKGROUND: Recent report demonstrates that inadequate iron mobilization and defective iron utilization may cause recombinant erythropoieitin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	55-59	erythropoietin	Rattus norvegicus	143-147
12803508-1	2003	BACKGROUND: Recent report demonstrates that inadequate iron mobilization and defective iron utilization may cause recombinant erythropoieitin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	87-91	erythropoietin	Rattus norvegicus	143-147
12803508-1	2003	BACKGROUND: Recent report demonstrates that inadequate iron mobilization and defective iron utilization may cause recombinant erythropoieitin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	87-91	erythropoietin	Rattus norvegicus	143-147
20041108-3	2009	In this study, we show that yersiniabactin increases bacterial growth when iron-saturated lactoferrin is the main iron source.	Iron	75-79	lactotransferrin	Mus musculus	90-101
12433676-2	2003	In animal models, hepcidin is induced by inflammation and iron loading, but its regulation in humans has not been studied.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	18-26
20041108-4	2009	This suggests that yersiniabactin provides bacteria with additional iron from saturated lactoferrin during infection.	Iron	68-72	lactotransferrin	Mus musculus	88-99
12433676-3	2003	We report that urinary excretion of hepcidin was greatly increased in patients with iron overload, infections, or inflammatory diseases.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	36-44
12433676-5	2003	In vitro iron loading of primary human hepatocytes, however, unexpectedly down-regulated hepcidin mRNA, suggesting that in vivo regulation of hepcidin expression by iron stores involves complex indirect effects.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	89-97
19740590-1	2009	OBJECTIVE: Hepcidin, a small 25 amino-acid antimicrobial peptide, has a significant role in the regulation of iron homeostasis.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	11-19
12433676-5	2003	In vitro iron loading of primary human hepatocytes, however, unexpectedly down-regulated hepcidin mRNA, suggesting that in vivo regulation of hepcidin expression by iron stores involves complex indirect effects.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	142-150
12433676-5	2003	In vitro iron loading of primary human hepatocytes, however, unexpectedly down-regulated hepcidin mRNA, suggesting that in vivo regulation of hepcidin expression by iron stores involves complex indirect effects.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	142-150
19821535-6	2009	Furthermore, in hepatocytes arrested by the iron chelator O-Trensox in early S-phase prior to DNA replication, Cdk1/cyclin complexes were active, while replication initiation components such as the minichromosome maintenance 7 (Mcm7) protein were loaded onto DNA.	Iron	44-48	cyclin dependent kinase 1	Homo sapiens	111-115
12668974-1	2003	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme catabolism, which leads to the generation of carbon monoxide (CO), biliverdin, and free iron.	Iron	148-152	heme oxygenase 1	Homo sapiens	0-16
12668974-1	2003	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme catabolism, which leads to the generation of carbon monoxide (CO), biliverdin, and free iron.	Iron	148-152	heme oxygenase 1	Homo sapiens	18-22
12637007-5	2003	The rate constant for cyanide binding to the heme iron of cytochrome c of cytochrome c-polyglutamate complex also decreases by approximately 42.5% with n&gt;or approximately equal 8.	Iron	50-54	cytochrome c, somatic	Equus caballus	58-70
12637007-5	2003	The rate constant for cyanide binding to the heme iron of cytochrome c of cytochrome c-polyglutamate complex also decreases by approximately 42.5% with n&gt;or approximately equal 8.	Iron	50-54	cytochrome c, somatic	Equus caballus	74-86
12637007-8	2003	The results indicate that the polyglutamate (n&gt;or approximately equal 8) is able to increase the stability of the methionine sulfur-heme iron bond of cytochrome c in spite of structural differences that weaken the overall stability of the cyt c at neutral and slightly alkaline pH.	Iron	140-144	cytochrome c, somatic	Equus caballus	153-165
12556365-4	2003	Catalytically active intracellular iron was markedly increased in hemin-treated IRPTCs and contributed to the induction of HO-1 and MCP-1 mRNA because an iron chelator blocked hemin-induced upregulation of both genes, whereas a cell-permeant form of iron directly induced these genes.	Iron	35-39	C-C motif chemokine ligand 2	Rattus norvegicus	132-137
12556365-4	2003	Catalytically active intracellular iron was markedly increased in hemin-treated IRPTCs and contributed to the induction of HO-1 and MCP-1 mRNA because an iron chelator blocked hemin-induced upregulation of both genes, whereas a cell-permeant form of iron directly induced these genes.	Iron	154-158	C-C motif chemokine ligand 2	Rattus norvegicus	132-137
12556365-4	2003	Catalytically active intracellular iron was markedly increased in hemin-treated IRPTCs and contributed to the induction of HO-1 and MCP-1 mRNA because an iron chelator blocked hemin-induced upregulation of both genes, whereas a cell-permeant form of iron directly induced these genes.	Iron	154-158	C-C motif chemokine ligand 2	Rattus norvegicus	132-137
12406888-2	2003	Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.	Iron	129-133	transferrin receptor 2	Homo sapiens	41-63
12406888-2	2003	Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.	Iron	129-133	transferrin receptor 2	Homo sapiens	65-69
12406888-3	2003	TfR2 is capable of Tf-mediated iron uptake and mutations in this gene result in a rare form of hereditary hemochromatosis unrelated to the hereditary hemochromatosis protein, HFE.	Iron	31-35	transferrin receptor 2	Homo sapiens	0-4
12531241-0	2003	Transferrin receptor 2: a new molecule in iron metabolism.	Iron	42-46	transferrin receptor 2	Homo sapiens	0-22
12531241-5	2003	Transferrin receptor 2, like transferrin receptor 1, binds transferrin in a pH-dependent manner (but with 25 times lower affinity) and delivers iron to cells.	Iron	144-148	transferrin receptor 2	Homo sapiens	0-22
12531241-8	2003	Mutations in the human transferrin receptor 2 gene cause iron overload disease, suggesting it has a role in iron homeostasis.	Iron	57-61	transferrin receptor 2	Homo sapiens	23-45
12674739-6	2003	The autosomal-dominant type 4 is located on chromosome 2q32 and affects the basolateral iron carrier ferroportin 1.	Iron	88-92	solute carrier family 40 member 1	Homo sapiens	101-114
12438312-10	2003	While mammalian ferritin H and L mRNAs are translationally regulated by iron, the amounts of C. elegans ftn-1 and ftn-2 mRNAs are increased by iron and decreased by iron chelation.	Iron	143-147	Ferritin	Caenorhabditis elegans	104-109
12438312-10	2003	While mammalian ferritin H and L mRNAs are translationally regulated by iron, the amounts of C. elegans ftn-1 and ftn-2 mRNAs are increased by iron and decreased by iron chelation.	Iron	143-147	Ferritin	Caenorhabditis elegans	104-109
12535786-0	2003	A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer"s disease.	Iron	78-82	microtubule associated protein tau	Homo sapiens	119-122
12411429-6	2003	Transformation of PDR1(R821H) into Deltaccc1 cells, which were previously shown to have increased sensitivity to high iron medium because of defective vacuolar iron storage (Li, L., Chen, O. S., Ward, D. M., and Kaplan, J.	Iron	118-122	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	18-22
12388109-0	2003	Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells.	Iron	28-32	solute carrier family 11 member 2	Homo sapiens	10-14
12388109-1	2003	DMT1 (divalent metal transporter 1) is a hydrogen-coupled divalent metal transporter with a substrate preference for iron, although the protein when expressed in frog oocytes transports a broad range of metals, including the toxic metals cadmium and lead.	Iron	117-121	solute carrier family 11 member 2	Homo sapiens	0-4
12388109-1	2003	DMT1 (divalent metal transporter 1) is a hydrogen-coupled divalent metal transporter with a substrate preference for iron, although the protein when expressed in frog oocytes transports a broad range of metals, including the toxic metals cadmium and lead.	Iron	117-121	solute carrier family 11 member 2	Homo sapiens	6-34
12388109-8	2003	These results show that DMT1 is important in iron and cadmium transport in Caco-2 cells but that lead enters these cells through an independent hydrogen-driven mechanism.	Iron	45-49	solute carrier family 11 member 2	Homo sapiens	24-28
12480684-0	2003	Enhancement by iron of interleukin 1 induced granulocyte macrophage colony stimulating factor (GM-CSF) production by human synovial fibroblasts.	Iron	15-19	colony stimulating factor 2	Homo sapiens	95-101
12667993-0	2003	Can defects in transferrin receptor 2 and hereditary hemochromatosis genes account for iron overload in HbH disease?	Iron	87-91	transferrin receptor 2	Homo sapiens	15-37
12667993-5	2003	Since only eight out of 45 iron-overloaded HbH patients carry a defect in the TFR2 or HFE gene in the heterozygote state and their iron loading status was comparable to the matched controls without such defects, it would appear that the accumulation of excess iron in HbH disease is more likely a result of increase dietary absorption secondary to ineffective erythropoiesis.	Iron	27-31	transferrin receptor 2	Homo sapiens	78-82
12480557-8	2003	Serum TRX tended to increase in accordance with hepatic iron accumulation and the histological severity in patients with NASH.	Iron	56-60	thioredoxin	Homo sapiens	6-9
12514265-8	2003	The decrease in pancreatic MT protein levels was paralleled by a dramatic decrease in the relative abundance of MT-I mRNA and a dramatic increase in the relative abundance of the zinc/iron regulated transporter-related zinc transporter-4 (ZIP4) mRNA in the embryonic visceral yolk sac.	Iron	184-188	solute carrier family 30 (zinc transporter), member 4	Mus musculus	219-237
12514265-8	2003	The decrease in pancreatic MT protein levels was paralleled by a dramatic decrease in the relative abundance of MT-I mRNA and a dramatic increase in the relative abundance of the zinc/iron regulated transporter-related zinc transporter-4 (ZIP4) mRNA in the embryonic visceral yolk sac.	Iron	184-188	solute carrier family 30 (zinc transporter), member 4	Mus musculus	239-243
12482971-0	2003	Iron status in mice carrying a targeted disruption of lactoferrin.	Iron	0-4	lactotransferrin	Mus musculus	54-65
12482971-2	2003	While several physiological functions have been proposed for lactoferrin, including the regulation of intestinal iron uptake, the exact function of this protein in vivo remains to be established.	Iron	113-117	lactotransferrin	Mus musculus	61-72
12445862-7	2002	In order to figure out whether or not doxorubicin can utilize iron from the transport protein transferrin for complex formation and prooxidative activities we studied the redox state of iron and its regulatory control by ceruloplasmin and ascorbate in the plasma of dogs suffering from malignant lymphoma by electron spin resonance spectroscopy.	Iron	186-190	inhibitor of carbonic anhydrase	Canis lupus familiaris	94-105
12445862-9	2002	Our results revealed that dogs with lymphoma exhibit lower levels of paramagnetic copper in ceruloplasmin (-22%) and iron in transferrin (-33%) than healthy animals.	Iron	117-121	inhibitor of carbonic anhydrase	Canis lupus familiaris	125-136
12445862-14	2002	Model experiments revealed that the effect is based on a doxorubicin-induced release of iron from transferrin which is enhanced by ascorbate and the subsequent formation of doxorubicin-iron complexes.	Iron	88-92	inhibitor of carbonic anhydrase	Canis lupus familiaris	98-109
12596608-4	2002	Since iron is needed for Hgb synthesis, iron depletion exacerbated anemia and reduces the response to recombinant erythropoietin (rEPO) therapy.	Iron	40-44	erythropoietin	Rattus norvegicus	130-134
12351628-1	2002	Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis.	Iron	60-64	ceruloplasmin	Homo sapiens	0-13
12457803-5	2002	Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter.	Iron	220-224	solute carrier family 40 member 1	Homo sapiens	293-305
12457803-5	2002	Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter.	Iron	220-224	solute carrier family 40 member 1	Homo sapiens	306-311
12457803-5	2002	Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter.	Iron	220-224	solute carrier family 40 member 1	Homo sapiens	312-316
12393650-3	2002	Mutations affecting the TFR-2 gene led to hemochromatosis type 3, a form of inherited iron overload.	Iron	86-90	transferrin receptor 2	Homo sapiens	24-29
12393650-9	2002	Exposure of human TFR-2(+) cells to TF-bound iron is followed by a significant up-regulation and relocalization of membrane TFR-2.	Iron	45-49	transferrin receptor 2	Homo sapiens	18-23
12393650-9	2002	Exposure of human TFR-2(+) cells to TF-bound iron is followed by a significant up-regulation and relocalization of membrane TFR-2.	Iron	45-49	transferrin receptor 2	Homo sapiens	124-129
12393650-10	2002	The tissue distribution pattern, the behavior following exposure to iron-loaded TF, and the features of the disease resulting from TFR-2 inactivation support the hypothesis that TFR-2 contributes to body iron sensing.	Iron	68-72	transferrin receptor 2	Homo sapiens	178-183
12393650-10	2002	The tissue distribution pattern, the behavior following exposure to iron-loaded TF, and the features of the disease resulting from TFR-2 inactivation support the hypothesis that TFR-2 contributes to body iron sensing.	Iron	204-208	transferrin receptor 2	Homo sapiens	178-183
12406098-0	2002	Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3).	Iron	51-55	solute carrier family 40 member 1	Homo sapiens	154-161
12547233-3	2002	We describe here the clinical and biological characteristics of autosomal dominant form of iron overload due to the N144H mutation of the SLC11A3 gene.	Iron	91-95	solute carrier family 40 member 1	Homo sapiens	138-145
12547233-10	2002	The disease in this family represents a non-classical form of iron overload caused by the N144H mutation in the SLC11A3 gene.	Iron	62-66	solute carrier family 40 member 1	Homo sapiens	112-119
12547237-10	2002	Using anti-TFR2 monoclonal antibodies we have confirmed expression of the protein in the liver but also in duodenal epithelial cells, and studied the protein functional behaviour in cell lines, in response to iron addition, iron deprivation and olo-transferrin exposure.	Iron	209-213	transferrin receptor 2	Homo sapiens	11-15
12547237-11	2002	Our results suggest a regulatory role of TFR2 in iron metabolism.	Iron	49-53	transferrin receptor 2	Homo sapiens	41-45
19821535-6	2009	Furthermore, in hepatocytes arrested by the iron chelator O-Trensox in early S-phase prior to DNA replication, Cdk1/cyclin complexes were active, while replication initiation components such as the minichromosome maintenance 7 (Mcm7) protein were loaded onto DNA.	Iron	44-48	proliferating cell nuclear antigen	Homo sapiens	116-122
12547237-14	2002	The pathogenetic role of TFR2 in hemochromatosis has been recently further demonstrated through the targeted expression of the Y250X human mutation in mice, which develop sings of iron overload identical to the human disease.	Iron	180-184	transferrin receptor 2	Homo sapiens	25-29
12547239-0	2002	Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.	Iron	14-18	solute carrier family 11 member 2	Homo sapiens	73-101
19821535-6	2009	Furthermore, in hepatocytes arrested by the iron chelator O-Trensox in early S-phase prior to DNA replication, Cdk1/cyclin complexes were active, while replication initiation components such as the minichromosome maintenance 7 (Mcm7) protein were loaded onto DNA.	Iron	44-48	minichromosome maintenance complex component 7	Homo sapiens	198-226
12547239-0	2002	Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.	Iron	14-18	solute carrier family 40 member 1	Homo sapiens	106-119
12547239-2	2002	Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	18-46
19821535-6	2009	Furthermore, in hepatocytes arrested by the iron chelator O-Trensox in early S-phase prior to DNA replication, Cdk1/cyclin complexes were active, while replication initiation components such as the minichromosome maintenance 7 (Mcm7) protein were loaded onto DNA.	Iron	44-48	minichromosome maintenance complex component 7	Homo sapiens	228-232
12547239-2	2002	Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	48-52
12547239-2	2002	Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium.	Iron	113-117	solute carrier family 40 member 1	Homo sapiens	58-71
19850683-3	2009	Hepcidin represents the main inhibitor of intestinal iron absorption, and its expression is increased in adipose tissue of obese patients.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	0-8
12547239-2	2002	Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium.	Iron	113-117	solute carrier family 40 member 1	Homo sapiens	73-77
12547239-3	2002	Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	9-13
12547239-3	2002	Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far.	Iron	36-40	solute carrier family 40 member 1	Homo sapiens	18-22
12547239-3	2002	Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far.	Iron	135-139	solute carrier family 11 member 2	Homo sapiens	9-13
12394829-2	2002	The cytoprotection may result from the elimination of heme and the function of HO-1 downstream mediators, that is, biliverdin, carbon monoxide, and free iron.	Iron	153-157	heme oxygenase 1	Homo sapiens	79-83
19850683-5	2009	OBJECTIVES: Aims of this work were 1) to assess the association between poor iron status and obesity, 2) to investigate whether iron homeostasis of obese children may be modulated by serum hepcidin variations, and 3) to assess the potential correlation between leptin and serum hepcidin variations.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	189-197
19850683-8	2009	A direct correlation between hepcidin and obesity degree (P = 0.0015), and inverse correlations between hepcidin and iron (P = 0.04), hepcidin and transferrin saturation (P = 0.005), and hepcidin and iron absorption (P = 0.003) were observed.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	104-112
12242109-5	2002	In addition, Fe depletion may also inhibit the newly identified p53-inducible form of this molecule called p53R2.	Iron	13-15	transformation related protein 53, pseudogene	Mus musculus	64-67
12242109-8	2002	Other regulatory molecules whose expression is affected by Fe depletion include p53 and hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	59-61	transformation related protein 53, pseudogene	Mus musculus	80-83
12242109-8	2002	Other regulatory molecules whose expression is affected by Fe depletion include p53 and hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	59-61	hypoxia inducible factor 1, alpha subunit	Mus musculus	88-119
19850683-8	2009	A direct correlation between hepcidin and obesity degree (P = 0.0015), and inverse correlations between hepcidin and iron (P = 0.04), hepcidin and transferrin saturation (P = 0.005), and hepcidin and iron absorption (P = 0.003) were observed.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	104-112
12242109-8	2002	Other regulatory molecules whose expression is affected by Fe depletion include p53 and hypoxia inducible factor-1alpha (HIF-1alpha).	Iron	59-61	hypoxia inducible factor 1, alpha subunit	Mus musculus	121-131
12242109-9	2002	The levels of p53 increase following Fe chelation via the ability of HIF-1alpha to bind and stabilize p53.	Iron	37-39	transformation related protein 53, pseudogene	Mus musculus	14-17
12242109-9	2002	The levels of p53 increase following Fe chelation via the ability of HIF-1alpha to bind and stabilize p53.	Iron	37-39	hypoxia inducible factor 1, alpha subunit	Mus musculus	69-79
19850683-8	2009	A direct correlation between hepcidin and obesity degree (P = 0.0015), and inverse correlations between hepcidin and iron (P = 0.04), hepcidin and transferrin saturation (P = 0.005), and hepcidin and iron absorption (P = 0.003) were observed.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	104-112
12242109-9	2002	The levels of p53 increase following Fe chelation via the ability of HIF-1alpha to bind and stabilize p53.	Iron	37-39	transformation related protein 53, pseudogene	Mus musculus	102-105
12242109-10	2002	The activity of HIF-1alpha is controlled by an Fe-dependent enzyme known as HIF-alpha prolyl hydroxylase (PH).	Iron	47-49	hypoxia inducible factor 1, alpha subunit	Mus musculus	16-26
12242109-11	2002	Chelation of Fe from this enzyme inhibits its activity, leading to stabilization of HIF-1alpha and the subsequent effects on downstream targets critical for angiogenesis and tumour growth.	Iron	13-15	hypoxia inducible factor 1, alpha subunit	Mus musculus	84-94
19850683-11	2009	CONCLUSIONS: We propose that in obese patients, increased hepcidin production, at least partly leptin mediated, represents the missing link between obesity and disrupted iron metabolism.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	58-66
12242109-12	2002	The levels of p53 may also increase after Fe chelation by phosphorylation of this protein at serine-15 and -37.	Iron	42-44	transformation related protein 53, pseudogene	Mus musculus	14-17
21415870-1	2009	BACKGROUND: Hepcidin, a key regulator of iron metabolism, is synthesized by the liver.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	12-20
12242109-14	2002	Iron chelation also markedly increases the mRNA levels of the p53-inducible cyclin-dependent kinase (cdk) inhibitor, p21(WAF1/CIP1).	Iron	0-4	transformation related protein 53, pseudogene	Mus musculus	62-65
12370282-0	2002	The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	46-54
21415870-2	2009	Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
21415870-2	2009	Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
12370282-1	2002	The present study was aimed at determining whether hepcidin, a recently identified peptide involved in iron metabolism, plays a role in conditions associated with both iron overload and iron deficiency.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	51-59
12370282-1	2002	The present study was aimed at determining whether hepcidin, a recently identified peptide involved in iron metabolism, plays a role in conditions associated with both iron overload and iron deficiency.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	51-59
21415870-3	2009	AIM: To study hepcidin expression in liver tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C (CHC) and normal human liver biopsies and to compare its level with serum and liver iron indices.	Iron	203-207	hepcidin antimicrobial peptide	Homo sapiens	14-22
12370282-4	2002	Anemia and hypoxia were associated with a dramatic decrease in liver hepcidin gene expression, which may account for the increase in iron release from reticuloendothelial cells and increase in iron absorption frequently observed in these situations.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	69-77
12370282-4	2002	Anemia and hypoxia were associated with a dramatic decrease in liver hepcidin gene expression, which may account for the increase in iron release from reticuloendothelial cells and increase in iron absorption frequently observed in these situations.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	69-77
21415870-11	2009	In contrast, hepcidin mRNA was negatively correlated with parameters of iron stores as (serum ferritin and HII) and grade of liver fibrosis in both patient groups.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	13-21
12370282-7	2002	These modifications of hepcidin gene expression further suggest a key role for hepcidin in iron homeostasis under various pathophysiological conditions, which may support the pharmaceutical use of hepcidin agonists and antagonists in various iron homeostasis disorders.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	23-31
12370282-7	2002	These modifications of hepcidin gene expression further suggest a key role for hepcidin in iron homeostasis under various pathophysiological conditions, which may support the pharmaceutical use of hepcidin agonists and antagonists in various iron homeostasis disorders.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	79-87
21415870-12	2009	CONCLUSION: The expression of hepcidin mRNA is decreased in liver tissues of CHC patients and more suppressed in the liver tissues of patients with HCC, suggesting that hepcidin expression appears to be appropriately responsive to iron status and disease progression in cirrhosis and hepatocarcinogenesis.	Iron	231-235	hepcidin antimicrobial peptide	Homo sapiens	30-38
12370282-7	2002	These modifications of hepcidin gene expression further suggest a key role for hepcidin in iron homeostasis under various pathophysiological conditions, which may support the pharmaceutical use of hepcidin agonists and antagonists in various iron homeostasis disorders.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	79-87
21415870-12	2009	CONCLUSION: The expression of hepcidin mRNA is decreased in liver tissues of CHC patients and more suppressed in the liver tissues of patients with HCC, suggesting that hepcidin expression appears to be appropriately responsive to iron status and disease progression in cirrhosis and hepatocarcinogenesis.	Iron	231-235	hepcidin antimicrobial peptide	Homo sapiens	169-177
26190951-2	2009	Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.	Iron	55-59	S-phase kinase associated protein 1	Homo sapiens	104-108
12200392-0	2002	Anemia and iron overload due to compound heterozygosity for novel ceruloplasmin mutations.	Iron	11-15	ceruloplasmin	Homo sapiens	66-79
12200392-1	2002	Aceruloplasminemia is a recessive disorder characterized by anemia, iron overload, and neurodegeneration, caused by the absence of ceruloplasmin (Cp), a multicopper oxidase important for iron export.	Iron	68-72	ceruloplasmin	Homo sapiens	1-14
12200392-1	2002	Aceruloplasminemia is a recessive disorder characterized by anemia, iron overload, and neurodegeneration, caused by the absence of ceruloplasmin (Cp), a multicopper oxidase important for iron export.	Iron	187-191	ceruloplasmin	Homo sapiens	1-14
12200392-1	2002	Aceruloplasminemia is a recessive disorder characterized by anemia, iron overload, and neurodegeneration, caused by the absence of ceruloplasmin (Cp), a multicopper oxidase important for iron export.	Iron	187-191	ceruloplasmin	Homo sapiens	146-148
19290800-4	2009	FTH generated MRI contrast through compensatory upregulation of transferrin receptor (Tfrc) that led to increased cellular iron stored in ferritin-bound form.	Iron	123-127	ferritin heavy chain 1	Homo sapiens	0-3
12220667-3	2002	Our data demonstrate that copper could compete with iron for uptake via DMT1 and that DMT1 protein and mRNA expression were decreased following exposure (24 h) to high copper.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	72-76
19715555-14	2009	Wild-type mouse RPE cells and human RPE cell lines, when loaded with iron by exposure to ferric ammonium citrate, showed increased expression and activity of xCT, reproducing the biochemical phenotype observed with Hfe-/- RPE cells.	Iron	69-73	solute carrier family 7 member 11	Homo sapiens	158-161
12362445-5	2002	On media containing the iron chelator dipyridyl, ferritin induced a growth inhibition effect that was further enhanced in the presence of lactoferrin in seven of the 13 tested strains.	Iron	24-28	lactotransferrin	Bos taurus	138-149
12362445-8	2002	Expression of lactoferrin-binding activity was independent of the level of iron in the medium and the iron saturation status of lactoferrin.	Iron	75-79	lactotransferrin	Bos taurus	14-25
12362445-8	2002	Expression of lactoferrin-binding activity was independent of the level of iron in the medium and the iron saturation status of lactoferrin.	Iron	102-106	lactotransferrin	Bos taurus	14-25
12362445-8	2002	Expression of lactoferrin-binding activity was independent of the level of iron in the medium and the iron saturation status of lactoferrin.	Iron	102-106	lactotransferrin	Bos taurus	128-139
19884259-5	2009	Using the level of intracellular iron to regulate the translation of specific mRNAs, we show that translation promotes not only removal of EJC constituents, including the eIF4AIII anchor, but also replacement of PABPN1 by PABPC1.	Iron	33-37	poly(A) binding protein nuclear 1	Homo sapiens	212-218
12427107-4	2002	Novel genes associated with iron uptake include Dcytb, a putative iron-regulated reductase and DMT1, a Fe(II) carrier in the brush border membrane.	Iron	28-32	doublesex and mab-3 related transcription factor 1	Homo sapiens	95-99
12163393-4	2002	HMGCR mRNA and Ras/Rho prenylation were also assessed after in vivo ischemic and Fe-mediated renal damage.	Iron	81-83	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	0-5
19884259-5	2009	Using the level of intracellular iron to regulate the translation of specific mRNAs, we show that translation promotes not only removal of EJC constituents, including the eIF4AIII anchor, but also replacement of PABPN1 by PABPC1.	Iron	33-37	poly(A) binding protein cytoplasmic 1	Homo sapiens	222-228
12163393-7	2002	Renal cortical HMGCR mRNA also fell in response to either in vivo ischemic or Fe-mediated oxidant damage.	Iron	78-80	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	15-20
19795866-1	2009	Absolute rate constants were determined for the abstraction of hydrogen atoms from (OC)(3)Fe(mu-SH)(2)Fe(CO)(3) (Fe(2)S(2)H(2)) and (OC)(3)Fe(mu-SCH(3))(mu-SH)Fe(CO)(3) (Fe(2)S(2)MeH) by benzyl radicals in benzene.	Iron	90-92	epoxide hydrolase 1	Homo sapiens	179-182
12196137-9	2002	Toxicity induced by alpha-synuclein, NAC and NAC(1-18) oligomers occurs via an apoptotic mechanism, possibly initiated by oxidative damage, since these peptides liberate hydroxyl radicals in the presence of iron.	Iron	207-211	synuclein alpha	Homo sapiens	20-35
12196137-9	2002	Toxicity induced by alpha-synuclein, NAC and NAC(1-18) oligomers occurs via an apoptotic mechanism, possibly initiated by oxidative damage, since these peptides liberate hydroxyl radicals in the presence of iron.	Iron	207-211	synuclein alpha	Homo sapiens	37-40
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	Iron	159-161	myosin light chain kinase	Homo sapiens	37-62
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	Iron	185-187	myosin light chain kinase	Homo sapiens	37-62
12196193-2	2002	Nramp1 modulates the cytoplasmic iron pool.	Iron	33-37	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
19795866-1	2009	Absolute rate constants were determined for the abstraction of hydrogen atoms from (OC)(3)Fe(mu-SH)(2)Fe(CO)(3) (Fe(2)S(2)H(2)) and (OC)(3)Fe(mu-SCH(3))(mu-SH)Fe(CO)(3) (Fe(2)S(2)MeH) by benzyl radicals in benzene.	Iron	102-104	epoxide hydrolase 1	Homo sapiens	179-182
12196193-8	2002	Results are consistent with a role for Nramp1 removing iron from the cytosol and antagonizing c-Myc function.	Iron	55-59	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	39-45
19795866-10	2009	Replacement of the Fe-Fe bond in Fe(2)S(2)MeH with bridging mu-S (Fe(2)S(3)MeH) or mu-CO (Fe(2)S(2)(CO)MeH) groups leads to (DFT) BDEs of 72.8 and 66.2 kcal/mol, the latter indicating dramatic effects of the choice of bridge structure on S-H bond strengths.	Iron	19-21	epoxide hydrolase 1	Homo sapiens	42-45
19795866-10	2009	Replacement of the Fe-Fe bond in Fe(2)S(2)MeH with bridging mu-S (Fe(2)S(3)MeH) or mu-CO (Fe(2)S(2)(CO)MeH) groups leads to (DFT) BDEs of 72.8 and 66.2 kcal/mol, the latter indicating dramatic effects of the choice of bridge structure on S-H bond strengths.	Iron	22-24	epoxide hydrolase 1	Homo sapiens	42-45
19849830-2	2009	Reduced carbon and nitrogen precursor compounds for the synthesis of HCN may be formed under off-axis hydrothermal conditions in oceanic lithosphere in the presence of native Fe and Ni and are adsorbed on authigenic layer silicates and zeolites.	Iron	175-177	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	69-72
12151537-0	2002	Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.	Iron	24-28	ceruloplasmin	Mus musculus	0-13
12151537-1	2002	Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form.	Iron	59-63	ceruloplasmin	Mus musculus	0-13
12151537-8	2002	These results indicate that ceruloplasmin plays an important role in maintaining iron homeostasis in the CNS and in protecting the CNS from iron-mediated free radical injury.	Iron	81-85	ceruloplasmin	Mus musculus	28-41
12151537-8	2002	These results indicate that ceruloplasmin plays an important role in maintaining iron homeostasis in the CNS and in protecting the CNS from iron-mediated free radical injury.	Iron	140-144	ceruloplasmin	Mus musculus	28-41
12151537-9	2002	Therefore, the antioxidant effects of ceruloplasmin could have important implications for various neurodegenerative diseases such as Parkinson"s disease and Alzheimer"s disease in which iron deposition is known to occur.	Iron	186-190	ceruloplasmin	Mus musculus	38-51
19761223-4	2009	The Fe that accumulated in aerobically grown cells was in the form of iron(III) phosphate nanoparticles similar to that which accumulates in yeast frataxin Yfh1p-deleted or yeast ferredoxin Yah1p-depleted cells.	Iron	4-6	adrenodoxin	Saccharomyces cerevisiae S288C	190-195
12127992-3	2002	DMT1-dependent lead transport was H(+)-dependent and was inhibited by iron.	Iron	70-74	solute carrier family 11 member 2	Homo sapiens	0-4
12127992-5	2002	These results show that DMT1 transports lead and iron with similar affinity in a yeast model suggesting that DMT1 is a transporter for lead.	Iron	49-53	solute carrier family 11 member 2	Homo sapiens	24-28
19393287-2	2009	Inappropriately low Hepcidin expression is implicated in the pathogenesis of hereditary hemochromatosis and iron-loading anemias, like the thalassemias.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	20-28
12127992-5	2002	These results show that DMT1 transports lead and iron with similar affinity in a yeast model suggesting that DMT1 is a transporter for lead.	Iron	49-53	solute carrier family 11 member 2	Homo sapiens	109-113
19555735-1	2009	Hepcidin, a peptide hormone produced by the liver, constitutes the master regulator of iron homeostasis in mammals allowing iron adaptation according to the body iron needs.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
11994302-0	2002	Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU.	Iron	72-76	iron-sulfur cluster assembly enzyme	Bos taurus	109-113
19555735-1	2009	Hepcidin, a peptide hormone produced by the liver, constitutes the master regulator of iron homeostasis in mammals allowing iron adaptation according to the body iron needs.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	0-8
19555735-1	2009	Hepcidin, a peptide hormone produced by the liver, constitutes the master regulator of iron homeostasis in mammals allowing iron adaptation according to the body iron needs.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	0-8
12076509-1	2002	Both dimethylarsinic acid (DMA(V)) and dimethylarsinous acid (DMA(III)) release iron from human liver ferritin (HLF) with or without the presence of ascorbic acid.	Iron	80-84	HLF transcription factor, PAR bZIP family member	Homo sapiens	112-115
12076509-2	2002	With ascorbic acid the rate of iron release from HLF by DMA(V) was intermediate (3.37 nM/min, P&lt;0.05) and by DMA(III) was much higher (16.3 nM/min, P&lt;0.001).	Iron	31-35	HLF transcription factor, PAR bZIP family member	Homo sapiens	49-52
19555735-3	2009	Different aspects of hepcidin regulation will be considered in this review, including regulation by the iron status and the BMP6/HJV/SMAD pathway.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	21-29
19306086-12	2009	Elevations in cell iron can possibly affect an increased expression of DMT1 and ferritin which function to diminish oxidative stress.	Iron	19-23	solute carrier family 11 member 2	Homo sapiens	71-75
12111823-4	2002	We investigated the expression of the main proteins of iron metabolism in the spinal cord (SC) of totally gastrectomized Cbl-D rats 2 months after surgery (i.e., when the Cbl-D status has become severe).	Iron	55-59	Cbl proto-oncogene	Rattus norvegicus	121-124
12111823-4	2002	We investigated the expression of the main proteins of iron metabolism in the spinal cord (SC) of totally gastrectomized Cbl-D rats 2 months after surgery (i.e., when the Cbl-D status has become severe).	Iron	55-59	metabolism of cobalamin associated D	Rattus norvegicus	121-126
19330300-0	2009	Age-related changes in iron homeostasis in mouse ferroxidase mutants.	Iron	23-27	ceruloplasmin	Mus musculus	49-60
12082007-0	2002	Heme oxygenase-1-mediated protection: potential role of nonheme iron-nitric oxide complexes.	Iron	64-68	heme oxygenase 1	Homo sapiens	0-16
19484405-7	2009	At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	80-88
12044861-2	2002	Variants of human ceruloplasmin, in which residues proposed to be involved in electron transfer and/or iron-binding had been altered by site-directed mutagenesis, were expressed in HEK293 cells.	Iron	103-107	ceruloplasmin	Homo sapiens	18-31
19484405-7	2009	At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	80-88
19874266-5	2009	Induction of the astroglial ho-1 gene may constitute a "common pathway" leading to pathological brain iron deposition, intracellular oxidative damage and bioenergetic failure in AD and other human CNS disorders.	Iron	102-106	heme oxygenase 1	Homo sapiens	28-32
12034567-5	2002	Iron loading caused nuclear factor (NF)-kappaB activation, decreased levels of total IkappaBalpha, but relatively increased levels of both IkappaBalpha-phosphoserine 32/36 and IkappaBalpha-phosphotyrosine.	Iron	0-4	NFKB inhibitor alpha	Rattus norvegicus	85-97
12034567-5	2002	Iron loading caused nuclear factor (NF)-kappaB activation, decreased levels of total IkappaBalpha, but relatively increased levels of both IkappaBalpha-phosphoserine 32/36 and IkappaBalpha-phosphotyrosine.	Iron	0-4	NFKB inhibitor alpha	Rattus norvegicus	139-151
19563467-1	2009	BACKGROUND: Hepcidin, a liver-derived peptide induced by iron overload and inflammation, is a major regulator of iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	12-20
12034567-5	2002	Iron loading caused nuclear factor (NF)-kappaB activation, decreased levels of total IkappaBalpha, but relatively increased levels of both IkappaBalpha-phosphoserine 32/36 and IkappaBalpha-phosphotyrosine.	Iron	0-4	NFKB inhibitor alpha	Rattus norvegicus	139-151
19563467-1	2009	BACKGROUND: Hepcidin, a liver-derived peptide induced by iron overload and inflammation, is a major regulator of iron homeostasis.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	12-20
11850416-0	2002	Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein.	Iron	35-39	synuclein alpha	Homo sapiens	63-78
11850416-4	2002	To understand how changes in iron and magnesium might affect the pathophysiology of Parkinson"s disease, we investigated binding of iron to alpha-synuclein, which accumulates in Lewy bodies.	Iron	132-136	synuclein alpha	Homo sapiens	140-155
19563467-4	2009	Furthermore, we determined the impact of dialysis and iron and/or erythropoietin (rhEpo) supplementation therapy on hepcidin serum concentrations.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	116-124
11850416-5	2002	Using fluorescence of the four tyrosines in alpha-synuclein as indicators of metal-related conformational changes in alpha-synuclein, we show that iron and magnesium both interact with alpha-synuclein.	Iron	147-151	synuclein alpha	Homo sapiens	44-59
11850416-5	2002	Using fluorescence of the four tyrosines in alpha-synuclein as indicators of metal-related conformational changes in alpha-synuclein, we show that iron and magnesium both interact with alpha-synuclein.	Iron	147-151	synuclein alpha	Homo sapiens	117-132
19563467-10	2009	CONCLUSIONS: Hepcidin levels in stable haemodialysis patients appear to reflect systemic iron load, but not inflammation.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	13-21
11850416-5	2002	Using fluorescence of the four tyrosines in alpha-synuclein as indicators of metal-related conformational changes in alpha-synuclein, we show that iron and magnesium both interact with alpha-synuclein.	Iron	147-151	synuclein alpha	Homo sapiens	117-132
11850416-7	2002	Iron lowers both fluorescence peaks, while magnesium increases the fluorescence peak only at 375 nm, which suggests that magnesium affects the conformation of alpha-synuclein differently than iron.	Iron	0-4	synuclein alpha	Homo sapiens	159-174
11850416-9	2002	In each of these studies, iron increases alpha-synuclein aggregation, while magnesium at concentrations &gt;0.75 mm inhibits the aggregation of alpha-synuclein induced either spontaneously or by incubation with iron.	Iron	26-30	synuclein alpha	Homo sapiens	41-56
11850416-9	2002	In each of these studies, iron increases alpha-synuclein aggregation, while magnesium at concentrations &gt;0.75 mm inhibits the aggregation of alpha-synuclein induced either spontaneously or by incubation with iron.	Iron	211-215	synuclein alpha	Homo sapiens	144-159
11850416-10	2002	These data suggest that the conformation of alpha-synuclein can be modulated by metals, with iron promoting aggregation and magnesium inhibiting aggregation.	Iron	93-97	synuclein alpha	Homo sapiens	44-59
19851447-1	2009	We study apo and holo forms of the bacterial ferric binding protein (FBP) which exhibits the so-called ferric transport dilemma: it uptakes iron from the host with remarkable affinity, yet releases it with ease in the cytoplasm for subsequent use.	Iron	140-144	folate receptor beta	Homo sapiens	45-67
11964143-0	2002	Ferritin expression modulates cell cycle dynamics and cell responsiveness to H-ras-induced growth via expansion of the labile iron pool.	Iron	126-130	HRas proto-oncogene, GTPase	Homo sapiens	77-82
19851447-1	2009	We study apo and holo forms of the bacterial ferric binding protein (FBP) which exhibits the so-called ferric transport dilemma: it uptakes iron from the host with remarkable affinity, yet releases it with ease in the cytoplasm for subsequent use.	Iron	140-144	folate receptor beta	Homo sapiens	69-72
19851447-9	2009	Thus, iron uptake by FBP is a favored process in the fluctuating environment of the protein, whereas iron release is controlled by mechanisms including chelation and allostery.	Iron	6-10	folate receptor beta	Homo sapiens	21-24
19851447-9	2009	Thus, iron uptake by FBP is a favored process in the fluctuating environment of the protein, whereas iron release is controlled by mechanisms including chelation and allostery.	Iron	68-72	folate receptor beta	Homo sapiens	21-24
12086049-5	2002	The addition of iron to the medium containing a combination of penicillin and lactoferrin had no effect on growth inhibition.	Iron	16-20	lactotransferrin	Bos taurus	78-89
19736979-2	2009	This model favors the reduction of the outermost iron with His87 and Cys83 ligands, which is supported by orientation-selected hyperfine sublevel correlation (HYSCORE) characterization of the uniformly (15)N-labeled mitoNEET showing one strongly coupled nitrogen from the His87 N(delta) ligand with hyperfine coupling (15)a = 8 MHz.	Iron	49-53	CDGSH iron sulfur domain 1	Homo sapiens	216-224
11933019-2	2002	However, it was not until recently with the identification and characterization of several new genes related to iron homeostasis, such as the hemochromatosis protein HFE and the iron transporter DMT1, that our knowledge has been advanced dramatically.	Iron	112-116	doublesex and mab-3 related transcription factor 1	Homo sapiens	195-199
11933019-4	2002	Iron is released from transferrin as the result of the acidic pH in endosome and then is transported to the cytosol by DMT1.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	119-123
19777608-0	2009	Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells.	Iron	0-4	heme oxygenase 1	Homo sapiens	15-20
11937551-1	2002	Lactoferrin (Lf) is an iron-binding protein of external secretions and neutrophil secondary granules with antimicrobial and immunomodulatory activities.	Iron	23-27	lactotransferrin	Mus musculus	0-11
11937551-1	2002	Lactoferrin (Lf) is an iron-binding protein of external secretions and neutrophil secondary granules with antimicrobial and immunomodulatory activities.	Iron	23-27	lactotransferrin	Mus musculus	13-15
19777608-4	2009	RESULTS: Iron, in the form of ferric nitrilotriacetate, increased oxidative stress and up-regulated HMOX1 gene expression.	Iron	9-13	heme oxygenase 1	Homo sapiens	100-105
19777608-9	2009	CONCLUSION: Excess iron up-regulates HMOX1 and down-regulates HCV gene expression in hepatoma cells.	Iron	19-23	heme oxygenase 1	Homo sapiens	37-42
19735144-5	2009	Raman spectra indicated that the interaction of Mb molecules with NiAl-HTlc nanoparticles modified the porphyrin core, changing the spin state of the heme iron from high spin (HS) to low spin (LS).	Iron	155-159	myoglobin	Homo sapiens	48-50
19553669-1	2009	Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds, which has been shown to act as the principal regulator of iron homeostasis in vertebrates.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	0-8
19610021-5	2009	Recently, hepcidin has been shown to regulate iron homeostasis by interaction with ferroportin, an iron cellular exporter highly expressed in absorptive enterocytes, macrophages, hepatocytes, and placental cells [4].	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	10-18
19610021-5	2009	Recently, hepcidin has been shown to regulate iron homeostasis by interaction with ferroportin, an iron cellular exporter highly expressed in absorptive enterocytes, macrophages, hepatocytes, and placental cells [4].	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	10-18
19500110-2	2009	The natural resistance-associated macrophage protein 1, Slc11a1, is a phagolysosomal transporter for protons and divalent ions including iron that confers host protection against diverse intracellular pathogens including Salmonella.	Iron	137-141	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	56-63
19500110-4	2009	We report that macrophages lacking functional Slc11a1 displayed an increased expression of transferrin receptor 1, resulting in enhanced acquisition of transferrin-bound iron.	Iron	170-174	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	46-53
19500110-5	2009	In contrast, cellular iron release mediated via ferroportin 1 was significantly lower in Salmonella-infected Slc11a1-negative macrophages in comparison with phagocytes bearing Slc11a1.	Iron	22-26	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	109-116
19500110-7	2009	Moreover, Slc11a1-negative phagocytes exhibited higher cellular iron content, resulting in increased iron acquisition by intracellular Salmonella.	Iron	64-68	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	10-17
19500110-7	2009	Moreover, Slc11a1-negative phagocytes exhibited higher cellular iron content, resulting in increased iron acquisition by intracellular Salmonella.	Iron	101-105	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	10-17
19524686-2	2009	This study compares the cellular response of Fe transporters in Caco-2, HT29-MTX, and Caco-2/HT29-MTX co-culture models for Fe bioavailability.	Iron	45-47	metaxin 1	Homo sapiens	77-80
19524686-2	2009	This study compares the cellular response of Fe transporters in Caco-2, HT29-MTX, and Caco-2/HT29-MTX co-culture models for Fe bioavailability.	Iron	45-47	metaxin 1	Homo sapiens	98-101
19524686-6	2009	In Caco-2/HT29-MTX co-cultures, the mucin layer lowered the pool of free Fe to diffuse towards the cell brush border membrane of enterocytes, which was accompanied of an upregulation of DMT1 mRNA expression.	Iron	73-75	metaxin 1	Homo sapiens	15-18
20169869-1	2009	Lactoferrin, an iron-chelating protein present in the granules of polymorphonuclear leukocytes and in the milk whey is having powerful osteogenic activity, as demonstrated by experiments performed in vitro on osteoblast cell cultures and in vivo on mice.	Iron	16-20	lactotransferrin	Mus musculus	0-11
19580807-3	2009	We report 5-LOX expression in the central nervous system (CNS) and analyze the pain efficacy of a new class of non redox, non iron chelating 5-LOX inhibitor.	Iron	126-130	arachidonate 5-lipoxygenase	Rattus norvegicus	141-146
19592589-4	2009	Here, we show that mutation of a region of FpvA that interacts with TonB1 (the TonB box) prevents this signaling process, as well as inhibiting bacterial growth in the presence of the iron-chelating compound ethylenediamine-di(o-hydroxy-phenylacetic acid).	Iron	184-188	transporter TonB	Pseudomonas aeruginosa PAO1	68-73
20136044-2	2009	The potential to accumulate metals like iron, nickel, manganese and copper by Trapa bipinosa was assessed by subjecting them to different effluent concentrations of pulp and paper industry under laboratory conditions.	Iron	40-44	signal sequence receptor subunit 1	Homo sapiens	78-83
19882863-8	2009	The nitro compounds showing the properties of NO donors (RNO2) were determined as the substances that acquire the properties of DNIC in the presence of ferrous iron and thiols.	Iron	152-164	NLR family pyrin domain containing 12	Homo sapiens	57-61
19698085-3	2009	Each RGM also displays a discrete tissue-specific pattern of gene and protein expression, and each is proposed to have unique biological functions, ranging from axonal guidance during development (RGMa) to regulation of systemic iron metabolism (RGMc).	Iron	229-233	hemojuvelin BMP co-receptor	Homo sapiens	246-250
19698085-4	2009	All three RGM proteins appear capable of binding selected BMPs (bone morphogenetic proteins), and interactions with BMPs mediate at least some of the biological effects of RGMc on iron metabolism, but to date no role for BMPs has been defined in the actions of RGMa or RGMb.	Iron	180-184	hemojuvelin BMP co-receptor	Homo sapiens	172-176
27683336-0	2009	Hepcidin and Its Role in Iron Homeostasis.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
27683336-1	2009	Hepcidin, a small peptide secreted mainly by the liver, plays a central role in iron status regulation.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
27683336-2	2009	The experiments on hepcidin seemed very promising and gave new life to understanding iron metabolism.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	19-27
27683336-3	2009	Many authors suggest that hepcidin measurement can be used as a clinical tool for the diagnosis and management of a wide range of iron-related disorders.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	26-34
19656379-1	2009	BACKGROUND: Hepcidin has an important role in iron metabolism.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	12-20
19536851-3	2009	Hepcidin synthesis is upregulated during chronic inflammation, reducing intestinal iron absorption and promoting retention of iron in the reticuloendothelial cells.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	0-8
19536851-3	2009	Hepcidin synthesis is upregulated during chronic inflammation, reducing intestinal iron absorption and promoting retention of iron in the reticuloendothelial cells.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	0-8
19451301-1	2009	Lactoferrin (LF) is an iron-binding antimicrobial protein present in saliva and gingival crevicular fluids, and it is possibly associated with host defense against oral pathogens, including periodontopathic bacteria.	Iron	23-27	HLF transcription factor, PAR bZIP family member	Homo sapiens	13-15
19451301-5	2009	These results demonstrate the antibiofilm activity of LF with lower iron dependency against P. gingivalis and P. intermedia and the potential usefulness of LF for the prevention and treatment of periodontal diseases and as adjunct therapy for periodontal diseases.	Iron	68-72	HLF transcription factor, PAR bZIP family member	Homo sapiens	54-56
19589485-2	2009	Because hepcidin plays a central role in the regulation of iron homeostasis, we analyzed the association between pretransplant serum hepcidin-25 levels and early infectious complications after allogeneic HSCT.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	8-16
12006174-10	2002	Among the products of HO-1, biliverdin and bilirubin showed no effect, whereas iron ions inhibited VEGF synthesis.	Iron	79-83	vascular endothelial growth factor A	Rattus norvegicus	99-103
19656486-1	2009	Two studies (Shah et al., 2009; Mastrogiannaki et al., 2009) show that the hypoxia inducible factor HIF-2alpha is a major player in regulating iron absorption by directly controlling the transcription of iron transporters in the intestine in response to changes in mucosal iron or oxygen levels.	Iron	143-147	endothelial PAS domain protein 1	Homo sapiens	100-110
12006174-13	2002	As CO and iron, respectively the inducer and the inhibitor of VEGF synthesis, are concomitantly produced during the degradation of heme, these data indicate that HO by-products may differentially modulate VEGF production.	Iron	10-14	vascular endothelial growth factor A	Rattus norvegicus	62-66
19656486-1	2009	Two studies (Shah et al., 2009; Mastrogiannaki et al., 2009) show that the hypoxia inducible factor HIF-2alpha is a major player in regulating iron absorption by directly controlling the transcription of iron transporters in the intestine in response to changes in mucosal iron or oxygen levels.	Iron	204-208	endothelial PAS domain protein 1	Homo sapiens	100-110
11915039-5	2002	ALA- and iron-treated Cyp1a2(+/+) mice are known to accumulate hepatic uroporphyrin; this accumulation was increased 7-fold by pretreatment with the low dose of PCB126.	Iron	9-13	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	22-28
19656486-2	2009	The HIF-2alpha mechanism has major effects on iron metabolism which can override the well-known hepcidin-ferroportin regulatory axis.	Iron	46-50	endothelial PAS domain protein 1	Homo sapiens	4-14
11915039-6	2002	ALA- and iron-treated Cyp1a2(+/-) heterozygote mice accumulated no uroporphyrin in 4 weeks, but by 8 weeks accumulated significant amounts of uroporphyrin.	Iron	9-13	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	22-28
11915039-7	2002	As previously reported, the ALA- and iron-treated Cyp1a2(-/-) knockout mouse has no CYP1A2 and exhibits no detectable uroporphyrin accumulation.	Iron	37-41	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	50-56
19656486-2	2009	The HIF-2alpha mechanism has major effects on iron metabolism which can override the well-known hepcidin-ferroportin regulatory axis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	96-104
11915039-8	2002	Iron dose-response curves in ALA- and PCB126-treated Cyp1a2(+/+) mice showed that hepatic iron levels greater than 850 microg/g liver were required to produce significant uroporphyrin accumulation in the liver.	Iron	0-4	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	53-59
11915039-11	2002	We conclude that small changes in hepatic CYP1A2 levels can dramatically affect uroporphyria in C57BL/6 mice, providing the animals have been sufficiently loaded with iron; these data might be clinically relevant to acquired (sporadic) porphyria cutanea tarda, because humans show greater than 60-fold genetic differences in hepatic basal CYP1A2.	Iron	167-171	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	42-48
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Iron	92-96	presenilin 1	Mus musculus	147-159
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Iron	92-96	presenilin 1	Mus musculus	161-165
19656030-13	2009	Exogenous CP treatment of healthy PMNs resulted in significant increases in O(2)(-) generation and iron ion conversion similar to LAgP PMNs.	Iron	99-103	ceruloplasmin	Homo sapiens	10-12
19453295-1	2009	Mrs3p and Mrs4p (Mrs3/4p) are yeast mitochondrial iron carrier proteins that play important roles in ISC (iron-sulphur cluster) and haem biosynthesis.	Iron	50-54	Fe(2+) transporter	Saccharomyces cerevisiae S288C	10-15
19453295-1	2009	Mrs3p and Mrs4p (Mrs3/4p) are yeast mitochondrial iron carrier proteins that play important roles in ISC (iron-sulphur cluster) and haem biosynthesis.	Iron	106-110	Fe(2+) transporter	Saccharomyces cerevisiae S288C	10-15
19453295-11	2009	RNA interference of the putative Drosophila orthologue of human ABCB7, a mitochondrial transporter involved in cytoplasmic ISC protein maturation, restored Fer1HCH transcript levels of iron-treated mbn-dmfrn cells to those of control cells grown in normal medium.	Iron	185-189	ATP binding cassette subfamily B member 7	Homo sapiens	64-69
19383972-1	2009	The interaction between the hormone hepcidin and the iron exporter ferroportin (Fpn) regulates plasma iron concentrations.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	36-44
19383972-2	2009	Hepcidin binds to Fpn and induces its internalization and degradation, resulting in decreased iron efflux from cells into plasma.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	0-8
19401454-3	2009	The present study demonstrated that LDL oxidized by copper, iron, or 3-morpholinosydnonimine increased the expression of NADPH oxidase (NOX) 2, PAI-1, and heat shock factor-1 (HSF1) in human umbilical vein EC or coronary artery EC compared with LDL or vehicle.	Iron	60-64	serpin family E member 1	Homo sapiens	144-149
19406916-1	2009	BACKGROUND: Hepcidin is thought to be the central regulator of iron metabolism.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	12-20
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	23-27	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	31-40
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	31-40
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	myoglobin	Homo sapiens	175-184
19798981-8	2009	For the first time, the authors confirmed that the direct interaction has occurred between heme-iron of myoglobin and additional metal ions, and saw about how the metal ions intension affects the direct interaction.	Iron	96-100	myoglobin	Homo sapiens	104-113
19452451-3	2009	However, iron egress from the basolateral side of enterocytes converges on a single export pathway requiring the iron transporter, ferroportin1, and hephaestin, a ferroxidase.	Iron	9-13	solute carrier family 40 member 1	Homo sapiens	131-143
19457088-8	2009	In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial sequestration of non-transferrin iron and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure amply documented in Alzheimer disease, Parkinson disease and other aging-related neurodegenerative disorders.	Iron	100-104	heme oxygenase 1	Homo sapiens	25-29
19457088-8	2009	In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial sequestration of non-transferrin iron and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure amply documented in Alzheimer disease, Parkinson disease and other aging-related neurodegenerative disorders.	Iron	171-175	heme oxygenase 1	Homo sapiens	25-29
19475336-3	2009	Therefore, it is tempting that the iron-releasing key enzyme in heme catabolism, heme oxygenase-1 (HO-1), may represent a candidate for a genetic susceptibility to PD.	Iron	35-39	heme oxygenase 1	Homo sapiens	81-97
19475336-3	2009	Therefore, it is tempting that the iron-releasing key enzyme in heme catabolism, heme oxygenase-1 (HO-1), may represent a candidate for a genetic susceptibility to PD.	Iron	35-39	heme oxygenase 1	Homo sapiens	99-103
19264680-5	2009	The increased iron use and reduced hepcidin levels suggested increased iron mobilization, but the treatment was associated with increased muscle iron and L ferritin levels.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	35-43
19264680-5	2009	The increased iron use and reduced hepcidin levels suggested increased iron mobilization, but the treatment was associated with increased muscle iron and L ferritin levels.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	35-43
19508729-14	2009	The metabolites biliverdin and iron seem to be involved in HO-1-mediated resistance to anticancer treatment.	Iron	31-35	heme oxygenase 1	Homo sapiens	59-63
19406957-0	2009	Hepcidin--a potential novel biomarker for iron status in chronic kidney disease.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
19406957-1	2009	BACKGROUND AND OBJECTIVES: Hepcidin is a key regulator of iron homeostasis, but its study in the setting of chronic kidney disease (CKD) has been hampered by the lack of validated serum assays.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	27-35
19406957-4	2009	Multivariate regression analysis was used to assess the relationship between hepcidin and indicators of anemia, iron status, inflammation, and renal function.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	77-85
19406957-7	2009	In PCKD5D (R(2) = 0.52), percent iron saturation and ferritin were predictors of hepcidin.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	81-89
19406957-9	2009	CONCLUSIONS: These findings suggest that increased hepcidin across the spectrum of CKD may contribute to abnormal iron regulation and erythropoiesis and may be a novel biomarker of iron status and erythropoietin resistance.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	51-59
19406957-9	2009	CONCLUSIONS: These findings suggest that increased hepcidin across the spectrum of CKD may contribute to abnormal iron regulation and erythropoiesis and may be a novel biomarker of iron status and erythropoietin resistance.	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	51-59
19307463-7	2009	On the other hand, expression of hepcidin, TfR2, ferroportin 1 and DMT1 were significantly up-regulated in iron-loaded non-cirrhotic non-tumorous liver tissues as compared with normal liver controls.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	33-41
19307463-7	2009	On the other hand, expression of hepcidin, TfR2, ferroportin 1 and DMT1 were significantly up-regulated in iron-loaded non-cirrhotic non-tumorous liver tissues as compared with normal liver controls.	Iron	107-111	transferrin receptor 2	Homo sapiens	43-47
19307463-7	2009	On the other hand, expression of hepcidin, TfR2, ferroportin 1 and DMT1 were significantly up-regulated in iron-loaded non-cirrhotic non-tumorous liver tissues as compared with normal liver controls.	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	49-62
19307463-8	2009	Hence, the reduction of hepcidin expression within the iron-depleted tumorous lesions likely reflects the physiological consequence of the obligate demand for iron in the rapidly growing neoplastic cells, whereas the up-regulation of hepcidin expression in the iron-loaded adjacent non-tumorous liver tissues is likely a physiological response.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	24-32
19307463-8	2009	Hence, the reduction of hepcidin expression within the iron-depleted tumorous lesions likely reflects the physiological consequence of the obligate demand for iron in the rapidly growing neoplastic cells, whereas the up-regulation of hepcidin expression in the iron-loaded adjacent non-tumorous liver tissues is likely a physiological response.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	24-32
19307463-8	2009	Hence, the reduction of hepcidin expression within the iron-depleted tumorous lesions likely reflects the physiological consequence of the obligate demand for iron in the rapidly growing neoplastic cells, whereas the up-regulation of hepcidin expression in the iron-loaded adjacent non-tumorous liver tissues is likely a physiological response.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	24-32
19449457-2	2009	Here we show altered iron homeostasis in mouse models of both GM1 and GM2 gangliosidoses, which are characterized by progressive depletion of iron in brain tissue.	Iron	21-25	cytochrome b5 domain containing 2	Mus musculus	70-73
11895945-7	2002	pCP1 was highly unstable in iron-deficient medium, and no enhanced mouse virulence conferred by MRS40 carrying pCP1 could be detected.	Iron	28-32	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	0-4
19449457-2	2009	Here we show altered iron homeostasis in mouse models of both GM1 and GM2 gangliosidoses, which are characterized by progressive depletion of iron in brain tissue.	Iron	142-146	cytochrome b5 domain containing 2	Mus musculus	70-73
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	0-8
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	154-166
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	99-103
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	104-108
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	109-115
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	148-153
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	154-166
11925462-4	2002	The aim of this study was to investigate the effects of iron treatment on DMT1 and IREG1 mRNA expression in Caco-2 cells, a human intestinal cell line.	Iron	56-60	solute carrier family 11 member 2	Homo sapiens	74-78
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	84-92
11925462-4	2002	The aim of this study was to investigate the effects of iron treatment on DMT1 and IREG1 mRNA expression in Caco-2 cells, a human intestinal cell line.	Iron	56-60	solute carrier family 40 member 1	Homo sapiens	83-88
11925462-5	2002	Exposure of the cells to iron (200 micromol/L ferric nitrilotriacetic acid for 72 h) significantly decreased transferrin receptor mRNA (80%), DMT1 mRNA (57%) and IREG1 mRNA (52%).	Iron	25-29	solute carrier family 11 member 2	Homo sapiens	142-146
11925462-5	2002	Exposure of the cells to iron (200 micromol/L ferric nitrilotriacetic acid for 72 h) significantly decreased transferrin receptor mRNA (80%), DMT1 mRNA (57%) and IREG1 mRNA (52%).	Iron	25-29	solute carrier family 40 member 1	Homo sapiens	162-167
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	84-92
11958522-5	2002	Iron deposition in hippocampal CA1 area was coupled to delayed pyramidal cell death.	Iron	0-4	carbonic anhydrase 1	Rattus norvegicus	31-34
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
11958522-6	2002	Perl"s reaction with DAB intensification revealed of the 1 week iron deposits in the CA1 area, which gradually increased and formed clusters by 8 weeks.	Iron	64-68	carbonic anhydrase 1	Rattus norvegicus	85-88
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	84-92
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
19478464-1	2009	Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	84-92
19293425-2	2009	Hepcidin controls cellular iron efflux on binding to the iron export protein ferroportin.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
12202156-1	2002	Nramp1 (natural resistance-associated macrophage protein 1) is a phagosomal iron transport molecule.	Iron	76-80	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
12202156-6	2002	These results suggest that generation of oxidants by Nramp1 iron transport activates MAP kinase signaling cascades that result in stabilization of Nramp1 mRNA.	Iron	60-64	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	53-59
12202156-6	2002	These results suggest that generation of oxidants by Nramp1 iron transport activates MAP kinase signaling cascades that result in stabilization of Nramp1 mRNA.	Iron	60-64	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	147-153
19293425-2	2009	Hepcidin controls cellular iron efflux on binding to the iron export protein ferroportin.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
19293425-7	2009	Individuals with ACD/IDA have significantly lower hepcidin levels than ACD subjects, and ACD/IDA persons, in contrast to ACD subjects, were able to absorb dietary iron from the gut and to mobilize iron from macrophages.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	50-58
19293425-8	2009	Circulating hepcidin levels affect iron traffic in ACD and ACD/IDA and are more responsive to the erythropoietic demands for iron than to inflammation.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	12-20
19293425-8	2009	Circulating hepcidin levels affect iron traffic in ACD and ACD/IDA and are more responsive to the erythropoietic demands for iron than to inflammation.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	12-20
19251588-9	2009	In contrast, heme oxygenase-1 was strongly suppressed by DFO, both in the absence and presence of LPS or iron.	Iron	105-109	heme oxygenase 1	Homo sapiens	13-29
11815303-3	2002	Our studies have demonstrated that the level of the iron transport protein, p97, is increased in the serum of AD patients but not in various control groups.	Iron	52-56	melanotransferrin	Homo sapiens	76-79
11815303-6	2002	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	62-65
11815303-6	2002	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	148-151
19416716-1	2009	Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content.	Iron	53-57	solute carrier family 40 member 1	Homo sapiens	13-17
11836175-0	2002	Absence of hepcidin gene mutations in 10 Italian patients with primary iron overload.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	11-19
19416716-1	2009	Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	13-17
11809412-0	2002	Ferroportin1: a new iron export molecule?	Iron	20-24	solute carrier family 40 member 1	Homo sapiens	0-12
19416716-1	2009	Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	13-17
11809412-1	2002	Ferroportin1 is a newly discovered molecule that may play a role in iron export.	Iron	68-72	solute carrier family 40 member 1	Homo sapiens	0-12
19416716-1	2009	Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	13-17
11809412-5	2002	In addition, the ferroportin1 mRNA transcript contains an iron response element in its 5" untranslated region.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	17-29
19416716-1	2009	Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	13-17
11935295-1	2002	The non-covalent association of beta 2-microglobulin with MHC class I molecules and MHC class I-type molecules such as FcRn or the hemochromatosis protein (HFE) is of major importance for their function, i.e., antigen presentation, IgG transport, and regulation of iron uptake, respectively.	Iron	265-269	beta-2-microglobulin	Homo sapiens	32-52
19416716-4	2009	The identification of FPN1B reveals how FPN1 expression can bypass IRP-dependent repression in intestinal iron uptake, even when cells throughout the body are iron deficient.	Iron	106-110	solute carrier family 40 member 1	Homo sapiens	22-26
11755534-1	2002	A divalent metal transporter, DMT1, located on the apical membrane of intestinal enterocytes is the major pathway for the absorption of dietary non-haem iron.	Iron	153-157	solute carrier family 11 member 2	Homo sapiens	30-34
19416716-4	2009	The identification of FPN1B reveals how FPN1 expression can bypass IRP-dependent repression in intestinal iron uptake, even when cells throughout the body are iron deficient.	Iron	159-163	solute carrier family 40 member 1	Homo sapiens	22-26
11755534-2	2002	Using human intestinal Caco-2 TC7 cells, we have shown that iron uptake and DMT1 protein in the plasma membrane were significantly decreased by exposure to high iron for 24 h, in a concentration-dependent manner, whereas whole cell DMT1 protein abundance was unaltered.	Iron	161-165	solute carrier family 11 member 2	Homo sapiens	76-80
19318940-6	2009	Lactoferrin has also been shown to enhance iron status of infants and pregnant women, possibly also via the receptor-mediated pathway.	Iron	43-47	lactotransferrin	Bos taurus	0-11
11755534-2	2002	Using human intestinal Caco-2 TC7 cells, we have shown that iron uptake and DMT1 protein in the plasma membrane were significantly decreased by exposure to high iron for 24 h, in a concentration-dependent manner, whereas whole cell DMT1 protein abundance was unaltered.	Iron	161-165	solute carrier family 11 member 2	Homo sapiens	232-236
11755534-3	2002	This suggests that part of the response to high iron involved redistribution of DMT1 between the cytosol and cell membrane.	Iron	48-52	solute carrier family 11 member 2	Homo sapiens	80-84
11755534-4	2002	These events preceded changes in DMT1 mRNA, which was only decreased following 72 h exposure to high iron.	Iron	101-105	solute carrier family 11 member 2	Homo sapiens	33-37
19318940-10	2009	SUMMARY: Lactoferrin treatment may have beneficial preventive and therapeutic effects on infection, inflammation, and cancer as well as enhancing iron status and growth in vulnerable groups.	Iron	146-150	lactotransferrin	Bos taurus	9-20
19286879-1	2009	Low levels of hepcidin are responsible for the development of iron overload in p.Cys282Tyr HFE related hemochromatosis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	14-22
12055353-5	2002	Characterization of this disorder revealed a critical physiological role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and has provided new insights into human iron metabolism and nutrition.	Iron	118-122	ceruloplasmin	Homo sapiens	77-90
12055353-5	2002	Characterization of this disorder revealed a critical physiological role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and has provided new insights into human iron metabolism and nutrition.	Iron	158-162	ceruloplasmin	Homo sapiens	77-90
12012432-2	2002	The H93G myoglobin cavity mutant is shown to be capable of forming mixed ligand adducts because of the difference in accessibility of the two sides of the ferric heme iron.	Iron	167-171	myoglobin	Homo sapiens	9-18
19286879-3	2009	Based on this hypothesis, we identified a heterozygous nc.-153 C&gt;T mutation in the hepcidin gene promoter sequence in a patient homozygous for the p.Cys282Tyr HFE mutation who presented massive iron overload, resisting to well conducted iron depletive treatment.	Iron	197-201	hepcidin antimicrobial peptide	Homo sapiens	86-94
19286879-3	2009	Based on this hypothesis, we identified a heterozygous nc.-153 C&gt;T mutation in the hepcidin gene promoter sequence in a patient homozygous for the p.Cys282Tyr HFE mutation who presented massive iron overload, resisting to well conducted iron depletive treatment.	Iron	240-244	hepcidin antimicrobial peptide	Homo sapiens	86-94
19286879-5	2009	In conclusion, our results suggest that a mutation in the BMP-RE of hepcidin promoter may impact on human iron metabolism.	Iron	106-110	bone morphogenetic protein 1	Homo sapiens	58-61
19286879-5	2009	In conclusion, our results suggest that a mutation in the BMP-RE of hepcidin promoter may impact on human iron metabolism.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	68-76
11804665-0	2002	Serum ceruloplasmin and ferroxidase activity are decreased in HFE C282Y homozygote male iron-overloaded patients.	Iron	88-92	ceruloplasmin	Homo sapiens	6-19
19444013-2	2009	Inappropriate low secretion of hepcidin, which negatively regulates iron absorption, is postulated to be the mechanism for iron overload in this condition.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	31-39
11804665-1	2002	BACKGROUND/AIMS: A body of evidence suggests that ceruloplasmin (Cp), the major serum copper-containing protein, acts in iron metabolism due to its ferroxidase activity which appears essential for iron movements and exchanges.	Iron	121-125	ceruloplasmin	Homo sapiens	50-63
11804665-1	2002	BACKGROUND/AIMS: A body of evidence suggests that ceruloplasmin (Cp), the major serum copper-containing protein, acts in iron metabolism due to its ferroxidase activity which appears essential for iron movements and exchanges.	Iron	197-201	ceruloplasmin	Homo sapiens	50-63
19444013-2	2009	Inappropriate low secretion of hepcidin, which negatively regulates iron absorption, is postulated to be the mechanism for iron overload in this condition.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	31-39
19388095-4	2009	For AD tissues, T(2) (*) contrast of Abeta-plaques was directly associated with the gradation of iron concentration.	Iron	97-101	amyloid beta (A4) precursor protein	Mus musculus	37-42
12688510-0	2002	Iron uptake by melanoma cells from the soluble form of the transferrin homologue, melanotransferrin.	Iron	0-4	melanotransferrin	Homo sapiens	82-99
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	41-45	Fit3p	Saccharomyces cerevisiae S288C	16-20
19250338-6	2009	Thus, HO-1 activity promotes mitochondrial macroautophagy and sequestration of redox-active iron in astroglia independently of classical iron mobilization pathways.	Iron	92-96	heme oxygenase 1	Homo sapiens	6-10
19250338-6	2009	Thus, HO-1 activity promotes mitochondrial macroautophagy and sequestration of redox-active iron in astroglia independently of classical iron mobilization pathways.	Iron	137-141	heme oxygenase 1	Homo sapiens	6-10
11843825-5	2001	ABC7 encodes a mitochondrial half-type ATP Binding Cassette transporter involved in iron homeostasis.	Iron	84-88	ATP binding cassette subfamily B member 7	Homo sapiens	0-4
19250338-7	2009	Glial HO-1 may be a rational therapeutic target in AD, PD, and other human CNS conditions characterized by the unregulated deposition of brain iron.	Iron	143-147	heme oxygenase 1	Homo sapiens	6-10
19386032-0	2009	Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	59-67
11688986-8	2001	This suggests that transition metal such as iron may play a role in regulation of HIF-2alpha in vivo.	Iron	44-48	endothelial PAS domain protein 1	Homo sapiens	82-92
11721763-1	2001	OBJECTIVES: There is accumulating evidence that ceruloplasmin, a copper protein with ferroxidase activity, plays an important role in iron metabolism.	Iron	134-138	ceruloplasmin	Homo sapiens	48-61
19261733-9	2009	Characterization of succinate dehydrogenase activity in embryos from two homozygous sdh2-3 mutant lines permits us to conclude that SDH2-3 is the major iron-sulfur subunit of mature embryo complex II.	Iron	152-156	succinate dehydrogenase 2-3	Arabidopsis thaliana	132-138
19304929-0	2009	The analysis of Arabidopsis nicotianamine synthase mutants reveals functions for nicotianamine in seed iron loading and iron deficiency responses.	Iron	103-107	nicotianamine synthase	Arabidopsis thaliana	28-50
11591684-4	2001	Furthermore, when pigA was disrupted by cassette mutagenesis in P. aeruginosa, heme utilization was defective in iron-poor media supplemented with heme.	Iron	113-117	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	18-22
19304929-14	2009	These results are fundamental for plant manipulation approaches to modify Fe homeostasis regulation through alterations of NAS genes.	Iron	74-76	nicotianamine synthase	Arabidopsis thaliana	123-126
11606717-8	2001	The megalin-dependent, cubilin-mediated endocytosis of Tf and the potential of the receptors thereby to facilitate iron uptake were further confirmed by analyzing the uptake of (125)I- and (59)Fe-labeled Tf in cultured yolk sac cells.	Iron	115-119	low density lipoprotein receptor-related protein 2	Mus musculus	4-11
19204324-1	2009	Hepcidin, a key regulator of iron metabolism, is a small antimicrobial peptide produced by the liver that regulates intestinal iron absorption and iron recycling by macrophages.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
11606717-8	2001	The megalin-dependent, cubilin-mediated endocytosis of Tf and the potential of the receptors thereby to facilitate iron uptake were further confirmed by analyzing the uptake of (125)I- and (59)Fe-labeled Tf in cultured yolk sac cells.	Iron	193-195	low density lipoprotein receptor-related protein 2	Mus musculus	4-11
11595385-4	2001	The stoichiometry of Fe(II) oxidation by apoferritin in an unbuffered solution of 50 mM NaCl, pH 7.0, was approximately 3.1 Fe(II)/O(2) at all iron-to-protein ratios tested.	Iron	143-147	ferritin heavy chain 1	Homo sapiens	41-52
19204324-1	2009	Hepcidin, a key regulator of iron metabolism, is a small antimicrobial peptide produced by the liver that regulates intestinal iron absorption and iron recycling by macrophages.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	0-8
19204324-1	2009	Hepcidin, a key regulator of iron metabolism, is a small antimicrobial peptide produced by the liver that regulates intestinal iron absorption and iron recycling by macrophages.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	0-8
19204324-2	2009	Hepcidin is stimulated when iron stores increase and during inflammation and, conversely, is inhibited by hypoxia and augmented erythropoiesis.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	0-8
19204324-3	2009	In many pathologic situations, such as in the anemia of chronic disease (ACD) and iron-loading anemias, several of these factors may be present concomitantly and may generate opposing signaling to regulate hepcidin expression.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	206-214
11557513-0	2001	Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins.	Iron	81-85	hephaestin	Rattus norvegicus	47-57
19204324-5	2009	We show that erythropoiesis drive, stimulated by erythropoietin but not hypoxia, down-regulates hepcidin in a dose-dependent manner, even in the presence of lipopolysaccharide (LPS) or dietary iron-loading, which may act additively.	Iron	193-197	hepcidin antimicrobial peptide	Homo sapiens	96-104
11557513-1	2001	The membrane-bound ceruloplasmin homolog hephaestin plays a critical role in intestinal iron absorption.	Iron	88-92	hephaestin	Rattus norvegicus	41-51
19321419-0	2009	Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo.	Iron	50-54	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
11557513-6	2001	Variations in iron status had a small but nonsignificant effect on hephaestin expression in the duodenum.	Iron	14-18	hephaestin	Rattus norvegicus	67-77
11673399-2	2001	Identification of HFE, the gene most commonly mutated in patients with hereditary hemochromatosis, has allowed molecular diagnosis and paved the way for identification of other genes, such as TFR2, that are important in non-HFE-associated iron overload.	Iron	239-243	transferrin receptor 2	Homo sapiens	192-196
11673399-4	2001	In parallel, our understanding of iron transport has expanded through identification of Fpn1/Ireg1/MTP1, Sfxn1 and DCYTB: Ongoing studies of Friedreich"s ataxia, sideroblastic anemia, aceruloplasminemia and neurodegeneration with brain-iron accumulation are clarifying the role for iron in the nervous system.	Iron	34-38	solute carrier family 40 member 1	Homo sapiens	88-92
19321419-2	2009	We hypothesized that macrophage Nramp1 may participate in the recycling of iron acquired from phagocytosed senescent erythrocytes.	Iron	75-79	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	32-38
11673399-4	2001	In parallel, our understanding of iron transport has expanded through identification of Fpn1/Ireg1/MTP1, Sfxn1 and DCYTB: Ongoing studies of Friedreich"s ataxia, sideroblastic anemia, aceruloplasminemia and neurodegeneration with brain-iron accumulation are clarifying the role for iron in the nervous system.	Iron	34-38	solute carrier family 40 member 1	Homo sapiens	93-98
19321419-9	2009	These data imply that without Nramp1, iron accumulates within the liver and spleen during erythrophagocytosis and hemolytic anemia, supporting our hypothesis that Nramp1 promotes efficient hemoglobin iron recycling in macrophages.	Iron	38-42	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	163-169
19321419-9	2009	These data imply that without Nramp1, iron accumulates within the liver and spleen during erythrophagocytosis and hemolytic anemia, supporting our hypothesis that Nramp1 promotes efficient hemoglobin iron recycling in macrophages.	Iron	200-204	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	163-169
19211819-0	2009	Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	7-15
11461924-7	2001	Hepatic iron was elevated 3.5-fold in aceruloplasminemic mice because of the loss of ferroxidase function.	Iron	8-12	ceruloplasmin	Mus musculus	85-96
19211819-1	2009	BACKGROUND: Iron absorption is proposed to be regulated by circulating hepcidin, but, to date, little data are available to evaluate this relation in humans.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	71-79
11572959-7	2001	Macrophage-inducible NOS generates NO to kill other cells, whereas HO1 generates bilirubin to exert antioxidant cytoprotective effects and also provides cytoprotection by facilitating iron extrusion from cells.	Iron	184-188	heme oxygenase 1	Homo sapiens	67-70
19211819-2	2009	OBJECTIVE: Stored samples from a human iron absorption study were used to test the hypothesis that differences in plasma hepcidin explain interindividual variation in iron absorption.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	121-129
11502556-5	2001	Increased uptake of Fe and Cd was observed in the HEK-293 cell line overexpressing DMT1.	Iron	20-22	solute carrier family 11 member 2	Homo sapiens	83-87
19211819-4	2009	RESULTS: Log iron absorption was negatively correlated with serum ferritin (r = -0.59, P &lt; 0.001) and with plasma hepcidin (r = -0.55, P &lt; 0.001) but was unaffected by genotype.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	117-125
19211819-6	2009	Multiple linear regression models showed that plasma hepcidin in isolation significantly predicted 36% of the interindividual variation in iron absorption.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	53-61
19211819-7	2009	CONCLUSIONS: Plasma hepcidin and serum ferritin concentrations are highly correlated, and, in the normal range of plasma hepcidin values, 36% of interindividual differences in iron absorption are explained by differences in circulating plasma hepcidin.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	20-28
11531596-4	2001	We also show that the decrease of the observed moment in magnetization measurements from the theoretically expected value is driven by the presence of mis-site disorder between Fe and Mo sites.	Iron	177-179	anti-Mullerian hormone	Homo sapiens	151-154
19211819-7	2009	CONCLUSIONS: Plasma hepcidin and serum ferritin concentrations are highly correlated, and, in the normal range of plasma hepcidin values, 36% of interindividual differences in iron absorption are explained by differences in circulating plasma hepcidin.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	121-129
19211819-7	2009	CONCLUSIONS: Plasma hepcidin and serum ferritin concentrations are highly correlated, and, in the normal range of plasma hepcidin values, 36% of interindividual differences in iron absorption are explained by differences in circulating plasma hepcidin.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	121-129
18820912-3	2009	The main objective of this work was to study the role of variants in the SLC40A1 gene in the severity of iron overload and his clinical consequences in 100 Spanish probands homozygous for the C282Y mutation of the HFE gene.	Iron	105-109	solute carrier family 40 member 1	Homo sapiens	73-80
11395492-4	2001	However, here we demonstrate that (a) the iron-sulfur center-dependent reductions of plastocyanin and P700 are much faster than cytochrome f reduction, both in Chlamydomonas reinhardtii cytochrome f mutants and in the wild type, and (b) the steady-state photosynthetic electron transport does not correlate with strongly inhibited cytochrome f reduction kinetics in the mutants.	Iron	42-46	cytochrome f	Chlamydomonas reinhardtii	186-198
11395492-4	2001	However, here we demonstrate that (a) the iron-sulfur center-dependent reductions of plastocyanin and P700 are much faster than cytochrome f reduction, both in Chlamydomonas reinhardtii cytochrome f mutants and in the wild type, and (b) the steady-state photosynthetic electron transport does not correlate with strongly inhibited cytochrome f reduction kinetics in the mutants.	Iron	42-46	cytochrome f	Chlamydomonas reinhardtii	186-198
18820912-5	2009	We studied the association between polymorphisms in the SLC40A1 gene and median values of iron removed, taking into account statistical corrections for multiple comparisons.	Iron	90-94	solute carrier family 40 member 1	Homo sapiens	56-63
19136476-9	2009	We hypothesize that excess iron, released as a consequence HO-1 activity induced by 15d-PGJ2, is transiently available for the stimulation of intracellular ROS generation and subsequently MMP-1 expression.	Iron	27-31	heme oxygenase 1	Homo sapiens	59-63
19136476-9	2009	We hypothesize that excess iron, released as a consequence HO-1 activity induced by 15d-PGJ2, is transiently available for the stimulation of intracellular ROS generation and subsequently MMP-1 expression.	Iron	27-31	matrix metallopeptidase 1	Homo sapiens	188-193
19136476-10	2009	15d-PGJ2-mediated upregulation of MMP-1 expression was blocked by the iron chelator desferrioxamine and the Fe2+-specific chelator 1,10-phenanthroline.	Iron	70-74	matrix metallopeptidase 1	Homo sapiens	34-39
11498794-0	2001	Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines.	Iron	39-43	pleiomorphic adenoma gene-like 2	Mus musculus	15-21
11498794-10	2001	We propose that PLAGL2 is involved in the cell cycle arrest and apoptosis of tumor cells by regulating iron depletion- or hypoxia-inducible gene expression.	Iron	103-107	pleiomorphic adenoma gene-like 2	Mus musculus	16-22
19136476-12	2009	In conclusion, 15d-PGJ2 upregulates MMP-1 expression via induction of HO-1 and subsequent production of iron capable of generating ROS, which may contribute to increased metastasis and invasiveness of the human breast cancer cells.	Iron	104-108	matrix metallopeptidase 1	Homo sapiens	36-41
19292870-1	2009	Recent discoveries have indicated that the hormone hepcidin plays a major role in the control of iron homeostasis.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	51-59
19292870-2	2009	Hepcidin regulates the iron level in the blood through the interaction with ferroportin, an iron exporter molecule, causing its internalization and degradation.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
11471056-5	2001	The gene ATP6H, for human vacuolar proton-ATPase subunit M9.2, is associated with copper and iron transport in yeast and has been mapped to HAS2p21 and suggested as a candidate gene for CT. We cloned canine ATP6H, which encodes a predicted protein with 99% amino acid sequence identity to the orthologous human protein.	Iron	93-97	ATPase H+ transporting V0 subunit e1	Homo sapiens	9-14
11471056-5	2001	The gene ATP6H, for human vacuolar proton-ATPase subunit M9.2, is associated with copper and iron transport in yeast and has been mapped to HAS2p21 and suggested as a candidate gene for CT. We cloned canine ATP6H, which encodes a predicted protein with 99% amino acid sequence identity to the orthologous human protein.	Iron	93-97	ATPase H+ transporting V0 subunit e1	Homo sapiens	26-61
19292870-2	2009	Hepcidin regulates the iron level in the blood through the interaction with ferroportin, an iron exporter molecule, causing its internalization and degradation.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	0-8
19292870-3	2009	As a result, hepcidin increases cellular iron sequestration, and decreases the iron concentration in the plasma.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	13-21
19292870-3	2009	As a result, hepcidin increases cellular iron sequestration, and decreases the iron concentration in the plasma.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	13-21
18951995-4	2009	Whereas, caspase 3 activation appeared to be a direct effect of resveratrol, caspase 6 activation was mediated via intracellular hydrogen peroxide production and iron.	Iron	162-166	caspase 6	Homo sapiens	77-86
11514223-2	2001	NRAMP2 (DMT1) acts as an iron-uptake protein in both the duodenum and in peripheral tissues.	Iron	25-29	solute carrier family 11 member 2	Homo sapiens	0-6
11514223-2	2001	NRAMP2 (DMT1) acts as an iron-uptake protein in both the duodenum and in peripheral tissues.	Iron	25-29	solute carrier family 11 member 2	Homo sapiens	8-12
19252486-0	2009	BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.	Iron	62-66	bone morphogenetic protein 6	Mus musculus	0-4
11423158-0	2001	Rethinking the role of ceruloplasmin in brain iron metabolism.	Iron	46-50	ceruloplasmin	Homo sapiens	23-36
11423158-1	2001	For more than three decades, it has been widely accepted that ceruloplasmin plays an important role in iron efflux from mammalian cells, including brain cells, via the activity of ferroxidase.	Iron	103-107	ceruloplasmin	Homo sapiens	62-75
11423158-2	2001	However, in light of recent findings, this view might not be completely accurate and the role of ceruloplasmin in brain iron metabolism may need to be re-evaluated.	Iron	120-124	ceruloplasmin	Homo sapiens	97-110
11423158-3	2001	Based on recent studies, we propose in this article that the role of ceruloplasmin in iron uptake by brain neuronal cells might be more important than its role in iron release from the cells.	Iron	86-90	ceruloplasmin	Homo sapiens	69-82
11423158-4	2001	A possible explanation of why the absence of ceruloplasmin induces excessive iron accumulation in neurons in aceruloplasminemia (ceruloplasmin gene mutations) was also discussed.	Iron	77-81	ceruloplasmin	Homo sapiens	45-58
11423158-4	2001	A possible explanation of why the absence of ceruloplasmin induces excessive iron accumulation in neurons in aceruloplasminemia (ceruloplasmin gene mutations) was also discussed.	Iron	77-81	ceruloplasmin	Homo sapiens	110-123
19252486-5	2009	In vivo, HJV.Fc or a neutralizing antibody to BMP6 inhibits hepcidin expression and increases serum iron, whereas DRAGON.Fc has no effect.	Iron	100-104	bone morphogenetic protein 6	Mus musculus	46-50
19252486-6	2009	Notably, Bmp6-null mice have a phenotype resembling hereditary hemochromatosis, with reduced hepcidin expression and tissue iron overload.	Iron	124-128	bone morphogenetic protein 6	Mus musculus	9-13
19252486-7	2009	Finally, we demonstrate a physical interaction between HJV.Fc and BMP6, and we show that BMP6 increases hepcidin expression and reduces serum iron in mice.	Iron	142-146	bone morphogenetic protein 6	Mus musculus	89-93
19252486-8	2009	These data support a key role for BMP6 as a ligand for hemojuvelin and an endogenous regulator of hepcidin expression and iron metabolism in vivo.	Iron	122-126	bone morphogenetic protein 6	Mus musculus	34-38
11472372-1	2001	As ceruloplasmin (Cp) seems to be involved in iron mobilization, serum Cp levels were measured in 35 patients with hereditary haemochromatosis (HH), 12 with acquired iron overload (AIO) and 36 healthy subjects.	Iron	46-50	ceruloplasmin	Homo sapiens	3-16
19338078-1	2009	The small liver peptide hepcidin is a major regulator of systemic iron homeostasis in mammals, adapting iron absorption to the body"s demands.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	24-32
19338078-1	2009	The small liver peptide hepcidin is a major regulator of systemic iron homeostasis in mammals, adapting iron absorption to the body"s demands.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	24-32
11404470-9	2001	These studies suggest that phenserine reduces Abeta levels by regulating betaAPP translation via the recently described iron regulatory element in the 5"-untranslated region of betaAPP mRNA, which has been shown previously to be up-regulated in the presence of interleukin-1.	Iron	120-124	interleukin 1 alpha	Homo sapiens	261-274
19405934-2	2009	The aim of the present study was to determine serum levels of the 60 aa pro-hormone form of hepcidin (pro-hepcidin) in full-term and preterm newborns with sepsis and to determine the possible relationships between pro-hepcidin levels and serum iron and complete blood count parameters.	Iron	244-248	hepcidin antimicrobial peptide	Homo sapiens	92-100
11278898-0	2001	A novel plant ferritin subunit from soybean that is related to a mechanism in iron release.	Iron	78-82	ferritin-1, chloroplastic	Glycine max	14-22
11278898-1	2001	Ferritin is a multimeric iron storage protein composed of 24 subunits.	Iron	25-29	ferritin-1, chloroplastic	Glycine max	0-8
19258503-5	2009	We show that inhibition of constitutively active NF-kappaB causes down-regulation of ferritin heavy chain (FHC) that leads to an increase of free intracellular iron, which, in turn, induces massive generation of ROS.	Iron	160-164	ferritin heavy chain 1	Homo sapiens	85-105
11338206-3	2001	Melatonin (100 microM) significantly reduced the appearance of condensed chromatin, redox active iron, heme-oxygenase-1 induction and 8-hydroxyguanosine immunoreactivity caused by 50 microM A beta.	Iron	97-101	amyloid beta (A4) precursor protein	Mus musculus	190-196
19258503-5	2009	We show that inhibition of constitutively active NF-kappaB causes down-regulation of ferritin heavy chain (FHC) that leads to an increase of free intracellular iron, which, in turn, induces massive generation of ROS.	Iron	160-164	ferritin heavy chain 1	Homo sapiens	107-110
19234114-1	2009	Hepcidin is a hormone secreted in response to iron loading and inflammation.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
11320327-1	2001	Contrary to the expectation of chemists, the first X-ray structures of carbon monoxide bound to myoglobin (Mb) showed a highly distorted Fe-C-O bond system.	Iron	137-139	myoglobin	Homo sapiens	96-105
11313311-0	2001	Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload.	Iron	27-31	solute carrier family 40 member 1	Homo sapiens	78-91
11313311-2	2001	The identification of divalent-metal transporter 1 (DMT1) and ferroportin 1 (FP1) has improved our understanding of transmembrane iron trafficking.	Iron	130-134	solute carrier family 11 member 2	Homo sapiens	22-50
19234114-2	2009	Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus preventing iron entry into plasma.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
11313311-2	2001	The identification of divalent-metal transporter 1 (DMT1) and ferroportin 1 (FP1) has improved our understanding of transmembrane iron trafficking.	Iron	130-134	solute carrier family 11 member 2	Homo sapiens	52-56
11313311-2	2001	The identification of divalent-metal transporter 1 (DMT1) and ferroportin 1 (FP1) has improved our understanding of transmembrane iron trafficking.	Iron	130-134	solute carrier family 40 member 1	Homo sapiens	62-75
19234114-2	2009	Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus preventing iron entry into plasma.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	0-8
11313311-2	2001	The identification of divalent-metal transporter 1 (DMT1) and ferroportin 1 (FP1) has improved our understanding of transmembrane iron trafficking.	Iron	130-134	solute carrier family 40 member 1	Homo sapiens	77-80
19234114-7	2009	These results provide a molecular explanation for the dominant inheritance of hepcidin resistant iron overload disease.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	78-86
11313311-6	2001	Moreover, DMT1 and FP1 mRNA levels were significantly increased in patients with iron deficiency, HFE and non-HFE hemochromatosis, whereas they were unchanged in patients with secondary iron overload.	Iron	81-85	solute carrier family 11 member 2	Homo sapiens	10-14
11313311-6	2001	Moreover, DMT1 and FP1 mRNA levels were significantly increased in patients with iron deficiency, HFE and non-HFE hemochromatosis, whereas they were unchanged in patients with secondary iron overload.	Iron	81-85	solute carrier family 40 member 1	Homo sapiens	19-22
19120353-0	2009	Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	48-56
11313311-8	2001	In patients with normal iron status or iron deficiency, significant negative correlations between DMT1, FP1 mRNA, and serum iron parameters were found, which were absent in subjects with primary hemochromatosis.	Iron	39-43	solute carrier family 11 member 2	Homo sapiens	98-102
11313311-8	2001	In patients with normal iron status or iron deficiency, significant negative correlations between DMT1, FP1 mRNA, and serum iron parameters were found, which were absent in subjects with primary hemochromatosis.	Iron	39-43	solute carrier family 40 member 1	Homo sapiens	104-107
11313311-9	2001	CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	13-17
11313311-9	2001	CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload.	Iron	52-56	solute carrier family 40 member 1	Homo sapiens	22-25
11313311-9	2001	CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload.	Iron	120-124	solute carrier family 11 member 2	Homo sapiens	13-17
11313311-9	2001	CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload.	Iron	120-124	solute carrier family 40 member 1	Homo sapiens	22-25
11292760-1	2001	Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation.	Iron	24-28	lactotransferrin	Bos taurus	6-17
11292760-13	2001	The binding of lactoferrin to S. pneumoniae might provide a way for the bacteria to interfere with host immune functions or to aid in the acquisition of iron at the site of infection.	Iron	153-157	lactotransferrin	Bos taurus	15-26
12604021-1	2001	Bovine lactoferrin (BLf) is an iron binding protein folded in two lobes, N- and C-lobes.	Iron	31-35	lactotransferrin	Bos taurus	7-18
11382544-7	2001	Soluble iron (dialyzed) and zinc (non-dialyzed) were higher (p &lt; 0.001) in LIF than PIF after in vitro digestion.	Iron	8-12	PIF1 5'-to-3' DNA helicase	Homo sapiens	87-90
11359564-3	2001	We have identified two Streptococcus pneumoniae genetic loci, pit1 and pit2, encoding homologues of ABC iron transporters that are required for iron uptake by this organism.	Iron	104-108	solute carrier family 20, member 2	Mus musculus	71-75
11295442-7	2001	It is shown that a different distance from Trp14 to haem iron in the three proteins might be the structural basis for the different yield of the peroxyl radical and the different efficiency of incorporation of molecular oxygen into styrene.	Iron	57-61	thioredoxin domain containing 17	Homo sapiens	43-48
11457012-5	2001	These results indicate that the heme iron of myoglobin in the film is the ferric low-spin state, and the iron atom is pulled to the heme plane.	Iron	37-41	myoglobin	Homo sapiens	45-54
11457012-5	2001	These results indicate that the heme iron of myoglobin in the film is the ferric low-spin state, and the iron atom is pulled to the heme plane.	Iron	105-109	myoglobin	Homo sapiens	45-54
11297622-4	2001	Tf bound IGFBP-3 but had negligible affinity to the other five IGFBPs, and iron-saturated holo-Tf bound IGFBP-3 more avidly than unsaturated Tf.	Iron	75-79	insulin like growth factor binding protein 3	Homo sapiens	104-111
11120744-9	2001	We propose that Fre3p and Fre4p are siderophore-iron reductases and that the apparent redundancy of the FRE genes confers the capacity to utilize iron from a variety of siderophore sources.	Iron	48-52	ferric-chelate reductase	Saccharomyces cerevisiae S288C	16-21
11231303-5	2001	Through its ferroxidase activity Cp is involved prominently in iron metabolism.	Iron	63-67	ceruloplasmin	Mus musculus	12-23
11160325-6	2001	Fes appears to be a downstream kinase from Jak1/Jak3 in this process.	Iron	0-3	Janus kinase 3	Homo sapiens	48-52
11422224-3	2001	Accurate diagnosis of CDA II is important to prevent severe iron overload.	Iron	60-64	SEC23 homolog B, COPII coat complex component	Homo sapiens	22-28
11425282-8	2001	Moreover, the high levels of Fe found in the substantia nigra of PD patients may perhaps be explained by free Cu binding to iron binding protein-1 (IBP-1), causing it to malfunction and preventing it from detaching itself from the transferrin receptor (TfR) inhibition gene, resulting in expression of TfR even when the cell has plenty of Fe.	Iron	29-31	insulin like growth factor binding protein 1	Homo sapiens	124-146
11425282-8	2001	Moreover, the high levels of Fe found in the substantia nigra of PD patients may perhaps be explained by free Cu binding to iron binding protein-1 (IBP-1), causing it to malfunction and preventing it from detaching itself from the transferrin receptor (TfR) inhibition gene, resulting in expression of TfR even when the cell has plenty of Fe.	Iron	29-31	insulin like growth factor binding protein 1	Homo sapiens	148-153
11425282-8	2001	Moreover, the high levels of Fe found in the substantia nigra of PD patients may perhaps be explained by free Cu binding to iron binding protein-1 (IBP-1), causing it to malfunction and preventing it from detaching itself from the transferrin receptor (TfR) inhibition gene, resulting in expression of TfR even when the cell has plenty of Fe.	Iron	339-341	insulin like growth factor binding protein 1	Homo sapiens	124-146
11425282-8	2001	Moreover, the high levels of Fe found in the substantia nigra of PD patients may perhaps be explained by free Cu binding to iron binding protein-1 (IBP-1), causing it to malfunction and preventing it from detaching itself from the transferrin receptor (TfR) inhibition gene, resulting in expression of TfR even when the cell has plenty of Fe.	Iron	339-341	insulin like growth factor binding protein 1	Homo sapiens	148-153
11358388-0	2001	Transferrin receptor-2 (TFR2) mutation Y250X in Alabama Caucasian and African American subjects with and without primary iron overload.	Iron	121-125	transferrin receptor 2	Homo sapiens	0-22
11358388-0	2001	Transferrin receptor-2 (TFR2) mutation Y250X in Alabama Caucasian and African American subjects with and without primary iron overload.	Iron	121-125	transferrin receptor 2	Homo sapiens	24-28
11358389-0	2001	Mutation analysis of the transferrin receptor-2 gene in patients with iron overload.	Iron	70-74	transferrin receptor 2	Homo sapiens	25-47
11358389-1	2001	Three mutations in the transferrin receptor-2 gene have recently been identified in four Sicilian families with iron overload who had a normal hemochromatosis gene, HFE (C. Camaschella, personal communication).	Iron	112-116	transferrin receptor 2	Homo sapiens	23-45
11358389-2	2001	To determine the extent to which mutations in the transferrin receptor-2 gene occur in other populations with iron overload, we have completely sequenced this gene in 17 whites, 10 Asians, and 8 African Americans with iron overload and a C282C/C282C HFE genotype, as well as 4 subjects without iron overload and homozygous for the mutant HFE C282Y genotype, 5 patients with iron overload and homozygous for the mutant HFE C282Y genotype, and 5 normal individuals.	Iron	110-114	transferrin receptor 2	Homo sapiens	50-72
11358390-7	2001	The TFR2 gene is a transferrin receptor gene homologue that seems to be involved in iron metabolism.	Iron	84-88	transferrin receptor 2	Homo sapiens	4-8
19120353-2	2009	Growth differentiation factor 15 (GDF15) has been identified as a bone marrow-derived factor that abrogates hepcidin-mediated protection from iron overload under conditions of increased erythropoiesis.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	108-116
19176287-2	2009	To determine the association of mutations within the HCP1 gene with iron phenotypes, we examined the entire coding region of the HCP1 gene in 788 US and Canadian participants selected from the Hemochromatosis and Iron Overload Screening (HEIRS) Study using denaturing high-performance liquid chromatography.	Iron	68-72	solute carrier family 46 member 1	Homo sapiens	53-57
19254564-0	2009	Iron sensing as a partnership: HFE and transferrin receptor 2.	Iron	0-4	transferrin receptor 2	Homo sapiens	39-61
19254567-4	2009	Hepcidin, a hepatic peptide hormone, negatively regulates iron efflux from the intestines into the blood.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
19254567-5	2009	We report two hepatic cell lines, WIF-B cells and HepG2 cells transfected with HFE, where hepcidin expression responded to iron-loaded transferrin.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	90-98
19399246-0	2009	Physiological and pathological role of alpha-synuclein in Parkinson"s disease through iron mediated oxidative stress; the role of a putative iron-responsive element.	Iron	86-90	synuclein alpha	Homo sapiens	39-54
19399246-3	2009	Dysfunction of alpha-synuclein (alpha-syn) has been associated with PD due to its increased presence, together with iron, in Lewy bodies.	Iron	116-120	synuclein alpha	Homo sapiens	15-30
19399246-3	2009	Dysfunction of alpha-synuclein (alpha-syn) has been associated with PD due to its increased presence, together with iron, in Lewy bodies.	Iron	116-120	synuclein alpha	Homo sapiens	15-24
19399246-4	2009	Brain oxidative damage caused by iron may be partly mediated by alpha-syn oligomerization during PD pathology.	Iron	33-37	synuclein alpha	Homo sapiens	64-73
19399246-5	2009	Also, alpha-syn gene dosage can cause familial PD and inhibition of its gene expression by blocking translation via a newly identified Iron Responsive Element-like RNA sequence in its 5"-untranslated region may provide a new PD drug target.	Iron	135-139	synuclein alpha	Homo sapiens	6-15
19135260-0	2009	Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand.	Iron	115-119	heme oxygenase 1	Homo sapiens	49-65
19025353-5	2009	The goal of this study was to clarify the relationship between iron overload and AQP4 expression and to characterize the effects of the iron chelator deferoxamine (DFO) on delayed brain edema after experimental ICH.	Iron	63-67	aquaporin 4	Rattus norvegicus	81-85
19025353-16	2009	The application of the iron chelator DFO significantly reduced iron overload, brain water content, and AQP4 level in the perihematomal area compared with the control group.	Iron	23-27	aquaporin 4	Rattus norvegicus	103-107
19025353-18	2009	In addition, AQP4 expression was affected by iron concentration.	Iron	45-49	aquaporin 4	Rattus norvegicus	13-17
19246738-0	2009	Immune evasion by Staphylococcus aureus conferred by iron-regulated surface determinant protein IsdH.	Iron	53-57	AT695_RS08845	Staphylococcus aureus	96-100
19246738-4	2009	The IsdH protein is part of a complex that is only expressed under iron-restricted conditions in order to bind haemoglobin and extract and transport haem into the cytoplasm.	Iron	67-71	AT695_RS08845	Staphylococcus aureus	4-8
19150361-2	2009	Ferroportin-mediated iron export is controlled by the hormone hepcidin, which binds ferroportin, causing its internalization and degradation.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	62-70
19073788-0	2009	Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	6-14
19073788-1	2009	BACKGROUND: Hepcidin is a key regulator of iron homeostasis, but to date no studies have examined the effect of hepcidin on iron absorption in humans.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	12-20
19073788-2	2009	OBJECTIVE: Our objective was to assess relations between both serum hepcidin and serum prohepcidin with nonheme-iron absorption in the presence and absence of food with the use of dual stable-iron-isotope techniques.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	68-76
19073788-8	2009	Absorption of nonheme iron assessed in the presence (P = 0.038) and absence (P = 0.0296) of food was significantly associated with serum hepcidin but was not significantly related to serum prohepcidin.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	137-145
19073788-9	2009	CONCLUSION: Serum hepcidin, but not prohepcidin, was inversely associated with iron absorption from supplemental and food-based nonheme-iron sources in iron-replete healthy women.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	18-26
19073788-9	2009	CONCLUSION: Serum hepcidin, but not prohepcidin, was inversely associated with iron absorption from supplemental and food-based nonheme-iron sources in iron-replete healthy women.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	18-26
19073788-9	2009	CONCLUSION: Serum hepcidin, but not prohepcidin, was inversely associated with iron absorption from supplemental and food-based nonheme-iron sources in iron-replete healthy women.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	18-26
11405989-14	2001	The pooled difference in pre to post treatment change in Bayley Scale PDI between iron treated and placebo groups was -3.2 (95%CI -7.24, 0.85) and in Bayley Scale MDI, 0.55 (95% CI -2.84, 1.75).	Iron	82-86	peptidyl arginine deiminase 1	Homo sapiens	70-73
11405989-18	2001	Idjrandinata et al reported that the difference in pre to post treatment change in Bayley Scale PDI between iron treated and placebo groups after 4 months was 18.40 (95%CI 10.16, 26.64) and in Bayley Scale MDI, 18.80 (95% CI 10.19, 27.41).	Iron	108-112	peptidyl arginine deiminase 1	Homo sapiens	96-99
19147412-2	2009	Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators of iron absorption.	Iron	88-92	solute carrier family 11 member 2	Homo sapiens	34-62
11208917-3	2001	We have also shown that reactive iron (Fe3+) and cGMP staining spatially resemble that of HO-1; which, in turn, colocalizes in motor neurons with transcription factors: Fas-associated protein containing death domain (FADD), tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and p53.	Iron	33-37	heme oxygenase 1	Homo sapiens	90-94
19147412-2	2009	Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators of iron absorption.	Iron	88-92	solute carrier family 11 member 2	Homo sapiens	64-68
19147412-4	2009	Hypoxia-inducible factor (HIF) signaling was induced in the intestine following acute iron deficiency in the duodenum, resulting in activation of DcytB and DMT1 expression and an increase in iron uptake.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	156-160
19070395-2	2009	To investigate the effect of liver iron excess on the prevalence of hepatocellular carcinoma (HCC) in patients with NASH-related cirrhosis.	Iron	35-39	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	116-120
11302205-1	2001	DFT calculations were done for the (hydroperoxo)metal complexes with eta1-coordination mode, where metal ions are Fe(III), Al(III), Cu(II) and Zn(II).	Iron	114-116	secreted phosphoprotein 1	Homo sapiens	69-73
11188526-3	2000	Increasing alpha-substitution leads to the lengthening of the Fe-N bond, which in turn results in a change in carboxylate binding mode from eta 1 to eta 2.	Iron	62-64	secreted phosphoprotein 1	Homo sapiens	140-145
19070395-8	2009	CONCLUSIONS: Iron deposition in the liver was more frequent in patients with NASH-related cirrhosis with HCC than in HCC-free controls.	Iron	13-17	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	77-81
11027676-2	2000	A second receptor for Tf, TfR2, was recently identified and found to be functional for iron uptake in transfected cells (Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., Said, J. W., and Koeffler, H. P. (2000) J. Biol.	Iron	87-91	transferrin receptor 2	Homo sapiens	26-30
19070395-9	2009	Liver iron overload may be associated with development of HCC in patients with NASH-related cirrhosis.	Iron	6-10	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	79-83
11027676-10	2000	The affinity of TfR2 for iron-loaded Tf was determined to be 27 nm, 25-fold lower than the affinity of TfR for Tf.	Iron	25-29	transferrin receptor 2	Homo sapiens	16-20
19070915-0	2009	Iron in NASH, chronic liver diseases and HCC: how much iron is too much?	Iron	0-4	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	8-12
11097627-6	2000	Extracellular Ca(2+), Ba(2+), Cd(2+), Co(2+), Fe(2+), Gd(3+), Ni(2+), Pb(2+), and neomycin activated the CaR, but Hg(2+) and Fe(3+) did not.	Iron	125-127	CXADR pseudogene 1	Homo sapiens	105-108
19100788-3	2009	This study investigated whether the JNK signaling pathway is activated by iron after ICH.	Iron	74-78	mitogen-activated protein kinase 8	Rattus norvegicus	36-39
11169417-6	2000	Importantly, the "protective" effect of iron delivery correlated with the presence, at the site of inoculation, of lower levels of IL-4 and IL-10 transcripts while both IFN-gamma and inducible nitric oxide synthase transcripts were at higher levels.	Iron	40-44	interleukin 4	Mus musculus	131-135
19100788-8	2009	We found that activated JNK in the brain were increased after ICH, and an intracerebral infusion of ferrous iron also upregulated brain activated JNK.	Iron	100-112	mitogen-activated protein kinase 8	Rattus norvegicus	24-27
19100788-8	2009	We found that activated JNK in the brain were increased after ICH, and an intracerebral infusion of ferrous iron also upregulated brain activated JNK.	Iron	100-112	mitogen-activated protein kinase 8	Rattus norvegicus	146-149
11202004-2	2000	Because phytic acid is hydrolyzed during digestion, this work aimed to know whether its hydrolysis products (IP2, IP3, IP4, and IP5) could still prevent iron ion-induced lipid peroxidation.	Iron	153-157	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	109-112
19100788-9	2009	Free iron accumulated in CSF and systemic administration of DFX after ICH reduces free iron contents in CSF, suppresses JNK activation and improves ICH-induced neurological deficits.	Iron	5-9	mitogen-activated protein kinase 8	Rattus norvegicus	120-123
19100788-10	2009	Our results demonstrated that the JNK signaling pathway is activated after ICH and iron may contribute to this activation.	Iron	83-87	mitogen-activated protein kinase 8	Rattus norvegicus	34-37
18972320-1	2009	AIM: Hepcidin, a recently identified peptide, acts as a central regulator of iron metabolism.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	5-13
11206973-0	2000	Constitutive expression of soybean ferritin cDNA in transgenic wheat and rice results in increased iron levels in vegetative tissues but not in seeds.	Iron	99-103	ferritin-1, chloroplastic	Glycine max	35-43
11206973-1	2000	We used particle bombardment to produce transgenic wheat and rice plants expressing recombinant soybean ferritin, a protein that can store large amounts of iron.	Iron	156-160	ferritin-1, chloroplastic	Glycine max	104-112
18972320-15	2009	The reduced prohepcidin levels in the iron depleted RA patients suggests that there may be conflicting signals regulating hepcidin production in RA patients.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	15-23
11023790-12	2000	This situation is, however, different in lactoferrin, where iron loss requires a prior change in conformation.	Iron	60-64	lactotransferrin	Bos taurus	41-52
18972320-16	2009	In RA patients who have reduced hepcidin in the iron depleted group (ferritin &lt;60 microg/L) where sTfR levels are increased suggests that these patients are iron deficient.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	32-40
18972320-16	2009	In RA patients who have reduced hepcidin in the iron depleted group (ferritin &lt;60 microg/L) where sTfR levels are increased suggests that these patients are iron deficient.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	32-40
11097467-1	2000	The copper-binding protein ceruloplasmin oxidizes ferrous iron to ferric iron, an action that is critical for the binding of iron to transferrin in plasma.	Iron	50-62	ceruloplasmin	Homo sapiens	27-40
19162549-1	2009	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to bilirubin by biliverdin reductase).	Iron	103-107	heme oxygenase 1	Homo sapiens	0-16
11023535-8	2000	Our results suggest that increased sequestration of iron as a consequence of induced HO-1 might be involved in the adaptive protection after HBO treatment and that the induction of DNA damage is not the trigger for adaptive protection.	Iron	52-56	heme oxygenase 1	Homo sapiens	85-89
19162549-1	2009	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to bilirubin by biliverdin reductase).	Iron	103-107	heme oxygenase 1	Homo sapiens	18-22
19162549-1	2009	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to bilirubin by biliverdin reductase).	Iron	166-170	heme oxygenase 1	Homo sapiens	0-16
11017929-9	2000	In the reference population, male TF CD heterozygotes had significantly lower (P &lt;0.01) values for serum iron, TIBC, TF saturation, and serum iron:TF ratio than the TF CC homozygotes; in females, only TIBC was significantly different.	Iron	108-112	tubulin folding cofactor D	Homo sapiens	34-39
19162549-1	2009	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to bilirubin by biliverdin reductase).	Iron	166-170	heme oxygenase 1	Homo sapiens	18-22
11017929-9	2000	In the reference population, male TF CD heterozygotes had significantly lower (P &lt;0.01) values for serum iron, TIBC, TF saturation, and serum iron:TF ratio than the TF CC homozygotes; in females, only TIBC was significantly different.	Iron	145-149	tubulin folding cofactor D	Homo sapiens	34-39
19032104-0	2009	Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	40-48
11052766-1	2000	Lactoferrin is an iron transport protein present in human milk at an average concentration of 1.4 mg/mL.	Iron	18-22	lactotransferrin	Bos taurus	0-11
19032104-3	2009	Before initiation of antimalarial treatment, urinary concentrations of hepcidin were strongly elevated and were associated with iron maldistribution, as was suggested by the presence of hypoferremia and high serum concentrations of ferritin.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	71-79
11052766-3	2000	In addition to its role in iron transport, lactoferrin has bacteriostatic and bactericidal activities.	Iron	27-31	lactotransferrin	Bos taurus	43-54
19032104-5	2009	Exploration of regulatory pathways of hepcidin production by analysis of iron, erythropoietic, and inflammatory indices suggested that reduced erythropoietic activity and inflammation stimulated hepcidin production.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	38-46
11052766-7	2000	On the basis of all three of these determinations, lactoferrin acted as an antioxidant in the absence and presence of different concentrations of supplemented iron.	Iron	159-163	lactotransferrin	Bos taurus	51-62
11052766-8	2000	Lactoferrin inhibited oxidation in a concentration-dependent manner even at concentrations beyond its capacity to bind iron at its two high affinity binding sites.	Iron	119-123	lactotransferrin	Bos taurus	0-11
19032104-6	2009	We conclude that high concentrations of hepcidin explain the observed disturbances in host iron homeostasis associated with malaria and may contribute to malarial anemia and an impaired erythropoietic response to iron supplementation.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	40-48
19032104-6	2009	We conclude that high concentrations of hepcidin explain the observed disturbances in host iron homeostasis associated with malaria and may contribute to malarial anemia and an impaired erythropoietic response to iron supplementation.	Iron	213-217	hepcidin antimicrobial peptide	Homo sapiens	40-48
10811640-6	2000	P. gingivalis could not utilize lactoferrin for its growth as an iron source and, in contrast, lactoferrin inhibited the growth of the bacterium in a rich medium containing hemoglobin as the sole iron source.	Iron	196-200	lactotransferrin	Bos taurus	95-106
10811640-8	2000	These results suggest that lactoferrin has a bacteriostatic action on P. gingivalis by binding HbR, removing it from the cell surface, and consequently disrupting the iron uptake system from hemoglobin.	Iron	167-171	lactotransferrin	Bos taurus	27-38
18815282-6	2009	Curcumin repressed synthesis of hepcidin, a peptide that plays a central role in regulation of systemic iron balance.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	32-40
11019827-0	2000	Intact human ceruloplasmin is required for the incorporation of iron into human ferritin.	Iron	64-68	ceruloplasmin	Homo sapiens	13-26
19639462-1	2009	OBJECTIVE: To compare the effects of bovine lactoferrin with ferrous sulfate on iron nutritional status and to evaluate their tolerability in 100 pregnant women with iron deficiency anemia.	Iron	80-84	lactotransferrin	Bos taurus	44-55
11019827-2	2000	Loading iron into human ferritin using human serum ceruloplasmin is complicated by the fact that human ceruloplasmin is very susceptible to proteolysis (T. P. Ryan, T. A. Grover, and S. D. Aust, 1992, Arch.	Iron	8-12	ceruloplasmin	Homo sapiens	51-64
11019827-2	2000	Loading iron into human ferritin using human serum ceruloplasmin is complicated by the fact that human ceruloplasmin is very susceptible to proteolysis (T. P. Ryan, T. A. Grover, and S. D. Aust, 1992, Arch.	Iron	8-12	ceruloplasmin	Homo sapiens	103-116
11019827-5	2000	The present study investigated the effect of proteolysis on the ability of human ceruloplasmin to load iron into human ferritin.	Iron	103-107	ceruloplasmin	Homo sapiens	81-94
11019827-8	2000	Only the intact form of ceruloplasmin was able to catalyze iron loading into ferritin without altering the physical characteristics of the ferritin protein during the process.	Iron	59-63	ceruloplasmin	Homo sapiens	24-37
11019827-9	2000	Abnormal migration in nondenaturing PAGE gels, as well as a decrease in the amount of detectable ferritin protein, was observed when ferritin was incubated with iron alone or with proteolytically degraded ceruloplasmin and iron.	Iron	161-165	ceruloplasmin	Homo sapiens	205-218
11019827-10	2000	It was concluded that the structural integrity of ceruloplasmin is required for the enzyme to effectively catalyze iron loading into ferritin.	Iron	115-119	ceruloplasmin	Homo sapiens	50-63
19639462-13	2009	CONCLUSIONS: The results show that bovine lactoferrin has the same efficacy as ferrous sulfate in restoring iron deposits with significantly fewer gastrointestinal side effects.	Iron	108-112	lactotransferrin	Bos taurus	42-53
11053673-2	2000	Heme oxygenase-1 (HO-1) is a 32kDa stress protein that degrades heme to biliverdin, free iron and carbon monoxide.	Iron	89-93	heme oxygenase 1	Homo sapiens	0-16
18977764-6	2009	Maize YS1 is the founding member of a family of membrane transporters called YS1-like (YSL), which functions in root Fe-phytosiderophore uptake from the soil.	Iron	117-119	iron-phytosiderophore transporter yellow stripe 1	Zea mays	6-9
11053673-2	2000	Heme oxygenase-1 (HO-1) is a 32kDa stress protein that degrades heme to biliverdin, free iron and carbon monoxide.	Iron	89-93	heme oxygenase 1	Homo sapiens	18-22
11053673-4	2000	In these cells and in rat astroglia transfected with the human HO-1 gene, mitochondrial iron trapping is abrogated by the HO-1 inhibitors, tin-mesoporphyrin and dexamethasone.	Iron	88-92	heme oxygenase 1	Homo sapiens	63-67
11053673-4	2000	In these cells and in rat astroglia transfected with the human HO-1 gene, mitochondrial iron trapping is abrogated by the HO-1 inhibitors, tin-mesoporphyrin and dexamethasone.	Iron	88-92	heme oxygenase 1	Homo sapiens	122-126
11053673-7	2000	Collectively, our findings suggest that HO-1 over-expression contributes to the pathological iron deposition and mitochondrial damage documented in these aging-related neurodegenerative disorders.	Iron	93-97	heme oxygenase 1	Homo sapiens	40-44
18977764-6	2009	Maize YS1 is the founding member of a family of membrane transporters called YS1-like (YSL), which functions in root Fe-phytosiderophore uptake from the soil.	Iron	117-119	iron-phytosiderophore transporter yellow stripe 1	Zea mays	77-80
18534196-1	2009	Human lactoferrampin is a novel antimicrobial peptide found in the cationic N-terminal lobe of the iron-binding human lactoferrin protein.	Iron	99-103	lactotransferrin	Bos taurus	118-129
10964660-2	2000	In primary avian erythroblasts undergoing short-term proliferation, however, ferritin heavy chain (ferH) mRNA is repressed at all iron levels.	Iron	130-134	ferritin heavy chain 1	Homo sapiens	77-97
10964660-2	2000	In primary avian erythroblasts undergoing short-term proliferation, however, ferritin heavy chain (ferH) mRNA is repressed at all iron levels.	Iron	130-134	ferritin heavy chain 1	Homo sapiens	99-103
10964660-3	2000	Yet, expression of v-ErbA oncoprotein is sufficient to reinduce ferH mRNA utilization at physiological iron concentrations.	Iron	103-107	ferritin heavy chain 1	Homo sapiens	64-68
10964660-5	2000	Whereas endogenous c-Kit in combination with exogenous EpoR had no significant effect, ectopic overexpression of both receptors abolished translational repression of ferH mRNA upon iron administration.	Iron	181-185	ferritin heavy chain 1	Homo sapiens	166-170
19154717-0	2009	Scara5 is a ferritin receptor mediating non-transferrin iron delivery.	Iron	56-60	scavenger receptor class A member 5	Homo sapiens	0-6
10861241-1	2000	Natural resistance-associated macrophage protein 2 (Nramp2) has been suggested to be involved in transferrin-independent iron uptake.	Iron	121-125	solute carrier family 11 member 2	Homo sapiens	0-50
19154717-6	2009	Since the capsule expressed a novel receptor called Scara5, we tested its role in ferritin uptake and found that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery.	Iron	215-219	scavenger receptor class A member 5	Homo sapiens	52-58
10861241-1	2000	Natural resistance-associated macrophage protein 2 (Nramp2) has been suggested to be involved in transferrin-independent iron uptake.	Iron	121-125	solute carrier family 11 member 2	Homo sapiens	52-58
19154717-6	2009	Since the capsule expressed a novel receptor called Scara5, we tested its role in ferritin uptake and found that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery.	Iron	215-219	scavenger receptor class A member 5	Homo sapiens	113-119
20001631-5	2009	Other mechanisms that may reduce the extrahepatic iron distribution in SCD include raised plasma hepcidin due to chronic inflammation, lower growth differentiation factor 15 (GDF15) levels because of less ineffective erythropoiesis (IE), and induction of heme oxygenase (HO1) by intravascular hemolysis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	97-105
10879767-2	2000	In this study a highly refined FE model of C-2 was created and validated.	Iron	31-33	complement C2	Homo sapiens	43-46
10924274-6	2000	We hypothesize that the lesions in NPC1 and NPC2 block the intracellular utilization not only of cholesterol, but also that of iron for the synthesis of cytosolic ferritin.	Iron	127-131	NPC intracellular cholesterol transporter 1	Homo sapiens	35-39
20008200-2	2009	Dietary iron absorption is regulated locally by hypoxia inducible factor (HIF) signaling and iron-regulatory proteins (IRPs) in enterocytes and systematically by hepatic hepcidin, the central iron regulatory hormone.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	170-178
20008200-3	2009	Hepcidin not only controls the rate of iron absorption but also determines iron mobilization from stores through negatively modulating the function of ferroportin, the only identified cellular iron exporter to date.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
10747949-2	2000	This gene, termed metal transporter protein (mtp1), is expressed in tissues involved in body iron homeostasis including the developing and mature reticuloendothelial system, the duodenum, and the pregnant uterus.	Iron	93-97	solute carrier family 40 member 1	Homo sapiens	45-49
20008200-3	2009	Hepcidin not only controls the rate of iron absorption but also determines iron mobilization from stores through negatively modulating the function of ferroportin, the only identified cellular iron exporter to date.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
10747949-5	2000	Overexpression of MTP1 in tissue culture cells results in intracellular iron depletion.	Iron	72-76	solute carrier family 40 member 1	Homo sapiens	18-22
10747949-8	2000	These data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism.	Iron	36-40	solute carrier family 40 member 1	Homo sapiens	25-29
20008200-3	2009	Hepcidin not only controls the rate of iron absorption but also determines iron mobilization from stores through negatively modulating the function of ferroportin, the only identified cellular iron exporter to date.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
10747949-8	2000	These data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism.	Iron	111-115	solute carrier family 40 member 1	Homo sapiens	25-29
19293540-1	2009	OBJECTIVE: To investigate the role of circulating hepcidin, which is a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with rheumatoid arthritis.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	50-58
19046352-3	2009	In the current study, we determined the effects of HO-1 over-expression and its byproducts iron (Fe(2+)), carbon monoxide (CO) and bilirubin on CH biosynthesis, CH efflux and oxysterol formation in cultured astroglia.	Iron	91-95	heme oxygenase 1	Homo sapiens	51-55
10841535-2	2000	We have experimentally mimicked starting points in this process by introducing primitive iron and oxygen binding sites at various locations in thioredoxin, a small protein lacking metal centers, by using computational design.	Iron	89-93	thioredoxin	Homo sapiens	143-154
18946492-5	2009	Our results show that the effect of anti-hTfR IgG3-Av is iron-dependent whereas that of GA is iron-independent in all cells tested.	Iron	57-61	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	46-50
10806335-1	2000	Lactoferrin, an iron-binding protein of the transferrin family, is a highly basic protein which interacts with many acidic molecules, including heparin proteoglycans.	Iron	16-20	lactotransferrin	Bos taurus	0-11
19090763-1	2009	Applying magnetic exchange force microscopy with an Fe-coated tip, we experimentally resolve the atomic-scale antiferromagnetic structure of the Fe monolayer on W(001).	Iron	52-54	TOR signaling pathway regulator	Homo sapiens	62-65
10950940-1	2000	Hemochromatosis type 2 (HFE2) or juvenile hemochromatosis (JH) is a rare recessive disorder that causes iron overload, characterized by early onset and severe clinical course.	Iron	104-108	hemojuvelin BMP co-receptor	Homo sapiens	24-28
19090763-1	2009	Applying magnetic exchange force microscopy with an Fe-coated tip, we experimentally resolve the atomic-scale antiferromagnetic structure of the Fe monolayer on W(001).	Iron	145-147	TOR signaling pathway regulator	Homo sapiens	62-65
18832439-0	2009	Potential role of bone morphogenetic protein (BMP) signalling as a potential therapeutic target for modification of iron balance.	Iron	116-120	bone morphogenetic protein 1	Homo sapiens	18-44
10809683-6	2000	Mutants lacking both PMT1 and PMT6 are viable and show pmt1 mutant phenotypes and an additional sensitivity to the iron chelator ethylenediamine-di(o-hydroxyphenylacetic acid).	Iron	115-119	dolichyl-phosphate-mannose-protein mannosyltransferase PMT6	Saccharomyces cerevisiae S288C	30-34
10784602-0	2000	NASH: Can we iron out the pathogenesis?	Iron	13-17	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	0-4
18832439-0	2009	Potential role of bone morphogenetic protein (BMP) signalling as a potential therapeutic target for modification of iron balance.	Iron	116-120	bone morphogenetic protein 1	Homo sapiens	46-49
19093740-1	2009	Hepcidin is a key regulator of iron metabolism and a mediator of anemia in inflammation.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
10747808-0	2000	Iron-sulfur center of biotin synthase and lipoate synthase.	Iron	0-4	lipoic acid synthetase	Homo sapiens	42-58
19240805-8	2009	CONCLUSION: The up-regulation of DMT1-IRE and the increase in DMT1-IRE-mediated iron influx play a key role in L-DOPA neurotoxicity in cortical neurons.	Iron	80-84	solute carrier family 11 member 2	Homo sapiens	62-66
18835904-7	2008	For myoglobin, the resilience of the iron environment is larger than the average resilience previously determined for hydrogen sites using neutron scattering.	Iron	37-41	myoglobin	Homo sapiens	4-13
10770282-2	2000	Nramp1 regulates the microenvironment of the invading pathogen by increasing the luminal iron that participates in the Haber-Weiss reaction, producing radicals that attack the pathogen.	Iron	29-33	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
10770282-7	2000	We propose that Nramp1 activity may control its own expression via a negative autoregulatory loop that is important for iron homeostasis and maintenance of low cytoplasmic redox active iron levels in the macrophage.	Iron	120-124	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	16-22
10770282-7	2000	We propose that Nramp1 activity may control its own expression via a negative autoregulatory loop that is important for iron homeostasis and maintenance of low cytoplasmic redox active iron levels in the macrophage.	Iron	185-189	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	16-22
18930916-7	2008	Mutation of the homologous amino acid (N45I) in COT1 results in an increased ability to transport iron and decreased ability to transport cobalt.	Iron	98-102	metal cation transporter COT1	Saccharomyces cerevisiae S288C	48-52
10724176-1	2000	Myoglobin, a small globular haem protein that binds gaseous ligands such as O2, CO and NO reversibly at the haem iron, serves as a model for studying structural and dynamic aspects of protein reactions.	Iron	113-117	myoglobin	Homo sapiens	0-9
17024033-9	2000	Nramp2, also called DMT1 (divalent metal ion transporter), seems to be a major regulator of transferrin-independent, nonheme iron uptake.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	0-6
17024033-9	2000	Nramp2, also called DMT1 (divalent metal ion transporter), seems to be a major regulator of transferrin-independent, nonheme iron uptake.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	20-24
10729745-4	2000	Current data have shown that the heme center of myoglobin can initiate lipid peroxidation and renal injury without invoking release of free iron, and this process is due to redox cycling of the heme group from ferrous to ferric and to ferryl oxidation states.	Iron	140-144	myoglobin	Homo sapiens	48-57
19058322-9	2008	Thus, hepatocyte HFE is indispensable for signaling to hepcidin, presumably as a constituent of a larger iron-sensing complex.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	55-63
19058322-12	2008	In this way, iron uptake by the hepatocyte is translated into upregulation of hepcidin, reinforcing the concept that the liver is the major regulatory site for systemic iron homeostasis, and not merely an iron storage depot.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	78-86
19058322-12	2008	In this way, iron uptake by the hepatocyte is translated into upregulation of hepcidin, reinforcing the concept that the liver is the major regulatory site for systemic iron homeostasis, and not merely an iron storage depot.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	78-86
10754275-0	2000	Modifications in heme iron of free and vesicle bound cytochrome c by tert-butyl hydroperoxide: a magnetic circular dichroism and electron paramagnetic resonance investigation.	Iron	22-26	telomerase reverse transcriptase	Homo sapiens	69-73
19058322-12	2008	In this way, iron uptake by the hepatocyte is translated into upregulation of hepcidin, reinforcing the concept that the liver is the major regulatory site for systemic iron homeostasis, and not merely an iron storage depot.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	78-86
18986169-0	2008	Studies on the mechanism of catalysis of iron-sulfur cluster transfer from IscU[2Fe2S] by HscA/HscB chaperones.	Iron	41-45	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	95-99
11272558-0	2000	Electronic structure of [(CpCr)[(CO)3M]]mu-Cot (M = Cr, Fe): a theoretical study.	Iron	56-58	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	43-46
18986169-1	2008	The HscA/HscB chaperone/cochaperone system accelerates transfer of iron-sulfur clusters from the FeS-scaffold protein IscU (IscU(2)[2Fe2S], holo-IscU) to acceptor proteins in an ATP-dependent manner.	Iron	67-71	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	9-13
19159062-1	2008	Ceruloplasmin functions as a ferroxidase in iron metabolism.	Iron	44-48	ceruloplasmin	Homo sapiens	0-13
10693807-8	2000	Human Ferroportin1 is found at the basal surface of placental syncytiotrophoblasts, suggesting that it also transports iron from mother to embryo.	Iron	119-123	solute carrier family 40 member 1	Homo sapiens	6-18
10693807-9	2000	Mammalian Ferroportin1 is expressed at the basolateral surface of duodenal enterocytes and could export cellular iron into the circulation.	Iron	113-117	solute carrier family 40 member 1	Homo sapiens	10-22
19159062-3	2008	We postulated that lower circulating ceruloplasmin levels in PD would result in rapid brain iron accumulation and an earlier age of onset.	Iron	92-96	ceruloplasmin	Homo sapiens	37-50
10687957-0	2000	Ribonuclease, cell-free translation-inhibitory and superoxide radical scavenging activities of the iron-binding protein lactoferrin from bovine milk.	Iron	99-103	lactotransferrin	Bos taurus	120-131
18838961-9	2008	In conclusion, hepcidin expression appears to be appropriately responsive to iron status in cirrhosis.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	15-23
10627487-2	2000	The transport of Fe is stimulated by the presence of either apo-transferrin (apo-Tf) or ferri-transferrin (Fe-Tf) in the basal chamber with the stimulation occurring at much lower concentrations of apo-Tf than Fe-Tf.	Iron	17-19	aminopeptidase O (putative)	Homo sapiens	60-63
10627487-2	2000	The transport of Fe is stimulated by the presence of either apo-transferrin (apo-Tf) or ferri-transferrin (Fe-Tf) in the basal chamber with the stimulation occurring at much lower concentrations of apo-Tf than Fe-Tf.	Iron	17-19	aminopeptidase O (putative)	Homo sapiens	77-80
10627487-2	2000	The transport of Fe is stimulated by the presence of either apo-transferrin (apo-Tf) or ferri-transferrin (Fe-Tf) in the basal chamber with the stimulation occurring at much lower concentrations of apo-Tf than Fe-Tf.	Iron	17-19	aminopeptidase O (putative)	Homo sapiens	77-80
10627487-3	2000	To further explore the involvement of Tf in Fe transport across the basal surface, laser scanning confocal microscopy with 3-dimensional reconstruction of the confocal images was used to visualize the internalization of Texas Red-labeled apo-Tf and Bodipy-labeled Fe-Tf from the basal chamber.	Iron	44-46	aminopeptidase O (putative)	Homo sapiens	238-241
18838961-10	2008	However, there are complex alterations in DMT1 and ferroportin expression in cirrhotic liver, including decreases in ferroportin and DMT1 at the protein level that may play a role in aberrant regulation of iron metabolism in cirrhosis.	Iron	206-210	solute carrier family 11 member 2	Homo sapiens	133-137
21136813-2	2008	Ceruloplasmin (Cp) protein is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form, protecting the central nervous system (CNS) from iron deposition.	Iron	72-76	ceruloplasmin	Homo sapiens	0-13
10644516-8	2000	Iron depletion by desferrioxamine mesylate, a specific iron complexon, completely inhibited hypoxic stimulation of HO-1 but did not attenuate the effect of H(2)O(2) and CCCP on HO-1 mRNA.	Iron	0-4	heme oxygenase 1	Homo sapiens	115-119
21136813-2	2008	Ceruloplasmin (Cp) protein is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form, protecting the central nervous system (CNS) from iron deposition.	Iron	155-159	ceruloplasmin	Homo sapiens	0-13
10644516-8	2000	Iron depletion by desferrioxamine mesylate, a specific iron complexon, completely inhibited hypoxic stimulation of HO-1 but did not attenuate the effect of H(2)O(2) and CCCP on HO-1 mRNA.	Iron	55-59	heme oxygenase 1	Homo sapiens	115-119
19036966-0	2008	Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage.	Iron	48-52	ceruloplasmin	Mus musculus	0-13
19036966-4	2008	We show that ceruloplasmin (Cp), a ferroxidase that oxidizes toxic ferrous iron, is important for this process.	Iron	75-79	ceruloplasmin	Mus musculus	13-26
10617129-7	2000	Also, the microtubule-associated protein tau, as an in vitro model for proteins relevant to AD pathology, was found capable of adventitious binding of copper and iron in a redox-competent manner.	Iron	162-166	microtubule associated protein tau	Homo sapiens	10-44
18689548-5	2008	Serum hepcidin appropriately correlated with serum ferritin (r = 0.63), reflecting the regulation of both proteins by iron stores.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	6-14
10905536-0	2000	Another jigsaw piece towards solving the iron metabolism puzzle: the cloning of the iron exporter, ferroportin1.	Iron	41-45	solute carrier family 40 member 1	Homo sapiens	99-111
18689548-6	2008	Healthy volunteers showed a diurnal increase of serum hepcidin at noon and 8 pm compared with 8 am, and a transient rise of serum hepcidin in response to iron ingestion.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	130-138
10905536-0	2000	Another jigsaw piece towards solving the iron metabolism puzzle: the cloning of the iron exporter, ferroportin1.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	99-111
18689548-7	2008	Expected alterations in hepcidin levels were observed in a variety of clinical conditions associated with iron disturbances.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	24-32
10600893-7	1999	Our results suggest that pulmonary lactoferrin and ferritin protect animals against oxidative stress, most likely via their capacity to sequester iron, and that alveolar macrophages are the key participants in iron detoxification in the lower respiratory tract.	Iron	146-150	lactotransferrin	Mus musculus	35-46
18689548-8	2008	Serum hepcidin concentrations were undetectable or low in patients with iron deficiency anemia (ferritin &lt; 10 ng/mL), iron-depleted HFE hemochromatosis, and juvenile hemochromatosis.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	6-14
18528644-10	2008	Heme oxygenase 1 expression increased and DMT1 expression decreased with higher heme Fe concentrations in the media.	Iron	85-87	heme oxygenase 1	Homo sapiens	0-16
10581397-1	1999	Heme oxygenase-1 (HO-1) is an inducible enzyme involved in heme catabolism, tissue iron homeostasis and the cellular response to oxidative stress.	Iron	83-87	heme oxygenase 1	Homo sapiens	0-16
10581397-1	1999	Heme oxygenase-1 (HO-1) is an inducible enzyme involved in heme catabolism, tissue iron homeostasis and the cellular response to oxidative stress.	Iron	83-87	heme oxygenase 1	Homo sapiens	18-22
10581397-2	1999	Elevated HO-1 expression in astrocytes has been observed in association with abnormal iron deposition and increased oxidative stress in Parkinson"s disease (PD).	Iron	86-90	heme oxygenase 1	Homo sapiens	9-13
10581397-13	1999	HO-1 and its metabolites could then contribute to the oxidative stress and iron deposition associated with PD.	Iron	75-79	heme oxygenase 1	Homo sapiens	0-4
18528644-10	2008	Heme oxygenase 1 expression increased and DMT1 expression decreased with higher heme Fe concentrations in the media.	Iron	85-87	doublesex and mab-3 related transcription factor 1	Homo sapiens	42-46
18991287-2	2008	Nramp1-functionality is associated with alterations of cellular iron homeostasis and a sustained pro-inflammatory immune response, including the formation of the antimicrobial effector molecule NO.	Iron	64-68	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
10598021-8	1999	These results suggest that the inhibition of LLO-induced hemolysis by bovine LFR is influenced by pH and iron ions, both of which may lead to conformational changes of LFR.	Iron	105-109	lactotransferrin	Bos taurus	77-80
10598021-8	1999	These results suggest that the inhibition of LLO-induced hemolysis by bovine LFR is influenced by pH and iron ions, both of which may lead to conformational changes of LFR.	Iron	105-109	lactotransferrin	Bos taurus	168-171
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	31-35	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	92-98
10522550-8	1999	However, studies with blocking antibodies, observations in rodents with disorders of iron metabolism, and studies in tissue culture cells suggest that the DCT-1 pathway is dominant in embryonic cells and is involved with cellular uptake of ferrous iron, whereas the mobilferrin-integrin pathway facilitates absorption of dietary inorganic ferric iron.	Iron	248-252	solute carrier family 11 member 2	Homo sapiens	155-160
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	31-35	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	205-211
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	243-247	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	92-98
18991287-7	2008	Oppositely, supplementation of iron to RAW-21 cells further increased IL-10 formation.Thus, Nramp1 mediates effective host defence in part via suppression of excessive IL-10 production which may relate to Nramp1-mediated reduction of cellular iron pools, thus strengthening antimicrobial effector mechanisms.	Iron	243-247	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	205-211
18671304-3	2008	Hepcidin plays a pivotal role as a negative regulator of iron absorption.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
18804889-0	2008	Hepcidin in the management of patients with mild non-hemochromatotic iron overload: Fact or fiction?	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
18619468-0	2008	The PMS2 subunit of human MutLalpha contains a metal ion binding domain of the iron-dependent repressor protein family.	Iron	79-83	PMS1 homolog 2, mismatch repair system component	Homo sapiens	4-8
18576916-1	2008	Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin, has been recognized as playing a crucial role in cellular defense against stressful conditions, not only related to heme release.	Iron	63-67	heme oxygenase 1	Homo sapiens	0-16
18637800-5	2008	New forms have been recognized as being linked to the deficient function of mitochondrial proteins involved in iron-sulphur cluster biogenesis, such as ABCB7 and GLRX5, which are extremely rare but represent important biological models.	Iron	111-115	ATP binding cassette subfamily B member 7	Homo sapiens	152-157
18637800-5	2008	New forms have been recognized as being linked to the deficient function of mitochondrial proteins involved in iron-sulphur cluster biogenesis, such as ABCB7 and GLRX5, which are extremely rare but represent important biological models.	Iron	111-115	glutaredoxin 5	Homo sapiens	162-167
18641032-1	2008	The relationship between serum hepcidin, a key regulator of body iron homeostasis, and erythropoiesis was investigated before and after stem cell transplantation in 31 patients with hematopoietic malignancies.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	31-39
19045028-4	2008	The implied spin magnetic moments of these systems suggest that [Fe(COT)], [Fe(2)(COT)], and [Co(COT)] retain the magnetic moments of the Fe atom, the Fe(2) dimer, and the Co atom, respectively.	Iron	65-67	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	68-71
10527125-12	1999	Low iron intake, required for the production of pale meat, besides anemia causes metabolic and endocrine adaptations, such as enhanced insulin-dependent glucose utilization and appears to reduce IGF-I responses to GH.	Iron	4-8	insulin	Bos taurus	135-142
18717590-2	2008	EPR, Mossbauer spectroscopy, and electron microscopy were used to characterize the Fe that accumulates in Yah1p-depleted isolated intact mitochondria.	Iron	83-85	adrenodoxin	Saccharomyces cerevisiae S288C	106-111
10517538-4	1999	UVA radiation also leads to an increase in labile iron pools (either directly or via HO-1) and eventual increases in ferritin levels.	Iron	50-54	heme oxygenase 1	Homo sapiens	85-89
10582331-5	1999	isolated DMT1 through an expression cloning strategy looking for mRNAs that stimulated iron uptake by Xenopus oocytes.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	9-13
10582331-6	1999	Taken together, these data indicate that the twelve transmembrane domain protein DMT1 transfers iron across the apical surface of intestinal cells and out of transferrin cycle endosomes.	Iron	96-100	solute carrier family 11 member 2	Homo sapiens	81-85
10582331-7	1999	Human DMT1 may be a good target for pharmacological intervention in patients with iron overload disorders attributable to increased iron absorption.	Iron	82-86	solute carrier family 11 member 2	Homo sapiens	6-10
10546545-4	1999	The purpose of this study was to compare these species in terms of (1) rates of accumulation in photodynamically treated liposomal membranes; (2) susceptibility to iron-mediated 1 e- reduction that triggers chain peroxidative damage; (3) susceptibility to selenoperoxidase (phospholipid hydroperoxide glutathione peroxidase [PHGPX])-mediated 2 e- reduction that protects against such damage and (4) relative toxicity to mammalian cells.	Iron	164-168	glutathione peroxidase 4	Homo sapiens	274-323
10546545-4	1999	The purpose of this study was to compare these species in terms of (1) rates of accumulation in photodynamically treated liposomal membranes; (2) susceptibility to iron-mediated 1 e- reduction that triggers chain peroxidative damage; (3) susceptibility to selenoperoxidase (phospholipid hydroperoxide glutathione peroxidase [PHGPX])-mediated 2 e- reduction that protects against such damage and (4) relative toxicity to mammalian cells.	Iron	164-168	glutathione peroxidase 4	Homo sapiens	325-330
18717590-5	2008	The absence of strong EPR signals from Fe/S clusters when Yah1p was depleted confirms that Yah1p is required in Fe/S cluster assembly.	Iron	112-114	adrenodoxin	Saccharomyces cerevisiae S288C	58-63
18717590-5	2008	The absence of strong EPR signals from Fe/S clusters when Yah1p was depleted confirms that Yah1p is required in Fe/S cluster assembly.	Iron	112-114	adrenodoxin	Saccharomyces cerevisiae S288C	91-96
18717590-6	2008	Yah1p-depleted mitochondria, grown with O 2 bubbling through the media, accumulated excess Fe (up to 10 mM) that was present as 2-4 nm diameter ferric nanoparticles, similar to those observed in mitochondria from yfh1Delta cells.	Iron	91-93	adrenodoxin	Saccharomyces cerevisiae S288C	0-5
18717590-10	2008	This suggests that the O 2 used during growth of Gal- YAH1 cells is responsible, either directly or indirectly, for Fe accumulation and for oxidizing Fe (2+) --&gt; Fe (3+) prior to aggregation.	Iron	116-118	adrenodoxin	Saccharomyces cerevisiae S288C	54-58
10480920-2	1999	Ceruloplasmin (CP) is a major multicopper-containing plasma protein that is not only involved in iron metabolism through its ferroxidase activity but also functions as an antioxidant.	Iron	97-101	ceruloplasmin	Homo sapiens	0-13
18725572-0	2008	GASing up iron delivery via STAT5.	Iron	10-14	signal transducer and activator of transcription 5A	Homo sapiens	28-33
10480920-2	1999	Ceruloplasmin (CP) is a major multicopper-containing plasma protein that is not only involved in iron metabolism through its ferroxidase activity but also functions as an antioxidant.	Iron	97-101	ceruloplasmin	Homo sapiens	15-17
18557745-11	2008	During depletion, therefore, hepcidin levels are decreased, which may exacerbate intestinal iron absorption.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	29-37
10485908-0	1999	Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.	Iron	81-85	ceruloplasmin	Mus musculus	55-68
10485908-9	1999	Our findings reveal an essential physiologic role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores.	Iron	95-99	ceruloplasmin	Mus musculus	54-67
10485908-9	1999	Our findings reveal an essential physiologic role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores.	Iron	135-139	ceruloplasmin	Mus musculus	54-67
10520410-6	1999	Recent data give informations about new proteins involved in iron metabolism: HFE whose gene is mutated in genetic hemochromatosis, ceruloplasmin which permits cellular iron egress and frataxin which is implicated in the exit of iron from mitochondria.	Iron	61-65	ceruloplasmin	Homo sapiens	132-145
10520410-6	1999	Recent data give informations about new proteins involved in iron metabolism: HFE whose gene is mutated in genetic hemochromatosis, ceruloplasmin which permits cellular iron egress and frataxin which is implicated in the exit of iron from mitochondria.	Iron	169-173	ceruloplasmin	Homo sapiens	132-145
18586377-10	2008	CONCLUSION: The expression of TfR1, ferritin and FP1 in the human term placenta tissues showed different trend of change with different maternal iron status.	Iron	145-149	solute carrier family 40 member 1	Homo sapiens	49-52
18586377-13	2008	In addition to FP1, other proteins may be involved in the placental iron efflux either directly or indirectly.	Iron	68-72	solute carrier family 40 member 1	Homo sapiens	15-18
10423181-0	1999	Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.	Iron	83-87	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	29-35
18791966-3	2008	Hepcidin, which seems to be the master protein for regulation of intestinal iron absorption, is known for a short time.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
10410998-6	1999	These results are consistent with the hypothesis that Nramp1 functions to transport Fe into the bacterium-containing phagosome where it serves as a catalyst for the Haber-Weiss reaction, which accounts for the increased capacity of these cells to limit mycobacterial growth.	Iron	84-86	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	54-60
18791966-4	2008	The expression of hepcidin is not only influenced by iron levels but also by mediators of inflammation and growth factors of erythropoiesis.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	18-26
18791966-5	2008	Hence hepcidin plays also a crucial role in the development of anemia of chronic disease and iron overload due to ineffective erythropoiesis.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	6-14
18561026-3	2008	Rises in plasma AST were preceded by a decline in serum iron levels.	Iron	56-60	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	16-19
11671034-0	1999	Theoretical Model Studies of the Iron Dimer Complex of MMO and RNR.	Iron	33-37	nuclear receptor subfamily 2 group E member 3	Homo sapiens	63-66
11671034-4	1999	To obtain the very short Fe-Fe distances recently measured by EXAFS, it is suggested that both compound Q of MMO and compound X of RNR have two bridging carboxylates like the reduced diferrous complex but unlike the diferric complex.	Iron	25-27	nuclear receptor subfamily 2 group E member 3	Homo sapiens	131-134
11671034-4	1999	To obtain the very short Fe-Fe distances recently measured by EXAFS, it is suggested that both compound Q of MMO and compound X of RNR have two bridging carboxylates like the reduced diferrous complex but unlike the diferric complex.	Iron	28-30	nuclear receptor subfamily 2 group E member 3	Homo sapiens	131-134
18447830-0	2008	Identification of an iron-hepcidin complex.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	26-34
18447830-4	2008	From urine-purified native hepcidin, we recently demonstrated that a proportion of the purified hepcidin had formed iron-hepcidin complexes.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	96-104
10229861-0	1999	Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression.	Iron	61-65	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	37-43
18447830-4	2008	From urine-purified native hepcidin, we recently demonstrated that a proportion of the purified hepcidin had formed iron-hepcidin complexes.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	96-104
18979637-1	2008	Lactoferrin (LF) is an iron-binding protein present in several secreted substances, such as milk, and has broad antimicrobial and physiological properties.	Iron	23-27	lactotransferrin	Bos taurus	0-11
10196363-3	1999	This gene, ABC7, is an ortholog of the yeast ATM1 gene whose product localizes to the mitochondrial inner membrane and is involved in iron homeostasis.	Iron	134-138	ATP binding cassette subfamily B member 7	Homo sapiens	11-15
18979637-1	2008	Lactoferrin (LF) is an iron-binding protein present in several secreted substances, such as milk, and has broad antimicrobial and physiological properties.	Iron	23-27	lactotransferrin	Bos taurus	13-15
18979640-1	2008	In the past few years the role of hepcidin metabolism disturbances, a recently described key regulator of iron metabolism, has been raised in patients with chronic liver diseases.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	34-42
10101013-0	1999	Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells.	Iron	0-4	heme oxygenase 1	Homo sapiens	41-57
18557934-1	2008	Hepcidin is a liver produced cysteine-rich peptide hormone that acts as the central regulator of body iron metabolism.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	0-8
10101013-8	1999	We also found that HO-1 expression depended on chelatable iron.	Iron	58-62	heme oxygenase 1	Homo sapiens	19-23
10101013-9	1999	The iron chelator desferrioxamine not only inhibited the iron- dependent potentiation of HO-1 in response to hyperoxia but also inhibited both hyperoxia and basal expression.	Iron	4-8	heme oxygenase 1	Homo sapiens	89-93
10101013-9	1999	The iron chelator desferrioxamine not only inhibited the iron- dependent potentiation of HO-1 in response to hyperoxia but also inhibited both hyperoxia and basal expression.	Iron	57-61	heme oxygenase 1	Homo sapiens	89-93
18557934-4	2008	Hepcidin binds to ferroportin, inducing its internalization and degradation, thus regulating the export of iron from cells to plasma.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	0-8
10085004-1	1999	Lactoferrin (Lf), an iron-sequestering glycoprotein, predominates in mucosal secretions, where the level of free extracellular iron (10(-18) M) is not sufficient for bacterial growth.	Iron	21-25	HLF transcription factor, PAR bZIP family member	Homo sapiens	13-15
18616471-9	2008	Our results suggest an important involvement of the essential thioredoxin-thioredoxin reductase system in cancer cell cytotoxicity by organo-sulfane sulfur compounds and highlight the correlation between apoptosis induced by these compounds and the damage to the mitochondrial enzymes involved in the repair of the Fe-S cluster and in the detoxification system.	Iron	315-319	thioredoxin	Homo sapiens	62-73
10085004-3	1999	In this study we were able to show that Streptococcus pneumoniae specifically recognizes and binds the iron carrier protein human Lf (hLf).	Iron	103-107	HLF transcription factor, PAR bZIP family member	Homo sapiens	130-132
10085004-3	1999	In this study we were able to show that Streptococcus pneumoniae specifically recognizes and binds the iron carrier protein human Lf (hLf).	Iron	103-107	HLF transcription factor, PAR bZIP family member	Homo sapiens	134-137
10085004-8	1999	S. pneumoniae may use the hLf-PspA interaction to overcome the iron limitation at mucosal surfaces, and this might represent a potential virulence mechanism.	Iron	63-67	HLF transcription factor, PAR bZIP family member	Homo sapiens	26-29
18616471-9	2008	Our results suggest an important involvement of the essential thioredoxin-thioredoxin reductase system in cancer cell cytotoxicity by organo-sulfane sulfur compounds and highlight the correlation between apoptosis induced by these compounds and the damage to the mitochondrial enzymes involved in the repair of the Fe-S cluster and in the detoxification system.	Iron	315-319	thioredoxin	Homo sapiens	74-85
18496733-6	2008	Antioxidants, calcium chelators, iron chelators, and PLA(2) inhibitors offered attenuation of the vitamin C-induced activation of both PLA(2) and PLD in the cells.	Iron	33-37	LOC104974671	Bos taurus	135-141
10233755-7	1999	Here we showed that Nramp1 directs iron transport within the macrophage.	Iron	35-39	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	20-26
10233755-10	1999	Expression of the Nramp1 polypeptide correlates with lower cellular iron loads and a reduced chelatable iron pool following challenge with iron: nitrilotriacetate.	Iron	68-72	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	18-24
10233755-10	1999	Expression of the Nramp1 polypeptide correlates with lower cellular iron loads and a reduced chelatable iron pool following challenge with iron: nitrilotriacetate.	Iron	104-108	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	18-24
10233755-10	1999	Expression of the Nramp1 polypeptide correlates with lower cellular iron loads and a reduced chelatable iron pool following challenge with iron: nitrilotriacetate.	Iron	104-108	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	18-24
10233755-14	1999	These data suggest Nramp1, in resting macrophage cells, mobilizes iron, from an intracellular vesicle, which is destined for cell secretion.	Iron	66-70	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	19-25
10233755-15	1999	We propose that under these conditions Nramp1 plays a role in a salvage pathway of iron recycling.	Iron	83-87	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	39-45
18694584-0	2008	Adsorptive selenite removal from water using iron-coated GAC adsorbents.	Iron	45-49	glutaminase	Homo sapiens	57-60
18694584-1	2008	Removal of selenite from aqueous phase using iron-coated granular activated carbons (GAC) was investigated in this study.	Iron	45-49	glutaminase	Homo sapiens	85-88
10847721-0	1999	[c-Myc: an iron oncogene].	Iron	11-15	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	1-6
18694584-2	2008	Five different types of GAC were used for iron coating by oxidizing ferrous chloride with sodium hypochlorite and the iron-coated GAC (Fe-GAC) were tested for selenite removal.	Iron	42-46	glutaminase	Homo sapiens	24-27
18694584-2	2008	Five different types of GAC were used for iron coating by oxidizing ferrous chloride with sodium hypochlorite and the iron-coated GAC (Fe-GAC) were tested for selenite removal.	Iron	118-122	glutaminase	Homo sapiens	130-133
18694584-2	2008	Five different types of GAC were used for iron coating by oxidizing ferrous chloride with sodium hypochlorite and the iron-coated GAC (Fe-GAC) were tested for selenite removal.	Iron	118-122	glutaminase	Homo sapiens	135-141
18694584-4	2008	The Darco 12x20 GAC was shown to be the most effective adsorbent among the five tested GACs after iron coating.	Iron	98-102	glutaminase	Homo sapiens	16-19
9931300-7	1999	The marked inhibitory effect of Tb(III) on the kinetics of iron incorporation confirms that carboxylates provide the iron ligands in L. innocua apoferritin.	Iron	117-121	ferritin heavy chain 1	Homo sapiens	144-155
9931300-8	1999	Iron uptake followed in steady-state fluorescence experiments allows one to distinguish Fe(II) binding and oxidation from the subsequent movement of Fe(III) into the apoferritin cavity as in mammalian ferritins despite the different localization of the tryptophan residues.	Iron	0-4	ferritin heavy chain 1	Homo sapiens	166-177
18694584-5	2008	Among the different concentrations used for iron coating, the Darco 12x20 GAC coated with 0.1M ferrous chloride achieved the highest selenite removal (97.3%).	Iron	44-48	glutaminase	Homo sapiens	74-77
9935166-6	1999	Furthermore, incubation with cobalt chloride or with an iron chelator also resulted in elevated uPAR expression, while presence of 30% carbon monoxide in the hypoxic atmosphere reduced the hypoxia-mediated uPAR mRNA upregulation.	Iron	56-60	plasminogen activator, urokinase receptor	Homo sapiens	96-100
9935166-6	1999	Furthermore, incubation with cobalt chloride or with an iron chelator also resulted in elevated uPAR expression, while presence of 30% carbon monoxide in the hypoxic atmosphere reduced the hypoxia-mediated uPAR mRNA upregulation.	Iron	56-60	plasminogen activator, urokinase receptor	Homo sapiens	206-210
18477464-1	2008	The iron atom in the nonheme iron monooxygenase phenylalanine hydroxylase is bound on one face by His285, His290, and Glu330.	Iron	4-8	phenylalanine hydroxylase	Rattus norvegicus	48-73
10391079-10	1999	Systemic iron deposition and tissue damage were considered as caused by deficiency of function of ceruloplasmin as ferroxidase.	Iron	9-13	ceruloplasmin	Homo sapiens	98-111
18485885-4	2008	Co-incubation with dapsone resulted in reduced substrate proton to heme-iron distances for all enzymes, providing at least a partial mechanism for the activation of CYP2C9 variants by dapsone.	Iron	72-76	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	165-171
18628991-1	2008	Assays for the detection of the iron regulatory hormone hepcidin in plasma or urine have not yet been widely available, whereas quantitative comparisons between hepcidin levels in these different matrices were thus far even impossible due to technical restrictions.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	56-64
9873059-0	1999	Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism.	Iron	55-59	ceruloplasmin	Homo sapiens	0-25
18628991-4	2008	The assay improvements were clinically evaluated using samples from various patients groups and its relevance was further underscored by the significant correlation of serum hepcidin levels with serum iron indices in healthy individuals.	Iron	201-205	hepcidin antimicrobial peptide	Homo sapiens	174-182
10529542-10	1999	Following the intravenous administration of commercially available fresh-frozen human plasma (FFP) containing ceruloplasmin, the serum iron content increased for several hours due to ferroxidase activity of ceruloplasmin.	Iron	135-139	ceruloplasmin	Homo sapiens	110-123
18430498-3	2008	Increased duodenal iron absorption and enhanced macrophagic iron recycling, both due to an impairment of hepcidin synthesis, account for the development of cellular excess in types 1, 2, 3, and 4B hemochromatosis whereas decreased cellular iron egress is involved in the main form of type 4A) hemochromatosis and in aceruloplasminemia.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	105-113
10529542-10	1999	Following the intravenous administration of commercially available fresh-frozen human plasma (FFP) containing ceruloplasmin, the serum iron content increased for several hours due to ferroxidase activity of ceruloplasmin.	Iron	135-139	ceruloplasmin	Homo sapiens	207-220
9915882-3	1999	Thus, we examined whether the expression of the HFE and Nramp2 genes are regulated by iron status in the human intestinal cell line Caco-2.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	56-62
9915882-4	1999	HFE mRNA and HFE protein were increased and Nramp2 mRNA was decreased by increasing cellular iron status in Caco-2 cells.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	44-50
9915882-8	1999	This reciprocal modification of the HFE and Nramp2 gene expression during both iron treatment and cell differentiation in Caco-2 cells is consistent with an opposing role for these proteins in homeostatic regulation of human intestinal iron absorption.	Iron	79-83	solute carrier family 11 member 2	Homo sapiens	44-50
9915882-8	1999	This reciprocal modification of the HFE and Nramp2 gene expression during both iron treatment and cell differentiation in Caco-2 cells is consistent with an opposing role for these proteins in homeostatic regulation of human intestinal iron absorption.	Iron	236-240	solute carrier family 11 member 2	Homo sapiens	44-50
18430498-3	2008	Increased duodenal iron absorption and enhanced macrophagic iron recycling, both due to an impairment of hepcidin synthesis, account for the development of cellular excess in types 1, 2, 3, and 4B hemochromatosis whereas decreased cellular iron egress is involved in the main form of type 4A) hemochromatosis and in aceruloplasminemia.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	105-113
18590684-1	2008	Hepcidin, the systemic regulator of iron homeostasis is activated by proteins responsible for hereditary hemochromatosis, bone morphogenetic proteins (BMPs), and inflammatory cytokines.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
9828118-1	1998	Lactoferrin is an iron-binding glycoprotein present in high concentrations in milk and exocrine fluids such as bile and tears.	Iron	18-22	lactotransferrin	Mus musculus	0-11
9726978-1	1998	The high affinity uptake systems for iron and copper ions in Saccharomyces cerevisiae involve metal-specific permeases and two known cell surface Cu(II) and Fe(III) metalloreductases, Fre1 and Fre2.	Iron	37-41	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	193-197
9726978-4	1998	Four of the homologs (FRE3-FRE6) are specifically iron-regulated through the Aft1 transcription factor.	Iron	50-54	ferric-chelate reductase	Saccharomyces cerevisiae S288C	22-31
9726978-6	1998	Expression of FRE3-FRE6 is elevated in AFT1-1 cells and attenuated in aft1 null cells, showing that iron modulation occurs through the Aft1 transcriptional activator.	Iron	100-104	ferric-chelate reductase	Saccharomyces cerevisiae S288C	14-18
10066144-3	1998	The iron-deficient, hypoxic group had lower heart iron (p = 0.03) but higher myoglobin concentration (p &lt; 0.0001) when compared with the iron-sufficient, normoxic group.	Iron	4-8	myoglobin	Cavia porcellus	77-86
10066144-4	1998	The percentage of iron incorporated into myoglobin was higher than control in the iron-deficient, hypoxic group (23.2+/-7.2% vs. 5.2+/-0.8%; p &lt; 0.001) and increased as total heart iron decreased (r = 0.97; p &lt; 0.001).	Iron	18-22	myoglobin	Cavia porcellus	41-50
10066144-4	1998	The percentage of iron incorporated into myoglobin was higher than control in the iron-deficient, hypoxic group (23.2+/-7.2% vs. 5.2+/-0.8%; p &lt; 0.001) and increased as total heart iron decreased (r = 0.97; p &lt; 0.001).	Iron	82-86	myoglobin	Cavia porcellus	41-50
10066144-4	1998	The percentage of iron incorporated into myoglobin was higher than control in the iron-deficient, hypoxic group (23.2+/-7.2% vs. 5.2+/-0.8%; p &lt; 0.001) and increased as total heart iron decreased (r = 0.97; p &lt; 0.001).	Iron	82-86	myoglobin	Cavia porcellus	41-50
9724638-6	1998	The iron-induced arrest is bypassed by overexpression of a mutant G1 cyclin, cln3-2, and expression of the G1-specific cyclins Cln1 and Cln2 is reduced when yeast are exposed to increasing amounts of iron, which may account for the arrest.	Iron	4-8	cyclin CLN1	Saccharomyces cerevisiae S288C	127-131
9724638-6	1998	The iron-induced arrest is bypassed by overexpression of a mutant G1 cyclin, cln3-2, and expression of the G1-specific cyclins Cln1 and Cln2 is reduced when yeast are exposed to increasing amounts of iron, which may account for the arrest.	Iron	200-204	cyclin CLN1	Saccharomyces cerevisiae S288C	127-131
9727700-3	1998	Taken together with earlier studies that characterized ceruloplasmin as a ferroxidase and recent work indicating an essential role for a homologous multicopper oxidase in iron metabolism in Saccharomyces cerevisiae, these findings reveal an essential role for ceruloplasmin in human iron metabolism.	Iron	171-175	ceruloplasmin	Homo sapiens	55-68
9727700-3	1998	Taken together with earlier studies that characterized ceruloplasmin as a ferroxidase and recent work indicating an essential role for a homologous multicopper oxidase in iron metabolism in Saccharomyces cerevisiae, these findings reveal an essential role for ceruloplasmin in human iron metabolism.	Iron	283-287	ceruloplasmin	Homo sapiens	55-68
9727700-4	1998	The presence of neurologic symptoms in patients with aceruloplasminemia is unique among the characterized disorders of iron metabolism, and recent findings indicate that astrocyte-specific ceruloplasmin gene expression is critical for iron metabolism and neuronal survival in the retina and basal ganglia.	Iron	119-123	ceruloplasmin	Homo sapiens	54-67
9733525-8	1998	FRE2 and double transformants were more tolerant to Fe deficiency in hydroponic culture, as shown by higher chlorophyll and Fe concentrations in younger leaves, whereas FRE1 transformants did not differ from the controls.	Iron	52-54	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-4
9733525-9	1998	Overall, the beneficial effects of FRE2 were consistent, suggesting that FRE2 may be used to improve Fe efficiency in crop plants.	Iron	101-103	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	35-39
9733525-9	1998	Overall, the beneficial effects of FRE2 were consistent, suggesting that FRE2 may be used to improve Fe efficiency in crop plants.	Iron	101-103	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	73-77
18599958-1	2008	When maintained on a folate-deficient, iron-rich diet, transgenic mice lacking in apolipoprotein E (ApoE-/- mice) demonstrate impaired activity of glutathione S-transferase (GST), resulting in increased oxidative species within brain tissue despite abnormally high levels of glutathione.	Iron	39-43	hematopoietic prostaglandin D synthase	Mus musculus	147-172
9800317-8	1998	Although, moderate iron restriction to young male rats was associated with marked alterations in iron status and serum enzymes, the activities of tricarboxylic acid cycle enzymes including malic dehydrogenase, fumarase, and isocitric dehydrogenase as well as cytochrome oxidase in liver remained largely unaffected.	Iron	19-23	fumarate hydratase	Rattus norvegicus	210-218
9725962-4	1998	Animals with beta(2)-microglobulin deficiency develop iron overload, indicating this protein to be involved in the regulation of iron metabolism.	Iron	54-58	beta-2-microglobulin	Homo sapiens	13-34
9725962-4	1998	Animals with beta(2)-microglobulin deficiency develop iron overload, indicating this protein to be involved in the regulation of iron metabolism.	Iron	129-133	beta-2-microglobulin	Homo sapiens	13-34
18462824-6	2008	mRNA and urinary hepcidin levels normalized for the amount of iron overload showed a significantly lower ratio than in controls, although not as low as in hemochromatosis or beta-thalassemia.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	17-25
9729418-1	1998	New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism.	Iron	153-157	solute carrier family 11 member 2	Homo sapiens	109-113
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	59-63	intelectin 1	Homo sapiens	38-41
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	59-63	solute carrier family 11 member 2	Homo sapiens	51-55
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	84-88	intelectin 1	Homo sapiens	38-41
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	84-88	solute carrier family 11 member 2	Homo sapiens	51-55
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	84-88	ceruloplasmin	Homo sapiens	78-80
18462824-9	2008	The relatively elevated urinary hepcidin can explain the iron phenotype in DHIO (more macrophage iron retention and low/normal transferrin saturation).	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	32-40
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	84-88	intelectin 1	Homo sapiens	38-41
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	84-88	solute carrier family 11 member 2	Homo sapiens	51-55
18491043-0	2008	Molecular understanding of copper and iron interaction with alpha-synuclein by fluorescence analysis.	Iron	38-42	synuclein alpha	Homo sapiens	60-75
9729418-3	1998	Further studies on the involvement of LfR, MTf and DCT1 in iron uptake by and CP in iron egress from different types of brain cells as well as control mechanisms of expression of these proteins in the brain are critical for elucidating the causes of excessive accumulation of iron in the brain and neuronal death in neurodegenerative diseases.	Iron	84-88	ceruloplasmin	Homo sapiens	78-80
18491043-3	2008	Redox-active metal ions such as iron (Fe) and copper (Cu) are known to enhance alpha-synuclein fibrillogenesis.	Iron	32-36	synuclein alpha	Homo sapiens	79-94
9767436-0	1998	Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication: a role for intracellular iron.	Iron	111-115	interferon gamma	Rattus norvegicus	0-16
18491043-3	2008	Redox-active metal ions such as iron (Fe) and copper (Cu) are known to enhance alpha-synuclein fibrillogenesis.	Iron	38-40	synuclein alpha	Homo sapiens	79-94
9767436-7	1998	Experiments using Fe2+ salt, carrier and chelator indicate that intracellular T. gondii replication is iron dependent, suggesting that IFN-gamma-treated enterocytes inhibit T. gondii replication by limiting the availability of intracellular iron to the parasite.	Iron	103-107	interferon gamma	Rattus norvegicus	135-144
9767436-7	1998	Experiments using Fe2+ salt, carrier and chelator indicate that intracellular T. gondii replication is iron dependent, suggesting that IFN-gamma-treated enterocytes inhibit T. gondii replication by limiting the availability of intracellular iron to the parasite.	Iron	241-245	interferon gamma	Rattus norvegicus	135-144
18491043-4	2008	In the present investigation, we analyzed the binding efficiency of Cu and Fe to alpha-synuclein by fluorescence studies.	Iron	75-77	synuclein alpha	Homo sapiens	81-96
9701579-3	1998	ATX1-deficient yeast (atx1) displayed a loss of high-affinity iron uptake.	Iron	62-66	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	0-4
18491043-5	2008	It is interesting to note that Cu and Fe showed differential binding pattern toward alpha-synuclein (wild type and A30P, A53T, and E46K mutant forms) as revealed by intrinsic tyrosine fluorescence, thioflavin-T fluorescence, 1-anilino-8-naphthalenesulfonate-binding studies, and scatchard plot analysis.	Iron	38-40	synuclein alpha	Homo sapiens	84-99
9701579-3	1998	ATX1-deficient yeast (atx1) displayed a loss of high-affinity iron uptake.	Iron	62-66	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	22-26
9701579-4	1998	Expression of CCH in the atx1 strain restored high-affinity iron uptake, demonstrating that CCH is a functional homolog of ATX1.	Iron	60-64	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	25-29
18445598-3	2008	Hepcidin is a central iron regulatory hormone predominantly secreted from hepatocytes.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
9701579-4	1998	Expression of CCH in the atx1 strain restored high-affinity iron uptake, demonstrating that CCH is a functional homolog of ATX1.	Iron	60-64	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	123-127
9595272-3	1998	Instead, metals oxidize the monoamines either directly (manganese, copper) or by oxygen free radical formation (iron), the oxidation products bind covalently to SBP and the conjugates are able to undergo redox cycling.	Iron	112-116	spermine binding protein	Rattus norvegicus	161-164
18326822-2	2008	Recent in vivo studies have shown that hepcidin is down-regulated by erythropoiesis, anemia, and hypoxia, which meets the need of iron input for erythrocyte production.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	39-47
9657901-4	1998	The objectives of the present study were to determine: (1) the effects of ascorbic acid and ferric ammonium citrate on iron uptake by canine lens epithelial cells from iron bound to transferrin and from ferric chloride and (2) the incorporation of this element into ferritin.	Iron	119-123	inhibitor of carbonic anhydrase	Canis lupus familiaris	182-193
18508159-0	2008	Influence of Na2S on the degradation kinetics of CCl4 in the presence of very pure iron.	Iron	83-87	C-C motif chemokine ligand 4	Homo sapiens	49-53
9614211-3	1998	The uptake of acetylated low density lipoprotein and the levels of MSR-I mRNA were inhibited by treatment with the oxygen radical scavengers 2,2,6, 6-tetramethylpiperidine-N-oxyl, dimethylthiourea or sodium benzoate, or the iron chelator deferoxamine.	Iron	224-228	progestin and adipoQ receptor family member 7	Homo sapiens	67-70
9614211-5	1998	These results indicate that hydroxyl radicals produced from superoxide anions and hydrogen peroxide in the presence of free iron, contribute to an increased MSR activity by stabilizing MSR-I mRNA.	Iron	124-128	progestin and adipoQ receptor family member 7	Homo sapiens	157-160
9614211-5	1998	These results indicate that hydroxyl radicals produced from superoxide anions and hydrogen peroxide in the presence of free iron, contribute to an increased MSR activity by stabilizing MSR-I mRNA.	Iron	124-128	progestin and adipoQ receptor family member 7	Homo sapiens	185-188
18508159-1	2008	This paper presents the results of kinetic studies to investigate the effect of FeS film formation on the degradation rate of CCl(4) by 99.99% pure metallic iron.	Iron	80-83	C-C motif chemokine ligand 4	Homo sapiens	126-132
18508159-1	2008	This paper presents the results of kinetic studies to investigate the effect of FeS film formation on the degradation rate of CCl(4) by 99.99% pure metallic iron.	Iron	157-161	C-C motif chemokine ligand 4	Homo sapiens	126-132
18508159-9	2008	It has been proposed that CCl(4) is reduced to HCCl(3) by metallic iron by electron transfer.	Iron	67-71	C-C motif chemokine ligand 4	Homo sapiens	26-32
18508159-10	2008	The FeS film is substantially less conducting than the bulk iron metal or non-stoichiometric magnetite and from the results of this study, greatly decreases the rate of CCl(4) degradation relative to iron that has not been exposed to Na(2)S. However, continued aging of the FeS film results in breakdown and stress-induced cracking of the film, followed by dissolution and cracking of the iron itself.	Iron	4-7	C-C motif chemokine ligand 4	Homo sapiens	169-175
9630616-0	1998	Localization of transferrin binding protein in relation to iron, ferritin, and transferrin receptors in the chicken cerebellum.	Iron	59-63	heat shock protein 90 beta family member 1	Gallus gallus	16-43
18327971-5	2008	This review highlights the molecular mechanisms responsible for regulation of iron absorption, transport, and storage through the roles of key regulatory proteins, including ferroportin, hepcidin, ferritin, and frataxin.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	187-195
9585516-1	1998	A mononuclear iron-sulfur center, capable of reversible electron transfer, has been introduced into thioredoxin, a protein devoid of such sites, using an automated, structure-based design algorithm.	Iron	14-18	thioredoxin	Homo sapiens	100-111
18270695-3	2008	In this article, a systematic study of diffusive dynamics of ferritin and apoferritin (=ferritin without iron core) is presented.	Iron	105-109	ferritin heavy chain 1	Homo sapiens	74-85
9585516-2	1998	One of the sites predicted by the Dezymer computer program to introduce a tetrahedral tetrathiolate iron center included the intrinsic Cys32-Cys35 disulfide of wild-type thioredoxin and two additional mutants, Trp28Cys and Ile75Cys, thereby converting a disulfide into a metal-based redox center.	Iron	100-104	thioredoxin	Homo sapiens	170-181
9576873-1	1998	We investigated the geometry of the iron ligand sphere of the native rabbit 15-lipoxygenase (15-LOX) by X-ray absorption spectroscopy using synchrotron radiation.	Iron	36-40	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	93-99
18322939-9	2008	Chlorpyrifos and other phosphorothioates are potent inhibitors of the CYP-dependent metabolism of both endogenous substrates, such as testosterone and estradiol, and exogenous substrates, such as carbaryl, presumably as a result of the interaction of highly reactive sulfur, released during the oxidative desulfuration reaction, with the heme iron of CYP.	Iron	343-347	peptidylprolyl isomerase G	Homo sapiens	70-73
9576873-4	1998	From the positions of the absorption edges and from the intensities of the 1s-3d pre-edge transition peaks a six-coordinate ferrous iron was concluded for the rabbit 15-LOX.	Iron	132-136	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	166-172
9576873-10	1998	For construction of a structural model of the iron ligand sphere the binding distances extracted from the X-ray spectra were assigned to specific amino acids (His-360, -365, -540, -544 and the C-terminal Ile-662) by molecular modelling using the crystal coordinates of the soybean LOX-1 and of a rabbit 15-LOX-inhibitor complex.	Iron	46-50	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	303-309
19704577-3	2008	The expression of a ferric chelate reductase gene (NtFRO1) and an iron-regulated transporter gene (NtIRT1) in roots decreased by cutting off the leaves grown under the iron-deficient condition.	Iron	66-70	probable zinc transporter 10	Nicotiana tabacum	99-105
9627847-1	1998	Lactoferrin (Lf) is a milk iron-binding glycoprotein that plays a role in iron transport and acts as both a bacteriostatic and a growth modulating agent.	Iron	27-31	lactotransferrin	Mus musculus	0-11
9627847-1	1998	Lactoferrin (Lf) is a milk iron-binding glycoprotein that plays a role in iron transport and acts as both a bacteriostatic and a growth modulating agent.	Iron	27-31	lactotransferrin	Mus musculus	13-15
9558351-12	1998	These observations suggest that Lys72 can serve as an axial ligand to the heme iron of alkaline iso-1-ferricytochrome c if it is not modified posttranscriptionally to trimethyllysine.	Iron	79-83	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	96-101
18503700-1	2008	Hepcidin has recently been recognized as a hormone essential to the negative regulation of iron.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
9581919-0	1998	Comparison of image analysis, exertion force, and behavior measurements for use in the assessment of beef cattle responses to hot-iron and freeze branding.	Iron	130-134	alcohol dehydrogenase iron containing 1	Bos taurus	126-129
9581919-7	1998	Hot-iron-branded steers had greater maximum and average head movement distances and velocities than F or S steers (P &lt; .05), and F steers only had greater maximum values than S animals (P &lt; .05).	Iron	4-8	alcohol dehydrogenase iron containing 1	Bos taurus	0-3
18503700-2	2008	Synthesis of hepcidin is increased by iron overload or inflammation, and decreased by iron deficiency, anemia and erythropoietin.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	13-21
9581919-9	1998	Hot-iron-branded steers had the greatest incidence of tail-flicks, kicks, falls in the chute, and vocalizations, and S steers had the least.	Iron	4-8	alcohol dehydrogenase iron containing 1	Bos taurus	0-3
18503700-13	2008	Pro-hepcidin also showed an increase after ID was treated with iron administration (from 246.9 [205.5, 329.1] to 344.6 [290.1, 377.9] ng/mL; not significant).	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	4-12
9521625-9	1998	The divalent cation transporter 1 (DCT1) is regulated by iron, but exhibits transport activity for a number of trace elements including zinc.	Iron	57-61	solute carrier family 11 member 2	Homo sapiens	4-33
9521625-9	1998	The divalent cation transporter 1 (DCT1) is regulated by iron, but exhibits transport activity for a number of trace elements including zinc.	Iron	57-61	solute carrier family 11 member 2	Homo sapiens	35-39
18326817-1	2008	Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism.	Iron	120-124	hemojuvelin BMP co-receptor	Homo sapiens	0-11
9526564-5	1998	Spectroscopic studies with a modified form of human P450(17) alpha indicate that the inhibition process involves binding of steroidal azole nitrogen to the heme iron of the enzyme.	Iron	161-165	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	52-66
9514830-9	1998	In addition, excessive cellular levels of heme-derived free iron and carbon monoxide resulting from HO-1 overactivity may contribute to the pathogenesis of PD.	Iron	60-64	heme oxygenase 1	Homo sapiens	100-104
9559866-6	1998	GGT colocalized with iron deposition and was associated with increased GGT mRNA.	Iron	21-25	gamma-glutamyltransferase 1	Rattus norvegicus	0-3
9559866-9	1998	These results demonstrate that iron overload significantly alters the expression of antioxidant enzymes associated with glutathione (GGT and GST) and superoxide metabolism (CuZnSOD and MnSOD).	Iron	31-35	gamma-glutamyltransferase 1	Rattus norvegicus	133-136
9559866-10	1998	Furthermore, the localized induction of GGT may enhance detoxification of lipid peroxidation-derived aldehydes via glutathione-dependent pathways in iron-loaded hepatocytes.	Iron	149-153	gamma-glutamyltransferase 1	Rattus norvegicus	40-43
9613846-7	1998	The lack of enzymatic activity in the mR1-cR2 complex is attributed to perturbation or elimination of interactions linking the tyrosine radical/dinuclear iron center and the C-terminus within R2.	Iron	154-158	major histocompatibility complex, class I-related	Mus musculus	38-41
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Iron	31-35	matrix metallopeptidase 1	Homo sapiens	117-141
9478985-0	1998	Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.	Iron	31-35	matrix metallopeptidase 1	Homo sapiens	143-183
9478985-6	1998	The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed.	Iron	4-8	matrix metallopeptidase 1	Homo sapiens	258-263
9445478-0	1998	Role of ceruloplasmin in cellular iron uptake.	Iron	34-38	ceruloplasmin	Homo sapiens	8-21
9396728-4	1997	The results obtained indicate that His-13 of P21 co-ordinates to the sixth co-ordination position of the haem iron, thus leading to the formation of a complex characterized by an equilibrium between an "open" and a "closed" structure, as confirmed by molecular dynamics simulations.	Iron	110-114	H3 histone pseudogene 16	Homo sapiens	45-48
9396728-5	1997	Under acidic pH conditions, where His-13 of P21 is loosely bound to the haem iron ("open" conformation), MKP displays appreciable, quasi-reversible electrochemical activity; in contrast, at neutral pH ("closed" conformation) electrochemical behaviour is negligible, indicating that P21 interferes with the electron-transfer properties typical of Mp.	Iron	77-81	H3 histone pseudogene 16	Homo sapiens	44-47
9428742-0	1997	The ABC transporter Atm1p is required for mitochondrial iron homeostasis.	Iron	56-60	ATP binding cassette subfamily B member 7	Homo sapiens	20-25
9428742-5	1997	Mitochondria deficient in Atm1p accumulate 30-fold higher levels of free iron as compared to wild-type organelles, i.e. three-fold more than mitochondria deficient in frataxin, the protein mutated in Friedreich"s ataxia.	Iron	73-77	ATP binding cassette subfamily B member 7	Homo sapiens	26-31
9428742-6	1997	The increased mitochondrial iron content may be causative of the oxidative damage of heme-containing proteins in delta atm1 cells.	Iron	28-32	ATP binding cassette subfamily B member 7	Homo sapiens	119-123
9428742-7	1997	Our data assign an important function to Atm1p in mitochondrial iron homeostasis.	Iron	64-68	ATP binding cassette subfamily B member 7	Homo sapiens	41-46
15810238-0	1997	[SERS and electrochemistry studies on the inhibition of thiourea and phenyl-thiourea on iron].	Iron	88-92	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	1-5
9510925-8	1997	Of these 18 (18%) had haemoglobin less than 12 g dL-1 and 16 were treated with iron.	Iron	79-83	Galactose-specific C-type lectin	Drosophila melanogaster	49-60
9434348-4	1997	In this study we demonstrate that proteins encoded by genes previously demonstrated to play critical roles in vacuole assembly for acidification, PEP3, PEP5 and VMA3, are also required for normal copper and iron metal ion homeostasis.	Iron	207-211	tethering complex subunit PEP5	Saccharomyces cerevisiae S288C	152-156
9434348-5	1997	Yeast cells lacking a functional PEP3 or PEP5 gene are hypersensitive to copper and render the normally iron-repressible FET3 gene, encoding a multi-copper Fe(II) oxidase involved in Fe2+ transport, also repressible by exogenous copper ions.	Iron	104-108	tethering complex subunit PEP5	Saccharomyces cerevisiae S288C	41-45
9367531-0	1997	Stimulation of the ferroxidase activity of ceruloplasmin during iron loading into ferritin.	Iron	64-68	ceruloplasmin	Homo sapiens	43-56
9367531-1	1997	Ceruloplasmin purified from horse serum was rapidly reduced upon addition of increasing equivalents of ferrous iron, generating an electronically and conformationally distinct form.	Iron	111-115	ceruloplasmin	Homo sapiens	0-13
9367531-5	1997	The magnitude of this stimulatory effect increased as the molar ratio of ceruloplasmin to apoferritin approached 1.0, shown previously to be the optimum ratio for loading iron into ferritin.	Iron	171-175	ceruloplasmin	Homo sapiens	73-86
9367531-5	1997	The magnitude of this stimulatory effect increased as the molar ratio of ceruloplasmin to apoferritin approached 1.0, shown previously to be the optimum ratio for loading iron into ferritin.	Iron	171-175	ferritin heavy chain 1	Homo sapiens	90-101
9367531-6	1997	The rate of ferrous iron oxidation by ceruloplasmin was significantly stimulated by the presence of apoferritin; however, apotransferrin had no effect.	Iron	20-24	ceruloplasmin	Homo sapiens	38-51
9367531-6	1997	The rate of ferrous iron oxidation by ceruloplasmin was significantly stimulated by the presence of apoferritin; however, apotransferrin had no effect.	Iron	20-24	ferritin heavy chain 1	Homo sapiens	100-111
9367531-7	1997	The length of time required for ceruloplasmin to oxidize all the iron and return to the native form of the enzyme was also affected by the concentration of iron.	Iron	65-69	ceruloplasmin	Homo sapiens	32-45
9367531-7	1997	The length of time required for ceruloplasmin to oxidize all the iron and return to the native form of the enzyme was also affected by the concentration of iron.	Iron	156-160	ceruloplasmin	Homo sapiens	32-45
9367531-9	1997	These results provide evidence for the formation of a specific complex between the reduced form of ceruloplasmin and apoferritin and that reduction of ceruloplasmin by ferrous iron may be the signal for complex formation.	Iron	168-180	ceruloplasmin	Homo sapiens	99-112
9367531-9	1997	These results provide evidence for the formation of a specific complex between the reduced form of ceruloplasmin and apoferritin and that reduction of ceruloplasmin by ferrous iron may be the signal for complex formation.	Iron	168-180	ceruloplasmin	Homo sapiens	151-164
9353309-8	1997	Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells.	Iron	29-33	Mft1p	Saccharomyces cerevisiae S288C	84-88
9353309-8	1997	Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells.	Iron	52-56	Mft1p	Saccharomyces cerevisiae S288C	84-88
9353309-8	1997	Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells.	Iron	52-56	Mft1p	Saccharomyces cerevisiae S288C	84-88
9518065-2	1997	Following autophagocytosis of endogenous ferritin/apoferritin, these compounds may serve as chelators of such lysosomal iron and counteract the occurrence of iron-mediated intralysosomal oxidative reactions.	Iron	120-124	ferritin heavy chain 1	Homo sapiens	50-61
9518065-2	1997	Following autophagocytosis of endogenous ferritin/apoferritin, these compounds may serve as chelators of such lysosomal iron and counteract the occurrence of iron-mediated intralysosomal oxidative reactions.	Iron	158-162	ferritin heavy chain 1	Homo sapiens	50-61
9518065-4	1997	In this study we have shown: (i) human monocyte-derived macrophages to accumulate ferritin in response to iron exposure; (ii) iron to destabilise macrophage secondary lysosomes when the cells are exposed to H2O2; and (iii) endocytosed apoferritin to act as a stabiliser of the acidic vacuolar compartment of iron-loaded macrophages.	Iron	126-130	ferritin heavy chain 1	Homo sapiens	235-246
9518065-4	1997	In this study we have shown: (i) human monocyte-derived macrophages to accumulate ferritin in response to iron exposure; (ii) iron to destabilise macrophage secondary lysosomes when the cells are exposed to H2O2; and (iii) endocytosed apoferritin to act as a stabiliser of the acidic vacuolar compartment of iron-loaded macrophages.	Iron	126-130	ferritin heavy chain 1	Homo sapiens	235-246
9598790-6	1997	In all cases, the common source of stored iron for development was ferritin.	Iron	42-46	ferritin-1, chloroplastic	Glycine max	67-75
9598790-7	1997	The protein component of ferritin concentrates iron billions of times above the solubility of the free metal ion.	Iron	47-51	ferritin-1, chloroplastic	Glycine max	25-33
9335524-4	1997	On the contrary, sulfaphenazole led to a low-spin (S = 1/2) CYP 2C9 complex upon binding of its NH2 group to CYP 2C9 iron.	Iron	117-121	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	60-67
9335524-4	1997	On the contrary, sulfaphenazole led to a low-spin (S = 1/2) CYP 2C9 complex upon binding of its NH2 group to CYP 2C9 iron.	Iron	117-121	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	109-116
9335524-5	1997	Interactions of the five substrates with the enzyme were studied by paramagnetic relaxation effects of CYP 2C9-iron(III) on the 1H NMR spectrum of each substrate.	Iron	111-115	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-110
9335524-7	1997	Finally, a model for substrate positioning in the CYP 2C9 active site was constructed by molecular modeling studies under the constraint of the iron-proton distances.	Iron	144-148	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	50-57
9335524-9	1997	Sulfaphenazole was easily included in that model; its very high affinity for CYP 2C9 is due to a third structural feature, the presence of its NH2 function which binds to CYP 2C9 iron.	Iron	179-183	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	77-84
9335524-9	1997	Sulfaphenazole was easily included in that model; its very high affinity for CYP 2C9 is due to a third structural feature, the presence of its NH2 function which binds to CYP 2C9 iron.	Iron	179-183	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	171-178
9325328-16	1997	Furthermore, tumor necrosis factor and interleukin-1 activate NF-kappaB through different mechanisms in ECV304 cells, with the tumor necrosis factor pathway involving iron-catalyzed lipid peroxidation.	Iron	167-171	interleukin 1 alpha	Homo sapiens	39-52
9338620-2	1997	In patients who do not become dependent upon blood transfusion until adulthood (ANT-patients), iron chelation by desferrioxamine may affect the cardiac function in unknown ways, presumably because age-related changes in the heart may cause iron chelation to affect the cardiac function in different ways.	Iron	95-99	solute carrier family 25 member 6	Homo sapiens	80-83
9338620-3	1997	We therefore followed the left ventricular ejection fraction (LVEF) by multigated radionuclide angiography in 16 iron-loaded ANT-patients during iron chelation alone and after increasing the efficacy of chelation by vitamin C supplementation.	Iron	113-117	solute carrier family 25 member 6	Homo sapiens	125-128
9380735-0	1997	Heme oxygenase 1 is required for mammalian iron reutilization.	Iron	43-47	heme oxygenase 1	Homo sapiens	0-16
9257859-13	1997	Monocytic cell-derived ceruloplasmin may contribute to defense responses via its ferroxidase activity, which may drive iron homeostasis in a direction unfavorable to invasive organisms.	Iron	119-123	ceruloplasmin	Homo sapiens	23-36
9271100-9	1997	Evidence showing modulation of Nramp1 protein levels by iron chelation provides a direct link with Nramp1 function and divalent-cation metabolism.	Iron	56-60	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	99-105
9410471-0	1997	Impact of HLA-H mutations on iron stores in healthy elderly men and women.	Iron	29-33	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	10-15
9410471-7	1997	More men, 15 of 28, (54%) with estimated iron stores in the upper quartile, &gt;/= 1,050 mg, had a HLA-H mutation compared to 25 of 83 (30%) who had a mutation and whose estimated iron stores were &lt; ,050 mg, P&lt;0.05.	Iron	41-45	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	99-104
9263052-0	1997	Behavior of cattle during hot-iron and freeze branding and the effects on subsequent handling ease.	Iron	30-34	alcohol dehydrogenase iron containing 1	Bos taurus	26-29
9263052-5	1997	Hot-iron-branded steers had greater tail-flick, kick, fall and vocalization frequencies than freeze-branded or sham-branded animals (P &lt; .005).	Iron	4-8	alcohol dehydrogenase iron containing 1	Bos taurus	0-3
9263052-7	1997	The average and maximum exertion forces and the duration of force were greater in hot-iron-than in freeze- and sham-branded steers (P &lt; .001); freeze branded steers had greater values than shams (P &lt; .001).	Iron	86-90	alcohol dehydrogenase iron containing 1	Bos taurus	82-85
18326817-1	2008	Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism.	Iron	120-124	hemojuvelin BMP co-receptor	Homo sapiens	13-16
9263052-10	1997	Results indicate that hot-iron-branded steers experienced more discomfort at the time of branding than freeze-branded and sham steers, and freeze-branded steers experienced more discomfort than shams.	Iron	26-30	alcohol dehydrogenase iron containing 1	Bos taurus	22-25
18326817-1	2008	Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism.	Iron	120-124	bone morphogenetic protein 1	Homo sapiens	38-64
18326817-1	2008	Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism.	Iron	120-124	bone morphogenetic protein 1	Homo sapiens	66-69
18189270-0	2008	Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats.	Iron	83-87	erythropoietin	Rattus norvegicus	116-130
9242408-7	1997	DCT1 is upregulated by dietary iron deficiency, and may represent a key mediator of intestinal iron absorption.	Iron	31-35	solute carrier family 11 member 2	Homo sapiens	0-4
17997113-1	2008	Mutations in the SLC40A1 gene result in a dominant genetic disorder [ferroportin disease; hereditary hemochromatosis type (HH) IV], characterized by iron overload with two different clinical manifestations, normal transferrin saturation with macrophage iron accumulation (the most prevalent type) or high transferrin saturation with hepatocyte iron accumulation (classical hemochromatosis phenotype).	Iron	149-153	solute carrier family 40 member 1	Homo sapiens	17-24
9247149-0	1997	Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells.	Iron	57-61	ceruloplasmin	Homo sapiens	0-13
9247149-3	1997	Release was also accelerated by ceruloplasmin; most importantly, the effect of this protein was greatest when iron release was occurring rapidly, stimulated by apotransferrin, or under conditions of limited oxygen.	Iron	110-114	ceruloplasmin	Homo sapiens	32-45
17997113-1	2008	Mutations in the SLC40A1 gene result in a dominant genetic disorder [ferroportin disease; hereditary hemochromatosis type (HH) IV], characterized by iron overload with two different clinical manifestations, normal transferrin saturation with macrophage iron accumulation (the most prevalent type) or high transferrin saturation with hepatocyte iron accumulation (classical hemochromatosis phenotype).	Iron	253-257	solute carrier family 40 member 1	Homo sapiens	17-24
9207438-0	1997	Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion.	Iron	139-143	thrombopoietin	Macaca mulatta	34-48
17997113-1	2008	Mutations in the SLC40A1 gene result in a dominant genetic disorder [ferroportin disease; hereditary hemochromatosis type (HH) IV], characterized by iron overload with two different clinical manifestations, normal transferrin saturation with macrophage iron accumulation (the most prevalent type) or high transferrin saturation with hepatocyte iron accumulation (classical hemochromatosis phenotype).	Iron	253-257	solute carrier family 40 member 1	Homo sapiens	17-24
17997113-4	2008	This protocol turned out to be rapid, sensitive and reliable, facilitating the detection of the SLC40A1 gene mutations in two patients with hyperferritinemia, normal transferrin saturation and iron accumulation predominantly in macrophages and Kupffer cells.	Iron	193-197	solute carrier family 40 member 1	Homo sapiens	96-103
9207438-7	1997	Iron depletion was demonstrated by measurements of total serum iron and total iron-binding capacity (TIBC) and could be prevented by prophylactic intramuscular (IM) iron before TBI or corrected by IM iron after TPO treatment.	Iron	0-4	thrombopoietin	Macaca mulatta	211-214
18023212-5	2008	Results showed that sTfR highly associates with erythropoietic activity that strongly interfered with the iron store regulation of hepcidin.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	131-139
9207438-10	1997	It is postulated that the extremely rapid erythropoiesis due to TPO treatment in the initial regeneration phase following myelosuppression results in iron depletion by a mechanism similar to that seen following erythropoietin treatment in patients with end-stage renal failure.	Iron	150-154	thrombopoietin	Macaca mulatta	64-67
9207438-11	1997	It is concluded that protracted TPO therapy to counteract thrombocytopenic states may result in iron depletion and that the iron status should be monitored before, during, and after TPO treatment.	Iron	96-100	thrombopoietin	Macaca mulatta	32-35
18408455-6	2008	Hepcidin plays a key role in modulating iron uptake in iron-overload disorders and new studies elucidate hepcidin regulation.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
9237628-0	1997	Iron triggers a rapid induction of ascorbate peroxidase gene expression in Brassica napus.	Iron	0-4	peroxidase A2	Brassica napus	45-55
9237628-2	1997	Here it is demonstrated that an iron overload of Brassica napus seedlings causes a large and rapid accumulation of ascorbate peroxidase transcripts, a plant-specific hydrogen peroxide-scavenging enzyme.	Iron	32-36	peroxidase A2	Brassica napus	125-135
18408455-6	2008	Hepcidin plays a key role in modulating iron uptake in iron-overload disorders and new studies elucidate hepcidin regulation.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
9237628-5	1997	Furthermore, the iron-induced ascorbate peroxidase mRNA accumulation was not antagonized by N-acetyl cysteine.	Iron	17-21	peroxidase A2	Brassica napus	40-50
9237628-7	1997	Taken together these results suggest that iron-mediated expression of ascorbate peroxidase gene occurs through a signal transduction pathway apparently different from those already described for plant genes responsive to oxidative stress.	Iron	42-46	peroxidase A2	Brassica napus	80-90
18313788-1	2008	BACKGROUND/AIMS: Hepcidin is a liver-produced hormone that regulates systemic iron homeostasis.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	17-25
9180188-4	1997	CD4 T cells from spleens of iron-overloaded mice were found to produce high levels of IL-4 and IL-10 and low levels of interferon-gamma.	Iron	28-32	interleukin 4	Mus musculus	86-90
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	48-52	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	39-44
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	110-114	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	39-44
9083055-5	1997	Yeast strains lacking ATX1 are deficient in high affinity iron uptake and expression of HAH1 in these strains permits growth on iron-depleted media and results in restoration of copper incorporation into newly synthesized Fet3p.	Iron	58-62	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	22-26
9083055-5	1997	Yeast strains lacking ATX1 are deficient in high affinity iron uptake and expression of HAH1 in these strains permits growth on iron-depleted media and results in restoration of copper incorporation into newly synthesized Fet3p.	Iron	128-132	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	22-26
18313788-2	2008	Hepcidin expression is stimulated upon iron overload or inflammation while iron deficiency, anemia and tissue hypoxia are negative regulators.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
18421430-1	2008	The precise regulation of the iron-regulatory hormone hepcidin is essential to maintain body iron homeostasis: Hepcidin deficiency induces iron overload, and hepcidin excess results in anaemia.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	54-62
9115760-5	1997	Control groups of rats that were unexposed or exposed to an aerosol of iron beads were negative for p53 immunostaining throughout the 30-day assessment period.	Iron	71-75	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	100-103
18421430-1	2008	The precise regulation of the iron-regulatory hormone hepcidin is essential to maintain body iron homeostasis: Hepcidin deficiency induces iron overload, and hepcidin excess results in anaemia.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	111-119
18421430-1	2008	The precise regulation of the iron-regulatory hormone hepcidin is essential to maintain body iron homeostasis: Hepcidin deficiency induces iron overload, and hepcidin excess results in anaemia.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	158-166
18421430-1	2008	The precise regulation of the iron-regulatory hormone hepcidin is essential to maintain body iron homeostasis: Hepcidin deficiency induces iron overload, and hepcidin excess results in anaemia.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	54-62
18424595-0	2008	Ferritin-iron is released during boiling and in vitro gastric digestion.	Iron	9-13	ferritin-1, chloroplastic	Glycine max	0-8
9119894-0	1997	Iron-loading of cultured adult rat hepatocytes reversibly enhances lactoferrin binding and endocytosis.	Iron	0-4	lactotransferrin	Rattus norvegicus	67-78
18424595-1	2008	Biofortification of staple foods with iron in the form of ferritin-iron is a promising approach to fighting iron-deficiency anemia in developing countries.	Iron	38-42	ferritin-1, chloroplastic	Glycine max	58-66
18424595-1	2008	Biofortification of staple foods with iron in the form of ferritin-iron is a promising approach to fighting iron-deficiency anemia in developing countries.	Iron	67-71	ferritin-1, chloroplastic	Glycine max	58-66
18424595-2	2008	However, contradictory results regarding iron bioavailability to humans from ferritin are not yet fully clarified.	Iron	41-45	ferritin-1, chloroplastic	Glycine max	77-85
18424595-4	2008	We studied changes of ferritin-iron and protein during cooking and in vitro gastric digestion.	Iron	31-35	ferritin-1, chloroplastic	Glycine max	22-30
9149961-8	1997	The results confirmed and extended those of earlier studies suggesting that the bactericidal domain of lactoferrin was localized in the N-terminus and did not involve iron-binding sites.	Iron	167-171	lactotransferrin	Bos taurus	103-114
18424595-5	2008	Water soluble, native ferritin-iron, measured in different legumes, represented 18% (soybeans) up to maximally 42% (peas) of total seed iron.	Iron	31-35	ferritin-1, chloroplastic	Glycine max	22-30
18424595-5	2008	Water soluble, native ferritin-iron, measured in different legumes, represented 18% (soybeans) up to maximally 42% (peas) of total seed iron.	Iron	136-140	ferritin-1, chloroplastic	Glycine max	22-30
9029007-0	1997	Iron metabolism in transgenic mice with hypoplastic anaemia due to incomplete deficiency of erythropoietin.	Iron	0-4	erythropoietin	Mus musculus	92-106
18424595-7	2008	When the same cooking treatment was applied to recombinant bean ferritin propagated in Escherichia coli, some ferritin-iron remained measurable.	Iron	119-123	ferritin-1, chloroplastic	Glycine max	64-72
18424595-7	2008	When the same cooking treatment was applied to recombinant bean ferritin propagated in Escherichia coli, some ferritin-iron remained measurable.	Iron	119-123	ferritin-1, chloroplastic	Glycine max	110-118
18424595-8	2008	During in vitro gastric digestion of recombinant bean ferritin and red kidney bean extract, ferritin-iron was fully released from the protein and dissolved at pH 2.	Iron	101-105	ferritin-1, chloroplastic	Glycine max	54-62
9159867-4	1997	Iron deficiency increased the mRNA level of genes of apolipoprotein AIV and class 1 antigen and decreased the mRNA level of the apolipoprotein AI gene and of an unknown gene, while no change was found in the mRNA level of the gene of fatty acid-binding protein.	Iron	0-4	apolipoprotein A1	Rattus norvegicus	53-70
18424595-8	2008	During in vitro gastric digestion of recombinant bean ferritin and red kidney bean extract, ferritin-iron was fully released from the protein and dissolved at pH 2.	Iron	101-105	ferritin-1, chloroplastic	Glycine max	92-100
9159867-5	1997	Excess of dietary iron resulted in the increase in mRNA of this gene and in a decrease in the apolipoprotein AI gene and in the unknown gene.	Iron	18-22	apolipoprotein A1	Rattus norvegicus	94-111
18424595-9	2008	Stability tests at varying pH at 37 degrees C showed that the release of ferritin-iron starts at pH 5 and is complete at pH 2.	Iron	82-86	ferritin-1, chloroplastic	Glycine max	73-81
18311828-0	2008	High brain iron level in asymptomatic carriers of heterozygous ceruloplasmin gene mutations.	Iron	11-15	ceruloplasmin	Homo sapiens	63-76
18398482-4	2008	XLSA/A is caused by partial inactivating mutations of the ABCB7 ATP-binding cassette transporter gene, which functions to enable transport of iron from the mitochondria to the cytoplasm.	Iron	142-146	ATP binding cassette subfamily B member 7	Homo sapiens	58-63
9368100-1	1997	Hypoxia inducible factor 1 alpha (HIF-1 alpha) is a basic helix-loop-helix-PAS (bHLH-PAS) transcription factor that mediates certain cellular responses to low oxygen tension, iron chelators, Co2+, Ni2+, Mg2+, and low intracellular glucose concentration.	Iron	175-179	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-32
9368100-1	1997	Hypoxia inducible factor 1 alpha (HIF-1 alpha) is a basic helix-loop-helix-PAS (bHLH-PAS) transcription factor that mediates certain cellular responses to low oxygen tension, iron chelators, Co2+, Ni2+, Mg2+, and low intracellular glucose concentration.	Iron	175-179	hypoxia inducible factor 1, alpha subunit	Mus musculus	34-45
8977218-0	1997	Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.	Iron	42-46	interleukin 4	Mus musculus	93-97
8977218-2	1997	To elucidate the influence of the Th2 cytokines IL-4 and IL-13 on macrophage iron metabolism, we investigated activated primary mouse macrophages and the murine macrophage cell line J774.	Iron	77-81	heart and neural crest derivatives expressed 2	Mus musculus	34-37
8977218-8	1997	Thus, IL-4 and IL-13 regulate the iron metabolism of activated macrophages by at least two different pathways: first, by opposing NO-mediated IRP activation, thereby increasing ferritin translation; and second, by an IRP-independent augmentation of TfR mRNA expression.	Iron	34-38	interleukin 4	Mus musculus	6-10
8977218-9	1997	We suggest that IL-4 and IL-13 may enhance iron uptake and storage in activated macrophages and thereby contribute to down-regulation of macrophage effector functions.	Iron	43-47	interleukin 4	Mus musculus	16-20
18398482-5	2008	Furthermore, ABCB7 gene silencing in HeLa cells causes an accumulation of iron in the mitochondria.	Iron	74-78	ATP binding cassette subfamily B member 7	Homo sapiens	13-18
18027835-4	2008	The reticulocyte hemoglobin content (CHr or Ret-He) provides an indirect measure of the functional iron available for new red blood cell production over the previous 3-4 days.	Iron	99-103	ret proto-oncogene	Homo sapiens	44-47
9372861-0	1997	Effects of intracellular chelatable iron and oxidative stress on transcription of classical cellular glutathione peroxidase gene in murine erythroleukemia cells.	Iron	36-40	glutathione peroxidase 1	Mus musculus	92-123
9372861-3	1997	Transcription in vitro in isolated nuclei from treated cells showed that the treatment with iron chelators (desferrioxamine (DFO), pyridoxal isonictinoyl hydrazone (PIH) decreased the rate of nuclear GSHPx-1 RNA nascent chain elongation in both uninduced and with 5 mmol hexamethylenebisacetamide (HMBA) to erythroid differentiation induced MEL cells.	Iron	92-96	glutathione peroxidase 1	Mus musculus	200-207
9372861-4	1997	Iron donors (diferric transferrin, Fe-PIH or their combination) and t-butyl hydroperoxide (t-BuOOH) had the opposite effect on GSHPx-1 gene transcription in run-on experiments.	Iron	0-4	glutathione peroxidase 1	Mus musculus	127-134
18287331-0	2008	Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.	Iron	65-69	hemojuvelin BMP co-receptor	Homo sapiens	21-25
8969232-7	1996	Among these genes, only AtCLC-d could functionally substitute for the single yeast CLC protein, restoring iron-limited growth of a strain disrupted for this gene.	Iron	106-110	chloride channel D	Arabidopsis thaliana	24-31
18287331-0	2008	Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.	Iron	65-69	hemojuvelin BMP co-receptor	Homo sapiens	26-37
18287331-1	2008	Juvenile hemochromatosis is a severe and rapidly progressing hereditary disorder of iron overload, and it is caused primarily by defects in the gene encoding repulsive guidance molecule c/hemojuvelin (RGMc/HJV), a recently identified protein that undergoes a complicated biosynthetic pathway in muscle and liver, leading to cell membrane-linked single-chain and heterodimeric species, and two secreted single-chain isoforms.	Iron	84-88	hemojuvelin BMP co-receptor	Homo sapiens	158-187
18287331-1	2008	Juvenile hemochromatosis is a severe and rapidly progressing hereditary disorder of iron overload, and it is caused primarily by defects in the gene encoding repulsive guidance molecule c/hemojuvelin (RGMc/HJV), a recently identified protein that undergoes a complicated biosynthetic pathway in muscle and liver, leading to cell membrane-linked single-chain and heterodimeric species, and two secreted single-chain isoforms.	Iron	84-88	hemojuvelin BMP co-receptor	Homo sapiens	188-199
9010829-1	1996	Recently we have shown that ACE inhibitors and platelet activating factor antagonists inhibit iron-dependent lipid peroxidation in murine ventricular membranes and possess beneficial effects on ischemia and ischemia reperfusion-induced myocardial injury, which has been ascribed to their capacity to scavenge or impair oxygen free radical generation.	Iron	94-98	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	28-31
18287331-1	2008	Juvenile hemochromatosis is a severe and rapidly progressing hereditary disorder of iron overload, and it is caused primarily by defects in the gene encoding repulsive guidance molecule c/hemojuvelin (RGMc/HJV), a recently identified protein that undergoes a complicated biosynthetic pathway in muscle and liver, leading to cell membrane-linked single-chain and heterodimeric species, and two secreted single-chain isoforms.	Iron	84-88	hemojuvelin BMP co-receptor	Homo sapiens	201-205
18287331-1	2008	Juvenile hemochromatosis is a severe and rapidly progressing hereditary disorder of iron overload, and it is caused primarily by defects in the gene encoding repulsive guidance molecule c/hemojuvelin (RGMc/HJV), a recently identified protein that undergoes a complicated biosynthetic pathway in muscle and liver, leading to cell membrane-linked single-chain and heterodimeric species, and two secreted single-chain isoforms.	Iron	84-88	hemojuvelin BMP co-receptor	Homo sapiens	206-209
18321995-1	2008	Lactoferrin (LF) is an iron-binding protein found in milk, mucosal secretions, and the secondary granules of neutrophils in which it is considered to be an important factor in the innate immune response against microbial infections.	Iron	23-27	lactotransferrin	Mus musculus	0-11
8841125-2	1996	Temperature dependent splitting also occurs for zinc cytochrome c, a derivative in which Fe has been replaced by Zn; at 10 K, the peaks in the Q0,0 band region occur at 17 106 and 16 996 cm-1.	Iron	89-91	cytochrome c, somatic	Equus caballus	53-65
18321995-1	2008	Lactoferrin (LF) is an iron-binding protein found in milk, mucosal secretions, and the secondary granules of neutrophils in which it is considered to be an important factor in the innate immune response against microbial infections.	Iron	23-27	lactotransferrin	Mus musculus	13-15
17767813-1	2008	OBJECTIVE: Deferoxamine, an iron chelator, is reported to induce hypoxia-inducible factor 1 (HIF-1) that leads to transcriptional activation of numerous genes including vascular endothelial growth factor (VEGF) that is known to increase blood-brain barrier (BBB) permeability.	Iron	28-32	vascular endothelial growth factor A	Rattus norvegicus	169-203
8887268-3	1996	Cimetidine, which inhibits cytochrome P-450 by interacting with the heme iron, significantly blocked iron release, whereas ranitidine, which has a similar structure as cimetidine but is a weak inhibitor of P-450, did not have an effect (H2O2, 0.42 +/- 0.04; H2O2 + cimetidine, 0.23 +/- 0.02 nmol/mg protein; N = 4, P &lt; 0.01).	Iron	73-77	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	27-43
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Iron	41-45	heme oxygenase 1	Homo sapiens	0-16
8874735-16	1996	Locally produced lactoferrin may bathe the ocular surface and sequester iron from potential pathogens.	Iron	72-76	lactotransferrin	Bos taurus	17-28
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Iron	41-45	heme oxygenase 1	Homo sapiens	18-22
9009670-4	1996	The mechanism by which an HLA-H defect alters iron metabolism is still unidentified.	Iron	46-50	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	26-31
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Iron	103-107	heme oxygenase 1	Homo sapiens	0-16
8679612-0	1996	Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron.	Iron	179-183	peroxiredoxin 5	Homo sapiens	44-65
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Iron	103-107	heme oxygenase 1	Homo sapiens	18-22
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Iron	103-107	heme oxygenase 1	Homo sapiens	0-16
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Iron	103-107	heme oxygenase 1	Homo sapiens	18-22
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Iron	212-216	heme oxygenase 1	Homo sapiens	17-21
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Iron	212-216	heme oxygenase 1	Homo sapiens	239-243
18061239-8	2008	The high efficiency of the composite Fe(0)/Fe3O4 for Cr(VI) reduction is discussed in terms of a special mechanism where an electron is transferred from Fe(0) to magnetite to reduce Fe(oct)3+ to Fe(oct)2+, which is active for Cr(VI) reduction.	Iron	153-158	POU class 5 homeobox 1	Homo sapiens	182-190
18245275-2	2008	Alternative pathways for iron assimilation, such as those involving ZIP family transporters IRT1 and IRT2, may be operational.	Iron	25-29	allograft inflammatory factor 1	Homo sapiens	92-96
8641692-2	1996	Loss of the ferroxidase activity of ceruloplasmin results in systemic iron deposition and tissue damage.	Iron	70-74	ceruloplasmin	Homo sapiens	36-49
18488871-0	2008	[Hepcidin--the discovery of a small protein with a pivotal role in iron homeostasis].	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	1-9
8671340-6	1996	In particular, the concentration of iron and the ration of T2SI/ MSI were inversely proportional.	Iron	36-40	RB binding protein 4, chromatin remodeling factor	Homo sapiens	65-68
18488871-3	2008	Soon after, hepcidin was recognized as a key component in iron homeostasis, involved in maladies of iron overload or iron deficiency.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	12-20
8671340-7	1996	Therefore, T2SI/MSI reflected the concentration of iron in endometriomas without recourse to measurement of the calculated T2 value, which suggests that the MRI and T2 signal intensity may be useful for evaluating the cyst fluid characteristics of endometriomas.	Iron	51-55	RB binding protein 4, chromatin remodeling factor	Homo sapiens	16-19
18488871-4	2008	Hepcidin acts by binding to the transmembrane protein ferroportin, in charge of exporting iron from cells.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
18488871-6	2008	In hereditary and juvenile types of hemochromatosis, iron overload could be partially due to the down-regulation of hepcidin by the mutated genes HFE and HJV.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	116-124
18488871-6	2008	In hereditary and juvenile types of hemochromatosis, iron overload could be partially due to the down-regulation of hepcidin by the mutated genes HFE and HJV.	Iron	53-57	hemojuvelin BMP co-receptor	Homo sapiens	154-157
18488871-7	2008	In ferroportin disease, hepcidin synthesis is not inhibited, yet cells are still overloaded with iron due to mutations in ferroportin, preventing the binding of hepcidin and iron export from cell to the blood.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	161-169
8698845-2	1996	Addition of the iron-sulphur cluster nitrosyl Roussin"s black salt (RBS, heptanitrosyl-tri-mu3-thioxotetraferrate (1-)) resulted in a rapid and dose-dependent (50-250 microM) decline in the electrical resistance displayed by co-cultures of vascular endothelial cells and C6 glioma cells.	Iron	16-20	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	68-71
18488871-11	2008	Future therapeutic approach may attempt administering synthetic hepcidin, or its antagonists, to correct states of iron overload or scarcity.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	64-72
18268518-0	2008	"Iron-saturated" lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapy.	Iron	1-5	lactotransferrin	Mus musculus	17-28
8992201-3	1996	Ferritin-induced water relaxation showed quadratic dependence on the iron loading factor, implying a paramagnetic mechanism.	Iron	69-73	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	0-8
18268518-1	2008	Bovine lactoferrin (bLf), an iron-containing natural defence protein found in bodily secretions, has been reported to inhibit carcinogenesis and the growth of tumours.	Iron	29-33	lactotransferrin	Mus musculus	7-18
18336670-3	2008	Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the increased expression of transferrin receptor (TfR) 1; and increased intestinal iron absorption by the lowering of hepcidin.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	229-237
8739601-4	1996	HLf and BLf exerted their activity through the inhibition of adsorption of virions to the cells independently of their iron withholding property showing similar activity in the apo- and iron-saturated form.	Iron	119-123	HLF transcription factor, PAR bZIP family member	Homo sapiens	0-3
8739601-4	1996	HLf and BLf exerted their activity through the inhibition of adsorption of virions to the cells independently of their iron withholding property showing similar activity in the apo- and iron-saturated form.	Iron	186-190	HLF transcription factor, PAR bZIP family member	Homo sapiens	0-3
18326317-4	2008	Recently, a new anti-microbial peptide, named hepcidin, was identified, and hepcidin is found to function as the regulator of body iron metabolism by inhibiting iron uptake at enterocyte and iron release from reticuloendothelial macrophages.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	46-54
18326317-4	2008	Recently, a new anti-microbial peptide, named hepcidin, was identified, and hepcidin is found to function as the regulator of body iron metabolism by inhibiting iron uptake at enterocyte and iron release from reticuloendothelial macrophages.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	76-84
8708108-0	1996	Effect of supplemental lactoferrin with ferrous iron on iron status of newborn calves.	Iron	56-60	lactotransferrin	Bos taurus	23-34
8708108-9	1996	Plasma Fe of calves treated with Fe or Fe plus lactoferrin increased temporarily at d 2 of age.	Iron	7-9	lactotransferrin	Bos taurus	47-58
8708108-10	1996	Plasma Fe of calves treated with Fe plus lactoferrin at d 2 of age was lower than that of calves treated with Fe, but, at d 6 and 10 of age, plasma Fe of calves treated with Fe plus lactoferrin were higher.	Iron	7-9	lactotransferrin	Bos taurus	41-52
18326317-4	2008	Recently, a new anti-microbial peptide, named hepcidin, was identified, and hepcidin is found to function as the regulator of body iron metabolism by inhibiting iron uptake at enterocyte and iron release from reticuloendothelial macrophages.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	46-54
18326317-4	2008	Recently, a new anti-microbial peptide, named hepcidin, was identified, and hepcidin is found to function as the regulator of body iron metabolism by inhibiting iron uptake at enterocyte and iron release from reticuloendothelial macrophages.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	76-84
18326317-4	2008	Recently, a new anti-microbial peptide, named hepcidin, was identified, and hepcidin is found to function as the regulator of body iron metabolism by inhibiting iron uptake at enterocyte and iron release from reticuloendothelial macrophages.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	46-54
8654390-1	1996	Heme oxygenase 1 is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, iron, and carbon monoxide.	Iron	97-101	heme oxygenase 1	Homo sapiens	0-16
18326317-4	2008	Recently, a new anti-microbial peptide, named hepcidin, was identified, and hepcidin is found to function as the regulator of body iron metabolism by inhibiting iron uptake at enterocyte and iron release from reticuloendothelial macrophages.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	76-84
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	49-57
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	176-180	solute carrier family 40 member 1	Homo sapiens	194-207
8789443-6	1996	Taken together the clinical and genetic data support the concept of an essential and unique role for ceruloplasmin in human iron metabolism.	Iron	124-128	ceruloplasmin	Homo sapiens	101-114
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	246-250	hepcidin antimicrobial peptide	Homo sapiens	49-57
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	246-250	solute carrier family 40 member 1	Homo sapiens	194-207
18326322-5	2008	So, the abnormal expression of hepcidin alone may be able to explain the unique iron metabolism in ACD.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	31-39
18330026-4	2008	The pathophysiology of the deficiency, clinical features, laboratory findings, diagnosis and treatment are discussed as well as the basic findings of iron absorption mechanism in which the newly found factors such as DMT-1 and hepcidin are involved.	Iron	150-154	doublesex and mab-3 related transcription factor 1	Homo sapiens	217-222
8560483-6	1996	The mechanism of the iron-enhanced toxicity may be due to oxidative damage associated with chronic induction of CYP1A1 isoforms.	Iron	21-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	112-118
18330026-4	2008	The pathophysiology of the deficiency, clinical features, laboratory findings, diagnosis and treatment are discussed as well as the basic findings of iron absorption mechanism in which the newly found factors such as DMT-1 and hepcidin are involved.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	227-235
8530520-2	1995	IRP-IRE interactions mediate the coordinate post-transcriptional regulation of key proteins in iron metabolism, such as ferritin, transferrin receptor, and erythroid 5-aminolevulinic acid synthase.	Iron	95-99	Iron regulatory protein 1B	Drosophila melanogaster	0-3
17700530-3	2008	Elevating cellular iron levels in Caco-2 and SW480 cells caused increased Wnt signalling as indicated by increased TOPFLASH reporter activity, increased mRNA expression of two known targets, c-myc and Nkd1, and increased cellular proliferation.	Iron	19-23	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	191-196
7578230-4	1995	It was found with flash photolysis that an electron from photo-reduced safranine T quickly reaches the heme iron of cytochrome P-450 1A2 (P-450 1A2).	Iron	108-112	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	116-136
17700530-6	2008	The cell line LS174T, wild type for APC but mutant for beta-catenin, was also responsive suggesting that the role of iron is to regulate beta-catenin.	Iron	117-121	catenin beta 1	Homo sapiens	137-149
18163543-10	2008	In contrast, when iron-treated mice received, instead of TCDD, the heme precursor 5-aminolevulinic acid (ALA), causing uroporphyia in Ahr (+/+) mice (242-fold rise in uroporphyrins), elevation of uroporphyrins I and III (42-fold) also occurred in Ahr (-/-) mice and was seemingly associated with AHR-independent expression of Cyp1a2.	Iron	18-22	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	326-332
7487902-0	1995	Isolated rat hepatocytes acquire iron from lactoferrin by endocytosis.	Iron	33-37	lactotransferrin	Rattus norvegicus	43-54
7487902-5	1995	When Lf was normalized for 59Fe content, these endocytic rates were equivalent and reflected an uptake potential of at least 3400 mol of iron.cell-1.s-1.	Iron	137-141	lactotransferrin	Rattus norvegicus	5-7
7487902-13	1995	It was concluded from this study that hepatocytes take up iron from Lf at high rates by a process that requires endocytosis of Lf-iron complexes.	Iron	58-62	lactotransferrin	Rattus norvegicus	68-70
7487902-13	1995	It was concluded from this study that hepatocytes take up iron from Lf at high rates by a process that requires endocytosis of Lf-iron complexes.	Iron	58-62	lactotransferrin	Rattus norvegicus	127-129
7487902-13	1995	It was concluded from this study that hepatocytes take up iron from Lf at high rates by a process that requires endocytosis of Lf-iron complexes.	Iron	130-134	lactotransferrin	Rattus norvegicus	68-70
18245657-1	2008	This work describes the identification of two subjects with young-age iron overload carrying new causative mutations in transferrin receptor-2 gene.	Iron	70-74	transferrin receptor 2	Homo sapiens	120-142
7487902-13	1995	It was concluded from this study that hepatocytes take up iron from Lf at high rates by a process that requires endocytosis of Lf-iron complexes.	Iron	130-134	lactotransferrin	Rattus norvegicus	127-129
7580053-1	1995	Ascorbate is catalytically oxidized by a couple iron-ceruloplasmin system, the iron ions functioning as a red/ox cycling intermediate between ceruloplasmin and ascorbate.	Iron	48-52	ceruloplasmin	Homo sapiens	53-66
7580053-1	1995	Ascorbate is catalytically oxidized by a couple iron-ceruloplasmin system, the iron ions functioning as a red/ox cycling intermediate between ceruloplasmin and ascorbate.	Iron	48-52	ceruloplasmin	Homo sapiens	142-155
7580054-8	1995	Iron is a poor inducer of metallothionein mRNA accumulation.	Iron	0-4	Metallothionein B	Drosophila melanogaster	26-41
18029358-2	2008	The archaeal Rad3 (xeroderma pigmentosum group D protein (XPD)) helicase is a prototypical member of the Rad3 family, distinct from other related (superfamily II) SF2 enzymes because of a unique insertion containing an iron-sulfur (FeS) cluster.	Iron	232-235	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	58-61
7556058-0	1995	A novel iron uptake mechanism mediated by GPI-anchored human p97.	Iron	8-12	melanotransferrin	Homo sapiens	61-64
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	32-36	melanotransferrin	Homo sapiens	16-19
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	32-36	melanotransferrin	Homo sapiens	124-127
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	100-104	melanotransferrin	Homo sapiens	16-19
17938254-2	2008	Hemojuvelin (HJV) has a key role in hepcidin regulation, and its inactivation causes severe iron overload both in humans and in mice.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	0-11
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	100-104	melanotransferrin	Homo sapiens	124-127
7556058-4	1995	The internalization of iron was shown to be temperature sensitive and saturated at a media iron concentration of 2.5 micrograms/ml with a Vmax of 0.1 pmol Fe/10(6) cell/min and a Km of 2.58 microM for p97.	Iron	23-27	melanotransferrin	Homo sapiens	201-204
17938254-2	2008	Hemojuvelin (HJV) has a key role in hepcidin regulation, and its inactivation causes severe iron overload both in humans and in mice.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	13-16
18021800-8	2008	Likewise, the purified Zn ribbon protein KTI11 from Saccharomyces cerevisiae had a purple color in solution and an Rd-like absorption spectrum, contained both iron and zinc, and was reduced by the Rd reductase NorW from E. coli.	Iron	159-163	Kti11p	Saccharomyces cerevisiae S288C	41-46
8576812-0	1995	Receptor-mediated binding of milk lactoferrin to nursing piglet enterocytes: a model for studies on absorption of lactoferrin-bound iron.	Iron	132-136	lactotransferrin	Bos taurus	114-125
8576812-1	1995	Lactoferrin, an iron-binding glycoprotein that is abundant in milk of some species, has been suggested to play a key role in the absorption of iron in human infants.	Iron	16-20	lactotransferrin	Bos taurus	0-11
19066076-8	2008	The effect of the iron chelator, deferoxamine, on PARP activation was also examined.	Iron	18-22	poly (ADP-ribose) polymerase 1	Rattus norvegicus	50-54
8576812-2	1995	This hypothesis is based on the dominant role of lactoferrin as an iron-binding component in human milk and on the occurrence of lactoferrin receptors in brush-border membranes in infants" intestines.	Iron	67-71	lactotransferrin	Bos taurus	49-60
17943020-1	2008	Hepcidin is a key regulator of iron metabolism.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
7619835-6	1995	Biophys Acta 974 (1989) 311-320), which predicts that Complex I is a heterodimer with promoter B, containing FMN and Fe-S clusters 1-4 in stiochiometric amounts, catalyzing NADH oxidation at pH 8, and Protomer A, containing FMN and Fe-S clusters 2, 4, catalyzing NAD(P)H oxidation at pH 6.5.	Iron	117-121	formin 1	Homo sapiens	224-227
7619835-6	1995	Biophys Acta 974 (1989) 311-320), which predicts that Complex I is a heterodimer with promoter B, containing FMN and Fe-S clusters 1-4 in stiochiometric amounts, catalyzing NADH oxidation at pH 8, and Protomer A, containing FMN and Fe-S clusters 2, 4, catalyzing NAD(P)H oxidation at pH 6.5.	Iron	232-236	formin 1	Homo sapiens	109-112
17962361-0	2008	Hepcidin inhibits apical iron uptake in intestinal cells.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
7672622-1	1995	BACKGROUND: Transferrin and Fe concentrations increase in the intraocular fluids in pathological conditions and the lens accumulates Fe during ocular inflammation.	Iron	133-135	inhibitor of carbonic anhydrase	Canis lupus familiaris	12-23
7672622-2	1995	Tissues take up Fe from transferrin by two mechanisms, receptor-medicated endocytosis of diferric transferrin and a process occurring at the cell membrane which may be mediated by an oxido-reductase.	Iron	16-18	inhibitor of carbonic anhydrase	Canis lupus familiaris	24-35
17962361-1	2008	Hepcidin (Hepc) is considered a key mediator in iron trafficking.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-8
7672622-2	1995	Tissues take up Fe from transferrin by two mechanisms, receptor-medicated endocytosis of diferric transferrin and a process occurring at the cell membrane which may be mediated by an oxido-reductase.	Iron	16-18	inhibitor of carbonic anhydrase	Canis lupus familiaris	98-109
17962361-1	2008	Hepcidin (Hepc) is considered a key mediator in iron trafficking.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-4
7672622-4	1995	This study was designed to characterize the uptake of Fe from transferrin by lens epithelial cells in culture.	Iron	54-56	inhibitor of carbonic anhydrase	Canis lupus familiaris	62-73
7672622-10	1995	CONCLUSIONS: The reduction of Fe uptake by the subcultured and cataract cell lines probably reflects a decrease in transferrin receptor expression and in the activity of an alternative pathway for Fe transferrin uptake occurring over time.	Iron	30-32	inhibitor of carbonic anhydrase	Canis lupus familiaris	115-126
17962361-3	2008	The current study investigated the effects of physiologically generated Hepc on iron transport in Caco-2 cell monolayers and rat duodenal segments compared with the effects on the J774 macrophage cell line.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	72-76
7672622-10	1995	CONCLUSIONS: The reduction of Fe uptake by the subcultured and cataract cell lines probably reflects a decrease in transferrin receptor expression and in the activity of an alternative pathway for Fe transferrin uptake occurring over time.	Iron	30-32	inhibitor of carbonic anhydrase	Canis lupus familiaris	200-211
7672622-10	1995	CONCLUSIONS: The reduction of Fe uptake by the subcultured and cataract cell lines probably reflects a decrease in transferrin receptor expression and in the activity of an alternative pathway for Fe transferrin uptake occurring over time.	Iron	197-199	inhibitor of carbonic anhydrase	Canis lupus familiaris	200-211
17962361-4	2008	Addition of Hepc to Caco-2 cells or rat duodenal segments strongly inhibited apical (55)Fe uptake without apparent effects on the transfer of (55)Fe from the cells to the basolateral medium.	Iron	88-90	hepcidin antimicrobial peptide	Homo sapiens	12-16
17962361-7	2008	Our results highlight the crucial role of Hepc in the control of intestinal iron absorption.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	42-46
18818166-1	2008	Although hepcidin, a recently discovered peptide hormone, is considered a major regulator of iron metabolism and anemia in chronic inflammation, its role in anemia during pregnancy has not been characterized.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	9-17
7720713-7	1995	FRE1 and FRE2 encode plasma membrane ferric reductases, obligatory for ferric iron assimilation, and FET3 encodes a copper-dependent membrane-associated oxidase required for ferrous iron uptake.	Iron	78-82	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	9-13
7705347-4	1995	The vacuole-lacking mutant vpt16 displayed reduced iron accumulation at high and low extracellular iron concentrations.	Iron	51-55	tethering complex subunit VPS16	Saccharomyces cerevisiae S288C	27-32
7705347-4	1995	The vacuole-lacking mutant vpt16 displayed reduced iron accumulation at high and low extracellular iron concentrations.	Iron	99-103	tethering complex subunit VPS16	Saccharomyces cerevisiae S288C	27-32
18282520-4	2008	One of these factors is hepcidin, a circulating peptide hormone that maintains iron homeostasis.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	24-32
7878679-6	1995	Western blot studies using polyclonal antibodies specifically recognizing GST 8-8 also indicated that, among the GST isozymes of rat liver, GST 8-8 was preferentially induced upon iron treatment.	Iron	180-184	glutathione S-transferase alpha 4	Rattus norvegicus	74-81
7878679-6	1995	Western blot studies using polyclonal antibodies specifically recognizing GST 8-8 also indicated that, among the GST isozymes of rat liver, GST 8-8 was preferentially induced upon iron treatment.	Iron	180-184	glutathione S-transferase alpha 4	Rattus norvegicus	140-147
18282520-5	2008	Elevated levels of hepcidin in the bloodstream effectively shut off iron absorption by disabling the iron exporter ferroportin.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	19-27
7878679-7	1995	These findings were further confirmed by purifying and quantitating GST 8-8 protein from the controls and iron-treated rats.	Iron	106-110	glutathione S-transferase alpha 4	Rattus norvegicus	68-75
7878679-8	1995	Significant differences in the specific activities of GST 8-8 purified from the controls and iron-treated rats were observed, indicating that more than one GST isozyme related to GST 8-8 may be present in rat liver.	Iron	93-97	glutathione S-transferase alpha 4	Rattus norvegicus	54-61
18282520-5	2008	Elevated levels of hepcidin in the bloodstream effectively shut off iron absorption by disabling the iron exporter ferroportin.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	19-27
7878679-8	1995	Significant differences in the specific activities of GST 8-8 purified from the controls and iron-treated rats were observed, indicating that more than one GST isozyme related to GST 8-8 may be present in rat liver.	Iron	93-97	glutathione S-transferase alpha 4	Rattus norvegicus	179-186
18282520-6	2008	Conversely, low levels of circulating hepcidin allow ferroportin to export iron into the bloodstream.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	38-46
18282520-7	2008	Aberrations in hepcidin expression or responsiveness to hepcidin result in disorders of iron deficiency and iron overload.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	15-23
18282520-7	2008	Aberrations in hepcidin expression or responsiveness to hepcidin result in disorders of iron deficiency and iron overload.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	56-64
18282520-8	2008	It is clear that erythroid precursors communicate their iron needs to the liver to influence the production of hepcidin and thus the amount of iron available for use.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	111-119
7757018-7	1995	The long range of paramagnetic shift effects (up to 20 A from the iron in the case of cytochrome c) provides global structural constraints, which, in conjunction with conventional NMR distance and dihedral angle constraints, will enhance the precision of NMR solution structure determination.	Iron	66-70	cytochrome c, somatic	Equus caballus	86-98
18078992-2	2008	The mammalian IntL is also known as lactoferrin receptor (LfR) that is involved in iron metabolism.	Iron	83-87	intelectin 1	Homo sapiens	36-56
18078992-2	2008	The mammalian IntL is also known as lactoferrin receptor (LfR) that is involved in iron metabolism.	Iron	83-87	intelectin 1	Homo sapiens	58-61
7756113-0	1995	Binding and iron delivering of ovotransferrin to cholesterol-depleted chick-embryo red blood cells.	Iron	12-16	transferrin (ovotransferrin)	Gallus gallus	31-45
7756113-9	1995	It is suggested that cholesterol may tune binding and iron uptake by either regulating or affecting the expression or mobility of the OTf receptor.	Iron	54-58	transferrin (ovotransferrin)	Gallus gallus	134-137
18166363-0	2008	HCV, iron, and oxidative stress: the new choreography of hepcidin.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	57-65
7982480-6	1994	High affinity copper uptake mediated by the copper transport protein encoded by CTR1 is required to provide the FET3 protein with copper, and thus copper uptake is indirectly required for ferrous iron uptake.	Iron	188-200	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	80-84
18316319-3	2008	The expression of genes involved in the mobilization of iron (CsHA1), the reduction of ferric chelates (CsFRO1), and in the uptake of ferrous iron (CsIRT1) was investigated in epidermal cells of Fe-sufficient and Fe-deficient cucumber (Cucumis sativum L.) roots using the Laser Microdissection and Pressure Catapulting (LMPC) method.	Iron	56-60	plasma membrane ATPase 4	Cucumis sativus	62-67
7947682-7	1994	Given the similarities in iron-binding properties, it was investigated whether Fbp bound iron by a similar molecular strategy as the transferrins.	Iron	89-93	folate receptor beta	Homo sapiens	79-82
7947682-9	1994	Chemical modification of purified Fbp in the presence and absence of iron using the Tyr-specific modifier tetranitromethane demonstrates that between two and three Tyr residues are implicated in iron binding.	Iron	195-199	folate receptor beta	Homo sapiens	34-37
7947682-10	1994	A similar experiment using the His-specific reagent diethyl pyrocarbonate indicates that one of the six Fbp-encoded His residues is protected by iron.	Iron	145-149	folate receptor beta	Homo sapiens	104-107
7947682-11	1994	In addition, like the transferrins, a bicarbonate anion is required for the efficient coordination of iron by Fbp.	Iron	102-106	folate receptor beta	Homo sapiens	110-113
18316319-6	2008	The formation of root hairs in response to Fe starvation was associated with a dramatic increase in message levels of CsFRO1, CsIRT1, and the iron-inducible H(+)-ATPase isoform CsHA1, when compared to epidermal cells of Fe-sufficient plants.	Iron	43-45	plasma membrane ATPase 4	Cucumis sativus	177-182
7947682-14	1994	These studies suggest that the prokaryotic Fbp is a mono-sited analog for iron binding by the eukaryotic transferrins.	Iron	74-78	folate receptor beta	Homo sapiens	43-46
18316319-7	2008	On the contrary, transcripts of a housekeeping ATPase isoform, CsHA2, were not detected in root hairs, suggesting that Fe-deficiency-induced acidification is predominantly mediated by CsHA1.	Iron	119-121	plasma membrane ATPase 4	Cucumis sativus	184-189
18188710-6	2008	Some inhibitory cytokines, such as tumour necrosis factor-alpha and interleukin-1, act on the suppression of erythroid precursor cells and erythropoietic production and response; others, such as interleukins 1 and 6 and hepcidin, impair iron metabolism, causing iron to be diverted from erythropoiesis and retained within the reticuloendothelial system.	Iron	237-241	interleukin 1 alpha	Homo sapiens	68-81
7945364-1	1994	The objective of this investigation was to determine whether myoglobin can serve as a physiological source of iron in the catalysis of Adriamycin-stimulated lipid peroxidation.	Iron	110-114	myoglobin	Homo sapiens	61-70
18188710-6	2008	Some inhibitory cytokines, such as tumour necrosis factor-alpha and interleukin-1, act on the suppression of erythroid precursor cells and erythropoietic production and response; others, such as interleukins 1 and 6 and hepcidin, impair iron metabolism, causing iron to be diverted from erythropoiesis and retained within the reticuloendothelial system.	Iron	262-266	interleukin 1 alpha	Homo sapiens	68-81
8074229-1	1994	The role of human lactoferrin (hLf) in alimentary iron absorption across intestinal cells was explored using a human differentiated colon carcinoma cell line, HT-29cl.19A.	Iron	50-54	HLF transcription factor, PAR bZIP family member	Homo sapiens	31-34
17471497-10	2007	A possible link between iron status and two additional transcription factors, that is, CREB and Egr-1, rather than NF-kappaB, was also suggested.	Iron	24-28	early growth response 1	Homo sapiens	96-101
8007965-2	1994	To determine if c-fps/fes can mediate the action of the colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) and to identify potential targets of c-fps/fes in macrophages, we have overexpressed c-fps/fes in a CSF-1-dependent macrophage cell line.	Iron	22-25	colony stimulating factor 1	Homo sapiens	56-83
8007965-2	1994	To determine if c-fps/fes can mediate the action of the colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) and to identify potential targets of c-fps/fes in macrophages, we have overexpressed c-fps/fes in a CSF-1-dependent macrophage cell line.	Iron	22-25	colony stimulating factor 1	Homo sapiens	85-90
17516501-6	2007	The findings also showed that both the development and iron status have a significant effect on Heph expression and the effects of iron status are regionally specific.	Iron	55-59	hephaestin	Rattus norvegicus	96-100
8188179-3	1994	Whether diferric or iron free, lactoferrin peaked in the bile 35 min after administration (i.e., the same time as bovine lactoperoxidase and diferric rat transferrin).	Iron	20-24	lactotransferrin	Bos taurus	31-42
17516501-7	2007	It was also suggested that Heph expression is probably regulated at the transcriptional level by the development and iron in these brain regions.	Iron	117-121	hephaestin	Rattus norvegicus	27-31
17516501-8	2007	These findings, together with other published data, support a putative role of Heph in the iron metabolism in the brain.	Iron	91-95	hephaestin	Rattus norvegicus	79-83
7938909-6	1994	Furthermore, reduction of Fe and Zn contents in the liver of the PBC patients indicated the possible relationship of ceruloplasmin to Fe and Zn metabolism as well as Cu metabolism.	Iron	26-28	ceruloplasmin	Homo sapiens	117-130
7938909-6	1994	Furthermore, reduction of Fe and Zn contents in the liver of the PBC patients indicated the possible relationship of ceruloplasmin to Fe and Zn metabolism as well as Cu metabolism.	Iron	134-136	ceruloplasmin	Homo sapiens	117-130
17953660-14	2007	They probably to export iron by a mechanism involving a membrane-bound form of the ferroxidase, ceruloplasmin.	Iron	24-28	ceruloplasmin	Homo sapiens	96-109
7951057-0	1994	Xanthine oxidase: an efficient promoter of the iron loading of apoferritin.	Iron	47-51	ferritin heavy chain 1	Homo sapiens	63-74
7951057-2	1994	These studies demonstrate that xanthine oxidase also efficiently promotes the oxidative incorporation of iron into apoferritin, the major iron storage protein of vertebrates, and that the ferroxidase activity of intestinal xanthine oxidase could be important in determining the fraction of iron within the intestinal mucosa cell partitioned to ferritin versus the iron that remains in a transient pool for rapid transport to plasma.	Iron	105-109	ferritin heavy chain 1	Homo sapiens	115-126
18079564-2	2007	The pathophysiology of this error in iron metabolism is not completely elucidated yet, although deficiency of the iron regulatory hormone hepcidin appears to play a role.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	138-146
7951057-2	1994	These studies demonstrate that xanthine oxidase also efficiently promotes the oxidative incorporation of iron into apoferritin, the major iron storage protein of vertebrates, and that the ferroxidase activity of intestinal xanthine oxidase could be important in determining the fraction of iron within the intestinal mucosa cell partitioned to ferritin versus the iron that remains in a transient pool for rapid transport to plasma.	Iron	138-142	ferritin heavy chain 1	Homo sapiens	115-126
7951057-2	1994	These studies demonstrate that xanthine oxidase also efficiently promotes the oxidative incorporation of iron into apoferritin, the major iron storage protein of vertebrates, and that the ferroxidase activity of intestinal xanthine oxidase could be important in determining the fraction of iron within the intestinal mucosa cell partitioned to ferritin versus the iron that remains in a transient pool for rapid transport to plasma.	Iron	138-142	ferritin heavy chain 1	Homo sapiens	115-126
7951057-2	1994	These studies demonstrate that xanthine oxidase also efficiently promotes the oxidative incorporation of iron into apoferritin, the major iron storage protein of vertebrates, and that the ferroxidase activity of intestinal xanthine oxidase could be important in determining the fraction of iron within the intestinal mucosa cell partitioned to ferritin versus the iron that remains in a transient pool for rapid transport to plasma.	Iron	138-142	ferritin heavy chain 1	Homo sapiens	115-126
17904862-1	2007	Ferritin is a class of iron storage protein composed of 24 subunits.	Iron	23-27	ferritin-1, chloroplastic	Glycine max	0-8
8142485-7	1994	(C) The removal of iron leads to thermal destabilization of HST, HLF and RST.	Iron	19-23	HLF transcription factor, PAR bZIP family member	Homo sapiens	65-68
17904862-5	2007	We conclude that certain combinations of plant ferritin subunits can form heteropolymers and that their iron incorporating activities depend on the formation of multimeric protein.	Iron	104-108	ferritin-1, chloroplastic	Glycine max	47-55
17948991-4	2007	Reaction of 4 with 1 equiv of Ag(PPh3)OTf gives the mononuclear chelate complex [Ag(OTf)PPh3{Fe(C5H4PR)2-kappaP,kappaP}] (11), whereas treatment with 2 equiv of AuCl(SMe2) produces the dinuclear gold complex [Au(Cl){Fe(C5H4PR)2-kappaP,kappaP}Au(Cl)] (12).	Iron	93-95	protein phosphatase 4 catalytic subunit	Homo sapiens	88-92
17958355-12	2007	The plot of log (kO2) versus energy of the low-energy DBC2--to-iron(III) LMCT band is linear, demonstrating the importance of the Lewis acidity of the iron(III) center in dictating the rate of the dioxygenase reaction.	Iron	63-67	Rho related BTB domain containing 2	Homo sapiens	54-58
8175108-4	1994	The highest correlation was found between S-ferritin and the product of chemical iron x ASAT (r = 0.61, p = 0.0001) (log vs. log values).	Iron	81-85	ATP binding cassette subfamily B member 7	Homo sapiens	88-92
17958355-12	2007	The plot of log (kO2) versus energy of the low-energy DBC2--to-iron(III) LMCT band is linear, demonstrating the importance of the Lewis acidity of the iron(III) center in dictating the rate of the dioxygenase reaction.	Iron	151-155	Rho related BTB domain containing 2	Homo sapiens	54-58
17996046-7	2007	Amino acid conservation patterns support this hypothesis and indicate that both 2-oxoglutarate and iron should be important for FTO function.	Iron	99-103	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	128-131
7710263-1	1994	In calves with severe iron (Fe) deficiency, insulin-like growth factor (IGF)-I levels and IGF-I responses to exogenous growth hormone (GH) are reduced, while insulin-dependent glucose utilization is enhanced.	Iron	22-26	insulin	Bos taurus	44-51
7710263-1	1994	In calves with severe iron (Fe) deficiency, insulin-like growth factor (IGF)-I levels and IGF-I responses to exogenous growth hormone (GH) are reduced, while insulin-dependent glucose utilization is enhanced.	Iron	28-30	insulin	Bos taurus	44-51
7880888-4	1994	The lipid-induced perturbations in the structure of cytochrome c involve: i) conformational changes in and around the heme crevice, converting the heme iron to a high-spin state: and ii) a destabilisation/loosening of the overall tertiary and secondary structure.	Iron	152-156	cytochrome c, somatic	Equus caballus	52-64
17907198-4	2007	Zebrafish carrying transgenes under the control of a heat shock promoter (hsp70) are focally heated with the soldering iron to induce gene expression in a small area of the embryo.	Iron	119-123	heat shock protein 8-like	Danio rerio	74-79
27315707-0	1994	Suppressive Effects of Lactoferrin on Bleomycin-dependent DNA Damage by the Iron Ion and Ascorbate.	Iron	76-80	lactotransferrin	Bos taurus	23-34
17822515-6	2007	This article discusses three cellular regulators (p53, p21 and TRAIL) induced in synovial tissue that are important for iron metabolism.	Iron	120-124	H3 histone pseudogene 16	Homo sapiens	55-58
8011525-10	1994	Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable animal model of spontaneous iron-overload.	Iron	86-90	hemopexin	Mus musculus	27-30
8011525-10	1994	Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable animal model of spontaneous iron-overload.	Iron	86-90	hemopexin	Mus musculus	31-34
8011525-10	1994	Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable animal model of spontaneous iron-overload.	Iron	110-114	hemopexin	Mus musculus	27-30
17804076-2	2007	Iron deposition into horse spleen ferritin (HoSF) occurs using ferricyanide ion, 2,6-dichlorophenol-indophenol, and several redox proteins: cytochrome c, stellacyanin, and ceruloplasmin.	Iron	0-4	cytochrome c, somatic	Equus caballus	140-152
8011525-10	1994	Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable animal model of spontaneous iron-overload.	Iron	110-114	hemopexin	Mus musculus	31-34
8011525-10	1994	Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable animal model of spontaneous iron-overload.	Iron	110-114	hemopexin	Mus musculus	27-30
8011525-10	1994	Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable animal model of spontaneous iron-overload.	Iron	110-114	hemopexin	Mus musculus	31-34
17660359-0	2007	FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii.	Iron	145-149	uncharacterized protein	Chlamydomonas reinhardtii	0-4
17660359-0	2007	FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii.	Iron	145-149	uncharacterized protein	Chlamydomonas reinhardtii	16-20
17660359-2	2007	In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replete cells.	Iron	206-210	uncharacterized protein	Chlamydomonas reinhardtii	83-87
8257710-1	1993	We characterized endocytosis of iron-saturated (holo) and iron-depleted (apo) 125I-labeled bovine lactoferrin (Lf) by isolated rat hepatocytes.	Iron	58-62	lactotransferrin	Bos taurus	98-109
17660359-2	2007	In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replete cells.	Iron	228-232	uncharacterized protein	Chlamydomonas reinhardtii	83-87
17660359-3	2007	In a parallel proteomic approach, we identified FEA1 and FEA2 as the major proteins secreted by iron-deficient Chlamydomonas reinhardtii.	Iron	96-100	uncharacterized protein	Chlamydomonas reinhardtii	48-52
17660359-4	2007	The recovery of FEA1 and FEA2 from the medium of Chlamydomonas strain CC425 cultures is strictly correlated with iron nutrition status, and the accumulation of the corresponding mRNAs parallels that of the Chlamydomonas FOX1 and FTR1 mRNAs, although the magnitude of regulation is more dramatic for the FEA genes.	Iron	113-117	uncharacterized protein	Chlamydomonas reinhardtii	16-20
8244935-0	1993	Cloning and characterization of the Pseudomonas aeruginosa sodA and sodB genes encoding manganese- and iron-cofactored superoxide dismutase: demonstration of increased manganese superoxide dismutase activity in alginate-producing bacteria.	Iron	103-107	superoxide dismutase	Pseudomonas aeruginosa PAO1	68-72
8244935-6	1993	In this study, the genes encoding manganese (sodA)- and iron (sodB)- cofactored superoxide dismutase were cloned by using a cosmid library of P. aeruginosa FRD which complemented an Escherichia coli (JI132) strain devoid of superoxide dismutase activity.	Iron	56-60	superoxide dismutase	Pseudomonas aeruginosa PAO1	62-66
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	83-87	uncharacterized protein	Chlamydomonas reinhardtii	49-53
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	49-53
17620357-1	2007	Solute carrier family 11 member a1 (Slc11a1; formerly Nramp1) encodes a late endosomal/lysosomal protein/divalent cation transporter that regulates iron homeostasis in macrophages.	Iron	148-152	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	36-43
17620357-1	2007	Solute carrier family 11 member a1 (Slc11a1; formerly Nramp1) encodes a late endosomal/lysosomal protein/divalent cation transporter that regulates iron homeostasis in macrophages.	Iron	148-152	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	54-60
8132877-13	1993	Thus, UHT seems to affect structural as well as certain biological properties of both native and iron-saturated bovine lactoferrins, and pasteurization seems to be a treatment of choice for products containing this protein.	Iron	97-101	UHT	Bos taurus	6-9
18044280-1	2007	INTRODUCTION: Heme-Oxygenase-1 catalyzes hemoglobin into bilirubin, iron, and carbon monoxide, a well known vasodilator.	Iron	68-72	heme oxygenase 1	Homo sapiens	14-30
8405449-5	1993	Based on the MCD spectra of reduced cytochrome and the optical absorption spectra in the visible region of the oxidized cytochrome, it is suggested that the heme iron in cytochrome b560 has two histidine imidazoles as the 5th and 6th axial ligands.	Iron	162-166	CYTB	Coregonus lavaretus	170-182
17767550-4	2007	The aim of this study was to assess MCP-1 levels in patients with HH and correlate these results with HFE status and iron indexes.	Iron	117-121	C-C motif chemokine ligand 2	Homo sapiens	36-41
8374212-3	1993	Iron-saturated lactoferrin increased DNA synthesis of neonatal hepatocytes by 1.5 times and this potency was the same as that of insulin.	Iron	0-4	lactotransferrin	Rattus norvegicus	15-26
8374212-5	1993	Iron-free lactoferrin did not affect DNA synthesis, nor did the exogenous addition of ferric ions.	Iron	0-4	lactotransferrin	Rattus norvegicus	10-21
8374212-7	1993	These results suggest that iron-saturated lactoferrin, which itself had low mitogenic activity, is a co-mitogenic substance for neonatal hepatocytes in vitro.	Iron	27-31	lactotransferrin	Rattus norvegicus	42-53
17767550-11	2007	This study suggests for the first time that a differential expression of MCP-1 protein in patients with HH is associated with the specific HFE genetic component for iron overload.	Iron	165-169	C-C motif chemokine ligand 2	Homo sapiens	73-78
17727827-1	2007	Ceruloplasmin (Cp) is the major copper transport protein in plasma and catalyzes the conversion of toxic ferrous iron to the safer ferric iron.	Iron	105-117	ceruloplasmin	Mus musculus	0-13
8237180-3	1993	The ADG and feed utilization as well as haemoglobin and the plasma iron concentration were positively influenced by iron intake (P &lt; or = 0.05).	Iron	116-120	ADG	Bos taurus	4-7
17434931-4	2007	Here, we demonstrate that ferritin heavy chain (FHC), a core subunit of iron-binding protein ferritin, works as an anti-apoptotic protein against toxic asbestos and oxidative stress in human mesothelial cells and MM cells.	Iron	72-76	ferritin heavy chain 1	Homo sapiens	26-46
12231882-6	1993	Competition for nutritional iron was also studied through a plant-bacterial cell system: iron incorporated into plant ferritin appeared to be considerably reduced in bacteria-treated suspension soybean cells.	Iron	28-32	ferritin-1, chloroplastic	Glycine max	118-126
12231882-6	1993	Competition for nutritional iron was also studied through a plant-bacterial cell system: iron incorporated into plant ferritin appeared to be considerably reduced in bacteria-treated suspension soybean cells.	Iron	89-93	ferritin-1, chloroplastic	Glycine max	118-126
7763874-2	1993	To learn the mechanism of action of an iron-binding protein, lactoferrin (Lf), on cultured animal cells, we have examined the effects of bovine Lf (bLf) on NGF synthesis/secretion in mouse L-M cells, a line derived from L929 fibroblast cells.	Iron	39-43	lactotransferrin	Bos taurus	61-72
7763874-2	1993	To learn the mechanism of action of an iron-binding protein, lactoferrin (Lf), on cultured animal cells, we have examined the effects of bovine Lf (bLf) on NGF synthesis/secretion in mouse L-M cells, a line derived from L929 fibroblast cells.	Iron	39-43	lactotransferrin	Bos taurus	74-76
17434931-4	2007	Here, we demonstrate that ferritin heavy chain (FHC), a core subunit of iron-binding protein ferritin, works as an anti-apoptotic protein against toxic asbestos and oxidative stress in human mesothelial cells and MM cells.	Iron	72-76	ferritin heavy chain 1	Homo sapiens	48-51
17726138-0	2007	Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer.	Iron	23-27	heme oxygenase 1	Homo sapiens	85-89
8389149-3	1993	The data on paramagnetic relaxation of acetanilide protons in the presence of P-450 have shown the structure of the enzyme-substrate complex to be different for two isozymes, acetanilide molecule being closer to Fe ion in the active site in the case of P-450c, which is active towards acetanilide oxidation.	Iron	212-214	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	253-259
8389149-4	1993	For the P-450c-acetanilide complex the group oxidized (phenyl) is the closest to Fe ion.	Iron	81-83	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	8-14
17710675-3	2007	MATERIAL AND METHODS: Here, we report the identification, clinical characterization, and in silico analysis of a novel compound heterozygosity in the ceruloplasmin gene of a 31-year-old man with iron overload.	Iron	195-199	ceruloplasmin	Homo sapiens	150-163
8386158-0	1993	The mitochondrial targeting presequence of the Rieske iron-sulfur protein is processed in a single step after insertion into the cytochrome bc1 complex in mammals and retained as a subunit in the complex.	Iron	54-58	brain cytoplasmic RNA 1	Rattus norvegicus	140-143
17485548-4	2007	We report the first case of GLRX5 deficiency in a middle-aged anemic male with iron overload and a low number of ringed sideroblasts.	Iron	79-83	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	28-33
8449958-3	1993	The previous identification of iron-responsive elements in the 5"-untranslated region of human and murine erythroid ALAS mRNA raised the intriguing possibility that eALAS expression might be under iron-dependent translational control.	Iron	31-35	aminolevulinic acid synthase 1	Mus musculus	116-120
8492301-8	1993	Oxygen consumption studies of ceruloplasmin catalyzed epinephrine oxidation showed that copper was a better promoter of epinephrine oxidation than was iron, suggesting that ceruloplasmin-catalyzed epinephrine oxidation results from adventitious copper bound to the purified enzyme.	Iron	151-155	ceruloplasmin	Homo sapiens	173-186
17485548-10	2007	GLRX5 function is highly conserved, but at variance with zebrafish, its defect in humans leads to anemia and iron overload.	Iron	109-113	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	0-5
17435114-1	2007	The hepatic peptide hormone hepcidin is considered the central regulator of iron metabolism.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	28-36
8440323-11	1993	It therefore appears that synthesis of p34cdc2 requires a low amount of iron, a finding which may define a possible regulatory point in the cell cycle for iron before its well-recognized role in regulating S phase entry by acting as a cofactor for the enzyme ribonucleotide reductase.	Iron	72-76	cyclin dependent kinase 1	Homo sapiens	39-46
8440323-11	1993	It therefore appears that synthesis of p34cdc2 requires a low amount of iron, a finding which may define a possible regulatory point in the cell cycle for iron before its well-recognized role in regulating S phase entry by acting as a cofactor for the enzyme ribonucleotide reductase.	Iron	155-159	cyclin dependent kinase 1	Homo sapiens	39-46
8443348-4	1993	A precursor/product relationship between iron stored in ferritin and iron in nitrogenase or leghemoglobin is suggested.	Iron	41-45	ferritin-1, chloroplastic	Glycine max	56-64
17293845-5	2007	Most interestingly, AR(-/-) brains showed lowered expression of transferrin and transferrin receptor with less iron deposition and nitrotyrosine accumulation.	Iron	111-115	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	20-22
8380334-1	1993	Histidine-93(F8) in human myoglobin (Mb), which is the proximal ligand of the heme iron, has been replaced with cysteine or tyrosine by site-directed mutagenesis.	Iron	83-87	myoglobin	Homo sapiens	26-35
17293845-8	2007	These findings are the first to show that AR contributes to iron- and transferrin-related oxidative stress associated with cerebral ischemic injury, suggesting that inhibition of AR but not SD may have therapeutic potential against cerebral ischemic injury.	Iron	60-64	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	42-44
17293845-8	2007	These findings are the first to show that AR contributes to iron- and transferrin-related oxidative stress associated with cerebral ischemic injury, suggesting that inhibition of AR but not SD may have therapeutic potential against cerebral ischemic injury.	Iron	60-64	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	179-181
8018447-9	1993	IL-1 reduced zinc and iron plasma levels and elevated copper plasma levels.	Iron	22-26	interleukin 1 alpha	Homo sapiens	0-4
17538022-4	2007	Msn5p recognizes Aft1p in the iron-replete condition.	Iron	30-34	karyopherin MSN5	Saccharomyces cerevisiae S288C	0-5
1463463-6	1992	Competition experiments at pH 5.5 demonstrated that L-chain apoferritin is able to incorporate iron only when in the presence of H-chain variants with ferroxidase activity.	Iron	95-99	ferritin heavy chain 1	Homo sapiens	60-71
1463463-7	1992	The results indicate that L-chain apoferritin has a higher capacity than the H-chain apoferritin to induce iron-core nucleation, whereas H-chain ferritin is superior in promoting Fe(II) oxidation.	Iron	107-111	ferritin heavy chain 1	Homo sapiens	34-45
1463463-7	1992	The results indicate that L-chain apoferritin has a higher capacity than the H-chain apoferritin to induce iron-core nucleation, whereas H-chain ferritin is superior in promoting Fe(II) oxidation.	Iron	107-111	ferritin heavy chain 1	Homo sapiens	85-96
1452033-6	1992	Furthermore, re-hLF is functional by the criterion of iron-binding capacity.	Iron	54-58	HLF transcription factor, PAR bZIP family member	Homo sapiens	16-19
17656326-6	2007	The yeast protein Atm1p plays a critical role in the transport of Fe/S clusters to the cytosol, and a similar function has been attributed to the homologous human proteins MTABC3 and ABC7.	Iron	66-68	ATP binding cassette subfamily B member 7	Homo sapiens	183-187
1492102-5	1992	Studies utilizing indomethacin (a selective cyclooxygenase inhibitor) and desferrioxamine (an iron-chelating agent) revealed that the inhibitory effect of t-BOOH on the lipoxygenase is not mediated through the activation of the cyclooxygenase and that this effect of t-BOOH is due to the hydroperoxy moiety.	Iron	94-98	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	169-181
17428703-7	2007	Experiments of in vitro iron loading or iron deprivation provided evidence that TfR2 is modulated in cancer cell lines according to cellular iron levels following two different mechanisms: (i) in some cells, iron loading caused a downmodulation of total TfR2 levels; (ii) in other cell types, iron loading caused a downmodulation of membrane-bound TfR2, without affecting the levels of total cellular TfR2 content.	Iron	40-44	transferrin receptor 2	Homo sapiens	80-84
1429633-0	1992	Coordination structure of the ferric heme iron in engineered distal histidine myoglobin mutants.	Iron	42-46	myoglobin	Homo sapiens	78-87
1429633-2	1992	Electronic and coordination structures of the ferric heme iron in the recombinant myoglobin proteins were examined by optical absorption, EPR, 1H NMR, magnetic circular dichroism, and x-ray spectroscopy.	Iron	58-62	myoglobin	Homo sapiens	82-91
17428703-10	2007	Furthermore, our studies indicate that, at least in tumor cells, TfR2 expression is modulated by iron through different biochemical mechanisms, whose molecular basis remains to be determined.	Iron	97-101	transferrin receptor 2	Homo sapiens	65-69
10002979-0	1992	Non-Markovian relaxation observed in photon echoes of iron-free myoglobin.	Iron	54-58	myoglobin	Homo sapiens	64-73
17446262-7	2007	The major effects of cyt b5 are hypothesized to result from a cyt b5-induced conformational change in CYP2C9 that results in an increased collision frequency between the iron-oxygen species (Cpd I) and the substrate, and a decrease in the oxidase activity.	Iron	170-174	cytochrome b5 type A	Homo sapiens	21-27
1524426-0	1992	Ribosomal protein P2, a novel iron-binding protein.	Iron	30-34	ribosomal protein lateral stalk subunit P2	Rattus norvegicus	0-20
1524426-8	1992	Immunoblot analysis and iron-binding assay confirmed that the iron-binding protein and ribosomal protein P2 are identical.	Iron	24-28	ribosomal protein lateral stalk subunit P2	Rattus norvegicus	87-107
1524426-9	1992	Then the iron binding ability of ribosomal protein P2 was examined in rat hepatoma H4IIEC3 cells incubated with radioactive iron.	Iron	9-13	ribosomal protein lateral stalk subunit P2	Rattus norvegicus	33-53
1524426-9	1992	Then the iron binding ability of ribosomal protein P2 was examined in rat hepatoma H4IIEC3 cells incubated with radioactive iron.	Iron	124-128	ribosomal protein lateral stalk subunit P2	Rattus norvegicus	33-53
17446262-7	2007	The major effects of cyt b5 are hypothesized to result from a cyt b5-induced conformational change in CYP2C9 that results in an increased collision frequency between the iron-oxygen species (Cpd I) and the substrate, and a decrease in the oxidase activity.	Iron	170-174	cytochrome b5 type A	Homo sapiens	62-68
17446262-7	2007	The major effects of cyt b5 are hypothesized to result from a cyt b5-induced conformational change in CYP2C9 that results in an increased collision frequency between the iron-oxygen species (Cpd I) and the substrate, and a decrease in the oxidase activity.	Iron	170-174	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	102-108
1633859-3	1992	The most significant amino acid substitutions in p97 are almost exclusively limited to only two regions; the C-lobe iron-binding cleft and the interlobe contact region.	Iron	116-120	melanotransferrin	Homo sapiens	49-52
17455153-0	2007	The role of hepcidin and ferroportin in iron absorption.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	12-20
1582942-0	1992	A comparative physiological and behavioral study of freeze and hot-iron branding using dairy cows.	Iron	67-71	alcohol dehydrogenase iron containing 1	Bos taurus	63-66
1582942-1	1992	A public debate has recently arisen, largely surrounding the issue of pain, over whether freeze or hot-iron branding should be the preferred method of permanently identifying cattle.	Iron	103-107	alcohol dehydrogenase iron containing 1	Bos taurus	99-102
1582942-9	1992	Because the cows exhibited a greater escape-avoidance reaction and heart rate proportions to hot-iron branding, freeze banding would be preferable to hot-iron branding when feasible.	Iron	97-101	alcohol dehydrogenase iron containing 1	Bos taurus	93-96
17557118-2	2007	Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron absorption and homeostasis in mammals.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	0-8
1547222-0	1992	The iron regulatory region of ferritin mRNA is also a positive control element for iron-independent translation.	Iron	4-8	ferritin-1, chloroplastic	Glycine max	30-38
1547222-0	1992	The iron regulatory region of ferritin mRNA is also a positive control element for iron-independent translation.	Iron	83-87	ferritin-1, chloroplastic	Glycine max	30-38
17557118-3	2007	Hepcidin production is increased by iron overload and decreased by anemia and hypoxia; but the molecular mechanisms that govern the hepcidin response to these stimuli are not known.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
1547222-1	1992	The iron regulatory element (IRE) in the 5"-untranslated region of ferritin mRNA interacts with a specific regulator protein (P-90, IRE-BP, or FRP) to block translation.	Iron	4-8	ferritin-1, chloroplastic	Glycine max	67-75
17557118-4	2007	Here we establish that the von Hippel-Lindau/hypoxia-inducible transcription factor (VHL/HIF) pathway is an essential link between iron homeostasis and hepcidin regulation in vivo.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	152-160
17557118-5	2007	Through coordinate downregulation of hepcidin and upregulation of erythropoietin and ferroportin, the VHL-HIF pathway mobilizes iron to support erythrocyte production.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	37-45
1544447-0	1992	Human melanotransferrin (p97) has only one functional iron-binding site.	Iron	54-58	melanotransferrin	Homo sapiens	6-23
1544447-0	1992	Human melanotransferrin (p97) has only one functional iron-binding site.	Iron	54-58	melanotransferrin	Homo sapiens	25-28
17475779-2	2007	Hepcidin, a peptide secreted by the liver in response to iron or inflammation, binds to Fpn, inducing its internalization and degradation.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
1544447-1	1992	The iron-binding properties of melanotransferrin, the tumour-associated antigen also known as p97, have been investigated by UV/visible and fluorescence spectroscopy, amino acid sequence comparison, and modelling.	Iron	4-8	melanotransferrin	Homo sapiens	31-48
1544447-1	1992	The iron-binding properties of melanotransferrin, the tumour-associated antigen also known as p97, have been investigated by UV/visible and fluorescence spectroscopy, amino acid sequence comparison, and modelling.	Iron	4-8	melanotransferrin	Homo sapiens	94-97
1543713-2	1992	Exposure of melanoma cells to DFO increased membrane non-Tf-bound Fe uptake (putative melanotransferrin Fe-binding sites), suggesting upregulation of the membrane Fe-binding component.	Iron	66-68	melanotransferrin	Homo sapiens	86-103
1543713-2	1992	Exposure of melanoma cells to DFO increased membrane non-Tf-bound Fe uptake (putative melanotransferrin Fe-binding sites), suggesting upregulation of the membrane Fe-binding component.	Iron	104-106	melanotransferrin	Homo sapiens	86-103
1543713-2	1992	Exposure of melanoma cells to DFO increased membrane non-Tf-bound Fe uptake (putative melanotransferrin Fe-binding sites), suggesting upregulation of the membrane Fe-binding component.	Iron	104-106	melanotransferrin	Homo sapiens	86-103
1728313-2	1992	Both dimethyl-3-hydroxypyridin-4-one (CP 20 or L1) and diethyl-3-hydroxypyridine-4-one (CP 94) have an identical and very high (log beta 3 36) binding constant and selective affinity to iron(III), but the lipid solubility of CP 94 is considerably higher than that of CP 20.	Iron	186-190	beaded filament structural protein 1	Rattus norvegicus	88-93
17613881-8	2007	Association between cord blood prohepcidin and MCHC may suggest a possible link between hepcidin and fetal iron homeostasis.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	34-42
1295714-4	1992	Inadequate iron supply of the bone marrow in the presence of sufficient storage iron in the RES develops frequently under rEPO, possibly explaining the improvement of bone marrow response to rEPO by concomitant intravenous iron supply.	Iron	11-15	erythropoietin	Rattus norvegicus	122-126
1295714-4	1992	Inadequate iron supply of the bone marrow in the presence of sufficient storage iron in the RES develops frequently under rEPO, possibly explaining the improvement of bone marrow response to rEPO by concomitant intravenous iron supply.	Iron	11-15	erythropoietin	Rattus norvegicus	191-195
1295714-4	1992	Inadequate iron supply of the bone marrow in the presence of sufficient storage iron in the RES develops frequently under rEPO, possibly explaining the improvement of bone marrow response to rEPO by concomitant intravenous iron supply.	Iron	80-84	erythropoietin	Rattus norvegicus	122-126
1295714-4	1992	Inadequate iron supply of the bone marrow in the presence of sufficient storage iron in the RES develops frequently under rEPO, possibly explaining the improvement of bone marrow response to rEPO by concomitant intravenous iron supply.	Iron	80-84	erythropoietin	Rattus norvegicus	122-126
17489602-2	2007	Lactoferrin is a globular multifunctional protein that has been shown to play a role in iron absorption and to have antimicrobial and anti-inflammatory activities.	Iron	88-92	lactotransferrin	Mus musculus	0-11
1608302-5	1992	ALDH was more susceptible than G6Pase to inactivation by iron and ascorbate, and was thus an excellent marker for oxidative stress.	Iron	57-61	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	31-37
1342713-4	1992	With the mounting evidence that TNF, IL-1, and T lymphocyte cytokines affect hemopoiesis and iron metabolism it is possible that the reported discrepancy is a reflection of that inextricable interdependence between the two systems in the face of infection.	Iron	93-97	interleukin 1 alpha	Homo sapiens	37-41
17540900-2	2007	Data from experiments performed on iron-sulfur and iron-nickel-sulfur systems at pressures corresponding to the center of Mars indicate that its core is presently completely liquid and that it will not form an outwardly crystallizing iron-rich inner core, as does Earth.	Iron	35-39	methionyl-tRNA synthetase 1	Homo sapiens	122-126
17540900-2	2007	Data from experiments performed on iron-sulfur and iron-nickel-sulfur systems at pressures corresponding to the center of Mars indicate that its core is presently completely liquid and that it will not form an outwardly crystallizing iron-rich inner core, as does Earth.	Iron	51-55	methionyl-tRNA synthetase 1	Homo sapiens	122-126
1514043-5	1992	Iron depletion also resulted in decreased production of interleukin 2 (IL-2) in the proliferating cells.	Iron	0-4	interleukin 2	Mus musculus	56-69
1514043-5	1992	Iron depletion also resulted in decreased production of interleukin 2 (IL-2) in the proliferating cells.	Iron	0-4	interleukin 2	Mus musculus	71-75
17540900-2	2007	Data from experiments performed on iron-sulfur and iron-nickel-sulfur systems at pressures corresponding to the center of Mars indicate that its core is presently completely liquid and that it will not form an outwardly crystallizing iron-rich inner core, as does Earth.	Iron	51-55	methionyl-tRNA synthetase 1	Homo sapiens	122-126
17557664-13	2007	Deficiency of hepcidin, an important regulator for the iron metabolism, was suspected in our patient, based on the early onset of his disease and the low serum levels of hepcidin.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	14-22
17557668-4	2007	Hepcidin is a small protein that regulates the activity of the iron exporting protein ferroportin in the basolateral membrane of duodenal cells and the cell membrane of macrophages and thereby controls serum iron concentration.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
1757616-3	1991	Heat-treated lactoferrin, treated at pH 2.0 and 120 degrees C for 15 min and degree of hydrolysis of about 10%, had no Fe-binding capacity (0%) and less antigenicity (about 10(-6) than untreated lactoferrin.	Iron	119-121	lactotransferrin	Bos taurus	13-24
1757616-4	1991	Heat-treated lactoferrin increased in antibacterial activity, and the activity was maintained in an Fe-rich medium.	Iron	100-102	lactotransferrin	Bos taurus	13-24
17095152-11	2007	Based on these results, we conclude that HO-1 plays a major role in mediating cytoprotection and iron homeostasis against NO toxicity in immortalized and malignant oral keratinocytes.	Iron	97-101	heme oxygenase 1	Homo sapiens	41-45
1953752-5	1991	Since transplasma membrane electron transport increases cell growth and thymidine incorporation, ceruloplasmin may act as a terminal oxidase for ferrous iron or ascorbate to stimulate transplasma membrane electron transport.	Iron	145-157	ceruloplasmin	Cricetulus griseus	97-110
1660847-5	1991	The activity of myeloperoxidase in the iron-deficient neutrophils was also significantly lower than that in the control cells.	Iron	39-43	myeloperoxidase	Rattus norvegicus	16-31
17383861-5	2007	Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart.	Iron	36-40	hephaestin	Rattus norvegicus	106-116
1660847-7	1991	One week after iron administration, the low values of the peak CL, the five minutes integrated CL and the activity of myeloperoxidase all went up apparently, but not reached the normal levels yet.	Iron	15-19	myeloperoxidase	Rattus norvegicus	118-133
17383861-5	2007	Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart.	Iron	36-40	hephaestin	Rattus norvegicus	118-122
16927405-5	2007	We found that iron uptake in this cell type is mediated by divalent-metal transporter 1 (DMT1) and transferrin receptor-1 (TfR) whereas Ferroportin-1 is very weakly expressed.	Iron	14-18	solute carrier family 11 member 2	Homo sapiens	59-87
1910315-1	1991	Co2+ inhibited nonenzymatic iron chelate-dependent lipid peroxidation in dispersed lipids, such as ascorbate-supported lipid peroxidation, but not iron-independent lipid peroxidation.	Iron	28-32	complement C2	Homo sapiens	0-3
1910315-2	1991	Histidine partially abolished the Co2+ inhibition of the iron-dependent lipid peroxidation.	Iron	57-61	complement C2	Homo sapiens	34-37
2021648-2	1991	The initial reduction event followed second-order kinetics (k = 1.0 x 10(8) M-1 s-1 at pH 7.0 and 6.4 x 10(7) M-1 s-1 at pH 8.5) and resulted in the formation of the neutral FMN semiquinone and the reduced iron-sulfur cluster (in a ratio of approximately 1:3).	Iron	206-210	formin 1	Homo sapiens	174-177
2021648-5	1991	Treatment of the enzyme with phenylhydrazine, which introduces a phenyl group at the 4a-position of the FMN cofactor, decreased both the rate constant for reduction of the protein and the extent of FMN semiquinone production, while increasing the amount of iron-sulfur center reduction, consistent with the results obtained with the native enzyme.	Iron	257-261	formin 1	Homo sapiens	104-107
16927405-5	2007	We found that iron uptake in this cell type is mediated by divalent-metal transporter 1 (DMT1) and transferrin receptor-1 (TfR) whereas Ferroportin-1 is very weakly expressed.	Iron	14-18	solute carrier family 11 member 2	Homo sapiens	89-93
16927405-7	2007	The expression of DMT1 and HFE barely varies upon endotoxin-induced maturation but TfR is up-regulated and the iron export molecule Ferroportin-1 is down-regulated.	Iron	111-115	solute carrier family 11 member 2	Homo sapiens	18-22
16927405-7	2007	The expression of DMT1 and HFE barely varies upon endotoxin-induced maturation but TfR is up-regulated and the iron export molecule Ferroportin-1 is down-regulated.	Iron	111-115	solute carrier family 40 member 1	Homo sapiens	132-145
1715897-8	1991	PLC/PRF/5 cells were not inhibited by maintenance in up to 60 microM of another chelating agent that has a similar affinity for iron, calcium disodium versenate (EDTA).	Iron	128-132	heparan sulfate proteoglycan 2	Homo sapiens	0-3
16927405-9	2007	Our results indicate that the uptake of iron during DCs development and maturation is mediated by a strong expression of iron-uptake molecules such as DMT1 and TfR as well as a down-regulation of iron export molecules such as Ferroportin-1.	Iron	40-44	solute carrier family 11 member 2	Homo sapiens	151-155
2016326-9	1991	This study demonstrates that the complex role of TNF and IL-1 in iron homeostasis includes modulation of the transferrin receptor.	Iron	65-69	interleukin 1 alpha	Homo sapiens	57-61
16927405-9	2007	Our results indicate that the uptake of iron during DCs development and maturation is mediated by a strong expression of iron-uptake molecules such as DMT1 and TfR as well as a down-regulation of iron export molecules such as Ferroportin-1.	Iron	40-44	solute carrier family 40 member 1	Homo sapiens	226-239
17488680-9	2007	In contrast, hepcidin levels were elevated in thalassemia major, presumably due to transfusions that reduce erythropoietic drive and deliver a large iron load.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	13-21
1646376-1	1991	The initial step in the uptake of iron via ferric pseudobactin by the plant-growth-promoting Pseudomonas putida strain WCS358 is binding to a specific outer-membrane protein.	Iron	34-38	outer membrane protein	Pseudomonas putida	151-173
17488680-12	2007	The lack of hepcidin results in hyperabsorption of dietary iron, but also in iron depletion of macrophages, lowering their secretion of ferritin and, consequently, serum ferritin levels.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	12-20
17488680-12	2007	The lack of hepcidin results in hyperabsorption of dietary iron, but also in iron depletion of macrophages, lowering their secretion of ferritin and, consequently, serum ferritin levels.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	12-20
1649082-0	1991	Effects of ceruloplasmin on superoxide-dependent iron release from ferritin and lipid peroxidation.	Iron	49-53	ceruloplasmin	Homo sapiens	11-24
1649082-2	1991	In addition, CP inhibited superoxide-dependent mobilization of iron from ferritin, suggesting that CP inhibited lipid peroxidation by decreasing the availability of iron from ferritin.	Iron	63-67	ceruloplasmin	Homo sapiens	13-15
17488680-14	2007	In the presence of higher hepcidin levels, dietary iron absorption is moderated and macrophages retain iron, contributing to higher serum ferritin.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	26-34
1649082-2	1991	In addition, CP inhibited superoxide-dependent mobilization of iron from ferritin, suggesting that CP inhibited lipid peroxidation by decreasing the availability of iron from ferritin.	Iron	63-67	ceruloplasmin	Homo sapiens	99-101
1649082-2	1991	In addition, CP inhibited superoxide-dependent mobilization of iron from ferritin, suggesting that CP inhibited lipid peroxidation by decreasing the availability of iron from ferritin.	Iron	165-169	ceruloplasmin	Homo sapiens	13-15
1649082-2	1991	In addition, CP inhibited superoxide-dependent mobilization of iron from ferritin, suggesting that CP inhibited lipid peroxidation by decreasing the availability of iron from ferritin.	Iron	165-169	ceruloplasmin	Homo sapiens	99-101
17488680-14	2007	In the presence of higher hepcidin levels, dietary iron absorption is moderated and macrophages retain iron, contributing to higher serum ferritin.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	26-34
17488680-15	2007	In the future, hepcidin measurements may allow a more accurate assessment of the degree of iron overload and the maldistribution of iron in thalassemia.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	15-23
17488680-15	2007	In the future, hepcidin measurements may allow a more accurate assessment of the degree of iron overload and the maldistribution of iron in thalassemia.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	15-23
2010659-3	1991	All 6 GM-CSF-expressing leukemia samples simultaneously displayed high levels of transcripts for the c-fes proto-oncogene previously shown to be expressed in GM-CSF sensitive myeloid cells, whereas only 2 of the 48 AML samples not expressing GM-CSF accumulated c-fes mRNA.	Iron	103-106	colony stimulating factor 2	Homo sapiens	6-12
2010659-3	1991	All 6 GM-CSF-expressing leukemia samples simultaneously displayed high levels of transcripts for the c-fes proto-oncogene previously shown to be expressed in GM-CSF sensitive myeloid cells, whereas only 2 of the 48 AML samples not expressing GM-CSF accumulated c-fes mRNA.	Iron	103-106	colony stimulating factor 2	Homo sapiens	158-164
2010659-3	1991	All 6 GM-CSF-expressing leukemia samples simultaneously displayed high levels of transcripts for the c-fes proto-oncogene previously shown to be expressed in GM-CSF sensitive myeloid cells, whereas only 2 of the 48 AML samples not expressing GM-CSF accumulated c-fes mRNA.	Iron	103-106	colony stimulating factor 2	Homo sapiens	158-164
18214015-2	2007	Since each ferritin molecule can bind thousands of iron atoms, this may be a sustainable means to increase the iron content of plants.	Iron	51-55	ferritin-1, chloroplastic	Glycine max	11-19
1925068-6	1991	LPS and iron particles, however, were more efficient in stimulating IL-1 production.	Iron	8-12	interleukin 1 alpha	Homo sapiens	68-72
2125819-3	1990	A ferroxidase, ceruloplasmin, significantly inhibited the lipid peroxidation induced by the dopa-Fe3+ complex, indicating the importance of the reduction of the iron moiety in the complex for the lipid peroxidation.	Iron	161-165	ceruloplasmin	Homo sapiens	15-28
2264818-0	1990	Purification and characterization of an iron-induced ferritin from soybean (Glycine max) cell suspensions.	Iron	40-44	ferritin-1, chloroplastic	Glycine max	53-61
2264818-3	1990	This iron-induced ferritin has been purified from cells grown for 72 h in the presence of either 100 microM- or 500 microM-ferric citrate.	Iron	5-9	ferritin-1, chloroplastic	Glycine max	18-26
2264818-7	1990	However, the percentage of iron stored in the mineral core of ferritin remains constant whatever the ferric citrate concentration used and represents only 5-6% of cellular iron.	Iron	27-31	ferritin-1, chloroplastic	Glycine max	62-70
2264818-7	1990	However, the percentage of iron stored in the mineral core of ferritin remains constant whatever the ferric citrate concentration used and represents only 5-6% of cellular iron.	Iron	172-176	ferritin-1, chloroplastic	Glycine max	62-70
2229357-1	1990	Bovine lactoferrin (BLf), an acute-phase iron-binding secretory protein present in secretions of the bovine udder, was demonstrated to bind to the following staphylococcal species associated with bovine intramammary infections: S. epidermidis, S. warneri, S. hominis, S. xylosus, S. hyicus, and S. chromogenes.	Iron	41-45	lactotransferrin	Bos taurus	7-18
2386798-6	1990	In the presence of iron and ascorbate, photoperoxidized liposomes underwent a burst of thiobarbituric acid-detectable lipid peroxidation which could be inhibited by prior GSH/PHGPX treatment, but not by GSH/GPX treatment.	Iron	19-23	glutathione peroxidase 4	Homo sapiens	175-180
2333967-0	1990	Iron uptake from transferrin and lactoferrin by rat intestinal brush-border membrane vesicles.	Iron	0-4	lactotransferrin	Rattus norvegicus	33-44
2262014-0	1990	Combined effect of a PUFA deficient diet and iron levels on lipid peroxidation induced by CCl4.	Iron	45-49	C-C motif chemokine ligand 4	Homo sapiens	90-94
2296580-2	1990	The spectra of deoxy myoglobin at low pH within 6 ms of the pH drop demonstrate that the iron-histidine bond has been ruptured but that the heme is still five-coordinate.	Iron	89-93	myoglobin	Homo sapiens	21-30
2296580-6	1990	Three different structural changes are detected at low pH: (i) the iron-proximal histidine (F8) bond in ligand-free myoglobin is broken and replaced by a weak-field ligand, (ii) the distal pocket in MbCO is opened, and (iii) protein constraints on the heme group in MbCO are relaxed.	Iron	67-71	myoglobin	Homo sapiens	116-125
33942218-4	2021	Hepcidin is the major regulatory hormone of systemic iron homeostasis and is upregulated during inflammation.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	0-8
33942218-7	2021	Systemic iron homeostasis is controlled by the hepcidin-ferroportin axis at the sites of iron entry into the circulation.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	47-55
33942218-7	2021	Systemic iron homeostasis is controlled by the hepcidin-ferroportin axis at the sites of iron entry into the circulation.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	47-55
33942218-8	2021	Hepcidin binds to ferroportin, induces its internalization and intracellular degradation, and thus inhibits iron absorption from enterocytes, and iron release from macrophages and hepatocytes.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	0-8
33942218-8	2021	Hepcidin binds to ferroportin, induces its internalization and intracellular degradation, and thus inhibits iron absorption from enterocytes, and iron release from macrophages and hepatocytes.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	0-8
33942218-9	2021	Recent data suggest that hepcidin, by slowing or preventing the mobilization of iron from macrophages, may promote atherosclerosis and may be associated with increased cardiovascular disease risk.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	25-33
33945174-1	2021	OBJECTIVE: Cardiovascular iron load is the leading cause of morbidity and mortality in beta-thalassemia major (beta-TM).	Iron	26-30	ATM serine/threonine kinase	Homo sapiens	87-118
33817815-6	2021	The inhibitory activity of Fe-TPS on alpha-glucosidase was lower than that without Fe.	Iron	27-29	sucrase-isomaltase	Homo sapiens	37-54
33799121-4	2021	Assessment of these changes reveal increased expression of proteins critical for iron uptake, namely transferrin receptor 1 and the divalent metal transporter 1 (DMT1), and decreased expression of the iron exporter, ferroportin-1 (FPN1).	Iron	201-205	solute carrier family 40 member 1	Homo sapiens	216-229
33799121-9	2021	Of note, an atypical IRE exists in the alpha-synuclein 5  UTR that may explain its up-regulation by increased iron.	Iron	110-114	synuclein alpha	Homo sapiens	39-54
33770183-4	2021	No longer needed for the role of cellular detoxification, ABCB7 appears to be used to transport glutathione-coordinated iron-sulfur clusters from mitochondria to the cytosol.	Iron	120-124	ATP binding cassette subfamily B member 7	Homo sapiens	58-63
18214015-2	2007	Since each ferritin molecule can bind thousands of iron atoms, this may be a sustainable means to increase the iron content of plants.	Iron	111-115	ferritin-1, chloroplastic	Glycine max	11-19
18214015-3	2007	Before launching such efforts it is important to determine whether ferritin-bound iron is bioavailable.	Iron	82-86	ferritin-1, chloroplastic	Glycine max	67-75
18214015-5	2007	In Caco-2 cells, we found that dietary factors affecting iron absorption, such as ascorbic acid, phytate, and calcium, had very limited effect on iron uptake from intact ferritin, suggesting that ferritin-bound iron is absorbed via a mechanism different from that of non-heme iron.	Iron	57-61	ferritin-1, chloroplastic	Glycine max	196-204
18214015-8	2007	In human subjects, we found that iron absorption from animal ferritin was similar to that from ferrous sulfate, suggesting that iron is well absorbed from ferritin.	Iron	33-37	ferritin-1, chloroplastic	Glycine max	61-69
18214015-8	2007	In human subjects, we found that iron absorption from animal ferritin was similar to that from ferrous sulfate, suggesting that iron is well absorbed from ferritin.	Iron	128-132	ferritin-1, chloroplastic	Glycine max	155-163
18214015-10	2007	In a subsequent human study we also found that iron from purified soybean ferritin given in a meal was as well absorbed as ferrous iron.	Iron	47-51	ferritin-1, chloroplastic	Glycine max	74-82
17285345-5	2007	Moreover, the N-terminus appears to block previously defined iron-binding sites located on the carboxylate-rich surface defined by the helix (alpha1) and the beta-sheet (beta1), most likely through electrostatic contact with the carboxylate-rich surface on the core protein, as well as inhibiting iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU.	Iron	61-65	adrenoceptor alpha 1D	Homo sapiens	142-148
17285345-5	2007	Moreover, the N-terminus appears to block previously defined iron-binding sites located on the carboxylate-rich surface defined by the helix (alpha1) and the beta-sheet (beta1), most likely through electrostatic contact with the carboxylate-rich surface on the core protein, as well as inhibiting iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU.	Iron	297-301	adrenoceptor alpha 1D	Homo sapiens	142-148
17285345-5	2007	Moreover, the N-terminus appears to block previously defined iron-binding sites located on the carboxylate-rich surface defined by the helix (alpha1) and the beta-sheet (beta1), most likely through electrostatic contact with the carboxylate-rich surface on the core protein, as well as inhibiting iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU.	Iron	297-301	adrenoceptor alpha 1D	Homo sapiens	142-148
17393200-14	2007	Regulation of iron metabolism by hepcidin may be an underestimated response in radiotherapy.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	33-41
17192393-0	2007	RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload.	Iron	77-81	ATP binding cassette subfamily B member 7	Homo sapiens	35-40
33819286-3	2021	The HIF prolyl hydroxylase domain (PHD/EGLN) family of proteins are iron-dependent, oxygen-sensing enzymes that regulate the stability of hypoxia inducible factor-1alpha (HIF-1alpha) and also mediate oxidative stress caused by free iron liberated from the lysis of blood.	Iron	68-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-169
33819286-3	2021	The HIF prolyl hydroxylase domain (PHD/EGLN) family of proteins are iron-dependent, oxygen-sensing enzymes that regulate the stability of hypoxia inducible factor-1alpha (HIF-1alpha) and also mediate oxidative stress caused by free iron liberated from the lysis of blood.	Iron	68-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	171-181
33819286-3	2021	The HIF prolyl hydroxylase domain (PHD/EGLN) family of proteins are iron-dependent, oxygen-sensing enzymes that regulate the stability of hypoxia inducible factor-1alpha (HIF-1alpha) and also mediate oxidative stress caused by free iron liberated from the lysis of blood.	Iron	232-236	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-169
33819286-3	2021	The HIF prolyl hydroxylase domain (PHD/EGLN) family of proteins are iron-dependent, oxygen-sensing enzymes that regulate the stability of hypoxia inducible factor-1alpha (HIF-1alpha) and also mediate oxidative stress caused by free iron liberated from the lysis of blood.	Iron	232-236	hypoxia inducible factor 1, alpha subunit	Mus musculus	171-181
33777495-2	2021	Hepcidin is a key regulator of iron availability and leads to iron sequestration during the state of iron repletion.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
33777495-2	2021	Hepcidin is a key regulator of iron availability and leads to iron sequestration during the state of iron repletion.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
33777495-2	2021	Hepcidin is a key regulator of iron availability and leads to iron sequestration during the state of iron repletion.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
33777495-3	2021	Decreases in the level of hepcidin in the presence of hypoxia and/or iron limitation allow for greater iron availability for erythropoiesis.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	26-34
33777495-3	2021	Decreases in the level of hepcidin in the presence of hypoxia and/or iron limitation allow for greater iron availability for erythropoiesis.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	26-34
17192393-1	2007	X-linked sideroblastic anemia with ataxia (XLSA/A) is caused by defects of the transporter ABCB7 and is characterized by mitochondrial iron deposition and excess of protoporphyrin in erythroid cells.	Iron	135-139	ATP binding cassette subfamily B member 7	Homo sapiens	91-96
33777495-8	2021	Moreover, supplemental iron can further increase levels of hepcidin.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	59-67
33777495-9	2021	Several novel therapies, including hypoxia-inducible factor prolyl hydroxylase inhibitors and hepcidin inhibitors/antagonists, have shown promise in attenuating the levels and/or activity of hepcidin in anemia of CKD, thus ensuring the availability of iron for erythropoiesis.	Iron	252-256	hepcidin antimicrobial peptide	Homo sapiens	94-102
33777495-9	2021	Several novel therapies, including hypoxia-inducible factor prolyl hydroxylase inhibitors and hepcidin inhibitors/antagonists, have shown promise in attenuating the levels and/or activity of hepcidin in anemia of CKD, thus ensuring the availability of iron for erythropoiesis.	Iron	252-256	hepcidin antimicrobial peptide	Homo sapiens	191-199
17192393-3	2007	The phenotype of the ABCB7-deficient cells was characterized by a strong reduction in proliferation rate that was not rescued by iron supplementation, by evident signs of iron deficiency, and by a large approximately 6-fold increase of iron accumulation in the mitochondria that was poorly available to mitochondrial ferritin.	Iron	129-133	ATP binding cassette subfamily B member 7	Homo sapiens	21-26
33232715-5	2021	Heme iron is incorporated into cells through HCP1, and non-heme iron is transported by DMT1 in absorptive cells.	Iron	64-68	doublesex and mab-3 related transcription factor 1	Homo sapiens	87-91
17192393-3	2007	The phenotype of the ABCB7-deficient cells was characterized by a strong reduction in proliferation rate that was not rescued by iron supplementation, by evident signs of iron deficiency, and by a large approximately 6-fold increase of iron accumulation in the mitochondria that was poorly available to mitochondrial ferritin.	Iron	171-175	ATP binding cassette subfamily B member 7	Homo sapiens	21-26
33803848-9	2021	Finally, with the use of the FE method, the authors were able to obtain stresses in the adhesive layers of lap joints for loads that destroyed that joints in the experiment, and the FEM-calculated failure stresses for lap joints were compared with the adhesive failure stresses determined experimentally using the butt specimens.	Iron	29-31	LAP	Homo sapiens	107-110
17192393-6	2007	The results support the hypothesis that ABCB7 is involved in the transfer of iron from mitochondria to cytosol, and in the maturation of cytosolic Fe/S enzymes.	Iron	77-81	ATP binding cassette subfamily B member 7	Homo sapiens	40-45
17403009-14	2007	Our inference is that the ABCG2 gene may play a minor role in FE sensitivity in sheep, at least within these selection lines.	Iron	62-64	broad substrate specificity ATP-binding cassette transporter ABCG2	Ovis aries	26-31
33804198-1	2021	Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	34-42
33804198-1	2021	Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	34-42
33804198-2	2021	Hepcidin binding leads to FPN internalization and degradation, thereby inhibiting iron release, in particular from iron-absorbing duodenal cells and macrophages involved in iron recycling.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
33804198-2	2021	Hepcidin binding leads to FPN internalization and degradation, thereby inhibiting iron release, in particular from iron-absorbing duodenal cells and macrophages involved in iron recycling.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	0-8
33804198-2	2021	Hepcidin binding leads to FPN internalization and degradation, thereby inhibiting iron release, in particular from iron-absorbing duodenal cells and macrophages involved in iron recycling.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	0-8
17305361-5	2007	The contents of iron, magnesium, zinc, and selenium in the tea and its polysaccharide conjugate were measured by inductively coupled plasma-optical emission spectrometry (ICP-OES).	Iron	16-20	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	59-62
33800732-7	2021	Treatment of iron-overloaded mask mice with erythropoietin increased hemoglobin and hematocrit, indicating that the response to erythropoietin is intact in mask mice.	Iron	13-17	erythropoietin	Mus musculus	44-58
33800732-7	2021	Treatment of iron-overloaded mask mice with erythropoietin increased hemoglobin and hematocrit, indicating that the response to erythropoietin is intact in mask mice.	Iron	13-17	erythropoietin	Mus musculus	128-142
33032619-9	2020	Poor consumption of iron rich foods highly clustered at Southern Afar, Southeastern Amhara and Tigray, and the Northern part of Somali Regional States of Ethiopia.	Iron	20-24	aldo-keto reductase family 7 member A2	Homo sapiens	65-69
12215968-0	2002	GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L.	Iron	51-55	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	99-104
12215968-7	2002	Interestingly, the British and Turkish patients had complex III deficiency, whereas in the Finnish patients with GRACILE syndrome complex III activity was within the normal range, implying that BCS1L has another cellular function that is uncharacterized but essential and is putatively involved in iron metabolism.	Iron	298-302	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	194-199
17305361-7	2007	Especially, the content of iron in tea polysaccharide conjugate was increased 5.9 times.	Iron	27-31	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	35-38
17375196-4	2007	Among impaired genes we identified ceruloplasmin (Cp), which plays a key role in iron metabolism and is implicated in a neurodegenative disease.	Iron	81-85	ceruloplasmin	Mus musculus	35-48
34906694-3	2022	In this review, we discuss key biometals such as zinc, copper, and iron that interact with protein species involved in AD, mainly Abeta, tau, and the late-onset AD risk factor Apolipoprotein E (APOE).	Iron	67-71	microtubule associated protein tau	Homo sapiens	137-140
17325711-0	2007	The 5"-untranslated region of Parkinson"s disease alpha-synuclein messengerRNA contains a predicted iron responsive element.	Iron	100-104	synuclein alpha	Homo sapiens	50-65
34329496-4	2022	RESULTS: In general, during anemia recovery lectin and alternative complement pathway activity and lactoferrin decreased, because improves iron homeostasis which is critically important in the immune system functions.	Iron	139-143	lactotransferrin	Rattus norvegicus	99-110
34329496-7	2022	CONCLUSIONS: Fermented goat milk consumption enhances immune function modifying complement pathways activity and decreasing pro-inflammatory cytokines as well as lactoferrin concentration, due to the improvement of iron homeostasis which is critically important in the normal function of the immune system.	Iron	215-219	lactotransferrin	Rattus norvegicus	162-173
34775124-3	2022	Here, we designed a theranostic nanoplatform, named FCS/GCS, by incorporating amphiphilic polymer skeletal (P-SS-D), cinnamaldehyde prodrug (CA-OH) and iron ions (Fe3+)/gadolinium ions (Gd3+) via chelation reactions between Fe3+/Gd3+ and polyphenols.	Iron	152-156	GRDX	Homo sapiens	186-189
34775124-3	2022	Here, we designed a theranostic nanoplatform, named FCS/GCS, by incorporating amphiphilic polymer skeletal (P-SS-D), cinnamaldehyde prodrug (CA-OH) and iron ions (Fe3+)/gadolinium ions (Gd3+) via chelation reactions between Fe3+/Gd3+ and polyphenols.	Iron	152-156	GRDX	Homo sapiens	229-232
17172471-4	2007	IKK activation induced by iron is abrogated by overexpression of a dominant negative mutant (DN) for transforming growth factor beta-activated kinase-1 (TAK1), NF-kappaB-inducing kinase, or phosphatidylinositol 3-kinase (PI3K) and by treatment with the mitogen-activated protein kinase (MAPK) kinase-1 (MEK1) inhibitor.	Iron	26-30	mitogen-activated protein kinase kinase 1	Homo sapiens	303-307
34469757-4	2022	Ferroptosis is a new type of programmed cell death caused by iron-dependent accumulation of lipid peroxides, in which glutathione peroxidase 4 (GPX4) is a key protein affecting ferroptosis.	Iron	61-65	glutathione peroxidase 4	Mus musculus	118-142
17172471-7	2007	Iron-induced TAK1 activity is not affected by the PI3K or MEK1 inhibitor, suggesting TAK1 is upstream of PI3K and MEK1.	Iron	0-4	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	13-17
34843656-1	2022	Chronic kidney disease (CKD) involves disturbances in iron metabolism including anemia caused by insufficient erythropoietin (EPO) production.	Iron	54-58	erythropoietin	Mus musculus	110-124
34843656-1	2022	Chronic kidney disease (CKD) involves disturbances in iron metabolism including anemia caused by insufficient erythropoietin (EPO) production.	Iron	54-58	erythropoietin	Mus musculus	126-129
17172471-7	2007	Iron-induced TAK1 activity is not affected by the PI3K or MEK1 inhibitor, suggesting TAK1 is upstream of PI3K and MEK1.	Iron	0-4	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	85-89
34843656-3	2022	Using the unilateral ureteral obstruction (UUO) model in Irp1+/+ and Irp1-/- mice we asked if iron regulatory proteins (IRP), the central regulators of cellular iron metabolism and also suppressors of EPO production, contribute to the etiology of anemia in kidney failure.	Iron	94-98	erythropoietin	Mus musculus	201-204
17172471-7	2007	Iron-induced TAK1 activity is not affected by the PI3K or MEK1 inhibitor, suggesting TAK1 is upstream of PI3K and MEK1.	Iron	0-4	mitogen-activated protein kinase kinase 1	Homo sapiens	114-118
34562018-1	2022	In patients with beta-thalassaemia intermedia or major, hepcidin induces iron overload by continuously promoting iron absorption.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	56-64
34562018-1	2022	In patients with beta-thalassaemia intermedia or major, hepcidin induces iron overload by continuously promoting iron absorption.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	56-64
17172471-8	2007	Iron increases interactions of TAK1 and PI3K with p21ras as demonstrated by co-immunoprecipitation and co-localization of these proteins with caveolin-1 as shown by immunofluorescent microscopy.	Iron	0-4	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	31-35
34562018-6	2022	After iron supplementation, the routine blood parameters and iron metabolism parameters in the beta + IDA group were improved, and the hepcidin content was significantly increased.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	135-143
34562018-7	2022	These results suggest that in pregnant women with beta-thalassaemia minor, hepcidin functions normally to maintain iron homeostasis, and that iron supplementation is effective and safe.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	75-83
17172471-8	2007	Iron increases interactions of TAK1 and PI3K with p21ras as demonstrated by co-immunoprecipitation and co-localization of these proteins with caveolin-1 as shown by immunofluorescent microscopy.	Iron	0-4	H3 histone pseudogene 16	Homo sapiens	50-53
17172471-9	2007	Finally, filipin III, a caveolae inhibitor, abrogates iron-induced TAK1 and IKK activation.	Iron	54-58	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	67-71
34242660-3	2022	Ferroptosis, a cell death modality triggered by iron-dependent lipid peroxidation, reportedly participates in cancer pathogenesis and can mediate the effect of anti-PD-1 immunotherapy in melanoma.	Iron	48-52	spermatogenesis associated 2	Homo sapiens	165-169
17172471-10	2007	In conclusion, MEK1, TAK1, NF-kappa-inducing kinase, and PI3K are required for iron-induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction.	Iron	79-83	mitogen-activated protein kinase kinase 1	Homo sapiens	15-19
17172471-10	2007	In conclusion, MEK1, TAK1, NF-kappa-inducing kinase, and PI3K are required for iron-induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction.	Iron	79-83	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	21-25
34964947-9	2022	In particular, we found that B. thetaiotaomicron induced the expression of hepcidin, the master regulator of iron metabolism and an antimicrobial peptide, in the liver.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	75-83
34376791-1	2022	OBJECTIVE: To examine erythroferrone (ERFE)-hepcidin iron regulation in premature infants under intensive care at risk of iron metabolic disorders.	Iron	53-57	erythroferrone	Homo sapiens	38-42
34376791-1	2022	OBJECTIVE: To examine erythroferrone (ERFE)-hepcidin iron regulation in premature infants under intensive care at risk of iron metabolic disorders.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	44-52
34376791-1	2022	OBJECTIVE: To examine erythroferrone (ERFE)-hepcidin iron regulation in premature infants under intensive care at risk of iron metabolic disorders.	Iron	122-126	erythroferrone	Homo sapiens	38-42
34376791-1	2022	OBJECTIVE: To examine erythroferrone (ERFE)-hepcidin iron regulation in premature infants under intensive care at risk of iron metabolic disorders.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	44-52
17172471-10	2007	In conclusion, MEK1, TAK1, NF-kappa-inducing kinase, and PI3K are required for iron-induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction.	Iron	79-83	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	134-138
34376791-7	2022	CONCLUSION: The vulnerability of the ERFE-hepcidin pathway within 4 weeks may contribute to iron imbalance in premature infants.	Iron	92-96	erythroferrone	Homo sapiens	37-41
34376791-7	2022	CONCLUSION: The vulnerability of the ERFE-hepcidin pathway within 4 weeks may contribute to iron imbalance in premature infants.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	42-50
17172471-10	2007	In conclusion, MEK1, TAK1, NF-kappa-inducing kinase, and PI3K are required for iron-induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction.	Iron	79-83	HRas proto-oncogene, GTPase	Homo sapiens	150-156
17291111-2	2007	These iron-molybdenum complexes consist of organometallic and inorganic fragments linked each other through a pi-conjugated aryldiazenido bridge coordinated in eta6 and eta1 modes, respectively.	Iron	6-10	secreted phosphoprotein 1	Homo sapiens	169-173
34841438-1	2022	Heme oxygenase-1 (HO-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin.	Iron	91-95	heme oxygenase 1	Homo sapiens	0-16
34841438-1	2022	Heme oxygenase-1 (HO-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin.	Iron	91-95	heme oxygenase 1	Homo sapiens	18-22
34965856-0	2021	FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis.	Iron	107-111	ferritin heavy chain 1	Homo sapiens	0-3
17142287-1	2007	We report on the structure and dynamics of the Fe ligand cluster of reduced horse heart cytochrome c in solution, in a dried polyvinyl alcohol (PVA) film, and in two trehalose matrices characterized by different contents of residual water.	Iron	47-49	cytochrome c, somatic	Equus caballus	88-100
34965856-2	2021	Ferritin heavy chain (FTH) is a major iron storing nanocage to store redox-inactive iron, and harbors ferroxidase activity to prevent the iron-mediated production of ROS.	Iron	38-42	ferritin heavy chain 1	Homo sapiens	0-20
34965856-2	2021	Ferritin heavy chain (FTH) is a major iron storing nanocage to store redox-inactive iron, and harbors ferroxidase activity to prevent the iron-mediated production of ROS.	Iron	38-42	ferritin heavy chain 1	Homo sapiens	22-25
34965856-2	2021	Ferritin heavy chain (FTH) is a major iron storing nanocage to store redox-inactive iron, and harbors ferroxidase activity to prevent the iron-mediated production of ROS.	Iron	84-88	ferritin heavy chain 1	Homo sapiens	0-20
34965856-2	2021	Ferritin heavy chain (FTH) is a major iron storing nanocage to store redox-inactive iron, and harbors ferroxidase activity to prevent the iron-mediated production of ROS.	Iron	84-88	ferritin heavy chain 1	Homo sapiens	22-25
34965856-2	2021	Ferritin heavy chain (FTH) is a major iron storing nanocage to store redox-inactive iron, and harbors ferroxidase activity to prevent the iron-mediated production of ROS.	Iron	138-142	ferritin heavy chain 1	Homo sapiens	0-20
34965856-2	2021	Ferritin heavy chain (FTH) is a major iron storing nanocage to store redox-inactive iron, and harbors ferroxidase activity to prevent the iron-mediated production of ROS.	Iron	138-142	ferritin heavy chain 1	Homo sapiens	22-25
34965856-12	2021	Importantly, the proteins interaction network elucidated that FTH is involved in iron homeostasis maintenance and lysosomal-dependent degradation.	Iron	81-85	ferritin heavy chain 1	Homo sapiens	62-65
17255318-2	2007	Hepcidin, a negative regulator of intestinal iron absorption, is found to be inappropriately low in both patients and in animal models, indicating that proper control of basal hepcidin levels requires both hemojuvelin and HFE.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
34974896-8	2021	Hepcidin, erythroferrone and erythropoietin are regulatory hormones that are integral to iron homeostasis.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
34974896-8	2021	Hepcidin, erythroferrone and erythropoietin are regulatory hormones that are integral to iron homeostasis.	Iron	89-93	erythroferrone	Homo sapiens	10-24
16946298-2	2007	Inappropriately low hepcidin levels cause iron overload, while increased hepcidin expression plays an important role in the anemia of inflammation (AI) by restricting intestinal iron absorption and macrophage iron release.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	20-28
34954079-7	2022	Additionally, the induction of TET1 expression was found post-iron treatment, highlighting the possibility of an oxidative-stress induction of TET1 and subsequent hypomethylation of NRF2 targets.	Iron	62-66	tet methylcytosine dioxygenase 1	Homo sapiens	31-35
34954079-7	2022	Additionally, the induction of TET1 expression was found post-iron treatment, highlighting the possibility of an oxidative-stress induction of TET1 and subsequent hypomethylation of NRF2 targets.	Iron	62-66	tet methylcytosine dioxygenase 1	Homo sapiens	143-147
34954079-10	2022	Furthermore, significant correlations were found between NQO1 and GPX2 demethylation and human intestinal tissue iron-status, thus suggesting that these iron-mediated epigenetic modifications are likely in iron-replete enterocytes.	Iron	153-157	glutathione peroxidase 2	Homo sapiens	66-70
16946298-2	2007	Inappropriately low hepcidin levels cause iron overload, while increased hepcidin expression plays an important role in the anemia of inflammation (AI) by restricting intestinal iron absorption and macrophage iron release.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	73-81
34791391-1	2021	Fe(II) exported from cells is oxidized to Fe(III), possibly by a multi-copper ferroxidase (MCF) such as ceruloplasmin (CP), to efficiently bind with the plasma iron transport protein transferrin (TF).	Iron	160-164	ceruloplasmin	Homo sapiens	119-121
34791391-5	2021	Using spectrophotometric, isothermal titration calorimetric, and surface plasmon resonance methods, we found that Zn(II)-bound CP bound to iron-free TF (apo-TF) with a Kd of 4.2 muM and a stoichiometry CP:TF of ~2:1.	Iron	139-143	ceruloplasmin	Homo sapiens	127-129
34791391-5	2021	Using spectrophotometric, isothermal titration calorimetric, and surface plasmon resonance methods, we found that Zn(II)-bound CP bound to iron-free TF (apo-TF) with a Kd of 4.2 muM and a stoichiometry CP:TF of ~2:1.	Iron	139-143	aminopeptidase O (putative)	Homo sapiens	153-156
34791391-10	2021	Our findings suggest that zinc may be involved in the transfer of iron between CP and TF.	Iron	66-70	ceruloplasmin	Homo sapiens	79-81
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	105-109	LIF receptor alpha	Mus musculus	25-29
34921145-5	2021	Mechanistically, loss of LIFR activates NF-kappaB signaling through SHP1, leading to upregulation of the iron-sequestering cytokine LCN2, which depletes iron and renders insensitivity to ferroptosis inducers.	Iron	153-157	LIF receptor alpha	Mus musculus	25-29
16946298-2	2007	Inappropriately low hepcidin levels cause iron overload, while increased hepcidin expression plays an important role in the anemia of inflammation (AI) by restricting intestinal iron absorption and macrophage iron release.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	73-81
17098454-11	2007	CONCLUSIONS: These findings suggest that patients with HH, in contrast to those with physiological iron overload, have a weakened TfR2 sensing mechanism that leads to the lack of induction of hepcidin and HJV.	Iron	99-103	transferrin receptor 2	Homo sapiens	130-134
17126400-1	2007	Hepcidin, originally identified as a 25 amino acid antimicrobial peptide made in the liver, is a key regulator of iron balance and recycling in humans and mice.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	0-8
17187402-0	2007	The nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	38-46
17187402-2	2007	Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
17187402-4	2007	Transcript levels of genes involved in intestinal iron absorption, including Dcytb, DMT1, and ferroportin, are significantly elevated in the absence of hepcidin.	Iron	50-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	84-88
17187402-6	2007	Moreover, transcriptional activation of hepcidin is abrogated in SMAD4-deficient hepatocytes in response to iron overload, TGF-beta, BMP, or IL-6.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	40-48
18086376-4	2007	We found that macrophages lacking functional Nramp1 exhibited a significantly higher iron uptake via transferrin receptor 1 and, as a consequence of this, an increased iron release which is mediated via the iron export protein ferroportin-1.	Iron	85-89	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	45-51
18086376-4	2007	We found that macrophages lacking functional Nramp1 exhibited a significantly higher iron uptake via transferrin receptor 1 and, as a consequence of this, an increased iron release which is mediated via the iron export protein ferroportin-1.	Iron	168-172	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	45-51
18086376-4	2007	We found that macrophages lacking functional Nramp1 exhibited a significantly higher iron uptake via transferrin receptor 1 and, as a consequence of this, an increased iron release which is mediated via the iron export protein ferroportin-1.	Iron	168-172	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	45-51
18086376-5	2007	RNA-bandshift experiments for determination of iron regulatory protein activity showed that, as a net effect of the altered expression of iron transporters, the overall cellular iron content was lower in macrophages bearing functional Nramp1.	Iron	47-51	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	235-241
18086376-5	2007	RNA-bandshift experiments for determination of iron regulatory protein activity showed that, as a net effect of the altered expression of iron transporters, the overall cellular iron content was lower in macrophages bearing functional Nramp1.	Iron	138-142	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	235-241
18086376-6	2007	Since low intracellular iron availability enhances iNOS transcription, Nramp1 could exert its effect on NO formation and other pro-inflammatory immune pathways via modulation of iron homeostasis.	Iron	178-182	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	71-77
17215586-2	2007	Our understanding of the molecular control of iron metabolism has increased dramatically over the past 5 years due to the discovery of hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	135-143
17215586-6	2007	The aim of this review is to summarize the current knowledge dealing with a possible role of hepcidin in iron metabolism and its regulation, particularly in kidney disease.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	93-101
17353176-11	2007	In comparison with CHr, the value of 30.5 pg for RET-He appeared to be the best cut-off point with a very good sensitivity and specificity to determine patients needing iron supplementation.	Iron	169-173	ret proto-oncogene	Homo sapiens	49-52
17353176-12	2007	Our study showed an excellent diagnostic efficiency of RET-He to evaluate patients needing iron support and demonstrated a strict correspondence between the classic CHr and the new Ret-He.	Iron	91-95	ret proto-oncogene	Homo sapiens	55-58
17018578-1	2007	Heme oxygenase-1 (HO1), which oxidizes heme to biliverdin, CO, and free iron, conveys protection against oxidative stress and is antiapoptotic.	Iron	72-76	heme oxygenase 1	Homo sapiens	0-16
17018578-1	2007	Heme oxygenase-1 (HO1), which oxidizes heme to biliverdin, CO, and free iron, conveys protection against oxidative stress and is antiapoptotic.	Iron	72-76	heme oxygenase 1	Homo sapiens	18-21
17515961-0	2007	Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Patients with chronic hepatitis C frequently have serum and hepatic iron overload, but the mechanism is unknown.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	0-8
16220548-1	2007	BACKGROUND: Hepcidin, a regulator for iron homeostasis, is induced by inflammation and iron burden and suppressed by anemia and hypoxia.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	12-20
34952351-0	2022	Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology.	Iron	44-48	microtubule associated protein tau	Homo sapiens	118-121
16220548-1	2007	BACKGROUND: Hepcidin, a regulator for iron homeostasis, is induced by inflammation and iron burden and suppressed by anemia and hypoxia.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	12-20
17211147-8	2007	Our study indicates that apo-hLf alleviates H2O2-induced oxidative damage in intestinal cells due to the iron-chelating capacity.	Iron	105-109	HLF transcription factor, PAR bZIP family member	Homo sapiens	29-32
34678238-4	2021	Previous studies indicated that HIF-PHIs may decrease hepcidin levels and modulate iron metabolism, thereby increasing total iron-binding capacity and reducing the need for iron supplementation.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	54-62
17168739-5	2006	Concurrently, the hypoxia-inducible factor (HIF) has also been shown in previous studies to regulate intracellular iron by binding to HIF-responsive elements (HREs) that are located within the genes of iron-related proteins such as TfR and heme oxygenase-1 (HO-1).	Iron	115-119	heme oxygenase 1	Homo sapiens	240-256
34857917-7	2021	GPX4 depletion and ferroptosis were linked to impaired NRF2 signalling and dysregulation of glutathione synthesis and iron-binding proteins.	Iron	118-122	glutathione peroxidase 4	Mus musculus	0-4
34857788-5	2021	pH 4 and the presence of aluminum in PLS clearly decreased the separation efficiency of Fe vs. active material metals (Ni, Co, Li).	Iron	88-90	prolyl 4-hydroxylase, transmembrane	Homo sapiens	0-4
34800311-0	2021	Vam6/Vps39/TRAP1-domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans.	Iron	64-68	VPS39 subunit of HOPS complex	Homo sapiens	5-10
34800311-3	2021	In this study, we characterized one such mutant and found that the defective gene encoded a Vam6/Vps39/TRAP1 domain-containing protein required for robust growth on heme, an important iron source in host tissue.	Iron	184-188	VPS39 subunit of HOPS complex	Homo sapiens	92-96
34800311-3	2021	In this study, we characterized one such mutant and found that the defective gene encoded a Vam6/Vps39/TRAP1 domain-containing protein required for robust growth on heme, an important iron source in host tissue.	Iron	184-188	VPS39 subunit of HOPS complex	Homo sapiens	97-102
34800311-5	2021	C. neoformans encodes a second Vam6/Vps39/TRAP1 domain-containing protein designated Vam6/Vlp1, and we found that this protein is also required for robust growth on heme as well as on inorganic iron sources.	Iron	194-198	VPS39 subunit of HOPS complex	Homo sapiens	36-41
17168739-5	2006	Concurrently, the hypoxia-inducible factor (HIF) has also been shown in previous studies to regulate intracellular iron by binding to HIF-responsive elements (HREs) that are located within the genes of iron-related proteins such as TfR and heme oxygenase-1 (HO-1).	Iron	115-119	heme oxygenase 1	Homo sapiens	258-262
17168739-5	2006	Concurrently, the hypoxia-inducible factor (HIF) has also been shown in previous studies to regulate intracellular iron by binding to HIF-responsive elements (HREs) that are located within the genes of iron-related proteins such as TfR and heme oxygenase-1 (HO-1).	Iron	202-206	heme oxygenase 1	Homo sapiens	240-256
17168739-5	2006	Concurrently, the hypoxia-inducible factor (HIF) has also been shown in previous studies to regulate intracellular iron by binding to HIF-responsive elements (HREs) that are located within the genes of iron-related proteins such as TfR and heme oxygenase-1 (HO-1).	Iron	202-206	heme oxygenase 1	Homo sapiens	258-262
34288431-6	2021	This preliminary study investigated whether hepcidin, the master regulator of iron homeostasis, in conjunction with reticulocyte haemoglobin equivalent (RetHe) has the potential to differentiate IDA from ACD, and to exclude IDA in patients with mixed aetiology.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	44-52
17105307-2	2006	Coordination of 1 to group 8 transition metal centers furnishes the eta1-complexes [MH(dppe)2(Ph3CC[triple bond]P)]OTf, where M = Fe (3) or Ru (4) (dppe = bis-1,2-diphenylphosphinoethane).	Iron	130-132	secreted phosphoprotein 1	Homo sapiens	68-72
34740612-1	2021	Liver sinusoidal endothelial cells (LSECs) derived bone morphogenetic protein 6 (BMP6) and the BMP6/SMAD signaling pathway are essential for expression of hepcidin, the secretion of which is considered the systemic master switch of iron homeostasis.	Iron	232-236	hepcidin antimicrobial peptide	Homo sapiens	155-163
34740612-2	2021	However, there are continued controversies related to the strong and direct suppressive effect of iron on hepatocellular hepcidin in vitro in contrast to in vivo conditions.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	121-129
34740612-8	2021	Efficient blockage of this EC-mediated hepcidin upregulation by an inhibitor of BMP6 receptor ALK2/3 or BMP6 siRNA identified BMP6 as a major hepcidin regulator in this co-culture system, which highly fits the model of hepcidin regulation by iron in vivo.	Iron	242-246	hepcidin antimicrobial peptide	Homo sapiens	219-227
34740612-10	2021	We here establish a hepatocyte-endothelial co-culture system to fully recapitulate iron regulation by hepcidin using EC-derived BMP6.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	102-110
17064691-5	2006	The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.	Iron	40-44	gastrin	Homo sapiens	68-75
34882347-3	2021	One of the possible markers of the severe course of COVID-19 is hepcidin, a peptide hormone that negatively regulates iron metabolism.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	64-72
34811513-0	2021	Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.	Iron	17-21	CDC-like kinase 1	Mus musculus	74-78
34811513-6	2021	Notably, significantly decreased iron content in striatum and hippocampus was evident in both Clk1+/- mutant mice and PC12 cells with Clk1 knockdown.	Iron	33-37	CDC-like kinase 1	Mus musculus	94-98
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	14-18	hypoxia inducible factor 1, alpha subunit	Mus musculus	152-183
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	14-18	hypoxia inducible factor 1, alpha subunit	Mus musculus	185-195
17064691-5	2006	The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.	Iron	136-140	gastrin	Homo sapiens	68-75
16950787-7	2006	Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and deferoxamine (an iron chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation was further investigated.	Iron	219-223	heme oxygenase 1	Homo sapiens	232-236
34739212-0	2021	Bacterial Responses to Iron Withholding by Calprotectin.	Iron	23-27	ceruloplasmin	Homo sapiens	43-55
34739212-3	2021	In this Perspective, we review recent studies that have established a foundation for our understanding of the impact of the metal-sequestering host defense protein calprotectin (CP) on bacterial Fe homeostasis.	Iron	195-197	ceruloplasmin	Homo sapiens	164-176
34739212-3	2021	In this Perspective, we review recent studies that have established a foundation for our understanding of the impact of the metal-sequestering host defense protein calprotectin (CP) on bacterial Fe homeostasis.	Iron	195-197	ceruloplasmin	Homo sapiens	178-180
34739212-4	2021	We also discuss two recently uncovered strategies for bacterial adaptation to Fe withholding by CP.	Iron	78-80	ceruloplasmin	Homo sapiens	96-98
16929540-3	2006	Cross-sectional study was performed to assess hepcidin correlations with renal function, iron status, and hsCRP in patients with chronic renal failure on conservative treatment, on hemodialyses, and in kidney transplant recipients.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	46-54
34782602-0	2021	Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1.	Iron	0-4	heme oxygenase 1	Homo sapiens	93-98
34782602-5	2021	Iron overload in endometriosis PF disrupted blastocyst formation, decreased GPX4 expression and induced lipid peroxidation, suggesting that iron overload causes embryotoxicity and induces ferroptosis.	Iron	0-4	glutathione peroxidase 4	Homo sapiens	76-80
34782602-5	2021	Iron overload in endometriosis PF disrupted blastocyst formation, decreased GPX4 expression and induced lipid peroxidation, suggesting that iron overload causes embryotoxicity and induces ferroptosis.	Iron	140-144	glutathione peroxidase 4	Homo sapiens	76-80
34743269-5	2022	Then, we inhibited autophagy by ATG5 gene knockout, showing that autophagy inhibition can reduce the intracellular iron level and LPO, improve the expression of ferroptosis-protective proteins, and subsequently alleviate SAH-induced cell death.	Iron	115-119	autophagy related 5	Rattus norvegicus	32-36
34618058-4	2021	By contrast, transcription of the cytochrome P450 family protein CYP82C4, catalyzing the subsequent hydroxylation of fraxetin to sideretin, which forms less stable complexes with iron, was strongly repressed under such conditions.	Iron	179-183	cytochrome P450, family 82, subfamily C, polypeptide 4	Arabidopsis thaliana	65-72
17052927-5	2006	In vitro the binding of AHSP to ferrous alpha-Hb accelerates oxidation of the heme iron in alpha-Hb, but the complex is more resistant to protein unfolding.	Iron	83-87	alpha hemoglobin stabilizing protein	Homo sapiens	24-28
34731167-10	2021	The apoferritin hydrogel also adsorbed Co2+ and Cu2+ ions and released them in the presence of EDTA, while it adsorbed less Ni2+ ions; more Fe3+ ions adsorbed to the apoferritin hydrogel than other metal ions, indicating that the hydrogel keeps the iron storage characteristic of ferritin.	Iron	249-253	ferritin heavy chain 1	Homo sapiens	4-15
34728736-8	2021	Free iron and biliverdin, which are metabolic byproducts of heme catalysis by HO-1, also suppressed the viral infection.	Iron	5-9	heme oxygenase 1	Homo sapiens	78-82
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	60-64	growth factor receptor bound protein 2-associated protein 2	Mus musculus	50-53
34497146-4	2021	Because blood is iron-rich it can result from chronic blood loss, and this is a common mechanism underlying the development of IDA-for example, as a consequence of menstrual or GI blood loss.Approximately a third of men and postmenopausal women presenting with IDA have an underlying pathological abnormality, most commonly in the GI tract.	Iron	17-21	G protein subunit alpha i1	Homo sapiens	331-333
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	66-68	growth factor receptor bound protein 2-associated protein 2	Mus musculus	50-53
34672568-6	2021	The current study provides insight into how mitoNEET releases its (2Fe-2S) in response to highly tuned acidic conditions, the chemistry of which may have further implications in Fe-S biogenesis.	Iron	178-182	CDGSH iron sulfur domain 1	Homo sapiens	44-52
17373273-3	2006	These two phenomenons are modulated in a coordonated fashion by the plasmatic level of hepcidin, a peptide mainly synthetized by the liver, secreted in plasma and modulating the expression of ferroportin, the cellular exporter of iron, and thus the iron egress.	Iron	230-234	hepcidin antimicrobial peptide	Homo sapiens	87-95
17373273-3	2006	These two phenomenons are modulated in a coordonated fashion by the plasmatic level of hepcidin, a peptide mainly synthetized by the liver, secreted in plasma and modulating the expression of ferroportin, the cellular exporter of iron, and thus the iron egress.	Iron	249-253	hepcidin antimicrobial peptide	Homo sapiens	87-95
17373273-4	2006	Numerous factors are able to modulate the hepcidin expression, including iron status, erythropoietic activity, inflammation and hepatic status which are already identified.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	42-50
17373273-5	2006	Abnormalities occurring in the regulation of hepcidin expression may favour the development of iron metabolism disturbance, including systemic iron overload or relative iron deficiency.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	45-53
17373276-2	2006	The central role of hepcidin in the regulation of oral iron absorption d its effects in uraemia have been recently evidenced.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	20-28
17334044-3	2006	Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism.	Iron	164-168	ceruloplasmin	Homo sapiens	0-13
17334044-3	2006	Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism.	Iron	164-168	ceruloplasmin	Homo sapiens	15-17
17334044-3	2006	Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism.	Iron	170-172	ceruloplasmin	Homo sapiens	0-13
17334044-3	2006	Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism.	Iron	170-172	ceruloplasmin	Homo sapiens	15-17
16937259-1	2006	Hepcidin was originally identified as a liver-expressed antimicrobial peptide but further studies have shown that it also has a key role in iron homeostasis.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	0-8
16937259-5	2006	Several alignments were obtained and the best scores were used to build a 3D model of hepcidin containing one atom of iron.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	86-94
16937259-8	2006	The co-purification of iron with both peptides, together with our 3D model, suggest a conformational polymorphism for hepcidin, reminiscent of the iron regulatory proteins IRPs.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	118-126
16937259-8	2006	The co-purification of iron with both peptides, together with our 3D model, suggest a conformational polymorphism for hepcidin, reminiscent of the iron regulatory proteins IRPs.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	118-126
16939499-9	2006	Our results suggest that, in beta-thalassaemia, serum factors might override the potential effect of iron overload on HAMP expression, thereby providing an explanation for the failure to arrest excessive intestinal iron absorption in these patients.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	118-122
16969457-1	2006	The cationic terminal borylene complex [(eta5-C5H5)(CO)2FeB(eta5-C5Me5)][AlCl4] has been isolated from the reaction of [(eta5-C5H5)(CO)2FeB(Cl)(eta1-C5Me5)] with AlCl3 and on the basis of X-ray crystallographic data, spectroscopic data and a DFT calculation it is concluded that the B--&gt;Fe bond order is one.	Iron	56-58	secreted phosphoprotein 1	Homo sapiens	144-148
16759669-4	2006	In this study, we examined the relationship between the iron regulatory hormone hepcidin and RLS.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	80-88
16759669-5	2006	Hepcidin serves as a hormone that signals iron release from cells by interacting with ferroportin.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
16759669-9	2006	Functionally, hepcidin binds to ferroportin to limit iron movement from cells.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	14-22
16988052-3	2006	The multi-copper ferroxidase ceruloplasmin (Cp) converts toxic ferrous iron to its nontoxic ferric form and is required for iron efflux from cells.	Iron	71-75	ceruloplasmin	Mus musculus	29-42
16988052-3	2006	The multi-copper ferroxidase ceruloplasmin (Cp) converts toxic ferrous iron to its nontoxic ferric form and is required for iron efflux from cells.	Iron	124-128	ceruloplasmin	Mus musculus	29-42
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	100-104	solute carrier family 11 member 2	Homo sapiens	0-4
34176164-0	2021	Brain iron enrichment attenuates alpha-synuclein spreading after injection of preformed fibrils.	Iron	6-10	synuclein, alpha	Mus musculus	33-48
34176164-2	2021	Whereas iron is known to bind to alpha-syn, facilitating its aggregation and regulating alpha-syn expression, it is unclear if and how iron also modulates alpha-syn spreading.	Iron	8-12	synuclein, alpha	Mus musculus	33-42
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	100-104	solute carrier family 11 member 2	Homo sapiens	48-55
34176164-2	2021	Whereas iron is known to bind to alpha-syn, facilitating its aggregation and regulating alpha-syn expression, it is unclear if and how iron also modulates alpha-syn spreading.	Iron	8-12	synuclein, alpha	Mus musculus	88-97
34176164-2	2021	Whereas iron is known to bind to alpha-syn, facilitating its aggregation and regulating alpha-syn expression, it is unclear if and how iron also modulates alpha-syn spreading.	Iron	135-139	synuclein, alpha	Mus musculus	155-164
34176164-3	2021	To elucidate the influence of iron on the propagation of alpha-syn pathology, we investigated alpha-syn spreading after stereotactic injection of alpha-syn preformed fibrils (PFFs) into the striatum of mouse brains after neonatal brain iron enrichment.	Iron	30-34	synuclein, alpha	Mus musculus	57-66
34176164-7	2021	Interestingly, quantification of alpha-syn phosphorylated at S129 showed reduced alpha-syn pathology and attenuated spreading to connectome-specific brain regions after brain iron enrichment.	Iron	175-179	synuclein, alpha	Mus musculus	33-42
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	100-104	solute carrier family 11 member 2	Homo sapiens	57-61
34176164-11	2021	However, a redistribution of alpha-syn aggregate pathology and reduction of striatal microglia accumulation in the mouse brain may be mediated via iron-induced alterations of the brain connectome.	Iron	147-151	synuclein, alpha	Mus musculus	29-38
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	100-104	solute carrier family 11 member 2	Homo sapiens	65-71
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	0-4
34296424-0	2021	Iron reduces the propagation of pathological alpha-synuclein: An Editorial Highlight for "Brain iron enrichment attenuates alpha-synuclein spreading after injection of preformed fibrils".	Iron	0-4	synuclein, alpha	Mus musculus	45-60
34296424-0	2021	Iron reduces the propagation of pathological alpha-synuclein: An Editorial Highlight for "Brain iron enrichment attenuates alpha-synuclein spreading after injection of preformed fibrils".	Iron	0-4	synuclein, alpha	Mus musculus	123-138
34296424-0	2021	Iron reduces the propagation of pathological alpha-synuclein: An Editorial Highlight for "Brain iron enrichment attenuates alpha-synuclein spreading after injection of preformed fibrils".	Iron	96-100	synuclein, alpha	Mus musculus	123-138
34296424-2	2021	Previous studies have indicated that iron binds to alpha-synuclein and triggers its aggregation in vitro, and iron is found enriched in Lewy bodies.	Iron	37-41	synuclein, alpha	Mus musculus	51-66
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	48-55
34296424-2	2021	Previous studies have indicated that iron binds to alpha-synuclein and triggers its aggregation in vitro, and iron is found enriched in Lewy bodies.	Iron	110-114	synuclein, alpha	Mus musculus	51-66
34296424-4	2021	have found that the propagation of pathological alpha-synuclein caused by intrastriatal alpha-synuclein preformed fibrils (PFFs) injection was unexpectedly attenuated in rodent brains in a model of brain iron elevation (neonatal iron feeding).	Iron	204-208	synuclein, alpha	Mus musculus	48-63
34296424-4	2021	have found that the propagation of pathological alpha-synuclein caused by intrastriatal alpha-synuclein preformed fibrils (PFFs) injection was unexpectedly attenuated in rodent brains in a model of brain iron elevation (neonatal iron feeding).	Iron	204-208	synuclein, alpha	Mus musculus	88-103
34296424-4	2021	have found that the propagation of pathological alpha-synuclein caused by intrastriatal alpha-synuclein preformed fibrils (PFFs) injection was unexpectedly attenuated in rodent brains in a model of brain iron elevation (neonatal iron feeding).	Iron	229-233	synuclein, alpha	Mus musculus	48-63
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	57-61
34296424-4	2021	have found that the propagation of pathological alpha-synuclein caused by intrastriatal alpha-synuclein preformed fibrils (PFFs) injection was unexpectedly attenuated in rodent brains in a model of brain iron elevation (neonatal iron feeding).	Iron	229-233	synuclein, alpha	Mus musculus	88-103
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	65-71
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	0-4
34508760-9	2021	More importantly, HMOX1 knockdown attenuated Fe2+ overload, reduced iron content and ROS, and alleviated lipid peroxidation, which led to a reduction in ferroptosis in diabetic human endothelial cells.	Iron	68-72	heme oxygenase 1	Homo sapiens	18-23
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	48-55
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	57-61
34464821-0	2021	Assessing the impacts of differential depositional settings and/or anthropogenic perturbations on sulfur and iron diagenesis in sediments of the Bohai Sea and North Yellow Sea.	Iron	109-113	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	151-154
34537326-12	2021	Our results indicate that elevated iron in MSA mice may result from ceruloplasmin dysfunction and provide evidence that targeting iron in MSA could be a viable therapeutic option.	Iron	35-39	ceruloplasmin	Mus musculus	68-81
34536548-4	2021	The classical iron-binding ligand, desferrioxamine (DFO), has demonstrated effective anti-proliferative activity against many cancer-types, particularly neuroblastoma tumors, and has the surprising activity of down-regulating the potent oncogene, N-myc, which is a major oncogenic driver in neuroblastoma.	Iron	14-18	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	247-252
16737442-1	2006	DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes during the transferrin cycle and some transferrin-independent iron uptake in many cells.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	65-71
34836132-5	2021	Lactoferrin (Lf) is an iron-binding protein present in saliva, tears, and breast milk, which has been shown to have antioxidant, anti-inflammatory and anti-apoptotic properties when administered to mothers as a dietary supplement during pregnancy and/or lactation in preclinical studies of developmental brain injuries.	Iron	23-27	lactotransferrin	Rattus norvegicus	0-11
34836132-5	2021	Lactoferrin (Lf) is an iron-binding protein present in saliva, tears, and breast milk, which has been shown to have antioxidant, anti-inflammatory and anti-apoptotic properties when administered to mothers as a dietary supplement during pregnancy and/or lactation in preclinical studies of developmental brain injuries.	Iron	23-27	lactotransferrin	Rattus norvegicus	13-15
16984886-0	2006	Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake.	Iron	102-106	solute carrier family 11 member 2	Homo sapiens	88-92
34129898-8	2021	It reduced the accumulation of labile iron and alleviated lipid peroxidation by enhancing GPX4 activity.	Iron	38-42	glutathione peroxidase 4	Homo sapiens	90-94
34718778-10	2022	These data indicate that NFU4 and NFU5 have a more specific function than previously thought, most likely providing Fe-S clusters to lipoyl synthase.	Iron	116-118	NFU domain protein 4	Arabidopsis thaliana	25-29
16984886-1	2006	HEK293T cells overexpressing divalent metal transporter-1 (DMT1) were established to screen for small-molecule inhibitors of iron uptake.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	29-57
16984886-1	2006	HEK293T cells overexpressing divalent metal transporter-1 (DMT1) were established to screen for small-molecule inhibitors of iron uptake.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	59-63
34786173-7	2021	RESULTS: All iron III forms including FAC efficiently blocked hepcidin mRNA expression at non-toxic dosages in Huh7 cells or primary hepatocytes in a time and dose-dependent manner (P < 0.001; P < 0.05).	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	62-70
34786173-8	2021	Hepcidin blockage could be efficiently blunted by iron chelators salicylaldehyde isonicotinoyl hydrazone (SIH) and Desferal (P < 0.001).	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
34786173-13	2021	CONCLUSION: Iron directly blocks hepatocellular hepcidin signaling through the BMP/SMAD pathway but independent of STAT3.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	48-56
34786173-14	2021	This mechanism may contribute to continued iron overload in many pathophysiological conditions ultimately causing a vicious cycle of continued hepcidin suppression.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	143-151
17699374-5	2006	Finally, the role of hepcidin, a hepatic polypeptide, in the pathophysiology of iron mobilization is reviewed briefly.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	21-29
34269613-5	2021	Internalization of ferrylHb is accompanied by up-regulation of heme oxygenase-1 and H-ferritin and accumulation of iron within lysosomes as a result of heme/iron uptake.	Iron	157-161	heme oxygenase 1	Homo sapiens	63-79
16952548-12	2006	The observed changes in iron status could be due to the role of hepcidin as a negative regulator of intestinal iron absorption and macrophage iron efflux.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	64-72
34647497-4	2021	The expression of miR-31 was positively associated with the consumption of iron (beta = 16.65) and vitamin C (beta = 0.37), and inversely associated with total sugar (beta = -0.88), cholesterol (beta= -0.23), vitamin B9 (beta= -0.37) and zinc (beta = -5.66) intake.	Iron	75-79	microRNA 31	Homo sapiens	18-24
34569243-6	2021	We utilize quantum mechanics/molecular mechanics simulations to investigate the reactions at the canonical Fe-S cluster, where a radical cleavage of the tyrosine substrate takes place and proceeds through a relay of radical intermediates to form HCN and a COO - radical anion.	Iron	107-111	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	246-249
16952548-12	2006	The observed changes in iron status could be due to the role of hepcidin as a negative regulator of intestinal iron absorption and macrophage iron efflux.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	64-72
16952548-12	2006	The observed changes in iron status could be due to the role of hepcidin as a negative regulator of intestinal iron absorption and macrophage iron efflux.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	64-72
16822677-3	2006	The recombinant Ln1 assembled into 24-mer ferritin shells with low efficiency, however, it was able to form heteropolymers that showed a reduced capacity to incorporate iron in vitro.	Iron	169-173	phytanoyl-CoA 2-hydroxylase	Homo sapiens	16-19
34643575-9	2021	Sixty-three percent of the LVAD (mostly intravenous) and 63% of the HTx patients (mostly oral) received iron administration.	Iron	104-108	Zic family member 3	Homo sapiens	68-71
34679725-9	2021	Taken together, these findings suggest that SMILE is a novel transcriptional repressor of BMP-6-mediated hepcidin gene expression, thus contributing to the control of iron homeostasis.	Iron	167-171	CREB/ATF bZIP transcription factor	Mus musculus	44-49
34679725-9	2021	Taken together, these findings suggest that SMILE is a novel transcriptional repressor of BMP-6-mediated hepcidin gene expression, thus contributing to the control of iron homeostasis.	Iron	167-171	bone morphogenetic protein 6	Mus musculus	90-95
34684558-2	2021	The primary aim was to explore the associations between markers of iron metabolism (hepcidin and ferritin) and markers of energy balance (leptin, ghrelin, and the leptin/ghrelin ratio) in both the fasted and postprandial states.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	84-92
34684558-10	2021	Leptin appears to be a mediator in the link between iron metabolism and new-onset diabetes mellitus.	Iron	52-56	leptin	Homo sapiens	0-6
16822677-4	2006	The Ln1 expressed in HeLa cells formed hybrid ferritins, with the endogenous H and L chains, and caused an iron excess phenotype.	Iron	107-111	phytanoyl-CoA 2-hydroxylase	Homo sapiens	4-7
16822677-5	2006	Ferritin inactivation and faster degradation in Ln1 transfectants concurred in increasing iron availability, which was probably responsible for the higher sensitivity to H(2)O(2) toxicity and higher level of oxidized proteins.	Iron	90-94	phytanoyl-CoA 2-hydroxylase	Homo sapiens	48-51
34626018-3	2021	Different from the previously reported single-atom or dual-atom configurations, a new type of ternary-atom catalyst, which consists of atomically dispersed, nitrogen-coordinated Co-Co dimers, and Fe single sites (i.e., Co2 -N6 and Fe-N4 structures) that are coanchored on highly graphitized carbon supports is developed.	Iron	196-198	complement C2	Homo sapiens	219-222
34626018-5	2021	Density functional theory calculations clearly unravels the synergistic effect of the Co2 -N6 and Fe-N4 sites, which can induce higher filling degree of Fe-d orbitals and favors the binding capability to *OH intermediates (the rate determining step).	Iron	153-155	complement C2	Homo sapiens	86-89
34528032-1	2021	We report a regenerable and redox-inactive ZnOxHy layer that was in situ deposited onto metal oxides MOz (M = Co, Fe, and Ni) in alkaline media containing (Zn(OH)4)2- species during water oxidation.	Iron	114-116	lysine acetyltransferase 6A	Homo sapiens	101-104
16822677-6	2006	The findings suggest that the pathogenic effects of Ln1 expression are more likely due to deregulation of cellular iron homeostasis rather than to protein conformational problems.	Iron	115-119	phytanoyl-CoA 2-hydroxylase	Homo sapiens	52-55
34593646-0	2021	Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-alpha/hepcidin axis.	Iron	27-31	endothelial PAS domain protein 1	Mus musculus	99-109
16737972-3	2006	Hepcidin, a circulatory peptide synthesized in the liver, is a key mediator of iron metabolism.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	0-8
34593646-10	2021	Disruption of systemic iron homeostasis by pharmacological HIF2-alpha inhibitor PT2385 or exogenous administration of hepcidin-25 significantly impaired beige fat development.	Iron	23-27	endothelial PAS domain protein 1	Mus musculus	59-69
34251993-0	2021	SIZ1 regulates phosphate deficiency-induced inhibition of primary root growth of Arabidopsis by modulating Fe accumulation and ROS production in its roots.	Iron	107-109	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	0-4
34251993-6	2021	In siz1, the expression of ALMT1 is enhanced and the removal of Fe from Pi-deficient medium suppressed the siz1 mutant phenotype.	Iron	64-66	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	3-7
34251993-6	2021	In siz1, the expression of ALMT1 is enhanced and the removal of Fe from Pi-deficient medium suppressed the siz1 mutant phenotype.	Iron	64-66	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	107-111
16737972-12	2006	Collectively, these findings indicate that alcohol metabolism-mediated oxidative stress regulates hepcidin transcription via C/EBPalpha, which in turn leads to increased duodenal iron transport.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	98-106
34251993-7	2021	In this report, we show that siz1 overaccumulates Fe in its root apoplasts, and consequently, produces more hydroxyl radicals, which are detrimental to root growth.	Iron	50-52	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	29-33
34251993-9	2021	Based on previously published work and the results of the current study, we propose that SIZ1 regulates Pi deficiency-mediated PR growth through modulating the accumulation of Fe and the production of hydroxyl radicals by controlling ALMT1 expression.	Iron	176-178	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	89-93
16923517-0	2006	Homozygous p.M172K mutation of the TFR2 gene in an Italian family with type 3 hereditary hemochromatosis and early onset iron overload.	Iron	121-125	transferrin receptor 2	Homo sapiens	35-39
34684502-1	2021	Hepcidin is a regulator of iron metabolism.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
34684502-12	2021	Carbohydrates and vegetables may affect the gestational iron status through influencing hepcidin levels.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	88-96
34310730-2	2021	Hepcidin, which regulates iron metabolism, increases in iron overload or inflammation and decreases with iron deficiency or activated erythropoiesis.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	0-8
34310730-2	2021	Hepcidin, which regulates iron metabolism, increases in iron overload or inflammation and decreases with iron deficiency or activated erythropoiesis.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
34310730-12	2021	After transplantation, the major determinants of hepcidin were iron status (ferritin at all time points and Tsat at day 56) and erythropoiesis (sTfR or reticulocytes or ERFE), while the impact of inflammation was less clear and clinical parameters had no detectable influence.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	49-57
16923517-1	2006	The p.M172K TFR2 mutation was identified in two Italian siblings aged 32 and 40 years old with primary iron overload.	Iron	103-107	transferrin receptor 2	Homo sapiens	12-16
34310730-14	2021	After allogeneic HCT with or without EPO therapy, significant alterations of hepcidin occur between pretransplant and day 180, in correlation with iron status and inversely with erythroid ERFE.	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	77-85
34467981-11	2021	On the other hand, VA increased the expression of Ascl2 (P = 0.001) although the interaction of VA and iron (P < 0.05) had an effect on the expression of secreted phosphoprotein 1 (Spp1) and Bmi1.	Iron	103-107	BMI1 proto-oncogene, polycomb ring finger	Sus scrofa	191-195
16890146-3	2006	The uptake and distribution of the lipid-soluble, hexadentate iron chelator desferri-Exochelin 772SM (D-Exo) is studied and its efficacy in removing iron from tissue in rodent models is evaluated.	Iron	62-66	5'-3' exoribonuclease 1	Mus musculus	85-88
34530349-4	2021	In the present study, we found that iron overload promoted ferroptosis in hepatocytes by excessively inducing HO-1 expression, which contributed to the progression of liver injury and fibrosis, accompanied by the upregulation of the FGF21 protein level in vitro and in vivo.	Iron	36-40	heme oxygenase 1	Homo sapiens	110-114
16890146-3	2006	The uptake and distribution of the lipid-soluble, hexadentate iron chelator desferri-Exochelin 772SM (D-Exo) is studied and its efficacy in removing iron from tissue in rodent models is evaluated.	Iron	149-153	5'-3' exoribonuclease 1	Mus musculus	85-88
34515804-3	2021	The study also assessed the relationship between serum IL-22 and pro-inflammatory activation (as evidenced by serum level of IL-6) and serum hepcidin (central regulator of systemic iron homeostasis).	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	141-149
16890146-6	2006	To assess actual decreases in cardiac and hepatic iron in response to D-Exo, mice loaded with 42 mg of iron dextran (2100 mg/kg) were studied.	Iron	50-54	5'-3' exoribonuclease 1	Mus musculus	72-75
16890146-8	2006	In iron-loaded mice treated with 7 mg of D-Exo intraperitoneally (i.p.)	Iron	3-7	5'-3' exoribonuclease 1	Mus musculus	43-46
34347379-3	2021	Herein, a trivalent iron doped covalent triazine-based framework (CTF-1) was elaborately designed in this study to finely tune the band structure and photocatalytic property of CTF-1 for H2 production.	Iron	20-24	cardiotrophin 1	Homo sapiens	66-71
16890146-10	2006	During the first 8 h after a D-Exo dose, iron was excreted in the urine.	Iron	41-45	5'-3' exoribonuclease 1	Mus musculus	31-34
34347379-3	2021	Herein, a trivalent iron doped covalent triazine-based framework (CTF-1) was elaborately designed in this study to finely tune the band structure and photocatalytic property of CTF-1 for H2 production.	Iron	20-24	cardiotrophin 1	Homo sapiens	177-182
34616733-4	2021	These effects were mostly reversed by supplementation with bioavailable hemin b, linking ALR function to mitochondrial iron homeostasis.	Iron	119-123	growth factor, augmenter of liver regeneration	Homo sapiens	89-92
16841977-3	2006	The binding affinity toward the low-coordinate Fe follows the trend HCCPh &gt; EtCCEt &gt; CH2CHPh &gt; EtCHCHEt approximately PPh3 &gt; benzene &gt;&gt; N2.	Iron	47-49	protein phosphatase 4 catalytic subunit	Homo sapiens	127-131
34575794-6	2021	The protein level of Ctr1 was also decreased by nitrogen starvation, and addition of copper to the nitrogen starvation medium partially restored iron uptake activity.	Iron	145-149	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	21-25
34498446-8	2021	Since hepcidin degrades ferroportin on the Salmonella-containing vacuole (SCV), we hypothesize that reduced hepcidin in children with SMA might contribute to NTS growth by modulating iron availability for bacterial growth.	Iron	183-187	hepcidin antimicrobial peptide	Homo sapiens	6-14
34498446-8	2021	Since hepcidin degrades ferroportin on the Salmonella-containing vacuole (SCV), we hypothesize that reduced hepcidin in children with SMA might contribute to NTS growth by modulating iron availability for bacterial growth.	Iron	183-187	hepcidin antimicrobial peptide	Homo sapiens	108-116
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	119-123	lactotransferrin	Mus musculus	172-188
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	151-155	lactotransferrin	Mus musculus	172-188
34236433-9	2021	However, cord hepcidin and the hepcidin:erythropoietin (EPO) ratio captured the most variance in newborn iron and hematologic status (>25% of variance explained).	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	31-39
34236433-10	2021	CONCLUSIONS: Neonates born to teens and women carrying multiples were able to produce ERFE in response to neonatal cord iron status and erythropoietic demand.	Iron	120-124	erythroferrone	Homo sapiens	86-90
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	151-155	lactotransferrin	Mus musculus	172-188
16684588-2	2006	Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin.	Iron	151-155	lactotransferrin	Mus musculus	172-188
16755567-5	2006	The hepatic peptide hepcidin, a key regulator of iron metabolism in mammals, was recently found to be low in the urine of beta-thalassemia patients, compared with healthy controls, despite their iron overload.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	20-28
34473412-7	2022	In addition, the iron-binding protein Transferrin 3 was identified as a putative interactor for Orysata, and treatment of S2 cells with Orysata was shown to reduce the intracellular iron concentration.	Iron	17-21	Transferrin 3	Drosophila melanogaster	38-51
34473412-7	2022	In addition, the iron-binding protein Transferrin 3 was identified as a putative interactor for Orysata, and treatment of S2 cells with Orysata was shown to reduce the intracellular iron concentration.	Iron	182-186	Transferrin 3	Drosophila melanogaster	38-51
34217587-3	2021	It is also not precisely known whether other iron-related parameters, including hepcidin (the central regulator of systemic iron homeostasis), are affected under these circumstances.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	80-88
34217587-13	2021	CONCLUSION: Elevated levels of serum ferritin and hepcidin in newly diagnosed diabetics (but not pre-diabetics) indicate dysregulated iron homeostasis, with the former positively associated with insulin resistance in these patients.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	50-58
34386079-9	2021	Further, erastin and RSL3 promoted the transition of aconitase 1 to IRP1, which regulated downstream iron metabolism proteins, including transferrin receptor (TFRC), ferroportin (FPN) and ferritin heavy chain 1 (FTH1).	Iron	101-105	ferritin heavy chain 1	Homo sapiens	212-216
16755567-5	2006	The hepatic peptide hepcidin, a key regulator of iron metabolism in mammals, was recently found to be low in the urine of beta-thalassemia patients, compared with healthy controls, despite their iron overload.	Iron	195-199	hepcidin antimicrobial peptide	Homo sapiens	20-28
16825689-1	2006	BACKGROUND: Although hepcidin is proposed as a regulator of iron absorption, this has not been assessed in humans.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	21-29
34157442-11	2021	Inhibition of mTORC1 led to the downregulation of GPX4 which promoted Lap induced ferroptosis as evidenced by increase of ROS, MDA, Fe 2+ and decrease of GSH.	Iron	132-134	glutathione peroxidase 4	Mus musculus	50-54
34413268-2	2021	Ceruloplasmin (CP) is a multifunctional molecule involved in iron metabolism, but its expression profile, prognostic potential and relationship with immune cell infiltration in BRCA are unknown.	Iron	61-65	ceruloplasmin	Homo sapiens	0-13
34413268-2	2021	Ceruloplasmin (CP) is a multifunctional molecule involved in iron metabolism, but its expression profile, prognostic potential and relationship with immune cell infiltration in BRCA are unknown.	Iron	61-65	ceruloplasmin	Homo sapiens	15-17
34451746-6	2021	The objective of this research was to investigate the effects of leaf shape (curly leaf: CRL) on cottonseed B, Cu, Fe, Mn, Ni (nickel), and Zn in two near-isogenic cotton lines differing in leaf shape (DP 5690 wild-type with normal leaves and DP 5690 CRL).	Iron	115-117	interleukin 31 receptor A	Homo sapiens	89-92
34451746-10	2021	The results showed that, in 2014, both DP 5690 wild-type and Uzbek CRL had higher seed B, Cu, Fe, and Ni than in DP 5690 CRL.	Iron	94-96	interleukin 31 receptor A	Homo sapiens	67-70
34451746-12	2021	However, in 2015, the concentrations of B, Cu, Fe, and Ni, including Mn and Zn, were higher in both DP 5690 wild-type and Uzbek CRL than in DP 5690 CRL.	Iron	47-49	interleukin 31 receptor A	Homo sapiens	128-131
34388243-6	2022	Consistent with Hmox1 upregulation and iron overload, levels of lipid peroxidation and ferroptotic markers increased in SCD mice, which were corrected by hemopexin administration.	Iron	39-43	hemopexin	Mus musculus	154-163
34310123-1	2021	The human mitochondrial protein, mitoNEET (mNT), belongs to the family of small (2Fe-2S) NEET proteins that bind their iron-sulfur clusters with a novel and characteristic 3Cys:1His coordination motif.	Iron	119-123	CDGSH iron sulfur domain 1	Homo sapiens	33-41
34310123-1	2021	The human mitochondrial protein, mitoNEET (mNT), belongs to the family of small (2Fe-2S) NEET proteins that bind their iron-sulfur clusters with a novel and characteristic 3Cys:1His coordination motif.	Iron	119-123	CDGSH iron sulfur domain 1	Homo sapiens	89-93
34394834-2	2021	As a central regulator of iron homeostasis, whether hepcidin is involved in OSA-induced cognitive impairment has not been clarified.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	52-60
34160288-10	2021	The findings demonstrate that hepcidin and ERFE are more rapid biomarkers of changes in iron demands than routine iron markers.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	30-38
34160288-10	2021	The findings demonstrate that hepcidin and ERFE are more rapid biomarkers of changes in iron demands than routine iron markers.	Iron	88-92	erythroferrone	Homo sapiens	43-47
34280433-0	2021	The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.	Iron	101-105	caseinolytic mitochondrial matrix peptidase chaperone subunit X	Homo sapiens	47-51
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	35-37	caspase recruitment domain family member 16	Homo sapiens	44-47
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	35-37	caspase recruitment domain family member 16	Homo sapiens	83-86
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	35-37	caspase recruitment domain family member 16	Homo sapiens	153-156
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	80-82	caspase recruitment domain family member 16	Homo sapiens	44-47
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	80-82	caspase recruitment domain family member 16	Homo sapiens	83-86
34401687-0	2021	Threshold ferritin and hepcidin concentrations indicating early iron deficiency in young women based on upregulation of iron absorption.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	23-31
34401687-3	2021	We hypothesized this threshold ferritin concentration would correspond to the threshold hepcidin concentration at which iron absorption begins to increase.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	88-96
34401687-7	2021	Iron absorption began to increase below a threshold hepcidin value of 3.09 (95%CI: 2.80, 3.38) nmol/l, above which iron absorption remained stable.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	52-60
34360974-1	2021	Erythropoietin (EPO) downregulates hepcidin expression to increase the availability of iron; the downregulation of hepcidin is mediated by erythroferrone (ERFE) secreted by erythroblasts.	Iron	87-91	erythropoietin	Mus musculus	0-14
34360974-1	2021	Erythropoietin (EPO) downregulates hepcidin expression to increase the availability of iron; the downregulation of hepcidin is mediated by erythroferrone (ERFE) secreted by erythroblasts.	Iron	87-91	erythropoietin	Mus musculus	16-19
34395447-3	2021	In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism.	Iron	117-121	tumor protein p63	Homo sapiens	91-94
34360779-1	2021	Pro-inflammatory cytokines promote cellular iron-import through enhanced divalent metal transporter-1 (DMT1) expression in pancreatic beta-cells, consequently cell death.	Iron	44-48	solute carrier family 11 member 2	Homo sapiens	73-101
34360779-1	2021	Pro-inflammatory cytokines promote cellular iron-import through enhanced divalent metal transporter-1 (DMT1) expression in pancreatic beta-cells, consequently cell death.	Iron	44-48	solute carrier family 11 member 2	Homo sapiens	103-107
16790283-4	2006	Hepcidin acts by binding to and inducing the degradation of the cellular iron exporter, ferroportin, found in sites of major iron flows: duodenal enterocytes involved in iron absorption, macrophages that recycle iron from senescent erythrocytes, and hepatocytes that store iron.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	0-8
34360779-2	2021	Inhibition of beta-cell iron-import by DMT1 silencing protects against apoptosis in animal models of diabetes.	Iron	24-28	solute carrier family 11 member 2	Homo sapiens	39-43
34439408-2	2021	While numerous studies linked beta-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated with hereditary conditions that result in iron overload, e.g., hemochromatosis, Friedreich"s ataxia, and Wolfram syndrome type 2 (WFS-T2; a mutation in CISD2, encoding the (2Fe-2S) protein NAF-1), underscores an additional link between iron metabolism and beta-cell failure.	Iron	184-188	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	331-336
34439408-2	2021	While numerous studies linked beta-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated with hereditary conditions that result in iron overload, e.g., hemochromatosis, Friedreich"s ataxia, and Wolfram syndrome type 2 (WFS-T2; a mutation in CISD2, encoding the (2Fe-2S) protein NAF-1), underscores an additional link between iron metabolism and beta-cell failure.	Iron	378-382	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	331-336
34439408-6	2021	Our findings reveal that suppressed expression of NAF-1 is associated with the development of ferroptosis-like features in pancreatic cells, and that reducing the levels of mitochondrial iron and ROS levels could be used as a therapeutic avenue for WFS-T2 patients.	Iron	187-191	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	50-55
16831606-0	2006	Hepatic iron overload associated with a decreased serum ceruloplasmin level in a novel clinical type of aceruloplasminemia.	Iron	8-12	ceruloplasmin	Homo sapiens	56-69
34975249-2	2021	The present cross-sectional study explored the role of hepcidin (HEP) in anemia of chronic disease in rheumatoid arthritis by studying its relationships with markers of anemia, iron metabolism, inflammation, and erythropoiesis.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	55-63
34975249-6	2021	Results HEP had statistically significant mostly moderate-to-large correlations with markers of anemia (0.30-0.70, all p < 0.01), small correlation with markers of iron metabolism and markers of inflammation ( r = 0.20-0.40, all p < 0.01), and moderate correlations with markers of erythropoiesis.	Iron	164-168	hepcidin antimicrobial peptide	Homo sapiens	8-11
34975249-10	2021	Conclusions HEP is related to markers of anemia, iron metabolism, inflammation, and erythropoiesis.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	12-15
16831606-1	2006	BACKGROUND &amp; AIMS: Aceruloplasminemia is a novel hereditary iron overload disease caused by a mutation in the ceruloplasmin gene and characterized by a complete deficiency of serum ceruloplasmin and iron accumulation in the liver and brain.	Iron	64-68	ceruloplasmin	Homo sapiens	24-37
16831606-1	2006	BACKGROUND &amp; AIMS: Aceruloplasminemia is a novel hereditary iron overload disease caused by a mutation in the ceruloplasmin gene and characterized by a complete deficiency of serum ceruloplasmin and iron accumulation in the liver and brain.	Iron	64-68	ceruloplasmin	Homo sapiens	114-127
34262329-1	2021	Background: Hepcidin plays an important role in iron homeostasis, inhibits intestinal iron absorption and iron release from hepatocytes and macrophages, while its clinical utility remained unclear.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	12-20
34262329-1	2021	Background: Hepcidin plays an important role in iron homeostasis, inhibits intestinal iron absorption and iron release from hepatocytes and macrophages, while its clinical utility remained unclear.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	12-20
34262329-1	2021	Background: Hepcidin plays an important role in iron homeostasis, inhibits intestinal iron absorption and iron release from hepatocytes and macrophages, while its clinical utility remained unclear.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	12-20
34262329-6	2021	The serum iron, serum ferritin, transferrin saturation (TSAT), and hsCRP were higher, pre-dialysis creatinine and albumin were lower, and the scores of health-related qualities of life were worse in the high-level hepcidin-25 group than in the low-level hepcidin-25 group.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	214-222
34100293-1	2021	Aim: To compare methods of quantifying serum hepcidin (based on MS and ELISA) and their ability to diagnose true iron deficiency anemia in critically ill patients.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	45-53
16707273-0	2006	Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF.	Iron	51-55	solute carrier family 11 member 2	Homo sapiens	19-23
34155415-0	2021	Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	0-8
16707273-0	2006	Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF.	Iron	51-55	HLF transcription factor, PAR bZIP family member	Homo sapiens	118-121
34155415-6	2021	Collectively, these data suggest that ectopic hepcidin in the tumour epithelium establishes an axis to sequester iron in order to maintain the nucleotide pool and sustain proliferation in colorectal tumours.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	46-54
34154323-0	2021	Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a (3Fe-4S) to a (4Fe-4S) Cluster in Dph1-Dph2.	Iron	62-66	Kti11p	Saccharomyces cerevisiae S288C	0-4
34154323-0	2021	Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a (3Fe-4S) to a (4Fe-4S) Cluster in Dph1-Dph2.	Iron	62-66	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	126-130
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	59-87
34154323-5	2021	Remarkably, the small iron-containing protein Dph3 donates one Fe atom to convert the (3Fe-4S) cluster in Dph1-Dph2 to a functional (4Fe-4S) cluster during the radical-SAM enzyme catalytic cycle.	Iron	22-26	Kti11p	Saccharomyces cerevisiae S288C	46-50
34154323-5	2021	Remarkably, the small iron-containing protein Dph3 donates one Fe atom to convert the (3Fe-4S) cluster in Dph1-Dph2 to a functional (4Fe-4S) cluster during the radical-SAM enzyme catalytic cycle.	Iron	22-26	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	111-115
34154323-5	2021	Remarkably, the small iron-containing protein Dph3 donates one Fe atom to convert the (3Fe-4S) cluster in Dph1-Dph2 to a functional (4Fe-4S) cluster during the radical-SAM enzyme catalytic cycle.	Iron	63-65	Kti11p	Saccharomyces cerevisiae S288C	46-50
34154323-5	2021	Remarkably, the small iron-containing protein Dph3 donates one Fe atom to convert the (3Fe-4S) cluster in Dph1-Dph2 to a functional (4Fe-4S) cluster during the radical-SAM enzyme catalytic cycle.	Iron	63-65	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	111-115
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	89-93
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	118-122	solute carrier family 11 member 2	Homo sapiens	59-87
34258058-0	2021	The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	24-32
16707273-2	2006	Dietary iron is transported into intestinal enterocytes by divalent metal transporter 1 (DMT1), which also transports iron from transferrin receptor 1 (TfR1)-mediated recycling endosome to intracytoplasm.	Iron	118-122	solute carrier family 11 member 2	Homo sapiens	89-93
34258058-4	2021	It is postulated that inflammation increases hepcidin, a regulator of iron homeostasis.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	45-53
16707273-3	2006	We made an antiserum against human DMT1 protein derived from mRNA with the iron responsive element (IRE).	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	35-39
34257829-7	2021	And we find that iron overload, one mechanism of ferroptosis, leads to mitochondrial permeability transition pore (MPTP) opening, which aggravates RIP1 phosphorylation and contributes to necroptosis.	Iron	17-21	receptor interacting serine/threonine kinase 1	Homo sapiens	147-151
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	13-17	HLF transcription factor, PAR bZIP family member	Homo sapiens	27-30
34161287-3	2021	Here, we report the identification of amino acid residues required for iron coordination on each structural domain of PCBP1 and confirm the requirement of iron coordination for binding target proteins BolA2 and ferritin.	Iron	155-159	bolA-like 2 (E. coli)	Mus musculus	201-206
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	13-17	solute carrier family 11 member 2	Homo sapiens	64-68
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	13-17	solute carrier family 11 member 2	Homo sapiens	137-141
34235338-2	2021	Complexation of Fe(BF4)2 6H2O with each ligand (H2 L1 and H4 L2) in a methanolic-pyridine solution resulted in hexa-iron compounds (C1 and C2, respectively), which each contain two near-parallel metal triangles of (Fe3-mu3-O), linked by six fluoride bridges and stabilized by a hydrogen-bonded proton between the mu3-O groups.	Iron	116-120	hexosaminidase subunit alpha	Homo sapiens	111-115
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	104-108	HLF transcription factor, PAR bZIP family member	Homo sapiens	27-30
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	64-68
34306369-10	2021	CONCLUSION: The HCV patients" serum hepcidin levels showed an abnormal decrease, suggesting that HCV patients may have an iron metabolism disorder, which indicates that there is a possibility of evaluating the HCV patients" conditions by measuring the hepcidin levels and of improving HCV patients" prognoses by regulating the iron metabolism.	Iron	327-331	hepcidin antimicrobial peptide	Homo sapiens	36-44
16707273-5	2006	In addition, iron-depleted HLF increased membrane expression of DMT1, suggesting that the intracellular iron concentration regulated the DMT1 expression in hepatocytes via the iron regulatory protein (IRP)/IRE system.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	137-141
34133924-5	2021	Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells.	Iron	50-54	glutathione peroxidase 4	Homo sapiens	90-94
16449358-1	2006	The H+-coupled polyligand transport protein divalent metal transporter 1 (DMT1) plays a key role in mammalian iron homeostasis.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	44-72
34207816-7	2021	Moreover, IS triggers eryptosis via ROS-mediated oxidative stress, and elevates hepcidin levels in order to prevent iron flux in circulation in renal anemia.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	80-88
16449358-1	2006	The H+-coupled polyligand transport protein divalent metal transporter 1 (DMT1) plays a key role in mammalian iron homeostasis.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	74-78
34163341-7	2021	Further, we have identified a new potential AD-related gene (MEF2C) closely related to the interaction between iron deposition and AD progression in the brain.	Iron	111-115	myocyte enhancer factor 2C	Homo sapiens	61-66
16457665-1	2006	Ferroportin [FPN; Slc40a1 (solute carrier family 40, member 1)] is a transmembrane iron export protein expressed in macrophages and duodenal enterocytes.	Iron	83-87	solute carrier family 40 member 1	Homo sapiens	18-25
34149342-2	2021	Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and CD228), a mammalian iron-transport protein, is an effective carrier for delivery of drug conjugates across the BBB into the brain and was the first BBB targeting delivery system to demonstrate therapeutic efficacy within the brain.	Iron	151-155	melanotransferrin	Homo sapiens	62-79
34149342-2	2021	Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and CD228), a mammalian iron-transport protein, is an effective carrier for delivery of drug conjugates across the BBB into the brain and was the first BBB targeting delivery system to demonstrate therapeutic efficacy within the brain.	Iron	151-155	melanotransferrin	Homo sapiens	116-119
34149342-2	2021	Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and CD228), a mammalian iron-transport protein, is an effective carrier for delivery of drug conjugates across the BBB into the brain and was the first BBB targeting delivery system to demonstrate therapeutic efficacy within the brain.	Iron	151-155	melanotransferrin	Homo sapiens	131-136
34073115-3	2021	We have previously developed micellar nanocarriers from Pluronic F68  (P68) and dequalinium (DQA) which have suitable characteristics for brain delivery of antioxidants and iron chelators.	Iron	173-177	DEAD-box helicase 5	Homo sapiens	56-68
16457665-1	2006	Ferroportin [FPN; Slc40a1 (solute carrier family 40, member 1)] is a transmembrane iron export protein expressed in macrophages and duodenal enterocytes.	Iron	83-87	solute carrier family 40 member 1	Homo sapiens	27-61
34073115-3	2021	We have previously developed micellar nanocarriers from Pluronic F68  (P68) and dequalinium (DQA) which have suitable characteristics for brain delivery of antioxidants and iron chelators.	Iron	173-177	DEAD-box helicase 5	Homo sapiens	71-74
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	24-28	leptin	Mus musculus	45-47
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	24-28	leptin	Mus musculus	48-50
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	24-28	leptin	Mus musculus	177-179
16711695-0	2006	Iron porphyrin-cyclodextrin supramolecular complex as a functional model of myoglobin in aqueous solution.	Iron	0-4	myoglobin	Homo sapiens	76-85
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	24-28	leptin	Mus musculus	180-182
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	72-76	leptin	Mus musculus	45-47
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	72-76	leptin	Mus musculus	48-50
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	72-76	leptin	Mus musculus	177-179
34064680-5	2021	In addition to muscular iron accumulation in ob/ob mice, expressions of iron homeostasis-related divalent metal transporter 1, ferritin, and hepcidin proteins were increased in ob/ob mice compared to lean littermates, whereas expressions of transferrin receptor and ferroportin were reduced.	Iron	72-76	leptin	Mus musculus	180-182
34065056-2	2021	Hepcidin is a hormone that regulates iron flow in plasma; its production is induced by an iron overload and by inflammation.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
34065056-2	2021	Hepcidin is a hormone that regulates iron flow in plasma; its production is induced by an iron overload and by inflammation.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
34065056-4	2021	Varied signals responding to iron stores, erythropoietic activity and host defense converge to regulate hepcidin production and thereby affect iron homeostasis.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	104-112
16434484-5	2006	Increased serum concentrations of the hepcidin precursor prohepcidin were paralleled by a decreased expression of the iron exporter ferroportin in circulating monocytes of ACD patients.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	38-46
34065056-4	2021	Varied signals responding to iron stores, erythropoietic activity and host defense converge to regulate hepcidin production and thereby affect iron homeostasis.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	104-112
34065122-14	2021	Finally, a significant reduction in MIN6 beta-cell SNAP-25 protein expression was evident at 48 h upon exposure to 100 microM iron.	Iron	126-130	synaptosomal-associated protein 25	Mus musculus	51-58
34187283-6	2021	We report a 10-year-old boy with beta-TM who died with clinical possibilities of iron overload-related cardiac failure and pulmonary arterial hypertension.	Iron	81-85	ATM serine/threonine kinase	Homo sapiens	33-40
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	215-217	H2B clustered histone 21	Homo sapiens	117-120
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	215-217	secreted phosphoprotein 1	Homo sapiens	218-222
16533814-5	2006	The purified human recombinant DOHH was a mixture of active holoenzyme containing 2 mol of iron/mol of DOHH and inactive metal-free apoenzyme.	Iron	91-95	deoxyhypusine hydroxylase	Homo sapiens	31-35
34180415-0	2021	Upregulation of Local Hepcidin Contributes to Iron Accumulation in Alzheimer"s Disease Brains.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	22-30
34180415-3	2021	OBJECTIVE: To explore whether local hepcidin synthesized by brain cells contributes to iron accumulation in AD brains.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	36-44
34180415-13	2021	The increase in hepcidin is disease-specific, and increases with disease progression, implicating AD-specific pathology in the accumulation of iron.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	16-24
16533814-7	2006	The DOHH apoenzyme exhibited markedly reduced levels of iron and activity.	Iron	56-60	deoxyhypusine hydroxylase	Homo sapiens	4-8
35593209-3	2022	PICOT is now believed to act as a chaperone distributing Fe-S clusters, although the first link to iron metabolism was observed with its yeast counterparts.	Iron	57-59	glutaredoxin 3	Homo sapiens	0-5
35593209-3	2022	PICOT is now believed to act as a chaperone distributing Fe-S clusters, although the first link to iron metabolism was observed with its yeast counterparts.	Iron	99-103	glutaredoxin 3	Homo sapiens	0-5
16533814-13	2006	Furthermore, the iron to DOHH stoichiometry and dependence of iron binding on each of the four conserved His-Glu motifs suggest a binuclear iron mediated reaction mechanism, distinct from that of other Fe(II)-dependent protein hydroxylases, such as prolyl 4-hydroxylase or lysyl hydroxylases.	Iron	17-21	deoxyhypusine hydroxylase	Homo sapiens	25-29
35593209-4	2022	Like PICOT, yeast Grx3 and Grx4 reside in the cytosol and nucleus where they form unusual Fe-S clusters coordinated by two glutaredoxins with CGFS motifs and two molecules of glutathione.	Iron	90-92	glutaredoxin 3	Homo sapiens	5-10
35593209-8	2022	Adopting a high copy-number library screen approach, we discovered novel genetic interactions: overexpression of ESL1, ESL2, SOK1, SFP1 or BDF2 partially rescues growth and iron utilization defects of Deltagrx3/4.	Iron	173-177	Sok1p	Saccharomyces cerevisiae S288C	125-129
35593209-8	2022	Adopting a high copy-number library screen approach, we discovered novel genetic interactions: overexpression of ESL1, ESL2, SOK1, SFP1 or BDF2 partially rescues growth and iron utilization defects of Deltagrx3/4.	Iron	173-177	zinc-coordinating transcription factor SFP1	Saccharomyces cerevisiae S288C	131-135
16584902-0	2006	A novel R416C mutation in human DMT1 (SLC11A2) displays pleiotropic effects on function and causes microcytic anemia and hepatic iron overload.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	32-36
35304178-4	2022	A Fe/Cu proportion of 2/1 (FCC-2/1) was determined to be the optimum proportion for antimony adsorption, specifically 34.5 mg g-1 for Sb(III) and 26.8 mg g-1 for Sb(V) (initial concentration: 5.0 mg L-1).	Iron	2-4	mutL homolog 1	Homo sapiens	27-34
35583462-1	2022	Owing to having a unique mechanism to kill cancer cells via the membrane accumulation of lipid peroxide (LPO) and the downregulation of glutathione peroxidase-4 (GPX-4), the ferroptosis therapy (FT) of tumors based on the Fenton reaction of iron nanoparticles has been receiving much attention in the past decade; however, there are some hurdles including the uncontrollable release of iron ions, slower kinetics of the intracellular Fenton reaction, and poor efficacy of FT that need to be overcome.	Iron	241-245	glutathione peroxidase 4	Homo sapiens	136-160
35583462-1	2022	Owing to having a unique mechanism to kill cancer cells via the membrane accumulation of lipid peroxide (LPO) and the downregulation of glutathione peroxidase-4 (GPX-4), the ferroptosis therapy (FT) of tumors based on the Fenton reaction of iron nanoparticles has been receiving much attention in the past decade; however, there are some hurdles including the uncontrollable release of iron ions, slower kinetics of the intracellular Fenton reaction, and poor efficacy of FT that need to be overcome.	Iron	241-245	glutathione peroxidase 4	Homo sapiens	162-167
16584902-0	2006	A novel R416C mutation in human DMT1 (SLC11A2) displays pleiotropic effects on function and causes microcytic anemia and hepatic iron overload.	Iron	129-133	solute carrier family 11 member 2	Homo sapiens	38-45
35583462-1	2022	Owing to having a unique mechanism to kill cancer cells via the membrane accumulation of lipid peroxide (LPO) and the downregulation of glutathione peroxidase-4 (GPX-4), the ferroptosis therapy (FT) of tumors based on the Fenton reaction of iron nanoparticles has been receiving much attention in the past decade; however, there are some hurdles including the uncontrollable release of iron ions, slower kinetics of the intracellular Fenton reaction, and poor efficacy of FT that need to be overcome.	Iron	386-390	glutathione peroxidase 4	Homo sapiens	136-160
35583462-1	2022	Owing to having a unique mechanism to kill cancer cells via the membrane accumulation of lipid peroxide (LPO) and the downregulation of glutathione peroxidase-4 (GPX-4), the ferroptosis therapy (FT) of tumors based on the Fenton reaction of iron nanoparticles has been receiving much attention in the past decade; however, there are some hurdles including the uncontrollable release of iron ions, slower kinetics of the intracellular Fenton reaction, and poor efficacy of FT that need to be overcome.	Iron	386-390	glutathione peroxidase 4	Homo sapiens	162-167
35583462-2	2022	Considering cooperative coordination of a multivalent thiol-pendant polypeptide ligand with iron ions, we put forward a facile strategy for constructing the iron-coordinated nanohybrid of methacryloyloxyethyl phosphorylcholine-grafted polycysteine/iron ions/tannic acid (i.e., PCFT), which could deliver a higher concentration of iron ions into cells.	Iron	92-96	solute carrier family 46 member 1	Homo sapiens	277-281
35583462-2	2022	Considering cooperative coordination of a multivalent thiol-pendant polypeptide ligand with iron ions, we put forward a facile strategy for constructing the iron-coordinated nanohybrid of methacryloyloxyethyl phosphorylcholine-grafted polycysteine/iron ions/tannic acid (i.e., PCFT), which could deliver a higher concentration of iron ions into cells.	Iron	157-161	solute carrier family 46 member 1	Homo sapiens	277-281
35583462-2	2022	Considering cooperative coordination of a multivalent thiol-pendant polypeptide ligand with iron ions, we put forward a facile strategy for constructing the iron-coordinated nanohybrid of methacryloyloxyethyl phosphorylcholine-grafted polycysteine/iron ions/tannic acid (i.e., PCFT), which could deliver a higher concentration of iron ions into cells.	Iron	248-252	solute carrier family 46 member 1	Homo sapiens	277-281
35583462-2	2022	Considering cooperative coordination of a multivalent thiol-pendant polypeptide ligand with iron ions, we put forward a facile strategy for constructing the iron-coordinated nanohybrid of methacryloyloxyethyl phosphorylcholine-grafted polycysteine/iron ions/tannic acid (i.e., PCFT), which could deliver a higher concentration of iron ions into cells.	Iron	330-334	solute carrier family 46 member 1	Homo sapiens	277-281
35470077-0	2022	Iron ion and sulfasalazine-loaded polydopamine nanoparticles for Fenton reaction and glutathione peroxidase 4 inactivation for enhanced cancer ferrotherapy.	Iron	0-4	glutathione peroxidase 4	Homo sapiens	85-109
16584902-1	2006	A patient suffering from microcytic anemia and hepatic iron overload was found to be compound heterozygote for polymorphisms in the iron transporter DMT1 (Nramp2, SLC11A2), including a 3-bp deletion (DMT1(delCTT)) in intron 4 that partially impairs splicing and an amino acid substitution (DMT1(C1246T), R416C) at a conserved residue in transmembrane domain 9 of the protein.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	149-153
35490984-12	2022	RESULTS: We found that the expressions of LIP ROS, ROS, COX2, MDA and other oxidative factors increased, while the antioxidant markers GPX4, GSH and GSH-Px significantly decreased, as well as active iron accumulation in COPD patients, PM-exposured WT and Nrf2-KO mice models and PM2.5-mediated cell models.	Iron	199-203	glutathione peroxidase 4	Homo sapiens	135-139
16584902-1	2006	A patient suffering from microcytic anemia and hepatic iron overload was found to be compound heterozygote for polymorphisms in the iron transporter DMT1 (Nramp2, SLC11A2), including a 3-bp deletion (DMT1(delCTT)) in intron 4 that partially impairs splicing and an amino acid substitution (DMT1(C1246T), R416C) at a conserved residue in transmembrane domain 9 of the protein.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	155-161
16584902-1	2006	A patient suffering from microcytic anemia and hepatic iron overload was found to be compound heterozygote for polymorphisms in the iron transporter DMT1 (Nramp2, SLC11A2), including a 3-bp deletion (DMT1(delCTT)) in intron 4 that partially impairs splicing and an amino acid substitution (DMT1(C1246T), R416C) at a conserved residue in transmembrane domain 9 of the protein.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	163-170
35217337-1	2022	BACKGROUND: Hepcidin is the master iron regulator hormone produced by the liver.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	12-20
35567291-10	2022	In addition, knockdown of MIF and SLC3A2 promoted iron death in SW480 and SW620 cells.	Iron	50-54	solute carrier family 3 member 2	Homo sapiens	34-40
16584902-1	2006	A patient suffering from microcytic anemia and hepatic iron overload was found to be compound heterozygote for polymorphisms in the iron transporter DMT1 (Nramp2, SLC11A2), including a 3-bp deletion (DMT1(delCTT)) in intron 4 that partially impairs splicing and an amino acid substitution (DMT1(C1246T), R416C) at a conserved residue in transmembrane domain 9 of the protein.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	200-204
16584902-1	2006	A patient suffering from microcytic anemia and hepatic iron overload was found to be compound heterozygote for polymorphisms in the iron transporter DMT1 (Nramp2, SLC11A2), including a 3-bp deletion (DMT1(delCTT)) in intron 4 that partially impairs splicing and an amino acid substitution (DMT1(C1246T), R416C) at a conserved residue in transmembrane domain 9 of the protein.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	200-204
35447413-8	2022	Accumulation of SLC7A11 increases the level of l-Glutathione (GSH) and inhibits the accumulation of reactive oxygen species (ROS) and irons in the GC cells.	Iron	134-139	solute carrier family 7 member 11	Homo sapiens	16-23
16584902-5	2006	We propose that DMT1(C1246T) (R416C) represents a complete loss-of-function, and that a quantitative reduction in DMT1 expression is the cause of the microcytic anemia and iron overload in the patient.	Iron	172-176	solute carrier family 11 member 2	Homo sapiens	114-118
16614410-3	2006	The copper requirement of the multicopper ferroxidases hephaestin and ceruloplasmin likely explains this link between copper and iron homeostasis in mammals.	Iron	129-133	ceruloplasmin	Mus musculus	70-83
35618957-3	2022	The second transferrin receptor, an iron sensor both in the liver and in erythroid cells modulates erythropoietin sensitivity and is a further link between hepcidin and erythropoiesis.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	156-164
35618957-5	2022	A deranged balance between erythropoiesis and iron/hepcidin may lead to anemia, as in the case of iron deficiency, defective iron uptake and erythroid utilization or subnormal recycling.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	51-59
35618957-5	2022	A deranged balance between erythropoiesis and iron/hepcidin may lead to anemia, as in the case of iron deficiency, defective iron uptake and erythroid utilization or subnormal recycling.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	51-59
35618957-6	2022	Defective control of hepcidin production may cause iron deficiency, as in the recessive disorder iron refractory iron deficiency anemia or in anemia of inflammation, or in iron loading anemias, which are characterized by excessive but ineffective erythropoiesis.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	21-29
16362328-6	2006	FRO3 is expressed at high levels in roots and shoots, and expression of FRO3 is elevated in roots and shoots of iron-deficient plants.	Iron	112-116	ferric reduction oxidase 3	Arabidopsis thaliana	72-76
35605088-2	2022	Lactoferrin (LF) is an iron binding protein with anti-inflammatory and antioxidant effects.	Iron	23-27	lactotransferrin	Rattus norvegicus	0-11
16755911-3	2006	Recently, several lines of evidence have suggested that hepcidin is a key regulator of iron metabolism at the whole body level and is relative to inflammation, infection, hypoxia and anemia.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	56-64
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	157-161	heme oxygenase 1	Homo sapiens	60-64
35631257-2	2022	Patients" inflammatory status is strictly related to the occurrence of functional iron deficiency anemia (IDA) because this causes an increase in hepcidin levels with the consequent inhibition of iron absorption and release from cellular stores into blood circulation.	Iron	196-200	hepcidin antimicrobial peptide	Homo sapiens	146-154
35580554-2	2022	Hepcidin, encoded by the HAMP gene, affects inflammation, and iron homeostasis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
35580554-2	2022	Hepcidin, encoded by the HAMP gene, affects inflammation, and iron homeostasis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	25-29
35580554-6	2022	Moreover, hepcidin decreased iron uptake, as determined by Transferrin Receptor (TfR1) expression levels, and increased iron storage, based on ferritin heavy chain (FTH) expression.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	10-18
35580554-6	2022	Moreover, hepcidin decreased iron uptake, as determined by Transferrin Receptor (TfR1) expression levels, and increased iron storage, based on ferritin heavy chain (FTH) expression.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	10-18
35304126-8	2022	Furthermore, forward and reverse validation experiments demonstrated that six-transmembrane epithelial antigen of prostate 3 (STEAP3), a new interacting molecule for ISCA1, plays an important role in iron metabolism and energy generation impairment induced by ISCA1 deficiency.	Iron	200-204	STEAP3 metalloreductase	Rattus norvegicus	74-124
35304126-8	2022	Furthermore, forward and reverse validation experiments demonstrated that six-transmembrane epithelial antigen of prostate 3 (STEAP3), a new interacting molecule for ISCA1, plays an important role in iron metabolism and energy generation impairment induced by ISCA1 deficiency.	Iron	200-204	STEAP3 metalloreductase	Rattus norvegicus	126-132
16755911-4	2006	Hepcidin, is implicated in duodenal iron absorption and iron mobilization from reticuloendothelial macrophages.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
16755911-4	2006	Hepcidin, is implicated in duodenal iron absorption and iron mobilization from reticuloendothelial macrophages.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
35576847-2	2022	Hepcidin, as a peptide hormone, plays a vital role in regulating systemic iron homeostasis.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	0-8
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	interleukin 1 alpha	Mus musculus	143-151
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	glutathione peroxidase 1	Mus musculus	225-229
16755911-5	2006	The major mechanism of hepcidin function seems to be the regulation of transmembrane iron transport.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	23-31
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	glutathione peroxidase 4	Mus musculus	231-235
16631522-7	2006	Intracellular free iron determined with the fluorescent probe calcein rose to approximately 160% of the control level 6 h after SPNO, but declined to approximately 70% after 24 h. Immunoblot analyses revealed a rapid early (approximately 2 h post-NO) increase in heme oxygenase-1 level, followed by a gradual (4-20 h post-NO) increase in ferritin.	Iron	19-23	heme oxygenase 1	Homo sapiens	263-279
35578731-3	2022	In this sense, the hydrogen content of coke oven gas (COG) has positioned it as a promising source toward a hydrogen-based economy which could lead to economic and environmental benefits in the iron and steel industry.	Iron	194-198	gastrin	Homo sapiens	49-52
16364543-6	2006	Since the two HSP108 peaks appeared to be correlated with the transferrin expression peaks during retinal development, HSP108 may be associated with iron metabolism during the development of the retina.	Iron	149-153	heat shock protein 90 beta family member 1	Gallus gallus	119-125
35600142-7	2022	Eventually, we analyzed the interactions of free and bound forms of spike with hepcidin (HPC), the major hormone in iron regulation, recently addressed as a central player in the COVID19 pathogenesis, with a special emphasis to the most severe outcomes.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	79-87
35628152-2	2022	In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a considerable amount of iron is required daily for hemoglobin synthesis and erythroid cell proliferation.	Iron	63-67	myoglobin	Homo sapiens	52-61
16529490-5	2006	In contrast, 3 with {M(PPh3)}+ gives the trimetallic species [1,3,4,9-{MFe(CO)4(PPh3)}-1,3-(mu-H)2-9,9,9-(CO)3-arachno-9,6-FeCB8H9] (M = Cu (7), Ag 8) in which the three metal centers form a V-shaped M-Fe-Fe unit.	Iron	72-74	protein phosphatase 4 catalytic subunit	Homo sapiens	23-27
35579155-5	2022	Meantime, immune cells release immunostimulatory cytokines including TNF-alpha and IFN-gamma to downregulate the expression of SLC7A11 and SLC3A2, and reduce the absorption of cysteine, leading to lipid peroxidation and iron deposition in cancer cells.	Iron	220-224	solute carrier family 7 member 11	Homo sapiens	127-134
35438990-3	2022	Reduction of this precursor using excess sodium amalgam afforded (Ph2PPrPDI)Fe, which possesses an Fe(II) center that is supported by a dianionic PDI ligand.	Iron	76-78	peptidyl arginine deiminase 1	Homo sapiens	146-149
16529490-5	2006	In contrast, 3 with {M(PPh3)}+ gives the trimetallic species [1,3,4,9-{MFe(CO)4(PPh3)}-1,3-(mu-H)2-9,9,9-(CO)3-arachno-9,6-FeCB8H9] (M = Cu (7), Ag 8) in which the three metal centers form a V-shaped M-Fe-Fe unit.	Iron	72-74	protein phosphatase 4 catalytic subunit	Homo sapiens	80-84
35202704-2	2022	Retinal iron overload has been reported in several mouse disease models with systemic or neural retina-specific knockout (KO) of homologous ferroxidases ceruloplasmin (Cp) and hephaestin (Heph).	Iron	8-12	ceruloplasmin	Mus musculus	153-166
16529490-5	2006	In contrast, 3 with {M(PPh3)}+ gives the trimetallic species [1,3,4,9-{MFe(CO)4(PPh3)}-1,3-(mu-H)2-9,9,9-(CO)3-arachno-9,6-FeCB8H9] (M = Cu (7), Ag 8) in which the three metal centers form a V-shaped M-Fe-Fe unit.	Iron	123-125	protein phosphatase 4 catalytic subunit	Homo sapiens	23-27
35337799-5	2022	Moreover, we found that a decrease of glutathione peroxidase 4 (GPX4) due to iron accumulation promotes ferroptosis.	Iron	77-81	glutathione peroxidase 4	Homo sapiens	38-62
16529490-5	2006	In contrast, 3 with {M(PPh3)}+ gives the trimetallic species [1,3,4,9-{MFe(CO)4(PPh3)}-1,3-(mu-H)2-9,9,9-(CO)3-arachno-9,6-FeCB8H9] (M = Cu (7), Ag 8) in which the three metal centers form a V-shaped M-Fe-Fe unit.	Iron	123-125	protein phosphatase 4 catalytic subunit	Homo sapiens	80-84
35337799-5	2022	Moreover, we found that a decrease of glutathione peroxidase 4 (GPX4) due to iron accumulation promotes ferroptosis.	Iron	77-81	glutathione peroxidase 4	Homo sapiens	64-68
35490179-9	2022	Taken together, these findings demonstrate that OTUD3 is a bona fide deubiquitylase for IRP2 and plays a critical role in the nigral iron deposits in PD.	Iron	133-137	OTU deubiquitinase 3	Homo sapiens	48-53
16509583-7	2006	A related docking study of 13e in the 15-LOX binding site indicates that the C-3 p-SO2Me COX-2 pharmacophore was positioned in a region closer to the catalytic iron site where it undergoes a hydrogen bonding interaction with His541 and His366, and that the C-1 p-i-Pr substituent is buried deep in a hydrophobic pocket (Ile414, Ile418, Met419 and Ile593) near the base of the 15-LOX binding site.	Iron	160-164	arachidonate 15-lipoxygenase	Rattus norvegicus	38-44
35477031-2	2022	AIM: To evaluate a non-invasive method for assessing mild iron overload in patients with NAFLD using 3T magnetic resonance imaging (MRI) relaxometry, serum hepcidin, and the expression of ferritin subunits.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	156-164
16511496-8	2006	Disruption of the yeast mfrn orthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis.	Iron	75-79	Fe(2+) transporter	Saccharomyces cerevisiae S288C	51-55
35557955-1	2022	Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated (2Fe-2S) cluster.	Iron	72-76	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	29-34
35557955-1	2022	Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated (2Fe-2S) cluster.	Iron	72-76	CDGSH iron sulfur domain 1	Homo sapiens	39-47
35460388-4	2022	Hepcidin is a key regulator of systemic iron balance and acts in harmony with intracellular iron metabolism.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	0-8
16511496-8	2006	Disruption of the yeast mfrn orthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis.	Iron	109-113	Fe(2+) transporter	Saccharomyces cerevisiae S288C	51-55
16461755-1	2006	Heme oxygenase 1 (HO-1) is induced in response to cellular stress and is responsible for converting the prooxidant heme molecule into equimolar quantities of biliverdin (BV), carbon monoxide (CO), and iron.	Iron	201-205	heme oxygenase 1	Homo sapiens	0-16
35565198-10	2022	We suggest that 8-oxo-dG accumulates following increased oxidative stress due to hepatic tissue iron deposition; this may activate Wnt/beta-catenin signaling and trigger carcinogenesis.	Iron	96-100	catenin beta 1	Homo sapiens	135-147
35631320-12	2022	Among products of HO-1 catalyzed heme degradation iron mimicked the anti-calcification effect of heme.	Iron	50-54	heme oxygenase 1	Homo sapiens	18-22
35631320-13	2022	We concluded that heme-induced upregulation of the Nrf2/HO-1 system inhibits HuLECs calcification through the liberation of heme iron.	Iron	129-133	heme oxygenase 1	Homo sapiens	56-60
35457224-2	2022	DMT1 has a vital role in iron homeostasis by mediating iron uptake in the intestine and kidneys and by recovering iron from recycling endosomes after transferrin endocytosis.	Iron	25-29	solute carrier family 11 member 2	Homo sapiens	0-4
35457224-2	2022	DMT1 has a vital role in iron homeostasis by mediating iron uptake in the intestine and kidneys and by recovering iron from recycling endosomes after transferrin endocytosis.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	0-4
35457224-2	2022	DMT1 has a vital role in iron homeostasis by mediating iron uptake in the intestine and kidneys and by recovering iron from recycling endosomes after transferrin endocytosis.	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	0-4
35457224-3	2022	Mutations in SLC11A2 cause an ultra-rare hypochromic microcytic anemia with iron overload (AHMIO1), which has been described in eight patients so far.	Iron	76-80	solute carrier family 11 member 2	Homo sapiens	13-20
16461755-1	2006	Heme oxygenase 1 (HO-1) is induced in response to cellular stress and is responsible for converting the prooxidant heme molecule into equimolar quantities of biliverdin (BV), carbon monoxide (CO), and iron.	Iron	201-205	heme oxygenase 1	Homo sapiens	18-22
35457224-3	2022	Mutations in SLC11A2 cause an ultra-rare hypochromic microcytic anemia with iron overload (AHMIO1), which has been described in eight patients so far.	Iron	76-80	solute carrier family 11 member 2	Homo sapiens	91-97
16222706-2	2006	Up-regulation of HO-1 in rat astroglia has been shown to facilitate iron sequestration by the mitochondrial compartment.	Iron	68-72	heme oxygenase 1	Homo sapiens	17-21
35399101-7	2022	Knockdown of MALAT1 significantly aggravated the inhibition of cell viability and increased intracellular iron, Liperfluo, and MDA levels in EESCs upon erastin treatment.	Iron	106-110	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	13-19
16222706-9	2006	Glial HO-1 hyperactivity may contribute to cellular oxidative stress, pathological iron deposition, and bioenergetic failure characteristic of degenerating and inflamed neural tissues and may constitute a rational target for therapeutic intervention in these conditions.	Iron	83-87	heme oxygenase 1	Homo sapiens	6-10
16461380-1	2006	AtATM3, an ATP-binding cassette transporter of Arabidopsis (Arabidopsis thaliana), is a mitochondrial protein involved in the biogenesis of iron-sulfur clusters and iron homeostasis in plants.	Iron	165-169	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	0-6
35148994-8	2022	An Fe-S cluster in HBx offers new insights into its previously unknown molecular properties and sets the stage for deciphering the roles of HBx-associated iron (mis)regulation and reactive oxygen species in the context of liver tumorigenesis.	Iron	155-159	X protein	Hepatitis B virus	19-22
35148994-8	2022	An Fe-S cluster in HBx offers new insights into its previously unknown molecular properties and sets the stage for deciphering the roles of HBx-associated iron (mis)regulation and reactive oxygen species in the context of liver tumorigenesis.	Iron	155-159	X protein	Hepatitis B virus	140-143
16433545-0	2006	Catalytic mechanism and product specificity of the histone lysine methyltransferase SET7/9: an ab initio QM/MM-FE study with multiple initial structures.	Iron	111-113	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	84-90
16267047-0	2006	Two isoforms of a divalent metal transporter (DMT1) in Schistosoma mansoni suggest a surface-associated pathway for iron absorption in schistosomes.	Iron	116-120	solute carrier family 11 member 2	Homo sapiens	46-50
16267047-6	2006	An iron-responsive element, present at the 3"-untranslated region of many DMT1 molecules, is not present in schistosome mRNAs studied here.	Iron	3-7	solute carrier family 11 member 2	Homo sapiens	74-78
16321355-1	2006	Ceruloplasmin has ferroxidase activity and plays an essential role in iron metabolism.	Iron	70-74	ceruloplasmin	Homo sapiens	0-13
16341090-4	2006	Incorporation of iron into the Fe/S protein Leu1 and formation of the Fe/S cluster containing holoform of the mitochondrial ferredoxin Yah1 were inhibited in the absence of Isd11.	Iron	17-21	adrenodoxin	Saccharomyces cerevisiae S288C	135-139
21949961-0	2006	The scientific writings of Tom Bothwell and his contribution to iron metabolism.	Iron	64-68	pre-mRNA processing factor 6	Homo sapiens	27-30
16400057-6	2006	Iron-free, apo-soybean ferritin was prepared (with the use of thioglycolic acid and extensive dialysis) from purified ferritin.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	23-31
16400057-6	2006	Iron-free, apo-soybean ferritin was prepared (with the use of thioglycolic acid and extensive dialysis) from purified ferritin.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	118-126
16400057-8	2006	The subjects received 140 microg Fe as ferritin (2.5 mg) or as FeSO4.	Iron	33-35	ferritin-1, chloroplastic	Glycine max	39-47
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	60-64	ferritin-1, chloroplastic	Glycine max	47-55
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	60-64	ferritin-1, chloroplastic	Glycine max	86-94
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	60-64	ferritin-1, chloroplastic	Glycine max	86-94
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	47-55
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	86-94
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	86-94
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	47-55
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	86-94
16400057-11	2006	An inverse relation was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as ferrous salts or as ferritin mineral.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	86-94
16400057-12	2006	CONCLUSION: Iron from soybean ferritin is well absorbed and may provide a model for novel, utilizable, plant-based forms of iron for populations with a low iron status.	Iron	12-16	ferritin-1, chloroplastic	Glycine max	30-38
16400057-12	2006	CONCLUSION: Iron from soybean ferritin is well absorbed and may provide a model for novel, utilizable, plant-based forms of iron for populations with a low iron status.	Iron	124-128	ferritin-1, chloroplastic	Glycine max	30-38
16400057-12	2006	CONCLUSION: Iron from soybean ferritin is well absorbed and may provide a model for novel, utilizable, plant-based forms of iron for populations with a low iron status.	Iron	156-160	ferritin-1, chloroplastic	Glycine max	30-38
16848707-4	2006	Hepcidin, the iron hormone, seems to hold a central pathogenic place in hemochromatosis, similar to insulin in diabetes: Genetically determined lack of hepcidin synthesis or activity may cause the disease.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	0-8
16848710-0	2006	Regulation of iron metabolism by hepcidin.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	33-41
16848710-1	2006	Hepcidin, a peptide hormone made in the liver, is the principal regulator of systemic iron homeostasis.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	0-8
35443540-3	2022	RET-He measure the recent functional availability of iron and the correlation well with iron deficient / restricted erythropoiesis, and it is not affected by infection and inflammation related to cancer so it can be useful marker to rapidly rule out iron deficiency in cancer patients.	Iron	53-57	ret proto-oncogene	Homo sapiens	0-3
35443540-3	2022	RET-He measure the recent functional availability of iron and the correlation well with iron deficient / restricted erythropoiesis, and it is not affected by infection and inflammation related to cancer so it can be useful marker to rapidly rule out iron deficiency in cancer patients.	Iron	88-92	ret proto-oncogene	Homo sapiens	0-3
16848710-2	2006	Hepcidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
35443540-10	2022	Observation: At a cut off of 28.4 pg, RET-He achieved sensitivity of 96.77 % and specificity of 81.66% with NPV of 99.3% and PPV of 49.2% for iron deficient state in cancer patients.	Iron	142-146	ret proto-oncogene	Homo sapiens	38-41
35443540-13	2022	Conclusion: RET-He is better indicator of IDA in cancer patients as compared to other conventional methods of diagnosing IDA.This study also revealed a direct correlation between RET-He and bone marrow iron stores.	Iron	202-206	ret proto-oncogene	Homo sapiens	12-15
35443540-13	2022	Conclusion: RET-He is better indicator of IDA in cancer patients as compared to other conventional methods of diagnosing IDA.This study also revealed a direct correlation between RET-He and bone marrow iron stores.	Iron	202-206	ret proto-oncogene	Homo sapiens	179-182
35131600-4	2022	Peroxisome proliferator-activated receptor gamma (PPARgamma) transcribed Ltf and the lack of neutrophilic Ltf transcription and secretion exacerbated neuronal ferroptosis by accumulating intraneuronal iron.	Iron	201-205	lactotransferrin	Mus musculus	106-109
16848710-2	2006	Hepcidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
16848710-2	2006	Hepcidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
35447901-0	2022	Salmon Protein Hydrolysate Potentiates the Growth Inhibitory Effect of Bicalutamide on Human Prostate Cancer Cell Lines LNCaP and PC3 by Modulating Iron Homeostasis.	Iron	148-152	proprotein convertase subtilisin/kexin type 1	Homo sapiens	130-133
16848710-2	2006	Hepcidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
35402284-7	2022	Furthermore, we revealed that PCAT1 inhibited ferroptosis by activating solute carrier family 7-member 11 (SLC7A11) expression via reducing iron accumulation and subsequent oxidative damage.	Iron	140-144	solute carrier family 7 member 11	Homo sapiens	72-105
16848710-2	2006	Hepcidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
35402284-7	2022	Furthermore, we revealed that PCAT1 inhibited ferroptosis by activating solute carrier family 7-member 11 (SLC7A11) expression via reducing iron accumulation and subsequent oxidative damage.	Iron	140-144	solute carrier family 7 member 11	Homo sapiens	107-114
16848710-3	2006	Hepcidin acts by inhibiting cellular iron efflux through binding to and inducing the degradation of ferroportin, the sole known cellular iron exporter.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
16848710-3	2006	Hepcidin acts by inhibiting cellular iron efflux through binding to and inducing the degradation of ferroportin, the sole known cellular iron exporter.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	0-8
35391749-3	2022	Amyloid precursor protein (APP) and tau protein, both of which are related to the AD pathogenesis, are associated with brain iron metabolism.	Iron	125-129	microtubule associated protein tau	Homo sapiens	36-39
35391749-5	2022	Amyloid beta (Abeta) and hyperphosphorylated tau, two pathological hallmarks of AD, can also promote iron deposition in the brain, forming a vicious cycle of AD development-iron deposition.	Iron	101-105	microtubule associated protein tau	Homo sapiens	45-48
35391749-5	2022	Amyloid beta (Abeta) and hyperphosphorylated tau, two pathological hallmarks of AD, can also promote iron deposition in the brain, forming a vicious cycle of AD development-iron deposition.	Iron	173-177	microtubule associated protein tau	Homo sapiens	45-48
35191669-6	2022	Initially, d-Pen reacts with native catalase and/or iron metal ions, used to mimic non-heme iron overload observed in long-term treated WD patients, to generate thiyl radicals.	Iron	52-62	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	13-16
35191669-6	2022	Initially, d-Pen reacts with native catalase and/or iron metal ions, used to mimic non-heme iron overload observed in long-term treated WD patients, to generate thiyl radicals.	Iron	92-96	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	13-16
16848710-4	2006	Synthesis of hepcidin is homeostatically increased by iron loading and decreased by anemia and hypoxia.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	13-21
35038358-5	2022	Consistently, the rescue effects of dZIP13 OE or Tsf1 RNAi on Pink1 RNAi can be inhibited by decreasing the iron levels in mitochondria through mitoferrin (dmfrn) RNAi.	Iron	108-112	PTEN-induced putative kinase 1	Drosophila melanogaster	62-67
35038358-6	2022	This study suggests that dZIP13, Tsf1 and dmfrn might act independently of parkin in a parallel pathway downstream of Pink1 by modulating respiration and indicates that manipulation of iron levels in mitochondria may provide a novel therapeutic strategy for PD associated with Pink1.	Iron	185-189	PTEN-induced putative kinase 1	Drosophila melanogaster	118-123
35038358-6	2022	This study suggests that dZIP13, Tsf1 and dmfrn might act independently of parkin in a parallel pathway downstream of Pink1 by modulating respiration and indicates that manipulation of iron levels in mitochondria may provide a novel therapeutic strategy for PD associated with Pink1.	Iron	185-189	PTEN-induced putative kinase 1	Drosophila melanogaster	277-282
16848710-5	2006	Hepcidin is also elevated during infections and inflammation, causing a decrease in serum iron levels and contributing to the development of anemia of inflammation, probably as a host defense mechanism to limit the availability of iron to invading microorganisms.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
16848710-5	2006	Hepcidin is also elevated during infections and inflammation, causing a decrease in serum iron levels and contributing to the development of anemia of inflammation, probably as a host defense mechanism to limit the availability of iron to invading microorganisms.	Iron	231-235	hepcidin antimicrobial peptide	Homo sapiens	0-8
16848710-7	2006	The emergence of hepcidin as the pathogenic factor in most systemic iron disorders should provide important opportunities for improving their diagnosis and treatment.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	17-25
35210360-6	2022	COA7 binds heme with micromolar affinity, through axial ligation to the central iron atom by histidine and methionine residues.	Iron	80-84	cytochrome c oxidase assembly factor 7	Homo sapiens	0-4
16160008-0	2006	Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2).	Iron	30-34	solute carrier family 11 member 2	Homo sapiens	95-99
35175757-7	2022	Such a trend is also confirmed by the X-ray structure of the direduced compound (Au{eta1-Fe2(CO)8}{eta2-Fe2(CO)6(mu-CO)2})3-, featuring the cleavage of one Au-Fe bond.	Iron	159-161	secreted phosphoprotein 1	Homo sapiens	84-88
35269771-5	2022	We analysed the protein expression levels of signalling molecules regulated by CX3CR1 as well as hepcidin, the major iron regulatory hormone, the iron transporters, the iron storage proteins and mitochondrial iron utilization.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	97-105
16160008-1	2006	Divalent metal transporter 1 (DMT1) mediates apical iron uptake in duodenal enterocytes and iron transfer from the transferrin receptor endosomal cycle into the cytosol in erythroid cells.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	0-28
35211089-1	2021	Hepcidin is a protein responsible for maintaining iron (Fe) homeostasis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
35211089-1	2021	Hepcidin is a protein responsible for maintaining iron (Fe) homeostasis.	Iron	56-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
16160008-1	2006	Divalent metal transporter 1 (DMT1) mediates apical iron uptake in duodenal enterocytes and iron transfer from the transferrin receptor endosomal cycle into the cytosol in erythroid cells.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	30-34
35211089-9	2021	Our study demonstrated a decreased hepcidin level in AG patients in comparison to CS what may have a potentially protective effect against anemia through an increased bioavailability of Fe.	Iron	186-188	hepcidin antimicrobial peptide	Homo sapiens	35-43
16160008-1	2006	Divalent metal transporter 1 (DMT1) mediates apical iron uptake in duodenal enterocytes and iron transfer from the transferrin receptor endosomal cycle into the cytosol in erythroid cells.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	0-28
35107212-4	2022	NRF2 and BACH1 inhibit and promote ferroptosis, respectively, by activating or suppressing the expression of genes in the major regulatory pathways of ferroptosis: intracellular labile iron metabolism, the GSH (glutathione) -GPX4 (glutathione peroxidase 4) pathway, and the FSP1 (ferroptosis suppressor protein 1)-CoQ (coenzyme Q) pathway.	Iron	185-189	glutathione peroxidase 4	Homo sapiens	225-229
16160008-1	2006	Divalent metal transporter 1 (DMT1) mediates apical iron uptake in duodenal enterocytes and iron transfer from the transferrin receptor endosomal cycle into the cytosol in erythroid cells.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	30-34
35107212-4	2022	NRF2 and BACH1 inhibit and promote ferroptosis, respectively, by activating or suppressing the expression of genes in the major regulatory pathways of ferroptosis: intracellular labile iron metabolism, the GSH (glutathione) -GPX4 (glutathione peroxidase 4) pathway, and the FSP1 (ferroptosis suppressor protein 1)-CoQ (coenzyme Q) pathway.	Iron	185-189	glutathione peroxidase 4	Homo sapiens	231-255
16160008-3	2006	We report the hematologic phenotype of a child, compound heterozygote for 2 DMT1 mutations, who was affected by severe anemia since birth and showed hepatic iron overload.	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	76-80
35018919-0	2022	Porous N-doped carbon with confined Fe-doped CoP grown on CNTs for superefficient oxygen evolution electrocatalysis.	Iron	36-38	caspase recruitment domain family member 16	Homo sapiens	45-48
16160008-8	2006	The early onset of iron overload indicates that, as in animal models, DMT1 is dispensable for liver iron uptake, whereas its deficiency in the gut is likely bypassed by the up-regulation of other pathways of iron use.	Iron	19-23	solute carrier family 11 member 2	Homo sapiens	70-74
17134988-10	2006	The inflammatory cells in the endomysium were reactive for CD68, cytosolic ferritin, and the DMT1 isoform(s) translated from messenger ribonucleic acids containing iron-responsive elements (DMT1+).	Iron	164-168	solute carrier family 11 member 2	Homo sapiens	93-97
35107514-4	2022	Iron and manganese ions were confirmed through nonradiative relaxation (tau) and characteristic diffusion (taubeta) times evaluation, whose values were found to be tauBRA = 5.40 ms, tauCUB = 4.60 ms, taubetaBRA = 387 mus and taubetaCUB = 305 mus.	Iron	0-4	microtubule associated protein tau	Homo sapiens	72-75
35161041-2	2022	Herein, DOX is loaded into iron-rich metal-organic framework/tannic acid (TA) nanocomplex to form a tumor-targeting and acid-activatable drug delivery system (MOF/TA-DOX, MTD).	Iron	27-31	metallothionein 1E	Homo sapiens	171-174
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	glutamate-cysteine ligase, modifier subunit	Mus musculus	246-250
35163229-3	2022	The most harmful complication of CDA II is the severe iron overload.	Iron	54-58	SEC23 homolog B, COPII coat complex component	Homo sapiens	33-39
35163229-4	2022	Within our case series (28 CDA II patients), approximately 36% of them exhibit severe iron overload despite mild degree of anemia and slightly increased levels of ERFE (the only erythroid regulator of hepcidin suppression).	Iron	86-90	SEC23 homolog B, COPII coat complex component	Homo sapiens	27-33
35163229-5	2022	Thus, we hypothesized a direct role of SEC23B loss-of-function in the pathomechanism of hepatic iron overload.	Iron	96-100	SEC23 homolog B, COPII coat complex component	Homo sapiens	39-45
35163229-10	2022	Our findings suggested that the pathogenic mechanism of iron overload in CDA II is associated to both ineffective erythropoiesis and to a specific involvement of SEC23B pathogenic variants at hepatic level.	Iron	56-60	SEC23 homolog B, COPII coat complex component	Homo sapiens	73-79
35163229-10	2022	Our findings suggested that the pathogenic mechanism of iron overload in CDA II is associated to both ineffective erythropoiesis and to a specific involvement of SEC23B pathogenic variants at hepatic level.	Iron	56-60	SEC23 homolog B, COPII coat complex component	Homo sapiens	162-168
35065677-1	2022	BACKGROUND: Human hepcidin, produced by hepatocytes, regulates intestinal iron absorption, iron recycling by macrophages, and iron release from hepatic storage.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	18-26
35065677-1	2022	BACKGROUND: Human hepcidin, produced by hepatocytes, regulates intestinal iron absorption, iron recycling by macrophages, and iron release from hepatic storage.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	18-26
35065677-1	2022	BACKGROUND: Human hepcidin, produced by hepatocytes, regulates intestinal iron absorption, iron recycling by macrophages, and iron release from hepatic storage.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	18-26
35065677-10	2022	CONCLUSION: The discovery of hepcidin and its role in iron metabolism could lead to novel therapies for hereditary hemochromatosis.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	29-37
35065677-13	2022	Laennec and Porcine can completely replace continuous venesection in patients with venesection and may improve other iron-overloading disorders caused by hepcidin deficiency.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	154-162
35007077-8	2022	The momentum distribution obtained from the velocity distributions of Fe, Fe(CO)4, and CO fragments further supported that Fe is the counter-product of the high-v CO fragment.	Iron	123-125	complement C4A (Rodgers blood group)	Homo sapiens	74-81
35163911-0	2022	Application of TOF-SIMS Method in the Study of Wetting the Iron (111) Surface with Promoter Oxides.	Iron	59-63	FEZ family zinc finger 2	Homo sapiens	15-18
35163911-2	2022	It was shown that efficient oxygen diffusion from metal oxides to the clean Fe(111) iron surface took place even at temperatures lower than 100  C. The effective wetting of the iron surface by potassium oxide is possible when the surface is covered with oxygen at temperatures above 250  C. In the TOF-SIMS spectra of the surface of iron wetted with potassium, an emission of secondary FeOK+ ions was observed that implies that potassium atoms are bound to the iron surface atoms through oxygen.	Iron	76-78	FEZ family zinc finger 2	Homo sapiens	298-301
35163911-2	2022	It was shown that efficient oxygen diffusion from metal oxides to the clean Fe(111) iron surface took place even at temperatures lower than 100  C. The effective wetting of the iron surface by potassium oxide is possible when the surface is covered with oxygen at temperatures above 250  C. In the TOF-SIMS spectra of the surface of iron wetted with potassium, an emission of secondary FeOK+ ions was observed that implies that potassium atoms are bound to the iron surface atoms through oxygen.	Iron	84-88	FEZ family zinc finger 2	Homo sapiens	298-301
35163911-2	2022	It was shown that efficient oxygen diffusion from metal oxides to the clean Fe(111) iron surface took place even at temperatures lower than 100  C. The effective wetting of the iron surface by potassium oxide is possible when the surface is covered with oxygen at temperatures above 250  C. In the TOF-SIMS spectra of the surface of iron wetted with potassium, an emission of secondary FeOK+ ions was observed that implies that potassium atoms are bound to the iron surface atoms through oxygen.	Iron	177-181	FEZ family zinc finger 2	Homo sapiens	298-301
35045308-2	2022	The transcription factor HIF2alpha, which regulates iron absorption in the duodenum, increases following these surgeries.	Iron	52-56	endothelial PAS domain protein 1	Homo sapiens	25-34
35045308-6	2022	These data demonstrate a role for increased duodenal HIF2alpha signaling in regulating crosstalk between iron-regulatory systems and other aspects of systemic physiology important for metabolic regulation.	Iron	105-109	endothelial PAS domain protein 1	Homo sapiens	53-62
35208164-2	2022	However, hepcidin, the iron regulatory peptide that inhibits iron absorption, unexpectedly upregulates ATP4 and increases gastric acidity.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	9-17
35208164-2	2022	However, hepcidin, the iron regulatory peptide that inhibits iron absorption, unexpectedly upregulates ATP4 and increases gastric acidity.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	9-17
35208164-9	2022	Under iron-rich diet, the protein expression of ATP4A was increased and serum, hepatic and gastric hepcidin were all induced.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	99-107
35052868-1	2022	Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron absorption and plasma iron concentration.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	33-41
35052868-1	2022	Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron absorption and plasma iron concentration.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	33-41
35052868-1	2022	Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron absorption and plasma iron concentration.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	33-41
35052868-2	2022	Hepcidin binds to the only known iron export protein, ferroportin (FPN), which regulates its expression.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
35052868-3	2022	The major factors that implicate hepcidin regulation include iron stores, hypoxia, inflammation, and erythropoiesis.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	33-41
35052868-4	2022	When erythropoietic activity is suppressed, hepcidin expression is hampered, leading to deficiency, thus causing an iron overload in iron-loading anemia, such as beta-thalassemia.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	44-52
35052868-4	2022	When erythropoietic activity is suppressed, hepcidin expression is hampered, leading to deficiency, thus causing an iron overload in iron-loading anemia, such as beta-thalassemia.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	44-52
35052868-7	2022	In contrast, iron overload is attributed to hepcidin deficiency and hyperabsorption of dietary iron in non-transfusion thalassemia.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	44-52
35038100-6	2022	PC1 comprises EC, TDS, As, Fe, TOC, and HCO3- with moderate loadings, which suggests microbially mediated degradation of organic matter (OM), helps in reductive dissolution of arsenic-bearing Fe-Mn oxyhydroxides.	Iron	27-29	proprotein convertase subtilisin/kexin type 1	Homo sapiens	0-3
35053120-6	2022	ENaC activity in cultured Xenopus 2F3 cells and mpkCCD cells was inhibited by iron, which could be reversed by iron chelation.	Iron	78-82	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	0-4
35053120-6	2022	ENaC activity in cultured Xenopus 2F3 cells and mpkCCD cells was inhibited by iron, which could be reversed by iron chelation.	Iron	111-115	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	0-4
35053120-7	2022	Thus, our novel findings implicate iron as a regulator of ENaC protein and its activity.	Iron	35-39	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	58-62
35052458-1	2022	BACKGROUND: Hemochromatosis is a genetic condition of iron overload caused by deficiency of hepcidin.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	92-100
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	261-265	glutathione peroxidase 4	Homo sapiens	134-158
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	261-265	glutathione peroxidase 4	Homo sapiens	159-163
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	261-265	glutathione peroxidase 4	Homo sapiens	255-259
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	336-340	glutathione peroxidase 4	Homo sapiens	134-158
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	336-340	glutathione peroxidase 4	Homo sapiens	159-163
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	396-400	glutathione peroxidase 4	Homo sapiens	134-158
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	396-400	glutathione peroxidase 4	Homo sapiens	159-163
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	409-413	glutathione peroxidase 4	Homo sapiens	134-158
35050181-3	2022	The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes.	Iron	409-413	glutathione peroxidase 4	Homo sapiens	159-163
35054862-6	2022	The duo, namely, Fe and Cu, following their inordinate exposure, are viable of permeating across the blood-brain barrier (BBB) and moving inside the brain, thereby culminating in the escalated OS (through a reactive oxygen species (ROS)-reliant pathway), alpha-synuclein aggregation within the LBs, and lipid peroxidation, which consequently results in the destruction of DArgic nerve cells and facilitates PD emanation.	Iron	17-19	synuclein alpha	Homo sapiens	255-270
35057424-5	2022	We developed a novel model of rat pups sepsis induced by bacterial translocation and observed the inhibition of this process by supplementation of various forms of lactoferrin: iron-depleted (apolactoferrin), iron-saturated (hololactoferrin) and manganese-saturated lactoferrin.	Iron	209-213	lactotransferrin	Rattus norvegicus	164-175
35008961-1	2022	Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein associated with neurodegenerative diseases.	Iron	49-53	ferritin mitochondrial	Homo sapiens	0-22
35008961-1	2022	Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein associated with neurodegenerative diseases.	Iron	49-53	ferritin mitochondrial	Homo sapiens	24-28
35125696-3	2022	One such protein is hepcidin which internalizes ferroportin (membrane iron transporter), thus inhibiting iron export from macrophages which is utilised by bacteria leading to disease severity.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	20-28
35125696-8	2022	Upon infection, regulation of iron absorption is disturbed via increased hepcidin levels leading to ferroportin internalization and thus inhibition of iron export from macrophages which may lead to favourable M.tb.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	73-81
35125696-8	2022	Upon infection, regulation of iron absorption is disturbed via increased hepcidin levels leading to ferroportin internalization and thus inhibition of iron export from macrophages which may lead to favourable M.tb.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	73-81
35253768-7	2022	RESULTS: HFD caused nonheme iron overload in the brains of APPswe/PS1dE9 (APP/PS1) mice.	Iron	28-32	presenilin 1	Mus musculus	78-81
35253768-11	2022	In addition, iron chelation effectively reduced synaptic impairment in hippocampus and neuronal degeneration in cortex in the HFD-fed APP/PS1 mice.	Iron	13-17	presenilin 1	Mus musculus	138-141
35253768-12	2022	Meanwhile, iron chelation decreased Abeta 1-40 and Abeta 1-42 level as well as neuroinflammation in HFD-fed APP/PS1 mice.	Iron	11-15	presenilin 1	Mus musculus	112-115
34710708-0	2022	Triad role of hepcidin, ferroportin, and Nrf2 in cardiac iron metabolism: From health to disease.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	14-22
34710708-5	2022	Iron availability to the heart is therefore tightly regulated by (i) the hepcidin/ferroportin axis, which controls dietary iron absorption, storage, and recycling, and (ii) iron regulatory proteins 1 and 2 (IRP1/2) via hypoxia inducible factor 1 (HIF1) pathway.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	73-81
34710708-5	2022	Iron availability to the heart is therefore tightly regulated by (i) the hepcidin/ferroportin axis, which controls dietary iron absorption, storage, and recycling, and (ii) iron regulatory proteins 1 and 2 (IRP1/2) via hypoxia inducible factor 1 (HIF1) pathway.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	73-81
34710708-9	2022	Consequently, it is possible that Nrf2/hepcidin/ferroportin might act as an epicenter connecting iron metabolism to redox alterations.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	39-47
35121990-3	2022	Here, we show that ENO1 suppresses iron regulatory protein 1 (IRP1) expression to regulate iron homeostasis and survival of hepatocellular carcinoma (HCC) cells.	Iron	91-95	enolase 1	Homo sapiens	19-23
35121990-4	2022	Mechanistically, we demonstrate that ENO1, as an RNA-binding protein, recruits CNOT6 to accelerate the messenger RNA decay of IRP1 in cancer cells, leading to inhibition of mitoferrin-1 (Mfrn1) expression and subsequent repression of mitochondrial iron-induced ferroptosis.	Iron	248-252	enolase 1	Homo sapiens	37-41
35121990-4	2022	Mechanistically, we demonstrate that ENO1, as an RNA-binding protein, recruits CNOT6 to accelerate the messenger RNA decay of IRP1 in cancer cells, leading to inhibition of mitoferrin-1 (Mfrn1) expression and subsequent repression of mitochondrial iron-induced ferroptosis.	Iron	248-252	RNA binding motif single stranded interacting protein 3	Homo sapiens	49-68
35124772-3	2021	Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1.	Iron	66-70	solute carrier family 40 member 1	Homo sapiens	0-12
35124772-3	2021	Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1.	Iron	66-70	solute carrier family 40 member 1	Homo sapiens	14-18
35124772-3	2021	Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1.	Iron	110-114	solute carrier family 40 member 1	Homo sapiens	0-12
17134988-10	2006	The inflammatory cells in the endomysium were reactive for CD68, cytosolic ferritin, and the DMT1 isoform(s) translated from messenger ribonucleic acids containing iron-responsive elements (DMT1+).	Iron	164-168	solute carrier family 11 member 2	Homo sapiens	190-194
17175894-2	2006	Reticulocyte hemoglobin content (RET-He) is considered to be an actual indicator reflecting functional iron availability for erythropoiesis.	Iron	103-107	ret proto-oncogene	Homo sapiens	33-36
16909922-0	2006	Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
16909922-2	2006	Hepcidin is the homeostatic regulator of intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores, but it is also markedly induced during infections and inflammation.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
16909922-2	2006	Hepcidin is the homeostatic regulator of intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores, but it is also markedly induced during infections and inflammation.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
16909922-2	2006	Hepcidin is the homeostatic regulator of intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores, but it is also markedly induced during infections and inflammation.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
16909922-3	2006	Under the influence of hepcidin, macrophages, hepatocytes, and enterocytes retain iron that would otherwise be released into plasma.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	23-31
16909922-4	2006	Hepcidin acts by inhibiting the efflux of iron through ferroportin, the sole known iron exporter that is expressed in the small intestine, and in hepatocytes and macrophages.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
16909922-4	2006	Hepcidin acts by inhibiting the efflux of iron through ferroportin, the sole known iron exporter that is expressed in the small intestine, and in hepatocytes and macrophages.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	0-8
16909922-5	2006	As befits an iron-regulatory hormone, hepcidin synthesis is increased by iron loading, and decreased by anemia and hypoxia.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	38-46
16909922-8	2006	The decrease in extracellular iron concentrations due to hepcidin probably limits iron availability to invading microorganisms, thus contributing to host defense.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	57-65
16909922-8	2006	The decrease in extracellular iron concentrations due to hepcidin probably limits iron availability to invading microorganisms, thus contributing to host defense.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	57-65
16325907-1	2006	Hepcidin, originally identified as a 25 amino acid peptide antibiotic produced in the liver, is a key regulator of iron balance and recycling in humans and mice.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	0-8
16546437-0	2006	Heat shock protein 27 downregulates the transferrin receptor 1-mediated iron uptake.	Iron	72-76	heat shock protein family B (small) member 1	Homo sapiens	0-21
16546437-1	2006	It has been reported that over-expression of human heat shock protein 27 (hsp27) in murine cells decreased the intracellular iron level [Arrigo, A. P., Virot, S., Chaufour, S., Firdaus, W., Kretz-Remy, C., &amp; Diaz-Latoud, C. (2005).	Iron	125-129	heat shock protein family B (small) member 1	Homo sapiens	51-72
16546437-1	2006	It has been reported that over-expression of human heat shock protein 27 (hsp27) in murine cells decreased the intracellular iron level [Arrigo, A. P., Virot, S., Chaufour, S., Firdaus, W., Kretz-Remy, C., &amp; Diaz-Latoud, C. (2005).	Iron	125-129	heat shock protein family B (small) member 1	Homo sapiens	74-79
16546437-2	2006	Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels.	Iron	114-118	heat shock protein family B (small) member 1	Homo sapiens	0-5
16546437-5	2006	In this study, the regulation of transferrin receptor 1 (TfR1)-mediated iron uptake by human hsp27 was investigated in CCL39 cells by overexpression of human hsp27 and its dominant-negative mutant (hsp27-3G).	Iron	72-76	heat shock protein family B (small) member 1	Homo sapiens	93-98
16546437-5	2006	In this study, the regulation of transferrin receptor 1 (TfR1)-mediated iron uptake by human hsp27 was investigated in CCL39 cells by overexpression of human hsp27 and its dominant-negative mutant (hsp27-3G).	Iron	72-76	heat shock protein family B (small) member 1	Homo sapiens	158-163
16546437-5	2006	In this study, the regulation of transferrin receptor 1 (TfR1)-mediated iron uptake by human hsp27 was investigated in CCL39 cells by overexpression of human hsp27 and its dominant-negative mutant (hsp27-3G).	Iron	72-76	heat shock protein family B (small) member 1	Homo sapiens	158-163
16546437-6	2006	The results showed that overexpression of hsp27 diminished intracellular labile iron pool, increased the binding activity of iron regulatory protein (IRP) to iron responsive element (IRE) and the cell surface-expressed TfR1s.	Iron	80-84	heat shock protein family B (small) member 1	Homo sapiens	42-47
16546437-6	2006	The results showed that overexpression of hsp27 diminished intracellular labile iron pool, increased the binding activity of iron regulatory protein (IRP) to iron responsive element (IRE) and the cell surface-expressed TfR1s.	Iron	125-129	heat shock protein family B (small) member 1	Homo sapiens	42-47
16546437-12	2006	Meanwhile, the possible involvement of ferroportin 1 in down-regulation of intracellular iron level by overexpression of hsp27 was checked.	Iron	89-93	solute carrier family 40 member 1	Homo sapiens	39-52
16546437-12	2006	Meanwhile, the possible involvement of ferroportin 1 in down-regulation of intracellular iron level by overexpression of hsp27 was checked.	Iron	89-93	heat shock protein family B (small) member 1	Homo sapiens	121-126
16546437-14	2006	Our findings indicate that hsp27 down-regulates TfR1-mediated iron uptake via stabilization of the cortical actin cytoskeleton rather than the classical IRP/IRE mode.	Iron	62-66	heat shock protein family B (small) member 1	Homo sapiens	27-32
16546437-15	2006	The study may also imply that hsp27 protects cells from oxidative stress by reducing cellular iron uptake.	Iron	94-98	heat shock protein family B (small) member 1	Homo sapiens	30-35
16342148-4	2006	The purpose of this study was to test the efficacy of a new MRI sequence GRASP (GRe Acquisition for Superparamagnetic Particles) to generate a positive signal in phantoms containing iron.	Iron	182-186	trafficking regulator and scaffold protein tamalin	Homo sapiens	73-78
16342148-4	2006	The purpose of this study was to test the efficacy of a new MRI sequence GRASP (GRe Acquisition for Superparamagnetic Particles) to generate a positive signal in phantoms containing iron.	Iron	182-186	trafficking regulator and scaffold protein tamalin	Homo sapiens	80-127
16342148-9	2006	The GRASP sequence generated positive signal enhancement in phantoms containing iron.	Iron	80-84	trafficking regulator and scaffold protein tamalin	Homo sapiens	4-9
16342148-14	2006	In conclusion, GRASP sequences may be used to generate positive signal enhancement in the presence of iron using MRI.	Iron	102-106	trafficking regulator and scaffold protein tamalin	Homo sapiens	15-20
16091957-1	2006	The H(+) -coupled divalent metal-ion transporter DMT1 serves as both the primary entry point for iron into the body (intestinal brush-border uptake) and the route by which transferrin-associated iron is mobilized from endosomes to cytosol in erythroid precursors and other cells.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	49-53
16091957-1	2006	The H(+) -coupled divalent metal-ion transporter DMT1 serves as both the primary entry point for iron into the body (intestinal brush-border uptake) and the route by which transferrin-associated iron is mobilized from endosomes to cytosol in erythroid precursors and other cells.	Iron	195-199	solute carrier family 11 member 2	Homo sapiens	49-53
16091957-2	2006	Elucidating the molecular mechanisms of DMT1 will therefore increase our understanding of iron metabolism and the etiology of iron overload disorders.	Iron	90-94	solute carrier family 11 member 2	Homo sapiens	40-44
16091957-2	2006	Elucidating the molecular mechanisms of DMT1 will therefore increase our understanding of iron metabolism and the etiology of iron overload disorders.	Iron	126-130	solute carrier family 11 member 2	Homo sapiens	40-44
16091957-12	2006	Since plasma membrane expression of DMT1 is upregulated in liver of hemochromatosis patients, this H(+) -uncoupled facilitative Fe(2+) transport via DMT1 can account for the uptake of nontransferrin-bound plasma iron characteristic of iron overload disorders.	Iron	212-216	solute carrier family 11 member 2	Homo sapiens	36-40
16091957-12	2006	Since plasma membrane expression of DMT1 is upregulated in liver of hemochromatosis patients, this H(+) -uncoupled facilitative Fe(2+) transport via DMT1 can account for the uptake of nontransferrin-bound plasma iron characteristic of iron overload disorders.	Iron	212-216	solute carrier family 11 member 2	Homo sapiens	149-153
16091957-12	2006	Since plasma membrane expression of DMT1 is upregulated in liver of hemochromatosis patients, this H(+) -uncoupled facilitative Fe(2+) transport via DMT1 can account for the uptake of nontransferrin-bound plasma iron characteristic of iron overload disorders.	Iron	235-239	solute carrier family 11 member 2	Homo sapiens	36-40
16091957-12	2006	Since plasma membrane expression of DMT1 is upregulated in liver of hemochromatosis patients, this H(+) -uncoupled facilitative Fe(2+) transport via DMT1 can account for the uptake of nontransferrin-bound plasma iron characteristic of iron overload disorders.	Iron	235-239	solute carrier family 11 member 2	Homo sapiens	149-153
17580549-3	2006	Hepcidin plays key role in iron homeostasis.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
17236285-4	2006	Very recently it was discovered a peptide produced by the liver, named hepcidin, that provides a good link between inflammation and metabolism of iron, rendering more understandable the interdependence of inflammation and anemia.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	71-79
16185653-0	2005	Distinctive iron requirement of tryptophan 5-monooxygenase: TPH1 requires dissociable ferrous iron.	Iron	12-16	tryptophan hydroxylase 1	Homo sapiens	60-64
16185653-0	2005	Distinctive iron requirement of tryptophan 5-monooxygenase: TPH1 requires dissociable ferrous iron.	Iron	86-98	tryptophan hydroxylase 1	Homo sapiens	60-64
16185653-2	2005	In this study, distinctive iron requirement of TPH1 was revealed through analysis of the enzyme"s inactivation and activation by DTT.	Iron	27-31	tryptophan hydroxylase 1	Homo sapiens	47-51
16186124-4	2005	Like other 2OG oxygenases, PAHX possesses a double-stranded beta-helix core, which supports three iron binding ligands (His(175), Asp(177), and His(264)); the 2-oxoacid group of 2OG binds to the Fe(II) in a bidentate manner.	Iron	98-102	phytanoyl-CoA 2-hydroxylase	Homo sapiens	27-31
16316238-1	2005	The rebinding kinetics of NO to the heme iron of myoglobin (Mb) is investigated as a function of temperature.	Iron	41-45	myoglobin	Homo sapiens	49-58
16123094-2	2005	Two isoforms, which differ by the presence (DMT1-IRE) or absence (DMT1-nonIRE) of an iron-responsive element (IRE) in their 3" untranslated region, are implicated in apical iron transport and endosomal iron transport respectively.	Iron	85-89	solute carrier family 11 member 2	Homo sapiens	66-70
16123094-2	2005	Two isoforms, which differ by the presence (DMT1-IRE) or absence (DMT1-nonIRE) of an iron-responsive element (IRE) in their 3" untranslated region, are implicated in apical iron transport and endosomal iron transport respectively.	Iron	173-177	solute carrier family 11 member 2	Homo sapiens	44-48
16123094-2	2005	Two isoforms, which differ by the presence (DMT1-IRE) or absence (DMT1-nonIRE) of an iron-responsive element (IRE) in their 3" untranslated region, are implicated in apical iron transport and endosomal iron transport respectively.	Iron	173-177	solute carrier family 11 member 2	Homo sapiens	66-70
16123094-2	2005	Two isoforms, which differ by the presence (DMT1-IRE) or absence (DMT1-nonIRE) of an iron-responsive element (IRE) in their 3" untranslated region, are implicated in apical iron transport and endosomal iron transport respectively.	Iron	173-177	solute carrier family 11 member 2	Homo sapiens	44-48
16123094-2	2005	Two isoforms, which differ by the presence (DMT1-IRE) or absence (DMT1-nonIRE) of an iron-responsive element (IRE) in their 3" untranslated region, are implicated in apical iron transport and endosomal iron transport respectively.	Iron	173-177	solute carrier family 11 member 2	Homo sapiens	66-70
16123094-10	2005	Predominant DMT1-IRE isoform expression in placenta suggests an iron-regulatory mechanism reminiscent of that in the adult duodenum.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	12-16
16246823-2	2005	We replaced Ser71 in Mc b5 with Leu, with the prediction that it would retard heme loss by diminishing polypeptide expansion accompanying rupture of the histidine to iron bonds.	Iron	166-170	cytochrome b5 type A	Homo sapiens	21-26
16030189-1	2005	The hepatic peptide hormone hepcidin is the central regulator of iron metabolism and mediator of anemia of inflammation.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	28-36
16030189-7	2005	Most importantly, this hepcidin assay clearly discriminates between relevant clinical iron disorders.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	23-31
16298746-7	2005	Increased expression of DMT-1 and IREG-1 was associated with iron accumulation and oxidative stress.	Iron	61-65	solute carrier family 11 member 2	Homo sapiens	24-29
16298746-7	2005	Increased expression of DMT-1 and IREG-1 was associated with iron accumulation and oxidative stress.	Iron	61-65	solute carrier family 40 member 1	Homo sapiens	34-40
16198622-2	2005	Hepcidin is thought to be a key regulator in iron metabolism and has been implicated in ACD.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
16308480-5	2005	While total RNA yield and abundance were not significantly altered, both iron and aluminum were found to induce HSP27, COX-2, betaAPP and DAXX gene expression.	Iron	73-77	heat shock protein family B (small) member 1	Homo sapiens	112-117
16208635-8	2005	Heme oxygenase-1 is a heme-degrading enzyme that opens the porphyrin ring, producing biliverdin, carbon monoxide, and the most dangerous product - free redox active iron.	Iron	165-169	heme oxygenase 1	Homo sapiens	0-16
16315135-5	2005	Hepcidin serves to decrease the export of iron from reticuloendothelial cells and absorptive enterocytes.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
16315136-2	2005	It is the major site of iron storage, it regulates iron traffic into and around the body through its production of the peptide hepcidin, and it is the site of synthesis of major proteins of iron metabolism such as transferrin and ceruloplasmin.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	127-135
16315136-2	2005	It is the major site of iron storage, it regulates iron traffic into and around the body through its production of the peptide hepcidin, and it is the site of synthesis of major proteins of iron metabolism such as transferrin and ceruloplasmin.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	127-135
16315136-3	2005	Most of the iron that enters the liver is derived from plasma transferrin under normal circumstances, and transferrin receptors 1 and 2 play important roles in this process.	Iron	12-16	transferrin receptor 2	Homo sapiens	106-135
16315136-6	2005	The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin.	Iron	31-35	solute carrier family 40 member 1	Homo sapiens	78-91
16315136-6	2005	The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin.	Iron	31-35	ceruloplasmin	Homo sapiens	122-135
16315136-6	2005	The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin.	Iron	64-68	solute carrier family 40 member 1	Homo sapiens	78-91
16315136-6	2005	The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin.	Iron	64-68	ceruloplasmin	Homo sapiens	122-135
16315136-7	2005	Hepcidin can regulate this iron release through its interaction with ferroportin.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	0-8
16081413-1	2005	We previously noted strong induction of genes related to intestinal copper homeostasis (Menkes Copper ATPase (Atp7a) and metallothionein) in the duodenal epithelium of iron-deficient rats across several stages of postnatal development (Collins, J. F., Franck, C. A., Kowdley, K. V., and Ghishan, F. K. (2005) Am.	Iron	168-172	ATPase copper transporting alpha	Rattus norvegicus	110-115
16081413-10	2005	We further demonstrate that ATP7A protein levels are dramatically increased in brush-border and basolateral membrane vesicles isolated from iron-deficient rats.	Iron	140-144	ATPase copper transporting alpha	Rattus norvegicus	28-33
16081413-12	2005	We conclude that ATP7A is involved in copper loading observed during iron deficiency and that increased intestinal copper transport is of physiological relevance, as copper plays important roles in overall body iron homeostasis.	Iron	69-73	ATPase copper transporting alpha	Rattus norvegicus	17-22
16853444-0	2005	Single-atom test of all-atom empirical potentials: Fe in myoglobin.	Iron	51-53	myoglobin	Homo sapiens	57-66
16853444-3	2005	A Green function technique is developed to calculate the iron vibrational spectrum of deoxy-myoglobin by coupling the independently calculated heme and globin normal modes; nonbonded interactions between the heme molecule and the protein are essential for a good fit to the measurements.	Iron	57-61	myoglobin	Homo sapiens	92-101
16160078-3	2005	The identification of key molecules, including the iron regulatory peptide hepcidin, and the analysis of how they are regulated and interact have led to the development of an integrated model for the control of iron absorption by body iron requirements.	Iron	211-215	hepcidin antimicrobial peptide	Homo sapiens	75-83
16160078-3	2005	The identification of key molecules, including the iron regulatory peptide hepcidin, and the analysis of how they are regulated and interact have led to the development of an integrated model for the control of iron absorption by body iron requirements.	Iron	211-215	hepcidin antimicrobial peptide	Homo sapiens	75-83
15975770-3	2005	The solution behaviour and the iron binding properties of the two Tf variants were studied by UV-visible spectrophotometry and by circular dichroism.	Iron	31-35	coagulation factor III, tissue factor	Homo sapiens	66-68
15975770-5	2005	The local conformation of the two iron binding sites is conserved in the two Tf variants as evidenced by the visible absorption and CD spectra.	Iron	34-38	coagulation factor III, tissue factor	Homo sapiens	77-79
16143096-4	2005	Their identification of heme carrier protein 1 (HCP1) provides a major missing piece in our understanding of iron uptake and mammalian nutrition.	Iron	109-113	solute carrier family 46 member 1	Homo sapiens	24-46
16143096-4	2005	Their identification of heme carrier protein 1 (HCP1) provides a major missing piece in our understanding of iron uptake and mammalian nutrition.	Iron	109-113	solute carrier family 46 member 1	Homo sapiens	48-52
16143108-6	2005	HCP 1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency.	Iron	18-22	solute carrier family 46 member 1	Homo sapiens	0-5
15901240-7	2005	However, by 24 h, both iron import and iron export were significantly inhibited, coinciding with an induction of ferritin heavy chain (P&lt;0.05) and a decrease in DMT-1 and IREG-1 to baseline levels.	Iron	39-43	ferritin heavy chain 1	Homo sapiens	113-133
15886319-7	2005	These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system.	Iron	175-179	hepcidin antimicrobial peptide	Homo sapiens	63-71
16009582-0	2005	Recombinant human hepcidin expressed in Escherichia coli isolates as an iron containing protein.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	18-26
16009582-1	2005	Hepcidin is a small peptide that acts as a regulator of systemic iron homeostasis.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	0-8
16009582-3	2005	The fusion ferritin-hepcidin produced molecules retaining most of ferritin structural and functional properties, including ferroxidase and iron incorporation activities.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	20-28
16009582-4	2005	However, it showed spectroscopic properties compatible with the presence of iron-sulfur complexes on the hepcidin moiety, which was buried into protein cavity.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	105-113
16009582-8	2005	We concluded that the cysteine-rich hepcidin acts as an iron-sequestering molecule during expression in E. coli.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	36-44
16023393-0	2005	Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload.	Iron	141-145	solute carrier family 11 member 2	Homo sapiens	41-45
16023393-0	2005	Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload.	Iron	141-145	solute carrier family 11 member 2	Homo sapiens	46-52
16023393-0	2005	Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload.	Iron	141-145	solute carrier family 11 member 2	Homo sapiens	53-60
16023393-1	2005	DMT1 (Nramp2, Slc11a2) mediates iron uptake at the intestinal brush border and across the membrane of acidified endosomes.	Iron	32-36	solute carrier family 11 member 2	Homo sapiens	0-4
16023393-1	2005	DMT1 (Nramp2, Slc11a2) mediates iron uptake at the intestinal brush border and across the membrane of acidified endosomes.	Iron	32-36	solute carrier family 11 member 2	Homo sapiens	6-12
16023393-1	2005	DMT1 (Nramp2, Slc11a2) mediates iron uptake at the intestinal brush border and across the membrane of acidified endosomes.	Iron	32-36	solute carrier family 11 member 2	Homo sapiens	14-21
15963385-9	2005	Serum hepcidin concentration increased dramatically in all three subjects after only the first 120 mg dose of iron, and remained elevated even 9 days after cessation of the iron intervention.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	6-14
15963385-9	2005	Serum hepcidin concentration increased dramatically in all three subjects after only the first 120 mg dose of iron, and remained elevated even 9 days after cessation of the iron intervention.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	6-14
16085548-1	2005	In the last few years, the field of iron metabolism has exploded with the discovery of many new proteins including ferroportin, hephaestin, hepcidin, duodenal cytochrome b and the topic of this review, divalent metal ion transporter 1 (DMT1).	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	140-148
16085548-1	2005	In the last few years, the field of iron metabolism has exploded with the discovery of many new proteins including ferroportin, hephaestin, hepcidin, duodenal cytochrome b and the topic of this review, divalent metal ion transporter 1 (DMT1).	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	202-234
16085548-1	2005	In the last few years, the field of iron metabolism has exploded with the discovery of many new proteins including ferroportin, hephaestin, hepcidin, duodenal cytochrome b and the topic of this review, divalent metal ion transporter 1 (DMT1).	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	236-240
16085548-2	2005	DMT1 functions in transport of ferrous iron, and some, but not all divalent metal ions across the plasma membrane and/or out of the endosomal compartment.	Iron	39-43	solute carrier family 11 member 2	Homo sapiens	0-4
16085548-4	2005	Rodents with defects in iron absorption and utilization were identified long before it was determined that the defect was due to a single nucleotide mutation in DMT1.	Iron	24-28	solute carrier family 11 member 2	Homo sapiens	161-165
16085548-5	2005	Study of these animals reveals that transport of iron and other divalent metal ions by DMT1 is pH dependent, but the exact manner in which pH exerts its effect is unknown.	Iron	49-53	solute carrier family 11 member 2	Homo sapiens	87-91
16085548-9	2005	At least one signal for DMT1 expression appears to be intracellular iron status, however, other, as yet undefined signals may also contribute to DMT1 expression.	Iron	68-72	solute carrier family 11 member 2	Homo sapiens	24-28
16085548-10	2005	Interestingly, DMT1 function may differ subtly between humans and other animals; the spontaneous DMT1 mutation found in mice and rats appears to limit iron uptake in the intestine and iron utilization in red cell precursors, whereas the only known human mutation has its primary effect on iron utilization by erythroid cells.	Iron	151-155	solute carrier family 11 member 2	Homo sapiens	15-19
16085548-10	2005	Interestingly, DMT1 function may differ subtly between humans and other animals; the spontaneous DMT1 mutation found in mice and rats appears to limit iron uptake in the intestine and iron utilization in red cell precursors, whereas the only known human mutation has its primary effect on iron utilization by erythroid cells.	Iron	151-155	solute carrier family 11 member 2	Homo sapiens	97-101
16085548-10	2005	Interestingly, DMT1 function may differ subtly between humans and other animals; the spontaneous DMT1 mutation found in mice and rats appears to limit iron uptake in the intestine and iron utilization in red cell precursors, whereas the only known human mutation has its primary effect on iron utilization by erythroid cells.	Iron	184-188	solute carrier family 11 member 2	Homo sapiens	15-19
16085548-10	2005	Interestingly, DMT1 function may differ subtly between humans and other animals; the spontaneous DMT1 mutation found in mice and rats appears to limit iron uptake in the intestine and iron utilization in red cell precursors, whereas the only known human mutation has its primary effect on iron utilization by erythroid cells.	Iron	184-188	solute carrier family 11 member 2	Homo sapiens	97-101
16085548-10	2005	Interestingly, DMT1 function may differ subtly between humans and other animals; the spontaneous DMT1 mutation found in mice and rats appears to limit iron uptake in the intestine and iron utilization in red cell precursors, whereas the only known human mutation has its primary effect on iron utilization by erythroid cells.	Iron	184-188	solute carrier family 11 member 2	Homo sapiens	15-19
16085548-10	2005	Interestingly, DMT1 function may differ subtly between humans and other animals; the spontaneous DMT1 mutation found in mice and rats appears to limit iron uptake in the intestine and iron utilization in red cell precursors, whereas the only known human mutation has its primary effect on iron utilization by erythroid cells.	Iron	184-188	solute carrier family 11 member 2	Homo sapiens	97-101
16085548-11	2005	The importance of DMT1 function at the level of the whole organism and the individual cell and mechanisms of its regulation on a molecular scale are only beginning to be understood; an appreciation of these process will lead to an understanding of the role of iron in various cellular processes and improved treatments for both anemia and iron-overload.	Iron	260-264	solute carrier family 11 member 2	Homo sapiens	18-22
15797999-0	2005	Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
15797999-1	2005	Hepcidin, a key regulator of iron metabolism, is synthesized by the liver.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
15797999-2	2005	Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
15797999-2	2005	Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
15797999-5	2005	Moreover, we found in humans that hepcidin levels correlated with hepatic iron stores and hemoglobin levels and may also be affected by hepatic dysfunction.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	34-42
16081371-2	2005	Recent advances have indicated that the liver-derived peptide hepcidin plays a central role in this process by repressing iron release from intestinal enterocytes, macrophages and other body cells.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	62-70
16081371-3	2005	When iron requirements are increased, hepcidin levels decline and more iron enters the plasma.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	38-46
16081371-4	2005	It has been proposed that the level of circulating diferric transferrin, which reflects tissue iron levels, acts as a signal to alter hepcidin expression.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	134-142
16081371-6	2005	Patients carrying mutations in these molecules or in hepcidin itself develop systemic iron loading (or hemochromatosis) due to their inability to down regulate iron absorption.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	53-61
16081371-6	2005	Patients carrying mutations in these molecules or in hepcidin itself develop systemic iron loading (or hemochromatosis) due to their inability to down regulate iron absorption.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	53-61
16081371-7	2005	Hepcidin is also responsible for the decreased plasma iron or hypoferremia that accompanies inflammation and various chronic diseases as its expression is stimulated by pro-inflammatory cytokines such as interleukin 6.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
16081371-8	2005	The mechanisms underlying the regulation of hepcidin expression and how it acts on cells to control iron release are key areas of ongoing research.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	44-52
15875150-0	2005	Hemojuvelin: a supposed role in iron metabolism one year after its discovery.	Iron	32-36	hemojuvelin BMP co-receptor	Homo sapiens	0-11
15875150-1	2005	The discovery of hemojuvelin and its association with juvenile hemochromatosis are important not only for the diagnostics of this rare severe disease but also for the understanding of the complex mechanism of iron metabolism regulation.	Iron	209-213	hemojuvelin BMP co-receptor	Homo sapiens	17-28
15875150-5	2005	Hepcidin, generally accepted as a hormone targeting enterocytes and macrophages, decreases iron absorption from the intestinal lumen and iron release from phagocytes.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
15875150-5	2005	Hepcidin, generally accepted as a hormone targeting enterocytes and macrophages, decreases iron absorption from the intestinal lumen and iron release from phagocytes.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	0-8
15956209-1	2005	Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1, and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation.	Iron	17-21	solute carrier family 40 member 1	Homo sapiens	50-55
15956209-1	2005	Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1, and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation.	Iron	17-21	solute carrier family 40 member 1	Homo sapiens	57-64
15956209-1	2005	Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1, and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation.	Iron	17-21	solute carrier family 40 member 1	Homo sapiens	70-74
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Iron	129-133	ceruloplasmin	Mus musculus	263-276
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Iron	190-194	ceruloplasmin	Mus musculus	263-276
15817488-10	2005	Iron-induced internalization and degradation of Fet3p-Ftr1p occurs in a mutant strain of the E3 ubiquitin ligase RSP5 (rsp5-1), suggesting that Rsp5p is not required.	Iron	0-4	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	113-117
15817488-10	2005	Iron-induced internalization and degradation of Fet3p-Ftr1p occurs in a mutant strain of the E3 ubiquitin ligase RSP5 (rsp5-1), suggesting that Rsp5p is not required.	Iron	0-4	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	119-125
15817488-10	2005	Iron-induced internalization and degradation of Fet3p-Ftr1p occurs in a mutant strain of the E3 ubiquitin ligase RSP5 (rsp5-1), suggesting that Rsp5p is not required.	Iron	0-4	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	144-149
15929194-3	2005	RESULTS: Whereas in hereditary hemochromatosis patients without CD, DMT1 expression was up-regulated leading to excessive uptake of iron, we identified a significant reduction in protein and mRNA expression of DMT1 as a compensatory mechanism in this patient with HH and CD.	Iron	132-136	solute carrier family 11 member 2	Homo sapiens	68-72
15931225-8	2005	The observed structural changes, which impair the chemical reactivity of haem iron, explain how AHSP stabilizes alphaHb and prevents its damaging effects in cells.	Iron	78-82	alpha hemoglobin stabilizing protein	Homo sapiens	96-100
15737883-0	2005	Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
15737883-0	2005	Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
15737883-3	2005	Hepcidin acts by inhibiting the efflux of iron through ferroportin, the sole known iron exporter of enterocytes, macrophages and hepatocytes.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
15845359-1	2005	Ovotransferrin and lactoferrin are iron-binding proteins with antiviral and antibacterial activities related to natural immunity, showing marked sequence and structural homologies.	Iron	35-39	lactotransferrin	Bos taurus	19-30
15671438-0	2005	Hepcidin in iron overload disorders.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	0-8
15671438-1	2005	Hepcidin is the principal regulator of iron absorption in humans.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
15671438-5	2005	We measured urinary hepcidin in patients with other genetic causes of iron overload.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	20-28
15671438-8	2005	These findings extend the spectrum of iron disorders with hepcidin deficiency and underscore the critical importance of the hepcidin-ferroportin interaction in iron homeostasis.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	58-66
15823423-6	2005	Blocking HIF-1alpha reduces DFO protection suggesting that DFO protects through iron chelation and HIF-1alpha induction.	Iron	80-84	hypoxia inducible factor 1, alpha subunit	Mus musculus	9-19
15869597-2	2005	The present study explores the effects of intracellular iron on the expression of PAI-1 and associated cell-surface plasmin activity in human lung fibroblasts; and reports the presence of a novel iron-responsive protein.	Iron	56-60	serpin family E member 1	Homo sapiens	82-87
15869597-2	2005	The present study explores the effects of intracellular iron on the expression of PAI-1 and associated cell-surface plasmin activity in human lung fibroblasts; and reports the presence of a novel iron-responsive protein.	Iron	196-200	serpin family E member 1	Homo sapiens	82-87
15869597-6	2005	Experiments with transcription and translation inhibitors on TIG 3-20 cells demonstrated that intracellular iron modulated PAI-1 expression at the post-transcriptional level with the requirement of de-novo protein synthesis.	Iron	108-112	serpin family E member 1	Homo sapiens	123-128
15753101-7	2005	A direct growth comparison of yeast cells transformed with AtYSL2 in two different yeast expression vectors showed that transformation with empty pFL61 repressed growth even under non-limiting Fe supply.	Iron	193-195	YELLOW STRIPE like 2	Arabidopsis thaliana	59-65
15888686-5	2005	Here, we describe an additional putative component of the plastid Fe-S cluster assembly machinery in Arabidopsis: CpIscA, which has homology to bacterial IscA and SufA proteins that have a scaffold function during Fe-S cluster formation.	Iron	66-70	chloroplast-localized ISCA-like protein	Arabidopsis thaliana	114-120
15888686-5	2005	Here, we describe an additional putative component of the plastid Fe-S cluster assembly machinery in Arabidopsis: CpIscA, which has homology to bacterial IscA and SufA proteins that have a scaffold function during Fe-S cluster formation.	Iron	214-218	chloroplast-localized ISCA-like protein	Arabidopsis thaliana	114-120
15888686-10	2005	During incubation with CpNifS in a reconstitution mix, CpIscA was shown to acquire a transient Fe-S cluster.	Iron	95-99	chloroplast-localized ISCA-like protein	Arabidopsis thaliana	55-61
15888686-11	2005	The Fe-S cluster could subsequently be transferred by CpIscA to apo-ferredoxin.	Iron	4-8	chloroplast-localized ISCA-like protein	Arabidopsis thaliana	54-60
15888686-12	2005	We propose that the CpIscA protein serves as a scaffold in chloroplast Fe-S cluster assembly.	Iron	71-75	chloroplast-localized ISCA-like protein	Arabidopsis thaliana	20-26
15893030-4	2005	Ferroportin, TFR2, hemojuvelin and hepcidin mutations also cause iron overload.	Iron	65-69	transferrin receptor 2	Homo sapiens	13-17
15893030-4	2005	Ferroportin, TFR2, hemojuvelin and hepcidin mutations also cause iron overload.	Iron	65-69	hemojuvelin BMP co-receptor	Homo sapiens	19-30
15893030-4	2005	Ferroportin, TFR2, hemojuvelin and hepcidin mutations also cause iron overload.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	35-43
15897636-3	2005	It was located in the noncoding region of the ferroportin 1; nucleotide 117 adenine was changed to guanine, 7 nucleotides downstream the iron responsive element (IRE) region.	Iron	137-141	solute carrier family 40 member 1	Homo sapiens	46-59
15795591-1	2005	OBJECTIVES: To evaluate fecal elastase 1 (FE) levels in young children with cystic fibrosis and pancreatic insufficiency and to explore the relationship between FE and growth, nutrition, pulmonary status and fat absorption over a 24-month period.	Iron	42-44	chymotrypsin like elastase 3B	Homo sapiens	24-40
15792797-1	2005	A number of regulatory factors including dietary iron levels can dramatically alter the expression of the intestinal iron transporter DMT1.	Iron	49-53	solute carrier family 11 member 2	Homo sapiens	134-138
15792797-2	2005	Here we show that Caco-2 cells exposed to iron for 4h exhibited a significant decrease in plasma membrane DMT1 protein, though total cellular DMT1 levels were unaltered.	Iron	42-46	solute carrier family 11 member 2	Homo sapiens	106-110
15792797-2	2005	Here we show that Caco-2 cells exposed to iron for 4h exhibited a significant decrease in plasma membrane DMT1 protein, though total cellular DMT1 levels were unaltered.	Iron	42-46	solute carrier family 11 member 2	Homo sapiens	142-146
15792797-3	2005	Following biotinylation of cell surface proteins, there was a significant increase in intracellular biotin-labelled DMT1 in iron-exposed cells.	Iron	124-128	solute carrier family 11 member 2	Homo sapiens	116-120
15792797-4	2005	Furthermore, iron-treatment increased levels of DMT1 co-localised with LAMP1, suggesting that the initial response of intestinal epithelial cells to iron involves internalisation and targeting of DMT1 transporter protein towards a late endosomal/lysosomal compartment.	Iron	13-17	solute carrier family 11 member 2	Homo sapiens	48-52
15792797-4	2005	Furthermore, iron-treatment increased levels of DMT1 co-localised with LAMP1, suggesting that the initial response of intestinal epithelial cells to iron involves internalisation and targeting of DMT1 transporter protein towards a late endosomal/lysosomal compartment.	Iron	13-17	solute carrier family 11 member 2	Homo sapiens	196-200
15792797-4	2005	Furthermore, iron-treatment increased levels of DMT1 co-localised with LAMP1, suggesting that the initial response of intestinal epithelial cells to iron involves internalisation and targeting of DMT1 transporter protein towards a late endosomal/lysosomal compartment.	Iron	149-153	solute carrier family 11 member 2	Homo sapiens	48-52
15528311-5	2005	For instance, the disease X-linked sideroblastic anemia with ataxia (XLSA/A) is due to a mutation in the ATP-binding cassette protein B7 (ABCB7) transporter that is thought to transfer [Fe-S] clusters from the mitochondrion to the cytoplasm.	Iron	186-190	ATP binding cassette subfamily B member 7	Homo sapiens	105-136
2556968-14	1989	Since the cytosol normally maintains a highly oxidized NAD+/NADH redox ratio, it is interesting to speculate that increased availability of NADH from the oxidation of ethanol may support microsomal reduction of iron complexes, with the subsequent generation of reactive oxygen intermediates.	Iron	211-215	2,4-dienoyl-CoA reductase 1	Homo sapiens	140-144
2601714-1	1989	Transferrin is an iron-binding protein that is expressed as a major product in liver and secreted into the plasma.	Iron	18-22	transferrin	Mus musculus	0-11
15528311-5	2005	For instance, the disease X-linked sideroblastic anemia with ataxia (XLSA/A) is due to a mutation in the ATP-binding cassette protein B7 (ABCB7) transporter that is thought to transfer [Fe-S] clusters from the mitochondrion to the cytoplasm.	Iron	186-190	ATP binding cassette subfamily B member 7	Homo sapiens	138-143
16054062-0	2005	The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	30-37
2508514-4	1989	The increase in SAA concentration coincided with decreasing serum Zn and Fe concentrations; however, with decreasing serum Zn and Fe concentrations; however, Zn and Fe concentrations appeared to be restored when SAA concentration was still maximal.	Iron	73-75	serum amyloid A protein	Bos taurus	16-19
2508514-4	1989	The increase in SAA concentration coincided with decreasing serum Zn and Fe concentrations; however, with decreasing serum Zn and Fe concentrations; however, Zn and Fe concentrations appeared to be restored when SAA concentration was still maximal.	Iron	130-132	serum amyloid A protein	Bos taurus	16-19
2508514-4	1989	The increase in SAA concentration coincided with decreasing serum Zn and Fe concentrations; however, with decreasing serum Zn and Fe concentrations; however, Zn and Fe concentrations appeared to be restored when SAA concentration was still maximal.	Iron	130-132	serum amyloid A protein	Bos taurus	16-19
16054062-0	2005	The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.	Iron	55-59	solute carrier family 40 member 1	Homo sapiens	30-37
16054062-1	2005	Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release.	Iron	28-32	solute carrier family 40 member 1	Homo sapiens	13-20
2551301-5	1989	The third one is a low-spin iron-(III)-complex, possibly the methemoglobin-hydroxylamine adduct.	Iron	28-32	hemoglobin subunit gamma 2	Homo sapiens	61-74
16054062-1	2005	Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	13-20
16054062-3	2005	If ferroportin is the major cellular iron exporter, ineffective hepcidin function could explain manifestations of human hemochromatosis disorders.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	64-72
15854837-4	2005	Semi-quantitative reverse transcriptase (RT)-PCR and quantitative real-time RT-PCR revealed in Fe-deficient roots an enhanced accumulation of CsHA1 gene transcripts, which were hardly detectable in leaves.	Iron	95-97	plasma membrane ATPase 4	Cucumis sativus	142-147
2569464-1	1989	The synthesis of ferritin is regulated at the translation level in coordination with iron availability.	Iron	85-89	Fer2	Triticum aestivum	17-25
2569464-2	1989	Under conditions of low iron, translation of ferritin mRNA is repressed and the majority of ferritin mRNA is non-polysomal.	Iron	24-28	Fer2	Triticum aestivum	45-53
2569464-2	1989	Under conditions of low iron, translation of ferritin mRNA is repressed and the majority of ferritin mRNA is non-polysomal.	Iron	24-28	Fer2	Triticum aestivum	92-100
2569464-3	1989	Upon an increase in iron, translation of ferritin mRNA is derepressed resulting in as much as a 50-100-fold increase in the rate of ferritin synthesis.	Iron	20-24	Fer2	Triticum aestivum	41-49
2569464-3	1989	Upon an increase in iron, translation of ferritin mRNA is derepressed resulting in as much as a 50-100-fold increase in the rate of ferritin synthesis.	Iron	20-24	Fer2	Triticum aestivum	132-140
2569464-8	1989	In addition, it binds specifically to sequences contained within the first 92 nucleotides of ferritin mRNA, most likely the iron responsive element.	Iron	124-128	Fer2	Triticum aestivum	93-101
15854837-5	2005	Supply of iron to deficient plants caused a decrease in the transcript level of CsHA1.	Iron	10-14	plasma membrane ATPase 4	Cucumis sativus	80-85
15486069-1	2005	The hepatic peptide hepcidin is the key regulator of iron metabolism in mammals.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	20-28
2669970-7	1989	It is concluded that ferritin L-chain lacks the ferroxidase site present in the H-chain and that the two chains may have specialized functions in intracellular iron metabolism.	Iron	160-164	ferritin light chain	Homo sapiens	21-37
15486069-4	2005	Patients with C282Y HFE hemochromatosis also have inappropriately low hepcidin levels for the degree of iron loading.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	70-78
15486069-9	2005	Our data indicate that TFR2 is a modulator of hepcidin production in response to iron.	Iron	81-85	transferrin receptor 2	Homo sapiens	23-27
15486069-9	2005	Our data indicate that TFR2 is a modulator of hepcidin production in response to iron.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	46-54
2721585-1	1989	The relation of the growth-stimulating capacity of transferrin to its iron-transporting function was investigated in mouse hybridoma PLV-01 cells cultivated in a chemically defined medium.	Iron	70-74	transferrin	Mus musculus	51-62
15667273-5	2005	We also show that Nar1p is required for Fe-S cluster assembly on the P-loop NTPase Nbp35p, another newly identified component of the cytosolic Fe-S protein assembly machinery.	Iron	40-44	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	83-89
15667273-5	2005	We also show that Nar1p is required for Fe-S cluster assembly on the P-loop NTPase Nbp35p, another newly identified component of the cytosolic Fe-S protein assembly machinery.	Iron	143-147	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	83-89
2548577-0	1989	Endonuclease III is an iron-sulfur protein.	Iron	23-27	endonuclease III	Escherichia coli	0-16
15459009-0	2005	Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload.	Iron	83-87	solute carrier family 11 member 2	Homo sapiens	38-42
2548577-1	1989	Elemental analyses, Mossbauer, and EPR data are reported to show that endonuclease III of Escherichia coli is an iron-sulfur protein.	Iron	113-117	endonuclease III	Escherichia coli	70-86
2473026-1	1989	We report the localization of the gene for the human type 5, tartrate-resistant, iron-containing acid phosphatase isoenzyme (HGM designation ACP5) to chromosome 15 (15q22-q26) using the technique of in situ hybridization to metaphase chromosomes.	Iron	81-85	acid phosphatase 5, tartrate resistant	Homo sapiens	141-145
15459009-1	2005	Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport.	Iron	84-88	solute carrier family 11 member 2	Homo sapiens	0-28
15459009-1	2005	Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport.	Iron	84-88	solute carrier family 11 member 2	Homo sapiens	30-34
15459009-1	2005	Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport.	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	0-28
2539041-3	1989	The removal of a 4000-Da peptide explains the structural changes in the cytochrome c-552 molecule that resulted in the appearance of both cytochrome c peroxidase activity (with optimum activity at pH 8.6) and a high-spin heme iron.	Iron	226-230	cytochrome c3 family protein	Pseudomonas stutzeri	72-84
15459009-1	2005	Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport.	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	30-34
2501113-2	1989	NADPH-dependent iron and drug redox cycling, as well as lipid peroxidation process were investigated in microsomes isolated from human term placenta.	Iron	16-20	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
2501113-10	1989	Drastic peroxidative conditions involving superoxide and prolonged incubation in the presence of iron were found to destroy flavin nucleotides, inhibit NADPH:cytochrome P-450 reductase and inhibit propagation step of lipid peroxidation.	Iron	97-101	2,4-dienoyl-CoA reductase 1	Homo sapiens	152-157
15459009-4	2005	We report here the first human mutation of DMT1 identified in a female with severe hypochromic microcytic anemia and iron overload.	Iron	117-121	solute carrier family 11 member 2	Homo sapiens	43-47
2501113-12	1989	Reactive oxo-complex formed between iron and superoxide is proposed as an ultimate species for the initiation of lipid peroxidation in microsomes from human term placenta as well as for the destruction of flavin nucleotides and inhibition of NADPH:cytochrome P-450 reductase as well as for impairment of promotion of lipid peroxidation under drastic peroxidative conditions.	Iron	36-40	2,4-dienoyl-CoA reductase 1	Homo sapiens	242-247
15685557-1	2005	BACKGROUND AND AIMS: Juvenile hemochromatosis is a severe form of hereditary iron overload that has thus far been linked to pathogenic mutations of the gene coding for hemojuvelin (HJV), on chromosome 1, or, more rarely, that coding for hepcidin ( HAMP ), on chromosome 19.	Iron	77-81	hemojuvelin BMP co-receptor	Homo sapiens	168-179
15623549-3	2005	On the contrary, the fourth one, HLA-H, named HFE after it was found to be mutated in patients suffering from inherited hemochromatosis, has been shown to be involved only in the regulation of iron uptake.	Iron	193-197	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	33-38
3241959-3	1988	Iron concentration in the hair increased markedly after exposure to wet soil, and increased slightly after exposure to hot water from the boiler.	Iron	0-4	alcohol dehydrogenase iron containing 1	Homo sapiens	119-122
15684344-3	2005	Since the iron-regulatory and antimicrobial peptide hormone hepcidin was originally isolated from human urine we have investigated the expression as well as the zonal and cellular localization of hepcidin in the mammalian kidney and developed an ELISA assay to analyze hepcidin concentrations in serum and urine.	Iron	10-14	hepcidin antimicrobial peptide	Homo sapiens	60-68
2843373-5	1988	Besides changing the red shift spectrum of reduced cytochrome b566 and the EPR spectrum of the Rieske iron-sulfur cluster, the side chain alterations diminish the binding affinity and the extent of the midpoint potential shift of the iron-sulfur protein.	Iron	234-238	cytochrome b	Bos taurus	51-63
15684344-13	2005	Localization of hepcidin in the kidney implicates an iron-regulatory role of this peptide hormone in the renal tubular system, possibly in connection with the iron transporter divalent metal transporter-1.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	16-24
15895823-0	2005	Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice.	Iron	32-36	amyloid beta (A4) precursor protein	Mus musculus	40-45
3402348-1	1988	Gossypol-acetic acid (GAA) has been shown to be a powerful chelator of iron.	Iron	71-75	alpha glucosidase	Rattus norvegicus	22-25
3402348-4	1988	Iron [59Fe] incorporation was enhanced in the spleens, livers, bone marrow, and blood of the GAA-treated rats, and increased as the time post-[59Fe] injection increased.	Iron	0-4	alpha glucosidase	Rattus norvegicus	93-96
15895823-1	2005	This study confirms the presence of iron, co-localized with Abeta plaques, in PS/APP mouse brain, using Perls" stain for Fe3+ supplemented by 3,3"-diaminobenzidine (DAB) and Abeta immunohistochemistry in histological brains sections fixed with formalin or methacarn.	Iron	36-40	amyloid beta (A4) precursor protein	Mus musculus	60-65
15895823-1	2005	This study confirms the presence of iron, co-localized with Abeta plaques, in PS/APP mouse brain, using Perls" stain for Fe3+ supplemented by 3,3"-diaminobenzidine (DAB) and Abeta immunohistochemistry in histological brains sections fixed with formalin or methacarn.	Iron	36-40	amyloid beta (A4) precursor protein	Mus musculus	174-179
3421902-8	1988	These findings indicate that iron acquired from transferrin and iron acquired by scavenging mechanisms are handled differently, and suggest that more than one intracellular iron transit pool may exist.	Iron	29-33	transferrin	Mus musculus	48-59
15895823-3	2005	The presence of iron in beta-amyloid plaques in PS/APP transgenic mice, a model of Alzheimer"s disease (AD) pathology, may explain previous reports of reductions of transverse relaxation time (T2) in MRI studies and represent the source of the intrinsic Abeta plaque MR contrast in this model.	Iron	16-20	amyloid beta (A4) precursor protein	Mus musculus	254-259
15667655-0	2005	Iron homeostasis in neuronal cells: a role for IREG1.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	47-52
3367157-5	1988	RCA-1 stained microglia and hemosiderin whereas antisera to alpha 1-antitrypsin and alpha 1-antichymotrypsin only reacted with iron-depleted granules.	Iron	127-131	serpin family A member 3	Homo sapiens	84-108
15667655-6	2005	Increased expression of IREG1 was further substantiated by immunocytochemistry and iron efflux experiments.	Iron	83-87	solute carrier family 40 member 1	Homo sapiens	24-29
15667655-7	2005	IREG1 expression directly correlated with iron content in SH-SY5Y and hippocampal cells.	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	0-5
3172177-8	1988	From these results, we propose a hypothesis that lymphocytes may be activated by transferable serum factors such as iron-saturated transferrin and suppression of tumor growth caused by the effector-target interaction which is mediated by effector-associated transferrin in the case of cheese fed mice.	Iron	116-120	transferrin	Mus musculus	131-142
15667655-8	2005	Similarly, a high correlation was found between IREG1 expression and the rate of iron efflux from SH-SY5Y cells.	Iron	81-85	solute carrier family 40 member 1	Homo sapiens	48-53
15667655-9	2005	CONCLUSIONS: Neuronal survival of iron accumulation associates with increased expression of the efflux transporter IREG1.	Iron	34-38	solute carrier family 40 member 1	Homo sapiens	115-120
15667655-10	2005	Thus, the capacity of neurons to express IREG1 may be one of the clues to iron accumulation survival.	Iron	74-78	solute carrier family 40 member 1	Homo sapiens	41-46
3236339-3	1988	A synergistic effect of iron was evident on other parameters too, such as HCB-induced hepatic damage, activation of type O of xanthine oxidase, and decreased activity of copper zinc superoxide dismutase and glutathione peroxidase(s).	Iron	24-28	xanthine dehydrogenase	Mus musculus	126-142
15707062-9	2005	Experimentally measured activation energies for CCl4 reduction by corroding iron correspond to reaction energies that are insufficiently exergonic for promoting the outer-sphere mechanism.	Iron	76-80	C-C motif chemokine ligand 4	Homo sapiens	48-52
3387462-2	1988	protected male mice against CCl4- or CBrCl3-induced hepatotoxicity which is closely related to an inhibition of iron-dependent lipid peroxidation monitored by ethane exhalation.	Iron	112-116	chemokine (C-C motif) ligand 4	Mus musculus	28-32
15707062-10	2005	This suggests that the different reaction pathways that have been observed for CCl4 reduction by corroding iron arise from different catalytic interactions with the surface, and not from differences in energy of the transferred electrons.	Iron	107-111	C-C motif chemokine ligand 4	Homo sapiens	79-83
2449437-1	1988	Ferritin synthesis provides a dramatic example of translational control; stored ferritin mRNA is translated at relatively low rates which can increase 40-50 times when cellular iron levels increase.	Iron	177-181	Fer2	Triticum aestivum	0-8
15933765-1	2005	Heme oxygenase-1 (HO-1) is an enzyme which catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase.	Iron	126-130	heme oxygenase 1	Homo sapiens	0-16
2449437-1	1988	Ferritin synthesis provides a dramatic example of translational control; stored ferritin mRNA is translated at relatively low rates which can increase 40-50 times when cellular iron levels increase.	Iron	177-181	Fer2	Triticum aestivum	80-88
2449437-4	1988	Repression of ferritin mRNA was associated with the inability to form polyribosomes in analogy to iron-poor cells in vivo.	Iron	98-102	Fer2	Triticum aestivum	14-22
15933765-1	2005	Heme oxygenase-1 (HO-1) is an enzyme which catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase.	Iron	126-130	heme oxygenase 1	Homo sapiens	18-22
3191858-18	1988	Furthermore, this rise in intraneuronal mMDH follows the peak of intraneuronal Tf and suggests that Tf supplies the iron required for the synthesis of other mitochondrial ferroproteins.	Iron	116-120	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	40-44
15654801-3	2005	The proximal small bowel is the major site of iron absorption and, it is becoming increasingly clear that the regulation of this process involves the liver and, in particular, the hepatic antimicrobial peptide hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	210-218
15634340-0	2005	Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading.	Iron	104-108	CD1d molecule	Homo sapiens	22-26
3043460-1	1988	The occurrence of an oxo-bridged binuclear iron site is well-established for the oxygen transport protein, hemerythrin, and strongly implicated in ribonucleotide reductase, purple acid phosphatase, ferritin, and methane monooxygenase.	Iron	43-47	acid phosphatase 5, tartrate resistant	Homo sapiens	173-196
3480514-2	1987	A specific iron ion (Fea, which is lost during inactivation) is the binding site for substrate, as shown by Mossbauer spectroscopy.	Iron	11-15	FEA	Homo sapiens	21-24
3445653-3	1987	Since, as a rule, there is no iron deficit in haemodialysis, a secondary damage of the ferrochelatase, which physiologically by administration of iron leads to haem (ferroprotoporphyrin), is assumed as cause of the increase of erythrocytic protoporphyrin.	Iron	146-150	ferrochelatase	Homo sapiens	87-101
3478818-1	1987	Lactotransferrin (LTF), a member of the transferrin family of genes, is the major iron-binding protein in milk and body secretions.	Iron	82-86	transferrin	Mus musculus	5-16
3040731-2	1987	Soybean lipoxygenase is a non-heme iron enzyme that catalyzes the hydroperoxidation of linoleic acid by dioxygen.	Iron	35-39	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3036864-4	1987	The freezing of fresh CCP induces the reversible coordination of an internal strong field ligand to the heme iron to form a hexa-coordinated low spin compound, which shows EPR extrema at gx = 2.70, gy = 2.20 and gz = 1.78.	Iron	109-113	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	22-25
3036864-6	1987	Upon aging CCP is converted to a hexa-coordinated high spin state due to the coordination of an internal weak field ligand to the heme iron.	Iron	135-139	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	11-14
3595766-6	1987	The deficiency in the uptake of iron by affected reticulocytes was not observed on incubation at 4 degrees C. Scatchard analysis of transferrin receptors on hbd/hbd and control reticulocytes showed no difference in pKD and a slight elevation in number of receptors per reticulocyte for hbd/hbd animals.	Iron	32-36	transferrin	Mus musculus	132-143
3595766-7	1987	These findings suggest that hbd/hbd reticulocytes have a defect in iron acquisition that is distal to the binding of transferrin to the cell membrane receptor.	Iron	67-71	transferrin	Mus musculus	117-128
3472216-0	1987	Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis.	Iron	68-72	transferrin	Mus musculus	50-61
3472216-7	1987	In the transferrin iron-saturated animals, injected 59Fe accumulated in the liver and pancreas.	Iron	19-23	transferrin	Mus musculus	7-18
3472216-8	1987	Gastrointestinally absorbed iron in hypotransferrinemic or transferrin iron-saturated mice was deposited in the liver.	Iron	28-32	transferrin	Mus musculus	40-51
3472216-11	1987	In transferrin iron-saturated animals, injected 59Fe was removed with a half-time of less than 30 s. Analysis of the distribution of 59Fe in serum samples by polyacrylamide gel electrophoresis demonstrated the presence of 59Fe not bound to transferrin.	Iron	15-19	transferrin	Mus musculus	3-14
3472216-12	1987	These results demonstrate the existence of and an uptake system for non-transferrin-bound iron.	Iron	90-94	transferrin	Mus musculus	72-83
3327439-3	1987	A variety of biochemical and clinical evidence viewed in toto now suggests that ferrochelatase catalyzes zinc protoporphyrin formation in states of relative iron-deficient erythropoiesis and in lead-inhibited iron metabolism.	Iron	157-161	ferrochelatase	Homo sapiens	80-94
3609531-3	1987	Its role in this process is restricted exclusively to iron transport, which takes place by receptor-mediated endocytosis of iron-loaded transferrin.	Iron	54-58	transferrin	Mus musculus	136-147
3609531-3	1987	Its role in this process is restricted exclusively to iron transport, which takes place by receptor-mediated endocytosis of iron-loaded transferrin.	Iron	124-128	transferrin	Mus musculus	136-147
3609531-9	1987	The abundant binding of transferrin in areas of active cell proliferation in bell-stage teeth also suggests that transferrin is still needed and used for the transport of iron into proliferating cells.	Iron	171-175	transferrin	Mus musculus	24-35
3609531-9	1987	The abundant binding of transferrin in areas of active cell proliferation in bell-stage teeth also suggests that transferrin is still needed and used for the transport of iron into proliferating cells.	Iron	171-175	transferrin	Mus musculus	113-124
3609531-11	1987	After releasing iron into a cell, transferrin is returned to the extracellular space and is reused.	Iron	16-20	transferrin	Mus musculus	34-45
2462531-4	1987	This indicates that a nuclear NADPH-enzyme, presumably NADPH-cytochrome P-450 reductase, is able to redox cycle a bleomycin-iron-complex which in the reduced form can activate oxygen to a DNA-damaging reactive species.	Iron	124-128	cytochrome p450 oxidoreductase	Rattus norvegicus	55-87
3561619-6	1987	We conclude that the risk of developing iron overload is greater in hemodialysis patients with HLA A3, B7 or B14.	Iron	40-44	NADH:ubiquinone oxidoreductase subunit A6	Homo sapiens	109-112
3616359-3	1987	Its definition requires: a) a family history of abnormalities of iron storage; b) an association with HLA; c) inadequate iron absorption in relation to iron stores in liver and other territories; d) the absence of any other known causes of iron overload.	Iron	121-125	major histocompatibility complex, class I, C	Homo sapiens	102-108
3616359-3	1987	Its definition requires: a) a family history of abnormalities of iron storage; b) an association with HLA; c) inadequate iron absorption in relation to iron stores in liver and other territories; d) the absence of any other known causes of iron overload.	Iron	121-125	major histocompatibility complex, class I, C	Homo sapiens	102-108
3616359-3	1987	Its definition requires: a) a family history of abnormalities of iron storage; b) an association with HLA; c) inadequate iron absorption in relation to iron stores in liver and other territories; d) the absence of any other known causes of iron overload.	Iron	121-125	major histocompatibility complex, class I, C	Homo sapiens	102-108
9939460-0	1986	Spin-polarized photoemission from iron by pulsed laser radiation.	Iron	34-38	spindlin 1	Homo sapiens	0-4
15634340-4	2005	Iron loading of HepG2 cells resulted in increased expression of Nor3.2-reactive CD1d molecules at the plasma membrane.	Iron	0-4	CD1d molecule	Homo sapiens	80-84
15634340-7	2005	Interestingly, increased expression of CD1d molecules by iron-loaded HepG2 cells was associated with increased phosphatidylserine expression in the outer leaflet of the plasma membrane and the presence of many intracellular lipid droplets.	Iron	57-61	CD1d molecule	Homo sapiens	39-43
15634340-8	2005	These data describe a new relationship between iron loading, lipid accumulation and altered expression of CD1d, an unconventional MHC class I molecule reported to monitor intracellular and plasma membrane lipid metabolism, in the human hepatoma cell line HepG2.	Iron	47-51	CD1d molecule	Homo sapiens	106-110
15589375-1	2005	Heme oxygenases (HO-1 and HO-2) catalyze the NADPH-cytochrome P(450) reductase (CPR)-dependent degradation of heme into iron, carbon monoxide, and biliverdin, which is reduced into bilirubin.	Iron	120-124	heme oxygenase 1	Homo sapiens	0-30
16187331-6	2005	Iron deficient slices retained a developmentally immature P15 pattern of LTP expression at P30 and after iron repletion, and LTP expression was lower (P &lt; 0.05) in the iron deficient group at P65.	Iron	0-4	cyclin-dependent kinase inhibitor 2B	Rattus norvegicus	58-61
15893120-4	2005	Upregulation of hepcidin causes anemia by a number of mechanisms: decreased intestinal absorption of iron from the duodenum, increased sequestration of iron by macrophages.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	16-24
15893120-4	2005	Upregulation of hepcidin causes anemia by a number of mechanisms: decreased intestinal absorption of iron from the duodenum, increased sequestration of iron by macrophages.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	16-24
15632423-7	2005	Pyrite- and sulfur-grown cells contained high levels of the cbsA transcript, which encodes a membrane-bound cytochrome b with a possible role in iron oxidation or chemolithotrophy.	Iron	145-149	cytochrome bc complex cytochrome b subunit	Metallosphaera sedula	108-120
15610558-1	2004	BACKGROUND: Homozygosity or compound heterozygosity for coding region mutations of the hemojuvelin gene (HJV) in whites is a cause of early age-of-onset iron overload (juvenile hemochromatosis), and of hemochromatosis phenotypes in some young or middle-aged adults.	Iron	153-157	hemojuvelin BMP co-receptor	Homo sapiens	87-98
15610558-1	2004	BACKGROUND: Homozygosity or compound heterozygosity for coding region mutations of the hemojuvelin gene (HJV) in whites is a cause of early age-of-onset iron overload (juvenile hemochromatosis), and of hemochromatosis phenotypes in some young or middle-aged adults.	Iron	153-157	hemojuvelin BMP co-receptor	Homo sapiens	105-108
15610558-2	2004	HJV coding region mutations have also been identified recently in African American primary iron overload and control subjects.	Iron	91-95	hemojuvelin BMP co-receptor	Homo sapiens	0-3
15610558-11	2004	CONCLUSIONS: HJV I222N and G320V are probably uncommon causes or modifiers of primary iron overload in adult whites and African Americans in Alabama.	Iron	86-90	hemojuvelin BMP co-receptor	Homo sapiens	13-16
15514116-0	2004	Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	0-8
15514116-1	2004	Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
15514116-2	2004	Decreased hepcidin leads to tissue iron overload, whereas hepcidin overproduction leads to hypoferremia and the anemia of inflammation.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	10-18
15514116-6	2004	The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	51-59
15514116-6	2004	The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	130-138
15319276-1	2004	Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis.	Iron	55-59	transferrin receptor 2	Homo sapiens	125-129
15317665-2	2004	Mutations in TfR2 result in hemochromatosis, indicating that this receptor has a unique role in iron metabolism.	Iron	96-100	transferrin receptor 2	Homo sapiens	13-17
15317665-8	2004	Tf delivered by TfR2 does not appear to be degraded, which suggests that its delivery to this organelle may be functionally relevant to the storage of iron in overloaded states.	Iron	151-155	transferrin receptor 2	Homo sapiens	16-20
15659834-5	2004	In this study, we investigated the effect of cyPGs on the expression of heme oxygenase-1 (HO-1), a ubiquitous stress-responsive enzyme that catalyzes oxidative cleavage of heme to form iron, carbon monoxide, and biliverdin.	Iron	185-189	heme oxygenase 1	Homo sapiens	72-88
15659834-5	2004	In this study, we investigated the effect of cyPGs on the expression of heme oxygenase-1 (HO-1), a ubiquitous stress-responsive enzyme that catalyzes oxidative cleavage of heme to form iron, carbon monoxide, and biliverdin.	Iron	185-189	heme oxygenase 1	Homo sapiens	90-94
15501550-5	2004	Recent studies have demonstrated that hepcidin is a key regulator of iron balance in the intestinal mucosa, and that abnormalities in hepcidin gene expression are associated with clinical abnormalities in iron parameters and, in some cases, with anaemia.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	38-46
15501550-5	2004	Recent studies have demonstrated that hepcidin is a key regulator of iron balance in the intestinal mucosa, and that abnormalities in hepcidin gene expression are associated with clinical abnormalities in iron parameters and, in some cases, with anaemia.	Iron	205-209	hepcidin antimicrobial peptide	Homo sapiens	134-142
15501550-9	2004	It seems very likely that hepcidin is a major contributor to iron abnormalities characteristic of ACD; whether it contributes to the pathogenesis of the syndrome in a broader sense remains to be determined by further investigation.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	26-34
15642322-11	2004	Initial upregulation of message for HO-1 occurred a few hours before any upregulation of MnSOD could be detected, suggesting that release of free iron from the degradation of heme by HO-1 may have played a role in the upregulation of the dismutase.	Iron	146-150	heme oxygenase 1	Homo sapiens	36-40
15642322-11	2004	Initial upregulation of message for HO-1 occurred a few hours before any upregulation of MnSOD could be detected, suggesting that release of free iron from the degradation of heme by HO-1 may have played a role in the upregulation of the dismutase.	Iron	146-150	heme oxygenase 1	Homo sapiens	183-187
15815081-3	2004	Three probes (I-III) containing a photo-labile azido-group and an amino-group on opposite ends of the molecule were designed for photoaffinity labeling of the CYP 2B4 in increasing distance from the heme iron.	Iron	204-208	cytochrome P450 2B4	Oryctolagus cuniculus	159-166
15815081-7	2004	The target of photoactivated probe II, Arg 197, in a distance of about 16.5 A from the heme iron, exactly matches the position of that amino acid residue, predicted from the CYP 2B4 homology model.	Iron	92-96	cytochrome P450 2B4	Oryctolagus cuniculus	174-181
15501547-2	2004	As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades.	Iron	67-69	MS2	Homo sapiens	126-129
15465629-1	2004	Metals such as zinc, copper and iron contribute to aggregation of amyloid-beta (Abeta) protein and deposition of amyloid plaques in Alzheimer"s disease (AD).	Iron	32-36	amyloid beta (A4) precursor protein	Mus musculus	80-85
15493939-1	2004	Reduction of the five-coordinate iron(II) dihalide complexes (iPrPDI)FeX2 (iPrPDI = ((2,6-CHMe2)2C6H3N=CMe)2C5H3N; X = Cl, Br) with sodium amalgam under 1 atm of dinitrogen afforded the square pyramidal, high spin iron(0) bis(dinitrogen) complex (iPrPDI)Fe(N2)2.	Iron	33-37	stabilin 2	Homo sapiens	69-73
15297453-1	2004	Human heme oxygenase-1 (hHO-1) catalyzes the O2-dependent oxidation of heme to biliverdin, CO, and free iron.	Iron	104-108	heme oxygenase 1	Homo sapiens	6-22
16665148-6	1986	The incorporation of iron-59 from the nutrient medium into lipoxygenase during culture of immature seeds was indicative of de novo synthesis of the enzyme.	Iron	21-25	linoleate 9S-lipoxygenase-4	Glycine max	59-71
15297453-1	2004	Human heme oxygenase-1 (hHO-1) catalyzes the O2-dependent oxidation of heme to biliverdin, CO, and free iron.	Iron	104-108	heme oxygenase 1	Homo sapiens	24-29
16665148-7	1986	The efficiency of the iron uptake was high, as indicated by the level of radioactivity found in the enzyme (one gram atom of iron per mole of lipoxygenase).	Iron	22-26	linoleate 9S-lipoxygenase-4	Glycine max	142-154
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	102-115
16665148-7	1986	The efficiency of the iron uptake was high, as indicated by the level of radioactivity found in the enzyme (one gram atom of iron per mole of lipoxygenase).	Iron	125-129	linoleate 9S-lipoxygenase-4	Glycine max	142-154
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	117-122
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	102-115
15178542-2	2004	Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1).	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	117-122
3821722-7	1986	Uteroferrin, although implicated in transplantal iron transport, also possesses many of the properties of a lysosomal enzyme and, when newly synthesized, carries the so-called lysosomal recognition marker, mannose 6-phosphate.	Iron	49-53	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
15178542-12	2004	We conclude that, toward the end of the third trimester of iron-sufficient human pregnancy, the placenta accumulates ferritin and potentially increases placental-fetal iron delivery through increased FPN-1 expression.	Iron	59-63	solute carrier family 40 member 1	Homo sapiens	200-205
15198949-3	2004	Hepcidin is considered to constitute a negative regulator of iron absorption, and its production is increased in inflammatory states and iron overload.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
9940459-0	1986	Spin-dependent momentum distribution in iron studied with circularly polarized synchrotron radiation.	Iron	40-44	spindlin 1	Homo sapiens	0-4
15198949-3	2004	Hepcidin is considered to constitute a negative regulator of iron absorption, and its production is increased in inflammatory states and iron overload.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	0-8
3527760-0	1986	Role of uteroferrin in transplacental iron transport in the pig.	Iron	38-42	acid phosphatase 5, tartrate resistant	Sus scrofa	8-19
15198949-7	2004	The decrease of hepcidin production would thus lead to increased iron absorption, resulting in iron deposition in parenchymal tissues.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	16-24
3527760-3	1986	This protein, uteroferrin, is induced by progesterone; is purple, which results from an unusual iron center; and possesses acid phosphatase activity.	Iron	96-100	acid phosphatase 5, tartrate resistant	Sus scrofa	14-25
3527760-5	1986	Uteroferrin then enters the placental venous drainage and its iron is efficiently incorporated into fetal hemoglobin.	Iron	62-66	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
15198949-7	2004	The decrease of hepcidin production would thus lead to increased iron absorption, resulting in iron deposition in parenchymal tissues.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	16-24
3527760-8	1986	From the kidney uteroferrin enters the allantoic sac where it exchanges its iron with fetal transferrin.	Iron	76-80	acid phosphatase 5, tartrate resistant	Sus scrofa	16-27
15461631-6	2004	One patient with severe iron overload was found to be a compound heterozygote for HJV mutations, one of which had previously been identified in patients with juvenile haemochromatosis (G320V) and the other was novel (C321W).	Iron	24-28	hemojuvelin BMP co-receptor	Homo sapiens	82-85
3527760-9	1986	The rate of uteroferrin biosynthesis in the uterus and its rate of metabolism in the fetus can theoretically provide sufficient iron for the needs of pregnancy, at least until around day 70 of the 115-day gestation.	Iron	128-132	acid phosphatase 5, tartrate resistant	Sus scrofa	12-23
15249981-3	2004	Iron uptake in monocytes was proven by histology, quantified by atomic emission absorption spectrometry and depicted with T2* weighted fast field echo (FFE) MR images at 1.5 T. Additionally, induction of apoptosis in iron oxide labeled monocytes was determined by YO-PRO-1 staining.	Iron	0-4	lamin A/C	Homo sapiens	267-272
3730391-6	1986	The increase in the T conformer population of imidazole methemoglobin, which is pure low-spin, suggests that the appearance of the T state with decreasing temperature is not directly coupled to an increase in spin of the heme iron.	Iron	226-230	hemoglobin subunit gamma 2	Homo sapiens	56-69
3697381-2	1986	The rate of iron release from thioglycollate-elicited mouse peritoneal macrophages pulsed with 59Fe-labelled transferrin-antitransferrin immune complexes was lower than that from resident or Corynebacterium parvum-activated macrophages.	Iron	12-16	transferrin	Mus musculus	109-120
15466004-2	2004	Hepcidin is an antimicrobial peptide that plays a key role in regulating intestinal iron absorption.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
15365174-0	2004	Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.	Iron	66-70	ceruloplasmin	Mus musculus	14-27
15327944-5	2004	Cytosolic aconitase (aco-1), iron regulatory protein, is known to regulate cellular iron concentration by modulating translation of the ferritin mRNA in addition to its enzymatic activity that converts citrate into iso-citrate.	Iron	29-33	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	21-26
15508404-5	2004	The redox state of iron is determined by xanthine oxidase, cytochromes and Hp or ceruloplasmin and ferroxidase activity of apo-ferritin, respectively.	Iron	19-23	ceruloplasmin	Homo sapiens	81-94
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	34-38	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	201-205
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	56-60	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	201-205
15449310-10	2004	The roles of OGG1 and NTG2 genes in the repair of lethal and mutagenic oxidative lesions induced by H2O2 and their relationships with iron and copper ions are discussed.	Iron	134-138	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	13-17
15354085-5	2004	Retinas deficient in the ferroxidases, ceruloplasmin and hephaestin, accumulate iron in their retinas and RPE, while retinas deficient in iron regulatory proteins (IRPs) lack the ability to regulate several proteins involved in iron metabolism; retinas from these knockout mice along with their age matched wild type littermates were also examined to study regulation of ferritin and ferroportin.	Iron	80-84	ceruloplasmin	Mus musculus	39-52
15354085-9	2004	Iron accumulation in mice deficient in ceruloplasmin and hephaestin was associated with upregulation of ferritin and ferroportin.	Iron	0-4	ceruloplasmin	Mus musculus	39-52
15161905-3	2004	Overexpression of MRS3 or MRS4 suppresses the high iron sensitivity of Deltaccc1 cells.	Iron	51-55	Fe(2+) transporter	Saccharomyces cerevisiae S288C	26-30
15161905-5	2004	We demonstrate that deletion of MRS3 and MRS4 severely affects cellular and mitochondrial metal homeostasis, including a reduction in cytosolic and mitochondrial iron acquisition.	Iron	162-166	Fe(2+) transporter	Saccharomyces cerevisiae S288C	41-45
15247188-0	2004	Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis.	Iron	51-55	solute carrier family 11 member 2	Homo sapiens	10-14
15231239-4	2004	These findings indicate aberrations in iron homeostasis that, we suspect, arise primarily from heme, since heme oxygenase-1, an enzyme that catalyzes the conversion of heme to iron and biliverdin, is increased in AD, and mitochondria, since mitochondria turnover, mitochondrial DNA, and cytochrome C oxidative activity are all increased in AD.	Iron	39-43	heme oxygenase 1	Homo sapiens	107-123
15231239-4	2004	These findings indicate aberrations in iron homeostasis that, we suspect, arise primarily from heme, since heme oxygenase-1, an enzyme that catalyzes the conversion of heme to iron and biliverdin, is increased in AD, and mitochondria, since mitochondria turnover, mitochondrial DNA, and cytochrome C oxidative activity are all increased in AD.	Iron	176-180	heme oxygenase 1	Homo sapiens	107-123
15229154-0	2004	Potential utility of Ret-Y in the diagnosis of iron-restricted erythropoiesis.	Iron	47-51	ret proto-oncogene	Homo sapiens	21-24
15314524-0	2004	Hepcidin in iron metabolism.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	0-8
15314524-1	2004	PURPOSE OF REVIEW: Hepcidin is a recently discovered hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport across the placenta.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	19-27
15314524-1	2004	PURPOSE OF REVIEW: Hepcidin is a recently discovered hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport across the placenta.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	19-27
15314524-3	2004	Connecting iron metabolism to innate immunity, hepcidin is a key mediator of hypoferremia of inflammation.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	47-55
15314524-5	2004	SUMMARY: Studies of hepcidin are leading to fundamental understanding of iron homeostasis and pointing to potential treatments for hemochromatosis and anemia of inflammation (anemia of chronic disease).	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	20-28
15233805-3	2004	HO-1 catalyzes heme breakdown to release iron, carbon monoxide, and biliverdin, which is reduced to bilirubin, a potent radical scavenger.	Iron	41-45	heme oxygenase 1	Homo sapiens	0-4
15219985-4	2004	Structural comparison with cytochrome P450 from S. solfataricus (CYP119) suggests that the region composed of the F to G helices and the Cl- binding site is responsible for the affinity for a ligand coordinating heme iron.	Iron	217-221	cytochrome P450	Sulfurisphaera tokodaii str. 7	27-42
15219989-0	2004	Hydroxylamine and hydrazine bind directly to the heme iron of the heme-heme oxygenase-1 complex.	Iron	54-58	heme oxygenase 1	Homo sapiens	71-87
15082228-8	2004	Although, the MAO-mediated metabolism of DA increases MAO-B activity, the presence of iron inhibits both MAO-A and MAO-B activities.	Iron	86-90	monoamine oxidase A	Homo sapiens	105-110
15196918-4	2004	In the CO-bound form of OxdA, the correlation between the Fe-CO stretching (512 cm(-1)) and C-O stretching (1950 cm(-1)) frequencies also supports our assignment of proximal histidine coordination.	Iron	58-60	D-amino acid oxidase	Homo sapiens	24-28
15222466-0	2004	Lactoferrin: role in iron homeostasis and host defense against microbial infection.	Iron	21-25	lactotransferrin	Mus musculus	0-11
15222466-3	2004	Although structurally related to transferrin, LF appears to have a broader functional role mediated by both iron dependent and iron independent mechanisms.	Iron	108-112	lactotransferrin	Mus musculus	46-48
15222466-3	2004	Although structurally related to transferrin, LF appears to have a broader functional role mediated by both iron dependent and iron independent mechanisms.	Iron	127-131	lactotransferrin	Mus musculus	46-48
15222466-4	2004	In this review, we will focus on our current understanding on the role of LF in regulating iron homeostasis and its role in host protection against microbial infection at the mucosal surface.	Iron	91-95	lactotransferrin	Mus musculus	74-76
15222471-1	2004	One component of the anti-microbial function of lactoferrin (Lf) is its ability to sequester iron from potential pathogens.	Iron	93-97	HLF transcription factor, PAR bZIP family member	Homo sapiens	61-63
15222471-3	2004	This mechanism involves surface receptors capable of specifically binding Lf from the host, removing iron and transporting it across the outer membrane.	Iron	101-105	HLF transcription factor, PAR bZIP family member	Homo sapiens	74-76
3948154-0	1986	Iron-induced L1210 cell growth: evidence of a transferrin-independent iron transport.	Iron	0-4	transferrin	Mus musculus	46-57
15222471-8	2004	We propose that the receptor proteins, LbpA and LbpB, induce conformational changes in human Lf (hLf) that lower its affinity for iron that binding by FbpA can drive the transport across the outer membrane, a mechanism shared with transferrin (Tf) receptors.	Iron	130-134	HLF transcription factor, PAR bZIP family member	Homo sapiens	93-95
3948154-0	1986	Iron-induced L1210 cell growth: evidence of a transferrin-independent iron transport.	Iron	70-74	transferrin	Mus musculus	46-57
3948154-4	1986	This transferrin-independent iron transport coexisted with transferrin-mediated iron uptake.	Iron	29-33	transferrin	Mus musculus	5-16
3948154-4	1986	This transferrin-independent iron transport coexisted with transferrin-mediated iron uptake.	Iron	80-84	transferrin	Mus musculus	5-16
3948154-4	1986	This transferrin-independent iron transport coexisted with transferrin-mediated iron uptake.	Iron	80-84	transferrin	Mus musculus	59-70
3948154-5	1986	When the iron concentration in the medium is less than 0.1 microM, transferrin must be present in the culture medium in order to observe cell growth.	Iron	9-13	transferrin	Mus musculus	67-78
15222471-8	2004	We propose that the receptor proteins, LbpA and LbpB, induce conformational changes in human Lf (hLf) that lower its affinity for iron that binding by FbpA can drive the transport across the outer membrane, a mechanism shared with transferrin (Tf) receptors.	Iron	130-134	HLF transcription factor, PAR bZIP family member	Homo sapiens	97-100
15222473-4	2004	Moreover, both iron-saturation of the protein and LPS addition strongly inhibit the bovine lactoferrin activity.	Iron	15-19	lactotransferrin	Bos taurus	91-102
15222475-4	2004	Exploiting the ability of bovine lactoferrin (bLf) to bind iron we have found that the TTS of EIEC strain HN280 seems to be activated in conditions of low-iron availability, obtained by incubation of bacteria with bLf enclosed within a dialysis bag.	Iron	59-63	lactotransferrin	Bos taurus	33-44
3712215-2	1986	The purified protein, designated as LC-2, was identified as a variant of mouse transferrin, which is a serum beta 1-globulin having an iron-binding capacity.	Iron	135-139	transferrin	Mus musculus	79-90
15222475-4	2004	Exploiting the ability of bovine lactoferrin (bLf) to bind iron we have found that the TTS of EIEC strain HN280 seems to be activated in conditions of low-iron availability, obtained by incubation of bacteria with bLf enclosed within a dialysis bag.	Iron	155-159	lactotransferrin	Bos taurus	33-44
15222477-9	2004	Both these activities of lactoferrin, related and unrelated to the iron binding capability, could have a key role in protecting the human oral cavity from S. mutans pathogenicity.	Iron	67-71	lactotransferrin	Bos taurus	25-36
14982873-3	2004	The recently identified causal gene encodes hemojuvelin, a protein with a proposed crucial role in iron metabolism.	Iron	99-103	hemojuvelin BMP co-receptor	Homo sapiens	44-55
3272341-0	1986	Isolation of the iron-sulfur-containing polypeptides of NADH: oxidoreductase ubiquinone.	Iron	17-21	thioredoxin reductase 1	Homo sapiens	62-76
14982873-4	2004	A second, rare type of JH, with clinical expression identical to the 1q-linked form, is due to inactivation of hepcidin, the key regulator of iron homeostasis.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	111-119
15043943-1	2004	Hepcidin is an antimicrobial peptide and iron-regulatory molecule that is conserved among vertebrates.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
4063392-6	1985	The availability of the mitochondrial iron pool for heme synthesis by mitochondria in vitro was studied using a recently developed HPLC method for the assay of ferrochelatase activity.	Iron	38-42	ferrochelatase	Homo sapiens	160-174
4063392-12	1985	The possibility that the mitochondrial iron pool functions as the proximate iron donor for heme synthesis by ferrochelatase in vivo is discussed.	Iron	39-43	ferrochelatase	Homo sapiens	109-123
4063392-12	1985	The possibility that the mitochondrial iron pool functions as the proximate iron donor for heme synthesis by ferrochelatase in vivo is discussed.	Iron	76-80	ferrochelatase	Homo sapiens	109-123
15145458-1	2004	Lactoferrin is an important biological molecule with many functions such as modulation of the inflammatory response, iron metabolism and antimicrobial defense.	Iron	117-121	lactotransferrin	Bos taurus	0-11
4075439-0	1985	The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity.	Iron	12-16	chemokine (C-C motif) ligand 4	Mus musculus	41-45
4075439-3	1985	Pretreatment with the iron-chelating agent desferrioxamine (DFO) clearly suppressed lipid peroxidation in all cases, but inhibited only the CCl4-induced hepatotoxicity.	Iron	22-26	chemokine (C-C motif) ligand 4	Mus musculus	140-144
15240935-3	2004	Lactoferrin (LF), a member of the TF family protein, is an iron-binding protein that is found in most biological fluids of mammals.	Iron	59-63	lactotransferrin	Bos taurus	0-11
4058979-3	1985	In contrast, concentrations of the cytochrome pigments a + a3, and c + c1 were normal and cytochrome b was slightly reduced (18%) in the mitochondrial preparations from the iron-deficient animals.	Iron	173-177	cytochrome b, mitochondrial	Rattus norvegicus	90-102
15123426-13	2004	G-CSF-induced changes in the level of LIP and ROS formation could be blocked by pretreatment with iron chelators that repressed the expression of H-ferritin.	Iron	98-102	colony stimulating factor 3	Homo sapiens	0-5
2412562-6	1985	These results indicate that oxy radicals are formed after reduction of the bleomycin-Fe-complex by NADPH-cytochrome P-450 reductase.	Iron	85-87	cytochrome p450 oxidoreductase	Rattus norvegicus	99-131
15123426-14	2004	In addition, the phosphorylation of STAT3 induced by G-CSF was decreased in iron chelator-treated hematopoietic cells.	Iron	76-80	colony stimulating factor 3	Homo sapiens	53-58
15109246-1	2004	Multiple-scattering analysis of X-ray absorption fine structure data on the NO adducts of indoleamine 2,3-dioxygenase (IDO) and analysis of X-ray absorption near-edge structure (XANES) have provided the first direct structural information about the iron center for this ubiquitous mammalian metalloprotein.	Iron	249-253	indoleamine 2,3-dioxygenase 1	Homo sapiens	90-117
3875510-2	1985	The iron-carrying serum protein transferrin is necessary for the early morphogenesis of mouse tooth in organ culture (A-M. Partanen, I. Thesleff, and P. Ekblom, 1984, Differentiation 27, 59-66).	Iron	4-8	transferrin	Mus musculus	32-43
15109246-2	2004	The IDO(II)NO adduct, which is likely to play a physiological role in the immune system, differs from similar adducts such as Mb(II)NO and Lb(II)NO in that the Fe-His bond is essentially broken.	Iron	160-162	indoleamine 2,3-dioxygenase 1	Homo sapiens	4-7
2995452-15	1985	We conclude that O-2 and H2O2 are not sufficient to mediate target cell lysis, but require iron bound to LF, which, in turn, probably generates and focuses toxic O2 radicals, such as OH, to target membrane sites.	Iron	91-95	immunoglobulin kappa variable 1D-39	Homo sapiens	17-20
15109246-7	2004	The results indicate that both the blocking of the heme site to O(2) binding and conformational changes induced by breaking the Fe-N(epsilon) bond may be important mechanisms by which NO inhibits IDO in vitro and in vivo.	Iron	128-132	indoleamine 2,3-dioxygenase 1	Homo sapiens	196-199
15166653-1	2004	BACKGROUND: A decrease in serum ceruloplasmin (Cp), a protein involved in iron metabolism through its ferroxidase activity, is classically claimed to be observed in severe hepatic failure of non-wilsonian chronic liver disease and therefore to be a confounding factor for the diagnosis of Wilson"s disease.	Iron	74-78	ceruloplasmin	Homo sapiens	32-45
2932299-7	1985	Both the EE/NG and FE/DG preparation elevated serum T4 (40%), FT4 (15-22%), T3 (17-28%), and TBG (20%) significant, whereby the effect was more pronounced during the second treatment period after washing-out.	Iron	19-21	serpin family A member 7	Homo sapiens	93-96
2408900-3	1985	Two monoclonal antibodies were used which are able to block the transferrin-mediated uptake of iron by growing cells.	Iron	95-99	transferrin	Mus musculus	64-75
15059075-6	2004	As observed in HFE hemochromatosis, the beta-thalassemia trait seems to aggravate the clinical picture of patients lacking TFR2, favoring higher rates of iron accumulation probably by activation of the erythroid iron regulator.	Iron	212-216	transferrin receptor 2	Homo sapiens	123-127
4001427-5	1985	The iron in methemoglobin is paramagnetic; in combination with water this facilitates T1 relaxation.	Iron	4-8	hemoglobin subunit gamma 2	Homo sapiens	12-25
15082594-1	2004	BACKGROUND AND AIMS: The hepatic peptide hormone hepcidin, which has recently been isolated from human plasma and urine, is thought to be a central regulator of iron homeostasis.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	49-57
15082594-11	2004	CONCLUSIONS: From the detection of pro-hepcidin in human serum, we conclude that the prohormone may be involved in the regulation of iron metabolism in HH.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	39-47
3997841-7	1985	Cyanide and iron-chelators strikingly inhibit the 5-desaturase activity, thus suggesting that 5-desaturase is a metalloenzyme as are other well-characterized cytochrome b5-dependent oxidases.	Iron	12-16	cytochrome b5 type A	Rattus norvegicus	158-171
15111596-8	2004	CONCLUSIONS: Increased mRNA and protein levels of the iron-regulating proteins transferrin, ceruloplasmin, and ferritin are present in glaucoma.	Iron	54-58	ceruloplasmin	Homo sapiens	92-105
3972840-1	1985	Uteroferrin, the iron-containing, progesterone-induced phosphatase of the porcine uterus, is a glycoprotein carrying a single oligosaccharide chain.	Iron	17-21	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
15094311-3	2004	We further found that this gene was also up-regulated by cobalt, hypoxia, the iron chelator (deferoxamine, or DFO), and the prolyl hydroxylase (PH) inhibitor (dimethyloxalyglycine, DMOG), suggesting that hypoxia inducible factor-1alpha (HIF-1alpha) was involved in the up-regulation of this gene.	Iron	78-82	hypoxia inducible factor 1, alpha subunit	Mus musculus	204-235
3972840-5	1985	Uteroferrin is transported across the pig placenta and has been proposed to be involved in iron transfer to the fetus (see Buhi, W. C., Ducsay, C. A., Bazer, F. W., and Roberts, R. M. (1982) J. Biol.	Iron	91-95	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
3972840-14	1985	In the case of uteroferrin this process provides iron to the fetal liver.	Iron	49-53	acid phosphatase 5, tartrate resistant	Sus scrofa	15-26
15094311-3	2004	We further found that this gene was also up-regulated by cobalt, hypoxia, the iron chelator (deferoxamine, or DFO), and the prolyl hydroxylase (PH) inhibitor (dimethyloxalyglycine, DMOG), suggesting that hypoxia inducible factor-1alpha (HIF-1alpha) was involved in the up-regulation of this gene.	Iron	78-82	hypoxia inducible factor 1, alpha subunit	Mus musculus	237-247
2858272-2	1985	The growth promoting action of transferrin was lost when iron was chelated in the culture medium using desferrioxamine.	Iron	57-61	transferrin	Mus musculus	31-42
14720122-2	2004	At least six proteins (IscS, IscU, IscA, HscB, HscA and ferredoxin) have been identified as being essential for the biogenesis of iron-sulphur proteins in bacteria.	Iron	130-134	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	41-45
15051895-9	2004	However, using soluble transferrin receptor (sTfR) levels, we were able to demonstrate an inverse linear relationship (r = 0.37, p = 0.021, n = 41) between Fe status and ceruloplasmin.	Iron	156-158	ceruloplasmin	Homo sapiens	170-183
2983184-3	1985	The results show that the C-11-hydroxyl group is essential for iron binding and DNA damage.	Iron	63-67	RNA polymerase III subunit K	Homo sapiens	26-30
15051895-11	2004	Our data support in vitro results showing regulation of ceruloplasmin by Fe and also suggest that the interactions between Fe and ceruloplasmin should be considered when Fe supplementation is given.	Iron	73-75	ceruloplasmin	Homo sapiens	56-69
15084469-1	2004	Coding region mutations in the principal basolateral iron transporter of the duodenal enterocyte, ferroportin 1 (FPN1), lead to autosomal dominant reticuloendothelial iron overload in humans.	Iron	53-57	solute carrier family 40 member 1	Homo sapiens	98-111
3929541-10	1985	The high activity of acid phosphatase, especially within the chorionic epithelium, seems to be connected with uteroferrin, an iron-binding protein.	Iron	126-130	acid phosphatase 5, tartrate resistant	Sus scrofa	110-121
15084469-1	2004	Coding region mutations in the principal basolateral iron transporter of the duodenal enterocyte, ferroportin 1 (FPN1), lead to autosomal dominant reticuloendothelial iron overload in humans.	Iron	53-57	solute carrier family 40 member 1	Homo sapiens	113-117
14973545-1	2004	Elevated expression of heme oxygenase-1 (HO-1), an intracellular enzyme that degrades heme into carbon monoxide (CO), biliverdine and free iron, has anti-inflammatory and antiapoptotic effects in diverse models.	Iron	139-143	heme oxygenase 1	Homo sapiens	23-39
3885788-1	1985	Uteroferrin, a glycoprotein implicated in transplacental iron transport in the pig, has been localized within the porcine uterus during mid pregnancy by using immunocolloidal gold labeling of sectioned material.	Iron	57-61	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
14973545-1	2004	Elevated expression of heme oxygenase-1 (HO-1), an intracellular enzyme that degrades heme into carbon monoxide (CO), biliverdine and free iron, has anti-inflammatory and antiapoptotic effects in diverse models.	Iron	139-143	heme oxygenase 1	Homo sapiens	41-45
14766239-1	2004	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation releasing iron, carbon monoxide (CO), and biliverdin.	Iron	87-91	heme oxygenase 1	Homo sapiens	0-16
4017900-4	1985	A significant increase in 59Fe incorporation by red blood cells and a decrease in hepatic incorporation of 59Fe indicate a preferential utilization of iron in erythropoiesis among GAA treated animals.	Iron	151-155	alpha glucosidase	Rattus norvegicus	180-183
14766239-1	2004	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation releasing iron, carbon monoxide (CO), and biliverdin.	Iron	87-91	heme oxygenase 1	Homo sapiens	18-22
14699112-4	2004	To access the mechanism of Fe-phytosiderophore acquisition, ZmYS1 was expressed in an iron uptake-defective yeast mutant and in Xenopus oocytes, where ZmYS1-dependent Fe-phytosiderophore transport was stimulated at acidic pH and sensitive to CCCP.	Iron	27-29	iron-phytosiderophore transporter yellow stripe 1	Zea mays	60-65
6517596-5	1984	Iron-dependent lipid peroxidation appears to be responsible for at least part of the conversion of 1-naphthol to predominantly 1,4-naphthoquinone, and it seems likely that superoxide anion radical generation by NADPH-cytochrome P-450 reductase could also catalyze this conversion.	Iron	0-4	cytochrome p450 oxidoreductase	Rattus norvegicus	211-243
6511697-0	1984	Role of uteroferrin in placental iron transport: effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin.	Iron	33-37	acid phosphatase 5, tartrate resistant	Sus scrofa	8-19
6511697-0	1984	Role of uteroferrin in placental iron transport: effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin.	Iron	68-72	acid phosphatase 5, tartrate resistant	Sus scrofa	101-112
6511697-0	1984	Role of uteroferrin in placental iron transport: effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin.	Iron	68-72	acid phosphatase 5, tartrate resistant	Sus scrofa	101-112
6511697-1	1984	Uteroferrin, an Fe-containing, progesterone-induced glycoprotein is involved in maternal to fetal Fe transport in swine.	Iron	16-18	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
6511697-1	1984	Uteroferrin, an Fe-containing, progesterone-induced glycoprotein is involved in maternal to fetal Fe transport in swine.	Iron	98-100	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
14699112-4	2004	To access the mechanism of Fe-phytosiderophore acquisition, ZmYS1 was expressed in an iron uptake-defective yeast mutant and in Xenopus oocytes, where ZmYS1-dependent Fe-phytosiderophore transport was stimulated at acidic pH and sensitive to CCCP.	Iron	27-29	iron-phytosiderophore transporter yellow stripe 1	Zea mays	151-156
14699112-4	2004	To access the mechanism of Fe-phytosiderophore acquisition, ZmYS1 was expressed in an iron uptake-defective yeast mutant and in Xenopus oocytes, where ZmYS1-dependent Fe-phytosiderophore transport was stimulated at acidic pH and sensitive to CCCP.	Iron	86-90	iron-phytosiderophore transporter yellow stripe 1	Zea mays	60-65
6149624-6	1984	The combined measurement of serum ferritin and GGT values should therefore prove useful in epidemiological studies concerned with defining the prevalence in different population groups of the HLA-linked iron-loading gene that leads to the clinical disorder of idiopathic haemochromatosis.	Iron	203-207	inactive glutathione hydrolase 2	Homo sapiens	47-50
15105258-17	2004	In hippocampal CA1, gliosis may associate with synaptic plasticity not modulated by nutritional iron, while cellular damage is sensitive to nutritional iron and zinc.	Iron	152-156	carbonic anhydrase 1	Rattus norvegicus	15-18
15105261-7	2004	Indeed, recent mechanistic studies found that the intestinal transporter for nonheme iron, divalent metal transporter 1 (DMT1), mediates the transport of Pb and Cd.	Iron	85-89	solute carrier family 11 member 2	Homo sapiens	91-119
15105261-7	2004	Indeed, recent mechanistic studies found that the intestinal transporter for nonheme iron, divalent metal transporter 1 (DMT1), mediates the transport of Pb and Cd.	Iron	85-89	solute carrier family 11 member 2	Homo sapiens	121-125
15105261-8	2004	DMT1 is regulated, in part, by dietary iron, and chemical species of Cd and Pb that are transported by DMT1 would be made available through digestion and are also found in plasma.	Iron	39-43	solute carrier family 11 member 2	Homo sapiens	0-4
15105261-9	2004	Accordingly, the involvement of DMT1 in metal uptake offers a mechanistic explanation for why an iron-deficient diet is a risk factor for Pb and Cd poisoning.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	32-36
15105265-5	2004	However, it is clear that the iron bound to lesion-associated proteins such as amyloid-beta and tau plays only a minor, late role in the disease, with the RNA-associated iron found in the neuronal cytoplasm occurring early and being of paramount importance.	Iron	30-34	microtubule associated protein tau	Homo sapiens	96-99
15105272-15	2004	Finally, aceruloplasminemia is an autosomal recessive disorder of iron metabolism caused by loss-of-function mutations in ceruloplasmin gene that leads to misregulation of both systemic and central nervous system iron trafficking.	Iron	66-70	ceruloplasmin	Homo sapiens	10-23
15105274-5	2004	Subsequently, mutations in the ceruloplasmin gene have been determined to result in the excessive iron accumulation seen in the pancreas, retina, and brain.	Iron	98-102	ceruloplasmin	Homo sapiens	31-44
15105274-7	2004	This new disease, "aceruloplasminemia", reveals a role for ceruloplasmin as an essential ferroxidase critical for iron homeostasis.	Iron	114-118	ceruloplasmin	Homo sapiens	20-33
15105274-8	2004	This multicopper oxidase promotes efficient iron efflux such that individuals lacking ceruloplasmin develop a presumed oxidative injury secondary to iron accumulation and significant neuronal damage.	Iron	44-48	ceruloplasmin	Homo sapiens	86-99
15105274-8	2004	This multicopper oxidase promotes efficient iron efflux such that individuals lacking ceruloplasmin develop a presumed oxidative injury secondary to iron accumulation and significant neuronal damage.	Iron	149-153	ceruloplasmin	Homo sapiens	86-99
15105274-9	2004	Aceruloplasminemic mice provide a valuable model to further study the mechanisms by which ceruloplasmin regulates iron trafficking and the role of iron in oxidative injury.	Iron	114-118	ceruloplasmin	Mus musculus	1-14
15105274-9	2004	Aceruloplasminemic mice provide a valuable model to further study the mechanisms by which ceruloplasmin regulates iron trafficking and the role of iron in oxidative injury.	Iron	147-151	ceruloplasmin	Mus musculus	1-14
15105274-12	2004	Further investigation into the mechanisms by which ceruloplasmin regulates iron and copper homeostasis will provide valuable insight into the pathogenesis of metallo-mediated diseases and elucidate mechanisms for transition metal (copper, iron) neuropathology.	Iron	75-79	ceruloplasmin	Homo sapiens	51-64
15105274-12	2004	Further investigation into the mechanisms by which ceruloplasmin regulates iron and copper homeostasis will provide valuable insight into the pathogenesis of metallo-mediated diseases and elucidate mechanisms for transition metal (copper, iron) neuropathology.	Iron	239-243	ceruloplasmin	Homo sapiens	51-64
14629196-0	2004	Role of YHM1, encoding a mitochondrial carrier protein, in iron distribution of yeast.	Iron	59-63	Ggc1p	Saccharomyces cerevisiae S288C	8-12
14629196-7	2004	Mutants of YHM1 converted into rho degrees, consistent with secondary mitochondrial DNA damage from mitochondrial iron accumulation.	Iron	114-118	Ggc1p	Saccharomyces cerevisiae S288C	11-15
14629196-8	2004	In fact, in the Delta yhm1 mutant, iron was found to accumulate in mitochondria.	Iron	35-39	Ggc1p	Saccharomyces cerevisiae S288C	22-26
14629196-10	2004	The phenotypes of Delta yhm1 mutants indicate a role for this mitochondrial transporter in cellular iron homoeostasis.	Iron	100-104	Ggc1p	Saccharomyces cerevisiae S288C	24-28
14735461-1	2004	Heme oxygenase-1 (HO-1), an inducible enzyme that catalyzes oxidative degradation of heme to form biliverdin, carbon monoxide and free iron, may protect tumor cells against oxidative stress, thus contributing to rapid tumor growth in vivo.	Iron	135-139	heme oxygenase 1	Homo sapiens	0-16
15037222-11	2004	CONCLUSIONS: Treatment with the polymeric iron chelator DFX significantly increases survival of septic subjects and alters the expression of bax, an apoptosis regulating protein in certain organs (heart, liver and kidney).	Iron	42-46	BCL2 associated X, apoptosis regulator	Rattus norvegicus	141-144
15287192-1	2004	BACKGROUND: There is now good evidence to suggest that cytochrome P450 (CYP450) may act as an iron-donating catalyst for the production of hydroxyl ion (OH*), which contributes to proximal tubular cell injury.	Iron	94-98	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	55-70
15287192-1	2004	BACKGROUND: There is now good evidence to suggest that cytochrome P450 (CYP450) may act as an iron-donating catalyst for the production of hydroxyl ion (OH*), which contributes to proximal tubular cell injury.	Iron	94-98	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	72-78
15013441-5	2004	The ABCE proteins, postulated to be inhibitors of RNase L, are identified by two potential Fe-S metal-binding domains in addition to two NBDs.	Iron	91-95	ribonuclease L	Homo sapiens	50-57
14769043-2	2004	The two thioether bonds linking protein to heme in cyt c are present in 1, and the native axial ligand His-18 remains coordinated to iron.	Iron	133-137	cytochrome c, somatic	Equus caballus	51-56
14534306-5	2004	New or additional support for a role in copper and iron homeostasis is provided in this study for the gene products of AKR1, MRS4, PCA1, SSU1, TIS11, YBR047W, YHL035C, YHR045W, YLR047C, YLR126C, and YTP1.	Iron	51-55	Fe(2+) transporter	Saccharomyces cerevisiae S288C	125-129
14534306-5	2004	New or additional support for a role in copper and iron homeostasis is provided in this study for the gene products of AKR1, MRS4, PCA1, SSU1, TIS11, YBR047W, YHL035C, YHR045W, YLR047C, YLR126C, and YTP1.	Iron	51-55	Tis11p	Saccharomyces cerevisiae S288C	143-148
14960194-1	2004	INTRODUCTION: Heme oxygenase-1 (HO-1) is a stress response enzyme, which catalyses the breakdown of heme into biliverdin-IX alpha, carbon monoxide and ferrous iron.	Iron	159-163	heme oxygenase 1	Homo sapiens	14-30
14960194-1	2004	INTRODUCTION: Heme oxygenase-1 (HO-1) is a stress response enzyme, which catalyses the breakdown of heme into biliverdin-IX alpha, carbon monoxide and ferrous iron.	Iron	159-163	heme oxygenase 1	Homo sapiens	32-36
15014911-3	2004	The functional properties and localization in plasma membrane of cells and endosomes suggest an important role for the divalent metal transporter DMT1 (also known as DCT1 and Nramp2) in iron transport and cellular iron homeostasis.	Iron	186-190	solute carrier family 11 member 2	Homo sapiens	146-150
15014911-3	2004	The functional properties and localization in plasma membrane of cells and endosomes suggest an important role for the divalent metal transporter DMT1 (also known as DCT1 and Nramp2) in iron transport and cellular iron homeostasis.	Iron	186-190	solute carrier family 11 member 2	Homo sapiens	166-170
15014911-3	2004	The functional properties and localization in plasma membrane of cells and endosomes suggest an important role for the divalent metal transporter DMT1 (also known as DCT1 and Nramp2) in iron transport and cellular iron homeostasis.	Iron	186-190	solute carrier family 11 member 2	Homo sapiens	175-181
15014911-3	2004	The functional properties and localization in plasma membrane of cells and endosomes suggest an important role for the divalent metal transporter DMT1 (also known as DCT1 and Nramp2) in iron transport and cellular iron homeostasis.	Iron	214-218	solute carrier family 11 member 2	Homo sapiens	146-150
15189124-1	2004	Ferritin, a major form of endogenous iron in food legumes such as soybeans, is a novel and natural alternative for iron supplementation strategies where effectiveness is limited by acceptability, cost, or undesirable side effects.	Iron	37-41	ferritin-1, chloroplastic	Glycine max	0-8
15189124-1	2004	Ferritin, a major form of endogenous iron in food legumes such as soybeans, is a novel and natural alternative for iron supplementation strategies where effectiveness is limited by acceptability, cost, or undesirable side effects.	Iron	115-119	ferritin-1, chloroplastic	Glycine max	0-8
15189124-2	2004	A member of the nonheme iron group of dietary iron sources, ferritin is a complex with Fe3+ iron in a mineral (thousands of iron atoms inside a protein cage) protected from complexation.	Iron	24-28	ferritin-1, chloroplastic	Glycine max	60-68
15189124-2	2004	A member of the nonheme iron group of dietary iron sources, ferritin is a complex with Fe3+ iron in a mineral (thousands of iron atoms inside a protein cage) protected from complexation.	Iron	46-50	ferritin-1, chloroplastic	Glycine max	60-68
15189124-2	2004	A member of the nonheme iron group of dietary iron sources, ferritin is a complex with Fe3+ iron in a mineral (thousands of iron atoms inside a protein cage) protected from complexation.	Iron	46-50	ferritin-1, chloroplastic	Glycine max	60-68
15189124-2	2004	A member of the nonheme iron group of dietary iron sources, ferritin is a complex with Fe3+ iron in a mineral (thousands of iron atoms inside a protein cage) protected from complexation.	Iron	46-50	ferritin-1, chloroplastic	Glycine max	60-68
15189124-3	2004	Ferritin illustrates the wide range of chemical and biological properties among nonheme iron sources.	Iron	88-92	ferritin-1, chloroplastic	Glycine max	0-8
15777021-6	2004	The existence of a constitutive haem oxygenase (HO-2), mainly present in the vasculature and nervous system, and an inducible haem oxygenase (HO-1), which is highly expressed during stress conditions in all tissues, also suggests that cells have evolved a fine control of this enzymic pathway to ultimately regulate haem consumption and to ensure production of CO, biliverdin/bilirubin and iron during physiological and pathophysiological situations.	Iron	390-394	heme oxygenase 1	Homo sapiens	142-146
15022609-5	2004	Decreasing concentrations of IL-1, IL-6, TNF-alpha and INF-gamma in IDA patients due to an adequate therapy by iron-containing drugs is a positive phenomenon in recovering the functional status of the immune system; it denotes that the maturation of hemoglobin-containing erythron variations and the secondary immune insufficiency are reviving.	Iron	111-115	interleukin 1 alpha	Homo sapiens	29-33
6092931-1	1984	Some anti-murine transferrin receptor monoclonal antibodies block iron uptake in mouse cell lines and inhibit cell growth.	Iron	66-70	transferrin	Mus musculus	17-28
15570559-1	2004	BACKGROUND: Hepcidin is a recently identified acute phase protein with antimicrobial and iron regulatory functions.	Iron	89-93	hepcidin antimicrobial peptide	Canis lupus familiaris	12-20
6745423-3	1984	The iron-sulfur cluster in the ferredoxin was not only reducible (Nagayama et al., 1983) but also oxidizable in its native form.	Iron	4-8	ferredoxin	Pseudomonas putida	31-41
14657372-7	2003	AtPaO is a Rieske-type iron-sulfur cluster-containing enzyme that is identical to Arabidopsis accelerated cell death 1 and homologous to lethal leaf spot 1 (LLS1) of maize.	Iron	23-27	Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein	Arabidopsis thaliana	157-161
6611185-3	1984	Our studies on the proliferation of a murine T-cell lymphoma (EL-4) showed that the treatment of the ascitic fluid (from the peritoneum of EL-4 bearing mice) with carbonyl iron resulted in a depletion of phagocytes concomitant with a significant increase of [3H] thymidine uptake by EL-4 cells.	Iron	172-176	epilepsy 4	Mus musculus	62-66
6611185-3	1984	Our studies on the proliferation of a murine T-cell lymphoma (EL-4) showed that the treatment of the ascitic fluid (from the peritoneum of EL-4 bearing mice) with carbonyl iron resulted in a depletion of phagocytes concomitant with a significant increase of [3H] thymidine uptake by EL-4 cells.	Iron	172-176	epilepsy 4	Mus musculus	139-143
6611185-3	1984	Our studies on the proliferation of a murine T-cell lymphoma (EL-4) showed that the treatment of the ascitic fluid (from the peritoneum of EL-4 bearing mice) with carbonyl iron resulted in a depletion of phagocytes concomitant with a significant increase of [3H] thymidine uptake by EL-4 cells.	Iron	172-176	epilepsy 4	Mus musculus	139-143
6429041-0	1984	Ceruloplasmin and regulation of transferrin iron during Neisseria meningitidis infection in mice.	Iron	44-48	transferrin	Mus musculus	32-43
6429041-5	1984	This evidence implicated ceruloplasmin activity as an important component in the regulation of the plasma transferrin iron pool and suggested that an important role of additional ceruloplasmin as an acute-phase protein might be related to the requirement of additional transferrin iron.	Iron	118-122	transferrin	Mus musculus	106-117
6429041-5	1984	This evidence implicated ceruloplasmin activity as an important component in the regulation of the plasma transferrin iron pool and suggested that an important role of additional ceruloplasmin as an acute-phase protein might be related to the requirement of additional transferrin iron.	Iron	281-285	transferrin	Mus musculus	269-280
6429041-6	1984	This study also provided further evidence of the importance of transferrin iron and host hypoferremia in bacterial infection.	Iron	75-79	transferrin	Mus musculus	63-74
6327764-9	1984	Iron release from ferritin depends on O-2 because it can be prevented by the addition of superoxide dismutase.	Iron	0-4	immunoglobulin kappa variable 1D-39	Homo sapiens	38-41
12791678-6	2003	The role of AE2 in iron uptake was indicated by three lines of evidence: (i) lack of both iron reduction and iron transport in bicarbonate-free buffer at controlled pH, (ii) failure of HBE cells treated with stilbene AE inhibitors to reduce Fe3+ or transport iron, and (iii) inhibition of iron uptake in HBE cells by inhibition of AE2 protein expression with antisense oligonucleotides.	Iron	19-23	solute carrier family 4 member 2	Homo sapiens	12-15
6327764-11	1984	The efficiency of the iron release increases at low levels of O-2 production.	Iron	22-26	immunoglobulin kappa variable 1D-39	Homo sapiens	62-65
6327764-12	1984	Only O-2 produced by granulocytes is sufficient for iron mobilization, because solid potassium superoxide is also able to release iron from ferritin.	Iron	52-56	immunoglobulin kappa variable 1D-39	Homo sapiens	5-8
12876064-0	2003	Altered dietary iron intake is a strong modulator of renal DMT1 expression.	Iron	16-20	solute carrier family 11 member 2	Homo sapiens	59-63
6425220-1	1984	Hypoferremia, the reduction of plasma transferrin iron levels during infection, has been shown to control Neisseria meningitidis infection in mice.	Iron	50-54	transferrin	Mus musculus	38-49
12876064-1	2003	Divalent metal transporter1 (DMT1; also known as DCT1 or NRAMP2) is an important component of the cellular machinery responsible for dietary iron absorption in the duodenum.	Iron	141-145	solute carrier family 11 member 2	Homo sapiens	0-27
12876064-1	2003	Divalent metal transporter1 (DMT1; also known as DCT1 or NRAMP2) is an important component of the cellular machinery responsible for dietary iron absorption in the duodenum.	Iron	141-145	solute carrier family 11 member 2	Homo sapiens	29-33
12876064-1	2003	Divalent metal transporter1 (DMT1; also known as DCT1 or NRAMP2) is an important component of the cellular machinery responsible for dietary iron absorption in the duodenum.	Iron	141-145	solute carrier family 11 member 2	Homo sapiens	49-53
16663575-0	1984	Cytosolic NADPH is the electron donor for extracellular fe reduction in iron-deficient bean roots.	Iron	56-58	2,4-dienoyl-CoA reductase 1	Homo sapiens	10-15
12876064-1	2003	Divalent metal transporter1 (DMT1; also known as DCT1 or NRAMP2) is an important component of the cellular machinery responsible for dietary iron absorption in the duodenum.	Iron	141-145	solute carrier family 11 member 2	Homo sapiens	57-63
16663575-0	1984	Cytosolic NADPH is the electron donor for extracellular fe reduction in iron-deficient bean roots.	Iron	72-76	2,4-dienoyl-CoA reductase 1	Homo sapiens	10-15
12876064-2	2003	DMT1 is also highly expressed in the kidney where it has been suggested to play a role in urinary iron handling.	Iron	98-102	solute carrier family 11 member 2	Homo sapiens	0-4
16663575-2	1984	In iron-deficient plants, total NADP per gram fresh weight and the NADPH/NADP(+) ratio were twice the values found in iron-sufficient plants.	Iron	3-7	2,4-dienoyl-CoA reductase 1	Homo sapiens	67-72
16663575-3	1984	The NADPH/NADP(+) ratio in iron-deficient plants was considerably lowered after a 2 minute incubation in 1 millimolar ferricyanide.	Iron	27-31	2,4-dienoyl-CoA reductase 1	Homo sapiens	4-9
12876064-3	2003	In this study, we determined the effect on renal DMT1 expression of feeding an iron-restricted diet (50 mg/kg) or an iron-enriched diet (5 g/kg) for 4 wk and measured urinary and fecal iron excretion rates.	Iron	79-83	solute carrier family 11 member 2	Homo sapiens	49-53
16663575-4	1984	Total NAD was not influenced by growth conditions and was mainly present in oxidized form.These results indicate that NADPH is the electron donor for the high Fe(III) reduction activity found in iron-deficient roots, a process that is part of the Fe-uptake mechanism.	Iron	195-199	2,4-dienoyl-CoA reductase 1	Homo sapiens	118-123
16663575-4	1984	Total NAD was not influenced by growth conditions and was mainly present in oxidized form.These results indicate that NADPH is the electron donor for the high Fe(III) reduction activity found in iron-deficient roots, a process that is part of the Fe-uptake mechanism.	Iron	159-161	2,4-dienoyl-CoA reductase 1	Homo sapiens	118-123
12876064-4	2003	Feeding the low-iron diet caused a reduction in serum iron concentration and fecal iron output rate with an increase in renal DMT1 expression.	Iron	16-20	solute carrier family 11 member 2	Homo sapiens	126-130
12876064-6	2003	Therefore, DMT1 expression in the kidney is sensitive to dietary iron intake, and the level of expression is inversely related to the dietary iron content.	Iron	65-69	solute carrier family 11 member 2	Homo sapiens	11-15
12876064-6	2003	Therefore, DMT1 expression in the kidney is sensitive to dietary iron intake, and the level of expression is inversely related to the dietary iron content.	Iron	142-146	solute carrier family 11 member 2	Homo sapiens	11-15
12876064-8	2003	Increased DMT1 expression was accompanied by a decrease in urinary iron excretion rate and vice versa when DMT1 expression was reduced.	Iron	67-71	solute carrier family 11 member 2	Homo sapiens	10-14
6587337-1	1984	Uteroferrin is an iron-containing, progesterone-induced, acid phosphatase that is secreted in large amounts by the uterine endometrium of pigs.	Iron	18-22	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
6587337-6	1984	It is suggested that uteroferrin is a lysosomal enzyme that has assumed a role in iron transport and metabolism and is secreted because the covering N-acetylglucosamine is not removed.	Iron	82-86	acid phosphatase 5, tartrate resistant	Sus scrofa	21-32
12876064-9	2003	Together, these findings suggest that modulation of renal DMT1 expression may influence renal iron excretion rate.	Iron	94-98	solute carrier family 11 member 2	Homo sapiens	58-62
14703689-2	2003	When it is inherited together with a mutation in the HFE (HLA-H) gene associated with hereditary haemochromatosis, iron overload may ensue.	Iron	115-119	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	58-63
6421970-9	1984	Because the amidolytic activity of human thrombin as well as factor Xa, kallikrein, and bovine trypsin was also reversibly suppressed by ferrous sulfate as well as ferric citrate, we consider it likely that the coagulopathy occurring in iron poisoning is the consequence of a general, physiologically important phenomenon: the susceptibility of serine proteases to nontransferrin-bound Fe3+.	Iron	237-241	kallikrein related peptidase 4	Homo sapiens	72-82
12960168-3	2003	These genes, FET3, FTR1, TIS11, SIT1, and FIT2, are involved in the iron uptake pathway.	Iron	68-72	Tis11p	Saccharomyces cerevisiae S288C	25-30
16346490-1	1984	The inactivation of catechol 2,3-dioxygenase from Pseudomonas putida mt-2 by 3-chloro- and 3-fluorocatechol and the iron-chelating agent Tiron (catechol-3,5-disulfonate) was studied.	Iron	116-120	catechol 2,3-dioxygenase	Pseudomonas putida	20-44
12960168-7	2003	The possibility that the Snf1/Snf4 pathway was also involved in the induction of the same set of genes in response to iron starvation was considered.	Iron	118-122	AMP-activated serine/threonine-protein kinase regulatory subunit SNF4	Saccharomyces cerevisiae S288C	30-34
14614458-8	2003	The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.	Iron	83-87	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-25
14614458-8	2003	The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.	Iron	83-87	Fas ligand	Homo sapiens	38-42
14686498-9	2003	However, there were also significant correlations between iron status as indicated by transferrin saturation or serum ferritin levels and SGOT, SGPT, and gamma-glutamyltransferase (GGT) levels.	Iron	58-62	gamma-glutamyltransferase light chain family member 3	Homo sapiens	154-179
14686498-9	2003	However, there were also significant correlations between iron status as indicated by transferrin saturation or serum ferritin levels and SGOT, SGPT, and gamma-glutamyltransferase (GGT) levels.	Iron	58-62	gamma-glutamyltransferase light chain family member 3	Homo sapiens	181-184
14686498-10	2003	Moreover, abnormal liver function as represented by elevated levels of SGOT, SGPT, GGT, and serum alkaline phosphatase was observed more frequently in patients with iron overload than in patients with a lower degree of iron burden.	Iron	165-169	gamma-glutamyltransferase light chain family member 3	Homo sapiens	83-86
14568251-0	2003	The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression.	Iron	16-20	solute carrier family 40 member 1	Homo sapiens	58-70
14568251-0	2003	The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression.	Iron	16-20	solute carrier family 40 member 1	Homo sapiens	71-76
14568251-0	2003	The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression.	Iron	16-20	solute carrier family 40 member 1	Homo sapiens	77-81
14568251-1	2003	BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals.	Iron	85-89	solute carrier family 40 member 1	Homo sapiens	17-21
14568251-1	2003	BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals.	Iron	85-89	solute carrier family 40 member 1	Homo sapiens	22-34
14568251-1	2003	BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals.	Iron	85-89	solute carrier family 40 member 1	Homo sapiens	35-40
14568251-1	2003	BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals.	Iron	85-89	solute carrier family 40 member 1	Homo sapiens	61-68
14568251-3	2003	The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron.	Iron	104-108	solute carrier family 40 member 1	Homo sapiens	72-79
14568251-8	2003	Then, in cells transfected with SLC40A1-DeltaIRE-Luc, we found that, in spite of iron regulatory protein activation, the response to iron manipulation was lost.	Iron	81-85	solute carrier family 40 member 1	Homo sapiens	32-39
14568251-9	2003	CONCLUSIONS: We demonstrate that the iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system.	Iron	37-41	solute carrier family 40 member 1	Homo sapiens	68-75
14568251-9	2003	CONCLUSIONS: We demonstrate that the iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system.	Iron	156-160	solute carrier family 40 member 1	Homo sapiens	68-75
14615726-7	2003	RESULTS: Iron supplementation resulted in higher hemoglobin and mean corpuscular volume at 6 months of age and significantly higher visual acuity and PDI at 13 months of age (100+/-12 vs 93+/-9 [+/-SD]).	Iron	9-13	peptidyl arginine deiminase 1	Homo sapiens	150-153
14580376-6	2003	A 6.8 kb fragment of the TGF-beta 3 promoter induced reporter gene expression under hypoxic conditions or when treated with an iron chelator known to stabilize and activate the HIF-1 alpha subunit.	Iron	127-131	transforming growth factor, beta 3	Mus musculus	25-35
14580376-6	2003	A 6.8 kb fragment of the TGF-beta 3 promoter induced reporter gene expression under hypoxic conditions or when treated with an iron chelator known to stabilize and activate the HIF-1 alpha subunit.	Iron	127-131	hypoxia inducible factor 1, alpha subunit	Mus musculus	177-188
14564671-0	2003	Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice.	Iron	8-12	hepcidin antimicrobial peptide 2	Mus musculus	31-47
14564671-5	2003	Both Hepc 1 and Hepc 2 expression responds coordinately to dietary iron.	Iron	67-71	hepcidin antimicrobial peptide 2	Mus musculus	16-22
13678672-6	2003	In contrast, trkB antisense oligonucleotides and inhibitors of Trk tyrosine kinase blocked BDNF-triggered neuronal death as well as BDNF potentiation of iron-induced oxidative neuronal necrosis, suggesting a critical role for TrkB in this phenomenon.	Iron	153-157	brain derived neurotrophic factor	Mus musculus	132-136
12970193-3	2003	Depletion of the cysteine desulfurase Nfs1p, the ferredoxin Yah1p or the yeast frataxin homologue Yfh1p by regulated gene expression causes a strong decrease in the de novo synthesis of Fe/S clusters on Isu1p.	Iron	186-188	adrenodoxin	Saccharomyces cerevisiae S288C	60-65
12970194-2	2003	A genetic screen to isolate Saccharomyces cerevisiae strains bearing mutations in genes required for the conversion of IRP1 to c-aconitase led to the identification of a previously uncharacterized, essential gene, which we call CFD1 (cytosolic Fe-S cluster deficient).	Iron	244-248	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	228-232
12970194-4	2003	A non-lethal mutation of CFD1 (cfd1-1) reduced c-aconitase specific activity in IRP1-transformed yeast by &gt;90%, although IRP1 in these cells could be readily converted to c-aconitase in vitro upon incubation with iron alone.	Iron	216-220	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	25-29
12970194-4	2003	A non-lethal mutation of CFD1 (cfd1-1) reduced c-aconitase specific activity in IRP1-transformed yeast by &gt;90%, although IRP1 in these cells could be readily converted to c-aconitase in vitro upon incubation with iron alone.	Iron	216-220	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	31-37
12783778-1	2003	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing iron, carbon monoxide, and biliverdin.	Iron	88-92	heme oxygenase 1	Homo sapiens	0-16
12783778-1	2003	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing iron, carbon monoxide, and biliverdin.	Iron	88-92	heme oxygenase 1	Homo sapiens	18-22
12949888-0	2003	Localization of the iron transport proteins Mobilferrin and DMT-1 in the duodenum: the surprising role of mucin.	Iron	20-24	doublesex and mab-3 related transcription factor 1	Homo sapiens	60-65
12949888-1	2003	There are two pathways for inorganic iron uptake in the intestine, the ferric pathway, mediated by the key protein mobilferrin, and the ferrous pathway, mediated by DMT-1.	Iron	37-41	doublesex and mab-3 related transcription factor 1	Homo sapiens	165-170
12949888-7	2003	In iron-deficient animals both DMT-1 and Mobilferrin were concentrated in the apical surface of the villae.	Iron	3-7	doublesex and mab-3 related transcription factor 1	Homo sapiens	31-36
12956771-1	2003	The hepatic antimicrobial protein, hepcidin, is implicated in duodenal iron absorption and mobilization.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	35-43
12956771-2	2003	Overexpression of the hepcidin gene is associated with a hypoferraemic, microcytic, iron-refractory anaemia.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	22-30
14614257-3	2003	Both CNPase activity and concentrations in the cerebrum and hindbrain were significantly lower in pre- and postweaning iron-deficient rats.	Iron	119-123	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	5-11
14502650-8	2003	(3) In neurodegeneration with brain iron accumulation type I, or Hallervorden-Spatz disease, alpha-synuclein is present in axonal spheroids and glial and neuronal inclusions.	Iron	36-40	synuclein alpha	Homo sapiens	93-108
6370051-7	1984	Hemoglobin and hematocrit values of the pigs shortly after birth and weekly thereafter revealed that within 2 weeks, both sets of values from the pigs treated with a large dose of Fe were within acceptable laboratory limits and substantially greater than the values obtained for the nontreated pigs, which were severely anemic.	Iron	180-182	HGB	Sus scrofa	0-10
12867346-1	2003	Discoloration and mineralization of Reactive Red HE-3B were studied by using a laponite clay-based Fe nanocomposite (Fe-Lap-RD) as a heterogeneous catalyst in the presence of H2O2 and UV light.	Iron	99-101	LAP	Homo sapiens	120-123
6693498-0	1984	A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation.	Iron	13-17	transferrin	Mus musculus	39-50
6693498-2	1984	Since transferrin is an iron-carrying protein, we asked whether iron is crucial for tubulogenesis.	Iron	24-28	transferrin	Mus musculus	6-17
6693498-2	1984	Since transferrin is an iron-carrying protein, we asked whether iron is crucial for tubulogenesis.	Iron	64-68	transferrin	Mus musculus	6-17
6693498-6	1984	However, iron coupled to the nonphysiological, lipophilic iron chelator, pyridoxal isonicotinoyl hydrazone, to form FePIH, could sustain levels of cell proliferation and tubulogenesis similar to those attained by transferrin.	Iron	9-13	transferrin	Mus musculus	213-224
6693498-7	1984	Thus, the role of transferrin in cell proliferation during tubulogenesis is solely to provide iron.	Iron	94-98	transferrin	Mus musculus	18-29
12888492-5	2003	Introduction of str1+ into a Saccharomyces cerevisiae fet3Delta arn1-4Delta strain led to assimilation of iron from ferrichrome, revealing that Str1 functions as a siderophore-iron transporter in S.pombe.	Iron	106-110	cystathionine gamma-lyase CYS3	Saccharomyces cerevisiae S288C	16-20
6692005-3	1984	If the medium was saturated with iron prior to incubation with the cells, little of the released iron was then bound by transferrin but appeared either as a high molecular weight fraction or, if nitrilotriacetate was present in the medium, some also appeared as a low molecular weight fraction.	Iron	33-37	transferrin	Mus musculus	120-131
6692005-6	1984	Incubation at 0 degrees C completely suppressed the release of degraded transferrin, but iron release continued at about 30% of the rate seen in control cultures at 37 degrees C. A model for the intracellular handling of ingested iron is proposed to take account of the different release patterns of resident and stimulated macrophages.	Iron	230-234	transferrin	Mus musculus	72-83
12888492-5	2003	Introduction of str1+ into a Saccharomyces cerevisiae fet3Delta arn1-4Delta strain led to assimilation of iron from ferrichrome, revealing that Str1 functions as a siderophore-iron transporter in S.pombe.	Iron	106-110	cystathionine gamma-lyase CYS3	Saccharomyces cerevisiae S288C	144-148
12637325-0	2003	Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	14-22
6084237-3	1984	The present results suggest that the DNA breakage mechanism of the Mn-BLM resembles that of the Fe-BLM, and that Mn as well as Fe is an effective metal cofactor in the BLM drug action.	Iron	96-98	BLM RecQ like helicase	Homo sapiens	70-73
6084237-3	1984	The present results suggest that the DNA breakage mechanism of the Mn-BLM resembles that of the Fe-BLM, and that Mn as well as Fe is an effective metal cofactor in the BLM drug action.	Iron	96-98	BLM RecQ like helicase	Homo sapiens	99-102
12637325-1	2003	Experimental data suggest the antimicrobial peptide hepcidin as a central regulator in iron homeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	52-60
6084237-3	1984	The present results suggest that the DNA breakage mechanism of the Mn-BLM resembles that of the Fe-BLM, and that Mn as well as Fe is an effective metal cofactor in the BLM drug action.	Iron	96-98	BLM RecQ like helicase	Homo sapiens	99-102
12637325-2	2003	In this study, we characterized the expression of human hepcidin in experimental and clinical iron overload conditions, including hereditary hemochromatosis.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	56-64
12637325-3	2003	Using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), we determined expression of hepcidin and the most relevant iron-related genes in liver biopsies from patients with hemochromatosis and iron-stain-negative control subjects.	Iron	212-216	hepcidin antimicrobial peptide	Homo sapiens	105-113
12637325-4	2003	Regulation of hepcidin mRNA expression in response to transferrin-bound iron, non-transferrin-bound iron, and deferoxamine was analyzed in HepG2 cells.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	14-22
6639671-5	1983	We investigated the mechanistic basis for such acute reduction and report that iron was not only required as a co-substrate for I-P-450 heme formation, but also as a regulator of two key heme-synthetic enzymes, delta-aminolevulinic acid synthetase and ferrochelatase.	Iron	79-83	ferrochelatase	Homo sapiens	252-266
12637325-4	2003	Regulation of hepcidin mRNA expression in response to transferrin-bound iron, non-transferrin-bound iron, and deferoxamine was analyzed in HepG2 cells.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	14-22
12637325-8	2003	In vitro data indicated that hepcidin expression is down-regulated in response to non-transferrin-bound iron.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	29-37
12637325-10	2003	Although the causality is not yet clear, this interaction might result from a down-regulation of hepcidin expression in response to significant levels of non-transferrin-bound iron.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	97-105
6887257-1	1983	The Fe fragment of a gamma 2b murine monoclonal anti-p-azophenylarsonate antibody (R19.9, IgG2b, kappa) has been crystallized.	Iron	4-6	immunoglobulin heavy constant gamma 2B	Mus musculus	21-29
12801950-1	2003	BACKGROUND AND AIMS: In HFE associated hereditary haemochromatosis, the duodenal enterocyte behaves as if iron deficient and previous reports have shown increased duodenal expression of divalent metal transporter 1 (DMT1) and iron regulated gene 1 (Ireg1) in affected subjects.	Iron	106-110	solute carrier family 11 member 2	Homo sapiens	186-214
6887257-1	1983	The Fe fragment of a gamma 2b murine monoclonal anti-p-azophenylarsonate antibody (R19.9, IgG2b, kappa) has been crystallized.	Iron	4-6	immunoglobulin heavy constant gamma 2B	Mus musculus	90-95
12801950-5	2003	RESULTS: Expression of DMT1 (IRE) and Ireg1 was increased 3-5-fold in iron deficient subjects compared with iron replete subjects.	Iron	70-74	solute carrier family 11 member 2	Homo sapiens	23-27
6602802-1	1983	Induction of ferritin synthesis by iron in liver as well as red cells combines high translational efficiency with increased utilization of preformed ferritin mRNA.	Iron	35-39	Fer2	Triticum aestivum	13-21
12801950-5	2003	RESULTS: Expression of DMT1 (IRE) and Ireg1 was increased 3-5-fold in iron deficient subjects compared with iron replete subjects.	Iron	70-74	solute carrier family 40 member 1	Homo sapiens	38-43
6602802-1	1983	Induction of ferritin synthesis by iron in liver as well as red cells combines high translational efficiency with increased utilization of preformed ferritin mRNA.	Iron	35-39	Fer2	Triticum aestivum	149-157
6602802-2	1983	Control of ferritin synthesis by iron at the level of transcription is potentially hazardous to DNA because of the iron-catalyzed degradation of DNA.	Iron	33-37	Fer2	Triticum aestivum	11-19
6602802-2	1983	Control of ferritin synthesis by iron at the level of transcription is potentially hazardous to DNA because of the iron-catalyzed degradation of DNA.	Iron	115-119	Fer2	Triticum aestivum	11-19
6602802-3	1983	The induction of ferritin synthesis in reticulocytes of embryos (bullfrog tadpoles) occurs by two types of translational control i.e. increased availability of stored ferritin mRNA, in response to iron, coupled with a high translational efficiency.	Iron	197-201	Fer2	Triticum aestivum	17-25
6602802-3	1983	The induction of ferritin synthesis in reticulocytes of embryos (bullfrog tadpoles) occurs by two types of translational control i.e. increased availability of stored ferritin mRNA, in response to iron, coupled with a high translational efficiency.	Iron	197-201	Fer2	Triticum aestivum	167-175
6602802-4	1983	Since erythroid cell nuclei have large amounts of heterochromatin and may be relatively inactive genetically, the translational control of ferritin by iron observed in red cells was studied in other tissue by isolating poly (A+) RNA from tadpole liver and analyzing protein synthesis in vitro.	Iron	151-155	Fer2	Triticum aestivum	139-147
12801950-5	2003	RESULTS: Expression of DMT1 (IRE) and Ireg1 was increased 3-5-fold in iron deficient subjects compared with iron replete subjects.	Iron	108-112	solute carrier family 11 member 2	Homo sapiens	23-27
6602802-8	1983	The results indicate that the increased availability for translation of stored ferritin mRNA, in response to iron, and the high translational efficiency of ferritin mRNA are a general characteristic of ferritin synthesis rather than a specific feature of red cell maturation.	Iron	109-113	Fer2	Triticum aestivum	79-87
6602802-9	1983	This novel form of regulation of ferritin gene expression can be attributed to a need to protect DNA from degradation by iron and oxygen.	Iron	121-125	Fer2	Triticum aestivum	33-41
12801950-5	2003	RESULTS: Expression of DMT1 (IRE) and Ireg1 was increased 3-5-fold in iron deficient subjects compared with iron replete subjects.	Iron	108-112	solute carrier family 40 member 1	Homo sapiens	38-43
12801950-6	2003	Duodenal expression of DMT1 (IRE) and Ireg1 was similar in haemochromatosis patients and iron replete subjects but in haemochromatosis patients with elevated serum ferritin concentrations, both DMT1 (IRE) and Ireg1 expression were inappropriately increased relative to serum ferritin concentration.	Iron	89-93	solute carrier family 11 member 2	Homo sapiens	23-27
12801950-6	2003	Duodenal expression of DMT1 (IRE) and Ireg1 was similar in haemochromatosis patients and iron replete subjects but in haemochromatosis patients with elevated serum ferritin concentrations, both DMT1 (IRE) and Ireg1 expression were inappropriately increased relative to serum ferritin concentration.	Iron	89-93	solute carrier family 40 member 1	Homo sapiens	38-43
18963399-5	1983	For a 12-hr irradiation at a thermal neutron flux of 8 x 10(13) n.cm(-2).sec(-1), the limits of detection for a niobium matrix vary between 0.6 pg (for Mn) and 0.6 mug (for Fe).	Iron	173-175	secretory blood group 1, pseudogene	Homo sapiens	73-79
12801950-9	2003	CONCLUSIONS: These findings are consistent with DMT1 (IRE) and Ireg1 playing primary roles in the adaptive response to iron deficiency.	Iron	119-123	solute carrier family 11 member 2	Homo sapiens	48-52
12801950-9	2003	CONCLUSIONS: These findings are consistent with DMT1 (IRE) and Ireg1 playing primary roles in the adaptive response to iron deficiency.	Iron	119-123	solute carrier family 40 member 1	Homo sapiens	63-68
12857562-0	2003	Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family.	Iron	39-43	solute carrier family 40 member 1	Homo sapiens	104-117
6296362-1	1983	One of the most efficient anions in enhancing the ability of desferrioxamine (DFO) to remove iron from transferrin in vitro has been shown to be pyrophosphate (PYP).	Iron	93-97	transferrin	Mus musculus	103-114
6296362-1	1983	One of the most efficient anions in enhancing the ability of desferrioxamine (DFO) to remove iron from transferrin in vitro has been shown to be pyrophosphate (PYP).	Iron	93-97	pyrophosphatase (inorganic) 1	Mus musculus	160-163
6296362-7	1983	PYP administered alone acted as a weaker chelator of iron than DFO.	Iron	53-57	pyrophosphatase (inorganic) 1	Mus musculus	0-3
6296362-10	1983	That observation would suggest that DFO + PYP combined in a unique treatment, interact with iron through a common reaction pathway and that PYP plays in vivo a synergistic role in that interaction.	Iron	92-96	pyrophosphatase (inorganic) 1	Mus musculus	42-45
12857562-0	2003	Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family.	Iron	39-43	solute carrier family 40 member 1	Homo sapiens	124-131
6296362-11	1983	The kind of iron with which DFO + PYP interacts is then suggested to be the transferrin-bound iron located in extracellular spaces of tissues.	Iron	12-16	pyrophosphatase (inorganic) 1	Mus musculus	34-37
6296362-11	1983	The kind of iron with which DFO + PYP interacts is then suggested to be the transferrin-bound iron located in extracellular spaces of tissues.	Iron	12-16	transferrin	Mus musculus	76-87
12787877-10	2003	Further the increase in the expression of the transporter DMT-1 in HepG2 cells after iron treatment is in contrast to the regulation in the duodenum and may be involved in the upregulated uptake of potentially toxic non-transferrin bound iron from the circulation to store it in the non-toxic form of ferritin.	Iron	85-89	solute carrier family 11 member 2	Homo sapiens	58-63
6296362-11	1983	The kind of iron with which DFO + PYP interacts is then suggested to be the transferrin-bound iron located in extracellular spaces of tissues.	Iron	94-98	pyrophosphatase (inorganic) 1	Mus musculus	34-37
6296362-11	1983	The kind of iron with which DFO + PYP interacts is then suggested to be the transferrin-bound iron located in extracellular spaces of tissues.	Iron	94-98	transferrin	Mus musculus	76-87
12787877-10	2003	Further the increase in the expression of the transporter DMT-1 in HepG2 cells after iron treatment is in contrast to the regulation in the duodenum and may be involved in the upregulated uptake of potentially toxic non-transferrin bound iron from the circulation to store it in the non-toxic form of ferritin.	Iron	238-242	solute carrier family 11 member 2	Homo sapiens	58-63
12622689-1	2003	NO potently up-regulates vascular haem oxygenase-1 (HO-1), an inducible defensive protein that degrades haem to CO, iron and the antioxidant bilirubin.	Iron	116-120	heme oxygenase 1	Homo sapiens	34-50
6837929-15	1983	One of the secreted glycoproteins, uteroferrin, is believed to play an important role in the iron transfer from mother to fetus.	Iron	93-97	acid phosphatase 5, tartrate resistant	Sus scrofa	35-46
12622689-1	2003	NO potently up-regulates vascular haem oxygenase-1 (HO-1), an inducible defensive protein that degrades haem to CO, iron and the antioxidant bilirubin.	Iron	116-120	heme oxygenase 1	Homo sapiens	52-56
6822435-0	1983	Turnover in the transferrin iron pool during the hypoferremic phase of experimental Neisseria meningitidis infection in mice.	Iron	28-32	transferrin	Mus musculus	16-27
12626517-1	2003	Human heme oxygenase-1 (hHO-1) catalyzes the NADPH-cytochrome P450 reductase-dependent oxidation of heme to biliverdin, CO, and free iron.	Iron	133-137	heme oxygenase 1	Homo sapiens	6-22
6822435-1	1983	Mouse transferrin was used to specifically label the plasma transferrin iron pool for studies of iron kinetics in normal mice and infected mice during the hypoferremic phase of experimental meningococcal infection.	Iron	72-76	transferrin	Mus musculus	6-17
6822435-1	1983	Mouse transferrin was used to specifically label the plasma transferrin iron pool for studies of iron kinetics in normal mice and infected mice during the hypoferremic phase of experimental meningococcal infection.	Iron	72-76	transferrin	Mus musculus	60-71
6982898-0	1982	Translational control of ferritin synthesis by iron in embryonic reticulocytes of the bullfrog.	Iron	47-51	Fer2	Triticum aestivum	25-33
6982898-1	1982	The regulation of ferritin synthesis by iron was examined in the reticulocytes of bullfrog tadpoles where the induction was 40- to 50-fold, increasing from 0.17 +/- 0.05% of total protein synthesis ([3H]leucine incorporation in cell suspension) to 7.4 +/- 1.6% following intraperitoneal injection of ferric ammonium citrate.	Iron	40-44	Fer2	Triticum aestivum	18-26
6982898-2	1982	No significant difference was observed between the levels of ferritin mRNA in control or iron-induced cells, determined by translation of isolated mRNA in a wheat germ system, demonstrating that ferritin induction by iron occurs by a post-transcriptional mechanism.	Iron	217-221	Fer2	Triticum aestivum	195-203
6982898-5	1982	The results indicate that iron-modulated changes in the availability of ferritin mRNA for translation, coupled with the high translational efficiency of the ferritin message, can account for the induction of ferritin synthesis by iron in embryonic erythroid cells.	Iron	26-30	Fer2	Triticum aestivum	72-80
6982898-5	1982	The results indicate that iron-modulated changes in the availability of ferritin mRNA for translation, coupled with the high translational efficiency of the ferritin message, can account for the induction of ferritin synthesis by iron in embryonic erythroid cells.	Iron	26-30	Fer2	Triticum aestivum	157-165
12626517-1	2003	Human heme oxygenase-1 (hHO-1) catalyzes the NADPH-cytochrome P450 reductase-dependent oxidation of heme to biliverdin, CO, and free iron.	Iron	133-137	heme oxygenase 1	Homo sapiens	24-29
6982898-5	1982	The results indicate that iron-modulated changes in the availability of ferritin mRNA for translation, coupled with the high translational efficiency of the ferritin message, can account for the induction of ferritin synthesis by iron in embryonic erythroid cells.	Iron	26-30	Fer2	Triticum aestivum	157-165
6982898-5	1982	The results indicate that iron-modulated changes in the availability of ferritin mRNA for translation, coupled with the high translational efficiency of the ferritin message, can account for the induction of ferritin synthesis by iron in embryonic erythroid cells.	Iron	230-234	Fer2	Triticum aestivum	72-80
6982898-5	1982	The results indicate that iron-modulated changes in the availability of ferritin mRNA for translation, coupled with the high translational efficiency of the ferritin message, can account for the induction of ferritin synthesis by iron in embryonic erythroid cells.	Iron	230-234	Fer2	Triticum aestivum	157-165
6982898-5	1982	The results indicate that iron-modulated changes in the availability of ferritin mRNA for translation, coupled with the high translational efficiency of the ferritin message, can account for the induction of ferritin synthesis by iron in embryonic erythroid cells.	Iron	230-234	Fer2	Triticum aestivum	157-165
12711734-5	2003	The possible role of Nramp1-mediated iron transport on SCV maturation was investigated with membrane-permeant iron chelators.	Iron	37-41	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	21-27
7159665-17	1982	Within the fetus Uf is either bound by the liver, probably to supply iron for hematopoiesis, or cleared by the kidney and transported within the urine to the allantoic sac to serve as a temporary iron storage reservoir.	Iron	69-73	acid phosphatase 5, tartrate resistant	Sus scrofa	17-19
12711734-8	2003	These data suggest that Nramp1-mediated deprivation of iron and possibly of other divalent metals in macrophages antagonizes the ability of Salmonella to alter phagosome maturation.	Iron	55-59	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	24-30
7159665-17	1982	Within the fetus Uf is either bound by the liver, probably to supply iron for hematopoiesis, or cleared by the kidney and transported within the urine to the allantoic sac to serve as a temporary iron storage reservoir.	Iron	196-200	acid phosphatase 5, tartrate resistant	Sus scrofa	17-19
12729891-0	2003	Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload.	Iron	127-131	hepcidin antimicrobial peptide 2	Mus musculus	30-46
7150343-0	1982	Adriamycin stimulates only the iron ion-induced, NADPH-dependent microsomal alkane formation.	Iron	31-35	2,4-dienoyl-CoA reductase 1	Homo sapiens	49-54
12729891-9	2003	Overall our data suggest that both HEPC1 and HEPC2 genes are involved in iron metabolism regulation but could exhibit different activities and/or play distinct roles.	Iron	73-77	hepcidin antimicrobial peptide 2	Mus musculus	45-50
12730597-1	2003	The reaction of [Cp*Fe(eta5-P5)] with Cu(I)Cl in solvent mixtures of CH2Cl2/CH3CN leads to the formation of entirely inorganic fullerene-like molecules of the formula [[Cp*Fe(eta5:eta1:eta1:eta1:eta1:eta1-P5)]12[CuCl]10[Cu2Cl3]5[Cu(CH3CN)2]5] (1) possessing 90 inorganic core atoms.	Iron	20-22	secreted phosphoprotein 1	Homo sapiens	180-184
6290505-6	1982	The anti-transferrin receptor antibody we have obtained partially blocks iron uptake from 59Fe-transferrin by a variety of murine cell lines and inhibits the growth of a murine myeloma cell line in vitro.	Iron	73-77	transferrin	Mus musculus	9-20
6290505-6	1982	The anti-transferrin receptor antibody we have obtained partially blocks iron uptake from 59Fe-transferrin by a variety of murine cell lines and inhibits the growth of a murine myeloma cell line in vitro.	Iron	73-77	transferrin	Mus musculus	95-106
12730597-1	2003	The reaction of [Cp*Fe(eta5-P5)] with Cu(I)Cl in solvent mixtures of CH2Cl2/CH3CN leads to the formation of entirely inorganic fullerene-like molecules of the formula [[Cp*Fe(eta5:eta1:eta1:eta1:eta1:eta1-P5)]12[CuCl]10[Cu2Cl3]5[Cu(CH3CN)2]5] (1) possessing 90 inorganic core atoms.	Iron	20-22	secreted phosphoprotein 1	Homo sapiens	185-189
12730597-1	2003	The reaction of [Cp*Fe(eta5-P5)] with Cu(I)Cl in solvent mixtures of CH2Cl2/CH3CN leads to the formation of entirely inorganic fullerene-like molecules of the formula [[Cp*Fe(eta5:eta1:eta1:eta1:eta1:eta1-P5)]12[CuCl]10[Cu2Cl3]5[Cu(CH3CN)2]5] (1) possessing 90 inorganic core atoms.	Iron	20-22	secreted phosphoprotein 1	Homo sapiens	185-189
6288079-1	1982	Rabbit liver aldehyde oxidase (AO), like milk xanthine oxidase (XO) and chicken liver xanthine dehydrogenase (XDH), possesses the following prosthetic groups: FAD, a functional Mo center, and two spectroscopically distinct iron-sulfur centers, one with gav less than 2.0 (termed Fe/S I) and the other with gav greater than 2.0 (termed Fe/S II) in the reduced enzyme.	Iron	223-227	aldehyde oxidase 1	Gallus gallus	13-29
12730597-1	2003	The reaction of [Cp*Fe(eta5-P5)] with Cu(I)Cl in solvent mixtures of CH2Cl2/CH3CN leads to the formation of entirely inorganic fullerene-like molecules of the formula [[Cp*Fe(eta5:eta1:eta1:eta1:eta1:eta1-P5)]12[CuCl]10[Cu2Cl3]5[Cu(CH3CN)2]5] (1) possessing 90 inorganic core atoms.	Iron	20-22	secreted phosphoprotein 1	Homo sapiens	185-189
12730597-1	2003	The reaction of [Cp*Fe(eta5-P5)] with Cu(I)Cl in solvent mixtures of CH2Cl2/CH3CN leads to the formation of entirely inorganic fullerene-like molecules of the formula [[Cp*Fe(eta5:eta1:eta1:eta1:eta1:eta1-P5)]12[CuCl]10[Cu2Cl3]5[Cu(CH3CN)2]5] (1) possessing 90 inorganic core atoms.	Iron	20-22	secreted phosphoprotein 1	Homo sapiens	185-189
7104456-5	1982	The presented results suggest that the microenvironment around the tightly bound spin label in those methemoglobin derivatives that exhibit the mixed-spin state of the heme iron is prone to an abrupt change above a certain ligand-specific temperature.	Iron	47-51	hemoglobin subunit gamma 2	Homo sapiens	101-114
12585963-4	2003	Either N-acetylcysteine, an antioxidant, or deferoxamine, an iron chelator, resulted in a dose-dependent inhibition of HO-1 mRNA and protein induction during glucose deprivation, suggesting a redox- and iron-dependent mechanism.	Iron	203-207	heme oxygenase 1	Homo sapiens	119-123
6284220-9	1982	These results indicate that the level of transferrin receptors may be the major factor which determines the rate of iron uptake during erythroid cell development.	Iron	116-120	transferrin	Mus musculus	41-52
12737947-4	2003	We propose that the liver plays a central role in the maintenance of iron homeostasis by regulating the expression of hepcidin in response to changes in the ratio of diferric transferrin in the circulation to the level of transferrin receptor 1.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	118-126
12737947-6	2003	Circulating hepcidin then directly influences the expression of Ireg1 in the mature villus enterocytes of the duodenum, thereby regulating iron absorption in response to body iron requirements.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	12-20
12737947-6	2003	Circulating hepcidin then directly influences the expression of Ireg1 in the mature villus enterocytes of the duodenum, thereby regulating iron absorption in response to body iron requirements.	Iron	139-143	solute carrier family 40 member 1	Homo sapiens	64-69
12737947-6	2003	Circulating hepcidin then directly influences the expression of Ireg1 in the mature villus enterocytes of the duodenum, thereby regulating iron absorption in response to body iron requirements.	Iron	175-179	hepcidin antimicrobial peptide	Homo sapiens	12-20
12737947-6	2003	Circulating hepcidin then directly influences the expression of Ireg1 in the mature villus enterocytes of the duodenum, thereby regulating iron absorption in response to body iron requirements.	Iron	175-179	solute carrier family 40 member 1	Homo sapiens	64-69
12675844-12	2003	Direct incubation of cisplatin with the microsomes isolated from CYP2e1-/- kidney cortex produced significant decrease in the generation of hydrogen peroxide, catalytic iron content, and hydroxyl radical formation compared to CYP2e1+/+ microsomes.	Iron	169-173	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	65-71
12697826-5	2003	In addition, treatment of cells with the iron chelator desferrioxamine also reduced MLH1 and PMS2 levels, in keeping with low oxygen tension being the stress signal that provokes the altered MMR gene expression.	Iron	41-45	mutL homolog 1	Homo sapiens	84-88
12697826-5	2003	In addition, treatment of cells with the iron chelator desferrioxamine also reduced MLH1 and PMS2 levels, in keeping with low oxygen tension being the stress signal that provokes the altered MMR gene expression.	Iron	41-45	PMS1 homolog 2, mismatch repair system component	Homo sapiens	93-97
12724641-19	2003	Ceruloplasmin may protect the retina from oxidative stress by decreasing the amount of ferrous iron available to produce reactive oxygen species.	Iron	95-99	ceruloplasmin	Homo sapiens	0-13
12480693-1	2003	beta(2)-Microglobulin (beta(2)m) is a chaperone of major histocompatibility complex (MHC) class I (-like) molecules that play a central role in antigen presentation, immunoglobulin transport, and iron metabolism.	Iron	196-200	beta-2-microglobulin	Homo sapiens	0-21
12480693-1	2003	beta(2)-Microglobulin (beta(2)m) is a chaperone of major histocompatibility complex (MHC) class I (-like) molecules that play a central role in antigen presentation, immunoglobulin transport, and iron metabolism.	Iron	196-200	beta-2-microglobulin	Homo sapiens	23-31
12480705-1	2003	A mitochondrial half-type ATP-binding cassette (ABC) protein, ABC7, plays a role in iron homeostasis in mitochondria, and defects in human ABC7 were shown to be responsible for the inherited disease X-linked sideroblastic anemia/ataxia.	Iron	84-88	ATP binding cassette subfamily B member 7	Homo sapiens	62-66
12480705-1	2003	A mitochondrial half-type ATP-binding cassette (ABC) protein, ABC7, plays a role in iron homeostasis in mitochondria, and defects in human ABC7 were shown to be responsible for the inherited disease X-linked sideroblastic anemia/ataxia.	Iron	84-88	ATP binding cassette subfamily B member 7	Homo sapiens	139-143
12656741-2	2003	HFE, the protein defective in hereditary hemochromatosis, and transferrin receptor 2 (TfR2) are two novel protein candidates that could be involved in mechanisms of iron transport across the platelet plasma membrane.	Iron	165-169	transferrin receptor 2	Homo sapiens	62-84
12656741-2	2003	HFE, the protein defective in hereditary hemochromatosis, and transferrin receptor 2 (TfR2) are two novel protein candidates that could be involved in mechanisms of iron transport across the platelet plasma membrane.	Iron	165-169	transferrin receptor 2	Homo sapiens	86-90
12681966-0	2003	Analysis of HFE and TFR2 mutations in selected blood donors with biochemical parameters of iron overload.	Iron	91-95	transferrin receptor 2	Homo sapiens	20-24
12689772-2	2003	Recently, evidence has been gathered to suggest that Abeta precipitation and toxicity in AD are caused by abnormal interactions with neocortical metal ions, especially Zn, Cu and Fe.	Iron	179-181	amyloid beta (A4) precursor protein	Mus musculus	53-58
12689772-4	2003	An inevitable, age-dependent rise in brain Cu and Fe might hypermetallate the Abeta peptide, causing the catalysis of H(2)O(2) production that mediates the toxicity and auto-oxidation of Abeta.	Iron	50-52	amyloid beta (A4) precursor protein	Mus musculus	78-83
12689772-4	2003	An inevitable, age-dependent rise in brain Cu and Fe might hypermetallate the Abeta peptide, causing the catalysis of H(2)O(2) production that mediates the toxicity and auto-oxidation of Abeta.	Iron	50-52	amyloid beta (A4) precursor protein	Mus musculus	187-192
12611510-2	2003	Apomyoglobin was successfully coupled with a stoichiometric amount of ferric hemiporphycene to afford the reconstituted myoglobin equipped with the iron coordination structure of native protein.	Iron	148-152	myoglobin	Homo sapiens	3-12
12572666-6	2003	Heme oxygenase-1, an enzyme that catalyzes the conversion of heme to iron and biliverdin, is increased in Alzheimer disease suggesting increased heme turnover as a source of redox-active iron.	Iron	187-191	heme oxygenase 1	Homo sapiens	0-16
12572674-4	2003	The blue copper plasma protein, ceruloplasmin, and its intracellular homologue, hephaestin, play a role in cellular iron release.	Iron	116-120	ceruloplasmin	Homo sapiens	32-45
12572680-1	2003	Ceruloplasmin, a multi-copper ferroxidase that affects the distribution of tissue iron, has antioxidant effects through the oxidation of ferrous iron to ferric iron.	Iron	82-86	ceruloplasmin	Homo sapiens	0-13
12572681-8	2003	In the current paper we have shown that iron induces an imbalance in the function of Cdk5/p25 system of hippocampal neurons, resulting in a marked decrease in tau phosphorylation at the typical Alzheimer"s epitopes.	Iron	40-44	cyclin dependent kinase 5	Homo sapiens	85-89
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Iron	101-105	heme oxygenase 1	Homo sapiens	0-16
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Iron	101-105	heme oxygenase 1	Homo sapiens	18-22
12753426-0	2003	Effect of iron treatment on nickel absorption and gene expression of the divalent metal transporter (DMT1) by human intestinal Caco-2 cells.	Iron	10-14	solute carrier family 11 member 2	Homo sapiens	101-105
12753426-1	2003	Divalent Metal Transporter 1 (DMT1) is a transmembrane transporter located at the apical membrane of enterocytes and implicated in the duodenal uptake of iron.	Iron	154-158	solute carrier family 11 member 2	Homo sapiens	0-28
12753426-1	2003	Divalent Metal Transporter 1 (DMT1) is a transmembrane transporter located at the apical membrane of enterocytes and implicated in the duodenal uptake of iron.	Iron	154-158	solute carrier family 11 member 2	Homo sapiens	30-34
7074101-3	1982	(3) The extent of the rapid reduction of cytochrome b in the presence of excess antimycin is proportional to the percentage of intact Rieske Fe-S cluster.	Iron	141-145	mitochondrially encoded cytochrome b	Homo sapiens	41-53
12753426-6	2003	Iron treatment resulted in decreased DMT1 gene expression which correlated well with the uptake of 59Fe and 63Ni into fully differentiated Caco-2 cells.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	37-41
12584701-0	2003	Iron twin-coronet porphyrins as models of myoglobin and hemoglobin: amphibious electrostatic effects of overhanging hydroxyl groups for successful CO/O2 discrimination.	Iron	0-4	myoglobin	Homo sapiens	42-51
6277946-0	1982	Function of the iron-sulfur protein of the cytochrome b-c1 segment in electron transfer reactions of the mitochondrial respiratory chain.	Iron	16-20	mitochondrially encoded cytochrome b	Homo sapiens	43-55
6277946-6	1982	The function of the iron-sulfur protein in these oxidation-reduction reactions is consistent with a cyclic pathway of electron transfer through the cytochrome b-c1 complex, in which the iron-sulfur protein functions as a ubiquinol-cytochrome c1/ubisemiquinone-cytochrome b oxidoreductase.	Iron	20-24	mitochondrially encoded cytochrome b	Homo sapiens	148-160
6277946-6	1982	The function of the iron-sulfur protein in these oxidation-reduction reactions is consistent with a cyclic pathway of electron transfer through the cytochrome b-c1 complex, in which the iron-sulfur protein functions as a ubiquinol-cytochrome c1/ubisemiquinone-cytochrome b oxidoreductase.	Iron	20-24	mitochondrially encoded cytochrome b	Homo sapiens	260-272
12527228-2	2003	Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages; (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1; and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms.	Iron	60-64	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	49-56
7056739-0	1982	Iron transfer between the purple phosphatase uteroferrin and transferrin and its possible role in iron metabolism of the fetal pig.	Iron	0-4	acid phosphatase 5, tartrate resistant	Sus scrofa	45-56
7056739-0	1982	Iron transfer between the purple phosphatase uteroferrin and transferrin and its possible role in iron metabolism of the fetal pig.	Iron	98-102	acid phosphatase 5, tartrate resistant	Sus scrofa	45-56
7056739-1	1982	Uteroferrin, a purple-colored, iron-containing phosphatase which is induced by progesterone in the porcine uterus, has been proposed to be an intermediary in iron transfer between the mother and conceptus in the pig.	Iron	31-35	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
7056739-3	1982	When [59Fe]uteroferrin was introduced into the allantoic sacs of five fetuses at Day 60 of pregnancy, its iron was transferred to another protein, identified as transferrin.	Iron	106-110	acid phosphatase 5, tartrate resistant	Sus scrofa	11-22
12498987-5	2003	Disrupted HO-1 expression was associated with decreased lung reactive iron and iron-associated proteins, decreased NADPH cytochrome cp450 reductase activity, and decreased lung peroxidase activity compared to WT.	Iron	70-74	heme oxygenase 1	Homo sapiens	10-14
7056739-4	1982	The half-life of iron loss from uteroferrin was approximately 24 h and the kinetics suggested an approximately second order process.	Iron	17-21	acid phosphatase 5, tartrate resistant	Sus scrofa	32-43
7056739-8	1982	Following loss of its iron to transferrin in allantoic fluid, uteroferrin rapidly loses immunological reactivity and is cleaved proteolytically into small peptides.	Iron	22-26	acid phosphatase 5, tartrate resistant	Sus scrofa	62-73
7056739-9	1982	The transfer of iron between uteroferrin and transferrin has also been followed in vitro.	Iron	16-20	acid phosphatase 5, tartrate resistant	Sus scrofa	29-40
7056739-10	1982	Iron on uteroferrin is relatively stable to pH and is not readily lost to transferrin at around neutral pH unless low molecular iron chelators such as citrate, pyrophosphate, ATP, or ascorbate are present.	Iron	0-4	acid phosphatase 5, tartrate resistant	Sus scrofa	8-19
7056739-10	1982	Iron on uteroferrin is relatively stable to pH and is not readily lost to transferrin at around neutral pH unless low molecular iron chelators such as citrate, pyrophosphate, ATP, or ascorbate are present.	Iron	128-132	acid phosphatase 5, tartrate resistant	Sus scrofa	8-19
7056739-12	1982	Results are consistent with a model in which maternal uteroferrin can transfer its iron to fetal transferrin via a low molecular weight intermediary in the allantoic sac.	Iron	83-87	acid phosphatase 5, tartrate resistant	Sus scrofa	54-65
12498987-5	2003	Disrupted HO-1 expression was associated with decreased lung reactive iron and iron-associated proteins, decreased NADPH cytochrome cp450 reductase activity, and decreased lung peroxidase activity compared to WT.	Iron	79-83	heme oxygenase 1	Homo sapiens	10-14
12498987-7	2003	This suggests that disruption of HO-1 protects against hyperoxia by diminishing the generation of toxic reactive intermediates in the lung via iron and H(2)O(2).	Iron	143-147	heme oxygenase 1	Homo sapiens	33-37
7055660-1	1982	In several mouse tumour models iron given parenterally not only inhibited the transport of 67Ga by plasma transferrin but also accelerated the binding of 67Ga in tumour tissue, particularly during the first hour after 67Ga injection.	Iron	31-35	transferrin	Mus musculus	106-117
12445862-14	2002	Model experiments revealed that the effect is based on a doxorubicin-induced release of iron from transferrin which is enhanced by ascorbate and the subsequent formation of doxorubicin-iron complexes.	Iron	185-189	inhibitor of carbonic anhydrase	Canis lupus familiaris	98-109
12393173-1	2002	Aceruloplasminemia is an autosomal recessive disorder caused by mutations in the ceruloplasmin (CP) gene, and is characterized by a unique combination of neurovisceral iron overload and iron deficiency anemia.	Iron	168-172	ceruloplasmin	Mus musculus	1-14
7198687-6	1982	One of these was a basic protein indistinguishable in electrophoretic properties from the uterine acid phosphatase of the pig, uteroferrin, which is believed to be involved in iron transport from the uterine endometrial epithelium to the conceptus.	Iron	176-180	acid phosphatase 5, tartrate resistant	Sus scrofa	127-138
7147924-0	1982	[Reduced glutathione and porphobilinogen synthase activity in the erythrocytes of anemic patients with low serum iron].	Iron	113-117	aminolevulinate dehydratase	Homo sapiens	25-49
12393173-1	2002	Aceruloplasminemia is an autosomal recessive disorder caused by mutations in the ceruloplasmin (CP) gene, and is characterized by a unique combination of neurovisceral iron overload and iron deficiency anemia.	Iron	168-172	ceruloplasmin	Mus musculus	96-98
6272847-0	1981	Function of the iron-sulfur protein of the cytochrome b-c1 segment in electron-transfer and energy-conserving reactions of the mitochondrial respiratory chain.	Iron	16-20	mitochondrially encoded cytochrome b	Homo sapiens	43-55
12393173-8	2002	This result supports the hypothesis that CP mainly acts to release iron from cells in the liver.	Iron	67-71	ceruloplasmin	Mus musculus	41-43
12461085-0	2002	Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis.	Iron	18-22	lactotransferrin	Mus musculus	80-91
7317289-0	1981	Release of iron by resident and stimulated mouse peritoneal macrophages following ingestion and degradation of transferrin-antitransferrin immune complexes.	Iron	11-15	transferrin	Mus musculus	111-122
12461085-6	2002	Here, we show that modulating the extracellular iron pool in beta2m-KO mice by lactoferrin treatment significantly reduces the burden of M. tuberculosis to numbers comparable to those observed in MHC class I-KO mice.	Iron	48-52	lactotransferrin	Mus musculus	79-90
12480908-5	2002	Expression of tahA cDNA restored high-affinity iron uptake in a deltaatx1 yeast strain and oxygen sensitivity in a deltasod1 deltasod2 yeast strain, showing that tahA is also a functional homologue of ATX1.	Iron	47-51	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	201-205
7332869-3	1981	Excess iron, after saturation of the transferrin iron-binding sites with 55Fe, supplied as Fe-citrate, was efficiently removed by its binding to Amberlite CG-400 anion-exchange resin.	Iron	7-11	transferrin	Mus musculus	37-48
7332869-3	1981	Excess iron, after saturation of the transferrin iron-binding sites with 55Fe, supplied as Fe-citrate, was efficiently removed by its binding to Amberlite CG-400 anion-exchange resin.	Iron	49-53	transferrin	Mus musculus	37-48
12441401-6	2002	This Nramp1-dependent up-regulation of SPI2 was mimicked in vitro by chelation of iron, demonstrating the iron-responsive nature of expression of STM SPI2-associated virulence genes.	Iron	82-86	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	5-11
6795121-0	1981	Enhancement of Neisseria meningitidis infection in mice by addition of iron bound to transferrin.	Iron	71-75	transferrin	Mus musculus	85-96
6795121-2	1981	An intraperitoneal injection of 17.5 mg of transferrin carrying 22.7 micrograms of Fe resulted in 100% mortality from infection, as compared with no mortality for the controls which had received saline.	Iron	83-85	transferrin	Mus musculus	43-54
12441401-6	2002	This Nramp1-dependent up-regulation of SPI2 was mimicked in vitro by chelation of iron, demonstrating the iron-responsive nature of expression of STM SPI2-associated virulence genes.	Iron	106-110	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	5-11
6795121-3	1981	Five milligrams of ferri-transferrin (FeTf), carrying 6.5 micrograms of Fe, stimulated and prolonged bacteremia in the mice.	Iron	38-40	transferrin	Mus musculus	25-36
6795121-9	1981	These findings support the hypothesis that the levels of iron in the circulating transferrin pool of mice determine the course of experimental N. meningitidis infection.	Iron	57-61	transferrin	Mus musculus	81-92
12393428-0	2002	Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	28-36
12393428-6	2002	Hepcidin is a peptide hormone that has been implicated in controlling the release of iron from cells.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	0-8
12200437-4	2002	Protection of Fe/S-containing enzymes from oxidative inactivation was found to be dose-dependent with respect to Hsp60 levels.	Iron	14-16	chaperone ATPase HSP60	Saccharomyces cerevisiae S288C	113-118
6118903-1	1981	Both iron and copper play critical biochemical roles in the post-translational modifications of collagen and elastin.	Iron	5-9	elastin	Homo sapiens	109-116
12200437-5	2002	As these enzymes release their iron ions under oxidative-stress conditions, the intracellular labile iron pool, monitored with calcein, was higher in cells with reduced Hsp60 levels.	Iron	31-35	chaperone ATPase HSP60	Saccharomyces cerevisiae S288C	169-174
12200437-5	2002	As these enzymes release their iron ions under oxidative-stress conditions, the intracellular labile iron pool, monitored with calcein, was higher in cells with reduced Hsp60 levels.	Iron	101-105	chaperone ATPase HSP60	Saccharomyces cerevisiae S288C	169-174
12200437-6	2002	Consistently, the iron chelator deferoxamine protected low Hsp60-expressing cells from both oxidant-induced death and protein oxidation.	Iron	18-22	chaperone ATPase HSP60	Saccharomyces cerevisiae S288C	59-64
7251059-3	1981	Transferrins from both homologous and heterologous species were equally effective, but iron-binding half-molecules of transferrin, and low molecular weight iron chelates produced no enhancement.	Iron	87-91	transferrin	Mus musculus	118-129
7251059-5	1981	Although the major function of transferrin in lymphocyte cultures is probably to supply iron, it may also fulfil other functions.	Iron	88-92	transferrin	Mus musculus	31-42
12200437-7	2002	These results indicate that the role of Hsp60 in oxidative-stress defense is explained by protection of several Fe/S proteins, which prevent the release of iron ions and thereby avert further damage.	Iron	156-160	chaperone ATPase HSP60	Saccharomyces cerevisiae S288C	40-45
7251060-3	1981	Total uptake of transferrin during culture was much lower than that of iron, indicating that cells could remove iron from transferrin.	Iron	112-116	transferrin	Mus musculus	16-27
7251060-3	1981	Total uptake of transferrin during culture was much lower than that of iron, indicating that cells could remove iron from transferrin.	Iron	112-116	transferrin	Mus musculus	122-133
12376346-0	2002	Iron increases expression of iron-export protein MTP1 in lung cells.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	49-53
7453802-3	1980	During the isolation of GHL we found the compound to co-isolate through a number of steps with approximately equimolar copper and about 1/5 molar iron.	Iron	146-150	growth hormone 2	Homo sapiens	24-27
12376346-0	2002	Iron increases expression of iron-export protein MTP1 in lung cells.	Iron	29-33	solute carrier family 40 member 1	Homo sapiens	49-53
12376346-3	2002	We provide evidence for the expression and iron-induced upregulation of the metal transporter protein-1 (MTP1) genes in human and rodent lung cells at both the protein and mRNA levels.	Iron	43-47	solute carrier family 40 member 1	Homo sapiens	76-103
12376346-3	2002	We provide evidence for the expression and iron-induced upregulation of the metal transporter protein-1 (MTP1) genes in human and rodent lung cells at both the protein and mRNA levels.	Iron	43-47	solute carrier family 40 member 1	Homo sapiens	105-109
12376346-4	2002	In human bronchial epithelial cells, a 3.8-fold increase in mRNA level and a 2.4-fold increase in protein level of MTP1 were observed after iron exposure.	Iron	140-144	solute carrier family 40 member 1	Homo sapiens	115-119
6254761-2	1980	Observation of the NMR methyl signal of the iron-bound methionine indicates that a methionine residue is the sixth ligand of heme iron in both ferric and ferrous states, although the environment of this methionine is not similar to that in mitochondrial cytochrome c.	Iron	44-48	sulfur oxidation c-type cytochrome SoxA	Thermus thermophilus HB8	254-266
12376346-5	2002	In freshly isolated human macrophages, as much as an 18-fold increase in the MTP1 protein level was detected after incubation with an iron compound.	Iron	134-138	solute carrier family 40 member 1	Homo sapiens	77-81
12376346-6	2002	The elevation in expression of MTP1 gene was also demonstrated in iron-instilled rat lungs and in hypotransferrinemic mouse lungs.	Iron	66-70	solute carrier family 40 member 1	Homo sapiens	31-35
6159328-2	1980	The infection progressed rapidly but then disappeared in concert with the disappearance of plasma transferrin iron.	Iron	110-114	transferrin	Mus musculus	98-109
6159328-6	1980	A working hypothesis to explain the roles of iron in infection was developed: N. meningitidis obtains iron for growth from the transferrin pool, and iron dextran maintains transferrin iron levels during infection.	Iron	45-49	transferrin	Mus musculus	127-138
12376346-7	2002	This is similar to our previous findings with divalent metal transporter-1 (DMT1), an iron transporter that is required for iron uptake and intracellular iron trafficking.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	46-74
6159328-6	1980	A working hypothesis to explain the roles of iron in infection was developed: N. meningitidis obtains iron for growth from the transferrin pool, and iron dextran maintains transferrin iron levels during infection.	Iron	45-49	transferrin	Mus musculus	172-183
6159328-6	1980	A working hypothesis to explain the roles of iron in infection was developed: N. meningitidis obtains iron for growth from the transferrin pool, and iron dextran maintains transferrin iron levels during infection.	Iron	102-106	transferrin	Mus musculus	127-138
12376346-7	2002	This is similar to our previous findings with divalent metal transporter-1 (DMT1), an iron transporter that is required for iron uptake and intracellular iron trafficking.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	76-80
6159328-6	1980	A working hypothesis to explain the roles of iron in infection was developed: N. meningitidis obtains iron for growth from the transferrin pool, and iron dextran maintains transferrin iron levels during infection.	Iron	102-106	transferrin	Mus musculus	127-138
12376346-7	2002	This is similar to our previous findings with divalent metal transporter-1 (DMT1), an iron transporter that is required for iron uptake and intracellular iron trafficking.	Iron	124-128	solute carrier family 11 member 2	Homo sapiens	46-74
12376346-7	2002	This is similar to our previous findings with divalent metal transporter-1 (DMT1), an iron transporter that is required for iron uptake and intracellular iron trafficking.	Iron	124-128	solute carrier family 11 member 2	Homo sapiens	76-80
12547214-2	2002	The identification of the HFE gene and the apical iron transporter divalent metal transporter-1, DMT-1, provide a direct method to address the mechanisms of iron overload in this disease.	Iron	50-54	solute carrier family 11 member 2	Homo sapiens	97-102
6776904-4	1980	TBPA binding capacity for thyroxine was greatly decreased, probably due to iron overload impairing the liver function.	Iron	75-79	transthyretin	Homo sapiens	0-4
12547214-13	2002	The observed twofold upregulation of the DMT-1 is consistent with the slow but steady increase in body iron stores observed in those presenting with clinical features of hereditary hemochromatosis.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	41-46
12547223-0	2002	Hepcidin, a new iron regulatory peptide.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	0-8
12547223-2	2002	Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role in the control of body iron homeostasis.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	56-64
12547223-3	2002	The subject of this paper is to summarize the advances toward the understanding of function and regulation of hepcidin in iron metabolism and to provide new data on the regulation of hepcidin gene expression by erythropoietin, the major regulator of mammalian erythropoiesis.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	110-118
6243966-11	1980	Although the biological significance of this iron pool is not yet clear, it is likely that it represents a transit iron pool being the proximate iron donor for heme synthesis catalyzed by the enzyme ferrochelatase.	Iron	45-49	ferrochelatase	Homo sapiens	199-213
6243966-11	1980	Although the biological significance of this iron pool is not yet clear, it is likely that it represents a transit iron pool being the proximate iron donor for heme synthesis catalyzed by the enzyme ferrochelatase.	Iron	115-119	ferrochelatase	Homo sapiens	199-213
6243966-11	1980	Although the biological significance of this iron pool is not yet clear, it is likely that it represents a transit iron pool being the proximate iron donor for heme synthesis catalyzed by the enzyme ferrochelatase.	Iron	115-119	ferrochelatase	Homo sapiens	199-213
12547224-7	2002	Ferrous iron uptake is facilitated by a DMT-1 pathway which is shared with manganese.	Iron	0-12	doublesex and mab-3 related transcription factor 1	Homo sapiens	40-45
12547224-8	2002	In the iron deficient gut, large quantities of both mobilferrin and DMT-1 are found in goblet cells and intraluminal mucins suggesting that they are secreted with mucin into the intestinal lumen to bind iron to facilitate uptake by the cells.	Iron	7-11	doublesex and mab-3 related transcription factor 1	Homo sapiens	68-73
12547224-8	2002	In the iron deficient gut, large quantities of both mobilferrin and DMT-1 are found in goblet cells and intraluminal mucins suggesting that they are secreted with mucin into the intestinal lumen to bind iron to facilitate uptake by the cells.	Iron	203-207	doublesex and mab-3 related transcription factor 1	Homo sapiens	68-73
6252740-3	1980	The spectroscopic data show that the adsorption of MetHb to imidazole-containing matrices occurs by complex formation between matrix-bound imidazole and the iron of the prosthetic group, with all 4 polypeptide chains of the MetHb molecule being included in the interaction.	Iron	157-161	hemoglobin subunit gamma 2	Homo sapiens	51-56
12546417-2	2002	ERG25p contains three histidine clusters common to nonheme iron binding enzymes and endoplasmic reticulum retrieval signal.	Iron	59-63	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	0-6
12296849-2	2002	Lactoferrin, an iron binding protein, provides a natural feedback mechanism to control the development of such metabolic imbalance and protects against deleterious effects of endotoxin.	Iron	16-20	lactotransferrin	Mus musculus	0-11
539789-1	1979	Serum oxidant activity (AOA) was correlated with the serum caeruloplasmin and serum copper concentration and with the total and available serum iron-binding capacity in 313 normal and abnormal subjects.	Iron	144-148	aprataxin	Homo sapiens	24-27
539789-3	1979	A statistically significant direct correlation between serum AOA and the available iron-binding capacity of serum was found only in normal subjects and in children with thalassemia major and iron overload.	Iron	83-87	aprataxin	Homo sapiens	61-64
539789-3	1979	A statistically significant direct correlation between serum AOA and the available iron-binding capacity of serum was found only in normal subjects and in children with thalassemia major and iron overload.	Iron	191-195	aprataxin	Homo sapiens	61-64
224062-14	1979	The purified protein contains 56 nmol of nonheme iron and 36 nmol of acid-labile sulfide/mg of protein and possesses an EPR spectrum with the characteristic "g = 1.90" signal identical to that of the iron-sulfur protein of the cytochrome b .	Iron	200-204	cytochrome b	Bos taurus	227-239
468828-2	1979	Laser excitation within the visible absorption band of uteroferrin results in an intense resonance Raman spectrum which bears a striking resemblance to that reported for Fe(III)-transferrin, the iron transport protein of serum.	Iron	195-199	acid phosphatase 5, tartrate resistant	Sus scrofa	55-66
90671-4	1979	Substitution of Fe++ for Fe+++ abolished dye binding by elastin.	Iron	16-20	elastin	Homo sapiens	56-63
90671-4	1979	Substitution of Fe++ for Fe+++ abolished dye binding by elastin.	Iron	25-30	elastin	Homo sapiens	56-63
448060-3	1979	The ability of transferrin to deliver iron to ascites tumor cells was confirmed by kinetic studies of transferrin labeled with 59Fe and 125I.	Iron	38-42	transferrin	Mus musculus	15-26
448060-3	1979	The ability of transferrin to deliver iron to ascites tumor cells was confirmed by kinetic studies of transferrin labeled with 59Fe and 125I.	Iron	38-42	transferrin	Mus musculus	102-113
448060-4	1979	These preliminary results are consistent with release of transferrin iron at the cell surface and demonstrate additional uses for ferrocyanide in ultrastructural cytochemical techniques.	Iron	69-73	transferrin	Mus musculus	57-68
682025-2	1978	The study arose out of previously reported tissue-culture work showing marked transferrin stimulation of Ga-67 and Fe-59 uptakes by cultured cells from mouse lymphoid tumors.	Iron	115-117	transferrin	Mus musculus	78-89
647005-3	1978	Plasma membranes prepared by pre-incumbation of mouse reticulocytes with 125I, 59Fe-labeled murine transferrin were able to release 59Fe in preference to 125I when incubated in the presence of murine reticulocyte cytosol, demonstrating that the latter mobilized iron which had been dissociated from transferrin.	Iron	262-266	transferrin	Mus musculus	99-110
638088-0	1978	Transferrin-bound iron and its effect on erythropoietin as measured by mouse fetal liver cell assay.	Iron	18-22	transferrin	Mus musculus	0-11
26360-2	1978	In Wistar rats and humans the results indicate that the daily iron loss under ASA is significantly higher (almost by the factor 2) than that under benorilate.	Iron	62-66	transcription termination factor 2	Homo sapiens	121-129
915001-1	1977	The activity of heme synthetase, which catalyzes the chelation of ferrous iron to protoporphyrin to form heme, is deficient in sonicates of skin fibroblasts cultured from patients with protoporphyria.	Iron	66-78	ferrochelatase	Homo sapiens	16-31
323058-0	1977	Protein d, an iron-transport protein induced by filtration of cultures of Escherichia coli.	Iron	14-18	protein D	Escherichia coli	0-9
186306-0	1976	On the interaction of some catechol derivatives with the iron atom of soybean lipoxygenase.	Iron	57-61	linoleate 9S-lipoxygenase-4	Glycine max	78-90
236028-8	1975	In addition, the preparation contains four distinct types of iron-sulfur centers: S1 and S2 (Em7.4 equals minus 260 mV and 0 mV), and two iron-sulfur proteins which are associated with the cytochrome b-c1 complex: Rieske"s iron-sulfur protein (Em7.4 equals +280 mV) and Ohniski"s Center 5 (Em7.4 equals +35 mV).	Iron	138-142	mitochondrially encoded cytochrome b	Homo sapiens	189-201
236028-8	1975	In addition, the preparation contains four distinct types of iron-sulfur centers: S1 and S2 (Em7.4 equals minus 260 mV and 0 mV), and two iron-sulfur proteins which are associated with the cytochrome b-c1 complex: Rieske"s iron-sulfur protein (Em7.4 equals +280 mV) and Ohniski"s Center 5 (Em7.4 equals +35 mV).	Iron	138-142	mitochondrially encoded cytochrome b	Homo sapiens	189-201
4374554-0	1974	Relaxation spectra of the iron spin transition in methemoglobin.	Iron	26-30	hemoglobin subunit gamma 2	Homo sapiens	50-63
4373719-5	1974	Cytochrome b(5) is the direct electron donor to the desaturase, which appears to utilize the iron in the oxidation-reduction sequence during desaturation of stearyl coenzyme A.	Iron	93-97	mitochondrially encoded cytochrome b	Homo sapiens	0-12
4859401-6	1974	A significant portion of the iron released to the medium is bound to transferrin.	Iron	29-33	transferrin	Mus musculus	69-80
5077746-0	1972	ABO incompatibility and its effects on body iron contents.	Iron	44-48	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	0-3
5003688-0	1971	Effects of certain iron-chelators and antibiotics on the interaction of succinate dehydrogenase and cytochrome b in ubiquinone-depleted submitochondrial particles.	Iron	19-23	mitochondrially encoded cytochrome b	Homo sapiens	100-112
5431821-0	1970	[Effect of the concentration of iron and pyridoxal phosphate on the ferrochelatase activity of erythrocytes].	Iron	32-36	ferrochelatase	Homo sapiens	68-82
5943571-0	1966	A beef-heart cytochrome B dependent on nonheme iron for its reduction.	Iron	47-51	mitochondrially encoded cytochrome b	Homo sapiens	13-25
33662150-0	2021	Nanog is a promising chemo-resistant stemness marker and therapeutic target by iron chelators for esophageal cancer.	Iron	79-83	Nanog homeobox	Homo sapiens	0-5
12455693-8	2002	Fox1 is most highly related to the mammalian homologues hephaestin and ceruloplasmin; its occurrence and pattern of expression in Chlamydomonas indicate, for the first time, a role for copper in iron assimilation in a photosynthetic species.	Iron	195-199	ceruloplasmin	Homo sapiens	71-84
33839281-8	2021	Mice fed iron-deficient HCD had lower liver weights, lower transferrin saturation and decreased ferroportin and hepcidin gene expression than HCD-fed mice.	Iron	9-13	transferrin	Mus musculus	59-70
33839281-8	2021	Mice fed iron-deficient HCD had lower liver weights, lower transferrin saturation and decreased ferroportin and hepcidin gene expression than HCD-fed mice.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	112-120
12382200-8	2002	Homozygous defects in a recently identified gene encoding transferrin receptor 2 lead to iron overload (hemochromatosis type 3) with symptoms similar to those seen in patients with HFE-associated hereditary hemochromatosis (hemochromatosis type 1).	Iron	89-93	transferrin receptor 2	Homo sapiens	58-80
34050997-2	2021	Here, electric-field manipulation of the amplitude and phase of propagating spin waves in a ferromagnetic Fe film on top of a ferroelectric BaTiO3 substrate is demonstrated experimentally.	Iron	106-108	spindlin 1	Homo sapiens	76-80
12382200-10	2002	Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels.	Iron	35-39	solute carrier family 40 member 1	Homo sapiens	50-63
12382200-10	2002	Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	50-63
12382200-10	2002	Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	50-63
34057037-0	2021	Specific expression of AtIRT1 in phloem companion cells suggests its role in iron translocation in aboveground plant organs.	Iron	77-81	iron-regulated transporter 1	Arabidopsis thaliana	23-29
12382200-10	2002	Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	50-63
34057037-1	2021	IRON-REGULATED TRANSPORTER 1 (IRT1) is a central iron transporter responsible for the uptake of iron from the rhizosphere to root epidermal cells.	Iron	0-4	iron-regulated transporter 1	Arabidopsis thaliana	30-34
34057037-1	2021	IRON-REGULATED TRANSPORTER 1 (IRT1) is a central iron transporter responsible for the uptake of iron from the rhizosphere to root epidermal cells.	Iron	49-53	iron-regulated transporter 1	Arabidopsis thaliana	30-34
12382200-12	2002	Heme oxygenase 1 is essential for the catabolism of heme and in the recycling of hemoglobin iron in macrophages.	Iron	92-96	heme oxygenase 1	Homo sapiens	0-16
34057037-1	2021	IRON-REGULATED TRANSPORTER 1 (IRT1) is a central iron transporter responsible for the uptake of iron from the rhizosphere to root epidermal cells.	Iron	96-100	iron-regulated transporter 1	Arabidopsis thaliana	30-34
12382203-6	2002	Characterization of this disorder reveals an essential role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and provides new insights into the mechanisms of human iron metabolism.	Iron	105-109	ceruloplasmin	Homo sapiens	64-77
34058232-3	2021	The aim of this study was to examine the protective effects and latent mechanisms of SAA on retinal iron overload.	Iron	100-104	serum amyloid A1 cluster	Homo sapiens	85-88
34058232-4	2021	SAA reduced iron in the serum and retina, attenuated pathophysiological changes, and reduced retinal iron deposition in the retinas of iron-overloaded mice.	Iron	12-16	serum amyloid A cluster	Mus musculus	0-3
12382203-6	2002	Characterization of this disorder reveals an essential role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and provides new insights into the mechanisms of human iron metabolism.	Iron	145-149	ceruloplasmin	Homo sapiens	64-77
34058232-4	2021	SAA reduced iron in the serum and retina, attenuated pathophysiological changes, and reduced retinal iron deposition in the retinas of iron-overloaded mice.	Iron	101-105	serum amyloid A cluster	Mus musculus	0-3
34058232-4	2021	SAA reduced iron in the serum and retina, attenuated pathophysiological changes, and reduced retinal iron deposition in the retinas of iron-overloaded mice.	Iron	101-105	serum amyloid A cluster	Mus musculus	0-3
12382203-6	2002	Characterization of this disorder reveals an essential role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and provides new insights into the mechanisms of human iron metabolism.	Iron	145-149	ceruloplasmin	Homo sapiens	64-77
34058232-7	2021	The ability of SAA to inhibit apoptosis, increase nuclear Nrf2 expression, and decrease nuclear NF-kappaB expression was further confirmed in the retinas of iron-overloaded mice.	Iron	157-161	serum amyloid A cluster	Mus musculus	15-18
12209011-1	2002	Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	0-28
34058232-8	2021	This study demonstrates that SAA shows significant protective effects against retinal iron overload; its mechanisms might be associated with iron chelation; regulation of iron-handling proteins; and inhibition of oxidative stress, inflammation and apoptosis.	Iron	86-90	serum amyloid A cluster	Mus musculus	29-32
34058232-8	2021	This study demonstrates that SAA shows significant protective effects against retinal iron overload; its mechanisms might be associated with iron chelation; regulation of iron-handling proteins; and inhibition of oxidative stress, inflammation and apoptosis.	Iron	141-145	serum amyloid A cluster	Mus musculus	29-32
34058232-8	2021	This study demonstrates that SAA shows significant protective effects against retinal iron overload; its mechanisms might be associated with iron chelation; regulation of iron-handling proteins; and inhibition of oxidative stress, inflammation and apoptosis.	Iron	141-145	serum amyloid A cluster	Mus musculus	29-32
12209011-1	2002	Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	30-34
34043842-0	2021	High-Spin Iron(VI), Low-Spin Ruthenium(VI), and Magnetically Bistable Osmium(VI) in Molecular Group 8 Nitrido Trifluorides NMF3.	Iron	10-14	spindlin 1	Homo sapiens	5-9
12209011-1	2002	Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor.	Iron	109-113	solute carrier family 11 member 2	Homo sapiens	0-28
12209011-1	2002	Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor.	Iron	109-113	solute carrier family 11 member 2	Homo sapiens	30-34
12209011-3	2002	DMT1 mRNA levels are increased in the duodenum of iron-deficient animals.	Iron	50-54	solute carrier family 11 member 2	Homo sapiens	0-4
12209011-5	2002	Here, we show that iron regulation of DMT1 involves the expression of a previously unrecognized upstream 5" exon (exon 1A) of the human and murine DMT1 gene.	Iron	19-23	solute carrier family 11 member 2	Homo sapiens	38-42
12209011-9	2002	We show that two regulatory regions, the 5" promoter/exon 1A region and the IRE-containing terminal exon participate in iron regulation of DMT1 expression, which operate in a tissue-specific way.	Iron	120-124	solute carrier family 11 member 2	Homo sapiens	139-143
33784507-9	2021	Therefore, our present study suggested that NCOA4-mediated ferritinophagy promoted the level of labile iron pool, leading to enhanced iron availability and elevated cell proliferation of DPSCs.	Iron	103-107	nuclear receptor coactivator 4	Homo sapiens	44-49
12209011-10	2002	These results uncover an unexpected complexity of DMT1 expression and regulation, with implications for understanding the physiology, cell biology, and pathophysiology of mammalian iron metabolism.	Iron	181-185	solute carrier family 11 member 2	Homo sapiens	50-54
33784507-9	2021	Therefore, our present study suggested that NCOA4-mediated ferritinophagy promoted the level of labile iron pool, leading to enhanced iron availability and elevated cell proliferation of DPSCs.	Iron	134-138	nuclear receptor coactivator 4	Homo sapiens	44-49
12230555-0	2002	The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.	Iron	103-107	melanotransferrin	Homo sapiens	62-79
34019669-6	2021	This phenotype is very similar to that observed in mutants of POL3 (encoding the catalytic subunit of Pol delta) that weaken binding of the iron-sulfur cluster.	Iron	140-144	DNA-directed DNA polymerase delta POL3	Saccharomyces cerevisiae S288C	62-66
34019669-8	2021	Further support for the conclusion that met18 strains result in impaired DNA synthesis by Pol delta are the observations that Pol delta isolated from met18 strains has less bound iron and is less processive in vitro than the wild-type holoenzyme.	Iron	179-183	Met18p	Saccharomyces cerevisiae S288C	40-45
12358761-8	2002	These results indicate that iron might play a role in the aggregation of PHFtau leading to the formation of NFTs in AD brain.	Iron	28-32	microtubule associated protein tau	Homo sapiens	73-79
34019669-8	2021	Further support for the conclusion that met18 strains result in impaired DNA synthesis by Pol delta are the observations that Pol delta isolated from met18 strains has less bound iron and is less processive in vitro than the wild-type holoenzyme.	Iron	179-183	Met18p	Saccharomyces cerevisiae S288C	150-155
12136141-7	2002	The binding constants and the electron-transfer rates between cytochrome b(5) and cytochrome c decrease owing to the mutation, which can be accounted for by molecular modeling: the inter-iron distances increase in order to eliminate the unreasonably close contacts resulting from the large volumes of the mutated side chains.	Iron	187-191	cytochrome b5 type A	Homo sapiens	62-77
33975955-3	2021	Here, we show for a Bi-substituted lutetium iron garnet how a suite of advanced electron microscopy techniques, combined with theoretical calculations, can be used to determine the interactions between a range of quantum-order parameters, including lattice, charge, spin, orbital, and crystal field splitting energy.	Iron	44-48	spindlin 1	Homo sapiens	266-270
33956446-2	2021	In the presence of Mo ions, we find that varying the oxidation state of the iron precursor from Fe(II) to Fe(III) causes a progressive loss of atomic long-range order with the stabilization of 2-4 nm particles for the sample prepared with Fe(III).	Iron	76-80	general transcription factor IIE subunit 1	Homo sapiens	96-98
33956446-2	2021	In the presence of Mo ions, we find that varying the oxidation state of the iron precursor from Fe(II) to Fe(III) causes a progressive loss of atomic long-range order with the stabilization of 2-4 nm particles for the sample prepared with Fe(III).	Iron	76-80	general transcription factor IIE subunit 1	Homo sapiens	106-108
12230868-3	2002	HO-1 is a cytoprotective enzyme that degrades heme, a potent oxidant, to generate carbon monoxide, biliverdin (subsequently reduced to bilirubin), and iron.	Iron	151-155	heme oxygenase 1	Homo sapiens	0-4
33938744-0	2021	A Distinct Spin Structure and Giant Baromagnetic Effect in MnNiGe Compounds with Fe-Doping.	Iron	81-83	spindlin 1	Homo sapiens	11-15
33938744-3	2021	Here, we report a new spin structure(CyS-AFMb) with antiferromagnetic(AFM) nature in Fe-doped Mn0.87Fe0.13NiGe.	Iron	85-87	spindlin 1	Homo sapiens	22-26
12130502-0	2002	c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide.	Iron	92-96	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
33938744-8	2021	The compressed lattice by pressure favors the 45 -CoS-FMa and significantly broadened 3d bandwidth of Mn(Fe) atoms, which leads to the shortened magnetic moment and evolution of spin structure.	Iron	105-107	spindlin 1	Homo sapiens	178-182
12130502-6	2002	Iron plays a role in malignant cell growth, local invasion, and tumor progression, possibly due to changes in the expression of the proto-oncogene, c-myc.	Iron	0-4	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	132-153
33991530-0	2021	The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload.	Iron	116-120	hepcidin antimicrobial peptide	Mus musculus	11-19
33991530-1	2021	The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling.	Iron	48-52	hepcidin antimicrobial peptide	Mus musculus	4-12
12130502-11	2002	Ceramide prevented both the iron-induced increases in HSFC proliferation and c-myc expression.	Iron	28-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	77-82
33991530-1	2021	The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	4-12
33991530-1	2021	The hepcidin/ferroportin axis controls systemic iron homeostasis by regulating iron acquisition from the duodenum and reticuloendothelial system, respective sites of iron absorption and recycling.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	4-12
33991530-3	2021	However, it remains unknown whether endogenous hepcidin regulates ferroportin-mediated iron reabsorption under physiological conditions, and whether such regulation is important for kidney and/or systemic iron homeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	47-55
12130502-12	2002	These results indicate that iron probably plays a role in the proliferative changes observed in hemophilic joint disease and that aberrant expression of c-myc may underlie the iron effects.	Iron	176-180	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	153-158
33991530-8	2021	Thus, our study demonstrates that endogenous hepcidin controls ferroportin-mediated tubular iron reabsorption under physiological conditions.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	45-53
12130528-4	2002	The goal of this study was to perform a mutational analysis of the TfR2 and HFE genes in a cohort of non-C282Y iron overload patients of mixed ethnic backgrounds.	Iron	111-115	transferrin receptor 2	Homo sapiens	67-71
12139757-0	2002	Erythroid 5-aminolevulinate synthase, ferrochelatase and DMT1 expression in erythroid progenitors: differential pathways for erythropoietin and iron-dependent regulation.	Iron	144-148	solute carrier family 11 member 2	Homo sapiens	57-61
33980305-11	2021	Prussian blue staining and TEM showed a large amount of iron particles in MTMSCs-PEG3-FTH1 but a minimal amount in MSCs-PEG3-FTH1.	Iron	56-60	ferritin heavy polypeptide 1	Mus musculus	86-90
12434091-0	2002	[Hepcidin: the Grail of iron metabolism].	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	1-9
33975503-3	2021	Interactions between the iron regulatory peptide hormone, hepcidin and the iron exporter ferroportin plays major role in regulating the iron metabolism.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	58-66
33975503-3	2021	Interactions between the iron regulatory peptide hormone, hepcidin and the iron exporter ferroportin plays major role in regulating the iron metabolism.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	58-66
33975503-3	2021	Interactions between the iron regulatory peptide hormone, hepcidin and the iron exporter ferroportin plays major role in regulating the iron metabolism.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	58-66
33975503-7	2021	These compounds act as hepcidin mimetic and inhibits the ferroportin thereby preventing iron overload.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	23-31
12186668-0	2002	A review of the MAFF Optimal Nutrition Status research programme: folate, iron and copper.	Iron	74-78	MAF bZIP transcription factor F	Homo sapiens	16-20
34018804-3	2021	As expected for coherent spin pumping, we observe that the sign of the inverse spin-Hall voltage provides direct information about the mode handedness as deduced by comparing hematite, chromium oxide and the ferrimagnet yttrium-iron garnet.	Iron	228-232	spindlin 1	Homo sapiens	79-83
33956081-0	2021	Corrigendum to: Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signaling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.	Iron	116-120	MAP kinase kinase 5	Arabidopsis thaliana	16-57
12127992-2	2002	Here, we provide direct evidence demonstrating that DMT1 expressed in yeast mutants defective for high affinity iron transport facilitates the transport of iron with an "apparent K(m)" of approximately 1.2 microM, and transport of lead with an "apparent K(m)" of approximately 1.8 microM.	Iron	112-116	solute carrier family 11 member 2	Homo sapiens	52-56
33956081-0	2021	Corrigendum to: Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signaling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.	Iron	116-120	MAP kinase kinase 5	Arabidopsis thaliana	59-63
12127992-2	2002	Here, we provide direct evidence demonstrating that DMT1 expressed in yeast mutants defective for high affinity iron transport facilitates the transport of iron with an "apparent K(m)" of approximately 1.2 microM, and transport of lead with an "apparent K(m)" of approximately 1.8 microM.	Iron	156-160	solute carrier family 11 member 2	Homo sapiens	52-56
12130989-16	2002	Acute samples demonstrated a significant relationship between iron-oxidizing antioxidant protection and both disease severity (r =.30; p =.012) and plasma ceruloplasmin levels (r =.48; p =.00067).	Iron	62-66	ceruloplasmin	Homo sapiens	155-168
33601146-12	2021	Fibroblast growth factor 23, angiogenesis, and antioxidant capability are also involved in the osteoprotective effects of iron chelators.	Iron	122-126	fibroblast growth factor 23	Homo sapiens	0-27
33471309-8	2021	PM2-10 profiles for roadside and train sites were rather comparable and only distinguishable when evaluating the fine (2-2.5 mum) and coarse (2.5-10 mum) PM fractions separately, which enabled the identification of a larger contribution of combustion-derived particles (small, circular, Fe-enriched) at the roadside compared to the train.	Iron	287-289	NODAL modulator 2	Homo sapiens	0-6
12225391-10	2002	CONCLUSION: Iron deficiency anaemia in young women might have been the evolutionary disadvantage causing the gene shift from GPIa-807CC to 807CT.	Iron	12-16	multimerin 1	Homo sapiens	125-129
33683629-4	2021	The active components of Epimedium, Astragalus and Radix Puerariae could effectively up-regulate the expression of HAMP, alleviate the iron overload in the brain tissues of mice, significantly improve the learning and memory ability of AD, down-regulate the expression of Abeta and reduce the deposition of SP in an APPswe/PS1DeltaE9 transgenic mouse model of AD.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	115-119
33683629-10	2021	The present study indicated the effects of the active components of Epimedium, Astragalus and Radix Puerariae may alleviate AD by up-regulating the expression of HAMP, thus reducing brain iron overload, promoting the expression of ADAM10 and ADAM17, inhibiting the expression of BACE1, and reducing the deposition of Abeta.	Iron	188-192	hepcidin antimicrobial peptide	Mus musculus	162-166
12044538-1	2002	Aceruloplasminemia is an autosomal recessive disease of iron overload associated with mutation(s) in the ceruloplasmin gene.	Iron	56-60	ceruloplasmin	Homo sapiens	1-14
33903951-6	2021	In multivariable analysis, total FGF23 remained inversely associated with hemoglobin SDS, independent of eGFR, iron parameters, EPO, and inflammatory markers, suggesting a novel FGF23-hemoglobin association in pediatric kidney transplant patients.	Iron	111-115	fibroblast growth factor 23	Homo sapiens	33-38
12545754-4	2002	It suggested that adequate iron can improve the level of serum thyroid hormone, induce the UCP3 mRNA expression in muscle and mobilize fat to produce heat, but had no effect on UCP2 mRNA in white fat of obese rat.	Iron	27-31	uncoupling protein 3	Rattus norvegicus	91-95
33922251-5	2021	In terms of exogenous stress conditions, GCN5 is also involved in the responses to heat stress, cold stress, and nutrient element deficiency by regulating the related gene expression to maintain the homeostasis of some key metabolites (e.g., cellulose) or ions (e.g., phosphate, iron); in addition, GCN5 is involved in the phytohormone pathways such as ethylene, auxin, and salicylic acid to play various roles during the plant lifecycle.	Iron	279-283	general control non-repressible 5	Arabidopsis thaliana	41-45
12008095-2	2002	Hephaestin is suggested to transport iron from intestinal enterocytes into the circulation.	Iron	37-41	hephaestin	Rattus norvegicus	0-10
34022688-4	2021	Exome sequencing revealed a homozygous pathogenic missense variant (c.187G>C;p.Ala63Pro) of the C19ORF12-gene while iron deposits were absent on repeat MR-imaging of the brain, thus showing that peripheral neuropathy and optic neuropathy can be the sole manifestations of the C19ORF12-related disease spectrum whereby iron accumulation in the brain may be absent.	Iron	116-120	chromosome 19 open reading frame 12	Homo sapiens	96-104
34022688-4	2021	Exome sequencing revealed a homozygous pathogenic missense variant (c.187G>C;p.Ala63Pro) of the C19ORF12-gene while iron deposits were absent on repeat MR-imaging of the brain, thus showing that peripheral neuropathy and optic neuropathy can be the sole manifestations of the C19ORF12-related disease spectrum whereby iron accumulation in the brain may be absent.	Iron	318-322	chromosome 19 open reading frame 12	Homo sapiens	96-104
12008095-5	2002	Therefore, it is suggested that in dietary iron-deficiency, hephaestin gene expression in proximal small intestine is up-regulated to absorb more iron from diet.	Iron	43-47	hephaestin	Rattus norvegicus	60-70
11832486-4	2002	The treatment of the cells with an iron chelator, desferrioxamine, resulted in the induction of apoptosis with a concomitant accumulation of PLAGL2 in the nucleus.	Iron	35-39	pleiomorphic adenoma gene-like 2	Mus musculus	141-147
33866371-0	2021	CORRECTION: IRT1, an arabidopsis transporter essential for iron uptake from the soil and for plant growth.	Iron	59-63	iron-regulated transporter 1	Arabidopsis thaliana	12-16
33610598-8	2021	Heparin-iron was also found to cause a reduction on hepcidin expression through BMP/SMAD and JAK/STAT3 pathways in LPS induced acute inflammation model in mice.	Iron	8-12	hepcidin antimicrobial peptide	Mus musculus	52-60
33610598-9	2021	In ACD mice, heparin-iron could lower elevated serum hepcidin and improve anemia.	Iron	21-25	hepcidin antimicrobial peptide	Mus musculus	53-61
33610598-10	2021	These findings demonstrated low anticoagulant heparin-iron has potential applications for the treatment of ACD with high hepcidin levels.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	121-129
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	179-183	solute carrier family 11 member 2	Homo sapiens	16-66
33388585-2	2021	In this study, iron (Fe), manganese (Mn) co-doped three-dimensional (3D) Ni3S2 nanoflowers were in situ assembled by many inter-connected 2D nanosheets on nickel foam (NF) via hydrothermal and sulfuration treatment.	Iron	15-19	general transcription factor IIE subunit 1	Homo sapiens	21-23
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	179-183	solute carrier family 11 member 2	Homo sapiens	68-74
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	179-183	solute carrier family 11 member 2	Homo sapiens	88-116
33912028-5	2020	Mechanistically, we demonstrated that DOX impedes the stability of the iron-sulfur cluster biogenesis protein Frataxin (FXN) (0.5 fold), resulting in enhanced mitochondrial free iron accumulation (2.5 fold) and reduced aconitase activity (0.4 fold).	Iron	71-75	frataxin	Mus musculus	110-118
33912028-5	2020	Mechanistically, we demonstrated that DOX impedes the stability of the iron-sulfur cluster biogenesis protein Frataxin (FXN) (0.5 fold), resulting in enhanced mitochondrial free iron accumulation (2.5 fold) and reduced aconitase activity (0.4 fold).	Iron	71-75	frataxin	Mus musculus	120-123
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	179-183	solute carrier family 11 member 2	Homo sapiens	118-122
33912028-5	2020	Mechanistically, we demonstrated that DOX impedes the stability of the iron-sulfur cluster biogenesis protein Frataxin (FXN) (0.5 fold), resulting in enhanced mitochondrial free iron accumulation (2.5 fold) and reduced aconitase activity (0.4 fold).	Iron	178-182	frataxin	Mus musculus	110-118
33912028-5	2020	Mechanistically, we demonstrated that DOX impedes the stability of the iron-sulfur cluster biogenesis protein Frataxin (FXN) (0.5 fold), resulting in enhanced mitochondrial free iron accumulation (2.5 fold) and reduced aconitase activity (0.4 fold).	Iron	178-182	frataxin	Mus musculus	120-123
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	179-183	solute carrier family 11 member 2	Homo sapiens	128-157
33898503-3	2021	This study aimed to analyze the application of iron (Fe) and folic acid (FA) bovine serum albumin-nanoparticles (BSA-NPs) as anti-anemic pharmacological agents that fortify stirred functional yogurt (SFY), comparing these with a plain control and SFY fortified with Fe and FA in free forms.	Iron	266-268	albumin	Rattus norvegicus	84-97
33898503-9	2021	Bovine serum albumin-nanoparticles (BSA-NPs) of iron (Fe) and folic acid (FA) can be recommended as anti-anemia supplements in different functional food applications.	Iron	48-52	albumin	Rattus norvegicus	7-20
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	179-183	solute carrier family 11 member 2	Homo sapiens	159-163
33898503-9	2021	Bovine serum albumin-nanoparticles (BSA-NPs) of iron (Fe) and folic acid (FA) can be recommended as anti-anemia supplements in different functional food applications.	Iron	54-56	albumin	Rattus norvegicus	7-20
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	279-283	solute carrier family 11 member 2	Homo sapiens	16-66
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	279-283	solute carrier family 11 member 2	Homo sapiens	68-74
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	279-283	solute carrier family 11 member 2	Homo sapiens	88-116
33797709-7	2022	Interestingly sevelamer, lanthanum, iron-based phosphate binders, and iron supplement significantly lowered FGF23 levels.	Iron	36-40	fibroblast growth factor 23	Homo sapiens	108-113
33797709-7	2022	Interestingly sevelamer, lanthanum, iron-based phosphate binders, and iron supplement significantly lowered FGF23 levels.	Iron	70-74	fibroblast growth factor 23	Homo sapiens	108-113
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	279-283	solute carrier family 11 member 2	Homo sapiens	118-122
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	279-283	solute carrier family 11 member 2	Homo sapiens	128-157
11943663-1	2002	The capacity of natural resistance-associated macrophage protein-2 [Nramp2; also called divalent metal transporter-1 (DMT1) and divalent cation transporter-1 (DCT1)] to transport iron and its ubiquitous expression make it a likely candidate for transferrin-independent uptake of iron in peripheral tissues.	Iron	279-283	solute carrier family 11 member 2	Homo sapiens	159-163
33393188-0	2021	Coaction of hepatic thioredoxin and glutathione systems in iron overload-induced oxidative stress.	Iron	59-63	thioredoxin 1	Mus musculus	20-31
11943663-2	2002	We tested the hypothesis that non-transferrin-bound iron uptake by airway epithelial cells is associated with Nramp2/DMT1/DCT1 and that exposure to iron can increase Nramp2/DMT1/DCT1 mRNA and protein expression and transport of this metal.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	110-116
33393188-1	2021	In the present study, we demonstrate the coaction of thioredoxin and glutathione (GSH) systems in mouse liver against iron overload-induced oxidative stress (OS).	Iron	118-122	thioredoxin 1	Mus musculus	53-64
33393188-4	2021	To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	89-97
11943663-2	2002	We tested the hypothesis that non-transferrin-bound iron uptake by airway epithelial cells is associated with Nramp2/DMT1/DCT1 and that exposure to iron can increase Nramp2/DMT1/DCT1 mRNA and protein expression and transport of this metal.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	117-121
33393188-4	2021	To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	99-103
33393188-4	2021	To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction.	Iron	15-19	ferritin heavy polypeptide 1	Mus musculus	140-144
11943663-2	2002	We tested the hypothesis that non-transferrin-bound iron uptake by airway epithelial cells is associated with Nramp2/DMT1/DCT1 and that exposure to iron can increase Nramp2/DMT1/DCT1 mRNA and protein expression and transport of this metal.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	122-126
33393188-4	2021	To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction.	Iron	162-166	hepcidin antimicrobial peptide	Mus musculus	89-97
33393188-4	2021	To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction.	Iron	162-166	hepcidin antimicrobial peptide	Mus musculus	99-103
33393188-4	2021	To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction.	Iron	162-166	ferritin heavy polypeptide 1	Mus musculus	140-144
33393188-13	2021	In conclusion, excess iron accumulation in mouse liver tissue causes OS, which affects the redox state of the thioredoxin and GSH systems, inducing cell apoptosis and also ferroptosis due to increased lipid peroxidation and the depletion of GSH level.	Iron	22-26	thioredoxin 1	Mus musculus	110-121
11943663-2	2002	We tested the hypothesis that non-transferrin-bound iron uptake by airway epithelial cells is associated with Nramp2/DMT1/DCT1 and that exposure to iron can increase Nramp2/DMT1/DCT1 mRNA and protein expression and transport of this metal.	Iron	148-152	solute carrier family 11 member 2	Homo sapiens	166-172
11943663-2	2002	We tested the hypothesis that non-transferrin-bound iron uptake by airway epithelial cells is associated with Nramp2/DMT1/DCT1 and that exposure to iron can increase Nramp2/DMT1/DCT1 mRNA and protein expression and transport of this metal.	Iron	148-152	solute carrier family 11 member 2	Homo sapiens	173-177
33869196-8	2021	The overexpression of TRIM26 inhibited HSCs proliferation, promoted lipid peroxidation, manipulated ferroptosis-related factor expressions, and counteracted the effect of iron inhibitor deferoxamine.	Iron	171-175	tripartite motif-containing 26	Mus musculus	22-28
11943663-2	2002	We tested the hypothesis that non-transferrin-bound iron uptake by airway epithelial cells is associated with Nramp2/DMT1/DCT1 and that exposure to iron can increase Nramp2/DMT1/DCT1 mRNA and protein expression and transport of this metal.	Iron	148-152	solute carrier family 11 member 2	Homo sapiens	178-182
11943663-5	2002	The Nramp2/DMT1/DCT1 mRNA isoform without an iron-response element (IRE) increased with exposure of BEAS-2B cells to FAC.	Iron	45-49	solute carrier family 11 member 2	Homo sapiens	4-10
11943663-5	2002	The Nramp2/DMT1/DCT1 mRNA isoform without an iron-response element (IRE) increased with exposure of BEAS-2B cells to FAC.	Iron	45-49	solute carrier family 11 member 2	Homo sapiens	11-15
11943663-5	2002	The Nramp2/DMT1/DCT1 mRNA isoform without an iron-response element (IRE) increased with exposure of BEAS-2B cells to FAC.	Iron	45-49	solute carrier family 11 member 2	Homo sapiens	16-20
33937615-5	2021	Fluorescent imaging of maternally injected transferrin iron in the placentas collected at 6 time points postinjection (n = 1-3 animals/time point) showed that transferrin iron was taken up and metabolized within syncytiotrophoblast I within 48 h after injection.	Iron	55-59	transferrin	Mus musculus	159-170
11943663-10	2002	We conclude that airway epithelial cells increase mRNA and expression of the Nramp2/DMT1/DCT1 without an IRE after exposure to iron.	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	77-83
33937615-5	2021	Fluorescent imaging of maternally injected transferrin iron in the placentas collected at 6 time points postinjection (n = 1-3 animals/time point) showed that transferrin iron was taken up and metabolized within syncytiotrophoblast I within 48 h after injection.	Iron	171-175	transferrin	Mus musculus	43-54
33937615-5	2021	Fluorescent imaging of maternally injected transferrin iron in the placentas collected at 6 time points postinjection (n = 1-3 animals/time point) showed that transferrin iron was taken up and metabolized within syncytiotrophoblast I within 48 h after injection.	Iron	171-175	transferrin	Mus musculus	159-170
11943663-10	2002	We conclude that airway epithelial cells increase mRNA and expression of the Nramp2/DMT1/DCT1 without an IRE after exposure to iron.	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	84-88
11943663-10	2002	We conclude that airway epithelial cells increase mRNA and expression of the Nramp2/DMT1/DCT1 without an IRE after exposure to iron.	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	89-93
12051835-15	2002	Fet4p is not the only metal transporter that is negatively regulated by oxygen; we find that Rox1p also represses S. cerevisiae SMF3, proposed to function in vacuolar iron transport.	Iron	167-171	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	128-132
33188427-6	2021	However, Fe deficiency-induced resistance functions independently of the ISR regulators MYB72 and BGLU42, indicating that both types of induced resistance are regulated in a different manner.	Iron	9-11	beta glucosidase 42	Arabidopsis thaliana	98-104
33449088-10	2021	We discuss the key regulatory network of bHLH transcription factors, including FIT, subgroup Ib, subgroup IVc and URI (bHLH121), crucial for regulating Fe uptake in Arabidopsis thaliana.	Iron	152-154	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	119-126
11897618-6	2002	In controls, we found inverse relationships between the DCT1 splice form containing an iron-responsive element (IRE) and blood hemoglobin, serum transferrin saturation, or ferritin.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	56-60
33486765-2	2021	Erythroferrone (ERFE) and growth/differentiation factor 15 (GDF15) are two regulators of iron homeostasis produced by erythroid progenitors.	Iron	89-93	growth differentiation factor 15	Homo sapiens	26-58
33486765-2	2021	Erythroferrone (ERFE) and growth/differentiation factor 15 (GDF15) are two regulators of iron homeostasis produced by erythroid progenitors.	Iron	89-93	growth differentiation factor 15	Homo sapiens	60-65
33486765-3	2021	Elevated systemic levels of ERFE and GDF15 in MDS are associated with dysregulated iron metabolism and iron overload, which is especially pronounced in MDS with SF3B1 gene mutations.	Iron	83-87	growth differentiation factor 15	Homo sapiens	37-42
11897618-11	2002	Our data show that expression levels of human DCT1 mRNA, and to a lesser extent IREG1 mRNA, are regulated in an iron-dependent manner, whereas mRNA of hephaestin is not affected.	Iron	112-116	solute carrier family 11 member 2	Homo sapiens	46-50
11897618-11	2002	Our data show that expression levels of human DCT1 mRNA, and to a lesser extent IREG1 mRNA, are regulated in an iron-dependent manner, whereas mRNA of hephaestin is not affected.	Iron	112-116	solute carrier family 40 member 1	Homo sapiens	80-85
12006174-13	2002	As CO and iron, respectively the inducer and the inhibitor of VEGF synthesis, are concomitantly produced during the degradation of heme, these data indicate that HO by-products may differentially modulate VEGF production.	Iron	10-14	vascular endothelial growth factor A	Rattus norvegicus	205-209
32613329-1	2021	PURPOSE: We evaluated the effectiveness of iron supplementation in relation to baseline iron and inflammatory status of pregnant women and their offspring in Sri Lanka.	Iron	43-47	sorcin	Homo sapiens	158-161
11832331-0	2002	Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism.	Iron	48-52	ceruloplasmin	Homo sapiens	10-23
33673530-9	2021	The present results suggest an iron status-independent alteration of ferroportin and hephaestin proteins in children with histologically confirmed celiac disease.	Iron	31-35	hephaestin	Homo sapiens	85-95
11832331-0	2002	Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism.	Iron	85-89	ceruloplasmin	Homo sapiens	10-23
11842004-9	2002	Since paraferritin functions to reduce newly transported ferric iron to ferrous iron and DMT-1 can transport ferrous iron, these findings suggest a role for DMT-1 in conveyance of iron from paraferritin to ferrochelatase, the enzyme utilizing ferrous iron for the synthesis of heme in the mitochondrion.	Iron	80-84	solute carrier family 11 member 2	Homo sapiens	157-162
33668157-8	2021	Our study points at copper and iron homeostasis as a potential therapeutic target for further investigation in higher eukaryotic models of VPS13-related diseases.	Iron	31-35	membrane morphogenesis protein VPS13	Saccharomyces cerevisiae S288C	139-144
11861299-4	2002	We generated beta-globin gene constructs with this mutation and an iron-responsive element in the 5" untranslated region, which allowed specific experimental activation and inactivation of translation and, hence, NMD of this transcript.	Iron	67-71	hemoglobin subunit beta	Homo sapiens	13-24
33450374-7	2021	Genes linking iron homeostasis and lipid metabolism including stearoyl coenzyme A desaturase 1 (SCD1) are up-regulated in ovarian cancer spheroids.	Iron	14-18	stearoyl-CoA desaturase	Homo sapiens	62-94
33450374-7	2021	Genes linking iron homeostasis and lipid metabolism including stearoyl coenzyme A desaturase 1 (SCD1) are up-regulated in ovarian cancer spheroids.	Iron	14-18	stearoyl-CoA desaturase	Homo sapiens	96-100
33450374-8	2021	The product of SCD1 oleic acid can restore the viability of ovarian cancer spheroids inhibited by deprivation of iron.	Iron	113-117	stearoyl-CoA desaturase	Homo sapiens	15-19
33571427-5	2021	We show that constitutive or macrophage expression of a GOF Piezo1 allele in mice disrupts levels of the iron regulator hepcidin and causes iron overload.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	120-128
11886477-3	2002	In particular, the identification of the haemochromatosis gene (HFE) and more recently the transferrin receptor 2 gene (TfR2) together with the specific mutations in these genes which result in hepatic iron overload, has enhanced our understanding of the pathophysiology of haemochromatosis.	Iron	202-206	transferrin receptor 2	Homo sapiens	91-113
11886477-3	2002	In particular, the identification of the haemochromatosis gene (HFE) and more recently the transferrin receptor 2 gene (TfR2) together with the specific mutations in these genes which result in hepatic iron overload, has enhanced our understanding of the pathophysiology of haemochromatosis.	Iron	202-206	transferrin receptor 2	Homo sapiens	120-124
33594038-10	2021	However, students with ADM-high levels (were 25.7%) had significantly (p<0.05) better fat quality rates, as well as in intake values of iron, fiber, calcium and foods such as fruits and vegetables, whole grains, fish and skimmed dairy; also significantly low intake of industrial pastries, sugary drinks and snacks.	Iron	136-140	adrenomedullin	Homo sapiens	23-26
11869803-0	2002	Effects of ferroxidase activity and species on ceruloplasmin mediated iron uptake by BT325 cells.	Iron	70-74	ceruloplasmin	Homo sapiens	47-60
11869803-1	2002	In a previous study, we found that human ceruloplasmin (hCP) promotes iron uptake rather than release in BT325 cells, a human glioma cell line.	Iron	70-74	ceruloplasmin	Homo sapiens	41-54
11829747-2	2002	Smf1p and Smf2p are regulated at the post-translational level by manganese, whereas Smf3p is regulated by iron through a mechanism that, up until now, was unknown.	Iron	106-110	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	84-89
33049637-6	2021	Moreover, when it occurs at high concentration, Ca competes with Fe for OM binding leading to an increase in the amount of ferrihydrite-like nanoparticles and binding site availability.	Iron	65-67	oncomodulin 2	Homo sapiens	72-74
33049637-7	2021	As a consequence, Ca not only impacts the ionic strength but it also has a dramatic impact on the structural organization of Fe-OM aggregates at several scales of organization, resulting in an increase of their sorption capacity.	Iron	125-127	oncomodulin 2	Homo sapiens	128-130
11829747-4	2002	By comparison, iron regulation of Smf3p involves the upstream non-coding region of the gene.	Iron	15-19	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	34-39
11829747-5	2002	Using SMF3-lacZ reporter constructs, we identified two distinct regions of the SMF3 promoter that contribute to iron regulation: (1) approx.	Iron	112-116	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	79-83
11829747-7	2002	The -348 to -247 region by itself can confer strong iron regulation to the heterologous CYC1 core promoter, and therefore harbours a putative upstream activating sequence for iron.	Iron	52-56	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	88-92
33574380-10	2021	These findings suggest that MUTYH deficiency is associated with hepatocarcinogenesis in patients with NASH with hepatic iron accumulation.	Iron	120-124	mutY DNA glycosylase	Homo sapiens	28-33
11829747-7	2002	The -348 to -247 region by itself can confer strong iron regulation to the heterologous CYC1 core promoter, and therefore harbours a putative upstream activating sequence for iron.	Iron	175-179	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	88-92
11829747-8	2002	Iron regulation of SMF3 was dramatically reduced, but not completely eliminated, in strains lacking both the AFT1 and AFT2 iron regulatory factors.	Iron	0-4	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	19-23
11829747-8	2002	Iron regulation of SMF3 was dramatically reduced, but not completely eliminated, in strains lacking both the AFT1 and AFT2 iron regulatory factors.	Iron	123-127	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	19-23
11829747-9	2002	Together with the promoter mapping studies, these results suggest that both Aft-dependent and Aft-independent pathways may contribute to iron regulation of SMF3.	Iron	137-141	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	156-160
11829750-2	2002	In order to determine this iron pool, we synthesized a new fluorescent indicator, rhodamine B-[(1,10-phenanthrolin-5-yl)aminocarbonyl]benzyl ester (RPA).	Iron	27-31	replication protein A1	Homo sapiens	148-151
33496295-4	2021	Layer-resolved DMI calculations revealed that the sign of the spin-orbit coupling (SOC) energy was changed for Au near the interface of Au/Fe under tensile stress, subsequently reversing the chirality of the i-DMI from left-handed to right-handed.	Iron	139-141	spindlin 1	Homo sapiens	62-66
11829750-5	2002	The intramitochondrial RPA fluorescence was quenched when iron was added to the cells in a membrane-permeant form.	Iron	58-62	replication protein A1	Homo sapiens	23-26
11829750-7	2002	The concentration of mitochondrial chelatable iron in cultured rat hepatocytes, quantified from the increase in RPA fluorescence after addition of pyridoxal isonicotinoyl hydrazone, was found to be 12.2 +/- 4.9 microM.	Iron	46-50	replication protein A1	Homo sapiens	112-115
11829750-9	2002	In conclusion, RPA enables the selective determination of the highly physiologically and pathophysiologically interesting mitochondrial pool of chelatable iron in intact cells and to record the time course of alterations of this pool.	Iron	155-159	replication protein A1	Homo sapiens	15-18
33526170-3	2021	Iron release from ferritin storage is through nuclear receptor coactivator 4 (NCOA4)-mediated autophagic degradation, known as ferritinophagy.	Iron	0-4	nuclear receptor coactivator 4	Homo sapiens	78-83
11843096-4	2002	Recent studies suggest that an additional mechanism by which iron might contribute to PD is by inducing aggregation of the alpha-synuclein, which is a protein that accumulates in Lewy bodies in PD.	Iron	61-65	synuclein alpha	Homo sapiens	123-138
32193252-7	2021	Our data show that FGF23 is induced as early as pro-inflammatory cytokines in response to LPS, followed by upregulation of hepcidin and downregulation of erythropoietin (Epo) expression in addition to decreased serum iron and transferrin saturation.	Iron	217-221	fibroblast growth factor 23	Mus musculus	19-24
11689569-1	2002	Aceruloplasminemia is an inherited neurodegenerative disease characterized by parenchymal iron accumulation secondary to loss-of-function mutations in the ceruloplasmin gene.	Iron	90-94	ceruloplasmin	Homo sapiens	1-14
32193252-9	2021	Accordingly, iron sequestration in liver and spleen caused by TLR4 activation was completely abrogated by FGF23 signaling inhibition, resulting in alleviation of serum iron and transferrin saturation deficit.	Iron	13-17	fibroblast growth factor 23	Mus musculus	106-111
32193252-9	2021	Accordingly, iron sequestration in liver and spleen caused by TLR4 activation was completely abrogated by FGF23 signaling inhibition, resulting in alleviation of serum iron and transferrin saturation deficit.	Iron	13-17	transferrin	Mus musculus	177-188
32193252-9	2021	Accordingly, iron sequestration in liver and spleen caused by TLR4 activation was completely abrogated by FGF23 signaling inhibition, resulting in alleviation of serum iron and transferrin saturation deficit.	Iron	168-172	fibroblast growth factor 23	Mus musculus	106-111
33462465-3	2021	Here, we employ resonant inelastic X-ray scattering to investigate the spectrum of spin excitations in mesoscopic Fe films, from bulk-like films down to three unit cells.	Iron	114-116	spindlin 1	Homo sapiens	83-87
11750985-3	2002	As several lines of evidence indicate that oxidative stress and free radical damage occur in AD, the transferrin gene (TF) has been suggested as a candidate locus for AD since it is the major transport protein for iron, which itself is a major factor in free radical generation.	Iron	214-218	coagulation factor III, tissue factor	Homo sapiens	119-121
32464705-1	2021	AIMS: Neuroferritinopathyor Hereditary Ferritinopathy (HF)is an autosomal dominant movement disorder due to mutation in the light chain of the iron storage protein ferritin (FTL).HF is the only late-onset neurodegeneration with brain iron accumulation disorder andstudy of HF offers a unique opportunity to understand the role of iron in more common neurodegenerative syndromes.	Iron	143-147	ferritin light chain	Homo sapiens	174-177
32464705-1	2021	AIMS: Neuroferritinopathyor Hereditary Ferritinopathy (HF)is an autosomal dominant movement disorder due to mutation in the light chain of the iron storage protein ferritin (FTL).HF is the only late-onset neurodegeneration with brain iron accumulation disorder andstudy of HF offers a unique opportunity to understand the role of iron in more common neurodegenerative syndromes.	Iron	234-238	ferritin light chain	Homo sapiens	174-177
12572994-6	2002	The maintenance of an (S)-configured C-4 carbon is optimal in the design of desferrithiocin-based iron chelators.	Iron	98-102	complement C4A (Rodgers blood group)	Homo sapiens	37-40
33535496-4	2021	Cancer-related anemia (CRA) is characterized by a decreased circulating serum iron concentration and transferrin saturation despite ample iron stores, pointing to a more complex problem related to iron homeostatic regulation and additional factors such as chronic inflammatory status.	Iron	78-82	myotubularin related protein 11	Homo sapiens	0-27
33535496-4	2021	Cancer-related anemia (CRA) is characterized by a decreased circulating serum iron concentration and transferrin saturation despite ample iron stores, pointing to a more complex problem related to iron homeostatic regulation and additional factors such as chronic inflammatory status.	Iron	138-142	myotubularin related protein 11	Homo sapiens	0-27
33535496-4	2021	Cancer-related anemia (CRA) is characterized by a decreased circulating serum iron concentration and transferrin saturation despite ample iron stores, pointing to a more complex problem related to iron homeostatic regulation and additional factors such as chronic inflammatory status.	Iron	138-142	myotubularin related protein 11	Homo sapiens	0-27
12055353-5	2002	Characterization of this disorder revealed a critical physiological role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and has provided new insights into human iron metabolism and nutrition.	Iron	158-162	ceruloplasmin	Homo sapiens	77-90
11908636-1	2002	Ovotransferrin (formerly conalbumin) is an iron-binding protein present in birds.	Iron	43-47	transferrin (ovotransferrin)	Gallus gallus	0-14
32780358-7	2021	Thus, based on the obtained results, the expression of c-kit, STRA8, and PCNA genes was significantly increased in treatment groups by curcumin-loaded iron particles compared with scrotal hyperthermia-induced mice.	Iron	151-155	proliferating cell nuclear antigen	Mus musculus	73-77
33573082-8	2021	By contrast, both of them upregulate the Fe acquisition genes FRO2 and IRT1 (and FIT) under Fe deficiency.	Iron	41-43	iron-regulated transporter 1	Arabidopsis thaliana	71-75
11908641-1	2002	We have previously shown that iron-containing human lactoferrin (LF) purified from breast milk is able to form both in vitro and in vivo a complex with ceruloplasmin (CP), the copper-containing protein of human plasma.	Iron	30-34	ceruloplasmin	Homo sapiens	152-165
11908641-1	2002	We have previously shown that iron-containing human lactoferrin (LF) purified from breast milk is able to form both in vitro and in vivo a complex with ceruloplasmin (CP), the copper-containing protein of human plasma.	Iron	30-34	ceruloplasmin	Homo sapiens	167-169
11908647-2	2002	Moraxella bovis isolates were shown to specifically bind bovine lactoferrin (bLf) and bovine transferrin (bTf) and to use these proteins as a source of iron to support the growth of iron-limited cells.	Iron	182-186	lactotransferrin	Bos taurus	64-75
11908649-4	2002	While the iron-binding properties were originally believed to be solely responsible for the host defense properties ascribed to lactoferrin, it is now known that other mechanisms contribute to the broad spectrum anti-infective and anti-inflammatory roles of this protein.	Iron	10-14	lactotransferrin	Mus musculus	128-139
33477114-3	2021	Doping Fe at the Mn site leads to an increase in the spin reorientation temperature (TSR) from 33K (x=0) to 55K (x=0.1) while the TN remains nearly constant at 72K.	Iron	7-9	spindlin 1	Homo sapiens	53-57
12511980-1	2002	Lactoferrin (LF) is an iron-binding glycoprotein present in the cytoplasmic granules of neutrophils and in external secretions of mammals.	Iron	23-27	lactotransferrin	Bos taurus	0-11
12401952-4	2002	Morphological studies revealed that iron (50-100 microM) altered mitochondrial morphology, disrupted nuclear membrane, and translocated alpha-synuclein from perinuclear region into the disrupted nucleus.	Iron	36-40	synuclein alpha	Homo sapiens	136-151
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	126-130	Fit3p	Saccharomyces cerevisiae S288C	16-20
11673473-3	2001	Northern blot analysis confirmed that FIT1, FIT2, and FIT3 mRNA transcript levels were increased 60-230-fold in response to iron deprivation in an Aft1p-dependent manner.	Iron	124-128	Fit3p	Saccharomyces cerevisiae S288C	54-58
11673473-9	2001	Fit1p, Fit2p, and Fit3p may function by increasing the amount of iron associated with the cell wall and periplasmic space.	Iron	65-69	Fit3p	Saccharomyces cerevisiae S288C	18-23
11756598-1	2001	BACKGROUND: Aceruloplasminemia, an autosomal recessive disorder that affects human iron metabolism, is caused by mutation of the ceruloplasmin gene.	Iron	83-87	ceruloplasmin	Homo sapiens	13-26
11733990-6	2001	The main difference lies at the level of the bound cofactor, iron for PDF1B-like bacterial PDFs, and zinc for PDF1A.	Iron	61-65	peptide deformylase 1B	Arabidopsis thaliana	70-75
11724918-8	2001	The presence of alpha-synuclein in GCIs provides a link with Parkinson"s disease, dementia with Lewy bodies, and neurodegeneration with brain iron accumulation, type 1 (or Hallervorden-Spatz syndrome), in which alpha-synuclein is also found within Lewy bodies.	Iron	142-146	synuclein alpha	Homo sapiens	16-31
11707736-5	2001	Increased HO-1 protein was associated with a brisk and early increase in catalytically active iron and a robust increase in cellular ferritin.	Iron	94-98	heme oxygenase 1	Homo sapiens	10-14
11681312-0	2001	Ceruloplasmin promotes iron uptake rather than release in BT325 cells.	Iron	23-27	ceruloplasmin	Homo sapiens	0-13
11681312-1	2001	This study was initiated to investigate the mechanism of ceruloplasmin (CP)-mediated iron release from brain cells using BT325 cells (a glioblastoma cell line); however, negative results were obtained.	Iron	85-89	ceruloplasmin	Homo sapiens	57-70
11681312-1	2001	This study was initiated to investigate the mechanism of ceruloplasmin (CP)-mediated iron release from brain cells using BT325 cells (a glioblastoma cell line); however, negative results were obtained.	Iron	85-89	ceruloplasmin	Homo sapiens	72-74
11681312-5	2001	When the cells were incubated with 1 microM 59Fe2+ in the presence of varying amounts of CP for 30 min at 37 degrees C, it was found that CP increased iron uptake.	Iron	151-155	ceruloplasmin	Homo sapiens	138-140
11681312-6	2001	The total iron uptake by BT325 cells in CP treatment groups (25, 75, 150, 300 microg/ml) was significantly higher than that in the control (no CP addition) (all P&lt;0.01).	Iron	10-14	ceruloplasmin	Homo sapiens	40-42
11681312-7	2001	Furthermore, in contrast to our expectation, CP was shown to promote significantly iron uptake in not only iron-sufficient but also iron-deficient cells.	Iron	83-87	ceruloplasmin	Homo sapiens	45-47
11681312-7	2001	Furthermore, in contrast to our expectation, CP was shown to promote significantly iron uptake in not only iron-sufficient but also iron-deficient cells.	Iron	107-111	ceruloplasmin	Homo sapiens	45-47
11681312-7	2001	Furthermore, in contrast to our expectation, CP was shown to promote significantly iron uptake in not only iron-sufficient but also iron-deficient cells.	Iron	107-111	ceruloplasmin	Homo sapiens	45-47
11681312-8	2001	These results showed that CP had a role in iron uptake rather than release in BT325 cells.	Iron	43-47	ceruloplasmin	Homo sapiens	26-28
11695366-2	2001	It has an essential requirement for iron, which it obtains from host lactoferrin.	Iron	36-40	lactotransferrin	Bos taurus	69-80
11344015-0	2001	Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP).	Iron	0-4	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	88-92
11344015-3	2001	Our study demonstrated that iron staining was more intense in ARJP than in both controls and sporadic Parkinson"s disease (PD), and there were differences in the pattern of distribution of iron staining between ARJP and PD.	Iron	28-32	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	62-66
11344015-3	2001	Our study demonstrated that iron staining was more intense in ARJP than in both controls and sporadic Parkinson"s disease (PD), and there were differences in the pattern of distribution of iron staining between ARJP and PD.	Iron	189-193	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	211-215
11344015-4	2001	In addition neurites of SN in ARJP showed intense iron staining.	Iron	50-54	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	30-34
11549466-1	2001	Phytanoyl-CoA 2-hydroxylase (PAHX), an iron(II) and 2-oxoglutarate-dependent oxygenase, catalyses an essential step in the mammalian metabolism of beta-methylated fatty acids.	Iron	39-43	phytanoyl-CoA 2-hydroxylase	Homo sapiens	0-27
11549466-1	2001	Phytanoyl-CoA 2-hydroxylase (PAHX), an iron(II) and 2-oxoglutarate-dependent oxygenase, catalyses an essential step in the mammalian metabolism of beta-methylated fatty acids.	Iron	39-43	phytanoyl-CoA 2-hydroxylase	Homo sapiens	29-33
11551515-13	2001	Results suggest that specific ROS generated in iron-dependent reactions, different from lipid peroxyl radicals, are involved in PLA(2) activation, this process being important in TBHP-induced hepatocyte injury.	Iron	47-51	phospholipase A2 group IB	Rattus norvegicus	128-134
11575788-4	2001	The HPLC-ICPMS results for the iron speciation analysis of a raw beef steak, used as an analytical quality control (AQC) sample, showed that the main iron biomolecule present was the heme iron-containing protein myoglobin.	Iron	150-154	myoglobin	Homo sapiens	212-221
11575788-4	2001	The HPLC-ICPMS results for the iron speciation analysis of a raw beef steak, used as an analytical quality control (AQC) sample, showed that the main iron biomolecule present was the heme iron-containing protein myoglobin.	Iron	150-154	myoglobin	Homo sapiens	212-221
11535048-10	2001	Fluorescence quenching experiments with peptides derived from the glycine-extended gastrin(17) sequence indicated that one or more of the five glutamic acid residues were necessary for iron binding.	Iron	185-189	gastrin	Homo sapiens	83-90
11502556-9	2001	Our results suggest that Fe and Cd are transported in MDCK cells by a transporter with biochemical properties similar to those of DMT1.	Iron	25-27	solute carrier family 11 member 2	Homo sapiens	130-134
11592689-9	2001	This difference from X-ray diffraction originates from the incoherent nature of the Mossbauer effect together with its high-energy resolution, which yields the self-correlation, and the temporal behavior of individual Fe atoms in the myoglobin crystal.	Iron	218-220	myoglobin	Homo sapiens	234-243
33462793-11	2021	In conclusion, iron treatment was associated with a significant decrease in FGF23 levels in CKD patients.	Iron	15-19	fibroblast growth factor 23	Homo sapiens	76-81
11493598-0	2001	An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins.	Iron	103-105	growth factor, augmenter of liver regeneration	Homo sapiens	62-67
33467196-8	2021	VIT-2763 alone decreased serum iron and transferrin saturation (TSAT) but was not able to reduce the liver iron concentration.	Iron	31-35	vitrin	Mus musculus	0-3
33467196-12	2021	In conclusion, co-administration of the oral ferroportin inhibitor VIT-2763 and the iron chelator DFX is feasible and might offer an opportunity to improve both ineffective erythropoiesis and iron overload in beta-thalassemia.	Iron	192-196	vitrin	Mus musculus	67-70
11493598-0	2001	An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins.	Iron	103-105	growth factor, augmenter of liver regeneration	Homo sapiens	68-71
11551744-7	2001	Preconditioning induction of stress proteins (i.e., hemeoxygenase-1 and neuronal nitric oxide synthase) and hypothermia therapy suppress the generation of toxic reactive oxygen, lipid, and thiol species evoked by bioactive iron complexes in the brain.	Iron	223-227	heme oxygenase 1	Homo sapiens	52-67
33469535-7	2020	Results: Iron overloaded mice exhibited greater cartilage destruction and elevated ADAMTS5 as well as MMP13 expression along with increased iron accumulation and dysregulated iron regulators.	Iron	9-13	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	83-90
11439223-1	2001	Divalent metal transporter 1 (DMT1) is a transmembrane, proton-coupled metal ion transporter that is upregulated in the duodenum of iron-deficient rodents and in hereditary hemochromatosis patients, suggesting that it may constitute a key factor in the uptake of dietary iron.	Iron	132-136	solute carrier family 11 member 2	Homo sapiens	0-28
32485264-0	2021	Cow milk protein beta-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells.	Iron	94-98	beta-lactoglobulin	Bos taurus	17-35
32485264-13	2021	Holo-BLG shuttled iron into monocytic cells and impaired their antigen-presentation.	Iron	18-22	beta-lactoglobulin	Bos taurus	5-8
32768735-3	2021	The presence of FeOx on the CNF plays a vital role in determining the morphology and structure of the final hybrids, and the Mn3O4-Fe3O4@C hybrids with half-tube, tube and oolite-filled fibers are formed conveniently by tuning Fe content in the carbon fiber precursor.	Iron	16-18	NPHS1 adhesion molecule, nephrin	Homo sapiens	28-31
11439223-1	2001	Divalent metal transporter 1 (DMT1) is a transmembrane, proton-coupled metal ion transporter that is upregulated in the duodenum of iron-deficient rodents and in hereditary hemochromatosis patients, suggesting that it may constitute a key factor in the uptake of dietary iron.	Iron	132-136	solute carrier family 11 member 2	Homo sapiens	30-34
32574785-0	2021	NMDA receptor modulates spinal iron accumulation via activating DMT1(-)IRE in remifentanil-induced hyperalgesia.	Iron	31-35	RoBo-1	Rattus norvegicus	64-68
11439223-1	2001	Divalent metal transporter 1 (DMT1) is a transmembrane, proton-coupled metal ion transporter that is upregulated in the duodenum of iron-deficient rodents and in hereditary hemochromatosis patients, suggesting that it may constitute a key factor in the uptake of dietary iron.	Iron	271-275	solute carrier family 11 member 2	Homo sapiens	0-28
11439223-1	2001	Divalent metal transporter 1 (DMT1) is a transmembrane, proton-coupled metal ion transporter that is upregulated in the duodenum of iron-deficient rodents and in hereditary hemochromatosis patients, suggesting that it may constitute a key factor in the uptake of dietary iron.	Iron	271-275	solute carrier family 11 member 2	Homo sapiens	30-34
11439223-7	2001	No effects were observed at 24 h. Gene expression of DMT1 in the iron-treated Caco-2 cells was reduced by about 50% at 3 and 7 days and thus, correlated well with the uptake of cadmium.	Iron	65-69	solute carrier family 11 member 2	Homo sapiens	53-57
33160991-0	2021	Ambient fine particulate matter aggravates atherosclerosis in apolipoprotein E knockout mice by iron overload via the hepcidin-ferroportin axis.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	118-126
11389698-5	2001	Similarly, expression of the iron-responsive element (IRE)-regulated form of the divalent metal transporter 1 (DMT1) was also increased.	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	81-109
11389698-5	2001	Similarly, expression of the iron-responsive element (IRE)-regulated form of the divalent metal transporter 1 (DMT1) was also increased.	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	111-115
32743932-8	2021	RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use.	Iron	220-224	fibroblast growth factor 23	Homo sapiens	40-45
11389698-8	2001	Iron efflux is thought to be mediated by the metal transporter protein, IREG1/ferroportin1/MTP1, and oxidation of Fe(II) to Fe(III) prior to incorporation into fetal transferrin is carried out by the placental copper oxidase.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	72-77
11389698-8	2001	Iron efflux is thought to be mediated by the metal transporter protein, IREG1/ferroportin1/MTP1, and oxidation of Fe(II) to Fe(III) prior to incorporation into fetal transferrin is carried out by the placental copper oxidase.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	78-90
11389698-8	2001	Iron efflux is thought to be mediated by the metal transporter protein, IREG1/ferroportin1/MTP1, and oxidation of Fe(II) to Fe(III) prior to incorporation into fetal transferrin is carried out by the placental copper oxidase.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	91-95
33424282-7	2021	CHr values showed a significant correlations with RBCs, Hb- hemoglobin, Hct- hematocrit level, MCV- mean corpuscular volume, MCH- mean corpuscular hemoglobin, MCHC, RDW- red cell distribution width , SI-Serum Iron, TIBC- Total iron binding capacity and TSAT- Transferrin saturation.	Iron	209-213	chromate resistance; sulfate transport	Homo sapiens	0-3
11278828-2	2001	gas-1 encodes a close homologue of the 49-kDa iron protein subunit of Complex I of the mitochondrial electron transport chain from bovine heart.	Iron	46-50	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	0-5
33424282-7	2021	CHr values showed a significant correlations with RBCs, Hb- hemoglobin, Hct- hematocrit level, MCV- mean corpuscular volume, MCH- mean corpuscular hemoglobin, MCHC, RDW- red cell distribution width , SI-Serum Iron, TIBC- Total iron binding capacity and TSAT- Transferrin saturation.	Iron	227-231	chromate resistance; sulfate transport	Homo sapiens	0-3
11472021-3	2001	The one-electron reduction of CcP-I produces a second enzyme intermediate, CcP compound II (CcP-II), which contains an oxyferryl, Fe(IV), heme.	Iron	130-132	granzyme B	Homo sapiens	30-35
33396831-3	2020	Ferroportin (Fpn), the only known cellular iron exporter, as well as hephaestin (Heph) and ceruloplasmin, two copper-dependent ferroxidases involved in the above-mentioned processes, are key elements of the interaction between copper and iron metabolisms.	Iron	238-242	hephaestin	Homo sapiens	69-79
33396831-3	2020	Ferroportin (Fpn), the only known cellular iron exporter, as well as hephaestin (Heph) and ceruloplasmin, two copper-dependent ferroxidases involved in the above-mentioned processes, are key elements of the interaction between copper and iron metabolisms.	Iron	238-242	hephaestin	Homo sapiens	81-85
11384210-4	2001	Here we report that, 5 weeks after a single oral dose of TCDD (75 microg/kg), Cyp1a2(+/+) wild-type mice showed severe uroporphyria and greater than 90% decreases in UROD activity; in contrast, despite exposure to this potent agent Cyp1a2(-/-) knockout mice displayed absolutely no increases in hepatic porphyrin levels, even after prior iron overload, and no detectable inhibition of UROD activity.	Iron	338-342	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	78-84
33367500-7	2021	Adults in the highest quartile of plasma GDF-15 had an increased risk of developing anemia (Hazards Ratio 1.15, 95% Confidence Interval 1.09, 1.21, P<.0001) compared to those in the lower three quartiles in a multivariable Cox proportional hazards model adjusting for age, sex, serum iron, soluble transferrin receptor, ferritin, vitamin B12, congestive heart failure, diabetes mellitus, and cancer.	Iron	284-288	growth differentiation factor 15	Homo sapiens	41-47
11313241-12	2001	The identification of new mutations of TFR2 confirms that this gene is associated with iron overload and offers a tool for molecular diagnosis in patients without HFE mutations.	Iron	87-91	transferrin receptor 2	Homo sapiens	39-43
33392212-6	2020	Recent research has revealed a bidirectional relationship between fibroblast growth factor 23 (FGF23) and iron status, anemia, and inflammation, as well as the role of erythroferrone (ERFE) in iron homeostasis.	Iron	106-110	fibroblast growth factor 23	Homo sapiens	66-93
33392212-6	2020	Recent research has revealed a bidirectional relationship between fibroblast growth factor 23 (FGF23) and iron status, anemia, and inflammation, as well as the role of erythroferrone (ERFE) in iron homeostasis.	Iron	106-110	fibroblast growth factor 23	Homo sapiens	95-100
11313311-0	2001	Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload.	Iron	27-31	solute carrier family 11 member 2	Homo sapiens	45-73
11334672-7	2001	TcR expansions were found more frequent in patients with iron overload related pathology than in patients without pathology.	Iron	57-61	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	0-3
33012507-6	2020	Homozygous mutant dZnT1 is lethal, with substantial zinc accumulation in the iron cell region, posterior midgut as well as gastric caeca.	Iron	77-81	Zinc transporter 63C	Drosophila melanogaster	18-23
11121422-1	2001	The crystal structure of heme oxygenase-1 suggests that Asp-140 may participate in a hydrogen bonding network involving ligands coordinated to the heme iron atom.	Iron	152-156	heme oxygenase 1	Homo sapiens	25-41
32798868-3	2020	The objective of this research was to study microbial redox cycles of iron in ZVI oxidation and deca-brominated diphenyl ether (deca-BDE) removal.	Iron	70-74	homeobox D13	Homo sapiens	133-136
32798868-9	2020	ZVI oxidation activity by IORB only increased to 13.14% and 37.0% in the absence and presence of deca-BDE, respectively.	Iron	0-3	homeobox D13	Homo sapiens	102-105
32798868-12	2020	Deca-BDE significantly influenced the effects of iron-metabolizing microorganisms on ZVI oxidation by altering the composition of microbial communities.	Iron	49-53	homeobox D13	Homo sapiens	5-8
32798868-12	2020	Deca-BDE significantly influenced the effects of iron-metabolizing microorganisms on ZVI oxidation by altering the composition of microbial communities.	Iron	85-88	homeobox D13	Homo sapiens	5-8
12947616-1	2001	In this paper, ultraviolet spectra and infrared spectra were used in the characterization of the reaction in which carbonyls in trinuclear-iron cluster and trinuclear-ruthenium cluster were substituted by Ph2C2 and PPh3 respectively.	Iron	139-143	protein phosphatase 4 catalytic subunit	Homo sapiens	215-219
33296542-2	2021	Since the discovery of the first ZIPs in 1990s, the ZIP family has been expanding to contain tens of thousands of members playing key roles in uptake and homeostasis of life-essential trace elements, primarily zinc, iron and manganese.	Iron	216-220	death associated protein kinase 3	Homo sapiens	33-36
11875282-1	2001	We have studied by immunocytochemistry, the distribution of DMT-1, a cellular iron transporter responsible for transport of metal irons from the plasma membrane to endosomes, in the normal monkey cerebral neocortex and hippocampus.	Iron	130-135	doublesex and mab-3 related transcription factor 1	Homo sapiens	60-65
33298951-5	2020	The enzymatic activity of human ALAD is greatly reduced upon loss of its Fe-S cluster, which results in reduced heme biosynthesis in human cells.	Iron	73-77	aminolevulinate dehydratase	Homo sapiens	32-36
33298951-6	2020	As ALAD provides an early Fe-S-dependent checkpoint in the heme biosynthetic pathway, our findings help explain why heme biosynthesis depends on intact ISC biogenesis.	Iron	26-28	aminolevulinate dehydratase	Homo sapiens	3-7
11875282-6	2001	The observation that DMT-1 was present on astrocytic endfeet suggests that these cells are involved in uptake of iron from endothelial cells.	Iron	113-117	doublesex and mab-3 related transcription factor 1	Homo sapiens	21-26
11354462-1	2001	Bovine lactoferricin is a 25-residue antibacterial peptide isolated after gastric cleavage of the iron transporting protein lactoferrin.	Iron	98-102	lactotransferrin	Bos taurus	124-135
33205790-3	2020	As high as 35% of the Fe atoms were deduced to be associated with the A2 type of disordering in Co2FeAl, which provides a basic understanding of the observed much lower value of spin polarization as observed in this system against the high value predicted theoretically.	Iron	22-24	spindlin 1	Homo sapiens	178-182
33272193-3	2020	We recently identified an aspartate ammonia-lyase (aspA) in P. multocida that was significantly upregulated under iron-restricted conditions, the protein of which could effectively protect chicken flocks against P. multocida.	Iron	114-118	aspartate ammonia-lyase	Pasteurella multocida	26-49
11299349-8	2001	Similar to transfer cells, the formation of extra root hairs in the Arabidopsis mutant man1 was regulated by the iron concentration of the growth medium and was unaffected by interorgan signaling.	Iron	113-117	Glycosyl hydrolase superfamily protein	Arabidopsis thaliana	87-91
33272193-3	2020	We recently identified an aspartate ammonia-lyase (aspA) in P. multocida that was significantly upregulated under iron-restricted conditions, the protein of which could effectively protect chicken flocks against P. multocida.	Iron	114-118	aspartate ammonia-lyase	Pasteurella multocida	51-55
33272193-8	2020	Moreover, growth of  aspA::kan was more seriously impaired than that of the wild-type strain under iron-restricted conditions, and this growth recovered after supplementation with iron ions.	Iron	99-103	aspartate ammonia-lyase	Pasteurella multocida	21-25
33272193-8	2020	Moreover, growth of  aspA::kan was more seriously impaired than that of the wild-type strain under iron-restricted conditions, and this growth recovered after supplementation with iron ions.	Iron	180-184	aspartate ammonia-lyase	Pasteurella multocida	21-25
33272193-9	2020	AspA transcription was negatively regulated by iron conditions, as demonstrated by quantitative reverse transcription-polymerase chain reaction.	Iron	47-51	aspartate ammonia-lyase	Pasteurella multocida	0-4
33272193-11	2020	CONCLUSION: These results demonstrate that aspA is required for bacterial growth in complex medium, and under anaerobic, acid, and iron-limited conditions.	Iron	131-135	aspartate ammonia-lyase	Pasteurella multocida	43-47
11120744-4	2001	The yeast genome contains five additional FRE1 and FRE2 homologues, four of which are regulated by iron and the major iron-dependent transcription factor, Aft1p, but whose function remains unknown.	Iron	99-103	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	51-55
11120744-4	2001	The yeast genome contains five additional FRE1 and FRE2 homologues, four of which are regulated by iron and the major iron-dependent transcription factor, Aft1p, but whose function remains unknown.	Iron	118-122	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	51-55
33287205-0	2020	Enhanced Cadmium Accumulation and Tolerance in Transgenic Hairy Roots of Solanum nigrum L. Expressing Iron-Regulated Transporter Gene IRT1.	Iron	102-106	iron-regulated transporter 1	Arabidopsis thaliana	134-138
11120744-5	2001	Fre3p was required for the reduction and uptake of ferrioxamine B-iron and for growth on ferrioxamine B, ferrichrome, triacetylfusarinine C, and rhodotorulic acid in the absence of Fre1p and Fre2p.	Iron	66-70	ferric-chelate reductase	Saccharomyces cerevisiae S288C	0-5
33287205-2	2020	In the present study, the hairy roots of Solanum nigrum L. were selected as a model plant system to study the potential application of Iron-regulated Transporter Gene (IRT1) for the efficient phytoremediation of Cd pollution.	Iron	135-139	iron-regulated transporter 1	Arabidopsis thaliana	168-172
11300822-5	2001	Electron paramagnetic resonance at 15 K further indicated that the iron-histidine bond is cleaved to form a five-coordinate derivative in some fraction of the myoglobin.	Iron	67-71	myoglobin	Homo sapiens	159-168
33273540-0	2020	The impact of Fe atom on the spin-filter and spin thermoelectric properties of Au-Fe@C20-Au monomer and dimer systems.	Iron	14-16	spindlin 1	Homo sapiens	29-33
33273540-0	2020	The impact of Fe atom on the spin-filter and spin thermoelectric properties of Au-Fe@C20-Au monomer and dimer systems.	Iron	14-16	spindlin 1	Homo sapiens	45-49
33273540-0	2020	The impact of Fe atom on the spin-filter and spin thermoelectric properties of Au-Fe@C20-Au monomer and dimer systems.	Iron	82-84	spindlin 1	Homo sapiens	29-33
33273540-0	2020	The impact of Fe atom on the spin-filter and spin thermoelectric properties of Au-Fe@C20-Au monomer and dimer systems.	Iron	82-84	spindlin 1	Homo sapiens	45-49
11298926-5	2001	Peptides 1, 3, 4 and 5 and Lf suppressed iron uptake by Candida cells, inversely correlated with their Candida cell growth inhibition activities.	Iron	41-45	lactotransferrin	Bos taurus	27-29
33273540-3	2020	Our results indicate that the presence of Fe atoms enhances substantially the spin-filter and increases the spin figure of merit in the dimer system.	Iron	42-44	spindlin 1	Homo sapiens	78-82
33273540-3	2020	Our results indicate that the presence of Fe atoms enhances substantially the spin-filter and increases the spin figure of merit in the dimer system.	Iron	42-44	spindlin 1	Homo sapiens	108-112
33273556-2	2020	As the major producer of hepcidin, the liver is central to the regulation of iron metabolism.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	25-33
32919110-11	2020	Iron modified FGF23 in both sexes, associating positively with iFGF23 and inversely with cFGF23.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	14-19
11479773-1	2001	There is accumulating evidence that ceruloplasmin, a copper-containing protein with ferroxidase activity, plays an important role in iron metabolism.	Iron	133-137	ceruloplasmin	Homo sapiens	36-49
32919110-17	2020	Iron modifies FGF23 in both sexes.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	14-19
11479773-2	2001	Reduction of ferroxidase activity secondary to ceruloplasmin deficiency may induce iron accumulation in various organs as the result of impaired iron transport.	Iron	83-87	ceruloplasmin	Homo sapiens	47-60
32521439-1	2020	The aim of this study was to determine how folate and iron deficiency, and the subsequent supplementation of rats" diet with these nutrients, affects Slc19a1and Tfr2 gene expression and the metabolism of folate and iron.	Iron	54-58	transferrin receptor 2	Rattus norvegicus	161-165
11479773-2	2001	Reduction of ferroxidase activity secondary to ceruloplasmin deficiency may induce iron accumulation in various organs as the result of impaired iron transport.	Iron	145-149	ceruloplasmin	Homo sapiens	47-60
11342215-4	2001	HIRIP5 has highly conserved homologs in both prokaryotes and eukaryotes, including the NFU1 gene product which has been implicated in iron metabolism in mitochondria of the yeast Saccharomyces cerevisiae.	Iron	134-138	NFU1 iron-sulfur cluster scaffold	Homo sapiens	0-6
33035800-2	2020	Rep1 polymorphism in the promotor region of SNCA is associated with risk of Parkinson"s disease, however its association with RLS and iron status is unclear.	Iron	134-138	CHM Rab escort protein	Homo sapiens	0-4
33035800-9	2020	Phenotypic analysis demonstrated that longer Rep1 alleles were associated with increased susceptibility to iron deficiency (53.0% vs 36.1%, P = 0.017), however had no phenotypic significant effects on age, gender, onset age, duration, RLS family history, severity, laterality, extra body involvement and seasonal fluctuation.	Iron	107-111	CHM Rab escort protein	Homo sapiens	45-49
33068888-0	2020	Reprogramming of a human induced pluripotent stem cell (iPSC) line from a patient with neurodegeneration with brain iron accumulation (NBIA) harboring a novel frameshift mutation in C19orf12 gene.	Iron	116-120	chromosome 19 open reading frame 12	Homo sapiens	182-190
11053410-10	2001	Together, these data indicate that the reaction of wild-type human Mb and NO yields either heme-NO or a novel S-nitrosated protein dependent on the oxidation state of the heme iron and the presence or absence of dioxygen.	Iron	176-180	myoglobin	Homo sapiens	67-69
33068888-1	2020	Mutations in an open-reading frame on chromosome 19 (C19orf12) were identified as one of the causative genes for neurodegeneration with brain iron accumulation (NBIA).	Iron	142-146	chromosome 19 open reading frame 12	Homo sapiens	53-61
33098868-0	2020	miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.	Iron	96-100	sirtuin 1	Homo sapiens	48-53
11221835-5	2001	The decrease in N-myc expression is iron-specific but does not result from inhibition of ribonucleotide reductase, because specific inhibition of this iron-containing enzyme by hydroxyurea does not affect N-myc protein levels.	Iron	36-40	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	16-21
32776106-2	2020	In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the secondary carrier, ISCA1, as the direct donors of Fe-S clusters to mitochondrial NFU1, which appears to dimerize and reductively mediate formation of a bridging [4Fe-4S] cluster, aided by ferredoxin 2 (FDX2).	Iron	185-187	iron-sulfur cluster assembly 1	Homo sapiens	154-159
33304466-0	2020	Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi.	Iron	59-63	Ccc1p	Saccharomyces cerevisiae S288C	39-43
11221835-5	2001	The decrease in N-myc expression is iron-specific but does not result from inhibition of ribonucleotide reductase, because specific inhibition of this iron-containing enzyme by hydroxyurea does not affect N-myc protein levels.	Iron	151-155	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	16-21
33304466-4	2020	In the case of fungi and plants, detoxification mainly occurs by importing cytosolic iron into the vacuole through the Ccc1/VIT1 iron transporter.	Iron	85-89	Ccc1p	Saccharomyces cerevisiae S288C	119-123
33304466-4	2020	In the case of fungi and plants, detoxification mainly occurs by importing cytosolic iron into the vacuole through the Ccc1/VIT1 iron transporter.	Iron	129-133	Ccc1p	Saccharomyces cerevisiae S288C	119-123
33304466-8	2020	Moreover, recent studies in the yeast Saccharomyces cerevisiae have also revealed that multiple transcription factors including Yap5 and Msn2/Msn4 contribute to the expression of CCC1 in high-iron conditions.	Iron	192-196	Ccc1p	Saccharomyces cerevisiae S288C	179-183
11206572-1	2001	Infrared spectra of the metastable state I (MSI) of normal and 15NO, N18O and 54Fe isotopically substituted sodium nitroprusside dihydrate (Na2[Fe(CN)5NO].2H2O) have been obtained at 77 K. A comparison of the isotopic shifts measured for the vibrational modes of the FeXY (XY = NO or ON) moiety with those calculated by means of quantum chemistry (DFT) procedures supports the linear Fe-O = N arrangement for the MSI state.	Iron	80-82	RB binding protein 4, chromatin remodeling factor	Homo sapiens	44-47
33304466-9	2020	Interestingly, Malaysian S. cerevisiae strains express a partially functional Ccc1 protein that renders them sensitive to iron.	Iron	122-126	Ccc1p	Saccharomyces cerevisiae S288C	78-82
11328568-0	2001	Expression of CD2 and activation markers on blood T-helper cell subsets in patients with transfusional iron overload.	Iron	103-107	CD2 molecule	Homo sapiens	14-17
32861780-1	2020	Hepcidin deficiency leads to iron overload by increased dietary iron uptake and iron release from storage cells.	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	0-8
32861780-1	2020	Hepcidin deficiency leads to iron overload by increased dietary iron uptake and iron release from storage cells.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	0-8
32861780-1	2020	Hepcidin deficiency leads to iron overload by increased dietary iron uptake and iron release from storage cells.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	0-8
32861780-2	2020	The most frequent mutation in Hfe leads to reduced hepcidin expression and thereby causes iron overload.	Iron	90-94	homeostatic iron regulator	Mus musculus	30-33
11328568-4	2001	When investigating whether this difference could be due to the iron overload we found the number of CD2 BS closely related to the iron saturation of serum transferrin (TfS) (R2 = 0.78, P &lt; 0.001).	Iron	63-67	CD2 molecule	Homo sapiens	100-103
32861780-2	2020	The most frequent mutation in Hfe leads to reduced hepcidin expression and thereby causes iron overload.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	51-59
32861780-7	2020	HFE protein levels were increased in Alk3fl/fl;Alb-Cre mice compared to Alk3fl/fl mice, which was caused by iron overload - and not by Alk3 deficiency.	Iron	108-112	homeostatic iron regulator	Mus musculus	0-3
32861780-7	2020	HFE protein levels were increased in Alk3fl/fl;Alb-Cre mice compared to Alk3fl/fl mice, which was caused by iron overload - and not by Alk3 deficiency.	Iron	108-112	bone morphogenetic protein receptor, type 1A	Mus musculus	37-41
11328568-4	2001	When investigating whether this difference could be due to the iron overload we found the number of CD2 BS closely related to the iron saturation of serum transferrin (TfS) (R2 = 0.78, P &lt; 0.001).	Iron	130-134	CD2 molecule	Homo sapiens	100-103
11201743-6	2001	Here we show that ys1 is a membrane protein that mediates iron uptake.	Iron	58-62	iron-phytosiderophore transporter yellow stripe 1	Zea mays	18-21
33156628-3	2020	Here we demonstrate by density functional theory calculations that precise spin manipulation can be achieved by extra CO and NO molecules coordination to transition metal phthalocyanine (TMPc) (TM = Co, Fe, Mn) molecules deposited on metal-supported graphene; the spins of TMPc molecules are switched from S to S - 1/2 ( S - 1 ) after NO (CO) coordination.	Iron	203-205	spindlin 1	Homo sapiens	75-79
11201743-7	2001	Expression of YS1 in a yeast iron uptake mutant restores growth specifically on Fe(III)-phytosiderophore media.	Iron	29-33	iron-phytosiderophore transporter yellow stripe 1	Zea mays	14-17
32557994-5	2020	Furthermore, we establish that the reaction order continues with 2-5$$-carbocyclization and 4$$-epimerization by the non-heme iron and 2-oxoglutarate-dependent enzymes SnoK and SnoN, respectively.	Iron	126-130	SKI like proto-oncogene	Homo sapiens	177-181
11201743-8	2001	Under iron-deficient conditions, ys1 messenger RNA levels increase in both roots and shoots.	Iron	6-10	iron-phytosiderophore transporter yellow stripe 1	Zea mays	33-36
32652459-1	2020	Glyceronephosphate O-acyltransferase (GNPAT) p.D519G (rs11558492) was identified as a genetic modifier correlated with more severe iron overload in hemochromatosis through whole-exome sequencing of HFE p.C282Y homozygotes with extreme iron phenotypes.	Iron	131-135	glyceronephosphate O-acyltransferase	Homo sapiens	0-36
11201743-9	2001	Cloning of ys1 is an important step in understanding iron uptake in grasses, and has implications for mechanisms controlling iron homeostasis in all plants.	Iron	53-57	iron-phytosiderophore transporter yellow stripe 1	Zea mays	11-14
32652459-1	2020	Glyceronephosphate O-acyltransferase (GNPAT) p.D519G (rs11558492) was identified as a genetic modifier correlated with more severe iron overload in hemochromatosis through whole-exome sequencing of HFE p.C282Y homozygotes with extreme iron phenotypes.	Iron	131-135	glyceronephosphate O-acyltransferase	Homo sapiens	38-43
32652459-1	2020	Glyceronephosphate O-acyltransferase (GNPAT) p.D519G (rs11558492) was identified as a genetic modifier correlated with more severe iron overload in hemochromatosis through whole-exome sequencing of HFE p.C282Y homozygotes with extreme iron phenotypes.	Iron	235-239	glyceronephosphate O-acyltransferase	Homo sapiens	0-36
32652459-1	2020	Glyceronephosphate O-acyltransferase (GNPAT) p.D519G (rs11558492) was identified as a genetic modifier correlated with more severe iron overload in hemochromatosis through whole-exome sequencing of HFE p.C282Y homozygotes with extreme iron phenotypes.	Iron	235-239	glyceronephosphate O-acyltransferase	Homo sapiens	38-43
11201743-9	2001	Cloning of ys1 is an important step in understanding iron uptake in grasses, and has implications for mechanisms controlling iron homeostasis in all plants.	Iron	125-129	iron-phytosiderophore transporter yellow stripe 1	Zea mays	11-14
33193643-4	2020	Most patients with PKD must receive regular transfusions in early childhood and as a consequence suffer from iron overloading.	Iron	109-113	protein kinase D1	Homo sapiens	19-22
33193643-10	2020	Conclusion: The lack of iron overload despite a reduced level of hepcidin in two transfusion-dependent PKD patients suggests the existence of a hepcidin-independent mechanism of iron regulation preventing iron overloading.	Iron	178-182	protein kinase D1	Homo sapiens	103-106
11358390-17	2001	Finally, we also tested for this TFR2 mutation 20 H63D homozygotes with milder manifestations of iron overload and no acquired cause of iron overload.	Iron	97-101	transferrin receptor 2	Homo sapiens	33-37
33193643-10	2020	Conclusion: The lack of iron overload despite a reduced level of hepcidin in two transfusion-dependent PKD patients suggests the existence of a hepcidin-independent mechanism of iron regulation preventing iron overloading.	Iron	178-182	protein kinase D1	Homo sapiens	103-106
11139594-5	2001	Our results suggest that iron particles induced an increase in lacZ MF (2.4-fold increase in p53+/+ mice, 1.3-fold increase in p53+/- mice and 2.1-fold increase in p53-/- mice) and that this induction is both temporally regulated and p53 genotype dependent.	Iron	25-29	transformation related protein 53, pseudogene	Mus musculus	93-96
33121166-8	2020	Moreover, iron markedly increased EMT and MMP-2/-9 expression in endometriotic lesions in an endometriosis mouse model.	Iron	10-14	matrix metallopeptidase 2	Mus musculus	42-50
33110073-7	2020	Mechanistically, neutrophils induce iron-dependent accumulation of lipid peroxides within tumor cells by transferring myeloperoxidase-containing granules into tumor cells.	Iron	36-40	myeloperoxidase	Mus musculus	118-133
11139594-5	2001	Our results suggest that iron particles induced an increase in lacZ MF (2.4-fold increase in p53+/+ mice, 1.3-fold increase in p53+/- mice and 2.1-fold increase in p53-/- mice) and that this induction is both temporally regulated and p53 genotype dependent.	Iron	25-29	transformation related protein 53, pseudogene	Mus musculus	127-130
11139594-5	2001	Our results suggest that iron particles induced an increase in lacZ MF (2.4-fold increase in p53+/+ mice, 1.3-fold increase in p53+/- mice and 2.1-fold increase in p53-/- mice) and that this induction is both temporally regulated and p53 genotype dependent.	Iron	25-29	transformation related protein 53, pseudogene	Mus musculus	127-130
11139594-5	2001	Our results suggest that iron particles induced an increase in lacZ MF (2.4-fold increase in p53+/+ mice, 1.3-fold increase in p53+/- mice and 2.1-fold increase in p53-/- mice) and that this induction is both temporally regulated and p53 genotype dependent.	Iron	25-29	transformation related protein 53, pseudogene	Mus musculus	127-130
11333118-10	2001	This notion was further supported by the finding that endocytosis of apoferritin, added to the medium, stabilized lysosomes (P &lt;0.001 versus P &lt;0.01) and increased survival (P &lt;0.01 versus P &lt;0.05) of iron-loaded A549 and BEAS-2B cells.	Iron	213-217	ferritin heavy chain 1	Homo sapiens	69-80
33113819-0	2020	Maternal Compliance to Recommended Iron and Folic Acid Supplementation in Pregnancy, Sri Lanka: A Hospital-Based Cross-Sectional Study.	Iron	35-39	sorcin	Homo sapiens	85-88
32811647-5	2020	Mass spectrometry analysis further showed that lactotransferrin (LTF), an iron-binding transport protein, is a direct NEDD4L-binding protein.	Iron	74-78	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	118-124
32811647-6	2020	Consequently, NEDD4L-mediated LTF protein degradation inhibits intracellular iron accumulation and subsequent oxidative damage-mediated ferroptotic cell death in various cancer cells.	Iron	77-81	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	14-20
11333118-11	2001	Assuming that primary cell lines of the alveolar and bronchial epithelium behave in a similar manner as these respiratory cell lines, intrabronchial instillation of apoferritin-containing liposomes may in the future be a treatment for iron-dependent airway inflammatory processes.	Iron	235-239	ferritin heavy chain 1	Homo sapiens	165-176
33192549-11	2020	Moreover, USP22, SIRT1, or SLC7A11 elevation contributed to enhanced cardiomyocyte viability and attenuated ferroptosis-induced cell death in vitro, accompanied by increased GSH levels, as well as decreased reactive oxygen species production, lipid peroxidation, and iron accumulation.	Iron	267-271	ubiquitin specific peptidase 22	Rattus norvegicus	10-15
11141352-9	2001	Hepatic myeloperoxidase activity increased by 1.1-, 2.1-, or 6.7-fold by lindane, iron, or their combined administration, respectively.	Iron	82-86	myeloperoxidase	Rattus norvegicus	8-23
33065981-0	2020	Macrophage-Derived Iron-Bound Lipocalin-2 Correlates with Renal Recovery Markers Following Sepsis-Induced Kidney Damage.	Iron	19-23	lipocalin 2	Homo sapiens	30-41
33065981-3	2020	Taking into account that Lcn-2 binds and transports iron with high affinity, we aimed at clarifying if Lcn-2 fulfills different biological functions according to its iron-loading status and its cellular source during sepsis-induced kidney failure.	Iron	52-56	lipocalin 2	Homo sapiens	25-30
33065981-3	2020	Taking into account that Lcn-2 binds and transports iron with high affinity, we aimed at clarifying if Lcn-2 fulfills different biological functions according to its iron-loading status and its cellular source during sepsis-induced kidney failure.	Iron	166-170	lipocalin 2	Homo sapiens	103-108
11368328-5	2000	In the absence of acetone, uroporphyrin accumulated in Cyp2e1(-/-) mice treated with Fe and ALA, but less than in wildtype mice.	Iron	85-87	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	55-61
33050207-7	2020	Surprisingly, while the dynasore targets dynamin 1 and 2 promote extracellular iron uptake, their silencing was not sufficient to block ferroptosis suggesting that this route of extracellular iron uptake is dispensable for acute induction of ferroptosis and dynasore must have an additional off-target activity mediating full ferroptosis protection.	Iron	79-83	dynamin 1	Homo sapiens	41-56
33049978-7	2020	Atheromas of Ldlr-/-LmnaG609G/G609G mice had features of unstable plaques, including the presence of erythrocytes and iron deposits and reduced smooth muscle cell and collagen content.	Iron	118-122	low density lipoprotein receptor	Mus musculus	13-17
33023155-0	2020	Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence.	Iron	22-26	PTEN induced kinase 1	Homo sapiens	135-140
33023155-2	2020	In patients suffering from Parkinson"s disease (PD), PINK1-PRKN mutations via deficient mitophagy trigger iron accumulation and reduce lifespan.	Iron	106-110	PTEN induced kinase 1	Homo sapiens	53-58
33023155-4	2020	In mouse cells, iron shortage decreased protein abundance for iron-binding nucleotide metabolism enzymes (prominently XDH and ferritin homolog RRM2).	Iron	16-20	xanthine dehydrogenase	Mus musculus	118-121
33023155-4	2020	In mouse cells, iron shortage decreased protein abundance for iron-binding nucleotide metabolism enzymes (prominently XDH and ferritin homolog RRM2).	Iron	16-20	ribonucleotide reductase M2	Mus musculus	143-147
33023155-4	2020	In mouse cells, iron shortage decreased protein abundance for iron-binding nucleotide metabolism enzymes (prominently XDH and ferritin homolog RRM2).	Iron	62-66	xanthine dehydrogenase	Mus musculus	118-121
33023155-4	2020	In mouse cells, iron shortage decreased protein abundance for iron-binding nucleotide metabolism enzymes (prominently XDH and ferritin homolog RRM2).	Iron	62-66	ribonucleotide reductase M2	Mus musculus	143-147
33023155-7	2020	Incidentally, upregulated Pink1-Prkn levels explained mitophagy induction, the downregulated expression of Slc25a28 suggested it to function in iron export.	Iron	144-148	solute carrier family 25 member 28	Homo sapiens	107-115
11076887-4	2000	Our inability to resolve the patient"s iron overload by regular phlebotomy is consistent with recent animal studies indicating an essential role for ceruloplasmin in cellular iron efflux.	Iron	175-179	ceruloplasmin	Homo sapiens	149-162
33023155-8	2020	The impact of PINK1 mutations in mouse and patient cells was pronounced only after iron overload, causing hyperreactive expression of ribosomal surveillance factor Abce1 and of ferritin, despite ferritin translation being repressed by IRP1.	Iron	83-87	ATP binding cassette subfamily E member 1	Homo sapiens	164-169
32485269-1	2020	We recently reported that loss of calcium/calmodulin-dependent protein kinase kinase-2 (CAMKK2), a serine/threonine kinase activated by intracellular calcium, in mice leads to tissue-specific aberrant turnover of transferrin (TF), a receptor-mediated iron-transporter that supplies iron to tissues.	Iron	251-255	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	34-86
32485269-1	2020	We recently reported that loss of calcium/calmodulin-dependent protein kinase kinase-2 (CAMKK2), a serine/threonine kinase activated by intracellular calcium, in mice leads to tissue-specific aberrant turnover of transferrin (TF), a receptor-mediated iron-transporter that supplies iron to tissues.	Iron	251-255	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	88-94
32485269-1	2020	We recently reported that loss of calcium/calmodulin-dependent protein kinase kinase-2 (CAMKK2), a serine/threonine kinase activated by intracellular calcium, in mice leads to tissue-specific aberrant turnover of transferrin (TF), a receptor-mediated iron-transporter that supplies iron to tissues.	Iron	251-255	transferrin	Mus musculus	213-224
11128746-2	2000	Although the synthesis of iron-free ferritin (apoferritin) provides antioxidant protection, the secretion of iron-containing ferritin by AMs could increase the availability of catalytic iron in the lungs.	Iron	26-30	ferritin heavy chain 1	Homo sapiens	46-57
32565019-5	2020	We examined the effect of deleting Pex13 in mouse liver on systemic iron homeostasis.	Iron	68-72	peroxisomal biogenesis factor 13	Mus musculus	35-40
32565019-7	2020	We demonstrate that transgenic mice lacking hepatocyte Pex13 have defects in systemic iron homeostasis.	Iron	86-90	peroxisomal biogenesis factor 13	Mus musculus	55-60
10942769-0	2000	Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	0-7
32470741-1	2020	When the nanoscale zero valent iron (nZVI) is used for the reduction of hexavalent chromium (Cr6+) to trivalent chromium (Cr3+) in groundwater, the reduction efficiency is decreased due to the passivation of reactive sites by precipitation.	Iron	31-35	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	93-96
32470741-6	2020	The pseudo-first-order kinetic model could be used to describe the Cr6+ adsorption mechanism by Fe/Al BNPs.	Iron	96-98	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	67-70
32470741-7	2020	Results show that Fe/Al BNPs and Al/Fe BNPs could reduce Cr6+ to Cr3+, and the removal efficiencies for Cr6+ were 1.47 g/g BNP and 0.07 g/g BNP, respectively.	Iron	18-20	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	57-60
10942769-0	2000	Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	9-13
32215701-0	2020	Sharp rises in FGF23 and hypophosphatemia after intravenous iron administration do not cause myocardial damage.	Iron	60-64	fibroblast growth factor 23	Homo sapiens	15-20
10942769-0	2000	Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	14-18
32707154-7	2020	Further investigations revealed that overexpression of hepcidin in astrocytes significantly reduced iron levels in cortex and hippocampus of APP/PS1 mice, especially iron content in neurons, which led to the reduction of iron accumulation-induced oxidative stress and neuroinflammation, and finally decreased neuronal cell death in the cortex and hippocampus of APP/PS1 mice.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	55-63
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	0-6
32707154-7	2020	Further investigations revealed that overexpression of hepcidin in astrocytes significantly reduced iron levels in cortex and hippocampus of APP/PS1 mice, especially iron content in neurons, which led to the reduction of iron accumulation-induced oxidative stress and neuroinflammation, and finally decreased neuronal cell death in the cortex and hippocampus of APP/PS1 mice.	Iron	166-170	hepcidin antimicrobial peptide	Mus musculus	55-63
32707154-7	2020	Further investigations revealed that overexpression of hepcidin in astrocytes significantly reduced iron levels in cortex and hippocampus of APP/PS1 mice, especially iron content in neurons, which led to the reduction of iron accumulation-induced oxidative stress and neuroinflammation, and finally decreased neuronal cell death in the cortex and hippocampus of APP/PS1 mice.	Iron	166-170	hepcidin antimicrobial peptide	Mus musculus	55-63
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	22-26
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	31-35
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	135-139	solute carrier family 11 member 2	Homo sapiens	0-6
32974842-2	2020	Clinical manifestations of PKD reflect the symptoms and complications of the chronic hemolysis, including anemia, jaundice, bilirubin gallstones due to hyperbilirubinemia, splenomegaly and iron overload.	Iron	189-193	protein kinase D1	Homo sapiens	27-30
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	135-139	solute carrier family 11 member 2	Homo sapiens	22-26
10942769-1	2000	Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	135-139	solute carrier family 11 member 2	Homo sapiens	31-35
10942769-7	2000	Iron transport at the plasma membrane was time- and pH-dependent, saturable, and proportional to the amount of Nramp2 expression.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	111-117
32747755-0	2020	CD44 regulates epigenetic plasticity by mediating iron endocytosis.	Iron	50-54	CD44 molecule (Indian blood group)	Homo sapiens	0-4
10942769-8	2000	Iron uptake by Nramp2 at the plasma membrane was into the nonferritin-bound, calcein-accessible so-called "labile iron pool."	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	15-21
32747755-3	2020	Here we report the discovery that CD44 mediates the endocytosis of iron-bound hyaluronates in tumorigenic cell lines, primary cancer cells and tumours.	Iron	67-71	CD44 molecule (Indian blood group)	Homo sapiens	34-38
32747755-5	2020	CD44 itself is transcriptionally regulated by nuclear iron through a positive feedback loop, which is in contrast to the negative regulation of the transferrin receptor by excess iron.	Iron	54-58	CD44 molecule (Indian blood group)	Homo sapiens	0-4
10942769-8	2000	Iron uptake by Nramp2 at the plasma membrane was into the nonferritin-bound, calcein-accessible so-called "labile iron pool."	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	15-21
32747755-5	2020	CD44 itself is transcriptionally regulated by nuclear iron through a positive feedback loop, which is in contrast to the negative regulation of the transferrin receptor by excess iron.	Iron	179-183	CD44 molecule (Indian blood group)	Homo sapiens	0-4
10942769-11	2000	Monitoring the effect of Nramp2 on the calcein-sensisitve labile iron pool allows a simple, rapid, and nonisotopic approach to the functional study of this protein.	Iron	65-69	solute carrier family 11 member 2	Homo sapiens	25-31
11045680-0	2000	Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies.	Iron	71-75	synuclein alpha	Homo sapiens	0-15
32988521-5	2020	Moreover, the addition of phytase linearly increased (P < 0.05) dietary protein, Ca, and phosphorus (P) utilization as well as nitrogen output, and excreta iron, copper, manganese, and zinc concentration quadratically increased (P < 0.05) as well as P output.	Iron	156-160	putative glycerophosphoryl diester phosphodiesterase	Glycine max	26-33
11050011-0	2000	Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation.	Iron	131-135	ATP binding cassette subfamily B member 7	Homo sapiens	6-10
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	ferritin light chain	Homo sapiens	190-193
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	dynamin 1	Homo sapiens	195-199
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	dynamin 1	Homo sapiens	277-281
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	syntaxin 3	Homo sapiens	283-287
33007950-6	2020	Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24).	Iron	173-177	bridging integrator 2	Homo sapiens	293-297
11050011-1	2000	The human protein ABC7 belongs to the adenosine triphosphate-binding cassette transporter superfamily, and its yeast orthologue, Atm1p, plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.	Iron	201-203	ATP binding cassette subfamily B member 7	Homo sapiens	18-22
32862644-2	2020	To solve these issues, the earth-abundant iron catalyst is employed, where Fe species are effectively modulated by siliceous zeolite, which is realized by the syn-thesis of Fe-containing MFI siliceous zeolite in the presence of ethylenediaminetetraacetic sodium (FeS-1-EDTA).	Iron	42-46	synemin	Homo sapiens	159-162
32862644-2	2020	To solve these issues, the earth-abundant iron catalyst is employed, where Fe species are effectively modulated by siliceous zeolite, which is realized by the syn-thesis of Fe-containing MFI siliceous zeolite in the presence of ethylenediaminetetraacetic sodium (FeS-1-EDTA).	Iron	75-77	synemin	Homo sapiens	159-162
10997923-9	2000	We also demonstrate that, in LLC-PK(1) cells exposed to nitric oxide donors, chelatable iron is involved in eliciting the HO-1 response observed at lower concentrations of these donors, and in mediating the cytotoxic effects of these donors when present in higher concentrations.	Iron	88-92	heme oxygenase 1	Homo sapiens	122-126
32862644-2	2020	To solve these issues, the earth-abundant iron catalyst is employed, where Fe species are effectively modulated by siliceous zeolite, which is realized by the syn-thesis of Fe-containing MFI siliceous zeolite in the presence of ethylenediaminetetraacetic sodium (FeS-1-EDTA).	Iron	173-175	synemin	Homo sapiens	159-162
32931417-0	2020	Preliminary assessment of the new Sysmex XN parameter Iron-Def for identifying iron deficiency.	Iron	54-58	UTP25 small subunit processome component	Homo sapiens	59-62
10971218-1	2000	Lactoferrin is a cationic iron-binding protein, which is released from activated neutrophils in concert with reactive oxygen species.	Iron	26-30	lactotransferrin	Rattus norvegicus	0-11
32931417-3	2020	(Iron-Def) parameter for identifying patients with iron deficiency.	Iron	1-5	UTP25 small subunit processome component	Homo sapiens	6-9
32931417-6	2020	RESULTS: A significant negative correlation was found between Sysmex XN Iron-Def and ferritin, serum iron, mean cell haemoglobin concentration, mean cell haemoglobin, mean corpuscular volume and age, while a positive correlation was noted with transferrin, percentage of microcytic red cell, red blood cell count and red blood cell distribution width.	Iron	72-76	UTP25 small subunit processome component	Homo sapiens	77-80
32931417-7	2020	The diagnostic accuracy of Iron-Def for identifying patients with a percentage of saturation of transferrin <15% (n=104) was 84%, with a sensitivity of 0.952 and specificity of 0.538.	Iron	27-31	UTP25 small subunit processome component	Homo sapiens	32-35
32931417-9	2020	DISCUSSION: Although additional confirmatory investigations would be needed, the preliminary findings of our study attest that Iron-Def may be an easy, inexpensive, rapid and reliable parameter for screening iron deficiency anaemia.	Iron	127-131	UTP25 small subunit processome component	Homo sapiens	132-135
10971218-2	2000	In vitro, lactoferrin has both anti- and proinflammatory effects; many of them dependent on iron-binding.	Iron	92-96	lactotransferrin	Rattus norvegicus	10-21
32971969-5	2020	Mice supplemented with Fe or EPA/DHA had lower soluble transferrin receptor, ferritin and hepcidin than controls, but these effects were attenuated in Fe+EPA/DHA mice.	Iron	23-25	hepcidin antimicrobial peptide	Mus musculus	90-98
10971218-3	2000	In vivo, only iron-free lactoferrin reduced inflammatory hyperpermeability in the lung.	Iron	14-18	lactotransferrin	Rattus norvegicus	24-35
10971218-10	2000	Iron-free lactoferrin and aLf alone did not change CBSA significantly.	Iron	0-4	lactotransferrin	Rattus norvegicus	10-21
10971218-11	2000	Iron-saturated lactoferrin significantly increased CBSA in skin (neck), trachea and left ventricle of the heart to 249 +/- 9, 284 +/- 16 and 160 +/- 7% of control, respectively.	Iron	0-4	lactotransferrin	Rattus norvegicus	15-26
10970442-5	2000	Hepatic iron, CYP1A activity and CYP1A1/1A2 protein were elevated &gt;20-fold as a result of iron or Aroclor treatments, respectively, but porphyria with associated histological changes only developed in the combined iron/Aroclor treatment group.	Iron	93-97	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-39
32882128-1	2020	A family of iron(III) spin crossover complexes with different counteranions, [Fe(qsal-F)2]A (qsal-F = 4-fluoro-2-[(8-quinolylimino)methyl]phenolate; A = PF6- 1, OTf- 2, NO3- 3, ClO4- 4, BF4- 5, or NCS- 6) have been prepared.	Iron	12-16	spindlin 1	Homo sapiens	22-26
10970442-5	2000	Hepatic iron, CYP1A activity and CYP1A1/1A2 protein were elevated &gt;20-fold as a result of iron or Aroclor treatments, respectively, but porphyria with associated histological changes only developed in the combined iron/Aroclor treatment group.	Iron	93-97	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-39
32917022-1	2020	In plants, the cysteine desulfurase (AtNFS1) and frataxin (AtFH) are involved in the formation of Fe-S groups in mitochondria, specifically, in Fe and sulfur loading onto scaffold proteins, and the subsequent formation of the mature Fe-S cluster.	Iron	98-100	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	37-43
10984552-1	2000	The recent discovery of HFE, the MHC-Class-I-like gene mutated in up to 90% of patients with hereditary haemochromatosis, and the gene encoding the Nramp2/divalent metal transporter-1 (DMT-1) implicated in ferrous iron transport holds promise for a greater understanding of human iron metabolism.	Iron	214-218	solute carrier family 11 member 2	Homo sapiens	148-183
32917022-1	2020	In plants, the cysteine desulfurase (AtNFS1) and frataxin (AtFH) are involved in the formation of Fe-S groups in mitochondria, specifically, in Fe and sulfur loading onto scaffold proteins, and the subsequent formation of the mature Fe-S cluster.	Iron	144-146	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	37-43
32917022-1	2020	In plants, the cysteine desulfurase (AtNFS1) and frataxin (AtFH) are involved in the formation of Fe-S groups in mitochondria, specifically, in Fe and sulfur loading onto scaffold proteins, and the subsequent formation of the mature Fe-S cluster.	Iron	144-146	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	37-43
32917022-5	2020	Our results suggest that AtFH, AtNFS1 and AtISD11 form a multiprotein complex that could be involved in different stages of the iron-sulfur cluster (ISC) pathway in plant mitochondria.	Iron	128-132	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	31-37
10984552-1	2000	The recent discovery of HFE, the MHC-Class-I-like gene mutated in up to 90% of patients with hereditary haemochromatosis, and the gene encoding the Nramp2/divalent metal transporter-1 (DMT-1) implicated in ferrous iron transport holds promise for a greater understanding of human iron metabolism.	Iron	214-218	solute carrier family 11 member 2	Homo sapiens	185-190
10984552-1	2000	The recent discovery of HFE, the MHC-Class-I-like gene mutated in up to 90% of patients with hereditary haemochromatosis, and the gene encoding the Nramp2/divalent metal transporter-1 (DMT-1) implicated in ferrous iron transport holds promise for a greater understanding of human iron metabolism.	Iron	280-284	solute carrier family 11 member 2	Homo sapiens	148-183
10984552-1	2000	The recent discovery of HFE, the MHC-Class-I-like gene mutated in up to 90% of patients with hereditary haemochromatosis, and the gene encoding the Nramp2/divalent metal transporter-1 (DMT-1) implicated in ferrous iron transport holds promise for a greater understanding of human iron metabolism.	Iron	280-284	solute carrier family 11 member 2	Homo sapiens	185-190
33015091-2	2020	Clinical studies suggest that several proteins related to iron metabolism, including transferrin, serve as urinary biomarkers of lupus nephritis.	Iron	58-62	transferrin	Mus musculus	85-96
33015091-9	2020	Together, these data show that increased urinary transferrin excretion and renal tissue iron accumulation also occurs in albuminuric male MRL/lpr mice, suggesting that renal iron accumulation may be a feature of multiple mouse models of SLE.	Iron	174-178	transferrin	Mus musculus	49-60
10984552-5	2000	Immunohistochemical staining showed that DMT-1 protein localized to the brush border of human duodenum where it is predicted to serve as the principal transporter of ferrous iron from the intestinal lumen.	Iron	174-178	solute carrier family 11 member 2	Homo sapiens	41-46
10984552-7	2000	This interaction may be critical in small-intestinal crypt cells which express HFE, where it may function to modulate their intrinsic iron status thereby programming iron absorption by DMT-1 in the mature enterocyte.	Iron	166-170	solute carrier family 11 member 2	Homo sapiens	185-190
10984552-8	2000	In undifferentiated Caco-2 cells, DMT-1 localized to a discrete late endosome compartment distinct from that occupied by HFE where, in addition to brush-border iron uptake, it may function to regulate the availability of iron delivery to intracellular iron pools.	Iron	160-164	solute carrier family 11 member 2	Homo sapiens	34-39
10984552-8	2000	In undifferentiated Caco-2 cells, DMT-1 localized to a discrete late endosome compartment distinct from that occupied by HFE where, in addition to brush-border iron uptake, it may function to regulate the availability of iron delivery to intracellular iron pools.	Iron	221-225	solute carrier family 11 member 2	Homo sapiens	34-39
32787335-0	2020	Key Role of the Surface Band Structure in Spin-Dependent Interfacial Electron Transfer: Ar/Fe(110) and Ar/Co(0001).	Iron	91-93	spindlin 1	Homo sapiens	42-46
10984552-8	2000	In undifferentiated Caco-2 cells, DMT-1 localized to a discrete late endosome compartment distinct from that occupied by HFE where, in addition to brush-border iron uptake, it may function to regulate the availability of iron delivery to intracellular iron pools.	Iron	221-225	solute carrier family 11 member 2	Homo sapiens	34-39
10984552-10	2000	Identification of the molecular interactions of HFE with DMT-1 and other key components of the iron transport pathway has implications for a mechanistic understanding of the pathophysiology of human iron storage diseases as well as the regulation of normal iron balance.	Iron	95-99	solute carrier family 11 member 2	Homo sapiens	57-62
10984552-10	2000	Identification of the molecular interactions of HFE with DMT-1 and other key components of the iron transport pathway has implications for a mechanistic understanding of the pathophysiology of human iron storage diseases as well as the regulation of normal iron balance.	Iron	199-203	solute carrier family 11 member 2	Homo sapiens	57-62
10984552-10	2000	Identification of the molecular interactions of HFE with DMT-1 and other key components of the iron transport pathway has implications for a mechanistic understanding of the pathophysiology of human iron storage diseases as well as the regulation of normal iron balance.	Iron	199-203	solute carrier family 11 member 2	Homo sapiens	57-62
31743298-9	2020	Increased pulmonary iron concentration not only facilitated bacterial growth but also led to the defective phagocytic function of lung macrophages via activation of RhoA GTPase through oxidation of RhoGDI.	Iron	20-24	Rho GDP dissociation inhibitor (GDI) alpha	Mus musculus	198-204
10766749-10	2000	Transcription of the cSHMT gene is also inhibited by deferoxamine in MCF-7 cells, indicating that mimosine inhibits cSHMT transcription by chelating iron.	Iron	149-153	serine hydroxymethyltransferase 1	Homo sapiens	21-26
32766721-0	2020	Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	13-21
10766749-10	2000	Transcription of the cSHMT gene is also inhibited by deferoxamine in MCF-7 cells, indicating that mimosine inhibits cSHMT transcription by chelating iron.	Iron	149-153	serine hydroxymethyltransferase 1	Homo sapiens	116-121
32766721-2	2020	Subjects with HFE (Homeostatic Iron Regulator) p.C282Y mutations and the GNPAT p.D519G variant had more iron loading compared to subjects without the GNPAT variant.	Iron	104-108	homeostatic iron regulator	Mus musculus	14-17
32766721-3	2020	In response to an oral iron challenge, women with GNPAT polymorphisms loaded more iron as compared to women without polymorphisms, reinforcing a role for GNPAT in iron homeostasis.	Iron	23-27	glyceronephosphate O-acyltransferase	Homo sapiens	50-55
10748212-7	2000	Maximum ferritin derepression was obtained with 50 microm iron citrate (1:10) or 500 microm iron citrate (1:1) but Fe-EDTA was ineffective, although the leaf iron concentration was increased; manganese, zinc, and copper had no effect.	Iron	58-62	ferritin-1, chloroplastic	Glycine max	8-16
32766721-3	2020	In response to an oral iron challenge, women with GNPAT polymorphisms loaded more iron as compared to women without polymorphisms, reinforcing a role for GNPAT in iron homeostasis.	Iron	23-27	glyceronephosphate O-acyltransferase	Homo sapiens	154-159
32766721-3	2020	In response to an oral iron challenge, women with GNPAT polymorphisms loaded more iron as compared to women without polymorphisms, reinforcing a role for GNPAT in iron homeostasis.	Iron	82-86	glyceronephosphate O-acyltransferase	Homo sapiens	50-55
32766721-3	2020	In response to an oral iron challenge, women with GNPAT polymorphisms loaded more iron as compared to women without polymorphisms, reinforcing a role for GNPAT in iron homeostasis.	Iron	82-86	glyceronephosphate O-acyltransferase	Homo sapiens	154-159
32766721-3	2020	In response to an oral iron challenge, women with GNPAT polymorphisms loaded more iron as compared to women without polymorphisms, reinforcing a role for GNPAT in iron homeostasis.	Iron	82-86	glyceronephosphate O-acyltransferase	Homo sapiens	50-55
32766721-3	2020	In response to an oral iron challenge, women with GNPAT polymorphisms loaded more iron as compared to women without polymorphisms, reinforcing a role for GNPAT in iron homeostasis.	Iron	82-86	glyceronephosphate O-acyltransferase	Homo sapiens	154-159
32766721-4	2020	The aim of this study was to develop and characterize an animal model of disease to further our understanding of genetic modifiers, and in particular, the role of GNPAT in iron homeostasis.	Iron	172-176	glyceronephosphate O-acyltransferase	Homo sapiens	163-168
32766721-8	2020	These results reinforce an independent role of GNPAT in systemic iron homeostasis, reproducing in an animal model the observations in women with GNPAT polymorphisms subjected to an iron tolerance test.	Iron	65-69	glyceronephosphate O-acyltransferase	Homo sapiens	47-52
32766721-8	2020	These results reinforce an independent role of GNPAT in systemic iron homeostasis, reproducing in an animal model the observations in women with GNPAT polymorphisms subjected to an iron tolerance test.	Iron	181-185	glyceronephosphate O-acyltransferase	Homo sapiens	47-52
32766721-8	2020	These results reinforce an independent role of GNPAT in systemic iron homeostasis, reproducing in an animal model the observations in women with GNPAT polymorphisms subjected to an iron tolerance test.	Iron	181-185	glyceronephosphate O-acyltransferase	Homo sapiens	145-150
10748212-8	2000	The basis for different responses in ferritin expression to different iron complexes, as well as the significance of using DNA but not mRNA as an iron regulatory target in plants, remain unknown.	Iron	70-74	ferritin-1, chloroplastic	Glycine max	37-45
32833964-7	2020	Loss of RAB7A, an endolysosomal marker and top suppressor in our genetic screen, blocked transferrin receptor degradation, restored iron homeostasis and reversed the growth defect as well as metabolic alterations due to VPS34 inhibition.	Iron	132-136	RAB7A, member RAS oncogene family	Homo sapiens	8-13
10748106-0	2000	Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo.	Iron	58-62	transferrin receptor 2	Homo sapiens	0-22
32833964-8	2020	Altogether, our findings suggest that impaired iron mobilization via the VPS34-RAB7A axis drive VPS34-dependence in certain cancer cells.	Iron	47-51	RAB7A, member RAS oncogene family	Homo sapiens	79-84
10781438-7	2000	Consequent to these increased concentrations of iron, proteins to store and transport iron, ferritin, and lactoferrin, respectively, were increased when assayed by immunoprecipitation and immunohistochemistry.	Iron	48-52	lactotransferrin	Mus musculus	106-117
32825437-8	2020	The adult male offspring of maternal rats fed low-iron diets before pregnancy, during pregnancy and throughout the lactation period had (1) spatial deficits, (2) a decreased BDNF mRNA expression and protein concentrations, accompanied by a decreased TrkB protein abundance, (3) a decreased plasma acetate concentration, and (4) an enrichment of the Bacteroidaceae genus Bacteroides and Lachnospiraceae genus Marvinbryantia.	Iron	50-54	brain-derived neurotrophic factor	Rattus norvegicus	174-178
32817691-5	2020	This includes structural genes involved in Fe uptake (i.e. IRT1, FRO2, PDR9, NRAMP1) and transport (i.e. FRD3, NAS4) as well as a subset of their upstream regulators, namely BTS, PYE and the four clade Ib bHLH.	Iron	43-45	iron-regulated transporter 1	Arabidopsis thaliana	59-63
10823667-8	2000	These data demonstrated that nitric oxide might be a mediator of iron chelating agents and hypoxic agents to inhibit dioxin induced Cyp1a1 promoter activity in Hepa I cells.	Iron	65-69	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
32817691-5	2020	This includes structural genes involved in Fe uptake (i.e. IRT1, FRO2, PDR9, NRAMP1) and transport (i.e. FRD3, NAS4) as well as a subset of their upstream regulators, namely BTS, PYE and the four clade Ib bHLH.	Iron	43-45	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	77-83
32463527-6	2020	A comprehensive bonding analysis of all 1 -Ae complexes using the QTAIM and EDA-NOCV methods shows that the heavier species 1 -Ca, 1 -Sr and 1 -Ba possess genuine Fe Ae bonds which involve vacant d -orbitals of the alkaline earth atoms and partially filled d -orbitals on Fe.	Iron	163-165	ALL1	Homo sapiens	36-41
10872745-5	2000	We had previously shown that inhibitors of HO-1 and the mitochondrial permeability transition pore (MTP) block the uptake of mitochondrial iron in astrocytes exposed to the pro-oxidant effects of dopamine and several pro-inflammatory cytokines.	Iron	139-143	heme oxygenase 1	Homo sapiens	43-47
32636300-8	2020	We observed decreased levels of Yfh1/frataxin, an essential component of the iron-sulfur biogenesis machinery, in mitochondria from TAZ-KO mouse cells and in CL-deleted yeast crd1Delta cells, indicating that the role of CL in iron-sulfur biogenesis is highly conserved.	Iron	226-230	ferroxidase	Saccharomyces cerevisiae S288C	32-36
10872745-7	2000	Thus, the marked enhancement of HO-1 expression previously demonstrated in AD-affected neurons and astroglia may transduce amyloid (oxidative) stress into the abnormal patterns of iron deposition and mitochondrial insufficiency characteristic of this disease.	Iron	180-184	heme oxygenase 1	Homo sapiens	32-36
32636300-8	2020	We observed decreased levels of Yfh1/frataxin, an essential component of the iron-sulfur biogenesis machinery, in mitochondria from TAZ-KO mouse cells and in CL-deleted yeast crd1Delta cells, indicating that the role of CL in iron-sulfur biogenesis is highly conserved.	Iron	226-230	frataxin	Mus musculus	37-45
10939630-0	2000	Retinol-induced elevation of ornithine decarboxylase activity in cultured rat Sertoli cells is attenuated by free radical scavenger and by iron chelator.	Iron	139-143	ornithine decarboxylase 1	Rattus norvegicus	29-52
32518166-10	2020	We conclude that Mfrn1 and Mfrn2 contribute to mitochondrial iron homeostasis and are required for high-affinity iron import during active proliferation of mammalian cells.	Iron	61-65	solute carrier family 25 member 37	Homo sapiens	17-22
10939630-6	2000	Retinol-induced ornithine decarboxylase activity was significantly decreased by addition of free radical scavenger (mannitol) or iron chelator (1,10 phenanthroline).	Iron	129-133	ornithine decarboxylase 1	Rattus norvegicus	16-39
32518166-10	2020	We conclude that Mfrn1 and Mfrn2 contribute to mitochondrial iron homeostasis and are required for high-affinity iron import during active proliferation of mammalian cells.	Iron	61-65	solute carrier family 25 member 28	Homo sapiens	27-32
10785640-1	2000	To obtain iron from the host for growth, staphylococci have evolved sophisticated iron-scavenging systems including siderophores and a cell surface receptor for transferrin, the mammalian iron-transporting glycoprotein.	Iron	10-14	CD177 molecule	Homo sapiens	135-156
32518166-10	2020	We conclude that Mfrn1 and Mfrn2 contribute to mitochondrial iron homeostasis and are required for high-affinity iron import during active proliferation of mammalian cells.	Iron	113-117	solute carrier family 25 member 37	Homo sapiens	17-22
32518166-10	2020	We conclude that Mfrn1 and Mfrn2 contribute to mitochondrial iron homeostasis and are required for high-affinity iron import during active proliferation of mammalian cells.	Iron	113-117	solute carrier family 25 member 28	Homo sapiens	27-32
10785640-1	2000	To obtain iron from the host for growth, staphylococci have evolved sophisticated iron-scavenging systems including siderophores and a cell surface receptor for transferrin, the mammalian iron-transporting glycoprotein.	Iron	82-86	CD177 molecule	Homo sapiens	135-156
10840964-0	2000	Elucidating the mode of action of a corrosion inhibitor for iron Two polymetallic iron(III) complexes 1 and 2 have been synthesised from the known corrosion inhibitor 3-(4-methylbenzoyl)-propionic acid HL1 and their crystal structures determined.	Iron	60-64	intelectin 1	Homo sapiens	202-205
32531201-4	2020	Ferritin heavy chain was identified as the critical secretory cargo, required for the protection against iron-mediated ferroptotic axonal damage.	Iron	105-109	ferritin heavy polypeptide 1	Mus musculus	0-20
32251724-2	2020	In response to iron deficiency, the Saccharomyces cerevisiae iron-responsive transcription factor Aft1 accumulates in the nucleus and activates a set of genes that promote iron acquisition at the cell surface.	Iron	15-19	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	98-102
32251724-2	2020	In response to iron deficiency, the Saccharomyces cerevisiae iron-responsive transcription factor Aft1 accumulates in the nucleus and activates a set of genes that promote iron acquisition at the cell surface.	Iron	61-65	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	98-102
10691965-0	2000	The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.	Iron	75-79	melanotransferrin	Homo sapiens	47-64
32251724-2	2020	In response to iron deficiency, the Saccharomyces cerevisiae iron-responsive transcription factor Aft1 accumulates in the nucleus and activates a set of genes that promote iron acquisition at the cell surface.	Iron	61-65	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	98-102
32430665-15	2020	CONCLUSIONS/INTERPRETATION: Deletion of macrophage H-ferritin suppresses the inflammatory response by reducing intracellular iron levels, resulting in the prevention of HFD-induced obesity and diabetes.	Iron	125-129	ferritin heavy polypeptide 1	Mus musculus	51-61
31601687-1	2020	Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis.	Iron	101-105	transferrin	Mus musculus	67-78
10691965-0	2000	The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.	Iron	75-79	melanotransferrin	Homo sapiens	66-69
31601687-7	2020	These findings provide direct evidence that Tfr1 is essential for hematopoiesis through binding diferric transferrin to supply iron to cells.	Iron	127-131	transferrin	Mus musculus	105-116
10691965-2	2000	MTf is found at high levels in melanoma cells and previous studies have shown that MTf can bind Fe.	Iron	96-98	melanotransferrin	Homo sapiens	0-3
31778583-1	2020	Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin.	Iron	118-122	hepcidin antimicrobial peptide	Mus musculus	131-139
10691965-2	2000	MTf is found at high levels in melanoma cells and previous studies have shown that MTf can bind Fe.	Iron	96-98	melanotransferrin	Homo sapiens	83-86
31778583-6	2020	Notably, dietary iron loading still induced liver SMAD5 phosphorylation and hepcidin in double Bmp6/endothelial Bmp2 KO mice, although no other BMP ligand mRNAs were increased in the livers of double KO mice, and only Bmp6 and Bmp2 mRNA were induced by dietary iron loading in wildtype mice.	Iron	17-21	hepcidin antimicrobial peptide	Mus musculus	76-84
10691965-3	2000	In addition, Chinese hamster ovary cells transfected with MTf transport Fe from 59Fe-citrate at greater rates than control cells.	Iron	72-74	melanotransferrin	Homo sapiens	58-61
31778583-7	2020	In contrast, double Hfe/endothelial Bmp2 KO mice exhibited reduced hepcidin and increased extrahepatic iron loading compared to single Hfe or endothelial Bmp2 KO mice.	Iron	103-107	homeostatic iron regulator	Mus musculus	20-23
10691965-5	2000	In the present study we have characterized the role of MTf in Fe uptake by SK-Mel-28 melanoma cells in order to understand its function.	Iron	62-64	melanotransferrin	Homo sapiens	55-58
10691965-6	2000	Initial studies examined whether modulation of intracellular Fe levels using the Fe chelator desferrioxamine (DFO) or the Fe donor ferric ammonium citrate (FAC) could change MTf mRNA levels.	Iron	61-63	melanotransferrin	Homo sapiens	174-177
32449967-8	2020	Hepcidin and ferroportin expressions were positively associated with placental non-heme iron reserve (P < 0.0001; P = 0.033), lipid peroxidation (P = 0.0060; P < 0.0001) and reactive oxygen species level (P = 0.0092; P = 0.0292).	Iron	88-92	hepcidin antimicrobial peptide	Sus scrofa	0-8
10691965-9	2000	Further studies examined the ability of DFO and FAC to modulate Fe uptake from 59Fe-citrate which is bound by MTf.	Iron	64-66	melanotransferrin	Homo sapiens	110-113
32449967-10	2020	This indicates hepcidin and ferroportin may have a role in controlling the local placental iron flux by acting as a molecular bridge between iron trafficking and inflammation.	Iron	91-95	hepcidin antimicrobial peptide	Sus scrofa	15-23
32449967-10	2020	This indicates hepcidin and ferroportin may have a role in controlling the local placental iron flux by acting as a molecular bridge between iron trafficking and inflammation.	Iron	141-145	hepcidin antimicrobial peptide	Sus scrofa	15-23
10691965-14	2000	These results suggest that MTf played only a minor role in Fe uptake from 59Fe-citrate by these cells.	Iron	59-61	melanotransferrin	Homo sapiens	27-30
10681454-4	2000	Recently a human cDNA highly homologous to TfR was identified and reported to encode a protein (TfR2) that binds holotransferrin and mediates uptake of transferrin-bound iron.	Iron	170-174	transferrin receptor 2	Homo sapiens	96-100
10660599-1	2000	Ceruloplasmin is a copper-containing ferroxidase that is essential for normal iron homeostasis.	Iron	78-82	ceruloplasmin	Homo sapiens	0-13
33102313-2	2020	Gamma glutamate transferase (GGT) and ferritin increase oxidant stress in the body through their role in glutathione homeostasis and iron metabolism, respectively.	Iron	133-137	gamma-glutamyltransferase 1	Homo sapiens	0-27
33102313-2	2020	Gamma glutamate transferase (GGT) and ferritin increase oxidant stress in the body through their role in glutathione homeostasis and iron metabolism, respectively.	Iron	133-137	gamma-glutamyltransferase 1	Homo sapiens	29-32
10660599-7	2000	Therefore, this novel GPI-anchored form of ceruloplasmin is likely to play an important role in iron metabolism in the central nervous system.	Iron	96-100	ceruloplasmin	Homo sapiens	43-56
32608971-2	2020	NCOA4 binds to ferritin and delivers it to nascent autophagosomes, which then merge with the lysosomes for ferritin degradation and iron release.	Iron	132-136	nuclear receptor coactivator 4	Homo sapiens	0-5
10652280-2	2000	In vitro studies on recombinant ferritin subunits have shown that the ferroxidase activity associated with the H subunit is necessary for iron uptake by the ferritin molecule, whereas the L subunit facilitates iron core formation inside the protein shell.	Iron	138-142	ceruloplasmin	Mus musculus	70-81
32608971-7	2020	Whereas the iron oxidation kinetics were not affected by the presence of NCOA4, iron mobilization from ferritin by two different reducing agents (FMN/NADH and sodium dithionite) showed a strong inhibition effect that was dependent on the concentration of NCOA4 present in solution.	Iron	80-84	nuclear receptor coactivator 4	Homo sapiens	255-260
32608971-8	2020	Our results suggest that NCOA4 binding to ferritin may interfere in the electron transfer pathway through the ferritin shell and may have important biological implications on cellular iron homeostasis.	Iron	184-188	nuclear receptor coactivator 4	Homo sapiens	25-30
10651644-2	2000	PDF represents a novel class of mononuclear iron protein, which utilizes an Fe(2+) ion to catalyze the hydrolysis of an amide bond.	Iron	44-48	peptide deformylase, mitochondrial	Homo sapiens	0-3
32668236-0	2020	Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3" UTR-Directed Regulation and Nonsense-Mediated Decay.	Iron	57-61	ATP binding cassette subfamily E member 1	Homo sapiens	22-27
32668236-4	2020	This pathway maintains the activity of the Fe-S cluster-containing ribosome recycling factor ABCE1, whose impaired function results in movement of ribosomes into 3" UTRs, where they displace exon junction complexes, abrogating NMD.	Iron	43-47	ATP binding cassette subfamily E member 1	Homo sapiens	93-98
32668236-6	2020	Because of the sensitivity of the Fe-S cluster of ABCE1 to iron availability and reactive oxygen species, these findings reveal an unanticipated vulnerability of 3" UTR-directed regulation to lysosomal dysfunction, iron deficiency, and oxidative stress.	Iron	34-36	ATP binding cassette subfamily E member 1	Homo sapiens	50-55
32668236-6	2020	Because of the sensitivity of the Fe-S cluster of ABCE1 to iron availability and reactive oxygen species, these findings reveal an unanticipated vulnerability of 3" UTR-directed regulation to lysosomal dysfunction, iron deficiency, and oxidative stress.	Iron	59-63	ATP binding cassette subfamily E member 1	Homo sapiens	50-55
32409586-2	2020	It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III).	Iron	110-114	STEAP4 metalloreductase	Homo sapiens	55-61
32409586-2	2020	It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III).	Iron	110-114	2,4-dienoyl-CoA reductase 1	Homo sapiens	81-86
32409586-7	2020	Enzymatic assays in human cells revealed that STEAP1 promotes iron(III) reduction when fused to the intracellular NADPH-binding domain of its family member STEAP4, suggesting that STEAP1 functions as a ferric reductase in STEAP heterotrimers.	Iron	62-66	2,4-dienoyl-CoA reductase 1	Homo sapiens	114-119
32409586-7	2020	Enzymatic assays in human cells revealed that STEAP1 promotes iron(III) reduction when fused to the intracellular NADPH-binding domain of its family member STEAP4, suggesting that STEAP1 functions as a ferric reductase in STEAP heterotrimers.	Iron	62-66	STEAP4 metalloreductase	Homo sapiens	156-162
10713971-7	2000	Increasing the iron binding capacity of the milk by 340 microM by targeting the lactoferrin transgene to the mammary gland did not alter the relation between milk iron and the serum iron:transferrin ratio.	Iron	15-19	lactotransferrin	Mus musculus	80-91
32647232-7	2020	Following AAV-mediated overexpression of alpha-synuclein protein associated with Parkinson"s disease, these granules shift towards higher Fe concentrations.	Iron	138-140	synuclein alpha	Rattus norvegicus	41-56
10655482-5	2000	Depletion of Yah1p by regulated gene expression resulted in a 30-fold accumulation of iron within mitochondria, similar to what has been reported for other components involved in Fe/S protein biogenesis.	Iron	86-90	adrenodoxin	Saccharomyces cerevisiae S288C	13-18
32414791-5	2020	Glrx3/hGMPs interact through conserved residues which bridge iron/sulphur clusters and glutathione.	Iron	61-65	guanine monophosphate synthase	Homo sapiens	6-11
32414791-10	2020	The molecular function of yeast glutaredoxins Grx3 and Grx4 has an enormous interest since both proteins are required to maintain a correct iron homeostasis and an efficient response to oxidative stress.	Iron	140-144	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	46-50
10644516-1	2000	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme catabolism and presumably is involved in cellular iron homeostasis.	Iron	115-119	heme oxygenase 1	Homo sapiens	0-16
10644516-1	2000	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme catabolism and presumably is involved in cellular iron homeostasis.	Iron	115-119	heme oxygenase 1	Homo sapiens	18-22
32147528-0	2020	The yeast Aft1 transcription factor activates ribonucleotide reductase catalytic subunit RNR1 in response to iron deficiency.	Iron	109-113	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	10-14
10842752-4	2000	In fact, in oxidative stress in vitro, HO-1 is protective (91-94) but within a narrow threshold of overexpression (93,94) in some models, since iron released in the HO reaction may obviate any cytoprotective effect (Fig.	Iron	144-148	heme oxygenase 1	Homo sapiens	39-43
32147528-0	2020	The yeast Aft1 transcription factor activates ribonucleotide reductase catalytic subunit RNR1 in response to iron deficiency.	Iron	109-113	ribonucleotide-diphosphate reductase subunit RNR1	Saccharomyces cerevisiae S288C	89-93
32147528-3	2020	Upon iron starvation, the Saccharomyces cerevisiae Aft1 transcription factor specifically binds to iron-responsive cis elements within the promoter of a group of genes, known as the iron regulon, activating their transcription.	Iron	5-9	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	51-55
32147528-3	2020	Upon iron starvation, the Saccharomyces cerevisiae Aft1 transcription factor specifically binds to iron-responsive cis elements within the promoter of a group of genes, known as the iron regulon, activating their transcription.	Iron	99-103	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	51-55
32147528-3	2020	Upon iron starvation, the Saccharomyces cerevisiae Aft1 transcription factor specifically binds to iron-responsive cis elements within the promoter of a group of genes, known as the iron regulon, activating their transcription.	Iron	99-103	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	51-55
32147528-6	2020	We demonstrate that Aft1 and the DNA-binding protein Ixr1 enhance the expression of the gene encoding for its catalytic subunit, RNR1, in response to iron limitation, leading to an increase in both mRNA and protein levels.	Iron	150-154	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	20-24
32147528-6	2020	We demonstrate that Aft1 and the DNA-binding protein Ixr1 enhance the expression of the gene encoding for its catalytic subunit, RNR1, in response to iron limitation, leading to an increase in both mRNA and protein levels.	Iron	150-154	ribonucleotide-diphosphate reductase subunit RNR1	Saccharomyces cerevisiae S288C	129-133
32147528-7	2020	By mutagenesis of the Aft1-binding sites within RNR1 promoter, we conclude that RNR1 activation by iron depletion is important for Rnr1 protein and deoxyribonucleotide synthesis.	Iron	99-103	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	22-26
10567692-2	1999	This work examines the role and regulation of GPD1 and GPD2, encoding two isoforms of glycerol 3-phosphate dehydrogenase, in glycerol production during iron starvation.	Iron	152-156	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	55-59
32147528-7	2020	By mutagenesis of the Aft1-binding sites within RNR1 promoter, we conclude that RNR1 activation by iron depletion is important for Rnr1 protein and deoxyribonucleotide synthesis.	Iron	99-103	ribonucleotide-diphosphate reductase subunit RNR1	Saccharomyces cerevisiae S288C	48-52
32147528-7	2020	By mutagenesis of the Aft1-binding sites within RNR1 promoter, we conclude that RNR1 activation by iron depletion is important for Rnr1 protein and deoxyribonucleotide synthesis.	Iron	99-103	ribonucleotide-diphosphate reductase subunit RNR1	Saccharomyces cerevisiae S288C	80-84
32147528-7	2020	By mutagenesis of the Aft1-binding sites within RNR1 promoter, we conclude that RNR1 activation by iron depletion is important for Rnr1 protein and deoxyribonucleotide synthesis.	Iron	99-103	ribonucleotide-diphosphate reductase subunit RNR1	Saccharomyces cerevisiae S288C	131-135
32147528-8	2020	Remarkably, Aft1 also activates the expression of IXR1 upon iron scarcity through an iron-responsive element located within its promoter.	Iron	60-64	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	12-16
32147528-8	2020	Remarkably, Aft1 also activates the expression of IXR1 upon iron scarcity through an iron-responsive element located within its promoter.	Iron	85-89	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	12-16
32147528-9	2020	These results provide a novel mechanism for the direct activation of ribonucleotide reductase function by the iron-regulated Aft1 transcription factor.	Iron	110-114	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	125-129
10567692-5	1999	Deletion of either GPD1 or GPD2 alters the capacity for glycerol production during iron-limited as well as iron sufficient conditions.	Iron	83-87	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	27-31
10567692-5	1999	Deletion of either GPD1 or GPD2 alters the capacity for glycerol production during iron-limited as well as iron sufficient conditions.	Iron	107-111	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	27-31
10567692-8	1999	In agreement with the pattern of expression of GPD2, this gene product was estimated to account for the bulk of the glycerol production (about 60%) during iron-limited conditions.	Iron	155-159	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	47-51
32452919-7	2020	Novel clinical and preclinical studies highlight the effects of phosphate restriction and iron repletion on FGF23 regulation.	Iron	90-94	fibroblast growth factor 23	Homo sapiens	108-113
10559391-0	1999	Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.	Iron	84-88	activating transcription factor 1	Rattus norvegicus	173-178
32154933-2	2020	Iron status is inversely correlated to the level of circulating FGF-23, and improvement in iron bioavailability within patients correlates with a decrease in FGF-23.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	64-70
32154933-2	2020	Iron status is inversely correlated to the level of circulating FGF-23, and improvement in iron bioavailability within patients correlates with a decrease in FGF-23.	Iron	91-95	fibroblast growth factor 23	Homo sapiens	158-164
32154933-6	2020	We report here that elevations in circulating intact-FGF-23 coincide with the earliest indicators of renal dysfunction (P14), and precede changes in serum phosphate or iron homeostasis.	Iron	168-172	fibroblast growth factor 23	Mus musculus	53-59
32409084-4	2020	Oxidative stress was observed (increased HO-1 expression) in aortic rings after direct exposure to Fe, but not in the presence of catalase or after indirect exposure.	Iron	99-101	heme oxygenase 1	Rattus norvegicus	41-45
10559391-0	1999	Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.	Iron	84-88	cAMP responsive element binding protein 1	Rattus norvegicus	179-183
10559391-0	1999	Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.	Iron	84-88	erythropoietin	Rattus norvegicus	252-266
10559391-6	1999	The protective effects of iron chelators are correlated with their ability to enhance DNA binding of HIF-1 and activating transcription factor 1(ATF-1)/cAMP response element-binding protein (CREB) to the hypoxia response element in cortical cultures and the H19-7 hippocampal neuronal cell line.	Iron	26-30	activating transcription factor 1	Rattus norvegicus	111-144
32541839-0	2020	Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways.	Iron	0-4	DNA damage inducible transcript 4	Homo sapiens	74-79
10559391-6	1999	The protective effects of iron chelators are correlated with their ability to enhance DNA binding of HIF-1 and activating transcription factor 1(ATF-1)/cAMP response element-binding protein (CREB) to the hypoxia response element in cortical cultures and the H19-7 hippocampal neuronal cell line.	Iron	26-30	activating transcription factor 1	Rattus norvegicus	145-150
32541839-8	2020	Instead, activation of AMPK pathway mainly and activation of both HIF-1/REDD1 and Bnip3 pathways partially contribute to iron chelation-induced mTORC1 inhibition.	Iron	121-125	DNA damage inducible transcript 4	Homo sapiens	72-77
10559391-6	1999	The protective effects of iron chelators are correlated with their ability to enhance DNA binding of HIF-1 and activating transcription factor 1(ATF-1)/cAMP response element-binding protein (CREB) to the hypoxia response element in cortical cultures and the H19-7 hippocampal neuronal cell line.	Iron	26-30	cAMP responsive element binding protein 1	Rattus norvegicus	191-195
10559391-7	1999	We show that mRNA, protein, and/or activity levels for genes whose expression is known to be regulated by HIF-1, including glycolytic enzymes, p21(waf1/cip1), and erythropoietin, are increased in cortical neuronal cultures in response to iron chelator treatment.	Iron	238-242	erythropoietin	Rattus norvegicus	163-177
32610126-0	2020	Counter Regulation of Spic by NF-kappaB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.	Iron	85-89	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	22-26
10598021-1	1999	Lactoferrin (LFR) plays an important role in the anti-microbial defense through iron binding, lipopolysaccharide binding and immunomodulation.	Iron	80-84	lactotransferrin	Bos taurus	0-11
32610126-0	2020	Counter Regulation of Spic by NF-kappaB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.	Iron	85-89	signal transducer and activator of transcription 1	Mus musculus	44-48
32610126-3	2020	Functionally, Spic downregulates pro-inflammatory cytokines and promotes iron efflux by regulating ferroportin expression in activated macrophages.	Iron	73-77	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	14-18
32610126-7	2020	Taken together, our findings uncover a pathway wherein counter-regulation of Spic by NF-kappaB and STATs attune inflammatory responses and iron metabolism in macrophages.	Iron	139-143	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	77-81
10598021-1	1999	Lactoferrin (LFR) plays an important role in the anti-microbial defense through iron binding, lipopolysaccharide binding and immunomodulation.	Iron	80-84	lactotransferrin	Bos taurus	13-16
10575556-7	1999	Although the dogma is that the myoglobin is the source of iron, recent studies suggest that cytochrome P450 may be an important source of iron in this model.	Iron	58-62	myoglobin	Homo sapiens	31-40
32670009-8	2020	Interestingly, ALA attenuated 6-OHDA-induced iron accumulation both in vivo and in vitro by antagonizing the 6-OHDA-induced upregulation of iron regulatory protein 2 and divalent metal transporter 1.	Iron	45-49	iron responsive element binding protein 2	Rattus norvegicus	140-165
32670009-8	2020	Interestingly, ALA attenuated 6-OHDA-induced iron accumulation both in vivo and in vitro by antagonizing the 6-OHDA-induced upregulation of iron regulatory protein 2 and divalent metal transporter 1.	Iron	45-49	RoBo-1	Rattus norvegicus	170-198
10560938-0	1999	Role of ceruloplasmin and ascorbate in cellular iron release.	Iron	48-52	ceruloplasmin	Homo sapiens	8-21
10506125-6	1999	Hemin/hydrogen peroxide similarly induced aggregation of alpha-synuclein, and both cytochrome c/hydrogen peroxide- and hemin/hydrogen peroxide-induced aggregation of alpha-synuclein was partially inhibited by treatment with iron chelator deferoxisamine.	Iron	224-228	synuclein alpha	Homo sapiens	57-72
33209248-12	2020	A strong spin-cooperation between the two iron centres also reduces the barrier for second hydrogen atom abstraction, thus making the desaturation pathway competitive.	Iron	42-46	spindlin 1	Homo sapiens	9-13
10506125-6	1999	Hemin/hydrogen peroxide similarly induced aggregation of alpha-synuclein, and both cytochrome c/hydrogen peroxide- and hemin/hydrogen peroxide-induced aggregation of alpha-synuclein was partially inhibited by treatment with iron chelator deferoxisamine.	Iron	224-228	synuclein alpha	Homo sapiens	166-181
32503694-0	2020	Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.	Iron	85-89	monoamine oxidase B	Rattus norvegicus	112-117
10506125-7	1999	This indicates that iron-catalyzed oxidative reaction mediated by cytochrome c/hydrogen peroxide might be critically involved in promoting alpha-synuclein aggregation.	Iron	20-24	synuclein alpha	Homo sapiens	139-154
32503694-7	2020	In brief, a series of hybrids with potential anti-AD effect were successfully obtained, indicating that the design of iron chelators with MAO-B inhibitory and antioxidant activities is an attractive strategy against AD progression.	Iron	118-122	monoamine oxidase B	Rattus norvegicus	138-143
10595578-8	1999	This involves the export of sulfur and possibly iron from mitochondria to the cytosol, a reaction performed by the ABC transporter Atm1p of the mitochondrial inner membrane.	Iron	48-52	ATP binding cassette subfamily B member 7	Homo sapiens	131-136
32484666-0	2020	Correction to Spectroscopic and Computational Studies of Spin States of Iron(IV) Nitrido and Imido Complexes.	Iron	72-76	spindlin 1	Homo sapiens	57-61
10529477-1	1999	The presence of iron in brain tissue in increased concentrations in Parkinson"s disease cases, where it might be responsible for oxidative stress, and the parallel observation that the iron transporter lactoferrin (Lf) was present in increased amounts in surviving neurons, led us to study the synthesis of Lf in a mouse model of Parkinson"s disease.	Iron	16-20	lactotransferrin	Mus musculus	202-213
32369169-6	2020	We discovered that Mom is an iron-binding protein, with loss of Fe2+/3+-binding associated with loss of DNA modification activity.	Iron	29-33	protein mom	Escherichia phage Mu	19-22
10520410-6	1999	Recent data give informations about new proteins involved in iron metabolism: HFE whose gene is mutated in genetic hemochromatosis, ceruloplasmin which permits cellular iron egress and frataxin which is implicated in the exit of iron from mitochondria.	Iron	169-173	ceruloplasmin	Homo sapiens	132-145
10451363-11	1999	It was determined that levels of non-heme and heme (hemoglobin) iron were dramatically decreased in K/VP.5-iNOS cells compared to K/VP.5 cells, thus explaining the decreased intensities of EPR signals of nitrosylated species.	Iron	64-68	inositol-3-phosphate synthase 1	Homo sapiens	107-111
32566816-4	2020	Among them, rare-earth (RE) sulfates RE2(SO4)3 xH2O (RE = Sc, Yb, Y, Dy) show narrower thermal hystereses (less than 50  C), indicating that they have faster reaction rates than the other sulfates M2(SO4)3 xH2O (M = Al, Ga, Fe, In).	Iron	224-226	G protein-coupled receptor 161	Homo sapiens	37-46
32374492-3	2020	This pro-NTA, also called PBAM, is composed of an MIL-100 (Fe)-coated Prussian blue (PB) analogue (K2 Mn[Fe(CN)6 ]) with negligible absorption in the near-infrared region and spatial confinement of Mn2+ ions.	Iron	59-61	solute carrier family 10 member 2	Homo sapiens	26-30
10451363-13	1999	These t-BuOOH-induced radical species were greatly reduced in K/VP.5-iNOS cells compared to K/VP.5 cells, consistent with a reduction in heme iron levels in the iNOS-expressing cells.	Iron	142-146	inositol-3-phosphate synthase 1	Homo sapiens	161-165
10449130-4	1999	These data suggest that ceruloplasmin plays an important role in the protection of neurons against oxidative stress associated with iron metabolism.	Iron	132-136	ceruloplasmin	Homo sapiens	24-37
32113105-5	2020	Further, the results indicated that dietary Fe exposure induced transient changes in the mRNA expression levels of various metal transporters, including the iron transporter dmt1, and the zinc transporters zip8 and zip14.	Iron	44-46	solute carrier family 39 member 8	Danio rerio	206-210
32113105-5	2020	Further, the results indicated that dietary Fe exposure induced transient changes in the mRNA expression levels of various metal transporters, including the iron transporter dmt1, and the zinc transporters zip8 and zip14.	Iron	44-46	solute carrier family 39 member 14	Danio rerio	215-220
18967683-8	1999	The technique was ascertained by comparing the analytical value of total-Fe with the certified value of Fe in the reference standard seawater CASS-3.	Iron	104-106	embryonal Fyn-associated substrate	Homo sapiens	142-148
32209423-7	2020	There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice.	Iron	25-29	ferritin light polypeptide 1	Mus musculus	83-86
32209423-7	2020	There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice.	Iron	25-29	ferritin heavy polypeptide 1	Mus musculus	91-94
10403805-4	1999	Hypoxia, transition metals, iron chelators, and several antioxidants stabilize the HIF-alpha proteins, allowing the formation of the transcriptionally active HIF complex.	Iron	28-32	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	83-86
32307390-8	2020	This case indicates the left dominant parkinsonism was caused by right dominant iron deposition to substantia nigra and globus pallidus in view of MRI findings and DAT SPECT.	Iron	80-84	solute carrier family 6 member 3	Homo sapiens	164-167
10429185-0	1999	The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake.	Iron	28-32	solute carrier family 11 member 2	Homo sapiens	72-78
32442996-9	2020	It is thought that the oxygen vacancies bring about unequal number of Fe2+and Fe3+ions and thereby strengthen the magnetic frustration among the iron ions coupled with antiferromagnetic interactions, leading to the spin glass behavior.	Iron	145-149	spindlin 1	Homo sapiens	215-219
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	157-159	solute carrier family 11 member 2	Homo sapiens	59-109
32501088-4	2020	We derive general formulae for single magnon excitation rates from dark matter scattering, and demonstrate as a proof of principle the projected reach of a yttrium iron garnet target for several dark matter models with spin-dependent interactions.	Iron	164-168	spindlin 1	Homo sapiens	219-223
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	157-159	solute carrier family 11 member 2	Homo sapiens	111-117
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	157-159	solute carrier family 11 member 2	Homo sapiens	139-145
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	198-200	solute carrier family 11 member 2	Homo sapiens	59-109
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	198-200	solute carrier family 11 member 2	Homo sapiens	111-117
32272082-0	2020	Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages.	Iron	53-57	interleukin 33	Mus musculus	0-14
10429185-1	1999	Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes.	Iron	198-200	solute carrier family 11 member 2	Homo sapiens	139-145
32272082-5	2020	IL-33- and IL1RL1-deficient mice showed defective iron recycling and increased splenic iron deposition.	Iron	50-54	interleukin 33	Mus musculus	0-5
10429185-2	1999	Interestingly, there are two splice variants of Nramp2, one with a putative iron-responsive element (IRE) in its 3" untranslated region (UTR) and another without.	Iron	76-80	solute carrier family 11 member 2	Homo sapiens	48-54
32272082-5	2020	IL-33- and IL1RL1-deficient mice showed defective iron recycling and increased splenic iron deposition.	Iron	50-54	interleukin 1 receptor-like 1	Mus musculus	11-17
32272082-5	2020	IL-33- and IL1RL1-deficient mice showed defective iron recycling and increased splenic iron deposition.	Iron	87-91	interleukin 33	Mus musculus	0-5
32272082-5	2020	IL-33- and IL1RL1-deficient mice showed defective iron recycling and increased splenic iron deposition.	Iron	87-91	interleukin 1 receptor-like 1	Mus musculus	11-17
32272082-7	2020	Thus, IL-33 instructs the development of RPMs as a response to physiological erythrocyte damage with important implications to iron recycling and iron homeostasis.	Iron	127-131	interleukin 33	Mus musculus	6-11
32272082-7	2020	Thus, IL-33 instructs the development of RPMs as a response to physiological erythrocyte damage with important implications to iron recycling and iron homeostasis.	Iron	146-150	interleukin 33	Mus musculus	6-11
10429185-3	1999	Due to the importance of Nramp2 in Fe transport, and the presence of an IRE in its 3"-UTR, we have examined the effect of Fe-deprivation, Fe-loading, and nitrogen monoxide on the expression of Nramp2 mRNA.	Iron	122-124	solute carrier family 11 member 2	Homo sapiens	193-199
10429185-3	1999	Due to the importance of Nramp2 in Fe transport, and the presence of an IRE in its 3"-UTR, we have examined the effect of Fe-deprivation, Fe-loading, and nitrogen monoxide on the expression of Nramp2 mRNA.	Iron	122-124	solute carrier family 11 member 2	Homo sapiens	193-199
10429185-10	1999	As Nramp2 can transport Fe from non-Tf-bound Fe, the effect of preincubation with DFO and FAC was also examined on Fe uptake from [59Fe]nitrilotriacetate and [59Fe]citrate.	Iron	24-26	solute carrier family 11 member 2	Homo sapiens	3-9
10429185-10	1999	As Nramp2 can transport Fe from non-Tf-bound Fe, the effect of preincubation with DFO and FAC was also examined on Fe uptake from [59Fe]nitrilotriacetate and [59Fe]citrate.	Iron	45-47	solute carrier family 11 member 2	Homo sapiens	3-9
32393788-3	2020	The fasting-mimicking diet selectivity reverses vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin in KRAS-mutant cancer cells, consequently increasing reactive iron, oxygen species, and cell death; an effect further potentiated by chemotherapy.	Iron	175-179	KRAS proto-oncogene, GTPase	Homo sapiens	116-120
10429185-10	1999	As Nramp2 can transport Fe from non-Tf-bound Fe, the effect of preincubation with DFO and FAC was also examined on Fe uptake from [59Fe]nitrilotriacetate and [59Fe]citrate.	Iron	45-47	solute carrier family 11 member 2	Homo sapiens	3-9
10395484-0	1999	Effects of C-4 stereochemistry and C-4" hydroxylation on the iron clearing efficiency and toxicity of desferrithiocin analogues.	Iron	61-65	complement C4A (Rodgers blood group)	Homo sapiens	11-14
32236868-4	2020	However, FGF23 can be altered for many other reasons, such as inflammatory processes, iron, hypoxia, heart failure or erythropoietin, that negatively affect mortality.	Iron	86-90	fibroblast growth factor 23	Homo sapiens	9-14
10395484-0	1999	Effects of C-4 stereochemistry and C-4" hydroxylation on the iron clearing efficiency and toxicity of desferrithiocin analogues.	Iron	61-65	complement C4A (Rodgers blood group)	Homo sapiens	35-38
10395484-2	1999	The effects of stereochemistry at C-4 on the ligands" iron clearing efficiency are reviewed and assessed using the enantiomers 4,5-dihydro-2-(2, 4-dihydroxyphenyl)thiazole-4(R)-carboxylic acid and 4,5-dihydro-2-(2, 4-dihydroxyphenyl)thiazole-4(S)-carboxylic acid.	Iron	54-58	complement C4A (Rodgers blood group)	Homo sapiens	34-37
31726018-10	2020	Interleukin-6 and monocyte chemotactic protein-1 levels in the BAL fluid increased significantly from baseline in iron-deficient mice, but not in normal diet mice.	Iron	114-118	chemokine (C-C motif) ligand 2	Mus musculus	18-48
10395484-4	1999	The stereochemistry at C-4 is shown to have a substantial effect on the iron clearing efficiency of desferrithiocin analogues, as does C-4"-hydroxylation on the toxicity profile.	Iron	72-76	complement C4A (Rodgers blood group)	Homo sapiens	23-26
10417735-10	1999	The Nramp2 protein was subsequently shown to be the major transferrin-independent iron uptake system of the intestine.	Iron	82-86	solute carrier family 11 member 2	Homo sapiens	4-10
32092383-0	2020	Expanding the phenotype of mitochondrial disease: novel pathogenic variant in ISCA1 leading to instability of the iron-sulfur cluster in the protein.	Iron	114-118	iron-sulfur cluster assembly 1	Homo sapiens	78-83
32092383-4	2020	While ISCA1 is involved in mitochondrial machinery of iron-sulfur cluster biogenesis, these dysfunctions are secondary to impaired maturation of mitochondrial proteins containing the [4Fe-4S] clusters.	Iron	54-58	iron-sulfur cluster assembly 1	Homo sapiens	6-11
10361139-0	1999	Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	45-51
32492011-1	2020	The iron-containing protein neuroglobin (Ngb) involved in the transport of oxygen is generally considered the precursor of all animal globins.	Iron	4-8	neuroglobin	Homo sapiens	28-39
32492011-1	2020	The iron-containing protein neuroglobin (Ngb) involved in the transport of oxygen is generally considered the precursor of all animal globins.	Iron	4-8	neuroglobin	Homo sapiens	41-44
10361139-1	1999	Genetic studies in animal models of microcytic anemia and biochemical studies of transport have implicated the Nramp2 gene in iron transport.	Iron	126-130	solute carrier family 11 member 2	Homo sapiens	111-117
10361139-2	1999	Nramp2 generates two alternatively spliced mRNAs that differ at their 3" untranslated region by the presence or absence of an iron-response element (IRE) and that encode two proteins with distinct carboxy termini.	Iron	126-130	solute carrier family 11 member 2	Homo sapiens	0-6
10361139-6	1999	Dietary iron starvation results in a dramatic upregulation of the Nramp2 isoform I in the proximal portion of the duodenum only, whereas expression in the rest of the small intestine and in kidney remains largely unchanged in response to the lack of dietary iron.	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	66-72
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	9-13	RoBo-1	Rattus norvegicus	100-127
10361139-7	1999	In proximal duodenum, immunostaining studies of tissue sections show that Nramp2 protein expression is abundant under iron deplete condition and limited to the villi and is absent in the crypts.	Iron	118-122	solute carrier family 11 member 2	Homo sapiens	74-80
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	9-13	RoBo-1	Rattus norvegicus	129-133
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	172-176	RoBo-1	Rattus norvegicus	100-127
10361139-10	1999	These results strongly suggest that Nramp2 is indeed responsible for transferrin-independent iron uptake in the duodenum.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	36-42
31518742-7	2020	RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload.	Iron	172-176	RoBo-1	Rattus norvegicus	129-133
32239172-1	2020	Hereditary hemochromatosis (HH) is mostly caused by mutations in the iron-regulatory gene HFE.	Iron	69-73	homeostatic iron regulator	Mus musculus	90-93
10554821-7	1999	Enterocytes of hypotransferrinaemic mice had normal non-haem iron levels and transferrin binding; however, enterocytes from CD-1 mice fed a low iron diet had increased transferrin binding and a decreased non-haem iron content.	Iron	144-148	CD1 antigen complex	Mus musculus	124-128
32239172-13	2020	We conclude that iron/heme overload in HH increases xanthine oxidase activity and also promotes p53 degradation resulting in decreased ABCG2 expression.	Iron	17-21	xanthine dehydrogenase	Mus musculus	52-68
31914428-0	2020	Spin crossover in mononuclear Fe(II) complexes based on a tetradentate ligand.	Iron	30-36	spindlin 1	Homo sapiens	0-4
10554821-7	1999	Enterocytes of hypotransferrinaemic mice had normal non-haem iron levels and transferrin binding; however, enterocytes from CD-1 mice fed a low iron diet had increased transferrin binding and a decreased non-haem iron content.	Iron	144-148	CD1 antigen complex	Mus musculus	124-128
10229861-5	1999	Binding of NF-IL6 to its consensus motif within the iNOS promoter was inducible by IFN-gamma and/or LPS, was reduced by iron, and was enhanced by the iron chelator desferrioxamine.	Iron	120-124	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	11-17
10229861-5	1999	Binding of NF-IL6 to its consensus motif within the iNOS promoter was inducible by IFN-gamma and/or LPS, was reduced by iron, and was enhanced by the iron chelator desferrioxamine.	Iron	150-154	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	11-17
32186552-2	2020	Using computational design, we converted metalloporphyrin specificity of cytochrome b562 from iron to fluorogenic zinc.	Iron	94-98	mitochondrially encoded cytochrome b	Homo sapiens	73-85
10229861-6	1999	Introduction of a double mutation into the NF-IL6 binding site (-153/-142) of an iNOS promoter construct resulted in a reduction of IFN-gamma/LPS inducibility by &gt;90% and also impaired iron mediated regulation of the iNOS promoter.	Iron	188-192	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	43-49
10229861-7	1999	Our results provide evidence that this NF-IL6 binding site is of central importance for maintaining a high transcriptional rate of the iNOS gene after IFN-gamma/LPS stimulation, and that NF-IL6 may cooperate with hypoxia inducible factor-1 in the orchestration of iron-mediated regulation of iNOS.	Iron	264-268	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	39-45
10229861-7	1999	Our results provide evidence that this NF-IL6 binding site is of central importance for maintaining a high transcriptional rate of the iNOS gene after IFN-gamma/LPS stimulation, and that NF-IL6 may cooperate with hypoxia inducible factor-1 in the orchestration of iron-mediated regulation of iNOS.	Iron	264-268	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	187-193
10380640-1	1999	Bovine lactoferrin (LF) and lactoferricin B (LFcin B), an antimicrobial peptide derived from bovine LF, inhibited thiobarbituric acid-reactive substance (TBARS) formation in a iron/ascorbate-induced liposomal phospholipid peroxidation system.	Iron	176-180	lactotransferrin	Bos taurus	7-18
31962167-0	2020	bHLH121 Functions as A Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis.	Iron	124-126	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-7
31962167-6	2020	We found that loss-of-function mutations of bHLH121 cause severe Fe deficiency symptoms, reduced Fe accumulation, and disrupted expression of genes associated with Fe homeostasis.	Iron	65-67	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	44-51
31962167-6	2020	We found that loss-of-function mutations of bHLH121 cause severe Fe deficiency symptoms, reduced Fe accumulation, and disrupted expression of genes associated with Fe homeostasis.	Iron	97-99	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	44-51
31962167-11	2020	Taken together, these results establish a direct link that bHLH121 functions together with bHLH IVc TFs to mediate the activation of FIT and thus plays a pivotal role in maintaining Fe homeostasis in Arabidopsis.	Iron	182-184	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	59-66
10380640-1	1999	Bovine lactoferrin (LF) and lactoferricin B (LFcin B), an antimicrobial peptide derived from bovine LF, inhibited thiobarbituric acid-reactive substance (TBARS) formation in a iron/ascorbate-induced liposomal phospholipid peroxidation system.	Iron	176-180	lactotransferrin	Bos taurus	45-47
10217256-3	1999	We also provide evidence that up-regulation of the stress protein heme oxygenase-1 (HO-1) is both necessary and sufficient for mitochondrial iron trapping in dopamine-challenged astroglia.	Iron	141-145	heme oxygenase 1	Homo sapiens	66-82
32260496-10	2020	The correlations of serum hepcidin and erythroferrone with liver DMT1 and TfR represent significant mechanisms of Fe homeostasis.	Iron	114-116	RoBo-1	Rattus norvegicus	65-69
31697569-10	2020	FENDRR was preferentially localized in the cytoplasm of adult lung fibroblasts and bound IRP1, suggesting its role in iron metabolism.	Iron	118-122	aconitase 1	Mus musculus	89-93
10394943-6	1999	The IRT1 cDNA also complements a zinc uptake-deficient yeast mutant strain (zrt1zrt2), and IRT1-dependent zinc transport in yeast cells is inhibited by cadmium, copper, cobalt and iron(III).	Iron	180-184	IRT1	Saccharomyces cerevisiae S288C	4-8
10394943-6	1999	The IRT1 cDNA also complements a zinc uptake-deficient yeast mutant strain (zrt1zrt2), and IRT1-dependent zinc transport in yeast cells is inhibited by cadmium, copper, cobalt and iron(III).	Iron	180-184	IRT1	Saccharomyces cerevisiae S288C	91-95
32026606-5	2020	As a consequence, both single and hybrid oxides show satisfactory reversible capacities (1206 mAh g -1 for Fe 2 O 3 and 1481 mAh g -1 for Fe 2 O 3 /SnO 2 after 200 cycles at 200 mA g -1 ) and long lifespans.	Iron	138-146	strawberry notch homolog 2	Homo sapiens	148-151
10320628-1	1999	Ceruloplasmin (Cp) is a copper-dependent oxidase with roles that include the regulation of iron metabolism, participation in the acute-phase response to inflammation, and antioxidant systems.	Iron	91-95	ceruloplasmin	Homo sapiens	0-13
32108988-1	2020	The GNPAT variant rs11558492 (p.D519G) was identified as a novel genetic factor that modifies the iron-overload phenotype in homozygous carriers of the HFE p.C282Y variant.	Iron	98-102	homeostatic iron regulator	Mus musculus	152-155
10226046-3	1999	Copper, nonheme and heme iron coordination complexes have been used to mimic reversible dioxygen-binding by the three classes of blood-oxygen carriers - hemocyanin, hemerythrin and hemoglobin/myoglobin - while functional mimics of oxygenases and oxidases with copper and iron have also provided key insights into important dioxygen activation processes.	Iron	25-29	myoglobin	Homo sapiens	192-201
31883180-13	2020	The present results provide in vivo and in vitro evidence that microglial glutamate release in SALS spinal cords is enhanced by intracellular soluble iron accumulation-induced activation of ACO1 and TACE and by increased extracellular TNFalpha-stimulated GLS-C upregulation, and suggest a positive feedback mechanism to maintain increased intracellular soluble iron levels, involving TNFalpha, hepcidin, and FPN.	Iron	150-154	hepcidin antimicrobial peptide	Mus musculus	394-402
32235880-7	2020	GECHO-1 rats also developed hemoglobinuria and hemosiderinuria associated with marked tubular hemosiderin deposition and HO-1 induction, while there was depletion of splenic iron stores.	Iron	174-178	heme oxygenase 1	Rattus norvegicus	3-7
10563980-6	1999	Lactoferrin decreased the prooxidant effect of iron, but not of copper, in emulsions.	Iron	47-51	lactotransferrin	Bos taurus	0-11
31976503-6	2020	Through studies using Cp-/- mice, we find this elevated Cp helps recover serum Fe levels at late stages of infection, consistent with a role for Cp in loading transferrin with Fe.	Iron	176-178	transferrin	Mus musculus	159-170
10090732-5	1999	When the T state interface is weakened by Asp --&gt; Asn substitution at a quaternary H-bond (HbK), the Fe-His bond is relaxed and becomes responsive to allosteric effectors.	Iron	104-106	hemoglobin subunit mu	Homo sapiens	94-97
31973819-5	2020	In addition, LY294002 also inhibited the basal expression of HEPH and FPN1 resulting in blockade of iron egress from cells.	Iron	100-104	hephaestin	Homo sapiens	61-65
31973819-6	2020	In addition, siRNA-silencing of HEPH led to inhibition of both zinc-induced and basal iron transport.	Iron	86-90	hephaestin	Homo sapiens	32-36
10208537-4	1999	Immunoblot analysis showed that human NACP/alpha-synuclein (but not beta-synuclein) aggregated in the presence of ferric ion and was inhibited by the iron chelator deferoxamine.	Iron	114-124	synuclein alpha	Homo sapiens	38-42
32219031-2	2020	Systemic iron homeostasis is regulated by iron-regulatory hormone, hepcidin, which inhibits intestinal iron absorption and iron recycling by reticuloendothelial system.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	67-75
32219031-2	2020	Systemic iron homeostasis is regulated by iron-regulatory hormone, hepcidin, which inhibits intestinal iron absorption and iron recycling by reticuloendothelial system.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	67-75
32219031-2	2020	Systemic iron homeostasis is regulated by iron-regulatory hormone, hepcidin, which inhibits intestinal iron absorption and iron recycling by reticuloendothelial system.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	67-75
10208537-4	1999	Immunoblot analysis showed that human NACP/alpha-synuclein (but not beta-synuclein) aggregated in the presence of ferric ion and was inhibited by the iron chelator deferoxamine.	Iron	114-124	synuclein alpha	Homo sapiens	43-58
10208537-4	1999	Immunoblot analysis showed that human NACP/alpha-synuclein (but not beta-synuclein) aggregated in the presence of ferric ion and was inhibited by the iron chelator deferoxamine.	Iron	150-154	synuclein alpha	Homo sapiens	38-42
32045257-7	2020	Our results not only suggest that the spin-excitation-like bosonic mode within a sign-reversing pairing plays an essential role in monolayer FeTe0.5Se0.5/SrTiO3(001), but also offer the crucial information for investigating the high-temperature superconductivity in interfacial iron selenides.	Iron	141-143	spindlin 1	Homo sapiens	38-42
10208537-4	1999	Immunoblot analysis showed that human NACP/alpha-synuclein (but not beta-synuclein) aggregated in the presence of ferric ion and was inhibited by the iron chelator deferoxamine.	Iron	150-154	synuclein alpha	Homo sapiens	43-58
10066755-1	1999	Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation; it accumulates in the brain during neurodegenerative disorders.	Iron	23-27	lactotransferrin	Bos taurus	0-11
31846105-12	2020	Using both approaches we provide here a systematic analysis of three prototypical transition metal-oxo spin-forbidden processes, involving Cr, Fe and Mn, to investigate their implications on reactivity.	Iron	143-145	spindlin 1	Homo sapiens	103-107
32182331-0	2020	TGFbeta2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology.	Iron	74-78	transforming growth factor beta 2	Homo sapiens	0-8
10066755-1	1999	Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation; it accumulates in the brain during neurodegenerative disorders.	Iron	23-27	lactotransferrin	Bos taurus	13-15
10066755-8	1999	We further report that iron may cross the bovine brain capillary endothelial cells as a complex with Lf.	Iron	23-27	lactotransferrin	Bos taurus	101-103
9931300-1	1999	The polypeptide chain that assembles into the unusual dodecameric shell of Listeria innocua apoferritin lacks the ferroxidase centre characteristic of H-type mammalian chains, but is able to catalyse both Fe(II) oxidation and nucleation of the iron core.	Iron	244-248	ferritin heavy chain 1	Homo sapiens	92-103
32100642-6	2021	However, complete conversion of TOC could not be obtained due to the iron particle deactivation.	Iron	69-73	rhomboid 5 homolog 2	Homo sapiens	32-35
9931300-7	1999	The marked inhibitory effect of Tb(III) on the kinetics of iron incorporation confirms that carboxylates provide the iron ligands in L. innocua apoferritin.	Iron	59-63	ferritin heavy chain 1	Homo sapiens	144-155
32100642-7	2021	XPS, TPO and TEM studies showed the continuous accumulation of carbonaceous materials onto the surface of iron particles.	Iron	106-110	thyroid peroxidase	Homo sapiens	5-8
9924025-0	1999	Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC.	Iron	26-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	77-89	spindlin 1	Homo sapiens	204-208
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	77-89	spindlin 1	Homo sapiens	236-240
9924025-2	1999	Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool.	Iron	137-141	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	6-11
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	77-89	spindlin 1	Homo sapiens	236-240
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	218-225	spindlin 1	Homo sapiens	204-208
9924025-2	1999	Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool.	Iron	182-186	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	6-11
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	218-225	spindlin 1	Homo sapiens	236-240
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	218-225	spindlin 1	Homo sapiens	236-240
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	83-89	spindlin 1	Homo sapiens	204-208
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	83-89	spindlin 1	Homo sapiens	236-240
32022956-2	2020	Herein a spatial-confinement strategy is reported that synthesizes ultrafine alpha-Fe2 O3 benefiting from nanogrids constructed by predeposition of TiO2 nanodots in the MCM-41 channel, and that tunes the spin-state of Fe(III) from high-spin to low-spin induced by the strong guest-host interaction between the ultrafine Fe2 O3 with SiO2 (MCM-41).	Iron	83-89	spindlin 1	Homo sapiens	236-240
32022956-3	2020	The low-spin Fe(III) endorses strong bonding with anionic adsorbates, and significantly facilitates the electrons transfer from Fe2 O3 to SiO2 to form a highly positive charged surface, and thereby shows superior electrostatic multilayer adsorption performance to different kinds of anionic contaminations.	Iron	13-20	spindlin 1	Homo sapiens	8-12
32022956-3	2020	The low-spin Fe(III) endorses strong bonding with anionic adsorbates, and significantly facilitates the electrons transfer from Fe2 O3 to SiO2 to form a highly positive charged surface, and thereby shows superior electrostatic multilayer adsorption performance to different kinds of anionic contaminations.	Iron	128-134	spindlin 1	Homo sapiens	8-12
9924025-4	1999	These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.	Iron	89-93	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	28-33
9924025-4	1999	These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.	Iron	89-93	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	205-210
9788913-1	1998	We have measured the rebinding of carbon monoxide (CO) to some distal mutants of myoglobin (Mb) in the time range from 10(-8) to 10(-1) s by flash photolysis, in which the photodissociated CO rebinds to the heme iron without escaping to the solvent water from the protein matrix.	Iron	212-216	myoglobin	Homo sapiens	81-90
31984437-5	2020	GDF-15 is another gene that plays a role in iron homeostasis and regulation of immune system in different diseases.	Iron	44-48	growth differentiation factor 15	Homo sapiens	0-6
31839625-10	2020	Dex regulates iron metabolism by regulating iron importers and exporters through JNK/Sp1 and Stat4/Sp1 signaling.	Iron	44-48	signal transducer and activator of transcription 4	Homo sapiens	93-98
9788913-1	1998	We have measured the rebinding of carbon monoxide (CO) to some distal mutants of myoglobin (Mb) in the time range from 10(-8) to 10(-1) s by flash photolysis, in which the photodissociated CO rebinds to the heme iron without escaping to the solvent water from the protein matrix.	Iron	212-216	myoglobin	Homo sapiens	92-94
9824471-0	1998	Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium.	Iron	28-32	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	48-54
32160771-7	2020	Mechanistically, we identified Glrx5 (glutaredoxin 5), a critical regulator of mitochondrial iron homeostasis and iron-sulfur cluster synthesis, as a direct miR-152 target.	Iron	93-97	microRNA 152	Mus musculus	157-164
32160771-7	2020	Mechanistically, we identified Glrx5 (glutaredoxin 5), a critical regulator of mitochondrial iron homeostasis and iron-sulfur cluster synthesis, as a direct miR-152 target.	Iron	114-118	microRNA 152	Mus musculus	157-164
9824471-8	1998	These results indicate that an excess of iron hampers Nramp1-encoded function, strongly suggesting a direct involvement of the Nramp1-encoded protein in the transport of this cation.	Iron	41-45	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	54-60
9824471-8	1998	These results indicate that an excess of iron hampers Nramp1-encoded function, strongly suggesting a direct involvement of the Nramp1-encoded protein in the transport of this cation.	Iron	41-45	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	127-133
31904393-0	2020	Iron overload induced by IRP2 gene knockout aggravates symptoms of Parkinson"s disease.	Iron	0-4	iron responsive element binding protein 2	Mus musculus	25-29
9756632-6	1998	Inductively coupled plasma (ICP) spectrometry demonstrated that MBP-DnaJ contains Fe ions as well as Zn ions.	Iron	82-84	DnaJ	Escherichia coli	68-72
31904393-3	2020	Iron regulatory protein 2 (IRP2) plays a critical role in keeping iron homeostasis, and our previous data showed that the deletion of the IRP2 gene caused iron deposits in organs of mice.	Iron	66-70	iron responsive element binding protein 2	Mus musculus	0-25
31904393-3	2020	Iron regulatory protein 2 (IRP2) plays a critical role in keeping iron homeostasis, and our previous data showed that the deletion of the IRP2 gene caused iron deposits in organs of mice.	Iron	66-70	iron responsive element binding protein 2	Mus musculus	27-31
31904393-3	2020	Iron regulatory protein 2 (IRP2) plays a critical role in keeping iron homeostasis, and our previous data showed that the deletion of the IRP2 gene caused iron deposits in organs of mice.	Iron	66-70	iron responsive element binding protein 2	Mus musculus	138-142
31904393-3	2020	Iron regulatory protein 2 (IRP2) plays a critical role in keeping iron homeostasis, and our previous data showed that the deletion of the IRP2 gene caused iron deposits in organs of mice.	Iron	155-159	iron responsive element binding protein 2	Mus musculus	0-25
31904393-3	2020	Iron regulatory protein 2 (IRP2) plays a critical role in keeping iron homeostasis, and our previous data showed that the deletion of the IRP2 gene caused iron deposits in organs of mice.	Iron	155-159	iron responsive element binding protein 2	Mus musculus	27-31
31904393-3	2020	Iron regulatory protein 2 (IRP2) plays a critical role in keeping iron homeostasis, and our previous data showed that the deletion of the IRP2 gene caused iron deposits in organs of mice.	Iron	155-159	iron responsive element binding protein 2	Mus musculus	138-142
31904393-4	2020	Therefore, we further investigated the role of iron overload induced by IRP2 gene deletion in the development of the MPTP-induced PD mouse model in vivo, and the underlying regulatory mechanisms in primary cultures of astrocytes in vitro.	Iron	47-51	iron responsive element binding protein 2	Mus musculus	72-76
31904393-6	2020	In addition, the expression of L-ferritin and iron contents increased significantly in the substantia nigra (SN) of IRP2-/- mice.	Iron	46-50	iron responsive element binding protein 2	Mus musculus	116-120
31904393-9	2020	Our results demonstrated that IRP2 gene deletion induced iron accumulation in the SN, which exacerbated the neuronal apoptosis and Parkinsonism symptoms.	Iron	57-61	iron responsive element binding protein 2	Mus musculus	30-34
31904393-10	2020	At the same time, IRP2 gene deletion increased the iron contents in astrocytes around neurons, which further decreased their protection for neurons and increased the cell apoptosis, ultimately forming a vicious cycle that leads to the onset and progression of PD.	Iron	51-55	iron responsive element binding protein 2	Mus musculus	18-22
10193374-3	1998	HO-1 catabolises heme to bilirubin, free iron and carbon monoxide (CO).	Iron	41-45	heme oxygenase 1	Homo sapiens	0-4
31642128-0	2020	Expression of a dominant-negative AtNEET-H89C protein disrupts iron-sulfur metabolism and iron homeostasis in Arabidopsis.	Iron	63-67	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	34-40
31642128-3	2020	A recently discovered group of 2Fe-2S proteins, termed NEET proteins, was proposed to coordinate iron-sulfur, iron, and ROS homeostasis in mammalian cells.	Iron	97-101	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	55-59
31642128-4	2020	Here we report that disrupting the function of AtNEET, the sole member of the NEET protein family in Arabidopsis thaliana, triggers a leaf-associated Fe-S- and Fe- deficiency responses, elevated iron content in chloroplasts (1.2-1.5 fold), chlorosis, structural damage to chloroplasts, and a high seedling mortality rate.	Iron	150-152	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	47-53
31642128-4	2020	Here we report that disrupting the function of AtNEET, the sole member of the NEET protein family in Arabidopsis thaliana, triggers a leaf-associated Fe-S- and Fe- deficiency responses, elevated iron content in chloroplasts (1.2-1.5 fold), chlorosis, structural damage to chloroplasts, and a high seedling mortality rate.	Iron	150-152	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	49-53
31642128-4	2020	Here we report that disrupting the function of AtNEET, the sole member of the NEET protein family in Arabidopsis thaliana, triggers a leaf-associated Fe-S- and Fe- deficiency responses, elevated iron content in chloroplasts (1.2-1.5 fold), chlorosis, structural damage to chloroplasts, and a high seedling mortality rate.	Iron	195-199	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	47-53
31642128-4	2020	Here we report that disrupting the function of AtNEET, the sole member of the NEET protein family in Arabidopsis thaliana, triggers a leaf-associated Fe-S- and Fe- deficiency responses, elevated iron content in chloroplasts (1.2-1.5 fold), chlorosis, structural damage to chloroplasts, and a high seedling mortality rate.	Iron	195-199	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	49-53
31642128-5	2020	Our findings suggest that disrupting AtNEET function disrupts the transfer of 2Fe-2S clusters from the chloroplastic 2Fe-2S biogenesis pathway to different cytosolic and chloroplastic Fe-S proteins, as well as to the cytosolic Fe-S biogenesis system, and that uncoupling this process triggers a leaf-associated Fe-S- and Fe-deficiency responses that result in iron accumulation in chloroplasts and enhanced ROS accumulation.	Iron	360-364	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	37-43
31642128-6	2020	We further show that AtNEET transfers its 2Fe-2S clusters to DRE2, a key protein of the cytosolic Fe-S biogenesis system, and propose that the availability of 2Fe-2S clusters in the chloroplast and cytosol is linked to iron homeostasis in plants.	Iron	219-223	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	21-27
31937681-10	2020	Our pCREs matched amongst others in vitro binding sites of B3, NAC, bZIP, and TCP TFs, which might be regulators of Fe responses.	Iron	116-118	basic leucine-zipper 8	Arabidopsis thaliana	68-72
31782240-0	2020	Single Crystal X-Ray Diffraction Study of Pressure and Temperature Induced Spin Trapping in a Bistable FeII Hofmann Framework.	Iron	103-115	spindlin 1	Homo sapiens	75-79
31782240-1	2020	High-pressure single crystal X-ray diffraction has been used to trap both the low-spin (LS) and high-spin (HS) states of the iron(II) Hofmann spin crossover framework, [FeII(pdm)(H2O) [Ag(CN)2]2 H2O, under identical experimental conditions, allowing the structural changes arising from the spin-transition to be deconvoluted from previously reported thermal effects.	Iron	125-133	spindlin 1	Homo sapiens	82-86
31782240-1	2020	High-pressure single crystal X-ray diffraction has been used to trap both the low-spin (LS) and high-spin (HS) states of the iron(II) Hofmann spin crossover framework, [FeII(pdm)(H2O) [Ag(CN)2]2 H2O, under identical experimental conditions, allowing the structural changes arising from the spin-transition to be deconvoluted from previously reported thermal effects.	Iron	125-133	spindlin 1	Homo sapiens	101-105
31782240-1	2020	High-pressure single crystal X-ray diffraction has been used to trap both the low-spin (LS) and high-spin (HS) states of the iron(II) Hofmann spin crossover framework, [FeII(pdm)(H2O) [Ag(CN)2]2 H2O, under identical experimental conditions, allowing the structural changes arising from the spin-transition to be deconvoluted from previously reported thermal effects.	Iron	125-133	spindlin 1	Homo sapiens	101-105
31782240-1	2020	High-pressure single crystal X-ray diffraction has been used to trap both the low-spin (LS) and high-spin (HS) states of the iron(II) Hofmann spin crossover framework, [FeII(pdm)(H2O) [Ag(CN)2]2 H2O, under identical experimental conditions, allowing the structural changes arising from the spin-transition to be deconvoluted from previously reported thermal effects.	Iron	125-133	spindlin 1	Homo sapiens	101-105
31799800-4	2020	Here, we reveal stronger degradation of the Fe-N-C structure and four times higher ORR activity loss when performing load cycling AST in O 2 - vs. Ar-saturated pH 1 electrolyte.	Iron	44-50	immunoglobulin kappa variable 1D-39	Homo sapiens	137-140
31799800-6	2020	The load cycling AST in O 2 leads to the loss of a significant fraction of FeN x sites, as shown by energy dispersive X-ray spectroscopy analyses, and to the formation of Fe-oxides.	Iron	75-78	immunoglobulin kappa variable 1D-39	Homo sapiens	24-27
31799800-6	2020	The load cycling AST in O 2 leads to the loss of a significant fraction of FeN x sites, as shown by energy dispersive X-ray spectroscopy analyses, and to the formation of Fe-oxides.	Iron	171-180	immunoglobulin kappa variable 1D-39	Homo sapiens	24-27
31799800-7	2020	The results support that the unexpected carbon corrosion occurring at such low potential in the presence of O 2 is due to reactive oxygen species produced between H 2 O 2 and Fe sites via Fenton reactions.	Iron	175-177	immunoglobulin kappa variable 1D-39	Homo sapiens	108-111
31676164-0	2020	Knockdown of BTS may provide a new strategy to improve cadmium-phytoremediation efficiency by improving iron status in plants.	Iron	104-108	zinc finger protein-like protein	Arabidopsis thaliana	13-16
31676164-2	2020	Owing to the similarity between the ionic hydrated radius of Cd2+ and Fe2+, this study investigated how the Cd tolerance and accumulation of Arabidopsis plants was affected by the knockdown of BTS, a gene that negatively regulates Fe nutrition.	Iron	70-74	zinc finger protein-like protein	Arabidopsis thaliana	193-196
31676164-2	2020	Owing to the similarity between the ionic hydrated radius of Cd2+ and Fe2+, this study investigated how the Cd tolerance and accumulation of Arabidopsis plants was affected by the knockdown of BTS, a gene that negatively regulates Fe nutrition.	Iron	70-72	zinc finger protein-like protein	Arabidopsis thaliana	193-196
31676164-3	2020	After exposure to 40 muM Cd, the BTS-knockdown mutant, bts-1, exhibited greater Fe nutrition and better growth than wild-type plants.	Iron	80-82	zinc finger protein-like protein	Arabidopsis thaliana	33-36
31676164-3	2020	After exposure to 40 muM Cd, the BTS-knockdown mutant, bts-1, exhibited greater Fe nutrition and better growth than wild-type plants.	Iron	80-82	zinc finger protein-like protein	Arabidopsis thaliana	55-58
31676164-6	2020	Further study showed that Fe removal from the growth medium and inhibition of the Fe transporter gene, IRT1, removed the differences observed in the growth and Cd concentration of the bts-1 and wild-type plants, respectively.	Iron	26-28	zinc finger protein-like protein	Arabidopsis thaliana	184-187
31676164-6	2020	Further study showed that Fe removal from the growth medium and inhibition of the Fe transporter gene, IRT1, removed the differences observed in the growth and Cd concentration of the bts-1 and wild-type plants, respectively.	Iron	82-84	iron-regulated transporter 1	Arabidopsis thaliana	103-107
31676164-6	2020	Further study showed that Fe removal from the growth medium and inhibition of the Fe transporter gene, IRT1, removed the differences observed in the growth and Cd concentration of the bts-1 and wild-type plants, respectively.	Iron	82-84	zinc finger protein-like protein	Arabidopsis thaliana	184-187
31967828-6	2020	Instead, the oxidation of [Fe(Gly)2] by m-CPBA is much favorable, which leads to the generation of a high-valent iron(IV)-oxo product.	Iron	113-117	general transcription factor IIE subunit 1	Homo sapiens	26-35
31761321-13	2020	CONCLUSION: local hepcidin can regulate iron metabolism in the kidney by adjusting the expression of FPN1.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	18-26
31743560-4	2020	The catalyst exhibits superior performance for OER with overpotential 270 mV @10 mA/cm 2 and 376 mV @100 mA/cm 2 in alkaline, which is much better than IrO 2 /C and RuO 2 /C and is the best iron-based OER catalyst free of active metals like Ni, Co or precious metals.	Iron	190-194	immunoglobulin kappa variable 1D-39	Homo sapiens	159-170
31801669-6	2020	However, the concentration of iron and total cholesterol (TC) were reduced due to the boosting of ferroportin (Fpn) and ATP binding cassette transporter, subfamily A, member 1 (ABCA1) which are efflux transporters of iron and cholesterol individually.	Iron	30-34	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	177-182
31801669-6	2020	However, the concentration of iron and total cholesterol (TC) were reduced due to the boosting of ferroportin (Fpn) and ATP binding cassette transporter, subfamily A, member 1 (ABCA1) which are efflux transporters of iron and cholesterol individually.	Iron	217-221	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	177-182
31776233-0	2020	The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.	Iron	100-104	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	25-32
31776233-6	2020	bhlh121 loss-of-function mutants displayed severe defects in Fe homeostasis that could be reverted by exogenous Fe supply.	Iron	61-63	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-7
31776233-6	2020	bhlh121 loss-of-function mutants displayed severe defects in Fe homeostasis that could be reverted by exogenous Fe supply.	Iron	112-114	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-7
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-7
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	113-119
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	basic helix-loop-helix protein 100	Arabidopsis thaliana	129-136
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	zinc finger protein-like protein	Arabidopsis thaliana	155-161
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	zinc finger protein-like protein	Arabidopsis thaliana	167-173
31776233-7	2020	bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	227-234
31776233-9	2020	By contrast, Fe availability affects the cellular localization of bHLH121 protein in roots.	Iron	13-15	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	66-73
31994917-0	2020	Association between neutrophil gelatinase-associated lipocalin (NGAL) and iron profile in chronic renal disease.	Iron	74-78	lipocalin 2	Homo sapiens	20-62
31994917-0	2020	Association between neutrophil gelatinase-associated lipocalin (NGAL) and iron profile in chronic renal disease.	Iron	74-78	lipocalin 2	Homo sapiens	64-68
31994917-1	2020	NGAL, also known as lipocalin 2, is a stress protein located on the cell surface that is known for its involvement in iron transport.	Iron	118-122	lipocalin 2	Homo sapiens	0-4
31994917-1	2020	NGAL, also known as lipocalin 2, is a stress protein located on the cell surface that is known for its involvement in iron transport.	Iron	118-122	lipocalin 2	Homo sapiens	20-31
31994917-2	2020	This study is aimed to evaluate the correlation between the iron profile and NGAL concentration in serum among chronic kidney disease patients under dialysis in order to find its diagnostic value with regards to iron deficiency anaemia (IDA).	Iron	60-64	lipocalin 2	Homo sapiens	77-81
31644927-3	2020	Chelating agents are potential neuroprotective and memory enhancing agents as they can trap iron that enters in pathological deposition of beta-amyloid (Abeta) which is a hallmark in AD and memory disorders.	Iron	92-96	amyloid beta precursor protein	Rattus norvegicus	139-159
31980623-6	2020	Inflammation in Muc2-/- mice alters erythrophagocytosis efficiency of splenic macrophages, resulting in an iron-rich milieu that promotes bacterial growth.	Iron	107-111	mucin 2	Mus musculus	16-20
31613081-1	2020	Lcn2 is a host defense protein induced via the innate immune response to sequester iron-loaded bacterial siderophores.	Iron	83-87	lipocalin 2	Homo sapiens	0-4
31613081-3	2020	In this work, we use Hydrogen-Deuterium eXchange (HDX) and Isothermal Titration Calorimetry (ITC) to characterize the binding interaction between Lcn2 and siderophores enterobactin and 2,3-DHBA, in the presence and absence of iron.	Iron	226-230	lipocalin 2	Homo sapiens	146-150
32104504-2	2020	Herein, we reported a biomimetic enzyme cascade delivery nanosystem, tumor-targeted erythrocyte membrane (EM)-cloaked iron-mineralized glucose oxidases (GOx-Fe0@EM-A) for enhancing anticancer efficacy by self-activated in vivo cascade to generate sufficient high toxic  OH at tumor site.	Iron	118-122	hydroxyacid oxidase 1	Homo sapiens	153-156
31820649-5	2020	These results reveal the spin-angular momentum transfer from metallic Pt to a magnetic moment in FePc molecules, which can be used as a spin torque in a molecular system.	Iron	97-101	spindlin 1	Homo sapiens	25-29
31820649-5	2020	These results reveal the spin-angular momentum transfer from metallic Pt to a magnetic moment in FePc molecules, which can be used as a spin torque in a molecular system.	Iron	97-101	spindlin 1	Homo sapiens	136-140
31740582-4	2020	We noted that these genes are involved in the synthesis of glutathione or metabolism of intracellular labile iron and include glutamate-cysteine ligase modifier subunit (Gclm), solute carrier family 7 member 11 (Slc7a11), ferritin heavy chain 1 (Fth1), ferritin light chain 1 (Ftl1), and solute carrier family 40 member 1 (Slc40a1).	Iron	109-113	ferritin heavy polypeptide 1	Mus musculus	222-244
31740582-4	2020	We noted that these genes are involved in the synthesis of glutathione or metabolism of intracellular labile iron and include glutamate-cysteine ligase modifier subunit (Gclm), solute carrier family 7 member 11 (Slc7a11), ferritin heavy chain 1 (Fth1), ferritin light chain 1 (Ftl1), and solute carrier family 40 member 1 (Slc40a1).	Iron	109-113	ferritin heavy polypeptide 1	Mus musculus	246-250
31418854-1	2020	Hepcidin (HAMP) synthesis is suppressed by erythropoiesis to increase iron availability for red blood cell production.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	0-8
31418854-1	2020	Hepcidin (HAMP) synthesis is suppressed by erythropoiesis to increase iron availability for red blood cell production.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	10-14
32547968-8	2020	Conclusion: Fibroblast growth factor 23 (FGF23) is a protein that increases renal phosphate wasting and certain parenteral iron therapies may increase the activity of FGF23.	Iron	123-127	fibroblast growth factor 23	Homo sapiens	41-46
32547968-8	2020	Conclusion: Fibroblast growth factor 23 (FGF23) is a protein that increases renal phosphate wasting and certain parenteral iron therapies may increase the activity of FGF23.	Iron	123-127	fibroblast growth factor 23	Homo sapiens	167-172
32065557-7	2020	Regarding the lipase characterization, maximum relative activity was obtained at pH 7.0 and at 35  C. An inhibitory effect was observed for Ca2+, Mn2+, Zn2+, Fe2+, and Cu2+ ions.	Iron	158-162	probable feruloyl esterase A	Triticum aestivum	14-20
31669099-0	2020	Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway.	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	74-82
31669099-3	2020	We investigated the effect of PPIs on the peptide hepcidin, an important iron regulatory hormone.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	50-58
31669099-11	2020	Taken together, PPIs directly affect iron metabolism by suppressing iron absorption through the inhibition of duodenal ferroportin via hepcidin upregulation.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	135-143
9730818-8	1998	These results show that NO binding to sGC not only leads to the cleavage of the Fe-His bond but also induces a conformational change which opens the heme proximal pocket large enough to accommodate an exogenous imidazole molecule.	Iron	80-82	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	38-41
9785469-1	1998	Lactoferrin is a mammalian iron-binding glycoprotein present in many biological secretions, such as milk, tears, semen and plasma and a major component of the specific granules of polymorphonuclear leucocytes.	Iron	27-31	lactotransferrin	Bos taurus	0-11
9748051-0	1998	Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.	Iron	42-46	synuclein alpha	Homo sapiens	89-104
9748051-3	1998	Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer"s disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.	Iron	44-48	synuclein alpha	Homo sapiens	145-160
9748051-3	1998	Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer"s disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.	Iron	44-48	synuclein alpha	Homo sapiens	243-258
9729418-1	1998	New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism.	Iron	153-157	intelectin 1	Homo sapiens	28-31
9729418-1	1998	New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism.	Iron	153-157	intelectin 1	Homo sapiens	33-58
9729418-1	1998	New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism.	Iron	153-157	melanotransferrin	Homo sapiens	66-83
9729418-1	1998	New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism.	Iron	153-157	ceruloplasmin	Homo sapiens	86-88
9729418-1	1998	New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism.	Iron	153-157	ceruloplasmin	Homo sapiens	90-103
9708577-6	1998	Tissue associated myeloperoxidase (MPO) activity was increased in all iron-overloaded animals.	Iron	70-74	myeloperoxidase	Rattus norvegicus	18-33
9708577-6	1998	Tissue associated myeloperoxidase (MPO) activity was increased in all iron-overloaded animals.	Iron	70-74	myeloperoxidase	Rattus norvegicus	35-38
9679449-5	1998	Using this method, the formal iron (V) state of native myoglobin could be spectroscopically characterized for the first time.	Iron	30-34	myoglobin	Homo sapiens	55-64
9679449-7	1998	On this basis, the same structure is proposed for the formal iron(V) state of native myoglobin.	Iron	61-65	myoglobin	Homo sapiens	85-94
9642100-1	1998	Nramp2 is a gene encoding a transmembrane protein that is important in metal transport, in particular iron.	Iron	102-106	solute carrier family 11 member 2	Homo sapiens	0-6
9642100-3	1998	Nramp2 contains a classical iron responsive element in the 3" untranslated region that confers iron dependent mRNA stabilization.	Iron	28-32	solute carrier family 11 member 2	Homo sapiens	0-6
9642100-3	1998	Nramp2 contains a classical iron responsive element in the 3" untranslated region that confers iron dependent mRNA stabilization.	Iron	95-99	solute carrier family 11 member 2	Homo sapiens	0-6
9642100-4	1998	In this report, we describe a splice variant form of human nramp2 that has the carboxyl terminal 18 amino acids substituted with 25 novel amino acids and has a new 3" untranslated region lacking a classical iron-responsive element.	Iron	207-211	solute carrier family 11 member 2	Homo sapiens	59-65
9855066-1	1998	BACKGROUND/AIMS: The present study was designed to investigate whether the acute phase protein alpha-1-antitrypsin (alpha1-AT), which has an inhibitory effect on transferrin (tf) receptor-mediated iron uptake in K562 and THP1 cells, has a similar effect in PLC/PRF/5 cells.	Iron	197-201	heparan sulfate proteoglycan 2	Homo sapiens	257-260
9652407-0	1998	Transferrins--a mechanism for iron uptake by lactoferrin.	Iron	30-34	lactotransferrin	Bos taurus	45-56
9652407-1	1998	Iron uptake by bovine lactoferrin from nitrilotriacetatoFe(III) [FeN(Ac)3] in the presence of bicarbonate has been investigated at pH 7.1-8.7.	Iron	0-4	lactotransferrin	Bos taurus	22-33
9652407-8	1998	In order to analyse the cooperativity between these iron-binding sites, the three-dimensional position of the chain of amino acid residues separating the N and C lobes of human apo-, holo- and dicopper-lactoferrin have been compared by the recognition of the three-dimensional shape dissimilarity program.	Iron	52-56	lactotransferrin	Bos taurus	202-213
9560297-1	1998	The major subunit [rat hepatic lectin-1 (RHL-1)] of the asialoglycoprotein (ASGP) receptor mediates endocytosis of the iron-binding protein lactoferrin (Lf) by isolated rat hepatocytes, yet iron loading of cultured adult rat hepatocytes increases the binding and endocytosis of Lf while greatly inhibiting the uptake of desialylated ligand.	Iron	119-123	lactotransferrin	Rattus norvegicus	140-151
9560297-1	1998	The major subunit [rat hepatic lectin-1 (RHL-1)] of the asialoglycoprotein (ASGP) receptor mediates endocytosis of the iron-binding protein lactoferrin (Lf) by isolated rat hepatocytes, yet iron loading of cultured adult rat hepatocytes increases the binding and endocytosis of Lf while greatly inhibiting the uptake of desialylated ligand.	Iron	119-123	lactotransferrin	Rattus norvegicus	153-155
9560297-6	1998	ASOR and anti-RHL-1 sera blocked the binding and endocytosis of 125I-Lf on control cells but not on iron-loaded cells, indicating that the iron-induced Lf-binding site on hepatocytes is not RHL-1.	Iron	139-143	lactotransferrin	Rattus norvegicus	69-71
9572292-1	1998	Heme oxygenase isozymes, HO-1 (also known as hsp32) and HO-2, are the source for the formation of the putative messenger molecule carbon monoxide (CO), reactive iron, and the in vitro antioxidant bilirubin.	Iron	161-165	heme oxygenase 2	Mus musculus	56-60
9535897-1	1998	The crystal structure of the bovine Rieske iron-sulfur protein indicates a sulfur atom (S-1) of the iron-sulfur cluster and the sulfur atom (Sgamma) of a cysteine residue that coordinates one of the iron atoms form hydrogen bonds with the hydroxyl groups of Ser-163 and Tyr-165, respectively.	Iron	100-104	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Bos taurus	36-62
9521721-9	1998	These results provide further evidence that NOR is indeed structurally related to heme-copper oxidases and that it contains a heme/non-heme iron spin-coupled pair at the active site.	Iron	140-144	cbb3-type cytochrome c oxidase subunit I	Pseudomonas stutzeri	44-47
9546033-12	1998	In human beings, an analogous function may be served by ceruloplasmin, a multicopper oxidase with a role in iron homeostasis.	Iron	108-112	ceruloplasmin	Homo sapiens	56-69
31734319-10	2020	In summary, our findings demonstrate the clear hepatoprotective effect of G-CK against SVP-induced hepatotoxicity through the antioxidant effect, regulation of peroxisome pathway relying on sEH (P80299) downregulation, as well as regulation of iron homeostasis dependent on hepcidin upregulation.	Iron	244-248	epoxide hydrolase 2	Rattus norvegicus	190-193
9564183-0	1998	Identification of Nramp2 as an iron transport protein: another piece of the intestinal iron absorption puzzle.	Iron	31-35	solute carrier family 11 member 2	Homo sapiens	18-24
31922805-2	2019	We here experimentally observe magnon mediated transport of spin (angular) momentum through a 13.4-nm thin yttrium iron garnet film with full control of the magnetic damping via spin-orbit torque.	Iron	115-119	spindlin 1	Homo sapiens	60-64
9564183-0	1998	Identification of Nramp2 as an iron transport protein: another piece of the intestinal iron absorption puzzle.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	18-24
9781347-1	1998	Lactoferrin is a member of the transferrin family of iron-binding proteins to which several physiological functions have been ascribed.	Iron	53-57	lactotransferrin	Mus musculus	0-11
31802666-7	2019	In contrast, in suspensions containing 20 mM Fe(II) alone or Fe-free clay mineral (Syn-1), we observed a purely Fe(II)-containing precipitate (Fe(OH)2) and also PCE and TCE reduction products.	Iron	45-47	synapsin I	Homo sapiens	83-88
31802666-8	2019	Interestingly, the amount of CE products decreased in the order of Fe-free clay mineral Syn-1 > Fe(OH)2 > low Fe-content clay mineral SWy-2, suggesting that clay mineral Fe controlled the formation of the reactive mineral phase.	Iron	67-69	synapsin I	Homo sapiens	88-93
31847813-7	2019	Our growth assays revealed that the shiF-deleted mutants grew significantly slower than the wild-type strain S88 in iron-depleted medium with a decrease of maximum growth rates of 23 and 28% (p &lt; 0.05).	Iron	116-120	ShiF	Escherichia coli	36-40
9781353-1	1998	Development of secretory activity, the localization of lactoferrin in the secretory pathway, and interactions of lactoferrin with milk iron.	Iron	135-139	lactotransferrin	Mus musculus	113-124
9460811-4	1998	Genetic defects of proteins essential for transport of iron into and out of cells (transferrin and ceruloplasmin) deprive the erythron of the metal and cause its accumulation in other vital organs.	Iron	55-59	ceruloplasmin	Homo sapiens	99-112
31619363-10	2019	Studying aortic rings, we found that iron significantly either prevents or reverts the high-Pi induced collagen deposition and the elastin decrease, preserving elastin structure (0.7 +- 0.1 vs 1.2 +- 0.1; Pi vs Pi + Fe, p &lt; 0.05, elastin mRNA relative expression).	Iron	37-41	elastin	Homo sapiens	131-138
31619363-10	2019	Studying aortic rings, we found that iron significantly either prevents or reverts the high-Pi induced collagen deposition and the elastin decrease, preserving elastin structure (0.7 +- 0.1 vs 1.2 +- 0.1; Pi vs Pi + Fe, p &lt; 0.05, elastin mRNA relative expression).	Iron	37-41	elastin	Homo sapiens	160-167
31619363-10	2019	Studying aortic rings, we found that iron significantly either prevents or reverts the high-Pi induced collagen deposition and the elastin decrease, preserving elastin structure (0.7 +- 0.1 vs 1.2 +- 0.1; Pi vs Pi + Fe, p &lt; 0.05, elastin mRNA relative expression).	Iron	37-41	elastin	Homo sapiens	160-167
31920940-2	2019	In this prospective, explorative study the iron accumulation in deep gray matter nuclei (DGM) in myotonic dystrophy type 1 (DM1) and 2 (DM2) and its clinical and neuro-cognitive relevance using susceptibility and R2* mapping was examined.	Iron	43-47	DM1 protein kinase	Homo sapiens	97-134
31920940-8	2019	Iron accumulation in DGM reflected by R2* or susceptibility was found in the putamen and accumbens of DM1 and in DM2, but was more widespread in DM1 (caudate, pallidum, hippocampus, subthalamic nucleus, thalamus, and substantia nigra).	Iron	0-4	DM1 protein kinase	Homo sapiens	102-105
31920940-8	2019	Iron accumulation in DGM reflected by R2* or susceptibility was found in the putamen and accumbens of DM1 and in DM2, but was more widespread in DM1 (caudate, pallidum, hippocampus, subthalamic nucleus, thalamus, and substantia nigra).	Iron	0-4	DM1 protein kinase	Homo sapiens	145-148
31676601-10	2019	These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs.	Iron	90-94	ferritin heavy polypeptide 1	Mus musculus	304-324
9428699-2	1997	Uptake of transferrin and iron doubled 24 h after exposure to erythropoietin, due to a twofold rise in surface transferrin receptors.	Iron	26-30	erythropoietin	Mus musculus	62-76
9428699-3	1997	In addition, a tenfold increase in iron incorporation into haem was observed after erythropoietin stimulation, as iron taken up from transferrin was directed towards haem biosynthesis and away from storage in ferritin.	Iron	35-39	erythropoietin	Mus musculus	83-97
31748741-3	2019	Haem synthesis is completed in mitochondria, with ferrochelatase adding iron to protoporphyrin IX.	Iron	72-76	ferrochelatase	Mus musculus	50-64
9428699-3	1997	In addition, a tenfold increase in iron incorporation into haem was observed after erythropoietin stimulation, as iron taken up from transferrin was directed towards haem biosynthesis and away from storage in ferritin.	Iron	114-118	erythropoietin	Mus musculus	83-97
9402067-8	1997	These results indicate that gp120 is capable of promoting iron-based oxygen free radical damage to U937 cells.	Iron	58-62	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
31795168-4	2019	As a result of the iron leaching, a synergistic effect of both homogeneous and heterogeneous catalysis was observed in pyrite/PDS, whereas heterogeneous catalytic oxidation dominated pyrite/H2O2.	Iron	19-23	solute carrier family 26 member 4	Homo sapiens	126-129
9398529-1	1997	The three-dimensional structure of diferric bovine lactoferrin (bLf) has been determined by X-ray crystallography in order to investigate the factors that influence iron binding and release by transferrins.	Iron	165-169	lactotransferrin	Bos taurus	51-62
31763072-4	2019	Twenty-six SOD genes were identified from the whole genome of wheat, including 17 Cu/Zn-SODs, six Fe-SODs, and three Mn-SODs.	Iron	98-100	SOD	Triticum aestivum	11-14
31668704-0	2019	The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals.	Iron	46-50	bolA family member 2	Homo sapiens	19-24
31668704-9	2019	Our results indicate that BOLA2 participates in iron homeostasis in vivo, and its expansion has a potential adaptive role in protecting against iron deficiency.	Iron	48-52	bolA family member 2	Homo sapiens	26-31
9418837-9	1997	Molecular analysis of the HLA-H gene is indicated in the assessment of patients with iron overload including those currently being treated by venesection.	Iron	85-89	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	26-31
31693663-6	2019	Using a systems approach that combines GWAS, network-based candidate identification, and reverse genetic screen, we identified new genes that regulate root growth in -P-Fe: VIM1, FH6, and VDAC3.	Iron	169-171	formin homolog 6	Arabidopsis thaliana	179-182
9369199-4	1997	In this report we describe a novel finding that the 104 kDa chaperone protein exhibits affinity for iron containing proteins such as transferrins from several species, human lactoferrin and microbial ferric binding protein (FBP).	Iron	100-104	folate receptor beta	Homo sapiens	224-227
31476294-2	2019	Early studies suggest the protective function of LCN2 in which it acts as a bacteriostatic agent that competes with bacteria for iron-bound siderophores.	Iron	129-133	lipocalin 2	Homo sapiens	49-53
9379177-4	1997	Binding investigations on the natural substrates SCN- and I-, at varying pH and temperature, showed that their interaction with lactoperoxidase involves the protonation of a common site in proximity of the iron (possibly distal histidine).	Iron	206-210	lactoperoxidase	Bos taurus	128-143
31401526-7	2019	Moreover, significantly changed expression of TFRC, FTL and FTH1 hinted that dysfunction of iron uptake and storage is a major inducer of ferroptosis.	Iron	92-96	ferritin light chain	Homo sapiens	52-55
9326939-5	1997	Human PAHX is targetted to peroxisomes, requires the PTS2 receptor for peroxisomal localization, interacts with the PTS2 receptor in the yeast two-hybrid assay and has intrinsic phytanoyl-CoA alpha-hydroxylase activity that requires the dioxygenase cofactor iron and cosubstrate 2-oxoglutarate.	Iron	258-262	phytanoyl-CoA 2-hydroxylase	Homo sapiens	6-10
31532427-7	2019	Here we determine the metal : protein stoichiometry for Isu1 Zn and Fe binding to be 1 : 1 and 2 : 1, respectively.	Iron	68-70	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	56-60
31532427-13	2019	Finally, in our report Zn binding dramatically reduces the Fe-S cluster assembly activity of Isu1 even in the presence of frataxin.	Iron	59-63	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	93-97
9242695-6	1997	These studies therefore suggest that the GPI-anchored form of ceruloplasmin may play a role similar to the secreted form in oxidizing ferrous iron.	Iron	142-146	ceruloplasmin	Homo sapiens	62-75
31532427-14	2019	Given the Fe-binding activity we report for Isu1 and its orthologs here, a possible mechanism involving Fe(ii) transport to the scaffold"s active site during cluster assembly has been considered.	Iron	10-12	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	44-48
31552988-1	2019	Cellular adaptation to excess iron (Fe) is a major determinant to protect tissues from toxicity.	Iron	30-34	general transcription factor IIE subunit 1	Homo sapiens	36-38
9271100-9	1997	Evidence showing modulation of Nramp1 protein levels by iron chelation provides a direct link with Nramp1 function and divalent-cation metabolism.	Iron	56-60	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	31-37
9207117-3	1997	Besides complementing ctr1 growth defect on nonfermentable media, the human gene also rescues iron transport and SOD1 defects in ctr1 yeast.	Iron	94-98	solute carrier family 31 member 1	Homo sapiens	22-26
31076252-7	2019	In this study, we demonstrated that iron deprivation increased the amount of ALAS2 mRNA as well as the ratio of ALAS2 to FECH mRNAs in cultured erythroleukemic K562 cells.	Iron	36-40	ferrochelatase	Homo sapiens	121-125
9169617-1	1997	Isolated rat hepatocytes bind and internalize bovine lactoferrin (Lf) and its bound iron in a Ca2+-dependent manner.	Iron	84-88	lactotransferrin	Bos taurus	53-64
31857947-12	2019	The concentrations of Fe, Co, Ni, Cu, Zn and Br were significantly higher in the KRAS mutation and wild-type groups than in the control group regardless of whether the samples were from tumor or peritumor tissues.	Iron	22-24	KRAS proto-oncogene, GTPase	Homo sapiens	81-85
31659150-5	2019	Furthermore, we show that autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/- and LC3B-/-.	Iron	45-49	beclin 1	Homo sapiens	205-210
9083054-0	1997	A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport.	Iron	76-80	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	40-44
31681872-4	2019	To increase the iron loading and the number of iron-centered catalytically active sites, we selected three iron salts Fe(OAc)2, Fe(OTf)2, and Fe(BF4)2 6H2O, which show greatly enhanced solubility in the liquid carbon precursor (furfurylamine) compared to FeCl3 6H2O.	Iron	16-20	POU class 2 homeobox 2	Homo sapiens	128-136
9083054-2	1997	We now provide evidence that Atx1p helps deliver copper to the copper requiring oxidase Fet3p involved in iron uptake.	Iron	106-110	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	29-34
31681872-4	2019	To increase the iron loading and the number of iron-centered catalytically active sites, we selected three iron salts Fe(OAc)2, Fe(OTf)2, and Fe(BF4)2 6H2O, which show greatly enhanced solubility in the liquid carbon precursor (furfurylamine) compared to FeCl3 6H2O.	Iron	47-51	POU class 2 homeobox 2	Homo sapiens	128-136
31681872-4	2019	To increase the iron loading and the number of iron-centered catalytically active sites, we selected three iron salts Fe(OAc)2, Fe(OTf)2, and Fe(BF4)2 6H2O, which show greatly enhanced solubility in the liquid carbon precursor (furfurylamine) compared to FeCl3 6H2O.	Iron	47-51	POU class 2 homeobox 2	Homo sapiens	128-136
9119894-3	1997	In this study, we determined if iron loading of primary cultures of adult rat hepatocytes altered their ability to bind and internalize Lf.	Iron	32-36	lactotransferrin	Rattus norvegicus	136-138
31681872-5	2019	The increased solubility leads to a significantly higher iron loading in the Fe-OMC prepared with Fe(OTf)2, but the increase in performance as cathode catalysts in fuel cells is only marginal.	Iron	57-61	POU class 2 homeobox 2	Homo sapiens	101-106
31681872-5	2019	The increased solubility leads to a significantly higher iron loading in the Fe-OMC prepared with Fe(OTf)2, but the increase in performance as cathode catalysts in fuel cells is only marginal.	Iron	77-79	POU class 2 homeobox 2	Homo sapiens	101-106
9119894-7	1997	Both 125I-Lf binding at 4 degrees C and endocytosis at 37 degrees C increased up to sixfold between 0.3 10 microg/mL FAC, indicating that iron-induced enhancement of 125I-Lf uptake was due to an increase in the number of Lf receptors present on the cells.	Iron	138-142	lactotransferrin	Rattus norvegicus	10-12
9119894-7	1997	Both 125I-Lf binding at 4 degrees C and endocytosis at 37 degrees C increased up to sixfold between 0.3 10 microg/mL FAC, indicating that iron-induced enhancement of 125I-Lf uptake was due to an increase in the number of Lf receptors present on the cells.	Iron	138-142	lactotransferrin	Rattus norvegicus	171-173
9119894-7	1997	Both 125I-Lf binding at 4 degrees C and endocytosis at 37 degrees C increased up to sixfold between 0.3 10 microg/mL FAC, indicating that iron-induced enhancement of 125I-Lf uptake was due to an increase in the number of Lf receptors present on the cells.	Iron	138-142	lactotransferrin	Rattus norvegicus	171-173
31532179-2	2019	Here we report a facile strategy to immobilize an enzyme, glucose oxidase (GOx), on PCN-222(Fe) induced by electrostatic interaction, in which PCN-222(Fe) serves as both a support and chemocatalyst.	Iron	92-94	hydroxyacid oxidase 1	Homo sapiens	58-73
31532179-2	2019	Here we report a facile strategy to immobilize an enzyme, glucose oxidase (GOx), on PCN-222(Fe) induced by electrostatic interaction, in which PCN-222(Fe) serves as both a support and chemocatalyst.	Iron	92-94	hydroxyacid oxidase 1	Homo sapiens	75-78
9163514-1	1997	The iron complex of beta,delta-diazamesoporphyrin III, a molecular hybrid of porphyrin and phthalocyanine, was incorporated into apomyoglobin to investigate novel biological aspects of myoglobin.	Iron	4-8	myoglobin	Homo sapiens	132-141
31532179-2	2019	Here we report a facile strategy to immobilize an enzyme, glucose oxidase (GOx), on PCN-222(Fe) induced by electrostatic interaction, in which PCN-222(Fe) serves as both a support and chemocatalyst.	Iron	151-153	hydroxyacid oxidase 1	Homo sapiens	58-73
31532179-2	2019	Here we report a facile strategy to immobilize an enzyme, glucose oxidase (GOx), on PCN-222(Fe) induced by electrostatic interaction, in which PCN-222(Fe) serves as both a support and chemocatalyst.	Iron	151-153	hydroxyacid oxidase 1	Homo sapiens	75-78
31532179-7	2019	GOx/PCN-222(Fe) also displays desirable recyclability, since no significant loss of conversion rates was found after 6 repeated reactions.	Iron	12-14	hydroxyacid oxidase 1	Homo sapiens	0-3
9079716-6	1997	SDS-polyacrylamide gel electrophoresis and absorbance measurements of purified transgenic hLF showed this protein was 90% saturated with iron, whereas natural hLF is only 3% saturated.	Iron	137-141	HLF transcription factor, PAR bZIP family member	Homo sapiens	90-93
31487266-2	2019	We previously showed that sGC heme iron reduction (Fe3+   Fe2+) is modulated by cytochrome b5 reductase 3 (CYB5R3).	Iron	35-39	cytochrome b5 reductase 3	Mus musculus	80-105
31487266-2	2019	We previously showed that sGC heme iron reduction (Fe3+   Fe2+) is modulated by cytochrome b5 reductase 3 (CYB5R3).	Iron	35-39	cytochrome b5 reductase 3	Mus musculus	107-113
9079716-7	1997	The pH-mediated release of iron from transgenic hLF was not different from that of iron-saturated natural hLF.	Iron	27-31	HLF transcription factor, PAR bZIP family member	Homo sapiens	48-51
9079716-8	1997	Unsaturated transgenic hLF could be completely resaturated upon addition of iron.	Iron	76-80	HLF transcription factor, PAR bZIP family member	Homo sapiens	23-26
31634395-5	2019	In addition, because the NSR expresses the iron regulatory hormone hepcidin, which could limit iron influx into the NSR, we gave retina-specific hepcidin knockout (RS-HepcKO) mice IP FeDex to test this possibility.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	67-75
9041227-7	1997	Although the dogma is that the myoglobin is the source of iron, the results of recent studies suggest that cytochrome P-450 may be an important source of iron in this model.	Iron	58-62	myoglobin	Homo sapiens	31-40
31190117-1	2019	MAIN CONCLUSION: A MAPK module, of which MPK6 kinase is an important component, is involved in the coordination of the responses to Pi and Fe in the primary root meristem of Arabidopsis thaliana.	Iron	139-141	MAP kinase 6	Arabidopsis thaliana	41-45
31190117-4	2019	MPK6 activity is induced in roots in response to low Pi, and such induction is enhanced by Fe supplementation, suggesting an MPK6 role in coordinating Pi/Fe balance in mediating root growth.	Iron	91-93	MAP kinase 6	Arabidopsis thaliana	0-4
31195489-2	1997	When infection occurred in the presence of 1 mg/ml of bovine lactoferrin, in the form of apolactoferrin or iron- or manganese-saturated forms, the adhesion of bacteria to eukaryotk cells was unaffected, but the number of internalized bacteria was reduced by 42- to 125-fold.	Iron	107-111	lactotransferrin	Bos taurus	61-72
31190117-4	2019	MPK6 activity is induced in roots in response to low Pi, and such induction is enhanced by Fe supplementation, suggesting an MPK6 role in coordinating Pi/Fe balance in mediating root growth.	Iron	91-93	MAP kinase 6	Arabidopsis thaliana	125-129
31190117-4	2019	MPK6 activity is induced in roots in response to low Pi, and such induction is enhanced by Fe supplementation, suggesting an MPK6 role in coordinating Pi/Fe balance in mediating root growth.	Iron	154-156	MAP kinase 6	Arabidopsis thaliana	0-4
31190117-4	2019	MPK6 activity is induced in roots in response to low Pi, and such induction is enhanced by Fe supplementation, suggesting an MPK6 role in coordinating Pi/Fe balance in mediating root growth.	Iron	154-156	MAP kinase 6	Arabidopsis thaliana	125-129
31190117-6	2019	Our results indicate a critical role of the MPK6 kinase in coordinating meristem cell activity to Pi and Fe availability for proper primary root growth.	Iron	105-107	MAP kinase 6	Arabidopsis thaliana	44-48
31429583-6	2019	In this work, LASSCF is applied to predict spin-state energetics in mono- and di-iron systems, and we show that the model offers an accuracy equivalent to that of CASSCF but at a substantially lower computational cost.	Iron	81-85	spindlin 1	Homo sapiens	43-47
9009306-3	1997	We had previously demonstrated that human lactoferrin (HLf) supported full growth of the bacteria in media lacking other iron sources.	Iron	121-125	HLF transcription factor, PAR bZIP family member	Homo sapiens	55-58
31323261-10	2019	Treatment with phenylhydrazine in mice, well-reported iron overload liver injury model, increased ALT and AST levels and altered histological features, which were almost completely inhibited by adenoviral Sesn2 infection.	Iron	54-58	sestrin 2	Mus musculus	205-210
31323261-11	2019	Collectively, our results suggest that ferroptosis-mediated Sesn2 induction is dependent on Nrf2 and plays a protective role against iron overload and ferroptosis-induced liver injury.	Iron	133-137	sestrin 2	Mus musculus	60-65
9009306-4	1997	The ability of H. pylori to use HLf as an iron source had been found to be dependent on cell-to-protein contact.	Iron	42-46	HLF transcription factor, PAR bZIP family member	Homo sapiens	32-35
9009306-5	1997	Since lactoferrin has been found in significant amounts in human stomach resection specimens from patients with superficial or atrophic gastritis, the iron uptake of H. pylori via a specific HLf receptor may play a major role in the virulence of H. pylori infection.	Iron	151-155	HLF transcription factor, PAR bZIP family member	Homo sapiens	191-194
9378100-10	1997	This effect may represent the molecular mechanism underlying the dynamic transition observed for the mean square displacements of the protein atoms and the heme iron of myoglobin.	Iron	161-165	myoglobin	Homo sapiens	169-178
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	transcription factor 7 like 2	Sus scrofa	279-285
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	NFKB inhibitor zeta	Sus scrofa	308-314
31477014-8	2019	A list of candidate genes showing functional and/or structural associations with FE was elaborated based on results from both AWM and gene expression analyses, and included the aforementioned TF genes and other ones that have key roles in metabolism, e.g. ESRRG, RXRG, PPARGC1A, TCF7L2, LHX4, MAML2, NFATC3, NFKBIZ, TCEA1, CDCA7L, LZTFL1 or CBFB.	Iron	81-83	cell division cycle associated 7 like	Sus scrofa	323-329
8981044-5	1997	Interleukin-1 alpha and beta mRNA showed two peaks at 6 h and 72 h. The inhibition of catalase by aminotriazol (ATZ), inhibition of GSHPx by buthionine sulfoximine (BSO), and blocking the Fenton reaction by the iron chelator desferrioxamine (DFO) in concert led to an increase in steady-state MMP-1 mRNA levels, possibly dependent on intracellular H2O2 increase.	Iron	211-215	interleukin 1 alpha	Homo sapiens	0-19
31287995-0	2019	Liver-Specific, but Not Retina-Specific, Hepcidin Knockout Causes Retinal Iron Accumulation and Degeneration.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	41-49
31287995-1	2019	The liver secretes hepcidin (Hepc) into the bloodstream to reduce blood iron levels.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	19-27
31287995-1	2019	The liver secretes hepcidin (Hepc) into the bloodstream to reduce blood iron levels.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	29-33
31287995-2	2019	Hepc accomplishes this by triggering degradation of the only known cellular iron exporter ferroportin in the gut, macrophages, and liver.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	0-4
9119254-8	1997	In addition, by co-incubation of HepG2 cells with rat liver microsomes, it was observed that the GGT owned by HepG2 cells can act extracellularly, as a stimulant on the GSH- and iron-dependent lipid peroxidation of microsomes.	Iron	178-182	gamma-glutamyltransferase 1	Rattus norvegicus	97-100
31287995-3	2019	We previously demonstrated that systemic Hepc knockout (HepcKO) mice, which have high serum iron, develop retinal iron overload and degeneration.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	41-45
31287995-3	2019	We previously demonstrated that systemic Hepc knockout (HepcKO) mice, which have high serum iron, develop retinal iron overload and degeneration.	Iron	114-118	hepcidin antimicrobial peptide	Mus musculus	41-45
31287995-4	2019	However, it was unclear whether this is caused by high blood iron levels or, alternatively, retinal iron influx that would normally be regulated by retina-produced Hepc.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	164-168
9411071-1	1997	Under iron-restricted conditions staphylococcal strains could utilize in vitro several animals body iron sources in form of bovine haemoglobin, hemin, lactoferrin and transferrin, ovotransferrin, horse myoglobin ferritin and cytochrome C.	Iron	6-10	lactotransferrin	Bos taurus	151-162
31207573-6	2019	Moreover, the synergetic effect of Fe, Cu and D407 in the composite Fe-Cu/D407 were well investigated for the first time according to the analyses of TPR, XPS and EIS.	Iron	35-37	translocated promoter region, nuclear basket protein	Homo sapiens	150-153
31207573-6	2019	Moreover, the synergetic effect of Fe, Cu and D407 in the composite Fe-Cu/D407 were well investigated for the first time according to the analyses of TPR, XPS and EIS.	Iron	68-70	translocated promoter region, nuclear basket protein	Homo sapiens	150-153
8973193-4	1996	Comparative studies of the spectral interaction and inhibitory effects of twelve compounds related to 1 with CYP 2C9 showed that the aniline function of 1 is responsible for the formation of the iron-nitrogen bond of the 429 nm-absorbing complex and is necessary for the inhibitory effects of 1.	Iron	195-199	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	109-116
31463593-6	2019	Our results reveal the asymmetric functional roles of the Dph1-Dph2 heterodimer and may help to understand how the Fe-S clusters in radical SAM enzymes are reduced in biology.	Iron	115-119	diphthamide biosynthesis 1	Homo sapiens	58-62
31493153-7	2019	Loss of either cysteine in the Aft2 iron-sulfur binding site may disrupt this ligand-exchange process leading to the isolation of a trapped Aft2-Grx3-Bol2 intermediate, while the replacement of both cysteines abrogates both the iron-sulfur cluster exchange and the protein-protein interactions between Aft2 and Grx3-Bol2.	Iron	228-232	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	145-149
8973193-6	1996	A model for the binding of 1 in the CYP 2C9 active site is proposed; that takes into account three major interactions that should be at the origin of the high-affinity and specific inhibitory effects of 1 toward CYP 2C9: (i) the binding of its nitrogen atom to CYP 2C9 iron, (ii) an ionic interaction of its SO2N- anionic site with a cationic residue of CYP 2C9, and (iii) an interaction of its N-phenyl group with an hydrophobic part of the protein active site.	Iron	269-273	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	36-43
31799961-2	2019	This paper investigated the hydrophobicity and iron coagulation of extracellular polymeric substances (EPSs) from colonial Microcystis in order to understand the impact of EPS on the water treatment process.	Iron	47-51	14-3-3epsilon	Drosophila melanogaster	103-106
8973193-6	1996	A model for the binding of 1 in the CYP 2C9 active site is proposed; that takes into account three major interactions that should be at the origin of the high-affinity and specific inhibitory effects of 1 toward CYP 2C9: (i) the binding of its nitrogen atom to CYP 2C9 iron, (ii) an ionic interaction of its SO2N- anionic site with a cationic residue of CYP 2C9, and (iii) an interaction of its N-phenyl group with an hydrophobic part of the protein active site.	Iron	269-273	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	212-219
8973193-6	1996	A model for the binding of 1 in the CYP 2C9 active site is proposed; that takes into account three major interactions that should be at the origin of the high-affinity and specific inhibitory effects of 1 toward CYP 2C9: (i) the binding of its nitrogen atom to CYP 2C9 iron, (ii) an ionic interaction of its SO2N- anionic site with a cationic residue of CYP 2C9, and (iii) an interaction of its N-phenyl group with an hydrophobic part of the protein active site.	Iron	269-273	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	212-219
31270208-0	2019	Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	85-93
8973193-6	1996	A model for the binding of 1 in the CYP 2C9 active site is proposed; that takes into account three major interactions that should be at the origin of the high-affinity and specific inhibitory effects of 1 toward CYP 2C9: (i) the binding of its nitrogen atom to CYP 2C9 iron, (ii) an ionic interaction of its SO2N- anionic site with a cationic residue of CYP 2C9, and (iii) an interaction of its N-phenyl group with an hydrophobic part of the protein active site.	Iron	269-273	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	212-219
31270208-0	2019	Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms.	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	85-93
8955336-0	1996	Post-transcriptional regulation of plant ferritin accumulation in response to iron as observed in the maize mutant ys1.	Iron	78-82	iron-phytosiderophore transporter yellow stripe 1	Zea mays	115-118
31265757-5	2019	Mechanistic studies (kinetic poisoning, X-ray absorption spectroscopy, TEM) strongly indicate the operation of small iron clusters and particle catalysts.	Iron	117-121	MFT2	Homo sapiens	71-74
8955336-1	1996	The maize mutant ys1 accumulates iron in leaves to a lower extent than a Fe-efficient genotype.	Iron	33-37	iron-phytosiderophore transporter yellow stripe 1	Zea mays	17-20
8916957-3	1996	Since FES contains the consensus motifs for PI3 kinase binding, we tested the possibility that FES may associate with PI3 kinase upon IL-4 stimulation.	Iron	95-98	interleukin 4	Mus musculus	134-138
31361291-1	2019	Synergistic cancer starvation/ROS-mediated/chemo-therapy is developed through a cascade reaction with enzyme glucose oxidase (GOX) modified on the surface of an Fe-based metal organic framework (MOF(Fe)) and drug camptothecin (CPT) loaded into the cavities of MOF(Fe).	Iron	161-163	hydroxyacid oxidase 1	Homo sapiens	109-124
31361291-1	2019	Synergistic cancer starvation/ROS-mediated/chemo-therapy is developed through a cascade reaction with enzyme glucose oxidase (GOX) modified on the surface of an Fe-based metal organic framework (MOF(Fe)) and drug camptothecin (CPT) loaded into the cavities of MOF(Fe).	Iron	161-163	hydroxyacid oxidase 1	Homo sapiens	126-129
31361291-1	2019	Synergistic cancer starvation/ROS-mediated/chemo-therapy is developed through a cascade reaction with enzyme glucose oxidase (GOX) modified on the surface of an Fe-based metal organic framework (MOF(Fe)) and drug camptothecin (CPT) loaded into the cavities of MOF(Fe).	Iron	199-201	hydroxyacid oxidase 1	Homo sapiens	109-124
11666769-1	1996	Low-temperature single-crystal Raman spectra for RbM(III)(SO(4))(2).12H(2)O (M(III) = Al, Ga, In, Ti, V, Cr, Fe) and RbM(III)(SO(4))(2).12D(2)O (M(III) = Al, V) have been collected and assigned in the range 275-1200 cm(-)(1).	Iron	109-111	RNA binding motif protein Y-linked family 2 member D, pseudogene	Homo sapiens	49-52
31361291-1	2019	Synergistic cancer starvation/ROS-mediated/chemo-therapy is developed through a cascade reaction with enzyme glucose oxidase (GOX) modified on the surface of an Fe-based metal organic framework (MOF(Fe)) and drug camptothecin (CPT) loaded into the cavities of MOF(Fe).	Iron	199-201	hydroxyacid oxidase 1	Homo sapiens	126-129
31287655-2	2019	We screened a set of clinically used iron chelators and report that they potently inhibit JMJD2A (KDM4A) in vitro.	Iron	37-41	lysine demethylase 4A	Homo sapiens	98-103
8784198-0	1996	The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters.	Iron	35-39	thioredoxin	Homo sapiens	77-88
31405213-6	2019	hNgb binds to proteins of the cellular iron metabolism (e.g., RPL15 and PCBP3) in an unstressed condition and shows an elevated binding ratio towards cell death-linked proteins, such as HNRNPA3, FAM120A, and ABRAXAS2, under ferroptotic stress.	Iron	39-43	neuroglobin	Homo sapiens	0-4
8784198-0	1996	The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters.	Iron	126-130	thioredoxin	Homo sapiens	77-88
31305986-2	2019	Here, non-noble-metal graphene-like carbon nanosheets with trapped Fe species (Fe-N/GPC) are developed by an iron-salt thermally emitted strategy, which integrates the modulation of the electronic structure for boosted intrinsic activity with the engineering of hierarchical porosity for enriched active sites.	Iron	67-69	glycophorin C (Gerbich blood group)	Homo sapiens	84-87
31305986-2	2019	Here, non-noble-metal graphene-like carbon nanosheets with trapped Fe species (Fe-N/GPC) are developed by an iron-salt thermally emitted strategy, which integrates the modulation of the electronic structure for boosted intrinsic activity with the engineering of hierarchical porosity for enriched active sites.	Iron	109-113	glycophorin C (Gerbich blood group)	Homo sapiens	84-87
8784198-1	1996	Thioredoxin reduction in chloroplasts is catalyzed by a unique class of disulfide reductases which use a [2Fe-2S]2+/+ ferredoxin as the electron donor and contain an Fe-S cluster as the sole prosthetic group in addition to the active-site disulfide.	Iron	166-170	thioredoxin	Homo sapiens	0-11
31305986-3	2019	The ORR electrocatalytic performance of Fe-N/GPC-800 achieves the half-wave potentials of 0.86 and 0.77 V with limiting current densities of 6.1 and 4.7 mA cm-2 in 0.1 M KOH and 0.1 M PBS solutions, respectively, as well as respectable stability.	Iron	40-44	glycophorin C (Gerbich blood group)	Homo sapiens	45-48
31305986-4	2019	Furthermore, Fe-N/GPC-800 also shows considerable ORR catalytic activity in acid media accompanied by stability superior to those of Pt/C catalysts.	Iron	13-17	glycophorin C (Gerbich blood group)	Homo sapiens	18-21
31305986-5	2019	The as-prepared Fe-N/GPC-800, as a cathodic catalyst, is assessed in a Zn-air battery test and delivers an open-circuit voltage of 1.44 V with a power density of 134 mW cm-2 as well as the outstanding durability after 350 cycles at 10 mA cm-2, demonstrating appreciable promise in application of metal-air batteries.	Iron	16-20	glycophorin C (Gerbich blood group)	Homo sapiens	21-24
8784198-2	1996	The nature, properties, and function of the Fe-S cluster in spinach ferredoxin:thioredoxin reductase (FTR) have been investigated by the combination of UV/visible absorption, variable-temperature magnetic circular dichroism (MCD), EPR, and resonance Raman (RR) spectroscopies.	Iron	44-48	thioredoxin	Homo sapiens	79-90
8828436-1	1996	OBJECTIVE: The concerted iron-binding antioxidant activity of transferrin and ceruloplasmin decreases with increasing transferrin saturation by iron.	Iron	25-29	ceruloplasmin	Homo sapiens	78-91
31048253-0	2019	Colorimetric detection of blood glucose based on GOx@ZIF-8@Fe-polydopamine cascade reaction.	Iron	59-61	hydroxyacid oxidase 1	Homo sapiens	49-52
31048253-6	2019	The ZIF-8@Fe-PDA hybrid shell protected the INAzymes nanostructure from degradation under acidic conditions, which results in good chemical stability of the GOx@ZIF-8@Fe-PDA.	Iron	10-12	hydroxyacid oxidase 1	Homo sapiens	157-160
8828436-1	1996	OBJECTIVE: The concerted iron-binding antioxidant activity of transferrin and ceruloplasmin decreases with increasing transferrin saturation by iron.	Iron	144-148	ceruloplasmin	Homo sapiens	78-91
31188032-0	2019	Renal iron accelerates the progression of diabetic nephropathy in the HFE gene knockout mouse model of iron overload.	Iron	6-10	homeostatic iron regulator	Mus musculus	70-73
8872953-13	1996	Iron chelation therapy (deferoxamine) mitigated myoglobin-induced cell killing.	Iron	0-4	myoglobin	Homo sapiens	48-57
31188032-0	2019	Renal iron accelerates the progression of diabetic nephropathy in the HFE gene knockout mouse model of iron overload.	Iron	103-107	homeostatic iron regulator	Mus musculus	70-73
8754685-6	1996	Roots of man1 mutants also accumulated metals, but unlike leaves they accumulated 10-fold more total Fe (symplasmic and apoplasmic combined) than wild-type roots.	Iron	101-103	Glycosyl hydrolase superfamily protein	Arabidopsis thaliana	9-13
31088840-2	2019	Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor"s responses to changes in oxygen, iron, nutrient, or energy levels.	Iron	144-148	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	81-85
31447555-5	2019	NAC can effectively mitigate iron-induced oxidative injury of cardiomyocytes, evidenced by reduced production of MDA, 8-iso-PGF2alpha, and 8-OHDG and maintained concentrations of SOD, CAT, GSH-Px, and GSH in ELISA and biochemical tests; downregulated expression of CHOP, GRP78, p62, and LC3-II proteins in Western Blot, and less cardiomyocytes apoptosis in flow cytometric analysis.	Iron	29-33	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	271-276
8679672-5	1996	Comparison of the long-range NOEs of Im-cyt c relative to the crystal structure of native cytochrome c reveals apparent conformational changes of some side-chains especially those close to heme pocket within the N- and C-terminal helices resulting from the binding of imidazole to iron by displacing native Met-80 side-chain.	Iron	281-285	cytochrome c, somatic	Equus caballus	90-102
31329045-10	2019	The in vivo functional role of Fth was illustrated with Fth+/- mice, which incorporated less iron into their dental epithelium and exhibited poor enamel quality.	Iron	93-97	ferritin heavy polypeptide 1	Mus musculus	31-34
31329045-10	2019	The in vivo functional role of Fth was illustrated with Fth+/- mice, which incorporated less iron into their dental epithelium and exhibited poor enamel quality.	Iron	93-97	ferritin heavy polypeptide 1	Mus musculus	56-59
31332290-1	2019	p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2).	Iron	82-86	iron responsive element binding protein 2	Mus musculus	102-127
15157460-4	1996	Specifically, iron uptake by the cell-surface GPI-linked traps ferrin homologue, melanotransferrin or p97, is described and possible functions of this traps ferrin-independent pathway are proposed.	Iron	14-18	melanotransferrin	Homo sapiens	81-98
31332290-1	2019	p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2).	Iron	82-86	iron responsive element binding protein 2	Mus musculus	129-133
31065779-2	2019	The Arabidopsis thaliana mitochondrial cysteine desulfurase AtNFS1 has an essential role in cellular ISC Fe-S cluster assembly, and this pathway is one of the main sinks for iron (Fe) and sulfur (S) in the plant.	Iron	174-178	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	60-66
31065779-2	2019	The Arabidopsis thaliana mitochondrial cysteine desulfurase AtNFS1 has an essential role in cellular ISC Fe-S cluster assembly, and this pathway is one of the main sinks for iron (Fe) and sulfur (S) in the plant.	Iron	105-107	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	60-66
31229404-1	2019	The iron-sensing protein FBXL5 is the substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradation of iron regulatory proteins (IRPs).	Iron	4-8	ring-box 1	Homo sapiens	72-76
31337415-9	2019	ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.	Iron	37-41	ferritin heavy polypeptide 1	Mus musculus	129-133
31115467-0	2019	NRAMP1 promotes iron uptake at the late stage of iron deficiency in poplars.	Iron	16-20	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	0-6
31115467-8	2019	IRT1 and NRAMP1 are both Fe2+ transporters for iron uptake in Arabidopsis.	Iron	47-51	iron-regulated transporter 1	Arabidopsis thaliana	0-4
31115467-8	2019	IRT1 and NRAMP1 are both Fe2+ transporters for iron uptake in Arabidopsis.	Iron	47-51	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	9-15
31233037-4	2019	A western blot analysis showed that an iron/fat-enriched diet triggered testicular endoplasmic reticular (ER) stress but decreased mitochondrion biogenesis proteins (PGC1alpha and TFAM) and T-converting proteins (StAR, CYP11A, and 17beta-HSD).	Iron	39-43	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	219-225
31187614-2	2019	Here, we report a metallic Fe (iron)-Au (gold) BNW-based platform for capturing CD8 T cells and the interferon-gamma (gamma) they secrete, both of which play key roles in controlling infectious diseases such as tuberculosis, at the single-cell level.	Iron	27-29	CD8a molecule	Homo sapiens	80-83
31295319-1	2019	Hepcidin is an iron regulatory peptide hormone that is secreted from hepatocytes and inhibits iron efflux from tissues to plasma.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	0-8
31413749-10	2019	Furthermore, loss-of-function studies determined that BOLA2 plays critical roles in promoting iron overload, tumor growth and TH.	Iron	94-98	bolA family member 2	Homo sapiens	54-59
31854712-5	2019	With rearranged structural defects, photo-generated electrons were prone to transfer from the surface of P25 to Fe-POM nanoparticles.	Iron	112-118	tubulin polymerization promoting protein	Homo sapiens	105-108
31270335-5	2019	We show that iron is essential for B cell proliferation; both iron deficiency and alpha-ketoglutarate inhibition could suppress cyclin E1 induction and S phase entry of B cells upon activation.	Iron	13-17	cyclin E1	Homo sapiens	128-137
31312208-2	2019	The oxidation kinetics of the two phyllosemiquinones by the iron-sulfur cluster FX differ by approximately one order of magnitude, with  A 1 A  -   being oxidized in about 200 ns and  A 1 B  -   in about 20 ns.	Iron	60-64	alpha-1-B glycoprotein	Homo sapiens	184-189
31132316-0	2019	Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype.	Iron	14-18	homeostatic iron regulator	Mus musculus	40-43
31132316-1	2019	HFE-hemochromatosis is a disease characterized by a systemic iron overload phenotype mainly associated with mutations in the HFE protein (HFE) gene.	Iron	61-65	homeostatic iron regulator	Mus musculus	0-3
31132316-1	2019	HFE-hemochromatosis is a disease characterized by a systemic iron overload phenotype mainly associated with mutations in the HFE protein (HFE) gene.	Iron	61-65	homeostatic iron regulator	Mus musculus	125-128
31132316-4	2019	Our data provide evidence that both wt- and Hfe-KO-derived chondrocytes, when exposed to 50 muM iron, develop characteristics of an OA-related phenotype, such as an increased expression of metalloproteases, a decreased extracellular matrix production, and a lower expression level of aggrecan.	Iron	96-100	homeostatic iron regulator	Mus musculus	44-47
31132316-5	2019	In addition, Hfe-KO cells also showed an increased expression of iron metabolism markers and MMP3, indicating an increased susceptibility to intracellular iron accumulation and higher levels of chondrocyte catabolism.	Iron	65-69	homeostatic iron regulator	Mus musculus	13-16
31132316-5	2019	In addition, Hfe-KO cells also showed an increased expression of iron metabolism markers and MMP3, indicating an increased susceptibility to intracellular iron accumulation and higher levels of chondrocyte catabolism.	Iron	155-159	homeostatic iron regulator	Mus musculus	13-16
31132316-6	2019	Accordingly, upon treatment with 50 muM iron, these chondrocytes were found to preferentially differentiate toward hypertrophy with increased expression of collagen I and transferrin and downregulation of SRY (sex-determining region Y)-box containing gene 9 (Sox9).	Iron	40-44	transferrin	Mus musculus	171-182
31132316-7	2019	In conclusion, high iron exposure can compromise chondrocyte metabolism, which, when simultaneously affected by an Hfe loss of function, appears to be more susceptible to the establishment of an OA-related phenotype.	Iron	20-24	homeostatic iron regulator	Mus musculus	115-118
31943995-1	2019	An oxalate-bridged binuclear iron(III) ionic liquid combined with an imidazolium based cation, (dimim)2 [Fe2 Cl4 (mu-ox)], was synthesized and characterized by a wide range of techniques.	Iron	29-38	endogenous retrovirus group W member 3	Homo sapiens	109-112
30660752-6	2019	Rim2-dependent iron transport was unaffected by pyrimidine nucleotides.	Iron	15-19	regulating synaptic membrane exocytosis 2	Homo sapiens	0-4
31040174-0	2019	Calcium-Promoted Interaction between the C2-Domain Protein EHB1 and Metal Transporter IRT1 Inhibits Arabidopsis Iron Acquisition.	Iron	112-116	iron-regulated transporter 1	Arabidopsis thaliana	86-90
31040174-2	2019	Maintaining the balance of optimal iron availability in the model plant Arabidopsis (Arabidopsis thaliana) requires the precise operation of iron import through the principal iron transporter IRON-REGULATED TRANSPORTER1 (IRT1).	Iron	35-39	iron-regulated transporter 1	Arabidopsis thaliana	192-219
31040174-2	2019	Maintaining the balance of optimal iron availability in the model plant Arabidopsis (Arabidopsis thaliana) requires the precise operation of iron import through the principal iron transporter IRON-REGULATED TRANSPORTER1 (IRT1).	Iron	35-39	iron-regulated transporter 1	Arabidopsis thaliana	221-225
31040174-2	2019	Maintaining the balance of optimal iron availability in the model plant Arabidopsis (Arabidopsis thaliana) requires the precise operation of iron import through the principal iron transporter IRON-REGULATED TRANSPORTER1 (IRT1).	Iron	141-145	iron-regulated transporter 1	Arabidopsis thaliana	192-219
31040174-2	2019	Maintaining the balance of optimal iron availability in the model plant Arabidopsis (Arabidopsis thaliana) requires the precise operation of iron import through the principal iron transporter IRON-REGULATED TRANSPORTER1 (IRT1).	Iron	141-145	iron-regulated transporter 1	Arabidopsis thaliana	221-225
31040174-9	2019	The presence of EHB1 prevented the IRT1-mediated complementation of iron-deficient fet3fet4 yeast (Saccharomyces cerevisiae).	Iron	68-72	iron-regulated transporter 1	Arabidopsis thaliana	35-39
31040174-10	2019	Our data suggest that EHB1 acts as a direct inhibitor of IRT1-mediated iron import into the cell.	Iron	71-75	iron-regulated transporter 1	Arabidopsis thaliana	57-61
31316498-4	2019	In this study, we investigated whether iron (in the form of Fe3+ and hemin) might modulate 5-LOX influencing its membrane binding, subcellular distribution, and functional activity.	Iron	39-43	lysyl oxidase	Homo sapiens	93-96
31316498-6	2019	To ascertain whether iron can modulate the subcellular distribution of 5-LOX in immune cells, we exposed THP-1 macrophages and human primary macrophages to exogenous iron.	Iron	21-25	lysyl oxidase	Homo sapiens	73-76
31061094-0	2019	Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions.	Iron	0-4	nuclear receptor coactivator 4	Homo sapiens	16-21
31061094-4	2019	In this study, we show that the inhibition of lysosome-dependent protein degradation by bafilomycin A1 and the knockdown of NCOA4, an autophagic receptor for ferritin, reduced mitochondrial respiration, respiratory chain complex assembly, and membrane potential under iron-sufficient conditions.	Iron	268-272	nuclear receptor coactivator 4	Homo sapiens	124-129
31239406-3	2019	The Lgr5-EGFP-IRES-creERT mice were exposed to 50 cGy of iron radiation.	Iron	57-61	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	4-8
31322366-1	2019	Spin waves are investigated in yttrium iron garnet waveguides with a thickness of 39 nm and widths ranging down to 50 nm, i.e., with an aspect ratio thickness over width approaching unity, using Brillouin light scattering spectroscopy.	Iron	39-43	spindlin 1	Homo sapiens	0-4
31040179-5	2019	The mitochondrial biosynthesis of (Fe-S)int required ISC components such as Nfs1 cysteine desulfurase, Isu1/2 scaffold, and Ssq1 chaperone.	Iron	35-39	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	103-109
31244673-0	2019	Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype.	Iron	49-53	actinin alpha 3	Homo sapiens	98-103
31244673-3	2019	Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on hematological and iron metabolism response induced by marathon race.	Iron	108-112	actinin alpha 3	Homo sapiens	67-72
30988031-8	2019	Moreover, we found that a third component, TonB1, a protein involved in iron transport in P. aeruginosa, working together with FiuA and the ExbB/ExbD complex, was directly implicated in this discrimination.IMPORTANCE Bacterial antibiotic resistance constitutes a threat to human health, imposing the need for identification of new targets and development of new strategies to fight multiresistant pathogens.	Iron	72-76	ferrichrome receptor FiuA	Pseudomonas aeruginosa PAO1	127-131
31244655-3	2019	In sepsis, hepcidin induces iron sequestration to limit iron availability to pathogens.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	11-19
31244655-3	2019	In sepsis, hepcidin induces iron sequestration to limit iron availability to pathogens.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	11-19
15157460-4	1996	Specifically, iron uptake by the cell-surface GPI-linked traps ferrin homologue, melanotransferrin or p97, is described and possible functions of this traps ferrin-independent pathway are proposed.	Iron	14-18	melanotransferrin	Homo sapiens	102-105
31034107-1	2019	Using ultrafast optical absorption spectroscopy, the room-temperature spin-state switching dynamics induced by a femtosecond laser pulse in high-quality thin films of the molecular spin-crossover (SCO) complex [Fe(HB(tz)3 )2 ] (tz = 1,2,4-triazol-1-yl) are studied.	Iron	211-213	spindlin 1	Homo sapiens	70-74
31034107-1	2019	Using ultrafast optical absorption spectroscopy, the room-temperature spin-state switching dynamics induced by a femtosecond laser pulse in high-quality thin films of the molecular spin-crossover (SCO) complex [Fe(HB(tz)3 )2 ] (tz = 1,2,4-triazol-1-yl) are studied.	Iron	211-213	spindlin 1	Homo sapiens	181-185
8647250-4	1996	Furthermore, possible binding sites for cytochrome b5, the substrate CMP-Neu5Ac and a mononuclear iron centre were also identified.	Iron	98-102	cytochrome b5 type A	Homo sapiens	40-53
30968250-5	2019	The literature review revealed that most published interaction studies have been candidate gene studies, causing observed interactions to cluster in a few genes related to detoxification (GSTM1 and GSTT1), inflammation (IL-6), iron processing (HFE), and microRNA processing (GEMIN4 and DGCR8).	Iron	227-231	DGCR8 microprocessor complex subunit	Homo sapiens	286-291
31172012-4	2019	More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds.	Iron	134-138	Cad1p	Saccharomyces cerevisiae S288C	58-62
8619873-2	1996	Binding of the iron regulatory protein (IRP) to the IRE, in response to decreases in cellular iron levels, leads to a block in translation of these mRNAs.	Iron	15-19	Iron regulatory protein 1B	Drosophila melanogaster	40-43
31172012-4	2019	More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds.	Iron	134-138	Cad1p	Saccharomyces cerevisiae S288C	63-67
31172012-4	2019	More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds.	Iron	134-138	Cin5p	Saccharomyces cerevisiae S288C	83-87
31172012-4	2019	More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds.	Iron	134-138	Cin5p	Saccharomyces cerevisiae S288C	88-92
31056903-4	2019	Iron reduced micellization by precipitating bile salts from solution and ferulic acid and catechin by inhibition of pancreatic lipase.	Iron	0-4	pancreatic lipase	Homo sapiens	116-133
8661994-1	1996	Ferritin, a protein widespread in nature, concentrates iron approximately 10(11)-10(12)-fold above the solubility within a spherical shell of 24 subunits; it derives in plants and animals from a common ancestor (based on sequence) but displays a cytoplasmic location in animals compared to the plastid in contemporary plants.	Iron	55-59	ferritin-1, chloroplastic	Glycine max	0-8
31193082-9	2019	As a compensatory response, the diet caused elevation of serum hepcidin, which accelerates excretion of iron from the body.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	63-71
8661994-2	1996	Ferritin gene regulation in plants and animals is altered by development, hormones, and excess iron; iron signals target DNA in plants but mRNA in animals.	Iron	95-99	ferritin-1, chloroplastic	Glycine max	0-8
8661994-2	1996	Ferritin gene regulation in plants and animals is altered by development, hormones, and excess iron; iron signals target DNA in plants but mRNA in animals.	Iron	101-105	ferritin-1, chloroplastic	Glycine max	0-8
8661994-4	1996	Comparison of ferritin gene organization in plants and animals, made possible by the cloning of a dicot (soybean) ferritin gene presented here and the recent cloning of two monocot (maize) ferritin genes, shows evolutionary divergence in ferritin gene organization between plants and animals but conservation among plants or among animals; divergence in the genetic mechanism for iron regulation is reflected by the absence in all three plant genes of the IRE, a highly conserved, noncoding sequence in vertebrate animal ferritin mRNA.	Iron	380-384	ferritin-1, chloroplastic	Glycine max	14-22
31041303-4	2019	For example, Fe/N-doped graphitic SACs have exhibited spin-state dependent reactivity that remains poorly understood.	Iron	13-15	spindlin 1	Homo sapiens	54-58
8609608-5	1996	These results indicate that, at neutral pH, the ligation of His18 of the iron is important for the maintenance of the native structure whereas the Met80 ligation is not essential, and that porphyrin-cytochrome c assumes a molten globule-like state.	Iron	73-77	cytochrome c, somatic	Equus caballus	199-211
8619831-0	1996	Oxidative stress response in iron-induced acute nephrotoxicity: enhanced expression of heat shock protein 90.	Iron	29-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-108
30858027-4	2019	Further molecular docking studies revealed that the compound 19a formed a coordinate bond with the heme iron through the carboxylic acid moiety.	Iron	104-108	SLAM family member 7	Homo sapiens	61-64
8779981-11	1996	The inhibitory effect of iron-loaded RLF on alpha-SMA expression suggests that tissue ferritin does not initiate lipocyte activation in iron overload, but rather may have a suppressive action on this process.	Iron	25-29	actin gamma 2, smooth muscle	Rattus norvegicus	44-53
30782844-2	2019	The host response against these types of infections includes the release of epithelial-derived antimicrobial factors such as lipocalin-2 (LCN-2), a protein that specifically inhibits the iron acquisition of Enterobacteriaceae by binding and neutralizing the bacterial iron-scavenging molecule enterobactin.	Iron	187-191	lipocalin 2	Homo sapiens	125-136
30782844-2	2019	The host response against these types of infections includes the release of epithelial-derived antimicrobial factors such as lipocalin-2 (LCN-2), a protein that specifically inhibits the iron acquisition of Enterobacteriaceae by binding and neutralizing the bacterial iron-scavenging molecule enterobactin.	Iron	187-191	lipocalin 2	Homo sapiens	138-143
30782844-2	2019	The host response against these types of infections includes the release of epithelial-derived antimicrobial factors such as lipocalin-2 (LCN-2), a protein that specifically inhibits the iron acquisition of Enterobacteriaceae by binding and neutralizing the bacterial iron-scavenging molecule enterobactin.	Iron	268-272	lipocalin 2	Homo sapiens	125-136
30782844-2	2019	The host response against these types of infections includes the release of epithelial-derived antimicrobial factors such as lipocalin-2 (LCN-2), a protein that specifically inhibits the iron acquisition of Enterobacteriaceae by binding and neutralizing the bacterial iron-scavenging molecule enterobactin.	Iron	268-272	lipocalin 2	Homo sapiens	138-143
30958854-1	2019	Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	14-22
8561510-9	1996	Transferrin receptor mRNA expression in liver was induced as soon as iron levels decreased early in scurvy, which is similar to results reported for iron-depleted cultured cells.	Iron	69-73	inhibitor of carbonic anhydrase	Cavia porcellus	0-11
30958854-1	2019	Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency.	Iron	81-85	hepcidin antimicrobial peptide	Mus musculus	14-22
30958854-4	2019	Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	79-87
30958854-4	2019	Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	225-233
30958854-4	2019	Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA.	Iron	179-183	hepcidin antimicrobial peptide	Mus musculus	225-233
30610899-7	2019	Western blot analysis showed that isocitrate dehydrogenase 3 (IDH3), succinate dehydrogenase (SDH) and malate dehydrogenase 2 (MDH2) were markedly decreased both in these two aging models, whereas the iron-sulfur cluster assembly enzyme (ISCU) was up-regulated in the naturally occurring senescent astrocytes but was down-regulated in the d-gal-induced senescent astrocytes.	Iron	201-205	malate dehydrogenase 2	Homo sapiens	127-131
8561510-9	1996	Transferrin receptor mRNA expression in liver was induced as soon as iron levels decreased early in scurvy, which is similar to results reported for iron-depleted cultured cells.	Iron	149-153	inhibitor of carbonic anhydrase	Cavia porcellus	0-11
8907170-8	1996	103, 4912-4921], the anti-Curie behavior observed for the heme methyl proton resonance in met-cyano cytochrome c is attributed to a rotational displacement of the heme about the iron-His bond relative to the protein moiety due to a temperature-dependent conformational alteration of the heme-protein linkage.	Iron	178-182	cytochrome c, somatic	Equus caballus	100-112
30615967-3	2019	The antioxidant properties of EGCG-modified beta-lg was assessed using DPPH radical scavenging activity, iron chelating ability, and inhibition of Cu2+-induced LDL oxidation.	Iron	105-109	beta-lactoglobulin	Bos taurus	44-51
30860817-4	2019	Magnetic studies identified gradual and half-complete thermal spin crossover in the tetranuclear grid 1, where 50% of ferrous atoms exhibit thermal as well as photoinduced spin state switching and the remaining half of iron(II) centers are permanently blocked in their high-spin state.	Iron	219-223	spindlin 1	Homo sapiens	62-66
8597165-7	1995	We propose that it is catalyzed by ceruloplasmin, the copper-containing ferroxidase that loads iron into transferrin.	Iron	95-99	ceruloplasmin	Homo sapiens	35-48
30860817-6	2019	Analysis of the magnetic data reveals the zero-field splitting parameter   D    6-8 cm-1 with a large rhombicity for all high-spin iron(II) atoms in 1 or 2.	Iron	131-135	spindlin 1	Homo sapiens	126-130
30996438-9	2019	The iron dialysability of 3-15 mM composite pasta was similar to the NaFeEDTA fortified pasta.	Iron	4-8	solute carrier family 45, member 1	Rattus norvegicus	44-49
30996438-10	2019	The iron bioavailability (in vivo) of 15 mM group based pasta was evaluated in the anemic rats.	Iron	4-8	solute carrier family 45, member 1	Rattus norvegicus	56-61
30996438-11	2019	The pasta at 4% (Fe 0.026 mg/g) in iron-deficient diet fed to anemic rats for 2 weeks showed percentage iron absorption (PIA) and hemoglobin regeneration efficiency (HRE) of 85.3% and 44.4% respectively which is higher than the NaFeEDTA.	Iron	17-19	solute carrier family 45, member 1	Rattus norvegicus	4-9
8597165-9	1995	We load iron into ferritin with ceruloplasmin so ferritin plus ceruloplasmin is an effective "antioxidant".	Iron	8-12	ceruloplasmin	Homo sapiens	32-45
30996438-11	2019	The pasta at 4% (Fe 0.026 mg/g) in iron-deficient diet fed to anemic rats for 2 weeks showed percentage iron absorption (PIA) and hemoglobin regeneration efficiency (HRE) of 85.3% and 44.4% respectively which is higher than the NaFeEDTA.	Iron	35-39	solute carrier family 45, member 1	Rattus norvegicus	4-9
8597165-9	1995	We load iron into ferritin with ceruloplasmin so ferritin plus ceruloplasmin is an effective "antioxidant".	Iron	8-12	ceruloplasmin	Homo sapiens	63-76
30996438-11	2019	The pasta at 4% (Fe 0.026 mg/g) in iron-deficient diet fed to anemic rats for 2 weeks showed percentage iron absorption (PIA) and hemoglobin regeneration efficiency (HRE) of 85.3% and 44.4% respectively which is higher than the NaFeEDTA.	Iron	104-108	solute carrier family 45, member 1	Rattus norvegicus	4-9
30996438-12	2019	In conclusion, iron-fortified pasta is the promising food fortificant with more iron bioavailability in the prevention of iron deficiency anemia.	Iron	15-19	solute carrier family 45, member 1	Rattus norvegicus	30-35
7488192-0	1995	Structural organization and chromosomal localization of the human nuclear gene (NDUFV2) for the 24-kDa iron-sulfur subunit of complex I in mitochondrial respiratory chain.	Iron	103-107	NADH:ubiquinone oxidoreductase core subunit V2	Homo sapiens	80-86
30996438-12	2019	In conclusion, iron-fortified pasta is the promising food fortificant with more iron bioavailability in the prevention of iron deficiency anemia.	Iron	80-84	solute carrier family 45, member 1	Rattus norvegicus	30-35
30714148-4	2019	These include (i) kinase-mediated necroptosis, which depends on receptor interacting protein kinase 3 (RIPK3)-mediated phosphorylation of the pseudokinase mixed lineage kinase domain like (MLKL); (ii) gasdermin-mediated necrosis downstream of inflammasomes, also referred to as pyroptosis; and (iii) an iron-catalysed mechanism of highly specific lipid peroxidation named ferroptosis.	Iron	303-307	receptor interacting serine/threonine kinase 3	Homo sapiens	64-101
7500944-11	1995	Our results are consistent with a pathway leading from chorismate to isochorismate and then to salicylate plus pyruvate, catalyzed consecutively by the iron-repressible PchA and PchB proteins in P. aeruginosa.	Iron	152-156	salicylate biosynthesis isochorismate synthase	Pseudomonas aeruginosa PAO1	169-173
30714148-4	2019	These include (i) kinase-mediated necroptosis, which depends on receptor interacting protein kinase 3 (RIPK3)-mediated phosphorylation of the pseudokinase mixed lineage kinase domain like (MLKL); (ii) gasdermin-mediated necrosis downstream of inflammasomes, also referred to as pyroptosis; and (iii) an iron-catalysed mechanism of highly specific lipid peroxidation named ferroptosis.	Iron	303-307	receptor interacting serine/threonine kinase 3	Homo sapiens	103-108
30963028-8	2019	Results: WES revealed gene variants involved in iron absorption and transport, in the transmembrane protease, serine 6 (TMPRSS6) and transferrin (TF) genes; multiple genetic variants in CUBN, which encodes cubilin (a receptor involved in the absorption of vitamin B12 as well as the reabsorption of transferrin-bound iron and vitamin D in the kidneys); SLC25A37 (involved in iron transport into mitochondria) and CD163 (a scavenger receptor involved in hemorrhage resolution).	Iron	317-321	cubilin	Homo sapiens	206-213
30963028-8	2019	Results: WES revealed gene variants involved in iron absorption and transport, in the transmembrane protease, serine 6 (TMPRSS6) and transferrin (TF) genes; multiple genetic variants in CUBN, which encodes cubilin (a receptor involved in the absorption of vitamin B12 as well as the reabsorption of transferrin-bound iron and vitamin D in the kidneys); SLC25A37 (involved in iron transport into mitochondria) and CD163 (a scavenger receptor involved in hemorrhage resolution).	Iron	317-321	cubilin	Homo sapiens	206-213
8566699-3	1995	A high molecular mass subunit (83,500 Da) is proposed to contain a molybdenum cofactor, a 27,000 Da subunit is found to be similar to the Fe-S subunit of the formate dehydrogenase from Escherichia coli and a low molecular mass subunit (14,000 Da) holds a c-type heme.	Iron	138-142	DVUA0098	Desulfovibrio vulgaris str. Hildenborough	166-179
30963028-12	2019	Conclusion: Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis.	Iron	153-157	solute carrier family 25 member 37	Homo sapiens	325-333
30884885-9	2019	Whereas MT-1G was also induced by zinc and nickel ions and MT-1H by iron, both MT-1A and MT-1M were highly cadmium-specific, which was confirmed for protein using isoform-specific antibodies.	Iron	68-72	metallothionein 1H	Homo sapiens	59-64
7578019-0	1995	The nature of the thermal equilibrium affecting the iron coordination of ferric cytochrome c.	Iron	52-56	cytochrome c, somatic	Equus caballus	80-92
30932666-0	2019	Evidence for Spin-Triplet Electron Pairing in the Proximity-Induced Superconducting State of an Fe-Doped InAs Semiconductor.	Iron	96-98	spindlin 1	Homo sapiens	13-17
30932666-1	2019	We provide evidence for spin-triplet electron pairing in proximity-induced superconductivity in a ferromagnetic semiconductor (In,Fe)As.	Iron	130-132	spindlin 1	Homo sapiens	24-28
7578019-1	1995	In cytochrome c, ligation of the heme iron by the methionine-80 sulfur plays a major role in determining the structure and the thermodynamic stability of the protein.	Iron	38-42	cytochrome c, somatic	Equus caballus	3-15
30866815-11	2019	CONCLUSIONS: These results indicated that TpSnRK2.10 and TpSnRK2.11 are involved in the uptakes and the translocations of Cd and Fe, possibly by regulating the expression of AtNRAMP1 and AtHMA4, and other genes involved in the synthesis of phytochelatins or hemicellolosic polysaccharides.	Iron	129-131	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	174-182
8748652-2	1995	Frequency- and temperature-dependent T(-1)1 studies of lithium borate and thioborate glasses revealed that iron impurities cause frequency-independent relaxation and "shoulders" of the low-temperature slopes in high fields, whereas manganese produces enhanced relaxation peaks.	Iron	107-111	CD2 molecule	Homo sapiens	37-43
31016283-1	2019	Background: Iron-sulfur cluster assembly 1 (ISCA1) is an iron-sulfur (Fe/S) carrier protein that accepts Fe/S from a scaffold protein and transfers it to target proteins including the mitochondrial Fe/S containing proteins.	Iron	57-61	iron-sulfur cluster assembly 1	Rattus norvegicus	12-42
31016283-1	2019	Background: Iron-sulfur cluster assembly 1 (ISCA1) is an iron-sulfur (Fe/S) carrier protein that accepts Fe/S from a scaffold protein and transfers it to target proteins including the mitochondrial Fe/S containing proteins.	Iron	57-61	iron-sulfur cluster assembly 1	Rattus norvegicus	44-49
31016283-1	2019	Background: Iron-sulfur cluster assembly 1 (ISCA1) is an iron-sulfur (Fe/S) carrier protein that accepts Fe/S from a scaffold protein and transfers it to target proteins including the mitochondrial Fe/S containing proteins.	Iron	70-72	iron-sulfur cluster assembly 1	Rattus norvegicus	12-42
8653076-0	1995	The reducing ability of iron chelates by NADH-cytochrome B5 reductase or cytochrome B5 responsible for NADH-supported lipid peroxidation.	Iron	24-28	cytochrome b5 type A	Homo sapiens	46-59
31016283-1	2019	Background: Iron-sulfur cluster assembly 1 (ISCA1) is an iron-sulfur (Fe/S) carrier protein that accepts Fe/S from a scaffold protein and transfers it to target proteins including the mitochondrial Fe/S containing proteins.	Iron	70-72	iron-sulfur cluster assembly 1	Rattus norvegicus	44-49
30622135-5	2019	Here, we report that human calprotectin (CP; S100A8/S100A9 or MRP8/MRP14 heterooligomer) inhibits iron uptake and induces an iron starvation response in Pseudomonas aeruginosa cells by sequestering Fe(II) at its unusual His6 site.	Iron	98-102	S100 calcium binding protein A9	Homo sapiens	52-58
8653076-0	1995	The reducing ability of iron chelates by NADH-cytochrome B5 reductase or cytochrome B5 responsible for NADH-supported lipid peroxidation.	Iron	24-28	cytochrome b5 type A	Homo sapiens	73-86
30622135-5	2019	Here, we report that human calprotectin (CP; S100A8/S100A9 or MRP8/MRP14 heterooligomer) inhibits iron uptake and induces an iron starvation response in Pseudomonas aeruginosa cells by sequestering Fe(II) at its unusual His6 site.	Iron	98-102	S100 calcium binding protein A9	Homo sapiens	67-72
8653076-2	1995	The results showed the selectivity of NADH-cytochrome b5 reductase or cytochrome b5 towards iron chelates and the subsequent ability of this system to promote peroxidation.	Iron	92-96	cytochrome b5 type A	Homo sapiens	43-56
8653076-2	1995	The results showed the selectivity of NADH-cytochrome b5 reductase or cytochrome b5 towards iron chelates and the subsequent ability of this system to promote peroxidation.	Iron	92-96	cytochrome b5 type A	Homo sapiens	70-83
7556058-5	1995	Treatment of the cells with either phosphatidylinositol-phospholipase C or monoclonal antibodies against p97 resulted in over a 50% reduction and a 47% increase in the iron uptake respectively.	Iron	168-172	melanotransferrin	Homo sapiens	105-108
30589442-6	2019	Body mass index (BMI) and biomarkers of metabolic syndrome, inflammation, and iron stores were used in logistic regression with abnormality in serum GGT, alanine aminotransferase (ALT), or aspartate aminotransferase (AST) as outcomes.	Iron	78-82	gamma-glutamyltransferase 1	Homo sapiens	149-152
7556058-6	1995	These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals.	Iron	63-67	melanotransferrin	Homo sapiens	20-23
7556058-6	1995	These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals.	Iron	134-138	melanotransferrin	Homo sapiens	20-23
30623722-8	2019	In systemic iron overload, elevated urinary iron and transferrin levels were associated with increased injury to proximal tubules, indicated by increased urinary kidney injury marker 1 (KIM-1) excretion.	Iron	12-16	hepatitis A virus cellular receptor 1	Homo sapiens	186-191
30623722-8	2019	In systemic iron overload, elevated urinary iron and transferrin levels were associated with increased injury to proximal tubules, indicated by increased urinary kidney injury marker 1 (KIM-1) excretion.	Iron	44-48	hepatitis A virus cellular receptor 1	Homo sapiens	186-191
7600656-3	1995	The present study examines the effects of copper and iron on the ability of monocytic cells to synthesize and express tissue factor, the potent procoagulant factor.	Iron	53-57	coagulation factor III, tissue factor	Homo sapiens	118-131
30956100-1	2019	Methemoglobin is formed when the iron center in hemoglobin is oxidized from ferrous iron to ferric iron.	Iron	33-37	hemoglobin subunit gamma 2	Homo sapiens	0-13
7598744-2	1995	Subsequent administration of one of the hydroxypyridones CP20, CP24 and CP94, or the siderophore desferrioxamine caused a significant decrease in the iron content of these various brain regions.	Iron	150-154	beaded filament structural protein 1	Rattus norvegicus	72-76
30956100-1	2019	Methemoglobin is formed when the iron center in hemoglobin is oxidized from ferrous iron to ferric iron.	Iron	76-88	hemoglobin subunit gamma 2	Homo sapiens	0-13
30260393-6	2019	SAT expression of the ferritin light chain (FTL) gene, encoding ferritin (FT), an intracellular iron storage protein, was negatively correlated to SREBF1, a gene related to lipogenesis.	Iron	96-100	ferritin light chain	Homo sapiens	22-42
30260393-6	2019	SAT expression of the ferritin light chain (FTL) gene, encoding ferritin (FT), an intracellular iron storage protein, was negatively correlated to SREBF1, a gene related to lipogenesis.	Iron	96-100	ferritin light chain	Homo sapiens	44-47
30742036-2	2019	Vacuolar iron transporter 1 (VIT1) is important for iron homeostasis in plants, by transporting cytoplasmic ferrous ions into vacuoles.	Iron	9-13	LOW QUALITY PROTEIN: vacuolar iron transporter 1-like	Eucalyptus grandis	29-33
30742036-3	2019	Modification of the VIT1 gene leads to increased iron content in crops, which could be used for the treatment of human iron deficiency diseases.	Iron	49-53	LOW QUALITY PROTEIN: vacuolar iron transporter 1-like	Eucalyptus grandis	20-24
7478312-0	1995	The iron-copper connection: the link to ceruloplasmin grows stronger.	Iron	4-8	ceruloplasmin	Homo sapiens	40-53
30787468-2	2019	The following sentence has been inserted following the sentence ending "Aspergillus phytase" in the third paragraph of the article: "Overexpression of AtIRT1, AtNAS1 and bean FERRITIN in rice resulted in 3.8-fold higher iron and 1.8-fold higher zinc concentrations than in the wild-type control12."	Iron	220-224	iron-regulated transporter 1	Arabidopsis thaliana	151-157
7478312-1	1995	A rare genetic defect in ceruloplasmin biosynthesis has provided the strongest evidence to date that ceruloplasmin is essential for iron metabolism and tissue distribution in humans.	Iron	132-136	ceruloplasmin	Homo sapiens	25-38
7478312-1	1995	A rare genetic defect in ceruloplasmin biosynthesis has provided the strongest evidence to date that ceruloplasmin is essential for iron metabolism and tissue distribution in humans.	Iron	132-136	ceruloplasmin	Homo sapiens	101-114
7900806-9	1995	The hepatic iron concentration was increased by eightfold in the iron-loaded rats, and lipocytes from these animals expressed alpha-smooth muscle actin.	Iron	65-69	actin gamma 2, smooth muscle	Rattus norvegicus	126-151
30715865-2	2019	This Communication describes, employing SnO x as a model system, how to moderate coverage of hydroxyl to derive a stable Sn branches catalyst for CO2ER with a 93.1% Faradaic efficiency (FE) of carbonaceous products.	Iron	186-188	strawberry notch homolog 2	Homo sapiens	40-43
30521948-0	2019	The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.	Iron	19-23	RoBo-1	Rattus norvegicus	47-75
30521948-0	2019	The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.	Iron	19-23	C-X-C motif chemokine receptor 3	Rattus norvegicus	121-126
30521948-0	2019	The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.	Iron	96-100	RoBo-1	Rattus norvegicus	47-75
30521948-0	2019	The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.	Iron	96-100	C-X-C motif chemokine receptor 3	Rattus norvegicus	121-126
7900806-12	1995	Chronic iron overload expression results in the activation of lipocytes, as determined by increased expression of alpha-smooth muscle actin and by increased production of both collagen and noncollagen protein.	Iron	8-12	actin gamma 2, smooth muscle	Rattus norvegicus	114-139
30521948-2	2019	Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases.	Iron	0-4	RoBo-1	Rattus norvegicus	26-54
30521948-11	2019	Moreover, iron chelator attenuated neuropathic pain and inhibited the over-expression of CXCL10 and CXCR3 in a dose dependent manner.	Iron	10-14	C-X-C motif chemokine receptor 3	Rattus norvegicus	100-105
30521948-13	2019	Exogenous CXCL10 elicited behavioral hypernociceptive state and CXCR3 over-expression in naive rats, which was reversed by the co-administration of iron chelator.	Iron	148-152	C-X-C motif chemokine receptor 3	Rattus norvegicus	64-69
7887902-6	1995	A fraction of brain MAP2 isolated by iron-chelation affinity chromatography appears to be phosphorylated in vivo at the site recognized by antibody 972.	Iron	37-41	microtubule-associated protein 2	Rattus norvegicus	20-24
30556289-1	2019	The syn and anti isomers of [FeIV (O)(TMC)]2+ (TMC=tetramethylcyclam) represent the first isolated pair of synthetic non-heme oxoiron(IV) complexes with identical ligand topology, differing only in the position of the oxo unit bound to the iron center.	Iron	129-133	synemin	Homo sapiens	4-7
30587002-2	2019	Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum iron levels and traps iron within macrophages.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	46-54
30587002-2	2019	Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum iron levels and traps iron within macrophages.	Iron	125-129	hepcidin antimicrobial peptide	Mus musculus	46-54
30587002-2	2019	Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum iron levels and traps iron within macrophages.	Iron	125-129	hepcidin antimicrobial peptide	Mus musculus	46-54
30587002-2	2019	Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum iron levels and traps iron within macrophages.	Iron	125-129	hepcidin antimicrobial peptide	Mus musculus	46-54
30587002-8	2019	Hamp+/+/ Ldlr-/- mice were treated with iron dextran so as to produce a 2-fold increase in serum iron.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	0-4
7867079-0	1995	Iron differentially modulates the CD4-lck and CD8-lck complexes in resting peripheral blood T-lymphocytes.	Iron	0-4	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
30587002-10	2019	Aortic macrophages from Hamp-/-/ Ldlr-/- mice had less labile free iron and exhibited a reduced proinflammatory (M1) phenotype compared with macrophages from Hamp+/+/ Ldlr-/- mice.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	24-28
30587002-10	2019	Aortic macrophages from Hamp-/-/ Ldlr-/- mice had less labile free iron and exhibited a reduced proinflammatory (M1) phenotype compared with macrophages from Hamp+/+/ Ldlr-/- mice.	Iron	67-71	low density lipoprotein receptor	Mus musculus	33-37
30587002-13	2019	Conclusions- In summary, in a hyperlipidemic mouse model, hepcidin deficiency was associated with decreased macrophage iron, a reduced aortic macrophage inflammatory phenotype and protection from atherosclerosis.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	58-66
30587002-14	2019	The results indicate that decreasing hepcidin activity, with the resulting decrease in macrophage iron, may prove to be a novel strategy for the treatment of atherosclerosis.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	37-45
7867079-2	1995	We have examined the effect of iron in the form of ferric citrate on the CD4-lck and CD8-lck complexes in view of the key role played by the tyrosine kinase p56lck in regulating T-cell functions.	Iron	31-35	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
30612358-5	2019	HgCl2 treatment resulted in oxidation of ferrous iron of hemoglobin to ferric form giving methemoglobin which is inactive as an oxygen transporter.	Iron	49-53	hemoglobin subunit gamma 2	Homo sapiens	90-103
7867079-2	1995	We have examined the effect of iron in the form of ferric citrate on the CD4-lck and CD8-lck complexes in view of the key role played by the tyrosine kinase p56lck in regulating T-cell functions.	Iron	31-35	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-92
30693516-0	2019	Iron overload threatens the growth of osteoblast cells via inhibiting the PI3K/AKT/FOXO3a/DUSP14 signaling pathway.	Iron	0-4	forkhead box O3	Mus musculus	83-89
30693516-0	2019	Iron overload threatens the growth of osteoblast cells via inhibiting the PI3K/AKT/FOXO3a/DUSP14 signaling pathway.	Iron	0-4	dual specificity phosphatase 14	Mus musculus	90-96
7860655-4	1995	Perls" reaction with 3,3"-diaminobenzidine intensification revealed iron deposits in the CA1 region after week 4, which gradually increased and formed clusters by week 24.	Iron	68-72	carbonic anhydrase 1	Rattus norvegicus	89-92
30693516-7	2019	Moreover, iron overload strongly suppressed the expression of dual-specificity phosphatase 14 (DUSP14).	Iron	10-14	dual specificity phosphatase 14	Mus musculus	62-93
30693516-7	2019	Moreover, iron overload strongly suppressed the expression of dual-specificity phosphatase 14 (DUSP14).	Iron	10-14	dual specificity phosphatase 14	Mus musculus	95-101
30693516-8	2019	Additionally, overexpression of DUSP14 protected osteoblast cells from the deleterious effects of iron overload, and this protective effect was mediated by FOXO3a.	Iron	98-102	dual specificity phosphatase 14	Mus musculus	32-38
30693516-8	2019	Additionally, overexpression of DUSP14 protected osteoblast cells from the deleterious effects of iron overload, and this protective effect was mediated by FOXO3a.	Iron	98-102	forkhead box O3	Mus musculus	156-162
30693516-10	2019	Most importantly, our analysis demonstrated the essential role of the PI3K/AKT/FOXO3a/DUSP14 signaling pathway in the defense against iron overload in osteoblast cells.	Iron	134-138	forkhead box O3	Mus musculus	79-85
30693516-10	2019	Most importantly, our analysis demonstrated the essential role of the PI3K/AKT/FOXO3a/DUSP14 signaling pathway in the defense against iron overload in osteoblast cells.	Iron	134-138	dual specificity phosphatase 14	Mus musculus	86-92
7860655-5	1995	Iron also deposited in layers III-V of the parietal cortex after week 8 and gradually built up as granular deposits in the cytoplasm of pyramidal cells in frontocortical layer V. An increasing astroglial reaction and the appearance of ferritin-immunopositive microglia paralleled the iron accumulation in the hippocampal CA1 region, indicating that iron deposition was probably produced in the process of gliosis.	Iron	0-4	carbonic anhydrase 1	Rattus norvegicus	321-324
7878679-3	1995	269, 992-1000, 1994), during the present studies we examined the effect of iron-induced lipid peroxidation on the expression of GST 8-8 in rat liver.	Iron	75-79	glutathione S-transferase alpha 4	Rattus norvegicus	128-135
8589067-5	1995	This enzyme was found to utilize the fastest and simplest way to reduce the heme iron, with the FMN moiety of BMR shuttling between the semiquinone and oxidized states.	Iron	81-85	formin 1	Homo sapiens	96-99
30014470-4	2019	The beneficial cardiovascular biomarkers caveolin-1 and adiponectin were higher in both control and anemic rats fed fermented goat milk either with normal Fe or Fe overload with respect to fermented cow milk.	Iron	161-163	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	56-67
31012640-4	2019	This new artificial material can generate a large spin-orbit torque to switch an adjacent Fe layer.	Iron	90-92	spindlin 1	Homo sapiens	50-54
7945375-3	1994	The present investigation examined whether Adriamycin also reacts with myoglobin, an abundant source of iron in cardiac muscle.	Iron	104-108	myoglobin	Homo sapiens	71-80
7839567-0	1994	Effect of iron status on endotoxin-induced mortality, phagocytosis and interleukin-1 alpha and tumor necrosis factor-alpha production.	Iron	10-14	interleukin 1 alpha	Mus musculus	71-90
30634547-0	2019	Determinants and Sources of Iron Intakes of Australian Toddlers: Findings from the SMILE Cohort Study.	Iron	28-32	transmembrane O-mannosyltransferase targeting cadherins 3	Homo sapiens	83-88
7812636-2	1994	The mechanisms of action on smooth muscle of the iron-sulphur cluster nitrosyl compound, heptanitrosyl-tri-mu 3-thioxotetraferrate (1-), (RBS), a photosensitive nitric oxide donor, have been investigated in the guinea-pig taenia caeci (coli) in vitro.	Iron	49-53	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	138-141
30626086-5	2019	Consequently, PN3 inhibited arachidonic acid (AA) + iron-induced reactive oxygen species generation and glutathione depletion, and, thus, highlighted their role in cytotoxicity.	Iron	52-56	sodium voltage-gated channel alpha subunit 10	Homo sapiens	14-17
30626086-6	2019	Treatment with major polyphenols of PN3, including catechin, chlorogenic acid, caffeic acid, and p-coumaric acid, also improved AA + iron-mediated oxidative stress and, thus, improved cell viability.	Iron	133-137	sodium voltage-gated channel alpha subunit 10	Homo sapiens	36-39
7990851-3	1994	Iron and ferritin levels in the CSF were significantly higher than in a control group of patients.	Iron	0-4	colony stimulating factor 2	Homo sapiens	32-35
30626086-7	2019	Treatment with phenylhydrazine in mice, i.e., the iron overload liver injury model, increased plasma alanine aminotransferase and aspartate aminotransferase levels and changed histological features in mice-a response that was almost completely blocked by PN3 administration.	Iron	50-54	sodium voltage-gated channel alpha subunit 10	Homo sapiens	255-258
30626086-9	2019	Conclusively, PN3 can exert a hepatoprotective effect against iron overload-induced acute liver damage due to its antioxidant properties.	Iron	62-66	sodium voltage-gated channel alpha subunit 10	Homo sapiens	14-17
7990851-4	1994	Six month"s treatment with the iron-chelating agent trientine dihydrochloride led to clinical improvement, with a concomitant reduction of CSF iron level.	Iron	31-35	colony stimulating factor 2	Homo sapiens	139-142
30608934-6	2019	To adequately fit the ferrokinetic data required inclusion of the following mechanisms: a) transferrin-mediated iron delivery to tissues, b) induction of hepcidin by transferrin-bound iron, c) ferroportin-dependent iron export regulated by hepcidin, d) erythropoietin regulation of erythropoiesis, and e) liver uptake of NTBI.	Iron	112-116	transferrin	Mus musculus	91-102
7990851-4	1994	Six month"s treatment with the iron-chelating agent trientine dihydrochloride led to clinical improvement, with a concomitant reduction of CSF iron level.	Iron	143-147	colony stimulating factor 2	Homo sapiens	139-142
30608934-6	2019	To adequately fit the ferrokinetic data required inclusion of the following mechanisms: a) transferrin-mediated iron delivery to tissues, b) induction of hepcidin by transferrin-bound iron, c) ferroportin-dependent iron export regulated by hepcidin, d) erythropoietin regulation of erythropoiesis, and e) liver uptake of NTBI.	Iron	184-188	hepcidin antimicrobial peptide	Mus musculus	154-162
7990851-5	1994	We suggest that, in addition to magnetic resonance imaging findings, CSF levels of iron and ferritin should be used as diagnostic criteria for SH, as well as to estimate the efficacy of iron chelation treatment.	Iron	83-87	colony stimulating factor 2	Homo sapiens	69-72
30608934-6	2019	To adequately fit the ferrokinetic data required inclusion of the following mechanisms: a) transferrin-mediated iron delivery to tissues, b) induction of hepcidin by transferrin-bound iron, c) ferroportin-dependent iron export regulated by hepcidin, d) erythropoietin regulation of erythropoiesis, and e) liver uptake of NTBI.	Iron	184-188	transferrin	Mus musculus	166-177
30608934-6	2019	To adequately fit the ferrokinetic data required inclusion of the following mechanisms: a) transferrin-mediated iron delivery to tissues, b) induction of hepcidin by transferrin-bound iron, c) ferroportin-dependent iron export regulated by hepcidin, d) erythropoietin regulation of erythropoiesis, and e) liver uptake of NTBI.	Iron	184-188	hepcidin antimicrobial peptide	Mus musculus	154-162
30608934-6	2019	To adequately fit the ferrokinetic data required inclusion of the following mechanisms: a) transferrin-mediated iron delivery to tissues, b) induction of hepcidin by transferrin-bound iron, c) ferroportin-dependent iron export regulated by hepcidin, d) erythropoietin regulation of erythropoiesis, and e) liver uptake of NTBI.	Iron	184-188	transferrin	Mus musculus	166-177
12232304-0	1994	Iron Inefficiency in Maize Mutant ys1 (Zea mays L. cv Yellow-Stripe) Is Caused by a Defect in Uptake of Iron Phytosiderophores.	Iron	0-4	iron-phytosiderophore transporter yellow stripe 1	Zea mays	34-37
30347227-1	2019	Mitoferrin genes as members of SLC25 family are conservatively existed across species, mainly locate on mitochondria and serve an important role in the regulation of whole cellular iron metabolism.	Iron	181-185	solute carrier family 25 member 37	Homo sapiens	0-10
30347227-3	2019	In this study, a unique mollusc mitoferrin gene was identified in ark clams, named SbmiFn, that showed conserved three-dimensional structure with other mitoferrins, and its iron binding activity was verified by iron chelating assay.	Iron	173-177	solute carrier family 25 member 37	Homo sapiens	32-42
30347227-3	2019	In this study, a unique mollusc mitoferrin gene was identified in ark clams, named SbmiFn, that showed conserved three-dimensional structure with other mitoferrins, and its iron binding activity was verified by iron chelating assay.	Iron	211-215	solute carrier family 25 member 37	Homo sapiens	32-42
30347227-7	2019	These results refreshed our knowledge on the sequence, structure and functional characteristics of mitoferrin subfamily, and would contribute to further comparative studies on iron metabolism.	Iron	176-180	solute carrier family 25 member 37	Homo sapiens	99-109
12232304-4	1994	Uptake experiments with 59Fe-labeled DMA, purified from root exudates of either Fe-deficient Alice or ys1 plants, showed up to 20 times lower uptake and translocation of 59Fe in ys1 than in Alice or WF9 plants.	Iron	26-28	iron-phytosiderophore transporter yellow stripe 1	Zea mays	102-105
12232304-4	1994	Uptake experiments with 59Fe-labeled DMA, purified from root exudates of either Fe-deficient Alice or ys1 plants, showed up to 20 times lower uptake and translocation of 59Fe in ys1 than in Alice or WF9 plants.	Iron	26-28	iron-phytosiderophore transporter yellow stripe 1	Zea mays	178-181
29666474-2	2019	The human iron-sulfur binding protein NAF-1/CISD2 binds to Bcl-2 and its disruption in cells leads to an increase in apoptosis.	Iron	10-14	CDGSH iron sulfur domain 2	Homo sapiens	44-49
12232304-6	1994	We conclude that Fe inefficiency in the maize mutant ys1 is the result of a defect in the uptake system for Fe-phytosiderophores.	Iron	17-19	iron-phytosiderophore transporter yellow stripe 1	Zea mays	53-56
12232304-6	1994	We conclude that Fe inefficiency in the maize mutant ys1 is the result of a defect in the uptake system for Fe-phytosiderophores.	Iron	108-110	iron-phytosiderophore transporter yellow stripe 1	Zea mays	53-56
8051491-9	1994	The iron-oxidizing antioxidant properties of plasma were mainly dependent on the protein ceruloplasmin, concentrations of which were significantly higher in ARDS patients (0.387 +/- 0.04 gm/L) than in healthy controls (0.265 +/- 0.03 gm/L, p = &lt; 0.05) or patients at risk of ARDS (0.24 +/- 0.04 gm/L, p = &lt; 0.05).	Iron	4-8	ceruloplasmin	Homo sapiens	89-102
30991414-11	2019	Thus, in CKD, decreased expression of TfR1 in erythroblasts as well as increased hepcidin levels in circulation may hamper erythroblast differentiation by decreasing the iron supply, as iron is an indispensable component of erythroblast differentiation.	Iron	170-174	hepcidin antimicrobial peptide	Mus musculus	81-89
30991414-11	2019	Thus, in CKD, decreased expression of TfR1 in erythroblasts as well as increased hepcidin levels in circulation may hamper erythroblast differentiation by decreasing the iron supply, as iron is an indispensable component of erythroblast differentiation.	Iron	186-190	hepcidin antimicrobial peptide	Mus musculus	81-89
30387806-2	2019	The hepcidin-ferroportin axis is the key signaling mechanism that controls systemic iron homeostasis.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	4-12
8066833-4	1994	In particular interleukin-1 and tumor necrosis factor alpha, released from activated macrophages, have been shown to inhibit erythropoiesis and might initiate changes in iron metabolism.	Iron	170-174	interleukin 1 alpha	Homo sapiens	14-59
30460875-4	2019	Furthermore, metal complexation studies on the NMCs and phenols showed that Fe (III) forms a complex with isopropoxyphenol (IPP) within which the Fe:IPP ratio is 1:3, indicative of the formation of a metal chelate complex with the formula Fe(IPP)3.	Iron	76-78	protein phosphatase 1 regulatory inhibitor subunit 11	Homo sapiens	239-247
8164662-5	1994	FRE2 expression, like FRE1 expression, is induced by iron deprivation, and at least part of this control takes place at the transcriptional level, since 156 nucleotides upstream of the initiator AUG conferred iron-dependent regulation when fused to a heterologous gene.	Iron	53-57	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-4
30311259-7	2019	We observed a significant reduction in mRNA levels of heme oxygenase 1 and mitochondrial iron genes like mitoferrin 1 and 2 in monocytes isolated from restless legs syndrome patients, indicating mitochondrial iron deficiency.	Iron	89-93	solute carrier family 25 member 37	Homo sapiens	105-123
8164662-5	1994	FRE2 expression, like FRE1 expression, is induced by iron deprivation, and at least part of this control takes place at the transcriptional level, since 156 nucleotides upstream of the initiator AUG conferred iron-dependent regulation when fused to a heterologous gene.	Iron	209-213	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-4
8075594-0	1994	Most free-radical injury is iron-related: it is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin.	Iron	28-32	ferritin heavy chain 1	Homo sapiens	136-147
30886999-1	2019	Transferrin receptor 2 (Tfr2) is mainly expressed in the liver and controls iron homeostasis.	Iron	76-80	transferrin receptor 2	Mus musculus	0-22
30886999-1	2019	Transferrin receptor 2 (Tfr2) is mainly expressed in the liver and controls iron homeostasis.	Iron	76-80	transferrin receptor 2	Mus musculus	24-28
8131214-2	1994	In the present work, iron (FeC6H5O7) and zinc (ZnCl2) were tested in comparison to nickel (NiCl2) and cobalt (CoCl2) for their effect on six different surface molecules known to be involved in recognition and activation processes, namely CD4, CD2, CD3, CD8, HLA-ABC, and HLA-DR. Iron was seen to down-modulate expression of the CD4 and the CD2 molecules on the surface of T-lymphocytes, as indicated by a decrease in the mean fluorescence intensity measured by FACS analysis.	Iron	21-25	CD2 molecule	Homo sapiens	243-246
30420567-3	2019	Here, we dissected genetic relationships among these three key components and found that (1) STOP1, ALMT1, and LPR1 act downstream of ALS3/STAR1 in controlling PR growth under Pi deficiency; (2) ALS3/STAR1 inhibits the STOP1-ALMT1 pathway by repressing STOP1 protein accumulation in the nucleus; and (3) STOP1-ALMT1 and LPR1 control PR growth under Pi deficiency in an interdependent manner involving the promotion of malate-dependent Fe accumulation in roots.	Iron	435-437	Cupredoxin superfamily protein	Arabidopsis thaliana	111-115
30420567-3	2019	Here, we dissected genetic relationships among these three key components and found that (1) STOP1, ALMT1, and LPR1 act downstream of ALS3/STAR1 in controlling PR growth under Pi deficiency; (2) ALS3/STAR1 inhibits the STOP1-ALMT1 pathway by repressing STOP1 protein accumulation in the nucleus; and (3) STOP1-ALMT1 and LPR1 control PR growth under Pi deficiency in an interdependent manner involving the promotion of malate-dependent Fe accumulation in roots.	Iron	435-437	non-intrinsic ABC protein 3	Arabidopsis thaliana	139-144
30420567-3	2019	Here, we dissected genetic relationships among these three key components and found that (1) STOP1, ALMT1, and LPR1 act downstream of ALS3/STAR1 in controlling PR growth under Pi deficiency; (2) ALS3/STAR1 inhibits the STOP1-ALMT1 pathway by repressing STOP1 protein accumulation in the nucleus; and (3) STOP1-ALMT1 and LPR1 control PR growth under Pi deficiency in an interdependent manner involving the promotion of malate-dependent Fe accumulation in roots.	Iron	435-437	non-intrinsic ABC protein 3	Arabidopsis thaliana	200-205
30312900-6	2019	Its position is in close proximity and mutually exclusive to the ribosomal binding site of release/recycling factor ABCE1, which harbors a redox-sensitive Fe-S cluster and, like diphthamide, is present in eukaryotes and archaea but not in eubacteria.	Iron	155-159	ATP binding cassette subfamily E member 1	Homo sapiens	116-121
8131214-2	1994	In the present work, iron (FeC6H5O7) and zinc (ZnCl2) were tested in comparison to nickel (NiCl2) and cobalt (CoCl2) for their effect on six different surface molecules known to be involved in recognition and activation processes, namely CD4, CD2, CD3, CD8, HLA-ABC, and HLA-DR. Iron was seen to down-modulate expression of the CD4 and the CD2 molecules on the surface of T-lymphocytes, as indicated by a decrease in the mean fluorescence intensity measured by FACS analysis.	Iron	21-25	CD2 molecule	Homo sapiens	340-343
30265966-1	2018	We develop for the first time a new electrochemical biosensor for signal-on detection of T4 polynucleotide kinase (PNK) based on the enhanced quasi-reversible redox signal of prussian blue generated by self-sacrificial label of iron metal-organic framework (FeMOF).	Iron	228-238	polynucleotide kinase 3'-phosphatase	Homo sapiens	115-118
30544799-0	2018	Iron Supplements Containing Lactobacillus plantarum 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures.	Iron	0-4	cytochrome b reductase 1	Homo sapiens	115-120
30544799-9	2018	In conclusion, the data suggest that the effect of L. plantarum 299v on iron metabolism is mediated through driving the Fe3+/DCYTB axis.	Iron	72-76	cytochrome b reductase 1	Homo sapiens	125-130
30403845-5	2018	In contrast, the mean Fe-N distances and  Fe-N-Fe angles correlate linearly with the [Fe6] oxidation level, or alternatively, the changes observed within the local Fe-N4 coordination planes vary linearly with the aggregate spin ground state.	Iron	22-24	spindlin 1	Homo sapiens	223-227
30372872-6	2018	Plasma non-transferrin bound iron (NTBI), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepcidin and insulin; tissue iron and MDA were measured.	Iron	29-33	transferrin	Mus musculus	11-22
30172039-16	2018	Moreover, dysregulation of iron homeostasis may be due to MC-LR-induced Hamp1 downregulation, possibly mediated by hypoxia or the IL6-STAT3 and BMP-SMAD signaling pathways.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	72-77
30172043-5	2018	FeNAgTiO2 composite beads were characterized through SEM/EDS, XRD and DRS to confirm the presence of Fe along with Ag, N and TiO2 on the surface of beads.	Iron	0-2	Drosomycin	Drosophila melanogaster	70-73
30218772-10	2018	Liver tumors were observed in MUTYH-null mice after 12 months  high iron diet, but no tumors developed when dietary anti-oxidant (N-Acetyl-L-cysteine) was also provided.	Iron	68-72	mutY DNA glycosylase	Mus musculus	30-35
30218772-12	2018	MUTYH-null mice with iron-associated oxidative stress were susceptible to development of liver tumors unless prevented by dietary anti-oxidants.	Iron	21-25	mutY DNA glycosylase	Mus musculus	0-5
30076709-1	2018	Nuclear receptor coactivator 4 mediated ferritinophagy is an autophagic phenomenon that specifically involves ferritin to release intracellular free iron.	Iron	149-153	nuclear receptor coactivator 4	Homo sapiens	0-30
30218980-1	2018	Iron deficiency is routinely treated with oral or systemic iron supplements, which are highly reactive and could induce oxidative stress via augmenting the activity of proinflammatory enzyme myeloperoxidase (MPO).	Iron	59-63	myeloperoxidase	Mus musculus	191-206
30218980-1	2018	Iron deficiency is routinely treated with oral or systemic iron supplements, which are highly reactive and could induce oxidative stress via augmenting the activity of proinflammatory enzyme myeloperoxidase (MPO).	Iron	59-63	myeloperoxidase	Mus musculus	208-211
30218980-4	2018	Systemic iron administration up-regulated circulating MPO and neutrophil elastase and elevated systemic inflammatory and organ damage markers in WT mice.	Iron	9-13	myeloperoxidase	Mus musculus	54-57
30218980-5	2018	However, genetic deletion of MPO or its inhibition significantly reduced iron-induced organ damage and systemic inflammatory responses.	Iron	73-77	myeloperoxidase	Mus musculus	29-32
30218980-9	2018	Altogether, genetic deficiency or pharmacologic inhibition of MPO substantially attenuated acute and chronic iron-induced toxicity.	Iron	109-113	myeloperoxidase	Mus musculus	62-65
30218980-10	2018	Our results suggest that targeting MPO during iron supplementation is a promising approach to reduce iron-induced toxicity/side effects in vulnerable population.	Iron	46-50	myeloperoxidase	Mus musculus	35-38
30218980-10	2018	Our results suggest that targeting MPO during iron supplementation is a promising approach to reduce iron-induced toxicity/side effects in vulnerable population.	Iron	101-105	myeloperoxidase	Mus musculus	35-38
8145237-11	1994	The results are consistent with the hypothesis that CYP1A1 produces NAPQI preferentially because of closer proximity of the heme iron to the amide nitrogen, whereas CYP2B1 produces 3-OH-APAP preferentially because of closer proximity of the heme iron to the phenolic oxygen in this isoform.	Iron	129-133	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	52-58
8145237-11	1994	The results are consistent with the hypothesis that CYP1A1 produces NAPQI preferentially because of closer proximity of the heme iron to the amide nitrogen, whereas CYP2B1 produces 3-OH-APAP preferentially because of closer proximity of the heme iron to the phenolic oxygen in this isoform.	Iron	246-250	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	52-58
8114094-2	1994	In wild-type yeast iso-1-cytochrome c the position and orientation of this water molecule is found to be dependent on the oxidation state of the heme iron atom.	Iron	150-154	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	19-24
8182785-0	1994	Effects of oral iron therapy on serum copper and serum ceruloplasmin in children.	Iron	16-20	ceruloplasmin	Homo sapiens	55-68
8293472-3	1994	CTR1 mutants and deletion strains have profound deficiency in ferrous iron uptake, thus revealing a requirement for copper in mediating ferrous transport into the cell.	Iron	62-74	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	0-4
7762428-1	1994	Lactoferrin from milk may have a physiological effect on the neonate by stimulating iron acquisition and/or mucosal growth.	Iron	84-88	lactotransferrin	Bos taurus	0-11
7762428-6	1994	Competitive binding experiments showed that holo-lactoferrin was more effective than less Fe-saturated forms of lactoferrin with regard to receptor binding.	Iron	90-92	lactotransferrin	Bos taurus	112-123
7762431-12	1994	These mutations involve the iron binding ligands and have been designed to introduce some of the changes found in the C-lobe of melanotransferrin into LfN.	Iron	28-32	melanotransferrin	Homo sapiens	128-145
7762432-1	1994	Lactoferrin was found to contain an antimicrobial sequence near its N-terminus which appears to function by a mechanism distinct from iron chelation.	Iron	134-138	lactotransferrin	Bos taurus	0-11
7762434-5	1994	Lf was hydrolyzed by heat treatment at pH 2 to 3 at above 100 degrees C, and its iron binding capacity and antigenicity were lost.	Iron	81-85	lactotransferrin	Bos taurus	0-2
7762443-2	1994	To investigate the mechanism of action of the iron-binding protein, lactoferrin (Lf), on cultured animal cells, the effect of bovine Lf (bLf) on NGF synthesis/secretion in mouse fibroblast cells was examined.	Iron	46-50	lactotransferrin	Bos taurus	68-79
7762443-2	1994	To investigate the mechanism of action of the iron-binding protein, lactoferrin (Lf), on cultured animal cells, the effect of bovine Lf (bLf) on NGF synthesis/secretion in mouse fibroblast cells was examined.	Iron	46-50	lactotransferrin	Bos taurus	81-83
8299120-3	1994	Removal of macrophages/monocytes from rat splenocytes by plastic or nylon-wool adherence, or iron ingestion resulted in LAK induction by IL-2 in the absence of 2-mercaptoethanol.	Iron	93-97	interleukin 2	Rattus norvegicus	137-141
8115547-5	1994	In chimeric mRNA, soybean ferritin mRNA sequences blocked the function of the iron regulatory element (IRE), the cis regulatory element of animal ferritin mRNA; the IRE regulates chimeric animal mRNAs.	Iron	78-82	ferritin-1, chloroplastic	Glycine max	26-34
8115547-5	1994	In chimeric mRNA, soybean ferritin mRNA sequences blocked the function of the iron regulatory element (IRE), the cis regulatory element of animal ferritin mRNA; the IRE regulates chimeric animal mRNAs.	Iron	78-82	ferritin-1, chloroplastic	Glycine max	146-154
8115547-9	1994	An autocatalytic mechanism observed in vivo for degradation of plastid protein D1 and in vitro for pea ferritin during iron release could explain the ferritin decreases in mature nodules.	Iron	119-123	ferritin-1, chloroplastic	Glycine max	103-111
8115547-9	1994	An autocatalytic mechanism observed in vivo for degradation of plastid protein D1 and in vitro for pea ferritin during iron release could explain the ferritin decreases in mature nodules.	Iron	119-123	ferritin-1, chloroplastic	Glycine max	150-158
8298023-1	1993	The causes of the strong coupling of the iron-histidine vibration to the Soret resonance in the resonance Raman spectra of deoxyhemoglobin, myoglobin, and peroxidase are explored, using the vibronic theory.	Iron	41-45	myoglobin	Homo sapiens	140-149
30510543-3	2018	To evaluate the impact of the feed intake level on the feed efficiency (FE)-associated variation in the chicken intestinal microbiota, differently feed efficient chickens need to eat the same amount of feed, which can be achieved by feeding chickens restrictively.	Iron	72-74	FI	Gallus gallus	30-41
30340826-0	2018	Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/beta-catenin pathway in colon cancer cells.	Iron	0-4	N-myc downstream regulated 1	Homo sapiens	39-44
8345124-4	1993	As indicated by use of cibacron blue affinity gel, iron bound to lactoferrin, and the charge of supersaturated lactoferrin was higher than that of normal iron-saturated lactoferrin according to native PAGE electrophoresis.	Iron	154-158	lactotransferrin	Bos taurus	111-122
30381188-3	2018	Two genes were identified whose deletion resulted in sensitivity to EGCG: FET3 and FTR1, encoding the components of the Fet3/Ftr1 high-affinity iron uptake system, also involved in Cu(I)/Cu(II) balance on the surface of yeast cells.	Iron	144-148	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	83-87
30381188-3	2018	Two genes were identified whose deletion resulted in sensitivity to EGCG: FET3 and FTR1, encoding the components of the Fet3/Ftr1 high-affinity iron uptake system, also involved in Cu(I)/Cu(II) balance on the surface of yeast cells.	Iron	144-148	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	125-129
8345124-4	1993	As indicated by use of cibacron blue affinity gel, iron bound to lactoferrin, and the charge of supersaturated lactoferrin was higher than that of normal iron-saturated lactoferrin according to native PAGE electrophoresis.	Iron	154-158	lactotransferrin	Bos taurus	111-122
8345124-5	1993	The evidence suggests that lactoferrin can bind iron at sites other than its chelate-binding sites, thereby stabilizing iron in solution.	Iron	48-52	lactotransferrin	Bos taurus	27-38
8345124-5	1993	The evidence suggests that lactoferrin can bind iron at sites other than its chelate-binding sites, thereby stabilizing iron in solution.	Iron	120-124	lactotransferrin	Bos taurus	27-38
8516331-1	1993	The picosecond evolution of the tertiary conformation of myoglobin (Mb) after photodissociation of MbCO was investigated at room temperature by probing band III, a weak iron-porphyrin charge-transfer transition near 13,110 cm-1 (763 nm) that is sensitive to the out-of-plane displacement of the iron.	Iron	169-173	myoglobin	Homo sapiens	57-66
30350980-7	2018	Taken together, long-term high-fat diet decreases hepatic iron storage, which is closely linked to inhibition of liver iron transport through the TFR2 and ZIP14-dependent pathway.	Iron	58-62	transferrin receptor 2	Rattus norvegicus	146-150
30350980-7	2018	Taken together, long-term high-fat diet decreases hepatic iron storage, which is closely linked to inhibition of liver iron transport through the TFR2 and ZIP14-dependent pathway.	Iron	119-123	transferrin receptor 2	Rattus norvegicus	146-150
30383537-0	2018	Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1alpha/beta and Presenilin 1 expression via PGE2 and PGD2 at the early stage of Alzheimer"s Disease.	Iron	56-60	transferrin	Mus musculus	0-11
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	33-37	transferrin	Mus musculus	0-11
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	87-91	transferrin	Mus musculus	0-11
8516331-1	1993	The picosecond evolution of the tertiary conformation of myoglobin (Mb) after photodissociation of MbCO was investigated at room temperature by probing band III, a weak iron-porphyrin charge-transfer transition near 13,110 cm-1 (763 nm) that is sensitive to the out-of-plane displacement of the iron.	Iron	169-173	myoglobin	Homo sapiens	68-70
30383537-1	2018	Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD).	Iron	97-99	transferrin	Mus musculus	0-11
8516331-1	1993	The picosecond evolution of the tertiary conformation of myoglobin (Mb) after photodissociation of MbCO was investigated at room temperature by probing band III, a weak iron-porphyrin charge-transfer transition near 13,110 cm-1 (763 nm) that is sensitive to the out-of-plane displacement of the iron.	Iron	295-299	myoglobin	Homo sapiens	57-66
8516331-1	1993	The picosecond evolution of the tertiary conformation of myoglobin (Mb) after photodissociation of MbCO was investigated at room temperature by probing band III, a weak iron-porphyrin charge-transfer transition near 13,110 cm-1 (763 nm) that is sensitive to the out-of-plane displacement of the iron.	Iron	295-299	myoglobin	Homo sapiens	68-70
30218014-6	2018	New findings on the crosstalk between iron and Pi homeostasis in the regulation of FGF23 expression will also be outlined.	Iron	38-42	fibroblast growth factor 23	Homo sapiens	83-88
8500909-0	1993	Iron acquisition by Helicobacter pylori: importance of human lactoferrin.	Iron	0-4	lactotransferrin	Bos taurus	61-72
30388772-0	2018	The Fast Cooking and Enhanced Iron Bioavailability Properties of the Manteca Yellow Bean (Phaseolus vulgaris L.).	Iron	30-34	brain expressed associated with NEDD4 1	Homo sapiens	84-88
8500909-5	1993	Human lactoferrin supported full growth of the bacteria in media lacking other iron sources, but neither human transferrin, bovine lactoferrin, nor hen ovotransferrin served as a source for iron.	Iron	79-83	lactotransferrin	Bos taurus	6-17
8500909-6	1993	Since lactoferrin was found in significant amounts in human stomach resections with superficial or atrophic gastritis, the iron acquisition system of H. pylori by the human lactoferrin receptor system may play a major role in the virulence of H. pylori infection.	Iron	123-127	lactotransferrin	Bos taurus	6-17
8500909-6	1993	Since lactoferrin was found in significant amounts in human stomach resections with superficial or atrophic gastritis, the iron acquisition system of H. pylori by the human lactoferrin receptor system may play a major role in the virulence of H. pylori infection.	Iron	123-127	lactotransferrin	Bos taurus	173-184
30213871-1	2018	Systemic iron balance is controlled by hepcidin, a liver hormone that limits iron efflux to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	39-47
30213871-1	2018	Systemic iron balance is controlled by hepcidin, a liver hormone that limits iron efflux to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	39-47
8338887-7	1993	The affinity of the monoclonal antibody for the ferritin deprived of iron (apoferritin) was higher than that for native ferritin due to the greater conformational flexibility of the apoferritin molecule.	Iron	69-73	ferritin heavy chain 1	Homo sapiens	75-86
30213871-1	2018	Systemic iron balance is controlled by hepcidin, a liver hormone that limits iron efflux to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	39-47
30213871-2	2018	Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	15-23
30213871-2	2018	Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload.	Iron	0-4	hemojuvelin BMP co-receptor	Mus musculus	43-54
30213871-2	2018	Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload.	Iron	0-4	hemojuvelin BMP co-receptor	Mus musculus	56-59
30213871-2	2018	Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload.	Iron	203-207	hepcidin antimicrobial peptide	Mus musculus	15-23
8338887-7	1993	The affinity of the monoclonal antibody for the ferritin deprived of iron (apoferritin) was higher than that for native ferritin due to the greater conformational flexibility of the apoferritin molecule.	Iron	69-73	ferritin heavy chain 1	Homo sapiens	182-193
30213871-2	2018	Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload.	Iron	203-207	hemojuvelin BMP co-receptor	Mus musculus	43-54
30213871-2	2018	Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload.	Iron	203-207	hemojuvelin BMP co-receptor	Mus musculus	56-59
8478396-7	1993	Basic fibroblast growth factor (bFGF), nerve growth factor (NGF), and insulin-like growth factors (IGF-I and IGF-II) each protected neurons against iron-induced damage.	Iron	148-152	insulin-like growth factor 1	Rattus norvegicus	99-104
8385134-3	1993	In contrast, recombinant enzyme expressed in Sf9 cells using a baculovirus vector was active and identical in several properties to phenylalanine hydroxylase from rat liver: the Km for 6-methyltetrahydropterin was 39 microM (compared with 35 microM for the rat liver enzyme), 1 atom of iron was "associated" per enzyme subunit, and electron paramagnetic resonance spectra showed that iron was distributed within two distinct environments.	Iron	286-290	phenylalanine hydroxylase	Rattus norvegicus	132-157
30252434-5	2018	Among various internal microstructures, the obtained double-shelled copper-zinc-iron MSHMs exhibited the superior catalytic performance toward 8.8 and 38 mumol for H2 and CO productions as well as 80.4% removal of sulfamethoxazole antibiotics.	Iron	80-84	relaxin 2	Homo sapiens	164-173
30360520-1	2018	Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin ("ferritinophagy"), the cytosolic iron storage complex.	Iron	156-160	nuclear receptor coactivator 4	Homo sapiens	0-30
30360520-1	2018	Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin ("ferritinophagy"), the cytosolic iron storage complex.	Iron	156-160	nuclear receptor coactivator 4	Homo sapiens	32-37
30360520-2	2018	NCOA4-mediated ferritinophagy maintains intracellular iron homeostasis by facilitating ferritin iron storage or release according to demand.	Iron	54-58	nuclear receptor coactivator 4	Homo sapiens	0-5
30360520-2	2018	NCOA4-mediated ferritinophagy maintains intracellular iron homeostasis by facilitating ferritin iron storage or release according to demand.	Iron	96-100	nuclear receptor coactivator 4	Homo sapiens	0-5
8385134-3	1993	In contrast, recombinant enzyme expressed in Sf9 cells using a baculovirus vector was active and identical in several properties to phenylalanine hydroxylase from rat liver: the Km for 6-methyltetrahydropterin was 39 microM (compared with 35 microM for the rat liver enzyme), 1 atom of iron was "associated" per enzyme subunit, and electron paramagnetic resonance spectra showed that iron was distributed within two distinct environments.	Iron	384-388	phenylalanine hydroxylase	Rattus norvegicus	132-157
30360520-3	2018	Ferritinophagy is involved in iron-dependent physiological processes such as erythropoiesis, where NCOA4 mediates ferritin iron release for mitochondrial heme synthesis.	Iron	123-127	nuclear receptor coactivator 4	Homo sapiens	99-104
8385134-4	1993	Putative iron-binding sites of phenylalanine hydroxylase were studied by mutating either histidine 284 or 289 to serine and expressing these mutant enzymes (PAH-H284S and PAH-H289S) in Sf9 cells.	Iron	9-13	phenylalanine hydroxylase	Rattus norvegicus	31-56
8385134-4	1993	Putative iron-binding sites of phenylalanine hydroxylase were studied by mutating either histidine 284 or 289 to serine and expressing these mutant enzymes (PAH-H284S and PAH-H289S) in Sf9 cells.	Iron	9-13	phenylalanine hydroxylase	Rattus norvegicus	157-160
8385134-4	1993	Putative iron-binding sites of phenylalanine hydroxylase were studied by mutating either histidine 284 or 289 to serine and expressing these mutant enzymes (PAH-H284S and PAH-H289S) in Sf9 cells.	Iron	9-13	phenylalanine hydroxylase	Rattus norvegicus	171-174
30321179-2	2018	Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney epithelial cells, so that hardly any iron is found in the urine.	Iron	68-72	transferrin	Mus musculus	50-61
30321179-2	2018	Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney epithelial cells, so that hardly any iron is found in the urine.	Iron	172-176	transferrin	Mus musculus	50-61
30321179-4	2018	Transferrin Receptor 1 was decreased as expected, following iron overload.	Iron	60-64	transferrin	Mus musculus	0-11
30321179-9	2018	This suggests that despite the reduction of Transferrin Receptor 1, alternative pathways may effectively mediate re-absorption of iron that cycles through the kidney during parenterally induced iron-overload.	Iron	130-134	transferrin	Mus musculus	44-55
8314900-5	1993	Kinetic studies in melanoma cells have suggested that p97 plays a role in iron metabolism.	Iron	74-78	melanotransferrin	Homo sapiens	54-57
30027360-8	2018	In addition, significantly up-regulated expression of FtH and FtL mRNA, and markedly down-regulated expression of Tfr1, Dmt1 + IRE and Ireg1 mRNA, were observed in the iron overload group compared with the control group.	Iron	168-172	RoBo-1	Rattus norvegicus	120-124
8314900-10	1993	These observations provide a basis for the elucidation of the physiological role of p97 in iron metabolism and its possible role in cell proliferation and malignant cell transformation.	Iron	91-95	melanotransferrin	Homo sapiens	84-87
8449958-3	1993	The previous identification of iron-responsive elements in the 5"-untranslated region of human and murine erythroid ALAS mRNA raised the intriguing possibility that eALAS expression might be under iron-dependent translational control.	Iron	197-201	aminolevulinic acid synthase 1	Mus musculus	116-120
29903760-0	2018	Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.	Iron	12-16	hepcidin antimicrobial peptide	Mus musculus	52-60
29903760-1	2018	The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric transferrin.	Iron	66-70	transferrin	Mus musculus	153-164
8395932-4	1993	The coadministration of DED with BGD or PBGD significantly prevented the increase in the lipid peroxidation, hemoglobin, Ca and Fe in the testes, the decrease in the testicular weight and NP-SH, and the sterility caused by Cd injection.	Iron	128-130	hydroxymethylbilane synthase	Rattus norvegicus	40-44
30073618-7	2018	Expression analysis of these transporters supports the conclusion that Slc9a2 and Slc40a1 within the mammary gland could mediate the effect of Mmcq9 on milk Fe concentration.	Iron	157-159	solute carrier family 9 (sodium/hydrogen exchanger), member 2	Mus musculus	71-77
30171894-8	2018	We found that Kir6.2 knockout suppressed the excessive iron accumulation in MPTP-treated mouse midbrain and inhibited the upregulation of ferritin light chain (FTL), which is a main intracellular iron storage protein.	Iron	196-200	ferritin light polypeptide 1	Mus musculus	138-158
30171894-8	2018	We found that Kir6.2 knockout suppressed the excessive iron accumulation in MPTP-treated mouse midbrain and inhibited the upregulation of ferritin light chain (FTL), which is a main intracellular iron storage protein.	Iron	196-200	ferritin light polypeptide 1	Mus musculus	160-163
8428002-9	1993	rEPO-treated normal subjects (but not the rEPO-treated patient with hemochromatosis or untreated controls) produced iron-deficient RBCs with elevated zinc protoporphyrin levels and low hemoglobin content.	Iron	116-120	erythropoietin	Rattus norvegicus	0-4
30241424-0	2018	Sucrosomial  Iron Supplementation in Mice: Effects on Blood Parameters, Hepcidin, and Inflammation.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	72-80
30137082-6	2018	In response to iron deficiency, the yeast Aft1 transcription factor activates cellular iron acquisition.	Iron	15-19	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	42-46
8423097-2	1993	Recent work has indicated that in addition to binding iron, human lactoferrin damages the outer membrane of gram-negative bacteria.	Iron	54-58	lactotransferrin	Bos taurus	66-77
30137082-7	2018	However, when constitutively active, Aft1 inhibits growth probably due to iron toxicity.	Iron	74-78	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	37-41
30137082-8	2018	In this report, we have studied the consequences of using hyperactive AFT1 alleles, including AFT1-1UP, to increase yeast iron accumulation.	Iron	122-126	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	70-74
30137082-8	2018	In this report, we have studied the consequences of using hyperactive AFT1 alleles, including AFT1-1UP, to increase yeast iron accumulation.	Iron	122-126	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	94-98
30137082-9	2018	We first characterized the iron sensitivity of cells expressing different constitutively active AFT1 alleles.	Iron	27-31	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	96-100
30137082-10	2018	We rescued the high iron sensitivity conferred by the AFT1 alleles by deleting the sphingolipid signaling kinase YPK1.	Iron	20-24	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	54-58
8099003-1	1993	The in vitro exposure of human lymphocytes to degradation products (Fe, Ni or Co) of metallic biomaterials causes a significant reduction of lymphocytes expressing the molecules involved in T lymphocyte activation, CD2 and CD3.	Iron	68-70	CD2 molecule	Homo sapiens	215-218
30137082-11	2018	We observed that the deletion of YPK1 exerts different effects on iron accumulation depending on the AFT1 allele and the environmental iron.	Iron	66-70	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	101-105
30137082-12	2018	Moreover, we determined that the impairment of the high-affinity iron transport system partially rescues the high iron toxicity of AFT1-1UP-expressing cells.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	131-135
30137082-12	2018	Moreover, we determined that the impairment of the high-affinity iron transport system partially rescues the high iron toxicity of AFT1-1UP-expressing cells.	Iron	114-118	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	131-135
29878645-2	2018	An environmentally benign and cost effective synthesis method of Cr alloyed Nd2 (Fe,Co)14 B magnetic nanoparticles using a dry mechanochemical process is reported.	Iron	81-83	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	76-79
8375432-5	1993	A ferroxidase, ceruloplasmin, significantly inhibited the lipid peroxidation induced by the dopa-Fe3+ complex, indicating the importance of the reduction of iron moiety in the complex for the lipid peroxidation.	Iron	157-161	ceruloplasmin	Homo sapiens	15-28
29878645-6	2018	The HC of isolated Nd2 (Fe11.25 Co2 Cr0.75 )B nanoparticles and nanoparticles embedded in a CaO matrix is found to be 11.5 kOe and 14.4 kOe, respectively, largest values for heavy rare earth free Nd-Fe-B nanoparticles with reasonable saturation and remanent magnetization, regardless of synthesis route.	Iron	24-26	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	19-22
30277616-5	2018	Our findings indicate that iron impaction to corneal tissue results in cleavage of 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 variant (PLCB2; 134 kDa) into a 36 kDa species and presence of the epithelial layer is necessary for this cleavage.	Iron	27-31	phospholipase C beta 2	Homo sapiens	157-162
30277616-10	2018	Iron impaction of corneal tissue for 24 hours results in cleavage of PLCB2 commensurate with significant changes in phosphatidylinositols but not phosphatidylcholines or other phospholipids.	Iron	0-4	phospholipase C beta 2	Homo sapiens	69-74
29298491-3	2018	In diabetes, impaired Hp 2-2-Hb CD163 clearance and abnormal glomerular permeability allow the large Hp 2-2-Hb complex to cross the barrier, where its redox active iron leads to cellular toxicity.	Iron	164-168	CD163 molecule	Homo sapiens	32-37
1453445-2	1992	1H nuclear magnetic resonance studies of Dolabella met-cyano myoglobin have revealed that a guanidino NH proton of Arg-E10 is hydrogen-bonded to the Fe-bound CN-.	Iron	149-151	myoglobin	Homo sapiens	61-70
30250850-0	2018	The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice.	Iron	4-8	klotho	Homo sapiens	9-15
30250850-0	2018	The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice.	Iron	4-8	vitamin D receptor	Homo sapiens	16-19
30250850-5	2018	In this study, we set out to test the hypothesis that the increased renal iron deposits in the PCT of Hp 2-2 DN affect the alpha-klotho-vitamin D receptor (VDR) axis and thereby exacerbates the PCT injury generated by the iron deposits.	Iron	74-78	vitamin D receptor	Homo sapiens	123-154
30250850-5	2018	In this study, we set out to test the hypothesis that the increased renal iron deposits in the PCT of Hp 2-2 DN affect the alpha-klotho-vitamin D receptor (VDR) axis and thereby exacerbates the PCT injury generated by the iron deposits.	Iron	74-78	vitamin D receptor	Homo sapiens	156-159
30250850-5	2018	In this study, we set out to test the hypothesis that the increased renal iron deposits in the PCT of Hp 2-2 DN affect the alpha-klotho-vitamin D receptor (VDR) axis and thereby exacerbates the PCT injury generated by the iron deposits.	Iron	222-226	vitamin D receptor	Homo sapiens	156-159
1453445-3	1992	The role of Arg-E10 as a hydrogen-bond donor for Fe-bound ligand in the present myoglobin appears to be responsible for its relatively high ligand affinity.	Iron	49-51	myoglobin	Homo sapiens	80-89
30250850-6	2018	Immunohistochemical analysis of human and mouse kidney biopsies along with western blot analysis showed that the increased iron deposits in the PCT of the Hp 2-2 genotype were accompanied with significantly decreased alpha-klotho and VDR renal expression but significantly increased 1-alpha-hydroxylase renal expression.	Iron	123-127	klotho	Mus musculus	223-229
1327127-4	1992	From the increase of the rate of electron transfer with decreasing pH, one of the driving forces of the reaction was suggested to be the difference in the redox potentials between the type 1 copper in laccase and the central iron in cytochrome c.	Iron	225-229	cytochrome c, somatic	Equus caballus	233-245
30250850-6	2018	Immunohistochemical analysis of human and mouse kidney biopsies along with western blot analysis showed that the increased iron deposits in the PCT of the Hp 2-2 genotype were accompanied with significantly decreased alpha-klotho and VDR renal expression but significantly increased 1-alpha-hydroxylase renal expression.	Iron	123-127	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	234-237
30250850-7	2018	In conclusion, the iron-klotho-VDR axis is a major player in the mechanism contributing to iron-mediated PCT injury in diabetic Hp 2-2 mice and patients.	Iron	19-23	klotho	Mus musculus	24-30
30250850-7	2018	In conclusion, the iron-klotho-VDR axis is a major player in the mechanism contributing to iron-mediated PCT injury in diabetic Hp 2-2 mice and patients.	Iron	19-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	31-34
30250850-7	2018	In conclusion, the iron-klotho-VDR axis is a major player in the mechanism contributing to iron-mediated PCT injury in diabetic Hp 2-2 mice and patients.	Iron	91-95	klotho	Mus musculus	24-30
30250850-7	2018	In conclusion, the iron-klotho-VDR axis is a major player in the mechanism contributing to iron-mediated PCT injury in diabetic Hp 2-2 mice and patients.	Iron	91-95	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	31-34
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	36-40	ankyrin repeat domain 37	Homo sapiens	174-198
1536576-2	1992	It was shown that loading of apoferritin with ferrous ammonium sulfate was dependent on buffer and pH, and was directly related to the rate of iron autoxidation.	Iron	143-147	ferritin heavy chain 1	Homo sapiens	29-40
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	36-40	ankyrin repeat domain 37	Homo sapiens	201-208
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	70-74	ankyrin repeat domain 37	Homo sapiens	174-198
29110513-9	2018	The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter ( Dmt1), transferrin receptor ( TfR), ankyrin repeat domain 37 ( Ankrd37), and hepcidin ( Hamp) in IDA-induced Caco-2 and HepG2 cells.	Iron	70-74	ankyrin repeat domain 37	Homo sapiens	201-208
1536576-7	1992	We suggest that the loading of apoferritin with ferrous ammonium sulfate occurred as a result of iron autoxidation and may result in oxidation of amino acids and loss of integrity of the protein, and that ceruloplasmin may act as a catalyst for the incorporation of iron into apoferritin in a manner more closely related to that occurring in vivo.	Iron	97-101	ferritin heavy chain 1	Homo sapiens	31-42
1536576-7	1992	We suggest that the loading of apoferritin with ferrous ammonium sulfate occurred as a result of iron autoxidation and may result in oxidation of amino acids and loss of integrity of the protein, and that ceruloplasmin may act as a catalyst for the incorporation of iron into apoferritin in a manner more closely related to that occurring in vivo.	Iron	266-270	ferritin heavy chain 1	Homo sapiens	31-42
29244196-9	2018	Additionally, iron overload induced G1arrest in MC3T3-E1 cells and down-regulated the expression of Cyclin D1 , Cyclin D3 , CDK2, CDK4 and CDK6, but up-regulated p27 Kip1.	Iron	14-18	cyclin D1	Mus musculus	100-109
1536576-7	1992	We suggest that the loading of apoferritin with ferrous ammonium sulfate occurred as a result of iron autoxidation and may result in oxidation of amino acids and loss of integrity of the protein, and that ceruloplasmin may act as a catalyst for the incorporation of iron into apoferritin in a manner more closely related to that occurring in vivo.	Iron	266-270	ceruloplasmin	Homo sapiens	205-218
29244196-9	2018	Additionally, iron overload induced G1arrest in MC3T3-E1 cells and down-regulated the expression of Cyclin D1 , Cyclin D3 , CDK2, CDK4 and CDK6, but up-regulated p27 Kip1.	Iron	14-18	cyclin-dependent kinase 2	Mus musculus	124-128
29244196-9	2018	Additionally, iron overload induced G1arrest in MC3T3-E1 cells and down-regulated the expression of Cyclin D1 , Cyclin D3 , CDK2, CDK4 and CDK6, but up-regulated p27 Kip1.	Iron	14-18	cyclin-dependent kinase inhibitor 1B	Mus musculus	162-170
1309791-6	1992	First, direct electron transfer to heme iron in ferrylmyoglobin (HX-FeIV=O) with formation of met-myoglobin (HX-FeIII) or oxymyoglobin (HX-FeIIO2); the former transition was effected by all thiols except dihydrolipoate, which facilitated the latter, i.e. the formation of the two-electron reduction product of ferrylmyoglobin.	Iron	40-44	myoglobin	Homo sapiens	54-63
29677776-2	2018	The oxygen content of the Fe powders heat-treated in Ar and Ar-H2 atmosphere was much lower than that of the Fe powder heat-treated in air atmosphere.	Iron	26-28	ADP-ribosylhydrolase like 1	Homo sapiens	60-65
29165637-1	2018	Background: Intravenous (IV) iron can modulate fibroblast growth factor 23 (FGF23) concentrations and cause transient but significant hypophosphataemia.	Iron	29-33	fibroblast growth factor 23	Homo sapiens	47-74
1309791-8	1992	The contribution of either direct electron transfer to the heme iron or nucleophilic addition depended on the physicochemical properties of the thiol involved and on the availability of H2O2 to reoxidize met-myoglobin to ferrylmyoglobin.	Iron	64-68	myoglobin	Homo sapiens	208-217
29165637-1	2018	Background: Intravenous (IV) iron can modulate fibroblast growth factor 23 (FGF23) concentrations and cause transient but significant hypophosphataemia.	Iron	29-33	fibroblast growth factor 23	Homo sapiens	76-81
1791188-5	1991	Electrophoretically separated holo-rat transferrin and rat lung-derived growth factor displayed similar positive stains for iron.	Iron	124-128	myotrophin	Rattus norvegicus	72-85
30093529-7	2018	These studies describe how point mutations of the transferrin receptor can cause a microcytic anemia that does not respond to iron therapy and would not be detected by routine iron studies, such as serum ferritin.	Iron	126-130	transferrin	Mus musculus	50-61
30093529-7	2018	These studies describe how point mutations of the transferrin receptor can cause a microcytic anemia that does not respond to iron therapy and would not be detected by routine iron studies, such as serum ferritin.	Iron	176-180	transferrin	Mus musculus	50-61
1742921-5	1991	Iron absorption in EPO-treated rats was 4.8 +/- 2.0% (n = 12) and 4.5 +/- 2.2% (n = 10) in the control rats (p greater than 0.05).	Iron	0-4	erythropoietin	Rattus norvegicus	19-22
29752985-6	2018	Our results indicate that a 0.25% carbonyl iron diet is sufficient to induce maximal hepatic hepcidin response.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	93-101
1742921-7	1991	Mean hepatic iron concentration was 73 +/- 16 mumol/g in the control rats and 34 +/- 9.1 mumol/g in the EPO-treated rats (p less than 0.001).	Iron	13-17	erythropoietin	Rattus norvegicus	104-107
1718317-4	1991	In particular, there is a complete sequence identity for the iron-responsive element (IRE) located in the 5"-untranslated region in both XL2-17 and Rana catesbeiana ferritin mRNAs.	Iron	61-65	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	137-143
29624734-4	2018	We found that iron accumulation in MPSIIIB mice primarily affected the cerebral cortex where hepcidin levels were higher than in wild-type mice, and increased with aging.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	93-101
29624734-8	2018	Hepcidin induction results from activation of the TLR4 pathway and STAT3 signaling, and leads to iron retention within microglia.	Iron	97-101	hepcidin antimicrobial peptide	Mus musculus	0-8
1718317-4	1991	In particular, there is a complete sequence identity for the iron-responsive element (IRE) located in the 5"-untranslated region in both XL2-17 and Rana catesbeiana ferritin mRNAs.	Iron	61-65	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	165-173
1892822-5	1991	Performing X-ray absorption fine structure experiments on both solution and crystalline met-myoglobin (met-Mb), we find significant differences in the local environment of the iron between the two states.	Iron	160-164	myoglobin	Homo sapiens	92-101
29853274-2	2018	FA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters.	Iron	130-134	frataxin	Mus musculus	44-47
1896472-0	1991	Ferritin gene transcription is regulated by iron in soybean cell cultures.	Iron	44-48	ferritin-1, chloroplastic	Glycine max	0-8
30111419-11	2018	CONCLUSION: Mice engineered to carry exogenous mutant gene RUNX1-S291fs and injected with iron showed pathologic features of MDS and iron overload, resulting in establishing MDS iron overloaded mouse model successfully, which lays a foundation for studying the effect of iron overload on MDS.	Iron	90-94	runt related transcription factor 1	Mus musculus	59-64
30111419-11	2018	CONCLUSION: Mice engineered to carry exogenous mutant gene RUNX1-S291fs and injected with iron showed pathologic features of MDS and iron overload, resulting in establishing MDS iron overloaded mouse model successfully, which lays a foundation for studying the effect of iron overload on MDS.	Iron	133-137	runt related transcription factor 1	Mus musculus	59-64
30111419-11	2018	CONCLUSION: Mice engineered to carry exogenous mutant gene RUNX1-S291fs and injected with iron showed pathologic features of MDS and iron overload, resulting in establishing MDS iron overloaded mouse model successfully, which lays a foundation for studying the effect of iron overload on MDS.	Iron	133-137	runt related transcription factor 1	Mus musculus	59-64
30111419-11	2018	CONCLUSION: Mice engineered to carry exogenous mutant gene RUNX1-S291fs and injected with iron showed pathologic features of MDS and iron overload, resulting in establishing MDS iron overloaded mouse model successfully, which lays a foundation for studying the effect of iron overload on MDS.	Iron	133-137	runt related transcription factor 1	Mus musculus	59-64
1896472-1	1991	Iron-regulated ferritin synthesis in animals is dominated by translational control of stored mRNA; iron-induced transcription of ferritin genes, when it occurs, changes the subunit composition of ferritin mRNA and protein and is coupled to translational control.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	15-23
30085777-0	2018	Spin-Orbit Coupling and Magnetic Anisotropy in Iron-Based Superconductors.	Iron	47-51	spindlin 1	Homo sapiens	0-4
1896472-1	1991	Iron-regulated ferritin synthesis in animals is dominated by translational control of stored mRNA; iron-induced transcription of ferritin genes, when it occurs, changes the subunit composition of ferritin mRNA and protein and is coupled to translational control.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	129-137
30085777-1	2018	We determine theoretically the effect of spin-orbit coupling on the magnetic excitation spectrum of itinerant multiorbital systems, with specific application to iron-based superconductors.	Iron	161-165	spindlin 1	Homo sapiens	41-45
1896472-1	1991	Iron-regulated ferritin synthesis in animals is dominated by translational control of stored mRNA; iron-induced transcription of ferritin genes, when it occurs, changes the subunit composition of ferritin mRNA and protein and is coupled to translational control.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	129-137
1896472-1	1991	Iron-regulated ferritin synthesis in animals is dominated by translational control of stored mRNA; iron-induced transcription of ferritin genes, when it occurs, changes the subunit composition of ferritin mRNA and protein and is coupled to translational control.	Iron	99-103	ferritin-1, chloroplastic	Glycine max	15-23
1896472-1	1991	Iron-regulated ferritin synthesis in animals is dominated by translational control of stored mRNA; iron-induced transcription of ferritin genes, when it occurs, changes the subunit composition of ferritin mRNA and protein and is coupled to translational control.	Iron	99-103	ferritin-1, chloroplastic	Glycine max	129-137
29874065-3	2018	The deprotonation patterns have been determined by X-ray crystallography and 1H NMR spectroscopy and discussed in relation to the spin state of the iron(II) centers, which influences greatly the p Ka of the ligand.	Iron	148-152	spindlin 1	Homo sapiens	130-134
1896472-1	1991	Iron-regulated ferritin synthesis in animals is dominated by translational control of stored mRNA; iron-induced transcription of ferritin genes, when it occurs, changes the subunit composition of ferritin mRNA and protein and is coupled to translational control.	Iron	99-103	ferritin-1, chloroplastic	Glycine max	129-137
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	28-36
29915044-5	2018	Mice with deletion of Ttp display cardiac dysfunction with iron deficiency, demonstrating that TTP is necessary for maintaining cardiac function in the setting of low cellular iron.	Iron	59-63	zinc finger protein 36	Mus musculus	22-25
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	126-134
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	126-134
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	126-134
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	181-185	ferritin-1, chloroplastic	Glycine max	28-36
29797729-0	2018	Ultrafast Photoinduced Multimode Antiferromagnetic Spin Dynamics in Exchange-Coupled Fe/RFeO3 (R = Er or Dy) Heterostructures.	Iron	85-87	spindlin 1	Homo sapiens	51-55
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	181-185	ferritin-1, chloroplastic	Glycine max	126-134
29797729-2	2018	Here, the photoinduced excitation of ultrafast antiferromagnetic spin dynamics is achieved by capping antiferromagnetic RFeO3 (R = Er or Dy) with an exchange-coupled ferromagnetic Fe film.	Iron	121-123	spindlin 1	Homo sapiens	65-69
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	181-185	ferritin-1, chloroplastic	Glycine max	126-134
1896472-4	1991	Iron-regulated synthesis of ferritin in plants and animals appears to be very different since the 50- to 60-fold increases of ferritin protein, previously observed to be induced by iron in cultured soybean cells, is accompanied by an equivalent accumulation of hybridizable ferritin mRNA and by increased transcription of ferritin genes.	Iron	181-185	ferritin-1, chloroplastic	Glycine max	126-134
1896472-5	1991	Ferritin mRNA from iron-induced cells and the constitutive ferritin mRNA from soybean hypocotyls are identical.	Iron	19-23	ferritin-1, chloroplastic	Glycine max	0-8
1896472-7	1991	Differences in animal ferritin structure coincide with the various iron storage functions (reserve for iron proteins and detoxification).	Iron	67-71	ferritin-1, chloroplastic	Glycine max	22-30
29481308-7	2018	Furthermore, we show that blocking FGF23 signaling attenuates inflammation, resulting in increased serum iron and ferritin levels.	Iron	105-109	fibroblast growth factor 23	Mus musculus	35-40
1896472-7	1991	Differences in animal ferritin structure coincide with the various iron storage functions (reserve for iron proteins and detoxification).	Iron	103-107	ferritin-1, chloroplastic	Glycine max	22-30
1896472-8	1991	In contrast, the constancy of structure of soybean ferritin, iron-induced and constitutive, coupled with the potential for vacuolar storage of excess iron in plants suggest that rapid synthesis of ferritin from a stored ferritin mRNA may not be needed in plants for detoxification of iron.	Iron	61-65	ferritin-1, chloroplastic	Glycine max	197-205
1896472-8	1991	In contrast, the constancy of structure of soybean ferritin, iron-induced and constitutive, coupled with the potential for vacuolar storage of excess iron in plants suggest that rapid synthesis of ferritin from a stored ferritin mRNA may not be needed in plants for detoxification of iron.	Iron	61-65	ferritin-1, chloroplastic	Glycine max	197-205
29457657-5	2018	Here, we demonstrate that, similar to rodents, human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor.	Iron	146-150	hepatitis A virus cellular receptor 1	Homo sapiens	210-215
1896472-8	1991	In contrast, the constancy of structure of soybean ferritin, iron-induced and constitutive, coupled with the potential for vacuolar storage of excess iron in plants suggest that rapid synthesis of ferritin from a stored ferritin mRNA may not be needed in plants for detoxification of iron.	Iron	150-154	ferritin-1, chloroplastic	Glycine max	197-205
1896472-8	1991	In contrast, the constancy of structure of soybean ferritin, iron-induced and constitutive, coupled with the potential for vacuolar storage of excess iron in plants suggest that rapid synthesis of ferritin from a stored ferritin mRNA may not be needed in plants for detoxification of iron.	Iron	150-154	ferritin-1, chloroplastic	Glycine max	197-205
1896472-8	1991	In contrast, the constancy of structure of soybean ferritin, iron-induced and constitutive, coupled with the potential for vacuolar storage of excess iron in plants suggest that rapid synthesis of ferritin from a stored ferritin mRNA may not be needed in plants for detoxification of iron.	Iron	150-154	ferritin-1, chloroplastic	Glycine max	197-205
29377263-3	2018	Hepcidin is a key iron-regulatory hormone, which maintains body iron balance.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
1896472-8	1991	In contrast, the constancy of structure of soybean ferritin, iron-induced and constitutive, coupled with the potential for vacuolar storage of excess iron in plants suggest that rapid synthesis of ferritin from a stored ferritin mRNA may not be needed in plants for detoxification of iron.	Iron	150-154	ferritin-1, chloroplastic	Glycine max	197-205
1893995-2	1991	It is suggested that EDRF is a nitrosyl iron complex with low-molecular thiol ligands, most probably with cysteine.	Iron	40-44	alpha hemoglobin stabilizing protein	Homo sapiens	21-25
29703633-0	2018	Oral Versus Intravenous Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients on Maintenance Hemodialysis-Effect on Fibroblast Growth Factor-23 Metabolism.	Iron	24-28	fibroblast growth factor 23	Homo sapiens	139-166
29703633-1	2018	OBJECTIVE: Iron administration affects serum levels of intact (I-) fibroblast growth factor-23 (FGF23) and its cleavage product C-terminal (C-) FGF23 in iron-deficient patients on maintenance hemodialysis (MHD).	Iron	11-15	fibroblast growth factor 23	Homo sapiens	67-94
29703633-1	2018	OBJECTIVE: Iron administration affects serum levels of intact (I-) fibroblast growth factor-23 (FGF23) and its cleavage product C-terminal (C-) FGF23 in iron-deficient patients on maintenance hemodialysis (MHD).	Iron	11-15	fibroblast growth factor 23	Homo sapiens	96-101
29703633-1	2018	OBJECTIVE: Iron administration affects serum levels of intact (I-) fibroblast growth factor-23 (FGF23) and its cleavage product C-terminal (C-) FGF23 in iron-deficient patients on maintenance hemodialysis (MHD).	Iron	11-15	fibroblast growth factor 23	Homo sapiens	144-149
29703633-2	2018	The objective of this study was to compare the effect of oral or intravenous iron administration on serum levels of I-FGF23 and C-FGF23 in iron-deficient patients on MHD.	Iron	77-81	fibroblast growth factor 23	Homo sapiens	118-123
29703633-2	2018	The objective of this study was to compare the effect of oral or intravenous iron administration on serum levels of I-FGF23 and C-FGF23 in iron-deficient patients on MHD.	Iron	77-81	fibroblast growth factor 23	Homo sapiens	130-135
1712288-1	1991	The chloroplast gene psaC encoding the iron sulfur protein of photosystem I (PSI) from the green alga Chlamydomonas reinhardtii has been cloned and characterized.	Iron	39-43	photosystem I subunit VII	Chlamydomonas reinhardtii	21-25
29703633-11	2018	Multiple regression analysis indicated the relationship between iron or erythropoiesis and FGF23 metabolism.	Iron	64-68	fibroblast growth factor 23	Homo sapiens	91-96
29703633-12	2018	CONCLUSION: Iron administration to patients on MHD with severe iron deficiency decreased C-FGF23 levels, whereas intravenous iron increased I-FGF23 levels though oral iron did not.	Iron	12-16	fibroblast growth factor 23	Homo sapiens	91-96
29703633-12	2018	CONCLUSION: Iron administration to patients on MHD with severe iron deficiency decreased C-FGF23 levels, whereas intravenous iron increased I-FGF23 levels though oral iron did not.	Iron	125-129	fibroblast growth factor 23	Homo sapiens	142-147
29703633-13	2018	If the target of chronic kidney disease-mineral and bone disorder therapy is reducing I-FGF23 levels, we suggest the use of oral iron.	Iron	129-133	fibroblast growth factor 23	Homo sapiens	88-93
1679940-2	1991	The iron-core is gradually built up when FeII is added to apoferritin and allowed to oxidize.	Iron	4-8	ferritin heavy chain 1	Homo sapiens	58-69
29603761-7	2018	RESULTS: Generally, iron chelation achieved via CP94 or AP2-18 administration significantly increased PpIX fluorescence.	Iron	20-24	transcription factor AP-2 alpha	Homo sapiens	56-59
29603761-12	2018	CONCLUSIONS: PpIX fluorescence levels, as well as PDT cell kill effects on irradiation can be significantly increased by pyridinone iron chelation, either via the addition of CP94 to the administration of a PpIX precursor or alternatively via the newly synthesized combined PpIX prodrug and siderophore, AP2-18.	Iron	132-136	transcription factor AP-2 alpha	Homo sapiens	304-310
29735522-6	2018	We further found that the presence of non-transferrin-bound iron (NTBI) in the circulation is more important than total plasma or tissue iron in rendering mice susceptible to infection and mortality.	Iron	60-64	transferrin	Mus musculus	42-53
2049409-6	1991	The monoclonal antibody, 96.5, specific for melanotransferrin did not alter total Fe uptake but slightly increased the proportion of Fe internalised, possibly due to the modulation of the antigen by the antibody.	Iron	133-135	melanotransferrin	Homo sapiens	44-61
29912874-4	2018	By complementary approaches, we demonstrate that Cth2 protein inhibits the translation of SDH4, which encodes a subunit of succinate dehydrogenase, and CTH2 mRNAs in response to iron depletion.	Iron	178-182	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	90-94
29748130-8	2018	Moreover, chronic iron overload led to increased plasma non-transferrin bound iron (NTBI) and cardiac iron deposition, impaired cardiac intracellular Ca2+ transients including decreased intracellular Ca2+ transient amplitude, rising rate and decay rate, as well as impaired LV function as indicated by a decreased %LV ejection fraction (%LVEF) in both WT and HT mice.	Iron	18-22	transferrin	Mus musculus	60-71
1675959-12	1991	The high hepatic uptake of iron from ovotransferrin was probably mediated by the asialoglycoprotein receptors on hepatocytes.	Iron	27-31	transferrin (ovotransferrin)	Gallus gallus	37-51
29847566-3	2018	Here, the functions of the putative TonB-dependent iron transporter of RA-CH-1, B739_1343, in iron utilization and pathogenicity were investigated.	Iron	51-55	B739_RS06605	Riemerella anatipestifer RA-CH-1	80-89
29847566-4	2018	Under iron-starved conditions, the mutant strain RA-CH-1DeltaB739_1343 exhibited more seriously impaired growth than the wild-type strain RA-CH-1, and the expression of B739_1343 in the mutant strain restored growth.	Iron	6-10	B739_RS06605	Riemerella anatipestifer RA-CH-1	61-70
2211706-1	1990	Ferritin is a large multisubunit protein that stores iron in plants, animals, and bacteria.	Iron	53-57	ferritin-1, chloroplastic	Glycine max	0-8
29896216-13	2018	Our results showed that obese subjects have increased expressions of miR-155 and miR-122, two microRNAs that were previously related with inflammation and iron metabolism, respectively, at both the systemic and sperm levels.	Iron	155-159	microRNA 155	Homo sapiens	69-76
29896216-13	2018	Our results showed that obese subjects have increased expressions of miR-155 and miR-122, two microRNAs that were previously related with inflammation and iron metabolism, respectively, at both the systemic and sperm levels.	Iron	155-159	microRNA 122	Homo sapiens	81-88
2083287-0	1990	[The effect of monoamine oxidase type A inhibitors on chemoluminescence of blood serum in the presence of divalent iron ions].	Iron	115-119	monoamine oxidase A	Homo sapiens	15-39
29872401-0	2018	Excessive Iron Availability Caused by Disorders of Interleukin-10 and Interleukin-22 Contributes to High Altitude Polycythemia.	Iron	10-14	interleukin 10	Homo sapiens	51-65
29872401-0	2018	Excessive Iron Availability Caused by Disorders of Interleukin-10 and Interleukin-22 Contributes to High Altitude Polycythemia.	Iron	10-14	interleukin 22	Homo sapiens	70-84
2202145-5	1990	Ceruloplasmin (cuproenzyme) is imperative for iron mobilization from storage sites for hemoglobin synthesis.	Iron	46-50	ceruloplasmin	Homo sapiens	0-13
29769596-0	2018	Hcp/fcc nucleation in bcc iron under different anisotropic compressions at high strain rate: Molecular dynamics study.	Iron	26-30	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	0-3
2166170-12	1990	The conservation of this structural feature and its close proximity to the heme iron atom strongly implicate this internal water molecule as having a functional role in the mechanism of action of cytochrome c.	Iron	80-84	cytochrome c, somatic	Equus caballus	196-208
29523554-6	2018	In mice, LIPA inhibition caused defective clearance of apoptotic lymphocytes and stressed erythrocytes by hepatic and splenic macrophages, culminating in splenomegaly and splenic iron accumulation under hypercholesterolemia.	Iron	179-183	lysosomal acid lipase A	Mus musculus	9-13
29665677-4	2018	Fe-TBP was built from iron-oxo clusters and porphyrin ligands and sensitized PDT under both normoxic and hypoxic conditions.	Iron	22-26	TATA-box binding protein	Homo sapiens	3-6
2379560-1	1990	We have demonstrated that the intracellular processing of transferrin to effect iron removal involves two pathways, one sensitive to rotenone and the other not.	Iron	80-84	inhibitor of carbonic anhydrase	Cavia porcellus	58-69
2379560-2	1990	We have also found that the effect of the rotenone is dependent on the transferrin concentration: iron uptake was suppressed with concentrations of transferrin in the micromolar range, and was not suppressed at physiologic concentrations of transferrin.	Iron	98-102	inhibitor of carbonic anhydrase	Cavia porcellus	71-82
2379560-2	1990	We have also found that the effect of the rotenone is dependent on the transferrin concentration: iron uptake was suppressed with concentrations of transferrin in the micromolar range, and was not suppressed at physiologic concentrations of transferrin.	Iron	98-102	inhibitor of carbonic anhydrase	Cavia porcellus	148-159
2379560-2	1990	We have also found that the effect of the rotenone is dependent on the transferrin concentration: iron uptake was suppressed with concentrations of transferrin in the micromolar range, and was not suppressed at physiologic concentrations of transferrin.	Iron	98-102	inhibitor of carbonic anhydrase	Cavia porcellus	148-159
2379560-7	1990	The second pathway begins with an intracellular site which has a high capacity (but low affinity) for either iron or transferrin and is utilized when transferrin is in physiologic concentration (and the low-capacity, high-affinity site is saturated); the pathway it initiates is dominant when transferrin is abundant.	Iron	109-113	inhibitor of carbonic anhydrase	Cavia porcellus	150-161
2379560-7	1990	The second pathway begins with an intracellular site which has a high capacity (but low affinity) for either iron or transferrin and is utilized when transferrin is in physiologic concentration (and the low-capacity, high-affinity site is saturated); the pathway it initiates is dominant when transferrin is abundant.	Iron	109-113	inhibitor of carbonic anhydrase	Cavia porcellus	150-161
2092051-8	1990	Since it is known that N-ethylmaleimide inhibits the endosomal proton pump, our results strongly suggest that the endocytotic pathway is a necessary route in transferrin mediated transplacental iron transfer.	Iron	194-198	inhibitor of carbonic anhydrase	Cavia porcellus	158-169
2355004-4	1990	It was found that the prosthetic heme was modified by a CCl2 moiety derived from BrCCl3 and was covalently bound to histidine residue 93, the normal proximal ligand to the heme-iron.	Iron	177-181	C-C motif chemokine ligand 2	Homo sapiens	56-60
2364114-1	1990	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	39-56
2364114-1	1990	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	58-61
2364114-10	1990	340,000 per cell (assuming 2 atoms of iron per site) and it is suggested that this binding component may be melanotransferrin.	Iron	38-42	melanotransferrin	Homo sapiens	108-125
2199206-8	1990	Peak inspiratory Pdi, without pressure applied in the iron lung, increased from 13.6 +/- 5.4 to 28.1 +/- 13.5 cmH2O after methacholine; extrathoracic pressure of -20 cmH2O decreased this latter value to 15.4 +/- 7.3 cmH2O (p less than 0.01).	Iron	54-58	peptidyl arginine deiminase 1	Homo sapiens	17-20
2338008-7	1990	The erythrocyte sedimentation rate and plasma iron levels were correlated with the levels of C1q binding immune complexes (IC) in the synovial fluid; total iron binding capacity showed an inverse relationship to synovial fluid IgG-RF levels.	Iron	46-50	complement C1q A chain	Homo sapiens	93-96
2154454-6	1990	When neutrophils, monocytes, or MDM were stimulated with phorbol 12-myristate 13-acetate or opsonized zymosan in the presence of exogenous iron, catalase-inhibitable PBN/.OCH3 was the sole nitroxide detected.	Iron	139-143	secreted LY6/PLAUR domain containing 1	Homo sapiens	32-35
2184175-9	1990	Inhibitory properties of dry cow secretion are partially explained by lactoferrin acting in conjunction with antibody to prevent iron acquisition by many gram-negative bacteria.	Iron	129-133	lactotransferrin	Bos taurus	70-81
2154249-1	1990	Several lines of evidence have recently suggested the occurrence of a specific lactotransferrin receptor in the small intestinal brush-border membrane in several animal species, which is thought to be involved in lactotransferrin-mediated intestinal iron absorption.	Iron	250-254	lactotransferrin	Mus musculus	79-95
2154249-1	1990	Several lines of evidence have recently suggested the occurrence of a specific lactotransferrin receptor in the small intestinal brush-border membrane in several animal species, which is thought to be involved in lactotransferrin-mediated intestinal iron absorption.	Iron	250-254	lactotransferrin	Mus musculus	213-229
2154249-4	1990	The purified receptor was found to be active in that it binds iron-free and iron-saturated lactotransferrin with a Kd of 0.1 microM.	Iron	76-80	lactotransferrin	Mus musculus	91-107
1966784-6	1990	The protective action of CP and p-CP during RBC lysis in two Fe(2+)-containing systems did not correlate with their oxidative and ferroxidase activities.	Iron	61-63	ceruloplasmin	Homo sapiens	25-27
1966784-6	1990	The protective action of CP and p-CP during RBC lysis in two Fe(2+)-containing systems did not correlate with their oxidative and ferroxidase activities.	Iron	61-63	ceruloplasmin	Homo sapiens	34-36
2295476-6	1990	In addition, there was a 28% decrease in mitochondrial aldehyde dehydrogenase in iron-loaded livers but no change in cytosolic aldehyde dehydrogenase.	Iron	81-85	aldehyde dehydrogenase 2 family member	Rattus norvegicus	41-77
2284564-3	1990	The results obtained showed that in iron-deficit anemia resistant to iron therapy the copper and ceruloplasmin serum concentrations are at the lowest limit of normal.	Iron	36-40	ceruloplasmin	Homo sapiens	97-110
33824974-0	2021	Hepatocyte Neogenin Is Required for Hemojuvelin-Mediated Hepcidin Expression and Iron Homeostasis in Mice.	Iron	81-85	neogenin	Mus musculus	11-19
33824974-4	2021	However, the role of NEO1 in iron homeostasis remains controversial because of the lack of an appropriate animal model.	Iron	29-33	neogenin	Mus musculus	21-25
33824974-6	2021	Results show that ablation of hepatocyte Neo1 decreased hepcidin expression and caused iron overload.	Iron	87-91	neogenin	Mus musculus	41-45
33774058-0	2021	Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with NAFLD.	Iron	86-90	ceruloplasmin	Homo sapiens	0-13
33774058-11	2021	CONCLUSIONS: Variants in non-HFE iron genes, particularly Ceruloplasmin, are associated with hyperferritinemia and increased hepatic iron stores in patients with NAFLD.	Iron	33-37	ceruloplasmin	Homo sapiens	58-71
33774058-11	2021	CONCLUSIONS: Variants in non-HFE iron genes, particularly Ceruloplasmin, are associated with hyperferritinemia and increased hepatic iron stores in patients with NAFLD.	Iron	133-137	ceruloplasmin	Homo sapiens	58-71
33774058-15	2021	We found that variants of genes related to iron metabolism, particularly Ceruloplasmin, are associated with high ferritin levels, hepatic iron deposition and more severe liver disease in Italian NAFLD patients.	Iron	43-47	ceruloplasmin	Homo sapiens	73-86
33774058-15	2021	We found that variants of genes related to iron metabolism, particularly Ceruloplasmin, are associated with high ferritin levels, hepatic iron deposition and more severe liver disease in Italian NAFLD patients.	Iron	138-142	ceruloplasmin	Homo sapiens	73-86
33815094-0	2021	Elevated Heme Oxygenase-1 Correlates With Increased Brain Iron Deposition Measured by Quantitative Susceptibility Mapping and Decreased Hemoglobin in Patients With Parkinson"s Disease.	Iron	58-62	heme oxygenase 1	Homo sapiens	9-25
29374603-2	2018	Using an experimental model of brain iron accumulation, we have shown that iron induces severe memory deficits that are accompanied by oxidative stress, increased apoptotic markers, and decreased synaptophysin in the hippocampus of rats.	Iron	75-79	synaptophysin	Rattus norvegicus	196-209
33815094-3	2021	Objective: To explore the association of the level of HO-1 with brain iron deposition and low level of HGB in PD.	Iron	70-74	heme oxygenase 1	Homo sapiens	54-58
33815094-11	2021	There was a significantly positive correlation between the serum HO-1 concentration and iron deposition within SN, an inverse correlation between the serum HO-1 concentration and HGB level in PD patients.	Iron	88-92	heme oxygenase 1	Homo sapiens	65-69
33587911-4	2021	In the future, heme oxygenase-1 (HO-1) may also become a candidate ILD biomarker; it is a 32-kDa heat shock protein converting heme to carbon monoxide, biliverdin/bilirubin, and free iron to play a role in the pulmonary cytoprotective reaction in response to various stimuli.	Iron	183-187	heme oxygenase 1	Homo sapiens	15-31
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	21-25	nuclear receptor coactivator 4	Homo sapiens	131-153
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	21-25	nuclear receptor coactivator 4	Homo sapiens	155-160
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	191-195	nuclear receptor coactivator 4	Homo sapiens	131-153
29461259-6	2018	RECENT FINDINGS: The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells.	Iron	191-195	nuclear receptor coactivator 4	Homo sapiens	155-160
33587911-4	2021	In the future, heme oxygenase-1 (HO-1) may also become a candidate ILD biomarker; it is a 32-kDa heat shock protein converting heme to carbon monoxide, biliverdin/bilirubin, and free iron to play a role in the pulmonary cytoprotective reaction in response to various stimuli.	Iron	183-187	heme oxygenase 1	Homo sapiens	33-37
33233553-11	2020	SIRT3KO significantly exacerbated Ang-II-induced iron accumulation.	Iron	49-53	sirtuin 3	Mus musculus	0-7
29315562-3	2018	The HFE protein is critical for the regulation of cellular iron uptake.	Iron	59-63	homeostatic iron regulator	Mus musculus	4-7
33233553-14	2020	CONCLUSION: Our study suggests that SIRT3 deficiency sensitized Ang-II-induced renal fibrosis by the mechanisms involved in promoting differentiation of pericytes into fibroblasts, exacerbating iron overload and accelerating NADPH oxidase-derived ROS formation.	Iron	194-198	sirtuin 3	Mus musculus	36-41
29136618-8	2017	Increased hepcidin expression results in increased intracellular sequestration of iron, and is associated with the complications of type 2 diabetes.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	10-18
29729700-11	2018	Change in CD16 expression may implicate preliminarily neutrophil activation as a response of iron-overloaded tissue and result in chronic inflammation in beta-thalassemia patients.	Iron	93-97	Fc gamma receptor IIIa	Homo sapiens	10-14
29136618-11	2017	Therefore, measuring hepcidin may improve differential diagnosis and the monitoring of disorders of iron metabolism.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	21-29
29700330-6	2018	Iron overloading, on the other hand, resulted in downregulation of GLUT2 and insulin in a PrPC-dependent manner.	Iron	0-4	solute carrier family 2 member 2	Homo sapiens	67-72
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	42-46	ferritin heavy chain 1	Homo sapiens	149-177
29755643-0	2018	Tumor associated macrophages deliver iron to tumor cells via Lcn2.	Iron	37-41	lipocalin 2	Homo sapiens	61-65
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	42-46	ferritin heavy chain 1	Homo sapiens	179-183
29755643-5	2018	In the present study, we found that iron concentration was significantly increased at tumor metastatic stage, which could be attributed to up-regulated expression of lipocalin2 (Lcn2).	Iron	36-40	lipocalin 2	Homo sapiens	166-176
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	42-46	ferritin heavy chain 1	Homo sapiens	234-238
29755643-5	2018	In the present study, we found that iron concentration was significantly increased at tumor metastatic stage, which could be attributed to up-regulated expression of lipocalin2 (Lcn2).	Iron	36-40	lipocalin 2	Homo sapiens	178-182
29755643-7	2018	Moreover, TAMs increased intracellular iron concentration in tumor cells via Lcn2 as transporter, which could be restored by Lcn2 antibody neutralization.	Iron	39-43	lipocalin 2	Homo sapiens	77-81
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	108-112	ferritin heavy chain 1	Homo sapiens	149-177
29755643-7	2018	Moreover, TAMs increased intracellular iron concentration in tumor cells via Lcn2 as transporter, which could be restored by Lcn2 antibody neutralization.	Iron	39-43	lipocalin 2	Homo sapiens	125-129
29755643-8	2018	In conclusion, TAMs increased intracellular iron concentration of the tumor cells via Lcn2 which acted as an iron transporter.	Iron	44-48	lipocalin 2	Homo sapiens	86-90
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	108-112	ferritin heavy chain 1	Homo sapiens	179-183
29690733-0	2018	[Experimental study on the effect of hepcidin overexpression on osteoclasts and bone mass in iron accumulation mice].	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	37-45
26560363-4	2015	Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein.	Iron	108-112	ferritin heavy chain 1	Homo sapiens	234-238
26560363-5	2015	In addition, in response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells.	Iron	110-114	ferritin heavy chain 1	Homo sapiens	52-56
26560363-7	2015	Moreover, excess dietary iron caused significant elevation of serum iron levels in p53(-/-) mice.	Iron	25-29	transformation related protein 53, pseudogene	Mus musculus	83-86
28984392-0	2018	Spin-State Energetics of Fe Complexes from an Optimally Tuned Range-Separated Hybrid Functional.	Iron	25-27	spindlin 1	Homo sapiens	0-4
26560363-7	2015	Moreover, excess dietary iron caused significant elevation of serum iron levels in p53(-/-) mice.	Iron	68-72	transformation related protein 53, pseudogene	Mus musculus	83-86
19577392-5	2009	Iron excess is due to deficiencies in either hepcidin or ferroportin, the two key regulatory proteins of iron metabolism.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	45-53
29043483-0	2018	Iron toxicity in yeast: transcriptional regulation of the vacuolar iron importer Ccc1.	Iron	0-4	Ccc1p	Saccharomyces cerevisiae S288C	81-85
29043483-0	2018	Iron toxicity in yeast: transcriptional regulation of the vacuolar iron importer Ccc1.	Iron	67-71	Ccc1p	Saccharomyces cerevisiae S288C	81-85
29043483-5	2018	Iron storage in the vacuole is mediated predominantly by the vacuolar metal importer Ccc1 in yeast and the homologous transporter VIT1 in plants.	Iron	0-4	Ccc1p	Saccharomyces cerevisiae S288C	85-89
29043483-6	2018	Transcription of yeast CCC1 expression is tightly controlled primarily by the transcription factor Yap5, which sits on the CCC1 promoter and activates transcription through the binding of Fe-S clusters.	Iron	188-192	Ccc1p	Saccharomyces cerevisiae S288C	23-27
29043483-10	2018	The identification of multiple independent transcriptional pathways that regulate the levels of Ccc1 under high iron conditions accentuates the importance of protecting cells from the toxic effects of high iron.	Iron	112-116	Ccc1p	Saccharomyces cerevisiae S288C	96-100
29043483-10	2018	The identification of multiple independent transcriptional pathways that regulate the levels of Ccc1 under high iron conditions accentuates the importance of protecting cells from the toxic effects of high iron.	Iron	206-210	Ccc1p	Saccharomyces cerevisiae S288C	96-100
19577392-5	2009	Iron excess is due to deficiencies in either hepcidin or ferroportin, the two key regulatory proteins of iron metabolism.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	45-53
19577392-7	2009	The mainstay of iron overload treatment is venesection therapy in case of hepcidin deficiency, the therapeutic approach for the future being hepcidin supplementation.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	74-82
19342951-4	2009	RECENT FINDINGS: Hepcidin, the iron hormone that is defective in hemochromatosis, is controlled not only by iron signals but also by a number of circulatory and membrane-associated regulators.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	17-25
28918000-2	2018	Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in yeast cells.	Iron	65-69	ferroxidase	Saccharomyces cerevisiae S288C	0-4
28918000-2	2018	Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in yeast cells.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	26-30
28918000-8	2018	This phenomenon is not observed when Aft1 is activated by iron scarcity or impaired iron-sulfur biogenesis.	Iron	58-62	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	37-41
28918000-11	2018	Our hypothesis is that Yfh1 deficiency leads to the presence of anomalous iron species that can compromise iron bioavailability and activate a signaling cascade that results in Aft1 activation and metabolic remodeling.	Iron	74-78	ferroxidase	Saccharomyces cerevisiae S288C	23-27
19342951-4	2009	RECENT FINDINGS: Hepcidin, the iron hormone that is defective in hemochromatosis, is controlled not only by iron signals but also by a number of circulatory and membrane-associated regulators.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	17-25
28918000-11	2018	Our hypothesis is that Yfh1 deficiency leads to the presence of anomalous iron species that can compromise iron bioavailability and activate a signaling cascade that results in Aft1 activation and metabolic remodeling.	Iron	107-111	ferroxidase	Saccharomyces cerevisiae S288C	23-27
34968939-0	2022	Efficient removal of Cd2+ from aqueous solution with a novel composite of silicon supported nano iron/aluminum/magnesium (hydr)oxides prepared from biotite.	Iron	97-101	CD2 molecule	Homo sapiens	21-24
34968939-2	2022	In this study, a composite of silicon supported nano iron/aluminum/magnesium (hydr)oxides was prepared with biotite by combining acid leaching and base precipitation process, which was used to remove Cd2+.	Iron	53-57	CD2 molecule	Homo sapiens	200-203
34942528-0	2022	A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.	Iron	36-40	NLR family pyrin domain containing 6	Homo sapiens	22-27
34942528-4	2022	Here, we demonstrated that NLRP6, a member of the NLR family, has an unconventional role in regulating host iron metabolism that perturbs host resistance to bacterial infection.	Iron	108-112	NLR family pyrin domain containing 6	Homo sapiens	27-32
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	58-62	NLR family pyrin domain containing 6	Homo sapiens	0-5
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	141-145	NLR family pyrin domain containing 6	Homo sapiens	0-5
34942528-5	2022	NLRP6 deficiency is advantageous for maintaining cellular iron homeostasis in both macrophages and enterocytes through increasing the unique iron exporter ferroportin-mediated iron efflux in a nuclear factor erythroid-derived 2-related factor 2 (NRF2)-dependent manner.	Iron	176-180	NLR family pyrin domain containing 6	Homo sapiens	0-5
34942528-8	2022	Together, our observations provide new insights into the mechanism of nutritional immunity by revealing a novel function of NLRP6 in regulating iron metabolism, and suggest NLRP6 as a therapeutic target for limiting bacterial iron acquisition.	Iron	144-148	NLR family pyrin domain containing 6	Homo sapiens	124-129
34942528-8	2022	Together, our observations provide new insights into the mechanism of nutritional immunity by revealing a novel function of NLRP6 in regulating iron metabolism, and suggest NLRP6 as a therapeutic target for limiting bacterial iron acquisition.	Iron	226-230	NLR family pyrin domain containing 6	Homo sapiens	124-129
34942528-8	2022	Together, our observations provide new insights into the mechanism of nutritional immunity by revealing a novel function of NLRP6 in regulating iron metabolism, and suggest NLRP6 as a therapeutic target for limiting bacterial iron acquisition.	Iron	226-230	NLR family pyrin domain containing 6	Homo sapiens	173-178
34965724-0	2022	PPAR-alpha Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer"s Diseases.	Iron	64-68	glutathione peroxidase 4	Mus musculus	81-85
34965724-7	2022	In an in vitro study of APPsw cells, we found that PPAR-alpha directly bound with GPx4 intron3 to promote GPx4 transcription and reduced the iron transport capability.	Iron	141-145	glutathione peroxidase 4	Mus musculus	82-86
34965724-8	2022	Our data suggested that activation of PPAR-alpha by GW7647 improved the disruption of iron homeostasis in the brain of APP/PS1 mice and alleviated neuronal inflammation and lipid peroxidation, which was possibly related to the upregulated transcription of GPx4 mediated by the interaction of GPx4 noncoding region and the PPAR-alpha.	Iron	86-90	glutathione peroxidase 4	Mus musculus	292-296
34962378-2	2022	Herein, we prepared nitrogen-doped carbon-incorporated CoP@Fe-CoP core-shelled nanorod arrays grown on Ni foam (CoP@Fe-CoP/NC/NF) through phosphorization of ZIF-67@Co-Fe Prussian blue analogue (ZIF-67@CoFe-PBA).	Iron	59-61	caspase recruitment domain family member 16	Homo sapiens	55-58
34962378-2	2022	Herein, we prepared nitrogen-doped carbon-incorporated CoP@Fe-CoP core-shelled nanorod arrays grown on Ni foam (CoP@Fe-CoP/NC/NF) through phosphorization of ZIF-67@Co-Fe Prussian blue analogue (ZIF-67@CoFe-PBA).	Iron	59-61	caspase recruitment domain family member 16	Homo sapiens	62-65
34962378-2	2022	Herein, we prepared nitrogen-doped carbon-incorporated CoP@Fe-CoP core-shelled nanorod arrays grown on Ni foam (CoP@Fe-CoP/NC/NF) through phosphorization of ZIF-67@Co-Fe Prussian blue analogue (ZIF-67@CoFe-PBA).	Iron	59-61	caspase recruitment domain family member 16	Homo sapiens	112-115
34962378-2	2022	Herein, we prepared nitrogen-doped carbon-incorporated CoP@Fe-CoP core-shelled nanorod arrays grown on Ni foam (CoP@Fe-CoP/NC/NF) through phosphorization of ZIF-67@Co-Fe Prussian blue analogue (ZIF-67@CoFe-PBA).	Iron	59-61	caspase recruitment domain family member 16	Homo sapiens	119-122
34850509-3	2022	This complex exhibits a 16/18 O2 -isotope sensitive nu(O-O) stretch at 1128 cm-1 concomitantly with a single nu(Fe-O2 ) at 555 cm-1 , indicating it is an eta1 -superoxo ("end-on") iron(III) complex.	Iron	112-114	secreted phosphoprotein 1	Homo sapiens	154-158
34850509-3	2022	This complex exhibits a 16/18 O2 -isotope sensitive nu(O-O) stretch at 1128 cm-1 concomitantly with a single nu(Fe-O2 ) at 555 cm-1 , indicating it is an eta1 -superoxo ("end-on") iron(III) complex.	Iron	180-184	secreted phosphoprotein 1	Homo sapiens	154-158
34469757-4	2022	Ferroptosis is a new type of programmed cell death caused by iron-dependent accumulation of lipid peroxides, in which glutathione peroxidase 4 (GPX4) is a key protein affecting ferroptosis.	Iron	61-65	glutathione peroxidase 4	Mus musculus	144-148
34800783-3	2022	The metabolic disorder of intracellular LOOH catalyzed by iron causes the inactivity of GPX4, disrupts the redox balance, and triggers cell death.	Iron	58-62	glutathione peroxidase 4	Homo sapiens	88-92
34964947-10	2022	Hepcidin treatment resulted in a decrease in ANGPTL4 expression in Caco-2 cells, whereas treatment with an iron chelator restored ANGPTL4 expression in hepcidin-treated cells.	Iron	107-111	angiopoietin like 4	Homo sapiens	130-137
34942595-1	2022	Previous research investigating single bouts of exercise have identified baseline iron status and circulating concentrations of interleukin-6 (IL-6) as contributors to the magnitude of postexercise hepcidin increase.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	198-206
34932791-5	2021	The inherited anemias due to ineffective erythropoiesis are also defined as iron loading anemias because of the associated parenchymal iron loading caused by the release of erythroid factors that suppress hepcidin production.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	205-213
34932791-5	2021	The inherited anemias due to ineffective erythropoiesis are also defined as iron loading anemias because of the associated parenchymal iron loading caused by the release of erythroid factors that suppress hepcidin production.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	205-213
34791391-1	2021	Fe(II) exported from cells is oxidized to Fe(III), possibly by a multi-copper ferroxidase (MCF) such as ceruloplasmin (CP), to efficiently bind with the plasma iron transport protein transferrin (TF).	Iron	160-164	ceruloplasmin	Homo sapiens	104-117
34913799-6	2021	Ret-He and IRF have been established as the marker of iron deficiency and iron-deficiency anaemia in different age groups and as a marker of response to iron therapy.	Iron	153-157	ret proto-oncogene	Homo sapiens	0-3
34846399-0	2021	Construction of Fe-doped CoP with hybrid nanostructures as a bifunctional catalyst for overall water splitting.	Iron	16-18	caspase recruitment domain family member 16	Homo sapiens	25-28
34755596-5	2021	Its differential diagnosis includes iron-refractory iron deficiency anemia (IRIDA), a rare congenital disease in which the hepcidin level is pathologically elevated, as well as the more common anemia of chronic disease (anemia of chronic inflammation), in which increased amounts of hepcidin are formed under the influence of interleukin-6 and enteric iron uptake is blocked as a result.	Iron	352-356	hepcidin antimicrobial peptide	Homo sapiens	123-131
34755596-5	2021	Its differential diagnosis includes iron-refractory iron deficiency anemia (IRIDA), a rare congenital disease in which the hepcidin level is pathologically elevated, as well as the more common anemia of chronic disease (anemia of chronic inflammation), in which increased amounts of hepcidin are formed under the influence of interleukin-6 and enteric iron uptake is blocked as a result.	Iron	352-356	hepcidin antimicrobial peptide	Homo sapiens	283-291
34755596-8	2021	CONCLUSION: Our improving understanding of the molecular pathophysiology of iron metabolism aids in the evaluation of iron deficiency and iron overload and may in future enable treatment not just with iron supplementation or iron chelation, but also with targeted pharmacological modulation of the hepcidin regulatory system.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	298-306
34762398-1	2021	We report the crystal structure of the mammalian non-heme iron enzyme cysteamine dioxygenase (ADO) at 1.9 A resolution, which shows an Fe and three-histidine (3-His) active site situated at the end of a wide substrate access channel.	Iron	135-137	2-aminoethanethiol dioxygenase	Homo sapiens	70-92
34762398-1	2021	We report the crystal structure of the mammalian non-heme iron enzyme cysteamine dioxygenase (ADO) at 1.9 A resolution, which shows an Fe and three-histidine (3-His) active site situated at the end of a wide substrate access channel.	Iron	135-137	2-aminoethanethiol dioxygenase	Homo sapiens	94-97
34762398-6	2021	Notably, the Cys and tyrosine residues shown to be capable of forming a cross-link in human ADO reside ~7 A from the iron center.	Iron	117-121	2-aminoethanethiol dioxygenase	Homo sapiens	92-95
34793140-2	2021	ZIP transporters have been shown to transport different divalent metal ions including zinc, iron, manganese, and cadmium.	Iron	92-96	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	0-3
30209431-7	2018	Studies also demonstrate high bioavailability of limiting nutrients, such as vitamin A, iron, zinc and fatty acids in the ASF matrix, ensuring efficient absorption and metabolism.	Iron	88-92	arylsulfatase F	Homo sapiens	122-125
34793140-10	2021	The binuclear zinc-iron binding center in ZupT has likely evolved to enable the transport of essential metals from two different sites without competition; a similar mechanism of metal transport is likely to be found in the gufA subfamily of ZIP transporter proteins.	Iron	19-23	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	242-245
34959389-13	2021	The mRNAs encoding HTT, APP and alphaSYN contain an atypical iron response element (IRE) in their 5"-untranslated regions (5"-UTRs) that bind iron regulatory protein 1 (IRP1), and Posiphen specifically bound this complex.	Iron	61-65	synuclein alpha	Homo sapiens	32-40
29566031-12	2018	Using FE based detection of MMPs in the anastomosis, an overall positive predictive value of 71.4% and negative predictive value of 66.6% was calculated for detection of anastomotic leakage.	Iron	6-8	matrix metallopeptidase 2	Mus musculus	28-32
34861039-7	2022	Our study demonstrates that coordinated mis-splicing of mitochondrial transporters TMEM14C and ABCB7 by mutant SF3B1 sequesters iron in mitochondria, causing ring sideroblast formation.	Iron	128-132	ATP binding cassette subfamily B member 7	Homo sapiens	95-100
34596731-4	2021	Reduction of Fe(III) by ascorbate is important for cellular uptake of iron via DMT1.	Iron	70-74	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
29610598-1	2018	BACKGROUND: Proton pump inhibitors (PPIs) represent the most widely prescribed antisecretory agents, but their prolonged use, may influence iron and vitamin B12 status, which could have important implications for clinical practice.	Iron	140-144	ATPase H+/K+ transporting subunit alpha	Homo sapiens	12-23
29305420-7	2018	Mfrn1 was incorporated into defined liposomes, and iron transport was reconstituted in vitro, demonstrating that Mfrn1 can transport iron.	Iron	133-137	solute carrier family 25 member 37	Homo sapiens	113-118
29305420-9	2018	Experiments with candidate ligands for cellular labile iron reveal that Mfrn1 transports free iron and not a chelated iron complex and selects against alkali divalent ions.	Iron	55-59	solute carrier family 25 member 37	Homo sapiens	72-77
34369274-12	2021	Moreover, TFRC activated PTEN induced kinase 1 (PINK1) signaling and induced mitophagy; iron-uptake-induced upregulation of acyl-CoA synthetase long chain family member 4 (ACSL4) was required for mitophagy activation and glutathione peroxidase 4 (GPX4) degradation.	Iron	88-92	glutathione peroxidase 4	Homo sapiens	221-245
29305420-9	2018	Experiments with candidate ligands for cellular labile iron reveal that Mfrn1 transports free iron and not a chelated iron complex and selects against alkali divalent ions.	Iron	94-98	solute carrier family 25 member 37	Homo sapiens	72-77
29305420-9	2018	Experiments with candidate ligands for cellular labile iron reveal that Mfrn1 transports free iron and not a chelated iron complex and selects against alkali divalent ions.	Iron	94-98	solute carrier family 25 member 37	Homo sapiens	72-77
34369274-12	2021	Moreover, TFRC activated PTEN induced kinase 1 (PINK1) signaling and induced mitophagy; iron-uptake-induced upregulation of acyl-CoA synthetase long chain family member 4 (ACSL4) was required for mitophagy activation and glutathione peroxidase 4 (GPX4) degradation.	Iron	88-92	glutathione peroxidase 4	Homo sapiens	247-251
34611951-0	2021	Runx3 regulates iron metabolism via modulation of BMP signalling.	Iron	16-20	bone morphogenetic protein 1	Homo sapiens	50-53
28350201-0	2018	A role for sex and a common HFE gene variant in brain iron uptake.	Iron	54-58	homeostatic iron regulator	Mus musculus	28-31
28350201-1	2018	HFE (high iron) is an essential protein for regulating iron transport into cells.	Iron	10-14	homeostatic iron regulator	Mus musculus	0-3
28350201-1	2018	HFE (high iron) is an essential protein for regulating iron transport into cells.	Iron	55-59	homeostatic iron regulator	Mus musculus	0-3
28350201-2	2018	Mutations of the HFE gene result in loss of this regulation causing accumulation of iron within the cell.	Iron	84-88	homeostatic iron regulator	Mus musculus	17-20
28350201-5	2018	While much has been studied regarding the role of HFE in cellular iron uptake, it has remained unclear what role the protein plays in the transport of iron into the brain.	Iron	66-70	homeostatic iron regulator	Mus musculus	50-53
34611951-9	2021	Transcriptome analysis on primary hepatocytes isolated from Runx3 cKO mice also revealed that iron-induced increase in BMP6 was mediated by Runx3.	Iron	94-98	bone morphogenetic protein 6	Mus musculus	119-123
28350201-6	2018	We investigated regulation of iron transport into the brain using a mouse model with a mutation in the HFE gene.	Iron	30-34	homeostatic iron regulator	Mus musculus	103-106
34611951-11	2021	Finally, we showed that Runx3 enhanced the activity of the BMP6 promoter by responding to iron stimuli in the hepatocytes.	Iron	90-94	RUNX family transcription factor 3	Homo sapiens	24-29
34611951-12	2021	CONCLUSION: In conclusion, we suggest that Runx3 plays important roles in iron metabolism of the liver through regulation of BMP signalling.	Iron	74-78	RUNX family transcription factor 3	Homo sapiens	43-48
34675995-0	2021	Reduced hepcidin expression enhances iron overload in patients with HbE/beta-thalassemia: Alpha comparative cross-sectional study.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	8-16
29234149-9	2018	Both hippocampal volumes and serum BDNF concentrations of neonates born to iron-deficient mothers were significantly reduced compared to controls.	Iron	75-79	brain derived neurotrophic factor	Homo sapiens	35-39
34675995-1	2021	Iron homeostasis is regulated by hepcidin (HEPC) that controls the dietary iron absorption and iron recycling.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	33-41
29467298-5	2018	The role of iron in A. fumigatus invasive growth was further confirmed by showing that this invasive phenotype was increased in tracheal transplants from donor mice lacking the hemochromatosis gene (Hfe-/- ).	Iron	12-16	homeostatic iron regulator	Mus musculus	199-202
34675995-1	2021	Iron homeostasis is regulated by hepcidin (HEPC) that controls the dietary iron absorption and iron recycling.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	43-47
34675995-1	2021	Iron homeostasis is regulated by hepcidin (HEPC) that controls the dietary iron absorption and iron recycling.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	33-41
34675995-1	2021	Iron homeostasis is regulated by hepcidin (HEPC) that controls the dietary iron absorption and iron recycling.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	43-47
29381341-2	2018	The combination of iron with the non-innocent bis(imino)pyridine ligand permits comparison of catalytic activity as a function of oxidation state (and overall spin state).	Iron	19-23	spindlin 1	Homo sapiens	159-163
34675995-1	2021	Iron homeostasis is regulated by hepcidin (HEPC) that controls the dietary iron absorption and iron recycling.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	33-41
34675995-1	2021	Iron homeostasis is regulated by hepcidin (HEPC) that controls the dietary iron absorption and iron recycling.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	43-47
29384663-5	2018	Additionally, determination of the spin state of iron is possible by comparing the characteristic shifts of spin and oxidation-state-sensitive marker bands in the Raman spectrum with calculations of planar porphyrin model structures.	Iron	49-53	spindlin 1	Homo sapiens	35-39
34675995-3	2021	The present study aimed to investigate the correlation between HEPC concentration and serum iron status among hemoglobin E (HbE)/beta-thalassemia patients and their parents (HbE trait and beta-thalassemia trait) compared with healthy controls.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	63-67
29384663-5	2018	Additionally, determination of the spin state of iron is possible by comparing the characteristic shifts of spin and oxidation-state-sensitive marker bands in the Raman spectrum with calculations of planar porphyrin model structures.	Iron	49-53	spindlin 1	Homo sapiens	108-112
34675995-11	2021	These findings supported the hypothesis that downregulated HEPC could lose its function as a negative regulator of FPN1, resulting in iron overload in HbE/beta-thalassemia patients.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	59-63
29491838-8	2018	A biochemically active Fe-S core complex of heterologously expressed fly Nfs1, Isd11, IscU, and human frataxin is presented.	Iron	23-27	Iron-sulfur cluster assembly enzyme	Drosophila melanogaster	86-90
34675995-11	2021	These findings supported the hypothesis that downregulated HEPC could lose its function as a negative regulator of FPN1, resulting in iron overload in HbE/beta-thalassemia patients.	Iron	134-138	solute carrier family 40 member 1	Homo sapiens	115-119
34675995-12	2021	Subsequently, assessing HEPC and FPN1 gene expression may be a useful tool to determine the risk of iron toxicity in patients with HbE/beta-thalassemia and their parents, and could therefore be considered as a therapeutic target in the management of iron burden in these patients.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	24-28
29208364-4	2018	Exposure of macrophages to dopamine increased the uptake of non-transferrin bound iron into cells.	Iron	82-86	transferrin	Mus musculus	64-75
34675995-12	2021	Subsequently, assessing HEPC and FPN1 gene expression may be a useful tool to determine the risk of iron toxicity in patients with HbE/beta-thalassemia and their parents, and could therefore be considered as a therapeutic target in the management of iron burden in these patients.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	33-37
34537856-8	2021	RESULTS: A positively correlation was showed among the levels of GPX4, iron and cell proliferation.	Iron	71-75	glutathione peroxidase 4	Mus musculus	65-69
29285663-1	2018	Neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (Lf) are among the key components of the innate immune system due to their ability to bind iron with high affinity and thus control inflammation.	Iron	157-161	lipocalin 2	Homo sapiens	0-42
29285663-1	2018	Neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (Lf) are among the key components of the innate immune system due to their ability to bind iron with high affinity and thus control inflammation.	Iron	157-161	lipocalin 2	Homo sapiens	44-48
34537856-14	2021	Importantly, inhibition of GPX4 interferes with both intracellular iron homeostasis and lipid peroxide reducibility, inducing ferroptosis and exerting anti-cancer effect, which can be a potential effective strategy for ovarian cancer therapy.	Iron	67-71	glutathione peroxidase 4	Mus musculus	27-31
29285663-7	2018	NGAL and Lf measured in meconium are candidate biomarkers for fetal iron status.	Iron	68-72	lipocalin 2	Homo sapiens	0-4
34347207-1	2021	Aceruloplasminemia (ACP) is a rare disorder of iron overload resulting from ceruloplasmin (CP) variants.	Iron	47-51	ceruloplasmin	Homo sapiens	76-89
28389813-0	2018	Plasma neutrophil gelatinase-associated lipocalin is associated with iron status in anemic patients with pre-dialysis chronic kidney disease.	Iron	69-73	lipocalin 2	Homo sapiens	7-49
28389813-2	2018	Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of acute kidney injury, is known to be associated with iron metabolism.	Iron	118-122	lipocalin 2	Homo sapiens	0-42
34347207-1	2021	Aceruloplasminemia (ACP) is a rare disorder of iron overload resulting from ceruloplasmin (CP) variants.	Iron	47-51	ceruloplasmin	Homo sapiens	91-93
28389813-2	2018	Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of acute kidney injury, is known to be associated with iron metabolism.	Iron	118-122	lipocalin 2	Homo sapiens	44-48
28389813-3	2018	We investigated whether plasma NGAL level is associated with iron status in pre-dialysis CKD patients with anemia.	Iron	61-65	lipocalin 2	Homo sapiens	31-35
34224321-9	2021	These observations suggest that upregulation of brain hepcidin plays a significant role in iron accumulation and associated neurotoxicity in human and animal prion disorders.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	54-62
28389813-12	2018	CONCLUSIONS: Plasma NGAL is associated with iron status in anemic patients with pre-dialysis CKD.	Iron	44-48	lipocalin 2	Homo sapiens	20-24
29165044-7	2018	The iron contents in the MCF-7 and CT-26 cells were 33.1 +- 1.8 and 27.9 +- 0.95 pg, respectively, after co-incubation with LyP-1-SPIONs for 8 h. The LyP-1-SPIONs accumulated in the nucleus of MCF-7 cells while PEG-SPIONs in cytoplasma.	Iron	4-8	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	124-129
29165044-7	2018	The iron contents in the MCF-7 and CT-26 cells were 33.1 +- 1.8 and 27.9 +- 0.95 pg, respectively, after co-incubation with LyP-1-SPIONs for 8 h. The LyP-1-SPIONs accumulated in the nucleus of MCF-7 cells while PEG-SPIONs in cytoplasma.	Iron	4-8	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	150-155
34951249-3	2021	Hepcidin is an important target regulating iron metabolism.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
29386206-5	2018	Choroid plexus epithelial cells also contain iron-responsive element-binding proteins (IRPs), IRP1, and IRP2 that bind to mRNA iron-responsive elements.	Iron	127-131	iron responsive element binding protein 2	Rattus norvegicus	104-108
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	136-144
34873429-11	2021	Renal erythropoietin expression and serum erythroferrone concentration were lower in CFA-iron rats than those in control rats.	Iron	89-93	erythropoietin	Rattus norvegicus	6-20
34894263-3	2022	bHLH11 is a negative TF that regulates Fe homeostasis.	Iron	39-41	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-6
29445391-2	2017	Previously we identified dZIP13 (CG7816), a member of the ZIP transporter family (SLC39A) and presumably a zinc importer, is in fact physiologically primarily responsible to move iron from the cytosol into the secretory compartments in the fly.	Iron	179-183	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	25-31
29382887-5	2018	The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues.	Iron	4-6	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	106-117
34894263-5	2022	Here, we generated two loss-of-function bhlh11 mutants in Arabidopsis (Arabidopsis thaliana), which display enhanced sensitivity to excess Fe, increased Fe accumulation, and elevated expression of Fe deficiency responsive genes.	Iron	139-141	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	40-46
29291145-4	2018	Thus, the aim of the current study is to understand the role of iron in biofilm formation and deformylase activity of PDF.	Iron	64-68	peptide deformylase (mitochondrial)	Rattus norvegicus	118-121
34894263-5	2022	Here, we generated two loss-of-function bhlh11 mutants in Arabidopsis (Arabidopsis thaliana), which display enhanced sensitivity to excess Fe, increased Fe accumulation, and elevated expression of Fe deficiency responsive genes.	Iron	153-155	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	40-46
29291145-6	2018	The deformylase activity of the purified recombinant PDF was measured in culture supplemented with/without iron where the purified rPDF showed Km of 1.3 mM and Vmax of 0.035 mM/mg/min, which was close to the native PDF (Km = 1.4 mM, Vmax = 0.030 mM/mg/min).	Iron	107-111	peptide deformylase (mitochondrial)	Rattus norvegicus	53-56
29291145-6	2018	The deformylase activity of the purified recombinant PDF was measured in culture supplemented with/without iron where the purified rPDF showed Km of 1.3 mM and Vmax of 0.035 mM/mg/min, which was close to the native PDF (Km = 1.4 mM, Vmax = 0.030 mM/mg/min).	Iron	107-111	peptide deformylase (mitochondrial)	Rattus norvegicus	131-135
29291145-6	2018	The deformylase activity of the purified recombinant PDF was measured in culture supplemented with/without iron where the purified rPDF showed Km of 1.3 mM and Vmax of 0.035 mM/mg/min, which was close to the native PDF (Km = 1.4 mM, Vmax = 0.030 mM/mg/min).	Iron	107-111	peptide deformylase (mitochondrial)	Rattus norvegicus	132-135
29291145-7	2018	Interestingly, the Km decreased and PDF activity increased when the culture was supplemented with iron, corroborating with qPCR results showing 100- to 150-fold more expression compared to control in S. aureus and its drug-resistant strains.	Iron	98-102	peptide deformylase (mitochondrial)	Rattus norvegicus	36-39
34894263-10	2022	Correspondingly, the expression of Fe uptake genes increased in the tpr1 tpr4 tpl mutant.	Iron	35-37	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	68-72
34894263-10	2022	Correspondingly, the expression of Fe uptake genes increased in the tpr1 tpr4 tpl mutant.	Iron	35-37	Transducin family protein / WD-40 repeat family protein	Arabidopsis thaliana	78-81
34824033-1	2022	Hemochromatosis is currently characterized by the iron overload caused by hepcidin deficiency.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	74-82
29032057-10	2018	To our knowledge, Hog1p is the first kinase reported to directly regulate Aft1p, impacting on iron homeostasis.	Iron	94-98	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	74-79
29158088-3	2018	In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	131-139
29158088-3	2018	In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.	Iron	165-169	hepcidin antimicrobial peptide	Mus musculus	131-139
29158088-5	2018	Hamp mRNA levels were significantly correlated with hepatic iron content and BMP6 mRNA levels.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	0-4
29158088-6	2018	Hepatic iron content was associated with the increase in mRNA levels of divalent metal transporter 1 and transferrin receptor.	Iron	8-12	transferrin	Mus musculus	105-116
34214820-7	2021	In addition, XPS results demonstrated the dominant role of S(-II) with the increase of Fe(II) from 36.3% to 58.6% and decrease of Fe(III) from 52.1% to 39.8% in the PS/S-FeNi@BC system.	Iron	87-89	transcription elongation factor A1	Homo sapiens	59-64
29843136-0	2018	The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing Mice.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	98-106
34214820-7	2021	In addition, XPS results demonstrated the dominant role of S(-II) with the increase of Fe(II) from 36.3% to 58.6% and decrease of Fe(III) from 52.1% to 39.8% in the PS/S-FeNi@BC system.	Iron	130-132	transcription elongation factor A1	Homo sapiens	59-64
29843136-3	2018	Hepcidin secreted by liver plays an essential role in orchestrating iron metabolism.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
34804985-0	2021	Pivotal Role of Iron Homeostasis in the Induction of Mitochondrial Apoptosis by 6-Gingerol Through PTEN Regulated PD-L1 Expression in Embryonic Cancer Cells.	Iron	16-20	CD274 molecule	Homo sapiens	114-119
29112723-6	2018	Cell lines with CHCHD10 knockdown do not display bioenergetic defects, but, unexpectedly, accumulate excessive intramitochondrial iron.	Iron	130-134	coiled-coil-helix-coiled-coil-helix domain containing 10	Mus musculus	16-23
34311475-6	2021	METHODS: In this work, we have investigated an ALK inhibitor LDN193189 for its efficacy in iron homeostasis.	Iron	91-95	anaplastic lymphoma kinase	Mus musculus	47-50
30652514-3	2018	The amino acid sequence of this clone, designated CjNRAMP1, was similar to the sequence of Arabidopsis AtNRAMP1, which is involved in Fe and Cd transport.	Iron	134-136	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	103-111
28935635-0	2018	Serpinb3 is overexpressed in the liver in presence of iron overload.	Iron	54-58	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	0-8
34594405-6	2021	Hepcidin is a small peptide hormone that functions as a negative regulator of intestinal iron absorption.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
28935635-3	2018	Aim of the present study was to assess the effect of iron overload on SerpinB3 expression in the liver using in vivo and in vitro models.The expression of Serpinb3 was assessed in the liver of hemojuvelin knockout mice (Hjv-/-), an established model of hereditary hemochromatosis, and of wild type control mice, following dietary or pharmacological iron manipulation.	Iron	53-57	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	70-78
28935635-4	2018	To assess the direct effect of iron in vitro, cell lines were treated with different concentration of hemin or with an iron chelator.Hepatic Serpinb3 mRNA and protein were highly expressed in Hjv-/- mice, but not in wild type controls fed with a standard diet.	Iron	31-35	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	141-149
28935635-4	2018	To assess the direct effect of iron in vitro, cell lines were treated with different concentration of hemin or with an iron chelator.Hepatic Serpinb3 mRNA and protein were highly expressed in Hjv-/- mice, but not in wild type controls fed with a standard diet.	Iron	119-123	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	141-149
28935635-5	2018	Serpinb3 became detectable in wild type mice fed with a high iron diet or injected with iron dextran; these treatments further induced Serpinb3 expression in Hjv-/- mice.	Iron	61-65	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	0-8
28935635-8	2018	In conclusion, Serpinb3 is strongly induced by iron in the mouse liver.	Iron	47-51	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	15-23
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	Iron	27-31	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	41-49
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	Iron	27-31	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	158-166
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	Iron	94-98	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	41-49
29444509-0	2018	Associations Between Intravenous Iron, Inflammation and FGF23 in Non-Dialysis Patients with Chronic Kidney Disease Stages 3-5.	Iron	33-37	fibroblast growth factor 23	Homo sapiens	56-61
29444509-13	2018	CONCLUSION: Intravenous iron supplementation may only transiently affect the production and degradation of FGF23 resulting in hypophosphatemia at the commencement of iron therapy.	Iron	24-28	fibroblast growth factor 23	Homo sapiens	107-112
29444509-13	2018	CONCLUSION: Intravenous iron supplementation may only transiently affect the production and degradation of FGF23 resulting in hypophosphatemia at the commencement of iron therapy.	Iron	166-170	fibroblast growth factor 23	Homo sapiens	107-112
34594405-7	2021	Significant body weight loss in overweight and obese individuals decreases chronic inflammation and serum hepcidin levels, resulting in improved iron status due to increased iron absorption.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	106-114
34594405-7	2021	Significant body weight loss in overweight and obese individuals decreases chronic inflammation and serum hepcidin levels, resulting in improved iron status due to increased iron absorption.	Iron	174-178	hepcidin antimicrobial peptide	Homo sapiens	106-114
34716241-5	2021	RESULTS: We found that kidney cells and tissues lacking Pkd1 exhibit extensive metabolic abnormalities, including reduced expression of the system Xc- amino acid antiporter (critical for import of cystine), of iron exporter (ferroportin), and of GPX4 (a key and negative regulator of ferroptosis).	Iron	210-214	polycystin 1, transient receptor potential channel interacting	Mus musculus	56-60
29746238-1	2018	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism.	Iron	99-103	aconitase 1	Mus musculus	0-32
29746238-1	2018	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism.	Iron	99-103	aconitase 1	Mus musculus	34-38
29746238-1	2018	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism.	Iron	99-103	iron responsive element binding protein 2	Mus musculus	43-47
29746238-1	2018	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism.	Iron	166-170	aconitase 1	Mus musculus	0-32
29746238-1	2018	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism.	Iron	166-170	aconitase 1	Mus musculus	34-38
29746238-1	2018	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism.	Iron	166-170	iron responsive element binding protein 2	Mus musculus	43-47
34707288-6	2021	Cells lacking both SLC25A39 and its paralogue SLC25A40 exhibit defects in the activity and stability of proteins containing iron-sulfur clusters.	Iron	124-128	solute carrier family 25 member 39	Homo sapiens	19-27
29746241-4	2018	However, in the two decades subsequent to the initial discovery, purification and in vitro analysis of bacterial MutYs and mammalian homologs, such as human MUTYH and mouse Mutyh, have demonstrated that proper Fe-S cluster coordination is required for OG:A substrate recognition and adenine excision.	Iron	210-214	mutY DNA glycosylase	Homo sapiens	157-162
29746241-4	2018	However, in the two decades subsequent to the initial discovery, purification and in vitro analysis of bacterial MutYs and mammalian homologs, such as human MUTYH and mouse Mutyh, have demonstrated that proper Fe-S cluster coordination is required for OG:A substrate recognition and adenine excision.	Iron	210-214	mutY DNA glycosylase	Mus musculus	173-178
29746241-8	2018	The methods described herein have not only been leveraged to provide insight into the roles of the MutY Fe-S cluster but have also been provided crucial information needed to delineate the impact of inherited variants of the human homolog MUTYH associated with a colorectal cancer syndrome known as MUTYH-associated polyposis or MAP.	Iron	104-108	mutY DNA glycosylase	Homo sapiens	239-244
29746241-9	2018	Notably, many MAP-associated variants have been found adjacent to the Fe-S cluster further underscoring the intimate relationship between the cofactor, MUTYH-mediated DNA repair, and disease.	Iron	70-74	mutY DNA glycosylase	Homo sapiens	152-157
29115497-1	2018	Hepcidin is one of the most important proteins in iron metabolism.	Iron	50-54	hepcidin antimicrobial peptide	Mus musculus	0-8
29115497-7	2018	Collectively, the results of the present study indicated that hepcidin is involved in iron metabolism in IRS-1-/- mice via the signaling pathways involving BMP6 and IL-6.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	62-70
29115497-8	2018	Furthermore, hepcidin is also involved in iron metabolism in osteoblasts under iron overload conditions.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	13-21
34549997-13	2021	Here, we use the innate immune protein calprotectin (CP), which complexes with several metals, including iron (Fe), zinc (Zn), and manganese (Mn), and the opportunistic pathogen Pseudomonas aeruginosa to investigate multimetal starvation.	Iron	105-109	ceruloplasmin	Homo sapiens	39-51
29115497-8	2018	Furthermore, hepcidin is also involved in iron metabolism in osteoblasts under iron overload conditions.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	13-21
29115497-9	2018	Therefore, hepcidin and its associated signaling pathway proteins may represent potential targets for the treatment of conditions associated with iron overload.	Iron	146-150	hepcidin antimicrobial peptide	Mus musculus	11-19
34549997-13	2021	Here, we use the innate immune protein calprotectin (CP), which complexes with several metals, including iron (Fe), zinc (Zn), and manganese (Mn), and the opportunistic pathogen Pseudomonas aeruginosa to investigate multimetal starvation.	Iron	111-113	ceruloplasmin	Homo sapiens	39-51
34718778-0	2022	Protein lipoylation in mitochondria requires Fe-S cluster assembly factors NFU4 and NFU5.	Iron	45-49	NFU domain protein 4	Arabidopsis thaliana	75-79
29169913-8	2018	We then describe the ATP13A2-involvement in iron homeostasis and its potential linkage with new pathologies like cancer, and finally, we consider the putative role of ATP13A2 in lipid processing and degradation, opening the interesting possibility of a broader role of this protein providing protection against a variety of disease-associated changes affecting cellular homeostasis.	Iron	44-48	ATPase cation transporting 13A2	Homo sapiens	21-28
34718778-2	2022	"Plastid-type" NFU1, NFU2 and NFU3 in Arabidopsis (Arabidopsis thaliana) play a role in iron-sulfur (Fe-S) cluster assembly in this organelle, whereas the type-II NFU4 and NFU5 proteins have not been subjected to mutant studies in any plant species to determine their biological role.	Iron	101-105	NFU domain protein 1	Arabidopsis thaliana	15-19
29032170-4	2018	The results showed that the optimal conditions predicted by the model without defining any restrictions are: pH=2.0, Po=120W, ZVI=24mgL-1, which provide total salicyclic acid and 48% TOC decay.	Iron	126-129	LLGL scribble cell polarity complex component 1	Homo sapiens	132-137
34827241-3	2021	The commonly observed iron-uptake genes were feoB (94%), sitA (83%), and iutA (58%).	Iron	22-26	SitA	Escherichia coli	57-61
29595455-1	2018	Objective To observe the effect of alpha-lipoic acid (alpha-LA) on the expressions of iron regulatory protein 2 (IRP2) and ferroportin1 (FP1) in substantia nigra of rats with Parkinson"s disease (PD) and explore the mechanism by which alpha-LA regulates iron efflux in substantia nigra cells of PD rat models.	Iron	86-90	iron responsive element binding protein 2	Rattus norvegicus	113-117
34816089-6	2021	The aim of this work was to determine the effect of bovine iron-free Lf (apo-BLf) on the production and secretion of proteases into culture supernatant (CS) and on their release in OMVs.	Iron	59-63	citrate synthase	Bos taurus	153-155
29399416-0	2018	Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment.	Iron	42-46	lipocalin 2	Homo sapiens	19-30
34265052-9	2021	Cellular iron-loading caused a marked increase in CD63 expression and the secretion from cells of CD63 positive (i.e., CD63(+)) EVs, which were shown to contain ferritin-H (FtH) and -L (FtL).	Iron	9-13	CD63 molecule	Homo sapiens	119-123
29399416-4	2018	Mechanistically, TAM expressed elevated levels of the high-affinity iron-binding protein lipocalin-2 (LCN-2), which appeared to be critical for the export of iron from TAM, and in turn enhanced tumor cell proliferation.	Iron	68-72	lipocalin 2	Homo sapiens	89-100
29399416-4	2018	Mechanistically, TAM expressed elevated levels of the high-affinity iron-binding protein lipocalin-2 (LCN-2), which appeared to be critical for the export of iron from TAM, and in turn enhanced tumor cell proliferation.	Iron	68-72	lipocalin 2	Homo sapiens	102-107
29399416-4	2018	Mechanistically, TAM expressed elevated levels of the high-affinity iron-binding protein lipocalin-2 (LCN-2), which appeared to be critical for the export of iron from TAM, and in turn enhanced tumor cell proliferation.	Iron	158-162	lipocalin 2	Homo sapiens	89-100
29399416-4	2018	Mechanistically, TAM expressed elevated levels of the high-affinity iron-binding protein lipocalin-2 (LCN-2), which appeared to be critical for the export of iron from TAM, and in turn enhanced tumor cell proliferation.	Iron	158-162	lipocalin 2	Homo sapiens	102-107
29399416-8	2018	Targeting the LCN-2 iron export mechanism selectively in stromal cells might open for future iron-targeted tumor therapeutic approaches.	Iron	20-24	lipocalin 2	Homo sapiens	14-19
29399416-8	2018	Targeting the LCN-2 iron export mechanism selectively in stromal cells might open for future iron-targeted tumor therapeutic approaches.	Iron	93-97	lipocalin 2	Homo sapiens	14-19
34265052-9	2021	Cellular iron-loading caused a marked increase in CD63 expression and the secretion from cells of CD63 positive (i.e., CD63(+)) EVs, which were shown to contain ferritin-H (FtH) and -L (FtL).	Iron	9-13	ferritin heavy chain 1	Homo sapiens	161-171
29165461-1	2017	Two rare chiral mixed-valence iron(ii,iii) coordination networks d-and l-{[FeIIFeO(BTC)3(DEF)3] 0.5H2O}n (d-1 and l-1) (H3BTC = 1,3,5-benzenetricarboxylic acid; DEF = N,N-diethylformamide) have been synthesized without any chiral auxiliary under the solvothermal conditions and structurally characterized by single crystal X-ray crystallography.	Iron	30-34	UTP25 small subunit processome component	Homo sapiens	89-92
34265052-9	2021	Cellular iron-loading caused a marked increase in CD63 expression and the secretion from cells of CD63 positive (i.e., CD63(+)) EVs, which were shown to contain ferritin-H (FtH) and -L (FtL).	Iron	9-13	ferritin heavy chain 1	Homo sapiens	173-176
34265052-10	2021	Our results demonstrate that under iron-loading, intracellular ferritin is transferred via nuclear receptor coactivator 4 (NCOA4) to CD63(+) EVs that are then secreted.	Iron	35-39	CD63 molecule	Homo sapiens	133-137
34265052-11	2021	Such iron-regulated secretion of the major iron storage protein ferritin via CD63(+) EVs, poses significant impact for understanding the local cell-to-cell exchange of ferritin and iron.	Iron	5-9	CD63 molecule	Homo sapiens	77-81
34265052-11	2021	Such iron-regulated secretion of the major iron storage protein ferritin via CD63(+) EVs, poses significant impact for understanding the local cell-to-cell exchange of ferritin and iron.	Iron	43-47	CD63 molecule	Homo sapiens	77-81
29257745-1	2017	Friedreich"s ataxia (FRDA), the most common inherited ataxia, is caused by recessive mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein.	Iron	153-157	frataxin	Mus musculus	121-129
34265052-11	2021	Such iron-regulated secretion of the major iron storage protein ferritin via CD63(+) EVs, poses significant impact for understanding the local cell-to-cell exchange of ferritin and iron.	Iron	181-185	CD63 molecule	Homo sapiens	77-81
29257745-1	2017	Friedreich"s ataxia (FRDA), the most common inherited ataxia, is caused by recessive mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein.	Iron	153-157	frataxin	Mus musculus	131-134
34343376-0	2021	Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.	Iron	0-4	ferritin mitochondrial	Homo sapiens	46-68
34343376-4	2021	To better investigate its ferroxidase properties, here we performed time-lapse X-ray crystallography analysis of hMTF, providing structural evidence of how iron ions interact with hMTF and of their binding to the FS.	Iron	156-160	ferritin mitochondrial	Homo sapiens	113-117
29247132-0	2017	The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase.	Iron	63-67	ferrochelatase	Homo sapiens	132-146
34343376-4	2021	To better investigate its ferroxidase properties, here we performed time-lapse X-ray crystallography analysis of hMTF, providing structural evidence of how iron ions interact with hMTF and of their binding to the FS.	Iron	156-160	ferritin mitochondrial	Homo sapiens	180-184
34668514-3	2021	2-oxoglutarate- and iron-dependent oxygenase domain-containing protein 1 (Ogfod1), which hydroxylates a proline in ribosomal protein s23 is a newly-described member of this family.	Iron	20-24	2-oxoglutarate and iron-dependent oxygenase domain containing 1	Mus musculus	74-80
29079471-1	2017	Hepcidin has emerged as the central regulatory molecule in systemic iron homeostasis, and its inhibition could be a favorable strategy for treating anemia of chronic disease (ACD).	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
34562083-7	2021	Compared with the control group, the serum of iron-overload mice exhibited low levels of urea nitrogen and high-density lipoprotein (HDL), and high concentrations of total bile acid, low-density lipoprotein (LDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH), suggestive of liver injury.	Iron	46-50	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	214-240
34562083-7	2021	Compared with the control group, the serum of iron-overload mice exhibited low levels of urea nitrogen and high-density lipoprotein (HDL), and high concentrations of total bile acid, low-density lipoprotein (LDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH), suggestive of liver injury.	Iron	46-50	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	242-245
28833753-11	2017	Iron-saturated Lf (holo-Lf) increased TE expression and promoted Akt1 phosphorylation, when compared to those parameters in cells treated with iron-free Lf (apo-Lf).	Iron	0-4	elastin	Homo sapiens	38-40
34562083-7	2021	Compared with the control group, the serum of iron-overload mice exhibited low levels of urea nitrogen and high-density lipoprotein (HDL), and high concentrations of total bile acid, low-density lipoprotein (LDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH), suggestive of liver injury.	Iron	46-50	glutamic pyruvic transaminase, soluble	Mus musculus	248-272
34562083-7	2021	Compared with the control group, the serum of iron-overload mice exhibited low levels of urea nitrogen and high-density lipoprotein (HDL), and high concentrations of total bile acid, low-density lipoprotein (LDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH), suggestive of liver injury.	Iron	46-50	glutamic pyruvic transaminase, soluble	Mus musculus	274-277
28726524-0	2017	Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration.	Iron	104-108	monoamine oxidase B	Homo sapiens	71-76
34171817-0	2021	Sensitive detection of prostate-specific antigen based on dual signal amplification of Fc@MgAl-LDH and NH2-MIL-101(Fe).	Iron	115-117	kallikrein related peptidase 3	Homo sapiens	23-48
28990200-3	2017	We aimed to explore if ABO blood group is associated with iron stores expressed as ferritin levels.	Iron	58-62	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	23-26
34171817-1	2021	An electrochemiluminescence sensor was proposed for detection of prostate-specific antigen (PSA) based on dual-amplification strategy of ferrocenecarboxylic acid@MgAl layered double hydroxides (Fc@MgAl-LDH) and NH2-MIL-101(Fe).	Iron	223-225	kallikrein related peptidase 3	Homo sapiens	65-90
29021231-1	2017	Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males.	Iron	165-169	hemojuvelin BMP co-receptor	Mus musculus	73-84
34644351-0	2021	Hepcidin induces intestinal calcium uptake while suppressing iron uptake in Caco-2 cells.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
29021231-1	2017	Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males.	Iron	165-169	hemojuvelin BMP co-receptor	Mus musculus	86-89
29021231-1	2017	Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males.	Iron	196-200	hemojuvelin BMP co-receptor	Mus musculus	73-84
29021231-1	2017	Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males.	Iron	196-200	hemojuvelin BMP co-receptor	Mus musculus	86-89
34644351-5	2021	To investigate the potential mechanism, effects of hepcidin on the expression of iron and calcium transporter and transport-associated protein in Caco-2 cells were also determined.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	51-59
29955721-3	2018	Less is known about the relationship between micronutrients, including iron, and SCD activity.	Iron	71-75	stearoyl-CoA desaturase	Homo sapiens	81-84
34644351-6	2021	Our results showed that intestinal cell iron uptake was significantly increased by ascorbic acid together with ferric ammonium citrate (FAC), but this phenomenon was suppressed by hepcidin.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	180-188
34644351-8	2021	While hepcidin significantly suppressed the expression of iron transporter, it had no effect on calcium transporter expression.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	6-14
34644351-12	2021	Taken together, our results showed that hepcidin could effectively and concurrently induce intestinal cell calcium uptake while reducing intestinal cell iron uptake under physiological and iron uptake stimulation conditions, suggesting its therapeutic potential for inactive calcium absorption, particularly in thalassemic patients or patients who did not adequately respond to 1,25(OH)2D3.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	40-48
29017326-0	2017	Mechanism of Nakamura"s Bisphosphine-Iron-Catalyzed Asymmetric C(sp2)-C(sp3) Cross-Coupling Reaction: The Role of Spin in Controlling Arylation Pathways.	Iron	37-41	spindlin 1	Homo sapiens	114-118
34644351-12	2021	Taken together, our results showed that hepcidin could effectively and concurrently induce intestinal cell calcium uptake while reducing intestinal cell iron uptake under physiological and iron uptake stimulation conditions, suggesting its therapeutic potential for inactive calcium absorption, particularly in thalassemic patients or patients who did not adequately respond to 1,25(OH)2D3.	Iron	189-193	hepcidin antimicrobial peptide	Homo sapiens	40-48
34644442-2	2022	In search for the best conditions to accumulate and store bioavailable iron, we made use of a double mutant null for the monothiol glutaredoxins GRX3 and GRX4.	Iron	71-75	glutaredoxin 3	Homo sapiens	145-149
34644442-2	2022	In search for the best conditions to accumulate and store bioavailable iron, we made use of a double mutant null for the monothiol glutaredoxins GRX3 and GRX4.	Iron	71-75	glutaredoxin 3	Homo sapiens	154-158
28864813-1	2017	The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	56-64
28864813-1	2017	The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12.	Iron	117-121	hepcidin antimicrobial peptide	Mus musculus	56-64
34644442-3	2022	The strain grx3grx4 accumulates high iron concentrations in the cytoplasm, making the metal easily available for ferritin chelation.	Iron	37-41	glutaredoxin 3	Homo sapiens	11-19
34553919-1	2021	Herein, a versatile ECL biosensor was fabricated for ultrasensitive detection of microRNA-21 (miRNA-21) from cancer cells based on a novel H2O2-free electrochemiluminescence (ECL) system (luminol/dissolved oxygen/Fe@Fe2O3 nanowires).	Iron	213-215	microRNA 21	Homo sapiens	81-92
28935588-4	2017	A decrease in the level of TF and an increase in the level of FTL also occurred in methapyrilene-treated differentiated HepaRG cells, indicating the existence of interspecies and in vitro-in vivo similarities in the disturbance of cellular iron homeostasis upon liver injury.	Iron	240-244	ferritin light chain	Homo sapiens	62-65
34553919-1	2021	Herein, a versatile ECL biosensor was fabricated for ultrasensitive detection of microRNA-21 (miRNA-21) from cancer cells based on a novel H2O2-free electrochemiluminescence (ECL) system (luminol/dissolved oxygen/Fe@Fe2O3 nanowires).	Iron	213-215	microRNA 21	Homo sapiens	94-102
34553919-6	2021	As expected, on account of the superb activation performance of Fe@Fe2O3 nanowires and the outstanding amplification efficiency of the SDR-SDA strategy, the fabricated ECL biosensor realized ultrasensitive detection of miRNA-21 with a detection limit down to 52.5 aM.	Iron	64-66	microRNA 21	Homo sapiens	219-227
34258619-0	2021	Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	0-8
29148959-4	2017	GGT is thought to induce oxidative stress in the artery wall in the presence of free iron and is likely an indicator of a depleted supply of glutathione, especially in the liver, which can lead to a cascade of problems related to increased oxidative stress.	Iron	85-89	inactive glutathione hydrolase 2	Homo sapiens	0-3
28803783-11	2017	Our work suggests a functional difference between IBA57 and other proteins involved in maturation of [Fe-S] proteins.	Iron	102-106	iron-sulfur cluster assembly factor IBA57	Homo sapiens	50-55
28867595-2	2017	The principal target(s) of copper toxicity have not been pinpointed, but one key effect is impaired supply of iron-sulfur (FeS) clusters to the essential protein Rli1 (ABCE1).	Iron	123-126	ATP binding cassette subfamily E member 1	Homo sapiens	162-166
28867595-2	2017	The principal target(s) of copper toxicity have not been pinpointed, but one key effect is impaired supply of iron-sulfur (FeS) clusters to the essential protein Rli1 (ABCE1).	Iron	123-126	ATP binding cassette subfamily E member 1	Homo sapiens	168-173
34258619-2	2021	Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are known to cause iron overload and hemochromatosis.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	55-63
34258619-2	2021	Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are known to cause iron overload and hemochromatosis.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	55-63
34258619-3	2021	OBJECTIVES: The objective of this study was to determine whether common genetic variation in the hepcidin-regulating iron metabolism pathway is associated with PDAC.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	97-105
29038603-2	2017	From SP-STM images using Fe-coated W tips magnetized to the out-of-plane and [001] directions, we found that both Mn mono- and double-layers exhibit cycloidal rotation whose spins rotate in the planes normal to the propagating directions.	Iron	25-27	sulfotransferase family 1A member 3	Homo sapiens	8-11
34258619-8	2021	CONCLUSIONS: Our results support that genetic susceptibility related to the hepcidin-regulating gene pathway is associated with PDAC risk and suggest a potential role of iron metabolism in pancreatic carcinogenesis.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	76-84
34529409-1	2021	Tetranuclear Cp4M4(CO)4 clusters have been synthesized for iron and vanadium but not for the intermediate first-row transition metals manganese and chromium.	Iron	59-63	complement C4A (Rodgers blood group)	Homo sapiens	13-23
28583802-2	2017	A matched sufficient pre- and post-natal diet, which has high carbohydrate and normal iron content (LF12), increased inflammatory gene expression markers in adult livers that were suppressed by GVAD and Cyp1b1 deletion.	Iron	86-90	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	203-209
28583802-3	2017	At birth on the LF12 diet, Cyp1b1 deletion and GVAD each suppress liver expression of the iron suppressor, hepcidin (Hepc), while increasing stellate cell activation markers and suppressing post-natal increases in lipogenesis.	Iron	90-94	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	27-33
28583802-3	2017	At birth on the LF12 diet, Cyp1b1 deletion and GVAD each suppress liver expression of the iron suppressor, hepcidin (Hepc), while increasing stellate cell activation markers and suppressing post-natal increases in lipogenesis.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	107-115
28583802-3	2017	At birth on the LF12 diet, Cyp1b1 deletion and GVAD each suppress liver expression of the iron suppressor, hepcidin (Hepc), while increasing stellate cell activation markers and suppressing post-natal increases in lipogenesis.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	117-121
28583802-4	2017	Hepc was less suppressed in Cyp1b1-/- pups with a standard breeder diet, but was restored by iron supplementation of the LF12 diet.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	0-4
34547129-5	2021	Consistently, the effect of IRG1 deficiency on IL-1beta secretion and iron metabolism was confirmed in IRG1 knockout THP-1 cell lines.	Iron	70-74	aconitate decarboxylase 1	Homo sapiens	28-32
34547129-5	2021	Consistently, the effect of IRG1 deficiency on IL-1beta secretion and iron metabolism was confirmed in IRG1 knockout THP-1 cell lines.	Iron	70-74	aconitate decarboxylase 1	Homo sapiens	103-107
28609726-0	2017	Removal of tetracycline from aqueous solution by MCM-41-zeolite A loaded nano zero valent iron: Synthesis, characteristic, adsorption performance and mechanism.	Iron	90-94	methylmalonyl-CoA mutase	Homo sapiens	49-52
28609726-1	2017	In this study, nano zero valent iron (NZVI) modified MCM-41-zeolite A (Fe-MCM-41-A) composite as a novel adsorbent was prepared by precipitation method and applied for tetracycline (TC) removal from aqueous solution.	Iron	32-36	methylmalonyl-CoA mutase	Homo sapiens	53-56
34547129-9	2021	Our results demonstrate the counteracting effects of overexpression of mitochondrial aconitase (ACO2, a tricarboxylic acid cycle enzyme) or cytosolic aconitase (ACO1, an iron regulatory protein) on IL-1beta secretion and altered iron metabolism.	Iron	170-174	interleukin 1 alpha	Homo sapiens	198-206
28609726-1	2017	In this study, nano zero valent iron (NZVI) modified MCM-41-zeolite A (Fe-MCM-41-A) composite as a novel adsorbent was prepared by precipitation method and applied for tetracycline (TC) removal from aqueous solution.	Iron	32-36	methylmalonyl-CoA mutase	Homo sapiens	74-77
34547129-11	2021	Our findings indicate that the immunoregulatory functions of IRG1 and itaconate in macrophages are stressful Fe-S cluster of aconitases disrupting and iron metabolism rebalancing.	Iron	151-155	aconitate decarboxylase 1	Homo sapiens	61-65
28760824-0	2017	The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast.	Iron	107-111	Ccc1p	Saccharomyces cerevisiae S288C	126-130
28760824-2	2017	One key protein involved in vacuolar iron storage is the iron importer Ccc1, which facilitates iron entry into the vacuole.	Iron	37-41	Ccc1p	Saccharomyces cerevisiae S288C	71-75
34274368-0	2021	Reply to "Ceruloplasmin Variants Might Have Different Effects in Different Iron Overload Disorders".	Iron	75-79	ceruloplasmin	Homo sapiens	10-23
28760824-2	2017	One key protein involved in vacuolar iron storage is the iron importer Ccc1, which facilitates iron entry into the vacuole.	Iron	57-61	Ccc1p	Saccharomyces cerevisiae S288C	71-75
28760824-2	2017	One key protein involved in vacuolar iron storage is the iron importer Ccc1, which facilitates iron entry into the vacuole.	Iron	57-61	Ccc1p	Saccharomyces cerevisiae S288C	71-75
28760824-3	2017	Transcription of the CCC1 gene is largely regulated by the binding of iron-sulfur clusters to the activator domain of the transcriptional activator Yap5.	Iron	70-74	Ccc1p	Saccharomyces cerevisiae S288C	21-25
28760824-4	2017	Additional evidence, however, suggests that Yap5-independent transcriptional activation of CCC1 also contributes to iron resistance.	Iron	116-120	Ccc1p	Saccharomyces cerevisiae S288C	91-95
28760824-8	2017	Deletion of all three alternative partners of Snf1 encoded by SIT1, SIT2, and GAL83 decreased both CCC1 transcription and iron resistance.	Iron	122-126	Gal83p	Saccharomyces cerevisiae S288C	78-83
34636961-12	2021	If so, hepcidin, a regulator of iron absorption and its distribution into tissues, is suggested to play a major role in the pathogenesis of iron dyshomeostasis and risk for initiating and progressing alpha-synuclein pathology.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	7-15
28767230-1	2017	Product release is the rate-determining step in the arene syn-dihydroxylation reaction taking place at Rieske oxygenase enzymes and is regarded as a difficult problem to be resolved in the design of iron catalysts for olefin syn-dihydroxylation with potential utility in organic synthesis.	Iron	199-203	synemin	Homo sapiens	58-61
28767230-1	2017	Product release is the rate-determining step in the arene syn-dihydroxylation reaction taking place at Rieske oxygenase enzymes and is regarded as a difficult problem to be resolved in the design of iron catalysts for olefin syn-dihydroxylation with potential utility in organic synthesis.	Iron	199-203	synemin	Homo sapiens	225-228
28913435-0	2017	IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy.	Iron	25-29	iron-sulfur cluster assembly factor IBA57	Homo sapiens	0-5
28825299-2	2017	We used this method to obtain the five- and six-coordinate complexes [Fe(TPP)(NO)]+ (TPP2- = tetraphenylporphyrin dianion) and [Fe(TPP)(NO)(MI)]+ (MI = 1-methylimidazole) and demonstrate that these complexes are stable in solution in the absence of excess NO gas.	Iron	70-72	tripeptidyl peptidase 2	Homo sapiens	85-89
34550543-0	2021	Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV-1 Tat oligomerization and beta-catenin expression.	Iron	13-17	catenin beta 1	Homo sapiens	111-123
28673786-7	2017	Moreover, the results showed a network in which diurnal variations in systemic iron levels were tightly regulated by hepcidin and Tf/TfR via DCYTB and DMT1.	Iron	79-83	hepcidin antimicrobial peptide	Sus scrofa	117-125
34474395-1	2021	Ceruloplasmin (Cp) is a ferroxidase enzyme that is essential for cell iron efflux and has been postulated to have a neuroprotective role.	Iron	70-74	ceruloplasmin	Mus musculus	0-13
29024968-0	2017	Iron suppresses ovarian granulosa cell proliferation and arrests cell cycle through regulating p38 mitogen-activated protein kinase/p53/p21 pathway.	Iron	0-4	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	136-139
34474395-9	2021	Together, our data indicate that Cp ferroxidase activity is essential for OLs and SCs maturation during early postnatal development and iron homeostasis in matured myelinating cells.	Iron	136-140	ceruloplasmin	Mus musculus	36-47
34587896-1	2021	BACKGROUND: Cisd1 and Cisd2 proteins share very similar structures with an N-terminal membrane-anchoring domain and a C-terminal cytosolic domain containing an iron-cluster binding domain and ending with a C-terminal KKxx sequence.	Iron	160-164	CDGSH iron sulfur domain 1	Homo sapiens	12-17
28576871-0	2017	STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.	Iron	68-72	STEAP4 metalloreductase	Homo sapiens	0-6
28576871-2	2017	Six transmembrane epithelial antigen of the prostate 4 (STEAP4), a metalloreductase involved in iron and copper homeostasis, is thought to play a potentially important role in the cellular response to inflammatory stress.	Iron	96-100	STEAP4 metalloreductase	Homo sapiens	56-62
28576871-6	2017	These cells struggle to maintain their function in iron or copper overloaded states, presumably due to increased oxidative stress, suggesting STEAP4"s role in metal homeostasis is critical to the maintenance of cellular homeostasis in general, and in preventing the onset of metabolic disease.	Iron	51-55	STEAP4 metalloreductase	Homo sapiens	142-148
28576871-8	2017	We then examine how STEAP4"s role as a regulator of cellular iron and copper may relate to type 2 diabetes.	Iron	61-65	STEAP4 metalloreductase	Homo sapiens	20-26
34685529-0	2021	New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-kappaB Signaling-Mediated Inflammatory Responses in Human Monocytes.	Iron	38-42	toll like receptor 4	Homo sapiens	62-66
27578012-6	2017	Our findings suggest that the age-dependent increase in brain iron may be partly due to the age-induced increase in DMT1 expression, rather than TfR1 and Fpn1 expression, and also imply that the increased brain iron is associated with expression of the pathological hallmarks of AD and PD.	Iron	62-66	RoBo-1	Rattus norvegicus	116-120
34641326-4	2021	Our laboratory has previously examined this hypothesis in tumor cells and has demonstrated that dinitrosyl-dithiol-iron-complexes are transported and stored by multi-drug resistance-related protein 1 and glutathione-S-transferase P1.	Iron	115-119	glutathione S-transferase pi 1	Homo sapiens	204-232
28864822-1	2017	Hepcidin regulates systemic iron homeostasis.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	0-8
28864822-8	2017	We conclude that suppression of hepcidin expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	32-40
28864822-8	2017	We conclude that suppression of hepcidin expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	108-116
28864822-8	2017	We conclude that suppression of hepcidin expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling.	Iron	172-176	hepcidin antimicrobial peptide	Mus musculus	32-40
28864822-8	2017	We conclude that suppression of hepcidin expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling.	Iron	172-176	hepcidin antimicrobial peptide	Mus musculus	108-116
28864822-8	2017	We conclude that suppression of hepcidin expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling.	Iron	172-176	hepcidin antimicrobial peptide	Mus musculus	32-40
28864822-8	2017	We conclude that suppression of hepcidin expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling.	Iron	172-176	hepcidin antimicrobial peptide	Mus musculus	108-116
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	44-48	glutathione S-transferase pi 1	Homo sapiens	62-90
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	44-48	glutathione S-transferase pi 1	Homo sapiens	152-180
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	227-231	glutathione S-transferase pi 1	Homo sapiens	62-90
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	227-231	glutathione S-transferase pi 1	Homo sapiens	152-180
34630348-2	2021	Moraxella catarrhalis resides exclusively on the mucosal surfaces of the upper respiratory tract of humans and is capable of directly acquiring iron for growth from the host glycoproteins human transferrin (hTf) and human lactoferrin (hLf).	Iron	144-148	coagulation factor III, tissue factor	Homo sapiens	207-210
28499955-11	2017	Taken together, these findings suggest that HNK, which can be excluded by overexpression of Pdr5, functions in multiple cellular processes in S. cerevisiae, particularly in inducing iron starvation to inhibit cell growth.	Iron	182-186	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	92-96
28628361-0	2017	Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.	Iron	35-39	lipocalin 2	Homo sapiens	0-11
28628361-2	2017	As a bacteriostatic factor, Lcn2 obstructs the siderophore iron-acquiring strategy of bacteria and thus inhibits bacterial growth.	Iron	59-63	lipocalin 2	Homo sapiens	28-32
28628361-3	2017	As part of host nutritional immunity, Lcn2 facilitates systemic, cellular, and mucosal hypoferremia during inflammation, in addition to stabilizing the siderophore-bound labile iron pool.	Iron	177-181	lipocalin 2	Homo sapiens	38-42
28628361-4	2017	In this review, we summarize recent advances in understanding the interaction between Lcn2 and iron, and its effects in various inflammatory diseases.	Iron	95-99	lipocalin 2	Homo sapiens	86-90
28628361-6	2017	Further animal and clinical studies are necessary to unveil the multifaceted roles of Lcn2 in iron dysregulation during inflammation and to explore its therapeutic potential for treating inflammatory diseases.	Iron	94-98	lipocalin 2	Homo sapiens	86-90
34630348-2	2021	Moraxella catarrhalis resides exclusively on the mucosal surfaces of the upper respiratory tract of humans and is capable of directly acquiring iron for growth from the host glycoproteins human transferrin (hTf) and human lactoferrin (hLf).	Iron	144-148	HLF transcription factor, PAR bZIP family member	Homo sapiens	235-238
34630348-3	2021	The iron-bound form of these glycoproteins is initially captured by the surface lipoproteins Tf or Lf binding protein B (TbpB or LbpB) and delivered to the integral outer membrane TonB-dependent transport (TBDT) proteins, Tf binding protein A (TbpA) or Lf binding protein A (LbpA).	Iron	4-8	coagulation factor III, tissue factor	Homo sapiens	93-95
28715185-5	2017	In the fast rebinding hTDO conformation, there is facile ligand access to the heme iron, but it is greatly hindered in the slowly rebinding conformation.	Iron	83-87	tryptophan 2,3-dioxygenase	Homo sapiens	22-26
34630348-4	2021	The extraction of iron involves conformational changes in Lf and Tf to facilitate iron removal followed by its transport across the outer membrane by a well characterized process for TBDTs.	Iron	18-22	HLF transcription factor, PAR bZIP family member	Homo sapiens	58-60
34630348-4	2021	The extraction of iron involves conformational changes in Lf and Tf to facilitate iron removal followed by its transport across the outer membrane by a well characterized process for TBDTs.	Iron	18-22	coagulation factor III, tissue factor	Homo sapiens	65-67
28389699-7	2017	This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause.	Iron	145-149	hephaestin	Homo sapiens	123-127
34630348-4	2021	The extraction of iron involves conformational changes in Lf and Tf to facilitate iron removal followed by its transport across the outer membrane by a well characterized process for TBDTs.	Iron	82-86	HLF transcription factor, PAR bZIP family member	Homo sapiens	58-60
34630348-4	2021	The extraction of iron involves conformational changes in Lf and Tf to facilitate iron removal followed by its transport across the outer membrane by a well characterized process for TBDTs.	Iron	82-86	coagulation factor III, tissue factor	Homo sapiens	65-67
34630348-9	2021	We propose that the indirect effect on iron transport from Tf and Lf by CopB could possibly be explained by the association of TBDTs at gaps in the peptidoglycan layer that may enhance the efficiency of the process.	Iron	39-43	coagulation factor III, tissue factor	Homo sapiens	59-61
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	94-96	zinc finger protein-like protein	Arabidopsis thaliana	35-41
34630348-9	2021	We propose that the indirect effect on iron transport from Tf and Lf by CopB could possibly be explained by the association of TBDTs at gaps in the peptidoglycan layer that may enhance the efficiency of the process.	Iron	39-43	HLF transcription factor, PAR bZIP family member	Homo sapiens	66-68
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	94-96	zinc finger protein-like protein	Arabidopsis thaliana	43-46
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	94-96	zinc finger protein-like protein	Arabidopsis thaliana	159-162
34538261-2	2021	For the first time, the hypothesis that iron overload in megaloblastic anemia may be related to ineffective erythropoiesis is explored by describing the kinetics of hepcidin, erythroferrone, and growth differentiation factor-15 levels in a patient diagnosed with megaloblastic anemia associated with iron overload.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	165-173
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	94-96	zinc finger protein-like protein	Arabidopsis thaliana	159-162
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	94-96	zinc finger protein-like protein	Arabidopsis thaliana	159-162
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	280-282	zinc finger protein-like protein	Arabidopsis thaliana	35-41
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	280-282	zinc finger protein-like protein	Arabidopsis thaliana	43-46
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	280-282	zinc finger protein-like protein	Arabidopsis thaliana	159-162
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	280-282	zinc finger protein-like protein	Arabidopsis thaliana	159-162
28620661-3	2017	The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.	Iron	280-282	zinc finger protein-like protein	Arabidopsis thaliana	159-162
28620661-6	2017	Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions.	Iron	91-93	zinc finger protein-like protein	Arabidopsis thaliana	70-73
28620661-6	2017	Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions.	Iron	148-150	zinc finger protein-like protein	Arabidopsis thaliana	70-73
28620661-6	2017	Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions.	Iron	148-150	zinc finger protein-like protein	Arabidopsis thaliana	70-73
28620661-6	2017	Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions.	Iron	148-150	zinc finger protein-like protein	Arabidopsis thaliana	70-73
28620661-6	2017	Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions.	Iron	148-150	zinc finger protein-like protein	Arabidopsis thaliana	70-73
34538261-2	2021	For the first time, the hypothesis that iron overload in megaloblastic anemia may be related to ineffective erythropoiesis is explored by describing the kinetics of hepcidin, erythroferrone, and growth differentiation factor-15 levels in a patient diagnosed with megaloblastic anemia associated with iron overload.	Iron	300-304	hepcidin antimicrobial peptide	Homo sapiens	165-173
34575569-4	2021	In addition to GEM, Deferasirox (DFX) was also loaded into drug carrier, M1Exo, in order to inhibit ribonucleotide reductase regulatory subunit M2 (RRM2) expression via depleting iron, and thus increase chemosensitivity of GEM.	Iron	179-183	ribonucleotide reductase regulatory subunit M2	Homo sapiens	148-152
28720890-3	2017	Cardiac iron levels increased progressively with age, which was exacerbated in Hfe-deficient mice.	Iron	8-12	homeostatic iron regulator	Mus musculus	79-82
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	17-21	iron-sulfur cluster assembly factor IBA57	Homo sapiens	233-238
28356563-1	2017	The iron-sulfur (Fe-S) cluster (ISC) biogenesis pathway is indispensable for many fundamental biological processes and pathogenic variations in genes encoding several components of the Fe-S biogenesis machinery, such as NFU1, BOLA3, IBA57 and ISCA2 are already implicated in causing four types of multiple mitochondrial dysfunctions syndromes (MMDS).	Iron	185-189	iron-sulfur cluster assembly factor IBA57	Homo sapiens	233-238
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	124-128	toll like receptor 4	Homo sapiens	13-17
28372951-4	2017	Compared with controls, allografts and recipient spleens derived from iron-overloaded recipients were characterized by a pronounced graft infiltration of CD4+ T cells (p &lt; 0.01), CD3-NKp46+ natural killer cells (p &lt; 0.05), and reduced frequencies of regulatory T cells (p &lt; 0.01).	Iron	70-74	CD4 antigen	Mus musculus	154-157
28372951-6	2017	Cardiac allograft survival was further tested under co-stimulation blockade (CTLA4-Ig) showing that naive grafts transplanted into iron-overloaded recipients illustrated restricted graft outcome compared with wild types (p = 0.0051), which was rescued after treatment with the iron chelator deferoxamine.	Iron	131-135	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	77-82
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	90-98
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	168-172	toll like receptor 4	Homo sapiens	13-17
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	90-98
34510284-1	2022	PURPOSE: Iron is usually administered in hemodialysis patients by parenteral route, as oral absorption is poor due to high hepcidin levels.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	123-131
28266714-3	2017	Hepcidin is a key regulator of systemic iron homeostasis.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	0-8
34498446-2	2021	The iron-regulatory hormone hepcidin is highly upregulated during malaria and controls the availability of iron, a critical nutrient for bacterial growth.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
28461400-5	2017	In mutant embryos lacking expression of VACUOLAR IRON TRANSPORTER1 (VIT1), MTP8 built up iron (Fe) hotspots in MTP8-expressing cells types, suggesting that MTP8 transports Fe in addition to Mn.	Iron	89-93	vacuolar iron transporter 1	Arabidopsis thaliana	40-66
34498446-2	2021	The iron-regulatory hormone hepcidin is highly upregulated during malaria and controls the availability of iron, a critical nutrient for bacterial growth.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	28-36
28461400-5	2017	In mutant embryos lacking expression of VACUOLAR IRON TRANSPORTER1 (VIT1), MTP8 built up iron (Fe) hotspots in MTP8-expressing cells types, suggesting that MTP8 transports Fe in addition to Mn.	Iron	95-97	vacuolar iron transporter 1	Arabidopsis thaliana	40-66
28461400-5	2017	In mutant embryos lacking expression of VACUOLAR IRON TRANSPORTER1 (VIT1), MTP8 built up iron (Fe) hotspots in MTP8-expressing cells types, suggesting that MTP8 transports Fe in addition to Mn.	Iron	172-174	vacuolar iron transporter 1	Arabidopsis thaliana	40-66
34323351-5	2021	Although endophilin A2-mediated endocytosis is dispensable for antigen presentation, it is selectively required for metabolic support of B-cell proliferation, in part through regulation of iron uptake.	Iron	189-193	SH3-domain GRB2-like 1	Mus musculus	9-22
28461400-5	2017	In mutant embryos lacking expression of VACUOLAR IRON TRANSPORTER1 (VIT1), MTP8 built up iron (Fe) hotspots in MTP8-expressing cells types, suggesting that MTP8 transports Fe in addition to Mn.	Iron	172-174	vacuolar iron transporter 1	Arabidopsis thaliana	68-72
28660875-0	2017	Imaging the real space structure of the spin fluctuations in an iron-based superconductor.	Iron	64-68	spindlin 1	Homo sapiens	40-44
28660875-1	2017	Spin fluctuations are a leading candidate for the pairing mechanism in high temperature superconductors, supported by the common appearance of a distinct resonance in the spin susceptibility across the cuprates, iron-based superconductors and many heavy fermion materials.	Iron	212-216	spindlin 1	Homo sapiens	0-4
28660875-1	2017	Spin fluctuations are a leading candidate for the pairing mechanism in high temperature superconductors, supported by the common appearance of a distinct resonance in the spin susceptibility across the cuprates, iron-based superconductors and many heavy fermion materials.	Iron	212-216	spindlin 1	Homo sapiens	171-175
34118782-4	2021	Compared to other electron acceptors used in anaerobic respiration (e.g. N, S, Fe, Mn, and As), Se is one of the few elements whose end product is solid.	Iron	79-81	squalene epoxidase	Homo sapiens	96-98
28646124-0	2017	Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.	Iron	91-103	lysine demethylase 3A	Homo sapiens	40-46
34427071-11	2021	Furthermore, we found that ROS levels and DMT1 expression were elevated in TG905 cells treated with temozolomide and were accompanied by a decrease in the expression of glutathione peroxidase 4, indicating an iron-dependent cell death, ferroptosis.	Iron	209-213	glutathione peroxidase 4	Homo sapiens	169-193
28548666-3	2017	We previously showed that oligomerization is a mechanism by which yeast frataxin (Yfh1) can promote assembly of the core machinery for Fe-S cluster synthesis both in vitro and in cells, in such a manner that the scaffold protein, Isu1, can bind to Yfh1 independent of the presence of the cysteine desulfurase, Nfs1.	Iron	135-139	ferroxidase	Saccharomyces cerevisiae S288C	82-86
28548666-6	2017	However, upon binding to oligomeric Yfh1, both forms take on a similar symmetrical trimeric configuration that places the Fe-S cluster coordinating residues of Isu1 in close proximity of iron-binding residues of Yfh1.	Iron	122-124	ferroxidase	Saccharomyces cerevisiae S288C	36-40
28548666-6	2017	However, upon binding to oligomeric Yfh1, both forms take on a similar symmetrical trimeric configuration that places the Fe-S cluster coordinating residues of Isu1 in close proximity of iron-binding residues of Yfh1.	Iron	122-124	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	160-164
28548666-6	2017	However, upon binding to oligomeric Yfh1, both forms take on a similar symmetrical trimeric configuration that places the Fe-S cluster coordinating residues of Isu1 in close proximity of iron-binding residues of Yfh1.	Iron	187-191	ferroxidase	Saccharomyces cerevisiae S288C	36-40
28548666-6	2017	However, upon binding to oligomeric Yfh1, both forms take on a similar symmetrical trimeric configuration that places the Fe-S cluster coordinating residues of Isu1 in close proximity of iron-binding residues of Yfh1.	Iron	187-191	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	160-164
28548666-8	2017	Moreover, distinct structural features suggest that in physiological conditions the zinc-regulated abundance of monomeric vs. oligomeric Isu1 yields [Yfh1] [Isu1] complexes with different Isu1 configurations that afford unique functional properties for Fe-S cluster assembly and delivery.	Iron	253-255	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	137-141
28548666-8	2017	Moreover, distinct structural features suggest that in physiological conditions the zinc-regulated abundance of monomeric vs. oligomeric Isu1 yields [Yfh1] [Isu1] complexes with different Isu1 configurations that afford unique functional properties for Fe-S cluster assembly and delivery.	Iron	253-255	ferroxidase	Saccharomyces cerevisiae S288C	150-154
28548666-8	2017	Moreover, distinct structural features suggest that in physiological conditions the zinc-regulated abundance of monomeric vs. oligomeric Isu1 yields [Yfh1] [Isu1] complexes with different Isu1 configurations that afford unique functional properties for Fe-S cluster assembly and delivery.	Iron	253-255	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	157-161
34146907-2	2021	It is unclear whether the NMD pathway is involved in regulating ferroptosis, which is a type of iron-dependent cell death mainly caused by the inhibition of the antioxidant SLC7A11-GPX4 axis.	Iron	96-100	solute carrier family 7 member 11	Homo sapiens	173-180
28548666-8	2017	Moreover, distinct structural features suggest that in physiological conditions the zinc-regulated abundance of monomeric vs. oligomeric Isu1 yields [Yfh1] [Isu1] complexes with different Isu1 configurations that afford unique functional properties for Fe-S cluster assembly and delivery.	Iron	253-255	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	157-161
29910405-8	2017	The low intake of energy, calcium, and iron noted within this study could have negative effects on performance and short- and long-term health in female dragon boat athletes.	Iron	39-43	ataxin 1 like	Homo sapiens	160-164
34573286-2	2021	Iron homeostasis disorders develop as a result of HFE gene mutations, which are associated with hepcidin arthropathy or osteoporosis and may cause permanent disability in HH patients despite a properly conducted treatment with phlebotomies.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	96-104
28747430-4	2017	We also found that FDXR was necessary for mitochondrial iron homeostasis and proper expression of several master regulators of iron metabolism, including iron regulatory protein 2 (IRP2).	Iron	127-131	iron responsive element binding protein 2	Mus musculus	154-179
28747430-4	2017	We also found that FDXR was necessary for mitochondrial iron homeostasis and proper expression of several master regulators of iron metabolism, including iron regulatory protein 2 (IRP2).	Iron	127-131	iron responsive element binding protein 2	Mus musculus	181-185
34272312-10	2021	We show that Schwann cells (SCs) are a likely source as they express the molecular machinery to import iron (transferrin receptor 1), and to export iron (ferroportin and ceruloplasmin (Cp)) to the axonal compartment at the nodes of Ranvier (NR) and Schmidt-Lanterman incisures (SLIs).	Iron	148-152	ceruloplasmin	Mus musculus	170-183
27925282-7	2017	Further studies found that the iron regulatory protein 2 (IRP2) played a dominant regulatory role in the changes of iron hemostasis, whereas iron regulatory protein 1 (IRP1) mainly acted as cis-aconitase.	Iron	31-35	iron responsive element binding protein 2	Rattus norvegicus	58-62
34426578-5	2021	Cellular studies indicate that both Dpep1 and Chmp1a are important regulators of a single pathway, ferroptosis and lead to kidney disease development via altering cellular iron trafficking.	Iron	172-176	dipeptidase 1	Mus musculus	36-41
28365006-3	2017	In this light, we screened the C19orf12 neurodegeneration with brain iron accumulation (NBIA) causing gene and the C9orf72 intronic expansion mutation that is cause of amyotrophic lateral sclerosis in 186 Iranian Parkinson"s disease (PD) patients.	Iron	69-73	chromosome 19 open reading frame 12	Homo sapiens	31-39
34415720-0	2021	MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy.	Iron	46-50	C-C motif chemokine ligand 2	Homo sapiens	0-5
28365006-5	2017	The study was justified because mutations in C19orf12 had previously been shown to be common in Iranian neurodegeneration with brain iron accumulation patients and all the patients with mutations in this gene had exhibited Parkinsonism features.	Iron	133-137	chromosome 19 open reading frame 12	Homo sapiens	45-53
28347615-1	2017	INTRODUCTION: Mutations in the C19orf12 gene cause mitochondrial membrane protein associated neurodegeneration (MPAN), an autosomal recessive form of neurodegeneration with brain iron accumulation (NBIA).	Iron	179-183	chromosome 19 open reading frame 12	Homo sapiens	31-39
34415720-0	2021	MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy.	Iron	46-50	C-C motif chemokine ligand 2	Homo sapiens	82-87
28259531-1	2017	Ferrous iron can be converted to ferric iron by oxidative stress which results in the formation of methemoglobin.	Iron	0-12	hemoglobin subunit gamma 2	Homo sapiens	99-112
34242792-0	2021	Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation.	Iron	130-134	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-30
34242792-6	2021	In summary, our study confirmed that APAP-induced IDO1 aggravated ALF by triggering excess oxidative and nitrative stress and iron accumulation in liver.	Iron	126-130	indoleamine 2,3-dioxygenase 1	Homo sapiens	50-54
28457138-3	2017	The rise in the spin-up conductivity up to the bias voltage of 0.4 V is dominated by a conductive lowest unoccupied molecular orbital, and this is accompanied by a slight increase in the magnetic moment of the Fe atom.	Iron	210-212	spindlin 1	Homo sapiens	16-20
34390438-1	2022	PURPOSE: Previous studies reported that the long-acting erythropoiesis-stimulating agent (ESA) significantly suppresses the expression of hepcidin, which regulates iron availability.	Iron	164-168	hepcidin antimicrobial peptide	Homo sapiens	138-146
28475601-1	2017	A recent study demonstrated the association between inflammation, iron metabolism and fibroblast growth factor (FGF) 23.	Iron	66-70	fibroblast growth factor 23	Homo sapiens	86-119
28475601-2	2017	The present clinical study aimed to assess associations between anemia, iron metabolism and FGF23 in hemodialysis (HD) patients.	Iron	72-76	fibroblast growth factor 23	Homo sapiens	92-97
28475601-11	2017	Doses of intravenous iron supplementation were significantly increased in the higher i-FGF23 tertile in multivariate models.	Iron	21-25	fibroblast growth factor 23	Homo sapiens	87-92
28475601-12	2017	In conclusion, high i-FGF23 levels may be associated with prolongation of low levels of ferritin, resulting in increased usages of iron supplementation in HD patients.	Iron	131-135	fibroblast growth factor 23	Homo sapiens	22-27
34436298-7	2021	These genes were previously associated with ferroptosis, a programmed cell death triggered by iron-dependent lipid peroxidation, confirmed at the protein level by the down-regulation of GPX4, a key regulator of ferroptosis, and the up-regulation of NCOA4, involved in iron homeostasis.	Iron	94-98	glutathione peroxidase 4	Homo sapiens	186-190
34286752-1	2021	A cocktail (1 + 2) dual-fluorescent probe system was developed to realize the real-time visualization of dynamic iron state changes between Fe2+ and Fe3+ at the cellular level and in multicellular organisms, providing insights into the effect of DMT1 and ferroportin on iron regulation.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	246-250
28212898-0	2017	Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study.	Iron	10-14	fibroblast growth factor 23	Homo sapiens	52-57
28212898-0	2017	Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study.	Iron	10-14	MROS	Homo sapiens	86-90
28212898-3	2017	Serum iron (Fe) has been suggested as a regulator of FGF23 homeostasis.	Iron	6-10	fibroblast growth factor 23	Homo sapiens	53-58
28212898-3	2017	Serum iron (Fe) has been suggested as a regulator of FGF23 homeostasis.	Iron	12-14	fibroblast growth factor 23	Homo sapiens	53-58
28212898-4	2017	OBJECTIVE: To determine whether Fe and iron status are determinants of the levels of intact FGF23 (iFGF23) in elderly men.	Iron	32-34	fibroblast growth factor 23	Homo sapiens	92-97
34286752-1	2021	A cocktail (1 + 2) dual-fluorescent probe system was developed to realize the real-time visualization of dynamic iron state changes between Fe2+ and Fe3+ at the cellular level and in multicellular organisms, providing insights into the effect of DMT1 and ferroportin on iron regulation.	Iron	270-274	solute carrier family 11 member 2	Homo sapiens	246-250
34441564-8	2021	RNA-seq and signaling pathway analyses showed that iron overload caused ferroptosis in the liver of mice with a decrease in GPX4 expression and an increase in Ptgs2 expression, resulting in a high level of lipid peroxidation.	Iron	51-55	glutathione peroxidase 4	Mus musculus	124-128
28282554-1	2017	Erythroferrone (ERFE) and TMPRSS6 are important proteins in the regulation of iron metabolism.	Iron	78-82	erythroferrone	Rattus norvegicus	16-20
28282554-7	2017	Fam132b expression in the spleen was increased both by EPO and iron plus EPO treatments; these treatments also significantly induced splenic Fam132a expression.	Iron	63-67	erythroferrone	Rattus norvegicus	0-7
28282554-8	2017	ERFE protein content in the spleen was increased both by EPO and iron plus EPO to a similar extent.	Iron	65-69	erythroferrone	Rattus norvegicus	0-4
34280433-7	2021	Lastly, CLPX is required for iron utilization for hemoglobin synthesis during erythroid differentiation.	Iron	29-33	caseinolytic mitochondrial matrix peptidase chaperone subunit X	Homo sapiens	8-12
28290237-12	2017	TPO, the enzyme responsible for the production of thyroid hormones, is a heme (iron-containing) enzyme which becomes active at the apical surface of thyrocytes only after binding heme.	Iron	79-83	thyroid peroxidase	Homo sapiens	0-3
34280433-9	2021	Our studies reveal that CLPX mutations may cause anemia and porphyria via dysregulation of ALAS, FECH and PPOX activities, as well as of iron metabolism.	Iron	137-141	caseinolytic mitochondrial matrix peptidase chaperone subunit X	Homo sapiens	24-28
34360940-3	2021	Heme oxygenase-1 (HO-1) has evolved to promptly attend to such injurious potential by facilitating degradation of heme into equimolar amounts of carbon monoxide, iron, and biliverdin.	Iron	162-166	heme oxygenase 1	Homo sapiens	0-16
28449022-0	2017	"The iron is hot" for alcohol-related policy changes in New Zealand.	Iron	5-9	alcohol dehydrogenase iron containing 1	Homo sapiens	13-17
34360940-3	2021	Heme oxygenase-1 (HO-1) has evolved to promptly attend to such injurious potential by facilitating degradation of heme into equimolar amounts of carbon monoxide, iron, and biliverdin.	Iron	162-166	heme oxygenase 1	Homo sapiens	18-22
34360993-1	2021	The ferroxidase ceruloplasmin (CP) plays a crucial role in iron homeostasis in vertebrates together with the iron exporter ferroportin.	Iron	59-63	ceruloplasmin	Homo sapiens	31-33
34321467-4	2021	Herein, we report a single-atomic-site ruthenium stabilized on defective nickel-iron layered double hydroxide nanosheets (Ru1/D-NiFe LDH).	Iron	80-84	Scm like with four mbt domains 1	Homo sapiens	122-125
28264906-4	2017	While a meningococcal NMB0419 mutant did not have altered epithelial adherence, in a transcriptome-wide comparison of the wild type and an NMB0419 mutant, a large proportion of genes differentially regulated in the mutant were involved in iron acquisition and metabolism.	Iron	239-243	transcriptional regulator	Neisseria meningitidis MC58	22-29
28264906-6	2017	An in vitro growth defect of the NMB0419 mutant under iron restriction was consistent with the downregulation of tbpAB and hmbR, while an intraepithelial replication defect was consistent with the downregulation of tonB, exbB, and exbD, based on a known phenotype of a meningococcal tonB mutant.	Iron	54-58	transcriptional regulator	Neisseria meningitidis MC58	33-40
28328227-8	2017	Thus, the transient absorption spectra of these model compounds reveal the involvement of multiple iron spin states in the electronic relaxation dynamics, which could be an alternative pathway to the ground state beside the vibrational cooling processes and associated with the inherent features of the heme b type.	Iron	99-103	spindlin 1	Homo sapiens	104-108
34283874-0	2021	CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB.	Iron	82-86	cystathionine beta-synthase	Mus musculus	0-3
27121697-11	2017	CONCLUSION: Iron chelation by oral deferiprone has a renoprotective effect in DN rats by relieving oxidative stress, inflammation, and fibrosis, which is related to the cytokines NF-kappaB, MCP-1, MMP-9, TIMP-1, COX-2, and nitrotyrosine.	Iron	12-16	matrix metallopeptidase 9	Rattus norvegicus	197-202
27121697-11	2017	CONCLUSION: Iron chelation by oral deferiprone has a renoprotective effect in DN rats by relieving oxidative stress, inflammation, and fibrosis, which is related to the cytokines NF-kappaB, MCP-1, MMP-9, TIMP-1, COX-2, and nitrotyrosine.	Iron	12-16	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	204-210
34283879-1	2021	Erythroferrone (ERFE), the erythroid regulator of iron metabolism, inhibits hepcidin to increase iron availability for erythropoiesis.	Iron	50-54	erythroferrone	Homo sapiens	0-14
28188131-7	2017	Our data support the hypothesis that the improvement of inflammatory anemia by MMB results from inhibition of ACVR1-mediated hepcidin expression in the liver, which leads to increased mobilization of sequestered iron from cellular stores and subsequent stimulation of erythropoiesis.	Iron	212-216	activin A receptor type 1	Homo sapiens	110-115
34283879-1	2021	Erythroferrone (ERFE), the erythroid regulator of iron metabolism, inhibits hepcidin to increase iron availability for erythropoiesis.	Iron	50-54	erythroferrone	Homo sapiens	16-20
34283879-1	2021	Erythroferrone (ERFE), the erythroid regulator of iron metabolism, inhibits hepcidin to increase iron availability for erythropoiesis.	Iron	97-101	erythroferrone	Homo sapiens	0-14
34283879-1	2021	Erythroferrone (ERFE), the erythroid regulator of iron metabolism, inhibits hepcidin to increase iron availability for erythropoiesis.	Iron	97-101	erythroferrone	Homo sapiens	16-20
28352667-0	2017	Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
34244852-2	2022	Elevated hepcidin accounts for a significant iron redistribution in CKD.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	9-17
28352667-3	2017	Hepcidin is the master regulator of extracellular iron availability in vertebrates, but its role in the context of host defense is undefined.	Iron	50-54	hepcidin antimicrobial peptide	Mus musculus	0-8
28352667-4	2017	We hypothesized that hepcidin-mediated depletion of extracellular iron during Gram-negative pneumonia protects the host by limiting dissemination of bacteria to the bloodstream.	Iron	66-70	hepcidin antimicrobial peptide	Mus musculus	21-29
28352667-5	2017	During experimental pneumonia, hepcidin was induced in the liver in an IL-6-dependent manner and mediated a rapid decline in plasma iron.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	31-39
28352667-9	2017	These data show hepcidin induction during pneumonia to be essential to preventing bacterial dissemination by limiting extracellular iron availability.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	16-24
34236052-8	2021	Importantly, pharmacologic inhibition of the inflammasome and IL-1beta pathways reduced cytokine levels and mortality and partly restored infection control in iron-treated ferritin-deficient mice.	Iron	159-163	interleukin 1 alpha	Mus musculus	62-70
28151426-3	2017	Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis.	Iron	18-22	transferrin	Mus musculus	0-11
28151426-3	2017	Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis.	Iron	90-94	transferrin	Mus musculus	0-11
34226519-7	2021	At biochemical level, we further identified that cADPR, the mainly hydrolytic product of CD38, was responsible for inducing the opening of TRPM2 iron channel leading to the influx of intracellular Ca2+ and then led to increasing levels of NRF2 while decreasing expression of KEAP1 in lung cancer cells.	Iron	145-149	CD38 molecule	Homo sapiens	89-93
28262877-5	2017	Spin-splitting and spin-degenerate bands are realized in Ti-, V-, Cr-, Mn-, Fe-, and Co- and Sc-, Ni-, Cu-, and Zn-adsorbed systems, respectively.	Iron	76-78	spindlin 1	Homo sapiens	0-4
28262877-5	2017	Spin-splitting and spin-degenerate bands are realized in Ti-, V-, Cr-, Mn-, Fe-, and Co- and Sc-, Ni-, Cu-, and Zn-adsorbed systems, respectively.	Iron	76-78	spindlin 1	Homo sapiens	19-23
34324404-2	2021	Suppressed hepcidin levels increase ferroportin-mediated iron transport in enterocytes, causing increased iron absorption and potentially iron overload.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	11-19
27936396-0	2017	GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes.	Iron	66-70	glyceronephosphate O-acyltransferase	Homo sapiens	0-5
27936396-1	2017	BACKGROUND: GNPAT p.D519G positivity is significantly increased in HFE p.C282Y homozygotes with markedly increased iron stores.	Iron	115-119	glyceronephosphate O-acyltransferase	Homo sapiens	12-17
34324404-2	2021	Suppressed hepcidin levels increase ferroportin-mediated iron transport in enterocytes, causing increased iron absorption and potentially iron overload.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	11-19
27936396-11	2017	CONCLUSIONS: GNPAT p.D519G is strongly associated with markedly increased iron stores in p.C282Y homozygotes after correction for age, iron-related variables, and alcohol consumption.	Iron	74-78	glyceronephosphate O-acyltransferase	Homo sapiens	13-18
34324404-2	2021	Suppressed hepcidin levels increase ferroportin-mediated iron transport in enterocytes, causing increased iron absorption and potentially iron overload.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	11-19
27936396-11	2017	CONCLUSIONS: GNPAT p.D519G is strongly associated with markedly increased iron stores in p.C282Y homozygotes after correction for age, iron-related variables, and alcohol consumption.	Iron	135-139	glyceronephosphate O-acyltransferase	Homo sapiens	13-18
34324404-3	2021	Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	4-12
34324404-3	2021	Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	4-12
34324404-4	2021	Modulating the hepcidin-ferroportin axis is an attractive strategy to improve ineffective erythropoiesis and limit the potential tissue damage resulting from iron overload.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	15-23
34389105-1	2021	Twenty years ago the discovery of hepcidin deeply changed our understanding of the regulation of systemic iron homeostasis.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	34-42
28093505-1	2017	Erythropoietic protoporphyria (EPP) is caused by deficiency of ferrochelatase (FECH), which incorporates iron into protoporphyrin IX (PPIX) to form heme.	Iron	105-109	ferrochelatase	Mus musculus	79-83
34389105-2	2021	It is now clear that hepcidin orchestrates systemic iron levels by controlling the amount of iron exported into the bloodstream through ferroportin.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	21-29
28125220-3	2017	Furthermore, we show the assignment of the spin state of the complexes based on the vibrational modes of a coordinated anion and compare reactivities of various iron(IV)-oxo complexes generated as dications or monocations (bearing an anionic ligand).	Iron	161-165	spindlin 1	Homo sapiens	43-47
34389105-2	2021	It is now clear that hepcidin orchestrates systemic iron levels by controlling the amount of iron exported into the bloodstream through ferroportin.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	21-29
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	ferritin light chain	Homo sapiens	340-360
28216608-8	2017	The multivariate statistical analysis indicated an iron-related 10-protein panel effective in separating non-cancerous from cancerous lesions including STAT5, STAT5_pY694, myeloid differentiation factor 88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL).	Iron	51-55	ferritin light chain	Homo sapiens	362-365
34389105-3	2021	Hepcidin expression is increased in situations where systemic iron levels should be reduced, such as in iron overload and infection.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
34389105-3	2021	Hepcidin expression is increased in situations where systemic iron levels should be reduced, such as in iron overload and infection.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	0-8
34389105-4	2021	Conversely, hepcidin is repressed during iron deficiency, hypoxia or expanded erythropoiesis, to increase systemic iron availability and sustain erythropoiesis.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	12-20
34389106-3	2021	In the last years great advances in the understanding of the mechanisms of this crosstalk have been achieved thanks to the discovery of 2 essential players: hepcidin, the master regulator of iron homeostasis, and erythroferrone, the long sought erythroid regulator.	Iron	191-195	hepcidin antimicrobial peptide	Homo sapiens	157-165
27847325-9	2017	Here, we provide compelling evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots.	Iron	158-160	Cupredoxin superfamily protein	Arabidopsis thaliana	71-75
34389107-6	2021	In late gestation, suppression of maternal hepcidin, by as yet unknown factors, is required for increasing iron availability to the growing fetus.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	43-51
34389107-8	2021	In fetal hepatocytes, build up of fetal iron stores requires post-translational inhibition of FPN by the cell-autonomous action of hepcidin.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	131-139
28243203-3	2017	We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion.	Iron	121-125	RoBo-1	Rattus norvegicus	54-58
34389108-2	2021	At the systemic level, the iron-regulatory hormone hepcidin is secreted by the liver in response to serum iron levels and inflammation.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	51-59
28243203-3	2017	We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion.	Iron	230-234	RoBo-1	Rattus norvegicus	54-58
28243203-3	2017	We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion.	Iron	230-234	RoBo-1	Rattus norvegicus	54-58
34389108-2	2021	At the systemic level, the iron-regulatory hormone hepcidin is secreted by the liver in response to serum iron levels and inflammation.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	51-59
28243203-7	2017	These findings suggest that the nifedipine-induced increase in cell iron may mainly be due to the corresponding increase in TfR1 and DMT1 expression and also imply that the effects of nifedipine on iron transport in proximal tubule cells can not explain the increase in urinary iron excretion.	Iron	68-72	RoBo-1	Rattus norvegicus	133-137
34389108-3	2021	Hepcidin regulates the expression of the sole known mammalian iron exporter, ferroportin, to control dietary absorption, storage and tissue distribution of iron.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
34389108-3	2021	Hepcidin regulates the expression of the sole known mammalian iron exporter, ferroportin, to control dietary absorption, storage and tissue distribution of iron.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	0-8
34412763-5	2021	Its main mechanism is the intracellular lipid peroxidation induced by iron and the low expression of antioxidant systems (glutathione (GSH) and glutathione peroxidase 4 (GPX4)).	Iron	70-74	glutathione peroxidase 4	Homo sapiens	144-168
28144654-0	2017	The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.	Iron	53-55	lysine demethylase 4A	Homo sapiens	86-91
28144654-0	2017	The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.	Iron	53-55	lysine demethylase 4A	Homo sapiens	92-98
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	97-101	heat shock protein family B (small) member 1	Homo sapiens	0-36
28211731-2	2017	The measured time evolution of spin accumulation induced by laser excitation indicates transfer of angular momentum across normal metal/Y_{3}Fe_{5}O_{12} interfaces on a picosecond time scale, too short for contributions from a bulk temperature gradient in an yttrium iron garnet.	Iron	268-272	spindlin 1	Homo sapiens	31-35
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	97-101	heat shock protein family B (small) member 1	Homo sapiens	38-43
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	187-191	heat shock protein family B (small) member 1	Homo sapiens	0-36
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	Iron	71-75	siderophore transporter	Saccharomyces cerevisiae S288C	90-94
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	187-191	heat shock protein family B (small) member 1	Homo sapiens	38-43
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	Iron	71-75	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	181-186
27376881-3	2017	The hypersensitivity of the aft1Delta mutant to ALA was abrogated by surplus exogenous iron, suggesting that the role of Aft1p in ALA tolerance may be associated with iron limitation under ALA stress.	Iron	87-91	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	121-126
27376881-3	2017	The hypersensitivity of the aft1Delta mutant to ALA was abrogated by surplus exogenous iron, suggesting that the role of Aft1p in ALA tolerance may be associated with iron limitation under ALA stress.	Iron	167-171	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	121-126
28057442-2	2017	Ceruloplasmin/hephaestin double knockout mice (Cp/Heph DKO) and hepcidin knockout mice (Hepc KO) accumulate retinal iron and model some features of AMD.	Iron	116-120	hepcidin antimicrobial peptide	Mus musculus	64-72
28057442-3	2017	Two canonical pathways govern cellular iron import - transferrin-bound iron import and non-transferrin bound iron import.	Iron	39-43	transferrin	Mus musculus	53-64
28057442-3	2017	Two canonical pathways govern cellular iron import - transferrin-bound iron import and non-transferrin bound iron import.	Iron	39-43	transferrin	Mus musculus	91-102
34207028-3	2021	The result is compensatory hematopoietic expansion and impaired hepcidin production that causes increased intestinal iron absorption and progressive iron overload.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	64-72
28057442-3	2017	Two canonical pathways govern cellular iron import - transferrin-bound iron import and non-transferrin bound iron import.	Iron	71-75	transferrin	Mus musculus	53-64
28057442-3	2017	Two canonical pathways govern cellular iron import - transferrin-bound iron import and non-transferrin bound iron import.	Iron	71-75	transferrin	Mus musculus	53-64
28057442-4	2017	In Cp/Heph DKO and Hepc KO iron-loaded retinas, transferrin-bound iron import is downregulated.	Iron	27-31	transferrin	Mus musculus	48-59
28057442-4	2017	In Cp/Heph DKO and Hepc KO iron-loaded retinas, transferrin-bound iron import is downregulated.	Iron	66-70	transferrin	Mus musculus	48-59
28057442-11	2017	These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation.	Iron	96-100	transferrin	Mus musculus	78-89
34207028-3	2021	The result is compensatory hematopoietic expansion and impaired hepcidin production that causes increased intestinal iron absorption and progressive iron overload.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	64-72
28057442-11	2017	These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation.	Iron	138-142	transferrin	Mus musculus	78-89
34207028-12	2021	Another therapeutic approach is to target the dysregulation of iron homeostasis, using, for example, hepcidin agonists (inhibitors of TMPRSS6 and minihepcidins) or ferroportin inhibitors (VIT-2763).	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	101-109
34140491-3	2021	We apply the presented concept to ferritin, an iron storage protein, and its iron-free analog, apoferritin, in order to form single-layers, double-layers, as well as several types of 3D protein lattices.	Iron	77-81	ferritin heavy chain 1	Homo sapiens	95-106
28143953-7	2017	The expression levels of hemoglobin-haptoglobin receptor CD163 and hemopexin receptor CD91 were drastically reduced in both liver and spleen, resulting in heme- and hemoglobin-derived iron elimination in urine.	Iron	184-188	haptoglobin	Mus musculus	36-47
28143953-7	2017	The expression levels of hemoglobin-haptoglobin receptor CD163 and hemopexin receptor CD91 were drastically reduced in both liver and spleen, resulting in heme- and hemoglobin-derived iron elimination in urine.	Iron	184-188	low density lipoprotein receptor-related protein 1	Mus musculus	86-90
27439017-0	2017	Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C. BACKGROUND AND AIM: Pathological iron overload is commonly found in chronic hepatitis C (CHC) patients and considered as a negative prognostic factor of the disease.	Iron	130-134	mitochondrially encoded cytochrome b	Homo sapiens	60-72
34140491-6	2021	The framework design of the arrays then allows small molecules to access the ferritins and their iron cores and convert them into apoferritin arrays through the release of iron ions.	Iron	172-176	ferritin heavy chain 1	Homo sapiens	130-141
27439017-2	2017	In our study we investigated the impact of the CYBRD1 genotype and expression on iron overload in CHC patients.	Iron	81-85	cytochrome b reductase 1	Homo sapiens	47-53
34126941-3	2021	Hepcidin, a hormone that regulates iron homeostasis, is considered as an indicator of iron deficiency in patients with end-stage renal disease.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
27439017-8	2017	Hepatic expression of CYBRD1 was associated with the expression of Tfr2, Id1, and HO-1 genes, serum ferritin levels, and with increased iron accumulation in liver.	Iron	136-140	cytochrome b reductase 1	Homo sapiens	22-28
27439017-9	2017	CONCLUSION: These results implicate CYBRD1 involvement in iron homeostasis in CHC.	Iron	58-62	cytochrome b reductase 1	Homo sapiens	36-42
34126941-18	2021	Hepcidin levels were significantly correlated with ferritin levels, and it remains to be seen whether reducing hepcidin leads to improve ESA and iron availability during anemia management.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	111-119
27755990-1	2017	BACKGROUND: The antioxidant properties of alpha-lipoic acid (ALA) are associated with its ability to reduce iron in cells and tissues, which is partly due to its inhibiting effect on iron uptake from transferrin and its promoting effect on iron deposition into ferritin.	Iron	183-187	transferrin	Mus musculus	200-211
27755990-1	2017	BACKGROUND: The antioxidant properties of alpha-lipoic acid (ALA) are associated with its ability to reduce iron in cells and tissues, which is partly due to its inhibiting effect on iron uptake from transferrin and its promoting effect on iron deposition into ferritin.	Iron	183-187	transferrin	Mus musculus	200-211
34083630-7	2021	We also detected significant iron deposition in the injury site, a known catalyst for alpha-synuclein aggregation.	Iron	29-33	synuclein alpha	Homo sapiens	86-101
27755990-5	2017	This indicated that the inhibiting effect of ALA on DMT1 might be one of the causes of the ALA-induced reduction in cellular transferrin-bound-iron uptake.	Iron	143-147	transferrin	Mus musculus	125-136
28286877-2	2017	Using Citrobacter rodentium, a mouse enteric pathogen and Escherichia coli, a major cause of sepsis in humans as models, we find that interleukin-22, a cytokine best known for its ability to promote epithelial barrier function, also suppresses the systemic growth of bacteria by limiting iron availability to the pathogen.	Iron	288-292	interleukin 22	Homo sapiens	134-148
28286877-3	2017	Using an unbiased proteomic approach to understand the mechanistic basis of IL-22 dependent iron retention in the host, we have identified that IL-22 induces the production of the plasma hemoglobin scavenger haptoglobin and heme scavenger hemopexin.	Iron	92-96	haptoglobin	Mus musculus	208-219
27722771-10	2017	FERRITIN is important for iron storage in plants because it can store up to 4500 iron ions.	Iron	26-30	Fer2	Triticum aestivum	0-8
27722771-10	2017	FERRITIN is important for iron storage in plants because it can store up to 4500 iron ions.	Iron	81-85	Fer2	Triticum aestivum	0-8
34083630-10	2021	Compared to wild type mice, alpha-synuclein knockout mice had significantly more spared axons and neurons and lower pro-inflammatory mediators, macrophage accumulation, and iron deposition in the injured spinal cord.	Iron	173-177	synuclein, alpha	Mus musculus	28-43
34107639-7	2021	Immature reticulocyte fraction (IRF) and reticulocyte hemoglobin equivalent (Ret-He) were significantly higher in the iron deficient group as compared to alpha and beta thalassemia.	Iron	118-122	ret proto-oncogene	Homo sapiens	77-80
28115312-8	2017	Ovariectomy prevented iron-induced upregulation of ferritin, decreased myocardial SERCA2a levels, and increased NCX1 levels.	Iron	22-26	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	82-89
28115312-8	2017	Ovariectomy prevented iron-induced upregulation of ferritin, decreased myocardial SERCA2a levels, and increased NCX1 levels.	Iron	22-26	solute carrier family 8 (sodium/calcium exchanger), member 1	Mus musculus	112-116
34107639-9	2021	Sig-nificantly reduced levels of Ret-He were observed in alpha thalassemia and beta thalassemia in comparison to iron deficient group.	Iron	113-117	ret proto-oncogene	Homo sapiens	33-36
28115312-10	2017	The responses in wild-type and hemojuvelin-null female mice were remarkably similar, highlighting a conserved mechanism of sex-dependent protection from iron-overload-mediated cardiac injury.	Iron	153-157	hemojuvelin BMP co-receptor	Mus musculus	31-42
34107639-10	2021	While iron deficient group was characterized by increased values of RDW-SD, RDW-CV, IRF, and Ret-He.	Iron	6-10	ret proto-oncogene	Homo sapiens	93-96
34075924-4	2021	A moderate amount of Ca and Fe dopants keeps the B-site Co cations at a higher oxidation state (Co4+) and generates a vast amount of an oxygen defect rich structure.	Iron	28-30	complement C4A (Rodgers blood group)	Homo sapiens	96-99
28103306-0	2017	A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity.	Iron	51-55	AT695_RS09750	Staphylococcus aureus	2-22
34180813-0	2021	(Hepcidin: An iron hand in mucosal healing in inflammatory bowel diseases).	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	1-9
28001379-0	2017	The Two Faces of Tetramethylcyclam in Iron Chemistry: Distinct Fe-O-M Complexes Derived from [FeIV(Oanti/syn)(TMC)]2+ Isomers.	Iron	38-42	synemin	Homo sapiens	105-108
28001379-0	2017	The Two Faces of Tetramethylcyclam in Iron Chemistry: Distinct Fe-O-M Complexes Derived from [FeIV(Oanti/syn)(TMC)]2+ Isomers.	Iron	63-65	synemin	Homo sapiens	105-108
34394714-4	2021	Iron requirements increase during pregnancy and are influenced by hepcidin, the master regulator of iron homeostasis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	66-74
34394714-4	2021	Iron requirements increase during pregnancy and are influenced by hepcidin, the master regulator of iron homeostasis.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	66-74
28190144-1	2017	Streptococcal heme binding protein (Shp) is a surface protein of the heme acquisition system that is an essential iron nutrient in Group A Streptococcus (GAS).	Iron	114-118	nuclear receptor subfamily 0, group B, member 2	Mus musculus	36-39
34094899-6	2021	In addition, iron exposure also induced ferroptosis in CRC cells, but at the same time its inhibitory proteins SLC7A11 and GPX4 were also upregulated, indicating an enhanced resistance to ferroptosis.	Iron	13-17	solute carrier family 7 member 11	Homo sapiens	111-118
28828388-1	2017	Yeast MET18, a subunit of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery which is responsible for the maturation of Fe/S proteins, has been reported to participate in the oxidative stress response.	Iron	53-55	Met18p	Saccharomyces cerevisiae S288C	6-11
34094899-6	2021	In addition, iron exposure also induced ferroptosis in CRC cells, but at the same time its inhibitory proteins SLC7A11 and GPX4 were also upregulated, indicating an enhanced resistance to ferroptosis.	Iron	13-17	glutathione peroxidase 4	Homo sapiens	123-127
34068342-3	2021	In the yeast Saccharomyces cerevisiae, iron deficiency provokes a global impairment of translation at the initiation step, which is mediated by the Gcn2-eIF2alpha pathway, while the post-transcriptional regulator Cth2 specifically represses the translation of a subgroup of iron-related transcripts.	Iron	274-278	Tis11p	Saccharomyces cerevisiae S288C	213-217
27686598-0	2017	The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	37-45
27686598-10	2017	During hindlimb unloading, downregulation of hepcidin by siRNA increased iron uptake in bone and liver, which aggravated unloading-induced bone loss.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	45-53
34067098-2	2021	Inflammation can impact iron uptake and metabolism through elevation of hepcidin levels.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	72-80
29176318-0	2017	CCL2 is Upregulated by Decreased miR-122 Expression in Iron-Overload-Induced Hepatic Inflammation.	Iron	55-59	chemokine (C-C motif) ligand 2	Mus musculus	0-4
34063696-5	2021	To do so, we first investigated the structural impact of the Cys59Tyr mutation on BOLA3 by NMR, and then we analyzed how the mutation affects both the formation of a hetero-complex between BOLA3 and its protein partner GLRX5 and the iron-sulfur cluster-binding properties of the hetero-complex by various spectroscopic techniques and by experimentally driven molecular docking.	Iron	233-237	bolA family member 3	Homo sapiens	189-194
27658439-2	2017	Iron is an essential functional component of erythrocyte hemoglobin and its availability is controlled by the liver-derived hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	132-140
27658439-9	2017	Importantly, the sustained production of hepcidin allowed by erythroferrone ablation was associated with decreased parasitemia, providing further evidence that transient iron restriction could be beneficial in the treatment of malaria.	Iron	170-174	hepcidin antimicrobial peptide	Mus musculus	41-49
34063696-6	2021	We show that (1) the mutation structurally perturbed the iron-sulfur cluster-binding region of BOLA3, but without abolishing (2Fe-2S)2+ cluster-binding on the hetero-complex; (2) tyrosine 59 did not replace cysteine 59 as iron-sulfur cluster ligand; and (3) the mutation promoted the formation of an aberrant apo C59Y BOLA3-GLRX5 complex.	Iron	57-61	bolA family member 3	Homo sapiens	95-100
28550259-0	2017	Transport of Non-Transferrin Bound Iron to the Brain: Implications for Alzheimer"s Disease.	Iron	35-39	transferrin	Mus musculus	17-28
34063696-6	2021	We show that (1) the mutation structurally perturbed the iron-sulfur cluster-binding region of BOLA3, but without abolishing (2Fe-2S)2+ cluster-binding on the hetero-complex; (2) tyrosine 59 did not replace cysteine 59 as iron-sulfur cluster ligand; and (3) the mutation promoted the formation of an aberrant apo C59Y BOLA3-GLRX5 complex.	Iron	222-226	bolA family member 3	Homo sapiens	95-100
28550259-1	2017	A direct correlation between brain iron and Alzheimer"s disease (AD) raises questions regarding the transport of non-transferrin-bound iron (NTBI), a toxic but less researched pool of circulating iron that is likely to increase due to pathological and/or iatrogenic systemic iron overload.	Iron	135-139	transferrin	Mus musculus	117-128
28550259-1	2017	A direct correlation between brain iron and Alzheimer"s disease (AD) raises questions regarding the transport of non-transferrin-bound iron (NTBI), a toxic but less researched pool of circulating iron that is likely to increase due to pathological and/or iatrogenic systemic iron overload.	Iron	135-139	transferrin	Mus musculus	117-128
28550259-1	2017	A direct correlation between brain iron and Alzheimer"s disease (AD) raises questions regarding the transport of non-transferrin-bound iron (NTBI), a toxic but less researched pool of circulating iron that is likely to increase due to pathological and/or iatrogenic systemic iron overload.	Iron	135-139	transferrin	Mus musculus	117-128
28550259-2	2017	Here, we compared the distribution of radiolabeled-NTBI (59Fe-NTBI) and transferrin-bound iron (59Fe-Tf) in mouse models of iron overload in the absence or presence of inflammation.	Iron	90-94	transferrin	Mus musculus	72-83
34063273-2	2021	Increased systemic inflammation in obesity stimulates expression of the iron regulatory hormone hepcidin, which can result in a maldistribution of bodily iron, which may be implicated in metabolic dysfunction.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	96-104
29062571-1	2017	Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	0-8
29062571-1	2017	Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron.	Iron	187-191	hepcidin antimicrobial peptide	Mus musculus	0-8
29062571-11	2017	Our results highlight a modulatory effect of HO on iron homeostasis mediated through the suppression of hepatic hepcidin.	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	112-120
34063273-2	2021	Increased systemic inflammation in obesity stimulates expression of the iron regulatory hormone hepcidin, which can result in a maldistribution of bodily iron, which may be implicated in metabolic dysfunction.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	96-104
34063273-10	2021	Increased adiposity is associated with dysregulations in iron homeostasis, presenting as increased serum hepcidin, elevated serum ferritin and an increased risk of iron overload, with potential implications in impairments in metabolic health.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	105-113
34121709-5	2021	Aim: This study aimed to investigate the relationship between GSTP1 polymorphism and early complications of allo-HSCT, iron parameters, overall survival (OS), and transplantation-related mortality (TRM).	Iron	119-123	glutathione S-transferase pi 1	Homo sapiens	62-67
27741349-0	2017	Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	0-8
27741349-1	2017	Iron is both an essential and a potentially toxic element, and its systemic homeostasis is controlled by the iron hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	122-130
27741349-1	2017	Iron is both an essential and a potentially toxic element, and its systemic homeostasis is controlled by the iron hormone hepcidin.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	122-130
34099582-7	2021	Hepcidin is a primary regulator of iron metabolism in the human body.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
27741349-2	2017	Hepcidin binds to the cellular iron exporter ferroportin, causes its degradation, and thereby diminishes iron uptake from the intestine and the release of iron from macrophages.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	0-8
27741349-2	2017	Hepcidin binds to the cellular iron exporter ferroportin, causes its degradation, and thereby diminishes iron uptake from the intestine and the release of iron from macrophages.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	0-8
27741349-2	2017	Hepcidin binds to the cellular iron exporter ferroportin, causes its degradation, and thereby diminishes iron uptake from the intestine and the release of iron from macrophages.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	0-8
27741349-6	2017	Six-month-old hepcidin KO mice showed cytoplasmic acinar iron overload and mild pancreatitis, together with elevated expression of the iron uptake mediators DMT1 and Zip14.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	14-22
27741349-6	2017	Six-month-old hepcidin KO mice showed cytoplasmic acinar iron overload and mild pancreatitis, together with elevated expression of the iron uptake mediators DMT1 and Zip14.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	14-22
27741349-10	2017	Minihepcidin application to hepcidin KO mice led to an improvement in general health status and to iron redistribution from acinar cells to macrophages.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	4-12
34099582-8	2021	By promoting ferroportin degradation, hepcidin decreases the amount of iron in the circulation due to iron sequestration in the tissues and reduced intestinal absorption.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	38-46
27741349-12	2017	In conclusion, loss of hepcidin signalling in mice leads to iron overload-induced chronic pancreatitis that is not seen in situations with less severe iron accumulation.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	23-31
27741349-12	2017	In conclusion, loss of hepcidin signalling in mice leads to iron overload-induced chronic pancreatitis that is not seen in situations with less severe iron accumulation.	Iron	151-155	hepcidin antimicrobial peptide	Mus musculus	23-31
34099582-8	2021	By promoting ferroportin degradation, hepcidin decreases the amount of iron in the circulation due to iron sequestration in the tissues and reduced intestinal absorption.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	38-46
34099582-9	2021	Altered hepcidin concentration is a compensatory mechanism aimed at restoring iron homeostasis in various physiologic states, including pregnancy.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	8-16
35285505-0	2022	MIR164b represses iron uptake by regulating the NAC domain transcription factor5-Nuclear Factor Y, Subunit A8 module in Arabidopsis.	Iron	18-22	MIR164b	Arabidopsis thaliana	0-7
28188522-3	2017	Various methods have been devised for this purpose and we have recently described a Fe-IMAC HPLC column chromatography setup which is capable of comprehensive, reproducible, and selective enrichment of phosphopeptides out of complex peptide mixtures.	Iron	84-86	C-C motif chemokine ligand 26	Homo sapiens	87-91
28188522-6	2017	To increase throughput, we have optimized several key steps such as the gradient time of the Fe-IMAC separation (15 min per enrichment), the number of consecutive enrichments possible between two chargings (&gt;20) and the column recharging itself (&lt;1 h).	Iron	93-95	C-C motif chemokine ligand 26	Homo sapiens	96-100
35274348-2	2022	Hepcidin, the master regulator of iron, is secreted by the liver in response to interleukin 6 (IL-6) and/or bone morphogenetic protein 6 (BMP6) and can cause microcytosis.	Iron	34-38	hepcidin antimicrobial peptide	Canis lupus familiaris	0-8
28203361-8	2017	Iron-induced hypophosphataemic osteomalacia is thought to be due to reduced degradation of FGF23, resulting in phosphaturia and reduced synthesis of 1,25-dihydroxy vitamin D.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	91-96
28462381-12	2017	Alterations to ferroportin that prevent hepcidin binding during suckling may allow iron absorption to remain high regardless of hepcidin expression levels, reducing the likelihood of iron deficiency during development.	Iron	83-87	hepcidin antimicrobial peptide	Mus musculus	40-48
35274348-2	2022	Hepcidin, the master regulator of iron, is secreted by the liver in response to interleukin 6 (IL-6) and/or bone morphogenetic protein 6 (BMP6) and can cause microcytosis.	Iron	34-38	bone morphogenetic protein 6	Canis lupus familiaris	108-136
27768596-0	2016	Elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin-conducted iron egress.	Iron	99-103	zinc finger protein 217	Homo sapiens	23-29
35274348-2	2022	Hepcidin, the master regulator of iron, is secreted by the liver in response to interleukin 6 (IL-6) and/or bone morphogenetic protein 6 (BMP6) and can cause microcytosis.	Iron	34-38	bone morphogenetic protein 6	Canis lupus familiaris	138-142
27768596-4	2016	Increased of ZNF217 expression led to decreased FPN concentration, coupled with resultant intracellular iron retention, increased iron-related cellular activities and enhanced tumor cell growth.	Iron	104-108	zinc finger protein 217	Homo sapiens	13-19
35274348-9	2022	Non-HCC hepcidin RNA counts correlated negatively with MCV and positively with the extent of iron staining.	Iron	93-97	hepcidin antimicrobial peptide	Canis lupus familiaris	8-16
27768596-4	2016	Increased of ZNF217 expression led to decreased FPN concentration, coupled with resultant intracellular iron retention, increased iron-related cellular activities and enhanced tumor cell growth.	Iron	130-134	zinc finger protein 217	Homo sapiens	13-19
27768596-5	2016	In contrast, decreased of ZNF217 expression restrained tumor cell growth by promoting FPN-driven iron egress.	Iron	97-101	zinc finger protein 217	Homo sapiens	26-32
35618957-2	2022	On one side iron is essential to terminal erythropoiesis for hemoglobin production, on the other erythropoiesis may increase iron absorption through the production of erythroferrone, the erythroid hormone that suppresses hepcidin expression Also erythropoietin production is modulated by iron through the iron regulatory proteins-iron responsive elements that control the hypoxia inducible factor 2-alpha.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	221-229
27768596-9	2016	Collectively, this study underscored that elevated expression of ZNF217 promotes prostate cancer growth by restraining FPN-conducted iron egress.	Iron	133-137	zinc finger protein 217	Homo sapiens	65-71
35618957-2	2022	On one side iron is essential to terminal erythropoiesis for hemoglobin production, on the other erythropoiesis may increase iron absorption through the production of erythroferrone, the erythroid hormone that suppresses hepcidin expression Also erythropoietin production is modulated by iron through the iron regulatory proteins-iron responsive elements that control the hypoxia inducible factor 2-alpha.	Iron	12-16	endothelial PAS domain protein 1	Homo sapiens	372-404
35614872-2	2022	It was found to manipulate oncogenes and resistant mutations of cancer cells via lipid metabolism pathways converging on phospholipid glutathione peroxidase (GPX4) that squanders lipid peroxides (L-OOH) to block the iron-mediated reactions of peroxides, thus rendering resistant cancer cells vulnerable to ferroptotic cell death.	Iron	216-220	glutathione peroxidase 4	Homo sapiens	158-162
27450384-8	2016	The function of cFTR1 in Synechocystis could be genetically complemented by the iron permease, Ftr1p, of Saccharomyces cerevisiae, that is known to transport Fe3+ produced by the oxidation of Fe2+ via a multicopper oxidase.	Iron	80-84	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	95-100
35623439-5	2022	According to the theoretical calculations and experimental results, Fe-ions could be readily recovered from wastewater because it has the best adsorption efficiency among all other co-existing metals (Ni2+, Cd2+, Co2+, Cu2+, and Cr6+).	Iron	68-70	CD2 molecule	Homo sapiens	207-210
26687231-9	2016	Ferric iron can then undergo reduction to ferrous iron by ferrireductases inside endosomes followed by DMT1-mediated pumping into the cytosol and subsequently cellular export by ferroportin.	Iron	7-11	RoBo-1	Rattus norvegicus	103-107
35545893-3	2022	The aim was to study the ability of native and iron-saturated lactoferrin to reverse the effects of clindamycin on gut microbiota and intestinal Toll-like receptor (TLR) expression in a murine model.	Iron	47-51	lactotransferrin	Mus musculus	62-73
27784767-2	2016	We investigated the molecular function of a chloroplastic NFU-type iron-sulfur scaffold protein, NFU3, in Arabidopsis (Arabidopsis thaliana) using genetics approaches.	Iron	67-71	NFU domain protein 3	Arabidopsis thaliana	97-101
27784767-6	2016	Furthermore, the absorption spectrum of the recombinant NFU3 protein showed features characteristic of 4Fe-4S and 3Fe-4S clusters, and the in vitro reconstitution experiment indicated an iron-sulfur scaffold function of NFU3.	Iron	187-191	NFU domain protein 3	Arabidopsis thaliana	56-60
35595070-3	2022	Lactoferrin (LF), a glycoprotein belonging to the transferrin family, is known to play an important role in regulating iron homeostasis.	Iron	119-123	lactotransferrin	Rattus norvegicus	0-11
27897970-1	2016	Hepcidin is the master regulator of systemic iron homeostasis.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	0-8
27897970-7	2016	These findings are the first demonstration of a cell-autonomous role for hepcidin in iron homeostasis.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	73-81
35543697-2	2022	(Fe(CO) 5 )  + (Al(OR F ) 4 ) - was fully characterized (scXRD analysis, IR, NMR, EPR, 57 Fe spectroscopy, CV and SQUID magnetization study) and, apart from being a compound of fundamental interest, may serve as a precursor for low-valent iron coordination chemistry .	Iron	239-243	cortactin binding protein 2	Homo sapiens	16-27
27773819-7	2016	Knockout of FANCD2 increased ferroptosis-associated biochemical events (e.g., ferrous iron accumulation, glutathione depletion, and malondialdehyde production).	Iron	78-90	FA complementation group D2	Homo sapiens	12-18
35503147-4	2022	In dyeing effluents, the average concentrations of Zn, Cu, Pb, Mn, Fe and Cr ions were 5.50, 82.75, 6.80, 14.27, 66.03 and 65.28 mug mL-1, respectively, while the amount of Cd was barely detectable.	Iron	67-69	L1 cell adhesion molecule	Mus musculus	133-137
27773819-8	2016	Mechanically, FANCD2 regulated genes and/or expression of proteins involved in iron metabolism (e.g., FTH1, TF, TFRC, HAMP, HSPB1, SLC40A1, and STEAP3) and lipid peroxidation (e.g., GPX4).	Iron	79-83	FA complementation group D2	Homo sapiens	14-20
27849020-0	2016	The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision.	Iron	72-76	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	37-43
27849020-0	2016	The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision.	Iron	72-76	iron-regulated transporter 1	Arabidopsis thaliana	48-52
27849020-1	2016	Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana.	Iron	0-4	iron-regulated transporter 1	Arabidopsis thaliana	156-160
27849020-1	2016	Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana.	Iron	0-4	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	165-171
27849020-1	2016	Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana.	Iron	6-8	iron-regulated transporter 1	Arabidopsis thaliana	156-160
27849020-1	2016	Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana.	Iron	6-8	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	165-171
27849020-7	2016	We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants.	Iron	49-51	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	18-24
27849020-7	2016	We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants.	Iron	49-51	iron-regulated transporter 1	Arabidopsis thaliana	82-86
27849020-7	2016	We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants.	Iron	98-100	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	18-24
27849020-7	2016	We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants.	Iron	98-100	iron-regulated transporter 1	Arabidopsis thaliana	82-86
27849020-7	2016	We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants.	Iron	98-100	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	18-24
27849020-7	2016	We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants.	Iron	98-100	iron-regulated transporter 1	Arabidopsis thaliana	82-86
27772766-1	2016	BACKGROUND: Mitochondrial membrane protein-associated neurodegeneration (MPAN) is an neurodegeneration with brain iron accumulation (NBIA) subtype with mutation of C19orf12.	Iron	114-118	chromosome 19 open reading frame 12	Homo sapiens	164-172
27739682-5	2016	We found several crossings between the lowest energy spin states associated with the changes in Fe coordination.	Iron	96-98	spindlin 1	Homo sapiens	53-57
27740525-1	2016	BACKGROUND: Previous studies in high and low expressors has demonstrated that a variant in the GNPAT gene (D519G, Rs11558492, chromosome 1, exon 11) has been associated with severe iron overload in C282Y homozygotes for hemochromatosis.	Iron	181-185	glyceronephosphate O-acyltransferase	Homo sapiens	95-100
28203489-13	2016	These results suggest that despite their ability to induce hepcidin in tumors, the anti-tumor efficacy of systemic, non-targeted hepcidin antagonists may be limited by their ability to simultaneously elevate plasma iron.	Iron	215-219	hepcidin antimicrobial peptide	Mus musculus	129-137
27671242-1	2016	BACKGROUND: Mitochondrial membrane protein associated neurodegeneration (MPAN) is the third most common subtype of neurodegeneration with brain iron accumulation (NBIA) and caused by mutations of the orphan gene C19ORF12 encoding a transmembrane mitochondrial protein.	Iron	144-148	chromosome 19 open reading frame 12	Homo sapiens	212-220
27795405-5	2016	Specifically, similarly to baker"s yeast, Aft1 is the main positive regulator under iron starvation conditions, while Cth2 degrades mRNAs encoding iron-requiring enzymes.	Iron	84-88	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	42-46
27626109-0	2016	Redox Pairs of Diiron and Iron-Cobalt Complexes with High-Spin Ground States.	Iron	26-30	spindlin 1	Homo sapiens	58-62
27626109-5	2016	Zero- and applied-field Mossbauer spectra corroborate the presence of distinct oxidation and spin states for the iron sites.	Iron	113-117	spindlin 1	Homo sapiens	93-97
27667161-4	2016	This study aimed to explore the use of next-generation sequencing (NGS) technology to analyse a panel of iron metabolism-related genes (HFE, TFR2, HJV, HAMP, SLC40A1, and FTL) in 87 non-classic HH Portuguese patients.	Iron	105-109	ferritin light chain	Homo sapiens	171-174
27410488-1	2016	In conditions such as beta-thalassaemia, stimulated erythropoiesis can reduce the expression of the iron regulatory hormone hepcidin, increasing both macrophage iron release and intestinal iron absorption and leading to iron loading.	Iron	161-165	hepcidin antimicrobial peptide	Mus musculus	124-132
27410488-1	2016	In conditions such as beta-thalassaemia, stimulated erythropoiesis can reduce the expression of the iron regulatory hormone hepcidin, increasing both macrophage iron release and intestinal iron absorption and leading to iron loading.	Iron	161-165	hepcidin antimicrobial peptide	Mus musculus	124-132
27410488-1	2016	In conditions such as beta-thalassaemia, stimulated erythropoiesis can reduce the expression of the iron regulatory hormone hepcidin, increasing both macrophage iron release and intestinal iron absorption and leading to iron loading.	Iron	161-165	hepcidin antimicrobial peptide	Mus musculus	124-132
27499208-0	2016	Iron depletion-induced downregulation of N-cadherin expression inhibits invasive malignant phenotypes in human esophageal cancer.	Iron	0-4	cadherin 2	Homo sapiens	41-51
27499208-11	2016	In vitro study showed that decreased iron conditions inhibited esophageal cancer cell proliferation as well as migration and invasion abilities, with downregulation of N-cadherin expression.	Iron	37-41	cadherin 2	Homo sapiens	168-178
27499208-13	2016	In conclusion, decreased iron conditions revealed a profound anticancer effect by the suppression of tumor growth and the inhibition of migration and invasion abilities via N-cadherin.	Iron	25-29	cadherin 2	Homo sapiens	173-183
26762671-1	2016	BACKGROUND: Lipocalin 2 (LCN2) may be involved in the immunopathogenesis of multiple sclerosis (MS) and might further impact on iron homoeostasis.	Iron	128-132	lipocalin 2	Homo sapiens	12-23
26762671-1	2016	BACKGROUND: Lipocalin 2 (LCN2) may be involved in the immunopathogenesis of multiple sclerosis (MS) and might further impact on iron homoeostasis.	Iron	128-132	lipocalin 2	Homo sapiens	25-29
26762671-8	2016	In clinically stable patients, CSF LCN2 levels correlated with basal ganglia iron accumulation (r = 0.5, p &lt; 0.05).	Iron	77-81	lipocalin 2	Homo sapiens	35-39
26762671-10	2016	CONCLUSION: We demonstrate altered LCN2 regulation in early MS and provide first evidence for this to be possibly linked to both clinical MS activity and iron accumulation in the basal ganglia.	Iron	154-158	lipocalin 2	Homo sapiens	35-39
27353397-0	2016	The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions.	Iron	125-129	transthyretin	Homo sapiens	76-80
27353397-0	2016	The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions.	Iron	142-146	transthyretin	Homo sapiens	76-80
27353397-1	2016	Neisseria gonorrhoeae produces two transferrin binding proteins, TbpA and TbpB, which together enable efficient iron transport from human transferrin.	Iron	112-116	transthyretin	Homo sapiens	65-69
27353397-3	2016	The tbp genes were up-regulated in the misR mutant under iron-replete conditions but were conversely down-regulated in the misR mutant under iron-depleted conditions.	Iron	57-61	TATA-box binding protein	Homo sapiens	4-7
27353397-3	2016	The tbp genes were up-regulated in the misR mutant under iron-replete conditions but were conversely down-regulated in the misR mutant under iron-depleted conditions.	Iron	141-145	TATA-box binding protein	Homo sapiens	4-7
27434063-0	2016	High-Spin Iron(I) and Iron(0) Dinitrogen Complexes Supported by N-Heterocyclic Carbene Ligands.	Iron	22-26	spindlin 1	Homo sapiens	5-9
27434063-1	2016	The use of 1,3-dicyclohexylimidazol-2-ylidene (ICy) as ligand has enabled the preparation of the high-spin tetrahedral iron(I)- and iron(0)-N2 complexes, namely [(ICy)3 Fe(N2 )][BPh4 ] (1) and [(ICy)3 Fe(N2 )] (2), the electronic structures of which have been established by various spectroscopic characterization and DFT calculations.	Iron	119-123	spindlin 1	Homo sapiens	102-106
27434063-1	2016	The use of 1,3-dicyclohexylimidazol-2-ylidene (ICy) as ligand has enabled the preparation of the high-spin tetrahedral iron(I)- and iron(0)-N2 complexes, namely [(ICy)3 Fe(N2 )][BPh4 ] (1) and [(ICy)3 Fe(N2 )] (2), the electronic structures of which have been established by various spectroscopic characterization and DFT calculations.	Iron	132-136	spindlin 1	Homo sapiens	102-106
27434063-2	2016	The frequency of the N-N stretching resonance of the iron(0)-N2 complex is the lowest among the reported terminal N2 complexes of iron, signifying the beneficial roles of strongly sigma-donating ligands in combination with the high-spin low-valent iron center in promoting N2 -activation.	Iron	53-57	spindlin 1	Homo sapiens	232-236
27434063-2	2016	The frequency of the N-N stretching resonance of the iron(0)-N2 complex is the lowest among the reported terminal N2 complexes of iron, signifying the beneficial roles of strongly sigma-donating ligands in combination with the high-spin low-valent iron center in promoting N2 -activation.	Iron	130-134	spindlin 1	Homo sapiens	232-236
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	245-249	glyceronephosphate O-acyltransferase	Homo sapiens	69-105
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	245-249	glyceronephosphate O-acyltransferase	Homo sapiens	107-112
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	245-249	glyceronephosphate O-acyltransferase	Homo sapiens	277-282
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	glyceronephosphate O-acyltransferase	Homo sapiens	69-105
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	glyceronephosphate O-acyltransferase	Homo sapiens	107-112
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	glyceronephosphate O-acyltransferase	Homo sapiens	277-282
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	glyceronephosphate O-acyltransferase	Homo sapiens	69-105
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	glyceronephosphate O-acyltransferase	Homo sapiens	107-112
27661980-3	2016	Recently, a polymorphic variant (D519G, c.1556A&gt;G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption.	Iron	323-327	glyceronephosphate O-acyltransferase	Homo sapiens	277-282
27656882-0	2016	Electron Transport in a Dioxygenase-Ferredoxin Complex: Long Range Charge Coupling between the Rieske and Non-Heme Iron Center.	Iron	115-119	ferredoxin 1	Homo sapiens	36-46
27538670-2	2016	Neutrophil gelatinase-associated lipocalin (NGAL), an iron-handling and acute phase protein, may participate in the pathogenesis of TBI.	Iron	54-58	lipocalin 2	Homo sapiens	0-42
27538670-2	2016	Neutrophil gelatinase-associated lipocalin (NGAL), an iron-handling and acute phase protein, may participate in the pathogenesis of TBI.	Iron	54-58	lipocalin 2	Homo sapiens	44-48
27546061-0	2016	Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.	Iron	17-21	DGCR8 microprocessor complex subunit	Homo sapiens	38-43
27618952-2	2016	We show that yeast cells lacking Aft2, a transcription factor that together with Aft1 regulates iron homeostasis, are highly sensitive to selenite but, in contrast to aft1 mutants, this is not rescued by iron supplementation.	Iron	96-100	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	81-85
29263898-3	2016	Ceruloplasmin delivers iron to transferrin (Tf), the extracellular iron-transporting protein.	Iron	23-27	transferrin	Mus musculus	31-42
29263898-3	2016	Ceruloplasmin delivers iron to transferrin (Tf), the extracellular iron-transporting protein.	Iron	23-27	transferrin	Mus musculus	44-46
29263898-5	2016	Because Tf traffics iron away from iron-replete tissues, we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in PD.	Iron	20-24	transferrin	Mus musculus	8-10
29263898-5	2016	Because Tf traffics iron away from iron-replete tissues, we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in PD.	Iron	20-24	transferrin	Mus musculus	78-80
29263898-5	2016	Because Tf traffics iron away from iron-replete tissues, we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in PD.	Iron	35-39	transferrin	Mus musculus	78-80
29263898-5	2016	Because Tf traffics iron away from iron-replete tissues, we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in PD.	Iron	35-39	transferrin	Mus musculus	78-80
29263898-6	2016	In cultured neurons, Tf treatment corrected iron accumulation, and subcutaneous Tf to mice ameliorated iron accumulation and motor deficits in the MPTP model of PD.	Iron	44-48	transferrin	Mus musculus	21-23
29263898-6	2016	In cultured neurons, Tf treatment corrected iron accumulation, and subcutaneous Tf to mice ameliorated iron accumulation and motor deficits in the MPTP model of PD.	Iron	103-107	transferrin	Mus musculus	80-82
29263898-7	2016	Although these data support a role for Tf in the disease mechanism for PD, and its potential use for correcting disorders of iron overload, Tf therapy also caused systemic iron depletion, which could limit its application for PD.	Iron	172-176	transferrin	Mus musculus	140-142
27519943-1	2016	Hepcidin, a peptide produced in the liver, decreases intestinal iron absorption and macrophage iron release by causing degradation of the iron exporter, ferroportin.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	0-8
27519943-1	2016	Hepcidin, a peptide produced in the liver, decreases intestinal iron absorption and macrophage iron release by causing degradation of the iron exporter, ferroportin.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	0-8
27519943-1	2016	Hepcidin, a peptide produced in the liver, decreases intestinal iron absorption and macrophage iron release by causing degradation of the iron exporter, ferroportin.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	0-8
27514700-6	2016	Consistently, inhibition of ferritinophagy by blockage of autophagy or knockdown of NCOA4 abrogated the accumulation of ferroptosis-associated cellular labile iron and reactive oxygen species, as well as eventual ferroptotic cell death.	Iron	159-163	nuclear receptor coactivator 4	Homo sapiens	84-89
27514700-7	2016	Therefore, ferroptosis is an autophagic cell death process, and NCOA4-mediated ferritinophagy supports ferroptosis by controlling cellular iron homeostasis.	Iron	139-143	nuclear receptor coactivator 4	Homo sapiens	64-69
27079328-0	2016	Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes.	Iron	98-102	hemoglobin subunit gamma 2	Homo sapiens	32-45
27589737-6	2016	Iron chelators enhanced expressions of NDRG1 and NDRG3 while repressing cyclin D1 expression in OSCC cells.	Iron	0-4	N-myc downstream regulated 1	Homo sapiens	39-44
27589737-6	2016	Iron chelators enhanced expressions of NDRG1 and NDRG3 while repressing cyclin D1 expression in OSCC cells.	Iron	0-4	NDRG family member 3	Homo sapiens	49-54
27419260-5	2016	Interestingly, this spectacular nanoparticle breakdown barely affected iron homeostasis: only the genes coding for ferritin light chain (iron loading) and ferroportin (iron export) were up-regulated 2-fold by the degradation process.	Iron	137-141	ferritin light chain	Homo sapiens	115-135
27419260-5	2016	Interestingly, this spectacular nanoparticle breakdown barely affected iron homeostasis: only the genes coding for ferritin light chain (iron loading) and ferroportin (iron export) were up-regulated 2-fold by the degradation process.	Iron	137-141	ferritin light chain	Homo sapiens	115-135
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Iron	132-136	phosphorylase kinase catalytic subunit gamma 2	Homo sapiens	86-109
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Iron	132-136	phosphorylase kinase catalytic subunit gamma 2	Homo sapiens	111-116
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Iron	132-136	pumilio RNA binding family member 3	Homo sapiens	260-264
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Iron	132-136	pumilio RNA binding family member 3	Homo sapiens	327-331
27506793-6	2016	In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessary for ferroptosis and that the covalent inhibition of the catalytic selenocysteine in Gpx4 prevents elimination of PUFA hydroperoxides; these findings suggest new strategies for controlling ferroptosis in diverse contexts.	Iron	80-84	pumilio RNA binding family member 3	Homo sapiens	26-30
27506793-6	2016	In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessary for ferroptosis and that the covalent inhibition of the catalytic selenocysteine in Gpx4 prevents elimination of PUFA hydroperoxides; these findings suggest new strategies for controlling ferroptosis in diverse contexts.	Iron	80-84	phosphorylase kinase catalytic subunit gamma 2	Homo sapiens	64-69
27587995-2	2016	In order to investigate whether the ATP7A and the ATP7B genes may be transcriptionally regulated, we measured the expression level of the two genes at various concentrations of iron, copper, and insulin.	Iron	177-181	ATPase copper transporting beta	Homo sapiens	50-55
35585918-2	2022	Mutations in the ceruloplasmin gene cause depressed ferroxidase activity leading to iron accumulation.	Iron	84-88	ceruloplasmin	Homo sapiens	17-30
27587995-3	2016	Treating fibroblasts from controls or from individuals with MD or WD for 3 and 10 days with iron chelators revealed that iron deficiency led to increased transcript levels of both ATP7A and ATP7B.	Iron	92-96	ATPase copper transporting alpha	Homo sapiens	180-185
27587995-3	2016	Treating fibroblasts from controls or from individuals with MD or WD for 3 and 10 days with iron chelators revealed that iron deficiency led to increased transcript levels of both ATP7A and ATP7B.	Iron	92-96	ATPase copper transporting beta	Homo sapiens	190-195
27532424-7	2016	Lipid metabolism was the main pathway observed in the analysis of metabolic and canonical signaling pathways for the genes identified as DE, including the genes FASN, FABP4, and THRSP, which are functional candidates for beef quality, suggesting reduced lipogenic activities with lower iron content.	Iron	286-290	thyroid hormone responsive	Bos taurus	178-183
27487209-10	2016	In summary, the duplicative transposition of BOLA2 at the root of the H. sapiens lineage about 282 ka simultaneously increased copy number of a gene associated with iron homeostasis and predisposed our species to recurrent rearrangements associated with disease.	Iron	165-169	bolA family member 2	Homo sapiens	45-50
35393788-3	2022	The spin Hall angle of Pt1 -x (TiO2 )x in an yttrium iron garnet/Pt1 -x (TiO2 )x double-layer heterostructure is estimated from a combination of ferromagnetic resonance, spin pumping, and inverse spin Hall experiments.	Iron	53-57	zinc finger protein 77	Homo sapiens	23-26
27215149-10	2016	C-term FGF23 was significantly positively correlated with c-reactive protein (CRP) and negatively correlated with iron levels.	Iron	114-118	fibroblast growth factor 23	Homo sapiens	7-12
35393788-3	2022	The spin Hall angle of Pt1 -x (TiO2 )x in an yttrium iron garnet/Pt1 -x (TiO2 )x double-layer heterostructure is estimated from a combination of ferromagnetic resonance, spin pumping, and inverse spin Hall experiments.	Iron	53-57	zinc finger protein 77	Homo sapiens	65-68
27343690-0	2016	Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson"s disease.	Iron	99-103	transferrin	Mus musculus	81-92
35390708-4	2022	By consuming glutathione and oxidizing glucose to increase the H2O2 level in cancer cells and downregulating ferroportin 1 to accumulate intracellular iron ions, the homeostasis disruptor could effectively enhance the ferroptosis.	Iron	151-155	solute carrier family 40 member 1	Homo sapiens	109-122
27343690-2	2016	Here, we demonstrate that alpha-syn, the principal protein involved in the pathogenesis of PD, is expressed widely in the neuroretina, and facilitates the uptake of transferrin-bound iron (Tf-Fe) by retinal pigment epithelial (RPE) cells that form the outer blood-retinal barrier.	Iron	183-187	transferrin	Mus musculus	165-176
27462005-4	2016	TH1 purified through fusion with a His-tagged maltose-binding protein on amylose resin was representative of the iron-bound functional enzyme, showing high activity and stabilization by the natural feedback inhibitor dopamine.	Iron	113-117	negative elongation factor complex member C/D	Homo sapiens	0-3
35538889-0	2022	AMP-activated protein kinase alpha1 phosphorylates PHD2 to maintain systemic iron homeostasis.	Iron	77-81	egl-9 family hypoxia-inducible factor 1	Mus musculus	51-55
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	103-107	ceruloplasmin	Mus musculus	47-60
27191351-6	2016	Recent findings show that inflammation increases FGF23 production in bone through direct and iron-related indirect mechanisms.	Iron	93-97	fibroblast growth factor 23	Homo sapiens	49-54
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	128-132	ceruloplasmin	Mus musculus	47-60
35271829-4	2022	In mice, systemic knockout of the ferroxidases ceruloplasmin (Cp) and hephaestin (Heph), which oxidize iron, results in retinal iron accumulation and iron-induced degeneration.	Iron	150-154	ceruloplasmin	Mus musculus	47-60
35283192-9	2022	By combining mutations in the various iron acquisition loci (isd, fhuC, sst-1, and feo), we demonstrate that only a strain deficient for all of these systems was attenuated in its ability to proliferate to high numbers in the murine kidney.	Iron	38-42	susceptibility to tuberculosis 1	Mus musculus	72-77
27235625-0	2016	Human DNA polymerase epsilon is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.	Iron	102-106	cytosolic iron-sulfur assembly component 1	Homo sapiens	133-138
27235625-0	2016	Human DNA polymerase epsilon is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.	Iron	102-106	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	143-148
27235625-2	2016	We also describe novel interactions between POLE1 and the iron-sulfur cluster assembly complex CIA proteins CIAO1 and MMS19.	Iron	58-62	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	118-123
35101526-0	2022	COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.	Iron	96-98	ceruloplasmin	Homo sapiens	27-29
27262503-5	2016	There was a positive correlation (P &lt;0.001) between serum iron concentration, haematocrit (r(2) = 0.82) and delta-ALA-D activity (r(2) = 0.75).	Iron	61-65	aminolevulinate dehydratase	Gallus gallus	117-122
35624725-1	2022	Heme oxygenase-1 (HO-1) is an enzyme that catalyzes the degradation of heme, releasing equimolar amounts of carbon monoxide (CO), biliverdin (BV), and iron.	Iron	151-155	heme oxygenase 1	Homo sapiens	0-16
27208542-4	2016	Under an Fe-deficiency treatment, Col-0 showed more severe leaf chlorosis and root growth inhibition compared with the pad4 mutant.	Iron	9-11	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	119-123
27208542-5	2016	The soluble Fe concentrations were significantly higher in pad4 than in Col-0 under the Fe-deficiency treatment.	Iron	12-14	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	59-63
27208542-5	2016	The soluble Fe concentrations were significantly higher in pad4 than in Col-0 under the Fe-deficiency treatment.	Iron	88-90	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	59-63
27208542-6	2016	Fe deficiency significantly induced SA accumulation in Col-0 and the loss-of-function of PAD4 blocked this process.	Iron	0-2	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	89-93
35624725-1	2022	Heme oxygenase-1 (HO-1) is an enzyme that catalyzes the degradation of heme, releasing equimolar amounts of carbon monoxide (CO), biliverdin (BV), and iron.	Iron	151-155	heme oxygenase 1	Homo sapiens	18-22
35624725-3	2022	However, iron constitutes an important product of HO-1 activity involved in the regulation of several cellular biological processes.	Iron	9-13	heme oxygenase 1	Homo sapiens	50-54
27013087-0	2016	Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis.	Iron	0-4	transferrin receptor 2	Mus musculus	84-88
35547771-11	2022	Inhibition of SCD1/FADS2 directly downregulated GPX4 and the GSH/GSSG ratio, causing disruption of the cellular/mitochondrial redox balance and subsequently, iron-mediated lipid peroxidation and mitochondrial dysfunction in ascites-derived OvCa cells.	Iron	158-162	glutathione peroxidase 4	Homo sapiens	48-52
27013087-0	2016	Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	89-97
27013087-8	2016	Mechanistic studies revealed that downregulation and dysfunction of Tfr2 decreased hepcidin, leading to iron overload.	Iron	104-108	transferrin receptor 2	Mus musculus	68-72
27013087-8	2016	Mechanistic studies revealed that downregulation and dysfunction of Tfr2 decreased hepcidin, leading to iron overload.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	83-91
27013087-10	2016	Forced expression of Tfr2 in the murine liver reduced the iron accumulation.	Iron	58-62	transferrin receptor 2	Mus musculus	21-25
27013087-13	2016	CONCLUSIONS: Iron was severely overloaded in the HT1 mice via the Sp1/Tfr2/Hepcidin axis.	Iron	13-17	transferrin receptor 2	Mus musculus	70-74
27013087-13	2016	CONCLUSIONS: Iron was severely overloaded in the HT1 mice via the Sp1/Tfr2/Hepcidin axis.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	75-83
35528939-6	2022	However, not only genes involved in Fe homeostasis verified in strategy II plants (strategy II genes), which included ZmYS1, ZmYS3, and ZmTOM2, but also several genes associated with Fe homeostasis in strategy I plants (strategy I genes) were identified, including ZmFIT, ZmPYE, ZmILR3, ZmBTS, and ZmEIN2.	Iron	36-38	iron-phytosiderophore transporter yellow stripe 1	Zea mays	118-123
27498743-8	2016	In mice, hepatocyte-specific knockout of the TFR2 gene has been shown to cause systemic iron-overload with decreased expression of hepcidin, the central regulator of iron homeostasis.	Iron	88-92	transferrin receptor 2	Mus musculus	45-49
27498743-8	2016	In mice, hepatocyte-specific knockout of the TFR2 gene has been shown to cause systemic iron-overload with decreased expression of hepcidin, the central regulator of iron homeostasis.	Iron	166-170	transferrin receptor 2	Mus musculus	45-49
27498743-8	2016	In mice, hepatocyte-specific knockout of the TFR2 gene has been shown to cause systemic iron-overload with decreased expression of hepcidin, the central regulator of iron homeostasis.	Iron	166-170	hepcidin antimicrobial peptide	Mus musculus	131-139
27500074-1	2016	We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe (-/-) xTfr2 (mut) mouse model.	Iron	42-46	homeostatic iron regulator	Mus musculus	121-124
35528939-7	2022	Furthermore, strategy II gene ZmYS1 and strategy I gene ZmBTS were significantly upregulated in the Fe-deficient roots and shoots of maize inbred lines, and responded to Fe deficiency more in shoots than in roots.	Iron	100-102	iron-phytosiderophore transporter yellow stripe 1	Zea mays	30-35
35459748-5	2022	Elemental analysis measured stoichiometric quantities of Fe and Zn in yDbr1 purified following heterologous expression E. coli.	Iron	57-59	RNA lariat debranching enzyme	Saccharomyces cerevisiae S288C	70-75
27095094-11	2016	In iron-overloaded HSC-T6 cells, CCBs reduced iron deposition, inhibited proliferation, induced apoptosis, and elevated expression of matrix metalloproteinase-13 (MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1).	Iron	3-7	matrix metallopeptidase 13	Rattus norvegicus	134-161
27095094-11	2016	In iron-overloaded HSC-T6 cells, CCBs reduced iron deposition, inhibited proliferation, induced apoptosis, and elevated expression of matrix metalloproteinase-13 (MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1).	Iron	3-7	matrix metallopeptidase 13	Rattus norvegicus	163-169
35624674-8	2022	We further elucidated that PPARdelta modulated cellular iron homeostasis by regulating expression of divalent metal transporter 1, ferroportin 1, and ferritin, but not transferrin receptor 1, through iron regulatory protein 1 in 6-OHDA-treated cells.	Iron	56-60	solute carrier family 40 member 1	Homo sapiens	131-144
27095094-11	2016	In iron-overloaded HSC-T6 cells, CCBs reduced iron deposition, inhibited proliferation, induced apoptosis, and elevated expression of matrix metalloproteinase-13 (MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1).	Iron	3-7	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	175-214
27095094-11	2016	In iron-overloaded HSC-T6 cells, CCBs reduced iron deposition, inhibited proliferation, induced apoptosis, and elevated expression of matrix metalloproteinase-13 (MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1).	Iron	3-7	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	216-222
35137187-12	2022	ZmIRT1, ZmIRT2, and ZmYS1 may function in a cooperative manner to maintain Zn and Fe homeostasis in ZmIRT2 overexpressing plants.	Iron	82-84	iron-phytosiderophore transporter yellow stripe 1	Zea mays	20-25
27159412-9	2016	A theoretical model that considers spin-dependent electron transfer for the cases where the doubly occupied pi* orbital of the superoxo ligand is either "in" or "out" of the plane defined by the bent Fe-OO moiety correctly predicts that 1 has an S = 3 ground state, in contrast to the density functional theory calculations for 1, which give a ground state with both the wrong spin and orbital configuration.	Iron	200-202	spindlin 1	Homo sapiens	35-39
27159412-9	2016	A theoretical model that considers spin-dependent electron transfer for the cases where the doubly occupied pi* orbital of the superoxo ligand is either "in" or "out" of the plane defined by the bent Fe-OO moiety correctly predicts that 1 has an S = 3 ground state, in contrast to the density functional theory calculations for 1, which give a ground state with both the wrong spin and orbital configuration.	Iron	200-202	spindlin 1	Homo sapiens	377-381
35421237-10	2022	ROS and iron accumulation enhances the susceptibility of ME1 null cells to ferroptosis induction with inhibitors of xCT (erastin and ACXT-3102).	Iron	8-12	solute carrier family 7 member 11	Homo sapiens	116-119
27072365-1	2016	Hemojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepcidin expression through the BMP signaling pathway in the liver.	Iron	28-32	hemojuvelin BMP co-receptor	Mus musculus	0-11
27072365-1	2016	Hemojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepcidin expression through the BMP signaling pathway in the liver.	Iron	28-32	hemojuvelin BMP co-receptor	Mus musculus	13-16
27072365-5	2016	Expression of this mutant Hjv in the liver of Hjv(-/-) mice dramatically attenuated its induction of BMP signaling and hepcidin mRNA, suggesting that interaction with neogenin is critical for the iron regulatory function of HJV.	Iron	196-200	hemojuvelin BMP co-receptor	Mus musculus	26-29
27072365-5	2016	Expression of this mutant Hjv in the liver of Hjv(-/-) mice dramatically attenuated its induction of BMP signaling and hepcidin mRNA, suggesting that interaction with neogenin is critical for the iron regulatory function of HJV.	Iron	196-200	hemojuvelin BMP co-receptor	Mus musculus	46-49
35413222-8	2022	These findings suggest the ET-1/ETA signaling pathway contributes to in renal iron trafficking in a murine model of iron overload.	Iron	78-82	endothelin 1	Mus musculus	27-35
35413222-8	2022	These findings suggest the ET-1/ETA signaling pathway contributes to in renal iron trafficking in a murine model of iron overload.	Iron	116-120	endothelin 1	Mus musculus	27-35
27101151-1	2016	Although the interaction of low-spin ferric complexes with nitric oxide has been well studied, examples of stable high-spin ferric nitrosyls (such as those that could be expected to form at typical non-heme iron sites in biology) are extremely rare.	Iron	207-211	spindlin 1	Homo sapiens	119-123
35455056-0	2022	Enhanced Effects of Chronic Restraint-Induced Psychological Stress on Total Body Fe-Irradiation-Induced Hematopoietic Toxicity in Trp53-Heterozygous Mice.	Iron	81-83	transformation related protein 53	Mus musculus	130-135
27080262-0	2016	Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	95-103
27080262-13	2016	On the contrary, alcohol-induced decreases in hepatic Fe levels were seen and may contribute to alcohol-induced suppression of hepcidin.	Iron	54-56	hepcidin antimicrobial peptide	Mus musculus	127-135
35464433-2	2022	Iron metabolism is affected by erythroferrone through its capacity to inhibit hepcidin production, leading to the increase of iron availability required for erythropoiesis.	Iron	0-4	erythroferrone	Homo sapiens	31-45
27095402-4	2016	Lam induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast antioxidant system.	Iron	87-89	iron-regulated transporter 1	Arabidopsis thaliana	26-30
27342530-12	2016	CD8+ T cell apoptosis in iron overload group was significantly higher than that in control groups (P&lt;0.01); the expression of BCL-2 at mRNA level was lower than that in control group, but the expression of BAX at mRNA level was higher than that in control group (P&lt;0.05).	Iron	25-29	BCL2-associated X protein	Mus musculus	209-212
27342530-13	2016	These effects could be reversed after treating iron-overloaded mice with DFX or NAC.	Iron	47-51	NLR family, pyrin domain containing 1A	Mus musculus	80-83
27342530-15	2016	These effects may be regulated through increasing the intracellular ROS level, and can be partially reversed after treating iron-overloaded mice with DFX or NAC.	Iron	124-128	NLR family, pyrin domain containing 1A	Mus musculus	157-160
35464433-2	2022	Iron metabolism is affected by erythroferrone through its capacity to inhibit hepcidin production, leading to the increase of iron availability required for erythropoiesis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	78-86
27072134-4	2016	A small C-terminal domain of the catalytic subunit Pol3 carries both iron-sulfur cluster and zinc-binding motifs, which mediate interactions with Pol31, and processive replication with the replication clamp proliferating cell nuclear antigen (PCNA), respectively.	Iron	69-73	DNA-directed DNA polymerase delta POL3	Saccharomyces cerevisiae S288C	51-55
35464433-2	2022	Iron metabolism is affected by erythroferrone through its capacity to inhibit hepcidin production, leading to the increase of iron availability required for erythropoiesis.	Iron	126-130	erythroferrone	Homo sapiens	31-45
35464433-2	2022	Iron metabolism is affected by erythroferrone through its capacity to inhibit hepcidin production, leading to the increase of iron availability required for erythropoiesis.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	78-86
35464433-3	2022	However, little is known about erythroferrone function in other vertebrates, in particular teleost fish, that unlike mammals, present two different functional types of hepcidin, one type mostly involved in iron metabolism and the other in antimicrobial response.	Iron	206-210	hepcidin antimicrobial peptide	Homo sapiens	168-176
27228352-2	2016	The mutation consists of a GAA repeat expansion within the FXN gene, which downregulates frataxin, leading to abnormal mitochondrial iron accumulation, which may in turn cause changes in mitochondrial function.	Iron	133-137	frataxin	Mus musculus	59-62
27228352-2	2016	The mutation consists of a GAA repeat expansion within the FXN gene, which downregulates frataxin, leading to abnormal mitochondrial iron accumulation, which may in turn cause changes in mitochondrial function.	Iron	133-137	frataxin	Mus musculus	89-97
35464433-9	2022	In conclusion, in dual hepcidin teleost fish erythroferrone seems to only interact with type 1 hepcidin, known to be involved in iron homeostasis, but not with type 2, which has an almost exclusive antimicrobial role.	Iron	129-133	erythroferrone	Homo sapiens	45-59
35464433-9	2022	In conclusion, in dual hepcidin teleost fish erythroferrone seems to only interact with type 1 hepcidin, known to be involved in iron homeostasis, but not with type 2, which has an almost exclusive antimicrobial role.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	95-103
35385924-2	2022	One of the main causes of AoC is cancer-associated inflammation that activates mechanisms, commonly observed in anemia of inflammation, where functional iron deficiency and iron-restricted erythropoiesis is induced by increased hepcidin levels in response to IL-6 elevation.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	228-236
27168162-1	2016	PURPOSE: Lipocalin 2 (LCN2) is a secretory protein that is involved in various physiological processes including iron transport.	Iron	113-117	lipocalin 2	Homo sapiens	9-20
27168162-1	2016	PURPOSE: Lipocalin 2 (LCN2) is a secretory protein that is involved in various physiological processes including iron transport.	Iron	113-117	lipocalin 2	Homo sapiens	22-26
27168162-12	2016	CONCLUSIONS: These results indicated that LCN2 was involved in the migration and survival of endometrial carcinoma cells under various stresses in an iron-dependent manner.	Iron	150-154	lipocalin 2	Homo sapiens	42-46
35385924-9	2022	Trp53floxWapCre mice are the first mouse model where EPO-resistant anemia is described and may serve as a disease model to test therapeutic approaches for a subpopulation of human cancer patients with normal or corrected iron levels that do not respond to EPO.	Iron	221-225	erythropoietin	Mus musculus	53-56
27153075-0	2016	Oxidative Profile and delta-Aminolevulinate Dehydratase Activity in Healthy Pregnant Women with Iron Supplementation.	Iron	96-100	aminolevulinate dehydratase	Homo sapiens	22-55
35432536-9	2022	The levels of lipid ROS and iron were promoted by the treatment of erastin and the overexpression of KAT6B could reverse the effect in the cells.	Iron	28-32	lysine acetyltransferase 6B	Homo sapiens	101-106
27153075-2	2016	This study aimed to determine the oxidative profile and activity of delta-aminolevulinate dehydratase (delta-ALA-D) in pregnant women who received iron supplementation.	Iron	147-151	aminolevulinate dehydratase	Homo sapiens	68-101
27153075-2	2016	This study aimed to determine the oxidative profile and activity of delta-aminolevulinate dehydratase (delta-ALA-D) in pregnant women who received iron supplementation.	Iron	147-151	aminolevulinate dehydratase	Homo sapiens	103-114
27035325-2	2016	The hepcidin-ferroportin (FPN) axis is of critical importance in the maintenance of iron homeostasis.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	4-12
35453393-7	2022	Excessive iron intake leads to increased OS, inflammation, and an increased ratio of IL-12/IL-10 cytokines to the M1 macrophage phenotype.	Iron	10-14	interleukin 12B	Rattus norvegicus	85-90
27035325-3	2016	Hepcidin deficiency gives rise to enhanced dietary iron absorption, as well as to increased iron release from macrophages, and this in turn results in iron accumulation in the plasma and organs, and is associated with a range of tissue pathologies.	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	0-8
27035325-3	2016	Hepcidin deficiency gives rise to enhanced dietary iron absorption, as well as to increased iron release from macrophages, and this in turn results in iron accumulation in the plasma and organs, and is associated with a range of tissue pathologies.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	0-8
27035325-3	2016	Hepcidin deficiency gives rise to enhanced dietary iron absorption, as well as to increased iron release from macrophages, and this in turn results in iron accumulation in the plasma and organs, and is associated with a range of tissue pathologies.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	0-8
27035325-5	2016	Therapies that increase hepcidin concentrations may potentially play a role in the treatment of these iron overload-related diseases.	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	24-32
27035325-10	2016	The induction of hepcidin was confirmed in mice following icariin administration, coupled with associated changes in serum and tissue iron concentrations.	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	17-25
27035325-15	2016	The present study therefore highlights the significance of using natural compounds to ameliorate iron disorders through the regulation of hepcidin expression.	Iron	97-101	hepcidin antimicrobial peptide	Mus musculus	138-146
35453393-7	2022	Excessive iron intake leads to increased OS, inflammation, and an increased ratio of IL-12/IL-10 cytokines to the M1 macrophage phenotype.	Iron	10-14	interleukin 10	Rattus norvegicus	91-96
26979064-7	2016	Fluorescence intensity of PCaP1-GFP in roots was slightly decreased in seedlings grown in medium supplemented with high concentrations of iron for 1 week and increased in those grown with copper.	Iron	138-142	plasma-membrane associated cation-binding protein 1	Arabidopsis thaliana	26-31
35221009-0	2022	Expression of Concern: Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/beta-catenin pathway in colon cancer cells.	Iron	23-27	IL2 inducible T cell kinase	Homo sapiens	95-98
27014280-8	2016	Likewise, cue1 and HY1-OX lines with increased endogenous content of NO and CO, respectively, also exhibited enhanced Fe uptake and increased expression of bHLH transcriptional factor FIT1as compared to wild-type plants.	Iron	118-120	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	19-22
35221009-0	2022	Expression of Concern: Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/beta-catenin pathway in colon cancer cells.	Iron	23-27	catenin beta 1	Homo sapiens	124-136
35485210-9	2022	Moreover, LINC01606 protected colon cancer cells from ferroptosis by decreasing the concentration of iron, lipid reactive oxygen species, mitochondrial superoxide and increasing mitochondrial membrane potential.	Iron	101-105	long intergenic non-protein coding RNA 1606	Homo sapiens	10-19
26735394-1	2016	Induction of the iron regulatory hormone hepcidin contributes to the anemia of inflammation.	Iron	17-21	hepcidin antimicrobial peptide	Mus musculus	41-49
35384401-1	2022	Ferroptosis is iron-dependent, lipid peroxidation-driven, regulated cell death that is triggered when cellular glutathione peroxidase 4 (GPX4)-mediated cellular defense is insufficient to prevent pathologic accumulation of toxic lipid peroxides.	Iron	15-19	glutathione peroxidase 4	Mus musculus	137-141
26725301-4	2016	We highlight new regulators of iron metabolism, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron.	Iron	31-35	death associated protein kinase 3	Homo sapiens	154-157
26725301-4	2016	We highlight new regulators of iron metabolism, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron.	Iron	31-35	nuclear receptor coactivator 4	Homo sapiens	218-223
35292508-1	2022	Iron metabolism is tightly linked to infectious and inflammatory signals through hepcidin synthesis.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	81-89
26824729-5	2016	Liver DMT1 mRNA abundance was greater (P&lt;0 05) in MnSO4 than in the MnLys group for H-Fe rats.	Iron	89-91	RoBo-1	Rattus norvegicus	6-10
26824729-6	2016	The DMT1 protein in duodenum and liver and ferroportin 1 (FPN1) protein in liver was greater (P&lt;0 05) in the MnSO4 group than in the MnLys group, and in L-Fe rats than in H-Fe rats.	Iron	158-160	RoBo-1	Rattus norvegicus	4-8
35292508-3	2022	The aim of this study is to characterize the hepcidin and erythroid regulators (growth differentiation factor 15 (GDF-15) and erythroferrone (ERFE)) by measuring concentrations in plasma in context of COVID-19 disease.We performed a single-center observational study of patients with COVID-19 to evaluate concentrations of main regulatory proteins involved in iron homeostasis, namely: hepcidin, ERFE and GDF-15.	Iron	360-364	hepcidin antimicrobial peptide	Homo sapiens	45-53
26933678-0	2016	Constraints on Earth"s inner core composition inferred from measurements of the sound velocity of hcp-iron in extreme conditions.	Iron	102-106	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	98-101
35419301-2	2022	HO-1 catalyzes heme degradation, which gives rise to the formation of carbon monoxide (CO), biliverdin, and iron.	Iron	108-112	heme oxygenase 1	Homo sapiens	0-4
26933678-1	2016	Hexagonal close-packed iron (hcp-Fe) is a main component of Earth"s inner core.	Iron	23-27	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	29-32
26933678-1	2016	Hexagonal close-packed iron (hcp-Fe) is a main component of Earth"s inner core.	Iron	33-35	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	29-32
26933678-8	2016	Our results demonstrate that components other than Fe in Earth"s core are required to explain Earth"s core density and velocity deficits compared to hcp-Fe.	Iron	153-155	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	149-152
35346040-9	2022	Furthermore, in mnb1 mutants, the transcription level of the Fe uptake- and translocation-related genes, FIT, IRT1, FRO2, ZIF, FRD3, NAS4, PYE and MYB72, were considerably elevated during Fe-deficiency stress, resulting in enhanced Fe uptake and translocation, thereby increasing Fe accumulation.	Iron	61-63	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	139-142
26816269-7	2016	On the basis of mechanistic studies, we conclude that mononuclear nonheme high-spin iron(III)-acylperoxo complexes are strong oxidants capable of oxygenating hydrocarbons prior to their conversion into iron-oxo species via O-O bond cleavage.	Iron	84-88	spindlin 1	Homo sapiens	79-83
35346040-9	2022	Furthermore, in mnb1 mutants, the transcription level of the Fe uptake- and translocation-related genes, FIT, IRT1, FRO2, ZIF, FRD3, NAS4, PYE and MYB72, were considerably elevated during Fe-deficiency stress, resulting in enhanced Fe uptake and translocation, thereby increasing Fe accumulation.	Iron	61-63	myb domain protein 72	Arabidopsis thaliana	147-152
35403094-1	2022	Introduction: Hepcidin is a hormone that regulates systemic iron homeostasis.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	14-22
26871431-2	2016	Ferritin light chain (FTL), a key protein in iron metabolism, is associated with the survival of glioblastoma multiforme (GBM) patients; however, the molecular mechanisms underlying this association remain largely unclear.	Iron	45-49	ferritin light chain	Homo sapiens	0-20
26871431-2	2016	Ferritin light chain (FTL), a key protein in iron metabolism, is associated with the survival of glioblastoma multiforme (GBM) patients; however, the molecular mechanisms underlying this association remain largely unclear.	Iron	45-49	ferritin light chain	Homo sapiens	22-25
35403094-4	2022	We evaluated he diagnostic potential and limitations of hepcidin-25 by investigating its relationship with iron and hematological indices, inflammation, and renal dysfunction.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	56-64
26749241-0	2016	Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.	Iron	52-56	succinate dehydrogenase complex assembly factor 1	Homo sapiens	16-22
35405984-1	2022	Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	44-52
26749241-0	2016	Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.	Iron	52-56	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	69-73
26749241-2	2016	Here, we demonstrate that SDHAF1 contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB.	Iron	61-65	succinate dehydrogenase complex assembly factor 1	Homo sapiens	26-32
26749241-2	2016	Here, we demonstrate that SDHAF1 contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB.	Iron	61-65	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	98-123
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Iron	131-135	succinate dehydrogenase complex assembly factor 1	Homo sapiens	0-6
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Iron	131-135	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	49-53
35405984-1	2022	Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	44-52
26750974-12	2016	Upon higher CdCl2 concentration exposure, the release of iron content from transferrin was observed due to the interaction of CdCl2 with the key residues around iron binding sites.	Iron	57-61	transferrin	Mus musculus	75-86
26750974-12	2016	Upon higher CdCl2 concentration exposure, the release of iron content from transferrin was observed due to the interaction of CdCl2 with the key residues around iron binding sites.	Iron	161-165	transferrin	Mus musculus	75-86
35299233-1	2022	Hepcidin which is the crucial regulator of iron homeostasis, produced in the liver in response to anemia, hypoxia, or inflammation.	Iron	43-47	hepcidin antimicrobial peptide	Canis lupus familiaris	0-8
26635366-2	2016	These pleiotropic functions mainly rely on NGAL"s siderophore-mediated iron transport properties.	Iron	71-75	lipocalin 2	Homo sapiens	43-47
35341013-14	2022	The expression of EFHD2 was closely related to immune infiltration, among which 18 cancers were significantly correlated with CD8T cells, 14 cancers were significantly correlated with T regulatory (Tregs) cells, 15 cancers were significantly correlated with CD4 memory activated Tcells, and EFHD2 was significantly correlated with common tumor-related regulatory genes such as TGF beta signaling, TNFA signaling, hypoxia, scorch death, DNA repair, autophagy, and iron death-related genes.	Iron	463-467	EF-hand domain family member D2	Homo sapiens	18-23
35264787-3	2022	Inevitably, hepcidin, the iron hormone that maintains systemic iron homoeostasis is involved in HCC pathology.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	12-20
26453792-3	2016	Our aim was to investigate the impact of maternal iron status on infant FGF23 and mineral metabolites over the first 2years of life.	Iron	50-54	fibroblast growth factor 23	Homo sapiens	72-77
26453792-8	2016	In conclusion, this study suggests that poor maternal iron status is associated with a higher infant C-FGF23 and TALP but similar I-FGF23 concentrations in infants and young children.	Iron	54-58	fibroblast growth factor 23	Homo sapiens	103-108
26453792-8	2016	In conclusion, this study suggests that poor maternal iron status is associated with a higher infant C-FGF23 and TALP but similar I-FGF23 concentrations in infants and young children.	Iron	54-58	fibroblast growth factor 23	Homo sapiens	132-137
35264787-3	2022	Inevitably, hepcidin, the iron hormone that maintains systemic iron homoeostasis is involved in HCC pathology.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	12-20
26686468-4	2016	Clinically relevant levels of the thiosemicarbazone iron chelators triapine (Tp) and 2,2"-Dipyridyl-N,N-dimethylsemicarbazone (Dp44mT) promote selective oxidation of mitochondrial Prx3, but not cytosolic Prx1, in multiple human lung and ovarian cancer lines.	Iron	52-56	peroxiredoxin 3	Homo sapiens	180-184
35264864-2	2022	CP not only plays a crucial role in the metabolic balance of copper and iron through its oxidase function but also exhibits antioxidant activity.	Iron	72-76	ceruloplasmin	Homo sapiens	0-2
26077449-5	2016	Importantly our aging studies with the hemojuvelin knockout mice showed advanced liver disease in association with steatosis in the absence of a diabetic state which recapitulates the essential pathological features seen in clinical iron-overload.	Iron	233-237	hemojuvelin BMP co-receptor	Mus musculus	39-50
35264864-5	2022	Based on the physiological functions of CP, we provide an overview of the association of type 2 diabetes, obesity, hyperlipidemia, coronary heart disease, CP oxidative stress, inflammation, and metabolism of copper and iron.	Iron	219-223	ceruloplasmin	Homo sapiens	40-42
35264864-7	2022	Therefore, we conclude that CP, which can reduce the formation of free radicals in tissues, can be induced during inflammation and infection, and can correct the metabolic disorder of copper and iron, has protective and diagnostic effects on metabolic diseases.	Iron	195-199	ceruloplasmin	Homo sapiens	28-30
26752519-5	2016	Irp2 increased mitochondrial iron loading and levels of cytochrome c oxidase (COX), which led to mitochondrial dysfunction and subsequent experimental COPD.	Iron	29-33	iron responsive element binding protein 2	Mus musculus	0-4
35434035-3	2022	Over the past few years, extensive research has revealed that the essence of ferroptosis is iron-dependent accumulation of lipid hydroperoxides induced by oxidative stress, and the System Xc-glutathione (GSH)-glutathione peroxidase 4 (GPX4) pathway is the main ferroptosis prevention system.	Iron	92-96	glutathione peroxidase 4	Homo sapiens	235-239
26752519-6	2016	Frataxin-deficient mice, which had higher mitochondrial iron loading, showed impaired airway mucociliary clearance (MCC) and higher pulmonary inflammation at baseline, whereas mice deficient in the synthesis of cytochrome c oxidase, which have reduced COX, were protected from CS-induced pulmonary inflammation and impairment of MCC.	Iron	56-60	frataxin	Mus musculus	0-8
26644507-3	2016	Exogenous application of Suc further stimulated Fe deficiency-induced ferric-chelate-reductase (FCR) activity and expression of Fe acquisition-related genes FRO2, IRT1, and FIT in roots.	Iron	48-50	iron-regulated transporter 1	Arabidopsis thaliana	163-167
35041979-1	2022	ATP-binding cassette subfamily B member 7 (ABCB7) is localized in the inner membrane of mitochondria, playing a critical role in iron metabolism.	Iron	129-133	ATP binding cassette subfamily B member 7	Homo sapiens	0-41
27092272-6	2016	Our preliminary data confirm CHr as early and accurate predictor of hematological response to oral iron.	Iron	99-103	chromate resistance; sulfate transport	Homo sapiens	29-32
28127551-4	2016	Serum iron levels were lower in patients with NGAL &gt; 156 ng/mL than in those with NGAL &lt;= 156 ng/mL (27.4 +- 25.3 microg/dL versus 58.1 +- 43.5 microg/dL; P &lt; 0.001).	Iron	6-10	lipocalin 2	Homo sapiens	46-50
35041979-1	2022	ATP-binding cassette subfamily B member 7 (ABCB7) is localized in the inner membrane of mitochondria, playing a critical role in iron metabolism.	Iron	129-133	ATP binding cassette subfamily B member 7	Homo sapiens	43-48
35281042-7	2022	Being a highly infectious pathogenic bacterium, Mycobacterium tuberculosis (MTB) infection causes acute oxidative stress, and increases the expression of HO-1, which may in turn facilitate MTB survival and growth due to increased iron availability.	Iron	230-234	heme oxygenase 1	Homo sapiens	154-158
26718588-0	2016	Noradrenergic-Dopaminergic Interactions Due to DSP-4-MPTP Neurotoxin Treatments: Iron Connection.	Iron	81-85	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	53-57
35281042-8	2022	Moreover, in severe cases of MTB infection, excessive reactive oxygen species (ROS) and free iron (Fe2+) due to high levels of HO-1 can lead to lipid peroxidation and ferroptosis, which may promote further MTB dissemination from cells undergoing ferroptosis.	Iron	93-97	heme oxygenase 1	Homo sapiens	127-131
35133148-3	2022	We demonstrated that iron treatment enhanced the expression of cGAS, STING, and their downstream targets, including TBK1, IRF-3, and NF-kappaB in HepG2 cells and mice liver.	Iron	21-25	TANK binding kinase 1	Homo sapiens	116-120
27829333-12	2016	CONCLUSION: Iron overload can affect humeral and cell mediated immunity in patients with beta thalassemia with reduction of IgM, CD3 and CD4 and elevation of CD8, IgG, and IgA.	Iron	12-16	CD8a molecule	Homo sapiens	158-161
27143982-2	2016	Our findings suggest that YGS regulates iron homeostasis by downregulating the level of HAMP mRNA, which may depend on regulation of the IL-6/STAT3 or BMP/HJV/SMAD pathway during acute inflammation.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	88-92
35045311-5	2022	Dietary iron overload also decreased mRNA and protein expression levels of glutathione peroxidase 4 (GPX4) and cystine-glutamate antiporter (SLC7A11), and increased mRNA and protein expression of acyl-CoA synthetase long-chain family member 4 (ACSL4), which are all markers of ferroptosis.	Iron	8-12	glutathione peroxidase 4	Homo sapiens	75-99
26406355-0	2016	Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.	Iron	111-115	homeostatic iron regulator	Mus musculus	73-76
35045311-5	2022	Dietary iron overload also decreased mRNA and protein expression levels of glutathione peroxidase 4 (GPX4) and cystine-glutamate antiporter (SLC7A11), and increased mRNA and protein expression of acyl-CoA synthetase long-chain family member 4 (ACSL4), which are all markers of ferroptosis.	Iron	8-12	glutathione peroxidase 4	Homo sapiens	101-105
26406355-0	2016	Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.	Iron	111-115	transferrin receptor 2	Mus musculus	81-103
26406355-1	2016	UNLABELLED: Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes.	Iron	124-128	homeostatic iron regulator	Mus musculus	211-214
35045311-5	2022	Dietary iron overload also decreased mRNA and protein expression levels of glutathione peroxidase 4 (GPX4) and cystine-glutamate antiporter (SLC7A11), and increased mRNA and protein expression of acyl-CoA synthetase long-chain family member 4 (ACSL4), which are all markers of ferroptosis.	Iron	8-12	solute carrier family 7 member 11	Homo sapiens	141-148
26406355-1	2016	UNLABELLED: Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes.	Iron	124-128	transferrin receptor 2	Mus musculus	216-238
26406355-1	2016	UNLABELLED: Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes.	Iron	150-154	homeostatic iron regulator	Mus musculus	211-214
35045311-9	2022	Experiments with HEK293T cells revealed that Fe-induced ferroptosis involved direct inhibition of NRF2 binding to antioxidant response elements (AREs) within the promoters of the gpx4 and slc7a11 genes, which in turn induced transcriptional silencing.	Iron	45-47	glutathione peroxidase 4	Homo sapiens	179-183
35045311-9	2022	Experiments with HEK293T cells revealed that Fe-induced ferroptosis involved direct inhibition of NRF2 binding to antioxidant response elements (AREs) within the promoters of the gpx4 and slc7a11 genes, which in turn induced transcriptional silencing.	Iron	45-47	solute carrier family 7 member 11	Homo sapiens	188-195
35181698-2	2022	Dietary non-heme iron is physiologically absorbed via the divalent metal transporter-1 (DMT1) pathway.	Iron	17-21	solute carrier family 11 member 2	Homo sapiens	58-86
26484920-2	2016	We have shown in this study that chelatable iron accumulates in the aged rat brain along with overexpression of transferrin receptor 1 (TfR1) and ferritin, accompanied by significant alterations in amyloid-beta (Abeta) peptide homeostasis in the aging brain, such as an increased production of the amyloid-beta protein precursor, a decreased level of neprilysin, and increased accumulation of Abeta42.	Iron	44-48	membrane metallo-endopeptidase	Rattus norvegicus	351-361
35181698-2	2022	Dietary non-heme iron is physiologically absorbed via the divalent metal transporter-1 (DMT1) pathway.	Iron	17-21	solute carrier family 11 member 2	Homo sapiens	88-92
35181867-9	2022	qPCR analysis of differentiated RBCs revealed increased HAMP mRNA expression levels, encoding for hepcidin, which inhibits iron uptake.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	56-60
26621032-5	2016	Suppression of NAF-1 resulted in increased uptake of Fe ions into cells, a metabolic shift that rendered cells more susceptible to a glycolysis inhibitor, and the activation of cellular stress pathways that are associated with HIF1alpha.	Iron	53-55	CDGSH iron sulfur domain 2	Homo sapiens	15-20
35181867-9	2022	qPCR analysis of differentiated RBCs revealed increased HAMP mRNA expression levels, encoding for hepcidin, which inhibits iron uptake.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	98-106
26621032-6	2016	Our studies suggest that NAF-1 is a major player in the metabolic regulation of breast cancer cells through its effects on cellular Fe ion distribution, mitochondrial metabolism and the induction of apoptosis.	Iron	132-134	CDGSH iron sulfur domain 2	Homo sapiens	25-30
35177695-2	2022	Hepcidin, a regulator of iron metabolism, is involved in iron pathophysiology during inflammation.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
26657863-1	2016	Iron homeostasis is tightly regulated by the membrane iron exporter ferroportin and its regulatory peptide hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	115-123
35177695-2	2022	Hepcidin, a regulator of iron metabolism, is involved in iron pathophysiology during inflammation.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
35172141-6	2022	Genetic deletion of IL-6, or treatment with the iron chelator deferiprone, reduces pathological alpha-syn toxicity in a mouse model of sporadic PD.	Iron	48-52	synuclein, alpha	Mus musculus	96-105
27423740-2	2016	Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	0-8
27423740-2	2016	Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	10-15
27423740-3	2016	Mice lacking Hamp1 from birth rapidly accumulate iron and are susceptible to infection by blood-dwelling siderophilic bacteria such as Vibrio vulnificus.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	13-18
35048936-3	2022	Benefiting from the hierarchical structure, the exposure of more active sites and the doping effect of N and Fe, the N-Fe-Ni3S2@NiP2/NF material showed excellent electrocatalytic activity for the OER and UOR.	Iron	109-111	BCL2 interacting protein 2	Homo sapiens	128-132
26578707-7	2016	However, the FCR activity and the expression of genes related to Fe uptake were still up-regulated under -Fe+Put treatment compared with -Fe treatment in xth31, and Put-induced cell wall Fe remobilization was abolished in noa1 and nia1nia2, indicating that Put-regulated cell wall Fe reutilization is dependent on NO.	Iron	106-108	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	222-226
26578707-7	2016	However, the FCR activity and the expression of genes related to Fe uptake were still up-regulated under -Fe+Put treatment compared with -Fe treatment in xth31, and Put-induced cell wall Fe remobilization was abolished in noa1 and nia1nia2, indicating that Put-regulated cell wall Fe reutilization is dependent on NO.	Iron	106-108	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	222-226
26578707-7	2016	However, the FCR activity and the expression of genes related to Fe uptake were still up-regulated under -Fe+Put treatment compared with -Fe treatment in xth31, and Put-induced cell wall Fe remobilization was abolished in noa1 and nia1nia2, indicating that Put-regulated cell wall Fe reutilization is dependent on NO.	Iron	106-108	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	222-226
26646468-5	2015	It was found that the hydroxyl radicals generation rate constant of syn-FeS2 Fenton system was 71 times that of its com-FeS2 counterpart, and even 1-3 orders of magnitude larger than those of commonly used Fe-bearing heterogeneous catalysts.	Iron	72-74	synemin	Homo sapiens	68-71
35204772-3	2022	Yet, corrections need to be made for samples that absorb light at the wavelength of the MALS laser, such as iron-sulfur (Fe-S) cluster-containing proteins.	Iron	121-125	natural cytotoxicity triggering receptor 3	Homo sapiens	88-92
32263029-2	2015	Due to the physico-chemical properties of Pt-NPs (electroactivity) and MIL-100(Fe) (high specific surface area and pore volume, biocompatibility), the resulting GOx-MIL-100(Fe)-PtNP bioelectrode exhibits excellent electrocatalytic performances for glucose detection.	Iron	79-81	hydroxyacid oxidase 1	Homo sapiens	161-164
35163840-0	2022	Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	23-31
32263029-2	2015	Due to the physico-chemical properties of Pt-NPs (electroactivity) and MIL-100(Fe) (high specific surface area and pore volume, biocompatibility), the resulting GOx-MIL-100(Fe)-PtNP bioelectrode exhibits excellent electrocatalytic performances for glucose detection.	Iron	173-175	hydroxyacid oxidase 1	Homo sapiens	161-164
35163840-0	2022	Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	23-31
35163840-1	2022	Pathogenic TMPRSS6 variants impairing matriptase-2 function result in inappropriately high hepcidin levels relative to body iron status, leading to iron refractory iron deficiency anemia (IRIDA).	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	91-99
26407665-3	2015	Here we compare the influence of hydrogen peroxide and the ferrous iron (reagent for Fenton reaction) on the enzymatic activity of recombinant CD45, LAR, PTP1B phosphatases and cellular CD45 in Jurkat cells.	Iron	59-71	protein tyrosine phosphatase receptor type C	Homo sapiens	143-147
26407665-3	2015	Here we compare the influence of hydrogen peroxide and the ferrous iron (reagent for Fenton reaction) on the enzymatic activity of recombinant CD45, LAR, PTP1B phosphatases and cellular CD45 in Jurkat cells.	Iron	59-71	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	154-159
35163840-8	2022	The TSAT/hepcidin ratio shows excellent performance in discriminating IRIDA from TMPRSS6-unrelated IDA early in the diagnostic work-up of IDA provided that recent iron therapy and moderate-to-severe inflammation are absent.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	9-17
26407665-3	2015	Here we compare the influence of hydrogen peroxide and the ferrous iron (reagent for Fenton reaction) on the enzymatic activity of recombinant CD45, LAR, PTP1B phosphatases and cellular CD45 in Jurkat cells.	Iron	59-71	protein tyrosine phosphatase receptor type C	Homo sapiens	186-190
26407665-5	2015	We found that the higher concentrations of ferrous iron (II) increase the inactivation of CD45, LAR and PTP1B phosphatase caused by hydrogen peroxide, but the addition of the physiological concentration (500 nM) of ferrous iron (II) has even a slightly preventive effect on the phosphatase activity against hydrogen peroxide.	Iron	43-55	protein tyrosine phosphatase receptor type C	Homo sapiens	90-94
35141461-5	2022	Reverse genetic analysis using artificial microRNA (amiRNA) to generate lines with reduced CrATX1 abundance and CRISPR/Cpf1 to generate atx1 knockout lines validated a function for ATX1 in iron-poor cells, again reminiscent of yeast ATX1, most likely because of an impact on metalation of the multicopper oxidase FOX1, which is an important component in high-affinity iron uptake.	Iron	189-193	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	181-185
26407665-5	2015	We found that the higher concentrations of ferrous iron (II) increase the inactivation of CD45, LAR and PTP1B phosphatase caused by hydrogen peroxide, but the addition of the physiological concentration (500 nM) of ferrous iron (II) has even a slightly preventive effect on the phosphatase activity against hydrogen peroxide.	Iron	43-55	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	104-109
26414080-6	2015	Other calciotropic hormones including fibroblast growth factor 23, and parathyroid hormone have also been found to be associated with iron homeostasis and erythropoiesis.	Iron	134-138	fibroblast growth factor 23	Homo sapiens	38-65
35141461-5	2022	Reverse genetic analysis using artificial microRNA (amiRNA) to generate lines with reduced CrATX1 abundance and CRISPR/Cpf1 to generate atx1 knockout lines validated a function for ATX1 in iron-poor cells, again reminiscent of yeast ATX1, most likely because of an impact on metalation of the multicopper oxidase FOX1, which is an important component in high-affinity iron uptake.	Iron	368-372	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	181-185
34171864-10	2022	Serum hepcidin was higher in the iron group than in the control group at POD 3 (106.3 (42.9-115.9) ng/ml vs. 39.3 (33.3-43.6) ng/ml, P < 0.001).	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	6-14
26569073-0	2015	Effects of Il-33/St2 pathway on alteration of iron and hematological parameters in acute inflammation.	Iron	46-50	interleukin 33	Mus musculus	11-16
26569073-0	2015	Effects of Il-33/St2 pathway on alteration of iron and hematological parameters in acute inflammation.	Iron	46-50	interleukin 1 receptor-like 1	Mus musculus	17-20
26569073-1	2015	AIM: The aim of this study was to examine the role of the IL-33/ST2 pathway in pathogenesis of acute inflammation by investigating its possible role in alteration of iron and hematological parameters in experimental model of acute inflammation.	Iron	166-170	interleukin 33	Mus musculus	58-63
34171864-12	2022	CONCLUSIONS: Intravenous iron supplementation during index hospitalization for complex cardiac surgery did not minimize pRBC transfusion despite replenished iron store and augmented erythropoiesis, which may be attributed to enhanced hepcidin expression.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	234-242
26569073-1	2015	AIM: The aim of this study was to examine the role of the IL-33/ST2 pathway in pathogenesis of acute inflammation by investigating its possible role in alteration of iron and hematological parameters in experimental model of acute inflammation.	Iron	166-170	interleukin 1 receptor-like 1	Mus musculus	64-67
26569073-6	2015	RESULTS: Iron concentration in the treated tissue was significantly higher in wild-type inflammatory group (WT-I) when compared to both, the wild-type control group (WT-C) and ST2-/- inflammatory group (KO-I).	Iron	9-13	interleukin 1 receptor-like 1	Mus musculus	176-179
26569073-12	2015	CONCLUSION: Results of this study indicate that the IL-33/ST2 axis could have a role in the alteration of iron in acute inflammation, namely in an increase of iron concentration at the site of acute inflammation and a decrease of blood mean corpuscular hemoglobin.	Iron	106-110	interleukin 33	Mus musculus	52-57
26569073-12	2015	CONCLUSION: Results of this study indicate that the IL-33/ST2 axis could have a role in the alteration of iron in acute inflammation, namely in an increase of iron concentration at the site of acute inflammation and a decrease of blood mean corpuscular hemoglobin.	Iron	106-110	interleukin 1 receptor-like 1	Mus musculus	58-61
26569073-12	2015	CONCLUSION: Results of this study indicate that the IL-33/ST2 axis could have a role in the alteration of iron in acute inflammation, namely in an increase of iron concentration at the site of acute inflammation and a decrease of blood mean corpuscular hemoglobin.	Iron	159-163	interleukin 33	Mus musculus	52-57
26569073-12	2015	CONCLUSION: Results of this study indicate that the IL-33/ST2 axis could have a role in the alteration of iron in acute inflammation, namely in an increase of iron concentration at the site of acute inflammation and a decrease of blood mean corpuscular hemoglobin.	Iron	159-163	interleukin 1 receptor-like 1	Mus musculus	58-61
35001811-3	2022	Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act as positive regulators of PRKN-independent mitophagy.	Iron	6-10	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	38-42
26450372-1	2015	We have identified a new downstream target gene of the Aft1/2-regulated iron regulon in budding yeast Saccharomyces cerevisiae, the late-annotated small open reading frame LSO1.	Iron	72-76	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	55-61
26450372-4	2015	In contrast, we find that the LSO1 promoter region contains three consensus binding sites for the Aft1/2 transcription factors and that an LSO1-lacZ reporter is highly induced under low-iron conditions in a Aft1-dependent manner.	Iron	186-190	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	98-104
35001811-3	2022	Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act as positive regulators of PRKN-independent mitophagy.	Iron	6-10	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	208-212
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	101-105	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	65-69
35001849-2	2022	Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of cd70, cd11a, and cd40l genes among CD4 + T cells.	Iron	122-126	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	65-69
25728296-4	2015	Information about the spin-dependent unoccupied bands of the Fe film in the GammaNu direction normal to the film plane is obtained by analyzing the observed quantum well resonance conditions.	Iron	61-63	spindlin 1	Homo sapiens	22-26
26396185-6	2015	To address whether Erv1 or Mia40 plays a role in iron regulation, we measured iron-dependent expression of Aft1/2-regulated genes and mitochondrial iron accumulation in erv1 and mia40 strains.	Iron	78-82	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	107-113
35218933-3	2022	Thus, in response to iron deficiency, transcription factors Aft1 and Aft2 activate the expression of genes implicated in iron acquisition and mobilization, whereas two mRNA-binding proteins, Cth1 and Cth2, posttranscriptionally control iron metabolism.	Iron	236-240	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	191-195
26396185-6	2015	To address whether Erv1 or Mia40 plays a role in iron regulation, we measured iron-dependent expression of Aft1/2-regulated genes and mitochondrial iron accumulation in erv1 and mia40 strains.	Iron	78-82	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	107-113
35218933-3	2022	Thus, in response to iron deficiency, transcription factors Aft1 and Aft2 activate the expression of genes implicated in iron acquisition and mobilization, whereas two mRNA-binding proteins, Cth1 and Cth2, posttranscriptionally control iron metabolism.	Iron	121-125	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	191-195
26457760-4	2015	The solid-state structures of (L1)2Fe(OTf)(ClO4) and (L3)2Fe(OTf)2 are reported, showing a low-spin octahedral iron center, with the ligands arranged in a meridional fashion.	Iron	111-115	POU class 2 homeobox 2	Homo sapiens	61-66
35225679-0	2022	Estimates of West African Ancestry in African Americans Using Alleles of Iron-Related Genes HJV, SLC40A1, and TFR2.	Iron	73-77	hemojuvelin BMP co-receptor	Homo sapiens	92-95
35225679-0	2022	Estimates of West African Ancestry in African Americans Using Alleles of Iron-Related Genes HJV, SLC40A1, and TFR2.	Iron	73-77	solute carrier family 40 member 1	Homo sapiens	97-104
35225679-0	2022	Estimates of West African Ancestry in African Americans Using Alleles of Iron-Related Genes HJV, SLC40A1, and TFR2.	Iron	73-77	transferrin receptor 2	Homo sapiens	110-114
26337137-3	2015	To identify a novel molecular starting point with favorable physicochemical properties for the investigation of the physiological role of KDM4A, we screened a number of molecules bearing an iron-chelating moiety by using two independent assays.	Iron	190-194	lysine demethylase 4A	Homo sapiens	138-143
35225679-2	2022	In sub-Saharan West African (WA) Blacks, some nonancestral alleles of iron-related genes HJV, SLC40A1, and TFR2 are common, whereas in European Americans (EA) the same alleles are rare.	Iron	70-74	hemojuvelin BMP co-receptor	Homo sapiens	89-92
35225679-2	2022	In sub-Saharan West African (WA) Blacks, some nonancestral alleles of iron-related genes HJV, SLC40A1, and TFR2 are common, whereas in European Americans (EA) the same alleles are rare.	Iron	70-74	solute carrier family 40 member 1	Homo sapiens	94-101
26318828-0	2015	Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy.	Iron	0-4	lipocalin 2	Homo sapiens	34-76
35225679-2	2022	In sub-Saharan West African (WA) Blacks, some nonancestral alleles of iron-related genes HJV, SLC40A1, and TFR2 are common, whereas in European Americans (EA) the same alleles are rare.	Iron	70-74	transferrin receptor 2	Homo sapiens	107-111
26318828-5	2015	Instead, previous work suggests that regulation of iron metabolism could represent an important mechanism of NGAL action, with wide-ranging consequences spanning metabolic and cardiovascular diseases to host defence against bacterial infection.	Iron	51-55	lipocalin 2	Homo sapiens	109-113
35204159-2	2022	HO-1 and its end products, biliverdin, carbon monoxide and free iron (Fe2+), confer cytoprotection against inflammatory and oxidative injury.	Iron	64-68	heme oxygenase 1	Homo sapiens	0-4
26318828-7	2015	In particular, we focus on iron transport as a mechanism of NGAL action and discuss this in the context of the existing strong associations between iron overload and iron deficiency with cardiomyopathy.	Iron	27-31	lipocalin 2	Homo sapiens	60-64
26318828-7	2015	In particular, we focus on iron transport as a mechanism of NGAL action and discuss this in the context of the existing strong associations between iron overload and iron deficiency with cardiomyopathy.	Iron	148-152	lipocalin 2	Homo sapiens	60-64
25788528-0	2015	Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	0-8
25788528-2	2015	Hepcidin is an endogenous acute phase hepatic hormone that prevents iron export from cells by inducing degradation of the only known iron export protein, ferroportin.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
35118074-4	2021	We identified the prognostic value of two iron metabolism-related genes (SLC39A8 (encoding solute carrier family 39 member 8) and SLC48A1 (encoding solute carrier family 48 member 1)) in COAD.	Iron	42-46	solute carrier family 48 member 1	Homo sapiens	130-137
25788528-2	2015	Hepcidin is an endogenous acute phase hepatic hormone that prevents iron export from cells by inducing degradation of the only known iron export protein, ferroportin.	Iron	133-137	hepcidin antimicrobial peptide	Mus musculus	0-8
25788528-3	2015	In this study, we used a mouse model to investigate the effect of renal ischemia-reperfusion injury on systemic iron homeostasis and determine if dynamic modulation of iron homeostasis with hepcidin has therapeutic benefit in the treatment of AKI.	Iron	168-172	hepcidin antimicrobial peptide	Mus musculus	190-198
25788528-5	2015	Exogenous hepcidin treatment prevented renal ischemia-reperfusion-induced changes in iron homeostasis.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	10-18
25788528-7	2015	Hepcidin-induced restoration of iron homeostasis was accompanied by a significant reduction in ischemia-reperfusion-induced tubular injury, apoptosis, renal oxidative stress, and inflammatory cell infiltration.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	0-8
25788528-9	2015	Reconstituting hepcidin-deficient mice with exogenous hepcidin induced hepatic iron sequestration, attenuated the reduction in renal H-ferritin and reduced renal oxidative stress, apoptosis, inflammation, and tubular injury.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	15-23
25788528-9	2015	Reconstituting hepcidin-deficient mice with exogenous hepcidin induced hepatic iron sequestration, attenuated the reduction in renal H-ferritin and reduced renal oxidative stress, apoptosis, inflammation, and tubular injury.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	54-62
35174317-13	2022	We propose that MYCN orchestrates both enhanced cystine uptake and enhanced activity of the transsulfuration pathway to counteract increased reactive oxygen species (ROS) from iron-induced Fenton reactions, ultimately contributing to a ferroptosis vulnerability in MYCN-amplified neuroblastoma.	Iron	176-180	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	16-20
25788528-12	2015	Hepcidin treatment restores iron homeostasis and reduces inflammation to mediate protection in renal ischemia-reperfusion injury, suggesting that hepcidin-ferroportin pathway holds promise as a novel therapeutic target in the treatment of AKI.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	0-8
25788528-12	2015	Hepcidin treatment restores iron homeostasis and reduces inflammation to mediate protection in renal ischemia-reperfusion injury, suggesting that hepcidin-ferroportin pathway holds promise as a novel therapeutic target in the treatment of AKI.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	146-154
35174317-13	2022	We propose that MYCN orchestrates both enhanced cystine uptake and enhanced activity of the transsulfuration pathway to counteract increased reactive oxygen species (ROS) from iron-induced Fenton reactions, ultimately contributing to a ferroptosis vulnerability in MYCN-amplified neuroblastoma.	Iron	176-180	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	265-269
26475181-7	2015	Dietary Pi regulated the messenger RNA expression of iron-regulated genes, including divalent metal transporter 1, duodenal cytochrome B, and hepcidin.	Iron	53-57	RoBo-1	Rattus norvegicus	85-113
35124772-3	2021	Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1.	Iron	110-114	solute carrier family 40 member 1	Homo sapiens	14-18
2548600-6	1989	These results clearly indicate that the Fe coordination in CCP and its mutants is sensitive to both temperature and solvent composition.	Iron	40-42	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	59-62
26508587-4	2015	Here we experimentally demonstrate ultrafast coherent spin precession via optical charge-transfer processes in the exchange-coupled Fe/CoO system at room temperature.	Iron	132-134	spindlin 1	Homo sapiens	54-58
26506412-11	2015	These results suggest that the genetic ablation of iPLA2beta increased iron uptake in the brain through the activation of IRP2 and upregulation of DMT1, which may be associated with mitochondrial dysfunction.	Iron	71-75	iron responsive element binding protein 2	Mus musculus	122-126
26489858-5	2015	The colloidal stability and redox chemistry of the most and least toxic CNPs, CNP1 and CNP2, respectively, were modified by incubation with iron and phosphate buffers.	Iron	140-144	natriuretic peptide C	Homo sapiens	87-91
26289753-7	2015	Preincubation with the antioxidant N-acetyl-l-cysteine (NAC) resulted in increased DMT1 at the apical membrane before and after addition of iron.	Iron	140-144	X-linked Kx blood group	Homo sapiens	56-59
26407034-0	2015	Size-Specific Spin Configurations in Single Iron Nanomagnet: From Flower to Exotic Vortices.	Iron	44-48	spindlin 1	Homo sapiens	14-18
26248693-0	2015	Spin Crossover and Valence Tautomerism in Neutral Homoleptic Iron Complexes of Bis(pyridylimino)isoindolines.	Iron	61-65	spindlin 1	Homo sapiens	0-4
26333417-0	2015	Antiferromagnetic Spin Coupling between Rare Earth Adatoms and Iron Islands Probed by Spin-Polarized Tunneling.	Iron	63-67	spindlin 1	Homo sapiens	18-22
26333417-0	2015	Antiferromagnetic Spin Coupling between Rare Earth Adatoms and Iron Islands Probed by Spin-Polarized Tunneling.	Iron	63-67	spindlin 1	Homo sapiens	86-90
26333417-5	2015	The spin-polarized current indicates that both kind of adatoms have in-plane magnetic moments, which couple antiferromagnetically with their underlying iron islands.	Iron	152-156	spindlin 1	Homo sapiens	4-8
26458496-1	2015	Transferrin receptor 2 (Tfr2) is an iron-modulator transcribed in two isoforms, Tfr2alpha and Tfr2beta.	Iron	36-40	transferrin receptor 2	Mus musculus	0-22
26458496-1	2015	Transferrin receptor 2 (Tfr2) is an iron-modulator transcribed in two isoforms, Tfr2alpha and Tfr2beta.	Iron	36-40	transferrin receptor 2	Mus musculus	24-28
26464252-0	2015	Influence of Iron Supplementation on DMT1 (IRE)-induced Transport of Lead by Brain Barrier Systems in vivo.	Iron	13-17	RoBo-1	Rattus norvegicus	37-41
26033030-3	2015	To address this issue, a sensitive ferrozine-based detection system for intracellular iron removal from the human hepatocyte cell line (HuH-7) was developed.	Iron	86-90	MIR7-3 host gene	Homo sapiens	136-141
25541674-13	2015	Conclusions Hp2-2 genotype is a significant predictor for premature atherosclerosis in TM children and confers them an increased risk for iron overload.	Iron	138-142	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	12-17
26136265-2	2015	Expression of two iron SODs, FSD2 and FSD3, was significantly increased in Arabidopsis in response to NaCl treatment but blocked in transgenic MKK5-RNAi plant, mkk5.	Iron	18-22	MAP kinase kinase 5	Arabidopsis thaliana	143-147
26136265-2	2015	Expression of two iron SODs, FSD2 and FSD3, was significantly increased in Arabidopsis in response to NaCl treatment but blocked in transgenic MKK5-RNAi plant, mkk5.	Iron	18-22	MAP kinase kinase 5	Arabidopsis thaliana	160-164
25447222-13	2015	Rotarod test revealed a progressive impaired motor coordination building up with age, FTL mutant old mice showing a shorter latency to fall from the apparatus, according to higher accumulation of iron aggregates in the striatum.	Iron	196-200	ferritin light polypeptide 1	Mus musculus	86-89
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	99-103	aconitase 1	Mus musculus	0-32
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	99-103	aconitase 1	Mus musculus	34-38
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	99-103	iron responsive element binding protein 2	Mus musculus	43-47
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	154-158	aconitase 1	Mus musculus	0-32
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	154-158	aconitase 1	Mus musculus	34-38
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	154-158	iron responsive element binding protein 2	Mus musculus	43-47
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	154-158	aconitase 1	Mus musculus	0-32
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	154-158	aconitase 1	Mus musculus	34-38
25771171-1	2015	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.	Iron	154-158	iron responsive element binding protein 2	Mus musculus	43-47
25771171-5	2015	Irp1(-/-) mice develop polycythemia and pulmonary hypertension, and when these mice are challenged with a low iron diet, they die early of abdominal hemorrhages, suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.	Iron	110-114	aconitase 1	Mus musculus	178-182
26371671-1	2015	We investigate the origin of the spin Seebeck effect in yttrium iron garnet (YIG) samples for film thicknesses from 20 nm to 50  mum at room temperature and 50 K. Our results reveal a characteristic increase of the longitudinal spin Seebeck effect amplitude with the thickness of the insulating ferrimagnetic YIG, which levels off at a critical thickness that increases with decreasing temperature.	Iron	64-68	spindlin 1	Homo sapiens	33-37
26371671-1	2015	We investigate the origin of the spin Seebeck effect in yttrium iron garnet (YIG) samples for film thicknesses from 20 nm to 50  mum at room temperature and 50 K. Our results reveal a characteristic increase of the longitudinal spin Seebeck effect amplitude with the thickness of the insulating ferrimagnetic YIG, which levels off at a critical thickness that increases with decreasing temperature.	Iron	64-68	spindlin 1	Homo sapiens	228-232
26112383-5	2015	This study aims to investigate the effects of SFN on memory deficits and changes in markers of mitochondrial function, DNM1L and OPA1, and the synaptic marker, synaptophysin, induced by neonatal iron treatment.	Iron	195-199	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	129-133
26112383-5	2015	This study aims to investigate the effects of SFN on memory deficits and changes in markers of mitochondrial function, DNM1L and OPA1, and the synaptic marker, synaptophysin, induced by neonatal iron treatment.	Iron	195-199	synaptophysin	Rattus norvegicus	160-173
26112383-10	2015	Results showed that SFN was able to reverse iron-induced decreases in mitochondrial fission protein, DNM1L, as well as synaptophysin levels in the hippocampus, leading to a recovery of recognition memory impairment induced by iron.	Iron	44-48	dynamin 1-like	Rattus norvegicus	101-106
26112383-10	2015	Results showed that SFN was able to reverse iron-induced decreases in mitochondrial fission protein, DNM1L, as well as synaptophysin levels in the hippocampus, leading to a recovery of recognition memory impairment induced by iron.	Iron	44-48	synaptophysin	Rattus norvegicus	119-132
26278134-0	2015	Quantitative analysis of magnetic spin and orbital moments from an oxidized iron (1 1 0) surface using electron magnetic circular dichroism.	Iron	76-80	spindlin 1	Homo sapiens	34-38
25912790-0	2015	The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity.	Iron	71-75	ATPase cation transporting 13A2	Homo sapiens	42-49
25912790-4	2015	Loss-of-function mutations in the ATP13A2 gene (PARK9, OMIM 610513) underlay a form of Parkinson"s disease (PD) known as the Kufor-Rakeb syndrome (KRS), which belongs to the group of syndromes of neurodegeneration with brain iron accumulation (NBIA).	Iron	225-229	ATPase cation transporting 13A2	Homo sapiens	34-41
25912790-4	2015	Loss-of-function mutations in the ATP13A2 gene (PARK9, OMIM 610513) underlay a form of Parkinson"s disease (PD) known as the Kufor-Rakeb syndrome (KRS), which belongs to the group of syndromes of neurodegeneration with brain iron accumulation (NBIA).	Iron	225-229	ATPase cation transporting 13A2	Homo sapiens	48-53
25912790-6	2015	Moreover, the iron content in ATP13A2 cells was lower than control cells stably expressing an inactive mutant of ATP13A2.	Iron	14-18	ATPase cation transporting 13A2	Homo sapiens	30-37
25912790-6	2015	Moreover, the iron content in ATP13A2 cells was lower than control cells stably expressing an inactive mutant of ATP13A2.	Iron	14-18	ATPase cation transporting 13A2	Homo sapiens	113-120
25912790-8	2015	ATP13A2 cells exhibited a reduced iron-induced lysosome membrane permeabilization (LMP).	Iron	34-38	ATPase cation transporting 13A2	Homo sapiens	0-7
25912790-9	2015	These results suggest that ATP13A2 overexpression improves the lysosome membrane integrity and protects against the iron-induced cell damage.	Iron	116-120	ATPase cation transporting 13A2	Homo sapiens	27-34
25982934-2	2015	Fes, IroD and IroE esterases degrade salmochelins and enterobactin to release iron.	Iron	78-82	IroD	Escherichia coli	5-9
26159707-1	2015	Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens.	Iron	65-69	lipocalin 2	Homo sapiens	0-11
26159707-1	2015	Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens.	Iron	65-69	lipocalin 2	Homo sapiens	13-17
26159707-1	2015	Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens.	Iron	136-140	lipocalin 2	Homo sapiens	0-11
26159707-1	2015	Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens.	Iron	136-140	lipocalin 2	Homo sapiens	13-17
26159707-2	2015	The recent identification of a mammalian siderophore also suggests a physiological role for LCN2 in iron homeostasis, specifically in iron delivery to cells via a transferrin-independent mechanism.	Iron	100-104	lipocalin 2	Homo sapiens	92-96
26159707-2	2015	The recent identification of a mammalian siderophore also suggests a physiological role for LCN2 in iron homeostasis, specifically in iron delivery to cells via a transferrin-independent mechanism.	Iron	134-138	lipocalin 2	Homo sapiens	92-96
26135639-0	2015	A Terminal N2 Complex of High-Spin Iron(I) in a Weak, Trigonal Ligand Field.	Iron	35-39	spindlin 1	Homo sapiens	30-34
26135639-3	2015	Given that the nitrogenase active site uses weak-field sulfide ligands to stabilize its reactive Fe center(s), N2 binding to high-spin Fe is of great interest.	Iron	97-99	spindlin 1	Homo sapiens	130-134
26135639-3	2015	Given that the nitrogenase active site uses weak-field sulfide ligands to stabilize its reactive Fe center(s), N2 binding to high-spin Fe is of great interest.	Iron	135-137	spindlin 1	Homo sapiens	130-134
26016389-6	2015	Similar reactions that included the apo Fe-S acceptor protein human ferredoxin (FDX1) resulted in formation of [2Fe-2S]-ISCU2 rather than [2Fe-2S]-FDX1.	Iron	40-44	ferredoxin 1	Homo sapiens	80-84
26016389-6	2015	Similar reactions that included the apo Fe-S acceptor protein human ferredoxin (FDX1) resulted in formation of [2Fe-2S]-ISCU2 rather than [2Fe-2S]-FDX1.	Iron	40-44	ferredoxin 1	Homo sapiens	147-151
25875786-7	2015	Among all ten proteins associated with LCN2; highest confidence of prediction were seen for the associations between LCN2 and metalloproteinase 9 (MMP9) and lipoprotein receptor-related protein 2 (LRP2) which play vital roles in tumor growth and iron transportation, respectively.	Iron	246-250	LDL receptor related protein 2	Gallus gallus	157-195
25875786-7	2015	Among all ten proteins associated with LCN2; highest confidence of prediction were seen for the associations between LCN2 and metalloproteinase 9 (MMP9) and lipoprotein receptor-related protein 2 (LRP2) which play vital roles in tumor growth and iron transportation, respectively.	Iron	246-250	LDL receptor related protein 2	Gallus gallus	197-201
25447545-3	2015	The Suf (sulfur formation) system is the most ancient of the three characterized Fe-S cluster biogenesis pathways, which also include the Isc and Nif systems.	Iron	81-83	S100 calcium binding protein A9	Homo sapiens	146-149
25663418-2	2015	Also known as the hpx mouse, this line is almost completely devoid of transferrin, an abundant serum iron-binding protein.	Iron	101-105	transferrin	Mus musculus	70-81
25663418-4	2015	These phenotypes reflect the essential role of transferrin in iron delivery to bone marrow and regulation of iron homeostasis.	Iron	62-66	transferrin	Mus musculus	47-58
25663418-4	2015	These phenotypes reflect the essential role of transferrin in iron delivery to bone marrow and regulation of iron homeostasis.	Iron	109-113	transferrin	Mus musculus	47-58
25825391-3	2015	In pulmonary vascular cells and particularly endothelium, hypoxic induction of miR-210 and repression of the miR-210 targets ISCU1/2 down-regulated Fe-S levels.	Iron	148-152	iron-sulfur cluster assembly enzyme	Mus musculus	125-132
25568302-1	2015	The anaemia of chronic disease (ACD) results from inflammation-mediated up-regulation of the iron regulatory hormone hepcidin, with the consequent sequestration of iron limiting its availability for erythropoiesis.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	117-125
25568302-1	2015	The anaemia of chronic disease (ACD) results from inflammation-mediated up-regulation of the iron regulatory hormone hepcidin, with the consequent sequestration of iron limiting its availability for erythropoiesis.	Iron	164-168	hepcidin antimicrobial peptide	Mus musculus	117-125
25568302-6	2015	In the absence of IL-22, there was a response of hepcidin, resulting in a reduction in serum iron levels.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	49-57
25996596-12	2015	This amino acid position 141 is unique in Isu1, and the frataxin-bypass effect likely mimics a conserved and ancient feature of the prokaryotic Fe-S cluster assembly machinery.	Iron	144-148	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	42-46
25608116-5	2015	RESULTS: Hfe(-/-)Hjv(-/-) mice developed iron overload in multiple organs at levels comparable to Hjv(-/-) mice.	Iron	41-45	homeostatic iron regulator	Mus musculus	9-12
25608116-5	2015	RESULTS: Hfe(-/-)Hjv(-/-) mice developed iron overload in multiple organs at levels comparable to Hjv(-/-) mice.	Iron	41-45	hemojuvelin BMP co-receptor	Mus musculus	17-20
25608116-6	2015	After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	51-59
25608116-6	2015	After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	67-72
25608116-6	2015	After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice.	Iron	27-31	homeostatic iron regulator	Mus musculus	124-127
25608116-6	2015	After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice.	Iron	27-31	homeostatic iron regulator	Mus musculus	169-172
25608116-6	2015	After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice.	Iron	27-31	hemojuvelin BMP co-receptor	Mus musculus	177-180
26136767-1	2015	Mutations in C19orf12 have been identified in patients affected by Neurodegeneration with Brain Iron Accumulation (NBIA), a clinical entity characterized by iron accumulation in the basal ganglia.	Iron	96-100	chromosome 19 open reading frame 12	Homo sapiens	13-21
26136767-1	2015	Mutations in C19orf12 have been identified in patients affected by Neurodegeneration with Brain Iron Accumulation (NBIA), a clinical entity characterized by iron accumulation in the basal ganglia.	Iron	157-161	chromosome 19 open reading frame 12	Homo sapiens	13-21
25839654-1	2015	Hepcidin is a peptide hormone secreted in the liver and plays a key role in maintaining iron homeostasis.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	0-8
25839654-8	2015	Overall, our current study provides a novel molecular mechanism of BTG2-mediated induction of hepcidin gene expression, thereby contributing to a better understanding of the hepatic hepcidin production involved in iron homeostasis.	Iron	214-218	hepcidin antimicrobial peptide	Mus musculus	94-102
25839654-8	2015	Overall, our current study provides a novel molecular mechanism of BTG2-mediated induction of hepcidin gene expression, thereby contributing to a better understanding of the hepatic hepcidin production involved in iron homeostasis.	Iron	214-218	hepcidin antimicrobial peptide	Mus musculus	182-190
25859818-1	2015	Spin-resolved scanning tunneling microscopy is used to reveal a commensurate hexagonal nanoskyrmion lattice in the hcp stacked Fe monolayer on Ir(111).	Iron	127-129	spindlin 1	Homo sapiens	0-4
25859818-2	2015	The exact nature of the spin configuration is due to magnetic interactions between the Fe atoms and the Ir substrate, either originating from polarization effects, or due to a three-site hopping mechanism of the Dzyaloshinsky-Moriya interaction leading to a canting of the Dzyaloshinsky-Moriya vector with respect to the interface.	Iron	87-89	spindlin 1	Homo sapiens	24-28
25867032-1	2015	Addition of Co2(Co)9 and Ru3(CO)12 on preformed monodisperse iron(0) nanoparticles (Fe(0) NPs) at 150  C under H2 leads to monodisperse core-shell Fe@FeCo NPs and to a thin discontinuous Ru(0) layer supported on the initial Fe(0) NPs.	Iron	61-65	phosphoserine phosphatase pseudogene 1	Homo sapiens	12-20
25867032-1	2015	Addition of Co2(Co)9 and Ru3(CO)12 on preformed monodisperse iron(0) nanoparticles (Fe(0) NPs) at 150  C under H2 leads to monodisperse core-shell Fe@FeCo NPs and to a thin discontinuous Ru(0) layer supported on the initial Fe(0) NPs.	Iron	84-86	phosphoserine phosphatase pseudogene 1	Homo sapiens	12-20
25867032-1	2015	Addition of Co2(Co)9 and Ru3(CO)12 on preformed monodisperse iron(0) nanoparticles (Fe(0) NPs) at 150  C under H2 leads to monodisperse core-shell Fe@FeCo NPs and to a thin discontinuous Ru(0) layer supported on the initial Fe(0) NPs.	Iron	147-149	phosphoserine phosphatase pseudogene 1	Homo sapiens	12-20
25178559-3	2015	High concentrations of GDF-15 have been found in some haemoglobinopathies associated with suppressed concentration of hepcidin and iron overload.	Iron	131-135	growth differentiation factor 15	Homo sapiens	23-29
25600403-8	2015	We also observed an increase in iron uptake and a decrease in transferrin receptor protein upon TXNIP overexpression, suggesting a role in iron homeostasis.	Iron	139-143	transferrin	Mus musculus	62-73
25609138-0	2015	Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.	Iron	46-50	homeostatic iron regulator	Mus musculus	0-3
25609138-0	2015	Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.	Iron	46-50	hemojuvelin BMP co-receptor	Mus musculus	8-11
25609138-0	2015	Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	64-72
25609138-2	2015	Systemic iron overload results from inadequate expression of hepcidin, the iron regulatory hormone.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	61-69
25609138-7	2015	As expected, Hfe (-)/(-) and Hjv (-)/(-) mice developed relatively mild or severe iron overload, respectively, which corresponded to the degree of hepcidin inhibition.	Iron	82-86	homeostatic iron regulator	Mus musculus	13-16
25609138-7	2015	As expected, Hfe (-)/(-) and Hjv (-)/(-) mice developed relatively mild or severe iron overload, respectively, which corresponded to the degree of hepcidin inhibition.	Iron	82-86	hemojuvelin BMP co-receptor	Mus musculus	29-32
25609138-8	2015	The double Hfe (-)/(-) Hjv (-)/(-) mice exhibited an indistinguishable phenotype to single Hjv (-)/(-) counterparts with regard to suppression of hepcidin, serum and hepatic iron overload, splenic iron deficiency, tissue iron metabolism, and Smad signaling, under both dietary regimens.	Iron	174-178	homeostatic iron regulator	Mus musculus	11-14
25609138-8	2015	The double Hfe (-)/(-) Hjv (-)/(-) mice exhibited an indistinguishable phenotype to single Hjv (-)/(-) counterparts with regard to suppression of hepcidin, serum and hepatic iron overload, splenic iron deficiency, tissue iron metabolism, and Smad signaling, under both dietary regimens.	Iron	197-201	homeostatic iron regulator	Mus musculus	11-14
25609138-10	2015	Our results provide genetic evidence that Hfe and Hjv operate in the same pathway for the regulation of hepcidin expression and iron metabolism.	Iron	128-132	homeostatic iron regulator	Mus musculus	42-45
25609138-10	2015	Our results provide genetic evidence that Hfe and Hjv operate in the same pathway for the regulation of hepcidin expression and iron metabolism.	Iron	128-132	hemojuvelin BMP co-receptor	Mus musculus	50-53
25627251-7	2015	KEY FINDINGS: CM1 possesses high affinity and selectivity for iron(III) and a suitable partition coefficient to permeate membranes.	Iron	62-66	Cardiac mass QTL 1	Rattus norvegicus	14-17
25627251-8	2015	CM1 forms a neutral 3 : 1 iron(III) complex under physiological conditions and so, it is predicted to be capable of entry into mammalian cells to scavenge excess intracellular iron and to efflux from cells as the neutral 3 : 1 complex.	Iron	26-30	Cardiac mass QTL 1	Rattus norvegicus	0-3
25923075-2	2015	In Arabidopsis thaliana, the Fe2+ transporter, iron (Fe)-regulated transporter1 (IRT1), mediates Fe uptake and also implicates in Ni2+ uptake at roots; however, the underlying mechanism of Ni2+ uptake and accumulation remains unelucidated.	Iron	47-51	iron-regulated transporter 1	Arabidopsis thaliana	81-85
25923075-2	2015	In Arabidopsis thaliana, the Fe2+ transporter, iron (Fe)-regulated transporter1 (IRT1), mediates Fe uptake and also implicates in Ni2+ uptake at roots; however, the underlying mechanism of Ni2+ uptake and accumulation remains unelucidated.	Iron	29-31	iron-regulated transporter 1	Arabidopsis thaliana	81-85
25941530-0	2015	Arbuscular mycorrhizal symbiosis alters the expression patterns of three key iron homeostasis genes, ZmNAS1, ZmNAS3, and ZmYS1, in S deprived maize plants.	Iron	77-81	nicotianamine synthase 1	Zea mays	101-107
25880808-1	2015	Abnormally low CD8+ T-lymphocyte numbers is characteristic of some patients with hereditary hemochromatosis (HH), a MHC-linked disorder of iron overload.	Iron	139-143	CD8a molecule	Homo sapiens	15-18
25880808-8	2015	We found an increased expression of S100a8 and S100a9 that is most pronounced in high iron diet conditions.	Iron	86-90	S100 calcium binding protein A9	Homo sapiens	47-53
26263154-0	2015	Determination of Spin Inversion Probability, H-Tunneling Correction, and Regioselectivity in the Two-State Reactivity of Nonheme Iron(IV)-Oxo Complexes.	Iron	129-133	spindlin 1	Homo sapiens	17-21
25860887-1	2015	Bmp6 is the main activator of hepcidin, the liver hormone that negatively regulates plasma iron influx by degrading the sole iron exporter ferroportin in enterocytes and macrophages.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	30-38
25860887-1	2015	Bmp6 is the main activator of hepcidin, the liver hormone that negatively regulates plasma iron influx by degrading the sole iron exporter ferroportin in enterocytes and macrophages.	Iron	125-129	hepcidin antimicrobial peptide	Mus musculus	30-38
25860887-6	2015	When hepcidin expression is abnormal in murine models of iron overload (Hjv KO mice) and deficiency (Tmprss6 KO mice), Bmp6 expression in NPCs was not related to Tfr1.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	5-13
25659899-7	2015	Thus, a reversal of factors increasing mitochondrial superoxide and oxidant effects that potentially influence remodeling signaling related to miR204 expression and perhaps iron availability needed for the biosynthesis of heme by the ferrochelatase reaction could be factors in the beneficial actions of ALA in pulmonary hypertension.	Iron	173-177	ferrochelatase	Mus musculus	234-248
25501899-4	2015	Iron accumulation mediated by divalent metal transporter 1 (DMT1) plays a key role in N-methyl-D-aspartate neurotoxicity.	Iron	0-4	RoBo-1	Rattus norvegicus	30-58
25501899-4	2015	Iron accumulation mediated by divalent metal transporter 1 (DMT1) plays a key role in N-methyl-D-aspartate neurotoxicity.	Iron	0-4	RoBo-1	Rattus norvegicus	60-64
25501899-5	2015	This study aims to determine whether peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via DMT1-mediated iron accumulation.	Iron	132-136	RoBo-1	Rattus norvegicus	118-122
25501899-13	2015	CONCLUSIONS: Our study identifies that spinal peroxynitrite activates DMT1(-)IRE, leading to abnormal iron accumulation in remifentanil-induced postoperative hyperalgesia, while providing the rationale for the development of molecular hydrogen and "iron-targeted" therapies.	Iron	102-106	RoBo-1	Rattus norvegicus	70-74
25501899-13	2015	CONCLUSIONS: Our study identifies that spinal peroxynitrite activates DMT1(-)IRE, leading to abnormal iron accumulation in remifentanil-induced postoperative hyperalgesia, while providing the rationale for the development of molecular hydrogen and "iron-targeted" therapies.	Iron	249-253	RoBo-1	Rattus norvegicus	70-74
25059214-4	2015	We recently found that hepcidin can increase intracellular iron and calcium levels and promote mineralization in osteoblasts.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	23-31
25711814-0	2015	OsSEC24, a functional SEC24-like protein in rice, improves tolerance to iron deficiency and high pH by enhancing H(+) secretion mediated by PM-H(+)-ATPase.	Iron	72-76	COPII subunit SEC24	Saccharomyces cerevisiae S288C	2-7
25890235-4	2015	Using neutrophils isolated from the knock-in mice, we identified several PKCdelta substrates, one of which was lipocalin-2 (LCN2), which is an iron-binding protein that can trigger apoptosis by reducing intracellular iron concentrations.	Iron	217-221	protein kinase C, delta	Mus musculus	73-81
25664924-3	2015	We measure the spin excitations of individual Fe atoms on a copper nitride surface with inelastic electron tunneling spectroscopy.	Iron	46-48	spindlin 1	Homo sapiens	15-19
25664924-5	2015	We quantitatively determine the three-dimensional distribution of the magnetic anisotropy of single Fe atoms by fitting the spin excitation spectra with a spin Hamiltonian.	Iron	100-102	spindlin 1	Homo sapiens	124-128
25664924-5	2015	We quantitatively determine the three-dimensional distribution of the magnetic anisotropy of single Fe atoms by fitting the spin excitation spectra with a spin Hamiltonian.	Iron	100-102	spindlin 1	Homo sapiens	155-159
25751021-2	2015	Here we show that elevated mtDNA mutagenesis in mice with a proof-reading deficient mtDNA polymerase (PolG) leads to incomplete mitochondrial clearance, with asynchronized iron loading in erythroid precursors, and increased total and free cellular iron content.	Iron	172-176	polymerase (DNA directed), gamma	Mus musculus	102-106
25249071-8	2015	This work also shows that the DNA-binding capability of endonuclease III is highly dependent of the nuclearity of the endogenous iron-sulfur cluster.	Iron	129-133	endonuclease III	Escherichia coli	56-72
25601767-0	2015	Spin-glass behavior of a hierarchically-organized, hybrid microporous material, based on an extended framework of octanuclear iron-oxo units.	Iron	126-130	spindlin 1	Homo sapiens	0-4
25601767-5	2015	(57)Fe-Mossbauer spectroscopic analysis provides insights to the intercluster connectivity of and on one hand and to their magnetic properties on the other, evident by a magnetic split sextet below 30 K. The combination of Mossbauer spectroscopy and magnetism measurements reveals a spin-glass behavior with Tg of ~30 K. The hierarchical porous materials and straddle the gap between metal oxides and metal-organic frameworks (MOFs).	Iron	4-6	spindlin 1	Homo sapiens	283-287
25260218-6	2015	A new, enigmatic protein entering the iron scene and affecting the macrophage phenotype is lipocalin-2.	Iron	38-42	lipocalin 2	Homo sapiens	91-102
25544697-1	2015	Transferrin binding protein A (TbpA), an iron acquisition surface protein that also acts as virulence factor, is widely distributed among strains of Pasteurella multocida.	Iron	41-45	transthyretin	Rattus norvegicus	31-35
25499025-5	2015	These include the expanding protein network involved in FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR (FIT)-dependent gene regulation and novel findings on the intracellular trafficking of the Fe transporter IRON-REGULATED TRANSPORTER 1 (IRT1).	Iron	65-69	iron-regulated transporter 1	Arabidopsis thaliana	216-244
25499025-5	2015	These include the expanding protein network involved in FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR (FIT)-dependent gene regulation and novel findings on the intracellular trafficking of the Fe transporter IRON-REGULATED TRANSPORTER 1 (IRT1).	Iron	65-69	iron-regulated transporter 1	Arabidopsis thaliana	246-250
25471216-0	2015	Long-chain n-3 PUFA supplementation decreases physical activity during class time in iron-deficient South African school children.	Iron	85-89	pumilio RNA binding family member 3	Homo sapiens	15-19
25629408-4	2015	In humans, homozygous loss of the L gene (FTL) is associated with generalized seizure and atypical restless leg syndrome, while mutations in FTL cause a form of neurodegeneration with brain iron accumulation.	Iron	190-194	ferritin light chain	Homo sapiens	141-144
25478817-5	2015	The power of this approach is highlighted with an extreme example in which the kinetics of Fe-S cluster transfer reactions are monitored between two Fdx molecules that have identical Fe-S spectroscopic properties.	Iron	91-95	ferredoxin 1	Homo sapiens	149-152
25478817-5	2015	The power of this approach is highlighted with an extreme example in which the kinetics of Fe-S cluster transfer reactions are monitored between two Fdx molecules that have identical Fe-S spectroscopic properties.	Iron	183-187	ferredoxin 1	Homo sapiens	149-152
28962376-13	2015	In conclusion, we demonstrate furin downregulation in conjunction with Hamp1 mRNA-unrelated pattern of hepcidin protein expression in iron-overloaded mice, particularly the WT mice, suggesting that, not only the amount of hepcidin but also the furin-mediated physiological activity may be decreased in severe iron overload condition.	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	222-230
25371212-12	2015	Model fitting required that the first species, assigned to non-transferrin-bound iron, imports faster into organs than the second, assigned to transferrin-bound-iron.	Iron	81-85	transferrin	Mus musculus	63-74
25371212-12	2015	Model fitting required that the first species, assigned to non-transferrin-bound iron, imports faster into organs than the second, assigned to transferrin-bound-iron.	Iron	161-165	transferrin	Mus musculus	143-154
25371212-13	2015	Non-transferrin-bound iron rather than transferrin-bound-iron appears to play the dominant role in importing iron into organs during early development of healthy mice.	Iron	22-26	transferrin	Mus musculus	4-15
25236856-6	2015	Bone marrow erythroid progenitors from erythropoietin-treated mice exhibited iron-restricted erythropoiesis, as indicated by increased median fluorescence intensity of transferrin receptor immunostaining by flow cytometry.	Iron	77-81	transferrin	Mus musculus	168-179
25444857-1	2015	Cysteine dioxygenase (CDO) is a non-heme mononuclear iron enzyme that catalyzes the oxygen-dependent oxidation of L-cysteine (Cys) to produce L-cysteine sulfinic acid (CSA).	Iron	53-57	cysteine dioxygenase 1, cytosolic	Mus musculus	0-20
25444857-1	2015	Cysteine dioxygenase (CDO) is a non-heme mononuclear iron enzyme that catalyzes the oxygen-dependent oxidation of L-cysteine (Cys) to produce L-cysteine sulfinic acid (CSA).	Iron	53-57	cysteine dioxygenase 1, cytosolic	Mus musculus	22-25
25444857-2	2015	Sequence alignment of mammalian CDO with recently discovered thiol dioxygenase enzymes suggests that the mononuclear iron site within all enzymes in this class share a common 3-His first coordination sphere.	Iron	117-121	cysteine dioxygenase 1, cytosolic	Mus musculus	32-35
25460660-13	2015	Thus, our results indicated some adverse effects of children"s exposure to multiple metals, such as cognitive deficits and ALA-D inhibition, mainly associated to Mn, Fe, Cr and Hg.	Iron	166-168	aminolevulinate dehydratase	Homo sapiens	123-128
26118715-6	2015	The results showed that depletion of Mfrn1/2 in 3T3-L1 preadipocytes impaired the biosynthesis of iron-sulfur proteins in mitochondria due to a decrease in mitochondrial iron content.	Iron	98-102	solute carrier family 25 member 37	Homo sapiens	37-42
26118715-6	2015	The results showed that depletion of Mfrn1/2 in 3T3-L1 preadipocytes impaired the biosynthesis of iron-sulfur proteins in mitochondria due to a decrease in mitochondrial iron content.	Iron	170-174	solute carrier family 25 member 37	Homo sapiens	37-42
26118715-10	2015	These findings suggest that dysregulation of mitochondrial iron metabolism elicited by knockdown of Mfrn1/2 results in mitochondrial dysfunction, which culminates in the compromise of differentiation and insulin insensitivity of adipocytes.	Iron	59-63	solute carrier family 25 member 37	Homo sapiens	100-105
25300398-11	2015	Administration of exogenous BMP7 was effective in correcting the plasma iron level and bone loss, indicating that BMP6 is an essential but not exclusive in vivo regulator of iron homeostasis.	Iron	174-178	bone morphogenetic protein 7	Mus musculus	28-32
2500271-2	1989	In an epileptic boy undergoing long-term treatment with valproic acid (VPA), 1.3 g/d, CBMZP, 0.9 g/d and folic acid, 7.5 mg/d, decreased activities of ALA-D and URO-S coincided with increased levels of erythrocyte protoporphyrin (EP) in the absence of Pb poisoning, iron depletion and erythropoietic protoporphyria.	Iron	266-270	aminolevulinate dehydratase	Homo sapiens	151-156
2499359-16	1989	This provides an explanation why NADH:Q oxidoreductase was not able to oxidise NADPH at pH 8.0, while part of the Fe-S clusters were still rapidly reduced.	Iron	114-118	thioredoxin reductase 1	Homo sapiens	40-54
2499359-20	1989	A pH-dependent electron transfer from protomer A to protomer B is proposed, which would allow the reduction of Fe-S clusters 2 and 4 of protomer B by NADPH at pH 6.2, which is required for NADPH:Q oxidoreductase activity.	Iron	111-115	thioredoxin reductase 1	Homo sapiens	197-211
18964765-7	1989	The proposed method has been applied to determination of iron in tap water.	Iron	57-61	nuclear RNA export factor 1	Homo sapiens	65-68
2659611-2	1989	Four points are fundamental: copper is combined with essential enzymatic systems (oxidases, transaminases), copper is necessary for inclusion of iron in the molecule of hemoglobin, copper has a primordial role in the metabolism of molecule of hemoglobin, copper has a primordial role in the metabolism of collagen and elastin and some vascular diseases (aneurysms) are closely related to its lack, finally, there is an increase of plasmatic copper during cancerous diseases, which is significant even at an early time and usually proportional to the evolution.	Iron	145-149	elastin	Homo sapiens	318-325
2539809-0	1989	pH effects on the haem iron co-ordination state in the nitric oxide and deoxy derivatives of ferrous horseradish peroxidase and cytochrome c peroxidase.	Iron	23-27	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	128-151
2539809-4	1989	and absorption spectra of the NO and deoxy derivatives of HRP and CCP are typical of systems in which the haem iron is in the hexaco-ordinated state and the pentaco-ordinated state respectively.	Iron	111-115	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	66-69
2539809-8	1989	However, the slow second-order rate constant (0.003 microM-1.s-1) for CO binding to deoxy ferrous HRP and CCP does not increase substantially even at pH 2.6, suggesting that changes in the Fe-haem plane geometry, presumably associated with the cleavage of the Fe-N(epsilon) bond, do not affect appreciably the observed ligand association rate constant.	Iron	189-191	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	106-109
2914926-6	1989	The relaxation data for the paramagnetic system and the correlation time have been used to calculate a distance of 3.8 A between the heme iron and the C-9 fluoride.	Iron	138-142	complement C9	Homo sapiens	151-154
2806122-7	1989	Immunoprecipitation with a broad spectrum milk antiserum showed that more than 80% of caseins were secreted into the lumina, whereas iron-binding proteins (both lactoferrin and transferrin) were present in comparable amounts in each compartment.	Iron	133-137	transferrin	Mus musculus	177-188
2917363-3	1989	The cells in the nonparenchymal liver cell population responsible for IFN alpha/beta production were adherent, phagocytic, silica-sensitive, carbonyl-iron-sensitive, and Thy1.2-, presumably Kupffer cells or resident liver macrophages.	Iron	150-154	interferon alpha	Mus musculus	70-79
2852010-8	1988	Interestingly, haem-haemopexin serves as effectively as iron-transferrin as the sole source of iron for cell growth by Hepa cells.	Iron	56-60	transferrin	Mus musculus	61-72
3264289-3	1988	After single injections transferrin concentrations were not significantly changed, but the decrease in serum iron lowered mean transferrin saturations from a baseline of 45 to 24-30% in nonneutropenic mice, and from 99 to 70-77% in neutropenic mice.	Iron	109-113	transferrin	Mus musculus	127-138
3264289-6	1988	The combination of a decrease in serum iron and an increase in transferrin concentration after chronic infusion in neutropenic mice led to a greater decline in mean transferrin saturations, from a baseline of 110 to 25%.	Iron	39-43	transferrin	Mus musculus	165-176
2484545-7	1988	CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with ConA stimulation in presence of Zn or Fe.	Iron	115-117	CD8a molecule	Homo sapiens	4-7
26394828-5	2015	A relation between iron and FGF-23 metabolism is mentioned in a few studies.	Iron	19-23	fibroblast growth factor 23	Homo sapiens	28-34
3133394-6	1988	Because of the presence of Tf and F in oligodendrocytes it is suggested that these cells may play an important role in the metabolism of iron within the central nervous system.	Iron	137-141	transferrin	Mus musculus	27-29
26394828-6	2015	The aim of this study was to test the association of FGF-23 levels with echocardiographic (ECHO) and iron parameters in peritoneal dialysis patients (PD).	Iron	101-105	fibroblast growth factor 23	Homo sapiens	53-59
3421902-0	1988	Uptake and handling of iron from transferrin, lactoferrin and immune complexes by a macrophage cell line.	Iron	23-27	transferrin	Mus musculus	33-44
26257890-9	2015	Although catechol was a known NGAL-Siderocalin co-factor, our purification directly confirmed its presence in urine as well as its capacity to serve as an iron trap with NGAL-Siderocalin.	Iron	155-159	lipocalin 2	Homo sapiens	170-174
10037963-0	1988	Spin-wave nonlinear dynamics in an yttrium iron garnet sphere.	Iron	43-47	spindlin 1	Homo sapiens	0-4
25548482-18	2014	CONCLUSION: This study provides evidence that p62/IGF2BP2-2 drives the progression of NASH through elevation of hepatic iron deposition and increased production of hepatic free cholesterol.	Iron	120-124	nucleoporin 62	Mus musculus	46-49
25239763-3	2014	Here, we investigated the effects and underlying mechanisms of BDNF and GDNF on the iron influx process in primary cultured ventral mesencephalic neurons.	Iron	84-88	brain derived neurotrophic factor	Homo sapiens	63-67
25239763-4	2014	6-hydroxydopamine-induced enhanced ferrous iron influx via improper up-regulation of divalent metal transporter 1 with iron responsive element (DMT1+IRE) was consistently relieved by BDNF and GDNF.	Iron	43-47	brain derived neurotrophic factor	Homo sapiens	183-187
25239763-4	2014	6-hydroxydopamine-induced enhanced ferrous iron influx via improper up-regulation of divalent metal transporter 1 with iron responsive element (DMT1+IRE) was consistently relieved by BDNF and GDNF.	Iron	119-123	brain derived neurotrophic factor	Homo sapiens	183-187
25239763-9	2014	Taken together, these results show that BDNF and GDNF ameliorate iron accumulation via the ERK/Akt pathway, followed by inhibition of IRP1 and DMT1+IRE expression, which may provide new targets for the neuroprotective effects of these neurotrophic factors.	Iron	65-69	brain derived neurotrophic factor	Homo sapiens	40-44
2892838-4	1988	Posttranslational iron insertion into the apoproteins, either in vitro with membrane preparations or by iron addition during induction, results in the formation of active holoenzyme which can be reconstituted with NADH cytochrome b5 reductase and cytochrome b5 to form an active stearyl-CoA desaturase system.	Iron	18-22	cytochrome b5 type A	Rattus norvegicus	219-232
25193880-2	2014	The clathrin assembly lymphoid myeloid (CALM) protein plays an essential role in the cellular import of iron by clathrin-mediated endocytosis.	Iron	104-108	phosphatidylinositol binding clathrin assembly protein	Mus musculus	40-44
25193880-3	2014	CALM-AF10 leukemias harbor a single copy of the normal CALM gene and therefore may be more sensitive to the growth-inhibitory effect of iron restriction compared with normal hematopoietic cells.	Iron	136-140	phosphatidylinositol binding clathrin assembly protein	Mus musculus	0-4
2892838-4	1988	Posttranslational iron insertion into the apoproteins, either in vitro with membrane preparations or by iron addition during induction, results in the formation of active holoenzyme which can be reconstituted with NADH cytochrome b5 reductase and cytochrome b5 to form an active stearyl-CoA desaturase system.	Iron	18-22	cytochrome b5 type A	Rattus norvegicus	247-260
25193880-5	2014	CALM(HET) hematopoietic cells are more sensitive in vitro to iron chelators than their wild type counterparts.	Iron	61-65	phosphatidylinositol binding clathrin assembly protein	Mus musculus	0-4
25193880-6	2014	Iron chelation also displayed toxicity toward cultured CALM(HET)CALM-AF10 leukemia cells, and this effect was additive to that of chemotherapy.	Iron	0-4	phosphatidylinositol binding clathrin assembly protein	Mus musculus	55-59
2892838-4	1988	Posttranslational iron insertion into the apoproteins, either in vitro with membrane preparations or by iron addition during induction, results in the formation of active holoenzyme which can be reconstituted with NADH cytochrome b5 reductase and cytochrome b5 to form an active stearyl-CoA desaturase system.	Iron	104-108	cytochrome b5 type A	Rattus norvegicus	219-232
25193880-6	2014	Iron chelation also displayed toxicity toward cultured CALM(HET)CALM-AF10 leukemia cells, and this effect was additive to that of chemotherapy.	Iron	0-4	phosphatidylinositol binding clathrin assembly protein	Mus musculus	64-68
25193880-6	2014	Iron chelation also displayed toxicity toward cultured CALM(HET)CALM-AF10 leukemia cells, and this effect was additive to that of chemotherapy.	Iron	0-4	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10	Mus musculus	69-73
2892838-4	1988	Posttranslational iron insertion into the apoproteins, either in vitro with membrane preparations or by iron addition during induction, results in the formation of active holoenzyme which can be reconstituted with NADH cytochrome b5 reductase and cytochrome b5 to form an active stearyl-CoA desaturase system.	Iron	104-108	cytochrome b5 type A	Rattus norvegicus	247-260
25193880-9	2014	In summary, although CALM heterozygosity results in iron deficiency and increased sensitivity to iron chelation in vitro, our data in mice do not suggest that iron depletion strategies would be beneficial for the therapy of CALM-AF10 leukemia patients.	Iron	52-56	phosphatidylinositol binding clathrin assembly protein	Mus musculus	21-25
25193880-9	2014	In summary, although CALM heterozygosity results in iron deficiency and increased sensitivity to iron chelation in vitro, our data in mice do not suggest that iron depletion strategies would be beneficial for the therapy of CALM-AF10 leukemia patients.	Iron	97-101	phosphatidylinositol binding clathrin assembly protein	Mus musculus	21-25
2828121-0	1988	Iron-dependent hydroxyl radical formation and DNA damage from a novel metabolite of the clinically active antitumor drug VP-16.	Iron	0-4	host cell factor C1	Homo sapiens	121-126
24598129-3	2014	RESULTS: Exposure of subjects to hypoxia resulted in a significant decrease of serum levels of the master regulator of iron homeostasis hepcidin and elevated concentrations of platelet derived growth factor (PDGF)-BB.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	136-144
24598129-5	2014	We then exposed mice to hypoxia using a standardised chamber and observed downregulation of hepatic hepcidin mRNA expression that was paralleled by elevated serum PDGF-BB protein concentrations and higher serum iron levels as compared with mice housed under normoxic conditions.	Iron	211-215	hepcidin antimicrobial peptide	Mus musculus	100-108
2827651-3	1987	Furthermore, the EPR spectra of the heme-peptide and heme-HRG complexes were almost completely identical in pattern, showing signals characteristic of the low spin iron.	Iron	164-168	histidine rich glycoprotein	Homo sapiens	58-61
25385842-0	2014	Hyperinsulinemia induces hepatic iron overload by increasing liver TFR1 via the PI3K/IRP2 pathway.	Iron	33-37	iron responsive element binding protein 2	Rattus norvegicus	85-89
3435663-1	1987	The hypoferremic response in C57 black mice during EL4 lymphoma cell growth was followed to determine if a lowered transferrin iron saturation inhibited iron acquisition and growth by these tumor cells.	Iron	127-131	transferrin	Mus musculus	115-126
25400523-2	2014	The conventional mechanism for the dealkylation of N1-methyl adenine (1-meA) catalyzed by AlkB after the formation of FeIV-oxo is comprised by a reorientation of the oxo moiety, hydrogen abstraction, OH rebound from the Fe atom to the methyl adduct, and the dissociation of the resulting methoxide to obtain the repaired adenine base and formaldehyde.	Iron	118-120	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	90-94
3435663-1	1987	The hypoferremic response in C57 black mice during EL4 lymphoma cell growth was followed to determine if a lowered transferrin iron saturation inhibited iron acquisition and growth by these tumor cells.	Iron	153-157	transferrin	Mus musculus	115-126
25217696-5	2014	Normal hematopoietic cells showed elevated ROS levels through increased intracellular iron levels when treated with lipocalin-2, which led to p53 pathway activation, increased apoptosis, and decreased cellular proliferation.	Iron	86-90	lipocalin 2	Homo sapiens	116-127
3435663-7	1987	Thus the ability of the EL4 tumor cells to obtain iron appeared to exceed the ability of a vigorous murine hypoferremic response to sequester it, suggesting that the hypoferremic response does not effectively limit EL4 ascites tumor cell growth.	Iron	50-54	epilepsy 4	Mus musculus	24-27
3610230-0	1987	Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator.	Iron	106-110	transferrin	Mus musculus	15-26
24983770-1	2014	Ferritin light chain (FTL) reduces the free iron concentration by forming ferritin complexes with ferritin heavy chain (FTH).	Iron	44-48	ferritin light polypeptide 1	Mus musculus	0-20
24983770-1	2014	Ferritin light chain (FTL) reduces the free iron concentration by forming ferritin complexes with ferritin heavy chain (FTH).	Iron	44-48	ferritin light polypeptide 1	Mus musculus	22-25
24983770-1	2014	Ferritin light chain (FTL) reduces the free iron concentration by forming ferritin complexes with ferritin heavy chain (FTH).	Iron	44-48	ferritin heavy polypeptide 1	Mus musculus	98-118
24983770-1	2014	Ferritin light chain (FTL) reduces the free iron concentration by forming ferritin complexes with ferritin heavy chain (FTH).	Iron	44-48	ferritin heavy polypeptide 1	Mus musculus	120-123
3610230-2	1987	In the absence of transferrin, little proliferation occurred, but the response was restored by addition of the iron complex of pyridoxal isonicotinoyl hydrazone (FePIH), a lipophilic iron chelator.	Iron	111-115	transferrin	Mus musculus	18-29
3610230-3	1987	Since cellular acquisition of PIH-bound iron is known not to involve the transferrin receptor, these results indicate that transferrin promotes lymphocyte proliferation solely because of its iron-donating properties, and does not provide any additional signalling event for proliferation.	Iron	191-195	transferrin	Mus musculus	123-134
3028266-2	1987	The enzyme is a yellowish brown iron-sulfur protein, containing four nonheme iron and labile sulfide groups, that catalyzes the activation of NADP-malate dehydrogenase and fructose 1,6-bisphosphatase in the presence of ferredoxin and of thioredoxin m and f, respectively.	Iron	77-81	LOC101027257	Zea mays	237-248
25072389-7	2014	In this assay, NTBI is chelated by nitrilotriacetic acid (NTA), after which the iron is reduced and transferred to nitroso-PSAP, a chromogen.	Iron	80-84	prosaposin	Homo sapiens	123-127
25327288-6	2014	NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to autolysosomes following starvation or iron depletion.	Iron	65-69	ferritin heavy polypeptide 1	Mus musculus	21-43
25327288-6	2014	NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to autolysosomes following starvation or iron depletion.	Iron	65-69	ferritin heavy polypeptide 1	Mus musculus	45-49
25327288-6	2014	NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to autolysosomes following starvation or iron depletion.	Iron	178-182	ferritin heavy polypeptide 1	Mus musculus	21-43
3015885-1	1986	The aerobactin iron uptake system genes in the prototypic plasmid pColV-K30 are flanked by inverted copies of insertion sequence IS1 and by two distinct replication regions.	Iron	15-19	IS1	Homo sapiens	129-132
25327288-6	2014	NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to autolysosomes following starvation or iron depletion.	Iron	178-182	ferritin heavy polypeptide 1	Mus musculus	45-49
25228696-2	2014	The assembly process involves interaction of Isu with both Nfs1, the cysteine desulfurase serving as a sulfur donor, and the yeast frataxin homolog (Yfh1) serving as a regulator of desulfurase activity and/or iron donor.	Iron	209-213	ferroxidase	Saccharomyces cerevisiae S288C	149-153
3013876-6	1986	The uptake of iron from transferrin was limited by the level of endocytosis of transferrin during the initial phase of culture and the number of transferrin receptors at the cell surface during the latter stages of erythroid maturation of these cells.	Iron	14-18	transferrin	Mus musculus	24-35
25352340-4	2014	SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis.	Iron	35-39	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	8-13
25193872-2	2014	ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	61-69
25193872-2	2014	ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	61-69
3013876-6	1986	The uptake of iron from transferrin was limited by the level of endocytosis of transferrin during the initial phase of culture and the number of transferrin receptors at the cell surface during the latter stages of erythroid maturation of these cells.	Iron	14-18	transferrin	Mus musculus	79-90
3013876-6	1986	The uptake of iron from transferrin was limited by the level of endocytosis of transferrin during the initial phase of culture and the number of transferrin receptors at the cell surface during the latter stages of erythroid maturation of these cells.	Iron	14-18	transferrin	Mus musculus	79-90
3007133-2	1986	Porphyrin c, the iron-free derivative of cytochrome c, is a reasonably good model for cytochrome c binding to cytochrome c peroxidase (CcP).	Iron	17-21	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	110-133
25075125-1	2014	Expression of hepcidin, the hepatic hormone controlling iron homeostasis, is regulated by bone morphogenetic protein (BMP) signaling.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	14-22
25075125-6	2014	Iron injection increased hepatic hepcidin mRNA levels in mice deficient in either BMPR2 or ActR2a, but not in mice deficient in both BMP type II receptors.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	33-41
25115987-7	2014	Spin polarized density functional calculations suggest the occurrence of different magnetic moments at the Fe sites in the Ru substituted compounds, and provide a rationale for the experimentally observed multimodel B(hf).	Iron	107-109	spindlin 1	Homo sapiens	0-4
3007133-2	1986	Porphyrin c, the iron-free derivative of cytochrome c, is a reasonably good model for cytochrome c binding to cytochrome c peroxidase (CcP).	Iron	17-21	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	135-138
3700269-0	1986	Role of uteroferrin in placental iron transport in swine: relationship between uteroferrin levels and iron deposition in the conceptus during gestation.	Iron	102-106	acid phosphatase 5, tartrate resistant	Sus scrofa	79-90
24751692-6	2014	The main categories of genes affected by the inhibition of MTF-1 signaling were: nuclear receptors and genes involved in stress signaling, neurogenesis, muscle development and contraction, eye development, and metal homeostasis, including novel observations in iron and heme homeostasis.	Iron	261-265	metal-regulatory transcription factor 1	Danio rerio	59-64
3700269-1	1986	This study was to examine the relationship between uteroferrin and Fe, and Fe and Cu in the fetal pig.	Iron	67-69	acid phosphatase 5, tartrate resistant	Sus scrofa	51-62
3700269-11	1986	Uteroferrin, measured indirectly by acid phosphatase activity and Fe in fetal tissues and fluid underwent closely related temporal changes between d 30 and 112 of gestation.	Iron	66-68	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
25309795-7	2014	Furthermore, iron, rather than carbon monoxide, was involved in the HO-1-mediated survival effect.	Iron	13-17	heme oxygenase 1	Rattus norvegicus	68-72
3700269-15	1986	It was concluded that uteroferrin provides a major source of Fe in endometrial secretion and that it may be stored in placental and endometrial tissues.	Iron	61-63	acid phosphatase 5, tartrate resistant	Sus scrofa	22-33
4088433-5	1985	When methylamine or ammonium chloride was added, (both known inhibitors of transferrin iron release because of their lysosomotropic properties), total iron uptake was diminished.	Iron	87-91	transferrin	Mus musculus	75-86
24980968-6	2014	We hypothesized that the robust immune response to Ent and Lcn2 requires iron chelation rather than the Ent+Lcn2 complex itself and also can be stimulated by Lcn2-evasive siderophores.	Iron	73-77	lipocalin 2	Homo sapiens	59-63
24980968-9	2014	Iron chelation by excess Ent or Ybt significantly increased Lcn2-induced secretion of IL-8, IL-6, and CCL20.	Iron	0-4	lipocalin 2	Homo sapiens	60-64
24752528-8	2014	In strain cia3, defective in the lumenal carbonic anhydrase (CA), the cell quotas of P, S, Ca, Mn, Fe, and Zn were about 5-fold higher at low CO2 than at high CO2.	Iron	99-101	uncharacterized protein	Chlamydomonas reinhardtii	41-59
24752528-8	2014	In strain cia3, defective in the lumenal carbonic anhydrase (CA), the cell quotas of P, S, Ca, Mn, Fe, and Zn were about 5-fold higher at low CO2 than at high CO2.	Iron	99-101	uncharacterized protein	Chlamydomonas reinhardtii	61-63
4088433-5	1985	When methylamine or ammonium chloride was added, (both known inhibitors of transferrin iron release because of their lysosomotropic properties), total iron uptake was diminished.	Iron	151-155	transferrin	Mus musculus	75-86
4088433-8	1985	The data reinforces the likelihood that iron uptake by nervous tissues is transferrin-mediated.	Iron	40-44	transferrin	Mus musculus	74-85
4054239-5	1985	This transferrin saturation effect may be overcome by a simple modification involving the addition of iron to the culture medium.	Iron	102-106	transferrin	Mus musculus	5-16
24729434-4	2014	Our results show that adding in sodium nitrite lead to the transition from HbO2 (Fe(2+) ) to MetHb (Fe(3+) ) in whole blood, and the iron atom converts from the low spin state to the high spin state with a delocalization from porphyrin plane.	Iron	133-137	hemoglobin subunit gamma 2	Homo sapiens	93-98
2998248-1	1985	The mixture of low and high iron spin states is studied by electron spin resonance in methemoglobin and in metmyoglobin between 6K and 100K.	Iron	28-32	hemoglobin subunit gamma 2	Homo sapiens	86-99
24859195-0	2014	Characterization of biofilm and corrosion of cast iron pipes in drinking water distribution system with UV/Cl2 disinfection.	Iron	50-54	endogenous retrovirus group W member 5	Homo sapiens	107-110
24859195-2	2014	Passivation occurred more rapidly in the AR with UV/Cl2 than in the one with Cl2 alone, decreasing iron release for higher corrosivity of water.	Iron	99-103	endogenous retrovirus group W member 5	Homo sapiens	52-55
24859195-2	2014	Passivation occurred more rapidly in the AR with UV/Cl2 than in the one with Cl2 alone, decreasing iron release for higher corrosivity of water.	Iron	99-103	endogenous retrovirus group W member 5	Homo sapiens	77-80
24859195-4	2014	The nitrate-reducing bacteria (NRB) Dechloromonas exhibited the greatest corrosion inhibition by inducing the redox cycling of iron to enhance the precipitation of iron oxides and formation of Fe3O4 in the AR with UV/Cl2, while the rhizobia Bradyrhizobium and Rhizobium, and the NRB Sphingomonas, Brucella producing siderophores had weaker corrosion-inhibition effect by capturing iron in the AR with Cl2.	Iron	127-131	endogenous retrovirus group W member 5	Homo sapiens	217-220
3967035-3	1985	The iron-bound N-3 of the model complexes exhibited two infrared stretching bands, which were assigned to the high- and low-spin peaks.	Iron	4-8	spindlin 1	Homo sapiens	124-128
24859195-4	2014	The nitrate-reducing bacteria (NRB) Dechloromonas exhibited the greatest corrosion inhibition by inducing the redox cycling of iron to enhance the precipitation of iron oxides and formation of Fe3O4 in the AR with UV/Cl2, while the rhizobia Bradyrhizobium and Rhizobium, and the NRB Sphingomonas, Brucella producing siderophores had weaker corrosion-inhibition effect by capturing iron in the AR with Cl2.	Iron	127-131	endogenous retrovirus group W member 5	Homo sapiens	401-404
25106452-5	2014	RESULTS: Here, we isolated stem cell antigen-1 positive cells from postnatal mouse heart by magnetic active cell sorting using an iron-labeled anti-mouse Sca-1 antibody, and cultured them long-term in vitro.	Iron	130-134	lymphocyte antigen 6 complex, locus A	Mus musculus	27-46
25106452-5	2014	RESULTS: Here, we isolated stem cell antigen-1 positive cells from postnatal mouse heart by magnetic active cell sorting using an iron-labeled anti-mouse Sca-1 antibody, and cultured them long-term in vitro.	Iron	130-134	lymphocyte antigen 6 complex, locus A	Mus musculus	154-159
25096529-2	2014	Hepcidin is a beta-defensin-like antimicrobial peptide and acts as a principal iron regulatory hormone.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	0-8
25096529-10	2014	The levels of hepcidin-related iron export protein ferroportin were measured, and the iron content and function of alveolar macrophages were evaluated.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	14-22
25096529-13	2014	The knockdown of hepcidin in airway epithelial cells also led to reduced ferroportin degradation and a low intracellular iron content in alveolar macrophages.	Iron	121-125	hepcidin antimicrobial peptide	Mus musculus	17-25
25096529-16	2014	The severe lung injury in the airway epithelial cell-derived hepcidin knockdown mice is at least partially related to the altered intracellular iron level and function of alveolar macrophages.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	61-69
25100063-0	2014	Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	29-37
25100063-1	2014	The regulatory axis between the iron hormone hepcidin and its receptor, the iron exporter ferroportin (FPN), is central to iron homeostasis.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	45-53
25100063-1	2014	The regulatory axis between the iron hormone hepcidin and its receptor, the iron exporter ferroportin (FPN), is central to iron homeostasis.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	45-53
25100063-2	2014	Mutations preventing hepcidin-mediated degradation of FPN cause systemic iron overload.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	21-29
25100063-7	2014	This work uncovers the critical importance of the hepcidin-ferroportin regulatory axis for life and unveils the sensitivity of the exocrine pancreas to iron overload.	Iron	152-156	hepcidin antimicrobial peptide	Mus musculus	50-58
24958018-5	2014	Compared to healthy subjects, at baseline, patients with PTB had lower serum iron levels, higher copper levels and copper/zinc ratio, and similar zinc levels.	Iron	77-81	polypyrimidine tract binding protein 1	Homo sapiens	57-60
24681594-3	2014	Structures of TbpA/B and HmuUV provided new insight into iron uptake by pathogenic bacteria while the structures of NarK, ASBT, and VcINDY revealed molecular details about the transport of nitrate, bile acids and dicarboxylates, respectively.	Iron	57-61	transthyretin	Homo sapiens	14-18
24973448-0	2014	Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	76-84
24973448-2	2014	Abnormally elevated expression of the hormone hepcidin, the central regulator of systemic iron homeostasis, has been implicated in these abnormalities.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	46-54
24889527-8	2014	Furthermore, we showed that MED16 interacted with FIT and improved the binding of the FIT/Ib bHLH complex to FRO2 and IRT1 promoters under iron-deficient conditions.	Iron	139-143	iron-regulated transporter 1	Arabidopsis thaliana	118-122
25120486-1	2014	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism.	Iron	133-137	aconitase 1	Mus musculus	0-32
25120486-1	2014	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism.	Iron	133-137	aconitase 1	Mus musculus	34-38
25120486-1	2014	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism.	Iron	133-137	iron responsive element binding protein 2	Mus musculus	43-47
25120486-6	2014	Thus, IRP1 emerged as a key regulator of erythropoiesis and iron absorption by controlling hypoxia inducible factor 2alpha (HIF2alpha) mRNA translation, while IRP2 appears to dominate the control of iron uptake and heme biosynthesis in erythroid progenitor cells by regulating the expression of transferrin receptor 1 (TfR1) and 5-aminolevulinic acid synthase 2 (ALAS2) mRNAs, respectively.	Iron	60-64	aconitase 1	Mus musculus	6-10
25120486-8	2014	Thus, Irp1(-/-) mice develop polycythemia and pulmonary hypertension, while Irp2(-/-) mice present with microcytic anemia, iron overload in the intestine and the liver, and neurologic defects.	Iron	123-127	iron responsive element binding protein 2	Mus musculus	76-80
25002507-2	2014	The spin crossover in iron in ferropericlase (Fp), the second most abundant phase in the lower mantle, introduces unfamiliar effects on seismic velocities.	Iron	22-26	spindlin 1	Homo sapiens	4-8
25006035-0	2014	The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster.	Iron	37-41	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	22-27
25006035-2	2014	In this study, we show Drosophila ZIP13 (Slc39a13), a presumed zinc importer, fulfills the iron effluxing role.	Iron	91-95	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	34-39
25006035-3	2014	Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion.	Iron	42-46	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	17-23
25006035-3	2014	Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion.	Iron	57-61	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	17-23
25006035-3	2014	Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion.	Iron	57-61	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	17-23
25006035-3	2014	Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion.	Iron	57-61	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	17-23
25006035-4	2014	dZIP13 expression in E. coli confers upon the host iron-dependent growth and iron resistance.	Iron	51-55	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	0-6
25006035-4	2014	dZIP13 expression in E. coli confers upon the host iron-dependent growth and iron resistance.	Iron	77-81	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	0-6
25006035-5	2014	Importantly, time-coursed transport assays using an iron isotope indicated a potent iron exporting activity of dZIP13.	Iron	52-56	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	111-117
25006035-5	2014	Importantly, time-coursed transport assays using an iron isotope indicated a potent iron exporting activity of dZIP13.	Iron	84-88	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	111-117
25006035-6	2014	The identification of dZIP13 as an iron transporter suggests that the spondylocheiro dysplastic form of Ehlers-Danlos syndrome, in which hZIP13 is defective, is likely due to a failure of iron delivery to the secretory compartments.	Iron	35-39	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	22-28
24807908-4	2014	Unique among the Shc family, transcription of p66Shc is activated through the antioxidant response element (ARE)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in K562 human erythroleukemia and other cell types after treatment with hemin, an iron-containing porphyrin.	Iron	254-258	SHC adaptor protein 1	Homo sapiens	17-20
24970260-0	2014	The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	107-115
24970260-2	2014	These Hepc knockout (KO) mice have age-dependent systemic and retinal iron accumulation leading to retinal degeneration.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	6-10
24970260-7	2014	Immunolabeling with L-ferritin and transferrin receptor antibodies showed a decreased signal for L-ferritin in the inner retina and RPE cells and an increased signal for transferrin receptor in the inner retina, indicating diminished retinal iron levels with DFP treatment.	Iron	242-246	ferritin light polypeptide 1	Mus musculus	20-30
24970260-7	2014	Immunolabeling with L-ferritin and transferrin receptor antibodies showed a decreased signal for L-ferritin in the inner retina and RPE cells and an increased signal for transferrin receptor in the inner retina, indicating diminished retinal iron levels with DFP treatment.	Iron	242-246	transferrin	Mus musculus	35-46
24970260-12	2014	CONCLUSIONS: Long-term treatment with the oral iron chelator DFP diminished retinal and RPE iron levels and oxidative stress, providing significant protection against retinal degeneration caused by chronic systemic iron overload in Hepc KO mice.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	232-236
24849670-0	2014	Spin-polarized currents generated by magnetic Fe atomic chains.	Iron	46-48	spindlin 1	Homo sapiens	0-4
24849670-1	2014	Fe-based devices are widely used in spintronics because of high spin-polarization and magnetism.	Iron	0-2	spindlin 1	Homo sapiens	36-40
24849670-2	2014	In this work, freestanding Fe atomic chains, the thinnest wires, were used to generate spin-polarized currents due to the spin-polarized energy bands.	Iron	27-29	spindlin 1	Homo sapiens	87-91
24849670-2	2014	In this work, freestanding Fe atomic chains, the thinnest wires, were used to generate spin-polarized currents due to the spin-polarized energy bands.	Iron	27-29	spindlin 1	Homo sapiens	122-126
24849670-5	2014	A system constructed by a short Fe chain sandwiched between two graphene electrodes could be used as a spin-polarized current generator, while a C chain could not be used in this way.	Iron	32-34	spindlin 1	Homo sapiens	103-107
24561287-0	2014	Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	0-8
24561287-4	2014	Systemic iron homeostasis is fundamentally governed by the hepcidin-ferroportin regulatory axis, where hepcidin is the key regulator.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	59-67
24561287-4	2014	Systemic iron homeostasis is fundamentally governed by the hepcidin-ferroportin regulatory axis, where hepcidin is the key regulator.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	103-111
24561287-5	2014	Hepcidin deficiency could induce a few disorders, of which iron overload is the most representative phenotype.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	0-8
24561287-8	2014	Our results revealed that significant iron overload was induced in Hamp1(-/-) mice.	Iron	38-42	hepcidin antimicrobial peptide	Mus musculus	67-72
24803276-0	2014	The effect of SMS messaging on the compliance with iron supplementation among pregnant women in Iran: a randomized controlled trial.	Iron	51-55	spermine synthase	Homo sapiens	14-17
24803276-1	2014	We examined the effect of SMS text messages on compliance with iron supplementation among pregnant women.	Iron	63-67	spermine synthase	Homo sapiens	26-29
24803276-8	2014	Using SMS reminders is an efficient way of improving compliance of women with iron supplementation during pregnancy.	Iron	78-82	spermine synthase	Homo sapiens	6-9
24845074-1	2014	Yellow stripe-like1 (YSL1) and YSL3 are involved in iron (Fe) and copper (Cu) translocation.	Iron	52-56	YELLOW STRIPE like 3	Arabidopsis thaliana	31-35
24845074-1	2014	Yellow stripe-like1 (YSL1) and YSL3 are involved in iron (Fe) and copper (Cu) translocation.	Iron	58-60	YELLOW STRIPE like 3	Arabidopsis thaliana	31-35
3871421-7	1985	These results indicate that decreased lymphocyte proliferative responses in iron deficiency may be due to inadequate levels of circulating transferrin-bound iron, rather than to intrinsic defects in the cells themselves or changes in the proportions of different T-cell subsets, and that iron availability does not affect protein synthesis by proliferating lymphocytes.	Iron	76-80	transferrin	Mus musculus	139-150
24785783-0	2014	Mossbauer, EPR, and modeling study of iron trafficking and regulation in Deltaccc1 and CCC1-up Saccharomyces cerevisiae.	Iron	38-42	Ccc1p	Saccharomyces cerevisiae S288C	87-91
24785783-1	2014	Strains lacking and overexpressing the vacuolar iron (Fe) importer CCC1 were characterized using Mossbauer and EPR spectroscopies.	Iron	48-52	Ccc1p	Saccharomyces cerevisiae S288C	67-71
24785783-2	2014	Vacuolar Fe import is impeded in Deltaccc1 cells and enhanced in CCC1-up cells, causing vacuolar Fe in these strains to decline and accumulate, respectively, relative to WT cells.	Iron	9-11	Ccc1p	Saccharomyces cerevisiae S288C	65-69
24785783-2	2014	Vacuolar Fe import is impeded in Deltaccc1 cells and enhanced in CCC1-up cells, causing vacuolar Fe in these strains to decline and accumulate, respectively, relative to WT cells.	Iron	97-99	Ccc1p	Saccharomyces cerevisiae S288C	65-69
24785783-9	2014	The Fe concentration in CCC1-up cells was higher than in WT cells; the extra Fe was present as NHHS Fe(II) and Fe(III) and as Fe(III) oxyhydroxide nanoparticles.	Iron	4-6	Ccc1p	Saccharomyces cerevisiae S288C	24-28
24785783-9	2014	The Fe concentration in CCC1-up cells was higher than in WT cells; the extra Fe was present as NHHS Fe(II) and Fe(III) and as Fe(III) oxyhydroxide nanoparticles.	Iron	77-79	Ccc1p	Saccharomyces cerevisiae S288C	24-28
3871421-7	1985	These results indicate that decreased lymphocyte proliferative responses in iron deficiency may be due to inadequate levels of circulating transferrin-bound iron, rather than to intrinsic defects in the cells themselves or changes in the proportions of different T-cell subsets, and that iron availability does not affect protein synthesis by proliferating lymphocytes.	Iron	157-161	transferrin	Mus musculus	139-150
3007247-1	1985	The iron-carrying serum protein transferrin is required for the proliferation and differentiation of embryonic tissues in culture.	Iron	4-8	transferrin	Mus musculus	32-43
24415655-3	2014	These differences in erythrocyte parameters suggest anemia in many inflammatory states may not be fully explained by hepcidin-mediated iron sequestration.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	117-125
24415655-11	2014	Our results suggest chronic anemia associated with inflammation may benefit from interventions protecting erythrocyte number in addition to anti-hepcidin interventions aimed at enhancing iron availability.	Iron	187-191	hepcidin antimicrobial peptide	Mus musculus	145-153
3007247-6	1985	Our results suggest that the antibody to the transferrin receptor inhibits development by blocking the normal endocytotic route of iron delivery.	Iron	131-135	transferrin	Mus musculus	45-56
3000916-1	1985	The iron storage ferritin light-chain gene exhibits multiple restriction enzyme fragments which have been mapped by analyzing sorted human chromosomes.	Iron	4-8	ferritin light chain	Homo sapiens	17-37
24632386-4	2014	Of the four type CEINs (the mean diameter 47-56 nm) studied here, the as-synthesized raw nanoparticles (Fe@C/Fe) exhibited high cytotoxic effects on the plasma cell membrane (LDH, Calcein AM/PI) and mitochondria (MTT, JC-1) causing some pro-apoptotic evens (Annexin V/PI) in glioma cells.	Iron	104-106	annexin A5	Mus musculus	258-267
4008170-0	1985	Transmembrane transport of iron from extracellular transferrin by lymphoma cells.	Iron	27-31	transferrin	Mus musculus	51-62
24695223-5	2014	Unbiased identification of NCOA4-associated proteins revealed ferritin heavy and light chains, components of an iron-filled cage structure that protects cells from reactive iron species but is degraded via autophagy to release iron through an unknown mechanism.	Iron	112-116	nuclear receptor coactivator 4	Homo sapiens	27-32
24695223-5	2014	Unbiased identification of NCOA4-associated proteins revealed ferritin heavy and light chains, components of an iron-filled cage structure that protects cells from reactive iron species but is degraded via autophagy to release iron through an unknown mechanism.	Iron	173-177	nuclear receptor coactivator 4	Homo sapiens	27-32
24695223-5	2014	Unbiased identification of NCOA4-associated proteins revealed ferritin heavy and light chains, components of an iron-filled cage structure that protects cells from reactive iron species but is degraded via autophagy to release iron through an unknown mechanism.	Iron	173-177	nuclear receptor coactivator 4	Homo sapiens	27-32
24695223-7	2014	This work identifies NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (ferritinophagy), which is critical for iron homeostasis, and provides a resource for further dissection of autophagosomal cargo-receptor connectivity.	Iron	133-137	nuclear receptor coactivator 4	Homo sapiens	21-26
4008170-1	1985	Transferrin is essential for the entry of iron into cells, but whether the entire iron-transferrin complex or only the iron enters is not known.	Iron	42-46	transferrin	Mus musculus	0-11
24705334-2	2014	FRDA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters.	Iron	132-136	frataxin	Mus musculus	0-4
4008170-1	1985	Transferrin is essential for the entry of iron into cells, but whether the entire iron-transferrin complex or only the iron enters is not known.	Iron	82-86	transferrin	Mus musculus	0-11
4008170-1	1985	Transferrin is essential for the entry of iron into cells, but whether the entire iron-transferrin complex or only the iron enters is not known.	Iron	82-86	transferrin	Mus musculus	87-98
4008170-1	1985	Transferrin is essential for the entry of iron into cells, but whether the entire iron-transferrin complex or only the iron enters is not known.	Iron	82-86	transferrin	Mus musculus	0-11
4008170-1	1985	Transferrin is essential for the entry of iron into cells, but whether the entire iron-transferrin complex or only the iron enters is not known.	Iron	82-86	transferrin	Mus musculus	87-98
24691196-0	2014	Spin-dependent electronic conduction along zigzag graphene nanoribbons bearing adsorbed Ni and Fe nanostructures.	Iron	95-97	spindlin 1	Homo sapiens	0-4
3964933-4	1985	The relaxation rates 1/T2 and 1/T1 both showed a linear relationship to hepatic iron levels.	Iron	80-84	solute carrier family 25 member 5	Homo sapiens	23-31
24860503-3	2014	HO-1 releases Fe(2+) from heme, and the ferritin heavy chain (FHC) ferroxidase oxidizes Fe(2+) to catalytically inactive Fe(3+) inside ferritin.	Iron	14-16	ferritin heavy polypeptide 1	Mus musculus	62-65
24860503-3	2014	HO-1 releases Fe(2+) from heme, and the ferritin heavy chain (FHC) ferroxidase oxidizes Fe(2+) to catalytically inactive Fe(3+) inside ferritin.	Iron	88-90	ferritin heavy polypeptide 1	Mus musculus	40-60
6437985-7	1984	The results of this study suggest that transferrin and ceruloplasmin may be synthesized partly in response to the altered iron metabolism observed during hypoferremia.	Iron	122-126	transferrin	Mus musculus	39-50
24721759-0	2014	Hormone influence on the spatial regulation of IRT1 expression in iron-deficient Arabidopsis thaliana roots.	Iron	66-70	iron-regulated transporter 1	Arabidopsis thaliana	47-51
24721759-1	2014	The IRON-REGULATED TRANSPORTER1 (IRT1) is the principal importer of soil iron in Arabidopsis thaliana.	Iron	73-77	iron-regulated transporter 1	Arabidopsis thaliana	4-31
24721759-1	2014	The IRON-REGULATED TRANSPORTER1 (IRT1) is the principal importer of soil iron in Arabidopsis thaliana.	Iron	73-77	iron-regulated transporter 1	Arabidopsis thaliana	33-37
6331321-0	1984	The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase.	Iron	12-16	cytochrome p450 oxidoreductase	Rattus norvegicus	82-114
24721759-4	2014	In its absence, IRT1 is mistargeted for degradation, resulting in reduced plant iron-uptake efficiency.	Iron	80-84	iron-regulated transporter 1	Arabidopsis thaliana	16-20
24721759-6	2014	We tested the influence of two hormones known to positively affect iron uptake on IRT1 spatial regulation.	Iron	67-71	iron-regulated transporter 1	Arabidopsis thaliana	82-86
24532803-6	2014	We observed that the chelator, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), which forms redox-active iron and copper complexes, effectively induced ER stress as shown by activation of the PERK/eIF2alpha pathway.	Iron	118-122	eukaryotic translation initiation factor 2A	Homo sapiens	210-219
18963641-1	1984	The ion-pair extraction equilibria of the iron(II) and iron(III) chelates of 4-(2-pyridylazo)resorcinol (PAR, H(2)L) are described.	Iron	42-46	jumping translocation breakpoint	Homo sapiens	105-108
24860871-1	2014	Growth differentiation factor 15 (GDF-15) is a bone marrow-derived cytokine whose ability to suppress iron regulator hepcidin in vitro and increased concentrations found in patients with ineffective erythropoiesis (IE)suggest that hepcidin deficiency mediated by GDF-15 may be the pathophysiological explanation for nontransfusional iron overload.	Iron	102-106	growth differentiation factor 15	Homo sapiens	0-32
24860871-1	2014	Growth differentiation factor 15 (GDF-15) is a bone marrow-derived cytokine whose ability to suppress iron regulator hepcidin in vitro and increased concentrations found in patients with ineffective erythropoiesis (IE)suggest that hepcidin deficiency mediated by GDF-15 may be the pathophysiological explanation for nontransfusional iron overload.	Iron	102-106	growth differentiation factor 15	Homo sapiens	34-40
24860871-1	2014	Growth differentiation factor 15 (GDF-15) is a bone marrow-derived cytokine whose ability to suppress iron regulator hepcidin in vitro and increased concentrations found in patients with ineffective erythropoiesis (IE)suggest that hepcidin deficiency mediated by GDF-15 may be the pathophysiological explanation for nontransfusional iron overload.	Iron	333-337	growth differentiation factor 15	Homo sapiens	0-32
24860871-1	2014	Growth differentiation factor 15 (GDF-15) is a bone marrow-derived cytokine whose ability to suppress iron regulator hepcidin in vitro and increased concentrations found in patients with ineffective erythropoiesis (IE)suggest that hepcidin deficiency mediated by GDF-15 may be the pathophysiological explanation for nontransfusional iron overload.	Iron	333-337	growth differentiation factor 15	Homo sapiens	34-40
18963641-1	1984	The ion-pair extraction equilibria of the iron(II) and iron(III) chelates of 4-(2-pyridylazo)resorcinol (PAR, H(2)L) are described.	Iron	55-59	jumping translocation breakpoint	Homo sapiens	105-108
18963641-6	1984	The relationship between the forms and extraction properties of the iron(II) and iron(III) PAR chelates are discussed in connection with those of the nickel(II) and cobalt(III) complexes.	Iron	68-72	jumping translocation breakpoint	Homo sapiens	91-94
18963641-6	1984	The relationship between the forms and extraction properties of the iron(II) and iron(III) PAR chelates are discussed in connection with those of the nickel(II) and cobalt(III) complexes.	Iron	81-85	jumping translocation breakpoint	Homo sapiens	91-94
24492796-12	2014	CONCLUSIONS: Scalds to infants and toddlers who pull hot beverages over themselves or sustain burns from touching irons, hair straighteners or oven hobs are a high priority for targeted prevention.	Iron	114-119	alcohol dehydrogenase iron containing 1	Homo sapiens	53-56
6425295-8	1984	The affinity of the enzyme for zinc lowers the actual determination of ferrochelatase activity with iron as substrate.	Iron	100-104	ferrochelatase	Homo sapiens	71-85
6323451-0	1984	Iron-sulfur cluster 3 of beef heart succinate-ubiquinone oxidoreductase is a 3-iron cluster.	Iron	0-4	thioredoxin reductase 1	Homo sapiens	57-71
24361124-0	2014	Gluconeogenic signals regulate iron homeostasis via hepcidin in mice.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	52-60
24111973-4	2014	Exogenous ABA promoted the secretion of phenolics to release apoplastic Fe and up-regulated the expression of AtNRAMP3 to enhance reutilization of Fe stored in the vacuoles, leading to a higher level of soluble Fe and lower ferric-chelate reductase (FCR) activity in roots.	Iron	147-149	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	110-118
24111973-4	2014	Exogenous ABA promoted the secretion of phenolics to release apoplastic Fe and up-regulated the expression of AtNRAMP3 to enhance reutilization of Fe stored in the vacuoles, leading to a higher level of soluble Fe and lower ferric-chelate reductase (FCR) activity in roots.	Iron	147-149	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	110-118
6323451-0	1984	Iron-sulfur cluster 3 of beef heart succinate-ubiquinone oxidoreductase is a 3-iron cluster.	Iron	79-83	thioredoxin reductase 1	Homo sapiens	57-71
6323451-1	1984	From a study of the magnetic field dependence of the linear electric field effect (LEFE) in EPR spectroscopy, we demonstrate that iron-sulfur cluster 3 in air-oxidized, beef heart succinate-ubiquinone oxidoreductase (Complex II) is a 3-iron cluster.	Iron	130-134	thioredoxin reductase 1	Homo sapiens	201-215
6323451-1	1984	From a study of the magnetic field dependence of the linear electric field effect (LEFE) in EPR spectroscopy, we demonstrate that iron-sulfur cluster 3 in air-oxidized, beef heart succinate-ubiquinone oxidoreductase (Complex II) is a 3-iron cluster.	Iron	236-240	thioredoxin reductase 1	Homo sapiens	201-215
6421970-9	1984	Because the amidolytic activity of human thrombin as well as factor Xa, kallikrein, and bovine trypsin was also reversibly suppressed by ferrous sulfate as well as ferric citrate, we consider it likely that the coagulopathy occurring in iron poisoning is the consequence of a general, physiologically important phenomenon: the susceptibility of serine proteases to nontransferrin-bound Fe3+.	Iron	237-241	coagulation factor X	Homo sapiens	61-70
24711810-5	2014	The resulting ferrous iron is subsequently transported across the plasma membrane of root epidermal cells by the ferrous iron transporter, IRT1.	Iron	22-26	iron-regulated transporter 1	Arabidopsis thaliana	139-143
24448401-7	2014	Elevation of SOD1 and increasing trend for iron-storage proteins (FTL, FTH1) may be indicative of an oxidative imbalance that is accompanied by an aberrant iron metabolism.	Iron	43-47	ferritin light chain	Homo sapiens	66-69
6323433-3	1984	In this present study, we have investigated the hypothesis that iron-catalyzed formation of hydroxyl radical (.OH) from superoxide anion radical (O-.2) and H2O2 requires the availability of at least one iron coordination site that is open or occupied by a readily dissociable ligand such as water.	Iron	64-68	immunoglobulin kappa variable 1D-39	Homo sapiens	146-150
25206866-4	2014	Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins.	Iron	20-24	RoBo-1	Rattus norvegicus	62-90
25206866-7	2014	These results indicate that baicalin down-regulated iron concentration, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.	Iron	52-56	RoBo-1	Rattus norvegicus	99-127
6323433-3	1984	In this present study, we have investigated the hypothesis that iron-catalyzed formation of hydroxyl radical (.OH) from superoxide anion radical (O-.2) and H2O2 requires the availability of at least one iron coordination site that is open or occupied by a readily dissociable ligand such as water.	Iron	203-207	immunoglobulin kappa variable 1D-39	Homo sapiens	146-150
6323433-4	1984	This hypothesis was tested by measuring the catalytic activity of 12 different iron chelates using hypoxanthine and xanthine oxidase to generate O-.2.	Iron	79-83	immunoglobulin kappa variable 1D-39	Homo sapiens	145-149
6534827-4	1984	Transferrin was bound by the transforming cells, and subsequently released without degradation following the delivery of iron.	Iron	121-125	transferrin	Mus musculus	0-11
24625978-0	2014	Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress.	Iron	114-118	hyaluronan and proteoglycan link protein 1	Mus musculus	10-22
24361204-3	2014	Among these, ATP13A2 and PLA2G6 are inconsistently associated with brain iron deposition.	Iron	73-77	ATPase cation transporting 13A2	Homo sapiens	13-20
24361204-4	2014	Using homozygosity mapping and direct sequencing in a multiplex consanguineous Saudi Arabian family with a pallido-pyramidal syndrome, iron deposition and cerebellar atrophy, we identified a homozygous p.G53R mutation in C19orf12.	Iron	135-139	chromosome 19 open reading frame 12	Homo sapiens	221-229
24325979-2	2014	Iron status influences C-terminal FGF23 (incorporating fragments plus intact FGF23) in ADHR and healthy subjects, and intact FGF23 in ADHR.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	34-39
24325979-2	2014	Iron status influences C-terminal FGF23 (incorporating fragments plus intact FGF23) in ADHR and healthy subjects, and intact FGF23 in ADHR.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	77-82
6534827-7	1984	It is postulated that transferrin may fulfil functions additional to that of supplying iron.	Iron	87-91	transferrin	Mus musculus	22-33
24325979-2	2014	Iron status influences C-terminal FGF23 (incorporating fragments plus intact FGF23) in ADHR and healthy subjects, and intact FGF23 in ADHR.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	77-82
24325979-3	2014	We hypothesized that in XLH serum iron would inversely correlate to C-terminal FGF23, but not to intact FGF23, mirroring the relationships in normal controls.	Iron	34-38	fibroblast growth factor 23	Homo sapiens	79-84
6693129-1	1984	A new G6PD variant, designated Gd (+) Laguna, was found in a 9-year-old Brazilian boy of Portuguese ancestry suffering from an iron-refractory anemia.	Iron	127-131	glucose-6-phosphate dehydrogenase	Homo sapiens	6-10
24325979-7	2014	In XLH, iron correlated negatively to log-C-terminal FGF23 (r=-0.523, p&lt;0.01), with a steeper slope than in controls (p&lt;0.001).	Iron	8-12	fibroblast growth factor 23	Homo sapiens	53-58
24325979-9	2014	The log-ratio of intact FGF23 to C-terminal FGF23 was higher in XLH (0.00+-0.44) than controls (-0.28+-0.21, p&lt;0.01), and correlated positively to serum iron (controls r=0.276, p&lt;0.001; XLH r=0.428, p&lt;0.05), with a steeper slope in XLH (p&lt;0.01).	Iron	156-160	fibroblast growth factor 23	Homo sapiens	24-29
6693981-3	1984	Reduced glutathione significantly increased the absorption from nonheme and heme iron present in black beans, corn and hemoglobin.	Iron	81-85	non-symbiotic hemoglobin	Zea mays	119-129
24342540-1	2014	Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage.	Iron	32-36	hemoglobin subunit gamma 2	Homo sapiens	116-129
24342540-1	2014	Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage.	Iron	32-36	hemoglobin subunit gamma 2	Homo sapiens	131-136
6084237-1	1984	In DNA strand scission of Mn-, Co-, and Fe-complexes of bleomycin-A2 (BLM), the Mn-BLM and Fe-BLM complex systems showed prominent DNA cleavage activity in combination with reductant, hydrogen peroxide, and ultraviolet light.	Iron	40-42	BLM RecQ like helicase	Homo sapiens	56-68
6084237-1	1984	In DNA strand scission of Mn-, Co-, and Fe-complexes of bleomycin-A2 (BLM), the Mn-BLM and Fe-BLM complex systems showed prominent DNA cleavage activity in combination with reductant, hydrogen peroxide, and ultraviolet light.	Iron	40-42	BLM RecQ like helicase	Homo sapiens	70-73
24421385-0	2014	Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.	Iron	107-111	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	0-6
6084237-1	1984	In DNA strand scission of Mn-, Co-, and Fe-complexes of bleomycin-A2 (BLM), the Mn-BLM and Fe-BLM complex systems showed prominent DNA cleavage activity in combination with reductant, hydrogen peroxide, and ultraviolet light.	Iron	40-42	BLM RecQ like helicase	Homo sapiens	83-86
24421385-0	2014	Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.	Iron	107-111	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	42-48
24421385-5	2014	Electron microscopy images of Abcb10(-/-) hematopoietic cells showed a marked increase of iron deposits at the mitochondria.	Iron	90-94	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	30-36
6084237-1	1984	In DNA strand scission of Mn-, Co-, and Fe-complexes of bleomycin-A2 (BLM), the Mn-BLM and Fe-BLM complex systems showed prominent DNA cleavage activity in combination with reductant, hydrogen peroxide, and ultraviolet light.	Iron	40-42	BLM RecQ like helicase	Homo sapiens	83-86
6084237-1	1984	In DNA strand scission of Mn-, Co-, and Fe-complexes of bleomycin-A2 (BLM), the Mn-BLM and Fe-BLM complex systems showed prominent DNA cleavage activity in combination with reductant, hydrogen peroxide, and ultraviolet light.	Iron	91-93	BLM RecQ like helicase	Homo sapiens	56-68
6084237-1	1984	In DNA strand scission of Mn-, Co-, and Fe-complexes of bleomycin-A2 (BLM), the Mn-BLM and Fe-BLM complex systems showed prominent DNA cleavage activity in combination with reductant, hydrogen peroxide, and ultraviolet light.	Iron	91-93	BLM RecQ like helicase	Homo sapiens	70-73
24456400-8	2014	In particular, the transcription levels of FIT, IRT1 and FRO2 were reduced in the yid1 and med25 mutants under iron-deficient conditions.	Iron	111-115	iron-regulated transporter 1	Arabidopsis thaliana	48-52
6616469-2	1983	The 111In-MoAb proved to be stable in vitro and in vivo under normal conditions, although instability could be induced in vitro with large quantities of iron-free transferrin.	Iron	153-157	transferrin	Mus musculus	163-174
24577088-2	2014	MicroRNA-210 (miR-210) is regulated by hypoxia-inducible transcription factor-1alpha (HIF-1alpha) under hypoxic conditions and controls mitochondrial energy metabolism by repressing the iron-sulfur cluster assembly protein (ISCU1/2).	Iron	186-190	iron-sulfur cluster assembly enzyme	Mus musculus	224-231
24577088-3	2014	ISCU1/2 facilitates the assembly of iron-sulfur clusters (ISCs), the prosthetic groups that are critical for mitochondrial oxidation-reduction reactions.	Iron	36-40	iron-sulfur cluster assembly enzyme	Mus musculus	0-7
24422557-8	2014	We further demonstrate that yeast Dph3 (also known as KTI11), a CSL-type zinc finger protein, can bind iron and in the reduced state can serve as an electron donor to reduce the Fe-S cluster in Dph1-Dph2.	Iron	103-107	diphthamide biosynthesis 1	Homo sapiens	194-198
24422557-8	2014	We further demonstrate that yeast Dph3 (also known as KTI11), a CSL-type zinc finger protein, can bind iron and in the reduced state can serve as an electron donor to reduce the Fe-S cluster in Dph1-Dph2.	Iron	178-182	diphthamide biosynthesis 1	Homo sapiens	194-198
6684677-7	1983	Maternal values for hemoglobin, transferrin saturation and red cell folates decreased with iron deficiency and/or 20% EDC; hematocrit, serum iron and serum folates decreased only with iron deficiency.	Iron	91-95	transferrin	Mus musculus	32-43
24422557-11	2014	The finding that Dph3 is an electron donor for the Fe-S clusters in Dph1-Dph2 is thus interesting and opens up new avenues of research on electron transfer to Fe-S proteins in eukaryotic cells.	Iron	51-55	diphthamide biosynthesis 1	Homo sapiens	68-72
24422557-11	2014	The finding that Dph3 is an electron donor for the Fe-S clusters in Dph1-Dph2 is thus interesting and opens up new avenues of research on electron transfer to Fe-S proteins in eukaryotic cells.	Iron	159-163	diphthamide biosynthesis 1	Homo sapiens	68-72
6656532-0	1983	Reduced plasma lecithin cholesterol acyl transferase activity in rats fed iron-deficient diets.	Iron	74-78	lecithin cholesterol acyltransferase	Rattus norvegicus	15-52
24532336-2	2014	The most common treatment options for CRA include iron therapy, erythropoietic-stimulating agents (ESAs), and red cell transfusion.	Iron	50-54	myotubularin related protein 11	Homo sapiens	38-41
24532336-4	2014	Similarly, many clinicians are not familiar or comfortable using intravenous iron products to treat functional iron deficiency associated with CRA.	Iron	77-81	myotubularin related protein 11	Homo sapiens	143-146
24401274-6	2014	Transfection of a CXCR4-expressing human cell line with an iron-deficient FHC mutant confirmed that increased FHC expression deregulated CXCR4 signaling and that this function of FHC was independent of iron binding.	Iron	59-63	C-X-C motif chemokine receptor 4	Homo sapiens	18-23
24401274-6	2014	Transfection of a CXCR4-expressing human cell line with an iron-deficient FHC mutant confirmed that increased FHC expression deregulated CXCR4 signaling and that this function of FHC was independent of iron binding.	Iron	59-63	C-X-C motif chemokine receptor 4	Homo sapiens	137-142
6656532-3	1983	When rats were fed iron-deficient diets, their plasma lecithin cholesterol acyl transferase (LCAT) activity was significantly reduced as compared to controls.	Iron	19-23	lecithin cholesterol acyltransferase	Rattus norvegicus	54-91
6656532-3	1983	When rats were fed iron-deficient diets, their plasma lecithin cholesterol acyl transferase (LCAT) activity was significantly reduced as compared to controls.	Iron	19-23	lecithin cholesterol acyltransferase	Rattus norvegicus	93-97
6656532-10	1983	Thus, changes in LCAT activity and CE/CH ratio in plasma showed the effect of iron-deficient diet consumption even before the blood Hb and Hct levels were reduced.	Iron	78-82	lecithin cholesterol acyltransferase	Rattus norvegicus	17-21
24267341-4	2014	On the other hand, saturation occurred at As/Fe=1 on Cab-O-sil M7D-based adsorbents for all three Fe:aeaptes ratios.	Iron	45-47	neural proliferation, differentiation and control 1	Homo sapiens	53-56
6626200-0	1983	Variable amounts of translatable ferritin mRNA in bean leaves with various iron contents.	Iron	75-79	Fer2	Triticum aestivum	33-41
24021424-8	2014	Wild-type and Nrf2(-/-) mice fed iron-rich diet accumulated similar amounts of iron in the liver and were equally able to increase the expression of hepatic hepcidin and ferritin.	Iron	33-37	hepcidin antimicrobial peptide	Mus musculus	157-165
6626200-4	1983	This implies that the iron-dependent regulation of phytoferritin synthesis, in contrast with the regulation of animal ferritin synthesis, occurs at the level of transcription.	Iron	22-26	Fer2	Triticum aestivum	56-64
6312890-1	1983	Periodate treatments of apo human serum transferrin (HST), and apo chicken ovotransferrin (COT) were previously reported to cause a rapid loss of Fe+3 binding capacity, with a loss of 3 to 5 tyrosine residues [P. AZARI AND J. L. PHILLIPS (1970) Arch.	Iron	146-148	sulfotransferase family 2A member 1	Homo sapiens	53-56
23893294-6	2014	We found that CBD rescued iron-induced effects, bringing hippocampal DNM1L, caspase 3, and synaptophysin levels back to values comparable to the control group.	Iron	26-30	dynamin 1-like	Rattus norvegicus	69-74
23893294-6	2014	We found that CBD rescued iron-induced effects, bringing hippocampal DNM1L, caspase 3, and synaptophysin levels back to values comparable to the control group.	Iron	26-30	synaptophysin	Rattus norvegicus	91-104
6312890-11	1983	After 150 min of 5 mM periodate treatment HST lost approximately 3 (apo 3.1, iron 2.8) of 9, HLT approximately 3 (apo 2.6, iron 2.9) of 6, and COT approximately 7 (apo 7.2, iron 7.2) of 11 methionines per mole of protein.	Iron	77-81	sulfotransferase family 2A member 1	Homo sapiens	42-45
6884442-4	1983	Two methods are proposed to saturate the growth promoting effects of iron-containing transferrin.	Iron	69-73	transferrin	Mus musculus	85-96
24044515-0	2014	Calorie restriction down-regulates expression of the iron regulatory hormone hepcidin in normal and D-galactose-induced aging mouse brain.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	77-85
24044515-10	2014	The results suggest that the anti-aging effects of CR might partially lie in its capacity to reduce or avoid age-related iron accumulation in the brain through down-regulating expression of brain hepcidin--the key negative regulator for intracellular iron efflux--and that facilitating the balance of brain iron metabolism may be a promising anti-aging measure.	Iron	121-125	hepcidin antimicrobial peptide	Mus musculus	196-204
24044515-10	2014	The results suggest that the anti-aging effects of CR might partially lie in its capacity to reduce or avoid age-related iron accumulation in the brain through down-regulating expression of brain hepcidin--the key negative regulator for intracellular iron efflux--and that facilitating the balance of brain iron metabolism may be a promising anti-aging measure.	Iron	251-255	hepcidin antimicrobial peptide	Mus musculus	196-204
24044515-10	2014	The results suggest that the anti-aging effects of CR might partially lie in its capacity to reduce or avoid age-related iron accumulation in the brain through down-regulating expression of brain hepcidin--the key negative regulator for intracellular iron efflux--and that facilitating the balance of brain iron metabolism may be a promising anti-aging measure.	Iron	251-255	hepcidin antimicrobial peptide	Mus musculus	196-204
6137751-0	1983	Reduction of hepatic stearoyl-CoA desaturase activity in rats fed iron-deficient diets.	Iron	66-70	stearoyl-CoA desaturase	Rattus norvegicus	21-44
24803973-3	2014	From simulations, this spin transition behavior was found to be responsible for the strong binding behavior experimentally observed in the iron complex.	Iron	139-143	spindlin 1	Homo sapiens	23-27
24454764-4	2014	Despite liver iron overload, expression of bone morphogenetic protein 6 (Bmp6), a potent-stimulator of Hamp1 expression that is expressed under iron-loaded conditions, was decreased.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	103-108
24454764-6	2014	Our results show that erythropoietin and Tf-bound iron do not underlie the down-regulation of Bmp6 in our mice models.	Iron	50-54	transferrin	Mus musculus	41-43
24454764-9	2014	Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression, and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression.	Iron	66-70	transferrin	Mus musculus	57-59
6137751-1	1983	The effect of feeding iron-deficient diets to rats on the hepatic stearoyl-CoA desaturase activity was examined since iron is present in the delta 9 desaturation system.	Iron	22-26	stearoyl-CoA desaturase	Rattus norvegicus	66-89
24454764-9	2014	Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression, and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression.	Iron	66-70	hepcidin antimicrobial peptide	Mus musculus	81-86
24454764-9	2014	Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression, and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression.	Iron	190-194	transferrin	Mus musculus	181-183
6137751-1	1983	The effect of feeding iron-deficient diets to rats on the hepatic stearoyl-CoA desaturase activity was examined since iron is present in the delta 9 desaturation system.	Iron	118-122	stearoyl-CoA desaturase	Rattus norvegicus	66-89
24454764-9	2014	Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates Hamp1 expression via Smad1/5/8 phosphorylation without affecting Bmp6 expression, and the effect of Tf-bound iron on Hamp1 regulation appeared before a significant change in Bmp6 expression.	Iron	190-194	hepcidin antimicrobial peptide	Mus musculus	198-203
6137751-4	1983	Stearoyl-CoA desaturase activity in the liver microsomes of rats in the CO + Fe group (2.55 +/- 0.17 nmol oleate produced/min/mg protein) was about half of that in the HCNO + Fe (4.76 +/- 0.15) and FF + Fe (5.38 +/- 0.18) diet groups.	Iron	77-79	stearoyl-CoA desaturase	Rattus norvegicus	0-23
6137751-4	1983	Stearoyl-CoA desaturase activity in the liver microsomes of rats in the CO + Fe group (2.55 +/- 0.17 nmol oleate produced/min/mg protein) was about half of that in the HCNO + Fe (4.76 +/- 0.15) and FF + Fe (5.38 +/- 0.18) diet groups.	Iron	175-177	stearoyl-CoA desaturase	Rattus norvegicus	0-23
6308639-3	1983	Our studies show that the environment of one iron site (Fea) of the [4Fe-4S] cluster is drastically altered in the presence of citrate.	Iron	29-33	FEA	Homo sapiens	56-59
24339041-1	2014	AlkB repair enzymes are important nonheme iron enzymes that catalyse the demethylation of alkylated DNA bases in humans, which is a vital reaction in the body that heals externally damaged DNA bases.	Iron	42-46	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-4
24284962-0	2014	Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	39-47
24284962-2	2014	The effect of the administered iron on the iron regulatory system and hepcidin in the liver has not been well studied.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	70-78
24284962-7	2014	Systematic analysis demonstrated that Tfr2 is required for effective upregulation of Bmp6 in response to hepatocyte iron, but not nonparenchymal iron.	Iron	116-120	transferrin receptor 2	Mus musculus	38-42
24284962-9	2014	Our results demonstrate that Hfe and Tfr2 play separate roles in the regulatory responses to iron compartmentalized in different cell types and further elucidates the regulatory mechanisms controlling iron homeostasis.	Iron	93-97	homeostatic iron regulator	Mus musculus	29-32
6308639-4	1983	Fea is the iron acquired during activation of aconitase.	Iron	11-15	FEA	Homo sapiens	0-3
24284962-9	2014	Our results demonstrate that Hfe and Tfr2 play separate roles in the regulatory responses to iron compartmentalized in different cell types and further elucidates the regulatory mechanisms controlling iron homeostasis.	Iron	93-97	transferrin receptor 2	Mus musculus	37-41
6296101-12	1983	These results suggest that an iron-catalyzed Haber-Weiss reaction might be involved in the mechanism by which purified cytochrome P-450 reductase mediates the oxidation of typical hydroxyl radical scavengers.	Iron	30-34	cytochrome p450 oxidoreductase	Rattus norvegicus	119-145
24284962-9	2014	Our results demonstrate that Hfe and Tfr2 play separate roles in the regulatory responses to iron compartmentalized in different cell types and further elucidates the regulatory mechanisms controlling iron homeostasis.	Iron	201-205	homeostatic iron regulator	Mus musculus	29-32
24284962-9	2014	Our results demonstrate that Hfe and Tfr2 play separate roles in the regulatory responses to iron compartmentalized in different cell types and further elucidates the regulatory mechanisms controlling iron homeostasis.	Iron	201-205	transferrin receptor 2	Mus musculus	37-41
6672810-9	1983	Experiments with 59Fe-uteroferrin have shown that allantoic fluid promotes iron loss from uteroferrin and that the metal appears in transferrin.	Iron	75-79	acid phosphatase 5, tartrate resistant	Sus scrofa	90-101
24269900-0	2014	Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.	Iron	27-31	N-myc downstream regulated 1	Homo sapiens	65-70
24269900-3	2014	NDRG1 is regulated by multiple effectors in normal and neoplastic cells, including N-myc, histone acetylation, hypoxia, cellular iron levels and intracellular calcium.	Iron	129-133	N-myc downstream regulated 1	Homo sapiens	0-5
24269900-4	2014	Further, studies have found that NDRG1 is up-regulated in neoplastic cells after treatment with novel iron chelators, which are a promising therapy for effective cancer management.	Iron	102-106	N-myc downstream regulated 1	Homo sapiens	33-38
6277891-2	1982	A relaxation occurring in approximately 100 microseconds involves perturbation of a spin-equilibrium between two folded conformers of the protein with methionine-80 coordinated or dissociated from the heme iron.	Iron	206-210	spindlin 1	Homo sapiens	84-88
24172132-1	2014	The Saccharomyces cerevisiae Aft1 and Kluyveromyces lactis KlAft are orthologous yeast transcription activators that regulate the expression of the same group of iron-uptake genes but bind to the different DNA sites: TGCACCC for Aft1 and PuCACCC for KlAft.	Iron	162-166	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	29-33
24172132-1	2014	The Saccharomyces cerevisiae Aft1 and Kluyveromyces lactis KlAft are orthologous yeast transcription activators that regulate the expression of the same group of iron-uptake genes but bind to the different DNA sites: TGCACCC for Aft1 and PuCACCC for KlAft.	Iron	162-166	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	229-233
24172132-4	2014	We show with deletion mutant analyses that this sequence is essential for the binding of Aft1 to its DNA site and for the iron uptake and growth of S. cerevisiae under iron-limited conditions.	Iron	122-126	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	89-93
24172132-4	2014	We show with deletion mutant analyses that this sequence is essential for the binding of Aft1 to its DNA site and for the iron uptake and growth of S. cerevisiae under iron-limited conditions.	Iron	168-172	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	89-93
24172132-6	2014	We show that the Aft1 region is necessary and sufficient for KlAft to bind efficiently to the Aft1 DNA site in S. cerevisiae and to complement the iron-dependent phenotype of the aft1Deltaaft2Delta mutant.	Iron	147-151	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	17-21
7059591-0	1982	Biphasic uptake of iron-transferrin complex by L1210 murine leukemia cells and rat reticulocytes.	Iron	19-23	transferrin	Mus musculus	24-35
24171419-3	2014	For the UV light photo-Fenton degradation of oolong tea effluent being 70 mg-(polyphenol) L(-1), the optimum dosages of Fenton reagents were found to be 20 mgL(-1) of total Fe and 500 mgL(-1) of H2O2.	Iron	23-25	LLGL scribble cell polarity complex component 1	Homo sapiens	156-162
24171419-3	2014	For the UV light photo-Fenton degradation of oolong tea effluent being 70 mg-(polyphenol) L(-1), the optimum dosages of Fenton reagents were found to be 20 mgL(-1) of total Fe and 500 mgL(-1) of H2O2.	Iron	23-25	LLGL scribble cell polarity complex component 1	Homo sapiens	184-190
25762501-7	2014	We also show that ER stress combined with inflammation synergistically upregulated the expression of the iron carrier protein NGAL and the stress-inducible heme degrading enzyme heme oxygenase-1 (HO-1) leading to iron liberation.	Iron	105-109	lipocalin 2	Homo sapiens	126-130
24174620-7	2014	Enhanced iron uptake by knockdown cells was associated with increased expression of a ferrireductase (duodenal cytochrome b) and activity of a cell-surface ferrireductase.	Iron	9-13	cytochrome b, mitochondrial	Rattus norvegicus	111-123
7059591-1	1982	The kinetics of the cellular uptake of iron-transferrin complex was studied in L1210 murine leukemia cells and rat reticulocytes using 125I-transferrin.	Iron	39-43	transferrin	Mus musculus	44-55
7059591-2	1982	Saturation of transferrin with iron was necessary for optimal uptake.	Iron	31-35	transferrin	Mus musculus	14-25
6941820-3	1981	The amount of iron in a cell grown in the presence of iron citrate is approximately 1.2 X 10(-14) g, whereas in a cell grown in the presence of transferrin the amount is approximately 0.28 X 10(-14) g. These quantities do not depend on the iron concentration in the nutrition medium in a range from 0.3 to 2.0 microgram Fe/ml and are the same for growth times between 8 hr and 7 days.	Iron	14-18	transferrin	Mus musculus	144-155
24993575-13	2014	Whereas iron stores, GA and mode of delivery were associated with Hep(CB), the association with inflammation and intra-uterine growth retardation was less clear.	Iron	8-12	DNL-type zinc finger	Homo sapiens	66-73
6941820-8	1981	Cells grown with transferrin incorporate additional amounts of iron, which are approximately equal to the amounts used for hemoglobin synthesis maintaining a constant ferritin iron level.	Iron	63-67	transferrin	Mus musculus	17-28
24015802-0	2014	Involvement of the ABCG37 transporter in secretion of scopoletin and derivatives by Arabidopsis roots in response to iron deficiency.	Iron	117-121	pleiotropic drug resistance 9	Arabidopsis thaliana	19-25
6941820-8	1981	Cells grown with transferrin incorporate additional amounts of iron, which are approximately equal to the amounts used for hemoglobin synthesis maintaining a constant ferritin iron level.	Iron	176-180	transferrin	Mus musculus	17-28
7252240-4	1981	The activity of heme synthease (ferrochelatase), which catalyzes the chelation of ferrous iron to protoporphyrin, is deficient in tissues of patients with protoporphyria.	Iron	90-94	ferrochelatase	Homo sapiens	32-46
24298997-0	2014	SKB1/PRMT5-mediated histone H4R3 dimethylation of Ib subgroup bHLH genes negatively regulates iron homeostasis in Arabidopsis thaliana.	Iron	94-98	SHK1 binding protein 1	Arabidopsis thaliana	0-4
24298997-0	2014	SKB1/PRMT5-mediated histone H4R3 dimethylation of Ib subgroup bHLH genes negatively regulates iron homeostasis in Arabidopsis thaliana.	Iron	94-98	SHK1 binding protein 1	Arabidopsis thaliana	5-10
24298997-2	2014	Here, we report that Shk1 binding protein 1 (SKB1/AtPRMT5), which catalyzes the symmetric dimethylation of histone H4R3 (H4R3sme2), is involved in iron homeostasis in Arabidopsis.	Iron	147-151	SHK1 binding protein 1	Arabidopsis thaliana	21-43
24298997-2	2014	Here, we report that Shk1 binding protein 1 (SKB1/AtPRMT5), which catalyzes the symmetric dimethylation of histone H4R3 (H4R3sme2), is involved in iron homeostasis in Arabidopsis.	Iron	147-151	SHK1 binding protein 1	Arabidopsis thaliana	45-49
7020431-5	1981	The deciduous teeth of Mesolithic Europeans are comparable in size to certain dimensions of the Inamgaon teeth, and a small sample of deciduous teeth from the Iron Age site of Pomparippu (Sri Lanka) exhibits larger anterior teeth and smaller molar teeth than does the sample from Inamgaon.	Iron	159-163	sorcin	Homo sapiens	188-191
24298997-2	2014	Here, we report that Shk1 binding protein 1 (SKB1/AtPRMT5), which catalyzes the symmetric dimethylation of histone H4R3 (H4R3sme2), is involved in iron homeostasis in Arabidopsis.	Iron	147-151	SHK1 binding protein 1	Arabidopsis thaliana	50-57
24298997-3	2014	The SKB1 lesion mutant exhibited higher iron accumulation in shoots and greater tolerance to iron deficiency than the wild type.	Iron	40-44	SHK1 binding protein 1	Arabidopsis thaliana	4-8
24298997-3	2014	The SKB1 lesion mutant exhibited higher iron accumulation in shoots and greater tolerance to iron deficiency than the wild type.	Iron	93-97	SHK1 binding protein 1	Arabidopsis thaliana	4-8
24298997-4	2014	The expression of SKB1 was not affected by iron, but the level of H4R3sme2 mediated by SKB1 was related to iron status in plants.	Iron	107-111	SHK1 binding protein 1	Arabidopsis thaliana	87-91
24298997-6	2014	The quantity of SKB1 that associated with chromatin of the Ib subgroup bHLH genes and the level of H4R3sme2 corresponded to the iron status of plants (higher with increased iron supply and lower when iron was removed).	Iron	128-132	SHK1 binding protein 1	Arabidopsis thaliana	16-20
24298997-6	2014	The quantity of SKB1 that associated with chromatin of the Ib subgroup bHLH genes and the level of H4R3sme2 corresponded to the iron status of plants (higher with increased iron supply and lower when iron was removed).	Iron	173-177	SHK1 binding protein 1	Arabidopsis thaliana	16-20
24298997-6	2014	The quantity of SKB1 that associated with chromatin of the Ib subgroup bHLH genes and the level of H4R3sme2 corresponded to the iron status of plants (higher with increased iron supply and lower when iron was removed).	Iron	173-177	SHK1 binding protein 1	Arabidopsis thaliana	16-20
6263690-0	1981	Involvement of the iron-sulfur protein of the mitochondrial cytochrome b-c1 complex in the oxidant-induced reduction of cytochrome b.	Iron	19-23	mitochondrially encoded cytochrome b	Homo sapiens	60-72
24989467-11	2014	On the other hand, Fe alone reduced Mtap2, Th and Olig2 expression levels, and increased Emx2.	Iron	19-21	empty spiracles homeobox 2	Homo sapiens	89-93
24989467-12	2014	Combined treatments of Fe with Mn or DA also tended to increase Emx2 expression level.	Iron	23-25	empty spiracles homeobox 2	Homo sapiens	64-68
6263690-0	1981	Involvement of the iron-sulfur protein of the mitochondrial cytochrome b-c1 complex in the oxidant-induced reduction of cytochrome b.	Iron	19-23	mitochondrially encoded cytochrome b	Homo sapiens	120-132
7459282-4	1981	The effect of erythropoietin, with or without transferrin-iron is blocked by pre-incubation of the erythropoietin with rabbit anti erythropoietin serum.	Iron	58-62	transferrin	Mus musculus	46-57
24225591-6	2013	At 10 wt.% Fe loading, the catalyst which was calcined at 200 C and no reduced with H2 had the highest activity.	Iron	11-13	relaxin 2	Homo sapiens	84-86
24225591-7	2013	An additional reduction peak which was indicated by H2-TPR in the range of 200-250 C (beside Pd oxide and Fe2O3) was detected in Pd-Fe-PATP catalyst when Fe content was 10 wt.%.	Iron	106-108	relaxin 2	Homo sapiens	52-58
24142925-6	2013	Molecular validation experiments pinpointed the iron metabolism factors AFT1, CCC1, and YAP5 as contributors to these molecular and cellular phenotypes; in genome-scale sequence analyses, a suite of iron toxicity response genes showed evidence for rapid protein evolution in Malaysian yeast.	Iron	48-52	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	72-76
7316222-9	1981	The importance of one of the glycoprotein components of the histiotroph, uteroferrin, is discussed in connection with iron transfer from mother to the fetus.	Iron	118-122	acid phosphatase 5, tartrate resistant	Sus scrofa	73-84
24142925-6	2013	Molecular validation experiments pinpointed the iron metabolism factors AFT1, CCC1, and YAP5 as contributors to these molecular and cellular phenotypes; in genome-scale sequence analyses, a suite of iron toxicity response genes showed evidence for rapid protein evolution in Malaysian yeast.	Iron	48-52	Ccc1p	Saccharomyces cerevisiae S288C	78-82
24142925-6	2013	Molecular validation experiments pinpointed the iron metabolism factors AFT1, CCC1, and YAP5 as contributors to these molecular and cellular phenotypes; in genome-scale sequence analyses, a suite of iron toxicity response genes showed evidence for rapid protein evolution in Malaysian yeast.	Iron	199-203	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	72-76
24142925-6	2013	Molecular validation experiments pinpointed the iron metabolism factors AFT1, CCC1, and YAP5 as contributors to these molecular and cellular phenotypes; in genome-scale sequence analyses, a suite of iron toxicity response genes showed evidence for rapid protein evolution in Malaysian yeast.	Iron	199-203	Ccc1p	Saccharomyces cerevisiae S288C	78-82
6257307-6	1980	This is consistent with a separation of at least 1.5-2.0 nm between the iron atom of cytochrome c and the iron atom of cytochrome c peroxidase.	Iron	72-76	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	119-142
24245933-4	2013	The results demonstrate that Gd(3+)/[Fe(CN)6](3-) nanoparticles have r1p and r2p relaxivities about four times higher than the values observed in the same conditions for the commercial Contrast Agents (CAs) ProHance or Omniscan, regardless of the stabilizing agent used, while nanoparticles of Prussian blue and its analogues M(2+)/[Fe(CN)6](3-) (M = Ni, Cu, Fe) present relatively modest values.	Iron	37-39	CD1e molecule	Homo sapiens	77-80
6257307-6	1980	This is consistent with a separation of at least 1.5-2.0 nm between the iron atom of cytochrome c and the iron atom of cytochrome c peroxidase.	Iron	106-110	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	119-142
24100161-7	2013	We also observed that CTH2, a gene involved in the mRNA degradation of several iron-containing enzymes, was induced upon Yfh1 depletion.	Iron	79-83	ferroxidase	Saccharomyces cerevisiae S288C	121-125
6776357-9	1980	With iron-supplemented microsomes from rat liver, the compounds formed were qualitatively and quantitatively the same as with soybean lipoxygenase, whereas with 18,000 X g rat liver supernatant fractions the yields of all products formed--except 7 alpha-hydroxycholesterol and 6 beta-hydroxy-4-cholesten-3-one--were markedly decreased.	Iron	5-9	linoleate 9S-lipoxygenase-4	Glycine max	134-146
23983135-10	2013	Heme iron intake was associated with an increased risk of colorectal tumors harboring G&gt;A transitions in KRAS and APC and overexpression of P53.	Iron	5-9	KRAS proto-oncogene, GTPase	Homo sapiens	108-112
518870-8	1979	There are two possible implications of this result: (1) the iron atom spin state is not the only major factor in the determination of its position with respect to the heme plane or (2) the change with conformation of the protein force exerted by the proximal histidine on the iron atom (for an iron to heme-plane displacement of less than 0.3 A) is less than 50% of that expected from simple models in which this motion is responsible for cooperativity.	Iron	60-64	spindlin 1	Homo sapiens	70-74
23962819-1	2013	Regulation of iron metabolism in Saccharomyces cerevisiae is achieved at the transcriptional level by low (Aft1 and Aft2) and high iron-sensing (Yap5) transcription factors, and at the post-transcriptional level by mRNA-binding proteins (Cth1 and Cth2).	Iron	14-18	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	107-111
518870-8	1979	There are two possible implications of this result: (1) the iron atom spin state is not the only major factor in the determination of its position with respect to the heme plane or (2) the change with conformation of the protein force exerted by the proximal histidine on the iron atom (for an iron to heme-plane displacement of less than 0.3 A) is less than 50% of that expected from simple models in which this motion is responsible for cooperativity.	Iron	276-280	spindlin 1	Homo sapiens	70-74
24176932-0	2013	Loss of iron triggers PINK1/Parkin-independent mitophagy.	Iron	8-12	PTEN induced kinase 1	Homo sapiens	22-27
518870-8	1979	There are two possible implications of this result: (1) the iron atom spin state is not the only major factor in the determination of its position with respect to the heme plane or (2) the change with conformation of the protein force exerted by the proximal histidine on the iron atom (for an iron to heme-plane displacement of less than 0.3 A) is less than 50% of that expected from simple models in which this motion is responsible for cooperativity.	Iron	276-280	spindlin 1	Homo sapiens	70-74
225201-0	1979	The stoichiometry of the iron-sulphur clusters 1a, 1b and 2 of NADH:Q oxidoreductase as present in beef-heart submitochondrial particles.	Iron	25-29	thioredoxin reductase 1	Homo sapiens	70-84
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	195-199
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	NADPH dehydrogenase	Saccharomyces cerevisiae S288C	234-238
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	291-295
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	31-35	ATP-binding cassette transporter SNQ2	Saccharomyces cerevisiae S288C	304-308
37005-0	1979	A highly sensitive, simple determination of serum iron using chromazurol B.	Iron	50-54	neural proliferation, differentiation and control 1	Homo sapiens	61-74
24074273-5	2013	The oxidative stress response, iron homeostasis, detoxification through PDR transport and direct lipid beta-oxidation were evident through the induction of the genes encoding for peroxiredoxins (GPX2, TSA2), the NADPH:oxidoreductase (OYE3), iron uptake (FIT2, ARN2, FET3), PDR transporters (PDR5, PDR15, SNQ2) and beta-oxidation machinery (FAA2, POX1).	Iron	241-245	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	195-199
24074273-8	2013	Deletion of either of the iron homeostasis regulators AFT1 or AFT2 also resulted in sensitivity to LoaOOH.	Iron	26-30	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	54-58
24089420-0	2013	Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells.	Iron	81-85	RoBo-1	Rattus norvegicus	0-28
24089420-0	2013	Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells.	Iron	81-85	RoBo-1	Rattus norvegicus	30-34
24089420-0	2013	Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells.	Iron	127-131	RoBo-1	Rattus norvegicus	0-28
24089420-0	2013	Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells.	Iron	127-131	RoBo-1	Rattus norvegicus	30-34
24089420-4	2013	Given this possibility and that Dmt1 expression is upregulated by iron deprivation, we sought to test the hypothesis that Dmt1 transports copper during iron deficiency.	Iron	66-70	RoBo-1	Rattus norvegicus	32-36
24089420-8	2013	The control diet-fed +/b rats had normal hematological parameters, whereas iron-deprived +/b and b/b rats were iron deficient and Dmt1 mRNA and protein levels increased.	Iron	75-79	RoBo-1	Rattus norvegicus	130-134
24089420-11	2013	Dmt1 transcript stabilization due to a 3" iron-responsive element was also documented, likely contributing to increased transport activity.	Iron	42-46	RoBo-1	Rattus norvegicus	0-4
24089420-12	2013	In summary, these studies suggest that Dmt1 enhances copper uptake into duodenal enterocytes during iron deprivation.	Iron	100-104	RoBo-1	Rattus norvegicus	39-43
597281-0	1977	Effects of iron status on delta-aminolevulinic acid dehydratase activity.	Iron	11-15	aminolevulinate dehydratase	Homo sapiens	26-63
24126888-5	2013	Iron overload also led to induction of unfolded protein response (XBP1 splicing, activation of IRE-1alpha and PERK, as well as sequestration of GRP78) and ER stress (increased CHOP protein expression) following HFD and ethanol.	Iron	0-4	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	110-114
889717-4	1977	Iron transport, determined by measurement of the rate of 59Fe uptake from 59Fe-labelled transferrin, was proportional to the number of receptors at all stages of differentiation.	Iron	0-4	transferrin	Mus musculus	88-99
22985600-2	2013	Based on X-ray crystallographic studies of cytochrome bc1, a mechanism has been proposed in which the extrinsic domain of the iron-sulfur protein first binds to cytochrome b where it accepts an electron from ubiquinol in the Qo site, and then rotates by 57  to a position close to cytochrome c1 where it transfers an electron to cytochrome c1.	Iron	126-130	mitochondrially encoded cytochrome b	Homo sapiens	43-55
931497-1	1977	The relation ship between the quantities of soluble iron and iron available for humans reported by other authors in seven different vegetable foods was investigated.	Iron	52-56	inositol polyphosphate-5-phosphatase D	Homo sapiens	13-17
23994517-6	2013	The greatest increase in muscle iron content occurred during the period of animal growth and was associated with downregulation of TfR1 and IRP2 expression.	Iron	32-36	iron responsive element binding protein 2	Rattus norvegicus	140-144
23750037-8	2013	Recently, novel iron chelators with selective antitumour activity (ie, Dp44mT, DpC) were shown to upregulate NDRG1 in cancer cells.	Iron	16-20	N-myc downstream regulated 1	Homo sapiens	109-114
18962037-1	1977	The uranium present in the leach liquors obtained by attack on phosphate rock with sulphuric acid can be extracted with di(2-ethylhexyl)phosphoric acid and TBP after oxidation of any iron(II), and then stripped at 65 degrees with iron(II) in 8.6M phosphoric acid.	Iron	183-187	TATA-box binding protein	Homo sapiens	156-159
24030826-0	2013	The functional interaction of mitochondrial Hsp70s with the escort protein Zim17 is critical for Fe/S biogenesis and substrate interaction at the inner membrane preprotein translocase.	Iron	97-99	Zim17p	Saccharomyces cerevisiae S288C	75-80
836897-8	1977	Pretreatment of the rats with the iron chelator, Desferal, causes a 3-4-fold increase in hemopexin but not in albumin and transferrin synthesis.	Iron	34-38	hemopexin	Rattus norvegicus	89-98
24155934-3	2013	This model of iron sensing which centers upon the requirement for an interaction between HFE and TFR2 has recently been questioned with in vivo studies in mice from our laboratory and others which suggest that Hfe and Tfr2 can regulate hepcidin independently of each other.	Iron	14-18	homeostatic iron regulator	Mus musculus	89-92
24155934-3	2013	This model of iron sensing which centers upon the requirement for an interaction between HFE and TFR2 has recently been questioned with in vivo studies in mice from our laboratory and others which suggest that Hfe and Tfr2 can regulate hepcidin independently of each other.	Iron	14-18	transferrin receptor 2	Mus musculus	97-101
186485-0	1976	Functional and physicochemical studies of hemoglobin St. Louis beta 28 (B10) Leu replaced by Gln: a variant with ferric beta heme iron.	Iron	130-134	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	72-75
24155934-3	2013	This model of iron sensing which centers upon the requirement for an interaction between HFE and TFR2 has recently been questioned with in vivo studies in mice from our laboratory and others which suggest that Hfe and Tfr2 can regulate hepcidin independently of each other.	Iron	14-18	homeostatic iron regulator	Mus musculus	210-213
24155934-3	2013	This model of iron sensing which centers upon the requirement for an interaction between HFE and TFR2 has recently been questioned with in vivo studies in mice from our laboratory and others which suggest that Hfe and Tfr2 can regulate hepcidin independently of each other.	Iron	14-18	transferrin receptor 2	Mus musculus	218-222
24155934-3	2013	This model of iron sensing which centers upon the requirement for an interaction between HFE and TFR2 has recently been questioned with in vivo studies in mice from our laboratory and others which suggest that Hfe and Tfr2 can regulate hepcidin independently of each other.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	236-244
178656-1	1976	In addition to the two species of ferredoxin-type iron-sulfur centers (Centers S-1 and S-2), a third iron-sulfur center (Center S-3), which is paramagnetic in the oxidezed state analogous to the bacterial high potential iron-sulfur protein, has bwen detected in the reconstitutively active soluble succinate dehydrogenase preparation.	Iron	101-105	ribosomal protein S3	Homo sapiens	128-131
24160625-0	2013	Spin excitations of individual Fe atoms on Pt(111): impact of the site-dependent giant substrate polarization.	Iron	31-33	spindlin 1	Homo sapiens	0-4
24007662-8	2013	The elevation of ferritin (FTL, FTH1) may indicate an iron-mediated oxidative imbalance aggravating the mitochondrial failure and neurotoxicity.	Iron	54-58	ferritin light chain	Homo sapiens	27-30
178656-1	1976	In addition to the two species of ferredoxin-type iron-sulfur centers (Centers S-1 and S-2), a third iron-sulfur center (Center S-3), which is paramagnetic in the oxidezed state analogous to the bacterial high potential iron-sulfur protein, has bwen detected in the reconstitutively active soluble succinate dehydrogenase preparation.	Iron	101-105	ribosomal protein S3	Homo sapiens	128-131
23897214-5	2013	However, reactions carried out under similar conditions with MSO4 (M = Co and Fe) led to the isolation of two [M2(mu-Bz)2(mu-pyz)2(Bz)2] (HBz) isostructural infinite 1D ladder chains (M = Co (3) and M = Fe (4)).	Iron	78-80	hemoglobin subunit zeta	Homo sapiens	138-141
1250760-0	1976	[Effect of spa treatment on the levels of serum iron and transferrin in electric welders].	Iron	48-52	surfactant protein A2	Homo sapiens	11-14
24215875-12	2013	CONCLUSION: Findings from our study provides new understandings about the relative expression, regulation by iron and correlation among the mRNA expressions of transferrin receptors 1 and 2, divalent metal transporter 1, ferritin, iron regulation proteins 1 and 2, hereditary hemochromatosis protein, hepcidin, ferroportin 1 and hephaestin in intestine, liver, spleen, kidney, heart, and lung of rat.	Iron	109-113	transferrin receptor 2	Rattus norvegicus	160-189
1250860-6	1976	When transferrin-bound iron is given to polycythemic mice, this iron is also deposited in parenchymal cells of the liver and is also less available for new hemoglobin synthesis.	Iron	23-27	transferrin	Mus musculus	5-16
23857908-2	2013	Exome sequencing revealed a homozygous missense variant (c.187G>C; p.Ala63Pro) in C19orf12, a gene recently implicated in neurodegeneration with brain iron accumulation (NBIA).	Iron	151-155	chromosome 19 open reading frame 12	Homo sapiens	82-90
24086573-1	2013	Hepcidin is the principal iron regulatory hormone, controlling the systemic absorption and remobilization of iron from intracellular stores.	Iron	26-30	hepcidin antimicrobial peptide	Mus musculus	0-8
24086573-1	2013	Hepcidin is the principal iron regulatory hormone, controlling the systemic absorption and remobilization of iron from intracellular stores.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	0-8
1250860-6	1976	When transferrin-bound iron is given to polycythemic mice, this iron is also deposited in parenchymal cells of the liver and is also less available for new hemoglobin synthesis.	Iron	64-68	transferrin	Mus musculus	5-16
807277-6	1975	These results support the hypothesis of a generalized impairment of cellular iron uptake in hereditary microcytic anemia and suggest that there might be a defect in red cell receptor sites for transferrin in this condition.	Iron	77-81	transferrin	Mus musculus	193-204
23179203-0	2013	Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity.	Iron	150-154	STEAP4 metalloreductase	Homo sapiens	0-50
23179203-0	2013	Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity.	Iron	150-154	lipocalin 2	Homo sapiens	55-97
23179203-1	2013	PURPOSE: Six-transmembrane epithelial antigen of prostate (STEAP)-4 and neutrophil gelatinase-associated lipocalin (NGAL) are novel adipokines related to iron homeostasis with potential roles in insulin resistance and inflammation.	Iron	154-158	STEAP4 metalloreductase	Homo sapiens	9-67
23179203-1	2013	PURPOSE: Six-transmembrane epithelial antigen of prostate (STEAP)-4 and neutrophil gelatinase-associated lipocalin (NGAL) are novel adipokines related to iron homeostasis with potential roles in insulin resistance and inflammation.	Iron	154-158	lipocalin 2	Homo sapiens	72-114
23179203-1	2013	PURPOSE: Six-transmembrane epithelial antigen of prostate (STEAP)-4 and neutrophil gelatinase-associated lipocalin (NGAL) are novel adipokines related to iron homeostasis with potential roles in insulin resistance and inflammation.	Iron	154-158	lipocalin 2	Homo sapiens	116-120
23179203-2	2013	The aim of the present work was to evaluate the effect of obesity and iron status on gene expression levels of STEAP-4 and NGAL in visceral adipose tissue (VAT) and its implication in inflammation.	Iron	70-74	STEAP4 metalloreductase	Homo sapiens	111-118
165977-0	1975	Properties of the S-3 iron-sulphur centre of succinate dehydrogenase in the intact respiratory chain of beef heart mitochondria.	Iron	22-26	ribosomal protein S3	Homo sapiens	18-21
23179203-2	2013	The aim of the present work was to evaluate the effect of obesity and iron status on gene expression levels of STEAP-4 and NGAL in visceral adipose tissue (VAT) and its implication in inflammation.	Iron	70-74	lipocalin 2	Homo sapiens	123-127
23772810-13	2013	More importantly, N-acetyl-L-cysteine (NAC) or DFO could partially attenuate cell injury and inhibit the signaling pathway induced by excessive iron.	Iron	144-148	X-linked Kx blood group	Homo sapiens	39-42
234444-11	1975	Changes in the reactivity of the beta93 sulfhydryl group of methemoglobin also accompany addition of IHP, but in a manner which is largely independent of the spin state of the iron.	Iron	176-180	hemoglobin subunit gamma 2	Homo sapiens	60-73
24409694-2	2013	FXN is a mitochondrial protein which plays an important role in the regulation of intracellular iron trafficking, biogenesis of iron-sulfur cluster and heme, and removal of reactive oxygen species.	Iron	96-100	frataxin	Mus musculus	0-3
24409694-2	2013	FXN is a mitochondrial protein which plays an important role in the regulation of intracellular iron trafficking, biogenesis of iron-sulfur cluster and heme, and removal of reactive oxygen species.	Iron	128-132	frataxin	Mus musculus	0-3
5495537-0	1970	[Effect of iron-containing mineral waters at Krynica spa on serum iron level].	Iron	11-15	surfactant protein A2	Homo sapiens	53-56
23969461-7	2013	Our results include the striking finding that the triple point of the metallic phase and two insulating phases is at the transition temperature, Ttr = Tc, which we determine to be 65.0 +- 0.1  C. The findings have profound implications for the mechanism of the metal-insulator transition in VO2, but they also demonstrate the importance of this approach for mastering phase transitions in many other strongly correlated materials, such as manganites and iron-based superconductors.	Iron	454-458	transthyretin	Homo sapiens	145-148
5495537-0	1970	[Effect of iron-containing mineral waters at Krynica spa on serum iron level].	Iron	66-70	surfactant protein A2	Homo sapiens	53-56
5480860-14	1970	The binding of cyanide to the iron atom in methemoglobin is thought to be associated with increased planarity of the heme group and increased stability of the heme-globin complex.	Iron	30-34	hemoglobin subunit gamma 2	Homo sapiens	43-56
5858016-2	1965	Iron bacteria in tap water and in the sediment of pipes system].	Iron	0-4	nuclear RNA export factor 1	Homo sapiens	17-20
23941109-4	2013	Moreover, BDH2 catalyzes the production of 2, 3-DHBA during enterobactin biosynthesis and participates in 24p3 (LCN2)-mediated iron transport and apoptosis.	Iron	127-131	lipocalin 2	Homo sapiens	112-116
19872729-2	1933	Both of these ions appear to combine with the iron of the methemoglobin molecule and reduce its oxidant activity.	Iron	46-50	hemoglobin subunit gamma 2	Homo sapiens	58-71
23668485-8	2013	The expression of hepcidin, which regulates tissue accumulation and mobilization of iron, was increased in the skin and lungs of Cl2-exposed mice.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	18-26
23791636-10	2013	In the presence of ATK (cPLA2 inhibitor) and YM 26734 (sPLA2 inhibitor), the nuclear localization of both p65 and p50 NF-kappaB subunits was restored to control levels in retinas exposed to iron-induced oxidative stress.	Iron	190-194	phospholipase A2 group IVA	Homo sapiens	24-29
16744793-0	1932	Iron in relation to tyrosinase.	Iron	0-4	tyrosinase	Homo sapiens	20-30
23508576-2	2013	DMT1 is also present in the liver, where it has been implicated in the uptake of transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload.	Iron	99-103	transferrin	Mus musculus	81-92
33839281-3	2021	In this study we investigated whether the feeding of an iron deficient/HCD to Hfe-/- mice influenced the development of NAFLD.	Iron	56-60	homeostatic iron regulator	Mus musculus	78-81
23505057-2	2013	Through unknown mechanisms, certain intravenous iron preparations induce acute, reversible increases in circulating FGF23 levels that lower serum phosphate in association with inappropriately low levels of calcitriol, similar to genetic diseases of primary FGF23 excess.	Iron	48-52	fibroblast growth factor 23	Homo sapiens	116-121
33319934-0	2021	Silencing of lipocalin-2 improves cardiomyocyte viability under iron overload conditions via decreasing mitochondrial dysfunction and apoptosis.	Iron	64-68	lipocalin 2	Homo sapiens	13-24
23505057-2	2013	Through unknown mechanisms, certain intravenous iron preparations induce acute, reversible increases in circulating FGF23 levels that lower serum phosphate in association with inappropriately low levels of calcitriol, similar to genetic diseases of primary FGF23 excess.	Iron	48-52	fibroblast growth factor 23	Homo sapiens	257-262
23505057-4	2013	We tested the association of iron deficiency anemia with C-terminal FGF23 (cFGF23) and intact FGF23 (iFGF23) levels in 55 women with a history of heavy uterine bleeding, and assessed the longitudinal biochemical response over 35 days to equivalent doses of randomly-assigned, intravenous elemental iron in the form of ferric carboxymaltose (FCM) or iron dextran.	Iron	29-33	fibroblast growth factor 23	Homo sapiens	68-73
23505057-4	2013	We tested the association of iron deficiency anemia with C-terminal FGF23 (cFGF23) and intact FGF23 (iFGF23) levels in 55 women with a history of heavy uterine bleeding, and assessed the longitudinal biochemical response over 35 days to equivalent doses of randomly-assigned, intravenous elemental iron in the form of ferric carboxymaltose (FCM) or iron dextran.	Iron	29-33	fibroblast growth factor 23	Homo sapiens	76-81
23505057-10	2013	We propose that intravenous iron lowers cFGF23 in humans by reducing fgf23 transcription as it does in mice, whereas carbohydrate moieties in certain iron preparations may simultaneously inhibit FGF23 degradation in osteocytes leading to transient increases in iFGF23 and reduced serum phosphate.	Iron	28-32	fibroblast growth factor 23	Homo sapiens	69-74
33319934-1	2021	This study aimed to investigate the mechanistic roles of LCN-2 and LCN-2 receptors (LCN-2R) as iron transporters in cardiomyocytes under iron overload condition.	Iron	95-99	lipocalin 2	Homo sapiens	57-62
23505057-10	2013	We propose that intravenous iron lowers cFGF23 in humans by reducing fgf23 transcription as it does in mice, whereas carbohydrate moieties in certain iron preparations may simultaneously inhibit FGF23 degradation in osteocytes leading to transient increases in iFGF23 and reduced serum phosphate.	Iron	28-32	fibroblast growth factor 23	Mus musculus	41-46
33319934-1	2021	This study aimed to investigate the mechanistic roles of LCN-2 and LCN-2 receptors (LCN-2R) as iron transporters in cardiomyocytes under iron overload condition.	Iron	137-141	lipocalin 2	Homo sapiens	57-62
33319934-4	2021	Silencing of lipocalin-2 or its receptor improved cardiomyocyte viability via decreasing iron uptake, mitochondrial fission, mitophagy and cleaved caspase-3 only in the Fe3+ overload condition.	Iron	89-93	lipocalin 2	Homo sapiens	13-24
33507490-2	2021	Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintaining iron homeostasis.	Iron	184-188	ferritin light chain	Homo sapiens	111-131
23864114-6	2013	Genome wide transcriptional profiling revealed a constitutive activation of the iron regulon that could be accounted for by a constitutive nuclear localization of the transcriptional activator Aft1.	Iron	80-84	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	193-197
23723143-7	2013	In addition, AAV-ADIPOQ-treated iron-overload mice had lower expression of inflammatory markers, including myeloperoxidase activity, monocyte chemotactic protein-1, tumor necrosis factor-alpha, interleukin-6, and intercellular adhesion molecule-1, than iron-overloaded mice not treated with AAV-ADIPOQ.	Iron	32-36	myeloperoxidase	Mus musculus	107-122
23723143-7	2013	In addition, AAV-ADIPOQ-treated iron-overload mice had lower expression of inflammatory markers, including myeloperoxidase activity, monocyte chemotactic protein-1, tumor necrosis factor-alpha, interleukin-6, and intercellular adhesion molecule-1, than iron-overloaded mice not treated with AAV-ADIPOQ.	Iron	32-36	chemokine (C-C motif) ligand 2	Mus musculus	133-192
33507490-2	2021	Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintaining iron homeostasis.	Iron	184-188	ferritin light chain	Homo sapiens	133-136
23834908-0	2013	Iron bioavailability of maize hemoglobin in a Caco-2 cell culture model.	Iron	0-4	non-symbiotic hemoglobin	Zea mays	30-40
33998640-6	2021	Upon introducing Fe species onto the Ni3S2/NF electrode by a simple dipping/drying method, the intrinsic OER activity can be extremely improved.	Iron	17-19	neurofascin	Homo sapiens	43-45
23834908-2	2013	Hemoglobin is a form of iron that is highly bioavailable, and its bioavailability is not inhibited by phytate.	Iron	24-28	non-symbiotic hemoglobin	Zea mays	0-10
23834908-3	2013	It was hypothesized that maize hemoglobin is a highly bioavailable iron source and that biofortification of maize with iron can be accomplished by overexpression of maize globin in the endosperm.	Iron	67-71	non-symbiotic hemoglobin	Zea mays	31-41
23834908-5	2013	Iron bioavailability of maize hemoglobin produced in Escherichia coli and of stably transformed seeds expressing the maize globin-GFP fusion was determined using an in vitro Caco-2 cell culture model.	Iron	0-4	non-symbiotic hemoglobin	Zea mays	30-40
23834908-6	2013	Maize flour fortified with maize hemoglobin was found to have iron bioavailability that is not significantly different from that of flour fortified with ferrous sulfate or bovine hemoglobin but is significantly higher than unfortified flour.	Iron	62-66	non-symbiotic hemoglobin	Zea mays	33-43
33983035-1	2021	We disclose herein the first example of iron-catalyzed regioselective intramolecular C-H/B-H dehydrogenative coupling, affording unprecedented C,B-substituted carborane-fused phenanthroline derivatives.	Iron	40-44	bleomycin hydrolase	Homo sapiens	89-92
23898337-4	2013	This review focuses on the new actors discovered in the past few years, such as glutaredoxin, BOLA and NEET proteins as well as MIP18, MMS19, TAH18, DRE2 for the cytosolic machinery, which are integrated into a model for the plant Fe-S cluster biogenesis systems.	Iron	231-235	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	135-140
23743663-0	2013	Spin state modulation of iron spin crossover complexes via hydrogen-bonding self-assembly.	Iron	25-29	spindlin 1	Homo sapiens	0-4
23743663-0	2013	Spin state modulation of iron spin crossover complexes via hydrogen-bonding self-assembly.	Iron	25-29	spindlin 1	Homo sapiens	30-34
33991530-0	2021	The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	11-19
23743663-1	2013	Iron complexes derived from 6-diaminotriazyl-2,2"-bipyridines display spin crossover behaviour, and hydrogen bonding-controlled self-assembly with a suitable barbiturate partner can modulate the crossover from mixed low and high spin to high spin.	Iron	0-4	spindlin 1	Homo sapiens	70-74
23743663-1	2013	Iron complexes derived from 6-diaminotriazyl-2,2"-bipyridines display spin crossover behaviour, and hydrogen bonding-controlled self-assembly with a suitable barbiturate partner can modulate the crossover from mixed low and high spin to high spin.	Iron	0-4	spindlin 1	Homo sapiens	229-233
23743663-1	2013	Iron complexes derived from 6-diaminotriazyl-2,2"-bipyridines display spin crossover behaviour, and hydrogen bonding-controlled self-assembly with a suitable barbiturate partner can modulate the crossover from mixed low and high spin to high spin.	Iron	0-4	spindlin 1	Homo sapiens	229-233
23687303-5	2013	Levels of phospho-FoxO3a (inactive form) increased in the cytosolic fraction of cells treated with iron in a PI3K-dependent manner.	Iron	99-103	forkhead box O3	Mus musculus	18-24
33951946-1	2021	Lipocalin-2 mediates neuro-inflammation and iron homeostasis in vascular injuries of the central nervous system (CNS) and is upregulated in extra-CNS systemic inflammation.	Iron	44-48	lipocalin 2	Homo sapiens	0-11
23636690-6	2013	However, we have found that leuC and leuD, encoding the heterodimeric iron-sulfur cluster protein, isopropylmalate isomerase, can complement the S. cerevisiae leu1 auxotrophy.	Iron	70-74	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	159-163
23940826-6	2013	In addition we have extended our immunohistochemical studies to a second cohort of pigeons, confirming that iron rich cells in the upper beak are positive for MHCII and CD44, which are expressed by macrophages.	Iron	108-112	CD44 molecule (Indian blood group)	Homo sapiens	169-173
33848160-5	2021	It experiences a spin-glass transition around 480 K. With further Os substitution up to x = 2, the crystal symmetry changes to Pn3, where Fe and Os are orderly distributed in a rocksalt-type fashion at the B site.	Iron	138-140	sodium voltage-gated channel alpha subunit 10	Homo sapiens	127-130
23580428-6	2013	In conclusion, we provide evidence that core+1/ARFP downregulates AP1-mediated transcription, providing new insights into the biological role of core+1/ARFP, as well as the transcriptional modulation of hepcidin, the main regulator of iron metabolism.	Iron	235-239	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-69
23620481-0	2013	AtHO1 is involved in iron homeostasis in an NO-dependent manner.	Iron	21-25	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	0-5
33471363-2	2021	Phosphorus homeostasis can be affected by diet and certain medications; some intravenous iron formulations can induce renal phosphate excretion and hypophosphatemia, likely through increasing serum concentrations of intact fibroblast growth factor 23.	Iron	89-93	fibroblast growth factor 23	Homo sapiens	223-250
23620481-1	2013	AtHO1 (HY1) encodes heme oxygenase-1 in Arabidopsis, catalyzing cleavage of heme to biliverdin with the release of iron and carbon monoxide (CO).	Iron	115-119	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	0-5
23620481-1	2013	AtHO1 (HY1) encodes heme oxygenase-1 in Arabidopsis, catalyzing cleavage of heme to biliverdin with the release of iron and carbon monoxide (CO).	Iron	115-119	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	7-10
23620481-1	2013	AtHO1 (HY1) encodes heme oxygenase-1 in Arabidopsis, catalyzing cleavage of heme to biliverdin with the release of iron and carbon monoxide (CO).	Iron	115-119	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	20-36
23620481-5	2013	Evidence has been provided that overexpression of AtHO1 could confer plant tolerance to iron deficiency by improving expression of AtFIT, AtFRO2 and AtIRT1, the activity of ferric-chelate reductase (FCR) and iron accumulation.	Iron	88-92	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	50-55
23620481-7	2013	In 35S::AtHO1 transgenic lines, a higher level of CO and water-soluble iron, and a lower level of heme were identified, suggesting that AtHO1-regulated iron homeostasis was possibly through the catabolism of heme to produce CO and free iron.	Iron	71-75	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	136-141
33835366-1	2021	The hormone hepcidin plays a central role in controlling iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	12-20
23620481-7	2013	In 35S::AtHO1 transgenic lines, a higher level of CO and water-soluble iron, and a lower level of heme were identified, suggesting that AtHO1-regulated iron homeostasis was possibly through the catabolism of heme to produce CO and free iron.	Iron	152-156	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	8-13
23620481-7	2013	In 35S::AtHO1 transgenic lines, a higher level of CO and water-soluble iron, and a lower level of heme were identified, suggesting that AtHO1-regulated iron homeostasis was possibly through the catabolism of heme to produce CO and free iron.	Iron	152-156	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	136-141
23620481-7	2013	In 35S::AtHO1 transgenic lines, a higher level of CO and water-soluble iron, and a lower level of heme were identified, suggesting that AtHO1-regulated iron homeostasis was possibly through the catabolism of heme to produce CO and free iron.	Iron	152-156	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	8-13
23620481-7	2013	In 35S::AtHO1 transgenic lines, a higher level of CO and water-soluble iron, and a lower level of heme were identified, suggesting that AtHO1-regulated iron homeostasis was possibly through the catabolism of heme to produce CO and free iron.	Iron	152-156	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	136-141
33835366-2	2021	Iron-mediated hepcidin synthesis is triggered via the BMP/SMAD pathway.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	14-22
23620481-12	2013	These results suggest that AtHO1 is involved in iron homeostasis in an NO-dependent manner.	Iron	48-52	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	27-32
33464620-7	2021	Either Cu supplement or overexpression of COPT2 or FRO4 improves the growth of fit-2 under Fe deficiency conditions.	Iron	91-93	copper transporter 2	Arabidopsis thaliana	42-47
23692052-5	2013	Zinc K-edge XAS has been performed on the resting JMJD2A (with iron in the active site) to confirm the presence of the expected structural zinc site.	Iron	63-67	lysine demethylase 4A	Homo sapiens	50-56
33464620-9	2021	This work through the link between bHLH Ib/FIT and COPT2/FRO4/FRO5 under Fe deficiency conditions establishes a new relationship between Cu and Fe homeostasis.	Iron	73-75	copper transporter 2	Arabidopsis thaliana	51-56
33464620-9	2021	This work through the link between bHLH Ib/FIT and COPT2/FRO4/FRO5 under Fe deficiency conditions establishes a new relationship between Cu and Fe homeostasis.	Iron	73-75	ferric reduction oxidase 5	Arabidopsis thaliana	62-66
33895792-2	2021	In response to either increased iron or inflammation, hepatocyte-secreted hepcidin binds to FPN, inducing its internalization and subsequent degradation.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	74-82
23594612-6	2013	However, ethanol exposure led to significant decreases in hepatic content of ferric iron and gene expression of the iron-regulating hormone hepcidin and tumor necrosis factor (TNF)-alpha (all P &lt; 0.05).	Iron	116-120	hepcidin	Ovis aries	140-148
23594612-9	2013	We conclude that daily ethanol exposure during the third-trimester-equivalent in sheep does not alter fetal liver morphology; however, decreased fetal liver ferric iron content and altered hepcidin and ferroportin gene expression indicate that iron homeostasis is altered.	Iron	244-248	hepcidin	Ovis aries	189-197
23541988-3	2013	METHODS: These observations could be mimicked by utilizing purified GAPDH injected into mice as well as when supplemented in culture medium of model cell lines and primary cell types that play a key role in iron metabolism.	Iron	207-211	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	68-73
33895792-6	2021	Interestingly, loss of Tet1 expression causes an accumulation of FPN and an impaired response to iron overload, manifested by increased iron accumulation in the liver together with decreased iron in the spleen and duodenum.	Iron	97-101	tet methylcytosine dioxygenase 1	Mus musculus	23-27
23538201-10	2013	Hepatic mRNA expression of transferrin receptor 1 and 2, ferritins, and hepcidin were increased more in CE than C, and more in HE than H. In the duodenum, divalent metal transporter 1, ferritin H, and hephaestin mRNA levels were increased in CE compared with C. In experiment 2, hepatic iron concentrations were higher in HIE than HI.	Iron	287-291	transferrin receptor 2	Mus musculus	27-55
33895792-6	2021	Interestingly, loss of Tet1 expression causes an accumulation of FPN and an impaired response to iron overload, manifested by increased iron accumulation in the liver together with decreased iron in the spleen and duodenum.	Iron	136-140	tet methylcytosine dioxygenase 1	Mus musculus	23-27
33895792-6	2021	Interestingly, loss of Tet1 expression causes an accumulation of FPN and an impaired response to iron overload, manifested by increased iron accumulation in the liver together with decreased iron in the spleen and duodenum.	Iron	136-140	tet methylcytosine dioxygenase 1	Mus musculus	23-27
23987010-4	2013	Two kinds of HNE-1 and CNE-2 cells and implanted tumors phagocytosis of FA-MNP-MMP-9-ASODN were observed by MRI on tumor-bearing nude mice, iron staining and TEM.	Iron	140-144	matrix metallopeptidase 9	Homo sapiens	79-84
33895792-9	2021	These findings suggest that the Tet1-RNF217-FPN axis regulates iron homeostasis, revealing new therapeutic targets for FPN-related diseases.	Iron	63-67	tet methylcytosine dioxygenase 1	Mus musculus	32-36
23335088-1	2013	BACKGROUND: Growth differentiation factor 15 (GDF15), a divergent TGFbeta superfamily, has recently been implicated in the modulation of iron homeostasis, acting as an upstream negative regulator of hepcidin, the key iron regulatory hormone produced primarily by hepatocytes.	Iron	137-141	growth differentiation factor 15	Homo sapiens	12-44
33876884-7	2021	Fe-scaffold was found to promote the cell adhesion compared with Uncoated-scaffold, including increasing the adhered cell number, promoting cell spreading and upregulating the expression levels of adhesion-related genes integrin alpha1 and beta1 and their downstream signaling molecules FAK and ERK1/2 (p < 0.05).	Iron	0-2	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	240-245
23335088-1	2013	BACKGROUND: Growth differentiation factor 15 (GDF15), a divergent TGFbeta superfamily, has recently been implicated in the modulation of iron homeostasis, acting as an upstream negative regulator of hepcidin, the key iron regulatory hormone produced primarily by hepatocytes.	Iron	137-141	growth differentiation factor 15	Homo sapiens	46-51
23335088-1	2013	BACKGROUND: Growth differentiation factor 15 (GDF15), a divergent TGFbeta superfamily, has recently been implicated in the modulation of iron homeostasis, acting as an upstream negative regulator of hepcidin, the key iron regulatory hormone produced primarily by hepatocytes.	Iron	217-221	growth differentiation factor 15	Homo sapiens	12-44
23335088-1	2013	BACKGROUND: Growth differentiation factor 15 (GDF15), a divergent TGFbeta superfamily, has recently been implicated in the modulation of iron homeostasis, acting as an upstream negative regulator of hepcidin, the key iron regulatory hormone produced primarily by hepatocytes.	Iron	217-221	growth differentiation factor 15	Homo sapiens	46-51
23335088-2	2013	However, little is known about possible roles that GDF15 might play in the regulation of iron homeostasis and development of hyperferritinemia in children with hemophagocytic lymphohistiocytosis (HLH).	Iron	89-93	growth differentiation factor 15	Homo sapiens	51-56
33784082-0	2021	Enhancing Chemo- and Stereoselectivity in C-H Bond Oxygenation with H2O2 by Nonheme High-Spin Iron Catalysts: The Role of Lewis Acid and Multimetal Centers.	Iron	94-98	spindlin 1	Homo sapiens	89-93
23717386-5	2013	NAF-1 has shown the unusual abilities to transfer its 2Fe-2S cluster to an apo-acceptor protein (followed in vitro by spectrophotometry and by native PAGE electrophoresis) and to transfer iron to intact mitochondria in cell models (monitored by fluorescence imaging with iron fluorescent sensors targeted to mitochondria).	Iron	188-192	CDGSH iron sulfur domain 2	Homo sapiens	0-5
23717386-5	2013	NAF-1 has shown the unusual abilities to transfer its 2Fe-2S cluster to an apo-acceptor protein (followed in vitro by spectrophotometry and by native PAGE electrophoresis) and to transfer iron to intact mitochondria in cell models (monitored by fluorescence imaging with iron fluorescent sensors targeted to mitochondria).	Iron	271-275	CDGSH iron sulfur domain 2	Homo sapiens	0-5
23704825-0	2013	Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation.	Iron	70-74	heme oxygenase 1	Rattus norvegicus	11-27
33784082-1	2021	Spin states of iron often direct the selectivity in oxidation catalysis by iron complexes using hydrogen peroxide (H2O2) on an oxidant.	Iron	15-19	spindlin 1	Homo sapiens	0-4
23704825-1	2013	AIM: To investigate the effects of the heme oxygenase (HO)-1/carbon monoxide system on iron deposition and portal pressure in rats with hepatic fibrosis induced by bile duct ligation (BDL).	Iron	87-91	heme oxygenase 1	Rattus norvegicus	39-60
33784082-1	2021	Spin states of iron often direct the selectivity in oxidation catalysis by iron complexes using hydrogen peroxide (H2O2) on an oxidant.	Iron	75-79	spindlin 1	Homo sapiens	0-4
33784082-5	2021	The enhanced selectivity for C-H bond hydroxylation catalyzed by the high-spin iron(II) complexes in the presence of Sc3+ parallels that of the low-spin iron catalysts.	Iron	79-83	spindlin 1	Homo sapiens	74-78
23705020-7	2013	Intestinal absorption of (59)Fe was increased and clearance of injected (59)Fe was also increased in Hfe(-/-) mice compared to controls.	Iron	29-31	homeostatic iron regulator	Mus musculus	101-104
23705020-7	2013	Intestinal absorption of (59)Fe was increased and clearance of injected (59)Fe was also increased in Hfe(-/-) mice compared to controls.	Iron	76-78	homeostatic iron regulator	Mus musculus	101-104
33784082-5	2021	The enhanced selectivity for C-H bond hydroxylation catalyzed by the high-spin iron(II) complexes in the presence of Sc3+ parallels that of the low-spin iron catalysts.	Iron	79-83	spindlin 1	Homo sapiens	148-152
33870790-8	2022	In univariable analysis, having >=2 iron rims (vs 0) was associated with increased CSF CHI3L1 levels (beta = 1.41; 95% confidence interval (CI) = 1.10-1.79; p < 0.01) and serum NfL levels (beta = 2.30; 95% CI = 1.47-3.60; p < 0.01).	Iron	36-40	neurofilament light chain	Homo sapiens	177-180
33610598-0	2021	Low anticoagulant heparin-iron complex targeting inhibition of hepcidin ameliorates anemia of chronic disease in rodents.	Iron	26-30	hepcidin antimicrobial peptide	Mus musculus	63-71
23686013-3	2013	Here we review studies on the Divalent Metal Transporter-1 homolog Malvolio (iron import), the recent discovery that Multicopper Oxidase-1 has ferroxidase activity (iron export) and the role of ferritin in the process of iron acquisition (iron storage).	Iron	165-169	Multicopper oxidase 1	Drosophila melanogaster	117-138
23686013-3	2013	Here we review studies on the Divalent Metal Transporter-1 homolog Malvolio (iron import), the recent discovery that Multicopper Oxidase-1 has ferroxidase activity (iron export) and the role of ferritin in the process of iron acquisition (iron storage).	Iron	165-169	Multicopper oxidase 1	Drosophila melanogaster	117-138
23686013-3	2013	Here we review studies on the Divalent Metal Transporter-1 homolog Malvolio (iron import), the recent discovery that Multicopper Oxidase-1 has ferroxidase activity (iron export) and the role of ferritin in the process of iron acquisition (iron storage).	Iron	165-169	Multicopper oxidase 1	Drosophila melanogaster	117-138
23508953-6	2013	Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply.	Iron	79-83	TSC complex subunit 2	Homo sapiens	60-64
33610598-1	2021	Hepcidin is the only known hormone negatively regulates systemic iron availability, its excess contributes to anemia of chronic disease (ACD).Heparin has been shown to be an efficient hepcidin inhibitor both in vitro and in vivo, but its powerful anticoagulant activity limits this therapeutic application.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	0-8
23508953-6	2013	Sustained ISCU protein levels enhanced by mTORC1 sensitized TSC2-null cells to iron deprivation due to constitutive ISC biogenesis-triggered iron demand, which outstrips supply.	Iron	141-145	TSC complex subunit 2	Homo sapiens	60-64
33610598-1	2021	Hepcidin is the only known hormone negatively regulates systemic iron availability, its excess contributes to anemia of chronic disease (ACD).Heparin has been shown to be an efficient hepcidin inhibitor both in vitro and in vivo, but its powerful anticoagulant activity limits this therapeutic application.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	184-192
33920441-4	2021	As the content of Fe impurities increases, the voltage loss of activated carbon with the Fe impurity concentrations of 1.12 wt.% (AF-1.12) decreases by 37.9% of the original, which is attributable to the reduce of ohmic leakage and diffusion, and the increase in Faradic redox at the electrode/electrolyte interface.	Iron	18-20	ephrin A5	Homo sapiens	130-134
23295455-3	2013	Here we report that arsenic activates the iron responsive transcription factor, Aft1, as a consequence of a defective high-affinity iron uptake mediated by Fet3 and Ftr1, whose mRNAs are drastically decreased upon arsenic exposure.	Iron	42-46	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	165-169
23295455-3	2013	Here we report that arsenic activates the iron responsive transcription factor, Aft1, as a consequence of a defective high-affinity iron uptake mediated by Fet3 and Ftr1, whose mRNAs are drastically decreased upon arsenic exposure.	Iron	132-136	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	80-84
33835027-2	2021	Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein import pathway, results in impaired cytosolic Fe/S cluster biogenesis in mammalian cells.	Iron	132-134	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	68-73
33916457-1	2021	Human CISD2 and mitoNEET are two NEET proteins anchored in the endoplasmic reticulum and mitochondria membranes respectively, with an Fe-S containing domain stretching out in the cytosol.	Iron	134-138	CDGSH iron sulfur domain 2	Homo sapiens	6-11
23525258-2	2013	Heme oxygenase (HO)-1 and its by-products, iron and carbon monoxide (CO), play crucial roles in hepatic fibrosis.	Iron	43-47	heme oxygenase 1	Rattus norvegicus	0-21
23487432-5	2013	Characterization of the COPT2 expression pattern indicates a synergic response to copper and iron limitation in roots.	Iron	93-97	copper transporter 2	Arabidopsis thaliana	24-29
33486678-0	2021	Growth differentiation factor-15 and lactoferrin immuno-expression in breast cancer: relationship with body iron-status and survival outcome.	Iron	108-112	growth differentiation factor 15	Homo sapiens	0-32
23487432-8	2013	First, COPT2 participates in the attenuation of copper deficiency responses driven by iron limitation, possibly to minimize further iron consumption.	Iron	86-90	copper transporter 2	Arabidopsis thaliana	7-12
23487432-8	2013	First, COPT2 participates in the attenuation of copper deficiency responses driven by iron limitation, possibly to minimize further iron consumption.	Iron	132-136	copper transporter 2	Arabidopsis thaliana	7-12
33486678-1	2021	We aimed to evaluate the expression of growth differentiation factor-15 (GDF-15) and lactoferrin (Lf) in tumor and their relationship with the body iron-status and overall survival (OS) outcome of patients with breast cancer.	Iron	148-152	growth differentiation factor 15	Homo sapiens	39-71
23798277-1	2013	Methemoglobin is formed upon iron oxidation of the heme molecule from ferrous (Fe2+) to its ferric (Fe3+) state.	Iron	29-33	hemoglobin subunit gamma 2	Homo sapiens	0-13
33486678-1	2021	We aimed to evaluate the expression of growth differentiation factor-15 (GDF-15) and lactoferrin (Lf) in tumor and their relationship with the body iron-status and overall survival (OS) outcome of patients with breast cancer.	Iron	148-152	growth differentiation factor 15	Homo sapiens	73-79
33486678-8	2021	The serum iron level of patients with GDF-15 (+)/Lf(-) expression was higher than that of patients with other expression patterns (18.2 +- 5.4 vs. 15.5 +- 5.0 mumol/L, P = 0.038), but was not associated with OS.	Iron	10-14	growth differentiation factor 15	Homo sapiens	38-44
33486678-12	2021	The combined immuno-expression pattern of GDF-15 and Lf was significant associated with high serum iron level.	Iron	99-103	growth differentiation factor 15	Homo sapiens	42-48
33710119-10	2021	miR-210 and miR-122 collectively play a role in maintaining the iron balance.	Iron	64-68	microRNA 122	Homo sapiens	12-19
23596212-2	2013	In the cytosolic iron-sulfur protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-sulfur cluster proteins.	Iron	17-21	NADPH dependent diflavin oxidoreductase 1	Homo sapiens	71-122
23596212-2	2013	In the cytosolic iron-sulfur protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-sulfur cluster proteins.	Iron	17-21	NADPH dependent diflavin oxidoreductase 1	Homo sapiens	124-129
23596212-2	2013	In the cytosolic iron-sulfur protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-sulfur cluster proteins.	Iron	240-244	NADPH dependent diflavin oxidoreductase 1	Homo sapiens	71-122
23596212-2	2013	In the cytosolic iron-sulfur protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-sulfur cluster proteins.	Iron	240-244	NADPH dependent diflavin oxidoreductase 1	Homo sapiens	124-129
33687417-4	2021	Intracellular iron was enriched with an iron-containing MOF, whose endocytosis can be further facilitated by transferrin decorated on the lipid layer, which provides a prerequisite for the occurrence of ferroptosis and pyroptosis.	Iron	14-18	transferrin	Mus musculus	109-120
23333676-0	2013	Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation.	Iron	115-119	transferrin receptor 2	Mus musculus	41-63
23454841-0	2013	Ab initio calculation of spin-dependent electron-phonon coupling in iron and cobalt.	Iron	68-72	spindlin 1	Homo sapiens	25-29
23454841-1	2013	The spin-dependent coupling between electrons and phonons in ferromagnetic Fe and Co is calculated from first principles in a collinear-spin formalism.	Iron	75-77	spindlin 1	Homo sapiens	4-8
23454841-1	2013	The spin-dependent coupling between electrons and phonons in ferromagnetic Fe and Co is calculated from first principles in a collinear-spin formalism.	Iron	75-77	spindlin 1	Homo sapiens	136-140
33687417-4	2021	Intracellular iron was enriched with an iron-containing MOF, whose endocytosis can be further facilitated by transferrin decorated on the lipid layer, which provides a prerequisite for the occurrence of ferroptosis and pyroptosis.	Iron	40-44	transferrin	Mus musculus	109-120
33493903-1	2021	Association of both iron/hepcidin and apolipoprotein E (ApoE) with development of Alzheimer disease (AD) and atherosclerosis led us to hypothesize that ApoE might be required for body iron homeostasis.	Iron	184-188	hepcidin antimicrobial peptide	Mus musculus	25-33
23524968-2	2013	Both disorders are characterized by low levels of hepcidin (HAMP), the hormone that regulates iron absorption.	Iron	94-98	hepcidin antimicrobial peptide	Mus musculus	50-58
23524968-2	2013	Both disorders are characterized by low levels of hepcidin (HAMP), the hormone that regulates iron absorption.	Iron	94-98	hepcidin antimicrobial peptide	Mus musculus	60-64
23524968-7	2013	ASO treatment in mice affected by hemochromatosis (Hfe(-/-)) significantly decreased serum iron, transferrin saturation and liver iron accumulation.	Iron	91-95	homeostatic iron regulator	Mus musculus	51-54
23524968-7	2013	ASO treatment in mice affected by hemochromatosis (Hfe(-/-)) significantly decreased serum iron, transferrin saturation and liver iron accumulation.	Iron	130-134	homeostatic iron regulator	Mus musculus	51-54
33493903-3	2021	Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1.	Iron	52-56	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	148-152
33737539-7	2021	At 14q32, miR-432-5p and miR-127-3p were ~ 100-fold downregulated whereas miR-138-5p was 16-fold downregulated at 3p21 in chronic iron-exposed FTSECs.	Iron	130-134	microRNA 432	Homo sapiens	10-17
23344952-3	2013	Here, using small-angle x-ray scattering and x-ray crystallography, we describe the solution structure of the oligomers formed during the iron-dependent assembly of yeast (Yfh1) and Escherichia coli (CyaY) frataxin.	Iron	138-142	ferroxidase	Saccharomyces cerevisiae S288C	172-176
23344952-4	2013	At an iron-to-protein ratio of 2, the initially monomeric Yfh1 is converted to a trimeric form in solution.	Iron	6-10	ferroxidase	Saccharomyces cerevisiae S288C	58-62
23344952-7	2013	For the ferroxidation-deficient D79A/D82A variant of Yfh1, iron-dependent oligomerization may still take place, although &gt;50% of the protein is found in the monomeric state at the highest iron-to-protein ratio used.	Iron	59-63	ferroxidase	Saccharomyces cerevisiae S288C	53-57
33737539-11	2021	Interestingly, overexpression of miR-432-5p diminished cell numbers induced by long-term iron exposure in FTSECs.	Iron	89-93	microRNA 432	Homo sapiens	33-40
23344952-7	2013	For the ferroxidation-deficient D79A/D82A variant of Yfh1, iron-dependent oligomerization may still take place, although &gt;50% of the protein is found in the monomeric state at the highest iron-to-protein ratio used.	Iron	191-195	ferroxidase	Saccharomyces cerevisiae S288C	53-57
33836599-2	2021	We carried out chronological and archaeomagnetic studies at the Angkor-era iron-smelting site of Tonle Bak in Cambodia in Southeast Asia, an area with no data available to date.	Iron	75-79	BCL2 antagonist/killer 1	Homo sapiens	103-106
23503321-2	2013	The interfacial initiation system is comprised of an enzymatic reaction between glucose and glucose oxidase (GOx) to generate hydrogen peroxide, which, in the presence of iron (Fe2+), generates hydroxyl radicals that initiate polymerization.	Iron	171-175	hydroxyacid oxidase 1	Homo sapiens	92-107
33712594-5	2021	Knockdown of ferritin heavy chain (FTH1) in iron replete progenitors induces microtubule collapse and erythropoietic blockade; conversely, enforced ferritin expression rescues erythroid differentiation under conditions of iron restriction.	Iron	44-48	ferritin heavy polypeptide 1	Mus musculus	13-33
23503321-2	2013	The interfacial initiation system is comprised of an enzymatic reaction between glucose and glucose oxidase (GOx) to generate hydrogen peroxide, which, in the presence of iron (Fe2+), generates hydroxyl radicals that initiate polymerization.	Iron	171-175	hydroxyacid oxidase 1	Homo sapiens	109-112
23503321-7	2013	When the locations of glucose and GOx are interchanged, the average thickness of the shell was 15 or 100 mum for bulk iron concentrations of 45 and 12.5 mM, respectively.	Iron	118-122	hydroxyacid oxidase 1	Homo sapiens	34-37
23503321-9	2013	Specifically, for a bulk iron concentration of 45 mM, the thickness of the interpenetrating layer averaged 12 mum when GOx was initially within the core, whereas no interpenetrating layer was observed when glucose was incorporated in the core.	Iron	25-29	hydroxyacid oxidase 1	Homo sapiens	119-122
33712594-5	2021	Knockdown of ferritin heavy chain (FTH1) in iron replete progenitors induces microtubule collapse and erythropoietic blockade; conversely, enforced ferritin expression rescues erythroid differentiation under conditions of iron restriction.	Iron	44-48	ferritin heavy polypeptide 1	Mus musculus	35-39
22983584-1	2013	In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of iron into the blood stream from duodenal enterocytes and macrophages.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	57-65
33712594-5	2021	Knockdown of ferritin heavy chain (FTH1) in iron replete progenitors induces microtubule collapse and erythropoietic blockade; conversely, enforced ferritin expression rescues erythroid differentiation under conditions of iron restriction.	Iron	222-226	ferritin heavy polypeptide 1	Mus musculus	13-33
22983584-1	2013	In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of iron into the blood stream from duodenal enterocytes and macrophages.	Iron	159-163	hepcidin antimicrobial peptide	Mus musculus	57-65
33712594-5	2021	Knockdown of ferritin heavy chain (FTH1) in iron replete progenitors induces microtubule collapse and erythropoietic blockade; conversely, enforced ferritin expression rescues erythroid differentiation under conditions of iron restriction.	Iron	222-226	ferritin heavy polypeptide 1	Mus musculus	35-39
33543738-4	2021	These MOFs along with NEU-1c [= Zn(BPDI)(Py)2] and NEU-2 [= Fe(BPDI)(Py)2] display an electron-deficient pore surface due to predesigned pi-electron-deficient ligands.	Iron	60-62	neuraminidase 2	Homo sapiens	51-56
23895519-3	2013	Investigations on biologic functions of transferrin (Tf) other than iron transport showed that Tf has a profound cytoprotective (anti-apoptotic) effect on lympho-hematopoietic cells and the thymus, and interferes with stress-induced signals.	Iron	68-72	transferrin	Mus musculus	95-97
23012398-0	2013	Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.	Iron	0-4	cytochrome b reductase 1	Homo sapiens	90-96
23166001-0	2013	PANK2 and C19orf12 mutations are common causes of neurodegeneration with brain iron accumulation.	Iron	79-83	chromosome 19 open reading frame 12	Homo sapiens	10-18
33569838-5	2021	Density functional theory calculations suggest that gamma-NiOOH in situ generated from the electrooxidation of NF would induce charge accumulation on the Fe sites of gamma-FeOOH NAs, leading to enhanced OER intermediates adsorption for water splitting.	Iron	154-156	neurofascin	Homo sapiens	111-113
23182811-6	2013	A series of one-way sensitivity analyses show that the ICER is most sensitive to the probability of achieving haemoglobin (Hb) targets using supplemental iron with a consequential decrease in the standard ESA doses and the relative increased risk in all-cause mortality associated with low Hb levels (Hb &lt; 9.0 g/dL).	Iron	154-158	cAMP responsive element modulator	Homo sapiens	55-59
33706250-10	2021	There was also a significant association between lower cortical R2*, suggestive of reduced myelin or iron, and higher CSF NfL in the frontal lobe and the parieto-occipital cortices.	Iron	101-105	neurofilament light chain	Homo sapiens	122-125
23168578-5	2013	RESULTS: Despite a significantly poorer status at 6 wk, iron-supplemented infants had significantly higher hemoglobin level (Hb): 12.2 (SD = 0.8) g/dl and CHr: 28.3 (SD = 1.4) pg at 6 mo, as compared with nonsupplemented infants, Hb: 11.7 (SD = 1.0) g/dl, P = 0.02 and CHr: 26.5 (SD = 2.5) pg, P &lt; 0.001.	Iron	56-60	chromate resistance; sulfate transport	Homo sapiens	155-158
23440025-1	2012	Nitrogenase enzymes have evolved complex iron-sulfur (Fe-S) containing cofactors that most commonly contain molybdenum (MoFe, Nif) as a heterometal but also exist as vanadium (VFe, Vnf) and heterometal-independent (Fe-only, Anf) forms.	Iron	54-58	S100 calcium binding protein A9	Homo sapiens	126-129
23440025-1	2012	Nitrogenase enzymes have evolved complex iron-sulfur (Fe-S) containing cofactors that most commonly contain molybdenum (MoFe, Nif) as a heterometal but also exist as vanadium (VFe, Vnf) and heterometal-independent (Fe-only, Anf) forms.	Iron	54-56	S100 calcium binding protein A9	Homo sapiens	126-129
31919087-4	2021	Here, using murine models, we study the involvement of hepcidin, the key regulator of iron metabolism and an important player in the development of anemia of inflammation.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	55-63
32260814-1	2013	An innovative MOS-type field effect transistor was developed for the electrical detection of ferric ions.	Iron	93-104	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	14-17
33035687-2	2021	Fibroblast growth factor 23 (FGF23), a hormone involved in phosphate, vitamin D and iron homeostasis, is linked to LVH and HF.	Iron	84-88	fibroblast growth factor 23	Homo sapiens	0-27
23169885-1	2013	PURPOSE: Hemochromatosis is a disorder of iron overload arising mostly from mutations in HFE.	Iron	42-46	homeostatic iron regulator	Mus musculus	89-92
23169885-2	2013	HFE is expressed in retinal pigment epithelium (RPE), and Hfe(-/-) mice develop age-related iron accumulation and retinal degeneration associated with RPE hyperproliferation.	Iron	92-96	homeostatic iron regulator	Mus musculus	58-61
33035687-2	2021	Fibroblast growth factor 23 (FGF23), a hormone involved in phosphate, vitamin D and iron homeostasis, is linked to LVH and HF.	Iron	84-88	fibroblast growth factor 23	Homo sapiens	29-34
23135277-7	2013	The responsiveness of IRP2 to low iron is specifically enhanced in the duodena of the heterozygotes and is accompanied by increased expression of the divalent metal transporter-1.	Iron	34-38	iron responsive element binding protein 2	Mus musculus	22-26
33568304-3	2021	Previously, we have demonstrated the relationship between the PAP/SAL1 retrograde signaling pathway, the activity of Strategy I Fe uptake genes (FIT, FRO2, IRT1), and ethylene signaling.	Iron	128-130	iron-regulated transporter 1	Arabidopsis thaliana	156-160
23504535-0	2013	Spin state switching in iron coordination compounds.	Iron	24-28	spindlin 1	Homo sapiens	0-4
33639162-8	2021	And the highly expressed genes in HBB2-targeted rabbits were enriched in lipid and iron metabolism, innate immunity and hematopoietic processes.	Iron	83-87	hemoglobin subunit beta-1/2	Oryctolagus cuniculus	34-38
23022490-9	2013	Correlation of the reaction rates of CcP and 12 distal pocket mutants with H(2)O(2) and HCN suggests that both reactions require ionization of the reactants within the distal heme pocket allowing the anion to bind the heme iron.	Iron	223-227	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	37-40
33600478-0	2021	Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera.	Iron	21-25	transferrin	Apis mellifera	0-11
22921471-1	2013	Ferroportin (FPN), the sole characterized iron exporter, is mainly controlled by the peptide hormone hepcidin in response to iron, erythroid factors, hypoxia, and inflammation.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	101-109
22921471-1	2013	Ferroportin (FPN), the sole characterized iron exporter, is mainly controlled by the peptide hormone hepcidin in response to iron, erythroid factors, hypoxia, and inflammation.	Iron	125-129	hepcidin antimicrobial peptide	Mus musculus	101-109
22921471-8	2013	Thus, hypoxia, by directly controlling hepcidin and its target FPN, orchestrates a complex regulatory network aimed at ensuring rapid iron recovery from the periphery and efficient iron utilization in the erythroid compartment.	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	39-47
22921471-8	2013	Thus, hypoxia, by directly controlling hepcidin and its target FPN, orchestrates a complex regulatory network aimed at ensuring rapid iron recovery from the periphery and efficient iron utilization in the erythroid compartment.	Iron	181-185	hepcidin antimicrobial peptide	Mus musculus	39-47
33600478-6	2021	The expression of transferrin, an iron binding and transporting protein that is one of the key players of iron homeostasis, in response to N. ceranae infection was analysed.	Iron	34-38	transferrin	Apis mellifera	18-29
33600478-6	2021	The expression of transferrin, an iron binding and transporting protein that is one of the key players of iron homeostasis, in response to N. ceranae infection was analysed.	Iron	106-110	transferrin	Apis mellifera	18-29
23291753-5	2013	The oxygen-responsive regulator FnrL and a predicted iron-sensing regulator were perhaps also involved in the transcriptome response to reactive nitrogen species.	Iron	53-57	Crp/Fnr family transcriptional regulator	Rhodobacter sphaeroides 2.4.1	32-36
33600478-7	2021	Furthermore, the functional roles of transferrin in iron homeostasis and honey bee host immunity were characterized using an RNA interference (RNAi)-based method.	Iron	52-56	transferrin	Apis mellifera	37-48
33600478-10	2021	The intriguing multifunctionality of transferrin illustrated in this study is a significant contribution to the existing body of literature concerning iron homeostasis in insects.	Iron	151-155	transferrin	Apis mellifera	37-48
33600478-11	2021	The uncovered functional role of transferrin on iron homeostasis, pathogen growth and honey bee"s ability to mount immune responses may hold the key for the development of novel strategies to treat or prevent diseases in honey bees.	Iron	48-52	transferrin	Apis mellifera	33-44
33597025-4	2021	We identified a subset of microglia with increased expression of the iron storage protein ferritin light chain (FTL), together with increased Iba1 expression, decreased TMEM119 and P2RY12 expression.	Iron	69-73	ferritin light chain	Homo sapiens	90-110
24418880-10	2013	Our results indicate that IL-6 and iron may affect the signaling pathways governing hepcidin expression.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	84-92
24418880-12	2013	In addition, hepcidin may play local roles in controlling iron availability and interfering with inflammation in adipose tissue.	Iron	58-62	hepcidin antimicrobial peptide	Mus musculus	13-21
23071099-4	2013	The deletion of ASC1 reduces iron uptake and causes nitrosative stress, both known indicators for hypoxia, which manifests in a shift of energy metabolism from respiration to fermentation in the Deltaasc1 strain.	Iron	29-33	guanine nucleotide-binding protein subunit beta	Saccharomyces cerevisiae S288C	16-20
33597025-4	2021	We identified a subset of microglia with increased expression of the iron storage protein ferritin light chain (FTL), together with increased Iba1 expression, decreased TMEM119 and P2RY12 expression.	Iron	69-73	ferritin light chain	Homo sapiens	112-115
33609526-8	2021	These findings reveal a conserved function of FLCN in iron metabolism and may help to elucidate the mechanisms driving BHD syndrome.	Iron	54-58	Birt-Hogg-Dube	Drosophila melanogaster	46-50
33592127-12	2021	In vitro, differentiated osteocyte-like cells exposed to an iron chelator to simulate iron depletion/hypoxia increased FGF23; repletion with holo-transferrin completely suppressed FGF23 and normalized Tfrc1.	Iron	60-64	fibroblast growth factor 23	Mus musculus	119-124
33592127-12	2021	In vitro, differentiated osteocyte-like cells exposed to an iron chelator to simulate iron depletion/hypoxia increased FGF23; repletion with holo-transferrin completely suppressed FGF23 and normalized Tfrc1.	Iron	60-64	fibroblast growth factor 23	Mus musculus	180-185
33592127-13	2021	Collectively, these results support that resolving anemia using a HIF-PHI during CKD was associated with lower BUN and reduced FGF23, potentially through direct restoration of iron utilization, thus providing modifiable outcomes beyond improving anemia for this patient population.	Iron	176-180	fibroblast growth factor 23	Homo sapiens	127-132
33180328-1	2021	beta-thalassemias result from mutations in beta-globin, causing ineffective erythropoiesis and secondary iron overload due to inappropriately low levels of the iron regulatory hormone hepcidin.	Iron	105-109	hemoglobin beta chain complex	Mus musculus	43-54
33180328-1	2021	beta-thalassemias result from mutations in beta-globin, causing ineffective erythropoiesis and secondary iron overload due to inappropriately low levels of the iron regulatory hormone hepcidin.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	184-192
33180328-1	2021	beta-thalassemias result from mutations in beta-globin, causing ineffective erythropoiesis and secondary iron overload due to inappropriately low levels of the iron regulatory hormone hepcidin.	Iron	160-164	hemoglobin beta chain complex	Mus musculus	43-54
33180328-1	2021	beta-thalassemias result from mutations in beta-globin, causing ineffective erythropoiesis and secondary iron overload due to inappropriately low levels of the iron regulatory hormone hepcidin.	Iron	160-164	hepcidin antimicrobial peptide	Mus musculus	184-192
33180328-2	2021	Mutations in TFR2 lead to hereditary hemochromatosis (HH) as a result of inappropriately increased iron uptake from the diet, also due to improperly regulated hepcidin.	Iron	99-103	transferrin receptor 2	Mus musculus	13-17
33180328-4	2021	TMPRSS6, a membrane serine protease expressed selectively in the liver, participates in regulating hepcidin production in response to iron stores by cleaving hemojuvelin (HJV).	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	99-107
33180328-4	2021	TMPRSS6, a membrane serine protease expressed selectively in the liver, participates in regulating hepcidin production in response to iron stores by cleaving hemojuvelin (HJV).	Iron	134-138	hemojuvelin BMP co-receptor	Mus musculus	158-169
33180328-6	2021	Here, we demonstrate that Tmprss6 siRNA treatment of double mutant Tfr2Y245X/Y245X HH Hbbth3/+ thalassemic mice induces hepcidin and diminishes tissue and serum iron levels.	Iron	161-165	transferrin receptor 2	Mus musculus	67-71
33180328-8	2021	Furthermore, we also show that treatment of Tfr2Y245X/Y245X HH mice leads to increased hepcidin expression and reduced total body iron burden.	Iron	130-134	transferrin receptor 2	Mus musculus	44-48
33180328-9	2021	These data indicate that siRNA suppression of Tmprss6, in conjunction with the targeting of TFR2, may be superior to inhibiting Tmprss6 alone in the treatment of the anemia and secondary iron loading in beta-thalassemia intermedia and may be useful as a method of suppressing the primary iron overload in TFR2-related (type 3) hereditary hemochromatosis.	Iron	288-292	transferrin receptor 2	Mus musculus	92-96
33022879-0	2021	Spin-controlled binding of carbon dioxide by an iron center.	Iron	48-52	spindlin 1	Homo sapiens	0-4
32193252-2	2021	Activation of toll-like receptors (TLRs), the key sensors of the innate immune system, induces hypoferremia mainly through the rise of the iron hormone hepcidin.	Iron	139-143	hepcidin antimicrobial peptide	Mus musculus	152-160
33336851-0	2021	Iron accumulation regulates osteoblast apoptosis through lncRNA XIST/miR-758-3p/caspase 3 axis leading to osteoporosis.	Iron	0-4	inactive X specific transcripts	Mus musculus	64-68
33336851-0	2021	Iron accumulation regulates osteoblast apoptosis through lncRNA XIST/miR-758-3p/caspase 3 axis leading to osteoporosis.	Iron	0-4	caspase 3	Mus musculus	80-89
33449164-2	2021	We questioned that whether LCN2 might also associate exogenous iron chelator as does in inherent way and the association may influence their respective function.	Iron	63-67	lipocalin 2	Homo sapiens	27-31
33449164-7	2021	Undergoing epithelium-mesenchymal transition (EMT) is a crucial step for cancer metastasis, LCN2 and DpdtC had opposite effects on EMT markers, the binding of DpdtC to LCN2 significantly weakened the regulation of it (or its iron chelate) on EMT markers.	Iron	225-229	lipocalin 2	Homo sapiens	168-172
33449164-8	2021	To insight into the interaction between LCN2 and DpdtC-iron, fluorescence titration and molecular docking were performed to obtain the association constant (~ 104 M-1) and thermodynamic parameters (DeltaG = - 26.10 kJ/mol).	Iron	55-59	lipocalin 2	Homo sapiens	40-44
33325123-8	2021	CONCLUSIONS: We showed that functional failure of beta cells due to iron accumulation was rescued by 1,25(OH)2 D3 , and iron overload significantly reduced VDR levels in beta cells.	Iron	120-124	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	156-159
33278722-4	2021	Typically, the addition of FeCl3 and Fe2(SO4)3 enhanced Fe mobility in sediment and overlying water, promoting the formation of Fe-humin acid and ferrous sulfides (FeS and FeS2).	Iron	164-167	general transcription factor IIE subunit 1	Homo sapiens	27-29
33278722-4	2021	Typically, the addition of FeCl3 and Fe2(SO4)3 enhanced Fe mobility in sediment and overlying water, promoting the formation of Fe-humin acid and ferrous sulfides (FeS and FeS2).	Iron	164-167	general transcription factor IIE subunit 1	Homo sapiens	37-39
33510144-4	2021	Mechanistically, NUPR1-mediated LCN2 expression blocks ferroptotic cell death through diminishing iron accumulation and subsequent oxidative damage.	Iron	98-102	nuclear protein transcription regulator 1	Mus musculus	17-22
33510144-7	2021	These findings suggest a link between NUPR1-regulated iron metabolism and ferroptosis susceptibility.	Iron	54-58	nuclear protein transcription regulator 1	Mus musculus	38-43
33475175-2	2021	FECH catalyzes the chelation of iron into protoporphyrin IX to form heme.	Iron	32-36	ferrochelatase	Homo sapiens	0-4
33551834-2	2020	Here, we review pathophysiological aspects of PKD, focusing on the interplay between pyruvate kinase (PK)-activity and reticulocyte maturation in the light of ferroptosis, an iron-dependent process of regulated cell death, and in particular its key player glutathione peroxidase 4 (GPX4).	Iron	175-179	protein kinase D1	Homo sapiens	46-49
33510871-4	2021	Based on the in-depth analysis of the binding mode, strong electron-withdrawing group on the C4 position of the imidazole ring was introduced to reduce the charge density of the nitrogen, which is beneficial in reducing the coordination bond between the imidazole nitrogen and heme iron in CYP11B1, as well as in reducing the adrenocortical suppression.	Iron	282-286	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	290-297
33402348-7	2021	Rather, expression of SBW25 genes encoding a porin, a transporter, and a monooxygenase was significantly upregulated in response to Fe deprivation.	Iron	132-134	PFLU_RS11315	Pseudomonas fluorescens SBW25	45-50
33488942-0	2021	The Effects of Dandelion Polysaccharides on Iron Metabolism by Regulating Hepcidin via JAK/STAT Signaling Pathway.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	74-82
33488942-4	2021	Hepcidin is a central regulator in iron metabolism.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	0-8
32574785-13	2021	DMT1(-)IRE knockdown attenuated iron accumulation but did not influence Ca2+ influx.	Iron	32-36	RoBo-1	Rattus norvegicus	0-4
32574785-14	2021	This study suggests that DMT1(-)IRE-mediated iron accumulation is likely to be the downstream event following NMDA receptor activation and Ca2+ influx, contributing to remifentanil-induced hyperalgesia.	Iron	45-49	RoBo-1	Rattus norvegicus	25-29
33160991-9	2021	SIGNIFICANCE: PM2.5 inhalation could exacerbate the formation and development of atherosclerosis in ApoE-/- mice, the potential mechanisms may be partly associated with iron overload via the hepcidin-FPN axis, as well as iron-triggered systemic inflammation and hyperlipidemia.	Iron	169-173	hepcidin antimicrobial peptide	Mus musculus	191-199
33160991-9	2021	SIGNIFICANCE: PM2.5 inhalation could exacerbate the formation and development of atherosclerosis in ApoE-/- mice, the potential mechanisms may be partly associated with iron overload via the hepcidin-FPN axis, as well as iron-triggered systemic inflammation and hyperlipidemia.	Iron	221-225	hepcidin antimicrobial peptide	Mus musculus	191-199
32997872-2	2021	Physiologically, CREBH is intrinsically linked to nutritional homeostasis via its regulation on fatty acid beta-oxidation, lipid droplet process, very low-density lipoprotein metabolism, gluconeogenesis, and iron metabolism.	Iron	208-212	cAMP responsive element binding protein 3 like 3	Homo sapiens	17-22
33367898-4	2021	In Arabidopsis, the CIPK23 kinase has emerged as a major hub driving root responses to diverse environmental stresses including drought, salinity and nutrient imbalances such as potassium, nitrate and iron deficiencies as well as ammonium, magnesium and non-iron metals toxicities.	Iron	98-102	CBL-interacting protein kinase 23	Arabidopsis thaliana	20-26
33268027-4	2020	Iron-dependent lysosomal membrane permeability triggers the release of CTSB from the lysosome to nucleus during ferroptosis.	Iron	0-4	cathepsin B	Homo sapiens	71-75
33334885-8	2021	The profile of site-specific PAT1 expression in the mouse intestine coincided with those of NA and iron contents, which were highest in the proximal jejunum.	Iron	99-103	solute carrier family 36 (proton/amino acid symporter), member 1	Mus musculus	29-33
33011567-9	2020	For a pre-oxidation with Mn(VII), ClO2 and Fe(VI), similar correlations between the EDC abatement and the chlorine demand or the adsorbable organic halide (AOX) formation were obtained.	Iron	43-45	acyl-CoA oxidase 1	Homo sapiens	156-159
33344239-6	2020	In parallel, iron application inhibited the activation, expansion and survival of cytotoxic CD8+ T cells and of CD4+ T helper cells type 1 and significantly reduced the efficacy of the investigated anti-cancer treatments.	Iron	13-17	CD4 antigen	Mus musculus	112-115
33268384-10	2021	Vma2Delta cells from previously studied strain BY4741 exhibited iron-associated properties more consistent with prior studies, suggesting subtle strain differences.	Iron	64-68	H(+)-transporting V1 sector ATPase subunit B	Saccharomyces cerevisiae S288C	0-4
32980916-10	2020	Indeed, we could demonstrate Cti6 recruitment to promoters of genes, such as RNR3 and SMF3, containing iron-responsive elements (IRE).	Iron	103-107	RNA, ribosomal 45S cluster 3	Homo sapiens	77-81
33080340-0	2020	Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.	Iron	5-9	thyroid hormone receptor interactor 12	Mus musculus	27-33
33221470-2	2020	HHCS is caused by mutations in the iron-responsive element of the FTL gene.	Iron	35-39	ferritin light chain	Homo sapiens	66-69
32951052-0	2020	Intact & C-terminal FGF-23 Assays- Do Kidney Function, Inflammation, & Iron Status Influence Relationships with Outcomes?	Iron	71-75	fibroblast growth factor 23	Homo sapiens	20-26
23797049-4	2013	The aim of the study was to assess GDF15 levels with relation to iron parameters in 62 stable kidney allograft recipients maintained on triple immunosuppressive therapy.	Iron	65-69	growth differentiation factor 15	Homo sapiens	35-40
33405355-0	2020	AtHAP5A regulates iron translocation in iron-deficient Arabidopsis thaliana.	Iron	18-22	nuclear factor Y, subunit C1	Arabidopsis thaliana	0-7
23262393-5	2013	Moreover, DFO intranasal administration also decreases Fe-induced the activities of cyclin-dependent kinase 5 (CDK5) and glycogen synthase kinase 3beta (GSK3beta), which in turn suppressing tau phosphorylation.	Iron	55-57	cyclin-dependent kinase 5	Mus musculus	84-109
23262393-5	2013	Moreover, DFO intranasal administration also decreases Fe-induced the activities of cyclin-dependent kinase 5 (CDK5) and glycogen synthase kinase 3beta (GSK3beta), which in turn suppressing tau phosphorylation.	Iron	55-57	cyclin-dependent kinase 5	Mus musculus	111-115
23262393-6	2013	Cumulatively, our data show that intranasal DFO treatment exerts its suppressive effects on iron induced tau phosphorylation via CDK5 and GSK3beta pathways.	Iron	92-96	cyclin-dependent kinase 5	Mus musculus	129-133
33405355-0	2020	AtHAP5A regulates iron translocation in iron-deficient Arabidopsis thaliana.	Iron	40-44	nuclear factor Y, subunit C1	Arabidopsis thaliana	0-7
33405355-7	2020	Moreover, overexpression of NAS1 could rescue the chlorosis phenotype of hap5a in Fe deficient conditions.	Iron	82-84	nuclear factor Y, subunit C1	Arabidopsis thaliana	73-78
33405355-8	2020	In summary, a novel pathway was elucidated, showing that NAS1-dependent translocation of Fe from the root to the shoot is controlled by HAP5A in Fe-deficient Arabidopsis thaliana.	Iron	89-91	nuclear factor Y, subunit C1	Arabidopsis thaliana	136-141
23404745-2	2013	The aim of this study was to evaluate the effect of tamibarotene, a selective retinoic acid receptor alpha/beta agonist, on hepatic iron metabolism, based on our previous findings that retinoids suppress hepatic iron accumulation by increasing hepatic iron efflux through the regulation of hemojuvelin and ferroportin expression.	Iron	132-136	retinoic acid receptor, alpha	Mus musculus	78-106
33405355-8	2020	In summary, a novel pathway was elucidated, showing that NAS1-dependent translocation of Fe from the root to the shoot is controlled by HAP5A in Fe-deficient Arabidopsis thaliana.	Iron	145-147	nuclear factor Y, subunit C1	Arabidopsis thaliana	136-141
32763423-7	2020	We applied our new sorting strategy to demonstrate that CD71, which is the transferrin receptor mediating the uptake of transferrin-bound iron, is upregulated in beta-cells during early postnatal weeks.	Iron	138-142	transferrin	Mus musculus	75-86
23781295-2	2013	In this pathway, Hb tightly binds to Hp leading to CD163-mediated uptake of the complex in macrophages followed by lysosomal Hp-Hb breakdown and HO-1-catalyzed conversion of heme into the metabolites carbon monoxide (CO), biliverdin, and iron.	Iron	238-242	CD163 molecule	Homo sapiens	51-56
23555610-11	2013	In summary, the associations of circulating FGF-23 concentration with parameters of glucose metabolism, bone density and atherosclerosis are dependent on iron and obesity status-associated insulin resistance.	Iron	154-158	fibroblast growth factor 23	Homo sapiens	44-50
23437357-0	2013	N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.	Iron	126-130	N-myc downstream regulated 1	Homo sapiens	0-28
23437357-0	2013	N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.	Iron	126-130	N-myc downstream regulated 1	Homo sapiens	30-35
33017621-2	2020	However, frataxin, a mitochondrial protein mainly participating in iron homeostasis and oxidative stress, remains uncertain in the pathogenesis of ALD.	Iron	67-71	frataxin	Mus musculus	9-17
23437357-9	2013	Iron depletion also increased expression of the metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), and a known downstream repressed target of eIF3a, namely the cyclin-dependent kinase inhibitor, p27(kip1).	Iron	0-4	N-myc downstream regulated 1	Homo sapiens	71-104
23437357-9	2013	Iron depletion also increased expression of the metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), and a known downstream repressed target of eIF3a, namely the cyclin-dependent kinase inhibitor, p27(kip1).	Iron	0-4	N-myc downstream regulated 1	Homo sapiens	106-111
23390527-0	2013	Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant.	Iron	39-43	ankyrin 1, erythroid	Mus musculus	90-99
33017621-9	2020	Most importantly, frataxin deficiency enhanced ferroptosis driven by ethanol via evaluating the levels of lactate dehydrogenase, cell morphological changes, mitochondrial labile iron pool, and lipid peroxidation.	Iron	178-182	frataxin	Mus musculus	18-26
23390527-6	2013	The Ank1(Ity16/Ity16) mutation causes severe hemolytic anemia in uninfected mice resulting in splenomegaly, hyperbilirubinemia, jaundice, extramedullary erythropoiesis and iron overload in liver and kidneys.	Iron	172-176	ankyrin 1, erythroid	Mus musculus	4-8
32861780-10	2020	HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE.	Iron	37-41	homeostatic iron regulator	Mus musculus	0-3
23390527-7	2013	Ank1(Ity16/Ity16) mutant mice demonstrated low levels of hepcidin (Hamp) expression and significant increases in the expression of the growth differentiation factor 15 (Gdf15), erythropoietin (Epo) and heme oxygenase 1 (Hmox1) exacerbating extramedullary erythropoiesis, tissue iron deposition and splenomegaly.	Iron	278-282	ankyrin 1, erythroid	Mus musculus	0-4
23390527-10	2013	During infection, iron accumulated in the kidneys of Ank1(+/Ity16) mice where bacterial loads were high compared to littermate controls.	Iron	18-22	ankyrin 1, erythroid	Mus musculus	53-57
23390527-12	2013	This study illustrates that the regulation of Hamp and iron balance are crucial in the host response to Salmonella infection in Ank1 mutants.	Iron	55-59	ankyrin 1, erythroid	Mus musculus	128-132
32861780-10	2020	HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE.	Iron	37-41	homeostatic iron regulator	Mus musculus	106-109
32861780-10	2020	HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE.	Iron	81-85	homeostatic iron regulator	Mus musculus	0-3
32861780-10	2020	HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE.	Iron	81-85	homeostatic iron regulator	Mus musculus	106-109
32947011-8	2020	CONCLUSION: Our results show that IRP2-Iron-ROS axis is necessary for ART to induce ferroptosis in HSC and play an anti-fibrotic effect.	Iron	39-43	iron responsive element binding protein 2	Mus musculus	34-38
23349749-6	2013	Expression pattern of FOX1, FTR1 and ferredoxin was up-regulated by CO exposure in iron-deficient mediam.	Iron	83-87	uncharacterized protein	Chlamydomonas reinhardtii	28-32
32729980-4	2020	NQ-Cy@Fe&GOD can successfully monitor the intracellular release of IONPs and  OH-induced NQO1 enzyme in living cells and tumor-bearing mice, which makes a breakthrough in conquering the inherent unpredictable obstacles on spatio-temporally reporting chemodynamic therapy, so as to manipulate dose-dependent therapeutic process.	Iron	6-8	NAD(P)H dehydrogenase, quinone 1	Mus musculus	89-93
23853581-2	2013	Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 production regulates expression of iron chelators, heme and siderophore binding proteins and hepcidin in infected mice.	Iron	172-176	C-type lectin domain family 7, member a	Mus musculus	113-121
23853581-2	2013	Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 production regulates expression of iron chelators, heme and siderophore binding proteins and hepcidin in infected mice.	Iron	172-176	hepcidin antimicrobial peptide	Mus musculus	230-238
33124822-0	2020	Magnetism and Heterogeneous Catalysis: In Depth on the Quantum Spin-Exchange Interactions in Pt3M (M = V, Cr, Mn, Fe, Co, Ni, and Y)(111) Alloys.	Iron	114-116	spindlin 1	Homo sapiens	63-67
22835775-8	2012	Interestingly, GAPDH has been recently proposed to act as an alternative transferrin receptor for iron acquisition through internalization of the GAPDH-transferrin complex into the early endosomes.	Iron	98-102	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	15-20
22835775-8	2012	Interestingly, GAPDH has been recently proposed to act as an alternative transferrin receptor for iron acquisition through internalization of the GAPDH-transferrin complex into the early endosomes.	Iron	98-102	transferrin	Mus musculus	73-84
22835775-8	2012	Interestingly, GAPDH has been recently proposed to act as an alternative transferrin receptor for iron acquisition through internalization of the GAPDH-transferrin complex into the early endosomes.	Iron	98-102	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	146-151
22835775-8	2012	Interestingly, GAPDH has been recently proposed to act as an alternative transferrin receptor for iron acquisition through internalization of the GAPDH-transferrin complex into the early endosomes.	Iron	98-102	transferrin	Mus musculus	152-163
33119321-4	2020	The spin-split Kondo resonance provides quantitative information on the exchange field and on the spin polarization of the iron atom.	Iron	123-127	spindlin 1	Homo sapiens	4-8
33119321-4	2020	The spin-split Kondo resonance provides quantitative information on the exchange field and on the spin polarization of the iron atom.	Iron	123-127	spindlin 1	Homo sapiens	98-102
32584957-0	2020	Maternal Hepcidin Determines Embryo Iron Homeostasis.	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	9-17
32584957-9	2020	Higher doses of hepcidin agonist caused maternal iron restriction and anemia, lower placenta and embryo weight, embryo anemia, and increased embryo mortality.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	16-24
32584957-11	2020	Our studies demonstrate that suppression of maternal hepcidin during pregnancy is essential for maternal and embryo iron homeostasis and health.	Iron	116-120	hepcidin antimicrobial peptide	Mus musculus	53-61
32971353-5	2020	Cd2+ regulated the expression of genes associated with cellular Cu, Zn, and Fe homeostasis, DNA replication leading to cell cycle arrest and apoptosis, and glutathione metabolism.	Iron	76-78	si:ch211-132g1.1	Danio rerio	0-3
32567462-5	2020	This oxidative damage can also be linked to an unregulated influx of iron due to the upregulation of ion channel genes such as fepA in the lon mutant.	Iron	69-73	lon peptidase 1, mitochondrial	Mus musculus	139-142
32958690-3	2020	Hepcidin, an iron regulatory peptide hormone, is altered in subjects with COPD; however, the molecular role of hepcidin in COPD pathogenesis remains to be determined.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	0-8
33178287-2	2020	The higher incidence of ASXL1 and TET2 gene mutations in our iron overload (IO) MDS patients suggests that IO may be involved in the pathogenesis of MDS.	Iron	61-65	ASXL transcriptional regulator 1	Homo sapiens	24-29
33143294-0	2020	A Global Proteomic Approach Sheds New Light on Potential Iron-Sulfur Client Proteins of the Chloroplastic Maturation Factor NFU3.	Iron	57-61	NFU domain protein 3	Arabidopsis thaliana	124-128
32556142-8	2020	To overcome this issue, we postulated that some level of iron restriction (by targeting Tmprss6) would improve the splenomegaly while preserving the beneficial effects on RBC production mediated by EPO or Tfr2 deletion.	Iron	57-61	transferrin receptor 2	Mus musculus	205-209
33096672-6	2020	In particular, by using in vivo and in vitro models of fasting, we found that typical Nrf2-dependent genes, including those controlling iron (e.g., Ho-1) and glutathione (GSH) metabolism (e.g., Gcl, Gsr) are induced along with increased levels of the glutathione peroxidase 4 (Gpx4), a GSH-dependent antioxidant enzyme.	Iron	136-140	germ cell-less 2, spermatogenesis associated	Homo sapiens	194-197
33092142-5	2020	In neonates lacking HO1, functioning of renal molecular machinery responsible for iron reabsorption from the primary urine (megalin/cubilin complex) and its transfer to the blood (ferroportin) was either shifted in time or impaired, respectively.	Iron	82-86	cubilin (intrinsic factor-cobalamin receptor)	Mus musculus	132-139
33076949-0	2020	Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer"s disease.	Iron	82-86	sortilin related receptor 1	Homo sapiens	119-124
33086509-1	2020	We present a simple, low-cost, and environmental-friendly method for the fabrication of hybrid magnetorheological composites (hMCs) based on cotton fibers soaked with a mixture of silicone oil (SO), carbonyl iron (CI) microparticles, and iron oxide microfibers (muF).	Iron	38-42	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	126-130
33123307-5	2020	Furthermore, we revealed that iron overload-induced osteoblastic necrosis might be mediated via the RIPK1/RIPK3/MLKL necroptotic pathway.	Iron	30-34	receptor interacting serine/threonine kinase 3	Homo sapiens	106-111
32782144-9	2020	We suggest that low iron availability attenuates BCAA- and insulin-stimulated protein synthesis, possibly via activation of AMPK in myotubes.	Iron	20-24	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	124-128
33116751-5	2020	Iron overload was generated by 6 months of oral iron administration before CLP surgery- induced sepsis in TH mice and wild-type (WT) mice.	Iron	0-4	hyaluronan and proteoglycan link protein 1	Mus musculus	75-78
33116751-8	2020	With CLP in iron-overload mice, sepsis severity in TH mice was more severe than WT as determined by survival analysis, organ injury (kidney and liver), bacteremia, endotoxemia, gut leakage (FITC-dextran) and serum BG.	Iron	12-16	hyaluronan and proteoglycan link protein 1	Mus musculus	5-8
31848921-7	2020	Meanwhile, the increased divalent metal transporter 1 (DMT1) expression enhanced iron import and the decreased ferroportin 1 (Fpn1) expression reduced iron export in AlCl3-exposed groups.	Iron	81-85	RoBo-1	Rattus norvegicus	25-53
31848921-7	2020	Meanwhile, the increased divalent metal transporter 1 (DMT1) expression enhanced iron import and the decreased ferroportin 1 (Fpn1) expression reduced iron export in AlCl3-exposed groups.	Iron	81-85	RoBo-1	Rattus norvegicus	55-59
31848921-9	2020	The study also showed that iron regulatory factor iron regulatory protein 2 (IRP2) was decreased and hepcidin was increased in AlCl3-exposed groups.	Iron	27-31	iron responsive element binding protein 2	Rattus norvegicus	50-75
31848921-9	2020	The study also showed that iron regulatory factor iron regulatory protein 2 (IRP2) was decreased and hepcidin was increased in AlCl3-exposed groups.	Iron	27-31	iron responsive element binding protein 2	Rattus norvegicus	77-81
32470741-7	2020	Results show that Fe/Al BNPs and Al/Fe BNPs could reduce Cr6+ to Cr3+, and the removal efficiencies for Cr6+ were 1.47 g/g BNP and 0.07 g/g BNP, respectively.	Iron	18-20	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	104-107
32613509-2	2020	Especially when the mass ratio of Ag3PO4 was 20% of MIL-100(Fe) (APM-2), it displayed the best photocatalytic performance, for which the degradation rate of tetracycline (TC) in conventional environment was 6.8 times higher than that of bare MIL-100(Fe).	Iron	60-62	adipogenesis regulatory factor	Homo sapiens	65-70
32613509-2	2020	Especially when the mass ratio of Ag3PO4 was 20% of MIL-100(Fe) (APM-2), it displayed the best photocatalytic performance, for which the degradation rate of tetracycline (TC) in conventional environment was 6.8 times higher than that of bare MIL-100(Fe).	Iron	250-252	adipogenesis regulatory factor	Homo sapiens	65-70
32707154-2	2020	Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1).	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	0-8
32707154-2	2020	Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1).	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	0-8
32707154-3	2020	Studies have indicated that the astrocyte hepcidin could regulate brain iron intake at the blood-brain barrier and injection of hepcidin into brain attenuated iron deposition in the brain.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	42-50
32707154-4	2020	However, whether overexpression of hepcidin in astrocytes of APP/PS1 transgenic mice can alleviate AD symptoms by reducing iron deposition has not been evaluated.	Iron	123-127	hepcidin antimicrobial peptide	Mus musculus	35-43
33014705-8	2020	The best operation conditions consisted on using un-meshed vegetable AC, without acid pretreatment in an EF reactor loaded with 0.25 g of Fe, which allowed to reach full color removal of bright blue FCP model dye in 70 min.	Iron	138-140	FCP1	Homo sapiens	199-202
32793311-8	2020	Furthermore, erastin-induced breast cancer cell death was inhibited by an iron chelator, deferoxamine, which inhibited the increases of erastin-induced iron levels and inhibited the erastin-induced changes in the expression levels of the autophagy-related proteins beclin1, ATG5, ATG12, LC3B and P62.	Iron	74-78	beclin 1	Homo sapiens	265-272
32793311-8	2020	Furthermore, erastin-induced breast cancer cell death was inhibited by an iron chelator, deferoxamine, which inhibited the increases of erastin-induced iron levels and inhibited the erastin-induced changes in the expression levels of the autophagy-related proteins beclin1, ATG5, ATG12, LC3B and P62.	Iron	74-78	nucleoporin 62	Homo sapiens	296-299
32868463-2	2020	Blocking Fth synthesis in Sox10 or NG2-positive oligodendrocytes during the first or the third postnatal week significantly reduces oligodendrocyte iron storage and maturation.	Iron	148-152	ferritin heavy polypeptide 1	Mus musculus	9-12
32868463-2	2020	Blocking Fth synthesis in Sox10 or NG2-positive oligodendrocytes during the first or the third postnatal week significantly reduces oligodendrocyte iron storage and maturation.	Iron	148-152	chondroitin sulfate proteoglycan 4	Mus musculus	35-38
32868463-9	2020	These results indicate that Fth synthesis during the first three postnatal weeks is important for an appropriate oligodendrocyte development, and suggest that Fth iron storage in adult OPCs is also essential for an effective remyelination of the mouse brain.SIGNIFICANCE STATEMENT To define the importance of iron storage in oligodendrocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte lineage.	Iron	163-167	ferritin heavy polypeptide 1	Mus musculus	28-31
32868463-9	2020	These results indicate that Fth synthesis during the first three postnatal weeks is important for an appropriate oligodendrocyte development, and suggest that Fth iron storage in adult OPCs is also essential for an effective remyelination of the mouse brain.SIGNIFICANCE STATEMENT To define the importance of iron storage in oligodendrocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte lineage.	Iron	163-167	ferritin heavy polypeptide 1	Mus musculus	159-162
32868463-9	2020	These results indicate that Fth synthesis during the first three postnatal weeks is important for an appropriate oligodendrocyte development, and suggest that Fth iron storage in adult OPCs is also essential for an effective remyelination of the mouse brain.SIGNIFICANCE STATEMENT To define the importance of iron storage in oligodendrocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte lineage.	Iron	163-167	ferritin heavy polypeptide 1	Mus musculus	371-391
32868463-9	2020	These results indicate that Fth synthesis during the first three postnatal weeks is important for an appropriate oligodendrocyte development, and suggest that Fth iron storage in adult OPCs is also essential for an effective remyelination of the mouse brain.SIGNIFICANCE STATEMENT To define the importance of iron storage in oligodendrocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte lineage.	Iron	163-167	ferritin heavy polypeptide 1	Mus musculus	159-162
32868463-9	2020	These results indicate that Fth synthesis during the first three postnatal weeks is important for an appropriate oligodendrocyte development, and suggest that Fth iron storage in adult OPCs is also essential for an effective remyelination of the mouse brain.SIGNIFICANCE STATEMENT To define the importance of iron storage in oligodendrocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte lineage.	Iron	309-313	ferritin heavy polypeptide 1	Mus musculus	28-31
32868463-9	2020	These results indicate that Fth synthesis during the first three postnatal weeks is important for an appropriate oligodendrocyte development, and suggest that Fth iron storage in adult OPCs is also essential for an effective remyelination of the mouse brain.SIGNIFICANCE STATEMENT To define the importance of iron storage in oligodendrocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte lineage.	Iron	309-313	ferritin heavy polypeptide 1	Mus musculus	159-162
32868463-9	2020	These results indicate that Fth synthesis during the first three postnatal weeks is important for an appropriate oligodendrocyte development, and suggest that Fth iron storage in adult OPCs is also essential for an effective remyelination of the mouse brain.SIGNIFICANCE STATEMENT To define the importance of iron storage in oligodendrocyte function, we have deleted the ferritin heavy chain (Fth) specifically in the oligodendrocyte lineage.	Iron	309-313	ferritin heavy polypeptide 1	Mus musculus	159-162
32868463-14	2020	Therefore, Fth iron storage is essential for early oligodendrocyte development as well as for OPC maturation in the demyelinated adult brain.	Iron	15-19	ferritin heavy polypeptide 1	Mus musculus	11-14
32869045-2	2020	The native iron-containing heme substrate of NGB has been substituted with Zn(ii) protoporphyrin IX and the nitroxide has been attached via site-directed spin labeling to the Cys120 residue.	Iron	11-15	neuroglobin	Homo sapiens	45-48
32944219-4	2020	Results: Deletion of SDO1 resulted in a three-fold over-accumulation of intracellular iron.	Iron	86-90	guanine nucleotide exchange factor SDO1	Saccharomyces cerevisiae S288C	21-25
32944219-5	2020	Phenotypes associated with impaired iron-sulfur (ISC) assembly, up-regulation of the high affinity iron uptake pathway, and reduced activities of ISC containing enzymes aconitase and succinate dehydrogenase, were observed in sdo1  yeast.	Iron	36-40	guanine nucleotide exchange factor SDO1	Saccharomyces cerevisiae S288C	225-229
32944219-6	2020	In cells lacking Sdo1p, elevated levels of reactive oxygen species (ROS) and protein oxidation were reduced with iron chelation, using a cell impermeable iron chelator.	Iron	113-117	guanine nucleotide exchange factor SDO1	Saccharomyces cerevisiae S288C	17-22
32944219-6	2020	In cells lacking Sdo1p, elevated levels of reactive oxygen species (ROS) and protein oxidation were reduced with iron chelation, using a cell impermeable iron chelator.	Iron	154-158	guanine nucleotide exchange factor SDO1	Saccharomyces cerevisiae S288C	17-22
32944219-7	2020	In addition, the low activity of manganese superoxide dismutase (Sod2p) seen in sdo1  cells was improved with iron chelation, consistent with the presence of reactive iron from the ISC assembly pathway.	Iron	110-114	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	65-70
32944219-7	2020	In addition, the low activity of manganese superoxide dismutase (Sod2p) seen in sdo1  cells was improved with iron chelation, consistent with the presence of reactive iron from the ISC assembly pathway.	Iron	110-114	guanine nucleotide exchange factor SDO1	Saccharomyces cerevisiae S288C	80-84
32944219-7	2020	In addition, the low activity of manganese superoxide dismutase (Sod2p) seen in sdo1  cells was improved with iron chelation, consistent with the presence of reactive iron from the ISC assembly pathway.	Iron	167-171	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	65-70
32944219-7	2020	In addition, the low activity of manganese superoxide dismutase (Sod2p) seen in sdo1  cells was improved with iron chelation, consistent with the presence of reactive iron from the ISC assembly pathway.	Iron	167-171	guanine nucleotide exchange factor SDO1	Saccharomyces cerevisiae S288C	80-84
32227503-4	2020	More importantly, the Fe 4 M 2 molecules constitute a unique example where the presence of the guests directly affects the pressure-induced thermal spin crossover (SCO) phenomenon occurring at the Fe II centers.	Iron	22-24	spindlin 1	Homo sapiens	148-152
23160767-3	2012	In order to investigate the role of ESA on iron metabolism, we analyzed the regulation of the iron regulatory hormone hepcidin by ESA treatment in a bone marrow transplant model in mouse.	Iron	94-98	hepcidin antimicrobial peptide	Mus musculus	118-126
31132412-1	2020	N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that is regulated by hypoxia, metal ions including iron, the free radical nitric oxide (NO.	Iron	127-131	N-myc downstream regulated 1	Homo sapiens	0-33
23052953-10	2012	Among screened VF genes, iroN and sfa appeared important for lung infection.	Iron	25-29	virulence factor	Escherichia coli	15-17
31132412-1	2020	N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that is regulated by hypoxia, metal ions including iron, the free radical nitric oxide (NO.	Iron	127-131	N-myc downstream regulated 1	Homo sapiens	35-40
22560353-0	2012	The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	28-36
22560353-0	2012	The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	28-36
22560353-1	2012	The mechanism by which hepcidin controls cellular iron release protein ferroportin 1 (Fpn1) in macrophages has been well established.	Iron	50-54	hepcidin antimicrobial peptide	Mus musculus	23-31
22560353-2	2012	However, little is known about the effects of hepcidin on cellular iron uptake proteins.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	46-54
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	222-226	hepcidin antimicrobial peptide	Mus musculus	46-54
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	253-257	hepcidin antimicrobial peptide	Mus musculus	46-54
31132412-8	2020	also inducing NDRG1 through its ability to bind iron and generate dinitrosyl-dithiol iron complexes, which are then effluxed from cells.	Iron	48-52	N-myc downstream regulated 1	Homo sapiens	14-19
22560353-3	2012	Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages.	Iron	253-257	hepcidin antimicrobial peptide	Mus musculus	46-54
23045394-6	2012	The mitochondrial transporter Atm1p, which has been implicated in the export of iron-sulfur clusters and related molecules, is required not only for iron binding to Grx3p but also for dissociation of Aft1p from its target promoters.	Iron	80-84	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	165-170
32022258-11	2020	For example, higher dietary iron was most strongly associated with increased breast cancer risk among women with GSTT1 deletion or GSTM1/GSTT1 double deletions (pinteraction  < 0.05).	Iron	28-32	glutathione S-transferase theta 1	Homo sapiens	113-118
23045394-6	2012	The mitochondrial transporter Atm1p, which has been implicated in the export of iron-sulfur clusters and related molecules, is required not only for iron binding to Grx3p but also for dissociation of Aft1p from its target promoters.	Iron	80-84	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	200-205
23045394-6	2012	The mitochondrial transporter Atm1p, which has been implicated in the export of iron-sulfur clusters and related molecules, is required not only for iron binding to Grx3p but also for dissociation of Aft1p from its target promoters.	Iron	149-153	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	165-170
23045394-7	2012	These results suggest that iron binding to Grx3p (and presumably Grx4p) is a prerequisite for the suppression of Aft1p.	Iron	27-31	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	43-48
23045394-7	2012	These results suggest that iron binding to Grx3p (and presumably Grx4p) is a prerequisite for the suppression of Aft1p.	Iron	27-31	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	113-118
32022258-11	2020	For example, higher dietary iron was most strongly associated with increased breast cancer risk among women with GSTT1 deletion or GSTM1/GSTT1 double deletions (pinteraction  < 0.05).	Iron	28-32	glutathione S-transferase theta 1	Homo sapiens	137-142
22809528-2	2012	Frataxin (FXN) is associated with iron homeostasis and biogenesis of iron-sulfur clusters in the electron transport chain complex.	Iron	34-38	frataxin	Mus musculus	0-8
32754933-0	2020	Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107.	Iron	0-4	homeostatic iron regulator	Mus musculus	114-117
22809528-2	2012	Frataxin (FXN) is associated with iron homeostasis and biogenesis of iron-sulfur clusters in the electron transport chain complex.	Iron	34-38	frataxin	Mus musculus	10-13
22809528-2	2012	Frataxin (FXN) is associated with iron homeostasis and biogenesis of iron-sulfur clusters in the electron transport chain complex.	Iron	69-73	frataxin	Mus musculus	0-8
22809528-2	2012	Frataxin (FXN) is associated with iron homeostasis and biogenesis of iron-sulfur clusters in the electron transport chain complex.	Iron	69-73	frataxin	Mus musculus	10-13
32754933-0	2020	Iron promotes the clearance of alpha-synuclein: An Editorial for "H63D variant of the homeostatic iron regulator (HFE) gene alters alpha-synuclein expression, aggregation, and toxicity" on https://doi.org/10.1111/jnc.15107.	Iron	98-102	homeostatic iron regulator	Mus musculus	114-117
32754933-4	2020	have shown that the H63D variant of the homeostatic iron regulator (HFE) facilitates alpha-syn degradation via REDD1-mediated autophagy.	Iron	52-56	homeostatic iron regulator	Mus musculus	68-71
32506000-4	2020	The performance of the setup was tested on ferromagnetic Fe nanoscale islands on a W(110) single crystal, with spatial resolution of 3.3 nm in spin asymmetry images.	Iron	57-59	spindlin 1	Homo sapiens	143-147
22977270-12	2012	A decreased level of the iron-sulfur-containing protein SDHB was found by immunohistochemical analysis performed in two of these tumors.	Iron	25-29	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	56-60
32831652-13	2020	Moreover, iron upregulated the expression of mitoferrin 1 (SLC25A37) and mitoferrin 2 (SLC25A28).	Iron	10-14	solute carrier family 25 member 37	Homo sapiens	45-57
22584950-0	2012	C19orf12 mutations in neurodegeneration with brain iron accumulation mimicking juvenile amyotrophic lateral sclerosis.	Iron	51-55	chromosome 19 open reading frame 12	Homo sapiens	0-8
22584950-1	2012	Mutations in C19orf12 have been recently identified as the molecular genetic cause of a subtype of neurodegeneration with brain iron accumulation (NBIA).	Iron	128-132	chromosome 19 open reading frame 12	Homo sapiens	13-21
32831652-13	2020	Moreover, iron upregulated the expression of mitoferrin 1 (SLC25A37) and mitoferrin 2 (SLC25A28).	Iron	10-14	solute carrier family 25 member 37	Homo sapiens	59-67
22997041-6	2012	Ferritin heavy chain 1 (FTH1) was identified as a candidate gene, which is involved in iron metabolism and iron depletion significantly decreased the self-renewal of CSCs.	Iron	87-91	ferritin heavy polypeptide 1	Mus musculus	0-22
22997041-6	2012	Ferritin heavy chain 1 (FTH1) was identified as a candidate gene, which is involved in iron metabolism and iron depletion significantly decreased the self-renewal of CSCs.	Iron	87-91	ferritin heavy polypeptide 1	Mus musculus	24-28
32831652-13	2020	Moreover, iron upregulated the expression of mitoferrin 1 (SLC25A37) and mitoferrin 2 (SLC25A28).	Iron	10-14	solute carrier family 25 member 28	Homo sapiens	73-85
22997041-6	2012	Ferritin heavy chain 1 (FTH1) was identified as a candidate gene, which is involved in iron metabolism and iron depletion significantly decreased the self-renewal of CSCs.	Iron	107-111	ferritin heavy polypeptide 1	Mus musculus	0-22
32831652-13	2020	Moreover, iron upregulated the expression of mitoferrin 1 (SLC25A37) and mitoferrin 2 (SLC25A28).	Iron	10-14	solute carrier family 25 member 28	Homo sapiens	87-95
22997041-6	2012	Ferritin heavy chain 1 (FTH1) was identified as a candidate gene, which is involved in iron metabolism and iron depletion significantly decreased the self-renewal of CSCs.	Iron	107-111	ferritin heavy polypeptide 1	Mus musculus	24-28
22789477-1	2012	Human Lactoferrin (hLF) is an iron-binding protein with multiple physiological functions.	Iron	30-34	lactotransferrin	Capra hircus	6-17
32831652-15	2020	In addition, iron increased the expression of Warburg key enzymes HK2 and Glut1, and affected AMPK/mTORC1 signaling axis.	Iron	13-17	solute carrier family 2 member 1	Homo sapiens	74-79
32636300-0	2020	Cardiolipin-deficient cells have decreased levels of the iron-sulfur biogenesis protein frataxin.	Iron	57-61	frataxin	Mus musculus	88-96
32636300-8	2020	We observed decreased levels of Yfh1/frataxin, an essential component of the iron-sulfur biogenesis machinery, in mitochondria from TAZ-KO mouse cells and in CL-deleted yeast crd1Delta cells, indicating that the role of CL in iron-sulfur biogenesis is highly conserved.	Iron	77-81	ferroxidase	Saccharomyces cerevisiae S288C	32-36
32636300-8	2020	We observed decreased levels of Yfh1/frataxin, an essential component of the iron-sulfur biogenesis machinery, in mitochondria from TAZ-KO mouse cells and in CL-deleted yeast crd1Delta cells, indicating that the role of CL in iron-sulfur biogenesis is highly conserved.	Iron	77-81	frataxin	Mus musculus	37-45
23009692-2	2012	Compound {Fe(MeOH)(2)[Pd(SCN)(4)]} pz (1a) is a two-dimensional coordination polymer where the Fe(II) ions are equatorially coordinated by the nitrogen atoms of four [Pd(SCN)(4)](2-) anions, each of which connects four Fe(II) ions, forming corrugated layers {Fe[Pd(SCN)(4)]}( ).	Iron	10-12	sorcin	Homo sapiens	25-28
32823844-0	2020	The Role of Iron and Erythropoietin in the Association of Fibroblast Growth Factor 23 with Anemia in Chronic Kidney Disease in Humans.	Iron	12-16	fibroblast growth factor 23	Homo sapiens	58-85
23009692-2	2012	Compound {Fe(MeOH)(2)[Pd(SCN)(4)]} pz (1a) is a two-dimensional coordination polymer where the Fe(II) ions are equatorially coordinated by the nitrogen atoms of four [Pd(SCN)(4)](2-) anions, each of which connects four Fe(II) ions, forming corrugated layers {Fe[Pd(SCN)(4)]}( ).	Iron	10-12	sorcin	Homo sapiens	170-173
23009692-2	2012	Compound {Fe(MeOH)(2)[Pd(SCN)(4)]} pz (1a) is a two-dimensional coordination polymer where the Fe(II) ions are equatorially coordinated by the nitrogen atoms of four [Pd(SCN)(4)](2-) anions, each of which connects four Fe(II) ions, forming corrugated layers {Fe[Pd(SCN)(4)]}( ).	Iron	10-12	sorcin	Homo sapiens	170-173
22975354-3	2012	Real-time PCR analyses of the human PDL revealed abundant expression of ferritin light polypeptide (FTL) and ferritin heavy polypeptide (FTH), which encode the highly-conserved iron storage protein, ferritin.	Iron	177-181	ferritin light chain	Homo sapiens	72-98
22975354-3	2012	Real-time PCR analyses of the human PDL revealed abundant expression of ferritin light polypeptide (FTL) and ferritin heavy polypeptide (FTH), which encode the highly-conserved iron storage protein, ferritin.	Iron	177-181	ferritin light chain	Homo sapiens	100-103
32687329-11	2020	Complex 14 can be treated with an excess of NaBH4 to give the hydride complex [Fe(H)(NP3)(CO)][BPh4] (15), which can further be deprotonated/reduced to the Fe(0) complex Fe(NP3)(CO) (16) upon treatment with an excess of KH.	Iron	156-161	leukemia NUP98 fusion partner 1	Homo sapiens	85-88
22858058-9	2012	Iron deposition in the pancreas and heart occurred after maximal iron loading of the liver was reached and was most marked in the Hfe(-/-)/Tfr2(-/-) mice.	Iron	0-4	homeostatic iron regulator	Mus musculus	130-133
22858058-9	2012	Iron deposition in the pancreas and heart occurred after maximal iron loading of the liver was reached and was most marked in the Hfe(-/-)/Tfr2(-/-) mice.	Iron	0-4	transferrin receptor 2	Mus musculus	139-143
32687329-11	2020	Complex 14 can be treated with an excess of NaBH4 to give the hydride complex [Fe(H)(NP3)(CO)][BPh4] (15), which can further be deprotonated/reduced to the Fe(0) complex Fe(NP3)(CO) (16) upon treatment with an excess of KH.	Iron	156-161	leukemia NUP98 fusion partner 1	Homo sapiens	173-176
32251724-4	2020	Supplementation with exogenous unsaturated fatty acids (UFAs) or OLE1 expression rescues the iron regulon activation defect of mga2Delta cells.	Iron	93-97	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	65-69
22528770-4	2012	The expression of genes involved in iron intestinal absorption (divalent metal transporter 1, duodenal cytochrome B, ferroportin 1 FPN1, and ferritin) were evaluated in vitro by treating Caco-2 cells with retinoic acid or in vivo by observing the effects of vitamin A deficiency (VAD) in BALB/C mice.	Iron	36-40	cytochrome b reductase 1	Homo sapiens	94-115
22580926-3	2012	The iron regulatory protein 2 (Irp2) and one of the genes mutated in hereditary hemochromatosis Hfe , are both proteins involved in the regulation of systemic iron homeostasis.	Iron	4-8	iron responsive element binding protein 2	Mus musculus	31-35
32251724-6	2020	Subcellular localization studies reveal that low UFAs cause a mislocalization of Aft1 protein to the vacuole upon iron deprivation that prevents its nuclear accumulation.	Iron	114-118	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	81-85
22580926-3	2012	The iron regulatory protein 2 (Irp2) and one of the genes mutated in hereditary hemochromatosis Hfe , are both proteins involved in the regulation of systemic iron homeostasis.	Iron	4-8	homeostatic iron regulator	Mus musculus	96-99
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	129-133	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	37-41
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	129-133	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	96-100
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	157-161	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	37-41
22817335-4	2012	Iron (FeSO4) administration also disrupted Bcl-2/Bad protein balance, reduced mitochondrial membrane potential, released cytochrome c and induced the activation of caspases and cleavage of PARP protein.	Iron	0-4	poly (ADP-ribose) polymerase family, member 1	Mus musculus	189-193
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	157-161	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	96-100
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	157-161	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	37-41
32251724-7	2020	These results indicate that Mga2 and Ole1 are essential to maintain the UFA levels required for Aft1-dependent activation of the iron regulon in response to iron deficiency, and directly connect the biosynthesis of fatty acids to the response to iron depletion.	Iron	157-161	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	96-100
22677540-7	2012	It also restored to control levels the values of transferrin-bound Fe and the total iron binding capacity (TIBC) of the plasma.	Iron	67-69	transferrin	Mus musculus	49-60
32430665-14	2020	In vitro experiments showed that iron content was reduced, and lipopolysaccharide-induced Tnf-alpha (also known as Tnf) mRNA upregulation was inhibited in a macrophage cell line transfected with Fth siRNA.	Iron	33-37	ferritin heavy polypeptide 1	Mus musculus	195-198
32480029-0	2020	Pinewood outperformed bamboo as feedstock to prepare biochar-supported zero-valent iron for Cr6+ reduction.	Iron	83-87	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	92-95
22869521-1	2012	Hepcidin is a liver-derived peptide hormone and the master regulator of systemic iron homeostasis.	Iron	81-85	hepcidin antimicrobial peptide	Mus musculus	0-8
22869521-3	2012	Dysregulation of hepcidin signaling in ALD leads to liver iron deposition, which is a major contributing factor to liver injury.	Iron	58-62	hepcidin antimicrobial peptide	Mus musculus	17-25
22957710-6	2012	These efforts have been boosted by recent reports of the crystal structures of the neisserial receptor proteins TbpA and TbpB, each solved in complex with human transferrin, an iron binding protein normally responsible for delivering iron to human cells.	Iron	177-181	transthyretin	Homo sapiens	112-116
31778583-1	2020	Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	131-139
22957710-6	2012	These efforts have been boosted by recent reports of the crystal structures of the neisserial receptor proteins TbpA and TbpB, each solved in complex with human transferrin, an iron binding protein normally responsible for delivering iron to human cells.	Iron	234-238	transthyretin	Homo sapiens	112-116
31930323-0	2020	Novel use of burosumab in refractory iron-induced FGF23-mediated hypophosphataemic osteomalacia.	Iron	37-41	fibroblast growth factor 23	Homo sapiens	50-55
23030111-1	2012	We study the mechanism of orbital or spin fluctuations due to multiorbital Coulomb interaction in iron-based superconductors, going beyond the random-phase approximation.	Iron	98-102	spindlin 1	Homo sapiens	37-41
22950847-8	2012	For example, oxidation of 1 or 5 with Pb(OAc)(4) results in disproportionation of the N(2)H(x) ligand (x = 3, 4), and formation of [PhBP(R)(3)]Fe(NH(3))(OAc) (R = Ph (9) and mter (11)).	Iron	143-145	hyaluronan binding protein 2	Homo sapiens	132-136
22678064-0	2012	Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in Btbd9 mutant mice.	Iron	87-91	BTB (POZ) domain containing 9	Mus musculus	102-107
32675368-0	2020	Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis.	Iron	52-56	lipocalin 2	Homo sapiens	20-31
22678064-7	2012	Additionally, the Btbd9 mutant mice had altered serum iron levels and monoamine neurotransmitter systems.	Iron	54-58	BTB (POZ) domain containing 9	Mus musculus	18-23
32675368-4	2020	We found that cancer cells, but not macrophages, within the CSF express the iron-binding protein lipocalin-2 (LCN2) and its receptor SCL22A17.	Iron	76-80	lipocalin 2	Homo sapiens	97-108
22829592-0	2012	Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation.	Iron	107-111	TNF receptor associated factor 6	Rattus norvegicus	71-76
22829592-2	2012	Our earlier work demonstrates the role of ferrous iron (Fe(2+)) as a pathogen-associated molecular pattern-independent agonist for activation of IkappaB kinase (IKK) and NF-kappaB in HM via activation and interaction of p21(ras), transforming growth factor beta-activated kinase-1 (TAK1), and phosphatidylinositol 3-kinase (PI3K) in caveosomes.	Iron	50-54	KRAS proto-oncogene, GTPase	Rattus norvegicus	220-223
32675368-4	2020	We found that cancer cells, but not macrophages, within the CSF express the iron-binding protein lipocalin-2 (LCN2) and its receptor SCL22A17.	Iron	76-80	lipocalin 2	Homo sapiens	110-114
22829592-2	2012	Our earlier work demonstrates the role of ferrous iron (Fe(2+)) as a pathogen-associated molecular pattern-independent agonist for activation of IkappaB kinase (IKK) and NF-kappaB in HM via activation and interaction of p21(ras), transforming growth factor beta-activated kinase-1 (TAK1), and phosphatidylinositol 3-kinase (PI3K) in caveosomes.	Iron	50-54	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	230-280
22829592-2	2012	Our earlier work demonstrates the role of ferrous iron (Fe(2+)) as a pathogen-associated molecular pattern-independent agonist for activation of IkappaB kinase (IKK) and NF-kappaB in HM via activation and interaction of p21(ras), transforming growth factor beta-activated kinase-1 (TAK1), and phosphatidylinositol 3-kinase (PI3K) in caveosomes.	Iron	50-54	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	282-286
32164430-0	2020	Elevated Labile Iron Levels in CD4 and CD8 T Cells From HIV Positive Individuals With Undetectable Viral Load.	Iron	16-20	CD8a molecule	Homo sapiens	39-42
22897320-1	2012	Human ferrochelatase (EC 4.99.1.1) catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis, an essential process to most organisms given the vast intracellular functions of heme.	Iron	67-71	ferrochelatase	Homo sapiens	6-20
22897320-1	2012	Human ferrochelatase (EC 4.99.1.1) catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis, an essential process to most organisms given the vast intracellular functions of heme.	Iron	67-71	ferrochelatase	Homo sapiens	22-33
32452919-0	2020	Simultaneous management of disordered phosphate and iron homeostasis to correct fibroblast growth factor 23 and associated outcomes in chronic kidney disease.	Iron	52-56	fibroblast growth factor 23	Homo sapiens	80-107
22897320-2	2012	Even with multiple ferrochelatase structures available, the exact mechanism for iron insertion into porphyrin is still a matter for debate.	Iron	80-84	ferrochelatase	Homo sapiens	19-33
22897320-10	2012	These results provide a rigorous view of the ferrochelatase mechanism through the inclusion of dynamic information, reveal new structural areas for functional investigation, and offer new insight into a potential iron channel to the active site.	Iron	213-217	ferrochelatase	Homo sapiens	45-59
32452919-2	2020	In this manuscript, we put in perspective the newest insights on FGF23 regulation by iron and phosphate and their effects on CKD progression and associated outcomes.	Iron	85-89	fibroblast growth factor 23	Homo sapiens	65-70
32179427-0	2020	A mitophagic response to iron overload-induced oxidative damage associated with the PINK1/Parkin pathway in pancreatic beta cells.	Iron	25-29	PTEN induced kinase 1	Rattus norvegicus	84-89
22728330-5	2012	Structure-function studies, imaging studies and clinical studies have revealed that NGAL-Siderocalin is an endogenous antimicrobial with iron scavenging activity.	Iron	137-141	lipocalin 2	Homo sapiens	84-88
32179427-10	2020	CONCLUSIONS: We proved that increased iron overload primarily increased oxidative stress and further suppressed mitophagy via PTEN-induced putative kinase 1/Parkin pathway, resulting in cytotoxicity in INS-1 cells.	Iron	38-42	PTEN induced kinase 1	Rattus norvegicus	126-156
22855532-3	2012	Rli1p (ABCE1) is an essential and highly conserved protein of eukaryotes and archaea that requires notoriously ROS-labile cofactors (Fe-S clusters) for its functions in protein synthesis.	Iron	133-137	ATP binding cassette subfamily E member 1	Homo sapiens	0-5
22855532-3	2012	Rli1p (ABCE1) is an essential and highly conserved protein of eukaryotes and archaea that requires notoriously ROS-labile cofactors (Fe-S clusters) for its functions in protein synthesis.	Iron	133-137	ATP binding cassette subfamily E member 1	Homo sapiens	7-12
22855532-9	2012	Instead, it was primarily (55)FeS-cluster supply to Rli1p that was defective in prooxidant-exposed cells.	Iron	30-33	ATP binding cassette subfamily E member 1	Homo sapiens	52-57
32304700-5	2020	Here, we describe the identification, maturation, characterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a native receptor and BBB transporter for the iron chaperone transferrin.	Iron	185-189	transferrin	Mus musculus	111-122
22511606-1	2012	AtNfs1 is the Arabidopsis thaliana mitochondrial homolog of the bacterial cysteine desulfurases NifS and IscS, having an essential role in cellular Fe-S cluster assembly.	Iron	148-152	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	0-6
22511606-7	2012	Results suggest that AtFH plays an important role in the early steps of Fe-S cluster formation by regulating AtNfs1 activity in plant mitochondria.	Iron	72-76	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	109-115
32366593-11	2020	The transferrin binding proteins, TbpA and TbpB, are thought to be a key iron acquisition system in H. somni; however, despite their importance, H. somni TbpA and TbpB were previously shown to be cattle transferrin-specific.	Iron	73-77	transthyretin	Homo sapiens	34-38
22829206-1	2012	Plant heme oxygenase (HO) catalyzes the oxygenation of heme to biliverdin, carbon monoxide (CO), and free iron (Fe(2+))-and Arabidopsis and rice (Oryza sativa) HOs are involved in light signaling.	Iron	106-110	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	6-20
32656436-4	2020	Spin polarization of MoS2 is gradually induced when Fe approaches the surface and eliminated when Fe roams around a potential energy trap on the MoS2 layer.	Iron	52-54	spindlin 1	Homo sapiens	0-4
22886498-0	2012	Glutathione regulates the transfer of iron-sulfur cluster from monothiol and dithiol glutaredoxins to apo ferredoxin.	Iron	38-42	ferredoxin 1	Homo sapiens	106-116
22789928-12	2012	The MMP-9 and EGF upregulation was linked to the presence of iron deposition in both groups, whereas increased levels of EGF were connected with the presence of myopic regression after LASIK.	Iron	61-65	matrix metallopeptidase 9	Homo sapiens	4-9
32656436-4	2020	Spin polarization of MoS2 is gradually induced when Fe approaches the surface and eliminated when Fe roams around a potential energy trap on the MoS2 layer.	Iron	98-100	spindlin 1	Homo sapiens	0-4
22789928-15	2012	MMP-9 was significantly higher in tears of subjects presenting iron deposition after OK or LASIK, and EGF levels seemed to play an important role in postoperative refractive outcomes after LASIK.	Iron	63-67	matrix metallopeptidase 9	Homo sapiens	0-5
32374339-2	2020	Here, we investigated the sorption of Fe2+ onto a synthetic montmorillonite (Syn-1) low in structural Fe (<0.05 mmol Fe per kg) under anoxic conditions and the effects of subsequent oxidation.	Iron	102-104	synapsin I	Homo sapiens	77-82
32545266-1	2020	Hepatic peptide hormone hepcidin, a key regulator of iron metabolism, is induced by inflammatory cytokine interleukin-6 (IL-6) in the pathogenesis of anemia of inflammation or microbial infections.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	24-32
22552855-5	2012	The isotopic evidence indicates that Iron Age diet consisted of C(3) foodstuffs with no isotopic evidence for the consumption of C(4) or marine resources.	Iron	37-41	complement C3	Homo sapiens	64-68
22294463-3	2012	Patients and mice deficient in transferrin exhibit anemia and a paradoxical iron overload attributed to deficiency in hepcidin, a peptide hormone synthesized largely by the liver that inhibits dietary iron absorption and macrophage iron efflux.	Iron	76-80	transferrin	Mus musculus	31-42
22294463-3	2012	Patients and mice deficient in transferrin exhibit anemia and a paradoxical iron overload attributed to deficiency in hepcidin, a peptide hormone synthesized largely by the liver that inhibits dietary iron absorption and macrophage iron efflux.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	118-126
32209423-8	2020	Decreased levels of TfR1 and FTL proteins observed in HuA treated CIH group, could reduce iron overload in hippocampus.	Iron	90-94	ferritin light polypeptide 1	Mus musculus	29-32
22294463-3	2012	Patients and mice deficient in transferrin exhibit anemia and a paradoxical iron overload attributed to deficiency in hepcidin, a peptide hormone synthesized largely by the liver that inhibits dietary iron absorption and macrophage iron efflux.	Iron	201-205	transferrin	Mus musculus	31-42
22294463-3	2012	Patients and mice deficient in transferrin exhibit anemia and a paradoxical iron overload attributed to deficiency in hepcidin, a peptide hormone synthesized largely by the liver that inhibits dietary iron absorption and macrophage iron efflux.	Iron	201-205	hepcidin antimicrobial peptide	Mus musculus	118-126
22294463-3	2012	Patients and mice deficient in transferrin exhibit anemia and a paradoxical iron overload attributed to deficiency in hepcidin, a peptide hormone synthesized largely by the liver that inhibits dietary iron absorption and macrophage iron efflux.	Iron	201-205	transferrin	Mus musculus	31-42
22294463-3	2012	Patients and mice deficient in transferrin exhibit anemia and a paradoxical iron overload attributed to deficiency in hepcidin, a peptide hormone synthesized largely by the liver that inhibits dietary iron absorption and macrophage iron efflux.	Iron	201-205	hepcidin antimicrobial peptide	Mus musculus	118-126
32476270-10	2020	Thus, improvement of iron utilization in a CKD model using EPO and a HIF-PHDi significantly reduced iFGF23, demonstrating that anemia is a primary driver of FGF23, and that management of iron utilization in patients with CKD may translate to modifiable outcomes in mineral metabolism.	Iron	21-25	fibroblast growth factor 23	Homo sapiens	101-106
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	46-48	mitofusin 2	Homo sapiens	194-199
22476617-11	2012	Thus, high Fe, inflammation, and hypoxia trigger the expression of genes related to inflammation and Fe metabolism in HepG2 cells, in 3T3-L1 cells the same stimuli increased NF-kB and hepcidin expression.	Iron	11-13	hepcidin antimicrobial peptide	Mus musculus	184-192
32557515-4	2020	The discovery of hepcidin as being an important regulative protein made a hormone-like regulation of the Fe metabolism evident.	Iron	105-107	hepcidin antimicrobial peptide	Sus scrofa	17-25
22367974-9	2012	Iron repletion at P21, near the end of hippocampal dendritogenesis, restored spatial memory, dendrite structure, and critical period markers in adult mice.	Iron	0-4	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	18-21
22367974-11	2012	Together, these findings demonstrate that hippocampal iron availability is necessary between P21 and P42 for development of normal spatial learning and memory, and that these effects may reflect disruption of critical period closure by early life ID.	Iron	54-58	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	93-96
22383097-0	2012	Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.	Iron	72-76	transferrin receptor 2	Mus musculus	42-64
22383097-7	2012	Hfe(-/-) xTfr2(mut) mice had elevated hepatic iron with a periportal distribution and increased plasma iron, transferrin saturation, and non-transferrin-bound iron, compared with Hfe(-/-), Tfr2(mut), and wild-type (WT) mice.	Iron	46-50	homeostatic iron regulator	Mus musculus	0-3
22383097-7	2012	Hfe(-/-) xTfr2(mut) mice had elevated hepatic iron with a periportal distribution and increased plasma iron, transferrin saturation, and non-transferrin-bound iron, compared with Hfe(-/-), Tfr2(mut), and wild-type (WT) mice.	Iron	103-107	homeostatic iron regulator	Mus musculus	0-3
22634302-9	2012	Inhibition of eIF3A and La proteins substantially repressed iron-dependent HCV translation, a beneficial effect that may have significant clinical implications.	Iron	60-64	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	14-19
22712763-1	2012	Ferrochelatase catalyzes the formation of protoheme from two potentially cytotoxic products, iron and protoporphyrin IX.	Iron	93-97	ferrochelatase	Homo sapiens	0-14
22768841-4	2012	Inhibition of sphingolipid synthesis by myriocin treatment or after overexpression of the negative regulator Orm2p confers resistance to high iron.	Iron	142-146	sphingolipid homeostasis protein ORM2	Saccharomyces cerevisiae S288C	109-114
22768841-5	2012	High iron conditions upregulate sphingolipid synthesis, and increasing sphingolipid levels by inactivating Orm2p exacerbates sensitivity to iron.	Iron	140-144	sphingolipid homeostasis protein ORM2	Saccharomyces cerevisiae S288C	107-112
22465035-0	2012	Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis.	Iron	53-57	homeostatic iron regulator	Mus musculus	120-123
22465035-0	2012	Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis.	Iron	82-86	homeostatic iron regulator	Mus musculus	120-123
22465035-1	2012	Quantitative analysis of the temperature dependent AC magnetic susceptibility of freeze-dried mouse tissues from an Hfe hereditary haemochromatosis disease model indicates that iron predominantly appears biomineralised, like in the ferritin cores, in the liver, the spleen and duodenum.	Iron	177-181	homeostatic iron regulator	Mus musculus	116-119
22547548-3	2012	In this investigation, yeast two-hybrid analysis demonstrated that an E. chaffeensis type 1 secretion system substrate, TRP32, interacts with a diverse group of human proteins associated with major biological processes of the host cell, including protein synthesis, trafficking, degradation, immune signaling, cell signaling, iron metabolism, and apoptosis.	Iron	326-330	thioredoxin like 1	Homo sapiens	120-125
22517766-3	2012	We took advantage of the low iron status of juvenile mice to characterize the regulation of Bmp6 and Hamp1 expression by iron administered in three forms: 1) ferri-transferrin (Fe-Tf), 2) ferric ammonium citrate (FAC), and 3) liver ferritin.	Iron	121-125	hepcidin antimicrobial peptide	Mus musculus	101-106
22517766-12	2012	We conclude that exogenous iron-containing ferritin upregulates hepatic Bmp6 expression, and we speculate that liver ferritin contributes to regulation of Bmp6 and, thus, Hamp1 genes.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	171-176
22460705-2	2012	Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in systemic iron overload.	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	75-83
22460705-2	2012	Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in systemic iron overload.	Iron	130-134	hepcidin antimicrobial peptide	Mus musculus	75-83
22460705-2	2012	Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in systemic iron overload.	Iron	130-134	hepcidin antimicrobial peptide	Mus musculus	75-83
22460705-8	2012	In conclusion, we demonstrate that Tfr2 is not essential for Hfe-mediated induction of hepcidin expression, supporting the possibility that TFR2 may regulate iron metabolism in an HFE-independent manner.	Iron	158-162	transferrin receptor 2	Mus musculus	140-144
22490684-2	2012	HAMP expression is activated by iron through the bone morphogenetic protein (BMP)-son of mothers against decapentaplegic signaling pathway and inhibited by ineffective erythropoiesis through an unknown "erythroid regulator."	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	0-4
22490684-4	2012	Here, we show that homozygous loss of Tmprss6 in Hbb(th3/+) mice improves anemia and reduces ineffective erythropoiesis, splenomegaly, and iron loading.	Iron	139-143	hemoglobin beta chain complex	Mus musculus	49-52
22490684-5	2012	All these effects are mediated by Hamp up-regulation, which inhibits iron absorption and recycling.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	34-38
22490684-8	2012	Our study indicates that preventing iron overload improves beta-thalassemia and strengthens the essential role of Tmprss6 for Hamp suppression, providing a proof of concept that Tmprss6 manipulation can offer a novel therapeutic option in this condition.	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	126-130
22383495-1	2012	The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane.	Iron	76-80	RoBo-1	Rattus norvegicus	4-32
22383495-1	2012	The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane.	Iron	76-80	RoBo-1	Rattus norvegicus	34-38
22383495-1	2012	The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane.	Iron	92-96	RoBo-1	Rattus norvegicus	4-32
22383495-1	2012	The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane.	Iron	92-96	RoBo-1	Rattus norvegicus	34-38
22383495-2	2012	We have previously shown that with iron feeding DMT1 in the brush border membrane undergoes endocytosis into the subapical compartment of enterocytes.	Iron	35-39	RoBo-1	Rattus norvegicus	48-52
22348978-3	2012	Previous studies of ferritin formed with p.Phe167SerfsX26 mutant FTL (Mt-FTL) subunits found disordered 4-fold pores, iron mishandling, and proaggregative behavior, as well as a general increase in cellular oxidative stress when expressed in vivo.	Iron	118-122	ferritin light chain	Homo sapiens	65-68
22348978-4	2012	Herein, we demonstrate that Mt-FTL is also a target of iron-catalyzed oxidative damage in vitro and in vivo.	Iron	55-59	ferritin light chain	Homo sapiens	31-34
22457016-11	2012	VMB expression differences of Glt1 in six strains covary with differential susceptibility to VMB iron loss.	Iron	97-101	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	30-34
22589187-11	2012	Interestingly, nuclear import of Nuclear factor kappa B (NFkappaB) and its activity were found to be affected by the decreased Nup153 in iron stimulated HepG2.2.15 cells.	Iron	137-141	nucleoporin 153	Homo sapiens	127-133
22370144-0	2012	Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading.	Iron	73-77	homeostatic iron regulator	Mus musculus	41-44
22370144-4	2012	The Hfe(-/-) mouse brain showed numerous significant changes in transcript levels (p&lt;0.05) although few of these related to proteins directly involved in iron homeostasis.	Iron	157-161	homeostatic iron regulator	Mus musculus	4-7
22366979-2	2012	While cooperativity is barely predictable in solids, we show here that solution processing and the covalent introduction of molecular recognition sites allows the spin crossover of iron(III) sal(2)trien complexes to be rationally tuned.	Iron	181-185	spindlin 1	Homo sapiens	163-167
22170436-0	2012	Ferroportin 1 and hephaestin expression in BeWo cell line with different iron treatment.	Iron	73-77	hephaestin	Homo sapiens	18-28
22170436-3	2012	Ferroportin 1 (FPN1) and hephaestin (Heph) have been identified as the important molecules involved in duodenal iron export.	Iron	112-116	hephaestin	Homo sapiens	25-35
22170436-3	2012	Ferroportin 1 (FPN1) and hephaestin (Heph) have been identified as the important molecules involved in duodenal iron export.	Iron	112-116	hephaestin	Homo sapiens	37-41
32557515-6	2020	An increase of hepcidin leads to a decrease of Fe export from the cell into the extracellular space, the consequence being an internalisation of Fe in the reticuloendothelial system as well as in mononuclear cells.	Iron	47-49	hepcidin antimicrobial peptide	Sus scrofa	15-23
32557515-6	2020	An increase of hepcidin leads to a decrease of Fe export from the cell into the extracellular space, the consequence being an internalisation of Fe in the reticuloendothelial system as well as in mononuclear cells.	Iron	145-147	hepcidin antimicrobial peptide	Sus scrofa	15-23
32557515-8	2020	The induction of hepatic hepcidin synthesis seems to be caused by high Fe- and transferrin concentrations in plasma.	Iron	71-73	hepcidin antimicrobial peptide	Sus scrofa	25-33
32557515-10	2020	This finding offers an explanation for the frequently observed decrease of Fe in serum/plasma during acute inflammation, the mechanism thus being termed as cytokine-hepcidin-link.	Iron	75-77	hepcidin antimicrobial peptide	Sus scrofa	165-173
32564678-7	2020	The blood levels of sodium (Na+), iron (Fe2+), and calcium (Ca2+) were decreased in Gp3, Gp4, and Gp5 due to the chelating effects of EDTA.	Iron	34-38	glycoprotein 5 (platelet)	Mus musculus	98-101
31869199-2	2020	Human cells release the innate immune protein siderocalin (Scn, also known as lipocalin-2/Lcn2, neutrophil gelatinase-associated lipocalin/NGAL) that can inhibit bacterial growth by sequestering iron in a ferric complex with enterobactin (Ent), the ubiquitous Escherichia coli siderophore.	Iron	195-199	lipocalin 2	Homo sapiens	78-89
31869199-2	2020	Human cells release the innate immune protein siderocalin (Scn, also known as lipocalin-2/Lcn2, neutrophil gelatinase-associated lipocalin/NGAL) that can inhibit bacterial growth by sequestering iron in a ferric complex with enterobactin (Ent), the ubiquitous Escherichia coli siderophore.	Iron	195-199	lipocalin 2	Homo sapiens	90-94
31869199-2	2020	Human cells release the innate immune protein siderocalin (Scn, also known as lipocalin-2/Lcn2, neutrophil gelatinase-associated lipocalin/NGAL) that can inhibit bacterial growth by sequestering iron in a ferric complex with enterobactin (Ent), the ubiquitous Escherichia coli siderophore.	Iron	195-199	lipocalin 2	Homo sapiens	96-138
31945748-2	2020	A marriage between OPE and Fe(II)-BPP systems is a strategy to obtain supramolecular luminescent ligands capable of metal coordination useful to produce novel spin-switchable hybrids with synergistic coupling between spin-state of Fe(II) and a physical property associated with the OPE skeleton, for example, electronic conductivity or luminescence.	Iron	27-37	spindlin 1	Homo sapiens	159-163
31945748-2	2020	A marriage between OPE and Fe(II)-BPP systems is a strategy to obtain supramolecular luminescent ligands capable of metal coordination useful to produce novel spin-switchable hybrids with synergistic coupling between spin-state of Fe(II) and a physical property associated with the OPE skeleton, for example, electronic conductivity or luminescence.	Iron	27-37	spindlin 1	Homo sapiens	217-221
31945748-2	2020	A marriage between OPE and Fe(II)-BPP systems is a strategy to obtain supramolecular luminescent ligands capable of metal coordination useful to produce novel spin-switchable hybrids with synergistic coupling between spin-state of Fe(II) and a physical property associated with the OPE skeleton, for example, electronic conductivity or luminescence.	Iron	27-33	spindlin 1	Homo sapiens	159-163
31945748-2	2020	A marriage between OPE and Fe(II)-BPP systems is a strategy to obtain supramolecular luminescent ligands capable of metal coordination useful to produce novel spin-switchable hybrids with synergistic coupling between spin-state of Fe(II) and a physical property associated with the OPE skeleton, for example, electronic conductivity or luminescence.	Iron	27-33	spindlin 1	Homo sapiens	217-221
31945748-6	2020	Complex [Fe(L1)]n(BF4)2n underwent thermal SCO centred at T1/2 = 275 K as well as photoinduced low-spin to high-spin transition with the existence of the metastable high-spin state up to 52 K. On the other hand, complex [Fe(L2)]n(BF4)2n, tethered with 2-ethylhexyloxy groups, showed gradual and half-complete SCO with 50% of the Fe(II)-centres permanently blocked in the high-spin state due to intermolecular steric interactions.	Iron	9-11	spindlin 1	Homo sapiens	99-103
31945748-6	2020	Complex [Fe(L1)]n(BF4)2n underwent thermal SCO centred at T1/2 = 275 K as well as photoinduced low-spin to high-spin transition with the existence of the metastable high-spin state up to 52 K. On the other hand, complex [Fe(L2)]n(BF4)2n, tethered with 2-ethylhexyloxy groups, showed gradual and half-complete SCO with 50% of the Fe(II)-centres permanently blocked in the high-spin state due to intermolecular steric interactions.	Iron	9-11	spindlin 1	Homo sapiens	112-116
31945748-6	2020	Complex [Fe(L1)]n(BF4)2n underwent thermal SCO centred at T1/2 = 275 K as well as photoinduced low-spin to high-spin transition with the existence of the metastable high-spin state up to 52 K. On the other hand, complex [Fe(L2)]n(BF4)2n, tethered with 2-ethylhexyloxy groups, showed gradual and half-complete SCO with 50% of the Fe(II)-centres permanently blocked in the high-spin state due to intermolecular steric interactions.	Iron	9-11	spindlin 1	Homo sapiens	112-116
31945748-6	2020	Complex [Fe(L1)]n(BF4)2n underwent thermal SCO centred at T1/2 = 275 K as well as photoinduced low-spin to high-spin transition with the existence of the metastable high-spin state up to 52 K. On the other hand, complex [Fe(L2)]n(BF4)2n, tethered with 2-ethylhexyloxy groups, showed gradual and half-complete SCO with 50% of the Fe(II)-centres permanently blocked in the high-spin state due to intermolecular steric interactions.	Iron	9-11	spindlin 1	Homo sapiens	112-116
32432042-3	2020	Here, we demonstrate that the alteration of iron homeostasis and the consequent increase of redox metabolism, mediated by the stable knock down of ferritin heavy chain (FtH), enhances the expression of CXCR4 in K562 erythroleukemia cells, thus promoting CXCL12-mediated motility.	Iron	44-48	C-X-C motif chemokine receptor 4	Homo sapiens	202-207
32432042-11	2020	The effects of FtH dysregulation on CXCR4/CXCL12-mediated K562 cell motility extend the meaning of iron homeostasis in the leukemia cell microenvironment.	Iron	99-103	C-X-C motif chemokine receptor 4	Homo sapiens	36-41
31967374-2	2020	Here we report the first N,N"-disubstituted 2,6-bis(pyrazol-3-yl)pyridines (3-bpp) that, against the common wisdom, induce a spin-crossover in otherwise high-spin iron(II) complexes by increasing the steric demand of a bulky substituent, an ortho-functionalized phenyl group.	Iron	163-171	spindlin 1	Homo sapiens	125-129
31967374-2	2020	Here we report the first N,N"-disubstituted 2,6-bis(pyrazol-3-yl)pyridines (3-bpp) that, against the common wisdom, induce a spin-crossover in otherwise high-spin iron(II) complexes by increasing the steric demand of a bulky substituent, an ortho-functionalized phenyl group.	Iron	163-171	spindlin 1	Homo sapiens	158-162
32064661-4	2020	More specifically, we provide molecular details on how conformational rearrangements of the iron-sulfur cluster domain and hinge regions of ABCE1 are linked to closure of its nucleotide-binding sites.	Iron	92-96	ATP binding cassette subfamily E member 1	Homo sapiens	140-145
32019729-6	2020	Finally, as loss of BPNT1 impairs expression of known genetic modifiers of iron-overload, we demonstrate that intestinal-epithelium specific loss of BPNT1 attenuates hepatic iron accumulation in mice with homozygous C282Y mutations in homeostatic iron regulator (HFEC282Y), the most common cause of hemochromatosis in humans.	Iron	75-79	3'(2'), 5'-bisphosphate nucleotidase 1	Mus musculus	20-25
32019729-6	2020	Finally, as loss of BPNT1 impairs expression of known genetic modifiers of iron-overload, we demonstrate that intestinal-epithelium specific loss of BPNT1 attenuates hepatic iron accumulation in mice with homozygous C282Y mutations in homeostatic iron regulator (HFEC282Y), the most common cause of hemochromatosis in humans.	Iron	174-178	3'(2'), 5'-bisphosphate nucleotidase 1	Mus musculus	149-154
32019729-6	2020	Finally, as loss of BPNT1 impairs expression of known genetic modifiers of iron-overload, we demonstrate that intestinal-epithelium specific loss of BPNT1 attenuates hepatic iron accumulation in mice with homozygous C282Y mutations in homeostatic iron regulator (HFEC282Y), the most common cause of hemochromatosis in humans.	Iron	174-178	3'(2'), 5'-bisphosphate nucleotidase 1	Mus musculus	149-154
32441176-13	2020	Positive correlations of urine beta2-MG, urine NGAL, and serum endocan levels with serum ferritin concentration indicated that iron deposition was associated with endothelial damage and renal injury.	Iron	127-131	endothelial cell specific molecule 1	Homo sapiens	63-70
32006009-8	2020	RESULTS: The Fe-Bean intervention had significant positive effects on hemoglobin, serum ferritin, and body iron stores but did not affect work efficiency.	Iron	107-111	brain expressed associated with NEDD4 1	Homo sapiens	16-20
32006009-11	2020	CONCLUSIONS: Increasing iron status during an iron-biofortified bean feeding trial improves work efficiency in iron-depleted, sedentary women.	Iron	24-28	brain expressed associated with NEDD4 1	Homo sapiens	64-68
32006009-11	2020	CONCLUSIONS: Increasing iron status during an iron-biofortified bean feeding trial improves work efficiency in iron-depleted, sedentary women.	Iron	46-50	brain expressed associated with NEDD4 1	Homo sapiens	64-68
32006009-11	2020	CONCLUSIONS: Increasing iron status during an iron-biofortified bean feeding trial improves work efficiency in iron-depleted, sedentary women.	Iron	46-50	brain expressed associated with NEDD4 1	Homo sapiens	64-68
32032665-2	2020	Frataxin loss leads to deleterious accumulations of redox-active, mitochondrial iron, and suppressed mitochondrial bioenergetics.	Iron	80-84	frataxin	Mus musculus	0-8
32186328-0	2020	Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.	Iron	86-90	hepatocyte growth factor	Rattus norvegicus	0-24
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	163-167	hepatocyte growth factor	Rattus norvegicus	16-40
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	163-167	hepatocyte growth factor	Rattus norvegicus	119-122
32186328-1	2020	In the light of hepatocyte growth factor (HGF) the inhibiting role on the expression of hepcidin, we hypothesized that HGF might be able to reduce cell and tissue iron by increasing ferroportin 1 (Fpn1) content and Fpn1-mediated iron release from cells and tissues.	Iron	229-233	hepatocyte growth factor	Rattus norvegicus	119-122
32186328-2	2020	The hypothesized ability of HGF to reduce iron might be one of the mechanisms associated with its neuroprotective action under the conditions of ischemia/reperfusion (I/R).	Iron	42-46	hepatocyte growth factor	Rattus norvegicus	28-31
32411666-10	2020	TPR profiles revealed a progressive change in the valency of Fe in its combined form to the zero valence-free metal.	Iron	61-63	translocated promoter region, nuclear basket protein	Homo sapiens	0-3
32276637-9	2020	Moreover, we found that GA-induced iron overload was activated by NMDAR-RASD1 signalling via DMT1 action in the brain.	Iron	35-39	RoBo-1	Rattus norvegicus	93-97
31855853-2	2020	In this work, three-dimensional (3D) mesoporous gamma-Fe2O3@carbon nanofiber (gamma-Fe2O3@CNF) mat has been synthesized by sol-gel based electrospinning and carbonization successfully.	Iron	48-59	NPHS1 adhesion molecule, nephrin	Homo sapiens	90-93
31855853-2	2020	In this work, three-dimensional (3D) mesoporous gamma-Fe2O3@carbon nanofiber (gamma-Fe2O3@CNF) mat has been synthesized by sol-gel based electrospinning and carbonization successfully.	Iron	78-89	NPHS1 adhesion molecule, nephrin	Homo sapiens	90-93
31855853-4	2020	The CNF network still maintained its pristine 3D nanostructure, which is not only demonstrated that fast ion transmission channel is important for Li+ and Na+ insertion/deinsertion, but also act as an electrical bridge between Li+/Na+ and gamma-Fe2O3 nanoparticles that decreases the impedance and buffers the volume expansion, resulting enhanced electrochemical cyclic and rate capability.	Iron	239-250	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-7
32273468-0	2020	Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	23-31
32273468-2	2020	We found that hepcidin, the master regulator of systemic iron homeostasis, is required for tissue repair in the mouse intestine after experimental damage.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	14-22
32195577-3	2020	Here, by combining iron porphyrin metal-organic frameworks (FePorMOF)-based peroxidase mimic with natural glucose oxidase (GOx), an intensive and persistent CL system is presented based on local tandem catalysis and surface diffusion of the nano/bio-enzymes (FePorMOF/GOx).	Iron	19-23	hydroxyacid oxidase 1	Homo sapiens	106-121
32195577-3	2020	Here, by combining iron porphyrin metal-organic frameworks (FePorMOF)-based peroxidase mimic with natural glucose oxidase (GOx), an intensive and persistent CL system is presented based on local tandem catalysis and surface diffusion of the nano/bio-enzymes (FePorMOF/GOx).	Iron	19-23	hydroxyacid oxidase 1	Homo sapiens	268-271
32260496-0	2020	Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics.	Iron	51-55	erythroferrone	Rattus norvegicus	13-27
32106786-2	2020	One possible pathway of particulate matter (PM)-induced toxicity is through iron (Fe), the most abundant metal in the atmosphere.	Iron	76-80	general transcription factor IIE subunit 1	Homo sapiens	82-84
32240658-9	2020	Iron accumulation in the bone marrow was associated with increased expression of genes for iron binding and transport proteins, including transferrin, transferrin receptor 1, ferroportin, and integrin alphaMbeta2.	Iron	0-4	transferrin	Mus musculus	138-149
22531912-1	2012	HFE, an MHC class Ib molecule that controls iron metabolism, can be directly targeted by cytotoxic TCR alphabeta T lymphocytes.	Iron	44-48	homeostatic iron regulator	Mus musculus	0-3
22113996-5	2012	A TAT-FXN fusion protein bound iron in vitro, transduced into mitochondria of FRDA deficient fibroblasts and reduced caspase-3 activation in response to an exogenous iron-oxidant stress.	Iron	31-35	caspase 3	Mus musculus	117-126
22113996-5	2012	A TAT-FXN fusion protein bound iron in vitro, transduced into mitochondria of FRDA deficient fibroblasts and reduced caspase-3 activation in response to an exogenous iron-oxidant stress.	Iron	166-170	caspase 3	Mus musculus	117-126
32240658-9	2020	Iron accumulation in the bone marrow was associated with increased expression of genes for iron binding and transport proteins, including transferrin, transferrin receptor 1, ferroportin, and integrin alphaMbeta2.	Iron	91-95	transferrin	Mus musculus	138-149
22244935-1	2012	Cell surface proteins Hfe, Tfr2, hemojuvelin and Tmprss6 play key roles in iron homeostasis.	Iron	75-79	homeostatic iron regulator	Mus musculus	22-25
31975050-4	2020	Yeast vma mutants exhibited nuclear localization of Aft1, which turns on the iron regulon in response to iron-sulfur cluster (ISC) deficiency.	Iron	77-81	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	52-56
22244935-1	2012	Cell surface proteins Hfe, Tfr2, hemojuvelin and Tmprss6 play key roles in iron homeostasis.	Iron	75-79	transferrin receptor 2	Mus musculus	27-31
22244935-1	2012	Cell surface proteins Hfe, Tfr2, hemojuvelin and Tmprss6 play key roles in iron homeostasis.	Iron	75-79	hemojuvelin BMP co-receptor	Mus musculus	33-44
22244935-9	2012	We demonstrate that lack of functional Tfr2 and Hfe allows for increased erythropoiesis even in the presence of high hepcidin expression, but the high levels of hepcidin levels significantly limit the availability of iron to the erythron, resulting in ineffective erythropoiesis.	Iron	217-221	hepcidin antimicrobial peptide	Mus musculus	161-169
32122995-0	2020	Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function.	Iron	33-37	CD4 antigen	Mus musculus	52-55
22262486-6	2012	Patients treated with IV iron were significantly less likely to develop platelets of &gt;=350,000 cells/uL (IRR 0.7, P = 0.013, Poisson regression) and had a decreased incidence of VTE.	Iron	25-29	insulin receptor related receptor	Homo sapiens	108-111
22086726-4	2012	Decreased expression of frataxin or the yeast frataxin orthologue, Yfh1p, is associated with decreased ISC assembly, mitochondrial iron accumulation, and increased oxidative stress, all of which contribute to mitochondrial dysfunction.	Iron	131-135	ferroxidase	Saccharomyces cerevisiae S288C	67-72
32122995-2	2020	However, the mechanisms by which iron controls CD4 T cell activation and expansion remain poorly understood.	Iron	33-37	CD4 antigen	Mus musculus	47-50
32122995-3	2020	In this study, we show that stimulation of CD4 T cells from C57BL/6 mice not only decreases total and labile iron levels but also leads to changes in the expression of iron homeostatic machinery.	Iron	109-113	CD4 antigen	Mus musculus	43-46
22038922-6	2012	Iron and BCL2-interacting mediator of cell death (BIM) protein were involved in LCN2-induced cell death sensitization, based on the studies using iron donor, chelator, siderophore, and short hairpin RNA (shRNA)-mediated knockdown of bim expression.	Iron	0-4	lipocalin 2	Homo sapiens	80-84
32122995-3	2020	In this study, we show that stimulation of CD4 T cells from C57BL/6 mice not only decreases total and labile iron levels but also leads to changes in the expression of iron homeostatic machinery.	Iron	168-172	CD4 antigen	Mus musculus	43-46
22038922-6	2012	Iron and BCL2-interacting mediator of cell death (BIM) protein were involved in LCN2-induced cell death sensitization, based on the studies using iron donor, chelator, siderophore, and short hairpin RNA (shRNA)-mediated knockdown of bim expression.	Iron	146-150	lipocalin 2	Homo sapiens	80-84
32122995-4	2020	Additionally, restraining iron availability in vitro severely inhibited CD4 T cell proliferation and cell cycle progression.	Iron	26-30	CD4 antigen	Mus musculus	72-75
32122995-5	2020	Although modulating cellular iron levels increased IL-2 production by activated T lymphocytes, CD25 expression and pSTAT5 levels were decreased, indicating that iron is necessary for IL-2R-mediated signaling.	Iron	29-33	interleukin 2 receptor, alpha chain	Mus musculus	183-188
32122995-5	2020	Although modulating cellular iron levels increased IL-2 production by activated T lymphocytes, CD25 expression and pSTAT5 levels were decreased, indicating that iron is necessary for IL-2R-mediated signaling.	Iron	161-165	interleukin 2 receptor, alpha chain	Mus musculus	183-188
22154532-9	2012	CONCLUSION: Taken together, our results indicate that vitamin A is involved in the regulation of IRP2, subsequently affecting iron metabolism gene expressions, such as Fn and TfR.	Iron	126-130	iron responsive element binding protein 2	Rattus norvegicus	97-101
32122995-7	2020	In all, we show that iron contributes to activation-induced T cell expansion by positively regulating IL-2R signaling and mitochondrial function.	Iron	21-25	interleukin 2 receptor, alpha chain	Mus musculus	102-107
32307375-2	2020	Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein, which is involved in iron trafficking and has chemostatic and bacteriostatic effects.	Iron	92-96	lipocalin 2	Homo sapiens	0-42
22271759-7	2012	Moreover, iron-mediated ferritin synthesis was evident in cells infected with an attenuated strain of poliovirus; when eIF4GI was cleaved, eIF2alpha was phosphorylated, and host protein synthesis was inhibited.	Iron	10-14	eukaryotic translation initiation factor 2A	Homo sapiens	139-148
32307375-2	2020	Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein, which is involved in iron trafficking and has chemostatic and bacteriostatic effects.	Iron	92-96	lipocalin 2	Homo sapiens	44-48
32159166-5	2020	This translates into geometrical distortions of the first coordination sphere of the iron atom that seem to correlate with the decreased spin conversion.	Iron	85-89	spindlin 1	Homo sapiens	137-141
22400942-0	2012	Structure of iron to 1 Gbar and 40, 000 K. First-principles calculations show that compression-induced electronic transitions produce a rich phase diagram featuring reentrant stability of the fcc phase with an extremum on the fcc to hcp boundary at 23 Mbar and 19 000 K, conditions similar to those expected at the center of super-Earth exoplanets.	Iron	13-17	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	233-236
22400954-0	2012	Spin coupling and orbital angular momentum quenching in free iron clusters.	Iron	61-65	spindlin 1	Homo sapiens	0-4
31839625-10	2020	Dex regulates iron metabolism by regulating iron importers and exporters through JNK/Sp1 and Stat4/Sp1 signaling.	Iron	14-18	signal transducer and activator of transcription 4	Homo sapiens	93-98
32014824-0	2020	KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne?	Iron	70-81	KRAS proto-oncogene, GTPase	Rattus norvegicus	0-4
22095982-1	2012	OBJECTIVE: We recently reported that lowering of macrophage free intracellular iron increases expression of cholesterol efflux transporters ABCA1 and ABCG1 by reducing generation of reactive oxygen species.	Iron	79-83	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	140-145
22095982-2	2012	In this study, we explored whether reducing macrophage intracellular iron levels via pharmacological suppression of hepcidin can increase macrophage-specific expression of cholesterol efflux transporters and reduce atherosclerosis.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	116-124
22095982-9	2012	All preceding LDN-induced effects on cholesterol efflux were reversed by exogenous hepcidin administration, suggesting modulation of intracellular iron levels within macrophages as the mechanism by which LDN triggers these effects.	Iron	147-151	hepcidin antimicrobial peptide	Mus musculus	83-91
22101253-4	2012	More recently, the roles of these two human ferredoxins in iron-sulfur cluster assembly were assessed, and it was concluded that FDX1 was important solely for its interaction with p450 enzymes to synthesize mitochondrial steroid precursors, whereas FDX2 was used for synthesis of iron-sulfur clusters, but not steroidogenesis.	Iron	59-63	ferredoxin 1	Homo sapiens	129-133
22101253-4	2012	More recently, the roles of these two human ferredoxins in iron-sulfur cluster assembly were assessed, and it was concluded that FDX1 was important solely for its interaction with p450 enzymes to synthesize mitochondrial steroid precursors, whereas FDX2 was used for synthesis of iron-sulfur clusters, but not steroidogenesis.	Iron	280-284	ferredoxin 1	Homo sapiens	129-133
22101253-6	2012	We concluded that both FDX1 and FDX2 were important in iron-sulfur cluster biogenesis.	Iron	55-59	ferredoxin 1	Homo sapiens	23-27
22101253-7	2012	Loss of FDX1 activity disrupted activity of iron-sulfur cluster enzymes and cellular iron homeostasis, causing mitochondrial iron overload and cytosolic iron depletion.	Iron	44-48	ferredoxin 1	Homo sapiens	8-12
22101253-7	2012	Loss of FDX1 activity disrupted activity of iron-sulfur cluster enzymes and cellular iron homeostasis, causing mitochondrial iron overload and cytosolic iron depletion.	Iron	85-89	ferredoxin 1	Homo sapiens	8-12
22101253-7	2012	Loss of FDX1 activity disrupted activity of iron-sulfur cluster enzymes and cellular iron homeostasis, causing mitochondrial iron overload and cytosolic iron depletion.	Iron	85-89	ferredoxin 1	Homo sapiens	8-12
22101253-7	2012	Loss of FDX1 activity disrupted activity of iron-sulfur cluster enzymes and cellular iron homeostasis, causing mitochondrial iron overload and cytosolic iron depletion.	Iron	85-89	ferredoxin 1	Homo sapiens	8-12
32014824-0	2020	KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne?	Iron	70-81	KRAS proto-oncogene, GTPase	Rattus norvegicus	40-44
22101253-9	2012	Our studies suggest that interference with any of the three related genes, FDX1, FDX2 or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis.	Iron	104-108	ferredoxin 1	Homo sapiens	75-79
22101253-9	2012	Our studies suggest that interference with any of the three related genes, FDX1, FDX2 or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis.	Iron	187-191	ferredoxin 1	Homo sapiens	75-79
31393024-3	2020	Six-transmembrane epithelial antigen of the prostate 3 (Steap3), a key regulator of iron uptake, was reported to be involved in immunity and apoptotic processes in various cell types.	Iron	84-88	STEAP family member 3	Mus musculus	56-62
21826460-11	2012	Overall, our data suggest that ZIP5, ZIP6, ZIP7, and ZIP10 are regulated by iron, indicating that they may play a role in hepatic iron/metal homeostasis during iron deficiency and overload.	Iron	76-80	solute carrier family 39 member 6	Rattus norvegicus	37-41
21826460-11	2012	Overall, our data suggest that ZIP5, ZIP6, ZIP7, and ZIP10 are regulated by iron, indicating that they may play a role in hepatic iron/metal homeostasis during iron deficiency and overload.	Iron	130-134	solute carrier family 39 member 6	Rattus norvegicus	37-41
31835128-9	2020	Gene (mRNA) expression levels of duodenal ferroportin and duodenal cytochrome b (proteins involved in iron absorption) were decreased, while that of divalent metal transporter-1 (DMT-1) was unchanged.	Iron	102-106	cytochrome b reductase 1	Homo sapiens	58-79
21767448-8	2012	Mean n-3 PUFA intake represented 0 7-1 1 % FE.	Iron	43-45	pumilio RNA binding family member 3	Homo sapiens	9-13
32079304-0	2020	Iron Overload Mimicking Conditions Skews Bone Marrow Dendritic Cells Differentiation into MHCIIlowCD11c+CD11b+F4/80+ Cells.	Iron	0-4	integrin subunit alpha M	Homo sapiens	104-109
31896574-0	2020	The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.	Iron	18-22	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	96-100
22340148-3	2012	RESULTS: Significant correlations were found between GAF scores and energy (kilocalories), carbohydrates, fibre, total fat, linoleic acid, riboflavin, niacin, folate, vitamin B6, vitamin B12, pantothenic acid, calcium, phosphorus, potassium, and iron (all P values &lt; 0.05), as well as magnesium (r = 0.41, P &lt; 0.001) and zinc (r = 0.35, P &lt; 0.001).	Iron	246-250	fibroblast growth factor 9	Homo sapiens	53-56
21757452-1	2012	BACKGROUNDS AND AIMS: Hepcidin is an antimicrobial peptide and the central regulator of iron metabolism.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	22-30
31896574-3	2020	Here, we report that MMT1 and MMT2 expression is transcriptionally regulated by two pathways: the low-iron sensing transcription factor Aft1 and the oxidant-sensing transcription factor Yap1.	Iron	102-106	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	136-140
31761321-0	2020	Local hepcidin increased intracellular iron overload via the degradation of ferroportin in the kidney.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	6-14
31761321-1	2020	BACKGROUND: Hepcidin is a key regulator of iron homeostasis.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	12-20
21993681-1	2012	Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	38-46
31761321-2	2020	Some studies showed that exogenous hepcidin decreased the expression of divalent metal transporter (DMT1) rather than ferroportin(FPN1) to regulate renal iron metabolism.	Iron	154-158	hepcidin antimicrobial peptide	Mus musculus	35-43
21993681-1	2012	Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin.	Iron	80-84	transferrin	Mus musculus	161-172
31761321-3	2020	This study explored the effects of hepcidin synthesized by the kidney and its mechanism of iron regulation.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	35-43
21993681-1	2012	Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin.	Iron	111-115	hepcidin antimicrobial peptide	Mus musculus	38-46
21993681-1	2012	Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin.	Iron	111-115	transferrin	Mus musculus	161-172
21993681-1	2012	Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin.	Iron	111-115	hepcidin antimicrobial peptide	Mus musculus	38-46
31898885-8	2020	In addition, small multivalent cations (e.g., Ca2+, Fe2+, and Fe3+) are distinguishably measurable over monovalent cations (e.g., Na+ and K+) with the pNIPAm-co-AAc nanogels.	Iron	52-56	glycine-N-acyltransferase	Homo sapiens	161-164
21993681-1	2012	Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin.	Iron	111-115	transferrin	Mus musculus	161-172
21993681-2	2012	Mice deficient in transferrin (Tf(hpx/hpx)) and hemojuvelin (Hjv(-/-)), a gene mutated in juvenile hemochromatosis, a disease of hepcidin deficiency and iron overload, were generated.	Iron	153-157	hemojuvelin BMP co-receptor	Mus musculus	48-59
21993681-2	2012	Mice deficient in transferrin (Tf(hpx/hpx)) and hemojuvelin (Hjv(-/-)), a gene mutated in juvenile hemochromatosis, a disease of hepcidin deficiency and iron overload, were generated.	Iron	153-157	hemojuvelin BMP co-receptor	Mus musculus	61-69
21838701-1	2012	Hepcidin, a 25 amino acid peptide hormone containing a complex network of four disulfide bonds is the hormone regulator of iron homeostasis.	Iron	123-127	hepcidin antimicrobial peptide	Mus musculus	0-8
31898885-8	2020	In addition, small multivalent cations (e.g., Ca2+, Fe2+, and Fe3+) are distinguishably measurable over monovalent cations (e.g., Na+ and K+) with the pNIPAm-co-AAc nanogels.	Iron	62-66	glycine-N-acyltransferase	Homo sapiens	161-164
31733261-0	2020	A distinctive sequence motif in the fourth transmembrane domain confers ZIP13 iron function in Drosophila melanogaster.	Iron	78-82	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	72-77
22128145-0	2012	Deletion of HIF-2alpha in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	91-99
22128145-3	2012	A deficit in hepcidin results in intestinal iron hyperabsorption; however, the local effectors mediating the up-regulation of iron absorption genes are unknown.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	13-21
22128145-5	2012	We generated Hepc(-/-) mice (a murine model of hemochromatosis) lacking HIF-2 in the intestine and showed that duodenal HIF-2 was essential for the up-regulation of genes involved in intestinal iron import and the consequent iron accumulation in the liver and pancreas.	Iron	194-198	hepcidin antimicrobial peptide	Mus musculus	13-17
31733261-4	2020	Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway.	Iron	103-107	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	71-76
31733261-4	2020	Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway.	Iron	103-107	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	78-84
22132821-7	2012	We show, for the first time, that the rate determining barrier for aromatic hydroxylation is proportional to the strength of the O-H bond in the corresponding iron(IV)-hydroxo complex, i.e., BDE(OH), hence this thermochemical property of the oxidant drives the reaction and represents the axial ligand effect.	Iron	159-163	homeobox D13	Homo sapiens	191-194
31733261-4	2020	Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway.	Iron	149-153	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	71-76
31733261-4	2020	Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway.	Iron	149-153	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	78-84
31733261-8	2020	Swapping D/H position of this DNXXH sequence in dZIP13 resulted in loss of iron activity; normal dZIP13 could not complement dZIP7 loss, but swapping the two relative amino acid positions D and H in dZIP13 was sufficient to make it functionally analogous to its close homologue dZIP7.	Iron	75-79	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	48-54
31812496-0	2020	Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	98-106
26592881-12	2012	We quickly recover the performance of the original parameter set and then significantly improve it to reproduce the geometries and spin state energy differences of an extended series of complexes with RMSD errors in Fe-N and N-N distances reduced from 0.06 A to 0.03 A and spin state energy difference RMSDs reduced from 1.5 kcal mol(-1) to 0.2 kcal mol(-1).	Iron	216-220	spindlin 1	Homo sapiens	131-135
22023931-12	2012	This study provided evidence in support of the calcium deficiency hypothesis leading to urinary phosphate wasting and rickets and identified glomerular filtration rate and iron status as possible modulators of FGF23 metabolic pathways.	Iron	172-176	fibroblast growth factor 23	Homo sapiens	210-215
31812496-4	2020	Mice deficient in hepcidin (the central regulator of systemic iron homeostasis) (Hamp1-/- mice) accumulate iron in the liver in vivo.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	18-26
31812496-4	2020	Mice deficient in hepcidin (the central regulator of systemic iron homeostasis) (Hamp1-/- mice) accumulate iron in the liver in vivo.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	81-86
31812496-4	2020	Mice deficient in hepcidin (the central regulator of systemic iron homeostasis) (Hamp1-/- mice) accumulate iron in the liver in vivo.	Iron	107-111	hepcidin antimicrobial peptide	Mus musculus	18-26
31812496-4	2020	Mice deficient in hepcidin (the central regulator of systemic iron homeostasis) (Hamp1-/- mice) accumulate iron in the liver in vivo.	Iron	107-111	hepcidin antimicrobial peptide	Mus musculus	81-86
22201778-1	2012	FES and FES-related (FER) comprise a unique subfamily of protein-tyrosine kinases (PTKs) that signal downstream of several classes of receptors involved in regulating hematopoietic cell development, survival, migration, and inflammatory mediator release.	Iron	0-3	fer (fms/fps related) protein kinase	Mus musculus	21-24
31812496-9	2020	Incubation of the Hamp1-/- hepatocytes with an iron chelator attenuated these effects.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	18-23
31772326-0	2020	The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma.	Iron	4-8	lipocalin 2	Homo sapiens	17-28
22536021-5	2012	RESULTS: In vitro and in vivo overexpression of FTH1 significantly increased the transverse relaxivity (R(2)), which could be enhanced by iron supplementation.	Iron	138-142	ferritin heavy polypeptide 1	Mus musculus	48-52
31772326-0	2020	The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma.	Iron	4-8	lipocalin 2	Homo sapiens	30-35
22536021-9	2012	CONCLUSION: To maximize R(2) and minimize the potential adverse effects, supplementation of iron at appropriate dose is recommended during the application of FTH1 as a reporter gene in the monitoring of NPC by MRI.	Iron	92-96	ferritin heavy polypeptide 1	Mus musculus	158-162
31772326-2	2020	Since LCN-2 was recently identified as a novel iron transporter, we explored its iron load as a decisive factor in conferring its biological function.	Iron	47-51	lipocalin 2	Homo sapiens	6-11
31772326-2	2020	Since LCN-2 was recently identified as a novel iron transporter, we explored its iron load as a decisive factor in conferring its biological function.	Iron	81-85	lipocalin 2	Homo sapiens	6-11
22894113-1	2012	FeOx-CeO2 mixed oxides with increasing Fe/(Ce+Fe) atomic ratio (1-20 mol%) were prepared by sol-gel method and characterized by X-ray powder diffraction (XRD), Brunauer-Emmett-Teller (BET) and Hydrogen temperature-programmed reduction (H2-TPR) techniques.	Iron	0-2	translocated promoter region, nuclear basket protein	Homo sapiens	239-242
22894113-5	2012	TPR analysis revealed that Fe introduction into ceria strongly modified the textual and structural properties, which influenced the oxygen handling properties.	Iron	27-29	translocated promoter region, nuclear basket protein	Homo sapiens	0-3
31772326-4	2020	We measured LCN-2-bound iron by atomic absorption spectrometry from patient-derived samples and applied functional assays by using ccRCC cell lines, primary cells, and 3D tumour spheroids to verify the role of the LCN-2 iron load in tumour progression.	Iron	24-28	lipocalin 2	Homo sapiens	12-17
31772326-6	2020	LCN-2 protein was found overexpressed in tumour compared with adjacent healthy tissue, whereby LCN-2 was iron loaded.	Iron	105-109	lipocalin 2	Homo sapiens	0-5
21808735-1	2012	Neuroferritinopathy is a neurodegenerative disease which demonstrates brain iron accumulation caused by the mutations in the ferritin light chain gene.	Iron	76-80	ferritin light chain	Homo sapiens	125-145
31772326-6	2020	LCN-2 protein was found overexpressed in tumour compared with adjacent healthy tissue, whereby LCN-2 was iron loaded.	Iron	105-109	lipocalin 2	Homo sapiens	95-100
31772326-7	2020	In vitro, the iron load determines the biological function of LCN-2.	Iron	14-18	lipocalin 2	Homo sapiens	62-67
31772326-8	2020	Iron-loaded LCN-2 showed pro-tumour functions, whereas iron-free LCN-2 produced adverse effects.	Iron	0-4	lipocalin 2	Homo sapiens	12-17
22234997-0	2012	Localized iron supply triggers lateral root elongation in Arabidopsis by altering the AUX1-mediated auxin distribution.	Iron	10-14	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	86-90
31772326-8	2020	Iron-loaded LCN-2 showed pro-tumour functions, whereas iron-free LCN-2 produced adverse effects.	Iron	55-59	lipocalin 2	Homo sapiens	65-70
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	7-9	iron-regulated transporter 1	Arabidopsis thaliana	34-61
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	7-9	iron-regulated transporter 1	Arabidopsis thaliana	63-67
31772326-10	2020	LCN-2 donates iron to cells to promote migration and matrix adhesion.	Iron	14-18	lipocalin 2	Homo sapiens	0-5
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	7-9	iron-regulated transporter 1	Arabidopsis thaliana	141-145
31772326-11	2020	Since the iron load of LCN-2 determines its pro-tumour characteristics, targeting either its iron load or its receptor interaction might represent new therapeutic options.	Iron	10-14	lipocalin 2	Homo sapiens	23-28
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	171-173	iron-regulated transporter 1	Arabidopsis thaliana	34-61
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	171-173	iron-regulated transporter 1	Arabidopsis thaliana	63-67
31772326-11	2020	Since the iron load of LCN-2 determines its pro-tumour characteristics, targeting either its iron load or its receptor interaction might represent new therapeutic options.	Iron	93-97	lipocalin 2	Homo sapiens	23-28
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	171-173	iron-regulated transporter 1	Arabidopsis thaliana	141-145
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	171-173	iron-regulated transporter 1	Arabidopsis thaliana	34-61
31907996-3	2020	However, the role of Mdm2 in iron homeostasis is not certain.	Iron	29-33	MDM2 proto-oncogene	Homo sapiens	21-25
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	171-173	iron-regulated transporter 1	Arabidopsis thaliana	63-67
22234997-4	2012	In the Fe uptake-defective mutant iron-regulated transporter1 (irt1), lateral root development was severely repressed, but a requirement for IRT1 could be circumvented by Fe application to shoots, indicating that symplastic Fe triggered the local elongation of lateral roots.	Iron	171-173	iron-regulated transporter 1	Arabidopsis thaliana	141-145
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	67-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	67-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	135-139
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	67-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	209-213
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	135-139
31907996-4	2020	Here, we showed that Mdm2 expression was increased by iron depletion but decreased by iron repletion.	Iron	54-58	MDM2 proto-oncogene	Homo sapiens	21-25
31907996-4	2020	Here, we showed that Mdm2 expression was increased by iron depletion but decreased by iron repletion.	Iron	86-90	MDM2 proto-oncogene	Homo sapiens	21-25
31907996-5	2020	We also showed that Iron Regulatory Protein 2 (IRP2) mediated iron-regulated Mdm2 expression.	Iron	62-66	MDM2 proto-oncogene	Homo sapiens	77-81
31652009-4	2020	We conducted a prospective open label pilot clinical trial of oral iron replacement over 12 months in ADHR patients to test the hypothesis that oral iron administration would normalize FGF23 concentrations.	Iron	149-153	fibroblast growth factor 23	Homo sapiens	185-190
23236349-6	2012	When applied to colorectal cancer, we identified a missense polymorphism in iron-absorption gene CYBRD1 that associated with disease in individuals of English, but not Scottish, ancestry.	Iron	76-80	cytochrome b reductase 1	Homo sapiens	97-103
22792339-1	2012	Hepcidin, a liver-derived iron regulatory protein, plays a crucial role in iron metabolism.	Iron	26-30	hepcidin antimicrobial peptide	Mus musculus	0-8
22792339-15	2012	Thus, estrogen is involved in hepcidin expression via a GPR30-BMP6-dependent mechanism, providing new insight into the role of estrogen in iron metabolism.	Iron	139-143	hepcidin antimicrobial peptide	Mus musculus	30-38
22792339-15	2012	Thus, estrogen is involved in hepcidin expression via a GPR30-BMP6-dependent mechanism, providing new insight into the role of estrogen in iron metabolism.	Iron	139-143	G protein-coupled estrogen receptor 1	Mus musculus	56-61
31652009-15	2020	Oral iron repletion normalized FGF23 and phosphorus in symptomatic, iron-deficient ADHR subjects.	Iron	5-9	fibroblast growth factor 23	Homo sapiens	31-36
31339576-0	2020	Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype.	Iron	48-52	transferrin	Mus musculus	0-11
22675442-0	2012	Tumor necrosis factor alpha inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	79-87
22675442-1	2012	BACKGROUND: Abnormal expression of the liver peptide hormone hepcidin, a key regulator of iron homeostasis, contributes to the pathogenesis of anemia in conditions such as inflammatory bowel disease (IBD).	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	61-69
22675442-6	2012	Hepcidin expression progressively decreased with time during DSS colitis, correlating with changes in systemic iron distribution.	Iron	111-115	hepcidin antimicrobial peptide	Mus musculus	0-8
31339576-0	2020	Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype.	Iron	48-52	ferritin heavy polypeptide 1	Mus musculus	16-26
31339576-5	2020	In this study, we used a mouse model expressing a mutant form of the iron homeostatic regulator protein HFE, (Hfe H63D), the most common gene variant in Caucasians, to determine impact of the mutation on brain iron uptake.	Iron	69-73	homeostatic iron regulator	Mus musculus	104-107
31339576-5	2020	In this study, we used a mouse model expressing a mutant form of the iron homeostatic regulator protein HFE, (Hfe H63D), the most common gene variant in Caucasians, to determine impact of the mutation on brain iron uptake.	Iron	69-73	homeostatic iron regulator	Mus musculus	110-113
22629388-0	2012	Effect of iron overload and iron deficiency on liver hemojuvelin protein.	Iron	10-14	hemojuvelin BMP co-receptor	Mus musculus	53-64
22629388-2	2012	The purpose of this study was to determine Hjv protein levels in mice and rats subjected to iron overload and iron deficiency.	Iron	92-96	hemojuvelin BMP co-receptor	Mus musculus	43-46
31339576-5	2020	In this study, we used a mouse model expressing a mutant form of the iron homeostatic regulator protein HFE, (Hfe H63D), the most common gene variant in Caucasians, to determine impact of the mutation on brain iron uptake.	Iron	210-214	homeostatic iron regulator	Mus musculus	104-107
22629388-12	2012	Liver Hamp mRNA, Bmp6 mRNA and Id1 mRNA displayed the expected response to iron overload and iron deficiency.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	6-10
31339576-6	2020	Iron uptake was assessed using 59 Fe bound to either transferrin or H-ferritin as the iron carrier proteins.	Iron	0-4	transferrin	Mus musculus	53-64
22629388-12	2012	Liver Hamp mRNA, Bmp6 mRNA and Id1 mRNA displayed the expected response to iron overload and iron deficiency.	Iron	75-79	inhibitor of DNA binding 1, HLH protein	Mus musculus	31-34
31339576-6	2020	Iron uptake was assessed using 59 Fe bound to either transferrin or H-ferritin as the iron carrier proteins.	Iron	0-4	ferritin heavy polypeptide 1	Mus musculus	68-78
31339576-6	2020	Iron uptake was assessed using 59 Fe bound to either transferrin or H-ferritin as the iron carrier proteins.	Iron	86-90	ferritin heavy polypeptide 1	Mus musculus	68-78
31339576-8	2020	Moreover, we introduce H-ferritin as a key protein in brain iron transport during development and identify a sex and genotype effect demonstrating female mutant mice take up more iron by transferrin, whereas male mutant mice take up more iron from H-ferritin at PND22.	Iron	60-64	ferritin heavy polypeptide 1	Mus musculus	23-33
31339576-8	2020	Moreover, we introduce H-ferritin as a key protein in brain iron transport during development and identify a sex and genotype effect demonstrating female mutant mice take up more iron by transferrin, whereas male mutant mice take up more iron from H-ferritin at PND22.	Iron	179-183	ferritin heavy polypeptide 1	Mus musculus	23-33
22649292-5	2012	The concentrations of iron and manganese in the tap water samples were higher than the standard limits, which were obtained from one and three of the studied locations, respectively.	Iron	22-26	nuclear RNA export factor 1	Homo sapiens	48-51
31339576-8	2020	Moreover, we introduce H-ferritin as a key protein in brain iron transport during development and identify a sex and genotype effect demonstrating female mutant mice take up more iron by transferrin, whereas male mutant mice take up more iron from H-ferritin at PND22.	Iron	179-183	transferrin	Mus musculus	187-198
31339576-8	2020	Moreover, we introduce H-ferritin as a key protein in brain iron transport during development and identify a sex and genotype effect demonstrating female mutant mice take up more iron by transferrin, whereas male mutant mice take up more iron from H-ferritin at PND22.	Iron	179-183	ferritin heavy polypeptide 1	Mus musculus	23-33
21865063-5	2011	GDF-15 levels were significantly higher in splenectomized compared to non-splenectomized patients and correlated with anemia, markers of iron overload, and a pre-defined clinical severity score.	Iron	137-141	growth differentiation factor 15	Homo sapiens	0-6
31339576-8	2020	Moreover, we introduce H-ferritin as a key protein in brain iron transport during development and identify a sex and genotype effect demonstrating female mutant mice take up more iron by transferrin, whereas male mutant mice take up more iron from H-ferritin at PND22.	Iron	179-183	transferrin	Mus musculus	187-198
31755170-3	2020	In this study, the localizations of hepcidin, ferroportin, and hephaestin, which are known to be involved in iron efflux, were immunohistochemically examined in autopsied human brains.	Iron	109-113	hephaestin	Homo sapiens	63-73
22084434-1	2011	Hepcidin is one of the regulators of iron metabolism.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	0-8
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	65-69	protein kinase MEC1	Saccharomyces cerevisiae S288C	19-23
22152479-4	2011	Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity and promote its degradation.	Iron	168-172	protein kinase MEC1	Saccharomyces cerevisiae S288C	19-23
31726340-6	2020	A stable dispersion of PAM-MAG was prepared with 0.3 wt% of PAM and 0.1 g/L as Fe of magnetite.	Iron	79-81	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	23-26
21931161-4	2011	Here, we present evidence supporting the model that beta" is required for iron loading and Tyr( ) formation in beta in vivo via a pathway that is likely dependent on the cytosolic monothiol glutaredoxins Grx3/Grx4 and the Fe-S cluster protein Dre2.	Iron	74-78	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	204-208
32012946-5	2020	Our data suggest that there are alterations in specific metal binding proteins, for zinc, copper and iron all being modulated in the ZnT3 KO mice compared to wild-type (WT).	Iron	101-105	solute carrier family 30 (zinc transporter), member 3	Mus musculus	133-137
21954453-9	2011	Hepcidin, a major regulator of hepatic iron trafficking, was elevated in piglets fed formula relative to breast-fed piglets (P&lt;0.05).	Iron	39-43	hepcidin antimicrobial peptide	Sus scrofa	0-8
21359624-7	2011	CONCLUSION: Modulation of Hif-2alpha predominates over hepcidin in the regulation of intestinal iron absorption during short hypoxic duration.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	55-63
32055716-4	2020	We further verified the authenticity of the ferric reductase activity of 101F6 using nitroso-PSAP as a Fe2+-specific colorimetric chelator.	Iron	103-107	prosaposin	Homo sapiens	93-97
21859731-6	2011	RESULTS: SMAD1/5/8 phosphorylation and in parallel hepcidin mRNA expression were increased in anemia of chronic disease but significantly down-regulated in anemia of chronic disease with concomitant iron deficiency, either on the basis of phlebotomy or dietary iron restriction.	Iron	199-203	SMAD family member 1	Rattus norvegicus	9-16
21859731-8	2011	Reduced SMAD1/5/8 activity in association with phlebotomy was paralleled by increased expression of the inhibitory factor, SMAD7, dietary iron restriction appeared to impair hepcidin transactivating SMAD pathways via reduction of membrane bound hemojuvelin expression.	Iron	138-142	SMAD family member 1	Rattus norvegicus	8-15
31941883-0	2020	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.	Iron	42-46	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	56-62
21873542-17	2011	Dietary Fe resulted in linear increases (P &lt; 0.01) in ADG from d 21 to 35 and d 0 to 35.	Iron	8-10	ADG	Sus scrofa	57-60
31941883-2	2020	Here we show that mice lacking iron-regulatory protein 2 (Irp2), a regulator of cellular iron homeostasis, develop diabetes.	Iron	31-35	iron responsive element binding protein 2	Mus musculus	58-62
22045566-8	2011	Further modifications to increase resistance to proteolysis and oral bioavailability yielded minihepcidins that, after parenteral or oral administration to mice, lowered serum iron levels comparably to those after parenteral native hepcidin.	Iron	176-180	hepcidin antimicrobial peptide	Mus musculus	97-105
31744884-3	2020	Dp44mT and DpC up-regulated NDRG1 by an iron-dependent mechanism and decreased c-Met levels, c-Met phosphorylation, and phosphorylation of its downstream effector, GRB2-associated binding protein 1 (GAB1).	Iron	40-44	N-myc downstream regulated 1	Homo sapiens	28-33
21917924-6	2011	CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of either CCC1 or YAP5 resulted in high iron sensitivity.	Iron	17-21	Ccc1p	Saccharomyces cerevisiae S288C	0-4
31677393-4	2020	Upon intratumoral injection and NIR laser exposure, such GA-Fe show rapid temperature increase, which would simultaneously increase the catalytic efficiencies of GA-Fe and GOx.	Iron	60-62	hydroxyacid oxidase 1	Homo sapiens	172-175
21884746-4	2011	Computer analysis showed IRP1-3 as a dimeric membrane protein potentially involved in iron uptake.	Iron	86-90	aconitase 1	Mus musculus	25-29
21884746-9	2011	Expression of IRP1-3 was found conserved among clinical isolates of B. pertussis and positively regulated by iron starvation in these strains.	Iron	109-113	aconitase 1	Mus musculus	14-18
31657968-3	2020	The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis.	Iron	24-28	CD68 molecule	Homo sapiens	68-72
22019085-1	2011	The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma.	Iron	4-8	Solute carrier family 40 protein	Caenorhabditis elegans	18-29
22019085-1	2011	The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma.	Iron	4-8	Solute carrier family 40 protein	Caenorhabditis elegans	31-34
22019085-1	2011	The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma.	Iron	61-65	Solute carrier family 40 protein	Caenorhabditis elegans	18-29
31657968-3	2020	The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis.	Iron	24-28	integrin subunit alpha M	Homo sapiens	78-83
22019085-1	2011	The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma.	Iron	61-65	Solute carrier family 40 protein	Caenorhabditis elegans	31-34
22019085-2	2011	Systemic iron homeostasis in vertebrates is regulated by the hepcidin-mediated internalization of Fpn.	Iron	9-13	Solute carrier family 40 protein	Caenorhabditis elegans	98-101
33612641-2	2020	Iron is one of important essential trace elements that serves as co-factor for thyroid peroxidase (TPO).	Iron	0-4	thyroid peroxidase	Homo sapiens	79-97
22019085-3	2011	Here, we demonstrate a second route for Fpn internalization; when cytosolic iron levels are low, Fpn is internalized in a hepcidin-independent manner dependent upon the E3 ubiquitin ligase Nedd4-2 and the Nedd4-2 binding protein Nfdip-1.	Iron	76-80	Solute carrier family 40 protein	Caenorhabditis elegans	40-43
22019085-3	2011	Here, we demonstrate a second route for Fpn internalization; when cytosolic iron levels are low, Fpn is internalized in a hepcidin-independent manner dependent upon the E3 ubiquitin ligase Nedd4-2 and the Nedd4-2 binding protein Nfdip-1.	Iron	76-80	Solute carrier family 40 protein	Caenorhabditis elegans	97-100
22019085-3	2011	Here, we demonstrate a second route for Fpn internalization; when cytosolic iron levels are low, Fpn is internalized in a hepcidin-independent manner dependent upon the E3 ubiquitin ligase Nedd4-2 and the Nedd4-2 binding protein Nfdip-1.	Iron	76-80	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	189-196
22019085-4	2011	Retention of cell-surface Fpn through reductions in Nedd4-2 results in cell death through depletion of cytosolic iron.	Iron	113-117	Solute carrier family 40 protein	Caenorhabditis elegans	26-29
22019085-6	2011	C. elegans lacks hepcidin genes, and C. elegans Fpn expressed in mammalian cells is not internalized by hepcidin but is internalized in response to iron deprivation in a Nedd4-2-dependent manner, supporting the hypothesis that Nedd4-2-induced internalization of Fpn is evolutionarily conserved.	Iron	148-152	Solute carrier family 40 protein	Caenorhabditis elegans	48-51
22019085-6	2011	C. elegans lacks hepcidin genes, and C. elegans Fpn expressed in mammalian cells is not internalized by hepcidin but is internalized in response to iron deprivation in a Nedd4-2-dependent manner, supporting the hypothesis that Nedd4-2-induced internalization of Fpn is evolutionarily conserved.	Iron	148-152	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	170-177
33612641-2	2020	Iron is one of important essential trace elements that serves as co-factor for thyroid peroxidase (TPO).	Iron	0-4	thyroid peroxidase	Homo sapiens	99-102
31631429-1	2020	Small molecule biomimetics inspired by the active site of the [FeFe]-hydrogenase enzymes have shown promising electrocatalytic activity for hydrogen (H2 ) generation.	Iron	63-67	relaxin 2	Homo sapiens	140-152
22055506-3	2011	We have identified the iron-dependent prolyl hydroxylases (PHDs) and asparaginyl hydroxylase (FIH1) that modify hypoxia-inducible factor alpha (HIFalpha) as targets of PCBP1.	Iron	23-27	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	94-98
21817060-1	2011	The HFE protein plays a crucial role in the control of cellular iron homeostasis.	Iron	64-68	homeostatic iron regulator	Mus musculus	4-7
21817060-2	2011	Steatosis is commonly observed in HFE-related iron-overload disorders, and current evidence suggests a causal link between iron and steatosis.	Iron	46-50	homeostatic iron regulator	Mus musculus	34-37
31679114-0	2020	Association between vitamin D receptor (FokI) genetic variant rs2228570 and iron profile in hemodialysis patients.	Iron	76-80	vitamin D receptor	Homo sapiens	20-38
21817060-2	2011	Steatosis is commonly observed in HFE-related iron-overload disorders, and current evidence suggests a causal link between iron and steatosis.	Iron	123-127	homeostatic iron regulator	Mus musculus	34-37
21817060-9	2011	In conclusion, our results demonstrate that Hfe(-/-) mice show defective hepatic-intestinal iron and lipid signaling, which predispose them toward diet-induced hepatic lipotoxicity, accompanied by an accelerated progression of injury to fibrosis.	Iron	92-96	homeostatic iron regulator	Mus musculus	44-47
31679114-2	2020	This study investigated the association between vitamin D receptor (VDR) genetic variant (FokI) rs2228570 with iron indices (serum iron, transferrin, transferrin saturation, and ferritin).	Iron	111-115	vitamin D receptor	Homo sapiens	48-66
31679114-2	2020	This study investigated the association between vitamin D receptor (VDR) genetic variant (FokI) rs2228570 with iron indices (serum iron, transferrin, transferrin saturation, and ferritin).	Iron	111-115	vitamin D receptor	Homo sapiens	68-71
21330167-1	2011	The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ~1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe.	Iron	320-322	interleukin 6	Equus caballus	149-153
31518459-0	2020	Brain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.	Iron	6-10	chromosome 19 open reading frame 12	Homo sapiens	42-50
21903580-0	2011	5-aza-2"-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.	Iron	33-37	ferrochelatase	Mus musculus	172-186
21903580-0	2011	5-aza-2"-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.	Iron	33-37	ferrochelatase	Mus musculus	188-192
31518459-1	2020	BACKGROUND: Mitochondrial membrane protein-associated neurodegeneration is an autosomal-recessive disorder caused by C19orf12 mutations and characterized by iron deposits in the basal ganglia.	Iron	157-161	chromosome 19 open reading frame 12	Homo sapiens	117-125
31760034-0	2020	Iron chelators inhibit amyloid-beta-induced production of lipocalin 2 in cultured astrocytes.	Iron	0-4	lipocalin 2	Homo sapiens	58-69
21873546-9	2011	Similarly, hepcidin was up-regulated with concomitant lowering of serum iron during acute murine Influenza A/PR/8/34 virus (H1N1) infection.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	11-19
31760034-2	2020	Iron chelators were found to reduce Lcn2 levels in certain animal models of CNS injury.	Iron	0-4	lipocalin 2	Homo sapiens	36-40
31760034-3	2020	Focusing on Alzheimer"s disease (AD), we found that the iron chelators deferoxamine and deferiprone inhibited amyloid-beta (Abeta)-induced Lcn2 production in cultured primary astrocytes.	Iron	56-60	lipocalin 2	Homo sapiens	139-143
22102021-0	2011	Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae.	Iron	25-27	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	40-44
31760034-6	2020	Known neuroprotective effects of iron chelators may rely in part on normalization of Lcn2 levels.	Iron	33-37	lipocalin 2	Homo sapiens	85-89
22102021-2	2011	However, a high iron concentration in the mitochondria results in iron misincorporation at the active site, with subsequent inactivation of SOD2.	Iron	16-20	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	140-144
32759562-7	2020	In some anemic disorders, such as beta-thalassemia, and some categories of MDS, GDF15 or erythroferrone were overproduced and promoted iron absorption.	Iron	135-139	growth differentiation factor 15	Homo sapiens	80-85
22102021-3	2011	Here, the crystal structures of SOD2 bound with the native metal manganese and with the `wrong" metal iron are presented at 2.05 and 1.79 A resolution, respectively.	Iron	102-106	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	32-36
31633857-0	2019	Slow Dynamics of the Spin-Crossover Process in an Apparent High-Spin Mononuclear Fe(II) Complex.	Iron	81-87	spindlin 1	Homo sapiens	21-25
21763306-1	2011	BACKGROUND: We previously reported the overexpression of lipocalin2 (LCN2), a 25kDa secretory protein involved in iron-transportation, in endometrial carcinoma and its possible contribution to endometrial carcinogenesis.	Iron	114-118	lipocalin 2	Homo sapiens	57-67
31633857-0	2019	Slow Dynamics of the Spin-Crossover Process in an Apparent High-Spin Mononuclear Fe(II) Complex.	Iron	81-87	spindlin 1	Homo sapiens	64-68
21763306-1	2011	BACKGROUND: We previously reported the overexpression of lipocalin2 (LCN2), a 25kDa secretory protein involved in iron-transportation, in endometrial carcinoma and its possible contribution to endometrial carcinogenesis.	Iron	114-118	lipocalin 2	Homo sapiens	69-73
31633857-1	2019	A mononuclear Fe(II) complex, that shows a high-spin (S = 2) paramagnetic behavior at all temperatures (with standard temperature scan-rates, of about 1 Kmin -1 ), has indeed a low-spin (S = 0) ground state below 100 K. This low-spin state is not easily accessible due to the extremely slow dynamics of the spin-crossover process.	Iron	14-20	spindlin 1	Homo sapiens	48-52
31633857-1	2019	A mononuclear Fe(II) complex, that shows a high-spin (S = 2) paramagnetic behavior at all temperatures (with standard temperature scan-rates, of about 1 Kmin -1 ), has indeed a low-spin (S = 0) ground state below 100 K. This low-spin state is not easily accessible due to the extremely slow dynamics of the spin-crossover process.	Iron	14-20	spindlin 1	Homo sapiens	181-185
31633857-1	2019	A mononuclear Fe(II) complex, that shows a high-spin (S = 2) paramagnetic behavior at all temperatures (with standard temperature scan-rates, of about 1 Kmin -1 ), has indeed a low-spin (S = 0) ground state below 100 K. This low-spin state is not easily accessible due to the extremely slow dynamics of the spin-crossover process.	Iron	14-20	spindlin 1	Homo sapiens	181-185
21813652-0	2011	SO2907, a putative TonB-dependent receptor, is involved in dissimilatory iron reduction by Shewanella oneidensis strain MR-1.	Iron	73-77	TonB-dependent receptor	Shewanella oneidensis MR-1	0-6
31633857-1	2019	A mononuclear Fe(II) complex, that shows a high-spin (S = 2) paramagnetic behavior at all temperatures (with standard temperature scan-rates, of about 1 Kmin -1 ), has indeed a low-spin (S = 0) ground state below 100 K. This low-spin state is not easily accessible due to the extremely slow dynamics of the spin-crossover process.	Iron	14-20	spindlin 1	Homo sapiens	181-185
21813652-10	2011	Iron binding assays using isothermal titration calorimetry and fluorescence tryptophan quenching demonstrated that a truncated form of heterologous-expressed SO2907 that contains the Fe(III) binding site, is capable of binding soluble Fe(III) forms with K(d) of approximate 50 mum.	Iron	0-4	TonB-dependent receptor	Shewanella oneidensis MR-1	158-164
31633857-2	2019	Indeed, a full relaxation of the metastable high-spin state to the low-spin ground state takes more than five hours below 80 K. Bidirectional photoswitching of the Fe(II) state is achieved reproducibly by two selective irradiations (at 530-590 and 830-850 nm).	Iron	164-170	spindlin 1	Homo sapiens	49-53
21359952-12	2011	These results strongly implicate glucocorticoid receptor and STAT5 in stress-induced up-regulation of IRP-1, which subsequently enhances transferrin receptor-1 expression and down-regulates ferritin, causing iron accumulation in the liver.	Iron	208-212	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	33-56
31633857-2	2019	Indeed, a full relaxation of the metastable high-spin state to the low-spin ground state takes more than five hours below 80 K. Bidirectional photoswitching of the Fe(II) state is achieved reproducibly by two selective irradiations (at 530-590 and 830-850 nm).	Iron	164-170	spindlin 1	Homo sapiens	71-75
31669736-9	2019	KEY FINDINGS: HFe consumption caused an equal impact on circulating iron-overload, oxidative stress, and inflammation in WT and HT mice.	Iron	68-72	homeostatic iron regulator	Mus musculus	14-17
21753061-3	2011	The mRNA for HIF 2-alpha contains an IRE and undergoes iron-dependent regulation in vitro, though the translational regulation of HIF-2alpha in vivo remains unknown.	Iron	55-59	endothelial PAS domain protein 1	Rattus norvegicus	13-24
21753061-8	2011	Taken together, these results suggest that the translation of HIF-2alpha in the liver is regulated in part by the action of IRP in response to dietary iron deficiency and provide evidence that IRP may assist in coordinating the cellular response to alterations in iron and oxygen status associated with iron deficiency anemia.	Iron	151-155	endothelial PAS domain protein 1	Rattus norvegicus	62-72
31669736-10	2019	Brain iron-overload and iron-mediated neurotoxicity, such as oxidative stress, inflammation, glial activation, mitochondrial dysfunction, and Alzheimer"s like pathologies, were observed to an equal degree in HFe fed WT and HT mice.	Iron	6-10	homeostatic iron regulator	Mus musculus	208-211
31669736-10	2019	Brain iron-overload and iron-mediated neurotoxicity, such as oxidative stress, inflammation, glial activation, mitochondrial dysfunction, and Alzheimer"s like pathologies, were observed to an equal degree in HFe fed WT and HT mice.	Iron	24-28	homeostatic iron regulator	Mus musculus	208-211
31694915-6	2019	In cultured human kidney 2 (HK-2) cells, silenced Panx1 expression significantly attenuated ferroptotic lipid peroxidation and iron accumulation induced by the ferroptosis inducer erastin.	Iron	127-131	pannexin 1	Homo sapiens	50-55
21790804-5	2011	Both proteins are indispensable for growth, as they are required for the assembly of Fe-S clusters in mitochondrial aconitase, fumarase and succinate dehydrogenase.	Iron	85-89	fumarate hydratase	Homo sapiens	127-135
21609320-11	2011	In conclusion, the findings of the present study (i) indicate that GATA-4 may participate in the control of hepcidin expression, and (ii) suggest that alteration of its expression could contribute to the development of iron-related disorders.	Iron	219-223	GATA binding protein 4	Homo sapiens	67-73
31676601-10	2019	These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs.	Iron	90-94	ferritin heavy polypeptide 1	Mus musculus	34-37
31613630-5	2019	The iron-carrying CPNPs reported here are targeted to endothelin-B receptors (EDNRB) through endothelin-3 surface moieties (EDN3-CPNPs).	Iron	4-8	endothelin 3	Homo sapiens	93-105
21731964-8	2011	Factor 1 was characterized by a high positive contribution of the anthropogenic source elements, especially As, Pb, and Zn (37%), whereas Factor 2 was strongly correlated with the oxy-hydroxides of Fe and Mn (27%).	Iron	198-200	transcription termination factor 2	Homo sapiens	138-146
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	66-70	growth differentiation factor 15	Homo sapiens	0-32
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	66-70	growth differentiation factor 15	Homo sapiens	34-39
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	83-87	growth differentiation factor 15	Homo sapiens	0-32
31613630-5	2019	The iron-carrying CPNPs reported here are targeted to endothelin-B receptors (EDNRB) through endothelin-3 surface moieties (EDN3-CPNPs).	Iron	4-8	endothelin 3	Homo sapiens	124-128
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	83-87	growth differentiation factor 15	Homo sapiens	34-39
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	83-87	growth differentiation factor 15	Homo sapiens	0-32
31850722-6	2019	CHr is a good indication of iron availability and an early marker of iron deficient erythropoiesis which can be obtained readily using automated blood cell analyzers.	Iron	28-32	chromate resistance; sulfate transport	Homo sapiens	0-3
21475976-2	2011	Growth differentiation factor 15 (GDF15) was suggested to mediate iron overload in iron-loading anaemias, such as the thalassaemias and CDAI by suppressing hepcidin, the key regulator of iron absorption.	Iron	83-87	growth differentiation factor 15	Homo sapiens	34-39
21475976-6	2011	GDF15 significantly correlates with the degree of anaemia (Hb), the response of erythropoiesis (reticulocyte index) as well as with iron availability in the serum (transferrin saturation).	Iron	132-136	growth differentiation factor 15	Homo sapiens	0-5
21475976-7	2011	The observation that GDF15 is elevated in CDAII patients is consistent with the proposal that GDF15 is among the erythroid factors down-regulating hepcidin and contributing to iron overload in conditions of dyserythropoiesis.	Iron	176-180	growth differentiation factor 15	Homo sapiens	94-99
21104018-7	2011	These results suggest that FRO6 functions as a ferric chelate reductase for iron uptake by leaf cells, and overexpression of AtFRO6 in transgenic plants can reduce iron deficiency chlorosis.	Iron	76-80	ferric reduction oxidase 6	Arabidopsis thaliana	27-31
21511814-0	2011	Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.	Iron	32-36	DNL-type zinc finger	Homo sapiens	0-5
21511814-3	2011	Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron-sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination.	Iron	81-85	DNL-type zinc finger	Homo sapiens	42-47
21511814-3	2011	Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron-sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination.	Iron	81-85	DNL-type zinc finger	Homo sapiens	55-59
21511814-3	2011	Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron-sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination.	Iron	184-188	DNL-type zinc finger	Homo sapiens	42-47
21511814-3	2011	Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron-sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination.	Iron	184-188	DNL-type zinc finger	Homo sapiens	55-59
21683124-7	2011	We demonstrated by RT-PCR that increased cellular iron levels enhanced the expression of MMP-9 in activated microglia, but had no effect on MMP-1.	Iron	50-54	matrix metallopeptidase 9	Rattus norvegicus	89-94
21683124-8	2011	Studies using western blot and gelatin zymography analyses demonstrated that increased cellular iron levels in activated microglia enhanced the secretion of MMP-9 and MMP-1.	Iron	96-100	matrix metallopeptidase 9	Rattus norvegicus	157-162
21421891-1	2011	OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) is a ubiquitous lipocalin that serves as a critical component of innate immunity and a transport shuttle for numerous substances (retinoids, arachidonic acid, prostaglandins, fatty acids, steroids, iron, and MMPs).	Iron	259-263	lipocalin 2	Homo sapiens	11-53
21421891-1	2011	OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) is a ubiquitous lipocalin that serves as a critical component of innate immunity and a transport shuttle for numerous substances (retinoids, arachidonic acid, prostaglandins, fatty acids, steroids, iron, and MMPs).	Iron	259-263	lipocalin 2	Homo sapiens	55-59
21299470-3	2011	In Saccharomyces cerevisiae, the multidomain Grx3 and Grx4 play an essential role in intracellular iron trafficking.	Iron	99-103	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	45-49
21299470-8	2011	Grx4 functions as iron sensor for the iron-sensing transcription factor Aft1 in S. cerevisiae.	Iron	18-22	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	72-76
21299470-8	2011	Grx4 functions as iron sensor for the iron-sensing transcription factor Aft1 in S. cerevisiae.	Iron	38-42	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	72-76
21575136-6	2011	Furthermore, Grx3 inhibited iron accumulation in yeast grx3gxr4 cells and suppressed the sensitivity of mutant cells to exogenous oxidants.	Iron	28-32	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	13-17
21488083-2	2011	However, the molecular mechanisms by which iron is sensed to regulate BMP6-SMAD signaling and hepcidin expression are unknown.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	94-102
21488083-4	2011	We demonstrated that both transferrin saturation and liver iron content independently influence hepcidin expression.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	96-104
21488083-8	2011	CONCLUSION: Our data demonstrate that the hepatic Bmp6-Smad signaling pathway is differentially activated by circulating and tissue iron to induce hepcidin expression, whereas the hepatic Erk1/2 signaling pathway is not activated by iron in vivo.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	147-155
21922821-4	2011	It is demonstrated that SRB-Cu/Fe bimetallic system perform much better than traditional SRB system or copper-iron bimetallic.	Iron	31-33	chaperonin containing TCP1 subunit 4	Homo sapiens	24-27
24250389-1	2011	Hepcidin is an innate immune element which decreases the iron absorption from diet and iron releasing from macrophage cell.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	0-8
24250389-1	2011	Hepcidin is an innate immune element which decreases the iron absorption from diet and iron releasing from macrophage cell.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	0-8
21636783-6	2011	In the complex the [2Fe-2S] cluster of Adx is positioned 17.4 A away from the heme iron of CYP11A1.	Iron	83-87	ferredoxin 1	Homo sapiens	39-42
21315474-3	2011	From microarray analysis of Arabidopsis roots, it is known that three different cytochrome P450 genes, CYP82C4, CYP82C3 and CYP71B5 are up-regulated under Fe deficiency through a FIT-dependent pathway.	Iron	155-157	cytochrome P450, family 82, subfamily C, polypeptide 3	Arabidopsis thaliana	112-119
21493799-1	2011	Hepcidin, a hormone produced mainly by the liver, has been shown to inhibit both intestinal iron absorption and iron release from macrophages.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	0-8
21493799-1	2011	Hepcidin, a hormone produced mainly by the liver, has been shown to inhibit both intestinal iron absorption and iron release from macrophages.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	0-8
21493799-3	2011	In the present study, we show in mice that loss of hemojuvelin specifically in the liver leads to decreased liver hepcidin production and increased tissue and serum iron levels.	Iron	165-169	hemojuvelin BMP co-receptor	Mus musculus	51-62
20723953-1	2011	Hepcidin is part of the innate immune system, and it plays a central role in the regulation of iron homeostasis.	Iron	95-99	hepcidin	Ovis aries	0-8
21440316-1	2011	Hepcidin is a highly conserved disulfide-bonded peptide that plays a central role in iron homeostasis.	Iron	85-89	hepcidin	Ovis aries	0-8
21440316-7	2011	These findings extend our knowledge on the relationship between the systemic inflammatory response, hepcidin and iron, and provide a starting point for additional studies on iron metabolism and the inflammatory process in sheep.	Iron	113-117	hepcidin	Ovis aries	100-108
21654899-4	2011	In several kinds of protein complexes exemplified by methemoglobin, transferrin or ferritin, various forms of trivalent iron have been found.	Iron	120-124	hemoglobin subunit gamma 2	Homo sapiens	53-66
21378183-0	2011	The YaaA protein of the Escherichia coli OxyR regulon lessens hydrogen peroxide toxicity by diminishing the amount of intracellular unincorporated iron.	Iron	147-151	hypothetical protein	Escherichia coli	4-8
21378183-8	2011	The growth defect of yaaA mutants could be suppressed by either the addition of iron chelators or mutations that slowed iron import, indicating that the DNA damage was caused by the Fenton reaction.	Iron	80-84	hypothetical protein	Escherichia coli	21-25
21378183-8	2011	The growth defect of yaaA mutants could be suppressed by either the addition of iron chelators or mutations that slowed iron import, indicating that the DNA damage was caused by the Fenton reaction.	Iron	120-124	hypothetical protein	Escherichia coli	21-25
21378183-11	2011	These results demonstrate that during periods of H(2)O(2) stress the induction of YaaA is a critical device to suppress intracellular iron levels; it thereby attenuates the Fenton reaction and the DNA damage that would otherwise result.	Iron	134-138	hypothetical protein	Escherichia coli	82-86
21586684-0	2011	Interaction between the bHLH transcription factor FIT and ETHYLENE INSENSITIVE3/ETHYLENE INSENSITIVE3-LIKE1 reveals molecular linkage between the regulation of iron acquisition and ethylene signaling in Arabidopsis.	Iron	160-164	ETHYLENE-INSENSITIVE3-like 1	Arabidopsis thaliana	80-107
21586684-6	2011	We demonstrate that the ein3 eil1 transcriptome was affected to a greater extent upon iron deficiency than normal iron compared with the wild type.	Iron	86-90	ETHYLENE-INSENSITIVE3-like 1	Arabidopsis thaliana	29-33
21496220-0	2011	Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy.	Iron	70-74	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	12-15
21292994-7	2011	When challenged with the high-iron diet, Bmp6 and Hfe expression was significantly increased.	Iron	30-34	homeostatic iron regulator	Mus musculus	50-53
21292994-11	2011	The iron-induced increase in hepcidin peptide in turn suppresses ferroportin protein levels, thus nullifying the upregulation of mRNA expression in response to increased OS.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	29-37
21455261-3	2011	These iron sources are transported into the Gram-negative bacterial cell through an outer membrane receptor, a periplasmic binding protein (PBP), and an inner membrane ATP-binding cassette (ABC) transporter.	Iron	6-10	phosphatidylethanolamine binding protein 1	Homo sapiens	111-138
21455261-3	2011	These iron sources are transported into the Gram-negative bacterial cell through an outer membrane receptor, a periplasmic binding protein (PBP), and an inner membrane ATP-binding cassette (ABC) transporter.	Iron	6-10	phosphatidylethanolamine binding protein 1	Homo sapiens	140-143
21029774-6	2011	In addition, Mt-FTL/FTH1 heteropolymers formed aggregates during iron loading, contrasting Wt-FTL/FTH1 heteropolymers and similar to what was seen for Mt-FTL homopolymers.	Iron	65-69	ferritin light chain	Homo sapiens	16-19
21029774-8	2011	The presence of Mt-FTL subunits in Mt-FTL/Wt-FTL heteropolymers also caused iron loading-induced aggregation relative to Wt-FTL homopolymers, with the precipitate containing Mt- and Wt-FTL polypeptides again paralleling HF.	Iron	76-80	ferritin light chain	Homo sapiens	19-22
21029774-8	2011	The presence of Mt-FTL subunits in Mt-FTL/Wt-FTL heteropolymers also caused iron loading-induced aggregation relative to Wt-FTL homopolymers, with the precipitate containing Mt- and Wt-FTL polypeptides again paralleling HF.	Iron	76-80	ferritin light chain	Homo sapiens	38-41
21213119-2	2011	Neuronal iron uptake is reflected in a robust and consistent expression of transferrin receptors and divalent metal transporter 1 (DMT 1).	Iron	9-13	transferrin	Mus musculus	75-86
21213119-12	2011	The data therefore indicate that neuronal iron homeostasis consists of a delicate balance between transferrin receptor-mediated uptake of iron-transferrin and ferroportin-related iron excretion.	Iron	42-46	transferrin	Mus musculus	98-109
21213119-12	2011	The data therefore indicate that neuronal iron homeostasis consists of a delicate balance between transferrin receptor-mediated uptake of iron-transferrin and ferroportin-related iron excretion.	Iron	42-46	transferrin	Mus musculus	143-154
21213119-12	2011	The data therefore indicate that neuronal iron homeostasis consists of a delicate balance between transferrin receptor-mediated uptake of iron-transferrin and ferroportin-related iron excretion.	Iron	138-142	transferrin	Mus musculus	98-109
21213119-12	2011	The data therefore indicate that neuronal iron homeostasis consists of a delicate balance between transferrin receptor-mediated uptake of iron-transferrin and ferroportin-related iron excretion.	Iron	138-142	transferrin	Mus musculus	143-154
21213119-12	2011	The data therefore indicate that neuronal iron homeostasis consists of a delicate balance between transferrin receptor-mediated uptake of iron-transferrin and ferroportin-related iron excretion.	Iron	138-142	transferrin	Mus musculus	98-109
21213119-12	2011	The data therefore indicate that neuronal iron homeostasis consists of a delicate balance between transferrin receptor-mediated uptake of iron-transferrin and ferroportin-related iron excretion.	Iron	138-142	transferrin	Mus musculus	143-154
21213119-13	2011	The findings also suggest a particular high turnover of iron in neuronal regions, such as habenula, hippocampus, reticular formation and cerebellum, as several neurons in these regions exhibit a prominent co-expression of transferrin receptors and ferroportin.	Iron	56-60	transferrin	Mus musculus	222-233
21558026-0	2011	Induction of hypoxia inducible factor (HIF-1alpha) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.	Iron	69-73	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	39-49
21558026-1	2011	Hypoxia inducible factor (HIF-1alpha) is a master regulator of tissue adaptive responses to hypoxia whose stability is controlled by an iron containing prolyl hydroxylase domain (PHD) protein.	Iron	136-140	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	26-36
21558026-2	2011	A catalytic redox cycle in the PHD"s iron center that results in the formation of a ferryl (Fe(+4)) intermediate has been reported to be responsible for the hydroxylation and subsequent degradation of HIF-1alpha under normoxia.	Iron	37-41	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	201-211
21558026-3	2011	We show that induction of HIF-1alpha in rat kidneys can be achieved by iron reduction by the hydroxypyridin-4 one (CP94), an iron chelator administered intraperitoneally in rats.	Iron	71-75	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	26-36
21558026-3	2011	We show that induction of HIF-1alpha in rat kidneys can be achieved by iron reduction by the hydroxypyridin-4 one (CP94), an iron chelator administered intraperitoneally in rats.	Iron	125-129	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	26-36
21427356-4	2011	beta2-M interacts with its receptor, hemochromatosis (HFE) protein, to modulate iron responsive pathways in cancer cells.	Iron	80-84	homeostatic iron regulator	Mus musculus	54-57
21480335-5	2011	After a 21-day (chronic) iron challenge, Hfe and Tfr2 mutant mice increased hepcidin expression to nearly wild-type levels, but a blunted increase of hepcidin was seen in Bmp6(-/-) and Hjv(-/-) mice.	Iron	25-29	homeostatic iron regulator	Mus musculus	41-44
21480335-5	2011	After a 21-day (chronic) iron challenge, Hfe and Tfr2 mutant mice increased hepcidin expression to nearly wild-type levels, but a blunted increase of hepcidin was seen in Bmp6(-/-) and Hjv(-/-) mice.	Iron	25-29	transferrin receptor 2	Mus musculus	49-53
21480335-5	2011	After a 21-day (chronic) iron challenge, Hfe and Tfr2 mutant mice increased hepcidin expression to nearly wild-type levels, but a blunted increase of hepcidin was seen in Bmp6(-/-) and Hjv(-/-) mice.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	76-84
21480335-6	2011	BMP6, whose expression is also regulated by iron, may mediate hepcidin regulation by iron stores.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	62-70
21480335-6	2011	BMP6, whose expression is also regulated by iron, may mediate hepcidin regulation by iron stores.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	62-70
21480335-8	2011	CONCLUSION: TfR2, HJV, BMP6, and, to a lesser extent, HFE are required for the hepcidin response to acute iron loading, but are partially redundant for hepcidin regulation during chronic iron loading and are not involved in the regulation of BMP6 expression.	Iron	106-110	transferrin receptor 2	Mus musculus	12-16
21480335-8	2011	CONCLUSION: TfR2, HJV, BMP6, and, to a lesser extent, HFE are required for the hepcidin response to acute iron loading, but are partially redundant for hepcidin regulation during chronic iron loading and are not involved in the regulation of BMP6 expression.	Iron	106-110	homeostatic iron regulator	Mus musculus	54-57
21480335-8	2011	CONCLUSION: TfR2, HJV, BMP6, and, to a lesser extent, HFE are required for the hepcidin response to acute iron loading, but are partially redundant for hepcidin regulation during chronic iron loading and are not involved in the regulation of BMP6 expression.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	79-87
21480335-10	2011	A distinct regulatory mechanism that senses hepatic iron may modulate hepcidin response to chronic iron loading.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	70-78
21480335-10	2011	A distinct regulatory mechanism that senses hepatic iron may modulate hepcidin response to chronic iron loading.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	70-78
21191310-9	2011	Duodenal cytochrome b (Dcyt-b), divalent metal transporter 1 (DMT-1), and ferroportin are the crucial regulators of intestinal iron transport and absorption.	Iron	127-131	RoBo-1	Rattus norvegicus	32-60
21191310-9	2011	Duodenal cytochrome b (Dcyt-b), divalent metal transporter 1 (DMT-1), and ferroportin are the crucial regulators of intestinal iron transport and absorption.	Iron	127-131	RoBo-1	Rattus norvegicus	62-67
21518525-0	2011	[Effect of GDF15 on iron overloading and erythropoiesis].	Iron	20-24	growth differentiation factor 15	Homo sapiens	11-16
21518525-6	2011	The regulation of GDF15 may also be related to iron levels, epigenetic regulation and hypoxia.	Iron	47-51	growth differentiation factor 15	Homo sapiens	18-23
21245482-1	2011	The induction of the iron-regulatory peptide hepcidin by proinflammatory cytokines is thought to result in the withholding of iron from invading pathogens.	Iron	21-25	hepcidin antimicrobial peptide	Mus musculus	45-53
20690031-6	2011	However, while silencing the expression of alpha-synuclein in SK-N-SH cells with siRNA, iron-induced toxicity could be partially alleviated, indicated by the returned Deltapsi(m) and cell viability and reduced ROS formation compared with that of control.	Iron	88-92	hedgehog acyltransferase	Homo sapiens	62-66
21301110-2	2011	Metallic flavours are often caused by the dissolved iron and copper, commonly found in groundwater or introduced to tap water by corroding infrastructure.	Iron	52-56	nuclear RNA export factor 1	Homo sapiens	116-119
21266164-1	2011	Jumonji domain containing iron (II), 2-oxoglutarate (2OG)-dependent dioxygenases from Jmjd2 family demethylate trimethylated histone3-lysine 9 (H3-K9me3), and also H3-K9me2 and H3-K36me3, albeit at lower rates.	Iron	26-30	lysine demethylase 4A	Homo sapiens	86-91
21115498-1	2011	Heme oxygenase-1 (HO-1) is a stress-inducible enzyme catalyzing the oxidative degradation of heme to free iron, CO, and biliverdin.	Iron	106-110	heme oxygenase 1	Rattus norvegicus	0-16
21115498-1	2011	Heme oxygenase-1 (HO-1) is a stress-inducible enzyme catalyzing the oxidative degradation of heme to free iron, CO, and biliverdin.	Iron	106-110	heme oxygenase 1	Rattus norvegicus	18-22
21291567-9	2011	Hepatic iron increase in the mice given either T. occidentalis or FeSO4 led to a corresponding enhancement of hepcidin mRNA expression.	Iron	8-12	hepcidin antimicrobial peptide	Mus musculus	110-118
21291567-10	2011	Induced hepcidin mRNA expression was enhanced by the addition of ascorbic acid to the test dose of iron.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	8-16
21291567-11	2011	Hepatic hepcidin mRNA expression was found to be responsive to increase in the relative bioavailability of iron from test diets.	Iron	107-111	hepcidin antimicrobial peptide	Mus musculus	8-16
21059897-0	2011	Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis.	Iron	95-99	homeostatic iron regulator	Mus musculus	60-63
21059897-1	2011	In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin.	Iron	56-60	homeostatic iron regulator	Mus musculus	44-47
21059897-1	2011	In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	103-111
21059897-2	2011	In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis.	Iron	48-52	homeostatic iron regulator	Mus musculus	13-16
21059897-2	2011	In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis.	Iron	48-52	transferrin	Mus musculus	80-91
21059897-4	2011	We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake.	Iron	70-74	homeostatic iron regulator	Mus musculus	20-23
21059897-4	2011	We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake.	Iron	100-104	homeostatic iron regulator	Mus musculus	20-23
21059897-5	2011	To investigate this, we used Hfe-KO mice in conditions of altered dietary iron and erythropoiesis.	Iron	74-78	homeostatic iron regulator	Mus musculus	29-32
21059897-6	2011	We show that Hfe-KO mice can overcome phlebotomy-induced anemia more rapidly than wild-type mice (even when iron loaded).	Iron	108-112	homeostatic iron regulator	Mus musculus	13-16
21059897-8	2011	Our results suggest that lack of Hfe is advantageous in conditions of increased erythropoietic activity because of augmented iron mobilization driven by deficient hepcidin response.	Iron	125-129	homeostatic iron regulator	Mus musculus	33-36
21059897-9	2011	Lastly, we demonstrate that Hfe is expressed in erythroid cells and impairs iron uptake, whereas its absence exclusively from the hematopoietic compartment is sufficient to accelerate recovery from phlebotomy.	Iron	76-80	homeostatic iron regulator	Mus musculus	28-31
21059897-10	2011	In summary, we demonstrate that Hfe influences erythropoiesis by 2 distinct mechanisms: limiting hepcidin expression under conditions of simultaneous iron overload and stress erythropoiesis, and impairing transferrin-bound iron uptake by erythroid cells.	Iron	150-154	homeostatic iron regulator	Mus musculus	32-35
31850722-7	2019	Therefore, the main objective of the current review is to assess the role of CHr for diagnosis of iron deficiency, iron deficiency anemia, and monitoring of iron therapy.	Iron	98-102	chromate resistance; sulfate transport	Homo sapiens	77-80
21059897-10	2011	In summary, we demonstrate that Hfe influences erythropoiesis by 2 distinct mechanisms: limiting hepcidin expression under conditions of simultaneous iron overload and stress erythropoiesis, and impairing transferrin-bound iron uptake by erythroid cells.	Iron	150-154	hepcidin antimicrobial peptide	Mus musculus	97-105
21059897-10	2011	In summary, we demonstrate that Hfe influences erythropoiesis by 2 distinct mechanisms: limiting hepcidin expression under conditions of simultaneous iron overload and stress erythropoiesis, and impairing transferrin-bound iron uptake by erythroid cells.	Iron	223-227	homeostatic iron regulator	Mus musculus	32-35
31850722-9	2019	RESULTS: According to this review, CHr has a moderate sensitivity and specificity for diagnosing iron deficiency, and is less affected by inflammation than serum iron, transferrin saturation, and ferritin and is an early predictor of treatment response.	Iron	97-101	chromate resistance; sulfate transport	Homo sapiens	35-38
21059897-10	2011	In summary, we demonstrate that Hfe influences erythropoiesis by 2 distinct mechanisms: limiting hepcidin expression under conditions of simultaneous iron overload and stress erythropoiesis, and impairing transferrin-bound iron uptake by erythroid cells.	Iron	223-227	transferrin	Mus musculus	205-216
31850722-16	2019	Moreover, since CHr can be affected with any conditions that cause iron restricted erythropoiesis, further analysis may be needed.	Iron	67-71	chromate resistance; sulfate transport	Homo sapiens	16-19
20940420-1	2011	Hepcidin is the master regulator of iron homeostasis.	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	0-8
20940420-2	2011	In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6).	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	29-37
20940420-2	2011	In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6).	Iron	14-18	hemojuvelin BMP co-receptor	Mus musculus	101-112
20940420-2	2011	In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6).	Iron	14-18	hemojuvelin BMP co-receptor	Mus musculus	114-117
20940420-2	2011	In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6).	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	161-169
31211687-1	2019	Background In hereditary hyperferritinaemia-cataract syndrome (HHCS), single nucleic acid alterations in the ferritin light chain (L-ferritin) iron response element (IRE) constitutively derepress ferritin synthesis, resulting in hyperferritinaemia, L-ferritin deposits in the lens of the eye and early bilateral cataract onset.	Iron	143-147	ferritin light chain	Homo sapiens	109-129
20956801-1	2011	As a central regulator of iron metabolism, hepcidin inhibits dietary iron absorption and macrophage iron recycling.	Iron	26-30	hepcidin antimicrobial peptide	Mus musculus	43-51
20956801-1	2011	As a central regulator of iron metabolism, hepcidin inhibits dietary iron absorption and macrophage iron recycling.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	43-51
20956801-1	2011	As a central regulator of iron metabolism, hepcidin inhibits dietary iron absorption and macrophage iron recycling.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	43-51
20956801-4	2011	These Tf-deficient mice have severe microcytic anemia, tissue iron overload, and hepcidin deficiency.	Iron	62-66	transferrin	Mus musculus	6-8
31657383-3	2019	The non-linear effect, X-ray crystal structure and ESI-MS suggest that a 2 : 1 complex of (S)-xylyl-iPrO-BIPHEP-oxide and Fe(OTf)2 is a pre-catalyst for a Fe(iii)/Fe(iv) redox cycle.	Iron	155-162	POU class 2 homeobox 2	Homo sapiens	125-130
21502756-1	2011	BACKGROUND/AIMS: Fibroblast growth factor-23 (FGF23) plays a central role in the development of hypophosphatemia and inappropriately low 1,25-dihydroxyvitamin D induced by iron therapy for iron-deficiency anemia.	Iron	172-176	fibroblast growth factor 23	Homo sapiens	17-44
21502756-1	2011	BACKGROUND/AIMS: Fibroblast growth factor-23 (FGF23) plays a central role in the development of hypophosphatemia and inappropriately low 1,25-dihydroxyvitamin D induced by iron therapy for iron-deficiency anemia.	Iron	172-176	fibroblast growth factor 23	Homo sapiens	46-51
31657383-3	2019	The non-linear effect, X-ray crystal structure and ESI-MS suggest that a 2 : 1 complex of (S)-xylyl-iPrO-BIPHEP-oxide and Fe(OTf)2 is a pre-catalyst for a Fe(iii)/Fe(iv) redox cycle.	Iron	122-124	POU class 2 homeobox 2	Homo sapiens	125-130
31744922-7	2019	Iron regulation genes ybtA and fyuA were found to be indirectly regulated by Crp.	Iron	0-4	C-reactive protein, pentraxin-related	Mus musculus	77-80
29861700-0	2011	Minerals (Zn, Fe, Ca and Mg) and Antinutrient (Phytic Acid) Constituents in Common Bean.	Iron	14-16	brain expressed associated with NEDD4 1	Homo sapiens	83-87
31725784-5	2019	The mineral absorption pathway genes, HMOX1 and VDR are involved in iron metabolism and response to vitamin D, respectively.	Iron	68-72	vitamin D receptor	Homo sapiens	48-51
20422170-1	2011	Heme oxygenase-1 (HO-1), an inducible enzyme, degrades heme to carbon monoxide (CO), iron, and bilirubin.	Iron	85-89	heme oxygenase 1	Rattus norvegicus	0-16
20422170-1	2011	Heme oxygenase-1 (HO-1), an inducible enzyme, degrades heme to carbon monoxide (CO), iron, and bilirubin.	Iron	85-89	heme oxygenase 1	Rattus norvegicus	18-22
31685920-3	2019	The as-obtained CoFe and NiFe hollow cages (CFHC and NFHC) can be directly utilized as electrocatalysts towards oxygen evolution reaction (OER) and urea oxidation reaction (UOR) with superior catalytic performance (lower electrolysis potential, faster reaction kinetics and long-term durability) compared to their parent solid precursors (CFC and NFC) and even the commercial noble metal-based catalyst.	Iron	16-20	tubulin folding cofactor C	Homo sapiens	339-342
21325818-5	2011	Expression levels of iron transport proteins including DMT1, TfR, Fpn1 and Heph were assessed by Western blot technique.	Iron	21-25	RoBo-1	Rattus norvegicus	55-59
31573185-1	2019	The diamagnetic two-dimensional Hofmann-type metal-organic framework [ZnII(2-mpz)2Ni(CN)4] has been successfully synthesized along with its isostructural hysteretic spin-crossover FeII analogue in the form of both bulk microcrystalline powder and nanoparticles.	Iron	180-184	spindlin 1	Homo sapiens	165-169
21852895-1	2011	Ferrochelatase (also known as PPIX ferrochelatase; Enzyme Commission number 4.9.9.1.1) catalyzes the insertion of ferrous iron into PPIX to form heme.	Iron	114-126	ferrochelatase	Homo sapiens	35-49
21852895-5	2011	It is generally believed that ferrous iron is directly channeled to ferrochelatase in vivo, but the identity of the suspected chaperone remains uncertain despite much recent progress in this area.	Iron	38-42	ferrochelatase	Homo sapiens	68-82
21949882-4	2011	Here we have studied the 2OG and iron (Fe(II)) dependent dioxygenase Ofd2 in Schizosaccharomyces pombe, a member of the AlkB subfamily of dioxygenases.	Iron	33-37	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	120-124
31029830-3	2019	The AM of biodegradable metals including magnesium (Mg), iron (Fe), and zinc (Zn) is still in its infancy, although much progress has been made in the research field.	Iron	57-61	general transcription factor IIE subunit 1	Homo sapiens	63-65
21801495-1	2011	Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-kappaB1(p50).	Iron	0-4	pirin	Mus musculus	21-26
31330363-8	2019	Nine constituents (OC, EC, K, Fe, Zn, Ba, Cr, Se, and Pb) showed consistent associations with elevated FeNO and decreased NOS2A methylation or increased ARG2 methylation in single-constituent models and models adjusting for PM2.5 total mass and collinearity.	Iron	30-32	arginase 2	Homo sapiens	153-157
21977664-6	2011	The Ni and Fe dispersion determined from the TPR results was higher for the catalysts with a lower Ni or Fe content and decreased for higher Ni or Fe contents.	Iron	11-13	translocated promoter region, nuclear basket protein	Homo sapiens	45-48
31422079-0	2019	Effect of long-term proton pump inhibitor therapy on hemoglobin and serum iron levels after sleeve gastrectomy.	Iron	74-78	ATPase H+/K+ transporting subunit alpha	Homo sapiens	20-31
21977664-6	2011	The Ni and Fe dispersion determined from the TPR results was higher for the catalysts with a lower Ni or Fe content and decreased for higher Ni or Fe contents.	Iron	105-107	translocated promoter region, nuclear basket protein	Homo sapiens	45-48
21977664-6	2011	The Ni and Fe dispersion determined from the TPR results was higher for the catalysts with a lower Ni or Fe content and decreased for higher Ni or Fe contents.	Iron	105-107	translocated promoter region, nuclear basket protein	Homo sapiens	45-48
21041086-0	2010	A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol.	Iron	90-92	tyrosinase	Homo sapiens	44-54
21041086-1	2010	The iron-ion catalyzed oxidation of the ethanol solution of rosmarinic acid, a potent antioxidant polyphenol of Lamiaceae (Labiatae) plants, afforded a highly tyrosinase-inhibitory active product.	Iron	4-8	tyrosinase	Homo sapiens	159-169
31229649-0	2019	Drosophila ZIP13 is posttranslationally regulated by iron-mediated stabilization.	Iron	53-57	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	11-16
31229649-1	2019	Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly.	Iron	90-94	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	11-16
20923770-1	2010	Arn1 is an integral membrane protein that mediates the uptake of ferrichrome, an important nutritional source of iron, in Saccharomyces cerevisiae.	Iron	113-117	siderophore transporter	Saccharomyces cerevisiae S288C	0-4
31229649-1	2019	Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly.	Iron	90-94	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	18-24
31229649-1	2019	Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly.	Iron	90-94	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	33-39
31229649-2	2019	In this study, we show that dZIP13 level is strongly regulated by iron.	Iron	66-70	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	28-34
21099105-2	2010	Inappropriately low levels of hepcidin, a negative regulator of iron absorption and recycling, underlie the pathophysiology of the intestinal hyperabsorption.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	30-38
31229649-3	2019	In addition to a mild response to iron at the mRNA level, dZIP13 is strongly regulated at the protein level.	Iron	34-38	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	58-64
21099105-4	2010	demonstrate that increasing hepcidin expression to induce iron deficiency in murine beta-thalassemia not only mitigates the iron overload, but also the severity of the anemia.	Iron	58-62	hepcidin antimicrobial peptide	Mus musculus	28-36
21099105-5	2010	These data illustrate the therapeutic potential of modulating hepcidin expression in diseases associated with altered iron metabolism.	Iron	118-122	hepcidin antimicrobial peptide	Mus musculus	62-70
31229649-4	2019	This posttranslational regulation by iron also happens when dZIP13 is expressed in the yeast Saccharomyces cerevisiae.	Iron	37-41	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	60-66
20626630-7	2010	RESULTS: Intranigral infusion of iron time-dependently increased alpha-synuclein aggregation and haem oxygenase-1 levels.	Iron	33-37	synuclein alpha	Rattus norvegicus	65-80
31229649-5	2019	Iron functions to stabilize dZIP13.	Iron	0-4	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	28-34
20626630-10	2010	However, pioglitazone inhibited iron-induced alpha-synuclein aggregation, elevations in interleukin-1beta and interleukin-6 mRNA levels as well as increases in oxygenase-1, cyclo-oxygenase II, nitric oxide synthase and ED-1 protein levels, an indicator of activated microglia.	Iron	32-36	synuclein alpha	Rattus norvegicus	45-60
31229649-6	2019	Domain-swapping experiments between dZIP7 (CG10449/ Catsup) and dZIP13 suggest that the N-terminus of dZIP13 is necessary to mediate this iron regulatory process.	Iron	138-142	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	64-70
31229649-6	2019	Domain-swapping experiments between dZIP7 (CG10449/ Catsup) and dZIP13 suggest that the N-terminus of dZIP13 is necessary to mediate this iron regulatory process.	Iron	138-142	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	102-108
31229649-8	2019	Mutations of these potential iron binding sites at the N-terminus, as well as a likely iron binding site at the C-terminus of dZIP13, completely abolish the iron-dependent upregulation in the yeast and the fruit fly.	Iron	87-91	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	126-132
21084725-3	2010	In this study, we generated mice transgenically over-expressing the mitochondrial protein frataxin, which promotes mitochondrial energy conversion by controlling iron-sulfur-cluster biogenesis and hereby mitochondrial electron flux.	Iron	162-166	frataxin	Mus musculus	90-98
31229649-8	2019	Mutations of these potential iron binding sites at the N-terminus, as well as a likely iron binding site at the C-terminus of dZIP13, completely abolish the iron-dependent upregulation in the yeast and the fruit fly.	Iron	87-91	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	126-132
31229649-9	2019	Iron-responsiveness of dZIP13 is consistent with its key role in iron homeostasis.	Iron	0-4	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	23-29
31229649-9	2019	Iron-responsiveness of dZIP13 is consistent with its key role in iron homeostasis.	Iron	65-69	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	23-29
22419934-5	2010	In univariate analysis, NGAL correlated with serum cystatin C, number of pregnancies, white blood cell count, total iron-binding capacity (TIBC), ferritin, and IL-6, and tended to correlate with eGFR.	Iron	116-120	lipocalin 2	Homo sapiens	24-28
31229649-10	2019	We speculate that this process of dZIP13 regulation, and that of IRE/IRP-controlled ferritin production, work together to better cope with iron repletion in the fly.	Iron	139-143	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	34-40
31229649-10	2019	We speculate that this process of dZIP13 regulation, and that of IRE/IRP-controlled ferritin production, work together to better cope with iron repletion in the fly.	Iron	139-143	ire	Drosophila melanogaster	65-68
20578964-0	2010	High resolution melting for the identification of mutations in the iron responsive element of the ferritin light chain gene.	Iron	67-71	ferritin light chain	Homo sapiens	98-118
30792208-2	2019	The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading to excessive intestinal iron absorption and iron efflux from macrophages.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	86-94
20578964-2	2010	It is caused by mutations in the iron responsive element (IRE) of the ferritin light chain gene (FTL).	Iron	33-37	ferritin light chain	Homo sapiens	70-90
20578964-2	2010	It is caused by mutations in the iron responsive element (IRE) of the ferritin light chain gene (FTL).	Iron	33-37	ferritin light chain	Homo sapiens	97-100
30792208-2	2019	The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading to excessive intestinal iron absorption and iron efflux from macrophages.	Iron	141-145	hepcidin antimicrobial peptide	Mus musculus	86-94
20817231-3	2010	The present review will describe the parkinsonian phenotypes emerging from the new Mendelian genes which have been linked to PD (such as PARK9 and PARK14), the associated dystonia-parkinsonism disorders (such as the syndromes of neurodegeneration with brain iron accumulation) and the emerging data on heterozygous variants of genes which could influence the risk to develop PD and the PD phenotypes (like PD associated with glucose cerebrosidase mutations).	Iron	258-262	ATPase cation transporting 13A2	Homo sapiens	137-142
30792208-2	2019	The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading to excessive intestinal iron absorption and iron efflux from macrophages.	Iron	141-145	hepcidin antimicrobial peptide	Mus musculus	86-94
20121342-2	2010	Adult iron-regulatory protein 2 knockout (Ireb2(-/-)) mice develop iron accumulation in white matter tracts and nuclei in different brain area and display severe neurodegeneration in Purkinje cells of the cerebrum.	Iron	6-10	iron responsive element binding protein 2	Mus musculus	42-47
20121342-2	2010	Adult iron-regulatory protein 2 knockout (Ireb2(-/-)) mice develop iron accumulation in white matter tracts and nuclei in different brain area and display severe neurodegeneration in Purkinje cells of the cerebrum.	Iron	67-71	iron responsive element binding protein 2	Mus musculus	42-47
30792208-3	2019	Hepcidin agonists would therefore be expected to ameliorate iron overload in hereditary hemochromatosis and beta-thalassemia.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	0-8
30792208-10	2019	By increasing hepcidin production, thiazolidinone compounds may provide a useful alternative for the treatment of iron-overload disorders.	Iron	114-118	hepcidin antimicrobial peptide	Mus musculus	14-22
31493153-0	2019	The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2.	Iron	37-41	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	133-137
20816093-1	2010	To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	114-122
31493153-0	2019	The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2.	Iron	66-70	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	133-137
20816093-1	2010	To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	114-122
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	92-96	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	55-59
20816093-1	2010	To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	114-122
20816093-2	2010	Hepcidin limits basolateral iron efflux from the duodenal epithelium by binding and downregulating the intestinal iron exporter ferroportin.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	0-8
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	160-164	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	55-59
20816093-2	2010	Hepcidin limits basolateral iron efflux from the duodenal epithelium by binding and downregulating the intestinal iron exporter ferroportin.	Iron	114-118	hepcidin antimicrobial peptide	Mus musculus	0-8
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	160-164	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	55-59
20572014-11	2010	Additionally, a comparison of selection pressure (dN/dS) on functional residues reveals some interesting insights into the evolution of the TF family including that the N-lobe of lactoferrin may be in the process of eliminating its iron binding function.	Iron	232-236	transferrin	Mus musculus	140-142
31493153-1	2019	The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for iron uptake at the plasma membrane, vacuolar iron transport, and mitochondrial iron metabolism, with the net result of mobilizing iron from extracellular sources and intracellular stores.	Iron	160-164	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	55-59
31493153-2	2019	Conversely, when iron levels are sufficient, Aft1 and Aft2 interact with the cytosolic glutaredoxins Grx3 and Grx4 and the BolA protein Bol2, which promote Aft1/2 dissociation from DNA and subsequent export from the nucleus.	Iron	17-21	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	45-49
31493153-2	2019	Conversely, when iron levels are sufficient, Aft1 and Aft2 interact with the cytosolic glutaredoxins Grx3 and Grx4 and the BolA protein Bol2, which promote Aft1/2 dissociation from DNA and subsequent export from the nucleus.	Iron	17-21	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	101-105
20547568-2	2010	Furthermore, the HTT gene has been functionally linked to iron (Fe) metabolism, and HD patients show alterations in brain and peripheral Fe homeostasis.	Iron	58-62	general transcription factor IIE subunit 1	Homo sapiens	64-66
31493153-2	2019	Conversely, when iron levels are sufficient, Aft1 and Aft2 interact with the cytosolic glutaredoxins Grx3 and Grx4 and the BolA protein Bol2, which promote Aft1/2 dissociation from DNA and subsequent export from the nucleus.	Iron	17-21	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	156-162
31493153-3	2019	Previous studies unveiled the molecular mechanism for iron-dependent inhibition of Aft1/2 activity, demonstrating that the [2Fe-2S]-bridged Grx3-Bol2 heterodimer transfers a cluster to Aft2, driving Aft2 dimerization and dissociation from DNA.	Iron	54-58	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	83-89
20579638-5	2010	Thus, OGFOD1 plays an important role in ischemic cell survival and an OGFOD1 iron binding residue is required for ATPAF1 gene expression.	Iron	77-81	ATP synthase mitochondrial F1 complex assembly factor 1	Homo sapiens	114-120
31493153-3	2019	Previous studies unveiled the molecular mechanism for iron-dependent inhibition of Aft1/2 activity, demonstrating that the [2Fe-2S]-bridged Grx3-Bol2 heterodimer transfers a cluster to Aft2, driving Aft2 dimerization and dissociation from DNA.	Iron	54-58	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	140-144
20504881-0	2010	Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury.	Iron	11-15	lipocalin 2	Homo sapiens	68-72
31493153-6	2019	Taken together, these results provide novel insight into the molecular details of iron-sulfur cluster transfer from Grx3-Bol2 to Aft2 which likely occurs through a ligand exchange mechanism.	Iron	82-86	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	116-120
20504881-12	2010	We conclude that 1) parenteral iron formulations that stimulate redox signaling can evoke cyto/nephrotoxicity; 2) secondary adaptive responses to this injury (e.g., HO-1/NGAL induction) can initiate a renal tubular cytoresistant state; this suggests a potential new clinical application for intravenous Fe therapy; and 3) FMX is bioneutral regarding these responses.	Iron	31-35	lipocalin 2	Homo sapiens	170-174
31493153-7	2019	Loss of either cysteine in the Aft2 iron-sulfur binding site may disrupt this ligand-exchange process leading to the isolation of a trapped Aft2-Grx3-Bol2 intermediate, while the replacement of both cysteines abrogates both the iron-sulfur cluster exchange and the protein-protein interactions between Aft2 and Grx3-Bol2.	Iron	36-40	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	145-149
20558581-7	2010	Iron supplementation caused suppression of endogenous duodenal SLC11A2 expression, down-regulation of duodenal ferroportin, and overexpression of hepatic hepcidin, precluding excessive iron uptake both in the TGs and wild-type mice.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	154-162
31493153-7	2019	Loss of either cysteine in the Aft2 iron-sulfur binding site may disrupt this ligand-exchange process leading to the isolation of a trapped Aft2-Grx3-Bol2 intermediate, while the replacement of both cysteines abrogates both the iron-sulfur cluster exchange and the protein-protein interactions between Aft2 and Grx3-Bol2.	Iron	36-40	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	311-315
20712796-0	2010	Hepcidin and Hfe in iron overload in beta-thalassemia.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	0-8
31442254-4	2019	Hfe-/- mice, a model of moderate iron overload, were reported to develop early liver fibrosis in response to a high fat diet.	Iron	33-37	homeostatic iron regulator	Mus musculus	0-3
20712796-0	2010	Hepcidin and Hfe in iron overload in beta-thalassemia.	Iron	20-24	homeostatic iron regulator	Mus musculus	13-16
20712796-1	2010	Hepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	0-8
20712796-1	2010	Hepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	10-14
20712796-1	2010	Hepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
20712796-1	2010	Hepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	10-14
20712796-4	2010	We also showed that the iron metabolism gene Hfe is down-regulated in concert with hepcidin in th3/+ mice.	Iron	24-28	homeostatic iron regulator	Mus musculus	45-48
20712796-4	2010	We also showed that the iron metabolism gene Hfe is down-regulated in concert with hepcidin in th3/+ mice.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	83-91
20712796-6	2010	Therefore, these studies suggest that increasing hepcidin and/or Hfe expression could be a strategy to reduces iron overload in these animals.	Iron	111-115	hepcidin antimicrobial peptide	Mus musculus	49-57
31442254-6	2019	These data raised the possibility that the Hfe gene may protect against liver injury independently of its iron regulatory function.	Iron	106-110	homeostatic iron regulator	Mus musculus	43-46
20712796-6	2010	Therefore, these studies suggest that increasing hepcidin and/or Hfe expression could be a strategy to reduces iron overload in these animals.	Iron	111-115	homeostatic iron regulator	Mus musculus	65-68
31434871-0	2019	Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer.	Iron	8-12	MDS1 and EVI1 complex locus	Homo sapiens	110-114
21125904-2	2010	The iron and Fe/Pd bimetal nanoparticles were prepared and used for removal of Cr6+ in waste water.	Iron	4-8	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	79-82
21125904-2	2010	The iron and Fe/Pd bimetal nanoparticles were prepared and used for removal of Cr6+ in waste water.	Iron	13-15	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	79-82
21125904-4	2010	The nanoparticles have higher efficiency than normal iron powders and Fe/Pd bimetallic nanoparticles show faster removal of the Cr6+ than iron nanoparticles.	Iron	70-72	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	128-131
31434871-8	2019	Collectively, our novel findings provide strong foundational evidence for potential iron-induced initiation events, including EVI1 alterations, in the pathogenesis of HGSOC, warranting further in depth investigations.	Iron	84-88	MDS1 and EVI1 complex locus	Homo sapiens	126-130
31287655-2	2019	We screened a set of clinically used iron chelators and report that they potently inhibit JMJD2A (KDM4A) in vitro.	Iron	37-41	lysine demethylase 4A	Homo sapiens	90-96
31412634-4	2019	Dietary restriction of zinc or intestinal specific conditional knock out of ZIP4 (SLC39A4), an intestinal zinc transporter, in experimental animals demonstrated iron deficiency anemia and tissue iron accumulation.	Iron	161-165	solute carrier family 39 member 4	Homo sapiens	76-80
20581821-0	2010	Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.	Iron	0-4	lipocalin 2	Homo sapiens	53-57
20581821-2	2010	Scn-Ngal (also known as neutrophil gelatinase associated lipocalin, siderocalin, lipocalin 2) sequesters bacterial iron chelators, called siderophores, and consequently blocks bacterial growth.	Iron	115-119	sorcin	Homo sapiens	0-3
31412634-4	2019	Dietary restriction of zinc or intestinal specific conditional knock out of ZIP4 (SLC39A4), an intestinal zinc transporter, in experimental animals demonstrated iron deficiency anemia and tissue iron accumulation.	Iron	161-165	solute carrier family 39 member 4	Homo sapiens	82-89
20581821-2	2010	Scn-Ngal (also known as neutrophil gelatinase associated lipocalin, siderocalin, lipocalin 2) sequesters bacterial iron chelators, called siderophores, and consequently blocks bacterial growth.	Iron	115-119	lipocalin 2	Homo sapiens	4-8
20581821-2	2010	Scn-Ngal (also known as neutrophil gelatinase associated lipocalin, siderocalin, lipocalin 2) sequesters bacterial iron chelators, called siderophores, and consequently blocks bacterial growth.	Iron	115-119	lipocalin 2	Homo sapiens	24-66
31375129-1	2019	Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation.	Iron	89-93	lipocalin 2	Homo sapiens	0-11
20581821-2	2010	Scn-Ngal (also known as neutrophil gelatinase associated lipocalin, siderocalin, lipocalin 2) sequesters bacterial iron chelators, called siderophores, and consequently blocks bacterial growth.	Iron	115-119	lipocalin 2	Homo sapiens	81-92
20581821-4	2010	Using chemical screens, crystallography and fluorescence methods, we report that Scn-Ngal binds iron together with a small metabolic product called catechol.	Iron	96-100	sorcin	Homo sapiens	81-84
20581821-4	2010	Using chemical screens, crystallography and fluorescence methods, we report that Scn-Ngal binds iron together with a small metabolic product called catechol.	Iron	96-100	lipocalin 2	Homo sapiens	85-89
20581821-6	2010	Scn-Ngal then recycled its iron in endosomes by a pH-sensitive mechanism.	Iron	27-31	sorcin	Homo sapiens	0-3
20581821-6	2010	Scn-Ngal then recycled its iron in endosomes by a pH-sensitive mechanism.	Iron	27-31	lipocalin 2	Homo sapiens	4-8
20681786-3	2010	In the absence of DNA-PKcs activity, less DSB repair and increased recruitment of RAD51 was seen at 24 h. After exposure to (56)Fe heavy ions, the number of cells with RAD51 tracks was less than the number of cells with gamma-H2AX at 24 h with both cell lines.	Iron	128-130	RAD51 recombinase	Homo sapiens	82-87
20681786-3	2010	In the absence of DNA-PKcs activity, less DSB repair and increased recruitment of RAD51 was seen at 24 h. After exposure to (56)Fe heavy ions, the number of cells with RAD51 tracks was less than the number of cells with gamma-H2AX at 24 h with both cell lines.	Iron	128-130	RAD51 recombinase	Homo sapiens	168-173
20867880-1	2010	We investigate the spin- and energy-dependent tunneling through a single organic molecule (CoPc) adsorbed on a ferromagnetic Fe thin film, spatially resolved by low-temperature spin-polarized scanning tunneling microscopy.	Iron	125-127	spindlin 1	Homo sapiens	19-23
31375129-1	2019	Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation.	Iron	89-93	lipocalin 2	Homo sapiens	13-17
31188032-9	2019	Iron accumulation in the kidneys of HFE knockout mice was associated with increase in serum and intrarenal renin expression.	Iron	0-4	homeostatic iron regulator	Mus musculus	36-39
31188032-10	2019	Induction of diabetes in HFE knockout mice using streptozotocin caused a much higher accumulation of renal iron and accelerated the progression of nephropathy compared with diabetic wild-type mice.	Iron	107-111	homeostatic iron regulator	Mus musculus	25-28
20540689-9	2010	In addition, the mRNA expression of hepcidin was also increased, suggesting blockage of iron recycling through FPN1 in spleen with cisplatin treatment.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	36-44
31062267-0	2019	A key gene bHLH115 in iron homeostasis: comprehensive bioinformatics analyses in Arabidopsis, tomato, rice, and maize.	Iron	22-26	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	11-18
20540689-11	2010	Hepcidin inhibits the function of FPN1 as iron-exporter leading to iron overloaded inside ferritins of splenic cells, which are stained with abnormal hemosiderin accumulation.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	0-8
20540689-11	2010	Hepcidin inhibits the function of FPN1 as iron-exporter leading to iron overloaded inside ferritins of splenic cells, which are stained with abnormal hemosiderin accumulation.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	0-8
31329045-8	2019	Among the proteins involved in iron metabolism, ferritin heavy chain (Fth), in charge of iron storage, appeared as the preferential target of fluoride according to quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry analyses.	Iron	31-35	ferritin heavy polypeptide 1	Mus musculus	48-68
20338170-1	2010	BACKGROUND &amp; AIMS: Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine.	Iron	142-146	homeostatic iron regulator	Mus musculus	93-96
31329045-8	2019	Among the proteins involved in iron metabolism, ferritin heavy chain (Fth), in charge of iron storage, appeared as the preferential target of fluoride according to quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry analyses.	Iron	31-35	ferritin heavy polypeptide 1	Mus musculus	70-73
31329045-8	2019	Among the proteins involved in iron metabolism, ferritin heavy chain (Fth), in charge of iron storage, appeared as the preferential target of fluoride according to quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry analyses.	Iron	89-93	ferritin heavy polypeptide 1	Mus musculus	48-68
31329045-8	2019	Among the proteins involved in iron metabolism, ferritin heavy chain (Fth), in charge of iron storage, appeared as the preferential target of fluoride according to quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry analyses.	Iron	89-93	ferritin heavy polypeptide 1	Mus musculus	70-73
20530571-0	2010	The yeast CLC protein counteracts vesicular acidification during iron starvation.	Iron	65-69	Gef1p	Saccharomyces cerevisiae S288C	10-13
20530571-4	2010	Gef1 localises to the late Golgi and prevacuole and is essential in conditions of iron limitation.	Iron	82-86	Gef1p	Saccharomyces cerevisiae S288C	0-4
31088860-7	2019	Loss of PRPF40B in K562 induces a KLF1 transcriptional signature, with genes involved in iron metabolism and mainly hypoxia, including related pathways like cholesterol biosynthesis and Akt/MAPK signaling.	Iron	89-93	pre-mRNA processing factor 40 homolog B	Homo sapiens	8-15
20530571-5	2010	In the absence of Gef1, a multicopper oxidase involved in iron uptake, Fet3, fails to acquire copper ion cofactors.	Iron	58-62	Gef1p	Saccharomyces cerevisiae S288C	18-22
20530571-7	2010	Here, we show that the Gef1-containing compartment is adjusted to a more alkaline pH under iron limitation.	Iron	91-95	Gef1p	Saccharomyces cerevisiae S288C	23-27
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	Iron	28-32	microRNA 374a	Homo sapiens	0-8
20310007-0	2010	ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation.	Iron	61-65	ATPase cation transporting 13A2	Homo sapiens	0-7
20310007-0	2010	ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation.	Iron	61-65	ATPase cation transporting 13A2	Homo sapiens	19-24
31349620-0	2019	Endohedral Fullerene Fe@C28 Adsorbed on Au(111) Surface as a High-Efficiency Spin Filter: A Theoretical Study.	Iron	21-23	spindlin 1	Homo sapiens	77-81
20495089-6	2010	In this article, we discuss the burgeoning field of mitochondrial iron metabolism and trafficking that has recently been stimulated by the discovery of proteins involved in mitochondrial iron storage (mitochondrial ferritin) and transport (mitoferrin-1 and -2).	Iron	66-70	solute carrier family 25 member 37	Homo sapiens	240-259
20495089-6	2010	In this article, we discuss the burgeoning field of mitochondrial iron metabolism and trafficking that has recently been stimulated by the discovery of proteins involved in mitochondrial iron storage (mitochondrial ferritin) and transport (mitoferrin-1 and -2).	Iron	187-191	solute carrier family 25 member 37	Homo sapiens	240-259
31349620-1	2019	We present a theoretical study on the adsorption and spin transport properties of magnetic Fe@C28 using Ab initio calculations based on spin density functional theory and non-equilibrium Green"s function techniques.	Iron	91-93	spindlin 1	Homo sapiens	53-57
31349620-1	2019	We present a theoretical study on the adsorption and spin transport properties of magnetic Fe@C28 using Ab initio calculations based on spin density functional theory and non-equilibrium Green"s function techniques.	Iron	91-93	spindlin 1	Homo sapiens	136-140
31349620-2	2019	Fe@C28 tends to adsorb on the bridge sites in the manner of C-C bonds, and the spin-resolved transmission spectra of Fe@C28 molecular junctions exhibit robust transport spin polarization (TSP).	Iron	0-2	spindlin 1	Homo sapiens	169-173
20481499-5	2010	In addition, we have found a correlation for substrate epoxidation reactions catalyzed by a range of heme and nonheme iron(IV)-oxo oxidants with the strength of the O-H bond in the iron-hydroxo complex, i.e. BDE(OH), which is supported by the VB model.	Iron	118-122	homeobox D13	Homo sapiens	208-211
31349620-2	2019	Fe@C28 tends to adsorb on the bridge sites in the manner of C-C bonds, and the spin-resolved transmission spectra of Fe@C28 molecular junctions exhibit robust transport spin polarization (TSP).	Iron	117-119	spindlin 1	Homo sapiens	79-83
20481499-5	2010	In addition, we have found a correlation for substrate epoxidation reactions catalyzed by a range of heme and nonheme iron(IV)-oxo oxidants with the strength of the O-H bond in the iron-hydroxo complex, i.e. BDE(OH), which is supported by the VB model.	Iron	181-185	homeobox D13	Homo sapiens	208-211
31349620-2	2019	Fe@C28 tends to adsorb on the bridge sites in the manner of C-C bonds, and the spin-resolved transmission spectra of Fe@C28 molecular junctions exhibit robust transport spin polarization (TSP).	Iron	117-119	spindlin 1	Homo sapiens	169-173
31349620-3	2019	Under small bias voltage, the transport properties of Fe@C28 are mainly determined by the spin-down channel and exhibit a large spin polarization.	Iron	54-56	spindlin 1	Homo sapiens	90-94
20215574-16	2010	In conclusion, iron depletion improved diabetic complications by inhibition of oxidative stress and TGFbeta signal pathways and the maintenance of pancreatic PPARbeta/delta and HIF-1alpha pathways.	Iron	15-19	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	177-187
31349620-3	2019	Under small bias voltage, the transport properties of Fe@C28 are mainly determined by the spin-down channel and exhibit a large spin polarization.	Iron	54-56	spindlin 1	Homo sapiens	128-132
31386535-0	2019	Femtosecond Laser-Excitation-Driven High Frequency Standing Spin Waves in Nanoscale Dielectric Thin Films of Iron Garnets.	Iron	109-113	spindlin 1	Homo sapiens	60-64
20633106-11	2010	Moreover, expression of heme oxygenase-1, alpha-synuclein aggregation, and DNA fragmentation were significantly enhanced in SN co-infused with low doses of arsenite and iron.	Iron	169-173	heme oxygenase 1	Rattus norvegicus	24-40
20633106-11	2010	Moreover, expression of heme oxygenase-1, alpha-synuclein aggregation, and DNA fragmentation were significantly enhanced in SN co-infused with low doses of arsenite and iron.	Iron	169-173	synuclein alpha	Rattus norvegicus	42-57
31187614-2	2019	Here, we report a metallic Fe (iron)-Au (gold) BNW-based platform for capturing CD8 T cells and the interferon-gamma (gamma) they secrete, both of which play key roles in controlling infectious diseases such as tuberculosis, at the single-cell level.	Iron	31-36	CD8a molecule	Homo sapiens	80-83
20347728-0	2010	Cu and Fe metallic ions-mediated oxidation of low-density lipoproteins studied by NMR, TEM and Z-scan technique.	Iron	7-9	MFT2	Homo sapiens	87-90
31071550-0	2019	The Growth Differentiation Factor-15 (GDF-15) levels are increased in patients with compound heterozygous sickle cell and beta-thalassemia (HbS/betathal), correlate with markers of hemolysis, iron burden, coagulation, endothelial dysfunction and pulmonary hypertension.	Iron	192-196	growth differentiation factor 15	Homo sapiens	4-36
20456487-0	2010	Hepcidin treatment in Hfe-/- mice diminishes plasma iron without affecting erythropoiesis.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	0-8
20456487-3	2010	Hepcidin is the main hormone that regulates iron homoestasis and it is secreted by the liver.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	0-8
20456487-4	2010	MATERIALS AND METHODS: We have studied how extended hepcidin administration affects the iron load status, plasma and tissue iron concentration, erythropoiesis and the expression of proteins involved on iron homeostasis in haemochromatotic (Hfe(-/-)) and wild-type mice.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	52-60
31071550-0	2019	The Growth Differentiation Factor-15 (GDF-15) levels are increased in patients with compound heterozygous sickle cell and beta-thalassemia (HbS/betathal), correlate with markers of hemolysis, iron burden, coagulation, endothelial dysfunction and pulmonary hypertension.	Iron	192-196	growth differentiation factor 15	Homo sapiens	38-44
20456487-4	2010	MATERIALS AND METHODS: We have studied how extended hepcidin administration affects the iron load status, plasma and tissue iron concentration, erythropoiesis and the expression of proteins involved on iron homeostasis in haemochromatotic (Hfe(-/-)) and wild-type mice.	Iron	124-128	hepcidin antimicrobial peptide	Mus musculus	52-60
20456487-4	2010	MATERIALS AND METHODS: We have studied how extended hepcidin administration affects the iron load status, plasma and tissue iron concentration, erythropoiesis and the expression of proteins involved on iron homeostasis in haemochromatotic (Hfe(-/-)) and wild-type mice.	Iron	124-128	hepcidin antimicrobial peptide	Mus musculus	52-60
31071550-4	2019	In this context we aimed to evaluate GDF-15 levels in 89 patients with HbS/betathal at steady phase and in 20 apparently healthy individuals, and correlate with clinical features of the disease and markers of hemolysis, iron burden, inflammation, coagulation and endothelial dysfunction.	Iron	220-224	growth differentiation factor 15	Homo sapiens	37-43
20456487-5	2010	RESULTS: Hepcidin reverted the high plasma iron concentrations in Hfe(-/-) mice to normal values.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	9-17
20456487-5	2010	RESULTS: Hepcidin reverted the high plasma iron concentrations in Hfe(-/-) mice to normal values.	Iron	43-47	homeostatic iron regulator	Mus musculus	66-69
31145704-9	2019	Importantly, FGF23 has emerged as a regulator of erythropoiesis, iron metabolism, and inflammation.	Iron	65-69	fibroblast growth factor 23	Homo sapiens	13-18
20456487-8	2010	These data confirm that hepcidin administration diminishes plasma iron concentrations.	Iron	66-70	hepcidin antimicrobial peptide	Mus musculus	24-32
20456487-9	2010	CONCLUSION: Treatment with sustained doses of hepcidin diminishes plasma iron concentrations in Hfe(-/-) mice.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	46-54
20175142-0	2010	Ferritin as a reporter gene for MRI: chronic liver over expression of H-ferritin during dietary iron supplementation and aging.	Iron	96-100	ferritin heavy polypeptide 1	Mus musculus	70-80
30963327-0	2019	Over-expression of Isu1p and Jac1p increases the ethanol tolerance and yield by superoxide and iron homeostasis mechanism in an engineered Saccharomyces cerevisiae yeast.	Iron	95-99	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	19-24
20363739-2	2010	Hepcidin is the key peptide hormone in iron homeostasis, and is secreted predominantly by hepatocytes.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	0-8
20363739-8	2010	Furthermore, iron depletion in Hjv(-/-) mice decreased hepatic BMP6 mRNA.	Iron	13-17	hemojuvelin BMP co-receptor	Mus musculus	31-34
30963327-0	2019	Over-expression of Isu1p and Jac1p increases the ethanol tolerance and yield by superoxide and iron homeostasis mechanism in an engineered Saccharomyces cerevisiae yeast.	Iron	95-99	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	29-34
20200349-3	2010	Both humans and mice with TMPRSS6 mutations show inappropriately elevated levels of the iron-regulatory hormone hepcidin, suggesting that TMPRSS6 acts to negatively regulate hepcidin expression.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	112-120
20200349-3	2010	Both humans and mice with TMPRSS6 mutations show inappropriately elevated levels of the iron-regulatory hormone hepcidin, suggesting that TMPRSS6 acts to negatively regulate hepcidin expression.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	174-182
30963327-2	2019	In Saccharomyces cerevisiae, the Jac1p and Isu1p proteins constitute the scaffold system for the Fe-S cluster assembly.	Iron	97-101	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	33-38
20200349-6	2010	In contrast, mice deficient for both Tmprss6 and hemojuvelin (Hjv), a BMP coreceptor that augments hepcidin expression in hepatocytes, showed markedly decreased hepatic levels of hepcidin and Id1 mRNA, markedly increased hepatic Bmp6 mRNA levels, and systemic iron overload similar to mice deficient for Hjv alone.	Iron	260-264	hemojuvelin BMP co-receptor	Mus musculus	49-60
20200349-6	2010	In contrast, mice deficient for both Tmprss6 and hemojuvelin (Hjv), a BMP coreceptor that augments hepcidin expression in hepatocytes, showed markedly decreased hepatic levels of hepcidin and Id1 mRNA, markedly increased hepatic Bmp6 mRNA levels, and systemic iron overload similar to mice deficient for Hjv alone.	Iron	260-264	hemojuvelin BMP co-receptor	Mus musculus	62-65
30963327-2	2019	In Saccharomyces cerevisiae, the Jac1p and Isu1p proteins constitute the scaffold system for the Fe-S cluster assembly.	Iron	97-101	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	43-48
30963327-3	2019	This study was performed using the over-expression of the Jac1p and Isu1p in the industrially utilized S. cerevisiae UMArn3 strain, with the objective of improving the Fe-S assembly/recycling, and thus counteracting the toxic effects of ethanol stress during fermentation.	Iron	168-172	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	58-63
20226494-6	2010	Results showed that at pH 8.2, freshly precipitated iron minerals transformed RDX, HMX, and TNT with reaction rates increasing with increasing Fe(II) concentrations.	Iron	52-56	radixin	Homo sapiens	78-81
30963327-3	2019	This study was performed using the over-expression of the Jac1p and Isu1p in the industrially utilized S. cerevisiae UMArn3 strain, with the objective of improving the Fe-S assembly/recycling, and thus counteracting the toxic effects of ethanol stress during fermentation.	Iron	168-172	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	68-73
31423419-10	2019	Factor 2 characterized by high loadings for carbohydrate, animal protein, fat, cholesterol, saturated fatty acid, sodium, biotin, copper, iron, fluoride, zinc, and calcium.	Iron	138-142	transcription termination factor 2	Homo sapiens	0-8
20348389-3	2010	In contrast, the mechanisms by which mammals couple the ferroxidase reaction to iron trafficking is unclear.	Iron	80-84	ferroxidase	Saccharomyces cerevisiae S288C	56-67
20348389-8	2010	Our analysis of FTR1 indicates its topology is similar to that of S. cerevisiae Ftr1p, with a potential exocytoplasmic iron channeling motif and two potential iron permeation motifs in membrane-spanning regions.	Iron	119-123	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	16-20
20348389-8	2010	Our analysis of FTR1 indicates its topology is similar to that of S. cerevisiae Ftr1p, with a potential exocytoplasmic iron channeling motif and two potential iron permeation motifs in membrane-spanning regions.	Iron	119-123	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	80-85
30914277-0	2019	Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes.	Iron	60-72	aquaporin 4	Mus musculus	81-92
20160020-3	2010	In this study, we determined that the Ybt system is required for the use of iron bound by transferrin and lactoferrin and examined the importance of the Ybt system for virulence in mouse models of bubonic and pneumonic plague.	Iron	76-80	transferrin	Mus musculus	90-101
30914277-3	2019	Previous study has shown that iron deposition could increase AQP4 expression, however, the mechanism of AQP4 expression upregulation after iron overload is still unclear.	Iron	30-34	aquaporin 4	Mus musculus	61-65
20445416-0	2010	Iron chelation therapy in Upper Egyptian transfusion-dependent pediatric homozygous beta-thalassemia major: impact on serum L-carnitine/free fatty acids, osteoprotegerin/the soluble receptor activator of nuclear factor-kappabeta ligand systems, and bone mineral density.	Iron	0-4	TNF superfamily member 11	Homo sapiens	182-235
30914277-3	2019	Previous study has shown that iron deposition could increase AQP4 expression, however, the mechanism of AQP4 expression upregulation after iron overload is still unclear.	Iron	139-143	aquaporin 4	Mus musculus	104-108
30914277-4	2019	In this study, we investigated the effect of ferrous iron overload on AQP4 expression in cultured mouse astrocytes.	Iron	45-57	aquaporin 4	Mus musculus	70-74
20404557-4	2010	We recently reported that UBC13, the only known ubiquitin conjugase capable of catalyzing Lys 63-linked polyubiqitination, is responsive to the iron (Fe) regime at the post-transcriptional level and may play a crucial role for the morphological alterations triggered by Fe deficiency in cucumber and Arabidopsis roots.	Iron	144-148	ubiquitin-conjugating enzyme E2 35-like	Cucumis sativus	26-31
30914277-7	2019	The role of oxidative stress and mitogen-activated protein kinases (MAPKs) signaling pathway in ferrous iron-induced AQP4 expression upregulation were further studied.	Iron	104-108	aquaporin 4	Mus musculus	117-121
20404557-4	2010	We recently reported that UBC13, the only known ubiquitin conjugase capable of catalyzing Lys 63-linked polyubiqitination, is responsive to the iron (Fe) regime at the post-transcriptional level and may play a crucial role for the morphological alterations triggered by Fe deficiency in cucumber and Arabidopsis roots.	Iron	150-152	ubiquitin-conjugating enzyme E2 35-like	Cucumis sativus	26-31
20404557-4	2010	We recently reported that UBC13, the only known ubiquitin conjugase capable of catalyzing Lys 63-linked polyubiqitination, is responsive to the iron (Fe) regime at the post-transcriptional level and may play a crucial role for the morphological alterations triggered by Fe deficiency in cucumber and Arabidopsis roots.	Iron	270-272	ubiquitin-conjugating enzyme E2 35-like	Cucumis sativus	26-31
30914277-8	2019	Ferrous iron exposure induced astrocyte death as well as cell swelling, and increased AQP4 expression.	Iron	0-12	aquaporin 4	Mus musculus	86-90
30914277-9	2019	AQP4 gene silencing after siRNA transfection attenuated ferrous iron-induced astrocyte death.	Iron	56-68	aquaporin 4	Mus musculus	0-4
30914277-11	2019	MAPKs were activated after ferrous iron treatment, and inhibitors of ERK and p38-MAPK relieved AQP4 expression upregulation as well as astrocyte death.	Iron	27-39	aquaporin 4	Mus musculus	95-99
30914277-12	2019	These results suggest that ferrous iron has distinctive toxic effects on cultured astrocytes and induces AQP4 expression upregulation.	Iron	27-39	aquaporin 4	Mus musculus	105-109
20177050-2	2010	Hepcidin is a key iron regulator, which is secreted by the liver, and decreases serum iron levels by causing the down-regulation of the iron transporter, ferroportin.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
20177050-2	2010	Hepcidin is a key iron regulator, which is secreted by the liver, and decreases serum iron levels by causing the down-regulation of the iron transporter, ferroportin.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	0-8
30914277-13	2019	MAPKs activation may play important roles in ferrous iron-induced astrocyte death through upregulation of AQP4 expression.	Iron	53-57	aquaporin 4	Mus musculus	106-110
20177050-5	2010	Expression of Hfe in Hfe-null mice both increased Hfe and hepcidin mRNA and lowered hepatic iron and Tf saturation.	Iron	92-96	homeostatic iron regulator	Mus musculus	14-17
30767226-2	2019	The iron chelator deferoxamine (DFO) has been widely used to enhance PpIX accumulation by inhibiting the iron-dependent bioconversion of PpIX to heme, a reaction catalyzed by ferrochelatase (FECH).	Iron	105-109	ferrochelatase	Homo sapiens	175-189
20177050-5	2010	Expression of Hfe in Hfe-null mice both increased Hfe and hepcidin mRNA and lowered hepatic iron and Tf saturation.	Iron	92-96	homeostatic iron regulator	Mus musculus	21-24
20177050-5	2010	Expression of Hfe in Hfe-null mice both increased Hfe and hepcidin mRNA and lowered hepatic iron and Tf saturation.	Iron	92-96	homeostatic iron regulator	Mus musculus	21-24
20177050-7	2010	Expression of Hfe in wild-type mice increased hepcidin mRNA and lowered iron levels.	Iron	72-76	homeostatic iron regulator	Mus musculus	14-17
20179178-3	2010	alpha-Tfr2 is the sensor of diferric transferrin, implicated in the modulation of hepcidin, the main regulator of iron homeostasis.	Iron	114-118	transferrin receptor 2	Mus musculus	6-10
20179178-3	2010	alpha-Tfr2 is the sensor of diferric transferrin, implicated in the modulation of hepcidin, the main regulator of iron homeostasis.	Iron	114-118	transferrin	Mus musculus	37-48
20179178-3	2010	alpha-Tfr2 is the sensor of diferric transferrin, implicated in the modulation of hepcidin, the main regulator of iron homeostasis.	Iron	114-118	hepcidin antimicrobial peptide	Mus musculus	82-90
20179178-6	2010	Adult Tfr2 KO mice show liver iron overload and inadequate hepcidin levels relative to body iron stores, even though they increase Bmp6 production.	Iron	30-34	transferrin receptor 2	Mus musculus	6-10
20179178-10	2010	Selective inactivation of liver alpha-Tfr2 in KI mice (LCKO-KI) returned the phenotype to liver iron overload.	Iron	96-100	transferrin receptor 2	Mus musculus	38-42
30767226-2	2019	The iron chelator deferoxamine (DFO) has been widely used to enhance PpIX accumulation by inhibiting the iron-dependent bioconversion of PpIX to heme, a reaction catalyzed by ferrochelatase (FECH).	Iron	105-109	ferrochelatase	Homo sapiens	191-195
20065295-2	2010	RGMc, also called hemojuvelin (HJV), is essential for iron homeostasis.	Iron	54-58	hemojuvelin BMP co-receptor	Mus musculus	0-4
31054940-4	2019	But the relationship between heme iron and SESN2, especially in the context of colon carcinogenesis, was not investigated previously.	Iron	34-38	sestrin 2	Mus musculus	43-48
20065295-2	2010	RGMc, also called hemojuvelin (HJV), is essential for iron homeostasis.	Iron	54-58	hemojuvelin BMP co-receptor	Mus musculus	18-29
20065295-2	2010	RGMc, also called hemojuvelin (HJV), is essential for iron homeostasis.	Iron	54-58	hemojuvelin BMP co-receptor	Mus musculus	31-34
31054940-8	2019	Although we formerly reported that SESN2 expression was reduced after p53 mutation in colon tumors, mouse colon tumors, which have intact p53 and NRF2, induced SESN2 expression in response to iron stimulus.	Iron	192-196	sestrin 2	Mus musculus	35-40
31054940-8	2019	Although we formerly reported that SESN2 expression was reduced after p53 mutation in colon tumors, mouse colon tumors, which have intact p53 and NRF2, induced SESN2 expression in response to iron stimulus.	Iron	192-196	sestrin 2	Mus musculus	160-165
20139087-1	2010	Deletion of two homologous genes, MRS3 and MRS4, that encode mitochondrial iron transporters affects the activity of the vacuolar iron importer Ccc1.	Iron	75-79	Ccc1p	Saccharomyces cerevisiae S288C	144-148
20139087-2	2010	Ccc1 levels are decreased in Deltamrs3Deltamrs4 cells, but the activity of the transporter is increased, resulting is reduced cytosolic iron.	Iron	136-140	Ccc1p	Saccharomyces cerevisiae S288C	0-4
31054940-10	2019	Taken together, although SESN2 generally suppresses tumorigenesis, it can produce tumor-promoting role in iron-rich environment by suppressing oxidative stress-associated cancer cell death.	Iron	106-110	sestrin 2	Mus musculus	25-30
20139087-3	2010	Overexpression of CCC1 in Deltamrs3Deltamrs4 cells results in a severe growth defect due to decreased cytosolic iron, referred to as the mitochondria-vacuole signaling (MVS) phenotype.	Iron	112-116	Ccc1p	Saccharomyces cerevisiae S288C	18-22
31244673-12	2019	ACTN3 polymorphism is associated with iron metabolism and hematological responses after endurance exercise.	Iron	38-42	actinin alpha 3	Homo sapiens	0-5
20123713-7	2010	Two mutants with the most extreme phenotype carry a transposon in a genomic region designated the NIF locus which encodes homologues of SufS and SufU, two proteins presumably involved in [Fe-S] cluster biosynthesis in Gram-positive bacteria.	Iron	188-190	S100 calcium binding protein A9	Homo sapiens	98-101
31159519-8	2019	Similarly,the protein levels as well as mRNA expression of IL-6 and IL-17 in patients with iron overload were significantly higher than those in non-iron overload group (P&lt;0.01 both in PB and BM).	Iron	91-95	interleukin 17A	Homo sapiens	68-73
19997898-3	2010	Using a conditional knockout mouse model where frataxin is deleted in the heart, it has been shown that this mutation leads to transferrin receptor-1 upregulation, resulting in increased iron uptake from transferrin.	Iron	187-191	frataxin	Mus musculus	47-55
19997898-3	2010	Using a conditional knockout mouse model where frataxin is deleted in the heart, it has been shown that this mutation leads to transferrin receptor-1 upregulation, resulting in increased iron uptake from transferrin.	Iron	187-191	transferrin	Mus musculus	127-138
31159519-9	2019	Conclusions: As hematopoietic regulators secreted by Th17 cells, the expression of IL-6 and IL-17 in MDS patients with iron overload are elevated.	Iron	119-123	interleukin 17A	Homo sapiens	92-97
30870640-3	2019	We report here for the first time, a low cost lab-on-a-screen-printed electrochemical cell (SPC) based on iron-sparked graphite working electrode modified with glucose oxidase (GOx) and glucose hydrogel droplets (GluHD) for the detection of flunitrazepam.	Iron	106-110	hydroxyacid oxidase 1	Homo sapiens	160-175
20181752-6	2010	In contrast, the regulation of the zinc transporters ZRT/IRT-LIKE PROTEIN2 (ZIP2), ZIP3, ZIP4, and ZIP9 was dependent on the cellular zinc level, and their regulation by Fe was a secondary effect.	Iron	170-172	ZRT/IRT-like protein 2	Arabidopsis thaliana	53-74
20181752-6	2010	In contrast, the regulation of the zinc transporters ZRT/IRT-LIKE PROTEIN2 (ZIP2), ZIP3, ZIP4, and ZIP9 was dependent on the cellular zinc level, and their regulation by Fe was a secondary effect.	Iron	170-172	ZRT/IRT-like protein 2	Arabidopsis thaliana	76-80
20181752-6	2010	In contrast, the regulation of the zinc transporters ZRT/IRT-LIKE PROTEIN2 (ZIP2), ZIP3, ZIP4, and ZIP9 was dependent on the cellular zinc level, and their regulation by Fe was a secondary effect.	Iron	170-172	zinc transporter	Arabidopsis thaliana	89-93
20181752-6	2010	In contrast, the regulation of the zinc transporters ZRT/IRT-LIKE PROTEIN2 (ZIP2), ZIP3, ZIP4, and ZIP9 was dependent on the cellular zinc level, and their regulation by Fe was a secondary effect.	Iron	170-172	ZIP metal ion transporter family	Arabidopsis thaliana	99-103
20181755-4	2010	AtNRAMP3 and AtNRAMP4 are required for iron mobilization in germinating seeds.	Iron	39-43	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	0-8
30870640-3	2019	We report here for the first time, a low cost lab-on-a-screen-printed electrochemical cell (SPC) based on iron-sparked graphite working electrode modified with glucose oxidase (GOx) and glucose hydrogel droplets (GluHD) for the detection of flunitrazepam.	Iron	106-110	hydroxyacid oxidase 1	Homo sapiens	177-180
20181755-4	2010	AtNRAMP3 and AtNRAMP4 are required for iron mobilization in germinating seeds.	Iron	39-43	natural resistance associated macrophage protein 4	Arabidopsis thaliana	13-21
30772592-9	2019	One of the reasons for the low promotion ability of Fe3+ in the whole pH range was the formation of Fe0 at pH less than 3.0, and the other was the weaker hydrolysis ability of Fe3+ itself at pH greater than 3.0.	Iron	100-103	l(2)FE3	Drosophila melanogaster	52-55
20113313-7	2010	CDJ3 and CDJ4 proteins could both be expressed in Escherichia coli and had redox-active Fe-S clusters.	Iron	88-92	uncharacterized protein	Chlamydomonas reinhardtii	9-13
20231891-6	2010	Transferrin Receptor 2 null mice are a model of type 3 hereditary hemochromatosis and develop significant iron overload providing increased iron stores at the onset of infection.	Iron	106-110	transferrin receptor 2	Mus musculus	0-22
20231891-6	2010	Transferrin Receptor 2 null mice are a model of type 3 hereditary hemochromatosis and develop significant iron overload providing increased iron stores at the onset of infection.	Iron	140-144	transferrin receptor 2	Mus musculus	0-22
20231891-8	2010	The response of the iron regulatory gene Hepcidin to infection and the changes in iron status were assessed by real-time PCR and Western blotting.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	41-49
20231891-9	2010	Our results show that Hepcidin levels responded to the changing iron status of the animals, but were not significantly influenced by the inflammatory response.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	22-30
20007457-3	2010	In rat duodenum, iron gavage resulted in the relocation of DMT1 to basal domains and the internalization of basolateral FPN.	Iron	17-21	RoBo-1	Rattus norvegicus	59-63
30370612-4	2019	It has been indicated that the regulation of FPN1 in response to the alteration of iron level mainly involves two processes, posttranscriptional repression by iron regulatory proteins (IRPs) and posttranslational degradation by hepcidin, the major iron-sensing hormone.	Iron	83-87	hepcidin antimicrobial peptide	Mus musculus	228-236
19861159-2	2010	Oxygen-dependency is maintained by prolyl- and asparagyl-4-hydroxylases (PHDs/FIH-1) belonging to the superfamily of iron(II) and 2-oxoglutarate dependent dioxygenases.	Iron	117-121	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	78-83
30370612-9	2019	Further investigation disclosed that the compromised hepcidin-FPN1 regulation in IRP2-/- cells was directly dependent on the existence of iron-responsive element (IRE) in FPN1 messenger RNA.	Iron	138-142	hepcidin antimicrobial peptide	Mus musculus	53-61
20125122-8	2010	Increased DMT1+IRE expression resulted in increased iron influx by MES23.5 cells.	Iron	52-56	RoBo-1	Rattus norvegicus	10-14
20125122-9	2010	Our data provide direct evidence that DMT1+IRE up-regulation can account for IRE/IRP-dependent 6-OHDA-induced iron accumulation initiated by 6-OHDA-induced intracellular oxidative stress and that increased levels of intracellular iron result in aggravated oxidative stress.	Iron	110-114	RoBo-1	Rattus norvegicus	38-42
30370612-9	2019	Further investigation disclosed that the compromised hepcidin-FPN1 regulation in IRP2-/- cells was directly dependent on the existence of iron-responsive element (IRE) in FPN1 messenger RNA.	Iron	138-142	iron responsive element binding protein 2	Mus musculus	81-85
20125122-9	2010	Our data provide direct evidence that DMT1+IRE up-regulation can account for IRE/IRP-dependent 6-OHDA-induced iron accumulation initiated by 6-OHDA-induced intracellular oxidative stress and that increased levels of intracellular iron result in aggravated oxidative stress.	Iron	230-234	RoBo-1	Rattus norvegicus	38-42
20125122-10	2010	The results of this study provide novel evidence supporting the use of anti-oxidants in the treatment of PD, with the goal of inhibiting iron accumulation by regulation of DMT1 expression.	Iron	137-141	RoBo-1	Rattus norvegicus	172-176
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	CD68 molecule	Homo sapiens	186-190
20008079-4	2010	As an example, the LEU1 gene of branched-chain amino acid biosynthesis is downregulated under iron-limiting conditions through depletion of the metabolic intermediate alpha-isopropylmalate, which functions as a key transcriptional coactivator of the Leu3 transcription factor.	Iron	94-98	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	19-23
20008079-4	2010	As an example, the LEU1 gene of branched-chain amino acid biosynthesis is downregulated under iron-limiting conditions through depletion of the metabolic intermediate alpha-isopropylmalate, which functions as a key transcriptional coactivator of the Leu3 transcription factor.	Iron	94-98	leucine-responsive transcriptional regulator LEU3	Saccharomyces cerevisiae S288C	250-254
19821111-6	2010	Furthermore, a severe down-regulation of ApoH was pointed out in iron-deficient animals.	Iron	65-69	apolipoprotein H	Rattus norvegicus	41-45
30835899-6	2019	Furthermore, iron loading of macrophages in the presence of IL-4 led to the down-regulation of M2 markers: arginase-1, Mgl-1, and M2-specific transcriptional regulator, KLF4.	Iron	13-17	LLGL scribble cell polarity complex component 1	Homo sapiens	119-124
30835899-6	2019	Furthermore, iron loading of macrophages in the presence of IL-4 led to the down-regulation of M2 markers: arginase-1, Mgl-1, and M2-specific transcriptional regulator, KLF4.	Iron	13-17	Kruppel like factor 4	Homo sapiens	169-173
19773263-1	2010	Hepcidin, a circulating regulatory hormone peptide produced by hepatocytes, functions as the master regulator of cellular iron export by controlling the amount of ferroportin, an iron exporter present on the basolateral surface of intestinal enterocytes and macrophages.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	0-8
31276102-0	2019	Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	81-89
19773263-1	2010	Hepcidin, a circulating regulatory hormone peptide produced by hepatocytes, functions as the master regulator of cellular iron export by controlling the amount of ferroportin, an iron exporter present on the basolateral surface of intestinal enterocytes and macrophages.	Iron	179-183	hepcidin antimicrobial peptide	Mus musculus	0-8
19773263-2	2010	Hepcidin binding to ferroportin induces its internalization and degradation, resulting in cellular iron retention and decreased iron export.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	0-8
19773263-2	2010	Hepcidin binding to ferroportin induces its internalization and degradation, resulting in cellular iron retention and decreased iron export.	Iron	128-132	hepcidin antimicrobial peptide	Mus musculus	0-8
31276102-2	2019	The Nrf2 transcription factor orchestrates cell-intrinsic protective antioxidant responses, and the peptide hormone hepcidin maintains systemic iron homeostasis, but is pathophysiologically decreased in haemochromatosis and beta-thalassaemia.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	116-124
31276102-3	2019	Here, we show that Nrf2 is activated by iron-induced, mitochondria-derived pro-oxidants and drives Bmp6 expression in liver sinusoid endothelial cells, which in turn increases hepcidin synthesis by neighbouring hepatocytes.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	176-184
31276102-4	2019	In Nrf2 knockout mice, the Bmp6-hepcidin response to oral and parenteral iron is impaired and iron accumulation and hepatic damage are increased.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	32-40
20121435-2	2010	The mammalian innate immunity protein lipocalin 2 (Lcn2; also known as neutrophil gelatinase-associated lipocalin, 24p3, or siderocalin) binds the siderophore carboxymycobactin, an essential component of the iron acquisition apparatus of mycobacteria.	Iron	208-212	lipocalin 2	Homo sapiens	38-49
20121435-2	2010	The mammalian innate immunity protein lipocalin 2 (Lcn2; also known as neutrophil gelatinase-associated lipocalin, 24p3, or siderocalin) binds the siderophore carboxymycobactin, an essential component of the iron acquisition apparatus of mycobacteria.	Iron	208-212	lipocalin 2	Homo sapiens	51-55
31276102-5	2019	Pharmacological activation of Nrf2 stimulates the Bmp6-hepcidin axis, improving iron homeostasis in haemochromatosis and counteracting the inhibition of Bmp6 by erythroferrone in beta-thalassaemia.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	55-63
20121435-2	2010	The mammalian innate immunity protein lipocalin 2 (Lcn2; also known as neutrophil gelatinase-associated lipocalin, 24p3, or siderocalin) binds the siderophore carboxymycobactin, an essential component of the iron acquisition apparatus of mycobacteria.	Iron	208-212	lipocalin 2	Homo sapiens	71-113
30828032-6	2019	Therefore, serum Fe concentration showed significant and negative correlation with SAA concentration (r2=0.500, P&lt;0.01).	Iron	17-19	serum amyloid A protein	Bos taurus	83-86
20228245-6	2010	Finally, we show that NRAMP1 restores the capacity of the iron-regulated transporter1 mutant to take up iron and cobalt, indicating that NRAMP1 has a broad selectivity in vivo.	Iron	58-62	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	22-28
20228245-6	2010	Finally, we show that NRAMP1 restores the capacity of the iron-regulated transporter1 mutant to take up iron and cobalt, indicating that NRAMP1 has a broad selectivity in vivo.	Iron	58-62	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	137-143
20228245-6	2010	Finally, we show that NRAMP1 restores the capacity of the iron-regulated transporter1 mutant to take up iron and cobalt, indicating that NRAMP1 has a broad selectivity in vivo.	Iron	104-108	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	22-28
20228245-6	2010	Finally, we show that NRAMP1 restores the capacity of the iron-regulated transporter1 mutant to take up iron and cobalt, indicating that NRAMP1 has a broad selectivity in vivo.	Iron	104-108	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	137-143
30947751-4	2019	We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of "free" or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD).	Iron	23-27	lipocalin 2	Homo sapiens	317-359
20117079-4	2010	We report here that FES interacts with KIT and is phosphorylated following activation by its ligand SCF.	Iron	20-23	KIT ligand	Homo sapiens	100-103
19969074-4	2010	To further explore the oxidative mechanism of aniline toxicity, we evaluated the potential contribution of heme oxygenase-1 (HO-1), which catalyzes heme degradation and releases free iron.	Iron	183-187	heme oxygenase 1	Rattus norvegicus	107-123
19969074-4	2010	To further explore the oxidative mechanism of aniline toxicity, we evaluated the potential contribution of heme oxygenase-1 (HO-1), which catalyzes heme degradation and releases free iron.	Iron	183-187	heme oxygenase 1	Rattus norvegicus	125-129
30947751-4	2019	We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of "free" or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD).	Iron	23-27	lipocalin 2	Homo sapiens	361-365
19969074-9	2010	The increase in HO-1 expression was associated with increases in total iron (2.4-and 2.7-fold), free iron (1.9-and 3.5-fold), and ferritin levels (1.9-and 2.1-fold) at 4 and 7 days of aniline exposure.	Iron	71-75	heme oxygenase 1	Rattus norvegicus	16-20
19969074-9	2010	The increase in HO-1 expression was associated with increases in total iron (2.4-and 2.7-fold), free iron (1.9-and 3.5-fold), and ferritin levels (1.9-and 2.1-fold) at 4 and 7 days of aniline exposure.	Iron	101-105	heme oxygenase 1	Rattus norvegicus	16-20
30947751-4	2019	We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of "free" or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD).	Iron	132-136	lipocalin 2	Homo sapiens	317-359
19969074-10	2010	Our data suggest that HO-1 up-regulation in aniline-induced splenic toxicity could be a contributing pro-oxidant mechanism, mediated through iron release, and leading to oxidative damage.	Iron	141-145	heme oxygenase 1	Rattus norvegicus	22-26
30947751-4	2019	We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of "free" or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD).	Iron	132-136	lipocalin 2	Homo sapiens	361-365
30947751-4	2019	We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of "free" or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD).	Iron	132-136	lipocalin 2	Homo sapiens	317-359
30947751-4	2019	We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of "free" or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD).	Iron	132-136	lipocalin 2	Homo sapiens	361-365
30610968-2	2019	Here, we found that the level of mTOR was increased both in wild-type mouse models with iron accumulation and transgenic mouse models (Hepc-/-) of high-turnover osteoporosis with iron accumulation.	Iron	179-183	hepcidin antimicrobial peptide	Mus musculus	135-139
19746426-7	2010	These data indicate that, in addition to the DMT1-mediated uptake of ferrous iron, astrocytes can accumulate ferric and ferrous iron by mechanisms that are independent of DMT1 or transferrin.	Iron	77-81	RoBo-1	Rattus norvegicus	45-49
30776642-4	2019	According to the role of iron manipulation in inflammatory process, we have synthetized RAc1 nano particle, which contains zinc and has iron chelating property.	Iron	25-29	Rac family small GTPase 1	Homo sapiens	88-92
20141512-4	2010	investigate the relationship between structure and function at the putative iron-binding site of Yfh1 (yeast frataxin).	Iron	76-80	ferroxidase	Saccharomyces cerevisiae S288C	97-101
20141512-5	2010	Using a host of Yfh1 combination point mutants, the authors observe that the presence of a semi-conserved pocket of negative charge within the "acidic ridge" region (thought to be responsible for iron binding) only mildly enhances Yfh1"s ability to bind iron, though it does significantly increase the protein"s structural flexibility.	Iron	254-258	ferroxidase	Saccharomyces cerevisiae S288C	231-235
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	14-18	growth differentiation factor 15	Homo sapiens	49-81
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	14-18	growth differentiation factor 15	Homo sapiens	83-88
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	193-197	growth differentiation factor 15	Homo sapiens	49-81
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	193-197	growth differentiation factor 15	Homo sapiens	83-88
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	193-197	growth differentiation factor 15	Homo sapiens	49-81
19863534-1	2010	Recently, the iron and erythropoiesis-controlled growth differentiation factor 15 (GDF15) has been shown to inhibit the expression of hepcidin in beta-thalassaemia patients, thereby increasing iron absorption despite iron overload.	Iron	193-197	growth differentiation factor 15	Homo sapiens	83-88
19863534-5	2010	IDA and ACD/IDA, but not ACD, showed an association between GDF15 and soluble transferrin receptor, an indicator of iron requirement for erythropoiesis.	Iron	116-120	growth differentiation factor 15	Homo sapiens	60-65
19863534-7	2010	While GDF15 levels were linked to the needs for erythropoiesis and iron homeostasis in IDA, the immunity-driven increase of GDF15 may not primarily affect iron homeostasis and hepcidin expression.	Iron	67-71	growth differentiation factor 15	Homo sapiens	6-11
30776642-4	2019	According to the role of iron manipulation in inflammatory process, we have synthetized RAc1 nano particle, which contains zinc and has iron chelating property.	Iron	136-140	Rac family small GTPase 1	Homo sapiens	88-92
30653415-7	2019	A greater protein expression level of endogenous thiol antioxidant thioredoxin (TRX) was observed among iron-loaded muscle whereas its endogenous inhibitor thioredoxin-interacting protein (TXNip) and the TRX/TXNip ratio were similar.	Iron	104-108	thioredoxin 1	Mus musculus	67-78
19540040-3	2010	For instance, acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans.	Iron	41-45	lipocalin 2	Homo sapiens	104-108
30653415-7	2019	A greater protein expression level of endogenous thiol antioxidant thioredoxin (TRX) was observed among iron-loaded muscle whereas its endogenous inhibitor thioredoxin-interacting protein (TXNip) and the TRX/TXNip ratio were similar.	Iron	104-108	thioredoxin 1	Mus musculus	80-83
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	148-156
19862562-7	2010	Also, Fe in CA3 and dentate gyrus, Cu in the parietal cortex, and Zn in CA3 and in the cortex were present at a higher level in the SNF group in comparison with the SNS group.	Iron	6-8	carbonic anhydrase 3	Rattus norvegicus	12-15
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	148-156
31002094-1	2019	Lactoferrin (LTF), also called lactotransferrin, is an iron-binding protein and member of transferrin family, whereas beta-LG is an important milk protein and belongs to the ligand-binding protein family of lipocalins and binds retinol.	Iron	55-59	inhibitor of carbonic anhydrase	Equus asinus	36-47
20091060-2	2010	Hepcidin, mainly produced by hepatocytes in a STAT3- and/or SMAD-dependent manner, is involved in iron homeostasis.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	0-8
20098432-2	2010	These complications are caused by labile plasma iron, which is taken up by parenchymal cells in a dysregulated manner; in contrast, erythropoiesis depends on transferrin-bound iron uptake via the transferrin receptor.	Iron	176-180	transferrin	Mus musculus	158-169
20098432-4	2010	We tested the ability of transferrin injections to modulate iron metabolism and erythropoiesis in Hbb(th1/th1) mice, an experimental model of beta-thalassemia.	Iron	60-64	transferrin	Mus musculus	25-36
30625433-0	2019	Magneto-optical properties of Au upon the injection of hot spin-polarized electrons across Fe/Au(0 0 1) interfaces.	Iron	91-93	alcohol dehydrogenase iron containing 1	Homo sapiens	55-58
20098432-6	2010	Specifically, transferrin injections normalized labile plasma iron concentrations, increased hepcidin expression, normalized red blood cell survival and increased hemoglobin production; this treatment concomitantly decreased reticulocytosis, erythropoietin abundance and splenomegaly.	Iron	62-66	transferrin	Mus musculus	14-25
30718286-5	2019	The A. baumannii genome invariably contains three tonB genes (tonB1, tonB2, and tonB3), whose role in iron uptake is poorly understood.	Iron	102-106	tonB dependent receptor	Acinetobacter baumannii	50-54
20371435-0	2010	Coexistence of HFE and rare UGT1A1 genes mutations in patients with iron overload related liver injury.	Iron	68-72	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	28-34
30967894-5	2019	NR2F6 and TGFB1 were identified and validated by motif discovery as key regulators of hepatic inflammatory response and muscle tissue development, respectively, two biological processes demonstrated to be associated with FE.	Iron	221-223	nuclear receptor subfamily 2 group F member 6	Bos taurus	0-5
19898775-0	2010	Role of hepcidin in murine brain iron metabolism.	Iron	33-37	hepcidin antimicrobial peptide	Mus musculus	8-16
19898775-2	2010	Hepcidin, an iron regulatory hormone produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia, has been shown to be the long-sought hormone responsible for the regulation of body iron balance and recycling in mammals.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	0-8
19898775-2	2010	Hepcidin, an iron regulatory hormone produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia, has been shown to be the long-sought hormone responsible for the regulation of body iron balance and recycling in mammals.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	0-8
30647129-1	2019	Iron efflux from mammalian cells is supported by the synergistic actions of the ferrous iron efflux transporter, ferroportin (Fpn) and a multicopper ferroxidase, that is, hephaestin (Heph), ceruloplasmin (Cp) or both.	Iron	0-4	hephaestin	Homo sapiens	171-181
19898775-6	2010	Additionally, treatment of primary cultured neurons with hepcidin caused decreased neuronal iron release and Fpn1 protein levels.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	57-65
19898775-7	2010	Together, our data provide further evidence that hepcidin may be involved in the regulation of brain iron metabolism.	Iron	101-105	hepcidin antimicrobial peptide	Mus musculus	49-57
30930742-1	2019	NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in intracellular and systemic iron homeostasis.	Iron	121-125	nuclear receptor coactivator 4	Homo sapiens	0-5
19234753-5	2010	The World Health Organization laundry staining Fe guideline of 0.3 mg/l was exceeded by 75% of surface water, 44% tap water, and 53% groundwater samples.	Iron	47-49	nuclear RNA export factor 1	Homo sapiens	114-117
20182641-2	2010	Here we describe FTR1, another iron regulated gene and mutational analysis of its promoter.	Iron	31-35	uncharacterized protein	Chlamydomonas reinhardtii	17-21
20182641-3	2010	Our results reveal that the FeREs of FTR1 distinguish itself from other iron response elements by containing both negative and positive regulatory regions.	Iron	72-76	uncharacterized protein	Chlamydomonas reinhardtii	37-41
20182641-4	2010	In FTR1, the -291/-236 region from the transcriptional start site is necessary and sufficient for Fe-deficiency-inducible expression.	Iron	98-100	uncharacterized protein	Chlamydomonas reinhardtii	3-7
30930742-1	2019	NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in intracellular and systemic iron homeostasis.	Iron	121-125	nuclear receptor coactivator 4	Homo sapiens	7-37
30930742-1	2019	NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in intracellular and systemic iron homeostasis.	Iron	205-209	nuclear receptor coactivator 4	Homo sapiens	0-5
20502037-11	2010	Taking into account the antimicrobial moieties of NGAL, further studies are needed to address the role of NGAL in iron metabolism and inflammation in renal failure.	Iron	114-118	lipocalin 2	Homo sapiens	106-110
30930742-1	2019	NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in intracellular and systemic iron homeostasis.	Iron	205-209	nuclear receptor coactivator 4	Homo sapiens	7-37
30930742-2	2019	Disruptions in iron homeostasis and autophagy are observed in several neurodegenerative disorders raising the possibility that NCOA4-mediated ferritinophagy links these two observations and may underlie, in part, the pathophysiology of neurodegeneration.	Iron	15-19	nuclear receptor coactivator 4	Homo sapiens	127-132
31061954-6	2019	Mechanistically, overexpression of adipose lipin-1 in mice facilitated the onset of hepatic ferroptosis, which is an iron-dependent form of cell death, and subsequently induced ferroptotic liver damage in mice under ethanol exposure.	Iron	117-121	lipin 1	Mus musculus	43-50
20306428-1	2010	Methemoglobinemia; an increased concentration of methemoglobin in the blood, is an altered state of hemoglobin whereby the ferrous form of iron is oxidized to the ferric state, rendering the heme moiety incapable of carrying oxygen.	Iron	139-143	hemoglobin subunit gamma 2	Homo sapiens	49-62
30700131-4	2019	This process was abrogated by iron via induction of H-ferritin as reflected by lowering ALP and osteocalcin secretion and preventing extracellular calcium deposition.	Iron	30-34	ATHS	Homo sapiens	88-91
21836226-2	2009	Spin and orbital contributions to magnetic moments, hyperfine fields and the Mossbauer isomer shifts at the Fe sites in Fe precipitates and Fe-Cu alloy clusters of sizes up to 60 Fe atoms embedded in the Cu matrix are calculated and the influence of the local environment on these properties is discussed.	Iron	108-110	spindlin 1	Homo sapiens	0-4
21836226-2	2009	Spin and orbital contributions to magnetic moments, hyperfine fields and the Mossbauer isomer shifts at the Fe sites in Fe precipitates and Fe-Cu alloy clusters of sizes up to 60 Fe atoms embedded in the Cu matrix are calculated and the influence of the local environment on these properties is discussed.	Iron	120-122	spindlin 1	Homo sapiens	0-4
21836226-2	2009	Spin and orbital contributions to magnetic moments, hyperfine fields and the Mossbauer isomer shifts at the Fe sites in Fe precipitates and Fe-Cu alloy clusters of sizes up to 60 Fe atoms embedded in the Cu matrix are calculated and the influence of the local environment on these properties is discussed.	Iron	120-122	spindlin 1	Homo sapiens	0-4
21836226-2	2009	Spin and orbital contributions to magnetic moments, hyperfine fields and the Mossbauer isomer shifts at the Fe sites in Fe precipitates and Fe-Cu alloy clusters of sizes up to 60 Fe atoms embedded in the Cu matrix are calculated and the influence of the local environment on these properties is discussed.	Iron	120-122	spindlin 1	Homo sapiens	0-4
30304704-6	2019	Following irradiation, reduced hepcidin activity of the liver contributed to elevated iron levels in the serum and liver.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	31-39
19767646-1	2009	Protoporphyrin IX ferrochelatase (EC 4.99.1.1) catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX.	Iron	126-138	ferrochelatase	Homo sapiens	18-32
19767646-1	2009	Protoporphyrin IX ferrochelatase (EC 4.99.1.1) catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX.	Iron	126-138	ferrochelatase	Homo sapiens	34-45
30304704-7	2019	By injecting hepcidin or deferoxamine (an iron chelator) to reduce iron level, deterioration of trabecular bone microarchitecture in irradiated mice was abrogated.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	13-21
30304704-7	2019	By injecting hepcidin or deferoxamine (an iron chelator) to reduce iron level, deterioration of trabecular bone microarchitecture in irradiated mice was abrogated.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	13-21
30776286-0	2019	Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic beta-cell dysfunction.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
19924247-11	2009	Higher smf-2 mRNA levels correlated with higher Fe content, supporting a role for SMF-2 in Fe uptake.	Iron	48-50	NRAMP-like transporter smf-2	Caenorhabditis elegans	7-12
30776286-3	2019	In this study, we focused on the role of low hepcidin level-induced increased iron deposition in beta-cells and the relationship between abnormal iron metabolism and beta-cell dysfunction.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	45-53
19924247-11	2009	Higher smf-2 mRNA levels correlated with higher Fe content, supporting a role for SMF-2 in Fe uptake.	Iron	91-93	NRAMP-like transporter smf-2	Caenorhabditis elegans	7-12
19924247-11	2009	Higher smf-2 mRNA levels correlated with higher Fe content, supporting a role for SMF-2 in Fe uptake.	Iron	91-93	NRAMP-like transporter smf-2	Caenorhabditis elegans	82-87
30776286-4	2019	Decreased hepcidin expression increased iron absorption by upregulating transferrin receptor 1 (TfR1) and divalent metal transporter 1 (DMT1) expression, resulting in iron accumulation within cells.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	10-18
19924283-0	2009	Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	91-99
19924283-1	2009	BACKGROUND: Hepcidin is a major regulator of iron metabolism and plays a key role in anemia of chronic disease, reducing intestinal iron uptake and release from body iron stores.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	12-20
30776286-4	2019	Decreased hepcidin expression increased iron absorption by upregulating transferrin receptor 1 (TfR1) and divalent metal transporter 1 (DMT1) expression, resulting in iron accumulation within cells.	Iron	167-171	hepcidin antimicrobial peptide	Mus musculus	10-18
19924283-1	2009	BACKGROUND: Hepcidin is a major regulator of iron metabolism and plays a key role in anemia of chronic disease, reducing intestinal iron uptake and release from body iron stores.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	12-20
30217775-4	2019	We present arguments favoring the enzymatic mechanisms of ferroptotically engaged non-heme iron of 15-lipoxygenases (15-LOX) in complexes with phosphatidylethanolamine binding protein 1 (PEBP1) as a catalyst of highly selective and specific oxidation reactions of arachidonoyl- (AA) and adrenoyl-phosphatidylethanolamines (PE).	Iron	91-95	phosphatidylethanolamine binding protein 1	Homo sapiens	143-185
19924283-1	2009	BACKGROUND: Hepcidin is a major regulator of iron metabolism and plays a key role in anemia of chronic disease, reducing intestinal iron uptake and release from body iron stores.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	12-20
19924283-4	2009	METHODOLOGY/PRINCIPAL FINDINGS: Hepcidin mRNA was down-regulated in hepatoma cells by chemical HIF stabilizers and iron chelators, respectively.	Iron	115-119	hepcidin antimicrobial peptide	Mus musculus	32-40
19924283-8	2009	Hepcidin expression was also markedly and rapidly decreased by serum deprivation, independent of transferrin-bound iron, and by the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, indicating that growth factors are required for hepcidin expression in vitro.	Iron	115-119	hepcidin antimicrobial peptide	Mus musculus	0-8
30217775-4	2019	We present arguments favoring the enzymatic mechanisms of ferroptotically engaged non-heme iron of 15-lipoxygenases (15-LOX) in complexes with phosphatidylethanolamine binding protein 1 (PEBP1) as a catalyst of highly selective and specific oxidation reactions of arachidonoyl- (AA) and adrenoyl-phosphatidylethanolamines (PE).	Iron	91-95	phosphatidylethanolamine binding protein 1	Homo sapiens	187-192
30266734-0	2019	Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	85-93
19831361-1	2009	We describe the multistep synthesis of a new terthienyl-substituted QsalH ligand and an iron(3+) spin-crossover complex (1) containing this ligand, which electropolymerizes to produce a hybrid-conducting metallopolymer film (poly1).	Iron	88-92	spindlin 1	Homo sapiens	97-101
29909454-11	2019	OGDR and iron reduced the cell viability and increased the expression of TLR-4 associated proteins (RIP3, MyD88, phospho-NF-kB, and release of IL-6) in BMVECs from diabetic animals.	Iron	9-13	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	100-104
19809161-8	2009	Our data suggest that low intracellular iron selectively impairs signaling via the TLR4/TRAM/TRIF pathway proximal to TRIF and results in reduced LPS-induced cytokine expression.	Iron	40-44	toll-like receptor adaptor molecule 2	Mus musculus	88-92
19809161-8	2009	Our data suggest that low intracellular iron selectively impairs signaling via the TLR4/TRAM/TRIF pathway proximal to TRIF and results in reduced LPS-induced cytokine expression.	Iron	40-44	toll-like receptor adaptor molecule 2	Mus musculus	93-97
19809161-8	2009	Our data suggest that low intracellular iron selectively impairs signaling via the TLR4/TRAM/TRIF pathway proximal to TRIF and results in reduced LPS-induced cytokine expression.	Iron	40-44	toll-like receptor adaptor molecule 2	Mus musculus	118-122
19809161-9	2009	Furthermore, by mimicking the altered iron metabolism associated with Hfe deficiency, we found that 3 different inhibitors of hepcidin attenuated Salmonella-induced and noninfectious enterocolitis.	Iron	38-42	homeostatic iron regulator	Mus musculus	70-73
19809161-9	2009	Furthermore, by mimicking the altered iron metabolism associated with Hfe deficiency, we found that 3 different inhibitors of hepcidin attenuated Salmonella-induced and noninfectious enterocolitis.	Iron	38-42	hepcidin antimicrobial peptide	Mus musculus	126-134
30517741-6	2019	In addition, the PIH-mediated downregulation of human FECH is associated with iron chelation.	Iron	78-82	ferrochelatase	Homo sapiens	54-58
19652026-1	2009	Hepcidin is an antimicrobial peptide involved in regulating iron homeostasis.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	0-8
19652026-3	2009	Hepcidin regulates iron metabolism by inhibiting iron absorption by the duodenum and by inhibiting macrophage iron recycling.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	0-8
19652026-3	2009	Hepcidin regulates iron metabolism by inhibiting iron absorption by the duodenum and by inhibiting macrophage iron recycling.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	0-8
30478858-0	2019	Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	48-56
19652026-3	2009	Hepcidin regulates iron metabolism by inhibiting iron absorption by the duodenum and by inhibiting macrophage iron recycling.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	0-8
19764800-1	2009	The recombinant diheme cytochrome c(4) from the psycrophilic bacterium Pseudoalteromonas haloplanktis TAC 125 and its Met64Ala and Met164Ala variants, which feature a hydroxide ion axially bound to the heme iron at the N- and C-terminal domains, respectively, were found to exchange electrons efficiently with a gold electrode coated with a SAM of 11-mercapto-1-undecanoic acid.	Iron	207-211	PSHA_RS13535	Pseudoalteromonas haloplanktis TAC125	23-35
30478858-1	2019	The bone morphogenetic protein (BMP)-SMAD signaling pathway is a key transcriptional regulator of hepcidin in response to tissue iron stores, serum iron, erythropoietic drive and inflammation to increase the iron supply when needed for erythropoiesis, but to prevent the toxicity of iron excess.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	98-106
30478858-1	2019	The bone morphogenetic protein (BMP)-SMAD signaling pathway is a key transcriptional regulator of hepcidin in response to tissue iron stores, serum iron, erythropoietic drive and inflammation to increase the iron supply when needed for erythropoiesis, but to prevent the toxicity of iron excess.	Iron	148-152	hepcidin antimicrobial peptide	Mus musculus	98-106
30478858-1	2019	The bone morphogenetic protein (BMP)-SMAD signaling pathway is a key transcriptional regulator of hepcidin in response to tissue iron stores, serum iron, erythropoietic drive and inflammation to increase the iron supply when needed for erythropoiesis, but to prevent the toxicity of iron excess.	Iron	148-152	hepcidin antimicrobial peptide	Mus musculus	98-106
19715344-1	2009	The transcription of iron uptake and storage genes in Saccharomyces cerevisiae is primarily regulated by the transcription factor Aft1.	Iron	21-25	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	130-134
19715344-2	2009	Nucleocytoplasmic shuttling of Aft1 is dependent upon mitochondrial Fe-S cluster biosynthesis via a signaling pathway that includes the cytosolic monothiol glutaredoxins (Grx3 and Grx4) and the BolA homologue Fra2.	Iron	68-70	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	31-35
30478858-1	2019	The bone morphogenetic protein (BMP)-SMAD signaling pathway is a key transcriptional regulator of hepcidin in response to tissue iron stores, serum iron, erythropoietic drive and inflammation to increase the iron supply when needed for erythropoiesis, but to prevent the toxicity of iron excess.	Iron	148-152	hepcidin antimicrobial peptide	Mus musculus	98-106
30478858-7	2019	However, hepcidin was still induced by both iron loading methods in Bmp2 CKO mice, although the degree of hepcidin induction was blunted relative to control mice.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	9-17
30478858-9	2019	Thus, BMP2 has at least a partially redundant role in hepcidin regulation by serum iron, tissue iron, inflammation and erythropoietic drive.	Iron	83-87	hepcidin antimicrobial peptide	Mus musculus	54-62
30478858-10	2019	In contrast, BMP6 is absolutely required for hepcidin regulation by serum iron.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	45-53
19691493-8	2009	When mouse erythroleukemia cells were treated with 12-O-tetradecanoyl-phorbol 13-acetate, an activator of protein kinase C, or hemin, phospho-ferrochelatase levels increased, with a concomitant decrease in zinc-insertion activity and a slight increase in iron-removal activity.	Iron	255-259	ferrochelatase	Mus musculus	142-156
19785692-0	2009	Forward genetics used to identify new gene Mon1a with critical role in controlling macrophage iron metabolism and iron recycling from erythrocytes.	Iron	94-98	MON1 homolog A, secretory traffciking associated	Mus musculus	43-48
29948914-0	2019	Iron Accumulation Leads to Bone Loss by Inducing Mesenchymal Stem Cell Apoptosis Through the Activation of Caspase3.	Iron	0-4	caspase 3	Mus musculus	107-115
19785692-0	2009	Forward genetics used to identify new gene Mon1a with critical role in controlling macrophage iron metabolism and iron recycling from erythrocytes.	Iron	114-118	MON1 homolog A, secretory traffciking associated	Mus musculus	43-48
19785692-3	2009	Additional approaches to narrow the genomic region identified the gene Mon1a, which codes for a protein that acts as a novel regulator of spleen iron release.	Iron	145-149	MON1 homolog A, secretory traffciking associated	Mus musculus	71-76
19785692-4	2009	Cell-based studies showed that Mon1a is necessary for vesicular trafficking of proteins, including the iron-export protein ferroportin, to the macrophage cell membrane.	Iron	103-107	MON1 homolog A, secretory traffciking associated	Mus musculus	31-36
19622835-1	2009	Impaired regulation of hepcidin expression in response to iron loading appears to be the pathogenic mechanism for hereditary hemochromatosis.	Iron	58-62	hepcidin antimicrobial peptide	Mus musculus	23-31
19622835-2	2009	Iron normally induces expression of the BMP6 ligand, which, in turn, activates the BMP/Smad signaling cascade directing hepcidin expression.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	120-128
29948914-12	2019	MSC apoptosis was increased, and more caspase3 was cleaved after iron intervention.	Iron	65-69	caspase 3	Mus musculus	38-46
30393904-6	2019	Nurses and physicians were instructed to fill out an HSR registration form with every administration of intravenous iron.	Iron	116-120	HSR	Homo sapiens	53-56
19580816-10	2009	The structural and biophysical results are discussed in relation to possible roles of Miner1 in cellular Fe-S management and redox reactions.	Iron	105-109	CDGSH iron sulfur domain 2	Homo sapiens	86-92
30277817-2	2019	While mutation in the hemochromatosis ( HFE) gene disrupts iron homeostasis and promotes oxidative stress that increases the risk of neurodegeneration, it is largely unknown whether HFE mutation modifies GABAergic homeostasis and emotional behavior.	Iron	59-63	homeostatic iron regulator	Mus musculus	40-43
19877527-7	2009	CONCLUSION: vitamin A deficiency can change cellular iron metabolism by inducing IRP2-Fn-TFR pathway.	Iron	53-57	iron responsive element binding protein 2	Rattus norvegicus	81-85
19877527-9	2009	Taken together, these results indicate that vitamin A deficiency can regulate iron metabolism by IRP2-TFR-Fn pathway.	Iron	78-82	iron responsive element binding protein 2	Rattus norvegicus	97-101
30277817-9	2019	Taken together, our results suggest a putative role of HFE in regulating labile iron status in the brain, and mutation in H67D perturbs redox-methylation status, contributing to GABAergic dysfunction.-Ye, Q., Trivedi, M., Zhang, Y., Bohlke, M., Alsulimani, H., Chang, J., Maher, T., Deth, R., Kim, J.	Iron	80-84	homeostatic iron regulator	Mus musculus	55-58
30468967-4	2019	Using CNF-Ox as a support led to a large extent and irreversible attachment of iron nanoparticle compared to a lower extent and reversible attachment of Fe-NPs to pristine CNF, indicating the influence of surface functionalization on colloidal particle attachment.	Iron	79-83	NPHS1 adhesion molecule, nephrin	Homo sapiens	6-9
19561359-1	2009	Superoxide dismutase 2 (SOD2) is one of the rare mitochondrial enzymes evolved to use manganese as a cofactor over the more abundant element iron.	Iron	141-145	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	0-22
19561359-1	2009	Superoxide dismutase 2 (SOD2) is one of the rare mitochondrial enzymes evolved to use manganese as a cofactor over the more abundant element iron.	Iron	141-145	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	24-28
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	112-117
19561359-2	2009	Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.	Iron	57-61	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	112-117
19561359-5	2009	Instead, small changes in mitochondrial iron are likely to promote iron-SOD2 interactions.	Iron	40-44	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	72-76
30692693-3	2019	Overexpression of the Arabidopsis thaliana vacuolar iron transporter VIT1 in cassava accumulated three- to seven-times-higher levels of iron in transgenic storage roots than nontransgenic controls in confined field trials in Puerto Rico.	Iron	52-56	vacuolar iron transporter 1	Arabidopsis thaliana	69-73
19561359-5	2009	Instead, small changes in mitochondrial iron are likely to promote iron-SOD2 interactions.	Iron	67-71	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	72-76
19561359-6	2009	Iron binds Sod2p in yeast mutants blocking late stages of iron-sulfur cluster biogenesis (grx5, ssq1, and atm1), but not in mutants defective in the upstream Isu proteins that serve as scaffolds for iron-sulfur biosynthesis.	Iron	0-4	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	11-16
19561359-6	2009	Iron binds Sod2p in yeast mutants blocking late stages of iron-sulfur cluster biogenesis (grx5, ssq1, and atm1), but not in mutants defective in the upstream Isu proteins that serve as scaffolds for iron-sulfur biosynthesis.	Iron	58-62	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	11-16
30692693-4	2019	Plants engineered to coexpress a mutated A. thaliana iron transporter (IRT1) and A. thaliana ferritin (FER1) accumulated iron levels 7-18 times higher and zinc levels 3-10 times higher than those in nontransgenic controls in the field.	Iron	53-57	iron-regulated transporter 1	Arabidopsis thaliana	71-75
30692693-6	2019	Measures of retention and bioaccessibility of iron and zinc in processed transgenic cassava indicated that IRT1 + FER1 plants could provide 40-50% of the EAR for iron and 60-70% of the EAR for zinc in 1- to 6-year-old children and nonlactating, nonpregnant West African women.	Iron	46-50	iron-regulated transporter 1	Arabidopsis thaliana	107-111
19491103-7	2009	Our observations challenge the view that iron delivery for ISC synthesis is mediated by Fe2+-loaded monomeric Yfh1.	Iron	41-45	ferroxidase	Saccharomyces cerevisiae S288C	110-114
30692693-6	2019	Measures of retention and bioaccessibility of iron and zinc in processed transgenic cassava indicated that IRT1 + FER1 plants could provide 40-50% of the EAR for iron and 60-70% of the EAR for zinc in 1- to 6-year-old children and nonlactating, nonpregnant West African women.	Iron	162-166	iron-regulated transporter 1	Arabidopsis thaliana	107-111
19491103-8	2009	Rather, we find that the iron oxidation-driven oligomerization of Yfh1 promotes the assembly of stable multicomponent complexes in which the iron donor and the sulfur donor simultaneously interact with each other as well as with the scaffold.	Iron	25-29	ferroxidase	Saccharomyces cerevisiae S288C	66-70
19491103-8	2009	Rather, we find that the iron oxidation-driven oligomerization of Yfh1 promotes the assembly of stable multicomponent complexes in which the iron donor and the sulfur donor simultaneously interact with each other as well as with the scaffold.	Iron	141-145	ferroxidase	Saccharomyces cerevisiae S288C	66-70
19491103-9	2009	Moreover, the ability to store ferric iron enables oligomeric Yfh1 to adjust iron release depending on the presence of Isu1 and the availability of elemental sulfur and reducing equivalents.	Iron	38-42	ferroxidase	Saccharomyces cerevisiae S288C	62-66
30701192-8	2019	IMPORTANCE The impact of the FE-associated differences in feed intake on intestinal bacterial and host physiological parameters has so far not been clarified.	Iron	29-31	FI	Gallus gallus	58-69
19520626-8	2009	The value of CHr was below 25 pg in the diagnostic groups with iron deficiency and iron deficiency anaemia, and above this value in the diagnostic groups with non-iron deficient anaemia or normal.	Iron	63-67	chromate resistance; sulfate transport	Homo sapiens	13-16
19520628-9	2009	CONCLUSIONS: Our study indicates that the measurement of CHr may be a reliable method to assess deficiencies in tissue iron supply.	Iron	119-123	chromate resistance; sulfate transport	Homo sapiens	57-60
30623799-6	2019	NRP1 loss reduces ABCB8 levels, resulting in iron accumulation, iron-induced mitochondrial superoxide production, and iron-dependent EC senescence.	Iron	45-49	ATP binding cassette subfamily B member 8	Homo sapiens	18-23
19469713-1	2009	Aft1 is a transcriptional activator in Saccharomyces cerevisiae that responds to iron availability and regulates the expression of genes in the iron regulon, such as FET3, FTR1 and the ARN family.	Iron	81-85	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
19469713-1	2009	Aft1 is a transcriptional activator in Saccharomyces cerevisiae that responds to iron availability and regulates the expression of genes in the iron regulon, such as FET3, FTR1 and the ARN family.	Iron	144-148	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
19469713-1	2009	Aft1 is a transcriptional activator in Saccharomyces cerevisiae that responds to iron availability and regulates the expression of genes in the iron regulon, such as FET3, FTR1 and the ARN family.	Iron	144-148	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	172-176
30623799-6	2019	NRP1 loss reduces ABCB8 levels, resulting in iron accumulation, iron-induced mitochondrial superoxide production, and iron-dependent EC senescence.	Iron	64-68	ATP binding cassette subfamily B member 8	Homo sapiens	18-23
30623799-6	2019	NRP1 loss reduces ABCB8 levels, resulting in iron accumulation, iron-induced mitochondrial superoxide production, and iron-dependent EC senescence.	Iron	64-68	ATP binding cassette subfamily B member 8	Homo sapiens	18-23
30678075-2	2019	A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) that cause the following five diseases: (1) hereditary hyperferritinemia with cataract syndrome (HHCS), (2) neuroferritinopathy, a subtype of neurodegeneration with brain iron accumulation (NBIA), (3) benign hyperferritinemia, (4) L-ferritin deficiency with autosomal dominant inheritance, and (5) L-ferritin deficiency with autosomal recessive inheritance.	Iron	255-259	ferritin light chain	Homo sapiens	74-77
19531652-0	2009	Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition.	Iron	30-34	ferritin heavy polypeptide 1	Mus musculus	0-20
19531652-5	2009	In response to TGF-beta1, there was a dramatic decrease in the FHC levels, which caused iron release from FHC and, therefore, increased the intracellular labile iron pool (LIP).	Iron	88-92	ferritin heavy polypeptide 1	Mus musculus	63-66
19531652-5	2009	In response to TGF-beta1, there was a dramatic decrease in the FHC levels, which caused iron release from FHC and, therefore, increased the intracellular labile iron pool (LIP).	Iron	88-92	ferritin heavy polypeptide 1	Mus musculus	106-109
19531652-5	2009	In response to TGF-beta1, there was a dramatic decrease in the FHC levels, which caused iron release from FHC and, therefore, increased the intracellular labile iron pool (LIP).	Iron	161-165	ferritin heavy polypeptide 1	Mus musculus	63-66
19531652-12	2009	Our data show that cellular iron homeostasis regulated by FHC plays a critical role in TGF-beta1-induced EMT.	Iron	28-32	ferritin heavy polypeptide 1	Mus musculus	58-61
30761254-4	2019	Our results indicated that both iron-bound transferrin (holo-Tf) and the small-molecule iron transporter hinokitiol with iron ions (hinokitiol plus iron) promote hemoglobin synthesis and the enucleation of mouse spleen-derived erythroblasts.	Iron	32-36	transferrin	Mus musculus	43-54
30970366-3	2019	Perturbations in iron availability form the primary basis for anemia in many patients with cancer-related anemia.	Iron	17-21	myotubularin related protein 11	Homo sapiens	91-112
20428459-8	2009	Besides EPR spectra of ferric mononuclear sites, EPR of ferrous iron coupled to a spin 1/2 radical, as it pertains to the categories mononuclear and non-heme, will also be covered, in the second half of this chapter.	Iron	64-68	spindlin 1	Homo sapiens	82-90
30252570-0	2019	Mitochondrial quality control mediated by PINK1 and PRKN: links to iron metabolism and tumor immunity.	Iron	67-71	parkin RBR E3 ubiquitin protein ligase	Mus musculus	52-56
19348938-0	2009	Iron speciation study in Hfe knockout mice tissues: magnetic and ultrastructural characterisation.	Iron	0-4	homeostatic iron regulator	Mus musculus	25-28
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	82-86	parkin RBR E3 ubiquitin protein ligase	Mus musculus	28-32
19366614-3	2009	The ubiquinone reduction site close to iron-sulfur cluster N2 at the interface of the 49-kDa and PSST subunits has been mapped by extensive site directed mutagenesis.	Iron	39-43	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	97-101
30252570-4	2019	Mechanistically, PINK1- and PRKN-mediated autophagic degradation of mitochondrial iron importers (e.g., SLC25A37 and SLC25A28) suppresses pancreatic tumor growth by attenuating mitochondrial iron accumulation, inflammasome activation, HMGB1 release, and subsequent immune checkpoint expression.	Iron	191-195	parkin RBR E3 ubiquitin protein ligase	Mus musculus	28-32
30943476-0	2019	Differential Impacts of Intravenous Iron Administration and Iron-Containing Phosphate Binders on Serum Intact Fibroblast Growth Factor 23 Levels.	Iron	36-40	fibroblast growth factor 23	Homo sapiens	110-137
19213835-4	2009	Intraperitoneal administration of lipopolysaccharide (LPS) in mice triggers a transient transcription of the gene encoding for hepcidin, a key regulator of iron homeostasis, in the choroid plexus, which correlated with increased detection of pro-hepcidin in the CSF.	Iron	156-160	hepcidin antimicrobial peptide	Mus musculus	127-135
19454495-1	2009	BACKGROUND: The circulating hormone hepcidin plays a central role in iron homeostasis.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	36-44
19454495-2	2009	Our goal was to establish an ex vivo iron-sensing model and to characterize the molecular mechanisms linking iron to hepcidin.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	117-125
19454495-2	2009	Our goal was to establish an ex vivo iron-sensing model and to characterize the molecular mechanisms linking iron to hepcidin.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	117-125
19454495-11	2009	CONCLUSIONS: We demonstrate that hepatocytes are liver iron-sensor cells and that transferrin receptor-2, by signaling through the ERK1/2 pathway, and bone morphogenetic protein/hemojuvelin, by signaling through the Smad pathways, coordinately regulate the iron-sensing machinery linking holotransferrin to hepcidin.	Iron	257-261	transferrin receptor 2	Mus musculus	82-104
30943476-0	2019	Differential Impacts of Intravenous Iron Administration and Iron-Containing Phosphate Binders on Serum Intact Fibroblast Growth Factor 23 Levels.	Iron	60-64	fibroblast growth factor 23	Homo sapiens	110-137
30943476-1	2019	AIMS: This study assessed the impact of iron administration on serum fibroblast growth factor 23 (FGF23) levels.	Iron	40-44	fibroblast growth factor 23	Homo sapiens	69-96
30943476-1	2019	AIMS: This study assessed the impact of iron administration on serum fibroblast growth factor 23 (FGF23) levels.	Iron	40-44	fibroblast growth factor 23	Homo sapiens	98-103
30943476-6	2019	However, intact FGF23 levels were continuously higher in the intravenous iron group than those in the other groups.	Iron	73-77	fibroblast growth factor 23	Homo sapiens	16-21
30943476-7	2019	CONCLUSION: Intravenous iron administration may influence intact FGF23 levels in HD patients independently of phosphate and iron metabolism.	Iron	24-28	fibroblast growth factor 23	Homo sapiens	65-70
30943480-2	2019	The reticulocyte hemoglobin content (CHr) is believed to reflect the concentration of iron required in the most recent hematopoiesis in the bone marrow.	Iron	86-90	chromate resistance; sulfate transport	Homo sapiens	37-40
30561514-13	2019	These results showed a positive translocator protein signal throughout the expansive hyperintense border of rim+ lesions, which co-localized with iron containing CD68+ microglia and macrophages.	Iron	146-150	CD68 molecule	Homo sapiens	162-166
30873821-0	2019	The Deletion of TRPC6 Channels Perturbs Iron and Zinc Homeostasis and Pregnancy Outcome in Mice.	Iron	40-44	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	16-21
30873821-1	2019	BACKGROUND/AIMS: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn).	Iron	159-163	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	17-57
30873821-1	2019	BACKGROUND/AIMS: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn).	Iron	159-163	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	59-64
30873821-1	2019	BACKGROUND/AIMS: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn).	Iron	165-167	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	17-57
30873821-1	2019	BACKGROUND/AIMS: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn).	Iron	165-167	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	59-64
30873821-10	2019	High amounts of Fe were found in the adult brain and liver of TRPC6-/- mice.	Iron	16-18	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	62-67
30873821-12	2019	CONCLUSION: This work indicates that TRPC6 exerts critical pathophysiological functions in placenta, and provides further evidence for a role of this channel in the homeostasis of cations like Zn and Fe.	Iron	200-202	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	37-42
30402883-8	2019	Therefore, it appears that perturbation in iron homoeostasis has essential role in HLA-DR mediated antigen presentation and innate armoury by downregulating iNOS as well as altering IFN-gamma, IL-6 and IL-10 profiles.	Iron	43-47	interleukin 10	Homo sapiens	202-207
30312936-7	2019	In the endometrium, the methylation levels of ACP5 (regulation of endometrial-conceptus iron transport), RGS12 (protein-coupled receptor signalling), and TLR3 (immune response) were increased, while that of EDNRB (corpus luteum maintenance) was decreased.	Iron	88-92	acid phosphatase 5, tartrate resistant	Sus scrofa	46-50
30798817-4	2019	The BMP type I receptors ALK2 and ALK3 are responsible for iron-dependent hepcidin upregulation and basal hepcidin expression, respectively.	Iron	59-63	activin A receptor type 1	Homo sapiens	25-29
30798817-4	2019	The BMP type I receptors ALK2 and ALK3 are responsible for iron-dependent hepcidin upregulation and basal hepcidin expression, respectively.	Iron	59-63	bone morphogenetic protein receptor type 1A	Homo sapiens	34-38
30523271-1	2018	Hepcidin, master regulator of iron homeostasis, causes anemia under infectious and inflammatory conditions by reducing intestinal absorption of iron with decreased release of iron from macrophages and liver despite adequate iron stores leading to Anemia of Inflammation (AI).	Iron	30-34	hepcidin antimicrobial peptide	Mus musculus	0-8
30523271-1	2018	Hepcidin, master regulator of iron homeostasis, causes anemia under infectious and inflammatory conditions by reducing intestinal absorption of iron with decreased release of iron from macrophages and liver despite adequate iron stores leading to Anemia of Inflammation (AI).	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	0-8
30523271-1	2018	Hepcidin, master regulator of iron homeostasis, causes anemia under infectious and inflammatory conditions by reducing intestinal absorption of iron with decreased release of iron from macrophages and liver despite adequate iron stores leading to Anemia of Inflammation (AI).	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	0-8
30523271-1	2018	Hepcidin, master regulator of iron homeostasis, causes anemia under infectious and inflammatory conditions by reducing intestinal absorption of iron with decreased release of iron from macrophages and liver despite adequate iron stores leading to Anemia of Inflammation (AI).	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	0-8
30403845-0	2018	Thermally Persistent High-Spin Ground States in Octahedral Iron Clusters.	Iron	59-63	spindlin 1	Homo sapiens	26-30
30117045-0	2018	Iron chelator deferiprone rescues memory deficits, hippocampal BDNF levels and antioxidant defenses in an experimental model of memory impairment.	Iron	0-4	brain-derived neurotrophic factor	Rattus norvegicus	63-67
30117045-4	2018	In rats, iron overload induces persistent memory deficits, increases oxidative stress and apoptotic markers, and decreases the expression of the synaptic marker, synaptophysin.	Iron	9-13	synaptophysin	Rattus norvegicus	162-175
30353318-3	2018	However, it has recently been demonstrated that other factors, such as iron status, erythropoietin, and inflammation, also affect FGF23 production and metabolism.	Iron	71-75	fibroblast growth factor 23	Homo sapiens	130-135
28884360-9	2018	Zip4 expression was mostly augmented by Ca and Fe; however, ZnT1 showed no change in all conditions studied.	Iron	47-49	solute carrier family 39 member 4	Homo sapiens	0-4
30546390-2	2018	The aim of the present study was to evaluate the effect of a GLP-1 analogue, exenatide, on oxidative stress parameters and apoptotic markers in testicular cells in an iron overload rat model.	Iron	167-171	glucagon	Rattus norvegicus	61-66
30546390-8	2018	A significant reduction was observed in caspase-8 and -3 enzyme staining in testicular stromal and endothelial cells in exenatide injected iron overloaded rats when compared with controls.	Iron	139-143	caspase 8	Rattus norvegicus	40-56
30152072-3	2018	Here, we demonstrate that Mn dose- and time-dependently blocks the protein translation of amyloid precursor protein (APP) and heavy-chain Ferritin (H-Ferritin), both iron homeostatic proteins with neuroprotective features.	Iron	166-170	amyloid beta precursor protein	Rattus norvegicus	90-115
30380148-9	2018	Iron-induced down-regulation on the OPA1 level was also validated by a western blot, which was not reversed by the anti-oxidant but was reversed by the iron chelator.	Iron	0-4	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	36-40
30380148-9	2018	Iron-induced down-regulation on the OPA1 level was also validated by a western blot, which was not reversed by the anti-oxidant but was reversed by the iron chelator.	Iron	152-156	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	36-40
30380148-10	2018	Moreover, an OPA1-associated key downstream effect, mitochondrial fragmentation, was found to be aggravated in neurons exposed to excessive iron, which is consistent with the down-regulation of OPA1.	Iron	140-144	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	13-17
30380148-10	2018	Moreover, an OPA1-associated key downstream effect, mitochondrial fragmentation, was found to be aggravated in neurons exposed to excessive iron, which is consistent with the down-regulation of OPA1.	Iron	140-144	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	194-198
30380148-11	2018	Furthermore, the protein level of PTEN-induced putative kinase 1, an important protein closely related to complex I activity and mitochondrial fragmentation, also significantly declined in neurons by iron overload.	Iron	200-204	PTEN induced kinase 1	Rattus norvegicus	34-64
30485811-5	2018	Depletion of the oxidation-sensitive Fe-S cluster ribosome recycling factor ABCE1 induces the accumulation of 3" UTRs, consistent with a model in which ribosome stalling and mRNA cleavage by No-Go decay yields isolated 3" UTR RNAs protected by ribosomes.	Iron	37-41	ATP binding cassette subfamily E member 1	Homo sapiens	76-81
30381942-5	2018	Consequently, the two adjacent Fe atoms feature unique oscillatory long-range spin coupling.	Iron	31-33	spindlin 1	Homo sapiens	78-82
30427936-7	2018	These findings were supported by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype.	Iron	205-209	ferritin heavy polypeptide 1	Mus musculus	108-136
30427936-7	2018	These findings were supported by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype.	Iron	205-209	ferritin heavy polypeptide 1	Mus musculus	138-142
29909502-0	2018	Increased NGAL level associated with iron store in chronic kidney disease with anemia.	Iron	37-41	lipocalin 2	Homo sapiens	10-14
29909502-2	2018	Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of acute kidney injury, is associated with iron metabolism.	Iron	106-110	lipocalin 2	Homo sapiens	0-42
29909502-2	2018	Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of acute kidney injury, is associated with iron metabolism.	Iron	106-110	lipocalin 2	Homo sapiens	44-48
29909502-3	2018	The present study determined the association between serum NGAL and iron status in chronic kidney disease with anemia.	Iron	68-72	lipocalin 2	Homo sapiens	59-63
29909502-8	2018	NGAL was inversely correlated with hemoglobin, hematocrit, MCV, MCH, serum iron, and TSAT.	Iron	75-79	lipocalin 2	Homo sapiens	0-4
29909502-11	2018	CKD patients with anemia presented altered NGAL values as this protein is involved in the maintenance of iron balance.	Iron	105-109	lipocalin 2	Homo sapiens	43-47
29909502-12	2018	Thus, NGAL might be proposed as a new tool for assessing the iron deficiency and in the management of iron therapy for CKD patients.	Iron	61-65	lipocalin 2	Homo sapiens	6-10
30341696-12	2018	As consequence recent novel therapeutic drugs for neurodegenerative diseases has led to the development of multi target drugs, that possess selective brain MAO A and B inhibitory moiety, iron chelating and antioxidant activities and the ability to increase brain levels of endogenous neurotrophins, such as BDNF, GDNF VEGF and erythropoietin and induce mitochondrial biogenesis.	Iron	187-191	brain derived neurotrophic factor	Homo sapiens	307-311
19454708-8	2009	With iron-restricted bacteria, the Lpp-related growth advantage was evident in infection of MyD88(-/-), but not of C57BL/6, mice.	Iron	5-9	myeloid differentiation primary response gene 88	Mus musculus	92-97
30299927-4	2018	All the five metallic LiMS2 (M = Cr, Mn, Fe, Co, and Ni) materials are superionic conductors with extremely small lithium ion migration barriers in the range from 43 to 99 meV, much lower than most oxide- and even sulfide-type cathodes.	Iron	41-43	LIM zinc finger domain containing 2	Homo sapiens	22-27
19454708-9	2009	On the other hand, iron overload of the host restored the growth deficit of Deltalgt in MyD88(-/-), but not in immunocompetent C57BL/6 mice.	Iron	19-23	myeloid differentiation primary response gene 88	Mus musculus	88-93
19416869-7	2009	Thus, when dystrophin or utrophin binds, actin becomes less like cast iron (strong but brittle) and more like steel (stronger and more resilient).	Iron	70-74	utrophin	Homo sapiens	25-33
30213871-7	2018	Inflammatory induction of hepcidin is suppressed in iron-deficient wild-type mice and recovers after the animals are provided overnight access to an iron-rich diet.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	26-34
30213871-7	2018	Inflammatory induction of hepcidin is suppressed in iron-deficient wild-type mice and recovers after the animals are provided overnight access to an iron-rich diet.	Iron	149-153	hepcidin antimicrobial peptide	Mus musculus	26-34
30479929-4	2018	Distinct iron distribution profiles are also found throughout liver zones in wild-type mice and various mouse models with iron metabolism disorders, including hemochromatosis (Hfe-/- ), iron deficiency, and inflammation.	Iron	9-13	homeostatic iron regulator	Mus musculus	176-179
19298223-0	2009	The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.	Iron	9-13	DNA damage inducible transcript 4	Homo sapiens	125-130
19298223-4	2009	Pathways related to iron metabolism and hypoxia such as growth differentiation factor 15 (GDF-15) and Regulated in development and DNA damage response (REDD1) were also prominent.	Iron	20-24	growth differentiation factor 15	Homo sapiens	56-88
19298223-4	2009	Pathways related to iron metabolism and hypoxia such as growth differentiation factor 15 (GDF-15) and Regulated in development and DNA damage response (REDD1) were also prominent.	Iron	20-24	growth differentiation factor 15	Homo sapiens	90-96
19298223-4	2009	Pathways related to iron metabolism and hypoxia such as growth differentiation factor 15 (GDF-15) and Regulated in development and DNA damage response (REDD1) were also prominent.	Iron	20-24	DNA damage inducible transcript 4	Homo sapiens	152-157
19298223-7	2009	Although iron chelation may affect multiple signaling pathways related to cell survival, our data support the conclusion that REDD1 functions up-stream of tuberin to down-regulate the mTOR pathway in response to deferasirox.	Iron	9-13	DNA damage inducible transcript 4	Homo sapiens	126-131
29927322-0	2018	Liver HFE protein content is posttranscriptionally decreased in iron-deficient mice and rats.	Iron	64-68	homeostatic iron regulator	Mus musculus	6-9
19366358-2	2009	We proposed that intracellular application of the parent, iron-free tetraaza[14]annulene ligand, TAA-1, as precursor would allow antioxidative defense along two lines, i.e. by chelation of potentially toxic cellular iron ions and, subsequently, by catalase-mimic activity.	Iron	216-220	PVR cell adhesion molecule	Rattus norvegicus	97-102
19366358-4	2009	When isolated rat hepatocytes were preloaded with TAA-1, they were protected against iron-induced cell injury and oxidative stress elicited by exposure to the membrane-permeable iron complex Fe(III)/8-hydroxyquinoline.	Iron	85-89	PVR cell adhesion molecule	Rattus norvegicus	50-55
19366358-4	2009	When isolated rat hepatocytes were preloaded with TAA-1, they were protected against iron-induced cell injury and oxidative stress elicited by exposure to the membrane-permeable iron complex Fe(III)/8-hydroxyquinoline.	Iron	178-182	PVR cell adhesion molecule	Rattus norvegicus	50-55
19366358-6	2009	By comparison with authentic TAA-1/Fe, an intracellular formation of 2.0 +/- 0.3 microm of the active catalase mimic in native hepatocytes exposed to TAA-1 and of 6.5 +/- 1.0 microm in hepatocytes exposed to both TAA-1 and iron ions was estimated.	Iron	223-227	PVR cell adhesion molecule	Rattus norvegicus	29-34
19366358-7	2009	The intracellular formation of the active catalase mimic thus renders TAA-1 an attractive compound for protection against iron- and/or hydrogen peroxide-dependent cell injuries.	Iron	122-126	PVR cell adhesion molecule	Rattus norvegicus	70-75
29927322-4	2018	Five-week-old male C57BL/6 mice fed an iron-deficient diet for 4 wk presented with a significant decrease in liver iron content and liver Hamp expression, as well as with a significant decrease in liver HFE protein content.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	138-142
29927322-4	2018	Five-week-old male C57BL/6 mice fed an iron-deficient diet for 4 wk presented with a significant decrease in liver iron content and liver Hamp expression, as well as with a significant decrease in liver HFE protein content.	Iron	39-43	homeostatic iron regulator	Mus musculus	203-206
19207584-0	2009	UGT1A1 gene polymorphism as a potential factor inducing iron overload in the pathogenesis of type 1 hereditary hemochromatosis.	Iron	56-60	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
29927322-11	2018	NEW &amp; NOTEWORTHY Feeding of iron-deficient diet for 4 wk decreased liver HFE protein content in both mice and rats, suggesting that decreased HFE-dependent signaling may contribute to hepcidin downregulation in iron deficiency.	Iron	32-36	homeostatic iron regulator	Mus musculus	77-80
19207584-9	2009	Conclusions UGT1A1 gene polymorphism and as its consequence of high serum bilirubin level may promote iron accumulation in hemochromatosis patients by reducing the activity of inflammation.	Iron	102-106	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	12-18
29990833-8	2018	Finally, the protective effect of EA against iron overload-induced apoptosis was confirmed by western blotting when its treatment upregulated the expressions of caspase-3 and poly(ADP-ribose) polymerase (PARP) proteins.	Iron	45-49	caspase 3	Mus musculus	161-170
19264360-2	2009	In this paper, a BSA (bovine serum albumin)-lecithin liposome system was used to study the nature of different forms of iron, including methemoglobin, hemin and ferric citrate, in catalyzing H(2)O(2)-nitrite system to oxidize protein and lipid as well as nitrate protein.	Iron	120-124	hemoglobin subunit gamma 2	Homo sapiens	136-149
19252923-2	2009	Consequently, plants carefully regulate their iron uptake, dependent on the FRO2 ferric reductase and the IRT1 transporter, to control its homeostasis.	Iron	46-50	iron-regulated transporter 1	Arabidopsis thaliana	106-110
19252923-7	2009	We propose a model where IRT2 likely prevents toxicity from IRT1-dependent iron fluxes in epidermal cells, through compartmentalization.	Iron	75-79	iron-regulated transporter 1	Arabidopsis thaliana	60-64
29990833-8	2018	Finally, the protective effect of EA against iron overload-induced apoptosis was confirmed by western blotting when its treatment upregulated the expressions of caspase-3 and poly(ADP-ribose) polymerase (PARP) proteins.	Iron	45-49	poly (ADP-ribose) polymerase family, member 1	Mus musculus	175-202
29990833-8	2018	Finally, the protective effect of EA against iron overload-induced apoptosis was confirmed by western blotting when its treatment upregulated the expressions of caspase-3 and poly(ADP-ribose) polymerase (PARP) proteins.	Iron	45-49	poly (ADP-ribose) polymerase family, member 1	Mus musculus	204-208
19368350-4	2009	Fe uptake by Caco-2 cells was 14-fold higher from the white bean diet compared to the red bean diet.	Iron	0-2	brain expressed associated with NEDD4 1	Homo sapiens	60-64
30027360-10	2018	Tfr1, Dmt1, ferritin and ferroportin1 exist in bone tissue of rats, and they may be involved in the pathological process of iron overload-induced bone lesion.	Iron	124-128	RoBo-1	Rattus norvegicus	6-10
19368350-4	2009	Fe uptake by Caco-2 cells was 14-fold higher from the white bean diet compared to the red bean diet.	Iron	0-2	brain expressed associated with NEDD4 1	Homo sapiens	90-94
29928961-5	2018	The effects of these drugs and inhibition and overexpression of CISD2 gene were determined by evaluating viability, cell death, lipid ROS production, mitochondrial iron, and mouse tumor xenograft models.	Iron	164-168	CDGSH iron sulfur domain 2	Mus musculus	64-69
19852088-7	2009	AlkB uses a non-heme mononuclear iron(II) and the cofactors 2-ketoglutarate (2KG) and dioxygen to effect oxidative demethylation of the DNA base lesions 1-methyladenine (1-meA), 3-methylcytosine (3-meC), 1-methylguanine (1-meG), and 3-methylthymine (3-meT).	Iron	33-37	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-4
29928961-9	2018	Silencing CISD2 gene rendered resistant HNC cells susceptible to sulfasalazine-induced ferroptosis, with increased levels of lipid ROS and mitochondrial ferrous iron.	Iron	161-165	CDGSH iron sulfur domain 2	Mus musculus	10-15
19339555-6	2009	As impaired Tfn uptake by ClC-4-null fibroblasts could be rescued to wild-type levels by addition of the iron chelator: desoxiferramine, the primary defect in these cells is related to the failure of iron to dissociate from Tfn, a pH-dependent event in endosomes that precedes the dissociation of Tfn from its receptor at the cell surface.	Iron	105-109	transferrin	Mus musculus	12-15
29928961-11	2018	CISD2 inhibition overcomes HNC resistance to ferroptotic cell death induced by sulfasalazine via increased accumulation of mitochondrial ferrous iron and lipid ROS.	Iron	145-149	CDGSH iron sulfur domain 2	Mus musculus	0-5
29573487-7	2018	Reactions of 1 and 6 with Me3 N BH3 were investigated in an attempt to identify Fe-based intermediates in the catalytic reactions.	Iron	80-82	malic enzyme 3	Homo sapiens	26-29
19367733-4	2009	Intact masses of thylakoid membrane proteins were measured, many for the first time, and several proteins were identified with post-translational modifications that were altered by Fe deficiency; for example, the doubly phosphorylated form of the photosystem II oxygen evolving complex, PSBH, increased under Fe-deficiency.	Iron	181-183	photosystem II protein H	Arabidopsis thaliana	287-291
19233206-4	2009	We have developed a Caenorhabditis elegans model to investigate the molecular and catalytic effects of mutations in the sdhb-1 gene, which encodes the SDH iron-sulfur subunit.	Iron	155-159	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Caenorhabditis elegans	120-126
30294279-5	2018	Proinflammatory cytokine, mainly IL-6, which are released by both tumor and immune cells, play a pivotal action in CRA etiopathogenesis: they promote alterations in erythroid progenitor proliferation, erythropoietin (EPO) production, survival of circulating erythrocytes, iron balance, redox status, and energy metabolism, all of which can lead to anemia.	Iron	272-276	myotubularin related protein 11	Homo sapiens	115-118
19245872-0	2009	Regulation of Iron Homeostasis: Is It All in the HBD?	Iron	14-18	HBD	Homo sapiens	49-52
19252488-1	2009	Expression of hepcidin, a key regulator of intestinal iron absorption, can be induced in vitro by several bone morphogenetic proteins (BMPs), including BMP2, BMP4 and BMP9 (refs.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	14-22
19252488-1	2009	Expression of hepcidin, a key regulator of intestinal iron absorption, can be induced in vitro by several bone morphogenetic proteins (BMPs), including BMP2, BMP4 and BMP9 (refs.	Iron	54-58	growth differentiation factor 2	Mus musculus	167-171
19292462-1	2009	Ferritin-iron has been shown to be as bioavailable as ferrous sulfate in humans.	Iron	9-13	Fer2	Triticum aestivum	0-8
29917289-4	2018	Here, we show that FH inactivation (FH-/- ) proves synthetic lethal with inducers of ferroptosis, an iron-dependent and nonapoptotic form of cell death.	Iron	101-105	fumarate hydratase	Homo sapiens	19-21
19235734-4	2009	Flow cytometric analysis of developing Nme1(-/-)/Nme2(-/-) erythroid cells indicated that the major iron transport receptor molecule TfR1 is attenuated concomitant with a reduction of intracellular iron, suggesting that TfR1 is a downstream target of NDPKs and that reduced iron in Nme1(-/-)/Nme2(-/-) erythroblasts is inhibiting their development.	Iron	100-104	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	39-53
19168643-5	2009	This production, which is sensitive to NO synthase inhibitors, does not involve nitrate reductase and AtNOA1 but requires IRT1, encoding a major plasma membrane transporter for iron but also Cd(2+).	Iron	177-181	iron-regulated transporter 1	Arabidopsis thaliana	122-126
29778810-3	2018	Here we reported the debromination pathways of three BDE congeners (BDE-21, 25 and 29) by nano-zerovalent iron (n-ZVI).	Iron	106-110	homeobox D13	Homo sapiens	53-56
19283067-4	2009	In this report, we demonstrate that prion disease-affected human, hamster, and mouse brains show increased total and redox-active Fe (II) iron, and a paradoxical increase in major iron uptake proteins transferrin (Tf) and transferrin receptor (TfR) at the end stage of disease.	Iron	180-184	transferrin	Mus musculus	201-212
19283067-4	2009	In this report, we demonstrate that prion disease-affected human, hamster, and mouse brains show increased total and redox-active Fe (II) iron, and a paradoxical increase in major iron uptake proteins transferrin (Tf) and transferrin receptor (TfR) at the end stage of disease.	Iron	180-184	transferrin	Mus musculus	214-216
29778810-3	2018	Here we reported the debromination pathways of three BDE congeners (BDE-21, 25 and 29) by nano-zerovalent iron (n-ZVI).	Iron	106-110	homeobox D13	Homo sapiens	68-71
29778810-6	2018	Singly occupied molecular orbitals of BDE anions are well correlated with their actual debromination pathways, which successfully explain why these BDE congeners exhibit certain debromination pathways in n-ZVI system.	Iron	206-209	homeobox D13	Homo sapiens	38-41
19047680-6	2009	We also report significant induction of serum GDF15 in iron-deficient subjects and after administration of an iron chelator to normal subjects.	Iron	55-59	growth differentiation factor 15	Homo sapiens	46-51
19047680-6	2009	We also report significant induction of serum GDF15 in iron-deficient subjects and after administration of an iron chelator to normal subjects.	Iron	110-114	growth differentiation factor 15	Homo sapiens	46-51
29778810-6	2018	Singly occupied molecular orbitals of BDE anions are well correlated with their actual debromination pathways, which successfully explain why these BDE congeners exhibit certain debromination pathways in n-ZVI system.	Iron	206-209	homeobox D13	Homo sapiens	148-151
19047680-7	2009	These findings indicate that GDF15 can be induced by pathophysiologic changes in iron availability, raising important questions about the mechanism of regulation and its role in iron homeostasis.	Iron	81-85	growth differentiation factor 15	Homo sapiens	29-34
19047680-7	2009	These findings indicate that GDF15 can be induced by pathophysiologic changes in iron availability, raising important questions about the mechanism of regulation and its role in iron homeostasis.	Iron	178-182	growth differentiation factor 15	Homo sapiens	29-34
29778810-7	2018	In addition, microscale zerovalent zinc (m-ZVZ), iron-based bimetals (Fe/Ag and Fe/Pd) were also used to debrominate PBDEs, with BDE-21 as target pollutant.	Iron	49-53	homeobox D13	Homo sapiens	118-121
29426274-1	2018	We describe a new Italian family with 7 members affected by hereditary hyperferritinemia cataract syndrome (HHCS), an uncommon autosomal dominant disease caused by mutations of the iron-responsive element (IRE) of the ferritin light chain (FTL) gene determining its overexpression.	Iron	181-185	ferritin light chain	Homo sapiens	218-238
19109972-6	2009	In the CAT-1 structure, we found three interesting features related to its unusual kinetics: (a) a constriction in the channel that conveys H(2)O(2) to the active site; (b) a covalent bond between the tyrosine, which forms the fifth coordination bound to the iron of the heme, and a vicinal cysteine; (c) oxidation of the pyrrole ring III to form a cis-hydroxyl group in C5 and a cis-gamma-spirolactone in C6.	Iron	259-263	transient receptor potential cation channel subfamily V member 6	Homo sapiens	7-12
29426274-1	2018	We describe a new Italian family with 7 members affected by hereditary hyperferritinemia cataract syndrome (HHCS), an uncommon autosomal dominant disease caused by mutations of the iron-responsive element (IRE) of the ferritin light chain (FTL) gene determining its overexpression.	Iron	181-185	ferritin light chain	Homo sapiens	240-243
30018160-8	2018	Importantly, iron overload exacerbated the risk of HT after early tPA administration, accelerated ischemia-induced serum matrix metalloproteinase-9 increase, and enhanced basal serum lipid peroxidation.	Iron	13-17	matrix metallopeptidase 9	Homo sapiens	121-147
19096759-5	2009	In support of this hypothesis, our data show that three different classes of enzymes in this iron- and 2-oxoglutarate-dependent dioxygenase family, including HIF-prolyl hydroxylase PHD2, histone demethylase JHDM2A/JMJD1A, and DNA repair enzyme ABH3, are all highly sensitive to nickel inhibition.	Iron	93-97	lysine demethylase 3A	Homo sapiens	207-213
19096759-5	2009	In support of this hypothesis, our data show that three different classes of enzymes in this iron- and 2-oxoglutarate-dependent dioxygenase family, including HIF-prolyl hydroxylase PHD2, histone demethylase JHDM2A/JMJD1A, and DNA repair enzyme ABH3, are all highly sensitive to nickel inhibition.	Iron	93-97	lysine demethylase 3A	Homo sapiens	214-220
30425415-6	2018	Notable examples are Ftr1 iron permease and Fet3 ferro-O2-oxidoreductase, elements of the reductive iron assimilation pathway, in the S. cerevisiae-based model, as well as MpkC, a HogA-like mitogen activated protein kinase in the A. nidulans-based model.	Iron	26-30	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	21-25
19589017-4	2009	Most important, the peculiar distribution of various polymorphisms, such as blood group O, factor V Leiden, DF508, C282Y, and CCR5 D32 mutations, which are implicated in resistance to infection, hemostasis, or iron conservation, could be interpreted as an adaptive profile.	Iron	210-214	C-C motif chemokine receptor 5	Homo sapiens	126-130
30425415-6	2018	Notable examples are Ftr1 iron permease and Fet3 ferro-O2-oxidoreductase, elements of the reductive iron assimilation pathway, in the S. cerevisiae-based model, as well as MpkC, a HogA-like mitogen activated protein kinase in the A. nidulans-based model.	Iron	100-104	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	21-25
30154413-9	2018	Haemoglobin also caused proliferation of hPASMCs; in other novel findings, CD163, the haemoglobin/haptoglobin receptor, was found on these cells and offers a means for cellular uptake of iron via haemoglobin.	Iron	187-191	CD163 molecule	Homo sapiens	75-80
18922858-6	2009	This work defines the respective roles of IRP2 in the determination of critical body iron parameters such as organ iron loading and erythropoiesis.	Iron	85-89	iron responsive element binding protein 2	Mus musculus	42-46
18922858-6	2009	This work defines the respective roles of IRP2 in the determination of critical body iron parameters such as organ iron loading and erythropoiesis.	Iron	115-119	iron responsive element binding protein 2	Mus musculus	42-46
19907155-3	2009	Improved understanding of how iron metabolism is controlled by proteins such as hepcidin, ferroportin, hypoxia-inducible factor 1, and growth differentiation factor 15 have revealed how they are involved in the organ toxicity of SCD.	Iron	30-34	growth differentiation factor 15	Homo sapiens	135-167
18992754-11	2009	These findings indicate that excessive free iron and the resultant enhanced oxidative stress caused by downregulation of FHC lead to cardiomyocyte death.	Iron	44-48	ferritin heavy polypeptide 1	Mus musculus	121-124
29546482-0	2018	Genome-wide and comparative analysis of bHLH38, bHLH39, bHLH100 and bHLH101 genes in Arabidopsis, tomato, rice, soybean and maize: insights into iron (Fe) homeostasis.	Iron	145-149	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	40-46
18817857-8	2008	Genomic analysis of the promoter regions of these two frog hepcidin genes indicates that transcription regulation factors NF-kappaB and C/EBPbeta may be involved in hepcidin regulation by iron.	Iron	188-192	CCAAT enhancer binding protein beta	Xenopus tropicalis	136-145
29546482-5	2018	In this study, we aimed to understand the roles of bHLH38, bHLH39, bHLH100 and bHLH101 genes for Fe homeostasis in Arabidopsis, tomato, rice, soybean and maize species by using bioinformatics approaches.	Iron	97-99	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	51-57
29546482-5	2018	In this study, we aimed to understand the roles of bHLH38, bHLH39, bHLH100 and bHLH101 genes for Fe homeostasis in Arabidopsis, tomato, rice, soybean and maize species by using bioinformatics approaches.	Iron	97-99	basic helix-loop-helix protein 100	Arabidopsis thaliana	67-74
29938779-3	2018	Our perception of iron metabolism has been completely changed by an improved definition of cellular and systemic iron homeostasis, of the molecular pathogenesis of iron disorders, the fine tuning of the iron hormone hepcidin by activators and inhibitors and the dissection of the components of the hepcidin regulatory pathway.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	216-224
19077278-1	2008	BACKGROUND: Lipocalin 2, an iron binding protein, is abnormally expressed in some malignant human cancers and may play an important role in tumor metastasis.	Iron	28-32	lipocalin 2	Homo sapiens	12-23
26620478-0	2008	Accurate Spin-State Energies for Iron Complexes.	Iron	33-37	spindlin 1	Homo sapiens	9-13
29938779-3	2018	Our perception of iron metabolism has been completely changed by an improved definition of cellular and systemic iron homeostasis, of the molecular pathogenesis of iron disorders, the fine tuning of the iron hormone hepcidin by activators and inhibitors and the dissection of the components of the hepcidin regulatory pathway.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	298-306
26620478-1	2008	A critical assessment of the OPBE functional is made for its performance for the geometries and spin-states of iron complexes.	Iron	111-115	spindlin 1	Homo sapiens	96-100
29989329-11	2018	These results showed that high ROS levels induced by iron overload polarized macrophages to the M1 subtype by enhancing p300/CBP acetyltransferase activity and promoting p53 acetylation.	Iron	53-57	E1A binding protein p300	Mus musculus	120-124
29989329-11	2018	These results showed that high ROS levels induced by iron overload polarized macrophages to the M1 subtype by enhancing p300/CBP acetyltransferase activity and promoting p53 acetylation.	Iron	53-57	CREB binding protein	Mus musculus	125-128
29655636-8	2018	CHr levels were lower in subjects with low values of Hb, ferritin, serum iron and MCV compared to subjects with normal values for these parameters.	Iron	73-77	chromate resistance; sulfate transport	Homo sapiens	0-3
18759068-11	2008	Supplemental Fe linearly (p &lt; 0.05) improved the total red blood cells, hemoglobin, plasma, and liver (p = 0.109) Fe status of pigs and also increased (linear and quadratic, p &lt; 0.001) the fecal excretion of Fe on days 14 and 28.	Iron	13-15	HGB	Sus scrofa	75-85
18562192-3	2008	Results showed that the optimized conditions of the GOx/CHIT film induced NdHCF NPs for the biosensing of glucose were 1.0mM Nd(3+) and 20.0mM Fe(CN)(6)(3-).	Iron	143-145	hydroxyacid oxidase 1	Homo sapiens	52-55
29655636-11	2018	CHr measurement might have additional value in iron status assessment.	Iron	47-51	chromate resistance; sulfate transport	Homo sapiens	0-3
29181658-3	2018	Iron deficiency promotes transcription of FGF23 and iron-supplementation for iron deficiency decreases serum FGF23 levels.	Iron	52-56	fibroblast growth factor 23	Homo sapiens	109-114
19068821-4	2008	Excellent agreement between observed biphasic NAC reduction kinetics and model fits points toward existence of two types of Fe(II) sites exhibiting reactivities that differ by 3 orders of magnitude in iron-rich ferruginous smectite (SWa-1) and Olberg montmorillonite.	Iron	201-205	X-linked Kx blood group	Homo sapiens	46-49
19068821-5	2008	Low structural Fe content, as found in Wyoming montmorillonite (SWy-2), impedes the formation of highly reactive Fe sites and results in pseudo-first order kinetics of NAC reduction that originate from the presence of a single type of Fe(II) species of even lower reactivity.	Iron	15-17	X-linked Kx blood group	Homo sapiens	168-171
18579343-7	2008	Pre-treatment of rats with Fe(TPPS) significantly attenuated or prevented all these markers at both post-lesion times tested, except for GFAP immunoreactivity at 7 days post-lesion and iNOS immunoreactivity at 1 day post-lesion.	Iron	27-29	glial fibrillary acidic protein	Rattus norvegicus	137-141
18715869-0	2008	The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.	Iron	129-133	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	104-108
18715869-6	2008	We demonstrate that the degradation of succinate dehydrogenase SDH4 mRNA, a known target of Cth2 on iron-deficient conditions, depends on Dhh1.	Iron	100-104	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	63-67
29721575-0	2018	Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells.	Iron	0-4	sphingolipid transporter 2	Homo sapiens	24-29
18775698-2	2008	The AlkB family proteins utilize iron(II), alpha-ketoglutarate (alpha-KG) and dioxygen to perform oxidative repair of alkylated nucleobases in DNA and RNA.	Iron	33-37	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	4-8
29721575-6	2018	METHODS: We studied, by using the MG-63 cell lines, the effect of iron excess on SPNS2 gene expression which was previously identified by us as potentially iron-regulated.	Iron	66-70	sphingolipid transporter 2	Homo sapiens	81-86
18665838-1	2008	Haem-regulated eIF2alpha kinase (HRI) is essential for the regulation of globin gene translation and the survival of erythroid precursors in iron/haem deficiency.	Iron	141-145	eukaryotic translation initiation factor 2A	Homo sapiens	15-24
29721575-6	2018	METHODS: We studied, by using the MG-63 cell lines, the effect of iron excess on SPNS2 gene expression which was previously identified by us as potentially iron-regulated.	Iron	156-160	sphingolipid transporter 2	Homo sapiens	81-86
29721575-8	2018	The SPNS2-associated function was also investigated in MG-63 cells by fluxomic strategy which led us to determinate the S1P efflux in iron excess condition.	Iron	134-138	sphingolipid transporter 2	Homo sapiens	4-9
18554871-3	2008	The haptoglobin HP2-2 genotype has been associated with idiopathic generalized epilepsies and altered iron metabolism in children with alpha-thalassaemia can potentially interfere with neurotransmission and increase the risk of seizures.	Iron	102-106	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	16-21
29721575-9	2018	RESULTS: We showed in MG-63 cells that iron exposure strongly increased the mRNA level of the SPNS2 gene.	Iron	39-43	sphingolipid transporter 2	Homo sapiens	94-99
29721575-12	2018	Iron excess did not modulate SPHK1, SPHK2, SGPL1, or SGPP1 gene expression, but decreased COL1A1 and S1PR1 mRNA levels, suggesting a functional implication of low extracellular S1P concentration on the S1P/S1PR signalizing axis.	Iron	0-4	collagen type I alpha 1 chain	Homo sapiens	90-96
18694968-6	2008	This pathology is characterized by increased serum transferrin saturation with iron deposition in parenchymal cells, mainly in the liver, and is most often associated with mutations in the gene encoding the molecule HFE.	Iron	79-83	homeostatic iron regulator	Mus musculus	216-219
29721575-12	2018	Iron excess did not modulate SPHK1, SPHK2, SGPL1, or SGPP1 gene expression, but decreased COL1A1 and S1PR1 mRNA levels, suggesting a functional implication of low extracellular S1P concentration on the S1P/S1PR signalizing axis.	Iron	0-4	sphingosine-1-phosphate receptor 1	Homo sapiens	101-106
18694968-7	2008	In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe(-/-) and beta2m(-/-), show an increased susceptibility to experimental infection with M. avium and that during infection these animals accumulate iron inside granuloma macrophages.	Iron	78-82	homeostatic iron regulator	Mus musculus	104-107
18694968-7	2008	In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe(-/-) and beta2m(-/-), show an increased susceptibility to experimental infection with M. avium and that during infection these animals accumulate iron inside granuloma macrophages.	Iron	254-258	homeostatic iron regulator	Mus musculus	104-107
30028260-4	2018	Iron, the degradation product of hemoglobin, correlates with Abeta.	Iron	0-4	amyloid beta precursor protein	Rattus norvegicus	61-66
19017209-5	2008	Iron-titanium-sulphides form in close proximity to MnS precipitates that contain iron.	Iron	81-85	glycophorin E (MNS blood group)	Homo sapiens	51-54
29980749-3	2018	Here using a Fe/Al2O3/BN tunnel barrier, we demonstrate both effects in a single device in Bi2Te3: the electrical detection of the spin accumulation generated by an unpolarized current flowing through the surface states, and that of the charge accumulation generated by spins injected into the surface state system.	Iron	13-15	spindlin 1	Homo sapiens	131-135
18767815-4	2008	In this work, a valine residue was introduced at position 64 (H64V variant) to clarify the possible role(s) of the distal residue in protecting the heme iron of Ngb from attack by strong oxidants.	Iron	153-157	neuroglobin	Homo sapiens	161-164
18712936-9	2008	Induction of specific iron binding implies that (1) the structure of mICA resembles those of other TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron binds.	Iron	22-26	transferrin	Mus musculus	99-101
30002810-7	2018	Analysis of iron homeostatic proteins revealed increased expression of IRP1, Tf, ferritin and TfR in N171-82Q mice striatum and cortex.	Iron	12-16	aconitase 1	Mus musculus	71-75
18712936-9	2008	Induction of specific iron binding implies that (1) the structure of mICA resembles those of other TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron binds.	Iron	192-196	transferrin	Mus musculus	99-101
18768801-7	2008	In addition, we show that the prosurvival activity of NGAL is mediated by its ability to bind and transport iron inside the cells.	Iron	108-112	lipocalin 2	Homo sapiens	54-58
18768801-8	2008	Our data suggest that NF-kappaB contributes to thyroid tumor cell survival by controlling iron uptake via NGAL.	Iron	90-94	lipocalin 2	Homo sapiens	106-110
30002810-7	2018	Analysis of iron homeostatic proteins revealed increased expression of IRP1, Tf, ferritin and TfR in N171-82Q mice striatum and cortex.	Iron	12-16	transferrin	Mus musculus	77-79
30002810-9	2018	Conclusion: We conclude that mutant huntingtin may cause abnormal iron homeostatic pathways by increasing IRP1 expression in Huntington"s disease, suggesting potential therapeutic target.	Iron	66-70	aconitase 1	Mus musculus	106-110
29409695-8	2018	Since low red cell indices were a feature of all forms of alpha thalassaemia and also of iron deficiency, in areas where both conditions are common, such as Sri Lanka, it is imperative to differentiate between the two, to allow targeted administration of iron supplements and avoid the possible deleterious effects of increased iron availability in iron replete individuals with low red cell indices due to other causes such as alpha thalassaemia.	Iron	255-259	sorcin	Homo sapiens	157-160
17916327-2	2008	The iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane receptor, a periplasmic binding protein (PBP), and an inner membrane ATP-binding cassette (ABC) transporter.	Iron	4-8	phosphatidylethanolamine binding protein 1	Homo sapiens	144-171
17916327-2	2008	The iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane receptor, a periplasmic binding protein (PBP), and an inner membrane ATP-binding cassette (ABC) transporter.	Iron	4-8	phosphatidylethanolamine binding protein 1	Homo sapiens	173-176
18519167-1	2008	Lipocalin 2 (Lcn2), a mammalian protein that is expressed and secreted in various pathologic states, binds siderophores, which are high-affinity iron chelators.	Iron	145-149	lipocalin 2	Homo sapiens	0-11
29409695-8	2018	Since low red cell indices were a feature of all forms of alpha thalassaemia and also of iron deficiency, in areas where both conditions are common, such as Sri Lanka, it is imperative to differentiate between the two, to allow targeted administration of iron supplements and avoid the possible deleterious effects of increased iron availability in iron replete individuals with low red cell indices due to other causes such as alpha thalassaemia.	Iron	255-259	sorcin	Homo sapiens	157-160
18519167-1	2008	Lipocalin 2 (Lcn2), a mammalian protein that is expressed and secreted in various pathologic states, binds siderophores, which are high-affinity iron chelators.	Iron	145-149	lipocalin 2	Homo sapiens	13-17
29377263-10	2018	Meanwhile, the expected downstream effects of elevated hepcidin, namely decreased FPN1 expression and increased Ft-L protein and non-heme iron concentrations in the spleen, were observed after the continuous AD or NE treatments.	Iron	138-142	hepcidin antimicrobial peptide	Mus musculus	55-63
18519167-2	2008	Besides its role in limiting iron availability to pathogens in the setting of bacterial infection, Lcn2:siderophore complexes can also deliver iron to cells.	Iron	29-33	lipocalin 2	Homo sapiens	99-103
18519167-2	2008	Besides its role in limiting iron availability to pathogens in the setting of bacterial infection, Lcn2:siderophore complexes can also deliver iron to cells.	Iron	143-147	lipocalin 2	Homo sapiens	99-103
18519167-4	2008	Anemia induced by phlebotomy, iron deprivation, or phenylhydrazine treatment was associated with upregulation of Lcn2 gene expression in the liver and elevation of serum Lcn2 protein levels.	Iron	30-34	lipocalin 2	Homo sapiens	113-117
18519167-4	2008	Anemia induced by phlebotomy, iron deprivation, or phenylhydrazine treatment was associated with upregulation of Lcn2 gene expression in the liver and elevation of serum Lcn2 protein levels.	Iron	30-34	lipocalin 2	Homo sapiens	170-174
18519167-7	2008	The upregulation of Lcn2 levels by anemia and hypoxia, which is not directly mediated by iron or erythropoietin, suggests a possible physiological role for Lcn2 during increased iron utilization and mobilization from stores.	Iron	178-182	lipocalin 2	Homo sapiens	20-24
18519167-7	2008	The upregulation of Lcn2 levels by anemia and hypoxia, which is not directly mediated by iron or erythropoietin, suggests a possible physiological role for Lcn2 during increased iron utilization and mobilization from stores.	Iron	178-182	lipocalin 2	Homo sapiens	156-160
29377263-12	2018	The elevated hepatic hepcidin decreased FPN1 levels in the spleen, likely causing the increased iron accumulation in the spleen.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	21-29
18552213-2	2008	Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1).	Iron	6-10	transferrin	Mus musculus	23-34
29688414-8	2018	Results indicated that addition of the E. coli phytase to the negative control diet tended to quadratically improve the apparent ileal digestibility of Phe (P = 0.086) and Asp (P = 0.054), and linearly increased (P &lt; 0.05) the apparent total tract digestibility (ATTD) of ADF, K, and Fe.	Iron	287-289	phytase	Zea mays	47-54
18549825-7	2008	This activates HIF-1alpha that induces the expression of TfR, which in turn increases Tf uptake and iron accumulation and exacerbates oxidative damage that increases the lipid peroxidation.	Iron	100-104	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	15-25
29688414-10	2018	In conclusion, the increased absorption of several minerals including Ca, P, K, Mg, and Fe that was observed as increasing concentrations of an E. coli phytase was added to a corn-SBM meal diet indicates that the dietary provision of these minerals may be reduced if phytase is fed.	Iron	88-90	phytase	Zea mays	152-159
18593702-1	2008	Ferrochelatase catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme.	Iron	42-54	ferrochelatase	Mus musculus	0-14
30004765-0	2018	Odd and Even Modes of Neutron Spin Resonance in the Bilayer Iron-Based Superconductor CaKFe_{4}As_{4}.	Iron	60-64	spindlin 1	Homo sapiens	30-34
18593702-4	2008	These analyses reveal that purified recombinant ferrochelatase from both murine and yeast sources inserts not only ferrous iron but also divalent cobalt, zinc, nickel, and copper into protoporphyrin IX to form the corresponding metalloporphyrins but with considerable mechanistic variability.	Iron	123-127	ferrochelatase	Mus musculus	48-62
18685102-7	2008	We suggest that Tempol protected IRP2(-/-) mice by disassembling the cytosolic iron-sulfur cluster of IRP1 and activating IRE binding activity, which stabilized the TfR1 transcript, repressed ferritin synthesis, and partially restored normal cellular iron homeostasis in the brain.	Iron	79-83	aconitase 1	Mus musculus	102-106
29749962-1	2018	With classic molecular dynamics simulations, we investigate the effects of temperature and void on the bcc to hcp/fcc structural transition in single crystal iron driven by 1D ([0 0 1]) and 3D (uniform) compressions.	Iron	158-162	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	110-113
18664788-2	2008	These two mechanisms have opposite effects on iron homeostasis, especially on the expression of the iron regulatory hormone hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	124-132
18664788-2	2008	These two mechanisms have opposite effects on iron homeostasis, especially on the expression of the iron regulatory hormone hepcidin.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	124-132
18756096-1	2008	In our previous study, the expression of active H-ferritins in Saccharomyces cerevisiae was found to reduce cell growth and reactive oxygen species (ROS) generation upon exposure to oxidative stress; such expression enhanced that of high-affinity iron transport genes (FET3 and FTR1).	Iron	247-251	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	278-282
29872820-0	2018	The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells.	Iron	19-23	retinoic acid receptor responder 2	Homo sapiens	27-35
18505821-2	2008	We identify heme, an iron-containing prosthetic group, as a regulatory ligand controlling human Period-2 (hPer2) stability.	Iron	21-25	period circadian regulator 2	Homo sapiens	96-104
18505821-2	2008	We identify heme, an iron-containing prosthetic group, as a regulatory ligand controlling human Period-2 (hPer2) stability.	Iron	21-25	period circadian regulator 2	Homo sapiens	106-111
29872820-4	2018	The data showed that chemerin only decreases the content of intracellular iron in SMMC7721 cells.	Iron	74-78	retinoic acid receptor responder 2	Homo sapiens	21-29
29872820-6	2018	Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin.	Iron	43-47	retinoic acid receptor responder 2	Homo sapiens	166-174
18519569-2	2008	Increased iron accumulation is caused by hepcidin-mediated down-regulation of the iron export protein ferroportin and higher iron uptake.	Iron	10-14	hepcidin antimicrobial peptide	Mus musculus	41-49
18519569-2	2008	Increased iron accumulation is caused by hepcidin-mediated down-regulation of the iron export protein ferroportin and higher iron uptake.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	41-49
18519569-2	2008	Increased iron accumulation is caused by hepcidin-mediated down-regulation of the iron export protein ferroportin and higher iron uptake.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	41-49
29872820-7	2018	Conversely, iron addition led to recovery from the inhibitory effect of chemerin on SMMC7721 cells.	Iron	12-16	retinoic acid receptor responder 2	Homo sapiens	72-80
29872820-8	2018	The results suggest that chemerin plays an important role in inhibiting the cell proliferation of hepatocellular carcinomas by interfering with cellular iron homeostasis in this type of tumors.	Iron	153-157	retinoic acid receptor responder 2	Homo sapiens	25-33
18627600-11	2008	It revealed the transcriptional regulation of PDR1 by Rpn4p, proposed a new role for the pleiotropic drug resistance network in stress response and demonstrated a direct regulatory connection between oxidative stress response and iron homeostasis.	Iron	230-234	stress-regulated transcription factor RPN4	Saccharomyces cerevisiae S288C	54-59
29906288-7	2018	After heterologous expression in Arabidopsis thaliana, LIR1 decreases the iron content of leaves and worsens the chlorotic phenotype of plants lacking the iron importer IRT1.	Iron	155-159	iron-regulated transporter 1	Arabidopsis thaliana	169-173
18621680-6	2008	Our investigation showed that increased MIT Fe in the myocardium of mutants was due to marked transferrin Fe uptake, which was the result of enhanced transferrin receptor 1 expression.	Iron	44-46	transferrin	Mus musculus	94-105
18621680-6	2008	Our investigation showed that increased MIT Fe in the myocardium of mutants was due to marked transferrin Fe uptake, which was the result of enhanced transferrin receptor 1 expression.	Iron	106-108	transferrin	Mus musculus	94-105
18621680-8	2008	These studies demonstrated that loss of Fxn alters cardiac Fe metabolism due to pronounced changes in Fe trafficking away from the cytosol to the mitochondrion.	Iron	59-61	frataxin	Mus musculus	40-43
18621680-8	2008	These studies demonstrated that loss of Fxn alters cardiac Fe metabolism due to pronounced changes in Fe trafficking away from the cytosol to the mitochondrion.	Iron	102-104	frataxin	Mus musculus	40-43
18621680-11	2008	In summary, we show that loss of Fxn markedly alters cellular Fe trafficking and that Fe chelation limits myocardial hypertrophy in the mutant.	Iron	62-64	frataxin	Mus musculus	33-36
18450746-1	2008	Heme-regulated eukaryotic initiation factor 2alpha (eIF2alpha) kinase (HRI) functions in response to the heme iron concentration.	Iron	110-114	eukaryotic translation initiation factor 2A	Homo sapiens	52-61
18450746-3	2008	Conversely, upon heme iron shortage, HRI autophosphorylates and subsequently phosphorylates the substrate, eIF2alpha, leading to the termination of protein synthesis.	Iron	22-26	eukaryotic translation initiation factor 2A	Homo sapiens	107-116
29667051-8	2018	If a PBR is to be used, the Fe load should be &lt; 26 g/m3 substrate/day (Fe &lt; 200 mg/L) and SO42- &lt; 110 g/m3 substrate/day; (2) PBR/DAS filled with a mixture with at least 20% of neutralizing agent; (3) include Q and ksat (&gt; 10-3 cm/s) in the long-term prediction.	Iron	28-30	translocator protein	Homo sapiens	5-8
17522609-0	2008	The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka.	Iron	113-117	sorcin	Homo sapiens	139-142
29543343-1	2018	OBJECTIVE: During hypoxia, hepcidin expression is inhibited to allow iron mobilization to sustain erythropoietic expansion.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	27-35
18363860-2	2008	In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis.	Iron	98-102	BTB (POZ) domain containing 9	Mus musculus	52-57
29280002-2	2018	Multiprotein machineries (NIF, ISC, SUF) exist for Fe-S cluster biogenesis which are mainly conserved from bacteria to human.	Iron	51-55	S100 calcium binding protein A9	Homo sapiens	26-29
18544868-4	2008	The method was applied to the simultaneous determination of trace Fe and Al in tap water, lake water, river water and tea leaves without separation and preconcentration.	Iron	66-68	nuclear RNA export factor 1	Homo sapiens	79-82
29575577-1	2018	To maintain iron homoeostasis, the iron regulatory hormone hepcidin is tightly controlled by BMP-Smad signalling pathway, but the physiological role of Smad7 in hepcidin regulation remains elusive.	Iron	12-16	hepcidin antimicrobial peptide	Mus musculus	59-67
18589954-8	2008	Our results suggest that green rusts may contribute to abiotic natural attenuation of RDX in Fe-rich subsurface environments, but that it will be important to consider groundwater composition when assessing rates of attenuation.	Iron	93-95	radixin	Homo sapiens	86-89
29378199-10	2018	Further, we found that iron activated the JNK, ERK and NF-kappaB signaling pathways in vivo.	Iron	23-27	mitogen-activated protein kinase 8	Mus musculus	42-45
29602224-8	2018	Several TOR- and ABA-responsive genes are differentially expressed in tip41, including iron homeostasis, senescence and ethylene-associated genes.	Iron	87-91	tonoplast intrinsic protein 4;1	Arabidopsis thaliana	70-75
17936676-6	2008	Ferric ammonium citrate (FAC), a source of iron, at 15 microg/ml increased MMP-9 in both cell lines in a dose-dependent manner as shown by reverse transcription polymerase chain reaction and gelatin zymography analyses.	Iron	43-47	matrix metallopeptidase 9	Homo sapiens	75-80
17936676-7	2008	Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt.	Iron	120-124	matrix metallopeptidase 9	Homo sapiens	135-140
17936676-8	2008	Analysis of electrophoretic mobility shift assay revealed that iron induces MMP-9 expression by activation of activated protein-1 (AP-1).	Iron	63-67	matrix metallopeptidase 9	Homo sapiens	76-81
17936676-10	2008	In conclusion, this study is the first to demonstrate that MMP-9 was up-regulated by iron in HNSCC cell lines.	Iron	85-89	matrix metallopeptidase 9	Homo sapiens	59-64
29799786-1	2018	Iron-loading disorders, such as hereditary hemochromatosis, are associated with inappropriately low expression of the iron regulatory hormone, hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	143-151
17936676-11	2008	We suggest that iron may be one of several factors that cause an increase of MMP-9, which is necessary for the development and progression of HNSCC.	Iron	16-20	matrix metallopeptidase 9	Homo sapiens	77-82
29799786-1	2018	Iron-loading disorders, such as hereditary hemochromatosis, are associated with inappropriately low expression of the iron regulatory hormone, hepcidin.	Iron	118-122	hepcidin antimicrobial peptide	Mus musculus	143-151
18375546-7	2008	Concerning messenger RNA (mRNA) and protein levels of spleen iron recycling markers from RBC degradation (DMT1 [divalent metal transporter 1], iron regulated protein 1, HO1, HO2 [heme oxygenase 1 and 2], cluster of differentiation 36), increase in HO2 and DMT1 mRNA level was induced after chronic exposure to DU.	Iron	61-65	RoBo-1	Rattus norvegicus	106-110
29799786-8	2018	These results indicate that Hamp1 induction by food deprivation is independent of HFE and suggest that targeting the pathway regulated by food deprivation could have clinical benefit in iron-loading conditions.-Mirciov, C. S. G., Wilkins, S. J., Anderson, G. J., Frazer, D. M. Food deprivation increases hepatic hepcidin expression and can overcome the effect of Hfe deletion in male mice.	Iron	186-190	hepcidin antimicrobial peptide	Mus musculus	28-33
18393371-0	2008	The role of Hfe in transferrin-bound iron uptake by hepatocytes.	Iron	37-41	homeostatic iron regulator	Mus musculus	12-15
18393371-0	2008	The role of Hfe in transferrin-bound iron uptake by hepatocytes.	Iron	37-41	transferrin	Mus musculus	19-30
29610275-3	2018	Here, we characterized uptake of transferrin (Tf)-bound iron (TBI) and non-Tf-bound iron (NTBI) by immortalized microglial (IMG) cells.	Iron	56-60	transferrin	Mus musculus	33-44
18393371-1	2008	UNLABELLED: HFE-related hereditary hemochromatosis results in hepatic iron overload.	Iron	70-74	homeostatic iron regulator	Mus musculus	12-15
18393371-2	2008	Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated).	Iron	38-42	transferrin	Mus musculus	20-31
18393371-2	2008	Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated).	Iron	38-42	transferrin receptor 2	Mus musculus	116-120
18393371-3	2008	In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by these pathways was investigated using Hfe knockout mice.	Iron	78-82	homeostatic iron regulator	Mus musculus	27-30
29610278-3	2018	SdhABCD contains the SDHA protein harboring a covalently bound FAD redox center and the iron-sulfur protein SDHB, containing three distinct iron-sulfur centers.	Iron	88-92	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	108-112
18393371-3	2008	In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by these pathways was investigated using Hfe knockout mice.	Iron	78-82	transferrin	Mus musculus	60-71
18393371-6	2008	Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression.	Iron	14-18	homeostatic iron regulator	Mus musculus	45-48
29610278-3	2018	SdhABCD contains the SDHA protein harboring a covalently bound FAD redox center and the iron-sulfur protein SDHB, containing three distinct iron-sulfur centers.	Iron	140-144	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	108-112
18393371-6	2008	Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression.	Iron	113-117	homeostatic iron regulator	Mus musculus	45-48
18393371-6	2008	Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression.	Iron	113-117	homeostatic iron regulator	Mus musculus	45-48
18393371-9	2008	CONCLUSION: Tfr1-mediated iron uptake is regulated by Hfe in hepatocytes.	Iron	26-30	homeostatic iron regulator	Mus musculus	54-57
29771935-5	2018	Under LPS-induced inflammatory conditions, low iron diet exacerbated the proinflammatory response, while the IL-12/IL-10 balance decreased with iron-rich diet, thus polarizing toward type 2 response.	Iron	144-148	interleukin 10	Homo sapiens	115-120
18334245-5	2008	This relationship may provide a link between VDR alleles and iron and nutritional markers, which are highly predictive variables of cardiovascular morbidity and mortality in hemodialysis patients.	Iron	61-65	vitamin D receptor	Homo sapiens	45-48
29771984-10	2018	However, HAMP mRNA expression in Huh7 was increased by AZA treatment, suggesting that methylation of one or more iron sensing genes may indirectly influence HAMP expression.	Iron	113-117	MIR7-3 host gene	Homo sapiens	33-37
29748478-1	2018	Arabidopsis thaliana natural resistance-associated macrophage protein 3 (AtNRAMP3) is involved in the transport of cadmium (Cd), iron (Fe), and manganese (Mn).	Iron	129-133	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	21-71
18305211-0	2008	Iron-induced turnover of the Arabidopsis IRON-REGULATED TRANSPORTER1 metal transporter requires lysine residues.	Iron	0-4	iron-regulated transporter 1	Arabidopsis thaliana	41-68
18305211-3	2008	IRON-REGULATED TRANSPORTER1 (IRT1) is the major high affinity iron transporter responsible for iron uptake from the soil in Arabidopsis (Arabidopsis thaliana).	Iron	62-66	iron-regulated transporter 1	Arabidopsis thaliana	0-27
18305211-3	2008	IRON-REGULATED TRANSPORTER1 (IRT1) is the major high affinity iron transporter responsible for iron uptake from the soil in Arabidopsis (Arabidopsis thaliana).	Iron	62-66	iron-regulated transporter 1	Arabidopsis thaliana	29-33
18305211-4	2008	Previously, we showed that IRT1 is subject to posttranscriptional regulation; when expressed from the constitutive cauliflower mosaic virus 35S promoter, IRT1 protein accumulates only in iron-deficient roots.	Iron	187-191	iron-regulated transporter 1	Arabidopsis thaliana	27-31
18305211-4	2008	Previously, we showed that IRT1 is subject to posttranscriptional regulation; when expressed from the constitutive cauliflower mosaic virus 35S promoter, IRT1 protein accumulates only in iron-deficient roots.	Iron	187-191	iron-regulated transporter 1	Arabidopsis thaliana	154-158
29748478-1	2018	Arabidopsis thaliana natural resistance-associated macrophage protein 3 (AtNRAMP3) is involved in the transport of cadmium (Cd), iron (Fe), and manganese (Mn).	Iron	129-133	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	73-81
18061239-6	2008	Experiments with composites based on Fe(0)/alpha-Fe2O3, Fe(0)/gamma-Fe2O3 and Fe(0)/FeOOH showed very low activities, suggesting that Fe(oct)2+ in the magnetite structure plays an important role in the reaction.	Iron	37-39	POU class 2 homeobox 2	Homo sapiens	134-142
29748478-1	2018	Arabidopsis thaliana natural resistance-associated macrophage protein 3 (AtNRAMP3) is involved in the transport of cadmium (Cd), iron (Fe), and manganese (Mn).	Iron	135-137	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	21-71
18061239-6	2008	Experiments with composites based on Fe(0)/alpha-Fe2O3, Fe(0)/gamma-Fe2O3 and Fe(0)/FeOOH showed very low activities, suggesting that Fe(oct)2+ in the magnetite structure plays an important role in the reaction.	Iron	37-42	POU class 2 homeobox 2	Homo sapiens	134-142
18061239-6	2008	Experiments with composites based on Fe(0)/alpha-Fe2O3, Fe(0)/gamma-Fe2O3 and Fe(0)/FeOOH showed very low activities, suggesting that Fe(oct)2+ in the magnetite structure plays an important role in the reaction.	Iron	56-61	POU class 2 homeobox 2	Homo sapiens	134-142
29748478-1	2018	Arabidopsis thaliana natural resistance-associated macrophage protein 3 (AtNRAMP3) is involved in the transport of cadmium (Cd), iron (Fe), and manganese (Mn).	Iron	135-137	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	73-81
18061239-8	2008	The high efficiency of the composite Fe(0)/Fe3O4 for Cr(VI) reduction is discussed in terms of a special mechanism where an electron is transferred from Fe(0) to magnetite to reduce Fe(oct)3+ to Fe(oct)2+, which is active for Cr(VI) reduction.	Iron	37-42	POU class 2 homeobox 2	Homo sapiens	195-203
29740119-6	2018	Log-transformed FGF23 significantly correlated with hepcidin but inversely correlated with iron profiles and hemoglobin.	Iron	91-95	fibroblast growth factor 23	Homo sapiens	16-21
17981932-11	2008	Importantly, the maintenance of divalent metal transporter-1 protein expression into old age could play a role in the accumulation of skeletal muscle iron.	Iron	150-154	RoBo-1	Rattus norvegicus	32-60
29113455-3	2018	To discover potential epigenetic modulator in hepcidin upregulation and subsequently decreasing iron burden, we performed an epigenetic screen.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	46-54
17895910-1	2008	Lipocalin 2 (LCN2) is able to sequester iron-loaded bacterial siderophores and, therefore, is known to participate in the mammalian innate immune response.	Iron	40-44	lipocalin 2	Homo sapiens	0-11
29113455-7	2018	Notably, the long-term treatment with entinostat in Hfe-/- mice significantly alleviated iron overload through upregulating hepcidin transcription.	Iron	89-93	homeostatic iron regulator	Mus musculus	52-55
17895910-1	2008	Lipocalin 2 (LCN2) is able to sequester iron-loaded bacterial siderophores and, therefore, is known to participate in the mammalian innate immune response.	Iron	40-44	lipocalin 2	Homo sapiens	13-17
29604179-1	2018	In the yeast Saccharomyces cerevisiae Aft1, the low iron-sensing transcription factor is known to regulate the expression of the FET3 gene.	Iron	52-56	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	38-42
18160403-8	2008	The FTL IRE is the primary responder in the presence of an iron donor in hypoxic conditions, and this response is reflected in endogenous FTL protein levels.	Iron	59-63	ferritin light chain	Homo sapiens	4-7
18160403-8	2008	The FTL IRE is the primary responder in the presence of an iron donor in hypoxic conditions, and this response is reflected in endogenous FTL protein levels.	Iron	59-63	ferritin light chain	Homo sapiens	138-141
18160403-9	2008	These results provide evidence that FTL and FTH subunits respond independently to cellular iron concentrations and underscore the importance of evaluating FTL and FTH IREs separately.	Iron	91-95	ferritin light chain	Homo sapiens	36-39
29604179-5	2018	We suggest that the activation of FET3 by Ace1 prevents the hyper activation of Aft1, possibly by assuring the adequate functioning of mitochondrial iron-sulfur cluster biogenesis.	Iron	149-153	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	80-84
18079412-7	2008	In cells treated with endothelin receptor antagonists, hydrogen peroxide scavengers, or an iron chelator, we identified, via mass spectrometry, proteins that are carbonylated in a receptor- and Fenton reaction-dependent manner, including annexin A1, which promotes apoptosis and suppresses cell growth.	Iron	91-95	annexin A1	Homo sapiens	238-248
29604179-6	2018	While reinforcing the link between iron and copper homeostasis, this work unveils a novel protection mechanism against copper toxicity mediated by Ace1, which relies in the activation of FET3 and results in the restriction of Aft1 activity as a means to prevent excessive copper accumulation.	Iron	35-39	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	226-230
29452354-0	2018	Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson"s disease.	Iron	72-76	Snx3p	Saccharomyces cerevisiae S288C	25-29
17868487-8	2008	After receiving Fe supplements, the levels of sTfR were significantly decreased in women of childbearing age with IDE and IDA, while the levels of serum ferritin were significantly increased.	Iron	16-18	insulin degrading enzyme	Homo sapiens	114-117
29452354-1	2018	We probed the role of alpha-synuclein (alpha-syn) in modulating sorting nexin 3 (Snx3)-retromer-mediated recycling of iron transporters in Saccharomyces cerevisiae and Caenorhabditis elegans.	Iron	118-122	Snx3p	Saccharomyces cerevisiae S288C	64-79
29452354-1	2018	We probed the role of alpha-synuclein (alpha-syn) in modulating sorting nexin 3 (Snx3)-retromer-mediated recycling of iron transporters in Saccharomyces cerevisiae and Caenorhabditis elegans.	Iron	118-122	Snx3p	Saccharomyces cerevisiae S288C	81-85
29452354-2	2018	In yeast, the membrane-bound heterodimer Fet3/Ftr1 is the high affinity iron importer.	Iron	72-76	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	46-50
17719830-4	2008	Our objective was to evaluate the effect of bone marrow transplantation from wild type mice on the status of iron overload in Hfe knockout hemochromatotic mice (Hfe(-/-)).	Iron	109-113	homeostatic iron regulator	Mus musculus	126-129
29452354-4	2018	When the concentration of external iron is low (<1 microM), Fet3/Ftr1 is maintained on the plasma membrane by retrograde endocytic-recycling; whereas, when the concentration of external iron is high (>10 microM), Fet3/Ftr1 is endocytosed and shunted to the vacuole for degradation.	Iron	35-39	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	65-69
17719830-7	2008	The iron content in the Hfe(-/-) mice descended 2.9-fold in the liver and 2.4-fold in the duodenum 6 months after transplantation.	Iron	4-8	homeostatic iron regulator	Mus musculus	24-27
17719830-8	2008	Non-significant changes of relative mRNA abundance of genes of iron metabolism were observed in the liver and duodenum of Hfe(-/-) transplanted mice.	Iron	63-67	homeostatic iron regulator	Mus musculus	122-125
29436580-6	2018	Iron-deficient cells exhibited morphological abnormalities and demonstrated a significant increase in the expression of Atrogin-1 (P&lt;0.05) and MuRF1 (P&lt;0.05) both in normoxia and hypoxia, which indicated activation of the ubiquitin proteasome pathway associated with protein degradation during muscle atrophy.	Iron	0-4	F-box protein 32	Homo sapiens	120-129
29436580-10	2018	Notably, in hypoxia, an increased expression of Atrogin-1 and MuRF1 was associated with an increased expression of transferrin receptor 1, reflecting intracellular iron demand (R=0.76, P&lt;0.01; R=0.86, P&lt;0.01).	Iron	164-168	F-box protein 32	Homo sapiens	48-57
29563156-0	2018	Hepcidin is an endogenous protective factor for osteoporosis by reducing iron levels.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	0-8
18772308-10	2008	This increase was associated with a decreased transcript level of the iron transporter IRT1, indicative of a more efficient transport of iron in the absence of Mn.	Iron	70-74	iron-regulated transporter 1	Arabidopsis thaliana	87-91
29563156-3	2018	In previous reports, we and others proposed that iron accumulation after menopause accelerates osteoporosis, and here, we genetically modified the expression of an endogenous hormone, hepcidin, to modulate iron status in a mouse model.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	184-192
18245906-5	2008	RESULTS: In the iron overload group, the levels of SI increased by 377.86%, the saturation of transferrin increased by 121.98% and the levels of iron in the liver increased by 2,548.15% (P&lt;0.01).	Iron	16-20	transferrin	Mus musculus	94-105
29563156-3	2018	In previous reports, we and others proposed that iron accumulation after menopause accelerates osteoporosis, and here, we genetically modified the expression of an endogenous hormone, hepcidin, to modulate iron status in a mouse model.	Iron	206-210	hepcidin antimicrobial peptide	Mus musculus	184-192
29626156-0	2018	The Gcn2-eIF2alpha pathway connects iron and amino acid homeostasis in Saccharomyces cerevisiae.	Iron	36-40	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	4-8
17471497-0	2007	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1.	Iron	38-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	168-172
29620856-0	2018	A Bottle-around-a-Ship Method To Generate Hollow Thin-Shelled Particles Containing Encapsulated Iron Species with Application to the Environmental Decontamination of Chlorinated Compounds.	Iron	96-100	inositol polyphosphate-5-phosphatase D	Homo sapiens	18-22
17644369-0	2007	Haptoglobin is degraded by iron in C57BL/6 mice: a possible link with endoplasmic reticulum stress.	Iron	27-31	haptoglobin	Mus musculus	0-11
17644369-2	2007	Haptoglobin, by virtue of its high affinity for hemoglobin, protects the tissues against hemoglobin-induced oxidative damage and allows heme iron recycling.	Iron	141-145	haptoglobin	Mus musculus	0-11
17644369-4	2007	Haptoglobin regulation in C57BL/6 and 129sv mice fed on an iron-rich diet for 3 weeks was thus undertaken.	Iron	59-63	haptoglobin	Mus musculus	0-11
17644369-5	2007	RESULTS: Iron induced a dramatic post-transcriptional decrease of liver and serum haptoglobin in C57BL/6 mice.	Iron	9-13	haptoglobin	Mus musculus	82-93
29755357-2	2018	In addition, LCN2 limits bacterial growth by sequestering iron-containing siderophores and further protects against intestinal inflammation and tumorigenesis associated with alterations in the microbiota.	Iron	58-62	lipocalin 2	Homo sapiens	13-17
17644369-7	2007	We assumed that the oxidative stress induced by iron in C57BL/6 mice altered the endoplasmic reticulum (ER) environment, leading to the incorrect folding of haptoglobin and its subsequent degradation.	Iron	48-52	haptoglobin	Mus musculus	157-168
17644369-12	2007	CONCLUSION: Our data demonstrate that iron regulates haptoglobin synthesis in C57BL/6 mice and suggest a possible link with iron-induced ER stress.	Iron	38-42	haptoglobin	Mus musculus	53-64
17644736-0	2007	The distal location of the iron responsive region of the hepcidin promoter.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	57-65
17644736-1	2007	The response of hepcidin transcription to iron has been repeatedly documented in living mice, but it is difficult to demonstrate the response in ex vivo systems.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	16-24
17644736-3	2007	This method enabled us to quantitate the response of the hepcidin promoter to short-term feeding of a high-iron diet to mice that have been maintained on an iron-deficient diet.	Iron	107-111	hepcidin antimicrobial peptide	Mus musculus	57-65
29900322-2	2018	The main goal of this study was to evaluate the human health risk assessment posed by high fluoride and iron concentration in tap water used for domestic activities and consumption.	Iron	104-108	nuclear RNA export factor 1	Homo sapiens	126-129
17644736-3	2007	This method enabled us to quantitate the response of the hepcidin promoter to short-term feeding of a high-iron diet to mice that have been maintained on an iron-deficient diet.	Iron	157-161	hepcidin antimicrobial peptide	Mus musculus	57-65
17766154-2	2007	LfR has been suggested to play a key role in the internalization of lactoferrin (Lf) and to facilitate absorption of iron bound to Lf.	Iron	117-121	lactoferrin receptor	Sus scrofa	0-3
29673159-1	2018	Efficient and general protocols for the O-tert-boc protection and O-arylation of phenols were developed in this paper using a recyclable magnetic Fe3O4-Co3O4 nanocatalyst (Nano-Fe-Co), which is easily accessible via simple wet impregnation techniques in aqueous mediums from inexpensive precursors.	Iron	146-148	BOC cell adhesion associated, oncogene regulated	Homo sapiens	47-50
17893044-8	2007	The doxorubicin-mediated decrease in cFLIP(S) and XIAP and the TRAIL-induced apoptosis were prevented by pretreatment with an iron chelator, indicating that expression of these proteins was affected by free radical generation upon interaction of iron with doxorubicin.	Iron	126-130	X-linked inhibitor of apoptosis	Homo sapiens	50-54
17951471-0	2007	Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells.	Iron	39-43	MIR7-3 host gene	Homo sapiens	75-79
29524511-1	2018	The yeast Saccharomyces cerevisiae monothiol glutaredoxin Grx3 plays a key role in cellular defense against oxidative stress and more importantly, cooperates with BolA-like iron repressor of activation protein Fra2 to regulate the localization of the iron-sensing transcription factor Aft2.	Iron	173-177	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	58-62
17851108-2	2007	Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis.	Iron	123-127	lysine demethylase 1A	Homo sapiens	188-192
29524511-1	2018	The yeast Saccharomyces cerevisiae monothiol glutaredoxin Grx3 plays a key role in cellular defense against oxidative stress and more importantly, cooperates with BolA-like iron repressor of activation protein Fra2 to regulate the localization of the iron-sensing transcription factor Aft2.	Iron	173-177	Bol2p	Saccharomyces cerevisiae S288C	210-214
29524511-1	2018	The yeast Saccharomyces cerevisiae monothiol glutaredoxin Grx3 plays a key role in cellular defense against oxidative stress and more importantly, cooperates with BolA-like iron repressor of activation protein Fra2 to regulate the localization of the iron-sensing transcription factor Aft2.	Iron	251-255	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	58-62
29524511-1	2018	The yeast Saccharomyces cerevisiae monothiol glutaredoxin Grx3 plays a key role in cellular defense against oxidative stress and more importantly, cooperates with BolA-like iron repressor of activation protein Fra2 to regulate the localization of the iron-sensing transcription factor Aft2.	Iron	251-255	Bol2p	Saccharomyces cerevisiae S288C	210-214
17908514-7	2007	All 3 had elevated iron levels but not a relevant HFE genotype.	Iron	19-23	paired box 5	Homo sapiens	0-5
29524511-2	2018	The interplay among Grx3, Fra2 and Aft2 responsible for the regulation of iron homeostasis has not been clearly described.	Iron	74-78	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	20-24
29524511-2	2018	The interplay among Grx3, Fra2 and Aft2 responsible for the regulation of iron homeostasis has not been clearly described.	Iron	74-78	Bol2p	Saccharomyces cerevisiae S288C	26-30
29524511-5	2018	NMR titration and pull-down assays combined with surface plasmon resonance experiments revealed that Fra2 could form a noncovalent heterodimer with Grx3 via an interface between the helix-turn-helix motif of Fra2 and the C-terminal segment of Grx3Grx, different from the previously identified covalent heterodimer mediated by Fe-S cluster.	Iron	326-330	Bol2p	Saccharomyces cerevisiae S288C	101-105
17609338-1	2007	Hepcidin is an antimicrobial peptide produced by the liver in response to inflammatory stimuli and iron overload.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	0-8
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	0-8
29524511-5	2018	NMR titration and pull-down assays combined with surface plasmon resonance experiments revealed that Fra2 could form a noncovalent heterodimer with Grx3 via an interface between the helix-turn-helix motif of Fra2 and the C-terminal segment of Grx3Grx, different from the previously identified covalent heterodimer mediated by Fe-S cluster.	Iron	326-330	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	148-152
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	0-8
29524511-7	2018	These structural and biochemical analyses enabled us to propose a model how Grx3 executes multiple functions to coordinate the regulation of Aft2-controlled iron metabolism.	Iron	157-161	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	76-80
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	0-8
17609338-2	2007	Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	0-8
29636509-2	2018	The hormone hepcidin stands out as a key regulator in the maintenance of iron homeostasis by controlling the main iron exporter, ferroportin.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	12-20
17609338-7	2007	Iron loading inhibited hepcidin mRNA expression induced by IFN-gamma and M. avium, and iron chelation increased hepcidin mRNA expression.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	23-31
17609338-7	2007	Iron loading inhibited hepcidin mRNA expression induced by IFN-gamma and M. avium, and iron chelation increased hepcidin mRNA expression.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	112-120
29636509-2	2018	The hormone hepcidin stands out as a key regulator in the maintenance of iron homeostasis by controlling the main iron exporter, ferroportin.	Iron	114-118	hepcidin antimicrobial peptide	Mus musculus	12-20
29636509-6	2018	Rescue experiments that block hepcidin up-regulation and restore iron levels in Tmprss6-/- mice via anti-hemojuvelin (HJV) therapy, revert the obesity-resistant phenotype of Tmprss6-/- mice.	Iron	65-69	hemojuvelin BMP co-receptor	Mus musculus	118-121
17927910-7	2007	The final three genes, NID-2, WDNMI, and ferritin, are involved in iron transport and extracellular protein inhibition.	Iron	67-71	nidogen 2	Bos taurus	23-28
17927936-5	2007	Afterwards a molecular study of the coding region for the IRE (iron responsive element) of the FTL gene was done by sequencing.	Iron	63-67	ferritin light chain	Homo sapiens	95-98
29175692-5	2018	Nitrate is a far more potent oxidant than sulfate, and thus, the NRB-assisted cracking of iron is a more thermodynamically favorable process than the SRB-assisted cracking.	Iron	90-94	chaperonin containing TCP1 subunit 4	Homo sapiens	150-153
17885134-2	2007	Spin states of iron in lower-mantle ferropericlase have been measured up to 95 gigapascals and 2000 kelvin with x-ray emission in a laser-heated diamond cell.	Iron	15-19	spindlin 1	Homo sapiens	0-4
17885134-3	2007	A gradual spin transition of iron occurs over a pressure-temperature range extending from about 1000 kilometers in depth and 1900 kelvin to 2200 kilometers and 2300 kelvin in the lower mantle.	Iron	29-33	spindlin 1	Homo sapiens	10-14
28992067-0	2018	The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	79-87
17452986-2	2007	The molecule is a member of the Tf superfamily and binds iron through a single high-affinity iron(III)-binding site.	Iron	57-61	transferrin	Mus musculus	32-34
17603005-3	2007	In this study, we report that expression of two essential components of the Fe-S machinery, the cysteine desulfurase Nfs1 and its scaffold protein partner IscU, is down-regulated at both mRNA and protein levels when murine macrophages are physiologically stimulated with IFN-gamma and LPS.	Iron	76-80	iron-sulfur cluster assembly enzyme	Mus musculus	155-159
17721544-9	2007	These results suggest that GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.	Iron	110-114	growth differentiation factor 15	Homo sapiens	27-32
28992067-1	2018	Background: Hepcidin secreted by hepatocytes is a key regulator of iron metabolism throughout the body.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	12-20
28992067-2	2018	Hepcidin concentrations are increased in chronic kidney disease (CKD), contributing to abnormalities in iron metabolism.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	0-8
28992067-17	2018	Conclusions: IS affects iron metabolism in CKD by participating in hepcidin regulation via pathways that depend on AhR and oxidative stress.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	67-75
17516080-10	2007	Split-root analyses using promoter-GUS lines showed that FIT and BHLH100 promoters were controlled by different local and systemic signals involved in their regulation by iron.	Iron	171-175	basic helix-loop-helix protein 100	Arabidopsis thaliana	65-72
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	137-141	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	16-23
29466854-4	2018	Here, we show that the spin states of iron atoms adsorbed directly on a conductive platinum substrate have a surprisingly long spin-relaxation time in the nanosecond regime, which is comparable to that of a transition metal atom decoupled from the substrate electrons by a thin decoupling layer.	Iron	38-42	spindlin 1	Homo sapiens	23-27
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	137-141	basic helix-loop-helix protein 100	Arabidopsis thaliana	34-41
29466854-4	2018	Here, we show that the spin states of iron atoms adsorbed directly on a conductive platinum substrate have a surprisingly long spin-relaxation time in the nanosecond regime, which is comparable to that of a transition metal atom decoupled from the substrate electrons by a thin decoupling layer.	Iron	38-42	spindlin 1	Homo sapiens	127-131
29438506-1	2018	Iron deprivation induces transcription of genes required for iron uptake, and transcription factor Aft1 and Aft2 mediate this by regulating transcriptional program in Saccharomyces cerevisiae.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	99-103
17685516-10	2007	The antibonding interaction involving the NS3 amine lone pair affords a relatively "stereochemically active" dz2 electron, the z direction being roughly along the Fe-N(NO) vector.	Iron	163-165	KRAS proto-oncogene, GTPase	Homo sapiens	42-45
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	89-93	cytosolic iron-sulfur assembly component 1	Homo sapiens	240-245
17555889-4	2007	Furthermore, our in vivo and in vitro studies show that Escherichia coli cells contain an enzymatic reducing system that keeps the heme iron atom of neuroglobin in the Fe(2+) form in the presence of dioxygen despite the high autoxidation rate of the molecule.	Iron	136-140	neuroglobin	Homo sapiens	149-160
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	89-93	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	258-263
29281120-0	2018	Iron Supplementation-Induced Phosphaturic Osteomalacia: FGF23 is the Culprit.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	56-61
17567778-0	2007	Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.	Iron	50-54	huntingtin	Danio rerio	0-10
17567778-9	2007	Since erythroid cells acquire iron via receptor-mediated endocytosis of transferrin, these results suggest a role for Htt in making endocytosed iron accessible for cellular utilization.	Iron	30-34	huntingtin	Danio rerio	118-121
17567778-9	2007	Since erythroid cells acquire iron via receptor-mediated endocytosis of transferrin, these results suggest a role for Htt in making endocytosed iron accessible for cellular utilization.	Iron	144-148	huntingtin	Danio rerio	118-121
17567778-11	2007	It is therefore plausible that perturbation of Htt"s normal role in the iron pathway (by polyglutamine tract expansion) contributes to HD pathology, and particularly to its neuronal specificity.	Iron	72-76	huntingtin	Danio rerio	47-50
29482530-6	2018	RESULTS: An iron restricted diet prevented development of the iron overload phenotype in mice with hepatocyte-specific Alk3 deficiency.	Iron	12-16	bone morphogenetic protein receptor, type 1A	Mus musculus	119-123
17701543-4	2007	In recent years, the molecular structures of Ngb with carbon monoxide bound to the heme iron and without an exogenous ligand have been solved, and interesting structural changes have been noticed upon ligand binding.	Iron	88-92	neuroglobin	Homo sapiens	45-48
29482530-6	2018	RESULTS: An iron restricted diet prevented development of the iron overload phenotype in mice with hepatocyte-specific Alk3 deficiency.	Iron	62-66	bone morphogenetic protein receptor, type 1A	Mus musculus	119-123
17538022-5	2007	Phosphorylation of S210 and S224 in Aft1p, which is not iron dependent, and the iron-induced intermolecular interaction of Aft1p are both essential for its recognition by Msn5p.	Iron	80-84	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	123-128
29402091-7	2018	Complete loss of cell viability was observed 72 h after MHT when the iron loading of the anti-CXCR4-functionalized particles was boosted by that of a nontargeted population.	Iron	69-73	C-X-C motif chemokine receptor 4	Homo sapiens	94-99
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	41-45	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	81-86
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	41-45	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	97-102
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	41-45	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	97-102
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	219-223	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	81-86
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	219-223	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	97-102
17538022-7	2007	Collectively, these results suggest that iron induces a conformational change in Aft1p, in which Aft1p Cys291 plays a critical role, and that, in turn, Aft1p is recognized by Msn5p and exported into the cytoplasm in an iron-dependent manner.	Iron	219-223	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	97-102
28636169-1	2018	PURPOSE: To present a novel Finnish double nucleotide variant in the iron-responsive element (IRE) of the ferritin L-chain gene (FTL) leading to hyperferritinaemia-cataract syndrome (HHCS).	Iron	69-73	ferritin light chain	Homo sapiens	106-122
17632513-0	2007	Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice.	Iron	79-83	MON1 homolog A, secretory traffciking associated	Mus musculus	21-26
17602574-2	2007	The active site coordination of CDO comprises a mononuclear iron ligated by the Nepsilon atoms of three protein-derived histidines, thus representing a new variant on the 2-histidine-1-carboxylate (2H1C) facial triad motif.	Iron	60-64	cysteine dioxygenase 1, cytosolic	Mus musculus	32-35
17602574-4	2007	In these experiments, CDO exhibits an ordered binding of l-cysteine prior to NO (and presumably O2) similar to that observed for the 2H1C class of non-heme iron enzymes.	Iron	156-160	cysteine dioxygenase 1, cytosolic	Mus musculus	22-25
17602574-7	2007	However, upon addition of NO to CDO in the presence of substrate l-cysteine, a low-spin {FeNO}7 (S = 1/2) signal that accounts for approximately 85% of the iron within the enzyme develops.	Iron	156-160	cysteine dioxygenase 1, cytosolic	Mus musculus	32-35
28636169-1	2018	PURPOSE: To present a novel Finnish double nucleotide variant in the iron-responsive element (IRE) of the ferritin L-chain gene (FTL) leading to hyperferritinaemia-cataract syndrome (HHCS).	Iron	69-73	ferritin light chain	Homo sapiens	129-132
17602574-13	2007	Moreover, the computed EPR parameters (g and A values) are in excellent agreement with experimental results for this CDO species and those obtained from comparable synthetic {FeNO}7 (S = 1/2) iron-nitrosyl complexes.	Iron	192-196	cysteine dioxygenase 1, cytosolic	Mus musculus	117-120
29391061-11	2018	Specifically, fundamental activities such as proliferation in response to iron exposure, L-ferritin expression in response to iron loading, secretion of BMP6 and cytokines, and migration and phagocytic activity were all found to be impacted by genotype.	Iron	126-130	ferritin light polypeptide 1	Mus musculus	89-99
17560557-2	2007	Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate proteins involved in iron homeostasis at the posttranscriptional level.	Iron	0-4	aconitase 1	Mus musculus	63-67
29391061-12	2018	Furthermore, we demonstrated that exposure to apo-Tf (iron-poor transferrin) can increase the release of iron from macrophages.	Iron	54-58	transferrin	Mus musculus	64-75
17560557-2	2007	Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate proteins involved in iron homeostasis at the posttranscriptional level.	Iron	0-4	iron responsive element binding protein 2	Mus musculus	72-76
17560557-2	2007	Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate proteins involved in iron homeostasis at the posttranscriptional level.	Iron	37-41	aconitase 1	Mus musculus	63-67
29159944-9	2018	All of the results suggest that iron might affect the growth of diatoms through the Calvin cycle and the cytochrome b6 /f complex.	Iron	32-36	petB	Phaeodactylum tricornutum	105-118
17560557-2	2007	Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate proteins involved in iron homeostasis at the posttranscriptional level.	Iron	37-41	iron responsive element binding protein 2	Mus musculus	72-76
17560557-2	2007	Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate proteins involved in iron homeostasis at the posttranscriptional level.	Iron	114-118	aconitase 1	Mus musculus	63-67
17560557-2	2007	Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate proteins involved in iron homeostasis at the posttranscriptional level.	Iron	114-118	iron responsive element binding protein 2	Mus musculus	72-76
17560557-6	2007	In contrast, an increase in loosely bound and a more pronounced increase in non-heme iron was seen in IRP2-/- mice between 6 and 12 weeks of age, stemming from lower levels at 6 weeks (the youngest age examined) compared to wildtype.	Iron	85-89	iron responsive element binding protein 2	Mus musculus	102-106
29232947-4	2018	We use a scanning tunneling microscope to trap a meso-substituted iron porphyrin, putting the iron center in an environment that provides control of its charge and spin states.	Iron	66-70	spindlin 1	Homo sapiens	164-168
17592141-0	2007	Enhanced plant tolerance to iron starvation by functional substitution of chloroplast ferredoxin with a bacterial flavodoxin.	Iron	28-32	ferredoxin	Nicotiana tabacum	86-96
29032057-0	2018	The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	27-32
29032057-2	2018	In budding yeast, the low-iron sensing transcription factor Aft1p is a master regulator of the iron regulon.	Iron	26-30	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	60-65
17499976-3	2007	Iron-sulfur (Fe/S) clusters are required in two enzymes of heme biosynthesis in humans i.e. in ferrochelatase and adrenodoxin.	Iron	13-15	ferrochelatase	Homo sapiens	95-109
29032057-2	2018	In budding yeast, the low-iron sensing transcription factor Aft1p is a master regulator of the iron regulon.	Iron	95-99	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	60-65
29032057-3	2018	Our previous work revealed that bioactive sphingolipids modulate iron homeostasis as yeast cells lacking the sphingomyelinase Isc1p exhibit an upregulation of the iron regulon.	Iron	65-69	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	126-131
29032057-4	2018	In this study, we show that Isc1p impacts on iron accumulation and localization.	Iron	45-49	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	28-33
17579362-2	2007	It is caused by mutations in the iron response element (IRE) of the Ferritin Light Chain (FTL) gene.	Iron	33-37	ferritin light chain	Homo sapiens	68-88
29032057-6	2018	Consistently, the expression of a phosphomimetic version of Aft1p-S210/S224 that favours its nuclear export abolished iron accumulation in isc1Delta cells.	Iron	118-122	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	60-65
17579362-2	2007	It is caused by mutations in the iron response element (IRE) of the Ferritin Light Chain (FTL) gene.	Iron	33-37	ferritin light chain	Homo sapiens	90-93
17486601-1	2007	An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte.	Iron	193-197	hephaestin	Homo sapiens	66-76
17486601-1	2007	An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte.	Iron	193-197	hephaestin	Homo sapiens	78-82
17607367-6	2007	The neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latter in an iron-dependent manner.	Iron	111-115	lipocalin 2	Homo sapiens	47-58
29032057-8	2018	However, Hog1p-Aft1p interaction decreases in isc1Delta cells, which likely contributes to Aft1p dephosphorylation and consequently to Aft1p activation and iron overload in isc1Delta cells.	Iron	156-160	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	15-20
30205391-0	2018	Long Non-Coding RNA PVT1/miR-150/ HIG2 Axis Regulates the Proliferation, Invasion and the Balance of Iron Metabolism of Hepatocellular Carcinoma.	Iron	101-105	microRNA 150	Homo sapiens	25-32
17630978-5	2007	Interestingly, a mutant lacking the Aft1 transcription factor, required for the transcriptional response to iron starvation, was found to be highly sensitive to zinc.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	36-40
30205391-14	2018	Moreover, inhibition of miR-150 could partly reverse the biological effects of PVT1 knockdown on proliferation, motility, apoptosis and iron metabolism in vitro, which might be associated with dysregulation of HIG2.	Iron	136-140	microRNA 150	Homo sapiens	24-31
17551769-1	2007	Tartrate-resistant acid phosphatase (TRAP) is an iron-containing protein that is highly expressed by osteoclasts, macrophages, and dendritic cells.	Iron	49-53	acid phosphatase 5, tartrate resistant	Mus musculus	0-35
17551769-1	2007	Tartrate-resistant acid phosphatase (TRAP) is an iron-containing protein that is highly expressed by osteoclasts, macrophages, and dendritic cells.	Iron	49-53	acid phosphatase 5, tartrate resistant	Mus musculus	37-41
29843136-13	2018	CONCLUSION: The present study provides new evidence that ASP decreases hepcidin expression, which can reduce iron burden and inhibit tumor proliferation.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	71-79
29111167-7	2018	Intracellular iron was down-regulated by hepcidin depending on IL-10.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	41-49
17449618-9	2007	As hmpA and ytfE encode a nitric oxide reductase and a mechanism to repair iron-sulfur centers damaged by nitric oxide, the demonstration that hcp-hcr, hmpA, and ytfE are the three transcripts most tightly regulated by NsrR highlights the possibility that the hybrid cluster protein, HCP, might also be part of a defense mechanism against reactive nitrogen stress.	Iron	75-79	nitric oxide dioxygenase	Escherichia coli str. K-12 substr. MG1655	3-7
29725502-9	2018	Therefore, the results suggest that CPX-induced degradation of Cdc25A is attributed to the activation of ATR-Chk1 signaling pathway, a consequence of iron chelation-induced DNA damage.	Iron	150-154	cell division cycle 25A	Homo sapiens	63-69
17469137-7	2007	Together, these results demonstrate that m-aconitase is an important target of Mn and thatMn-induced alteration of iron homeostasis is mediated predominantly through IRP2.	Iron	115-119	iron responsive element binding protein 2	Rattus norvegicus	166-170
29078150-2	2018	In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of the CD loop that strengthens the bond between the heme iron and the distal histidine.	Iron	224-228	neuroglobin	Homo sapiens	22-26
17091306-11	2007	Using the same approach, we noted a precipitous drop in fRET, and an elevation in fMN-RET within 48 h after 1 Gy of iron ions.	Iron	116-120	formin 1	Mus musculus	82-85
29746250-0	2018	Cellular Assays for Studying the Fe-S Cluster Containing Base Excision Repair Glycosylase MUTYH and Homologs.	Iron	33-37	mutY DNA glycosylase	Homo sapiens	90-95
29746250-1	2018	Many DNA repair enzymes, including the human adenine glycosylase MUTYH, require iron-sulfur (Fe-S) cluster cofactors for DNA damage recognition and subsequent repair.	Iron	93-97	mutY DNA glycosylase	Homo sapiens	65-70
29165807-5	2018	An irt1 null mutant was grown hydroponically in different conditions of Fe bioavailability and phosphate supply, and challenged with uranyl.	Iron	72-74	iron-regulated transporter 1	Arabidopsis thaliana	3-7
17359508-8	2007	A high FGF-23(post) level was independently associated with a high FE(PO4).	Iron	67-69	fibroblast growth factor 23	Homo sapiens	7-13
17331760-0	2007	In vivo imaging of hepcidin promoter stimulation by iron and inflammation.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	19-27
17331760-1	2007	Hepcidin is an acute-phase response antimicrobial peptide that has emerged as a central regulator of iron absorption.	Iron	101-105	hepcidin antimicrobial peptide	Mus musculus	0-8
28236581-8	2018	The highest percentage of TOC decay (37%) was obtained in a dual-frequency operation (40/572kHz) with ZVI, in which the energy consumption was neither low nor exceptionally too high.	Iron	102-105	rhomboid 5 homolog 2	Homo sapiens	26-29
17331760-2	2007	Circulating hepcidin levels have been shown to affect iron uptake, release and storage.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	12-20
17331760-4	2007	Hypoxia, erythroid demand, iron content and inflammation each have been shown to influence hepcidin mRNA expression in intact animals.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	91-99
17331760-5	2007	In vitro, regulation of hepcidin by cytokines and by hypoxia is readily demonstrated in primary hepatocytes or in hepatocyte lines, but incubating the same cell lines with iron does not increase transcription of hepcidin.	Iron	172-176	hepcidin antimicrobial peptide	Mus musculus	24-32
17331760-6	2007	Thus, how iron excess stimulates hepcidin production in hepatocytes remains unknown.	Iron	10-14	hepcidin antimicrobial peptide	Mus musculus	33-41
29091051-1	2017	Spin- and angle-resolved photoemission spectroscopy of thin Ag(1 1 1) films on ferromagnetic Fe(1 1 0) shows a series of spin-polarized peaks.	Iron	93-95	spindlin 1	Homo sapiens	0-4
29091051-1	2017	Spin- and angle-resolved photoemission spectroscopy of thin Ag(1 1 1) films on ferromagnetic Fe(1 1 0) shows a series of spin-polarized peaks.	Iron	93-95	spindlin 1	Homo sapiens	121-125
29619193-2	2017	It belongs to the widespread Rrf2 super-family of transcriptional regulators and features three conserved Cys residues that characterise the binding of an iron-sulfur cluster in other Rrf2 family regulators.	Iron	155-159	GTP dependent ribosome recycling factor mitochondrial 2	Homo sapiens	29-33
29619193-2	2017	It belongs to the widespread Rrf2 super-family of transcriptional regulators and features three conserved Cys residues that characterise the binding of an iron-sulfur cluster in other Rrf2 family regulators.	Iron	155-159	GTP dependent ribosome recycling factor mitochondrial 2	Homo sapiens	184-188
28774998-10	2017	Our results underline the strong relationship between iron and FGF23 physiology, and provide a potential mechanism explaining the relationship between ID and adverse outcome in RTRs.	Iron	54-58	fibroblast growth factor 23	Homo sapiens	63-68
29029193-0	2017	Sex and Iron Modify Fibroblast Growth Factor 23 Concentration in 1-Year-Old Children.	Iron	8-12	fibroblast growth factor 23	Homo sapiens	20-47
29029193-10	2017	The iron concentration was positively associated with intact FGF23 and was the strongest modifier of intact FGF23 (regression coefficient, 0.498; 95% confidence interval, 0.333 to 0.663; P &lt; 0.001) with ferritin, season, ionized calcium, 25OHD, and sex as other covariates.	Iron	4-8	fibroblast growth factor 23	Homo sapiens	61-66
29029193-10	2017	The iron concentration was positively associated with intact FGF23 and was the strongest modifier of intact FGF23 (regression coefficient, 0.498; 95% confidence interval, 0.333 to 0.663; P &lt; 0.001) with ferritin, season, ionized calcium, 25OHD, and sex as other covariates.	Iron	4-8	fibroblast growth factor 23	Homo sapiens	108-113
29029193-11	2017	The association between iron and C-terminal FGF23 was inversely related (regression coefficient, -0.072; 95% confidence interval, -0.092 to -0.051; P &lt; 0.001).	Iron	24-28	fibroblast growth factor 23	Homo sapiens	44-49
29029193-13	2017	Iron modified FGF23 concentrations, with intact FGF23 higher and C-terminal lower, in those with greater iron concentrations.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	14-19
29029193-13	2017	Iron modified FGF23 concentrations, with intact FGF23 higher and C-terminal lower, in those with greater iron concentrations.	Iron	105-109	fibroblast growth factor 23	Homo sapiens	14-19
27558654-0	2017	Oral iron supplementation with sodium ferrous citrate reduces the serum intact and c-terminal fibroblast growth factor 23 levels of maintenance haemodialysis patients.	Iron	5-9	fibroblast growth factor 23	Homo sapiens	94-121
27558654-2	2017	This study aimed to determine whether oral ferrous iron (Fe2+ ) reduces the serum FGF23 levels of iron-deficient maintenance haemodialysis (MHD) patients in the same way as oral ferric iron (Fe3+ ) METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study.	Iron	43-55	fibroblast growth factor 23	Homo sapiens	82-87
27558654-2	2017	This study aimed to determine whether oral ferrous iron (Fe2+ ) reduces the serum FGF23 levels of iron-deficient maintenance haemodialysis (MHD) patients in the same way as oral ferric iron (Fe3+ ) METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study.	Iron	51-55	fibroblast growth factor 23	Homo sapiens	82-87
29286823-0	2017	Switching Magnetism and Superconductivity with Spin-Polarized Current in Iron-Based Superconductor.	Iron	73-77	spindlin 1	Homo sapiens	47-51
29286823-1	2017	We explore a new mechanism for switching magnetism and superconductivity in a magnetically frustrated iron-based superconductor using spin-polarized scanning tunneling microscopy (SPSTM).	Iron	102-106	spindlin 1	Homo sapiens	134-138
29286823-5	2017	These results suggest a new possibility of switching local superconductivity by changing the symmetry of magnetic order with spin-polarized and unpolarized tunneling currents in iron-based superconductors.	Iron	178-182	spindlin 1	Homo sapiens	125-129
29170479-6	2017	Moreover, heme degradation products, except iron and N-acetylcysteine prevented H2O2-mediated miR-155-5p biogenesis and eNOS downregulation.	Iron	44-48	microRNA 155	Homo sapiens	94-101
29955721-12	2018	Conclusions: Elevated SCD activity may be associated with increased iron storage inside the human body; the association did not appear to be mediated via oxidative stress, as estimated by GGT levels.	Iron	68-72	stearoyl-CoA desaturase	Homo sapiens	22-25
29049878-5	2017	Across a number of model iron complexes, we observe strong exchange sensitivities of reaction barriers and energies that are of the same magnitude as those for spin splitting energies.	Iron	25-29	spindlin 1	Homo sapiens	160-164
29078383-6	2017	STEAP4 was regulated in a hypoxia-dependent manner that led to a dysregulation in mitochondrial iron balance, enhanced reactive oxygen species production, and increased susceptibility to mouse models of colitis.	Iron	96-100	STEAP family member 4	Mus musculus	0-6
28924039-12	2017	Moreover, iron-loaded transferrin blocked MT2-mediated Tfr2 cleavage, providing further insights into the mechanism of Tfr2"s regulation by transferrin.	Iron	10-14	transferrin	Mus musculus	22-33
28924039-12	2017	Moreover, iron-loaded transferrin blocked MT2-mediated Tfr2 cleavage, providing further insights into the mechanism of Tfr2"s regulation by transferrin.	Iron	10-14	transferrin receptor 2	Mus musculus	55-59
28924039-12	2017	Moreover, iron-loaded transferrin blocked MT2-mediated Tfr2 cleavage, providing further insights into the mechanism of Tfr2"s regulation by transferrin.	Iron	10-14	transferrin receptor 2	Mus musculus	119-123
28924039-12	2017	Moreover, iron-loaded transferrin blocked MT2-mediated Tfr2 cleavage, providing further insights into the mechanism of Tfr2"s regulation by transferrin.	Iron	10-14	transferrin	Mus musculus	140-151
28815688-1	2017	Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
28815688-1	2017	Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	0-8
28815688-1	2017	Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	0-8
28815688-1	2017	Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	0-8
28815688-2	2017	The bone morphogenetic protein (BMP)-SMAD signaling pathway, through the ligand BMP6 and the co-receptor hemojuvelin, is a central regulator of hepcidin transcription in the liver in response to iron.	Iron	195-199	hepcidin antimicrobial peptide	Mus musculus	144-152
28815688-3	2017	Here, we show that dietary iron loading has a residual ability to induce Smad signaling and hepcidin expression in Bmp6-/- mice, effects that are blocked by a neutralizing BMP2/4 antibody.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	92-100
28815688-7	2017	Together, these data demonstrate that in addition to BMP6, endothelial cell BMP2 has a non-redundant role in hepcidin regulation by iron.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	109-117
29038973-12	2017	The dehydratase activity was significantly improved by targeting its expression to mitochondria or by altering the Fe-S cluster metabolism of the cells with FRA2 deletion.	Iron	115-119	Bol2p	Saccharomyces cerevisiae S288C	157-161
28754384-10	2017	The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 complex shown in this work may be important for the characterization of the mechanism of ferritinophagy.	Iron	4-8	nuclear receptor coactivator 4	Homo sapiens	82-87
29125827-1	2017	Friedreich ataxia (FRDA), the most common recessive inherited ataxia, results from deficiency of frataxin, a small mitochondrial protein crucial for iron-sulphur cluster formation and ATP production.	Iron	149-153	frataxin	Mus musculus	0-17
29125827-1	2017	Friedreich ataxia (FRDA), the most common recessive inherited ataxia, results from deficiency of frataxin, a small mitochondrial protein crucial for iron-sulphur cluster formation and ATP production.	Iron	149-153	frataxin	Mus musculus	97-105
28678636-3	2017	The degree of iron loading has previously been associated with certain HLA-types and with abnormally low CD8 + cell counts in peripheral blood.	Iron	14-18	CD8a molecule	Homo sapiens	105-108
17331760-7	2007	In addition, there is no current technique available that can investigate how iron induces hepcidin expression.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	91-99
28678636-7	2017	In p.C282Y homozygous individuals, the iron loading was increased if the CD8 + cell number was below the 25 percentile or if the CD4 + cell number was above the 75 percentile.	Iron	39-43	CD8a molecule	Homo sapiens	73-76
17331760-9	2007	Transfected hepcidin promoter constructs were shown to respond to both inflammatory and iron stimuli in vivo.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	12-20
28678636-10	2017	In addition, low CD8 + cell number or high CD4 + cell number further increases the risk of excessive iron loading.	Iron	101-105	CD8a molecule	Homo sapiens	17-20
28732942-4	2017	The results showed that the optimal conditions predicted by the model without defining any restrictions are: pH=2.0, Po=120W, ZVI=24mgL-1, which provide total salicyclic acid and 48% TOC decay.	Iron	126-129	LLGL scribble cell polarity complex component 1	Homo sapiens	132-137
17331760-10	2007	This work highlights the ability of this new imaging technique to investigate the key regions of the hepcidin promoter involved in iron induction of hepcidin expression.	Iron	131-135	hepcidin antimicrobial peptide	Mus musculus	101-109
17331760-10	2007	This work highlights the ability of this new imaging technique to investigate the key regions of the hepcidin promoter involved in iron induction of hepcidin expression.	Iron	131-135	hepcidin antimicrobial peptide	Mus musculus	149-157
29163381-8	2017	In addition to results similar to those reported for other bacteria, our findings demonstrate that Hfq is required in the regulation of the iron-acquisition system via downregulating the bauA and basD genes, the stress-related outer membrane proteins carO, A1S_0820, ompA, and nlpE, and the stress-related cytosolic proteins uspA and groEL.	Iron	140-144	universal stress protein A	Acinetobacter baumannii	325-329
17497534-4	2007	The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression.	Iron	51-55	RoBo-1	Rattus norvegicus	4-32
17497534-4	2007	The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression.	Iron	51-55	RoBo-1	Rattus norvegicus	34-38
17497534-4	2007	The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression.	Iron	123-127	RoBo-1	Rattus norvegicus	4-32
17497534-4	2007	The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression.	Iron	123-127	RoBo-1	Rattus norvegicus	34-38
17497534-4	2007	The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression.	Iron	123-127	RoBo-1	Rattus norvegicus	151-155
17497534-6	2007	The feeding of an iron-deficient diet for 4 wk produced a depletion of body iron, such as decreased iron levels in the serum and tissues, and upregulated the DMT1 expression in the rat duodenum.	Iron	18-22	RoBo-1	Rattus norvegicus	158-162
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	72-76	cytochrome b reductase 1	Homo sapiens	162-183
17331953-0	2007	Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.	Iron	64-68	neogenin 1	Homo sapiens	89-97
29063108-4	2017	HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR).	Iron	72-76	cytochrome b reductase 1	Homo sapiens	185-190
27729173-7	2017	RESULTS: In samples that had not been exposed to hepcidin, correlations were found between the expression of genes involved in iron absorption: DMT1, Fpn1, Dcytb and HCP1.	Iron	127-131	cytochrome b reductase 1	Homo sapiens	156-161
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	101-105	cytochrome b reductase 1	Homo sapiens	169-174
17420293-2	2007	Endocytic sorting of the yeast reductive iron transporter, which is composed of the Fet3 and Ftr1 proteins, is regulated by available iron.	Iron	41-45	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	93-97
17420293-3	2007	When iron is provided to iron-starved cells, Fet3p-Ftr1p is targeted to the lysosome-like vacuole and degraded.	Iron	5-9	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	51-56
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	161-165	cytochrome b reductase 1	Homo sapiens	169-174
17420293-3	2007	When iron is provided to iron-starved cells, Fet3p-Ftr1p is targeted to the lysosome-like vacuole and degraded.	Iron	25-29	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	51-56
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	161-165	cytochrome b reductase 1	Homo sapiens	169-174
17420293-4	2007	In contrast, when iron is not available, Fet3p-Ftr1p is maintained on the plasma membrane via an endocytic recycling pathway requiring the sorting nexin Grd19/Snx3p, the pentameric retromer complex, and the Ypt6p Golgi Rab GTPase module.	Iron	18-22	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	47-52
27729173-9	2017	CONCLUSIONS: Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.	Iron	161-165	cytochrome b reductase 1	Homo sapiens	169-174
28506129-7	2017	After 3 months of oral iron treatment, there was a significant improvement (decrease) in urinary NGAL and L-FABP in infants and children with IDA.	Iron	23-27	lipocalin 2	Homo sapiens	97-101
17427814-5	2007	A mutant knock-out iron transporter IRT1 showed lower iron and chlorophyll contents when supplemented with Fe-EDTA than the wild type but not when supplemented with Fe-pyoverdine, indicating that, in contrast to iron from EDTA, iron from pyoverdine was not incorporated through the IRT1 transporter.	Iron	19-23	iron-regulated transporter 1	Arabidopsis thaliana	36-40
17427814-5	2007	A mutant knock-out iron transporter IRT1 showed lower iron and chlorophyll contents when supplemented with Fe-EDTA than the wild type but not when supplemented with Fe-pyoverdine, indicating that, in contrast to iron from EDTA, iron from pyoverdine was not incorporated through the IRT1 transporter.	Iron	19-23	iron-regulated transporter 1	Arabidopsis thaliana	282-286
17427814-5	2007	A mutant knock-out iron transporter IRT1 showed lower iron and chlorophyll contents when supplemented with Fe-EDTA than the wild type but not when supplemented with Fe-pyoverdine, indicating that, in contrast to iron from EDTA, iron from pyoverdine was not incorporated through the IRT1 transporter.	Iron	54-58	iron-regulated transporter 1	Arabidopsis thaliana	36-40
17427814-5	2007	A mutant knock-out iron transporter IRT1 showed lower iron and chlorophyll contents when supplemented with Fe-EDTA than the wild type but not when supplemented with Fe-pyoverdine, indicating that, in contrast to iron from EDTA, iron from pyoverdine was not incorporated through the IRT1 transporter.	Iron	54-58	iron-regulated transporter 1	Arabidopsis thaliana	36-40
17293870-3	2007	DMT-1 mediates intracellular iron transport during the transferrin cycle and apical iron absorption in the duodenum.	Iron	29-33	transferrin	Mus musculus	55-66
28808058-2	2017	Reductions in Abcb10 levels have been shown to reduce mitoferrin1 protein levels and iron import into mitochondria, resulting in reduced heme biosynthesis.	Iron	85-89	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	14-20
17215245-11	2007	Microarray analysis comparing wild-type and vma2Delta mutant cells grown at pH 5, permissive conditions for the vma2Delta mutant, indicated high level up-regulation of several iron uptake and metabolism genes that are part of the Aft1/Aft2 regulon.	Iron	176-180	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	230-234
17453917-0	2007	Molecular chaperones HscA/Ssq1 and HscB/Jac1 and their roles in iron-sulfur protein maturation.	Iron	64-68	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	40-44
28678017-1	2017	Ultrafast spin currents induced by femtosecond laser excitation of ferromagnetic metals have been found to contribute to sub-picosecond demagnetization, and to cause a transient enhancement of the magnetization of the bottom Fe layer in a Ni/Ru/Fe layered structure.	Iron	225-227	spindlin 1	Homo sapiens	10-14
28678017-1	2017	Ultrafast spin currents induced by femtosecond laser excitation of ferromagnetic metals have been found to contribute to sub-picosecond demagnetization, and to cause a transient enhancement of the magnetization of the bottom Fe layer in a Ni/Ru/Fe layered structure.	Iron	245-247	spindlin 1	Homo sapiens	10-14
17261801-1	2007	Ferrochelatase, the terminal enzyme in heme biosynthesis, catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.	Iron	93-97	ferrochelatase	Homo sapiens	0-14
28678017-4	2017	In the latter, the spin-scattering Ta layer suppresses spin currents from the Ni layer into Fe, consistent with previous results.	Iron	92-94	spindlin 1	Homo sapiens	19-23
28678017-4	2017	In the latter, the spin-scattering Ta layer suppresses spin currents from the Ni layer into Fe, consistent with previous results.	Iron	92-94	spindlin 1	Homo sapiens	55-59
17358310-1	2007	In this study, the relaxation dynamics of iron-group dihalides by making use of spin- 1/2 metamagnetic Ising model has been formulated by the method of thermodynamics of irreversible processes.	Iron	42-46	spindlin 1	Homo sapiens	80-89
28678017-5	2017	Any spin current arriving in the lower Fe layer will counteract other, local demagnetization mechanisms such as phonon-mediated spin-flip scattering.	Iron	39-41	spindlin 1	Homo sapiens	4-8
28678017-5	2017	Any spin current arriving in the lower Fe layer will counteract other, local demagnetization mechanisms such as phonon-mediated spin-flip scattering.	Iron	39-41	spindlin 1	Homo sapiens	128-132
28678017-6	2017	We find by increasing the Ni and Fe layer thicknesses in Ni/Ru/Fe a decreasing effect of spin currents on the buried Fe layer, consistent with a mean free path of the laser-induced spin currents of just a few nm.	Iron	33-35	spindlin 1	Homo sapiens	89-93
17207112-2	2007	The liver-derived peptide hepcidin is the central regulator of iron homeostasis and recent animal studies have demonstrated that exposure to alcohol reduces hepcidin expression.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	26-34
28678017-6	2017	We find by increasing the Ni and Fe layer thicknesses in Ni/Ru/Fe a decreasing effect of spin currents on the buried Fe layer, consistent with a mean free path of the laser-induced spin currents of just a few nm.	Iron	33-35	spindlin 1	Homo sapiens	181-185
17207112-3	2007	This down-regulation of hepcidin in vivo implies that disturbed iron sensing may contribute to the hepatosiderosis seen in alcoholic liver disease.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	24-32
17207112-12	2007	In an alcohol-susceptible strain, mutation of the Hfe gene diminished the response of the measured iron indices to alcohol treatment.	Iron	99-103	homeostatic iron regulator	Mus musculus	50-53
28678017-6	2017	We find by increasing the Ni and Fe layer thicknesses in Ni/Ru/Fe a decreasing effect of spin currents on the buried Fe layer, consistent with a mean free path of the laser-induced spin currents of just a few nm.	Iron	63-65	spindlin 1	Homo sapiens	89-93
17207112-13	2007	This indicates that either maximal suppression of hepcidin levels had already occurred as a result of the Hfe mutation or that Hfe was a component of the pathway utilized by EtOH in suppressing hepcidin production and increasing iron absorption.	Iron	229-233	homeostatic iron regulator	Mus musculus	127-130
28678017-6	2017	We find by increasing the Ni and Fe layer thicknesses in Ni/Ru/Fe a decreasing effect of spin currents on the buried Fe layer, consistent with a mean free path of the laser-induced spin currents of just a few nm.	Iron	63-65	spindlin 1	Homo sapiens	181-185
28678017-6	2017	We find by increasing the Ni and Fe layer thicknesses in Ni/Ru/Fe a decreasing effect of spin currents on the buried Fe layer, consistent with a mean free path of the laser-induced spin currents of just a few nm.	Iron	63-65	spindlin 1	Homo sapiens	89-93
28678017-6	2017	We find by increasing the Ni and Fe layer thicknesses in Ni/Ru/Fe a decreasing effect of spin currents on the buried Fe layer, consistent with a mean free path of the laser-induced spin currents of just a few nm.	Iron	63-65	spindlin 1	Homo sapiens	181-185
16935854-0	2007	Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3.	Iron	0-4	transferrin receptor 2	Mus musculus	59-81
28390898-4	2017	In this study, the levels of the ethylene response factor AtERF72 increased in leaves and roots induced under the iron deficient conditions.	Iron	114-118	ethylene-responsive element binding protein	Arabidopsis thaliana	58-65
16935854-0	2007	Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3.	Iron	28-32	transferrin receptor 2	Mus musculus	59-81
16935854-1	2007	Hereditary hemochromatosis type 3 is an iron (Fe)-overload disorder caused by mutations in transferrin receptor 2 (TfR2).	Iron	40-44	transferrin receptor 2	Mus musculus	91-113
16935854-1	2007	Hereditary hemochromatosis type 3 is an iron (Fe)-overload disorder caused by mutations in transferrin receptor 2 (TfR2).	Iron	40-44	transferrin receptor 2	Mus musculus	115-119
16935854-1	2007	Hereditary hemochromatosis type 3 is an iron (Fe)-overload disorder caused by mutations in transferrin receptor 2 (TfR2).	Iron	46-48	transferrin receptor 2	Mus musculus	91-113
16935854-1	2007	Hereditary hemochromatosis type 3 is an iron (Fe)-overload disorder caused by mutations in transferrin receptor 2 (TfR2).	Iron	46-48	transferrin receptor 2	Mus musculus	115-119
16935854-2	2007	TfR2 is expressed highly in the liver and regulates Fe metabolism.	Iron	52-54	transferrin receptor 2	Mus musculus	0-4
28390898-5	2017	erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d. erf72 mutants had increased root H+ velocity and the ferric reductase activity, and increase in the expression of the iron deficiency response genes iron-regulated transporter 1 (IRT1) and H+-ATPase (HA2) levels in iron deficient conditions.	Iron	85-89	ethylene-responsive element binding protein	Arabidopsis thaliana	0-5
17726308-8	2007	Adequate intake of vitamins B(6), folate, B(12), C, E, and of selenium, zinc, copper, and iron supports a Th1 cytokine-mediated immune response with sufficient production of proinflammatory cytokines, which maintains an effective immune response and avoids a shift to an anti-inflammatory Th2 cell-mediated immune response and an increased risk of extracellular infections.	Iron	90-94	negative elongation factor complex member C/D	Homo sapiens	106-109
28390898-5	2017	erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d. erf72 mutants had increased root H+ velocity and the ferric reductase activity, and increase in the expression of the iron deficiency response genes iron-regulated transporter 1 (IRT1) and H+-ATPase (HA2) levels in iron deficient conditions.	Iron	234-238	ethylene-responsive element binding protein	Arabidopsis thaliana	0-5
28390898-5	2017	erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d. erf72 mutants had increased root H+ velocity and the ferric reductase activity, and increase in the expression of the iron deficiency response genes iron-regulated transporter 1 (IRT1) and H+-ATPase (HA2) levels in iron deficient conditions.	Iron	234-238	ethylene-responsive element binding protein	Arabidopsis thaliana	116-121
28390898-5	2017	erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d. erf72 mutants had increased root H+ velocity and the ferric reductase activity, and increase in the expression of the iron deficiency response genes iron-regulated transporter 1 (IRT1) and H+-ATPase (HA2) levels in iron deficient conditions.	Iron	234-238	ethylene-responsive element binding protein	Arabidopsis thaliana	0-5
18449360-1	2007	Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a lipocalin that is well known for its functions as a shuttle for iron and siderophores, which comprises a critical component of innate immunity to exogenous bacterial infections.	Iron	119-123	lipocalin 2	Homo sapiens	0-42
28390898-5	2017	erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d. erf72 mutants had increased root H+ velocity and the ferric reductase activity, and increase in the expression of the iron deficiency response genes iron-regulated transporter 1 (IRT1) and H+-ATPase (HA2) levels in iron deficient conditions.	Iron	234-238	ethylene-responsive element binding protein	Arabidopsis thaliana	116-121
18449360-1	2007	Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a lipocalin that is well known for its functions as a shuttle for iron and siderophores, which comprises a critical component of innate immunity to exogenous bacterial infections.	Iron	119-123	lipocalin 2	Homo sapiens	44-48
28390898-6	2017	Compared to WT plants, erf72 mutants retained healthy chloroplast structure with significantly higher Fe and Mg content, and decreased chlorophyll degradation gene pheophorbide a oxygenase (PAO) and chlorophyllase (CLH1) expression when grown in iron deficient media.	Iron	102-104	ethylene-responsive element binding protein	Arabidopsis thaliana	23-28
28390898-6	2017	Compared to WT plants, erf72 mutants retained healthy chloroplast structure with significantly higher Fe and Mg content, and decreased chlorophyll degradation gene pheophorbide a oxygenase (PAO) and chlorophyllase (CLH1) expression when grown in iron deficient media.	Iron	246-250	ethylene-responsive element binding protein	Arabidopsis thaliana	23-28
28390898-7	2017	Yeast one-hybrid analysis showed that ERF72 could directly bind to the promoter regions of iron deficiency responses genes IRT1, HA2 and CLH1.	Iron	91-95	ethylene-responsive element binding protein	Arabidopsis thaliana	38-43
17283887-2	2007	At 1 month of age (PM 1), iron reactivity was weak in the gerbil hippocampus.	Iron	26-30	transmembrane protein 11	Homo sapiens	19-23
28390898-7	2017	Yeast one-hybrid analysis showed that ERF72 could directly bind to the promoter regions of iron deficiency responses genes IRT1, HA2 and CLH1.	Iron	91-95	iron-regulated transporter 1	Arabidopsis thaliana	123-127
28390898-7	2017	Yeast one-hybrid analysis showed that ERF72 could directly bind to the promoter regions of iron deficiency responses genes IRT1, HA2 and CLH1.	Iron	91-95	H[+]-ATPase 2	Arabidopsis thaliana	129-132
17241879-1	2007	BACKGROUND &amp; AIMS: Hepcidin is a peptide hormone that is central to the regulation of iron homeostasis.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	23-31
28390898-8	2017	Based on our results, we suggest that ethylene released from plants under iron deficiency stress can activate the expression of ERF72, which responds to iron deficiency in the negative regulation.	Iron	74-78	ethylene-responsive element binding protein	Arabidopsis thaliana	128-133
17241879-2	2007	In response to interleukin 6 (IL-6), hepatocytes produce hepcidin that decreases iron release/transfer from enterocytes and macrophages and causes hypoferremia.	Iron	81-85	hepcidin antimicrobial peptide	Mus musculus	57-65
17241880-0	2007	Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.	Iron	80-84	transferrin receptor 2	Mus musculus	35-57
28767230-0	2017	Mechanistically Driven Development of an Iron Catalyst for Selective Syn-Dihydroxylation of Alkenes with Aqueous Hydrogen Peroxide.	Iron	41-45	synemin	Homo sapiens	69-72
17241880-1	2007	BACKGROUND &amp; AIMS: Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism.	Iron	91-95	transferrin receptor 2	Mus musculus	23-45
17241880-1	2007	BACKGROUND &amp; AIMS: Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism.	Iron	91-95	transferrin receptor 2	Mus musculus	47-51
28880952-1	2017	Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism.	Iron	86-90	hephaestin	Homo sapiens	0-10
17945001-4	2007	In liver, Hfe disruption upregulated genes involved in antioxidant defense, reflecting mechanisms of hepatoprotection activated by iron overload.	Iron	131-135	homeostatic iron regulator	Mus musculus	10-13
28877469-4	2017	TAX1BP1 binds directly to NCOA4 and is required for lysosomal trafficking of ferritin under basal and iron-depleted conditions.	Iron	102-106	Tax1 binding protein 1	Homo sapiens	0-7
17204444-4	2007	Little is known of the function of Neogenin in the adult, however, a novel role in the regulation of iron homeostasis is now emerging.	Iron	101-105	neogenin 1	Homo sapiens	35-43
17766251-4	2007	Here we show that the purified Kae1 protein (Pa-Kae1) from Pyrococcus abyssi is an iron-protein with a novel type of ATP-binding site.	Iron	83-87	tRNA N6-adenosine threonylcarbamoyltransferase	Saccharomyces cerevisiae S288C	31-35
17766251-4	2007	Here we show that the purified Kae1 protein (Pa-Kae1) from Pyrococcus abyssi is an iron-protein with a novel type of ATP-binding site.	Iron	83-87	tRNA N6-adenosine threonylcarbamoyltransferase	Saccharomyces cerevisiae S288C	48-52
28870898-0	2017	Inhibitory Activity of Iron Chelators ATA and DFO on MCF-7 Breast Cancer Cells and Phosphatases PTP1B and SHP2.	Iron	23-27	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	96-101
18605250-1	2007	Methemoglobin (MHb) is the oxidized form of Hemoglobin (Hb) containing iron in its ferric (Fe3+) rather than ferrous (Fe2+) state.	Iron	71-75	hemoglobin subunit gamma 2	Homo sapiens	0-13
18605250-1	2007	Methemoglobin (MHb) is the oxidized form of Hemoglobin (Hb) containing iron in its ferric (Fe3+) rather than ferrous (Fe2+) state.	Iron	71-75	hemoglobin subunit gamma 2	Homo sapiens	15-18
28870898-0	2017	Inhibitory Activity of Iron Chelators ATA and DFO on MCF-7 Breast Cancer Cells and Phosphatases PTP1B and SHP2.	Iron	23-27	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	106-110
28612864-7	2017	MIL-100(Fe) and CPO-27(Ni) are shown to have capacities of 47 mg g-1 and 62 mg g-1 respectively whilst Cu-BTC has a decreased capacity of 37 mg g-1 from 97 mg g-1 upon forming.	Iron	8-10	proline rich protein BstNI subfamily 3	Homo sapiens	65-75
17173478-8	2006	In these lineages, the role of global iron homeostasis was taken by RirA and Irr, two transcriptional regulators that act by sensing the physiological consequence of the metal availability rather than its concentration per se, and thus provide for more flexible regulation.	Iron	38-42	insulin receptor related receptor	Homo sapiens	77-80
16844915-1	2006	Heme oxygenases (HO-1 and HO-2) catalyze the conversion of heme to carbon monoxide (CO), iron, and biliverdin.	Iron	89-93	heme oxygenase 1	Rattus norvegicus	0-30
28612864-9	2017	As expected, Cu-BTC decomposed under these conditions, whilst MIL-100(Fe) and CPO-27(Ni) show slightly decreased ammonia adsorption capacities of 36 mg g-1 and 60 mg g-1 respectively.	Iron	70-72	proline rich protein BstNI subfamily 3	Homo sapiens	152-169
16886906-4	2006	Analysis of the mouse IRP1 promoter sequence revealed two conserved putative binding sites for transcription factor(s) regulated by NO and/or changes in intracellular iron level: Sp1 (promoter-selective transcription factor 1) and MTF1 (metal transcription factor 1), plus GAS (interferon-gamma-activated sequence), a binding site for STAT (signal transducer and activator of transcription) proteins.	Iron	167-171	aconitase 1	Mus musculus	22-26
28777558-0	2017	High-Spin Iron Imido Complexes Competent for C-H Bond Amination.	Iron	10-14	spindlin 1	Homo sapiens	5-9
16996694-3	2006	Another isoform, the duodenal Cyt b561 (Dcytb), was reported to have ferric reductase activity, possibly facilitating intestinal iron uptake.	Iron	129-133	cytochrome b reductase 1	Homo sapiens	40-45
28777558-1	2017	Reduction of previously reported (ArL)FeCl with potassium graphite furnished a low-spin (S = 1/2) iron complex (ArL)Fe which features an intramolecular eta6-arene interaction and can be utilized as an FeI synthon (ArL = 5-mesityl-1,9-(2,4,6-Ph3C6H2)dipyrrin).	Iron	98-102	spindlin 1	Homo sapiens	83-87
28777558-1	2017	Reduction of previously reported (ArL)FeCl with potassium graphite furnished a low-spin (S = 1/2) iron complex (ArL)Fe which features an intramolecular eta6-arene interaction and can be utilized as an FeI synthon (ArL = 5-mesityl-1,9-(2,4,6-Ph3C6H2)dipyrrin).	Iron	38-40	spindlin 1	Homo sapiens	83-87
28655781-0	2017	The hepatocyte-specific HNF4alpha/miR-122 pathway contributes to iron overload-mediated hepatic inflammation.	Iron	65-69	hepatic nuclear factor 4, alpha	Mus musculus	24-33
16882706-1	2006	Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	0-8
16882706-1	2006	Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	0-8
16882706-1	2006	Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	0-8
28655781-7	2017	In addition, both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR-122.	Iron	18-22	hepatic nuclear factor 4, alpha	Mus musculus	178-187
16882706-2	2006	Previous studies indicated that hepcidin is suppressed during anemia, a response that would appropriately increase the absorption of iron and its release from stores.	Iron	133-137	hepcidin antimicrobial peptide	Mus musculus	32-40
16882706-4	2006	The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia, or erythropoietin.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	19-27
28842638-11	2017	Significantly lower Iba-1 and Perls" iron staining in DP1-/- and laropiprant-treated WT groups were observed.	Iron	37-41	transcription factor Dp 1	Mus musculus	54-57
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	microRNA 182	Homo sapiens	135-142
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	ferritin light chain	Homo sapiens	240-243
17116709-1	2006	HFE, a major histocompatibility complex class I-related protein, is implicated in the iron overload disease, hereditary hemochromatosis.	Iron	86-90	homeostatic iron regulator	Mus musculus	0-3
28820960-1	2017	This month: Lysosomal iron linked to cell death in cancer stem cells, non-enzymatic catalyst SynCAc for histone acylation, cytotoxins ivermectin and etoposide bring new anti-fungals out of the crypt, and 2"-deoxy-ADPR as second messenger activating TRPM2.	Iron	22-26	transient receptor potential cation channel subfamily M member 2	Homo sapiens	249-254
17330503-7	2006	IL-1RA concentration was negatively associated with intake of vitamin E and C3 was positively related to intake of Ca and Fe in the subjects with LDL-cholesterol &gt; or = 130 mg/dL.	Iron	122-124	complement C3	Homo sapiens	76-78
28615452-0	2017	Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.	Iron	17-21	N-myc downstream regulated 1	Homo sapiens	54-59
28615452-1	2017	The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer cells.	Iron	4-8	N-myc downstream regulated 1	Homo sapiens	41-74
17151315-3	2006	This article examined the effect of fat-enriched (FE) diet on the pattern of distribution of insulin-, glucagon-, somatostatin-, and pancreatic polypeptide (PP)-positive cells in the pancreatic islets of C57BL/6J mice using immunohistochemical methods.	Iron	50-52	pancreatic polypeptide	Mus musculus	133-155
17151315-3	2006	This article examined the effect of fat-enriched (FE) diet on the pattern of distribution of insulin-, glucagon-, somatostatin-, and pancreatic polypeptide (PP)-positive cells in the pancreatic islets of C57BL/6J mice using immunohistochemical methods.	Iron	50-52	pancreatic polypeptide	Mus musculus	157-159
17151315-9	2006	PP-immunoreactive cells were observed in the peripheral region of the pancreatic islets of both FE- and control diet-fed mice.	Iron	96-98	pancreatic polypeptide	Mus musculus	0-2
17151315-11	2006	In conclusion, the number of PP is significantly reduced in FE diet-fed mice and may play a role in the pathogenesis of diet-induced metabolic syndrome in C57BL/6J mice.	Iron	60-62	pancreatic polypeptide	Mus musculus	29-31
28615452-1	2017	The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer cells.	Iron	4-8	N-myc downstream regulated 1	Homo sapiens	76-81
28779110-6	2017	Mutant experiments show that conserved cysteine residues of Fe-S clusters of CDKAL1 are essential for its anti-adipogenic action.	Iron	60-64	CDK5 regulatory subunit associated protein 1-like 1	Mus musculus	77-83
17074835-7	2006	The absence of both Grx3 and Grx4 induced a clear enrichment of G1 cells in asynchronous cultures, a slow growth phenotype, the accumulation of intracellular iron and a constitutive activation of the genes regulated by Aft1.	Iron	158-162	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	20-24
28639108-4	2017	In this work, we aimed to test the effects of FBP in HSC cell line, GRX, exposed to an excess of iron (Fe).	Iron	97-101	fructose-bisphosphatase 1	Homo sapiens	46-49
17044718-6	2006	In both spin states, the iron is intermediate spin (S(Fe) = 1) ferrous.	Iron	25-29	spindlin 1	Homo sapiens	8-12
17044718-6	2006	In both spin states, the iron is intermediate spin (S(Fe) = 1) ferrous.	Iron	25-29	spindlin 1	Homo sapiens	46-50
17044718-7	2006	Experimentally, the compound has a spin singlet ground state (S = 0) due to antiferromagnetic coupling of iron and the ligand triplet state.	Iron	106-110	spindlin 1	Homo sapiens	35-39
28639108-5	2017	The Fe-treatment increased cell proliferation and FBP reversed this effect, which was not due to increased necrosis, apoptosis or changes in cell cycle.	Iron	4-6	fructose-bisphosphatase 1	Homo sapiens	50-53
16926153-1	2006	Deletion of the yeast gene PKR1 (YMR123W) results in an inability to grow on iron-limited medium.	Iron	77-81	Pkr1p	Saccharomyces cerevisiae S288C	27-31
28639108-8	2017	Both effects were reversed by FBP which also decreased TGF-beta1 levels in comparison to both control and Fe groups.	Iron	106-108	fructose-bisphosphatase 1	Homo sapiens	30-33
28639108-12	2017	FBP also chelates iron showing potential to improve Cell redox state.	Iron	18-22	fructose-bisphosphatase 1	Homo sapiens	0-3
28829493-0	2017	Effects of IL-10 on iron metabolism in LPS-induced inflammatory mice via modulating hepcidin expression.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	84-92
16792525-1	2006	Protoporhyrin IX ferrochelatase catalyses the terminal step of the haem-biosynthetic pathway by inserting ferrous iron into protoporphyrin IX.	Iron	106-118	ferrochelatase	Mus musculus	17-31
28829493-3	2017	Hepcidin can regulate iron metabolic homeostasis, further mediating renal anemia.	Iron	22-26	hepcidin antimicrobial peptide	Mus musculus	0-8
28450059-9	2017	We next demonstrated that reducing ferroportin expression in vitro by ferroportin-specific siRNAs or hepcidin significantly increased the intracellular iron content.	Iron	152-156	hepcidin antimicrobial peptide	Mus musculus	101-109
17040095-5	2006	The electrode potential of the iron-CP20 system decreases as a function of increasing pH, with a minimum near pH 10.5.	Iron	31-35	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	36-40
17040095-6	2006	We estimate an electrode potential for the ascorbyl radical/ascorbate couple under physiological conditions of +105 mV, which is higher than the electrode potential of the iron(III) complex of CP20 at all concentrations of iron.	Iron	172-176	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	193-197
17014552-4	2006	Reticulocyte haemoglobin content (CHr) is one of several iron indices used to determine iron deficiency in dialysis patients.	Iron	57-61	chromate resistance; sulfate transport	Homo sapiens	34-37
17014552-5	2006	The aim of this study is to evaluate the role of CRP and CHr in iron administration and anaemia management in dialysis patients.	Iron	64-68	chromate resistance; sulfate transport	Homo sapiens	57-60
16871511-5	2006	As reported previously, the catalytic behavior of cis-alpha and cis-beta isomers of [Fe(bpmcn)(OTf)2] with respect to olefin oxidation depends dramatically on the geometry adopted by the iron complex.	Iron	187-191	POU class 2 homeobox 2	Homo sapiens	95-100
16790430-1	2006	Iron acquisition in Arabidopsis depends mainly on AtIRT1, a Fe2+ transporter in the plasma membrane of root cells.	Iron	0-4	iron-regulated transporter 1	Arabidopsis thaliana	50-56
16790430-2	2006	However, substrate specificity of AtIRT1 is low, leading to an excess accumulation of other transition metals in iron-deficient plants.	Iron	113-117	iron-regulated transporter 1	Arabidopsis thaliana	34-40
16790430-3	2006	In the present study we describe AtIREG2 as a nickel transporter at the vacuolar membrane that counterbalances the low substrate specificity of AtIRT1 and possibly other iron transport systems in iron-deficient root cells.	Iron	170-174	iron-regulated transporter 1	Arabidopsis thaliana	144-150
16790430-3	2006	In the present study we describe AtIREG2 as a nickel transporter at the vacuolar membrane that counterbalances the low substrate specificity of AtIRT1 and possibly other iron transport systems in iron-deficient root cells.	Iron	196-200	iron-regulated transporter 1	Arabidopsis thaliana	144-150
16933319-0	2006	Distribution of the iron-regulating protein hepcidin in the murine central nervous system.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	44-52
16933319-3	2006	It has been discovered recently that hepcidin plays an essential role in iron metabolism outside the CNS.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	37-45
16933319-8	2006	Because hepcidin action in organs outside the CNS is linked to iron homeostasis, we speculate that it is also involved in such processes in the CNS, putatively together with other iron regulating proteins.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	8-16
16933319-8	2006	Because hepcidin action in organs outside the CNS is linked to iron homeostasis, we speculate that it is also involved in such processes in the CNS, putatively together with other iron regulating proteins.	Iron	180-184	hepcidin antimicrobial peptide	Mus musculus	8-16
16940998-0	2006	Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse.	Iron	0-4	iron responsive element binding protein 2	Mus musculus	40-65
16574947-6	2006	Confirming our prior results, Hepc1(-/-) mice developed early and severe multivisceral iron overload, with sparing of the spleen macrophages, and demonstrated increased serum iron and ferritin levels as compared with their controls.	Iron	175-179	hepcidin antimicrobial peptide	Mus musculus	30-35
16609065-4	2006	Now, through homology, expression, and functional studies, we characterize all 4 members of this protein family and demonstrate that 3 of them, Steap2, Steap3, and Steap4, are not only ferrireductases but also cupric reductases that stimulate cellular uptake of both iron and copper in vitro.	Iron	267-271	STEAP4 metalloreductase	Homo sapiens	164-170
16386362-6	2006	Nitroso compounds (MNX, DNX, and TNX), nitrate, nitrite and nitrous oxide were identified as the main by-products for the RDX reduction by ZVI.	Iron	139-142	tenascin XA (pseudogene)	Homo sapiens	33-36
16510471-2	2006	Because cellular iron uptake requires membrane ferrireductase activity that in the gut can be provided by duodenal cytochrome b (Dcytb), we sought Dcytb in the lung to test the hypothesis that it contributes to epithelial iron regulation by reducing Fe(3+) for cellular iron transport.	Iron	17-21	cytochrome b reductase 1	Homo sapiens	106-127
16510471-3	2006	Dcytb expression was found in respiratory epithelium in vitro and in vivo and was responsive to iron concentration.	Iron	96-100	cytochrome b reductase 1	Homo sapiens	0-5
16510471-4	2006	Iron transport was measured in human bronchial epithelial (HBE) cells using inductively coupled plasma atomic emission spectroscopy and was demonstrated to be partially inhibited in the presence of Dcytb-blocking antibody, suggesting that Dcytb reduces Fe(3+) for cellular iron transport.	Iron	0-4	cytochrome b reductase 1	Homo sapiens	198-203
16510471-4	2006	Iron transport was measured in human bronchial epithelial (HBE) cells using inductively coupled plasma atomic emission spectroscopy and was demonstrated to be partially inhibited in the presence of Dcytb-blocking antibody, suggesting that Dcytb reduces Fe(3+) for cellular iron transport.	Iron	0-4	cytochrome b reductase 1	Homo sapiens	239-244
16510471-4	2006	Iron transport was measured in human bronchial epithelial (HBE) cells using inductively coupled plasma atomic emission spectroscopy and was demonstrated to be partially inhibited in the presence of Dcytb-blocking antibody, suggesting that Dcytb reduces Fe(3+) for cellular iron transport.	Iron	253-255	cytochrome b reductase 1	Homo sapiens	198-203
16510471-4	2006	Iron transport was measured in human bronchial epithelial (HBE) cells using inductively coupled plasma atomic emission spectroscopy and was demonstrated to be partially inhibited in the presence of Dcytb-blocking antibody, suggesting that Dcytb reduces Fe(3+) for cellular iron transport.	Iron	253-255	cytochrome b reductase 1	Homo sapiens	239-244
16510471-4	2006	Iron transport was measured in human bronchial epithelial (HBE) cells using inductively coupled plasma atomic emission spectroscopy and was demonstrated to be partially inhibited in the presence of Dcytb-blocking antibody, suggesting that Dcytb reduces Fe(3+) for cellular iron transport.	Iron	273-277	cytochrome b reductase 1	Homo sapiens	198-203
16510471-4	2006	Iron transport was measured in human bronchial epithelial (HBE) cells using inductively coupled plasma atomic emission spectroscopy and was demonstrated to be partially inhibited in the presence of Dcytb-blocking antibody, suggesting that Dcytb reduces Fe(3+) for cellular iron transport.	Iron	273-277	cytochrome b reductase 1	Homo sapiens	239-244
16510471-8	2006	The presence of Dcytb in airway epithelial cells and its regulation by iron therefore may contribute to pulmonary cytoprotection.	Iron	71-75	cytochrome b reductase 1	Homo sapiens	16-21
16565419-0	2006	Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.	Iron	70-74	homeostatic iron regulator	Mus musculus	26-29
16565419-0	2006	Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	51-59
16565419-1	2006	Hepcidin is a negative regulator of iron absorption produced mainly by the liver in response to changes in iron stores and inflammation, and its levels have been shown to regulate the intestinal basolateral iron transporter ferroportin1 (Fp1).	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	0-8
16565419-1	2006	Hepcidin is a negative regulator of iron absorption produced mainly by the liver in response to changes in iron stores and inflammation, and its levels have been shown to regulate the intestinal basolateral iron transporter ferroportin1 (Fp1).	Iron	107-111	hepcidin antimicrobial peptide	Mus musculus	0-8
16552559-2	2006	This is accompanied by an increased expression of divalent metal transporter-1 (DMT1) in the lesioned hippocampus, suggesting that the transporter may be partially responsible for the iron accumulation.	Iron	184-188	RoBo-1	Rattus norvegicus	50-78
16552559-2	2006	This is accompanied by an increased expression of divalent metal transporter-1 (DMT1) in the lesioned hippocampus, suggesting that the transporter may be partially responsible for the iron accumulation.	Iron	184-188	RoBo-1	Rattus norvegicus	80-84
16863914-12	2006	CONCLUSIONS: Myelosuppressive effects of iron-binding proteins HF and LF and chemokines CCL3, CXCL5, and CXCL8 on mouse bone marrow HPC require expression of MHC class II antigens, and CIITA is involved in this responsiveness through its regulation of expression of MHC class II antigens.	Iron	41-45	ferritin heavy polypeptide 1	Mus musculus	63-65
16875497-9	2006	The large hepatic mononuclear cell infiltrates seen in Hfe-/- stained for ferritin, may point to the iron sequestration capacity of lymphocytes and contribute to the clarification of the differences found in the progression of hepatic iron overload and steatosis in older animals from the two strains.	Iron	101-105	homeostatic iron regulator	Mus musculus	55-58
16875497-9	2006	The large hepatic mononuclear cell infiltrates seen in Hfe-/- stained for ferritin, may point to the iron sequestration capacity of lymphocytes and contribute to the clarification of the differences found in the progression of hepatic iron overload and steatosis in older animals from the two strains.	Iron	235-239	homeostatic iron regulator	Mus musculus	55-58
16766055-6	2006	A combination of classical genetics, differential expression and genomic analysis has led to the identification of homologues of components known to operate in fungi and animals (e.g., Fox1, Ftr1, Fre1, Fer1, Ctr1/2) as well as novel molecules involved in copper and iron nutrition (Crr1, Fea1/2).	Iron	267-271	uncharacterized protein	Chlamydomonas reinhardtii	191-195
16551614-0	2006	Characterization of the interaction between the J-protein Jac1p and the scaffold for Fe-S cluster biogenesis, Isu1p.	Iron	85-89	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	58-63
16551614-1	2006	Jac1p is a conserved, specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria of the yeast Saccharomyces cerevisiae.	Iron	73-75	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	0-5
16686545-2	2006	The extrapolated affinity constants beta(1), beta(2), and beta(3)( )()for iron(III) in aqueous solution were 9.95, 18.69, and 26.02, respectively, with a corresponding pFe(3+) value of 14.64.	Iron	74-78	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	36-42
16651563-1	2006	Nramp (Slc11a1) genes in mammals are associated with the transport of iron and other divalent cations; Nramp1 in macrophages involved in the innate immune response against intracellular pathogens, and Nramp2 with duodenal iron uptake and the transferrin-transferrin-receptor pathway of iron assimilation.	Iron	70-74	Malvolio	Drosophila melanogaster	0-5
16651563-1	2006	Nramp (Slc11a1) genes in mammals are associated with the transport of iron and other divalent cations; Nramp1 in macrophages involved in the innate immune response against intracellular pathogens, and Nramp2 with duodenal iron uptake and the transferrin-transferrin-receptor pathway of iron assimilation.	Iron	222-226	Malvolio	Drosophila melanogaster	0-5
16651563-1	2006	Nramp (Slc11a1) genes in mammals are associated with the transport of iron and other divalent cations; Nramp1 in macrophages involved in the innate immune response against intracellular pathogens, and Nramp2 with duodenal iron uptake and the transferrin-transferrin-receptor pathway of iron assimilation.	Iron	222-226	Malvolio	Drosophila melanogaster	0-5
16598857-1	2006	Heme oxygenase-1 (HO-1), the rate-limiting enzyme in catalyzing heme degradation into biliverdin, free iron, and carbon monoxide (CO), serves as a protective enzyme against oxidative and nitrosative stresses.	Iron	103-107	heme oxygenase 1	Rattus norvegicus	0-16
16598857-1	2006	Heme oxygenase-1 (HO-1), the rate-limiting enzyme in catalyzing heme degradation into biliverdin, free iron, and carbon monoxide (CO), serves as a protective enzyme against oxidative and nitrosative stresses.	Iron	103-107	heme oxygenase 1	Rattus norvegicus	18-22
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	85-89	transferrin	Mus musculus	6-17
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	91-93	transferrin	Mus musculus	6-17
16291590-1	2006	Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation.	Iron	174-176	transferrin	Mus musculus	6-17
16614385-1	2006	Ferrochelatase (protohaem ferrolyase, EC 4.99.1.1), the terminal enzyme of the haem biosynthetic pathway, catalyses the insertion of ferrous iron into protoporphyrin IX to form protohaem.	Iron	133-145	ferrochelatase	Homo sapiens	0-14
16469386-0	2006	Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.	Iron	71-75	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	76-80
16469386-3	2006	Recently, it was discovered that some of the alkylation DNA base damage can be directly removed by a family of proteins called the AlkB proteins that utilize a mononuclear non-heme iron(II) and alpha-ketoglutarate as cofactor and cosubstrate.	Iron	181-185	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	131-135
16489134-13	2006	We propose that AtFRO6 expression is light regulated in a tissue- or cell differentiation-specific manner to facilitate the acquisition of iron in response to distinctive developmental cues.	Iron	139-143	ferric reduction oxidase 6	Arabidopsis thaliana	16-22
16455656-12	2006	We conclude that CpNifS and CpSufE together form a cysteine desulfurase required for iron-sulfur cluster formation in chloroplasts.	Iron	85-89	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	17-23
16467350-7	2006	In this situation, control of iron regulatory protein 1, a key cytosolic modulator of iron metabolism, which is responsive to the availability of cytosolic Fe-S clusters, was impaired and contributed to the dysregulation of hepatocyte iron metabolism.	Iron	156-160	aconitase 1	Mus musculus	30-55
16467350-7	2006	In this situation, control of iron regulatory protein 1, a key cytosolic modulator of iron metabolism, which is responsive to the availability of cytosolic Fe-S clusters, was impaired and contributed to the dysregulation of hepatocyte iron metabolism.	Iron	86-90	aconitase 1	Mus musculus	30-55
16540399-8	2006	The *NO/cGMP/cAMP signaling pathway mitigates transferrin-iron-mediated oxidative stress and apoptosis through induction of immunoproteasomes.	Iron	58-62	transferrin	Mus musculus	46-57
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	172-176	glutathione peroxidase 1	Homo sapiens	118-142
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	172-176	glutathione peroxidase 1	Homo sapiens	144-148
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	196-200	glutathione peroxidase 1	Homo sapiens	118-142
16510607-1	2006	Manganese superoxide dismutase (MnSOD) converts the superoxide anion into H(2)O(2), which, unless it is detoxified by glutathione peroxidase 1 (GPx1), can increase hepatic iron and can react with iron to form genotoxic compounds.	Iron	196-200	glutathione peroxidase 1	Homo sapiens	144-148
28585096-0	2017	Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.	Iron	94-98	hepcidin antimicrobial peptide	Mus musculus	107-115
16448835-1	2006	In an attempt to identify a sensitive and improved marker of mammalian copper status during neonatal development experiments compared two plasma cuproenzymes, peptidylglycine alpha-amidating monooxygenase (PAM ), an enzyme involved in peptide posttranslational activation, to ceruloplasmin (Cp), a ferroxidase involved in iron mobilization.	Iron	322-326	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	206-209
28585096-1	2017	Expression of the hepatic peptide hormone hepcidin responds to iron levels via BMP/SMAD signaling, to inflammatory cues via JAK/STAT signaling, to the nutrient-sensing mTOR pathway, as well as to proliferative signals and gluconeogenesis.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	42-50
28476637-5	2017	The interplay between iron and Nramp1 exhibited parallel effects on the clearance of alpha-synuclein and the activity of lysosomal cathepsin D in vitro and in vivo.	Iron	22-26	cathepsin D	Mus musculus	131-142
16424878-0	2006	Stratum-specific expression of human transferrin receptor increases iron in mouse epidermis.	Iron	68-72	transferrin	Mus musculus	37-48
28777635-1	2017	Spin-polarized scanning tunneling microscopy investigations reveal a significant increase of the magnetic period of spin spirals in three-atomic-layer-thick Fe films on Ir(111), from about 4 nm at 8 K to about 65 nm at room temperature.	Iron	157-159	spindlin 1	Homo sapiens	0-4
16424878-3	2006	To test the importance of the transferrin receptor in regulating iron content in epidermis, we created transgenic mice that have stratum-specific expression of the human transferrin receptor.	Iron	65-69	transferrin	Mus musculus	30-41
16424878-7	2006	Iron was increased up to 2-fold in hair of keratin 14-human transferrin receptor (hTfR) transgenics and 30% in Inv-hTfR transgenics.	Iron	0-4	transferrin	Mus musculus	60-71
28777635-1	2017	Spin-polarized scanning tunneling microscopy investigations reveal a significant increase of the magnetic period of spin spirals in three-atomic-layer-thick Fe films on Ir(111), from about 4 nm at 8 K to about 65 nm at room temperature.	Iron	157-159	spindlin 1	Homo sapiens	116-120
16437160-1	2006	In the budding yeast Saccharomyces cerevisiae, transcription of genes encoding for the high-affinity iron (FET3, FTR1) and copper (CTR1) transporters does not occur in the absence of heme.	Iron	101-105	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	113-117
28777635-2	2017	We attribute this considerable influence of temperature on the magnetic length scale of noncollinear spin states to different exchange interaction coefficients in the different Fe layers.	Iron	177-179	spindlin 1	Homo sapiens	101-105
16437160-7	2006	We hypothesize that transcription of the siderophore transporter ARN1 permits yeast to accumulate iron in the absence of oxygen and to deny iron to competing organisms.	Iron	98-102	siderophore transporter	Saccharomyces cerevisiae S288C	65-69
16437160-7	2006	We hypothesize that transcription of the siderophore transporter ARN1 permits yeast to accumulate iron in the absence of oxygen and to deny iron to competing organisms.	Iron	140-144	siderophore transporter	Saccharomyces cerevisiae S288C	65-69
28515324-4	2017	Recent studies show that RNR cofactor biosynthesis shares the same source of iron, in the form of [2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for maturation of [4Fe-4S] clusters in cytosolic and nuclear proteins.	Iron	77-81	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	144-150
16328372-5	2006	In contrast, deletion of the AFT1 and AFT2 transcription factor genes blocked the HU activation of a subset of the Aft regulon and the aft1Delta aft2Delta double mutant was hypersensitive to HU in an iron-suppressible manner.	Iron	200-204	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	29-33
16629180-2	2006	A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding the transcription factor USF2 failed to produce Hepc mRNA and developed spontaneous visceral iron overload.	Iron	26-30	hepcidin antimicrobial peptide	Mus musculus	18-22
16629180-2	2006	A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding the transcription factor USF2 failed to produce Hepc mRNA and developed spontaneous visceral iron overload.	Iron	217-221	hepcidin antimicrobial peptide	Mus musculus	18-22
28515324-10	2017	We conclude that RNR cofactor biogenesis requires the ISC machinery to mature the Grx3/4 and Dre2 Fe-S proteins, which then function in iron and electron delivery to RNR, respectively.	Iron	136-140	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	82-88
28421266-6	2017	The results showed that iron overload could reduce the percentage of CD3+ T cells and the ratio of Th1/Th2 and Tc1/Tc2 but increase the percentage of regulatory T (Treg) cells and the ratio of CD4/CD8.	Iron	24-28	transcobalamin 2	Mus musculus	115-118
16271796-0	2006	Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse.	Iron	8-12	homeostatic iron regulator	Mus musculus	78-81
16271796-0	2006	Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse.	Iron	58-62	homeostatic iron regulator	Mus musculus	78-81
16271796-3	2006	METHODS: Iron release by hepatocytes from Hfe knockout, non-iron-loaded and iron-loaded wild-type mice was measured after incubation with nontransferrin-bound iron as iron-citrate.	Iron	9-13	homeostatic iron regulator	Mus musculus	42-45
16271796-5	2006	When expressed as a percentage of total iron uptake, iron release was decreased in Hfe knockout hepatocytes (4.6+/-0.7 versus 13.7+/-1.2%, P&lt;0.0001) and increased in iron-loaded wild-type hepatocytes (29.5+/-0.5 versus 13.5+/-0.7%; P&lt;0.0001) compared with wild-type hepatocytes.	Iron	40-44	homeostatic iron regulator	Mus musculus	83-86
16271796-5	2006	When expressed as a percentage of total iron uptake, iron release was decreased in Hfe knockout hepatocytes (4.6+/-0.7 versus 13.7+/-1.2%, P&lt;0.0001) and increased in iron-loaded wild-type hepatocytes (29.5+/-0.5 versus 13.5+/-0.7%; P&lt;0.0001) compared with wild-type hepatocytes.	Iron	53-57	homeostatic iron regulator	Mus musculus	83-86
16271796-5	2006	When expressed as a percentage of total iron uptake, iron release was decreased in Hfe knockout hepatocytes (4.6+/-0.7 versus 13.7+/-1.2%, P&lt;0.0001) and increased in iron-loaded wild-type hepatocytes (29.5+/-0.5 versus 13.5+/-0.7%; P&lt;0.0001) compared with wild-type hepatocytes.	Iron	53-57	homeostatic iron regulator	Mus musculus	83-86
28421266-6	2017	The results showed that iron overload could reduce the percentage of CD3+ T cells and the ratio of Th1/Th2 and Tc1/Tc2 but increase the percentage of regulatory T (Treg) cells and the ratio of CD4/CD8.	Iron	24-28	CD4 antigen	Mus musculus	193-196
16271796-6	2006	In contrast, in vitro iron-loading increased iron release and ferroportin expression by both Hfe knockout and wild-type hepatocytes.	Iron	22-26	homeostatic iron regulator	Mus musculus	93-96
16271796-7	2006	CONCLUSIONS: Hfe knockout hepatocytes accumulate iron as a result of limited iron export and enhanced iron uptake.	Iron	49-53	homeostatic iron regulator	Mus musculus	13-16
28385785-1	2017	Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	98-106
16271796-7	2006	CONCLUSIONS: Hfe knockout hepatocytes accumulate iron as a result of limited iron export and enhanced iron uptake.	Iron	77-81	homeostatic iron regulator	Mus musculus	13-16
16271796-7	2006	CONCLUSIONS: Hfe knockout hepatocytes accumulate iron as a result of limited iron export and enhanced iron uptake.	Iron	77-81	homeostatic iron regulator	Mus musculus	13-16
28385785-1	2017	Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis.	Iron	141-145	hepcidin antimicrobial peptide	Mus musculus	98-106
17017567-3	2006	Iron chelators (desferal, Vk-28 and clioquinol) but not copper chelators have been shown to be neuroprotective in the 6-hydroxydoapmine and MPTP models of Parkinson"s disease (PD), as are monoamine oxidase B inhibitors such as selegiline and rasagiline.	Iron	0-4	monoamine oxidase B	Homo sapiens	188-207
28702011-5	2017	HIP HOP profiling in Saccharomyces cerevisiae using a panel of signature strains that are characteristic for common modes of action identified hypersensitivity in yeast lacking the iron-dependent transcription factor Aft1 suggesting restricted iron uptake as a mode of action.	Iron	181-185	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	217-221
16443171-14	2006	Both are compatible with the more marked expression of divalent metal transporter 1 (DMT-1) and IREG-1 at the brushborder and basolateral membrane of iron-deficient enterocytes.	Iron	150-154	RoBo-1	Rattus norvegicus	55-83
16443171-14	2006	Both are compatible with the more marked expression of divalent metal transporter 1 (DMT-1) and IREG-1 at the brushborder and basolateral membrane of iron-deficient enterocytes.	Iron	150-154	RoBo-1	Rattus norvegicus	85-90
28702011-5	2017	HIP HOP profiling in Saccharomyces cerevisiae using a panel of signature strains that are characteristic for common modes of action identified hypersensitivity in yeast lacking the iron-dependent transcription factor Aft1 suggesting restricted iron uptake as a mode of action.	Iron	244-248	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	217-221
28498652-6	2017	This conformational change shortens the Fe-N bonds by 3%, which changes the Fe spin state from S = 2 to S = 1.	Iron	40-44	spindlin 1	Homo sapiens	79-83
16084103-0	2006	Highly anisotropic distribution of iron nanoparticles within MCM-41 Mesoporous Silica.	Iron	35-39	methylmalonyl-CoA mutase	Homo sapiens	61-64
16084103-1	2006	Electron microscopy techniques are used to visualize the spatial distribution of iron nanoparticles inside a mesoporous MCM-41 molecular sieve.	Iron	81-85	methylmalonyl-CoA mutase	Homo sapiens	120-123
28498652-6	2017	This conformational change shortens the Fe-N bonds by 3%, which changes the Fe spin state from S = 2 to S = 1.	Iron	40-42	spindlin 1	Homo sapiens	79-83
16317519-5	2006	Western blot was performed to detect the expression of iron transport proteins: divalent metal transporter1 (DMT1) and ferroportin 1 (FPN1) in duodenal epithelium.	Iron	55-59	RoBo-1	Rattus norvegicus	80-107
28721153-11	2017	Our data are paving the way for further studies on the role of FGF-23 in iron metabolism, especially in early stages of CKD.	Iron	73-77	fibroblast growth factor 23	Homo sapiens	63-69
16317519-5	2006	Western blot was performed to detect the expression of iron transport proteins: divalent metal transporter1 (DMT1) and ferroportin 1 (FPN1) in duodenal epithelium.	Iron	55-59	RoBo-1	Rattus norvegicus	109-113
16317519-7	2006	The results showed: (1) the body iron status in MG was kept at a high level compared to that of CG and SG, (2) Western blot showed DMT1 with iron responsive element (IRE) and FPN1 in duodenal epithelium which were higher in MG than that of CG and (3) the expression of hepatic hepcidin mRNA was down regulated in MG (p &lt; 0.05).	Iron	33-37	RoBo-1	Rattus norvegicus	131-135
16317519-7	2006	The results showed: (1) the body iron status in MG was kept at a high level compared to that of CG and SG, (2) Western blot showed DMT1 with iron responsive element (IRE) and FPN1 in duodenal epithelium which were higher in MG than that of CG and (3) the expression of hepatic hepcidin mRNA was down regulated in MG (p &lt; 0.05).	Iron	141-145	RoBo-1	Rattus norvegicus	131-135
16317519-8	2006	The data suggested that moderate exercise improved iron status and that was likely regulated by increased DMT1 with IRE and FPN1 expression.	Iron	51-55	RoBo-1	Rattus norvegicus	106-110
28499927-0	2017	Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	18-26
16497104-1	2006	Hepcidin, a key regulator of iron metabolism, decreases intestinal absorption of iron and its release from macrophages.	Iron	81-85	hepcidin antimicrobial peptide	Mus musculus	0-8
16497104-2	2006	Iron, anemia, hypoxia, and inflammation were reported to influence hepcidin expression.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	67-75
27494818-6	2017	RESULTS In the Fe-injection group, minocycline suppressed WMI labeled by beta-amyloid precursor protein (beta-APP) and degraded myelin basic protein (dMBP)/MBP ratio.	Iron	15-17	amyloid beta precursor protein	Rattus norvegicus	73-103
16497104-11	2006	We propose that hepcidin is exclusively sensitive to iron utilization for erythropoiesis and hepatocyte iron balance, and these changes are not sensed by other genes involved in the control of iron metabolism in the liver.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	16-24
16497104-11	2006	We propose that hepcidin is exclusively sensitive to iron utilization for erythropoiesis and hepatocyte iron balance, and these changes are not sensed by other genes involved in the control of iron metabolism in the liver.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	16-24
16497104-11	2006	We propose that hepcidin is exclusively sensitive to iron utilization for erythropoiesis and hepatocyte iron balance, and these changes are not sensed by other genes involved in the control of iron metabolism in the liver.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	16-24
27494818-6	2017	RESULTS In the Fe-injection group, minocycline suppressed WMI labeled by beta-amyloid precursor protein (beta-APP) and degraded myelin basic protein (dMBP)/MBP ratio.	Iron	15-17	amyloid beta precursor protein	Rattus norvegicus	105-113
27494818-6	2017	RESULTS In the Fe-injection group, minocycline suppressed WMI labeled by beta-amyloid precursor protein (beta-APP) and degraded myelin basic protein (dMBP)/MBP ratio.	Iron	15-17	myelin basic protein	Rattus norvegicus	128-148
17165447-0	2006	Zero-valent iron treatment of RDX-containing and perchlorate-containing wastewaters from an ammunition-manufacturing plant at elevated temperatures.	Iron	12-16	radixin	Homo sapiens	30-33
27494818-6	2017	RESULTS In the Fe-injection group, minocycline suppressed WMI labeled by beta-amyloid precursor protein (beta-APP) and degraded myelin basic protein (dMBP)/MBP ratio.	Iron	15-17	myelin basic protein	Rattus norvegicus	151-154
17165447-1	2006	The use of zero-valent iron for treating wastewaters containing RDX and perchlorate from an army ammunition plant (AAP) in the USA at elevated temperatures and moderately elevated temperature with chemical addition was evaluated through batch and column experiments.	Iron	23-27	radixin	Homo sapiens	64-67
28521769-0	2017	Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	55-63
17165447-2	2006	RDX in the wastewater was completely removed in an iron column after 6.4 minutes.	Iron	51-55	radixin	Homo sapiens	0-3
17165447-6	2006	Based on the evaluation results, we propose two innovative processes for treating RDX-containing and perchlorate-containing wastewaters: a temperature and pressure-controlled batch iron reactor and subsequent oxidation by existing industrial wastewater treatment plant; and reduction by consecutive iron columns with heating and acid addition capabilities and subsequent oxidation.	Iron	181-185	radixin	Homo sapiens	82-85
17165447-6	2006	Based on the evaluation results, we propose two innovative processes for treating RDX-containing and perchlorate-containing wastewaters: a temperature and pressure-controlled batch iron reactor and subsequent oxidation by existing industrial wastewater treatment plant; and reduction by consecutive iron columns with heating and acid addition capabilities and subsequent oxidation.	Iron	299-303	radixin	Homo sapiens	82-85
28521769-2	2017	The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	12-20
16351643-2	2005	Hepcidin, a liver-produced peptide, has recently been identified as a negative regulator of iron absorption in various conditions associated with altered iron metabolism (e.g. inflammation, anaemia, hypoxia).	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	0-8
28521769-2	2017	The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	12-20
16351643-2	2005	Hepcidin, a liver-produced peptide, has recently been identified as a negative regulator of iron absorption in various conditions associated with altered iron metabolism (e.g. inflammation, anaemia, hypoxia).	Iron	154-158	hepcidin antimicrobial peptide	Mus musculus	0-8
16330325-4	2005	Transcript levels of genes involved in intestinal iron absorption, including Dcytb, DMT1, and ferroportin, are significantly elevated in the absence of hepcidin.	Iron	50-54	cytochrome b reductase 1	Homo sapiens	77-82
28521769-4	2017	Here we test the hypothesis that hepcidin alone is able to regulate iron distribution in different dietary regimes in the mouse using a computational model of iron distribution calibrated with radioiron tracer data.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	33-41
28511672-12	2017	The mRNA levels of iron-responsive genes, such as CrNRAMP2, CrATX1, CrFTR1, and CrFEA1, were also remarkably reduced.	Iron	19-23	uncharacterized protein	Chlamydomonas reinhardtii	68-74
16283625-1	2005	Central aspects of cellular iron metabolism are controlled by IRP1 and IRP2, which are ubiquitously expressed in mouse organs and cells.	Iron	28-32	aconitase 1	Mus musculus	62-66
16283625-1	2005	Central aspects of cellular iron metabolism are controlled by IRP1 and IRP2, which are ubiquitously expressed in mouse organs and cells.	Iron	28-32	iron responsive element binding protein 2	Mus musculus	71-75
16283625-7	2005	For both Irp genes, Cre-assisted deletion of exon 3 generates complete null alleles that, in the case of IRP2, are associated with altered body iron distribution and compromised hematopoiesis.	Iron	144-148	iron responsive element binding protein 2	Mus musculus	105-109
28212822-8	2017	The optimum values of the operational parameters during this study are found to be 80mgL-1 for the divalent iron, 30mgL-1 for ascorbic acid, 30mmol for hydrogen peroxide, 25mgL-1 for pro-oxidants and an exposure time equal to 5min.	Iron	108-112	LLGL scribble cell polarity complex component 1	Homo sapiens	85-90
16289749-2	2005	While iron transport by transferrin receptor-mediated endocytosis is well understood, it is not completely clear how iron is transported from the endosome to the mitochondria where heme is synthesized.	Iron	6-10	transferrin	Mus musculus	24-35
16354190-4	2005	In Hfe(-/-) mice, iron content in the epidermis and dermis was unexpectedly the same as in Hfe(+/+) mice, and there were no histological abnormalities detected after 30 wk.	Iron	18-22	homeostatic iron regulator	Mus musculus	3-6
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	148-152	RoBo-1	Rattus norvegicus	0-28
28507548-1	2017	Retention of iron in tissue macrophages via upregulation of hepcidin (HAMP) and downregulation of the iron exporter ferroportin (FPN) is thought to participate in the establishment of anemia of inflammation after infection.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	70-74
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	148-152	RoBo-1	Rattus norvegicus	30-34
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	157-159	RoBo-1	Rattus norvegicus	0-28
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	157-159	RoBo-1	Rattus norvegicus	30-34
16137791-3	2005	We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR.	Iron	40-42	RoBo-1	Rattus norvegicus	128-132
28024081-2	2017	The resulting frataxin protein deficiency leads to a Fe-S cluster biosynthesis dysfunction in the mitochondria and to oxidative stress and cell death.	Iron	53-57	frataxin	Mus musculus	14-22
16277531-3	2005	Consideration of 57Fe hyperfine coupling in S(EPR1) and lo-CO leads to a picture in which CO bridges two Fe of lo-CO, while the C2H4 of S(EPR1) binds to one of these.	Iron	19-21	baculoviral IAP repeat containing 5	Homo sapiens	138-142
27429427-16	2017	The optimal prognostic value for inflammation-adjusted CHr to predict iron deficiency was 34 pg (area under the receiver operating characteristic of 0.70), with 88% sensitivity and 30% specificity.	Iron	70-74	chromate resistance; sulfate transport	Homo sapiens	55-58
16274220-1	2005	Human hephaestin (Hp) is a transmembrane protein that has been implicated in duodenal iron export.	Iron	86-90	hephaestin	Homo sapiens	6-16
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	143-147	hepcidin antimicrobial peptide	Mus musculus	98-102
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	143-147	homeostatic iron regulator	Mus musculus	160-163
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	143-147	transferrin receptor 2	Mus musculus	165-169
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	143-147	hemojuvelin BMP co-receptor	Mus musculus	174-177
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	227-231	hepcidin antimicrobial peptide	Mus musculus	98-102
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	227-231	homeostatic iron regulator	Mus musculus	160-163
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	227-231	hemojuvelin BMP co-receptor	Mus musculus	174-177
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	227-231	hepcidin antimicrobial peptide	Mus musculus	98-102
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	227-231	homeostatic iron regulator	Mus musculus	160-163
16132052-5	2005	In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	227-231	hemojuvelin BMP co-receptor	Mus musculus	174-177
16223494-0	2005	The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity.	Iron	99-103	Cch1p	Saccharomyces cerevisiae S288C	42-52
16103117-0	2005	Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells.	Iron	52-56	neogenin 1	Homo sapiens	32-40
16103117-12	2005	Immunoblot analysis of ferritin levels and transferrin-55Fe accumulation studies indicated that the HJV-induced increase in intracellular iron levels in human embryonic kidney 293 cells is dependent on the presence of neogenin in the cells, thus linking these two proteins to intracellular iron homeostasis.	Iron	138-142	neogenin 1	Homo sapiens	218-226
16309565-1	2005	Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1), which oxidatively degrades heme into iron, biliverdin, and carbon monoxide (CO), or adenoviral-mediated gene transfer of HO-1 inhibits neointima formation after experimental vascular injury.	Iron	113-117	heme oxygenase 1	Rattus norvegicus	51-67
15956281-0	2005	Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2).	Iron	13-17	iron responsive element binding protein 2	Mus musculus	69-94
15956281-0	2005	Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2).	Iron	13-17	iron responsive element binding protein 2	Mus musculus	96-100
15956281-2	2005	We report that young adult Irp2-/- mice display signs of iron mismanagement within the central iron recycling pathway in the mammalian body, the liver-bone marrow-spleen axis, with altered body iron distribution and compromised hematopoiesis.	Iron	57-61	iron responsive element binding protein 2	Mus musculus	27-31
15956281-2	2005	We report that young adult Irp2-/- mice display signs of iron mismanagement within the central iron recycling pathway in the mammalian body, the liver-bone marrow-spleen axis, with altered body iron distribution and compromised hematopoiesis.	Iron	95-99	iron responsive element binding protein 2	Mus musculus	27-31
15956281-2	2005	We report that young adult Irp2-/- mice display signs of iron mismanagement within the central iron recycling pathway in the mammalian body, the liver-bone marrow-spleen axis, with altered body iron distribution and compromised hematopoiesis.	Iron	95-99	iron responsive element binding protein 2	Mus musculus	27-31
16024130-1	2005	BACKGROUND/AIMS: Hepcidin is a liver-expressed peptide which plays an important role in the regulation of iron metabolism.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	17-25
16024130-6	2005	Hfe and beta2-microglobulin knockout mice have similar levels of prohepcidin protein expression as compared to wild-type mice despite increased iron stores.	Iron	144-148	homeostatic iron regulator	Mus musculus	0-3
16083989-3	2005	RESULTS: Iron initially accumulated in spleen macrophages but with subsequent increase in macrophage ferroportin and ferritin expression its content in the spleen decreased while a progressive storage of iron occurred within hepatocytes which was paralleled by a significant increase in hepcidin and hemojuvelin expression.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	287-295
16083989-3	2005	RESULTS: Iron initially accumulated in spleen macrophages but with subsequent increase in macrophage ferroportin and ferritin expression its content in the spleen decreased while a progressive storage of iron occurred within hepatocytes which was paralleled by a significant increase in hepcidin and hemojuvelin expression.	Iron	9-13	hemojuvelin BMP co-receptor	Mus musculus	300-311
16083989-6	2005	In parallel, the transfer of iron from the gut to the circulation is diminished which may be referred to interference of hepcidin with ferroportin mediated iron export, thus preventing body iron accumulation.	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	121-129
16083989-6	2005	In parallel, the transfer of iron from the gut to the circulation is diminished which may be referred to interference of hepcidin with ferroportin mediated iron export, thus preventing body iron accumulation.	Iron	156-160	hepcidin antimicrobial peptide	Mus musculus	121-129
16083989-6	2005	In parallel, the transfer of iron from the gut to the circulation is diminished which may be referred to interference of hepcidin with ferroportin mediated iron export, thus preventing body iron accumulation.	Iron	156-160	hepcidin antimicrobial peptide	Mus musculus	121-129
15933050-1	2005	Hepcidin is the principal iron regulatory hormone and its overproduction contributes to anemia of inflammation (AI).	Iron	26-30	hepcidin antimicrobial peptide	Mus musculus	0-8
15933050-2	2005	In vitro, hepcidin binds to and induces the degradation of the exclusive iron exporter ferroportin.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	10-18
15933050-4	2005	A single intraperitoneal injection of hepcidin caused a rapid fall of serum iron in a dose-dependent manner, with a 50-microg dose resulting in iron levels 80% lower than in control mice.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	38-46
15933050-4	2005	A single intraperitoneal injection of hepcidin caused a rapid fall of serum iron in a dose-dependent manner, with a 50-microg dose resulting in iron levels 80% lower than in control mice.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	38-46
15933050-9	2005	Our study highlights the central role of the hepcidin-ferroportin interaction in iron homeostasis.	Iron	81-85	hepcidin antimicrobial peptide	Mus musculus	45-53
16123136-7	2005	T cell antigen receptor recognition of MHC molecules independently of bound ligand has potential general implications in alloreactivity and identifies in the Hfe case a cognitive link supporting the concept that the immune system could be involved in the control of iron metabolism.	Iron	266-270	major histocompatibility complex, class I, C	Homo sapiens	39-42
16123136-7	2005	T cell antigen receptor recognition of MHC molecules independently of bound ligand has potential general implications in alloreactivity and identifies in the Hfe case a cognitive link supporting the concept that the immune system could be involved in the control of iron metabolism.	Iron	266-270	homeostatic iron regulator	Mus musculus	158-161
15908475-2	2005	Based on the fate of iron in airway epithelial cells, we postulated that divalent metal transporter-1 (DMT1) participates in detoxification of metal associated with air pollution particles.	Iron	21-25	RoBo-1	Rattus norvegicus	73-101
15908475-2	2005	Based on the fate of iron in airway epithelial cells, we postulated that divalent metal transporter-1 (DMT1) participates in detoxification of metal associated with air pollution particles.	Iron	21-25	RoBo-1	Rattus norvegicus	103-107
15908475-4	2005	Preexposure of normal rats to iron in vivo increased expression of the isoform of DMT1 protein that lacked an iron-response element (-IRE), accelerated metal transport out of the lung, and decreased injury after particle exposure.	Iron	30-34	RoBo-1	Rattus norvegicus	82-86
15908475-4	2005	Preexposure of normal rats to iron in vivo increased expression of the isoform of DMT1 protein that lacked an iron-response element (-IRE), accelerated metal transport out of the lung, and decreased injury after particle exposure.	Iron	110-114	RoBo-1	Rattus norvegicus	82-86
15908475-7	2005	Also, DMT1 mRNA and protein expression for the -IRE isoform increased or decreased in these cells when exposed to iron or vanadium, respectively.	Iron	114-118	RoBo-1	Rattus norvegicus	6-10
16154838-8	2005	RESULTS: Hepc RNA was reduced after phlebotomy and increased in iron overload.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	9-13
16154838-13	2005	In parenteral iron overload, Tfr2 gene and protein expression decreased concomitant to the increase in Hepc, while Hfe RNA remained constant.	Iron	14-18	transferrin receptor 2	Mus musculus	29-33
16154838-13	2005	In parenteral iron overload, Tfr2 gene and protein expression decreased concomitant to the increase in Hepc, while Hfe RNA remained constant.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	103-107
15921699-3	2005	MATERIALS AND METHODS: Hfe-/- mice (a murine homologue of hemochromatosis) abnormally accumulate iron in their tissues.	Iron	97-101	homeostatic iron regulator	Mus musculus	23-26
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	145-149	ferric reduction oxidase 5	Arabidopsis thaliana	85-91
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	145-149	ferric reduction oxidase 7	Arabidopsis thaliana	93-99
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	145-149	ferric reduction oxidase 8	Arabidopsis thaliana	104-110
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	264-268	ferric reduction oxidase 5	Arabidopsis thaliana	85-91
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	264-268	ferric reduction oxidase 7	Arabidopsis thaliana	93-99
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	159-163	ferric reduction oxidase 5	Arabidopsis thaliana	219-225
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	159-163	ferric reduction oxidase 6	Arabidopsis thaliana	227-233
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	159-163	ferric reduction oxidase 7	Arabidopsis thaliana	235-241
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	159-163	ferric reduction oxidase 8	Arabidopsis thaliana	246-252
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	270-274	ferric reduction oxidase 5	Arabidopsis thaliana	219-225
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	270-274	ferric reduction oxidase 6	Arabidopsis thaliana	227-233
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	270-274	ferric reduction oxidase 7	Arabidopsis thaliana	235-241
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	270-274	ferric reduction oxidase 8	Arabidopsis thaliana	246-252
16076215-3	2005	Here, we report the characterization of IroD and IroE as esterases for the apo and Fe(3+)-bound forms of Ent, MGE, DGE, and TGE, and we compare their activities with those of Fes, the previously characterized enterobactin esterase.	Iron	175-178	IroD	Escherichia coli	40-44
16076215-4	2005	IroD hydrolyzes both apo and Fe(3+)-bound siderophores distributively to generate DHB-Ser and/or Glc-DHB-Ser, with higher catalytic efficiencies (k(cat)/K(m)) on Fe(3+)-bound forms, suggesting that IroD is the ferric MGE/DGE esterase responsible for cytoplasmic iron release.	Iron	262-266	IroD	Escherichia coli	0-4
15929988-2	2005	Activation of TRAP is associated with the redox state of the di-iron metal center as well as with limited proteolytic cleavage in an exposed loop domain.	Iron	64-68	acid phosphatase 5, tartrate resistant	Rattus norvegicus	14-18
16043695-9	2005	We conclude that, through Nef and HFE, HIV-1 directly regulates cellular iron metabolism, possibly benefiting viral growth.	Iron	73-77	Nef	Human immunodeficiency virus 1	26-29
16158230-1	2005	FhuD is a periplasmic binding protein (PBP) that, under iron-limiting conditions, transports various hydroxamate-type siderophores from the outer membrane receptor (FhuA) to the inner membrane ATP-binding cassette transporter (FhuBC).	Iron	56-60	phosphatidylethanolamine binding protein 1	Homo sapiens	10-37
16158230-1	2005	FhuD is a periplasmic binding protein (PBP) that, under iron-limiting conditions, transports various hydroxamate-type siderophores from the outer membrane receptor (FhuA) to the inner membrane ATP-binding cassette transporter (FhuBC).	Iron	56-60	phosphatidylethanolamine binding protein 1	Homo sapiens	39-42
16075054-4	2005	These mutant mice will allow further investigation into the role of HJV in the regulation of iron homeostasis, a role that to date remains elusive.	Iron	93-97	hemojuvelin BMP co-receptor	Mus musculus	68-71
16075058-0	2005	Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.	Iron	37-41	hemojuvelin BMP co-receptor	Mus musculus	0-11
16075058-0	2005	Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.	Iron	84-88	hemojuvelin BMP co-receptor	Mus musculus	0-11
16075058-2	2005	Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin.	Iron	8-12	hepcidin antimicrobial peptide	Mus musculus	127-135
16075058-2	2005	Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	127-135
16075058-2	2005	Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	127-135
16075058-4	2005	Here we show that, within the liver, mouse Hjv is selectively expressed by periportal hepatocytes and also that Hjv-mutant mice exhibit iron overload as well as a dramatic decrease in hepcidin expression.	Iron	136-140	hemojuvelin BMP co-receptor	Mus musculus	43-46
16075058-4	2005	Here we show that, within the liver, mouse Hjv is selectively expressed by periportal hepatocytes and also that Hjv-mutant mice exhibit iron overload as well as a dramatic decrease in hepcidin expression.	Iron	136-140	hemojuvelin BMP co-receptor	Mus musculus	112-115
16075058-5	2005	Our findings define a key role for Hjv in dietary iron sensing and also reveal that cytokine-induced inflammation regulates hepcidin expression through an Hjv-independent pathway.	Iron	50-54	hemojuvelin BMP co-receptor	Mus musculus	35-38
16075059-5	2005	We have disrupted the murine Hjv gene and shown that Hjv-/- mice have markedly increased iron deposition in liver, pancreas, and heart but decreased iron levels in tissue macrophages.	Iron	89-93	hemojuvelin BMP co-receptor	Mus musculus	29-32
16075059-5	2005	We have disrupted the murine Hjv gene and shown that Hjv-/- mice have markedly increased iron deposition in liver, pancreas, and heart but decreased iron levels in tissue macrophages.	Iron	89-93	hemojuvelin BMP co-receptor	Mus musculus	53-56
16075059-5	2005	We have disrupted the murine Hjv gene and shown that Hjv-/- mice have markedly increased iron deposition in liver, pancreas, and heart but decreased iron levels in tissue macrophages.	Iron	149-153	hemojuvelin BMP co-receptor	Mus musculus	53-56
16024802-3	2005	Since we found that TNF-induced LIP in L929 cells is primarily furnished by intracellular storage iron, the lesser induction of LIP in H-ferritin-deficient cells results from a reduction of intracellular iron storage caused by less H-ferritin.	Iron	204-208	ferritin heavy polypeptide 1	Mus musculus	135-145
16024809-1	2005	The yeast Saccharomyces cerevisiae contains a pair of paralogous iron-responsive transcription activators, Aft1 and Aft2.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	107-111
27429427-18	2017	All explored iron biomarkers, including CHr, were affected by inflammation and should be adjusted.	Iron	13-17	chromate resistance; sulfate transport	Homo sapiens	40-43
16024809-2	2005	Aft1 activates the cell surface iron uptake systems in iron depletion, while the role of Aft2 remains poorly understood.	Iron	32-36	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
28236214-9	2017	Mutant Atx3 and alpha-Syn also potentiated altered redox status induced by iron and rotenone, a hint to how these proteins might influence neuronal dysfunction under pro-oxidant conditions.	Iron	75-79	ataxin 3	Homo sapiens	7-11
16024809-2	2005	Aft1 activates the cell surface iron uptake systems in iron depletion, while the role of Aft2 remains poorly understood.	Iron	55-59	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
16024809-3	2005	This study compares the functions of Aft1 and Aft2 in regulating the transcription of genes involved in iron homeostasis, with reference to the presence/absence of the paralog.	Iron	104-108	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	37-41
16024809-7	2005	Computer analysis found different cis-regulatory elements for Aft1 and Aft2, and transcription analysis using variants of the FET3 promoter indicated that Aft1 is more specific for the canonical iron-responsive element TGCACCC than is Aft2.	Iron	195-199	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	155-159
16024809-8	2005	Finally, the absence of either Aft1 or Aft2 showed an iron-dependent increase in the amount of the remaining paralog.	Iron	54-58	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	31-35
28426722-3	2017	Previous studies suggested that mNT and NAF-1 could function in the same pathway in mammalian cells, preventing the over-accumulation of iron and reactive oxygen species (ROS) in mitochondria.	Iron	137-141	CDGSH iron sulfur domain 2	Homo sapiens	40-45
16075245-1	2005	Absorption of iron occurs by duodenal enterocytes, involving uptake by the divalent metal transporter-1 (DMT1) and release by ferroportin.	Iron	14-18	RoBo-1	Rattus norvegicus	75-103
16075245-1	2005	Absorption of iron occurs by duodenal enterocytes, involving uptake by the divalent metal transporter-1 (DMT1) and release by ferroportin.	Iron	14-18	RoBo-1	Rattus norvegicus	105-109
16075245-12	2005	Surface binding of Fe(II) and iron transport V(max) were reduced by 50%, indicating that the antibody removed membrane-bound DMT1.	Iron	30-34	RoBo-1	Rattus norvegicus	125-129
28426722-7	2017	Our study highlights the possibility that mNT and NAF-1 function as part of an iron-sulfur (2Fe-2S) cluster relay to maintain the levels of iron and Fe-S clusters under control in the mitochondria of mammalian cells, thereby preventing the activation of apoptosis and/or autophagy and supporting cellular proliferation.	Iron	79-83	CDGSH iron sulfur domain 2	Homo sapiens	50-55
28426722-7	2017	Our study highlights the possibility that mNT and NAF-1 function as part of an iron-sulfur (2Fe-2S) cluster relay to maintain the levels of iron and Fe-S clusters under control in the mitochondria of mammalian cells, thereby preventing the activation of apoptosis and/or autophagy and supporting cellular proliferation.	Iron	140-144	CDGSH iron sulfur domain 2	Homo sapiens	50-55
15946650-1	2005	High affinity iron uptake in yeast is carried out by a multicomponent system formed by the ferroxidase Fet3p and the iron permease Ftr1p.	Iron	14-18	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	131-136
28426722-7	2017	Our study highlights the possibility that mNT and NAF-1 function as part of an iron-sulfur (2Fe-2S) cluster relay to maintain the levels of iron and Fe-S clusters under control in the mitochondria of mammalian cells, thereby preventing the activation of apoptosis and/or autophagy and supporting cellular proliferation.	Iron	149-153	CDGSH iron sulfur domain 2	Homo sapiens	50-55
28397746-1	2017	The peptide hormone hepcidin is a key controller of systemic iron homeostasis, and its expression in the liver is mainly regulated by bone morphogenetic proteins (BMPs), which are heparin binding proteins.	Iron	61-65	hepcidin antimicrobial peptide	Mus musculus	20-28
15917236-5	2005	Here, we show that atovaquone blocks this domain movement by locking the iron-sulfur subunit in its cytochrome b-binding conformation.	Iron	73-77	mitochondrially encoded cytochrome b	Homo sapiens	100-112
15932798-4	2005	Hepcidin has been hypothesized to be the mediator of iron- and inflammation-induced changes in iron metabolism.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	0-8
28380382-1	2017	The iron-sulfur (Fe-S) cluster of the Rieske protein, UQCRFS1, is essential for Complex III (CIII) activity, though the mechanism for Fe-S cluster transfer has not previously been elucidated.	Iron	17-21	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Homo sapiens	54-61
15932798-4	2005	Hepcidin has been hypothesized to be the mediator of iron- and inflammation-induced changes in iron metabolism.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	0-8
15932798-5	2005	The molecular details of the connection between iron metabolism, hepcidin and inflammation have become clearer with the recent finding of hepcidin-induced internalization and degradation of FPN1.	Iron	48-52	hepcidin antimicrobial peptide	Mus musculus	138-146
15917335-8	2005	Increased Fe(PO4) was associated with decreased eGFR, and both increased FGF-23 and PTH were independently associated with increased Fe(PO4).	Iron	133-135	fibroblast growth factor 23	Homo sapiens	73-79
15917335-10	2005	It is concluded that FGF-23 levels increase early in CKD before the development of serum mineral abnormalities and are independently associated with serum phosphate, Fe(PO4), and calcitriol deficiency.	Iron	166-168	fibroblast growth factor 23	Homo sapiens	21-27
28380382-1	2017	The iron-sulfur (Fe-S) cluster of the Rieske protein, UQCRFS1, is essential for Complex III (CIII) activity, though the mechanism for Fe-S cluster transfer has not previously been elucidated.	Iron	134-138	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Homo sapiens	54-61
16000726-0	2005	Functions of the siderophore esterases IroD and IroE in iron-salmochelin utilization.	Iron	56-60	IroD	Escherichia coli	39-43
28380382-2	2017	Recent studies have shown that the co-chaperone HSC20, essential for Fe-S cluster biogenesis of SDHB, directly binds LYRM7, formerly described as a chaperone that stabilizes UQCRFS1 prior to its insertion into CIII.	Iron	69-73	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	96-100
28380382-2	2017	Recent studies have shown that the co-chaperone HSC20, essential for Fe-S cluster biogenesis of SDHB, directly binds LYRM7, formerly described as a chaperone that stabilizes UQCRFS1 prior to its insertion into CIII.	Iron	69-73	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Homo sapiens	174-181
28380382-3	2017	Here we report that a transient subcomplex involved in CIII assembly, composed of LYRM7 bound to UQCRFS1, interacts with components of an Fe-S transfer complex, consisting of HSC20, its cognate chaperone HSPA9, and the holo-scaffold ISCU.	Iron	138-140	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Homo sapiens	97-104
16121509-2	2005	The zero-valent iron shows promising results as a reductant of hexavalent chromium (Cr+6) to trivalent chromium (Cr+3), capable of 100% reduction.	Iron	16-20	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	84-88
16121509-7	2005	It is proposed that, for waste with high chromium concentration, zero-valent iron is an efficient reductant and can be used for reduction of Cr+6.	Iron	77-81	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	141-145
28346059-5	2017	UGT1A1 rs887829TT (p = 0.002) and CYP1A2 rs762551CC (p = 0.019) resulted as predictive factor of ferritin levels and CYP1A1 rs2606345CA/AA (p = 0.021) and CYP1A2 rs762551AC/CC (p = 0.027) of liver iron concentration.	Iron	197-201	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
15925003-8	2005	In contrast, genes involved in iron utilization (e.g., siderophore, iron transporter and ferroxidase) showed enhanced expression in synthetic medium, suggesting that iron starvation occurred.	Iron	31-35	ferroxidase	Saccharomyces cerevisiae S288C	89-100
28315258-4	2017	In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively.	Iron	89-93	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	61-65
15976298-0	2005	Sound velocities of hot dense iron: Birch"s law revisited.	Iron	30-34	alcohol dehydrogenase iron containing 1	Homo sapiens	20-23
15737887-0	2005	New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis.	Iron	18-22	homeostatic iron regulator	Mus musculus	60-63
15737887-2	2005	Four genes are responsible for the distinct types of non-HFE haemochromatosis: hepcidin and hemojuvelin are the genes involved in type 2 or juvenile haemochromatosis, transferrin receptor 2 is involved in type 3 haemochromatosis, and ferroportin 1 is mutated in type 4, the atypical dominant form of primary iron overload.	Iron	308-312	homeostatic iron regulator	Mus musculus	57-60
28315258-4	2017	In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively.	Iron	133-137	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	61-65
15737887-2	2005	Four genes are responsible for the distinct types of non-HFE haemochromatosis: hepcidin and hemojuvelin are the genes involved in type 2 or juvenile haemochromatosis, transferrin receptor 2 is involved in type 3 haemochromatosis, and ferroportin 1 is mutated in type 4, the atypical dominant form of primary iron overload.	Iron	308-312	hepcidin antimicrobial peptide	Mus musculus	79-87
15737887-2	2005	Four genes are responsible for the distinct types of non-HFE haemochromatosis: hepcidin and hemojuvelin are the genes involved in type 2 or juvenile haemochromatosis, transferrin receptor 2 is involved in type 3 haemochromatosis, and ferroportin 1 is mutated in type 4, the atypical dominant form of primary iron overload.	Iron	308-312	hemojuvelin BMP co-receptor	Mus musculus	92-103
15737887-2	2005	Four genes are responsible for the distinct types of non-HFE haemochromatosis: hepcidin and hemojuvelin are the genes involved in type 2 or juvenile haemochromatosis, transferrin receptor 2 is involved in type 3 haemochromatosis, and ferroportin 1 is mutated in type 4, the atypical dominant form of primary iron overload.	Iron	308-312	transferrin receptor 2	Mus musculus	167-189
28315258-7	2017	Various conserved proteins, such as ABC mitochondrial transporter Atm1 and, for Aft1/Aft2, monothiol glutaredoxins Grx3 and Grx4 are implicated in this iron-signaling pathway.	Iron	152-156	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	80-84
15737887-4	2005	A milestone was the discovery that hepcidin, the key iron regulator in mice, is the gene mutated in the most severe, juvenile form of haemochromatosis.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	35-43
15737887-5	2005	This finding indicates a fundamental role of hepcidin in inhibiting both iron absorption from duodenal cells and iron release from macrophages, and has opened up a new view of haemochromatosis as a disorder of hepcidin.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	45-53
28315258-7	2017	Various conserved proteins, such as ABC mitochondrial transporter Atm1 and, for Aft1/Aft2, monothiol glutaredoxins Grx3 and Grx4 are implicated in this iron-signaling pathway.	Iron	152-156	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	115-119
15737887-5	2005	This finding indicates a fundamental role of hepcidin in inhibiting both iron absorption from duodenal cells and iron release from macrophages, and has opened up a new view of haemochromatosis as a disorder of hepcidin.	Iron	113-117	hepcidin antimicrobial peptide	Mus musculus	45-53
28192097-6	2017	Iron overload led to increased plasma non-transferrin bound iron, oxidative stress, and the impairments of HRV and left ventricular function, cardiac mitochondrial function and mitochondrial dynamics, and decreased complex IV in thalassemic mice.	Iron	0-4	transferrin	Mus musculus	42-53
15880490-9	2005	By using basal c-Fos expression as a marker for cellular activation we found a significant reduction in c-Fos expression in the central nucleus of the inferior colliculus in iron-adequate rat pups exposed to CO. By contrast, rather than being reduced, c-Fos expression in the ARIDCO group is the same as for controls.	Iron	174-178	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	15-20
15880490-9	2005	By using basal c-Fos expression as a marker for cellular activation we found a significant reduction in c-Fos expression in the central nucleus of the inferior colliculus in iron-adequate rat pups exposed to CO. By contrast, rather than being reduced, c-Fos expression in the ARIDCO group is the same as for controls.	Iron	174-178	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-109
15880490-9	2005	By using basal c-Fos expression as a marker for cellular activation we found a significant reduction in c-Fos expression in the central nucleus of the inferior colliculus in iron-adequate rat pups exposed to CO. By contrast, rather than being reduced, c-Fos expression in the ARIDCO group is the same as for controls.	Iron	174-178	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-109
16008092-6	2005	LeODD is homologous to 2-oxoglutarate-dependent dioxygenase genes, and the key amino acid residues in the binding sites for ferrous iron and 2-oxoglutarate are completely conserved.	Iron	132-136	2-oxoglutarate-dependent dioxygenase	Solanum lycopersicum	0-5
28192097-6	2017	Iron overload led to increased plasma non-transferrin bound iron, oxidative stress, and the impairments of HRV and left ventricular function, cardiac mitochondrial function and mitochondrial dynamics, and decreased complex IV in thalassemic mice.	Iron	60-64	transferrin	Mus musculus	42-53
28004874-3	2017	Here we apply ultrafast XUV (extreme ultraviolet) photoemission spectroscopy to track the low-to-high spin dynamics in the aqueous iron tris-bipyridine complex, [Fe(bpy)3 ]2+ , by monitoring the transient electron density distribution among excited states with femtosecond time resolution.	Iron	131-135	spindlin 1	Homo sapiens	102-106
15767258-10	2005	A different role for Yfh1p was observed under conditions of low mitochondrial iron and aerobic growth (revealed in the DeltaDeltaDelta), acting to protect bioavailable iron within mitochondria and to facilitate its use for heme synthesis.	Iron	78-82	ferroxidase	Saccharomyces cerevisiae S288C	21-26
15767258-10	2005	A different role for Yfh1p was observed under conditions of low mitochondrial iron and aerobic growth (revealed in the DeltaDeltaDelta), acting to protect bioavailable iron within mitochondria and to facilitate its use for heme synthesis.	Iron	168-172	ferroxidase	Saccharomyces cerevisiae S288C	21-26
28085239-3	2017	Electrochemical characterization of the Ni4.5Co4.5S8 and g-Fe3C/Fe materials showed that both have high specific capacities (206 mAh g-1 and 147 mAh g-1 at 1 A g-1) and excellent rate capabilities (~95% and ~83% retention at 20 A g-1, respectively).	Iron	59-61	proline rich protein BstNI subfamily 3	Homo sapiens	133-163
15616221-2	2005	Previous studies suggested that cubilin, a multiligand receptor for vitamin, iron, and protein uptake in the adult, might be important in this process, but the onset of its expression and function is not known.	Iron	77-81	cubilin	Homo sapiens	32-39
27995414-1	2017	Recent investigation has shown that the liver-derived iron-regulating hormone, hepcidin, can potentiate intestinal calcium absorption in hemizygous beta-globin knockout thalassemic (BKO) mice.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	79-87
15826185-1	2005	Poly(benzyl ether) dendrons having a focal triazole unit (Gntrz: trz = triazole; n = generation number = 0-2) were found to react with (MeSO(3))(2)Fe to form dendritic coordination polymers ([Fe(Gntrz)(3)](MeSO(3))(2).2H(2)O) that undergo the thermal spin transition.	Iron	147-149	spindlin 1	Homo sapiens	251-255
15691834-5	2005	Lipocalin 2 action was enhanced by iron-siderophore.	Iron	35-39	lipocalin 2	Homo sapiens	0-11
27096259-5	2017	The complete sequencing of the iron-responsive element (IRE) of the FTL gene was analyzed using bi-directional genomic sequencing.	Iron	31-35	ferritin light chain	Homo sapiens	68-71
15649888-0	2005	Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis.	Iron	18-22	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	44-48
27417666-1	2017	The host-guest composites of Hofmann-type iron(II) spin-transition (ST) porous coordination polymers incorporating guest molecules show guest-dependent ST behavior in accordance with the respective guest species, which may be a gas, solvent, halogen, or organic molecule.	Iron	42-46	spindlin 1	Homo sapiens	51-55
16046841-9	2005	Hypoxia preconditioning can be mimicked by iron chelators like desferrioxamine and transition metals like cobalt chloride that inhibit prolyl hydroxylases, increase HIF-1alpha levels in the brain, and produce protection of the brain against combined hypoxia-ischemia 24 h later.	Iron	43-47	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	165-175
15726660-4	2005	Hepcidin messenger RNA (mRNA) expression was studied by Northern blot and reverse transcriptase polymerase chain reaction analysis in mice that were treated with 40 mg/kg gadolinium (III) chloride (GdCl(3)) as a Kupffer cell inactivating agent and subjected to inflammatory challenges with either lipopolysaccharide (LPS) and turpentine or iron overload by iron-dextran administration.	Iron	340-344	hepcidin antimicrobial peptide	Mus musculus	0-8
28223994-7	2017	We previously reported that AtIRT1, when expressed together with AtNAS1 and PvFERRITIN (PvFER) in high-iron (NFP) rice, has a synergistic effect of further increasing the iron concentration of polished rice grains.	Iron	103-107	iron-regulated transporter 1	Arabidopsis thaliana	28-34
15664434-5	2005	Paraquat induced a time-dependent increase in the binding of iron regulatory protein 1 (IRP1) to iron-responsive element (IRE), and the enhanced IRP1 activity continued over 24 h. On the other hand, no induction of increased IRP1 binding to IRE was observed in rodent cells exposed to formaldehyde.	Iron	61-65	aconitase 1	Mus musculus	88-92
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	66-70	aconitase 1	Mus musculus	100-104
28223994-7	2017	We previously reported that AtIRT1, when expressed together with AtNAS1 and PvFERRITIN (PvFER) in high-iron (NFP) rice, has a synergistic effect of further increasing the iron concentration of polished rice grains.	Iron	171-175	iron-regulated transporter 1	Arabidopsis thaliana	28-34
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	66-70	iron responsive element binding protein 2	Mus musculus	109-113
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	aconitase 1	Mus musculus	66-98
28223994-10	2017	All the single insertion transgenic lines have significant increases of iron concentration, both in polished and unpolished grains, but the concerted expression of AtIRT1, AtNAS1, and PvFER resulted to be a more effective strategy in achieving the highest iron increases of up to 10.46 mug/g dry weight.	Iron	256-260	iron-regulated transporter 1	Arabidopsis thaliana	164-170
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	aconitase 1	Mus musculus	100-104
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	iron responsive element binding protein 2	Mus musculus	109-113
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	aconitase 1	Mus musculus	66-98
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	aconitase 1	Mus musculus	100-104
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	iron responsive element binding protein 2	Mus musculus	109-113
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	79-83	transferrin	Mus musculus	202-213
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	aconitase 1	Mus musculus	66-98
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	aconitase 1	Mus musculus	100-104
15710243-5	2005	We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin.	Iron	153-157	iron responsive element binding protein 2	Mus musculus	109-113
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	79-83	transferrin	Mus musculus	215-217
15710243-10	2005	However, the activities of IRP1 and IRP2, and protein levels of TfR1 and ferritin, were still significantly lower in iron-depleted ScN2a cells as compared to the N2a cells, suggesting lower need for iron in ScN2a cells.	Iron	117-121	aconitase 1	Mus musculus	27-31
15710243-10	2005	However, the activities of IRP1 and IRP2, and protein levels of TfR1 and ferritin, were still significantly lower in iron-depleted ScN2a cells as compared to the N2a cells, suggesting lower need for iron in ScN2a cells.	Iron	117-121	iron responsive element binding protein 2	Mus musculus	36-40
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	transferrin	Mus musculus	202-213
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	transferrin	Mus musculus	215-217
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	transferrin	Mus musculus	202-213
15479721-0	2005	Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	0-8
28129513-1	2017	Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron from their host using surface receptors that have the ability to hijack iron from the iron-sequestering host proteins transferrin (Tf) and lactoferrin (Lf).	Iron	156-160	transferrin	Mus musculus	215-217
15479721-5	2005	Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	41-49
28129513-2	2017	The process of acquiring iron from Tf has been well-characterized, including the role of the surface lipoprotein transferrin-binding protein B (TbpB).	Iron	25-29	transferrin	Mus musculus	35-37
15479721-5	2005	Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	41-49
15479721-6	2005	Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	0-8
28239795-1	2017	We studied cytotoxic activity of a new NO-releasing tetranitrosyl binuclear iron complex with cysteamine (CysAm) for human tumor cells, the relationship between the expression of O6-methylguanine-DNA methyltransferase (MGMT) and cell sensitivity to CysAm, and apoptosis-inducing capacity of this preparation.	Iron	76-80	O-6-methylguanine-DNA methyltransferase	Homo sapiens	219-223
15660134-4	2005	Mutations in critical cysteine residues of Rli1p abolish association with Fe/S clusters and lead to loss of cell viability.	Iron	74-76	ATP binding cassette subfamily E member 1	Homo sapiens	43-48
15660134-5	2005	Hence, the essential character of Fe/S clusters in Rli1p explains the indispensable character of mitochondria in eukaryotes.	Iron	34-36	ATP binding cassette subfamily E member 1	Homo sapiens	51-56
27376881-5	2017	In contrast to the upregulation of the nonreductive iron uptake genes ARN1 and FIT2 by ALA, the quantity of FET3 and FTR1 transcripts encoding the high-affinity iron uptake reductive pathway decreased.	Iron	161-165	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	117-121
27545647-2	2017	Intracellular iron availability is secured by two mRNA-binding iron-regulatory proteins (IRPs), IRP1 and IRP2.	Iron	14-18	aconitase 1	Mus musculus	96-100
15732619-1	2005	UNLABELLED: This article reviews a study, published in Clinical and Laboratory Haematology (2003), which looked at using iron-rich spa water (Spatone) as a prophylaxis against iron deficiency in pregnancy.	Iron	121-125	surfactant protein A2	Homo sapiens	131-134
16339690-0	2005	Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	22-30
16339690-0	2005	Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	22-30
16339690-2	2005	Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	100-108
27545647-2	2017	Intracellular iron availability is secured by two mRNA-binding iron-regulatory proteins (IRPs), IRP1 and IRP2.	Iron	14-18	iron responsive element binding protein 2	Mus musculus	105-109
16339690-2	2005	Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	110-114
16339690-3	2005	In mice, iron overload leads to overexpression of Hamp, while Hamp-knockout mice suffer from hemochromatosis.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	50-54
27848940-4	2017	Our objective was to evaluate the effect of administration of intravenous iron polymaltose on intact and c-terminal FGF23 (i:cFGF23) ratios in two independent cohorts of patients, iron-deficient but non-inflamed patients and haemodialysis (HD)-dependent patients, and to examine the balance of synthesis and degradation.	Iron	74-78	fibroblast growth factor 23	Homo sapiens	116-121
16339690-4	2005	The aim of this study is to investigate Hamp in the mouse model of beta-thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.	Iron	155-159	hepcidin antimicrobial peptide	Mus musculus	130-134
27848940-8	2017	CONCLUSIONS: Dysregulation of intracellular FGF23-processing mechanisms may be related to iron deficiency per se rather than iron repletion with iron polymaltose.	Iron	90-94	fibroblast growth factor 23	Homo sapiens	44-49
15635223-0	2005	Amidino-containing Schiff base copper(II) and iron(III) chelates as a thrombin inhibitor.	Iron	46-50	coagulation factor II, thrombin	Bos taurus	70-78
27853975-0	2017	Laser Desorption Ionization Quadrupole Ion Trap Time-of-Flight Mass Spectrometry of Au m Fe n+/- Clusters Generated from Gold-Iron Nanoparticles and their Giant Nanoflowers.	Iron	89-91	TRAP	Homo sapiens	43-47
16103673-3	2005	METHODS: Using quantitative RT-PCR, the iron-dependent hepatic expression patterns of HAMP, HJV, and TFR2 were evaluated in human and murine HFE-related hemochromatosis.	Iron	40-44	homeostatic iron regulator	Mus musculus	141-144
16103673-4	2005	RESULTS: The overall level of hepatic HAMP expression in human and murine HFE-related hemochromatosis is impaired but can still be modulated by iron stores.	Iron	144-148	homeostatic iron regulator	Mus musculus	74-77
27853975-0	2017	Laser Desorption Ionization Quadrupole Ion Trap Time-of-Flight Mass Spectrometry of Au m Fe n+/- Clusters Generated from Gold-Iron Nanoparticles and their Giant Nanoflowers.	Iron	126-130	TRAP	Homo sapiens	43-47
27864295-1	2017	Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance.	Iron	107-111	hepcidin antimicrobial peptide	Mus musculus	120-128
27738674-3	2017	In Saccharomyces cerevisiae, de novo FeS-cluster formation is accomplished through coordinated assembly with the substrates iron and sulfur by the scaffold assembly protein "Isu1".	Iron	124-128	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	174-179
16054772-6	2005	Particular attention was given to Ndrg1, expressed as early as 24 h after treatment, which can be regulated by iron and is involved with blocking of the cell cycle.	Iron	111-115	N-myc downstream regulated 1	Homo sapiens	34-39
28377980-2	2017	In addition to stimulation by phosphate, FGF23 positively responds to iron deficiency anemia and hypoxia in rodent models and in humans.	Iron	70-74	fibroblast growth factor 23	Homo sapiens	41-46
15717636-1	2005	BACKGROUND: We previously showed that the content of reticulocyte hemoglobin (CHr) is a reliable measure of iron status in chronic dialysis patients with erythrocytopoiesis.	Iron	108-112	chromate resistance; sulfate transport	Homo sapiens	78-81
15717636-3	2005	We attempted to utilize the measurement of CHr levels to monitor iron status and clarify the changes in iron levels that occur as renal anemia progresses in patients with chronic renal failure (CRF).	Iron	65-69	chromate resistance; sulfate transport	Homo sapiens	43-46
15717636-11	2005	CONCLUSION: CHr is an easily measurable and trustworthy marker of iron status in nondialysis CRF patients.	Iron	66-70	chromate resistance; sulfate transport	Homo sapiens	12-15
15717636-12	2005	Moreover, the CHr level was also sensitive to iron alterations in nondialysis CRF patients receiving rHuEPO treatment, and thus, the CHr value could likely provide useful information regarding the need for iron supplementation.	Iron	46-50	chromate resistance; sulfate transport	Homo sapiens	14-17
15717636-12	2005	Moreover, the CHr level was also sensitive to iron alterations in nondialysis CRF patients receiving rHuEPO treatment, and thus, the CHr value could likely provide useful information regarding the need for iron supplementation.	Iron	206-210	chromate resistance; sulfate transport	Homo sapiens	14-17
15717636-12	2005	Moreover, the CHr level was also sensitive to iron alterations in nondialysis CRF patients receiving rHuEPO treatment, and thus, the CHr value could likely provide useful information regarding the need for iron supplementation.	Iron	206-210	chromate resistance; sulfate transport	Homo sapiens	133-136
28377980-10	2017	In summary, FGF23 can be driven by ectopic HIF1alpha activation under normal iron conditions in vitro, but factors independent of HIF1alpha activity after mature osteoblast formation are responsible for the disease phenotypes in Hyp mice in vivo.	Iron	77-81	fibroblast growth factor 23	Mus musculus	12-17
28073261-1	2017	Magnetic insulators, such as yttrium iron garnet (Y3Fe5O12), are ideal materials for ultralow power spintronics applications due to their low energy dissipation and efficient spin current generation and transmission.	Iron	37-41	spindlin 1	Homo sapiens	100-104
15607119-6	2004	Moreover, PCTH prevented the incorporation of (59)Fe into ferritin during Fe uptake from (59)Fe-labelled transferrin.	Iron	50-52	transferrin	Mus musculus	105-116
27918126-4	2017	Here, the synthesis of a versatile collection of trityl spin labels and their application in in vitro and in-cell trityl-iron distance measurements on a cytochrome P450 protein are described.	Iron	121-125	spindlin 1	Homo sapiens	56-60
15607119-6	2004	Moreover, PCTH prevented the incorporation of (59)Fe into ferritin during Fe uptake from (59)Fe-labelled transferrin.	Iron	74-76	transferrin	Mus musculus	105-116
15607119-6	2004	Moreover, PCTH prevented the incorporation of (59)Fe into ferritin during Fe uptake from (59)Fe-labelled transferrin.	Iron	74-76	transferrin	Mus musculus	105-116
15604406-2	2004	Although both IRPs can regulate expression of the same target genes, IRP2-/- mice significantly misregulate iron metabolism and develop neurodegeneration, whereas IRP1-/- mice are spared.	Iron	108-112	iron responsive element binding protein 2	Mus musculus	69-73
28425416-2	2017	Among them, GNPAT rs11558492 was proposed as genetic modifier of iron status, but results are still controversial.	Iron	65-69	glyceronephosphate O-acyltransferase	Homo sapiens	12-17
15556641-5	2004	FRU mutant plants were chlorotic, and the FRU gene was found necessary for induction of the essential iron mobilization genes FRO2 (ferric chelate reductase gene) and IRT1 (iron-regulated transporter gene).	Iron	102-106	iron-regulated transporter 1	Arabidopsis thaliana	167-171
27750167-11	2017	This first simultaneous evaluation of Hg methylation and sulfate-reduction and of the effect of iron and inhibitors on both processes suggest that SRB are important Hg methylators in mangrove sediments.	Iron	96-100	chaperonin containing TCP1 subunit 4	Homo sapiens	147-150
15251988-9	2004	Our investigation suggests Ndrg1 is a novel link between Fe metabolism and the control of proliferation.	Iron	57-59	N-myc downstream regulated 1	Homo sapiens	27-32
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	92-96	synemin	Homo sapiens	24-27
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	92-96	synemin	Homo sapiens	151-154
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	138-142	synemin	Homo sapiens	24-27
15560792-12	2004	A docking model of heme-Syn HO-1 and ferredoxin suggests indirect electron transfer from an iron-sulfur cluster in ferredoxin to the heme iron of heme-Syn HO-1.	Iron	138-142	synemin	Homo sapiens	151-154
27481658-0	2017	GNPAT p.D519G variant and iron metabolism during oral iron tolerance test.	Iron	54-58	glyceronephosphate O-acyltransferase	Homo sapiens	0-5
15804829-0	2004	Reversible hexa- to penta-coordination of the heme Fe atom modulates ligand binding properties of neuroglobin and cytoglobin.	Iron	51-53	neuroglobin	Homo sapiens	98-109
15804829-6	2004	Ngb and Cgb display the classical three-over-three alpha-helical fold of Hb and Mb, and are endowed with a hexa-coordinate heme-Fe atom, in their ferrous and ferric forms, having the heme distal HisE7 residue as the endogenous ligand.	Iron	128-130	neuroglobin	Homo sapiens	0-3
15804829-7	2004	Reversible hexa- to penta-coordination of the heme Fe atom modulates ligand binding properties of Ngb and Cygb.	Iron	51-53	neuroglobin	Homo sapiens	98-101
28042406-1	2017	Mutations in the C19orf12 gene are known to cause mitochondrial membrane protein-associated neurodegeneration (MPAN), which is a neurodegeneration with brain iron accumulation (NBIA) type 4 disorder.	Iron	158-162	chromosome 19 open reading frame 12	Homo sapiens	17-25
15258160-1	2004	Iron regulatory protein-1 (IRP-1) is a bifunctional [4Fe-4S] protein that functions as a cytosolic aconitase or as a trans-regulatory factor controlling iron homeostasis at a post-transcriptional level.	Iron	153-157	aconitase 1	Mus musculus	0-25
15258160-1	2004	Iron regulatory protein-1 (IRP-1) is a bifunctional [4Fe-4S] protein that functions as a cytosolic aconitase or as a trans-regulatory factor controlling iron homeostasis at a post-transcriptional level.	Iron	153-157	aconitase 1	Mus musculus	27-32
15258160-4	2004	We show that nitration of endogenous IRP-1 in NO-producing macrophages boosted to produce O*2- was accompanied by aconitase inhibition and impairment of its capacity to bind the iron-responsive element (IRE) of ferritin mRNA.	Iron	178-182	aconitase 1	Mus musculus	37-42
27733366-2	2016	Our objective was to determine how chronic kidney disease (CKD) and dietary iron intake affect FGF23 production and metabolism in wild-type (WT) and hepcidin knockout (HKO) mice.	Iron	76-80	fibroblast growth factor 23	Mus musculus	95-100
15258160-6	2004	Inclusion of cis-aconitate with cell extract to stabilize the [4Fe-4S] cluster of holo-IRP-1 rendered protein insensitive to nitration by peroxynitrite, suggesting that loss of [Fe-S] cluster and subsequent change of conformation are prerequisites for tyrosine nitration.	Iron	178-182	aconitase 1	Mus musculus	87-92
15258160-9	2004	Peroxidase-mediated nitration of critical tyrosine residues, by holding IRP-1 in an inactive state, may constitute, in activated macrophages, a self-protecting mechanism against iron-induced toxicity.	Iron	178-182	aconitase 1	Mus musculus	72-77
15172967-8	2004	Here we show that bleeding into a joint in vivo and iron in vitro result in increased expression of the p53-binding protein, mdm2.	Iron	52-56	MDM2 proto-oncogene	Homo sapiens	125-129
15172967-9	2004	Iron induced the expression of mdm2 by normal human synovial cells approximately 8-fold.	Iron	0-4	MDM2 proto-oncogene	Homo sapiens	31-35
15172967-11	2004	Iron, in vitro, induced the expression of mdm2.	Iron	0-4	MDM2 proto-oncogene	Homo sapiens	42-46
27733366-5	2016	Among the WT mice, in both the control and CKD groups, a low-iron compared with a standard-iron diet increased bone Fgf23 mRNA expression, C-terminal FGF23 (cFGF23) levels, and FGF23 cleavage as manifested by a lower percentage intact FGF23 (iFGF23).	Iron	61-65	fibroblast growth factor 23	Mus musculus	116-121
27733366-5	2016	Among the WT mice, in both the control and CKD groups, a low-iron compared with a standard-iron diet increased bone Fgf23 mRNA expression, C-terminal FGF23 (cFGF23) levels, and FGF23 cleavage as manifested by a lower percentage intact FGF23 (iFGF23).	Iron	61-65	fibroblast growth factor 23	Mus musculus	150-155
15514054-6	2004	The growth phenotype of crr1 strains results primarily from secondary iron deficiency owing to reduced ferroxidase abundance, suggesting a role for CRR1 in copper distribution to a multicopper ferroxidase involved in iron assimilation.	Iron	70-74	uncharacterized protein	Chlamydomonas reinhardtii	24-28
27733366-5	2016	Among the WT mice, in both the control and CKD groups, a low-iron compared with a standard-iron diet increased bone Fgf23 mRNA expression, C-terminal FGF23 (cFGF23) levels, and FGF23 cleavage as manifested by a lower percentage intact FGF23 (iFGF23).	Iron	61-65	fibroblast growth factor 23	Mus musculus	158-163
15338274-7	2004	In Africans with iron overload not related to the HFE gene, the possible involvement of the SLC40A1 and CYBRD1 genes was demonstrated for the first time.	Iron	17-21	cytochrome b reductase 1	Homo sapiens	104-110
15338274-8	2004	This study confirms the genetic heterogeneity of haemochromatosis and highlights the significance of CYBRD1 mutations in relation to iron overload.	Iron	133-137	cytochrome b reductase 1	Homo sapiens	101-107
27733366-5	2016	Among the WT mice, in both the control and CKD groups, a low-iron compared with a standard-iron diet increased bone Fgf23 mRNA expression, C-terminal FGF23 (cFGF23) levels, and FGF23 cleavage as manifested by a lower percentage intact FGF23 (iFGF23).	Iron	61-65	fibroblast growth factor 23	Mus musculus	158-163
27733366-6	2016	Independent of iron status, CKD was associated with inhibition of FGF23 cleavage.	Iron	15-19	fibroblast growth factor 23	Mus musculus	66-71
27733366-8	2016	Dietary iron content was more influential on FGF23 parameters than the presence or absence of hepcidin.	Iron	8-12	fibroblast growth factor 23	Mus musculus	45-50
15361144-0	2004	Nfu2: a scaffold protein required for [4Fe-4S] and ferredoxin iron-sulphur cluster assembly in Arabidopsis chloroplasts.	Iron	62-66	NIFU-like protein 2	Arabidopsis thaliana	0-4
27733366-10	2016	Therefore, in both the WT and HKO mouse models, dietary iron content and CKD affected FGF23 production and metabolism.	Iron	56-60	fibroblast growth factor 23	Mus musculus	86-91
27935134-14	2016	Iron accumulation has been attributed to suppression of hepcidin by oxidative stress.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	56-64
18969598-8	2004	This procedure was successfully applied to the determination of iron in tap and sewage water samples.	Iron	64-68	nuclear RNA export factor 1	Homo sapiens	72-75
27634155-1	2016	In this study, nanoscale zerovalent iron (NZVI) immobilized on biomass carbon was used for the high efficient removal of BDE 209.	Iron	36-40	homeobox D13	Homo sapiens	121-124
15087280-0	2004	ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction.	Iron	24-28	natriuretic peptide A	Rattus norvegicus	0-3
15087280-3	2004	Because HO-1 liberates bound iron, the aim of our study was to determine whether ANP affects iron regulatory protein (IRP) activity and, thus, the levels of ferritin.	Iron	29-33	heme oxygenase 1	Rattus norvegicus	8-12
27825818-2	2016	Ngb is a monomeric 3/3 globin structurally similar to myoglobin and to the alpha- and beta-chains of hemoglobin, however it displays a bis-histidyl six-coordinate heme-Fe atom.	Iron	168-170	neuroglobin	Homo sapiens	0-3
15155457-3	2004	The aim of this study was to examine the importance of NTBI in the pathogenesis of hepatic iron loading in Hfe knockout mice.	Iron	91-95	homeostatic iron regulator	Mus musculus	107-110
15155457-9	2004	We conclude that NTBI uptake by hepatocytes from Hfe knockout mice contributed to hepatic iron loading.	Iron	90-94	homeostatic iron regulator	Mus musculus	49-52
27825818-3	2016	Therefore, ligand binding to the Ngb metal center is limited from the dissociation of the distal His(E7)64-Fe bond.	Iron	107-109	neuroglobin	Homo sapiens	33-36
27694803-1	2016	Diphthamide and the tRNA wobble uridine modifications both require diphthamide biosynthesis 3 (Dph3) protein as an electron donor for the iron-sulfur clusters in their biosynthetic enzymes.	Iron	138-142	diphthamide biosynthesis 3	Homo sapiens	95-99
21706744-4	2004	Ngb and Cygb display the classical three-on-three alpha-helical globin fold and are endowed with a hexa-coordinate heme Fe atom, in both their ferrous and ferric forms, having the heme distal HisE7 residue as the endogenous sixth ligand.	Iron	120-122	neuroglobin	Homo sapiens	0-3
21706744-5	2004	Reversible intramolecular hexa- to penta-coordination of the heme Fe atom modulates Ngb and Cygb ligand-binding properties.	Iron	66-68	neuroglobin	Homo sapiens	84-87
27901468-0	2016	Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals.	Iron	31-35	pyruvate dehydrogenase kinase 1	Homo sapiens	49-53
15480904-1	2004	BACKGROUND: Reticulocyte hemoglobin content (CHr) has recently become available as a direct marker of the iron status in hemodialysis patients undergoing recombinant human erythropoietin (rHuEPO) therapy.	Iron	106-110	chromate resistance; sulfate transport	Homo sapiens	45-48
27901468-5	2016	In fh mutants, iron accumulation in the nervous system enhances the synthesis of sphingolipids, which in turn activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2) to trigger neurodegeneration of adult photoreceptors.	Iron	15-19	3-phosphoinositide dependent protein kinase 1	Homo sapiens	120-165
27901468-6	2016	Here, we show that loss of Fxn in the nervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mechanism is evolutionarily conserved.	Iron	79-83	frataxin	Mus musculus	27-30
15352214-7	2004	Mice deficient in transferrin must receive transferrin injections beginning at birth to remain viable, and these mice had increases in all of the myelin components and in the iron content of the myelin.	Iron	175-179	transferrin	Mus musculus	18-29
15352214-8	2004	This finding indicates that the loss of endogenous iron mobility in oligodendrocytes could be overcome by application of exogenous transferrin.	Iron	51-55	transferrin	Mus musculus	131-142
27852236-0	2016	Effects of intravenous iron on fibroblast growth factor 23 (FGF23) in haemodialysis patients: a randomized controlled trial.	Iron	23-27	fibroblast growth factor 23	Homo sapiens	31-58
27852236-0	2016	Effects of intravenous iron on fibroblast growth factor 23 (FGF23) in haemodialysis patients: a randomized controlled trial.	Iron	23-27	fibroblast growth factor 23	Homo sapiens	60-65
15304363-2	2004	Reduction of frataxin has been associated with iron accumulation and sensitivity to iron induced oxidative stress.	Iron	47-51	frataxin	Mus musculus	13-21
27852236-1	2016	BACKGROUND: Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function.	Iron	24-28	fibroblast growth factor 23	Homo sapiens	60-87
15304363-2	2004	Reduction of frataxin has been associated with iron accumulation and sensitivity to iron induced oxidative stress.	Iron	84-88	frataxin	Mus musculus	13-21
27852236-1	2016	BACKGROUND: Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function.	Iron	24-28	fibroblast growth factor 23	Homo sapiens	90-95
27852236-1	2016	BACKGROUND: Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function.	Iron	151-155	fibroblast growth factor 23	Homo sapiens	60-87
27852236-1	2016	BACKGROUND: Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function.	Iron	151-155	fibroblast growth factor 23	Homo sapiens	90-95
15262227-0	2004	hIscA: a protein implicated in the biogenesis of iron-sulfur clusters.	Iron	49-53	iron-sulfur cluster assembly 1	Homo sapiens	0-5
27843711-10	2016	Apoptosis, which was evaluated by Annexin V/propidium iodide staining, Hoechst 33258 staining, and the activation of caspase-3, was detected after exposure to iron.	Iron	159-163	annexin A5	Mus musculus	34-43
15257718-1	2004	The effect of HFE inactivation on iron homeostasis during an acute phase response was investigated in mice.	Iron	34-38	homeostatic iron regulator	Mus musculus	14-17
27843711-10	2016	Apoptosis, which was evaluated by Annexin V/propidium iodide staining, Hoechst 33258 staining, and the activation of caspase-3, was detected after exposure to iron.	Iron	159-163	caspase 3	Mus musculus	117-126
27843711-11	2016	Iron contributed to the permeabilizatio of mitochondria, leading to the release of cytochrome C (cyto C), which, in turn, induced mitochondrial apoptosis in osteoblasts via activation of Caspase-3, up-regulation of Bax, and down-regulation of Bcl-2.	Iron	0-4	caspase 3	Mus musculus	187-196
15239962-0	2004	Effects of iron-chelators on ion-channels and HIF-1alpha in the carotid body.	Iron	11-15	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	46-56
27843711-11	2016	Iron contributed to the permeabilizatio of mitochondria, leading to the release of cytochrome C (cyto C), which, in turn, induced mitochondrial apoptosis in osteoblasts via activation of Caspase-3, up-regulation of Bax, and down-regulation of Bcl-2.	Iron	0-4	BCL2-associated X protein	Mus musculus	215-218
27796299-5	2016	Mutant LCN2 strips iron from transferrin and citrate, and delivers it into the urine.	Iron	19-23	transferrin	Mus musculus	29-40
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Iron	53-57	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	144-148
15133041-9	2004	Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation.	Iron	183-187	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	144-148
15123690-1	2004	Isu, the scaffold for assembly of Fe-S clusters in the yeast mitochondrial matrix, is a substrate protein for the Hsp70 Ssq1 and the J-protein Jac1 in vitro.	Iron	34-38	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	143-147
27796299-7	2016	In each case, the mutants reduce redox activity typical of non-transferrin-bound iron.	Iron	81-85	transferrin	Mus musculus	63-74
27519415-6	2016	Unlike complexes formed by fungal orthologs, human Glrx3-BolA2 interaction required the coordination of Fe-S clusters, whereas Glrx3 homodimer formation did not.	Iron	104-108	bolA family member 2	Homo sapiens	57-62
15254112-3	2004	When Fe(0) was used to treat a munitions-contaminated soil, we observed high rates of destruction for RDX and TNT (98%) but not HMX.	Iron	5-10	radixin	Homo sapiens	102-105
27519415-7	2016	Cellular Glrx3 BolA2 complexes increased 6-8-fold in response to increasing iron, forming a rapidly expandable pool of Fe-S clusters.	Iron	76-80	bolA family member 2	Homo sapiens	15-20
15254112-5	2004	To determine electron acceptor preference, we treated RDX and HMX with Fe(0) in homogeneous solutions and binary mixtures.	Iron	71-76	radixin	Homo sapiens	54-57
27519415-7	2016	Cellular Glrx3 BolA2 complexes increased 6-8-fold in response to increasing iron, forming a rapidly expandable pool of Fe-S clusters.	Iron	119-123	bolA family member 2	Homo sapiens	15-20
27519415-8	2016	Fe-S coordination by Glrx3 BolA2 did not depend on Ciapin1 or Ciao1, proteins that bind Glrx3 and are involved in cytosolic Fe-S cluster assembly and distribution.	Iron	0-4	bolA family member 2	Homo sapiens	27-32
27519415-9	2016	Instead, Glrx3 and BolA2 bound and facilitated Fe-S incorporation into Ciapin1, a [2Fe-2S] protein functioning early in the cytosolic Fe-S assembly pathway.	Iron	47-51	bolA family member 2	Homo sapiens	19-24
27519415-9	2016	Instead, Glrx3 and BolA2 bound and facilitated Fe-S incorporation into Ciapin1, a [2Fe-2S] protein functioning early in the cytosolic Fe-S assembly pathway.	Iron	134-138	bolA family member 2	Homo sapiens	19-24
15709419-3	2004	The purity of the purified Cyt-C was verified by reversed-phase liquid chromatography, UV spectroscopy, and iron content in it.	Iron	108-112	cytochrome c	Sus scrofa	27-32
27741250-5	2016	Interestingly, the mutation in IRA2 only impacted anaerobic xylose consumption and required the loss of ISU1 function, indicating a previously unknown connection between PKA signaling, Fe-S cluster biogenesis, and anaerobiosis.	Iron	185-189	Ras GTPase activating protein IRA2	Saccharomyces cerevisiae S288C	31-35
15192150-1	2004	The antimicrobial peptide hepcidin appears to play a central role in the regulation of iron homeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	26-34
27741250-5	2016	Interestingly, the mutation in IRA2 only impacted anaerobic xylose consumption and required the loss of ISU1 function, indicating a previously unknown connection between PKA signaling, Fe-S cluster biogenesis, and anaerobiosis.	Iron	185-189	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	104-108
15192150-2	2004	In intact animals, iron overload or the injection of lipopolysaccharide (LPS) stimulates transcription of HAMP, the gene that encodes hepcidin.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	134-142
15192150-6	2004	Studies in humans and mice have shown that this iron-dependent pathway requires the presence of Hfe, hemojuvelin, and probably transferrin receptor 2 (tfr-2).	Iron	48-52	homeostatic iron regulator	Mus musculus	96-99
27576776-0	2016	Toll-Like Receptor 4/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage.	Iron	83-87	myeloid differentiation primary response gene 88	Mus musculus	21-26
15192150-6	2004	Studies in humans and mice have shown that this iron-dependent pathway requires the presence of Hfe, hemojuvelin, and probably transferrin receptor 2 (tfr-2).	Iron	48-52	hemojuvelin BMP co-receptor	Mus musculus	101-112
15192150-6	2004	Studies in humans and mice have shown that this iron-dependent pathway requires the presence of Hfe, hemojuvelin, and probably transferrin receptor 2 (tfr-2).	Iron	48-52	transferrin receptor 2	Mus musculus	127-149
15192150-6	2004	Studies in humans and mice have shown that this iron-dependent pathway requires the presence of Hfe, hemojuvelin, and probably transferrin receptor 2 (tfr-2).	Iron	48-52	transferrin receptor 2	Mus musculus	151-156
27576776-0	2016	Toll-Like Receptor 4/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage.	Iron	83-87	hepcidin antimicrobial peptide	Mus musculus	49-57
15165856-7	2004	However, the His81(E7) imidazole group coordinates directly to the heme iron as a sixth axial ligand to form a hexcoordinated heme, like Ngb and rice Hb.	Iron	72-76	neuroglobin	Homo sapiens	137-140
27576776-4	2016	METHODS: Parabiosis and ICH models combined with in vivo and in vitro experiments were used to investigate the roles of hepcidin in brain iron metabolism after ICH.	Iron	138-142	hepcidin antimicrobial peptide	Mus musculus	120-128
27576776-6	2016	The brain iron efflux, oxidative brain injury, and cognition impairment were improved in Hepc-/- ICH mice but aggravated by the human hepcidin-25 peptide in C57BL/6 ICH mice.	Iron	10-14	hepcidin antimicrobial peptide	Mus musculus	89-93
27576776-7	2016	Data obtained in in vitro studies showed that increased hepcidin inhibited the intracellular iron efflux of brain microvascular endothelial cells but was rescued by a hepcidin antagonist, fursultiamine.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	56-64
15182940-7	2004	Methemoglobin (MetHb) formation roughly paralleled iron release.	Iron	51-55	hemoglobin subunit gamma 2	Homo sapiens	0-13
27647917-2	2016	Our data reconcile the apparently discrepant existing dataset, by clarifying the effects of spin (high/low) and valence (ferrous/ferric) states on iron partitioning in the deep mantle.	Iron	147-151	spindlin 1	Homo sapiens	92-96
15158327-7	2004	Both hepatic HAMP and HAMP2 mRNA levels were elevated by iron overload, but treatment with lipopolysaccharide increased only HAMP mRNA.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	13-17
15158327-7	2004	Both hepatic HAMP and HAMP2 mRNA levels were elevated by iron overload, but treatment with lipopolysaccharide increased only HAMP mRNA.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	22-26
15173932-0	2004	Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability.	Iron	59-63	homeostatic iron regulator	Mus musculus	9-12
27403535-10	2016	In conclusion, GlyT1 inhibition in rats induced a steady-state microcytic hypochromic regenerative anemia and a species-specific accumulation of uncommitted mitochondrial iron in reticulocytes.	Iron	171-175	solute carrier family 6 member 9	Rattus norvegicus	15-20
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	49-53	homeostatic iron regulator	Mus musculus	0-3
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	49-53	transferrin	Mus musculus	31-42
15217087-3	2004	Heme in ICH induces heme oxygenase-1 (HO-1), and the action of this enzyme on heme yields ferrous iron, biliverdin, and carbon monoxide.	Iron	90-102	heme oxygenase 1	Oryctolagus cuniculus	20-36
15217087-3	2004	Heme in ICH induces heme oxygenase-1 (HO-1), and the action of this enzyme on heme yields ferrous iron, biliverdin, and carbon monoxide.	Iron	90-102	heme oxygenase 1	Oryctolagus cuniculus	38-42
27403769-2	2016	The goals of this study are to determine the reference intervals for CHr in healthy children, and their relation with iron parameters, erythropoiesis, and individual conditions.	Iron	118-122	chromate resistance; sulfate transport	Homo sapiens	69-72
15020597-1	2004	Neuroglobin, recently discovered in the brain and in the retina of vertebrates, belongs to the class of hexacoordinate globins, in which the distal histidine coordinates the iron center in both the Fe(II) and Fe(III) forms.	Iron	174-178	neuroglobin	Homo sapiens	0-11
15020597-1	2004	Neuroglobin, recently discovered in the brain and in the retina of vertebrates, belongs to the class of hexacoordinate globins, in which the distal histidine coordinates the iron center in both the Fe(II) and Fe(III) forms.	Iron	198-200	neuroglobin	Homo sapiens	0-11
27688041-0	2016	Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.	Iron	38-42	nuclear receptor subfamily 0, group B, member 2	Mus musculus	24-27
18950124-1	2004	The adsorption of gases N2, H2, O2, and NH3 that play a role in ammonia synthesis have been studied on the Fe(111) crystal surface by Sum Frequency Generation (SFG) vibrational spectroscopy using an integrated ultrahigh vacuum/high-pressure system.	Iron	107-109	relaxin 2	Homo sapiens	18-43
27688041-0	2016	Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.	Iron	38-42	hepcidin antimicrobial peptide	Mus musculus	90-98
14751922-0	2004	Effect of hepcidin on intestinal iron absorption in mice.	Iron	33-37	hepcidin antimicrobial peptide	Mus musculus	10-18
27688041-2	2016	Here, we show that SHP acts as an intrinsic negative regulator of iron homeostasis.	Iron	66-70	nuclear receptor subfamily 0, group B, member 2	Mus musculus	19-22
14751922-1	2004	The effect of the putative iron regulatory peptide hepcidin on iron absorption was investigated in mice.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	51-59
14751922-1	2004	The effect of the putative iron regulatory peptide hepcidin on iron absorption was investigated in mice.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	51-59
27688041-3	2016	SHP-deficient mice maintained on a high-iron diet showed increased serum hepcidin levels, decreased expression of the iron exporter ferroportin as well as iron accumulation compared to WT mice.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	73-81
14751922-2	2004	Hepcidin peptide was synthesized and injected into mice for up to 3 days, and in vivo iron absorption was measured with tied-off segments of duodenum.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	0-8
14751922-4	2004	Hepcidin significantly reduced mucosal iron uptake and transfer to the carcass at doses of at least 10 microg/mouse per day, the reduction in transfer to the carcass being proportional to the reduction in iron uptake.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	0-8
27688041-7	2016	Finally, overexpression of SHP and metformin treatment of BMP6 stimulated mice substantially restored hepcidin expression and serum iron to baseline levels.	Iron	132-136	nuclear receptor subfamily 0, group B, member 2	Mus musculus	27-30
27688041-8	2016	These results reveal a previously unrecognized role for SHP in the transcriptional control of iron homeostasis.	Iron	94-98	nuclear receptor subfamily 0, group B, member 2	Mus musculus	56-59
27619094-3	2016	In this paper, one of the impurities namely Fe is being considered as it posed a challenge to the separation due to its co-extraction with TBP along with uranium.	Iron	44-46	TATA-box binding protein	Homo sapiens	139-142
15176725-8	2004	Frataxin is a highly conserved mitochondrial protein that plays a critical role in iron homeostasis.	Iron	83-87	frataxin	Mus musculus	0-8
15176725-9	2004	Respiratory deficits, abnormal cellular iron distribution and increased oxidative damage are associated with frataxin defects in yeast and mouse models of FRDA.	Iron	40-44	frataxin	Mus musculus	109-117
15176725-10	2004	The mechanism by which frataxin regulates iron metabolism is unknown.	Iron	42-46	frataxin	Mus musculus	23-31
27619094-7	2016	This has been the first time application of pure TBP for selective removal of iron from uranium samples.	Iron	78-82	TATA-box binding protein	Homo sapiens	49-52
15176725-16	2004	In conclusion, by coupling iron oxidation with stepwise assembly, frataxin can successively function as an iron chaperon or an iron store.	Iron	27-31	frataxin	Mus musculus	66-74
27729871-1	2016	Lipocalin 2 (LCN2) is a secreted protein that belongs to the Lipocalins, a group of transporters of small lipophilic molecules such as steroids, lipopolysaccharides, iron, and fatty acids in circulation.	Iron	166-170	lipocalin 2	Homo sapiens	0-11
15176725-16	2004	In conclusion, by coupling iron oxidation with stepwise assembly, frataxin can successively function as an iron chaperon or an iron store.	Iron	107-111	frataxin	Mus musculus	66-74
15176725-16	2004	In conclusion, by coupling iron oxidation with stepwise assembly, frataxin can successively function as an iron chaperon or an iron store.	Iron	107-111	frataxin	Mus musculus	66-74
27729871-1	2016	Lipocalin 2 (LCN2) is a secreted protein that belongs to the Lipocalins, a group of transporters of small lipophilic molecules such as steroids, lipopolysaccharides, iron, and fatty acids in circulation.	Iron	166-170	lipocalin 2	Homo sapiens	13-17
15124225-1	2004	Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis.	Iron	78-82	transferrin receptor 2	Mus musculus	0-22
15124225-1	2004	Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis.	Iron	78-82	transferrin receptor 2	Mus musculus	24-28
27621439-5	2016	Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the NAF-1 cluster, NAF-1(H114C), in xenograft breast cancer tumors results in a dramatic decrease in tumor size that is accompanied by enhanced mitochondrial iron and reactive oxygen accumulation and reduced cellular tolerance to oxidative stress.	Iron	248-252	CDGSH iron sulfur domain 2	Homo sapiens	32-37
15124225-5	2004	The development of these mice will provide new models for type 3 hemochromatosis and assist in determining the role of TfR2 in iron metabolism.	Iron	127-131	transferrin receptor 2	Mus musculus	119-123
15082582-5	2004	Duodenal expression of the iron transport molecules DMT1, Dcytb, and Ireg1 increased during pregnancy, and this corresponded with a reduction in hepcidin, HFE, and transferrin receptor 2 expression in the liver.	Iron	27-31	RoBo-1	Rattus norvegicus	52-56
15082582-5	2004	Duodenal expression of the iron transport molecules DMT1, Dcytb, and Ireg1 increased during pregnancy, and this corresponded with a reduction in hepcidin, HFE, and transferrin receptor 2 expression in the liver.	Iron	27-31	transferrin receptor 2	Rattus norvegicus	164-186
27621439-5	2016	Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the NAF-1 cluster, NAF-1(H114C), in xenograft breast cancer tumors results in a dramatic decrease in tumor size that is accompanied by enhanced mitochondrial iron and reactive oxygen accumulation and reduced cellular tolerance to oxidative stress.	Iron	248-252	CDGSH iron sulfur domain 2	Homo sapiens	94-99
15225803-3	2004	Heat shock protein-32 is a well-established marker of the cerebral oxidative stress response and contributes to neuroprotection by metabolising cytotoxic free heme to carbon monoxide, iron and biliverdin.	Iron	184-188	heme oxygenase 1	Rattus norvegicus	0-21
27621439-5	2016	Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the NAF-1 cluster, NAF-1(H114C), in xenograft breast cancer tumors results in a dramatic decrease in tumor size that is accompanied by enhanced mitochondrial iron and reactive oxygen accumulation and reduced cellular tolerance to oxidative stress.	Iron	248-252	CDGSH iron sulfur domain 2	Homo sapiens	94-99
15086960-3	2004	The amino acid sequence of CAO predicts mononuclear iron and Rieske iron-sulfur centers in the protein.	Iron	52-56	uncharacterized protein	Chlamydomonas reinhardtii	27-30
27621439-6	2016	Furthermore, treating breast cancer cells with pioglitazone that stabilizes the 3Cys-1His cluster of NAF-1 results in a similar effect on mitochondrial iron and reactive oxygen species accumulation.	Iron	152-156	CDGSH iron sulfur domain 2	Homo sapiens	101-106
15086960-3	2004	The amino acid sequence of CAO predicts mononuclear iron and Rieske iron-sulfur centers in the protein.	Iron	68-72	uncharacterized protein	Chlamydomonas reinhardtii	27-30
27546061-4	2016	On the basis of the split Soret ultraviolet-visible (UV-vis) spectrum of ferric DGCR8, bis-thiolate sulfur (cysteinate, Cys(-)) heme iron coordination of DGCR8 heme iron was proposed.	Iron	133-137	DGCR8 microprocessor complex subunit	Homo sapiens	80-85
15086960-7	2004	The electron paramagnetic resonance spectrum of CAO included a resonance at g = 4.3, assigned to the predicted mononuclear iron center.	Iron	123-127	uncharacterized protein	Chlamydomonas reinhardtii	48-51
27546061-4	2016	On the basis of the split Soret ultraviolet-visible (UV-vis) spectrum of ferric DGCR8, bis-thiolate sulfur (cysteinate, Cys(-)) heme iron coordination of DGCR8 heme iron was proposed.	Iron	133-137	DGCR8 microprocessor complex subunit	Homo sapiens	154-159
27546061-4	2016	On the basis of the split Soret ultraviolet-visible (UV-vis) spectrum of ferric DGCR8, bis-thiolate sulfur (cysteinate, Cys(-)) heme iron coordination of DGCR8 heme iron was proposed.	Iron	165-169	DGCR8 microprocessor complex subunit	Homo sapiens	80-85
15060275-8	2004	Furthermore, YOL101c is induced by deletion of the Aft1p iron-responsive transcription factor.	Iron	57-61	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	51-56
27546061-4	2016	On the basis of the split Soret ultraviolet-visible (UV-vis) spectrum of ferric DGCR8, bis-thiolate sulfur (cysteinate, Cys(-)) heme iron coordination of DGCR8 heme iron was proposed.	Iron	165-169	DGCR8 microprocessor complex subunit	Homo sapiens	154-159
14604961-1	2004	Hepcidin is a 25-amino acid peptide involved in iron homeostasis in mice and humans.	Iron	48-52	hepcidin antimicrobial peptide	Mus musculus	0-8
27546061-6	2016	These studies indicate DGCR8 bis-Cys heme iron ligation, with conversion from bis-thiolate (Cys(-)/Cys(-)) axial coordination in ferric DGCR8 to bis-thiol (CysH/CysH) coordination in ferrous DGCR8.	Iron	42-46	DGCR8 microprocessor complex subunit	Homo sapiens	23-28
27532889-0	2016	Computational Insights into Five- versus Six-Coordinate Iron Center in Ferrous Soybean Lipoxygenase.	Iron	56-60	linoleate 9S-lipoxygenase-4	Glycine max	87-99
14656876-4	2004	In mice, deficiency of either HFE (Hfe(-/-)) or hepcidin (Usf2(-/-)) is associated with the same pattern of iron overload observed in patients with HH.	Iron	108-112	homeostatic iron regulator	Mus musculus	35-44
14656876-4	2004	In mice, deficiency of either HFE (Hfe(-/-)) or hepcidin (Usf2(-/-)) is associated with the same pattern of iron overload observed in patients with HH.	Iron	108-112	hepcidin antimicrobial peptide	Mus musculus	48-56
14656876-6	2004	Our results showed that, indeed, liver iron accumulation was greater in the Hfe(-/-)Usf2(+/-) mice than in mice lacking Hfe alone.	Iron	39-43	homeostatic iron regulator	Mus musculus	76-79
27714044-7	2016	This led us to postulate that Atp7a may influence intestinal iron flux.	Iron	61-65	ATPase copper transporting alpha	Homo sapiens	30-35
27714044-12	2016	Expression of Dmt1 (the iron importer), Dcytb (an apical membrane ferrireductase) and Fpn1 (the iron exporter) was decreased in Atp7a knockdown (KD) cells.	Iron	24-28	ATPase copper transporting alpha	Homo sapiens	128-133
27714044-16	2016	In summary, in these reductionist models of the mammalian intestinal epithelium, Atp7a KD altered expression of iron transporters and impaired iron flux.	Iron	112-116	ATPase copper transporting alpha	Homo sapiens	81-86
27576789-7	2016	Orally fed iron saturated bLf-Dox inhibited tumour development, prolonged survival, reduced Dox induced general toxicity, cardiotoxicity, neurotoxicity in TRAMP mice and upregulated serum levels of anti-cancer molecules TNF-alpha, IFN-gamma, CCL4 and CCL17.	Iron	11-15	chemokine (C-C motif) ligand 4	Mus musculus	242-246
15064157-2	2004	The hypothesis is that subjects with the ALAD 1-1 genotype are more susceptible to lead exposure with impaired hematologic synthesis and therefore that iron nutrition is more important in those with the ALAD 1-1 genotype.	Iron	152-156	aminolevulinate dehydratase	Homo sapiens	203-207
15030976-5	2004	The iron-induced cell injury was oxygen-dependent, and although it was not inhibitable by extracellular catalase, it was strongly inhibited by the novel membrane-permeable catalase mimic TAA-1/Fe.	Iron	4-8	PVR cell adhesion molecule	Rattus norvegicus	187-192
26758041-3	2016	Using double immunofluorescence and sequential iron and immunohistochemistry staining, we showed that marrow iron colocalizes with HO1 and H-ferritin to CD163 + macrophages.	Iron	109-113	CD163 molecule	Homo sapiens	153-158
26758041-5	2016	Among MDS patients only, CD163 + macrophage density and HO1 and H-ferritin expression by CD163 + macrophages increased in tandem with marrow iron.	Iron	141-145	CD163 molecule	Homo sapiens	25-30
27188291-0	2016	Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.	Iron	42-46	cytochrome b5 reductase 4	Mus musculus	8-14
15032831-10	2004	The results are discussed in terms of different binding properties of the heme iron to the protonated or unprotonated histidine ligand in the high-potential and low-potential forms of cytochrome b(559), respectively.	Iron	79-83	mitochondrially encoded cytochrome b	Homo sapiens	184-196
14722110-6	2004	Many Aft1-dependent genes involved in iron utilization that are up-regulated in a frataxin mutant were also up-regulated in the absence of Grx5.	Iron	38-42	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	5-9
14722110-7	2004	BIO5 is another Aft1-dependent gene induced both upon iron deprivation and in Deltagrx5 cells; this links iron and biotin metabolism.	Iron	54-58	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	16-20
27188291-3	2016	We previously reported that global gene ablation of NCB5OR resulted in early-onset diabetes and altered iron homeostasis in mice.	Iron	104-108	cytochrome b5 reductase 4	Mus musculus	52-58
27188291-12	2016	Our findings suggest an essential role for NCB5OR in maintaining both iron homeostasis and the proper functioning of various locomotor pathways in the mouse cerebellum and midbrain.	Iron	70-74	cytochrome b5 reductase 4	Mus musculus	43-49
26891670-6	2016	Multi-target ligands designed to combat the elevated activity of MAO B in Alzheimer"s and Parkinson"s Diseases incorporate MAO inhibition (usually irreversible) as well as iron chelation, antioxidant or neuroprotective properties.	Iron	172-176	monoamine oxidase B	Homo sapiens	65-70
15004242-1	2004	The Escherichia coli AlkB protein was recently found to repair cytotoxic DNA lesions 1-methyladenine and 3-methylcytosine by using a novel iron-catalyzed oxidative demethylation mechanism.	Iron	139-143	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	21-25
15105256-1	2004	In mammals, iron regulatory proteins 1 and 2 (IRP1 and IRP2) posttranscriptionally regulate expression of several iron metabolism proteins including ferritin and transferrin receptor.	Iron	12-16	aconitase 1	Mus musculus	46-50
15105256-1	2004	In mammals, iron regulatory proteins 1 and 2 (IRP1 and IRP2) posttranscriptionally regulate expression of several iron metabolism proteins including ferritin and transferrin receptor.	Iron	12-16	iron responsive element binding protein 2	Mus musculus	55-59
15105256-1	2004	In mammals, iron regulatory proteins 1 and 2 (IRP1 and IRP2) posttranscriptionally regulate expression of several iron metabolism proteins including ferritin and transferrin receptor.	Iron	12-16	transferrin	Mus musculus	162-173
15003819-1	2004	Hepcidin (HEPC) plays a key role in iron homeostasis and an abnormally low level of hepcidin mRNA has been reported in HFE-1 genetic hemochromatosis.	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	0-8
15003819-1	2004	Hepcidin (HEPC) plays a key role in iron homeostasis and an abnormally low level of hepcidin mRNA has been reported in HFE-1 genetic hemochromatosis.	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	10-14
27493939-13	2016	Dietary iron also decreased brain iron content and FtH protein expression in a regionally specific manner.	Iron	8-12	ferritin heavy polypeptide 1	Mus musculus	51-54
14668481-1	2004	The budding yeast Saccharomyces cerevisiae responds to depletion of iron in the environment by activating Aft1p, the major iron-dependent transcription factor, and by transcribing systems involved in the uptake of iron.	Iron	68-72	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	106-111
14668481-1	2004	The budding yeast Saccharomyces cerevisiae responds to depletion of iron in the environment by activating Aft1p, the major iron-dependent transcription factor, and by transcribing systems involved in the uptake of iron.	Iron	83-87	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	106-111
14668481-1	2004	The budding yeast Saccharomyces cerevisiae responds to depletion of iron in the environment by activating Aft1p, the major iron-dependent transcription factor, and by transcribing systems involved in the uptake of iron.	Iron	83-87	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	106-111
14668481-2	2004	Here, we have studied the transcriptional response to iron deprivation and have identified new Aft1p target genes.	Iron	54-58	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	95-100
27432047-3	2016	Here, we provide evidence of two-terminal electrical spin injection and detection in Fe/GaAs/Fe vertical spin-valves (SVs) with the GaAs layer of 50 nanometers thick and top and bottom Fe electrodes deposited by molecular beam epitaxy.	Iron	85-87	spindlin 1	Homo sapiens	53-57
14648120-9	2004	This is consistent with recent findings with Arabidopsis IRT1 knockout mutants that strongly suggest that this transporter plays a key role in root Fe uptake and nutrition.	Iron	148-150	iron-regulated transporter 1	Arabidopsis thaliana	57-61
15024413-2	2004	Phenotypic analyses of animals with spontaneous mutations in DMT1 indicate that it functions at two distinct sites, transporting dietary iron across the apical membrane of intestinal absorptive cells, and transporting endosomal iron released from transferrin into the cytoplasm of erythroid precursors.	Iron	228-232	transferrin	Mus musculus	247-258
27432047-3	2016	Here, we provide evidence of two-terminal electrical spin injection and detection in Fe/GaAs/Fe vertical spin-valves (SVs) with the GaAs layer of 50 nanometers thick and top and bottom Fe electrodes deposited by molecular beam epitaxy.	Iron	85-87	spindlin 1	Homo sapiens	105-109
27432047-4	2016	The spin-valve effect, which corresponds to the individual switching of the top and bottom Fe layers, is bias dependent and observed up to 20 K. We propose that the strongly bias- and temperature-dependent MR is associated with spin transport at the interfacial Fe/GaAs Schottky contacts and in the GaAs membranes, where balance between the barrier profiles as well as the dwell time to spin lifetime ratio are crucial factors for determining the device operations.	Iron	91-93	spindlin 1	Homo sapiens	4-8
27432047-4	2016	The spin-valve effect, which corresponds to the individual switching of the top and bottom Fe layers, is bias dependent and observed up to 20 K. We propose that the strongly bias- and temperature-dependent MR is associated with spin transport at the interfacial Fe/GaAs Schottky contacts and in the GaAs membranes, where balance between the barrier profiles as well as the dwell time to spin lifetime ratio are crucial factors for determining the device operations.	Iron	91-93	spindlin 1	Homo sapiens	228-232
14637339-8	2004	Results also confirmed extensive RDX mineralization in bioaugmented (but not in abiotic) Fe0 systems, and support the notion that permeable reactive iron barriers performance might be enhanced by the participation of some microorganisms.	Iron	149-153	radixin	Homo sapiens	33-36
27432047-4	2016	The spin-valve effect, which corresponds to the individual switching of the top and bottom Fe layers, is bias dependent and observed up to 20 K. We propose that the strongly bias- and temperature-dependent MR is associated with spin transport at the interfacial Fe/GaAs Schottky contacts and in the GaAs membranes, where balance between the barrier profiles as well as the dwell time to spin lifetime ratio are crucial factors for determining the device operations.	Iron	91-93	spindlin 1	Homo sapiens	228-232
27385438-6	2016	LCN2 reduced osteoblast viability in the presence of iron and enhanced the activity of MMP-9 released by osteoblasts.	Iron	53-57	lipocalin 2	Homo sapiens	0-4
14643898-0	2004	Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells.	Iron	116-120	MIR7-3 host gene	Homo sapiens	147-152
27129231-1	2016	The hepatic hormone hepcidin is the master regulator of systemic iron homeostasis.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	20-28
14684575-16	2004	CONCLUSIONS: In addition to release, ferroportin functions in the uptake of iron at the apical membrane, possibly by modulating the activity of DMT1.	Iron	76-80	RoBo-1	Rattus norvegicus	144-148
15060899-0	2004	The use of iron-fortified wheat flour to reduce anemia among the estate population in Sri Lanka.	Iron	11-15	sorcin	Homo sapiens	86-89
27129231-3	2016	Bone morphogenetic protein 6 (BMP6) contributes to the iron-dependent control of hepcidin.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	81-89
27129231-10	2016	TGF-beta1 mRNA levels are increased in mouse models of iron overload, indicating that TGF-beta1 may contribute to hepcidin synthesis under these conditions.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	114-122
27143686-5	2016	Spin-exchange interactions were investigated for a Fe-Co metallic glass system of composition [(Co1-x Fe x )0.75B0.2Si0.05]96Cr4.	Iron	51-53	spindlin 1	Homo sapiens	0-4
14688618-10	2004	In contrast, in Belgrade rats, whose brain is iron deficient, the expression of both divalent metal transporter 1 and transferrin receptor was increased compared with control in almost all brain regions examined, but not transferrin or ferritin.	Iron	46-50	RoBo-1	Rattus norvegicus	85-113
27101151-4	2016	The data show that its electronic structure is best described as a high-spin iron(IV) center bound to a triplet NO(-) ligand with a very covalent iron-NO bond.	Iron	77-81	spindlin 1	Homo sapiens	72-76
15151266-3	2004	The reticulocyte hemoglobin content (CHr) has recently been proposed as a useful tool in iron status assessment.	Iron	89-93	chromate resistance; sulfate transport	Homo sapiens	37-40
15151266-5	2004	This study aimed to assess the relationship between CHr with other parameters of iron status as well as with C-reactive protein (CRP).	Iron	81-85	chromate resistance; sulfate transport	Homo sapiens	52-55
14770366-2	2004	The classical view of iron metabolism has been challenged over the past ten years by the discovery of several new proteins, mostly Fe (II) iron transporters, enzymes with ferro-oxydase (hephaestin or ceruloplasmin) or ferri-reductase (Dcytb) activity or regulatory proteins like HFE and hepcidin.	Iron	22-26	cytochrome b reductase 1	Homo sapiens	235-240
14770366-4	2004	Intestinal iron absorption by mature duodenal enterocytes requires Fe (III) iron reduction by Dcytb and Fe (II) iron transport through apical membranes by the iron transporter Nramp2/DMT1.	Iron	11-15	cytochrome b reductase 1	Homo sapiens	94-99
27101151-4	2016	The data show that its electronic structure is best described as a high-spin iron(IV) center bound to a triplet NO(-) ligand with a very covalent iron-NO bond.	Iron	146-150	spindlin 1	Homo sapiens	72-76
27101151-5	2016	This finding demonstrates that this high-spin iron nitrosyl compound undergoes iron-centered redox chemistry, leading to fundamentally different properties than corresponding low-spin compounds, which undergo NO-centered redox transformations.	Iron	46-50	spindlin 1	Homo sapiens	41-45
27101151-5	2016	This finding demonstrates that this high-spin iron nitrosyl compound undergoes iron-centered redox chemistry, leading to fundamentally different properties than corresponding low-spin compounds, which undergo NO-centered redox transformations.	Iron	46-50	spindlin 1	Homo sapiens	179-183
14673166-3	2004	We have reported that treatment of RAW 264.7 cells with NO caused a decrease in levels of iron regulatory protein 2 (IRP2), which binds to iron-responsive elements present in untranslated regions of mRNAs for several proteins involved in iron metabolism.	Iron	90-94	iron responsive element binding protein 2	Mus musculus	117-121
14673166-3	2004	We have reported that treatment of RAW 264.7 cells with NO caused a decrease in levels of iron regulatory protein 2 (IRP2), which binds to iron-responsive elements present in untranslated regions of mRNAs for several proteins involved in iron metabolism.	Iron	139-143	iron responsive element binding protein 2	Mus musculus	90-115
27101151-5	2016	This finding demonstrates that this high-spin iron nitrosyl compound undergoes iron-centered redox chemistry, leading to fundamentally different properties than corresponding low-spin compounds, which undergo NO-centered redox transformations.	Iron	79-83	spindlin 1	Homo sapiens	41-45
14673166-3	2004	We have reported that treatment of RAW 264.7 cells with NO caused a decrease in levels of iron regulatory protein 2 (IRP2), which binds to iron-responsive elements present in untranslated regions of mRNAs for several proteins involved in iron metabolism.	Iron	139-143	iron responsive element binding protein 2	Mus musculus	117-121
27101151-5	2016	This finding demonstrates that this high-spin iron nitrosyl compound undergoes iron-centered redox chemistry, leading to fundamentally different properties than corresponding low-spin compounds, which undergo NO-centered redox transformations.	Iron	79-83	spindlin 1	Homo sapiens	179-183
27219324-13	2016	Furthermore, we demonstrated the recyclable use of the iron catalyst and obtained the desired Nazarov/Michael reaction products in good yields for five repetitions of the reactions without any addition of the catalyst using an ionic liquid, [bmim][NTf2 ], as the solvent.	Iron	55-59	nuclear transport factor 2	Homo sapiens	248-252
15061081-3	2004	Recent work with LMCOs from bacteria, yeast and mammals has shown that metal oxidase activities in these enzymes can be important for their primary physiological functions, With respect to ferroxidase activity in certain plant LMCOs, it is proposed that the high levels of LMCO expression in plant vascular tissues may reflect the need for high-efficiency iron uptake pumps in tissues that undergo lignification during normal development.	Iron	356-360	ferroxidase	Saccharomyces cerevisiae S288C	189-200
27026139-2	2016	Although high expression of the mitochondrial iron importer, mitoferrin, appears to be an underlying common feature, it is unclear what drives high mitoferrin expression and what other proteins are involved in trapping excess toxic iron in the mitochondrial matrix.	Iron	46-50	solute carrier family 25 member 37	Homo sapiens	61-71
14523005-8	2003	Supporting this is that the induction of an Aft1p target gene, FTR1, in response to iron starvation was greatly reduced in pse1-1 cells.	Iron	84-88	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	44-49
14523005-8	2003	Supporting this is that the induction of an Aft1p target gene, FTR1, in response to iron starvation was greatly reduced in pse1-1 cells.	Iron	84-88	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	63-67
14523005-9	2003	Furthermore, we demonstrated that the nuclear localization of a mutant Aft1 protein that contains an NLS derived from SV40 was regulated by iron status regardless of whether Pse1p could interact with Aft1p.	Iron	140-144	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	71-75
27016873-1	2016	Plant heme oxygenase (HO) catalyzes the oxygenation of heme to biliverdin, carbon monoxide, and free iron, and is regarded as a stress-responsive protein.	Iron	101-105	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	6-20
14668284-10	2003	By day 20, DMT1 and FPN1 expression and iron absorption had decreased significantly with iron supplementation.	Iron	89-93	RoBo-1	Rattus norvegicus	11-15
14675444-10	2003	Sequences homologous to IDE1 were also found in many other Fe-deficiency-inducible promoters, including: nicotianamine aminotransferase (HvNAAT)-A, HvNAAT-B, nicotianamine synthase (HvNAS1), HvIDS3, OsNAS1, OsNAS2, OsIRT1, AtIRT1, and AtFRO2, suggesting the conservation of cis-acting elements in various genes and species.	Iron	59-61	iron-regulated transporter 1	Arabidopsis thaliana	223-229
26755707-1	2016	Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	0-8
26755707-1	2016	Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts.	Iron	138-142	hepcidin antimicrobial peptide	Mus musculus	0-8
26941001-0	2016	Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: THE SUB-COMPLEX FORMED BY THE IRON DONOR, Yfh1 PROTEIN, AND THE SCAFFOLD, Isu1 PROTEIN.	Iron	40-44	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	154-158
14623077-14	2003	Further studies showed that PFKFB-1 and PFKFB-2 were highly responsive to hypoxia mimics such as transition metals, iron chelators and inhibitors of HIF hydroxylases, suggesting that the hypoxia responsiveness of these genes is also regulated by HIF proteins.	Iron	116-120	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Mus musculus	40-47
14607516-0	2003	Downregulation of p38 kinase pathway by cAMP response element-binding protein protects HL-60 cells from iron chelator-induced apoptosis.	Iron	104-108	cAMP responsive element binding protein 1	Homo sapiens	40-77
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Iron	77-81	cAMP responsive element binding protein 1	Homo sapiens	14-51
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Iron	77-81	cAMP responsive element binding protein 1	Homo sapiens	53-57
14607516-2	2003	We found that cAMP response element-binding protein (CREB) is cleaved during iron chelator deferoxamine (DFO)-induced apoptosis, and that the cleavage is largely prevented by the cell-permeable analog of cAMP, dibutyryl-cAMP (dbcAMP), a known CREB activator.	Iron	77-81	cAMP responsive element binding protein 1	Homo sapiens	243-247
14607516-4	2003	These results led us to investigate whether CREB activation is functionally connected with the MAPK family members because we previously demonstrated that p38 kinase is involved in iron chelator-induced apoptosis of HL-60 cells.	Iron	181-185	cAMP responsive element binding protein 1	Homo sapiens	44-48
14607516-8	2003	Collectively, these results demonstrate that cAMP-dependent CREB activation plays an important role in protecting HL-60 cells from iron chelator-induced apoptosis, presumably through downregulation of p38 kinase.	Iron	131-135	cAMP responsive element binding protein 1	Homo sapiens	60-64
26941001-6	2016	In each center, conserved amino acids known to be involved in sulfur and iron donation by Nfs1 and Yfh1, respectively, are in close proximity to the Fe-S cluster-coordinating residues of Isu1.	Iron	73-77	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	187-191
26941001-6	2016	In each center, conserved amino acids known to be involved in sulfur and iron donation by Nfs1 and Yfh1, respectively, are in close proximity to the Fe-S cluster-coordinating residues of Isu1.	Iron	149-153	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	187-191
26941001-7	2016	We suggest that this architecture is suitable to ensure concerted and protected transfer of potentially toxic iron and sulfur atoms to Isu1 during Fe-S cluster assembly.	Iron	110-114	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	135-139
26941001-7	2016	We suggest that this architecture is suitable to ensure concerted and protected transfer of potentially toxic iron and sulfur atoms to Isu1 during Fe-S cluster assembly.	Iron	147-149	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	135-139
12920120-6	2003	Homolytic cleavage of peroxynitrite within the heme iron allows the formation of ferrylhemoglobin in approximately 10% yields, which can decay to methemoglobin at the expense of reducing equivalents of the globin moiety.	Iron	52-56	hemoglobin subunit gamma 2	Homo sapiens	146-159
27074728-3	2016	The transition to the high-spin state is accompanied by an increase in Fe-N bond lengths and a concomitant contraction of intraligand N-N bonds.	Iron	71-75	spindlin 1	Homo sapiens	27-31
27200068-0	2016	Common Bean: A Legume Model on the Rise for Unraveling Responses and Adaptations to Iron, Zinc, and Phosphate Deficiencies.	Iron	84-88	brain expressed associated with NEDD4 1	Homo sapiens	7-11
26969708-5	2016	Soybean ferritin protected yeast cells that lacked the Ccc1 vacuolar iron detoxification transporter from toxic iron levels by reducing cellular oxidation, thus allowing growth at high iron concentrations.	Iron	69-73	Ccc1p	Saccharomyces cerevisiae S288C	55-59
26969708-5	2016	Soybean ferritin protected yeast cells that lacked the Ccc1 vacuolar iron detoxification transporter from toxic iron levels by reducing cellular oxidation, thus allowing growth at high iron concentrations.	Iron	112-116	Ccc1p	Saccharomyces cerevisiae S288C	55-59
26779615-9	2016	Finally, increasing the serum levels of hepcidin or transferrin alleviates anemia and dyserythropoiesis by diminishing iron uptake by erythroblasts in mouse models.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	40-48
27091216-9	2016	It is therefore tempting to postulate that the main pathophysiological pathway leading to these events may involve the pleiotropic master hormone hepcidin (synergized by fibroblast growth factor 23), which regulates iron metabolism.	Iron	216-220	fibroblast growth factor 23	Homo sapiens	170-197
26993237-0	2016	CIPK23 is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity.	Iron	22-26	CBL-interacting protein kinase 23	Arabidopsis thaliana	0-6
26993237-4	2016	Here, we demonstrated that the protein kinase CIPK23 was involved in iron acquisition.	Iron	69-73	CBL-interacting protein kinase 23	Arabidopsis thaliana	46-52
26993237-5	2016	Lesion of CIPK23 rendered Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by down-regulating ferric chelate reductase activity.	Iron	64-68	CBL-interacting protein kinase 23	Arabidopsis thaliana	10-16
26993237-5	2016	Lesion of CIPK23 rendered Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by down-regulating ferric chelate reductase activity.	Iron	142-146	CBL-interacting protein kinase 23	Arabidopsis thaliana	10-16
26993237-7	2016	These novel findings highlight the involvement of calcium-dependent CBL-CIPK23 complexes in the regulation of iron acquisition.	Iron	110-114	CBL-interacting protein kinase 23	Arabidopsis thaliana	72-78
27136534-4	2016	Absorption spectra of AHbs distal histidine mutants showed that AHb1 mutant (H69L) is a stable pentacoordinate high-spin species in both ferrous and ferric states, whereas heme iron in AHb2 mutant (H66L) is hexacoordinated low-spin with Lys69 as the sixth ligand.	Iron	177-181	hemoglobin 1	Arabidopsis thaliana	64-68
27023474-5	2016	The functional mechanism of sulfide in the reaction was identified as in the potential region around -1.071 V (vs Hg/HgO), the outside layer of Fe2O3 was reduced to amorphous FeS, which has good electrical conductivity and enlarges the electrochemical reaction interface.	Iron	175-178	homogentisate 1,2-dioxygenase	Homo sapiens	117-120
27023474-7	2016	In the potential region around -1.15 V (vs Hg/HgO), amorphous FeS ages to FeS (pyrrhotite), FeS2 (marcasite), and FeS0.9 (mackinawite), which have high electrical conductivity.	Iron	62-65	homogentisate 1,2-dioxygenase	Homo sapiens	46-49
27152812-4	2016	Using spin pumping from an yttrium iron garnet ferrimagnetic insulator and ionic liquid top gate, we determined that the inverse spin Hall effect is the dominant spin-charge conversion mechanism in single-layer graphene.	Iron	35-39	spindlin 1	Homo sapiens	6-10
27152812-4	2016	Using spin pumping from an yttrium iron garnet ferrimagnetic insulator and ionic liquid top gate, we determined that the inverse spin Hall effect is the dominant spin-charge conversion mechanism in single-layer graphene.	Iron	35-39	spindlin 1	Homo sapiens	129-133
27152812-4	2016	Using spin pumping from an yttrium iron garnet ferrimagnetic insulator and ionic liquid top gate, we determined that the inverse spin Hall effect is the dominant spin-charge conversion mechanism in single-layer graphene.	Iron	35-39	spindlin 1	Homo sapiens	129-133
27042863-3	2016	Most of the reported iron complexes undergo spin crossover at temperatures near or above room temperature in solution and in the solid state.	Iron	21-25	spindlin 1	Homo sapiens	44-48
27042863-4	2016	The change in spin state coincides with a significant change in the degree of pi-bonding between Fe and the bound N atom of the phosphiniminato ligand.	Iron	97-99	spindlin 1	Homo sapiens	14-18
27313332-5	2016	This IGF-1R targeted theranostic nanoparticle delivery system has an iron core for non-invasive MR imaging, amphiphilic polymer coating to ensure the biocompatibility as well as for drug loading and conjugation of recombinant human IGF-1 as targeting molecules.	Iron	69-73	insulin like growth factor 1 receptor	Homo sapiens	5-11
26990105-4	2016	The results from single-reference and multireference methods are cross-checked, and the amount of multireference character for both considered spin states of [Fe(H2O)6](3+) is carefully analyzed.	Iron	159-161	spindlin 1	Homo sapiens	143-147
25870938-3	2016	Mutations in 10 genes have been associated with NBIA that include Ceruloplasmin (Cp) and ferritin light chain (FTL), both directly involved in iron homeostasis, as well as Pantothenate Kinase 2 (PANK2), Phospholipase A2 group 6 (PLA2G6), Fatty acid hydroxylase 2 (FA2H), Coenzyme A synthase (COASY), C19orf12, WDR45 and DCAF17 (C2orf37).	Iron	143-147	ferritin light chain	Homo sapiens	89-109
25870938-3	2016	Mutations in 10 genes have been associated with NBIA that include Ceruloplasmin (Cp) and ferritin light chain (FTL), both directly involved in iron homeostasis, as well as Pantothenate Kinase 2 (PANK2), Phospholipase A2 group 6 (PLA2G6), Fatty acid hydroxylase 2 (FA2H), Coenzyme A synthase (COASY), C19orf12, WDR45 and DCAF17 (C2orf37).	Iron	143-147	ferritin light chain	Homo sapiens	111-114
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	4-8	pre-mRNA processing factor 40 homolog B	Homo sapiens	48-52
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	4-8	MAGE family member A3	Homo sapiens	54-58
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	4-8	fibroblast growth factor 23	Homo sapiens	70-74
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	96-100	pre-mRNA processing factor 40 homolog B	Homo sapiens	48-52
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	96-100	MAGE family member A3	Homo sapiens	54-58
26919691-4	2016	The iron component is fashioned by the proteins HypC, HypD, HypE, and HypF, which functionalize iron with cyanide and carbon monoxide.	Iron	96-100	fibroblast growth factor 23	Homo sapiens	70-74
26913489-0	2016	Theoretical Study of Spin Crossover in 30 Iron Complexes.	Iron	42-46	spindlin 1	Homo sapiens	21-25
26913489-1	2016	Iron complexes are important spin crossover (SCO) systems with vital roles in oxidative metabolism and promising technological potential.	Iron	0-4	spindlin 1	Homo sapiens	29-33
26635037-2	2016	Insufficient hepcidin is implicated in parenchymal iron overload in beta-thalassemia and approaches to increase hepcidin have therapeutic potential.	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	13-21
26854247-0	2016	Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells.	Iron	0-4	protein arginine methyltransferase 1	Homo sapiens	80-85
26545917-3	2016	In most eukaryotes, including Schizosaccharomyces pombe, FeS biogenesis involves interaction between the J-protein Jac1 and the multifunctional Hsp70 Ssc1.	Iron	57-60	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	115-119
26545917-3	2016	In most eukaryotes, including Schizosaccharomyces pombe, FeS biogenesis involves interaction between the J-protein Jac1 and the multifunctional Hsp70 Ssc1.	Iron	57-60	Hsp70 family ATPase SSC1	Saccharomyces cerevisiae S288C	150-154
26660635-11	2016	Specifically, transport of Fenton metals (Cu, Fe) into and Mn out of the mitochondria, a probable mechanism for lower MnSOD activity, may be a/the cause of PCB126-induced oxidative stress.	Iron	27-29	superoxide dismutase 2	Rattus norvegicus	118-123
26914026-0	2016	Correction: N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion.	Iron	138-142	N-myc downstream regulated 1	Homo sapiens	12-40
14611577-0	2003	Diagram X-ray emission spectra of a hollow atom: the Kh alpha1,2 and Kh beta1,3 hypersatellites of Fe.	Iron	99-101	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	72-79
26914026-0	2016	Correction: N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion.	Iron	138-142	N-myc downstream regulated 1	Homo sapiens	42-47
26865615-7	2016	Shawn regulates metal homeostasis, and we found in shawn mutants increased levels of manganese, calcium, and mitochondrial free iron.	Iron	128-132	shawn	Drosophila melanogaster	51-56
12839837-9	2003	Haptoglobin, cytochalasin D, and actinomycin inhibited the MHb-induced responses, whereas zinc protoporphyrin IX (a heme oxygenase inhibitor) or desferroxamine (an iron chelator) did not inhibit MHb-induced responses.	Iron	164-168	hemoglobin subunit gamma 2	Homo sapiens	59-62
14512884-9	2003	In conclusion, TfR2-alpha protein is likely to have a role in the mediation of Tf-Fe uptake by the NTfR1 process by HuH7 hepatoma cell in proliferating and stationary stages of growth.	Iron	82-84	MIR7-3 host gene	Homo sapiens	116-120
26608187-2	2016	Systemic iron homeostasis is predominantly regulated by the liver through the iron regulatory hormone hepcidin.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	102-110
14499533-10	2003	The AAPBe concentrations are linearly correlated with the concentrations of suspended sediment, particulate organic carbon, particulate nitrogen, particulate phosphorus, and the AAP for several transition metals (Al, Co, Cr, Fe, Mn, Ni and Y), and the lanthanides.	Iron	225-227	serpin family F member 2	Homo sapiens	4-7
12949720-2	2003	Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transporter-1 and FPN1, respectively, to transfer iron from the duodenal lumen to the circulation.	Iron	163-167	cytochrome b reductase 1	Homo sapiens	28-49
12949720-2	2003	Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transporter-1 and FPN1, respectively, to transfer iron from the duodenal lumen to the circulation.	Iron	163-167	hephaestin	Homo sapiens	54-64
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Iron	107-109	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	22-27
12949720-6	2003	Spearman rank correlations showed that Dcytb, hephaestin, FPN1, and DMT1 mRNA expression are positively related to each other independently of the underlying disease, which ensures an efficient transepithelial transport of absorbed iron.	Iron	232-236	cytochrome b reductase 1	Homo sapiens	39-44
12949720-6	2003	Spearman rank correlations showed that Dcytb, hephaestin, FPN1, and DMT1 mRNA expression are positively related to each other independently of the underlying disease, which ensures an efficient transepithelial transport of absorbed iron.	Iron	232-236	hephaestin	Homo sapiens	46-56
14535313-0	2003	Pilot-scale treatment of RDX-contaminated soil with zerovalent iron.	Iron	63-67	radixin	Homo sapiens	25-28
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Iron	131-133	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	22-27
14535313-2	2003	Our objective was to conduct laboratory and pilot-scale experiments to determine if zerovalent iron (Fe(0)) could effectively transform RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) in two LANL soils that differed in physicochemical properties (Soils A and B).	Iron	95-99	radixin	Homo sapiens	136-139
14535313-2	2003	Our objective was to conduct laboratory and pilot-scale experiments to determine if zerovalent iron (Fe(0)) could effectively transform RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) in two LANL soils that differed in physicochemical properties (Soils A and B).	Iron	101-106	radixin	Homo sapiens	136-139
14535313-3	2003	Laboratory tests indicated that Soil A was highly alkaline and needed to be acidified [with H2SO4, Al2(SO4)3, or CH3COOH] before Fe(0) could transform RDX.	Iron	129-131	radixin	Homo sapiens	151-154
14535313-6	2003	While adding CH3COOH improved the effectiveness of Fe(0) to remove RDX in Soil A (98% destruction), CH3COOH had a negative effect in Soil B.	Iron	51-56	radixin	Homo sapiens	67-70
14535313-9	2003	Despite problems encountered with CH3COOH, pilot-scale treatment of Soil B (12 100 mg RDX kg(-1)) with Fe(0) or Fe(0) + Al2(SO4)3 showed high RDX destruction (96-98%).	Iron	103-105	radixin	Homo sapiens	86-89
14535313-9	2003	Despite problems encountered with CH3COOH, pilot-scale treatment of Soil B (12 100 mg RDX kg(-1)) with Fe(0) or Fe(0) + Al2(SO4)3 showed high RDX destruction (96-98%).	Iron	103-105	radixin	Homo sapiens	142-145
14535313-9	2003	Despite problems encountered with CH3COOH, pilot-scale treatment of Soil B (12 100 mg RDX kg(-1)) with Fe(0) or Fe(0) + Al2(SO4)3 showed high RDX destruction (96-98%).	Iron	112-114	radixin	Homo sapiens	86-89
26829642-4	2016	Our aim was to analyse the impact of excess iron in Hfe-/- mice on osteoblast activity and on bone microarchitecture.	Iron	44-48	homeostatic iron regulator	Mus musculus	52-55
12904079-5	2003	Electron paramagnetic resonance spectroscopy shows that the formation of a low-spin methemoglobin-hydroxyurea complex is critical for iron nitrosyl hemoglobin formation.	Iron	134-138	hemoglobin subunit gamma 2	Homo sapiens	84-97
26829642-7	2016	We found that bone contains excess iron associated with increased hepatic iron concentration in Hfe-/- mice.	Iron	35-39	homeostatic iron regulator	Mus musculus	96-99
12950389-10	2003	Moreover, the p21(WAF1/CIP1) protein was accumulated in mouse-sensitive 38C13 cells under iron deprivation while all other cell lines tested, including human-sensitive cell line Raji, did not show any accumulation of p21(WAF1/CIP1) protein.	Iron	90-94	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	14-17
12950389-10	2003	Moreover, the p21(WAF1/CIP1) protein was accumulated in mouse-sensitive 38C13 cells under iron deprivation while all other cell lines tested, including human-sensitive cell line Raji, did not show any accumulation of p21(WAF1/CIP1) protein.	Iron	90-94	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	18-27
26829642-7	2016	We found that bone contains excess iron associated with increased hepatic iron concentration in Hfe-/- mice.	Iron	74-78	homeostatic iron regulator	Mus musculus	96-99
26818499-0	2016	Regulation of ATP13A2 via PHD2-HIF1alpha Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson"s Disease.	Iron	76-80	ATPase cation transporting 13A2	Homo sapiens	14-21
12885946-3	2003	Addition of iron before cytokine stimulation resulted in a dose-dependent reduction of these pathways, and iron restriction by desferrioxamine (DFO) enhanced ICAM-1, HLA-DR, and GTP-CH expression.	Iron	107-111	intercellular adhesion molecule 1	Homo sapiens	158-164
12885946-5	2003	IFN-gamma-inducible mRNA expression of ICAM-1, HLA-DR, and GTP-CH was reduced by iron and increased by DFO by a transcriptional mechanism.	Iron	81-85	intercellular adhesion molecule 1	Homo sapiens	39-45
12885946-6	2003	Moreover, ICAM-1 and to a lesser extent, GTP-CH and HLA-DR mRNA expression were regulated post-transcriptionally, as iron pretreatment resulted in shortening the mRNA half-life compared with cells treated with IFN-gamma alone.	Iron	117-121	intercellular adhesion molecule 1	Homo sapiens	10-16
26818499-7	2016	Knockdown of ATP13A2 expression within human DAergic cells was found to abrogate restoration of cellular iron homeostasis and neuronal cell viability elicited by inhibition of PHD2 under conditions of mitochondrial stress, likely via effects on lysosomal iron storage.	Iron	105-109	ATPase cation transporting 13A2	Homo sapiens	13-20
26818499-7	2016	Knockdown of ATP13A2 expression within human DAergic cells was found to abrogate restoration of cellular iron homeostasis and neuronal cell viability elicited by inhibition of PHD2 under conditions of mitochondrial stress, likely via effects on lysosomal iron storage.	Iron	255-259	ATPase cation transporting 13A2	Homo sapiens	13-20
26818499-8	2016	These data suggest that regulation of ATP13A2 by the PHD2-HIF1alpha signaling pathway affects cellular iron homeostasis and DAergic neuronal survival.	Iron	103-107	ATPase cation transporting 13A2	Homo sapiens	38-45
12868065-3	2003	Because iron has been shown to increase the in vitro toxicity of Abeta, the present study was undertaken to determine whether iron can make Abeta neurotoxic in vivo.	Iron	8-12	amyloid beta precursor protein	Rattus norvegicus	65-70
26818499-12	2016	Knockdown of ATP13A2, a gene linked to a rare juvenile form of Parkinson"s disease and recently identified as a novel HIF1alpha target, was found to abrogate maintenance of cellular iron homeostasis and neuronal viability elicited by PHD2 inhibition in vivo and in cultured dopaminergic cells under conditions of mitochondrial stress.	Iron	182-186	ATPase cation transporting 13A2	Homo sapiens	13-20
12868065-6	2003	Coinjection of iron with either Abeta variant caused significantly more neuronal loss than Abeta peptide alone, suggesting that iron may contribute to the toxicity associated with senile plaques.	Iron	15-19	amyloid beta precursor protein	Rattus norvegicus	32-37
12868065-6	2003	Coinjection of iron with either Abeta variant caused significantly more neuronal loss than Abeta peptide alone, suggesting that iron may contribute to the toxicity associated with senile plaques.	Iron	128-132	amyloid beta precursor protein	Rattus norvegicus	32-37
26818499-13	2016	Mechanistically, this was due to ATP13A2"s role in maintaining lysosomal iron stores.	Iron	73-77	ATPase cation transporting 13A2	Homo sapiens	33-40
26799040-1	2016	We report on the influence of uniaxial strain relief on the spin spiral state in the Fe double layer grown on Ir(111).	Iron	85-87	spindlin 1	Homo sapiens	60-64
12826281-5	2003	Remarkably, the enzymatic activity is restored when the [4Fe-4S] cluster is re-assembled in the endonuclease III dinitrosyl iron complex with L-cysteine, cysteine desulfurase (IscS) and ferrous iron in vitro.	Iron	124-128	endonuclease III	Escherichia coli	96-112
26799040-3	2016	Magnetic field-dependent spin-polarized STM measurements of the reconstructed Fe double layer reveal cycloidal spin spirals with a period on the nm scale.	Iron	78-80	spindlin 1	Homo sapiens	25-29
12826281-5	2003	Remarkably, the enzymatic activity is restored when the [4Fe-4S] cluster is re-assembled in the endonuclease III dinitrosyl iron complex with L-cysteine, cysteine desulfurase (IscS) and ferrous iron in vitro.	Iron	194-198	endonuclease III	Escherichia coli	96-112
26799040-3	2016	Magnetic field-dependent spin-polarized STM measurements of the reconstructed Fe double layer reveal cycloidal spin spirals with a period on the nm scale.	Iron	78-80	spindlin 1	Homo sapiens	111-115
26799040-5	2016	On an atomic scale the spin spiral propagation direction is linked to the [001] direction of the bcc(110)-like Fe, leading to a zigzag shaped wave front.	Iron	111-113	spindlin 1	Homo sapiens	23-27
12846576-1	2003	Functionally distinct conformations of HbA (human adult hemoglobin) were probed using deoxy and diliganded derivatives of symmetric Fe-Zn hybrids of HbA.	Iron	132-134	keratin 90, pseudogene	Homo sapiens	39-42
26383698-0	2016	A Proton Pump Inhibitor a Day Keeps the Iron Away.	Iron	40-44	ATPase H+/K+ transporting subunit alpha	Homo sapiens	2-13
12782026-1	2003	A continuous spectrofluorimetric assay for determining ferrochelatase activity has been developed using the physiological substrates ferrous iron and protoporphyrin IX under strictly anaerobic conditions.	Iron	141-145	ferrochelatase	Homo sapiens	55-69
12788784-5	2003	We review the data showing that lipocalins transport low-molecular-weight chemical signals and data indicating that 24p3/NGAL transports iron.	Iron	137-141	lipocalin 2	Homo sapiens	121-125
12788784-6	2003	We compare 24p3/NGAL to transferrin and a variety of other iron trafficking pathways and suggest specific roles for each in iron transport.	Iron	59-63	lipocalin 2	Homo sapiens	16-20
12788784-6	2003	We compare 24p3/NGAL to transferrin and a variety of other iron trafficking pathways and suggest specific roles for each in iron transport.	Iron	124-128	lipocalin 2	Homo sapiens	16-20
14509218-14	2003	In conclusion, CHr is an easily measurable and reliable marker of iron status in non-dialysis CRF patients.	Iron	66-70	chromate resistance; sulfate transport	Homo sapiens	15-18
14509218-15	2003	Moreover, the CHr level was also sensitive to iron alternations in non-dialysis CRF patients under rHuEPO treatment.	Iron	46-50	chromate resistance; sulfate transport	Homo sapiens	14-17
14509218-16	2003	Accordingly, if long-acting EPO is available for non-dialysis CRF patients, the CHr value is likely to be indicative of the need for iron supplementation.	Iron	133-137	chromate resistance; sulfate transport	Homo sapiens	80-83
12813369-3	2003	Mice deleted in the hfe gene (hfe-/-) abnormally accumulate iron in tissue; defects in the human hfe gene are clinically expressed as hemochromatosis.	Iron	60-64	homeostatic iron regulator	Mus musculus	20-23
12813369-3	2003	Mice deleted in the hfe gene (hfe-/-) abnormally accumulate iron in tissue; defects in the human hfe gene are clinically expressed as hemochromatosis.	Iron	60-64	homeostatic iron regulator	Mus musculus	30-33
12813369-6	2003	A preliminary (but underpowered) study suggested that iron-loaded hfe-/- mice had increased mortality as compared with hfe-/- mice fed a low-iron diet.	Iron	54-58	homeostatic iron regulator	Mus musculus	66-69
12813369-8	2003	A subsequent, appropriately powered study showed that iron-loaded hfe-/- mice had significantly higher mortality from intra-abdominal sepsis than hfe-/- mice fed a low-iron diet.	Iron	54-58	homeostatic iron regulator	Mus musculus	66-69
12813369-8	2003	A subsequent, appropriately powered study showed that iron-loaded hfe-/- mice had significantly higher mortality from intra-abdominal sepsis than hfe-/- mice fed a low-iron diet.	Iron	168-172	homeostatic iron regulator	Mus musculus	66-69
12522003-4	2003	Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition.	Iron	140-144	interleukin 10	Homo sapiens	188-202
12522003-4	2003	Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition.	Iron	242-246	interleukin 10	Homo sapiens	188-202
12522003-4	2003	Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition.	Iron	242-246	interleukin 10	Homo sapiens	204-209
12522003-9	2003	Opposite, the anti-inflammatory cytokine IL-10 stimulates TfR-mediated iron uptake into activated monocytes.	Iron	71-75	interleukin 10	Homo sapiens	41-46
12691842-1	2003	Genetic ablation of iron regulatory protein 2 (IRP-2), a protein responsible for post-transcriptional regulation of expression of several iron metabolism proteins, predisposes IRP-2 -/- mice to develop adult onset neurodegenerative disease.	Iron	20-24	iron responsive element binding protein 2	Mus musculus	47-52
12691842-1	2003	Genetic ablation of iron regulatory protein 2 (IRP-2), a protein responsible for post-transcriptional regulation of expression of several iron metabolism proteins, predisposes IRP-2 -/- mice to develop adult onset neurodegenerative disease.	Iron	20-24	iron responsive element binding protein 2	Mus musculus	176-181
12691842-5	2003	We detected increases in the number of pixels with low T(2) values expected from accumulations of iron in IRP-2 -/- mice.	Iron	98-102	iron responsive element binding protein 2	Mus musculus	106-111
12716753-3	2003	The present investigation was initiated to evaluate whether a carbohydrate-restricted, low-iron-available, polyphenol-enriched (CR-LIPE) diet may delay and improve the outcome of diabetic nephropathy to a greater extent than standard protein restriction.	Iron	91-95	lipase E, hormone sensitive type	Homo sapiens	131-135
12468424-2	2003	It has been proposed that mutations causing loss of function of HFE gene result in reduced iron incorporation into immature duodenal crypt cells.	Iron	91-95	homeostatic iron regulator	Mus musculus	64-67
12668611-0	2003	Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1).	Iron	0-4	ferroxidase	Saccharomyces cerevisiae S288C	79-83
12668611-13	2003	Our results suggest that Yfh1 mediates iron use by ferrochelatase.	Iron	39-43	ferroxidase	Saccharomyces cerevisiae S288C	25-29
12565710-4	2003	The aim of this study was to investigate if feeding with carbonyl iron (CI) facilitates the development of carbon tetrachloride (CCl4)-induced liver fibrosis in the mouse.	Iron	66-70	chemokine (C-C motif) ligand 4	Mus musculus	129-133
12565710-4	2003	The aim of this study was to investigate if feeding with carbonyl iron (CI) facilitates the development of carbon tetrachloride (CCl4)-induced liver fibrosis in the mouse.	Iron	72-74	chemokine (C-C motif) ligand 4	Mus musculus	129-133
12565710-6	2003	Hepatic iron content increased 15- and 22-fold in animals receiving CI and CI + CCl4.	Iron	8-12	chemokine (C-C motif) ligand 4	Mus musculus	80-84
12565710-9	2003	Conversely, a marked collagen deposition was observed in CCl4 and CI + CCl4 groups.	Iron	66-70	chemokine (C-C motif) ligand 4	Mus musculus	71-75
12565710-12	2003	These results demonstrate that the addition of iron facilitates the development of cirrhosis in animals exposed to subtoxic doses of CCl4.	Iron	47-51	chemokine (C-C motif) ligand 4	Mus musculus	133-137
12646708-2	2003	nFbp was reconstituted as a stable iron containing protein by using a number of different exogenous anions [arsenate, citrate, nitrilotriacetate, pyrophosphate, and oxalate (symbolized by X)] in addition to phosphate, predominantly present in the recombinant form of the protein.	Iron	35-39	programmed cell death 11	Homo sapiens	0-4
12540839-6	2003	These results revealed that YC-1 facilitated cleavage of the proximal His-iron bond and caused geometrical distortion of the five-coordinate NO-heme.	Iron	74-78	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32
12540839-7	2003	Resonance Raman studies demonstrated the presence of two iron-CO stretch modes at 488 and 521 cm(-1) specific to the YC-1-bound CO complex of the native enzyme.	Iron	57-61	RNA binding motif single stranded interacting protein 1	Homo sapiens	117-121
12540839-9	2003	These results indicate that YC-1 stimulates enzyme activity by weakening or cleaving the proximal His-iron bond in the CO complex as well as the NO complex.	Iron	102-106	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32
12556365-4	2003	Catalytically active intracellular iron was markedly increased in hemin-treated IRPTCs and contributed to the induction of HO-1 and MCP-1 mRNA because an iron chelator blocked hemin-induced upregulation of both genes, whereas a cell-permeant form of iron directly induced these genes.	Iron	35-39	heme oxygenase 1	Rattus norvegicus	123-127
12556365-4	2003	Catalytically active intracellular iron was markedly increased in hemin-treated IRPTCs and contributed to the induction of HO-1 and MCP-1 mRNA because an iron chelator blocked hemin-induced upregulation of both genes, whereas a cell-permeant form of iron directly induced these genes.	Iron	154-158	heme oxygenase 1	Rattus norvegicus	123-127
12556365-4	2003	Catalytically active intracellular iron was markedly increased in hemin-treated IRPTCs and contributed to the induction of HO-1 and MCP-1 mRNA because an iron chelator blocked hemin-induced upregulation of both genes, whereas a cell-permeant form of iron directly induced these genes.	Iron	154-158	heme oxygenase 1	Rattus norvegicus	123-127
12584213-0	2003	A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption.	Iron	122-126	RoBo-1	Rattus norvegicus	38-42
12593860-1	2003	Heme oxygenase-1 (HO-1) is an inducible form of heme oxygenase that catabolizes heme to carbon monoxide, biliverdin, and ferrous iron.	Iron	121-133	heme oxygenase 1	Rattus norvegicus	0-16
12593860-1	2003	Heme oxygenase-1 (HO-1) is an inducible form of heme oxygenase that catabolizes heme to carbon monoxide, biliverdin, and ferrous iron.	Iron	121-133	heme oxygenase 1	Rattus norvegicus	18-22
12608554-2	2003	Iron status of the patients can be determined from the recently available measurement of content of reticulocyte hemoglobin (CHr).	Iron	0-4	chromate resistance; sulfate transport	Homo sapiens	125-128
12608554-9	2003	CHr significantly correlated with iron parameters in the dialysis patients.	Iron	34-38	chromate resistance; sulfate transport	Homo sapiens	0-3
12608554-12	2003	CONCLUSIONS: CHr, measured simultaneously with Hct, is a sensitive and specific marker of iron status in dialysis patients.	Iron	90-94	chromate resistance; sulfate transport	Homo sapiens	13-16
12542703-2	2003	Oxygenation occurs at the binuclear iron active centre in the hydroxylase component (MMOH), to which electrons are passed from NAD(P)H via the reductase component (MMOR), along a pathway that is facilitated and controlled by the third component, protein B (MMOB).	Iron	36-40	prolyl 3-hydroxylase 3	Homo sapiens	246-255
15841243-2	2003	Here we have sequenced and characterized a full-length cDNA encoding a putative iron-binding transferrin (AmTRF) in the honeybee.	Iron	80-84	transferrin	Apis mellifera	93-104
12849737-1	2003	The present investigation was carried out to elucidate the effect of the antimalarial drug quinacrine on levels of expression of the non-heme iron transporter, divalent metal transporter-1 (DMT1) and iron, in the hippocampus of rats after kainate treatment.	Iron	142-146	RoBo-1	Rattus norvegicus	160-188
12849737-3	2003	The increased DMT1 immunoreactivity was correlated with increased levels of Fe3+ and Fe2+ staining in the CA fields, as demonstrated by iron histochemistry (Perl"s and Turnbull"s blue stain for Fe3+ and Fe2+).	Iron	136-140	RoBo-1	Rattus norvegicus	14-18
12849737-7	2003	These results show that DMT1 expression is closely linked to iron levels, and provide further support for a crucial role that DMT1 plays in iron accumulation in the degenerating hippocampus.	Iron	61-65	RoBo-1	Rattus norvegicus	24-28
12849737-7	2003	These results show that DMT1 expression is closely linked to iron levels, and provide further support for a crucial role that DMT1 plays in iron accumulation in the degenerating hippocampus.	Iron	140-144	RoBo-1	Rattus norvegicus	24-28
12849737-7	2003	These results show that DMT1 expression is closely linked to iron levels, and provide further support for a crucial role that DMT1 plays in iron accumulation in the degenerating hippocampus.	Iron	140-144	RoBo-1	Rattus norvegicus	126-130
12445862-7	2002	In order to figure out whether or not doxorubicin can utilize iron from the transport protein transferrin for complex formation and prooxidative activities we studied the redox state of iron and its regulatory control by ceruloplasmin and ascorbate in the plasma of dogs suffering from malignant lymphoma by electron spin resonance spectroscopy.	Iron	186-190	ceruloplasmin	Canis lupus familiaris	221-234
12481078-7	2002	In addition, AtHO1 required an iron chelator and second reductant, such as ascorbate, for full activity.	Iron	31-35	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	13-18
12460733-2	2002	Divalent metal transporter-1 (DMT-1) is primarily responsible for dietary iron uptake in the duodenum but also recognizes nonessential metals such as cadmium (Cd).	Iron	74-78	RoBo-1	Rattus norvegicus	0-28
28214898-4	2016	Prenatal LPS treatment significantly increased the density of parvalbumin-immunoreactive neurons at P14 in the medial PFC, dorsolateral PFC, and ventral subiculum of offspring born from iron-sufficient but not iron-deficient dams.	Iron	186-190	parvalbumin	Rattus norvegicus	62-73
12460733-2	2002	Divalent metal transporter-1 (DMT-1) is primarily responsible for dietary iron uptake in the duodenum but also recognizes nonessential metals such as cadmium (Cd).	Iron	74-78	RoBo-1	Rattus norvegicus	30-35
12200425-11	2002	This model is supported by the behavior of "aspartate oxidase" (aspartate:fumarate oxidoreductase), an Frd homologue that lacks Fe-S clusters.	Iron	128-132	oxidoreductase	Escherichia coli	83-97
26457379-13	2016	FE allows direct visualization of a prognostic parameter (here MMP-2/-9) on a molecular level and may improve the characterization of colorectal lesions and the adenoma detection rate in the future.	Iron	0-2	matrix metallopeptidase 2	Mus musculus	63-71
12547229-17	2002	The results confirm the essential role of DMT1 in the uptake phase of non-heme iron absorption.	Iron	79-83	RoBo-1	Rattus norvegicus	42-46
12547229-18	2002	When normal rats previously fed a low iron diet were given a bolus of iron by stomach tube, the subsequent absorption of iron from a test dose placed in the duodenum diminished in parallel with the expression of DMT1 mRNA and protein, commencing within 1hour and reaching low levels by 7 hours.	Iron	38-42	RoBo-1	Rattus norvegicus	212-216
12547229-18	2002	When normal rats previously fed a low iron diet were given a bolus of iron by stomach tube, the subsequent absorption of iron from a test dose placed in the duodenum diminished in parallel with the expression of DMT1 mRNA and protein, commencing within 1hour and reaching low levels by 7 hours.	Iron	70-74	RoBo-1	Rattus norvegicus	212-216
12547229-18	2002	When normal rats previously fed a low iron diet were given a bolus of iron by stomach tube, the subsequent absorption of iron from a test dose placed in the duodenum diminished in parallel with the expression of DMT1 mRNA and protein, commencing within 1hour and reaching low levels by 7 hours.	Iron	70-74	RoBo-1	Rattus norvegicus	212-216
12547229-20	2002	These results show the level of expression and intracellular distribution and function of DMT1 respond very quickly to the iron content of the diet as well as being affected by storage iron levels.	Iron	123-127	RoBo-1	Rattus norvegicus	90-94
12547229-20	2002	These results show the level of expression and intracellular distribution and function of DMT1 respond very quickly to the iron content of the diet as well as being affected by storage iron levels.	Iron	185-189	RoBo-1	Rattus norvegicus	90-94
12547230-1	2002	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	aconitase 1	Mus musculus	26-30
12547230-1	2002	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	iron responsive element binding protein 2	Mus musculus	35-39
12547230-4	2002	), a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels and a decrease in ferritin synthesis.	Iron	65-69	aconitase 1	Mus musculus	84-88
12547230-8	2002	These results suggest that NO(+)-mediated degradation of IRP2 plays a major role in iron metabolism during inflammation.	Iron	84-88	iron responsive element binding protein 2	Mus musculus	57-61
27980269-4	2016	Throughout the clinical course, dROM and 8-OHdG correlated significantly with WT1 and with ferritin, suggesting that changes in the oxidative stress marker levels reflect not only iron overload but also disease progression of MDS.	Iron	180-184	Drosomycin	Drosophila melanogaster	32-36
12553165-18	2002	The second part of the thesis encompasses the circulation of iron in the extracellular fluids of the brain, i.e. the brain interstitial fluid and the CSF.	Iron	61-65	colony stimulating factor 2	Rattus norvegicus	150-153
12553165-20	2002	As the choroid plexus is known to synthesize transferrin, a key question is whether transferrin of the CSF might play a role for iron homeostasis by diffusing from the ventricles and subarachnoid space to the brain interstitium.	Iron	129-133	colony stimulating factor 2	Rattus norvegicus	103-106
12553165-40	2002	Instead, transferrin of the CSF probably plays a significant role for neutralization and export to the blood of metals, including iron.	Iron	130-134	colony stimulating factor 2	Rattus norvegicus	28-31
27642607-2	2016	Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition.	Iron	135-139	growth differentiation factor 15	Homo sapiens	0-32
12374293-1	2002	IRT1 and IRT2 are members of the Arabidopsis ZIP metal transporter family that are specifically induced by iron deprivation in roots and act as heterologous suppressors of yeast mutations inhibiting iron and zinc uptake.	Iron	107-111	iron-regulated transporter 1	Arabidopsis thaliana	0-4
12374293-1	2002	IRT1 and IRT2 are members of the Arabidopsis ZIP metal transporter family that are specifically induced by iron deprivation in roots and act as heterologous suppressors of yeast mutations inhibiting iron and zinc uptake.	Iron	199-203	iron-regulated transporter 1	Arabidopsis thaliana	0-4
12374293-4	2002	Pulse labeling with 59Fe through the root system shows that the irt1 mutation reduces iron accumulation in the shoots.	Iron	86-90	iron-regulated transporter 1	Arabidopsis thaliana	64-68
12374293-6	2002	In comparison to wild-type, the irt1 mutant responds to iron and zinc deprivation by altered expression of certain zinc and iron transporter genes, which results in the activation of ZIP1 in shoots, reduction of ZIP2 transcript levels in roots, and enhanced expression of IRT2 in roots.	Iron	56-60	iron-regulated transporter 1	Arabidopsis thaliana	32-36
27642607-2	2016	Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition.	Iron	135-139	growth differentiation factor 15	Homo sapiens	34-40
12374293-7	2002	These data support the conclusion that IRT1 is an essential metal transporter required for proper development and regulation of iron and zinc homeostasis in Arabidopsis.	Iron	128-132	iron-regulated transporter 1	Arabidopsis thaliana	39-43
26719882-1	2016	BACKGROUND: Mutations in the Fe-S cluster-containing SDHB subunit of succinate dehydrogenase cause familial cancer syndromes.	Iron	29-33	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	53-57
12183449-0	2002	C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	46-54
26719882-6	2016	Biochemical and bioinformatic screening revealed that 37% of disease-causing missense mutations in SDHB were located in either the L(I)YR Fe-S transfer motifs or in the 11 Fe-S cluster-ligating cysteines.	Iron	138-142	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	99-103
12183449-2	2002	Originally identified as a gene up-regulated by iron overload in mouse liver, the HEPC gene encodes hepcidin, the first mammalian liver-specific antimicrobial peptide and potential key regulator of iron metabolism.	Iron	48-52	hepcidin antimicrobial peptide	Mus musculus	82-86
12183449-2	2002	Originally identified as a gene up-regulated by iron overload in mouse liver, the HEPC gene encodes hepcidin, the first mammalian liver-specific antimicrobial peptide and potential key regulator of iron metabolism.	Iron	48-52	hepcidin antimicrobial peptide	Mus musculus	100-108
26719882-6	2016	Biochemical and bioinformatic screening revealed that 37% of disease-causing missense mutations in SDHB were located in either the L(I)YR Fe-S transfer motifs or in the 11 Fe-S cluster-ligating cysteines.	Iron	172-176	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	99-103
12183449-2	2002	Originally identified as a gene up-regulated by iron overload in mouse liver, the HEPC gene encodes hepcidin, the first mammalian liver-specific antimicrobial peptide and potential key regulator of iron metabolism.	Iron	198-202	hepcidin antimicrobial peptide	Mus musculus	82-86
12183449-2	2002	Originally identified as a gene up-regulated by iron overload in mouse liver, the HEPC gene encodes hepcidin, the first mammalian liver-specific antimicrobial peptide and potential key regulator of iron metabolism.	Iron	198-202	hepcidin antimicrobial peptide	Mus musculus	100-108
26757915-0	2016	Iron depletion strategy for targeted cancer therapy: utilizing the dual roles of neutrophil gelatinase-associated lipocalin protein.	Iron	0-4	lipocalin 2	Homo sapiens	81-123
12183449-11	2002	Decrease of hepcidin mRNA in mice lacking hepatic C/EBPalpha was accompanied by iron accumulation in periportal hepatocytes.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	12-20
12183449-12	2002	Finally, iron overload led to a significant increase of C/EBPalpha protein and HEPC transcripts in mouse liver.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	79-83
12183449-13	2002	Taken together, these data demonstrate that C/EBPalpha is likely to be a key regulator of HEPC gene transcription and provide a novel mechanism for cross-talk between the C/EBP pathway and iron metabolism.	Iron	189-193	hepcidin antimicrobial peptide	Mus musculus	90-94
26757915-2	2016	Applying the dual function of neutrophil gelatinase-associated lipocalin (NGAL) could achieve the goal of iron depletion in the cancer cells.	Iron	106-110	lipocalin 2	Homo sapiens	30-72
26757915-2	2016	Applying the dual function of neutrophil gelatinase-associated lipocalin (NGAL) could achieve the goal of iron depletion in the cancer cells.	Iron	106-110	lipocalin 2	Homo sapiens	74-78
26757915-3	2016	Tyr106, Lys125 or Lys134 was the key binding site for NGAL protein to sequester iron-chelating siderophores.	Iron	80-84	lipocalin 2	Homo sapiens	54-58
12367526-3	2002	In particular, we have identified an area of significant sequence similarity between a three contiguous membrane-spanning domain of cytochrome b, which contains binding sites for two hemes, and a three contiguous membrane-spanning domain in the photosynthetic reaction center core subunits, which contains binding sites for cofactors such as (bacterio)chlorophylls, (bacterio)pheophytin and a non-heme iron.	Iron	402-406	mitochondrially encoded cytochrome b	Homo sapiens	132-144
12242109-7	2002	Iron chelation also causes hypophosphorylation of the retinoblastoma protein (pRb) and decreases the expression of cyclins A, B and D, which are vital for cell cycle progression.	Iron	0-4	RB transcriptional corepressor 1	Mus musculus	78-81
12242109-14	2002	Iron chelation also markedly increases the mRNA levels of the p53-inducible cyclin-dependent kinase (cdk) inhibitor, p21(WAF1/CIP1).	Iron	0-4	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	117-120
26652203-10	2015	Potential energy surface scans with successive elongation of the Fe-M bonds allow an estimation of the iron-metal bond dissociation energies (BDE) as BDE(Fe-Ni) = 11.3 kcal mol(-1) and BDE(Fe-Pd) = 24.3 kcal mol(-1).	Iron	103-107	homeobox D13	Homo sapiens	142-145
12242109-14	2002	Iron chelation also markedly increases the mRNA levels of the p53-inducible cyclin-dependent kinase (cdk) inhibitor, p21(WAF1/CIP1).	Iron	0-4	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	121-130
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	101-105	transferrin	Mus musculus	77-88
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	101-105	transferrin	Mus musculus	190-201
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	171-175	transferrin	Mus musculus	77-88
12239176-1	2002	Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified endosomes.	Iron	171-175	transferrin	Mus musculus	190-201
26652203-10	2015	Potential energy surface scans with successive elongation of the Fe-M bonds allow an estimation of the iron-metal bond dissociation energies (BDE) as BDE(Fe-Ni) = 11.3 kcal mol(-1) and BDE(Fe-Pd) = 24.3 kcal mol(-1).	Iron	103-107	homeobox D13	Homo sapiens	150-153
26652203-10	2015	Potential energy surface scans with successive elongation of the Fe-M bonds allow an estimation of the iron-metal bond dissociation energies (BDE) as BDE(Fe-Ni) = 11.3 kcal mol(-1) and BDE(Fe-Pd) = 24.3 kcal mol(-1).	Iron	103-107	homeobox D13	Homo sapiens	150-153
26456104-3	2015	HFE influences iron absorption by modulating the expression of hepcidin, the main controller of iron metabolism.	Iron	15-19	homeostatic iron regulator	Mus musculus	0-3
12442748-0	2002	Energy spectrum of 50-250 MeV/nucleon iron nuclei inside the MIR space craft.	Iron	38-42	membrane associated ring-CH-type finger 8	Homo sapiens	61-64
26456104-3	2015	HFE influences iron absorption by modulating the expression of hepcidin, the main controller of iron metabolism.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	63-71
12237230-0	2002	Deletions in the loop surrounding the iron-sulfur cluster of adrenodoxin severely affect the interactions with its native redox partners adrenodoxin reductase and cytochrome P450(scc) (CYP11A1).	Iron	38-42	ferredoxin reductase	Bos taurus	137-158
12237230-0	2002	Deletions in the loop surrounding the iron-sulfur cluster of adrenodoxin severely affect the interactions with its native redox partners adrenodoxin reductase and cytochrome P450(scc) (CYP11A1).	Iron	38-42	SCC	Bos taurus	163-183
26456104-3	2015	HFE influences iron absorption by modulating the expression of hepcidin, the main controller of iron metabolism.	Iron	96-100	homeostatic iron regulator	Mus musculus	0-3
12237230-7	2002	In contrast, all mutations in the protein loop influence the binding to the redox partners adrenodoxin reductase (AdR) and cytochrome P450(scc) (CYP11A1) indicating the importance of this loop for the physiological function of this iron--sulfur protein.	Iron	232-236	ferredoxin reductase	Bos taurus	91-112
12237230-7	2002	In contrast, all mutations in the protein loop influence the binding to the redox partners adrenodoxin reductase (AdR) and cytochrome P450(scc) (CYP11A1) indicating the importance of this loop for the physiological function of this iron--sulfur protein.	Iron	232-236	ferredoxin reductase	Bos taurus	114-117
26456104-3	2015	HFE influences iron absorption by modulating the expression of hepcidin, the main controller of iron metabolism.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	63-71
12237230-7	2002	In contrast, all mutations in the protein loop influence the binding to the redox partners adrenodoxin reductase (AdR) and cytochrome P450(scc) (CYP11A1) indicating the importance of this loop for the physiological function of this iron--sulfur protein.	Iron	232-236	SCC	Bos taurus	123-143
26456104-6	2015	We describe the pertinence of HFE and HFE to mechanisms of iron homeostasis, the origin and fixation of HFE polymorphisms in European and other populations, and the genetic and biochemical basis of HFE hemochromatosis and iron overload.	Iron	59-63	homeostatic iron regulator	Mus musculus	30-33
26456104-6	2015	We describe the pertinence of HFE and HFE to mechanisms of iron homeostasis, the origin and fixation of HFE polymorphisms in European and other populations, and the genetic and biochemical basis of HFE hemochromatosis and iron overload.	Iron	59-63	homeostatic iron regulator	Mus musculus	38-41
26456104-6	2015	We describe the pertinence of HFE and HFE to mechanisms of iron homeostasis, the origin and fixation of HFE polymorphisms in European and other populations, and the genetic and biochemical basis of HFE hemochromatosis and iron overload.	Iron	59-63	homeostatic iron regulator	Mus musculus	38-41
26460247-0	2015	Genetic contribution to iron status: SNPs related to iron deficiency anaemia and fine mapping of CACNA2D3 calcium channel subunit.	Iron	24-28	calcium voltage-gated channel auxiliary subunit alpha2delta 3	Homo sapiens	97-105
12221295-0	2002	Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis.	Iron	14-18	ferroxidase	Saccharomyces cerevisiae S288C	91-96
12221295-0	2002	Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis.	Iron	64-68	ferroxidase	Saccharomyces cerevisiae S288C	91-96
12221295-0	2002	Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis.	Iron	105-109	ferroxidase	Saccharomyces cerevisiae S288C	91-96
25891252-0	2015	GNPAT variant associated with severe iron overload in HFE hemochromatosis.	Iron	37-41	glyceronephosphate O-acyltransferase	Homo sapiens	0-5
12221295-1	2002	Decreased expression of Yfh1p in the budding yeast, Saccharomyces cerevisiae, and the orthologous human gene frataxin results in respiratory deficiency and mitochondrial iron accumulation.	Iron	170-174	ferroxidase	Saccharomyces cerevisiae S288C	24-29
12221295-2	2002	The absence of Yfh1p decreases mitochondrial iron export.	Iron	45-49	ferroxidase	Saccharomyces cerevisiae S288C	15-20
12221295-4	2002	In the absence of Yfh1p, activity of Fe-S-containing enzymes (aconitase, succinate dehydrogenase) is decreased, whereas the activity of a non-Fe-S-containing enzyme (malate dehydrogenase) is unaffected.	Iron	37-41	ferroxidase	Saccharomyces cerevisiae S288C	18-23
12221295-6	2002	These results demonstrate a direct role of Yfh1p in the formation of Fe-S clusters and indicate that mitochondrial iron export requires Fe-S cluster biosynthesis.	Iron	69-73	ferroxidase	Saccharomyces cerevisiae S288C	43-48
12221295-6	2002	These results demonstrate a direct role of Yfh1p in the formation of Fe-S clusters and indicate that mitochondrial iron export requires Fe-S cluster biosynthesis.	Iron	115-119	ferroxidase	Saccharomyces cerevisiae S288C	43-48
25968977-8	2015	Benzodiazepine diazepam partially prevented decrease in cell survival following exposure to CS and redox active iron containing media (saliva) while benzodiazepine clonazepam did not, indicating that this effect is TSPO-specific.	Iron	112-116	translocator protein	Homo sapiens	215-219
12198710-5	2002	RESULTS: Iron absorption increased 2.7-fold within 6 days of switching to an iron-deficient diet and was accompanied by an increase in the duodenal expression of Dcytb, divalent metal transporter 1, and Ireg1.	Iron	9-13	RoBo-1	Rattus norvegicus	169-197
12387362-0	2002	Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun.	Iron	25-29	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	148-153
26468517-0	2015	Auxin Resistant1 and PIN-FORMED2 Protect Lateral Root Formation in Arabidopsis under Iron Stress.	Iron	85-89	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-16
12207649-0	2002	The metal ion transporter IRT1 is necessary for iron homeostasis and efficient photosynthesis in Arabidopsis thaliana.	Iron	48-52	iron-regulated transporter 1	Arabidopsis thaliana	26-30
12207649-7	2002	This, together with the finding that irt1-1 can be complemented by 35S::IRT1 but not by 35S::IRT2, demonstrates that, although the products of the two genes are closely related, only AtIRT1 is required for iron homeostasis under physiological conditions.	Iron	206-210	iron-regulated transporter 1	Arabidopsis thaliana	183-189
26468517-7	2015	We show that Auxin Resistant1 (AUX1) is a critical component in the mediation of endogenous ethylene effects on LR formation under excess Fe stress.	Iron	138-140	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	13-29
26468517-7	2015	We show that Auxin Resistant1 (AUX1) is a critical component in the mediation of endogenous ethylene effects on LR formation under excess Fe stress.	Iron	138-140	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	31-35
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	57-59	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	185-189
12427107-4	2002	Novel genes associated with iron uptake include Dcytb, a putative iron-regulated reductase and DMT1, a Fe(II) carrier in the brush border membrane.	Iron	28-32	cytochrome b reductase 1	Homo sapiens	48-53
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	262-264	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	185-189
26440452-4	2015	We now demonstrate this effect with a reduced hexanuclear iron cluster that achieves an S = 19/2 (chi(M)T   53 cm(3) K/mol) ground state that persists to 300 K, representing the largest spin ground state persistent to room temperature reported to date.	Iron	58-62	spindlin 1	Homo sapiens	186-190
12160900-0	2002	Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A.	Iron	0-4	SLAM family member 7	Homo sapiens	93-96
26318285-5	2015	The FAC-induced iron overload triggered mitochondrial fragmentation, which was accompanied by Drp1(Ser637) dephosphorylation.	Iron	16-20	collapsin response mediator protein 1	Mus musculus	94-98
12149232-0	2002	Regulation of iron absorption in Hfe mutant mice.	Iron	14-18	homeostatic iron regulator	Mus musculus	33-36
12149232-6	2002	Similarly, the iron loading associated with age in Hfe mutant mice resulted in nearly a 4-fold reduction in iron absorption.	Iron	15-19	homeostatic iron regulator	Mus musculus	51-54
12149232-6	2002	Similarly, the iron loading associated with age in Hfe mutant mice resulted in nearly a 4-fold reduction in iron absorption.	Iron	108-112	homeostatic iron regulator	Mus musculus	51-54
12149232-7	2002	When mice were stimulated to absorb iron either by depleting iron stores or by inducing erythropoiesis, wild type and Hfe mutant strains increased absorption to similar levels, approximately 5-fold over control values.	Iron	36-40	homeostatic iron regulator	Mus musculus	118-121
26318285-6	2015	Iron chelation with deferoxamine prevented the FAC-induced mitochondrial fragmentation and apoptotic cell death by inhibiting Drp1(Ser637) dephosphorylation.	Iron	0-4	collapsin response mediator protein 1	Mus musculus	126-130
12149232-8	2002	Our data indicate that Hfe mutant mice retain the ability to regulate iron absorption.	Iron	70-74	homeostatic iron regulator	Mus musculus	23-26
12149233-2	2002	The enzymatic defect of protoporphyria is a deficiency in ferrochelatase, which chelates iron and protoporphyrin IX to form heme.	Iron	89-93	ferrochelatase	Mus musculus	58-72
26318285-8	2015	FK506 and cyclosporine A, inhibitors of calcineurin activation, determined that calcineurin was associated with the iron-induced changes in mitochondrial morphology and the phosphorylation levels of Drp1.	Iron	116-120	collapsin response mediator protein 1	Mus musculus	199-203
26318285-10	2015	Therefore, these findings suggest that calcineurin-mediated phosphorylation of Drp1(Ser637) acts as a key regulator of neuronal cell loss by modulating mitochondrial dynamics in iron-induced toxicity.	Iron	178-182	collapsin response mediator protein 1	Mus musculus	79-83
26525136-6	2015	The spin-spin coupling between two neighboring Fe atoms along the b axis, which is realized by the Fe-S   S-Fe super-super exchange mechanism, was found to be responsible for this magnetic phase transition.	Iron	47-49	spindlin 1	Homo sapiens	4-8
12165551-4	2002	Patients receiving higher doses of IL-10 developed anemia and presented with a dose-dependent increase of ferritin and soluble transferrin receptor levels, an indicator of iron restriction to erythroid progenitor cells.	Iron	172-176	interleukin 10	Homo sapiens	35-40
12165551-7	2002	Our data demonstrate that IL-10 causes anemia in patients with inflammatory bowel disease which may be referred to the induction of imbalances in iron homeostasis by the cytokine, leading to hyperferritinemia and limited iron availability to erythroid progenitor cells, a condition typically seen in the anemia of chronic inflammation.	Iron	146-150	interleukin 10	Homo sapiens	26-31
12165551-7	2002	Our data demonstrate that IL-10 causes anemia in patients with inflammatory bowel disease which may be referred to the induction of imbalances in iron homeostasis by the cytokine, leading to hyperferritinemia and limited iron availability to erythroid progenitor cells, a condition typically seen in the anemia of chronic inflammation.	Iron	221-225	interleukin 10	Homo sapiens	26-31
12201358-2	2002	Heme oxygenase-1 (HO-1) is a tissue protective molecule which degrades heme into carbon monoxide (CO), free iron and biliverdin.	Iron	108-112	heme oxygenase 1	Rattus norvegicus	0-16
12201358-2	2002	Heme oxygenase-1 (HO-1) is a tissue protective molecule which degrades heme into carbon monoxide (CO), free iron and biliverdin.	Iron	108-112	heme oxygenase 1	Rattus norvegicus	18-22
26525136-6	2015	The spin-spin coupling between two neighboring Fe atoms along the b axis, which is realized by the Fe-S   S-Fe super-super exchange mechanism, was found to be responsible for this magnetic phase transition.	Iron	47-49	spindlin 1	Homo sapiens	9-13
12196181-2	2002	In erythroid cells the vast majority of Fe released from endosomes must cross both the outer and the inner mitochondrial membranes to reach ferrochelatase, which inserts Fe into protoporphyrin IX.	Iron	40-42	ferrochelatase	Homo sapiens	140-154
12196181-2	2002	In erythroid cells the vast majority of Fe released from endosomes must cross both the outer and the inner mitochondrial membranes to reach ferrochelatase, which inserts Fe into protoporphyrin IX.	Iron	170-172	ferrochelatase	Homo sapiens	140-154
26525136-6	2015	The spin-spin coupling between two neighboring Fe atoms along the b axis, which is realized by the Fe-S   S-Fe super-super exchange mechanism, was found to be responsible for this magnetic phase transition.	Iron	99-101	spindlin 1	Homo sapiens	4-8
12196181-3	2002	Based on the fact that Fe is specifically targeted into erythroid mitochondria, we have proposed that a transient mitochondria-endosome interaction is involved in Fe transfer to ferrochelatase [Ponka (1997) Blood 89, 1-25].	Iron	23-25	ferrochelatase	Homo sapiens	178-192
12196193-3	2002	Wu, Polack and Dalla-Favera [(1999) Science 283, 676-679] showed reciprocal control of H-ferritin and IRP2 by c-Myc, and suggest that c-Myc regulates genes to increase cytoplasmic iron.	Iron	180-184	ferritin heavy polypeptide 1	Mus musculus	87-97
26525136-6	2015	The spin-spin coupling between two neighboring Fe atoms along the b axis, which is realized by the Fe-S   S-Fe super-super exchange mechanism, was found to be responsible for this magnetic phase transition.	Iron	99-101	spindlin 1	Homo sapiens	9-13
12196193-3	2002	Wu, Polack and Dalla-Favera [(1999) Science 283, 676-679] showed reciprocal control of H-ferritin and IRP2 by c-Myc, and suggest that c-Myc regulates genes to increase cytoplasmic iron.	Iron	180-184	iron responsive element binding protein 2	Mus musculus	102-106
26525136-6	2015	The spin-spin coupling between two neighboring Fe atoms along the b axis, which is realized by the Fe-S   S-Fe super-super exchange mechanism, was found to be responsible for this magnetic phase transition.	Iron	99-101	spindlin 1	Homo sapiens	4-8
26525136-6	2015	The spin-spin coupling between two neighboring Fe atoms along the b axis, which is realized by the Fe-S   S-Fe super-super exchange mechanism, was found to be responsible for this magnetic phase transition.	Iron	99-101	spindlin 1	Homo sapiens	9-13
26525137-3	2015	Iron reduction (FeR) was responsible for 73-81% of total microbial carbon mineralization in September 2012 and 32-61% in February 2014.	Iron	0-4	FER tyrosine kinase	Homo sapiens	16-19
26579185-8	2015	Finally, in mpk3, mpk6, and acs2 mutants under conditions of Fe deficiency, induction of transcript expression of the Fe-deficiency response genes FRO2, IRT1, and FIT is partially compromised.	Iron	61-63	mitogen-activated protein kinase 3	Arabidopsis thaliana	12-16
12096107-2	2002	A cDNA clone highly homologous to the Arabidopsis Fe(II) transporter gene IRT1 was isolated from Fe-deficient rice roots.	Iron	50-52	iron-regulated transporter 1	Arabidopsis thaliana	74-78
26579185-8	2015	Finally, in mpk3, mpk6, and acs2 mutants under conditions of Fe deficiency, induction of transcript expression of the Fe-deficiency response genes FRO2, IRT1, and FIT is partially compromised.	Iron	61-63	MAP kinase 6	Arabidopsis thaliana	18-22
12124425-5	2002	When iron in the culture medium increased from 1 to 40 microm, IRP2 activity decreased to nil.	Iron	5-9	iron responsive element binding protein 2	Mus musculus	63-67
26579185-9	2015	Taken together, our results suggest that the MPK3/MPK6 and ACS2 are part of the Fe starvation-induced ethylene production signaling pathway.	Iron	80-82	mitogen-activated protein kinase 3	Arabidopsis thaliana	45-49
12124425-6	2002	In contrast, IRP1 activity decreased when iron increased up to 20 microm, and then, unexpectedly, increased.	Iron	42-46	aconitase 1	Mus musculus	13-17
12124425-7	2002	IRP1 activity at iron concentrations above 20 microm was functional as it correlated with increased (55) Fe uptake.	Iron	17-21	aconitase 1	Mus musculus	0-4
26579185-9	2015	Taken together, our results suggest that the MPK3/MPK6 and ACS2 are part of the Fe starvation-induced ethylene production signaling pathway.	Iron	80-82	MAP kinase 6	Arabidopsis thaliana	50-54
12124425-7	2002	IRP1 activity at iron concentrations above 20 microm was functional as it correlated with increased (55) Fe uptake.	Iron	105-107	aconitase 1	Mus musculus	0-4
26457760-14	2015	The sum of these observations provides sound evidence that controlled activation of H2O2 at (LX)2Fe(OTf)2 differs from that occurring in biomimetic iron catalysts described to date.	Iron	148-152	POU class 2 homeobox 2	Homo sapiens	100-105
12124425-12	2002	This behavior is probably a consequence of the paradoxical activation of IRP1 at high iron concentrations, a condition that may underlie some processes associated with neuronal degeneration and death.	Iron	86-90	aconitase 1	Mus musculus	73-77
12081573-1	2002	BACKGROUND: DMT1 (Nramp2/DCT1) is the major apical iron transporter in absorptive cells of the duodenum, but also transports transferrin-iron across the membrane of acidified endosomes in peripheral tissues.	Iron	51-55	transferrin	Mus musculus	125-136
25976552-2	2015	In this research, we conjugated an iron-chelating agent, deferasirox, to cationized human serum albumin molecules in order to develop a novel brain delivery system for the management of neurodegenerative disorders due to the significant role of oxidative stress-induced neuronal injury in such diseases.	Iron	35-39	albumin	Rattus norvegicus	90-103
25479470-2	2015	Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin control iron metabolism and are upregulated during renal stress.	Iron	71-75	lipocalin 2	Homo sapiens	0-42
12090619-0	2002	Reactive oxygen intermediates and glutathione regulate the expression of cytosolic ascorbate peroxidase during iron-mediated oxidative stress in bean.	Iron	111-115	L-ascorbate peroxidase 2, cytosolic-like	Nicotiana tabacum	73-103
12090619-2	2002	Cytosolic ascorbate peroxidase (cAPX) is an iron-containing, ROI-detoxifying enzyme induced in response to iron overload or oxidative stress.	Iron	44-48	L-ascorbate peroxidase 2, cytosolic-like	Nicotiana tabacum	0-30
12090619-2	2002	Cytosolic ascorbate peroxidase (cAPX) is an iron-containing, ROI-detoxifying enzyme induced in response to iron overload or oxidative stress.	Iron	107-111	L-ascorbate peroxidase 2, cytosolic-like	Nicotiana tabacum	0-30
25479470-2	2015	Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin control iron metabolism and are upregulated during renal stress.	Iron	71-75	lipocalin 2	Homo sapiens	44-48
26475197-0	2015	Overexpression of Arabidopsis VIT1 increases accumulation of iron in cassava roots and stems.	Iron	61-65	vacuolar iron transporter 1	Arabidopsis thaliana	30-34
11972452-2	2002	TbpA is highly conserved among meningococcal strains, and is thought to be a porin-like integral protein that functions as a gated channel for the passage of iron into the periplasm.	Iron	158-162	transthyretin	Homo sapiens	0-4
11943867-0	2002	Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.	Iron	0-4	transferrin	Mus musculus	24-35
11943867-0	2002	Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.	Iron	0-4	homeostatic iron regulator	Mus musculus	71-74
11943867-3	2002	The function of HFE protein is unknown, but it is hypothesized that it acts in association with beta(2)-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	157-161	homeostatic iron regulator	Mus musculus	16-19
11943867-3	2002	The function of HFE protein is unknown, but it is hypothesized that it acts in association with beta(2)-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	157-161	transferrin	Mus musculus	122-133
11943867-3	2002	The function of HFE protein is unknown, but it is hypothesized that it acts in association with beta(2)-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	157-161	transferrin	Mus musculus	181-192
26475197-3	2015	AtVIT1 was previously found to be involved in mediating vacuolar sequestration of iron, which indicates a potential application for iron biofortification in crop plants.	Iron	82-86	vacuolar iron transporter 1	Arabidopsis thaliana	0-6
11943867-3	2002	The function of HFE protein is unknown, but it is hypothesized that it acts in association with beta(2)-microglobulin and transferrin receptor 1 to regulate iron uptake from plasma transferrin by the duodenum, the proposed mechanism by which body iron levels are sensed.	Iron	247-251	homeostatic iron regulator	Mus musculus	16-19
11943867-4	2002	The aim of this study was to test this hypothesis by comparing clearance of transferrin-bound iron in Hfe knockout (KO) mice with that observed in C57BL/6 control mice.	Iron	94-98	transferrin	Mus musculus	76-87
11943867-4	2002	The aim of this study was to test this hypothesis by comparing clearance of transferrin-bound iron in Hfe knockout (KO) mice with that observed in C57BL/6 control mice.	Iron	94-98	homeostatic iron regulator	Mus musculus	102-105
11943867-9	2002	In both Hfe KO and C57BL/6 mice, plasma iron turnover and iron uptake from plasma transferrin by the duodenum, liver, and kidney correlated positively with plasma iron concentration.	Iron	40-44	homeostatic iron regulator	Mus musculus	8-11
26475197-3	2015	AtVIT1 was previously found to be involved in mediating vacuolar sequestration of iron, which indicates a potential application for iron biofortification in crop plants.	Iron	132-136	vacuolar iron transporter 1	Arabidopsis thaliana	0-6
11943867-9	2002	In both Hfe KO and C57BL/6 mice, plasma iron turnover and iron uptake from plasma transferrin by the duodenum, liver, and kidney correlated positively with plasma iron concentration.	Iron	58-62	transferrin	Mus musculus	82-93
11943867-9	2002	In both Hfe KO and C57BL/6 mice, plasma iron turnover and iron uptake from plasma transferrin by the duodenum, liver, and kidney correlated positively with plasma iron concentration.	Iron	58-62	transferrin	Mus musculus	82-93
26475197-6	2015	Significantly, the expression of AtVIT1 showed a positive correlation with the increase in iron concentration of storage roots.	Iron	91-95	vacuolar iron transporter 1	Arabidopsis thaliana	33-39
11943867-10	2002	However, duodenal iron uptake from plasma transferrin was decreased in the Hfe KO mice compared with the control mice.	Iron	18-22	transferrin	Mus musculus	42-53
26475197-7	2015	Conversely, young leaves of AtVIT1 transgenic plants exhibit characteristics of iron deficiency such as interveinal chlorosis of leaves (yellowing) and lower iron concentration when compared with the wild type plants.	Iron	80-84	vacuolar iron transporter 1	Arabidopsis thaliana	28-34
11943867-10	2002	However, duodenal iron uptake from plasma transferrin was decreased in the Hfe KO mice compared with the control mice.	Iron	18-22	homeostatic iron regulator	Mus musculus	75-78
11943867-12	2002	These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH.	Iron	90-94	homeostatic iron regulator	Mus musculus	39-42
26475197-8	2015	Interestingly, the AtVIT1 transgenic plants showed 4 and 16 times higher values of iron concentration in the young stem and stem base tissues, respectively.	Iron	83-87	vacuolar iron transporter 1	Arabidopsis thaliana	19-25
11943867-12	2002	These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH.	Iron	90-94	transferrin	Mus musculus	72-83
11943867-12	2002	These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH.	Iron	148-152	homeostatic iron regulator	Mus musculus	39-42
26475197-9	2015	AtVIT1 transgenic plants also showed 2-4 times higher values of iron content when compared with wild-type plants, with altered partitioning of iron between source and sink tissues.	Iron	64-68	vacuolar iron transporter 1	Arabidopsis thaliana	0-6
11943867-12	2002	These data support the hypothesis that HFE regulates duodenal uptake of transferrin-bound iron from plasma, and that this mechanism of sensing body iron status, as reflected in plasma iron levels, is impaired in HH.	Iron	148-152	homeostatic iron regulator	Mus musculus	39-42
26475197-9	2015	AtVIT1 transgenic plants also showed 2-4 times higher values of iron content when compared with wild-type plants, with altered partitioning of iron between source and sink tissues.	Iron	143-147	vacuolar iron transporter 1	Arabidopsis thaliana	0-6
12006174-2	2002	HO-1 degrades heme to carbon monoxide (CO), iron, and biliverdin, the latter being reduced to bilirubin by biliverdin reductase.	Iron	44-48	heme oxygenase 1	Rattus norvegicus	0-4
26517988-8	2015	RESULTS: The expression of FTH1 was both dose- and time-dependently induced, and FTH1 expression peaked in response to induction with doxycycline (Dox) at 0.2 mug/ml for 72 h. The induced expression of FTH1 resulted in a significant increase in the transverse relaxation rate of C3H10T1/2-FTH1 cells following iron supplementation.	Iron	310-314	ferritin heavy polypeptide 1	Mus musculus	27-31
11854028-5	2002	Besides having a detoxificating effect by removing Hb from plasma, the CD163-mediated endocytosis of the Hp-Hb complex may represent a major pathway for uptake of iron in the tissue macrophages.	Iron	163-167	CD163 molecule	Homo sapiens	71-76
26517988-8	2015	RESULTS: The expression of FTH1 was both dose- and time-dependently induced, and FTH1 expression peaked in response to induction with doxycycline (Dox) at 0.2 mug/ml for 72 h. The induced expression of FTH1 resulted in a significant increase in the transverse relaxation rate of C3H10T1/2-FTH1 cells following iron supplementation.	Iron	310-314	ferritin heavy polypeptide 1	Mus musculus	81-85
26517988-8	2015	RESULTS: The expression of FTH1 was both dose- and time-dependently induced, and FTH1 expression peaked in response to induction with doxycycline (Dox) at 0.2 mug/ml for 72 h. The induced expression of FTH1 resulted in a significant increase in the transverse relaxation rate of C3H10T1/2-FTH1 cells following iron supplementation.	Iron	310-314	ferritin heavy polypeptide 1	Mus musculus	81-85
26517988-8	2015	RESULTS: The expression of FTH1 was both dose- and time-dependently induced, and FTH1 expression peaked in response to induction with doxycycline (Dox) at 0.2 mug/ml for 72 h. The induced expression of FTH1 resulted in a significant increase in the transverse relaxation rate of C3H10T1/2-FTH1 cells following iron supplementation.	Iron	310-314	ferritin heavy polypeptide 1	Mus musculus	81-85
11927840-0	2002	Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females.	Iron	128-132	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	13-35
11927840-8	2002	Variation in CYP2A6 activity in this sample group was not associated with gender but, interestingly, it did show an inverse association with plasma ferritin; an indicator of body iron stores.	Iron	179-183	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	13-19
11927840-11	2002	These results suggest an increased CYP2A6 expression in subjects who have excessive body iron stores.	Iron	89-93	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	35-41
26517988-9	2015	Prussian blue staining and TEM revealed extensive iron accumulation in C3H10T1/2-FTH1 cells in the presence of Dox.	Iron	50-54	ferritin heavy polypeptide 1	Mus musculus	81-85
11927840-12	2002	Further investigations into the underlying factors that may lead to increased expression of CYP2A6 in association with abnormal body iron stores are currently in progress in our laboratory.	Iron	133-137	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	92-98
26276665-1	2015	Inherited anemias with ineffective erythropoiesis, such as beta-thalassemia, manifest inappropriately low hepcidin production and consequent excessive absorption of dietary iron, leading to iron overload.	Iron	190-194	hepcidin antimicrobial peptide	Mus musculus	106-114
11867720-0	2002	Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.	Iron	35-39	hereditary hemochromatosis protein	Cricetulus griseus	50-53
26275620-0	2015	Human mitochondrial MIA40 (CHCHD4) is a component of the Fe-S cluster export machinery.	Iron	57-61	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	20-25
11867720-4	2002	In agreement with prior studies on other cell lines, we found that overexpression of HFE, without overexpressing beta2M, resulted in a decrease in TfR1dependent iron uptake and in lower iron levels in the cells, as evidenced by ferritin and TfR1 levels measured at steady state.	Iron	161-165	hereditary hemochromatosis protein	Cricetulus griseus	85-88
11867720-4	2002	In agreement with prior studies on other cell lines, we found that overexpression of HFE, without overexpressing beta2M, resulted in a decrease in TfR1dependent iron uptake and in lower iron levels in the cells, as evidenced by ferritin and TfR1 levels measured at steady state.	Iron	161-165	transferrin receptor protein 1	Cricetulus griseus	147-151
11867720-4	2002	In agreement with prior studies on other cell lines, we found that overexpression of HFE, without overexpressing beta2M, resulted in a decrease in TfR1dependent iron uptake and in lower iron levels in the cells, as evidenced by ferritin and TfR1 levels measured at steady state.	Iron	186-190	hereditary hemochromatosis protein	Cricetulus griseus	85-88
11867720-5	2002	However, overexpression of both HFE and beta2M had the reverse effect and resulted in an increase in TfR1-dependent iron uptake and increased iron levels in the cells.	Iron	116-120	hereditary hemochromatosis protein	Cricetulus griseus	32-35
11867720-5	2002	However, overexpression of both HFE and beta2M had the reverse effect and resulted in an increase in TfR1-dependent iron uptake and increased iron levels in the cells.	Iron	116-120	transferrin receptor protein 1	Cricetulus griseus	101-105
26275620-0	2015	Human mitochondrial MIA40 (CHCHD4) is a component of the Fe-S cluster export machinery.	Iron	57-61	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	27-33
11867720-5	2002	However, overexpression of both HFE and beta2M had the reverse effect and resulted in an increase in TfR1-dependent iron uptake and increased iron levels in the cells.	Iron	142-146	hereditary hemochromatosis protein	Cricetulus griseus	32-35
11867720-8	2002	We propose that Chinese hamster ovary cells provide a model to explain the effect of the HFE-beta2M complex in duodenal crypt cells, where the HFE-beta2M complex appears to facilitate the uptake of transferrin-bound iron to sense the level of body iron stores.	Iron	216-220	hereditary hemochromatosis protein	Cricetulus griseus	143-146
26275620-4	2015	hMIA40 is an iron-binding protein with the ability to bind iron in vivo and in vitro.	Iron	13-17	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	0-6
11867720-8	2002	We propose that Chinese hamster ovary cells provide a model to explain the effect of the HFE-beta2M complex in duodenal crypt cells, where the HFE-beta2M complex appears to facilitate the uptake of transferrin-bound iron to sense the level of body iron stores.	Iron	248-252	hereditary hemochromatosis protein	Cricetulus griseus	143-146
26275620-4	2015	hMIA40 is an iron-binding protein with the ability to bind iron in vivo and in vitro.	Iron	59-63	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	0-6
26275620-5	2015	hMIA40 harbours CPC (Cys-Pro-Cys) motif-dependent Fe-S clusters that are sensitive to oxidation.	Iron	50-54	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	0-6
26275620-6	2015	Depletion of hMIA40 results in accumulation of iron in mitochondria concomitant with decreases in the activity and stability of Fe-S-containing cytosolic enzymes.	Iron	47-51	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	13-19
11875007-5	2002	In DBA/2 Hfe-/- mice, increased intestinal iron absorption results from the concomitant up-regulation of the Dcytb, DMT1, and FPN1 messengers.	Iron	43-47	homeostatic iron regulator	Mus musculus	9-12
26275620-6	2015	Depletion of hMIA40 results in accumulation of iron in mitochondria concomitant with decreases in the activity and stability of Fe-S-containing cytosolic enzymes.	Iron	128-132	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	13-19
26275620-8	2015	Taken together, our results demonstrate an indispensable role for hMIA40 for the export of Fe-S clusters from mitochondria.	Iron	91-95	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	66-72
26377631-5	2015	P281L MUTYH was found to be severely compromised both in DNA binding and base excision activity, consistent with the location of this variation in the iron-sulfur cluster (FCL) DNA binding motif of MUTYH.	Iron	151-155	mutY DNA glycosylase	Homo sapiens	6-11
11932491-1	2002	Hephaestin was implicated in mammalian iron homeostasis following its identification as the defective gene in murine sex-linked anaemia.	Iron	39-43	hephaestin	Homo sapiens	0-10
11932491-8	2002	The overall tertiary structure for the hephaestin and the putative residues involved in binding copper and iron appear to be highly conserved between these proteins, which suggests they share the same fold and a conserved function.	Iron	107-111	hephaestin	Homo sapiens	39-49
26377631-5	2015	P281L MUTYH was found to be severely compromised both in DNA binding and base excision activity, consistent with the location of this variation in the iron-sulfur cluster (FCL) DNA binding motif of MUTYH.	Iron	151-155	mutY DNA glycosylase	Homo sapiens	198-203
11911468-0	2002	Electron paramagnetic resonance study reveals a putative iron-sulfur cluster in human rpS3 protein.	Iron	57-61	ribosomal protein S3	Homo sapiens	86-90
26027705-3	2015	Hemojuvelin (HVJ) is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis.	Iron	97-101	hemojuvelin BMP co-receptor	Mus musculus	0-11
11911468-4	2002	E. coli endonuclease III is especially known to have an iron-sulfur cluster as a co-factor.	Iron	56-60	endonuclease III	Escherichia coli	8-24
11911468-5	2002	Here, we tried an electron paramagnetic resonance (EPR) method for the first time to observe a known iron-sulfur cluster signal from E. coli endonuclease III that was previously reported.	Iron	101-105	endonuclease III	Escherichia coli	141-157
11911468-7	2002	As a result, we succeeded in observing a Fe EPR signal that is apparently from an iron-sulfur cluster in the human rpS3 endonuclease.	Iron	41-43	ribosomal protein S3	Homo sapiens	115-119
11911468-7	2002	As a result, we succeeded in observing a Fe EPR signal that is apparently from an iron-sulfur cluster in the human rpS3 endonuclease.	Iron	82-86	ribosomal protein S3	Homo sapiens	115-119
11830506-5	2002	However, when patients with MCV more than 100 fL are excluded, receiver operator curve analysis of CHr, ferritin, transferrin saturation, and MCV demonstrates that CHr has the highest overall sensitivity and specificity of these peripheral blood tests for predicting the absence of bone marrow iron stores.	Iron	294-298	chromate resistance; sulfate transport	Homo sapiens	164-167
26027705-8	2015	These results indicated that HJV(-/-) mice would be a useful model to study cognitive impairment induced by iron overload in brain.	Iron	108-112	hemojuvelin BMP co-receptor	Mus musculus	29-32
26302479-7	2015	In the presence of Ca(II), CP turns on its iron-sequestering function and exhibits subpicomolar affinity for Fe(II).	Iron	43-47	carbonic anhydrase 2	Homo sapiens	19-25
26341526-0	2015	PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?	Iron	53-57	proprotein convertase subtilisin/kexin type 6	Homo sapiens	0-5
11841452-7	2002	Further experiments showed that TRVb-CHO cells, which were stably transfected with TfRDeltaIRE and exposed to either normal medium or DFO, resulted in similar levels of TfR mRNA, but the TfR protein biosynthetic rate increased with iron chelation.	Iron	232-236	transferrin receptor protein 1	Cricetulus griseus	83-86
11841452-8	2002	In summary, expression of TfR in cells placed in an iron-deficient milieu can increase by a mechanism which is independent of the IREs of TfR.	Iron	52-56	transferrin receptor protein 1	Cricetulus griseus	26-29
11815678-6	2002	It is speculated that the site-specific inactivation of TPO might have occurred at the heme-linked histidine residue of the TPO molecule, a critical amino acid for enzyme activity because OH* (vicious free radicals) can be formed at the iron-linked amino acid.	Iron	237-241	thyroid peroxidase	Homo sapiens	56-59
11815678-6	2002	It is speculated that the site-specific inactivation of TPO might have occurred at the heme-linked histidine residue of the TPO molecule, a critical amino acid for enzyme activity because OH* (vicious free radicals) can be formed at the iron-linked amino acid.	Iron	237-241	thyroid peroxidase	Homo sapiens	124-127
26341526-0	2015	PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?	Iron	53-57	proprotein convertase subtilisin/kexin type 6	Homo sapiens	7-12
26341529-0	2015	Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis?	Iron	67-71	proprotein convertase subtilisin/kexin type 6	Homo sapiens	12-17
11801258-1	2002	Heme oxygenase (HO)-1 catalyzes the rate-limiting step in heme degradation releasing iron, carbon monoxide, and biliverdin.	Iron	85-89	heme oxygenase 1	Rattus norvegicus	0-21
26341529-0	2015	Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis?	Iron	67-71	proprotein convertase subtilisin/kexin type 6	Homo sapiens	19-24
26617777-2	2015	Divalent metal transporter1 (DMT1) is the important and well-known plasma membrane transport protein which was proved to be involved in the transport of free ferrous iron in mammals.	Iron	166-170	RoBo-1	Rattus norvegicus	0-27
11772880-1	2002	BACKGROUND: Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO).	Iron	87-91	heme oxygenase 1	Rattus norvegicus	12-28
11772880-1	2002	BACKGROUND: Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO).	Iron	87-91	heme oxygenase 1	Rattus norvegicus	30-34
26617777-2	2015	Divalent metal transporter1 (DMT1) is the important and well-known plasma membrane transport protein which was proved to be involved in the transport of free ferrous iron in mammals.	Iron	166-170	RoBo-1	Rattus norvegicus	29-33
11781385-1	2002	Nramp2 is a widely expressed metal-ion transporter that is involved in dietary iron absorption in the duodenum and iron uptake from transferrin in peripheral tissues.	Iron	115-119	transferrin	Mus musculus	132-143
26617777-13	2015	Expression levels of DMT1 and FPN1 were in parallel with ferrous iron deposition.	Iron	57-69	RoBo-1	Rattus norvegicus	21-25
26617777-18	2015	CONCLUSIONS: DMT1 and FPN1 are positively influenced by ferrous iron status in brain after ICH.	Iron	56-68	RoBo-1	Rattus norvegicus	13-17
26617777-19	2015	DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export.	Iron	24-28	RoBo-1	Rattus norvegicus	0-4
26617777-19	2015	DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export.	Iron	77-81	RoBo-1	Rattus norvegicus	0-4
26301806-3	2015	In this issue of the JCI, Gao and colleagues demonstrate an inverse relationship between adipocyte iron and leptin that is mediated by iron-dependent activation of cAMP-responsive element binding protein (CREB), the transcription factor that represses leptin transcription.	Iron	99-103	cAMP responsive element binding protein 1	Homo sapiens	164-203
11796829-4	2002	Recently, it has been reported that HO-1 is induced in the renal tubular epithelial cells, in which iron is deposited after iron loading, and that this HO-1 induction may be involved in ameliorating iron-induced renal toxicity.	Iron	100-104	heme oxygenase 1	Rattus norvegicus	36-40
11796829-4	2002	Recently, it has been reported that HO-1 is induced in the renal tubular epithelial cells, in which iron is deposited after iron loading, and that this HO-1 induction may be involved in ameliorating iron-induced renal toxicity.	Iron	124-128	heme oxygenase 1	Rattus norvegicus	36-40
26301806-3	2015	In this issue of the JCI, Gao and colleagues demonstrate an inverse relationship between adipocyte iron and leptin that is mediated by iron-dependent activation of cAMP-responsive element binding protein (CREB), the transcription factor that represses leptin transcription.	Iron	99-103	cAMP responsive element binding protein 1	Homo sapiens	205-209
11796829-4	2002	Recently, it has been reported that HO-1 is induced in the renal tubular epithelial cells, in which iron is deposited after iron loading, and that this HO-1 induction may be involved in ameliorating iron-induced renal toxicity.	Iron	124-128	heme oxygenase 1	Rattus norvegicus	36-40
11796829-11	2002	Treatment of angiotensin II-infused rats with an iron chelator, deferoxamine, blocked the abnormal iron deposition in kidneys and also the induced expression of HO-1 and ferritin expression.	Iron	49-53	heme oxygenase 1	Rattus norvegicus	161-165
26301806-3	2015	In this issue of the JCI, Gao and colleagues demonstrate an inverse relationship between adipocyte iron and leptin that is mediated by iron-dependent activation of cAMP-responsive element binding protein (CREB), the transcription factor that represses leptin transcription.	Iron	135-139	cAMP responsive element binding protein 1	Homo sapiens	164-203
11673473-1	2001	Analysis of iron-regulated gene expression in Saccharomyces cerevisiae using cDNA microarrays has identified three putative cell wall proteins that are directly regulated by Aft1p, the major iron-dependent transcription factor in yeast.	Iron	12-16	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	174-179
11739192-1	2001	Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues.	Iron	73-77	transferrin	Mus musculus	49-60
11739192-1	2001	Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues.	Iron	158-162	transferrin	Mus musculus	49-60
11739192-4	2001	Interestingly, iron release from transferrin inside the endosome is normal in mk/mk reticulocytes, suggesting a subsequent defect in Fe(++) transport across the endosomal membrane.	Iron	15-19	transferrin	Mus musculus	33-44
11739192-9	2001	Together, these results provide further evidence that DMT1 plays a central role in iron acquisition via the transferrin cycle in erythroid cells.	Iron	83-87	transferrin	Mus musculus	108-119
26301806-3	2015	In this issue of the JCI, Gao and colleagues demonstrate an inverse relationship between adipocyte iron and leptin that is mediated by iron-dependent activation of cAMP-responsive element binding protein (CREB), the transcription factor that represses leptin transcription.	Iron	135-139	cAMP responsive element binding protein 1	Homo sapiens	205-209
26195809-6	2015	Among the 4 enzyme treatments, hydrolysate from OMAlTr showed the highest iron-chelating and antioxidant activities, while OMP showed higher ACE-inhibitory activity, but lower Fe-chelating activity than the other treatments.	Iron	176-178	olfactory marker protein	Homo sapiens	123-126
11811517-1	2001	Reaction of melatonin with the hypervalent iron centre of oxoferryl hemoglobin, produced in aqueous solution from methemoglobin and H2O2, has been investigated at 37 degrees C and pH 7.4, by absorption spectroscopy.	Iron	43-47	hemoglobin subunit gamma 2	Homo sapiens	114-127
26232490-3	2015	NATURAL RESISTANCE ASSOCIATED-MACROPHAGE PROTEIN3 (AtNRAMP3) and AtNRAMP4 function redundantly in Fe retrieval from vacuoles during germination.	Iron	98-100	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	0-49
11594765-2	2001	TRAP contains a binuclear iron centre which has been shown to generate reactive oxygen species (ROS).	Iron	26-30	acid phosphatase 5, tartrate resistant	Mus musculus	0-4
26232490-3	2015	NATURAL RESISTANCE ASSOCIATED-MACROPHAGE PROTEIN3 (AtNRAMP3) and AtNRAMP4 function redundantly in Fe retrieval from vacuoles during germination.	Iron	98-100	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	51-59
26232490-3	2015	NATURAL RESISTANCE ASSOCIATED-MACROPHAGE PROTEIN3 (AtNRAMP3) and AtNRAMP4 function redundantly in Fe retrieval from vacuoles during germination.	Iron	98-100	natural resistance associated macrophage protein 4	Arabidopsis thaliana	65-73
11580546-1	2001	Fe nanostripes on W(110) are investigated by Kerr magnetometry and spin-polarized scanning tunneling microscopy (SP-STM).	Iron	0-2	sulfotransferase family 1A member 3	Homo sapiens	116-119
26232490-7	2015	The AtVIT1 transporter is involved in Fe influx into vacuoles of endodermal and bundle sheath cells.	Iron	38-40	vacuolar iron transporter 1	Arabidopsis thaliana	4-10
26232490-8	2015	This result establishes a functional link between Fe loading in vacuoles by AtVIT1 and its remobilization by AtNRAMP3 and AtNRAMP4.	Iron	50-52	vacuolar iron transporter 1	Arabidopsis thaliana	76-82
26232490-8	2015	This result establishes a functional link between Fe loading in vacuoles by AtVIT1 and its remobilization by AtNRAMP3 and AtNRAMP4.	Iron	50-52	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	109-117
11535534-11	2001	Expression profiles of TfR2 were different from those of TfR1, suggesting unique functions for TfR2, which may be involved in iron metabolism, hepatocyte function, and erythrocytic differentiation.	Iron	126-130	transferrin receptor 2	Mus musculus	23-27
11535534-11	2001	Expression profiles of TfR2 were different from those of TfR1, suggesting unique functions for TfR2, which may be involved in iron metabolism, hepatocyte function, and erythrocytic differentiation.	Iron	126-130	transferrin receptor 2	Mus musculus	95-99
26232490-8	2015	This result establishes a functional link between Fe loading in vacuoles by AtVIT1 and its remobilization by AtNRAMP3 and AtNRAMP4.	Iron	50-52	natural resistance associated macrophage protein 4	Arabidopsis thaliana	122-130
26232490-9	2015	Moreover, analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.	Iron	34-36	vacuolar iron transporter 1	Arabidopsis thaliana	92-98
11590123-5	2001	This suggests that continuous oxidative damage to iron-sulfur clusters, resulting from hampered superoxide dismutase signaling, is causative of the mitochondrial deficiency and long term mitochondrial iron overload occurring in FRDA.	Iron	50-54	frataxin	Mus musculus	228-232
26232490-9	2015	Moreover, analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.	Iron	34-36	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	100-108
11590123-5	2001	This suggests that continuous oxidative damage to iron-sulfur clusters, resulting from hampered superoxide dismutase signaling, is causative of the mitochondrial deficiency and long term mitochondrial iron overload occurring in FRDA.	Iron	201-205	frataxin	Mus musculus	228-232
26232490-9	2015	Moreover, analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.	Iron	34-36	natural resistance associated macrophage protein 4	Arabidopsis thaliana	114-122
26232490-9	2015	Moreover, analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.	Iron	130-132	vacuolar iron transporter 1	Arabidopsis thaliana	92-98
26232490-9	2015	Moreover, analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.	Iron	130-132	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	100-108
26232490-9	2015	Moreover, analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.	Iron	130-132	natural resistance associated macrophage protein 4	Arabidopsis thaliana	114-122
26005785-10	2015	Overall, this study highlights that sediments impacted by STP discharges can become local hot-spots for Hg methylation due to the combined inputs of i) Hg, ii) organic matter, which fuels bacterial activities and iii) iron, which keeps porewater sulfide concentration low and hence Hg bioavailable.	Iron	218-222	thyroid hormone receptor interactor 10	Homo sapiens	58-61
25840036-2	2015	In this study, a mixed solvent system of di(2-ethylhexyl) phosphate (D2EHPA) and tri-n-butyl phosphate (TBP) diluted with kerosene was used for the selective extraction of vanadium from a hydrochloric acid leaching solution that contained low vanadium concentration with high concentrations of iron and impurities of Ca, Mg, and Al.	Iron	294-298	TATA-box binding protein	Homo sapiens	104-107
26116529-1	2015	Iron chelation is a promising therapeutic strategy for cancer that works, in part, by inducing overexpression of N-myc downstream-regulated gene 1 protein (NDRG1), a known growth inhibitor and metastasis suppressor.	Iron	0-4	N-myc downstream regulated 1	Homo sapiens	113-154
26116529-1	2015	Iron chelation is a promising therapeutic strategy for cancer that works, in part, by inducing overexpression of N-myc downstream-regulated gene 1 protein (NDRG1), a known growth inhibitor and metastasis suppressor.	Iron	0-4	N-myc downstream regulated 1	Homo sapiens	156-161
26116529-3	2015	We investigated the role of RGS19, a regulator of G-protein signaling, in iron chelator-induced NDRG1 overexpression in HeLa cells.	Iron	74-78	N-myc downstream regulated 1	Homo sapiens	96-101
26129708-0	2015	Spin-inversion and spin-selection in the reactions FeO(+) + H2 and Fe(+) + N2O.	Iron	67-72	spindlin 1	Homo sapiens	0-4
26129708-0	2015	Spin-inversion and spin-selection in the reactions FeO(+) + H2 and Fe(+) + N2O.	Iron	67-72	spindlin 1	Homo sapiens	19-23
26129708-2	2015	The reaction of electronic ground state (6)FeO(+) with H2 was found to predominantly produce electronically excited (4)Fe(+) as opposed to electronic ground state (6)Fe(+) corresponding to a spin-allowed reaction.	Iron	166-171	spindlin 1	Homo sapiens	191-195
26149889-0	2015	Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex.	Iron	90-94	transferrin	Mus musculus	119-130
26149889-0	2015	Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex.	Iron	90-94	transferrin	Mus musculus	131-142
26149889-3	2015	Here we conjugated CRT peptide, an iron-mimicry moiety targeting the whole complex of Tf/TfR, to poly(ethylene glycol)-poly(l-lactic-co-glycolic acid) nanoparticles (CRT-NP), to open a new route to overcome such obstacle.	Iron	35-39	transferrin	Mus musculus	86-88
25112680-1	2015	alpha-Lipoic acid-plus (LAP), an amine derivative of alpha-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron.	Iron	153-157	acid phosphatase 2, lysosomal	Rattus norvegicus	0-22
25112680-1	2015	alpha-Lipoic acid-plus (LAP), an amine derivative of alpha-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron.	Iron	153-157	acid phosphatase 2, lysosomal	Rattus norvegicus	24-27
25112680-10	2015	In addition, LA and LAP also reduced oxidative stress and iron deposition in brain tissue.	Iron	58-62	acid phosphatase 2, lysosomal	Rattus norvegicus	20-23
25112680-13	2015	LAP probably exerted neuroprotective effects via targeting lysosomes and chelating intralysosomal iron in EBI post-SAH in rats.	Iron	98-102	acid phosphatase 2, lysosomal	Rattus norvegicus	0-3
25973573-0	2015	Molecular modeling of the binding modes of the iron-sulfur protein to the Jac1 co-chaperone from Saccharomyces cerevisiae by all-atom and coarse-grained approaches.	Iron	47-51	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	74-78
25973573-2	2015	Interaction of Isu1 and Jac1 is a part of the iron-sulfur cluster biogenesis system in mitochondria.	Iron	46-50	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	15-19
25973573-2	2015	Interaction of Isu1 and Jac1 is a part of the iron-sulfur cluster biogenesis system in mitochondria.	Iron	46-50	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	24-28
25904410-1	2015	Hepcidin, a circulatory antimicrobial peptide, is involved in iron homeostasis, inflammation, infection and metabolic signals.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	0-8
25904410-6	2015	The ubiquitous or liver-specific deletion of Hamp1 alleles yielded similar quantitative changes in iron levels in the liver, duodenum, spleen, kidney, heart and brain.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	45-50
26227915-2	2015	Magnetism in the iron-based superconductors is usually a stripe-type spin-density-wave, which breaks the tetragonal symmetry of the lattice, and is known to compete strongly with superconductivity.	Iron	17-21	spindlin 1	Homo sapiens	69-73
26182403-0	2015	The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.	Iron	89-93	ATP binding cassette subfamily E member 1	Homo sapiens	80-84
26182403-4	2015	Depletion of Yae1 or Lto1 results in defective Fe-S maturation of the ribosome-associated ABC protein Rli1, but surprisingly no other tested targets.	Iron	47-51	ATP binding cassette subfamily E member 1	Homo sapiens	102-106
26182403-5	2015	Yae1 and Lto1 facilitate Fe-S cluster assembly on Rli1 in a chain of binding events.	Iron	25-29	ATP binding cassette subfamily E member 1	Homo sapiens	50-54
26185605-5	2015	Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10.	Iron	134-138	interleukin 10	Homo sapiens	273-278
26119317-3	2015	It has been shown that intravenous administration of some iron formulations including saccharated ferric oxide induces hypophosphatemic osteomalacia with high FGF23 levels.	Iron	58-62	fibroblast growth factor 23	Homo sapiens	159-164
25283602-7	2015	A weak negative correlation was determined between anti-CA I antibody titers and ferritin, iron and mean cell volume (MCV) levels (P = 0.013, 0.042, and 0.021, respectively).	Iron	91-95	carbonic anhydrase 1	Homo sapiens	56-60
26044037-0	2015	Identification of Black Bean (Phaseolus vulgaris L.) Polyphenols That Inhibit and Promote Iron Uptake by Caco-2 Cells.	Iron	90-94	brain expressed associated with NEDD4 1	Homo sapiens	24-28
25962551-0	2015	C19orf12 gene mutations in patients with neurodegeneration with brain iron accumulation.	Iron	70-74	chromosome 19 open reading frame 12	Homo sapiens	0-8
25962551-1	2015	A novel subtype of Neurodegeneration with Brain Iron Accumulation (NBIA) recently has been described: mitochondrial membrane protein-associated neurodegeneration (MPAN), caused by mutations of c19orf12 gene.	Iron	48-52	chromosome 19 open reading frame 12	Homo sapiens	193-201
26074074-7	2015	Iron-induced SINE RNA accumulation is due to suppression of DICER1 via sequestration of the co-factor poly(C)-binding protein 2 (PCBP2).	Iron	0-4	dicer 1, ribonuclease type III	Mus musculus	60-66
11435415-6	2001	Here we identify Coq7 as belonging to a family of a di-iron containing oxidases/hydroxylases based on a conserved sequence motif for the iron ligands, supporting a direct function of Coq7 as a hydroxylase.	Iron	55-59	putative monooxygenase CAT5	Saccharomyces cerevisiae S288C	17-21
11435415-6	2001	Here we identify Coq7 as belonging to a family of a di-iron containing oxidases/hydroxylases based on a conserved sequence motif for the iron ligands, supporting a direct function of Coq7 as a hydroxylase.	Iron	55-59	putative monooxygenase CAT5	Saccharomyces cerevisiae S288C	183-187
26074074-7	2015	Iron-induced SINE RNA accumulation is due to suppression of DICER1 via sequestration of the co-factor poly(C)-binding protein 2 (PCBP2).	Iron	0-4	poly(rC) binding protein 2	Mus musculus	129-134
26079688-2	2015	Previous studies suggest that iron status influences phosphate metabolism by modulating proteolytic cleavage of FGF23 into C-terminal fragments.	Iron	30-34	fibroblast growth factor 23	Homo sapiens	112-117
11532431-1	2001	Transferrin is a plasma protein involved in iron delivery to tissues.	Iron	44-48	transferrin	Mus musculus	0-11
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-41	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	95-100
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-41	cytosolic iron-sulfur assembly component 1	Homo sapiens	102-107
11783948-1	2001	A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis.	Iron	135-139	hexokinase 1	Mus musculus	59-80
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-39	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	95-100
11472152-8	2001	Similar analysis for FeM-2 affords removal rate constants for Fe(up)-2, M(up)-2, and Fe(low)-2, and the iron residence probability at each site.	Iron	104-108	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	21-26
25897079-3	2015	We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD.	Iron	37-39	cytosolic iron-sulfur assembly component 1	Homo sapiens	102-107
26016555-5	2015	This review is focused on the structural configuration of iron-containing and iron-free forms of lactoferrin obtained from different sources such as goat, camel and bovine.	Iron	58-62	lactotransferrin	Capra hircus	97-108
11397094-1	2001	Camel lactoferrin is the first protein from the transferrin superfamily that has been found to display the characteristic functions of iron binding and release of lactoferrin as well as transferrin simultaneously.	Iron	135-139	serotransferrin	Camelus bactrianus	48-59
26016555-5	2015	This review is focused on the structural configuration of iron-containing and iron-free forms of lactoferrin obtained from different sources such as goat, camel and bovine.	Iron	78-82	lactotransferrin	Capra hircus	97-108
25765157-2	2015	The disease is caused by severely reduced levels of frataxin, a mitochondrial protein involved in iron metabolism.	Iron	98-102	frataxin	Mus musculus	52-60
11292622-8	2001	The described distribution of DMT-1 protein is in agreement with our previous identification of nephron sites of iron reabsorption, suggesting that DMT-1 provides the molecular mechanism for apical iron entry in the distal nephron but not in the proximal tubule.	Iron	198-202	RoBo-1	Rattus norvegicus	30-35
11292622-8	2001	The described distribution of DMT-1 protein is in agreement with our previous identification of nephron sites of iron reabsorption, suggesting that DMT-1 provides the molecular mechanism for apical iron entry in the distal nephron but not in the proximal tubule.	Iron	198-202	RoBo-1	Rattus norvegicus	148-153
11313312-2	2001	We examined the role of DMT1 and the mucosal iron uptake defect in HFE-knockout mice.	Iron	45-49	homeostatic iron regulator	Mus musculus	67-70
11313312-5	2001	RESULTS: Ferrous iron uptake at 3.5-450 micromol/L was greatly enhanced in HFE-knockouts compared with wild-type, the apparent V(max) for Fe2+ transport being doubled (P &lt; 0.01).	Iron	9-21	homeostatic iron regulator	Mus musculus	75-78
11313312-6	2001	Supplied as Fe3+, uptake was only enhanced in HFE-knockouts at &lt; or =18 micromol/L, when the iron was almost completely converted to Fe2+ by mucosal ferrireductases.	Iron	96-100	homeostatic iron regulator	Mus musculus	46-49
11313312-8	2001	CONCLUSIONS: Disruption of the HFE gene up-regulates functional DMT1 transporters and enhances uptake of ferrous iron by this mechanism; DMT1 also mediates increased uptake after reduction of ferric iron presented at physiological concentrations.	Iron	113-117	homeostatic iron regulator	Mus musculus	31-34
25970748-5	2015	This finding is supported by the results of NAC or DFX treatment, which reduced ROS level by inhibiting NOX4 and p38MAPK and improved the long-term and multi-lineage engrafment of iron overload HSCs after transplantation.	Iron	180-184	NLR family, pyrin domain containing 1A	Mus musculus	44-47
11354283-8	2001	Granulocyte macrophage colony stimulating factor mRNA levels remained unchanged in controls, but were significantly elevated in iron-loaded cells.	Iron	128-132	colony stimulating factor 2	Rattus norvegicus	0-48
25870126-4	2015	Furthermore, through a preferred edge growth route, patterned CuS nanoflakes were synthesized with the combined effect from a copper film seed layer and a passivation layer to further improve FE properties with an Eon of 1.65 V mum(-1) and a beta of 8351.	Iron	192-194	PWWP domain containing 3A, DNA repair factor	Homo sapiens	228-234
25710710-10	2015	GDF11 traps show promising pharmacologic activity in models of both ineffective erythropoiesis and iron-restricted anemia.	Iron	99-103	growth differentiation factor 11	Homo sapiens	0-5
11278167-0	2001	Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload.	Iron	91-95	stearoyl-Coenzyme A desaturase 1	Mus musculus	0-32
11278167-6	2001	This methodology allowed us to identify stearoyl coenzyme A desaturase 1 (SCD1) mRNA overexpression in the liver of iron loaded mice.	Iron	116-120	stearoyl-Coenzyme A desaturase 1	Mus musculus	40-72
11278167-6	2001	This methodology allowed us to identify stearoyl coenzyme A desaturase 1 (SCD1) mRNA overexpression in the liver of iron loaded mice.	Iron	116-120	stearoyl-Coenzyme A desaturase 1	Mus musculus	74-78
11278167-8	2001	In addition, we demonstrated that both SCD1 mRNA expression and activity were increased in another iron overload model in mice obtained by a single iron-dextran subcutaneous injection.	Iron	99-103	stearoyl-Coenzyme A desaturase 1	Mus musculus	39-43
25765152-2	2015	Mammalian complex I (NADH:ubiquinone oxidoreductase) contains 44 different subunits, an FMN and seven iron-sulfur centers.	Iron	102-106	thioredoxin reductase 1	Homo sapiens	37-51
11278167-9	2001	Moreover, we found, in both models, that SCD1 mRNA was not only influenced by the quantity of iron in the liver but also by the duration of iron overload since SCD1 mRNA upregulation was not detected in earlier stages of iron overload.	Iron	94-98	stearoyl-Coenzyme A desaturase 1	Mus musculus	41-45
11278167-9	2001	Moreover, we found, in both models, that SCD1 mRNA was not only influenced by the quantity of iron in the liver but also by the duration of iron overload since SCD1 mRNA upregulation was not detected in earlier stages of iron overload.	Iron	140-144	stearoyl-Coenzyme A desaturase 1	Mus musculus	41-45
11278167-9	2001	Moreover, we found, in both models, that SCD1 mRNA was not only influenced by the quantity of iron in the liver but also by the duration of iron overload since SCD1 mRNA upregulation was not detected in earlier stages of iron overload.	Iron	140-144	stearoyl-Coenzyme A desaturase 1	Mus musculus	41-45
11278167-11	2001	In conclusion, we demonstrated that iron excess in the liver induced both the expression of SCD1 mRNA and its corresponding enzymatic activity.	Iron	36-40	stearoyl-Coenzyme A desaturase 1	Mus musculus	92-96
11278167-13	2001	The fact that the expression and activity of SCD1, an enzyme adding a double bound into saturated fatty acids, are induced in two models of iron overload in mice leads to the conclusion that iron excess in the liver may enhance the biosynthesis of unsaturated fatty acids.	Iron	140-144	stearoyl-Coenzyme A desaturase 1	Mus musculus	45-49
11278167-13	2001	The fact that the expression and activity of SCD1, an enzyme adding a double bound into saturated fatty acids, are induced in two models of iron overload in mice leads to the conclusion that iron excess in the liver may enhance the biosynthesis of unsaturated fatty acids.	Iron	191-195	stearoyl-Coenzyme A desaturase 1	Mus musculus	45-49
25591911-3	2015	In the present study, pretreatment of U373MG human astrocytoma cells with an iron chelator desferrioxamine (DFX) inhibited the expression of CXCL10 induced by a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly IC).	Iron	77-81	C-X-C motif chemokine ligand 10	Homo sapiens	141-147
11223939-3	2001	We have developed an in-plate protocol for the isolation of clones that complement an aft1 mutation in S. cerevisiae that makes cells dependent on iron for growth.	Iron	147-151	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	86-90
25955070-0	2015	Spin-orbit interactions and the nematicity observed in the fe-based superconductors.	Iron	59-61	spindlin 1	Homo sapiens	0-4
25686467-4	2015	To maintain iron homeostasis, the hepcidin-ferroportin (FPN) axis is critically important, and hepcidin is the central governor in guiding dietary iron absorption and iron egress from macrophages.	Iron	147-151	hepcidin antimicrobial peptide	Mus musculus	95-103
25686467-4	2015	To maintain iron homeostasis, the hepcidin-ferroportin (FPN) axis is critically important, and hepcidin is the central governor in guiding dietary iron absorption and iron egress from macrophages.	Iron	147-151	hepcidin antimicrobial peptide	Mus musculus	95-103
25686467-11	2015	Moreover, hepatic hepcidin was downregulated in wild-type mice upon PCB126 administration, coupled with elevated serum iron content as well as reduced hepatic and splenic iron mass.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	18-26
25686467-11	2015	Moreover, hepatic hepcidin was downregulated in wild-type mice upon PCB126 administration, coupled with elevated serum iron content as well as reduced hepatic and splenic iron mass.	Iron	171-175	hepcidin antimicrobial peptide	Mus musculus	18-26
25898169-4	2015	Two functionally interacting Arabidopsis genes, LPR1 (ferroxidase) and PDR2 (P5-type ATPase), are key players in root Pi sensing, which is modified by iron (Fe) availability.	Iron	151-155	Cupredoxin superfamily protein	Arabidopsis thaliana	48-52
25898169-4	2015	Two functionally interacting Arabidopsis genes, LPR1 (ferroxidase) and PDR2 (P5-type ATPase), are key players in root Pi sensing, which is modified by iron (Fe) availability.	Iron	157-159	Cupredoxin superfamily protein	Arabidopsis thaliana	48-52
25898169-5	2015	We show that the LPR1-PDR2 module facilitates, upon Pi limitation, cell-specific apoplastic Fe and callose deposition in the meristem and elongation zone of primary roots.	Iron	92-94	Cupredoxin superfamily protein	Arabidopsis thaliana	17-21
25898169-6	2015	Expression of cell-wall-targeted LPR1 determines the sites of Fe accumulation as well as callose production, which interferes with symplastic communication in the stem cell niche, as demonstrated by impaired SHORT-ROOT movement.	Iron	62-64	Cupredoxin superfamily protein	Arabidopsis thaliana	33-37
25898169-7	2015	Antagonistic interactions of Pi and Fe availability control primary root growth via meristem-specific callose formation, likely triggered by LPR1-dependent redox signaling.	Iron	36-38	Cupredoxin superfamily protein	Arabidopsis thaliana	141-145
25662334-7	2015	Our findings challenge the prevailing role of hepcidin in hypoferremia and suggest that rapid hepcidin-independent ferroportin downregulation in the major sites of iron recycling may represent a first-line response to restrict iron access for numerous pathogens.	Iron	164-168	hepcidin antimicrobial peptide	Mus musculus	94-102
25662334-7	2015	Our findings challenge the prevailing role of hepcidin in hypoferremia and suggest that rapid hepcidin-independent ferroportin downregulation in the major sites of iron recycling may represent a first-line response to restrict iron access for numerous pathogens.	Iron	227-231	hepcidin antimicrobial peptide	Mus musculus	94-102
25552701-11	2015	They also suggest a new strategy to block cellular uptake of transferrin-bound iron, with therapeutic potential for disorders characterized by inappropriate red blood cell production, such as polycythemia vera.	Iron	79-83	transferrin	Mus musculus	61-72
25701385-6	2015	In addition, we determined that RNAi-mediated knock down of MCO1 in A. gambiae affects iron homeostasis.	Iron	87-91	Multicopper oxidase 1	Drosophila melanogaster	60-64
25701385-8	2015	We found that all of the MCO1 orthologs are much better at oxidizing ascorbate than they are at oxidizing ferrous iron or diphenols.	Iron	106-118	Multicopper oxidase 1	Drosophila melanogaster	25-29
25701385-12	2015	The results of this study suggest that MCO1 orthologs function as ascorbate oxidases and influence iron homeostasis through an unknown mechanism.	Iron	99-103	Multicopper oxidase 1	Drosophila melanogaster	39-43
25826316-3	2015	In this study, we investigated the iron-dependent process of heme maturation in Bacillus subtilis and present, for the first time, structural evidence for the physical interaction of a frataxin homologue (Fra), which is suggested to act as a regulatory component as well as an iron chaperone in different cellular pathways, and a ferrochelatase (HemH), which catalyses the final step of heme b biogenesis.	Iron	35-39	ferrochelatase	Homo sapiens	330-344
25826316-5	2015	Hydrogen-deuterium exchange experiments identified the landscape of the Fra/HemH interaction interface and revealed Fra as a specific ferrous iron donor for the ferrochelatase HemH.	Iron	142-146	ferrochelatase	Homo sapiens	161-175
25811611-1	2015	MicroRNA 122 (miR-122) is highly expressed in the liver where it influences diverse biological processes and pathways, including hepatitis C virus replication and metabolism of iron and cholesterol.	Iron	177-181	microRNA 122	Homo sapiens	14-21
25839305-2	2015	With increasing pressure, the Fe ions in the material begin to collapse from a magnetic to nonmagnetic spin state.	Iron	30-32	spindlin 1	Homo sapiens	103-107
25751021-2	2015	Here we show that elevated mtDNA mutagenesis in mice with a proof-reading deficient mtDNA polymerase (PolG) leads to incomplete mitochondrial clearance, with asynchronized iron loading in erythroid precursors, and increased total and free cellular iron content.	Iron	248-252	polymerase (DNA directed), gamma	Mus musculus	102-106
25746420-7	2015	Furthermore, levels of glutamate receptors (both NMDA and AMPA) and nicotinic acetylcholine receptor (nAChR) were significantly elevated in the prefrontal cortex of iron-loaded rats (62% increase in NR1; 70% increase in Glu1A; 115% increase in nAChR).	Iron	165-169	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	68-100
25746420-7	2015	Furthermore, levels of glutamate receptors (both NMDA and AMPA) and nicotinic acetylcholine receptor (nAChR) were significantly elevated in the prefrontal cortex of iron-loaded rats (62% increase in NR1; 70% increase in Glu1A; 115% increase in nAChR).	Iron	165-169	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	102-107
25746420-7	2015	Furthermore, levels of glutamate receptors (both NMDA and AMPA) and nicotinic acetylcholine receptor (nAChR) were significantly elevated in the prefrontal cortex of iron-loaded rats (62% increase in NR1; 70% increase in Glu1A; 115% increase in nAChR).	Iron	165-169	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	244-249
25746420-8	2015	Dietary iron loading also increased the expression of NMDA receptors and nAChR in the hippocampus.	Iron	8-12	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	73-78
25549542-7	2015	Thus, the IRP2 Tg may be a useful tool to probe the roles of iron-induced mitochondrial damages in neurodegeraration research.	Iron	61-65	iron responsive element binding protein 2	Mus musculus	10-14
25501544-1	2015	Hemojuvelin (Hjv) is a membrane protein that controls body iron metabolism by enhancing signaling to hepcidin.	Iron	59-63	hemojuvelin BMP co-receptor	Mus musculus	0-11
25501544-1	2015	Hemojuvelin (Hjv) is a membrane protein that controls body iron metabolism by enhancing signaling to hepcidin.	Iron	59-63	hemojuvelin BMP co-receptor	Mus musculus	13-16
25501544-2	2015	Hjv mutations cause juvenile hemochromatosis, a disease of systemic iron overload.	Iron	68-72	hemojuvelin BMP co-receptor	Mus musculus	0-3
25501544-5	2015	The aim of this study was to investigate the pathological implications of parenchymal iron overload due to Hjv ablation in the fatty liver.	Iron	86-90	hemojuvelin BMP co-receptor	Mus musculus	107-110
25501544-8	2015	As expected, all Hjv(-/-) mice manifested higher serum and hepatic iron and diminished hepcidin levels compared with WT controls.	Iron	67-71	hemojuvelin BMP co-receptor	Mus musculus	17-20
25679229-0	2015	Review: The potential of the common bean (Phaseolus vulgaris) as a vehicle for iron biofortification.	Iron	79-83	brain expressed associated with NEDD4 1	Homo sapiens	36-40
11224665-7	2001	In rats, the divalent metal ion transporter, DMT1, appeared to be important for regulation of both absorption of iron and its movement into the liver.	Iron	113-117	RoBo-1	Rattus norvegicus	45-49
25679229-2	2015	Bean iron concentration is high and can be further increased by biofortification.	Iron	5-9	brain expressed associated with NEDD4 1	Homo sapiens	0-4
25679229-3	2015	A major constraint to bean iron biofortification is low iron absorption, attributed to inhibitory compounds such as phytic acid (PA) and polyphenol(s) (PP).	Iron	27-31	brain expressed associated with NEDD4 1	Homo sapiens	22-26
25679229-3	2015	A major constraint to bean iron biofortification is low iron absorption, attributed to inhibitory compounds such as phytic acid (PA) and polyphenol(s) (PP).	Iron	56-60	brain expressed associated with NEDD4 1	Homo sapiens	22-26
11248704-3	2001	During the reaction cycle, adrenodoxin transfers electrons from the FAD of adrenodoxin reductase to the heme iron of the catalytically active cytochrome P450 (P450scc).	Iron	109-113	ferredoxin reductase	Bos taurus	75-96
25679229-4	2015	We have evaluated the usefulness of the common bean as a vehicle for iron biofortification.	Iron	69-73	brain expressed associated with NEDD4 1	Homo sapiens	47-51
25679229-5	2015	High iron concentrations and wide genetic variability have enabled plant breeders to develop high iron bean varieties (up to 10 mg/100 g).	Iron	5-9	brain expressed associated with NEDD4 1	Homo sapiens	103-107
25679229-5	2015	High iron concentrations and wide genetic variability have enabled plant breeders to develop high iron bean varieties (up to 10 mg/100 g).	Iron	98-102	brain expressed associated with NEDD4 1	Homo sapiens	103-107
25679229-7	2015	Short-term human isotope studies indicate that iron absorption from beans is low, PA is the major inhibitor, and bean PP play a minor role.	Iron	47-51	brain expressed associated with NEDD4 1	Homo sapiens	68-72
11170717-0	2001	Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis.	Iron	124-128	heme oxygenase 1	Rattus norvegicus	0-16
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	85-89	aconitase 1	Mus musculus	112-116
11170717-2	2001	The neurotoxic heme is usually detoxified by the constitutive heme oxygenase-2 (HO-2) and its inducible isoform HO-1(heat shock protein 32) resulting in the formation of biliverdin which becomes reduced to bilirubin, carbon monoxide (CO), and iron.	Iron	243-247	heme oxygenase 1	Rattus norvegicus	112-116
11226304-5	2001	Although the Hfe -/- mice from all three strains demonstrated increased transferrin saturations and liver iron concentrations compared with Hfe +/+ mice, strain differences in severity of iron accumulation were striking.	Iron	106-110	homeostatic iron regulator	Mus musculus	13-16
11226304-6	2001	Targeted disruption of the Hfe gene led to hepatic iron levels in Hfe -/- AKR mice that were 2.5 or 3.6 times higher than those of Hfe -/- C3H or Hfe -/- C57BL/6 mice, respectively.	Iron	51-55	homeostatic iron regulator	Mus musculus	27-30
11226304-8	2001	These observations demonstrate that heritable factors markedly influence iron homeostasis in response to Hfe disruption.	Iron	73-77	homeostatic iron regulator	Mus musculus	105-108
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	85-89	aconitase 1	Mus musculus	177-181
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	147-151	aconitase 1	Mus musculus	85-110
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	147-151	aconitase 1	Mus musculus	112-116
11171977-3	2001	Reduced activity of Jac1 results in a decrease in activity of Fe/S containing mitochondrial proteins and an accumulation of iron in mitochondria.	Iron	124-128	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	20-24
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	147-151	aconitase 1	Mus musculus	177-181
11171977-4	2001	Fe/S enzyme activities remain low in both jac1 and ssq1 mutant mitochondria even if normal mitochondrial iron levels are maintained.	Iron	105-109	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	42-46
25651183-4	2015	Surprisingly, our data indicate that IRP1 activation sustains mitochondrial iron supply and function rather than driving detrimental iron overload.	Iron	76-80	aconitase 1	Mus musculus	37-41
11175792-2	2001	Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC).	Iron	116-120	aconitase 1	Mus musculus	45-49
11175792-10	2001	Thus, misregulation of iron metabolism leads to neurodegenerative disease in Ireb2(-/-) mice and may contribute to the pathogenesis of comparable human neurodegenerative diseases.	Iron	23-27	iron responsive element binding protein 2	Mus musculus	77-82
25651183-6	2015	Our results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism.	Iron	109-113	aconitase 1	Mus musculus	53-57
25645351-7	2015	Our findings provide an effective method to significantly enhance Tc, Jc, Hirr, and the upper critical field, Hc2, for other families of Fe-based superconductors in the forms of wires/tapes, films, and single crystal and polycrystalline bulks.	Iron	137-139	CYCS pseudogene 38	Homo sapiens	110-113
18968172-5	2001	The Mg(II) and Ca(II) are tolerable with each of them (0.2 mug ml(-1)) up to a concentration level of 0.01-1.0 M. The enrichment factor has been found to be 200 except for Fe and Cu for which the values are 80 and 100, respectively.	Iron	172-174	carbonic anhydrase 2	Homo sapiens	15-21
11155150-6	2001	MIB1 correlated with ALT levels (P=0.0001), hepatitis grading (P=0.02) and tissue iron (P=0.04).	Iron	82-86	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-4
11155150-11	2001	APO and MIB1 are directly related to the extent of liver damage and, from a biochemical point of view, to tissue iron levels.	Iron	113-117	MIB E3 ubiquitin protein ligase 1	Homo sapiens	8-12
25264597-0	2015	Hepatic hepcidin protects against polymicrobial sepsis in mice by regulating host iron status.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	8-16
11158531-7	2001	Taken together, our results suggest that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters.	Iron	168-172	myosin 1	Arabidopsis thaliana	204-209
25264597-1	2015	BACKGROUND: Hepcidin is a master regulator of iron metabolism primarily produced by the liver.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	12-20
25264597-7	2015	RESULTS: Disruption of liver hepcidin expression increased serum iron level (537.8 +- 28.1 mug/dl [mean +- SD] vs. 235.9 +- 62.2 mug/dl; P &lt; 0.05) and reduced iron content in the spleen macrophages at the steady state.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	29-37
11865982-4	2001	The HbSR/CD163 activity may be of quantitative importance for iron uptake in macrophages in general and for some iron-associated pathological processes, e.g. the atherogenesis-promoting oxidation of LDL leading to foam cell formation and apoptosis in the vessel wall.	Iron	62-66	CD163 molecule	Homo sapiens	9-14
25264597-7	2015	RESULTS: Disruption of liver hepcidin expression increased serum iron level (537.8 +- 28.1 mug/dl [mean +- SD] vs. 235.9 +- 62.2 mug/dl; P &lt; 0.05) and reduced iron content in the spleen macrophages at the steady state.	Iron	162-166	hepcidin antimicrobial peptide	Mus musculus	29-37
11865982-4	2001	The HbSR/CD163 activity may be of quantitative importance for iron uptake in macrophages in general and for some iron-associated pathological processes, e.g. the atherogenesis-promoting oxidation of LDL leading to foam cell formation and apoptosis in the vessel wall.	Iron	113-117	CD163 molecule	Homo sapiens	9-14
25264597-9	2015	Treating the hepatic hepcidin knockdown mice with low-iron diet plus iron chelation decreased systemic iron content (serum level: 324.0 +- 67.4 mug/dl vs. 517.4 +- 13.4 mug/dl; P &lt; 0.05) and rescued the mice from lethal sepsis (7-day survival: 36.8% vs. 83.3%; P &lt; 0.01).	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	21-29
11206973-7	2000	These data indicate that recombinant ferritin expression under the control of the maize ubiquitin promoter significantly increases iron levels in vegetative tissues, but that the levels of recombinant ferritin in seeds are not sufficient to increase iron levels significantly over those in the seeds of non-transgenic plants.	Iron	131-135	Fer2	Triticum aestivum	37-45
25264597-9	2015	Treating the hepatic hepcidin knockdown mice with low-iron diet plus iron chelation decreased systemic iron content (serum level: 324.0 +- 67.4 mug/dl vs. 517.4 +- 13.4 mug/dl; P &lt; 0.05) and rescued the mice from lethal sepsis (7-day survival: 36.8% vs. 83.3%; P &lt; 0.01).	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	21-29
25264597-9	2015	Treating the hepatic hepcidin knockdown mice with low-iron diet plus iron chelation decreased systemic iron content (serum level: 324.0 +- 67.4 mug/dl vs. 517.4 +- 13.4 mug/dl; P &lt; 0.05) and rescued the mice from lethal sepsis (7-day survival: 36.8% vs. 83.3%; P &lt; 0.01).	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	21-29
25500022-11	2015	ESC ICAM-1 expression and sICAM-1 secretion were higher after 24 hours of iron overload treatment than in the absence of treatment.	Iron	74-78	intercellular adhesion molecule 1	Homo sapiens	4-10
11035806-3	2000	The homologue of frataxin in yeast, YFH1, is required for cellular respiration and was suggested to regulate mitochondrial iron homeostasis.	Iron	123-127	ferroxidase	Saccharomyces cerevisiae S288C	36-40
25500022-13	2015	CONCLUSION(S): Iron overload activates IKKbeta in ESCs, stimulating the NF-kappaB pathway and increasing ICAM-1 expression and sICAM-1 secretion.	Iron	15-19	intercellular adhesion molecule 1	Homo sapiens	105-111
25385426-7	2015	In terms of responses to iron HIF2alpha is of major importance in key tissues such as the intestine where several iron transporters (Ferroportin, Dcytb) contain HREs within their promoters which bind HIF2alpha.	Iron	25-29	cytochrome b reductase 1	Homo sapiens	146-151
10889193-1	2000	Intracellular iron homeostasis is regulated, in part, by interactions between iron-regulatory proteins (IRP1 and IRP2) and iron-responsive elements (IREs) in ferritin and transferrin receptor mRNAs.	Iron	78-82	iron responsive element binding protein 2	Rattus norvegicus	113-117
25466921-2	2015	The AlkB-related alkane hydroxylases, which are integral membrane non-heme iron enzymes, play a key role in the microbial degradation of many of these hydrocarbons.	Iron	75-79	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	4-8
10996833-2	2000	FMO is an intracellular ferrireductase which may be responsible for the obligatory reduction of ferric to ferrous iron so that reduced iron can be incorporated into heme by ferrochelatase.	Iron	114-118	ferrochelatase	Homo sapiens	173-187
10996833-2	2000	FMO is an intracellular ferrireductase which may be responsible for the obligatory reduction of ferric to ferrous iron so that reduced iron can be incorporated into heme by ferrochelatase.	Iron	135-139	ferrochelatase	Homo sapiens	173-187
25451115-0	2015	Iron administration prevents BDNF decrease and depressive-like behavior following chronic stress.	Iron	0-4	brain-derived neurotrophic factor	Rattus norvegicus	29-33
11039124-1	2000	UNLABELLED: Erythropoietic protoporphyria (EPP, MIM 177000) is an inherited disorder caused by a partial deficiency of ferrochelatase (FECH) which catalyses the chelation of iron into protoporphyrin to form haem.	Iron	174-178	ferrochelatase	Homo sapiens	135-139
25451115-9	2015	Moreover, in the stressed group with moderate iron administration (12 mg/kg), there was a significant elevation of BDNF expression (P&lt;0.05) and decreased immobility behavior time (P&lt;0.05).	Iron	46-50	brain-derived neurotrophic factor	Rattus norvegicus	115-119
25451115-13	2015	Iron administration in a moderate dose can increase these neurotransmitters and BDNF expression.	Iron	0-4	brain-derived neurotrophic factor	Rattus norvegicus	80-84
25301748-8	2015	Furthermore, our findings suggest that the increased nigral iron content exacerbates the oxidative stress levels, promoting apoptosis through the Bcl-2/Bax pathway and the activated caspase-3 pathway in the brain.	Iron	60-64	BCL2-associated X protein	Mus musculus	152-155
11006124-6	2000	Treatment of cells with hypoxia mimics such as cobalt or iron chelators also increased PROXY-1 expression.	Iron	57-61	N-myc downstream regulated 1	Homo sapiens	87-94
25301748-8	2015	Furthermore, our findings suggest that the increased nigral iron content exacerbates the oxidative stress levels, promoting apoptosis through the Bcl-2/Bax pathway and the activated caspase-3 pathway in the brain.	Iron	60-64	caspase 3	Mus musculus	182-191
10930361-3	2000	Genetic inactivation of the yeast frataxin homologue (Yfh1p) results in mitochondrial iron accumulation and hypersensitivity to oxidative stress.	Iron	86-90	ferroxidase	Saccharomyces cerevisiae S288C	54-59
25423099-0	2015	Iron-Catalyzed Regioselective Direct Arylation at the C-3 Position of N-Alkyl-2-pyridone.	Iron	0-4	complement C3	Homo sapiens	54-57
11094978-4	2000	We cloned, sequenced and expressed the corresponding cDNA, which encodes a 39.1 kDa protein containing several sequence motifs conserved in endonuclease III homologues, including an iron-sulfur cluster domain and critical residues at the active site.	Iron	182-186	endonuclease III	Escherichia coli	140-156
10964660-3	2000	Yet, expression of v-ErbA oncoprotein is sufficient to reinduce ferH mRNA utilization at physiological iron concentrations.	Iron	103-107	thyroid hormone receptor alpha	Homo sapiens	21-25
25423099-3	2015	In this report, we demonstrate an easy-to-handle reaction condition with an iron catalyst for the exclusive generation of C-3-arylated pyridone via C-H functionalization.	Iron	76-80	complement C3	Homo sapiens	122-125
10942404-0	2000	Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to erythropoietic protoporphyria.	Iron	17-21	ferrochelatase	Homo sapiens	58-72
10942404-11	2000	The mutations of the codons for 2 of the [2Fe-2S] cluster ligands in patients with EPP supports the importance of the iron-sulfur center for the proper functioning of mammalian FECH and, in at least humans, its absence has a direct clinical impact.	Iron	118-122	ferrochelatase	Homo sapiens	177-181
25179834-2	2015	Ferrochelatase (FECH), the last enzyme of this pathway, inserts iron into protoporphyrin IX (PPIX) to form heme.	Iron	64-68	ferrochelatase	Homo sapiens	0-14
10950931-8	2000	This suggests that the tweety-related proteins could be involved in transport of iron or other divalent cations or alternatively that they may be membrane-bound receptors.	Iron	81-85	tweety	Drosophila melanogaster	23-29
25179834-2	2015	Ferrochelatase (FECH), the last enzyme of this pathway, inserts iron into protoporphyrin IX (PPIX) to form heme.	Iron	64-68	ferrochelatase	Homo sapiens	16-20
25968939-7	2015	Interestingly, ginkgetin could strongly chelate ferrous ion and thereby inhibit the increase of the intracellular labile iron pool through downregulating L-ferritin and upregulating transferrin receptor 1.	Iron	121-125	ferritin light polypeptide 1	Mus musculus	154-164
25427953-3	2015	Murine hfe knockout models have demonstrated that strain background has a strong effect on the severity of iron loading.	Iron	107-111	homeostatic iron regulator	Mus musculus	7-10
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	12-16	transthyretin	Homo sapiens	185-189
10899879-1	2000	Transferrin-iron utilization involves specific binding of human transferrin at the cell surface to what is believed to be a complex of two iron-regulated, transferrin-binding proteins, TbpA and TbpB.	Iron	139-143	transthyretin	Homo sapiens	185-189
25427953-4	2015	We noted that hepatic iron loading in hfe-/- mice occurs primarily over the first postnatal weeks (loading phase) followed by a timeframe of relatively static iron concentrations (plateau phase).	Iron	22-26	homeostatic iron regulator	Mus musculus	38-41
10961168-0	2000	Intestinal beta-carotene 15,15"-dioxygenase activity is markedly enhanced in copper-deficient rats fed on high-iron diets and fructose.	Iron	111-115	beta-carotene oxygenase 1	Rattus norvegicus	11-43
25300398-0	2015	Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice.	Iron	31-35	bone morphogenetic protein 7	Mus musculus	10-14
10961168-1	2000	The purpose of the present work was to examine effects of the Cu-Fe interaction on intestinal beta-carotene 15,15"-dioxygenase activity when a wide range of dietary Fe (deficiency to excess) was used in relation to Cu status of rats.	Iron	65-67	beta-carotene oxygenase 1	Rattus norvegicus	94-126
10961168-1	2000	The purpose of the present work was to examine effects of the Cu-Fe interaction on intestinal beta-carotene 15,15"-dioxygenase activity when a wide range of dietary Fe (deficiency to excess) was used in relation to Cu status of rats.	Iron	165-167	beta-carotene oxygenase 1	Rattus norvegicus	94-126
25300398-1	2015	PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	148-156
25300398-1	2015	PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene.	Iron	158-162	hepcidin antimicrobial peptide	Mus musculus	148-156
10961168-4	2000	The data showed that both Fe concentration and beta-carotene 15,15"-dioxygenase activity in small intestinal mucosa were enhanced with increasing dietary Fe and with Cu deficiency v. Cu adequacy.	Iron	154-156	beta-carotene oxygenase 1	Rattus norvegicus	47-79
25300398-5	2015	RESULTS: In WT mice, 4 h following iron challenge, liver Bmp6 and hepcidin expression were increased, while expression of other Bmps was not affected.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	66-74
10961168-8	2000	In conclusion, the data indicate that beta-carotene 15,15"-dioxygenase activity requires Fe as cofactor in vivo and the enzyme is modulated by the three dietary components: Cu, Fe, and fructose.	Iron	89-91	beta-carotene oxygenase 1	Rattus norvegicus	38-70
10961168-8	2000	In conclusion, the data indicate that beta-carotene 15,15"-dioxygenase activity requires Fe as cofactor in vivo and the enzyme is modulated by the three dietary components: Cu, Fe, and fructose.	Iron	177-179	beta-carotene oxygenase 1	Rattus norvegicus	38-70
25300398-7	2015	In Bmp6-/- mice, iron challenge led to blunted activation of liver Smad signaling and hepcidin expression with a delay of 24 h, associated with increased Bmp5 and Bmp7 expression and increased Bmp2, 4, 5 and 9 expression in the duodenum.	Iron	17-21	hepcidin antimicrobial peptide	Mus musculus	86-94
25300398-7	2015	In Bmp6-/- mice, iron challenge led to blunted activation of liver Smad signaling and hepcidin expression with a delay of 24 h, associated with increased Bmp5 and Bmp7 expression and increased Bmp2, 4, 5 and 9 expression in the duodenum.	Iron	17-21	bone morphogenetic protein 7	Mus musculus	163-167
25300398-9	2015	This was further supported by exogenous BMP7 therapy resulting in an effective hepcidin expression followed by a rapid normalisation of plasma iron values and restored osteopenia in Bmp6-/- mice.	Iron	143-147	bone morphogenetic protein 7	Mus musculus	40-44
10858295-1	2000	Insertion of ferrous iron into protoporphyrin IX is catalyzed by ferrochelatase (EC 4.99.1.1).	Iron	13-25	ferrochelatase	Homo sapiens	65-79
25300398-11	2015	Administration of exogenous BMP7 was effective in correcting the plasma iron level and bone loss, indicating that BMP6 is an essential but not exclusive in vivo regulator of iron homeostasis.	Iron	72-76	bone morphogenetic protein 7	Mus musculus	28-32
25617395-1	2015	Methemoglobin (MetHb) is a form of hemoglobin in which heme iron is oxidized and unable to bind oxygen; its normal basal production is counteracted by an efficient MetHb-reduction pathway.	Iron	60-64	hemoglobin subunit gamma 2	Homo sapiens	0-13
10823926-1	2000	Iron regulatory protein 1 (IRP1) is an RNA binding protein that posttranscriptionally modulates the expression of mRNAs coding for proteins involved in iron metabolism.	Iron	152-156	aconitase 1	Mus musculus	0-25
10823926-1	2000	Iron regulatory protein 1 (IRP1) is an RNA binding protein that posttranscriptionally modulates the expression of mRNAs coding for proteins involved in iron metabolism.	Iron	152-156	aconitase 1	Mus musculus	27-31
25617395-1	2015	Methemoglobin (MetHb) is a form of hemoglobin in which heme iron is oxidized and unable to bind oxygen; its normal basal production is counteracted by an efficient MetHb-reduction pathway.	Iron	60-64	hemoglobin subunit gamma 2	Homo sapiens	15-20
10828045-1	2000	Ferrochelatase, the last enzyme in the heme pathway, chelates protoporphyrin IX and iron to form heme and is mutated in protoporphyria.	Iron	84-88	ferrochelatase	Homo sapiens	0-14
24854990-0	2015	Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron.	Iron	9-13	solute carrier family 25 member 37	Homo sapiens	93-101
10833409-5	2000	Direct comparative experiments showed that mouse and human H-ferritins had the same iron incorporation activity, whereas mouse L-ferritin incorporated iron less efficiently than human L-ferritin.	Iron	151-155	ferritin light polypeptide 1	Mus musculus	127-137
10833409-6	2000	The difference was attributed to the substitution of a residue exposed on the cavity surface (Glu140 --&gt; Lys) in mouse L-ferritin, a hypothesis confirmed by the finding that the mouse L-ferritin mutant Lys140-Glu incorporated iron as efficiently as human L-ferritin.	Iron	229-233	ferritin light polypeptide 1	Mus musculus	122-132
10833409-6	2000	The difference was attributed to the substitution of a residue exposed on the cavity surface (Glu140 --&gt; Lys) in mouse L-ferritin, a hypothesis confirmed by the finding that the mouse L-ferritin mutant Lys140-Glu incorporated iron as efficiently as human L-ferritin.	Iron	229-233	ferritin light polypeptide 1	Mus musculus	187-197
25325718-0	2015	Speciation of iron in mouse liver during development, iron deficiency, IRP2 deletion and inflammatory hepatitis.	Iron	14-18	iron responsive element binding protein 2	Mus musculus	71-75
10833409-6	2000	The difference was attributed to the substitution of a residue exposed on the cavity surface (Glu140 --&gt; Lys) in mouse L-ferritin, a hypothesis confirmed by the finding that the mouse L-ferritin mutant Lys140-Glu incorporated iron as efficiently as human L-ferritin.	Iron	229-233	ferritin light polypeptide 1	Mus musculus	187-197
10802175-4	2000	A strain possessing a disruption in the ARN1 gene was unable to transport ferrirubin, ferrirhodin and also ferrichrome A, indicating that the encoded transporter recognizes anhydromevalonyl and the structurally-related methylglutaconyl side-chains surrounding the iron center.	Iron	264-268	siderophore transporter	Saccharomyces cerevisiae S288C	40-44
25325718-15	2015	Livers from mice with inflammatory hepatitis and from IRP2(-/-) mice hyper-accumulated Fe.	Iron	87-89	iron responsive element binding protein 2	Mus musculus	54-58
10769179-0	2000	Involvement of NRAMP1 from Arabidopsis thaliana in iron transport.	Iron	51-55	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	15-21
26812811-9	2015	Administering Yarrowia lipolytica yeast to turkey hens may stimulate the enzymatic response of the antioxidant system (e.g. increasing catalase activity), mainly by increasing the concentration of iron in the plasma.	Iron	197-201	catalase	Gallus gallus	135-143
10769179-7	2000	AtNramp1 and OsNramp1 are able to complement the fet3fet4 yeast mutant defective both in low- and high-affinity iron transports, whereas AtNramp2 and OsNramp2 fail to do so.	Iron	112-116	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	0-8
10769179-8	2000	In addition, AtNramp1 transcript, but not AtNramp2 transcript, accumulates in response to iron deficiency in roots but not in leaves.	Iron	90-94	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	13-21
10769179-9	2000	Finally, overexpression of AtNramp1 in transgenic A. thaliana plants leads to an increase in plant resistance to toxic iron concentration.	Iron	119-123	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	27-35
26257890-2	2015	NGAL-Siderocalin binds and sequesters the iron loaded bacterial siderophore enterochelin (Ent), defining the protein as an innate immune effector.	Iron	42-46	lipocalin 2	Homo sapiens	0-4
10785444-0	2000	GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide.	Iron	73-77	neurotrophin 4	Rattus norvegicus	9-13
26257890-4	2015	While different catechols have been detected in human urine, they have not been directly purified from a biofluid and demonstrated to ligate iron with NGAL-Siderocalin.	Iron	141-145	lipocalin 2	Homo sapiens	151-155
26257890-5	2015	This paper describes a "natural products" approach to identify small molecules that mediate iron binding to NGAL-Siderocalin.	Iron	92-96	lipocalin 2	Homo sapiens	108-112
27617081-3	2015	In 2002, a landmark paper suggested that Ngal is a bacteriostatic agent which blocks iron acquisition by interacting with a number of bacterial siderophores, especially enterobactin.	Iron	85-89	lipocalin 2	Homo sapiens	41-45
10767347-1	2000	Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is caused in almost all cases by homozygous intronic expansions resulting in the loss of frataxin, a mitochondrial protein conserved through evolution, and involved in mitochondrial iron homeostasis.	Iron	252-256	frataxin	Mus musculus	0-17
10767347-1	2000	Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is caused in almost all cases by homozygous intronic expansions resulting in the loss of frataxin, a mitochondrial protein conserved through evolution, and involved in mitochondrial iron homeostasis.	Iron	252-256	frataxin	Mus musculus	19-23
10791995-3	2000	Compound mutant mice lacking both Hfe and its interacting protein, beta-2 microglobulin (B2m), deposit more tissue iron than mice lacking Hfe only, suggesting that another B2m-interacting protein may be involved in iron regulation.	Iron	115-119	homeostatic iron regulator	Mus musculus	34-37
10791995-3	2000	Compound mutant mice lacking both Hfe and its interacting protein, beta-2 microglobulin (B2m), deposit more tissue iron than mice lacking Hfe only, suggesting that another B2m-interacting protein may be involved in iron regulation.	Iron	215-219	homeostatic iron regulator	Mus musculus	34-37
10791995-4	2000	Hfe knockout mice carrying mutations in the iron transporter DMT1 fail to load iron, indicating that hemochromatosis involves iron flux through DMT1.	Iron	44-48	homeostatic iron regulator	Mus musculus	0-3
27617081-6	2015	Functions of siderocalin include not only bacteriostatic activity but potentially as a mediator of cell growth and differentiation; some of these functions appear to be referable to the holo siderocalin:siderophore:iron complex and recent work suggests that metabolic products may act as mammalian siderophores bound by Ngal.	Iron	215-219	lipocalin 2	Homo sapiens	320-324
10791995-4	2000	Hfe knockout mice carrying mutations in the iron transporter DMT1 fail to load iron, indicating that hemochromatosis involves iron flux through DMT1.	Iron	79-83	homeostatic iron regulator	Mus musculus	0-3
10791995-5	2000	Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well.	Iron	82-86	homeostatic iron regulator	Mus musculus	46-49
25320022-0	2014	Iron(III) located in the dinuclear metallo-beta-lactamase IMP-1 by pseudocontact shifts.	Iron	0-4	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	58-63
10791995-5	2000	Similarly, compound mutants deficient in both Hfe and hephaestin (Heph) show less iron loading than do Hfe knockout mice, indicating that iron absorption in hemochromatosis involves the function of Heph as well.	Iron	138-142	homeostatic iron regulator	Mus musculus	46-49
10791995-6	2000	Finally, compound mutants lacking Hfe and the transferrin receptor accumulate more tissue iron than do mice lacking Hfe alone, consistent with the idea that interaction between these two proteins contributes to the control of normal iron absorption.	Iron	90-94	homeostatic iron regulator	Mus musculus	34-37
10791995-6	2000	Finally, compound mutants lacking Hfe and the transferrin receptor accumulate more tissue iron than do mice lacking Hfe alone, consistent with the idea that interaction between these two proteins contributes to the control of normal iron absorption.	Iron	90-94	transferrin	Mus musculus	46-57
10791995-6	2000	Finally, compound mutants lacking Hfe and the transferrin receptor accumulate more tissue iron than do mice lacking Hfe alone, consistent with the idea that interaction between these two proteins contributes to the control of normal iron absorption.	Iron	233-237	homeostatic iron regulator	Mus musculus	34-37
10791995-6	2000	Finally, compound mutants lacking Hfe and the transferrin receptor accumulate more tissue iron than do mice lacking Hfe alone, consistent with the idea that interaction between these two proteins contributes to the control of normal iron absorption.	Iron	233-237	transferrin	Mus musculus	46-57
11031604-4	2000	We suggest that H3O+ influences the pattern formation and pattern selection in the electrodeposition of iron from FeSO4 solution by either initiating interbranch convection or changing the effective interfacial energy of the deposit and the electrolyte.	Iron	104-108	H3 clustered histone 15	Homo sapiens	16-19
10827256-7	2000	CONCLUSION: Major ABO incompatibility may lead to delayed reticulocyte engraftment, resulting in prolonged transfusion dependency and increased risks of transmission of infection and iron overload.	Iron	183-187	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	18-21
25320022-5	2014	With [GaZn]-IMP-1 as diamagnetic reference, the PCSs unambiguously identified the iron binding site in fresh samples of [FeZn]-IMP-1, even though the two metal centers are less than 3.8 A apart and the iron is high-spin Fe(3+), which produces only small PCSs.	Iron	82-86	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	12-17
10811141-5	2000	Reticulocyte hemoglobin content (CHr) may allow prompt identification of an imbalance between r-HuEPO therapy and iron availability by detecting the presence in reticulocytes of iron-restricted erythropoiesis.	Iron	114-118	chromate resistance; sulfate transport	Homo sapiens	33-36
25320022-5	2014	With [GaZn]-IMP-1 as diamagnetic reference, the PCSs unambiguously identified the iron binding site in fresh samples of [FeZn]-IMP-1, even though the two metal centers are less than 3.8 A apart and the iron is high-spin Fe(3+), which produces only small PCSs.	Iron	82-86	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	127-132
10811141-5	2000	Reticulocyte hemoglobin content (CHr) may allow prompt identification of an imbalance between r-HuEPO therapy and iron availability by detecting the presence in reticulocytes of iron-restricted erythropoiesis.	Iron	178-182	chromate resistance; sulfate transport	Homo sapiens	33-36
25320022-5	2014	With [GaZn]-IMP-1 as diamagnetic reference, the PCSs unambiguously identified the iron binding site in fresh samples of [FeZn]-IMP-1, even though the two metal centers are less than 3.8 A apart and the iron is high-spin Fe(3+), which produces only small PCSs.	Iron	121-123	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	127-132
10811141-6	2000	Diagnosis of simple iron deficiency can also be achieved in a more cost-effective fashion by using CHr in conjunction with the regular complete blood count (CBC), rather than relying on the traditional biochemical parameters of iron metabolism.	Iron	20-24	chromate resistance; sulfate transport	Homo sapiens	99-102
25673336-3	2014	In a mouse model of acute lung injury, they showed that silencing hepcidin (the master regulator of iron metabolism) locally in airway epithelial cells aggravates lung injury by increasing the release of iron from alveolar macrophages, which in turn enhances pulmonary bacterial growth and reduces the macrophages" killing properties.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	66-74
10770282-6	2000	This is through a decrease in iron availability, shown by an increase in IRP2 activity and a reciprocal decrease in conventional protein kinase Cbeta-1 expression.	Iron	30-34	iron responsive element binding protein 2	Mus musculus	73-77
10713071-0	2000	CCC1 suppresses mitochondrial damage in the yeast model of Friedreich"s ataxia by limiting mitochondrial iron accumulation.	Iron	105-109	Ccc1p	Saccharomyces cerevisiae S288C	0-4
25673336-3	2014	In a mouse model of acute lung injury, they showed that silencing hepcidin (the master regulator of iron metabolism) locally in airway epithelial cells aggravates lung injury by increasing the release of iron from alveolar macrophages, which in turn enhances pulmonary bacterial growth and reduces the macrophages" killing properties.	Iron	204-208	hepcidin antimicrobial peptide	Mus musculus	66-74
10713071-1	2000	Deletion of YFH1 in Saccharomyces cerevisiae leads to a loss of respiratory competence due to excessive mitochondrial iron accumulation.	Iron	118-122	ferroxidase	Saccharomyces cerevisiae S288C	12-16
10713071-2	2000	A suppressor screen identified a gene, CCC1, that maintained respiratory function in a Deltayfh1 yeast strain regardless of extracellular iron concentration.	Iron	138-142	Ccc1p	Saccharomyces cerevisiae S288C	39-43
25673336-4	2014	This work underscores that hepcidin acts not only systematically (as a hormone) but also locally for iron metabolism regulation.	Iron	101-105	hepcidin antimicrobial peptide	Mus musculus	27-35
10713071-3	2000	CCC1 expression prevented excessive mitochondrial iron accumulation by limiting mitochondrial iron uptake rather than by increasing mitochondrial iron egress.	Iron	50-54	Ccc1p	Saccharomyces cerevisiae S288C	0-4
25380676-3	2014	The study was conducted to investigate the effects of iron supplementation on the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) and antioxidant status in rats exposed to high-altitude hypoxia environment.	Iron	54-58	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	96-128
10713071-3	2000	CCC1 expression prevented excessive mitochondrial iron accumulation by limiting mitochondrial iron uptake rather than by increasing mitochondrial iron egress.	Iron	94-98	Ccc1p	Saccharomyces cerevisiae S288C	0-4
10713071-3	2000	CCC1 expression prevented excessive mitochondrial iron accumulation by limiting mitochondrial iron uptake rather than by increasing mitochondrial iron egress.	Iron	94-98	Ccc1p	Saccharomyces cerevisiae S288C	0-4
10713071-5	2000	CCC1 expression in wild type cells resulted in increased expression of the high affinity iron transport system composed of FET3 and FTR1, suggesting that intracellular iron is not sensed by the iron-dependent transcription factor Aft1p.	Iron	89-93	Ccc1p	Saccharomyces cerevisiae S288C	0-4
10713071-5	2000	CCC1 expression in wild type cells resulted in increased expression of the high affinity iron transport system composed of FET3 and FTR1, suggesting that intracellular iron is not sensed by the iron-dependent transcription factor Aft1p.	Iron	89-93	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	132-136
25380676-3	2014	The study was conducted to investigate the effects of iron supplementation on the expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) and antioxidant status in rats exposed to high-altitude hypoxia environment.	Iron	54-58	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	130-140
25380676-10	2014	Moreover, iron supplementation at high altitudes affected HIF-1alpha-mediated regulating expression of targeting genes such as EPO and transferrin.	Iron	10-14	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	58-68
10704201-2	2000	Resonance Raman and UV-vis absorption spectroscopies of wild-type and engineered variants of murine ferrochelatase were used to examine the proposed structural mechanism for iron insertion into porphyrin.	Iron	174-178	ferrochelatase	Mus musculus	100-114
18967885-7	2000	The sensor has been satisfactorily applied to speciate iron in synthetic, tap and well waters and wines.	Iron	55-59	nuclear RNA export factor 1	Homo sapiens	74-77
25342699-12	2014	Hepatic hepcidin mRNA expression reflected the nonheme-iron concentrations of the liver and was also comparable for both nano Fe(III)- and FeSO4-supplemented groups, as were iron concentrations in the spleen and duodenum.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	8-16
10648829-4	2000	The G6PD heterozygous subjects have an enzymatic activity which is masked by both the thalassemia trait and the total iron serum deficiency.	Iron	118-122	glucose-6-phosphate dehydrogenase	Homo sapiens	4-8
25121790-9	2014	HO-1, the enzyme that releases iron from heme, was increased in the hippocampus and cortex of hemoglobin-injected animals at 24 hours compared with aCSF-injected controls.	Iron	31-35	heme oxygenase 1	Rattus norvegicus	0-4
10607912-1	2000	Heme oxygenase (HO)-2, the constitutive cognate of oxidative stress inducible HO-1 (HSP32), degrades heme to biliverdin, carbon monoxide, and iron.	Iron	142-146	heme oxygenase 1	Rattus norvegicus	78-82
10607912-1	2000	Heme oxygenase (HO)-2, the constitutive cognate of oxidative stress inducible HO-1 (HSP32), degrades heme to biliverdin, carbon monoxide, and iron.	Iron	142-146	heme oxygenase 1	Rattus norvegicus	84-89
25204651-5	2014	Furthermore, we identified the iron-sulfur cluster scaffold protein IscU as a new substrate of MK2 both in Drosophila cells and in mammalian cells.	Iron	31-35	Iron-sulfur cluster assembly enzyme	Drosophila melanogaster	68-72
10663668-6	2000	In a similar way, the frequency of CD68(+) macrophages was correlated with the amount of Ret40f(+) nucleated erythroid precursors, implicating an involvement of this cell lineage in iron turnover, hemoglobin synthesis, and degradation of the expelled nuclei from normoblasts.	Iron	182-186	CD68 molecule	Homo sapiens	35-39
25174877-9	2014	Changes in mRNA levels of L ferritin and transferrin receptor indicated increased retinal iron levels in i.v.	Iron	90-94	transferrin	Mus musculus	41-52
24722448-3	2014	We found that expression levels of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and adhesion of U937 cells increased in iron-treated human aortic endothelial cells through upregulated NADPH oxidase (NOx) and NF-kappaB signaling.	Iron	170-174	intercellular adhesion molecule 1	Homo sapiens	35-73
10588895-0	1999	Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly.	Iron	84-88	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	25-29
10588895-0	1999	Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly.	Iron	84-88	putative iron-binding protein ISU2	Saccharomyces cerevisiae S288C	34-38
10588895-2	1999	This report focuses on two genes of bakers yeast Saccharomyces cerevisiae, ISU1 and ISU2, which encode homologues to bacterial IscU and NifU, potential iron-binding or cluster-assembly proteins.	Iron	152-156	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	75-79
24722448-3	2014	We found that expression levels of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and adhesion of U937 cells increased in iron-treated human aortic endothelial cells through upregulated NADPH oxidase (NOx) and NF-kappaB signaling.	Iron	170-174	intercellular adhesion molecule 1	Homo sapiens	75-81
10588895-2	1999	This report focuses on two genes of bakers yeast Saccharomyces cerevisiae, ISU1 and ISU2, which encode homologues to bacterial IscU and NifU, potential iron-binding or cluster-assembly proteins.	Iron	152-156	putative iron-binding protein ISU2	Saccharomyces cerevisiae S288C	84-88
10588895-3	1999	As with other yeast genes implicated in Fe/S protein assembly, deletion of either ISU1 or ISU2 results in increased accumulation of iron within the mitochondria, loss of activity of the [4Fe-4S] aconitase enzyme, and suppression of oxidative damage in cells lacking cytosolic copper/zinc superoxide dismutase.	Iron	132-136	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	82-86
10588895-3	1999	As with other yeast genes implicated in Fe/S protein assembly, deletion of either ISU1 or ISU2 results in increased accumulation of iron within the mitochondria, loss of activity of the [4Fe-4S] aconitase enzyme, and suppression of oxidative damage in cells lacking cytosolic copper/zinc superoxide dismutase.	Iron	132-136	putative iron-binding protein ISU2	Saccharomyces cerevisiae S288C	90-94
25389409-7	2014	Following Hb-Hp binding to CD163, cellular internalization of the complex leads to globin and heme metabolism, which is followed by adaptive changes in antioxidant and iron metabolism pathways and macrophage phenotype polarization.	Iron	168-172	CD163 molecule	Homo sapiens	27-32
10588895-4	1999	Both genes are induced in strains expressing an activated allele of Aft1p, the iron-sensing transcription factor, suggesting that they are regulated by the iron status of the cell.	Iron	79-83	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	68-73
10588895-4	1999	Both genes are induced in strains expressing an activated allele of Aft1p, the iron-sensing transcription factor, suggesting that they are regulated by the iron status of the cell.	Iron	156-160	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	68-73
25275535-1	2014	Iron bioavailability in unleavened white and wholegrain bread made from two commercial wheat varieties was assessed by measuring ferritin production in Caco-2 cells.	Iron	0-4	Fer2	Triticum aestivum	129-137
10600893-3	1999	We used a mouse line defective in the major iron transport protein transferrin to investigate the effect of aberrant iron metabolism on the lung"s defense against oxidative injury.	Iron	44-48	transferrin	Mus musculus	67-78
10594646-7	1999	Ca2 + reperfusion injury induced by Ca2 + depletion or H2O2 exposure was blocked by the iron chelator 1, 10-phenanthroline, the NF-kappaB inhibitor pyrrolidinedithiocarbamate and the calcineurin inhibitor FK506.	Iron	88-92	carbonic anhydrase 2	Homo sapiens	0-3
10594646-7	1999	Ca2 + reperfusion injury induced by Ca2 + depletion or H2O2 exposure was blocked by the iron chelator 1, 10-phenanthroline, the NF-kappaB inhibitor pyrrolidinedithiocarbamate and the calcineurin inhibitor FK506.	Iron	88-92	carbonic anhydrase 2	Homo sapiens	36-39
24853299-3	2014	Herein, we describe that lipocalin 2 (LCN2), a mammalian acute-phase protein involved in iron homeostasis, is highly produced in response to Abeta1-42 by choroid plexus epithelial cells and astrocytes, but not by microglia or neurons.	Iron	89-93	lipocalin 2	Homo sapiens	25-36
10630687-2	1999	GSNO and *NO terminate oxidant stress in the brain by (i) inhibiting iron-stimulated hydroxyl radicals formation or the Fenton reaction, (ii) terminating lipid peroxidation, (iii) augmenting the antioxidative potency of glutathione (GSH), (iv) mediating neuroprotective action of brain-derived neurotrophin (BDNF), and (v) inhibiting cysteinyl proteases.	Iron	69-73	brain derived neurotrophic factor	Homo sapiens	294-306
10630687-2	1999	GSNO and *NO terminate oxidant stress in the brain by (i) inhibiting iron-stimulated hydroxyl radicals formation or the Fenton reaction, (ii) terminating lipid peroxidation, (iii) augmenting the antioxidative potency of glutathione (GSH), (iv) mediating neuroprotective action of brain-derived neurotrophin (BDNF), and (v) inhibiting cysteinyl proteases.	Iron	69-73	brain derived neurotrophic factor	Homo sapiens	308-312
24853299-3	2014	Herein, we describe that lipocalin 2 (LCN2), a mammalian acute-phase protein involved in iron homeostasis, is highly produced in response to Abeta1-42 by choroid plexus epithelial cells and astrocytes, but not by microglia or neurons.	Iron	89-93	lipocalin 2	Homo sapiens	38-42
10562540-5	1999	In the ALAS-E-null mutant embryos, erythroid differentiation was arrested, and an abnormal hematopoietic cell fraction emerged that accumulated a large amount of iron diffusely in the cytoplasm.	Iron	162-166	aminolevulinic acid synthase 2, erythroid	Mus musculus	7-13
25203306-2	2014	We use in-protein QM/MM calculations to study the repair of etheno-bridged adenine (epsilonA) by the iron(IV)-oxo species of AlkB enzymes.	Iron	101-105	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	125-129
10562540-7	1999	These results demonstrate that ALAS-E, and hence heme supply, is necessary for differentiation and iron metabolism of erythroid cells.	Iron	99-103	aminolevulinic acid synthase 2, erythroid	Mus musculus	31-37
10556206-0	1999	Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice.	Iron	76-80	transferrin	Mus musculus	25-36
10556206-6	1999	Mouse transferrin injections, in the short term, increased delivery of iron to the marrow and raised hemoglobin levels.	Iron	71-75	transferrin	Mus musculus	6-17
10556206-7	1999	Although mucosal transfer and total iron uptake were reduced at the higher transferrin doses, total uptake was still higher than in controls.	Iron	36-40	transferrin	Mus musculus	75-86
10556206-8	1999	Daily injections of mouse/human transferrin for 3 weeks from weaning, normalized hemoglobin values, and markedly reduced liver iron and intestinal iron absorption values in trf (hpx) animals.	Iron	127-131	transferrin	Mus musculus	32-43
10556206-8	1999	Daily injections of mouse/human transferrin for 3 weeks from weaning, normalized hemoglobin values, and markedly reduced liver iron and intestinal iron absorption values in trf (hpx) animals.	Iron	147-151	transferrin	Mus musculus	32-43
25194615-12	2014	CONCLUSIONS: Our results raise the possibility that IL-10 may play a role in iron homeostasis.	Iron	77-81	interleukin 10	Homo sapiens	52-57
10556206-9	1999	When such daily-injected mice were left for a week to allow transferrin clearance, iron absorption values were significantly enhanced; hemoglobin or hepatic iron levels were, however, not significantly altered.	Iron	83-87	transferrin	Mus musculus	60-71
10556206-10	1999	These data indicate that hyperabsorption of iron in trf (hpx) mice is not solely because of the anemia; transferrin levels per se do affect iron absorption, possibly via a direct effect on the intestinal mucosa.	Iron	140-144	transferrin	Mus musculus	104-115
25259650-0	2014	L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy.	Iron	36-40	ferritin light polypeptide 1	Mus musculus	0-10
10525116-2	1999	Two isozymes, HO-1 and HO-2, oxidatively cleave the substrate to form biliverdin, and the potential cellular messenger, CO; the chelated iron is released as the result of the tetrapyrrole ring opening.	Iron	137-141	heme oxygenase 1	Rattus norvegicus	14-27
25259650-0	2014	L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy.	Iron	36-40	scavenger receptor class A, member 5	Mus musculus	22-28
25259650-2	2014	Transferrin endocytosis is the classical pathway for obtaining iron from the blood circulation in the retina.	Iron	63-67	transferrin	Mus musculus	0-11
25077891-7	2014	And Fe atoms contacting Si atoms have reduced magnetic moments, due to Si-Fe sp-d hybridization interactions.	Iron	4-6	surfactant protein D	Homo sapiens	77-81
11671189-13	1999	At 260 K, both the Fe1 and Fe2 sites are high-spin (HS) with Fe-N bond lengths of 2.161(3) and 2.164(3) A, respectively.	Iron	19-21	spindlin 1	Homo sapiens	46-50
24038040-4	2014	Further analysis showed that the concentration of hepcidin, a hepatic iron-regulating hormone peptide, was reduced in PCLS medium after APAP treatment, resembling the decreased mouse plasma concentrations of hepcidin observed after APAP treatment.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	50-58
10527125-12	1999	Low iron intake, required for the production of pale meat, besides anemia causes metabolic and endocrine adaptations, such as enhanced insulin-dependent glucose utilization and appears to reduce IGF-I responses to GH.	Iron	4-8	IGFI	Bos taurus	195-200
24816174-12	2014	CONCLUSIONS: Hepcidin KO mice represent a novel model of iron overload-related liver diseases and implicate lysosomal injury as a crucial event in iron toxicity.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	13-21
10506583-10	1999	We conclude that there is a beneficial threshold of HO-1 overexpression related to the accumulation of reactive iron released in the degradation of heme.	Iron	112-116	heme oxygenase 1	Rattus norvegicus	52-56
10518045-4	1999	The model system is dependent on challenge with meningococci expressing the transferrin receptor which is obtained by culturing the bacteria under iron restriction.	Iron	147-151	transferrin	Mus musculus	76-87
24816174-12	2014	CONCLUSIONS: Hepcidin KO mice represent a novel model of iron overload-related liver diseases and implicate lysosomal injury as a crucial event in iron toxicity.	Iron	147-151	hepcidin antimicrobial peptide	Mus musculus	13-21
10582332-1	1999	Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, catalyzes the insertion of ferrous iron into protoporphyrin IX.	Iron	97-109	ferrochelatase	Homo sapiens	0-14
24981929-7	2014	The amino acid sequence possesses the conserved domain of typical ferritin H subunits, including seven metal ligands in the ferroxidase center, one iron binding region signature, and a potential bio-mineralization residue (Thy(29)).	Iron	148-152	ferritin heavy chain	Anas platyrhynchos	66-74
10526780-8	1999	Dietary Sc-FOS increase iron absorption and thereby prevented completely this anemia in gastrectomized rats fed the control diet but this effect of Sc-FOS in rats fed heme diet was not complete.	Iron	24-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-14
24711435-4	2014	Serum and urinary NGAL levels, measured by the enzyme-linked immunosorbent assay, and the fractional excretion (FE) of NGAL relative to the FE of proteins (FE NGAL/FE protein ratio) were determined in a cross-sectional (n = 199) and longitudinal (n = 45) cohort of systemic lupus erythematosus (SLE) patients.	Iron	112-114	lipocalin 2	Homo sapiens	119-123
10492444-0	1999	Intensive indoor versus outdoor swine production systems: genotype and supplemental iron effects on blood hemoglobin and selected immune measures in young pigs.	Iron	84-88	HGB	Sus scrofa	106-116
25023283-7	2014	Here, we show that the N-terminal domain of Drosophila melanogaster mtDNA helicase coordinates iron in a 2Fe-2S cluster that enhances protein stability in vitro.	Iron	95-99	mitochondrial DNA helicase	Drosophila melanogaster	68-82
10456324-1	1999	Deletion of the yeast frataxin homologue, YFH1, elicits accumulation of iron in mitochondria and mitochondrial defects.	Iron	72-76	ferroxidase	Saccharomyces cerevisiae S288C	42-46
10456324-2	1999	We report here that in the presence of an iron chelator in the culture medium, the concentration of iron in mitochondria is the same in wild-type and YFH1 deletant strains.	Iron	42-46	ferroxidase	Saccharomyces cerevisiae S288C	150-154
10456324-2	1999	We report here that in the presence of an iron chelator in the culture medium, the concentration of iron in mitochondria is the same in wild-type and YFH1 deletant strains.	Iron	100-104	ferroxidase	Saccharomyces cerevisiae S288C	150-154
10456324-6	1999	Yfh1p might control the synthesis of iron-sulfur clusters in mitochondria.	Iron	37-41	ferroxidase	Saccharomyces cerevisiae S288C	0-5
24933602-2	2014	On the basis that iron can effectively reach the brain by using transferrin receptors for crossing the blood-brain barrier, we propose to investigate if a transferrin-bearing generation 3-polypropylenimine dendrimer would allow the transport of plasmid DNA to the brain after intravenous administration.	Iron	18-22	transferrin	Mus musculus	64-75
10431735-7	1999	Consistent with these findings, the strain of lower virulence (KV-1) showed considerably lower efficiency accumulating radiolabeled iron from transferrin and a low-molecular source [Fe(III)nitrilotriacetic acid] in vitro.	Iron	132-136	transferrin	Mus musculus	142-153
10407142-1	1999	Heme oxygenase catalyzes the regiospecific oxidative degradation of iron protoporphyrin IX (heme) to biliverdin, CO and Fe, utilizing molecular oxygen and electrons donated from the NADPH-cytochrome P-450 reductase.	Iron	120-122	cytochrome p450 oxidoreductase	Rattus norvegicus	182-214
24933602-2	2014	On the basis that iron can effectively reach the brain by using transferrin receptors for crossing the blood-brain barrier, we propose to investigate if a transferrin-bearing generation 3-polypropylenimine dendrimer would allow the transport of plasmid DNA to the brain after intravenous administration.	Iron	18-22	transferrin	Mus musculus	155-166
24570342-6	2014	In addition, our results indicated that enhanced NF-kappaB activity in iAs-HUCs was via LCN2-mediated increase in intracellular iron and reactive oxygen species levels.	Iron	128-132	lipocalin 2	Homo sapiens	88-92
10388567-1	1999	Tartrate-resistant acid phosphatase (TRAP) is a mammalian di-iron- containing enzyme that belongs to the family of purple acid phosphatases (PAP).	Iron	61-65	acid phosphatase 5, tartrate resistant	Rattus norvegicus	37-41
10405761-4	1999	Tyrosine phosphorylation of Bcr by Fes greatly enhanced the binding of Bcr to the SH2 domains of multiple signalling molecules in vitro, including Grb-2, Ras GTPase activating protein, phospholipase C-gamma, the 85,000 M(r) subunit of phosphatidylinositol 3"-kinase, and the Abl tyrosine kinase.	Iron	35-38	BCR activator of RhoGEF and GTPase	Homo sapiens	28-31
24721683-3	2014	NGAL is also an iron trafficking protein, a member of the non-transferrin-bound iron (NTBI) pool and an alternative to the transferrin-mediated iron-delivery pathway.	Iron	16-20	lipocalin 2	Homo sapiens	0-4
10405761-4	1999	Tyrosine phosphorylation of Bcr by Fes greatly enhanced the binding of Bcr to the SH2 domains of multiple signalling molecules in vitro, including Grb-2, Ras GTPase activating protein, phospholipase C-gamma, the 85,000 M(r) subunit of phosphatidylinositol 3"-kinase, and the Abl tyrosine kinase.	Iron	35-38	BCR activator of RhoGEF and GTPase	Homo sapiens	71-74
24721683-3	2014	NGAL is also an iron trafficking protein, a member of the non-transferrin-bound iron (NTBI) pool and an alternative to the transferrin-mediated iron-delivery pathway.	Iron	80-84	lipocalin 2	Homo sapiens	0-4
24721683-3	2014	NGAL is also an iron trafficking protein, a member of the non-transferrin-bound iron (NTBI) pool and an alternative to the transferrin-mediated iron-delivery pathway.	Iron	80-84	lipocalin 2	Homo sapiens	0-4
10438023-28	1999	Results from these experiments indicate that one Fe injection (200 mg) for pigs from sows fed adequate vitamin E will result in adequate growth and hemoglobin concentration with today"s improved genetics.	Iron	49-51	HGB	Sus scrofa	148-158
24721683-5	2014	In this study we investigated the possible association of NGAL with parameters of erythropoiesis, iron metabolism and renal injury in patients with non-transfusion-dependent thalassemia (thalassemia intermedia or TI).	Iron	98-102	lipocalin 2	Homo sapiens	58-62
24721683-14	2014	We postulate that the induction of NGAL in these patients may represent either a survival response, facilitating the survival of the less damaged thalassemic erythroid precursors, or a consequence of the abnormal iron regulation in TI.	Iron	213-217	lipocalin 2	Homo sapiens	35-39
24567067-0	2014	Investigating the role of transferrin in the distribution of iron, manganese, copper, and zinc.	Iron	61-65	transferrin	Mus musculus	26-37
10440210-9	1999	Hepatic IRP2 binding activity was decreased in iron loading and increased in iron deficiency.	Iron	47-51	iron responsive element binding protein 2	Rattus norvegicus	8-12
24567067-2	2014	Integral to our understanding of transferrin, studies in hypotransferrinemic mice, a model of inherited transferrin deficiency, have demonstrated that transferrin is essential for iron delivery for erythropoiesis and in the regulation of expression of hepcidin, a hormone that inhibits macrophage and enterocyte iron efflux.	Iron	180-184	transferrin	Mus musculus	33-44
12025843-0	1999	Energy spectrum of iron nuclei measured inside the MIR space craft using CR-39 track detectors.	Iron	19-23	membrane associated ring-CH-type finger 8	Homo sapiens	51-54
24567067-2	2014	Integral to our understanding of transferrin, studies in hypotransferrinemic mice, a model of inherited transferrin deficiency, have demonstrated that transferrin is essential for iron delivery for erythropoiesis and in the regulation of expression of hepcidin, a hormone that inhibits macrophage and enterocyte iron efflux.	Iron	180-184	hepcidin antimicrobial peptide	Mus musculus	252-260
12025843-6	1999	These particles allow the determination of the low energy part of the spectrum of iron nuclei behind shielding material inside the MIR station.	Iron	82-86	membrane associated ring-CH-type finger 8	Homo sapiens	131-134
24567067-2	2014	Integral to our understanding of transferrin, studies in hypotransferrinemic mice, a model of inherited transferrin deficiency, have demonstrated that transferrin is essential for iron delivery for erythropoiesis and in the regulation of expression of hepcidin, a hormone that inhibits macrophage and enterocyte iron efflux.	Iron	312-316	hepcidin antimicrobial peptide	Mus musculus	252-260
24567067-4	2014	We first assessed metal content in transferrin-rich fractions of wild-type mouse sera and demonstrate that although both iron and manganese cofractionated predominantly with transferrin, the absolute levels of manganese are several orders of magnitude lower than those of iron.	Iron	121-125	transferrin	Mus musculus	174-185
24997736-4	2014	Here we present direct imaging of standing spin waves in individual chains of ferromagnetically coupled S = 2 Fe atoms, assembled one by one on a Cu(2)N surface using a scanning tunnelling microscope.	Iron	110-112	spindlin 1	Homo sapiens	43-47
10499095-3	1999	Before dehydration, &gt; 90% of the iron in hTH1 had Mossbauer parameters typical for high-spin Fe(II) in a six-coordinate environment [isomer shift delta (1.8-77 K) = 1.26-1.24 mm s-1 and quadrupole splitting delta EQ = 2.68 mm s-1].	Iron	36-40	negative elongation factor complex member C/D	Homo sapiens	44-48
10095770-3	1999	Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocytes, and whether the modulation is compatible with the hypothesis that IRPs, in turn, may regulate the expression of iron transport proteins in maturating enterocytes during migration to the villus tips.	Iron	19-23	iron responsive element binding protein 2	Rattus norvegicus	120-125
10095770-3	1999	Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocytes, and whether the modulation is compatible with the hypothesis that IRPs, in turn, may regulate the expression of iron transport proteins in maturating enterocytes during migration to the villus tips.	Iron	84-88	iron responsive element binding protein 2	Rattus norvegicus	120-125
25076907-8	2014	In addition, certain innate resistance genes such as natural resistance associated macrophage protein function (Nramp1) or lipocalin-2 exert part of their antimicrobial activity by controlling host and/or microbial iron homeostasis.	Iron	215-219	lipocalin 2	Homo sapiens	123-134
10095770-3	1999	Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocytes, and whether the modulation is compatible with the hypothesis that IRPs, in turn, may regulate the expression of iron transport proteins in maturating enterocytes during migration to the villus tips.	Iron	84-88	iron responsive element binding protein 2	Rattus norvegicus	120-125
10095770-10	1999	IRP-2 activity remained significantly higher at duodenal villus tips than in crypts, even after 72 h. Intestinal iron absorption capacity decreased with the same delay as IRP-1 activity after intravenous iron administration.	Iron	113-117	iron responsive element binding protein 2	Rattus norvegicus	0-5
10095770-10	1999	IRP-2 activity remained significantly higher at duodenal villus tips than in crypts, even after 72 h. Intestinal iron absorption capacity decreased with the same delay as IRP-1 activity after intravenous iron administration.	Iron	204-208	iron responsive element binding protein 2	Rattus norvegicus	0-5
10095770-12	1999	Luminal administration of iron decreased duodenal IRP-1 and IRP-2 activity at tips and crypts within 2 h. Thus, recently absorbed iron becomes available to cytosolic IRP during its passage through the enterocyte.	Iron	26-30	iron responsive element binding protein 2	Rattus norvegicus	60-65
10095770-12	1999	Luminal administration of iron decreased duodenal IRP-1 and IRP-2 activity at tips and crypts within 2 h. Thus, recently absorbed iron becomes available to cytosolic IRP during its passage through the enterocyte.	Iron	130-134	iron responsive element binding protein 2	Rattus norvegicus	60-65
24750026-0	2014	MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice.	Iron	15-19	ferritin heavy polypeptide 1	Mus musculus	80-84
10711792-9	1999	In the intima, cytosolic ferritin and low-molecular-weight iron with a lysosomal type distribution were found in many CD68-positive macrophages which frequently were surrounded by erythrocytes.	Iron	59-63	CD68 molecule	Homo sapiens	118-122
24750026-8	2014	Loss of Fth1 expression in the intestine could lead to iron over-absorption.	Iron	55-59	ferritin heavy polypeptide 1	Mus musculus	8-12
24797431-3	2014	used quantitative proteomics to identify a cohort of autophagosome-enriched proteins, one of which, nuclear receptor coactivator 4 (NCOA4) was shown to be required for the selective delivery of ferritin to the lysosome, ultimately regulating intracellular iron by autophagic turnover of ferritin, or ferritinophagy.	Iron	256-260	nuclear receptor coactivator 4	Homo sapiens	100-130
10198571-0	1999	Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation--a potential mechanism in atherosclerosis.	Iron	40-44	inactive glutathione hydrolase 2	Homo sapiens	0-29
10198571-11	1999	CONCLUSIONS: Biochemical and histochemical correlates indicate that gamma-GT can promote LDL oxidation by hydrolyzing GSH into more potent iron reductants.	Iron	139-143	inactive glutathione hydrolase 2	Homo sapiens	68-76
24797431-3	2014	used quantitative proteomics to identify a cohort of autophagosome-enriched proteins, one of which, nuclear receptor coactivator 4 (NCOA4) was shown to be required for the selective delivery of ferritin to the lysosome, ultimately regulating intracellular iron by autophagic turnover of ferritin, or ferritinophagy.	Iron	256-260	nuclear receptor coactivator 4	Homo sapiens	132-137
10089831-2	1999	Photosensitivity of target cells may be influenced by mitochondrial iron levels because ferrochelatase-catalyzed insertion of Fe2+ into PpIX converts it to heme, a nonsensitizer.	Iron	68-72	ferrochelatase	Mus musculus	88-102
24867675-7	2014	These findings also suggest a novel mechanism of FGF23 elevation in patients with CKD, who are often iron deficient and demonstrate increased FGF23 production and decreased FGF23 cleavage, consistent with an acquired state that mimics the molecular pathophysiology of ADHR.	Iron	101-105	fibroblast growth factor 23	Homo sapiens	49-54
10091654-5	1999	In this work, conformational changes in CRP induced by cAMP and cGMP binding were mapped and quantitatively analyzed by protein footprinting using iron complexed to diethylenetriaminepentaacetic acid ([Fe-DTPA]2-), iron complexed to ethylenediaminediacetic acid ([Fe-EDDA]), iron complexed to desferrioxamine mesylate ([Fe-HDFO]+), and copper complexed to o-phenanthroline ([(OP)2Cu]+) as proteases.	Iron	147-151	catabolite gene activator protein	Escherichia coli	40-43
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	8-12	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	36-42
9988751-1	1999	Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA-binding proteins that post-transcriptionally regulate the expression of mRNAs that code for proteins involved in the maintenance of iron and energy homeostasis.	Iron	189-193	aconitase 1	Mus musculus	0-32
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	36-42
9988751-1	1999	Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA-binding proteins that post-transcriptionally regulate the expression of mRNAs that code for proteins involved in the maintenance of iron and energy homeostasis.	Iron	189-193	aconitase 1	Mus musculus	34-38
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	36-42
9988751-1	1999	Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA-binding proteins that post-transcriptionally regulate the expression of mRNAs that code for proteins involved in the maintenance of iron and energy homeostasis.	Iron	189-193	iron responsive element binding protein 2	Mus musculus	43-47
24895027-5	2014	Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import.	Iron	88-92	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	36-42
24895027-7	2014	Two lines of evidence confirm that Fra2 dominates basal repression of the Aft1/2 regulons in iron-replete cultures.	Iron	93-97	Bol2p	Saccharomyces cerevisiae S288C	35-39
24895027-7	2014	Two lines of evidence confirm that Fra2 dominates basal repression of the Aft1/2 regulons in iron-replete cultures.	Iron	93-97	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	74-80
24798325-4	2014	Lipocalin 2 is highly expressed in the lung where it exerts immunoregulatory functions dependent on being loaded with siderophore-bound iron (holo-form) or not (apo-form).	Iron	136-140	lipocalin 2	Homo sapiens	0-11
10668440-2	1999	Both C3 and D3 dose-dependently inhibited autoxidation and iron-elevated lipid peroxidation in cortical homogenates.	Iron	59-63	complement C3	Rattus norvegicus	5-14
24798325-5	2014	We demonstrate that similar to lipocalin 2, Bet v 1 is capable of binding iron via catechol-based siderophores.	Iron	74-78	lipocalin 2	Homo sapiens	31-42
24798331-5	2014	This low iron transcriptional response was suppressed by deletion of CCC1, the gene that encodes the vacuolar iron importer.	Iron	9-13	Ccc1p	Saccharomyces cerevisiae S288C	69-73
9914507-6	1999	Analysis of IRP activity in cell lines supplemented with heme or non-heme iron and in livers of iron-loaded and iron-deficient rats indicated that IRP-2 responds more promptly than IRP-1 to modulations of iron content.	Iron	74-78	iron responsive element binding protein 2	Rattus norvegicus	147-152
9914507-6	1999	Analysis of IRP activity in cell lines supplemented with heme or non-heme iron and in livers of iron-loaded and iron-deficient rats indicated that IRP-2 responds more promptly than IRP-1 to modulations of iron content.	Iron	96-100	iron responsive element binding protein 2	Rattus norvegicus	147-152
9914507-6	1999	Analysis of IRP activity in cell lines supplemented with heme or non-heme iron and in livers of iron-loaded and iron-deficient rats indicated that IRP-2 responds more promptly than IRP-1 to modulations of iron content.	Iron	96-100	iron responsive element binding protein 2	Rattus norvegicus	147-152
9914507-6	1999	Analysis of IRP activity in cell lines supplemented with heme or non-heme iron and in livers of iron-loaded and iron-deficient rats indicated that IRP-2 responds more promptly than IRP-1 to modulations of iron content.	Iron	96-100	iron responsive element binding protein 2	Rattus norvegicus	147-152
24798331-5	2014	This low iron transcriptional response was suppressed by deletion of CCC1, the gene that encodes the vacuolar iron importer.	Iron	110-114	Ccc1p	Saccharomyces cerevisiae S288C	69-73
9922163-6	1998	These observations reveal specific details of the interaction between lipoxygenase and a small molecule and raise the possibility that changes in the ligand environment of the iron atom could be a feature of the product activation reaction or the catalytic mechanism.	Iron	160-164	linoleate 9S-lipoxygenase-4	Glycine max	70-82
24798331-6	2014	Measurement of the activity of the iron-dependent gentisate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans expressed in yeast cytosol, showed that changes in Mmt1/2 levels affected cytosol iron concentration even in the absence of Ccc1.	Iron	35-39	Ccc1p	Saccharomyces cerevisiae S288C	239-243
24646470-1	2014	Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	0-8
9851711-0	1998	Site-directed mutagenesis studies of the metal-binding center of the iron-dependent propanediol oxidoreductase from Escherichia coli.	Iron	69-73	oxidoreductase	Escherichia coli	96-110
24646470-1	2014	Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages.	Iron	103-107	hepcidin antimicrobial peptide	Mus musculus	0-8
24574275-0	2014	New insights into Alzheimer"s disease amyloid inhibition: nanosized metallo-supramolecular complexes suppress abeta-induced biosynthesis of heme and iron uptake in PC12 cells.	Iron	149-153	amyloid beta precursor protein	Rattus norvegicus	110-115
9799562-3	1998	The loading of iron into ferritin by the tissue oxidase was inhibited by anti-horse serum ceruloplasmin antibody.	Iron	15-19	ceruloplasmin	Equus caballus	90-103
9799562-4	1998	The stoichiometry of iron oxidation and oxygen consumption during iron loading into ferritin by the tissue-derived oxidase and serum ceruloplasmin were 3.6 +/- 0.2 and 3.9 +/- 0.2, respectively.	Iron	21-25	ceruloplasmin	Equus caballus	133-146
9799562-4	1998	The stoichiometry of iron oxidation and oxygen consumption during iron loading into ferritin by the tissue-derived oxidase and serum ceruloplasmin were 3.6 +/- 0.2 and 3.9 +/- 0.2, respectively.	Iron	66-70	ceruloplasmin	Equus caballus	133-146
9799562-5	1998	These data provide evidence that an enzyme analogous to ceruloplasmin is present on the plasma membrane of horse heart and that this ferroxidase is capable of catalyzing the loading of iron into ferritin.	Iron	185-189	ceruloplasmin	Equus caballus	56-69
24574275-2	2014	Further studies demonstrate that through blocking the heme-binding site, these two compounds can suppress Abeta-induced biosynthesis of heme and iron uptake in PC12 cells.	Iron	145-149	amyloid beta precursor protein	Rattus norvegicus	106-111
24699828-10	2014	DMT1 showed a lower expression in the two iron groups compared with control and diabetic animals, and Hpc showed an increased on its expression in Fe and diabetic/Fe groups.	Iron	147-149	hepcidin antimicrobial peptide	Sus scrofa	102-105
9753639-2	1998	In support of this we find that, when glycated, three different proteins--albumin, gelatin (a soluble collagen fragment) and elastin--all gain a substantial affinity for the transition metals iron and copper.	Iron	192-196	elastin	Homo sapiens	125-132
9726978-4	1998	Four of the homologs (FRE3-FRE6) are specifically iron-regulated through the Aft1 transcription factor.	Iron	50-54	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	77-81
9726978-6	1998	Expression of FRE3-FRE6 is elevated in AFT1-1 cells and attenuated in aft1 null cells, showing that iron modulation occurs through the Aft1 transcriptional activator.	Iron	100-104	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	39-43
9726978-6	1998	Expression of FRE3-FRE6 is elevated in AFT1-1 cells and attenuated in aft1 null cells, showing that iron modulation occurs through the Aft1 transcriptional activator.	Iron	100-104	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	70-74
9726978-6	1998	Expression of FRE3-FRE6 is elevated in AFT1-1 cells and attenuated in aft1 null cells, showing that iron modulation occurs through the Aft1 transcriptional activator.	Iron	100-104	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	135-139
24699828-10	2014	DMT1 showed a lower expression in the two iron groups compared with control and diabetic animals, and Hpc showed an increased on its expression in Fe and diabetic/Fe groups.	Iron	163-165	hepcidin antimicrobial peptide	Sus scrofa	102-105
24754735-3	2014	Here, we report a serendipitous finding that various iron-based magnetic nanoparticles (MNPs) actively augment chemokine receptor CXCR4 expression of bone-marrow-derived mesenchymal stem cells (MSCs).	Iron	53-57	C-X-C motif chemokine receptor 4	Homo sapiens	130-135
9722559-2	1998	Fet3p is proposed to facilitate iron uptake by catalyzing the oxidation of Fe(II) to Fe(III) by O2; in this model, Fe(III) is the substrate for the iron permease, encoded by FTR1.	Iron	32-36	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	174-178
24847265-0	2014	The extrahepatic role of TFR2 in iron homeostasis.	Iron	33-37	transferrin receptor 2	Mus musculus	25-29
9762411-0	1998	Spin trapping for nitric oxide produced in LPS-treated mouse using various new dithiocarbamate iron complexes having substituted proline and serine moiety.	Iron	95-99	spindlin 1	Mus musculus	0-4
9724638-0	1998	Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast.	Iron	61-65	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	69-73
9724638-2	1998	In yeast, iron uptake is homeostatically regulated by the transcription factor encoded by AFT1.	Iron	10-14	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	90-94
9724638-3	1998	Expression of AFT1-1(up), a dominant mutant allele, results in inappropriately high rates of iron uptake, and AFT1-1(up) mutants grow slowly in the presence of high concentrations of iron.	Iron	93-97	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	14-18
24847265-1	2014	Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer TFR1, is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1.	Iron	64-68	transferrin receptor 2	Mus musculus	0-22
9724638-3	1998	Expression of AFT1-1(up), a dominant mutant allele, results in inappropriately high rates of iron uptake, and AFT1-1(up) mutants grow slowly in the presence of high concentrations of iron.	Iron	183-187	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	14-18
9724638-3	1998	Expression of AFT1-1(up), a dominant mutant allele, results in inappropriately high rates of iron uptake, and AFT1-1(up) mutants grow slowly in the presence of high concentrations of iron.	Iron	183-187	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	110-114
9724638-4	1998	We present evidence that when Aft1-1(up) mutants are exposed to iron, they arrest the cell division cycle at the G1 regulatory point Start.	Iron	64-68	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	30-34
9724638-6	1998	The iron-induced arrest is bypassed by overexpression of a mutant G1 cyclin, cln3-2, and expression of the G1-specific cyclins Cln1 and Cln2 is reduced when yeast are exposed to increasing amounts of iron, which may account for the arrest.	Iron	4-8	cyclin CLN2	Saccharomyces cerevisiae S288C	136-140
9724638-6	1998	The iron-induced arrest is bypassed by overexpression of a mutant G1 cyclin, cln3-2, and expression of the G1-specific cyclins Cln1 and Cln2 is reduced when yeast are exposed to increasing amounts of iron, which may account for the arrest.	Iron	200-204	cyclin CLN2	Saccharomyces cerevisiae S288C	136-140
24847265-1	2014	Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer TFR1, is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1.	Iron	64-68	transferrin receptor 2	Mus musculus	24-28
24847265-2	2014	TFR2 gene is mutated in type 3 hemochromatosis, a disorder characterized by iron overload and inability to upregulate hepcidin in response to iron.	Iron	76-80	transferrin receptor 2	Mus musculus	0-4
24847265-2	2014	TFR2 gene is mutated in type 3 hemochromatosis, a disorder characterized by iron overload and inability to upregulate hepcidin in response to iron.	Iron	142-146	transferrin receptor 2	Mus musculus	0-4
9737429-0	1998	Decrease of manganese superoxide dismutase activity in rats fed high levels of iron during colon carcinogenesis.	Iron	79-83	superoxide dismutase 2	Rattus norvegicus	12-42
9737429-5	1998	This study was designed to determine the effects of high dietary lipid and iron levels on MnSOD activity during the early weeks of colon carcinogenesis.	Iron	75-79	superoxide dismutase 2	Rattus norvegicus	90-95
24847265-2	2014	TFR2 gene is mutated in type 3 hemochromatosis, a disorder characterized by iron overload and inability to upregulate hepcidin in response to iron.	Iron	142-146	hepcidin antimicrobial peptide	Mus musculus	118-126
9737429-9	1998	Results showed that iron supplementation increased nuclear aberrations, and decreased manganese concentration and MnSOD activity in colonic mucosa ot control animals.	Iron	20-24	superoxide dismutase 2	Rattus norvegicus	114-119
24847265-6	2014	The iron deficient Tfr2-Tmprss6 double knock out mice have higher red cells count and more severe microcytosis than the liver-specific Tfr2 and Tmprss6 double knock out mice.	Iron	4-8	transferrin receptor 2	Mus musculus	19-23
9737429-10	1998	AOM, and interaction of iron and AOM, also decreased MnSOD activity.	Iron	24-28	superoxide dismutase 2	Rattus norvegicus	53-58
24847269-4	2014	Two forms are linked to mutations in genes directly involved in iron metabolism: neuroferritinopathy, associated to mutations in the FTL gene and aceruloplasminemia, where the ceruloplasmin gene product is defective.	Iron	64-68	ferritin light chain	Homo sapiens	133-136
24727285-1	2014	Temperature dependence of the upper critical magnetic field (Hc2) of single crystalline FeTe0.5Se0.5(Tc = 14.5 K) have been determined by tunnel diode oscillator-based measurements in magnetic fields of up to 55 T and temperatures down to 1.6 K. The Werthamer-Helfand-Hohenberg model accounts for the data for magnetic field applied both parallel (H    ab) and perpendicular (H    c) to the iron conducting plane, in line with a single band superconductivity.	Iron	391-395	CYCS pseudogene 38	Homo sapiens	61-64
9800317-7	1998	The activities of transaminases ASAT and ALAT, alkaline phosphatase, glutamate dehydrogenase and lactate dehydrogenase in serum which are indicative of cell damage were also markedly influenced by moderate dietary iron restriction, in which the enzyme levels in serum increased with intensifying iron depletion.	Iron	214-218	glutamic--pyruvic transaminase	Rattus norvegicus	41-45
9705206-0	1998	Substrates of hexokinase, glucose-6-phosphate dehydrogenase, and glyceraldehyde-3-phosphate dehydrogenase prevent the inhibitory response induced by ascorbic acid/iron and dehydroascorbic acid in rabbit erythrocytes.	Iron	163-167	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	65-105
24759288-0	2014	Spin-correlations and magnetic structure in an Fe monolayer on 5d transition metal surfaces.	Iron	47-49	spindlin 1	Homo sapiens	0-4
9705865-3	1998	Iron is known to induce ferritin synthesis and even in the presence of a low concentration of iron, synthesis of ferritin was enhanced and the activity of IRP-1 was decreased under hypoxia.	Iron	0-4	aconitase 1	Mus musculus	155-160
9705865-3	1998	Iron is known to induce ferritin synthesis and even in the presence of a low concentration of iron, synthesis of ferritin was enhanced and the activity of IRP-1 was decreased under hypoxia.	Iron	94-98	aconitase 1	Mus musculus	155-160
24759288-6	2014	For the Fe/Os(0 0 0 1) system we calculate a very large D/J ratio, correspondingly, a spin spiral ground state.	Iron	8-10	spindlin 1	Homo sapiens	86-90
24812134-1	2014	Coadministration of intravenous (IV) iron improves responses to erythropoiesis-stimulating agents (ESAs) in the treatment of cancer-associated (CAA) and chemotherapy-induced anemia (CIA).	Iron	37-41	teashirt zinc finger homeobox 1	Homo sapiens	144-147
9688655-1	1998	The mechanisms of uptake of non-transferrin-bound iron by human hepatoma cells (HuH7) were investigated using 59Fe-citrate and [14C]citrate.	Iron	50-54	MIR7-3 host gene	Homo sapiens	80-84
9736445-4	1998	It was shown for Photofrin-injected DBA/1 mice that a spleen cell population which expressed high levels of HSA also bound the iron transport protein transferrin.	Iron	127-131	transferrin	Mus musculus	150-161
9657110-1	1998	Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE).	Iron	66-70	iron responsive element binding protein 2	Rattus norvegicus	188-193
24598841-11	2014	GDF15 levels correlated with low hepcidin levels and may contribute to iron overload in this setting.	Iron	71-75	growth differentiation factor 15	Homo sapiens	0-5
9657110-11	1998	Under these circumstances, growth-dependent signals may activate ferritin gene transcription and at the same time hamper the ability of activated IRP-2 to repress translation of ferritin mRNAs, thus preserving for growing liver cells an essential iron-storage compartment.	Iron	247-251	iron responsive element binding protein 2	Rattus norvegicus	146-151
24600694-0	2014	Spin polarization gives rise to Cu precipitation in Fe-matrix.	Iron	52-54	spindlin 1	Homo sapiens	0-4
9621303-2	1998	Although all cells require iron from serum transferrin produced by hepatocytes, cells that create a blood barrier such as Sertoli cells in the testis and choroid plexus epithelium in the brain also express the transferrin gene to provide iron to cells sequestered within the serum-free environment.	Iron	238-242	transferrin	Mus musculus	210-221
24600694-5	2014	Furthermore, the charge density difference also confirmed the weaker bond between Fe and Cu with spin-polarization compared to without spin-polarization, due to the decreased charge between them.	Iron	82-84	spindlin 1	Homo sapiens	97-101
24600694-5	2014	Furthermore, the charge density difference also confirmed the weaker bond between Fe and Cu with spin-polarization compared to without spin-polarization, due to the decreased charge between them.	Iron	82-84	spindlin 1	Homo sapiens	135-139
11670407-0	1998	The Synthesis and Characterization of Two-Dimensional Ferromagnetic Extended Structures Containing High-Spin (S = (5)/(2)) and Low-Spin (S = (1)/(2)) Iron(III) Bridged by Cyanide Groups.	Iron	150-154	spindlin 1	Homo sapiens	131-135
24808863-5	2014	The BMP/HJV/SMAD pathway is the major regulator of hepcidin expression that responds to iron status.	Iron	88-92	hemojuvelin BMP co-receptor	Mus musculus	8-11
9766237-0	1998	Cooperation between the components of the meningococcal transferrin receptor, TbpA and TbpB, in the uptake of transferrin iron by the 37-kDa ferric-binding protein (FbpA).	Iron	122-126	transthyretin	Homo sapiens	78-82
9766237-1	1998	Meningococcal TbpAB complexes TbpA, TbpB and FbpA were purified and used to study their role in the uptake of iron from transferrin to FbpA.	Iron	110-114	transthyretin	Homo sapiens	14-18
9766237-4	1998	FbpA was able to bind iron from transferrin only when TbpAB complexes, TbpA and/or TbpB, were also present during the interaction.	Iron	22-26	transthyretin	Homo sapiens	54-58
24795636-5	2014	We describe how studies of the Belgrade rat have revealed key roles for DMT1 in iron distribution to red blood cells as well as duodenal iron absorption.	Iron	80-84	RoBo-1	Rattus norvegicus	72-76
9576873-2	1998	The soybean LOX-1 was used as a reference compound because its iron ligand sphere is well characterized.	Iron	63-67	protein-lysine 6-oxidase	Oryctolagus cuniculus	12-15
9576873-10	1998	For construction of a structural model of the iron ligand sphere the binding distances extracted from the X-ray spectra were assigned to specific amino acids (His-360, -365, -540, -544 and the C-terminal Ile-662) by molecular modelling using the crystal coordinates of the soybean LOX-1 and of a rabbit 15-LOX-inhibitor complex.	Iron	46-50	protein-lysine 6-oxidase	Oryctolagus cuniculus	281-284
24795636-7	2014	For example, relationships between iron and manganese metabolism have been discerned since both are essential metals transported by DMT1.	Iron	35-39	RoBo-1	Rattus norvegicus	132-136
9516467-2	1998	High affinity iron uptake in Saccharomyces cerevisiae requires a metal reductase, a multicopper ferroxidase, and an iron permease.	Iron	14-18	ferroxidase	Saccharomyces cerevisiae S288C	96-107
9516467-7	1998	The anaerobic repression was reduced in cells expressing an iron-independent form of the trans-activator, Aft1, a protein that regulates the expression of these proteins.	Iron	60-64	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	106-110
24860503-3	2014	HO-1 releases Fe(2+) from heme, and the ferritin heavy chain (FHC) ferroxidase oxidizes Fe(2+) to catalytically inactive Fe(3+) inside ferritin.	Iron	88-90	ferritin heavy polypeptide 1	Mus musculus	62-65
9516467-12	1998	The data suggest a model in which dioxygen directly or indirectly modulates the Fe(III)/Fe(II) ratio in an iron pool linked to Aft1 protein while bipyridyl increases this ratio by chelating Fe(II).	Iron	107-111	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	127-131
24651649-2	2014	We use the model to evaluate the properties of carbon near and on the Sigma5 (3 1 0)[0 0 1] symmetric tilt grain boundary (GB) in iron, and calculations show that a carbon atom lowers the GB energy by 0.29 eV/atom in accordance with DFT.	Iron	130-134	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	70-76
11670316-0	1998	Effect of Carboxamido N Coordination to Iron on the Redox Potential of Low-Spin Non-Heme Iron Centers with N,S Coordination: Relevance to the Iron Site of Nitrile Hydratase.	Iron	40-44	spindlin 1	Homo sapiens	75-79
11670316-0	1998	Effect of Carboxamido N Coordination to Iron on the Redox Potential of Low-Spin Non-Heme Iron Centers with N,S Coordination: Relevance to the Iron Site of Nitrile Hydratase.	Iron	89-93	spindlin 1	Homo sapiens	75-79
11670316-0	1998	Effect of Carboxamido N Coordination to Iron on the Redox Potential of Low-Spin Non-Heme Iron Centers with N,S Coordination: Relevance to the Iron Site of Nitrile Hydratase.	Iron	89-93	spindlin 1	Homo sapiens	75-79
24584481-0	2014	Spin-induced band modifications of graphene through intercalation of magnetic iron atoms.	Iron	78-82	spindlin 1	Homo sapiens	0-4
9521653-4	1998	The spin-lattice relaxation of the reduced form of iron-sulfur center FX was also measured at low temperatures, in FA/FB-depleted PSI membranes.	Iron	51-55	spindlin 1	Homo sapiens	4-8
9559866-8	1998	Glutathione S-transferase (GST) and Mn superoxide dismutase (MnSOD) activities were also significantly increased by iron loading.	Iron	116-120	superoxide dismutase 2	Rattus norvegicus	36-59
9559866-8	1998	Glutathione S-transferase (GST) and Mn superoxide dismutase (MnSOD) activities were also significantly increased by iron loading.	Iron	116-120	superoxide dismutase 2	Rattus norvegicus	61-66
9559866-9	1998	These results demonstrate that iron overload significantly alters the expression of antioxidant enzymes associated with glutathione (GGT and GST) and superoxide metabolism (CuZnSOD and MnSOD).	Iron	31-35	superoxide dismutase 2	Rattus norvegicus	185-190
24584481-1	2014	Intercalation of magnetic iron atoms through graphene formed on the SiC(0001) surface is found to induce significant changes in the electronic properties of graphene due mainly to the Fe-induced asymmetries in charge as well as spin distribution.	Iron	26-30	spindlin 1	Homo sapiens	228-232
24584481-2	2014	From our synchrotron-based photoelectron spectroscopy data together with ab initio calculations, we observe that the Fe-induced charge asymmetry results in the formation of a quasi-free-standing bilayer graphene while the spin asymmetry drives multiple spin-split bands.	Iron	117-119	spindlin 1	Homo sapiens	222-226
24584481-2	2014	From our synchrotron-based photoelectron spectroscopy data together with ab initio calculations, we observe that the Fe-induced charge asymmetry results in the formation of a quasi-free-standing bilayer graphene while the spin asymmetry drives multiple spin-split bands.	Iron	117-119	spindlin 1	Homo sapiens	253-257
9613846-7	1998	The lack of enzymatic activity in the mR1-cR2 complex is attributed to perturbation or elimination of interactions linking the tyrosine radical/dinuclear iron center and the C-terminus within R2.	Iron	154-158	ribonucleotide reductase M2	Mus musculus	43-45
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	Iron	236-240	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	123-129
9478985-6	1998	The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed.	Iron	4-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	227-232
9478985-6	1998	The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed.	Iron	4-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	344-349
9446669-2	1998	In the present study, we showed that stimulation of murine macrophage J774 cells with interferon (IFN)-gamma/lipopolysaccharide (LPS) resulted in a nitric oxide-dependent modulation of the activity of iron regulatory proteins (IRP)-1 and 2, cytoplasmic proteins which, binding to RNA motifs called iron responsive elements (IRE), control ferritin translation.	Iron	201-205	aconitase 1	Mus musculus	227-239
9446669-7	1998	Our findings throw light on the role of IRP-2 showing that: (1) this protein responds to a stimulus in opposite fashion to IRP-1; (2) when abundantly expressed, as in J774 cells, IRP-2 is sufficient to regulate intracellular iron metabolism in living cells; and (3) by allowing increased ferritin synthesis, IRP-2 may play a role in the regulation of iron homeostasis in RE cells during inflammation.	Iron	225-229	iron responsive element binding protein 2	Mus musculus	40-45
9446669-7	1998	Our findings throw light on the role of IRP-2 showing that: (1) this protein responds to a stimulus in opposite fashion to IRP-1; (2) when abundantly expressed, as in J774 cells, IRP-2 is sufficient to regulate intracellular iron metabolism in living cells; and (3) by allowing increased ferritin synthesis, IRP-2 may play a role in the regulation of iron homeostasis in RE cells during inflammation.	Iron	225-229	iron responsive element binding protein 2	Mus musculus	179-184
9446669-7	1998	Our findings throw light on the role of IRP-2 showing that: (1) this protein responds to a stimulus in opposite fashion to IRP-1; (2) when abundantly expressed, as in J774 cells, IRP-2 is sufficient to regulate intracellular iron metabolism in living cells; and (3) by allowing increased ferritin synthesis, IRP-2 may play a role in the regulation of iron homeostasis in RE cells during inflammation.	Iron	225-229	iron responsive element binding protein 2	Mus musculus	179-184
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	Iron	236-240	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	249-255
9446669-7	1998	Our findings throw light on the role of IRP-2 showing that: (1) this protein responds to a stimulus in opposite fashion to IRP-1; (2) when abundantly expressed, as in J774 cells, IRP-2 is sufficient to regulate intracellular iron metabolism in living cells; and (3) by allowing increased ferritin synthesis, IRP-2 may play a role in the regulation of iron homeostasis in RE cells during inflammation.	Iron	351-355	iron responsive element binding protein 2	Mus musculus	40-45
9446669-7	1998	Our findings throw light on the role of IRP-2 showing that: (1) this protein responds to a stimulus in opposite fashion to IRP-1; (2) when abundantly expressed, as in J774 cells, IRP-2 is sufficient to regulate intracellular iron metabolism in living cells; and (3) by allowing increased ferritin synthesis, IRP-2 may play a role in the regulation of iron homeostasis in RE cells during inflammation.	Iron	351-355	iron responsive element binding protein 2	Mus musculus	179-184
9446669-7	1998	Our findings throw light on the role of IRP-2 showing that: (1) this protein responds to a stimulus in opposite fashion to IRP-1; (2) when abundantly expressed, as in J774 cells, IRP-2 is sufficient to regulate intracellular iron metabolism in living cells; and (3) by allowing increased ferritin synthesis, IRP-2 may play a role in the regulation of iron homeostasis in RE cells during inflammation.	Iron	351-355	iron responsive element binding protein 2	Mus musculus	179-184
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	Iron	236-240	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	249-255
24757374-6	2014	However, the expression level of GTP-cyclohydrolase I mRNA in striatum was steadily increased after iron administration.	Iron	100-104	GTP cyclohydrolase 1	Rattus norvegicus	33-53
9523114-2	1998	Homologs of MHC molecules have diverse roles that include presentation of lipid antigens (by CD1), transport of immunoglobulins (by the neonatal Fc receptor), regulation of iron metabolism (by the hemochromatosis gene product, HFE), and deception of the host immune system (by viral homologs).	Iron	173-177	major histocompatibility complex, class I, C	Homo sapiens	12-15
24549117-9	2014	The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl.	Iron	19-23	iron-regulated transporter 1	Arabidopsis thaliana	46-50
9407124-0	1997	Inhibition of the iron-induced ZmFer1 maize ferritin gene expression by antioxidants and serine/threonine phosphatase inhibitors.	Iron	18-22	ferritin-1, chloroplastic	Zea mays	31-37
9407124-4	1997	The ZmFer1 maize ferritin gene is not regulated by ABA, and it is shown in this paper that the corresponding mRNA accumulates in de-rooted maize plantlets and BMS (Black Mexican Sweet) maize cell suspension cultures in response to iron via the oxidative pathway described previously.	Iron	231-235	ferritin-1, chloroplastic	Zea mays	4-10
9407124-8	1997	These data indicate that an okadaic acid-sensitive protein phosphatase activity is involved in the regulation of the ZmFer1 ferritin gene in maize cells, and this activity is required for iron-induced expression of this gene.	Iron	188-192	ferritin-1, chloroplastic	Zea mays	117-123
9434348-4	1997	In this study we demonstrate that proteins encoded by genes previously demonstrated to play critical roles in vacuole assembly for acidification, PEP3, PEP5 and VMA3, are also required for normal copper and iron metal ion homeostasis.	Iron	207-211	H(+)-transporting V0 sector ATPase subunit c	Saccharomyces cerevisiae S288C	161-165
24549117-9	2014	The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl.	Iron	19-23	H[+]-ATPase 2	Arabidopsis thaliana	58-62
24501001-10	2014	Metal quantifications showed that DFO causes a transient iron and zinc uptake at the root level, which is presumably mediated by the metal transporter iron regulated transporter1 (IRT1).	Iron	57-61	iron-regulated transporter 1	Arabidopsis thaliana	180-184
9353031-7	1997	One putative iron-repressible protein was confirmed by Western blot (immunoblot) analysis to be the chlamydial heat shock protein 60 (hsp60).	Iron	13-17	heat shock protein family D (Hsp60) member 1	Homo sapiens	134-139
9353031-8	1997	The enhanced production of this antigen by chlamydiae as a result of iron limitation is of particular importance since there is a well-documented association between chlamydial hsp60 and destructive immunopathological sequelae in infected patients.	Iron	69-73	heat shock protein family D (Hsp60) member 1	Homo sapiens	177-182
9413439-0	1997	The yeast FET5 gene encodes a FET3-related multicopper oxidase implicated in iron transport.	Iron	77-81	ferroxidase FET5	Saccharomyces cerevisiae S288C	10-14
9413439-5	1997	Several observations indicate that Fet5p plays a role analogous to Fet3p in iron transport.	Iron	76-80	ferroxidase FET5	Saccharomyces cerevisiae S288C	35-40
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	15-19	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	53-57
9413439-9	1997	FET5 overexpression increased the rate of iron uptake by a novel uptake system.	Iron	42-46	ferroxidase FET5	Saccharomyces cerevisiae S288C	0-4
9413439-10	1997	Finally, FET5 mRNA levels are regulated by iron and are increased in cells grown in iron-limited media.	Iron	43-47	ferroxidase FET5	Saccharomyces cerevisiae S288C	9-13
9413439-10	1997	Finally, FET5 mRNA levels are regulated by iron and are increased in cells grown in iron-limited media.	Iron	84-88	ferroxidase FET5	Saccharomyces cerevisiae S288C	9-13
9413439-11	1997	These results suggest that Fet5p normally plays a role in the transport of iron.	Iron	75-79	ferroxidase FET5	Saccharomyces cerevisiae S288C	27-32
9511228-5	1997	The expression profile of the putative PHGPX in Arabidopsis under NaCl and Al/Fe treatments, which generate oxidative stress, was analyzed.	Iron	78-80	glutathione peroxidase 6	Arabidopsis thaliana	39-44
9511228-6	1997	Northern blot analysis revealed that the Arabidopsis putative PHGPX mRNA levels were increased about 3 and 4.5 times after exposure to NaCl and Al/Fe, respectively.	Iron	147-149	glutathione peroxidase 6	Arabidopsis thaliana	62-67
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	110-114	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	53-57
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	110-114	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	53-57
24591629-1	2014	The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low.	Iron	110-114	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	53-57
9754329-13	1997	The induction of cutaneous ornithine decarboxylase (ODC) activity and [3H]thymidine incorporation in cutaneous DNA were higher in iron overload groups as compared to normal control animals.	Iron	130-134	ornithine decarboxylase, structural 1	Mus musculus	27-50
9754329-13	1997	The induction of cutaneous ornithine decarboxylase (ODC) activity and [3H]thymidine incorporation in cutaneous DNA were higher in iron overload groups as compared to normal control animals.	Iron	130-134	ornithine decarboxylase, structural 1	Mus musculus	52-55
24509859-2	2014	In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37).	Iron	28-32	solute carrier family 25 member 37	Homo sapiens	70-75
9754329-14	1997	Similar to other oxidant tumor promoters, iron overload enhanced cutaneous lipid peroxidation and xanthine oxidase activity and decreased catalase activity.	Iron	42-46	xanthine dehydrogenase	Mus musculus	98-114
9380695-10	1997	We conclude that IRP1 is not essential for regulation of ferritin or TfR expression by iron and that IRP2 can act as the sole IRE-dependent mediator of cellular iron homeostasis.	Iron	161-165	iron responsive element binding protein 2	Mus musculus	101-105
24509859-2	2014	In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37).	Iron	28-32	solute carrier family 25 member 37	Homo sapiens	77-89
24509859-2	2014	In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37).	Iron	28-32	solute carrier family 25 member 37	Homo sapiens	91-99
24630724-0	2014	Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.	Iron	69-73	Spi-C transcription factor	Homo sapiens	14-19
9292498-3	1997	The regulation of human ferritin L-chain mRNA by iron-responsive elements (IREs) and iron regulatory proteins (IRPs) is subject to this mechanism: translational repression imposed by IRP binding to the IRE of ferritin L-chain mRNA induces poly(A) tail shortening.	Iron	49-53	ferritin light chain	Homo sapiens	24-40
9292498-3	1997	The regulation of human ferritin L-chain mRNA by iron-responsive elements (IREs) and iron regulatory proteins (IRPs) is subject to this mechanism: translational repression imposed by IRP binding to the IRE of ferritin L-chain mRNA induces poly(A) tail shortening.	Iron	49-53	ferritin light chain	Homo sapiens	209-225
24003015-3	2014	We report a patient with HHCS who was misdiagnosed and treated as having hemochromatosis, in whom a heterozygous c.-160A&gt;G mutation was identified in the iron responsive element (IRE) of FTL, causing ferritin synthesis in the absence of iron overload.	Iron	157-161	ferritin light chain	Homo sapiens	190-193
9261182-0	1997	In vitro synthesis of the iron-molybdenum cofactor and maturation of the nif-encoded apodinitrogenase.	Iron	26-30	S100 calcium binding protein A9	Homo sapiens	73-76
9231702-3	1997	Iron in CSF is likely to be representative of that in interstitial fluid of brain.	Iron	0-4	colony stimulating factor 2	Rattus norvegicus	8-11
9231702-15	1997	Within interstitial fluid, transported iron will bind with any unsaturated transferrin synthesized or transported into the brain-CSF system.	Iron	39-43	colony stimulating factor 2	Rattus norvegicus	129-132
9231702-18	1997	Calculations of the amount of iron leaving the system with the bulk flow of CSF indicate that most iron entering brain across the capillary endothelium finally leaves the system with the bulk outflow of CSF through arachnoid villi and other channels.	Iron	30-34	colony stimulating factor 2	Rattus norvegicus	76-79
24003015-3	2014	We report a patient with HHCS who was misdiagnosed and treated as having hemochromatosis, in whom a heterozygous c.-160A&gt;G mutation was identified in the iron responsive element (IRE) of FTL, causing ferritin synthesis in the absence of iron overload.	Iron	240-244	ferritin light chain	Homo sapiens	190-193
9231702-18	1997	Calculations of the amount of iron leaving the system with the bulk flow of CSF indicate that most iron entering brain across the capillary endothelium finally leaves the system with the bulk outflow of CSF through arachnoid villi and other channels.	Iron	30-34	colony stimulating factor 2	Rattus norvegicus	203-206
9231702-18	1997	Calculations of the amount of iron leaving the system with the bulk flow of CSF indicate that most iron entering brain across the capillary endothelium finally leaves the system with the bulk outflow of CSF through arachnoid villi and other channels.	Iron	99-103	colony stimulating factor 2	Rattus norvegicus	76-79
24407677-1	2014	Template-free porous carbon nanofibers embedded by vanadium oxide and decorated with iron nanoparticles (Fe@V-CNF) were prepared in a time and cost-saving manner by combining electrospinning and heat treatment processes.	Iron	85-89	NPHS1 adhesion molecule, nephrin	Homo sapiens	108-113
9245618-0	1997	Sequence analysis of the structural tbpA gene: protein topology and variable regions within neisserial receptors for transferrin iron acquisition.	Iron	129-133	transthyretin	Homo sapiens	36-40
24407677-4	2014	The characterization results revealed that Fe@V-CNF comprised graphitic fibers with well-dispersed distribution of nanosized Fe NPs (~7 nm) along the surface of CNF.	Iron	43-45	NPHS1 adhesion molecule, nephrin	Homo sapiens	46-51
24407677-4	2014	The characterization results revealed that Fe@V-CNF comprised graphitic fibers with well-dispersed distribution of nanosized Fe NPs (~7 nm) along the surface of CNF.	Iron	43-45	NPHS1 adhesion molecule, nephrin	Homo sapiens	48-51
9226182-0	1997	Hereditary hyperferritinemia-cataract syndrome: relationship between phenotypes and specific mutations in the iron-responsive element of ferritin light-chain mRNA.	Iron	110-114	ferritin light chain	Homo sapiens	137-157
24596241-10	2014	Our results reveal a role of SNX1 for the correct trafficking of IRT1 and, thus, for modulating the activity of the iron uptake machinery.	Iron	116-120	sorting nexin 1	Arabidopsis thaliana	29-33
9196065-0	1997	Structure and function of the iron-responsive element from human ferritin L chain mRNA.	Iron	30-34	ferritin light chain	Homo sapiens	65-81
9196065-4	1997	In accordance with previous observations on H form transcripts, the cis-acting regulatory IRE motif of human ferritin L chain mRNA was capable of repressing translation under iron deprivation but permitted mobilization of the transcripts into polysomes following iron repletion in vivo.	Iron	175-179	ferritin light chain	Homo sapiens	109-125
24596241-10	2014	Our results reveal a role of SNX1 for the correct trafficking of IRT1 and, thus, for modulating the activity of the iron uptake machinery.	Iron	116-120	iron-regulated transporter 1	Arabidopsis thaliana	65-69
9196065-4	1997	In accordance with previous observations on H form transcripts, the cis-acting regulatory IRE motif of human ferritin L chain mRNA was capable of repressing translation under iron deprivation but permitted mobilization of the transcripts into polysomes following iron repletion in vivo.	Iron	263-267	ferritin light chain	Homo sapiens	109-125
24577088-0	2014	MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.	Iron	88-92	iron-sulfur cluster assembly enzyme	Mus musculus	126-133
24616700-9	2014	Finally, the protective effect of T lymphocytes was tested by analyzing the patterns of iron accumulation in the T lymphocyte-deficient mouse model Foxn1(nu) before and after reconstitution with T lymphocytes by adoptive transfer.	Iron	88-92	forkhead box N1	Mus musculus	148-153
9207424-0	1997	Increased plasma erythropoietin levels in lambs treated with parenteral iron.	Iron	72-76	erythropoietin	Ovis aries	17-31
9180188-4	1997	CD4 T cells from spleens of iron-overloaded mice were found to produce high levels of IL-4 and IL-10 and low levels of interferon-gamma.	Iron	28-32	CD4 antigen	Mus musculus	0-3
24586779-1	2014	Mutations in the orphan gene C19orf12 were identified as a genetic cause in a subgroup of patients with NBIA, a neurodegenerative disorder characterized by deposits of iron in the basal ganglia.	Iron	168-172	chromosome 19 open reading frame 12	Homo sapiens	29-37
9180188-5	1997	Treatment of iron-overloaded mice with the iron chelator, deferoxamine, resulted in the cure of mice from infection, restored the antifungal effector and immunomodulatory functions of the phagocytic cells, and allowed the occurrence of CD4 Th1 protective antifungal responses.	Iron	13-17	CD4 antigen	Mus musculus	236-239
9180188-5	1997	Treatment of iron-overloaded mice with the iron chelator, deferoxamine, resulted in the cure of mice from infection, restored the antifungal effector and immunomodulatory functions of the phagocytic cells, and allowed the occurrence of CD4 Th1 protective antifungal responses.	Iron	43-47	CD4 antigen	Mus musculus	236-239
9180188-6	1997	These data indicate that iron overload may negatively affect CD4 Th1 development in mice with candidiasis, a function efficiently restored by therapy with deferoxamine.	Iron	25-29	CD4 antigen	Mus musculus	61-64
24520384-11	2014	The results are consistent with a role for IL-10 in modulating iron metabolism during acute phase of infection.	Iron	63-67	interleukin 10	Homo sapiens	43-48
9195876-3	1997	Recently, two dimensional nuclear magnetic resonance (2D NMR) spectroscopic studies and molecular modeling have provided a picture of how the hydroperoxide form of cobalt BLM A2 (HOO-CoBLM), an analog of "activated" iron BLM (HOO-FeBLM), binds to a d(GpC) motif and of the basis for both sequence specificity and chemical specificity of DNA cleavage.	Iron	216-220	glycophorin C (Gerbich blood group)	Homo sapiens	251-254
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	48-52	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	140-145
9083054-7	1997	As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.	Iron	110-114	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	140-145
9083055-5	1997	Yeast strains lacking ATX1 are deficient in high affinity iron uptake and expression of HAH1 in these strains permits growth on iron-depleted media and results in restoration of copper incorporation into newly synthesized Fet3p.	Iron	128-132	antioxidant 1 copper chaperone	Homo sapiens	88-92
24508960-6	2014	The most remarkable feature of the structure is the splitting of the K-atom site and the population of the K1A and K1B positions due to substitution of Ni by Fe in the (Ni/Fe) position.	Iron	158-160	keratin 77	Homo sapiens	107-118
9067531-10	1997	The present results provide additional evidence for the existence of phenotypic and functional anomalies of the peripheral CD8+ T cell pool that may underlie the clinical heterogeneity of this iron overload disease.	Iron	193-197	CD8a molecule	Homo sapiens	123-126
24508960-6	2014	The most remarkable feature of the structure is the splitting of the K-atom site and the population of the K1A and K1B positions due to substitution of Ni by Fe in the (Ni/Fe) position.	Iron	172-174	keratin 77	Homo sapiens	107-118
24236640-6	2014	Hepatic Atoh8 mRNA levels increased in mice treated with holo transferrin, suggesting that Atoh8 responds to changes in plasma iron.	Iron	127-131	transferrin	Mus musculus	62-73
24346829-7	2014	Normalization of Fe-induced oxidative stress status occurred concomitantly with that of Nrf2 and with the Nrf2-dependent HO-1 and NQO-1 expression, which are associated with delayed enhancement in cytosolic Keap1 levels.	Iron	17-19	Kelch-like ECH-associated protein 1	Rattus norvegicus	207-212
24346829-9	2014	In conclusion, sub-chronic Fe administration leads to transient liver oxidative stress development and Nrf2 activation, as evidenced by early GSH depletion, enhanced nuclear Nrf2 protein levels, and HO-1 and NQO-1 induction, with late normalization of these changes being related to Keap1 upregulation.	Iron	27-29	heme oxygenase 1	Rattus norvegicus	199-203
24346829-9	2014	In conclusion, sub-chronic Fe administration leads to transient liver oxidative stress development and Nrf2 activation, as evidenced by early GSH depletion, enhanced nuclear Nrf2 protein levels, and HO-1 and NQO-1 induction, with late normalization of these changes being related to Keap1 upregulation.	Iron	27-29	Kelch-like ECH-associated protein 1	Rattus norvegicus	283-288
23974911-0	2014	Arabidopsis HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.	Iron	94-98	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	12-15
23974911-4	2014	Supplementation with two enzymatic by-products of HY1, carbon monoxide (CO) and iron (Fe, especially), rescued the Cd(2+)-induced inhibition of primary root (PR) elongation in hy1-100.	Iron	80-84	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	50-53
23974911-4	2014	Supplementation with two enzymatic by-products of HY1, carbon monoxide (CO) and iron (Fe, especially), rescued the Cd(2+)-induced inhibition of primary root (PR) elongation in hy1-100.	Iron	80-84	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	176-179
23974911-4	2014	Supplementation with two enzymatic by-products of HY1, carbon monoxide (CO) and iron (Fe, especially), rescued the Cd(2+)-induced inhibition of primary root (PR) elongation in hy1-100.	Iron	86-88	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	50-53
23974911-4	2014	Supplementation with two enzymatic by-products of HY1, carbon monoxide (CO) and iron (Fe, especially), rescued the Cd(2+)-induced inhibition of primary root (PR) elongation in hy1-100.	Iron	86-88	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	176-179
23974911-8	2014	Taken together, these results showed that HY1 plays a common link in Cd(2+) tolerance by decreasing NO production and improving Fe homeostasis in Arabidopsis root tissues.	Iron	128-130	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	42-45
24589591-10	2014	CONCLUSIONS: OmpT may regulate the expression of the adhesion gene iha and the transferrin gene iroN to affect the adhesion of uropathogenic E.coli to host cells.	Iron	96-100	outer membrane protease	Escherichia coli	13-17
24489950-3	2014	However, upon infection the host uses a defensive response by limiting the bioavailability of iron by a number of mechanisms including the enhanced expression of hepcidin, the master iron-regulating hormone, which reduces iron uptake from the gut and retains iron in macrophages.	Iron	94-98	hepcidin antimicrobial peptide	Mus musculus	162-170
9078480-0	1997	Beneficial effects of chromium on glucose and lipid variables in control and somatotropin-treated pigs are associated with increased tissue chromium and altered tissue copper, iron, and zinc.	Iron	176-180	somatotropin	Sus scrofa	77-89
9078480-7	1997	Somatotropin treatment led to decreased hepatic Cr, Cu, Fe, and Zn concentrations and increased total renal Cu, Fe, and Zn.	Iron	56-58	somatotropin	Sus scrofa	0-12
9078480-7	1997	Somatotropin treatment led to decreased hepatic Cr, Cu, Fe, and Zn concentrations and increased total renal Cu, Fe, and Zn.	Iron	112-114	somatotropin	Sus scrofa	0-12
9078480-10	1997	Somatotropin effects on tissue Cr, Cu, Zn, and Fe were variable and difficult to evaluate due in part to growth hormone-induced changes in organ weights.	Iron	47-49	somatotropin	Sus scrofa	0-12
9042952-0	1997	Iron modulation of LPS-induced manganese superoxide dismutase gene expression in rat tissues.	Iron	0-4	superoxide dismutase 2	Rattus norvegicus	31-61
9042952-3	1997	In normal liver iron deficiency, obtained with desferrioxamine administration, produces a decrease in the MnSOD induction by LPS, indicating that such induction could depend on tissue iron content.	Iron	16-20	superoxide dismutase 2	Rattus norvegicus	106-111
9028337-4	1997	Restriction of in vivo iron supply for ferrochelatase seemed a likely mode of action, but an approximately 30% decrease in activity of this enzyme was also observed when measured in vitro.	Iron	23-27	ferrochelatase	Mus musculus	39-53
9028337-8	1997	The results show that CP94 could cause protoporphyria in individuals of low iron status, perhaps through specifically targeting particular iron pools available to ferrochelatase and by concomitantly stimulating heme synthesis.	Iron	139-143	ferrochelatase	Mus musculus	163-177
9023196-2	1997	This gene complemented a mutant which had a TnphoA insertion in cymA and which was deficient in the respiratory reduction of iron(III), nitrate, fumarate, and manganese(IV).	Iron	125-129	cytochrome c	Shewanella oneidensis MR-1	64-68
8990169-4	1997	Analysis of OCTS3 cDNA clones revealed an open reading frame encoding a predicted protein of 34.3 kDa that shares extensive sequence similarity with E. coli endonuclease III and a related enzyme from Schizosaccharomyces pombe, including a conserved active site region and an iron/sulfur domain.	Iron	275-279	nth like DNA glycosylase 1	Homo sapiens	12-17
8990169-4	1997	Analysis of OCTS3 cDNA clones revealed an open reading frame encoding a predicted protein of 34.3 kDa that shares extensive sequence similarity with E. coli endonuclease III and a related enzyme from Schizosaccharomyces pombe, including a conserved active site region and an iron/sulfur domain.	Iron	275-279	endonuclease III	Escherichia coli	157-173
9199895-9	1997	The presence of the iron chelator diethylenetriaminepentaacetic acid during incubation of epidermal 12-lipoxygenase with both the xanthine/xanthine oxidase or the glucose/glucose oxidase systems partially protected the enzyme against inhibition, indicating that hydroxyl radical contributes to the overall inhibitory effect.	Iron	20-24	xanthine dehydrogenase	Mus musculus	139-155
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	109-113	aconitase 1	Mus musculus	136-141
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	157-161	aconitase 1	Mus musculus	109-134
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	157-161	aconitase 1	Mus musculus	136-141
24489950-3	2014	However, upon infection the host uses a defensive response by limiting the bioavailability of iron by a number of mechanisms including the enhanced expression of hepcidin, the master iron-regulating hormone, which reduces iron uptake from the gut and retains iron in macrophages.	Iron	183-187	hepcidin antimicrobial peptide	Mus musculus	162-170
8977218-3	1997	Stimulation of J774 cells and primary macrophages with IFN-gamma/LPS activates the RNA binding affinities of iron regulatory protein-1 (IRP-1) and IRP-2 for iron-responsive elements, leading to translational repression of the iron storage protein ferritin.	Iron	157-161	iron responsive element binding protein 2	Mus musculus	147-152
24489950-3	2014	However, upon infection the host uses a defensive response by limiting the bioavailability of iron by a number of mechanisms including the enhanced expression of hepcidin, the master iron-regulating hormone, which reduces iron uptake from the gut and retains iron in macrophages.	Iron	183-187	hepcidin antimicrobial peptide	Mus musculus	162-170
9372861-4	1997	Iron donors (diferric transferrin, Fe-PIH or their combination) and t-butyl hydroperoxide (t-BuOOH) had the opposite effect on GSHPx-1 gene transcription in run-on experiments.	Iron	0-4	transferrin	Mus musculus	22-33
24489950-3	2014	However, upon infection the host uses a defensive response by limiting the bioavailability of iron by a number of mechanisms including the enhanced expression of hepcidin, the master iron-regulating hormone, which reduces iron uptake from the gut and retains iron in macrophages.	Iron	183-187	hepcidin antimicrobial peptide	Mus musculus	162-170
24384540-10	2014	CONCLUSIONS: Our findings suggest that tumor progression results in increased GDF-15 secretion, which may down-regulate hepcidin expression, resulting in iron overload in cancer patients; this phenomenon has also been found in some patients with sideropenic anemia due to chronic blood loss.	Iron	154-158	growth differentiation factor 15	Homo sapiens	78-84
8969232-7	1996	Among these genes, only AtCLC-d could functionally substitute for the single yeast CLC protein, restoring iron-limited growth of a strain disrupted for this gene.	Iron	106-110	Gef1p	Saccharomyces cerevisiae S288C	26-29
24295775-5	2014	In comparison, only 88/85% and 37/32% of syn-/anti-DP were destroyed when using zinc and iron after the same time, respectively.	Iron	89-93	synemin	Homo sapiens	41-44
8955135-7	1996	In the present study, we demonstrate that BCR Tyr-246 and at least one of the closely spaced tyrosine residues, Tyr-279, Tyr-283, and Tyr-289 (3Y cluster), are phosphorylated by FES both in vitro and in 32Pi-labeled cells.	Iron	178-181	BCR activator of RhoGEF and GTPase	Homo sapiens	42-45
8955135-8	1996	Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES.	Iron	55-58	BCR activator of RhoGEF and GTPase	Homo sapiens	15-18
8955135-8	1996	Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES.	Iron	55-58	BCR activator of RhoGEF and GTPase	Homo sapiens	67-70
8955135-8	1996	Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES.	Iron	165-168	BCR activator of RhoGEF and GTPase	Homo sapiens	15-18
8961933-3	1996	Although IRP1 and IRP2 are similar proteins in that they are ubiquitously expressed and are negatively regulated by iron, they are regulated by iron by different mechanisms.	Iron	116-120	iron responsive element binding protein 2	Rattus norvegicus	18-22
8961933-3	1996	Although IRP1 and IRP2 are similar proteins in that they are ubiquitously expressed and are negatively regulated by iron, they are regulated by iron by different mechanisms.	Iron	144-148	iron responsive element binding protein 2	Rattus norvegicus	18-22
8961933-11	1996	These data suggested that IRP2 does not contain a 4Fe-4S cluster similar to the cluster in IRP1, indicating that they sense iron by different mechanisms.	Iron	124-128	iron responsive element binding protein 2	Rattus norvegicus	26-30
24454764-1	2014	The liver is the primary organ for storing iron and plays a central role in the regulation of body iron levels by secretion of the hormone Hamp1.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	139-144
24454764-1	2014	The liver is the primary organ for storing iron and plays a central role in the regulation of body iron levels by secretion of the hormone Hamp1.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	139-144
8950091-1	1996	Haem oxygenase-1 (HO-1) is a stress protein and a rate-limiting enzyme in haem degradation, generating ferrous iron, carbon monoxide and bile pigments.	Iron	111-115	heme oxygenase 1	Rattus norvegicus	0-22
24409331-0	2014	Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	29-37
8938450-1	1996	The cDNA for the PSST subunit of human mitochondrial nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase [complex I; NADH dehydrogenase (ubiquinone), Fe-S (20 kDa); EC 1.6.5.3] was generated by polymerase chain reaction (PCR) amplification of human cDNA.	Iron	166-170	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	17-21
24409331-1	2014	Hemojuvelin (Hjv) is a bone morphogenetic protein (BMP) co-receptor involved in the control of systemic iron homeostasis.	Iron	104-108	hemojuvelin BMP co-receptor	Mus musculus	0-11
24409331-1	2014	Hemojuvelin (Hjv) is a bone morphogenetic protein (BMP) co-receptor involved in the control of systemic iron homeostasis.	Iron	104-108	hemojuvelin BMP co-receptor	Mus musculus	13-16
25347084-10	2014	The down-regulated proteins are involved in energy metabolism (Gamt), iron metabolism (Ftl), and catechol metabolism (Comt).	Iron	70-74	ferritin light polypeptide 1	Mus musculus	87-90
8885841-0	1996	Bis-methionine ligation to heme iron in mutants of cytochrome b562.	Iron	32-36	mitochondrially encoded cytochrome b	Homo sapiens	51-63
8885841-3	1996	We have generated mutants of cytochrome b562 in which the histidine ligand to the heme iron (His102) has been replaced by a methionine.	Iron	87-91	mitochondrially encoded cytochrome b	Homo sapiens	29-41
8885842-0	1996	Bis-methionine ligation to heme iron in mutants of cytochrome b562.	Iron	32-36	mitochondrially encoded cytochrome b	Homo sapiens	51-63
24938019-8	2014	A number of experimental studies also demonstrated that the ability to bind MMP-9, to scavenge iron into cancer cells along with the effect on subcellular localization of transmembrane proteins such as cadherins and catenins, confers this protein the potential to enhance can cer aggressiveness and makes it an appealing target of future anticancer research.	Iron	95-99	matrix metallopeptidase 9	Homo sapiens	76-81
8885842-3	1996	Previous work has shown that, in variants of cytochrome b562 containing the H102M mutation, methionine residues provide both axial ligands to the heme iron.	Iron	151-155	mitochondrially encoded cytochrome b	Homo sapiens	45-57
23981688-0	2014	Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2alpha in cultured cells.	Iron	57-61	cytochrome b reductase 1	Homo sapiens	14-19
8840977-10	1996	A plausible explanation for the long-term effects of hemin is that excess H-ferritin generated as a result of iron-regulatory protein deactivation sequesters toxic iron, which might otherwise catalyze damaging lipid peroxidation.	Iron	110-114	ferritin heavy polypeptide 1	Mus musculus	74-84
8784177-5	1996	In Mn-depleted PSII membranes the high-spin (S = 2) non-heme iron, enhances the spin-lattice relaxation of Pheo-.	Iron	61-65	spindlin 1	Homo sapiens	39-43
8784177-5	1996	In Mn-depleted PSII membranes the high-spin (S = 2) non-heme iron, enhances the spin-lattice relaxation of Pheo-.	Iron	61-65	spindlin 1	Homo sapiens	80-84
23981688-0	2014	Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2alpha in cultured cells.	Iron	57-61	cytochrome b reductase 1	Homo sapiens	21-28
23981688-1	2014	BACKGROUND: Duodenal cytochrome b (Dcytb) is a mammalian plasma ferric reductase enzyme that catalyses the reduction of ferric to ferrous ion in the process of iron absorption.	Iron	160-164	cytochrome b reductase 1	Homo sapiens	12-33
8875074-1	1996	The iron-binding growth factor transferrin is taken up and localised in the hindgut of midgestation mouse embryos.	Iron	4-8	transferrin	Mus musculus	31-42
23981688-1	2014	BACKGROUND: Duodenal cytochrome b (Dcytb) is a mammalian plasma ferric reductase enzyme that catalyses the reduction of ferric to ferrous ion in the process of iron absorption.	Iron	160-164	cytochrome b reductase 1	Homo sapiens	35-40
23981688-5	2014	RESULTS: Iron and dehydroascorbic acid treatment of cells inhibited Dcytb mRNA and protein expression.	Iron	9-13	cytochrome b reductase 1	Homo sapiens	68-73
24720692-5	2014	Furthermore, Ca(II) addition did not change the thickness of the cake layer, but inhibited the deposition of other elements, such as Al, Si, Mg, and Fe.	Iron	149-151	carbonic anhydrase 2	Homo sapiens	13-19
8783634-1	1996	Transferrin has been proposed as the mobilization protein for iron and manganese.	Iron	62-66	transferrin	Mus musculus	0-11
8783634-7	1996	The absence of transferrin in the Hp mutant was associated with abnormal tissue distribution of radiolabeled iron; there was 4 times more 59Fe than normal in the Hp liver and 10 times less 59Fe in the spleen and blood formed elements than normal.	Iron	109-113	transferrin	Mus musculus	15-26
8783634-10	1996	These results reveal that transferrin is required for proper targeting of manganese and iron, especially from the liver to other organs, but further indicate that nontransferrin transport mechanisms for iron and manganese must exist.	Iron	88-92	transferrin	Mus musculus	26-37
8783634-10	1996	These results reveal that transferrin is required for proper targeting of manganese and iron, especially from the liver to other organs, but further indicate that nontransferrin transport mechanisms for iron and manganese must exist.	Iron	203-207	transferrin	Mus musculus	26-37
24398127-4	2014	Two articles in EMBO reports, by the Przedborski and Ganley groups, shed light on a new role for processed, cytoplasmic PINK1, and show that depletion of cellular iron levels stimulates PINK1/Parkin-independent mitophagy.	Iron	163-167	PTEN induced kinase 1	Homo sapiens	120-125
11666592-3	1996	For an iron(II) spin-state change to result from ligand cis &lt;--&gt; trans conversion, the Fe(II)(trans-L)(4)X(2) species had to exhibit a thermally-induced high-spin state &lt;--&gt; low-spin state crossover.	Iron	7-11	spindlin 1	Homo sapiens	16-20
11666592-3	1996	For an iron(II) spin-state change to result from ligand cis &lt;--&gt; trans conversion, the Fe(II)(trans-L)(4)X(2) species had to exhibit a thermally-induced high-spin state &lt;--&gt; low-spin state crossover.	Iron	7-11	spindlin 1	Homo sapiens	164-168
11666592-3	1996	For an iron(II) spin-state change to result from ligand cis &lt;--&gt; trans conversion, the Fe(II)(trans-L)(4)X(2) species had to exhibit a thermally-induced high-spin state &lt;--&gt; low-spin state crossover.	Iron	7-11	spindlin 1	Homo sapiens	164-168
8675172-1	1996	The hepatic uptake of transferrin-bound iron by a nontransferrin receptor (NTR)-mediated process was investigated using the human hepatoma cell line HuH7.	Iron	40-44	MIR7-3 host gene	Homo sapiens	149-153
8675172-2	1996	Because HuH7 cells also acquire iron from transferrin by a receptor (TR)-mediated process, TR expression was inhibited by transfecting the cells with a plasmid containing human TR complementary DNA in antisense orientation relative to a human cytomegalovirus promoter/enhancer element.	Iron	32-36	MIR7-3 host gene	Homo sapiens	8-12
24398127-4	2014	Two articles in EMBO reports, by the Przedborski and Ganley groups, shed light on a new role for processed, cytoplasmic PINK1, and show that depletion of cellular iron levels stimulates PINK1/Parkin-independent mitophagy.	Iron	163-167	PTEN induced kinase 1	Homo sapiens	186-191
24643388-0	2014	Synergistic degradation of deca-BDE by an enrichment culture and zero-valent iron.	Iron	77-81	homeobox D13	Homo sapiens	32-35
8643505-5	1996	In a cell-free translation system, recombinant IRP-1 imposes highly specific translational repression on a reporter mRNA bearing the SDH IRE, and the translation of SDH-Ip mRNA is iron regulated in D. melanogaster Schneider cells.	Iron	180-184	Iron regulatory protein 1A	Drosophila melanogaster	47-52
8643505-8	1996	The interaction between mammalian IRPs and the aconitase IRE is regulated by iron, nitric oxide, and oxidative stress (H2O2), indicating that these three signals can control the expression of mitochondrial aconitase mRNA.	Iron	77-81	ire	Drosophila melanogaster	57-60
24643388-1	2014	Debromination of decabromodiphenyl ether (deca-BDE) by microbe and by zero-valent iron (ZVI) has been reported previously.	Iron	82-86	homeobox D13	Homo sapiens	47-50
24643388-1	2014	Debromination of decabromodiphenyl ether (deca-BDE) by microbe and by zero-valent iron (ZVI) has been reported previously.	Iron	88-91	homeobox D13	Homo sapiens	47-50
24643388-2	2014	However, no study has indicated the presence of microorganisms and their effect on ZVI-mediated reduction of deca-BDE.	Iron	83-86	homeobox D13	Homo sapiens	114-117
24643388-3	2014	Synergistic degradation of deca-BDE by an enrichment culture and ZVI was studied.	Iron	65-68	homeobox D13	Homo sapiens	32-35
8611725-3	1996	To test the hypothesis that the pathologic deposits of free ferric iron located on the inner aspect of sickle cell membranes would be redox active and promote oxidation of soluble oxyhemoglobin, we incubated native versus iron-stripped sickle or normal ghost membranes with oxyhemoglobin S. We found that sickle membranes exerted an exaggerated effect on methemoglobin formation in solution, an effect completely accounted for by their abnormal content of free iron.	Iron	67-71	hemoglobin subunit gamma 2	Homo sapiens	355-368
24643388-6	2014	Correlation analysis also confirmed that ZVI was capable of enhancing microbial population in the debromination of deca-BDE.	Iron	41-44	homeobox D13	Homo sapiens	120-123
8611725-7	1996	This predicts that removal of pathologic membrane iron might help prevent the detrimental formation of methemoglobin and hemichrome in vivo, insofar as this is accelerated by transition metal.	Iron	50-54	hemoglobin subunit gamma 2	Homo sapiens	103-116
24623262-1	2014	promotes utilization of iron for erythropoiesis through intensive suppression of serum hepcidin levels in mice.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	87-95
8634457-0	1996	Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution.	Iron	95-99	ferritin heavy polypeptide 1	Mus musculus	22-40
8634457-8	1996	Gel retardation assays performed on cytoplasmic extracts of transfected cells using an iron-responsive element (IRE) as a probe revealed that in overexpressing cells, the iron-regulatory protein (IRP) had a conformation with a high RNA-binding affinity, thus leading to translational repression of the endogenous L-ferritin synthesis.	Iron	87-91	ferritin light polypeptide 1	Mus musculus	313-323
24678217-5	2014	RESULTS: Significantly lower levels (P &lt; 0.05) of CD4+ T-cells and decreased CD4:CD8 ratios were observed in the iron deficient children.	Iron	116-120	CD8a molecule	Homo sapiens	84-87
8769737-7	1996	These results suggest that oxidative stress resulting from inhibition of endogenous Cu,Zn SOD causes induction of GAPDH gene expression and that the hydroxyl radical, produced through the iron-catalyzed Haber-Weiss reaction, is the intracellular reactive oxygen species responsible for the DDC-stimulated increase in GAPDH mRNA.	Iron	188-192	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	114-119
24678217-6	2014	Iron supplementation significantly improved the CD4+ cell counts and CD4:CD8 ratios.	Iron	0-4	CD8a molecule	Homo sapiens	73-76
8769737-7	1996	These results suggest that oxidative stress resulting from inhibition of endogenous Cu,Zn SOD causes induction of GAPDH gene expression and that the hydroxyl radical, produced through the iron-catalyzed Haber-Weiss reaction, is the intracellular reactive oxygen species responsible for the DDC-stimulated increase in GAPDH mRNA.	Iron	188-192	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	317-322
24194559-4	2014	The sufS2 gene was negatively regulated by iron response regulator (Irr) and rhizobial iron regulator (RirA) under low and high iron conditions, respectively, and was inducible in response to oxidative stress.	Iron	87-91	rirA	Agrobacterium tumefaciens	103-107
8843957-0	1996	The role of iron supply in the regulation of 5-aminolevulinate synthase mRNA levels in murine erythroleukemia cells.	Iron	12-16	aminolevulinic acid synthase 2, erythroid	Mus musculus	45-71
8843957-2	1996	Iron affects translation of (ALAS-E) mRNA but nothing is known about its effect at the pretranslational level of the expression of (ALAS-E) mRNA.	Iron	0-4	aminolevulinic acid synthase 2, erythroid	Mus musculus	29-35
24194559-4	2014	The sufS2 gene was negatively regulated by iron response regulator (Irr) and rhizobial iron regulator (RirA) under low and high iron conditions, respectively, and was inducible in response to oxidative stress.	Iron	87-91	rirA	Agrobacterium tumefaciens	103-107
8530520-2	1995	IRP-IRE interactions mediate the coordinate post-transcriptional regulation of key proteins in iron metabolism, such as ferritin, transferrin receptor, and erythroid 5-aminolevulinic acid synthase.	Iron	95-99	ire	Drosophila melanogaster	4-7
24194559-7	2014	RirA may use Fe-S as its cofactor.	Iron	13-17	rirA	Agrobacterium tumefaciens	0-4
8572196-0	1995	Regulation of glucose transport and GLUT-1 expression by iron chelators in muscle cells in culture.	Iron	57-61	solute carrier family 2 member 1	Homo sapiens	36-42
24194559-9	2014	The three conserved cysteine residues (C91, C99 and C105) in RirA were predicted to coordinate with the Fe-S cluster and were shown to be essential for RirA repression of the sufS2-lacZ fusion.	Iron	104-108	rirA	Agrobacterium tumefaciens	61-65
8572196-7	1995	Increases in GLUT-1 protein and mRNA concentration, without changes in GLUT-4, were found to be responsible for iron chelator effects.	Iron	112-116	solute carrier family 2 member 1	Homo sapiens	13-19
8572196-8	1995	We conclude that L6 cells adapt to reduction in iron availability by increasing glucose utilization through an enhanced expression of GLUT-1, without losing their physiological response to insulin.	Iron	48-52	solute carrier family 2 member 1	Homo sapiens	134-140
24203231-8	2014	These results indicate that the glutaredoxin-BolA interaction occurs in several subcellular compartments and suggest that a redox regulation mechanism, disconnected from their capacity to form iron-sulfur cluster-bridged heterodimers, may be physiologically relevant for BolA2 and SufE1.	Iron	193-197	CAX interacting protein 1	Arabidopsis thaliana	32-44
8562688-2	1995	HO-2, together with HO-1 (HSP32), catalyzes oxidative cleavage of the heme molecule to biliverdin, carbon monoxide, and iron; HO-2 is the major isozyme of the testis.	Iron	120-124	heme oxygenase 1	Rattus norvegicus	20-24
8562688-2	1995	HO-2, together with HO-1 (HSP32), catalyzes oxidative cleavage of the heme molecule to biliverdin, carbon monoxide, and iron; HO-2 is the major isozyme of the testis.	Iron	120-124	heme oxygenase 1	Rattus norvegicus	26-31
25217584-3	2014	The action of the oxidase (LSD1) and a dioxygenase (JMJD2A) in the presence of Fe++ elicits an oxidation wave that locally modifies the DNA and recruits the enzymes involved in base and nucleotide excision repair (BER and NER).	Iron	79-83	lysine demethylase 1A	Homo sapiens	27-31
8659090-4	1995	G-6-PD activity was evaluated in the erythrocytes of sheep kept in the region contaminated by heavy metals with mercury dominating among them, and in the same animals after administration of a feed mixture containing Hg, Pb Cd, Zn Cr, Cu, Fe and As (Fig.	Iron	239-241	glucose-6-phosphate 1-dehydrogenase	Ovis aries	0-6
25217584-3	2014	The action of the oxidase (LSD1) and a dioxygenase (JMJD2A) in the presence of Fe++ elicits an oxidation wave that locally modifies the DNA and recruits the enzymes involved in base and nucleotide excision repair (BER and NER).	Iron	79-83	lysine demethylase 4A	Homo sapiens	52-58
23742320-4	2014	Results found in this work show that hypoxia, generated by eliminating the aeration of the nutrient solution, can limit the expression of several Fe acquisition genes in Fe-deficient Arabidopsis, cucumber and pea plants, like the genes for ferric reductases AtFRO2, PsFRO1 and CsFRO1; iron transporters AtIRT1, PsRIT1 and CsIRT1; H(+) -ATPase CsHA1; and transcription factors AtFIT, AtbHLH38, and AtbHLH39.	Iron	146-148	iron-regulated transporter 1	Arabidopsis thaliana	303-309
15299776-4	1995	Cytochrome c(4) is known to contain two covalently bound haem groups per molecule and positions of the four haem Fe atoms in the asymmetric unit were determined from native anomalous-dispersion differences.	Iron	113-115	cytochrome c3 family protein	Pseudomonas stutzeri	0-12
24192296-1	2014	In dicots, iron (Fe) is acquired from the soil by IRT1 (IRON-REGULATED TRANSPORTER 1) and FRO2 (FERRIC REDUCTION OXIDASE 2) that are localized at the root epidermis.	Iron	11-15	iron-regulated transporter 1	Arabidopsis thaliana	50-54
8584240-8	1995	Since heme is a potent inducer of HO-1, it is likely that the subarachnoid and/or intraparenchymal blood induced HO-1 in the glia where the heme was metabolized to biliverdin, iron, and carbon monoxide.	Iron	176-180	heme oxygenase 1	Rattus norvegicus	34-38
8584240-8	1995	Since heme is a potent inducer of HO-1, it is likely that the subarachnoid and/or intraparenchymal blood induced HO-1 in the glia where the heme was metabolized to biliverdin, iron, and carbon monoxide.	Iron	176-180	heme oxygenase 1	Rattus norvegicus	113-117
24192296-1	2014	In dicots, iron (Fe) is acquired from the soil by IRT1 (IRON-REGULATED TRANSPORTER 1) and FRO2 (FERRIC REDUCTION OXIDASE 2) that are localized at the root epidermis.	Iron	17-19	iron-regulated transporter 1	Arabidopsis thaliana	50-54
24192296-2	2014	IRT1 and FRO2 expression is induced by local and systemic signals under Fe-deficient conditions in Arabidopsis thaliana.	Iron	72-74	iron-regulated transporter 1	Arabidopsis thaliana	0-4
24298997-7	2014	We conclude that SKB1-mediated H4R3sme2 regulates iron homeostasis in Arabidopsis in the context of increasing or decreasing expression of Ib subgroup bHLH genes.	Iron	50-54	SHK1 binding protein 1	Arabidopsis thaliana	17-21
7554117-6	1995	This enhancement was attenuated by iron chelation with deferoxamine and by the intracellular hydroxyl scavenger dimethylthiourea and mimicked by preincubation with purine/xanthine oxidase either alone or in the presence of superoxide dismutase.	Iron	35-39	xanthine dehydrogenase	Mus musculus	171-187
24988611-0	2014	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	Iron	92-96	hephaestin	Homo sapiens	16-26
24988611-9	2014	The function of hephaestin as ferroxidase is essential for iron binding to apotransferrin in the lamina propria of the intestinal mucosa, a process that is important for further transport of iron to the liver by the portal vein.	Iron	59-63	hephaestin	Homo sapiens	16-26
24988611-9	2014	The function of hephaestin as ferroxidase is essential for iron binding to apotransferrin in the lamina propria of the intestinal mucosa, a process that is important for further transport of iron to the liver by the portal vein.	Iron	191-195	hephaestin	Homo sapiens	16-26
7548161-4	1995	NADPH would then donate two electrons, one to compound II for reduction of the iron and the other to the protein free radical.	Iron	79-83	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
24864466-8	2014	There was also a strong correlation between serum Klotho and ferritin levels and transferrin saturation percentage, which suggests that Klotho may be involved in iron regulation.	Iron	162-166	klotho	Homo sapiens	50-56
7548161-5	1995	In this paper, we report calculations to find the dominant electron tunneling pathways between NADPH and the heme iron in the catalase from the peroxide-resistant mutant of Proteus mirabilis.	Iron	114-118	2,4-dienoyl-CoA reductase 1	Homo sapiens	95-100
24864466-8	2014	There was also a strong correlation between serum Klotho and ferritin levels and transferrin saturation percentage, which suggests that Klotho may be involved in iron regulation.	Iron	162-166	klotho	Homo sapiens	136-142
24637810-1	2014	Neurodegeneration with brain iron accumulation, type 4 (NBIA4, or MPAN) is an autosomal recessive disease produced by S19org12 mutations.	Iron	29-33	chromosome 19 open reading frame 12	Homo sapiens	56-61
7547943-1	1995	Cytochrome c peroxidase (CcP) reacts with peroxide to form compound I, an intermediate that has an oxy-ferryl iron center and a stable indolyl radical at Trp 191.	Iron	110-114	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	0-23
7547943-1	1995	Cytochrome c peroxidase (CcP) reacts with peroxide to form compound I, an intermediate that has an oxy-ferryl iron center and a stable indolyl radical at Trp 191.	Iron	110-114	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	25-28
7547943-4	1995	The Trp 191--&gt;Phe enzyme [CcP(MI,F191)] reacts with peroxide to form an oxy-ferryl iron center and a transient porphyrin radical.	Iron	86-90	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	29-32
7665579-4	1995	To determine the mechanism by which iron decreases IRP2 levels, we studied IRP2 regulation by iron in rat hepatoma and human HeLa cells.	Iron	36-40	iron responsive element binding protein 2	Rattus norvegicus	51-55
7665579-4	1995	To determine the mechanism by which iron decreases IRP2 levels, we studied IRP2 regulation by iron in rat hepatoma and human HeLa cells.	Iron	94-98	iron responsive element binding protein 2	Rattus norvegicus	75-79
24279989-1	2013	Cysteine dioxygenase (CDO) is a non-heme iron enzyme that catalyzes the O2-dependent oxidation of l-cysteine (l-Cys) to produce cysteinesulfinic acid (CSA).	Iron	41-45	cysteine dioxygenase 1, cytosolic	Mus musculus	22-25
7544575-6	1995	These results indicate that ferrochelatase activity can be modulated by NO synthesis probably through disruption of the iron-sulphur cluster.	Iron	120-124	ferrochelatase	Homo sapiens	28-42
24279989-2	2013	Adjacent to the Fe site of CDO is a covalently cross-linked cysteine-tyrosine pair (C93-Y157).	Iron	16-18	cysteine dioxygenase 1, cytosolic	Mus musculus	27-30
7649160-7	1995	Such probes have shown that FM1 and FM2 transcripts accumulate with differential kinetics in response to iron; FM1 mRNA accumulate earlier than FM2 mRNA and only FM2 transcripts accumulate in response to exogenous abscisic acid or water stress.	Iron	105-109	ferritin-1, chloroplastic	Zea mays	28-31
7649160-9	1995	This raises the possibility that the differential accumulation of FM1 and FM2 mRNAs in response to iron, abscisic acid and drought could be due to differential transcription of ZmFer1 and ZmFer2.	Iron	99-103	ferritin-1, chloroplastic	Zea mays	66-69
24376517-1	2013	TMPRSS6 is a regulated gene, with a crucial role in the regulation of iron homeostasis by inhibiting hepcidin expression.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	101-109
7649160-9	1995	This raises the possibility that the differential accumulation of FM1 and FM2 mRNAs in response to iron, abscisic acid and drought could be due to differential transcription of ZmFer1 and ZmFer2.	Iron	99-103	ferritin-1, chloroplastic	Zea mays	177-183
7499788-0	1995	Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94.	Iron	14-18	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	94-98
24376517-2	2013	The main regulator of iron homeostasis, the antimicrobial peptide hepcidin, which also has a role in immunity, is directly upregulated by inflammation.	Iron	22-26	hepcidin antimicrobial peptide	Mus musculus	66-74
7499788-5	1995	The bidentate chelators CP20 and CP94 (150 microM) appeared to be as effective as the hexadentate chelator desferrioxamine (50 microM) in the protection of rat and human hepatocytes against the toxic effect of iron load achieved by culturing the cells for 1 day in the presence of 50 microM iron citrate.	Iron	210-214	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	24-28
24376517-8	2013	TMPRSS6 inhibition via decreased STAT5 phosphorylation may be an additional mechanism by which inflammation stimulates hepcidin expression to regulate iron homeostasis and immunity.	Iron	151-155	hepcidin antimicrobial peptide	Mus musculus	119-127
24258305-2	2014	The aims of this study were to investigate whether i) elevated C-FGF23 concentrations in Gambian children persist long term; ii) they are associated with higher intact FGF23 concentrations (I-FGF23), poor iron status and shorter 25-hydroxyvitamin D half-life (25OHD-t1/2); and iii) the persistence and predictors of elevated FGF23 concentrations differ between children with and without a history of rickets.	Iron	205-209	fibroblast growth factor 23	Homo sapiens	65-70
7622457-1	1995	Presence of multiple IRP2 transcripts regulated by intracellular iron levels.	Iron	65-69	iron responsive element binding protein 2	Rattus norvegicus	21-25
24349400-9	2013	Increased serum-ferritin, TBARS, hepcidin and dry weight of iron in the liver and heart showed a significant reduction in groups treated with iron chelators with maximum reduction in the group treated with a combination of deferiprone, deferasirox and hydroxyurea.	Iron	142-146	hepcidin antimicrobial peptide	Mus musculus	33-41
7574150-7	1995	Serum ceruloplasmin content was determined colorimetrically (with p-phenylenediamine dihydrochloride as substrate) as an indirect indicator of subclinical inflammation, which may result in impaired iron utilization.	Iron	198-202	ceruloplasmin	Canis lupus familiaris	6-19
24123375-1	2013	Hepcidin is a key regulator of iron metabolism.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	0-8
7653998-6	1995	The mechanism of ODC induction by CPBA is iron dependent.	Iron	42-46	ornithine decarboxylase, structural 1	Mus musculus	17-20
24123375-2	2013	The expression of hepcidin is significantly induced by iron overload, inflammation, and infection of pathogens.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	18-26
7789331-3	1995	PModS modulates the differentiated functions of Sertoli cells in vitro, including stimulation of the iron-binding protein transferrin (Tf).	Iron	101-105	transferrin	Mus musculus	122-133
7789331-3	1995	PModS modulates the differentiated functions of Sertoli cells in vitro, including stimulation of the iron-binding protein transferrin (Tf).	Iron	101-105	transferrin	Mus musculus	135-137
24123375-8	2013	Our results demonstrated a negative role of hepcidin in modulating liver regeneration, and suggested that a sustained high iron level by the down-regulation of hepcidin at the late stage of liver regeneration is required for hepatocyte proliferation.	Iron	123-127	hepcidin antimicrobial peptide	Mus musculus	44-52
24123375-8	2013	Our results demonstrated a negative role of hepcidin in modulating liver regeneration, and suggested that a sustained high iron level by the down-regulation of hepcidin at the late stage of liver regeneration is required for hepatocyte proliferation.	Iron	123-127	hepcidin antimicrobial peptide	Mus musculus	160-168
23999030-10	2013	The cytotoxic effects of NDRG1 up-regulation induced by an iron chelator were also confirmed.	Iron	59-63	N-myc downstream regulated 1	Homo sapiens	25-30
7540719-3	1995	The iron-responsive element was introduced in the 5" untranslated regions of alpha-globin mRNAs that harbored in their 3" untranslated regions either the c-fos ARE or the granulocyte-macrophage colony-stimulating factor ARE as prototypes of the different ARE subsets.	Iron	4-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-159
23983135-6	2013	When comparing the highest with the lowest tertile of intake, heme iron intake was associated with an increased risk of CRC harboring activating mutations in KRAS (hazard ratio = 1.71, 95% confidence interval: 1.15-2.57; P for trend = 0.03) and CRC without truncating mutations in APC (hazard ratio = 1.79, 95% confidence interval: 1.23-2.60; P for trend = 0.003).	Iron	67-71	KRAS proto-oncogene, GTPase	Homo sapiens	158-162
7759520-3	1995	Cytochrome b558 purified from pig neutrophils was studied to characterize the spin state of the heme iron in relation to its O2-.	Iron	101-105	cytochrome b	Sus scrofa	0-12
23983135-7	2013	We observed a positive association between heme iron intake and the risk of CRC with activating G&gt;A mutations in KRAS (P for trend = 0.01) and overall G&gt;A mutations in APC (P for trend = 0.005).	Iron	48-52	KRAS proto-oncogene, GTPase	Homo sapiens	116-120
24145116-9	2013	Many of the 39 microarray-identified genes putatively associated at the transcript expression level with fast-growing 3NGHTg salmon juveniles (including APOA1, APOA4, B2M, FADSD6, FTM, and GAPDH) are involved in metabolism, iron homeostasis and oxygen transport, and immune- or stress-related responses.	Iron	224-228	apolipoprotein A-I	Salmo salar	160-165
7756260-1	1995	The highly conserved amino acid sequence PCDGPGRGGTC in both photosystem I reaction center core proteins PsaA and PsaB has been predicted to contribute the four cysteine ligands for coordination of the 4Fe-4S iron-sulfur cluster FX, and we have proposed a working model for the binding of PsaC to this domain of the reaction center core heterodimer [Rodday et al.	Iron	209-213	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	114-118
23962819-2	2013	In this review we highlight recent studies unveiling the critical role that iron-sulfur clusters play in control of Aft1/2 and Yap5 activity, as well as the complex relationship between iron homeostasis and thiol redox metabolism.	Iron	76-80	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	116-122
7616120-8	1995	In contrast, MnSOD mRNA was decreased compared to controls in animals that developed pathologic liver injury, i.e., CE and FE groups.	Iron	123-125	superoxide dismutase 2	Rattus norvegicus	13-18
23468095-0	2013	Iron chelator alleviates tubulointerstitial fibrosis in diabetic nephropathy rats by inhibiting the expression of tenascinC and other correlation factors.	Iron	0-4	tenascin C	Rattus norvegicus	114-123
7720713-8	1995	Conversely, a strain with interruption of the AFT1 gene manifests low ferric reductase and ferrous iron uptake and is susceptible to iron deprivation, because of deficient expression of FRE1 and negligible expression of FRE2 and FET3.	Iron	99-103	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	46-50
23744538-0	2013	Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice.	Iron	6-10	hepcidin antimicrobial peptide	Mus musculus	21-29
7720713-8	1995	Conversely, a strain with interruption of the AFT1 gene manifests low ferric reductase and ferrous iron uptake and is susceptible to iron deprivation, because of deficient expression of FRE1 and negligible expression of FRE2 and FET3.	Iron	133-137	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	46-50
7720713-9	1995	Thus, AFT1 functions to activate transcription of target genes in response to iron deprivation and thereby plays a central role in iron homeostasis.	Iron	78-82	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	6-10
7720713-9	1995	Thus, AFT1 functions to activate transcription of target genes in response to iron deprivation and thereby plays a central role in iron homeostasis.	Iron	131-135	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	6-10
23744538-1	2013	UNLABELLED: The liver-derived peptide hepcidin controls the balance between iron demand and iron supply.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	38-46
23744538-1	2013	UNLABELLED: The liver-derived peptide hepcidin controls the balance between iron demand and iron supply.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	38-46
23744538-2	2013	By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body"s stores.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	55-63
23744538-2	2013	By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body"s stores.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	55-63
7716188-4	1995	radical generated by photoexcitation of NAD(P)H with a 355 nm laser pulse under anaerobic conditions also reduced cytochrome b558 with a high rate constant of 4.3 x 10(8) M-1 s-1 at pH 7.4 and 20 degrees C. The reduction of cytochrome b558 accompanied a simultaneous reduction of a component having an absorption band around 420 nm, suggesting participation of an iron-sulfur (Fe-S) cluster.	Iron	364-368	mitochondrially encoded cytochrome b	Homo sapiens	114-126
23744538-5	2013	We observed a very strong down-regulation of hepcidin in Tg6 mice that was accompanied by a strong increase in duodenal expression of ferroportin and divalent metal tranporter-1, as well as enhanced duodenal iron absorption.	Iron	208-212	hepcidin antimicrobial peptide	Mus musculus	45-53
7716188-4	1995	radical generated by photoexcitation of NAD(P)H with a 355 nm laser pulse under anaerobic conditions also reduced cytochrome b558 with a high rate constant of 4.3 x 10(8) M-1 s-1 at pH 7.4 and 20 degrees C. The reduction of cytochrome b558 accompanied a simultaneous reduction of a component having an absorption band around 420 nm, suggesting participation of an iron-sulfur (Fe-S) cluster.	Iron	364-368	mitochondrially encoded cytochrome b	Homo sapiens	224-236
7716188-4	1995	radical generated by photoexcitation of NAD(P)H with a 355 nm laser pulse under anaerobic conditions also reduced cytochrome b558 with a high rate constant of 4.3 x 10(8) M-1 s-1 at pH 7.4 and 20 degrees C. The reduction of cytochrome b558 accompanied a simultaneous reduction of a component having an absorption band around 420 nm, suggesting participation of an iron-sulfur (Fe-S) cluster.	Iron	377-382	mitochondrially encoded cytochrome b	Homo sapiens	114-126
23744538-7	2013	To elucidate the primary signal affecting hepcidin expression during chronically elevated erythropoiesis, we increased iron availability by either providing iron (thus further increasing the hematocrit) or reducing erythropoiesis-dependent iron consumption by means of splenectomy.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	42-50
7716188-4	1995	radical generated by photoexcitation of NAD(P)H with a 355 nm laser pulse under anaerobic conditions also reduced cytochrome b558 with a high rate constant of 4.3 x 10(8) M-1 s-1 at pH 7.4 and 20 degrees C. The reduction of cytochrome b558 accompanied a simultaneous reduction of a component having an absorption band around 420 nm, suggesting participation of an iron-sulfur (Fe-S) cluster.	Iron	377-382	mitochondrially encoded cytochrome b	Homo sapiens	224-236
23744538-10	2013	Rather, these results indicate that iron consumption for erythropoiesis modulates liver iron content, and ultimately BMP6 and hepcidin.	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	126-134
23744538-11	2013	Analysis of the BMP6/SMAD pathway targets showed that inhibitor of DNA binding 1 (ID1) and SMAD7, but not transmembrane serine protease 6 (TMPRSS6), were up-regulated by increased iron availability and thus may be involved in setting the upper limit of hepcidin.	Iron	180-184	inhibitor of DNA binding 1, HLH protein	Mus musculus	54-80
23744538-11	2013	Analysis of the BMP6/SMAD pathway targets showed that inhibitor of DNA binding 1 (ID1) and SMAD7, but not transmembrane serine protease 6 (TMPRSS6), were up-regulated by increased iron availability and thus may be involved in setting the upper limit of hepcidin.	Iron	180-184	inhibitor of DNA binding 1, HLH protein	Mus musculus	82-85
7852403-6	1995	The results provide further evidence that a low-spin heme iron of cytochrome b558 with a g-value of 3.2 is essential to the O2(-)-forming reaction of the NADPH oxidase system.	Iron	58-62	cytochrome b	Sus scrofa	66-78
23744538-12	2013	CONCLUSION: We provide evidence that under conditions of excessive and effective erythropoiesis, liver iron regulates hepcidin expression through the BMP6/SMAD pathway.	Iron	103-107	hepcidin antimicrobial peptide	Mus musculus	118-126
24371169-1	2013	Fat mass and obesity-associated (FTO) gene codes for a nuclear protein of the AlkB related nonhaem iron and 2-oxoglutaratedependent oxygenase superfamily, and is involved in animal fat deposition and human obesity.	Iron	99-103	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	78-82
7744315-7	1995	In each procedure, the EPR signal obtained from the cells supplemented with iron was substantially reduced in the presence of either DFO or CP20 but not with Pa.	Iron	76-80	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	140-144
7836366-0	1995	The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase.	Iron	49-53	ferroxidase	Saccharomyces cerevisiae S288C	91-102
7836366-4	1995	In this communication, we demonstrate that the gene product is a cell surface ferroxidase involved in iron transport.	Iron	102-106	ferroxidase	Saccharomyces cerevisiae S288C	78-89
7836366-6	1995	Comparison of the rate of iron oxidation to O2 consumption yielded an approximate value of 4:1, as predicted for a ferroxidase.	Iron	26-30	ferroxidase	Saccharomyces cerevisiae S288C	115-126
7836366-8	1995	Treatment of spheroplasts with trypsin or affinity-purified antibodies directed against the putative external ferroxidase domain of Fet3 had no effect on basal O2 consumption but inhibited the iron-dependent increase in O2 consumption.	Iron	193-197	ferroxidase	Saccharomyces cerevisiae S288C	110-121
24437279-1	2013	Transferrin receptor 1(TfR1) is a key cell surface molecule that regulates the uptake of iron-bound transferrin.	Iron	89-93	transferrin	Mus musculus	0-11
7836366-10	1995	These studies indicate that Fet3 is a plasma membrane ferroxidase required for high affinity iron uptake, in which the ferroxidase-containing domain is localized on the external cell surface.	Iron	93-97	ferroxidase	Saccharomyces cerevisiae S288C	54-65
7836366-10	1995	These studies indicate that Fet3 is a plasma membrane ferroxidase required for high affinity iron uptake, in which the ferroxidase-containing domain is localized on the external cell surface.	Iron	93-97	ferroxidase	Saccharomyces cerevisiae S288C	119-130
7710314-3	1995	In the case of an infant presenting with marked imprints of a hot iron abuse was to be differentiated versus an accidental causation.	Iron	66-70	alcohol dehydrogenase iron containing 1	Homo sapiens	62-65
24437279-1	2013	Transferrin receptor 1(TfR1) is a key cell surface molecule that regulates the uptake of iron-bound transferrin.	Iron	89-93	transferrin	Mus musculus	100-111
24329466-0	2013	Inelastic neutron scattering study of a nonmagnetic collapsed tetragonal phase in nonsuperconducting CaFe2As2: evidence of the impact of spin fluctuations on superconductivity in the iron-arsenide compounds.	Iron	183-187	spindlin 1	Homo sapiens	137-141
7744374-5	1995	The damage of iron-loaded hepatocytes induced by CCl4 was more serious than that of control, and HGF decreased this injury only in iron-loaded hepatocytes but not in control.	Iron	131-135	hepatocyte growth factor	Rattus norvegicus	97-100
7744374-7	1995	These findings suggest that the pathological iron deposition induces the fragility of hepatocyte and that cytoprotective effect of HGF is induced by this pathological iron.	Iron	167-171	hepatocyte growth factor	Rattus norvegicus	131-134
24160751-6	2013	However, iron uptake was higher from native compared to heat denatured 5kF fractions in the cells preincubated with the DcytB antibody.	Iron	9-13	cytochrome b reductase 1	Homo sapiens	120-125
7760689-1	1995	This study was conducted to determine whether a factor responsible for reduced nicotinamide adenine dinucleotide phosphate (NADPH)-supported lipid peroxidation in rat liver microsomes is involved in iron reduction by cooperation with NADPH-cytochrome P450 reductase.	Iron	199-203	cytochrome p450 oxidoreductase	Rattus norvegicus	234-265
7760689-3	1995	All of the iron complexes with chelators such as adenosine 5"-diphosphate, pyrophosphate, nitrilotriacetate, oxalate or citrate were reduced in microsomes, although in the reconstituted system containing purified NADPH-cytochrome P450 reductase little or no iron reduction was found.	Iron	11-15	cytochrome p450 oxidoreductase	Rattus norvegicus	213-244
7760689-6	1995	All iron complexes were reduced in the presence of the fraction, using a reducing equivalent of NADPH via NADPH-cytochrome P450 reductase.	Iron	4-8	cytochrome p450 oxidoreductase	Rattus norvegicus	106-137
23418677-5	2013	Both Hp1-1 and Hp2-2 attenuate Hb-induced blood pressure response and renal iron deposition.	Iron	76-80	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	15-20
7994765-1	1994	Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron.	Iron	23-27	transferrin	Mus musculus	56-67
7994765-1	1994	Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron.	Iron	151-155	transferrin	Mus musculus	56-67
24223168-0	2013	Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice.	Iron	8-12	interleukin 11	Mus musculus	52-57
7961651-5	1994	E. coli flavodoxin binds P450c17 directly and with relatively high affinity (apparent Ks approximately 0.2 microM) at low ionic strength, as evidenced by a change in spin state of the P450c17 heme iron upon titration with flavodoxin.	Iron	197-201	steroid 17-alpha-hydroxylase/17,20 lyase	Bos taurus	25-32
7961651-5	1994	E. coli flavodoxin binds P450c17 directly and with relatively high affinity (apparent Ks approximately 0.2 microM) at low ionic strength, as evidenced by a change in spin state of the P450c17 heme iron upon titration with flavodoxin.	Iron	197-201	steroid 17-alpha-hydroxylase/17,20 lyase	Bos taurus	184-191
24223168-5	2013	Colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS treatment, with enhanced colonic IL-6 and IL-11 release and Stat3 phosphorylation.	Iron	52-56	interleukin 11	Mus musculus	159-164
7947684-0	1994	Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase.	Iron	78-82	stearoyl-CoA desaturase	Rattus norvegicus	91-114
24223168-10	2013	Intratumoral IL-6 and IL-11 expression increased in DSS-treated mice and IL-6, and possibly IL-11, were enhanced by dietary iron.	Iron	124-128	interleukin 11	Mus musculus	92-97
24223168-12	2013	Dietary iron and colonic inflammation synergistically activated colonic IL-6/IL-11-Stat3 signaling promoting tumorigenesis.	Iron	8-12	interleukin 11	Mus musculus	77-82
24048084-3	2013	RECENT FINDINGS: Genome-wide association studies identified six genetic variants including MEIS1 and BTBD9 with potential relationships with iron.	Iron	141-145	Meis homeobox 1	Homo sapiens	91-96
8083224-7	1994	A sequence encompassing a peptide corresponding to the uracil binding site was found between the NADPH/FAD-containing NH2-terminal portion of the protein and the iron-sulfur binding sites near to the COOH terminus.	Iron	162-166	2,4-dienoyl-CoA reductase 1	Homo sapiens	97-102
23787363-0	2013	Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).	Iron	0-4	ferrochelatase	Homo sapiens	49-63
7821672-0	1994	Long-distance spin-spin interactions with iron-sulphur clusters as observed by e.p.r.	Iron	42-46	spindlin 1	Homo sapiens	14-18
7821672-0	1994	Long-distance spin-spin interactions with iron-sulphur clusters as observed by e.p.r.	Iron	42-46	spindlin 1	Homo sapiens	19-23
23787363-0	2013	Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).	Iron	76-80	ferrochelatase	Homo sapiens	49-63
23787363-5	2013	Our study demonstrated that under iron deficient conditions, the aberrant splice product was increased to 56% and 50% of total FECH mRNA in erythroleukemic K562 and lymphoblastoid cell lines, respectively, both being homozygous for IVS3-48T.	Iron	34-38	ferrochelatase	Homo sapiens	127-131
24018561-0	2013	Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury.	Iron	36-40	ferritin heavy polypeptide 1	Mus musculus	16-26
8031831-4	1994	Expressed ferrochelatase exhibited iron- and zinc-chelating activities, and was found as a soluble protein.	Iron	35-39	ferrochelatase	Homo sapiens	10-24
7909515-3	1994	A similar phenomenon is also observed in mouse fibroblasts expressing a previously characterized iron-regulated human TfR mRNA (TRS-1).	Iron	97-101	tRNA-Ser (anticodon TGA) 2-1	Homo sapiens	128-133
24018561-2	2013	The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity.	Iron	77-81	ferritin heavy polypeptide 1	Mus musculus	4-24
8135751-0	1994	Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron.	Iron	85-89	acid phosphatase 5, tartrate resistant	Mus musculus	71-75
8135751-9	1994	Increase of TRAP mRNA transcripts in PMCs was inhibited by 50 microM desferrioxamine, a potent iron chelator.	Iron	95-99	acid phosphatase 5, tartrate resistant	Mus musculus	12-16
24018561-2	2013	The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity.	Iron	77-81	ferritin heavy polypeptide 1	Mus musculus	26-29
8135751-18	1994	These data indicate that expression of TRAP is regulated by iron and that this regulation is exerted at the level of gene transcription.	Iron	60-64	acid phosphatase 5, tartrate resistant	Mus musculus	39-43
24018561-8	2013	Interestingly, urinary levels of the iron acceptor proteins neutrophil gelatinase-associated lipocalin, hemopexin, and transferrin were increased in FtH(PT-/-) mice after AKI.	Iron	37-41	ferritin heavy polypeptide 1	Mus musculus	149-152
24018561-9	2013	These results underscore the protective role of FtH and reveal the critical role of proximal tubule FtH in iron trafficking in AKI.	Iron	107-111	ferritin heavy polypeptide 1	Mus musculus	100-103
7887224-0	1994	Differential effects of iron and iron carrier on hematopoietic cells differentiation and human ADA gene transfer.	Iron	33-37	adenosine deaminase	Homo sapiens	95-98
24179128-0	2013	The evolutionarily conserved iron-sulfur protein INDH is required for complex I assembly and mitochondrial translation in Arabidopsis [corrected].	Iron	29-33	INDH1(iron-sulfur protein required for NADH dehydrogenase)	Arabidopsis thaliana	49-53
7710263-1	1994	In calves with severe iron (Fe) deficiency, insulin-like growth factor (IGF)-I levels and IGF-I responses to exogenous growth hormone (GH) are reduced, while insulin-dependent glucose utilization is enhanced.	Iron	22-26	IGFI	Bos taurus	44-78
7710263-1	1994	In calves with severe iron (Fe) deficiency, insulin-like growth factor (IGF)-I levels and IGF-I responses to exogenous growth hormone (GH) are reduced, while insulin-dependent glucose utilization is enhanced.	Iron	28-30	IGFI	Bos taurus	44-78
7710263-1	1994	In calves with severe iron (Fe) deficiency, insulin-like growth factor (IGF)-I levels and IGF-I responses to exogenous growth hormone (GH) are reduced, while insulin-dependent glucose utilization is enhanced.	Iron	28-30	IGFI	Bos taurus	90-95
24494240-4	2013	In this study, Fe deficiency was created using Fe-deficient growth conditions, excess zinc (Zn), and use of the irt1-1 mutant in which the IRT1 Fe transporter is disrupted.	Iron	15-17	iron-regulated transporter 1	Arabidopsis thaliana	112-116
10008368-0	1993	Spin-resolved x-ray-photoelectron-spectroscopy study of ferromagnetic iron.	Iron	70-74	spindlin 1	Homo sapiens	0-4
24494240-4	2013	In this study, Fe deficiency was created using Fe-deficient growth conditions, excess zinc (Zn), and use of the irt1-1 mutant in which the IRT1 Fe transporter is disrupted.	Iron	15-17	iron-regulated transporter 1	Arabidopsis thaliana	139-143
24126234-1	2013	Heme oxygenase (HO) is a rate-limiting step of heme degradation, which catalyzes the conversion of heme into biliverdin, iron, and CO. HO has been characterized in microorganisms, insects, plants, and mammals.	Iron	121-125	Heme oxygenase	Drosophila melanogaster	16-18
8286614-2	1993	One example is uteroferrin (Uf), an iron-containing, purple-colored acid phosphatase secreted by the uterus of the pig during pregnancy.	Iron	36-40	acid phosphatase 5, tartrate resistant	Sus scrofa	15-26
8286614-2	1993	One example is uteroferrin (Uf), an iron-containing, purple-colored acid phosphatase secreted by the uterus of the pig during pregnancy.	Iron	36-40	acid phosphatase 5, tartrate resistant	Sus scrofa	28-30
8246983-1	1993	The gene for the iron-binding protein transferrin is transcribed at a high level in liver hepatocytes but is also active in several other cell types, including oligodendrocytes in the brain.	Iron	17-21	transferrin	Mus musculus	38-49
8226890-3	1993	Growth arrest of yeast caused by low concentrations of 1,10-phenanthroline, resulting in zinc and/or iron deprivation, is overcome by over-expression of YAP1 or YAP2.	Iron	101-105	Cad1p	Saccharomyces cerevisiae S288C	161-165
7683679-0	1993	Mechanisms for negative regulation by iron of the fatA outer membrane protein gene expression in Vibrio anguillarum 775.	Iron	38-42	ferric anguibactin receptor	Vibrio anguillarum 775	50-54
7683679-1	1993	Synthesis of the 86-kDa FatA outer membrane protein is repressed under iron-rich conditions.	Iron	71-75	ferric anguibactin receptor	Vibrio anguillarum 775	24-28
7683679-3	1993	This RNA is only expressed under iron-rich conditions and acts as a negative regulator of FatA synthesis, with slight but discernible decrease in the steady-state level of fatA mRNA determined by RNase protection and by Northern blot analysis.	Iron	33-37	ferric anguibactin receptor	Vibrio anguillarum 775	90-94
8337255-4	1993	Porphyrin accumulation was enhanced by Ca Mg ethylenediaminetetraacetic acid, a ferrochelatase inhibitor, and the enhancement was reversed by the addition of iron, suggesting the utilization of iron by ferrochelatase.	Iron	158-162	ferrochelatase	Homo sapiens	202-216
8337255-4	1993	Porphyrin accumulation was enhanced by Ca Mg ethylenediaminetetraacetic acid, a ferrochelatase inhibitor, and the enhancement was reversed by the addition of iron, suggesting the utilization of iron by ferrochelatase.	Iron	194-198	ferrochelatase	Homo sapiens	202-216
8318915-8	1993	The opposite was observed when the iron level in the low molecular mass intracellular nonheme iron pool was elevated by treatment with either diferric transferrin (Fe-Tf) or ferric pyridoxal isonicotinoylhydrazone (Fe-PIH).	Iron	35-39	transferrin	Mus musculus	151-162
8318915-8	1993	The opposite was observed when the iron level in the low molecular mass intracellular nonheme iron pool was elevated by treatment with either diferric transferrin (Fe-Tf) or ferric pyridoxal isonicotinoylhydrazone (Fe-PIH).	Iron	94-98	transferrin	Mus musculus	151-162
8318916-1	1993	Our previous research has demonstrated that in hemoglobin-synthesizing cells, as compared with nonerythroid cells, a step in iron transport from transferrin localized between the transferrin receptor and ferrochelatase is rate-limiting for the synthesis of heme.	Iron	125-129	transferrin	Mus musculus	145-156
8318916-1	1993	Our previous research has demonstrated that in hemoglobin-synthesizing cells, as compared with nonerythroid cells, a step in iron transport from transferrin localized between the transferrin receptor and ferrochelatase is rate-limiting for the synthesis of heme.	Iron	125-129	transferrin	Mus musculus	179-190
8318916-1	1993	Our previous research has demonstrated that in hemoglobin-synthesizing cells, as compared with nonerythroid cells, a step in iron transport from transferrin localized between the transferrin receptor and ferrochelatase is rate-limiting for the synthesis of heme.	Iron	125-129	ferrochelatase	Mus musculus	204-218
8318916-5	1993	3) Following induction of MEL cells there is an increase in the stability of transferrin receptor mRNA whose level is only slightly affected by iron excess.	Iron	144-148	transferrin	Mus musculus	77-88
10005059-0	1993	Effect of substrate-imposed strain on the growth of metallic overlayers calculated for fcc and hcp iron.	Iron	99-103	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	95-98
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	13-17	transferrin	Mus musculus	73-84
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	13-17	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	161-165
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	52-56	transferrin	Mus musculus	73-84
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	52-56	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	161-165
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	52-56	transferrin	Mus musculus	73-84
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	52-56	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	161-165
8417135-9	1993	Although a major portion of iron transport across the blood-brain barrier is normally transferrin-mediated, non-transferrin-bound iron readily crosses it at low serum transferrin levels.	Iron	28-32	transferrin	Mus musculus	86-97
8417135-9	1993	Although a major portion of iron transport across the blood-brain barrier is normally transferrin-mediated, non-transferrin-bound iron readily crosses it at low serum transferrin levels.	Iron	130-134	transferrin	Mus musculus	86-97
8417135-9	1993	Although a major portion of iron transport across the blood-brain barrier is normally transferrin-mediated, non-transferrin-bound iron readily crosses it at low serum transferrin levels.	Iron	130-134	transferrin	Mus musculus	112-123
8417135-9	1993	Although a major portion of iron transport across the blood-brain barrier is normally transferrin-mediated, non-transferrin-bound iron readily crosses it at low serum transferrin levels.	Iron	130-134	transferrin	Mus musculus	112-123
1335284-0	1992	Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice.	Iron	22-26	transferrin	Mus musculus	4-15
1527027-2	1992	The iron-responsive element binding protein (IRE-BP) is a cytosolic protein that binds a highly conserved sequence in the untranslated regions of mRNAs involved in iron metabolism including ferritin, transferrin receptor, and erythroid 5-aminolevulinate acid synthase.	Iron	4-8	aconitase 1	Mus musculus	45-51
1527027-2	1992	The iron-responsive element binding protein (IRE-BP) is a cytosolic protein that binds a highly conserved sequence in the untranslated regions of mRNAs involved in iron metabolism including ferritin, transferrin receptor, and erythroid 5-aminolevulinate acid synthase.	Iron	164-168	aconitase 1	Mus musculus	45-51
1527027-13	1992	The decrease in IRE-BP RNA binding activity in extracts from iron-treated rats is reversible by pretreatment of the extracts with reducing agents.	Iron	61-65	aconitase 1	Mus musculus	16-22
1527027-14	1992	The steady-state levels of IRE-BP mRNA remain constant during iron treatment.	Iron	62-66	aconitase 1	Mus musculus	27-33
1527027-15	1992	These data suggest that the decrease in IRE-BP RNA binding activity by iron in rat liver is due to post-translational changes in the RNA binding affinity of the IRE-BP and not due a decrease in the transcription of the IRE-BP gene or to the destabilization of the IRE-BP mRNA.	Iron	71-75	aconitase 1	Mus musculus	40-46
1527027-15	1992	These data suggest that the decrease in IRE-BP RNA binding activity by iron in rat liver is due to post-translational changes in the RNA binding affinity of the IRE-BP and not due a decrease in the transcription of the IRE-BP gene or to the destabilization of the IRE-BP mRNA.	Iron	71-75	aconitase 1	Mus musculus	161-167
1527027-15	1992	These data suggest that the decrease in IRE-BP RNA binding activity by iron in rat liver is due to post-translational changes in the RNA binding affinity of the IRE-BP and not due a decrease in the transcription of the IRE-BP gene or to the destabilization of the IRE-BP mRNA.	Iron	71-75	aconitase 1	Mus musculus	161-167
1527027-15	1992	These data suggest that the decrease in IRE-BP RNA binding activity by iron in rat liver is due to post-translational changes in the RNA binding affinity of the IRE-BP and not due a decrease in the transcription of the IRE-BP gene or to the destabilization of the IRE-BP mRNA.	Iron	71-75	aconitase 1	Mus musculus	161-167
1516739-2	1992	The effect of normal rat liver cytosol on the level of Fe/ADP-ascorbate-induced lipid peroxidation in the total particulate fraction (mitochondria plus microsomes) has been studied.	Iron	55-57	seminal vesicle secretory protein 4	Rattus norvegicus	58-61
1608913-4	1992	It is likely that aluminium is transported to the brain by the iron-binding protein transferrin and enters the brain via specific transferrin receptors.	Iron	63-67	transferrin	Mus musculus	84-95
1731957-6	1992	In cells cultured with FeNTA, iron was found predominantly in an insoluble form while in the cells cultured with Fe-transferrin or FePIH the largest proportion of iron was found in the non-ferritin high molecular weight fraction, which probably represents iron in enzymes and other metabolically-important proteins.	Iron	163-167	transferrin	Mus musculus	116-127
1567935-1	1992	In the pig, iron transport to the developing fetus during pregnancy involves, in part, uteroferrin (UF), a secreted progesterone-induced protein of the uterus.	Iron	12-16	acid phosphatase 5, tartrate resistant	Sus scrofa	87-98
1567935-1	1992	In the pig, iron transport to the developing fetus during pregnancy involves, in part, uteroferrin (UF), a secreted progesterone-induced protein of the uterus.	Iron	12-16	acid phosphatase 5, tartrate resistant	Sus scrofa	100-102
1623278-4	1992	All dose levels of OMR provided marking of the bowel by increasing intraluminal signal intensity; however, the degree and percentage of small bowel opacification appeared more prominent at higher dose levels of iron.	Iron	211-215	ATP synthase F1 subunit alpha	Homo sapiens	19-22
1742489-1	1991	We used a unique animal model, the hypotransferrinemic (Htx) mouse, to examine the role of transferrin (Tf) in gastrointestinal iron uptake.	Iron	128-132	transferrin	Mus musculus	104-106
1915737-1	1991	Transferrin is a glycoprotein that functions primarily to deliver iron to the cell.	Iron	66-70	transferrin	Mus musculus	0-11
1915737-2	1991	Recent studies suggest that the transferrin receptor mediates the intracellular delivery and transport of iron bound to transferrin in the CNS.	Iron	106-110	transferrin	Mus musculus	32-43
1930282-4	1991	Reaction with hydrogen peroxide oxidizes methemoglobin to ferrylhemoglobin, which contains iron(IV)-oxo porphyrin moiety and a protein radical.	Iron	91-95	hemoglobin subunit gamma 2	Homo sapiens	41-54
24126234-1	2013	Heme oxygenase (HO) is a rate-limiting step of heme degradation, which catalyzes the conversion of heme into biliverdin, iron, and CO. HO has been characterized in microorganisms, insects, plants, and mammals.	Iron	121-125	Heme oxygenase	Drosophila melanogaster	135-137
1747422-1	1991	The effect of normal rat liver cytosol on the level of Fe/ADP-ascorbate-induced lipid peroxidation in the total particulate fraction (mitochondria plus microsomes) has been studied.	Iron	55-57	seminal vesicle secretory protein 4	Rattus norvegicus	58-61
23856315-3	2013	In this study, the removal processes of decabromodiphenyl ether (BDE-209) and monobromodiphenyl ether (BDE-3) with microscale zerovalent iron (MZVI) were investigated to get better understandings for the removal mechanism based upon adsorption and degradation.	Iron	137-141	homeobox D13	Homo sapiens	65-68
1662302-2	1991	The c-fos-immunopositive neurons were observed in a hippocampal formation, especially in the dentate gyrus and CA1 and CA2, in the vicinity of the iron injected cerebral cortex and amygdala only at 3 hours after the iron administration.	Iron	147-151	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
1662302-2	1991	The c-fos-immunopositive neurons were observed in a hippocampal formation, especially in the dentate gyrus and CA1 and CA2, in the vicinity of the iron injected cerebral cortex and amygdala only at 3 hours after the iron administration.	Iron	216-220	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
23856315-3	2013	In this study, the removal processes of decabromodiphenyl ether (BDE-209) and monobromodiphenyl ether (BDE-3) with microscale zerovalent iron (MZVI) were investigated to get better understandings for the removal mechanism based upon adsorption and degradation.	Iron	137-141	homeobox D13	Homo sapiens	103-106
23592271-3	2013	We efficiently detected small differences in macrophage steady-state iron levels in Hfe (-/-) mice as well as inflammation-induced iron sequestration upon lipopolysaccharide instillation.	Iron	69-73	homeostatic iron regulator	Mus musculus	84-87
2039523-5	1991	A synergistic action of antibodies with epitopes at the tight binding site involved in iron uptake and the antibodies which inhibit electron transport, B3/25 and GB16, can explain the increased inhibition of growth observed when both 42/6 and B3/25 are added to proliferating cells.	Iron	87-91	immunoglobulin kappa variable 4-1	Homo sapiens	152-157
2039523-5	1991	A synergistic action of antibodies with epitopes at the tight binding site involved in iron uptake and the antibodies which inhibit electron transport, B3/25 and GB16, can explain the increased inhibition of growth observed when both 42/6 and B3/25 are added to proliferating cells.	Iron	87-91	immunoglobulin kappa variable 4-1	Homo sapiens	243-248
1645740-4	1991	Early endosomal acidification appears to be normal in the mutant based on its accumulation of iron from transferrin and its sensitivity to diphtheria toxin A chain-transferrin conjugate.	Iron	94-98	transferrin	Mus musculus	104-115
23403147-1	2013	Neuroglobin, a globin characterized by a bis-histidine ligation of the heme iron, has been identified in mammalian and non-mammalian vertebrates, including fish, amphibians and reptiles.	Iron	76-80	neuroglobin	Homo sapiens	0-11
23836816-1	2013	The transferrin-binding proteins TbpA and TbpB enable Neisseria gonorrhoeae to obtain iron from human transferrin.	Iron	86-90	transthyretin	Homo sapiens	33-37
23836816-9	2013	When these mutant TbpB proteins were produced in a strain expressing a form of TbpA that requires TbpB for iron acquisition, growth on transferrin was either abrogated or dramatically diminished.	Iron	107-111	transthyretin	Homo sapiens	79-83
24018130-1	2013	Neutrophil gelatinase associated lipocalin (NGAL) protein is attracting a great interest because of its antibacterial properties played upon modulating iron content in competition against iron acquisition processes developed by pathogenic bacteria that bind selective ferric iron chelators (siderophores).	Iron	152-156	lipocalin 2	Homo sapiens	0-42
24018130-1	2013	Neutrophil gelatinase associated lipocalin (NGAL) protein is attracting a great interest because of its antibacterial properties played upon modulating iron content in competition against iron acquisition processes developed by pathogenic bacteria that bind selective ferric iron chelators (siderophores).	Iron	152-156	lipocalin 2	Homo sapiens	44-48
24018130-1	2013	Neutrophil gelatinase associated lipocalin (NGAL) protein is attracting a great interest because of its antibacterial properties played upon modulating iron content in competition against iron acquisition processes developed by pathogenic bacteria that bind selective ferric iron chelators (siderophores).	Iron	188-192	lipocalin 2	Homo sapiens	0-42
24018130-1	2013	Neutrophil gelatinase associated lipocalin (NGAL) protein is attracting a great interest because of its antibacterial properties played upon modulating iron content in competition against iron acquisition processes developed by pathogenic bacteria that bind selective ferric iron chelators (siderophores).	Iron	188-192	lipocalin 2	Homo sapiens	44-48
24018130-1	2013	Neutrophil gelatinase associated lipocalin (NGAL) protein is attracting a great interest because of its antibacterial properties played upon modulating iron content in competition against iron acquisition processes developed by pathogenic bacteria that bind selective ferric iron chelators (siderophores).	Iron	188-192	lipocalin 2	Homo sapiens	0-42
24018130-1	2013	Neutrophil gelatinase associated lipocalin (NGAL) protein is attracting a great interest because of its antibacterial properties played upon modulating iron content in competition against iron acquisition processes developed by pathogenic bacteria that bind selective ferric iron chelators (siderophores).	Iron	188-192	lipocalin 2	Homo sapiens	44-48
24018130-3	2013	The selective binding of Fe(III)-catechol ligands to NGAL is here studied by using iron coordination structures with one, two, and three catecholate ligands.	Iron	83-87	lipocalin 2	Homo sapiens	53-57
23494994-0	2013	Clinical features of neurodegeneration with brain iron accumulation due to a C19orf12 gene mutation.	Iron	50-54	chromosome 19 open reading frame 12	Homo sapiens	77-85
23727075-8	2013	Meanwhile, the activity of prototypical iron-sulfur clusters (ISCs) containing enzymes that are known to control aerobic metabolism, including complex I and aconitase, and the expression of ISC assembly scaffold protein (ISCU) were inhibited following nickel deposition.	Iron	40-44	iron-sulfur cluster assembly enzyme	Mus musculus	221-225
23685131-6	2013	Herein, we find that PEN-2 can interact with ferritin light chain (FTL), an important component of the iron storage protein ferritin.	Iron	103-107	presenilin enhancer, gamma-secretase subunit	Homo sapiens	21-26
23685131-6	2013	Herein, we find that PEN-2 can interact with ferritin light chain (FTL), an important component of the iron storage protein ferritin.	Iron	103-107	ferritin light chain	Homo sapiens	45-65
23685131-6	2013	Herein, we find that PEN-2 can interact with ferritin light chain (FTL), an important component of the iron storage protein ferritin.	Iron	103-107	ferritin light chain	Homo sapiens	67-70
23685131-8	2013	Furthermore, iron treatments increase the levels of FTL, PEN-2 and PS1 NTF and promote gamma-secretase-mediated NICD production.	Iron	13-17	ferritin light chain	Homo sapiens	52-55
23685131-8	2013	Furthermore, iron treatments increase the levels of FTL, PEN-2 and PS1 NTF and promote gamma-secretase-mediated NICD production.	Iron	13-17	presenilin enhancer, gamma-secretase subunit	Homo sapiens	57-62
23685131-10	2013	Together, our results suggest that iron can increase gamma-secretase activity through promoting the level of FTL that interacts with and stabilizes PEN-2, providing a new molecular link between iron, PEN-2/gamma-secretase and Abeta generation in AD.	Iron	35-39	ferritin light chain	Homo sapiens	109-112
23685131-10	2013	Together, our results suggest that iron can increase gamma-secretase activity through promoting the level of FTL that interacts with and stabilizes PEN-2, providing a new molecular link between iron, PEN-2/gamma-secretase and Abeta generation in AD.	Iron	35-39	presenilin enhancer, gamma-secretase subunit	Homo sapiens	148-153
23685131-10	2013	Together, our results suggest that iron can increase gamma-secretase activity through promoting the level of FTL that interacts with and stabilizes PEN-2, providing a new molecular link between iron, PEN-2/gamma-secretase and Abeta generation in AD.	Iron	35-39	presenilin enhancer, gamma-secretase subunit	Homo sapiens	200-205
23685131-10	2013	Together, our results suggest that iron can increase gamma-secretase activity through promoting the level of FTL that interacts with and stabilizes PEN-2, providing a new molecular link between iron, PEN-2/gamma-secretase and Abeta generation in AD.	Iron	194-198	ferritin light chain	Homo sapiens	109-112
23685131-10	2013	Together, our results suggest that iron can increase gamma-secretase activity through promoting the level of FTL that interacts with and stabilizes PEN-2, providing a new molecular link between iron, PEN-2/gamma-secretase and Abeta generation in AD.	Iron	194-198	presenilin enhancer, gamma-secretase subunit	Homo sapiens	148-153
23902514-0	2013	Synthesis, structures, and dearomatization by deprotonation of iron complexes featuring bipyridine-based PNN pincer ligands.	Iron	63-67	pinin, desmosome associated protein	Homo sapiens	105-108
23814049-1	2013	Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins.	Iron	78-82	RoBo-1	Rattus norvegicus	134-138
23814049-1	2013	Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins.	Iron	123-127	RoBo-1	Rattus norvegicus	134-138
23814049-2	2013	It was shown previously that an intestinal copper transporter (Atp7a) was co-regulated with iron transport-related genes by a hypoxia-inducible transcription factor, Hif2alpha.	Iron	92-96	endothelial PAS domain protein 1	Rattus norvegicus	166-175
23814049-4	2013	Initial studies in IEC-6 cells showed that mithramycin, an Sp1 inhibitor, reduced expression of Atp7a and iron transport-related genes (Dmt1, Dcytb, and Fpn1) and blocked their induction by CoCl2, a hypoxia mimetic.	Iron	106-110	RoBo-1	Rattus norvegicus	136-140
23814049-10	2013	Furthermore, this Sp1/Hif2alpha regulatory mechanism may have broader implications for understanding the genetic response of the intestinal epithelium to maintain whole-body iron homeostasis during states of deficiency.	Iron	174-178	endothelial PAS domain protein 1	Rattus norvegicus	22-31
23836059-0	2013	IL-22 regulates iron availability in vivo through the induction of hepcidin.	Iron	16-20	hepcidin antimicrobial peptide	Mus musculus	67-75
23836059-3	2013	Hepcidin is a key regulator of iron levels within the body.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	0-8
23836059-4	2013	Under conditions of iron deficiency, hepcidin expression is reduced to promote increased iron uptake from the diet and release from cells, whereas during conditions of iron excess, induction of hepcidin restricts iron uptake and movement within the body.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	37-45
23836059-4	2013	Under conditions of iron deficiency, hepcidin expression is reduced to promote increased iron uptake from the diet and release from cells, whereas during conditions of iron excess, induction of hepcidin restricts iron uptake and movement within the body.	Iron	89-93	hepcidin antimicrobial peptide	Mus musculus	37-45
23836059-4	2013	Under conditions of iron deficiency, hepcidin expression is reduced to promote increased iron uptake from the diet and release from cells, whereas during conditions of iron excess, induction of hepcidin restricts iron uptake and movement within the body.	Iron	89-93	hepcidin antimicrobial peptide	Mus musculus	37-45
23836059-8	2013	Injection of mice with exogenous mouse IgG1 Fc fused to the N terminus of mouse IL-22 (Fc-IL-22), an IL-22R agonist with prolonged and enhanced functional potency, induced hepcidin production, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant increase in iron accumulation within the spleen.	Iron	241-245	LOC105243590	Mus musculus	39-43
23836059-8	2013	Injection of mice with exogenous mouse IgG1 Fc fused to the N terminus of mouse IL-22 (Fc-IL-22), an IL-22R agonist with prolonged and enhanced functional potency, induced hepcidin production, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant increase in iron accumulation within the spleen.	Iron	298-302	LOC105243590	Mus musculus	39-43
23836059-10	2013	Ab-mediated blockade of hepcidin partially reversed the effects on iron biology caused by IL-22R stimulation.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	24-32
23836059-11	2013	Taken together, these data suggest that exogenous IL-22 regulates hepcidin production to physiologically influence iron usage.	Iron	115-119	hepcidin antimicrobial peptide	Mus musculus	66-74
23788639-6	2013	Histochemical localization of iron, visualized by Perls DAB staining, was strongly altered in a phr1 phl1 mutant, revealing that both PHR1 and PHL1 are major factors involved in the regulation of iron homeostasis.	Iron	30-34	Homeodomain-like superfamily protein	Arabidopsis thaliana	143-147
23788639-6	2013	Histochemical localization of iron, visualized by Perls DAB staining, was strongly altered in a phr1 phl1 mutant, revealing that both PHR1 and PHL1 are major factors involved in the regulation of iron homeostasis.	Iron	196-200	Homeodomain-like superfamily protein	Arabidopsis thaliana	143-147
23757263-4	2013	New subtypes of neuronal brain iron accumulation have been delineated and linked to mutations in C19orf12 and WDR45, while a new treatable form of dystonia with brain manganese deposition related to mutations in SLC30A10 has been described.	Iron	31-35	chromosome 19 open reading frame 12	Homo sapiens	97-105
23838697-2	2013	Neutrophil gelatinase-associated lipocalin (NGAL) has 2 functions: one as an antibacterial host defense protein and the other as a physiological iron carrier.	Iron	145-149	lipocalin 2	Homo sapiens	0-42
23838697-2	2013	Neutrophil gelatinase-associated lipocalin (NGAL) has 2 functions: one as an antibacterial host defense protein and the other as a physiological iron carrier.	Iron	145-149	lipocalin 2	Homo sapiens	44-48
23506423-9	2013	The data presented here establish for the first time a causal association between inflammation and iron accumulation in brain cells, probably promoted by changes in DMT1 and FPN1 expression and mediated in part by hepcidin.	Iron	99-103	RoBo-1	Rattus norvegicus	165-169
23995086-3	2013	In Arabidopsis thaliana, which uses the reduction-based method, iron-regulated transporter1 (IRT1) functions as the most important transporter for ferrous Fe uptake.	Iron	155-157	iron-regulated transporter 1	Arabidopsis thaliana	64-91
1847080-1	1991	The reaction of ferric cytochrome c peroxidase (CcP) from Saccharomyces cerevisiae with peroxide produces compound I, characterized by both an oxyferryl iron center and a protein-based free radical.	Iron	153-157	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	23-46
1847080-1	1991	The reaction of ferric cytochrome c peroxidase (CcP) from Saccharomyces cerevisiae with peroxide produces compound I, characterized by both an oxyferryl iron center and a protein-based free radical.	Iron	153-157	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	48-51
23995086-3	2013	In Arabidopsis thaliana, which uses the reduction-based method, iron-regulated transporter1 (IRT1) functions as the most important transporter for ferrous Fe uptake.	Iron	155-157	iron-regulated transporter 1	Arabidopsis thaliana	93-97
23995086-4	2013	Rapid and constitutive degradation of IRT1 allows plants to quickly respond to changing conditions to maintain Fe homeostasis.	Iron	111-113	iron-regulated transporter 1	Arabidopsis thaliana	38-42
1704134-1	1991	Ferrochelatase (protoheme ferro-lyase, EC 4.99.1.1) catalyzes the last step in the heme biosynthetic pathway, the chelation of ferrous iron and protoporphyrin to form heme.	Iron	127-139	ferrochelatase	Mus musculus	0-14
23759098-7	2013	Under iron deficiency, atnas4 displayed a lower expression of the iron uptake-related genes IRT1 and FRO2 as well as a reduced ferric reductase activity.	Iron	6-10	iron-regulated transporter 1	Arabidopsis thaliana	92-96
1704134-1	1991	Ferrochelatase (protoheme ferro-lyase, EC 4.99.1.1) catalyzes the last step in the heme biosynthetic pathway, the chelation of ferrous iron and protoporphyrin to form heme.	Iron	127-139	ferrochelatase	Mus musculus	16-37
23819597-4	2013	In Lck-Bax38&amp;1 mice, a 100 cGy dose of high-LET iron ions caused a significant dose dependent acceleration of lymphomagenesis in both males and females that was not seen with silicon ions.	Iron	52-56	BCL2-associated X protein	Mus musculus	3-18
1772577-4	1991	The plasma levels of aluminium, cadmium, mercury and selenium were increased and the contents of iron and manganese were lower in the DAT group as compared to control subjects.	Iron	97-101	solute carrier family 6 member 3	Homo sapiens	134-137
10042764-0	1990	Spin polarization of thermoemitted electrons from cesiated Ni and Fe.	Iron	66-68	spindlin 1	Homo sapiens	0-4
2280440-0	1990	Iron status of adolescent females in three schools in an urban area of Sri Lanka.	Iron	0-4	sorcin	Homo sapiens	71-74
2128188-5	1990	The bonding strengths of the model polypeptides exhibited tensile strengths of 16-24 kg/cm2 without enzyme and 29-31 kg/cm2 with tyrosinase on iron, and increased up to 10 kg/cm2 on metals by the addition of tyrosinase as an oxidant.	Iron	143-147	tyrosinase	Homo sapiens	129-139
9995828-0	1990	Local-spin-density calculations for iron: Effect of spin interpolation on ground-state properties.	Iron	36-40	spindlin 1	Homo sapiens	6-10
9995828-0	1990	Local-spin-density calculations for iron: Effect of spin interpolation on ground-state properties.	Iron	36-40	spindlin 1	Homo sapiens	52-56
2376597-9	1990	Levels of endogenous plasma transferrin also decreased in iron-treated transgenic mice.	Iron	58-62	transferrin	Mus musculus	28-39
2165054-0	1990	Transfer of iron from uteroferrin (purple acid phosphatase) to transferrin related to acid phosphatase activity.	Iron	12-16	acid phosphatase 5, tartrate resistant	Sus scrofa	22-33
2165054-1	1990	There is continuing controversy as to whether iron can be exchanged from the purple phosphatase, uteroferrin (Uf), to fetal transferrin (Tf) and whether this process might be of physiological relevance during pregnancy in the pig.	Iron	46-50	acid phosphatase 5, tartrate resistant	Sus scrofa	97-108
2165054-1	1990	There is continuing controversy as to whether iron can be exchanged from the purple phosphatase, uteroferrin (Uf), to fetal transferrin (Tf) and whether this process might be of physiological relevance during pregnancy in the pig.	Iron	46-50	acid phosphatase 5, tartrate resistant	Sus scrofa	110-112
2165054-2	1990	Here, iron transfer from Uf to apoTf at pH 7.1 was followed by measuring the loss of acid phosphatase activity from native Uf as a function of incubation conditions and time.	Iron	6-10	acid phosphatase 5, tartrate resistant	Sus scrofa	25-27
2165054-2	1990	Here, iron transfer from Uf to apoTf at pH 7.1 was followed by measuring the loss of acid phosphatase activity from native Uf as a function of incubation conditions and time.	Iron	6-10	acid phosphatase 5, tartrate resistant	Sus scrofa	123-125
2165054-5	1990	Loss of Uf iron did not occur at pH 5.3, at which pH Tf cannot bind Fe.	Iron	11-15	acid phosphatase 5, tartrate resistant	Sus scrofa	8-10
2165054-8	1990	However, the results suggested that only one of the two iron atoms at the bi-iron center on Uf was readily lost, and that exchange of the second iron occurred more slowly.	Iron	56-60	acid phosphatase 5, tartrate resistant	Sus scrofa	92-94
2165054-8	1990	However, the results suggested that only one of the two iron atoms at the bi-iron center on Uf was readily lost, and that exchange of the second iron occurred more slowly.	Iron	77-81	acid phosphatase 5, tartrate resistant	Sus scrofa	92-94
2165054-8	1990	However, the results suggested that only one of the two iron atoms at the bi-iron center on Uf was readily lost, and that exchange of the second iron occurred more slowly.	Iron	77-81	acid phosphatase 5, tartrate resistant	Sus scrofa	92-94
2165054-9	1990	Loss of iron made Uf more susceptible to denaturation.	Iron	8-12	acid phosphatase 5, tartrate resistant	Sus scrofa	18-20
2165054-11	1990	We conclude that iron can be transferred directly from Uf to apoTf in the presence of low molecular weight chelators, and that the process is likely to be of physiological significance.	Iron	17-21	acid phosphatase 5, tartrate resistant	Sus scrofa	55-57
10042933-0	1990	Spin relaxation in small free iron clusters.	Iron	30-34	spindlin 1	Homo sapiens	0-4
9993337-0	1990	Spin-polarized photoemission studies of the adsorption of O and S on Fe(001).	Iron	69-71	spindlin 1	Homo sapiens	0-4
2161619-11	1990	Pyrazole, a potent inhibitor of ADH, blocked the ability of the reconstituted system to interact with iron and microsomes to produce reactive oxygen species.	Iron	102-106	aldo-keto reductase family 1 member A1	Homo sapiens	32-35
2187144-4	1990	Two of the open reading frames (orf2, orf6) code for proteins apparently carrying iron-sulphur clusters of the 4Fe/4S ferredoxin type.	Iron	82-86	hypothetical protein	Escherichia coli	32-36
2187144-4	1990	Two of the open reading frames (orf2, orf6) code for proteins apparently carrying iron-sulphur clusters of the 4Fe/4S ferredoxin type.	Iron	82-86	hypothetical protein	Escherichia coli	38-42
33774247-6	2021	The arsenic and trace metals released via oxidation of the sulfide phases (particularly Fe sulfides) were almost entirely sequestered by the Fe(III) (oxyhydr)oxides, but acidification during the oxidation stage of the incubation resulted in the pH-dependent release of the As and trace metals (Co, Cu, Ni) (especially in the Fe-rich/organic-low soil).	Iron	88-90	general transcription factor IIE subunit 1	Homo sapiens	141-148
33771600-1	2021	Hepcidin, a circulatory hepatic peptide hormone, is associated with systemic iron homeostasis.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	0-8
33771600-2	2021	Inflammation leads to an increase in hepcidin expression, which dysregulates body iron level.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	37-45
33769053-0	2021	Oxidative alpha-C-C Bond Cleavage of 2  and 3  Alcohols to Aromatic Acids with O2 at Room Temperature via Iron Photocatalysis.	Iron	106-110	acetyl-CoA carboxylase alpha	Homo sapiens	10-19
33769053-2	2021	We developed a blue-light-driven iron catalysis for aerobic oxidation of 2  and 3  alcohols to acids via alpha-C-C bond cleavages at room temperature.	Iron	33-37	acetyl-CoA carboxylase alpha	Homo sapiens	105-114
33769053-4	2021	The iron catalyst and blue light play critical roles to enable the formation of highly reactive O radicals from alcohols and the consequent two alpha-C-C bond cleavages.	Iron	4-8	acetyl-CoA carboxylase alpha	Homo sapiens	144-153
33820875-0	2021	Hepcidin-induced reduction in iron content and PGC-1beta expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.	Iron	30-34	hepcidin antimicrobial peptide	Mus musculus	0-8
33820875-3	2021	Hepcidin is a key regulator of iron homeostasis.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	0-8
33820875-10	2021	These data showed that hepcidin protected osteoporosis by reducing iron levels in bone tissue, and in conjunction with PGC-1beta, reduced ROS production and the number of mitochondria, thus inhibiting osteoclast differentiation and bone absorption.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	23-31
33232715-10	2021	Recently, a mitochondria-specific iron transporter, mitoferrin, was identified, and the relationships among mitochondria, iron transportation, and diseases have been increasingly clarified.	Iron	34-38	solute carrier family 25 member 37	Homo sapiens	52-62
33232715-10	2021	Recently, a mitochondria-specific iron transporter, mitoferrin, was identified, and the relationships among mitochondria, iron transportation, and diseases have been increasingly clarified.	Iron	122-126	solute carrier family 25 member 37	Homo sapiens	52-62
33799862-4	2021	Lipocalin-2 (LCN2), which is a part of the lipocalin transport protein family, is a protein formally known for its role in iron transport and in inflammatory response.	Iron	123-127	lipocalin 2	Homo sapiens	0-11
33799862-4	2021	Lipocalin-2 (LCN2), which is a part of the lipocalin transport protein family, is a protein formally known for its role in iron transport and in inflammatory response.	Iron	123-127	lipocalin 2	Homo sapiens	13-17
33800732-6	2021	Administration of iron-enriched diet increased liver iron stores as well as hepcidin expression.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	76-84
25403101-0	2015	A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction.	Iron	75-79	transferrin receptor 2	Mus musculus	27-49
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	167-171	homeostatic iron regulator	Mus musculus	83-86
15626737-0	2005	Iron regulates T-lymphocyte sensitivity to the IFN-gamma/STAT1 signaling pathway in vitro and in vivo.	Iron	0-4	signal transducer and activator of transcription 1	Homo sapiens	57-62
23837404-0	2013	Cluster-randomised trial of the impact of school-based deworming and iron supplementation on the cognitive abilities of schoolchildren in Sri Lanka"s plantation sector.	Iron	69-73	sorcin	Homo sapiens	138-141
15626737-3	2005	Here we show that iron uptake mediated by the transferrin receptor (TfR) delivers a signal that leads to IFN-gammaR2 internalization and thus plays an essential role in attenuating activation of the IFN-gamma/STAT1 pathway in human T lymphocytes.	Iron	18-22	interferon gamma receptor 2	Homo sapiens	105-116
15626737-3	2005	Here we show that iron uptake mediated by the transferrin receptor (TfR) delivers a signal that leads to IFN-gammaR2 internalization and thus plays an essential role in attenuating activation of the IFN-gamma/STAT1 pathway in human T lymphocytes.	Iron	18-22	signal transducer and activator of transcription 1	Homo sapiens	209-214
15626737-4	2005	The effect of iron on IFN-gammaR2 internalization was specific as it did not affect expression of the IFN-gammaR1 binding chain.	Iron	14-18	interferon gamma receptor 2	Homo sapiens	22-33
23837404-1	2013	OBJECTIVE: To assess the impact of deworming and iron supplementation on the cognitive abilities and educational achievement of school-age children in Sri Lanka.	Iron	49-53	sorcin	Homo sapiens	151-154
23888164-7	2013	Comparing the responses to Fe deficiency in leaves to that in roots confirmed subgroup 1b bHLH transcription factors and POPEYE/BRUTUS as important regulators of Fe homeostasis in both leaf and root cells, and indicated six novel players with putative roles in Fe homeostasis that were highly expressed in leaves and roots and greatly induced by Fe deficiency.	Iron	27-29	zinc finger protein-like protein	Arabidopsis thaliana	128-134
34823954-1	2022	This study investigates the impacts of Ni doping on technetium-99 (Tc) sequestration in aqueous solutions through transformation of Fe(OH)2(s) to iron spinel (magnetite) under alkaline conditions.	Iron	146-150	general transcription factor IIE subunit 1	Homo sapiens	132-139
34823954-8	2022	The finding of the metallic Tc encapsulation indicates that Tc sequestration through Ni-doped Fe(OH)2(s)-to-iron spinel transformation process likely provides an alternative treatment pathway for Tc removal and could be combined into further waste treatment approaches.	Iron	108-112	general transcription factor IIE subunit 1	Homo sapiens	94-101
34890952-4	2022	As expected, the iron ions leaching concentration of Fe/Fe3C@NCNF-800 was very low (0.082 mg/L).	Iron	17-21	general transcription factor IIE subunit 1	Homo sapiens	53-55
23765334-2	2013	From the amplitude of the quantum size oscillations observed in the reflectivity curves the spin-dependent inelastic mean free path (IMFP) of electrons in Fe has been determined in the energy range from 5 to 16 eV above the vacuum level.	Iron	155-157	spindlin 1	Homo sapiens	92-96
23828883-1	2013	In this issue of Blood, Pasricha et al evaluated serum hepcidin and its putative pathological suppressor growth differentiation factor-15 (GDF-15) in patients with beta-thalassemia major before and after transfusion, in the context of erythropoietic activity and iron loading.	Iron	263-267	growth differentiation factor 15	Homo sapiens	139-145
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	52-56	heme oxygenase 1a	Danio rerio	0-16
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	52-56	heme oxygenase 1a	Danio rerio	18-23
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	102-106	heme oxygenase 1a	Danio rerio	0-16
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	102-106	heme oxygenase 1a	Danio rerio	18-23
23361852-0	2013	DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system.	Iron	46-50	RoBo-1	Rattus norvegicus	0-4
34953963-0	2022	Activation of vitamin D receptor inhibits Tau phosphorylation is associated with reduction of iron accumulation in APP/PS1 transgenic mice.	Iron	94-98	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	14-32
34735831-13	2022	In addition, the existence of Fe(OH)3 helps to coprecipitate the Mn(OH)2 in the Fe/Mn solution leading to a significant reduction of Mn from the solution.	Iron	80-82	general transcription factor IIE subunit 1	Homo sapiens	30-37
23633457-6	2013	Increased fumarate and decreased iron levels in FH-deficient kidney cancer cells inactivate prolyl hydroxylases, leading to stabilization of hypoxia-inducible factor (HIF)-1alpha and increased expression of genes such as VEGF and glucose transporter 1 (GLUT1) to provide fuel needed for rapid growth demands.	Iron	33-37	solute carrier family 2 member 1	Homo sapiens	230-251
34826546-0	2022	Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis.	Iron	0-4	sirtuin 1	Homo sapiens	75-80
34826546-13	2022	In addition, SIRT1 silencing alleviated iron overload-induced PARP1 downregulation and autophagy activation.	Iron	40-44	sirtuin 1	Homo sapiens	13-18
34826546-14	2022	Overall, our data suggest that iron overload in endometrial stromal cells of endometriotic or adenomyotic lesions may be involved in the inhibition of cell proliferation, simultaneously with the activation of protective autophagy via PARP1/SIRT1 signaling.	Iron	31-35	sirtuin 1	Homo sapiens	240-245
23633457-6	2013	Increased fumarate and decreased iron levels in FH-deficient kidney cancer cells inactivate prolyl hydroxylases, leading to stabilization of hypoxia-inducible factor (HIF)-1alpha and increased expression of genes such as VEGF and glucose transporter 1 (GLUT1) to provide fuel needed for rapid growth demands.	Iron	33-37	solute carrier family 2 member 1	Homo sapiens	253-258
23455710-0	2013	Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function.	Iron	14-18	aconitase 1	Mus musculus	97-128
34534708-3	2022	The pathophysiology of FGF23-induced hypophosphatemia due to certain intravenous iron formulations has been recently investigated in prospective clinical trials.	Iron	81-85	fibroblast growth factor 23	Homo sapiens	23-28
34534708-4	2022	To reach the correct diagnosis, clinicians must recognize the typical clinical manifestations of intravenous iron-induced hypophosphatemia and identify a specific pattern of biochemical changes (hyperphosphaturic hypophosphatemia triggered by high FGF23 that causes low 1,25 (OH)2 vitamin D, hypocalcemia and secondary hyperparathyroidism).	Iron	109-113	fibroblast growth factor 23	Homo sapiens	248-253
23455710-2	2013	Cellular iron homeostasis is maintained by iron regulatory proteins (IRP)-1 and 2 through their binding to cis-regulatory iron-responsive elements (IREs) in target mRNAs.	Iron	9-13	aconitase 1	Mus musculus	69-81
23455710-2	2013	Cellular iron homeostasis is maintained by iron regulatory proteins (IRP)-1 and 2 through their binding to cis-regulatory iron-responsive elements (IREs) in target mRNAs.	Iron	43-47	aconitase 1	Mus musculus	69-81
34388870-3	2022	In an aquatic ecosystem, As is typically driven by several underlying processes, such as redox transitions, microbially driven reduction of iron (Fe) oxide minerals, and release of associated As.	Iron	140-144	general transcription factor IIE subunit 1	Homo sapiens	146-148
23455710-2	2013	Cellular iron homeostasis is maintained by iron regulatory proteins (IRP)-1 and 2 through their binding to cis-regulatory iron-responsive elements (IREs) in target mRNAs.	Iron	43-47	aconitase 1	Mus musculus	69-81
23455710-6	2013	IRP1 activation alters the expression of IRP target genes and is accompanied by iron loading in the same organs.	Iron	80-84	aconitase 1	Mus musculus	0-4
23455710-8	2013	Thus, inappropriately high IRP1 activity causes disturbed body iron distribution and erythropoiesis.	Iron	63-67	aconitase 1	Mus musculus	27-31
23670084-2	2013	In patients with kidney diseases, renal tubules are exposed to a high concentration of iron owing to increased glomerular filtration of iron and iron-containing proteins, including haemoglobin, transferrin and neutrophil gelatinase-associated lipocalin (NGAL).	Iron	87-91	lipocalin 2	Homo sapiens	210-252
34987706-9	2021	Our results showed that inhibition of DMT1 by ebselen could suppress iron accumulation and lipid peroxidation, and thereby alleviate ferroptosis and EBI in SAH rats.	Iron	69-73	RoBo-1	Rattus norvegicus	38-42
23670084-2	2013	In patients with kidney diseases, renal tubules are exposed to a high concentration of iron owing to increased glomerular filtration of iron and iron-containing proteins, including haemoglobin, transferrin and neutrophil gelatinase-associated lipocalin (NGAL).	Iron	87-91	lipocalin 2	Homo sapiens	254-258
34938369-2	2021	The NF is intended to be used in food supplements up to a maximum dose of 100 mg per day, corresponding to a maximum daily intake of iron of 36 mg.	Iron	133-137	neurofascin	Homo sapiens	4-6
34938369-9	2021	The Panel considers that the NF is a source from which iron is bioavailable and it is safe under the proposed conditions of use.	Iron	55-59	neurofascin	Homo sapiens	29-31
23807651-6	2013	Iron oxidation in enterocytes is mediated mainly by hephaestin thus allowing dietary iron to enter the bloodstream.	Iron	0-4	hephaestin	Homo sapiens	52-62
34873315-0	2021	Mitochondrial Clk1-iron-DAT regulation pathway: a possible new therapeutic target for methamphetamine use disorder.	Iron	19-23	solute carrier family 6 member 3	Homo sapiens	24-27
23807651-6	2013	Iron oxidation in enterocytes is mediated mainly by hephaestin thus allowing dietary iron to enter the bloodstream.	Iron	85-89	hephaestin	Homo sapiens	52-62
23670730-2	2013	The study of the catalytic activity and selectivity of iron(III), gold(I), and Bronsted triflimides has unveiled that iron(III) triflimide [Fe(NTf2)3] is a robust catalyst under heating conditions, whereas gold(I) triflimide, even stabilized by PPh3, readily decomposes at 80  C and releases triflimidic acid (HNTf2) that can catalyze the corresponding reaction, as shown by in situ (19)F, (15)N, and (31)P NMR spectroscopy.	Iron	55-59	nuclear transport factor 2	Homo sapiens	143-147
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	51-55	membrane associated ring-CH-type finger 8	Homo sapiens	72-75
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	51-55	microRNA 122	Homo sapiens	84-91
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	118-122	membrane associated ring-CH-type finger 8	Homo sapiens	72-75
23640898-10	2013	Expression of PCBP1 and ferritin in an iron-sensitive, ccc1 yeast strain intensified the toxic effects of iron, whereas expression of PCBP4 protected the cells from iron toxicity.	Iron	39-43	Ccc1p	Saccharomyces cerevisiae S288C	55-59
34432101-2	2021	We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent beta-thalassemia major patients.	Iron	118-122	microRNA 122	Homo sapiens	84-91
34432101-7	2021	And by extension, targeting miR-let-7d, miR-122, and miR-200 might serve as novel sensitive, specific and non-invasive predictor biomarkers for cellular damage under condition of tissue iron excess.	Iron	186-190	membrane associated ring-CH-type finger 8	Homo sapiens	28-31
34432101-7	2021	And by extension, targeting miR-let-7d, miR-122, and miR-200 might serve as novel sensitive, specific and non-invasive predictor biomarkers for cellular damage under condition of tissue iron excess.	Iron	186-190	microRNA 122	Homo sapiens	40-47
34800311-0	2021	Vam6/Vps39/TRAP1-domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans.	Iron	64-68	TNF receptor associated protein 1	Homo sapiens	11-16
34800311-3	2021	In this study, we characterized one such mutant and found that the defective gene encoded a Vam6/Vps39/TRAP1 domain-containing protein required for robust growth on heme, an important iron source in host tissue.	Iron	184-188	TNF receptor associated protein 1	Homo sapiens	103-108
34800311-5	2021	C. neoformans encodes a second Vam6/Vps39/TRAP1 domain-containing protein designated Vam6/Vlp1, and we found that this protein is also required for robust growth on heme as well as on inorganic iron sources.	Iron	194-198	TNF receptor associated protein 1	Homo sapiens	42-47
23741765-3	2004	The TF receptor (TFRC) mediates the internalization of iron-loaded TF into cells (1, 2).	Iron	55-59	transferrin	Mus musculus	4-6
34757587-6	2021	RECENT FINDINGS: In addition to bone mineral factors, additional factors including iron, erythropoietin, inflammation, energy, and metabolism regulate FGF23.	Iron	83-87	fibroblast growth factor 23	Homo sapiens	151-156
23429074-0	2013	A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.	Iron	60-64	homeostatic iron regulator	Mus musculus	18-21
34558857-1	2021	Hepcidin is a liver-derived peptide hormone that limits iron egress from tissues to the bloodstream.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	0-8
34558857-3	2021	Genetic hepcidin inactivation leads to hereditary hemochromatosis, a disease of iron overload.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	8-16
34558857-4	2021	We used wild-type and Hjv-/- mice, a model of hemochromatosis, to examine the expression of ferroportin and other proteins of iron metabolism in hepcidin target tissues.	Iron	126-130	hepcidin antimicrobial peptide	Mus musculus	145-153
34558857-6	2021	In Hjv-/- mice, hepcidin messenger RNA correlated significantly with hepatic iron load (r = 0.8211, P < 0.001), but was substantially lower compared with wild-type controls.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	16-24
34558857-8	2021	A high-iron diet (2% carbonyl iron) suppressed duodenal DMT1 levels in both wild-type and Hjv-/- mice; however, it did not affect duodenal ferroportin expression in Hjv-/- mice, and only reduced it in wild-type mice.	Iron	30-34	hemojuvelin BMP co-receptor	Mus musculus	90-93
23605050-3	2013	The purpose of this study was to describe the effect of different iron and/or glucose concentrations over Mfn2, Bax, and Bcl2 expressions in a beta-pancreatic cell line (MIN6 cells).	Iron	66-70	BCL2-associated X protein	Mus musculus	112-115
34789084-2	2021	It is often caused by mutations in the iron response element (IRE) of the ferritin L-subunit (FTL) gene.	Iron	39-43	ferritin light chain	Homo sapiens	74-92
23605050-9	2013	Our study revealed that high glucose/Fe concentrations in MIN6 cells induced an increase of the Bcl2/Bax ratio, an indicator of increased cell apoptosis.	Iron	37-39	BCL2-associated X protein	Mus musculus	101-104
34789084-2	2021	It is often caused by mutations in the iron response element (IRE) of the ferritin L-subunit (FTL) gene.	Iron	39-43	ferritin light chain	Homo sapiens	94-97
23180041-0	2013	The effects of iron on FGF23-mediated Ca-P metabolism in CKD patients.	Iron	15-19	fibroblast growth factor 23	Homo sapiens	23-28
34789084-5	2021	We also reviewed the FLT gene mutations in published HHCS cases to provide experience for accurate diagnosis of similar patients.Results: A heterozygous mutation at position +33 (c.-167C > T, chr19:49468598) of the FTL gene was identified in the patient.Discussion: HHCS should be considered in the differential diagnosis of hyperferritinemia, especially in the presence of normal serum iron concentration and transferrin saturation.Conclusion: For patients with unexplained hyperferritinemia and bilateral cataracts who have experienced early vision loss, the establishment of genetic counseling is essential to diagnose other family members who are at risk in time.Abbreviations: FTL: ferritin L-subunit; HHCS: hereditary hyperferritinaemia cataract syndrome; IDT: integrated DNA technologies; IRE: iron response element; IRP: iron regulatory proteins; MRI: magnetic resonance imaging; SNV: single nucleotide variant; UTR: untranslated region.	Iron	801-805	ferritin light chain	Homo sapiens	215-218
23180041-2	2013	Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized that iron administration might lead to a further increase in FGF23, resulting in alterations to Ca-P metabolism in a stage 5 CKD population.	Iron	32-36	fibroblast growth factor 23	Homo sapiens	104-109
23180041-2	2013	Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized that iron administration might lead to a further increase in FGF23, resulting in alterations to Ca-P metabolism in a stage 5 CKD population.	Iron	32-36	fibroblast growth factor 23	Homo sapiens	198-203
34983316-0	2021	Novel C19orf12 loss-of-function variant leading to neurodegeneration with brain iron accumulation.	Iron	80-84	chromosome 19 open reading frame 12	Homo sapiens	6-14
23180041-2	2013	Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized that iron administration might lead to a further increase in FGF23, resulting in alterations to Ca-P metabolism in a stage 5 CKD population.	Iron	142-146	fibroblast growth factor 23	Homo sapiens	104-109
23180041-2	2013	Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized that iron administration might lead to a further increase in FGF23, resulting in alterations to Ca-P metabolism in a stage 5 CKD population.	Iron	142-146	fibroblast growth factor 23	Homo sapiens	198-203
23180041-11	2013	We can therefore conclude that if high levels of FGF23 are harmful, iron therapy may have a beneficial effect on bone metabolism by reducing FGF23 levels in a dialysis population.	Iron	68-72	fibroblast growth factor 23	Homo sapiens	141-146
23463547-4	2013	The present results showed that both CYP2A13 and POR were presented the highest expression levels or activity with 0.2 mM delta-aminolaevulinic acid (5-ALA), 0.02 mM Fe(3+) and 0.5-1.0 mug/ml hemin.	Iron	166-168	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	37-44
34837126-3	2022	We have previously shown that overexpression of FTL decreases the levels of the labile iron pool (LIP) and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-treated murine macrophage cells.	Iron	87-91	ferritin light polypeptide 1	Mus musculus	48-51
34727090-1	2021	OBJECTIVE: This study aimed to evaluate the effect of TFR2 on iron storage in type 2 diabetes.	Iron	62-66	transferrin receptor 2	Rattus norvegicus	54-58
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Iron	33-35	iron-regulated transporter 1	Arabidopsis thaliana	56-60
34940556-4	2021	Moreover, it has been shown that the expression of ferrochelatase (FECH, an iron-sulfur cluster enzyme that inserts iron into protoporphyrin IX to form heme), is regulated by intracellular iron level.	Iron	76-80	ferrochelatase	Homo sapiens	51-65
34940556-4	2021	Moreover, it has been shown that the expression of ferrochelatase (FECH, an iron-sulfur cluster enzyme that inserts iron into protoporphyrin IX to form heme), is regulated by intracellular iron level.	Iron	76-80	ferrochelatase	Homo sapiens	67-71
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Iron	189-191	iron-regulated transporter 1	Arabidopsis thaliana	56-60
34940556-4	2021	Moreover, it has been shown that the expression of ferrochelatase (FECH, an iron-sulfur cluster enzyme that inserts iron into protoporphyrin IX to form heme), is regulated by intracellular iron level.	Iron	116-120	ferrochelatase	Homo sapiens	51-65
34940556-4	2021	Moreover, it has been shown that the expression of ferrochelatase (FECH, an iron-sulfur cluster enzyme that inserts iron into protoporphyrin IX to form heme), is regulated by intracellular iron level.	Iron	116-120	ferrochelatase	Homo sapiens	67-71
34940556-4	2021	Moreover, it has been shown that the expression of ferrochelatase (FECH, an iron-sulfur cluster enzyme that inserts iron into protoporphyrin IX to form heme), is regulated by intracellular iron level.	Iron	189-193	ferrochelatase	Homo sapiens	51-65
34940556-4	2021	Moreover, it has been shown that the expression of ferrochelatase (FECH, an iron-sulfur cluster enzyme that inserts iron into protoporphyrin IX to form heme), is regulated by intracellular iron level.	Iron	189-193	ferrochelatase	Homo sapiens	67-71
34940556-8	2021	Finally, we will summarize what is known of FECH interactions with other proteins involved in iron metabolism in the mitochondria.	Iron	94-98	ferrochelatase	Homo sapiens	44-48
23704825-12	2013	CONCLUSION: Reducing hepatic iron deposition and CO levels by inhibiting HO-1 activity though the Nrf2/Keap pathway could be helpful in improving hepatic fibrosis and regulating PVP.	Iron	29-33	heme oxygenase 1	Rattus norvegicus	73-77
34811513-6	2021	Notably, significantly decreased iron content in striatum and hippocampus was evident in both Clk1+/- mutant mice and PC12 cells with Clk1 knockdown.	Iron	33-37	CDC-like kinase 1	Rattus norvegicus	134-138
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	14-18	CDC-like kinase 1	Rattus norvegicus	212-216
23597401-2	2013	The iron-sulfur protein HypD and the small accessory protein HypC play a central role in the generation of the CO and CN(-) ligands.	Iron	4-8	MAGE family member A3	Homo sapiens	24-28
34547371-0	2021	Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression.	Iron	81-85	CDGSH iron sulfur domain 2	Homo sapiens	11-16
34547371-5	2021	Here, we report that inducible disruption of CISD2 function causes an immediate disruption in mitochondrial labile iron (mLI), and that this disruption results in enhanced mitochondrial ROS (mROS) levels.	Iron	115-119	CDGSH iron sulfur domain 2	Homo sapiens	45-50
23597401-2	2013	The iron-sulfur protein HypD and the small accessory protein HypC play a central role in the generation of the CO and CN(-) ligands.	Iron	4-8	pre-mRNA processing factor 40 homolog B	Homo sapiens	61-65
23597401-6	2013	Treatment of HypD with EDTA led to the concomitant loss of Fe and the CO and CN(-) signatures, while oxidation by H2O2 resulted in a positive shift of the CO and CN(-) bands by 35 cm(-1) and 20 cm(-1), respectively, indicative of the ferrous iron as an immediate ligation site for the diatomic ligands.	Iron	59-61	MAGE family member A3	Homo sapiens	13-17
23597401-6	2013	Treatment of HypD with EDTA led to the concomitant loss of Fe and the CO and CN(-) signatures, while oxidation by H2O2 resulted in a positive shift of the CO and CN(-) bands by 35 cm(-1) and 20 cm(-1), respectively, indicative of the ferrous iron as an immediate ligation site for the diatomic ligands.	Iron	234-246	MAGE family member A3	Homo sapiens	13-17
34581604-6	2021	The ferric uptake regulator, Fur, was found to repress traD transcript levels, but to also have a second role, acting to allow TraD protein levels to increase only in the absence of iron.	Iron	182-186	TraD	Neisseria gonorrhoeae	127-131
23435367-1	2013	Ferredoxin 1 (FDX1; adrenodoxin) is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues.	Iron	39-43	ferredoxin 1	Homo sapiens	0-12
34668904-14	2021	DFT calculations have been carried out for {MII(TPP2-)} (M = Cu, Ni and Fe) and their anions to interpret the experimental results obtained for 1-4.	Iron	72-74	tripeptidyl peptidase 2	Homo sapiens	48-52
23435367-1	2013	Ferredoxin 1 (FDX1; adrenodoxin) is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues.	Iron	39-43	ferredoxin 1	Homo sapiens	14-18
23295455-3	2013	Here we report that arsenic activates the iron responsive transcription factor, Aft1, as a consequence of a defective high-affinity iron uptake mediated by Fet3 and Ftr1, whose mRNAs are drastically decreased upon arsenic exposure.	Iron	42-46	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	80-84
34777785-9	2021	This process is mediated by high erythroferrone and low hepcidin levels as well as dysregulated iron transport due transferrin saturation, so there may be differences as well.	Iron	96-100	transferrin	Mus musculus	115-126
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	109-113	aconitase 1	Mus musculus	188-192
34735495-10	2021	Hub genes (FPR3, C3AR1, CD14, ITGB2, RAC2 and ITGAM) related to iron death in diabetic nephropathy were obtained through gene expression differential analysis between different subtypes.	Iron	64-68	ELAV like RNA binding protein 2	Homo sapiens	0-3
34735495-10	2021	Hub genes (FPR3, C3AR1, CD14, ITGB2, RAC2 and ITGAM) related to iron death in diabetic nephropathy were obtained through gene expression differential analysis between different subtypes.	Iron	64-68	formyl peptide receptor 3	Homo sapiens	11-15
34735495-10	2021	Hub genes (FPR3, C3AR1, CD14, ITGB2, RAC2 and ITGAM) related to iron death in diabetic nephropathy were obtained through gene expression differential analysis between different subtypes.	Iron	64-68	integrin subunit alpha M	Homo sapiens	46-51
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	197-205
23635304-8	2013	Placental expression of transferrin and DMT1+IRE were also upregulated, indicating adaptive responses to ensure availability of iron to the fetus.	Iron	128-132	RoBo-1	Rattus norvegicus	40-44
34535975-6	2021	SRF upregulates nuclear receptor coactivator 4 (NCOA4) to induce ferritin and endogenous iron pool degradation by ferritinophagy, then obtained iron ions participate in the Fenton reaction to produce lipid peroxide (LPO).	Iron	89-93	nuclear receptor coactivator 4	Homo sapiens	16-46
34535975-6	2021	SRF upregulates nuclear receptor coactivator 4 (NCOA4) to induce ferritin and endogenous iron pool degradation by ferritinophagy, then obtained iron ions participate in the Fenton reaction to produce lipid peroxide (LPO).	Iron	89-93	nuclear receptor coactivator 4	Homo sapiens	48-53
34535975-6	2021	SRF upregulates nuclear receptor coactivator 4 (NCOA4) to induce ferritin and endogenous iron pool degradation by ferritinophagy, then obtained iron ions participate in the Fenton reaction to produce lipid peroxide (LPO).	Iron	144-148	nuclear receptor coactivator 4	Homo sapiens	16-46
34535975-6	2021	SRF upregulates nuclear receptor coactivator 4 (NCOA4) to induce ferritin and endogenous iron pool degradation by ferritinophagy, then obtained iron ions participate in the Fenton reaction to produce lipid peroxide (LPO).	Iron	144-148	nuclear receptor coactivator 4	Homo sapiens	48-53
23490101-0	2013	Inhibition of microbial trichloroethylene dechlorination [corrected] by Fe (III) reduction depends on Fe mineralogy: a batch study using the bioaugmentation culture KB-1.	Iron	72-74	folate receptor 1 pseudogene 1	Homo sapiens	165-169
34111633-1	2021	This study describes a versatile, robust and fast sample pre-concentration novel method based on chemical vapour deposition grown iron nanoparticles dispersed hierarchical carbon fiber forest (Fe-ACF/CNF) for the determination of multi-pesticide residue in water samples.	Iron	130-134	NPHS1 adhesion molecule, nephrin	Homo sapiens	193-203
34111633-3	2021	Fe-ACF/CNF was grown via tip growth mechanism and Fe-nanoparticles are moved to the tip of CNF.	Iron	50-52	NPHS1 adhesion molecule, nephrin	Homo sapiens	7-10
34111633-3	2021	Fe-ACF/CNF was grown via tip growth mechanism and Fe-nanoparticles are moved to the tip of CNF.	Iron	50-52	NPHS1 adhesion molecule, nephrin	Homo sapiens	91-94
23547888-10	2013	Among food insecure women, higher long-chain (n-3) polyunsaturated fatty acid (LC-PUFA) status, which reflects a more traditional food pattern, was associated with reduced risk of iron depletion.	Iron	180-184	pumilio RNA binding family member 3	Homo sapiens	82-86
34146879-1	2021	The activation of persulfate by ferrous iron (Fe(II)) is of great interest to the environmental remediation community, but the reduction of ferric iron (Fe(III)) to Fe(II) is slow and the accumulation of iron sludge resulted from the precipitation of Fe(III) is a great concern.	Iron	204-208	general transcription factor IIE subunit 1	Homo sapiens	251-258
34593305-0	2021	GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism.	Iron	88-92	growth differentiation factor 15	Homo sapiens	0-5
23547888-13	2013	The anti-inflammatory properties of LC-PUFA may be important for iron status in this population.	Iron	65-69	pumilio RNA binding family member 3	Homo sapiens	39-43
34829190-7	2021	The transcriptional activation function of the iron-sensing Aft1 factor is interrupted due to its mislocalization to the vacuole.	Iron	47-51	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	60-64
23399021-9	2013	After intravenous administration of transferrin-bound (58) Fe, the amount of (58) Fe incorporated into red blood cells was significantly greater in testosterone-treated mice than in placebo-treated mice.	Iron	59-61	transferrin	Mus musculus	36-47
34703229-11	2021	The enrichment rate of SPIONs@DFK-SBP-M13 assembly was 13.9 times higher than free SPIONs at 0.5 h, and intracellular Fe content was 3.6 times higher at 1 h. Furthermore, the DFK peptides favored cathepsin B to cleave SPIONs from the M13 templates resulting in release of SPIONs inside cells.	Iron	118-120	cathepsin B	Homo sapiens	196-207
34901334-17	2021	This condition is similar to iron infusion-induced FGF23-related hypophosphatemia in terms of the dysregulation of FGF23 due to exogenous factors.	Iron	29-33	fibroblast growth factor 23	Homo sapiens	51-56
34901334-17	2021	This condition is similar to iron infusion-induced FGF23-related hypophosphatemia in terms of the dysregulation of FGF23 due to exogenous factors.	Iron	29-33	fibroblast growth factor 23	Homo sapiens	115-120
34722560-0	2021	Hfe Gene Knock-Out in a Mouse Model of Hereditary Hemochromatosis Affects Bodily Iron Isotope Compositions.	Iron	81-85	homeostatic iron regulator	Mus musculus	0-3
34722560-1	2021	Hereditary hemochromatosis is a genetic iron overload disease related to a mutation within the HFE gene that controls the expression of hepcidin, the master regulator of systemic iron metabolism.	Iron	40-44	homeostatic iron regulator	Mus musculus	95-98
34722560-1	2021	Hereditary hemochromatosis is a genetic iron overload disease related to a mutation within the HFE gene that controls the expression of hepcidin, the master regulator of systemic iron metabolism.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	136-144
34722560-1	2021	Hereditary hemochromatosis is a genetic iron overload disease related to a mutation within the HFE gene that controls the expression of hepcidin, the master regulator of systemic iron metabolism.	Iron	179-183	homeostatic iron regulator	Mus musculus	95-98
34722560-1	2021	Hereditary hemochromatosis is a genetic iron overload disease related to a mutation within the HFE gene that controls the expression of hepcidin, the master regulator of systemic iron metabolism.	Iron	179-183	hepcidin antimicrobial peptide	Mus musculus	136-144
34722560-5	2021	Iron concentration increases in liver and red blood cells of Hfe -/- mice compared to controls.	Iron	0-4	homeostatic iron regulator	Mus musculus	61-64
34329667-0	2021	Galangin mitigates iron overload-triggered liver injury: Up-regulation of PPARgamma and Nrf2 signaling, and abrogation of the inflammatory responses.	Iron	19-23	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	74-83
34685126-6	2021	In addition, the proposed FE-AFE diode with Hf1-xZrxO2 has a superior cycling endurance and lower stimulation voltage compared to perovskite FE-diodes due to its scaling capability for resistive FE memory devices.	Iron	195-197	complement factor H	Homo sapiens	44-47
34679725-9	2021	Taken together, these findings suggest that SMILE is a novel transcriptional repressor of BMP-6-mediated hepcidin gene expression, thus contributing to the control of iron homeostasis.	Iron	167-171	hepcidin antimicrobial peptide	Mus musculus	105-113
34626211-1	2022	The present study aimed to evaluate the toxicity of the association between Fe and Mn in Oreochromis niloticus through genotoxic (micronucleus test and comet assay) and biochemical (CAT and GST enzymes) assays.	Iron	76-78	catalase	Oreochromis niloticus	182-185
34625812-7	2022	The expression of genes encoding iron transporters and oxidative stress markers in the duodenum and placenta were determined, along with hepatic expression of the gene encoding the iron regulatory hormone hepcidin and fetal iron.	Iron	181-185	hepcidin antimicrobial peptide	Mus musculus	205-213
34580211-1	2021	Iron (Fe) is an essential micronutrient whose availability is limiting in many soils.	Iron	0-4	general transcription factor IIE subunit 1	Homo sapiens	6-8
34593646-0	2021	Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-alpha/hepcidin axis.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	110-118
34593646-11	2021	Our findings suggest that securing iron availability via coordinated interplay between renal hypoxia and hepcidin down-regulation is a fundamental mechanism to activate adaptive thermogenesis.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	105-113
34390223-5	2021	An efficient enzymatic/Fenton-starvation nanoreactor PMs loaded with glucose oxidase and perfluoropentane (PGPMs) is constructed through synthesizing methoxy-PEG-carboxymethy-modified iron (Fe2+ /Fe3+ )-based metal-organic frameworks (PMs), followed by loading glucose oxidase (GOx) and perfluoropentane (PFP).	Iron	184-188	hydroxyacid oxidase 1	Homo sapiens	69-84
34390223-5	2021	An efficient enzymatic/Fenton-starvation nanoreactor PMs loaded with glucose oxidase and perfluoropentane (PGPMs) is constructed through synthesizing methoxy-PEG-carboxymethy-modified iron (Fe2+ /Fe3+ )-based metal-organic frameworks (PMs), followed by loading glucose oxidase (GOx) and perfluoropentane (PFP).	Iron	184-188	hydroxyacid oxidase 1	Homo sapiens	278-281
34473424-3	2021	The neighboring MoN4 can regulate the spin state of Fe center in FeN4 from high-spin (dxy 2 dyz 1 dxz 1 d z 2   1 d x 2 - y 2    1 ) to medium-spin (dxy 2 dyz 2 dxz 1 d z 2   1 ), where the empty d orbitals and separate d electron favor the overlap of Fe 3d with the N 2p orbitals, more effectively activating N N triple bond.	Iron	52-54	spindlin 1	Homo sapiens	38-42
34473424-3	2021	The neighboring MoN4 can regulate the spin state of Fe center in FeN4 from high-spin (dxy 2 dyz 1 dxz 1 d z 2   1 d x 2 - y 2    1 ) to medium-spin (dxy 2 dyz 2 dxz 1 d z 2   1 ), where the empty d orbitals and separate d electron favor the overlap of Fe 3d with the N 2p orbitals, more effectively activating N N triple bond.	Iron	52-54	spindlin 1	Homo sapiens	80-84
34473424-3	2021	The neighboring MoN4 can regulate the spin state of Fe center in FeN4 from high-spin (dxy 2 dyz 1 dxz 1 d z 2   1 d x 2 - y 2    1 ) to medium-spin (dxy 2 dyz 2 dxz 1 d z 2   1 ), where the empty d orbitals and separate d electron favor the overlap of Fe 3d with the N 2p orbitals, more effectively activating N N triple bond.	Iron	52-54	spindlin 1	Homo sapiens	143-147
34473424-3	2021	The neighboring MoN4 can regulate the spin state of Fe center in FeN4 from high-spin (dxy 2 dyz 1 dxz 1 d z 2   1 d x 2 - y 2    1 ) to medium-spin (dxy 2 dyz 2 dxz 1 d z 2   1 ), where the empty d orbitals and separate d electron favor the overlap of Fe 3d with the N 2p orbitals, more effectively activating N N triple bond.	Iron	252-254	spindlin 1	Homo sapiens	38-42
34473424-3	2021	The neighboring MoN4 can regulate the spin state of Fe center in FeN4 from high-spin (dxy 2 dyz 1 dxz 1 d z 2   1 d x 2 - y 2    1 ) to medium-spin (dxy 2 dyz 2 dxz 1 d z 2   1 ), where the empty d orbitals and separate d electron favor the overlap of Fe 3d with the N 2p orbitals, more effectively activating N N triple bond.	Iron	252-254	spindlin 1	Homo sapiens	143-147
34343368-2	2021	An altered MT2 cannot appropriately suppress hepatic BMP6/SMAD signaling in case of low iron, hence hepcidin excess blocks dietary iron absorption, leading to a form of anemia resistant to oral iron supplementation.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	100-108
34560438-6	2021	The groups receiving Zn or Cu chelate showed statistically confirmed higher activity of superoxide dismutase, catalase, and a higher level of glutathione in comparison to the group receiving Fe chelate.	Iron	191-193	catalase	Gallus gallus	110-118
34950482-1	2021	Understanding how natural nanoaggregates of iron (Fe) and organic matter (OM), currently identified in organic rich soil or peat, interact with metals and metalloids is environmentally significant.	Iron	44-48	oncomodulin 2	Homo sapiens	74-76
34950482-6	2021	Significantly, lower Fe-Fe coordination numbers (CN) of 0.6-1.1 relative to those in 2-line ferrihydrite (CN = 1.6) and goethite (CN = 2.1) suggest that these Fe(iii) oxyhydroxides are likely Fe-OM nanoaggregates protected by OM encapsulation and adsorption of arsenate.	Iron	192-194	oncomodulin 2	Homo sapiens	195-197
34950482-6	2021	Significantly, lower Fe-Fe coordination numbers (CN) of 0.6-1.1 relative to those in 2-line ferrihydrite (CN = 1.6) and goethite (CN = 2.1) suggest that these Fe(iii) oxyhydroxides are likely Fe-OM nanoaggregates protected by OM encapsulation and adsorption of arsenate.	Iron	192-194	oncomodulin 2	Homo sapiens	226-228
34950482-7	2021	Such structurally stabilized composites of As(v)-Fe(iii)-OM may be more widely distributed and allow oxidized As and Fe to persist in other organic-rich, reducing environments.	Iron	117-119	oncomodulin 2	Homo sapiens	57-59
34224804-5	2021	The cell-permeable molecule dimethyl malonate (DM), a competitive inhibitor of succinate dehydrogenase (SDH), significantly attenuated succinate accumulation, reduced the oxidative stress and iron levels, and mitigated the severity of the seizures and neuronal injury.	Iron	192-196	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	79-102
34224804-5	2021	The cell-permeable molecule dimethyl malonate (DM), a competitive inhibitor of succinate dehydrogenase (SDH), significantly attenuated succinate accumulation, reduced the oxidative stress and iron levels, and mitigated the severity of the seizures and neuronal injury.	Iron	192-196	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	104-107
34224804-6	2021	Our results thus indicate that the accumulation of succinate due to the reverse catalysis of SDH may exacerbate oxidative stress and thus induce iron accumulation and neuronal injury in both models.	Iron	145-149	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	93-96
34548401-0	2021	IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis.	Iron	0-4	zinc finger protein-like protein	Arabidopsis thaliana	24-30
34548401-0	2021	IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis.	Iron	43-47	zinc finger protein-like protein	Arabidopsis thaliana	24-30
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	28-30	zinc finger protein-like protein	Arabidopsis thaliana	0-6
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	28-30	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	142-149
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	64-66	zinc finger protein-like protein	Arabidopsis thaliana	0-6
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	64-66	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	142-149
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	182-184	zinc finger protein-like protein	Arabidopsis thaliana	0-6
34550363-1	2021	Friedreich"s ataxia (FRDA) is an inherited disorder caused by depletion of frataxin (FXN), a mitochondrial protein required for iron-sulfur cluster (ISC) biogenesis.	Iron	128-132	frataxin	Mus musculus	75-83
34550363-1	2021	Friedreich"s ataxia (FRDA) is an inherited disorder caused by depletion of frataxin (FXN), a mitochondrial protein required for iron-sulfur cluster (ISC) biogenesis.	Iron	128-132	frataxin	Mus musculus	85-88
34594380-11	2021	The mechanisms of poor prognosis of CYBRD1-mediated OV may include increased iron uptake, regulation of immune microenvironment, ferroptosis related pathway, and ERK signaling pathway, among which ferroptosis and ERK signaling pathway may be important pathways of CYBRD1-mediated OV.	Iron	77-81	cytochrome b reductase 1	Homo sapiens	36-42
34594380-11	2021	The mechanisms of poor prognosis of CYBRD1-mediated OV may include increased iron uptake, regulation of immune microenvironment, ferroptosis related pathway, and ERK signaling pathway, among which ferroptosis and ERK signaling pathway may be important pathways of CYBRD1-mediated OV.	Iron	77-81	cytochrome b reductase 1	Homo sapiens	264-270
34547466-8	2022	Since germline knockout of globe SPNS2 showed significantly reduced HCC metastasis, we further developed hepatic-targeting recombinant adeno-associated virus vectors to knockdown SPNS2 expression and to inhibit iron-regulated HCC metastasis.	Iron	211-215	sphingolipid transporter 2	Homo sapiens	33-38
34146930-8	2021	Moreover, six different Fe concentrations (0, 40, 80, 120, 160 and 200 mgL-1) were tested, showing that the addition of 120 mgL-1 had the greatest effect for statistically improving the maximum methane production, with 33% improvement (0.12 +- 0.003 to 0.16 +- 0.012 LCH4 gCODadd-1) compared to no addition of Fe and the specific CH4 production to 0.040 +- 0.001 LCH4 gVS-1.	Iron	24-26	LLGL scribble cell polarity complex component 1	Homo sapiens	124-129
34469685-0	2021	Spin-Pure Stochastic-CASSCF via GUGA-FCIQMC Applied to Iron-Sulfur Clusters.	Iron	55-59	spindlin 1	Homo sapiens	0-4
34469685-3	2021	We apply the method to investigate the spin ladder in iron-sulfur dimer and tetramer model systems.	Iron	54-58	spindlin 1	Homo sapiens	39-43
34575794-2	2021	Among them, some deletion mutants defective in carbon metabolism partially and the MEP2 deletion mutant showed lower iron uptake activity than the wild type.	Iron	117-121	ammonium permease MEP2	Saccharomyces cerevisiae S288C	83-87
34493724-3	2021	The expression of two iron metabolic genes (FPN and LCN2) was selectively knocked down in cancer cells by Cas13a or microRNA controlled by a NF-kappaB-specific promoter.	Iron	22-26	lipocalin 2	Homo sapiens	52-56
34502536-4	2021	Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner.	Iron	61-65	MDM2 proto-oncogene	Homo sapiens	190-194
34502536-4	2021	Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner.	Iron	61-65	cathepsin B	Homo sapiens	328-339
23399021-9	2013	After intravenous administration of transferrin-bound (58) Fe, the amount of (58) Fe incorporated into red blood cells was significantly greater in testosterone-treated mice than in placebo-treated mice.	Iron	82-84	transferrin	Mus musculus	36-47
34114013-7	2021	Iron transporter expression in the placenta was measured by Western blotting, and the expression of Hamp1, the gene encoding the iron regulatory hormone hepcidin, was determined in fetal liver by real-time PCR.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	100-105
34114013-7	2021	Iron transporter expression in the placenta was measured by Western blotting, and the expression of Hamp1, the gene encoding the iron regulatory hormone hepcidin, was determined in fetal liver by real-time PCR.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	153-161
23946721-3	2013	Urine neutrophil gelatinase-associated lipocalin (NGAL), part of an acute response to the release of tissue iron from cells, is an early biomarker and a predictor of AKI in a variety of clinical settings.	Iron	108-112	lipocalin 2	Homo sapiens	6-48
34610701-8	2021	In addition to their roles with steroidogenic mitochondrial P450s, Fdx and FdxR participate in the synthesis of iron-sulfur clusters used by many enzymes.	Iron	112-116	ferredoxin 1	Homo sapiens	67-70
23946721-3	2013	Urine neutrophil gelatinase-associated lipocalin (NGAL), part of an acute response to the release of tissue iron from cells, is an early biomarker and a predictor of AKI in a variety of clinical settings.	Iron	108-112	lipocalin 2	Homo sapiens	50-54
23946721-4	2013	We sought to evaluate the relationship between urine catalytic iron (unbound iron) and NGAL over the course of AKI due to cardiac surgery.	Iron	63-67	lipocalin 2	Homo sapiens	87-91
23946721-4	2013	We sought to evaluate the relationship between urine catalytic iron (unbound iron) and NGAL over the course of AKI due to cardiac surgery.	Iron	77-81	lipocalin 2	Homo sapiens	87-91
34424708-3	2021	To that end, we have developed a ligand platform featuring phosphinimide donors intended to stabilize oxidized, high-spin iron complexes.	Iron	122-126	spindlin 1	Homo sapiens	117-121
34424708-5	2021	Spectroscopic and computational studies of this species support a high-spin Fe(III) center antiferromagnetically coupled to a superoxide ligand, similar to that proposed for numerous nonheme iron oxygenases.	Iron	191-195	spindlin 1	Homo sapiens	71-75
23946721-10	2013	The correlation between baseline levels of urine catalytic iron and NGAL and peak levels of urine catalytic iron and NGAL was r = 0.86, p &lt; 0.0001.	Iron	59-63	lipocalin 2	Homo sapiens	68-72
23946721-10	2013	The correlation between baseline levels of urine catalytic iron and NGAL and peak levels of urine catalytic iron and NGAL was r = 0.86, p &lt; 0.0001.	Iron	59-63	lipocalin 2	Homo sapiens	117-121
23946721-11	2013	CONCLUSION: Urine catalytic iron appears to rise and fall in concert with NGAL in patients undergoing cardiac surgery and may be indicative of early AKI.	Iron	28-32	lipocalin 2	Homo sapiens	74-78
23506888-1	2013	Two families of zinc (Zn(2 +)) transporters are involved in zinc homeostasis in the body, SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, Zinc(Zn(2+))-Iron(Fe(2+)) Permease).	Iron	149-153	death associated protein kinase 3	Homo sapiens	131-134
34289436-2	2021	The chaperone protein succinate dehydrogenase assembly factor 1 (SDHAF1) plays an essential role in the assembly of SDH, and in the incorporation of iron-sulfur clusters into the SDHB subunit.	Iron	149-153	succinate dehydrogenase complex assembly factor 1	Homo sapiens	22-63
34289436-2	2021	The chaperone protein succinate dehydrogenase assembly factor 1 (SDHAF1) plays an essential role in the assembly of SDH, and in the incorporation of iron-sulfur clusters into the SDHB subunit.	Iron	149-153	succinate dehydrogenase complex assembly factor 1	Homo sapiens	65-71
34289436-2	2021	The chaperone protein succinate dehydrogenase assembly factor 1 (SDHAF1) plays an essential role in the assembly of SDH, and in the incorporation of iron-sulfur clusters into the SDHB subunit.	Iron	149-153	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	179-183
23506900-2	2013	Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis.	Iron	182-186	FLVCR heme transporter 1	Homo sapiens	43-49
25166836-2	2013	Ferromagnetic resonance and effective s-d coupling in Ni(80)Fe(20) results in spin accumulation at the Ni(80)Fe(20)/p-Si interface, inducing spin injection and the generation of spin current in the p-Si.	Iron	0-2	spindlin 1	Homo sapiens	78-82
34485112-21	2021	Conclusion: Inhibition of CISD2 promoted sorafenib-induced ferroptosis in resistant cells, and this process promoted excessive iron ion accumulation through autophagy, leading to ferroptosis.	Iron	127-131	CDGSH iron sulfur domain 2	Homo sapiens	26-31
25166836-2	2013	Ferromagnetic resonance and effective s-d coupling in Ni(80)Fe(20) results in spin accumulation at the Ni(80)Fe(20)/p-Si interface, inducing spin injection and the generation of spin current in the p-Si.	Iron	0-2	spindlin 1	Homo sapiens	141-145
34445190-5	2021	Distinguishability of MF from NF may be useful in non-invasive MRI diagnosis of pathological processes associated with iron accumulation and magnetite mineralization (e.g., neurodegenerative disorders, cancer, and diseases of the heart, lung and liver).	Iron	119-123	neurofascin	Homo sapiens	30-32
25166836-2	2013	Ferromagnetic resonance and effective s-d coupling in Ni(80)Fe(20) results in spin accumulation at the Ni(80)Fe(20)/p-Si interface, inducing spin injection and the generation of spin current in the p-Si.	Iron	0-2	spindlin 1	Homo sapiens	141-145
34394834-9	2021	Therefore, our data revealed that highly expressed hepcidin might promote the degradation of FPN1, resulting in neuronal iron deposition, oxidative stress damage, reduced synaptic plasticity, and impaired cognitive performance during CIH exposure.	Iron	121-125	hepcidin antimicrobial peptide	Mus musculus	51-59
25166836-2	2013	Ferromagnetic resonance and effective s-d coupling in Ni(80)Fe(20) results in spin accumulation at the Ni(80)Fe(20)/p-Si interface, inducing spin injection and the generation of spin current in the p-Si.	Iron	60-62	spindlin 1	Homo sapiens	78-82
34181029-1	2021	The liver hormone hepcidin regulates systemic iron homeostasis.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	18-26
25166836-2	2013	Ferromagnetic resonance and effective s-d coupling in Ni(80)Fe(20) results in spin accumulation at the Ni(80)Fe(20)/p-Si interface, inducing spin injection and the generation of spin current in the p-Si.	Iron	60-62	spindlin 1	Homo sapiens	141-145
25166836-2	2013	Ferromagnetic resonance and effective s-d coupling in Ni(80)Fe(20) results in spin accumulation at the Ni(80)Fe(20)/p-Si interface, inducing spin injection and the generation of spin current in the p-Si.	Iron	60-62	spindlin 1	Homo sapiens	141-145
23333832-0	2013	Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload.	Iron	103-107	mitochondrial calcium uniporter	Rattus norvegicus	0-31
34175561-3	2021	Based on Fenton reactions initiated by iron ions, CaO2-supplied H2O2 could not only generate  OH for H2O2-sufficient CDT, but also produce O2 to promote the catalytic efficiency of GOx under hypoxia.	Iron	39-43	hydroxyacid oxidase 1	Homo sapiens	181-184
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	35-37	S100 calcium binding protein A9	Homo sapiens	91-94
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	35-37	S100 calcium binding protein A9	Homo sapiens	191-194
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	80-82	S100 calcium binding protein A9	Homo sapiens	91-94
34442256-5	2021	Tf upregulation is likely to perform a protective role against the Fenton reaction occurring between iron and H2O2 in the antioxidant pathway in the mated queen"s spermathecal fluid.	Iron	101-105	transferrin	Apis mellifera	0-2
34360974-1	2021	Erythropoietin (EPO) downregulates hepcidin expression to increase the availability of iron; the downregulation of hepcidin is mediated by erythroferrone (ERFE) secreted by erythroblasts.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	35-43
23333832-2	2013	We determined the role of mitochondrial calcium uniporter (MCU) in brain mitochondria as a major route for iron entry.	Iron	107-111	mitochondrial calcium uniporter	Rattus norvegicus	26-57
34439408-2	2021	While numerous studies linked beta-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated with hereditary conditions that result in iron overload, e.g., hemochromatosis, Friedreich"s ataxia, and Wolfram syndrome type 2 (WFS-T2; a mutation in CISD2, encoding the (2Fe-2S) protein NAF-1), underscores an additional link between iron metabolism and beta-cell failure.	Iron	184-188	CDGSH iron sulfur domain 2	Homo sapiens	294-299
23333832-2	2013	We determined the role of mitochondrial calcium uniporter (MCU) in brain mitochondria as a major route for iron entry.	Iron	107-111	mitochondrial calcium uniporter	Rattus norvegicus	59-62
34439408-2	2021	While numerous studies linked beta-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated with hereditary conditions that result in iron overload, e.g., hemochromatosis, Friedreich"s ataxia, and Wolfram syndrome type 2 (WFS-T2; a mutation in CISD2, encoding the (2Fe-2S) protein NAF-1), underscores an additional link between iron metabolism and beta-cell failure.	Iron	378-382	CDGSH iron sulfur domain 2	Homo sapiens	294-299
23333832-3	2013	We hypothesized that iron overload causes brain mitochondrial dysfunction, and that the MCU blocker prevents iron entry into mitochondria, thus attenuating mitochondrial dysfunction.	Iron	109-113	mitochondrial calcium uniporter	Rattus norvegicus	88-91
34975249-8	2021	Factor 1 comprised mainly of markers of anemia, iron metabolism, and erythropoiesis and was related to "erythrocyte health status," while factor 2 comprised mainly markers of inflammation and iron metabolism and was related to "acute phase reactants."	Iron	192-196	transcription termination factor 2	Homo sapiens	138-146
23333832-10	2013	SIGNIFICANCE: Our findings indicated that iron overload caused brain mitochondrial dysfunction, and that an MCU blocker effectively prevented this impairment, suggesting that MCU could be the major portal for brain mitochondrial iron uptake.	Iron	42-46	mitochondrial calcium uniporter	Rattus norvegicus	175-178
23333832-10	2013	SIGNIFICANCE: Our findings indicated that iron overload caused brain mitochondrial dysfunction, and that an MCU blocker effectively prevented this impairment, suggesting that MCU could be the major portal for brain mitochondrial iron uptake.	Iron	229-233	mitochondrial calcium uniporter	Rattus norvegicus	108-111
23333832-10	2013	SIGNIFICANCE: Our findings indicated that iron overload caused brain mitochondrial dysfunction, and that an MCU blocker effectively prevented this impairment, suggesting that MCU could be the major portal for brain mitochondrial iron uptake.	Iron	229-233	mitochondrial calcium uniporter	Rattus norvegicus	175-178
22614012-3	2013	Functionally, LCN2 has a number of different activities that may contribute to its oncogenic potential, including increasing matrix metalloproteinase activity, control of iron availability and stimulating inflammation.	Iron	171-175	lipocalin 2	Homo sapiens	14-18
22614012-7	2013	We found that this increase was correlated to tumor iron(II) content, suggesting that an iron-scavenging role is important for LCN2 oncogenic activity in the intestine.	Iron	52-56	lipocalin 2	Homo sapiens	127-131
23315731-0	2013	The iron-dependent regulator fur controls pheromone signaling systems and luminescence in the squid symbiont Vibrio fischeri ES114.	Iron	4-8	fur	Vibrio fischeri ES114	29-32
23315731-7	2013	This iron-dependent effect on luminescence required ferric uptake regulator (Fur), which we propose influences two pheromone signaling master regulators, LitR and LuxR.	Iron	5-9	fur	Vibrio fischeri ES114	77-80
23315731-8	2013	Genetic and bioinformatic analyses suggested that under low-iron conditions, Fur-mediated repression of litR is relieved, enabling more LitR to perform its established role as an activator of luxR.	Iron	60-64	fur	Vibrio fischeri ES114	77-80
23363304-10	2013	On the contrary, PEG-8-L incorporation into magnetoliposomes promoted a decrease of average diameter and a lower PEG-8-L incorporation percentage as a result of reduction on the fluidity of the bilayer imparted by iron incorporation into the lipid structure.	Iron	214-218	IGF2 antisense RNA	Homo sapiens	17-22
23307650-8	2013	Expression pattern analyses of the central oscillator genes in mutants defective in CIRCADIAN CLOCK ASSOCIATED1/LATE ELONGATED HYPOCOTYL or GIGANTEA demonstrated their requirement for Fe deficiency-induced long circadian period.	Iron	184-186	Homeodomain-like superfamily protein	Arabidopsis thaliana	112-136
23223430-1	2013	Mutations in HFE lead to hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepatic expression of the iron-regulatory hormone hepcidin.	Iron	89-93	homeostatic iron regulator	Mus musculus	13-16
23223430-5	2013	In the present study, we demonstrate that LNP-Tmprss6 siRNA treatment of Hfe(-/-) and Hbb(th3/+) mice induces hepcidin and diminishes tissue and serum iron levels.	Iron	151-155	homeostatic iron regulator	Mus musculus	73-76
23223430-5	2013	In the present study, we demonstrate that LNP-Tmprss6 siRNA treatment of Hfe(-/-) and Hbb(th3/+) mice induces hepcidin and diminishes tissue and serum iron levels.	Iron	151-155	hemoglobin beta chain complex	Mus musculus	86-89
23223430-7	2013	Our results indicate that pharmacologic manipulation of Tmprss6 with RNAi therapeutics isa practical approach to treating iron overload diseases associated with diminished hepcidin expression and may have efficacy in modifying disease-associated morbidities of -thalassemia intermedia.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	172-180
23420358-0	2013	SRAP analysis of DNA base sequence changes in lotus mutants induced by Fe+ implantation.	Iron	71-74	steroid receptor RNA activator 1	Homo sapiens	0-4
23301870-4	2013	The concentrations of iron were found to be ~25% for Chm and ~12% for GO-Chm.	Iron	22-26	CHM Rab escort protein	Homo sapiens	53-56
23301870-4	2013	The concentrations of iron were found to be ~25% for Chm and ~12% for GO-Chm.	Iron	22-26	CHM Rab escort protein	Homo sapiens	73-76
23395173-2	2013	We report here that mice with targeted deletion of Irp1 developed pulmonary hypertension and polycythemia that was exacerbated by a low-iron diet.	Iron	136-140	aconitase 1	Mus musculus	51-55
23395174-0	2013	The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	Iron	37-41	aconitase 1	Mus musculus	4-8
23395174-0	2013	The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	Iron	85-89	aconitase 1	Mus musculus	4-8
23395174-5	2013	Expression of the iron transport genes DCytb, Dmt1, and ferroportin, as well as other HIF-2alpha targets, is enhanced in Irp1(-/-) duodenum.	Iron	18-22	aconitase 1	Mus musculus	121-125
23395174-6	2013	Analysis of mRNA translation state in the liver revealed IRP1-dependent dysregulation of HIF-2alpha mRNA translation, whereas IRP2 deficiency derepressed translation of all other known 5" iron response element (IRE)-containing mRNAs expressed in the liver.	Iron	188-192	iron responsive element binding protein 2	Mus musculus	126-130
23174565-5	2013	The current study was thus designed to decipher mechanistic aspects of Atp7a regulation during iron deprivation using an established in vitro model of the mammalian intestine, rat intestinal epithelial (IEC-6) cells.	Iron	95-99	ATPase copper transporting alpha	Homo sapiens	71-76
23453014-12	2013	A further novel process of DNA repair discovered by my research group is the action of AlkB as an iron-dependent enzyme carrying out oxidative demethylation.	Iron	98-102	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	87-91
23299425-2	2013	As well, an Fe-S cluster scaffold protein, ISU, might alter the incorporation of Fe or Mn into yeast MnSOD (ySOD2), thus leading to active or inactive ySOD2.	Iron	12-14	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	108-113
23299425-2	2013	As well, an Fe-S cluster scaffold protein, ISU, might alter the incorporation of Fe or Mn into yeast MnSOD (ySOD2), thus leading to active or inactive ySOD2.	Iron	12-14	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	151-156
23178912-7	2013	Expression levels of mitoferrin 1 and 2, frataxin, and iron-sulfur cluster scaffold protein were also significantly increased in G93A-SOD1 cells, suggesting higher mitochondrial iron import and utilization in biosynthetic pathways within the mitochondria.	Iron	178-182	solute carrier family 25 member 37	Homo sapiens	21-39
23269600-1	2013	OBJECTIVE: To assess the frequency of mutations in C19orf12 in the greater neurodegeneration with brain iron accumulation (NBIA) population and further characterize the associated phenotype.	Iron	104-108	chromosome 19 open reading frame 12	Homo sapiens	51-59
23135267-0	2013	Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy.	Iron	37-41	solute carrier family 25 member 28	Homo sapiens	0-12
23135267-2	2013	Here, we investigated whether mitochondrial iron uptake through mitoferrin-2 (Mfrn2) enhanced PDT-induced cell killing.	Iron	44-48	solute carrier family 25 member 28	Homo sapiens	64-76
23135267-2	2013	Here, we investigated whether mitochondrial iron uptake through mitoferrin-2 (Mfrn2) enhanced PDT-induced cell killing.	Iron	44-48	solute carrier family 25 member 28	Homo sapiens	78-83
23135267-11	2013	Taken together, the data suggest that lysosomal iron release and Mfrn2-dependent mitochondrial iron uptake act synergistically to induce PDT-mediated and iron-dependent mitochondrial dysfunction and subsequent cell killing.	Iron	95-99	solute carrier family 25 member 28	Homo sapiens	65-70
23135267-11	2013	Taken together, the data suggest that lysosomal iron release and Mfrn2-dependent mitochondrial iron uptake act synergistically to induce PDT-mediated and iron-dependent mitochondrial dysfunction and subsequent cell killing.	Iron	95-99	solute carrier family 25 member 28	Homo sapiens	65-70
23135277-1	2013	Maintenance of cellular iron homeostasis requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2).	Iron	24-28	iron responsive element binding protein 2	Mus musculus	110-135
23135277-1	2013	Maintenance of cellular iron homeostasis requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2).	Iron	24-28	iron responsive element binding protein 2	Mus musculus	137-141
23135277-1	2013	Maintenance of cellular iron homeostasis requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2).	Iron	85-89	iron responsive element binding protein 2	Mus musculus	110-135
23135277-1	2013	Maintenance of cellular iron homeostasis requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2).	Iron	85-89	iron responsive element binding protein 2	Mus musculus	137-141
23135277-2	2013	The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and facilitates IRP2 degradation in iron replete cells.	Iron	119-123	iron responsive element binding protein 2	Mus musculus	164-168
23135277-2	2013	The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and facilitates IRP2 degradation in iron replete cells.	Iron	184-188	iron responsive element binding protein 2	Mus musculus	164-168
30271428-4	2013	Genetic control of mineral composition in common bean seed was demonstrated by large (p&lt;0.01) genotypic differences in Ca and Sr contents and moderate genotypic difference was observed in Fe content.	Iron	191-193	brain expressed associated with NEDD4 1	Homo sapiens	49-53
33536353-1	2021	Background: Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin-25 are involved in catalytic iron-related kidney injury after cardiac surgery with cardiopulmonary bypass.	Iron	104-108	lipocalin 2	Homo sapiens	12-54
33536353-1	2021	Background: Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin-25 are involved in catalytic iron-related kidney injury after cardiac surgery with cardiopulmonary bypass.	Iron	104-108	lipocalin 2	Homo sapiens	56-60
22960056-0	2013	Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.	Iron	66-70	hepcidin antimicrobial peptide	Mus musculus	38-46
34154707-0	2021	Novel roles of HIF-PHIs in chronic kidney disease: the link between iron metabolism, kidney function, and FGF23.	Iron	68-72	fibroblast growth factor 23	Mus musculus	106-111
34155415-3	2021	Mice deficient in hepcidin specifically in the colon tumour epithelium, compared with wild-type littermates, exhibit significantly diminished tumour number, burden and size in a sporadic model of CRC, whereas accumulation of intracellular iron by deletion of the iron exporter ferroportin exacerbates these tumour parameters.	Iron	239-243	hepcidin antimicrobial peptide	Mus musculus	18-26
34155415-3	2021	Mice deficient in hepcidin specifically in the colon tumour epithelium, compared with wild-type littermates, exhibit significantly diminished tumour number, burden and size in a sporadic model of CRC, whereas accumulation of intracellular iron by deletion of the iron exporter ferroportin exacerbates these tumour parameters.	Iron	263-267	hepcidin antimicrobial peptide	Mus musculus	18-26
22960056-1	2013	The inhibitory Smad7 acts as a critical suppressor of hepcidin, the major regulator of systemic iron homeostasis.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	54-62
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	45-49	homeostatic iron regulator	Mus musculus	63-66
34145762-2	2021	Ascertaining that, metal-organic-framework-derived freestanding, defect-rich, and in situ oxidized Fe-Co-O/Co metal@N-doped carbon (Co@NC) mesoporous nanosheet (mNS) heterostructure on Ni foam (Fe-Co-O/Co@NC-mNS/NF) is developed from the in situ oxidation of micropillar-like heterostructured Fe-Co-O/Co@NC/NF precatalyst.	Iron	99-101	neurofascin	Homo sapiens	212-214
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	45-49	homeostatic iron regulator	Mus musculus	74-77
34145762-2	2021	Ascertaining that, metal-organic-framework-derived freestanding, defect-rich, and in situ oxidized Fe-Co-O/Co metal@N-doped carbon (Co@NC) mesoporous nanosheet (mNS) heterostructure on Ni foam (Fe-Co-O/Co@NC-mNS/NF) is developed from the in situ oxidation of micropillar-like heterostructured Fe-Co-O/Co@NC/NF precatalyst.	Iron	99-101	neurofascin	Homo sapiens	307-309
34145762-2	2021	Ascertaining that, metal-organic-framework-derived freestanding, defect-rich, and in situ oxidized Fe-Co-O/Co metal@N-doped carbon (Co@NC) mesoporous nanosheet (mNS) heterostructure on Ni foam (Fe-Co-O/Co@NC-mNS/NF) is developed from the in situ oxidation of micropillar-like heterostructured Fe-Co-O/Co@NC/NF precatalyst.	Iron	194-196	neurofascin	Homo sapiens	212-214
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	45-49	transferrin receptor 2	Mus musculus	78-82
34145762-2	2021	Ascertaining that, metal-organic-framework-derived freestanding, defect-rich, and in situ oxidized Fe-Co-O/Co metal@N-doped carbon (Co@NC) mesoporous nanosheet (mNS) heterostructure on Ni foam (Fe-Co-O/Co@NC-mNS/NF) is developed from the in situ oxidation of micropillar-like heterostructured Fe-Co-O/Co@NC/NF precatalyst.	Iron	194-196	neurofascin	Homo sapiens	307-309
34145762-3	2021	The in situ oxidized Fe-Co-O/Co@NC-mNS/NF exhibits excellent bifunctional properties by demanding only low overpotentials of 257 and 112 mV, respectively, for OER and HER at the current density of 10 mA cm-2 , with long-term durability, attributed to the existence of oxygen vacancies, higher specific surface area, increased electrochemical active surface area, and in situ generated new metal (oxyhydr)oxide phases.	Iron	21-23	neurofascin	Homo sapiens	39-41
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	148-156
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	125-129	homeostatic iron regulator	Mus musculus	63-66
22960056-4	2013	This regulatory circuitry is disconnected by iron treatment of Hfe-/- and Hfe/TfR2 mice that significantly increases hepatic iron levels as well as hepcidin, Smad6 and Smad7 mRNA expression but fails to augment pSmad1/5/8 levels.	Iron	125-129	homeostatic iron regulator	Mus musculus	74-77
22847740-0	2013	Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	35-43
34193175-8	2021	To test the effect of mutation of the substrate binding-site residues on PfVIT function a yeast complementation assay assessed the ability of overexpressed, recombinant wild type and mutant PfVIT to rescue an iron-sensitive deletion strain (ccc1 ) of Saccharomyces cerevisiae yeast from the toxic effects of a high concentration of extracellular iron.	Iron	209-213	Ccc1p	Saccharomyces cerevisiae S288C	241-245
34193175-8	2021	To test the effect of mutation of the substrate binding-site residues on PfVIT function a yeast complementation assay assessed the ability of overexpressed, recombinant wild type and mutant PfVIT to rescue an iron-sensitive deletion strain (ccc1 ) of Saccharomyces cerevisiae yeast from the toxic effects of a high concentration of extracellular iron.	Iron	346-350	Ccc1p	Saccharomyces cerevisiae S288C	241-245
22847740-0	2013	Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	35-43
22847740-1	2013	The iron regulatory hormone hepcidin responds to both oral and parenteral iron.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	28-36
22847740-1	2013	The iron regulatory hormone hepcidin responds to both oral and parenteral iron.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	28-36
34161397-11	2021	We conclude that hepatocellular iron overload suppresses hepcidin by inhibiting the SMAD and STAT3 signaling pathways downstream of their respective ligands.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	57-65
22847740-2	2013	Here, we hypothesized that the diverse iron trafficking routes may affect the dynamics and kinetics of the hepcidin activation pathway.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	107-115
22847740-5	2013	After 1 week of dietary loading with carbonyl iron, mice exhibited significant increases in serum iron and transferrin saturation, as well as in hepatic iron, Smad1/5/8 phosphorylation and bone morphogenetic protein 6 (BMP6), and hepcidin mRNAs.	Iron	46-50	transferrin	Mus musculus	107-118
34162370-0	2021	Fe-doped chrysotile nanotubes containing siRNAs to silence SPAG5 to treat bladder cancer.	Iron	0-2	sperm associated antigen 5	Homo sapiens	59-64
22847740-5	2013	After 1 week of dietary loading with carbonyl iron, mice exhibited significant increases in serum iron and transferrin saturation, as well as in hepatic iron, Smad1/5/8 phosphorylation and bone morphogenetic protein 6 (BMP6), and hepcidin mRNAs.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	230-238
34203091-0	2021	An Internal Promoter Drives the Expression of a Truncated Form of CCC1 Capable of Protecting Yeast from Iron Toxicity.	Iron	104-108	Ccc1p	Saccharomyces cerevisiae S288C	66-70
22847740-9	2013	Our data suggest that the physiological hepcidin response is saturable and are consistent with the idea that hepcidin senses exclusively iron compartmentalized within circulating transferrin and/or hepatocytes.	Iron	137-141	hepcidin antimicrobial peptide	Mus musculus	40-48
34203091-1	2021	In yeast, iron storage and detoxification depend on the Ccc1 transporter that mediates iron accumulation in vacuoles.	Iron	10-14	Ccc1p	Saccharomyces cerevisiae S288C	56-60
34203091-1	2021	In yeast, iron storage and detoxification depend on the Ccc1 transporter that mediates iron accumulation in vacuoles.	Iron	87-91	Ccc1p	Saccharomyces cerevisiae S288C	56-60
22847740-9	2013	Our data suggest that the physiological hepcidin response is saturable and are consistent with the idea that hepcidin senses exclusively iron compartmentalized within circulating transferrin and/or hepatocytes.	Iron	137-141	hepcidin antimicrobial peptide	Mus musculus	109-117
34203091-2	2021	While deletion of the CCC1 gene renders cells unable to survive under iron overload conditions, the deletion of its previously identified regulators only partially affects survival, indicating that the mechanisms controlling iron storage and detoxification in yeast are still far from well understood.	Iron	225-229	Ccc1p	Saccharomyces cerevisiae S288C	22-26
34203091-5	2021	s-Ccc1, though less efficiently than Ccc1, is able to promote metal accumulation in the vacuole, protecting cells against iron toxicity.	Iron	122-126	Ccc1p	Saccharomyces cerevisiae S288C	2-6
22847740-9	2013	Our data suggest that the physiological hepcidin response is saturable and are consistent with the idea that hepcidin senses exclusively iron compartmentalized within circulating transferrin and/or hepatocytes.	Iron	137-141	transferrin	Mus musculus	179-190
34203091-5	2021	s-Ccc1, though less efficiently than Ccc1, is able to promote metal accumulation in the vacuole, protecting cells against iron toxicity.	Iron	122-126	Ccc1p	Saccharomyces cerevisiae S288C	37-41
34203091-6	2021	While the expression of the s-Ccc1 appears to be repressed in the normal genomic context, our current data clearly demonstrates that it is functional and has the capacity to play a role under iron overload conditions.	Iron	192-196	Ccc1p	Saccharomyces cerevisiae S288C	30-34
22854109-0	2013	High-fat, high-fructose diet induces hepatic iron overload via a hepcidin-independent mechanism prior to the onset of liver steatosis and insulin resistance in mice.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	65-73
23533686-8	2013	Therefore, the deleterious effects of HO-1 expression in this in vivo neuroinflammatory model were linked to a hyperproduction of ROS, itself promoted by free iron liberation.	Iron	159-163	heme oxygenase 1	Rattus norvegicus	38-42
34199599-2	2021	Transferrin receptor 2 (TFR2), a carrier protein for transferrin, is involved in hepatic iron overload in alcoholic liver disease (ALD).	Iron	89-93	transferrin receptor 2	Mus musculus	0-22
34199599-2	2021	Transferrin receptor 2 (TFR2), a carrier protein for transferrin, is involved in hepatic iron overload in alcoholic liver disease (ALD).	Iron	89-93	transferrin receptor 2	Mus musculus	24-28
34199599-2	2021	Transferrin receptor 2 (TFR2), a carrier protein for transferrin, is involved in hepatic iron overload in alcoholic liver disease (ALD).	Iron	89-93	transferrin	Mus musculus	53-64
24130505-9	2013	We were able to successfully validate this novel approach by identifying mutants that dissociate the conserved interaction between Cia2 and Mms19, two proteins involved in Iron-Sulfur protein biogenesis and genome stability.	Iron	172-176	iron-sulfur cluster assembly protein CIA2	Saccharomyces cerevisiae S288C	131-135
34071287-3	2021	In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms.	Iron	112-116	heme oxygenase 1	Rattus norvegicus	14-18
34071361-3	2021	The replacement of iron with cobalt as the metal center of protoporphyrin IX changes the ligand from an agonist to an antagonist of REV-ERBbeta.	Iron	19-23	thyroid hormone receptor alpha	Homo sapiens	136-143
34064225-2	2021	This disorder is produced by mutations in the iron responsive element (IRE) located in the 5" untranslated regions (UTR) of the light ferritin (FTL) gene.	Iron	46-50	ferritin light chain	Homo sapiens	144-147
24130505-9	2013	We were able to successfully validate this novel approach by identifying mutants that dissociate the conserved interaction between Cia2 and Mms19, two proteins involved in Iron-Sulfur protein biogenesis and genome stability.	Iron	172-176	Met18p	Saccharomyces cerevisiae S288C	140-145
34063414-2	2021	The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	12-20
23580874-0	2013	Comments on: "Impact of iron overload on interleukin-10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia".	Iron	24-28	interleukin 10	Homo sapiens	41-55
34063414-3	2021	In the genetic, iron-loading disorder hereditary hemochromatosis (HH), hepcidin production is low and Fpn1 protein expression is elevated.	Iron	16-20	hepcidin antimicrobial peptide	Mus musculus	71-79
34065122-4	2021	Total iron content was estimated by a colourimetric FerroZine  assay in presence or absence of transferrin-bound iron.	Iron	113-117	transferrin	Mus musculus	95-106
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	215-217	H3 clustered histone 4	Homo sapiens	223-226
23580881-0	2013	Impact of iron overload on interleukin-10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia.	Iron	10-14	interleukin 10	Homo sapiens	27-41
23580881-1	2013	OBJECTIVE: The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients.	Iron	63-67	interleukin 10	Homo sapiens	95-109
23580881-10	2013	The Iron overload Group showed lower interleukin-10 levels and catalase activity and higher nitrite and malondialdehyde levels compared with the Non-iron overload Group.	Iron	4-8	interleukin 10	Homo sapiens	37-51
35605547-4	2022	The Fe/N-GR electrochemical biosensor achieves an ultra-low detection limit for DA of 27 pM with a linear range of 50 pM-15 nM.	Iron	4-6	reticulon 4 receptor	Homo sapiens	7-11
23095756-3	2012	Human EXO5 (hEXO5) contains an iron-sulfur cluster.	Iron	31-35	exonuclease 5	Homo sapiens	6-10
35605547-5	2022	Specifically, the Fe/N-GR electrochemical biosensor exhibits favorable sensitivity and enzyme-level molecular identification ability in the selective detection of DA versus other typical redox-active interferents.	Iron	18-20	reticulon 4 receptor	Homo sapiens	21-25
35439490-0	2022	Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity.	Iron	63-67	general transcription factor IIE subunit 1	Homo sapiens	69-71
23095756-3	2012	Human EXO5 (hEXO5) contains an iron-sulfur cluster.	Iron	31-35	exonuclease 5	Homo sapiens	12-17
23099055-0	2012	NGP1-01, a multi-targeted polycyclic cage amine, attenuates brain endothelial cell death in iron overload conditions.	Iron	92-96	G protein nucleolar 2	Homo sapiens	0-4
35636333-3	2022	In this study, Fe depletion significantly inhibited the growth, photosynthesis, Fe accumulation level and the enzyme activity of Fe-S proteins of aconitase (ACO), nitrate reductase (NiR) and succinate dehydrogenase (SDH) in strawberry seedlings.	Iron	15-17	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	216-219
35445828-8	2022	Next, we validated the efficacy of NBMI in Hfe H67D mutant mice, a mouse model of brain iron accumulation (BIA).	Iron	88-92	homeostatic iron regulator	Mus musculus	43-46
23099055-6	2012	We demonstrate here that NGP1-01 (1 and 10muM) pretreatment abrogates the effects of iron overload in brain endothelial cells protecting cellular viability.	Iron	85-89	G protein nucleolar 2	Homo sapiens	25-29
23099055-7	2012	Both concentrations of NGP1-01 were found to attenuate iron-induced reduction in cellular viability to a similar extent, and were statistically significant.	Iron	55-59	G protein nucleolar 2	Homo sapiens	23-27
23099055-9	2012	Addition of NGP1-01 dose-dependently reduced FPL 64176 stimulated uptake of iron.	Iron	76-80	G protein nucleolar 2	Homo sapiens	12-16
23099055-10	2012	These data support further evaluation of NGP1-01 as a neuroprotective agent, not only in diseases associated with excitotoxicity, but also in those of iron overload.	Iron	151-155	G protein nucleolar 2	Homo sapiens	41-45
23123111-6	2012	In the complex, the conserved cysteines of HypC and HypD form an Fe binding site.	Iron	65-67	pre-mRNA processing factor 40 homolog B	Homo sapiens	43-47
35512597-1	2022	BACKGROUND & AIMS: Previous experimental studies demonstrated that either deficient or excessive trace elements, such as manganese (Mn), iron (Fe), copper (Cu) and selenium (Se), are detrimental to bone health.	Iron	137-141	general transcription factor IIE subunit 1	Homo sapiens	143-145
35239084-3	2022	METHODS: We determined the relationship between maternal iron and vitamin A status at delivery using several biomarkers (ferritin, soluble transferrin receptor (sTFR), body iron stores (BIS), hemoglobin and retinol binding protein (RBP)) and birth outcomes (body weight, Z-scores, head circumference, small-for-gestational-age and preterm birth) in rural Uganda.	Iron	57-61	retinol binding protein 4	Homo sapiens	207-230
35239084-3	2022	METHODS: We determined the relationship between maternal iron and vitamin A status at delivery using several biomarkers (ferritin, soluble transferrin receptor (sTFR), body iron stores (BIS), hemoglobin and retinol binding protein (RBP)) and birth outcomes (body weight, Z-scores, head circumference, small-for-gestational-age and preterm birth) in rural Uganda.	Iron	57-61	retinol binding protein 4	Homo sapiens	232-235
23123111-6	2012	In the complex, the conserved cysteines of HypC and HypD form an Fe binding site.	Iron	65-67	MAGE family member A3	Homo sapiens	52-56
22773607-0	2012	CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients.	Iron	41-45	cytochrome b reductase 1	Homo sapiens	0-6
35447365-3	2022	The ferroptosis is mainly regulated by the metabolism of iron, lipids and amino acids through System Xc-, voltage-dependent anion channels, p53, p62-Keap1-Nrf2, mevalonate and other pathways.	Iron	57-61	nucleoporin 62	Homo sapiens	145-148
35593209-4	2022	Like PICOT, yeast Grx3 and Grx4 reside in the cytosol and nucleus where they form unusual Fe-S clusters coordinated by two glutaredoxins with CGFS motifs and two molecules of glutathione.	Iron	90-92	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	18-22
35593209-5	2022	Depletion or deletion of Grx3/Grx4 leads to functional impairment of virtually all cellular iron-dependent processes and loss of cell viability, thus making these genes the most upstream components of the iron utilization system.	Iron	92-96	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	25-29
35593209-5	2022	Depletion or deletion of Grx3/Grx4 leads to functional impairment of virtually all cellular iron-dependent processes and loss of cell viability, thus making these genes the most upstream components of the iron utilization system.	Iron	205-209	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	25-29
22444869-2	2012	Hepcidin is a key regulator of iron metabolism and may be responsible for obesity-driven iron deficiency.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	0-8
35445268-8	2022	Loss of IRON MAN /FE-UPTAKE-INDUCING PEPTIDE (IMA/FEP) leads to the disruption of compensatory upregulation of IRT1 in the root surrounded by sufficient iron.	Iron	153-157	iron-regulated transporter 1	Arabidopsis thaliana	111-115
22444869-7	2012	Neither hepatic and adipose tissue nor serum hepcidin concentrations differed significantly between SD- and HFD-fed mice, whereas dietary iron supplementation resulted in increased hepatic hepcidin mRNA expression and serum hepcidin levels in SD as compared to HFD mice.	Iron	138-142	hepcidin antimicrobial peptide	Mus musculus	189-197
35568031-5	2022	Through genome-wide association study, we identify associations between spleen iron and regulatory variation at two hereditary spherocytosis genes, ANK1 and SPTA1.	Iron	79-83	ankyrin 1	Homo sapiens	148-152
22444869-7	2012	Neither hepatic and adipose tissue nor serum hepcidin concentrations differed significantly between SD- and HFD-fed mice, whereas dietary iron supplementation resulted in increased hepatic hepcidin mRNA expression and serum hepcidin levels in SD as compared to HFD mice.	Iron	138-142	hepcidin antimicrobial peptide	Mus musculus	189-197
35568031-5	2022	Through genome-wide association study, we identify associations between spleen iron and regulatory variation at two hereditary spherocytosis genes, ANK1 and SPTA1.	Iron	79-83	spectrin alpha, erythrocytic 1	Homo sapiens	157-162
23045394-0	2012	Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	33-38
23045394-0	2012	Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression.	Iron	115-119	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	33-38
23045394-1	2012	Aft1p is an iron-responsive transcriptional activator that plays a central role in the regulation of iron metabolism in Saccharomyces cerevisiae.	Iron	12-16	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
35426179-1	2022	Randomised control trials (RCTs) have shown that certain intravenous iron preparations can induce high levels of FGF-23 and persistent hypophosphatemia.	Iron	69-73	fibroblast growth factor 23	Homo sapiens	113-119
23045394-1	2012	Aft1p is an iron-responsive transcriptional activator that plays a central role in the regulation of iron metabolism in Saccharomyces cerevisiae.	Iron	101-105	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
23045394-2	2012	Aft1p is regulated by accelerated nuclear export in the presence of iron, mediated by Msn5p.	Iron	68-72	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
23045394-3	2012	However, the transcriptional activity of Aft1p is suppressed under iron-replete conditions in the Deltamsn5 strain, although Aft1p remains in the nucleus.	Iron	67-71	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	41-46
35229270-9	2022	In addition, Rg1 maintained the iron-regulated protein homeostasis by increasing the expression of ferritin heavy chain and decreasing ferritin light chain in oligodendrocytes, especially the mature oligodendrocytes (OLs).	Iron	32-36	ferritin heavy polypeptide 1	Mus musculus	99-119
23045394-4	2012	Aft1p dissociates from its target promoters under iron-replete conditions due to an interaction between Aft1p and the monothiol glutaredoxin Grx3p or Grx4p (Grx3/4p).	Iron	50-54	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
35575503-10	2022	Furthermore, the recycling of siderophores by the MmpL-MmpS4/5 orchestra provides endogenous drug targets to beat the bugs with iron-toxicity contrivance.	Iron	128-132	proteolipid protein 1	Homo sapiens	50-54
23045394-4	2012	Aft1p dissociates from its target promoters under iron-replete conditions due to an interaction between Aft1p and the monothiol glutaredoxin Grx3p or Grx4p (Grx3/4p).	Iron	50-54	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	104-109
23045394-4	2012	Aft1p dissociates from its target promoters under iron-replete conditions due to an interaction between Aft1p and the monothiol glutaredoxin Grx3p or Grx4p (Grx3/4p).	Iron	50-54	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	141-146
23045394-4	2012	Aft1p dissociates from its target promoters under iron-replete conditions due to an interaction between Aft1p and the monothiol glutaredoxin Grx3p or Grx4p (Grx3/4p).	Iron	50-54	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	157-164
35614551-9	2022	Iron in the nigra increased with disease duration (PDE > PDDN (P = 0.001), PDM > PDE (P = 0.045)) except for PDM versus PDL (P = 0.226).	Iron	0-4	aldehyde dehydrogenase 7 family member A1	Homo sapiens	51-54
35614551-9	2022	Iron in the nigra increased with disease duration (PDE > PDDN (P = 0.001), PDM > PDE (P = 0.045)) except for PDM versus PDL (P = 0.226).	Iron	0-4	aldehyde dehydrogenase 7 family member A1	Homo sapiens	81-84
23045394-5	2012	The binding of Grx3/4p to Aft1p is induced by iron repletion and requires binding of an iron-sulfur cluster to Grx3/4p.	Iron	46-50	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	15-22
23045394-5	2012	The binding of Grx3/4p to Aft1p is induced by iron repletion and requires binding of an iron-sulfur cluster to Grx3/4p.	Iron	46-50	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	26-31
23045394-5	2012	The binding of Grx3/4p to Aft1p is induced by iron repletion and requires binding of an iron-sulfur cluster to Grx3/4p.	Iron	88-92	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	15-22
23045394-5	2012	The binding of Grx3/4p to Aft1p is induced by iron repletion and requires binding of an iron-sulfur cluster to Grx3/4p.	Iron	88-92	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	26-31
23045394-5	2012	The binding of Grx3/4p to Aft1p is induced by iron repletion and requires binding of an iron-sulfur cluster to Grx3/4p.	Iron	88-92	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	111-118
35584228-4	2022	First, a variant that disrupted the primary iron (Fe) uptake transporter gene (IRT1) swept quickly to fixation in a hard selective sweep, increasing Mn but limiting Fe in the leaves.	Iron	44-48	iron-regulated transporter 1	Arabidopsis thaliana	79-83
22321247-1	2012	The peptide hormone hepcidin functions as a negative regulator of intestinal Fe absorption and Fe recycling.	Iron	77-79	hepcidin antimicrobial peptide	Mus musculus	20-28
35304126-8	2022	Furthermore, forward and reverse validation experiments demonstrated that six-transmembrane epithelial antigen of prostate 3 (STEAP3), a new interacting molecule for ISCA1, plays an important role in iron metabolism and energy generation impairment induced by ISCA1 deficiency.	Iron	200-204	iron-sulfur cluster assembly 1	Rattus norvegicus	166-171
35631204-10	2022	Additionally, decreased activities of glutathione peroxidase and catalase, and increased cleaved-caspase 8 and caspase 3 expression, were found in the iron-deficient rats.	Iron	151-155	caspase 8	Rattus norvegicus	97-106
22321247-1	2012	The peptide hormone hepcidin functions as a negative regulator of intestinal Fe absorption and Fe recycling.	Iron	95-97	hepcidin antimicrobial peptide	Mus musculus	20-28
22321247-2	2012	Since its discovery as a systemic negative regulator of Fe metabolism, hepcidin has attracted enormous interest as a potential drug for the treatment and/or prevention of several forms of Fe overload.	Iron	56-58	hepcidin antimicrobial peptide	Mus musculus	71-79
22321247-2	2012	Since its discovery as a systemic negative regulator of Fe metabolism, hepcidin has attracted enormous interest as a potential drug for the treatment and/or prevention of several forms of Fe overload.	Iron	188-190	hepcidin antimicrobial peptide	Mus musculus	71-79
35551594-3	2022	Chemical analysis of 78 GW samples revealed significantly high As (max 0.12 mgL-1, mean 0.02 mgL-1) followed by iron (max 62.2 mgL-1, mean 19.94 mgL-1) showing uneven distribution.	Iron	112-116	LLGL scribble cell polarity complex component 1	Homo sapiens	127-132
22321247-3	2012	We therefore tested whether multiple doses of intraperitoneally administered synthetic renatured hepcidin can prevent hepatic Fe loading in mice concurrently fed an Fe-rich diet, and whether the same treatment affects hepatic Fe stores in mice fed a normal diet.	Iron	126-128	hepcidin antimicrobial peptide	Mus musculus	97-105
35551594-3	2022	Chemical analysis of 78 GW samples revealed significantly high As (max 0.12 mgL-1, mean 0.02 mgL-1) followed by iron (max 62.2 mgL-1, mean 19.94 mgL-1) showing uneven distribution.	Iron	112-116	LLGL scribble cell polarity complex component 1	Homo sapiens	145-150
23159058-3	2012	Examining this interplay during malaria, the disease caused by Plasmodium infection, we find that expression of the Fe sequestering protein ferritin H chain (FtH) in mice, and ferritin in humans, is associated with reduced tissue damage irrespectively of pathogen burden.	Iron	116-118	ferritin heavy polypeptide 1	Mus musculus	140-156
35631165-1	2022	This study aimed to explore the role of the single nucleotide polymorphism (SNP) rs516946 of the Ankyrin 1 (ANK1) gene in the relationship between dietary iron and metabolic syndrome (MetS) in the Chinese population.	Iron	155-159	ankyrin 1	Homo sapiens	97-106
35631165-1	2022	This study aimed to explore the role of the single nucleotide polymorphism (SNP) rs516946 of the Ankyrin 1 (ANK1) gene in the relationship between dietary iron and metabolic syndrome (MetS) in the Chinese population.	Iron	155-159	ankyrin 1	Homo sapiens	108-112
35631165-8	2022	ANK1 SNP rs516946 interacted in the association of MetS with dietary iron among Chinese males while no association was found among females.	Iron	69-73	ankyrin 1	Homo sapiens	0-4
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	thioredoxin 1	Mus musculus	220-223
35631174-8	2022	Iron overload inhibited the increase in the expression of NF-kappaB and its downstream inflammatory cytokines (IL-6, TNFalpha, iNOS, COX2, and IL-1beta), likely due to the elevated expression of antioxidant genes (SOD1, TXN, GPX1, GPX4, CAT, HMOX1, and NQO1).	Iron	0-4	NAD(P)H dehydrogenase, quinone 1	Mus musculus	253-257
23159058-3	2012	Examining this interplay during malaria, the disease caused by Plasmodium infection, we find that expression of the Fe sequestering protein ferritin H chain (FtH) in mice, and ferritin in humans, is associated with reduced tissue damage irrespectively of pathogen burden.	Iron	116-118	ferritin heavy polypeptide 1	Mus musculus	158-161
23159058-4	2012	FtH protection relies on its ferroxidase activity, which prevents labile Fe from sustaining proapoptotic c-Jun N-terminal kinase (JNK) activation.	Iron	73-75	ferritin heavy polypeptide 1	Mus musculus	0-3
35566389-4	2022	Since iron releases from heme as a consequence of HO-1 activity, we hypothesized that the application of an iron-chelator (IC) would reverse the lost cardiac protection associated with an elevated HO-1 level.	Iron	6-10	heme oxygenase 1	Rattus norvegicus	50-54
35566389-4	2022	Since iron releases from heme as a consequence of HO-1 activity, we hypothesized that the application of an iron-chelator (IC) would reverse the lost cardiac protection associated with an elevated HO-1 level.	Iron	6-10	heme oxygenase 1	Rattus norvegicus	197-201
35566389-4	2022	Since iron releases from heme as a consequence of HO-1 activity, we hypothesized that the application of an iron-chelator (IC) would reverse the lost cardiac protection associated with an elevated HO-1 level.	Iron	108-112	heme oxygenase 1	Rattus norvegicus	197-201
23159058-4	2012	FtH protection relies on its ferroxidase activity, which prevents labile Fe from sustaining proapoptotic c-Jun N-terminal kinase (JNK) activation.	Iron	73-75	mitogen-activated protein kinase 8	Mus musculus	105-128
23159058-4	2012	FtH protection relies on its ferroxidase activity, which prevents labile Fe from sustaining proapoptotic c-Jun N-terminal kinase (JNK) activation.	Iron	73-75	mitogen-activated protein kinase 8	Mus musculus	130-133
35525219-7	2022	Mechanistically, CdTe QDs-provoked decrease of nuclear factor erythroid 2-related factor 2 (NRF2) elicited phosphorylation of extracellular regulated protein kinases1/2 (ERK1/2) and then activated ferritinophagy, which made ferritin heavy chain 1 (FTH1) degraded in lysosome and proteasome to release free iron ions to initiate ferroptosis in macrophages.	Iron	306-310	ferritin heavy polypeptide 1	Mus musculus	224-246
35525219-7	2022	Mechanistically, CdTe QDs-provoked decrease of nuclear factor erythroid 2-related factor 2 (NRF2) elicited phosphorylation of extracellular regulated protein kinases1/2 (ERK1/2) and then activated ferritinophagy, which made ferritin heavy chain 1 (FTH1) degraded in lysosome and proteasome to release free iron ions to initiate ferroptosis in macrophages.	Iron	306-310	ferritin heavy polypeptide 1	Mus musculus	248-252
23159058-5	2012	FtH expression is inhibited by JNK activation, promoting tissue Fe overload, tissue damage, and malaria severity.	Iron	64-66	ferritin heavy polypeptide 1	Mus musculus	0-3
23159058-7	2012	Thus, FtH provides metabolic adaptation to tissue Fe overload, conferring tolerance to malaria.	Iron	50-52	ferritin heavy polypeptide 1	Mus musculus	6-9
23159059-0	2012	Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism.	Iron	111-115	lipocalin 2	Homo sapiens	0-11
23159059-3	2012	We determined that Lipocalin 2 (Lcn2), a host protein that sequesters iron, is abundantly secreted during human (P. vivax) and mouse (P. yoeliiNL) blood-stage malaria infections and is essential to control P. yoeliiNL parasitemia, anemia, and host survival.	Iron	70-74	lipocalin 2	Homo sapiens	19-30
35504898-8	2022	Mechanistically, we found that de-O-GlcNAcylation of the ferritin heavy chain at S179 promoted its interaction with NCOA4, the ferritinophagy receptor, thereby accumulating labile iron for ferroptosis.	Iron	180-184	nuclear receptor coactivator 4	Homo sapiens	116-121
23159059-3	2012	We determined that Lipocalin 2 (Lcn2), a host protein that sequesters iron, is abundantly secreted during human (P. vivax) and mouse (P. yoeliiNL) blood-stage malaria infections and is essential to control P. yoeliiNL parasitemia, anemia, and host survival.	Iron	70-74	lipocalin 2	Homo sapiens	32-36
35490179-2	2022	Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis.	Iron	69-73	iron responsive element binding protein 2	Mus musculus	0-25
35490179-2	2022	Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis.	Iron	69-73	iron responsive element binding protein 2	Mus musculus	27-31
23159059-6	2012	Thus, Lcn2 exerts antiparasitic effects by maintaining iron homeostasis and promoting innate and adaptive immune responses.	Iron	55-59	lipocalin 2	Homo sapiens	6-10
35490179-4	2022	Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the cytoplasm, de-polyubiquitylates, and stabilizes IRP2 protein in an iron-independent manner.	Iron	190-194	iron responsive element binding protein 2	Mus musculus	90-94
22851198-9	2012	Simultaneously, increased CD163 expression in lepromatous cells seemed to be dependent on ML uptake, and contributed to augmented iron storage in lepromatous macrophages.	Iron	130-134	CD163 molecule	Homo sapiens	26-31
35490179-4	2022	Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the cytoplasm, de-polyubiquitylates, and stabilizes IRP2 protein in an iron-independent manner.	Iron	190-194	iron responsive element binding protein 2	Mus musculus	111-115
35490179-4	2022	Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for IRP2, interacts with IRP2 in the cytoplasm, de-polyubiquitylates, and stabilizes IRP2 protein in an iron-independent manner.	Iron	190-194	iron responsive element binding protein 2	Mus musculus	171-175
35548676-4	2022	The Fe complex exhibits cleavage ability toward pBR322 DNA, and the crystal structure of the HSA Fe complex adduct at 2.4 A resolution clearly shows that His288 serves as the axial ligand of the Fe center complexed with a pentadentate DPA-Bpy ligand.	Iron	4-6	translocator protein	Homo sapiens	48-51
35548676-4	2022	The Fe complex exhibits cleavage ability toward pBR322 DNA, and the crystal structure of the HSA Fe complex adduct at 2.4 A resolution clearly shows that His288 serves as the axial ligand of the Fe center complexed with a pentadentate DPA-Bpy ligand.	Iron	97-99	translocator protein	Homo sapiens	48-51
35548676-4	2022	The Fe complex exhibits cleavage ability toward pBR322 DNA, and the crystal structure of the HSA Fe complex adduct at 2.4 A resolution clearly shows that His288 serves as the axial ligand of the Fe center complexed with a pentadentate DPA-Bpy ligand.	Iron	195-197	translocator protein	Homo sapiens	48-51
22591204-9	2012	The HFD with iron synergistically induced mRNA expression of Pparalpha targets, including Acox and Cpt1 in wild-type mice, yet the induction was diminished in Nrf2-null mice.	Iron	13-17	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	90-94
35461329-3	2022	As expected, ferric citrate lowered serum phosphate concentrations and increased serum iron levels in the Col4alpha3 knockout mice.	Iron	87-91	collagen, type IV, alpha 3	Mus musculus	106-116
22591204-10	2012	Hepatic hepcidin and ferroportin 1 mRNA expression were increased in wild-type mice after feeding a HFD with iron, but were unchanged in any group of Nrf2-null mice.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	8-16
35414480-1	2022	Remarkable progress has been made in dissecting the molecular mechanisms involved in iron (Fe) homeostasis in plants, especially the identification of key transporter and transcriptional regulatory networks.	Iron	85-89	general transcription factor IIE subunit 1	Homo sapiens	91-93
23018275-6	2012	We found that SufB(2)C(2) was most proficient as a scaffold for de novo assembly of holo-Fdx using sulfide and iron as freely available building blocks while SufA was best at direct transfer of a pre-formed FeS cluster to Fdx.	Iron	111-115	ferredoxin 1	Homo sapiens	89-92
35396390-6	2022	Meanwhile, the circulating level of fibroblast growth factor-23-a factor known to reduce serum iron and intestinal calcium absorption-was increased early in young BKO-MPA mice.	Iron	95-99	fibroblast growth factor 23	Mus musculus	36-63
22578638-9	2012	The results indicated that the iucB gene related virulence factors including the iron assimilation system were important for the pathogenesis of APEC E058.	Iron	81-85	IucB	Escherichia coli	31-35
35290040-8	2022	This resulted in the dissolution and loss of 47.2 +- 20.3% of initial Fe(III) (oxyhydr)oxides when conditions are wetter and more reduced, and new formation of Fe(III) minerals (33.7 +- 8.6% gain in comparison to initial Fe) in the late summer under more dry and oxic conditions, which also led to the sequestration of Fe-bound organic carbon.	Iron	221-223	general transcription factor IIE subunit 1	Homo sapiens	160-167
35290040-8	2022	This resulted in the dissolution and loss of 47.2 +- 20.3% of initial Fe(III) (oxyhydr)oxides when conditions are wetter and more reduced, and new formation of Fe(III) minerals (33.7 +- 8.6% gain in comparison to initial Fe) in the late summer under more dry and oxic conditions, which also led to the sequestration of Fe-bound organic carbon.	Iron	319-321	general transcription factor IIE subunit 1	Homo sapiens	160-167
35433479-12	2022	In HEY cells, provided with a high intracellular labile iron pool, erastin treatment is accompanied by NCOA4-mediated ferritinophagy and mitochondrial dysfunction, thus triggering ferroptosis.	Iron	56-60	nuclear receptor coactivator 4	Homo sapiens	103-108
35433479-15	2022	Notably, the use of ferlixit sensitizes COV318 cells to erastin through a NCOA4-independent intracellular iron accumulation and mitochondrial dysfunction.	Iron	106-110	nuclear receptor coactivator 4	Homo sapiens	74-79
22578638-11	2012	These results suggested that the single gene either iucB or iutA was likely to be involved directly or indirectly in iron uptake for the pathogenicity of APEC E058, and there was an obviously synergistic effect between iucB and iutA genes on the pathogenicity of APEC E058.	Iron	117-121	IucB	Escherichia coli	52-56
22578638-11	2012	These results suggested that the single gene either iucB or iutA was likely to be involved directly or indirectly in iron uptake for the pathogenicity of APEC E058, and there was an obviously synergistic effect between iucB and iutA genes on the pathogenicity of APEC E058.	Iron	117-121	IucB	Escherichia coli	219-223
34982827-0	2022	Lysosomal iron recycling in mouse macrophages is dependent upon both reductases LcytB and Steap3.	Iron	10-14	STEAP family member 3	Mus musculus	90-96
23091275-4	2012	Thus, two iron-sulfur clusters - the hallmark feature of ABCE1 - help catalyze an integral step of the translational cycle at the core of the protein synthesis machinery.	Iron	10-14	ATP binding cassette subfamily E member 1	Homo sapiens	57-62
34982827-3	2022	Here we report that the lysosomal reductase Cyb561a3 (LcytB) and the endosomal reductase Six-transmembrane epithelial antigen of the prostate 3 (Steap3) act as lysosomal ferrireductases in the mouse macrophage cell line RAW264.7 converting Fe3+ to Fe2+ for iron recycling.	Iron	257-261	STEAP family member 3	Mus musculus	145-151
22548729-9	2012	Using a combination of Hb, MCV and CHr, we increased the stringency to identify truly iron-deficient postpartum anemic women, thereby reducing unnecessary iron supplementation in those women with sufficient iron stores.	Iron	86-90	chromate resistance; sulfate transport	Homo sapiens	35-38
35294743-0	2022	Plasma Non-transferrin-Bound Iron Could Enter into Mice Duodenum and Negatively Affect Duodenal Defense Response to Virus and Immune Responses.	Iron	29-33	transferrin	Mus musculus	11-22
35294743-1	2022	Plasma non-transferrin-bound iron (NTBI) exists when the plasma iron content exceeds the carrying capacity of transferrin and can be quickly cleared by the liver, pancreas, and other organs.	Iron	29-33	transferrin	Mus musculus	11-22
35294743-1	2022	Plasma non-transferrin-bound iron (NTBI) exists when the plasma iron content exceeds the carrying capacity of transferrin and can be quickly cleared by the liver, pancreas, and other organs.	Iron	29-33	transferrin	Mus musculus	110-121
22548729-9	2012	Using a combination of Hb, MCV and CHr, we increased the stringency to identify truly iron-deficient postpartum anemic women, thereby reducing unnecessary iron supplementation in those women with sufficient iron stores.	Iron	155-159	chromate resistance; sulfate transport	Homo sapiens	35-38
35294743-1	2022	Plasma non-transferrin-bound iron (NTBI) exists when the plasma iron content exceeds the carrying capacity of transferrin and can be quickly cleared by the liver, pancreas, and other organs.	Iron	64-68	transferrin	Mus musculus	11-22
35294743-1	2022	Plasma non-transferrin-bound iron (NTBI) exists when the plasma iron content exceeds the carrying capacity of transferrin and can be quickly cleared by the liver, pancreas, and other organs.	Iron	64-68	transferrin	Mus musculus	110-121
22955522-5	2012	Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, ALK, CIAO1, NOTCH3 in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference method and our programming.	Iron	136-140	GDP-L-fucose synthase	Homo sapiens	196-201
35309058-3	2022	Although several papers report the presence of iron deficiency anemia in about 50% of EPP patients, there is still no a conclusive explanation of the why this occurs.	Iron	47-51	ferrochelatase	Homo sapiens	86-89
35309058-8	2022	The mechanisms involved in the iron uptake downregulation in EPP remain unclear, and the role of PPIX accumulation in microcytosis.	Iron	31-35	ferrochelatase	Homo sapiens	61-64
22955522-5	2012	Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, ALK, CIAO1, NOTCH3 in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference method and our programming.	Iron	136-140	ALK receptor tyrosine kinase	Homo sapiens	203-206
22955522-5	2012	Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, ALK, CIAO1, NOTCH3 in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference method and our programming.	Iron	136-140	cytosolic iron-sulfur assembly component 1	Homo sapiens	208-213
23100449-1	2012	Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron.	Iron	253-257	lipocalin 2	Homo sapiens	0-42
34995689-0	2022	Disruption of Hfe leads to skeletal muscle iron loading and reduction of hemoproteins involved in oxidative metabolism in a mouse model of hereditary hemochromatosis.	Iron	43-47	homeostatic iron regulator	Mus musculus	14-17
34997963-0	2022	The (2Fe-2S) protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes.	Iron	58-62	CDGSH iron sulfur domain 2	Mus musculus	21-26
34997963-2	2022	Here we show that cardiomyocytes from CISD2-null mice accumulate high levels of iron and contain high levels of transferrin receptor and ferritin.	Iron	80-84	CDGSH iron sulfur domain 2	Mus musculus	38-43
35038358-5	2022	Consistently, the rescue effects of dZIP13 OE or Tsf1 RNAi on Pink1 RNAi can be inhibited by decreasing the iron levels in mitochondria through mitoferrin (dmfrn) RNAi.	Iron	108-112	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	36-42
35038358-6	2022	This study suggests that dZIP13, Tsf1 and dmfrn might act independently of parkin in a parallel pathway downstream of Pink1 by modulating respiration and indicates that manipulation of iron levels in mitochondria may provide a novel therapeutic strategy for PD associated with Pink1.	Iron	185-189	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	25-31
34993553-5	2022	On the other hand, biofortification of wheat for essential nutrients, such as zinc (Zn) and iron (Fe), is also an objective in wheat improvement programs to tackle micronutrient deficiency.	Iron	92-96	general transcription factor IIE subunit 1	Homo sapiens	98-100
35194137-1	2022	Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC).	Iron	44-48	hemojuvelin BMP co-receptor	Mus musculus	0-11
35194137-1	2022	Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC).	Iron	44-48	hemojuvelin BMP co-receptor	Mus musculus	13-16
35194137-1	2022	Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC).	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	57-65
35194137-1	2022	Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC).	Iron	92-96	hemojuvelin BMP co-receptor	Mus musculus	0-11
35194137-1	2022	Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC).	Iron	92-96	hemojuvelin BMP co-receptor	Mus musculus	13-16
35194137-1	2022	Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC).	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	57-65
35137432-2	2022	We find that by either modulating the electronic effects of a generic iron-catalyst by a set of ligands, that is, CO, BF, PH3 , BN(CH3 )2 , or by manipulating structural effects through the introduction of bidentate ligands, that is, PH2 (CH2 )n PH2 with n = 6-1, one can significantly decrease the reaction barrier for the C X bond activation.	Iron	70-74	polyhomeotic homolog 2	Homo sapiens	234-237
35137432-2	2022	We find that by either modulating the electronic effects of a generic iron-catalyst by a set of ligands, that is, CO, BF, PH3 , BN(CH3 )2 , or by manipulating structural effects through the introduction of bidentate ligands, that is, PH2 (CH2 )n PH2 with n = 6-1, one can significantly decrease the reaction barrier for the C X bond activation.	Iron	70-74	polyhomeotic homolog 2	Homo sapiens	246-249
35158317-4	2022	Further studies showed that the transcriptional levels of iron-uptake related genes IRT1, FRO2, AHA2, FIT and bHLH38 in mutants were significantly higher than in WT under iron deficiency.	Iron	58-62	iron-regulated transporter 1	Arabidopsis thaliana	84-88
35158317-4	2022	Further studies showed that the transcriptional levels of iron-uptake related genes IRT1, FRO2, AHA2, FIT and bHLH38 in mutants were significantly higher than in WT under iron deficiency.	Iron	58-62	H[+]-ATPase 2	Arabidopsis thaliana	96-100
35158317-4	2022	Further studies showed that the transcriptional levels of iron-uptake related genes IRT1, FRO2, AHA2, FIT and bHLH38 in mutants were significantly higher than in WT under iron deficiency.	Iron	58-62	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	110-116
35204767-0	2022	6-Hydroxydopamine Induces Abnormal Iron Sequestration in BV2 Microglia by Activating Iron Regulatory Protein 1 and Inhibiting Hepcidin Release.	Iron	35-39	aconitase 1	Mus musculus	85-110
35204767-3	2022	In this study, we observed that 6-hydroxydopamine (6-OHDA) induced the expression of divalent metal transporter-1 (DMT1) and iron influx in BV2 microglia cells, which might be associated with the upregulation of iron regulatory protein 1 (IRP1) expression.	Iron	125-129	aconitase 1	Mus musculus	212-237
35204767-6	2022	Interestingly, iron overloading suppressed IRP1 expression, thus downregulating DMT1 and upregulating FPN1 levels in these microglial cells.	Iron	15-19	aconitase 1	Mus musculus	43-47
35204767-7	2022	On the contrary, iron deficiency activated IRP1, leading to increased expression of DMT1 and decreased expression of FPN1-which indicates that activated IRP1 induces iron overloading in 6-OHDA-treated microglia, but not iron overloading modulates the expression of IRP1.	Iron	166-170	aconitase 1	Mus musculus	153-157
35204767-8	2022	Taken together, our data suggest that 6-OHDA can regulate the expression of DMT1 and FPN1 by activating IRP1 and inhibiting hepcidin release, thus leading to abnormal iron sequestration in microglia.	Iron	167-171	aconitase 1	Mus musculus	104-108
35204767-8	2022	Taken together, our data suggest that 6-OHDA can regulate the expression of DMT1 and FPN1 by activating IRP1 and inhibiting hepcidin release, thus leading to abnormal iron sequestration in microglia.	Iron	167-171	hepcidin antimicrobial peptide	Mus musculus	124-132
34320783-1	2022	Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only membrane channel that facilitates export of iron from within cells.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	0-8
34320783-1	2022	Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only membrane channel that facilitates export of iron from within cells.	Iron	130-134	hepcidin antimicrobial peptide	Mus musculus	0-8
35163276-2	2022	The iron regulatory hormone hepcidin, produced by renal distal tubules, is suggested to exert a renoprotective role during this pathology.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	28-36
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	hepcidin antimicrobial peptide	Mus musculus	29-37
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	NAD(P)H dehydrogenase, quinone 1	Mus musculus	264-268
35163276-5	2022	Moreover, iron/heme-mediated hepcidin induction in mCCDcl1 cells was caused by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as indicated by increased nuclear Nrf2 translocation and induced expression of Nrf2 downstream targets GCLM (p < 0.001), NQO1 (p < 0.001), and TXNRD1 (p < 0.005), which could be prevented by the known Nrf2 inhibitor trigonelline.	Iron	10-14	thioredoxin reductase 1	Mus musculus	286-292
35075211-0	2022	M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling.	Iron	54-58	colony stimulating factor 1 (macrophage)	Mus musculus	0-5
35075211-0	2022	M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling.	Iron	124-128	colony stimulating factor 1 (macrophage)	Mus musculus	0-5
35075211-3	2022	Instead, M-CSF blockade further impaired erythropoiesis and erythroid cells access to iron.	Iron	86-90	colony stimulating factor 1 (macrophage)	Mus musculus	9-14
35075211-4	2022	M-CSF blockade enhanced inflammatory cytokine secretion, further increased systemic neutrophil counts, and led to tissue iron sequestration that was dependent, in part, on augmented IL-6 secretion which induced hepcidin.	Iron	121-125	colony stimulating factor 1 (macrophage)	Mus musculus	0-5
35075211-5	2022	Deleterious effects of post burn M-CSF blockade were associated with arrest of an iron recycling gene expression signature in the liver and spleen that included Spi-C transcription factor and heme oxygenase-1, which promote heme metabolism and confer a non-inflammatory tone in macrophages.	Iron	82-86	colony stimulating factor 1 (macrophage)	Mus musculus	33-38
35075211-5	2022	Deleterious effects of post burn M-CSF blockade were associated with arrest of an iron recycling gene expression signature in the liver and spleen that included Spi-C transcription factor and heme oxygenase-1, which promote heme metabolism and confer a non-inflammatory tone in macrophages.	Iron	82-86	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	161-166
35075211-7	2022	Together, this data indicates M-CSF secretion supports a homeostatic iron recycling program that plays a key role in the maintenance of erythroid cells access to iron following burn injury.	Iron	69-73	colony stimulating factor 1 (macrophage)	Mus musculus	30-35
35208164-9	2022	Under iron-rich diet, the protein expression of ATP4A was increased and serum, hepatic and gastric hepcidin were all induced.	Iron	6-10	ATPase H+/K+ transporting subunit alpha	Homo sapiens	48-53
35014607-0	2022	Aging is associated with increased brain iron through cortex-derived hepcidin expression.	Iron	41-45	hepcidin antimicrobial peptide	Mus musculus	69-77
35014607-5	2022	This increase in brain iron is associated with elevated levels of local hepcidin mRNA and protein in the brain.	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	72-80
35014607-6	2022	We also demonstrate that the increase in hepcidin is associated with increased ubiquitination and reduced levels of the only iron exporter, ferroportin-1 (FPN1).	Iron	125-129	hepcidin antimicrobial peptide	Mus musculus	41-49
35014607-7	2022	Overall, our studies provide a potential mechanism for iron accumulation in the brain through increased local expression of hepcidin, and subsequent iron accumulation due to decreased iron export.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	124-132
34997531-3	2022	In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB.	Iron	168-172	RoBo-1	Rattus norvegicus	65-93
34997531-3	2022	In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB.	Iron	168-172	RoBo-1	Rattus norvegicus	95-99
34997531-6	2022	After 15 min of 1 mg iron loading, the fluorescence intensity of duodenal DMT1 in iron-deficient rats was decreased and was comparable to that in iron-sufficient rats.	Iron	21-25	RoBo-1	Rattus norvegicus	74-78
34997531-6	2022	After 15 min of 1 mg iron loading, the fluorescence intensity of duodenal DMT1 in iron-deficient rats was decreased and was comparable to that in iron-sufficient rats.	Iron	82-86	RoBo-1	Rattus norvegicus	74-78
34997531-7	2022	Internalized DMT1-IRE as puncta was observed at 15 and 60 min after 1 mg iron loading, and the number of punctas was significantly increased after 60 min compared with control.	Iron	73-77	RoBo-1	Rattus norvegicus	13-17
34997531-9	2022	Our results suggest that the decrease and internalization of DMT1-IRE protein may be related, at least in part, to iron uptake suppression in SAMB.	Iron	115-119	RoBo-1	Rattus norvegicus	61-65
35008976-5	2022	Here we identify for the first time the important role of Tbeta4 mechanism in ferroptosis, an iron-dependent form of cell death, which leads to neurodegeneration and somehow protects cancer cells against cell death.	Iron	94-98	thymosin beta-4	Bos taurus	58-64
35008976-8	2022	We state the hypothesis that Tbeta4 is an endogenous iron chelator and take part in iron homeostasis in the ferroptosis process.	Iron	53-57	thymosin beta-4	Bos taurus	29-35
35121990-4	2022	Mechanistically, we demonstrate that ENO1, as an RNA-binding protein, recruits CNOT6 to accelerate the messenger RNA decay of IRP1 in cancer cells, leading to inhibition of mitoferrin-1 (Mfrn1) expression and subsequent repression of mitochondrial iron-induced ferroptosis.	Iron	248-252	CCR4-NOT transcription complex subunit 6	Homo sapiens	79-84
35121990-4	2022	Mechanistically, we demonstrate that ENO1, as an RNA-binding protein, recruits CNOT6 to accelerate the messenger RNA decay of IRP1 in cancer cells, leading to inhibition of mitoferrin-1 (Mfrn1) expression and subsequent repression of mitochondrial iron-induced ferroptosis.	Iron	248-252	solute carrier family 25 member 37	Homo sapiens	187-192
23100449-1	2012	Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron.	Iron	253-257	lipocalin 2	Homo sapiens	44-48
21696386-7	2012	It validates the important role of Arg386 and therefore supports the current molecular model of iron-sulfur clusters in NDUFV1.	Iron	96-100	NADH:ubiquinone oxidoreductase core subunit V1	Homo sapiens	120-126
22610607-0	2012	Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis.	Iron	50-54	hepcidin antimicrobial peptide	Mus musculus	76-84
22610607-5	2012	Concurrently, the plasma concentration of hepcidin, the key regulator in iron metabolism, and hepatic hepcidin antimicrobial peptide (Hamp) mRNA expression levels were significantly reduced.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	42-50
22609087-1	2012	Hepcidin, an iron regulatory peptide, plays a central role in the maintenance of systemic iron homeostasis by inducing the internalization and degradation of the iron exporter, ferroportin.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	0-8
22609087-1	2012	Hepcidin, an iron regulatory peptide, plays a central role in the maintenance of systemic iron homeostasis by inducing the internalization and degradation of the iron exporter, ferroportin.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	0-8
22609087-1	2012	Hepcidin, an iron regulatory peptide, plays a central role in the maintenance of systemic iron homeostasis by inducing the internalization and degradation of the iron exporter, ferroportin.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	0-8
22609087-2	2012	Hepcidin expression in the liver is regulated in response to several stimuli including iron status, erythropoietic activity, hypoxia and inflammation.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	0-8
22609087-4	2012	In this mouse model, hepcidin suppression was associated with increased expression of molecules involved in iron transport and recycling.	Iron	108-112	hepcidin antimicrobial peptide	Mus musculus	21-29
22609087-14	2012	This observation may be caused by the absence of hepcidin per se or the altered iron homeostasis induced by the lack of hepcidin in these mice.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	120-128
22658830-3	2012	Compared with Fe(3)O(4) nanoparticle-H(2)O(2) system, NOF degradation in Fe(3)O(4)@AlG/Fe-H(2)O(2) system can be conducted in a wide pH range (pH 3.5-6.5) and independent on temperature.	Iron	14-16	mitochondrial ribosomal protein L49	Homo sapiens	54-57
22847425-0	2012	Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster.	Iron	53-57	Multicopper oxidase 1	Drosophila melanogaster	0-21
22847425-5	2012	We identified candidate iron-binding residues in the MCO1 sequence and found that purified recombinant MCO1 oxidizes ferrous iron.	Iron	24-28	Multicopper oxidase 1	Drosophila melanogaster	53-57
22847425-5	2012	We identified candidate iron-binding residues in the MCO1 sequence and found that purified recombinant MCO1 oxidizes ferrous iron.	Iron	24-28	Multicopper oxidase 1	Drosophila melanogaster	103-107
22847425-5	2012	We identified candidate iron-binding residues in the MCO1 sequence and found that purified recombinant MCO1 oxidizes ferrous iron.	Iron	125-129	Multicopper oxidase 1	Drosophila melanogaster	103-107
22847425-6	2012	An association between MCO1 function and iron homeostasis was confirmed by two observations: RNAi-mediated knockdown of MCO1 resulted in decreased iron accumulation in midguts and whole insects, and weak knockdown increased the longevity of flies fed a toxic concentration of iron.	Iron	41-45	Multicopper oxidase 1	Drosophila melanogaster	23-27
22847425-6	2012	An association between MCO1 function and iron homeostasis was confirmed by two observations: RNAi-mediated knockdown of MCO1 resulted in decreased iron accumulation in midguts and whole insects, and weak knockdown increased the longevity of flies fed a toxic concentration of iron.	Iron	41-45	Multicopper oxidase 1	Drosophila melanogaster	120-124
22847425-6	2012	An association between MCO1 function and iron homeostasis was confirmed by two observations: RNAi-mediated knockdown of MCO1 resulted in decreased iron accumulation in midguts and whole insects, and weak knockdown increased the longevity of flies fed a toxic concentration of iron.	Iron	147-151	Multicopper oxidase 1	Drosophila melanogaster	23-27
22847425-6	2012	An association between MCO1 function and iron homeostasis was confirmed by two observations: RNAi-mediated knockdown of MCO1 resulted in decreased iron accumulation in midguts and whole insects, and weak knockdown increased the longevity of flies fed a toxic concentration of iron.	Iron	147-151	Multicopper oxidase 1	Drosophila melanogaster	120-124
22847425-6	2012	An association between MCO1 function and iron homeostasis was confirmed by two observations: RNAi-mediated knockdown of MCO1 resulted in decreased iron accumulation in midguts and whole insects, and weak knockdown increased the longevity of flies fed a toxic concentration of iron.	Iron	147-151	Multicopper oxidase 1	Drosophila melanogaster	23-27
22847425-6	2012	An association between MCO1 function and iron homeostasis was confirmed by two observations: RNAi-mediated knockdown of MCO1 resulted in decreased iron accumulation in midguts and whole insects, and weak knockdown increased the longevity of flies fed a toxic concentration of iron.	Iron	147-151	Multicopper oxidase 1	Drosophila melanogaster	120-124
22847425-9	2012	We propose that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.	Iron	38-42	Multicopper oxidase 1	Drosophila melanogaster	16-20
22659878-9	2012	However, in contrast to the role of NQO1 in vitro, we demonstrate that NE-treated Nqo1-null mice had greater levels of BAL and lung tissue lipid carbonyls and greater BAL iron on day 11, all consistent with increased oxidative stress.	Iron	171-175	NAD(P)H dehydrogenase, quinone 1	Mus musculus	82-86
22476617-9	2012	HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions.	Iron	34-36	mitofusin 2	Homo sapiens	194-199
22383097-13	2012	CONCLUSION: Disruption of both Hfe and Tfr2 caused more severe hepatic iron overload with more advanced lipid peroxidation, inflammation, and portal fibrosis than was observed with the disruption of either gene alone.	Iron	71-75	homeostatic iron regulator	Mus musculus	31-34
22383097-13	2012	CONCLUSION: Disruption of both Hfe and Tfr2 caused more severe hepatic iron overload with more advanced lipid peroxidation, inflammation, and portal fibrosis than was observed with the disruption of either gene alone.	Iron	71-75	transferrin receptor 2	Mus musculus	39-43
22383097-14	2012	The Hfe(-/-) xTfr2(mut) mouse model of iron-induced liver injury reflects the liver injury phenotype observed in human HH.	Iron	39-43	homeostatic iron regulator	Mus musculus	4-7
22739376-7	2012	Dopamine (DA) receptor D1 was upregulated in the hippocampus of Fe+DHA/EPA rats (fold-change = 1.25; P &lt; 0.05) and there were significant Fe x DHA/EPA interactions on serotonin (5-HT) in the OB and on the DA metabolite dihydroxyphenylacetic acid in the FC and striatum.	Iron	64-66	dopamine receptor D1	Rattus norvegicus	0-25
22810756-4	2012	If these results are confirmed in a larger population, ARC and CHr could be considered affordable and widely available markers to detect early responders to oral iron therapy, and to switch unresponsive children to parenteral iron supplementation or transfusion.	Iron	162-166	chromate resistance; sulfate transport	Homo sapiens	63-66
22634302-5	2012	RT-PCR method showed that iron treatment specifically increased the levels of eIF3A mRNA and La mRNA, whereas iron chelation reduced them.	Iron	26-30	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	78-83
22634302-6	2012	Western blots also confirmed that iron-dependent changes in eIF3A mRNA and La mRNA affected the expression of their proteins.	Iron	34-38	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	60-65
22634302-7	2012	Moreover, antisense phosphorothioate oligodeoxynucleotides to eIF3A and La successfully suppressed the levels of eIF3A and La protein and significantly reduced iron-dependent HCV translation.	Iron	160-164	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	62-67
22634302-7	2012	Moreover, antisense phosphorothioate oligodeoxynucleotides to eIF3A and La successfully suppressed the levels of eIF3A and La protein and significantly reduced iron-dependent HCV translation.	Iron	160-164	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	113-118
22634302-8	2012	Taken together, our results suggest that iron promotes the translation initiation of HCV by stimulating the expression of eIF3A and La proteins.	Iron	41-45	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	122-127
22678361-3	2012	Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18.	Iron	69-73	cytosolic iron-sulfur protein assembly 1	Mus musculus	98-103
22678362-4	2012	MMS19 functions as part of the CIA targeting complex that specifically interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance.	Iron	102-106	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	0-5
22766337-11	2012	RESULTS: In Hp2-2 plaques, iron content was increased (1.22 +- 0.15 vs. 0.54 +- 0.08; p &lt; 0.0001) along with expression of oxidized phospholipid- (78.9 +- 5.8 vs. 38.8 +- 3.8; p &lt; 0.0001), and malondialdehyde-like OSEs (93.9 +- 7.9 vs. 54.7 +- 3.9; p &lt; 0.0001).	Iron	27-31	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	12-17
22681596-3	2012	The main function of ferritin is to oxidize the cytotoxic Fe(2+) ions and store the oxidized Fe in the inner cavity.	Iron	58-60	DVU1568	Desulfovibrio vulgaris str. Hildenborough	21-29
22681596-5	2012	In bacterial ferritins, however, X-ray crystallographic evidence and amino acid sequence analysis revealed a trinuclear Fe binding center comprising a binuclear Fe binding center (sites A and B), homologous to the ferroxidase center of H-type ferritin, and an adjacent mononuclear Fe binding site (site C).	Iron	120-122	DVU1568	Desulfovibrio vulgaris str. Hildenborough	13-21
22681596-5	2012	In bacterial ferritins, however, X-ray crystallographic evidence and amino acid sequence analysis revealed a trinuclear Fe binding center comprising a binuclear Fe binding center (sites A and B), homologous to the ferroxidase center of H-type ferritin, and an adjacent mononuclear Fe binding site (site C).	Iron	161-163	DVU1568	Desulfovibrio vulgaris str. Hildenborough	13-21
22681596-5	2012	In bacterial ferritins, however, X-ray crystallographic evidence and amino acid sequence analysis revealed a trinuclear Fe binding center comprising a binuclear Fe binding center (sites A and B), homologous to the ferroxidase center of H-type ferritin, and an adjacent mononuclear Fe binding site (site C).	Iron	161-163	DVU1568	Desulfovibrio vulgaris str. Hildenborough	13-21
22681596-6	2012	In an effort to obtain further evidence supporting the presence of a trinuclear Fe binding center in bacterial ferritins and to gain information on the states of the iron bound to the trinuclear center, bacterial ferritin from Desulfovibrio vulgaris (DvFtn) and its E130A variant was loaded with substoichiometric amounts of Fe(2+), and the products were characterized by Mossbauer and EPR spectroscopy.	Iron	80-82	DVU1568	Desulfovibrio vulgaris str. Hildenborough	111-119
22616905-1	2012	As the transport protein for iron, transferrin can trigger cellular endocytosis once binding to its receptor (TfR) on the cell membrane.	Iron	29-33	transferrin	Mus musculus	35-46
22278715-1	2012	UNLABELLED: The hepatic peptide hormone hepcidin controls the duodenal absorption of iron, its storage, and its systemic distribution.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	40-48
22278715-2	2012	Hepcidin production is often insufficient in chronic hepatitis C and alcoholic liver disease, leading to hyperabsorption of iron and its accumulation in the liver.	Iron	124-128	hepcidin antimicrobial peptide	Mus musculus	0-8
22278715-10	2012	EGF, HGF, and possibly other growth factors that activate similar pathways may contribute to hepcidin suppression in chronic liver diseases, promote iron accumulation in the liver, and exacerbate the destructive disease processes.	Iron	149-153	hepatocyte growth factor	Mus musculus	5-8
22851944-7	2012	Laboratory examinations showed that serum iron and zinc levels in workers" with the ALAD 1-2 genotype were higher than those with the ALAD 1-1 genotype, especially in storage-battery workers.	Iron	42-46	aminolevulinate dehydratase	Homo sapiens	84-88
22851944-7	2012	Laboratory examinations showed that serum iron and zinc levels in workers" with the ALAD 1-2 genotype were higher than those with the ALAD 1-1 genotype, especially in storage-battery workers.	Iron	42-46	aminolevulinate dehydratase	Homo sapiens	134-138
22465143-5	2012	Specifically, heme iron associated with the Hp2-2/Hb complex is more redox active than other Hp type complexes and has been shown in a number of systems to lead to increased levels of oxidative stress in the form of oxidized lipids and decreased lipoprotein function.	Iron	19-23	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	44-49
22492739-6	2012	These results indicate that olfactory uptake of ferric iron by iron-deficient rats involves DMT1.	Iron	55-59	RoBo-1	Rattus norvegicus	92-96
22492739-7	2012	Western blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue.	Iron	80-84	RoBo-1	Rattus norvegicus	40-44
22492739-7	2012	Western blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue.	Iron	114-118	RoBo-1	Rattus norvegicus	40-44
22492739-8	2012	Thus the molecular mechanism of olfactory iron absorption is regulated by body iron status and involves DMT1.	Iron	42-46	RoBo-1	Rattus norvegicus	104-108
22414210-3	2012	In Arabidopsis thaliana, the ferrochelation step is catalysed by sirohydrochlorin ferrochelatase (SirB), which, unlike its counterparts in bacteria, contains an [Fe-S] cluster.	Iron	162-166	sirohydrochlorin ferrochelatase B	Arabidopsis thaliana	98-102
22465847-1	2012	A relationship between iron and fibroblast growth factor-23 (FGF23) metabolic pathways has been proposed.	Iron	23-27	fibroblast growth factor 23	Homo sapiens	32-59
22465847-1	2012	A relationship between iron and fibroblast growth factor-23 (FGF23) metabolic pathways has been proposed.	Iron	23-27	fibroblast growth factor 23	Homo sapiens	61-66
22465847-11	2012	This study provides support for the contention that iron may be involved in FGF23 metabolic pathways.	Iron	52-56	fibroblast growth factor 23	Homo sapiens	76-81
22449175-0	2012	Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression.	Iron	41-45	hepcidin antimicrobial peptide	Mus musculus	77-85
22449175-1	2012	The BMP/SMAD signalling pathway plays an important role in iron homeostasis, regulating hepcidin expression in response to body iron levels.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	88-96
22449175-1	2012	The BMP/SMAD signalling pathway plays an important role in iron homeostasis, regulating hepcidin expression in response to body iron levels.	Iron	128-132	hepcidin antimicrobial peptide	Mus musculus	88-96
22449175-2	2012	However, the role of this pathway in the reduction in hepcidin associated with increased erythropoiesis (and secondary iron loading) is unclear.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	54-62
22207682-1	2012	BACKGROUND: Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected.	Iron	12-16	hepcidin antimicrobial peptide	Mus musculus	59-67
22207682-1	2012	BACKGROUND: Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	59-67
22207322-5	2012	RESULTS: Iron infusion during the HD session increased the percentage of mononuclear cells with reactive oxygen species (ROS) production, Inter-Cellular Adhesion Molecule-1 (ICAM-1) and apoptosis.	Iron	9-13	intercellular adhesion molecule 1	Homo sapiens	138-172
22207322-5	2012	RESULTS: Iron infusion during the HD session increased the percentage of mononuclear cells with reactive oxygen species (ROS) production, Inter-Cellular Adhesion Molecule-1 (ICAM-1) and apoptosis.	Iron	9-13	intercellular adhesion molecule 1	Homo sapiens	174-180
22207322-7	2012	Culture of mononuclear cells from healthy individuals and CKD-5 patients with the different iron preparations resulted in a significant increase in ROS, ICAM-1 and apoptosis as compared with control.	Iron	92-96	intercellular adhesion molecule 1	Homo sapiens	153-159
22453918-0	2012	The iron chelators Dp44mT and DFO inhibit TGF-beta-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).	Iron	4-8	N-myc downstream regulated 1	Homo sapiens	149-154
22453918-3	2012	NDRG1 expression is markedly increased after chelator-mediated iron depletion via hypoxia-inducible factor 1alpha-dependent and independent pathways (Le, N. T. and Richardson, D. R. (2004) Blood 104, 2967-2975).	Iron	63-67	N-myc downstream regulated 1	Homo sapiens	0-5
22453918-5	2012	Considering this, the current study investigated the relationship between NDRG1 and the EMT to examine if iron chelators can inhibit the EMT via NDRG1 up-regulation.	Iron	106-110	N-myc downstream regulated 1	Homo sapiens	145-150
22383698-7	2012	Whereas hepcidin was critical for the upregulation of L-ferritin and H-ferritin in both ox-LDL-treated erythrophagocytosed macrophages and atherosclerotic plaques, the adding of iron chelators suppressed the intracellular lipid accumulation, reactive oxygen species formation, inflammatory cytokine expression, and apoptosis in erythrophagocytosed macrophages.	Iron	178-182	hepcidin antimicrobial peptide	Mus musculus	8-16
22383698-8	2012	CONCLUSIONS: Hepcidin promotes plaque destabilization partly by exaggerating inflammatory cytokine release, intracellular lipid accumulation, oxidative stress, and apoptosis in the macrophages with iron retention.	Iron	198-202	hepcidin antimicrobial peptide	Mus musculus	13-21
22510772-3	2012	In the English literature, transfusional iron overload and the use of an iron chelator in children with FAA has not yet been evaluated.	Iron	73-77	FA complementation group A	Homo sapiens	104-107
22404347-0	2012	Genetic polymorphisms in bovine transferrin receptor 2 (TFR2) and solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) genes and their association with beef iron content.	Iron	178-182	transferrin receptor 2	Bos taurus	32-54
22404347-0	2012	Genetic polymorphisms in bovine transferrin receptor 2 (TFR2) and solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) genes and their association with beef iron content.	Iron	178-182	transferrin receptor 2	Bos taurus	56-60
22404347-5	2012	Ten novel SNPs were identified in TFR2, of which one SNP tended to be associated (P &lt; 0.013) with skeletal muscle iron content.	Iron	117-121	transferrin receptor 2	Bos taurus	34-38
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	heme oxygenase 1	Rattus norvegicus	142-158
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	heme oxygenase 1	Rattus norvegicus	160-163
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	synuclein alpha	Rattus norvegicus	342-357
22585610-2	2012	Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration.	Iron	70-74	synuclein alpha	Rattus norvegicus	359-362
22585610-4	2012	Consistent with these sex-associated alterations in iron-related regulators, the expression of ASN mRNA and protein in the female hippocampus was lower than that found in male rats.	Iron	52-56	synuclein alpha	Rattus norvegicus	95-98
22399131-3	2012	Previous reports by our laboratories show that the sequence EIEYE in the plug domain is highly conserved among various bacterial species that express TbpA and plays a crucial role in iron utilization for gonococci.	Iron	183-187	transthyretin	Homo sapiens	150-154
22019713-1	2012	Transferrin receptor-1 (TfR1) is a cell membrane-associated glycoprotein responsible for incorporation of the iron bound to transferrin through an endocytotic process from the circulating blood.	Iron	110-114	transferrin	Mus musculus	124-135
22262759-1	2012	The circulating peptide hormone hepcidin maintains systemic iron homeostasis.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	32-40
22262759-3	2012	Elevated hepcidin levels decrease dietary iron absorption and promote iron sequestration in reticuloendothelial macrophages.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	9-17
22262759-3	2012	Elevated hepcidin levels decrease dietary iron absorption and promote iron sequestration in reticuloendothelial macrophages.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	9-17
22066515-9	2012	However, the phytochelatin-deficient mutant cad1-3 showed normal Fe-mediated Zn tolerance.	Iron	65-67	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	44-48
22371224-1	2012	Neutrophil gelatinase-associated lipocalin (NGAL) is a protein which participates in iron trafficking and which is involved in cancerogenesis and cancer progression.	Iron	85-89	lipocalin 2	Homo sapiens	0-42
22371224-1	2012	Neutrophil gelatinase-associated lipocalin (NGAL) is a protein which participates in iron trafficking and which is involved in cancerogenesis and cancer progression.	Iron	85-89	lipocalin 2	Homo sapiens	44-48
22309771-3	2012	We recently demonstrated that the yeast homologues of human Glrx3 and the yeast BolA-like protein Fra2 form [2Fe-2S]-bridged heterodimers that play a key role in signaling intracellular iron availability.	Iron	186-190	Bol2p	Saccharomyces cerevisiae S288C	98-102
22327295-7	2012	Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process.	Iron	111-115	transthyretin	Homo sapiens	97-101
22157760-0	2012	Iron-responsive transcription factor Aft1 interacts with kinetochore protein Iml3 and promotes pericentromeric cohesin.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	37-41
22157760-1	2012	The Saccharomyces cerevisiae iron-responsive transcription factor, Aft1, has a well established role in regulating iron homeostasis through the transcriptional induction of iron-regulon genes.	Iron	29-33	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	67-71
22157760-1	2012	The Saccharomyces cerevisiae iron-responsive transcription factor, Aft1, has a well established role in regulating iron homeostasis through the transcriptional induction of iron-regulon genes.	Iron	115-119	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	67-71
22157760-1	2012	The Saccharomyces cerevisiae iron-responsive transcription factor, Aft1, has a well established role in regulating iron homeostasis through the transcriptional induction of iron-regulon genes.	Iron	115-119	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	67-71
22068601-7	2012	Expression of the neuron-specific synaptogenesis marker, disc-large homolog 4 (PSD95), increased more rapidly than the glia-specific myelination marker, myelin basic protein, following iron treatment, suggesting a more robust response to iron therapy in IGF-I-dependent neurons than IGF-II-dependent glia.	Iron	185-189	myelin basic protein	Rattus norvegicus	153-173
22068601-7	2012	Expression of the neuron-specific synaptogenesis marker, disc-large homolog 4 (PSD95), increased more rapidly than the glia-specific myelination marker, myelin basic protein, following iron treatment, suggesting a more robust response to iron therapy in IGF-I-dependent neurons than IGF-II-dependent glia.	Iron	185-189	insulin-like growth factor 2	Rattus norvegicus	283-289
22104192-5	2012	One feature of hemoglobinopathies, observed both in humans and mice, is the fact that individuals carrying these disorders express low levels of the hormone hepcidin that plays a major role in iron homeostasis.	Iron	193-197	hepcidin antimicrobial peptide	Mus musculus	157-165
21943374-0	2012	Iron-mediated retinal degeneration in haemojuvelin-knockout mice.	Iron	0-4	hemojuvelin BMP co-receptor	Mus musculus	38-50
21943374-1	2012	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	42-46	homeostatic iron regulator	Mus musculus	147-150
21943374-1	2012	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	42-46	transferrin receptor 2	Mus musculus	221-243
21943374-1	2012	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	homeostatic iron regulator	Mus musculus	147-150
21943374-1	2012	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	258-266
21943374-1	2012	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hemojuvelin BMP co-receptor	Mus musculus	271-274
21943374-1	2012	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hemojuvelin BMP co-receptor	Mus musculus	276-288
21943374-5	2012	Hjv-/- mice at &gt;=18 months of age had increased iron accumulation in the retina with marked morphological damage compared with age-matched controls; these changes were not found in younger mice.	Iron	51-55	hemojuvelin BMP co-receptor	Mus musculus	0-3
21943374-12	2012	Taken together, these results confirm the biological importance of HJV in the regulation of iron homoeostasis in the retina and in RPE.	Iron	92-96	hemojuvelin BMP co-receptor	Mus musculus	67-70
22324696-0	2012	Irradiation-induced formation of nanocrystallites with C15 Laves phase structure in bcc iron.	Iron	88-92	placenta associated 8	Homo sapiens	55-58
22324696-3	2012	Using density functional theory and interatomic potential calculations, we demonstrate that in alpha-iron these C15 aggregates are highly stable and immobile and that they exhibit large antiferromagnetic moments.	Iron	101-105	placenta associated 8	Homo sapiens	112-115
23080185-2	2012	Antioxidation, by depleting biologically active ferrous iron, could then have a stabilizing effect, akin to hypoxia, on HIF-1alpha; the process which controls the genetic responses to hypoxia.	Iron	56-60	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	120-130
22243581-5	2012	This is mediated by ABCE1, which is a somewhat unusual member of the ATP-binding cassette family of proteins with no membrane-spanning domain but two essential iron-sulfur clusters.	Iron	160-164	ATP binding cassette subfamily E member 1	Homo sapiens	20-25
22627273-1	2012	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL, siderocalin) is a protein secreted by the kidney in the setting of acute kidney injury in an attempt to regulate and bind the release of catalytic iron from injured cells.	Iron	209-213	lipocalin 2	Homo sapiens	12-54
22627273-1	2012	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL, siderocalin) is a protein secreted by the kidney in the setting of acute kidney injury in an attempt to regulate and bind the release of catalytic iron from injured cells.	Iron	209-213	lipocalin 2	Homo sapiens	56-60
22745546-8	2012	Examination of paraffin sections of tumor tissues stained for the iron constituent of the NPs with Prussian blue revealed a strong blue reaction in the tumors of anti-VEGF-NP-treated mice, but only a weak reaction in mice injected with NPs.	Iron	66-70	vascular endothelial growth factor A	Mus musculus	167-171
22973307-2	2012	Bacteria such as P. aeruginosa secrete siderophores (iron-chelating molecules) and the host limits bacterial growth by producing neutrophil-gelatinase-associated lipocalin (NGAL) that specifically scavenges bacterial siderophores, therefore preventing bacteria from establishing infection.	Iron	53-57	lipocalin 2	Homo sapiens	173-177
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	135-139
22234997-7	2012	We conclude that a local symplastic Fe gradient in lateral roots upregulates AUX1 to accumulate auxin in lateral root apices as a prerequisite for lateral root elongation.	Iron	36-38	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	77-81
23028567-1	2012	Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	0-8
23028567-1	2012	Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	0-8
23028567-1	2012	Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	0-8
23028567-2	2012	Hepcidin is synthesized mainly in the liver, where hepcidin is regulated by iron loading, inflammation and hypoxia.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	0-8
23028567-2	2012	Hepcidin is synthesized mainly in the liver, where hepcidin is regulated by iron loading, inflammation and hypoxia.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	51-59
23028567-5	2012	Studies have shown that hepcidin expression by macrophages increases following bacterial infection, and that hepcidin decreases iron release from macrophages in an autocrine and/or paracrine manner.	Iron	128-132	hepcidin antimicrobial peptide	Mus musculus	109-117
22984573-0	2012	Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway.	Iron	40-44	basic helix-loop-helix protein 100	Arabidopsis thaliana	12-19
22984573-4	2012	Only the basic helix-loop-helix (bHLH) transcription factor FIT has been shown to control the expression of the root iron uptake machinery genes FRO2 and IRT1.	Iron	117-121	iron-regulated transporter 1	Arabidopsis thaliana	154-158
22984573-5	2012	Here, we characterize the biological role of two other iron-regulated transcription factors, bHLH100 and bHLH101, in iron homeostasis.	Iron	55-59	basic helix-loop-helix protein 100	Arabidopsis thaliana	93-100
22984573-5	2012	Here, we characterize the biological role of two other iron-regulated transcription factors, bHLH100 and bHLH101, in iron homeostasis.	Iron	117-121	basic helix-loop-helix protein 100	Arabidopsis thaliana	93-100
22984573-8	2012	bHLH100 and bHLH101 play a crucial role in iron-deficiency responses, as attested by their severe growth defects and iron homeostasis related phenotypes on low-iron media.	Iron	43-47	basic helix-loop-helix protein 100	Arabidopsis thaliana	0-7
22984573-8	2012	bHLH100 and bHLH101 play a crucial role in iron-deficiency responses, as attested by their severe growth defects and iron homeostasis related phenotypes on low-iron media.	Iron	117-121	basic helix-loop-helix protein 100	Arabidopsis thaliana	0-7
22984573-9	2012	To gain further insight into the biological role of bHLH100 and bHLH101, we performed microarray analysis using the corresponding double mutant and showed that bHLH100 and bHLH101 likely regulate genes involved in the distribution of iron within the plant.	Iron	234-238	basic helix-loop-helix protein 100	Arabidopsis thaliana	52-59
22984573-9	2012	To gain further insight into the biological role of bHLH100 and bHLH101, we performed microarray analysis using the corresponding double mutant and showed that bHLH100 and bHLH101 likely regulate genes involved in the distribution of iron within the plant.	Iron	234-238	basic helix-loop-helix protein 100	Arabidopsis thaliana	160-167
22984573-10	2012	Altogether, this work establishes bHLH100 and bHLH101 as key regulators of iron-deficiency responses independent of the master regulator FIT and sheds light on new regulatory networks important for proper growth and development under low iron conditions.	Iron	75-79	basic helix-loop-helix protein 100	Arabidopsis thaliana	34-41
22928018-1	2012	Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators.	Iron	51-55	lipocalin 2	Homo sapiens	18-29
22928018-1	2012	Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators.	Iron	51-55	lipocalin 2	Homo sapiens	31-35
22928018-1	2012	Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators.	Iron	51-55	lipocalin 2	Homo sapiens	39-43
22745741-2	2012	Here we investigate how imbalanced systemic iron homeostasis in a murine disease model of hereditary hemochromatosis (Hfe(-/-) mice) affects the inflammatory responses of the lung.	Iron	44-48	homeostatic iron regulator	Mus musculus	118-121
22761678-6	2012	SNP rs10904850 in the CUBN gene on 10p13 was associated with serum iron in African Americans (P = 1.0 x 10(-5)).	Iron	67-71	cubilin	Homo sapiens	22-26
22253756-3	2012	Mitoferrin 1 and mitoferrin 2, two homologues proteins belonging to the mitochondrial solute carrier family, are required for iron delivery into mitochondria.	Iron	126-130	Mitoferrin	Caenorhabditis elegans	17-27
22138393-1	2011	HIF-1alpha plays a key role in iron uptake and transport in the liver, whose activity is tightly linked to the repression of hepcidin (Hamp).	Iron	31-35	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
22333152-5	2011	And the changes of these indices were tested after the treatment of iron overload UCB with antioxidants (NAC and GSH).	Iron	68-72	X-linked Kx blood group	Homo sapiens	105-108
22174555-1	2011	A liver-produced hormone, hepcidin, appears to be the key player in iron metabolism.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	26-34
21274654-8	2011	Since alterations in iron levels in the brain are causally linked to degenerative conditions such as Alzheimer"s disease, an improved understanding of the regulation of iron transport protein expression such as FPN1, DMT1, and CP could lead to novel strategies for treatments.	Iron	169-173	RoBo-1	Rattus norvegicus	217-221
21955150-6	2011	We developed LNA-aptamer (anti-nucleolin and EpCAM) complexes which were loaded in iron-saturated bovine lactofeerin (Fe-blf)-coated dopamine modified surface of superparamagnetic iron oxide (Fe(3)O(4)) nanoparticles (SPIONs).	Iron	83-87	nucleolin	Bos taurus	31-40
21955150-6	2011	We developed LNA-aptamer (anti-nucleolin and EpCAM) complexes which were loaded in iron-saturated bovine lactofeerin (Fe-blf)-coated dopamine modified surface of superparamagnetic iron oxide (Fe(3)O(4)) nanoparticles (SPIONs).	Iron	83-87	epithelial cell adhesion molecule	Bos taurus	45-50
22045566-0	2011	Minihepcidins are rationally designed  small peptides that mimic hepcidin activity  in mice and may be useful for the treatment  of iron overload.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	4-12
22045566-3	2011	Iron overload in hereditary hemochromatosis and beta-thalassemia intermedia is caused by hepcidin deficiency.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	89-97
22045566-4	2011	Although transgenic hepcidin replacement in mouse models of these diseases prevents iron overload or decreases its potential toxicity, natural hepcidin is prohibitively expensive for human application and has unfavorable pharmacologic properties.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	20-28
22058337-9	2011	In all cases of iron overload, the expression of FLVCR and PCFT was upregulated and that of BCRP was downregulated.	Iron	16-20	solute carrier family 46, member 1	Mus musculus	59-63
21715309-0	2011	Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.	Iron	86-90	Rho guanine nucleotide exchange factor (GEF) 3	Danio rerio	46-53
21715309-4	2011	Here, we report on the unexpected role of ARHGEF3 in regulation of iron uptake and erythroid cell maturation.	Iron	67-71	Rho guanine nucleotide exchange factor (GEF) 3	Danio rerio	42-49
21715309-6	2011	This was rescued by intracellular supplementation of iron, showing that arhgef3-depleted erythroid cells are fully capable of hemoglobinization.	Iron	53-57	Rho guanine nucleotide exchange factor (GEF) 3	Danio rerio	72-79
21715309-7	2011	Disruption of the arhgef3 target, RhoA, also produced severe anemia, which was, again, corrected by iron injection.	Iron	100-104	Rho guanine nucleotide exchange factor (GEF) 3	Danio rerio	18-25
21959970-3	2011	Bulk bone collagen isotopic analysis of 11 skeletons of Iron Age and Roman date gave a typical C(3) terrestrial signal (average delta(13) C = -19.8%, delta(15) N = 9.3%), but also revealed one (SK12671) with a diet which included a substantial C(4) component (delta(13) C = -15.2%, delta(15) N = 11.2%).	Iron	56-60	complement C3	Homo sapiens	95-99
22123561-1	2011	Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein of 25 kDa belonging to the superfamily of lipocalins, which counts low molecular mass proteins having the capacity to fix the iron.	Iron	194-198	lipocalin 2	Homo sapiens	0-42
22123561-1	2011	Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein of 25 kDa belonging to the superfamily of lipocalins, which counts low molecular mass proteins having the capacity to fix the iron.	Iron	194-198	lipocalin 2	Homo sapiens	44-48
21745449-0	2011	Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	19-27
21745449-1	2011	BACKGROUND &amp; AIMS: HFE and transferrin receptor 2 (TFR2) are each necessary for the normal relationship between body iron status and liver hepcidin expression.	Iron	121-125	homeostatic iron regulator	Mus musculus	23-26
21745449-1	2011	BACKGROUND &amp; AIMS: HFE and transferrin receptor 2 (TFR2) are each necessary for the normal relationship between body iron status and liver hepcidin expression.	Iron	121-125	transferrin receptor 2	Mus musculus	31-53
21745449-1	2011	BACKGROUND &amp; AIMS: HFE and transferrin receptor 2 (TFR2) are each necessary for the normal relationship between body iron status and liver hepcidin expression.	Iron	121-125	transferrin receptor 2	Mus musculus	55-59
21745449-1	2011	BACKGROUND &amp; AIMS: HFE and transferrin receptor 2 (TFR2) are each necessary for the normal relationship between body iron status and liver hepcidin expression.	Iron	121-125	hepcidin antimicrobial peptide	Mus musculus	143-151
21745449-3	2011	We examined the effect of dietary iron on regulation of hepcidin expression via the Bmp6/Smad1,5,8 pathway using mice with targeted disruption of Tfr2, Hfe, or both genes.	Iron	34-38	hepcidin antimicrobial peptide	Mus musculus	56-64
21745449-9	2011	Dietary iron loading increased hepcidin and Id1 expression in each of the HH models.	Iron	8-12	hepcidin antimicrobial peptide	Mus musculus	31-39
21745449-9	2011	Dietary iron loading increased hepcidin and Id1 expression in each of the HH models.	Iron	8-12	inhibitor of DNA binding 1, HLH protein	Mus musculus	44-47
21745449-11	2011	CONCLUSIONS: These observations show that Tfr2 and Hfe are each required for normal signaling of iron status to hepcidin via the Bmp6/Smad1,5,8 pathway.	Iron	97-101	transferrin receptor 2	Mus musculus	42-46
21745449-11	2011	CONCLUSIONS: These observations show that Tfr2 and Hfe are each required for normal signaling of iron status to hepcidin via the Bmp6/Smad1,5,8 pathway.	Iron	97-101	homeostatic iron regulator	Mus musculus	51-54
21745449-11	2011	CONCLUSIONS: These observations show that Tfr2 and Hfe are each required for normal signaling of iron status to hepcidin via the Bmp6/Smad1,5,8 pathway.	Iron	97-101	hepcidin antimicrobial peptide	Mus musculus	112-120
21745449-12	2011	Mice with combined loss of Hfe and Tfr2 up-regulate hepcidin in response to dietary iron loading without increases in liver Bmp6 messenger RNA or steady-state P-Smad1,5,8 levels.	Iron	84-88	homeostatic iron regulator	Mus musculus	27-30
21745449-12	2011	Mice with combined loss of Hfe and Tfr2 up-regulate hepcidin in response to dietary iron loading without increases in liver Bmp6 messenger RNA or steady-state P-Smad1,5,8 levels.	Iron	84-88	transferrin receptor 2	Mus musculus	35-39
21745449-12	2011	Mice with combined loss of Hfe and Tfr2 up-regulate hepcidin in response to dietary iron loading without increases in liver Bmp6 messenger RNA or steady-state P-Smad1,5,8 levels.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	52-60
21748766-0	2011	Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.	Iron	67-71	hemojuvelin BMP co-receptor	Mus musculus	32-36
21748766-1	2011	UNLABELLED: Mutations of the HFE2 gene are linked to juvenile hemochromatosis, a severe hereditary iron overload disease caused by chronic hyperabsorption of dietary iron.	Iron	99-103	hemojuvelin BMP co-receptor	Mus musculus	29-33
21748766-6	2011	The hepatic ablation of Hjv resulted in iron overload, quantitatively comparable to that observed in ubiquitous Hjv-/- mice.	Iron	40-44	hemojuvelin BMP co-receptor	Mus musculus	24-27
21748766-7	2011	Serum iron and ferritin levels, transferrin saturation, and liver iron content were significantly (P &lt; 0.001) elevated in liver-specific Hjv-/- mice.	Iron	6-10	hemojuvelin BMP co-receptor	Mus musculus	140-143
21748766-7	2011	Serum iron and ferritin levels, transferrin saturation, and liver iron content were significantly (P &lt; 0.001) elevated in liver-specific Hjv-/- mice.	Iron	66-70	hemojuvelin BMP co-receptor	Mus musculus	140-143
21748766-11	2011	CONCLUSION: The hemochromatotic phenotype of liver-specific Hjv-/- mice suggests that hepatic Hjv is necessary and sufficient to regulate hepcidin expression and control systemic iron homeostasis.	Iron	179-183	hemojuvelin BMP co-receptor	Mus musculus	94-97
21880793-12	2011	CONCLUSIONS: Low serum iron is associated with elevated FGF23 in ADHR.	Iron	23-27	fibroblast growth factor 23	Homo sapiens	56-61
21880793-13	2011	However, in controls, low serum iron was also associated with elevated C-terminal FGF23, but not intact FGF23, suggesting cleavage maintains homeostasis despite increased FGF23 expression.	Iron	32-36	fibroblast growth factor 23	Homo sapiens	82-87
22019886-6	2011	Expression of human IgA1 or treatment of wild-type mice with the TfR1 ligands pIgA1 or iron-loaded transferrin (Fe-Tf) accelerated recovery from acute anemia.	Iron	87-91	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
22019886-6	2011	Expression of human IgA1 or treatment of wild-type mice with the TfR1 ligands pIgA1 or iron-loaded transferrin (Fe-Tf) accelerated recovery from acute anemia.	Iron	87-91	transferrin	Mus musculus	99-110
21852233-10	2011	Furthermore, like GADD45alpha, NF-YA was up-regulated after iron chelation and down-regulated by iron supplementation.	Iron	60-64	nuclear transcription factor Y subunit alpha	Homo sapiens	31-36
21852233-10	2011	Furthermore, like GADD45alpha, NF-YA was up-regulated after iron chelation and down-regulated by iron supplementation.	Iron	97-101	nuclear transcription factor Y subunit alpha	Homo sapiens	31-36
21841161-0	2011	Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	16-24
21841161-2	2011	Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin.	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	0-8
21841161-2	2011	Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	0-8
21841161-3	2011	A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iron overload disorders, collectively termed hereditary hemochromatosis.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	25-33
21841161-4	2011	Conversely, chronic inflammatory conditions and neoplastic diseases can induce high hepcidin levels, leading to impaired mobilization of iron stores and the anemia of chronic disease.	Iron	137-141	hepcidin antimicrobial peptide	Mus musculus	84-92
21841161-6	2011	We report that liver-specific deletion of either Alk2 or Alk3 causes iron overload in mice.	Iron	69-73	activin A receptor, type 1	Mus musculus	49-53
21841161-6	2011	We report that liver-specific deletion of either Alk2 or Alk3 causes iron overload in mice.	Iron	69-73	bone morphogenetic protein receptor, type 1A	Mus musculus	57-61
21841161-7	2011	The iron overload phenotype was more marked in Alk3- than in Alk2-deficient mice, and Alk3 deficiency was associated with a nearly complete ablation of basal BMP signaling and hepcidin expression.	Iron	4-8	bone morphogenetic protein receptor, type 1A	Mus musculus	47-51
21841161-7	2011	The iron overload phenotype was more marked in Alk3- than in Alk2-deficient mice, and Alk3 deficiency was associated with a nearly complete ablation of basal BMP signaling and hepcidin expression.	Iron	4-8	activin A receptor, type 1	Mus musculus	61-65
21841161-8	2011	Both Alk2 and Alk3 were required for induction of hepcidin gene expression by BMP2 in cultured hepatocytes or by iron challenge in vivo.	Iron	113-117	activin A receptor, type 1	Mus musculus	5-9
21841161-8	2011	Both Alk2 and Alk3 were required for induction of hepcidin gene expression by BMP2 in cultured hepatocytes or by iron challenge in vivo.	Iron	113-117	bone morphogenetic protein receptor, type 1A	Mus musculus	14-18
21841161-8	2011	Both Alk2 and Alk3 were required for induction of hepcidin gene expression by BMP2 in cultured hepatocytes or by iron challenge in vivo.	Iron	113-117	hepcidin antimicrobial peptide	Mus musculus	50-58
21841161-9	2011	These observations demonstrate that one type I BMP receptor, Alk3, is critically responsible for basal hepcidin expression, whereas 2 type I BMP receptors, Alk2 and Alk3, are required for regulation of hepcidin gene expression in response to iron and BMP signaling.	Iron	242-246	hepcidin antimicrobial peptide	Mus musculus	202-210
21936912-5	2011	In both patients, sequencing of the FTL 5" region showed previously described mutations within the iron responsive element (FTL c.33 C &gt; A and FTL c.32G &gt; C).	Iron	99-103	ferritin light chain	Homo sapiens	36-39
21936912-5	2011	In both patients, sequencing of the FTL 5" region showed previously described mutations within the iron responsive element (FTL c.33 C &gt; A and FTL c.32G &gt; C).	Iron	99-103	ferritin light chain	Homo sapiens	124-127
21936912-5	2011	In both patients, sequencing of the FTL 5" region showed previously described mutations within the iron responsive element (FTL c.33 C &gt; A and FTL c.32G &gt; C).	Iron	99-103	ferritin light chain	Homo sapiens	124-127
21936923-1	2011	BACKGROUND: Hemojuvelin (HJV) is one of essential components for expression of hepcidin, a hormone which regulates iron transport.	Iron	115-119	hemojuvelin BMP co-receptor	Mus musculus	12-23
21936923-1	2011	BACKGROUND: Hemojuvelin (HJV) is one of essential components for expression of hepcidin, a hormone which regulates iron transport.	Iron	115-119	hemojuvelin BMP co-receptor	Mus musculus	25-28
21936923-1	2011	BACKGROUND: Hemojuvelin (HJV) is one of essential components for expression of hepcidin, a hormone which regulates iron transport.	Iron	115-119	hepcidin antimicrobial peptide	Mus musculus	79-87
21593278-0	2011	Modulation of hepatitis C virus replication by iron and hepcidin in Huh7 hepatocytes.	Iron	47-51	MIR7-3 host gene	Homo sapiens	68-72
21812646-13	2011	Serum iron was inversely proportional to the levels of ferritin and transferrin and total iron-binding capacity.	Iron	6-10	transferrin	Mus musculus	68-79
21755988-9	2011	This supports a model in which Hsp70 binding to apo-nNOS stabilizes an open state of the heme/substrate binding cleft to facilitate thioredoxin access to the active site cysteine that coordinates with heme iron, permitting heme binding and dimerization to the active enzyme.	Iron	206-210	heat shock protein family A (Hsp70) member 4	Homo sapiens	31-36
21652729-2	2011	We have previously demonstrated that ferric ions bind to gastrins, that the gastrin-ferric ion complex interacts with the iron transport protein transferrin in vitro, and that circulating gastrin concentrations positively correlate with transferrin saturation in vivo.	Iron	122-126	transferrin	Mus musculus	145-156
21652729-7	2011	The expression of the mRNA encoding the iron-regulatory peptide hepcidin, Hamp, was down-regulated in both Cck2r(-/-) and Gas(-/-) mice on a low-iron diet, but, interestingly, the reduction was greater in Cck2r(-/-) mice and smaller in Gas(-/-) mice than in the corresponding wild-type strains.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	64-72
21652729-7	2011	The expression of the mRNA encoding the iron-regulatory peptide hepcidin, Hamp, was down-regulated in both Cck2r(-/-) and Gas(-/-) mice on a low-iron diet, but, interestingly, the reduction was greater in Cck2r(-/-) mice and smaller in Gas(-/-) mice than in the corresponding wild-type strains.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	74-78
21652729-7	2011	The expression of the mRNA encoding the iron-regulatory peptide hepcidin, Hamp, was down-regulated in both Cck2r(-/-) and Gas(-/-) mice on a low-iron diet, but, interestingly, the reduction was greater in Cck2r(-/-) mice and smaller in Gas(-/-) mice than in the corresponding wild-type strains.	Iron	40-44	cholecystokinin B receptor	Mus musculus	107-112
21652729-7	2011	The expression of the mRNA encoding the iron-regulatory peptide hepcidin, Hamp, was down-regulated in both Cck2r(-/-) and Gas(-/-) mice on a low-iron diet, but, interestingly, the reduction was greater in Cck2r(-/-) mice and smaller in Gas(-/-) mice than in the corresponding wild-type strains.	Iron	40-44	cholecystokinin B receptor	Mus musculus	205-210
21652729-7	2011	The expression of the mRNA encoding the iron-regulatory peptide hepcidin, Hamp, was down-regulated in both Cck2r(-/-) and Gas(-/-) mice on a low-iron diet, but, interestingly, the reduction was greater in Cck2r(-/-) mice and smaller in Gas(-/-) mice than in the corresponding wild-type strains.	Iron	145-149	hepcidin antimicrobial peptide	Mus musculus	64-72
21652729-7	2011	The expression of the mRNA encoding the iron-regulatory peptide hepcidin, Hamp, was down-regulated in both Cck2r(-/-) and Gas(-/-) mice on a low-iron diet, but, interestingly, the reduction was greater in Cck2r(-/-) mice and smaller in Gas(-/-) mice than in the corresponding wild-type strains.	Iron	145-149	hepcidin antimicrobial peptide	Mus musculus	74-78
21907119-1	2011	PURPOSE: Hereditary hyperferritinemia cataract syndrome (HHCS), an autosomal-dominant disorder characterized by hyperferritinemia and bilateral cataracts, is caused by mutations in the iron-responsive element of the ferritin light chain (FTL) gene.	Iron	185-189	ferritin light chain	Homo sapiens	216-236
21907119-1	2011	PURPOSE: Hereditary hyperferritinemia cataract syndrome (HHCS), an autosomal-dominant disorder characterized by hyperferritinemia and bilateral cataracts, is caused by mutations in the iron-responsive element of the ferritin light chain (FTL) gene.	Iron	185-189	ferritin light chain	Homo sapiens	238-241
21907119-8	2011	Genetic analysis revealed mutation G32A in Pedigree 1 and mutation G32T in Pedigree 2, both heterozygous and located in the iron-responsive element of the ferritin light chain mRNA.	Iron	124-128	ferritin light chain	Homo sapiens	155-175
21590471-4	2011	In this work, we investigated the mechanism of the reduction of the SOR iron active site using the NADPH:flavodoxin oxidoreductase from Escherichia coli, which was previously shown to efficiently transfer electrons to the Desulfoarculus baarsii SOR.	Iron	72-76	oxidoreductase	Escherichia coli	116-130
22303580-6	2011	Iron concentration of tap water from one of the locations was higher than the standard limit.	Iron	0-4	nuclear RNA export factor 1	Homo sapiens	22-25
21165730-4	2011	Increased astrocytosis, revealed by densitometry of GFAP-immunoreactive astrocytes, was found in aged (24 months) iron-treated rats in the substantia nigra and striatum and in the hippocampus of adult (3 months) iron-treated rats when compared to age-matching controls.	Iron	114-118	glial fibrillary acidic protein	Rattus norvegicus	52-56
20976594-10	2011	RESULTS: There was a significant increase in hepatic iron concentration and bone iron content in HFE (-/-) mice.	Iron	53-57	homeostatic iron regulator	Mus musculus	97-100
20976594-10	2011	RESULTS: There was a significant increase in hepatic iron concentration and bone iron content in HFE (-/-) mice.	Iron	81-85	homeostatic iron regulator	Mus musculus	97-100
21742768-6	2011	Moreover, Ni accumulation under Fe-deficient conditions was markedly lower in AtIRT1-defective mutants than in the wild-type, Col-0.	Iron	32-34	iron-regulated transporter 1	Arabidopsis thaliana	78-84
21710629-0	2011	Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis.	Iron	64-68	Meis homeobox 1	Homo sapiens	34-39
21710629-4	2011	Additionally, human cells cultured under iron-deficient conditions show reduced MEIS1 expression.	Iron	41-45	Meis homeobox 1	Homo sapiens	80-85
21710629-5	2011	Our data establish a link between the RLS MEIS1 gene and iron metabolism.	Iron	57-61	Meis homeobox 1	Homo sapiens	42-47
21549690-3	2011	RESULTS: Fe/As promoted the production of lipid peroxidation as reflected by the formation of malondialdehyde and H(2)O(2) along with reduced PUFA levels and elevated glutathione disulfide/total glutathione ratio, a reliable index of cellular redox status.	Iron	9-11	pumilio RNA binding family member 3	Homo sapiens	142-146
21922821-7	2011	Having biological, chemical advantages and high efficiency, the novel SRB-Cu/Fe system should have the broad application prospects in industrial wastewater.	Iron	77-79	chaperonin containing TCP1 subunit 4	Homo sapiens	70-73
21566147-2	2011	IRP1 is a bifunctional protein that mostly exists in a non-IRE-binding, [4Fe-4S] cluster aconitase form, whereas IRP2, which does not assemble an Fe-S cluster, spontaneously binds IREs.	Iron	146-150	aconitase 1	Mus musculus	0-4
21566147-3	2011	Although both IRPs fulfill a trans-regulatory function, only mice lacking IRP2 misregulate iron metabolism.	Iron	91-95	iron responsive element binding protein 2	Mus musculus	74-78
21566147-5	2011	IRP2 has also been reported to sense NO, but the intrinsic function of IRP1 and IRP2 in NO-mediated regulation of cellular iron metabolism is controversial.	Iron	123-127	aconitase 1	Mus musculus	71-75
21566147-5	2011	IRP2 has also been reported to sense NO, but the intrinsic function of IRP1 and IRP2 in NO-mediated regulation of cellular iron metabolism is controversial.	Iron	123-127	iron responsive element binding protein 2	Mus musculus	80-84
21566147-7	2011	The powerful action of NO on IRP1 also remedies the defects of iron storage found in IRP2-null bone marrow macrophages by efficiently reducing Ft overexpression.	Iron	63-67	aconitase 1	Mus musculus	29-33
21566147-7	2011	The powerful action of NO on IRP1 also remedies the defects of iron storage found in IRP2-null bone marrow macrophages by efficiently reducing Ft overexpression.	Iron	63-67	iron responsive element binding protein 2	Mus musculus	85-89
21566147-8	2011	We also found that NO-dependent IRP1 activation, resulting in increased iron uptake and reduced iron sequestration and export, maintains enough intracellular iron to fuel the Fe-S cluster biosynthetic pathway for efficient restoration of the citric acid cycle aconitase in mitochondria.	Iron	72-76	aconitase 1	Mus musculus	32-36
21566147-8	2011	We also found that NO-dependent IRP1 activation, resulting in increased iron uptake and reduced iron sequestration and export, maintains enough intracellular iron to fuel the Fe-S cluster biosynthetic pathway for efficient restoration of the citric acid cycle aconitase in mitochondria.	Iron	96-100	aconitase 1	Mus musculus	32-36
21566147-8	2011	We also found that NO-dependent IRP1 activation, resulting in increased iron uptake and reduced iron sequestration and export, maintains enough intracellular iron to fuel the Fe-S cluster biosynthetic pathway for efficient restoration of the citric acid cycle aconitase in mitochondria.	Iron	96-100	aconitase 1	Mus musculus	32-36
21566147-8	2011	We also found that NO-dependent IRP1 activation, resulting in increased iron uptake and reduced iron sequestration and export, maintains enough intracellular iron to fuel the Fe-S cluster biosynthetic pathway for efficient restoration of the citric acid cycle aconitase in mitochondria.	Iron	175-179	aconitase 1	Mus musculus	32-36
21566147-9	2011	Thus, IRP1 is the dominant sensor and transducer of NO for posttranscriptional regulation of iron metabolism and participates in Fe-S cluster repair after exposure to NO.	Iron	93-97	aconitase 1	Mus musculus	6-10
21566147-9	2011	Thus, IRP1 is the dominant sensor and transducer of NO for posttranscriptional regulation of iron metabolism and participates in Fe-S cluster repair after exposure to NO.	Iron	129-133	aconitase 1	Mus musculus	6-10
21554322-5	2011	However, there are more granulocytes, NK and NKT cells, and less CD4(+) T cells in the spinal cord infiltrates of SCH + CI-immunized animals.	Iron	120-122	Cd4 molecule	Rattus norvegicus	65-68
21593354-7	2011	Placental FLVCR1 expression was positively associated with placental iron concentration at delivery (n = 61; R(2) = 0.064; P &lt; 0.05).	Iron	69-73	FLVCR heme transporter 1	Homo sapiens	10-16
21593354-9	2011	Both FLVCR1 and BCRP are highly expressed in human placental tissue, but only FLVCR1 was significantly inversely associated with maternal iron status and placental iron concentration.	Iron	138-142	FLVCR heme transporter 1	Homo sapiens	78-84
21593354-9	2011	Both FLVCR1 and BCRP are highly expressed in human placental tissue, but only FLVCR1 was significantly inversely associated with maternal iron status and placental iron concentration.	Iron	164-168	FLVCR heme transporter 1	Homo sapiens	78-84
21593354-10	2011	Further analysis is needed to explore potential functional roles of FLVCR1 in human placental iron transport.	Iron	94-98	FLVCR heme transporter 1	Homo sapiens	68-74
21556420-1	2011	Iron(II) complexes of Z- and E-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine (Z-2 and E-2, respectively) exhibited visible light photoisomerization from Z-2 to E-2, both in solution and in solid phases.	Iron	0-4	cystatin 12, pseudogene	Homo sapiens	29-32
21556420-1	2011	Iron(II) complexes of Z- and E-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine (Z-2 and E-2, respectively) exhibited visible light photoisomerization from Z-2 to E-2, both in solution and in solid phases.	Iron	0-4	cystatin 12, pseudogene	Homo sapiens	81-84
21556420-1	2011	Iron(II) complexes of Z- and E-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine (Z-2 and E-2, respectively) exhibited visible light photoisomerization from Z-2 to E-2, both in solution and in solid phases.	Iron	0-4	cystatin 12, pseudogene	Homo sapiens	81-84
21346155-1	2011	Iron homeostasis-related genes (e.g., Dmt1 and Dcytb) are upregulated by hypoxia-inducible factor 2alpha (HIF2alpha) during iron deficiency in the mammalian intestine.	Iron	0-4	cytochrome b reductase 1	Homo sapiens	47-52
21346155-14	2011	In conclusion, the Atp7a gene is upregulated by direct interaction with HIF2alpha, demonstrating coordinate regulation with genes related to intestinal iron homeostasis.	Iron	152-156	endothelial PAS domain protein 1	Rattus norvegicus	72-81
21303570-1	2011	Hepcidin, the Fe-regulatory peptide, has been shown to inhibit Fe absorption and reticuloendothelial Fe recycling.	Iron	14-16	hepcidin antimicrobial peptide	Mus musculus	0-8
21303570-1	2011	Hepcidin, the Fe-regulatory peptide, has been shown to inhibit Fe absorption and reticuloendothelial Fe recycling.	Iron	63-65	hepcidin antimicrobial peptide	Mus musculus	0-8
21286947-2	2011	To date, mutations in the following genes have been associated with neurodegeneration with brain iron accumulation (NBIA) phenotypes: PANK2, PLA2G6, FA2H, ATP13A2, C2orf37, CP, and FTL.	Iron	97-101	ferritin light chain	Homo sapiens	181-184
21563758-7	2011	The dominant dust Pb species determined using X-ray Absorption Spectroscopy were as follows: Pb carbonate, Pb hydroxyl carbonate, Pb sulfate, Pb chromate, Pb oxide, Pb citrate, Pb metal, Pb adsorbed to Fe- and Al-oxyhydroxides, and Pb adsorbed to humate.	Iron	202-204	translocator protein	Homo sapiens	18-20
21426424-2	2011	In the model plant Arabidopsis thaliana, the ferric-chelate reductase FRO2 and the ferrous iron transporter IRT1 control iron entry from the soil into the root epidermis.	Iron	91-95	iron-regulated transporter 1	Arabidopsis thaliana	108-112
21426424-3	2011	To maintain iron homeostasis, the expression of FRO2 and IRT1 is tightly controlled by iron deficiency at the transcriptional level.	Iron	12-16	iron-regulated transporter 1	Arabidopsis thaliana	57-61
21426424-4	2011	The basic helix-loop-helix (bHLH) transcription factor FIT represents the most upstream actor known in the iron-deficiency signaling pathway, and directly regulates the expression of the root iron uptake machinery genes FRO2 and IRT1.	Iron	107-111	iron-regulated transporter 1	Arabidopsis thaliana	229-233
21426424-8	2011	This post-transcriptional regulation of FIT is perfectly synchronized with the accumulation of endogenous FIT and IRT1 proteins, and therefore is part of the early responses to low iron.	Iron	181-185	iron-regulated transporter 1	Arabidopsis thaliana	114-118
21426424-10	2011	In addition, we showed that FIT post-translational regulation by iron is required for FRO2 and IRT1 gene expression.	Iron	65-69	iron-regulated transporter 1	Arabidopsis thaliana	95-99
21624143-2	2011	Previous studies with a SO2426-deficient MR-1 strain suggested a putative functional role for SO2426 in the regulation of iron acquisition genes, in particular, the siderophore (hydroxamate) biosynthesis operon so3030-3031-3032.	Iron	122-126	response regulator transcription factor	Shewanella oneidensis MR-1	24-30
21624143-2	2011	Previous studies with a SO2426-deficient MR-1 strain suggested a putative functional role for SO2426 in the regulation of iron acquisition genes, in particular, the siderophore (hydroxamate) biosynthesis operon so3030-3031-3032.	Iron	122-126	response regulator transcription factor	Shewanella oneidensis MR-1	94-100
21624143-10	2011	Finally, the so2426 deletion mutant was unable to synthesize siderophores at wild-type rates upon exposure to the iron chelator 2,2"-dipyridyl.	Iron	114-118	response regulator transcription factor	Shewanella oneidensis MR-1	13-19
21624143-11	2011	CONCLUSIONS: Collectively, these data support the functional characterization of SO2426 as a positive regulator of siderophore-mediated iron acquisition and provide the first insight into a coordinate program of multiple regulatory schemes controlling iron homeostasis in S. oneidensis MR-1.	Iron	136-140	response regulator transcription factor	Shewanella oneidensis MR-1	81-87
21624143-11	2011	CONCLUSIONS: Collectively, these data support the functional characterization of SO2426 as a positive regulator of siderophore-mediated iron acquisition and provide the first insight into a coordinate program of multiple regulatory schemes controlling iron homeostasis in S. oneidensis MR-1.	Iron	252-256	response regulator transcription factor	Shewanella oneidensis MR-1	81-87
21513309-5	2011	CYP2A6-catalyzed (S)-(-)-nicotine 5"-hydroxylation consists of two reaction steps, that is, the hydrogen transfer from the 5"-position of (S)-(-)-nicotine to the oxygen of Cpd I (the H-transfer step), followed by the recombination of the (S)-(-)-nicotine moiety with the iron-bound hydroxyl group to generate the 5"-hydroxynicotine product (the O-rebound step).	Iron	271-275	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
21776189-1	2011	Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, catalyzes the insertion of ferrous iron into protoporphyrin IX to give heme.	Iron	97-109	ferrochelatase	Homo sapiens	0-14
20369315-7	2011	When adults were compared, iron-treated animals presented significantly higher Par-4 and caspase-3 immunoreactivities in CA1, CA3 and cortex.	Iron	27-31	pro-apoptotic WT1 regulator	Rattus norvegicus	79-84
20369315-7	2011	When adults were compared, iron-treated animals presented significantly higher Par-4 and caspase-3 immunoreactivities in CA1, CA3 and cortex.	Iron	27-31	carbonic anhydrase 3	Rattus norvegicus	126-129
21411332-3	2011	In this report we have investigated a small family of five nodulin-like genes that show protein sequence similarity to AtVIT1 and likely have a function in regulation of Fe homeostasis.	Iron	170-172	vacuolar iron transporter 1	Arabidopsis thaliana	119-125
21355094-1	2011	The hereditary hemochromatosis protein HFE promotes the expression of hepcidin, a circulating hormone produced by the liver that inhibits dietary iron absorption and macrophage iron release.	Iron	146-150	homeostatic iron regulator	Mus musculus	39-42
21355094-1	2011	The hereditary hemochromatosis protein HFE promotes the expression of hepcidin, a circulating hormone produced by the liver that inhibits dietary iron absorption and macrophage iron release.	Iron	146-150	hepcidin antimicrobial peptide	Mus musculus	70-78
21355094-1	2011	The hereditary hemochromatosis protein HFE promotes the expression of hepcidin, a circulating hormone produced by the liver that inhibits dietary iron absorption and macrophage iron release.	Iron	177-181	homeostatic iron regulator	Mus musculus	39-42
21355094-1	2011	The hereditary hemochromatosis protein HFE promotes the expression of hepcidin, a circulating hormone produced by the liver that inhibits dietary iron absorption and macrophage iron release.	Iron	177-181	hepcidin antimicrobial peptide	Mus musculus	70-78
21355094-4	2011	In the present study, we used genetic approaches in mice to examine the relationship between Hfe and Tmprss6 in the regulation of systemic iron homeostasis.	Iron	139-143	homeostatic iron regulator	Mus musculus	93-96
21199652-3	2011	We studied human polarized intestinal (Caco-2/TC7) cells and mouse duodenal segments, ex vivo, to investigate the molecular mechanisms by which hepcidin down-regulates intestinal transepithelial iron transport.	Iron	195-199	hepcidin antimicrobial peptide	Mus musculus	144-152
21346101-2	2011	Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2.	Iron	0-4	telomeric repeat binding factor 2	Homo sapiens	92-96
21421406-3	2011	Enhanced activities of PEPC and/or NADP-ME and/or PPDK were found in plants under various types of abiotic stress, such as drought, high salt concentration, ozone, the absence of phosphate and iron or the presence of heavy metals in the soil.	Iron	193-197	malic enzyme 1	Homo sapiens	35-42
21189251-0	2011	Co-precipitation of phosphate and iron limits mitochondrial phosphate availability in Saccharomyces cerevisiae lacking the yeast frataxin homologue (YFH1).	Iron	34-38	ferroxidase	Saccharomyces cerevisiae S288C	149-153
21292982-3	2011	We demonstrate that the unique iron-sulfur cluster domain and an ATP-dependent conformational switch of ABCE1 are essential both for ribosome binding and recycling.	Iron	31-35	ATP binding cassette subfamily E member 1	Homo sapiens	104-109
21115478-1	2011	Iron storage in yeast requires the activity of the vacuolar iron transporter Ccc1.	Iron	0-4	Ccc1p	Saccharomyces cerevisiae S288C	77-81
21115478-2	2011	Yeast with an intact CCC1 are resistant to iron toxicity, but deletion of CCC1 renders yeast susceptible to iron toxicity.	Iron	108-112	Ccc1p	Saccharomyces cerevisiae S288C	74-78
21131439-4	2011	There are three types of iron-responsive transcriptional regulators in fungi; Aft1/Aft2 activators in yeast, GATA-type repressors in many fungi, and HapX/Php4 in Schizosaccharomyces pombe and Aspergillus species.	Iron	25-29	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	78-82
20502350-1	2011	BACKGROUND: The metabolic fates of copper and iron are closely linked through ceruloplasmin and hephaestin.	Iron	46-50	hephaestin	Homo sapiens	96-106
20502350-4	2011	Animal studies suggest hypoceruloplasminemia and impaired hephaestin function result in tissue iron accumulation.	Iron	95-99	hephaestin	Homo sapiens	58-68
21187450-2	2011	Although our previous studies have shown that hemojuvelin regulates hepcidin expression and iron metabolism through the BMP pathway, the role of the BMP signaling mediated by Dragon remains largely unknown.	Iron	92-96	hemojuvelin BMP co-receptor	Mus musculus	46-57
21194630-1	2011	Heme oxygenase (HO) catalyses the degradation of heme to biliverdin, carbon monoxide (CO) and ferrous iron via three successive monooxygenase reactions, using electrons provided by NADPH-cytochrome P450 reductase (CPR) and oxygen molecules.	Iron	94-106	cytochrome p450 oxidoreductase	Rattus norvegicus	181-212
21194630-1	2011	Heme oxygenase (HO) catalyses the degradation of heme to biliverdin, carbon monoxide (CO) and ferrous iron via three successive monooxygenase reactions, using electrons provided by NADPH-cytochrome P450 reductase (CPR) and oxygen molecules.	Iron	94-106	cytochrome p450 oxidoreductase	Rattus norvegicus	214-217
21394295-6	2011	RESULTS: The up-regulated genes on day 7 by hPDL cells cultured in osteogenic medium were thought to be associated with calcium/iron/metal ion binding or homeostasis (PDE1A, HFE and PCDH9) and cell viability (PCDH9), and the down-regulated genes were thought to be associated with proliferation (PHGDH and PSAT1).	Iron	128-132	phosphodiesterase 1A	Homo sapiens	167-172
21164132-8	2011	Iron accumulation was associated with upregulation of heme oxygenase-1 and ferritin.	Iron	0-4	heme oxygenase 1	Rattus norvegicus	54-70
21405349-1	2011	Recently, experimental studies of the spin excitation spectrum revealed a strong temperature dependence in the normal state and a resonance feature in the superconducting state of several Fe-based superconductors.	Iron	188-190	spindlin 1	Homo sapiens	38-42
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	71-75	Bol2p	Saccharomyces cerevisiae S288C	41-45
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	71-75	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	109-113
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	152-156	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	30-34
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	152-156	Bol2p	Saccharomyces cerevisiae S288C	41-45
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	152-156	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	109-113
20978135-3	2011	We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	101-105	Bol2p	Saccharomyces cerevisiae S288C	30-34
20978135-3	2011	We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	101-105	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	39-43
20978135-3	2011	We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	101-105	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	154-158
20978135-4	2011	To further characterize this unusual Fe-S-binding complex, site-directed mutagenesis was used to identify specific residues in Fra2 that influence Fe-S cluster binding and regulation of Aft1 activity in vivo.	Iron	37-41	Bol2p	Saccharomyces cerevisiae S288C	127-131
20978135-4	2011	To further characterize this unusual Fe-S-binding complex, site-directed mutagenesis was used to identify specific residues in Fra2 that influence Fe-S cluster binding and regulation of Aft1 activity in vivo.	Iron	37-41	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	186-190
20978135-4	2011	To further characterize this unusual Fe-S-binding complex, site-directed mutagenesis was used to identify specific residues in Fra2 that influence Fe-S cluster binding and regulation of Aft1 activity in vivo.	Iron	147-151	Bol2p	Saccharomyces cerevisiae S288C	127-131
20978135-5	2011	Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex.	Iron	67-69	Bol2p	Saccharomyces cerevisiae S288C	56-60
20978135-5	2011	Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex.	Iron	67-69	Bol2p	Saccharomyces cerevisiae S288C	94-98
20978135-5	2011	Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex.	Iron	67-69	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	99-103
20978135-7	2011	In vivo genetic studies further confirm that Fra2 His-103 is critical for control of Aft1 activity in response to the cellular iron status.	Iron	127-131	Bol2p	Saccharomyces cerevisiae S288C	45-49
20978135-7	2011	In vivo genetic studies further confirm that Fra2 His-103 is critical for control of Aft1 activity in response to the cellular iron status.	Iron	127-131	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	85-89
20978135-9	2011	Taken together, these results demonstrate that the histidine coordination and stability of the [2Fe-2S] cluster in the Fra2-Grx3 complex are essential for iron regulation in yeast.	Iron	155-159	Bol2p	Saccharomyces cerevisiae S288C	119-123
20978135-9	2011	Taken together, these results demonstrate that the histidine coordination and stability of the [2Fe-2S] cluster in the Fra2-Grx3 complex are essential for iron regulation in yeast.	Iron	155-159	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	124-128
21212352-2	2011	The pressure-induced iron spin state transition in the lower mantle may influence seismic wave velocities by changing the elasticity of iron-bearing minerals, but no seismological evidence of an anomaly exists.	Iron	21-25	spindlin 1	Homo sapiens	26-30
21212352-2	2011	The pressure-induced iron spin state transition in the lower mantle may influence seismic wave velocities by changing the elasticity of iron-bearing minerals, but no seismological evidence of an anomaly exists.	Iron	136-140	spindlin 1	Homo sapiens	26-30
20811044-0	2011	Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.	Iron	22-26	hepcidin antimicrobial peptide	Mus musculus	60-68
20811044-2	2011	The peptide hormone hepcidin (Hepc) limits iron uptake from the intestine by triggering degradation of the iron transporter ferroportin (Fpn).	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	20-28
20811044-2	2011	The peptide hormone hepcidin (Hepc) limits iron uptake from the intestine by triggering degradation of the iron transporter ferroportin (Fpn).	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	30-34
20811044-8	2011	RESULTS: Hepc(-/-) mice experienced age-dependent increases in retinal iron followed by retinal degeneration with autofluorescent RPE, photoreceptor death, and subretinal neovascularization.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	9-13
20811044-10	2011	Conversely, in cultured retinal capillary endothelial cells, exogenous Hepc decreased both Fpn levels and iron transport.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	71-75
20811044-11	2011	The retina can sense increased iron levels, upregulating Hepc after phosphorylation of extracellular signal regulated kinases.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	57-61
20811044-12	2011	CONCLUSIONS: These findings indicate that Hepc is essential for retinal iron regulation.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	42-46
20811044-14	2011	Increases in Hepc mRNA levels after intravitreal iron injection combined with Hepc-mediated decreases in iron export from cultured retinal capillary endothelial cells suggest that the retina may use Hepc for its tissue-specific iron regulation.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	13-17
20811044-14	2011	Increases in Hepc mRNA levels after intravitreal iron injection combined with Hepc-mediated decreases in iron export from cultured retinal capillary endothelial cells suggest that the retina may use Hepc for its tissue-specific iron regulation.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	78-82
20811044-14	2011	Increases in Hepc mRNA levels after intravitreal iron injection combined with Hepc-mediated decreases in iron export from cultured retinal capillary endothelial cells suggest that the retina may use Hepc for its tissue-specific iron regulation.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	78-82
20811044-14	2011	Increases in Hepc mRNA levels after intravitreal iron injection combined with Hepc-mediated decreases in iron export from cultured retinal capillary endothelial cells suggest that the retina may use Hepc for its tissue-specific iron regulation.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	78-82
20811044-14	2011	Increases in Hepc mRNA levels after intravitreal iron injection combined with Hepc-mediated decreases in iron export from cultured retinal capillary endothelial cells suggest that the retina may use Hepc for its tissue-specific iron regulation.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	78-82
20618233-5	2011	During the next 3 years (period 2), patients were treated with ESAs and need-based, continuous, low-dose iron.	Iron	105-109	period circadian regulator 2	Homo sapiens	25-33
20618233-10	2011	The use of ESAs did not change significantly during period 2 in comparison with period 1, while the use of iron was significantly lower in period 2.	Iron	107-111	period circadian regulator 2	Homo sapiens	139-147
20618233-11	2011	Significantly lower values were obtained for serum ferritin, saturation of transferrin, serum iron, and total serum iron-binding capacity during period 2.	Iron	116-120	period circadian regulator 2	Homo sapiens	145-153
20881209-5	2011	Prkag1(-/-) mice displayed splenomegaly and iron accumulation due to compensatory splenic erythropoiesis and erythrophagocytosis.	Iron	44-48	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	Mus musculus	0-6
22264719-2	2011	Hepcidin, a key regulator           of iron metabolism, is up-regulated by iron and inflammatory           stimuli such as interleukin 6, and decreased           by iron deficiency, enhanced erythropoiesis           and hypoxia.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	0-8
22264719-2	2011	Hepcidin, a key regulator           of iron metabolism, is up-regulated by iron and inflammatory           stimuli such as interleukin 6, and decreased           by iron deficiency, enhanced erythropoiesis           and hypoxia.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	0-8
22203788-4	2011	Meanwhile, 46 operons were found to be regulated by the Fur transcription regulator in Clostridium botulinum A ATCC 3502, involved in several functional classifications, including iron acquisition, iron utilization, iron transport, and transcription regulator.	Iron	180-184	transcriptional repressor	Clostridium botulinum A str. ATCC 3502	56-59
22203788-4	2011	Meanwhile, 46 operons were found to be regulated by the Fur transcription regulator in Clostridium botulinum A ATCC 3502, involved in several functional classifications, including iron acquisition, iron utilization, iron transport, and transcription regulator.	Iron	198-202	transcriptional repressor	Clostridium botulinum A str. ATCC 3502	56-59
22203788-4	2011	Meanwhile, 46 operons were found to be regulated by the Fur transcription regulator in Clostridium botulinum A ATCC 3502, involved in several functional classifications, including iron acquisition, iron utilization, iron transport, and transcription regulator.	Iron	198-202	transcriptional repressor	Clostridium botulinum A str. ATCC 3502	56-59
22203788-5	2011	Under an iron-restricted medium, we experimentally found that a Fur transcription regulator (CBO1372) and two operons (DedA, CBO2610-CBO2614 and ABC transporter, CBO0845-CBO0847) are shown to be differentially expressed in Clostridium botulinum A ATCC 3502.	Iron	9-13	transcriptional repressor	Clostridium botulinum A str. ATCC 3502	64-67
21852895-0	2011	FERROCHELATASE: THE CONVERGENCE OF THE PORPHYRIN BIOSYNTHESIS AND IRON TRANSPORT PATHWAYS.	Iron	66-70	ferrochelatase	Homo sapiens	0-14
21852895-1	2011	Ferrochelatase (also known as PPIX ferrochelatase; Enzyme Commission number 4.9.9.1.1) catalyzes the insertion of ferrous iron into PPIX to form heme.	Iron	114-126	ferrochelatase	Homo sapiens	0-14
20946915-6	2011	The Mn/Fe ratio (MIR) in plasma or erythrocytes reflects not only steady-state concentrations of Mn or Fe in tested individuals, but also a biological response (altered Fe homeostasis) to Mn exposure.	Iron	7-9	membrane associated ring-CH-type finger 8	Homo sapiens	17-20
20946915-6	2011	The Mn/Fe ratio (MIR) in plasma or erythrocytes reflects not only steady-state concentrations of Mn or Fe in tested individuals, but also a biological response (altered Fe homeostasis) to Mn exposure.	Iron	103-105	membrane associated ring-CH-type finger 8	Homo sapiens	17-20
20946915-6	2011	The Mn/Fe ratio (MIR) in plasma or erythrocytes reflects not only steady-state concentrations of Mn or Fe in tested individuals, but also a biological response (altered Fe homeostasis) to Mn exposure.	Iron	103-105	membrane associated ring-CH-type finger 8	Homo sapiens	17-20
21146130-1	2011	OBJECTIVE: To evaluate the transepithelial transport of sodium, glucose, potassium, and water and the mRNA level of the sodium-glucose cotransporter (SGLT1) and the facilitated sugar transporter (GLUT2) in the small intestine of iron-deficient rats.	Iron	229-233	solute carrier family 5 member 1	Rattus norvegicus	150-155
21146130-8	2011	CONCLUSION: Iron deficiency decreases the absorption of glucose, sodium, and water and increases SGLT1 mRNA in the intermediate and distal segments of the small intestine of rats.	Iron	12-16	solute carrier family 5 member 1	Rattus norvegicus	97-102
20966079-1	2010	Ferrochelatase catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme.	Iron	42-54	ferrochelatase	Mus musculus	0-14
20889785-1	2010	Grx3 and Grx4 are two monothiol glutaredoxins of Saccharomyces cerevisiae that have previously been characterized as regulators of Aft1 localization and therefore of iron homeostasis.	Iron	166-170	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	0-4
21088898-7	2010	Subsequent molecular characterization of the ETFDH gene revealed novel heterozygous mutations, p.G274X:c.820 G &gt; T (exon 7) and p.P534L: c.1601 C &gt; T (exon 12), the latter within the iron sulfur-cluster and predicted to affect ubiquinone reductase activity of ETFDH and the docking of ETF to ETFDH.	Iron	189-193	electron transfer flavoprotein dehydrogenase	Homo sapiens	45-50
20695822-5	2010	Interestingly, the Aft1-dependent iron regulon is a main target of PDTC, indicating a lack of iron availability.	Iron	34-38	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	19-23
20695822-9	2010	Hence, we show that PDTC induces cytoplasmic zinc excess, eliciting vacuolar detoxification, which in turn, disturbs iron homeostasis and activates the iron-dependent regulator Aft1.	Iron	152-156	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	177-181
20638175-6	2010	Thus the HC1 extraction might be a better choice for the evaluation of the redox state of iron in MSW.	Iron	90-94	CYCS pseudogene 39	Homo sapiens	9-12
20740487-0	2010	Response to: ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation.	Iron	74-78	ATPase cation transporting 13A2	Homo sapiens	13-20
20740487-0	2010	Response to: ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation.	Iron	74-78	ATPase cation transporting 13A2	Homo sapiens	32-37
20678169-8	2010	In the pig, SERPINA14 is involved in iron transport to the fetus by binding to and stabilizing the iron-binding protein uteroferrin.	Iron	37-41	acid phosphatase 5, tartrate resistant	Sus scrofa	120-131
20678169-8	2010	In the pig, SERPINA14 is involved in iron transport to the fetus by binding to and stabilizing the iron-binding protein uteroferrin.	Iron	99-103	acid phosphatase 5, tartrate resistant	Sus scrofa	120-131
20890083-2	2010	They were all encapsulated, motile, capable of producing toxins and utilizing transferrin-bound iron, cytotoxic to cultured cells, and virulent enough to kill mice.	Iron	96-100	transferrin	Mus musculus	78-89
20666399-6	2010	In vertebrates, the proposed catalytic mechanism of SO involves two intramolecular one-electron transfer (IET) steps from the molybdenum cofactor to the iron of the integral b-type heme.	Iron	153-157	sulfite oxidase	Homo sapiens	52-54
20599839-8	2010	HO-1 was predominantly induced in oligodendrocytes during the early stage of demyelination in the dmy rat, suggesting that iron-mediated oxidative stress is most likely involved in the pathogenesis of demyelination in the dmy rat.	Iron	123-127	heme oxygenase 1	Rattus norvegicus	0-4
20519508-2	2010	Having previously shown that the functional expression of NRAMP-1 results in increased protein phosphorylation mediated in part by an iron-dependent inhibition of Mvarphi protein-tyrosine phosphatase (PTP) activity, we sought to study the mechanism(s) underlying this specific event.	Iron	134-138	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	171-199
20519508-2	2010	Having previously shown that the functional expression of NRAMP-1 results in increased protein phosphorylation mediated in part by an iron-dependent inhibition of Mvarphi protein-tyrosine phosphatase (PTP) activity, we sought to study the mechanism(s) underlying this specific event.	Iron	134-138	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	201-204
20519508-3	2010	Herein we have identified the mononuclear dicitrate iron complex [Fe(cit)(2)H(4-x)]((1+x)-) as the species responsible for the specific inhibition of Mvarphi PTP activity.	Iron	52-56	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	158-161
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	homeostatic iron regulator	Mus musculus	103-106
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	transferrin receptor 2	Mus musculus	108-130
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	transferrin receptor 2	Mus musculus	132-136
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	hemojuvelin BMP co-receptor	Mus musculus	143-154
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	hemojuvelin BMP co-receptor	Mus musculus	156-159
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	208-216
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	208-216
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hepcidin antimicrobial peptide	Mus musculus	38-46
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	homeostatic iron regulator	Mus musculus	103-106
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hemojuvelin BMP co-receptor	Mus musculus	143-154
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hemojuvelin BMP co-receptor	Mus musculus	156-159
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hepcidin antimicrobial peptide	Mus musculus	38-46
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	homeostatic iron regulator	Mus musculus	103-106
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hemojuvelin BMP co-receptor	Mus musculus	143-154
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hemojuvelin BMP co-receptor	Mus musculus	156-159
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hepcidin antimicrobial peptide	Mus musculus	38-46
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	homeostatic iron regulator	Mus musculus	103-106
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hemojuvelin BMP co-receptor	Mus musculus	143-154
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	198-202	hemojuvelin BMP co-receptor	Mus musculus	156-159
20220061-1	2010	BACKGROUND: Expression of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and is decreased by hepcidin.	Iron	30-34	hepcidin antimicrobial peptide	Mus musculus	142-150
20581821-7	2010	As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues.	Iron	241-245	sorcin	Homo sapiens	86-89
20581821-7	2010	As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues.	Iron	241-245	lipocalin 2	Homo sapiens	90-94
20581821-7	2010	As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues.	Iron	241-245	sorcin	Homo sapiens	186-189
20581821-7	2010	As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues.	Iron	241-245	lipocalin 2	Homo sapiens	190-194
20427704-1	2010	In erythroid cells, ferrous iron is imported into the mitochondrion by mitoferrin-1 (Mfrn1).	Iron	28-32	solute carrier family 25 member 37	Homo sapiens	71-83
20427704-1	2010	In erythroid cells, ferrous iron is imported into the mitochondrion by mitoferrin-1 (Mfrn1).	Iron	28-32	solute carrier family 25 member 37	Homo sapiens	85-90
20427704-2	2010	Previously, we showed that Mfrn1 interacts with Abcb10 to enhance mitochondrial iron importation.	Iron	80-84	solute carrier family 25 member 37	Homo sapiens	27-32
20427704-4	2010	Fech is the terminal heme synthesis enzyme to catalyze the insertion of the imported iron into protoporphyrin IX to produce heme.	Iron	85-89	ferrochelatase	Homo sapiens	0-4
20427704-7	2010	Our findings imply that Fech forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.	Iron	122-126	ferrochelatase	Homo sapiens	24-28
20427704-7	2010	Our findings imply that Fech forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.	Iron	122-126	solute carrier family 25 member 37	Homo sapiens	62-67
20478358-6	2010	The FTL mouse exhibits buildup of iron in the brain and presents manifestations of oxidative stress reminiscent of the human disease.	Iron	34-38	ferritin light polypeptide 1	Mus musculus	4-7
20482313-7	2010	Following iron depletion, elevated Spry4 levels were detected in several cell types independent of tissue origin, presence of mitogens, cell differentiation and malignancy.	Iron	10-14	sprouty RTK signaling antagonist 4	Homo sapiens	35-40
20482313-11	2010	However, the functional significance of the observed upregulation of Spry4 during iron depletion remains to be clarified.	Iron	82-86	sprouty RTK signaling antagonist 4	Homo sapiens	69-74
20338170-4	2010	RESULTS: At 6-8 months after OLT, Hfe(-/-) mice that received Hfe(-/-) livers maintained the hemochromatosis phenotype: iron accumulation in hepatocytes but not Kupffer cells (KC), increased transferrin levels, and low levels of iron in the spleen.	Iron	120-124	homeostatic iron regulator	Mus musculus	34-37
20338170-4	2010	RESULTS: At 6-8 months after OLT, Hfe(-/-) mice that received Hfe(-/-) livers maintained the hemochromatosis phenotype: iron accumulation in hepatocytes but not Kupffer cells (KC), increased transferrin levels, and low levels of iron in the spleen.	Iron	229-233	homeostatic iron regulator	Mus musculus	34-37
20338170-5	2010	Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen.	Iron	68-72	homeostatic iron regulator	Mus musculus	0-3
20338170-5	2010	Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen.	Iron	68-72	homeostatic iron regulator	Mus musculus	28-31
20338170-5	2010	Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen.	Iron	110-114	homeostatic iron regulator	Mus musculus	0-3
20338170-5	2010	Hfe(+/+) mice that received Hfe(-/-) livers had increased levels of iron in serum and liver and low levels of iron in spleen.	Iron	110-114	homeostatic iron regulator	Mus musculus	28-31
20338170-7	2010	Transplantation of Hfe(+/+) livers into Hfe(-/-) mice prevented hepatic iron accumulation but did not return spleen and plasma levels of iron to normal; KCs still appeared to be iron poor, despite normal hepcidin expression.	Iron	72-76	homeostatic iron regulator	Mus musculus	19-22
20338170-8	2010	CONCLUSIONS: In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine).	Iron	89-93	homeostatic iron regulator	Mus musculus	62-65
20338170-8	2010	CONCLUSIONS: In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine).	Iron	89-93	homeostatic iron regulator	Mus musculus	62-65
20338170-10	2010	These findings indicate an independent, iron-modifying effect of HFE in KCs.	Iron	40-44	homeostatic iron regulator	Mus musculus	65-68
20439772-0	2010	Functional genomics analysis of the Saccharomyces cerevisiae iron responsive transcription factor Aft1 reveals iron-independent functions.	Iron	61-65	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	98-102
20439772-0	2010	Functional genomics analysis of the Saccharomyces cerevisiae iron responsive transcription factor Aft1 reveals iron-independent functions.	Iron	111-115	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	98-102
20439772-1	2010	The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate the increase of iron uptake and remodel cellular metabolism to survive low-iron conditions.	Iron	71-75	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	50-54
20439772-1	2010	The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate the increase of iron uptake and remodel cellular metabolism to survive low-iron conditions.	Iron	120-124	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	50-54
20439772-1	2010	The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate the increase of iron uptake and remodel cellular metabolism to survive low-iron conditions.	Iron	120-124	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	50-54
20439772-1	2010	The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate the increase of iron uptake and remodel cellular metabolism to survive low-iron conditions.	Iron	120-124	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	50-54
20439772-6	2010	We demonstrate that Aft1 works in parallel with the RIM101 pH pathway and the role of Aft1 in DNA damage repair is mediated by iron.	Iron	127-131	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	86-90
20530874-1	2010	Hepcidin is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	0-8
20530874-3	2010	Hepcidin mediates iron homeostasis by binding to the iron exporter ferroportin, inducing its internalization and degradation via activation of the protein kinase Jak2 and the subsequent phosphorylation of ferroportin.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
20530874-3	2010	Hepcidin mediates iron homeostasis by binding to the iron exporter ferroportin, inducing its internalization and degradation via activation of the protein kinase Jak2 and the subsequent phosphorylation of ferroportin.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	0-8
20210929-6	2010	Instead, iron-deficient subjects" GDF15 levels were slightly lower than those measured in the control group of subjects (307 +/- 90 and 386 +/- 104 pg/mL, respectively).	Iron	9-13	growth differentiation factor 15	Homo sapiens	34-39
20547883-3	2010	The high protein sequence similarity between Fdx1 and its yeast adrenodoxin homologue (Yah1) suggested that Fdx1, like Yah1, may be involved in the biosynthesis of heme A and Fe/S clusters, two versatile and essential protein cofactors.	Iron	175-178	ferredoxin 1	Homo sapiens	45-49
20547883-3	2010	The high protein sequence similarity between Fdx1 and its yeast adrenodoxin homologue (Yah1) suggested that Fdx1, like Yah1, may be involved in the biosynthesis of heme A and Fe/S clusters, two versatile and essential protein cofactors.	Iron	175-178	ferredoxin 1	Homo sapiens	108-112
20461823-4	2010	Significant bond-length changes were observed for the Fe-ligand bonds (up to 0.19 A), the cyano bonds (up to 0.09 A), and the lanthanide-ligand bonds (up to 0.10 A).	Iron	54-56	SLAM family member 7	Homo sapiens	79-83
20129729-4	2010	We observed the formation of surface Fe(II)-CS/GLA complex using microscopic analyses and identified Fe oxidation (Fe(II) to Fe(III)) coupled with H(2)O(2) reduction on the Fe(II)-CS/GLA surfaces during the modified Fenton reaction.	Iron	37-39	galactosidase alpha	Homo sapiens	47-50
20307653-1	2010	Yeast cells deficient in the yeast frataxin homolog (Yfh1p) accumulate iron in their mitochondria.	Iron	71-75	ferroxidase	Saccharomyces cerevisiae S288C	53-58
20307653-4	2010	Increasing the ratio of mitochondrial iron-to-Yfh1p by decreasing the steady-state level of Yfh1p to less than 100 molecules per cell had very few deleterious effects on cell physiology, even though the mitochondrial iron concentration greatly exceeded the iron-binding capacity of Yfh1p in these conditions.	Iron	38-42	ferroxidase	Saccharomyces cerevisiae S288C	92-97
20307653-4	2010	Increasing the ratio of mitochondrial iron-to-Yfh1p by decreasing the steady-state level of Yfh1p to less than 100 molecules per cell had very few deleterious effects on cell physiology, even though the mitochondrial iron concentration greatly exceeded the iron-binding capacity of Yfh1p in these conditions.	Iron	38-42	ferroxidase	Saccharomyces cerevisiae S288C	92-97
20307653-4	2010	Increasing the ratio of mitochondrial iron-to-Yfh1p by decreasing the steady-state level of Yfh1p to less than 100 molecules per cell had very few deleterious effects on cell physiology, even though the mitochondrial iron concentration greatly exceeded the iron-binding capacity of Yfh1p in these conditions.	Iron	217-221	ferroxidase	Saccharomyces cerevisiae S288C	46-51
20307653-4	2010	Increasing the ratio of mitochondrial iron-to-Yfh1p by decreasing the steady-state level of Yfh1p to less than 100 molecules per cell had very few deleterious effects on cell physiology, even though the mitochondrial iron concentration greatly exceeded the iron-binding capacity of Yfh1p in these conditions.	Iron	217-221	ferroxidase	Saccharomyces cerevisiae S288C	46-51
20127499-1	2010	Heme oxygenase-1 (HO-1) catalyses the rate-limiting step of heme degradation to biliverdin, which is in turn reduced to bilirubin, CO and free iron.	Iron	143-147	heme oxygenase 1	Rattus norvegicus	0-16
20127499-1	2010	Heme oxygenase-1 (HO-1) catalyses the rate-limiting step of heme degradation to biliverdin, which is in turn reduced to bilirubin, CO and free iron.	Iron	143-147	heme oxygenase 1	Rattus norvegicus	18-22
20304921-1	2010	STEAP4 is a plasma membrane metalloreductase involved in the transport of iron and copper.	Iron	74-78	STEAP family member 4	Mus musculus	0-6
20499961-1	2010	First principles studies on the ground state structure, binding energy, spin multiplicity, and the noncollinearity of local spin moments in Fe(n) and Fe(n) (-) clusters and their oxides, viz., Fe(n)O(2) and Fe(n)O(2) (-) have been carried out within a density functional formalism.	Iron	140-145	spindlin 1	Homo sapiens	124-128
20499961-1	2010	First principles studies on the ground state structure, binding energy, spin multiplicity, and the noncollinearity of local spin moments in Fe(n) and Fe(n) (-) clusters and their oxides, viz., Fe(n)O(2) and Fe(n)O(2) (-) have been carried out within a density functional formalism.	Iron	150-155	spindlin 1	Homo sapiens	124-128
20424773-0	2010	Spin crossover in co-crystallised 2 ratio 1 cisratiotrans [Fe(II)(pldpt)(2)(NCS)(2)] occurs only in (1/3) of the iron centres.	Iron	113-117	spindlin 1	Homo sapiens	0-4
20424773-1	2010	The first spin crossover (SCO) active sample of co-crystallised stereoisomers (cisratiotrans, 2 ratio 1) is fully high spin (HS) at room temperature but displays temperature mediated SCO in which only a third of the iron(ii) centres change spin state.	Iron	216-220	spindlin 1	Homo sapiens	10-14
20026081-0	2010	AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress.	Iron	102-106	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	0-4
20026081-10	2010	These results demonstrate that ILQ has the ability to protect cells from AA+iron-induced H2O2 production and mitochondrial dysfunction, which is mediated with GSK3beta phosphorylation downstream of AMPK.	Iron	76-80	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	198-202
20182355-7	2010	As GDF15 is a transforming growth factor-beta superfamily member, it was investigated as an effector of ineffective erythropoiesis that suppresses hepcidin expression despite iron overloading.	Iron	175-179	growth differentiation factor 15	Homo sapiens	3-8
20182355-9	2010	In patients with thalassemia and related anemias, GDF15 expression may contribute to iron overloading or other features of the disease phenotype.	Iron	85-89	growth differentiation factor 15	Homo sapiens	50-55
20224575-3	2010	Here, we report that existence of the Hsp70 Ssq1, which arose by duplication of the gene encoding multifunction mtHsp70 and specializes in iron-sulphur cluster biogenesis, correlates with functional and structural changes in the J domain of its J-protein partner Jac1.	Iron	139-143	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	263-267
20302570-0	2010	Iron-binding activity of human iron-sulfur cluster assembly protein hIscA1.	Iron	31-35	iron-sulfur cluster assembly 1	Homo sapiens	68-74
20302570-1	2010	A human homologue of the iron-sulfur cluster assembly protein IscA (hIscA1) has been cloned and expressed in Escherichia coli cells.	Iron	25-29	iron-sulfur cluster assembly 1	Homo sapiens	68-74
20302570-2	2010	The UV-visible absorption and EPR (electron paramagnetic resonance) measurements reveal that hIscA1 purified from E. coli cells contains a mononuclear iron centre and that the iron binding in hIscA1 expressed in E. coli cells can be further modulated by the iron content in the cell growth medium.	Iron	151-155	iron-sulfur cluster assembly 1	Homo sapiens	93-99
20302570-2	2010	The UV-visible absorption and EPR (electron paramagnetic resonance) measurements reveal that hIscA1 purified from E. coli cells contains a mononuclear iron centre and that the iron binding in hIscA1 expressed in E. coli cells can be further modulated by the iron content in the cell growth medium.	Iron	151-155	iron-sulfur cluster assembly 1	Homo sapiens	192-198
20302570-2	2010	The UV-visible absorption and EPR (electron paramagnetic resonance) measurements reveal that hIscA1 purified from E. coli cells contains a mononuclear iron centre and that the iron binding in hIscA1 expressed in E. coli cells can be further modulated by the iron content in the cell growth medium.	Iron	176-180	iron-sulfur cluster assembly 1	Homo sapiens	93-99
20302570-2	2010	The UV-visible absorption and EPR (electron paramagnetic resonance) measurements reveal that hIscA1 purified from E. coli cells contains a mononuclear iron centre and that the iron binding in hIscA1 expressed in E. coli cells can be further modulated by the iron content in the cell growth medium.	Iron	176-180	iron-sulfur cluster assembly 1	Homo sapiens	192-198
20302570-2	2010	The UV-visible absorption and EPR (electron paramagnetic resonance) measurements reveal that hIscA1 purified from E. coli cells contains a mononuclear iron centre and that the iron binding in hIscA1 expressed in E. coli cells can be further modulated by the iron content in the cell growth medium.	Iron	176-180	iron-sulfur cluster assembly 1	Homo sapiens	93-99
20302570-2	2010	The UV-visible absorption and EPR (electron paramagnetic resonance) measurements reveal that hIscA1 purified from E. coli cells contains a mononuclear iron centre and that the iron binding in hIscA1 expressed in E. coli cells can be further modulated by the iron content in the cell growth medium.	Iron	176-180	iron-sulfur cluster assembly 1	Homo sapiens	192-198
20302570-3	2010	Additional studies show that purified hIscA1 binds iron with an iron association constant of approx.	Iron	51-55	iron-sulfur cluster assembly 1	Homo sapiens	38-44
20302570-3	2010	Additional studies show that purified hIscA1 binds iron with an iron association constant of approx.	Iron	64-68	iron-sulfur cluster assembly 1	Homo sapiens	38-44
20302570-4	2010	2x1019 M-1, and that the iron-bound hIscA1 is able to provide the iron for the iron-sulfur cluster assembly in a proposed scaffold protein, IscU of E. coli, in vitro.	Iron	25-29	iron-sulfur cluster assembly 1	Homo sapiens	36-42
20302570-4	2010	2x1019 M-1, and that the iron-bound hIscA1 is able to provide the iron for the iron-sulfur cluster assembly in a proposed scaffold protein, IscU of E. coli, in vitro.	Iron	66-70	iron-sulfur cluster assembly 1	Homo sapiens	36-42
20302570-4	2010	2x1019 M-1, and that the iron-bound hIscA1 is able to provide the iron for the iron-sulfur cluster assembly in a proposed scaffold protein, IscU of E. coli, in vitro.	Iron	66-70	iron-sulfur cluster assembly 1	Homo sapiens	36-42
20302570-6	2010	The results suggest that hIscA1, like E. coli IscA, is an iron-binding protein that may act as an iron chaperone for biogenesis of iron-sulfur clusters.	Iron	58-62	iron-sulfur cluster assembly 1	Homo sapiens	25-31
20302570-6	2010	The results suggest that hIscA1, like E. coli IscA, is an iron-binding protein that may act as an iron chaperone for biogenesis of iron-sulfur clusters.	Iron	98-102	iron-sulfur cluster assembly 1	Homo sapiens	25-31
20219396-1	2010	Transcription of the hepcidin (Hamp) gene is controlled by iron stores and the rate of erythropoiesis.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	21-29
20219396-1	2010	Transcription of the hepcidin (Hamp) gene is controlled by iron stores and the rate of erythropoiesis.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	31-35
20219396-8	2010	Pretreatment of C57BL/6 mice with iron (5mg/mouse) almost completely inhibited the EPO-induced decrease of Hamp mRNA.	Iron	34-38	hepcidin antimicrobial peptide	Mus musculus	107-111
20368581-6	2010	Iron chelating agents induce expression and phosphorylation of the VD receptor (VDR), and iron deprivation and VD act synergistically.	Iron	0-4	vitamin D receptor	Homo sapiens	67-78
20368581-6	2010	Iron chelating agents induce expression and phosphorylation of the VD receptor (VDR), and iron deprivation and VD act synergistically.	Iron	0-4	vitamin D receptor	Homo sapiens	80-83
20463934-0	2010	Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells.	Iron	0-4	asialoglycoprotein receptor 1	Mus musculus	112-115
20463934-2	2010	Nanoparticles of iron labeled with Texas Red are introduced in cultures of nonbeating mouse cardiac cells (HL1-NB) with or without 7-ketocholesterol 7KC, and their ability to induce cell death, pro-inflammatory and oxidative effects are analyzed simultaneously.	Iron	17-21	asialoglycoprotein receptor 1	Mus musculus	107-110
20361867-7	2010	In the absence of external ligands, the heme ferrous iron of GLB-26 is strongly hexacoordinated with HisE7, which could explain its extremely low affinity for CO.	Iron	53-57	Globin-like protein 26	Caenorhabditis elegans	61-67
19838709-5	2010	Patients who had null genotype for both the alleles, i.e., GSTT1/GSTM1 had significantly higher levels of serum iron (P = 0.007) and serum ferritin (P = 0.001) than patients with normal genotype for GST deletions.	Iron	112-116	glutathione S-transferase theta 1	Homo sapiens	59-64
20040761-0	2010	SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	56-64
20040761-1	2010	Hepcidin is the master regulatory hormone of systemic iron metabolism.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	0-8
20040761-2	2010	Hepcidin deficiency causes common iron overload syndromes whereas its overexpression is responsible for microcytic anemias.	Iron	34-38	hepcidin antimicrobial peptide	Mus musculus	0-8
20040761-5	2010	SMAD7 is an inhibitory SMAD protein that mediates a negative feedback loop to both transforming growth factor-beta and BMP signaling and that recently was shown to be coregulated with hepcidin via SMAD4 in response to altered iron availability in vivo.	Iron	226-230	hepcidin antimicrobial peptide	Mus musculus	184-192
20164366-10	2010	To examine potential mediators of the reduced hepcidin expression in CuD rats, we measured levels of hepatic transferrin receptor 2 (TfR2), a putative iron sensor that links holotransferrin to hepcidin production, and transcript abundance of bone morphogenic protein 6 (BMP6), a key endogenous positive regulator of hepcidin production.	Iron	151-155	transferrin receptor 2	Rattus norvegicus	109-131
20164366-10	2010	To examine potential mediators of the reduced hepcidin expression in CuD rats, we measured levels of hepatic transferrin receptor 2 (TfR2), a putative iron sensor that links holotransferrin to hepcidin production, and transcript abundance of bone morphogenic protein 6 (BMP6), a key endogenous positive regulator of hepcidin production.	Iron	151-155	transferrin receptor 2	Rattus norvegicus	133-137
20075041-4	2010	Since iron and haem uptake genes, and other known virulence factors, constitute the majority of the iron- and haem-regulated gene set, we postulated that tehB may play a role in nutrient acquisition and/or the virulence of H. influenzae.	Iron	6-10	SAM-dependent methyltransferase TehB	Haemophilus influenzae Rd KW20	154-158
20075041-4	2010	Since iron and haem uptake genes, and other known virulence factors, constitute the majority of the iron- and haem-regulated gene set, we postulated that tehB may play a role in nutrient acquisition and/or the virulence of H. influenzae.	Iron	100-104	SAM-dependent methyltransferase TehB	Haemophilus influenzae Rd KW20	154-158
19943190-7	2010	Results indicate that TfR, H-ferritin, and IRP2 mRNA expression was differentially affected by aging and by neonatal iron treatment in all three brain regions.	Iron	117-121	iron responsive element binding protein 2	Rattus norvegicus	43-47
20113438-2	2010	By using a proteomic approach, we identified the ubiquitin-conjugating enzyme UBC13 as being highly responsive to the Fe regime at the post-transcriptional level in the tips of cucumber (Cucumis sativus) roots.	Iron	118-120	ubiquitin-conjugating enzyme E2 35-like	Cucumis sativus	78-83
20113438-4	2010	Ectopic expression of the cucumber UBC13 gene in Arabidopsis thaliana led to a more pronounced and Fe-responsive formation of branched root hairs, a key response of Arabidopsis roots to Fe deficiency.	Iron	99-101	ubiquitin-conjugating enzyme E2 35-like	Cucumis sativus	35-40
20096706-4	2010	The association constant for the binding of diferric transferrin (Tf) to TfR2alpha is 5.6x10(6) M(-)(1), which is about 50 times lower than that for the binding of Tf to TfR1, with correspondingly reduced rates of iron uptake.	Iron	214-218	transferrin receptor protein 2	Cricetulus griseus	73-77
20096706-4	2010	The association constant for the binding of diferric transferrin (Tf) to TfR2alpha is 5.6x10(6) M(-)(1), which is about 50 times lower than that for the binding of Tf to TfR1, with correspondingly reduced rates of iron uptake.	Iron	214-218	transferrin receptor protein 1	Cricetulus griseus	170-174
20182009-5	2010	The morphology and structural properties of all these iron-based 1D nanostructures were fully characterized by SEM, TEM, XRD and Raman spectroscopy.	Iron	54-58	MFT2	Homo sapiens	116-119
20152801-9	2010	We conclude that Ca2+ is a low-affinity noncompetitive inhibitor--but not a transported substrate--of DMT1, explaining in part the effect of high dietary calcium on iron bioavailability.	Iron	165-169	carbonic anhydrase 2	Homo sapiens	17-20
20042601-0	2010	Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.	Iron	91-103	lysine demethylase 3A	Homo sapiens	40-46
20042601-4	2010	We find that, with iron, the 50% inhibitory concentrations of nickel (IC(50) [Ni(II)]) are 25 microm for JMJD1A and 7.5 microm for ABH2.	Iron	19-23	lysine demethylase 3A	Homo sapiens	105-111
20042601-5	2010	Without iron, JMJD1A is 10 times more sensitive to nickel inhibition with an IC(50) [Ni(II)] of 2.5 microm, and approximately one molecule of Ni(II) inhibits one molecule of JMJD1A, suggesting that nickel causes inhibition by replacing the iron.	Iron	240-244	lysine demethylase 3A	Homo sapiens	14-20
20019163-1	2010	Hephaestin (Hp) is a membrane protein with ferroxidase activity that converts Fe(II) to Fe(III) during the absorption of nutritional iron in the gut.	Iron	133-137	hephaestin	Homo sapiens	0-10
19861159-10	2010	NO dependent HIF-1alpha accumulation under normoxia was due to direct inhibition of PHDs and FIH-1 most likely by competitive binding of NO to the ferrous iron in the catalytically active center of the enzymes.	Iron	155-159	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	93-98
20065947-0	2010	Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma.	Iron	50-54	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	23-32
20065947-11	2010	These results not only show two distinct molecular pathways for iron-induced peritoneal mesothelioma, but also support the hypothesis that oxidative stress by iron overload is a major cause of CDKN2A/2B homozygous deletion.	Iron	159-163	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	193-199
20121272-12	2010	The increase of n(s)(BSA) by an increase in X(Fe) was explained by elongation of mean particle length along with the production of surface hydroxo ions, such as Fe(OH)2+ or Fe(OH)2+, to induce the hydrogen bond between the Fe(III)-substituted Hap surface and BSA molecules, though the number of original C sites established by Ca(II) atoms was reduced.	Iron	46-48	carbonic anhydrase 2	Homo sapiens	327-333
19969068-2	2010	Cultured rat cardiomyocytes incubated with 20 microM iron (added as FeCl(3)-Na nitrilotriacetate, Fe-NTA) displayed hypertrophy features that included increased protein synthesis and cell size, plus realignment of F-actin filaments along with sarcomeres and activation of the atrial natriuretic factor gene promoter.	Iron	53-57	natriuretic peptide A	Rattus norvegicus	276-301
20010695-3	2010	NAF-1 contains a two iron-two sulphur coordinating domain within its cytosolic region, which is necessary, but not sufficient for interaction with BCL-2.	Iron	21-25	CDGSH iron sulfur domain 2	Homo sapiens	0-5
20018808-6	2010	As determined by quantitative real-time PCR, hepatic expression of hepcidin (HAMP) in pigs given the high-Fe diet was 6.25-fold that of control pigs.	Iron	106-108	hepcidin antimicrobial peptide	Sus scrofa	67-75
20014790-4	2010	A crystal structure of inhibitor 3 coordinated to heme iron was obtained, representing, to our knowledge, the first crystal structure of a thioether inhibitor complexed to any heme enzyme.	Iron	55-59	protein phosphatase 1 regulatory inhibitor subunit 11	Homo sapiens	23-34
19923220-1	2010	Mutations in the coding sequence of the ferritin light chain (FTL) gene cause a neurodegenerative disease known as neuroferritinopathy or hereditary ferritinopathy, which is characterized by the presence of intracellular inclusion bodies containing the mutant FTL polypeptide and by abnormal accumulation of iron in the brain.	Iron	308-312	ferritin light chain	Homo sapiens	40-60
19923220-1	2010	Mutations in the coding sequence of the ferritin light chain (FTL) gene cause a neurodegenerative disease known as neuroferritinopathy or hereditary ferritinopathy, which is characterized by the presence of intracellular inclusion bodies containing the mutant FTL polypeptide and by abnormal accumulation of iron in the brain.	Iron	308-312	ferritin light chain	Homo sapiens	62-65
19923220-5	2010	Functional studies underscored the importance of the mutant C-terminal sequence in iron-induced precipitation and revealed iron mishandling by soluble mutant FTL homopolymers in that only wild type incorporated iron when in direct competition in solution with mutant ferritin.	Iron	123-127	ferritin light chain	Homo sapiens	158-161
19923220-5	2010	Functional studies underscored the importance of the mutant C-terminal sequence in iron-induced precipitation and revealed iron mishandling by soluble mutant FTL homopolymers in that only wild type incorporated iron when in direct competition in solution with mutant ferritin.	Iron	123-127	ferritin light chain	Homo sapiens	158-161
20000481-2	2010	In the M = 2S + 1 = 13 (S is the total spin) ground state (GS) of Fe(6)-(C(6)H(6))(3) each benzene is bonded with one Fe atom, forming eta(6) coordinations with C-Fe contacts of 2.12-2.17 A; though the Fe(6) cluster structure is preserved, it presents more distortion than in bare Fe(6).	Iron	66-68	spindlin 1	Homo sapiens	39-43
20208373-0	2010	Rapid regulation of intestinal divalent metal (cation) transporter 1 (DMT1/DCT1) and ferritin mRNA expression in response to excess iron loading in iron-deficient rats.	Iron	132-136	RoBo-1	Rattus norvegicus	70-74
20208373-0	2010	Rapid regulation of intestinal divalent metal (cation) transporter 1 (DMT1/DCT1) and ferritin mRNA expression in response to excess iron loading in iron-deficient rats.	Iron	148-152	RoBo-1	Rattus norvegicus	70-74
20208373-1	2010	We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption.	Iron	36-40	RoBo-1	Rattus norvegicus	71-99
20208373-1	2010	We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption.	Iron	36-40	RoBo-1	Rattus norvegicus	101-105
20208373-1	2010	We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption.	Iron	128-132	RoBo-1	Rattus norvegicus	71-99
20208373-1	2010	We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption.	Iron	128-132	RoBo-1	Rattus norvegicus	101-105
20208373-1	2010	We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption.	Iron	128-132	RoBo-1	Rattus norvegicus	71-99
20208373-1	2010	We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption.	Iron	128-132	RoBo-1	Rattus norvegicus	101-105
20208373-2	2010	DMT1 mRNA was down-regulated and Ft mRNA was up-regulated 2 h after administering the iron.	Iron	86-90	RoBo-1	Rattus norvegicus	0-4
19786029-0	2010	Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	107-115
19786029-2	2010	METHODS: BMP and hepcidin expression upon iron sensing were analyzed in vivo in BMP6(-/-) and BMP6(+/+) mice and ex vivo in tissue and in vitro in cells of the liver and the small intestine.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	17-25
19786029-8	2010	Furthermore, iron-supplemented diet induced a compensatory up-regulation of BMP2, BMP4, and BMP9 in the small intestine of BMP6(-/-) mice that was apparently not sufficient to assure iron homeostasis.	Iron	13-17	growth differentiation factor 2	Mus musculus	92-96
21244816-0	2010	Development of low-cost technology for the removal of iron and manganese from ground water in siwa oasis.	Iron	54-58	cAMP responsive element binding protein 3 like 1	Homo sapiens	99-104
21244816-3	2010	Water samples collected from Siwa Oasis had relatively higher iron (Fe) and manganese (Mn) than the permissible limits specified in WHO Guidelines and Egyptian Standards for drinking water quality.	Iron	62-66	cAMP responsive element binding protein 3 like 1	Homo sapiens	34-39
21244816-5	2010	AIM: The study aimed at development of low-cost technology for the removal of iron and manganese from ground water in Siwa Oasis.	Iron	78-82	cAMP responsive element binding protein 3 like 1	Homo sapiens	123-128
20424477-1	2010	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) binds small, iron-carrying molecules - siderophores.	Iron	75-79	lipocalin 2	Homo sapiens	12-54
20424477-1	2010	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) binds small, iron-carrying molecules - siderophores.	Iron	75-79	lipocalin 2	Homo sapiens	56-60
19249912-1	2010	Hepcidin is a key regulator of iron homeostasis, while hemojuvelin is an important component of the hepcidin regulation pathway.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	0-8
19249912-8	2010	Phlebotomies reduced hepatic iron overload in Hjv-/- mice by 80 %.	Iron	29-33	hemojuvelin BMP co-receptor	Mus musculus	46-49
20055961-5	2010	Expression of AtIRT1, AtFRO2, AtFIT1 and AtFER1 was up-regulated by CO exposure in iron-deficient seedlings.	Iron	83-87	iron-regulated transporter 1	Arabidopsis thaliana	14-20
20041757-2	2010	We found that in response to exposure to iron ions, HRR contributed to cell survival in rodent cells and that HRR deficiency abrogated RAD51 focus formation.	Iron	41-45	RAD51 recombinase	Homo sapiens	135-140
20041757-5	2010	Human cells synchronized in S phase exhibited a more pronounced resistance to iron ions compared with cells in G(1) phase, and this increase in radioresistance was diminished by RAD51 knockdown.	Iron	78-82	RAD51 recombinase	Homo sapiens	178-183
19968319-8	2009	MoS(2) sheets adsorbed on a nascent iron substrate reduced friction further due to much larger Coulombic repulsive interactions.	Iron	36-40	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	0-3
19864422-5	2009	Here, we provide evidence for a role for a human homologue of IscA, named IscA1, in iron-sulfur protein biogenesis.	Iron	84-88	iron-sulfur cluster assembly 1	Homo sapiens	74-79
19864422-6	2009	We observe that small interfering RNA knockdown of IscA1 in HeLa cells leads to decreased activity of two mitochondrial iron-sulfur enzymes, succinate dehydrogenase and mitochondrial aconitase, as well as a cytosolic iron-sulfur enzyme, cytosolic aconitase.	Iron	120-124	iron-sulfur cluster assembly 1	Homo sapiens	51-56
19864422-9	2009	We therefore propose that human IscA1 plays an important role in both mitochondrial and cytosolic iron-sulfur cluster biogenesis, and a notable component of the latter is the interaction between IscA1 and IOP1.	Iron	98-102	iron-sulfur cluster assembly 1	Homo sapiens	32-37
19797250-6	2009	We have used synthetic antisense morpholinos to inhibit the translation of huntingtin mRNA during early zebrafish development and have previously reported the effects of huntingtin reduction on iron transport and homeostasis.	Iron	194-198	huntingtin	Danio rerio	170-180
21836202-0	2009	Molecular dynamics simulations of hcp/fcc nucleation and growth in bcc iron driven by uniaxial compression.	Iron	71-75	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	34-37
19963161-3	2009	Our hypothesis was that inulin-type fructans (ITF), which are known to affect mineral absorption, could increase Ca and Fe bioavailability in Ca- and Fe-deficient rats.	Iron	120-122	trefoil factor 3	Rattus norvegicus	24-50
19963161-3	2009	Our hypothesis was that inulin-type fructans (ITF), which are known to affect mineral absorption, could increase Ca and Fe bioavailability in Ca- and Fe-deficient rats.	Iron	150-152	trefoil factor 3	Rattus norvegicus	24-50
19963161-9	2009	In Ca-deficient rats, ITF increased liver (Fe and Zn) and tibia (Zn) mineral levels but impaired tibia Mg, yield load, and resilience.	Iron	43-45	trefoil factor 3	Rattus norvegicus	22-25
19699718-0	2009	Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson"s disease.	Iron	116-120	ferritin heavy polypeptide 1	Mus musculus	22-32
19787796-0	2009	HFE, SLC40A1, HAMP, HJV, TFR2, and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants.	Iron	117-121	ferritin light chain	Homo sapiens	35-38
19751239-0	2009	Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	19-27
19751239-0	2009	Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	42-46
19751239-1	2009	Hepcidin, the master regulator of enteric iron absorption, is controlled by the opposing effects of pathways activated in response to iron excess or iron attenuation.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	0-8
19751239-1	2009	Hepcidin, the master regulator of enteric iron absorption, is controlled by the opposing effects of pathways activated in response to iron excess or iron attenuation.	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	0-8
19751239-1	2009	Hepcidin, the master regulator of enteric iron absorption, is controlled by the opposing effects of pathways activated in response to iron excess or iron attenuation.	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	0-8
19751239-2	2009	Iron excess is regulated through a pathway involving the cell surface receptor hemojuvelin (HFE2) that stimulates expression of the hepcidin encoding gene (HAMP).	Iron	0-4	hemojuvelin BMP co-receptor	Mus musculus	79-90
19751239-2	2009	Iron excess is regulated through a pathway involving the cell surface receptor hemojuvelin (HFE2) that stimulates expression of the hepcidin encoding gene (HAMP).	Iron	0-4	hemojuvelin BMP co-receptor	Mus musculus	92-96
19751239-2	2009	Iron excess is regulated through a pathway involving the cell surface receptor hemojuvelin (HFE2) that stimulates expression of the hepcidin encoding gene (HAMP).	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	132-140
19751239-2	2009	Iron excess is regulated through a pathway involving the cell surface receptor hemojuvelin (HFE2) that stimulates expression of the hepcidin encoding gene (HAMP).	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	156-160
19751239-3	2009	Iron attenuation is countered through a pathway involving the hepatocyte-specific plasma membrane protease matriptase-2 encoded by TMPRSS6, leading to suppression of HAMP expression.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	166-170
19751239-7	2009	Mice lacking functional matriptase-2 and hemojuvelin exhibited low Hamp (Hamp1) expression, high serum and liver iron, and high transferrin saturation.	Iron	113-117	hemojuvelin BMP co-receptor	Mus musculus	41-52
19713312-4	2009	We observed elevated serum Ca(2+) and fractional excretion of Ca(2+) (FE(Ca)) in klotho(-/-) mice.	Iron	70-72	klotho	Mus musculus	81-87
19549696-2	2009	METHODS: The aim of the present study was to evaluate serum levels of neutrophil gelatinase-associated lipocalin (NGAL), a small siderophore-binding protein, in a cohort of 56 chronic HD patients in order to determine its possible relationships with iron status.	Iron	250-254	lipocalin 2	Homo sapiens	70-112
19549696-2	2009	METHODS: The aim of the present study was to evaluate serum levels of neutrophil gelatinase-associated lipocalin (NGAL), a small siderophore-binding protein, in a cohort of 56 chronic HD patients in order to determine its possible relationships with iron status.	Iron	250-254	lipocalin 2	Homo sapiens	114-118
19549696-4	2009	iron administration significantly increased NGAL values from baseline.	Iron	0-4	lipocalin 2	Homo sapiens	44-48
19549696-7	2009	CONCLUSIONS: The findings demonstrated that HD patients have altered NGAL values probably because this protein is involved in the maintenance of iron equilibrium.	Iron	145-149	lipocalin 2	Homo sapiens	69-73
19549696-8	2009	Finally, NGAL might be proposed as a new tool in the assessment of iron deficiency and in the management of iron therapy for HD patients.	Iron	67-71	lipocalin 2	Homo sapiens	9-13
19935988-1	2009	There may be a relationship between proton pump inhibitors (PPIs) and iron absorption.	Iron	70-74	ATPase H+/K+ transporting subunit alpha	Homo sapiens	36-47
19726572-6	2009	In the vit1-1 mutant, in which the Fe pattern is disturbed, Fe is stored in vacuoles of cortex cells of the hypocotyl/radicle axis and in a single subepidermal cell layer in the cotyledons.	Iron	35-37	vacuolar iron transporter 1	Arabidopsis thaliana	7-13
19726572-6	2009	In the vit1-1 mutant, in which the Fe pattern is disturbed, Fe is stored in vacuoles of cortex cells of the hypocotyl/radicle axis and in a single subepidermal cell layer in the cotyledons.	Iron	60-62	vacuolar iron transporter 1	Arabidopsis thaliana	7-13
19726572-7	2009	During the early stages of embryo development, Fe is evenly distributed in the cells of both wild-type and vit1-1 mutants.	Iron	47-49	vacuolar iron transporter 1	Arabidopsis thaliana	107-113
19726572-8	2009	Fe eventually accumulates in endodermal cells as the vascular system develops, a process that is impaired in vit1-1.	Iron	0-2	vacuolar iron transporter 1	Arabidopsis thaliana	109-115
19646959-6	2009	Hypoxia (1% O(2)) and the iron chelator deferoxamine (DFX), a hypoxia mimetic, increased the levels of CXCR4 mRNA in A172 and T98G cells, and treatment with IFNgamma inhibited the expression of CXCR4 mRNA.	Iron	26-30	C-X-C motif chemokine receptor 4	Homo sapiens	103-108
19646959-6	2009	Hypoxia (1% O(2)) and the iron chelator deferoxamine (DFX), a hypoxia mimetic, increased the levels of CXCR4 mRNA in A172 and T98G cells, and treatment with IFNgamma inhibited the expression of CXCR4 mRNA.	Iron	26-30	C-X-C motif chemokine receptor 4	Homo sapiens	194-199
19805291-7	2009	In undifferentiated MEL cells, cotransfected Abcb10 specifically interacts with Mfrn1 to enhance its protein stability and promote Mfrn1-dependent mitochondrial iron importation.	Iron	161-165	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	45-51
19805308-3	2009	Using cardiac tissues, we demonstrate that frataxin deficiency leads to down-regulation of key molecules involved in 3 mitochondrial utilization pathways: iron-sulfur cluster (ISC) synthesis (iron-sulfur cluster scaffold protein1/2 and the cysteine desulferase Nfs1), mitochondrial iron storage (mitochondrial ferritin), and heme synthesis (5-aminolevulinate dehydratase, coproporphyrinogen oxidase, hydroxymethylbilane synthase, uroporphyrinogen III synthase, and ferrochelatase).	Iron	155-159	frataxin	Mus musculus	43-51
19805308-3	2009	Using cardiac tissues, we demonstrate that frataxin deficiency leads to down-regulation of key molecules involved in 3 mitochondrial utilization pathways: iron-sulfur cluster (ISC) synthesis (iron-sulfur cluster scaffold protein1/2 and the cysteine desulferase Nfs1), mitochondrial iron storage (mitochondrial ferritin), and heme synthesis (5-aminolevulinate dehydratase, coproporphyrinogen oxidase, hydroxymethylbilane synthase, uroporphyrinogen III synthase, and ferrochelatase).	Iron	192-196	frataxin	Mus musculus	43-51
19682722-7	2009	Because of the high alkalinity generated from the alkaline coal ash, even a small increase in the Fe concentration (0.66mgL(-1) on average) could cause siderite precipitation.	Iron	98-100	LLGL scribble cell polarity complex component 1	Homo sapiens	120-126
19764221-5	2009	The dominant speciation of the immobilized iron and arsenic was Fe(III) and As(V) in SF1, compared with Fe(II) and As(III) in SF2.	Iron	43-47	splicing factor 1	Homo sapiens	85-88
19581449-0	2009	KlAft, the Kluyveromyces lactis ortholog of Aft1 and Aft2, mediates activation of iron-responsive transcription through the PuCACCC Aft-type sequence.	Iron	82-86	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	44-48
19581449-5	2009	We identify an ortholog of AFT1/AFT2, designated KlAFT, whose deletion leads to the inability to grow under iron limitation.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	27-31
19581449-6	2009	We show with quantitative real-time PCR analysis that KlAft activates the transcription of all homologs of the Aft1-target genes involved in the iron transport at the cell surface in response to iron limitation.	Iron	145-149	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	111-115
19581449-6	2009	We show with quantitative real-time PCR analysis that KlAft activates the transcription of all homologs of the Aft1-target genes involved in the iron transport at the cell surface in response to iron limitation.	Iron	195-199	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	111-115
19533074-2	2009	In mammals, iron homeostasis is regulated systemically by the iron-hormone hepcidin, an acute-phase protein secreted by the liver which inhibits iron absorption and recycling.	Iron	12-16	hepcidin antimicrobial peptide	Mus musculus	75-83
19533074-2	2009	In mammals, iron homeostasis is regulated systemically by the iron-hormone hepcidin, an acute-phase protein secreted by the liver which inhibits iron absorption and recycling.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	75-83
19533074-2	2009	In mammals, iron homeostasis is regulated systemically by the iron-hormone hepcidin, an acute-phase protein secreted by the liver which inhibits iron absorption and recycling.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	75-83
19533074-9	2009	Importantly, Irp1 (-/-) and Irp2 (-/-) animals, respectively, display quantitatively similar hepcidin mRNA induction and the appropriate reduction of the serum iron values.	Iron	160-164	aconitase 1	Mus musculus	13-17
19533074-9	2009	Importantly, Irp1 (-/-) and Irp2 (-/-) animals, respectively, display quantitatively similar hepcidin mRNA induction and the appropriate reduction of the serum iron values.	Iron	160-164	iron responsive element binding protein 2	Mus musculus	28-32
19587376-1	2009	Hepcidin is the major regulator of systemic iron homeostasis in mammals.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	0-8
19587376-3	2009	We measured serum levels of bioactive hepcidin and its effects on serum iron levels in mice infected with Borrelia burgdorferi.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	38-46
19703283-2	2009	FRDA, the most common recessive ataxia, results from a generalized deficiency of mitochondrial and cytosolic iron-sulfur cluster (ISC) proteins activity, due to a partial loss of frataxin function, a mitochondrial protein proposed to function as an iron-chaperone for ISC biosynthesis.	Iron	109-113	frataxin	Mus musculus	0-4
19561359-7	2009	In fact, we observed a requirement for the Isu proteins in iron inactivation of yeast Sod2p.	Iron	59-63	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	86-91
19561359-8	2009	Sod2p activity was restored in mtm1 and grx5 mutants by depleting cells of Isu proteins or using a dominant negative Isu1p predicted to stabilize iron binding to Isu1p.	Iron	146-150	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	0-5
19561359-8	2009	Sod2p activity was restored in mtm1 and grx5 mutants by depleting cells of Isu proteins or using a dominant negative Isu1p predicted to stabilize iron binding to Isu1p.	Iron	146-150	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	117-122
19561359-8	2009	Sod2p activity was restored in mtm1 and grx5 mutants by depleting cells of Isu proteins or using a dominant negative Isu1p predicted to stabilize iron binding to Isu1p.	Iron	146-150	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	162-167
19561359-9	2009	In all cases where disruptions in iron homeostasis inactivated Sod2p, we observed an increase in mitochondrial Isu proteins.	Iron	34-38	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	63-68
19561359-10	2009	These studies indicate that the Isu proteins and the iron-sulfur pathway can donate iron to Sod2p.	Iron	53-57	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	92-97
19561359-10	2009	These studies indicate that the Isu proteins and the iron-sulfur pathway can donate iron to Sod2p.	Iron	84-88	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	92-97
19679815-0	2009	ER stress controls iron metabolism through induction of hepcidin.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	56-64
19679815-1	2009	Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	0-8
19679815-3	2009	Inflammation and iron are known extracellular stimuli for hepcidin expression.	Iron	17-21	hepcidin antimicrobial peptide	Mus musculus	58-66
19792665-2	2009	By combining real-space imaging of scanning tunneling microscopy and spectroscopy (STM+STS) with momentum-space quantitative low-energy electron diffraction (LEED), we have identified the surface plane of cleaved BaFe2As2 crystals as the As terminated Fe-As layer-the plane where superconductivity occurs.	Iron	215-217	sulfotransferase family 1A member 3	Homo sapiens	83-86
19792665-4	2009	It is surprising that STM images the different Fe-As orbitals associated with the orthorhombic structure, but not the As atoms in the surface plane.	Iron	47-49	sulfotransferase family 1A member 3	Homo sapiens	22-25
19538181-6	2009	Mutant Zrc1 that gained iron transport activity could protect cells with a deletion in the vacuolar iron transporter (CCC1) from high iron toxicity.	Iron	24-28	Ccc1p	Saccharomyces cerevisiae S288C	118-122
19538181-6	2009	Mutant Zrc1 that gained iron transport activity could protect cells with a deletion in the vacuolar iron transporter (CCC1) from high iron toxicity.	Iron	100-104	Ccc1p	Saccharomyces cerevisiae S288C	118-122
19545236-2	2009	In Arabidopsis, AtNRAMP3 and AtNRAMP4 play a key role in iron nutrition of the germinating plantlet by remobilizing vacuolar iron stores.	Iron	57-61	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	16-24
19545236-2	2009	In Arabidopsis, AtNRAMP3 and AtNRAMP4 play a key role in iron nutrition of the germinating plantlet by remobilizing vacuolar iron stores.	Iron	57-61	natural resistance associated macrophage protein 4	Arabidopsis thaliana	29-37
19545236-2	2009	In Arabidopsis, AtNRAMP3 and AtNRAMP4 play a key role in iron nutrition of the germinating plantlet by remobilizing vacuolar iron stores.	Iron	125-129	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	16-24
19545236-2	2009	In Arabidopsis, AtNRAMP3 and AtNRAMP4 play a key role in iron nutrition of the germinating plantlet by remobilizing vacuolar iron stores.	Iron	125-129	natural resistance associated macrophage protein 4	Arabidopsis thaliana	29-37
19574425-7	2009	These markers included high levels of scavenger receptors, CD163 and CD206, which are involved in both the scavenging of hemoglobin with iron transfer into macrophages and the silent clearance of inflammatory molecules.	Iron	137-141	mannose receptor, C type 1	Mus musculus	69-74
19351705-2	2009	In previous studies, we have identified FOX1 and ATX1 FEREs (Fe deficiency-responsive elements) as important regulation components of iron response in this organism.	Iron	134-138	antioxidant 1 copper chaperone	Homo sapiens	49-53
19351705-7	2009	Sequence comparison of FeaFeRE1 and FeaFeRE2 reveals a core sequence of TGGCA, which had been found in our previously reported Fe-deficiency-inducible gene ATX1.	Iron	23-25	antioxidant 1 copper chaperone	Homo sapiens	156-160
19467564-11	2009	The cathodic production of H2 by anaerobic corrosion of Fe probably sustained a higher level of SRB activity in the FeOC column.	Iron	56-58	chaperonin containing TCP1 subunit 4	Homo sapiens	96-99
19453295-5	2009	Overexpression of dmfrn in the Drosophila l(2)mbn cell line (mbn-dmfrn) resulted in decreased binding between IRP-1A (iron regulatory protein 1A) and stem-loop RNA structures referred to as IREs (iron responsive elements).	Iron	118-122	Iron regulatory protein 1A	Drosophila melanogaster	110-116
19453295-7	2009	In contrast, iron loading results in decreased IRP-1A-IRE binding, but increased cellular iron content, in experimental mbn-dmfrn and control cell lines.	Iron	13-17	Iron regulatory protein 1A	Drosophila melanogaster	47-53
19453295-7	2009	In contrast, iron loading results in decreased IRP-1A-IRE binding, but increased cellular iron content, in experimental mbn-dmfrn and control cell lines.	Iron	13-17	ire	Drosophila melanogaster	54-57
19414861-1	2009	In thalassemia and other iron loading anemias, ineffective erythropoiesis and erythroid signaling molecules are thought to cause inappropriate suppression of a small peptide produced by hepatocytes named hepcidin.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	204-212
19401454-3	2009	The present study demonstrated that LDL oxidized by copper, iron, or 3-morpholinosydnonimine increased the expression of NADPH oxidase (NOX) 2, PAI-1, and heat shock factor-1 (HSF1) in human umbilical vein EC or coronary artery EC compared with LDL or vehicle.	Iron	60-64	cytochrome b-245 beta chain	Homo sapiens	121-142
19380472-10	2009	GAPDH was detected on the surface of trichomonads and was upregulated in synthesis and surface expression by iron.	Iron	109-113	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	0-5
19496564-9	2009	Given the fact that the origin of this prepeak corresponds to the transition of the O 1s electron to the unoccupied state of O 2p hybridized with Fe 3d, a weak pre-edge peak indicates a combination of the following four factors: a higher degree of occupancy of the Fe 3d orbital; a longer Fe-O bond length; a decreased covalency of the Fe-O bond; and a measure of cation vacancies.	Iron	146-148	immunoglobulin kappa variable 1D-39	Homo sapiens	125-129
19496564-9	2009	Given the fact that the origin of this prepeak corresponds to the transition of the O 1s electron to the unoccupied state of O 2p hybridized with Fe 3d, a weak pre-edge peak indicates a combination of the following four factors: a higher degree of occupancy of the Fe 3d orbital; a longer Fe-O bond length; a decreased covalency of the Fe-O bond; and a measure of cation vacancies.	Iron	265-267	immunoglobulin kappa variable 1D-39	Homo sapiens	125-129
19452451-0	2009	Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells.	Iron	64-68	hephaestin	Homo sapiens	10-20
19452451-3	2009	However, iron egress from the basolateral side of enterocytes converges on a single export pathway requiring the iron transporter, ferroportin1, and hephaestin, a ferroxidase.	Iron	9-13	hephaestin	Homo sapiens	149-159
19452451-6	2009	Furthermore, the decrease in hephaestin levels correlates with a decrease of (55)Fe release from the basolateral side of Caco2 cells.	Iron	81-83	hephaestin	Homo sapiens	29-39
19916465-3	2009	The results show that the Nd2(Fe, Co)14B matrix phase in the alloy can be mechanically disproportionated by a two-stage reaction.	Iron	30-32	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	26-29
19916465-4	2009	Firstly, the Nd2(Fe, Co)14B matrix phase in the alloy is hydrogenated into Nd2(Fe, Co)14BH(x), until the value of x achieves about 2.9 when a full hydrogenation is achieved.	Iron	17-19	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	13-16
19916465-4	2009	Firstly, the Nd2(Fe, Co)14B matrix phase in the alloy is hydrogenated into Nd2(Fe, Co)14BH(x), until the value of x achieves about 2.9 when a full hydrogenation is achieved.	Iron	17-19	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	75-78
19916465-4	2009	Firstly, the Nd2(Fe, Co)14B matrix phase in the alloy is hydrogenated into Nd2(Fe, Co)14BH(x), until the value of x achieves about 2.9 when a full hydrogenation is achieved.	Iron	79-81	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	13-16
19916465-4	2009	Firstly, the Nd2(Fe, Co)14B matrix phase in the alloy is hydrogenated into Nd2(Fe, Co)14BH(x), until the value of x achieves about 2.9 when a full hydrogenation is achieved.	Iron	79-81	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	75-78
19371723-7	2009	Inter-strain variation in hepcidin expression correlated with established phenotypic differences in iron loading in these mice.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	26-34
19371723-8	2009	As hepcidin is critically required for iron metabolism, we posit that variation in its expression may be a quantitative trait which determines differences in iron handling within and between mouse strains, and that this may also apply to humans.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	3-11
19371723-8	2009	As hepcidin is critically required for iron metabolism, we posit that variation in its expression may be a quantitative trait which determines differences in iron handling within and between mouse strains, and that this may also apply to humans.	Iron	158-162	hepcidin antimicrobial peptide	Mus musculus	3-11
21693955-1	2009	By using molecular dynamics simulations, we have successfully simulated the bcc [Formula: see text] hcp structural transition in single-crystal iron under isothermal compression along the [001] direction.	Iron	144-148	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	100-103
19028100-0	2009	Design, synthesis and herbicidal activity of new iron chelating motifs for HPPD-inhibitors.	Iron	49-53	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	75-79
19028100-3	2009	The activity of all commercialized HPPD-inhibitors is based on a chelating functionality, which binds to the redoxactive iron center in the enzyme.	Iron	121-125	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	35-39
19380872-0	2009	Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	0-8
19380872-1	2009	Hepcidin is a major regulator of iron metabolism.	Iron	33-37	hepcidin antimicrobial peptide	Mus musculus	0-8
19380872-10	2009	The demonstration that alpha2-M is the hepcidin transporter could lead to better understanding of hepcidin physiology, methods for its sensitive measurement and the development of novel drugs for the treatment of iron-related diseases.	Iron	213-217	hepcidin antimicrobial peptide	Mus musculus	39-47
19385603-0	2009	Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1.	Iron	67-71	colicin Ia	Escherichia coli	95-98
19385603-1	2009	Iron-sulfur (Fe/S) protein maturation in the eukaryotic cytosol and nucleus requires conserved components of the essential CIA machinery.	Iron	13-15	colicin Ia	Escherichia coli	123-126
19449457-2	2009	Here we show altered iron homeostasis in mouse models of both GM1 and GM2 gangliosidoses, which are characterized by progressive depletion of iron in brain tissue.	Iron	21-25	coenzyme Q10A	Mus musculus	62-65
19449457-4	2009	We found that key regulators of iron homeostasis, hepcidin and IL-6, were increased in gangliosidoses mice.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	50-58
19449457-5	2009	In the brain, the principal iron transport and delivery protein transferrin was reduced, accompanied by a progressive inability of the brain to acquire iron from the circulation.	Iron	28-32	transferrin	Mus musculus	64-75
19234060-1	2009	Mutations in hemojuvelin (HJV) cause severe juvenile hemochromatosis, characterized by iron loading of the heart, liver, and pancreas.	Iron	87-91	hemojuvelin BMP co-receptor	Mus musculus	13-24
19234060-1	2009	Mutations in hemojuvelin (HJV) cause severe juvenile hemochromatosis, characterized by iron loading of the heart, liver, and pancreas.	Iron	87-91	hemojuvelin BMP co-receptor	Mus musculus	26-29
19234060-2	2009	Knockout (KO) mice lacking HJV (Hjv-/-) spontaneously load with dietary iron and, therefore, present a model for hereditary hemochromatosis (HH).	Iron	72-76	hemojuvelin BMP co-receptor	Mus musculus	27-30
19234060-11	2009	In Hjv-/- mice, liver and heart iron burden was effectively reduced with deferasirox 100 mg/kg (P&lt;0.05).	Iron	32-36	hemojuvelin BMP co-receptor	Mus musculus	3-6
19264360-7	2009	Considering protein tyrosine nitration, protein oxidation and lipid oxidation as overall oxidative damage, these results indicated that methemoglobin is more toxic than hemin and ferric citrate, the degradation procedure of heme containing macromolecules, e.g. hemoglobin to hemin and finally to low molecular weight bounded iron, is step by step detoxification.	Iron	325-329	hemoglobin subunit gamma 2	Homo sapiens	136-149
19519778-3	2009	Compared with wild-type mice, brain extracts from Tg (FTL-Tg) mice showed an increase in the cytoplasmic levels of both FTL and ferritin heavy chain polypeptides, a decrease in the protein and mRNA levels of transferrin receptor-1, and a significant increase in iron levels.	Iron	262-266	ferritin light polypeptide 1	Mus musculus	54-57
19519778-5	2009	However, gene expression analysis of iron management proteins in the liver of Tg mice indicates that the FTL-Tg mouse liver is iron deficient.	Iron	37-41	ferritin light polypeptide 1	Mus musculus	105-108
19519778-5	2009	However, gene expression analysis of iron management proteins in the liver of Tg mice indicates that the FTL-Tg mouse liver is iron deficient.	Iron	127-131	ferritin light polypeptide 1	Mus musculus	105-108
19308044-5	2009	Furthermore, we observed that the NGAL-overexpressing cells tolerated increased iron levels in the culture environment, whereas the NGAL-underexpressing cells showed significant cell death after prolonged incubation in high-iron condition.	Iron	110-114	lipocalin 2	Homo sapiens	34-38
19321419-5	2009	Furthermore, hepatocyte iron content and hepcidin mRNA levels were dramatically lower in KO mice, indicating that hepcidin levels can be regulated by low-hepatocyte iron stores despite increased transferrin saturation.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	114-122
19321419-5	2009	Furthermore, hepatocyte iron content and hepcidin mRNA levels were dramatically lower in KO mice, indicating that hepcidin levels can be regulated by low-hepatocyte iron stores despite increased transferrin saturation.	Iron	165-169	hepcidin antimicrobial peptide	Mus musculus	114-122
19168612-0	2009	Roles of Agrobacterium tumefaciens RirA in iron regulation, oxidative stress response, and virulence.	Iron	43-47	rirA	Agrobacterium tumefaciens	35-39
19168612-1	2009	The analysis of genetics and physiological functions of Agrobacterium tumefaciens RirA (rhizobial iron regulator) has shown that it is a transcription regulator and a repressor of iron uptake systems.	Iron	98-102	rirA	Agrobacterium tumefaciens	82-86
19168612-2	2009	The rirA mutant strain (NTLrirA) overproduced siderophores and exhibited a highly constitutive expression of genes involved in iron uptake (fhuA, irp6A, and fbpA) compared to that of the wild-type strain (NTL4).	Iron	127-131	rirA	Agrobacterium tumefaciens	4-8
19460301-0	2009	Overexpression of the yeast frataxin homolog (Yfh1): contrasting effects on iron-sulfur cluster assembly, heme synthesis and resistance to oxidative stress.	Iron	76-80	ferroxidase	Saccharomyces cerevisiae S288C	46-50
19460301-4	2009	Cells overexpressing YFH1 on a plasmid (2muYFH1; about 3500 molecules Yfh1/cell) took up more iron than wild-type cells and displayed defective [Fe-S] cluster assembly/stability in vivo.	Iron	94-98	ferroxidase	Saccharomyces cerevisiae S288C	21-25
19252486-1	2009	Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2).	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	130-138
19252486-1	2009	Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2).	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	140-144
19252486-1	2009	Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2).	Iron	31-35	hemojuvelin BMP co-receptor	Mus musculus	163-167
19252486-5	2009	In vivo, HJV.Fc or a neutralizing antibody to BMP6 inhibits hepcidin expression and increases serum iron, whereas DRAGON.Fc has no effect.	Iron	100-104	hemojuvelin BMP co-receptor	Mus musculus	9-12
19121106-6	2009	The susceptibility of the double nramp3 nramp4 mutant is associated with the reduced accumulation of reactive oxygen species and ferritin (AtFER1), an iron storage protein known to participate in A. thaliana defense.	Iron	151-155	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	33-39
19121106-6	2009	The susceptibility of the double nramp3 nramp4 mutant is associated with the reduced accumulation of reactive oxygen species and ferritin (AtFER1), an iron storage protein known to participate in A. thaliana defense.	Iron	151-155	natural resistance associated macrophage protein 4	Arabidopsis thaliana	40-46
19129187-2	2009	Here we show that the AddB subunit contains a novel class of nuclease domain distinguished by the presence of an iron-sulfur cluster.	Iron	113-117	adducin 2	Homo sapiens	22-26
19129187-3	2009	The cluster is coordinated by an unusual arrangement of cysteine residues that originate from both sides of the AddB nuclease, forming an "iron staple" that is required for the local structural integrity of this domain.	Iron	139-143	adducin 2	Homo sapiens	112-116
19120353-0	2009	Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency.	Iron	14-18	growth differentiation factor 15	Homo sapiens	38-43
19120353-2	2009	Growth differentiation factor 15 (GDF15) has been identified as a bone marrow-derived factor that abrogates hepcidin-mediated protection from iron overload under conditions of increased erythropoiesis.	Iron	142-146	growth differentiation factor 15	Homo sapiens	0-32
19120353-2	2009	Growth differentiation factor 15 (GDF15) has been identified as a bone marrow-derived factor that abrogates hepcidin-mediated protection from iron overload under conditions of increased erythropoiesis.	Iron	142-146	growth differentiation factor 15	Homo sapiens	34-39
19120353-7	2009	These results suggest that GDF15 contributes to low hepcidin expression and iron loading in PKD.	Iron	76-80	growth differentiation factor 15	Homo sapiens	27-32
19120353-7	2009	These results suggest that GDF15 contributes to low hepcidin expression and iron loading in PKD.	Iron	76-80	protein kinase D1	Homo sapiens	92-95
19152427-0	2009	Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?	Iron	7-11	lipocalin 2	Homo sapiens	18-29
19152427-1	2009	UNLABELLED: Under normal conditions, iron is taken up by the cells through the transferrin-mediated pathway.	Iron	37-41	transferrin	Mus musculus	79-90
19252502-6	2009	Owing to the heightened iron demand in osteoclast development, transferrin receptor 1 (TfR1) expression was induced post-transcriptionally via iron regulatory protein 2.	Iron	24-28	iron responsive element binding protein 2	Mus musculus	143-168
19283519-4	2009	The airborne Mn levels were significantly associated with Mn/Fe ratio (MIR) of erythrocytes (eMIR) (r = 0.77, p &lt; 0.01) and plasma (pMIR) (r = 0.70, p &lt; 0.01).	Iron	61-63	membrane associated ring-CH-type finger 8	Homo sapiens	71-74
19147412-2	2009	Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators of iron absorption.	Iron	88-92	cytochrome b reductase 1	Homo sapiens	0-21
19147412-2	2009	Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators of iron absorption.	Iron	88-92	cytochrome b reductase 1	Homo sapiens	23-28
19147412-4	2009	Hypoxia-inducible factor (HIF) signaling was induced in the intestine following acute iron deficiency in the duodenum, resulting in activation of DcytB and DMT1 expression and an increase in iron uptake.	Iron	86-90	cytochrome b reductase 1	Homo sapiens	146-151
19059700-4	2009	Our preliminary data demonstrates that Hbb(th1/th1) mice, a model of beta-thalassemia intermedia, have lower bone marrow iron levels while levels in the liver and spleen are increased; the later account for the increased systemic iron burden in beta-thalassemia intermedia.	Iron	121-125	hemoglobin beta chain complex	Mus musculus	39-42
19059700-4	2009	Our preliminary data demonstrates that Hbb(th1/th1) mice, a model of beta-thalassemia intermedia, have lower bone marrow iron levels while levels in the liver and spleen are increased; the later account for the increased systemic iron burden in beta-thalassemia intermedia.	Iron	230-234	hemoglobin beta chain complex	Mus musculus	39-42
19059700-5	2009	We hypothesized that exogenous iron would improve anemia in beta-thalassemia intermedia despite systemic iron overload and further suppress hepcidin secondary to progressive expansion of erythroid precursors.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	140-148
19059700-6	2009	MATERIALS AND METHODS: We investigate parameters involved in red cell production, precursor apoptosis, parenchymal iron distribution, and hepcidin expression in iron treated Hbb(th1/th1) mice.	Iron	161-165	hepcidin antimicrobial peptide	Mus musculus	138-146
19059700-6	2009	MATERIALS AND METHODS: We investigate parameters involved in red cell production, precursor apoptosis, parenchymal iron distribution, and hepcidin expression in iron treated Hbb(th1/th1) mice.	Iron	161-165	hemoglobin beta chain complex	Mus musculus	174-177
19059700-9	2009	CONCLUSIONS: These findings demonstrate for the first time that iron results in expansion of extramedullary erythropoiesis, which improves anemia and suggests that expansion of extramedullary erythropoiesis itself results in hepcidin suppression in beta-thalassemia intermedia.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	225-233
19075006-0	2009	Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2.	Iron	28-32	solute carrier family 25 member 37	Homo sapiens	73-85
19075006-0	2009	Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2.	Iron	28-32	solute carrier family 25 member 28	Homo sapiens	90-102
19075006-2	2009	Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes.	Iron	43-47	solute carrier family 25 member 37	Homo sapiens	0-12
19075006-3	2009	Here we show that mitoferrin 1 and mitoferrin 2 contribute to mitochondrial iron delivery in a variety of cells.	Iron	76-80	solute carrier family 25 member 37	Homo sapiens	18-30
19075006-3	2009	Here we show that mitoferrin 1 and mitoferrin 2 contribute to mitochondrial iron delivery in a variety of cells.	Iron	76-80	solute carrier family 25 member 28	Homo sapiens	35-47
19075006-4	2009	Reductions in mitoferrin 1 and/or mitoferrin 2 levels by RNA interference result in decreased mitochondrial iron accumulation, heme synthesis, and iron-sulfur cluster synthesis.	Iron	108-112	solute carrier family 25 member 37	Homo sapiens	14-26
19075006-4	2009	Reductions in mitoferrin 1 and/or mitoferrin 2 levels by RNA interference result in decreased mitochondrial iron accumulation, heme synthesis, and iron-sulfur cluster synthesis.	Iron	108-112	solute carrier family 25 member 28	Homo sapiens	34-46
19075006-4	2009	Reductions in mitoferrin 1 and/or mitoferrin 2 levels by RNA interference result in decreased mitochondrial iron accumulation, heme synthesis, and iron-sulfur cluster synthesis.	Iron	147-151	solute carrier family 25 member 37	Homo sapiens	14-26
19075006-4	2009	Reductions in mitoferrin 1 and/or mitoferrin 2 levels by RNA interference result in decreased mitochondrial iron accumulation, heme synthesis, and iron-sulfur cluster synthesis.	Iron	147-151	solute carrier family 25 member 28	Homo sapiens	34-46
19075006-9	2009	These results suggest that mitochondrial iron accumulation is tightly regulated and that controlling mitoferrin levels within the mitochondrial membrane provides a mechanism to regulate mitochondrial iron levels.	Iron	41-45	solute carrier family 25 member 37	Homo sapiens	101-111
19075006-9	2009	These results suggest that mitochondrial iron accumulation is tightly regulated and that controlling mitoferrin levels within the mitochondrial membrane provides a mechanism to regulate mitochondrial iron levels.	Iron	200-204	solute carrier family 25 member 37	Homo sapiens	101-111
19056464-4	2009	The presence of ferric iron (Fe(3+)), but not ferrous iron (Fe(2+)), was strongly increased in the substantia nigra (SN) as a result of chronic loading of MPTP, whereas the ferritin-heavy chain (F-H) was significantly decreased.	Iron	23-27	ferritin heavy polypeptide 1	Mus musculus	173-193
19037245-8	2009	Spic(-/-) mice show normal trapping of red blood cells in the spleen, but fail to phagocytose these red blood cells efficiently, and develop an iron overload localized selectively to splenic red pulp.	Iron	144-148	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	0-4
19037245-9	2009	Thus, Spi-C controls development of red pulp macrophages required for red blood cell recycling and iron homeostasis.	Iron	99-103	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	6-11
19960042-3	2009	Hp2-2 favors endocytosis of hemoglobin iron in monocytes/macrophages, resulting in partial iron retention and increased intracellular ferritin levels.	Iron	39-43	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	0-5
19960042-3	2009	Hp2-2 favors endocytosis of hemoglobin iron in monocytes/macrophages, resulting in partial iron retention and increased intracellular ferritin levels.	Iron	91-95	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	0-5
19960042-7	2009	We conclude that there is a cause-and-effect relationship between the Hp2-2 genotype and increased iron indices in p.C282Y homozygous patients.	Iron	99-103	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	70-75
19055468-1	2009	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL), an iron-transporting protein rapidly accumulating in the kidney tubules and urine after nephrotoxic and ischemic insults, has been put forward as an early, sensitive, non-invasive biomarker for acute kidney injury (AKI).	Iron	66-70	lipocalin 2	Homo sapiens	12-54
19055468-1	2009	BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL), an iron-transporting protein rapidly accumulating in the kidney tubules and urine after nephrotoxic and ischemic insults, has been put forward as an early, sensitive, non-invasive biomarker for acute kidney injury (AKI).	Iron	66-70	lipocalin 2	Homo sapiens	56-60
20001631-5	2009	Other mechanisms that may reduce the extrahepatic iron distribution in SCD include raised plasma hepcidin due to chronic inflammation, lower growth differentiation factor 15 (GDF15) levels because of less ineffective erythropoiesis (IE), and induction of heme oxygenase (HO1) by intravascular hemolysis.	Iron	50-54	growth differentiation factor 15	Homo sapiens	141-173
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	18-22	iron-regulated transporter 1	Arabidopsis thaliana	53-57
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	iron-regulated transporter 1	Arabidopsis thaliana	53-57
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	iron-regulated transporter 1	Arabidopsis thaliana	53-57
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	iron-regulated transporter 1	Arabidopsis thaliana	53-57
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Iron	117-121	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	26-32
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Iron	117-121	natural resistance associated macrophage protein 4	Arabidopsis thaliana	39-45
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Iron	123-125	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	26-32
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Iron	123-125	natural resistance associated macrophage protein 4	Arabidopsis thaliana	39-45
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Iron	190-192	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	26-32
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Iron	190-192	natural resistance associated macrophage protein 4	Arabidopsis thaliana	39-45
19955842-6	2009	In contrast, the ALA-mediated PpIX accumulation was increased by deferoxamine, an iron chelator, manganese and nitric oxide, which is contributed to PpIX metabolism by inhibiting ferrochelatase activity, generated by a nitric oxide-generating reagent NOC-18.	Iron	82-86	ferrochelatase	Homo sapiens	179-193
19801348-12	2009	Iron deficiency was also associated with reduced levels of thyroxine-binding prealbumin (TBPA) and albumin (p &lt; 0.05).	Iron	0-4	transthyretin	Homo sapiens	59-87
19801348-12	2009	Iron deficiency was also associated with reduced levels of thyroxine-binding prealbumin (TBPA) and albumin (p &lt; 0.05).	Iron	0-4	transthyretin	Homo sapiens	89-93
19801348-18	2009	The reduction in albumin and TBPA associated with the iron deficiency but in the absence of any sign of malnutrition (W/H &gt; 96%) or inflammatory risk (PINI &lt; 2) in either study group shows that iron may play a dominant role during protein synthesis.	Iron	54-58	transthyretin	Homo sapiens	29-33
19801348-18	2009	The reduction in albumin and TBPA associated with the iron deficiency but in the absence of any sign of malnutrition (W/H &gt; 96%) or inflammatory risk (PINI &lt; 2) in either study group shows that iron may play a dominant role during protein synthesis.	Iron	200-204	transthyretin	Homo sapiens	29-33
18824595-4	2008	In addition, GDF15 correlated significantly with several erythropoietic and iron parameters including Hepcidin-25, Ferritin, and Hepcidin-25/Ferritin ratios.	Iron	76-80	growth differentiation factor 15	Homo sapiens	13-18
18930916-3	2008	Deletion of CCC1, which encodes the vacuolar iron importer, results in high iron sensitivity due to increased cytosolic iron.	Iron	45-49	Ccc1p	Saccharomyces cerevisiae S288C	12-16
18930916-3	2008	Deletion of CCC1, which encodes the vacuolar iron importer, results in high iron sensitivity due to increased cytosolic iron.	Iron	76-80	Ccc1p	Saccharomyces cerevisiae S288C	12-16
18930916-3	2008	Deletion of CCC1, which encodes the vacuolar iron importer, results in high iron sensitivity due to increased cytosolic iron.	Iron	76-80	Ccc1p	Saccharomyces cerevisiae S288C	12-16
18999859-5	2008	The state population change leads to a constant spin-orbit ratio, which explains the linear dependence between spin and orbital momentum changes within 2 ps upon the arrival of a pump pulse in Fe.	Iron	193-195	spindlin 1	Homo sapiens	48-52
18999859-5	2008	The state population change leads to a constant spin-orbit ratio, which explains the linear dependence between spin and orbital momentum changes within 2 ps upon the arrival of a pump pulse in Fe.	Iron	193-195	spindlin 1	Homo sapiens	111-115
18582504-0	2008	The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets.	Iron	4-8	N-myc downstream regulated 1	Homo sapiens	42-48
19017117-6	2008	Gene chip and real-time polymerase chain reaction analyses indicated that the expression of two Fe-related genes encoding an iron transporter AtIRT1 and an iron storage protein ferritin AtFER1 might be negatively regulated by MxMYB1 as the expression levels of these genes were lower in MxMYB1 expressing transgenic Arabidopsis plants as compared with wild type plants under both Fe-normal and Fe-deficient conditions.	Iron	96-98	iron-regulated transporter 1	Arabidopsis thaliana	142-148
19017117-6	2008	Gene chip and real-time polymerase chain reaction analyses indicated that the expression of two Fe-related genes encoding an iron transporter AtIRT1 and an iron storage protein ferritin AtFER1 might be negatively regulated by MxMYB1 as the expression levels of these genes were lower in MxMYB1 expressing transgenic Arabidopsis plants as compared with wild type plants under both Fe-normal and Fe-deficient conditions.	Iron	125-129	iron-regulated transporter 1	Arabidopsis thaliana	142-148
19017117-6	2008	Gene chip and real-time polymerase chain reaction analyses indicated that the expression of two Fe-related genes encoding an iron transporter AtIRT1 and an iron storage protein ferritin AtFER1 might be negatively regulated by MxMYB1 as the expression levels of these genes were lower in MxMYB1 expressing transgenic Arabidopsis plants as compared with wild type plants under both Fe-normal and Fe-deficient conditions.	Iron	380-382	iron-regulated transporter 1	Arabidopsis thaliana	142-148
18523150-5	2008	These hematologic alterations found in Tmprss6(-/-) mice are accompanied by a marked up-regulation of hepcidin, a negative regulator of iron export into plasma.	Iron	136-140	hepcidin antimicrobial peptide	Mus musculus	102-110
19172740-5	2008	Kae1 is an iron protein with an ASKHA fold and Bud32 is an atypical small RIO-type kinase.	Iron	11-15	tRNA N6-adenosine threonylcarbamoyltransferase	Saccharomyces cerevisiae S288C	0-4
18703840-1	2008	Yeast glutaredoxin 3 (Grx3) is a cytosolic protein that regulates the activity of the iron-responsive transcriptional activator Aft1.	Iron	86-90	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	6-20
18703840-1	2008	Yeast glutaredoxin 3 (Grx3) is a cytosolic protein that regulates the activity of the iron-responsive transcriptional activator Aft1.	Iron	86-90	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	22-26
18441084-14	2008	2, when the Fe-fortified diet was fed, BW and ADG responses were both greater (P &lt; 0.01) to 28 d postweaning when neonates had received Fe injections.	Iron	12-14	ADG	Sus scrofa	39-49
18441084-14	2008	2, when the Fe-fortified diet was fed, BW and ADG responses were both greater (P &lt; 0.01) to 28 d postweaning when neonates had received Fe injections.	Iron	139-141	ADG	Sus scrofa	39-49
18231862-9	2008	Like all LOXs, 5-LOX also has a two-domain structure, the small N-terminal beta-barrel domain and a larger catalytic domain containing a single atom of non-heme iron coordinating with His525, His530, His716 and Ile864.	Iron	161-165	5-lipoxygenase	Solanum tuberosum	15-20
18656261-3	2008	In this study Arabidopsis ETHE1 was over-expressed and purified and shown to bind tightly to 1.2+/-0.2 equivalents of iron.	Iron	118-122	glyoxalase II 3	Arabidopsis thaliana	26-31
18656261-4	2008	(1)H NMR and EPR studies demonstrate that the predominant oxidation state of Fe in ETHE1 is Fe(II), and NMR studies confirm that two histidines are bound to Fe(II).	Iron	77-79	glyoxalase II 3	Arabidopsis thaliana	83-88
18682427-8	2008	In addition, the microarray data also revealed the significant repression of genes such as PORA and AtFRO6 for Chl biosynthesis and iron acquisition, respectively, and, furthermore, implied that there is cross-talk in the Chl biosynthetic pathway among the PORA, AtFRO6 and CHL27 proteins.	Iron	132-136	ferric reduction oxidase 6	Arabidopsis thaliana	100-106
18682427-8	2008	In addition, the microarray data also revealed the significant repression of genes such as PORA and AtFRO6 for Chl biosynthesis and iron acquisition, respectively, and, furthermore, implied that there is cross-talk in the Chl biosynthetic pathway among the PORA, AtFRO6 and CHL27 proteins.	Iron	132-136	ferric reduction oxidase 6	Arabidopsis thaliana	263-269
18682427-8	2008	In addition, the microarray data also revealed the significant repression of genes such as PORA and AtFRO6 for Chl biosynthesis and iron acquisition, respectively, and, furthermore, implied that there is cross-talk in the Chl biosynthetic pathway among the PORA, AtFRO6 and CHL27 proteins.	Iron	132-136	dicarboxylate diiron protein, putative (Crd1)	Arabidopsis thaliana	274-279
18680094-5	2008	The anti-PKCalpha localization is proven by fluorescent microscopy and iron staining.	Iron	71-75	protein kinase C alpha	Bos taurus	9-17
18369597-7	2008	c-Hep mRNA expression significantly increased at 24 h and reached a high level at 48 h, then decreased to normal by 72 h. Therefore, it suggests that iron status was the signal for mRNA expression of hepcidin in liver, while erythrocytes changes in blood were the signals for that of sTf.	Iron	150-154	hepcidin	Larimichthys crocea	200-208
18561026-7	2008	Both apoptotic Fas responses and cytoprotective effects of Tf were associated with significant shifts in plasma iron levels, which quantitatively differed between male and female mice.	Iron	112-116	transferrin	Mus musculus	59-61
18632562-5	2008	We find that myoglobin is responsible for nitrite-dependent NO* generation and cardiomyocyte protein iron-nitrosylation.	Iron	101-105	myoglobin	Mus musculus	13-22
18420243-1	2008	Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier.	Iron	84-86	RoBo-1	Rattus norvegicus	167-195
18406335-3	2008	The overall data demonstrate that under X-ray the iron is photoreduced fairly rapidly, and that the previously reported X-ray structure of ferric Ngb [B. Vallone, K. Nienhaus, M. Brunori, G.U.	Iron	50-54	neuroglobin	Homo sapiens	146-149
18426863-0	2008	Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload.	Iron	96-100	retinol binding protein 4	Homo sapiens	12-37
18426863-2	2008	An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized.	Iron	23-27	retinol binding protein 4	Homo sapiens	59-63
18426863-3	2008	We hypothesized that iron-associated insulin resistance could be behind the impaired insulin action caused by RBP4.	Iron	21-25	retinol binding protein 4	Homo sapiens	110-114
18426863-6	2008	Finally, the effect of iron on RBP4 release was evaluated in vitro in adipose tissue.	Iron	23-27	retinol binding protein 4	Homo sapiens	31-35
18426863-10	2008	Serum RBP4 concentration decreased after iron depletion in type 2 diabetic patients (percent mean difference -13.7 [95% CI -25.4 to -2.04]; P = 0.024).	Iron	41-45	retinol binding protein 4	Homo sapiens	6-10
18426863-11	2008	The iron donor lactoferrin led to increased dose-dependent adipose tissue release of RBP4 (2.4-fold, P = 0.005) and increased RBP4 expression, while apotransferrin and deferoxamine led to decreased RBP4 release.	Iron	4-8	retinol binding protein 4	Homo sapiens	85-89
18426863-11	2008	The iron donor lactoferrin led to increased dose-dependent adipose tissue release of RBP4 (2.4-fold, P = 0.005) and increased RBP4 expression, while apotransferrin and deferoxamine led to decreased RBP4 release.	Iron	4-8	retinol binding protein 4	Homo sapiens	126-130
18426863-11	2008	The iron donor lactoferrin led to increased dose-dependent adipose tissue release of RBP4 (2.4-fold, P = 0.005) and increased RBP4 expression, while apotransferrin and deferoxamine led to decreased RBP4 release.	Iron	4-8	retinol binding protein 4	Homo sapiens	126-130
18426863-12	2008	CONCLUSIONS: The relationship between circulating RBP4 and iron stores, both cross-sectional and after iron depletion, and in vitro findings suggest that iron could play a role in the RBP4-insulin resistance relationship.	Iron	59-63	retinol binding protein 4	Homo sapiens	50-54
18426863-12	2008	CONCLUSIONS: The relationship between circulating RBP4 and iron stores, both cross-sectional and after iron depletion, and in vitro findings suggest that iron could play a role in the RBP4-insulin resistance relationship.	Iron	103-107	retinol binding protein 4	Homo sapiens	50-54
18426863-12	2008	CONCLUSIONS: The relationship between circulating RBP4 and iron stores, both cross-sectional and after iron depletion, and in vitro findings suggest that iron could play a role in the RBP4-insulin resistance relationship.	Iron	103-107	retinol binding protein 4	Homo sapiens	50-54
18521557-0	2008	Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression.	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	66-74
18521557-1	2008	Hepcidin, a small cationic liver derived peptide, is a master regulator of body iron homeostasis.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	0-8
18521557-2	2008	Cytokines and iron availability have so far been identified as regulators of hepcidin expression.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	77-85
18521557-8	2008	Accordingly, the messenger ribonucleic acid (mRNA) concentrations of the hepcidin iron-sensing molecule hemojuvelin were not significantly changed upon Kupffer cell depletion.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	73-81
18521557-8	2008	Accordingly, the messenger ribonucleic acid (mRNA) concentrations of the hepcidin iron-sensing molecule hemojuvelin were not significantly changed upon Kupffer cell depletion.	Iron	82-86	hemojuvelin BMP co-receptor	Mus musculus	104-115
18521557-10	2008	Our data suggest that Kupffer cells control body iron homeostasis by exerting negative regulatory signals toward hepcidin expression, which may be primarily referred to the secretion of yet unidentified hepcidin-suppressing molecules by Kupffer cells.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	113-121
18397377-2	2008	The ferric-chelate reductase FRO2 and the ferrous iron transporter IRT1 control iron entry from the soil into the root epidermis.	Iron	50-54	iron-regulated transporter 1	Arabidopsis thaliana	67-71
18397377-3	2008	In Arabidopsis, expression of IRT1 and FRO2 is tightly controlled to maintain iron homeostasis, and involves local and long-distance signals, as well as transcriptional and post-transcriptional events.	Iron	78-82	iron-regulated transporter 1	Arabidopsis thaliana	30-34
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	12-16	iron-regulated transporter 1	Arabidopsis thaliana	167-171
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	12-16	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	330-338
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	12-16	natural resistance associated macrophage protein 4	Arabidopsis thaliana	343-351
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	330-338
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	natural resistance associated macrophage protein 4	Arabidopsis thaliana	343-351
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	330-338
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	natural resistance associated macrophage protein 4	Arabidopsis thaliana	343-351
18353247-0	2008	HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.	Iron	91-95	hereditary hemochromatosis protein	Cricetulus griseus	0-3
18353247-0	2008	HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.	Iron	91-95	transferrin receptor protein 2	Cricetulus griseus	21-43
18353247-1	2008	Mutations in either HFE or transferrin receptor 2 (TfR2) cause decreased expression of the iron regulatory hormone hepcidin and hemochromatosis.	Iron	91-95	hereditary hemochromatosis protein	Cricetulus griseus	20-23
18353247-1	2008	Mutations in either HFE or transferrin receptor 2 (TfR2) cause decreased expression of the iron regulatory hormone hepcidin and hemochromatosis.	Iron	91-95	transferrin receptor protein 2	Cricetulus griseus	27-49
18353247-1	2008	Mutations in either HFE or transferrin receptor 2 (TfR2) cause decreased expression of the iron regulatory hormone hepcidin and hemochromatosis.	Iron	91-95	transferrin receptor protein 2	Cricetulus griseus	51-55
18353247-5	2008	The co-expression of HFE in cells expressing TfR2 led to increased affinity for diferric transferrin, increased transferrin-dependent iron uptake, and relative resistance to iron chelation.	Iron	134-138	hereditary hemochromatosis protein	Cricetulus griseus	21-24
18353247-5	2008	The co-expression of HFE in cells expressing TfR2 led to increased affinity for diferric transferrin, increased transferrin-dependent iron uptake, and relative resistance to iron chelation.	Iron	134-138	transferrin receptor protein 2	Cricetulus griseus	45-49
18353247-5	2008	The co-expression of HFE in cells expressing TfR2 led to increased affinity for diferric transferrin, increased transferrin-dependent iron uptake, and relative resistance to iron chelation.	Iron	174-178	hereditary hemochromatosis protein	Cricetulus griseus	21-24
18353247-5	2008	The co-expression of HFE in cells expressing TfR2 led to increased affinity for diferric transferrin, increased transferrin-dependent iron uptake, and relative resistance to iron chelation.	Iron	174-178	transferrin receptor protein 2	Cricetulus griseus	45-49
18451267-1	2008	Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of body iron content.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	0-8
18451267-1	2008	Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of body iron content.	Iron	103-107	hepcidin antimicrobial peptide	Mus musculus	0-8
18451267-2	2008	Several proteins induce expression of the hepcidin-encoding gene Hamp in response to infection or high levels of iron.	Iron	113-117	hepcidin antimicrobial peptide	Mus musculus	42-50
18451267-2	2008	Several proteins induce expression of the hepcidin-encoding gene Hamp in response to infection or high levels of iron.	Iron	113-117	hepcidin antimicrobial peptide	Mus musculus	65-69
18451267-3	2008	However, mechanism(s) of Hamp suppression during iron depletion are poorly understood.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	25-29
18451267-5	2008	The mask phenotype results from reduced absorption of dietary iron caused by high levels of hepcidin and is due to a splicing defect in the transmembrane serine protease 6 gene Tmprss6.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	92-100
18189270-0	2008	Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats.	Iron	83-87	RoBo-1	Rattus norvegicus	10-14
18319250-5	2008	Our results support the idea that the surface of the beta-sheet, adjacent to the acidic, iron binding ridge, is important for interaction of Yfh1 with the Fe-S cluster scaffold and point to a critical role for frataxin in Fe-S cluster biogenesis.	Iron	89-93	ferroxidase	Saccharomyces cerevisiae S288C	141-145
18319250-5	2008	Our results support the idea that the surface of the beta-sheet, adjacent to the acidic, iron binding ridge, is important for interaction of Yfh1 with the Fe-S cluster scaffold and point to a critical role for frataxin in Fe-S cluster biogenesis.	Iron	155-157	ferroxidase	Saccharomyces cerevisiae S288C	141-145
18546093-2	2008	It is postulated that Mn(III)-Tf can exploit the same transferrin-receptor-dependent and -independent metabolic pathways used by hepatocytes to transport the iron analog Fe(III)-Tf.	Iron	158-162	transferrin	Mus musculus	54-65
18064607-1	2008	Lipocalin 2 (LCN2), a secreted protein of the lipocalin family, induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore.	Iron	159-163	lipocalin 2	Homo sapiens	0-11
18064607-1	2008	Lipocalin 2 (LCN2), a secreted protein of the lipocalin family, induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore.	Iron	159-163	lipocalin 2	Homo sapiens	13-17
18281282-0	2008	Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.	Iron	74-78	Bol2p	Saccharomyces cerevisiae S288C	27-31
18281282-0	2008	Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.	Iron	126-130	Bol2p	Saccharomyces cerevisiae S288C	27-31
18281282-1	2008	The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive transcription factor Aft1 in regulating the expression of the iron transport system in Saccharomyces cerevisiae is not known.	Iron	82-86	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	118-122
18281282-1	2008	The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive transcription factor Aft1 in regulating the expression of the iron transport system in Saccharomyces cerevisiae is not known.	Iron	159-163	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	118-122
18281282-2	2008	Using a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a complex that interprets the signal derived from mitochondrial Fe-S synthesis.	Iron	164-168	Bol2p	Saccharomyces cerevisiae S288C	77-81
18281282-3	2008	We found that mutations in FRA1 (YLL029W) and FRA2 (YGL220W) led to an increase in transcription of the iron regulon.	Iron	104-108	Bol2p	Saccharomyces cerevisiae S288C	46-50
18281282-4	2008	In cells incubated in high iron medium, deletion of either FRA gene results in the translocation of the low iron-sensing transcription factor Aft1 into the nucleus, where it occupies the FET3 promoter.	Iron	27-31	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	142-146
18281282-4	2008	In cells incubated in high iron medium, deletion of either FRA gene results in the translocation of the low iron-sensing transcription factor Aft1 into the nucleus, where it occupies the FET3 promoter.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	142-146
18281282-7	2008	We show that Fra1 and Fra2 interact in the cytosol in an iron-independent fashion.	Iron	57-61	Bol2p	Saccharomyces cerevisiae S288C	22-26
18281282-8	2008	The Fra1-Fra2 complex binds to Grx3 and Grx4, two cytosolic monothiol glutaredoxins, in an iron-independent fashion.	Iron	91-95	Bol2p	Saccharomyces cerevisiae S288C	9-13
18281282-8	2008	The Fra1-Fra2 complex binds to Grx3 and Grx4, two cytosolic monothiol glutaredoxins, in an iron-independent fashion.	Iron	91-95	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	31-35
18027835-4	2008	The reticulocyte hemoglobin content (CHr or Ret-He) provides an indirect measure of the functional iron available for new red blood cell production over the previous 3-4 days.	Iron	99-103	chromate resistance; sulfate transport	Homo sapiens	37-40
18287331-0	2008	Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.	Iron	65-69	neogenin 1	Homo sapiens	95-103
17987273-0	2008	Liver ischemia and ischemia-reperfusion induces and trafficks the multi-specific metal transporter Atp7b to bile duct canaliculi: possible preferential transport of iron into bile.	Iron	165-169	ATPase copper transporting beta	Homo sapiens	99-104
17987273-9	2008	Thus, we conclude that liver ischemia and ischemia-reperfusion induction and trafficking Atp7b to the bile duct canaliculi may contribute to preferential iron transport into bile.	Iron	154-158	ATPase copper transporting beta	Homo sapiens	89-94
18504967-2	2008	We used X-ray absorption fine structure (EXAFS) spectroscopy to determine the binding mode and oxidation state of iron in solutions initially containing only iron(III) and fulvic acid at pHs 2 and 4.	Iron	114-118	polyhomeotic homolog 2	Homo sapiens	187-198
18504967-6	2008	Iron(III) was reduced to iron(II) with time at pH 2, whereas no significant reduction occurred at pH 4.	Iron	0-4	polyhomeotic homolog 2	Homo sapiens	47-51
18504967-6	2008	Iron(III) was reduced to iron(II) with time at pH 2, whereas no significant reduction occurred at pH 4.	Iron	25-29	polyhomeotic homolog 2	Homo sapiens	47-51
18504967-8	2008	However, the isolated precipitate of the pH 2 sample (&gt;0.45 microm) showed Fe...Fe distances, indicating the presence of tightly packed iron(III) trimers and/or clusters of corner-sharing octahedra.	Iron	78-80	polyhomeotic homolog 2	Homo sapiens	41-45
18227070-7	2008	First, ISC depletion activates the iron-responsive transcription factors Aft1/2p leading to increased cellular iron acquisition.	Iron	35-39	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	73-80
18227070-7	2008	First, ISC depletion activates the iron-responsive transcription factors Aft1/2p leading to increased cellular iron acquisition.	Iron	111-115	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	73-80
18271587-3	2008	The iron atoms at the two sites have distinct geometric features, as revealed in their molecular structures, and distinct electronic structures, as shown by Mossbauer spectroscopy, although both are high spin (S = 2).	Iron	4-8	spindlin 1	Homo sapiens	204-208
18245813-7	2008	Iron depletion of Sprague-Dawley rats increased HIF-1alpha expression, improved glucose clearance, and was associated with up-regulation of insulin receptor and Akt/PKB levels and of glucose transport in hepatic tissue.	Iron	0-4	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	48-58
18061239-8	2008	The high efficiency of the composite Fe(0)/Fe3O4 for Cr(VI) reduction is discussed in terms of a special mechanism where an electron is transferred from Fe(0) to magnetite to reduce Fe(oct)3+ to Fe(oct)2+, which is active for Cr(VI) reduction.	Iron	153-158	POU class 2 homeobox 2	Homo sapiens	195-203
18368618-4	2008	Both TP types contained a variety of transition metals, including zinc (Zn), copper (Cu), aluminum, and iron.	Iron	104-108	transition protein 2	Rattus norvegicus	5-7
18336670-10	2008	The regulatory hormone for iron homeostasis, hepcidin is downregulated in ethanol-loaded mice liver.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	45-53
18287370-0	2008	Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia.	Iron	30-34	non-symbiotic hemoglobin	Zea mays	83-93
18086897-0	2008	Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes.	Iron	37-39	iron-sulfur cluster assembly factor IBA57	Homo sapiens	14-20
18162582-0	2008	Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.	Iron	104-108	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	0-5
18162582-4	2008	Microarray analysis showed that Isc1p deficiency up-regulated the iron regulon leading to increased levels of iron, which is known to catalyze the production of the highly reactive hydroxyl radicals via the Fenton reaction.	Iron	66-70	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	32-37
18162582-4	2008	Microarray analysis showed that Isc1p deficiency up-regulated the iron regulon leading to increased levels of iron, which is known to catalyze the production of the highly reactive hydroxyl radicals via the Fenton reaction.	Iron	110-114	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	32-37
18162582-9	2008	These results indicate that Isc1p plays an important role in the regulation of cellular redox homeostasis, through modulation of iron levels, and of apoptosis.	Iron	129-133	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	28-33
18282105-3	2008	In this study, we characterized the roles of the CFT1 and CFT2 genes that encode C. neoformans orthologs of the Saccharomyces cerevisiae high-affinity iron permease FTR1.	Iron	151-155	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	165-169
18282105-8	2008	Overall, these results indicate that C. neoformans utilizes iron sources within the host (e.g., holo-transferrin) that require Cft1 and a reductive iron uptake system.	Iron	60-64	transferrin	Mus musculus	101-112
18282105-8	2008	Overall, these results indicate that C. neoformans utilizes iron sources within the host (e.g., holo-transferrin) that require Cft1 and a reductive iron uptake system.	Iron	148-152	transferrin	Mus musculus	101-112
17938254-0	2008	Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.	Iron	78-82	hemojuvelin BMP co-receptor	Mus musculus	34-45
17938254-1	2008	The liver peptide hepcidin regulates iron absorption and recycling.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	18-26
17938254-4	2008	s-HJV is decreased by iron in vitro and increased by iron deficiency in vivo.	Iron	22-26	hemojuvelin BMP co-receptor	Mus musculus	2-5
17938254-10	2008	The release of s-HJV might be a tissue-specific mechanism, signaling the local iron requests of hypoxic skeletal muscles independently of the oxygen status of the liver.	Iron	79-83	hemojuvelin BMP co-receptor	Mus musculus	17-20
17962361-6	2008	Plasma membrane localization of ferroportin was studied by selective biotinylation of apical and basolateral membrane domains; Hepc induced rapid internalization of ferroportin in J774 cells but not in Caco-2 cells These results indicate that the effect of Hepc is cell dependent: in macrophages it inhibits iron export by inducing ferroportin degradation, whereas in enterocytes it inhibits apical iron uptake by inhibiting DMT1 transcription.	Iron	308-312	hepcidin antimicrobial peptide	Mus musculus	127-131
17962361-6	2008	Plasma membrane localization of ferroportin was studied by selective biotinylation of apical and basolateral membrane domains; Hepc induced rapid internalization of ferroportin in J774 cells but not in Caco-2 cells These results indicate that the effect of Hepc is cell dependent: in macrophages it inhibits iron export by inducing ferroportin degradation, whereas in enterocytes it inhibits apical iron uptake by inhibiting DMT1 transcription.	Iron	399-403	hepcidin antimicrobial peptide	Mus musculus	127-131
18190883-3	2008	Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism.	Iron	126-130	lipocalin 2	Homo sapiens	0-11
17910970-9	2008	Iron and iron-bearing clays reduced the effective elution rates of both RDX and TNT.	Iron	0-4	radixin	Homo sapiens	72-75
17910970-9	2008	Iron and iron-bearing clays reduced the effective elution rates of both RDX and TNT.	Iron	9-13	radixin	Homo sapiens	72-75
18166355-8	2008	CONCLUSIONS: HCV-induced reactive oxygen species may down-regulate hepcidin transcription through inhibition of C/EBPalpha DNA binding activity by C/EBP homology protein, which in turn leads to increased duodenal iron transport and macrophage iron release, causing hepatic iron accumulation.	Iron	213-217	hepcidin antimicrobial peptide	Mus musculus	67-75
18166355-8	2008	CONCLUSIONS: HCV-induced reactive oxygen species may down-regulate hepcidin transcription through inhibition of C/EBPalpha DNA binding activity by C/EBP homology protein, which in turn leads to increased duodenal iron transport and macrophage iron release, causing hepatic iron accumulation.	Iron	243-247	hepcidin antimicrobial peptide	Mus musculus	67-75
18166355-8	2008	CONCLUSIONS: HCV-induced reactive oxygen species may down-regulate hepcidin transcription through inhibition of C/EBPalpha DNA binding activity by C/EBP homology protein, which in turn leads to increased duodenal iron transport and macrophage iron release, causing hepatic iron accumulation.	Iron	243-247	hepcidin antimicrobial peptide	Mus musculus	67-75
17962718-3	2008	The purpose of this study was to investigate iron incorporation by human endometrial cells and to test whether iron may stimulate expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1.	Iron	111-115	intercellular adhesion molecule 1	Homo sapiens	144-184
17932693-8	2008	The spin concentration determined for Fe3+-desferrioxamine of known Fe3+ concentration was anomalously low suggesting the presence of EPR-silent multimeric iron species in solution.	Iron	156-160	spindlin 1	Homo sapiens	4-8
18316319-7	2008	On the contrary, transcripts of a housekeeping ATPase isoform, CsHA2, were not detected in root hairs, suggesting that Fe-deficiency-induced acidification is predominantly mediated by CsHA1.	Iron	119-121	plasma membrane ATPase 4	Cucumis sativus	63-68
17898788-9	2008	A24 induces TfR-1 endocytosis in lysosomal compartments where the receptor is degraded leading to intracellular iron deprivation.	Iron	112-116	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	0-3
17471497-9	2007	In summary, our results indicate that iron chelator-induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1.	Iron	38-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-162
17471497-10	2007	A possible link between iron status and two additional transcription factors, that is, CREB and Egr-1, rather than NF-kappaB, was also suggested.	Iron	24-28	cAMP responsive element binding protein 1	Homo sapiens	87-91
18048325-8	2007	Strong evidence is provided for the involvement of an iron-sulfur cluster in the remarkable chemical rearrangement reaction catalyzed by the THIC protein for which there is no chemical precedent.	Iron	54-58	thiaminC	Arabidopsis thaliana	141-145
17916643-10	2007	Finally, the preincubation of permeabilized Caco-2 cells with purified PON2 led to a protection against iron-ascorbate-induced lipid peroxidation.	Iron	104-108	paraoxonase 2	Homo sapiens	71-75
18041653-16	2007	In contrast, iron plus ionophore 8-hydroxyquinoline evoked GP IIb/IIIa activation.	Iron	13-17	integrin subunit alpha 2b	Homo sapiens	59-65
18041653-19	2007	In conclusion, the results indicated that oxidant systems external to platelets did not activate GP IIb/IIIa receptors while increased intra-platelet iron was associated with appearance of cytosolic oxidizing species and with GP IIb/IIIa receptor activation.	Iron	150-154	integrin subunit alpha 2b	Homo sapiens	226-232
17893144-0	2007	An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase.	Iron	3-7	DNA primase subunit 2	Homo sapiens	55-58
17655522-2	2007	They have high homologies with iron permease ScFtr1 and ferroxidase ScFet3 of Saccharomyces cerevisiae at the amino acid level.	Iron	31-35	ferroxidase	Saccharomyces cerevisiae S288C	56-67
17884090-1	2007	Ferrochelatase (protoheme ferrolyase, EC 4.99.1.1) is the terminal enzyme in heme biosynthesis and catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme).	Iron	126-138	ferrochelatase	Homo sapiens	0-14
17898131-6	2007	Cell sorting analysis indicated that iron-labeled cells were enriched for cell types positive for the myelomonocytic marker (CD11b/c) and the B lymphocyte marker (CD45RA) and depleted in the T cell marker (CD3).	Iron	37-41	integrin subunit alpha M	Homo sapiens	125-130
17689119-1	2007	Hepcidin, the principal regulator of the iron metabolism, is up-regulated in response to inflammatory stimuli, bone morphogenic proteins (BMPs) and iron excess.	Iron	41-45	hepcidin antimicrobial peptide	Mus musculus	0-8
17689119-1	2007	Hepcidin, the principal regulator of the iron metabolism, is up-regulated in response to inflammatory stimuli, bone morphogenic proteins (BMPs) and iron excess.	Iron	148-152	hepcidin antimicrobial peptide	Mus musculus	0-8
17965933-5	2007	The aim of present study was to evaluate the effects of NO produced by neuronal nitric oxide synthase (nNOS) on iron-induced neuronal death.	Iron	112-116	nitric oxide synthase 1	Rattus norvegicus	71-101
17965933-5	2007	The aim of present study was to evaluate the effects of NO produced by neuronal nitric oxide synthase (nNOS) on iron-induced neuronal death.	Iron	112-116	nitric oxide synthase 1	Rattus norvegicus	103-107
17932563-4	2007	The level of production of hepcidin, an important player in the pathogenesis of the anemia of inflammation, was significantly decreased in Hri-/- mice, accompanied by decreased splenic macrophage iron content and increased serum iron content.	Iron	196-200	hepcidin antimicrobial peptide	Mus musculus	27-35
17932563-4	2007	The level of production of hepcidin, an important player in the pathogenesis of the anemia of inflammation, was significantly decreased in Hri-/- mice, accompanied by decreased splenic macrophage iron content and increased serum iron content.	Iron	229-233	hepcidin antimicrobial peptide	Mus musculus	27-35
17804076-2	2007	Iron deposition into horse spleen ferritin (HoSF) occurs using ferricyanide ion, 2,6-dichlorophenol-indophenol, and several redox proteins: cytochrome c, stellacyanin, and ceruloplasmin.	Iron	0-4	ceruloplasmin	Equus caballus	172-185
17804076-3	2007	Cytochrome c also loads iron into recombinant human H-chain (rHF), human L-chain (rLF), and A. vinelandii bacterioferritin (AvBF).	Iron	24-28	RLF zinc finger	Rattus norvegicus	82-85
17663481-0	2007	Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx.	Iron	96-100	RoBo-1	Rattus norvegicus	0-28
17663481-2	2007	We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in this SN iron accumulation process.	Iron	69-73	RoBo-1	Rattus norvegicus	86-114
17663481-2	2007	We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in this SN iron accumulation process.	Iron	69-73	RoBo-1	Rattus norvegicus	116-120
17663481-3	2007	To investigate this, we first observed the cellular expression of DMT1 in rat SN, both with the iron response element (+IRE) and without the IRE (-IRE) forms.	Iron	96-100	RoBo-1	Rattus norvegicus	66-70
17663481-5	2007	We further observed the relationship between the increased iron influx and DMT1 expression in 6-hydroxydopamine (6-OHDA)-treated C6 cells.	Iron	59-63	RoBo-1	Rattus norvegicus	75-79
17663481-10	2007	Increased DMT1+IRE expression is the mechanism behind ferrous iron influx induced by 6-OHDA treatment in C6 cells.	Iron	62-66	RoBo-1	Rattus norvegicus	10-14
17663481-11	2007	This may give some evidence for the involvement of DMT1 in the iron accumulation in PD.	Iron	63-67	RoBo-1	Rattus norvegicus	51-55
17949489-1	2007	BACKGROUND: Hereditary hemochromatosis (HH) encompasses genetic disorders of iron overload characterized by deficient expression or function of the iron-regulatory hormone hepcidin.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	172-180
17949489-3	2007	Hepcidin inhibits iron export from cells into plasma.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
17681384-1	2007	Haptoglobin (Hp) is a plasma protein with haemoglobin binding capacity important in maintaining the iron homeostasis and in disease processes influenced by iron metabolism.	Iron	100-104	haptoglobin	Bos taurus	0-11
17681384-1	2007	Haptoglobin (Hp) is a plasma protein with haemoglobin binding capacity important in maintaining the iron homeostasis and in disease processes influenced by iron metabolism.	Iron	156-160	haptoglobin	Bos taurus	0-11
17660359-0	2007	FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii.	Iron	145-149	uncharacterized protein	Chlamydomonas reinhardtii	137-141
17660359-1	2007	Previously, we had identified FOX1 and FTR1 as iron deficiency-inducible components of a high-affinity copper-dependent iron uptake pathway in Chlamydomonas.	Iron	47-51	uncharacterized protein	Chlamydomonas reinhardtii	39-43
17660359-1	2007	Previously, we had identified FOX1 and FTR1 as iron deficiency-inducible components of a high-affinity copper-dependent iron uptake pathway in Chlamydomonas.	Iron	120-124	uncharacterized protein	Chlamydomonas reinhardtii	39-43
17660359-2	2007	In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replete cells.	Iron	206-210	uncharacterized protein	Chlamydomonas reinhardtii	118-122
17660359-2	2007	In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replete cells.	Iron	206-210	uncharacterized protein	Chlamydomonas reinhardtii	127-131
17660359-2	2007	In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replete cells.	Iron	228-232	uncharacterized protein	Chlamydomonas reinhardtii	118-122
17660359-2	2007	In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replete cells.	Iron	228-232	uncharacterized protein	Chlamydomonas reinhardtii	127-131
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	83-87	uncharacterized protein	Chlamydomonas reinhardtii	55-59
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	83-87	uncharacterized protein	Chlamydomonas reinhardtii	123-127
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	55-59
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	123-127
17919498-0	2007	Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.	Iron	28-32	haptoglobin	Mus musculus	8-19
17919498-2	2007	Haptoglobin-null mice were previously shown to have an altered heme-iron distribution, thus reproducing what occurs in humans in cases of congenital or acquired anhaptoglobinemia.	Iron	68-72	haptoglobin	Mus musculus	0-11
17919498-3	2007	Here, we report the analysis of iron homeostasis in haptoglobin-null mice.	Iron	32-36	haptoglobin	Mus musculus	52-63
17919498-7	2007	RESULTS: Analysis of intestinal iron transport reveals that haptoglobin-null mice export significantly more iron from the duodenal mucosa to plasma compared with control counterparts.	Iron	32-36	haptoglobin	Mus musculus	60-71
17919498-7	2007	RESULTS: Analysis of intestinal iron transport reveals that haptoglobin-null mice export significantly more iron from the duodenal mucosa to plasma compared with control counterparts.	Iron	108-112	haptoglobin	Mus musculus	60-71
17919498-9	2007	Up-regulation of the ferroportin transcript, but not of the protein, also occurs in haptoglobin-null spleen macrophages, which accumulate free hemoglobin-derived iron.	Iron	162-166	haptoglobin	Mus musculus	84-95
17919498-11	2007	CONCLUSIONS: Taking together these data, we suggest that haptoglobin, by controlling plasma levels of hemoglobin, participates in the regulation of ferroportin expression, thus contributing to the regulation of iron transfer from duodenal mucosa to plasma.	Iron	211-215	haptoglobin	Mus musculus	57-68
17725326-0	2007	Contributions of the protein environment to the midpoint potentials of the A1 phylloquinones and the Fx iron-sulfur cluster in photosystem I. Electrostatic calculations have predicted that the partial negative charge associated with D575PsaB plays a significant role in modulating the midpoint potentials of the A1A and A1B phylloquinones in photosystem I.	Iron	32-36	alpha-1-B glycoprotein	Homo sapiens	320-323
21694167-0	2007	Noncollinear magnetism and exchange interaction in spin-spiral structures of thin film Fe(110).	Iron	87-89	spindlin 1	Homo sapiens	51-55
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	184-188	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	16-23
17516080-12	2007	Taken together, BHLH038, BHLH039, BHLH100 and BHLH101 function differently from FIT and may be involved in mediating a signal related to iron deficiency-induced stress and/or internal iron homeostasis.	Iron	184-188	basic helix-loop-helix protein 100	Arabidopsis thaliana	34-41
17698960-2	2007	In animal cells, Aco1p also is a cytosolic protein binding to mRNAs to regulate iron metabolism.	Iron	80-84	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	17-22
17293845-5	2007	Most interestingly, AR(-/-) brains showed lowered expression of transferrin and transferrin receptor with less iron deposition and nitrotyrosine accumulation.	Iron	111-115	transferrin	Mus musculus	64-75
17293845-5	2007	Most interestingly, AR(-/-) brains showed lowered expression of transferrin and transferrin receptor with less iron deposition and nitrotyrosine accumulation.	Iron	111-115	transferrin	Mus musculus	80-91
17634261-3	2007	Recently, it was demonstrated that low concentrations of free iron upregulate elastin gene expression in cultured fibroblasts.	Iron	62-66	elastin	Homo sapiens	78-85
17634261-10	2007	Immunohistology demonstrated that fibrillin-3 (FBN3) was disorganized and markedly reduced in amount in aortas of the low-iron chicks.	Iron	122-126	fibrillin 3	Homo sapiens	34-45
17634261-10	2007	Immunohistology demonstrated that fibrillin-3 (FBN3) was disorganized and markedly reduced in amount in aortas of the low-iron chicks.	Iron	122-126	fibrillin 3	Homo sapiens	47-51
17538022-0	2007	Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.	Iron	25-29	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	99-104
17538022-0	2007	Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.	Iron	62-66	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	99-104
17538022-1	2007	Aft1p is an iron-responsive transcriptional activator that plays a central role in maintaining iron homeostasis in Saccharomyces cerevisiae.	Iron	12-16	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
17538022-1	2007	Aft1p is an iron-responsive transcriptional activator that plays a central role in maintaining iron homeostasis in Saccharomyces cerevisiae.	Iron	95-99	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
17538022-2	2007	Aft1p is regulated primarily by iron-induced shuttling of the protein between the nucleus and cytoplasm, but its nuclear import is not regulated by iron.	Iron	32-36	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
17538022-3	2007	Here, we have shown that the nuclear export of Aft1p is promoted in the presence of iron and that Msn5p is the nuclear export receptor (exportin) for Aft1p.	Iron	84-88	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	47-52
17538022-4	2007	Msn5p recognizes Aft1p in the iron-replete condition.	Iron	30-34	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	17-22
17614197-0	2007	Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice.	Iron	14-18	aconitase 1	Mus musculus	40-44
17566985-1	2007	The final step in heme biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (EC 4.99.1.1).	Iron	50-62	ferrochelatase	Homo sapiens	121-135
17566985-1	2007	The final step in heme biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (EC 4.99.1.1).	Iron	50-62	ferrochelatase	Homo sapiens	137-148
17567154-2	2007	Ferrochelatase catalyzes the terminal step in heme biosynthesis, the insertion of ferrous iron into protoporphyrin to form protoheme IX.	Iron	82-94	ferrochelatase	Homo sapiens	0-14
17072551-7	2007	Statistically significant relationships (P&lt;0.01 and r&gt;0.70) were observed between Fe and Cu, Cu and K(+), Cu and Ca(2+), B and Na(+), Na(+) and K(+).	Iron	88-90	carbonic anhydrase 1	Homo sapiens	119-128
17415523-5	2007	Two S. cerevisiae monothiol glutaredoxins with the thioredoxin-like extension, Grx3 and Grx4, are modulators of the transcriptional activator Aft1, which regulates iron uptake in yeast.	Iron	164-168	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	79-83
17415523-5	2007	Two S. cerevisiae monothiol glutaredoxins with the thioredoxin-like extension, Grx3 and Grx4, are modulators of the transcriptional activator Aft1, which regulates iron uptake in yeast.	Iron	164-168	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	142-146
17241724-4	2007	Adding chloride or bromide salts with Fe(0) (1% w/v) greatly enhanced TNT, RDX, and HMX degradation rates in aqueous solution.	Iron	38-43	radixin	Homo sapiens	75-78
17506078-0	2007	Targeting of the mouse Slc39a2 (Zip2) gene reveals highly cell-specific patterns of expression, and unique functions in zinc, iron, and calcium homeostasis.	Iron	126-130	solute carrier family 39 (zinc transporter), member 2	Mus musculus	23-30
17506078-0	2007	Targeting of the mouse Slc39a2 (Zip2) gene reveals highly cell-specific patterns of expression, and unique functions in zinc, iron, and calcium homeostasis.	Iron	126-130	solute carrier family 39 (zinc transporter), member 2	Mus musculus	32-36
17506078-5	2007	Although the Zip2 gene was not essential under conditions of normal dietary zinc, it played an important role in adapting to dietary zinc deficiency during pregnancy, and in the homeostasis of iron in the liver as well as iron and calcium in developing embryos.	Iron	193-197	solute carrier family 39 (zinc transporter), member 2	Mus musculus	13-17
17506078-5	2007	Although the Zip2 gene was not essential under conditions of normal dietary zinc, it played an important role in adapting to dietary zinc deficiency during pregnancy, and in the homeostasis of iron in the liver as well as iron and calcium in developing embryos.	Iron	222-226	solute carrier family 39 (zinc transporter), member 2	Mus musculus	13-17
17401681-4	2007	The aim of the present study was to evaluate the possible protective effect of selegiline, a monoamino-oxidase B (MAO-B) inhibitor used in pharmacotherapy of Parkinson"s disease, against iron-induced oxidative stress in the brain.	Iron	187-191	monoamine oxidase B	Rattus norvegicus	114-119
17264297-0	2007	Physiologic systemic iron metabolism in mice deficient for duodenal Hfe.	Iron	21-25	homeostatic iron regulator	Mus musculus	68-71
17264297-1	2007	Mutations in the Hfe gene result in hereditary hemochromatosis (HH), a disorder characterized by increased duodenal iron absorption and tissue iron overload.	Iron	116-120	homeostatic iron regulator	Mus musculus	17-20
17264297-1	2007	Mutations in the Hfe gene result in hereditary hemochromatosis (HH), a disorder characterized by increased duodenal iron absorption and tissue iron overload.	Iron	143-147	homeostatic iron regulator	Mus musculus	17-20
17264297-2	2007	Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells.	Iron	206-210	homeostatic iron regulator	Mus musculus	47-50
17459792-8	2007	Intraprotein electron transfer (IET) between the Mo and Fe centers in animal SO and bacterial SDH is a key step in the catalysis, which can be studied by laser flash photolysis in the presence of deazariboflavin.	Iron	56-58	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	94-97
17539544-8	2007	The results of pH-controlled DCBR tests using different synthetic species of arsenic solution showed that the humic acid inhibited the MMAA removal of Fe (25%)-diatomite more than arsenite.	Iron	151-153	metabolism of cobalamin associated A	Homo sapiens	135-139
17175108-4	2007	A few years ago, it was discovered that the E. coli AlkB protein represented an iron and 2-oxoglutarate dependent oxygenase capable of repairing methyl lesions in DNA by a novel mechanism, termed oxidative demethylation.	Iron	80-84	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	52-56
16837131-3	2007	The aims of this study were to investigate whether iron chelation, blocking of the human insulin-like growth factor-1 receptor (hIGF1R), or both could upregulate IFN-gammaR2 and enhance the anti-proliferative effect of IFN-gamma.	Iron	51-55	interferon gamma receptor 2	Homo sapiens	162-173
17501093-2	2007	We show that an epitaxial iron alloy with vanadium (V) possesses values of G which are significantly reduced to 35 +/- 5 MHz at 27% V. The result can be understood as the role of spin-orbit coupling in generating relaxation, reduced through the atomic number Z.	Iron	26-30	spindlin 1	Homo sapiens	179-183
17182077-6	2007	Sequential extractions of Cd at time 0 and Cd remaining in soil showed that RFG had mobilized Cd mostly from the fraction bound with Fe and Mn oxides.	Iron	133-135	nuclear receptor coactivator 4	Homo sapiens	76-79
17275689-5	2007	In addition, the "intracellular calcein-chelatable iron pool" was determined in the presence or absence of Hsp70 and found to be related to the sensitivity of nuclear DNA to H(2)O(2).	Iron	51-55	heat shock protein family A (Hsp70) member 4	Homo sapiens	107-112
17255318-1	2007	Genetic iron overload, or hemochromatosis, can be caused by mutations in HFE, hemojuvelin, and hepcidin genes.	Iron	8-12	homeostatic iron regulator	Mus musculus	73-76
17255318-1	2007	Genetic iron overload, or hemochromatosis, can be caused by mutations in HFE, hemojuvelin, and hepcidin genes.	Iron	8-12	hemojuvelin BMP co-receptor	Mus musculus	78-89
17255318-1	2007	Genetic iron overload, or hemochromatosis, can be caused by mutations in HFE, hemojuvelin, and hepcidin genes.	Iron	8-12	hepcidin antimicrobial peptide	Mus musculus	95-103
17298691-11	2007	Transferrin receptor 1 and the Fe-responsive element (IRE)-regulated divalent metal transporter 1 (DMT1) were up regulated; while ferroportin and non-IRE1-regulated DMT1 levels did not change.	Iron	31-33	RoBo-1	Rattus norvegicus	99-103
17298691-11	2007	Transferrin receptor 1 and the Fe-responsive element (IRE)-regulated divalent metal transporter 1 (DMT1) were up regulated; while ferroportin and non-IRE1-regulated DMT1 levels did not change.	Iron	31-33	RoBo-1	Rattus norvegicus	165-169
16927372-0	2007	Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species.	Iron	0-4	TNF receptor associated protein 1	Homo sapiens	74-125
16927372-0	2007	Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species.	Iron	0-4	TNF receptor associated protein 1	Homo sapiens	127-132
17096368-0	2007	Cisplatin upregulates Saccharomyces cerevisiae genes involved in iron homeostasis through activation of the iron insufficiency-responsive transcription factor Aft1.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	159-163
17096368-0	2007	Cisplatin upregulates Saccharomyces cerevisiae genes involved in iron homeostasis through activation of the iron insufficiency-responsive transcription factor Aft1.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	159-163
17096368-3	2007	Interestingly, the expression of all 14 genes is known to be regulated by Aft1, a transcription factor activated in response to iron insufficiency.	Iron	128-132	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	74-78
17096368-5	2007	The active domain of Aft1 necessary for activation of the FET3 promoter by cisplatin is identical to the one required for activation by bathophenanthroline sulfonate, an inhibitor of cellular iron uptake.	Iron	192-196	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	21-25
17096368-7	2007	These findings suggest that cisplatin activates Aft1 through the inhibition of iron uptake into the cells, after which the expression of Aft1 target genes involved in iron uptake might be induced.	Iron	79-83	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	48-52
17096368-7	2007	These findings suggest that cisplatin activates Aft1 through the inhibition of iron uptake into the cells, after which the expression of Aft1 target genes involved in iron uptake might be induced.	Iron	79-83	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	137-141
17096368-7	2007	These findings suggest that cisplatin activates Aft1 through the inhibition of iron uptake into the cells, after which the expression of Aft1 target genes involved in iron uptake might be induced.	Iron	167-171	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	48-52
17096368-7	2007	These findings suggest that cisplatin activates Aft1 through the inhibition of iron uptake into the cells, after which the expression of Aft1 target genes involved in iron uptake might be induced.	Iron	167-171	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	137-141
16935854-6	2007	Liver nonheme Fe concentration increased progressively with age in TfR2 mutant mice compared with wild-type mice.	Iron	14-16	transferrin receptor 2	Mus musculus	67-71
16935854-7	2007	Fe absorption (both duodenal Fe uptake and transfer) was increased in TfR2 mutant mice compared with wild-type mice.	Iron	0-2	transferrin receptor 2	Mus musculus	70-74
16935854-7	2007	Fe absorption (both duodenal Fe uptake and transfer) was increased in TfR2 mutant mice compared with wild-type mice.	Iron	29-31	transferrin receptor 2	Mus musculus	70-74
16935854-8	2007	Likewise, expression of genes participating in duodenal Fe uptake (Dcytb, DMT1) and transfer (ferroportin) were increased in TfR2 mutant mice.	Iron	56-58	transferrin receptor 2	Mus musculus	125-129
16935854-11	2007	Even when compared with Fe-loaded wild-type mice, TfR2 mutant mice had increased Fe absorption, increased duodenal Fe transport gene expression, increased liver Fe uptake, and decreased liver hepcidin expression.	Iron	24-26	transferrin receptor 2	Mus musculus	50-54
16935854-11	2007	Even when compared with Fe-loaded wild-type mice, TfR2 mutant mice had increased Fe absorption, increased duodenal Fe transport gene expression, increased liver Fe uptake, and decreased liver hepcidin expression.	Iron	81-83	transferrin receptor 2	Mus musculus	50-54
16935854-11	2007	Even when compared with Fe-loaded wild-type mice, TfR2 mutant mice had increased Fe absorption, increased duodenal Fe transport gene expression, increased liver Fe uptake, and decreased liver hepcidin expression.	Iron	81-83	transferrin receptor 2	Mus musculus	50-54
16935854-12	2007	In conclusion, despite systemic Fe loading, Fe absorption and liver Fe uptake were increased in TfR2 mutant mice in association with decreased expression of hepcidin.	Iron	44-46	transferrin receptor 2	Mus musculus	96-100
16935854-12	2007	In conclusion, despite systemic Fe loading, Fe absorption and liver Fe uptake were increased in TfR2 mutant mice in association with decreased expression of hepcidin.	Iron	44-46	transferrin receptor 2	Mus musculus	96-100
16935854-13	2007	These findings support a model in which TfR2 is a sensor of Fe status and regulates duodenal Fe absorption and liver Fe uptake.	Iron	60-62	transferrin receptor 2	Mus musculus	40-44
16935854-13	2007	These findings support a model in which TfR2 is a sensor of Fe status and regulates duodenal Fe absorption and liver Fe uptake.	Iron	93-95	transferrin receptor 2	Mus musculus	40-44
16935854-13	2007	These findings support a model in which TfR2 is a sensor of Fe status and regulates duodenal Fe absorption and liver Fe uptake.	Iron	93-95	transferrin receptor 2	Mus musculus	40-44
17068284-0	2007	Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque.	Iron	41-45	haptoglobin	Mus musculus	0-11
17241880-10	2007	RESULTS: Liver-specific TfR2-KO mice develop significant iron overload comparable to complete TfR2-KO mice.	Iron	57-61	transferrin receptor 2	Mus musculus	24-28
17241880-14	2007	CONCLUSIONS: The significant iron loading and modulation of expression of iron-related genes in liver-specific TfR2-KO mice demonstrates that the liver is the primary site for TfR2 expression and activity and that liver-expressed TfR2 is required for the regulation of hepcidin1.	Iron	29-33	transferrin receptor 2	Mus musculus	111-115
17241880-14	2007	CONCLUSIONS: The significant iron loading and modulation of expression of iron-related genes in liver-specific TfR2-KO mice demonstrates that the liver is the primary site for TfR2 expression and activity and that liver-expressed TfR2 is required for the regulation of hepcidin1.	Iron	74-78	transferrin receptor 2	Mus musculus	111-115
17241880-14	2007	CONCLUSIONS: The significant iron loading and modulation of expression of iron-related genes in liver-specific TfR2-KO mice demonstrates that the liver is the primary site for TfR2 expression and activity and that liver-expressed TfR2 is required for the regulation of hepcidin1.	Iron	74-78	transferrin receptor 2	Mus musculus	176-180
17241880-14	2007	CONCLUSIONS: The significant iron loading and modulation of expression of iron-related genes in liver-specific TfR2-KO mice demonstrates that the liver is the primary site for TfR2 expression and activity and that liver-expressed TfR2 is required for the regulation of hepcidin1.	Iron	74-78	transferrin receptor 2	Mus musculus	176-180
17945001-5	2007	Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis.	Iron	168-172	homeostatic iron regulator	Mus musculus	0-3
17945001-5	2007	Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis.	Iron	168-172	homeostatic iron regulator	Mus musculus	208-211
17945001-5	2007	Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis.	Iron	251-255	homeostatic iron regulator	Mus musculus	0-3
17945001-5	2007	Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis.	Iron	251-255	homeostatic iron regulator	Mus musculus	208-211
17945001-8	2007	CONCLUSION: The expression patterns identified in this study contribute novel insights into the mechanisms of Hfe action and potential candidate genes for iron loading severity.	Iron	155-159	homeostatic iron regulator	Mus musculus	110-113
17187402-4	2007	Transcript levels of genes involved in intestinal iron absorption, including Dcytb, DMT1, and ferroportin, are significantly elevated in the absence of hepcidin.	Iron	50-54	cytochrome b reductase 1	Homo sapiens	77-82
17376729-4	2007	However, despite significant effort, the role of the HFE protein in iron metabolism is still unknown.	Iron	68-72	homeostatic iron regulator	Mus musculus	53-56
17603231-9	2007	RESULTS: After adjustment for confounding variables, a model consisting of serum levels of iron, transferrin saturation (TSAT), and BMI which accounted for 62% of the variance in MeS, determined only BMI as an independent marker (according to ATP-III criteria).	Iron	91-95	MKS transition zone complex subunit 1	Homo sapiens	179-182
17603231-10	2007	But, serum glucose level, iron, waist and total fat mass accounted for 68% of the variance in MeS, according to IDF criteria.	Iron	26-30	MKS transition zone complex subunit 1	Homo sapiens	94-97
17603231-12	2007	BMI and iron, as independent variables, contributed to 29% of the variance in IR HOMA, the sensitive marker of MeS.	Iron	8-12	MKS transition zone complex subunit 1	Homo sapiens	111-114
17603231-13	2007	CONCLUSION: The present study demonstrated that serum iron participated together with independent predictors, glucose and BMI, in the pathogenesis of IR and MeS of ESRD patients on maintenance HD.	Iron	54-58	MKS transition zone complex subunit 1	Homo sapiens	157-160
17404382-12	2007	All three IRT1 genes were able to facilitate growth on low Fe concentrations.	Iron	59-61	iron-regulated transporter 1	Arabidopsis thaliana	10-14
17116231-4	2007	The non-haem iron increase was associated with induction of haem oxygenase (HO)-1 in neurones, microglia and capillary endothelial cells, whereas HO-2 levels remained unchanged, suggesting that the non-haem iron increase might be the result of HO-1-mediated haem degradation.	Iron	13-17	heme oxygenase 1	Rattus norvegicus	60-81
17008316-2	2006	The quinol oxidase (Q(o)) site in this complex oxidizes a hydroquinone (quinol), reducing two one-electron carriers, a low potential cytochrome b heme and the "Rieske" iron-sulfur cluster.	Iron	168-172	mitochondrially encoded cytochrome b	Homo sapiens	133-145
16920733-11	2006	Recently, Ndrg-1 expression was demonstrated to be regulated by cellular iron levels and induced by iron chelators.	Iron	73-77	N-myc downstream regulated 1	Homo sapiens	10-16
16920733-11	2006	Recently, Ndrg-1 expression was demonstrated to be regulated by cellular iron levels and induced by iron chelators.	Iron	100-104	N-myc downstream regulated 1	Homo sapiens	10-16
16920733-13	2006	The discovery that iron chelators also increase Ndrg-1 expression further augments their antitumor activity and provides a novel strategy for the treatment of cancer and its metastasis.	Iron	19-23	N-myc downstream regulated 1	Homo sapiens	48-54
17087784-0	2006	Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status.	Iron	88-92	cytochrome b reductase 1	Homo sapiens	22-43
17087784-1	2006	BACKGROUND: The brush border ferric reductase (Dcytb) is critical for the absorption of dietary iron and appears to be expressed on the duodenal enterocyte brush border.	Iron	96-100	cytochrome b reductase 1	Homo sapiens	47-52
17087784-3	2006	This study investigated Dcytb expression in patients with normal iron status or mild iron deficiency and its relationships with enterocyte iron status.	Iron	65-69	cytochrome b reductase 1	Homo sapiens	24-29
17087784-3	2006	This study investigated Dcytb expression in patients with normal iron status or mild iron deficiency and its relationships with enterocyte iron status.	Iron	85-89	cytochrome b reductase 1	Homo sapiens	24-29
17087784-8	2006	RESULTS: The LM process showed a strong negative correlation between immunolabelling intensity of Dcytb on the enterocyte brush border and serum iron saturation (P &lt; 0.001), but only a weak negative correlation between this antigen and haemoglobin (P = 0.08) or serum ferritin concentrations (P = 0.4).	Iron	145-149	cytochrome b reductase 1	Homo sapiens	98-103
17087784-11	2006	CONCLUSIONS: Enterocyte Dcytb brush border expression is increased even in mild iron deficiency and may be related to serum iron saturation.	Iron	80-84	cytochrome b reductase 1	Homo sapiens	24-29
17092311-6	2006	Surprisingly, transcription of aconitase and the Fe-S subunit of succinate dehydrogenase (SDH2-1) are increased in mutant plants; however, the activity of these proteins is reduced, indicating a role for frataxin in Fe-S cluster assembly or insertion of Fe-S clusters into proteins.	Iron	49-53	succinate dehydrogenase 2-1	Arabidopsis thaliana	90-96
17092311-6	2006	Surprisingly, transcription of aconitase and the Fe-S subunit of succinate dehydrogenase (SDH2-1) are increased in mutant plants; however, the activity of these proteins is reduced, indicating a role for frataxin in Fe-S cluster assembly or insertion of Fe-S clusters into proteins.	Iron	216-220	succinate dehydrogenase 2-1	Arabidopsis thaliana	90-96
17092311-6	2006	Surprisingly, transcription of aconitase and the Fe-S subunit of succinate dehydrogenase (SDH2-1) are increased in mutant plants; however, the activity of these proteins is reduced, indicating a role for frataxin in Fe-S cluster assembly or insertion of Fe-S clusters into proteins.	Iron	216-220	succinate dehydrogenase 2-1	Arabidopsis thaliana	90-96
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	60-64	transferrin	Mus musculus	6-17
16704991-1	2006	Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues.	Iron	66-68	transferrin	Mus musculus	6-17
16928691-5	2006	Thus, the first electron to reduce the ferric iron of heme complexed with rHO-1 must be transferred from FMN.	Iron	46-50	heme oxygenase 1	Rattus norvegicus	74-79
16928691-9	2006	Thus, the final electron for reducing ferric biliverdin-iron chelate to release ferrous iron and biliverdin is apparently provided by the FMN of CPR.	Iron	80-92	cytochrome p450 oxidoreductase	Rattus norvegicus	145-148
18970802-4	2006	After procedure optimization, which requires about 4.25mL of sample and standard per measurement, it was possible to get linear analytical response for iron concentrations between 0.12 and 1.40mgL(-1) and a detection limit of 0.04mgL(-1).	Iron	152-156	LLGL scribble cell polarity complex component 1	Homo sapiens	193-199
17002471-6	2006	The smaller effect of AA on uptake from NaFeEDTA may be related to the higher solubility of NaFeEDTA and/or the strong binding affinity of EDTA for Fe3+, which may prevent AA and duodenal cytochrome b from effectively reducing EDTA-bound Fe.	Iron	42-44	cytochrome b reductase 1	Homo sapiens	179-200
16937262-0	2006	Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading.	Iron	49-53	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	61-71
16939499-2	2006	In a mouse model of beta-thalassaemia, we observed that the liver expressed relatively low levels of hepcidin, which is a key factor in the regulation of iron absorption by the gut and of iron recycling by the reticuloendothelial system.	Iron	154-158	hepcidin antimicrobial peptide	Mus musculus	101-109
16939499-2	2006	In a mouse model of beta-thalassaemia, we observed that the liver expressed relatively low levels of hepcidin, which is a key factor in the regulation of iron absorption by the gut and of iron recycling by the reticuloendothelial system.	Iron	188-192	hepcidin antimicrobial peptide	Mus musculus	101-109
17040095-2	2006	Hydroxypyridinones, e.g., CP20 (3-hydroxy-1,2-dimethylpyridin-4(1H)-one), are used or are under investigation as orally administered iron chelators.	Iron	133-137	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	26-30
17040095-4	2006	We found that iron(III) but not iron(II) binds tightly to both CP20 and ICL670 at pH 7 and higher, compared to nearly complete binding of 1 microM iron(II) to 10 microM desferrioxamine at pH 7.4 The electrode potentials of the hydroxypyridinones shift to more negative values with decreasing pK(a) values at lower concentrations of iron(III) (0.02 mM) and ligand (0.1 mM).	Iron	14-18	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	63-67
16641131-3	2006	In this study, we examined expression of iron import (duodenal cytochrome b (DCYTB), divalent metal transporter 1 (DMT1), and transferrin receptor 1 (TfR1)) and export (hephaestin (HEPH) and ferroportin (FPN)) proteins in colorectal carcinoma.	Iron	41-45	cytochrome b reductase 1	Homo sapiens	54-75
16641131-3	2006	In this study, we examined expression of iron import (duodenal cytochrome b (DCYTB), divalent metal transporter 1 (DMT1), and transferrin receptor 1 (TfR1)) and export (hephaestin (HEPH) and ferroportin (FPN)) proteins in colorectal carcinoma.	Iron	41-45	hephaestin	Homo sapiens	181-185
16641131-8	2006	RESULTS: Perl"s staining showed increased iron in colorectal cancers, and there was a corresponding overexpression of components of the intracellular iron import machinery (DCYTB, DMT1, and TfR1).	Iron	150-154	cytochrome b reductase 1	Homo sapiens	173-178
16641131-9	2006	The iron exporter FPN was also overexpressed, but its intracellular location, combined with reduced HEPH levels, suggests reduced iron efflux in the majority of colorectal cancers examined.	Iron	4-8	hephaestin	Homo sapiens	100-104
17029598-6	2006	Co-localization of iron and Abeta was accompanied by apoptosis, DNA damage, blood-brain barrier (BBB) disruption, as well as dysregulation in the level of the iron-regulatory proteins, ferritin and heme-oxygenase-1.	Iron	19-23	heme oxygenase 1	Oryctolagus cuniculus	198-214
16897469-11	2006	The reaction catalyzed by Bio2 may be subject to biochemical constraints, and the apparent close connection with the mitochondrial Fe-S machinery may account for the reaction being retained within the organelle.	Iron	131-135	Radical SAM superfamily protein	Arabidopsis thaliana	26-30
16829529-7	2006	AtGRXcp expression can also suppress iron accumulation and partially rescue the lysine auxotrophy of yeast grx5 cells.	Iron	37-41	CAX interacting protein 1	Arabidopsis thaliana	0-7
16648237-8	2006	When alveolar macrophages were loaded with transferrin-bound (55)Fe, the subsequent release of (55)Fe was inhibited significantly by LPS.	Iron	65-67	transferrin	Mus musculus	43-54
16648237-8	2006	When alveolar macrophages were loaded with transferrin-bound (55)Fe, the subsequent release of (55)Fe was inhibited significantly by LPS.	Iron	99-101	transferrin	Mus musculus	43-54
16648237-10	2006	These findings are consistent with the current model that HAMP production leads to a decreased iron efflux.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	58-62
16648237-11	2006	Our studies suggest that iron mobilization by alveolar macrophages can be affected by iron and LPS via several pathways, including HAMP-mediated degradation of FPN1, and that these cells may use unique regulatory mechanisms to cope with iron imbalance in the lung.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	131-135
16648237-11	2006	Our studies suggest that iron mobilization by alveolar macrophages can be affected by iron and LPS via several pathways, including HAMP-mediated degradation of FPN1, and that these cells may use unique regulatory mechanisms to cope with iron imbalance in the lung.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	131-135
16648237-11	2006	Our studies suggest that iron mobilization by alveolar macrophages can be affected by iron and LPS via several pathways, including HAMP-mediated degradation of FPN1, and that these cells may use unique regulatory mechanisms to cope with iron imbalance in the lung.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	131-135
16952942-3	2006	Previously uncharacterized potential iron transport systems, including a homologue of the ferrous transporter Feo and a periplasmic binding protein-dependent ATP binding cassette (ABC) transport system, termed Fbp, were identified in the V. cholerae genome sequence.	Iron	37-41	far upstream element (FUSE) binding protein 1	Mus musculus	210-213
16952942-4	2006	Clones encoding either the Feo or the Fbp system exhibited characteristics of iron transporters: both repressed the expression of lacZ cloned under the control of a Fur-regulated promoter in Escherichia coli and also conferred growth on a Shigella flexneri mutant that has a severe defect in iron transport.	Iron	78-82	far upstream element (FUSE) binding protein 1	Mus musculus	38-41
16952942-8	2006	The growth of V. cholerae strains carrying mutations in one or more of the potential iron transport genes indicated that both Feo and Fbp contribute to iron acquisition.	Iron	85-89	far upstream element (FUSE) binding protein 1	Mus musculus	134-137
16952942-8	2006	The growth of V. cholerae strains carrying mutations in one or more of the potential iron transport genes indicated that both Feo and Fbp contribute to iron acquisition.	Iron	152-156	far upstream element (FUSE) binding protein 1	Mus musculus	134-137
17101456-1	2006	Neuroferritinopathy (MIM 606159, also labeled hereditary ferritinopathy and neurodegeneration with brain iron accumulation type 2, NBIA2) is an adult-onset progressive movement disorder caused by mutations in the ferritin light chain gene (FTL1).	Iron	105-109	ferritin light chain	Homo sapiens	213-233
17101458-1	2006	Iron (Fe) is an essential element that is imperative for the redox-driven processes of oxygen transport, electron transport, and DNA synthesis.	Iron	0-4	general transcription factor IIE subunit 1	Homo sapiens	6-8
17026326-2	2006	We found that nearly completely spin-polarized field emission currents can be realized in two and four Fe layers on W(001) and that these systems have the additional advantages of thermal stability and low work functions.	Iron	103-105	spindlin 1	Homo sapiens	32-36
17026326-3	2006	The unusually high spin polarizations of the field emission current is traced to the Fe film"s quantum size effects leading to spin-polarized quantum well states and surface resonance states.	Iron	85-87	spindlin 1	Homo sapiens	19-23
17026326-3	2006	The unusually high spin polarizations of the field emission current is traced to the Fe film"s quantum size effects leading to spin-polarized quantum well states and surface resonance states.	Iron	85-87	spindlin 1	Homo sapiens	127-131
17026327-1	2006	For hcp Fe, these calculations predict no hyperfine magnetic field, consistent with previous experiments.	Iron	8-10	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	4-7
16868025-0	2006	Complex biosynthesis of the muscle-enriched iron regulator RGMc.	Iron	44-48	hemojuvelin BMP co-receptor	Mus musculus	59-63
16868025-2	2006	Mutations in this gene have been linked to the severe iron storage disease, juvenile hemochromatosis, although the mechanisms of action of RGMc in iron metabolism are unknown.	Iron	147-151	hemojuvelin BMP co-receptor	Mus musculus	139-143
16890145-5	2006	Hepatocyte nuclei expressing proliferating cell nuclear antigen (PCNA), a marker of S phase, were significantly increased in the iron-loaded livers, suggesting enhanced proliferation.	Iron	129-133	proliferating cell nuclear antigen	Rattus norvegicus	29-63
16890145-5	2006	Hepatocyte nuclei expressing proliferating cell nuclear antigen (PCNA), a marker of S phase, were significantly increased in the iron-loaded livers, suggesting enhanced proliferation.	Iron	129-133	proliferating cell nuclear antigen	Rattus norvegicus	65-69
16755567-6	2006	In our work, we measured by RQ-PCR the liver mRNA expression of hepcidin and other iron regulatory genes in beta-thalassemia major mouse model (C57Bl/6 Hbb(th3/th3)), and compared it with beta-thalassemia intermedia mouse model (C57Bl/6 Hbb(th3/+)) and control mice.	Iron	83-87	hepcidin antimicrobial peptide	Mus musculus	64-72
16755567-8	2006	Significant down-regulation of hepcidin expression in beta-thalassemia major, despite iron overload, might explain the increased iron absorption typically observed in thalassemia.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	31-39
16755567-8	2006	Significant down-regulation of hepcidin expression in beta-thalassemia major, despite iron overload, might explain the increased iron absorption typically observed in thalassemia.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	31-39
16839620-1	2006	Most iron in mammalian systems is routed to mitochondria to serve as a substrate for ferrochelatase.	Iron	5-9	ferrochelatase	Homo sapiens	85-99
16839620-2	2006	Ferrochelatase inserts iron into protoporphyrin IX to form heme which is incorporated into hemoglobin and cytochromes, the dominant hemoproteins in mammals.	Iron	23-27	ferrochelatase	Homo sapiens	0-14
16773207-5	2006	YC-1 blocked the HIF-1alpha induction by hypoxia, iron chelation, and proteasomal inhibition and also degraded ectopically expressed HIF-1alpha.	Iron	50-54	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4
16770644-0	2006	IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice.	Iron	40-44	aconitase 1	Mus musculus	0-4
16770644-11	2006	The observed IRP2 downmodulation could serve as a means to counteract DOX cardiotoxicity by reducing the "free" cellular iron pool.	Iron	121-125	iron responsive element binding protein 2	Mus musculus	13-17
16825958-4	2006	The immunohistochemical demonstration of neuroglobin in the swollen nuclei and both globins in the hyaline deposits highlights the potential pathogenic importance of 2 other iron-containing proteins in this disease that is largely restricted to brain.	Iron	174-178	neuroglobin	Homo sapiens	41-52
16774310-1	2006	The electronic structure and spin-dependent conductance of a magnetic junction consisting of two Fe-doped carbon nanotubes and a C60 molecule are investigated using a first-principles approach that combines the density functional theory with the nonequilibrium Greens function technique.	Iron	97-99	spindlin 1	Homo sapiens	29-33
16700543-0	2006	Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane.	Iron	13-17	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	42-47
16700543-0	2006	Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane.	Iron	62-66	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	42-47
16700543-1	2006	In high-affinity iron uptake in the yeast Saccharomyces cerevisiae, Fe(II) is oxidized to Fe(III) by the multicopper oxidase, Fet3p, and the Fe(III) produced is transported into the cell via the iron permease, Ftr1p.	Iron	17-21	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	210-215
16700543-4	2006	We examine the (59)Fe uptake kinetics for a number of complexes containing mutant forms of both Fet3p and Ftr1p and demonstrate that a residue in one protein interacts with one in the other protein along the iron trafficking pathway as would be expected in a channeling process.	Iron	19-21	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	106-111
16700543-4	2006	We examine the (59)Fe uptake kinetics for a number of complexes containing mutant forms of both Fet3p and Ftr1p and demonstrate that a residue in one protein interacts with one in the other protein along the iron trafficking pathway as would be expected in a channeling process.	Iron	208-212	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	106-111
16700543-8	2006	We constructed the analogous ferroxidase, permease chimera and demonstrate that it supports iron uptake with a kinetic pattern consistent with a channeling mechanism.	Iron	92-96	ferroxidase	Saccharomyces cerevisiae S288C	29-40
16522632-1	2006	The high affinity iron uptake complex in the yeast plasma membrane (PM) consists of the ferroxidase, Fet3p, and the ferric iron permease, Ftr1p.	Iron	18-22	ferroxidase	Saccharomyces cerevisiae S288C	88-99
16522632-1	2006	The high affinity iron uptake complex in the yeast plasma membrane (PM) consists of the ferroxidase, Fet3p, and the ferric iron permease, Ftr1p.	Iron	18-22	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	138-143
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	122-126	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	75-80
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	122-126	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	141-146
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	151-155	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	75-80
16522632-9	2006	The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM.	Iron	151-155	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	141-146
16647565-8	2006	Importantly, reduced heme synthesis in these cells was restored to normal values by using an iron source that bypasses the transferrin-receptor pathway.	Iron	93-97	transferrin	Mus musculus	123-134
16622025-1	2006	Neutrophil gelatinase-associated lipocalin (NGAL) is a siderophore-binding protein that exerts a bacteriostatic effect by sequestering iron.	Iron	135-139	lipocalin 2	Homo sapiens	0-42
16622025-1	2006	Neutrophil gelatinase-associated lipocalin (NGAL) is a siderophore-binding protein that exerts a bacteriostatic effect by sequestering iron.	Iron	135-139	lipocalin 2	Homo sapiens	44-48
16387364-3	2006	Fe(II) serves as substrate for Fe-uptake by being substrate for Fet3p; the resulting Fet3p-produced Fe(III) is then transported across the membrane via Ftr1p.	Iron	0-2	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	152-157
16387364-4	2006	A model of metabolite channeling of this Fe(III) is tested here by first constructing and kinetically characterizing in Fe-uptake two Fet3p-Ftr1p chimeras in which the multicopper oxidase/ferroxidase domain of Fet3p has been fused to the Ftr1p iron permease.	Iron	41-43	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	140-145
16387364-4	2006	A model of metabolite channeling of this Fe(III) is tested here by first constructing and kinetically characterizing in Fe-uptake two Fet3p-Ftr1p chimeras in which the multicopper oxidase/ferroxidase domain of Fet3p has been fused to the Ftr1p iron permease.	Iron	41-43	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	238-243
16387364-6	2006	Specifically, Fe-uptake through the Fet3p, Ftr1p complex is insensitive to a potential Fe(III) trapping agent - citrate - whereas Fe-uptake via the chimeric proteins is competitively inhibited by this Fe(III) chelator.	Iron	14-16	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	43-48
16387364-6	2006	Specifically, Fe-uptake through the Fet3p, Ftr1p complex is insensitive to a potential Fe(III) trapping agent - citrate - whereas Fe-uptake via the chimeric proteins is competitively inhibited by this Fe(III) chelator.	Iron	36-38	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	43-48
16456084-5	2006	At 2 h, caspase 3 activity was elevated 3.2 +/- 0.3-fold (p &lt; 0.01) in the iron-loaded and DHF-treated ECs, and cell survival, determined 24 h later, decreased 47 +/- 6% (p &lt; 0.01).	Iron	78-82	Death executioner caspase related to Apopain/Yama	Drosophila melanogaster	8-17
16362328-1	2006	The Arabidopsis FRO2 gene encodes the iron deficiency-inducible ferric chelate reductase responsible for reduction of iron at the root surface; subsequent transport of iron across the plasma membrane is carried out by a ferrous iron transporter (IRT1).	Iron	38-42	iron-regulated transporter 1	Arabidopsis thaliana	246-250
16601688-5	2006	Studies in mtm1 mutants indicate that iron inactivation of SOD2 involves the Mrs3p/Mrs4p mitochondrial carriers and iron-binding frataxin (Yfh1p).	Iron	116-120	ferroxidase	Saccharomyces cerevisiae S288C	139-144
16601688-6	2006	A small pool of SOD2-reactive iron also exists under normal iron homeostasis conditions and binds SOD2 when mitochondrial manganese is low.	Iron	30-34	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	16-20
16601688-6	2006	A small pool of SOD2-reactive iron also exists under normal iron homeostasis conditions and binds SOD2 when mitochondrial manganese is low.	Iron	30-34	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	98-102
16601688-6	2006	A small pool of SOD2-reactive iron also exists under normal iron homeostasis conditions and binds SOD2 when mitochondrial manganese is low.	Iron	60-64	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	16-20
16601688-7	2006	The ability to control this reactive pool of iron is critical to maintaining SOD2 activity and has important potential implications for oxidative stress in disorders of iron overload.	Iron	45-49	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	77-81
16328268-1	2006	Iron regulatory proteins (IRP1 and IRP2) bind to iron response elements (IRE) on specific mRNAs, to affect the translation of many proteins involved in iron metabolism.	Iron	0-4	iron responsive element binding protein 2	Rattus norvegicus	35-39
16328268-1	2006	Iron regulatory proteins (IRP1 and IRP2) bind to iron response elements (IRE) on specific mRNAs, to affect the translation of many proteins involved in iron metabolism.	Iron	49-53	iron responsive element binding protein 2	Rattus norvegicus	35-39
16328268-1	2006	Iron regulatory proteins (IRP1 and IRP2) bind to iron response elements (IRE) on specific mRNAs, to affect the translation of many proteins involved in iron metabolism.	Iron	152-156	iron responsive element binding protein 2	Rattus norvegicus	35-39
16418170-4	2006	A significant delay in developmental up-regulation of hepcidin (Hamp), the pivotal hormonal regulator of iron homeostasis, correlated with high levels of Fpn1 expression in hepatic Kupffer cells and duodenal epithelial cells at 7 weeks of age.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	54-62
16418170-4	2006	A significant delay in developmental up-regulation of hepcidin (Hamp), the pivotal hormonal regulator of iron homeostasis, correlated with high levels of Fpn1 expression in hepatic Kupffer cells and duodenal epithelial cells at 7 weeks of age.	Iron	105-109	hepcidin antimicrobial peptide	Mus musculus	64-68
16418170-6	2006	Hamp regulation due to iron did not appear dependent on transcription-level changes of the murine homolog of Hemojuvelin (Rgmc).	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	0-4
16418170-8	2006	Thus, similar to the anemia of chronic disease, these findings demonstrate decreased iron bioavailability due to sustained down-regulation of Fpn1 levels by Hamp.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	157-161
16529490-4	2006	Protonation of 3 using CF3SO3H in CH2Cl2 gives the charge-compensated compound [4,9-{Fe(CO)4}-4-(mu-H)-9,9,9-(CO)3-arachno-9,6-FeCB8H11] (6), in which the B-Fe sigma bond of the precursor has been converted to a B-H right harpoon-up Fe linkage.	Iron	85-87	FECB	Homo sapiens	127-131
16340001-2	2006	Intestinal manganese and iron absorption is mediated by divalent metal transporter 1 (DMT1) and is upregulated in iron deficiency.	Iron	25-29	RoBo-1	Rattus norvegicus	56-84
16340001-2	2006	Intestinal manganese and iron absorption is mediated by divalent metal transporter 1 (DMT1) and is upregulated in iron deficiency.	Iron	25-29	RoBo-1	Rattus norvegicus	86-90
16221503-11	2006	Tumor necrosis factor-alpha regulates the mRNA levels of HAMP, IREG1, DMT1 and TfR2 in cultured hepatocytes from both iron-loaded and control animals.	Iron	118-122	RoBo-1	Rattus norvegicus	70-74
16221503-11	2006	Tumor necrosis factor-alpha regulates the mRNA levels of HAMP, IREG1, DMT1 and TfR2 in cultured hepatocytes from both iron-loaded and control animals.	Iron	118-122	transferrin receptor 2	Rattus norvegicus	79-83
16226281-7	2006	Additionally we determined in HT29 clone 19A cells intracellular iron levels after incubation with hemoglobin/hemin.	Iron	65-69	SLAM family member 7	Homo sapiens	41-44
16226281-14	2006	Intracellular iron increased in hemoglobin/hemin treated HT29 clone 19A cells, reflecting a 40-50% iron uptake for each compound.	Iron	14-18	SLAM family member 7	Homo sapiens	68-71
16518306-8	2006	Mutation screening in FTL identified a G>A change at position 32 (c.-168G>A) in a highly conserved 3 nucleotide motif that forms a loop structure in the iron responsive element (IRE) in the 5"-untranslated region (5"-UTR).	Iron	153-157	ferritin light chain	Homo sapiens	22-25
16239432-0	2006	Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	90-98
16239432-1	2006	The iron requirements of the erythroid compartment modulate the expression of hepcidin in the liver, which in turn alters intestinal iron absorption and iron release from the reticuloendothelial system.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	78-86
16239432-1	2006	The iron requirements of the erythroid compartment modulate the expression of hepcidin in the liver, which in turn alters intestinal iron absorption and iron release from the reticuloendothelial system.	Iron	133-137	hepcidin antimicrobial peptide	Mus musculus	78-86
16239432-1	2006	The iron requirements of the erythroid compartment modulate the expression of hepcidin in the liver, which in turn alters intestinal iron absorption and iron release from the reticuloendothelial system.	Iron	133-137	hepcidin antimicrobial peptide	Mus musculus	78-86
16239432-6	2006	However, this apparent inappropriate regulation of hepcidin correlated with increased transferrin saturation and levels of diferric transferrin in the plasma, which in turn resulted from the reduced capacity of hbd animals to effectively use transferrin-bound iron.	Iron	260-264	hepcidin antimicrobial peptide	Mus musculus	51-59
16239432-6	2006	However, this apparent inappropriate regulation of hepcidin correlated with increased transferrin saturation and levels of diferric transferrin in the plasma, which in turn resulted from the reduced capacity of hbd animals to effectively use transferrin-bound iron.	Iron	260-264	transferrin	Mus musculus	132-143
16239432-6	2006	However, this apparent inappropriate regulation of hepcidin correlated with increased transferrin saturation and levels of diferric transferrin in the plasma, which in turn resulted from the reduced capacity of hbd animals to effectively use transferrin-bound iron.	Iron	260-264	transferrin	Mus musculus	132-143
16239432-7	2006	These data strengthen the proposal that diferric transferrin is a key indicator of body iron requirements.	Iron	88-92	transferrin	Mus musculus	49-60
16229922-0	2006	Iron overload promotes Cyclin D1 expression and alters cell cycle in mouse hepatocytes.	Iron	0-4	cyclin D1	Mus musculus	23-32
16229922-9	2006	Immunobloting analysis demonstrated a strong increase of Cyclin D1 protein expression in iron-overloaded hepatocytes.	Iron	89-93	cyclin D1	Mus musculus	57-66
16229922-11	2006	CONCLUSIONS: Our data demonstrates that Cyclin D1, a protein involved in G1-phase of cell cycle, is overexpressed in the iron-overloaded liver.	Iron	121-125	cyclin D1	Mus musculus	40-49
16229922-12	2006	This iron-induced expression of Cyclin D1 may contribute to development of cell cycle abnormalities, suggesting a role of Cyclin D1 in iron-related hepatocarcinogenesis.	Iron	5-9	cyclin D1	Mus musculus	32-41
16229922-12	2006	This iron-induced expression of Cyclin D1 may contribute to development of cell cycle abnormalities, suggesting a role of Cyclin D1 in iron-related hepatocarcinogenesis.	Iron	5-9	cyclin D1	Mus musculus	122-131
16229922-12	2006	This iron-induced expression of Cyclin D1 may contribute to development of cell cycle abnormalities, suggesting a role of Cyclin D1 in iron-related hepatocarcinogenesis.	Iron	135-139	cyclin D1	Mus musculus	32-41
16229922-12	2006	This iron-induced expression of Cyclin D1 may contribute to development of cell cycle abnormalities, suggesting a role of Cyclin D1 in iron-related hepatocarcinogenesis.	Iron	135-139	cyclin D1	Mus musculus	122-131
16380292-2	2006	Now, however, a ligand-independent mechanism of IFNgammaR2 internalization is emerging as a more general way of limiting IFNgamma-STAT1 signaling in T cells, with insulin-like growth factor-1 (IGF-1) and iron as the main players.	Iron	204-208	interferon gamma receptor 2	Homo sapiens	48-58
16341090-4	2006	Incorporation of iron into the Fe/S protein Leu1 and formation of the Fe/S cluster containing holoform of the mitochondrial ferredoxin Yah1 were inhibited in the absence of Isd11.	Iron	17-21	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	44-48
16160008-2	2006	Both mk mice and Belgrade rats, which carry an identical DMT1 mutation, exhibit severe microcytic anemia at birth and defective intestinal iron use and erythroid iron use.	Iron	139-143	RoBo-1	Rattus norvegicus	57-61
16160008-2	2006	Both mk mice and Belgrade rats, which carry an identical DMT1 mutation, exhibit severe microcytic anemia at birth and defective intestinal iron use and erythroid iron use.	Iron	162-166	RoBo-1	Rattus norvegicus	57-61
16406710-1	2006	Hereditary hyperferritinemia-cataract syndrome (HHCS) is a well-characterized autosomal dominant disease caused by mutations in the iron responsive element (IRE) of ferritin L-chain (FTL) mRNA.	Iron	132-136	ferritin light chain	Homo sapiens	165-181
16406710-1	2006	Hereditary hyperferritinemia-cataract syndrome (HHCS) is a well-characterized autosomal dominant disease caused by mutations in the iron responsive element (IRE) of ferritin L-chain (FTL) mRNA.	Iron	132-136	ferritin light chain	Homo sapiens	183-186
26443573-5	2006	The mechanism of iron recycling by macrophages including iron efflux from erythrocyte-containing phagosomes, iron release from macrophages, and entry into the transferrin (Tf) cycle remain poorly understood.	Iron	17-21	transferrin	Mus musculus	159-170
26443573-8	2006	Hepcidin is induced by lipopolysaccharide (LPS) in mouse spleens and splenic macrophage in vitro and appears to mediate the LPS-induced down-regulation of ferroportin in the intestine and in splenic macrophages, suggesting that inflammatory agents may regulate iron metabolism through modulation of ferroportin expression.	Iron	261-265	hepcidin antimicrobial peptide	Mus musculus	0-8
17007103-2	2006	Using quantitative real-time PCR, we examined the expression of Hcp1 and other intestinal iron-transporting proteins in male C57BL/6 mice with experimentally altered iron homeostasis.	Iron	166-170	solute carrier family 46, member 1	Mus musculus	64-68
17007103-7	2006	A decrease in circulating hepcidin increases the expression of proteins participating in non-haem iron uptake, but has no significant effect on Hcp1 mRNA content.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	26-34
16540421-3	2006	Several PCIH analogs were shown to be effective at inducing iron mobilization and preventing iron uptake from the iron-transport protein, transferrin.	Iron	93-97	transferrin	Mus musculus	138-149
17090493-3	2006	All pretreated irons were used at 5% (wt v-1) to treat 0.014 mM (5 mgL-1) of DDT in aqueous solution.	Iron	15-20	LLGL scribble cell polarity complex component 1	Homo sapiens	67-72
16140386-9	2006	As expected, DMT-1 was increased due to Fe deprivation, but surprisingly, DMT-1 levels were also increased due to +Fe treatment, albeit not to the extent noted in ID.	Iron	40-42	RoBo-1	Rattus norvegicus	13-18
16140386-9	2006	As expected, DMT-1 was increased due to Fe deprivation, but surprisingly, DMT-1 levels were also increased due to +Fe treatment, albeit not to the extent noted in ID.	Iron	115-117	RoBo-1	Rattus norvegicus	74-79
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	114-118	RoBo-1	Rattus norvegicus	0-28
16137791-1	2005	Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells.	Iron	114-118	RoBo-1	Rattus norvegicus	30-34
16277531-3	2005	Consideration of 57Fe hyperfine coupling in S(EPR1) and lo-CO leads to a picture in which CO bridges two Fe of lo-CO, while the C2H4 of S(EPR1) binds to one of these.	Iron	19-21	baculoviral IAP repeat containing 5	Homo sapiens	46-50
15994289-6	2005	From hematopoietic stem cell transplantation and iron uptake studies in nm1054 reticulocytes, we provide evidence that the nm1054 anemia is due to an intrinsic hematopoietic defect resulting in inefficient transferrin-dependent iron uptake by erythroid precursors.	Iron	228-232	transferrin	Mus musculus	206-217
16137899-1	2005	BACKGROUND AND AIMS: While the upregulation of duodenal cytochrome b (Dcytb) within duodenal enterocytes is reported in patients with iron deficiency, the expression of hephaestin (Hp) remains controversial in altered iron metabolism states, including HFE associated hereditary hemochromatosis (HH).	Iron	134-138	cytochrome b reductase 1	Homo sapiens	47-68
16137899-1	2005	BACKGROUND AND AIMS: While the upregulation of duodenal cytochrome b (Dcytb) within duodenal enterocytes is reported in patients with iron deficiency, the expression of hephaestin (Hp) remains controversial in altered iron metabolism states, including HFE associated hereditary hemochromatosis (HH).	Iron	134-138	cytochrome b reductase 1	Homo sapiens	70-75
16140024-3	2005	Low CD8(+) lymphocyte numbers have been associated with a more severe expression of iron overload in HH patients, and in experimental models of iron overload.	Iron	84-88	CD8a molecule	Homo sapiens	4-7
16140024-3	2005	Low CD8(+) lymphocyte numbers have been associated with a more severe expression of iron overload in HH patients, and in experimental models of iron overload.	Iron	144-148	CD8a molecule	Homo sapiens	4-7
16227995-2	2005	Normal delivery of iron to developing erythroid precursors is highly dependent on the transferrin cycle.	Iron	19-23	transferrin	Mus musculus	86-97
16227996-0	2005	Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.	Iron	80-84	transferrin	Mus musculus	58-69
16227996-1	2005	The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant pathway for iron uptake by red blood cell precursors.	Iron	17-21	transferrin	Mus musculus	50-61
16227996-1	2005	The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant pathway for iron uptake by red blood cell precursors.	Iron	17-21	transferrin	Mus musculus	63-65
16227996-1	2005	The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant pathway for iron uptake by red blood cell precursors.	Iron	108-112	transferrin	Mus musculus	50-61
16227996-1	2005	The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant pathway for iron uptake by red blood cell precursors.	Iron	108-112	transferrin	Mus musculus	63-65
16227996-4	2005	Steap3 is expressed highly in hematopoietic tissues, colocalizes with the Tf cycle endosome and facilitates Tf-bound iron uptake.	Iron	117-121	STEAP family member 3	Mus musculus	0-6
16227996-4	2005	Steap3 is expressed highly in hematopoietic tissues, colocalizes with the Tf cycle endosome and facilitates Tf-bound iron uptake.	Iron	117-121	transferrin	Mus musculus	108-110
16227996-6	2005	Overexpression of Steap3 stimulates the reduction of iron, and mice lacking Steap3 are deficient in erythroid ferrireductase activity.	Iron	53-57	STEAP family member 3	Mus musculus	18-24
16227996-7	2005	Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells.	Iron	119-123	STEAP family member 3	Mus musculus	45-51
16227996-7	2005	Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells.	Iron	119-123	transferrin	Mus musculus	106-108
16244908-12	2005	Interestingly, the Fe and Mn contents were found significantly increased in AtPAP23 overexpression lines, which may offer a new direction for further functional studies of AtPAPs in Arabidopsis.	Iron	19-21	purple acid phosphatase 23	Arabidopsis thaliana	76-83
16223494-2	2005	Here, we show that growth of mutants in the Cch1pMid1p channel is markedly hypersensitive to low temperature and to high iron concentration in the medium.	Iron	121-125	Cch1p	Saccharomyces cerevisiae S288C	44-54
16153722-2	2005	Treating HT1080 cells, a human fibrosarcoma cell line, with the iron chelator 2,2-Dipyridyl, which mimics certain aspects of hypoxia, leads to a 3-fold elevated Matrix-metalloproteinase-9 (MMP-9) protein level.	Iron	64-68	matrix metallopeptidase 9	Homo sapiens	161-187
16153722-2	2005	Treating HT1080 cells, a human fibrosarcoma cell line, with the iron chelator 2,2-Dipyridyl, which mimics certain aspects of hypoxia, leads to a 3-fold elevated Matrix-metalloproteinase-9 (MMP-9) protein level.	Iron	64-68	matrix metallopeptidase 9	Homo sapiens	189-194
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Iron	192-196	neuroglobin	Homo sapiens	21-32
16201751-1	2005	Cytoglobin (Cgb) and neuroglobin (Ngb) are the first examples of hexacoordinated globins from humans and other vertebrates in which a histidine (His) residue at the sixth position of the heme iron is an endogenous ligand in both the ferric and ferrous forms.	Iron	192-196	neuroglobin	Homo sapiens	34-37
16051392-2	2005	Iron metabolism is regulated in the CNS by iron regulatory proteins (IRP-1 and IRP-2).	Iron	0-4	aconitase 1	Mus musculus	69-74
16051392-2	2005	Iron metabolism is regulated in the CNS by iron regulatory proteins (IRP-1 and IRP-2).	Iron	0-4	iron responsive element binding protein 2	Mus musculus	79-84
16051392-2	2005	Iron metabolism is regulated in the CNS by iron regulatory proteins (IRP-1 and IRP-2).	Iron	43-47	aconitase 1	Mus musculus	69-74
16051392-2	2005	Iron metabolism is regulated in the CNS by iron regulatory proteins (IRP-1 and IRP-2).	Iron	43-47	iron responsive element binding protein 2	Mus musculus	79-84
16051392-10	2005	We conclude that iron misregulation associated with the loss of IRP-2 protein affects DA regulation in the striatum.	Iron	17-21	iron responsive element binding protein 2	Mus musculus	64-69
16309565-1	2005	Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1), which oxidatively degrades heme into iron, biliverdin, and carbon monoxide (CO), or adenoviral-mediated gene transfer of HO-1 inhibits neointima formation after experimental vascular injury.	Iron	113-117	heme oxygenase 1	Rattus norvegicus	69-73
16152669-4	2005	Pathogenic bacteria invading the human host have to multiplicate under iron-restricted conditions that induce changes in the OMP composition.	Iron	71-75	olfactory marker protein	Homo sapiens	125-128
16189190-3	2005	We tested the hypothesis that a hypoxic environment and subsequent reoxygenation promote post-translational changes in the RBC protein map of newborns, in addition to desferrioxamine (DFO)-chelatable iron (DCI) release and methemoglobin (MetHb) formation.	Iron	43-47	hemoglobin subunit gamma 2	Homo sapiens	223-236
16189190-3	2005	We tested the hypothesis that a hypoxic environment and subsequent reoxygenation promote post-translational changes in the RBC protein map of newborns, in addition to desferrioxamine (DFO)-chelatable iron (DCI) release and methemoglobin (MetHb) formation.	Iron	43-47	hemoglobin subunit gamma 2	Homo sapiens	238-243
15914561-0	2005	Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading.	Iron	95-99	homeostatic iron regulator	Mus musculus	16-19
15914561-1	2005	Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver.	Iron	36-40	homeostatic iron regulator	Mus musculus	91-94
15914561-1	2005	Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver.	Iron	142-146	homeostatic iron regulator	Mus musculus	91-94
15914561-1	2005	Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver.	Iron	142-146	homeostatic iron regulator	Mus musculus	91-94
15914561-2	2005	Patients with HH and Hfe-deficient (Hfe-/-) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in response to iron loading.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	116-124
15914561-2	2005	Patients with HH and Hfe-deficient (Hfe-/-) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in response to iron loading.	Iron	181-185	hepcidin antimicrobial peptide	Mus musculus	116-124
15914561-3	2005	In this study, we investigated the contribution of Hfe expression in macrophages to the regulation of liver hepcidin levels and iron loading.	Iron	128-132	homeostatic iron regulator	Mus musculus	51-54
15914561-7	2005	Our results suggest that macrophage Hfe participates in the regulation of splenic and liver iron concentrations and liver hepcidin expression.	Iron	92-96	homeostatic iron regulator	Mus musculus	36-39
16201664-4	2005	Because the rate of hydrogen entering the iron lattice increases with PH2(1/2), and the rate of hydrogen production from corrosion, far from equilibrium conditions, is independent of PH2, at some time under closed system conditions the two rates become equal and a steady-state PH2 is attained.	Iron	42-46	polyhomeotic homolog 2	Homo sapiens	70-73
16142921-2	2005	The insertion of Ni(II) into the precursor enzyme follows the incorporation of the iron center and is the function of HypA, a Zn(II)-binding protein, and HypB, a GTPase.	Iron	83-87	hypA	Escherichia coli	118-122
15877545-13	2005	Protein expression of eNOS (endothelial NOS) and iNOS (inducible NOS), and protein nitrotyrosine formation were significantly elevated in cardiac tissue or mitochondrial extraction from the iron-deficient group.	Iron	190-194	nitric oxide synthase 3	Rattus norvegicus	28-43
15877545-14	2005	Significantly up-regulated NADPH oxidase, caveolin-1 and RhoA expression were also detected in ventricular tissue of the iron-deficient group.	Iron	121-125	ras homolog family member A	Rattus norvegicus	57-61
15754339-1	2005	epsilon-N-Trimethyllysine hydroxylase (TMLH) (EC 1.14.11.8) is a non-heme-ferrous iron hydroxylase, Fe(++) and 2-oxoglutarate (2OG) dependent, catalyzing the first of four enzymatic reactions of the highly conserved carnitine biosynthetic pathway.	Iron	100-106	trimethyllysine hydroxylase, epsilon	Homo sapiens	39-43
16155407-4	2005	The basal medium from iron chelator deferoxamine (DFO)-treated HT-29 monolayers was as chemotactic as recombinant human CCL20 at equivalent concentrations to attract CCR6(+) cells.	Iron	22-26	C-C motif chemokine receptor 6	Homo sapiens	166-170
16196900-0	2005	Spin waves in paramagnetic bcc iron: spin dynamics simulations.	Iron	31-35	spindlin 1	Homo sapiens	0-4
16196900-0	2005	Spin waves in paramagnetic bcc iron: spin dynamics simulations.	Iron	31-35	spindlin 1	Homo sapiens	37-41
16196900-1	2005	Large scale computer simulations are used to elucidate a long-standing controversy regarding the existence, or otherwise, of spin waves in paramagnetic bcc iron.	Iron	156-160	spindlin 1	Homo sapiens	125-129
15831703-4	2005	However, in the central nervous system, evidence of abnormal iron metabolism in IRP2-/- mice precedes the development of adult-onset progressive neurodegeneration, characterized by widespread axonal degeneration and neuronal loss.	Iron	61-65	iron responsive element binding protein 2	Mus musculus	80-84
15831703-5	2005	Here, we report that ablation of IRP2 results in iron-limited erythropoiesis.	Iron	49-53	iron responsive element binding protein 2	Mus musculus	33-37
16085548-1	2005	In the last few years, the field of iron metabolism has exploded with the discovery of many new proteins including ferroportin, hephaestin, hepcidin, duodenal cytochrome b and the topic of this review, divalent metal ion transporter 1 (DMT1).	Iron	36-40	hephaestin	Homo sapiens	128-138
16085548-1	2005	In the last few years, the field of iron metabolism has exploded with the discovery of many new proteins including ferroportin, hephaestin, hepcidin, duodenal cytochrome b and the topic of this review, divalent metal ion transporter 1 (DMT1).	Iron	36-40	cytochrome b reductase 1	Homo sapiens	150-171
16032772-1	2005	Site-directed mutagenesis was performed on a set of six aspartate residues of Fet3, the multicopper ferroxidase involved in high-affinity iron transport in Saccharomyces cerevisiae, in order to comprehend the molecular determinants of the protein function.	Iron	138-142	ferroxidase	Saccharomyces cerevisiae S288C	100-111
15998253-17	2005	The interaction of the CysHis site with iron provides a sensor, integrator, and effector switch coupling cathepsin B to metal-sulfuroxygen redox.	Iron	40-44	cathepsin B	Homo sapiens	105-116
15725072-1	2005	In Saccharomyces cerevisiae, the transcription factor Aft1p plays a central role in regulating many genes involved in iron acquisition and utilization.	Iron	118-122	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	54-59
15725072-3	2005	To identify the functional counterpart of AFT1 in Candida albicans, we transformed a C. albicans genomic DNA library into aft1Delta to isolate genes that could allow the mutant to grow under iron-limiting conditions.	Iron	191-195	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	42-46
16034168-0	2005	Protective effect of egg yolk phosvitin against ultraviolet- light-induced lipid peroxidation in the presence of iron ions.	Iron	113-117	casein kinase 2, beta polypeptide	Mus musculus	30-39
15951546-1	2005	BACKGROUND: Transferrin receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis.	Iron	90-94	transferrin receptor 2	Mus musculus	12-34
15951546-1	2005	BACKGROUND: Transferrin receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis.	Iron	90-94	transferrin receptor 2	Mus musculus	36-40
15951546-4	2005	AIMS: The aims of this study were to determine the phenotype and analyse expression of iron related molecules in the liver, duodenum, and spleen of homozygous TfR2-KO, heterozygous, and wild-type mice.	Iron	87-91	transferrin receptor 2	Mus musculus	159-163
15951546-8	2005	RESULTS: Homozygous TfR2-KO mice had no TfR2 protein expression and developed significant iron overload typical of TfR2 associated haemochromatosis.	Iron	90-94	transferrin receptor 2	Mus musculus	20-24
15951546-10	2005	CONCLUSIONS: Our results suggest that TfR2 is required for iron regulated expression of hepcidin and is involved in a pathway related to Hfe and hemojuvelin.	Iron	59-63	transferrin receptor 2	Mus musculus	38-42
15951546-10	2005	CONCLUSIONS: Our results suggest that TfR2 is required for iron regulated expression of hepcidin and is involved in a pathway related to Hfe and hemojuvelin.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	88-96
15713792-2	2005	To understand the mechanisms whereby hepcidin controls iron homeostasis in vivo, we have analyzed the level of iron-related proteins by Western blot and immunohistochemistry in hepcidin-deficient mice, a mouse model of severe hemochromatosis.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	37-45
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Iron	129-133	transferrin	Mus musculus	246-257
15741220-8	2005	In conclusion, our data suggest that PHD/HIF/HRE-dependent gene regulation can serve as a sensory system not only for oxygen and iron but also for copper metabolism, regulating the oxygen-, iron- and copper-binding transport proteins hemoglobin, transferrin, and ceruloplasmin, respectively.	Iron	190-194	transferrin	Mus musculus	246-257
15817488-3	2005	We show that Fet3p and Ftr1p are post-translationally regulated by iron.	Iron	67-71	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	23-28
15817488-4	2005	Incubation of cells in high iron leads to the internalization and degradation of both Fet3p and Ftr1p.	Iron	28-32	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	96-101
15817488-5	2005	Yeast strains defective in endocytosis (Deltaend4) show a reduced iron-induced loss of Fet3p-Ftr1p.	Iron	66-70	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	93-98
15817488-7	2005	Iron-induced degradation of Fet3p-Ftr1p is significantly reduced in strains containing a deletion of a gene, VTA1, which is involved in multivesicular body (MVB) sorting in yeast.	Iron	0-4	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	34-39
15817488-10	2005	Iron-induced internalization and degradation of Fet3p-Ftr1p occurs in a mutant strain of the E3 ubiquitin ligase RSP5 (rsp5-1), suggesting that Rsp5p is not required.	Iron	0-4	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	54-59
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	47-51	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	25-30
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	47-51	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	90-95
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	47-51	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	90-95
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	47-51	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	90-95
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	136-140	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	25-30
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	136-140	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	90-95
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	136-140	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	90-95
15817488-11	2005	Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex.	Iron	136-140	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	90-95
15909357-12	2005	CONCLUSIONS: The use of an algorithm including CHr to screen for iron deficiency anemia may increase the accuracy of diagnosis, enabling early detection and treatment of iron deficiency in adolescents without the need for additional costly iron studies.	Iron	65-69	chromate resistance; sulfate transport	Homo sapiens	47-50
15718038-8	2005	These data provide insight into the induction of Hfe in AD and indicate that Hfe expression may be a protective function to limit cellular iron exposure during cell stress.	Iron	139-143	homeostatic iron regulator	Mus musculus	49-52
15718038-8	2005	These data provide insight into the induction of Hfe in AD and indicate that Hfe expression may be a protective function to limit cellular iron exposure during cell stress.	Iron	139-143	homeostatic iron regulator	Mus musculus	77-80
15722349-2	2005	The amyloid precursor protein binds copper and zinc in its extracellular domain, and the Abeta peptides also bind copper, zinc, and iron.	Iron	132-136	amyloid beta precursor protein	Rattus norvegicus	4-29
15833348-3	2005	When the methionine-7 (Met-7) residue, which coordinates to the heme iron as an axial ligand, of the wild-type cytochrome b562 was replaced by an Ala or Gly residue, a water molecule bound to the heme iron and the electron transfer rate constants decreased to 1.3 x 10(-3) and 1.8 x 10(-3) cm s(-1), respectively.	Iron	69-73	mitochondrially encoded cytochrome b	Homo sapiens	111-123
15833348-3	2005	When the methionine-7 (Met-7) residue, which coordinates to the heme iron as an axial ligand, of the wild-type cytochrome b562 was replaced by an Ala or Gly residue, a water molecule bound to the heme iron and the electron transfer rate constants decreased to 1.3 x 10(-3) and 1.8 x 10(-3) cm s(-1), respectively.	Iron	201-205	mitochondrially encoded cytochrome b	Homo sapiens	111-123
16566123-2	2005	It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion.	Iron	24-28	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	134-138
16566123-2	2005	It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion.	Iron	179-183	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	134-138
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	173-177	haptoglobin	Mus musculus	147-158
15604307-3	2005	Prussian blue staining detected frequent iron deposition in the interstitium of the liver of rats treated with pressor dose ANG II for 7 days, whereas iron deposition was absent in the livers of control rats.	Iron	41-45	angiogenin	Rattus norvegicus	124-127
15604307-4	2005	Immunohistochemical and histological analyses showed that some iron-positive nonparenchymal cells were positive for ferritin and heme oxygenase-1 (HO-1) protein and TGF-beta1 mRNA and were judged to be monocytes/macrophages.	Iron	63-67	heme oxygenase 1	Rattus norvegicus	129-145
15604307-4	2005	Immunohistochemical and histological analyses showed that some iron-positive nonparenchymal cells were positive for ferritin and heme oxygenase-1 (HO-1) protein and TGF-beta1 mRNA and were judged to be monocytes/macrophages.	Iron	63-67	heme oxygenase 1	Rattus norvegicus	147-151
15819897-3	2005	Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb.	Iron	233-237	neuroglobin	Homo sapiens	72-75
15965784-1	2005	Friedreich ataxia is an autosomal recessive neurodegenerative disorder caused by a GAA trinucleotide expansion in the first intron of the Friedreich ataxia gene (FRDA) that causes reduced synthesis of frataxin, a mitochondrial protein likely to be involved in biosynthesis of iron-sulfur clusters.	Iron	276-280	frataxin	Mus musculus	138-160
15965784-1	2005	Friedreich ataxia is an autosomal recessive neurodegenerative disorder caused by a GAA trinucleotide expansion in the first intron of the Friedreich ataxia gene (FRDA) that causes reduced synthesis of frataxin, a mitochondrial protein likely to be involved in biosynthesis of iron-sulfur clusters.	Iron	276-280	frataxin	Mus musculus	162-166
15965784-1	2005	Friedreich ataxia is an autosomal recessive neurodegenerative disorder caused by a GAA trinucleotide expansion in the first intron of the Friedreich ataxia gene (FRDA) that causes reduced synthesis of frataxin, a mitochondrial protein likely to be involved in biosynthesis of iron-sulfur clusters.	Iron	276-280	frataxin	Mus musculus	201-209
15637066-2	2005	In the present study, we demonstrate that HGF stimulates epithelial cells to express neutrophil gelatinase-associated lipocalin (Ngal), a member of the lipocalin family of secreted proteins that has recently been shown to participate in mesenchymal-epithelial transformation via its ability to augment cellular iron uptake.	Iron	311-315	lipocalin 2	Homo sapiens	85-127
15637066-2	2005	In the present study, we demonstrate that HGF stimulates epithelial cells to express neutrophil gelatinase-associated lipocalin (Ngal), a member of the lipocalin family of secreted proteins that has recently been shown to participate in mesenchymal-epithelial transformation via its ability to augment cellular iron uptake.	Iron	311-315	lipocalin 2	Homo sapiens	129-133
15637066-3	2005	At concentrations below those found to mediate iron transport, purified Ngal can induce a promigratory and probranching effect that is dependent on ERK activation.	Iron	47-51	lipocalin 2	Homo sapiens	72-76
15662028-0	2005	Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo.	Iron	60-64	haptoglobin	Mus musculus	0-11
15662028-3	2005	This antioxidant function of haptoglobin is mediated in part by the ability of haptoglobin to prevent the release of iron from hemoglobin on its binding.	Iron	117-121	haptoglobin	Mus musculus	29-40
15662028-3	2005	This antioxidant function of haptoglobin is mediated in part by the ability of haptoglobin to prevent the release of iron from hemoglobin on its binding.	Iron	117-121	haptoglobin	Mus musculus	79-90
15662028-4	2005	We hypothesized that there may be diabetes- and haptoglobin genotype-dependent differences in the amount of catalytically active redox active iron derived from hemoglobin.	Iron	142-146	haptoglobin	Mus musculus	48-59
15662028-6	2005	First, measuring redox active iron associated with haptoglobin-hemoglobin complexes in vitro, we demonstrate a marked increase in redox active iron associated with Hp 2-2-glycohemoglobin complexes.	Iron	30-34	haptoglobin	Mus musculus	51-62
15662028-6	2005	First, measuring redox active iron associated with haptoglobin-hemoglobin complexes in vitro, we demonstrate a marked increase in redox active iron associated with Hp 2-2-glycohemoglobin complexes.	Iron	143-147	haptoglobin	Mus musculus	51-62
15378275-2	2005	Mice rendered iron deficient by feeding a low-iron diet for 3-4 weeks showed low levels of hepatic non-haem iron and hepcidin mRNA, with reduced urinary 5-aminolaevulinic acid (ALA) excretion and enhanced intestinal iron absorption.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	117-125
15378275-2	2005	Mice rendered iron deficient by feeding a low-iron diet for 3-4 weeks showed low levels of hepatic non-haem iron and hepcidin mRNA, with reduced urinary 5-aminolaevulinic acid (ALA) excretion and enhanced intestinal iron absorption.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	117-125
15378275-2	2005	Mice rendered iron deficient by feeding a low-iron diet for 3-4 weeks showed low levels of hepatic non-haem iron and hepcidin mRNA, with reduced urinary 5-aminolaevulinic acid (ALA) excretion and enhanced intestinal iron absorption.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	117-125
15378275-4	2005	Iron-loaded mice had markedly increased liver non-haem iron and hepcidin mRNA, with increased urinary ALA excretion.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	64-72
15522954-5	2005	Consequently, the induction of MtFt resulted in a dramatic increase in cellular iron uptake from transferrin, most of which was incorporated into MtFt.	Iron	80-84	transferrin	Mus musculus	97-108
16054057-1	2005	Ferroportin is the sole cellular efflux channel for iron and is regulated by the iron regulatory hormone hepcidin, which binds ferroportin and induces its internalization and degradation.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	105-113
16054057-1	2005	Ferroportin is the sole cellular efflux channel for iron and is regulated by the iron regulatory hormone hepcidin, which binds ferroportin and induces its internalization and degradation.	Iron	81-85	hepcidin antimicrobial peptide	Mus musculus	105-113
15611868-8	2005	Taken together, these results suggest that Sed1p mediates siderophore transport and confers iron resistance in S. cerevisiae.	Iron	92-96	Sed1p	Saccharomyces cerevisiae S288C	43-48
15713745-5	2005	We examined the effect of PEDF on kinase activity of Fyn and found that PEDF downregulated FGF-2-promoted Fyn activity by tyrosine phosphorylation at the C-terminus in a Fes-dependent manner.	Iron	170-173	Fyn proto-oncogene	Mus musculus	53-56
15713745-5	2005	We examined the effect of PEDF on kinase activity of Fyn and found that PEDF downregulated FGF-2-promoted Fyn activity by tyrosine phosphorylation at the C-terminus in a Fes-dependent manner.	Iron	170-173	Fyn proto-oncogene	Mus musculus	106-109
15713745-8	2005	In addition, wild-type Fes increased the tyrosine phosphorylation of Fyn in vitro, suggesting that Fes might directly phosphorylate Fyn.	Iron	23-26	Fyn proto-oncogene	Mus musculus	69-72
15713745-8	2005	In addition, wild-type Fes increased the tyrosine phosphorylation of Fyn in vitro, suggesting that Fes might directly phosphorylate Fyn.	Iron	23-26	Fyn proto-oncogene	Mus musculus	132-135
15711640-7	2005	The Ngal:siderophore:Fe complex upregulates heme oxygenase-1, a protective enzyme, preserves proximal tubule N-cadherin, and inhibits cell death.	Iron	21-23	cadherin 2	Mus musculus	109-119
15715653-0	2005	Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra.	Iron	78-82	solute carrier family 18 member A2	Rattus norvegicus	0-21
15754414-8	2005	PKD-induced hemolysis may cause severe iron overload even in the absence of HFE-genotype abnormalities.	Iron	39-43	protein kinase D1	Homo sapiens	0-3
15754414-10	2005	Therefore, the iron metabolism of PKD patients has to be closely monitored and iron overload should be consequently treated.	Iron	15-19	protein kinase D1	Homo sapiens	34-37
16851270-2	2005	1, 2, and 3 wt % Fe were synthesized hydrothermally using different sources of colloidal silica (HiSil and Cab-O-Sil) and characterized by ICP, XRD, N2 physisorption, UV-vis, EPR, TPR, and X-ray absorption.	Iron	17-19	translocated promoter region, nuclear basket protein	Homo sapiens	180-183
15557328-4	2005	Apart from its ability to convert citrate to iso-citrate, IRP1 in its apo-form binds to iron-responsive elements in the untranslated regions of mRNAs coding for proteins involved in iron metabolism, to regulate their synthesis and thus control the cellular homeostasis of this metal.	Iron	88-92	aconitase 1	Mus musculus	58-62
15557328-4	2005	Apart from its ability to convert citrate to iso-citrate, IRP1 in its apo-form binds to iron-responsive elements in the untranslated regions of mRNAs coding for proteins involved in iron metabolism, to regulate their synthesis and thus control the cellular homeostasis of this metal.	Iron	182-186	aconitase 1	Mus musculus	58-62
15684062-1	2005	Hepcidin is a peptide that regulates iron homeostasis by inhibiting iron absorption by the small intestine and release of iron from macrophages.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	0-8
15684062-1	2005	Hepcidin is a peptide that regulates iron homeostasis by inhibiting iron absorption by the small intestine and release of iron from macrophages.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
15684062-1	2005	Hepcidin is a peptide that regulates iron homeostasis by inhibiting iron absorption by the small intestine and release of iron from macrophages.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
15906147-3	2005	We now report that phylogenetic and relative rates analysis of a nuclear encoded catalytically active subunit of complex III, the iron-sulfur protein (ISP), shows an accelerated rate of amino acid replacement similar to cytochrome b.	Iron	130-134	mitochondrially encoded cytochrome b	Homo sapiens	220-232
15673318-1	2005	BACKGROUND: The prevalence of iron overload and the influence of mutations in the HFE and TRF2 gene on biochemical markers of iron overload among renal transplant patients is unknown.	Iron	126-130	telomeric repeat binding factor 2	Homo sapiens	90-94
15390032-1	2005	Neuroferritinopathy is a recently recognized autosomal dominant disorder that results in abnormal aggregates of iron and ferritin in the brain due to a mutation in the ferritin light chain gene on chromosome 19q13.3.	Iron	112-116	ferritin light chain	Homo sapiens	168-188
15880517-5	2005	Comparing our spin-polarized scanning tunneling spectra measured with Fe-coated W tips with spin-resolved band structure calculations, we are able to find the value of the sample surface polarization.	Iron	70-72	spindlin 1	Homo sapiens	14-18
15880517-5	2005	Comparing our spin-polarized scanning tunneling spectra measured with Fe-coated W tips with spin-resolved band structure calculations, we are able to find the value of the sample surface polarization.	Iron	70-72	spindlin 1	Homo sapiens	92-96
15698224-3	2005	The hole transmission of a Ni(81)Fe(19)/Au/Co trilayer is clearly spin dependent, resulting in a surprisingly large current change by a factor of 2.3 in a magnetic field.	Iron	33-35	spindlin 1	Homo sapiens	66-70
15621048-8	2005	Staining of serial sections of the lung tissues demonstrated induction of HO-1 co-localized to iron-stained siderophages.	Iron	95-99	heme oxygenase 1	Rattus norvegicus	74-78
15634340-2	2005	Although a relationship between the expression of ICAM-1, and classical major histocompatibility complex (MHC) class I molecules, and iron overload has been reported, no relationship has been identified between iron overload and the expression of unconventional MHC class I molecules.	Iron	134-138	intercellular adhesion molecule 1	Homo sapiens	50-56
15389541-0	2005	Mouse HFE inhibits Tf-uptake and iron accumulation but induces non-transferrin bound iron (NTBI)-uptake in transformed mouse fibroblasts.	Iron	33-37	homeostatic iron regulator	Mus musculus	6-9
15389541-0	2005	Mouse HFE inhibits Tf-uptake and iron accumulation but induces non-transferrin bound iron (NTBI)-uptake in transformed mouse fibroblasts.	Iron	85-89	homeostatic iron regulator	Mus musculus	6-9
15389541-2	2005	A non-classical class I MHC molecule, the hemochromatosis factor (HFE), has been shown to regulate iron metabolism, potentially via its interaction with the transferrin receptor.	Iron	99-103	homeostatic iron regulator	Mus musculus	66-69
15389541-7	2005	Concomitantly, cellular iron derived from transferrin-iron uptake was dramatically limited.	Iron	24-28	transferrin	Mus musculus	42-53
15389541-7	2005	Concomitantly, cellular iron derived from transferrin-iron uptake was dramatically limited.	Iron	54-58	transferrin	Mus musculus	42-53
15389541-8	2005	The activation of a non-transferrin bound iron-uptake pathway that functions in the stable mHFE-transfected clones could explain their normal growth curves and survival.	Iron	42-46	transferrin	Mus musculus	24-35
15389541-9	2005	The hypothesis that iron starvation can induce iron-uptake by a novel transferrin-independent pathway is discussed.	Iron	20-24	transferrin	Mus musculus	70-81
15389541-9	2005	The hypothesis that iron starvation can induce iron-uptake by a novel transferrin-independent pathway is discussed.	Iron	47-51	transferrin	Mus musculus	70-81
15578731-4	2005	Iron-deficient heterozygous and wild-type mice both had significantly greater plasma Tf levels (37.5 and 42.5 microM) than control mice had (heterozygous and wild-type controls were 20 and 32.5 microM) and far more than homozygous mice (&lt;0.2 microM) had, thus providing five distinct levels of plasma Tf concentrations.	Iron	0-4	transferrin	Mus musculus	85-87
15750726-4	2005	FRR3 was found to be homologous to ISU1 and ISU2 of S. cerevisiae, which form mitochondrial iron-sulfur complexes; FRR4 was found to be homologous to YFH1, the yeast frataxin homologue, which also participates in iron-sulfur cluster biogenesis.	Iron	213-217	ferroxidase	Saccharomyces cerevisiae S288C	150-154
15319276-2	2004	In this study, iron-responsive regulation of TfR2 at the protein level was examined in vitro and in vivo.	Iron	15-19	transferrin receptor 2	Mus musculus	45-49
15319276-5	2004	Hepatic TfR2 protein levels also reflected an adaptive response to changing iron status in vivo.	Iron	76-80	transferrin receptor 2	Mus musculus	8-12
15319276-6	2004	Liver TfR2 protein levels were down- and up-regulated in rats fed an iron-deficient and a high-iron diet, respectively.	Iron	69-73	transferrin receptor 2	Rattus norvegicus	6-10
15319276-7	2004	TfR2 was also up-regulated in Hfe(-/-) mice, an animal model that displays liver iron loading.	Iron	81-85	transferrin receptor 2	Mus musculus	0-4
15319276-9	2004	This idea is confirmed by up-regulation of TfR2 in beta-thalassemic mice, which, like hypotransferrinemic mice, are anemic and incur iron loading, but have functional Tf.	Iron	133-137	transferrin receptor 2	Mus musculus	43-47
15319276-10	2004	Based on these combined results, we hypothesize that TfR2 acts as a sensor of iron status such that receptor levels reflect Tf saturation.	Iron	78-82	transferrin receptor 2	Mus musculus	53-57
15507399-3	2004	Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1beta, but caused an increase in IL-6, IL-10, and TNF-alpha production.	Iron	12-16	interleukin 10	Homo sapiens	122-127
15590393-10	2004	INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes.	Iron	130-134	hemojuvelin BMP co-receptor	Mus musculus	106-109
15590393-10	2004	INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes.	Iron	130-134	hemojuvelin BMP co-receptor	Mus musculus	106-109
15590393-10	2004	INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes.	Iron	201-205	hemojuvelin BMP co-receptor	Mus musculus	47-50
15590393-10	2004	INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes.	Iron	201-205	hemojuvelin BMP co-receptor	Mus musculus	106-109
15590393-10	2004	INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes.	Iron	201-205	hemojuvelin BMP co-receptor	Mus musculus	106-109
15590393-11	2004	The wide expression of HJV as shown in the present study suggests that its role in regulating iron allocation could be extended to other tissues beyond the liver.	Iron	94-98	hemojuvelin BMP co-receptor	Mus musculus	23-26
15548115-9	2004	Our data strongly suggest that down-regulation of Betaig-h3 expression results from the defect in the TGFB1 signaling pathway and plays a pivotal role in the tumorigenic process induced by (56)Fe heavy-ion radiation.	Iron	193-195	transforming growth factor beta induced	Homo sapiens	50-59
15530098-4	2004	Room-temperature hydrogenation of alkyls 2-4 in the presence of a trapping phosphine ligand affords the iron(IV) trihydride species [PhBP(iPr)(3)]Fe(H)(3)(PR(3)) (PR(3) = PMe(3) (5); PR(3) = PEt(3) (6); PR(3) = PMePh(2) (7)).	Iron	104-108	hyaluronan binding protein 2	Homo sapiens	133-144
15251988-7	2004	Increased Ndrg1 expression following Fe chelation was related to the permeability and antiproliferative activity of chelators and could be reversed by Fe repletion.	Iron	37-39	N-myc downstream regulated 1	Homo sapiens	10-15
15472712-0	2004	Iron-induced oligomerization of yeast frataxin homologue Yfh1 is dispensable in vivo.	Iron	0-4	ferroxidase	Saccharomyces cerevisiae S288C	57-61
15472712-3	2004	Frataxin, as well as its yeast homologue Yfh1, binds multiple iron atoms as an oligomer and has been proposed to function as a crucial iron-storage protein.	Iron	62-66	ferroxidase	Saccharomyces cerevisiae S288C	41-45
15472712-4	2004	We identified a mutant Yfh1 defective in iron-induced oligomerization.	Iron	41-45	ferroxidase	Saccharomyces cerevisiae S288C	23-27
15472712-5	2004	This mutant protein was able to replace functionally wild-type Yfh1, even when expressed at low levels, when mitochondrial iron levels were high and in mutant strains having deletions of genes that had synthetic growth defects with a YFH1 deletion.	Iron	123-127	ferroxidase	Saccharomyces cerevisiae S288C	63-67
15472712-7	2004	Rather, the capacity of this oligomerization-deficient mutant to interact with the Isu protein suggests a more direct role of Yfh1 in iron-sulphur cluster biogenesis.	Iron	134-138	ferroxidase	Saccharomyces cerevisiae S288C	126-130
25175614-3	2004	This study was performed to investigate the role of metal transporters (divalent metal transporter 1, DMT1, and metal transporter protein 1, MTP1) in the lung under the environments of Fe deficiency in the body and Fe over-exposure in the lung.	Iron	185-187	RoBo-1	Rattus norvegicus	52-100
25175614-12	2004	Therefore, DMT1 and MTP1 mRNA was highly expressed in both FeD-diet and FeS-diet fed rats, after intratracheal instillation of Fe.	Iron	59-61	RoBo-1	Rattus norvegicus	11-15
15473895-1	2004	BACKGROUND: Hereditary hyperferritinaemia-cataract syndrome (HHCS) is an autosomal dominant trait associated with mutations in the iron responsive element (IRE) of the ferritin light-chain (L-ferritin) gene.	Iron	131-135	ferritin light chain	Homo sapiens	168-188
15302586-6	2004	Coexpression of a GFP-Bcr fusion protein containing the Fes binding and tyrosine phosphorylation sites (amino acids 162-413) completely suppressed neurite outgrowth triggered by Fes.	Iron	56-59	BCR activator of RhoGEF and GTPase	Rattus norvegicus	22-25
15302586-6	2004	Coexpression of a GFP-Bcr fusion protein containing the Fes binding and tyrosine phosphorylation sites (amino acids 162-413) completely suppressed neurite outgrowth triggered by Fes.	Iron	178-181	BCR activator of RhoGEF and GTPase	Rattus norvegicus	22-25
15508404-6	2004	Some vitamins (C, B2-, B3-, B6-, B12) play also a role in the metabolism of iron.	Iron	76-80	immunoglobulin kappa variable 5-2	Homo sapiens	18-36
15155457-0	2004	Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis.	Iron	21-25	homeostatic iron regulator	Mus musculus	68-71
15315790-3	2004	We report that beta2m-deficient mice, like Hfe-/- mice, lack the adaptive hepatic hepcidin mRNA increase to iron overload.	Iron	108-112	hepcidin antimicrobial peptide	Mus musculus	82-90
15315790-4	2004	The inverse correlation of hepatic iron levels and hepcidin mRNA expression in six beta2m-/- mice underlines the importance of hepcidin in regulating body iron stores.	Iron	155-159	hepcidin antimicrobial peptide	Mus musculus	127-135
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	34-38	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	207-211
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	56-60	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	207-211
15272411-2	2004	The translation initiation factor 3 (eIF3) is essential for HCV translation, and thus the effects that iron perturbations have on eIF3 expression and HCV translation were studied here.	Iron	103-107	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	130-134
15272411-5	2004	RESULTS: Iron treatment of HepG2 cells increased eIF3 mRNA and protein expression, whereas iron chelation reduced it.	Iron	9-13	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	49-53
15272411-6	2004	Accordingly, iron-dependent stimulation of eIF3 specifically induced the expression of reporter genes under the control of regulatory HCV mRNA stem-loop structures.	Iron	13-17	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	43-47
15272411-8	2004	CONCLUSION: Iron promotes the translation of HCV by stimulating the expression of eIF3, which may be one reason for the negative association between liver iron overload and HCV infection.	Iron	12-16	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	82-86
15161905-2	2004	Cells with a deletion in the vacuolar iron/manganese transporter Ccc1p are sensitive to high iron.	Iron	38-42	Ccc1p	Saccharomyces cerevisiae S288C	65-70
15161905-6	2004	We show that vacuolar iron transport is increased in Deltamrs3Deltamrs4 cells, resulting in decreased cytosolic iron and activation of the iron-sensing transcription factor Aft1p.	Iron	22-26	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	173-178
15161905-7	2004	Activation of Aft1p leads to increased expression of the high affinity iron transport system and increased iron uptake.	Iron	71-75	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	14-19
15161905-7	2004	Activation of Aft1p leads to increased expression of the high affinity iron transport system and increased iron uptake.	Iron	107-111	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	14-19
15161905-8	2004	Deletion of CCC1 in Deltamrs3Deltamrs4 cells restores cellular and mitochondrial iron homeostasis to near normal levels.	Iron	81-85	Ccc1p	Saccharomyces cerevisiae S288C	12-16
15161905-11	2004	Decreased copper resistance in Deltamrs3Deltamrs4 cells results from activation of Aft1p by Ccc1p-mediated iron depletion, as deletion of CCC1 or AFT1 in Deltamrs3Deltamrs4 cells restores copper resistance.	Iron	107-111	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	83-88
15161905-11	2004	Decreased copper resistance in Deltamrs3Deltamrs4 cells results from activation of Aft1p by Ccc1p-mediated iron depletion, as deletion of CCC1 or AFT1 in Deltamrs3Deltamrs4 cells restores copper resistance.	Iron	107-111	Ccc1p	Saccharomyces cerevisiae S288C	92-97
15300591-2	2004	By degrading heme, HO-1 generates carbon monoxide (CO), iron and biliverdin.	Iron	56-60	heme oxygenase 1	Rattus norvegicus	19-23
15270724-1	2004	Transferrin, the major plasma iron carrier, mediates iron entry into cells through interaction with its receptor.	Iron	30-34	transferrin	Mus musculus	0-11
15270724-1	2004	Transferrin, the major plasma iron carrier, mediates iron entry into cells through interaction with its receptor.	Iron	53-57	transferrin	Mus musculus	0-11
15270724-2	2004	Several in vitro studies have demonstrated that transferrin plays an essential role in lymphocyte division, a role attributed to its iron transport function.	Iron	133-137	transferrin	Mus musculus	48-59
15123701-1	2004	Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the iron regulon, including the high affinity cell-surface transport system encoded by FET3 and FTR1.	Iron	37-41	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	180-184
15123701-1	2004	Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the iron regulon, including the high affinity cell-surface transport system encoded by FET3 and FTR1.	Iron	88-92	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	180-184
15314524-4	2004	RECENT FINDINGS: The essential role of hepcidin in iron metabolism is being elucidated through mouse and human genetics, biochemistry, and cell biology.	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	39-47
15254112-7	2004	Batch experiments using equal molar concentrations of RDX and HMX demonstrated that RDX was preferentially reduced over HMX by Fe(0).	Iron	127-132	radixin	Homo sapiens	84-87
15082228-8	2004	Although, the MAO-mediated metabolism of DA increases MAO-B activity, the presence of iron inhibits both MAO-A and MAO-B activities.	Iron	86-90	monoamine oxidase B	Homo sapiens	115-120
15283633-2	2004	The hyperferritinemia-cataract syndrome, inherited as a Mendelian dominant trait, is due to mutations in the 5" non-coding region of the ferritin light chain gene that modifies the shape of the IRE (iron responsive element) region, which loses its normal function of regulating the synthesis of ferritin light chains.	Iron	199-203	ferritin light chain	Homo sapiens	137-157
15182949-4	2004	The iron chelator, ciclopirox olamine (5 microM), stimulated HIF-1alpha mRNA production under normoxic condition.	Iron	4-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	61-71
15222466-1	2004	The transferrin family of non-heme iron binding glycoproteins are believed to play a central role in iron metabolism and have been implicated in iron transport, cellular iron delivery and control of the level of free iron in external secretions.	Iron	35-39	transferrin	Mus musculus	4-15
15222466-1	2004	The transferrin family of non-heme iron binding glycoproteins are believed to play a central role in iron metabolism and have been implicated in iron transport, cellular iron delivery and control of the level of free iron in external secretions.	Iron	101-105	transferrin	Mus musculus	4-15
15222466-1	2004	The transferrin family of non-heme iron binding glycoproteins are believed to play a central role in iron metabolism and have been implicated in iron transport, cellular iron delivery and control of the level of free iron in external secretions.	Iron	101-105	transferrin	Mus musculus	4-15
15222466-1	2004	The transferrin family of non-heme iron binding glycoproteins are believed to play a central role in iron metabolism and have been implicated in iron transport, cellular iron delivery and control of the level of free iron in external secretions.	Iron	101-105	transferrin	Mus musculus	4-15
15222466-1	2004	The transferrin family of non-heme iron binding glycoproteins are believed to play a central role in iron metabolism and have been implicated in iron transport, cellular iron delivery and control of the level of free iron in external secretions.	Iron	101-105	transferrin	Mus musculus	4-15
15158278-8	2004	Finally, rFTR1 restored the ability of an ftr1 null mutant of S. cerevisiae to grow on iron-limited medium and to take up radiolabeled iron, whereas S. cerevisiae transformed with the empty vector did not.	Iron	87-91	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	42-46
15158278-8	2004	Finally, rFTR1 restored the ability of an ftr1 null mutant of S. cerevisiae to grow on iron-limited medium and to take up radiolabeled iron, whereas S. cerevisiae transformed with the empty vector did not.	Iron	135-139	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	42-46
15155653-1	2004	Neisseria meningitidis acquires iron through the action of the transferrin (Tf) receptor, which is composed of the Tf-binding proteins A and B (TbpA and TbpB).	Iron	32-36	transthyretin	Homo sapiens	144-148
15155653-5	2004	We show that TbpA is essential in both strains for iron uptake and growth with iron-loaded human Tf as a sole iron source.	Iron	51-55	transthyretin	Homo sapiens	13-17
15155653-5	2004	We show that TbpA is essential in both strains for iron uptake and growth with iron-loaded human Tf as a sole iron source.	Iron	79-83	transthyretin	Homo sapiens	13-17
15155653-5	2004	We show that TbpA is essential in both strains for iron uptake and growth with iron-loaded human Tf as a sole iron source.	Iron	79-83	transthyretin	Homo sapiens	13-17
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	106-110	homeostatic iron regulator	Mus musculus	0-3
15173932-1	2004	HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake.	Iron	106-110	transferrin	Mus musculus	31-42
15173932-5	2004	Duodenal HFE expression was positively associated with serum iron and liver HFE levels.	Iron	61-65	homeostatic iron regulator	Mus musculus	9-12
15173932-6	2004	Dietary iron supplementation decreased HFE in the duodenum but not in the liver.	Iron	8-12	homeostatic iron regulator	Mus musculus	39-42
15173932-7	2004	This was paralleled by reduced amounts of DMT-1 and FP-1 in the duodenum while the expression of DMT-1, FP-1, and hepcidin in the liver were increased with dietary iron overload.	Iron	164-168	hepcidin antimicrobial peptide	Mus musculus	114-122
15173932-8	2004	Duodenal and liver HFE levels are regulated by divergent penetration of as yet unelucidated modifier genes and to a much lesser extent by dietary iron.	Iron	146-150	homeostatic iron regulator	Mus musculus	19-22
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	32-36	homeostatic iron regulator	Mus musculus	88-91
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	186-194
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	57-61	homeostatic iron regulator	Mus musculus	88-91
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	186-194
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	57-61	homeostatic iron regulator	Mus musculus	88-91
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	186-194
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	57-61	homeostatic iron regulator	Mus musculus	88-91
15173932-9	2004	These measures control duodenal iron transport and liver iron homeostasis by modulating HFE expression either directly or via stimulation of iron sensitive regulatory molecules, such as hepcidin, which then exert their effects on body iron homeostasis.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	186-194
15259647-6	2004	The relationship between magnetic field strength and the iron normalized SAR (SAR(Fe)) is only slightly depending on the concentration of the MF and can be used for planning the target SAR.	Iron	57-61	sarcosine dehydrogenase	Homo sapiens	73-76
15259647-6	2004	The relationship between magnetic field strength and the iron normalized SAR (SAR(Fe)) is only slightly depending on the concentration of the MF and can be used for planning the target SAR.	Iron	57-61	sarcosine dehydrogenase	Homo sapiens	78-85
15259647-6	2004	The relationship between magnetic field strength and the iron normalized SAR (SAR(Fe)) is only slightly depending on the concentration of the MF and can be used for planning the target SAR.	Iron	57-61	sarcosine dehydrogenase	Homo sapiens	78-81
15064942-12	2004	iron was associated with a significant decrease in the dose of r-HuEPO (234.0 to 157.6 U/kg per week, P=0.046) and an increase of the CHr (29.2 to 30.1 pg, P=0.049), these changes were not significantly different from those experienced by patients in the oral iron group.	Iron	0-4	chromate resistance; sulfate transport	Homo sapiens	134-137
18969432-2	2004	Reason: After publication this article was discovered to have been plagiarized from an earlier work by Orlando Fatibello-Filho, Marcos Fernando de Souza Teixeira, Alexandre Zambon Pinto, presented in their paper "Coated graphite-epoxy ion-selective electrode for the determination of iron(III) in oxalic medium", published in Analytical Letters 30 (1997) 417-427.	Iron	284-288	forkhead box L2	Homo sapiens	180-185
14751922-4	2004	Hepcidin significantly reduced mucosal iron uptake and transfer to the carcass at doses of at least 10 microg/mouse per day, the reduction in transfer to the carcass being proportional to the reduction in iron uptake.	Iron	205-209	hepcidin antimicrobial peptide	Mus musculus	0-8
14751922-8	2004	Similar effects of hepcidin on iron absorption were seen in iron-deficient and Hfe knockout mice.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	19-27
14751922-9	2004	Hepcidin inhibited the uptake step of duodenal iron absorption but did not affect the proportion of iron transferred to the circulation.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	0-8
14751922-11	2004	The data support a key role for hepcidin in the regulation of intestinal iron uptake.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	32-40
15028670-1	2004	Friedreich ataxia (FRDA), a progressive neurodegenerative disorder associated with cardiomyopathy, is caused by severely reduced frataxin, a mitochondrial protein involved in Fe-S cluster assembly.	Iron	175-177	frataxin	Mus musculus	0-24
15028670-1	2004	Friedreich ataxia (FRDA), a progressive neurodegenerative disorder associated with cardiomyopathy, is caused by severely reduced frataxin, a mitochondrial protein involved in Fe-S cluster assembly.	Iron	175-177	frataxin	Mus musculus	129-137
15028670-3	2004	Our frataxin-deficient mouse models initially demonstrate time-dependent intramitochondrial iron accumulation, which occurs after onset of the pathology and after inactivation of the Fe-S dependent enzymes.	Iron	92-96	frataxin	Mus musculus	4-12
15028670-3	2004	Our frataxin-deficient mouse models initially demonstrate time-dependent intramitochondrial iron accumulation, which occurs after onset of the pathology and after inactivation of the Fe-S dependent enzymes.	Iron	183-187	frataxin	Mus musculus	4-12
15028670-8	2004	Our results support the view that frataxin is a necessary, albeit non-essential, component of the Fe-S cluster biogenesis, and indicate that Idebenone acts downstream of the primary Fe-S enzyme deficit.	Iron	98-102	frataxin	Mus musculus	34-42
15028670-8	2004	Our results support the view that frataxin is a necessary, albeit non-essential, component of the Fe-S cluster biogenesis, and indicate that Idebenone acts downstream of the primary Fe-S enzyme deficit.	Iron	98-100	frataxin	Mus musculus	34-42
15274393-5	2004	RESULTS: Patients with Ki-ras mutations in codon 12 (K12) consumed significantly less vitamin A (p=0.02), B1 (p=0.01), D (p=0.02) and iron (p=0.03) than controls, whereas patients without these mutations had similar intakes of these nutrients to controls.	Iron	134-138	KRAS proto-oncogene, GTPase	Homo sapiens	23-29
14997284-12	2004	ornithine decarboxylase activity and [(3)H]thymidine incorporation into cutaneous DNA, was about 60% lower in TPA-treated mice fed on low iron diet than in normal mice treated with TPA.	Iron	138-142	ornithine decarboxylase, structural 1	Mus musculus	0-23
15098034-5	2004	Hepcidin antimicrobial peptide (Hamp) is a hepatic defensin-like peptide hormone that inhibits duodenal iron absorption and macrophage iron release.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	0-30
15098034-5	2004	Hepcidin antimicrobial peptide (Hamp) is a hepatic defensin-like peptide hormone that inhibits duodenal iron absorption and macrophage iron release.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	32-36
15098034-5	2004	Hepcidin antimicrobial peptide (Hamp) is a hepatic defensin-like peptide hormone that inhibits duodenal iron absorption and macrophage iron release.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	0-30
15098034-5	2004	Hepcidin antimicrobial peptide (Hamp) is a hepatic defensin-like peptide hormone that inhibits duodenal iron absorption and macrophage iron release.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	32-36
15098034-6	2004	Hamp is part of the type II acute phase response and is thought to have a crucial regulatory role in sequestering iron in the context of ACD.	Iron	114-118	hepcidin antimicrobial peptide	Mus musculus	0-4
14701678-8	2004	Iron binding assays with rat adrenal cortex extracts further identified a 90-kDa melanotransferrin immunoreactive protein binding iron, suggesting that the identified protein, which we name "adrenotransferrin," may have iron-binding activity.	Iron	0-4	melanotransferrin	Rattus norvegicus	81-98
14701678-8	2004	Iron binding assays with rat adrenal cortex extracts further identified a 90-kDa melanotransferrin immunoreactive protein binding iron, suggesting that the identified protein, which we name "adrenotransferrin," may have iron-binding activity.	Iron	130-134	melanotransferrin	Rattus norvegicus	81-98
15084469-7	2004	Delayed upregulation of the negative hormonal regulator of iron homeostasis, hepcidin (Hamp), during postnatal development correlates strongly with profound increases in Fpn1 protein levels and polycythemia in Pcm heterozygotes.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	77-85
15084469-7	2004	Delayed upregulation of the negative hormonal regulator of iron homeostasis, hepcidin (Hamp), during postnatal development correlates strongly with profound increases in Fpn1 protein levels and polycythemia in Pcm heterozygotes.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	87-91
15084469-8	2004	Thus, our data suggest that a Hamp-mediated regulatory interference alleviates the defects in iron homeostasis and transient alterations in erythropoiesis caused by a regulatory mutation in Fpn1.	Iron	94-98	hepcidin antimicrobial peptide	Mus musculus	30-34
15075239-5	2004	In contrast, iron chelators induced VEGF but not RBM3 or CIRP.	Iron	13-17	vascular endothelial growth factor A	Mus musculus	36-40
14630809-4	2004	Hepcidin is a hepatic antimicrobial-like peptide whose role in iron homeostasis was first defined in animal models; deficiency of hepcidin in mice leads to iron overload, whereas its hepatic overexpression in transgenic animals causes iron deficiency.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	0-8
14630809-4	2004	Hepcidin is a hepatic antimicrobial-like peptide whose role in iron homeostasis was first defined in animal models; deficiency of hepcidin in mice leads to iron overload, whereas its hepatic overexpression in transgenic animals causes iron deficiency.	Iron	156-160	hepcidin antimicrobial peptide	Mus musculus	0-8
14576080-0	2004	Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase.	Iron	22-26	chemokine (C-C motif) ligand 2	Mus musculus	62-67
14576080-5	2004	In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation.	Iron	17-21	chemokine (C-C motif) ligand 2	Mus musculus	171-176
15105272-8	2004	Mice with a targeted disruption of a gene for iron regulatory protein 2 (IRP2), a translational repressor of ferritin, misregulate iron metabolism in the intestinal mucosa and the central nervous system.	Iron	46-50	iron responsive element binding protein 2	Mus musculus	73-77
14629196-6	2004	Siderophore uptake from different sources was also increased, and these effects were dependent on the AFT1 iron sensor regulator.	Iron	107-111	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	102-106
14704719-1	2004	Recent studies in lymphohemopoietic cells show that transferrin (Tf), a pivotal component of iron transport and metabolism, also exerts cytoprotective functions.	Iron	93-97	transferrin	Mus musculus	52-63
14704719-1	2004	Recent studies in lymphohemopoietic cells show that transferrin (Tf), a pivotal component of iron transport and metabolism, also exerts cytoprotective functions.	Iron	93-97	transferrin	Mus musculus	65-67
14704719-4	2004	The results obtained with iron-saturated Tf, Apo-Tf and the iron-chelator salicylaldehyde isonicotinoyl hydrazone indicate that the observed antiapoptotic effect of Tf was not mediated by iron alone.	Iron	26-30	transferrin	Mus musculus	41-43
14759599-11	2004	Protonation of His-64 in Mb enhances HN3 binding due to a gating mechanism while protonation of His-52 in CcP decreases the affinity for HN3 due to loss of base-assisted association of the ligand to the heme iron.	Iron	208-212	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	106-109
14534306-5	2004	New or additional support for a role in copper and iron homeostasis is provided in this study for the gene products of AKR1, MRS4, PCA1, SSU1, TIS11, YBR047W, YHL035C, YHR045W, YLR047C, YLR126C, and YTP1.	Iron	51-55	Ytp1p	Saccharomyces cerevisiae S288C	199-203
14707007-4	2004	In the presence of 0.1% FBS media, hemin induced p21 through an HO-dependent, p53-independent mechanism; certain products of HO activity (iron and carbon monoxide), but not others (ferritin, apoferritin, bilirubin), recapitulated these inductive effects on p21 expression.	Iron	138-142	KRAS proto-oncogene, GTPase	Rattus norvegicus	49-52
15019542-0	2004	Is blood donation induced low iron status associated with favourable levels of OxLDL, s-ICAM-1, sVCAM-1 and vWF-antigen in healthy men.	Iron	30-34	intercellular adhesion molecule 1	Homo sapiens	88-94
12748861-5	2004	Furthermore, members of the ZIP family have been implicated in the transport of zinc, iron, and/or manganese indicating that these proteins have diverse functions.	Iron	86-90	death associated protein kinase 3	Homo sapiens	28-31
14736998-5	2004	Cells treated with the iron chelator deferoxamine displayed higher levels of the iron transporter divalent metal transporter 1 (DMT1) mRNA and protein, and consistent with increased DMT1 expression, the treated cells displayed greater uptake of Pb in the buffer at pH 5.5 but not at pH 7.4.	Iron	23-27	RoBo-1	Rattus norvegicus	128-132
14736998-5	2004	Cells treated with the iron chelator deferoxamine displayed higher levels of the iron transporter divalent metal transporter 1 (DMT1) mRNA and protein, and consistent with increased DMT1 expression, the treated cells displayed greater uptake of Pb in the buffer at pH 5.5 but not at pH 7.4.	Iron	23-27	RoBo-1	Rattus norvegicus	182-186
14741370-0	2004	Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae.	Iron	70-74	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	59-64
14741370-2	2004	The present work demonstrates that in vivo yeast frataxin Yfh1p and Isu1p, the mitochondrial scaffold protein for the Fe-S cluster assembly, have tightly linked biological functions, acting in concert to promote the Fe-S cluster assembly.	Iron	118-120	ferroxidase	Saccharomyces cerevisiae S288C	58-63
14741370-2	2004	The present work demonstrates that in vivo yeast frataxin Yfh1p and Isu1p, the mitochondrial scaffold protein for the Fe-S cluster assembly, have tightly linked biological functions, acting in concert to promote the Fe-S cluster assembly.	Iron	118-120	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	68-73
14741370-2	2004	The present work demonstrates that in vivo yeast frataxin Yfh1p and Isu1p, the mitochondrial scaffold protein for the Fe-S cluster assembly, have tightly linked biological functions, acting in concert to promote the Fe-S cluster assembly.	Iron	216-218	ferroxidase	Saccharomyces cerevisiae S288C	58-63
14741370-2	2004	The present work demonstrates that in vivo yeast frataxin Yfh1p and Isu1p, the mitochondrial scaffold protein for the Fe-S cluster assembly, have tightly linked biological functions, acting in concert to promote the Fe-S cluster assembly.	Iron	216-218	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	68-73
15570302-2	2004	The risk of iron accumulation in pyruvate kinase deficiency (PKD) has traditionally been regarded as low, but recent evidence has questioned this notion.	Iron	12-16	protein kinase D1	Homo sapiens	61-64
15570302-3	2004	We here present a case of a young PKD patient showing evidence of asymptomatic iron accumulation measured as liver iron concentration (LIC) obtained noninvasively by magnetic resonance imaging.	Iron	79-83	protein kinase D1	Homo sapiens	34-37
15570302-3	2004	We here present a case of a young PKD patient showing evidence of asymptomatic iron accumulation measured as liver iron concentration (LIC) obtained noninvasively by magnetic resonance imaging.	Iron	115-119	protein kinase D1	Homo sapiens	34-37
15570302-5	2004	The iron status of PKD patients, preferably assessed by LIC measurements, should therefore be evaluated regularly also in asymptomatic patients.	Iron	4-8	protein kinase D1	Homo sapiens	19-22
14675249-8	2004	We found a significantly higher number of GFAP and alpha-SMA positive cells in patients with liver iron deposits compared with those without iron deposits, and a positive correlation between liver iron scores and number (%) of GFAP and alpha-SMA positive cells.	Iron	99-103	glial fibrillary acidic protein	Homo sapiens	42-46
14618243-0	2004	Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin.	Iron	0-4	homeostatic iron regulator	Mus musculus	23-26
14618243-2	2004	It has been hypothesized that mutations in the HH gene HFE cause misprogramming of the duodenal enterocytes towards a paradoxical iron-deficient state, resulting in increased iron transporter expression.	Iron	130-134	homeostatic iron regulator	Mus musculus	55-58
14754084-2	2003	The spin asymmetry in the SP of He(*) scattered from a clean Fe/Cu(100) surface changed its polarity with H2O adsorption.	Iron	61-63	spindlin 1	Homo sapiens	4-8
14677976-2	2003	To assign the observed signals to specific nuclei, bis-imidazol coordinated heme compounds that model the iron environment in cytochrome b(559) are also studied.	Iron	106-110	mitochondrially encoded cytochrome b	Homo sapiens	126-138
14522963-9	2003	Similar results were also obtained from myeloperoxidase knockout mice exposed to the iron complex, suggesting that the myeloperoxidase-catalyzed oxidation system might not be essential for the generation of acrolein in this experimental animal carcinogenesis model.	Iron	85-89	myeloperoxidase	Mus musculus	40-55
14522963-9	2003	Similar results were also obtained from myeloperoxidase knockout mice exposed to the iron complex, suggesting that the myeloperoxidase-catalyzed oxidation system might not be essential for the generation of acrolein in this experimental animal carcinogenesis model.	Iron	85-89	myeloperoxidase	Mus musculus	119-134
14523005-0	2003	Pse1p mediates the nuclear import of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.	Iron	41-45	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	78-83
14523005-1	2003	In Saccharomyces cerevisiae, the iron-responsive transcription factor Aft1p plays a critical role in maintaining iron homeostasis.	Iron	33-37	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	70-75
14523005-1	2003	In Saccharomyces cerevisiae, the iron-responsive transcription factor Aft1p plays a critical role in maintaining iron homeostasis.	Iron	113-117	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	70-75
14523005-2	2003	The activity of Aft1p is induced in response to iron starvation and as a consequence the expression of the iron-regulon is increased.	Iron	48-52	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	16-21
14523005-2	2003	The activity of Aft1p is induced in response to iron starvation and as a consequence the expression of the iron-regulon is increased.	Iron	107-111	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	16-21
14523005-3	2003	We have shown previously that Aft1p is localized to the cytoplasm under iron-replete conditions but that it is localized to the nucleus under iron-depleted conditions.	Iron	72-76	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	30-35
14523005-3	2003	We have shown previously that Aft1p is localized to the cytoplasm under iron-replete conditions but that it is localized to the nucleus under iron-depleted conditions.	Iron	142-146	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	30-35
14523005-5	2003	In pse1-1 cells, which bear a temperature-sensitive mutation of PSE1, Aft1p was misdirected to the cytoplasm during iron starvation at the restrictive temperature.	Iron	116-120	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	70-75
12958019-0	2003	DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption.	Iron	69-73	RoBo-1	Rattus norvegicus	0-4
14754321-0	2003	Radiative opacities and configuration interaction effects of hot iron plasma using a detailed term accounting model.	Iron	65-69	alcohol dehydrogenase iron containing 1	Homo sapiens	61-64
12972424-4	2003	We show that Drosophila iron regulatory protein-1 (IRP1) registers cytosolic iron and oxidative stress through its labile iron sulfur cluster by switching between cytosolic aconitase and RNA-binding functions.	Iron	24-28	Iron regulatory protein 1A	Drosophila melanogaster	51-55
12972424-4	2003	We show that Drosophila iron regulatory protein-1 (IRP1) registers cytosolic iron and oxidative stress through its labile iron sulfur cluster by switching between cytosolic aconitase and RNA-binding functions.	Iron	24-28	Iron regulatory protein 1A	Drosophila melanogaster	163-182
12960168-3	2003	These genes, FET3, FTR1, TIS11, SIT1, and FIT2, are involved in the iron uptake pathway.	Iron	68-72	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	19-23
12960168-5	2003	The transcriptional factor Aft1p, which is known to control their induction in response to iron limitation, is also required for their induction during the diauxic shift.	Iron	91-95	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	27-32
12960168-9	2003	Thus, the two signals, glucose exhaustion and iron starvation, use two independent pathways to activate the same set of genes through the Aft1p transcriptional factor.	Iron	46-50	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	138-143
14551810-0	2003	Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp: exogenous anion influence and comparison with mammalian transferrin.	Iron	26-30	programmed cell death 11	Homo sapiens	81-85
14551810-9	2003	Significantly, we address the lability of the Fe(3+) coordination shell in nFbp, Fe(3+) nFbp(X) (X=PO(4)(3-), citrate), with respect to exogenous anion (X(n-)) exchange and dissociation, and ultimately complete dissociation of the protein to yield naked (hydrated) Fe(aq)(3+).	Iron	46-48	programmed cell death 11	Homo sapiens	75-79
14551810-9	2003	Significantly, we address the lability of the Fe(3+) coordination shell in nFbp, Fe(3+) nFbp(X) (X=PO(4)(3-), citrate), with respect to exogenous anion (X(n-)) exchange and dissociation, and ultimately complete dissociation of the protein to yield naked (hydrated) Fe(aq)(3+).	Iron	46-48	programmed cell death 11	Homo sapiens	88-92
14531808-1	2003	BACKGROUND: We have previously shown that the rat kidney reabsorbs metabolically significant amounts of iron and that it expresses the divalent metal transporter 1, DMT1.	Iron	104-108	RoBo-1	Rattus norvegicus	165-169
14531808-2	2003	The Belgrade (b) rat carries a mutation in DMT1 gene, which causes hypochromic, microcytic anemia due to impaired intestinal iron absorption and transport of iron out of the transferrin cycle endosome.	Iron	125-129	RoBo-1	Rattus norvegicus	43-47
14531808-3	2003	In the duodenum of b/b rats, expression of DMT1 mRNA and protein is increased, suggesting a feedback regulation by iron stores.	Iron	115-119	RoBo-1	Rattus norvegicus	43-47
14526117-2	2003	Here, we report that FRO2 and IRT1, the major transporter responsible for high-affinity iron uptake from the soil, are coordinately regulated at both the transcriptional and posttranscriptional levels.	Iron	88-92	iron-regulated transporter 1	Arabidopsis thaliana	30-34
14526117-3	2003	FRO2 and IRT1 are induced together following the imposition of iron starvation and are coordinately repressed following iron resupply.	Iron	63-67	iron-regulated transporter 1	Arabidopsis thaliana	9-13
14526117-3	2003	FRO2 and IRT1 are induced together following the imposition of iron starvation and are coordinately repressed following iron resupply.	Iron	120-124	iron-regulated transporter 1	Arabidopsis thaliana	9-13
14550302-1	2003	Yeast strain deleted for the YFH1 gene, which encodes the orthologue of human frataxin, accumulates iron in mitochondria, constitutively activates the high-affinity iron import system in the plasma membrane, and is sensitive to high iron media.	Iron	100-104	ferroxidase	Saccharomyces cerevisiae S288C	29-33
14550302-1	2003	Yeast strain deleted for the YFH1 gene, which encodes the orthologue of human frataxin, accumulates iron in mitochondria, constitutively activates the high-affinity iron import system in the plasma membrane, and is sensitive to high iron media.	Iron	165-169	ferroxidase	Saccharomyces cerevisiae S288C	29-33
14550302-1	2003	Yeast strain deleted for the YFH1 gene, which encodes the orthologue of human frataxin, accumulates iron in mitochondria, constitutively activates the high-affinity iron import system in the plasma membrane, and is sensitive to high iron media.	Iron	165-169	ferroxidase	Saccharomyces cerevisiae S288C	29-33
14550302-2	2003	We have performed a genetic screen for mutants of a yfh1 deleted strain with increased resistance to high levels of iron.	Iron	116-120	ferroxidase	Saccharomyces cerevisiae S288C	52-56
12805055-6	2003	DOX-induced iron metabolism changes were intensified in Hfe-/- mice, which accumulated significantly more iron in the heart, liver, and pancreas, but less in the spleen compared with wild-type mice.	Iron	12-16	homeostatic iron regulator	Mus musculus	56-59
12805055-6	2003	DOX-induced iron metabolism changes were intensified in Hfe-/- mice, which accumulated significantly more iron in the heart, liver, and pancreas, but less in the spleen compared with wild-type mice.	Iron	106-110	homeostatic iron regulator	Mus musculus	56-59
12805055-9	2003	DOX-treated Hfe-/- mice had a higher degree of mitochondrial damage and iron deposits in the heart than did wild-type mice.	Iron	72-76	homeostatic iron regulator	Mus musculus	12-15
14564671-1	2003	Recently discovered peptide-hepcidin (Hepc) may be a central player in the communication of iron body stores to the intestinal absorptive cells and thus involved in the maintenance of iron homeostasis.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	28-36
14564671-1	2003	Recently discovered peptide-hepcidin (Hepc) may be a central player in the communication of iron body stores to the intestinal absorptive cells and thus involved in the maintenance of iron homeostasis.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	38-42
14564671-1	2003	Recently discovered peptide-hepcidin (Hepc) may be a central player in the communication of iron body stores to the intestinal absorptive cells and thus involved in the maintenance of iron homeostasis.	Iron	184-188	hepcidin antimicrobial peptide	Mus musculus	28-36
14564671-1	2003	Recently discovered peptide-hepcidin (Hepc) may be a central player in the communication of iron body stores to the intestinal absorptive cells and thus involved in the maintenance of iron homeostasis.	Iron	184-188	hepcidin antimicrobial peptide	Mus musculus	38-42
14564671-2	2003	The aim of this study was to determine the effects of the level of dietary iron on Hepc gene expression in the liver.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	83-87
14564671-4	2003	Results clearly showed that Hepc gene expression is upregulated by high dietary iron and downregulated when the dietary iron level is low.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	28-32
14564671-4	2003	Results clearly showed that Hepc gene expression is upregulated by high dietary iron and downregulated when the dietary iron level is low.	Iron	120-124	hepcidin antimicrobial peptide	Mus musculus	28-32
14564671-5	2003	Both Hepc 1 and Hepc 2 expression responds coordinately to dietary iron.	Iron	67-71	hepcidin antimicrobial peptide	Mus musculus	5-11
14564671-6	2003	This work provides additional evidence of the key role of Hepc in the regulation of iron homeostasis.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	58-62
14499595-6	2003	In hypotransferrinaemic (hpx) mice, sdr2 expression in the liver and kidney is reduced, suggesting that it may be regulated by iron.	Iron	127-131	uncharacterized protein	Drosophila melanogaster	36-40
12970193-3	2003	Depletion of the cysteine desulfurase Nfs1p, the ferredoxin Yah1p or the yeast frataxin homologue Yfh1p by regulated gene expression causes a strong decrease in the de novo synthesis of Fe/S clusters on Isu1p.	Iron	186-188	ferroxidase	Saccharomyces cerevisiae S288C	98-103
12970193-3	2003	Depletion of the cysteine desulfurase Nfs1p, the ferredoxin Yah1p or the yeast frataxin homologue Yfh1p by regulated gene expression causes a strong decrease in the de novo synthesis of Fe/S clusters on Isu1p.	Iron	186-188	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	203-208
12970193-4	2003	In contrast, depletion of the Hsp70 chaperone Ssq1p, its co-chaperone Jac1p or the glutaredoxin Grx5p markedly increased the amount of Fe/S clusters bound to Isu1p, even though these mitochondrial proteins are crucial for maturation of Fe/S proteins.	Iron	135-137	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	70-75
12970193-4	2003	In contrast, depletion of the Hsp70 chaperone Ssq1p, its co-chaperone Jac1p or the glutaredoxin Grx5p markedly increased the amount of Fe/S clusters bound to Isu1p, even though these mitochondrial proteins are crucial for maturation of Fe/S proteins.	Iron	135-137	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	158-163
14614257-4	2003	Similarly, MBP concentrations were also reduced (25-35%) in all three groups of iron-deficient animals.	Iron	80-84	myelin basic protein	Rattus norvegicus	11-14
12947415-2	2003	The function of frataxin is unclear, although recent studies have suggested a function of frataxin (yeast Yfh1) in iron/sulphur (Fe/S) protein biogenesis.	Iron	115-119	ferroxidase	Saccharomyces cerevisiae S288C	106-110
12947415-4	2003	Association between Yfh1 and Isu1/Nfs1 was markedly increased by ferrous iron, but did not depend on ISCs on Isu1.	Iron	73-77	ferroxidase	Saccharomyces cerevisiae S288C	20-24
12947415-4	2003	Association between Yfh1 and Isu1/Nfs1 was markedly increased by ferrous iron, but did not depend on ISCs on Isu1.	Iron	73-77	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	29-33
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	4-8	ferroxidase	Saccharomyces cerevisiae S288C	30-34
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	4-8	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	38-42
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	4-8	ferroxidase	Saccharomyces cerevisiae S288C	76-80
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	84-88	ferroxidase	Saccharomyces cerevisiae S288C	30-34
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	84-88	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	38-42
12947415-7	2003	The iron-dependent binding of Yfh1 to Isu1/Nfs1 suggests a role of frataxin/Yfh1 in iron loading of the Isu scaffold proteins.	Iron	84-88	ferroxidase	Saccharomyces cerevisiae S288C	76-80
12796496-0	2003	Biophysical and structural analysis of a novel heme B iron ligation in the flavocytochrome cellobiose dehydrogenase.	Iron	54-58	choline dehydrogenase	Homo sapiens	91-115
12794075-0	2003	Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate.	Iron	69-73	heme oxygenase 1	Rattus norvegicus	25-41
12893266-8	2003	Additionally, the axial ligand rings counterclockwise rotate around His39 N-Fe axis due to the mutation, which is confirmed by variation of the hyperfine shifts of the heme protons of V61H compared to those of WT cytochrome b(5).	Iron	76-78	cytochrome b	Bos taurus	213-225
12832620-8	2003	These mutants thus provide unique models for exploring how the endocytic function of mouse Picalm and the transport processes mediated by clathrin and the AP2 complex contribute to normal hematopoiesis, iron metabolism, and growth.	Iron	203-207	phosphatidylinositol binding clathrin assembly protein	Mus musculus	91-97
12704186-0	2003	Azide and acetate complexes plus two iron-depleted crystal structures of the di-iron enzyme delta9 stearoyl-acyl carrier protein desaturase.	Iron	37-41	stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic	Ricinus communis	92-139
12832761-1	2003	The molybdenum- and iron-containing enzyme sulfite oxidase catalyzes the physiologically vital oxidation of sulfite to sulfate.	Iron	20-24	sulfite oxidase	Homo sapiens	43-58
12819036-12	2003	Fe-induced injury suppressed HK-2 cell SR-B1, ABCA-1, and their mRNAs.	Iron	0-2	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	46-52
12819036-13	2003	LDL-R protein rose with the in vitro Fe challenge.	Iron	37-39	low density lipoprotein receptor	Mus musculus	0-5
12684851-2	2003	Fet3p catalyzes the oxidation of Fe(2+) to Fe(3+); this ferroxidation reaction is an obligatory first step in high-affinity iron uptake through the permease Ftr1p.	Iron	124-128	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	157-162
12767048-3	2003	The understanding of the role of DMT1 in heart iron metabolism is fundamental for elucidating the cause resulting in excessive iron in the heart.	Iron	47-51	RoBo-1	Rattus norvegicus	33-37
12767048-3	2003	The understanding of the role of DMT1 in heart iron metabolism is fundamental for elucidating the cause resulting in excessive iron in the heart.	Iron	127-131	RoBo-1	Rattus norvegicus	33-37
12767048-4	2003	The study was to evaluate effects of age and dietary iron on DMT1 mRNA expression and protein synthesis in rat heart.	Iron	53-57	RoBo-1	Rattus norvegicus	61-65
12767048-8	2003	During different ages, the levels of DMT1 (IRE) mRNA were higher than those of DMT1 (non-IRE) mRNA and were significantly correlated with the non-heme iron contents in the heart.	Iron	151-155	RoBo-1	Rattus norvegicus	37-41
12767048-9	2003	After fed a high iron for 6 weeks, the rats had a sixfold elevation in heart iron and 22% (non-IRE from) and 40% (IRE from) reduction in DMT1 protein compared to the controls.	Iron	17-21	RoBo-1	Rattus norvegicus	137-141
12767048-10	2003	A low iron diet for 6-weeks caused cardiac hypertrophy and heart iron deficiency and also an increase in levels of two forms of DMT1 proteins.	Iron	6-10	RoBo-1	Rattus norvegicus	128-132
12767048-12	2003	The results demonstrated that DMT1 mRNAs expression in the heart is age-dependent and that two forms of DMT1 mRNAs both are regulated by iron on the post-transcriptional level only.	Iron	137-141	RoBo-1	Rattus norvegicus	104-108
12750309-6	2003	The hearts of the HFE knockout mice showed increased iron deposition, increased content of reactive oxygen species (ROS) as evidenced by the increased formation of malondialdehyde, and reduced antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase.	Iron	53-57	homeostatic iron regulator	Mus musculus	18-21
12750309-7	2003	The results suggest that increased amount of ROS and reduced antioxidant reserve secondary to iron overloading may be instrumental for the susceptibility of the HFE gene knockout mice to cardiac injury.	Iron	94-98	homeostatic iron regulator	Mus musculus	161-164
12749023-12	2003	Our findings indicate that, besides its known iron transport function, Tf is able to influence myelination process and induce behavioral improvements in mice.	Iron	46-50	transferrin	Mus musculus	71-73
12787249-3	2003	A previous study showed that AtNRAMP3 expression is upregulated by iron (Fe) starvation and that AtNRAMP3 protein can transport Fe.	Iron	67-71	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	29-37
12787249-3	2003	A previous study showed that AtNRAMP3 expression is upregulated by iron (Fe) starvation and that AtNRAMP3 protein can transport Fe.	Iron	73-75	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	29-37
12787249-3	2003	A previous study showed that AtNRAMP3 expression is upregulated by iron (Fe) starvation and that AtNRAMP3 protein can transport Fe.	Iron	73-75	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	97-105
12787249-3	2003	A previous study showed that AtNRAMP3 expression is upregulated by iron (Fe) starvation and that AtNRAMP3 protein can transport Fe.	Iron	128-130	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	29-37
12787249-3	2003	A previous study showed that AtNRAMP3 expression is upregulated by iron (Fe) starvation and that AtNRAMP3 protein can transport Fe.	Iron	128-130	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	97-105
12787249-4	2003	In the present study, we used AtNRAMP3 promoter beta-glucoronidase (GUS) fusions to show that AtNRAMP3 is expressed in the vascular bundles of roots, stems, and leaves under Fe-sufficient conditions.	Iron	174-176	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	94-102
12787249-6	2003	Under Fe-starvation conditions, the GUS activity driven by the AtNRAMP3 promoter is upregulated without any change in the expression pattern.	Iron	6-8	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	63-71
12787249-8	2003	Under Fe-sufficient conditions, AtNRAMP3 overexpression or disruption does not lead to any change in the plant metal content.	Iron	6-8	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	32-40
12787249-9	2003	Upon Fe starvation, AtNRAMP3 disruption leads to increased accumulation of manganese (Mn) and zinc (Zn) in the roots, whereas AtNRAMP3 overexpression downregulates Mn accumulation.	Iron	5-7	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	20-28
12729891-1	2003	In contrast to the human genome, the mouse genome contains two HEPC genes encoding hepcidin, a key regulator of iron homeostasis.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	63-67
12729891-1	2003	In contrast to the human genome, the mouse genome contains two HEPC genes encoding hepcidin, a key regulator of iron homeostasis.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	83-91
12729891-2	2003	Here we report a comparative analysis of sequence, genomic structure, expression and iron regulation of mouse HEPC genes.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	110-114
12729891-9	2003	Overall our data suggest that both HEPC1 and HEPC2 genes are involved in iron metabolism regulation but could exhibit different activities and/or play distinct roles.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	35-40
12756430-1	2003	Methemoglobinemia, an increased concentration of methemoglobin in the blood, is an altered state of hemoglobin whereby the ferrous form of iron is oxidized to the ferric state, rendering the heme moiety incapable of carrying oxygen.	Iron	139-143	hemoglobin subunit gamma 2	Homo sapiens	49-62
12704388-0	2003	Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	13-21
12704388-4	2003	Mice lacking Hfe or producing a C282Y mutant Hfe protein develop hyperferremia and have high hepatic iron levels.	Iron	101-105	homeostatic iron regulator	Mus musculus	45-48
12704388-6	2003	It has been suggested that HFE modulates uptake of transferrin-bound iron by undifferentiated intestinal crypt cells, thereby programming the absorptive capacity of enterocytes derived from these cells; however, this model is unproven and controversial.	Iron	69-73	homeostatic iron regulator	Mus musculus	27-30
12704388-6	2003	It has been suggested that HFE modulates uptake of transferrin-bound iron by undifferentiated intestinal crypt cells, thereby programming the absorptive capacity of enterocytes derived from these cells; however, this model is unproven and controversial.	Iron	69-73	transferrin	Mus musculus	51-62
12704388-8	2003	Although expression of mouse Hamp is normally greater during iron overload, Hfe-/- mice have inappropriately low expression of Hamp.	Iron	61-65	hepcidin antimicrobial peptide	Mus musculus	29-33
12704388-9	2003	We crossed Hfe-/- mice with transgenic mice overexpressing Hamp and found that Hamp inhibited the iron accumulation normally observed in the Hfe-/- mice.	Iron	98-102	homeostatic iron regulator	Mus musculus	11-14
12704388-9	2003	We crossed Hfe-/- mice with transgenic mice overexpressing Hamp and found that Hamp inhibited the iron accumulation normally observed in the Hfe-/- mice.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	59-63
12704388-9	2003	We crossed Hfe-/- mice with transgenic mice overexpressing Hamp and found that Hamp inhibited the iron accumulation normally observed in the Hfe-/- mice.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	79-83
12704388-9	2003	We crossed Hfe-/- mice with transgenic mice overexpressing Hamp and found that Hamp inhibited the iron accumulation normally observed in the Hfe-/- mice.	Iron	98-102	homeostatic iron regulator	Mus musculus	141-144
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	35-39	RoBo-1	Rattus norvegicus	82-110
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	35-39	RoBo-1	Rattus norvegicus	112-117
12468424-5	2003	In both normal and Hfe knock-out mice, duodenal nonheme iron content was found to correlate with liver iron stores (P &lt;.001, r = 0.643 and 0.551, respectively), and this effect did not depend on dietary iron levels.	Iron	56-60	homeostatic iron regulator	Mus musculus	19-22
12468424-5	2003	In both normal and Hfe knock-out mice, duodenal nonheme iron content was found to correlate with liver iron stores (P &lt;.001, r = 0.643 and 0.551, respectively), and this effect did not depend on dietary iron levels.	Iron	103-107	homeostatic iron regulator	Mus musculus	19-22
12468424-5	2003	In both normal and Hfe knock-out mice, duodenal nonheme iron content was found to correlate with liver iron stores (P &lt;.001, r = 0.643 and 0.551, respectively), and this effect did not depend on dietary iron levels.	Iron	103-107	homeostatic iron regulator	Mus musculus	19-22
12468424-6	2003	However, duodenal iron content was reduced in Hfe knock-out mice for any given content of liver iron stores (P &lt;.001).	Iron	18-22	homeostatic iron regulator	Mus musculus	46-49
12468424-6	2003	However, duodenal iron content was reduced in Hfe knock-out mice for any given content of liver iron stores (P &lt;.001).	Iron	96-100	homeostatic iron regulator	Mus musculus	46-49
12480705-6	2003	Furthermore, in vitro and in vivo pull-down assays revealed that ABC7 protein is interacted with the carboxy-terminal region containing the iron-sulfur cluster of ferrochelatase.	Iron	140-144	ferrochelatase	Mus musculus	163-177
12480705-11	2003	The results indicated that ABC7 positively regulates not only the expression of extramitochondrial thioredoxin but also that of an intramitochondrial iron-sulfur-containing protein, ferrochelatase.	Iron	150-154	ferrochelatase	Mus musculus	182-196
12456502-0	2003	A single viral protein HCMV US2 affects antigen presentation and intracellular iron homeostasis by degradation of classical HLA class I and HFE molecules.	Iron	79-83	membrane glycoprotein US2	Human betaherpesvirus 5	28-31
12456502-8	2003	This HCMV US2-mediated degradation of HFE leads to increased intracellular iron pools as indicated by reduced synthesis of TfR and increased ferritin synthesis.	Iron	75-79	membrane glycoprotein US2	Human betaherpesvirus 5	10-13
12734938-1	2003	OBJECTIVE: To investigate the expression of divalent metal transporter 1 (DMT1) mRNA in male Sprague-Dawley rat heart of different ages and the expression of DMT1 regulated by dietary iron.	Iron	184-188	RoBo-1	Rattus norvegicus	158-162
12734938-3	2003	RESULTS: (1)Two isoforms of DMT1 mRNA [with and without iron-responsive element (IRE)] were both detected in rat heart, which were correlated with heart iron content.	Iron	56-60	RoBo-1	Rattus norvegicus	28-32
12734938-3	2003	RESULTS: (1)Two isoforms of DMT1 mRNA [with and without iron-responsive element (IRE)] were both detected in rat heart, which were correlated with heart iron content.	Iron	153-157	RoBo-1	Rattus norvegicus	28-32
12734938-7	2003	By using Western blot analysis, a 21% and 40% reduction in DMT1 protein non IRE form and IRE form respectively were found in iron overload rat (P&lt;0.01, compared with control).	Iron	125-129	RoBo-1	Rattus norvegicus	59-63
12734938-9	2003	CONCLUSION: The level of DMT1 mRNA expression in heart is age dependent;the two isoforms of DMT1 protein may be both regulated by iron on the posttranscriptional mechanism.	Iron	130-134	RoBo-1	Rattus norvegicus	25-29
12734938-9	2003	CONCLUSION: The level of DMT1 mRNA expression in heart is age dependent;the two isoforms of DMT1 protein may be both regulated by iron on the posttranscriptional mechanism.	Iron	130-134	RoBo-1	Rattus norvegicus	92-96
12644631-0	2003	Proteomic approach to coronary atherosclerosis shows ferritin light chain as a significant marker: evidence consistent with iron hypothesis in atherosclerosis.	Iron	124-128	ferritin light chain	Homo sapiens	53-73
12644631-6	2003	Ferritin light chain protein mediates storage of iron in cells.	Iron	49-53	ferritin light chain	Homo sapiens	0-20
12675342-6	2003	The proposed method was successfully applied to the speciation of reactive and unreactive iron in tap- and river-water samples.	Iron	90-94	nuclear RNA export factor 1	Homo sapiens	98-101
12572672-3	2003	Moreover, NO*, a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels.	Iron	77-81	aconitase 1	Mus musculus	96-100
12572672-1	2003	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	aconitase 1	Mus musculus	26-30
12572672-1	2003	Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs.	Iron	121-125	iron responsive element binding protein 2	Mus musculus	35-39
12572672-7	2003	These results suggest that NO+-mediated degradation of IRP2 plays a major role in iron metabolism during inflammation.	Iron	82-86	iron responsive element binding protein 2	Mus musculus	55-59
12572681-8	2003	In the current paper we have shown that iron induces an imbalance in the function of Cdk5/p25 system of hippocampal neurons, resulting in a marked decrease in tau phosphorylation at the typical Alzheimer"s epitopes.	Iron	40-44	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	90-93
12584213-7	2003	Reduced absorption was also accompanied by a rapid decrease in expression of the mRNAs encoding the brush border iron transport molecules Dcytb and the iron responsive element (IRE) containing the splice variant of DMT1.	Iron	152-156	RoBo-1	Rattus norvegicus	215-219
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Iron	101-105	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-54
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Iron	101-105	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
12753426-2	2003	Results from expression experiments in Xenopus oocytes indicate that DMT1 can mediate transport of a wide range of divalent metals other than iron.	Iron	142-146	solute carrier family 11 member 2 L homeolog	Xenopus laevis	69-73
12553831-5	2003	With cyanide anions, complex 1 forms the adduct [(n-Bu)(4)N][Fe(III)(gma(*))(CN)] (S(t) = 1) (4), which can be one-electron oxidized with iodine yielding the neutral species [Fe(III)(gma)(CN)] (S(t) = 1/2) (5).	Iron	61-63	myelin associated glycoprotein	Homo sapiens	69-72
12553831-5	2003	With cyanide anions, complex 1 forms the adduct [(n-Bu)(4)N][Fe(III)(gma(*))(CN)] (S(t) = 1) (4), which can be one-electron oxidized with iodine yielding the neutral species [Fe(III)(gma)(CN)] (S(t) = 1/2) (5).	Iron	61-63	myelin associated glycoprotein	Homo sapiens	183-186
12553831-11	2003	In the case of [Fe(gma)(PH(3))], [Fe(gma)(py)], and [Fe(gma)(CN)](-) an electron transfer from the iron to the gma LUMO takes place to give strong antiferromagnetic coupling between an intermediate spin Fe(III) (S(Fe) = 3/2) and (gma(*))(3)(-) (S(gma) = 1/2), yielding a total spin S(t) = 1.	Iron	99-103	myelin associated glycoprotein	Homo sapiens	19-22
12553831-11	2003	In the case of [Fe(gma)(PH(3))], [Fe(gma)(py)], and [Fe(gma)(CN)](-) an electron transfer from the iron to the gma LUMO takes place to give strong antiferromagnetic coupling between an intermediate spin Fe(III) (S(Fe) = 3/2) and (gma(*))(3)(-) (S(gma) = 1/2), yielding a total spin S(t) = 1.	Iron	99-103	myelin associated glycoprotein	Homo sapiens	37-40
12553831-11	2003	In the case of [Fe(gma)(PH(3))], [Fe(gma)(py)], and [Fe(gma)(CN)](-) an electron transfer from the iron to the gma LUMO takes place to give strong antiferromagnetic coupling between an intermediate spin Fe(III) (S(Fe) = 3/2) and (gma(*))(3)(-) (S(gma) = 1/2), yielding a total spin S(t) = 1.	Iron	99-103	myelin associated glycoprotein	Homo sapiens	37-40
12553831-11	2003	In the case of [Fe(gma)(PH(3))], [Fe(gma)(py)], and [Fe(gma)(CN)](-) an electron transfer from the iron to the gma LUMO takes place to give strong antiferromagnetic coupling between an intermediate spin Fe(III) (S(Fe) = 3/2) and (gma(*))(3)(-) (S(gma) = 1/2), yielding a total spin S(t) = 1.	Iron	99-103	myelin associated glycoprotein	Homo sapiens	37-40
12553831-11	2003	In the case of [Fe(gma)(PH(3))], [Fe(gma)(py)], and [Fe(gma)(CN)](-) an electron transfer from the iron to the gma LUMO takes place to give strong antiferromagnetic coupling between an intermediate spin Fe(III) (S(Fe) = 3/2) and (gma(*))(3)(-) (S(gma) = 1/2), yielding a total spin S(t) = 1.	Iron	99-103	myelin associated glycoprotein	Homo sapiens	37-40
12553831-11	2003	In the case of [Fe(gma)(PH(3))], [Fe(gma)(py)], and [Fe(gma)(CN)](-) an electron transfer from the iron to the gma LUMO takes place to give strong antiferromagnetic coupling between an intermediate spin Fe(III) (S(Fe) = 3/2) and (gma(*))(3)(-) (S(gma) = 1/2), yielding a total spin S(t) = 1.	Iron	99-103	myelin associated glycoprotein	Homo sapiens	37-40
12553831-13	2003	By contrast, the complexes [Fe(gma)(PH(3))(2)] and [Fe(PhBMA)] feature closed-shell ligands with a low-spin Fe(II) (S(Fe) = S(t) = 0) and an intermediate spin central Fe(II) (S(Fe) = S(t) = 1), respectively.	Iron	28-30	myelin associated glycoprotein	Homo sapiens	31-34
12393610-2	2003	Mice with the Alas2-null phenotype showed massive cytoplasmic, but not mitochondrial, iron accumulation in their primitive erythroblasts.	Iron	86-90	aminolevulinic acid synthase 2, erythroid	Mus musculus	14-19
12393610-8	2003	In contrast, Alas2-null definitive erythroblasts contained 15 times more nonheme iron than did the wild-type erythroblasts, and electron microscopy found this iron to be distributed in the cytoplasm but not in mitochondria.	Iron	81-85	aminolevulinic acid synthase 2, erythroid	Mus musculus	13-18
12393610-8	2003	In contrast, Alas2-null definitive erythroblasts contained 15 times more nonheme iron than did the wild-type erythroblasts, and electron microscopy found this iron to be distributed in the cytoplasm but not in mitochondria.	Iron	159-163	aminolevulinic acid synthase 2, erythroid	Mus musculus	13-18
12393610-9	2003	Consistent with the aberrant increase in iron, Alas2-null definitive erythroblasts were more peroxidized than wild-type erythroblasts.	Iron	41-45	aminolevulinic acid synthase 2, erythroid	Mus musculus	47-52
12393610-10	2003	These findings suggest that ALAS2 deficiency itself does not interfere with the development of definitive erythroid cells, but it results in a profound iron accumulation and a peroxidized state in erythroblasts.	Iron	152-156	aminolevulinic acid synthase 2, erythroid	Mus musculus	28-33
12540785-7	2003	The increases in nonheme iron in Hfe(-/-) mice were associated with diffuse increases in iron staining of parenchymal cells but without evidence of significant liver injury.	Iron	25-29	homeostatic iron regulator	Mus musculus	33-36
12540785-7	2003	The increases in nonheme iron in Hfe(-/-) mice were associated with diffuse increases in iron staining of parenchymal cells but without evidence of significant liver injury.	Iron	89-93	homeostatic iron regulator	Mus musculus	33-36
12570638-2	2003	When a spin-polarized electron current flows from Co into Cu(Fe) wires through the Co/Cu(Fe) interface, the resistivity of the Cu(Fe) wire is suppressed near the interface, as distinct from the ordinary logarithmic increase in the resistivity at low temperatures.	Iron	61-63	spindlin 1	Homo sapiens	7-11
12478613-0	2003	Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.	Iron	49-53	ferritin heavy polypeptide 1	Mus musculus	26-36
12478613-9	2003	The other iron management proteins transferrin, transferrin receptor, light chain ferritin, Divalent Metal Transporter 1, ceruloplasmin, were increased in the +/- mice compared to +/+ mice.	Iron	10-14	transferrin	Mus musculus	35-46
12440891-2	2002	Following co-deposition of iron atoms and 1,3,5-tricarboxylic benzoic acid (trimesic acid, TMA) on Cu(100) in ultrahigh vaccum, TMA molecules react with the metal centers, and metal-ligand interactions stabilize R and S chiral complexes which are clearly distinguished by STM.	Iron	27-31	sulfotransferase family 1A member 3	Homo sapiens	272-275
12431098-2	2002	Binding of NO to the heme iron of the NT-HBD of HRI activates its eIF2alpha kinase activity, thus inhibiting the initiation of translation in reticulocyte lysate.	Iron	26-30	eukaryotic translation initiation factor 2A	Homo sapiens	66-75
12417755-1	2002	Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by ferrochelatase inserting ferrous iron into protoporphyrin IX.	Iron	33-37	ferrochelatase	Homo sapiens	89-103
12417755-1	2002	Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by ferrochelatase inserting ferrous iron into protoporphyrin IX.	Iron	114-126	ferrochelatase	Homo sapiens	89-103
12547217-0	2002	Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?	Iron	92-96	homeostatic iron regulator	Mus musculus	25-28
12547217-3	2002	This result contrasted with mice deficient in the hemochromatosis protein, HFE, which demonstrated a significant increase in normally high hepatic iron levels, but no change in splenic iron, when fed an iron-enriched chow.	Iron	147-151	homeostatic iron regulator	Mus musculus	75-78
12547217-6	2002	These results suggest that HFE and TNFR2 are both involved in regulating iron deposition in tissues and that the regulation occurs at the level of the intestine through IEL-orchestrated production of TNF following the binding to TNFR2.	Iron	73-77	homeostatic iron regulator	Mus musculus	27-30
12547217-7	2002	These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron.	Iron	80-84	homeostatic iron regulator	Mus musculus	24-27
12547217-7	2002	These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron.	Iron	140-144	homeostatic iron regulator	Mus musculus	24-27
12547225-0	2002	Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism.	Iron	67-71	cytochrome b reductase 1	Homo sapiens	34-55
12547225-0	2002	Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism.	Iron	67-71	cytochrome b reductase 1	Homo sapiens	57-62
12547225-1	2002	Dcytb has been identified as the mammalian transplasma ferric reductase that catalyzes the reduction of ferric to ferrous iron in the process of iron absorption.	Iron	122-126	cytochrome b reductase 1	Homo sapiens	0-5
12547225-1	2002	Dcytb has been identified as the mammalian transplasma ferric reductase that catalyzes the reduction of ferric to ferrous iron in the process of iron absorption.	Iron	145-149	cytochrome b reductase 1	Homo sapiens	0-5
12547225-5	2002	Dcytb expression and function were modulated by iron.	Iron	48-52	cytochrome b reductase 1	Homo sapiens	0-5
12553165-12	2002	It was estimated that the iron-binding capacity of transferrin in CSF was exceeded, suggesting that iron is transported into the brain in a quantity that exceeds that of transferrin.	Iron	26-30	colony stimulating factor 2	Rattus norvegicus	66-69
12553165-12	2002	It was estimated that the iron-binding capacity of transferrin in CSF was exceeded, suggesting that iron is transported into the brain in a quantity that exceeds that of transferrin.	Iron	100-104	colony stimulating factor 2	Rattus norvegicus	66-69
12379471-6	2002	HO-1 catalyzes the rate-limiting step in heme degradation to form carbon monoxide (CO), biliverdin and free iron.	Iron	108-112	heme oxygenase 1	Cricetulus griseus	0-4
12176980-3	2002	This response is dependent on the Aft1 protein, a transcriptional factor known to regulate a set of genes involved in iron uptake and homeostasis (iron regulon).	Iron	118-122	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	34-38
12176980-3	2002	This response is dependent on the Aft1 protein, a transcriptional factor known to regulate a set of genes involved in iron uptake and homeostasis (iron regulon).	Iron	147-151	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	34-38
12176980-4	2002	Like iron starvation, cobalt stress induces accumulation of the Aft1 protein in the nucleus to activate transcription of its target genes.	Iron	5-9	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	64-68
12176980-6	2002	Cobalt resistance correlates with an increase in intracellular iron in AFT1-1(up) cells, and sensitivity of aft1 cells is associated with a lack of iron accumulation.	Iron	63-67	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	71-75
12176980-6	2002	Cobalt resistance correlates with an increase in intracellular iron in AFT1-1(up) cells, and sensitivity of aft1 cells is associated with a lack of iron accumulation.	Iron	148-152	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	108-112
12176980-7	2002	Furthermore, elevated iron levels in the growth medium suppress the cobalt sensitivity of the aft1 mutant cells, even though they increase cellular cobalt.	Iron	22-26	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	94-98
12176980-8	2002	Results presented indicate that yeast cells acquire cobalt tolerance by activating the Aft1p-dependent iron regulon and thereby increasing intracellular iron levels.	Iron	103-107	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	87-92
12176980-8	2002	Results presented indicate that yeast cells acquire cobalt tolerance by activating the Aft1p-dependent iron regulon and thereby increasing intracellular iron levels.	Iron	153-157	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	87-92
12297827-2	2002	Acute iron administration or mutations of the hemochromatosis gene (Hfe) have been used to generate hepatic siderosis, a nearly uniform finding in PCT.	Iron	6-10	homeostatic iron regulator	Mus musculus	68-71
12297827-6	2002	Homozygosity for an Hfe-null mutation significantly elevated hepatic iron but not to the extent seen with parenteral iron-dextran administration.	Iron	69-73	homeostatic iron regulator	Mus musculus	20-23
12392996-1	2002	Heme oxygenase-1 (HO-1) is a heat shock protein catalysing the degradation of heme to yield biliverdin, carbon monoxide and iron.	Iron	124-128	heme oxygenase 1	Rattus norvegicus	0-16
12392996-1	2002	Heme oxygenase-1 (HO-1) is a heat shock protein catalysing the degradation of heme to yield biliverdin, carbon monoxide and iron.	Iron	124-128	heme oxygenase 1	Rattus norvegicus	18-22
12382200-18	2002	Mice with a targeted disruption of a gene for iron regulatory protein 2 (IRP2), a translational repressor of ferritin, misregulate iron metabolism in the intestinal mucosa and the central nervous system.	Iron	46-50	iron responsive element binding protein 2	Mus musculus	73-77
12065085-10	2002	Induction in ornithine decarboxylase (ODC) activity, [(3)H]thymidine incorporation in cutaneous DNA and cutaneous lipid peroxidation were also higher in the iron-overloaded mice.	Iron	157-161	ornithine decarboxylase, structural 1	Mus musculus	13-36
12065085-10	2002	Induction in ornithine decarboxylase (ODC) activity, [(3)H]thymidine incorporation in cutaneous DNA and cutaneous lipid peroxidation were also higher in the iron-overloaded mice.	Iron	157-161	ornithine decarboxylase, structural 1	Mus musculus	38-41
12209009-1	2002	Intracellular iron homeostasis is regulated posttranscriptionally by iron regulatory proteins 1 and 2 (IRP1 and IRP2).	Iron	14-18	aconitase 1	Mus musculus	103-107
12209009-1	2002	Intracellular iron homeostasis is regulated posttranscriptionally by iron regulatory proteins 1 and 2 (IRP1 and IRP2).	Iron	14-18	iron responsive element binding protein 2	Mus musculus	112-116
12209009-2	2002	In the absence of iron in the labile pool, IRPs bind to specific nucleotide sequences called iron responsive elements (IREs), which are located in the 5" untranslated region of ferritin mRNA and the 3" untranslated region of transferrin receptor mRNA.	Iron	93-97	transferrin	Mus musculus	225-236
12209009-9	2002	These observations indicate that NO+-mediated modulation of IRP2 plays an important role in controlling ferritin synthesis and iron metabolism in murine macrophages.	Iron	127-131	iron responsive element binding protein 2	Mus musculus	60-64
12095998-7	2002	First, we found that FET4 expression is induced in iron-limited cells by the Aft1 iron-responsive transcriptional activator.	Iron	51-55	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	77-81
12095998-7	2002	First, we found that FET4 expression is induced in iron-limited cells by the Aft1 iron-responsive transcriptional activator.	Iron	82-86	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	77-81
12226668-3	2002	Here we show that AlkB from Escherichia coli is indeed a 2-oxoglutarate-dependent and iron-dependent DNA repair enzyme that releases replication blocks in alkylated DNA by a mechanism involving oxidative demethylation of 1-methyladenine residues.	Iron	86-90	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	18-22
12429222-9	2002	The observation that DMT-1 is present on astrocytic end feet in contact with blood vessels suggests that these cells may be involved in uptake of iron from endothelial cells.	Iron	146-150	RoBo-1	Rattus norvegicus	21-26
12165564-9	2002	Furthermore, Yfh1p-depleted Gal-YFH1 cells show decreased maturation of cytosolic Fe/S proteins and accumulation of mitochondrial iron.	Iron	130-134	ferroxidase	Saccharomyces cerevisiae S288C	13-18
12165564-9	2002	Furthermore, Yfh1p-depleted Gal-YFH1 cells show decreased maturation of cytosolic Fe/S proteins and accumulation of mitochondrial iron.	Iron	130-134	ferroxidase	Saccharomyces cerevisiae S288C	32-36
12134060-6	2002	The homozygous Tfr2(Y245X) mutant mice showed profound abnormalities in parameters of iron homeostasis.	Iron	86-90	transferrin receptor 2	Mus musculus	15-19
12134060-7	2002	Even on a standard diet, hepatic iron concentration was several-fold higher in the homozygous Tfr2(Y245X) mutant mice than in wild-type littermates by 4 weeks of age.	Iron	33-37	transferrin receptor 2	Mus musculus	94-98
12134060-9	2002	The mean splenic iron concentration in the homozygous Tfr2(Y245X) mutant mice was significantly less than that observed in the wild-type mice.	Iron	17-21	transferrin receptor 2	Mus musculus	54-58
12134060-13	2002	This study confirms the important role for TFR2 in iron homeostasis and provides a tool for investigating the excess iron absorption and abnormal iron distribution in iron-overload disorders.	Iron	51-55	transferrin receptor 2	Mus musculus	43-47
12190960-10	2002	CONCLUSION: C57BL/6 x 129/O1a HFE(o/o) mice mimic HH iron distribution and the regulation of intestinal iron absorption after long-term feeding.	Iron	53-57	homeostatic iron regulator	Mus musculus	30-33
12190960-10	2002	CONCLUSION: C57BL/6 x 129/O1a HFE(o/o) mice mimic HH iron distribution and the regulation of intestinal iron absorption after long-term feeding.	Iron	104-108	homeostatic iron regulator	Mus musculus	30-33
12420740-6	2002	Since the use of DEN is known to lead to the production of lipid peroxidation products which facilitate this reaction and haptoglobin is an acute phase reactant, acting as a radical scavenger against hemoglobin or iron stimulated lipid peroxidation, a relationship between the glycosylation of haptoglobin and the suppression of hepatoma development can not be ruled out.	Iron	214-218	haptoglobin	Mus musculus	122-133
12420740-6	2002	Since the use of DEN is known to lead to the production of lipid peroxidation products which facilitate this reaction and haptoglobin is an acute phase reactant, acting as a radical scavenger against hemoglobin or iron stimulated lipid peroxidation, a relationship between the glycosylation of haptoglobin and the suppression of hepatoma development can not be ruled out.	Iron	214-218	haptoglobin	Mus musculus	294-305
12224370-7	2002	Newer methods of measuring iron status, such as reticulocyte hemoglobin content (CHr), may be less variable and more sensitive and specific than the current iron parameters.	Iron	27-31	chromate resistance; sulfate transport	Homo sapiens	81-84
12044177-0	2002	Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.	Iron	122-124	aconitase 1	Mus musculus	44-69
12044177-0	2002	Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.	Iron	122-124	aconitase 1	Mus musculus	138-159
12044177-1	2002	Posttranscriptional regulation of iron homeostasis involves, among other factors, a reversible conversion of the Fe-S enzyme cytoplasmic aconitase to a mRNA-binding iron regulatory protein (IRP-1) that lacks an Fe-S cluster.	Iron	34-38	aconitase 1	Mus musculus	125-146
12044177-1	2002	Posttranscriptional regulation of iron homeostasis involves, among other factors, a reversible conversion of the Fe-S enzyme cytoplasmic aconitase to a mRNA-binding iron regulatory protein (IRP-1) that lacks an Fe-S cluster.	Iron	34-38	aconitase 1	Mus musculus	190-195
12044177-1	2002	Posttranscriptional regulation of iron homeostasis involves, among other factors, a reversible conversion of the Fe-S enzyme cytoplasmic aconitase to a mRNA-binding iron regulatory protein (IRP-1) that lacks an Fe-S cluster.	Iron	113-117	aconitase 1	Mus musculus	125-146
12044177-1	2002	Posttranscriptional regulation of iron homeostasis involves, among other factors, a reversible conversion of the Fe-S enzyme cytoplasmic aconitase to a mRNA-binding iron regulatory protein (IRP-1) that lacks an Fe-S cluster.	Iron	113-117	aconitase 1	Mus musculus	190-195
12044177-6	2002	Three lines of evidence confirmed that ONOO(-) activated IRP-1 by removing iron from the Fe-S cluster of cytoplasmic aconitase.	Iron	75-79	aconitase 1	Mus musculus	57-62
12044177-6	2002	Three lines of evidence confirmed that ONOO(-) activated IRP-1 by removing iron from the Fe-S cluster of cytoplasmic aconitase.	Iron	75-79	aconitase 1	Mus musculus	105-126
12044177-6	2002	Three lines of evidence confirmed that ONOO(-) activated IRP-1 by removing iron from the Fe-S cluster of cytoplasmic aconitase.	Iron	89-93	aconitase 1	Mus musculus	57-62
12044177-6	2002	Three lines of evidence confirmed that ONOO(-) activated IRP-1 by removing iron from the Fe-S cluster of cytoplasmic aconitase.	Iron	89-93	aconitase 1	Mus musculus	105-126
12044177-7	2002	First, IRP-1 activation was accompanied by iron release and loss of aconitase activity.	Iron	43-47	aconitase 1	Mus musculus	7-12
12044177-9	2002	Third, iron release and IRP-1 activation were observed in lysates from control or iron-loaded macrophages, containing increasing levels of Fe-S clusters, but not in lysates from iron-starved macrophages, in which aconitase had already undergone cluster disassembly and switched to IRP-1.	Iron	82-86	aconitase 1	Mus musculus	24-29
12044177-9	2002	Third, iron release and IRP-1 activation were observed in lysates from control or iron-loaded macrophages, containing increasing levels of Fe-S clusters, but not in lysates from iron-starved macrophages, in which aconitase had already undergone cluster disassembly and switched to IRP-1.	Iron	139-143	aconitase 1	Mus musculus	24-29
12044177-9	2002	Third, iron release and IRP-1 activation were observed in lysates from control or iron-loaded macrophages, containing increasing levels of Fe-S clusters, but not in lysates from iron-starved macrophages, in which aconitase had already undergone cluster disassembly and switched to IRP-1.	Iron	82-86	aconitase 1	Mus musculus	24-29
12044177-12	2002	These results indicate that *NO and ONOO(-) may activate IRP-1 by attacking the Fe-S cluster of cytoplasmic aconitase, while also inactivating the cluster-deficient IRP-2.	Iron	80-84	aconitase 1	Mus musculus	57-62
12044177-12	2002	These results indicate that *NO and ONOO(-) may activate IRP-1 by attacking the Fe-S cluster of cytoplasmic aconitase, while also inactivating the cluster-deficient IRP-2.	Iron	80-84	aconitase 1	Mus musculus	96-117
12029631-3	2002	Comparative analysis of the respective spot patterns in 2DE showed that tissue ferritin light chain (T-FLC), an iron-storage protein, was either severely suppressed or reduced to undetectable levels in HCC, which was further supported by Western blot and immunohistochemical analysis.	Iron	112-116	ferritin light chain	Homo sapiens	79-99
12164080-6	2002	Newer methods, such as reticulocyte hemoglobin content (CHr), provide a more accurate estimate of available iron and should be used more often by health care providers.	Iron	108-112	chromate resistance; sulfate transport	Homo sapiens	56-59
12545754-0	2002	[Effect of iron on the expression of uncoupling protein 2, 3 gene of obese rat].	Iron	11-15	uncoupling protein 2	Rattus norvegicus	37-57
12545754-1	2002	In order to study the effect of iron on the expression of UCP2 in white fat and UCP3 in muscle in obese rats, a reverse transcription polymerase chain reaction (RT-PCR) technique is used to measure the expression of UCP2 and UCP3 mRNA.	Iron	32-36	uncoupling protein 2	Rattus norvegicus	58-62
12545754-1	2002	In order to study the effect of iron on the expression of UCP2 in white fat and UCP3 in muscle in obese rats, a reverse transcription polymerase chain reaction (RT-PCR) technique is used to measure the expression of UCP2 and UCP3 mRNA.	Iron	32-36	uncoupling protein 2	Rattus norvegicus	216-220
11877447-0	2002	Subcellular localization of Aft1 transcription factor responds to iron status in Saccharomyces cerevisiae.	Iron	66-70	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	28-32
12052492-7	2002	Under similar conditions, two kinetic processes for iron release from PSF and bacterial ferritin of Azoaobacter vinelandii (AvBF) were studied and both fit a zero-order law.	Iron	52-56	BFT	Sus scrofa	124-128
12019217-2	2002	A deficiency of this protein in humans causes Friedreich"s ataxia, while its complete absence in yeast (Delta yfh1 mutant) results in loss of mitochondrial DNA, apparently due to radicals generated by excess iron.	Iron	208-212	ferroxidase	Saccharomyces cerevisiae S288C	110-114
12367579-0	2002	Iron overload in mice expressing HFE exclusively in the intestinal villi provides evidence that HFE regulates a functional cross-talk between crypt and villi enterocytes.	Iron	0-4	homeostatic iron regulator	Mus musculus	33-36
12367579-0	2002	Iron overload in mice expressing HFE exclusively in the intestinal villi provides evidence that HFE regulates a functional cross-talk between crypt and villi enterocytes.	Iron	0-4	homeostatic iron regulator	Mus musculus	96-99
12367579-1	2002	Hereditary hemochromatosis (HH), a common autosomal recessive disorder due to a mutation in HFE, which encodes an atypical MHC class I glycoprotein, is characterized by excessive absorption of dietary iron.	Iron	201-205	homeostatic iron regulator	Mus musculus	92-95
12367579-2	2002	Little is known however of the apparently complex pathophysiology of HFE involvement in the process of iron influx.	Iron	103-107	homeostatic iron regulator	Mus musculus	69-72
11891134-5	2002	Both deduced amino acid sequences show substantial similarity to human IRP1 and Drosophila IRP1A and IRP1B, and all of the residues thought to be involved in aconitase activity and iron-sulfur cluster formation are conserved.	Iron	181-185	Iron regulatory protein 1A	Drosophila melanogaster	91-96
11953395-2	2002	Transferrin has been implicated as a critical iron store for N. gonorrhoeae in the human male urethra.	Iron	46-50	transferrin	Mus musculus	0-11
11953395-9	2002	Finally, transferrin-binding lipoprotein (TbpB) was detected on gonococci in vaginal smears, suggesting that although gonococci replicate within the genital tracts of mice, they may be sufficiently iron-stressed to express iron-repressible proteins.	Iron	198-202	transferrin	Mus musculus	9-20
11953395-9	2002	Finally, transferrin-binding lipoprotein (TbpB) was detected on gonococci in vaginal smears, suggesting that although gonococci replicate within the genital tracts of mice, they may be sufficiently iron-stressed to express iron-repressible proteins.	Iron	223-227	transferrin	Mus musculus	9-20
12051835-12	2002	Sequences downstream of -490 harbor a consensus binding site for the iron regulatory factor Aft1p that is essential for iron regulation in wild-type strains.	Iron	69-73	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	92-97
12051835-13	2002	In addition, a secondary mode of iron regulation becomes evident in strains lacking AFT1.	Iron	33-37	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	84-88
12184662-4	2002	There is preliminary evidence to suggest that non-transferrin-bound iron uptake in the myocardium may occur through voltage-dependent L-type calcium channels, and that calcium channel blockers (CCBs) may possess antioxidant properties.	Iron	68-72	transferrin	Mus musculus	50-61
11960353-7	2002	The simultaneous addition of exogenous iron reversed NO-mediated inhibition of cell growth, caspase activation and apoptosis in all BCR-ABL(+) cells tested.	Iron	39-43	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	132-139
11860021-2	2002	They have severe anemia, suggesting that transferrin is essential for iron uptake by erythroid cells in the bone barrow.	Iron	70-74	transferrin	Mus musculus	41-52
11860021-8	2002	These results suggest that transferrin-dependent iron uptake by erythroid cells in the bone marrow is essential for the development of erythrocytes.	Iron	49-53	transferrin	Mus musculus	27-38
11886438-1	2002	BACKGROUND: The iron chelators deferoxamine (DF) and deferiprone (CP20) have been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in human peripheral blood lymphocytes (PBL).	Iron	16-20	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	66-70
12168723-2	2002	Iron induced generation of reactive oxygen species (ROS) in vitro reduces both the Na+K+-ATPase activity and Na+-Ca2+ exchanger of synaptosomal membranes, concomitantly with alteration of physical state of membranes.	Iron	0-4	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	109-116
11847243-5	2002	Cadmium exposure also influenced the amounts of nutrients found, whereby after exposure to high Cd concentrations (0.5, 1.0 microM) during growth, cad1-3 roots contained less Fe, K, Mg, P, and S compared to roots of the wild type.	Iron	175-177	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	147-151
11841242-2	2002	Electron paramagnetic resonance spectroscopy shows that hydroxyurea reacts with oxy-, deoxy-, and methemoglobin to produce 2-6% of iron nitrosyl hemoglobin.	Iron	131-135	hemoglobin subunit gamma 2	Homo sapiens	98-111
11829747-8	2002	Iron regulation of SMF3 was dramatically reduced, but not completely eliminated, in strains lacking both the AFT1 and AFT2 iron regulatory factors.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	109-113
11852098-2	2002	Frataxin is a mitochondrial protein involved in iron homeostasis.	Iron	48-52	frataxin	Mus musculus	0-8
11869357-2	2002	In a number of situations ranging from chronic inflammatory conditions and infectious diseases to ageing, immunodeficiency, iron overload and heavy alcohol intake, major phenotypic changes, usually associated with an increase in CD8+ T cells lacking CD28 expression, take place.	Iron	124-128	CD8a molecule	Homo sapiens	229-232
11882623-1	2002	Heme oxygenase enzymes (HO-1 and HO-2) catalyze the conversion of heme to biliverdin, free iron, and carbon monoxide (CO).	Iron	91-95	heme oxygenase 1	Rattus norvegicus	24-28
11707449-0	2002	Movement of the iron-sulfur subunit beyond the ef loop of cytochrome b is required for multiple turnovers of the bc1 complex but not for single turnover Qo site catalysis.	Iron	16-20	mitochondrially encoded cytochrome b	Homo sapiens	58-70
11707449-5	2002	These findings indicate that the movement of the iron-sulfur subunit is composed of two discrete parts: a "micro-movement" at the cytochrome b interface, during which the [2Fe-2S] cluster interacts with ubihydroquinone oxidation site occupants and catalyzes ubihydroquinone oxidation, and a "macro-movement," during which the cluster domain swings away from cytochrome b interface, crosses the ef loop, and reaches a position close to cytochrome c(1) heme, to which it ultimately transfers an electron.	Iron	49-53	mitochondrially encoded cytochrome b	Homo sapiens	130-142
11707449-5	2002	These findings indicate that the movement of the iron-sulfur subunit is composed of two discrete parts: a "micro-movement" at the cytochrome b interface, during which the [2Fe-2S] cluster interacts with ubihydroquinone oxidation site occupants and catalyzes ubihydroquinone oxidation, and a "macro-movement," during which the cluster domain swings away from cytochrome b interface, crosses the ef loop, and reaches a position close to cytochrome c(1) heme, to which it ultimately transfers an electron.	Iron	49-53	mitochondrially encoded cytochrome b	Homo sapiens	358-370
11842150-1	2002	Chlamydomonas reinhardtii activates Cpx1, Cyc6, and Crd1, encoding, respectively, coproporphyrinogen oxidase, cytochrome c(6), and a novel di-iron enzyme when transferred to oxygen-deficient growth conditions.	Iron	142-146	uncharacterized protein	Chlamydomonas reinhardtii	36-40
11826284-3	2002	Despite the discovery of the mutation underlying most cases of HH, considerable uncertainty exists in the mechanism by which the normal gene product, HFE, regulates iron homeostasis.	Iron	165-169	homeostatic iron regulator	Mus musculus	150-153
11826284-5	2002	However, studies on HFE expressed in cultured cells have not yet clarified the mechanism by which HFE mutations lead to increased dietary iron absorption.	Iron	138-142	homeostatic iron regulator	Mus musculus	98-101
11826284-6	2002	Recent discoveries suggest other genes, including a second transferrin receptor and the circulating peptide hepcidin, participate in a shared pathway with HFE in regulation of iron absorption.	Iron	176-180	hepcidin antimicrobial peptide	Mus musculus	108-116
11826284-6	2002	Recent discoveries suggest other genes, including a second transferrin receptor and the circulating peptide hepcidin, participate in a shared pathway with HFE in regulation of iron absorption.	Iron	176-180	homeostatic iron regulator	Mus musculus	155-158
12401962-1	2002	Transferrin (Tf), the plasma protein involved in iron transport, seems to play complex physiological roles related to cell function, differentiation and proliferation.	Iron	49-53	transferrin	Mus musculus	0-11
12401962-1	2002	Transferrin (Tf), the plasma protein involved in iron transport, seems to play complex physiological roles related to cell function, differentiation and proliferation.	Iron	49-53	transferrin	Mus musculus	13-15
11602611-1	2001	The structural and physiochemical properties of 3-hydroxypyridin-4-one chelators (HPOs) which influence inhibition of the iron-containing metalloenzymes ribonucleotide reductase (RR) and 5-lipoxygenase (5-LO) have been investigated.	Iron	122-126	linoleate 9S-lipoxygenase-4	Glycine max	189-201
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	41-45	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	155-159
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	41-45	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	201-205
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	126-130	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	155-159
11673473-2	2001	FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed.	Iron	126-130	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	201-205
11673473-3	2001	Northern blot analysis confirmed that FIT1, FIT2, and FIT3 mRNA transcript levels were increased 60-230-fold in response to iron deprivation in an Aft1p-dependent manner.	Iron	124-128	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	147-152
11673473-6	2001	FIT-deletion strains exhibited increased expression of Aft1p target genes as measured by a FET3-lacZ reporter gene or by Arn1p Western blotting, indicating that cells respond to the absence of FIT genes by up-regulating systems of iron uptake.	Iron	231-235	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	55-60
11673473-7	2001	Aft1p activation in FIT-deleted strains occurred when either ferrichrome or ferric salts were used as sources of iron during growth, suggesting that the FIT genes enhance uptake of iron from both sources.	Iron	113-117	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
11673473-7	2001	Aft1p activation in FIT-deleted strains occurred when either ferrichrome or ferric salts were used as sources of iron during growth, suggesting that the FIT genes enhance uptake of iron from both sources.	Iron	181-185	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
11751190-2	2001	Mycobacterium tuberculosis is unusual in that it secretes large quantities of iron-cofactored SOD.	Iron	78-82	superoxide dismutase	Mycobacterium tuberculosis H37Rv	94-97
11746453-3	2001	The Divalent Metal Transporter 1 (DMT1), is responsible for iron uptake from the gut and transport from endosomes.	Iron	60-64	RoBo-1	Rattus norvegicus	4-32
11746453-3	2001	The Divalent Metal Transporter 1 (DMT1), is responsible for iron uptake from the gut and transport from endosomes.	Iron	60-64	RoBo-1	Rattus norvegicus	34-38
11746453-6	2001	Belgrade rats have a defect in DMT1 that is associated with lower levels of iron in the brain.	Iron	76-80	RoBo-1	Rattus norvegicus	31-35
11746453-8	2001	The staining in the ependymal cells and endothelial cells suggests that DMT1 has an important role in iron transport into the brain.	Iron	102-106	RoBo-1	Rattus norvegicus	72-76
11746453-15	2001	These results indicate that DMT1 and MTP1 are involved in brain iron transport and this involvement is regionally and cellularly specific.	Iron	64-68	RoBo-1	Rattus norvegicus	28-32
11562361-5	2001	The enzyme contains one molecule of FAD, one atom of molybdenum, and four atoms of iron per subunit and shows spectroscopic features similar to those of the prototypic molybdo-flavoprotein xanthine oxidoreductase.	Iron	83-87	xanthine dehydrogenase	Mus musculus	189-212
11734220-0	2001	YFH1-mediated iron homeostasis is independent of mitochondrial respiration.	Iron	14-18	ferroxidase	Saccharomyces cerevisiae S288C	0-4
11734220-4	2001	Deletion of YFH1 in respiratory incompetent yeast results in mitochondrial iron accumulation, while the reintroduction of Yfh1p results in mitochondrial iron export.	Iron	75-79	ferroxidase	Saccharomyces cerevisiae S288C	12-16
11734220-4	2001	Deletion of YFH1 in respiratory incompetent yeast results in mitochondrial iron accumulation, while the reintroduction of Yfh1p results in mitochondrial iron export.	Iron	153-157	ferroxidase	Saccharomyces cerevisiae S288C	122-127
11734220-6	2001	We conclude that the effect of Yfh1p on mitochondrial iron metabolism is independent of respiratory activity.	Iron	54-58	ferroxidase	Saccharomyces cerevisiae S288C	31-36
11562378-2	2001	Siderophore-iron uptake can occur through the reduction of the complex and the subsequent uptake of iron by the high affinity iron transporter Fet3p/Ftr1p.	Iron	12-16	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	149-154
11562378-2	2001	Siderophore-iron uptake can occur through the reduction of the complex and the subsequent uptake of iron by the high affinity iron transporter Fet3p/Ftr1p.	Iron	100-104	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	149-154
11727821-8	2001	Genes fyuA (ferric yersiniabactin uptake) (66.0%) and irp2 (iron-repressible protein) (68.0%), necessary for Yersinia to acquire iron in the mouse infection model, were regularly detected in combination.	Iron	60-64	iron responsive element binding protein 2	Mus musculus	54-58
11727821-8	2001	Genes fyuA (ferric yersiniabactin uptake) (66.0%) and irp2 (iron-repressible protein) (68.0%), necessary for Yersinia to acquire iron in the mouse infection model, were regularly detected in combination.	Iron	129-133	iron responsive element binding protein 2	Mus musculus	54-58
11581431-0	2001	Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis.	Iron	159-163	usherin	Homo sapiens	30-33
17582936-3	2001	The mechanisms by which a dysfunctional HFE molecule determines increased absorption of iron in HH are on the way to be fully clarified, due to the availability of a knockout mouse model.	Iron	88-92	homeostatic iron regulator	Mus musculus	40-43
11694004-8	2001	The iron content of the incisor enamel was reduced, explaining the loss of yellow pigmentation in CFTR(-) incisors.	Iron	4-8	cystic fibrosis transmembrane conductance regulator	Mus musculus	98-102
11675273-11	2001	Blood lead levels were higher for iron-deficient children for each tertile of exposure as estimated by Factors 1 and 2 for non-Asian children.	Iron	34-38	transcription termination factor 2	Homo sapiens	103-118
11689493-7	2001	JAC1, an ortholog of hscB, and SSQ1, a paralog of hscA, have been shown to be required for iron-sulfur cluster assembly in mitochondria of Saccharomyces cerevisiae.	Iron	91-95	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	0-4
11448968-0	2001	Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast.	Iron	15-19	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	75-80
11448968-0	2001	Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast.	Iron	96-100	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	75-80
11448968-1	2001	The yeast, Saccharomyces cerevisiae, contains a transcription activator, Aft1p, that regulates the transcription of the high affinity iron transport system genes.	Iron	134-138	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	73-78
11448968-5	2001	The double aft1aft2 mutant was unable to grow in iron-deprived conditions.	Iron	49-53	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	11-19
11555630-2	2001	Frataxin function is believed to be related to mitochondrial iron metabolism and free radical production.	Iron	61-65	frataxin	Mus musculus	0-8
11502175-0	2001	Human ferrochelatase: characterization of substrate-iron binding and proton-abstracting residues.	Iron	52-56	ferrochelatase	Homo sapiens	6-20
11502175-1	2001	The terminal step in heme biosynthesis, the insertion of ferrous iron into protoporphyrin IX to form protoheme, is catalyzed by the enzyme ferrochelatase (EC 4.99.1.1).	Iron	57-69	ferrochelatase	Homo sapiens	139-153
11502175-1	2001	The terminal step in heme biosynthesis, the insertion of ferrous iron into protoporphyrin IX to form protoheme, is catalyzed by the enzyme ferrochelatase (EC 4.99.1.1).	Iron	57-69	ferrochelatase	Homo sapiens	155-166
11390404-0	2001	CCC1 is a transporter that mediates vacuolar iron storage in yeast.	Iron	45-49	Ccc1p	Saccharomyces cerevisiae S288C	0-4
11390404-4	2001	Using several different criteria we demonstrated that CCC1 encodes a transporter that effects the accumulation of iron and Mn(2+) in vacuoles.	Iron	114-118	Ccc1p	Saccharomyces cerevisiae S288C	54-58
11390404-5	2001	Overexpression of CCC1, which is localized to the vacuole, lowers cytosolic iron and increases vacuolar iron content.	Iron	76-80	Ccc1p	Saccharomyces cerevisiae S288C	18-22
11390404-5	2001	Overexpression of CCC1, which is localized to the vacuole, lowers cytosolic iron and increases vacuolar iron content.	Iron	104-108	Ccc1p	Saccharomyces cerevisiae S288C	18-22
11390404-6	2001	Conversely, deletion of CCC1 results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth.	Iron	59-63	Ccc1p	Saccharomyces cerevisiae S288C	24-28
11390404-6	2001	Conversely, deletion of CCC1 results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth.	Iron	86-90	Ccc1p	Saccharomyces cerevisiae S288C	24-28
11390404-6	2001	Conversely, deletion of CCC1 results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth.	Iron	86-90	Ccc1p	Saccharomyces cerevisiae S288C	24-28
11390404-7	2001	Furthermore Delta ccc1 cells show increased sensitivity to external iron.	Iron	68-72	Ccc1p	Saccharomyces cerevisiae S288C	18-22
11390404-9	2001	These results indicate that yeast can store iron in the vacuole and that CCC1 is involved in the transfer of iron from the cytosol to the vacuole.	Iron	44-48	Ccc1p	Saccharomyces cerevisiae S288C	73-77
11390404-9	2001	These results indicate that yeast can store iron in the vacuole and that CCC1 is involved in the transfer of iron from the cytosol to the vacuole.	Iron	109-113	Ccc1p	Saccharomyces cerevisiae S288C	73-77
11468145-9	2001	This probably results from subtle changes in the intracellular labile iron pool, which would stimulate L ferritin but not H ferritin synthesis.	Iron	70-74	ferritin heavy polypeptide 1	Mus musculus	122-132
11461483-0	2001	Room-temperature spin injection from Fe into GaAs.	Iron	37-39	spindlin 1	Homo sapiens	17-21
11461483-1	2001	Injection of spin polarized electrons from a metal into a semiconductor is demonstrated for a GaAs/(In,Ga)As light emitting diode covered with Fe.	Iron	143-145	spindlin 1	Homo sapiens	13-17
11444108-10	2001	In vitro exposure to iron significantly enhanced lipid peroxidation in hepatic homogenates from untreated, melatonin-treated, or E2-injected hamsters; in the hepatic homogenates of hamsters given both E2 and melatonin, ferrous sulfate failed to augment lipid peroxidation.	Iron	21-25	cystatin 12, pseudogene	Homo sapiens	201-217
11399791-8	2001	The results of this study suggest that PCB-induced iron accumulation in hepatocytes is an early event that may be related to tumor formation, especially in female rats.	Iron	51-55	pyruvate carboxylase	Rattus norvegicus	39-42
11399791-10	2001	Consequently, iron accumulations producing oxidative damage, and enhanced cell proliferation resulting in tumor promotion may be components in the mode of action for PCB-induced hepatocarcinogenesis in rodents.	Iron	14-18	pyruvate carboxylase	Rattus norvegicus	166-169
11412104-3	2001	This study utilizes a combination of kinetic and structural probes to relate the lipoxygenase mechanism of action with structural modifications of the iron"s second coordination sphere.	Iron	151-155	linoleate 9S-lipoxygenase-4	Glycine max	81-93
11439223-2	2001	Functional expression studies in Xenopus oocytes have shown that DMT1 not only mediates transport of iron but also other divalent metal ions, including the toxic metal cadmium.	Iron	101-105	solute carrier family 11 member 2 L homeolog	Xenopus laevis	65-69
11264285-2	2001	Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin.	Iron	9-13	aconitase 1	Mus musculus	107-111
11264285-2	2001	Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin.	Iron	9-13	iron responsive element binding protein 2	Mus musculus	116-120
11264285-3	2001	Under conditions of iron starvation, both IRP1 and IRP2 bind with high affinity to cognate IREs, thus stabilizing TfR and inhibiting translation of ferritin mRNAs.	Iron	20-24	aconitase 1	Mus musculus	42-46
11264285-3	2001	Under conditions of iron starvation, both IRP1 and IRP2 bind with high affinity to cognate IREs, thus stabilizing TfR and inhibiting translation of ferritin mRNAs.	Iron	20-24	iron responsive element binding protein 2	Mus musculus	51-55
11264285-10	2001	Our data suggest that H(2)O(2) regulates cellular iron acquisition and intracellular iron distribution by both IRP1-dependent and -independent mechanisms.	Iron	85-89	aconitase 1	Mus musculus	111-115
11389189-5	2001	HO-1 inhibitors, mitochondrial permeability transition pore (MTP) blockers and antioxidants significantly attenuated cytokine-related mitochondrial iron sequestration in these cells.	Iron	148-152	heme oxygenase 1	Rattus norvegicus	0-4
11389189-8	2001	HO-1 is over-expressed in MS spinal cord astroglia and may promote mitochondrial iron deposition in MS plaques.	Iron	81-85	heme oxygenase 1	Rattus norvegicus	0-4
16120268-9	2001	As in atm1 cells, a yfh1 deletion results in both mitochondrial iron accumulation and cytosolic iron starvation.	Iron	64-68	ferroxidase	Saccharomyces cerevisiae S288C	20-24
16120268-9	2001	As in atm1 cells, a yfh1 deletion results in both mitochondrial iron accumulation and cytosolic iron starvation.	Iron	96-100	ferroxidase	Saccharomyces cerevisiae S288C	20-24
11302771-6	2001	In a rat model of radiation-induced nephropathy, we investigated changes in expression of heme oxygenase 1 (Hmox1, also known as HO-1), an enzyme that catalyzes conversion of heme into biliverdin, carbon monoxide and iron.	Iron	217-221	heme oxygenase 1	Rattus norvegicus	90-106
11302771-6	2001	In a rat model of radiation-induced nephropathy, we investigated changes in expression of heme oxygenase 1 (Hmox1, also known as HO-1), an enzyme that catalyzes conversion of heme into biliverdin, carbon monoxide and iron.	Iron	217-221	heme oxygenase 1	Rattus norvegicus	108-113
11302771-6	2001	In a rat model of radiation-induced nephropathy, we investigated changes in expression of heme oxygenase 1 (Hmox1, also known as HO-1), an enzyme that catalyzes conversion of heme into biliverdin, carbon monoxide and iron.	Iron	217-221	heme oxygenase 1	Rattus norvegicus	129-133
11328118-1	2001	We report on the first spin-resolved energy spectra for the emission of electrons during grazing scattering of 150 keV multicharged nitrogen ions from a magnetized Fe(001) surface.	Iron	164-166	spindlin 1	Homo sapiens	23-27
11451377-6	2001	The soluble ferrochelatase contained one mole of iron in each mole of the enzyme.	Iron	49-53	ferrochelatase	Homo sapiens	12-26
11120744-4	2001	The yeast genome contains five additional FRE1 and FRE2 homologues, four of which are regulated by iron and the major iron-dependent transcription factor, Aft1p, but whose function remains unknown.	Iron	118-122	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	155-160
11113132-13	2001	Taken together, our data strongly suggest that the product of the new liver-specific gene HEPC might play a specific role during iron overload and exhibit additional functions distinct from its antimicrobial activity.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	90-94
11238302-1	2001	BACKGROUND: Hereditary hyperferritinemia-cataract syndrome is an autosomic dominant disorder caused by heterogeneous mutations on the iron-responsive element (IRE) of ferritin L-chain mRNA.	Iron	134-138	ferritin light chain	Homo sapiens	167-183
11092880-0	2001	Characterization of an iron-dependent regulatory sequence involved in the transcriptional control of AtFer1 and ZmFer1 plant ferritin genes by iron.	Iron	23-27	ferritin-1, chloroplastic	Zea mays	112-118
11092880-0	2001	Characterization of an iron-dependent regulatory sequence involved in the transcriptional control of AtFer1 and ZmFer1 plant ferritin genes by iron.	Iron	143-147	ferritin-1, chloroplastic	Zea mays	112-118
11092880-4	2001	This Iron-Dependent Regulatory Sequence (IDRS) is responsible for transcriptional repression of ZmFer1 under low iron supply conditions.	Iron	5-9	ferritin-1, chloroplastic	Zea mays	96-102
11092880-4	2001	This Iron-Dependent Regulatory Sequence (IDRS) is responsible for transcriptional repression of ZmFer1 under low iron supply conditions.	Iron	113-117	ferritin-1, chloroplastic	Zea mays	96-102
11092880-5	2001	The IDRS is specific to the ZmFer1 iron-dependent regulation and does not mediate the antioxidant response that we have previously reported (Savino et al.	Iron	35-39	ferritin-1, chloroplastic	Zea mays	28-34
11159945-1	2001	The yeast frataxin homolog (Yfh1p) participates in mitochondrial iron homeostasis.	Iron	65-69	ferroxidase	Saccharomyces cerevisiae S288C	28-33
11159945-2	2001	The phenotypic defects of the Delta yfh1 mutant include drastic accumulation of iron in mitochondria and slow growth.	Iron	80-84	ferroxidase	Saccharomyces cerevisiae S288C	36-40
11146451-2	2001	We have studied the effect of orally administered iron-unsaturated bovine Lf on angiogenesis induced by VEGF(165) and IL-1-alpha in adult rats using the mesenteric-window angiogenesis assay.	Iron	50-54	vascular endothelial growth factor A	Bos taurus	104-108
11341946-0	2001	Effects of hyperoxia and iron on iron regulatory protein-1 activity and the ferritin synthesis in mouse peritoneal macrophages.	Iron	25-29	aconitase 1	Mus musculus	33-58
11341946-2	2001	In this paper, we have investigated the effect of hyperoxia and iron on the binding activity of IRP-1 and the ferritin synthesis in mouse peritoneal macrophages.	Iron	64-68	aconitase 1	Mus musculus	96-101
11341946-4	2001	Iron diminished the IRP-1-binding activity and the enhanced synthesis of ferritin.	Iron	0-4	aconitase 1	Mus musculus	20-25
11341946-6	2001	Consistently, hypoxia-induced loss of binding activity of IRP-1 and the enhanced synthesis of ferritin were blocked in the presence of an iron chelator deferoxamine.	Iron	138-142	aconitase 1	Mus musculus	58-63
11341946-7	2001	These alterations of the binding activity of IRP-1 in response to oxygen and iron were not reproduced in the cell-free extract.	Iron	77-81	aconitase 1	Mus musculus	45-50
11341946-8	2001	The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions.	Iron	52-56	aconitase 1	Mus musculus	98-103
11341946-8	2001	The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions.	Iron	177-181	aconitase 1	Mus musculus	98-103
11168438-2	2001	We have previously shown that patients with HH who have high iron stores have low numbers of circulating CD8+ T lymphocytes.	Iron	61-65	CD8a molecule	Homo sapiens	105-108
11168438-7	2001	Body iron stores correlated negatively with the number of CD8+ T lymphocytes in peripheral blood and in the liver, but not with the number in the small intestine.	Iron	5-9	CD8a molecule	Homo sapiens	58-61
11168438-9	2001	CONCLUSION: The results indicate that HH patients with the HFE C282Y mutation and low numbers of CD8+ cells in the liver lobuli have higher iron stores and are more prone to develop liver cirrhosis.	Iron	140-144	CD8a molecule	Homo sapiens	97-100
11167127-4	2001	Upon deletion of the homologous gene (YFH1) in the yeast, there was an accumulation of iron (Fe) within the mitochondrion.	Iron	93-95	ferroxidase	Saccharomyces cerevisiae S288C	38-42
11380187-0	2001	RDX degradation using an integrated Fe(0)-microbial treatment approach.	Iron	36-41	radixin	Homo sapiens	0-3
11380187-2	2001	This work presents proof of concept that permeable reactive iron barriers might be a viable approach to intercept and degrade RDX plumes.	Iron	60-64	radixin	Homo sapiens	126-129
11380187-3	2001	Specifically, RDX was rapidly reduced in aquifier microcosms amended with Fe(0) powder, and in flow-through columns packed with steel wool.	Iron	74-79	radixin	Homo sapiens	14-17
11380187-4	2001	The rate and extent of RDX degradation in microcosms was enhanced by anaerobic bacteria that feed on cathodic hydrogen (i.e., H2 produced during anaerobic Fe(0) corrosion by water).	Iron	155-157	radixin	Homo sapiens	23-26
11380187-5	2001	Apparently, the hydrogenotrophic consortium that exploits Fe(0) corrosion as a metabolic niche participated in the further degradation of heterocyclic intermediates produced by the reaction of RDX with Fe(0).	Iron	58-63	radixin	Homo sapiens	193-196
11380187-5	2001	Apparently, the hydrogenotrophic consortium that exploits Fe(0) corrosion as a metabolic niche participated in the further degradation of heterocyclic intermediates produced by the reaction of RDX with Fe(0).	Iron	202-207	radixin	Homo sapiens	193-196
11380187-6	2001	Reductive treatment of RDX with Fe(0) also reduced its toxicity to microorganisms and enhanced its subsequent biodegradability under either anaerobic or anaerobic conditions.	Iron	32-37	radixin	Homo sapiens	23-26
10978328-6	2000	A gel retardation assay of cytoplasmic extract from differentiated cells, using an iron-responsive element as a probe, revealed enhanced an RNA binding capacity of IRP1, which correlated with the increase of IRP1 mRNA.	Iron	83-87	aconitase 1	Mus musculus	164-168
10978328-6	2000	A gel retardation assay of cytoplasmic extract from differentiated cells, using an iron-responsive element as a probe, revealed enhanced an RNA binding capacity of IRP1, which correlated with the increase of IRP1 mRNA.	Iron	83-87	aconitase 1	Mus musculus	208-212
11069611-3	2000	Double immunofluorescent labelling for HO-1 and transferrin receptors revealed that HO-1-immunoreactive Schwann cells also expressed transferrin receptors suggesting activation of iron metabolism.	Iron	180-184	heme oxygenase 1	Rattus norvegicus	84-88
11063908-6	2000	A higher iron reduction and an increased LPO level determined by malondialdehyde HPLC measurement were also found in GGT-rel-overexpressing cells compared to GGT-rel negative cells.	Iron	9-13	inactive glutathione hydrolase 2	Homo sapiens	117-120
11063908-7	2000	Our data clearly indicate that in the presence of iron, not only GGT, but also GGT-rel has a pro-oxidant function by generation of a reactive metabolite (CysGly) and must be taken into account as a potential physiopathological oxidation system.	Iron	50-54	inactive glutathione hydrolase 2	Homo sapiens	65-68
11063908-7	2000	Our data clearly indicate that in the presence of iron, not only GGT, but also GGT-rel has a pro-oxidant function by generation of a reactive metabolite (CysGly) and must be taken into account as a potential physiopathological oxidation system.	Iron	50-54	gamma-glutamyltransferase 5	Homo sapiens	79-86
10922376-8	2000	Elevated copper levels induced the expression of the metallothioneins CUP1 and CRS5 and two genes, FET3 and FTR1, in the iron uptake system.	Iron	121-125	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	108-112
10922376-9	2000	Copper-induced FET3 and FTR1 expression arises from an indirect copper effect on cellular iron pools.	Iron	90-94	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	24-28
11030757-3	2000	Whereas the function of fxn is unknown, the yeast frataxin homolog (Yfh1p) has been shown to be involved in mitochondrial iron homeostasis and protection from free radical toxicity.	Iron	122-126	ferroxidase	Saccharomyces cerevisiae S288C	68-73
11030757-5	2000	We show that a wild-type FRDA cDNA can complement Yfh1p-deficient yeast (yfh1 delta) by preventing the mitochondrial iron accumulation and oxidative damage associated with loss of Yfh1p.	Iron	117-121	ferroxidase	Saccharomyces cerevisiae S288C	50-55
11030757-10	2000	These results demonstrate that fxn functions like Yfh1p, providing experimental support to the hypothesis that FRDA is a disorder of mitochondrial iron homeostasis.	Iron	147-151	ferroxidase	Saccharomyces cerevisiae S288C	50-55
11024540-1	2000	The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin.	Iron	96-100	heme oxygenase 1	Rattus norvegicus	11-27
11045759-5	2000	Iron overload as seen in hereditary hemochromatosis patients enhances suppressor T-cell (CD8) numbers and activity, decreases the proliferative capacity, numbers, and activity of helper T cells (CD4) with increases in CD8/CD4 ratios, impairs the generation of cytotoxic T cells, and alters immunoglobulin secretion when compared to treated hereditary hemochromatosis patients or controls.	Iron	0-4	CD8a molecule	Homo sapiens	89-92
11045759-5	2000	Iron overload as seen in hereditary hemochromatosis patients enhances suppressor T-cell (CD8) numbers and activity, decreases the proliferative capacity, numbers, and activity of helper T cells (CD4) with increases in CD8/CD4 ratios, impairs the generation of cytotoxic T cells, and alters immunoglobulin secretion when compared to treated hereditary hemochromatosis patients or controls.	Iron	0-4	CD8a molecule	Homo sapiens	218-221
11045759-6	2000	A correlation has recently been found between low CD8+ lymphocyte numbers, liver damage associated with HCV positivity, and severity of iron overload in beta-thalassemia major patients.	Iron	136-140	CD8a molecule	Homo sapiens	50-53
10942521-7	2000	In these conditions, compensatory upregulation of MnSOD may protect mitochondria from oxidative damage accruing from heme-derived free iron and carbon monoxide liberated by the activity of HO-1.	Iron	135-139	superoxide dismutase 2	Rattus norvegicus	50-55
10942521-7	2000	In these conditions, compensatory upregulation of MnSOD may protect mitochondria from oxidative damage accruing from heme-derived free iron and carbon monoxide liberated by the activity of HO-1.	Iron	135-139	heme oxygenase 1	Rattus norvegicus	189-193
10986467-6	2000	The proximal and distal histidine sidechains coordinate directly to the heme iron, forming a hemichrome with spectral properties similar to those of cytochrome b(5).	Iron	77-81	mitochondrially encoded cytochrome b	Homo sapiens	149-161
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	0-4	transferrin	Mus musculus	68-79
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	0-4	transferrin	Mus musculus	81-83
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	0-4	transferrin	Mus musculus	166-168
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	60-64	transferrin	Mus musculus	68-79
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	60-64	transferrin	Mus musculus	81-83
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	98-102	transferrin	Mus musculus	68-79
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	98-102	transferrin	Mus musculus	81-83
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	98-102	transferrin	Mus musculus	68-79
11062761-2	2000	Iron delivery to cells is accomplished by the complexing of iron to transferrin (Tf), a monomeric iron-binding protein in the plasma, followed by specific binding of Tf to cell-surface receptors, endocytosis of the receptor-ligand complexes and ultimately, release of iron from endosomal vesicles to the cytoplasm.	Iron	98-102	transferrin	Mus musculus	81-83
10811637-1	2000	Hemoglobin synthesis consumes most of the iron that is taken up by cells from plasma transferrin, and this process requires very high expression of transferrin receptors (TfR) at the membranes of erythroid cells.	Iron	42-46	transferrin	Mus musculus	85-96
10903501-0	2000	Regulation of the expression of human ferrochelatase by intracellular iron levels.	Iron	70-74	ferrochelatase	Homo sapiens	38-52
10903501-2	2000	To clarify the roles of the iron-sulfur cluster in the expression of mammalian ferrochelatase, enzyme activity in human erythroleukemia K562 cells under iron-depleted conditions was examined.	Iron	28-32	ferrochelatase	Homo sapiens	79-93
10903501-2	2000	To clarify the roles of the iron-sulfur cluster in the expression of mammalian ferrochelatase, enzyme activity in human erythroleukemia K562 cells under iron-depleted conditions was examined.	Iron	153-157	ferrochelatase	Homo sapiens	79-93
10903501-9	2000	When Escherichia coli ferrochelatase, which lacks the iron-sulfur cluster, was expressed in Cos7 cells, the activity did not change following any treatment.	Iron	54-58	ferrochelatase	Homo sapiens	22-36
10903501-11	2000	These results indicate that the expression of mammalian ferrochelatase is regulated by intracellular iron levels, via the iron-sulfur cluster center at the C-terminus, and this contributes to the regulation of the biosynthesis of heme at the terminal step.	Iron	101-105	ferrochelatase	Homo sapiens	56-70
10903501-11	2000	These results indicate that the expression of mammalian ferrochelatase is regulated by intracellular iron levels, via the iron-sulfur cluster center at the C-terminus, and this contributes to the regulation of the biosynthesis of heme at the terminal step.	Iron	122-126	ferrochelatase	Homo sapiens	56-70
11039663-8	2000	Analysis of these ALAS-E mutants unequivocally demonstrated that ALAS-E is the principal isozyme contributing to erythroid heme biosynthesis In ALAS-E-null mutant mouse embryos, erythroid differentiation was arrested, and an abnormal hematopoietic cell fraction emerged that accumulated a large amount of iron diffusely in the cytoplasm.	Iron	305-309	aminolevulinic acid synthase 2, erythroid	Mus musculus	65-71
11039663-8	2000	Analysis of these ALAS-E mutants unequivocally demonstrated that ALAS-E is the principal isozyme contributing to erythroid heme biosynthesis In ALAS-E-null mutant mouse embryos, erythroid differentiation was arrested, and an abnormal hematopoietic cell fraction emerged that accumulated a large amount of iron diffusely in the cytoplasm.	Iron	305-309	aminolevulinic acid synthase 2, erythroid	Mus musculus	65-71
10899298-11	2000	The iron chelator desferrioxamine (100 microM) in vitro prevented the aminoglycoside-induced reduction in relative expression of mRNA for both fimbrin and class III beta-tubulin.	Iron	4-8	plastin 1	Gallus gallus	143-150
10961154-0	2000	The effects of iron and copper status and of dietary carbohydrates on the activity of rat intestinal beta-carotene 15,15"-dioxygenase.	Iron	15-19	beta-carotene oxygenase 1	Rattus norvegicus	101-133
10748106-1	2000	In most cells, transferrin receptor (TfR1)-mediated endocytosis is a major pathway for cellular iron uptake.	Iron	96-100	transferrin receptor protein 1	Cricetulus griseus	15-35
10748106-1	2000	In most cells, transferrin receptor (TfR1)-mediated endocytosis is a major pathway for cellular iron uptake.	Iron	96-100	transferrin receptor protein 1	Cricetulus griseus	37-41
10748106-12	2000	In conclusion, TfR2 expression may be regulated by the cell cycle rather than cellular iron status and may support cell growth both in vitro and in vivo.	Iron	87-91	transferrin receptor protein 2	Cricetulus griseus	15-19
10816424-1	2000	We investigated the effect of oxalomalate (OMA, alpha-hydroxy-beta-oxalosuccinic acid), a competitive inhibitor of aconitase, on the RNA-binding activity of the iron-regulatory proteins (IRP1 and IRP2) that control the post-transcriptional expression of various proteins involved in iron metabolism.	Iron	161-165	aconitase 1	Mus musculus	187-191
10816424-6	2000	These findings suggest that the severe decrease in IRP1 RNA-binding activity depends on: (i) linking of OMA to the active site of aconitase, which prevents the switch to IRP1 and explains resistance to the reducing agents, and (ii) possible interaction of OMA with some functional amino acid residues in IRP that are responsible for binding to the specific mRNA sequences involved in the regulation of iron metabolism.	Iron	402-406	aconitase 1	Mus musculus	51-55
10923364-3	2000	Duodenal crypt cells of HFE-knockout mice show low intracellular iron concentrations which lead to an upregulation of the divalent metal transporter and enhanced iron uptake by duodenal enterocytes.	Iron	65-69	homeostatic iron regulator	Mus musculus	24-27
10923364-3	2000	Duodenal crypt cells of HFE-knockout mice show low intracellular iron concentrations which lead to an upregulation of the divalent metal transporter and enhanced iron uptake by duodenal enterocytes.	Iron	162-166	homeostatic iron regulator	Mus musculus	24-27
10748025-2	2000	A family of four putative transporters (Arn1p-4p) in Saccharomyces cerevisiae is expressed under conditions of iron deprivation and is regulated by Aft1p, the major iron-dependent transcription factor in yeast.	Iron	111-115	siderophore transporter	Saccharomyces cerevisiae S288C	40-45
10748025-2	2000	A family of four putative transporters (Arn1p-4p) in Saccharomyces cerevisiae is expressed under conditions of iron deprivation and is regulated by Aft1p, the major iron-dependent transcription factor in yeast.	Iron	111-115	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	148-153
10748025-2	2000	A family of four putative transporters (Arn1p-4p) in Saccharomyces cerevisiae is expressed under conditions of iron deprivation and is regulated by Aft1p, the major iron-dependent transcription factor in yeast.	Iron	165-169	siderophore transporter	Saccharomyces cerevisiae S288C	40-45
10748025-2	2000	A family of four putative transporters (Arn1p-4p) in Saccharomyces cerevisiae is expressed under conditions of iron deprivation and is regulated by Aft1p, the major iron-dependent transcription factor in yeast.	Iron	165-169	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	148-153
10748254-1	2000	Members of the ZIP gene family, a novel metal transporter family first identified in plants, are capable of transporting a variety of cations, including cadmium, iron, manganese and zinc.	Iron	162-166	death associated protein kinase 3	Homo sapiens	15-18
10872745-6	2000	Similarly, in the current study, amyloid-induced mitochondrial iron trapping was significantly attenuated by co-administration of the HO-1 transcriptional suppressor, dexamethasone (DEX) or the MTP blocker, cyclosporin A (CSA).	Iron	63-67	heme oxygenase 1	Rattus norvegicus	134-138
10764717-4	2000	Corrected total iron score (0-60) was defined by the sum of three scores: hepatocytic iron score (0-36), sinusoidal iron score (0-12), and portal iron score (0-12), multiplied by 3/3, 2/3, or 1/3 according to the heterogeneous iron localisation in the nodules.	Iron	16-20	olfactory receptor family 10 subfamily T member 2	Homo sapiens	179-195
10779357-12	2000	Twofold overexpression of Ssc1 partially suppresses the cold-sensitive growth phenotype of Deltassq1 cells, as well as the accumulation of mitochondrial iron and the defects in Fe/S enzyme activities normally found in Deltassq1 mitochondria.	Iron	153-157	Hsp70 family ATPase SSC1	Saccharomyces cerevisiae S288C	26-30
11019165-0	2000	Quasi-Ab initio molecular dynamic study of Fe melting We have investigated the melting of hcp Fe at high pressure by employing molecular dynamics simulations in conjunction with the full potential linear muffin tin orbital method.	Iron	43-45	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	90-93
10713071-5	2000	CCC1 expression in wild type cells resulted in increased expression of the high affinity iron transport system composed of FET3 and FTR1, suggesting that intracellular iron is not sensed by the iron-dependent transcription factor Aft1p.	Iron	168-172	Ccc1p	Saccharomyces cerevisiae S288C	0-4
10713071-5	2000	CCC1 expression in wild type cells resulted in increased expression of the high affinity iron transport system composed of FET3 and FTR1, suggesting that intracellular iron is not sensed by the iron-dependent transcription factor Aft1p.	Iron	168-172	Ccc1p	Saccharomyces cerevisiae S288C	0-4
10713071-6	2000	Introduction of AFT1(up), a constitutive allele of the iron transcription factor, AFT1, that also leads to increased high affinity iron transport did not prevent Deltayfh1 cells from becoming respiratory-incompetent.	Iron	55-59	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	16-20
10713071-6	2000	Introduction of AFT1(up), a constitutive allele of the iron transcription factor, AFT1, that also leads to increased high affinity iron transport did not prevent Deltayfh1 cells from becoming respiratory-incompetent.	Iron	55-59	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	82-86
10713071-6	2000	Introduction of AFT1(up), a constitutive allele of the iron transcription factor, AFT1, that also leads to increased high affinity iron transport did not prevent Deltayfh1 cells from becoming respiratory-incompetent.	Iron	131-135	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	16-20
10713071-6	2000	Introduction of AFT1(up), a constitutive allele of the iron transcription factor, AFT1, that also leads to increased high affinity iron transport did not prevent Deltayfh1 cells from becoming respiratory-incompetent.	Iron	131-135	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	82-86
10713071-7	2000	Although the mechanism by which CCC1 expression affects cytosolic iron is not known, the data suggest that excessive mitochondrial iron accumulation only occurs when cytosolic free iron levels are high.	Iron	66-70	Ccc1p	Saccharomyces cerevisiae S288C	32-36
10713071-7	2000	Although the mechanism by which CCC1 expression affects cytosolic iron is not known, the data suggest that excessive mitochondrial iron accumulation only occurs when cytosolic free iron levels are high.	Iron	131-135	Ccc1p	Saccharomyces cerevisiae S288C	32-36
10713071-7	2000	Although the mechanism by which CCC1 expression affects cytosolic iron is not known, the data suggest that excessive mitochondrial iron accumulation only occurs when cytosolic free iron levels are high.	Iron	131-135	Ccc1p	Saccharomyces cerevisiae S288C	32-36
10704227-1	2000	The iron-regulatory protein 1 (IRP1) regulates the expression of several molecules involved in iron (Fe) metabolism by reversibly binding to iron-responsive elements (IREs) in the untranslated regions (UTR) of particular mRNA transcripts.	Iron	4-8	aconitase 1	Mus musculus	31-35
10704227-1	2000	The iron-regulatory protein 1 (IRP1) regulates the expression of several molecules involved in iron (Fe) metabolism by reversibly binding to iron-responsive elements (IREs) in the untranslated regions (UTR) of particular mRNA transcripts.	Iron	101-103	aconitase 1	Mus musculus	4-29
10704227-1	2000	The iron-regulatory protein 1 (IRP1) regulates the expression of several molecules involved in iron (Fe) metabolism by reversibly binding to iron-responsive elements (IREs) in the untranslated regions (UTR) of particular mRNA transcripts.	Iron	101-103	aconitase 1	Mus musculus	31-35
10704227-1	2000	The iron-regulatory protein 1 (IRP1) regulates the expression of several molecules involved in iron (Fe) metabolism by reversibly binding to iron-responsive elements (IREs) in the untranslated regions (UTR) of particular mRNA transcripts.	Iron	95-99	aconitase 1	Mus musculus	4-29
10704227-1	2000	The iron-regulatory protein 1 (IRP1) regulates the expression of several molecules involved in iron (Fe) metabolism by reversibly binding to iron-responsive elements (IREs) in the untranslated regions (UTR) of particular mRNA transcripts.	Iron	95-99	aconitase 1	Mus musculus	31-35
10704227-3	2000	It has also been suggested that NO may act indirectly on IRP1 by affecting the intracellular Fe pools that regulate the function of this protein [Pantopoulous et al.	Iron	93-95	aconitase 1	Mus musculus	57-61
10704227-18	2000	Our results suggest that NO could activate IRP1 RNA-binding by two possible mechanisms: (1) its direct effect on the [4Fe-4S] cluster and (2) mobilization of (59)Fe from cells resulting in Fe depletion, which then increases IRP1 RNA-binding activity.	Iron	119-121	aconitase 1	Mus musculus	43-47
10704227-18	2000	Our results suggest that NO could activate IRP1 RNA-binding by two possible mechanisms: (1) its direct effect on the [4Fe-4S] cluster and (2) mobilization of (59)Fe from cells resulting in Fe depletion, which then increases IRP1 RNA-binding activity.	Iron	162-164	aconitase 1	Mus musculus	43-47
10702174-3	2000	OBJECTIVE: The objective of this study was to investigate the effect of supplementation with iron, zinc, or both on vitamin A and its metabolically related proteins retinol binding protein (RBP) and transthyretin.	Iron	93-97	retinol binding protein 4	Homo sapiens	165-188
10702174-3	2000	OBJECTIVE: The objective of this study was to investigate the effect of supplementation with iron, zinc, or both on vitamin A and its metabolically related proteins retinol binding protein (RBP) and transthyretin.	Iron	93-97	retinol binding protein 4	Homo sapiens	190-193
10702174-7	2000	Iron supplementation significantly increased plasma retinol, RBP, and transthyretin.	Iron	0-4	retinol binding protein 4	Homo sapiens	61-64
10730824-6	2000	Intraperitoneal injection of ferric nitrilotriacetate (Fe/NTA) caused an acute and remarkable increase in the level of thiobarbituric acid-reactive substances (TBARS) in both plasma and the liver, and also resulted in a considerable elevation of the plasma levels of GOT and GPT indicative of hepatic injury.	Iron	55-57	glutamic--pyruvic transaminase	Rattus norvegicus	275-278
10681454-0	2000	Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis.	Iron	75-79	transferrin receptor 2	Mus musculus	0-22
10681454-12	2000	From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.	Iron	82-86	transferrin receptor 2	Mus musculus	41-45
10681454-12	2000	From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.	Iron	144-148	transferrin receptor 2	Mus musculus	41-45
10681454-12	2000	From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.	Iron	144-148	transferrin receptor 2	Mus musculus	41-45
10644324-0	2000	Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload.	Iron	111-115	RoBo-1	Rattus norvegicus	16-44
10644324-0	2000	Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload.	Iron	111-115	RoBo-1	Rattus norvegicus	46-50
10644324-2	2000	Recently an iron carrier was cloned and named DMT1 (divalent metal transporter 1).	Iron	12-16	RoBo-1	Rattus norvegicus	46-50
10644324-2	2000	Recently an iron carrier was cloned and named DMT1 (divalent metal transporter 1).	Iron	12-16	RoBo-1	Rattus norvegicus	52-80
10639416-5	2000	Of these transformants, only B16B6(Str(r))/tbpA(ap)B(ap) could grow in the presence of porcine transferrin as the sole iron source, achieving a growth rate similar to that of the B16B6 parent strain in the presence of human transferrin.	Iron	119-123	transthyretin	Homo sapiens	43-47
10639416-5	2000	Of these transformants, only B16B6(Str(r))/tbpA(ap)B(ap) could grow in the presence of porcine transferrin as the sole iron source, achieving a growth rate similar to that of the B16B6 parent strain in the presence of human transferrin.	Iron	119-123	arginyl aminopeptidase	Homo sapiens	48-52
10713971-5	2000	Milk iron was linearly related to the serum iron:transferrin ratio in lactating mice whose serum iron ranged from 8 to 66 microM.	Iron	5-9	transferrin	Mus musculus	49-60
10713971-9	2000	The steady-state distribution ratio of 125I-transferrin between plasma and milk was about 0.2, indicating that transcytosed transferrin contributed a maximum of 6% of the milk iron.	Iron	176-180	transferrin	Mus musculus	124-135
10713971-13	2000	These experiments provide evidence that the initial and rate-limiting step in the transfer of iron into milk is binding to a basal transferrin receptor.	Iron	94-98	transferrin	Mus musculus	131-142
10865941-0	2000	Characterization of iron uptake from transferrin by murine endothelial cells.	Iron	20-24	transferrin	Mus musculus	37-48
10865941-4	2000	Cells were incubated with 59Fe-125I-Tf; Fe uptake was shown to increase linearly over time for both cell lines, while Tf uptake reached a plateau within 2 h. Both Tf and Fe uptake were saturable.	Iron	28-30	transferrin	Mus musculus	36-38
10865941-4	2000	Cells were incubated with 59Fe-125I-Tf; Fe uptake was shown to increase linearly over time for both cell lines, while Tf uptake reached a plateau within 2 h. Both Tf and Fe uptake were saturable.	Iron	40-42	transferrin	Mus musculus	36-38
10697391-0	2000	Discovery of the ceruloplasmin homologue hephaestin: new insight into the copper/iron connection.	Iron	81-85	hephaestin	Homo sapiens	41-51
10697391-2	2000	Discovery of hephaestin identifies a critical new component of the copper and iron connection in mammals.	Iron	78-82	hephaestin	Homo sapiens	13-23
10697391-3	2000	Hephaestin appears to be a multicopper oxidase required for efficient export of iron from the intestine.	Iron	80-84	hephaestin	Homo sapiens	0-10
10607459-2	1999	Iron ion exists in tap water because of dissolution from iron water pipes.	Iron	0-4	nuclear RNA export factor 1	Homo sapiens	19-22
10607459-2	1999	Iron ion exists in tap water because of dissolution from iron water pipes.	Iron	57-61	nuclear RNA export factor 1	Homo sapiens	19-22
10607459-3	1999	Iron ions in tap water cause discoloration and a bad odor.	Iron	0-4	nuclear RNA export factor 1	Homo sapiens	13-16
10567692-2	1999	This work examines the role and regulation of GPD1 and GPD2, encoding two isoforms of glycerol 3-phosphate dehydrogenase, in glycerol production during iron starvation.	Iron	152-156	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	46-50
10567692-5	1999	Deletion of either GPD1 or GPD2 alters the capacity for glycerol production during iron-limited as well as iron sufficient conditions.	Iron	83-87	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	19-23
10567692-5	1999	Deletion of either GPD1 or GPD2 alters the capacity for glycerol production during iron-limited as well as iron sufficient conditions.	Iron	107-111	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	19-23
10548545-1	1999	Haem oxygenase-1 (HO-1) is a highly inducible stress protein that removes haem from cells with the release of biliverdin, carbon monoxide and low-molecular-mass iron (LMrFe).	Iron	161-165	heme oxygenase 1	Rattus norvegicus	0-22
10557317-6	1999	Faithfully mimicking human hemochromatosis, mice homozygous for this deletion develop iron overload, characterized by a higher plasma iron content and a raised transferrin saturation as well as an elevated hepatic iron load.	Iron	86-90	transferrin	Mus musculus	160-171
10544286-0	1999	Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli.	Iron	109-113	hypothetical protein	Escherichia coli	29-33
10544286-2	1999	In Escherichia coli, genes in the ORF1-ORF2-iscS-iscU-iscA-hscB-hsc A-fdx-ORF3 cluster (the isc gene cluster) should be involved in the assembly of the Fe-S cluster since its coexpression with the reporter ferredoxin (Fd) dramatically increases the production of holoFd [Nakamura, M., Saeki, K., and Takahashi, Y.	Iron	152-156	hypothetical protein	Escherichia coli	39-43
10515803-5	1999	Our data suggest that an association exists between macrophage activation and hepatic dysfunction, and that iron status may affect the clinical course of HCV infection by modulating Th-1/Th-2 responses in vivo.	Iron	108-112	negative elongation factor complex member C/D	Homo sapiens	182-186
10592329-3	1999	Iron scarcity induces binding of IRPs to a single IRE in the 5"-UTR of ferritin, eALAS, aconitase and SDHb mRNAs, which specifically suppresses translation initiation.	Iron	0-4	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	102-106
10585494-1	1999	Fet3, the multicopper oxidase of yeast, oxidizes extracellular ferrous iron which is then transported into the cell through the permease Ftr1.	Iron	71-75	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	137-141
10498610-6	1999	Finally, although NO released by IFN-gamma/LPS-activated macrophages increased the iron-responsive element (IRE)-binding activity of both IRP1 and IRP2, IFN-gamma treatment decreased IRP2 activity in an NO-independent manner.	Iron	83-87	aconitase 1	Mus musculus	138-142
10498610-6	1999	Finally, although NO released by IFN-gamma/LPS-activated macrophages increased the iron-responsive element (IRE)-binding activity of both IRP1 and IRP2, IFN-gamma treatment decreased IRP2 activity in an NO-independent manner.	Iron	83-87	iron responsive element binding protein 2	Mus musculus	147-151
10506583-0	1999	Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron.	Iron	85-89	heme oxygenase 1	Rattus norvegicus	12-16
10935429-4	1999	In the US, the causes of death most commonly reported by the American Association of Poison Control Centers Toxic Exposure Surveillance System (AAPCC TESS) are carbon monoxide and adult formulations of iron.	Iron	202-206	testin LIM domain protein	Homo sapiens	150-154
10500204-4	1999	Frataxin function is still unknown but the knockout of the yeast frataxin homologue gene (YFH1) showed a severe defect of mitochondrial respiration and loss of mtDNA associated with elevated intramitochondrial iron.	Iron	210-214	ferroxidase	Saccharomyces cerevisiae S288C	90-94
10468587-11	1999	We suggest that NFU1 and ISU1 gene products play a role in iron homeostasis, perhaps in assembly, insertion, and/or repair of mitochondrial Fe-S clusters.	Iron	59-63	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	25-29
10468587-11	1999	We suggest that NFU1 and ISU1 gene products play a role in iron homeostasis, perhaps in assembly, insertion, and/or repair of mitochondrial Fe-S clusters.	Iron	140-144	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	25-29
10461992-0	1999	Phytase improves iron bioavailability for hemoglobin synthesis in young pigs.	Iron	17-21	putative glycerophosphoryl diester phosphodiesterase	Glycine max	0-7
10461992-2	1999	The efficacy of phytase in releasing phytate-bound Fe and P from soybean meal in vitro and in improving dietary Fe bioavailability for hemoglobin repletion in young, anemic pigs was examined.	Iron	51-53	putative glycerophosphoryl diester phosphodiesterase	Glycine max	16-23
10461992-2	1999	The efficacy of phytase in releasing phytate-bound Fe and P from soybean meal in vitro and in improving dietary Fe bioavailability for hemoglobin repletion in young, anemic pigs was examined.	Iron	112-114	putative glycerophosphoryl diester phosphodiesterase	Glycine max	16-23
10461992-15	1999	In conclusion, both sources of phytase effectively degraded phytate in corn-soy diets and subsequently released phytate-bound Fe from the diets for hemoglobin repletion in young, anemic pigs.	Iron	126-128	phytase	Zea mays	31-38
12038473-0	1999	Beta-carotene 15,15"-dioxygenase activity is responsive to copper and iron concentrations in rat small intestine.	Iron	70-74	beta-carotene oxygenase 1	Rattus norvegicus	0-32
12038473-1	1999	OBJECTIVE: Previous in vitro studies have suggested that beta-carotene 15,15"-dioxygenase is an iron-dependent enzyme.	Iron	96-100	beta-carotene oxygenase 1	Rattus norvegicus	57-89
12038473-5	1999	Our objective was to examine the effects of iron as affected by dietary copper on beta-carotene 15,15"-dioxygenase activity in the small intestine.	Iron	44-48	beta-carotene oxygenase 1	Rattus norvegicus	82-114
12038473-10	1999	In addition, intestinal beta-carotene 15,15"-dioxygenase activity was increased by 27% and 106%, respectively, for copper-deficient rats fed either normal or high iron diets, compared to the respective copper-adequate controls (p&lt;0.01).	Iron	163-167	beta-carotene oxygenase 1	Rattus norvegicus	24-56
12038473-13	1999	CONCLUSIONS: Intestinal beta-carotene 15,15"-dioxygenase may be an iron-dependent enzyme sensitive to copper status in vivo.	Iron	67-71	beta-carotene oxygenase 1	Rattus norvegicus	24-56
10415341-3	1999	It encodes the first domain only of the Nad11 polypeptide, i.e. a 23-kDa, FeS-binding domain instead of the usual 75/80-kDa protein found in the mitochondrial or alpha-proteobacterial complex I enzymes.	Iron	74-77	nad11	Pylaiella littoralis	40-45
10397746-4	1999	Ligand 311 was far more active than DFO at increasing Fe release from SK-N-MC neuroepithelioma and BE-2 neuroblastoma cells and preventing Fe uptake from transferrin.	Iron	139-141	transferrin	Mus musculus	154-165
10413471-6	1999	Addition of ascorbate reduces not only the iron of cytochrome f to the ferrous low-spin state (delta = 0.43 mm/s, DeltaE(Q) = 1.12 mm/s at 4.2 K) but also the bis-histidine coordinated iron of the Rieske 2Fe-2S center to the ferrous high-spin state (delta(2) = 0.73 mm/s, DeltaE(Q2) = -2.95 mm/s at 4.2 K).	Iron	43-47	apocytochrome f precursor	Spinacia oleracea	51-63
10413471-6	1999	Addition of ascorbate reduces not only the iron of cytochrome f to the ferrous low-spin state (delta = 0.43 mm/s, DeltaE(Q) = 1.12 mm/s at 4.2 K) but also the bis-histidine coordinated iron of the Rieske 2Fe-2S center to the ferrous high-spin state (delta(2) = 0.73 mm/s, DeltaE(Q2) = -2.95 mm/s at 4.2 K).	Iron	185-189	apocytochrome f precursor	Spinacia oleracea	51-63
10373684-2	1999	The classical concept for iron uptake into mammalian cells has been the endocytosis of transferrin-bound Fe3+ by the transferrin receptor.	Iron	26-30	transferrin	Mus musculus	117-128
10425724-2	1999	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis suggested the molecular mass of Korean native goat lactoferrin is 82 kDa with an iron saturation of 30% as estimated by spectroscopic analysis.	Iron	165-169	lactotransferrin	Capra hircus	135-146
10336882-9	1999	Proposed functions for the oxidoreductase include stimulation of cell growth, reduction of the ascorbate free radical outside cells, recycling of alpha-tocopherol, reduction of lipid hydroperoxides, and reduction of ferric iron prior to iron uptake by a transferrin-independent pathway.	Iron	223-227	thioredoxin reductase 1	Homo sapiens	27-41
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	121-125	ferroxidase	Saccharomyces cerevisiae S288C	66-70
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	121-125	ferroxidase	Saccharomyces cerevisiae S288C	77-82
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	195-199	ferroxidase	Saccharomyces cerevisiae S288C	66-70
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	195-199	ferroxidase	Saccharomyces cerevisiae S288C	77-82
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	195-199	ferroxidase	Saccharomyces cerevisiae S288C	66-70
10332043-2	1999	In Saccharomyces cerevisiae, lack of the yeast frataxin homolog ( YFH1 gene, Yfh1p polypeptide) results in mitochondrial iron accumulation, suggesting that frataxin is required for mitochondrial iron homeostasis and that FRDA results from oxidative damage secondary to mitochondrial iron overload.	Iron	195-199	ferroxidase	Saccharomyces cerevisiae S288C	77-82
10332043-4	1999	We show that Yfh1p interacts functionally with yeast mitochondrial intermediate peptidase ( OCT1 gene, YMIP polypeptide), a metalloprotease required for maturation of ferrochelatase and other iron-utilizing proteins.	Iron	192-196	ferroxidase	Saccharomyces cerevisiae S288C	13-18
10332043-6	1999	Accordingly, YMIP is active and promotes mitochondrial iron accumulation in a mutant lacking Yfh1p ( yfh1 [Delta]), while genetic inactivation of YMIP in this mutant ( yfh1 [Delta] oct1 [Delta]) leads to a 2-fold reduction in mitochondrial iron levels.	Iron	240-244	ferroxidase	Saccharomyces cerevisiae S288C	168-172
10332043-7	1999	Moreover, overexpression of Yfh1p restores mitochondrial iron homeostasis and YMIP activity in a conditional oct1 ts mutant, but does not affect iron levels in a mutant completely lacking YMIP ( oct1 [Delta]).	Iron	57-61	ferroxidase	Saccharomyces cerevisiae S288C	28-33
10332043-8	1999	Thus, we propose that Yfh1p maintains mitochondrial iron homeostasis both directly, by promoting iron export, and indirectly, by regulating iron levels and therefore YMIP activity, which promotes mitochondrial iron uptake.	Iron	52-56	ferroxidase	Saccharomyces cerevisiae S288C	22-27
10332043-8	1999	Thus, we propose that Yfh1p maintains mitochondrial iron homeostasis both directly, by promoting iron export, and indirectly, by regulating iron levels and therefore YMIP activity, which promotes mitochondrial iron uptake.	Iron	97-101	ferroxidase	Saccharomyces cerevisiae S288C	22-27
10332043-8	1999	Thus, we propose that Yfh1p maintains mitochondrial iron homeostasis both directly, by promoting iron export, and indirectly, by regulating iron levels and therefore YMIP activity, which promotes mitochondrial iron uptake.	Iron	97-101	ferroxidase	Saccharomyces cerevisiae S288C	22-27
10332043-8	1999	Thus, we propose that Yfh1p maintains mitochondrial iron homeostasis both directly, by promoting iron export, and indirectly, by regulating iron levels and therefore YMIP activity, which promotes mitochondrial iron uptake.	Iron	97-101	ferroxidase	Saccharomyces cerevisiae S288C	22-27
10229861-3	1999	By means of this and subsequent DNase I footprinting analysis we identified a regulatory region between -153 and -142 bp upstream of the transcriptional start site of the iNOS promoter that was sensitive to regulation by iron perturbation.	Iron	221-225	deoxyribonuclease I	Mus musculus	32-39
10341420-3	1999	They both encode for plasma membrane ferric/cupric reductases and their expression is regulated by iron and copper availability, mediated by the transcription factors Aft1p and Mac1p, respectively.	Iron	99-103	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	167-172
10194372-7	1999	These findings suggest that protein B may alter the positioning but not the availability of coordination sites on iron for exogenous ligand binding and reactivity.	Iron	114-118	prolyl 3-hydroxylase 3	Homo sapiens	28-37
10208657-7	1999	The brain clearly displayed the greatest susceptibility to spontaneous and Fe-stimulated lipid peroxidation, was highly unsaturated and contained very low levels of vitamin E, no detectable carotenoids, low GSH-Px, and low CAT activity.	Iron	75-77	catalase	Gallus gallus	223-226
10077651-2	1999	We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron.	Iron	223-227	homeostatic iron regulator	Mus musculus	26-29
10077651-2	1999	We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron.	Iron	223-227	homeostatic iron regulator	Mus musculus	177-180
10077651-2	1999	We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron.	Iron	318-322	homeostatic iron regulator	Mus musculus	26-29
10077651-2	1999	We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron.	Iron	318-322	homeostatic iron regulator	Mus musculus	177-180
10077651-4	1999	By 4 weeks of age, the HFE-/- mice demonstrated iron loading when compared with HFE+/+ littermates, with elevated transferrin saturations (68.4% vs. 49.8%) and elevated liver iron concentrations (985 micrograms vs. 381 micrograms).	Iron	48-52	homeostatic iron regulator	Mus musculus	23-26
10077651-4	1999	By 4 weeks of age, the HFE-/- mice demonstrated iron loading when compared with HFE+/+ littermates, with elevated transferrin saturations (68.4% vs. 49.8%) and elevated liver iron concentrations (985 micrograms vs. 381 micrograms).	Iron	175-179	homeostatic iron regulator	Mus musculus	23-26
10077651-7	1999	HFE-/- mice also demonstrated an increase in duodenal DMT1(IRE) mRNA (average 7.7-fold), despite their elevated transferrin saturation and hepatic iron content.	Iron	147-151	homeostatic iron regulator	Mus musculus	0-3
10077651-9	1999	These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron.	Iron	98-102	homeostatic iron regulator	Mus musculus	45-48
10077651-9	1999	These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron.	Iron	211-215	homeostatic iron regulator	Mus musculus	45-48
10049497-3	1999	Lipid peroxidation and protein kinase C (PK-C) activation were observed during the apoptosis of C6 cells, and these events were inhibited by antioxidants and iron chelators without affecting BSO-induced GSH depletion.	Iron	158-162	protein kinase C, gamma	Rattus norvegicus	23-39
10049497-3	1999	Lipid peroxidation and protein kinase C (PK-C) activation were observed during the apoptosis of C6 cells, and these events were inhibited by antioxidants and iron chelators without affecting BSO-induced GSH depletion.	Iron	158-162	protein kinase C, gamma	Rattus norvegicus	41-45
9973309-4	1999	More recently, studies of the role of C-13 hydroxy metabolites of anthracyclines have provided new perspectives on the role of iron in the cardiotoxicity of these drugs, showing that such metabolites can impair intracellular iron handling and homeostasis.	Iron	127-131	homeobox C13	Homo sapiens	38-42
9930764-1	1999	Studies on iron uptake into the brain have traditionally focused on transport by transferrin.	Iron	11-15	transferrin	Mus musculus	81-92
9930764-2	1999	However, transferrin receptors are not found in all brain regions and are especially low in white matter tracts where high iron concentrations have been reported.	Iron	123-127	transferrin	Mus musculus	9-20
9930764-10	1999	The distribution of ferritin binding sites in brain vis-a-vis transferrin receptor distribution suggests distinct methods for iron delivery between gray and white matter.	Iron	126-130	transferrin	Mus musculus	62-73
10048761-0	1999	Iron increases manganese superoxide dismutase activity in intestinal epithelial cells.	Iron	0-4	superoxide dismutase 2	Rattus norvegicus	15-45
10048761-6	1999	The present study was designed to use a cell culture model to further investigate the effect of supplemental iron on MnSOD production and activity.	Iron	109-113	superoxide dismutase 2	Rattus norvegicus	117-122
10048761-9	1999	MnSOD protein levels and activity were determined in the lipid and iron treated cells following treatment with TNF.	Iron	67-71	superoxide dismutase 2	Rattus norvegicus	0-5
10048761-12	1999	Iron supplementation increased MnSOD protein levels and activity in the non-TNF treated cells but did not influence the ability of TNF to induce MnSOD in IEC-6 cells.	Iron	0-4	superoxide dismutase 2	Rattus norvegicus	31-36
10048761-13	1999	Findings indicate that supplemental iron may increase MnSOD due to increased oxidative stress but does not compromise the ability of inflammatory mediators to further increase the activity of this enzyme.	Iron	36-40	superoxide dismutase 2	Rattus norvegicus	54-59
10473284-2	1999	These rats have a mutation in Divalent Metal Transporter 1, which has been implicated in iron transport from endosomes.	Iron	89-93	RoBo-1	Rattus norvegicus	30-58
10473284-8	1999	The results of this study indicate that Divalent Metal Transporter 1 is important to iron transport in the brain.	Iron	85-89	RoBo-1	Rattus norvegicus	40-68
9874215-2	1998	Class I alpha2beta2 RNRs contain a dinuclear iron center and an essential tyrosyl radical in the beta2 component (protein R2).	Iron	45-49	hemoglobin, beta adult minor chain	Mus musculus	14-19
9813017-8	1998	Homologues of Ssq1p and Jac1p are found in bacteria in close association with genes proposed to be involved in iron-sulfur protein biosynthesis.	Iron	111-115	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	24-29
9813017-12	1998	Taken together these results suggest a role for Ssq1p, Jac1p, and Nfs1p in assembly/maturation of mitochondrial iron-sulfur proteins and that one or more of the target Fe/S proteins contribute to oxidative damage in cells lacking copper/zinc SOD.	Iron	112-116	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	55-60
9811853-2	1998	gef1 mutants have a defect in the high-affinity iron transport system, which relies on the cell surface multicopper oxidase Fet3p.	Iron	48-52	Gef1p	Saccharomyces cerevisiae S288C	0-4
9784581-2	1998	Zrt1, Zrt2 and Zip1-4 are probably zinc transporters in Saccharomyces cerevisiae and Arabidopsis thaliana whereas Irt1 appears to play a role in iron uptake in A. thaliana.	Iron	145-149	iron-regulated transporter 1	Arabidopsis thaliana	114-118
9850571-0	1998	Transferrin response in normal and iron-deficient mice heterozygotic for hypotransferrinemia; effects on iron and manganese accumulation.	Iron	35-39	transferrin	Mus musculus	0-11
9850571-0	1998	Transferrin response in normal and iron-deficient mice heterozygotic for hypotransferrinemia; effects on iron and manganese accumulation.	Iron	105-109	transferrin	Mus musculus	0-11
9850571-2	1998	These mice provide a unique opportunity to examine the developmental pattern and response of Tf to iron-deficient diets, and furthermore, to address the controversial role of Tf in Mn transport.	Iron	99-103	transferrin	Mus musculus	93-95
9850571-7	1998	These results imply that either there is a selected targeting of iron to the brain by plasma Tf or there is an alternative iron delivery system to the brain.	Iron	65-69	transferrin	Mus musculus	93-95
9734404-4	1998	The anti-inflammatory properties of HO-1 are thought to rely on the ability of this enzyme to degrade heme and generate bilirubin, free iron and carbon monoxide.	Iron	136-140	heme oxygenase 1	Rattus norvegicus	36-40
9694900-6	1998	This transport protein also displays an REXXE motif resembling domains involved in iron binding by ferritin and in iron uptake mediated by the yeast transporter Ftr1.	Iron	83-87	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	161-165
9694900-6	1998	This transport protein also displays an REXXE motif resembling domains involved in iron binding by ferritin and in iron uptake mediated by the yeast transporter Ftr1.	Iron	115-119	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	161-165
9681959-1	1998	Heme oxygenase, catalyses oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase and then specifically cleaves heme into biliverdin, carbon monoxide, and iron.	Iron	178-182	cytochrome p450 oxidoreductase	Rattus norvegicus	73-104
9639532-1	1998	Ferrochelatase catalyzes the chelation of ferrous iron and protoporphyrin to form heme.	Iron	42-54	ferrochelatase	Homo sapiens	0-14
9621303-1	1998	Cell-specific expression of the iron-binding protein transferrin is in part mediated through the regulation of its promoter.	Iron	32-36	transferrin	Mus musculus	53-64
9611262-5	1998	YIpDCE1 has been used to create strains simultaneously overexpressing the permease (FTR1) and oxidase (FET3) components of the yeast high-affinity iron uptake system.	Iron	147-151	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	84-88
9596665-1	1998	Hereditary hyperferritinemia-cataract syndrome (HHCS) is an autosomal and dominant disease caused by heterogeneous mutations in the iron responsive element (IRE) of the 5" untranslated flanking region of ferritin L-chain mRNA, which reduce the binding to the trans iron regulatory proteins and make L-chain synthesis constitutively upregulated.	Iron	132-136	ferritin light chain	Homo sapiens	204-220
9596665-1	1998	Hereditary hyperferritinemia-cataract syndrome (HHCS) is an autosomal and dominant disease caused by heterogeneous mutations in the iron responsive element (IRE) of the 5" untranslated flanking region of ferritin L-chain mRNA, which reduce the binding to the trans iron regulatory proteins and make L-chain synthesis constitutively upregulated.	Iron	265-269	ferritin light chain	Homo sapiens	204-220
9660175-2	1998	When bound to iron-responsive elements (IRE), IRP-1 post-transcriptionally regulates the expression of mRNAs involved in iron metabolism.	Iron	14-18	Iron regulatory protein 1A	Drosophila melanogaster	46-51
9660175-2	1998	When bound to iron-responsive elements (IRE), IRP-1 post-transcriptionally regulates the expression of mRNAs involved in iron metabolism.	Iron	121-125	Iron regulatory protein 1A	Drosophila melanogaster	46-51
9560297-0	1998	Iron loading of isolated rat hepatocytes inhibits asialoglycoprotein receptor dynamics and induces formation of rat hepatic lectin-1 [correction of leptin-1] (RHL-1) oligomers.	Iron	0-4	asialoglycoprotein receptor 1	Rattus norvegicus	116-132
9560297-0	1998	Iron loading of isolated rat hepatocytes inhibits asialoglycoprotein receptor dynamics and induces formation of rat hepatic lectin-1 [correction of leptin-1] (RHL-1) oligomers.	Iron	0-4	asialoglycoprotein receptor 1	Rattus norvegicus	159-164
9560297-1	1998	The major subunit [rat hepatic lectin-1 (RHL-1)] of the asialoglycoprotein (ASGP) receptor mediates endocytosis of the iron-binding protein lactoferrin (Lf) by isolated rat hepatocytes, yet iron loading of cultured adult rat hepatocytes increases the binding and endocytosis of Lf while greatly inhibiting the uptake of desialylated ligand.	Iron	119-123	asialoglycoprotein receptor 1	Rattus norvegicus	23-46
9560297-2	1998	In the present study, we determined whether the iron-induced Lf-binding site is RHL-1 and examined the nature of the iron-induced block in ASGP receptor endocytic function.	Iron	48-52	asialoglycoprotein receptor 1	Rattus norvegicus	80-85
9560297-6	1998	ASOR and anti-RHL-1 sera blocked the binding and endocytosis of 125I-Lf on control cells but not on iron-loaded cells, indicating that the iron-induced Lf-binding site on hepatocytes is not RHL-1.	Iron	139-143	asialoglycoprotein receptor 1	Rattus norvegicus	14-19
9560297-9	1998	Under these conditions, we found an iron-dependent evolution of 88 and 140 kDa RHL-1-containing, beta-mercaptoethanol-sensitive multimers that constituted up to 34 and 23%, respectively, of total immunodetectable RHL-1.	Iron	36-40	asialoglycoprotein receptor 1	Rattus norvegicus	79-84
9560297-9	1998	Under these conditions, we found an iron-dependent evolution of 88 and 140 kDa RHL-1-containing, beta-mercaptoethanol-sensitive multimers that constituted up to 34 and 23%, respectively, of total immunodetectable RHL-1.	Iron	36-40	asialoglycoprotein receptor 1	Rattus norvegicus	213-218
9560297-10	1998	We propose that iron-induced formation of cystinyl-linked RHL-1-containing multimers inhibits ASGP receptor movement between cell surface and interior and disrupts acylation of intracellular receptors.	Iron	16-20	asialoglycoprotein receptor 1	Rattus norvegicus	58-63
9657286-12	1998	In Vit A + Ni treated mice, compared to Ni-treated mice, hepatic Fe was significantly increased while Cu, Zn and Ca levels were reduced, but still higher than those of control and Vit A-treated mice.	Iron	65-67	vitrin	Mus musculus	3-6
9585058-8	1998	Further, BPO-mediated induction in ornithine decarboxylase (ODC) activity and [3H]thymidine incorporation in cutaneous DNA were higher in the iron overload group.	Iron	142-146	ornithine decarboxylase, structural 1	Mus musculus	35-58
9585058-8	1998	Further, BPO-mediated induction in ornithine decarboxylase (ODC) activity and [3H]thymidine incorporation in cutaneous DNA were higher in the iron overload group.	Iron	142-146	ornithine decarboxylase, structural 1	Mus musculus	60-63
9585058-9	1998	In addition, in iron-overloaded mice, cutaneous lipid peroxidation (LPO) and xanthine oxidase (XOD) activities were higher, whereas catalase activity was reduced.	Iron	16-20	xanthine dehydrogenase	Mus musculus	77-93
9531620-2	1998	Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (beta2m-/-) mice, that fail to express MHC class I products, develop iron overload.	Iron	190-194	homeostatic iron regulator	Mus musculus	40-43
9535853-7	1998	This is followed by redox equilibration of CuB with Fea/CuA or Fea3 (in which Fea and Fea3 are the iron centers of cytochromes a and a3, respectively).	Iron	99-103	FEA	Homo sapiens	63-66
15810310-2	1998	This results obtained indicate that high amounts of Mn, Fe and Mg are embodied in Bean and Bean-products.	Iron	56-58	brain expressed associated with NEDD4 1	Homo sapiens	82-86
15810310-2	1998	This results obtained indicate that high amounts of Mn, Fe and Mg are embodied in Bean and Bean-products.	Iron	56-58	brain expressed associated with NEDD4 1	Homo sapiens	91-95
9520490-1	1998	A defect in the yeast GEF1 gene, a CLC chloride channel homolog leads to an iron requirement and cation sensitivity.	Iron	76-80	Gef1p	Saccharomyces cerevisiae S288C	22-26
9482913-4	1998	To test the hypothesis that the HFE gene is involved in regulation of iron homeostasis, we studied the effects of a targeted disruption of the murine homologue of the HFE gene.	Iron	70-74	homeostatic iron regulator	Mus musculus	32-35
9482913-7	1998	Stainable hepatic iron in the HFE mutant mice was predominantly in hepatocytes in a periportal distribution.	Iron	18-22	homeostatic iron regulator	Mus musculus	30-33
9482913-10	1998	This study shows that the HFE protein is involved in the regulation of iron homeostasis and that mutations in this gene are responsible for HH.	Iron	71-75	homeostatic iron regulator	Mus musculus	26-29
9498842-1	1998	The heme oxygenase-1 gene, HO-1, induced by heme, ischemia, and heat shock, metabolizes heme to biliverdin, free iron, and carbon monoxide.	Iron	113-117	heme oxygenase 1	Rattus norvegicus	4-20
9498842-1	1998	The heme oxygenase-1 gene, HO-1, induced by heme, ischemia, and heat shock, metabolizes heme to biliverdin, free iron, and carbon monoxide.	Iron	113-117	heme oxygenase 1	Rattus norvegicus	27-31
9623801-3	1998	It contains two low-spin cytochromes (c and b), and a high-spin cytochrome b which forms a binuclear center with a non-heme iron.	Iron	124-128	mitochondrially encoded cytochrome b	Homo sapiens	64-76
9464259-5	1998	TRP2 requires zinc as its metal ligand, and small amounts of iron bound to TRP2; TRP1 did not bind copper, zinc or iron.	Iron	61-65	dopachrome tautomerase	Homo sapiens	75-79
9781347-1	1998	Lactoferrin is a member of the transferrin family of iron-binding proteins to which several physiological functions have been ascribed.	Iron	53-57	transferrin	Mus musculus	31-42
9428699-2	1997	Uptake of transferrin and iron doubled 24 h after exposure to erythropoietin, due to a twofold rise in surface transferrin receptors.	Iron	26-30	transferrin	Mus musculus	111-122
9428699-3	1997	In addition, a tenfold increase in iron incorporation into haem was observed after erythropoietin stimulation, as iron taken up from transferrin was directed towards haem biosynthesis and away from storage in ferritin.	Iron	35-39	transferrin	Mus musculus	133-144
9428699-3	1997	In addition, a tenfold increase in iron incorporation into haem was observed after erythropoietin stimulation, as iron taken up from transferrin was directed towards haem biosynthesis and away from storage in ferritin.	Iron	114-118	transferrin	Mus musculus	133-144
9434348-6	1997	The inability of these same vacuolar mutant strains to repress FET3 mRNA levels in the presence of an iron-unresponsive allele of the AFT1 regulatory gene are consistent with alterations in the intracellular distribution of redox states of Fe3+/2+ in the presence of elevated extracellular concentrations of copper ions.	Iron	102-106	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	134-138
9335289-1	1997	Transferrin-binding protein B (TbpB) from Neisseria meningitidis binds human transferrin (hTf) at the surface of the bacterial cell as part of the iron uptake process.	Iron	147-151	transferrin	Mus musculus	0-11
9341986-0	1997	Alteration in the organ distribution of iron by truncated transferrin: implications for iron chelation therapy.	Iron	40-44	transferrin	Mus musculus	58-69
9341986-0	1997	Alteration in the organ distribution of iron by truncated transferrin: implications for iron chelation therapy.	Iron	88-92	transferrin	Mus musculus	58-69
9341986-1	1997	The ability of the partial molecule of transferrin, truncated transferrin (t-Tf), to act as an excretable biologic iron chelator was examined.	Iron	115-119	transferrin	Mus musculus	39-50
9341986-1	1997	The ability of the partial molecule of transferrin, truncated transferrin (t-Tf), to act as an excretable biologic iron chelator was examined.	Iron	115-119	transferrin	Mus musculus	62-73
9341986-5	1997	Injection of iron 59-labeled transferrin results in the deposition of iron in the major hematopoetic organs of mice such as the spleen, bone marrow, and liver.	Iron	13-17	transferrin	Mus musculus	29-40
9341986-5	1997	Injection of iron 59-labeled transferrin results in the deposition of iron in the major hematopoetic organs of mice such as the spleen, bone marrow, and liver.	Iron	70-74	transferrin	Mus musculus	29-40
11669951-0	1997	Spin Crossover in Novel Dihydrobis(1-pyrazolyl)borate [H(2)B(pz)(2)]-Containing Iron(II) Complexes.	Iron	80-84	spindlin 1	Homo sapiens	0-4
11669951-8	1997	The structural modifications associated with the spin change in 2 mainly consist of a large reorganization of the metal environment: the Fe-N decreases by 0.15 A (mean value) when the temperature is lowered from 290 to 139 K and a more regular shape of the [FeN(6)] octahedron is achieved through a slight modification of the trigonal deformation angle from 5.3 degrees to 3.2 degrees along with remarkable variations of the N-Fe-N angles.	Iron	137-141	spindlin 1	Homo sapiens	49-53
11669951-8	1997	The structural modifications associated with the spin change in 2 mainly consist of a large reorganization of the metal environment: the Fe-N decreases by 0.15 A (mean value) when the temperature is lowered from 290 to 139 K and a more regular shape of the [FeN(6)] octahedron is achieved through a slight modification of the trigonal deformation angle from 5.3 degrees to 3.2 degrees along with remarkable variations of the N-Fe-N angles.	Iron	137-139	spindlin 1	Homo sapiens	49-53
9252675-5	1997	In the pathological evolution of iron overload to a neoplasia, the probable involvement of an iron exchange between iron complexes from non-transferrin-bound iron of plasma and ATP is discussed.	Iron	94-98	transferrin	Mus musculus	140-151
9252675-5	1997	In the pathological evolution of iron overload to a neoplasia, the probable involvement of an iron exchange between iron complexes from non-transferrin-bound iron of plasma and ATP is discussed.	Iron	94-98	transferrin	Mus musculus	140-151
9110217-6	1997	Hemoglobin status was obtained by injecting 3-d-old barrows with 100 (low) or 200 mg (high) of Fe.	Iron	95-97	HGB	Sus scrofa	0-10
9325434-6	1997	In fact, recent studies have demonstrated that the membrane-bound Tf homologue, MTf, can bind and internalize Fe from 59Fe-citrate.	Iron	110-112	metallothionein 1L, pseudogene	Homo sapiens	80-83
9110146-4	1997	This study shows that treatment of Jurkat cells with iron chelator deferoxamine (DFO) strongly decreases HIV-1 Tat-potentiated TNF-induced NF-kappa B activation but does not modify NF-kappa B activation by TNF-alpha.	Iron	53-57	Tat	Human immunodeficiency virus 1	111-114
9110146-12	1997	in the presence of iron ions play a major role in HIV-1 Tat enhancement of TNF-induced NF-kappa B activation and that iron chelation may protect Jurkat T cells, at least in part, against oxidative stress induced by Tat.	Iron	19-23	Tat	Human immunodeficiency virus 1	56-59
9106510-9	1997	Induction of the TPSI1 gene appears to be a response specific to Pi starvation since it is not affected by starvation of other nutrients (nitrogen, potassium and iron).	Iron	162-166	TPSI1	Solanum lycopersicum	17-22
9009306-7	1997	This Lbp was only present when H. pylori was grown in an iron-starved medium, suggesting that it serves in iron uptake.	Iron	57-61	lipopolysaccharide binding protein	Homo sapiens	5-8
9009306-7	1997	This Lbp was only present when H. pylori was grown in an iron-starved medium, suggesting that it serves in iron uptake.	Iron	107-111	lipopolysaccharide binding protein	Homo sapiens	5-8
9039823-1	1997	Iron regulatory protein 1 (IRP1) and IRP2 are cytoplasmic RNA binding proteins that coordinate cellular iron homeostasis in mammals.	Iron	104-108	iron responsive element binding protein 2	Rattus norvegicus	37-41
9039823-4	1997	RNA binding activity of IRP1 and IRP2 was enhanced one- to twofold in rats fed 11 or 2 mg iron/kg diet compared with control rats.	Iron	90-94	iron responsive element binding protein 2	Rattus norvegicus	33-37
15093378-0	1997	Removal of TNT and RDX from water and soil using iron metal.	Iron	49-59	radixin	Homo sapiens	19-22
9119254-7	1997	In GGT-rich HepG2 human hepatoma cells, the exposure to GSH, glycyl-glycine, and ADP-chelated iron resulted in a nontoxic lipid peroxidation process, which could be prevented by means of GGT inhibitors such as acivicin and the serine-boric acid complex.	Iron	94-98	inactive glutathione hydrolase 2	Homo sapiens	3-6
9119254-7	1997	In GGT-rich HepG2 human hepatoma cells, the exposure to GSH, glycyl-glycine, and ADP-chelated iron resulted in a nontoxic lipid peroxidation process, which could be prevented by means of GGT inhibitors such as acivicin and the serine-boric acid complex.	Iron	94-98	inactive glutathione hydrolase 2	Homo sapiens	187-190
8985227-6	1997	These data are consistent with the hypothesis that iron chelation therapy in children with cerebral malaria strengthens Th1-mediated immune effector function involving increased production of NO.	Iron	51-55	negative elongation factor complex member C/D	Homo sapiens	120-123
8930792-10	1996	Subsequently, iron may be linked to brain transferrin synthesized within oligodendrocytes and choroid plexus epithelial cells followed by a concomitant uptake of iron-transferrin in neurons expressing transferrin receptors.	Iron	14-18	transferrin	Mus musculus	42-53
8930792-10	1996	Subsequently, iron may be linked to brain transferrin synthesized within oligodendrocytes and choroid plexus epithelial cells followed by a concomitant uptake of iron-transferrin in neurons expressing transferrin receptors.	Iron	14-18	transferrin	Mus musculus	167-178
8930792-10	1996	Subsequently, iron may be linked to brain transferrin synthesized within oligodendrocytes and choroid plexus epithelial cells followed by a concomitant uptake of iron-transferrin in neurons expressing transferrin receptors.	Iron	14-18	transferrin	Mus musculus	167-178
8930792-10	1996	Subsequently, iron may be linked to brain transferrin synthesized within oligodendrocytes and choroid plexus epithelial cells followed by a concomitant uptake of iron-transferrin in neurons expressing transferrin receptors.	Iron	162-166	transferrin	Mus musculus	167-178
8930792-10	1996	Subsequently, iron may be linked to brain transferrin synthesized within oligodendrocytes and choroid plexus epithelial cells followed by a concomitant uptake of iron-transferrin in neurons expressing transferrin receptors.	Iron	162-166	transferrin	Mus musculus	167-178
8901787-2	1996	Those receiving iron showed increases in hemoglobin (8 g/L), ferritin (3.7 micrograms/L), and the acute-phase protein alpha 1-antichymotrypsin (ACT; 0.06 g/L).	Iron	16-20	serpin family A member 3	Homo sapiens	118-142
8892964-3	1996	H and L ferritin subunits assemble in various proportions to form a 24-subunit protein shell which can store up to 4500 iron atoms.	Iron	120-124	ferritin light polypeptide 1	Mus musculus	6-16
8823161-8	1996	To provide an independent measure of the accuracy of the model for the oxidized protein, the expected pseudocontact shifts induced by the spin 1/2 iron were compared to the observed redox-dependent chemical shift changes.	Iron	147-151	spindlin 1	Equus caballus	138-146
8873230-1	1996	The oral iron chelator deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one, DMHP, LT or CP20) can be a useful drug in patients with transfusional hemosiderosis.	Iron	9-13	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	84-88
8643627-2	1996	The IRT1 (iron-regulated transporter) gene of the plant Arabidopsis thaliana, encoding a probable Fe(II) transporter, was cloned by functional expression in a yeast strain defective for iron uptake.	Iron	10-14	iron-regulated transporter 1	Arabidopsis thaliana	4-8
8643627-7	1996	In Arabidopsis, IRT1 is expressed in roots, is induced by iron deficiency, and has altered regulation in plant lines bearing mutations that affect the iron uptake system.	Iron	58-62	iron-regulated transporter 1	Arabidopsis thaliana	16-20
8722913-8	1996	A size polymorphism in the PCR production derived from iron response element binding protein (IREBP) distinguished the JF from the WL allele.	Iron	55-59	aconitase 1, soluble	Gallus gallus	94-99
8835393-2	1996	FSH can modulate the majority of Sertoli cell differentiated functions, including stimulation of the iron-binding protein transferrin.	Iron	101-105	transferrin	Mus musculus	122-133
8573077-11	1996	From the present data, the existence of additional ligands for metal ions other than zinc in the DCT molecule, such as the proposed cysteine iron-binding sites, cannot be completely ruled out.	Iron	141-145	dopachrome tautomerase	Homo sapiens	97-100
8821649-1	1996	When grown in vivo, or under iron-restriction in vitro, Neisseria meningitidis expresses a number of iron-regulated outer membrane proteins, including two transferrin-binding proteins (Tbp1 and Tbp2).	Iron	101-105	EGFLAM antisense RNA 3	Homo sapiens	185-189
7500944-11	1995	Our results are consistent with a pathway leading from chorismate to isochorismate and then to salicylate plus pyruvate, catalyzed consecutively by the iron-repressible PchA and PchB proteins in P. aeruginosa.	Iron	152-156	isochorismate-pyruvate lyase	Pseudomonas aeruginosa PAO1	178-182
8585058-3	1995	On day eight the hemoglobin concentrations obtained by early postnatal iron administration were higher than the values after the usual iron injection on the third day of life.	Iron	71-75	HGB	Sus scrofa	17-27
8585058-3	1995	On day eight the hemoglobin concentrations obtained by early postnatal iron administration were higher than the values after the usual iron injection on the third day of life.	Iron	135-139	HGB	Sus scrofa	17-27
9979929-0	1995	Spin-resolved iron surface density of states.	Iron	14-18	spindlin 1	Homo sapiens	0-4
7720678-1	1995	The heme oxygenase isozymes, HO-1 and HO-2, oxidatively cleave the heme molecule to produce antioxidants, the bile pigments, the gaseous cellular messenger, CO, and iron, a regulator of transferrin, ferritin, and nitric oxide synthase gene expression.	Iron	165-169	heme oxygenase 1	Rattus norvegicus	29-42
7665160-5	1995	CLCN3 protein also shows a high similarity with GEF1, an integral membrane protein of the yeast Saccharomyces cerevisiae known to be involved in respiration and iron-limited cell growth, and with the predicted protein product of a DNA sequence from the mold Septoria nodorum.	Iron	161-165	Gef1p	Saccharomyces cerevisiae S288C	48-52
7636015-11	1995	Presumably, Tf transports the iron found in Hp oligodendrocytes.	Iron	30-34	transferrin	Mus musculus	12-14
9977429-0	1995	Spin-polarized-electron scattering studies of the Fe bilayer on W(100): Theory and experiment.	Iron	50-52	spindlin 1	Homo sapiens	0-4
7867079-0	1995	Iron differentially modulates the CD4-lck and CD8-lck complexes in resting peripheral blood T-lymphocytes.	Iron	0-4	CD8a molecule	Homo sapiens	46-49
7867079-8	1995	This differential effect of ferric citrate on the CD4+ and CD8+ T-cell subsets led to a marked decrease in the CD4/CD8 ratios in iron-treated PBLs after the 20- to 24-hr period (P &lt; 0.001).	Iron	129-133	CD8a molecule	Homo sapiens	59-62
7867079-8	1995	This differential effect of ferric citrate on the CD4+ and CD8+ T-cell subsets led to a marked decrease in the CD4/CD8 ratios in iron-treated PBLs after the 20- to 24-hr period (P &lt; 0.001).	Iron	129-133	CD8a molecule	Homo sapiens	115-118
7849292-1	1995	Transferrin (Tf) plays an important role during immunologic activation by donating iron to activated lymphocytes.	Iron	83-87	transferrin	Mus musculus	0-11
7849292-1	1995	Transferrin (Tf) plays an important role during immunologic activation by donating iron to activated lymphocytes.	Iron	83-87	transferrin	Mus musculus	13-15
7867783-0	1995	The effect of iron status on glyceraldehyde 3-phosphate dehydrogenase expression in rat liver.	Iron	14-18	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	29-69
7867783-1	1995	The influence of iron status on glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene transcription, mRNA levels and distribution was determined in whole liver samples from adult Wistar rats.	Iron	17-21	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	32-72
7867783-1	1995	The influence of iron status on glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene transcription, mRNA levels and distribution was determined in whole liver samples from adult Wistar rats.	Iron	17-21	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	74-79
7822035-5	1995	Some isolates of A. pleuropneumoniae were able to use hemoglobin from various animal species as well as other heme compounds as sole sources of iron for growth, while other isolates were unable to use them.	Iron	144-148	HGB	Sus scrofa	54-64
7822035-12	1995	Binding of hemoglobin to LPS might represent an important means by which A. pleuropneumoniae acquires iron in vivo from hemoglobin released from erythrocytes lysed by the action of its hemolysins.	Iron	102-106	HGB	Sus scrofa	11-21
7822035-12	1995	Binding of hemoglobin to LPS might represent an important means by which A. pleuropneumoniae acquires iron in vivo from hemoglobin released from erythrocytes lysed by the action of its hemolysins.	Iron	102-106	HGB	Sus scrofa	120-130
7827055-2	1995	Photoexcitation of Ru(II) in the 1:1 Ru-27-CC:CcP complex results in formation of a metal-to-ligand charge-transfer state, Ru(II*), which is a strong reducing agent and rapidly transfers an electron to the CC heme Fe(III) with rate constant k1 = 2.3 x 10(7) s-1.	Iron	214-216	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	46-49
8821326-8	1995	The fluorophores from ROS peroxidized with ferrous iron have different properties from the lipofuscin in human RPE extracted with the organic solvents.	Iron	43-55	ribulose-5-phosphate-3-epimerase	Homo sapiens	111-114
7744374-0	1995	[An experimental study on the protective effect of hepatocyte growth factor (HGF) for the primary cultured hepatocytes obtained from iron-loaded rats].	Iron	133-137	hepatocyte growth factor	Rattus norvegicus	51-75
7744374-0	1995	[An experimental study on the protective effect of hepatocyte growth factor (HGF) for the primary cultured hepatocytes obtained from iron-loaded rats].	Iron	133-137	hepatocyte growth factor	Rattus norvegicus	77-80
7744374-5	1995	The damage of iron-loaded hepatocytes induced by CCl4 was more serious than that of control, and HGF decreased this injury only in iron-loaded hepatocytes but not in control.	Iron	14-18	hepatocyte growth factor	Rattus norvegicus	97-100
7591532-4	1995	Pulmonary ODC and SAT activities showed increasing tendency on feeding excess iron for 28 weeks.	Iron	78-82	ornithine decarboxylase, structural 1	Mus musculus	10-13
8583875-10	1995	CONCLUSION: T2-QMRI measurement of T2 relaxation time is more accurate than SI ratios in evaluating liver iron overload.	Iron	106-110	solute carrier family 25 member 5	Homo sapiens	12-19
7999760-4	1994	The coordination of the iron(II) in native lipoxygenase changes when methanol (as low as 0.1%) or glycerol (20%) is added to the buffer prior to freezing.	Iron	24-28	linoleate 9S-lipoxygenase-4	Glycine max	43-55
7999760-9	1994	The iron coordination in iron(III) lipoxygenase is less affected by the presence of alcohols than is the site in the iron(II) enzyme.	Iron	4-8	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7999760-9	1994	The iron coordination in iron(III) lipoxygenase is less affected by the presence of alcohols than is the site in the iron(II) enzyme.	Iron	25-29	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7857832-1	1994	Erythropoietic protoporphyria (EPP) is an inherited inborn error of porphyrin metabolism caused by decreased activity of the enzyme ferrochelatase, the terminal enzyme of the haem biosynthetic pathway, which catalyses the insertion of iron into protoporphyrin to form haem.	Iron	235-239	ferrochelatase	Homo sapiens	132-146
7712294-1	1994	The haem biosynthesis pathway continues to provide surprises, from the first enzyme, 5-aminolaevulinic acid synthase, the mRNA of which contains an iron-responsive element, to the last, ferrochelatase, that contains an iron sulphur cluster.	Iron	219-223	ferrochelatase	Homo sapiens	186-200
9975706-0	1994	Spin-resolved photoemission from Pt/Fe(001).	Iron	36-38	spindlin 1	Homo sapiens	0-4
8053671-2	1994	While mitochondrial superoxide dismutase (Mn-SOD) scavenges superoxide anions to prevent damage of mtDNA, excess amount of reactive oxygen generated by quinone compounds impairs the mtDNA, in which involvement of iron ion-catalyzed reactions is suggested.	Iron	213-217	superoxide dismutase 2	Rattus norvegicus	42-48
8200975-11	1994	Thus, superoxide-mediated, iron-catalyzed formation of hydroxyl radicals can rapidly and irreversibly inactivate PAF acetylhydrolase.	Iron	27-31	phospholipase A2 group VII	Homo sapiens	113-132
8131214-2	1994	In the present work, iron (FeC6H5O7) and zinc (ZnCl2) were tested in comparison to nickel (NiCl2) and cobalt (CoCl2) for their effect on six different surface molecules known to be involved in recognition and activation processes, namely CD4, CD2, CD3, CD8, HLA-ABC, and HLA-DR. Iron was seen to down-modulate expression of the CD4 and the CD2 molecules on the surface of T-lymphocytes, as indicated by a decrease in the mean fluorescence intensity measured by FACS analysis.	Iron	21-25	CD8a molecule	Homo sapiens	253-256
8308010-9	1994	Specifically, the recombinant ferrochelatase has iron and porphyrin as substrates, and N-methylprotoporphyrin and metal ions (e.g. Hg2+ and Mn2+), as strong inhibitors of its enzyme activity.	Iron	49-53	ferrochelatase	Homo sapiens	30-44
8167428-3	1994	The OMP profiles of most bacterial strains grown under usual conditions, or in the Fe-supplemented medium, contained four major bands of approximately 31, 45, 63-66 and 97 kDa, and in addition, a number of minor bands.	Iron	83-85	olfactory marker protein	Homo sapiens	4-7
8167428-4	1994	It was found that OMP from 10 of 13 strains tested and grown on iron deficient medium contained an intensive band of a protein in the molecular weight region of 76 kDa which was lacking in the OMP of bacteria grown in the presence of iron (iron-regulated protein).	Iron	64-68	olfactory marker protein	Homo sapiens	18-21
8167428-4	1994	It was found that OMP from 10 of 13 strains tested and grown on iron deficient medium contained an intensive band of a protein in the molecular weight region of 76 kDa which was lacking in the OMP of bacteria grown in the presence of iron (iron-regulated protein).	Iron	234-238	olfactory marker protein	Homo sapiens	18-21
8167428-4	1994	It was found that OMP from 10 of 13 strains tested and grown on iron deficient medium contained an intensive band of a protein in the molecular weight region of 76 kDa which was lacking in the OMP of bacteria grown in the presence of iron (iron-regulated protein).	Iron	234-238	olfactory marker protein	Homo sapiens	18-21
8262972-2	1993	IRF controls expression of ferritin and transferrin receptor post-transcriptionally via specific binding to stem-loop iron-responsive elements (IREs) located in the untranslated regions of the respective mRNAs.	Iron	118-122	transferrin	Mus musculus	40-51
8244265-1	1993	Protoporphyria is a genetic disorder characterized by a defect in the enzyme ferrochelatase, which catalyzes the chelation of iron to protoporphyrin.	Iron	126-130	ferrochelatase	Homo sapiens	77-91
8395516-12	1993	The potentials of both the 2Fe/2S centers in XDH were determined and found to be identical to the values which were found for the iron-sulfur centers in XO.	Iron	130-134	xanthine dehydrogenase	Bos taurus	45-48
7504626-2	1993	We examined the effect of NO on the activity of iron regulatory factor (IRF), a cytoplasmic protein which modulates both ferritin mRNA translation and transferrin receptor mRNA stability by binding to specific mRNA sequences called iron responsive elements (IREs).	Iron	48-52	transferrin	Mus musculus	151-162
8373741-3	1993	The immobilized transferrin was stable without decomposition over 48 h and showed higher activities of cell growth acceleration than free transferrin and transported ferric ion as effectively as free transferrin.	Iron	166-176	transferrin	Mus musculus	16-27
8335628-6	1993	Orf2 is a transmembrane redox protein with four iron-sulfur clusters, as indicated by its similarity to DmsB from Escherichia coli.	Iron	48-52	hypothetical protein	Escherichia coli	0-4
8335628-8	1993	Orf6 is a cytoplasmic redox protein containing two iron-sulfur clusters, as indicated by its similarity to the ferredoxin domain of [Fe] hydrogenase from Desulfovibrio species.	Iron	51-55	hypothetical protein	Escherichia coli	0-4
10006776-0	1993	Spin-resolved photoemission study of the clean and oxygen-covered Fe(110) surface.	Iron	66-68	spindlin 1	Homo sapiens	0-4
8500913-0	1993	Relationship between loss of pigmentation and deletion of the chromosomal iron-regulated irp2 gene in Yersinia pestis: evidence for separate but related events.	Iron	74-78	iron responsive element binding protein 2	Mus musculus	89-93
8478396-7	1993	Basic fibroblast growth factor (bFGF), nerve growth factor (NGF), and insulin-like growth factors (IGF-I and IGF-II) each protected neurons against iron-induced damage.	Iron	148-152	insulin-like growth factor 2	Rattus norvegicus	109-115
7763459-1	1993	The elucidation of the relationship of the structure of human serum transferrin to its iron-binding activity and the delineation of the interactions between transferrin and its receptor will require the construction and production of site-specific mutants of human serum transferrin to test the importance of specific structural motifs to the functions of transferrin.	Iron	87-91	serotransferrin	Mesocricetus auratus	68-79
8427986-0	1993	Transferrin synthesis by mouse lymph node and peritoneal macrophages: iron content and effect on lymphocyte proliferation.	Iron	70-74	transferrin	Mus musculus	0-11
8427986-1	1993	Transferrin is an essential requirement for lymphocyte proliferation, because it supplies activated lymphocytes with iron needed for cell proliferation.	Iron	117-121	transferrin	Mus musculus	0-11
8427986-2	1993	However, during inflammation or an immune response, the iron content of circulating transferrin, which is of hepatic origin, decreases.	Iron	56-60	transferrin	Mus musculus	84-95
8427986-3	1993	It is hypothesized that activated lymphocytes may therefore obtain transferrin-iron from an alternative source, and we have investigated the possibility that transferrin is synthesized locally in lymphoid tissues.	Iron	79-83	transferrin	Mus musculus	67-78
8427986-5	1993	Transferrin synthesized by mouse lymph node or peritoneal macrophages contained iron and was able to promote mouse lymphocyte proliferation.	Iron	80-84	transferrin	Mus musculus	0-11
8427986-6	1993	Peritoneal macrophages activated in vivo synthesized more transferrin, released more transferrin-bound iron, and were more effective than resident macrophages at enhancing lymphocyte proliferation.	Iron	103-107	transferrin	Mus musculus	85-96
7678569-1	1993	Expression of the iron transport gene, fatB and fatA, in the bacterium Vibrio anguillarum 775 is negatively regulated by the iron concentration in the medium.	Iron	18-22	ferric anguibactin transport protein	Vibrio anguillarum 775	39-43
7678569-1	1993	Expression of the iron transport gene, fatB and fatA, in the bacterium Vibrio anguillarum 775 is negatively regulated by the iron concentration in the medium.	Iron	18-22	ferric anguibactin receptor	Vibrio anguillarum 775	48-52
7678569-1	1993	Expression of the iron transport gene, fatB and fatA, in the bacterium Vibrio anguillarum 775 is negatively regulated by the iron concentration in the medium.	Iron	125-129	ferric anguibactin transport protein	Vibrio anguillarum 775	39-43
7678569-1	1993	Expression of the iron transport gene, fatB and fatA, in the bacterium Vibrio anguillarum 775 is negatively regulated by the iron concentration in the medium.	Iron	125-129	ferric anguibactin receptor	Vibrio anguillarum 775	48-52
7678569-2	1993	Here, we show that iron represses fatB and fatA mRNA levels and concomitantly induces the synthesis of an antisense RNA (RNA alpha).	Iron	19-23	ferric anguibactin transport protein	Vibrio anguillarum 775	34-38
7678569-2	1993	Here, we show that iron represses fatB and fatA mRNA levels and concomitantly induces the synthesis of an antisense RNA (RNA alpha).	Iron	19-23	ferric anguibactin receptor	Vibrio anguillarum 775	43-47
7678569-3	1993	The presence of RNA alpha correlates with the inhibition of FatA protein synthesis and thus may play a role in the iron repression of fatA expression.	Iron	115-119	ferric anguibactin receptor	Vibrio anguillarum 775	60-64
7678569-3	1993	The presence of RNA alpha correlates with the inhibition of FatA protein synthesis and thus may play a role in the iron repression of fatA expression.	Iron	115-119	ferric anguibactin receptor	Vibrio anguillarum 775	134-138
7678569-4	1993	Since the 5" end of RNA alpha maps 125 nucleotides upstream from the start codon of fatA and this RNA also extends into the coding region of fatB, it may also be involved in the iron regulation of fatB expression.	Iron	178-182	ferric anguibactin receptor	Vibrio anguillarum 775	84-88
7678569-4	1993	Since the 5" end of RNA alpha maps 125 nucleotides upstream from the start codon of fatA and this RNA also extends into the coding region of fatB, it may also be involved in the iron regulation of fatB expression.	Iron	178-182	ferric anguibactin transport protein	Vibrio anguillarum 775	141-145
7678569-4	1993	Since the 5" end of RNA alpha maps 125 nucleotides upstream from the start codon of fatA and this RNA also extends into the coding region of fatB, it may also be involved in the iron regulation of fatB expression.	Iron	178-182	ferric anguibactin transport protein	Vibrio anguillarum 775	197-201
8416300-0	1993	A concise review: iron absorption--the mucin-mobilferrin-integrin pathway.	Iron	18-22	solute carrier family 13 member 2	Rattus norvegicus	39-44
8416301-1	1993	The ferrous iron of hemoglobin is exposed continuously to high concentrations of oxygen and, thereby, is oxidized slowly to methemoglobin, a protein unable to carry oxygen.	Iron	12-16	hemoglobin subunit gamma 2	Homo sapiens	124-137
8386494-8	1993	These results suggest that the increased formation of conjugated dienes and/or hydroperoxyl (or peroxyl) groups in PUFA molecules is relevant to the cancer cell-killing effect of GLA+Fe.	Iron	183-185	pumilio RNA binding family member 3	Homo sapiens	115-119
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	52-56	transferrin	Mus musculus	73-84
8417963-6	1993	With the HPO-iron complexes, addition of sufficient iron to saturate the transferrin in the medium reversed the inhibitory effects of the relatively hydrophilic CP20-iron complex but not those of the more lipophilic CP94-iron complex.	Iron	52-56	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	161-165
8417963-7	1993	Addition of further iron-saturated transferrin also corrected inhibition by the CP94-iron complex.	Iron	20-24	transferrin	Mus musculus	35-46
8417963-7	1993	Addition of further iron-saturated transferrin also corrected inhibition by the CP94-iron complex.	Iron	85-89	transferrin	Mus musculus	35-46
8417963-9	1993	The difference in the relative effects of CP20 to CP94 on hemopoiesis in vivo and in vitro suggests that additional factors to those inhibiting hemopoiesis in marrow cultures may operate with the long-term administration of iron chelators in vivo.	Iron	224-228	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	42-46
8444516-1	1993	ITF 282 is an iron succinyl casein complex containing 5% iron.	Iron	14-18	trefoil factor 3	Rattus norvegicus	0-3
1288876-6	1992	In addition to protoporphyrin synthesis the supply of another substrate, iron, is decisive for the gene expression ferrochelatase.	Iron	73-77	ferrochelatase	Mus musculus	115-129
1288876-7	1992	Iron chelators (desferrioxamine or pyridoxal isonicotinoylhydrazone) reduced and iron donors (iron bound to transferrin or pyridoxal isonicotinoylhydrazone) enhanced mRNA synthesis for ferrochelatase.	Iron	0-4	ferrochelatase	Mus musculus	185-199
1288876-7	1992	Iron chelators (desferrioxamine or pyridoxal isonicotinoylhydrazone) reduced and iron donors (iron bound to transferrin or pyridoxal isonicotinoylhydrazone) enhanced mRNA synthesis for ferrochelatase.	Iron	81-85	transferrin	Mus musculus	108-119
1466901-4	1992	Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.	Iron	52-56	transferrin	Mus musculus	19-30
21584613-0	1992	Intracellular free Fatty-Acid release and lipid-peroxidation in cultured human breast-cancer cells in response to gamma-linolenic Acid with iron (gla + fe).	Iron	140-144	galactosidase alpha	Homo sapiens	146-149
21584613-7	1992	These results suggest an association of intracellular FFA release with the peroxidation of PUFA and the cancer cell-killing by GLA in the presence of iron.	Iron	150-154	galactosidase alpha	Homo sapiens	127-130
1332761-10	1992	The excellent agreement between model compounds and isolated Cyt b559 reinforces the validity of the model of a heme iron coordinated to two histidine residues for Cyt b559.	Iron	117-121	mitochondrially encoded cytochrome b	Homo sapiens	61-66
1332763-10	1992	Despite the hexacoordination of the heme iron in this form, the bimolecular rate constant is approximately 22% that of pentacoordinate wild-type yeast cytochrome c peroxidase.	Iron	41-45	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	151-174
1450923-4	1992	Iron and transferrin uptake into the brain and CSF decreased with increasing age and was greater in the iron-deficient than in the control 21-day rats.	Iron	104-108	colony stimulating factor 2	Rattus norvegicus	47-50
1450923-5	1992	The quantity of 125I-transferrin recovered in the CSF could account for only a small proportion of the iron taken up by the brain.	Iron	103-107	colony stimulating factor 2	Rattus norvegicus	50-53
1417929-4	1992	When CP20 and CP94 were administered to the ferrocene-loaded rat model in combination with an iron-free diet there were significant decreases in (i) total homogenate iron and (ii) hepatic ferritin iron when compared to the iron-loaded rat receiving the iron-free diet alone.	Iron	94-98	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	5-9
1417929-4	1992	When CP20 and CP94 were administered to the ferrocene-loaded rat model in combination with an iron-free diet there were significant decreases in (i) total homogenate iron and (ii) hepatic ferritin iron when compared to the iron-loaded rat receiving the iron-free diet alone.	Iron	166-170	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	5-9
1417929-4	1992	When CP20 and CP94 were administered to the ferrocene-loaded rat model in combination with an iron-free diet there were significant decreases in (i) total homogenate iron and (ii) hepatic ferritin iron when compared to the iron-loaded rat receiving the iron-free diet alone.	Iron	166-170	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	5-9
1417929-4	1992	When CP20 and CP94 were administered to the ferrocene-loaded rat model in combination with an iron-free diet there were significant decreases in (i) total homogenate iron and (ii) hepatic ferritin iron when compared to the iron-loaded rat receiving the iron-free diet alone.	Iron	166-170	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	5-9
1417929-4	1992	When CP20 and CP94 were administered to the ferrocene-loaded rat model in combination with an iron-free diet there were significant decreases in (i) total homogenate iron and (ii) hepatic ferritin iron when compared to the iron-loaded rat receiving the iron-free diet alone.	Iron	166-170	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	5-9
1325837-10	1992	The signal intensity was concentration dependent, suggesting that the g = 3.2 signal is characteristic of the low-spin heme iron in cyt b-558.	Iron	124-128	cytochrome b	Sus scrofa	132-137
1522598-0	1992	Crystallization and crystallographic characterization of the iron-sulfur-containing DNA-repair enzyme endonuclease III from Escherichia coli.	Iron	61-65	endonuclease III	Escherichia coli	102-118
1522598-1	1992	Endonuclease III from Escherichia coli is an iron-sulfur enzyme possessing both DNA N-glycosylase and apurinic/apyrimidinic lyase activities.	Iron	45-49	endonuclease III	Escherichia coli	0-16
1522598-8	1992	The elucidation of endonuclease III structure will facilitate not only the understanding of glycosylase and lyase mechanisms but also the structure and function of this new class of iron-sulfur proteins.	Iron	182-186	endonuclease III	Escherichia coli	19-35
1444386-9	1992	The virulent isolates produced high titers of hemolysin, were resistant to inactivation by serum complement, produced phenolate siderophore, and utilized transferrin-bound iron.	Iron	172-176	transferrin	Mus musculus	154-165
1444386-11	1992	The avirulent isolates differed from those of the other two classes in their inability to either produce significant amounts of phenolate siderophore or utilize transferrin-bound iron.	Iron	179-183	transferrin	Mus musculus	161-172
1444386-12	1992	A modified agar plate diffusion method for transferrin-bound iron utilization was developed to differentiate the two classes of virulent isolates from the avirulent isolates in vitro.	Iron	61-65	transferrin	Mus musculus	43-54
1618766-6	1992	Present results show that CO and O2 bindings to the heme iron of Mb are controlled by Leu29(B10) by influencing the structure of close vicinity of the heme and the geometry of iron-bound ligand.	Iron	57-61	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	92-95
1618766-6	1992	Present results show that CO and O2 bindings to the heme iron of Mb are controlled by Leu29(B10) by influencing the structure of close vicinity of the heme and the geometry of iron-bound ligand.	Iron	176-180	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	92-95
1633843-10	1992	The results suggest that DT is a metal-containing glycosylated enzyme, possibly with ferrous iron at its catalytic center.	Iron	93-97	dopachrome tautomerase	Mus musculus	25-27
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	Iron	334-338	spindlin 1	Homo sapiens	19-23
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	Iron	334-338	spindlin 1	Homo sapiens	34-38
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	Iron	334-338	spindlin 1	Homo sapiens	34-38
1731957-0	1992	Uptake and intracellular handling of iron from transferrin and iron chelates by mitogen stimulated mouse lymphocytes.	Iron	37-41	transferrin	Mus musculus	47-58
1731957-2	1992	Iron uptake from transferrin by proliferating lymphocytes gradually increased as saturation of the protein with iron was increased up to 100%, but rose sharply when addition of further iron resulted in the presence of non-transferrin bound iron.	Iron	0-4	transferrin	Mus musculus	17-28
1731957-2	1992	Iron uptake from transferrin by proliferating lymphocytes gradually increased as saturation of the protein with iron was increased up to 100%, but rose sharply when addition of further iron resulted in the presence of non-transferrin bound iron.	Iron	0-4	transferrin	Mus musculus	222-233
1731957-2	1992	Iron uptake from transferrin by proliferating lymphocytes gradually increased as saturation of the protein with iron was increased up to 100%, but rose sharply when addition of further iron resulted in the presence of non-transferrin bound iron.	Iron	112-116	transferrin	Mus musculus	17-28
1731957-2	1992	Iron uptake from transferrin by proliferating lymphocytes gradually increased as saturation of the protein with iron was increased up to 100%, but rose sharply when addition of further iron resulted in the presence of non-transferrin bound iron.	Iron	185-189	transferrin	Mus musculus	17-28
1731957-2	1992	Iron uptake from transferrin by proliferating lymphocytes gradually increased as saturation of the protein with iron was increased up to 100%, but rose sharply when addition of further iron resulted in the presence of non-transferrin bound iron.	Iron	185-189	transferrin	Mus musculus	17-28
1731957-3	1992	Increasing the saturation of transferrin with iron caused an increased rate of proliferation up to about 100% saturation but when the level of iron present exceeded the binding capacity of the protein, proliferation decreased and at high levels of iron it was reduced below that seen in the absence of transferrin.	Iron	46-50	transferrin	Mus musculus	29-40
1731957-3	1992	Increasing the saturation of transferrin with iron caused an increased rate of proliferation up to about 100% saturation but when the level of iron present exceeded the binding capacity of the protein, proliferation decreased and at high levels of iron it was reduced below that seen in the absence of transferrin.	Iron	143-147	transferrin	Mus musculus	29-40
1731957-3	1992	Increasing the saturation of transferrin with iron caused an increased rate of proliferation up to about 100% saturation but when the level of iron present exceeded the binding capacity of the protein, proliferation decreased and at high levels of iron it was reduced below that seen in the absence of transferrin.	Iron	143-147	transferrin	Mus musculus	302-313
1731957-3	1992	Increasing the saturation of transferrin with iron caused an increased rate of proliferation up to about 100% saturation but when the level of iron present exceeded the binding capacity of the protein, proliferation decreased and at high levels of iron it was reduced below that seen in the absence of transferrin.	Iron	143-147	transferrin	Mus musculus	29-40
1731957-3	1992	Increasing the saturation of transferrin with iron caused an increased rate of proliferation up to about 100% saturation but when the level of iron present exceeded the binding capacity of the protein, proliferation decreased and at high levels of iron it was reduced below that seen in the absence of transferrin.	Iron	143-147	transferrin	Mus musculus	302-313
1731957-4	1992	Comparison of the degree of iron uptake from transferrin and from iron chelators showed that the hydrophilic chelator ferric nitrilotriacetate (FeNTA) donated larger amounts of iron to cells than did transferrin or the lipophilic chelator ferric-pyridoxal isonicotinoyl hydrazone (FePIH), but did not promote proliferation, and when present in high amounts caused inhibition.	Iron	28-32	transferrin	Mus musculus	45-56
1731957-6	1992	In cells cultured with FeNTA, iron was found predominantly in an insoluble form while in the cells cultured with Fe-transferrin or FePIH the largest proportion of iron was found in the non-ferritin high molecular weight fraction, which probably represents iron in enzymes and other metabolically-important proteins.	Iron	163-167	transferrin	Mus musculus	116-127
1730148-5	1992	Catalytic concentrations of FMN greatly facilitated the NADH-induced reductive release of ferritin-bound iron.	Iron	105-109	formin 1	Mus musculus	28-31
1809169-8	1991	One teacher had spent a season in the merchant marine aboard an iron ore-hauling ship and 2 had worked in the residential construction industry.	Iron	64-68	inositol polyphosphate-5-phosphatase D	Homo sapiens	81-91
1748657-1	1991	Complementation of insertion mutants showed that the polypeptides FatD, FatC, FatB, and FatA are essential for the iron-transport process encoded by pJM1.	Iron	115-119	ferric anguibactin transport protein	Vibrio anguillarum 775	78-82
1961724-2	1991	In the presence of ascorbate and H2O2, an iron chelate attached to Cys-212 of the enzyme human carbonic anhydrase I quickly cleaved the protein between residues Leu-189 and Asp-190 to produce two discrete fragments.	Iron	42-46	carbonic anhydrase 1	Homo sapiens	95-115
1711099-1	1991	Both the iron mobilization protein transferrin and iron itself are found predominantly in oligodendrocytes in the brain and consequently have been hypothesized to have a role in myelination.	Iron	9-13	transferrin	Mus musculus	35-46
1945070-0	1991	Iron modulation of the transferrin gene.	Iron	0-4	transferrin	Mus musculus	23-34
1945070-2	1991	Iron injected into this mouse model decreases liver expression of the reporter enzyme in a manner analogous to its effect on plasma transferrin levels.	Iron	0-4	transferrin	Mus musculus	132-143
2043666-8	1991	Iron released to serum was found to be bound to transferrin.	Iron	0-4	transferrin	Mus musculus	48-59
2043666-10	1991	Reconstituting serum by adding back the dialysate restores release to levels seen in fresh serum, suggesting that low molecular weight serum components, notably bicarbonate, mediate iron transfer from the basolateral membrane to serum transferrin.	Iron	182-186	transferrin	Mus musculus	235-246
1826464-0	1991	Role of iron in T cell activation: TH1 clones differ from TH2 clones in their sensitivity to inhibition of DNA synthesis caused by IgG Mabs against the transferrin receptor and the iron chelator deferoxamine.	Iron	8-12	negative elongation factor complex member C/D	Homo sapiens	35-38
1826464-0	1991	Role of iron in T cell activation: TH1 clones differ from TH2 clones in their sensitivity to inhibition of DNA synthesis caused by IgG Mabs against the transferrin receptor and the iron chelator deferoxamine.	Iron	181-185	negative elongation factor complex member C/D	Homo sapiens	35-38
1760751-0	1991	Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic haemochromatosis patients.	Iron	81-85	CD8a molecule	Homo sapiens	64-67
1760751-5	1991	Follow-up of iron reentry into the transferrin pool at the end of the intensive phlebotomy treatment indicates that the relative proportion of circulating CD4/CD8 cells is critically related to the regulation of iron absorption.	Iron	212-216	CD8a molecule	Homo sapiens	159-162
1937132-1	1991	The essential mediatory role of copper or iron in the manifestation of paraquat toxicity has been demonstrated (Kohen and Chevion (1985) Free Rad.	Iron	42-46	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	142-145
2164931-0	1990	The initial characterization of the iron environment in lipoxygenase by Mossbauer spectroscopy.	Iron	36-40	linoleate 9S-lipoxygenase-4	Glycine max	56-68
2164931-1	1990	The incorporation of 57Fe into two lipoxygenase isoenzymes from soybeans has been achieved making possible the first observations of the iron environment in these proteins using Mossbauer spectroscopy.	Iron	137-141	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2164931-5	1990	Based on the sign of the electric field gradient, the most likely ligand sphere for the iron in native lipoxygenase consists of oxygen and nitrogen ligands in a roughly octahedral field of symmetry.	Iron	88-92	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2164931-9	1990	The Mossbauer spectra (4.2-250 K) for samples of both isoenzymes after oxidation of the iron in native enzyme by the product of lipoxygenase catalysis were extremely broad (20 mm/s) with no obvious narrow resonance lines.	Iron	88-92	linoleate 9S-lipoxygenase-4	Glycine max	128-140
2164931-11	1990	A small molecule containing an iron site sharing many of these Mossbauer and electron paramagnetic resonance properties with lipoxygenase was identified: Fe(II)/(III).diethylenetriaminepentaacetic acid.	Iron	31-35	linoleate 9S-lipoxygenase-4	Glycine max	125-137
2189739-1	1990	Monoclonal antibodies (mAbs) directed against the transferrin receptor are known to inhibit proliferation of cells due to iron deprivation.	Iron	122-126	transferrin	Mus musculus	50-61
2189739-11	1990	Furthermore, we found that enhanced iron uptake by mature M phi is not necessarily accompanied by a higher cell surface expression of transferrin receptors, thus suggesting an increased recycling of transferrin receptors in mature M phi.	Iron	36-40	transferrin	Mus musculus	199-210
2366752-3	1990	After harvesting the cells, they were lysed and the transferrin iron was released with 40% trichloroacetic acid.	Iron	64-68	transferrin	Mus musculus	52-63
2341915-3	1990	Ingestion of supplemental iron slightly decreased heart MnSOD activity and tibia and kidney manganese concentrations but had no effect on hematocrits or on plasma and HDL cholesterol levels.	Iron	26-30	superoxide dismutase 2	Rattus norvegicus	56-61
2338077-2	1990	The purple acid phosphatases and uteroferrin belong to a diverse multifunctional class of binuclear iron-containing proteins that includes haemerythrin and ribonucleotide reductase.	Iron	100-104	acid phosphatase 5, tartrate resistant	Sus scrofa	33-44
2338077-3	1990	In the pig, uteroferrin has been implicated in the delivery of iron to the foetus, but the role of the related human type 5 acid phosphatase that is principally found in resident tissue macrophages is not yet clear.	Iron	63-67	acid phosphatase 5, tartrate resistant	Sus scrofa	12-23
2154337-5	1990	In fact, lipid peroxidation initiated by a ferrous-oxygen complex (as in iron/NADPH-dependent peroxidation) was inhibited by AD 5 in a range of concentration of 2-4 mM.	Iron	73-77	2,4-dienoyl-CoA reductase 1	Homo sapiens	78-83
2154337-6	1990	On the contrary, iron/NADPH-independent lipid peroxidation, where alkoxy radicals (RO.)	Iron	17-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	22-27
33942901-2	2021	Consequently, hepcidin expression is reduced resulting in increased iron absorption and primary iron overload.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	14-22
33942901-2	2021	Consequently, hepcidin expression is reduced resulting in increased iron absorption and primary iron overload.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	14-22
33942901-4	2021	Considering the central role of the TMPRSS6/HJV/hepcidin axis in iron homeostasis, the inhibition of TMPRSS6 expression represents a promising therapeutic strategy to increase hepcidin production and ameliorate anaemia and iron overload in beta-thalassaemia.	Iron	65-69	hemojuvelin BMP co-receptor	Mus musculus	44-47
33761745-4	2021	In addition, iron species were in situ atomically dispersed on the as-formed CeO2-Al2O3 hollow spheres via this strategy, which demonstrated promising potential in transferring syn-gas to valuable gasoline products.	Iron	13-17	synemin	Homo sapiens	177-180
33232517-3	2021	Family with sequence similarity 96 member A (FAM96A) is an evolutionarily conserved protein with high expression in the immune system and is related to cytosolic iron-assembly and tumour suppression; however, research has been rarely conducted on its immune functions.	Iron	162-166	cytosolic iron-sulfur assembly component 2A	Mus musculus	45-51
32574618-4	2020	Both modalities of iron therapy effectively improved anemia in the mice with CKD, and lowered bone Fgf23 expression.	Iron	19-23	fibroblast growth factor 23	Mus musculus	99-104
33033759-2	2020	Previously, we found that iron-depletion downregulated the expression of proteins, arginine methyltransferase-1 and 3 (PRMT1 and PRMT3), by an iron-specific chelator, deferoxamine (DFO), in rat liver FAO cell line using DNA microarray analysis (unpublished data).	Iron	26-30	protein arginine methyltransferase 3	Rattus norvegicus	129-134
33033759-2	2020	Previously, we found that iron-depletion downregulated the expression of proteins, arginine methyltransferase-1 and 3 (PRMT1 and PRMT3), by an iron-specific chelator, deferoxamine (DFO), in rat liver FAO cell line using DNA microarray analysis (unpublished data).	Iron	143-147	protein arginine methyltransferase 3	Rattus norvegicus	129-134
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	167-171	transferrin receptor 2	Mus musculus	91-113
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	167-171	transferrin receptor 2	Mus musculus	115-119
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	167-171	hepcidin antimicrobial peptide	Mus musculus	241-249
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	217-221	homeostatic iron regulator	Mus musculus	83-86
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	217-221	transferrin receptor 2	Mus musculus	91-113
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	217-221	transferrin receptor 2	Mus musculus	115-119
25403101-3	2015	The proteins transmembrane protease, serine 6 (TMPRSS6; also termed matriptase-2), HFE and transferrin receptor 2 (TFR2) play important and opposing roles in systemic iron homeostasis, by regulating expression of the iron regulatory hormone hepcidin.	Iron	217-221	hepcidin antimicrobial peptide	Mus musculus	241-249
27366792-5	2014	This mechanism involves production and release of neutrophil gelatinase-associated lipocalin by alpha-intercalated cells to chelate the siderophore containing host iron to achieve bacteriostasis.	Iron	164-168	lipocalin 2	Homo sapiens	50-92
19624751-4	2009	JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) catalyses removal of H3K9 mono- and dimethylation through iron and alpha-ketoglutarate dependent oxidative reactions.	Iron	135-139	lysine (K)-specific demethylase 3A	Mus musculus	0-6
19624751-4	2009	JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) catalyses removal of H3K9 mono- and dimethylation through iron and alpha-ketoglutarate dependent oxidative reactions.	Iron	135-139	lysine (K)-specific demethylase 3A	Mus musculus	8-53
19624751-4	2009	JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) catalyses removal of H3K9 mono- and dimethylation through iron and alpha-ketoglutarate dependent oxidative reactions.	Iron	135-139	lysine (K)-specific demethylase 3A	Mus musculus	69-75
15626737-9	2005	These data provide valuable insights for novel therapeutic approaches aimed at reinstating the IFN-gamma/STAT1 apoptotic signaling pathway in autoreactive or neoplastic T cells by means of iron chelation.	Iron	189-193	signal transducer and activator of transcription 1	Homo sapiens	105-110
34879569-7	2022	In the proposed mechanism, soluble and surface-bound Fe species are provided by alpha-Fe2O3 to activate H2O2 or PS to radicals, and SeS2 participates in the reactions via Se(IV) reducing Fe(III) to Fe(II) and S atoms being released through protonation to expose more active Se sites.	Iron	53-55	secernin 2	Homo sapiens	132-136
34693556-7	2022	Therefore, this study revealed the comparative dietary enhancing effect of FE- and FA-formulated biscuit on sexual behaviour activity, hormonal levels and the level of eNOS and TNF-alpha genes expressed in hypertensive rats.	Iron	75-77	nitric oxide synthase 3	Rattus norvegicus	168-172
34544203-8	2022	Using genetic and chemical tools, we show zebrafish Hmox1a protects the host against M. marinum infection by reducing infection-induced iron accumulation and ferrostatin-sensitive cell death.	Iron	136-140	heme oxygenase 1a	Danio rerio	52-58
34416697-6	2022	The analysis of various metal transport mutants revealed that mutant affected in calcium (mid1Delta and cch1Delta) and Fe(III) (ftr1Delta) transport, exhibited highly reduced U uptake rates and accumulation, demonstrating the implication of the calcium channel Mid1/Cch1 and the iron permease Ftr1 in U uptake.	Iron	279-283	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	293-297
34619329-3	2022	Toxic metals are taken up and transported across different cellular compartments and plant tissues via transporters for essential or beneficial nutrients, e.g. As by phosphate and silicon transporters, and Cd by manganese (Mn), zinc (Zn) and iron (Fe) transporters.	Iron	242-246	general transcription factor IIE subunit 1	Homo sapiens	248-250
34826895-1	2022	The groundwater within the aquifers of the Ganges River delta exhibits significant spatial variability in concentrations of redox-sensitive solutes (e.g., arsenic (As), iron (Fe), manganese (Mn)).	Iron	169-173	general transcription factor IIE subunit 1	Homo sapiens	175-177
34311304-6	2022	The obtained Fe and N co-doped carbon back (Fe-N/CB) catalyst has very large specific surface area and abundant accessible Fe-Nx moieties.	Iron	13-15	FECB	Homo sapiens	44-51
34311304-6	2022	The obtained Fe and N co-doped carbon back (Fe-N/CB) catalyst has very large specific surface area and abundant accessible Fe-Nx moieties.	Iron	123-125	FECB	Homo sapiens	44-51
34563663-0	2022	Vitamin D decreases pancreatic iron overload in type 2 diabetes through the NF-kappaB-DMT1 pathway.	Iron	31-35	RoBo-1	Rattus norvegicus	86-90
34563663-9	2022	Our study showed that iron overload in pancreas may contribute to T2D pathogenesis and uncovered a potentially protective role for vitamin D on iron deposition of diabetic pancreas through NF-kappaB- DMT1 signaling.	Iron	22-26	RoBo-1	Rattus norvegicus	200-204
34251495-6	2022	Urinary proteins that best discriminated between febrile children with and without UTI were NGAL, a protein that exerts a local bacteriostatic role in the urinary tract through iron chelation; CCL3, a chemokine involved in leukocyte recruitment; and IL-8, a cytokine involved in neutrophil recruitment.	Iron	177-181	lipocalin 2	Homo sapiens	92-96
34878783-5	2021	After doping of W at this boundary, W atoms will selectively substitute the Fe atoms of Fe2O3 that directly bond with three spin-polarized O atoms, thereby resulting in the complete neutralization of the magnetic moments of the spin-polarized O atoms.	Iron	76-78	spindlin 1	Homo sapiens	124-128
34878783-5	2021	After doping of W at this boundary, W atoms will selectively substitute the Fe atoms of Fe2O3 that directly bond with three spin-polarized O atoms, thereby resulting in the complete neutralization of the magnetic moments of the spin-polarized O atoms.	Iron	76-78	spindlin 1	Homo sapiens	228-232
34932791-7	2021	Iron restriction through enhancement of hepcidin activity or inhibition of ferroportin function has been shown to reduce ineffective erythropoiesis in murine models of beta-thalassemia.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	40-48
34914695-0	2021	Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.	Iron	118-122	transferrin	Mus musculus	97-108
34977155-4	2021	Moreover, elevated ferritin levels trigger nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, in which ferritin is degraded and iron is released.	Iron	141-145	nuclear receptor coactivator 4	Homo sapiens	43-73
34977155-4	2021	Moreover, elevated ferritin levels trigger nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, in which ferritin is degraded and iron is released.	Iron	141-145	nuclear receptor coactivator 4	Homo sapiens	75-80
34890402-3	2021	Here we demonstrate that, by using the iron restrictive properties of the antisense oligonucleotides against Tmprss6 mRNA, we can increase hepcidin to achieve effects equivalent to therapeutic phlebotomy.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	139-147
34812447-6	2021	This feature article summarises our recent work on PNN iron complexes, including their conception and design, as well as related reports on iron pincer complexes and iron-catalysed C-H borylation reactions.	Iron	55-59	pinin, desmosome associated protein	Homo sapiens	51-54
34870866-13	2021	FXR negatively regulated iron-regulatory proteins IRP1/2 and prevented hepatic iron accumulation.	Iron	25-29	aconitase 1	Mus musculus	50-56
34861039-7	2022	Our study demonstrates that coordinated mis-splicing of mitochondrial transporters TMEM14C and ABCB7 by mutant SF3B1 sequesters iron in mitochondria, causing ring sideroblast formation.	Iron	128-132	transmembrane protein 14C	Homo sapiens	83-90
34936798-0	2021	Moire Tuning of Spin Excitations: Individual Fe Atoms on MoS_{2}/Au(111).	Iron	45-47	spindlin 1	Homo sapiens	16-20
34936798-3	2021	Even for equivalent adsorption sites with respect to the atomic MoS_{2} lattice, we observe that Fe adatoms exhibit behaviors ranging from pure spin excitations, characteristic of negligible exchange and dominant single-ion anisotropy, to a fully developed Kondo resonance, indicating strong exchange and negligible single-ion anisotropy.	Iron	97-99	spindlin 1	Homo sapiens	144-148
34590183-7	2021	In addition, alcohol drinking increased hypoxic response and decreased hepcidin expression, providing the molecular mechanism of increased iron transporters and Mn uptake upon alcohol consumption.	Iron	139-143	hepcidin antimicrobial peptide	Mus musculus	71-79
34369274-12	2021	Moreover, TFRC activated PTEN induced kinase 1 (PINK1) signaling and induced mitophagy; iron-uptake-induced upregulation of acyl-CoA synthetase long chain family member 4 (ACSL4) was required for mitophagy activation and glutathione peroxidase 4 (GPX4) degradation.	Iron	88-92	PTEN induced kinase 1	Homo sapiens	25-46
34369274-12	2021	Moreover, TFRC activated PTEN induced kinase 1 (PINK1) signaling and induced mitophagy; iron-uptake-induced upregulation of acyl-CoA synthetase long chain family member 4 (ACSL4) was required for mitophagy activation and glutathione peroxidase 4 (GPX4) degradation.	Iron	88-92	PTEN induced kinase 1	Homo sapiens	48-53
34611951-0	2021	Runx3 regulates iron metabolism via modulation of BMP signalling.	Iron	16-20	runt related transcription factor 3	Mus musculus	0-5
34611951-7	2021	RESULT: We observed an iron-overloaded liver with decreased expression of hepcidin in Runx3 KO mice.	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	74-82
34611951-9	2021	Transcriptome analysis on primary hepatocytes isolated from Runx3 cKO mice also revealed that iron-induced increase in BMP6 was mediated by Runx3.	Iron	94-98	runt related transcription factor 3	Mus musculus	60-65
34611951-9	2021	Transcriptome analysis on primary hepatocytes isolated from Runx3 cKO mice also revealed that iron-induced increase in BMP6 was mediated by Runx3.	Iron	94-98	runt related transcription factor 3	Mus musculus	140-145
34098241-3	2021	Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	0-8
34098241-4	2021	Hepcidin deficiency leads to iron overload diseases.	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	0-8
34224321-2	2021	Here, we explored whether upregulation of local hepcidin secreted within the brain is the underlying cause of iron accumulation and associated toxicity.	Iron	110-114	hepcidin antimicrobial peptide	Mus musculus	48-56
34873429-8	2021	In CFA-saline rats, NADPH oxidase- (NOX-) 2, NOX-4, and superoxide dismutase levels in the liver were upregulated compared with those in control rats and their levels were further increased in CFA-iron rats.	Iron	197-201	cytochrome b-245 beta chain	Rattus norvegicus	20-43
34873429-8	2021	In CFA-saline rats, NADPH oxidase- (NOX-) 2, NOX-4, and superoxide dismutase levels in the liver were upregulated compared with those in control rats and their levels were further increased in CFA-iron rats.	Iron	197-201	NADPH oxidase 4	Rattus norvegicus	45-50
34873429-13	2021	Both STAT-3 phosphorylation and SMAD1/5 phosphorylation were associated with hepcidin upregulation after IV iron treatment, and this seems to be linked to iron-induced oxidative stress.	Iron	108-112	SMAD family member 1	Rattus norvegicus	32-39
34873429-13	2021	Both STAT-3 phosphorylation and SMAD1/5 phosphorylation were associated with hepcidin upregulation after IV iron treatment, and this seems to be linked to iron-induced oxidative stress.	Iron	155-159	SMAD family member 1	Rattus norvegicus	32-39
34829689-9	2021	Hfe-/- mice on HI showed very high liver iron levels, decreased mitochondrial respiratory capacity and increased ROS production associated with reduced mitochondrial aconitase activity.	Iron	41-45	homeostatic iron regulator	Mus musculus	0-3
34829689-10	2021	Although Hfe-/- resulted in increased mitochondrial iron loading, the concentration of metabolically reactive cytoplasmic iron and mitochondrial density remained unchanged.	Iron	52-56	homeostatic iron regulator	Mus musculus	9-12
34827665-6	2021	GAA could protect H9c2 cells against ferroptotic cell death caused by these ferroptosis inducers by decreasing the production of malondialdehyde and reactive oxygen species, chelating iron content, and downregulating mRNA levels of Ptgs2.	Iron	184-188	alpha glucosidase	Rattus norvegicus	0-3
34757546-7	2022	We studied how metal ions (zinc & iron) affect tPA-induced thrombolysis in vitro and in vivo, and proposed a method to improve the rate of thrombolysis.	Iron	34-38	chromosome 20 open reading frame 181	Homo sapiens	47-50
34673014-8	2021	Inhibition of CBR1 by chrysin increased cellular ROS levels and led to ROS-dependent autophagy, which resulted in the degradation of ferritin heavy polypeptide 1 (FTH1) and an increase in the intracellular free iron level that participates in ferroptosis in PC cells.	Iron	211-215	carbonyl reductase 1	Homo sapiens	14-18
34311475-2	2021	Inflammation or iron overload stimulates hepcidin release, which causes the accumulation of iron in tissues.	Iron	16-20	hepcidin antimicrobial peptide	Mus musculus	41-49
34311475-2	2021	Inflammation or iron overload stimulates hepcidin release, which causes the accumulation of iron in tissues.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	41-49
34311475-4	2021	Inhibition of hepcidin may increase iron in circulation and improve efficient erythropoiesis.	Iron	36-40	hepcidin antimicrobial peptide	Mus musculus	14-22
34582890-2	2021	The essential step of insertion of iron into the porphyrin macrocycle is mediated by the enzyme ferrochelatase.	Iron	35-39	ferrochelatase	Homo sapiens	96-110
34678314-10	2021	Finally, evaluation of Y113F mutant Pgrmc1, which lacks the axial heme iron-coordinating hydroxyl group, revealed that proper iron coordination is not required for heme binding, but is required for binding to ferrochelatase, the final enzyme in heme biosynthesis.	Iron	71-75	progesterone receptor membrane component 1	Mus musculus	36-42
34678314-10	2021	Finally, evaluation of Y113F mutant Pgrmc1, which lacks the axial heme iron-coordinating hydroxyl group, revealed that proper iron coordination is not required for heme binding, but is required for binding to ferrochelatase, the final enzyme in heme biosynthesis.	Iron	126-130	progesterone receptor membrane component 1	Mus musculus	36-42
34678314-10	2021	Finally, evaluation of Y113F mutant Pgrmc1, which lacks the axial heme iron-coordinating hydroxyl group, revealed that proper iron coordination is not required for heme binding, but is required for binding to ferrochelatase, the final enzyme in heme biosynthesis.	Iron	126-130	ferrochelatase	Mus musculus	209-223
34600336-0	2021	HDAC inhibition induces EMT and alterations in cellular iron homeostasis to augment ferroptosis sensitivity in SW13 cells.	Iron	56-60	histone deacetylase 9	Homo sapiens	0-4
34600336-5	2021	Increased iron accumulation following HDAC inhibitor mediated EMT is associated with decreased expression of the iron export protein ferroportin, enhanced ROS production, and reduced expression of antioxidant response genes.	Iron	10-14	histone deacetylase 9	Homo sapiens	38-42
34600336-5	2021	Increased iron accumulation following HDAC inhibitor mediated EMT is associated with decreased expression of the iron export protein ferroportin, enhanced ROS production, and reduced expression of antioxidant response genes.	Iron	113-117	histone deacetylase 9	Homo sapiens	38-42
34600336-9	2021	As several HDAC inhibitors are already in use clinically for the treatment of certain cancer types, the findings from these studies have immediate implications for improving iron-targeted chemotherapeutic strategies.	Iron	174-178	histone deacetylase 9	Homo sapiens	11-15
34718778-2	2022	"Plastid-type" NFU1, NFU2 and NFU3 in Arabidopsis (Arabidopsis thaliana) play a role in iron-sulfur (Fe-S) cluster assembly in this organelle, whereas the type-II NFU4 and NFU5 proteins have not been subjected to mutant studies in any plant species to determine their biological role.	Iron	101-105	NIFU-like protein 2	Arabidopsis thaliana	21-25
34718778-2	2022	"Plastid-type" NFU1, NFU2 and NFU3 in Arabidopsis (Arabidopsis thaliana) play a role in iron-sulfur (Fe-S) cluster assembly in this organelle, whereas the type-II NFU4 and NFU5 proteins have not been subjected to mutant studies in any plant species to determine their biological role.	Iron	101-105	NFU domain protein 3	Arabidopsis thaliana	30-34
34265052-9	2021	Cellular iron-loading caused a marked increase in CD63 expression and the secretion from cells of CD63 positive (i.e., CD63(+)) EVs, which were shown to contain ferritin-H (FtH) and -L (FtL).	Iron	9-13	ferritin light chain	Homo sapiens	186-189
34265052-10	2021	Our results demonstrate that under iron-loading, intracellular ferritin is transferred via nuclear receptor coactivator 4 (NCOA4) to CD63(+) EVs that are then secreted.	Iron	35-39	nuclear receptor coactivator 4	Homo sapiens	91-121
34265052-10	2021	Our results demonstrate that under iron-loading, intracellular ferritin is transferred via nuclear receptor coactivator 4 (NCOA4) to CD63(+) EVs that are then secreted.	Iron	35-39	nuclear receptor coactivator 4	Homo sapiens	123-128
34733841-5	2021	Furthermore, mRNAs encoding ubiquitin ligase FBXL5, and mitochondrial iron importers SLC25A28 and SLC25A37, were identified as substrates of ALKBH5.	Iron	70-74	solute carrier family 25 member 28	Homo sapiens	85-93
34733841-5	2021	Furthermore, mRNAs encoding ubiquitin ligase FBXL5, and mitochondrial iron importers SLC25A28 and SLC25A37, were identified as substrates of ALKBH5.	Iron	70-74	solute carrier family 25 member 37	Homo sapiens	98-106
34606717-4	2021	HCP3 reacts readily with (dppe)Fe(Cp*)Cl (dppe = 1,2-bis(diphenylphosphino)ethane, Cp*= eta5-C5Me5) in the presence of Na(BPh4) to form a purple cationic iron complex of triphosphatetrahedrane (50% yield), which was structurally characterized in a single-crystal X-ray diffraction experiment.	Iron	154-158	CYCS pseudogene 53	Homo sapiens	0-4
34644351-2	2021	Previous studies in thalassemic mice showed the positive effects of the iron uptake suppressor, hepcidin, on calcium transport.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	96-104
34644351-4	2021	Therefore, this study aimed to investigate the effects of hepcidin on iron and calcium uptake ability under physiological, iron uptake stimulation and calcium uptake suppression.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	58-66
34546267-0	2021	Controllable synthesis of Ni3S2@MOOH/NF (M = Fe, Ni, Cu, Mn and Co) hybrid structure for the efficient hydrogen evolution reaction.	Iron	45-47	neurofascin	Homo sapiens	37-39
34611778-8	2022	GDF-15 did not identify subgroups of patients who might benefit from correction of anemia but was associated with several indices of anemia and iron status in the HF patients.	Iron	144-148	growth differentiation factor 15	Homo sapiens	0-6
34116221-5	2021	INO is highly expressed during early seed development, and that decreased expression of INO increases the expression of NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1 (NRAMP1), a gene encoding a transporter contributing to Fe loading into the seed.	Iron	227-229	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	120-170
34116221-5	2021	INO is highly expressed during early seed development, and that decreased expression of INO increases the expression of NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1 (NRAMP1), a gene encoding a transporter contributing to Fe loading into the seed.	Iron	227-229	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	172-178
34116221-6	2021	The relatively high embryonic Fe accumulation conferred by decreased expression of INO is rescued by the nramp1 loss-of-function mutation.	Iron	30-32	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	105-111
34116221-8	2021	Moreover, we show that excessive Fe loading into developing seeds in ino mutants produces more oxidative damage, leading to increased cell death and seed abortion, a phenotype that can be rescued by nramp1 mutation.	Iron	33-35	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	199-205
34343368-2	2021	An altered MT2 cannot appropriately suppress hepatic BMP6/SMAD signaling in case of low iron, hence hepcidin excess blocks dietary iron absorption, leading to a form of anemia resistant to oral iron supplementation.	Iron	131-135	hepcidin antimicrobial peptide	Mus musculus	100-108
34343368-2	2021	An altered MT2 cannot appropriately suppress hepatic BMP6/SMAD signaling in case of low iron, hence hepcidin excess blocks dietary iron absorption, leading to a form of anemia resistant to oral iron supplementation.	Iron	194-198	hepcidin antimicrobial peptide	Mus musculus	100-108
34468208-2	2021	LCN2 mediates the innate immune response to pathogens by sequestering iron, thereby inhibiting pathogen growth.	Iron	70-74	lipocalin 2	Homo sapiens	0-4
34146401-1	2021	Lipocalin 2 is a siderophore binding protein that regulates iron homeostasis.	Iron	60-64	lipocalin 2	Homo sapiens	0-11
34146401-4	2021	Lipocalin 2 inhibits ferroptosis by decreasing intracellular iron levels and stimulating the expression of glutathione peroxidase4 and a component of the cysteine glutamate antiporter, xCT.	Iron	61-65	lipocalin 2	Homo sapiens	0-11
34461091-7	2021	Deletion of Aim32 or mutation of conserved cysteine residues that coordinate the Fe-S center in Aim32 resulted in an increased accumulation of proteins with aberrant disulfide linkages.	Iron	81-83	Aim32p	Saccharomyces cerevisiae S288C	96-101
34480373-0	2021	Striking While the Iron is Hot: The Role of Prosaposin (PSAP) in Parkinson"s Disease.	Iron	19-23	prosaposin	Homo sapiens	44-54
34494368-2	2021	Herein, a facile yet robust strategy is reported to rationally design single iron active centers synergized with local S atoms in metal-organic frameworks derived from hierarchically porous carbon nanorods (Fe/N,S-HC).	Iron	77-81	general transcription factor IIE subunit 1	Homo sapiens	207-209
34587896-1	2021	BACKGROUND: Cisd1 and Cisd2 proteins share very similar structures with an N-terminal membrane-anchoring domain and a C-terminal cytosolic domain containing an iron-cluster binding domain and ending with a C-terminal KKxx sequence.	Iron	160-164	CDGSH iron sulfur domain 2	Homo sapiens	22-27
34639491-11	2021	High correlation coefficients (r >= 0.8) were found for the elements Mg, Ca, Fe, Al, Cd, Pb, and Zn in the PM1 fraction, Cd, Pb, and Zn in PM2.5, and Ba, Sb, Fe, Cu, Cr, Mg, Al, and Ca in PM2.5-10.	Iron	77-79	transmembrane protein 11	Homo sapiens	107-110
34548401-2	2021	BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response.	Iron	182-184	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	142-149
34548401-10	2021	Moreover, the transcription of both BTS and IMA3 is activated directly by bHLH105 and bHLH115 under Fe-deficient conditions.	Iron	100-102	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	86-93
34548401-11	2021	Our findings provide a conceptual framework for understanding the regulation of Fe homeostasis: IMA peptides protect bHLH105/bHLH115 from degradation by sequestering BTS, thereby activating the Fe deficiency response.	Iron	80-82	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	125-132
34632222-3	2021	The concise physical/chemical picture, the critical spin polarizations, and orbital hybridizations in the Li-O and Fe-O bonds are clearly examined through geometric optimization, quasi-particle energy spectra, spin-polarized density of states, spatial charge densities, spin-density distributions, and strong optical responses.	Iron	115-117	spindlin 1	Homo sapiens	210-214
34632222-3	2021	The concise physical/chemical picture, the critical spin polarizations, and orbital hybridizations in the Li-O and Fe-O bonds are clearly examined through geometric optimization, quasi-particle energy spectra, spin-polarized density of states, spatial charge densities, spin-density distributions, and strong optical responses.	Iron	115-117	spindlin 1	Homo sapiens	270-274
34630348-3	2021	The iron-bound form of these glycoproteins is initially captured by the surface lipoproteins Tf or Lf binding protein B (TbpB or LbpB) and delivered to the integral outer membrane TonB-dependent transport (TBDT) proteins, Tf binding protein A (TbpA) or Lf binding protein A (LbpA).	Iron	4-8	transthyretin	Homo sapiens	222-242
34630348-3	2021	The iron-bound form of these glycoproteins is initially captured by the surface lipoproteins Tf or Lf binding protein B (TbpB or LbpB) and delivered to the integral outer membrane TonB-dependent transport (TBDT) proteins, Tf binding protein A (TbpA) or Lf binding protein A (LbpA).	Iron	4-8	transthyretin	Homo sapiens	244-248
34538261-2	2021	For the first time, the hypothesis that iron overload in megaloblastic anemia may be related to ineffective erythropoiesis is explored by describing the kinetics of hepcidin, erythroferrone, and growth differentiation factor-15 levels in a patient diagnosed with megaloblastic anemia associated with iron overload.	Iron	40-44	growth differentiation factor 15	Homo sapiens	195-227
34538261-2	2021	For the first time, the hypothesis that iron overload in megaloblastic anemia may be related to ineffective erythropoiesis is explored by describing the kinetics of hepcidin, erythroferrone, and growth differentiation factor-15 levels in a patient diagnosed with megaloblastic anemia associated with iron overload.	Iron	300-304	growth differentiation factor 15	Homo sapiens	195-227
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	124-128	interleukin 10	Homo sapiens	43-48
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	124-128	interleukin 10 receptor subunit alpha	Homo sapiens	49-55
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	168-172	interleukin 10	Homo sapiens	43-48
34536483-6	2022	Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration.	Iron	168-172	interleukin 10 receptor subunit alpha	Homo sapiens	49-55
34488769-10	2021	In particular, the mRNA expression of key iron- sulphur proteins POLD1 and PRIM2 was significantly overexpressed and correlated with poor prognosis in LIHC patients.	Iron	42-46	DNA primase subunit 2	Homo sapiens	75-80
34346124-7	2021	Moreover, overexpression of nuclear receptor coactivator 4 (NCOA4) weakened the effect of curcumol on ferritinophagy-mediated iron overload and cellular senescence.	Iron	126-130	nuclear receptor coactivator 4	Homo sapiens	28-58
34346124-7	2021	Moreover, overexpression of nuclear receptor coactivator 4 (NCOA4) weakened the effect of curcumol on ferritinophagy-mediated iron overload and cellular senescence.	Iron	126-130	nuclear receptor coactivator 4	Homo sapiens	60-65
34488018-7	2021	Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth.	Iron	59-63	transferrin	Mus musculus	41-52
34488018-7	2021	Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth.	Iron	169-173	transferrin	Mus musculus	10-21
34488018-7	2021	Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth.	Iron	169-173	transferrin	Mus musculus	41-52
34271453-1	2021	Storage containers are usually used to provide a constant water head in decentralized, community groundwater treatment systems for the removal of iron (Fe) and arsenic (As).	Iron	146-150	general transcription factor IIE subunit 1	Homo sapiens	152-154
34749868-10	2021	Stratified analysis suggested that serum iron was a good predictor of patients with oral cancer aged 60 years(HR=0.62, 95%CI 0.39-0.99), male(HR=0.66, 95%CI 0.44-0.98), with TNM stage I-II(HR=0.42, 95%CI 0.20-0.88) and squamous cell of pathological type(HR=0.69, 95%CI 0.49-0.97).	Iron	41-45	teneurin transmembrane protein 1	Homo sapiens	174-177
34324612-4	2021	Magnetic data revealed that the Fe(ii) complex 1 shows complete SCO with the transition temperature T1/2 = 141 K, which is preserved also in the mixed Fe/Co system 3 (T1/2 = 128 K).	Iron	151-153	general transcription factor IIE subunit 1	Homo sapiens	32-38
34502184-0	2021	Transcription Factor WRKY33 Mediates the Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Arabidopsis Roots.	Iron	116-120	WRKY DNA-binding protein 33	Arabidopsis thaliana	21-27
34417961-11	2021	TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 x 10-6).	Iron	80-82	Myb like, SWIRM and MPN domains 1	Homo sapiens	8-13
34417961-11	2021	TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 x 10-6).	Iron	80-82	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	26-31
34417961-11	2021	TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 x 10-6).	Iron	80-82	adenylate cyclase 8	Homo sapiens	32-37
34443567-7	2021	PRBF would be a powerful supplementary and therapeutic antioxidant product that is understood to be more potent than NAC in ameliorating the effects of iron-induced oxidative stress.	Iron	152-156	NLR family, pyrin domain containing 1A	Mus musculus	117-120
34436298-7	2021	These genes were previously associated with ferroptosis, a programmed cell death triggered by iron-dependent lipid peroxidation, confirmed at the protein level by the down-regulation of GPX4, a key regulator of ferroptosis, and the up-regulation of NCOA4, involved in iron homeostasis.	Iron	94-98	nuclear receptor coactivator 4	Homo sapiens	249-254
34436298-7	2021	These genes were previously associated with ferroptosis, a programmed cell death triggered by iron-dependent lipid peroxidation, confirmed at the protein level by the down-regulation of GPX4, a key regulator of ferroptosis, and the up-regulation of NCOA4, involved in iron homeostasis.	Iron	268-272	nuclear receptor coactivator 4	Homo sapiens	249-254
34445419-6	2021	Exercise reduced levels of cortical hepcidin, a key regulator of iron homeostasis, coupled with interleukin-6 (IL-6) decrease in cortex and plasma.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	36-44
34880854-4	2021	We identified iron-interacting proteins in CD4+ and CD8+ T-cell proteomes that were differentially expressed during activation, suggesting that pathways enriched with such proteins, including histone demethylation, may be impaired by iron deficiency.	Iron	14-18	CD4 antigen	Mus musculus	43-46
34880854-5	2021	Consistent with this, iron-starved Th17 cells showed elevated expression of the repressive histone mark H3K27me3 and displayed reduced RORgammat and IL-17a, highlighting a previously unappreciated role for iron in T-cell differentiation.	Iron	22-26	interleukin 17A	Mus musculus	149-155
34434202-6	2021	AtMTM1 and AtMTM2 are involved in Mn and Fe homeostasis, root length, and flowering time.	Iron	41-43	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	11-17
34089433-0	2021	Increased iron content in the heart of the Fmr1 knockout mouse.	Iron	10-14	fragile X messenger ribonucleoprotein 1	Mus musculus	43-47
34089433-4	2021	Altogether, seven minerals-Cu, Fe, K, Mg, Mn, Na, and P-were above the detection limit with the analysis revealing increased iron content in the heart of Fmr1 KO mice.	Iron	31-33	fragile X messenger ribonucleoprotein 1	Mus musculus	154-158
34089433-4	2021	Altogether, seven minerals-Cu, Fe, K, Mg, Mn, Na, and P-were above the detection limit with the analysis revealing increased iron content in the heart of Fmr1 KO mice.	Iron	125-129	fragile X messenger ribonucleoprotein 1	Mus musculus	154-158
34588115-3	2021	While the physiological importance of iron (Fe) in electron transport and N-fixation is well known, relatively little is known about its impacts on the growth of freshwater cyanobacteria.	Iron	38-42	general transcription factor IIE subunit 1	Homo sapiens	44-46
34198093-3	2021	Supplemental Fe decreased (P < 0.03) the divalent metal transporter 1 (DMT1) mRNA levels in the duodenum and jejunum, and ferroportin 1 (FPN1) mRNA levels in the duodenum on d 21, but no differences (P > 0.20) were detected among different Fe sources.	Iron	13-15	ferrous ion membrane transport protein DMT1	Glycine max	41-69
34198093-3	2021	Supplemental Fe decreased (P < 0.03) the divalent metal transporter 1 (DMT1) mRNA levels in the duodenum and jejunum, and ferroportin 1 (FPN1) mRNA levels in the duodenum on d 21, but no differences (P > 0.20) were detected among different Fe sources.	Iron	13-15	ferrous ion membrane transport protein DMT1	Glycine max	71-75
34198093-4	2021	Regardless of Fe source, the mRNA levels of DMT1 and FPN1 were higher (P < 0.02) in the duodenum than in the jejunum and ileum, and in the jejunum than in the ileum (P < 0.05).	Iron	14-16	ferrous ion membrane transport protein DMT1	Glycine max	44-48
34359704-10	2021	Optical microscopy of tissue sections confirmed that F4/80+CD11b+ TAMs infiltrated the tumors and accumulated SPION iron.	Iron	116-120	integrin subunit alpha M	Homo sapiens	59-64
34440294-0	2021	Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron.	Iron	99-103	Ccc1p	Saccharomyces cerevisiae S288C	32-36
34440294-4	2021	Yeast cells use the vacuolar Ccc1 transporter to detoxify and store excess iron in the vacuoles.	Iron	75-79	Ccc1p	Saccharomyces cerevisiae S288C	29-33
34440294-5	2021	Here, we modulate CCC1 expression and properties to increase iron extraction from the environment.	Iron	61-65	Ccc1p	Saccharomyces cerevisiae S288C	18-22
34169954-0	2021	Spin and valence isomerism in cyanide-bridged {FeMII} (M = Fe and Co) clusters.	Iron	59-61	spindlin 1	Homo sapiens	0-4
34354946-1	2021	Objectives: A novel ultrasound contrast agent (UCA) VEGFR2-targeting iron-doped silica (SiO2) hollow nanoparticles (VEGFR2-PEG-HSNs-Fe NPs) was prepared and applied in microwave ablation for breast cancer to investigate its value in the evaluation of effectiveness after tumor ablation.	Iron	69-73	kinase insert domain receptor	Homo sapiens	52-58
34354946-1	2021	Objectives: A novel ultrasound contrast agent (UCA) VEGFR2-targeting iron-doped silica (SiO2) hollow nanoparticles (VEGFR2-PEG-HSNs-Fe NPs) was prepared and applied in microwave ablation for breast cancer to investigate its value in the evaluation of effectiveness after tumor ablation.	Iron	69-73	kinase insert domain receptor	Homo sapiens	116-122
34335526-1	2021	Previous work demonstrated that microbial Fe(III)-reduction contributes to void formation, and potentially cave formation within Fe(III)-rich rocks, such as banded iron formation (BIF), iron ore and canga (a surficial duricrust), based on field observations and static batch cultures.	Iron	164-168	general transcription factor IIE subunit 1	Homo sapiens	42-49
34335526-1	2021	Previous work demonstrated that microbial Fe(III)-reduction contributes to void formation, and potentially cave formation within Fe(III)-rich rocks, such as banded iron formation (BIF), iron ore and canga (a surficial duricrust), based on field observations and static batch cultures.	Iron	164-168	general transcription factor IIE subunit 1	Homo sapiens	129-136
34335526-1	2021	Previous work demonstrated that microbial Fe(III)-reduction contributes to void formation, and potentially cave formation within Fe(III)-rich rocks, such as banded iron formation (BIF), iron ore and canga (a surficial duricrust), based on field observations and static batch cultures.	Iron	186-190	general transcription factor IIE subunit 1	Homo sapiens	42-49
34335526-1	2021	Previous work demonstrated that microbial Fe(III)-reduction contributes to void formation, and potentially cave formation within Fe(III)-rich rocks, such as banded iron formation (BIF), iron ore and canga (a surficial duricrust), based on field observations and static batch cultures.	Iron	186-190	general transcription factor IIE subunit 1	Homo sapiens	129-136
34335526-3	2021	Given that static batch cultures are unlikely to reflect the dynamics of groundwater flow conditions in situ, we carried out comparative batch and column experiments to extend our understanding of the mass transport of iron and other solutes under flow conditions, and its effect on community structure dynamics and Fe(III)-reduction.	Iron	219-223	general transcription factor IIE subunit 1	Homo sapiens	316-323
34335526-9	2021	Our results also suggest that reductive weathering of Fe(III)-rich rocks such as canga, BIF, and iron ores may be more substantial than previously understood.	Iron	97-101	general transcription factor IIE subunit 1	Homo sapiens	54-61
34236052-3	2021	Here, we studied the role of the iron storage protein ferritin H (FTH) for the control of infections with the intracellular pathogen Salmonella enterica serovar Typhimurium by macrophages.	Iron	33-37	ferritin heavy polypeptide 1	Mus musculus	66-69
34236052-4	2021	Mice lacking FTH in the myeloid lineage (LysM-Cre+/+Fthfl/fl mice) displayed impaired iron storage capacities in the tissue leukocyte compartment, increased levels of labile iron in macrophages, and an accelerated macrophage-mediated iron turnover.	Iron	86-90	ferritin heavy polypeptide 1	Mus musculus	13-16
34236052-4	2021	Mice lacking FTH in the myeloid lineage (LysM-Cre+/+Fthfl/fl mice) displayed impaired iron storage capacities in the tissue leukocyte compartment, increased levels of labile iron in macrophages, and an accelerated macrophage-mediated iron turnover.	Iron	174-178	ferritin heavy polypeptide 1	Mus musculus	13-16
34236052-4	2021	Mice lacking FTH in the myeloid lineage (LysM-Cre+/+Fthfl/fl mice) displayed impaired iron storage capacities in the tissue leukocyte compartment, increased levels of labile iron in macrophages, and an accelerated macrophage-mediated iron turnover.	Iron	234-238	ferritin heavy polypeptide 1	Mus musculus	13-16
34226519-7	2021	At biochemical level, we further identified that cADPR, the mainly hydrolytic product of CD38, was responsible for inducing the opening of TRPM2 iron channel leading to the influx of intracellular Ca2+ and then led to increasing levels of NRF2 while decreasing expression of KEAP1 in lung cancer cells.	Iron	145-149	transient receptor potential cation channel subfamily M member 2	Homo sapiens	139-144
34127497-0	2021	Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.	Iron	35-39	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	8-12
34127497-6	2021	Loss of SDHB specifically led to increased oxidative stress associated with dysregulated iron and copper homeostasis in the absence of NRF2 activation.	Iron	89-93	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	8-12
34127497-8	2021	These data establish a mechanism linking oxidative stress to iron homeostasis that specifically occurs in Sdhb-deficient cells and may promote metastasis.	Iron	61-65	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	106-110
34193175-4	2021	A 273 amino acid membrane transporter that is a member of the vacuolar iron transporter (VIT) family and an orthologue of the yeast Ca2+-sensitive cross complementer (CCC1) protein plays a major role in cytosolic iron detoxification of Plasmodium species and functions in transport of ferrous iron ions into the endoplasmic reticulum for storage.	Iron	71-75	Ccc1p	Saccharomyces cerevisiae S288C	167-171
34193175-4	2021	A 273 amino acid membrane transporter that is a member of the vacuolar iron transporter (VIT) family and an orthologue of the yeast Ca2+-sensitive cross complementer (CCC1) protein plays a major role in cytosolic iron detoxification of Plasmodium species and functions in transport of ferrous iron ions into the endoplasmic reticulum for storage.	Iron	213-217	Ccc1p	Saccharomyces cerevisiae S288C	167-171
34214670-7	2021	The P450 domains can catalyze heterolytic cleavage of 8- and 10-hydroperoxides with oxidation of the heme thiolate iron for hydroxylation at C-5, C-7, C-9, or C-11 and for epoxidation of the 12Z double bond; thus displaying linoleate diol synthases (LDS) and epoxy alcohol synthase (EAS).	Iron	115-119	RNA polymerase III subunit K	Homo sapiens	159-163
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	97-101	nuclear receptor coactivator 4	Homo sapiens	49-79
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	97-101	nuclear receptor coactivator 4	Homo sapiens	81-86
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	187-191	nuclear receptor coactivator 4	Homo sapiens	49-79
34258295-5	2021	Heat shock protein family B member 1 (HSPB1) and nuclear receptor coactivator 4 (NCOA4) regulate iron homeostasis preventing ferroptosis caused by the high concentration of intracellular iron.	Iron	187-191	nuclear receptor coactivator 4	Homo sapiens	81-86
34207798-8	2021	A trend of shorter overall survival was found in FE-induced MPM patients with SRSF1 overexpression.	Iron	49-51	serine and arginine rich splicing factor 1	Homo sapiens	78-83
34064075-5	2021	Iron is an essential micronutrient for the thyroid gland needed for effective iodine utilization by the iron-dependent enzyme thyroid iodine peroxidase (TPO).	Iron	0-4	thyroid peroxidase	Homo sapiens	126-151
34064075-5	2021	Iron is an essential micronutrient for the thyroid gland needed for effective iodine utilization by the iron-dependent enzyme thyroid iodine peroxidase (TPO).	Iron	0-4	thyroid peroxidase	Homo sapiens	153-156
34064075-5	2021	Iron is an essential micronutrient for the thyroid gland needed for effective iodine utilization by the iron-dependent enzyme thyroid iodine peroxidase (TPO).	Iron	104-108	thyroid peroxidase	Homo sapiens	126-151
34064075-5	2021	Iron is an essential micronutrient for the thyroid gland needed for effective iodine utilization by the iron-dependent enzyme thyroid iodine peroxidase (TPO).	Iron	104-108	thyroid peroxidase	Homo sapiens	153-156
34069657-6	2021	The spectroscopic characterization of cysteine mutated variants together with modeling of the Fe-S cluster-bound GRX homodimer from the structure of an apo-GRX2 indicate the existence of an atypical Fe-S cluster environment and ligation mode.	Iron	199-203	uncharacterized protein	Chlamydomonas reinhardtii	156-160
34068342-4	2021	In addition, several steps of the translation process depend on iron-containing enzymes, including particular modifications of translation elongation factors and transfer RNAs (tRNAs), and translation termination by the ATP-binding cassette family member Rli1 (ABCE1 in humans) and the prolyl hydroxylase Tpa1.	Iron	64-68	ATP binding cassette subfamily E member 1	Homo sapiens	255-259
34068342-4	2021	In addition, several steps of the translation process depend on iron-containing enzymes, including particular modifications of translation elongation factors and transfer RNAs (tRNAs), and translation termination by the ATP-binding cassette family member Rli1 (ABCE1 in humans) and the prolyl hydroxylase Tpa1.	Iron	64-68	ATP binding cassette subfamily E member 1	Homo sapiens	261-266
34063252-4	2021	To be administered with different bread formulations, HFD-fed C57BL/6J mice were distributed in different groups: (i) wild type, (ii) displaying inherited disturbances in glucose homeostasis, and (iii) displaying dietary iron-mediated impairment of the innate immune TLR4/TRAM/TRIF pathway.	Iron	221-225	toll-like receptor adaptor molecule 2	Mus musculus	272-276
34063252-4	2021	To be administered with different bread formulations, HFD-fed C57BL/6J mice were distributed in different groups: (i) wild type, (ii) displaying inherited disturbances in glucose homeostasis, and (iii) displaying dietary iron-mediated impairment of the innate immune TLR4/TRAM/TRIF pathway.	Iron	221-225	toll-like receptor adaptor molecule 2	Mus musculus	277-281
35439490-9	2022	In this review, we check out the link between heavy metals like copper (Cu), arsenic (As), cadmium (Cd), iron (Fe), and lithium (Li) in neurodegeneration, and how it impacts the pathological conditions of PD.	Iron	105-109	general transcription factor IIE subunit 1	Homo sapiens	111-113
35595033-6	2022	Ferroptosis induced by ethanol- or acetaldehyde involving nuclear receptor co-activator 4 (NCOA4)-dependent autophagic degradation of ferritin, a protein for storing iron is rescued by silibinin.	Iron	166-170	nuclear receptor coactivator 4	Homo sapiens	58-89
35595033-6	2022	Ferroptosis induced by ethanol- or acetaldehyde involving nuclear receptor co-activator 4 (NCOA4)-dependent autophagic degradation of ferritin, a protein for storing iron is rescued by silibinin.	Iron	166-170	nuclear receptor coactivator 4	Homo sapiens	91-96
35306063-1	2022	Iron (Fe) plays a dual role in atmospheric chemistry: it is involved in chemical and photochemical reactivity and serves as a micronutrient for microorganisms that have recently been shown to produce strong organic ligands.	Iron	0-4	general transcription factor IIE subunit 1	Homo sapiens	6-8
35461839-1	2022	AIMS: Nuclear prelamin A recognition factor-like (NARFL) is involved in cytosolic iron-sulfur (FeS) protein biogenesis and cellular defense against oxidative stress.	Iron	95-98	nuclear prelamin A recognition factor-like	Danio rerio	6-48
35461839-1	2022	AIMS: Nuclear prelamin A recognition factor-like (NARFL) is involved in cytosolic iron-sulfur (FeS) protein biogenesis and cellular defense against oxidative stress.	Iron	95-98	nuclear prelamin A recognition factor-like	Danio rerio	50-55
35285505-0	2022	MIR164b represses iron uptake by regulating the NAC domain transcription factor5-Nuclear Factor Y, Subunit A8 module in Arabidopsis.	Iron	18-22	nuclear factor Y, subunit A8	Arabidopsis thaliana	81-109
35285505-9	2022	Like overexpression of NAC5, overexpression of NFYA8 increases primary root length, lateral root number, ferric reductase activity, and mRNA abundance of IRT1 and FRO2 under Fe-deficient conditions.	Iron	174-176	nuclear factor Y, subunit A8	Arabidopsis thaliana	47-52
35285505-9	2022	Like overexpression of NAC5, overexpression of NFYA8 increases primary root length, lateral root number, ferric reductase activity, and mRNA abundance of IRT1 and FRO2 under Fe-deficient conditions.	Iron	174-176	iron-regulated transporter 1	Arabidopsis thaliana	154-158
35472742-3	2022	The hepatocytes incubated with Fe-Prot ES had lower (P < 0.009) Fe concentration than those incubated with Fe sulfate, Fe-Met W or Fe-Prot M. The SDH mRNA level was lower (P < 0.05) in Fe sulfate and Fe-Prot ES groups than in Fe-Prot M group.	Iron	185-187	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	146-149
35274348-2	2022	Hepcidin, the master regulator of iron, is secreted by the liver in response to interleukin 6 (IL-6) and/or bone morphogenetic protein 6 (BMP6) and can cause microcytosis.	Iron	34-38	interleukin 6	Canis lupus familiaris	80-93
35274348-2	2022	Hepcidin, the master regulator of iron, is secreted by the liver in response to interleukin 6 (IL-6) and/or bone morphogenetic protein 6 (BMP6) and can cause microcytosis.	Iron	34-38	interleukin 6	Canis lupus familiaris	95-99
35422451-1	2022	E3 ligase BRUTUS (BTS), a putative iron sensor, is expressed in both root and shoot tissues in seedlings of Arabidopsis thaliana.	Iron	35-39	zinc finger protein-like protein	Arabidopsis thaliana	18-21
35472311-4	2022	Here, we show that Arabidopsis LOW PHOSPHATE ROOT 1 (LPR1), one key determinant of Fe-dependent Pi sensing in root meristems, encodes a novel ferroxidase of high substrate specificity and affinity (apparent KM ~ 2 muM Fe2+).	Iron	83-85	Cupredoxin superfamily protein	Arabidopsis thaliana	31-51
35472311-4	2022	Here, we show that Arabidopsis LOW PHOSPHATE ROOT 1 (LPR1), one key determinant of Fe-dependent Pi sensing in root meristems, encodes a novel ferroxidase of high substrate specificity and affinity (apparent KM ~ 2 muM Fe2+).	Iron	83-85	Cupredoxin superfamily protein	Arabidopsis thaliana	53-57
35472311-7	2022	Our molecular and kinetic data on LPR1 regulation indicate that Pi-dependent Fe substrate availability determines LPR1 activity and function.	Iron	77-79	Cupredoxin superfamily protein	Arabidopsis thaliana	34-38
35472311-7	2022	Our molecular and kinetic data on LPR1 regulation indicate that Pi-dependent Fe substrate availability determines LPR1 activity and function.	Iron	77-79	Cupredoxin superfamily protein	Arabidopsis thaliana	114-118
35472311-8	2022	Guided by the metabolic lifestyle of extant sister bacterial genera, we propose that Arabidopsis LPR1 monitors subtle concentration differentials of external Fe availability as a Pi-dependent cue to adjust root meristem maintenance via Fe redox signaling and cell wall modification.	Iron	158-160	Cupredoxin superfamily protein	Arabidopsis thaliana	97-101
35472311-8	2022	Guided by the metabolic lifestyle of extant sister bacterial genera, we propose that Arabidopsis LPR1 monitors subtle concentration differentials of external Fe availability as a Pi-dependent cue to adjust root meristem maintenance via Fe redox signaling and cell wall modification.	Iron	236-238	Cupredoxin superfamily protein	Arabidopsis thaliana	97-101
35584228-4	2022	First, a variant that disrupted the primary iron (Fe) uptake transporter gene (IRT1) swept quickly to fixation in a hard selective sweep, increasing Mn but limiting Fe in the leaves.	Iron	50-52	iron-regulated transporter 1	Arabidopsis thaliana	79-83
35584228-4	2022	First, a variant that disrupted the primary iron (Fe) uptake transporter gene (IRT1) swept quickly to fixation in a hard selective sweep, increasing Mn but limiting Fe in the leaves.	Iron	165-167	iron-regulated transporter 1	Arabidopsis thaliana	79-83
35584228-5	2022	Second, multiple independent tandem duplications occurred at NRAMP1 and together rose to near fixation in the island population, compensating the loss of IRT1 by improving Fe homeostasis.	Iron	172-174	natural resistance-associated macrophage protein 1	Arabidopsis thaliana	61-67
35584228-5	2022	Second, multiple independent tandem duplications occurred at NRAMP1 and together rose to near fixation in the island population, compensating the loss of IRT1 by improving Fe homeostasis.	Iron	172-174	iron-regulated transporter 1	Arabidopsis thaliana	154-158
35512338-0	2022	Cooperative C-H Bond Activation by a Low-Spin d6 Iron-Aluminum Complex.	Iron	49-53	spindlin 1	Homo sapiens	41-45
35512338-5	2022	Here, we show that inclusion of an aluminum-based ligand into the coordination sphere of neutral low-spin d6 iron complex leads to unexpected reactivity.	Iron	109-113	spindlin 1	Homo sapiens	101-105
35597283-0	2022	SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39.	Iron	63-67	GTP dependent ribosome recycling factor mitochondrial 2	Homo sapiens	11-15
35635455-5	2022	Under physiological conditions, transferrin-bound iron is the predominant form of iron taken up by the placenta.	Iron	50-54	transferrin	Mus musculus	32-43
35635455-5	2022	Under physiological conditions, transferrin-bound iron is the predominant form of iron taken up by the placenta.	Iron	82-86	transferrin	Mus musculus	32-43
35635455-6	2022	Thus, 58Fe-transferrin was prepared and injected intravenously in pregnant dams to directly assess placental iron transport and bypass maternal intestinal iron absorption as a confounding variable.	Iron	109-113	transferrin	Mus musculus	11-22
35531957-1	2022	Friedreich"s ataxia (FRDA) is an inherited disorder caused by reduced levels of frataxin (FXN), which is required for iron-sulfur cluster biogenesis.	Iron	118-122	frataxin	Mus musculus	80-88
35531957-1	2022	Friedreich"s ataxia (FRDA) is an inherited disorder caused by reduced levels of frataxin (FXN), which is required for iron-sulfur cluster biogenesis.	Iron	118-122	frataxin	Mus musculus	90-93
35196874-11	2022	In controls, there was a positive correlation between CD163 and iron, which was lost after SAH.	Iron	64-68	CD163 molecule	Homo sapiens	54-59
35487763-1	2022	Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes.	Iron	165-169	RoBo-1	Rattus norvegicus	108-112
35487763-6	2022	Our findings imply that the verapamil-induced reduction in NTBI uptake by H9C2 cells is not associated with DMT1 and also indicate that verapamil stimulates rather than inhibits DMT1 expression and DMT1-mediated iron uptake by heart cells.	Iron	212-216	RoBo-1	Rattus norvegicus	198-202
35472080-1	2022	Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	127-135
35472080-1	2022	Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis.	Iron	114-118	hepcidin antimicrobial peptide	Mus musculus	127-135
35472080-2	2022	Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and iron uptake from enterocytes.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	20-28
35472080-2	2022	Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and iron uptake from enterocytes.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	20-28
35472080-2	2022	Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and iron uptake from enterocytes.	Iron	120-124	hepcidin antimicrobial peptide	Mus musculus	20-28
35472080-10	2022	We propose that in macrophages, autophagy restricts ferroportin level and iron export resulting in hepcidin expression with an autocrine-paracrine effect that takes part in the regulation of the ferroportin expression in duodenal enterocytes.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	99-107
35547771-11	2022	Inhibition of SCD1/FADS2 directly downregulated GPX4 and the GSH/GSSG ratio, causing disruption of the cellular/mitochondrial redox balance and subsequently, iron-mediated lipid peroxidation and mitochondrial dysfunction in ascites-derived OvCa cells.	Iron	158-162	stearoyl-Coenzyme A desaturase 1	Mus musculus	14-18
35547771-11	2022	Inhibition of SCD1/FADS2 directly downregulated GPX4 and the GSH/GSSG ratio, causing disruption of the cellular/mitochondrial redox balance and subsequently, iron-mediated lipid peroxidation and mitochondrial dysfunction in ascites-derived OvCa cells.	Iron	158-162	fatty acid desaturase 2	Mus musculus	19-24
35624674-0	2022	PPARdelta Activation Mitigates 6-OHDA-Induced Neuronal Damage by Regulating Intracellular Iron Levels.	Iron	90-94	peroxisome proliferator activated receptor delta	Homo sapiens	0-9
35624674-3	2022	In the present study, we assessed the role of the nuclear receptor peroxisome proliferator-activated receptor delta (PPARdelta) in cellular iron homeostasis.	Iron	140-144	peroxisome proliferator activated receptor delta	Homo sapiens	67-115
35624674-3	2022	In the present study, we assessed the role of the nuclear receptor peroxisome proliferator-activated receptor delta (PPARdelta) in cellular iron homeostasis.	Iron	140-144	peroxisome proliferator activated receptor delta	Homo sapiens	117-126
35624674-6	2022	Further, PPARdelta activation also suppressed iron accumulation, which contributes to 6-OHDA-induced neuronal damage.	Iron	46-50	peroxisome proliferator activated receptor delta	Homo sapiens	9-18
35624674-8	2022	We further elucidated that PPARdelta modulated cellular iron homeostasis by regulating expression of divalent metal transporter 1, ferroportin 1, and ferritin, but not transferrin receptor 1, through iron regulatory protein 1 in 6-OHDA-treated cells.	Iron	56-60	peroxisome proliferator activated receptor delta	Homo sapiens	27-36
35624674-11	2022	Taken together, these findings suggest that PPARdelta attenuates 6-OHDA-induced neurotoxicity by preventing intracellular iron accumulation, thereby suppressing iron overload-associated generation of reactive oxygen species and lipid peroxides, key mediators of ferroptotic cell death.	Iron	122-126	peroxisome proliferator activated receptor delta	Homo sapiens	44-53
35624674-11	2022	Taken together, these findings suggest that PPARdelta attenuates 6-OHDA-induced neurotoxicity by preventing intracellular iron accumulation, thereby suppressing iron overload-associated generation of reactive oxygen species and lipid peroxides, key mediators of ferroptotic cell death.	Iron	161-165	peroxisome proliferator activated receptor delta	Homo sapiens	44-53
35221009-0	2022	Expression of Concern: Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/beta-catenin pathway in colon cancer cells.	Iron	23-27	N-myc downstream regulated 1	Homo sapiens	62-67
35496960-0	2022	Evaluation of Iron Status by Reticulocyte Haemoglobin Content (Chr) in Chronic Kidney Disease Patients on Haemodialysis and Erythropoietin.	Iron	14-18	chromate resistance; sulfate transport	Homo sapiens	63-66
35496960-10	2022	Reticulocyte haemoglobin (CHr) can be used as an early predictor of response to IV iron therapy.	Iron	83-87	chromate resistance; sulfate transport	Homo sapiens	26-29
35292508-3	2022	The aim of this study is to characterize the hepcidin and erythroid regulators (growth differentiation factor 15 (GDF-15) and erythroferrone (ERFE)) by measuring concentrations in plasma in context of COVID-19 disease.We performed a single-center observational study of patients with COVID-19 to evaluate concentrations of main regulatory proteins involved in iron homeostasis, namely: hepcidin, ERFE and GDF-15.	Iron	360-364	growth differentiation factor 15	Homo sapiens	80-112
35346040-9	2022	Furthermore, in mnb1 mutants, the transcription level of the Fe uptake- and translocation-related genes, FIT, IRT1, FRO2, ZIF, FRD3, NAS4, PYE and MYB72, were considerably elevated during Fe-deficiency stress, resulting in enhanced Fe uptake and translocation, thereby increasing Fe accumulation.	Iron	61-63	iron-regulated transporter 1	Arabidopsis thaliana	110-114
35408955-0	2022	Melatonin Regulates Iron Homeostasis by Inducing Hepcidin Expression in Hepatocytes.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	49-57
35408955-2	2022	The hepatic peptide hormone, hepcidin, regulates iron homeostasis by triggering the degradation of ferroportin (FPN), the protein that transfers cellular iron to the blood.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	29-37
35408955-2	2022	The hepatic peptide hormone, hepcidin, regulates iron homeostasis by triggering the degradation of ferroportin (FPN), the protein that transfers cellular iron to the blood.	Iron	154-158	hepcidin antimicrobial peptide	Mus musculus	29-37
35408955-5	2022	Interestingly, hepcidin gene expression was increased during the dark cycle in the liver of mice, whereas serum iron levels decreased following hepcidin expression.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	144-152
35408955-6	2022	In addition, melatonin significantly induced hepcidin gene expression and secretion, as well as the subsequent FPN degradation in hepatocytes, which resulted in cellular iron accumulation.	Iron	170-174	hepcidin antimicrobial peptide	Mus musculus	45-53
35167749-0	2022	Analysis of the Geometric and Electronic Structure of Spin-Coupled Iron-Sulfur Dimers with Broken-Symmetry DFT: Implications for FeMoco.	Iron	67-71	spindlin 1	Homo sapiens	54-58
35167749-3	2022	In this work, we present a geometric benchmarking test set, FeMoD11, of synthetic spin-coupled Fe-Fe and Mo-Fe dimers, with relevance to the molecular and electronic structure of the Mo-nitrogenase FeMo cofactor.	Iron	95-97	spindlin 1	Homo sapiens	82-86
35167749-3	2022	In this work, we present a geometric benchmarking test set, FeMoD11, of synthetic spin-coupled Fe-Fe and Mo-Fe dimers, with relevance to the molecular and electronic structure of the Mo-nitrogenase FeMo cofactor.	Iron	98-100	spindlin 1	Homo sapiens	82-86
35167749-3	2022	In this work, we present a geometric benchmarking test set, FeMoD11, of synthetic spin-coupled Fe-Fe and Mo-Fe dimers, with relevance to the molecular and electronic structure of the Mo-nitrogenase FeMo cofactor.	Iron	108-110	spindlin 1	Homo sapiens	82-86
35272187-7	2022	Exposure to 5 ppm Cd caused iron accumulation, increased levels of malondialdehyde (MDA) and nitro tyrosine (3-NT), and decreased expression of Nrf2, HO-1 and SOD2.	Iron	28-32	cathepsin D	Mus musculus	18-20
35272187-9	2022	These findings indicate that 5 ppm Cd exposure increased testicular ferroptosis, which may be attributed to the reduction of stored iron export.	Iron	132-136	cathepsin D	Mus musculus	35-37
35249107-6	2022	RNA immunoprecipitation experiments revealed that NSUN5 binds to FTH1/FTL, while NSUN5 depletion reduced the levels of 5-methylcytosine in FTH1/FTL RNA and increased intracellular iron concentrations, resulting in the downregulation of glutathione peroxidase 4 (GPX4) and the accumulation of ROS and lipid peroxidation products.	Iron	180-184	NOP2/Sun RNA methyltransferase 5	Homo sapiens	81-86
34997963-4	2022	Taken together, our findings suggest that CISD2 protects cardiomyocytes from overaccumulation of iron, which is common in aging hearts and can contribute to the pathogenesis of heart failure.	Iron	97-101	CDGSH iron sulfur domain 2	Mus musculus	42-47
35064776-4	2022	RESULTS: In the Vit B6 group, a decrease in feed intake (FI), egg production (EP), albumin, Zn, Fe and Mg, and an increase in triglyceride and insulin in HSC were observed, in addition to a decrease in cholesterol and an increase in egg weight (EW) in NC.	Iron	96-98	vitrin	Gallus gallus	16-19
35208143-2	2022	In this work, we compared the biodegradation of pure iron prepared by microwave sintering and laser melting (designated as MSed Fe and LMed Fe, respectively).	Iron	53-57	general transcription factor IIE subunit 1	Homo sapiens	128-130
35208143-2	2022	In this work, we compared the biodegradation of pure iron prepared by microwave sintering and laser melting (designated as MSed Fe and LMed Fe, respectively).	Iron	53-57	general transcription factor IIE subunit 1	Homo sapiens	140-142
35048936-3	2022	Benefiting from the hierarchical structure, the exposure of more active sites and the doping effect of N and Fe, the N-Fe-Ni3S2@NiP2/NF material showed excellent electrocatalytic activity for the OER and UOR.	Iron	109-111	neurofascin	Homo sapiens	133-135
35377584-2	2022	Three cysteine desulfurases, IscS, NifS, and SufS, have been identified in ISC, NIF, and SUF/SUF-like systems for iron-sulfur (Fe-S) cluster biosynthesis, respectively.	Iron	127-131	S100 calcium binding protein A9	Homo sapiens	80-83
35204767-3	2022	In this study, we observed that 6-hydroxydopamine (6-OHDA) induced the expression of divalent metal transporter-1 (DMT1) and iron influx in BV2 microglia cells, which might be associated with the upregulation of iron regulatory protein 1 (IRP1) expression.	Iron	125-129	aconitase 1	Mus musculus	239-243
35252470-1	2022	Friedreich"s ataxia is a rare disorder resulting from deficiency of frataxin, a mitochondrial protein implicated in the synthesis of iron-sulfur clusters.	Iron	133-137	frataxin	Mus musculus	68-76
35252470-6	2022	We demonstrated that toxicity required frataxin"s primary function by using a frataxin construct bearing the N146K mutation, which impairs binding to the iron-sulfur cluster core complex.	Iron	154-158	frataxin	Mus musculus	39-47
35252470-6	2022	We demonstrated that toxicity required frataxin"s primary function by using a frataxin construct bearing the N146K mutation, which impairs binding to the iron-sulfur cluster core complex.	Iron	154-158	frataxin	Mus musculus	78-86
35518804-1	2022	Methemoglobinemia is a blood disorder in which red blood cells contain methemoglobin, a form of hemoglobin that contains iron in its oxidized state, at levels >1%, often leading to a hypoxic state.	Iron	121-125	hemoglobin subunit gamma 2	Homo sapiens	71-84
35001811-3	2022	Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act as positive regulators of PRKN-independent mitophagy.	Iron	6-10	cyclin G associated kinase	Homo sapiens	163-166
35218933-3	2022	Thus, in response to iron deficiency, transcription factors Aft1 and Aft2 activate the expression of genes implicated in iron acquisition and mobilization, whereas two mRNA-binding proteins, Cth1 and Cth2, posttranscriptionally control iron metabolism.	Iron	121-125	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	60-64
35218933-3	2022	Thus, in response to iron deficiency, transcription factors Aft1 and Aft2 activate the expression of genes implicated in iron acquisition and mobilization, whereas two mRNA-binding proteins, Cth1 and Cth2, posttranscriptionally control iron metabolism.	Iron	236-240	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	60-64
35148163-0	2022	Erratum: Chiral Spin-Wave Velocities Induced by All-Garnet Interfacial Dzyaloshinskii-Moriya Interaction in Ultrathin Yttrium Iron Garnet Films (Phys.	Iron	126-130	spindlin 1	Homo sapiens	16-20
35075211-7	2022	Together, this data indicates M-CSF secretion supports a homeostatic iron recycling program that plays a key role in the maintenance of erythroid cells access to iron following burn injury.	Iron	162-166	colony stimulating factor 1 (macrophage)	Mus musculus	30-35
34614145-1	2022	The hormone erythroferrone (ERFE) is produced by erythroid cells in response to hemorrhage, hypoxia or other erythropoietic stimuli, and suppresses the hepatic production of the iron-regulatory hormone hepcidin, thereby mobilizing iron for erythropoiesis.	Iron	178-182	hepcidin antimicrobial peptide	Mus musculus	202-210
34614145-1	2022	The hormone erythroferrone (ERFE) is produced by erythroid cells in response to hemorrhage, hypoxia or other erythropoietic stimuli, and suppresses the hepatic production of the iron-regulatory hormone hepcidin, thereby mobilizing iron for erythropoiesis.	Iron	231-235	hepcidin antimicrobial peptide	Mus musculus	202-210
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	Cwp2p	Saccharomyces cerevisiae S288C	153-157
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	Wsc2p	Saccharomyces cerevisiae S288C	159-163
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	Gre1p	Saccharomyces cerevisiae S288C	227-231
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	337-341
35017613-6	2022	In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype.	Iron	299-303	siderophore transporter	Saccharomyces cerevisiae S288C	343-347
34997531-0	2022	Internalization and Decrease of Duodenal DMT1 Involved in Transient Suppression of Iron Uptake in Short-Acting Mucosal Block.	Iron	83-87	RoBo-1	Rattus norvegicus	41-45
34997531-3	2022	In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB.	Iron	47-51	RoBo-1	Rattus norvegicus	65-93
34997531-3	2022	In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB.	Iron	47-51	RoBo-1	Rattus norvegicus	95-99
35054318-2	2022	The ubiquitous FECH catalyzes the insertion of iron into the protoporphyrin ring to generate the final product, heme.	Iron	47-51	ferrochelatase	Homo sapiens	15-19
34911048-4	2022	In this work, trimetallic metal-organic frameworks Fe, Co, Ni-MOF (FCN-MOF) is in situ prepared on nickel foam (NF) and then used to make an electrochemical sensor in the detection of imidacloprid.	Iron	51-53	neurofascin	Homo sapiens	112-114
35008976-8	2022	We state the hypothesis that Tbeta4 is an endogenous iron chelator and take part in iron homeostasis in the ferroptosis process.	Iron	84-88	thymosin beta-4	Bos taurus	29-35
35574260-5	2022	Here, we use atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS) to measure the stability of protein neutrophil gelatinase-associated lipocalin (also known as NGAL, siderocalin, lipocalin 2) that can bind iron through the cation-pi interactions between its three cationic residues and the iron-binding tri-catechols.	Iron	229-233	lipocalin 2	Homo sapiens	125-167
35574260-5	2022	Here, we use atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS) to measure the stability of protein neutrophil gelatinase-associated lipocalin (also known as NGAL, siderocalin, lipocalin 2) that can bind iron through the cation-pi interactions between its three cationic residues and the iron-binding tri-catechols.	Iron	229-233	lipocalin 2	Homo sapiens	202-213
35574260-5	2022	Here, we use atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS) to measure the stability of protein neutrophil gelatinase-associated lipocalin (also known as NGAL, siderocalin, lipocalin 2) that can bind iron through the cation-pi interactions between its three cationic residues and the iron-binding tri-catechols.	Iron	313-317	lipocalin 2	Homo sapiens	125-167
35574260-5	2022	Here, we use atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS) to measure the stability of protein neutrophil gelatinase-associated lipocalin (also known as NGAL, siderocalin, lipocalin 2) that can bind iron through the cation-pi interactions between its three cationic residues and the iron-binding tri-catechols.	Iron	313-317	lipocalin 2	Homo sapiens	202-213
35574260-7	2022	Then, the same NGAL but bound with the iron-catechol complexes through the cation-pi interactions as a holo-form was characterized.	Iron	39-43	lipocalin 2	Homo sapiens	15-19
11981749-0	2002	Molecular aspects of iron absorption: Insights into the role of HFE in hemochromatosis.	Iron	21-25	homeostatic iron regulator	Homo sapiens	64-67
11981749-2	2002	HFE, the gene that is defective in the majority of cases, was identified in 1996 and, although the exact role that HFE plays in the uptake and utilization of iron is not yet clear, important aspects of HFE function are emerging.	Iron	158-162	homeostatic iron regulator	Homo sapiens	0-3
11981749-2	2002	HFE, the gene that is defective in the majority of cases, was identified in 1996 and, although the exact role that HFE plays in the uptake and utilization of iron is not yet clear, important aspects of HFE function are emerging.	Iron	158-162	homeostatic iron regulator	Homo sapiens	115-118
11981749-2	2002	HFE, the gene that is defective in the majority of cases, was identified in 1996 and, although the exact role that HFE plays in the uptake and utilization of iron is not yet clear, important aspects of HFE function are emerging.	Iron	158-162	homeostatic iron regulator	Homo sapiens	115-118
11983079-1	2002	The assembly of iron-sulfur (Fe-S) clusters is mediated by complex machinery which, in Escherichia coli, is encoded by the iscRSUA-hscBA-fdx-ORF3 gene cluster.	Iron	29-33	hypothetical protein	Escherichia coli	141-145
11983079-9	2002	Thus, the sequential association and dissociation among the IscS, IscU, IscA, HscB, HscA, Fdx, and ORF3 proteins may be a critical process in the assembly of Fe-S clusters.	Iron	158-162	hypothetical protein	Escherichia coli	99-103
12137229-9	2002	Examples include Friedreich ataxia where a mutation of a nuclear encoded protein (frataxin), probably involved in iron homeostasis in mitochondria, results in severe deficiency of the respiratory chain in a pattern indicative of free radical mediated damage.	Iron	114-118	frataxin	Homo sapiens	82-90
12023075-4	2002	Six half transporters are homologous to the yeast ATM1 mitochondrial protein, a finding which is in agreement with the hypothesis of a cryptic mitochondrion-derived compartment playing a role in the synthesis and transport of Fe-S clusters.	Iron	226-230	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	50-54
11969379-6	2002	The RNA-binding activities of IRP1 were selectively activated by clofibrate treatment even though liver iron concentration was not depleted.	Iron	104-108	aconitase 1	Rattus norvegicus	30-34
12069111-3	2002	The demonstration that deficit of frataxin in FRDA is associated with mitochondrial iron accumulation, increased sensitivity to oxidative stress, deficit of respiratory chain complex activities and in vivo impairment of cardiac and skeletal muscle tissue energy metabolism, has established FRDA as a "new" nuclear encoded mitochondrial disease.	Iron	84-88	frataxin	Homo sapiens	34-42
12069112-3	2002	Cells with low frataxin content display generalized deficiency of mitochondrial iron-sulfur cluster-containing proteins, which presumably denotes overproduction of superoxide radicals in these organelles.	Iron	80-84	frataxin	Homo sapiens	15-23
11925455-10	2002	Taken together, our results indicate that the iron-dependent regulation of m-acon in liver does not alter TCA cycle capacity but suggest that IRP-mediated changes in m-acon expression may modulate citrate use in other aspects of intermediary or iron metabolism.	Iron	245-249	caspase 3	Rattus norvegicus	142-145
11888608-0	2002	Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload.	Iron	15-19	homeostatic iron regulator	Homo sapiens	8-11
11888608-1	2002	Hereditary haemochromatosis is an iron overloading disorder caused by common mutations in the HFE gene.	Iron	34-38	homeostatic iron regulator	Homo sapiens	94-97
11888608-3	2002	We propose a molecular model in which HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron.	Iron	139-143	homeostatic iron regulator	Homo sapiens	38-41
11888608-5	2002	With this input, HFE enables the intestinal crypt cells and reticuloendothelial system to interpret the body"s iron requirements and regulate iron absorption and distribution.	Iron	111-115	homeostatic iron regulator	Homo sapiens	17-20
11888608-5	2002	With this input, HFE enables the intestinal crypt cells and reticuloendothelial system to interpret the body"s iron requirements and regulate iron absorption and distribution.	Iron	142-146	homeostatic iron regulator	Homo sapiens	17-20
11888608-6	2002	In our model, mutations in HFE result in over absorption of dietary iron, and patterns of tissue iron deposition in agreement with clinical observations of hereditary haemochromatosis.	Iron	68-72	homeostatic iron regulator	Homo sapiens	27-30
11888608-6	2002	In our model, mutations in HFE result in over absorption of dietary iron, and patterns of tissue iron deposition in agreement with clinical observations of hereditary haemochromatosis.	Iron	97-101	homeostatic iron regulator	Homo sapiens	27-30
11898957-9	2002	The HFE gene test is useful in confirming the diagnosis of hereditary hemochromatosis, screening adult family members of patients with HFE mutations and resolving ambiguities concerning iron overload.	Iron	186-190	homeostatic iron regulator	Homo sapiens	4-7
11850263-5	2002	Among the genes that were differentially expressed with chloroquine treatment were a number of metal transporters involved in iron acquisition (SIT1, ARN2, ARN4, and SMF2).	Iron	126-130	siderophore transporter	Saccharomyces cerevisiae S288C	150-154
11850263-5	2002	Among the genes that were differentially expressed with chloroquine treatment were a number of metal transporters involved in iron acquisition (SIT1, ARN2, ARN4, and SMF2).	Iron	126-130	Enb1p	Saccharomyces cerevisiae S288C	156-160
11869934-0	2002	H63D mutation in the HFE gene increases iron overload in beta-thalassemia carriers.	Iron	40-44	homeostatic iron regulator	Homo sapiens	21-24
11869934-7	2002	Differences in ferritin levels between homozygotes for H63D and wild type may indicate a modulator effect of the HFE mutation on iron absorption.	Iron	129-133	homeostatic iron regulator	Homo sapiens	113-116
11880554-3	2002	We therefore examined in rats how nutritional iron status would affect expression of ceruloplasmin.	Iron	46-50	ceruloplasmin	Rattus norvegicus	85-98
12006999-0	2002	[Preparation, characterization and receptor-binding capacity of pig serum transferrin half-molecules containing a single iron-binding site].	Iron	121-125	transferrin	Sus scrofa	74-85
12006999-1	2002	N- and C-half molecules containing a single iron-binding site were simultaneously obtained from trypsin digest of iron-saturated pig transferrin.	Iron	44-48	transferrin	Sus scrofa	133-144
12006999-1	2002	N- and C-half molecules containing a single iron-binding site were simultaneously obtained from trypsin digest of iron-saturated pig transferrin.	Iron	114-118	transferrin	Sus scrofa	133-144
11869803-7	2002	These results suggested that ferroxidase activity of hCP is essential for the hCP-mediated iron uptake process and also that CP-stimulated iron uptake is not associated with copper ions in the protein, and that the effect of ceruloplasmin on iron uptake by BT325 cells is not species specific.	Iron	91-95	coproporphyrinogen oxidase	Homo sapiens	53-56
11869803-7	2002	These results suggested that ferroxidase activity of hCP is essential for the hCP-mediated iron uptake process and also that CP-stimulated iron uptake is not associated with copper ions in the protein, and that the effect of ceruloplasmin on iron uptake by BT325 cells is not species specific.	Iron	91-95	coproporphyrinogen oxidase	Homo sapiens	78-81
11869803-7	2002	These results suggested that ferroxidase activity of hCP is essential for the hCP-mediated iron uptake process and also that CP-stimulated iron uptake is not associated with copper ions in the protein, and that the effect of ceruloplasmin on iron uptake by BT325 cells is not species specific.	Iron	91-95	coproporphyrinogen oxidase	Homo sapiens	54-56
11841228-6	2002	The fact that a dependent 6- to 5-coordinate nitrosyl conversion has been previously reported for soluble guanylate cyclase suggests that the mechanism of Fe-His bond cleavage may be similar to that of cytochrome c" and strengthens the recent proposal that both proteins exhibit proximal NO binding in their 5-coordinate nitrosyl adducts.	Iron	155-157	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	202-214
11960684-1	2002	The human transferrin receptor (TfR) and its ligand, the serum iron carrier transferrin, serve as a model system for endocytic receptors.	Iron	63-67	transferrin receptor	Homo sapiens	32-35
11807246-1	2002	Lactoferrin is an iron-binding protein.	Iron	18-22	inhibitor of carbonic anhydrase	Equus caballus	0-11
11823441-0	2002	Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia.	Iron	13-17	frataxin	Homo sapiens	46-54
11823441-2	2002	Mitochondrial iron accumulation, loss of iron-sulfur cluster-containing enzymes and increased oxidative damage occur in yeast and mouse frataxin-depleted mutants as well as tissues and cell lines from FRDA patients, suggesting that frataxin may be involved in export of iron from the mitochondria, synthesis of iron-sulfur clusters and/or protection from oxidative damage.	Iron	14-18	frataxin	Homo sapiens	232-240
11823441-3	2002	We have previously shown that yeast frataxin has structural and functional features of an iron storage protein.	Iron	90-94	frataxin	Homo sapiens	36-44
11823441-5	2002	When expressed in E.coli, the mature form of human frataxin assembles into a stable homopolymer that can bind approximately 10 atoms of iron per molecule of frataxin.	Iron	136-140	frataxin	Homo sapiens	51-59
11823441-5	2002	When expressed in E.coli, the mature form of human frataxin assembles into a stable homopolymer that can bind approximately 10 atoms of iron per molecule of frataxin.	Iron	136-140	frataxin	Homo sapiens	157-165
11823441-6	2002	The iron-loaded homopolymer can be detected on non-denaturing gels by either protein or iron staining demonstrating a stable association between frataxin and iron.	Iron	4-8	frataxin	Homo sapiens	145-153
11823441-6	2002	The iron-loaded homopolymer can be detected on non-denaturing gels by either protein or iron staining demonstrating a stable association between frataxin and iron.	Iron	88-92	frataxin	Homo sapiens	145-153
11823441-6	2002	The iron-loaded homopolymer can be detected on non-denaturing gels by either protein or iron staining demonstrating a stable association between frataxin and iron.	Iron	88-92	frataxin	Homo sapiens	145-153
11823441-10	2002	In radiolabeled yeast cells, human frataxin is recovered by immunoprecipitation with approximately five atoms of (55)Fe bound per molecule.	Iron	117-119	frataxin	Homo sapiens	35-43
11823441-11	2002	These findings suggest that FRDA results from decreased mitochondrial iron storage due to frataxin deficiency which may impair iron metabolism, promote oxidative damage and lead to progressive iron accumulation.	Iron	70-74	frataxin	Homo sapiens	90-98
11823441-11	2002	These findings suggest that FRDA results from decreased mitochondrial iron storage due to frataxin deficiency which may impair iron metabolism, promote oxidative damage and lead to progressive iron accumulation.	Iron	127-131	frataxin	Homo sapiens	90-98
11823441-11	2002	These findings suggest that FRDA results from decreased mitochondrial iron storage due to frataxin deficiency which may impair iron metabolism, promote oxidative damage and lead to progressive iron accumulation.	Iron	127-131	frataxin	Homo sapiens	90-98
11807826-0	2002	Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.	Iron	83-87	aconitase 1	Homo sapiens	10-14
11807826-0	2002	Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.	Iron	83-87	homeostatic iron regulator	Homo sapiens	96-99
11807826-3	2002	While HFE does not alter transferrin receptor trafficking or non-transferrin mediated iron uptake, it does specifically reduce (55)Fe uptake from transferrin (Roy et al., 1999, J Biol Chem 274:9022-9028).	Iron	131-133	homeostatic iron regulator	Homo sapiens	6-9
11807826-5	2002	Calcein measurements show a 45% decrease in the intracellular labile iron pool in HFE-expressing cells, which is in keeping with the IRP activation.	Iron	69-73	homeostatic iron regulator	Homo sapiens	82-85
11807826-5	2002	Calcein measurements show a 45% decrease in the intracellular labile iron pool in HFE-expressing cells, which is in keeping with the IRP activation.	Iron	69-73	Wnt family member 2	Homo sapiens	133-136
11807826-6	2002	These results all point to the direct effect of the interaction of HFE with transferrin receptor in lowering the intracellular labile iron pool and establishing a new set point for iron regulation within the cell.	Iron	134-138	homeostatic iron regulator	Homo sapiens	67-70
11807826-6	2002	These results all point to the direct effect of the interaction of HFE with transferrin receptor in lowering the intracellular labile iron pool and establishing a new set point for iron regulation within the cell.	Iron	181-185	homeostatic iron regulator	Homo sapiens	67-70
11714692-3	2002	We now observe formation of the internal loop/bulge (IL/B structure) in the IRE (iron-responsive element) of ferritin mRNA expressed in HeLa cells, using radical cleavage with Cu-phen (Cu-1,10-phenantholine), and protection of the loop/bulge by the regulatory protein (IRP), expressed by cotransfection.	Iron	81-85	Wnt family member 2	Homo sapiens	269-272
11779155-1	2002	Iron regulatory protein-1 (IRP-1) is known as a cytosolic aconitase and a central regulator of iron (Fe) homeostasis.	Iron	95-99	aconitase 1	Homo sapiens	0-25
11779155-1	2002	Iron regulatory protein-1 (IRP-1) is known as a cytosolic aconitase and a central regulator of iron (Fe) homeostasis.	Iron	95-99	aconitase 1	Homo sapiens	27-32
11779155-1	2002	Iron regulatory protein-1 (IRP-1) is known as a cytosolic aconitase and a central regulator of iron (Fe) homeostasis.	Iron	101-103	aconitase 1	Homo sapiens	0-25
11779155-1	2002	Iron regulatory protein-1 (IRP-1) is known as a cytosolic aconitase and a central regulator of iron (Fe) homeostasis.	Iron	101-103	aconitase 1	Homo sapiens	27-32
11779155-2	2002	IRP-1 regulates the expression of Fe metabolism-related proteins by interacting with the Fe-responsive element (IRE) in the untranslated regions of mRNAs of these proteins.	Iron	34-36	aconitase 1	Homo sapiens	0-5
11779155-2	2002	IRP-1 regulates the expression of Fe metabolism-related proteins by interacting with the Fe-responsive element (IRE) in the untranslated regions of mRNAs of these proteins.	Iron	89-91	aconitase 1	Homo sapiens	0-5
11779155-3	2002	However, it is less known whether IRP-1 modulates various non-Fe metals.	Iron	62-64	aconitase 1	Homo sapiens	34-39
11779155-4	2002	In the present study, we showed that treatment of homogenously purified IRP-1 with non-Fe metals decreased the affinity to IRE in RNA band shift assays and increased aconitase activity.	Iron	87-89	aconitase 1	Homo sapiens	72-77
11779155-5	2002	Non-Fe metals also inhibited (55)Fe incorporation into the fourth labile position of the Fe-S cluster of IRP-1.	Iron	4-6	aconitase 1	Homo sapiens	105-110
11779155-5	2002	Non-Fe metals also inhibited (55)Fe incorporation into the fourth labile position of the Fe-S cluster of IRP-1.	Iron	33-35	aconitase 1	Homo sapiens	105-110
11779155-5	2002	Non-Fe metals also inhibited (55)Fe incorporation into the fourth labile position of the Fe-S cluster of IRP-1.	Iron	33-35	aconitase 1	Homo sapiens	105-110
11779155-8	2002	These results suggest that various non-Fe metals modulate IRP-1 by conversion of the 3Fe-4S apo-form to a [1 non-Fe metal + 3Fe]-4Fe holo-form.	Iron	39-41	aconitase 1	Homo sapiens	58-63
11779155-8	2002	These results suggest that various non-Fe metals modulate IRP-1 by conversion of the 3Fe-4S apo-form to a [1 non-Fe metal + 3Fe]-4Fe holo-form.	Iron	86-88	aconitase 1	Homo sapiens	58-63
12401947-11	2002	The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards.	Iron	96-100	transferrin receptor	Rattus norvegicus	13-33
12401947-11	2002	The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards.	Iron	240-244	transferrin receptor	Rattus norvegicus	13-33
12401947-11	2002	The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards.	Iron	240-244	transferrin receptor	Rattus norvegicus	164-184
11718810-7	2002	Although iron level exhibited a slightly negative overall correlation (r(2)=0.119) with LPO results among the entire group of BXD RI strains, a sub-group with lower LPO values were highly correlated (r(2)=0.704).	Iron	9-13	lactoperoxidase	Mus musculus	88-91
11718810-8	2002	LPO results were also positively correlated with iron levels from a group of 8 other inbred mouse strains (r(2)=0.563).	Iron	49-53	lactoperoxidase	Mus musculus	0-3
11981450-1	2002	Iron regulatory proteins, IRP1 and IRP2, are cytoplasmic proteins of the iron-sulfur cluster isomerase family and serve as major post-transcriptional regulators of cellular iron metabolism.	Iron	0-4	aconitase 1	Homo sapiens	26-30
11981450-1	2002	Iron regulatory proteins, IRP1 and IRP2, are cytoplasmic proteins of the iron-sulfur cluster isomerase family and serve as major post-transcriptional regulators of cellular iron metabolism.	Iron	73-77	aconitase 1	Homo sapiens	26-30
11981450-1	2002	Iron regulatory proteins, IRP1 and IRP2, are cytoplasmic proteins of the iron-sulfur cluster isomerase family and serve as major post-transcriptional regulators of cellular iron metabolism.	Iron	173-177	aconitase 1	Homo sapiens	26-30
11981450-3	2002	IRP1 and IRP2 respond to alterations in intracellular iron levels, but also to other signals such as nitric oxide (NO) and reactive oxygen species (ROS).	Iron	54-58	aconitase 1	Homo sapiens	0-4
11981450-4	2002	The redox regulation of IRP1 and IRP2 provides direct links between the control of iron homeostasis and oxidative stress.	Iron	83-87	aconitase 1	Homo sapiens	24-28
11741608-7	2001	We propose that regulation of DCT1/DMT1 mRNA by iron involves post-transcriptional regulation through the binding of IRP1 to the transporter"s IRE, as well as other as yet unknown factors.	Iron	48-52	aconitase 1	Homo sapiens	117-121
11731422-5	2001	On the basis of such multiple comparisons, we characterized that DOXol was able to remove iron from the catalytic Fe-S cluster of cytoplasmic aconitase, making this enzyme switch to the cluster-free IRP-1.	Iron	90-94	aconitase 1	Rattus norvegicus	199-204
11581253-4	2001	Here, we demonstrate certain phenotypic differences between these strains: 1) lys7Delta cells are slightly less sensitive to paraquat than sod1Delta cells, 2) EPR-detectable or "free" iron is dramatically elevated in sod1Delta mutants but not in lys7Delta yeast, and 3) although sod1Delta mutants show increased sensitivity to extracellular zinc, the lys7Delta strain is as resistant as wild type.	Iron	184-188	copper chaperone CCS1	Saccharomyces cerevisiae S288C	78-87
11581253-4	2001	Here, we demonstrate certain phenotypic differences between these strains: 1) lys7Delta cells are slightly less sensitive to paraquat than sod1Delta cells, 2) EPR-detectable or "free" iron is dramatically elevated in sod1Delta mutants but not in lys7Delta yeast, and 3) although sod1Delta mutants show increased sensitivity to extracellular zinc, the lys7Delta strain is as resistant as wild type.	Iron	184-188	copper chaperone CCS1	Saccharomyces cerevisiae S288C	246-255
11581253-4	2001	Here, we demonstrate certain phenotypic differences between these strains: 1) lys7Delta cells are slightly less sensitive to paraquat than sod1Delta cells, 2) EPR-detectable or "free" iron is dramatically elevated in sod1Delta mutants but not in lys7Delta yeast, and 3) although sod1Delta mutants show increased sensitivity to extracellular zinc, the lys7Delta strain is as resistant as wild type.	Iron	184-188	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	139-143
11581253-4	2001	Here, we demonstrate certain phenotypic differences between these strains: 1) lys7Delta cells are slightly less sensitive to paraquat than sod1Delta cells, 2) EPR-detectable or "free" iron is dramatically elevated in sod1Delta mutants but not in lys7Delta yeast, and 3) although sod1Delta mutants show increased sensitivity to extracellular zinc, the lys7Delta strain is as resistant as wild type.	Iron	184-188	copper chaperone CCS1	Saccharomyces cerevisiae S288C	246-255
11734214-0	2001	Manganese superoxide dismutase induction by iron is impaired in Friedreich ataxia cells.	Iron	44-48	superoxide dismutase 2	Homo sapiens	0-30
11734214-0	2001	Manganese superoxide dismutase induction by iron is impaired in Friedreich ataxia cells.	Iron	44-48	frataxin	Homo sapiens	64-81
11734214-2	2001	Here, we show that normal upregulation of the stress defense protein manganese superoxide dismutase (MnSOD) fails to occur in FRDA fibroblasts exposed to iron.	Iron	154-158	superoxide dismutase 2	Homo sapiens	69-99
11729313-2	2001	The ScP waveforms can be modeled by thin (0.12 to 0.18 kilometer) zones of molten iron mixed with solid material with a small, but positive, S-wave velocity (0.6 to 0.8 kilometer per second) that enables the propagation of S-waves in the outermost core.	Iron	82-86	urocortin 3	Homo sapiens	4-7
11562378-2	2001	Siderophore-iron uptake can occur through the reduction of the complex and the subsequent uptake of iron by the high affinity iron transporter Fet3p/Ftr1p.	Iron	12-16	ferroxidase FET3	Saccharomyces cerevisiae S288C	143-148
11683635-1	2001	Acetogenic bacteria contain acetyl-CoA synthase (ACS), an enzyme with two distinct nickel-iron-sulfur active sites connected by a tunnel through which CO migrates.	Iron	90-94	acyl-CoA synthetase short chain family member 2	Homo sapiens	28-47
11683635-1	2001	Acetogenic bacteria contain acetyl-CoA synthase (ACS), an enzyme with two distinct nickel-iron-sulfur active sites connected by a tunnel through which CO migrates.	Iron	90-94	acyl-CoA synthetase short chain family member 2	Homo sapiens	49-52
11686732-0	2001	Sulfur transfer from IscS to IscU: the first step in iron-sulfur cluster biosynthesis.	Iron	53-57	NFS1 cysteine desulfurase	Homo sapiens	21-25
11709207-3	2001	Such increases in tissue iron content may be attributed to the stabilisation of IRP-2 by aluminium thereby promoting transferrin receptor synthesis while blocking ferritin synthesis.	Iron	25-29	transferrin receptor	Rattus norvegicus	117-137
11709209-2	2001	Transferrin receptors (TfR) in K562 cells are able to bind Tf, when carrying either iron (Fe) or Al, with similar affinity.	Iron	84-88	transferrin receptor	Homo sapiens	0-21
11709209-2	2001	Transferrin receptors (TfR) in K562 cells are able to bind Tf, when carrying either iron (Fe) or Al, with similar affinity.	Iron	84-88	transferrin receptor	Homo sapiens	23-26
11709209-2	2001	Transferrin receptors (TfR) in K562 cells are able to bind Tf, when carrying either iron (Fe) or Al, with similar affinity.	Iron	90-92	transferrin receptor	Homo sapiens	0-21
11709209-2	2001	Transferrin receptors (TfR) in K562 cells are able to bind Tf, when carrying either iron (Fe) or Al, with similar affinity.	Iron	90-92	transferrin receptor	Homo sapiens	23-26
11588054-0	2001	An IRP-like protein from Plasmodium falciparum binds to a mammalian iron-responsive element.	Iron	68-72	Wnt family member 2	Homo sapiens	3-6
11588054-1	2001	This study cloned and sequenced the complementary DNA (cDNA) encoding of a putative malarial iron responsive element-binding protein (PfIRPa) and confirmed its identity to the previously identified iron-regulatory protein (IRP)-like cDNA from Plasmodium falciparum.	Iron	93-97	Wnt family member 2	Homo sapiens	136-139
11588054-8	2001	These findings demonstrate that erythrocyte P falciparum contains an iron-regulated IRP that binds a mammalian consensus IRE sequence, raising the possibility that the malaria parasite expresses transcripts that contain IREs and are iron-dependently regulated.	Iron	69-73	Wnt family member 2	Homo sapiens	84-87
11588054-8	2001	These findings demonstrate that erythrocyte P falciparum contains an iron-regulated IRP that binds a mammalian consensus IRE sequence, raising the possibility that the malaria parasite expresses transcripts that contain IREs and are iron-dependently regulated.	Iron	233-237	Wnt family member 2	Homo sapiens	84-87
11479310-12	2001	Taken together our results indicate that the heme environment on the proximal side of nNOS is critical for the formation of a stable iron-cysteine bond and for the control of the electronic properties of heme-NO complexes.	Iron	53-57	nitric oxide synthase 1	Homo sapiens	86-90
11935367-5	2001	The ability to protect or restore 5"-nucleotidase activity and to diminish chain-induced lipid peroxidation is explicable in terms of: metal-binding ability, capacity of taking iron away from a biological molecule, or ability of transferring the damage to itself.	Iron	177-181	5' nucleotidase, ecto	Rattus norvegicus	34-49
11568090-2	2001	Individuals with mutations in the HFE gene may have increased serum iron, transferrin saturation, and ferritin concentrations relative to individuals with the wild-type genotype.	Iron	68-72	homeostatic iron regulator	Homo sapiens	34-37
11589765-10	2001	An elevated serum ferritin level, which was correlated with TS, indicates that iron-induced oxidative stress contributes to CH-C.	Iron	79-83	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	124-128
11546828-5	2001	We have moreover carried out a molecular analysis of candidate genes (beta(2)-microglobulin, HFE, and haem oxygenases 1 and 2) implicated in iron metabolism.	Iron	141-145	homeostatic iron regulator	Homo sapiens	93-96
11554454-11	2001	Data suggest (a) each HRM can contribute to HO-2-heme interaction, (b) heme iron interacts with cysteine thiol, (c) charged residues upstream of Cys264-Pro265 result in its high-affinity heme binding, and (d) inhibition of HO-2 activity by synthetic metalloporphyrins does not involve HRMs.	Iron	76-80	heme oxygenase 2	Homo sapiens	44-48
11554454-11	2001	Data suggest (a) each HRM can contribute to HO-2-heme interaction, (b) heme iron interacts with cysteine thiol, (c) charged residues upstream of Cys264-Pro265 result in its high-affinity heme binding, and (d) inhibition of HO-2 activity by synthetic metalloporphyrins does not involve HRMs.	Iron	76-80	heme oxygenase 2	Homo sapiens	223-227
11469807-0	2001	Cloning of Pichia pastoris Fet3: insights into the high affinity iron uptake system.	Iron	65-69	ferroxidase FET3	Saccharomyces cerevisiae S288C	27-31
11469807-1	2001	High-affinity iron uptake by yeast cells appears to require the presence of a complex formed on the plasma membrane by the multicopper oxidase Fet3 and the permease Ftr1 which work together to allow iron to enter safely inside the cell.	Iron	14-18	ferroxidase FET3	Saccharomyces cerevisiae S288C	143-147
11469807-1	2001	High-affinity iron uptake by yeast cells appears to require the presence of a complex formed on the plasma membrane by the multicopper oxidase Fet3 and the permease Ftr1 which work together to allow iron to enter safely inside the cell.	Iron	199-203	ferroxidase FET3	Saccharomyces cerevisiae S288C	143-147
11469807-2	2001	The Pichia pastoris ferroxidase Fet3 has been cloned and it has been found to display high sequence similarity to other yeast multicopper oxidases, including all the predicted ligands for the catalytic copper atoms and for the iron substrate.	Iron	227-231	ferroxidase FET3	Saccharomyces cerevisiae S288C	32-36
11463361-0	2001	Treatment of PC12 cells with nerve growth factor increases iron uptake.	Iron	59-63	nerve growth factor	Rattus norvegicus	29-48
11463361-2	2001	Here we compare the uptake of transferrin-bound and non-transferrin-bound iron in NGF-treated (neuronal phenotype) and control (proliferating) PC12 cells.	Iron	74-78	nerve growth factor	Rattus norvegicus	82-85
11463361-3	2001	The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the iron-chelating agents used, the oxidation state of iron (Fe(2+) or Fe(3+)) and the iron concentration tested.	Iron	26-30	nerve growth factor	Rattus norvegicus	57-60
11463361-3	2001	The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the iron-chelating agents used, the oxidation state of iron (Fe(2+) or Fe(3+)) and the iron concentration tested.	Iron	134-138	nerve growth factor	Rattus norvegicus	57-60
11463361-3	2001	The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the iron-chelating agents used, the oxidation state of iron (Fe(2+) or Fe(3+)) and the iron concentration tested.	Iron	134-138	nerve growth factor	Rattus norvegicus	57-60
11463361-3	2001	The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the iron-chelating agents used, the oxidation state of iron (Fe(2+) or Fe(3+)) and the iron concentration tested.	Iron	191-193	nerve growth factor	Rattus norvegicus	57-60
11463361-3	2001	The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the iron-chelating agents used, the oxidation state of iron (Fe(2+) or Fe(3+)) and the iron concentration tested.	Iron	201-203	nerve growth factor	Rattus norvegicus	57-60
11463361-3	2001	The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the iron-chelating agents used, the oxidation state of iron (Fe(2+) or Fe(3+)) and the iron concentration tested.	Iron	134-138	nerve growth factor	Rattus norvegicus	57-60
11592396-5	2001	We have inserted the IRE (iron responsive element) sequence into the construct and have used in vitro transcripts to study binding of IRE-BP.	Iron	26-30	aconitase 1	Homo sapiens	134-140
11445863-0	2001	CD71 antibody enhances iron uptake by mouse bone marrow cells and the survival potential of erythroid progenitor cells.	Iron	23-27	transferrin receptor	Mus musculus	0-4
11447267-2	2001	We report here a peculiar phenotype of Usf2(-/-) mice that progressively develop multivisceral iron overload; plasma iron overcomes transferrin binding capacity, and nontransferrin-bound iron accumulates in various tissues including pancreas and heart.	Iron	95-99	upstream transcription factor 2	Mus musculus	39-43
11447267-2	2001	We report here a peculiar phenotype of Usf2(-/-) mice that progressively develop multivisceral iron overload; plasma iron overcomes transferrin binding capacity, and nontransferrin-bound iron accumulates in various tissues including pancreas and heart.	Iron	117-121	upstream transcription factor 2	Mus musculus	39-43
11447267-2	2001	We report here a peculiar phenotype of Usf2(-/-) mice that progressively develop multivisceral iron overload; plasma iron overcomes transferrin binding capacity, and nontransferrin-bound iron accumulates in various tissues including pancreas and heart.	Iron	117-121	upstream transcription factor 2	Mus musculus	39-43
11517632-6	2001	Also, we now know that a significant number of asymptomatic people carry the hemochromatosis gene, HFE, indicating that these people have the potential to accumulate excess body iron in their lifetime.	Iron	178-182	homeostatic iron regulator	Homo sapiens	99-102
11795592-5	2001	Importantly, the classical features of regulation by iron and oxygen availability are reflected in regulation of the HIF-alpha/pVHL interaction.	Iron	53-57	von Hippel-Lindau tumor suppressor	Homo sapiens	127-131
11432781-2	2001	In bacteria, several proteins encoded by the iscRSUA-hscBA-fdx-ORF3 cluster (isc operon) have been proposed to execute crucial tasks in the assembly of Fe-S clusters.	Iron	152-156	hypothetical protein	Escherichia coli	63-67
11297549-1	2001	The expression of several proteins with critical functions in iron metabolism is regulated post-transcriptionally by the binding of iron regulatory proteins, IRP1 and IRP2, to mRNA iron responsive elements (IREs).	Iron	62-66	aconitase 1	Rattus norvegicus	158-162
11297549-1	2001	The expression of several proteins with critical functions in iron metabolism is regulated post-transcriptionally by the binding of iron regulatory proteins, IRP1 and IRP2, to mRNA iron responsive elements (IREs).	Iron	132-136	aconitase 1	Rattus norvegicus	158-162
11297549-1	2001	The expression of several proteins with critical functions in iron metabolism is regulated post-transcriptionally by the binding of iron regulatory proteins, IRP1 and IRP2, to mRNA iron responsive elements (IREs).	Iron	132-136	aconitase 1	Rattus norvegicus	158-162
11297549-2	2001	In iron-deficient tissues and cultured cells, both IRP1 and IRP2 are activated for high affinity IRE binding.	Iron	3-7	aconitase 1	Rattus norvegicus	51-55
11396936-0	2001	Iron extraction from soybean lipoxygenase 3 and reconstitution of catalytic activity from the apoenzyme.	Iron	0-4	seed linoleate 9S-lipoxygenase-3	Glycine max	29-43
11351269-13	2001	Iron is accumulated in the mitochondrial matrix of both the yeast frataxin deficient mutant and the patient fibroblasts.	Iron	0-4	frataxin	Homo sapiens	66-74
11351269-14	2001	It has been postulated that iron-induced oxygen radical affects the oxidative phosphorylation in frataxin deficiency states favouring the disease pathology.	Iron	28-32	frataxin	Homo sapiens	97-105
11343803-7	2001	To further probe the relevance of sulfide in the mobilization of iron, several enzymes, such as NifS, rhodanese, or sulfite reductase generating reduced forms of sulfur by different mechanisms, have been assayed for their ability to catalyze the release of iron from ferritin.	Iron	65-69	NFS1 cysteine desulfurase	Homo sapiens	96-100
11427792-16	2001	This iron overload due to HFE mutations is a new triggering factor of porphyria cutanea tarda independent of classical triggering factors: mutation of the erythrocytic uroporpyrinogen decarbocylase gene, alcohol abuse, hepatitis C, and drugs.	Iron	5-9	homeostatic iron regulator	Homo sapiens	26-29
11309500-0	2001	Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice.	Iron	74-78	beta-2 microglobulin	Mus musculus	91-111
11306436-4	2001	Iron loading also increased gene expression of platelet-derived growth factor (PDGF)-A and transforming growth factor (TGF)-beta(1).	Iron	0-4	platelet derived growth factor subunit A	Rattus norvegicus	79-86
11421280-4	2001	The Atm1p-like proteins perform an important function in mitochondrial iron homeostasis and in the maturation of Fe/S proteins in the cytosol.	Iron	71-75	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	4-9
11260010-2	2001	The aetiology of this iron overload remains unknown; however, it has been demonstrated that mutations of HFE, the genetic haemochromatosis gene, might be present in a significant proportion of Anglo-Saxon and Italian patients.	Iron	22-26	homeostatic iron regulator	Homo sapiens	105-108
11222606-7	2001	Iron-mediated regulation of these promoters through the repressor protein Fur is a consequence of the relative promoter strengths and the position of an operator site that consists of two overlapping Fur-binding sequences in this compact regulatory region.	Iron	0-4	repressor	Escherichia coli	56-65
11260522-0	2001	Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor.	Iron	8-12	transferrin receptor	Homo sapiens	102-122
11260522-5	2001	In non-polarized cells, the partnership of HFE and TfR results in decreased iron uptake into cells.	Iron	76-80	homeostatic iron regulator	Homo sapiens	43-46
11260522-5	2001	In non-polarized cells, the partnership of HFE and TfR results in decreased iron uptake into cells.	Iron	76-80	transferrin receptor	Homo sapiens	51-54
11085979-4	2001	Data presented here demonstrate for the first time that the cytoplasmic form of Arabidopsis glyoxalase II contains an iron-zinc binuclear metal center that is essential for activity.	Iron	118-122	glyoxalase 2-1	Arabidopsis thaliana	92-105
11159549-4	2001	The expression and subcellular localization of DMT1 protein in 3 mouse models of iron overload were examined: hypotransferrinemic (Trf(hpx)) mice, Hfe knockout mice, and B2m knockout mice.	Iron	81-85	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	47-51
11159549-6	2001	This suggests that DMT1 expression is increased in response to iron deficiency in the erythron, even in the setting of systemic iron overload.	Iron	63-67	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	19-23
11159549-6	2001	This suggests that DMT1 expression is increased in response to iron deficiency in the erythron, even in the setting of systemic iron overload.	Iron	128-132	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	19-23
11180391-0	2001	Iron-Catalyzed Regio- and Stereoselective Carbolithiation of Alkynes This work was partly supported by Grants-in-Aid for Scientific Research and Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture, Japan.	Iron	0-4	activation induced cytidine deaminase	Homo sapiens	113-116
11180391-0	2001	Iron-Catalyzed Regio- and Stereoselective Carbolithiation of Alkynes This work was partly supported by Grants-in-Aid for Scientific Research and Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture, Japan.	Iron	0-4	activation induced cytidine deaminase	Homo sapiens	155-158
11232708-5	2001	METHODS: This study included only hemochromatosis patients who were homozygotes for the C282Y mutation of the HFE gene and had undergone liver biopsy with hepatic iron concentration.	Iron	163-167	homeostatic iron regulator	Homo sapiens	110-113
11236924-8	2001	Yields of damage in PCC collected 48 h after irradiation with iron particles were similar to values obtained from cells undergoing mitosis after prolonged incubation.	Iron	62-66	crystallin gamma D	Homo sapiens	20-23
11207374-7	2001	Recent identification and characterization of the hemochromatosis protein HFE, the iron importer Nramp2, the iron exporter ferroportin1, and the second transferrin-binding and -transport protein transferrin receptor 2, have demonstrated their important roles in maintaining body"s iron homeostasis.	Iron	83-87	homeostatic iron regulator	Homo sapiens	74-77
11207374-7	2001	Recent identification and characterization of the hemochromatosis protein HFE, the iron importer Nramp2, the iron exporter ferroportin1, and the second transferrin-binding and -transport protein transferrin receptor 2, have demonstrated their important roles in maintaining body"s iron homeostasis.	Iron	109-113	homeostatic iron regulator	Homo sapiens	74-77
11960574-7	2001	We conclude that most physicians who submitted specimens identify patients by phenotyping who have greater frequencies of "typical" hemochromatosis-associated HFE genotypes than controls, and that HFE mutation testing is useful in detecting hemochromatosis in family members of persons with hemochromatosis or iron overload.	Iron	310-314	homeostatic iron regulator	Homo sapiens	197-200
11960576-3	2001	We provide a guideline for genetic counseling in HFE-linked hemochromatosis based on the genetic probability of inheriting HFE mutations and known information about expression of iron overload in various HFE genotypes.	Iron	179-183	homeostatic iron regulator	Homo sapiens	49-52
11960576-7	2001	The probability of inheriting HFE mutations and developing iron overload can be estimated in family members of a proband with HFE mutations.	Iron	59-63	homeostatic iron regulator	Homo sapiens	126-129
11167127-0	2001	Frataxin: its role in iron metabolism and the pathogenesis of Friedreich"s ataxia.	Iron	22-26	frataxin	Homo sapiens	0-8
11123951-0	2000	Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori.	Iron	38-42	NFS1 cysteine desulfurase	Homo sapiens	33-37
11123951-1	2000	The Fe-S cluster formation proteins NifU and NifS are essential for viability in the ulcer causing human pathogen Helicobacter pylori.	Iron	4-8	NFS1 cysteine desulfurase	Homo sapiens	45-49
11123951-10	2000	NifS is a cysteine desulfurase, releasing sulfur or sulfide (depending on the reducing environment) from L-cysteine, in agreement with its proposed role as a sulfur donor to Fe-S clusters.	Iron	174-178	NFS1 cysteine desulfurase	Homo sapiens	0-4
11123951-11	2000	The results here indicate that the NifU type of Fe-S cluster formation proteins is not specific for maturation of the nitrogenase proteins and, as H. pylori lacks other Fe-S cluster assembly proteins, that the H. pylori NifS and NifU are responsible for the assembly of many (non-nitrogenase) Fe-S clusters.	Iron	48-52	NFS1 cysteine desulfurase	Homo sapiens	220-224
11123951-11	2000	The results here indicate that the NifU type of Fe-S cluster formation proteins is not specific for maturation of the nitrogenase proteins and, as H. pylori lacks other Fe-S cluster assembly proteins, that the H. pylori NifS and NifU are responsible for the assembly of many (non-nitrogenase) Fe-S clusters.	Iron	169-173	NFS1 cysteine desulfurase	Homo sapiens	220-224
11106561-0	2000	Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1.	Iron	0-4	beta-2 microglobulin	Mus musculus	60-79
11090085-6	2000	Immunohistochemical analyses show that, as for normal mice on a low-iron diet, DMT1 expression in enterocytes of mk/mk mice is restricted to the duodenum.	Iron	68-72	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	79-83
11090085-10	2000	This is consistent with a feedback regulation of DMT1 expression by iron stores.	Iron	68-72	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	49-53
11114141-5	2000	Nevertheless, it is advisable to  search for this mutation in cases with iron overload and  heterozygosity for the C282Y or H63D mutations of the HFE  gene.	Iron	73-77	homeostatic iron regulator	Homo sapiens	146-149
11087382-10	2000	In the CO complex, the Fe-CO stretching frequency at 493 cm(-1) suggests an open heme pocket, which is consistent with the higher on- and off-rates for CO relative to those in myoglobin.	Iron	23-25	myoglobin	Physeter catodon	176-185
11063448-5	2000	TfR and TfR:SF were significantly correlated with the other laboratory indicators of iron status.	Iron	85-89	transferrin receptor	Homo sapiens	0-3
11063448-5	2000	TfR and TfR:SF were significantly correlated with the other laboratory indicators of iron status.	Iron	85-89	transferrin receptor	Homo sapiens	8-11
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	101-105	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	4-54
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	101-105	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	56-62
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	107-109	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	4-54
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	107-109	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	56-62
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	163-165	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	4-54
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	163-165	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	56-62
11054110-12	2000	These results are of interest as the TfR and Nramp2 are thought to act together during Fe uptake from Tf.	Iron	87-89	transferrin receptor	Mus musculus	37-40
11054110-12	2000	These results are of interest as the TfR and Nramp2 are thought to act together during Fe uptake from Tf.	Iron	87-89	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	45-51
11139688-0	2000	[Genotyping of the mutation of hemochromatosis HFE gene in a series of more than one thousand patients with serum iron overload].	Iron	114-118	homeostatic iron regulator	Homo sapiens	47-50
11114371-0	2000	HFE--a novel nonclassical class I molecule that is involved in iron metabolism.	Iron	63-67	homeostatic iron regulator	Homo sapiens	0-3
11095929-2	2000	Whereas transferrin receptor (TfR) is responsible for iron uptake from maternal serum by the syncytiotrophoblast, the proteins responsible for intracytoplasmic transport and for delivery to the fetal serum remain unknown.	Iron	54-58	transferrin receptor	Homo sapiens	8-28
11095929-2	2000	Whereas transferrin receptor (TfR) is responsible for iron uptake from maternal serum by the syncytiotrophoblast, the proteins responsible for intracytoplasmic transport and for delivery to the fetal serum remain unknown.	Iron	54-58	transferrin receptor	Homo sapiens	30-33
10930410-10	2000	The iron uptake resulting from expression of Smf1p and Smf2p was analyzed in a mutant in which its iron transporters FET3 and FET4 were inactivated.	Iron	4-8	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	45-50
10930410-11	2000	Overexpression of Smf1p gave rise to a significant iron uptake that was sensitive to the sodium concentrations in the medium.	Iron	51-55	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	18-23
10930410-12	2000	We conclude that the Smf proteins play a major role in copper and manganese homeostasis and, under certain circumstances, Smf1p may function in iron transport into the cells.	Iron	144-148	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	122-127
10889193-1	2000	Intracellular iron homeostasis is regulated, in part, by interactions between iron-regulatory proteins (IRP1 and IRP2) and iron-responsive elements (IREs) in ferritin and transferrin receptor mRNAs.	Iron	14-18	aconitase 1	Rattus norvegicus	104-108
11051367-0	2000	Prevalence and clinical significance of HFE gene mutations in patients with iron overload.	Iron	76-80	homeostatic iron regulator	Homo sapiens	40-43
10901255-0	2000	Adsorption/desorption properties of copper ions on the surface of iron-coated sand using BET and EDAX analyses.	Iron	66-70	delta/notch like EGF repeat containing	Homo sapiens	89-92
11005792-2	2000	The identification of HFE, the principal determinant of adult haemochromatosis (HFE1; OMIM 235200) and TfR2, recently implicated in a rarer form of the inherited disorder (HFE3; OMIM 604250), and the promise of candidate genes for juvenile haemochromatosis (HFE2; OMIM 602390) and neonatal haemochromatosis (OMIM 231100) provide the foundation for important studies into the control mechanism of iron balance in humans.	Iron	396-400	homeostatic iron regulator	Homo sapiens	22-25
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	103-107	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	164-168
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	148-152	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	164-168
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	148-152	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	164-168
11005792-4	2000	Gene mapping studies in animal mutants with anaemia due to defects in the uptake or tissue transfer of iron have yielded novel proteins involved in iron transport: DMT1 (brush border transporter of ferrous iron) in the mk/mk mouse, hephaestin (basolateral multi-copper ferroxidase) in the sex-linked anaemic mouse (sla) and ferroportin1 (basolateral iron exporter) in zebrafish weh mutants.	Iron	148-152	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	164-168
11018711-3	2000	Structural studies of the protein product of the HFE gene are of major interest for a better understanding of the molecular physiopathology in iron overload.	Iron	143-147	homeostatic iron regulator	Homo sapiens	49-52
10875932-8	2000	In conclusion, serine 349, located in the three-dimensional structure lining the active site and involved in the structural maintenance of the iron binding site, is essential for the structural stability and assembly and also for the catalytic properties of the PAH enzyme, whereas the L348V and V388M mutations affect the folding properties and stability of the protein.	Iron	143-147	phenylalanine hydroxylase	Homo sapiens	262-265
10979877-0	2000	The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic.	Iron	47-51	homeostatic iron regulator	Homo sapiens	14-17
10966897-1	2000	BACKGROUND: Divalent metal transporter 1 (DMT1), HFE, and stimulator of iron transport (SFT) are transmembrane proteins that have been implicated in the regulation of iron homeostasis.	Iron	72-76	homeostatic iron regulator	Homo sapiens	49-52
10966897-1	2000	BACKGROUND: Divalent metal transporter 1 (DMT1), HFE, and stimulator of iron transport (SFT) are transmembrane proteins that have been implicated in the regulation of iron homeostasis.	Iron	167-171	homeostatic iron regulator	Homo sapiens	49-52
10966897-2	2000	OBJECTIVE: The objective of this study was to investigate whether absorption and transepithelial movement of iron correlated with gene expression of DMT1, HFE, and SFT in an experimental model of human absorptive enterocytes.	Iron	109-113	homeostatic iron regulator	Homo sapiens	155-158
10966897-5	2000	In the absence of serum, iron treatment was associated with a reduction of DMT1 expression by 50% at 72 and 168 h. HFE expression was dependent on serum, but iron treatment did not alter HFE expression.	Iron	25-29	homeostatic iron regulator	Homo sapiens	115-118
10956029-2	2000	Under conditions of high iron concentration, DtxR binds the tox operator to inhibit transcription.	Iron	25-29	thymocyte selection associated high mobility group box	Homo sapiens	60-63
10910932-0	2000	Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.	Iron	45-49	homeostatic iron regulator	Homo sapiens	10-13
10910932-4	2000	The role of HFE in iron metabolism and the basis for the phenotypic abnormalities of HC are not understood.	Iron	19-23	homeostatic iron regulator	Homo sapiens	12-15
10910932-10	2000	These results suggest that the iron-deficient phenotype of HC macrophages is a direct effect of the HFE mutation, and they demonstrate a role for HFE in the accumulation of iron in these cells.	Iron	31-35	homeostatic iron regulator	Homo sapiens	100-103
10910932-10	2000	These results suggest that the iron-deficient phenotype of HC macrophages is a direct effect of the HFE mutation, and they demonstrate a role for HFE in the accumulation of iron in these cells.	Iron	173-177	homeostatic iron regulator	Homo sapiens	146-149
10925986-0	2000	Histological evaluation of iron in liver biopsies: relationship to HFE mutations.	Iron	27-31	homeostatic iron regulator	Homo sapiens	67-70
10925986-2	2000	Hereditary hemochromatosis (HH) results in hepatic iron overload and is associated with 2 missense mutations in the HFE gene.	Iron	51-55	homeostatic iron regulator	Homo sapiens	116-119
10925986-3	2000	The aim of this study was to define the usefulness of the histological pattern of iron deposition in determining the probability of an iron-loaded patient having HFE-related iron overload.	Iron	82-86	homeostatic iron regulator	Homo sapiens	162-165
10925986-3	2000	The aim of this study was to define the usefulness of the histological pattern of iron deposition in determining the probability of an iron-loaded patient having HFE-related iron overload.	Iron	135-139	homeostatic iron regulator	Homo sapiens	162-165
10925986-3	2000	The aim of this study was to define the usefulness of the histological pattern of iron deposition in determining the probability of an iron-loaded patient having HFE-related iron overload.	Iron	135-139	homeostatic iron regulator	Homo sapiens	162-165
10925986-10	2000	CONCLUSIONS: The use of histological evaluation for iron deposition is simple, assists in expanding information communicated from histopathologic observations, and may be clinically useful in determining the necessity of further evaluation of HFE genotype in subjects with histological evidence of hepatic iron overload.	Iron	52-56	homeostatic iron regulator	Homo sapiens	243-246
11229523-9	2000	Redox processes at the cell surface, which generate cuprous ions, are involved in the regulation of the MT-1 and HO-1 genes by heme-hemopexin before heme catabolism and intracellular release of iron.	Iron	194-198	hemopexin	Homo sapiens	132-141
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	14-18	transferrin receptor	Rattus norvegicus	119-139
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	14-18	transferrin receptor	Rattus norvegicus	141-144
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	73-77	transferrin receptor	Rattus norvegicus	119-139
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	73-77	transferrin receptor	Rattus norvegicus	141-144
10805735-0	2000	Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis.	Iron	50-54	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	33-37
10805735-6	2000	An inspection of Isa-like proteins from bacteria to mammals revealed three invariant cysteine residues, which in the case of Isa1p and Isa2p are essential for function and may be involved in iron binding.	Iron	191-195	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	125-130
10805735-11	2000	A model for the nonredundant roles of Isa1p and Isa2p in delivering iron to sites of the Fe-S cluster assembly is discussed.	Iron	68-72	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	38-43
10805735-11	2000	A model for the nonredundant roles of Isa1p and Isa2p in delivering iron to sites of the Fe-S cluster assembly is discussed.	Iron	89-93	Fe-binding Fe/S cluster assembly protein ISA1	Saccharomyces cerevisiae S288C	38-43
10809751-0	2000	A mammalian iron ATPase induced by iron.	Iron	12-16	dynein axonemal heavy chain 8	Homo sapiens	17-23
10854101-1	2000	The identification of mutations in the haemochromatosis gene (HFE) (C282Y and H63D) provides the unique opportunity to test whether genetic variants that are associated with tissue iron accumulation may influence the risk of coronary atherosclerosis.	Iron	181-185	homeostatic iron regulator	Homo sapiens	62-65
10766782-3	2000	In this work, we observed that addition of iron improved the respiratory growth of the sod1 mutant and in glucose medium total intracellular iron content was higher in the sod1 mutant than in wild type cells.	Iron	43-47	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	87-91
10766782-3	2000	In this work, we observed that addition of iron improved the respiratory growth of the sod1 mutant and in glucose medium total intracellular iron content was higher in the sod1 mutant than in wild type cells.	Iron	43-47	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	172-176
10771090-2	2000	In order to elucidate the role of HFE protein on cellular iron metabolism, functional studies were carried out in human hepatoma cells (HLF) overexpressing a fusion gene of HFE and green fluorescent protein (GFP).	Iron	58-62	homeostatic iron regulator	Homo sapiens	34-37
10771090-6	2000	In the transfectants, HFE protein decreased the rate of transferrin receptor-dependent iron ((59)Fe) uptake by the cells, but did not change the rate of iron release, indicating that HFE protein decreased the rate of iron influx.	Iron	87-91	homeostatic iron regulator	Homo sapiens	22-25
10771090-6	2000	In the transfectants, HFE protein decreased the rate of transferrin receptor-dependent iron ((59)Fe) uptake by the cells, but did not change the rate of iron release, indicating that HFE protein decreased the rate of iron influx.	Iron	97-99	homeostatic iron regulator	Homo sapiens	22-25
10771090-11	2000	Our results strongly suggest an additional role of HFE on transferrin receptor recycling in addition to the decrease of receptor affinity, resulting in the reduced cellular iron.	Iron	173-177	homeostatic iron regulator	Homo sapiens	51-54
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	132-136	metalloendopeptidase	Saccharomyces cerevisiae S288C	103-107
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	132-136	frataxin	Homo sapiens	284-292
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	metalloendopeptidase	Saccharomyces cerevisiae S288C	103-107
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	frataxin	Homo sapiens	284-292
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	metalloendopeptidase	Saccharomyces cerevisiae S288C	103-107
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	frataxin	Homo sapiens	284-292
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	metalloendopeptidase	Saccharomyces cerevisiae S288C	103-107
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	frataxin	Homo sapiens	284-292
10767311-3	2000	Yeast knock-out models and histological data from patient heart autopsies have shown that frataxin defect causes mitochondrial iron accumulation.	Iron	127-131	frataxin	Homo sapiens	90-98
10767311-5	2000	These results suggest that frataxin may play a role either in mitochondrial iron transport or in iron-sulfur cluster assembly or transport.	Iron	76-80	frataxin	Homo sapiens	27-35
10767311-5	2000	These results suggest that frataxin may play a role either in mitochondrial iron transport or in iron-sulfur cluster assembly or transport.	Iron	97-101	frataxin	Homo sapiens	27-35
10744769-7	2000	Deletion of ARN3 did not prevent yeast from using ferrioxamine B as an iron source; however, deletion of ARN3 and FET3, a component of the high affinity ferrous iron transport system, did prevent uptake of ferrioxamine-bound iron and growth on ferrioxamine as an iron source.	Iron	161-165	ferroxidase FET3	Saccharomyces cerevisiae S288C	114-118
10744769-7	2000	Deletion of ARN3 did not prevent yeast from using ferrioxamine B as an iron source; however, deletion of ARN3 and FET3, a component of the high affinity ferrous iron transport system, did prevent uptake of ferrioxamine-bound iron and growth on ferrioxamine as an iron source.	Iron	161-165	ferroxidase FET3	Saccharomyces cerevisiae S288C	114-118
10744769-7	2000	Deletion of ARN3 did not prevent yeast from using ferrioxamine B as an iron source; however, deletion of ARN3 and FET3, a component of the high affinity ferrous iron transport system, did prevent uptake of ferrioxamine-bound iron and growth on ferrioxamine as an iron source.	Iron	161-165	ferroxidase FET3	Saccharomyces cerevisiae S288C	114-118
10763957-0	2000	Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. OBJECTIVES: Hepatic iron deposition has been reported in chronic hepatitis C (CH-C), and iron-induced lipid peroxidation may be involved in the pathogenesis of CH-C.	Iron	141-145	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	199-203
10763957-0	2000	Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. OBJECTIVES: Hepatic iron deposition has been reported in chronic hepatitis C (CH-C), and iron-induced lipid peroxidation may be involved in the pathogenesis of CH-C.	Iron	141-145	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	281-285
10763957-0	2000	Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. OBJECTIVES: Hepatic iron deposition has been reported in chronic hepatitis C (CH-C), and iron-induced lipid peroxidation may be involved in the pathogenesis of CH-C.	Iron	141-145	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	199-203
10763957-0	2000	Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. OBJECTIVES: Hepatic iron deposition has been reported in chronic hepatitis C (CH-C), and iron-induced lipid peroxidation may be involved in the pathogenesis of CH-C.	Iron	141-145	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	281-285
10739755-1	2000	The aim of this study was to assess and to compare the role of HFE polymorphisms and other genetic factors in variation in iron stores.	Iron	123-127	homeostatic iron regulator	Homo sapiens	63-66
10739755-10	2000	We conclude that HFE CY and HD heterozygotes differ in iron status from the CC and HH homozygotes and that serum transferrin saturation is more affected than is serum ferritin.	Iron	55-59	homeostatic iron regulator	Homo sapiens	17-20
11001625-1	2000	The MHC class I-related HFE gene appears to be involved in iron metabolism, but its pathogenic mechanism in hemochromatosis remains unknown.	Iron	59-63	homeostatic iron regulator	Homo sapiens	24-27
10756357-1	2000	BACKGROUND AND OBJECTIVE: HFE is a class-I MHC related protein which carries the C282Y mutation in most patients with hereditary hemochromatosis, an iron overload disease.	Iron	149-153	homeostatic iron regulator	Homo sapiens	26-29
10756357-2	2000	HFE protein is expected to have a relevant role in the regulation of duodenal iron absorption, and HFE protein was immunohistochemically identified in the crypt cells.	Iron	78-82	homeostatic iron regulator	Homo sapiens	0-3
10834348-7	2000	It was concluded that the soluble transferrin receptor is a more stable indicator of iron status under high training loads since, unlike ferritin, it does not respond to the workload on the preceding day.	Iron	85-89	transferrin receptor	Homo sapiens	34-54
10786005-4	2000	The consumable Fe electrodes generate ferrous ions to cause the reduction of Cr6+ to Cr3+.	Iron	15-17	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	85-88
10692416-2	2000	Cellular iron levels affect binding of IRPs to iron-responsive elements and consequently expression of TfR and ferritin.	Iron	9-13	transferrin receptor	Mus musculus	103-106
10692416-2	2000	Cellular iron levels affect binding of IRPs to iron-responsive elements and consequently expression of TfR and ferritin.	Iron	47-51	transferrin receptor	Mus musculus	103-106
10692416-3	2000	Moreover, NO(*), a redox species of nitric oxide that interacts primarily with iron, can activate IRP-1 RNA binding activity resulting in an increase in TfR mRNA levels.	Iron	79-83	transferrin receptor	Mus musculus	153-156
10719381-2	2000	The description of two mutations in the HFE gene (Cys282Tyr and His63Asp) related to hereditary hemochromatosis provides an opportunity to address the question of the association between iron overload and atherosclerosis.	Iron	187-191	homeostatic iron regulator	Homo sapiens	40-43
10684606-5	2000	Then, CO is condensed with a methyl group and coenzyme A at cluster A, another nickel iron-sulfur cluster in the ACS subunit.	Iron	86-90	acyl-CoA synthetase short chain family member 2	Homo sapiens	113-116
10690503-4	2000	Iron-containing transferrin has a high affinity for the transferrin receptor, which is present on all cells with a requirement for Fe.	Iron	0-4	transferrin receptor	Rattus norvegicus	56-76
10690503-4	2000	Iron-containing transferrin has a high affinity for the transferrin receptor, which is present on all cells with a requirement for Fe.	Iron	131-133	transferrin receptor	Rattus norvegicus	56-76
11232185-3	2000	Moreover, the elucidation of the role of the HFE gene product will provide new insights into the regulation of normal iron absorption and iron metabolism.	Iron	118-122	homeostatic iron regulator	Homo sapiens	45-48
11232185-3	2000	Moreover, the elucidation of the role of the HFE gene product will provide new insights into the regulation of normal iron absorption and iron metabolism.	Iron	138-142	homeostatic iron regulator	Homo sapiens	45-48
10705106-9	2000	This finding suggests that, in the absence of obesity, HFE mutations, through the insulin resistance associated with the increase in iron stores, may contribute to the onset of type 2 diabetes.	Iron	133-137	homeostatic iron regulator	Homo sapiens	55-58
10644325-7	2000	The predictive value of hepatic iron content in patients with alcoholic cirrhosis was confirmed by the Cox model using either a binary coding (p = 0.009; relative risk = 2.27; 95% confidence interval 1.2 to 4.19) or the continuous values (p = 0.002).	Iron	32-36	cytochrome c oxidase subunit 8A	Homo sapiens	103-106
10722800-3	2000	Transferrin receptor mRNA was reduced in myocytes exposed to various concentrations of iron for 3 days and this decline was associated with a 63% decline in iron-response element (IRE) binding of iron regulatory protein-1, indicating that myocytes utilize IRE-dependent mechanisms to modulate gene expression.	Iron	87-91	transferrin receptor	Rattus norvegicus	0-20
10722800-3	2000	Transferrin receptor mRNA was reduced in myocytes exposed to various concentrations of iron for 3 days and this decline was associated with a 63% decline in iron-response element (IRE) binding of iron regulatory protein-1, indicating that myocytes utilize IRE-dependent mechanisms to modulate gene expression.	Iron	87-91	aconitase 1	Rattus norvegicus	196-221
10722800-3	2000	Transferrin receptor mRNA was reduced in myocytes exposed to various concentrations of iron for 3 days and this decline was associated with a 63% decline in iron-response element (IRE) binding of iron regulatory protein-1, indicating that myocytes utilize IRE-dependent mechanisms to modulate gene expression.	Iron	157-161	transferrin receptor	Rattus norvegicus	0-20
10722800-3	2000	Transferrin receptor mRNA was reduced in myocytes exposed to various concentrations of iron for 3 days and this decline was associated with a 63% decline in iron-response element (IRE) binding of iron regulatory protein-1, indicating that myocytes utilize IRE-dependent mechanisms to modulate gene expression.	Iron	157-161	aconitase 1	Rattus norvegicus	196-221
10607838-8	2000	Increased iron deposition was seen in FRDA heart, liver and spleen in a pattern consistent with a mitochondrial location.	Iron	10-14	frataxin	Homo sapiens	38-42
10607838-9	2000	The iron accumulation, mitochondrial respiratory chain and aconitase dysfunction and mitochondrial DNA depletion in FRDA heart samples largely paralleled those in the yeast YFH1 knockout model, suggesting that frataxin may be involved in mitochondrial iron regulation or iron sulphur centre synthesis.	Iron	252-256	frataxin	Homo sapiens	210-218
10810445-10	2000	As with iron and ferritin contents, total iron regulatory protein (IRP-1) binding capacity for mRNA iron responsive element (IRE) and actual IRE/IRP binding in the liver were significantly greater in SWR than C57BL/6J mice.	Iron	8-12	wingless-type MMTV integration site family, member 2	Mus musculus	67-70
10810445-10	2000	As with iron and ferritin contents, total iron regulatory protein (IRP-1) binding capacity for mRNA iron responsive element (IRE) and actual IRE/IRP binding in the liver were significantly greater in SWR than C57BL/6J mice.	Iron	42-46	wingless-type MMTV integration site family, member 2	Mus musculus	67-70
10813095-4	2000	However, the rate of iron uptake from 55Fe-ferric citrate by PI-PLC-treated HeLa cells was comparable or only slightly lower (80-100%) than the rate of iron uptake by untreated cells.	Iron	21-25	phospholipase C beta 1	Homo sapiens	61-67
10813095-4	2000	However, the rate of iron uptake from 55Fe-ferric citrate by PI-PLC-treated HeLa cells was comparable or only slightly lower (80-100%) than the rate of iron uptake by untreated cells.	Iron	152-156	phospholipase C beta 1	Homo sapiens	61-67
12881893-5	2000	The availability of iron from these particles to A549 cells was measured by citrate mobilization in vitro and induction of the iron storage protein ferritin in particle-treated cells.	Iron	20-24	Ferritin 1 heavy chain homologue	Drosophila melanogaster	148-156
12881893-5	2000	The availability of iron from these particles to A549 cells was measured by citrate mobilization in vitro and induction of the iron storage protein ferritin in particle-treated cells.	Iron	127-131	Ferritin 1 heavy chain homologue	Drosophila melanogaster	148-156
10791703-3	2000	From the data summarized in this review, it is hypothesized that Ag-Eb is a member of a subset of the transferrin receptor family and that it functions together with these receptors in the uptake and metabolism of iron, particularly at histo-hematic barriers.	Iron	214-218	transferrin receptor	Homo sapiens	102-122
10756518-1	2000	The iutA gene from marine Vibrio species SD004, which encoded a ferric aerobactin receptor for the uptake of iron(III), was cloned onto a multicopy plasmid, pUC 18, in Escherichia coli.	Iron	109-113	Aerobactin siderophore ferric receptor protein IutA	Escherichia coli	4-8
10600167-5	1999	V(max) values for iron oxidation by P. pastoris Fet3 were obtained similar to human ceruloplasmin and much higher than those reported for Saccharomyces cerevisiae Fet3.	Iron	18-22	ferroxidase FET3	Saccharomyces cerevisiae S288C	48-52
10600167-5	1999	V(max) values for iron oxidation by P. pastoris Fet3 were obtained similar to human ceruloplasmin and much higher than those reported for Saccharomyces cerevisiae Fet3.	Iron	18-22	ferroxidase FET3	Saccharomyces cerevisiae S288C	163-167
10574989-0	1999	Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents.	Iron	33-37	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	6-10
10572108-0	1999	HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells.	Iron	18-22	homeostatic iron regulator	Homo sapiens	0-3
10572108-3	1999	A previously identified interaction of HFE and the transferrin receptor suggests a possible regulatory role of HFE in cellular iron absorption.	Iron	127-131	homeostatic iron regulator	Homo sapiens	39-42
10572108-3	1999	A previously identified interaction of HFE and the transferrin receptor suggests a possible regulatory role of HFE in cellular iron absorption.	Iron	127-131	homeostatic iron regulator	Homo sapiens	111-114
10572108-4	1999	Using an HeLa cell line stably transfected with HFE under the control of a tetracycline-sensitive promoter, we investigated the effect of HFE expression on cellular iron uptake.	Iron	165-169	homeostatic iron regulator	Homo sapiens	138-141
10572108-5	1999	We demonstrate that the overproduction of HFE results in decreased iron uptake from diferric transferrin.	Iron	67-71	homeostatic iron regulator	Homo sapiens	42-45
10572108-6	1999	Moreover, HFE expression activates the key regulators of intracellular iron homeostasis, the iron-regulatory proteins (IRPs), implying that HFE can affect the intracellular "labile iron pool."	Iron	71-75	homeostatic iron regulator	Homo sapiens	10-13
10572108-6	1999	Moreover, HFE expression activates the key regulators of intracellular iron homeostasis, the iron-regulatory proteins (IRPs), implying that HFE can affect the intracellular "labile iron pool."	Iron	71-75	homeostatic iron regulator	Homo sapiens	140-143
10572108-6	1999	Moreover, HFE expression activates the key regulators of intracellular iron homeostasis, the iron-regulatory proteins (IRPs), implying that HFE can affect the intracellular "labile iron pool."	Iron	93-97	homeostatic iron regulator	Homo sapiens	10-13
10572108-6	1999	Moreover, HFE expression activates the key regulators of intracellular iron homeostasis, the iron-regulatory proteins (IRPs), implying that HFE can affect the intracellular "labile iron pool."	Iron	93-97	homeostatic iron regulator	Homo sapiens	140-143
10556042-5	1999	The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.	Iron	50-52	transferrin receptor	Homo sapiens	46-49
10556042-5	1999	The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.	Iron	50-52	transferrin receptor	Homo sapiens	116-119
10556042-5	1999	The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.	Iron	50-52	transferrin receptor	Homo sapiens	116-119
10556042-5	1999	The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.	Iron	50-52	homeostatic iron regulator	Homo sapiens	144-147
10556042-5	1999	The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.	Iron	50-52	homeostatic iron regulator	Homo sapiens	144-147
10556042-5	1999	The results demonstrate that HFE inhibits the TfR:Fe-Tf interaction by binding at or near the Fe-Tf binding site on TfR, and that the Fe-Tf:TfR:HFE ternary complex consists of one Fe-Tf and one HFE bound to a TfR homodimer.	Iron	50-52	transferrin receptor	Homo sapiens	116-119
10551872-2	1999	When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA.	Iron	5-9	transferrin receptor	Mus musculus	185-205
10551872-2	1999	When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA.	Iron	5-9	transferrin receptor	Mus musculus	207-210
10551872-2	1999	When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA.	Iron	68-72	transferrin receptor	Mus musculus	185-205
10551872-2	1999	When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA.	Iron	68-72	transferrin receptor	Mus musculus	207-210
10551872-3	1999	Such binding inhibits translation of ferritin mRNA and stabilizes the mRNA for TfR, whereas the opposite scenario develops when iron in the transit pool is plentiful.	Iron	128-132	transferrin receptor	Mus musculus	79-82
10577506-5	1999	Nramp1 exhibits sequence identity to Nramp2, which regulates intestinal and reticulocyte iron uptake.	Iron	89-93	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	37-43
10518614-6	1999	These results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well-characterized post-transcriptional control of TfR expression to expand the extent of response to iron deficiency.	Iron	99-103	transferrin receptor	Homo sapiens	62-65
10518614-6	1999	These results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well-characterized post-transcriptional control of TfR expression to expand the extent of response to iron deficiency.	Iron	303-307	transferrin receptor	Homo sapiens	62-65
10571078-3	1999	HFE accumulation was accompanied by a large (approximately 10-fold) decrease in H- and L-ferritin levels, by a approximately 3-4-fold increase in transferrin receptor, and a approximately 2-fold increase in iron regulatory protein activity.	Iron	207-211	homeostatic iron regulator	Homo sapiens	0-3
10571078-6	1999	In the HFE-expressing cells the reduction in transferrin-mediated iron incorporation was partially compensated by a approximately 30% increase in non-transferrin iron incorporation from 55Fe-NTA, evident after prolonged, 18 h, incubations.	Iron	66-70	homeostatic iron regulator	Homo sapiens	7-10
10571078-6	1999	In the HFE-expressing cells the reduction in transferrin-mediated iron incorporation was partially compensated by a approximately 30% increase in non-transferrin iron incorporation from 55Fe-NTA, evident after prolonged, 18 h, incubations.	Iron	162-166	homeostatic iron regulator	Homo sapiens	7-10
10571078-7	1999	The findings indicate that HFE binding to transferrin receptor reduces cellular iron availability and regulates the balance between transferrin-mediated and non-transferrin-mediated cellular iron incorporation.	Iron	80-84	homeostatic iron regulator	Homo sapiens	27-30
10571078-7	1999	The findings indicate that HFE binding to transferrin receptor reduces cellular iron availability and regulates the balance between transferrin-mediated and non-transferrin-mediated cellular iron incorporation.	Iron	191-195	homeostatic iron regulator	Homo sapiens	27-30
10491642-2	1999	Studies on serum ceruloplasmin have demonstrated it to be a ferroxidase that is essential for iron transport throughout the body.	Iron	94-98	ceruloplasmin	Rattus norvegicus	17-30
10465173-1	1999	BACKGROUND: Friedreich"s ataxia is caused by a deficiency of frataxin, a protein involved in regulation of mitochondrial iron content.	Iron	121-125	frataxin	Homo sapiens	61-69
10423412-0	1999	Decreased intracellular iron availability suppresses epithelial cell surface plasmin generation.	Iron	24-28	plasminogen	Homo sapiens	77-84
10423412-4	1999	Herein we report that decreased intracellular iron availability markedly suppresses cell-surface plasmin generation by A549 human carcinoma-derived pulmonary epithelial cells.	Iron	46-50	plasminogen	Homo sapiens	97-104
10423412-7	1999	Given these potent in vitro effects on the plasmin/PA system, we speculate that adequate intracellular iron stores are important for successful repair of acute lung injury.	Iron	103-107	plasminogen	Homo sapiens	43-50
10409623-2	1999	Transferrin receptor (TfR) plays a major role in cellular iron uptake through binding and internalizing a carrier protein transferrin (Tf).	Iron	58-62	transferrin receptor	Homo sapiens	0-20
10409623-2	1999	Transferrin receptor (TfR) plays a major role in cellular iron uptake through binding and internalizing a carrier protein transferrin (Tf).	Iron	58-62	transferrin receptor	Homo sapiens	22-25
10406803-6	1999	The ATP-binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs an essential function only in the generation of cytosolic Fe/S proteins by mediating export of Fe/S cluster precursors synthesized by Nfs1p and other mitochondrial proteins.	Iron	152-154	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	43-48
10383365-15	1999	CONCLUSIONS: All 66 patients homozygous for the C282Y mutation of HFE had an elevated hepatic iron concentration, but approximately 15% of these patients did not meet a previous diagnostic criterion for hemochromatosis (hepatic iron index &gt; 1.9 mmol/kg per year).	Iron	94-98	homeostatic iron regulator	Homo sapiens	66-69
10383365-15	1999	CONCLUSIONS: All 66 patients homozygous for the C282Y mutation of HFE had an elevated hepatic iron concentration, but approximately 15% of these patients did not meet a previous diagnostic criterion for hemochromatosis (hepatic iron index &gt; 1.9 mmol/kg per year).	Iron	228-232	homeostatic iron regulator	Homo sapiens	66-69
10383365-16	1999	Determination of HFE genotype is clinically useful in patients with liver disease and suspected iron overload and may lead to identification of otherwise unsuspected C282Y homozygotes.	Iron	96-100	homeostatic iron regulator	Homo sapiens	17-20
10359784-1	1999	In mammalian cells, the level of the iron-storage protein ferritin (Ft) is tightly controlled by the iron-regulatory protein-1 (IRP-1) at the posttranscriptional level.	Iron	37-41	aconitase 1	Homo sapiens	101-126
10359784-1	1999	In mammalian cells, the level of the iron-storage protein ferritin (Ft) is tightly controlled by the iron-regulatory protein-1 (IRP-1) at the posttranscriptional level.	Iron	37-41	aconitase 1	Homo sapiens	128-133
10347228-0	1999	Characterization of the translation-dependent step during iron-regulated decay of transferrin receptor mRNA.	Iron	58-62	transferrin receptor	Homo sapiens	82-102
10347228-1	1999	Iron regulates the stability of the mRNA encoding the transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	54-74
10347228-1	1999	Iron regulates the stability of the mRNA encoding the transferrin receptor (TfR).	Iron	0-4	transferrin receptor	Homo sapiens	76-79
10347228-3	1999	High levels of iron induce degradation of TfR mRNA; the translation inhibitor cycloheximide prevents this.	Iron	15-19	transferrin receptor	Homo sapiens	42-45
10347228-11	1999	These observations suggest that inhibition of translation by cycloheximide interferes with the rate-limiting step of iron-induced TfR mRNA decay in a trans-acting mechanism by blocking IRP inactivation.	Iron	117-121	transferrin receptor	Homo sapiens	130-133
10347228-11	1999	These observations suggest that inhibition of translation by cycloheximide interferes with the rate-limiting step of iron-induced TfR mRNA decay in a trans-acting mechanism by blocking IRP inactivation.	Iron	117-121	Wnt family member 2	Homo sapiens	185-188
10348824-13	1999	The demonstration of IVS3 +1G --&gt; T highlights the possibility of other rare HFE mutations, particularly in C282Y heterozygotes with iron overload.	Iron	136-140	homeostatic iron regulator	Homo sapiens	80-83
10354382-0	1999	Evaluation of iron status of Finnish blood donors using serum transferrin receptor.	Iron	14-18	transferrin receptor	Homo sapiens	62-82
10354382-3	1999	In the present study we have evaluated iron status in blood donors using serum ferritin and transferrin receptor (TfR) concentrations.	Iron	39-43	transferrin receptor	Homo sapiens	114-117
10354382-4	1999	The elevation of serum TfR has been reported to be the most sensitive indicator of depletion of iron stores.	Iron	96-100	transferrin receptor	Homo sapiens	23-26
10329709-1	1999	Human iron regulatory protein-1 (IRP-1) is a bifunctional protein that regulates iron metabolism by binding to mRNAs encoding proteins involved in iron uptake, storage, and utilization.	Iron	6-10	aconitase 1	Homo sapiens	33-38
10329709-1	1999	Human iron regulatory protein-1 (IRP-1) is a bifunctional protein that regulates iron metabolism by binding to mRNAs encoding proteins involved in iron uptake, storage, and utilization.	Iron	81-85	aconitase 1	Homo sapiens	6-31
10329709-1	1999	Human iron regulatory protein-1 (IRP-1) is a bifunctional protein that regulates iron metabolism by binding to mRNAs encoding proteins involved in iron uptake, storage, and utilization.	Iron	81-85	aconitase 1	Homo sapiens	33-38
10329709-2	1999	Intracellular iron accumulation regulates IRP-1 function by promoting the assembly of an iron-sulfur cluster, conferring aconitase activity to IRP-1, and hindering RNA binding.	Iron	14-18	aconitase 1	Homo sapiens	42-47
10329709-2	1999	Intracellular iron accumulation regulates IRP-1 function by promoting the assembly of an iron-sulfur cluster, conferring aconitase activity to IRP-1, and hindering RNA binding.	Iron	14-18	aconitase 1	Homo sapiens	143-148
10329709-2	1999	Intracellular iron accumulation regulates IRP-1 function by promoting the assembly of an iron-sulfur cluster, conferring aconitase activity to IRP-1, and hindering RNA binding.	Iron	89-93	aconitase 1	Homo sapiens	42-47
10318901-0	1999	Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis.	Iron	107-111	transferrin receptor	Homo sapiens	0-20
10318901-0	1999	Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis.	Iron	107-111	homeostatic iron regulator	Homo sapiens	76-79
10318901-2	1999	Recent demonstration of an association between transferrin receptor (TfR) and HFE, a major histocompatibility complex class I-like molecule that has been implicated to play a role in hereditary hemochromatosis, further strengthens the notion that HFE is involved in iron metabolism.	Iron	266-270	transferrin receptor	Homo sapiens	47-67
10318901-2	1999	Recent demonstration of an association between transferrin receptor (TfR) and HFE, a major histocompatibility complex class I-like molecule that has been implicated to play a role in hereditary hemochromatosis, further strengthens the notion that HFE is involved in iron metabolism.	Iron	266-270	transferrin receptor	Homo sapiens	69-72
10318901-2	1999	Recent demonstration of an association between transferrin receptor (TfR) and HFE, a major histocompatibility complex class I-like molecule that has been implicated to play a role in hereditary hemochromatosis, further strengthens the notion that HFE is involved in iron metabolism.	Iron	266-270	homeostatic iron regulator	Homo sapiens	78-81
10318901-2	1999	Recent demonstration of an association between transferrin receptor (TfR) and HFE, a major histocompatibility complex class I-like molecule that has been implicated to play a role in hereditary hemochromatosis, further strengthens the notion that HFE is involved in iron metabolism.	Iron	266-270	homeostatic iron regulator	Homo sapiens	247-250
10318901-5	1999	Moreover, we show that HFE binding reduces the number of functional transferrin binding sites and impairs TfR internalization, thus reducing the uptake of transferrin-bound iron.	Iron	173-177	homeostatic iron regulator	Homo sapiens	23-26
10318901-5	1999	Moreover, we show that HFE binding reduces the number of functional transferrin binding sites and impairs TfR internalization, thus reducing the uptake of transferrin-bound iron.	Iron	173-177	transferrin receptor	Homo sapiens	106-109
10329956-4	1999	Both apotransferrin and Fe-containing Tf produced similar increases in 59Fe efflux, Tf exocytosis, and apolipoprotein A secretion.	Iron	24-26	lipoprotein(a)	Homo sapiens	103-119
10355506-1	1999	BACKGROUND: Two mutations in a newly described gene, HFE, have been proposed as genetic markers for the inherited iron overload disease, genetic haemochromatosis.	Iron	114-118	homeostatic iron regulator	Homo sapiens	53-56
15263355-0	1999	A quantitative in situ Fe K-XAFS study (T &gt; 1270 K) on the oxidation degree of iron in (Mg1-xFex)1-deltaO.	Iron	82-86	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	91-94
10207101-3	1999	Both contain the highly conserved helix-hairpin-helix motif, whereas only one (Ntg2) harbors the characteristic iron-sulfur cluster of the endonuclease III family.	Iron	112-116	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	79-83
10207799-14	1999	These were essentially men with mild iron overload, and might present with distinct iron overload entity(ies) as suggested by the presence in three of an HFE-identical sibling with absence of iron overload.	Iron	84-88	homeostatic iron regulator	Homo sapiens	154-157
10207799-14	1999	These were essentially men with mild iron overload, and might present with distinct iron overload entity(ies) as suggested by the presence in three of an HFE-identical sibling with absence of iron overload.	Iron	84-88	homeostatic iron regulator	Homo sapiens	154-157
10192390-3	1999	Endosomal acidification leads to iron release, and iron is transported out of the endosome through the activity of divalent metal transporter 1 (DMT1, formerly Nramp2), a transmembrane iron transporter that functions only at low pH.	Iron	33-37	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	145-149
10192390-3	1999	Endosomal acidification leads to iron release, and iron is transported out of the endosome through the activity of divalent metal transporter 1 (DMT1, formerly Nramp2), a transmembrane iron transporter that functions only at low pH.	Iron	33-37	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	160-166
10192390-3	1999	Endosomal acidification leads to iron release, and iron is transported out of the endosome through the activity of divalent metal transporter 1 (DMT1, formerly Nramp2), a transmembrane iron transporter that functions only at low pH.	Iron	51-55	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	115-143
10192390-3	1999	Endosomal acidification leads to iron release, and iron is transported out of the endosome through the activity of divalent metal transporter 1 (DMT1, formerly Nramp2), a transmembrane iron transporter that functions only at low pH.	Iron	51-55	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	145-149
10192390-3	1999	Endosomal acidification leads to iron release, and iron is transported out of the endosome through the activity of divalent metal transporter 1 (DMT1, formerly Nramp2), a transmembrane iron transporter that functions only at low pH.	Iron	51-55	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	160-166
10090758-1	1999	Recently, we used 35 GHz pulsed 15N ENDOR spectroscopy to determine the position of the reactive guanidino nitrogen of substrate L-arginine relative to the high-spin ferriheme iron of holo-neuronal nitric oxide synthase (nNOS) [Tierney, D. L., et al.	Iron	176-180	nitric oxide synthase 1	Homo sapiens	184-219
10086785-8	1999	In 19 patients studied at days 0 and 30 of oral iron therapy, the number of peripheral blood CD71+ lymphocytes was shown to be increased from 5.90+/-0.76% to 12.11+/-1.21%.	Iron	48-52	transferrin receptor	Homo sapiens	93-97
9949201-2	1999	Frataxin is a mitochondrial protein, and disruption of a frataxin homolog in yeast results in increased sensitivity to oxidant stress, increased mitochondrial iron and respiration deficiency.	Iron	159-163	frataxin	Homo sapiens	0-8
9949201-4	1999	FRDA fibroblasts were hypersensitive to iron stress and significantly more sensitive to hydrogen peroxide than controls.	Iron	40-44	frataxin	Homo sapiens	0-4
9949201-5	1999	The iron chelator deferoxamine rescued FRDA fibroblasts more than controls from oxidant-induced death, consistent with a role for iron in the differential kinetics of death; however, mean mitochondrial iron content in FRDA fibroblasts was increased by only 40%.	Iron	4-8	frataxin	Homo sapiens	39-43
11601239-0	1999	[The relationship between the expression of transferrin receptors (TfR) on leukemia cells and the cell proliferation and iron metabolism status in childhood acute leukemias].	Iron	121-125	transferrin receptor	Homo sapiens	67-70
11601239-1	1999	OBJECTIVE: To explore the relationship between transferrin receptor (TfR) expression and cell proliferation capacity and iron metabolism status.	Iron	121-125	transferrin receptor	Homo sapiens	47-67
11601239-1	1999	OBJECTIVE: To explore the relationship between transferrin receptor (TfR) expression and cell proliferation capacity and iron metabolism status.	Iron	121-125	transferrin receptor	Homo sapiens	69-72
10067892-4	1999	Here we report the isolation of the FRO2 gene, which is expressed in iron-deficient roots of Arabidopsis.	Iron	69-73	ferric reduction oxidase 2	Arabidopsis thaliana	36-40
10067892-10	1999	The isolation of FRO2 has implications for the generation of crops with improved nutritional quality and increased growth in iron-deficient soils.	Iron	125-129	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
9990067-3	1999	In placenta, the HFE protein colocalizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport.	Iron	159-163	homeostatic iron regulator	Homo sapiens	17-20
9990067-3	1999	In placenta, the HFE protein colocalizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport.	Iron	159-163	transferrin receptor	Homo sapiens	86-106
9990067-3	1999	In placenta, the HFE protein colocalizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport.	Iron	159-163	transferrin receptor	Homo sapiens	108-111
9990067-3	1999	In placenta, the HFE protein colocalizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport.	Iron	159-163	homeostatic iron regulator	Homo sapiens	143-146
9990067-9	1999	We propose that the HFE protein modulates the uptake of transferrin-bound iron from plasma by crypt enterocytes and participates in the mechanism by which the crypt enterocytes sense the level of body iron stores.	Iron	74-78	homeostatic iron regulator	Homo sapiens	20-23
9990067-9	1999	We propose that the HFE protein modulates the uptake of transferrin-bound iron from plasma by crypt enterocytes and participates in the mechanism by which the crypt enterocytes sense the level of body iron stores.	Iron	201-205	homeostatic iron regulator	Homo sapiens	20-23
9990067-10	1999	Impairment of this function caused by HFE gene mutations in HH could provide a paradoxical signal in crypt enterocytes that programs the differentiating enterocytes to absorb more dietary iron when they mature into villus enterocytes.	Iron	188-192	homeostatic iron regulator	Homo sapiens	38-41
9933651-1	1999	Ferritin and transferrin receptor expression is post-transcriptionally regulated by a conserved mRNA sequence termed the iron-responsive element (IRE), to which a transacting protein called the iron-regulatory protein (IRP) is bound.	Iron	121-125	transferrin receptor	Homo sapiens	13-33
9933651-1	1999	Ferritin and transferrin receptor expression is post-transcriptionally regulated by a conserved mRNA sequence termed the iron-responsive element (IRE), to which a transacting protein called the iron-regulatory protein (IRP) is bound.	Iron	121-125	Wnt family member 2	Homo sapiens	194-217
9933651-1	1999	Ferritin and transferrin receptor expression is post-transcriptionally regulated by a conserved mRNA sequence termed the iron-responsive element (IRE), to which a transacting protein called the iron-regulatory protein (IRP) is bound.	Iron	121-125	Wnt family member 2	Homo sapiens	219-222
9933651-13	1999	In aggregate with other investigations involving responses to hypoxia, iron, or nitric oxide, our data indicate that cellular iron metabolic responses are complex and that IRE/IRP-1 interactions vary between cell lines and perhaps between species.	Iron	126-130	aconitase 1	Homo sapiens	176-181
9989689-1	1999	BACKGROUND: The serum transferrin receptor (TfR) concentration in adults is suggested to provide a sensitive measure of iron depletion and together with the serum ferritin concentration to indicate the entire range of iron status, from iron deficiency to iron overload.	Iron	120-124	transferrin receptor	Homo sapiens	22-42
9989689-1	1999	BACKGROUND: The serum transferrin receptor (TfR) concentration in adults is suggested to provide a sensitive measure of iron depletion and together with the serum ferritin concentration to indicate the entire range of iron status, from iron deficiency to iron overload.	Iron	120-124	transferrin receptor	Homo sapiens	44-47
9989689-7	1999	By multiple linear regression analysis, the best predictors of TfR concentration were serum iron (P = 0.004) and log serum ferritin (P &lt; 0.0001), both being inverse correlations (R2 = 0.32).	Iron	92-96	transferrin receptor	Homo sapiens	63-66
9989689-9	1999	CONCLUSIONS: Low serum ferritin and iron concentrations, even within the normal physiologic range, result in high TfR concentrations.	Iron	36-40	transferrin receptor	Homo sapiens	114-117
9989689-10	1999	The lower the iron stores, the stronger the influence of ferritin on TfR.	Iron	14-18	transferrin receptor	Homo sapiens	69-72
9989689-11	1999	A high TfR concentration in children, especially in infants, is a response to physiologically low iron stores.	Iron	98-102	transferrin receptor	Homo sapiens	7-10
9922318-0	1999	Phenotypic expression of HFE mutations: a French study of 1110 unrelated iron-overloaded patients and relatives.	Iron	73-77	homeostatic iron regulator	Homo sapiens	25-28
9922318-7	1999	Family transmission of iron overload linked to HFE was exceptional in non-C282Y +/+ siblings and frequent in C282Y homozygotes.	Iron	23-27	homeostatic iron regulator	Homo sapiens	47-50
9989766-8	1999	These data suggest that the FAC-activated Fe uptake process predominates at physiologically relevant Tf concentrations above the saturation of the Tf receptor (TfR).	Iron	42-44	transferrin receptor	Homo sapiens	147-158
9989766-8	1999	These data suggest that the FAC-activated Fe uptake process predominates at physiologically relevant Tf concentrations above the saturation of the Tf receptor (TfR).	Iron	42-44	transferrin receptor	Homo sapiens	160-163
10730187-7	1999	Proposed mechanisms generally involve higher oxidation states of the iron (Fe = O), analogous to those for P450, and peroxidase systems.	Iron	69-73	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	107-127
9890640-5	1999	The diffusion distance for SSB generation (d) in Fe-deficient cells, measured via inhibition with the *OH scavenger Me2SO using alkaline elution, was 6.5 nm.	Iron	49-51	small RNA binding exonuclease protection factor La	Homo sapiens	27-30
9869610-0	1999	The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C. BACKGROUND &amp; AIMS: Elevated hepatic iron concentration may affect the response to antiviral therapy in chronic hepatitis C. This study explored the contribution of genetic hemochromatosis to iron accumulation in chronic hepatitis C. METHODS: HFE mutations (C282Y and H63D) were assessed in 184 patients with chronic hepatitis C virus and 487 controls.	Iron	141-145	homeostatic iron regulator	Homo sapiens	347-350
9869610-0	1999	The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C. BACKGROUND &amp; AIMS: Elevated hepatic iron concentration may affect the response to antiviral therapy in chronic hepatitis C. This study explored the contribution of genetic hemochromatosis to iron accumulation in chronic hepatitis C. METHODS: HFE mutations (C282Y and H63D) were assessed in 184 patients with chronic hepatitis C virus and 487 controls.	Iron	141-145	homeostatic iron regulator	Homo sapiens	347-350
9869610-5	1999	Biochemical evidence of iron overload was more common in patients with HFE mutations (28 of 47) than in those without (34 of 102; P = 0.0045).	Iron	24-28	homeostatic iron regulator	Homo sapiens	71-74
10440237-1	1999	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA binding proteins that posttranscriptionally regulate the expression of mRNAs coding for proteins involved in the maintenance of iron and energy homeostasis.	Iron	185-189	aconitase 1	Homo sapiens	0-32
10440237-1	1999	Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA binding proteins that posttranscriptionally regulate the expression of mRNAs coding for proteins involved in the maintenance of iron and energy homeostasis.	Iron	185-189	aconitase 1	Homo sapiens	34-38
10440237-6	1999	Here we focus on summarizing the iron-regulated RNA binding activities of the IRPs, as well as the recent findings of IRP regulation by RNS and ROS.	Iron	33-37	Wnt family member 2	Homo sapiens	78-81
10195331-3	1999	We have shown by the electrophoretic mobility shift assay that paraquat, together with low concentrations of chelated iron (Fe++/DETAPAC), induced the activation of transcription factor AP-1 binding activity to DNA.	Iron	118-122	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	186-190
10195331-3	1999	We have shown by the electrophoretic mobility shift assay that paraquat, together with low concentrations of chelated iron (Fe++/DETAPAC), induced the activation of transcription factor AP-1 binding activity to DNA.	Iron	124-128	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	186-190
9915882-0	1999	Reciprocal regulation of HFE and NNamp2 gene expression by iron in human intestinal cells.	Iron	59-63	homeostatic iron regulator	Homo sapiens	25-28
9915882-2	1999	Although the exact functions of these proteins in intestinal iron absorption are unknown, HFE may be required for the down-regulation of iron absorption that occurs with increasing iron status, and Nramp2 may up-regulate iron absorption when iron status is low.	Iron	137-141	homeostatic iron regulator	Homo sapiens	90-93
9915882-2	1999	Although the exact functions of these proteins in intestinal iron absorption are unknown, HFE may be required for the down-regulation of iron absorption that occurs with increasing iron status, and Nramp2 may up-regulate iron absorption when iron status is low.	Iron	137-141	homeostatic iron regulator	Homo sapiens	90-93
9950149-1	1999	Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status.	Iron	127-131	transferrin receptor	Homo sapiens	10-30
9950149-1	1999	Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status.	Iron	127-131	transferrin receptor	Homo sapiens	32-35
9950149-1	1999	Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status.	Iron	175-179	transferrin receptor	Homo sapiens	10-30
9950149-1	1999	Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status.	Iron	175-179	transferrin receptor	Homo sapiens	32-35
9950149-1	1999	Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status.	Iron	175-179	transferrin receptor	Homo sapiens	10-30
9950149-1	1999	Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status.	Iron	175-179	transferrin receptor	Homo sapiens	32-35
9950149-2	1999	In cell culture, iron homeostasis is regulated by coordinate stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory proteins (IRP-1 and -2) which bind to iron-responsive elements (IREs) on the respective mRNAs.	Iron	17-21	transferrin receptor	Homo sapiens	78-81
9950149-2	1999	In cell culture, iron homeostasis is regulated by coordinate stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory proteins (IRP-1 and -2) which bind to iron-responsive elements (IREs) on the respective mRNAs.	Iron	17-21	aconitase 1	Homo sapiens	162-174
9950149-2	1999	In cell culture, iron homeostasis is regulated by coordinate stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory proteins (IRP-1 and -2) which bind to iron-responsive elements (IREs) on the respective mRNAs.	Iron	136-140	aconitase 1	Homo sapiens	162-174
9950149-2	1999	In cell culture, iron homeostasis is regulated by coordinate stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory proteins (IRP-1 and -2) which bind to iron-responsive elements (IREs) on the respective mRNAs.	Iron	136-140	aconitase 1	Homo sapiens	162-174
11498837-7	1999	In both non-induced and induced MEL cells, TfR mRNA levels increased when intracellular iron level decreased; and vice versa.	Iron	88-92	transferrin receptor	Homo sapiens	43-46
11498837-9	1999	Stimulation of erythropoiesis by Epo increased the expression of TfR mRNA, indicating that its expression in erythroid cells was regulated by the level of intracellular iron and the synthesis of heme.	Iron	169-173	transferrin receptor	Homo sapiens	65-68
9837975-0	1998	Characterization of the interaction between Fur and the iron transport promoter of the virulence plasmid in Vibrio anguillarum.	Iron	56-60	ferric iron uptake transcriptional regulator	Vibrio anguillarum 775	44-47
9837975-1	1998	The expression of iron transport genes fatDCBA in Vibrio anguillarum strain 775 is negatively regulated by two iron-responsive repressors, the Fur protein and the antisense RNA, RNAalpha.	Iron	18-22	ferric iron uptake transcriptional regulator	Vibrio anguillarum 775	143-146
9837975-1	1998	The expression of iron transport genes fatDCBA in Vibrio anguillarum strain 775 is negatively regulated by two iron-responsive repressors, the Fur protein and the antisense RNA, RNAalpha.	Iron	111-115	ferric iron uptake transcriptional regulator	Vibrio anguillarum 775	143-146
9837975-2	1998	Here we report the identification of the promoter for the iron transport genes and studied the interaction between the V. anguillarum Fur protein and this promoter.	Iron	58-62	ferric iron uptake transcriptional regulator	Vibrio anguillarum 775	134-137
9837819-4	1998	To determine the effect of Wilson disease missense mutations on ATP7B function, we have developed a yeast complementation assay based on the ability of ATP7B to complement the high-affinity iron-uptake deficiency of the yeast mutant ccc2.	Iron	190-194	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	233-237
9840907-3	1998	Alpha-globin genotype was determined by PCR-based method in 526 adult subjects with reduced mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), normal hemoglobin A2 and F, and normal serum iron.	Iron	206-210	hemoglobin subunit alpha 2	Homo sapiens	0-12
9886303-12	1998	These results raise interesting questions concerning the function of HFE in the control of body iron content and distribution.	Iron	96-100	homeostatic iron regulator	Homo sapiens	69-72
9824612-2	1998	AIMS: To determine the frequency of HFE gene mutations in the general population, their effect on serum iron indexes, and their role in screening for haemochromatosis.	Iron	104-108	homeostatic iron regulator	Homo sapiens	36-39
9824612-9	1998	CONCLUSIONS: HFE mutations are present in 38.4% of the population, affect serum iron indexes, and are important determinants of iron status.	Iron	80-84	homeostatic iron regulator	Homo sapiens	13-16
9824612-9	1998	CONCLUSIONS: HFE mutations are present in 38.4% of the population, affect serum iron indexes, and are important determinants of iron status.	Iron	128-132	homeostatic iron regulator	Homo sapiens	13-16
9868172-3	1998	The targets of IRP action now appear to extend beyond proteins that function in the storage (ferritin) or cellular uptake (transferrin receptor) of iron to include those involved in other aspects of iron metabolism as well as in the tricarboxylic acid cycle.	Iron	148-152	Wnt family member 2	Homo sapiens	15-18
9868172-3	1998	The targets of IRP action now appear to extend beyond proteins that function in the storage (ferritin) or cellular uptake (transferrin receptor) of iron to include those involved in other aspects of iron metabolism as well as in the tricarboxylic acid cycle.	Iron	148-152	transferrin receptor	Homo sapiens	123-143
9868172-3	1998	The targets of IRP action now appear to extend beyond proteins that function in the storage (ferritin) or cellular uptake (transferrin receptor) of iron to include those involved in other aspects of iron metabolism as well as in the tricarboxylic acid cycle.	Iron	199-203	Wnt family member 2	Homo sapiens	15-18
9868172-7	1998	Multiple factors modulate the RNA binding activity of IRP1 and/or IRP2 including iron, nitric oxide, phosphorylation by protein kinase C, oxidative stress and hypoxia/reoxygenation.	Iron	81-85	aconitase 1	Homo sapiens	54-58
9884584-0	1998	Interaction of the hemochromatosis gene product HFE with transferrin receptor modulates cellular iron metabolism.	Iron	97-101	homeostatic iron regulator	Homo sapiens	48-51
9884584-2	1998	Identification of HFE is likely to shed light on one of the major enigmas of mammalian iron homeostasis: How is intestinal iron absorption regulated?	Iron	87-91	homeostatic iron regulator	Homo sapiens	18-21
9884584-2	1998	Identification of HFE is likely to shed light on one of the major enigmas of mammalian iron homeostasis: How is intestinal iron absorption regulated?	Iron	123-127	homeostatic iron regulator	Homo sapiens	18-21
9812986-7	1998	A sulfur transfer role of NIFS in which the enzyme donates sulfur for iron sulfur center formation in nitrogenase was suggested.	Iron	70-74	NFS1 cysteine desulfurase	Homo sapiens	26-30
9808632-2	1998	Positional gene cloning in humans with hereditary hemochromatosis has identified a mutation in a novel major histocompatibility complex (MHC) gene called HFE that is likely to be involved in regulating intestinal iron absorption.	Iron	213-217	homeostatic iron regulator	Homo sapiens	154-157
9808632-6	1998	The observation that the expression of both HFE and Nramp2 mRNAs are reciprocally regulated by cellular iron status in Caco-2 cells, a human intestinal cell line, lends additional credence to the notion that these proteins may work in concert to regulate intestinal iron absorption.	Iron	104-108	homeostatic iron regulator	Homo sapiens	44-47
9808632-6	1998	The observation that the expression of both HFE and Nramp2 mRNAs are reciprocally regulated by cellular iron status in Caco-2 cells, a human intestinal cell line, lends additional credence to the notion that these proteins may work in concert to regulate intestinal iron absorption.	Iron	266-270	homeostatic iron regulator	Homo sapiens	44-47
9782058-1	1998	BACKGROUND: The transferrin receptor (TfR) regulates the cellular uptake of serum iron.	Iron	82-86	transferrin receptor	Homo sapiens	16-36
9782058-1	1998	BACKGROUND: The transferrin receptor (TfR) regulates the cellular uptake of serum iron.	Iron	82-86	transferrin receptor	Homo sapiens	38-41
9801172-0	1998	Drosophila ferritin mRNA: alternative RNA splicing regulates the presence of the iron-responsive element.	Iron	81-85	Ferritin 1 heavy chain homologue	Drosophila melanogaster	11-19
9801172-5	1998	The iron-responsive element was found to bind in vitro specifically to human recombinant iron regulatory protein 1.	Iron	4-8	aconitase 1	Homo sapiens	89-114
9801172-7	1998	Our data provides the first molecular evidence that the presence of iron-responsive element in a ferritin mRNA is regulated by alternative RNA splicing.	Iron	68-72	Ferritin 1 heavy chain homologue	Drosophila melanogaster	97-105
9755249-2	1998	We evaluated the role of hemochromatosis (HFE) gene mutations and other acquired factors in the development of iron overload in these patients.	Iron	111-115	homeostatic iron regulator	Homo sapiens	42-45
9753042-3	1998	We performed PCR-based analysis for the haemochromatosis-related HFE C282Y mutation in an extended family with inherited haemolytic anaemia in which several members exhibited iron overload.	Iron	175-179	homeostatic iron regulator	Homo sapiens	65-68
9700204-1	1998	Frataxin is a mitochondrial protein deficient in Friedreich ataxia (FRDA) and which is associated with abnormal intramitochondrial iron handling.	Iron	131-135	frataxin	Homo sapiens	0-8
9787090-11	1998	Thus, the prolonged, high-level expression of UROS in transduced CEP fibroblasts and lymphoblasts, as well as in transduced K562 erythroid cells, demonstrated that the enzymatic defect in CEP cells could be corrected by retroviral-mediated gene therapy without selection and that the increased intracellular porphyrin intermediates were not toxic to these cells, even when porphyrin production was stimulated by supplemental ALA or iron.	Iron	432-436	uroporphyrinogen III synthase	Homo sapiens	46-50
9735950-3	1998	In Friedreich"s ataxia (FRDA), the most common type of autosomal recessive ataxia, the loss of a mitochondrial protein, frataxin, results in overload of mitochondrial iron and oxidative stress.	Iron	167-171	frataxin	Homo sapiens	120-128
9712864-1	1998	High affinity iron transport in yeast is mediated by two proteins, Fet3p and Ftr1p.	Iron	14-18	ferroxidase FET3	Saccharomyces cerevisiae S288C	67-72
9712864-2	1998	The multicopper oxidase Fet3p is thought to convert extracellular ferrous iron to ferric iron, which then crosses the plasma membrane through the permease Ftr1p.	Iron	66-78	ferroxidase FET3	Saccharomyces cerevisiae S288C	24-29
9712864-8	1998	These observations indicate that the ferroxidase activity of Fet3p is intrinsically required for high affinity iron transport.	Iron	111-115	ferroxidase FET3	Saccharomyces cerevisiae S288C	61-66
9712865-1	1998	The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae is a divalent metal-activated repressor of chromosomal genes that encode proteins responsible for siderophore-mediated iron uptake and also of the gene of certain corynebacteriophages that encodes diphtheria toxin.	Iron	190-194	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
9712865-1	1998	The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae is a divalent metal-activated repressor of chromosomal genes that encode proteins responsible for siderophore-mediated iron uptake and also of the gene of certain corynebacteriophages that encodes diphtheria toxin.	Iron	190-194	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
9694900-14	1998	These observations lead to the speculation that the REXXE motif may play an important role in regulating SFT activity through interaction with intracellular iron and demonstrate that iron transport mediated by SFT is itself an iron-dependent process.	Iron	157-161	ubiquitin conjugating enzyme E2 D1	Homo sapiens	105-108
9694900-14	1998	These observations lead to the speculation that the REXXE motif may play an important role in regulating SFT activity through interaction with intracellular iron and demonstrate that iron transport mediated by SFT is itself an iron-dependent process.	Iron	157-161	ubiquitin conjugating enzyme E2 D1	Homo sapiens	210-213
9694900-14	1998	These observations lead to the speculation that the REXXE motif may play an important role in regulating SFT activity through interaction with intracellular iron and demonstrate that iron transport mediated by SFT is itself an iron-dependent process.	Iron	183-187	ubiquitin conjugating enzyme E2 D1	Homo sapiens	105-108
9694900-14	1998	These observations lead to the speculation that the REXXE motif may play an important role in regulating SFT activity through interaction with intracellular iron and demonstrate that iron transport mediated by SFT is itself an iron-dependent process.	Iron	183-187	ubiquitin conjugating enzyme E2 D1	Homo sapiens	210-213
9694900-14	1998	These observations lead to the speculation that the REXXE motif may play an important role in regulating SFT activity through interaction with intracellular iron and demonstrate that iron transport mediated by SFT is itself an iron-dependent process.	Iron	183-187	ubiquitin conjugating enzyme E2 D1	Homo sapiens	105-108
9694900-14	1998	These observations lead to the speculation that the REXXE motif may play an important role in regulating SFT activity through interaction with intracellular iron and demonstrate that iron transport mediated by SFT is itself an iron-dependent process.	Iron	183-187	ubiquitin conjugating enzyme E2 D1	Homo sapiens	210-213
9714452-8	1998	Dysfunction of Tf or TfR would possibly lead to iron irregulation in the brain and consequently cause damage to neuronal functions.	Iron	48-52	transferrin receptor	Homo sapiens	21-24
9669792-8	1998	Tests for HFE mutations may play a role in confirming the diagnosis of hereditary hemochromatosis in persons with elevated serum iron measures, but even this use is limited by uncertainty about genotype-phenotype correlations.	Iron	129-133	homeostatic iron regulator	Homo sapiens	10-13
9667602-2	1998	Studies of frataxin homologues in lower eukaryotes suggest that mitochondrial iron accumulation may underlie the pathophysiology of FRDA.	Iron	78-82	frataxin	Homo sapiens	11-19
9667602-2	1998	Studies of frataxin homologues in lower eukaryotes suggest that mitochondrial iron accumulation may underlie the pathophysiology of FRDA.	Iron	78-82	frataxin	Homo sapiens	132-136
9667602-3	1998	To evaluate the possible role of iron-chelation therapy for FRDA, we measured serum iron and ferritin concentrations in 10 FRDA patients.	Iron	33-37	frataxin	Homo sapiens	60-64
9667602-4	1998	The measurements were within normal limits, suggesting that iron-chelation therapy for FRDA may be problematic.	Iron	60-64	frataxin	Homo sapiens	87-91
9639675-6	1998	Stimulation of iron uptake by neuroleptics is probably related to their property of calmodulin antagonism, since calmidazolium also stimulated synaptosomal iron uptake from both donors.	Iron	15-19	calmodulin 1	Rattus norvegicus	84-94
9639675-9	1998	The results are in agreement with the iron uptake magnitude observed with the different drugs for the two iron donors used and the reported Ki values of neuroleptic drugs for calmodulin antagonism evaluated by the inhibition of 3",5"-monophosphate phosphodiesterase activity.	Iron	38-42	calmodulin 1	Rattus norvegicus	175-185
9845473-0	1998	Failure to respond to interferon-alpha 2a therapy is associated with increased hepatic iron levels in patients with chronic hepatitis C. Recent reports suggest the hepatic iron concentration (HIC) may influence the activity of hepatitis and the response to interferon (IFN) therapy in patients with chronic hepatitis C (CH-C).	Iron	87-91	interferon alpha 2	Homo sapiens	22-41
9845473-0	1998	Failure to respond to interferon-alpha 2a therapy is associated with increased hepatic iron levels in patients with chronic hepatitis C. Recent reports suggest the hepatic iron concentration (HIC) may influence the activity of hepatitis and the response to interferon (IFN) therapy in patients with chronic hepatitis C (CH-C).	Iron	172-176	interferon alpha 2	Homo sapiens	22-41
9727731-10	1998	HFE mutations also appear to increase the likelihood of iron overload in inherited anemias and to promote the clinical manifestations of porphyria cutanea tarda.	Iron	56-60	homeostatic iron regulator	Homo sapiens	0-3
9703002-1	1998	PURPOSE: The goal of this study was to determine if the postnatal changes in plasma transferrin receptor (TfR) levels in healthy infants were associated with changes in erythropoiesis or iron status.	Iron	187-191	transferrin receptor	Homo sapiens	84-104
9703002-1	1998	PURPOSE: The goal of this study was to determine if the postnatal changes in plasma transferrin receptor (TfR) levels in healthy infants were associated with changes in erythropoiesis or iron status.	Iron	187-191	transferrin receptor	Homo sapiens	106-109
9755460-2	1998	Although NO reversibly interacts with the heme-iron of P450, the pathophysiological role of this interaction remains to be elucidated.	Iron	47-51	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	55-59
15012226-4	1998	These have led to the discovery of NifS-homologues and cysteine desulfhydrase for iron-sulfur center assembly, six loci (CCS1-CCS5, ccsA) for c-type cytochrome assembly, four loci for cytochrome b6 assembly (CCB1-CCB4), the CtpA protease, which is involved in pre-D1 processing, and the PCY2 locus, which is involved in holoplastocyanin accumulation.	Iron	82-86	cofactor assembly of complex C	Arabidopsis thaliana	208-212
9603151-2	1998	We now report our in vivo observations, which show an increase in the expression of PDGF-R alpha mRNA, but not PDGF-beta receptor mRNA, in asbestos-exposed rat lungs when compared with RNA from air-exposed (sham) and iron-exposed lungs.	Iron	217-221	platelet derived growth factor receptor alpha	Rattus norvegicus	84-96
9673397-5	1998	The addition of exogenous iron as transferrin-iron to the culture medium reversed the cytotoxicity of gallium nitrate and PIH in a dose-dependent manner but had only minor effects on the cytotoxicity of Ga-PIH.	Iron	26-30	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	122-125
9673397-5	1998	The addition of exogenous iron as transferrin-iron to the culture medium reversed the cytotoxicity of gallium nitrate and PIH in a dose-dependent manner but had only minor effects on the cytotoxicity of Ga-PIH.	Iron	26-30	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	206-209
9673397-5	1998	The addition of exogenous iron as transferrin-iron to the culture medium reversed the cytotoxicity of gallium nitrate and PIH in a dose-dependent manner but had only minor effects on the cytotoxicity of Ga-PIH.	Iron	46-50	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	122-125
9576481-6	1998	Aconitase is thus converted into an iron regulatory protein-1 (IRP-1) that causes iron uptake to prevail over sequestration, forming a pool of free iron that is used for metabolic functions.	Iron	36-40	aconitase 1	Homo sapiens	63-68
9576481-6	1998	Aconitase is thus converted into an iron regulatory protein-1 (IRP-1) that causes iron uptake to prevail over sequestration, forming a pool of free iron that is used for metabolic functions.	Iron	82-86	aconitase 1	Homo sapiens	36-61
9576481-6	1998	Aconitase is thus converted into an iron regulatory protein-1 (IRP-1) that causes iron uptake to prevail over sequestration, forming a pool of free iron that is used for metabolic functions.	Iron	82-86	aconitase 1	Homo sapiens	63-68
9576481-7	1998	Conversely, cluster reassembly converts IRP-1 back to aconitase, providing a regulatory mechanism to decrease free iron when it exceeds metabolic requirements.	Iron	115-119	aconitase 1	Homo sapiens	40-45
9658731-12	1998	The analysis of HFE gene mutations (C282Y and H63D) is a simple and strong tool in the diagnostic work out of iron overload conditions.	Iron	110-114	homeostatic iron regulator	Homo sapiens	16-19
9658732-9	1998	It is clear by the analysis of its structure that HFE protein is not an iron transporter itself, but has a regulatory role in iron metabolism.	Iron	72-76	homeostatic iron regulator	Homo sapiens	50-53
9658732-14	1998	The recent association of HFE gene with transferrin receptor (TfR) in trophoblast cells opens new possibilities on its role in cellular iron uptake.	Iron	136-140	homeostatic iron regulator	Homo sapiens	26-29
9658732-14	1998	The recent association of HFE gene with transferrin receptor (TfR) in trophoblast cells opens new possibilities on its role in cellular iron uptake.	Iron	136-140	transferrin receptor	Homo sapiens	40-60
9658732-14	1998	The recent association of HFE gene with transferrin receptor (TfR) in trophoblast cells opens new possibilities on its role in cellular iron uptake.	Iron	136-140	transferrin receptor	Homo sapiens	62-65
9624883-1	1998	Serum transferrin receptors (TfR) are a sensitive index of tissue iron availability, increasing progressively in response to functional iron deficiency.	Iron	66-70	transferrin receptor	Homo sapiens	29-32
9624883-3	1998	Therefore, serum TfR measurement is particularly promising for evaluation of iron status when iron deficiency is simultaneously present with overt or subclinical infection or inflammation--a scenario often seen in patients seeking medical care, in elderly persons, and in persons living in developing countries.	Iron	77-81	transferrin receptor	Homo sapiens	17-20
9624883-5	1998	With the exception of conditions associated with markedly enhanced erythropoiesis which can increase TfR independently (e.g., megaloblastic anemia, thalassemia), serum TfR determination is a specific test of iron status.	Iron	208-212	transferrin receptor	Homo sapiens	168-171
9624883-7	1998	These sensitivity, specificity, and reliability characteristics of serum TfR measurement enable it to enhance confidence in iron status assessment in complex situations with the standard repertoire of laboratory tests.	Iron	124-128	transferrin receptor	Homo sapiens	73-76
9545264-1	1998	Iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	0-4	aconitase 1	Homo sapiens	26-30
9545264-1	1998	Iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins that control iron metabolism in mammalian cells.	Iron	95-99	aconitase 1	Homo sapiens	26-30
9545264-2	1998	Both IRPs bind to specific sequences called iron-responsive elements (IREs) located in the 3" or 5" untranslated regions of several mRNAs, in particular mRNA encoding ferritin and transferrin receptor.	Iron	44-48	transferrin receptor	Mus musculus	180-200
9531620-11	1998	The higher iron absorption capacity in the beta2m-/- mice may involve the initial step of ferric mucosal uptake and the subsequent step of mucosal transfer of iron to the plasma.	Iron	159-163	beta-2 microglobulin	Mus musculus	43-49
9546397-2	1998	HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism.	Iron	69-73	homeostatic iron regulator	Homo sapiens	0-3
9546397-2	1998	HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism.	Iron	69-73	homeostatic iron regulator	Homo sapiens	106-109
9546397-2	1998	HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism.	Iron	113-117	homeostatic iron regulator	Homo sapiens	0-3
9546397-2	1998	HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism.	Iron	113-117	transferrin receptor	Homo sapiens	35-38
9546397-2	1998	HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism.	Iron	113-117	homeostatic iron regulator	Homo sapiens	106-109
9555030-2	1998	We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis.	Iron	50-54	aconitase 1	Homo sapiens	146-151
9555030-2	1998	We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis.	Iron	107-111	aconitase 1	Homo sapiens	146-151
9555030-2	1998	We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis.	Iron	107-111	aconitase 1	Homo sapiens	146-151
9506995-0	1998	Influence of copper depletion on iron uptake mediated by SFT, a stimulator of Fe transport.	Iron	33-37	ubiquitin conjugating enzyme E2 D1	Homo sapiens	64-90
9506995-1	1998	We recently identified a novel factor involved in cellular iron assimilation called SFT or Stimulator of Fe Transport (Gutierrez, J.	Iron	59-63	ubiquitin conjugating enzyme E2 D1	Homo sapiens	91-117
10683982-1	1998	The oscillopolarographic method (proposed by Ding Jianwen)for the simulltaneous determination of copper, iron and zinc in hair was further studied and applied to the investigation of copper, iron, zinc content in hair samples from 46 mentally retarded children and 49 healthy children.	Iron	105-109	ring finger protein 2	Homo sapiens	45-49
9482759-1	1998	Iron regulatory protein 1 (IRP1) and IRP2 are cytoplasmic RNA binding proteins that are central regulators of mammalian iron homeostasis.	Iron	120-124	aconitase 1	Homo sapiens	0-25
9482759-1	1998	Iron regulatory protein 1 (IRP1) and IRP2 are cytoplasmic RNA binding proteins that are central regulators of mammalian iron homeostasis.	Iron	120-124	aconitase 1	Homo sapiens	27-31
9482759-3	1998	Rats were fed a diet containing 2 or 34 mg iron/kg diet for 1-28 d. Liver IRP activity increased rapidly in rats fed the iron-deficient diet with IRP1 stimulated by d 1 and IRP2 by d 2.	Iron	43-47	caspase 3	Rattus norvegicus	74-77
9482759-3	1998	Rats were fed a diet containing 2 or 34 mg iron/kg diet for 1-28 d. Liver IRP activity increased rapidly in rats fed the iron-deficient diet with IRP1 stimulated by d 1 and IRP2 by d 2.	Iron	43-47	aconitase 1	Rattus norvegicus	146-150
9482759-3	1998	Rats were fed a diet containing 2 or 34 mg iron/kg diet for 1-28 d. Liver IRP activity increased rapidly in rats fed the iron-deficient diet with IRP1 stimulated by d 1 and IRP2 by d 2.	Iron	121-125	caspase 3	Rattus norvegicus	74-77
9482759-3	1998	Rats were fed a diet containing 2 or 34 mg iron/kg diet for 1-28 d. Liver IRP activity increased rapidly in rats fed the iron-deficient diet with IRP1 stimulated by d 1 and IRP2 by d 2.	Iron	121-125	aconitase 1	Rattus norvegicus	146-150
9465039-12	1998	These results establish a molecular link between HFE and a key protein involved in iron transport, the TfR, and raise the possibility that alterations in this regulatory mechanism may play a role in the pathogenesis of hereditary hemochromatosis.	Iron	83-87	homeostatic iron regulator	Homo sapiens	49-52
9465039-12	1998	These results establish a molecular link between HFE and a key protein involved in iron transport, the TfR, and raise the possibility that alterations in this regulatory mechanism may play a role in the pathogenesis of hereditary hemochromatosis.	Iron	83-87	transferrin receptor	Homo sapiens	103-106
9550555-1	1998	The concentration of soluble transferrin receptor (sTfR) in serum is reported to be useful in the diagnosis of iron deficiency, especially for patients with concurrent chronic disease, where routine tests of iron status are compromised by the inflammatory condition.	Iron	111-115	transferrin receptor	Homo sapiens	29-49
9506827-3	1998	Photofrin significantly increased spleen cell expression of the receptor (CD71) for the iron transport protein transferrin by 72 h post-injection but did not affect levels of a receptor (CD25) for the T-cell growth factor interleukin-2 (IL-2) or spleen cell responsiveness to rIL-2.	Iron	88-92	transferrin receptor	Mus musculus	74-78
9771919-2	1998	During inflammation, modification of IRP activity may affect iron availability, free radical generation and cytokine gene response in inflammatory cells.	Iron	61-65	Wnt family member 2	Homo sapiens	37-40
9393673-0	1997	Dinitrosyl-dithiol-iron complexes, nitric oxide (NO) carriers in vivo, as potent inhibitors of human glutathione reductase and glutathione-S-transferase.	Iron	19-23	glutathione-disulfide reductase	Homo sapiens	101-122
9448235-6	1997	Infusion of TF caused a dose-dependent increase in the concentration of TF and an increase in the unsaturated iron-binding capacity.	Iron	110-114	serotransferrin	Oryctolagus cuniculus	12-14
9448235-10	1997	We propose that supplementation of iron-free TF decreases iron-catalyzed redox reactions and may decrease hyperoxic lung injury in the premature.	Iron	35-39	serotransferrin	Oryctolagus cuniculus	45-47
9448235-10	1997	We propose that supplementation of iron-free TF decreases iron-catalyzed redox reactions and may decrease hyperoxic lung injury in the premature.	Iron	58-62	serotransferrin	Oryctolagus cuniculus	45-47
9440321-2	1997	In addition, the iron chelator 1,2-diethyl-3-hydroxypyridin-4-one (CP94) was used.	Iron	17-21	beaded filament structural protein 1	Homo sapiens	67-71
9317037-0	1997	Identification and characterization of three new promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron.	Iron	165-169	MarR family transcriptional regulator	Corynebacterium diphtheriae	127-153
9317037-1	1997	DtxR is a dimeric, sequence-specific, DNA-binding protein that functions as an iron-dependent, negative global regulator in Corynebacterium diphtheriae.	Iron	79-83	MarR family transcriptional regulator	Corynebacterium diphtheriae	0-4
9317037-2	1997	Under high-iron conditions, DtxR represses the synthesis of diphtheria toxin, corynebacterial siderophore, and other components of the high-affinity iron uptake system.	Iron	11-15	MarR family transcriptional regulator	Corynebacterium diphtheriae	28-32
9317037-2	1997	Under high-iron conditions, DtxR represses the synthesis of diphtheria toxin, corynebacterial siderophore, and other components of the high-affinity iron uptake system.	Iron	149-153	MarR family transcriptional regulator	Corynebacterium diphtheriae	28-32
9326946-6	1997	The function of the protein is unknown, but an increased iron content has been reported in hearts of FRDA patients and in mitochondria of yeast strains carrying a deleted frataxin gene counterpart (YFH1), suggesting that frataxin plays a major role in regulating mitochondrial iron transport.	Iron	277-281	frataxin	Homo sapiens	221-229
9326491-14	1997	These results provide indications of the mechanism by which IRP-1 stabilizes the transferrin receptor mRNA under iron depletion conditions.	Iron	113-117	aconitase 1	Homo sapiens	60-65
9278258-0	1997	Inhibitory mechanism of lead on transferrin-bound iron uptake by rabbit reticulocytes: a fractal analysis.	Iron	50-54	serotransferrin	Oryctolagus cuniculus	32-43
9278258-1	1997	Experimental data of transferrin and transferrin-bound iron uptake by rabbit reticulocytes in the presence or absence of extracellular lead is analyzed by means of a fractal model.	Iron	55-59	serotransferrin	Oryctolagus cuniculus	37-48
9278258-2	1997	A highly significant correlation of fractal dimension (Df) of intracellular transferrin or transferrin-bound iron uptake with varying extracellular concentrations of lead (0 approximately 25 umol/L) was observed (Transferrin: r = 0.897, p = 0.015; transferrin-bound iron: r = 0.947, p = 0.004).	Iron	109-113	serotransferrin	Oryctolagus cuniculus	91-102
9278258-2	1997	A highly significant correlation of fractal dimension (Df) of intracellular transferrin or transferrin-bound iron uptake with varying extracellular concentrations of lead (0 approximately 25 umol/L) was observed (Transferrin: r = 0.897, p = 0.015; transferrin-bound iron: r = 0.947, p = 0.004).	Iron	109-113	serotransferrin	Oryctolagus cuniculus	213-224
9278258-2	1997	A highly significant correlation of fractal dimension (Df) of intracellular transferrin or transferrin-bound iron uptake with varying extracellular concentrations of lead (0 approximately 25 umol/L) was observed (Transferrin: r = 0.897, p = 0.015; transferrin-bound iron: r = 0.947, p = 0.004).	Iron	109-113	serotransferrin	Oryctolagus cuniculus	91-102
9278258-2	1997	A highly significant correlation of fractal dimension (Df) of intracellular transferrin or transferrin-bound iron uptake with varying extracellular concentrations of lead (0 approximately 25 umol/L) was observed (Transferrin: r = 0.897, p = 0.015; transferrin-bound iron: r = 0.947, p = 0.004).	Iron	266-270	serotransferrin	Oryctolagus cuniculus	76-87
9278258-2	1997	A highly significant correlation of fractal dimension (Df) of intracellular transferrin or transferrin-bound iron uptake with varying extracellular concentrations of lead (0 approximately 25 umol/L) was observed (Transferrin: r = 0.897, p = 0.015; transferrin-bound iron: r = 0.947, p = 0.004).	Iron	266-270	serotransferrin	Oryctolagus cuniculus	213-224
9241278-7	1997	If Nramp2 is mk, as the cumulative evidence suggests, our findings have broad implications for the understanding of iron transport and resistance to intracellular pathogens.	Iron	116-120	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	3-9
9244414-3	1997	We report herein that the in vitro T cell proliferation and NK activity in PSC products of breast cancer patients are significantly increased following the removal of CD14+ monocytes (33 +/- 2% of the PSC product) by carbonyl iron magnetic cell isolation (CI).	Iron	226-230	CD14 molecule	Homo sapiens	167-171
9180083-0	1997	Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin.	Iron	28-32	frataxin	Homo sapiens	78-86
9177409-4	1997	This exon skipping alters the translational reading frame of exon 8 and introduces a premature stop codon (TAA) at amino acid position 410 proximal to the heme iron-binding site essential for the enzymatic activity of CYP17.	Iron	160-164	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	218-223
9169016-1	1997	We have reported previously that the heavy chain of ferritin is required for iron incorporation by ceruloplasmin (J.-H. Guo, M. Abedi, and S. D. Aust (1996) Arch.	Iron	77-81	ceruloplasmin	Rattus norvegicus	99-112
9169016-5	1997	The purpose of this study was to determine how many heavy chains were required for ceruloplasmin to interact with ferritin such that iron loading occurred.	Iron	133-137	ceruloplasmin	Rattus norvegicus	83-96
9169016-9	1997	The maximal extent of iron loading was observed using 1 mol of rat ceruloplasmin per mole of H chain in the two heteropolymers.	Iron	22-26	ceruloplasmin	Rattus norvegicus	67-80
9169016-10	1997	The extent of iron incorporation decreased with additional ceruloplasmin.	Iron	14-18	ceruloplasmin	Rattus norvegicus	59-72
9169016-11	1997	Iron incorporation into rat liver ferritin, found to contain 10 H chains, increased as the molar ratio of ceruloplasmin to ferritin increased to 4:1 and remained the same up to 8:1.	Iron	0-4	ceruloplasmin	Rattus norvegicus	106-119
9169016-13	1997	Therefore, we propose that the optimal molar ratio of ceruloplasmin to ferritin depends upon the numbers of H chain making up the ferritin molecule for the maximal incorporation of iron into ferritin.	Iron	181-185	ceruloplasmin	Rattus norvegicus	54-67
9191359-0	1997	Iron in synovial fluid: removal by lactoferrin, and relationship to iron regulatory protein (IRP) activity.	Iron	0-4	Wnt family member 2	Homo sapiens	68-91
9191359-0	1997	Iron in synovial fluid: removal by lactoferrin, and relationship to iron regulatory protein (IRP) activity.	Iron	0-4	Wnt family member 2	Homo sapiens	93-96
9109411-1	1997	A recombinant truncated form (delta1-102/delta428-452) of the non-heme iron-dependent metalloenzyme human phenylalanine hydroxylase (hPAH, phenylalanine 4-monooxygenase; EC 1.14.16.1) was expressed in E. coli, purified to homogeneity as a homodimer (70 kDa) and crystallized using the hanging drop vapour diffusion method.	Iron	71-75	phenylalanine hydroxylase	Homo sapiens	106-131
9109411-1	1997	A recombinant truncated form (delta1-102/delta428-452) of the non-heme iron-dependent metalloenzyme human phenylalanine hydroxylase (hPAH, phenylalanine 4-monooxygenase; EC 1.14.16.1) was expressed in E. coli, purified to homogeneity as a homodimer (70 kDa) and crystallized using the hanging drop vapour diffusion method.	Iron	71-75	phenylalanine hydroxylase	Homo sapiens	139-168
9116301-3	1997	In RE cells of GH subjects, we examined the activity of iron regulatory protein (IRP), a reliable indicator of the elusive regulatory labile iron pool, which modulates cellular iron homeostasis through control of ferritin (Ft) and transferrin receptor gene expression.	Iron	56-60	Wnt family member 2	Homo sapiens	81-84
9116301-3	1997	In RE cells of GH subjects, we examined the activity of iron regulatory protein (IRP), a reliable indicator of the elusive regulatory labile iron pool, which modulates cellular iron homeostasis through control of ferritin (Ft) and transferrin receptor gene expression.	Iron	141-145	Wnt family member 2	Homo sapiens	81-84
9116301-4	1997	RNA-bandshift assays showed a significant increase in IRP activity in monocytes from 16 patients with untreated GH compared with 28 control subjects (1.5-fold) and five patients with secondary hemochromatosis (SH) with similar iron burden (fourfold).	Iron	227-231	Wnt family member 2	Homo sapiens	54-57
9116301-7	1997	IRP activity was still upregulated in vitro in monocyte-derived macrophages of GH subjects but, following manipulations of iron levels, was modulated normally.	Iron	123-127	Wnt family member 2	Homo sapiens	0-3
9116301-8	1997	Therefore, the sustained activity of monocyte IRP found in vivo in monocytes of GH patients is not due to an inherent defect of its control, but is rather the expression of a critical abnormality of iron metabolism, eg, a paradoxical contraction of the regulatory iron pool.	Iron	199-203	Wnt family member 2	Homo sapiens	46-49
9116301-8	1997	Therefore, the sustained activity of monocyte IRP found in vivo in monocytes of GH patients is not due to an inherent defect of its control, but is rather the expression of a critical abnormality of iron metabolism, eg, a paradoxical contraction of the regulatory iron pool.	Iron	264-268	Wnt family member 2	Homo sapiens	46-49
9116301-9	1997	By preventing Ft mRNA translation, high IRP activity in monocytes may represent a molecular mechanism contributing to the inadequate Ft accumulation and insufficient RE iron storage in GH.	Iron	169-173	Wnt family member 2	Homo sapiens	40-43
9116047-1	1997	Heme oxygenase-2 (HO-2) is constitutively expressed in mammalian tissues; together with HO-1 (HSP32) it catalyzes the cleavage of heme to produce biliverdin IX alpha, CO and Fe.	Iron	174-176	heme oxygenase 2	Homo sapiens	0-16
9116047-1	1997	Heme oxygenase-2 (HO-2) is constitutively expressed in mammalian tissues; together with HO-1 (HSP32) it catalyzes the cleavage of heme to produce biliverdin IX alpha, CO and Fe.	Iron	174-176	heme oxygenase 2	Homo sapiens	18-22
9110146-12	1997	in the presence of iron ions play a major role in HIV-1 Tat enhancement of TNF-induced NF-kappa B activation and that iron chelation may protect Jurkat T cells, at least in part, against oxidative stress induced by Tat.	Iron	19-23	tyrosine aminotransferase	Homo sapiens	215-218
9110146-12	1997	in the presence of iron ions play a major role in HIV-1 Tat enhancement of TNF-induced NF-kappa B activation and that iron chelation may protect Jurkat T cells, at least in part, against oxidative stress induced by Tat.	Iron	118-122	tyrosine aminotransferase	Homo sapiens	215-218
9029643-1	1997	The transferrin receptor in serum provides a useful measure of tissue iron deficiency and the rate of erythropoiesis, whereas serum ferritin reflects the amount of storage iron in normal subjects.	Iron	70-74	transferrin receptor	Homo sapiens	4-24
9002972-0	1997	Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells.	Iron	23-27	transferrin receptor	Homo sapiens	116-136
9002972-5	1997	Activation of IRP-1 by Epo is associated with a marked increase in transferrin receptor (trf-rec) mRNA levels in K562 and MEL, enhanced cell surface expression of trf-recs, and increased uptake of iron into cells.	Iron	197-201	aconitase 1	Homo sapiens	14-19
9002972-8	1997	Our results provide evidence for a direct functional connection between Epo biology and iron metabolism by which Epo increases iron uptake into erythroid progenitor cells via posttranscriptional induction of trf-rec expression.	Iron	88-92	transferrin receptor	Homo sapiens	208-215
9002972-8	1997	Our results provide evidence for a direct functional connection between Epo biology and iron metabolism by which Epo increases iron uptake into erythroid progenitor cells via posttranscriptional induction of trf-rec expression.	Iron	127-131	transferrin receptor	Homo sapiens	208-215
9215812-8	1997	MnSOD protects against TNF by decreasing O2- attack on [4Fe-4S] clusters and thus lowering free iron.	Iron	96-100	superoxide dismutase 2	Homo sapiens	0-5
9046019-4	1997	Using a reconstituted system comprised of purified NADPH-P450 reductase, P450 and isolated microsomal lipid or pure L-alpha-phosphatidylcholine diarachidoyl, a mechanism has been proposed for the iron-independent microsomal lipid peroxidation and its prevention by ascorbic acid.	Iron	196-200	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	57-61
9046019-4	1997	Using a reconstituted system comprised of purified NADPH-P450 reductase, P450 and isolated microsomal lipid or pure L-alpha-phosphatidylcholine diarachidoyl, a mechanism has been proposed for the iron-independent microsomal lipid peroxidation and its prevention by ascorbic acid.	Iron	196-200	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-77
8994263-2	1997	IRP-1 is the cytoplasmic isoform of the enzyme aconitase, and, depending on iron status, may switch between enzymatic and RNA-binding activities.	Iron	76-80	aconitase 1	Homo sapiens	0-5
8994263-3	1997	IRP-1 and IRP-2 are trans-acting regulators of mRNAs involved in iron uptake, storage and utilisation.	Iron	65-69	aconitase 1	Homo sapiens	0-5
8996512-3	1997	We tested the hypothesis that a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist GPI 3000 (GPI) ameliorates metabolic injury and that the effectiveness of the iron-chelator and antioxidant deferoxamine (DFO) is augmented by combined therapy with GPI after incomplete global cerebral ischemia.	Iron	176-180	glucose-6-phosphate isomerase	Canis lupus familiaris	98-101
8996512-3	1997	We tested the hypothesis that a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist GPI 3000 (GPI) ameliorates metabolic injury and that the effectiveness of the iron-chelator and antioxidant deferoxamine (DFO) is augmented by combined therapy with GPI after incomplete global cerebral ischemia.	Iron	176-180	glucose-6-phosphate isomerase	Canis lupus familiaris	108-111
8996512-3	1997	We tested the hypothesis that a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist GPI 3000 (GPI) ameliorates metabolic injury and that the effectiveness of the iron-chelator and antioxidant deferoxamine (DFO) is augmented by combined therapy with GPI after incomplete global cerebral ischemia.	Iron	176-180	glucose-6-phosphate isomerase	Canis lupus familiaris	108-111
8915458-2	1996	These processes require iron for the synthesis of iron-dependent proteins, the supply of which is mediated through the transferrin receptor.	Iron	24-28	transferrin receptor	Rattus norvegicus	119-139
8915458-2	1996	These processes require iron for the synthesis of iron-dependent proteins, the supply of which is mediated through the transferrin receptor.	Iron	50-54	transferrin receptor	Rattus norvegicus	119-139
8902535-8	1996	In mammalian cells oxidants are able to convert cytosolic aconitase into active IRE-BP, which increases the "free" iron concentration intracellularly both by decreasing the biosynthesis of ferritin and increasing biosynthesis of transferrin receptors.	Iron	115-119	aconitase 1	Homo sapiens	80-86
8920884-0	1996	Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.	Iron	10-14	beta-2 microglobulin	Mus musculus	30-50
8920884-1	1996	Previously, hepatic iron overload resembling that in hereditary hemachromatosis (HH) has been found in beta 2-microglobulin knockout (beta 2m-/-) mice.	Iron	20-24	beta-2 microglobulin	Mus musculus	103-123
8920884-1	1996	Previously, hepatic iron overload resembling that in hereditary hemachromatosis (HH) has been found in beta 2-microglobulin knockout (beta 2m-/-) mice.	Iron	20-24	beta-2 microglobulin	Mus musculus	134-145
8920884-2	1996	We have now characterized iron metabolism in beta 2m-/- mice.	Iron	26-30	beta-2 microglobulin	Mus musculus	45-55
8920884-7	1996	We conclude that (a) iron metabolism is defective in the gut mucosa as well as the liver of beta 2m-/- mice; and (b) a beta 2m-dependent gene product is involved in iron homeostasis.	Iron	21-25	beta-2 microglobulin	Mus musculus	92-102
8710843-3	1996	Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs).	Iron	38-42	aconitase 1	Homo sapiens	65-70
8710843-3	1996	Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs).	Iron	38-42	Wnt family member 2	Homo sapiens	65-68
8710843-3	1996	Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs).	Iron	114-118	aconitase 1	Homo sapiens	38-63
8710843-3	1996	Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs).	Iron	114-118	aconitase 1	Homo sapiens	65-70
8710843-3	1996	Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs).	Iron	114-118	Wnt family member 2	Homo sapiens	65-68
8710843-6	1996	In addition to providing insights into the regulation of iron metabolism and its connections with other cellular pathways, the IRE/IRP system has emerged as a prime example for the understanding of translational regulation and mRNA stability control.	Iron	57-61	Wnt family member 2	Homo sapiens	131-134
8670839-7	1996	Thus, the environmental signal resulting from iron deprivation was transduced through the regulated binding of AFT1 to the FET3 promoter, followed by the activation of transcription.	Iron	13-17	ferroxidase FET3	Saccharomyces cerevisiae S288C	123-127
8647926-8	1996	It is concluded, first, that toxic effects of iron and heme can be prevented by apo-transferrin or apo-hemopexin and, second, that exposure of RPE cells to free heme or hemopexin sets in motion a series of biochemical events resulting in protection against oxidative stress.	Iron	46-50	hemopexin	Homo sapiens	103-112
8647926-8	1996	It is concluded, first, that toxic effects of iron and heme can be prevented by apo-transferrin or apo-hemopexin and, second, that exposure of RPE cells to free heme or hemopexin sets in motion a series of biochemical events resulting in protection against oxidative stress.	Iron	46-50	hemopexin	Homo sapiens	169-178
8787027-4	1996	In root tips of the Fe-deficient wild type and the Fe-sufficient as well as the Fe-deficient mutant, the expression of glyceraldehyde-3-phosphate dehydrogenase, formate dehydrogenase, and ascorbate peroxidase was increased.	Iron	20-22	glyceraldehyde 3-phosphate dehydrogenase	Solanum lycopersicum	119-159
8787027-4	1996	In root tips of the Fe-deficient wild type and the Fe-sufficient as well as the Fe-deficient mutant, the expression of glyceraldehyde-3-phosphate dehydrogenase, formate dehydrogenase, and ascorbate peroxidase was increased.	Iron	51-53	glyceraldehyde 3-phosphate dehydrogenase	Solanum lycopersicum	119-159
8787027-4	1996	In root tips of the Fe-deficient wild type and the Fe-sufficient as well as the Fe-deficient mutant, the expression of glyceraldehyde-3-phosphate dehydrogenase, formate dehydrogenase, and ascorbate peroxidase was increased.	Iron	51-53	glyceraldehyde 3-phosphate dehydrogenase	Solanum lycopersicum	119-159
8661525-5	1996	Succinate dehydrogenase (SDH) and hexosaminidase (HEX) activities were reduced in dose-dependent manner, as was the antioxidative enzyme glucose-6-phosphate dehydrogenase (G-6-PDH) with both forms of iron.	Iron	200-204	glucose-6-phosphate 1-dehydrogenase	Chlorocebus sabaeus	137-170
8661525-5	1996	Succinate dehydrogenase (SDH) and hexosaminidase (HEX) activities were reduced in dose-dependent manner, as was the antioxidative enzyme glucose-6-phosphate dehydrogenase (G-6-PDH) with both forms of iron.	Iron	200-204	glucose-6-phosphate 1-dehydrogenase	Chlorocebus sabaeus	172-179
21544436-2	1996	Receptor upregulation results in the reconstitution of intracellular iron levels in the IFN alpha-treated cells.	Iron	69-73	interferon alpha 2	Homo sapiens	88-97
8871401-2	1996	Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels.	Iron	44-48	aconitase 1	Homo sapiens	145-186
8871401-2	1996	Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels.	Iron	44-48	aconitase 1	Homo sapiens	188-192
8871401-2	1996	Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels.	Iron	145-149	aconitase 1	Homo sapiens	188-192
8668693-4	1996	Histologically, mucin is recognized after special staining techniques using alcian blue and colloidal iron.	Iron	102-106	LOC100508689	Homo sapiens	16-21
8639920-1	1996	Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures known as iron-responsive elements (IREs).	Iron	109-113	aconitase 1	Rattus norvegicus	26-30
8639920-4	1996	IRP1 and IRP2 binding activities are regulated by intracellular iron levels.	Iron	64-68	aconitase 1	Rattus norvegicus	0-4
8639920-16	1996	in rat hepatoma cells, suggesting a role for IRP1 in the regulation of iron homeostasis in vivo during hepatic inflammation.	Iron	71-75	aconitase 1	Rattus norvegicus	45-49
8730630-1	1996	The aim of this study was to examine the capacity of the syncytiotrophoblast to regulate transferrin receptor (TfR) synthesis in response to modulations in maternal iron supply.	Iron	165-169	transferrin receptor	Homo sapiens	89-109
8730630-1	1996	The aim of this study was to examine the capacity of the syncytiotrophoblast to regulate transferrin receptor (TfR) synthesis in response to modulations in maternal iron supply.	Iron	165-169	transferrin receptor	Homo sapiens	111-114
8730630-6	1996	Iron deprivation by DFO resulted in clear stimulation of TfR synthesis.	Iron	0-4	transferrin receptor	Homo sapiens	57-60
8730630-7	1996	These results show that the differentiating trophoblast cells respond to pertubations in the (transferrin-mediated) iron supply by adjustments in the rate of TfR synthesis.	Iron	116-120	transferrin receptor	Homo sapiens	158-161
8636154-1	1996	Iron regulatory proteins (IRPs) are RNA-binding proteins that post-transcriptionally regulate synthesis of iron uptake (transferrin receptor) and storage (ferritin) proteins.	Iron	107-111	transferrin receptor	Homo sapiens	120-140
8636154-2	1996	Our previous work demonstrating that IRP1 is phosphorylated by protein kinase C supported the hypothesis that factors in addition to iron modulate IRP function.	Iron	133-137	aconitase 1	Homo sapiens	37-41
8599111-2	1996	Two proteins in the plasma membrane of yeast--a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene--were shown to mediate high-affinity iron uptake.	Iron	173-177	ferroxidase FET3	Saccharomyces cerevisiae S288C	84-88
8705293-1	1996	One method of iron transport across the blood brain barrier (BBB) involves the transferrin receptor (TR), which is localized to the specialized brain capillary endothelium.	Iron	14-18	transferrin receptor	Homo sapiens	79-99
8705293-1	1996	One method of iron transport across the blood brain barrier (BBB) involves the transferrin receptor (TR), which is localized to the specialized brain capillary endothelium.	Iron	14-18	transferrin receptor	Homo sapiens	101-103
8611587-4	1996	We have characterized the nNOS heme iron and flavin semiquinone radical by electron paramagnetic resonance (EPR) spectroscopy.	Iron	36-40	nitric oxide synthase 1	Homo sapiens	26-30
8611587-6	1996	The flavin radical, probably the semiquinone FMNH., was shown by progressive microwave power saturation and EPR saturation recovery under anaerobic conditions to be spin-spin coupled with the heme iron located in the nNOS oxygenase domain.	Iron	197-201	nitric oxide synthase 1	Homo sapiens	217-221
8611587-13	1996	Substrate binding also appears to take place outside the first coordination shell of the nNOS heme iron.	Iron	99-103	nitric oxide synthase 1	Homo sapiens	89-93
8643666-9	1996	As a test of this hypothesis, we predicted that mice which have altered expression of class I gene products, the beta2-microglobulin knockout mice, [beta2m(-/-)], would develop Fe overload.	Iron	177-179	beta-2 microglobulin	Mus musculus	113-132
8619794-4	1996	Both compounds inactivated LOX-2 by reducing the catalytic iron to the inactive Fe(II) form and counteracted the H2O2-mediated activation of the LOX-2 catalyzed dioxygenase reaction.	Iron	59-63	seed linoleate 9S-lipoxygenase-2	Glycine max	27-32
8567693-2	1996	Iron regulatory protein (IRP) is a cytosolic bifunctional [Fe-S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA.	Iron	116-120	wingless-type MMTV integration site family, member 2	Mus musculus	0-23
8567693-2	1996	Iron regulatory protein (IRP) is a cytosolic bifunctional [Fe-S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA.	Iron	116-120	wingless-type MMTV integration site family, member 2	Mus musculus	25-28
8969812-2	1996	Enhancement of the therapeutic benefit of recombinant human erythropoietin (rhEp) in very-low-birth-weight infants will require a better understanding of rhEp"s pharmacodynamic effects including its interaction with iron in stimulating erythropoiesis.	Iron	216-220	factor interacting with PAPOLA and CPSF1	Homo sapiens	76-80
8969812-3	1996	The purpose of this study was to determine the effects of chronic rhEp administration on plasma iron levels and hematopoiesis using a twin lamb model.	Iron	96-100	factor interacting with PAPOLA and CPSF1	Homo sapiens	66-70
8969812-6	1996	During the rhEp treatment period, significantly greater negative daily AUCs were observed in the rhEp-treated lambs for plasma iron concentration (p = 0.0008), while significantly greater positive daily AUCs were observed for hemoglobin concentration (p = 0.04) and reticulocyte count (p = 0.02).	Iron	127-131	factor interacting with PAPOLA and CPSF1	Homo sapiens	11-15
8969812-6	1996	During the rhEp treatment period, significantly greater negative daily AUCs were observed in the rhEp-treated lambs for plasma iron concentration (p = 0.0008), while significantly greater positive daily AUCs were observed for hemoglobin concentration (p = 0.04) and reticulocyte count (p = 0.02).	Iron	127-131	factor interacting with PAPOLA and CPSF1	Homo sapiens	97-101
8969812-7	1996	In the rhEp-treated group, pretreatment iron concentrations were directly associated with the magnitude of the iron response during treatment such that the greater the pretreatment iron, the greater the daily AUC below the plasma iron concentration-time plot (r = -0.66, p = 0.05).	Iron	40-44	factor interacting with PAPOLA and CPSF1	Homo sapiens	7-11
8969812-7	1996	In the rhEp-treated group, pretreatment iron concentrations were directly associated with the magnitude of the iron response during treatment such that the greater the pretreatment iron, the greater the daily AUC below the plasma iron concentration-time plot (r = -0.66, p = 0.05).	Iron	111-115	factor interacting with PAPOLA and CPSF1	Homo sapiens	7-11
8969812-7	1996	In the rhEp-treated group, pretreatment iron concentrations were directly associated with the magnitude of the iron response during treatment such that the greater the pretreatment iron, the greater the daily AUC below the plasma iron concentration-time plot (r = -0.66, p = 0.05).	Iron	111-115	factor interacting with PAPOLA and CPSF1	Homo sapiens	7-11
8969812-7	1996	In the rhEp-treated group, pretreatment iron concentrations were directly associated with the magnitude of the iron response during treatment such that the greater the pretreatment iron, the greater the daily AUC below the plasma iron concentration-time plot (r = -0.66, p = 0.05).	Iron	111-115	factor interacting with PAPOLA and CPSF1	Homo sapiens	7-11
8969812-9	1996	These observations suggest that treatment of rapidly growing newborn lambs with rhEp results in increased iron utilization due to increased erythropoiesis and depends on iron status at the initiation of rhEp treatment.	Iron	106-110	factor interacting with PAPOLA and CPSF1	Homo sapiens	80-84
8969812-9	1996	These observations suggest that treatment of rapidly growing newborn lambs with rhEp results in increased iron utilization due to increased erythropoiesis and depends on iron status at the initiation of rhEp treatment.	Iron	170-174	factor interacting with PAPOLA and CPSF1	Homo sapiens	80-84
8969812-9	1996	These observations suggest that treatment of rapidly growing newborn lambs with rhEp results in increased iron utilization due to increased erythropoiesis and depends on iron status at the initiation of rhEp treatment.	Iron	170-174	factor interacting with PAPOLA and CPSF1	Homo sapiens	203-207
8903680-2	1996	Regulation of ferritin occurs through the formation of an iron-sulfur cluster within a cytoplasmic protein, the iron regulatory protein (IRP) that controls ferritin mRNA translation.	Iron	58-62	Wnt family member 2	Homo sapiens	112-135
8903680-2	1996	Regulation of ferritin occurs through the formation of an iron-sulfur cluster within a cytoplasmic protein, the iron regulatory protein (IRP) that controls ferritin mRNA translation.	Iron	58-62	Wnt family member 2	Homo sapiens	137-140
7493976-1	1995	Transferrin receptor (TfR) mRNA expression is tightly linked to intracellular iron levels.	Iron	78-82	transferrin receptor	Homo sapiens	0-20
7493976-1	1995	Transferrin receptor (TfR) mRNA expression is tightly linked to intracellular iron levels.	Iron	78-82	transferrin receptor	Homo sapiens	22-25
7493976-4	1995	In order to get more information about factors involved in this process we investigated the in vivo IRP-RNA interaction and the effect of transcription inhibitors on the iron-dependent decay of TfR mRNA.	Iron	170-174	transferrin receptor	Homo sapiens	194-197
7493976-6	1995	High intracellular iron levels led to a drastic reduction of this active RNA-bound IRP in vivo, indicating that IRP dissociates prior to TfR mRNA decay.	Iron	19-23	Wnt family member 2	Homo sapiens	83-86
7493976-6	1995	High intracellular iron levels led to a drastic reduction of this active RNA-bound IRP in vivo, indicating that IRP dissociates prior to TfR mRNA decay.	Iron	19-23	Wnt family member 2	Homo sapiens	112-115
7493976-6	1995	High intracellular iron levels led to a drastic reduction of this active RNA-bound IRP in vivo, indicating that IRP dissociates prior to TfR mRNA decay.	Iron	19-23	transferrin receptor	Homo sapiens	137-140
7492760-5	1995	This mutation involves the five nucleotides sequence [CAGUG] of the iron-responsive element (IRE), which is critical for the posttranscriptional regulation of ferritin synthesis by means of IRE-binding protein (IRE-BP).	Iron	68-72	aconitase 1	Homo sapiens	190-209
7492760-5	1995	This mutation involves the five nucleotides sequence [CAGUG] of the iron-responsive element (IRE), which is critical for the posttranscriptional regulation of ferritin synthesis by means of IRE-binding protein (IRE-BP).	Iron	68-72	aconitase 1	Homo sapiens	211-217
8847538-7	1995	Several investigators reported the presence of other iron-related proteins in the central nervous system, including transferrin, transferrin receptor, and the ferritin repressor protein.	Iron	53-57	aconitase 1	Homo sapiens	159-185
8544218-0	1995	Soluble transferrin receptor as an index of iron status in Zairian children with malaria.	Iron	44-48	transferrin receptor	Homo sapiens	8-28
8544218-1	1995	This study was designed to evaluate soluble transferrin receptor (sTfR) as an index of iron status in 0.5-16-year-old Zairian children: 17 with symptomatic malaria, 8 with asymptomatic malaria, and 15 controls.	Iron	87-91	transferrin receptor	Homo sapiens	44-64
7489724-6	1995	The deletion of this sequence eliminates the rapid turnover of IRP2, whereas the transfer of this sequence to the corresponding position in the homologous protein IRP1 confers the capacity for iron-dependent degradation upon IRP1.	Iron	193-197	aconitase 1	Homo sapiens	163-167
7489724-6	1995	The deletion of this sequence eliminates the rapid turnover of IRP2, whereas the transfer of this sequence to the corresponding position in the homologous protein IRP1 confers the capacity for iron-dependent degradation upon IRP1.	Iron	193-197	aconitase 1	Homo sapiens	225-229
7558284-1	1995	Haemophilus influenzae has the ability to obtain iron from human transferrin via two bacterial cell surface transferrin binding proteins, Tbp1 and Tbp2.	Iron	49-53	TATA-box binding protein like 2	Homo sapiens	147-151
7577640-2	1995	A significant increase in the absorption of 59Fe-tagged food iron fed to fasting rats was observed when two subcutaneous injections of IL-11 were given 48 and 24 h prior to testing.	Iron	61-65	interleukin 11	Rattus norvegicus	135-140
8578805-1	1995	During iron-limited growth Neisseria meningitidis expresses two transferrin binding proteins, TBP1 and TBP2, with molecular masses of approximately 98 and 65-90 kDa depending on strain.	Iron	7-11	TATA-box binding protein like 2	Homo sapiens	103-107
7653595-6	1995	There was no enzymatic evidence of lysosomal fragility, and chronic iron loading of RK decreased fragility as assessed by NAG release (1.36 +/- 0.14 vs. 2.17 +/- 0.14; P &lt; 0.05).	Iron	68-72	O-GlcNAcase	Rattus norvegicus	122-125
7642502-9	1995	ADH is a homotetramer with a subunit M(r) of 46,000 and contains 1 g-atom of Fe per subunit, which, as determined by electron paramagnetic resonance analyses, is present as a mixture of ferrous and ferric forms.	Iron	77-79	iron-containing alcohol dehydrogenase	Thermococcus paralvinellae	0-3
7652154-3	1995	The entire hprt gene (&gt; 44 kb) was missing in 19/39 Fe-induced mutants, while only 2/30 spontaneous mutants lost the entire hprt coding sequence.	Iron	55-57	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	11-15
7742556-1	1995	Nitric oxide (NO) is known to increase the affinity of the intracellular iron-regulatory protein (IRP) for iron-response elements (IREs) in transferrin receptor and ferritin mRNAs, suggesting that it may act as a regulator of cellular iron metabolism.	Iron	73-77	Wnt family member 2	Homo sapiens	98-101
7742556-1	1995	Nitric oxide (NO) is known to increase the affinity of the intracellular iron-regulatory protein (IRP) for iron-response elements (IREs) in transferrin receptor and ferritin mRNAs, suggesting that it may act as a regulator of cellular iron metabolism.	Iron	73-77	transferrin receptor	Homo sapiens	140-160
7742556-1	1995	Nitric oxide (NO) is known to increase the affinity of the intracellular iron-regulatory protein (IRP) for iron-response elements (IREs) in transferrin receptor and ferritin mRNAs, suggesting that it may act as a regulator of cellular iron metabolism.	Iron	107-111	Wnt family member 2	Homo sapiens	73-96
7742556-1	1995	Nitric oxide (NO) is known to increase the affinity of the intracellular iron-regulatory protein (IRP) for iron-response elements (IREs) in transferrin receptor and ferritin mRNAs, suggesting that it may act as a regulator of cellular iron metabolism.	Iron	107-111	Wnt family member 2	Homo sapiens	98-101
7742556-1	1995	Nitric oxide (NO) is known to increase the affinity of the intracellular iron-regulatory protein (IRP) for iron-response elements (IREs) in transferrin receptor and ferritin mRNAs, suggesting that it may act as a regulator of cellular iron metabolism.	Iron	107-111	transferrin receptor	Homo sapiens	140-160
7672357-0	1995	Duodenal expression of NF-E2 in mouse models of altered iron metabolism.	Iron	56-60	nuclear factor, erythroid derived 2	Mus musculus	23-28
7585245-1	1995	The iron regulatory protein (IRP) is a cytoplasmic RNA-binding protein that regulates cellular iron metabolism at the posttranscriptional level.	Iron	4-8	Wnt family member 2	Homo sapiens	29-32
7585245-2	1995	IRP is an unusual bifunctional molecule: in iron-replete cells it predominantly exists as a 4Fe-4S protein and exhibits aconitase enzymatic activity, whereas apo-IRP prevails in iron-starved cells and binds to iron-responsive elements (IREs), structural motifs within the untranslated regions of mRNAs involved in iron metabolism.	Iron	44-48	Wnt family member 2	Homo sapiens	0-3
7585245-2	1995	IRP is an unusual bifunctional molecule: in iron-replete cells it predominantly exists as a 4Fe-4S protein and exhibits aconitase enzymatic activity, whereas apo-IRP prevails in iron-starved cells and binds to iron-responsive elements (IREs), structural motifs within the untranslated regions of mRNAs involved in iron metabolism.	Iron	178-182	Wnt family member 2	Homo sapiens	0-3
7585245-2	1995	IRP is an unusual bifunctional molecule: in iron-replete cells it predominantly exists as a 4Fe-4S protein and exhibits aconitase enzymatic activity, whereas apo-IRP prevails in iron-starved cells and binds to iron-responsive elements (IREs), structural motifs within the untranslated regions of mRNAs involved in iron metabolism.	Iron	178-182	Wnt family member 2	Homo sapiens	0-3
7585245-2	1995	IRP is an unusual bifunctional molecule: in iron-replete cells it predominantly exists as a 4Fe-4S protein and exhibits aconitase enzymatic activity, whereas apo-IRP prevails in iron-starved cells and binds to iron-responsive elements (IREs), structural motifs within the untranslated regions of mRNAs involved in iron metabolism.	Iron	178-182	Wnt family member 2	Homo sapiens	0-3
7868259-6	1995	Finally, Tbp2-specific immunoglobulins were able to lower the growth rate of the meningococci when human transferrin was their sole iron source.	Iron	132-136	TATA-box binding protein like 2	Homo sapiens	9-13
7783054-9	1995	In patients with RA, IL-2R correlated weakly with ESR (r = 0.24, p &lt; 0.05), iron concentration (r = -0.35, p &lt; 0.005), and CRP (r = 0.24, p &lt; 0.05).	Iron	79-83	interleukin 2 receptor subunit alpha	Homo sapiens	21-26
12228362-2	1995	The relative transcript levels of wali1 (encoding a plant metallothionein-like protein), wali3 and wali5 (putative Bowman-Birk proteinase inhibitors), and wali4 (phenylalanine ammonialyase) increased in root tips of wheat after 2-d treatments with toxic levels of all other metals tested (Cd, Fe, Zn, Cu, Ga, In, and La).	Iron	293-295	metallothionein-like protein 1	Triticum aestivum	34-39
12228362-2	1995	The relative transcript levels of wali1 (encoding a plant metallothionein-like protein), wali3 and wali5 (putative Bowman-Birk proteinase inhibitors), and wali4 (phenylalanine ammonialyase) increased in root tips of wheat after 2-d treatments with toxic levels of all other metals tested (Cd, Fe, Zn, Cu, Ga, In, and La).	Iron	293-295	wali4	Triticum aestivum	155-160
7825519-3	1995	Copper deficiency, as demonstrated by low plasma copper and ceruloplasmin, caused a decrease of liver, heart, and testes copper; a decline of liver and heart zinc; and an increase of hepatic iron.	Iron	191-195	ceruloplasmin	Rattus norvegicus	60-73
8643370-3	1995	RNA interactions with the IRP are modulated by cellular iron.	Iron	56-60	Wnt family member 2	Homo sapiens	26-29
7809162-2	1994	The dynamic properties of the iron-sulfur (Fe-S) cluster of the iron responsive-element binding protein (IRE-BP) suggested that it might serve as a target for NO produced in response to glutamatergic stimulation in neurons.	Iron	43-47	aconitase 1	Homo sapiens	64-103
7809162-2	1994	The dynamic properties of the iron-sulfur (Fe-S) cluster of the iron responsive-element binding protein (IRE-BP) suggested that it might serve as a target for NO produced in response to glutamatergic stimulation in neurons.	Iron	43-47	aconitase 1	Homo sapiens	105-111
7881153-1	1994	Cellular iron metabolism comprises pathways of iron-protein synthesis and degradation, iron uptake via transferrin receptor (TfR) or release to the extracellular space, as well as iron deposition into ferritin and remobilization from such stores.	Iron	9-13	transferrin receptor	Homo sapiens	103-123
7881153-1	1994	Cellular iron metabolism comprises pathways of iron-protein synthesis and degradation, iron uptake via transferrin receptor (TfR) or release to the extracellular space, as well as iron deposition into ferritin and remobilization from such stores.	Iron	9-13	transferrin receptor	Homo sapiens	125-128
7881153-5	1994	Under conditions of iron chelation, IRP is an apo-protein which binds with high affinity to specific RNA stem-loop elements (IREs) located 5" of the initiation codon in ferritin and eALAS mRNA, and 3" in the untranslated region of TfR mRNA.	Iron	20-24	Wnt family member 2	Homo sapiens	36-39
7881153-8	1994	Under high iron conditions, IRP is converted to the holo-protein and dissociates from mRNA.	Iron	11-15	Wnt family member 2	Homo sapiens	28-31
7881153-12	1994	Moreover measurements of the RNA-binding activity of IRP in tissue extracts may provide valuable information on iron availability.	Iron	112-116	Wnt family member 2	Homo sapiens	53-56
7947969-6	1994	One heme group (protoporphyrin IX with an iron atom in the ferric state) is associated with one molecule of hCP.	Iron	42-46	coproporphyrinogen oxidase	Homo sapiens	108-111
7523370-4	1994	The 4Fe-4S cluster is important for iron-dependent regulation: BP1 containing iron has low affinity for the IRE and contains aconitase activity, whereas BP1 lacking iron has high affinity for the IRE, but lacks aconitase activity.	Iron	36-40	Blood pressure QTL 1	Rattus norvegicus	63-66
8074667-5	1994	Intracellular iron levels are known to regulate TRF-R expression: we have, therefore, evaluated whether changes in the iron content could be determined by IFN alpha.	Iron	14-18	transferrin receptor	Homo sapiens	48-53
8078898-0	1994	Roles of heme iron-coordinating histidine residues of human hemopexin expressed in baculovirus-infected insect cells.	Iron	14-18	hemopexin	Homo sapiens	60-69
8078898-9	1994	1H NMR data indicate that each of the single-mutant heme-Hx complexes is predominantly low-spin, perhaps owing to coordination of the heme iron by the Thr side-chain oxygen or water oxygen coordinating to the iron.	Iron	139-143	hemopexin	Homo sapiens	57-59
8078898-9	1994	1H NMR data indicate that each of the single-mutant heme-Hx complexes is predominantly low-spin, perhaps owing to coordination of the heme iron by the Thr side-chain oxygen or water oxygen coordinating to the iron.	Iron	209-213	hemopexin	Homo sapiens	57-59
8045562-0	1994	Exclusion of ferritins and iron-responsive element (IRE)-binding proteins as candidates for the hemochromatosis gene.	Iron	27-31	homeostatic iron regulator	Homo sapiens	96-111
8002525-0	1994	Interaction of transferrin saturated with iron with lung surfactant in respiratory failure.	Iron	42-46	serotransferrin	Oryctolagus cuniculus	15-26
8002525-4	1994	Unlike serum TF, TF recovered in respiratory failure was saturated with iron (Fe(3+)-TF).	Iron	72-76	serotransferrin	Oryctolagus cuniculus	17-19
8002525-4	1994	Unlike serum TF, TF recovered in respiratory failure was saturated with iron (Fe(3+)-TF).	Iron	72-76	serotransferrin	Oryctolagus cuniculus	17-19
8002525-5	1994	Fe(3+)-TF decreased the surface activity of normal surfactant in vitro, whereas iron-free TF had no effect.	Iron	80-84	serotransferrin	Oryctolagus cuniculus	90-92
8002525-8	1994	In respiratory failure induced by BAL, Fe(3+)-TF deteriorated respiratory failure, whereas iron-free TF had no effect.	Iron	91-95	serotransferrin	Oryctolagus cuniculus	101-103
8002525-9	1994	In respiratory failure induced by hyperoxia for 48 h, administration of iron-free TF ameliorated the respiratory failure and improved the surface activity in BAL.	Iron	72-76	serotransferrin	Oryctolagus cuniculus	82-84
8034623-15	1994	Moreover, because NifS has recently been shown to be a member of a highly homologous gene family, it appears that pyridoxal phosphate chemistry might play a general role in iron-sulfur cluster assembly.	Iron	173-177	NFS1 cysteine desulfurase	Homo sapiens	18-22
7806210-5	1994	An additional syntenic cluster exists within a peak of linkage disequilibrium with the HFE gene and may define coding sequences that underlie the defect in genetic iron overload.	Iron	164-168	homeostatic iron regulator	Homo sapiens	87-90
8203918-1	1994	The iron-responsive element-binding protein (IRE-BP) has been defined and identified as an RNA-binding protein found in iron-deprived eukaryotic cells.	Iron	4-8	aconitase 1	Homo sapiens	45-51
8203918-2	1994	IRE-BP binds to stem-loop structures, iron-responsive elements (IREs), which are located in the untranslated regions of the mRNAs for several genes including ferritin, and the transferrin receptor.	Iron	38-42	aconitase 1	Homo sapiens	0-6
8203918-4	1994	When cells are iron replete, an iron-sulfur cluster is ligated to the IRE-BP, the protein loses RNA binding properties, and it acquires aconitase activity.	Iron	15-19	aconitase 1	Homo sapiens	70-76
8203918-4	1994	When cells are iron replete, an iron-sulfur cluster is ligated to the IRE-BP, the protein loses RNA binding properties, and it acquires aconitase activity.	Iron	32-36	aconitase 1	Homo sapiens	70-76
8203918-5	1994	Cytosolic aconitase from liver can be converted into the IRE-BP by oxidative removal of its Fe-S cluster.	Iron	92-96	aconitase 1	Homo sapiens	57-63
8203918-6	1994	We describe here overexpression of IRE-BP in baculovirus-infected insect cells which yields IRE-BP devoid of an iron-sulfur cluster.	Iron	112-116	aconitase 1	Homo sapiens	35-41
8203918-10	1994	Active aconitase could be reconstituted from the purified IRE-BP obtained from the expression system by addition of iron, thiol, and sulfide, and the characteristic epr spectrum of the 3Fe form of cytosolic aconitase was obtained after ferricyanide oxidation of the reconstituted material.	Iron	116-120	aconitase 1	Homo sapiens	58-64
8198599-1	1994	Ferritin synthesis is known to be regulated translationally by specific mRNA-protein interactions between an iron-responsive element (IRE) localized in the 5" untranslated region of ferritin mRNA and IRE-binding protein (IRE-BP).	Iron	109-113	aconitase 1	Homo sapiens	200-219
8198599-1	1994	Ferritin synthesis is known to be regulated translationally by specific mRNA-protein interactions between an iron-responsive element (IRE) localized in the 5" untranslated region of ferritin mRNA and IRE-binding protein (IRE-BP).	Iron	109-113	aconitase 1	Homo sapiens	221-227
8168920-1	1994	The diphtheria toxin repressor (DtxR) is an iron-dependent regulator of diphtheria toxin production and iron uptake in Corynebacterium diphtheriae.	Iron	44-48	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
8168920-1	1994	The diphtheria toxin repressor (DtxR) is an iron-dependent regulator of diphtheria toxin production and iron uptake in Corynebacterium diphtheriae.	Iron	44-48	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
8168920-1	1994	The diphtheria toxin repressor (DtxR) is an iron-dependent regulator of diphtheria toxin production and iron uptake in Corynebacterium diphtheriae.	Iron	104-108	MarR family transcriptional regulator	Corynebacterium diphtheriae	4-30
8168920-1	1994	The diphtheria toxin repressor (DtxR) is an iron-dependent regulator of diphtheria toxin production and iron uptake in Corynebacterium diphtheriae.	Iron	104-108	MarR family transcriptional regulator	Corynebacterium diphtheriae	32-36
8163564-0	1994	Role of membrane surface potential and other factors in the uptake of non-transferrin-bound iron by reticulocytes.	Iron	92-96	serotransferrin	Oryctolagus cuniculus	74-85
8163564-1	1994	Reticulocytes suspended in low ionic strength media such as isotonic sucrose solution efficiently take up non-transferrin-bound iron and utilize it for heme synthesis.	Iron	128-132	serotransferrin	Oryctolagus cuniculus	110-121
8025673-3	1994	During iron-limited growth mRNA levels for Tpi1p and Tdh3p were at least 3-fold lower than during iron-saturated growth; as shown with a hem1 mutant strain this regulation does not require haem synthesis.	Iron	7-11	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3	Saccharomyces cerevisiae S288C	53-58
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	61-65	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3	Saccharomyces cerevisiae S288C	25-29
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	103-107	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3	Saccharomyces cerevisiae S288C	25-29
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	103-107	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3	Saccharomyces cerevisiae S288C	25-29
8025673-4	1994	mRNA half-lives of TPI1 (TDH3) were 11.5 min (18 min) in low-iron medium and 30 min (32.5 min) in high-iron medium, indicating iron-regulation of transcript half-lives; the stabilities of the ACT1 and PDC1 transcripts were not influenced by iron.	Iron	103-107	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3	Saccharomyces cerevisiae S288C	25-29
8145237-10	1994	In contrast, the aryl carbon atoms ortho to the phenolic group of APAP approach closer to the heme iron of CYP2B1 (3.19 +/- 0.12 A) than to the heme iron of CPY1A1 (3.66 +/- 0.30 A).	Iron	99-103	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	107-113
9371267-2	1994	Molecular mechanisms for the cellular uptake, storage, and utilization of iron were clarified in investigations of the structure and functions of transferrin, transferrin receptor, ferritin, erythroid delta-aminolevulinic acid synthase, and the RNA-binding protein termed the iron responsive-element binding protein.	Iron	74-78	transferrin receptor	Homo sapiens	159-179
14731597-3	1994	IRP is a cytoplasmic protein that coordinates cellular iron traffic by binding to iron-responsive elements in mRNAs encoding proteins involved in iron uptake, storage and utilization.	Iron	55-59	Wnt family member 2	Homo sapiens	0-3
14731597-3	1994	IRP is a cytoplasmic protein that coordinates cellular iron traffic by binding to iron-responsive elements in mRNAs encoding proteins involved in iron uptake, storage and utilization.	Iron	82-86	Wnt family member 2	Homo sapiens	0-3
14731597-3	1994	IRP is a cytoplasmic protein that coordinates cellular iron traffic by binding to iron-responsive elements in mRNAs encoding proteins involved in iron uptake, storage and utilization.	Iron	82-86	Wnt family member 2	Homo sapiens	0-3
8117105-9	1994	The purified human P450 1A2 was found to be almost completely in the high spin iron configuration, in contrast to P450 1A2 enzymes isolated from rats and rabbits.	Iron	79-83	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-23
8106325-1	1994	DtxR is an iron-dependent sequence-specific DNA-binding protein that binds to the tox operator, an inverted-repeat nucleotide sequence located upstream from the diphtheria toxin gene.	Iron	11-15	MarR family transcriptional regulator	Corynebacterium diphtheriae	0-4
8106325-2	1994	In this study, two additional iron-regulated promoter/operator sequences (IRP1 and IRP2) that are controlled by DtxR were cloned from the chromosome of Corynebacterium diphtheriae and characterized.	Iron	30-34	MarR family transcriptional regulator	Corynebacterium diphtheriae	112-116
8106325-4	1994	Transcription from both promoters was strongly repressed in high-iron medium in the presence of the cloned dtxR gene; however, transcription in the absence of dtxR was 50- to 100-fold greater, regardless of the iron concentration.	Iron	65-69	MarR family transcriptional regulator	Corynebacterium diphtheriae	107-111
7832041-3	1994	When coupled with the serum ferritin, the serum transferrin receptor concentration provides a sensitive, quantitative index of iron status over a wide spectrum.	Iron	127-131	transferrin receptor	Homo sapiens	48-68
11538026-9	1994	The action cross section for induction of hprt-deficient mutants by energetic Fe ions is more than 10-fold lower for lymphoblastoid cells than for fibroblasts.	Iron	78-80	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	42-46
8127021-8	1994	To assess its potential usefulness as a tool for studying injury and repair, HK-2 cells were exposed to a toxic concentration of H2O2 +/- iron chelation (deferoxamine) or hydroxyl radical scavenger (Na benzoate) therapy.	Iron	138-142	hexokinase 2	Homo sapiens	77-81
8413301-2	1993	While recent reports have clearly demonstrated that GATA-1 is involved in the induction of erythroid cell-specific forms of 5-aminolevulinate synthase (ALAS-2) and porphobilinogen (PBG) deaminase and that cellular iron status plays a regulatory role for ALAS-2, little is known about regulation of the remainder of the pathway.	Iron	214-218	GATA binding protein 1	Mus musculus	52-58
8379943-7	1993	In contrast with HL60 cells, CCRF-CEM cells displayed a decrease in the level of TfR mRNA after incubation with Tf-Ga. Tf-Ga inhibited iron uptake in both HL60 and CCRF-CEM cells but increased the level of TfR mRNA only in HL60 cells, suggesting that the Tf-Ga induction of TfR mRNA was not solely due to inhibition of cellular iron uptake.	Iron	328-332	transferrin receptor	Homo sapiens	81-84
8379943-9	1993	Our studies suggest that in HL60 cells, gallium regulates TfR expression at the post-transcriptional level by mechanisms which require de novo protein synthesis and involve interaction with iron.	Iron	190-194	transferrin receptor	Homo sapiens	58-61
8214084-7	1993	Pretreatment of EC with the iron chelator deferoxamine mesylate (1-10 mM) for 4 h attenuated the PMN-mediated decrease in ACE activity, as did the thiol reducing agent, 2-mercaptoethanol (0.1 mM), and the myeloperoxidase inhibitor, cyanide (5 mM), but not azide (1-50 mM).	Iron	28-32	angiotensin I converting enzyme	Bos taurus	122-125
8364209-6	1993	However, when a physiologic concentration of Tf-Fe is added to an equimolar concentration of Tf-Ga, significant Fe incorporation is evident despite inhibition of proliferation.	Iron	48-50	transforming growth factor alpha	Homo sapiens	93-98
8364209-6	1993	However, when a physiologic concentration of Tf-Fe is added to an equimolar concentration of Tf-Ga, significant Fe incorporation is evident despite inhibition of proliferation.	Iron	112-114	transforming growth factor alpha	Homo sapiens	93-98
8358725-5	1993	Neuroblastoma cells treated with DFO adapt appropriately to Fe chelation as measured by marked upregulation of transferrin receptor mRNA, increased functional transferrin receptor, and decreased cellular ferritin concentration.	Iron	60-62	transferrin receptor	Homo sapiens	111-131
7685392-1	1993	Ferritin and transferrin receptors are co-ordinately regulated by the same RNA-protein interaction: the conserved iron regulatory element (IRE) in mRNA and the IRE-binding protein (IRE-BP/IRP/FRP/P-90).	Iron	114-118	serotransferrin	Oryctolagus cuniculus	13-24
10005624-0	1993	Partial valence-band spectra of Fe in Cd1-xFexSe.	Iron	32-34	CD1c molecule	Homo sapiens	38-41
8471047-1	1993	Iron overload causes inhibition of hepatic uroporphyrinogen decarboxylase (UROD) and uroporphyria in C57BL/10ScSn but not DBA/2 mice [Smith, Cabral, Carthew, Francis and Manson (1989) Int.	Iron	0-4	uroporphyrinogen decarboxylase	Mus musculus	43-73
8471047-1	1993	Iron overload causes inhibition of hepatic uroporphyrinogen decarboxylase (UROD) and uroporphyria in C57BL/10ScSn but not DBA/2 mice [Smith, Cabral, Carthew, Francis and Manson (1989) Int.	Iron	0-4	uroporphyrinogen decarboxylase	Mus musculus	75-79
8464737-2	1993	Binding of IRF to iron-responsive elements (IRE) in the 5" untranslated region (UTR) of ferritin and erythroid 5-aminolevulinic acid-synthase mRNAs inhibits their translation, whereas binding to IREs in the 3" UTR of transferrin receptor (TfR) mRNA prevents the degradation of this mRNA.	Iron	18-22	transferrin receptor	Homo sapiens	217-237
8464737-2	1993	Binding of IRF to iron-responsive elements (IRE) in the 5" untranslated region (UTR) of ferritin and erythroid 5-aminolevulinic acid-synthase mRNAs inhibits their translation, whereas binding to IREs in the 3" UTR of transferrin receptor (TfR) mRNA prevents the degradation of this mRNA.	Iron	18-22	transferrin receptor	Homo sapiens	239-242
8502427-7	1993	However, when intracellular iron accumulates, IRE-BP releases its hold and translation of the mRNA then takes place.	Iron	28-32	aconitase 1	Homo sapiens	46-52
8502427-9	1993	Within each cluster one iron atom is labile; this may be the mechanism by which IRE-BP responds to intracellular iron levels.	Iron	24-28	aconitase 1	Homo sapiens	80-86
8502427-9	1993	Within each cluster one iron atom is labile; this may be the mechanism by which IRE-BP responds to intracellular iron levels.	Iron	113-117	aconitase 1	Homo sapiens	80-86
8476268-1	1993	The transferrin receptor plays a critical role in iron metabolism by precisely controlling the flow of transferrin iron into body cells.	Iron	50-54	transferrin receptor	Homo sapiens	4-24
8476268-1	1993	The transferrin receptor plays a critical role in iron metabolism by precisely controlling the flow of transferrin iron into body cells.	Iron	115-119	transferrin receptor	Homo sapiens	4-24
1281544-1	1992	The translation of ferritin mRNA and degradation of transferrin receptor mRNA are regulated by the interaction of an RNA-binding protein, the iron-responsive element binding protein (IRE-BP), with RNA stem-loop structures known as iron-responsive elements (IREs) contained within these transcripts.	Iron	142-146	transferrin receptor	Homo sapiens	52-72
1281544-1	1992	The translation of ferritin mRNA and degradation of transferrin receptor mRNA are regulated by the interaction of an RNA-binding protein, the iron-responsive element binding protein (IRE-BP), with RNA stem-loop structures known as iron-responsive elements (IREs) contained within these transcripts.	Iron	142-146	aconitase 1	Homo sapiens	183-189
1281544-2	1992	IRE-BP produced in iron-replete cells has aconitase (EC 4.2.1.3) activity.	Iron	19-23	aconitase 1	Homo sapiens	0-6
1281544-5	1992	This Fe-S cluster has been implicated as the region of the protein that senses intracellular iron levels and accordingly modifies the ability of the IRE-BP to interact with IREs.	Iron	93-97	aconitase 1	Homo sapiens	149-155
1281544-6	1992	Expression of the IRE-BP in cultured cells has revealed that the IRE-BP functions either as an active aconitase, when the cells are iron-replete, or as an active RNA-binding protein, when the cells are iron-depleted.	Iron	132-136	aconitase 1	Homo sapiens	18-24
1281544-6	1992	Expression of the IRE-BP in cultured cells has revealed that the IRE-BP functions either as an active aconitase, when the cells are iron-replete, or as an active RNA-binding protein, when the cells are iron-depleted.	Iron	132-136	aconitase 1	Homo sapiens	65-71
1281544-6	1992	Expression of the IRE-BP in cultured cells has revealed that the IRE-BP functions either as an active aconitase, when the cells are iron-replete, or as an active RNA-binding protein, when the cells are iron-depleted.	Iron	202-206	aconitase 1	Homo sapiens	18-24
1281544-6	1992	Expression of the IRE-BP in cultured cells has revealed that the IRE-BP functions either as an active aconitase, when the cells are iron-replete, or as an active RNA-binding protein, when the cells are iron-depleted.	Iron	202-206	aconitase 1	Homo sapiens	65-71
1281544-7	1992	We compare properties of purified authentic cytosolic aconitase from beef liver with those of IRE-BP from tissue culture cells and establish that characteristics of the physiologically relevant form of the protein from iron-depleted cells resemble those of cytosolic aconitase apoprotein.	Iron	219-223	aconitase 1	Homo sapiens	94-100
1447194-0	1992	Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation.	Iron	0-4	aconitase 1	Homo sapiens	35-74
1447194-1	1992	The iron-responsive element binding protein (IRE-BP) interacts with specific sequence/structure motifs (iron-responsive elements) within the mRNAs encoding ferritin and the transferrin receptor and thereby post-transcriptionally regulates the expression of these two proteins involved in cellular iron homeostasis.	Iron	4-8	aconitase 1	Homo sapiens	45-51
1447194-1	1992	The iron-responsive element binding protein (IRE-BP) interacts with specific sequence/structure motifs (iron-responsive elements) within the mRNAs encoding ferritin and the transferrin receptor and thereby post-transcriptionally regulates the expression of these two proteins involved in cellular iron homeostasis.	Iron	104-108	aconitase 1	Homo sapiens	4-43
1447194-1	1992	The iron-responsive element binding protein (IRE-BP) interacts with specific sequence/structure motifs (iron-responsive elements) within the mRNAs encoding ferritin and the transferrin receptor and thereby post-transcriptionally regulates the expression of these two proteins involved in cellular iron homeostasis.	Iron	104-108	aconitase 1	Homo sapiens	45-51
1447194-2	1992	The activity of the IRE-BP is itself regulated by iron such that when cells are treated with an iron source, the RNA binding activity is decreased.	Iron	50-54	aconitase 1	Homo sapiens	20-26
1447194-2	1992	The activity of the IRE-BP is itself regulated by iron such that when cells are treated with an iron source, the RNA binding activity is decreased.	Iron	96-100	aconitase 1	Homo sapiens	20-26
1447194-4	1992	In all cases, iron down-modulated the RNA binding activity of the IRE-BP, but in no instance was this decrease in activity accompanied by a decrease in the level of the protein as judged by quantitative Western blots.	Iron	14-18	aconitase 1	Homo sapiens	66-72
1447194-7	1992	These data are discussed in terms of a model of IRE-BP regulation involving the modification of the protein"s iron-sulfur center.	Iron	110-114	aconitase 1	Homo sapiens	48-54
1329954-14	1992	The low-temperature EPR spectrum of the [Fe-S] cluster is centered at g = 2.007 and undergoes power saturation at 10 K in a homogeneous manner, with a p1/2 of 15 +/- 2 mW.	Iron	41-43	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	Homo sapiens	151-161
1644822-15	1992	The concomitant regulation of gene expression of MT-1 and HO in response to heme-hemopexin appears to be a concerted adaptive response of the cells, mediated at the level of the plasma membrane hemopexin receptor, and may relate to the proposed role of MT as an intracellular antioxidant or to a need to sequester zinc which otherwise would compete with iron and occupy sites on regulatory proteins such as the iron-responsive elements.	Iron	354-358	hemopexin	Homo sapiens	81-90
1644822-15	1992	The concomitant regulation of gene expression of MT-1 and HO in response to heme-hemopexin appears to be a concerted adaptive response of the cells, mediated at the level of the plasma membrane hemopexin receptor, and may relate to the proposed role of MT as an intracellular antioxidant or to a need to sequester zinc which otherwise would compete with iron and occupy sites on regulatory proteins such as the iron-responsive elements.	Iron	411-415	hemopexin	Homo sapiens	81-90
1502165-9	1992	Furthermore, iron manipulation of cells correlates with the activation or inactivation of the IRE-BP aconitase activity.	Iron	13-17	aconitase 1	Homo sapiens	94-100
1502165-10	1992	The results are consistent with a model for the posttranslational regulation of the IRE-BP in which the Fe-S cluster is altered in response to the availability of intracellular iron and this, in turn, regulates the RNA-binding activity.	Iron	177-181	aconitase 1	Homo sapiens	84-90
1638529-0	1992	Inhibition of hematopoietic tumor growth by combined treatment with deferoxamine and an IgG monoclonal antibody against the transferrin receptor: evidence for a threshold model of iron deprivation toxicity.	Iron	180-184	transferrin receptor	Homo sapiens	124-144
1638529-2	1992	Thus, for example, we recently provided evidence that combined treatment with the iron chelator deferoxamine and an IgG monoclonal antibody against the transferrin receptor (ATRA) produces synergistic inhibition of hematopoietic tumor cell growth in vitro (J. D. Kemp, K. M. Smith, L. J. Kanner, F. Gomez, J.	Iron	82-86	transferrin receptor	Homo sapiens	152-172
1322290-8	1992	Zinc, cobalt and iron strongly inhibit MIP activity.	Iron	17-21	mitochondrial intermediate peptidase	Rattus norvegicus	39-42
1613493-2	1992	When cultures were switched for 24 h to serum-free conditions, the effective concentrations of ferrous iron (Fe2+) producing a loss of 50% of dopaminergic neurons, as quantified by tyrosine hydroxylase (TH) immunocytochemistry, TH mRNA in situ hybridization, and measurement of TH activity, were on the order of 200 microM.	Iron	95-107	tyrosine hydroxylase	Rattus norvegicus	181-201
1613493-2	1992	When cultures were switched for 24 h to serum-free conditions, the effective concentrations of ferrous iron (Fe2+) producing a loss of 50% of dopaminergic neurons, as quantified by tyrosine hydroxylase (TH) immunocytochemistry, TH mRNA in situ hybridization, and measurement of TH activity, were on the order of 200 microM.	Iron	95-107	tyrosine hydroxylase	Rattus norvegicus	203-205
1613493-2	1992	When cultures were switched for 24 h to serum-free conditions, the effective concentrations of ferrous iron (Fe2+) producing a loss of 50% of dopaminergic neurons, as quantified by tyrosine hydroxylase (TH) immunocytochemistry, TH mRNA in situ hybridization, and measurement of TH activity, were on the order of 200 microM.	Iron	95-107	tyrosine hydroxylase	Rattus norvegicus	228-230
1613493-2	1992	When cultures were switched for 24 h to serum-free conditions, the effective concentrations of ferrous iron (Fe2+) producing a loss of 50% of dopaminergic neurons, as quantified by tyrosine hydroxylase (TH) immunocytochemistry, TH mRNA in situ hybridization, and measurement of TH activity, were on the order of 200 microM.	Iron	95-107	tyrosine hydroxylase	Rattus norvegicus	228-230
1599931-1	1992	Examination was made of CO binding reactions to four kinds of modified sperm whale myoglobin (Mb), whose heme was reconstituted by iron complexes of synthetic porphyrins such as porphine (Por), meso-tetramethylporphyrin (TMeP), meso-tetraethylporphyrin (TEtP) and meso-tetra(n-propyl)porphyrin (TnPrP), using flash photolysis and stopped-flow methods.	Iron	131-135	myoglobin	Physeter catodon	83-92
1584791-1	1992	The iron-responsive element-binding protein (IRE-BP) is an RNA-binding protein that regulates the expression of several mRNAs in response to availability of cellular iron.	Iron	4-8	aconitase 1	Homo sapiens	45-51
1584791-2	1992	The iron-dependent control of IRE-BP activity has been reconstituted in vitro.	Iron	4-8	aconitase 1	Homo sapiens	30-36
1584791-5	1992	Modulation of IRE-BP activity by chelatable iron is reversible and thus does not involve permanent alterations of the integrity of the protein.	Iron	44-48	aconitase 1	Homo sapiens	14-20
1308796-7	1992	Furthermore, although serum iron levels are elevated onefold in the controls under chronic anemia with respect to non-bled animals, the concentration of serum transferrin is only slightly increased; hence, the iron saturation of this protein changes from a 50% to an 80% level.	Iron	210-214	serotransferrin	Oryctolagus cuniculus	159-170
1588948-10	1992	and cellular damage compared to that of normothermic ischemic heart, and (2) myoglobin, an intracellular protein, is a source of free iron and plays a role in the reperfusion injury mediated by free radicals.	Iron	134-138	myoglobin	Rattus norvegicus	77-86
1537518-1	1992	To gain insights at the molecular level into the expression of iron-regulated genes [transferrin (Tf), transferrin receptor (TfR), and ferritin H and L subunits] in human intestinal areas relevant to iron absorption, the steady-state levels of specific messenger RNAs (mRNAs) were analyzed in gastric and duodenal samples obtained from 6 normal subjects, or 10 patients with anemia, 14 patients with untreated iron overload, and 8 patients with various gastrointestinal disorders.	Iron	63-67	transferrin receptor	Homo sapiens	103-123
1537518-1	1992	To gain insights at the molecular level into the expression of iron-regulated genes [transferrin (Tf), transferrin receptor (TfR), and ferritin H and L subunits] in human intestinal areas relevant to iron absorption, the steady-state levels of specific messenger RNAs (mRNAs) were analyzed in gastric and duodenal samples obtained from 6 normal subjects, or 10 patients with anemia, 14 patients with untreated iron overload, and 8 patients with various gastrointestinal disorders.	Iron	63-67	transferrin receptor	Homo sapiens	125-128
1413121-4	1992	The increase of the reduced form of the Fe ion may be a result of the increased rate of the glucose-6-phosphate dehydrogenase activity in cortex brain tissue of the Campbell rats.	Iron	40-42	glucose-6-phosphate dehydrogenase	Rattus norvegicus	92-125
1310028-4	1992	About one-fourth of the beta-extended chain spectral region and one-fifth of the beta-turn region (involving a total of approximately 9-13 residues) were sensitive to the oxidation state of heme iron.	Iron	195-199	HEME	Bos taurus	190-194
1310028-6	1992	The localized structural rearrangements triggered by the changes in oxidation state of heme iron are consistent with differences in the binding of heme iron to a histidine imidazole nitrogen and a methionine sulfur atom from the beta-extended chain.	Iron	92-96	HEME	Bos taurus	87-91
1310028-6	1992	The localized structural rearrangements triggered by the changes in oxidation state of heme iron are consistent with differences in the binding of heme iron to a histidine imidazole nitrogen and a methionine sulfur atom from the beta-extended chain.	Iron	92-96	HEME	Bos taurus	147-151
1310028-6	1992	The localized structural rearrangements triggered by the changes in oxidation state of heme iron are consistent with differences in the binding of heme iron to a histidine imidazole nitrogen and a methionine sulfur atom from the beta-extended chain.	Iron	152-156	HEME	Bos taurus	87-91
1310028-6	1992	The localized structural rearrangements triggered by the changes in oxidation state of heme iron are consistent with differences in the binding of heme iron to a histidine imidazole nitrogen and a methionine sulfur atom from the beta-extended chain.	Iron	152-156	HEME	Bos taurus	147-151
1730572-0	1992	Thyroid hormone and apotransferrin regulation of growth hormone secretion by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium.	Iron	110-114	gonadotropin releasing hormone receptor	Rattus norvegicus	49-63
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Iron	67-71	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Iron	67-71	gonadotropin releasing hormone receptor	Rattus norvegicus	16-18
1657933-6	1991	We suggest that at least one of the 3 histidine residues located in the rubredoxin-like center of rubrerythrin may be liganded to one iron atom of the hemerythrin-like center.	Iron	134-138	DVU3184	Desulfovibrio vulgaris str. Hildenborough	72-82
2071236-1	1991	Localization of nucleolar protein B23 in HL-60 cells under the treatment by iron chelator deferoxamine (DSF) was studied using indirect immunofluorescence.	Iron	76-80	nucleophosmin 1	Homo sapiens	34-37
1916624-7	1991	Following the 1st exercise testing, groups IDA and Lat-ID were treated by oral iron for 1-1.5 months.	Iron	79-83	linker for activation of T cells	Homo sapiens	51-54
1920537-0	1991	Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron.	Iron	91-95	myelin basic protein	Mus musculus	59-67
1920537-8	1991	Results from these studies demonstrate that oligodendrocytes and myelin are enriched in iron in both quaking and shiverer brains.	Iron	88-92	myelin basic protein	Mus musculus	113-121
1903535-0	1991	Ferritin mRNA: interactions of iron regulatory element with translational regulator protein P-90 and the effect on base-paired flanking regions.	Iron	31-35	transferrin receptor	Homo sapiens	92-96
2001452-12	1991	Therefore, iron as FeTF (not soluble iron or nonferric TF) stimulates transcription of the CEM cell PKC-beta gene.	Iron	11-15	protein kinase C beta	Homo sapiens	100-108
2001452-15	1991	These data suggest that delivery of iron by FeTF to one or more specific cellular compartments may stimulate PKC-beta gene transcription in CEM cells.	Iron	36-40	protein kinase C beta	Homo sapiens	109-117
2004025-1	1991	The transferrin receptor is a major protein found on the basolateral membranes of intestinal epithelial cells, yet its possible role in intestinal iron metabolism and also in iron absorption is unclear.	Iron	147-151	transferrin receptor	Rattus norvegicus	4-24
2004025-1	1991	The transferrin receptor is a major protein found on the basolateral membranes of intestinal epithelial cells, yet its possible role in intestinal iron metabolism and also in iron absorption is unclear.	Iron	175-179	transferrin receptor	Rattus norvegicus	4-24
2041478-5	1991	Thus, in addition to the response to the superoxide-mediated oxidative stress which depends on SoxR, two global controls regulate MnSOD expression: ArcA couples MnSOD expression to respiration, and Fur couples it to the intracellular concentration of iron.	Iron	251-255	arginine deiminase	Escherichia coli	148-152
1883640-0	1991	Transferrin receptor expression in normal and iron overloaded liver.	Iron	46-50	transferrin receptor	Homo sapiens	0-20
2046086-6	1991	Apparent rate constants of 0.0075 +/- 0.002 sec-1 and 0.0343 +/- 0.0118 sec-1 were obtained for iron dissociation from transferrin and iron mobilization into the cytosol, respectively.	Iron	96-100	serotransferrin	Oryctolagus cuniculus	119-130
2046086-7	1991	Iron dissociation from transferrin is the rate-limiting step.	Iron	0-4	serotransferrin	Oryctolagus cuniculus	23-34
2046086-10	1991	These data indicate that the uptake of iron in reticulocytes is a sequential process, with steps after the internalization of Fe2(III)-transferrin that are distinct from the handling of transferrin.	Iron	39-43	serotransferrin	Oryctolagus cuniculus	135-146
2025345-2	1991	Iron transport crossing the cell membrane is mediated by the specific transferrin receptor (TR).	Iron	0-4	transferrin receptor	Homo sapiens	70-90
2025345-2	1991	Iron transport crossing the cell membrane is mediated by the specific transferrin receptor (TR).	Iron	0-4	transferrin receptor	Homo sapiens	92-94
2268267-9	1990	It is proposed that aluminium, when bound to transferrin, inhibits iron uptake partly by down-regulating transferrin-receptor expression and partly by interfering with intracellular release of iron from transferrin.	Iron	67-71	transferrin receptor	Homo sapiens	105-125
1701143-1	1990	The interaction of ferritin mRNA is regulated by iron via the interaction of a cytoplasmic binding protein (IRE-BP) with a specific stem-loop structure in the 5" untranslated region (UTR), referred to as the iron-responsive element (IRE).	Iron	49-53	aconitase 1	Homo sapiens	108-114
1701143-1	1990	The interaction of ferritin mRNA is regulated by iron via the interaction of a cytoplasmic binding protein (IRE-BP) with a specific stem-loop structure in the 5" untranslated region (UTR), referred to as the iron-responsive element (IRE).	Iron	208-212	aconitase 1	Homo sapiens	108-114
2173718-5	1990	generation under basal conditions and during hyperoxia, and provide iron catalysts necessary for hydroxyl radical (.OH) formation and propagation of lipid peroxidation, we postulated that cytochrome P-450 might have a potential role in mediating ischemia-reperfusion injury.	Iron	68-72	cytochrome P-450	Oryctolagus cuniculus	188-204
2176837-2	1990	Resonance Raman spectra of the purified sample revealed that the heme iron adopts the pure pentacoordinated ferric high-spin state on the basis of the nu 10 (1629cm-1) and nu 3 (1490 cm-1) mode frequencies, which are higher than those of the hexacoordinated ferric high-spin cytochrome P-450scc-substrate complexes.	Iron	70-74	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	275-294
2393721-1	1990	Data are presented indicating that the growth of 5 out of 5 murine lymphoid tumors can be inhibited in a synergistic fashion in vitro by combined treatment with the iron chelator deferoxamine (DFO) and an immunoglobulin G (IgG) monoclonal anti-transferrin receptor antibody (ATRA).	Iron	165-169	transferrin receptor	Mus musculus	244-264
2401848-9	1990	Our studies show that transferrin receptor release from HL60 cells changes during iron excess or iron deficiency and that these changes are the result of alterations in cell surface transferrin receptor density.	Iron	82-86	transferrin receptor	Homo sapiens	22-42
2367662-3	1990	In vivo experiments indicated that an intravenous dose of 5-10 mg of iron per kilogram of body weight suppressed P-31 signal from normal liver in healthy rats.	Iron	69-73	ATPase H+ transporting V1 subunit E1	Rattus norvegicus	113-117
2373683-0	1990	Resonance Raman studies of iron spin and axial coordination in distal pocket mutants of ferric myoglobin.	Iron	27-31	myoglobin	Physeter catodon	95-104
2303447-2	1990	Incubation of human erythrocytes oxidized by iron catalysts, ADP/Fe3+ or xanthine/xanthine oxidase/Fe3+, with autologous IgG resulted in IgG binding as detected by enzyme immunoassay using protein A-beta-galactosidase conjugate.	Iron	45-49	galactosidase beta 1	Homo sapiens	199-217
9994078-0	1990	Synchrotron-radiation study of Fe 3d states in Cd1-xFexSe (0 &lt;= x &lt;= 0.4).	Iron	31-33	CD1c molecule	Homo sapiens	47-50
2386528-0	1990	The regulation of transferrin receptor and glutathione peroxidase mRNAs synthesis by changes in intracellular iron levels.	Iron	110-114	transferrin receptor	Mus musculus	18-38
2386528-2	1990	Raising the levels of intracellular iron by treatment of Friend 707 cells with either hemin, Fe-pyridoxal isonicotinoyl hydrazone (PIH) or diferric transferrin (Tf) resulted in decreased levels of the labeled TfR mRNA.	Iron	36-40	transferrin receptor	Mus musculus	209-212
2128422-5	1990	These findings indicate that the reduction of iron uptake caused by the toxin is due to inhibition of the internalization of surface-located transferrin-transferrin receptor complexes, perhaps due to a disruption of cytoskeleton integrity.	Iron	46-50	serotransferrin	Oryctolagus cuniculus	141-152
2128422-5	1990	These findings indicate that the reduction of iron uptake caused by the toxin is due to inhibition of the internalization of surface-located transferrin-transferrin receptor complexes, perhaps due to a disruption of cytoskeleton integrity.	Iron	46-50	serotransferrin	Oryctolagus cuniculus	153-164
6032503-8	1967	The results are considered compatible with the concept that uptake of iron, especially at acidic pH, interferes with the formation or function of penicillinase repressor.	Iron	70-74	penicillinase repressor	Staphylococcus aureus	146-169
33821487-8	2021	It summarises the excess-iron-induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K/AKT, MAPK, p53, AMPK/MFF/DRP1 and Wnt.	Iron	25-29	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	149-153
33804129-4	2021	We found that the highest binding interactions were found with the spike protein (6VYB), with the highest overall binding being observed with Mn-bound Methisazone at -8.3 kcal/mol, followed by Zn and Ca at -8.0 kcal/mol, and Fe and Mg at -7.9 kcal/mol.	Iron	225-227	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	67-72
32795936-4	2020	Perturbation of mitochondrial ISCs biogenesis, either by depleting iron with the iron chelator or by knocking down the core components of the mitochondrial ISCs assembly machinery, triggers FUNDC1-dependent mitophagy.	Iron	67-71	FUN14 domain containing 1	Homo sapiens	190-196
32795936-4	2020	Perturbation of mitochondrial ISCs biogenesis, either by depleting iron with the iron chelator or by knocking down the core components of the mitochondrial ISCs assembly machinery, triggers FUNDC1-dependent mitophagy.	Iron	81-85	FUN14 domain containing 1	Homo sapiens	190-196
32795936-5	2020	IRP1, one of the cellular iron sensors to maintain iron homeostasis, is crucial for iron stresses induced mitophagy.	Iron	26-30	aconitase 1	Homo sapiens	0-4
32795936-5	2020	IRP1, one of the cellular iron sensors to maintain iron homeostasis, is crucial for iron stresses induced mitophagy.	Iron	51-55	aconitase 1	Homo sapiens	0-4
32795936-5	2020	IRP1, one of the cellular iron sensors to maintain iron homeostasis, is crucial for iron stresses induced mitophagy.	Iron	51-55	aconitase 1	Homo sapiens	0-4
32795936-6	2020	Knockdown of IRP1 disturbed iron stresses induced mitophagy.	Iron	28-32	aconitase 1	Homo sapiens	13-17
32795936-9	2020	Alterations of the IRP1/Bcl-xL axis navigate iron stresses induced mitophagy.	Iron	45-49	aconitase 1	Homo sapiens	19-23
14623105-1	2003	The Fet3 protein in Saccharomyces cerevisiae and mammalian ceruloplasmin are multicopper oxidases (MCO) that are required for iron homeostasis via their catalysis of the ferroxidase reaction, 4Fe(2+)+O(2)+4H(+)--&gt;4Fe(3+)+2H(2)O.	Iron	126-130	ferroxidase FET3	Saccharomyces cerevisiae S288C	4-8
34953963-5	2022	Taken together, our data suggest that activation of VDR could inhibit the phosphorylations of Tau possibly by repressing the iron accumulation-induced upregulation of GSK3beta activity in the brains of APP/PS1 mice.	Iron	125-129	glycogen synthase kinase 3 alpha	Mus musculus	167-175
34931842-0	2022	Paramagnetic 7Li NMR Shifts and Magnetic Properties of Divalent Transition Metal Silylamide Ate Complexes (LiM{N(SiMe3)2}3) (M2+ = Mn, Fe, Co).	Iron	135-137	PDZ and LIM domain 5	Homo sapiens	107-110
34930785-7	2022	Docking simulation indicated that, in the formation of M1 and M2, there would be hydrogen bonding and/or electrostatic interactions between the pyrimidine and sulfonamide moieties of DS-1971a and amino acid residues Ser100, Ile102, Ile106, Thr107, and Asn217 in CYP2C8, and that the cyclohexane ring of DS-1971a would be located near the heme iron of CYP2C8.	Iron	343-347	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	351-357
34960080-4	2021	In the present study, using a well-established rat model of fetal-neonatal ID, we demonstrated that ID downregulated hippocampal expression of the gene encoding JmjC-ARID domain-containing protein 1B (JARID1B), an iron-dependent histone H3K4 demethylase, associated with a higher histone deacetylase 1 (HDAC1) enrichment and a lower enrichment of acetylated histone H3K9 (H3K9ac) and phosphorylated cAMP response element-binding protein (pCREB).	Iron	214-218	histone deacetylase 1	Rattus norvegicus	280-301
34960080-4	2021	In the present study, using a well-established rat model of fetal-neonatal ID, we demonstrated that ID downregulated hippocampal expression of the gene encoding JmjC-ARID domain-containing protein 1B (JARID1B), an iron-dependent histone H3K4 demethylase, associated with a higher histone deacetylase 1 (HDAC1) enrichment and a lower enrichment of acetylated histone H3K9 (H3K9ac) and phosphorylated cAMP response element-binding protein (pCREB).	Iron	214-218	histone deacetylase 1	Rattus norvegicus	303-308
34843649-5	2021	Crystallographic studies with the JmjC demethylase KDM5B revealed active site binding but without direct metal chelation; however, molecular modeling investigations indicated that the inhibitors bind to MINA53 by directly interacting with the iron cofactor.	Iron	243-247	lysine demethylase 5B	Homo sapiens	51-56
34862739-1	2022	Human transferrin receptor 1 (TfR) is necessary for delivery of the iron carrier protein transferrin into cells and can be utilized for targeted delivery across cellular membranes.	Iron	68-72	transferrin receptor	Homo sapiens	6-28
34862739-1	2022	Human transferrin receptor 1 (TfR) is necessary for delivery of the iron carrier protein transferrin into cells and can be utilized for targeted delivery across cellular membranes.	Iron	68-72	transferrin receptor	Homo sapiens	30-33
34862739-2	2022	Binding of transferrin to the receptor is regulated by hereditary hemochromatosis protein (HFE), an iron regulatory protein that partly shares a binding site with transferrin on TfR.	Iron	100-104	homeostatic iron regulator	Homo sapiens	55-89
34862739-2	2022	Binding of transferrin to the receptor is regulated by hereditary hemochromatosis protein (HFE), an iron regulatory protein that partly shares a binding site with transferrin on TfR.	Iron	100-104	homeostatic iron regulator	Homo sapiens	91-94
34862739-2	2022	Binding of transferrin to the receptor is regulated by hereditary hemochromatosis protein (HFE), an iron regulatory protein that partly shares a binding site with transferrin on TfR.	Iron	100-104	transferrin receptor	Homo sapiens	178-181
34232987-4	2021	Burkitt CYB561A3 knockout induced profound iron starvation, despite ferritinophagy and plasma membrane transferrin upregulation.	Iron	43-47	cytochrome b561 family member A3	Homo sapiens	8-16
34232987-5	2021	Elevated concentrations of ascorbic acid, a key CYB561 family electron donor or the labile iron source ferrous citrate rescued Burkitt CYB561A3 deficiency.	Iron	91-95	cytochrome b561 family member A3	Homo sapiens	135-143
34175430-8	2021	Genes associated with intracellular iron metabolism and homeostasis, such as transferrin receptor 1, divalent metal transporter 1, and ferroportin-1, and showed abnormal expression levels in animal tissues and lung epithelial MLE-12 cells, which responded to BLM stimulation.	Iron	36-40	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	101-129
34369274-11	2021	Iron uptake mediated the activation of NADPH oxidase 1 (NOX1) signaling, which induced the release of reactive oxygen species (ROS) and mitochondrial damage.	Iron	0-4	NADPH oxidase 1	Homo sapiens	39-54
34369274-11	2021	Iron uptake mediated the activation of NADPH oxidase 1 (NOX1) signaling, which induced the release of reactive oxygen species (ROS) and mitochondrial damage.	Iron	0-4	NADPH oxidase 1	Homo sapiens	56-60
34612525-3	2021	In this study, it is shown that the restraint of iron availability through blocking CD71-mediated iron endocytosis impaired the differentiation and pathogenicity of TH 17 cells.	Iron	49-53	transferrin receptor	Homo sapiens	84-88
34547407-0	2021	Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic beta-cells.	Iron	115-119	inhibitor of DNA binding 1, HLH protein	Homo sapiens	69-72
34547407-12	2021	Our findings suggest that HMOX1, ID1 and ID3 define the response mechanism against iron-overload-induced stress in beta-cells.	Iron	83-87	inhibitor of DNA binding 1, HLH protein	Homo sapiens	33-36
34340090-3	2021	Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT.	Iron	101-105	ferritin 4	Arabidopsis thaliana	19-24
34848347-6	2022	Intriguingly, CIPK3/9/26 interact with and phosphorylate the tonoplast-localized Mn and iron (Fe) transporter MTP8 primarily at Ser35, which is conserved among MTP8 proteins from various species.	Iron	88-92	CBL-interacting protein kinase 3	Arabidopsis thaliana	14-24
34848347-6	2022	Intriguingly, CIPK3/9/26 interact with and phosphorylate the tonoplast-localized Mn and iron (Fe) transporter MTP8 primarily at Ser35, which is conserved among MTP8 proteins from various species.	Iron	94-96	CBL-interacting protein kinase 3	Arabidopsis thaliana	14-24
34901629-0	2021	Dealkalization and Leaching Behavior of Fe, Al, Ca, and Si of Red Mud by Waste Acid from Titanium White Production.	Iron	40-42	adaptor related protein complex 5 subunit mu 1	Homo sapiens	66-69
34944579-2	2021	The precise physiological function of FXN is still unclear; however, there is experimental evidence that the protein is involved in biosynthetic iron-sulfur cluster machinery, redox imbalance, and iron homeostasis.	Iron	145-149	frataxin	Homo sapiens	38-41
34944579-2	2021	The precise physiological function of FXN is still unclear; however, there is experimental evidence that the protein is involved in biosynthetic iron-sulfur cluster machinery, redox imbalance, and iron homeostasis.	Iron	197-201	frataxin	Homo sapiens	38-41
34824233-5	2021	Growth synergy occurs uniquely under malnourished conditions limited in protein and iron: in this context, Bacteroidales spp.	Iron	84-88	histocompatibility minor 13	Homo sapiens	121-124
34723508-4	2021	The strongest antibacterial activity of rRAr-1 was contributed by a combination of  OH and Fe(IV) generated from structural Fe(II)/adsorbed Fe2+ and soluble Fe2+, respectively.	Iron	91-93	natural cytotoxicity triggering receptor 1	Rattus norvegicus	40-46
34776018-6	2021	The results show that FE supplementation can effectively alleviate the decrease of thymus index induced by aging, decrease the escape latency of MWM by 66.06%, brain MDA by 28.04%, hippocampus GABABR1 expression by 7.98%, and increase brain SOD by 63.54% in aging model rats.	Iron	22-24	gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus	193-200
34732689-0	2021	GSK-3beta manipulates ferroptosis sensitivity by dominating iron homeostasis.	Iron	60-64	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	43-47	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	129-133	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	187-191	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
34732689-7	2021	Taken together, our findings elaborate an indispensable role of GSK-3beta in determining ferroptotic sensitivity by dominating cellular iron metabolism, which provides further insight into GSK-3beta as a target for cancer chemotherapy.	Iron	136-140	glycogen synthase kinase 3 alpha	Homo sapiens	64-73
34732689-7	2021	Taken together, our findings elaborate an indispensable role of GSK-3beta in determining ferroptotic sensitivity by dominating cellular iron metabolism, which provides further insight into GSK-3beta as a target for cancer chemotherapy.	Iron	136-140	glycogen synthase kinase 3 alpha	Homo sapiens	189-198
34498366-5	2021	The as-prepared Cu-S 1 N 3 /Cu x composite presents a 100% Faradaic efficiency towards CO generation (FE CO ) at -0.65 V vs. RHE and high FE CO over 90% from -0.55 to -0.75 V, outperforming the analogue with a Cu-N 4 coordination sphere (FE CO only 54% at -0.7 V).	Iron	102-104	cut like homeobox 1	Homo sapiens	28-32
34498366-5	2021	The as-prepared Cu-S 1 N 3 /Cu x composite presents a 100% Faradaic efficiency towards CO generation (FE CO ) at -0.65 V vs. RHE and high FE CO over 90% from -0.55 to -0.75 V, outperforming the analogue with a Cu-N 4 coordination sphere (FE CO only 54% at -0.7 V).	Iron	138-140	cut like homeobox 1	Homo sapiens	28-32
34716241-6	2021	The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis.	Iron	122-126	transferrin receptor	Mus musculus	71-75
34716241-6	2021	The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis.	Iron	122-126	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	77-81
34765600-3	2021	Yes-associated protein (YAP) controls intracellular iron levels by affecting the transcription of ferritin heavy chain (FTH) and transferrin receptor (TFRC).	Iron	52-56	Yes1 associated transcriptional regulator	Homo sapiens	0-22
34765600-3	2021	Yes-associated protein (YAP) controls intracellular iron levels by affecting the transcription of ferritin heavy chain (FTH) and transferrin receptor (TFRC).	Iron	52-56	Yes1 associated transcriptional regulator	Homo sapiens	24-27
34765600-3	2021	Yes-associated protein (YAP) controls intracellular iron levels by affecting the transcription of ferritin heavy chain (FTH) and transferrin receptor (TFRC).	Iron	52-56	transferrin receptor	Homo sapiens	129-149
34765600-3	2021	Yes-associated protein (YAP) controls intracellular iron levels by affecting the transcription of ferritin heavy chain (FTH) and transferrin receptor (TFRC).	Iron	52-56	transferrin receptor	Homo sapiens	151-155
34765600-4	2021	However, whether YAP regulates iron metabolism through other target genes remains unknown.	Iron	31-35	Yes1 associated transcriptional regulator	Homo sapiens	17-20
34831070-8	2021	Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis.	Iron	12-16	microRNA 130a	Homo sapiens	119-127
34265052-0	2021	CD63 is Regulated by Iron via the IRE-IRP System and is Important for Ferritin Secretion by Extracellular Vesicles.	Iron	21-25	Wnt family member 2	Homo sapiens	38-41
34265052-6	2021	Iron metabolism-associated proteins, such as ferritin, are intricately regulated by cellular iron levels via the iron responsive element (IRE)-iron regulatory protein (IRP) system.	Iron	0-4	Wnt family member 2	Homo sapiens	168-171
34265052-6	2021	Iron metabolism-associated proteins, such as ferritin, are intricately regulated by cellular iron levels via the iron responsive element (IRE)-iron regulatory protein (IRP) system.	Iron	93-97	Wnt family member 2	Homo sapiens	168-171
34265052-6	2021	Iron metabolism-associated proteins, such as ferritin, are intricately regulated by cellular iron levels via the iron responsive element (IRE)-iron regulatory protein (IRP) system.	Iron	113-117	Wnt family member 2	Homo sapiens	168-171
34265052-6	2021	Iron metabolism-associated proteins, such as ferritin, are intricately regulated by cellular iron levels via the iron responsive element (IRE)-iron regulatory protein (IRP) system.	Iron	143-147	Wnt family member 2	Homo sapiens	168-171
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	27-31	transferrin receptor	Homo sapiens	103-123
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	27-31	transferrin receptor	Homo sapiens	125-129
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	49-53	transferrin receptor	Homo sapiens	103-123
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	49-53	transferrin receptor	Homo sapiens	125-129
34679704-5	2021	Moreover, CS induces iron accumulation in the mitochondria and cytosol, resulting in programmed cell death.	Iron	21-25	citrate synthase	Homo sapiens	10-12
34679704-8	2021	This review outlines recent studies exploring CS-mediated iron metabolism and ROS production, along with the regulation of programmed cell death in COPD.	Iron	58-62	citrate synthase	Homo sapiens	46-48
34245812-2	2021	The acute induction of LCN2 evolved as a beneficial process, aimed at combating bacterial infection through the sequestration of iron from pathogens, while the role of LCN2 during chronic, non-infectious disease remains unclear, and recent studies suggest that LCN2 is neurotoxic.	Iron	129-133	lipocalin 2	Mus musculus	23-27
34453614-6	2021	We further show that the extra electron in the (2Fe-2S)+ clusters of one of the NEET proteins (mNT) is localized on the His-bound iron ion, consistently with our previous spectroscopic studies.	Iron	130-134	max binding protein	Mus musculus	95-98
34597301-0	2021	Cattle management in an Iron Age/Roman settlement in the Netherlands: Archaeozoological and stable isotope analysis.	Iron	24-28	renin binding protein	Bos taurus	29-32
34597301-1	2021	Cattle were the predominant domestic animal in the Iron Age and Roman Netherlands, yet their management is still incompletely understood.	Iron	51-55	renin binding protein	Bos taurus	56-59
34597301-3	2021	This paper is the first to investigate these aspects for the Iron Age and Roman Netherlands, through a case study of the site of Houten-Castellum.	Iron	61-65	renin binding protein	Bos taurus	66-69
34597301-7	2021	While our data set is small and results must therefore be interpreted cautiously, there is convincing evidence for an extended birth season in the Middle Iron Age, as well as the use of fodder.	Iron	154-158	renin binding protein	Bos taurus	159-162
34583348-7	2021	A cross-sectional study was conducted to determine the association between plasma levels of free heme, HO-1, Hp, Hx, and malaria status in pregnant women who received routine iron supplementation and their birth outcomes.	Iron	175-179	hemopexin	Homo sapiens	113-115
34547719-8	2021	Subsequently, excessive iron led to oxidative stress and impaired mitochondrial function that further led to glucose metabolism disorder and reduced ATP production by regulating the expression of key enzyme genes or proteins including G6Pase, Pck1, and Cs.	Iron	24-28	glucose-6-phosphatase, catalytic	Mus musculus	235-241
34778750-7	2021	Further analysis showed that expression of PYE, the negative regulator for Fe homeostasis, and its downstream target NAS4 were significantly altered in the double mutant.	Iron	75-77	nicotianamine synthase 4	Arabidopsis thaliana	117-121
34329004-6	2021	In addition, the reduction rates for iron and chromium could be increased with increasing CaF2 from 6.7 to 9.0 wt%.	Iron	37-41	CCR4-NOT transcription complex subunit 8	Homo sapiens	90-94
34646383-10	2021	The deletion of PDK1 in Treg cells destroyed the iron ion balance through regulating MEK-ERK signaling and CD71 expression, resulting in excessive production of intracellular ROS, which did not depend on the down-regulation of mTORC1 signaling.	Iron	49-53	midkine	Mus musculus	85-88
34646383-10	2021	The deletion of PDK1 in Treg cells destroyed the iron ion balance through regulating MEK-ERK signaling and CD71 expression, resulting in excessive production of intracellular ROS, which did not depend on the down-regulation of mTORC1 signaling.	Iron	49-53	transferrin receptor	Mus musculus	107-111
34572542-1	2021	Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis.	Iron	97-101	aconitase 1	Homo sapiens	20-24
34572542-5	2021	In turn, this is regulated by the iron-sensitive conformational equilibrium between cytosolic aconitase and IRP1, mediated by the presence of an iron-sulfur cluster.	Iron	34-38	aconitase 1	Homo sapiens	108-112
34572542-5	2021	In turn, this is regulated by the iron-sensitive conformational equilibrium between cytosolic aconitase and IRP1, mediated by the presence of an iron-sulfur cluster.	Iron	145-149	aconitase 1	Homo sapiens	108-112
34622149-1	2021	FeRIC (Ferritin iron Redistribution to Ion Channels) is a magnetogenetic technique that uses radiofrequency (RF) alternating magnetic fields to activate the transient receptor potential channels, TRPV1 and TRPV4, coupled to cellular ferritins.	Iron	16-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	196-201
34622149-1	2021	FeRIC (Ferritin iron Redistribution to Ion Channels) is a magnetogenetic technique that uses radiofrequency (RF) alternating magnetic fields to activate the transient receptor potential channels, TRPV1 and TRPV4, coupled to cellular ferritins.	Iron	16-20	transient receptor potential cation channel subfamily V member 4	Homo sapiens	206-211
34497268-5	2021	Moreover, knockdown of CISD3 significantly accelerates lipid peroxidation and accentuates free iron accumulation triggered by Xc- inhibition or cystine-deprivation, thus causing ferroptotic cell death.	Iron	95-99	CDGSH iron sulfur domain 3	Homo sapiens	23-28
34480710-8	2022	The decreased levels of TfR1 and the upregulation of FPN1 and FTH proteins observed in the LIRA-treated db/db group were shown to reduce iron overload in the hippocampus, whereas the increased expression of Mtft and decreased expression of Mfrn in the mitochondria indicated that mitochondrial iron overload was ameliorated.	Iron	137-141	transferrin receptor	Mus musculus	24-28
34298093-5	2021	Crosstalk between non-heme catalytic iron/Nox4 and downstream oxidative damage generated a mutual amplification cycle that facilitated rapid progression of cisplatin-induced iAKI.	Iron	37-41	NADPH oxidase 4	Homo sapiens	42-46
34298093-7	2021	Heme-iron induced lipid peroxidation and DNA oxidation by interacting with Nox4-independent mechanisms, promoting p53/p21 activity and cellular senescence.	Iron	5-9	NADPH oxidase 4	Homo sapiens	75-79
34087581-12	2021	Moreover, deferoxamine, an iron chelator, also inhibited CIN, with a decrease in the expression of COX-2 and 4-HNE.	Iron	27-31	cytochrome c oxidase II, mitochondrial	Mus musculus	99-104
34158342-3	2021	The transferrin receptor 1 (TfR1), also known as CD71, is important for iron uptake and regulation of cellular proliferation.	Iron	72-76	transferrin receptor	Homo sapiens	28-32
34158342-3	2021	The transferrin receptor 1 (TfR1), also known as CD71, is important for iron uptake and regulation of cellular proliferation.	Iron	72-76	transferrin receptor	Homo sapiens	49-53
34462321-5	2021	We also uncovered a paralogous synthetic lethal mechanism behind a genetic interaction between STAG2 and the iron regulatory gene IREB2 Finally, investigation of an unusually strong context-dependent genetic interaction in HAP1 cells revealed factors that could be important for alleviating cohesin loading stress.	Iron	109-113	stromal antigen 2	Homo sapiens	95-100
34452626-0	2021	Efficacy and cost-effectiveness of universal pre-operative iron studies in total hip and knee arthroplasty.	Iron	59-63	hedgehog interacting protein	Homo sapiens	81-84
34452919-3	2021	We identified a redox homeostasis network containing the iron-sulfur cluster enzyme, NFS1.	Iron	57-61	NFS1 cysteine desulfurase	Homo sapiens	85-89
34452919-5	2021	Suppression of CAIX activity acidified intracellular pH, increased cellular reactive oxygen species accumulation, and induced susceptibility to alterations in iron homeostasis.	Iron	159-163	carbonic anhydrase 9	Homo sapiens	15-19
34173816-3	2021	This study proposed to investigate the effect of Ilex paraguariensis infusion on the absorption of non-heme iron in hereditary hemochromatosis (HH) patients with the HFE genotype.	Iron	108-112	homeostatic iron regulator	Homo sapiens	166-169
34389031-12	2021	Further experiments showed that TFRC, the primary receptor for transferrin-mediated iron uptake, was overexpressed on HCC cells but not TAM.	Iron	84-88	transferrin receptor	Mus musculus	32-36
34389031-17	2021	CONCLUSIONS: Collectively, we identified iron starvation through TFRC-mediated iron competition drives functional immunosuppressive polarization of TAM, providing new insight into the interconnection between iron metabolism and tumor immunity.	Iron	41-45	transferrin receptor	Homo sapiens	65-69
34389031-17	2021	CONCLUSIONS: Collectively, we identified iron starvation through TFRC-mediated iron competition drives functional immunosuppressive polarization of TAM, providing new insight into the interconnection between iron metabolism and tumor immunity.	Iron	79-83	transferrin receptor	Homo sapiens	65-69
34613168-8	2021	While doping GaN with Fe or Si elements, the introduced free carriers modify the electronic interband transition.	Iron	22-24	gigaxonin	Homo sapiens	13-16
34361537-0	2021	The Correlation Analysis of Microstructure and Tribological Characteristics of In Situ VCp Reinforced Iron-Based Composite.	Iron	102-106	valosin containing protein	Homo sapiens	87-90
34361537-1	2021	In this study, four kinds of heat treatments were performed to obtain a certain amount of retained austenite, which can result in good toughness and low brittleness accompanied with wear resistance of an in situ VC particle reinforced iron-based composite (VCFC).	Iron	235-239	valosin containing protein	Homo sapiens	212-214
34334787-2	2021	Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2; LCN2 the murine homolog) is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.	Iron	116-120	lipocalin 2	Mus musculus	0-42
34334787-2	2021	Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2; LCN2 the murine homolog) is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.	Iron	116-120	lipocalin 2	Mus musculus	52-63
34334787-2	2021	Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2; LCN2 the murine homolog) is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.	Iron	116-120	lipocalin 2	Mus musculus	65-69
34362147-12	2021	We propose that this correlation may be related to increased hematopoietic stress, increased consumption of nitric oxide (NO) by hemolysis, and the inhibitory effects of iron supplements on osteogenesis through the receptor activator of nuclear factor kappaB ligand (RANKL)/Osteoprotegerin pathway and the Runt-related transcription factor 2 (RUNX2) factor.	Iron	170-174	TNF receptor superfamily member 11b	Homo sapiens	274-289
34444760-10	2021	CONCLUSION: Our findings show the protective effects of total dietary iron, especially nonheme iron, against GC risk, and this association can be modified by TFRC rs9846149.	Iron	70-74	transferrin receptor	Homo sapiens	158-162
34444760-10	2021	CONCLUSION: Our findings show the protective effects of total dietary iron, especially nonheme iron, against GC risk, and this association can be modified by TFRC rs9846149.	Iron	95-99	transferrin receptor	Homo sapiens	158-162
34442352-5	2021	The mutation of this gene causes a deficiency of frataxin, which induces an altered inflow of iron into the mitochondria, increasing the nervous system"s vulnerability to oxidative stress.	Iron	94-98	frataxin	Homo sapiens	49-57
34083449-2	2021	We found that the catalytic subunit of the RdRp, nsp12, ligates two iron-sulfur metal cofactors in sites that were modeled as zinc centers in the available cryo-electron microscopy structures of the RdRp complex.	Iron	68-72	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	43-47
34083449-2	2021	We found that the catalytic subunit of the RdRp, nsp12, ligates two iron-sulfur metal cofactors in sites that were modeled as zinc centers in the available cryo-electron microscopy structures of the RdRp complex.	Iron	68-72	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	199-203
34083449-5	2021	These iron-sulfur clusters thus serve as cofactors for the SARS-CoV-2 RdRp and are targets for therapy of COVID-19.	Iron	6-10	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	70-74
34281233-6	2021	Iron chelator-induced apoptosis was due to the activation of the MAPK signaling pathway, with increased phosphorylation levels of JNK, p38 and ERK, and ROS generation; in this process, the expression of C-caspase-3 and C-PARP increased.	Iron	0-4	mitogen-activated protein kinase 14	Mus musculus	135-138
34077792-5	2021	Two types of transferrin receptors (TfRs), TfR1 and TfR2, are known to play a role in iron uptake in erythroid cells.	Iron	86-90	transferrin receptor	Homo sapiens	43-47
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	165-169	aconitase 1	Homo sapiens	23-55
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	165-169	aconitase 1	Homo sapiens	57-61
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	199-203	aconitase 1	Homo sapiens	23-55
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	199-203	aconitase 1	Homo sapiens	57-61
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	283-287	aconitase 1	Homo sapiens	23-55
34389108-4	2021	At the cellular level, iron regulatory proteins 1 and 2 (IRP1 and IRP2) register cytosolic iron concentrations and post-transcriptionally regulate the expression of iron metabolism genes to optimize iron availability for essential cellular processes, including heme biosynthesis and iron-sulfur cluster biogenesis.	Iron	283-287	aconitase 1	Homo sapiens	57-61
34238411-3	2021	Results The weight gain percentages of mice in the negative control, low-, medium-, and high-dose iron groups were 25.47%, 25.22%, 24.74%, and 21.36%, respectively, which was significantly lower in the high-dose group than in the negative control(F=17.235, P=0.027), low-dose(F=15.206, P=0.031), and medium-dose(F=11.061, P=0.036)groups.Liver had the highest iron content, followed by spleen, kidney, and small intestine.The iron content in heart and lung tissues of the low-dose group had no significant difference compared with those of the negative control group(F=19.023, P=0.715;F=23.193, P=0.902).Serum iron and ferritin in the iron-overloaded mice increased in a dose-dependent manner, while transferrin and transferrin receptor had no significant changes.HE and Prussian blue staining showed that the iron-overloaded mice had different degrees of iron deposition in tissues and high-dose iron caused liver and kidney damage.The lung(F=23.227, P=0.017), spleen(F=19.023, P=0.021), and liver(F=17.392, P=0.009)of the iron-overloaded mice with TB had a significantly shorter time of bacterial culture than those of the TB-infected mice without iron overload.The lung(F=21.012, P=0.007), spleen(F=20.173, P=0.002), and liver(F=19.091, P=0.005)of the iron-overloaded mice with TB had significantly higher bacterial loads than those of the TB-infected mice without iron overload.	Iron	98-102	transferrin receptor	Mus musculus	715-735
34167528-2	2021	This research aim was to evaluate the effectiveness of the PRECEDE model nutrition education on iron deficiency anemia among female students of Fasa City, Fars Province, Iran.	Iron	96-100	FASA	Homo sapiens	144-148
34161397-8	2021	Thus, treatment of cells with excess iron inhibited basal and BMP6-mediated SMAD5 phosphorylation and induction of HAMP, ID1 and SMAD7 mRNAs in a dose-dependent manner.	Iron	37-41	inhibitor of DNA binding 1, HLH protein	Homo sapiens	121-124
34161397-9	2021	Iron also inhibited IL-6-mediated STAT3 phosphorylation and induction of HAMP and SOCS3 mRNAs.	Iron	0-4	suppressor of cytokine signaling 3	Homo sapiens	82-87
34211444-7	2021	Our work thus suggests that the ancestors of extant iron-oxidizers were the first to evolve COX.	Iron	52-56	cytochrome c oxidase subunit 8A	Homo sapiens	92-95
34200842-5	2021	In the next step, participation of FexAly fraction was increased through the annealing process, with three temperature values, 700  C, 800  C, and 900  C. Phase structure evolution of the Fe-Al arc-sprayed coating, stimulated by annealing, has been described by means of SEM images taken with a QBSD backscattered electron detector and by XRD and conversion electron Mossbauer spectroscopy (CEMS) investigations.	Iron	188-190	activity regulated cytoskeleton associated protein	Homo sapiens	194-197
34199378-0	2021	Molecular Details of the Frataxin-Scaffold Interaction during Mitochondrial Fe-S Cluster Assembly.	Iron	76-80	frataxin	Homo sapiens	25-33
34199378-2	2021	Although there are three different Fe-S cluster assembly pathways in prokaryotes (the NIF, SUF and ISC pathways) and two in eukaryotes (CIA and ISC pathways), the iron-sulfur cluster (ISC) pathway serves as the central mechanism for providing 2Fe-2S clusters, directly and indirectly, throughout the entire cell in eukaryotes.	Iron	35-39	S100 calcium binding protein A8	Homo sapiens	86-89
34199378-6	2021	These details support a complex dynamic interaction between the FXN and ISCU proteins when both are part of the NIAUF complex and this provides additional insight into the coordinated mechanism of Fe-S cluster assembly.	Iron	197-199	frataxin	Homo sapiens	64-67
34927885-4	2021	Herein, a facile way of preparing bimetallic Fe and Co sites entrapped in nitrogen-doped hollow carbon nanospheres (Fe,Co-SA/CS) is explored, drawing on the unique structure and pore characteristics of Zeolitic imidazole frameworks and molecular size of Ferrocene, an Fe containing species.	Iron	45-47	citrate synthase	Homo sapiens	125-127
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	109-111	DNA polymerase iota	Homo sapiens	112-116
35304229-9	2022	Upon SN iron chelation, transferrin receptor (Tfr) expression was found to be upregulated.	Iron	8-12	transferrin receptor	Mus musculus	24-44
35304229-9	2022	Upon SN iron chelation, transferrin receptor (Tfr) expression was found to be upregulated.	Iron	8-12	transferrin receptor	Mus musculus	46-49
35147903-6	2022	However, Cp deficiency affected the expression of many iron metabolism-related proteins in midbrain, such as DMT1+IRE, heavy chain ferritin (H-ferritin) and light chain ferritin (L-ferritin).	Iron	55-59	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	109-113
35603634-4	2022	Momelotinib is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of hepcidin expression and increased availability of iron for erythropoiesis.	Iron	145-149	Janus kinase 2	Homo sapiens	22-26
35582962-7	2022	Moreover, FA effectively inhibited iron accumulation and alleviated ferroptosis in the Achilles tendon.	Iron	35-39	glycogen synthase kinase 3 beta	Rattus norvegicus	10-12
35582962-8	2022	Using in vitro experiments, we found that FA antagonized ferroptosis by reducing lipid peroxidation and iron accumulation in tenocytes.	Iron	104-108	glycogen synthase kinase 3 beta	Rattus norvegicus	42-44
35061889-5	2022	Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption.	Iron	86-90	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	101-133
35061889-5	2022	Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption.	Iron	86-90	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	135-139
35061889-5	2022	Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption.	Iron	195-199	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	101-133
35061889-5	2022	Here, we hypothesized that certain AA would increase abundance of the main intestinal iron importer, divalent metal-ion transporter 1 (DMT1), on the BBM of duodenal enterocytes, thus stimulating iron absorption.	Iron	195-199	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	135-139
35061889-9	2022	In iron-deprived mice, oral intragastric administration of the 4AA formulation increased DMT1 protein abundance on the enterocyte BBM (by ~1.5-fold; p<0.05).	Iron	3-7	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	89-93
35567766-3	2022	We aimed to determine whether common genetic variants influencing iron levels or liver disease risk in the general population also modify clinical penetrance in HFE p.C282Y and p.H63D carriers.	Iron	66-70	homeostatic iron regulator	Homo sapiens	161-164
35567766-11	2022	CONCLUSIONS: HFE p.C282Y homozygote penetrance to clinical disease in a large community cohort was partly explained by common genetic variants that influence iron and risks of related diagnoses in the general population.	Iron	158-162	homeostatic iron regulator	Homo sapiens	13-16
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	Iron	197-201	fibroblast growth factor receptor 4	Homo sapiens	24-29
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	Iron	197-201	transcription factor 4	Homo sapiens	124-128
35562334-6	2022	Ferroptosis, a unique iron-dependent form of oxidative cell death, is triggered after FGFR4 inhibition.	Iron	22-26	fibroblast growth factor receptor 4	Homo sapiens	86-91
35465672-0	2022	Morphology-Dependent Electrocatalytic Performance of a Two-Dimensional Nickel-Iron MOF for Oxygen Evolution Reaction.	Iron	78-82	lysine acetyltransferase 8	Homo sapiens	83-86
35522475-2	2022	Herein, PdFe 1 single-atom alloy metallene, in which the Fe single atoms are confined on Pd metallene support, is first developed as an effective and robust NRR electro catalyst, delivering the exceptional NRR performance with an NH 3 yield of 111.9 mug h -1 mg -1 , a Faradaic efficiency of 37.8 % at -0.2 V (RHE) , as well as a long-term stability for 100 h electrolysis .	Iron	57-59	factor interacting with PAPOLA and CPSF1	Homo sapiens	310-313
35499081-6	2022	The subsequent loss of BDH2 drove labile iron to accumulate in the cytoplasm and promoted TET enzyme activity, BCL6 gene demethylation, and Tfh cell differentiation.	Iron	41-45	3-hydroxybutyrate dehydrogenase, type 2	Mus musculus	23-27
35499082-8	2022	We demonstrated that the miR-21/BDH2 axis drove iron accumulation during Tfh cell differentiation and further promoted Fe2+-dependent TET enzyme activity and BCL6 gene demethylation.	Iron	48-52	microRNA 21a	Mus musculus	25-31
35499082-8	2022	We demonstrated that the miR-21/BDH2 axis drove iron accumulation during Tfh cell differentiation and further promoted Fe2+-dependent TET enzyme activity and BCL6 gene demethylation.	Iron	48-52	3-hydroxybutyrate dehydrogenase, type 2	Mus musculus	32-36
35608094-2	2022	This labile Fe-N bond led to multiple unfolding/rupture pathways of mNT and its cluster by atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS), one of most common tools for characterizing the molecular mechanics.	Iron	12-14	max binding protein	Mus musculus	68-71
35124415-10	2022	Inhibiting miR-21 reduced intracellular iron accumulation and DNA hydroxymethylation in T cells.	Iron	40-44	microRNA 21a	Mus musculus	11-17
35124415-11	2022	In conclusion, inhibiting miR-21 in vivo improves intracellular iron homeostasis and inhibits Tfh cell overexpansion, contributing to reduced autoimmune responses and the remission of disease symptoms in murine lupus.	Iron	64-68	microRNA 21a	Mus musculus	26-32
35183003-2	2022	The as-synthesized MIL-101(Fe) was characterized by XRD, FE-SEM, FTIR, TGA and zeta potential techniques, and then employed as an adsorbent for methyl orange (MO) and methylene blue (MB) dyes.	Iron	27-29	T-box transcription factor 1	Homo sapiens	71-74
35487958-3	2022	Limiting phosphate and iron in growth media induced expression of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein from the P. tricornutum HASP1 promoter in the wild-type strain and in a histidine auxotrophic strain that alleviates the requirement for antibiotic selection of expression plasmids.	Iron	23-27	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	118-123
35571998-0	2022	Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory.	Iron	93-97	catechol-O-methyltransferase	Homo sapiens	21-49
35571998-3	2022	We investigated the effect of COMT Val 158 Met (rs4680), a polymorphism crucial for dopamine degradation and proxy for endogenous dopamine, on iron accumulation and working memory in a longitudinal lifespan sample (n = 208, age 20-79 at baseline, mean follow-up time = 2.75 years) using structural equation modelling.	Iron	143-147	catechol-O-methyltransferase	Homo sapiens	30-34
35472140-9	2022	RESULTS: We confirmed the well-known roles of CB2 and TRPV1 receptors in bone metabolism and suggested that their stimulation can reduce the OC overactivity induced by iron, providing new insights into the pathogenesis of pediatric IBD-related bone resorption.	Iron	168-172	transient receptor potential cation channel subfamily V member 1	Homo sapiens	54-59
35472140-10	2022	CONCLUSIONS: Stimulation of CB2 and TRPV1 could reduce IBD-related osteoporosis due to their direct effects on OC activity and to modulating the iron metabolism.	Iron	145-149	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-41
35624697-1	2022	The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf.	Iron	63-67	transferrin receptor	Homo sapiens	4-26
35624697-1	2022	The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf.	Iron	63-67	transferrin receptor	Homo sapiens	28-32
35624697-1	2022	The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf.	Iron	104-108	transferrin receptor	Homo sapiens	4-26
35624697-1	2022	The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf.	Iron	104-108	transferrin receptor	Homo sapiens	28-32
35624697-7	2022	Further pharmacological research showed that 12b bound to Transferrin receptor 1 (TfR1) directly caused iron deprivation and ROS imbalance along with the degradations of several oncoproteins, especially FGFR1, through the proteasome pathway; thus, inducing cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells.	Iron	104-108	transferrin receptor	Homo sapiens	58-80
35624697-7	2022	Further pharmacological research showed that 12b bound to Transferrin receptor 1 (TfR1) directly caused iron deprivation and ROS imbalance along with the degradations of several oncoproteins, especially FGFR1, through the proteasome pathway; thus, inducing cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells.	Iron	104-108	transferrin receptor	Homo sapiens	82-86
35472330-1	2022	Friedreich"s Ataxia (FRDA) is a degenerative disease caused by a decrease in the mitochondrial protein frataxin, which is involved in iron-sulfur cluster (ISC) synthesis.	Iron	134-138	frataxin	Homo sapiens	21-25
35472330-1	2022	Friedreich"s Ataxia (FRDA) is a degenerative disease caused by a decrease in the mitochondrial protein frataxin, which is involved in iron-sulfur cluster (ISC) synthesis.	Iron	134-138	frataxin	Homo sapiens	103-111
35472330-2	2022	Diminutions in frataxin result in decreased ISC synthesis, increased mitochondrial iron accumulation, and impaired mitochondrial function.	Iron	83-87	frataxin	Homo sapiens	15-23
35472330-4	2022	We demonstrate that the mitochondrial Lon protease is involved in frataxin degradation and that iron export through the mitochondrial metal transporter Mmt1 protects yeast frataxin from degradation.	Iron	96-100	Mmt1p	Saccharomyces cerevisiae S288C	152-156
35472330-4	2022	We demonstrate that the mitochondrial Lon protease is involved in frataxin degradation and that iron export through the mitochondrial metal transporter Mmt1 protects yeast frataxin from degradation.	Iron	96-100	frataxin	Homo sapiens	172-180
35472330-5	2022	We also determined that when FRDA fibroblasts were grown in media containing elevated iron, mitochondrial ROS increased and frataxin decreased compared to WT fibroblasts.	Iron	86-90	frataxin	Homo sapiens	29-33
35472330-5	2022	We also determined that when FRDA fibroblasts were grown in media containing elevated iron, mitochondrial ROS increased and frataxin decreased compared to WT fibroblasts.	Iron	86-90	frataxin	Homo sapiens	124-132
34990508-0	2022	Modulation of the HIF2-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis.	Iron	60-64	nuclear receptor coactivator 4	Mus musculus	23-28
34990508-5	2022	Nuclear receptor co-activator 4 (NCOA4) is a critical cargo receptor for autophagic breakdown of ferritin (FTN) and subsequent release of iron, in a process termed ferritinophagy.	Iron	138-142	nuclear receptor coactivator 4	Mus musculus	0-31
34990508-5	2022	Nuclear receptor co-activator 4 (NCOA4) is a critical cargo receptor for autophagic breakdown of ferritin (FTN) and subsequent release of iron, in a process termed ferritinophagy.	Iron	138-142	nuclear receptor coactivator 4	Mus musculus	33-38
34990508-6	2022	Our work demonstrates that NCOA4-mediated intestinal ferritinophagy is integrated to systemic iron demand via HIF2a.	Iron	94-98	nuclear receptor coactivator 4	Mus musculus	27-32
34990508-10	2022	Therefore, NCOA4 can be selectively targeted for the management of iron overload disorders without disrupting the physiological processes involved in the response to systemic iron deficiency.	Iron	67-71	nuclear receptor coactivator 4	Mus musculus	11-16
35440572-1	2022	Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse cellular processes including cell death/survival, inflammation, iron delivery and cell differentiation.	Iron	152-156	lipocalin 2	Mus musculus	33-44
35440572-1	2022	Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse cellular processes including cell death/survival, inflammation, iron delivery and cell differentiation.	Iron	152-156	lipocalin 2	Mus musculus	46-50
35602653-2	2022	Intracellular iron homeostasis in mammals is maintained by two homologous ubiquitously expressed iron-responsive element-binding proteins (IRP1 and IRP2).	Iron	14-18	aconitase 1	Homo sapiens	139-143
35602653-2	2022	Intracellular iron homeostasis in mammals is maintained by two homologous ubiquitously expressed iron-responsive element-binding proteins (IRP1 and IRP2).	Iron	97-101	aconitase 1	Homo sapiens	139-143
35396375-6	2022	Moreover, iron chelation of HU is also indispensable for inducing cell stress, and MMP2 is the support factor to protect cells from death.	Iron	10-14	matrix metallopeptidase 2	Homo sapiens	83-87
35448720-6	2022	In comparison, 18F-fluoroestradiol (18F-FES) is a novel estrogen-receptor-specific PET radiotracer, which more accurately assesses the intracranial and intraorbital compartments in patients with estrogen-receptor-positive (ER+) cancers than 18F-FDG, due to lack of physiologic background activity in these regions.	Iron	40-43	epiregulin	Homo sapiens	223-225
35060269-4	2022	While highly selective, the strategy is applicable for proteins expressed as inclusion bodies, and this was showcased by the efficient semi-synthesis of an iron-sulfur protein-rubredoxin and the catalytic and hinge domains of matrix metalloprotease-14 (MMP-14) containing 207 amino acid residues.	Iron	156-160	matrix metallopeptidase 14	Homo sapiens	226-251
35060269-4	2022	While highly selective, the strategy is applicable for proteins expressed as inclusion bodies, and this was showcased by the efficient semi-synthesis of an iron-sulfur protein-rubredoxin and the catalytic and hinge domains of matrix metalloprotease-14 (MMP-14) containing 207 amino acid residues.	Iron	156-160	matrix metallopeptidase 14	Homo sapiens	253-259
34981858-0	2022	BCAS3-Related Neurodevelopmental Disorder Shows Magnetic Resonance Imaging Features Resembling Brain Iron Accumulation.	Iron	101-105	BCAS3 microtubule associated cell migration factor	Homo sapiens	0-5
35338344-7	2022	The knockdown of TfR1 and treatment with an inhibitor of FGFR2 caused significant impairment in iron uptake and suppression of cellular proliferation in vitro.	Iron	96-100	transferrin receptor	Homo sapiens	17-21
35089637-7	2022	Knockdown of PCBP2 but not PCBP1 significantly decreased both TfR1 and FTH expression in MM cells with inhibition of proliferation, indicating stagnation of intracellular iron transport.	Iron	171-175	transferrin receptor	Rattus norvegicus	62-66
35092867-1	2022	In beta-thalassemia, free alpha-globin chains are unstable and tend to aggregate or degrade, releasing toxic heme, porphyrins and iron, which produce reactive oxygen species (ROS).	Iron	130-134	hemoglobin subunit alpha 2	Homo sapiens	26-38
35401208-8	2022	In addition, we observed that the levels of both iron and anti-acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) were significantly increased in the spinal cord after SNI, while the expression of glutathione peroxidase 4 (GPX4) was decreased.	Iron	49-53	glutathione peroxidase 4	Rattus norvegicus	208-232
35401208-8	2022	In addition, we observed that the levels of both iron and anti-acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) were significantly increased in the spinal cord after SNI, while the expression of glutathione peroxidase 4 (GPX4) was decreased.	Iron	49-53	glutathione peroxidase 4	Rattus norvegicus	234-238
35045264-4	2022	Herein, we observe modulation of the transferrin receptor (TfR) during infection and a corresponding change in the cellular labile iron pool.	Iron	131-135	transferrin receptor	Homo sapiens	37-57
35045264-4	2022	Herein, we observe modulation of the transferrin receptor (TfR) during infection and a corresponding change in the cellular labile iron pool.	Iron	131-135	transferrin receptor	Homo sapiens	59-62
35319371-6	2022	RESULTS: In this study, we demonstrated that cerebral ischemia induced iron-deposition, down-regulated dramatically the expression of the glutathione peroxidase 4 (GPX4), decreased the expression of the nuclear receptor coactivator 4 (NCOA4) and induced inappropriate accumulation of ferritin in the ischemic brain.	Iron	71-75	nuclear receptor coactivator 4	Mus musculus	235-240
35299258-2	2022	The peroxidase (POD) like activity of Fe@BC nanozyme was studied and utilized for detecting the activity of alanine aminotransferase (ALT).	Iron	38-40	glutamic--pyruvic transaminase	Homo sapiens	108-132
35063709-6	2022	Under this premise, a tumor-specific catalytic nanomedicine for enhanced tumor ablation accompanied with tumor vasculature disruption and new angiogenesis inhibition was developed through a cascade reaction with glucose oxidase modified on the surface of iron-based metal organic framework coupled with VEGFR2 antibody.	Iron	255-259	kinase insert domain protein receptor	Mus musculus	303-309
35051814-2	2022	Degradation experiment results showed bimetallic catalyst Cu-Fe@CS can degrade more FA than monometallic catalysts (Cu@CS and Fe@CS) due to the synergistic effect between the copper and iron.	Iron	61-63	citrate synthase	Homo sapiens	64-66
35051814-2	2022	Degradation experiment results showed bimetallic catalyst Cu-Fe@CS can degrade more FA than monometallic catalysts (Cu@CS and Fe@CS) due to the synergistic effect between the copper and iron.	Iron	61-63	citrate synthase	Homo sapiens	119-121
35051814-2	2022	Degradation experiment results showed bimetallic catalyst Cu-Fe@CS can degrade more FA than monometallic catalysts (Cu@CS and Fe@CS) due to the synergistic effect between the copper and iron.	Iron	61-63	citrate synthase	Homo sapiens	129-131
35051814-2	2022	Degradation experiment results showed bimetallic catalyst Cu-Fe@CS can degrade more FA than monometallic catalysts (Cu@CS and Fe@CS) due to the synergistic effect between the copper and iron.	Iron	186-190	citrate synthase	Homo sapiens	64-66
35051814-2	2022	Degradation experiment results showed bimetallic catalyst Cu-Fe@CS can degrade more FA than monometallic catalysts (Cu@CS and Fe@CS) due to the synergistic effect between the copper and iron.	Iron	186-190	citrate synthase	Homo sapiens	119-121
35051814-2	2022	Degradation experiment results showed bimetallic catalyst Cu-Fe@CS can degrade more FA than monometallic catalysts (Cu@CS and Fe@CS) due to the synergistic effect between the copper and iron.	Iron	186-190	citrate synthase	Homo sapiens	129-131
35359834-0	2022	Iron Promotes Cardiac Doxorubicin Retention and Toxicity Through Downregulation of the Mitochondrial Exporter ABCB8.	Iron	0-4	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	110-115
35359834-4	2022	Here, we hypothesized that iron stores influence cardiac ABCB8 expression and consequently cardiac retention and toxicity of DOX.	Iron	27-31	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	57-62
35359834-8	2022	Western blot and qPCR analyses revealed that ABCB8 levels were decreased in iron overload and increased in iron deficiency.	Iron	76-80	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	45-50
35359834-14	2022	Together, our results demonstrate that ABCB8 mediates DOX efflux and that iron regulates DOX retention and toxicity by altering cardiac ABCB8 expression.	Iron	74-78	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	136-141
35310092-5	2022	At the cellular level, FRDA is characterized by a general deficit in the biosynthesis of iron-sulfur (Fe-S) clusters and heme, iron accumulation and deposition in mitochondria, and sensitivity to oxidative stress.	Iron	127-131	frataxin	Homo sapiens	23-27
35310092-6	2022	Based on these phenotypes and the proposed ability of FXN to bind iron, a role as an iron storage protein providing iron for Fe-S cluster and heme biosynthesis was initially proposed.	Iron	66-70	frataxin	Homo sapiens	54-57
35310092-6	2022	Based on these phenotypes and the proposed ability of FXN to bind iron, a role as an iron storage protein providing iron for Fe-S cluster and heme biosynthesis was initially proposed.	Iron	85-89	frataxin	Homo sapiens	54-57
35310092-6	2022	Based on these phenotypes and the proposed ability of FXN to bind iron, a role as an iron storage protein providing iron for Fe-S cluster and heme biosynthesis was initially proposed.	Iron	116-120	frataxin	Homo sapiens	54-57
35310092-6	2022	Based on these phenotypes and the proposed ability of FXN to bind iron, a role as an iron storage protein providing iron for Fe-S cluster and heme biosynthesis was initially proposed.	Iron	125-127	frataxin	Homo sapiens	54-57
35310092-7	2022	However, this model was challenged by several other studies and it is now widely accepted that FXN functions primarily in Fe-S cluster biosynthesis, with iron accumulation, heme deficiency and oxidative stress sensitivity appearing later on as secondary defects.	Iron	122-124	frataxin	Homo sapiens	95-98
35310092-7	2022	However, this model was challenged by several other studies and it is now widely accepted that FXN functions primarily in Fe-S cluster biosynthesis, with iron accumulation, heme deficiency and oxidative stress sensitivity appearing later on as secondary defects.	Iron	154-158	frataxin	Homo sapiens	95-98
35310092-8	2022	Nonetheless, the biochemical function of FXN in Fe-S cluster biosynthesis is still debated.	Iron	48-52	frataxin	Homo sapiens	41-44
35310092-9	2022	Several roles have been proposed for FXN: iron chaperone, gate-keeper of detrimental Fe-S cluster biosynthesis, sulfide production stimulator and sulfur transfer accelerator.	Iron	42-46	frataxin	Homo sapiens	37-40
35310092-9	2022	Several roles have been proposed for FXN: iron chaperone, gate-keeper of detrimental Fe-S cluster biosynthesis, sulfide production stimulator and sulfur transfer accelerator.	Iron	85-89	frataxin	Homo sapiens	37-40
35310092-10	2022	A picture is now emerging which points toward a unique function of FXN as an accelerator of a key step of sulfur transfer between two components of the Fe-S cluster biosynthetic complex.	Iron	152-154	frataxin	Homo sapiens	67-70
35386310-4	2022	Ferritin, an iron storage protein, traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1 (TfR1) overexpressed on BBB endothelial cells.	Iron	13-17	transferrin receptor	Homo sapiens	102-124
35386310-4	2022	Ferritin, an iron storage protein, traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1 (TfR1) overexpressed on BBB endothelial cells.	Iron	13-17	transferrin receptor	Homo sapiens	126-130
35229267-4	2022	Elemental mapping of individual element on Pe-FeLs clearly indicated the existing of iron.	Iron	85-89	plasmalemma vesicle associated protein	Homo sapiens	46-50
35229267-5	2022	The XRD pattern showed the amorphous hydroxides of iron on Pe-FeLs.	Iron	51-55	plasmalemma vesicle associated protein	Homo sapiens	62-66
35038358-0	2022	Drosophila ZIP13 overexpression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria.	Iron	115-119	Transferrin 1	Drosophila melanogaster	35-47
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	Transferrin 1	Drosophila melanogaster	381-393
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	Transferrin 1	Drosophila melanogaster	395-399
35221331-3	2022	However, the influence and regulation of cysteine desulfurase (NFS1), a rate-limiting enzyme in iron-sulfur (Fe-S) cluster biogenesis, in colorectal cancer (CRC) remain elusive.	Iron	109-113	NFS1 cysteine desulfurase	Homo sapiens	63-67
35270089-0	2022	Impacts of Mn, Fe, and Oxidative Stressors on MnSOD Activation by AtMTM1 and AtMTM2 in Arabidopsis.	Iron	15-17	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	66-72
35270089-4	2022	In addition, it has been reported that E. coli MnSOD activity is inhibited by Fe and that MTM1-mutated yeast cells exhibit elevated Fe content and decreased MnSOD activity, which can be restored by the Fe2+-specific chelator, bathophenanthroline disulfonate (BPS).	Iron	132-134	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	90-94
35270089-5	2022	However, we showed that BPS inhibited MnSOD activity in AtMTM1 and AtMTM2 single- and double-mutant protoplasts, implying that altered Fe homeostasis affected MnSOD activation through AtMTM1 and AtMTM2.	Iron	135-137	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	184-190
35270089-6	2022	Notably, we used inductively coupled plasma-optical emission spectrometry (ICP-OES) analysis to reveal an abnormal Fe/Mn ratio in the roots and shoots of AtMTM1 and AtMTM2 mutants under MV stress, indicating the importance of AtMTM1 in roots and AtMTM2 in shoots for maintaining Fe/Mn balance.	Iron	279-281	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	154-160
35133148-6	2022	These results suggest that iron overload may promote the progress of the chronic liver disease by activating cGAS-STING-mediated chronic inflammation, which provides a new idea for the development of drugs for the treatment of the chronic liver disease.	Iron	27-31	stimulator of interferon response cGAMP interactor 1	Homo sapiens	114-119
35080470-3	2022	In a Phase I clinical trial, an investigational meningococcal OMV vaccine, MenPF1, made from a meningococcus genetically modified to constitutively express the iron-regulated FetA induced bactericidal responses to both the PorA and the FetA antigen present in the OMP.	Iron	160-164	ATPase phospholipid transporting 8B5, pseudogene	Homo sapiens	175-179
35080470-3	2022	In a Phase I clinical trial, an investigational meningococcal OMV vaccine, MenPF1, made from a meningococcus genetically modified to constitutively express the iron-regulated FetA induced bactericidal responses to both the PorA and the FetA antigen present in the OMP.	Iron	160-164	ATPase phospholipid transporting 8B5, pseudogene	Homo sapiens	236-240
35164549-9	2022	IMPORTANCE Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form one of the few known redox systems in the apicoplast of malaria parasites and provide reducing power to iron-sulfur (FeS) cluster proteins within the organelle.	Iron	186-189	ferredoxin reductase	Homo sapiens	31-57
35203634-3	2022	In this review, we explore the paradigmatic example of frataxin, an iron binding protein involved in Fe-S cluster biogenesis, and whose impairment causes a neurodegenerative disease called Friedreich"s Ataxia (FRDA).	Iron	68-72	frataxin	Homo sapiens	55-63
35203634-3	2022	In this review, we explore the paradigmatic example of frataxin, an iron binding protein involved in Fe-S cluster biogenesis, and whose impairment causes a neurodegenerative disease called Friedreich"s Ataxia (FRDA).	Iron	101-105	frataxin	Homo sapiens	55-63
35223999-0	2022	Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans.	Iron	46-50	Beta-Carotene 15,15'-MonoOxygenase	Caenorhabditis elegans	59-65
35136051-11	2022	Furthermore, mitochondrial iron accumulation led to generation of LPS-induced ROS, a process blocked by NL-1 or shRNA.	Iron	27-31	neuroligin 1	Homo sapiens	104-108
35218933-5	2022	mRNA decay assays indicate that the mRNA-binding protein Pub1 contributes to RP transcript stabilization during adaptation to iron limitation.	Iron	126-130	Pub1p	Saccharomyces cerevisiae S288C	57-61
35218933-6	2022	In fact, Pub1 becomes critical for growth and translational repression in low-iron conditions.	Iron	78-82	Pub1p	Saccharomyces cerevisiae S288C	9-13
35008011-6	2022	The results of potentiodynamic polarization demonstrated that HAp/GO/Ag coating has the lowest corrosion current density (0.31 muA/cm2), maximum protection efficiency (90.0%), and lowest release of Fe, Cr, and Ni ions (31, 24, and 15 ppb).	Iron	198-200	reticulon 3	Homo sapiens	62-65
35019917-2	2022	It exhibited an excellent selective and sensitive CHEF-based recognition of trivalent metal ions M3+ (M = Fe, Al and Cr) over mono and di-valent and other trivalent metal ions with prominent enhancement in the absorption and fluorescence intensity for Fe3+ (669-fold), Al3+ (653-fold) and Cr3+ (667-fold) upon the addition of 2.6 equivalent of these metal ions in the probe in H2O/CH3CN (7 : 3, v/v, pH 7.2).	Iron	106-108	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	289-292
35079622-7	2022	Iron was excessively accumulated in ISCU-deficient skeletal muscle, which was accompanied by a downregulation of IRP1 and mitoferrin2 genes and an upregulation of frataxin (FXN) gene expression.	Iron	0-4	aconitase 1	Homo sapiens	113-117
35079622-7	2022	Iron was excessively accumulated in ISCU-deficient skeletal muscle, which was accompanied by a downregulation of IRP1 and mitoferrin2 genes and an upregulation of frataxin (FXN) gene expression.	Iron	0-4	frataxin	Homo sapiens	163-171
35079622-7	2022	Iron was excessively accumulated in ISCU-deficient skeletal muscle, which was accompanied by a downregulation of IRP1 and mitoferrin2 genes and an upregulation of frataxin (FXN) gene expression.	Iron	0-4	frataxin	Homo sapiens	173-176
35118074-7	2021	This study verified that the iron metabolism-related gene signature (SLC39A8 and SLC48A1) could be used as a prognostic biomarker for patients with COAD.	Iron	29-33	solute carrier family 39 member 8	Homo sapiens	69-76
35174317-4	2022	MYCN increases iron metabolism and subsequent hydroxyl radicals through increased expression of the transferrin receptor 1 (TfR1) and low levels of the ferroportin receptor.	Iron	15-19	transferrin receptor	Homo sapiens	100-122
35174317-4	2022	MYCN increases iron metabolism and subsequent hydroxyl radicals through increased expression of the transferrin receptor 1 (TfR1) and low levels of the ferroportin receptor.	Iron	15-19	transferrin receptor	Homo sapiens	124-128
34914818-6	2022	The modification of Sn vacancies and Fe, Co atoms not only expands the visible light response range of the SnS2/graphene heterojunction, but also introduces magnetism, which is expected to be applied in spin optoelectronic materials.	Iron	37-39	sodium voltage-gated channel alpha subunit 11	Homo sapiens	107-111
35417944-7	2022	The uniform distribution of the transmembrane glycoprotein CD71 in the of substantia nigra structures both in the control and in PD patients indicates the preservation of non-heme iron transport during the neurodegenerative process.	Iron	180-184	transferrin receptor	Homo sapiens	59-63
35125723-2	2022	Possible genes which may be implicated in causing iron overload are hepcidin (HAMP) and hemojuvelin (HFE).	Iron	50-54	homeostatic iron regulator	Homo sapiens	101-104
35125723-3	2022	There is variable data assessing the role of c.-582Y A > G HAMP gene and H63D hotspot in HFE-1 gene in causing iron overload, while role of HFE-2 gene is undetermined.	Iron	111-115	homeostatic iron regulator	Homo sapiens	89-94
35368484-1	2022	Background: The elevated serum iron levels and reduced platelet count at 20-24th week of gestation period cause oxidative stress that leads to the pregnancy-induced hypertension (PIH).	Iron	31-35	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	179-182
35368484-12	2022	The risk of developing PIH is 6.76 times due to increased serum iron levels and 3.67 due to decreased platelet count.	Iron	64-68	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	23-26
35368484-13	2022	Conclusion: The serum iron levels were elevated, and the platelet indices were reduced in the PIH group.	Iron	22-26	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	94-97
2558579-0	1989	Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn.	Iron	0-2	lactotransferrin	Bos taurus	39-50
2558579-0	1989	Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn.	Iron	103-105	lactotransferrin	Bos taurus	39-50
2558579-1	1989	We have previously characterized a brush-border membrane receptor that facilitates iron uptake from human lactoferrin.	Iron	83-87	lactotransferrin	Bos taurus	106-117
2558579-3	1989	In this study, iron uptake from lactoferrin fragments was studied, as well as from lactoferrin partially saturated with iron.	Iron	15-19	lactotransferrin	Bos taurus	32-43
2558579-4	1989	Brush-border membrane vesicles (BBMV) prepared from infant rhesus monkey small intestine efficiently accumulated iron from lactoferrin half-molecules, although competition experiments showed that intact lactoferrin has a higher affinity toward the receptor.	Iron	113-117	lactotransferrin	Bos taurus	123-134
2558579-4	1989	Brush-border membrane vesicles (BBMV) prepared from infant rhesus monkey small intestine efficiently accumulated iron from lactoferrin half-molecules, although competition experiments showed that intact lactoferrin has a higher affinity toward the receptor.	Iron	113-117	lactotransferrin	Bos taurus	203-214
2558579-5	1989	Lactoferrin partially saturated with iron also effectively delivered iron to the receptor, whereas the affinity was lower than for lactoferrin saturated with iron.	Iron	37-41	lactotransferrin	Bos taurus	0-11
2558579-5	1989	Lactoferrin partially saturated with iron also effectively delivered iron to the receptor, whereas the affinity was lower than for lactoferrin saturated with iron.	Iron	69-73	lactotransferrin	Bos taurus	0-11
2558579-5	1989	Lactoferrin partially saturated with iron also effectively delivered iron to the receptor, whereas the affinity was lower than for lactoferrin saturated with iron.	Iron	69-73	lactotransferrin	Bos taurus	0-11
2558579-6	1989	Lactoferrin also carries a large proportion of human milk manganese, and receptor-mediated uptake of lactoferrin-bound manganese into BBMV was demonstrated, although this complex had lower affinity than that found for iron-lactoferrin.	Iron	218-222	lactotransferrin	Bos taurus	0-11
2558579-6	1989	Lactoferrin also carries a large proportion of human milk manganese, and receptor-mediated uptake of lactoferrin-bound manganese into BBMV was demonstrated, although this complex had lower affinity than that found for iron-lactoferrin.	Iron	218-222	lactotransferrin	Bos taurus	101-112
2558579-6	1989	Lactoferrin also carries a large proportion of human milk manganese, and receptor-mediated uptake of lactoferrin-bound manganese into BBMV was demonstrated, although this complex had lower affinity than that found for iron-lactoferrin.	Iron	218-222	lactotransferrin	Bos taurus	223-234
2558579-7	1989	Thus, although the receptor has a preference for intact iron-saturated lactoferrin, partially digested lactoferrin and partially iron-saturated lactoferrin can also deliver iron to the receptor.	Iron	56-60	lactotransferrin	Bos taurus	71-82
2696433-6	1989	As lactoferrin is an iron binding protein three test formulas were used: (a) no added iron and no added lactoferrin (basic), (b) no iron but added lactoferrin (L), and (c) added iron and lactoferrin (LF).	Iron	21-25	lactotransferrin	Bos taurus	3-14
2484575-4	1989	Ferritin isolated from soybean (Glycina max), horse spleen, and rat liver bound the metal ions in amounts larger than predicted from their iron core.	Iron	139-143	ferritin-1, chloroplastic	Glycine max	0-8
2676228-3	1989	In addition to a small increase in intestinal cell proliferation, as reflected by increased ornithine decarboxylase activity, EGF/UGO-feeding increased mucosal permeability (evaluated with [51Cr]-EDTA): the latter could account for the increase in iron absorption.	Iron	248-252	epidermal growth factor	Mus musculus	126-129
2541717-1	1989	Both bovine myeloperoxidase and lactoperoxidase contain one calcium per iron with no other metal present in significant amount.	Iron	72-76	myeloperoxidase	Bos taurus	12-27
2541717-1	1989	Both bovine myeloperoxidase and lactoperoxidase contain one calcium per iron with no other metal present in significant amount.	Iron	72-76	lactoperoxidase	Bos taurus	32-47
2535839-5	1989	However, the extent of the superoxide scavenging of CP did not quantitatively account for its effects on iron release, suggesting that CP inhibits superoxide-dependent mobilization of ferritin iron independently of its ability to scavenge superoxide.	Iron	193-197	ceruloplasmin	Homo sapiens	135-137
2535839-8	1989	However, CP-dependent, iron-catalyzed lipid peroxidation was inhibited by the addition of apoferritin.	Iron	23-27	ceruloplasmin	Homo sapiens	9-11
2535839-8	1989	However, CP-dependent, iron-catalyzed lipid peroxidation was inhibited by the addition of apoferritin.	Iron	23-27	ferritin heavy chain 1	Homo sapiens	90-101
2535839-9	1989	Apoferritin did not function as a peroxyl radical-scavenging antioxidant but was shown to incorporate iron in the presence of CP.	Iron	102-106	ferritin heavy chain 1	Homo sapiens	0-11
2535839-10	1989	These data suggest that CP inhibits superoxide and ferritin-dependent lipid peroxidation largely via its ability to reincorporate reductively mobilized iron back into ferritin.	Iron	152-156	ceruloplasmin	Homo sapiens	24-26
2665999-12	1989	In plasma, the ferrous iron is converted into the ferric form via the action of ceruloplasmin.	Iron	23-27	ceruloplasmin	Homo sapiens	80-93
2472979-12	1989	Modifications of the side chains of the porphyrin ring at positions 2 and 4, giving mesoporphyrin IX and deuteroporphyrin IX, changed the effectiveness of the iron- and the cobalt-porphyrins to limit the AIA-induced increase in ALA synthase RNA.	Iron	159-163	5'-aminolevulinate synthase 1	Gallus gallus	228-240
3210238-2	1988	The oxygen dissociation constants from Fe subunits in the half-ligated intermediate states of Fe-Co hybrid hemoglobins, alpha(Fe-O2)2 beta(Co)2 and alpha(Co)2 beta(Fe-O2)2, have been determined as functions of pH, temperature and inositol hexaphosphate.	Iron	39-41	complement C2	Homo sapiens	120-143
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Iron	205-209	interferon gamma	Rattus norvegicus	30-40
2458347-4	1988	The molecular basis of these findings is discussed and a possible mechanism suggested where one of the molecular forms of concanavalin A has the structure of an apoferritin into which iron is deposited in the form of ferrihydrite.	Iron	184-188	ferritin heavy chain 1	Homo sapiens	161-172
3397540-5	1988	Because both NADH-DH and SDH contain numerous iron-sulfur clusters, damage to these structures may be one result of injury by activated macrophages.	Iron	46-50	aminoadipate-semialdehyde synthase	Mus musculus	25-28
3397540-12	1988	There was selective loss of 55Fe activity in the area of the gel corresponding to SDH and NADH-DH, suggesting that iron loss from iron-sulfur clusters may occur in L1210 cells injured by activated macrophages.	Iron	115-119	aminoadipate-semialdehyde synthase	Mus musculus	82-85
3379047-6	1988	These results indicate that iron OEP serves as a prosthetic group for myoglobin with normal function, despite the significant structural and electronic difference between OEP and protoporphyrin.	Iron	28-32	myoglobin	Homo sapiens	70-79
3283351-5	1988	Evidence has accumulated to suggest that uteroferrin, rather than functioning as an acid phosphatase, is involved in transporting iron to the conceptus.	Iron	130-134	acid phosphatase 5, tartrate resistant	Bos taurus	41-52
3667586-6	1987	The binding of the first 100 irons to apoferritin quenches the intrinsic fluorescence without affecting the lifetimes in a proportional way.	Iron	29-34	ferritin heavy chain 1	Homo sapiens	38-49
2827627-3	1987	study has shown that the probable iron environment in chicken ovotransferrin involves two low-Z ligands (consistent with phenolate linkages) at 0.185(1) nm and four low-Z ligands at 0.204(1) nm [Garratt, Evans, Hasnain &amp; Lindley (1986) Biochem.	Iron	34-38	transferrin (ovotransferrin)	Gallus gallus	62-76
2827627-7	1987	and near-edge structure suggestive of a decrease in the co-ordination number of ovotransferrin-bound iron upon freeze-drying.	Iron	101-105	transferrin (ovotransferrin)	Gallus gallus	80-94
2827627-11	1987	The results suggest the presence of a labile water molecule at the iron-binding sites of ovotransferrin in solution.	Iron	67-71	transferrin (ovotransferrin)	Gallus gallus	89-103
3038309-1	1987	Purified iron-saturated human lactoferrin (LF) was assessed in vivo for effects on the survival rates of C57BL X DBA/2 f1 (hereafter called BD2F1) (Fv-2sr) mice and titers of spleen focus-forming viruses (SFFV) in BD2F1 and DBA/2 (Fv-2ss) mice inoculated with the polycythemia-inducing strain of the Friend virus complex (FVC-P).	Iron	9-13	lactotransferrin	Mus musculus	30-41
3034875-1	1987	The effect of phosphate on the binuclear iron center of pink (reduced) uteroferrin was examined by magnetic resonance and optical spectroscopy.	Iron	41-45	acid phosphatase 5, tartrate resistant	Bos taurus	71-82
2958185-4	1987	Exogenous IL-2, however, restored the ability of spleen cells from iron-loaded mice to generate allo-specific cytotoxicity in bulk culture.	Iron	67-71	interleukin 2	Mus musculus	10-14
2958185-5	1987	Clonal assays for the precursor cells of cytotoxic T lymphocytes (CTL-P), performed in the presence of added IL-2, demonstrated that iron-loaded mice contained normal numbers of CTL-P.	Iron	133-137	interleukin 2	Mus musculus	109-113
2958185-6	1987	However, cultures of spleen cells from carbonyl iron-loaded mice generated less IL-2 following Concanavalin A stimulation, apparently as a result of a reduction in the number of IL-2-secreting cells amongst the spleen cell population.	Iron	48-52	interleukin 2	Mus musculus	80-84
2958185-6	1987	However, cultures of spleen cells from carbonyl iron-loaded mice generated less IL-2 following Concanavalin A stimulation, apparently as a result of a reduction in the number of IL-2-secreting cells amongst the spleen cell population.	Iron	48-52	interleukin 2	Mus musculus	178-182
3608980-1	1987	The cell-surface receptor for transferrin mediates cellular uptake of iron from serum.	Iron	70-74	CD177 molecule	Homo sapiens	4-25
3574673-5	1987	Ceruloplasmin is involved in iron metabolism, and the findings suggest that hypoceruloplasminemia due to lack of apoceruloplasmin was causally linked to the iron deposition in basal ganglia and other organs, leading to blepharospasm and retinal degeneration.	Iron	29-33	ceruloplasmin	Homo sapiens	0-13
3574673-5	1987	Ceruloplasmin is involved in iron metabolism, and the findings suggest that hypoceruloplasminemia due to lack of apoceruloplasmin was causally linked to the iron deposition in basal ganglia and other organs, leading to blepharospasm and retinal degeneration.	Iron	157-161	ceruloplasmin	Homo sapiens	0-13
3492923-0	1987	Interleukin 1-induced depression of iron and zinc: role of granulocytes and lactoferrin.	Iron	36-40	interleukin 1 alpha	Homo sapiens	0-13
3825173-5	1987	longitudinal relaxation rate measurements revealed that in the case of cytochrome P-450c, paracetamol was orientated with its phenolic hydroxyl group in closest proximity to the central haem iron ion.	Iron	191-195	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	71-88
3557273-0	1986	[Purification and characterization of lathosterol 5-desaturase from rat liver microsomes by cytochrome b5-sepharose affinity column chromatography: evidence for the non-heme iron protein].	Iron	174-178	sterol-C5-desaturase	Rattus norvegicus	38-62
3490440-9	1986	The ability to inhibit IL-2 was abrogated by passing the cells through a Sephadex G-10 column, removal of plastic adherent cells, and removal of carbonyl iron-ingesting cells.	Iron	154-158	interleukin 2	Mus musculus	23-27
3759957-0	1986	Iron incorporation into apoferritin.	Iron	0-4	ferritin heavy chain 1	Homo sapiens	24-35
3759957-7	1986	It is suggested that the described oxidation process represents the initial step of iron deposition in apoferritin.	Iron	84-88	ferritin heavy chain 1	Homo sapiens	103-114
3778666-14	1986	In contrast, these properties of Fe.HTr (ceruloplasmin) were little affected by dialysis against H2O.	Iron	33-35	ceruloplasmin	Homo sapiens	41-54
3943278-6	1986	It seems likely that apoferritin is synthesized in response to the amount of iron taken into the cell and this iron is incorporated within the protein shell to form ferritin.	Iron	77-81	ferritin heavy chain 1	Homo sapiens	21-32
3943278-6	1986	It seems likely that apoferritin is synthesized in response to the amount of iron taken into the cell and this iron is incorporated within the protein shell to form ferritin.	Iron	111-115	ferritin heavy chain 1	Homo sapiens	21-32
2416045-4	1985	Furthermore, injections of IL-1 into animals are followed by fever, leukocytosis, increased serum concentrations of fibrinogen, serum amyloid A and haptoglobin, and decreased levels of iron and zinc.	Iron	185-189	interleukin 1 alpha	Homo sapiens	27-31
2995345-11	1985	Comparison of the present data with those of myeloperoxidase has led to the conclusion that the structure of the iron center and its vicinity in spleen green hemeprotein is very similar, if not identical, to that of myeloperoxidase.	Iron	113-117	myeloperoxidase	Bos taurus	45-60
2995345-11	1985	Comparison of the present data with those of myeloperoxidase has led to the conclusion that the structure of the iron center and its vicinity in spleen green hemeprotein is very similar, if not identical, to that of myeloperoxidase.	Iron	113-117	myeloperoxidase	Bos taurus	216-231
18251103-9	1983	The ferritin iron mobilization rates decrease in the order of riboflavin &gt; FMN &gt; FAD.	Iron	13-17	formin 1	Homo sapiens	78-81
6843660-2	1983	Amino acid sequence and iron binding studies have shown that p97 is structurally and functionally related to transferrin.	Iron	24-28	melanotransferrin	Homo sapiens	61-64
6847196-3	1983	This competition may be the molecular basis for the inhibition of iron incorporation into apoferritin brought about by Tb(III).	Iron	66-70	ferritin heavy chain 1	Homo sapiens	90-101
6282878-5	1982	In contrast, only the thiolate-bound form is seen for myoglobin regardless of thiol acidity or solution pH (5.5-11.0), indicating that the heme iron of myoglobin is less electron-rich than that of P-450.	Iron	144-148	myoglobin	Homo sapiens	152-161
6282878-15	1982	The dissimilarities observed between P-450 and myoglobin in their reactivity toward sulfur donor ligands at least partly reflect the variation in heme iron electron density resulting from their different endogenous axial ligands and may, in turn, help to explain their respective physiological functions of oxygen activation and reversible oxygen binding.	Iron	151-155	myoglobin	Homo sapiens	47-56
7037371-5	1982	In addition, we compared the effects of a series of divalent cations (Cu, Zn, Mg, Ca, Fe, Ba, Sr, Mn; 2.5 mM each) on LHRH release and found that copper stimulated release seventeenfold, zinc--sixfold, and the other divalent cations--twofold or less.	Iron	86-88	gonadotropin releasing hormone 1	Rattus norvegicus	118-122
7078081-1	1982	Transferrin binds with and delivers serum iron to bone marrow where it is used in heme production.	Iron	42-46	inhibitor of carbonic anhydrase	Macaca mulatta	0-11
7079002-1	1982	Newborn rats born to iron deficient mothers (IDM) were found to have significantly lower hemoglobin, sucrase, lactase and maltase levels compared to control newborn rats.	Iron	21-25	lactase	Rattus norvegicus	110-117
7079002-9	1982	Rats born to and nursed by ISM and maintained on an iron deficient diet from day 21-84 had significantly lower hemoglobin, serum iron, sucrase, lactase and maltase levels compared to control rats.	Iron	52-56	lactase	Rattus norvegicus	144-151
7405143-1	1980	Following the 50-kilometer ski race qualified athletes showed a significant decrease in the iron plasma content and formed elements of the blood.	Iron	92-96	SKI proto-oncogene	Homo sapiens	27-30
7405144-1	1980	The biotic doses of trace elements (iron, copper, and manganese) contained by hemostimulin exert a favourable effect on working capacity of athletes, hemopoiesis, catalase and ceruloplasmin activity as well as on transferrin saturation with iron.	Iron	36-40	ceruloplasmin	Homo sapiens	176-189
6244304-1	1980	The chemical reactivity of fully maleylated horse heart cytochrome c with oxidants, reductants, and iron ligands was studied in the presence and absence of MgCl2.	Iron	100-104	cytochrome c, somatic	Equus caballus	56-68
6155856-0	1980	The role of ceruloplasmin in iron exchange between ferritin and apotransferrin in vitro [proceedings].	Iron	29-33	ceruloplasmin	Homo sapiens	12-25
443429-7	1979	Concomitant with iron transport stimulation, aryl hydrocarbon hydroxylase activity in the intestine and liver is increased by TCDD treatment.	Iron	17-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	45-73
513495-3	1979	Anephric rats receiving 2 U of erythropoietin per day for 12 days had greater than threefold more bone marrow red cell precursors and a twofold larger plasma iron turnover than did the saline injected anephric rats.	Iron	158-162	erythropoietin	Rattus norvegicus	31-45
695748-5	1978	Phenobarbitone when administered alone increased serum minerals except sodium, but to a lesser degree than CCl4, while phenobarbitone when given repeatedly together with small doses of CCl4 led to a normalization of serum iron, calcium and potassium.	Iron	222-226	C-C motif chemokine ligand 4	Homo sapiens	185-189
620821-0	1978	Stoichiometry of iron oxidation by apoferritin.	Iron	17-21	ferritin heavy chain 1	Homo sapiens	35-46
747324-6	1978	Lactoferrin and transferrin in the iron-free state were both susceptible to proteolysis, but the iron saturated forms were more resistant and tended to give rise to stable iron-binding fragments.	Iron	35-39	lactotransferrin	Bos taurus	0-11
1165251-3	1975	The proximal histidine of the globins and two adjacent helices are equivalent to the sixth iron ligand and adjacent helices of cytochrome b5.	Iron	91-95	cytochrome b5 type A	Homo sapiens	127-140
1144955-2	1975	Iron induction of apoferritin biosynthesis.	Iron	0-4	ferritin heavy chain 1	Homo sapiens	18-29
4214890-1	1974	The hyposideremia of inflammation was found to be based on a three-step mechanism involving lactoferrin, the iron-binding protein from the specific granules of neutrophilic leukocytes.	Iron	109-113	lactotransferrin	Rattus norvegicus	92-103
4214890-2	1974	(a) Lactoferrin is Released from Neutrophils in an Iron-Free Form.	Iron	51-55	lactotransferrin	Rattus norvegicus	4-15
4375972-6	1974	Polymers of cytochrome c carboxymethylated on the methionine residue normally ligated to iron show simple CO recombination kinetics after photolytic removal (k(on)=1.5x10(6)m(-1).s(-1) at pH6).	Iron	89-93	cytochrome c, somatic	Equus caballus	12-24
4375972-7	1974	We therefore suggest that, for native cytochrome c, polymerization has an effect on the lability of the haem crevice, rendering the iron available for binding ligands, without, however, forming the structure of a truly open crevice.	Iron	132-136	cytochrome c, somatic	Equus caballus	38-50
4831065-0	1974	Infrared evidence for the mode of binding of oxygen to iron of myoglobin from heart muscle.	Iron	55-59	myoglobin	Homo sapiens	63-72
4798313-2	1973	Inhibition by Zn(2+) of iron uptake by apoferritin at very low substrate concentrations is shown to be competitive.	Iron	24-28	ferritin heavy chain 1	Homo sapiens	39-50
5805400-0	1969	On the mechanism of iron-induced synthesis of apoferritin in HeLa cells.	Iron	20-24	ferritin heavy chain 1	Homo sapiens	46-57
5755405-0	1968	[Biological determination of plasmatic erythropoietin by stucy of the percent of incorporation of Fe 59 into the erythrocytes of fasting rats].	Iron	98-100	erythropoietin	Rattus norvegicus	39-53
17757730-0	1946	Iron Concentrations in Cholinesterase Preparations.	Iron	0-4	butyrylcholinesterase	Homo sapiens	23-37
20998461-0	1946	Iron concentrations in cholinesterase preparations.	Iron	0-4	butyrylcholinesterase	Homo sapiens	23-37
21001168-0	1946	Ferritin; increase of the protein apoferritin in the gastrointestinal mucosa as a direct response to iron feeding; the function of ferritin in the regulation of iron absorption.	Iron	101-105	ferritin heavy chain 1	Homo sapiens	34-45
33901579-0	2021	Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2alpha/ATF4/CHOP pathway in vitro.	Iron	0-4	DNA-damage inducible transcript 3	Mus musculus	132-136
33901579-11	2021	In conclusion, our finding suggested that iron overload induced apoptosis via eliciting ER stress, which resulted in mitochondrial dysfunction and activated p-eIF2alpha/ATF4/CHOP pathway.	Iron	42-46	DNA-damage inducible transcript 3	Mus musculus	174-178
33721635-6	2021	Furthermore, Fe-DCPD also exhibited a faster hydrolysis rate, which was up to 2.67 times that of Fe-free DCPD and accelerated Cd"s transfer to the stable host mineral, hydroxylapatite.	Iron	13-15	CDP-diacylglycerol synthase 1	Homo sapiens	126-130
33527721-1	2021	AIMS: beta-thalassemia major (beta-TM) is associated with iron overload, abnormal lipid levels and oxidative stress.	Iron	58-62	ATM serine/threonine kinase	Homo sapiens	30-37
33601106-0	2021	Synergistically coupling of Fe-doped CoP nanocubes with CoP nanosheet arrays towards enhanced and robust oxygen evolution electrocatalysis.	Iron	28-30	caspase recruitment domain family member 16	Homo sapiens	37-40
33601106-0	2021	Synergistically coupling of Fe-doped CoP nanocubes with CoP nanosheet arrays towards enhanced and robust oxygen evolution electrocatalysis.	Iron	28-30	caspase recruitment domain family member 16	Homo sapiens	56-59
33601106-2	2021	Herein, we demonstrate an interfacial engineering strategy to prepare Fe-doped CoP nanocubes/CoP nanosheet arrays heterostructure supported on carbon cloth (denoted as CoFeP/CoP/CC).	Iron	70-72	caspase recruitment domain family member 16	Homo sapiens	79-82
34031459-4	2021	Among 38 proteins previously predicted to coordinate Fe-S clusters, two proteins, HP0207 (a member of the Nbp35/ApbC ATPase family) and HP0277 (previously annotated as FdxA, a member of the YfhL ferredoxin-like family) were further studied, using a bacterial two-hybrid system approach to identify protein-protein interactions.	Iron	53-55	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	106-111
33822774-6	2021	The amelioration of responsiveness to erythropoietin resulted in reduced soluble erythroferrone, increased liver Hamp expression, and diminished liver iron overload.	Iron	151-155	erythropoietin	Mus musculus	38-52
33741464-4	2021	The molecular modeling of 19 with the X-ray crystal structure of IDO1 indicated that dipole-ionic interactions with heme iron, halogen bonding with Cys129 and the two hydrophobic interactions were important for the high potency of 19.	Iron	121-125	indoleamine 2,3-dioxygenase 1	Homo sapiens	65-69
33965601-1	2021	BACKGROUND: SARS-CoV-2 attacks hemoglobin through its structural protein ORF3a dissociating the iron from the heme since iron is necessary by the cell machinery for the virus replication.	Iron	96-100	ORF3a protein	Severe acute respiratory syndrome coronavirus 2	73-78
33965601-1	2021	BACKGROUND: SARS-CoV-2 attacks hemoglobin through its structural protein ORF3a dissociating the iron from the heme since iron is necessary by the cell machinery for the virus replication.	Iron	121-125	ORF3a protein	Severe acute respiratory syndrome coronavirus 2	73-78
33982327-2	2021	Growth factors, such as BMP2, BMP6 and TGFbeta1, are released from liver sinusoidal endothelial cells (LSECs) and signal in a paracrine manner to hepatocytes and hepatic stellate cells to control systemic iron homeostasis and fibrotic processes, respectively.	Iron	205-209	bone morphogenetic protein 6	Mus musculus	30-34
33982327-3	2021	The misregulation of the TGFbeta/BMP pathway affects expression of the iron-regulated hormone hepcidin causing frequent iron overload and deficiency diseases.	Iron	71-75	transforming growth factor alpha	Mus musculus	25-32
33982327-3	2021	The misregulation of the TGFbeta/BMP pathway affects expression of the iron-regulated hormone hepcidin causing frequent iron overload and deficiency diseases.	Iron	120-124	transforming growth factor alpha	Mus musculus	25-32
33970249-6	2021	The lesion in MAX1 was in the haem-iron ligand signature of the cytochrome P450 protein, converting the highly conserved Gly469 to Arg, which was shown in a transient expression assay to substantially inhibit activity of MAX1.	Iron	35-39	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	14-18
33970249-6	2021	The lesion in MAX1 was in the haem-iron ligand signature of the cytochrome P450 protein, converting the highly conserved Gly469 to Arg, which was shown in a transient expression assay to substantially inhibit activity of MAX1.	Iron	35-39	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	221-225
34040623-6	2021	Such studies on the nutrient interaction pathways suggest that an MYB-like transcription factor, phosphate starvation response 1 (PHR1), acts as a master regulator of N, P, S, Fe, and Zn homeostasis.	Iron	176-178	phosphate starvation response 1	Arabidopsis thaliana	97-128
34040623-6	2021	Such studies on the nutrient interaction pathways suggest that an MYB-like transcription factor, phosphate starvation response 1 (PHR1), acts as a master regulator of N, P, S, Fe, and Zn homeostasis.	Iron	176-178	phosphate starvation response 1	Arabidopsis thaliana	130-134
33843393-7	2021	Interleukin-6 levels showed no relevant inflammation.Conclusion: Our data suggest that initial high serum ferritin and hepcidin levels indicate elevated iron levels characteristic of early stages of HFrEF, without inflammation.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	119-127
33949504-3	2021	The shortest cationanion distance between the phosphorus ion of the (PPh4)+ cation and the ferric ion of the [FeIII(HATD)2]- anion is 13.190 A in complex 1, whereas that between the ferrous ion of the [FeII(Phen)3]2+ cation and the ferric ion of the [FeIII(HATD)2]- anion is 7.821 A in complex 2.	Iron	91-101	potassium two pore domain channel subfamily K member 3	Homo sapiens	69-73
33938360-1	2022	In the present study, we investigated the effect of maternal iron deficiency anaemia (IDA) on expression of the newly discovered iron transporter, Zyklopen in term placenta, in 200 pregnant women.	Iron	61-65	hephaestin-like 1	Mus musculus	147-155
33938360-11	2022	Recently a copper-containing oxidase called Zyklopen was discovered which was involved in iron efflux in BeWo cells.	Iron	90-94	hephaestin-like 1	Mus musculus	44-52
33323945-5	2021	We have previously demonstrated that the Transferrin/Transferrin Receptor 2 (TfR2) iron import mechanism functions in nigral dopaminergic neurons, is perturbed in PD models and patients, and therefore constitutes a potential therapeutic target to halt iron accumulation.	Iron	83-87	transferrin receptor 2	Homo sapiens	53-75
33323945-5	2021	We have previously demonstrated that the Transferrin/Transferrin Receptor 2 (TfR2) iron import mechanism functions in nigral dopaminergic neurons, is perturbed in PD models and patients, and therefore constitutes a potential therapeutic target to halt iron accumulation.	Iron	83-87	transferrin receptor 2	Homo sapiens	77-81
33323945-5	2021	We have previously demonstrated that the Transferrin/Transferrin Receptor 2 (TfR2) iron import mechanism functions in nigral dopaminergic neurons, is perturbed in PD models and patients, and therefore constitutes a potential therapeutic target to halt iron accumulation.	Iron	252-256	transferrin receptor 2	Homo sapiens	53-75
33323945-5	2021	We have previously demonstrated that the Transferrin/Transferrin Receptor 2 (TfR2) iron import mechanism functions in nigral dopaminergic neurons, is perturbed in PD models and patients, and therefore constitutes a potential therapeutic target to halt iron accumulation.	Iron	252-256	transferrin receptor 2	Homo sapiens	77-81
33455469-5	2021	In addition, HIF-2alpha inhibitors can be used for the treatment or prevention of iron overload disorders, Crohn"s disease, ulcerative colitis, and thyroid eye disease, or to improve muscle generation and repair.	Iron	82-86	endothelial PAS domain protein 1	Homo sapiens	13-23
34002827-0	2021	Vitamin D and iron levels correlate weakly with hepcidin levels in postoperative patients with digestive neoplasms undergoing open abdominal surgery.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	48-56
34002827-7	2021	RESULTS: We observed a negligible/weak correlation between serum iron and hepcidin levels in the first 24 hours after surgery, with a correlation coefficient of 0.24 and a weak/low correlation between hepcidin and vitamin D levels, with a correlation coefficient of 0.37.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	74-82
34002827-8	2021	CONCLUSIONS: The correlations between vitamin D and hepcidin levels, as well as between hepcidin and serum iron levels, are weak.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	88-96
34002827-9	2021	Interindividual variability in iron-hepcidin-vitamin D regulation might be wide and other regulatory mechanisms might also play important roles in inflammatory anemia modulation in the perioperative period.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	36-44
31258019-4	2021	Results: Iron-supplemented infants had higher Hb (103.7 +- 9.3 g L-1 versus 97.0 +- 9.4 g L-1, p &lt; .0001) and serum ferritin (133.93 +- 52.41 ng mL-1 versus 78.09 +- 42.03 ng mL-1, p &lt; .001) concentrations, compared with the no iron-supplementation group.	Iron	9-13	L1 cell adhesion molecule	Mus musculus	65-68
31258019-4	2021	Results: Iron-supplemented infants had higher Hb (103.7 +- 9.3 g L-1 versus 97.0 +- 9.4 g L-1, p &lt; .0001) and serum ferritin (133.93 +- 52.41 ng mL-1 versus 78.09 +- 42.03 ng mL-1, p &lt; .001) concentrations, compared with the no iron-supplementation group.	Iron	9-13	L1 cell adhesion molecule	Mus musculus	90-93
31258019-4	2021	Results: Iron-supplemented infants had higher Hb (103.7 +- 9.3 g L-1 versus 97.0 +- 9.4 g L-1, p &lt; .0001) and serum ferritin (133.93 +- 52.41 ng mL-1 versus 78.09 +- 42.03 ng mL-1, p &lt; .001) concentrations, compared with the no iron-supplementation group.	Iron	9-13	L1 cell adhesion molecule	Mus musculus	148-152
31258019-4	2021	Results: Iron-supplemented infants had higher Hb (103.7 +- 9.3 g L-1 versus 97.0 +- 9.4 g L-1, p &lt; .0001) and serum ferritin (133.93 +- 52.41 ng mL-1 versus 78.09 +- 42.03 ng mL-1, p &lt; .001) concentrations, compared with the no iron-supplementation group.	Iron	9-13	L1 cell adhesion molecule	Mus musculus	178-182
33947244-1	2021	Iron-sulfur (Fe-S) flavoproteins form a broad and growing class of complex, multi-domain and often multi-subunit proteins coupling the most ancient cofactors (the Fe-S clusters) and the most versatile coenzymes (the flavin coenzymes, FMN and FAD).	Iron	13-15	formin 1	Homo sapiens	234-237
33925597-4	2021	Dietary iron is taken up by the divalent metal transporter 1 (DMT1) in enterocytes and transported to portal blood via ferroportin (FPN), where it is bound to transferrin and taken up by hepatocytes, macrophages and bone marrow cells via transferrin receptor 1 (TfR1).	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	32-60
33925597-4	2021	Dietary iron is taken up by the divalent metal transporter 1 (DMT1) in enterocytes and transported to portal blood via ferroportin (FPN), where it is bound to transferrin and taken up by hepatocytes, macrophages and bone marrow cells via transferrin receptor 1 (TfR1).	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	62-66
33925597-6	2021	In response to an increased iron load, hepatocytes secrete the peptide hormone hepcidin, which binds to and induces internalization and degradation of the iron transporter FPN, thus controlling the amount of iron released from the cells into the blood.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	79-87
33925597-6	2021	In response to an increased iron load, hepatocytes secrete the peptide hormone hepcidin, which binds to and induces internalization and degradation of the iron transporter FPN, thus controlling the amount of iron released from the cells into the blood.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	79-87
33925597-6	2021	In response to an increased iron load, hepatocytes secrete the peptide hormone hepcidin, which binds to and induces internalization and degradation of the iron transporter FPN, thus controlling the amount of iron released from the cells into the blood.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	79-87
33923007-4	2021	The results of Principal Component Analysis (PCA) shows that four principal components (PCs) are responsible for describing the total metals concentrations" variance, the highest contribution on PC1 being that of Mn, and Cr, on PC2 that of Fe, on PC3 that of Cu, and on PC4 that of Al.	Iron	240-242	proprotein convertase subtilisin/kexin type 1	Homo sapiens	195-198
33923007-4	2021	The results of Principal Component Analysis (PCA) shows that four principal components (PCs) are responsible for describing the total metals concentrations" variance, the highest contribution on PC1 being that of Mn, and Cr, on PC2 that of Fe, on PC3 that of Cu, and on PC4 that of Al.	Iron	240-242	chromobox 4	Homo sapiens	228-231
33901632-4	2021	Most of iron exists in a protein-bound form, in erythrocytes as the heme compound hemoglobin, and in storage proteins such as ferritin, hemosiderin and myoglobin.	Iron	8-12	myoglobin	Homo sapiens	152-161
33891874-1	2021	The liver plays a pivotal role in the regulation of iron metabolism through its ability to sense and respond to iron stores by release of the hormone, hepcidin.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	151-159
33891874-1	2021	The liver plays a pivotal role in the regulation of iron metabolism through its ability to sense and respond to iron stores by release of the hormone, hepcidin.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	151-159
33891874-2	2021	Under physiological conditions, regulation of hepcidin expression in response to iron status maintains iron homeostasis.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	46-54
33891874-2	2021	Under physiological conditions, regulation of hepcidin expression in response to iron status maintains iron homeostasis.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	46-54
33891874-4	2021	The resulting dysregulation of hepcidin is proposed to account for alterations in iron homeostasis that are sometimes observed in patients with liver disease.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	31-39
33888314-0	2021	Intravenous iron supplementation after liver surgery: Impact on anemia, iron, and hepcidin levels-a randomized controlled trial.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	82-90
33888314-11	2021	Intravenous iron supplementation overcame the hepcidin-mediated blockade of iron absorption and should be considered as the preferred route of administration in the postoperative period.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	46-54
33888314-11	2021	Intravenous iron supplementation overcame the hepcidin-mediated blockade of iron absorption and should be considered as the preferred route of administration in the postoperative period.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	46-54
33954177-14	2021	The iron homeostasis response seems to be physiologically indicated by a tendency to increase hepcidin levels.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	94-102
33872860-12	2021	Increased hepatic iron levels induce oxidative stress and lipid peroxidation and aggravate insulin resistance, as indicated by diminished IRS1 phosphorylation and AKT activation.	Iron	18-22	insulin receptor substrate 1	Mus musculus	138-142
33829939-1	2021	beta-Thalassemia major (beta-TM) is a severe genetic hemoglobin (Hb) disorder with cardiovascular complications such as atherosclerosis due to transfusion-dependent iron overload.	Iron	165-169	ATM serine/threonine kinase	Homo sapiens	0-31
33787609-4	2021	Type 4B HH is a rare autosomal dominant disease that results from mutations in the Solute Carrier Family 40 member 1 (SLC40A1) gene, which encodes the iron transport protein ferroportin.	Iron	151-155	solute carrier family 40 member 1	Homo sapiens	83-116
33787609-4	2021	Type 4B HH is a rare autosomal dominant disease that results from mutations in the Solute Carrier Family 40 member 1 (SLC40A1) gene, which encodes the iron transport protein ferroportin.	Iron	151-155	solute carrier family 40 member 1	Homo sapiens	118-125
33483374-0	2021	MYCN-amplified neuroblastoma is addicted to iron and vulnerable to inhibition of the system Xc-/glutathione axis.	Iron	44-48	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
33483374-4	2021	Namely, amplified MYCN rewired the cell through expression of key receptors, ultimately enhancing iron influx through increased expression of the iron import transferrin receptor 1 (TfR1).	Iron	98-102	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	18-22
33483374-4	2021	Namely, amplified MYCN rewired the cell through expression of key receptors, ultimately enhancing iron influx through increased expression of the iron import transferrin receptor 1 (TfR1).	Iron	146-150	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	18-22
33483374-9	2021	DFO reduced auranofin-induced ROS, further linking increased iron capture in MYCN-amplified NB to a therapeutic vulnerability to ROS-inducing drugs.	Iron	61-65	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	77-81
33097833-4	2021	Mechanistically, ferroptosis inducers (erastin, sorafenib, and sulfasalazine) activated AMPK/SREBP1 signaling pathway through iron-dependent ferritinophagy, which in turn inhibited BCAT2 transcription.	Iron	126-130	sterol regulatory element binding transcription factor 1	Homo sapiens	93-99
33121804-7	2021	However, iron ions (Fe3+) significantly influenced the adsorption of Cd by DTC-LPEI-PUF.	Iron	9-13	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	84-87
33868231-2	2021	Hepcidin is a fascinating regulator of iron metabolism; however, the prognostic value of hepcidin and its correlation with immune cell infiltration in lung cancer remain unclear.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
34007348-1	2021	Genetic hemochromatosis causes iron overload by excess absorption of dietary iron, due to a decreased expression of hepcidin.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	116-124
34007348-1	2021	Genetic hemochromatosis causes iron overload by excess absorption of dietary iron, due to a decreased expression of hepcidin.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	116-124
33649797-9	2021	Mechanistically, miR-335 enhanced ferroptosis through the degradation of FTH1 to increase iron release, lipid peroxidation and reactive oxygen species (ROS) accumulation, and to decrease mitochondrial membrane potential (MMP).	Iron	90-94	ferritin heavy chain 1	Homo sapiens	73-77
33649802-0	2021	Iron overload in aging Bmp6-/- mice induces exocrine pancreatic injury and fibrosis due to acinar cell loss.	Iron	0-4	bone morphogenetic protein 6	Mus musculus	23-27
33649802-5	2021	The results demonstrated that 3-month-old Bmp6-/- mice exhibited iron accumulation preferentially in the exocrine pancreas, with no signs of pancreatic injury or fibrosis.	Iron	65-69	bone morphogenetic protein 6	Mus musculus	42-46
33649802-7	2021	Aging Bmp6-/- mice presented with progressive iron deposits in the exocrine pancreas, leading to pancreatic degeneration and injury that was characterized by acinar atrophy, fibrosis and the infiltration of inflammatory cells.	Iron	46-50	bone morphogenetic protein 6	Mus musculus	6-10
33649802-10	2021	These results supported a pathogenic role of iron overload in aging Bmp6-/- mice leading to iron-induced exocrine pancreatic deficiency, whereas the endocrine pancreas retained normal function.	Iron	45-49	bone morphogenetic protein 6	Mus musculus	68-72
33649802-10	2021	These results supported a pathogenic role of iron overload in aging Bmp6-/- mice leading to iron-induced exocrine pancreatic deficiency, whereas the endocrine pancreas retained normal function.	Iron	92-96	bone morphogenetic protein 6	Mus musculus	68-72
33443215-0	2021	Spinal NR2B phosphorylation at Tyr1472 regulates IRE(-)DMT1-mediated iron accumulation and spine morphogenesis via kalirin-7 in tibial fracture-associated postoperative pain after orthopedic surgery in female mice.	Iron	69-73	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	7-11
33443215-3	2021	Divalent metal transporter 1 (DMT1)-mediated iron overload involves NMDA-induced neurotoxicity in males.	Iron	45-49	solute carrier family 11 member 2	Homo sapiens	30-34
33443215-5	2021	Herein, the requirement for kalirin-7 in NR2B phosphorylation-dependent iron accumulation and spine plasticity in postoperative pain after tibial fracture in female mice has been examined.	Iron	72-76	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	41-45
33443215-12	2021	Spinal NMDA application elicits NR2B-dependent mechanical allodynia and iron overload, which is reversed by kalirin-7 knockdown or coadministration of deferoxamine.	Iron	72-76	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	32-36
33443215-13	2021	CONCLUSION: Spinal NR2B phosphorylation at Tyr1472 upregulates kalirin-7 expression to facilitate IRE (-) DMT1-mediated iron accumulation and spine morphogenesis in the development of fracture-associated postoperative pain in female mice.	Iron	120-124	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	19-23
33714956-3	2021	FPN1 is the only known mammalian iron exporter.	Iron	33-37	solute carrier family 40 member 1	Homo sapiens	0-4
33714956-10	2021	GO and KEGG analyses and GSEA suggested that FPN1 was remarkably related to iron homeostasis and immunity.	Iron	76-80	solute carrier family 40 member 1	Homo sapiens	45-49
33683742-6	2021	Divalent metal transporter 1(DMT1) decreased significantly, ferroportin 1 and ferritin increased significantly in the liver of UL iron group (p < 0.05).	Iron	130-134	solute carrier family 11 member 2	Homo sapiens	29-33
33683742-6	2021	Divalent metal transporter 1(DMT1) decreased significantly, ferroportin 1 and ferritin increased significantly in the liver of UL iron group (p < 0.05).	Iron	130-134	solute carrier family 40 member 1	Homo sapiens	60-73
33673803-0	2021	Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: a case report.	Iron	53-57	solute carrier family 40 member 1	Homo sapiens	123-130
33673803-2	2021	Hepcidin is a soluble regulator that acts to attenuate both intestinal iron absorption and iron release from reticuloendothelial macrophages through internalization of ferroportin-1, an iron exporter.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	0-8
33673803-2	2021	Hepcidin is a soluble regulator that acts to attenuate both intestinal iron absorption and iron release from reticuloendothelial macrophages through internalization of ferroportin-1, an iron exporter.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
33673803-2	2021	Hepcidin is a soluble regulator that acts to attenuate both intestinal iron absorption and iron release from reticuloendothelial macrophages through internalization of ferroportin-1, an iron exporter.	Iron	91-95	solute carrier family 40 member 1	Homo sapiens	168-181
33673803-2	2021	Hepcidin is a soluble regulator that acts to attenuate both intestinal iron absorption and iron release from reticuloendothelial macrophages through internalization of ferroportin-1, an iron exporter.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
33673803-2	2021	Hepcidin is a soluble regulator that acts to attenuate both intestinal iron absorption and iron release from reticuloendothelial macrophages through internalization of ferroportin-1, an iron exporter.	Iron	91-95	solute carrier family 40 member 1	Homo sapiens	168-181
33673803-12	2021	CONCLUSIONS: The present case demonstrated for the first time that there was a correlation between hepatic iron levels as measured by MRI and serum hepcidin levels through long-term phlebotomy in a patient with ferroportin disease with the p.H507R mutation of in SLC40A1.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	148-156
33673803-12	2021	CONCLUSIONS: The present case demonstrated for the first time that there was a correlation between hepatic iron levels as measured by MRI and serum hepcidin levels through long-term phlebotomy in a patient with ferroportin disease with the p.H507R mutation of in SLC40A1.	Iron	107-111	solute carrier family 40 member 1	Homo sapiens	263-270
33340587-2	2021	Fpn plasma membrane expression is controlled by the hepatic iron-regulated hormone hepcidin in response to high iron availability and inflammation.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	83-91
33340587-2	2021	Fpn plasma membrane expression is controlled by the hepatic iron-regulated hormone hepcidin in response to high iron availability and inflammation.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	83-91
33340587-3	2021	Hepcidin binds to the central cavity of the Fpn transporter to block iron export either directly or by inducing Fpn internalization and lysosomal degradation.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
33340587-6	2021	RESULTS: We show that iron deficiency does not affect basal Fpn turnover but causes a significant delay in hepcidin-induced degradation when cytosolic iron levels are low.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	107-115
33340587-7	2021	CONCLUSIONS/GENERAL SIGNIFICANCE: These data have important mechanistic implications supporting the hypothesis that iron export is required for efficient targeting of Fpn by hepcidin.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	174-182
32468223-4	2021	Iron overload upregulated the pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, TNF-alpha), while downregulated the anti-inflammatory cytokines (IL-4, IL-10) and sIgA.	Iron	0-4	interleukin 1 alpha	Mus musculus	58-66
32468223-4	2021	Iron overload upregulated the pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, TNF-alpha), while downregulated the anti-inflammatory cytokines (IL-4, IL-10) and sIgA.	Iron	0-4	interleukin 2	Mus musculus	68-72
32468223-4	2021	Iron overload upregulated the pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, TNF-alpha), while downregulated the anti-inflammatory cytokines (IL-4, IL-10) and sIgA.	Iron	0-4	interleukin 4	Mus musculus	145-149
33315792-6	2021	Hepcidin holds future promise as a marker of iron status during inflammatory states.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
33507238-4	2021	The signal of iron deprivation requires Tor2/Ypk1 activity and the inactivation of Tor1 leading to Atg13 dephosphorylation, thus triggering the autophagy process.	Iron	14-18	phosphatidylinositol kinase-related protein kinase TOR2	Saccharomyces cerevisiae S288C	40-44
33507238-4	2021	The signal of iron deprivation requires Tor2/Ypk1 activity and the inactivation of Tor1 leading to Atg13 dephosphorylation, thus triggering the autophagy process.	Iron	14-18	serine/threonine protein kinase regulatory subunit ATG13	Saccharomyces cerevisiae S288C	99-104
33643023-3	2021	However, iron and carbon monoxide produced by the catabolism of HO-1 exert detrimental effects on patients with PD.	Iron	9-13	heme oxygenase 1	Homo sapiens	64-68
33603367-6	2021	MIL-101(Fe)@sor NPs significantly induced ferroptosis in HepG2 cells, increased the levels of lipid peroxidation and malondialdehyde, and reduced those of glutathione and glutathione peroxidase 4 (GPX-4).	Iron	8-10	glutathione peroxidase 4	Homo sapiens	171-195
33603367-6	2021	MIL-101(Fe)@sor NPs significantly induced ferroptosis in HepG2 cells, increased the levels of lipid peroxidation and malondialdehyde, and reduced those of glutathione and glutathione peroxidase 4 (GPX-4).	Iron	8-10	glutathione peroxidase 4	Homo sapiens	197-202
33603367-7	2021	The in vivo results showed that the MIL-101(Fe)@sor NPs significantly inhibited tumor progression and decreased GPX-4 expression levels, with negligible long-term toxicity.	Iron	44-46	glutathione peroxidase 4	Homo sapiens	112-117
33562493-1	2021	Lipoyl synthase (LIAS) is an iron-sulfur cluster protein and a member of the radical S-adenosylmethionine (SAM) superfamily that catalyzes the final step of lipoic acid biosynthesis.	Iron	29-33	lipoic acid synthetase	Homo sapiens	0-15
33562493-1	2021	Lipoyl synthase (LIAS) is an iron-sulfur cluster protein and a member of the radical S-adenosylmethionine (SAM) superfamily that catalyzes the final step of lipoic acid biosynthesis.	Iron	29-33	lipoic acid synthetase	Homo sapiens	17-21
33562493-4	2021	Herein, we detail the expression, isolation, and characterization of human LIAS, its reactivity, and evaluation of natural iron-sulfur (Fe-S) cluster reconstitution mechanisms.	Iron	136-140	lipoic acid synthetase	Homo sapiens	75-79
33562493-9	2021	Likely in vivo Fe-S cluster donors to LIAS are identified, with possible connections to human disease states, and a mechanistic ordering of [4Fe-4S] cluster reconstitution is evident.	Iron	15-17	lipoic acid synthetase	Homo sapiens	38-42
33746574-1	2021	Melanotransferrin (CD228), firstly reported as a melanoma-associated antigen, is a membrane-bound glycoprotein of an iron-binding transferrin homolog.	Iron	117-121	melanotransferrin	Homo sapiens	0-17
33746574-1	2021	Melanotransferrin (CD228), firstly reported as a melanoma-associated antigen, is a membrane-bound glycoprotein of an iron-binding transferrin homolog.	Iron	117-121	melanotransferrin	Homo sapiens	19-24
33746574-1	2021	Melanotransferrin (CD228), firstly reported as a melanoma-associated antigen, is a membrane-bound glycoprotein of an iron-binding transferrin homolog.	Iron	117-121	ankyrin repeat domain 36B	Homo sapiens	49-76
33184627-1	2021	BACKGROUND: Strenuous physical activity promotes inflammation and depletes muscle glycogen, which may increase the iron regulatory hormone hepcidin.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	139-147
33184627-2	2021	Hepcidin reduces dietary iron absorption and may contribute to declines in iron status frequently observed following strenuous physical activity.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	0-8
33184627-2	2021	Hepcidin reduces dietary iron absorption and may contribute to declines in iron status frequently observed following strenuous physical activity.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
33462110-2	2021	Rab11fip5 is involved in many cellular processes, such as cytoskeleton rearrangement, iron uptake, and exocytosis in neuroendocrine cells and also known as a candidate gene for autism-spectrum disorder.	Iron	86-90	RAB11 family interacting protein 5	Homo sapiens	0-9
33527915-1	2021	In this work we report experimental evidence for the weak high-temperature ferromagnetism in Bi1-x R x FeO3 (R = Dy, Y) compounds by systematic characterizations, excluding the possible side-effects from other iron-based impurities.	Iron	210-214	transmembrane BAX inhibitor motif containing 6	Homo sapiens	93-96
33517264-11	2021	To our knowledge, this is the first biological function ascribed to human hepcidin that is not related to its antimicrobial and iron-regulatory properties.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	74-82
33226839-0	2021	Artificial Maturation of Iron- and Sulfur-Rich Mars Analogues: Implications for the Diagenetic Stability of Biopolymers and Their Detection with Pyrolysis-Gas Chromatography-Mass Spectrometry.	Iron	25-29	methionyl-tRNA synthetase 1	Homo sapiens	47-51
33297749-1	2021	OBJECTIVE: NFU1 is a mitochondrial iron-sulfur scaffold protein, involved in iron-sulfur assembly and transfer to complex II and LAS (lipoic acid synthase).	Iron	35-39	NFU1 iron-sulfur cluster scaffold	Rattus norvegicus	11-15
33297749-1	2021	OBJECTIVE: NFU1 is a mitochondrial iron-sulfur scaffold protein, involved in iron-sulfur assembly and transfer to complex II and LAS (lipoic acid synthase).	Iron	35-39	lipoic acid synthetase	Rattus norvegicus	134-154
33297749-1	2021	OBJECTIVE: NFU1 is a mitochondrial iron-sulfur scaffold protein, involved in iron-sulfur assembly and transfer to complex II and LAS (lipoic acid synthase).	Iron	77-81	NFU1 iron-sulfur cluster scaffold	Rattus norvegicus	11-15
33297749-1	2021	OBJECTIVE: NFU1 is a mitochondrial iron-sulfur scaffold protein, involved in iron-sulfur assembly and transfer to complex II and LAS (lipoic acid synthase).	Iron	77-81	lipoic acid synthetase	Rattus norvegicus	134-154
33297854-6	2021	Further, the transcription factors (TFs) analysis and gene co-expression network analysis indicated three hub differentially expressed TFs (NR2F2, TFAP2D, and HNF1B) that affected FE by mainly regulating feeding behavior, insulin sensitivity, or energy metabolism.	Iron	180-182	nuclear receptor subfamily 2 group F member 2	Sus scrofa	140-145
33297854-6	2021	Further, the transcription factors (TFs) analysis and gene co-expression network analysis indicated three hub differentially expressed TFs (NR2F2, TFAP2D, and HNF1B) that affected FE by mainly regulating feeding behavior, insulin sensitivity, or energy metabolism.	Iron	180-182	hepatocyte nuclear factor 1-beta	Sus scrofa	159-164
33382424-2	2021	However, no specific hormonal "feedback" regulation for Se status has yet been identified in contrast to the fine-tuned hormone network regulating the Ca 2+ and phosphate balance or the hepcidin-related iron status.Since its discovery as an essential trace element, effects of Se excess or deficiency on the endocrine system or components of the hypothalamic-pituitary-periphery feedback circuits, the thyroid hormone axis, glucoregulatory and adrenal hormones, male and female gonads, the musculo-skeletal apparatus and skin have been identified.	Iron	203-207	hepcidin antimicrobial peptide	Homo sapiens	186-194
33512059-1	2021	A new family of transition-metal monosilicides (MSi, M = Ti, Mn, Fe, Ru, Ni, Pd, Co, and Rh) electrocatalysts with superior electrocatalytic performance of hydrogen evolution is reported, based on the computational and experimental results.	Iron	65-67	RB binding protein 4, chromatin remodeling factor	Homo sapiens	48-51
33554822-1	2021	OBJECTIVE: To detect serum hepcidin and erythroferrone levels in child-bearing women with iron deficiency anemia (IDA), and to investigate the association between them and iron status parameters.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	27-35
33554822-9	2021	In IDA patients, serum hepcidin concentrations were positively correlated with hemoglobin concentration, serum iron, serum ferritin and transferrin saturation (r=0.448, r=0.496, r=0.754, r=0.491).	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	23-31
33513924-4	2021	Hepcidin, the key regulator of iron homeostasis, decreases to facilitate iron efflux into the circulation during enhanced erythropoiesis.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
33513924-4	2021	Hepcidin, the key regulator of iron homeostasis, decreases to facilitate iron efflux into the circulation during enhanced erythropoiesis.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
33498856-1	2021	In this work, we present a strategy to improve the gas-sensing performance of NiFe2O4 via a controllable annealing Ni/Fe precursor to fluffy NiFe2O4 nanosheet flowers.	Iron	80-82	gastrin	Homo sapiens	51-54
33210665-0	2021	Acid-etched Fe/Fe2O3 nanoparticles encapsulated into carbon cloth as a novel voltammetric sensor for the simultaneous detection of Cd2+ and Pb2.	Iron	12-14	CD2 molecule	Homo sapiens	131-134
33210665-2	2021	In this paper, a novel flexible, disposable sensor for Cd2+ and Pb2+ with ultrahigh sensitivity and a fast response, based on acid-etched Fe/Fe2O3 encapsulated into a disposable carbon cloth electrode, has been successfully fabricated.	Iron	138-140	CD2 molecule	Homo sapiens	55-58
33462917-10	2021	Parenteral iron caused elevations in hepcidin sustained to four weeks post injection.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	37-45
33157103-2	2021	Iron-sulfur cofactors are assembled primarily in mitochondria and are then exported to the cytosol by use of an ABCB7 transporter.	Iron	0-4	ATP binding cassette subfamily B member 7	Homo sapiens	112-117
32818713-5	2021	The hydrogel allows two iron substrates to adhere together at -40  C with the lap-shear adhesion strength as high as ~1 MPa.	Iron	24-28	LAP	Homo sapiens	78-81
32916576-0	2021	Fe-modified Co2(OH)3Cl microspheres for highly efficient oxygen evolution reaction.	Iron	0-2	complement C2	Homo sapiens	12-15
32916576-3	2021	Furthermore, the OER activity of Co2(OH)3Cl can be further enhanced after small amounts of Fe modification (Fe2+ as precursor).	Iron	91-93	complement C2	Homo sapiens	33-36
32916576-4	2021	Fe doping into Co2(OH)3Cl lattices can make the etching of surface lattice Cl- easier and generate more surface vacancies to absorb oxygen species.	Iron	0-2	complement C2	Homo sapiens	15-18
33207532-1	2021	Bifunctional Bi12O17Cl2/MIL-100(Fe) composite (BMx) was firstly constructed via facile ball-milling method.	Iron	32-34	BMX non-receptor tyrosine kinase	Homo sapiens	47-50
33440611-1	2021	Heme Oxygenase-1 (HO-1) is a type II detoxifying enzyme that catalyzes the rate-limiting step in heme degradation leading to the formation of equimolar quantities of carbon monoxide (CO), free iron and biliverdin.	Iron	193-197	heme oxygenase 1	Homo sapiens	0-16
33440611-1	2021	Heme Oxygenase-1 (HO-1) is a type II detoxifying enzyme that catalyzes the rate-limiting step in heme degradation leading to the formation of equimolar quantities of carbon monoxide (CO), free iron and biliverdin.	Iron	193-197	heme oxygenase 1	Homo sapiens	18-22
33430754-4	2021	Bovine lactoferrin (bLf) is an iron-binding multifunctional glycoprotein that exhibits modulatory properties on neuroendocrine system.	Iron	31-35	lactotransferrin	Bos taurus	7-18
33345646-6	2021	There has been exciting progress in understanding iron metabolism and regulation since hepcidin was recognized as the central regulator of iron homeostasis.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	87-95
33345646-6	2021	There has been exciting progress in understanding iron metabolism and regulation since hepcidin was recognized as the central regulator of iron homeostasis.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	87-95
33345646-7	2021	Hepcidin mainly regulates the iron export function of the ferrous iron permease, ferroportin, which is the only known iron exporter expressed by mammalian cells.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
33345646-7	2021	Hepcidin mainly regulates the iron export function of the ferrous iron permease, ferroportin, which is the only known iron exporter expressed by mammalian cells.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
33345646-7	2021	Hepcidin mainly regulates the iron export function of the ferrous iron permease, ferroportin, which is the only known iron exporter expressed by mammalian cells.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
33345646-9	2021	Epigenetic phenomena have been demonstrated to modulate key proteins including hepcidin in iron metabolism.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	79-87
33419006-5	2021	Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1).	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	47-55
33419006-5	2021	Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1).	Iron	106-110	solute carrier family 40 member 1	Homo sapiens	187-200
33419006-5	2021	Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1).	Iron	106-110	solute carrier family 40 member 1	Homo sapiens	202-206
33245133-10	2021	Pigs in the H-Fe group had greater dendritic complexity in CA1/3 pyramidal neurons than L-Fe group pigs as shown by more dendritic intersections with Sholl rings (P <= 0.04) and a greater number of dendrites (P <= 0.016).	Iron	14-16	carbonic anhydrase 13	Sus scrofa	59-64
32215811-0	2021	Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1alpha/MAPK Pathway in the Liver.	Iron	18-22	growth hormone secretagogue receptor	Mus musculus	89-99
32215811-8	2021	Our findings confirmed that fasting increases iron export in the liver by upregulating Fpn1 expression through the ghrelin/GHSR1alpha/MAPK signaling pathway.	Iron	46-50	growth hormone secretagogue receptor	Mus musculus	123-133
33247551-2	2021	Circulating hepcidin controls iron efflux by inducing degradation of the cellular iron exporter ferroportin.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	12-20
33247551-2	2021	Circulating hepcidin controls iron efflux by inducing degradation of the cellular iron exporter ferroportin.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	12-20
33475464-0	2021	Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin-ferroportin axis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	97-105
33475464-4	2021	Here, we demonstrated that SpvB facilitated Salmonella to scavenge iron from the host by modulating the hepcidin-ferroportin axis, a key regulator of systemic iron metabolism.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	104-112
33475464-4	2021	Here, we demonstrated that SpvB facilitated Salmonella to scavenge iron from the host by modulating the hepcidin-ferroportin axis, a key regulator of systemic iron metabolism.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	104-112
33475464-8	2021	Our data supported a role of TREM-1 in SpvB-related dysregulation of host iron metabolism and suggested that targeting TREM-1 might provide a potential therapeutic strategy to prevent or alleviate Salmonella pathogenesis.	Iron	74-78	triggering receptor expressed on myeloid cells 1	Homo sapiens	29-35
33475464-8	2021	Our data supported a role of TREM-1 in SpvB-related dysregulation of host iron metabolism and suggested that targeting TREM-1 might provide a potential therapeutic strategy to prevent or alleviate Salmonella pathogenesis.	Iron	74-78	triggering receptor expressed on myeloid cells 1	Homo sapiens	119-125
33390840-7	2021	Moreover, our results showed that iron overload upregulated the expression of P53, which subsequently repressed the protein level of Slc7a11 (solute carrier family 7, member 11), a known ferroptosis-related gene.	Iron	34-38	transformation related protein 53, pseudogene	Mus musculus	78-81
33390840-9	2021	The findings in this study indicate that iron plays a key role in triggering P53- Slc7a11-mediated ferroptosis in muscles, and suggest that targeting iron accumulation and ferroptosis might be a therapeutic strategy for treating sarcopenia.	Iron	41-45	transformation related protein 53, pseudogene	Mus musculus	77-80
33189279-14	2021	The genes FN1 (fibronectin 1) and PTK2 (protein tyrosine kinase 2), which are mainly involved in cell adhesion and formation of extracellular matrix constituents, were enriched for QTL previously associated with the trait "ketosis" on chromosome 2 and for the trait "milk iron content" on chromosome 14, respectively.	Iron	272-276	fibronectin 1	Bos taurus	10-13
33189279-14	2021	The genes FN1 (fibronectin 1) and PTK2 (protein tyrosine kinase 2), which are mainly involved in cell adhesion and formation of extracellular matrix constituents, were enriched for QTL previously associated with the trait "ketosis" on chromosome 2 and for the trait "milk iron content" on chromosome 14, respectively.	Iron	272-276	fibronectin 1	Bos taurus	15-28
33189279-14	2021	The genes FN1 (fibronectin 1) and PTK2 (protein tyrosine kinase 2), which are mainly involved in cell adhesion and formation of extracellular matrix constituents, were enriched for QTL previously associated with the trait "ketosis" on chromosome 2 and for the trait "milk iron content" on chromosome 14, respectively.	Iron	272-276	protein tyrosine kinase 2	Bos taurus	34-38
33189279-14	2021	The genes FN1 (fibronectin 1) and PTK2 (protein tyrosine kinase 2), which are mainly involved in cell adhesion and formation of extracellular matrix constituents, were enriched for QTL previously associated with the trait "ketosis" on chromosome 2 and for the trait "milk iron content" on chromosome 14, respectively.	Iron	272-276	protein tyrosine kinase 2	Bos taurus	40-65
33510107-10	2021	There was a strong correlation between ferritin and hepcidin (rho=0.720, p<0.001), and a relatively lower increment of hepcidin for the degree of iron overload in beta- NTDT compared to beta-TT.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	119-127
33683041-1	2021	BACKGROUND AND OBJECTIVE: Hepcidin, a key element in iron hemostasis, is a small antimicrobial peptide encoded by the HAMP gene on 19q13.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	26-34
32974958-2	2021	Therefore, we aimed here to reveal in vivo developmental expression, subcellular, tissue- and organ-specific localisation of iron superoxide dismutase FSD1 in Arabidopsis using light-sheet and Airyscan confocal microscopy.	Iron	125-129	Fe superoxide dismutase 1	Arabidopsis thaliana	151-155
33040451-9	2021	We also found that the N-terminal iron-sulphur cluster domain of AtABCE2 is crucial for its suppressor function.	Iron	34-38	RNAse l inhibitor protein 2	Arabidopsis thaliana	65-72
33075721-0	2021	Role of heme oxygenase-1 in human placenta on iron supply to fetus.	Iron	46-50	heme oxygenase 1	Homo sapiens	8-24
33075721-2	2021	Recently, increasing evidence has shown that heme oxygenase (HO)-1, which is an inducible isoform of the rate-limiting enzyme in the heme degradation pathway, may be involved in the effective reutilization of iron.	Iron	209-213	heme oxygenase 1	Homo sapiens	45-66
33075721-9	2021	Placenta with fetal death (miscarriage) in the first and second trimester indicate significantly higher ratio of ho-1 gene for iron production to the fpn-1 gene for iron excretion than normal.	Iron	127-131	heme oxygenase 1	Homo sapiens	113-117
33075721-9	2021	Placenta with fetal death (miscarriage) in the first and second trimester indicate significantly higher ratio of ho-1 gene for iron production to the fpn-1 gene for iron excretion than normal.	Iron	165-169	solute carrier family 40 member 1	Homo sapiens	150-155
33075721-11	2021	DISCUSSION: These findings suggest that HO-1 in placenta plays an important role in iron supplying system in the second trimester to support fetal development.	Iron	84-88	heme oxygenase 1	Homo sapiens	40-44
33417382-1	2020	PURPOSE: Woodhouse-Sakati syndrome is a rare autosomal recessive syndrome caused by homozygous mutations in the DCAF17 gene, characterized by marked neurologic and endocrine manifestations in the setting of brain iron accumulation and white matter lesions on neuroimaging.	Iron	213-217	DDB1 and CUL4 associated factor 17	Homo sapiens	112-118
33520544-6	2020	Correlation analysis was done between serum hepcidin and serum iron, serum hepcidin, and insulin resistance, and serum iron and insulin resistance by applying the Spearman correlation test.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	44-52
33392110-5	2020	SpvB is a key effector encoded within this locus, and closely related to Salmonella pathogenicity such as interfering with autophagy and iron homeostasis.	Iron	137-141	Salmonella plasmid virulence protein B	Salmonella enterica subsp. enterica serovar Typhimurium	0-4
33415156-6	2020	The SF and TS levels indicate iron status, while hepcidin level indicates iron regulator status.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	49-57
33415156-16	2020	Hepcidin serum level tends to increase when iron overload just started.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
33321938-3	2020	Specifically, in the context of Friedreich"s ataxia (FRDA), thioredoxin family proteins may have a special role in the regulation of Nrf2 expression and function, in Fe-S cluster metabolism, controlling the expression of genes located at the iron-response element (IRE) and probably regulating ferroptosis.	Iron	166-170	thioredoxin	Homo sapiens	60-71
33321938-3	2020	Specifically, in the context of Friedreich"s ataxia (FRDA), thioredoxin family proteins may have a special role in the regulation of Nrf2 expression and function, in Fe-S cluster metabolism, controlling the expression of genes located at the iron-response element (IRE) and probably regulating ferroptosis.	Iron	242-246	thioredoxin	Homo sapiens	60-71
33283302-9	2021	Animals injected with EPO showed decreased Fe deposition, although there was no relation between EPO administration and osteoid formation in the femur.	Iron	43-45	erythropoietin	Rattus norvegicus	22-25
33291388-2	2020	Lactoferrin (LF) is an iron-binding protein present in saliva, tears, and mother"s milk.	Iron	23-27	lactotransferrin	Mus musculus	0-11
33275743-6	2020	In the growing number of survivors of Bart hydrops fetalis, the approach to transfusion therapy and iron chelation is rapidly evolving.	Iron	100-104	ADP ribosylation factor like GTPase 2 binding protein	Homo sapiens	38-42
33344403-6	2020	We used a carbon-beam (14 keV/mum) that was shown to induce a p53-dependent effect and an iron-beam (189 keV/mum) that was shown to induce a p53-independent effect in a previous study.	Iron	90-94	transformation related protein 53, pseudogene	Mus musculus	141-144
33242392-4	2020	We demonstrate that fSHAPE patterns predict binding sites of known RBPs, such as iron response elements in both known loci and previously unknown loci in CDC34, SLC2A4RG, COASY, and H19.	Iron	81-85	H19 imprinted maternally expressed transcript	Homo sapiens	182-185
33276470-1	2020	Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin.	Iron	121-125	heme oxygenase 1	Homo sapiens	0-16
33276470-1	2020	Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin.	Iron	121-125	heme oxygenase 1	Homo sapiens	18-22
34043488-0	2022	Heme-iron ligand (M80-Fe) in cytochrome c is destabilizing: combined in vitro and in silico approaches to monitor changes in structure, stability and dynamics of the protein on mutation.	Iron	5-9	cytochrome c, somatic	Equus caballus	29-41
34043488-4	2022	To understand this ligation better, Met80 of horse cyt c has been mutated to Gly that is unable to bind to the heme iron.	Iron	116-120	cytochrome c, somatic	Equus caballus	51-56
33104871-4	2020	The RET-He is a cost-effective parameter for the diagnosis and monitoring of the iron supply for erythropoiesis.	Iron	81-85	ret proto-oncogene	Homo sapiens	4-7
32960376-2	2020	The hormone hepcidin is a systemic regulator of iron concentration in plasma.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	12-20
32960376-10	2020	Plasma hepcidin was not associated with high-sensitivity C-reactive protein, but it was significantly associated (r >= 0.32) with iron indices, including total iron (p < 0.01), transferrin (p < 0.01) and soluble transferrin receptor (p < 0.01).	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	7-15
32960376-10	2020	Plasma hepcidin was not associated with high-sensitivity C-reactive protein, but it was significantly associated (r >= 0.32) with iron indices, including total iron (p < 0.01), transferrin (p < 0.01) and soluble transferrin receptor (p < 0.01).	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	7-15
32009585-6	2020	High levels of hepcidin could induce negative iron metabolism in hematopoiesis.Conclusion: Therefore, controlling hepcidin levels to within approximately 20-70 ng/mL may prevent iron deficiency and reduced Hb synthesis, and may thus facilitate effective iron utilization in hematopoiesis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	15-23
32009585-6	2020	High levels of hepcidin could induce negative iron metabolism in hematopoiesis.Conclusion: Therefore, controlling hepcidin levels to within approximately 20-70 ng/mL may prevent iron deficiency and reduced Hb synthesis, and may thus facilitate effective iron utilization in hematopoiesis.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	114-122
32009585-6	2020	High levels of hepcidin could induce negative iron metabolism in hematopoiesis.Conclusion: Therefore, controlling hepcidin levels to within approximately 20-70 ng/mL may prevent iron deficiency and reduced Hb synthesis, and may thus facilitate effective iron utilization in hematopoiesis.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	15-23
32009585-6	2020	High levels of hepcidin could induce negative iron metabolism in hematopoiesis.Conclusion: Therefore, controlling hepcidin levels to within approximately 20-70 ng/mL may prevent iron deficiency and reduced Hb synthesis, and may thus facilitate effective iron utilization in hematopoiesis.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	114-122
33231816-0	2020	Relation of hepcidin gene expression in blood mononuclear cells with iron overload severity among beta-thalassemia major patients.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	12-20
33231816-2	2020	Hepcidin, a liver-derived peptide hormone, plays a key role in plasma iron levels regulation by controlling two main stages, digestive iron absorption in enterocytes, and iron recycling in macrophages.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
33231816-2	2020	Hepcidin, a liver-derived peptide hormone, plays a key role in plasma iron levels regulation by controlling two main stages, digestive iron absorption in enterocytes, and iron recycling in macrophages.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	0-8
33231816-2	2020	Hepcidin, a liver-derived peptide hormone, plays a key role in plasma iron levels regulation by controlling two main stages, digestive iron absorption in enterocytes, and iron recycling in macrophages.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	0-8
33231816-7	2020	There was a significantly positive correlation between the cardiac iron concentration, showed by higher T2 values, and hepcidin levels in the patients (p = 0.028; r = 0.311).	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	119-127
33231816-9	2020	Hepcidin can act as a beneficial marker to determine iron overload degrees, particularly in the heart, in beta-thalassemia major patients and be used as a logical therapeutic agent for treatment of beta-thalassemia disorders.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	0-8
32920472-6	2020	These results suggest that estrogen deficiency with an increase of hepcidin is partly responsible for iron deposition in the brain and brain endothelial cells and that hepcidin can be a target to prevent brain aging and neurodegeneration in postmenopausal women.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	67-75
32746765-2	2020	Hepcidin is an endogenous peptide hormone that serves as a key regulator of iron metabolism, and ferroportin and ZIP8 are iron transporters.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
32976958-7	2020	Both HFD-fed mice and PA/OA-induced HepG2 cells displayed ferroptosis-based panel of biomarkers such as iron overload with the up-regulation of TFR1 and the down-regulation of FTH1, lipid peroxidation and inhibition of Nrf2 activity, which further induced GPX4 and HO-1 levels.	Iron	104-108	ferritin heavy chain 1	Homo sapiens	176-180
32976958-7	2020	Both HFD-fed mice and PA/OA-induced HepG2 cells displayed ferroptosis-based panel of biomarkers such as iron overload with the up-regulation of TFR1 and the down-regulation of FTH1, lipid peroxidation and inhibition of Nrf2 activity, which further induced GPX4 and HO-1 levels.	Iron	104-108	glutathione peroxidase 4	Homo sapiens	256-260
32976958-7	2020	Both HFD-fed mice and PA/OA-induced HepG2 cells displayed ferroptosis-based panel of biomarkers such as iron overload with the up-regulation of TFR1 and the down-regulation of FTH1, lipid peroxidation and inhibition of Nrf2 activity, which further induced GPX4 and HO-1 levels.	Iron	104-108	heme oxygenase 1	Homo sapiens	265-269
33124826-5	2020	These results show the oxidation/spin states of the Fe atom in myoglobin in the gas phase and were compared with the aqueous solution from the obtained resonant Raman spectra.	Iron	52-54	myoglobin	Homo sapiens	63-72
33124826-5	2020	These results show the oxidation/spin states of the Fe atom in myoglobin in the gas phase and were compared with the aqueous solution from the obtained resonant Raman spectra.	Iron	52-54	gastrin	Homo sapiens	80-83
32791852-4	2021	The amount and distribution of iron thus need to be tightly regulated by the liver-expressed hormone hepcidin.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	101-109
32743925-2	2020	Herein, we demonstrate MIL-100 (Fe) serves as an ideal SERS substrate for VOCs detection.	Iron	32-34	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	55-59
33192053-7	2020	Recent studies have shown the effects of SGLT2Is on cardiac iron homeostasis, mitochondrial function, anti-inflammation, anti-fibrosis, antioxidative stress, and renin-angiotensin-aldosterone system activity, as well as GlcNAcylation in the heart.	Iron	60-64	solute carrier family 5 member 2	Homo sapiens	41-46
33525240-5	2020	Therefore, both local and systemic hepcidin levels could serve as a dynamic marker of disease progression (the more hepcidin the worse is disease) and treatment efficacy (after iron homeostasis is recovered hepcidin disappears).	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	35-43
33204390-3	2020	Human transferrin (hTf) is a clinically significant protein that plays a pivotal role in maintaining iron homeostasis.	Iron	101-105	coagulation factor III, tissue factor	Homo sapiens	19-22
33204390-4	2020	The importance of studies pertaining to hTf is attributable to the pivotal role of iron deposition in CNS in neurodegenerative disorders.	Iron	83-87	coagulation factor III, tissue factor	Homo sapiens	40-43
32827718-2	2020	Glutathione peroxidase 4 (GPX4) acts as a hydroperoxidase which prevents accumulation of toxic oxidized lipids and blocks ferroptosis, an iron-dependent, non-apoptotic mode of cell death.	Iron	138-142	glutathione peroxidase 4	Homo sapiens	0-24
32827718-2	2020	Glutathione peroxidase 4 (GPX4) acts as a hydroperoxidase which prevents accumulation of toxic oxidized lipids and blocks ferroptosis, an iron-dependent, non-apoptotic mode of cell death.	Iron	138-142	glutathione peroxidase 4	Homo sapiens	26-30
32705943-2	2020	Systemic iron homeostasis is regulated by the interaction of the peptide hormone, hepcidin and the iron exporter, ferroportin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	82-90
32682623-2	2020	It is an autosomal recessive disorder due to mutations in ceruloplasmin gene causing systemic iron overload, including cerebral and liver parenchyma.	Iron	94-98	ceruloplasmin	Homo sapiens	58-71
32682623-3	2020	The impairment of ferroxidase ceruloplasmin activity leads to intracellular iron retention leading aceruloplasminemia symptoms.	Iron	76-80	ceruloplasmin	Homo sapiens	30-43
32682623-7	2020	Ceruloplasmin dosage is required in case of low transferrin saturation and high hepatic iron content and genetic testing is mandatory in case of serum ceruloplasmin defect.	Iron	88-92	ceruloplasmin	Homo sapiens	0-13
32492604-4	2020	Subsequently, lysosomal dysfunction mediated by iron increased mitochondrial membrane permeability and decreased mitochondrial membrane potential, thereby enhancing Bid and cytochrome c release and caspase-9/-3 activation (P < 0.05).	Iron	48-52	BH3 interacting domain death agonist	Bos taurus	165-168
33145027-11	2020	We confirmed further that iron activates canonical Wnt signaling in the retina using TOPFlash T-cell factor/lymphoid enhancer factor promoter assay and Axin2-LacZ reporter mouse.	Iron	26-30	axin 2	Mus musculus	152-157
33095336-0	2020	Gold-silver core-shell nanoparticle-based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidin.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	112-120
33095336-8	2020	Graphical abstract Gold-silver core-shell nanoparticle-based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidin.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	131-139
33095336-9	2020	The study focuses on the detection of iron regulatory protein hepcidin using gold-silver core-shell nanoparticles.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	62-70
33116818-2	2020	Thus, hepcidin (Hp) and ferroportin (Fpn) are molecules that regulate and maintain the metabolism of iron.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	6-14
33116818-3	2020	A peptide hormone hepcidin limits recycled and stored iron fluxes in macrophage and hepatic hepatocyte, respectively, to the blood stream by promoting degradation of the only iron exporter, Fpn, in the target cells.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	18-26
33116818-3	2020	A peptide hormone hepcidin limits recycled and stored iron fluxes in macrophage and hepatic hepatocyte, respectively, to the blood stream by promoting degradation of the only iron exporter, Fpn, in the target cells.	Iron	175-179	hepcidin antimicrobial peptide	Homo sapiens	18-26
33116818-10	2020	Here, we review the key molecular aspects of iron metabolism and its regulatory mechanisms of the hepcidin/ferroportin pathways and its current therapeutic strategies in breast cancer.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	98-106
33066821-5	2020	Hepcidin is thought to be the key regulator of iron metabolism in humans through its inhibition of the iron-exporting protein ferroportin.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
33066821-5	2020	Hepcidin is thought to be the key regulator of iron metabolism in humans through its inhibition of the iron-exporting protein ferroportin.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	0-8
33123307-8	2020	ROS induced by iron overload promote necroptosis via a positive feedback mechanism, as on the one hand N-acetylcysteine attenuates the upregulation of RIPK1 and RIPK3 and phosphorylation of RIPK1, RIPK3, and MLKL and on the other hand Nec-1, siRIPK1, or siRIPK3 reduced ROS generation.	Iron	15-19	receptor interacting serine/threonine kinase 1	Homo sapiens	151-156
33123307-8	2020	ROS induced by iron overload promote necroptosis via a positive feedback mechanism, as on the one hand N-acetylcysteine attenuates the upregulation of RIPK1 and RIPK3 and phosphorylation of RIPK1, RIPK3, and MLKL and on the other hand Nec-1, siRIPK1, or siRIPK3 reduced ROS generation.	Iron	15-19	receptor interacting serine/threonine kinase 1	Homo sapiens	190-195
33123307-8	2020	ROS induced by iron overload promote necroptosis via a positive feedback mechanism, as on the one hand N-acetylcysteine attenuates the upregulation of RIPK1 and RIPK3 and phosphorylation of RIPK1, RIPK3, and MLKL and on the other hand Nec-1, siRIPK1, or siRIPK3 reduced ROS generation.	Iron	15-19	proprotein convertase subtilisin/kexin type 1	Homo sapiens	235-240
33123307-9	2020	In summary, iron overload induced necroptosis of osteoblastic cells in vitro, which is mediated, at least in part, through the RIPK1/RIPK3/MLKL pathway.	Iron	12-16	receptor interacting serine/threonine kinase 1	Homo sapiens	127-132
32989163-0	2020	Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates.	Iron	59-63	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	75-78
33046755-0	2020	Toll-like receptor 4 (TLR4) expression is correlated with T2* iron deposition in response to doxorubicin treatment: cardiotoxicity risk assessment.	Iron	62-66	toll like receptor 4	Homo sapiens	0-20
33046755-0	2020	Toll-like receptor 4 (TLR4) expression is correlated with T2* iron deposition in response to doxorubicin treatment: cardiotoxicity risk assessment.	Iron	62-66	toll like receptor 4	Homo sapiens	22-26
33046755-3	2020	Early identification of the presence of iron deposits and genetic and environmental triggers that predispose individuals to increased risk of Dox-induced CTX (e.g., overexpression of Toll-like receptor 4 (TLR4)) will enable the early implementation of countermeasure therapy, which will improve the patient"s chance of survival.	Iron	40-44	toll like receptor 4	Homo sapiens	183-203
33046755-3	2020	Early identification of the presence of iron deposits and genetic and environmental triggers that predispose individuals to increased risk of Dox-induced CTX (e.g., overexpression of Toll-like receptor 4 (TLR4)) will enable the early implementation of countermeasure therapy, which will improve the patient"s chance of survival.	Iron	40-44	toll like receptor 4	Homo sapiens	205-209
33046755-7	2020	We subsequently correlated serum TLR4 levels in our cohort with myocardial iron overload using the cardiac magnetic resonance (CMR) T2* technique, the ventricular function (% ejection fraction, %EF) and serum transferrin levels.	Iron	75-79	toll like receptor 4	Homo sapiens	33-37
33046755-12	2020	We concluded that there is a direct relationship between Dox-induced CTX (indicated by elevated serum TLR4) and the times (ms) for T2* (decreases in which correspond to immediate and rapid iron overload).	Iron	189-193	toll like receptor 4	Homo sapiens	102-106
31912417-5	2020	The results showed that the contents of malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2), and the activity of nitric oxide synthase (iNOS) were increased in excessive iron-fed sheep.	Iron	185-189	nitric oxide synthase, inducible	Ovis aries	151-155
31912417-7	2020	The iNOS mRNA expression declined in excessive iron-fed sheep, indicating that down-regulation is likely to occur at the transcription level, which is consistent with the studies of iron blockades iNOS transcription.	Iron	47-51	nitric oxide synthase, inducible	Ovis aries	4-8
31912417-7	2020	The iNOS mRNA expression declined in excessive iron-fed sheep, indicating that down-regulation is likely to occur at the transcription level, which is consistent with the studies of iron blockades iNOS transcription.	Iron	47-51	nitric oxide synthase, inducible	Ovis aries	197-201
31912417-7	2020	The iNOS mRNA expression declined in excessive iron-fed sheep, indicating that down-regulation is likely to occur at the transcription level, which is consistent with the studies of iron blockades iNOS transcription.	Iron	182-186	nitric oxide synthase, inducible	Ovis aries	4-8
31912417-7	2020	The iNOS mRNA expression declined in excessive iron-fed sheep, indicating that down-regulation is likely to occur at the transcription level, which is consistent with the studies of iron blockades iNOS transcription.	Iron	182-186	nitric oxide synthase, inducible	Ovis aries	197-201
32480040-0	2020	Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.	Iron	59-63	acireductone dioxygenase 1	Homo sapiens	0-26
32480040-0	2020	Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.	Iron	59-63	acireductone dioxygenase 1	Homo sapiens	28-32
32480040-0	2020	Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.	Iron	93-97	acireductone dioxygenase 1	Homo sapiens	0-26
32480040-0	2020	Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.	Iron	93-97	acireductone dioxygenase 1	Homo sapiens	28-32
32480040-1	2020	The iron-containing protein, acireductone dioxygenase 1 (ADI1), is a dioxygenase important for polyamine synthesis and proliferation.	Iron	4-8	acireductone dioxygenase 1	Homo sapiens	29-55
32480040-1	2020	The iron-containing protein, acireductone dioxygenase 1 (ADI1), is a dioxygenase important for polyamine synthesis and proliferation.	Iron	4-8	acireductone dioxygenase 1	Homo sapiens	57-61
32480040-2	2020	Using differential proteomics, the studies herein demonstrated that ADI1 was significantly down-regulated by cellular iron depletion.	Iron	118-122	acireductone dioxygenase 1	Homo sapiens	68-72
32480040-3	2020	This is important, since ADI1 contains a non-heme, iron-binding site critical for its activity.	Iron	51-55	acireductone dioxygenase 1	Homo sapiens	25-29
32480040-4	2020	Examination of multiple human cell-types demonstrated a significant decrease in ADI1 mRNA and protein after incubation with iron chelators.	Iron	124-128	acireductone dioxygenase 1	Homo sapiens	80-84
32480040-5	2020	The decrease in ADI1 after iron depletion was reversible upon incubation of cells with the iron salt, ferric ammonium citrate (FAC).	Iron	27-31	acireductone dioxygenase 1	Homo sapiens	16-20
32480040-6	2020	A significant decrease in ADI1 mRNA levels was observed after 14 h of iron depletion.	Iron	70-74	acireductone dioxygenase 1	Homo sapiens	26-30
32480040-7	2020	In contrast, the chelator-mediated reduction in ADI1 protein occurred earlier after 10 h of iron depletion, suggesting additional post-transcriptional regulation.	Iron	92-96	acireductone dioxygenase 1	Homo sapiens	48-52
32480040-8	2020	The proteasome inhibitor, MG-132, prevented the iron chelator-mediated decrease in ADI1 expression, while the lysosomotropic agent, chloroquine, had no effect.	Iron	48-52	acireductone dioxygenase 1	Homo sapiens	83-87
32634119-0	2020	Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia.	Iron	17-21	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	56-60
32712297-3	2020	In the current study, we elaborate on the direct partners in calibrating the capability of FPN in exporting iron out of cells, such as ceruloplasmin (CP), hephaestin (HP) and poly(rC)-binding protein 2 (PCBP2).	Iron	108-112	ceruloplasmin	Homo sapiens	135-148
33061378-10	2020	The transfected cells showed higher intracellular iron accumulation and resulted in a lower MR T2-weighted imaging (T2WI) intensity, suggesting that the transfection of AFP@Fth could be a potential strategy for early diagnosis of liver cancer.	Iron	50-54	ferritin heavy chain 1	Homo sapiens	173-176
32998264-2	2020	BMP6 controls expression of the liver hormone, hepcidin, and thereby plays a crucial role in regulating iron homeostasis.	Iron	104-108	bone morphogenetic protein 6	Mus musculus	0-4
32998264-3	2020	BMP6 gene transcriptional regulation in liver is largely unknown, but would be of great help to externally modulate iron load in pathologic conditions.	Iron	116-120	bone morphogenetic protein 6	Mus musculus	0-4
32542311-0	2020	Fetal liver hepcidin secures iron stores in utero.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	12-20
32542311-1	2020	In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling respectively.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	40-48
32542311-1	2020	In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling respectively.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	50-54
32542311-1	2020	In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling respectively.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	40-48
32542311-1	2020	In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling respectively.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	50-54
32542311-1	2020	In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling respectively.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	40-48
32542311-1	2020	In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling respectively.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	50-54
32542311-2	2020	Impaired HAMP expression or FPN responsiveness to HAMP result in iron overload.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	9-13
32542311-2	2020	Impaired HAMP expression or FPN responsiveness to HAMP result in iron overload.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	50-54
32542311-3	2020	HAMP is also expressed in the fetal liver but its role in controlling fetal iron stores is not understood.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-4
32542311-4	2020	To address this question in a manner that safeguards against the confounding effects of altered maternal iron homeostasis, we generated fetuses harbouring a paternally-inherited ubiquitous knock-in of the HAMP-resistant fpnC326Y.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	205-209
32542311-7	2020	Thus, fetal liver HAMP operates cell-autonomously to increase fetal liver iron stores.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	18-22
32583831-8	2020	The addition of UL iron to the diet significantly reduced the expression of tight junction proteins Claudin-1, Occludin, and ZO-1 in the duodenal mucosa of weaned piglets (P < 0.05).	Iron	19-23	claudin 1	Sus scrofa	100-109
32583831-8	2020	The addition of UL iron to the diet significantly reduced the expression of tight junction proteins Claudin-1, Occludin, and ZO-1 in the duodenal mucosa of weaned piglets (P < 0.05).	Iron	19-23	occludin	Sus scrofa	111-119
32583831-8	2020	The addition of UL iron to the diet significantly reduced the expression of tight junction proteins Claudin-1, Occludin, and ZO-1 in the duodenal mucosa of weaned piglets (P < 0.05).	Iron	19-23	zonula occludens 1	Sus scrofa	125-129
32962732-0	2020	Hepcidin is described as the master regulator of iron: could its removal by CRRT lead to iron dysmetabolism in the critically ill?	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
32962732-0	2020	Hepcidin is described as the master regulator of iron: could its removal by CRRT lead to iron dysmetabolism in the critically ill?	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
33005455-5	2020	Results: The most important promoters of iron absorption in foods are ascorbic acid, lactic acid (produced by fermentation), meat factors in animal meat, the presence of heme iron, and alcohol which stimulate iron uptake by inhibition of hepcidin expression.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	238-246
33005455-8	2020	Turmeric/curcumin may stimulate iron uptake through a decrease in hepcidin expression and inhibit uptake by complex formation with iron, but the net effect has not been clarified.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	66-74
33005455-9	2020	Conclusions: In haemochromatosis, iron absorption is enhanced due to a decreased expression of hepcidin.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	95-103
32432367-1	2020	The design of biomimetic model complexes for the cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO) is reported, where the 3-His coordination of the iron ion is simulated by three pyrazole donors of a trispyrazolyl borate ligand (Tp) and protected cysteine and cysteamine represent substrate ligands.	Iron	158-162	2-aminoethanethiol dioxygenase	Homo sapiens	104-107
33013818-5	2020	Moreover, Aft1 and Aft2 activate the expression of Cth2, an mRNA-binding protein that limits the expression of genes encoding for iron-containing proteins or that participate in iron-using processes.	Iron	130-134	Tis11p	Saccharomyces cerevisiae S288C	51-55
33013818-5	2020	Moreover, Aft1 and Aft2 activate the expression of Cth2, an mRNA-binding protein that limits the expression of genes encoding for iron-containing proteins or that participate in iron-using processes.	Iron	178-182	Tis11p	Saccharomyces cerevisiae S288C	51-55
33013818-6	2020	Cth2 contributes to prioritize iron utilization in particular pathways over other highly iron-consuming and non-essential processes including mitochondrial respiration.	Iron	31-35	Tis11p	Saccharomyces cerevisiae S288C	0-4
33013818-6	2020	Cth2 contributes to prioritize iron utilization in particular pathways over other highly iron-consuming and non-essential processes including mitochondrial respiration.	Iron	89-93	Tis11p	Saccharomyces cerevisiae S288C	0-4
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	8-12	Yap5p	Saccharomyces cerevisiae S288C	31-35
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	8-12	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	37-41
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	Yap5p	Saccharomyces cerevisiae S288C	31-35
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	37-41
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	Yap5p	Saccharomyces cerevisiae S288C	31-35
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	37-41
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	Yap5p	Saccharomyces cerevisiae S288C	31-35
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	37-41
32921750-8	2020	Viral disease, and in particular SARS-CoV19, could induce activation of the hepcidin pathway, which in turn is responsible for an increase in the iron load.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	76-84
32416394-6	2020	The O-, C-, S-, and Fe-containing functional groups on the surface of MoS2@MBC led to an electrostatic attraction of Cd(II) and strong Cd-S complexation.	Iron	20-22	CDP-diacylglycerol synthase 1	Homo sapiens	135-139
32527800-6	2020	CONCLUSIONS: SGLT2 inhibition is associated, directly or indirectly, with multiple biological effects, including changes in markers of cardiomyocyte contraction/relaxation, iron handling, and other metabolic and renal targets.	Iron	173-177	solute carrier family 5 member 2	Homo sapiens	13-18
32316799-8	2020	Conclusions: HA acclimatization suppresses hepcidin expression to increase iron availability during severe energy deficit.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	43-51
32810738-4	2020	Hypoxic primary human macrophages reduced intracellular free iron and increased ferritin expression, including mitochondrial ferritin (FTMT), to store iron.	Iron	151-155	ferritin mitochondrial	Homo sapiens	111-133
32810738-4	2020	Hypoxic primary human macrophages reduced intracellular free iron and increased ferritin expression, including mitochondrial ferritin (FTMT), to store iron.	Iron	151-155	ferritin mitochondrial	Homo sapiens	135-139
32810738-8	2020	FTMT and ferritin heavy chain (FTH) cooperated to protect macrophages from RSL-3-induced ferroptosis under hypoxia as this form of cell death is linked to iron metabolism.	Iron	155-159	ferritin mitochondrial	Homo sapiens	0-4
32810738-8	2020	FTMT and ferritin heavy chain (FTH) cooperated to protect macrophages from RSL-3-induced ferroptosis under hypoxia as this form of cell death is linked to iron metabolism.	Iron	155-159	ferritin heavy chain 1	Homo sapiens	9-29
32810738-8	2020	FTMT and ferritin heavy chain (FTH) cooperated to protect macrophages from RSL-3-induced ferroptosis under hypoxia as this form of cell death is linked to iron metabolism.	Iron	155-159	ferritin heavy chain 1	Homo sapiens	31-34
32438400-5	2020	In addition to counteracting hepcidin driven iron limitation for erythropoiesis, we found that the combination of KY1070 and recombinant human EPO improved the erythroid response compared to either monotherapy in a qualitative and quantitative manner.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	29-37
32438400-7	2020	Moreover, we found that suppression of hepcidin via KY1070 modulates ferroportin expression on erythroid precursor cells, thereby lowering potentially toxic free intracellular iron levels and by accelerating erythroid output as reflected by increased maturation of erythrocyte progenitors.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	39-47
32810223-4	2020	Hepcidin is the key iron regulator in organisms; however, no studies have investigated its role in maintaining neutrophil iron homeostasis or characterized neutrophil function in patients with hereditary hemochromatosis (HH), a common iron overload genetic disorder that results from a defect in hepcidin production.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	0-8
32810223-7	2020	In contrast, in both HH mouse models and HH patients, the lack of hepcidin expression protects neutrophils from toxic iron accumulation.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	66-74
32908636-6	2020	HO-1 activity leads to production of carbon monoxide (CO), free iron ion, and biliverdin; the latter is promptly reduced to bilirubin.	Iron	64-68	heme oxygenase 1	Homo sapiens	0-4
32601061-0	2020	Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates.	Iron	32-36	2-aminoethanethiol dioxygenase	Homo sapiens	47-69
32601061-1	2020	Cysteamine dioxygenase (ADO) has been reported to exhibit two distinct biological functions with a nonheme iron center.	Iron	107-111	2-aminoethanethiol dioxygenase	Homo sapiens	0-22
32601061-1	2020	Cysteamine dioxygenase (ADO) has been reported to exhibit two distinct biological functions with a nonheme iron center.	Iron	107-111	2-aminoethanethiol dioxygenase	Homo sapiens	24-27
32325343-6	2020	We further investigated the mechanism underlying TCDD-induced hepatocyte apoptosis through apoptosis polymerase chain reaction array, and found that a crucial apoptosis-related gene, cell death-inducing DFF45-like effector b (Cideb), was significantly increased in primary hepatocytes from TCDD-exposed mice, and accompanied by liver iron deposition in hepcidin knockout mice.	Iron	334-338	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	Mus musculus	226-231
32325343-7	2020	Therefore, Cideb depletion could effectively attenuated TCDD or iron induced cell death related genes expression.	Iron	64-68	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	Mus musculus	11-16
32325343-8	2020	In conclusion, our results showed that iron-induced Cideb expression played a critical role in promoting TCDD-induced hepatocyte apoptosis and liver fibrosis, which provide a novel mechanism for understanding TCDD-induced liver injury.	Iron	39-43	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	Mus musculus	52-57
32170997-7	2020	These results suggest that miR-122 agomir can prevent the accumulation of hepatic iron induced by MC-LR, which may be related to the regulation of hepcidin by BMP/SMAD and IL-6/STAT signaling pathways.	Iron	82-86	microRNA 122	Mus musculus	27-34
32752233-1	2020	Hepatic hepcidin is a well-known major iron regulator and has been reported to be closely related to hepatitis C virus (HCV) replication.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	8-16
32756964-11	2020	The results indicated that both oral administration and intramuscular injection with iron promoted intestinal development and epithelial maturation in suckling piglets, and that the effects of iron may be independent of wnt/beta-catenin signaling.	Iron	85-89	catenin beta 1	Homo sapiens	224-236
32450003-0	2020	Reduced Iron Export Associated with Hepcidin Resistance Can Explain the Iron Overload Spectrum in Ferroportin Disease.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	36-44
32450003-0	2020	Reduced Iron Export Associated with Hepcidin Resistance Can Explain the Iron Overload Spectrum in Ferroportin Disease.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	36-44
32450003-3	2020	The aim of this study was to assess if reduced iron export also confers hepcidin resistance and causes iron overload in FD associated with the R178Q variant.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	72-80
32450003-6	2020	The hepcidin-ferroportin axis was assessed by ferritin/hepcidin correlation in patients with different iron storage diseases.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	4-12
32450003-9	2020	Regression analysis of serum hepcidin and ferritin in patients with iron overload are compatible with hepcidin deficiency in HFE hemochromatosis and hepcidin resistance in R178Q FD.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	29-37
32450003-9	2020	Regression analysis of serum hepcidin and ferritin in patients with iron overload are compatible with hepcidin deficiency in HFE hemochromatosis and hepcidin resistance in R178Q FD.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	102-110
32450003-9	2020	Regression analysis of serum hepcidin and ferritin in patients with iron overload are compatible with hepcidin deficiency in HFE hemochromatosis and hepcidin resistance in R178Q FD.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	102-110
32798434-0	2020	[Change of Hepcidin in Patients with Iron Overload at the Tibet Plateau].	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	11-19
32798434-1	2020	OBJECTIVE: To explore the possible etiological factors of iron overload through detecting plasma hepcidin level of adult males at Tibet plateau.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	97-105
32798434-6	2020	RESULTS: The plasma hepcidin of iron overload group was significantly higher than that of the non-iron overload group [93.69 (65.57-133.92) ng/ml vs 63.93 (40.01-90.65) ng/ml] (P=0.005).	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	20-28
32798434-6	2020	RESULTS: The plasma hepcidin of iron overload group was significantly higher than that of the non-iron overload group [93.69 (65.57-133.92) ng/ml vs 63.93 (40.01-90.65) ng/ml] (P=0.005).	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	20-28
32732975-2	2020	Here, we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	62-70
32732975-5	2020	Interestingly, we found that canonical signaling pathways that regulate iron, including the Bmp/Smad and IL-6/Jak2/Stat3 pathways, play indispensable roles in mediating AUR"s effects.	Iron	72-76	Janus kinase 2	Mus musculus	110-114
32586947-10	2020	Despite our previous finding of diminished accumulation of the ferritin-bound iron in the Mcoln1 -/- brain, we report no significant changes in expression of the cytosolic iron reporters, suggesting that iron-handling deficits in MLIV occur in the lysosomes and do not involve broad iron deficiency.	Iron	78-82	mucolipin 1	Mus musculus	90-96
32724060-7	2020	Most importantly, one-third concentrations of E2-a from PLGA-Fe-E2 based on the release profile of E2-a was equally effective in inhibiting metacestode growth as E2-a treated group, supporting efficacy and bioavailability of a drug.	Iron	61-63	transcription factor 3	Mus musculus	46-50
32724060-7	2020	Most importantly, one-third concentrations of E2-a from PLGA-Fe-E2 based on the release profile of E2-a was equally effective in inhibiting metacestode growth as E2-a treated group, supporting efficacy and bioavailability of a drug.	Iron	61-63	transcription factor 3	Mus musculus	99-103
32724060-7	2020	Most importantly, one-third concentrations of E2-a from PLGA-Fe-E2 based on the release profile of E2-a was equally effective in inhibiting metacestode growth as E2-a treated group, supporting efficacy and bioavailability of a drug.	Iron	61-63	transcription factor 3	Mus musculus	99-103
32623334-2	2020	We hypothesize that abnormal iron accumulation is a common thread underlying the emergence of the hallmarks of PD, namely mitochondrial dysfunction and alpha-synuclein accumulation.	Iron	29-33	synuclein alpha	Homo sapiens	152-167
32623334-3	2020	We investigated the powerful action of the main iron regulator hepcidin in the brain.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	63-71
32623334-5	2020	Hepcidin protected rotenone-induced mitochondrial deficits by reducing cellular and mitochondrial iron accumulation.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
32623334-6	2020	In addition, hepcidin decreased alpha-synuclein accumulation and promoted clearance of alpha-synuclein through decreasing iron content that leads to activation of autophagy.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	13-21
32623334-6	2020	In addition, hepcidin decreased alpha-synuclein accumulation and promoted clearance of alpha-synuclein through decreasing iron content that leads to activation of autophagy.	Iron	122-126	synuclein alpha	Homo sapiens	87-102
32623334-7	2020	Our results not only pinpoint a critical role of iron-overload in the pathogenesis of PD but also demonstrate that targeting brain iron levels through hepcidin is a promising therapeutic direction.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	151-159
32709979-3	2021	We defined iron-limited erythropoiesis by a RET-He <5th percentile lower reference interval (<28 pg).	Iron	11-15	ret proto-oncogene	Homo sapiens	44-47
32718025-3	2020	Recently, several studies have identified intricate and complicated interplay between ferroptosis, ionizing radiation (IR), ATM (ataxia-telangiectasia mutated)/ATR (ATM and Rad3-related), and tumor suppressor p53, which signifies the participation of the DNA damage response (DDR) in iron-related cell death.	Iron	284-288	ATM serine/threonine kinase	Homo sapiens	124-158
32718025-3	2020	Recently, several studies have identified intricate and complicated interplay between ferroptosis, ionizing radiation (IR), ATM (ataxia-telangiectasia mutated)/ATR (ATM and Rad3-related), and tumor suppressor p53, which signifies the participation of the DNA damage response (DDR) in iron-related cell death.	Iron	284-288	ATM serine/threonine kinase	Homo sapiens	124-127
32793263-1	2020	The present work describes the effects on iron homeostasis when copper transport was deregulated in Arabidopsis thaliana by overexpressing high affinity copper transporters COPT1 and COPT3 (COPTOE ).	Iron	42-46	copper transporter 3	Arabidopsis thaliana	183-188
32152203-6	2020	RESULTS: By investigating PCPG cells with low SDHB levels, we show that pseudohypoxia resulted in elevated expression of iron transport proteins, including transferrin (TF), transferrin receptor 2 (TFR2) and the divalent metal transporter 1 (SLC11A2; DMT1), leading to iron accumulation.	Iron	121-125	solute carrier family 11 member 2	Homo sapiens	242-249
32152203-6	2020	RESULTS: By investigating PCPG cells with low SDHB levels, we show that pseudohypoxia resulted in elevated expression of iron transport proteins, including transferrin (TF), transferrin receptor 2 (TFR2) and the divalent metal transporter 1 (SLC11A2; DMT1), leading to iron accumulation.	Iron	121-125	solute carrier family 11 member 2	Homo sapiens	251-255
31693761-9	2020	Inhibition of the iron transporter DMT1 protected IMG cells against Abeta-induced inflammation.	Iron	18-22	doublesex and mab-3 related transcription factor 1	Homo sapiens	35-39
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	53-57	doublesex and mab-3 related transcription factor 1	Homo sapiens	124-128
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	138-142	doublesex and mab-3 related transcription factor 1	Homo sapiens	124-128
32637390-3	2020	The tricarbonyl (eta4-cyclopentadienone) iron complex catalyzed dehydrogenative cyclization, releasing water and hydrogen gas as by-products.	Iron	41-45	gastrin	Homo sapiens	122-125
32083771-0	2020	DMT1 Inhibitors Kill Cancer Stem Cells by Blocking Lysosomal Iron Translocation.	Iron	61-65	solute carrier family 11 member 2	Homo sapiens	0-4
32083771-3	2020	Here, inhibitors of the divalent metal transporter 1 (DMT1) have been identified that selectively target CSC by blocking lysosomal iron translocation.	Iron	131-135	solute carrier family 11 member 2	Homo sapiens	24-52
32083771-3	2020	Here, inhibitors of the divalent metal transporter 1 (DMT1) have been identified that selectively target CSC by blocking lysosomal iron translocation.	Iron	131-135	solute carrier family 11 member 2	Homo sapiens	54-58
32517787-4	2020	RESULTS: Of the plasma proteins implicated in iron and heme metabolism, hemoglobin subunit beta (p = 0.001) was significantly increased in AD compared to CN individuals.	Iron	46-50	hemoglobin subunit beta	Homo sapiens	72-95
32379419-0	2020	alpha-Synuclein regulates iron homeostasis via preventing parkin-mediated DMT1 ubiquitylation in Parkinson"s disease models.	Iron	26-30	synuclein alpha	Homo sapiens	0-15
32379419-0	2020	alpha-Synuclein regulates iron homeostasis via preventing parkin-mediated DMT1 ubiquitylation in Parkinson"s disease models.	Iron	26-30	solute carrier family 11 member 2	Homo sapiens	74-78
32379419-2	2020	alpha-synuclein (alpha-Syn) serves as a ferrireductase and iron-binding protein which is supposed to be linked with iron metabolism, little is known how alpha-Syn affects iron homeostasis in PD.	Iron	59-63	synuclein alpha	Homo sapiens	0-15
32379419-2	2020	alpha-synuclein (alpha-Syn) serves as a ferrireductase and iron-binding protein which is supposed to be linked with iron metabolism, little is known how alpha-Syn affects iron homeostasis in PD.	Iron	59-63	synuclein alpha	Homo sapiens	17-26
32379419-2	2020	alpha-synuclein (alpha-Syn) serves as a ferrireductase and iron-binding protein which is supposed to be linked with iron metabolism, little is known how alpha-Syn affects iron homeostasis in PD.	Iron	116-120	synuclein alpha	Homo sapiens	0-15
32379419-2	2020	alpha-synuclein (alpha-Syn) serves as a ferrireductase and iron-binding protein which is supposed to be linked with iron metabolism, little is known how alpha-Syn affects iron homeostasis in PD.	Iron	116-120	synuclein alpha	Homo sapiens	17-26
32379419-2	2020	alpha-synuclein (alpha-Syn) serves as a ferrireductase and iron-binding protein which is supposed to be linked with iron metabolism, little is known how alpha-Syn affects iron homeostasis in PD.	Iron	116-120	synuclein alpha	Homo sapiens	0-15
32379419-2	2020	alpha-synuclein (alpha-Syn) serves as a ferrireductase and iron-binding protein which is supposed to be linked with iron metabolism, little is known how alpha-Syn affects iron homeostasis in PD.	Iron	116-120	synuclein alpha	Homo sapiens	17-26
32379419-3	2020	Based on our previous findings that up-regulation of divalent metal transporter 1 (DMT1) accounted for the nigral iron accumulation in PD, this raised the question whether alpha-Syn disturbed iron homeostasis by modulating DMT1 expression.	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	53-81
32379419-3	2020	Based on our previous findings that up-regulation of divalent metal transporter 1 (DMT1) accounted for the nigral iron accumulation in PD, this raised the question whether alpha-Syn disturbed iron homeostasis by modulating DMT1 expression.	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	83-87
32379419-6	2020	Our findings revealed that alpha-Syn affected brain iron homeostasis through modulating DMT1 protein stability and altering cellular iron uptake, which might uncover a direct evidence for the involvement of alpha-Syn in the iron metabolism dysfunction and provide insight into the further understanding of PD-associated nigral iron deposition.	Iron	52-56	synuclein, alpha	Mus musculus	27-36
32379419-6	2020	Our findings revealed that alpha-Syn affected brain iron homeostasis through modulating DMT1 protein stability and altering cellular iron uptake, which might uncover a direct evidence for the involvement of alpha-Syn in the iron metabolism dysfunction and provide insight into the further understanding of PD-associated nigral iron deposition.	Iron	52-56	synuclein, alpha	Mus musculus	207-216
32379419-6	2020	Our findings revealed that alpha-Syn affected brain iron homeostasis through modulating DMT1 protein stability and altering cellular iron uptake, which might uncover a direct evidence for the involvement of alpha-Syn in the iron metabolism dysfunction and provide insight into the further understanding of PD-associated nigral iron deposition.	Iron	133-137	synuclein, alpha	Mus musculus	27-36
32379419-6	2020	Our findings revealed that alpha-Syn affected brain iron homeostasis through modulating DMT1 protein stability and altering cellular iron uptake, which might uncover a direct evidence for the involvement of alpha-Syn in the iron metabolism dysfunction and provide insight into the further understanding of PD-associated nigral iron deposition.	Iron	133-137	synuclein, alpha	Mus musculus	27-36
32565850-3	2020	The treatment of human fibroblasts with FE at a dose of 0.5% increased collagen production by up to 170% and inhibited MMP-1 synthesis to 48%, which is likely due to its high antioxidant activity because the WE and GE showed markedly lower effects compared with those of the FE.	Iron	40-42	matrix metallopeptidase 1	Homo sapiens	119-124
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	217-223
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	ferric reduction oxidase 3	Arabidopsis thaliana	250-254
32423859-0	2020	Serum hepcidin levels are related to serum markers for iron metabolism and fibrosis stage in patients with chronic hepatitis B: A cross-sectional study.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	6-14
32274616-0	2020	Influence of oral administration mode on the efficacy of commercial bovine Lactoferrin against iron and inflammatory homeostasis disorders.	Iron	95-99	lactotransferrin	Bos taurus	75-86
32605459-1	2020	Ferroptosis is a type of iron-dependent, non-apoptotic cell death, which is typically induced by the suppression of phospholipid hydroperoxide-glutathione peroxidase (GPX4) activity and a corresponding elevation in lipid peroxidation products.	Iron	25-29	glutathione peroxidase 4	Mus musculus	167-171
31974407-1	2020	BACKGROUND/OBJECTIVES: In overweight and obesity (OW/OB), greater total body fat predicts higher serum hepcidin (SHep) which can impair iron homeostasis and increase risk for iron deficiency (ID).	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	103-111
32105901-0	2020	Hierarchical iron-doped CoP heterostructures self-assembled on copper foam as a bifunctional electrocatalyst for efficient overall water splitting.	Iron	13-17	caspase recruitment domain family member 16	Homo sapiens	24-27
32105901-1	2020	A bifunctional electrocatalyst with peculiarly hierarchical snowflake-like iron-doped CoP heterostructures self-assembled on copper foam (CoFeP/CF) was synthesized via a facile hydrothermal-phosphidation pathway.	Iron	75-79	caspase recruitment domain family member 16	Homo sapiens	86-89
32087292-2	2020	Ceruloplasmin (Cp) is a circulating protein that intersects both these pathways, since its expression is increased during the acute phase response, and the protein acts to lower pro-oxidant iron in cells.	Iron	190-194	ceruloplasmin	Homo sapiens	0-13
32596380-0	2020	Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating Wnt/Beta-Catenin Signaling.	Iron	0-4	catenin beta 1	Rattus norvegicus	98-110
32596380-0	2020	Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating Wnt/Beta-Catenin Signaling.	Iron	64-68	catenin beta 1	Rattus norvegicus	98-110
32596380-2	2020	In this study, we explored the activities of Wnt/beta-catenin signaling in bone tissues with iron accumulation.	Iron	93-97	catenin beta 1	Rattus norvegicus	49-61
32596380-11	2020	Conclusion: The osteoporosis could be caused by iron overload, which reduced the bone mineral density by disrupting the homeostasis of bone formation and absorption and attenuating the Wnt/beta-catenin signaling in bone tissues.	Iron	48-52	catenin beta 1	Rattus norvegicus	189-201
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	113-117
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	transferrin receptor 2	Homo sapiens	150-172
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	transferrin receptor 2	Homo sapiens	173-177
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	198-206
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	207-211
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	hemojuvelin BMP co-receptor	Homo sapiens	214-225
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	hemojuvelin BMP co-receptor	Homo sapiens	226-229
32621410-3	2020	Among these epigenetic regulators, DNA hypermethylation of the promoter region of FPN, TFR2, HAMP, HJV and bone morphogenetic protein 6 (BMP6) genes result in inhibitory effect on the expression of these iron-related gene.	Iron	204-208	transferrin receptor 2	Homo sapiens	87-91
32621410-3	2020	Among these epigenetic regulators, DNA hypermethylation of the promoter region of FPN, TFR2, HAMP, HJV and bone morphogenetic protein 6 (BMP6) genes result in inhibitory effect on the expression of these iron-related gene.	Iron	204-208	hepcidin antimicrobial peptide	Homo sapiens	93-97
32621410-3	2020	Among these epigenetic regulators, DNA hypermethylation of the promoter region of FPN, TFR2, HAMP, HJV and bone morphogenetic protein 6 (BMP6) genes result in inhibitory effect on the expression of these iron-related gene.	Iron	204-208	hemojuvelin BMP co-receptor	Homo sapiens	99-102
32621410-6	2020	Additional reports showed that miRNA can also modulate iron absorption, transport, storage and utilization via downregulation of DMT1, FPN, TFR1, TFR2, Ferritin H and other genes.	Iron	55-59	doublesex and mab-3 related transcription factor 1	Homo sapiens	129-133
32621410-6	2020	Additional reports showed that miRNA can also modulate iron absorption, transport, storage and utilization via downregulation of DMT1, FPN, TFR1, TFR2, Ferritin H and other genes.	Iron	55-59	transferrin receptor 2	Homo sapiens	146-150
32335361-6	2020	Furthermore, remarkable selectivity for C2H5OH against other C1 and C2 products is found for Fe2 dimer anchored on C2N monolayer.	Iron	93-96	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	61-70
32433474-0	2020	Bitumen from the Dead Sea in Early Iron Age Nubia.	Iron	35-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	22-25
31413088-1	2020	In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin that persists for 24 hours, decreasing iron absorption from supplements given later on the same or next day.	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	89-97
31413088-1	2020	In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin that persists for 24 hours, decreasing iron absorption from supplements given later on the same or next day.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	89-97
31413088-1	2020	In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin that persists for 24 hours, decreasing iron absorption from supplements given later on the same or next day.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	89-97
31413088-5	2020	Secondary objectives were to correlate iron absorption with serum hepcidin and iron status parameters.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	66-74
31413088-13	2020	Even if in iron-deficiency anemia hepatic hepcidin expression is strongly suppressed by iron deficiency and erythropoietic drive, the intake of oral iron supplements leads to an acute hepcidin increase for 24 hours.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	42-50
31635639-3	2020	Fe2O3/Fe3O4 heterogeneous microparticles calcined at 200  C for 1 h with absolute ethyl alcohol of 20 mL had the largest saturation magnetization of 90.1 Am2/kg.	Iron	0-5	adrenomedullin 2	Homo sapiens	154-157
32073619-9	2020	Both ferritin (r = -0.41, P = 0.014) and hepcidin (r = -0.42, P = 0.01) concentrations were inversely correlated with ASP-p iron absorption.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	41-49
31585004-10	2020	The quadruple mutants had increased transcription of calcium homeostasis/signaling genes in seedling shoots, and the SAUR41 overexpression lines had decreased transcription of iron homeostasis genes in roots and increased ABA biosynthesis in shoots.	Iron	176-180	SAUR-like auxin-responsive protein family	Arabidopsis thaliana	117-123
32333389-2	2020	Therefore, we aimed to address the developmental expression, organ-specific, and subcellular localization patterns of iron superoxide dismutase FSD1 in Arabidopsis using advanced fluorescence microscopy methods.	Iron	118-122	Fe superoxide dismutase 1	Arabidopsis thaliana	144-148
32372896-1	2020	Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants.	Iron	112-116	glutathione peroxidase 4	Homo sapiens	167-171
32268883-0	2020	Hepcidin gene polymorphisms and iron overload in beta-thalassemia major patients refractory to iron chelating therapy.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	0-8
32268883-3	2020	Hepcidin is a peptide hormone and an important regulator of iron homeostasis, especially in thalassemia.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
32268883-6	2020	This study aimed to analyze the association between three SNPs in promoter of HAMP, c.-582A > G, c.-443C > T, and c.-153C > T, with iron overload in beta-thalassemia major patients.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	78-82
32268883-15	2020	Our findings and others emphasize the role of hepcidin -582A > G polymorphism as a key component of iron homeostasis in these patients.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	46-54
32000000-9	2020	This association could be explained by an increased expression of DMT1, a divalent metal transporter that captures higher levels of iron in deficiency states of this metal.	Iron	132-136	solute carrier family 11 member 2	Homo sapiens	66-70
31851071-0	2020	Reticulocyte Hemoglobin Content (Ret He): A Simple Tool for Evaluation of Iron Status in Childhood Cancer.	Iron	74-78	ret proto-oncogene	Homo sapiens	0-3
31851071-11	2020	A trial of oral iron in patients with low Ret He may be useful to correct the associated anemia.	Iron	16-20	ret proto-oncogene	Homo sapiens	42-45
31346934-2	2020	This study examined the relationship between patient outcomes following aSAH and genetic variants and DNA methylation in the hepcidin gene (HAMP), a key regulator of iron homeostasis.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	125-133
31346934-2	2020	This study examined the relationship between patient outcomes following aSAH and genetic variants and DNA methylation in the hepcidin gene (HAMP), a key regulator of iron homeostasis.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	140-144
32108853-6	2020	Our results tend to suggest that iron inactivates Parkin in SH-SY5Y cells and thereby inhibits the proteasomal degradation of alpha-synuclein, and the accumulated alpha-synuclein causes mitochondrial dysfunction and cell death.	Iron	33-37	synuclein alpha	Homo sapiens	163-178
32391424-2	2020	We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.	Iron	78-82	prominin 2	Homo sapiens	58-67
32391424-2	2020	We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.	Iron	151-155	prominin 2	Homo sapiens	58-67
32391424-2	2020	We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.	Iron	151-155	prominin 2	Homo sapiens	58-67
31973819-1	2020	In previous studies we demonstrated that zinc stimulates iron uptake in intestinal Caco-2 cells via Zinc-PI3K-IRP2-DMT1 axis.	Iron	57-61	doublesex and mab-3 related transcription factor 1	Homo sapiens	115-119
32258920-8	2020	The optimized catalyst of 12.5 wt % Fe/Ce0.4Al0.1Zr0.5O2-delta showed the highest ammonia synthesis rate (2.3 mmol g-1 h-1) achieved to date under mild conditions (464 K, 0.9 MPa) in an electric field among the Fe catalysts reported.	Iron	36-38	H1.5 linker histone, cluster member	Homo sapiens	119-122
32231654-2	2020	Heme oxygenase-1 (HO-1) catalyzes the conversion of heme into biliverdin (BV), iron and carbon monoxide (CO), all of which have been demonstrated to protect cells from various stressors.	Iron	79-83	heme oxygenase 1	Homo sapiens	0-16
32231654-2	2020	Heme oxygenase-1 (HO-1) catalyzes the conversion of heme into biliverdin (BV), iron and carbon monoxide (CO), all of which have been demonstrated to protect cells from various stressors.	Iron	79-83	heme oxygenase 1	Homo sapiens	18-22
32050764-10	2020	The upregulation of transferrin receptor protein 1 (TFRC), one of the candidates related to iron metabolism, in plasma after Kr administration was validated by selected reaction monitoring (SRM) of corresponding peptides.	Iron	92-96	transferrin receptor	Equus caballus	20-50
32050764-10	2020	The upregulation of transferrin receptor protein 1 (TFRC), one of the candidates related to iron metabolism, in plasma after Kr administration was validated by selected reaction monitoring (SRM) of corresponding peptides.	Iron	92-96	transferrin receptor	Equus caballus	52-56
31732474-1	2020	A naphthylamide based fluorescent chemosensor, N,N"-(1,2-phenylene)bis(1-hydroxy-2-naphthamide) (H4L), for detection of Fe3+ and Al3+ cations as well as CN- anion is reported.	Iron	120-124	H4 clustered histone 7	Homo sapiens	97-100
31732474-4	2020	In DMSO solution, H4L showed selective ON-OFF quenching of its 451 nm emission in the presence of Fe3+.	Iron	98-102	H4 clustered histone 7	Homo sapiens	18-21
31816347-6	2020	The Fe-complex treatment caused cell cycle arrest via the activation of ATM-ATR kinase mediated DNA damage response pathway with the compromised expression of CDK1, CDK2 and CyclinB1 protein in Trigonella seedlings.	Iron	4-6	cyclin dependent kinase 1	Homo sapiens	159-163
31816347-6	2020	The Fe-complex treatment caused cell cycle arrest via the activation of ATM-ATR kinase mediated DNA damage response pathway with the compromised expression of CDK1, CDK2 and CyclinB1 protein in Trigonella seedlings.	Iron	4-6	cyclin B1	Homo sapiens	174-182
32373202-0	2020	Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer.	Iron	27-31	transformation related protein 53, pseudogene	Mus musculus	60-63
32373202-4	2020	Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11).	Iron	27-31	transformation related protein 53, pseudogene	Mus musculus	121-124
32373202-4	2020	Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11).	Iron	27-31	transformation related protein 53, pseudogene	Mus musculus	145-148
32373202-4	2020	Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11).	Iron	27-31	transformation related protein 53, pseudogene	Mus musculus	145-148
32373202-8	2020	In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells.	Iron	106-110	transformation related protein 53, pseudogene	Mus musculus	156-159
31236816-7	2020	After 7 weeks, compared with the control group, the zinc and magnesium contents; superoxide dismutase, glutathione peroxidase, and catalase activities; and synaptophysin and Bcl-2 gene expressions in the iron overload group were significantly decreased, whereas the iron, calcium contents, and malondialdehyde contents; TUNEL-positive cell numbers; and Fas and Bax gene expressions were significantly increased.	Iron	204-208	BCL2 associated X, apoptosis regulator	Rattus norvegicus	361-364
31320750-9	2020	Instead of the canonical DNA damage pathways, ATM inhibition rescued ferroptosis by increasing the expression of iron regulators involved in iron storage (ferritin heavy and light chain, FTH1 and FTL) and export (ferroportin, FPN1).	Iron	113-117	ATM serine/threonine kinase	Homo sapiens	46-49
31320750-9	2020	Instead of the canonical DNA damage pathways, ATM inhibition rescued ferroptosis by increasing the expression of iron regulators involved in iron storage (ferritin heavy and light chain, FTH1 and FTL) and export (ferroportin, FPN1).	Iron	141-145	ATM serine/threonine kinase	Homo sapiens	46-49
31320750-10	2020	The coordinated changes of these iron regulators during ATM inhibition resulted in a lowering of labile iron and prevented the iron-dependent ferroptosis.	Iron	33-37	ATM serine/threonine kinase	Homo sapiens	56-59
31320750-10	2020	The coordinated changes of these iron regulators during ATM inhibition resulted in a lowering of labile iron and prevented the iron-dependent ferroptosis.	Iron	104-108	ATM serine/threonine kinase	Homo sapiens	56-59
31320750-10	2020	The coordinated changes of these iron regulators during ATM inhibition resulted in a lowering of labile iron and prevented the iron-dependent ferroptosis.	Iron	104-108	ATM serine/threonine kinase	Homo sapiens	56-59
31320750-12	2020	Genetic depletion of MTF-1 abolished the regulation of iron-regulatory elements by ATM and resensitized the cells to ferroptosis.	Iron	55-59	ATM serine/threonine kinase	Homo sapiens	83-86
31320750-13	2020	Together, we have identified an unexpected ATM-MTF1-Ferritin/FPN1 regulatory axis as novel determinants of ferroptosis through regulating labile iron levels.	Iron	145-149	ATM serine/threonine kinase	Homo sapiens	43-46
31320750-13	2020	Together, we have identified an unexpected ATM-MTF1-Ferritin/FPN1 regulatory axis as novel determinants of ferroptosis through regulating labile iron levels.	Iron	145-149	solute carrier family 40 member 1	Homo sapiens	61-65
32003373-0	2020	Impact of iron- and/or sulfate-reduction on a cis-1,2-dichloroethene and vinyl chloride respiring bacterial consortium: experiments and model-based interpretation.	Iron	10-14	suppressor of cytokine signaling 1	Homo sapiens	46-51
31659405-2	2020	MT-2 decreases the production of hepcidin, a key regulator of iron homeostasis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	33-41
31659405-9	2020	Based on the in vitro data on hepcidin regulation, treatment with MI-461 might be valuable in pathological states of iron metabolism without causing excessive oxidative stress.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	30-38
32096669-1	2021	Background: During pregnancy, iron is transferred from mother to fetus with placental iron transport proteins (Transferrin receptor, Divalent metal transporter/DMT1, ferroportin/FPN1 and Zyklopen).	Iron	30-34	solute carrier family 11 member 2	Homo sapiens	160-164
32096669-1	2021	Background: During pregnancy, iron is transferred from mother to fetus with placental iron transport proteins (Transferrin receptor, Divalent metal transporter/DMT1, ferroportin/FPN1 and Zyklopen).	Iron	30-34	solute carrier family 40 member 1	Homo sapiens	178-182
31899794-3	2020	Aberrantly high circulating ERFE in conditions of stress erythropoiesis, such as in patients with beta-thalassemia, promotes the tissue iron accumulation that substantially contributes to morbidity in these patients.	Iron	136-140	erythroferrone	Homo sapiens	28-32
31899794-9	2020	In summary, we demonstrate that ERFE binds BMP6 directly and with high affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interactions constitute a potential therapeutic tool for iron-loading anemias.	Iron	221-225	bone morphogenetic protein 6	Mus musculus	43-47
31899794-9	2020	In summary, we demonstrate that ERFE binds BMP6 directly and with high affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interactions constitute a potential therapeutic tool for iron-loading anemias.	Iron	221-225	bone morphogenetic protein 6	Mus musculus	159-163
32053985-0	2020	Bu-M-P-ing Iron: How BMP Signaling Regulates Muscle Growth and Regeneration.	Iron	11-15	bone morphogenetic protein 1	Homo sapiens	21-24
31911438-10	2020	The identification of the NFU1 partner proteins reported here more clearly defines the role of NFU1 in Fe-S client protein maturation in Arabidopsis chloroplasts among other SUF components.	Iron	103-105	NFU domain protein 1	Arabidopsis thaliana	26-30
31911438-10	2020	The identification of the NFU1 partner proteins reported here more clearly defines the role of NFU1 in Fe-S client protein maturation in Arabidopsis chloroplasts among other SUF components.	Iron	103-105	NFU domain protein 1	Arabidopsis thaliana	95-99
32023254-7	2020	Additionally, the LIP was raised along with an elevated mRNA expression of ferritin and HO-1, as also iron exporters NRAMP-1 and Fpn-1.	Iron	102-106	solute carrier family 40 member 1	Homo sapiens	129-134
32023254-9	2020	However, enhancement of the iron exporters (NRAMP-1 and Fpn-1) defied the classical Ferritinlow/Ferroportinhigh phenotype of alternatively activated macrophages.	Iron	28-32	solute carrier family 40 member 1	Homo sapiens	56-61
32099733-5	2020	The activities of caspase-3, caspase-8, and caspase-9 increased with increasing concentration of the nanoparticles indicating that activities of caspase can be activated by iron nanoparticles.	Iron	173-177	caspase 9	Homo sapiens	44-53
31724192-5	2020	In 58 individuals, who underwent oral iron challenge, carriage of the p.L390 M variant was associated with higher transferrin saturation and lower hepcidin release.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	147-155
31724192-8	2020	In mice, Nmbr was induced by chronic dietary iron overload in the liver, gut, pancreas, spleen, and skeletal muscle, while Nmb was downregulated in gut, pancreas and spleen.	Iron	45-49	neuromedin B	Mus musculus	9-12
31802376-0	2020	Investigation of PIC1 (permease in chloroplasts 1) gene"s role in iron homeostasis: bioinformatics and expression analyses in tomato and sorghum.	Iron	66-70	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	17-21
31802376-2	2020	Permease in chloroplast 1 (PIC1) is the first protein determined in the chloroplast playing a role iron homeostasis.	Iron	99-103	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	27-31
31802376-4	2020	Based on the gene ontology database, 21 GO terms were found related to the PIC1 gene, most of which were involved in iron hemostasis and transport.	Iron	117-121	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	75-79
31802376-9	2020	Consequently, these results may contribute to the understanding of the PIC1 gene in iron transport and homeostasis in plants.	Iron	84-88	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	71-75
31866335-3	2020	Molecular mechanism of ferroptosis induction involved suppression of the phospholipid glutathione peroxidase 4 (GPX4) and further intracellular accumulation of lipid reactive oxygen species (ROS), a process in which iron is involved; either via inhibition of system Xc- (cystine/glutamate antiporter) or direct inhibition of GPX4.	Iron	216-220	glutathione peroxidase 4	Homo sapiens	325-329
31961032-1	2020	The jumonji domain-containing protein 6 (JMJD6) is a Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non-histone peptides.	Iron	53-59	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	4-39
31961032-1	2020	The jumonji domain-containing protein 6 (JMJD6) is a Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non-histone peptides.	Iron	53-59	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	41-46
31655016-2	2020	ERFE suppresses hepatic synthesis of the master iron-regulatory hormone, hepcidin.	Iron	48-52	erythroferrone	Homo sapiens	0-4
31655016-2	2020	ERFE suppresses hepatic synthesis of the master iron-regulatory hormone, hepcidin.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	73-81
31655016-11	2020	The ERFE assay is a sensitive means to investigate the connection between iron metabolism and erythropoiesis in humans, and to detect ESA abuse in the anti-doping field.	Iron	74-78	erythroferrone	Homo sapiens	4-8
32069222-1	2020	INTRODUCTION: Hepcidin is an acute-phase protein and a key regulator of iron homeostasis.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	14-22
31585485-6	2020	Only the female group reported significant associations between peripheral markers of iron metabolism and Glx:tCr concentration: (1) Right dorsolateral prefrontal cortex Glx:tCr associated positively with serum transferrin (r=0.60,p=0.006) and negatively with transferrin saturation (r=-0.62, p=0.004) and (2) Right frontal white matter Glx:tCr associated negatively with iron concentration (r=-0.59, p=0.008) and transferrin saturation (r=-0.65, p=0.002).	Iron	86-90	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	110-113
31585485-7	2020	Our results support associations between iron metabolism and our proxy for in vivo glutamate concentration (Glx:tCr).	Iron	41-45	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	112-115
31442326-0	2020	Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in MPTP-induced Parkinson"s disease in mice.	Iron	29-33	lactotransferrin	Mus musculus	0-11
31442326-5	2020	Lf exists mainly in two forms: iron-free-lactoferrin (apo-Lf) and iron-saturated-lactoferrin (holo-Lf).	Iron	31-35	lactotransferrin	Mus musculus	0-2
31442326-5	2020	Lf exists mainly in two forms: iron-free-lactoferrin (apo-Lf) and iron-saturated-lactoferrin (holo-Lf).	Iron	31-35	lactotransferrin	Mus musculus	41-52
31442326-8	2020	In the central nervous system, Lf antagonized 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced DA depletion in the striatum, iron deposition, oxidative and apoptotic processes in the SN.	Iron	136-140	lactotransferrin	Mus musculus	31-33
31442326-9	2020	Lf treatment down-regulated iron import protein divalent metal transporter1 (DMT1) and up-regulated iron export protein ferroportin1 (Fpn1), attenuating MPTP induced accumulation of nigral iron level.	Iron	28-32	lactotransferrin	Mus musculus	0-2
31442326-9	2020	Lf treatment down-regulated iron import protein divalent metal transporter1 (DMT1) and up-regulated iron export protein ferroportin1 (Fpn1), attenuating MPTP induced accumulation of nigral iron level.	Iron	100-104	lactotransferrin	Mus musculus	0-2
31442326-9	2020	Lf treatment down-regulated iron import protein divalent metal transporter1 (DMT1) and up-regulated iron export protein ferroportin1 (Fpn1), attenuating MPTP induced accumulation of nigral iron level.	Iron	100-104	lactotransferrin	Mus musculus	0-2
31442326-10	2020	In the peripheral system, Lf alleviated MPTP-induced increases in serum iron and ferritin, and decreases in serum total iron binding capacity (TIBC), loss of spleen weight, and reduction of spleen iron content.	Iron	72-76	lactotransferrin	Mus musculus	26-28
31442326-10	2020	In the peripheral system, Lf alleviated MPTP-induced increases in serum iron and ferritin, and decreases in serum total iron binding capacity (TIBC), loss of spleen weight, and reduction of spleen iron content.	Iron	120-124	lactotransferrin	Mus musculus	26-28
31442326-10	2020	In the peripheral system, Lf alleviated MPTP-induced increases in serum iron and ferritin, and decreases in serum total iron binding capacity (TIBC), loss of spleen weight, and reduction of spleen iron content.	Iron	120-124	lactotransferrin	Mus musculus	26-28
31442326-11	2020	The results indicate that Lf has a neuroprotective effect on MPTP-induced PD model mice, and its mechanism may be related to anti-iron dysregulation, anti-oxidative stress, and anti-apoptosis, with apo-Lf showing greater efficacy.	Iron	130-134	lactotransferrin	Mus musculus	26-28
31912279-5	2020	At a molecular level, alpha-synuclein regulates dopamine and iron transport with PD-associated mutations in this protein causing functional disruption to these processes.	Iron	61-65	synuclein alpha	Homo sapiens	22-37
31799578-11	2020	Reduced Sod2 activity, predicted to cause superoxide-dependent iron-sulphur cluster damage, resulted in cellular iron misregulation.	Iron	63-67	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	8-12
31554933-3	2020	The iron-regulatory hormone hepcidin assures maintenance of adequate systemic iron levels and is regulated by circulating and stored iron levels, inflammation and erythropoiesis.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
31554933-3	2020	The iron-regulatory hormone hepcidin assures maintenance of adequate systemic iron levels and is regulated by circulating and stored iron levels, inflammation and erythropoiesis.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	28-36
31554933-3	2020	The iron-regulatory hormone hepcidin assures maintenance of adequate systemic iron levels and is regulated by circulating and stored iron levels, inflammation and erythropoiesis.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	28-36
32110195-13	2020	Conclusions: In this explorative study on the use of different parameters of iron metabolism for diagnosing AI during an ICU stay, low levels of commonly measured markers such as plasma iron, transferrin, and transferrin saturation have the highest sensitivity and specificity and outperform ferritin and hepcidin.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	305-313
32068375-6	2020	First, we developed a method to quantify iron levels in the liver and plasma using 2-nitroso-5-[N-n-propyl-N-(3-sulfopropyl) amino] phenol (Nitroso-PSAP).	Iron	41-45	prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) L homeolog	Xenopus laevis	148-152
31964335-17	2020	Women with iron deficiency were prescribed higher daily iron supplementation than recommended, according to new evidence, suggesting a maximal daily dose of 50 mg of elementary iron in a context of Hepcidin up-regulation in the case of an iron overload.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	198-206
31964335-17	2020	Women with iron deficiency were prescribed higher daily iron supplementation than recommended, according to new evidence, suggesting a maximal daily dose of 50 mg of elementary iron in a context of Hepcidin up-regulation in the case of an iron overload.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	198-206
31964335-17	2020	Women with iron deficiency were prescribed higher daily iron supplementation than recommended, according to new evidence, suggesting a maximal daily dose of 50 mg of elementary iron in a context of Hepcidin up-regulation in the case of an iron overload.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	198-206
31775001-5	2020	The Fe/LiF/Li2O nanocomposite released a high Li-ion capacity of 550 mA h/g based on a multi-electron inverse conversion reaction during the first-cycle charge process and exhibited better ambient stability than the counterpart with a pure Li2O matrix, and also a lower lithium-extraction voltage and faster reaction kinetics than the counterpart with a pure LiF matrix.	Iron	4-6	LIF interleukin 6 family cytokine	Homo sapiens	7-10
31775001-5	2020	The Fe/LiF/Li2O nanocomposite released a high Li-ion capacity of 550 mA h/g based on a multi-electron inverse conversion reaction during the first-cycle charge process and exhibited better ambient stability than the counterpart with a pure Li2O matrix, and also a lower lithium-extraction voltage and faster reaction kinetics than the counterpart with a pure LiF matrix.	Iron	4-6	LIF interleukin 6 family cytokine	Homo sapiens	359-362
31775001-9	2020	The high "donor" Li-ion capacity, good ambient stability, and its compatibility with existing cathode materials and battery fabrication processes make the Fe/LiF/Li2O nanocomposite a promising cathode prelithiation additive to offset the initial lithium loss and improve the energy density of LIBs.	Iron	155-157	LIF interleukin 6 family cytokine	Homo sapiens	158-161
31740582-5	2020	Ferroptosis has also been previously shown to induce cardiomyopathy, and here we observed that Bach1-/- mice are more resistant to myocardial infarction than wild-type mice and that the severity of ischemic injury is decreased by the iron-chelator deferasirox, which suppressed ferroptosis.	Iron	234-238	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	95-100
31740582-6	2020	Our findings suggest that ferroptosis is regulated at the transcriptional level by BACH1, represses genes that combat labile iron-induced oxidative stress, and is stimulated by BACH1 upon disruption of the balance between the transcriptional induction of protective genes and accumulation of iron-mediated damage.	Iron	292-296	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	177-182
31600168-4	2020	The key iron regulatory hormone hepcidin was originally identified as a cationic antimicrobial peptide (AMP), but its putative expression and role in the skin, a major site of AMP production, have never been investigated.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	32-40
32990625-2	2020	However, the influence of the hormone hepcidin on iron status has not been investigated.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	38-46
32990625-8	2020	Hepcidin levels were higher in those who were iron sufficient (Serum ferritin >=30 mug L-1) (6.62 nM vs 1.17 nM, p<0.001).	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
31811823-3	2020	Recently we reported that non-pigmented ciliary epithelial cells express ferroportin (Fpn) (Ashok, 2018), an iron export protein modulated by hepcidin, the master regulator of iron homeostasis secreted mainly by the liver.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	142-150
31585922-3	2020	Some viruses selectively infect iron - acquiring cells or influence the cellular iron metabolism via Human hemochromatosis protein (HFE) or hepcidin.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	140-148
31448845-5	2020	Although a single recessive variant in CRAT has been recently associated with neurodegeneration with brain iron accumulation, our study reports the first kinetic analysis of naturally occurring CRAT variants and demonstrates the genetic basis of carnitine acetyltransferase deficiency in a case of mitochondrial encephalopathy.	Iron	107-111	carnitine O-acetyltransferase	Homo sapiens	39-43
31448845-5	2020	Although a single recessive variant in CRAT has been recently associated with neurodegeneration with brain iron accumulation, our study reports the first kinetic analysis of naturally occurring CRAT variants and demonstrates the genetic basis of carnitine acetyltransferase deficiency in a case of mitochondrial encephalopathy.	Iron	107-111	carnitine O-acetyltransferase	Homo sapiens	194-198
33104030-13	2020	The association of elevated CSF iron and copper with tau could represent findings of increased neurodegeneration in these patients.	Iron	32-36	microtubule associated protein tau	Homo sapiens	53-56
33185611-2	2020	Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state.	Iron	27-31	ceruloplasmin	Homo sapiens	177-190
33185611-2	2020	Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state.	Iron	27-31	ceruloplasmin	Homo sapiens	192-194
33185611-2	2020	Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state.	Iron	33-35	ceruloplasmin	Homo sapiens	177-190
33185611-2	2020	Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state.	Iron	33-35	ceruloplasmin	Homo sapiens	192-194
32538848-1	2020	BACKGROUND/OBJECTIVE: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	22-30
32538848-1	2020	BACKGROUND/OBJECTIVE: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	22-30
32538848-1	2020	BACKGROUND/OBJECTIVE: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	22-30
32538848-1	2020	BACKGROUND/OBJECTIVE: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	22-30
32943150-3	2020	Herein, we report protocols for the generation and reconstitution in vitro and in vivo of myoglobin-based artificial carbene transferases incorporating non-native iron-porphynoid cofactors, also in combination with unnatural amino acids as the proximal ligand.	Iron	163-167	myoglobin	Homo sapiens	90-99
31677552-6	2020	Exposure of worms to O2 starvation conditions (i.e. hypoxia) induces a major upregulation in levels of the conserved iron-cage protein ferritin 1 (ftn-1) in the intestine, while exposure to 21% O2 decreases ftn-1 level.	Iron	117-121	Ferritin	Caenorhabditis elegans	135-145
31677552-6	2020	Exposure of worms to O2 starvation conditions (i.e. hypoxia) induces a major upregulation in levels of the conserved iron-cage protein ferritin 1 (ftn-1) in the intestine, while exposure to 21% O2 decreases ftn-1 level.	Iron	117-121	Ferritin	Caenorhabditis elegans	147-152
31677552-6	2020	Exposure of worms to O2 starvation conditions (i.e. hypoxia) induces a major upregulation in levels of the conserved iron-cage protein ferritin 1 (ftn-1) in the intestine, while exposure to 21% O2 decreases ftn-1 level.	Iron	117-121	Ferritin	Caenorhabditis elegans	207-212
31926626-6	2020	Microarrays, bioinformatic analysis, and luciferase reporter assay revealed that upregulation of miR-30b-5p in PE models plays a pivotal role in ferroptosis, by downregulating Cys2/glutamate antiporter and PAX3 and decreasing ferroportin 1 (an iron exporter) expression, resulting in decreased GSH and increased labile Fe2+.	Iron	244-248	microRNA 30b	Rattus norvegicus	97-104
31926626-6	2020	Microarrays, bioinformatic analysis, and luciferase reporter assay revealed that upregulation of miR-30b-5p in PE models plays a pivotal role in ferroptosis, by downregulating Cys2/glutamate antiporter and PAX3 and decreasing ferroportin 1 (an iron exporter) expression, resulting in decreased GSH and increased labile Fe2+.	Iron	319-323	microRNA 30b	Rattus norvegicus	97-104
31706564-2	2020	However, the relation among iron and oxygen in this population is far from understood as hepcidin is generally upregulated, potentially avoiding iron availability and harm in the context of excess oxidative stress.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	89-97
31706564-2	2020	However, the relation among iron and oxygen in this population is far from understood as hepcidin is generally upregulated, potentially avoiding iron availability and harm in the context of excess oxidative stress.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	89-97
33162505-6	2020	Moreover, IL-6 upregulates the production of hepcidin, the master regulator of systemic iron metabolism, in the liver.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	45-53
33162505-7	2020	Hepcidin reduces the iron available for erythropoiesis by downregulating the rate of iron release from macrophages.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	0-8
33162505-7	2020	Hepcidin reduces the iron available for erythropoiesis by downregulating the rate of iron release from macrophages.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	0-8
31793598-0	2019	Correction: Compliments of confinements: substitution and dimension induced magnetic origin and band-bending mediated photocatalytic enhancements in Bi1-xDyxFeO3 particulate and fiber nanostructures.	Iron	157-161	transmembrane BAX inhibitor motif containing 6	Homo sapiens	149-152
31793598-1	2019	Correction for "Compliments of confinements: substitution and dimension induced magnetic origin and band-bending mediated photocatalytic enhancements in Bi1-xDyxFeO3 particulate and fiber nanostructures" by M. Sakar et al., Nanoscale, 2015, 7, 10667-10679.	Iron	161-165	transmembrane BAX inhibitor motif containing 6	Homo sapiens	153-156
31908494-3	2019	In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.	Iron	288-292	solute carrier family 7 member 11	Homo sapiens	175-182
31852911-0	2019	Identification of The Canidae Iron Regulatory Hormone Hepcidin.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	54-62
31852911-1	2019	Hepcidins are an evolutionarily conserved class of liver-expressed peptide, from which the twenty-five amino acid hormone, hepcidin-25 (herein hepcidin), has gained significant notoriety as the master regulator of iron homeostasis in mammals.	Iron	214-218	hepcidin antimicrobial peptide	Canis lupus familiaris	123-131
31852911-1	2019	Hepcidins are an evolutionarily conserved class of liver-expressed peptide, from which the twenty-five amino acid hormone, hepcidin-25 (herein hepcidin), has gained significant notoriety as the master regulator of iron homeostasis in mammals.	Iron	214-218	hepcidin antimicrobial peptide	Homo sapiens	143-151
31852911-2	2019	Hepcidin maintains iron homeostasis by controlling the dietary absorption of iron and the mechanisms of recycling cellular iron stores.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	0-8
31852911-2	2019	Hepcidin maintains iron homeostasis by controlling the dietary absorption of iron and the mechanisms of recycling cellular iron stores.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
31852911-2	2019	Hepcidin maintains iron homeostasis by controlling the dietary absorption of iron and the mechanisms of recycling cellular iron stores.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
31852911-6	2019	Importantly, in the greyhound, the measured hepcidin peptide showed a similar temporal pattern to total serum iron, consistent with our understanding of hepcidin regulating iron homeostasis, in agreement with human diagnostics, and providing added translational evidence of the measured peptide being the iron regulatory hormone of the Canidae.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	44-52
31852911-6	2019	Importantly, in the greyhound, the measured hepcidin peptide showed a similar temporal pattern to total serum iron, consistent with our understanding of hepcidin regulating iron homeostasis, in agreement with human diagnostics, and providing added translational evidence of the measured peptide being the iron regulatory hormone of the Canidae.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	153-161
31852911-6	2019	Importantly, in the greyhound, the measured hepcidin peptide showed a similar temporal pattern to total serum iron, consistent with our understanding of hepcidin regulating iron homeostasis, in agreement with human diagnostics, and providing added translational evidence of the measured peptide being the iron regulatory hormone of the Canidae.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	44-52
31852911-6	2019	Importantly, in the greyhound, the measured hepcidin peptide showed a similar temporal pattern to total serum iron, consistent with our understanding of hepcidin regulating iron homeostasis, in agreement with human diagnostics, and providing added translational evidence of the measured peptide being the iron regulatory hormone of the Canidae.	Iron	173-177	hepcidin antimicrobial peptide	Homo sapiens	153-161
31847364-1	2019	Lactoferrin (Lf) is an iron-binding glycoprotein protein known to have immune-modulatory role and recently, its anticancerous effect against different cancer cell types was emphasized.	Iron	23-27	lactotransferrin	Bos taurus	0-11
31831856-0	2019	Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery.	Iron	78-82	iron-sulfur cluster assembly 2	Homo sapiens	34-39
31701665-0	2019	ROS-Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide-Containing Recombinant Apoferritin.	Iron	82-88	ferritin heavy chain 1	Homo sapiens	144-155
31701665-3	2019	To overcome this problem, a recombinant apoferritin nanocarrier containing ferriferous oxide (M-HFn) is constructed to produce auxiliary exogenous Fe(II) when delivering AS to cancer cells.	Iron	147-153	ferritin heavy chain 1	Homo sapiens	40-51
31557572-5	2019	The results showed that split iron supplementation efficiently improved hematological status of piglets and attenuated the induction of hepcidin expression, which resulted in the recovery of piglets from iron deficiency and the increase of iron utilization.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	136-144
31557572-5	2019	The results showed that split iron supplementation efficiently improved hematological status of piglets and attenuated the induction of hepcidin expression, which resulted in the recovery of piglets from iron deficiency and the increase of iron utilization.	Iron	204-208	hepcidin antimicrobial peptide	Homo sapiens	136-144
31690120-1	2019	Ferroportin 1 (FPN1) is a major facilitator superfamily transporter that is essential for proper maintenance of human iron homeostasis at the systemic and cellular level.	Iron	118-122	solute carrier family 40 member 1	Homo sapiens	0-13
31690120-1	2019	Ferroportin 1 (FPN1) is a major facilitator superfamily transporter that is essential for proper maintenance of human iron homeostasis at the systemic and cellular level.	Iron	118-122	solute carrier family 40 member 1	Homo sapiens	15-19
31690120-2	2019	FPN1 dysfunction leads to the progressive accumulation of iron in reticuloendothelial cells, causing hemochromatosis type 4A (or ferroportin disease), an autosomal dominant disorder that displays large phenotypic heterogeneity.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	0-4
31127639-0	2019	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	Iron	68-72	SMAD family member 1	Mus musculus	23-28
31127639-0	2019	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	Iron	68-72	SMAD family member 9	Mus musculus	41-46
31127639-2	2019	SMAD1/5 transcription factors, activated by bone morphogenetic protein (BMP) signaling, are major regulators of hepcidin production in response to iron; however, the role of SMAD8 and the contribution of SMADs to hepcidin production by other systemic cues remain uncertain.	Iron	147-151	SMAD family member 1	Mus musculus	0-7
31127639-11	2019	These mice reveal the redundant but critical role of SMAD8 in hepcidin and iron homeostasis regulation, establish a requirement for SMAD1/5/8 in hepcidin regulation by testosterone and EGF but not inflammation, and suggest a pathogenic role for both iron loading and SMAD1/5/8 deficiency in liver injury and fibrosis.	Iron	75-79	SMAD family member 9	Mus musculus	53-58
31106422-3	2019	Iron enters the cardiomyocyte through the classic pathway, by binding to the transferrin 1 receptor (TfR1), but also through other routes: T-type calcium channel (TTCC), divalent metal transporter 1 (DMT1), L-type calcium channel (LTCC), Zrt-, Irt-like Proteins (ZIP) 8 and 14.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	170-198
31106422-3	2019	Iron enters the cardiomyocyte through the classic pathway, by binding to the transferrin 1 receptor (TfR1), but also through other routes: T-type calcium channel (TTCC), divalent metal transporter 1 (DMT1), L-type calcium channel (LTCC), Zrt-, Irt-like Proteins (ZIP) 8 and 14.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	200-204
31514091-9	2019	Hence, the simultaneous determination of Cp, hTf, alpha2M and the Hp-Hb complex in plasma in <25min has the potential to provide new insight into disease processes associated with the bioinorganic chemistry of Cu, Fe and Zn.	Iron	214-216	alpha-2-macroglobulin	Homo sapiens	50-57
31373375-10	2019	RESULTS: In the hippocampus, APP/PS1-High Fe mice had significantly higher iron concentration (2.5-fold) and ferritin (2.0-fold) than APP/PS1-Ctrl mice (P < 0.001), and WT-High Fe mice had significantly higher ferritin (2.0-fold) than WT-Ctrl mice (P < 0.001).	Iron	177-179	presenilin 1	Mus musculus	33-36
31373375-11	2019	Interestingly, APP/PS1 mice had significantly higher iron concentration (2-3-fold) and ferritin (2-2.5-fold) than WT mice fed either diet (P < 0.001).	Iron	53-57	presenilin 1	Mus musculus	19-22
31373375-12	2019	Histological analysis indicated that iron accumulated in the hippocampal dentate gyrus region in APP/PS1 mice, consistent with the pattern of Abeta deposition.	Iron	37-41	presenilin 1	Mus musculus	101-104
31373375-12	2019	Histological analysis indicated that iron accumulated in the hippocampal dentate gyrus region in APP/PS1 mice, consistent with the pattern of Abeta deposition.	Iron	37-41	amyloid beta (A4) precursor protein	Mus musculus	142-147
31373375-13	2019	For both mouse strains, iron treatment induced Abeta and phospho-tau expression (1.5-3-fold) in the hippocampus, but had little impact on oxidative stress and cognitive function.	Iron	24-28	amyloid beta (A4) precursor protein	Mus musculus	47-52
31373375-15	2019	CONCLUSIONS: Dietary iron overload induces iron disorder and Abeta and phospho-tau expression in the hippocampus of adult WT and APP/PS1 transgenic mice.	Iron	21-25	amyloid beta (A4) precursor protein	Mus musculus	61-66
31373375-15	2019	CONCLUSIONS: Dietary iron overload induces iron disorder and Abeta and phospho-tau expression in the hippocampus of adult WT and APP/PS1 transgenic mice.	Iron	21-25	presenilin 1	Mus musculus	133-136
31563540-1	2019	Hepcidin is a peptide hormone regulating iron metabolism, the dyshomeostasis of which has been implicated in dementia.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
31775259-1	2019	The interaction between hepcidin and ferroportin is the key mechanism involved in regulation of systemic iron homeostasis.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	24-32
31753999-4	2019	SLC11A1 modestly diminished iron availability and acutely restricted Salmonella access to magnesium.	Iron	28-32	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-7
31738431-9	2019	Interestingly, Fe starvation leads to a significant temporal increase of glutathione S-transferase at both the transcriptional level and enzymatic activity level, which indicates the involvement of glutathione in response to Fe stress in wheat roots.	Iron	15-17	glutathione S-transferase	Triticum aestivum	73-98
31738431-9	2019	Interestingly, Fe starvation leads to a significant temporal increase of glutathione S-transferase at both the transcriptional level and enzymatic activity level, which indicates the involvement of glutathione in response to Fe stress in wheat roots.	Iron	225-227	glutathione S-transferase	Triticum aestivum	73-98
31625542-4	2019	Due to the small limiting potential of -0.78 V and the activation barrier (1.56 eV), FeN3-gra exhibits the highest catalytic activity towards CO2 reduction.	Iron	85-89	complement C2	Homo sapiens	142-145
31814801-2	2019	Hepcidin as a key regulator of iron metabolism is pivotal in mediating the occurrence of anemia of chronic disease.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
31814801-5	2019	Importantly, we found that the increased levels of serum hepcidin were positively correlated with the severity of anemia and the imbalance of iron metabolism in anemic UC and CD patients.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	57-65
31651000-1	2019	A bisphosphide-bridged diiron hexacarbonyl complex 3 with NEt2 groups on the phosphide bridge was synthesized to examine a new proton relay system from the NEt2 group to the bridging hydride between the two iron centers.	Iron	25-29	tetraspanin 12	Homo sapiens	58-62
31651000-1	2019	A bisphosphide-bridged diiron hexacarbonyl complex 3 with NEt2 groups on the phosphide bridge was synthesized to examine a new proton relay system from the NEt2 group to the bridging hydride between the two iron centers.	Iron	25-29	tetraspanin 12	Homo sapiens	156-160
31651000-4	2019	The molecular structure of 3 indicated that the trigonal plane of the NEt2 group was forced to face the Fe-Fe bond to avoid steric congestion with the naphthylene group linking the two phosphide groups.	Iron	104-106	tetraspanin 12	Homo sapiens	70-74
31651000-4	2019	The molecular structure of 3 indicated that the trigonal plane of the NEt2 group was forced to face the Fe-Fe bond to avoid steric congestion with the naphthylene group linking the two phosphide groups.	Iron	107-109	tetraspanin 12	Homo sapiens	70-74
31719592-5	2019	We investigated hepcidin-mediated redistribution of iron in the immediate post-natal period and tested the effect of the observed hypoferremia on the growth of pathogens frequently associated with neonatal sepsis.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	16-24
31719592-10	2019	These levels remained suppressed to 48 h of age with some recovery by 96 h. Reductions in serum iron were associated with high hepcidin and IL-6 levels.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	127-135
31717495-1	2019	Hepcidin is a liver-derived peptide hormone that is related to iron balance and immunity in humans.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
31699745-1	2019	INTRODUCTION: Hepcidin production is normally upregulated by iron stores, and in obesity has been shown to be overexpressed and correlated with low iron status.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	14-22
31699745-1	2019	INTRODUCTION: Hepcidin production is normally upregulated by iron stores, and in obesity has been shown to be overexpressed and correlated with low iron status.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	14-22
31699745-2	2019	The increased hepcidin may restrain the iron release from the cells by affecting the expression of ferroportin, which probably associates with the development of diabetes complication.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	14-22
31524964-0	2019	Alcohol"s dysregulation of maternal-fetal IL-6 and p-STAT3 is a function of maternal iron status.	Iron	85-89	signal transducer and activator of transcription 3	Rattus norvegicus	53-58
31524964-4	2019	Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3.	Iron	26-30	erythropoietin	Rattus norvegicus	120-123
31524964-4	2019	Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3.	Iron	26-30	signal transducer and activator of transcription 3	Rattus norvegicus	148-153
31338833-7	2019	The prognoses of patients with TRNT1 and SLC2A38 mutations were generally dismal because of comorbidities or severe iron overload.	Iron	116-120	tRNA nucleotidyl transferase 1	Homo sapiens	31-36
31228832-0	2019	NO oxidation over Fe-based catalysts supported on montmorillonite K10, gamma-alumina and ZSM-5 with gas-phase H2O2.	Iron	18-20	keratin 10	Homo sapiens	66-69
31228832-1	2019	The catalytic gas-phase H2O2 oxidation of NO was achieved over Fe-based catalysts supported on montmorillonite K10, gamma-alumina and ZSM-5.	Iron	63-65	keratin 10	Homo sapiens	111-114
31228832-2	2019	ESR tests illustrate that the three catalysts can catalyze decomposition of H2O2 yielding highly reactive hydroxyl radicals, of which Fe/K10 has the fastest rate, followed by Fe/gamma-alumina.	Iron	134-136	keratin 10	Homo sapiens	137-140
31228832-3	2019	Fe3+ in Fe/K10 and Fe/gamma-alumina show lower density of electron cloud due to a strong interaction between Fe3+ and the support, which benefits the electron transfer from the H2O2 to Fe3+, thus favoring the production of hydroxyl radicals.	Iron	0-2	keratin 10	Homo sapiens	11-14
31228832-4	2019	Fe species exist on the surface of Fe/K10 mainly in the form of Fe2O3, whereas Fe species of Fe/gamma-alumina and Fe/ZSM-5 exist mainly in the form of Fe3O4, and it is found that Fe2O3 is more active than Fe3O4 in catalytic gas-phase H2O2 oxidation of NO.	Iron	0-2	keratin 10	Homo sapiens	38-41
31228832-5	2019	Interestingly, Fe/ZSM-5 has the lowest efficiency in generating hydroxyl radicals, its NO removal efficiency is 90%, which is much higher than 47.5% for Fe/gamma-alumina and 62.3% for Fe/K10.	Iron	15-17	keratin 10	Homo sapiens	187-190
29911470-4	2019	Using induced pluripotent stem cell (iPSC)-derived brain endothelial cells (huECs) as a human BBB model, we demonstrate the ability of transferrin, hepcidin, and DMT1 to impact iron transport and release.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	148-156
29911470-4	2019	Using induced pluripotent stem cell (iPSC)-derived brain endothelial cells (huECs) as a human BBB model, we demonstrate the ability of transferrin, hepcidin, and DMT1 to impact iron transport and release.	Iron	177-181	doublesex and mab-3 related transcription factor 1	Homo sapiens	162-166
31499193-5	2019	Also, it disturbed the iron homeostasis through increasing C/EBP homologous protein (CHOP), decreasing phosphorylated cAMP responsive element binding protein(P-CREB) and hepcidin levels leading to significant serum and hepatic iron overload.	Iron	23-27	DNA-damage inducible transcript 3	Rattus norvegicus	85-89
31592630-3	2019	To address this issue, herein, we report a class of IrM (M = Ni, Co, Fe) catalysts with diluted Ir content fabricated via a eutectic-directed self-templating strategy.	Iron	69-71	maternally expressed 8, small nucleolar RNA host gene	Homo sapiens	52-55
31243222-1	2019	Objective Hepcidin is a master iron regulator hormone produced by the liver, but precise mechanism underlying its involvement in iron overload in hepatitis C virus (HCV) infection remains unclear.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	10-18
31243222-2	2019	We investigated the serum hepcidin levels against iron overload before and after HCV eradication.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	26-34
31243222-4	2019	We also assessed the serum erythroferrone (ERFE) levels to investigate its association with iron metabolism changes.	Iron	92-96	erythroferrone	Homo sapiens	43-47
31243222-13	2019	These results indicate the improvement of inadequate hepcidin secretion against iron overload after HCV eradication.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	53-61
31243222-14	2019	Downregulation of ERFE may have affected the improvement of iron metabolism.	Iron	60-64	erythroferrone	Homo sapiens	18-22
31775479-4	2019	The relationship between serum hepcidin concentration and erythropoiesis and iron homeostasis parameters was evaluated.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	31-39
31775479-10	2019	Conclusion: The decreased serum hepcidin level in patients with classical PNH was mainly influenced by iron metabolism factors.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	32-40
31614529-6	2019	Inflammation is also inhibitory to erythropoietin function and may directly increase hepcidin level, which influences iron metabolism.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	85-93
31441223-4	2019	Mechanistically, we show that iron overload leads to a decrease in Akt-mediated repression of tuberous sclerosis complex (TSC2) and Rheb-mediated mTORC1 activation on autolysosomes, thereby inhibiting autophagic-lysosome regeneration.	Iron	30-34	TSC complex subunit 2	Mus musculus	122-126
31441223-5	2019	Constitutive activation of mTORC1 or iron withdrawal replenishes lysosomal pools via increased mTORC1-UVRAG signaling, which restores insulin sensitivity.	Iron	37-41	UV radiation resistance associated gene	Mus musculus	102-107
31441223-6	2019	Induction of iron overload via intravenous iron-dextran delivery in mice also results in insulin resistance accompanied by abnormal autophagosome accumulation, lysosomal loss, and decreased mTORC1-UVRAG signaling in muscle.	Iron	13-17	UV radiation resistance associated gene	Mus musculus	197-202
31441223-7	2019	Collectively, our results show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.	Iron	44-48	UV radiation resistance associated gene	Mus musculus	110-115
31582748-0	2019	Unraveling the coordination structure-performance relationship in Pt1/Fe2O3 single-atom catalyst.	Iron	70-75	zinc finger protein 77	Homo sapiens	66-69
31486956-2	2019	Four different forms of the disease have each been attributed to point mutations in proteins involved in iron-sulfur (Fe-S) biosynthesis; in particular, MMDS2 has been associated with the protein BOLA3.	Iron	118-122	bolA family member 3	Homo sapiens	153-158
31486956-2	2019	Four different forms of the disease have each been attributed to point mutations in proteins involved in iron-sulfur (Fe-S) biosynthesis; in particular, MMDS2 has been associated with the protein BOLA3.	Iron	118-122	bolA family member 3	Homo sapiens	196-201
31486956-5	2019	Herein we describe procedures to isolate and characterize the human holo BOLA3 protein in terms of Fe-S cluster binding and trafficking and demonstrate that human BOLA3 can form a functional homodimer capable of engaging in Fe-S cluster transfer.	Iron	99-103	bolA family member 3	Homo sapiens	73-78
31486956-5	2019	Herein we describe procedures to isolate and characterize the human holo BOLA3 protein in terms of Fe-S cluster binding and trafficking and demonstrate that human BOLA3 can form a functional homodimer capable of engaging in Fe-S cluster transfer.	Iron	224-228	bolA family member 3	Homo sapiens	73-78
31486956-5	2019	Herein we describe procedures to isolate and characterize the human holo BOLA3 protein in terms of Fe-S cluster binding and trafficking and demonstrate that human BOLA3 can form a functional homodimer capable of engaging in Fe-S cluster transfer.	Iron	224-228	bolA family member 3	Homo sapiens	163-168
31400894-3	2019	Our laboratory previously conducted a randomized clinical trial investigating the effectiveness of lactoferrin, an iron-binding protein found in colostrum, as a treatment for calf diarrhea.	Iron	115-119	lactotransferrin	Bos taurus	99-110
31437721-5	2019	Within neuritic plaques, dystrophic hyperphosphorylated tau-positive neurites appear as clusters of punctate, bulbous, and thread-like structures focused around capillaries and colocalize with iron deposits characteristic of microhemorrhage.	Iron	193-197	microtubule associated protein tau	Homo sapiens	56-59
31527235-1	2019	MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis.	Iron	92-96	CDGSH iron sulfur domain 1	Homo sapiens	0-8
31527235-8	2019	Addition of the VDAC inhibitor 4,4"-diisothiocyanatostilbene-2,2"-disulfonate (DIDS) prevents both mitoNEET binding in vitro and mitoNEET-dependent mitochondrial iron accumulation in situ.	Iron	162-166	CDGSH iron sulfur domain 1	Homo sapiens	129-137
31569434-7	2019	Endosomes with low pH can dissolve iron from AuFe NPs, and thus, the intracellularly released iron ions up-regulate the hypoxia-inducible factor 1alpha and vascular endothelial growth factor (VEGF) expression.	Iron	35-39	hypoxia inducible factor 1, alpha subunit	Mus musculus	120-151
31569434-7	2019	Endosomes with low pH can dissolve iron from AuFe NPs, and thus, the intracellularly released iron ions up-regulate the hypoxia-inducible factor 1alpha and vascular endothelial growth factor (VEGF) expression.	Iron	94-98	hypoxia inducible factor 1, alpha subunit	Mus musculus	120-151
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Iron	229-233	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	63-101
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Iron	229-233	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	103-108
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Iron	246-250	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	63-101
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Iron	246-250	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	103-108
31480699-9	2019	The iron chelating property of didox may contribute to its antitumor activity not only blocking the formation of the tyrosil radical on Tyr122 (such as HU) on RRM2 (essential for its activity) but also sequestering the iron needed by this enzyme and to the cell proliferation.	Iron	4-8	ribonucleotide reductase regulatory subunit M2	Homo sapiens	159-163
31480699-9	2019	The iron chelating property of didox may contribute to its antitumor activity not only blocking the formation of the tyrosil radical on Tyr122 (such as HU) on RRM2 (essential for its activity) but also sequestering the iron needed by this enzyme and to the cell proliferation.	Iron	219-223	ribonucleotide reductase regulatory subunit M2	Homo sapiens	159-163
30661261-0	2019	Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.	Iron	0-4	presenilin 1	Mus musculus	125-128
31252187-1	2019	OBJECTIVES: A major regulatory peptide in iron metabolism, hepcidin, has been shown to predict mortality in HIV-infected tuberculosis patients.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	59-67
31273911-8	2019	However, the process of HO-1 metabolism can be toxic owing to iron overload and the activation of succedent pathways, for example, the Fenton reaction and oxidative damage; the overall effect of HO-1 in SAH and ICH tends to be protective and harmful, respectively, given the different pathophysiological changes in these two types of haemorrhagic stroke.	Iron	62-66	heme oxygenase 1	Homo sapiens	24-28
31226389-0	2019	Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	64-72
31345363-5	2019	The aims of this study were to investigate the status of NOX1, NOX4 and NOX5 and its relationship with serum iron metabolism biomarkers in relapsing-remitting MS patients.	Iron	109-113	NADPH oxidase 5	Homo sapiens	72-76
31308252-7	2019	SPEA provides the ability to study numerous important hormones in a single rapid assay, which we applied to study the intermittent fasting response and observed several unexpected changes including decreased plasma abundance of the iron homeostasis regulator hepcidin.	Iron	232-236	hepcidin antimicrobial peptide	Homo sapiens	259-267
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	85-87	glutaredoxin 3	Homo sapiens	188-193
30888116-4	2019	The lipid hydroperoxidase glutathione peroxidase 4 (GPX4) converts lipid hydroperoxides to lipid alcohols, and this process prevents the iron (Fe2+ )-dependent formation of toxic lipid reactive oxygen species (ROS).	Iron	137-141	glutathione peroxidase 4	Homo sapiens	26-50
30888116-4	2019	The lipid hydroperoxidase glutathione peroxidase 4 (GPX4) converts lipid hydroperoxides to lipid alcohols, and this process prevents the iron (Fe2+ )-dependent formation of toxic lipid reactive oxygen species (ROS).	Iron	137-141	glutathione peroxidase 4	Homo sapiens	52-56
30888116-5	2019	Inhibition of GPX4 function leads to lipid peroxidation and can result in the induction of ferroptosis, an iron-dependent, non-apoptotic form of cell death.	Iron	107-111	glutathione peroxidase 4	Homo sapiens	14-18
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	102-106	sterol regulatory element binding transcription factor 1	Mus musculus	210-220
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	144-148	sterol regulatory element binding transcription factor 1	Mus musculus	210-220
31270208-7	2019	Consistent with the known effects of Hamp up-regulation, SREBP-1a-overexpressing mice displayed signs of dysregulation in iron metabolism, including reduced serum iron and increased hepatic and splenic iron storage.	Iron	122-126	sterol regulatory element binding transcription factor 1	Mus musculus	57-65
31270208-7	2019	Consistent with the known effects of Hamp up-regulation, SREBP-1a-overexpressing mice displayed signs of dysregulation in iron metabolism, including reduced serum iron and increased hepatic and splenic iron storage.	Iron	163-167	sterol regulatory element binding transcription factor 1	Mus musculus	57-65
31270208-7	2019	Consistent with the known effects of Hamp up-regulation, SREBP-1a-overexpressing mice displayed signs of dysregulation in iron metabolism, including reduced serum iron and increased hepatic and splenic iron storage.	Iron	163-167	sterol regulatory element binding transcription factor 1	Mus musculus	57-65
31270208-8	2019	Conversely, liver-specific depletion of the nuclear forms of SREBPs, as in SREBP cleavage-activating protein knockout mice, impaired lipopolysaccharide-induced up-regulation of hepatic Hamp Together, these results indicate that the SREBP-1a/c transcription regulators activate hepcidin expression and thereby contribute to the control of mammalian iron metabolism.	Iron	348-352	sterol regulatory element binding transcription factor 1	Mus musculus	232-240
31423425-1	2019	Hepcidin is the hyposideremic hormone regulating iron metabolism.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
31423425-3	2019	The main site of hepcidin production is the liver where its synthesis is modulated by iron, inflammation and erythropoietic signaling.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	17-25
31423425-4	2019	However, hepcidin locally produced in several peripheral organs seems to be an important actor for the maintenance of iron homeostasis in these organs.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	9-17
31387234-8	2019	Among the numerous proteins involved in iron metabolism, hepcidin is a liver-derived peptide hormone, which is the master regulator of iron metabolism.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	57-65
31387234-8	2019	Among the numerous proteins involved in iron metabolism, hepcidin is a liver-derived peptide hormone, which is the master regulator of iron metabolism.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	57-65
31387234-10	2019	Hepcidin synthesis is controlled by several factors such as iron levels, anaemia, infection, inflammation, and erythropoietic activity.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
31101625-10	2019	Key molecules involved in iron recycling were also highly expressed in BM F4/80+Epor-eGFP+ macrophages, suggesting that EBI macrophages may provide an iron source for erythropoiesis within this niche.	Iron	26-30	erythropoietin receptor	Homo sapiens	80-84
30776900-0	2019	Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	91-95
30776900-3	2019	In this study, we found a profound increase of amyloid formation with increasing FeCl3 treatment, and a distinct change in APP metabolism and expression of iron homeostasis proteins (ferritin, Fpn1, iron regulatory protein) was observed at the 300 uM concentration of FeCl3.	Iron	156-160	solute carrier family 40 member 1	Homo sapiens	193-197
30776900-4	2019	Further results revealed that extracellular iron accumulation might potentially induce binding of APP to BACE1 for amyloid formation and decrease the capability of APP/Fpn1 in mediating iron export.	Iron	44-48	solute carrier family 40 member 1	Homo sapiens	168-172
30776900-4	2019	Further results revealed that extracellular iron accumulation might potentially induce binding of APP to BACE1 for amyloid formation and decrease the capability of APP/Fpn1 in mediating iron export.	Iron	186-190	solute carrier family 40 member 1	Homo sapiens	168-172
31236859-9	2019	Moreover, as  tox increases, it indicates an increase in the concentration of eleven (Ca, P, Co, Cr, Fe, I, Mn, Li, Ni, V, As) and a decrease of two elements in hair (B, Si); for six elements (K, Mg, Na, Cu, Zn, Sn), such a connection was not revealed.	Iron	101-103	thymocyte selection associated high mobility group box	Equus caballus	14-17
31152917-0	2019	A case of Woodhouse-Sakati syndrome with pituitary iron deposition, cardiac and intestinal anomalies, with a novel mutation in DCAF17.	Iron	51-55	DDB1 and CUL4 associated factor 17	Homo sapiens	127-133
31152917-3	2019	We present a new case with pituitary iron deposition, cardiac and intestinal anomalies, with a novel mutation in DCAF17 gene.	Iron	37-41	DDB1 and CUL4 associated factor 17	Homo sapiens	113-119
30733275-2	2019	Hepcidin is the major regulator of systemic iron homeostasis.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
30733275-9	2019	In cross-sectional analyses at 5 and 12 months of age, we identified expected relationships of hepcidin with iron and inflammatory markers, but also observed significant negative associations between hepcidin and antecedent weight gain.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	95-103
30733275-11	2019	Infants who grow rapidly in this setting are at particular risk of depletion of iron stores, but since hepcidin concentrations decrease with weight gain, they may also be the most responsive to oral iron interventions.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	103-111
31054513-7	2019	FE results suggested that viscoelastic relaxation of cartilage was a major contributor to the rate dependency and that tensile stresses localized at the indenter tip was a governing factor in crack nucleation.	Iron	0-2	TOR signaling pathway regulator	Homo sapiens	162-165
31054513-8	2019	SEM images combined with microindentation and FE results suggested that the solid matrix in the vicinity of the tip experienced relatively large relaxation and kinematic fiber rearrangement at the slow loading rate in comparison to the fast loading rate.	Iron	46-48	TOR signaling pathway regulator	Homo sapiens	112-115
30929276-2	2019	The IRT1 root metal transporter represents a textbook example in which detailed regulatory networks have been shown to integrate several endogenous and exogenous cues at various levels to regulate its expression and to fine tune iron uptake.	Iron	229-233	allograft inflammatory factor 1	Homo sapiens	4-8
31002437-0	2019	Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist.	Iron	122-126	interleukin 1 receptor antagonist	Homo sapiens	160-193
31171361-1	2019	The transformation of hepatic stellate cells (HSCs) to activated myofibroblasts plays a critical role in the progression of hepatic fibrosis, while iron-catalyzed production of free radical, including reaction and active oxygen (ROS), and activation and transformation of HSC into a myofibroblasts has been regarded as a major mechanism.	Iron	148-152	fucosyltransferase 1 (H blood group)	Homo sapiens	46-49
31171361-2	2019	In the present study, we attempted to investigate the mechanism of iron overload in hepatic fibrosis from the perspective of regulating HSC activation via oxidative stress and miR-374a/Myc axis.	Iron	67-71	fucosyltransferase 1 (H blood group)	Homo sapiens	136-139
31171361-2	2019	In the present study, we attempted to investigate the mechanism of iron overload in hepatic fibrosis from the perspective of regulating HSC activation via oxidative stress and miR-374a/Myc axis.	Iron	67-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	185-188
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	Iron	342-346	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-25
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	Iron	342-346	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-107
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	Iron	80-84	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-63
31357546-5	2019	The potentially toxic free heme is converted by heme oxygenases (HOs) into carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is reduced to bilirubin (BR).	Iron	97-101	chromosome 12 open reading frame 73	Homo sapiens	158-167
31357546-5	2019	The potentially toxic free heme is converted by heme oxygenases (HOs) into carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is reduced to bilirubin (BR).	Iron	97-101	chromosome 12 open reading frame 73	Homo sapiens	169-171
31229404-2	2019	Here, we describe a mechanism of FBXL5 regulation involving its interaction with the cytosolic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, FAM96B, and CIAO1.	Iron	95-99	cytosolic iron-sulfur assembly component 2B	Homo sapiens	160-166
31344980-1	2019	Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin.	Iron	100-112	heme oxygenase 1	Homo sapiens	0-16
31344980-1	2019	Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin.	Iron	100-112	heme oxygenase 1	Homo sapiens	18-22
31354776-2	2019	In Arabidopsis thaliana (Arabidopsis), the root transcriptional response to WCS417 shows significant overlap with the root response to iron (Fe) starvation, including activation of the marker genes MYB72 and IRT1.	Iron	135-139	myb domain protein 72	Arabidopsis thaliana	198-203
31354776-2	2019	In Arabidopsis thaliana (Arabidopsis), the root transcriptional response to WCS417 shows significant overlap with the root response to iron (Fe) starvation, including activation of the marker genes MYB72 and IRT1.	Iron	141-143	myb domain protein 72	Arabidopsis thaliana	198-203
31354776-9	2019	Moreover, the leaf Fe status-dependent shoot-to-root signaling mutant opt3-2, which is impaired in the phloem-specific Fe transporter OPT3, still up-regulated the Fe deficiency response genes MYB72 and IRT1 in response to WCS417.	Iron	19-21	myb domain protein 72	Arabidopsis thaliana	192-197
30991335-4	2019	Soils enriched in Al, Cr, Fe, Hf, Mo, Ni, Th, Ti, U, V and Zr (PC1) are spatially associated with mapped units of the basaltic Dunedin Volcanic Group, indicating a geogenic source.	Iron	26-28	proprotein convertase subtilisin/kexin type 1	Homo sapiens	63-66
31292266-3	2019	Body iron content, tissue distribution, and the supply of iron for erythropoiesis are controlled by the hormone hepcidin, which is regulated by erythroblasts through secretion of the erythroid hormone erythroferrone (ERFE).	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	112-120
31292266-3	2019	Body iron content, tissue distribution, and the supply of iron for erythropoiesis are controlled by the hormone hepcidin, which is regulated by erythroblasts through secretion of the erythroid hormone erythroferrone (ERFE).	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	112-120
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	6-14
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	85-89	erythroferrone	Homo sapiens	40-44
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	85-89	erythroferrone	Homo sapiens	150-154
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	184-188	hepcidin antimicrobial peptide	Homo sapiens	6-14
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	184-188	erythroferrone	Homo sapiens	40-44
31292266-7	2019	Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity.	Iron	184-188	erythroferrone	Homo sapiens	150-154
31279336-9	2019	In-Silico prediction of the ISCA2 secondary structure showed that a helix motif in the Fe-S biosynthesis domain of ISCA2 protein will be eliminated as a result of this variant.	Iron	87-91	iron-sulfur cluster assembly 2	Homo sapiens	28-33
31279336-9	2019	In-Silico prediction of the ISCA2 secondary structure showed that a helix motif in the Fe-S biosynthesis domain of ISCA2 protein will be eliminated as a result of this variant.	Iron	87-91	iron-sulfur cluster assembly 2	Homo sapiens	115-120
31005753-11	2019	We speculate that elevated hepcidin levels in obese pregnant women impede iron absorption and interfere with transplacental iron transfer.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	27-35
31005753-11	2019	We speculate that elevated hepcidin levels in obese pregnant women impede iron absorption and interfere with transplacental iron transfer.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	27-35
31353879-0	2019	Increased hepcidin expression in adipose tissue as a primary cause of obesity-related inhibition of iron absorption.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	10-18
30761635-1	2019	Lactoferrin (LF) is an Fe3+ -binding glycoprotein first recognized in milk and then in other epithelial secretions and barrier body fluids to which many different functions have been attributed to LF, including protection from iron-induced lipid peroxidation, immunomodulation, cell growth regulation, DNA and RNA binding, as well as transcriptional activation, ets.	Iron	227-231	lactotransferrin	Bos taurus	0-11
31316397-1	2019	Divalent metal transporter 1 (DMT1) is a key transporter of iron uptake and delivering in human and animals.	Iron	60-64	solute carrier family 11 member 2	Homo sapiens	0-28
31316397-1	2019	Divalent metal transporter 1 (DMT1) is a key transporter of iron uptake and delivering in human and animals.	Iron	60-64	solute carrier family 11 member 2	Homo sapiens	30-34
31152133-4	2019	The iron export protein ferroportin (FPN) and its antagonist peptide hepcidin control systemic iron levels by regulating release from the gut and spleen, the sites of absorption and recycling, respectively.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	69-77
31152133-4	2019	The iron export protein ferroportin (FPN) and its antagonist peptide hepcidin control systemic iron levels by regulating release from the gut and spleen, the sites of absorption and recycling, respectively.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	69-77
31152133-10	2019	The regulation of ET-1 by iron was also demonstrated in healthy humans exposed to hypoxia and in PASMCs from PAH patients with mutations in bone morphogenetic protein receptor type II.	Iron	26-30	bone morphogenetic protein receptor type 2	Homo sapiens	140-183
31120730-2	2019	In this study, a new organic-cadmium (Cd) complex formed through Cd2+ coordination with p-phenylenediamine (PPD) was used to synthesize highly active Fe-embedded N-doped carbon catalysts for the first time.	Iron	150-152	CD2 molecule	Homo sapiens	65-68
31011744-3	2019	The dysfunction of ATP7B/Atp7b leads to a reduction in the incorporation of copper into apoceruloplasmin; this decreases the ferroxidase activity of ceruloplasmin necessary for the efflux of iron from cells and reduces the release of copper from hepatocytes to the bile; this results in a massive hepatic copper accumulation.	Iron	191-195	ceruloplasmin	Mus musculus	125-136
31011744-3	2019	The dysfunction of ATP7B/Atp7b leads to a reduction in the incorporation of copper into apoceruloplasmin; this decreases the ferroxidase activity of ceruloplasmin necessary for the efflux of iron from cells and reduces the release of copper from hepatocytes to the bile; this results in a massive hepatic copper accumulation.	Iron	191-195	ceruloplasmin	Mus musculus	91-104
31011744-4	2019	A decrease in the ferroxidase activity of ceruloplasmin in the tx-J mice emphasises the practicality of this animal model for the exploration of disturbances in iron balance triggered by dysregulation of copper metabolism.	Iron	161-165	ceruloplasmin	Mus musculus	42-55
31011744-7	2019	Hepatic iron retention was accompanied by decreased expression of the membrane form of ceruloplasmin in both liver cell types.	Iron	8-12	ceruloplasmin	Mus musculus	87-100
31011744-9	2019	We conclude that even when the ferroportin expression is high, ceruloplasmin remains a limiting factor in the release of iron to the extracellular environment.	Iron	121-125	ceruloplasmin	Mus musculus	63-76
30997707-2	2019	Herein we report the activation of a non-heme FeIII -OOH intermediate in a synthetic monoiron system using FeIII (OTf)3 to form a high-valent oxidant capable of effecting cyclohexane and benzene hydroxylation within seconds at -40  C. Our results show that the second iron acts as a Lewis acid to activate the iron-hydroperoxo intermediate, leading to the formation of a powerful FeV =O oxidant-a possible role for the second iron in sMMO.	Iron	89-93	POU class 5 homeobox 1	Homo sapiens	114-119
30997707-2	2019	Herein we report the activation of a non-heme FeIII -OOH intermediate in a synthetic monoiron system using FeIII (OTf)3 to form a high-valent oxidant capable of effecting cyclohexane and benzene hydroxylation within seconds at -40  C. Our results show that the second iron acts as a Lewis acid to activate the iron-hydroperoxo intermediate, leading to the formation of a powerful FeV =O oxidant-a possible role for the second iron in sMMO.	Iron	268-272	POU class 5 homeobox 1	Homo sapiens	114-119
30997707-2	2019	Herein we report the activation of a non-heme FeIII -OOH intermediate in a synthetic monoiron system using FeIII (OTf)3 to form a high-valent oxidant capable of effecting cyclohexane and benzene hydroxylation within seconds at -40  C. Our results show that the second iron acts as a Lewis acid to activate the iron-hydroperoxo intermediate, leading to the formation of a powerful FeV =O oxidant-a possible role for the second iron in sMMO.	Iron	268-272	POU class 5 homeobox 1	Homo sapiens	114-119
30878939-4	2019	However, Cd2+ removal efficiency was reduced to 12% and 80% at sixth cycle by Fe0 and Bi/Fe0, respectively.	Iron	89-92	CD2 molecule	Homo sapiens	9-12
30878939-6	2019	The oxidation of Fe0 and Bi/Fe0 yielded electron that played significant role in the conversion of toxic Cd2+ into non-toxic Cd0.	Iron	17-20	CD2 molecule	Homo sapiens	105-108
30878939-6	2019	The oxidation of Fe0 and Bi/Fe0 yielded electron that played significant role in the conversion of toxic Cd2+ into non-toxic Cd0.	Iron	28-31	CD2 molecule	Homo sapiens	105-108
31092704-5	2019	Zinc-induced DMT1 expression and iron absorption were inhibited by siRNA silencing of DMT1.	Iron	33-37	solute carrier family 11 member 2	Homo sapiens	86-90
31092704-12	2019	Based on these findings, we conclude that zinc-induced iron absorption involves elevation of DMT1 expression by stabilization of its mRNA, by a PI3K/IRP2-dependent mechanism.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	93-97
31181103-0	2019	Mathematical modeling of the relocation of the divalent metal transporter DMT1 in the intestinal iron absorption process.	Iron	97-101	solute carrier family 11 member 2	Homo sapiens	74-78
31181103-5	2019	Two phenomenological models are proposed for the iron absorption process: DMT1"s binary switching mechanism model and DMT1"s swinging-mechanism model, which represent the absorption mechanism for iron uptake in intestinal cells.	Iron	49-53	solute carrier family 11 member 2	Homo sapiens	74-78
31181103-5	2019	Two phenomenological models are proposed for the iron absorption process: DMT1"s binary switching mechanism model and DMT1"s swinging-mechanism model, which represent the absorption mechanism for iron uptake in intestinal cells.	Iron	49-53	solute carrier family 11 member 2	Homo sapiens	118-122
31181103-5	2019	Two phenomenological models are proposed for the iron absorption process: DMT1"s binary switching mechanism model and DMT1"s swinging-mechanism model, which represent the absorption mechanism for iron uptake in intestinal cells.	Iron	196-200	solute carrier family 11 member 2	Homo sapiens	118-122
31181103-8	2019	Both models are capable of capturing the kinetics of iron absorption and represent empirical observations, but the DMT1"s swinging-mechanism model exhibits a better correlation with experimental data and is able to capture the regulatory phenomenon of mucosal block.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	115-119
31181103-9	2019	The DMT1 swinging-mechanism model is the first phenomenological model reported to effectively represent the complexity of the iron absorption process, as it can predict the behavior of iron absorption fluxes after challenging cells with an initial dose of iron, and the reduction in iron uptake observed as a result of mucosal block after a second iron dose.	Iron	126-130	solute carrier family 11 member 2	Homo sapiens	4-8
31181103-9	2019	The DMT1 swinging-mechanism model is the first phenomenological model reported to effectively represent the complexity of the iron absorption process, as it can predict the behavior of iron absorption fluxes after challenging cells with an initial dose of iron, and the reduction in iron uptake observed as a result of mucosal block after a second iron dose.	Iron	185-189	solute carrier family 11 member 2	Homo sapiens	4-8
31181103-9	2019	The DMT1 swinging-mechanism model is the first phenomenological model reported to effectively represent the complexity of the iron absorption process, as it can predict the behavior of iron absorption fluxes after challenging cells with an initial dose of iron, and the reduction in iron uptake observed as a result of mucosal block after a second iron dose.	Iron	185-189	solute carrier family 11 member 2	Homo sapiens	4-8
31181103-9	2019	The DMT1 swinging-mechanism model is the first phenomenological model reported to effectively represent the complexity of the iron absorption process, as it can predict the behavior of iron absorption fluxes after challenging cells with an initial dose of iron, and the reduction in iron uptake observed as a result of mucosal block after a second iron dose.	Iron	185-189	solute carrier family 11 member 2	Homo sapiens	4-8
31181103-9	2019	The DMT1 swinging-mechanism model is the first phenomenological model reported to effectively represent the complexity of the iron absorption process, as it can predict the behavior of iron absorption fluxes after challenging cells with an initial dose of iron, and the reduction in iron uptake observed as a result of mucosal block after a second iron dose.	Iron	185-189	solute carrier family 11 member 2	Homo sapiens	4-8
31367318-6	2019	The ether/thioether-functionalized network polymer, PAF-1-ET, exhibits high selectivity for the uptake of iron(ii) and iron(iii) over other physiologically and environmentally relevant metal ions.	Iron	106-110	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	52-57
31367318-6	2019	The ether/thioether-functionalized network polymer, PAF-1-ET, exhibits high selectivity for the uptake of iron(ii) and iron(iii) over other physiologically and environmentally relevant metal ions.	Iron	119-123	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	52-57
31367318-9	2019	Combined with an 8-hydroxyquinoline colorimetric indicator, PAF-1-ET enables the simple and direct determination of the iron(ii) and iron(iii) ion concentrations in these samples, providing a starting point for the design and use of molecularly-functionalized porous materials for potential dual detection and remediation applications.	Iron	120-124	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	60-65
31367318-9	2019	Combined with an 8-hydroxyquinoline colorimetric indicator, PAF-1-ET enables the simple and direct determination of the iron(ii) and iron(iii) ion concentrations in these samples, providing a starting point for the design and use of molecularly-functionalized porous materials for potential dual detection and remediation applications.	Iron	133-137	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	60-65
30630976-0	2019	The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	79-87
30903835-2	2019	The effectiveness of arsenic removal from As(V) solutions using granular activated carbon (GAC) (zero point of charge (ZPC) pH 3.2) and iron incorporated GAC (GAC-Fe) (ZPC pH 8.0) was studied at 25 +- 1  C. The batch study confirmed that GAC-Fe had higher Langmuir adsorption capacity at pH 6 (1.43 mg As/g) than GAC (1.01 mg As/g).	Iron	136-140	glutaminase	Homo sapiens	154-157
31108461-1	2019	In mammals, the iron masterswitch hepcidin efficiently controls iron recycling by the macrophage-liver axis but the exact interplay between macrophages and hepatocytes remains poorly understood.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	34-42
31108461-1	2019	In mammals, the iron masterswitch hepcidin efficiently controls iron recycling by the macrophage-liver axis but the exact interplay between macrophages and hepatocytes remains poorly understood.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	34-42
31213851-11	2019	Conclusion: We demonstrated that DFO could upregulate expression of TfR1 and DMT1 , which enhanced iron uptake via activating IL-6/PI3K/AKT signaling pathway in aggressive TNBCs.	Iron	99-103	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-81
31060353-5	2019	The structural and spectroscopic parameters are consistent with an electronic structure description comprised of a high spin iron(I) center ( SFe = 3/2) engaged in antiferromagnetically coupling with a ligand radical anion ( SPI = -1/2).	Iron	125-129	Spi-1 proto-oncogene	Homo sapiens	225-235
31065631-5	2019	Moderate iron doping improved the degree of oxidation at the surface of CoP nanosheets and preserved the conductive and chemically stabilizing host, thereby enhancing the OER activity.	Iron	9-13	caspase recruitment domain family member 16	Homo sapiens	72-75
31096588-0	2019	Effects of Cast-Iron Surface Texturing on the Anti-Scuffing Performance under Starved Lubrication.	Iron	16-20	calpastatin	Homo sapiens	11-15
31096588-2	2019	The potential of using micro-textures machined on the whole stroke of a cast-iron cylinder liner was investigated in this work.	Iron	77-81	calpastatin	Homo sapiens	72-76
31090790-2	2019	Hepcidin negatively regulates iron absorption and release.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
31090790-3	2019	An increase in hepcidin occurs when iron levels are sufficient or in inflammatory states, conditions often associated with hyperferritinemia.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	15-23
30759996-2	2019	BOLA3 (BolA Family Member 3) regulates Fe-S biogenesis, and mutations in BOLA3 result in multiple mitochondrial dysfunction syndrome, a fatal disorder associated with PH.	Iron	39-43	bolA family member 3	Homo sapiens	0-5
30759996-2	2019	BOLA3 (BolA Family Member 3) regulates Fe-S biogenesis, and mutations in BOLA3 result in multiple mitochondrial dysfunction syndrome, a fatal disorder associated with PH.	Iron	39-43	bolA family member 3	Homo sapiens	7-27
30759996-8	2019	In vitro gain- and loss-of-function studies demonstrated that BOLA3 regulated Fe-S integrity, thus modulating lipoate-containing 2-oxoacid dehydrogenases with consequent control over glycolysis and mitochondrial respiration.	Iron	78-82	bolA family member 3	Homo sapiens	62-67
30759996-13	2019	CONCLUSIONS: BOLA3 acts as a crucial lynchpin connecting Fe-S-dependent oxidative respiration and glycine homeostasis with endothelial metabolic reprogramming critical to PH pathogenesis.	Iron	57-59	bolA family member 3	Homo sapiens	13-18
30027366-8	2019	These results suggested that excess dietary iron leads to reduced mass, increased fasting glucose, decreased adiponectin level, and enhancement of insulin resistance, which indicated a multifactorial role of excess iron in the development of diabetes in the setting of obesity.	Iron	44-48	adiponectin, C1Q and collagen domain containing	Mus musculus	109-120
30907175-3	2019	Our understanding of the molecular control of iron metabolism has improved dramatically because of the discovery of hepcidin and attempts to introduce new drugs to stimulate erythropoiesis or affect the hepcidin-ferroportin pathway have recently emerged.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	116-124
30907175-3	2019	Our understanding of the molecular control of iron metabolism has improved dramatically because of the discovery of hepcidin and attempts to introduce new drugs to stimulate erythropoiesis or affect the hepcidin-ferroportin pathway have recently emerged.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	203-211
30907175-7	2019	Expert opinion: Hepcidin is a key regulator of iron availability and is a potential future therapeutic target for managing anemia that is associated with CKD.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	16-24
30765134-10	2019	It was also found that TNF-alpha, GM-CSF and IFN-gamma productions from monocytes/macrophages of thalassemia patients who received iron chelator treatment were significantly higher than those produced from thalassemia patients without iron chelator treatment.	Iron	131-135	colony stimulating factor 2	Homo sapiens	34-40
30968565-11	2019	CONCLUSION: In cost constraints settings, a simple investigation like Ret He alone or with serum ferritin can help us to diagnose and differentiate between the different types of anemia accompanying rheumatological disorders without doing other serum iron studies and expensive tests like transferrin receptor protein which are not readily available.	Iron	251-255	ret proto-oncogene	Homo sapiens	70-73
30797969-0	2019	Iron-induced oxidative stress contributes to alpha-synuclein phosphorylation and up-regulation via polo-like kinase 2 and casein kinase 2.	Iron	0-4	synuclein alpha	Homo sapiens	45-60
30797969-0	2019	Iron-induced oxidative stress contributes to alpha-synuclein phosphorylation and up-regulation via polo-like kinase 2 and casein kinase 2.	Iron	0-4	polo like kinase 2	Homo sapiens	99-117
30797969-4	2019	We previously reported iron up-regulated alpha-synuclein mRNA levels and induced alpha-synuclein aggregation.	Iron	23-27	synuclein alpha	Homo sapiens	41-56
30797969-4	2019	We previously reported iron up-regulated alpha-synuclein mRNA levels and induced alpha-synuclein aggregation.	Iron	23-27	synuclein alpha	Homo sapiens	81-96
30797969-5	2019	In the present study, we aimed to investigate whether and how phosphorylation was involved in iron-induced alpha-synuclein regulations.	Iron	94-98	synuclein alpha	Homo sapiens	107-122
30797969-6	2019	The results showed that iron could induce pS129 alpha-synuclein (phosphorylation at Ser129) and alpha-synuclein upregulation in the substantia nigra of iron-overloaded rats and iron-treated SH-SY5Y cells, accompanied by the elevated levels of polo-like kinase 2 (PLK2) and casein kinase 2 (CK2).	Iron	24-28	polo like kinase 2	Homo sapiens	243-261
30797969-6	2019	The results showed that iron could induce pS129 alpha-synuclein (phosphorylation at Ser129) and alpha-synuclein upregulation in the substantia nigra of iron-overloaded rats and iron-treated SH-SY5Y cells, accompanied by the elevated levels of polo-like kinase 2 (PLK2) and casein kinase 2 (CK2).	Iron	24-28	polo like kinase 2	Homo sapiens	263-267
30797969-7	2019	Over-expression of CK2 or PLK2 induced pS129 alpha-synuclein up-regulation and inhibitors of CK2 or PLK2 could suppress iron-induced alpha-synuclein phosphorylation.	Iron	120-124	polo like kinase 2	Homo sapiens	26-30
30797969-7	2019	Over-expression of CK2 or PLK2 induced pS129 alpha-synuclein up-regulation and inhibitors of CK2 or PLK2 could suppress iron-induced alpha-synuclein phosphorylation.	Iron	120-124	synuclein alpha	Homo sapiens	45-60
30797969-7	2019	Over-expression of CK2 or PLK2 induced pS129 alpha-synuclein up-regulation and inhibitors of CK2 or PLK2 could suppress iron-induced alpha-synuclein phosphorylation.	Iron	120-124	polo like kinase 2	Homo sapiens	100-104
30797969-7	2019	Over-expression of CK2 or PLK2 induced pS129 alpha-synuclein up-regulation and inhibitors of CK2 or PLK2 could suppress iron-induced alpha-synuclein phosphorylation.	Iron	120-124	synuclein alpha	Homo sapiens	133-148
30797969-8	2019	Antioxidant NAC could fully block iron-induced upregulation of CK2, PLK2 and pS129 alpha-synuclein levels, indicating oxidative stress plays a critical role in iron-induced alpha-synuclein phosphorylation.	Iron	34-38	synuclein alpha	Homo sapiens	12-15
31276102-0	2019	Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.	Iron	14-18	bone morphogenetic protein 6	Mus musculus	72-76
30923957-9	2019	Low level of serum iron was related to high level of serum hepcidin (r = - 0.472, p = 0.001).	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	59-67
30923957-11	2019	This study indicated that in MPO-AAV without kidney dysfunction or hemorrhage, the existence of anemia is associated with high level of hepcidin which induces low serum iron and the abnormality of iron utilization.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	136-144
30923957-11	2019	This study indicated that in MPO-AAV without kidney dysfunction or hemorrhage, the existence of anemia is associated with high level of hepcidin which induces low serum iron and the abnormality of iron utilization.	Iron	197-201	hepcidin antimicrobial peptide	Homo sapiens	136-144
31052156-0	2019	Aerosolized Bovine Lactoferrin Counteracts Infection, Inflammation and Iron Dysbalance in A Cystic Fibrosis Mouse Model of Pseudomonas aeruginosa Chronic Lung Infection.	Iron	71-75	lactotransferrin	Bos taurus	19-30
30996139-7	2019	Consequently, classical monocytes displayed superior scavenging capabilities of potentially toxic NTBI, which were augmented by blocking iron export via hepcidin.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	153-161
31024241-1	2019	Aceruloplasminemia (ACP) is a rare, adult-onset, autosomal recessive disorder, characterized by systemic iron overload due to mutations in the Ceruloplasmin gene (CP), which in turn lead to absence or strong reduction of CP activity.	Iron	105-109	ceruloplasmin	Homo sapiens	143-156
30931929-0	2019	Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway.	Iron	0-4	cyclin dependent kinase 1	Homo sapiens	15-19
30931929-0	2019	Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway.	Iron	0-4	interleukin 6 cytokine family signal transducer	Homo sapiens	80-85
30931929-2	2019	Iron directly binds CDK1, which is upregulated in several cancers, thereby promoting JAK1 phosphorylation and activation of STAT3 signaling to promote colorectal carcinogenesis.	Iron	0-4	cyclin dependent kinase 1	Homo sapiens	20-24
30931929-4	2019	We found that iron-dependent CDK1 activity upregulated IL-6 receptor subunit GP130 post-transcriptionally via phosphorylation of 4E-BP1, which is critical for activation of JAK/STAT3 signaling.	Iron	14-18	cyclin dependent kinase 1	Homo sapiens	29-33
30931929-4	2019	We found that iron-dependent CDK1 activity upregulated IL-6 receptor subunit GP130 post-transcriptionally via phosphorylation of 4E-BP1, which is critical for activation of JAK/STAT3 signaling.	Iron	14-18	interleukin 6 cytokine family signal transducer	Homo sapiens	77-82
30931929-4	2019	We found that iron-dependent CDK1 activity upregulated IL-6 receptor subunit GP130 post-transcriptionally via phosphorylation of 4E-BP1, which is critical for activation of JAK/STAT3 signaling.	Iron	14-18	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	129-135
30931929-5	2019	CDK1 and STAT3 are essential for iron-mediated colony formation in lung cancer cell lines.	Iron	33-37	cyclin dependent kinase 1	Homo sapiens	0-4
30931929-6	2019	CDK1 knockdown and iron chelator DFO decreased tumorigenicity and GP130/STAT3 signaling in vivo.	Iron	19-23	interleukin 6 cytokine family signal transducer	Homo sapiens	66-71
30931929-8	2019	Altogether, the present results suggest that CDK1 inhibition and iron deprivation are potential strategies to target GP130/STAT3 signaling to suppress lung cancer.	Iron	65-69	interleukin 6 cytokine family signal transducer	Homo sapiens	117-122
31050203-4	2019	In addition to elevated levels of proteins known to be involved in ATP metabolic processes, our results identified increased levels of mitoNEET (Cisd1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics.	Iron	156-160	CDGSH iron sulfur domain 1	Homo sapiens	135-143
31050203-4	2019	In addition to elevated levels of proteins known to be involved in ATP metabolic processes, our results identified increased levels of mitoNEET (Cisd1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics.	Iron	156-160	CDGSH iron sulfur domain 1	Homo sapiens	145-150
30132882-4	2019	We demonstrated that the iron exporter ferroportin 1 (FPN1) and iron importer divalent metal transporter 1 (DMT1) were upregulated and iron content was decreased after estrogen treatment for 12 hr in primary cultured astrocytes.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	78-106
30132882-4	2019	We demonstrated that the iron exporter ferroportin 1 (FPN1) and iron importer divalent metal transporter 1 (DMT1) were upregulated and iron content was decreased after estrogen treatment for 12 hr in primary cultured astrocytes.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	108-112
30997352-0	2019	Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C. Background and Objective: Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	133-141
30997352-5	2019	Results: The level of hepcidin and its expression together with vitamin D and hepcidin-to-ferritin (H/F) ratios were significantly reduced in patients, but the iron and ferritin levels were higher (P&lt;0.001).	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	22-30
30997352-6	2019	Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H/F ratio (r = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (r = -0.37).	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	6-14
30944864-0	2019	Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	29-37
30944864-0	2019	Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	29-37
30944864-2	2019	We studied the contribution of hepcidin-mediated iron blockade to IDA in African children.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	31-39
31807618-1	2019	The Fbxl5 gene is a member of the F-BOX family and plays an important role in maintaining iron homeostasis in cells.	Iron	90-94	F-box and leucine rich repeat protein 5	Gallus gallus	4-9
30647129-1	2019	Iron efflux from mammalian cells is supported by the synergistic actions of the ferrous iron efflux transporter, ferroportin (Fpn) and a multicopper ferroxidase, that is, hephaestin (Heph), ceruloplasmin (Cp) or both.	Iron	0-4	ceruloplasmin	Homo sapiens	190-203
30874600-3	2019	Treatment of primary adult and neonatal cardiomyocytes as well as H9c2 cells with iron decreased insulin sensitivity determined via Western blotting or immunofluorescent detection of Akt and p70S6K phosphorylation and glucose uptake.	Iron	82-86	ribosomal protein S6 kinase B1	Rattus norvegicus	191-197
30874600-6	2019	Western blotting for LC3-I, LC3-II and P62 levels as well as immunofluorescent co-detection of autophagosomes with Cyto-ID and lysosomal cathepsin activity indicated that iron attenuated autophagic flux without altering total expression of Atg7 or beclin-1 and phosphorylation of mTORC1 and ULK1.	Iron	171-175	autophagy related 7	Rattus norvegicus	240-244
30996848-0	2019	Studying anemia of chronic disease and iron deficiency in patients with rheumatoid arthritis by iron status and circulating hepcidin.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	124-132
30996848-2	2019	Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	106-114
30996848-2	2019	Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	106-114
30996848-2	2019	Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	106-114
30836628-7	2019	(3) Results: A one unit increase in neonatal WB-Iron was associated with a 38% decrease in mean interleukin (IL)-6 levels (0.62; 95% CI: 0.40-0.95, p = 0.03), and a 37% decrease in mean MBL levels (0.63; 95% CI: 0.41-0.95, p = 0.03), but was not statistically significant after correction for multiple testing.	Iron	48-52	mannose binding lectin 2	Homo sapiens	186-189
30836628-8	2019	(4) Conclusions: In summary, we found that higher neonatal WB-iron content was inversely associated with IL-6 and MBL, which may increase susceptibility to infections.	Iron	62-66	mannose binding lectin 2	Homo sapiens	114-117
30868856-0	2019	Serum Hepcidin Levels Predict Intestinal Iron Absorption in Patients with Inflammatory Bowel Disease.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	6-14
30868856-1	2019	BACKGROUND: Hepcidin has been shown to be inversely associated with iron absorption and the expression of iron transport proteins in healthy females and patients with iron deficiency.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	12-20
30868856-1	2019	BACKGROUND: Hepcidin has been shown to be inversely associated with iron absorption and the expression of iron transport proteins in healthy females and patients with iron deficiency.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	12-20
30868856-2	2019	Data describing the relationship between hepcidin expression and iron absorption in patients with inflammatory bowel disease (IBD) are lacking.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	41-49
30868856-3	2019	The objective of this study was to assess the relationship between serum concentrations of hepcidin and iron absorption in patients with IBD and iron deficiency by means of an oral iron absorption test.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	91-99
30868856-3	2019	The objective of this study was to assess the relationship between serum concentrations of hepcidin and iron absorption in patients with IBD and iron deficiency by means of an oral iron absorption test.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	91-99
30868856-8	2019	When the two markers are compared, in our analysis, serum hepcidin levels (AUC: 0.817) tended to predict iron malabsorption slightly better than serum ferritin (AUC: 0.788).	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	58-66
30868856-9	2019	CONCLUSIONS: The evidence from our study suggests that serum hepcidin levels are a promising predictor of absorptive capacity in patients treated with oral iron compounds.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	61-69
30266679-2	2019	Proteins such as alpha-synuclein, tau and amyloid precursor protein that are pathologically associated with neurodegeneration are involved in molecular crosstalk with iron homeostatic proteins.	Iron	167-171	synuclein alpha	Homo sapiens	17-32
30266679-2	2019	Proteins such as alpha-synuclein, tau and amyloid precursor protein that are pathologically associated with neurodegeneration are involved in molecular crosstalk with iron homeostatic proteins.	Iron	167-171	microtubule associated protein tau	Homo sapiens	34-37
30622138-5	2019	The milk of TMEM165-deficient mice contained elevated concentrations of fat, protein, iron, and zinc, which are likely caused by decreased osmosis-mediated dilution of the milk caused by the decreased biosynthesis of lactose.	Iron	86-90	transmembrane protein 165	Mus musculus	12-19
30693979-8	2019	In conclusion, Fe-Gly (60 mg Fe/kg) had improved laying rate, egg weight, SOD enzyme activity, Fe absorption and protein synthesis in body and promoted iron metabolism in laying hens.	Iron	15-17	superoxide dismutase 1, soluble	Gallus gallus	74-77
30363006-1	2019	PURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	158-166
30936776-1	2019	Purpose: Hepcidin is an acute-phase protein involved also in regulation of iron homeostasis.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	9-17
30813537-0	2019	Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	64-68
30813537-2	2019	The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and determine their iron transport.	Iron	189-193	solute carrier family 11 member 2	Homo sapiens	4-32
30813537-2	2019	The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and determine their iron transport.	Iron	189-193	solute carrier family 11 member 2	Homo sapiens	34-38
30813537-2	2019	The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and determine their iron transport.	Iron	219-223	solute carrier family 11 member 2	Homo sapiens	4-32
30813537-2	2019	The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and determine their iron transport.	Iron	219-223	solute carrier family 11 member 2	Homo sapiens	34-38
30813537-4	2019	DMT1-knockout suppressed the synthesis of ferritin and inhibited the response of iron regulatory protein 1 (IRP-1) and IRP-2 to these two iron sources.	Iron	81-85	solute carrier family 11 member 2	Homo sapiens	0-4
30813537-7	2019	These results indicated that iron from Fe-Gly was probably mainly transported into enterocytes via DMT1 like FeSO4; Zip14 may play a certain role in the intestinal iron transport.	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	99-103
30791479-3	2019	Several factors have been found to trigger alpha-syn aggregation, including raised calcium, iron, and copper.	Iron	92-96	synuclein alpha	Homo sapiens	43-52
30760223-0	2019	Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice.	Iron	53-57	olfactory receptor family 10 subfamily N member 1	Mus musculus	68-71
30760223-4	2019	METHODS: In the present study, we investigated the potential role of a multi-target iron chelator, M30 in protecting against cyclophosphamide-induced alopecia in C57BL/6 mice implanted with an osmotic pump.	Iron	84-88	olfactory receptor family 10 subfamily N member 1	Mus musculus	99-102
30809110-8	2019	Here, we review the multiple cell-damaging responses generated by the unregulated iron/calcium self-feeding cycle, such as excitotoxicity, free radical-mediated lipid peroxidation, and the oxidative modification of crucial components of iron and calcium homeostasis/signaling: the iron transporter DMT1, plasma membrane, and intracellular calcium channels and pumps.	Iron	82-86	doublesex and mab-3 related transcription factor 1	Homo sapiens	298-302
30734101-5	2019	Higher amounts of Cd, Pb, Cu, Mn, and Fe were determined in rivers discharging sediments into the sea.	Iron	38-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
30728365-8	2019	We hypothesize that decreased expression of miR-148a in HCC may elevate transferrin-bound iron uptake, increasing cellular iron levels and cell proliferation.	Iron	123-127	microRNA 148a	Homo sapiens	44-52
30394565-3	2019	These adjustments are thought to be in large part mediated by the iron-regulatory hormone hepcidin, which controls the concentrations of ferroportin, the sole exporter of iron into the extracellular fluid and blood plasma.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	90-98
30394565-4	2019	Hepcidin regulation of iron availability during healthy and abnormal pregnancies is not well understood.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
30394565-7	2019	The second trimester hepcidin levels decreased despite stable serum iron concentrations, suggesting active suppression of hepcidin, presumably to enhance iron availability as iron demand increases.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	21-29
30394565-7	2019	The second trimester hepcidin levels decreased despite stable serum iron concentrations, suggesting active suppression of hepcidin, presumably to enhance iron availability as iron demand increases.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	122-130
30394565-7	2019	The second trimester hepcidin levels decreased despite stable serum iron concentrations, suggesting active suppression of hepcidin, presumably to enhance iron availability as iron demand increases.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	21-29
30394565-7	2019	The second trimester hepcidin levels decreased despite stable serum iron concentrations, suggesting active suppression of hepcidin, presumably to enhance iron availability as iron demand increases.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	122-130
30128746-8	2019	Interestingly, the mammalian Cth2 ortholog known as tristetraprolin (aka TTP/TIS11/ZFP36), which is also implicated in controlling iron metabolism, promotes the decay and prevents the translation of its regulated transcripts.	Iron	131-135	Tis11p	Saccharomyces cerevisiae S288C	29-33
30247984-2	2019	Mutations in the FPN1 gene, encoding a cell surface iron exporter [ferroportin (Fpn)], are responsible for hemochromatosis type 4, also known as ferroportin disease.	Iron	52-56	solute carrier family 40 member 1	Homo sapiens	17-21
30312834-2	2019	TF receptors (TFRC and TFR2) regulate intracellular iron by delivering iron from TF into the cytoplasm.	Iron	52-56	transferrin receptor 2	Homo sapiens	23-27
30312834-2	2019	TF receptors (TFRC and TFR2) regulate intracellular iron by delivering iron from TF into the cytoplasm.	Iron	71-75	transferrin receptor 2	Homo sapiens	23-27
30312834-8	2019	Among the 10 SNPs in TF, TFRC, and TFR2 genes, significant associations were observed between TF genotypes (rs12769) and male iron concentrations.	Iron	126-130	transferrin receptor 2	Homo sapiens	35-39
30296579-11	2019	Mk1 increased the IC50 values for lead, copper, and iron by 1.3, 1.8 and 1.7 times, respectively.	Iron	52-56	potassium voltage-gated channel subfamily A member 1	Homo sapiens	0-3
30296579-12	2019	CONCLUSIONS: Mj1 is suggested as a lead compound for developing therapeutic agents for lead (Pb) toxicity and Mk1 for copper and iron.	Iron	129-133	potassium voltage-gated channel subfamily A member 1	Homo sapiens	110-113
30173950-4	2019	Hemochromatoses, mostly but not exclusively related to the HFE gene, correspond to systemic iron overload of genetic origin in which iron excess is the consequence of hepcidin deficiency, hepcidin being the hormone regulating negatively plasma iron.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	188-196
30173950-4	2019	Hemochromatoses, mostly but not exclusively related to the HFE gene, correspond to systemic iron overload of genetic origin in which iron excess is the consequence of hepcidin deficiency, hepcidin being the hormone regulating negatively plasma iron.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	167-175
30173950-4	2019	Hemochromatoses, mostly but not exclusively related to the HFE gene, correspond to systemic iron overload of genetic origin in which iron excess is the consequence of hepcidin deficiency, hepcidin being the hormone regulating negatively plasma iron.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	167-175
30855106-4	2019	Hepcidin switches off cellular iron export via ferroportin-1 and sequesters the metal mainly within macrophages, which limits the transfer of iron to the serum to restrict its availability for extracellular microbes.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
30855106-4	2019	Hepcidin switches off cellular iron export via ferroportin-1 and sequesters the metal mainly within macrophages, which limits the transfer of iron to the serum to restrict its availability for extracellular microbes.	Iron	31-35	solute carrier family 40 member 1	Homo sapiens	47-60
30855106-4	2019	Hepcidin switches off cellular iron export via ferroportin-1 and sequesters the metal mainly within macrophages, which limits the transfer of iron to the serum to restrict its availability for extracellular microbes.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	0-8
30855106-5	2019	When intracellular microbes are present within macrophages though, the opposite regulation is initiated because infected cells respond with increased ferroportin-1 expression and enhanced iron export as a strategy of iron withdrawal from engulfed bacteria.	Iron	217-221	solute carrier family 40 member 1	Homo sapiens	150-163
29402144-1	2019	Aims: Mitochondrial ferritin (protein [FtMt]) is preferentially expressed in cell types of high metabolic activity and oxygen consumption, which is consistent with its role of sequestering iron and preventing oxygen-derived redox damage.	Iron	189-193	ferritin mitochondrial	Homo sapiens	6-28
29402144-1	2019	Aims: Mitochondrial ferritin (protein [FtMt]) is preferentially expressed in cell types of high metabolic activity and oxygen consumption, which is consistent with its role of sequestering iron and preventing oxygen-derived redox damage.	Iron	189-193	ferritin mitochondrial	Homo sapiens	39-43
29402144-5	2019	We also demonstrate that FtMt can alleviate hypoxia-induced brain cell death by sequestering uncommitted iron, whose levels increase with hypoxia in these cells.	Iron	105-109	ferritin mitochondrial	Homo sapiens	25-29
30352047-0	2019	Hepatic hepcidin/intestinal HIF-2alpha axis maintains iron absorption during iron deficiency and overload.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	8-16
30352047-0	2019	Hepatic hepcidin/intestinal HIF-2alpha axis maintains iron absorption during iron deficiency and overload.	Iron	54-58	endothelial PAS domain protein 1	Homo sapiens	28-38
30352047-2	2019	Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls iron mobilization through its molecular target ferroportin (FPN), the only known mammalian iron exporter.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	35-43
30352047-2	2019	Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls iron mobilization through its molecular target ferroportin (FPN), the only known mammalian iron exporter.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	35-43
30352047-2	2019	Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls iron mobilization through its molecular target ferroportin (FPN), the only known mammalian iron exporter.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	35-43
30352047-4	2019	Additionally, intestinal HIF-2alpha is essential for the local absorptive response to systemic iron deficiency and iron overload.	Iron	95-99	endothelial PAS domain protein 1	Homo sapiens	25-35
30352047-5	2019	Our data demonstrate a hetero-tissue crosstalk mechanism, whereby hepatic hepcidin regulated intestinal HIF-2alpha in iron deficiency, anemia, and iron overload.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	74-82
30352047-6	2019	We show that FPN controlled cell-autonomous iron efflux to stabilize and activate HIF-2alpha by regulating the activity of iron-dependent intestinal prolyl hydroxylase domain enzymes.	Iron	44-48	endothelial PAS domain protein 1	Homo sapiens	82-92
30352047-6	2019	We show that FPN controlled cell-autonomous iron efflux to stabilize and activate HIF-2alpha by regulating the activity of iron-dependent intestinal prolyl hydroxylase domain enzymes.	Iron	123-127	endothelial PAS domain protein 1	Homo sapiens	82-92
30352047-7	2019	Pharmacological blockade of HIF-2alpha using a clinically relevant and highly specific inhibitor successfully treated iron overload in a mouse model.	Iron	118-122	endothelial PAS domain protein 1	Mus musculus	28-38
30352047-8	2019	These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2alpha that controls physiological iron uptake and drives iron hyperabsorption during iron overload.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	60-68
30352047-8	2019	These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2alpha that controls physiological iron uptake and drives iron hyperabsorption during iron overload.	Iron	123-127	endothelial PAS domain protein 1	Homo sapiens	84-94
30352047-8	2019	These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2alpha that controls physiological iron uptake and drives iron hyperabsorption during iron overload.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	60-68
30352047-8	2019	These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2alpha that controls physiological iron uptake and drives iron hyperabsorption during iron overload.	Iron	146-150	endothelial PAS domain protein 1	Homo sapiens	84-94
30352047-8	2019	These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2alpha that controls physiological iron uptake and drives iron hyperabsorption during iron overload.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	60-68
30352047-8	2019	These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2alpha that controls physiological iron uptake and drives iron hyperabsorption during iron overload.	Iron	146-150	endothelial PAS domain protein 1	Homo sapiens	84-94
31456203-4	2019	Divalent metal transporter 1 (DMT1) at the apical membrane of intestinal enterocyte brings in non-heme iron from the diet, whereas ferroportin 1 (FPN1) at the basal membrane exports iron into the circulation.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	0-28
31456203-4	2019	Divalent metal transporter 1 (DMT1) at the apical membrane of intestinal enterocyte brings in non-heme iron from the diet, whereas ferroportin 1 (FPN1) at the basal membrane exports iron into the circulation.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	30-34
31456203-4	2019	Divalent metal transporter 1 (DMT1) at the apical membrane of intestinal enterocyte brings in non-heme iron from the diet, whereas ferroportin 1 (FPN1) at the basal membrane exports iron into the circulation.	Iron	182-186	solute carrier family 40 member 1	Homo sapiens	131-144
31456203-4	2019	Divalent metal transporter 1 (DMT1) at the apical membrane of intestinal enterocyte brings in non-heme iron from the diet, whereas ferroportin 1 (FPN1) at the basal membrane exports iron into the circulation.	Iron	182-186	solute carrier family 40 member 1	Homo sapiens	146-150
31456203-6	2019	After binding to transferrin receptor 1 (TfR1), the complex is endocytosed into the cell, where iron enters the cytoplasm via DMT1 on the endosomal membrane.	Iron	96-100	solute carrier family 11 member 2	Homo sapiens	126-130
31456203-8	2019	Excess iron can be exported from the cell via FPN1.	Iron	7-11	solute carrier family 40 member 1	Homo sapiens	46-50
31456203-9	2019	The liver-derived peptide hepcidin plays a major regulatory role in controlling FPN1 level in the enterocyte, and thus controls the whole-body iron absorption.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	26-34
31456203-10	2019	Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs.	Iron	18-22	solute carrier family 11 member 2	Homo sapiens	78-82
31456203-10	2019	Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs.	Iron	18-22	solute carrier family 40 member 1	Homo sapiens	104-108
31456203-10	2019	Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs.	Iron	128-132	solute carrier family 11 member 2	Homo sapiens	78-82
31456203-10	2019	Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs.	Iron	128-132	solute carrier family 40 member 1	Homo sapiens	104-108
31456203-11	2019	Both the release of hepcidin and the IRP-IRE interaction are coordinated with the fluctuation of the cellular iron level.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	20-28
31456205-4	2019	There is emerging evidence on the structural links and functional modulations between iron and alpha-synuclein, and the key player in PD which aggregates in Lewy bodies.	Iron	86-90	synuclein alpha	Homo sapiens	95-110
30252570-0	2019	Mitochondrial quality control mediated by PINK1 and PRKN: links to iron metabolism and tumor immunity.	Iron	67-71	PTEN induced putative kinase 1	Mus musculus	42-47
30814790-6	2019	In addition, serum cystatin-C and beta-2 microglobulin levels were positively correlated with blood urea, serum creatinine, serum ferritin, urinary albumin/creatinine ratio, duration of iron chelating agents and frequency of blood transfusion/year.	Iron	186-190	beta-2-microglobulin	Homo sapiens	34-54
30745811-7	2019	Hepcidin levels and ratios of hepcidin to erythropoietic activity and to iron biomarker levels were lower in patients with beta-thalassemia intermedia or hemoglobin (Hb) E/beta-thalassemia than in patients with HbH disease.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
31055580-4	2019	We found an enrichment of the iron-binding glycoprotein lactoferrin in the urinary exosomes of infected mice.	Iron	30-34	lactotransferrin	Mus musculus	56-67
30402883-0	2019	Hepcidin mediated iron homoeostasis as immune regulator in visceral leishmaniasis patients.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
30402883-4	2019	METHODS AND RESULTS: This study was performed on purified monocytes and T cells, peripheral blood mononuclear cells and splenic aspirates for transcriptional analyses of iron homoeostasis (hepcidin, DMT1, transferrin receptor, ferroportin) and immune modulations (IFN-gamma, HLA-DR, IL-10, iNOS, IL-6).	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	189-197
30009872-1	2019	Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1).	Iron	73-77	heme oxygenase 1	Homo sapiens	127-143
30009872-1	2019	Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1).	Iron	73-77	heme oxygenase 1	Homo sapiens	145-149
30009872-7	2019	A comprehensive model of astroglial stress is presented wherein sustained Hmox1 induction promotes oxidative mitochondrial membrane damage, iron sequestration and mitophagy (macroautophagy).	Iron	140-144	heme oxygenase 1	Homo sapiens	74-79
30213580-3	2019	Heme oxygenase-1 (HO-1) plays a crucial role in heme degradation and in this way releases carbon monoxide, free iron, and biliverdin.	Iron	112-116	heme oxygenase 1	Homo sapiens	0-16
30213580-3	2019	Heme oxygenase-1 (HO-1) plays a crucial role in heme degradation and in this way releases carbon monoxide, free iron, and biliverdin.	Iron	112-116	heme oxygenase 1	Homo sapiens	18-22
30798807-4	2019	Hepcidin also controls iron release from macrophages that recycle iron and from hepatocytes that store iron.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798807-4	2019	Hepcidin also controls iron release from macrophages that recycle iron and from hepatocytes that store iron.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798807-4	2019	Hepcidin also controls iron release from macrophages that recycle iron and from hepatocytes that store iron.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798807-5	2019	Hepcidin binds to the only known iron export protein, ferroportin, inducing its internalization and degradation and thus limiting the amount of iron released into the plasma.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798807-5	2019	Hepcidin binds to the only known iron export protein, ferroportin, inducing its internalization and degradation and thus limiting the amount of iron released into the plasma.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798807-6	2019	Important regulators of hepcidin, and therefore of systemic iron homeostasis, include plasma iron concentrations, body iron stores, infection and inflammation, hypoxia and erythropoiesis, and, to a lesser extent, testosterone.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	24-32
30798807-6	2019	Important regulators of hepcidin, and therefore of systemic iron homeostasis, include plasma iron concentrations, body iron stores, infection and inflammation, hypoxia and erythropoiesis, and, to a lesser extent, testosterone.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	24-32
30798807-7	2019	Dysregulation of hepcidin production contributes to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and non-transfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic inflammatory diseases and inherited iron-refractory iron-deficiency anemia.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	17-25
30798807-7	2019	Dysregulation of hepcidin production contributes to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and non-transfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic inflammatory diseases and inherited iron-refractory iron-deficiency anemia.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	93-101
30798807-7	2019	Dysregulation of hepcidin production contributes to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and non-transfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic inflammatory diseases and inherited iron-refractory iron-deficiency anemia.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	17-25
30798807-7	2019	Dysregulation of hepcidin production contributes to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and non-transfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic inflammatory diseases and inherited iron-refractory iron-deficiency anemia.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	93-101
30798808-1	2019	Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorption and reticuloendothelial sequestration of iron by interacting with ferroportin.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798808-1	2019	Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorption and reticuloendothelial sequestration of iron by interacting with ferroportin.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798809-1	2019	Hepcidin expression is determined through transcriptional regulation by systemic iron status.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798809-2	2019	However, acute or chronic inflammation also increases the expression of hepcidin, which is associated with the dysregulation of iron metabolism in pathological conditions.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	72-80
30798809-7	2019	Relationships between increased production of IL-1beta and dysregulated iron metabolism have been suggested in various diseases, which may be linked to overproduction of hepcidin.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	170-178
30798810-1	2019	Hepcidin is considered the major regulator of systemic iron homeostasis in human and mice, and its expression in the liver is mainly regulated at a transcriptional level.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
30798811-1	2019	Hepcidin is central to regulation of iron metabolism.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
30366982-0	2018	FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.	Iron	104-108	erythropoietin	Mus musculus	14-28
30366982-2	2018	Despite the centrality of iron metabolism to erythropoiesis, the mechanisms by which EPO regulates iron status are not well-understood.	Iron	99-103	erythropoietin	Mus musculus	85-88
30366982-3	2018	To this end, here we profiled gene expression in EPO-treated 32D pro-B cells and developing fetal liver erythroid cells to identify additional iron regulatory genes.	Iron	143-147	erythropoietin	Mus musculus	49-52
30366982-10	2018	Collectively, our results reveal a critical mechanism by which EPO signaling regulates terminal erythropoiesis and iron metabolism.	Iron	115-119	erythropoietin	Mus musculus	63-66
30881642-1	2019	We took advantage of the iron binding affinity of apoferritin to immobilize iron-sulfur clusters into apoferritin up to 312 moieties per protein, with a loading rate as high as 25 wt%.	Iron	25-29	ferritin heavy chain 1	Homo sapiens	50-61
30881642-1	2019	We took advantage of the iron binding affinity of apoferritin to immobilize iron-sulfur clusters into apoferritin up to 312 moieties per protein, with a loading rate as high as 25 wt%.	Iron	25-29	ferritin heavy chain 1	Homo sapiens	102-113
30881642-1	2019	We took advantage of the iron binding affinity of apoferritin to immobilize iron-sulfur clusters into apoferritin up to 312 moieties per protein, with a loading rate as high as 25 wt%.	Iron	76-80	ferritin heavy chain 1	Homo sapiens	50-61
30881642-1	2019	We took advantage of the iron binding affinity of apoferritin to immobilize iron-sulfur clusters into apoferritin up to 312 moieties per protein, with a loading rate as high as 25 wt%.	Iron	76-80	ferritin heavy chain 1	Homo sapiens	102-113
30555055-0	2018	Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.	Iron	7-11	telomerase RNA component	Mus musculus	42-46
30555055-0	2018	Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.	Iron	7-11	telomerase reverse transcriptase	Mus musculus	50-54
30555055-4	2018	Correlation analysis showed that tissue iron is negatively correlated with TERT and TERC expression in the liver, kidney and heart of parabiotic mice.	Iron	40-44	telomerase reverse transcriptase	Mus musculus	75-79
30555055-4	2018	Correlation analysis showed that tissue iron is negatively correlated with TERT and TERC expression in the liver, kidney and heart of parabiotic mice.	Iron	40-44	telomerase RNA component	Mus musculus	84-88
30415773-1	2018	BACKGROUND INFORMATION: Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR1) are vital proteins for cellular iron uptake.	Iron	124-128	solute carrier family 11 member 2	Homo sapiens	24-52
30415773-1	2018	BACKGROUND INFORMATION: Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR1) are vital proteins for cellular iron uptake.	Iron	124-128	solute carrier family 11 member 2	Homo sapiens	54-58
30415773-3	2018	Besides, iron regulatory protein 1 (IRP1) regulates DMT1 and TfR1 by binding to iron-responsive elements (IREs) present in their mRNAs to control cellular iron homeostasis.	Iron	9-13	solute carrier family 11 member 2	Homo sapiens	52-56
30415773-3	2018	Besides, iron regulatory protein 1 (IRP1) regulates DMT1 and TfR1 by binding to iron-responsive elements (IREs) present in their mRNAs to control cellular iron homeostasis.	Iron	80-84	solute carrier family 11 member 2	Homo sapiens	52-56
30415773-5	2018	Ferrous iron uptake was elevated by DMT1(+IRE) and TfR1 under acute hypoxia.	Iron	0-12	solute carrier family 11 member 2	Homo sapiens	36-40
30568573-3	2018	Ceruloplasmin is a ferroxidase that plays a critical role in iron homeostasis through the oxidation and mobilization of iron from stores and subsequent incorporation of ferric iron into transferrin (Tf), which becomes available for cellular uptake via the Tf receptor.	Iron	61-65	ceruloplasmin	Homo sapiens	0-13
30568573-3	2018	Ceruloplasmin is a ferroxidase that plays a critical role in iron homeostasis through the oxidation and mobilization of iron from stores and subsequent incorporation of ferric iron into transferrin (Tf), which becomes available for cellular uptake via the Tf receptor.	Iron	120-124	ceruloplasmin	Homo sapiens	0-13
30351387-3	2018	Objective: We hypothesized that 3 wk of exercise training in recreational male runners would decrease oral iron bioavailability by increasing inflammation and hepcidin concentrations.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	159-167
30178146-0	2018	Response to Letter to the Editor: "Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet"".	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	53-61
30339884-1	2018	Glutathione peroxidase 4 (GPX4) is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death); its inhibition can render therapy-resistant cancer cells susceptible to ferroptosis.	Iron	63-67	glutathione peroxidase 4	Homo sapiens	0-24
30339884-1	2018	Glutathione peroxidase 4 (GPX4) is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death); its inhibition can render therapy-resistant cancer cells susceptible to ferroptosis.	Iron	63-67	glutathione peroxidase 4	Homo sapiens	26-30
30145824-2	2018	Bach1 is a mammalian transcription factor that represses Hmox1, which encodes heme oxygenase-1 (HO-1) that can degrade heme into free iron, carbon monoxide, and biliverdin, to play an important role in antioxidant, anti-inflammatory, and antiapoptotic activities.	Iron	134-138	heme oxygenase 1	Homo sapiens	78-94
30145824-2	2018	Bach1 is a mammalian transcription factor that represses Hmox1, which encodes heme oxygenase-1 (HO-1) that can degrade heme into free iron, carbon monoxide, and biliverdin, to play an important role in antioxidant, anti-inflammatory, and antiapoptotic activities.	Iron	134-138	heme oxygenase 1	Homo sapiens	96-100
30031257-1	2018	A new bimetallic Co/Fe-MOF was synthesized and phosphatized to produce a visible-light-active Co/Fe binary metal phosphide embedded in a mesoporous carbon matrix (denoted by CoP/Fe2P@mC).	Iron	20-22	caspase recruitment domain family member 16	Homo sapiens	174-177
30486249-2	2018	This gene controls the expression of hepcidin, a peptide secreted in plasma by the liver and regulates systemic iron distribution.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	37-45
30486249-3	2018	Homozygous C282Y mutation induces hepcidin deficiency, leading to increased circulating transferrin saturation, and ultimately, iron accumulation in organs such as the liver, pancreas, heart, and bone.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	34-42
30467279-8	2018	However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron.	Iron	195-199	hepcidin antimicrobial peptide	Homo sapiens	129-137
30467279-9	2018	New iron supplements are considered herein with the aim to combine the improvement of hematological status, blunting of hepcidin expression, and minimizing the toxicity of the administered iron.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	120-128
30584425-6	2018	On the other hand, iron overload increased IL6 and reduced IL10 in small intestinal tissues reflecting inflammatory condition and increased caspase 3 reactivity indicating apoptosis and increased iNOs expressing cell indicting oxidative stress especially in ileum.	Iron	19-23	interleukin 10	Rattus norvegicus	59-63
30383537-4	2018	Specifically, Fe stimulated the expression of mPGES-1 and the production of PGE2 and PGD2 via the Tf and TfR system.	Iron	14-16	prostaglandin E synthase	Mus musculus	46-53
30269025-1	2018	Hepcidin, a liver-derived hormone, negatively regulates circulating iron levels through an increase in its expression in response to iron overload.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
30269025-1	2018	Hepcidin, a liver-derived hormone, negatively regulates circulating iron levels through an increase in its expression in response to iron overload.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	0-8
30002125-2	2018	It is an autosomal dominant disorder, primarily due to missense mutations in SLC40A1 This gene encodes ferroportin 1 (FPN1), which is the sole iron export protein reported in mammals.	Iron	143-147	solute carrier family 40 member 1	Homo sapiens	77-84
30002125-2	2018	It is an autosomal dominant disorder, primarily due to missense mutations in SLC40A1 This gene encodes ferroportin 1 (FPN1), which is the sole iron export protein reported in mammals.	Iron	143-147	solute carrier family 40 member 1	Homo sapiens	103-116
30002125-2	2018	It is an autosomal dominant disorder, primarily due to missense mutations in SLC40A1 This gene encodes ferroportin 1 (FPN1), which is the sole iron export protein reported in mammals.	Iron	143-147	solute carrier family 40 member 1	Homo sapiens	118-122
30002125-10	2018	In vitro experiments demonstrated that the p.Arg178Gln mutant reduces the ability of FPN1 to export iron without causing protein mislocalization.	Iron	100-104	solute carrier family 40 member 1	Homo sapiens	85-89
30002125-11	2018	Based on a comparative model of the 3D structure of human FPN1 in an outward facing conformation, we argue that p.Arg178 is part of an interaction network modulating the conformational changes required for iron transport.	Iron	206-210	solute carrier family 40 member 1	Homo sapiens	58-62
30247706-8	2018	Cord hepcidin had the greatest association with cord iron indicators because cord hepcidin alone captured 63.8%, 48.4%, 44.4%, and 31.3% of the intrauterine variance in cord hemoglobin, SF, sTfR, and EPO, respectively, whereas maternal hepcidin had no effect on cord iron indicators.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	5-13
30247706-8	2018	Cord hepcidin had the greatest association with cord iron indicators because cord hepcidin alone captured 63.8%, 48.4%, 44.4%, and 31.3% of the intrauterine variance in cord hemoglobin, SF, sTfR, and EPO, respectively, whereas maternal hepcidin had no effect on cord iron indicators.	Iron	267-271	hepcidin antimicrobial peptide	Homo sapiens	5-13
30247706-11	2018	Conclusions: In summary, fetally derived hepcidin might have more control on intrauterine variance in iron indicators than maternal hepcidin and appears to be capable of regulating fetal iron status independently of maternal hepcidin.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	41-49
30247706-11	2018	Conclusions: In summary, fetally derived hepcidin might have more control on intrauterine variance in iron indicators than maternal hepcidin and appears to be capable of regulating fetal iron status independently of maternal hepcidin.	Iron	187-191	hepcidin antimicrobial peptide	Homo sapiens	41-49
30140071-8	2018	Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% CI) -4.2 pg/L (-6.1 to -2.4) and at 12 months mean difference (95% CI) -3.4 pg/L (-5.0 to -1.8).	Iron	37-41	ret proto-oncogene	Homo sapiens	0-3
30140071-9	2018	CONCLUSIONS: This longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.	Iron	101-105	ret proto-oncogene	Homo sapiens	46-49
29952128-1	2018	Metal ion transporters of the Zrt- and Irt-like protein (ZIP, or SLC39A) family transport zinc, iron, manganese and/or cadmium across cellular membranes and into the cytosol.	Iron	96-100	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	30-55
29952128-1	2018	Metal ion transporters of the Zrt- and Irt-like protein (ZIP, or SLC39A) family transport zinc, iron, manganese and/or cadmium across cellular membranes and into the cytosol.	Iron	96-100	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	57-60
30360575-6	2018	Representing Hepc modulation an effective approach to correct iron balance impairment in common human diseases, and with Tfr2 being one of its regulators, it would be worthwhile to envisage Tfr2 as a therapeutic target.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	13-17
29850741-3	2018	In this study, several Ru and Fe complexes containing two terminal quadruple hydrogen-bonded (H-bonded) ureidopyrimidinedione (UPy) groups were synthesized (Ru-1, Ru-UPy, and Fe-UPy) to form H-bonded supramolecular polymers by self-association.	Iron	30-32	Scm like with four mbt domains 1	Homo sapiens	157-161
29850741-4	2018	In order to control the solubility of these complexes in nonpolar solvents, Ru-UPy and Fe-UPy were endowed with long alkyl side chain groups in the coordinated 2,6-bis(benzimidazol-2-yl)pyridine ligand, while Ru-1 and Ru-2 do not contain such long alkyl chain groups.	Iron	87-89	Scm like with four mbt domains 1	Homo sapiens	209-213
29850741-4	2018	In order to control the solubility of these complexes in nonpolar solvents, Ru-UPy and Fe-UPy were endowed with long alkyl side chain groups in the coordinated 2,6-bis(benzimidazol-2-yl)pyridine ligand, while Ru-1 and Ru-2 do not contain such long alkyl chain groups.	Iron	87-89	doublecortin domain containing 2	Homo sapiens	218-222
28477161-10	2018	It likely reflected a simultaneous release of As and S(II) in sediments by synchronous reduction of As-hosted oxidized iron and sulfate, respectively.	Iron	119-123	transcription elongation factor A1	Homo sapiens	53-58
29903760-2	2018	As this molecule influences the production of the iron regulatory hormone hepcidin, we hypothesized that erythropoiesis-driven changes in diferric transferrin levels could contribute to the decrease in hepcidin observed following the administration of erythropoietin.	Iron	50-54	erythropoietin	Mus musculus	252-266
29903760-7	2018	Increasing diferric transferrin levels via intravenous iron injection prevented the inhibition of Hamp1 expression by erythropoietin without altering hepatic iron concentration or the expression of Erfe, the gene encoding erythroferrone.	Iron	55-59	erythropoietin	Mus musculus	118-132
30319197-1	2018	Hepcidin is a 25-amino acid peptide hormone produced by hepatocytes and plays a key role in body iron metabolism.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	0-8
30319197-2	2018	Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemia, and its excess is associated with anemia of inflammation, chronic disease and iron deficiency anemia (IDA).	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
30319197-2	2018	Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemia, and its excess is associated with anemia of inflammation, chronic disease and iron deficiency anemia (IDA).	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	0-8
30319197-3	2018	The aims of this study was to evaluate HAMP gene mutation, namely IVS2 + 1(-G) (c.148-150 + 1del) and Gly71 Asp (c.212G &gt; A (rs104894696) association with iron status in IDA conditions.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	39-43
30274354-3	2018	In turn, ID in cancer patients can be due to multiple concurring mechanisms, including bleeding (e.g., in gastrointestinal cancers or after surgery), malnutrition, medications, and hepcidin-driven iron sequestration into macrophages with subsequent iron-restricted erythropoiesis.	Iron	197-201	hepcidin antimicrobial peptide	Homo sapiens	181-189
30274354-3	2018	In turn, ID in cancer patients can be due to multiple concurring mechanisms, including bleeding (e.g., in gastrointestinal cancers or after surgery), malnutrition, medications, and hepcidin-driven iron sequestration into macrophages with subsequent iron-restricted erythropoiesis.	Iron	249-253	hepcidin antimicrobial peptide	Homo sapiens	181-189
30204426-0	2018	The H2O2-Resistant Fe-S Redox Switch MitoNEET Acts as a pH Sensor To Repair Stress-Damaged Fe-S Protein.	Iron	19-23	CDGSH iron sulfur domain 1	Homo sapiens	37-45
30204426-0	2018	The H2O2-Resistant Fe-S Redox Switch MitoNEET Acts as a pH Sensor To Repair Stress-Damaged Fe-S Protein.	Iron	91-95	CDGSH iron sulfur domain 1	Homo sapiens	37-45
29928951-1	2018	Hepcidin is an essential hormone responsible for the systemic metabolism of iron and simultaneously belongs to the family of the protein mediators of the acute inflammatory response, primarily induced in response to interleukin 6.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
30250199-3	2018	Hepcidin secretion from thyroid cancer cells also leads to decreased expression of the iron exporter, ferroportin (FPN), and increased intracellular iron retention, which promote cancer proliferation.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
30250199-3	2018	Hepcidin secretion from thyroid cancer cells also leads to decreased expression of the iron exporter, ferroportin (FPN), and increased intracellular iron retention, which promote cancer proliferation.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	0-8
30250199-10	2018	These findings suggest a new mechanism of cellular iron dysfunction through the E4BP4/G9a/SOSTDC1/hepcidin pathway, which is an essential link in TC.	Iron	51-55	sclerostin domain containing 1	Homo sapiens	90-97
30250199-10	2018	These findings suggest a new mechanism of cellular iron dysfunction through the E4BP4/G9a/SOSTDC1/hepcidin pathway, which is an essential link in TC.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	98-106
30141807-12	2018	Our results suggested that the intracellular iron reduction was due to the increase in the expression of ferroportin, an iron export protein in the stable cells overexpressing lipin1.	Iron	121-125	lipin 1	Homo sapiens	176-182
30141807-13	2018	In contrast, after transfection with lipin1 siRNA, the decreased expression of ferroportin contributed to an increase in the iron content in BEL7402 cells.	Iron	125-129	lipin 1	Homo sapiens	37-43
30141807-15	2018	Taken together, our findings demonstrate for the first time that lipin1 participates in the regulation of iron metabolism in human hepatic carcinoma cells.	Iron	106-110	lipin 1	Homo sapiens	65-71
30141807-16	2018	This suggests that lipin1 may play an important protective role in inhibiting the development of cancer through the reduction of iron content in tumors, which further demonstrates that iron reduction could be a potential strategy of cancer prevention and treatment.	Iron	129-133	lipin 1	Homo sapiens	19-25
30141807-16	2018	This suggests that lipin1 may play an important protective role in inhibiting the development of cancer through the reduction of iron content in tumors, which further demonstrates that iron reduction could be a potential strategy of cancer prevention and treatment.	Iron	185-189	lipin 1	Homo sapiens	19-25
29709961-2	2018	The loss of ferroxidase activity of ceruloplasmin due to gene mutations causes a disturbance in cellular iron transport.	Iron	105-109	ceruloplasmin	Homo sapiens	36-49
29529338-2	2018	Hepcidin promotes iron sequestration by macrophages: hepcidin concentration is reduced by anaemia and increased by inflammation.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
29529338-2	2018	Hepcidin promotes iron sequestration by macrophages: hepcidin concentration is reduced by anaemia and increased by inflammation.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	53-61
29777905-9	2018	Regarding mechanism, the "reprogramming" of polyamine metabolism by iron-depletion is consistent with the down-regulation of ADI1 and MAT2alpha, and the up-regulation of SAT1.	Iron	68-72	acireductone dioxygenase 1	Homo sapiens	125-129
29777905-10	2018	Moreover, changes in ADI1 (biosynthetic) and SAT1 (catabolic) partially depended on the iron-regulated changes in c-Myc and/or p53.	Iron	88-92	acireductone dioxygenase 1	Homo sapiens	21-25
29777905-10	2018	Moreover, changes in ADI1 (biosynthetic) and SAT1 (catabolic) partially depended on the iron-regulated changes in c-Myc and/or p53.	Iron	88-92	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	114-119
29775905-3	2018	Whereas bio-electrolysis reactor system (C-EL) Iron Scraps amended yield lesser methane (51.2 ml/g COD) in comparison to control bio-electrolysis reactor system without Iron scraps (C-CONT - 114.4 ml/g COD).	Iron	47-51	carboxyl ester lipase	Homo sapiens	41-45
29761622-4	2018	HMOX1 is a cytoprotective enzyme that degrades heme to generate carbon monoxide (CO), biliverdin, and molecular iron.	Iron	112-116	heme oxygenase 1	Homo sapiens	0-5
29696692-1	2018	Erythropoietin (Epo) drives iron (Fe) utilization for erythropoiesis, but the potentially resultant tissue iron deficiency (ID) can also impede brain development.	Iron	28-32	erythropoietin	Rattus norvegicus	0-14
29696692-1	2018	Erythropoietin (Epo) drives iron (Fe) utilization for erythropoiesis, but the potentially resultant tissue iron deficiency (ID) can also impede brain development.	Iron	28-32	erythropoietin	Rattus norvegicus	16-19
29696692-1	2018	Erythropoietin (Epo) drives iron (Fe) utilization for erythropoiesis, but the potentially resultant tissue iron deficiency (ID) can also impede brain development.	Iron	34-36	erythropoietin	Rattus norvegicus	0-14
29696692-1	2018	Erythropoietin (Epo) drives iron (Fe) utilization for erythropoiesis, but the potentially resultant tissue iron deficiency (ID) can also impede brain development.	Iron	34-36	erythropoietin	Rattus norvegicus	16-19
29696692-12	2018	Relative brain Fe (microg/g rat) was improved in the IS + Epo + Fe group.	Iron	15-17	erythropoietin	Rattus norvegicus	58-61
29696692-12	2018	Relative brain Fe (microg/g rat) was improved in the IS + Epo + Fe group.	Iron	64-66	erythropoietin	Rattus norvegicus	58-61
29696692-14	2018	Brain weight and brain Fe were related to plasma Epo levels.	Iron	23-25	erythropoietin	Rattus norvegicus	49-52
30354985-1	2018	Background and Purpose- Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate carbon monoxide, biliverdin, and iron.	Iron	125-129	heme oxygenase 1	Homo sapiens	24-40
30354985-1	2018	Background and Purpose- Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate carbon monoxide, biliverdin, and iron.	Iron	125-129	heme oxygenase 1	Homo sapiens	42-46
29800736-9	2018	Notably, the enhanced expression of TOR1 and TOR2 rescue the Torin2 augmented iron toxicity of yeast cell.	Iron	78-82	phosphatidylinositol kinase-related protein kinase TOR2	Saccharomyces cerevisiae S288C	45-49
30100261-0	2018	PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism.	Iron	83-87	PTEN induced putative kinase 1	Mus musculus	0-5
30100261-2	2018	Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism.	Iron	111-115	PTEN induced putative kinase 1	Mus musculus	26-31
30100261-4	2018	PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, which leads to the HIF1A-dependent Warburg effect and AIM2-dependent inflammasome activation in tumor cells.	Iron	90-94	PTEN induced putative kinase 1	Mus musculus	0-5
30100261-4	2018	PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, which leads to the HIF1A-dependent Warburg effect and AIM2-dependent inflammasome activation in tumor cells.	Iron	90-94	hypoxia inducible factor 1, alpha subunit	Mus musculus	128-133
30126153-1	2018	Bovine lactoferrin, extracted from milk or whey, is used in a range of products to enhance immunity and support digestive health, iron absorption, and homeostasis.	Iron	130-134	lactotransferrin	Bos taurus	7-18
29753693-2	2018	The aim of this study is to determine whether the combination of 5-aminolevulinic acid (ALA) and iron induces HO-1 expression in healthy human peripheral blood mononuclear cells (PBMC).	Iron	97-101	heme oxygenase 1	Homo sapiens	110-114
29753693-6	2018	Study C aimed to investigate HO-1 changes during a three-day, repetitive administration of ALA and iron.	Iron	99-103	heme oxygenase 1	Homo sapiens	29-33
30356966-0	2018	Fe-CoP Electrocatalyst Derived from a Bimetallic Prussian Blue Analogue for Large-Current-Density Oxygen Evolution and Overall Water Splitting.	Iron	0-2	caspase recruitment domain family member 16	Homo sapiens	3-6
29684424-13	2018	However, its importance to fly iron homeostasis is greatly minimized, which is instead dominated by another iron efflux avenue mediated by the ZIP13-ferritin axis along the ER/Golgi secretion pathway.	Iron	31-35	Ferritin 2 light chain homologue	Drosophila melanogaster	149-157
29684424-13	2018	However, its importance to fly iron homeostasis is greatly minimized, which is instead dominated by another iron efflux avenue mediated by the ZIP13-ferritin axis along the ER/Golgi secretion pathway.	Iron	108-112	Ferritin 2 light chain homologue	Drosophila melanogaster	149-157
29730778-8	2018	Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes.	Iron	48-50	adiponectin, C1Q and collagen domain containing	Mus musculus	248-259
29871715-9	2018	Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses.	Iron	54-58	solute carrier family 40 member 1	Homo sapiens	25-38
29871715-9	2018	Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses.	Iron	123-127	solute carrier family 40 member 1	Homo sapiens	25-38
29871715-9	2018	Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses.	Iron	123-127	solute carrier family 40 member 1	Homo sapiens	25-38
29871715-9	2018	Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses.	Iron	123-127	solute carrier family 40 member 1	Homo sapiens	25-38
30056060-1	2018	BACKGROUND: The contribution of hepcidin as a regulator of iron metabolism &amp; erythropoiesis on the severity of anemia in sickle cell disease (SCD) remains poorly characterized, especially in Sub-Saharan African populations.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	32-40
29157161-1	2018	OBJECTIVES: The inherited genetic disorder beta0-thalassemia/Hb E disease is associated with the over-suppression of the master regulator of iron homeostasis, the peptide hormone hepcidin.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	179-187
29667322-3	2018	We show that Fe deficiency-responsive genes were induced by Cd treatment, and that their upregulation was suppressed in bhlh104 loss-of-function mutants, but enhanced upon overexpression of bHLH104.	Iron	13-15	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	120-127
29667322-3	2018	We show that Fe deficiency-responsive genes were induced by Cd treatment, and that their upregulation was suppressed in bhlh104 loss-of-function mutants, but enhanced upon overexpression of bHLH104.	Iron	13-15	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	190-197
29939292-10	2018	Conversely, in the absence of gastric pH treatment, the iron uptake of native pea ferritin was unaffected by inhibitors of nonheme iron absorption, and the protein was observed to be internalized in Caco-2 cells.	Iron	56-60	ferritin-1, chloroplastic	Glycine max	82-90
29939292-13	2018	Conclusion: With consideration that nonheme dietary inhibitors display no effect on iron uptake and the low oxidative potential relative to FeSO4, intact pea ferritin appears to be a promising iron supplement.	Iron	193-197	ferritin-1, chloroplastic	Glycine max	158-166
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	39-43	Yap5p	Saccharomyces cerevisiae S288C	213-218
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	108-112	Yap5p	Saccharomyces cerevisiae S288C	213-218
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	108-112	Yap5p	Saccharomyces cerevisiae S288C	213-218
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	108-112	Yap5p	Saccharomyces cerevisiae S288C	213-218
29907852-8	2018	Cord Fe indicators were significantly associated with cord hepcidin, but not maternal hepcidin.	Iron	5-7	hepcidin antimicrobial peptide	Homo sapiens	59-67
30061540-7	2018	Finally, these studies show a significant increase in the relative biological effectiveness (RBE) of high LET SOBP carbon and iron ions in HR and PARP mutants.	Iron	126-130	poly [ADP-ribose] polymerase 1	Cricetulus griseus	146-150
29738311-7	2018	In particular, the alpha 1- and beta-BLBs intercalated by Mn or Fe atom can be transformed into a semiconductor, half metal or graphene-like semimetal.	Iron	64-66	adrenoceptor alpha 1D	Homo sapiens	19-26
30025536-0	2018	Correction to: Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer.	Iron	15-19	lactotransferrin	Bos taurus	51-62
30025536-0	2018	Correction to: Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer.	Iron	29-33	lactotransferrin	Bos taurus	51-62
29958803-7	2018	RNA-binding protein-mediated iron sensing may represent a simple yet effective means to adjust the inflammatory response to tissue homeostatic alterations.	Iron	29-33	RNA binding motif single stranded interacting protein 3	Homo sapiens	0-19
30002810-0	2018	Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington"s disease.	Iron	26-30	huntingtin	Mus musculus	7-17
29532452-0	2018	Hepcidin, an Iron Regulatory Hormone of Innate Immunity, is Differentially Expressed in Premature Fetuses with Early-Onset Neonatal Sepsis.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	0-8
29532452-1	2018	OBJECTIVE: Hepcidin, a mediator of innate immunity, binds the iron exporter ferroportin, leading to functional hypoferremia through intracellular iron sequestration.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	11-19
29532452-1	2018	OBJECTIVE: Hepcidin, a mediator of innate immunity, binds the iron exporter ferroportin, leading to functional hypoferremia through intracellular iron sequestration.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	11-19
29756187-5	2018	The establishment of acidic, unsaturated conditions in CT-CBP:s with low fractions (1 wt%) of binders increased the Cu release (to be higher than that from CT), owing to the dissolution of Cu-associated amorphous Fe precipitates.	Iron	213-215	sarcoplasmic calcium-binding protein	Drosophila melanogaster	58-61
29396964-3	2018	This study aims at assessing whether the ability of estrogen to downregulate hepcidin synthesis translates into changes in serum iron status.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	77-85
29396964-8	2018	In serum samples collected at random, estrogen (P=0.022; R=-0.213) and iron (P=0.028; R=-0.316) correlated negatively with hepcidin and positively with each other (P=0.033; R=0.319).	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	123-131
29417224-11	2018	Of interest, dietary iron restriction suppressed renal TGFbeta-RI expression and Smad2 phosphorylation in SHR-SP.	Iron	21-25	SMAD family member 2	Rattus norvegicus	81-86
29417224-12	2018	Furthermore, dietary iron restriction decreased renal fibrosis, renal MMP-2 and MMP-9 activities, renal TGFbeta-RI expression, and Smad2 phosphorylation in rats with unilateral ureteral obstruction.	Iron	21-25	SMAD family member 2	Rattus norvegicus	131-136
29594459-0	2018	Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	43-51
29594459-1	2018	Hepcidin is the key regulator of iron homeostasis in the body.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
29689452-0	2018	Role of the HSPA9/HSC20 chaperone pair in promoting directional human iron-sulfur cluster exchange involving monothiol glutaredoxin 5.	Iron	70-74	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	18-23
29689452-0	2018	Role of the HSPA9/HSC20 chaperone pair in promoting directional human iron-sulfur cluster exchange involving monothiol glutaredoxin 5.	Iron	70-74	glutaredoxin 5	Homo sapiens	109-133
29778670-1	2018	Iron is a component of many proteins that have crucial roles in plant growth and development, such as ferritin and catalase.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	102-110
29966042-1	2018	Herein, bimetallic iron (Fe)-manganese (Mn) oxyhydroxide ((Fe1-x, Mnx )OOH, FeMnOOH) nanosheets on fluorine-doped tin oxide conducting substrates and on semiconductor photoanodes are synthesized by a facile, room temperature, electroless deposition method as catalysts for both electrochemical and photo-electrochemical (PEC) water splitting, respectively.	Iron	19-23	keratin 86	Homo sapiens	66-69
30046590-7	2018	The R2 value was significantly increased in MSCs-FTH1 and Neurons-FTH1 cells, which was consistent with the findings of Prussian blue staining, transmission electron microscopy, and intracellular iron measurements.	Iron	196-200	ferritin heavy chain 1	Homo sapiens	49-53
30046590-7	2018	The R2 value was significantly increased in MSCs-FTH1 and Neurons-FTH1 cells, which was consistent with the findings of Prussian blue staining, transmission electron microscopy, and intracellular iron measurements.	Iron	196-200	ferritin heavy chain 1	Homo sapiens	66-70
29945649-6	2018	New evidence reports oral iron ingestion increases serum hepcidin leading to decreased absorption suggesting further decreasing efficacy.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	57-65
29872815-8	2018	The Fe overload increased the anti-inflammatory cytokines together with IL-1beta and IP-10.	Iron	4-6	interleukin-1 beta	Capra hircus	72-80
29921869-9	2018	Iron deposition associated with oxidative injury as indicated by heme oxygenase-1 abundance.	Iron	0-4	heme oxygenase 1	Homo sapiens	65-81
29790499-2	2018	Upon exposure to NO, the cluster undergoes a complex nitrosylation reaction resulting in a mixture of iron-nitrosyl species, which spectroscopic studies have indicated are similar to well characterized low molecular weight dinitrosyl iron complex (DNIC), Roussin"s Red Ester (RRE) and Roussin"s Black Salt (RBS).	Iron	102-106	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	285-305
29554518-9	2018	It has been demonstrated from the ultraviolet-visible spectral studies that the oxidation state of iron in cytochrome c does not change when the protein binds with the investigated surfactants.	Iron	99-103	cytochrome c, somatic	Equus caballus	107-119
30034931-4	2018	In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	49-57
30034931-4	2018	In systemic iron metabolism that is regulated by hepcidin-ferroportin axis, plasma iron is bound with transferrin (TF) which has two high-affinity binding sites for ferric iron.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	49-57
30034931-7	2018	TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells.	Iron	55-59	transferrin receptor 2	Homo sapiens	9-13
30034931-7	2018	TFR1 and TFR2 are two subtypes of TFRs those bind with iron-transferrin complex to facilitate iron into cells.	Iron	94-98	transferrin receptor 2	Homo sapiens	9-13
29404719-5	2018	In multivariate linear regression models, iron status was found to be associated with hepcidin levels in infants with wild-type HFE gene (p = 0.046 and p = 0.048 in 6- and 12-month-olds, respectively).	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	86-94
29404719-7	2018	Hepcidin levels increased in healthy infants during the first year of life and were positively associated with iron levels only in infants with wild-type HFE gene, a situation that requires further investigation.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	0-8
29453656-2	2018	In this review, we will briefly outline the general scheme of iron metabolism in humans and then focus our attention on the cellular iron export system formed by the permease ferroportin and the ferroxidase ceruloplasmin.	Iron	62-66	ceruloplasmin	Homo sapiens	207-220
29453656-2	2018	In this review, we will briefly outline the general scheme of iron metabolism in humans and then focus our attention on the cellular iron export system formed by the permease ferroportin and the ferroxidase ceruloplasmin.	Iron	133-137	ceruloplasmin	Homo sapiens	207-220
29453656-3	2018	We will finally summarize data on the role of the iron binding protein lactoferrin on the regulation of the ferroportin/ceruloplasmin couple and of other proteins involved in iron homeostasis in inflamed human macrophages.	Iron	50-54	ceruloplasmin	Homo sapiens	120-133
29464457-3	2018	The Lf receptor (LfR) plays an important role in absorption of Lf and Lf-bound iron by intestinal epithelial cells.	Iron	79-83	intelectin 1	Homo sapiens	4-15
29464457-3	2018	The Lf receptor (LfR) plays an important role in absorption of Lf and Lf-bound iron by intestinal epithelial cells.	Iron	79-83	intelectin 1	Homo sapiens	17-20
29516297-1	2018	Human and bovine lactoferrin (hLf and bLf) are multifunctional iron-binding glycoprotein constitutively synthesized and secreted by glandular epithelial cells and by neutrophils following induction.	Iron	63-67	lactotransferrin	Bos taurus	17-28
29516297-1	2018	Human and bovine lactoferrin (hLf and bLf) are multifunctional iron-binding glycoprotein constitutively synthesized and secreted by glandular epithelial cells and by neutrophils following induction.	Iron	63-67	HLF transcription factor, PAR bZIP family member	Homo sapiens	30-33
29627385-7	2018	The proteasome, E3 ubiquitin ligase Rsp5 and the Cdc48Npl4/Ufd1 complex are required for OLE1 activation during iron depletion.	Iron	112-116	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	36-40
29627385-7	2018	The proteasome, E3 ubiquitin ligase Rsp5 and the Cdc48Npl4/Ufd1 complex are required for OLE1 activation during iron depletion.	Iron	112-116	nuclear protein localization protein 4	Saccharomyces cerevisiae S288C	49-58
29627385-7	2018	The proteasome, E3 ubiquitin ligase Rsp5 and the Cdc48Npl4/Ufd1 complex are required for OLE1 activation during iron depletion.	Iron	112-116	polyubiquitin-binding protein UFD1	Saccharomyces cerevisiae S288C	59-63
29501406-13	2018	BOLA3 appears to play a critical role in the electron transport system and production of iron-sulfur clusters that are related to lipid metabolism and enzyme biosynthesis.	Iron	89-93	bolA family member 3	Homo sapiens	0-5
29517550-1	2018	OBJECTIVE: Because anemia of inflammation is common in ICU patients and hepcidin is the key regulator of iron homeostasis, we examined time-dependent changes in hepcidin, erythropoietin, iron, and inflammatory markers in surgical ICU patients with anemia.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	72-80
29517550-8	2018	Hepcidin was positively correlated with RBC transfusion, C-reactive protein, interleukin-6, ferritin, and negatively correlated with iron, total iron binding capacity, transferrin, and reticulocyte response.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	0-8
29517550-8	2018	Hepcidin was positively correlated with RBC transfusion, C-reactive protein, interleukin-6, ferritin, and negatively correlated with iron, total iron binding capacity, transferrin, and reticulocyte response.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	0-8
29772541-2	2018	Heme oxygenase-1 (HO-1), a microsomal enzyme discovered decades ago, can metabolize pro-oxidant heme into biliverdin, free iron, and carbon monoxide.	Iron	123-127	heme oxygenase 1	Homo sapiens	0-16
29772541-2	2018	Heme oxygenase-1 (HO-1), a microsomal enzyme discovered decades ago, can metabolize pro-oxidant heme into biliverdin, free iron, and carbon monoxide.	Iron	123-127	heme oxygenase 1	Homo sapiens	18-22
29575577-7	2018	We found that Smad6 and Bambi-but not Follistatin-are controlled by the iron-BMP-Smad pathway.	Iron	72-76	SMAD family member 6	Mus musculus	14-19
29575577-7	2018	We found that Smad6 and Bambi-but not Follistatin-are controlled by the iron-BMP-Smad pathway.	Iron	72-76	SMAD family member 1	Mus musculus	14-18
29544765-1	2018	PURPOSE: The heavy subunit of the iron storage protein ferritin (FHC) is essential for the intracellular iron metabolism and, at the same time, it represents a central hub of iron-independent pathways, such as cell proliferation, angiogenesis, p53 regulation, chemokine signalling, stem cell expansion, miRNAs expression.	Iron	34-38	low density lipoprotein receptor	Homo sapiens	65-68
29544765-1	2018	PURPOSE: The heavy subunit of the iron storage protein ferritin (FHC) is essential for the intracellular iron metabolism and, at the same time, it represents a central hub of iron-independent pathways, such as cell proliferation, angiogenesis, p53 regulation, chemokine signalling, stem cell expansion, miRNAs expression.	Iron	105-109	low density lipoprotein receptor	Homo sapiens	65-68
29544765-1	2018	PURPOSE: The heavy subunit of the iron storage protein ferritin (FHC) is essential for the intracellular iron metabolism and, at the same time, it represents a central hub of iron-independent pathways, such as cell proliferation, angiogenesis, p53 regulation, chemokine signalling, stem cell expansion, miRNAs expression.	Iron	105-109	low density lipoprotein receptor	Homo sapiens	65-68
29899851-7	2018	Knockdown of hepcidin antimicrobial peptide led to enhanced heavy chain of ferritin expression in human hepatocytes, indicating association between hepcidin production and iron storage in hepatocytes.	Iron	172-176	hepcidin antimicrobial peptide	Homo sapiens	13-21
29764842-4	2018	Hepcidin regulation in hepatocytes is well characterized and mostly dependent on interleukin-6 signaling during inflammation, although in myeloid cells, hepcidin induction and the mechanisms leading to intracellular iron regulation remain elusive.	Iron	216-220	hepcidin antimicrobial peptide	Homo sapiens	0-8
29764842-6	2018	By measuring the transcriptional levels of iron-related proteins (eg, hepcidin, ferroportin, and ferritin), we observed that TLR signaling can induce intracellular iron sequestration in macrophages through 2 independent but redundant mechanisms.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	70-78
29764842-8	2018	Infection with Mycobacterium bovis Bacillus Calmette-Guerin promotes intracellular iron sequestration through both hepcidin upregulation and ferroportin downregulation.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	115-123
29784770-1	2018	Given the essential roles of iron-sulfur (Fe-S) cofactors in mediating electron transfer in the mitochondrial respiratory chain and supporting heme biosynthesis, mitochondrial dysfunction is a common feature in a growing list of human Fe-S cluster biogenesis disorders, including Friedreich ataxia and GLRX5-related sideroblastic anemia.	Iron	42-46	glutaredoxin 5	Homo sapiens	302-307
29784770-2	2018	Here, our studies showed that restriction of Fe-S cluster biogenesis not only compromised mitochondrial oxidative metabolism but also resulted in decreased overall histone acetylation and increased H3K9me3 levels in the nucleus and increased acetylation of alpha-tubulin in the cytosol by decreasing the lipoylation of the pyruvate dehydrogenase complex, decreasing levels of succinate dehydrogenase and the histone acetyltransferase ELP3, and increasing levels of the tubulin acetyltransferase MEC17.	Iron	45-49	alpha tubulin acetyltransferase 1	Homo sapiens	495-500
29872401-7	2018	The correlation analysis indicated that the decreased hepcidin may have contributed to enhanced iron availability in HAPC, and decreased interleukin (IL)-10 and IL-22 were significantly associated with decreased hepcidin.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	54-62
29872401-8	2018	The results of the animal experiments confirmed that a certain degree of iron redundancy may promote bone marrow erythropoiesis and peripheral red blood cell production in hypoxic mice and that decreased IL-10 and IL-22 stimulated iron mobilization during hypoxia by affecting hepcidin expression.	Iron	231-235	interleukin 22	Mus musculus	214-219
29888000-1	2018	Studies had shown that iron-cycling was disturbed by inflammatory process through the role of hepcidin.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	94-102
29396846-10	2018	Finally, we described a patient showing marked iron overload due to the coinheritance of PIEZO1 and SEC23B mutations, demonstrating that the multi-gene approach is valuable not only for achieving a correct and definitive diagnosis, but also for guiding treatment.	Iron	47-51	piezo type mechanosensitive ion channel component 1	Homo sapiens	89-95
29396846-10	2018	Finally, we described a patient showing marked iron overload due to the coinheritance of PIEZO1 and SEC23B mutations, demonstrating that the multi-gene approach is valuable not only for achieving a correct and definitive diagnosis, but also for guiding treatment.	Iron	47-51	SEC23 homolog B, COPII coat complex component	Homo sapiens	100-106
29373036-3	2018	Whereas WT mice with iron overload developed diastolic dysfunction, iron-overloaded Timp3-/- mice showed worsened cardiac dysfunction coupled with systolic dysfunction.	Iron	68-72	tissue inhibitor of metalloproteinase 3	Mus musculus	84-89
29373036-5	2018	Iron overload in Timp3-/- mice showed twofold higher iron accumulation in the liver compared with WT mice because of constituently lower levels of ferroportin.	Iron	0-4	tissue inhibitor of metalloproteinase 3	Mus musculus	17-22
29373036-5	2018	Iron overload in Timp3-/- mice showed twofold higher iron accumulation in the liver compared with WT mice because of constituently lower levels of ferroportin.	Iron	53-57	tissue inhibitor of metalloproteinase 3	Mus musculus	17-22
29373036-6	2018	Loss of Timp3 enhanced the hepatic inflammatory response to iron overload, leading to greater neutrophil and macrophage infiltration and increased hepatic fibrosis.	Iron	60-64	tissue inhibitor of metalloproteinase 3	Mus musculus	8-13
29373036-7	2018	Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1beta and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3-/- livers.	Iron	173-177	tissue inhibitor of metalloproteinase 3	Mus musculus	189-194
29373036-9	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated heart and liver injury, suggesting that Timp3 is a key protective molecule against iron-mediated pathology.	Iron	45-49	tissue inhibitor of metalloproteinase 3	Mus musculus	108-113
29373036-9	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated heart and liver injury, suggesting that Timp3 is a key protective molecule against iron-mediated pathology.	Iron	151-155	tissue inhibitor of metalloproteinase 3	Mus musculus	8-13
29373036-9	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated heart and liver injury, suggesting that Timp3 is a key protective molecule against iron-mediated pathology.	Iron	151-155	tissue inhibitor of metalloproteinase 3	Mus musculus	108-113
29373036-10	2018	NEW &amp; NOTEWORTHY In mice, loss of tissue inhibitor of metalloproteinase 3 ( Timp3) was associated with systolic and diastolic dysfunctions, twofold higher hepatic iron accumulation (attributable to constituently lower levels of ferroportin), and increased hepatic inflammation.	Iron	167-171	tissue inhibitor of metalloproteinase 3	Mus musculus	38-77
29373036-10	2018	NEW &amp; NOTEWORTHY In mice, loss of tissue inhibitor of metalloproteinase 3 ( Timp3) was associated with systolic and diastolic dysfunctions, twofold higher hepatic iron accumulation (attributable to constituently lower levels of ferroportin), and increased hepatic inflammation.	Iron	167-171	tissue inhibitor of metalloproteinase 3	Mus musculus	80-85
29373036-11	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated injury, suggesting that Timp3 plays a key protective role against iron-mediated pathology.	Iron	45-49	tissue inhibitor of metalloproteinase 3	Mus musculus	8-13
29373036-11	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated injury, suggesting that Timp3 plays a key protective role against iron-mediated pathology.	Iron	45-49	tissue inhibitor of metalloproteinase 3	Mus musculus	92-97
29373036-11	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated injury, suggesting that Timp3 plays a key protective role against iron-mediated pathology.	Iron	134-138	tissue inhibitor of metalloproteinase 3	Mus musculus	8-13
29373036-11	2018	Loss of Timp3 enhanced the susceptibility to iron overload-mediated injury, suggesting that Timp3 plays a key protective role against iron-mediated pathology.	Iron	134-138	tissue inhibitor of metalloproteinase 3	Mus musculus	92-97
29659799-0	2018	Exposure of Escherichia coli to human hepcidin results in differential expression of genes associated with iron homeostasis and oxidative stress.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	38-46
29659799-3	2018	Using the Miller assay it was determined that under low iron availability exposure to sub-inhibitory doses of hepcidin (4-12muM) led to 2-fold and 4-fold increases in the expression of ftnA and bfd, respectively (P &lt; 0.05), in both a wild type (WT) and Deltafur (ferric uptake regulator) background.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	110-118
29371322-0	2018	Iron overload in transfusion-dependent survivors of hemoglobin Bart"s hydrops fetalis.	Iron	0-4	ADP ribosylation factor like GTPase 2 binding protein	Homo sapiens	63-67
29452354-5	2018	We discovered that alpha-syn expression phenocopies the high iron condition: under the low iron condition (<1 microM), alpha-syn inhibits Snx3-retromer-mediated recycling of Fet3/Ftr1 and instead shunts Fet3/Ftr1 into the multivesicular body pathway to the vacuole.	Iron	91-95	synuclein alpha	Homo sapiens	119-128
29452354-5	2018	We discovered that alpha-syn expression phenocopies the high iron condition: under the low iron condition (<1 microM), alpha-syn inhibits Snx3-retromer-mediated recycling of Fet3/Ftr1 and instead shunts Fet3/Ftr1 into the multivesicular body pathway to the vacuole.	Iron	91-95	sorting nexin 3	Homo sapiens	138-142
29452354-7	2018	In C. elegans, transgenic worms expressing alpha-syn exhibit an age-dependent degeneration of dopaminergic neurons that is partially rescued by the iron chelator desferoxamine.	Iron	148-152	synuclein alpha	Homo sapiens	43-52
29452354-8	2018	This implies that alpha-syn-expressing dopaminergic neurons are susceptible to changes in iron neurotoxicity with age, whereby excess iron enhances alpha-syn-induced neurodegeneration.	Iron	90-94	synuclein alpha	Homo sapiens	18-27
29452354-8	2018	This implies that alpha-syn-expressing dopaminergic neurons are susceptible to changes in iron neurotoxicity with age, whereby excess iron enhances alpha-syn-induced neurodegeneration.	Iron	134-138	synuclein alpha	Homo sapiens	18-27
29452354-8	2018	This implies that alpha-syn-expressing dopaminergic neurons are susceptible to changes in iron neurotoxicity with age, whereby excess iron enhances alpha-syn-induced neurodegeneration.	Iron	134-138	synuclein alpha	Homo sapiens	148-157
29452354-9	2018	In vivo genetic analysis indicates that alpha-syn dysregulates iron homeostasis in worm dopaminergic neurons, possibly by inhibiting SNX-3-mediated recycling of a membrane-bound ortholog of Cp (F21D5.3), the iron exporter ferroportin (FPN1.1), or both.	Iron	63-67	synuclein alpha	Homo sapiens	40-49
29452354-9	2018	In vivo genetic analysis indicates that alpha-syn dysregulates iron homeostasis in worm dopaminergic neurons, possibly by inhibiting SNX-3-mediated recycling of a membrane-bound ortholog of Cp (F21D5.3), the iron exporter ferroportin (FPN1.1), or both.	Iron	208-212	synuclein alpha	Homo sapiens	40-49
29452354-9	2018	In vivo genetic analysis indicates that alpha-syn dysregulates iron homeostasis in worm dopaminergic neurons, possibly by inhibiting SNX-3-mediated recycling of a membrane-bound ortholog of Cp (F21D5.3), the iron exporter ferroportin (FPN1.1), or both.	Iron	208-212	ceruloplasmin	Homo sapiens	190-192
29407213-2	2018	Since BMP plays a role in intracellular iron homeostasis via the hepcidin/ferroportin axis, and iron is required for myelination, this study was aimed to determine whether noggin affected iron status and remyelination in the brain following ischemic stroke.	Iron	40-44	bone morphogenetic protein 1	Homo sapiens	6-9
29407213-9	2018	We suggest that the BMP/hepcidin pathway can be a target for the regulation of the iron status in microglia to enhance remyelination in the ischemic brain.	Iron	83-87	bone morphogenetic protein 1	Homo sapiens	20-23
29407213-9	2018	We suggest that the BMP/hepcidin pathway can be a target for the regulation of the iron status in microglia to enhance remyelination in the ischemic brain.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	24-32
29731920-0	2018	Association of iron metabolic enzyme hepcidin expression levels with the prognosis of patients with pancreatic cancer.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	37-45
29731920-1	2018	Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
29731920-4	2018	Hepcidin, which is a peptide hormone mainly generated by the liver, inhibits iron absorption via enterocytes and iron release from macrophages.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
29731920-4	2018	Hepcidin, which is a peptide hormone mainly generated by the liver, inhibits iron absorption via enterocytes and iron release from macrophages.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	0-8
29731920-5	2018	Notably, hepcidin regulates iron homeostasis in the body by regulating the iron transporter ferroportin.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	9-17
29695288-0	2018	Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading.	Iron	67-71	bone morphogenetic protein 6	Mus musculus	16-44
29695288-2	2018	Since the identification of iron overload in the bone morphogenetic protein 6 (Bmp6) knockout mouse, the search has been on for clinically pathogenic variants in the BMP6 gene.	Iron	28-32	bone morphogenetic protein 6	Mus musculus	49-77
29695288-3	2018	A recent report proposes that variants in the pro-peptide region of BMP6 are the underlying cause of several cases of iron overload.	Iron	118-122	bone morphogenetic protein 6	Mus musculus	68-72
29695288-4	2018	We performed targeted next-generation sequencing on three cases of atypical iron overload with Asian ethnicity and identified a p.Q118dup (aka p.E112indelEQ, p.Q115dup, p.Q118_L119insQ) variant in BMP6.	Iron	76-80	bone morphogenetic protein 6	Mus musculus	197-201
29695288-8	2018	CONCLUSIONS: Our data suggest that assignment of disease causation in clinical cases of iron overload to pro-peptide variants in BMP6 should thus be treated with caution and requires biological characterization.	Iron	88-92	bone morphogenetic protein 6	Mus musculus	129-133
29611701-5	2018	Also, Fe,Co,N-CNP(0.3) presents comparable ORR catalytic activity as Pt/C in the acidic electrolyte with E1/2 of 0.764 V and superior methanol tolerance and electrochemical stability.	Iron	6-8	small nucleolar RNA, H/ACA box 73A	Homo sapiens	105-114
29195219-0	2018	Nanoconjugates of ferrocene and carbon-encapsulated iron nanoparticles as sensing platforms for voltammetric determination of ceruloplasmin in blood.	Iron	52-56	ceruloplasmin	Homo sapiens	126-139
29019009-7	2018	The released FTH1 appears in the form of an oligomer with a molecular mass of approximately 480 kDa, which is able to bind iron.	Iron	123-127	ferritin heavy chain 1	Homo sapiens	13-17
29383642-2	2018	In this paper, the iron doped fibrous-structured silica (KCC-1) nanospheres (Fe-KCC-1) was prepared, characterized, and applied as a catalyst for catalytic ozonation of sulfamethazine (SMT).	Iron	19-23	solute carrier family 12 member 4	Homo sapiens	57-62
29383642-2	2018	In this paper, the iron doped fibrous-structured silica (KCC-1) nanospheres (Fe-KCC-1) was prepared, characterized, and applied as a catalyst for catalytic ozonation of sulfamethazine (SMT).	Iron	19-23	solute carrier family 12 member 4	Homo sapiens	80-85
29383642-4	2018	The experimental results showed that Fe-KCC-1 had large surface area (464.56 m2 g-1) and iron particles were well dispersed on the catalyst.	Iron	89-93	solute carrier family 12 member 4	Homo sapiens	40-45
29383642-6	2018	With addition of Fe-KCC-1, the ozone utilization increased nearly two times than single ozonation.	Iron	17-19	solute carrier family 12 member 4	Homo sapiens	20-25
29282766-1	2018	OBJECTIVES: To investigate the link between serum erythroferrone (ERFE) levels and iron status parameters in pediatric patients with iron deficiency anemia.	Iron	83-87	erythroferrone	Homo sapiens	66-70
29579916-5	2018	The results of the studies included in this review indicate that LF stability is dependent on its level of iron-saturation and on the characteristics of the treatment media.	Iron	107-111	lactotransferrin	Bos taurus	65-67
29373688-6	2018	Main Outcome Measure(s): We measured the activity of Jumonji domain containing protein 6 (JMJD6), a ferrous iron (Fe2+)- and oxygen-dependent histone demethylase, and examined its function in the epigenetic control of VHL.	Iron	108-112	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	90-95
29441715-2	2018	At the cell surface of hepatocytes, TMPRSS6 cleaves haemojuvelin (HJV) and regulates the BMP/SMAD signalling pathway leading to production of hepcidin, a key regulator of iron absorption.	Iron	171-175	hemojuvelin BMP co-receptor	Homo sapiens	66-69
29441715-2	2018	At the cell surface of hepatocytes, TMPRSS6 cleaves haemojuvelin (HJV) and regulates the BMP/SMAD signalling pathway leading to production of hepcidin, a key regulator of iron absorption.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	142-150
29364516-0	2018	Iron promotes alpha-synuclein aggregation and transmission by inhibiting TFEB-mediated autophagosome-lysosome fusion.	Iron	0-4	synuclein, alpha	Mus musculus	14-29
29364516-4	2018	However, whether iron is a cofactor in facilitating the spread of alpha-synuclein remains unclear.	Iron	17-21	synuclein, alpha	Mus musculus	66-81
29364516-8	2018	Our results demonstrated that iron promoted alpha-synuclein aggregation and transmission by inhibiting autophagosome-lysosome fusion.	Iron	30-34	synuclein, alpha	Mus musculus	44-59
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	synuclein, alpha	Mus musculus	202-217
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	synuclein, alpha	Mus musculus	202-217
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	synuclein, alpha	Mus musculus	202-217
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	synuclein, alpha	Mus musculus	202-217
29364516-11	2018	Taken together, our data reveal a previously unknown relationship between iron and alpha-synuclein, and identify TFEB as not only a potential target for preventing alpha-synuclein transmission, but also a critical factor for iron-induced alpha-synuclein aggregation and transmission.	Iron	74-78	synuclein, alpha	Mus musculus	83-98
29364516-12	2018	Indeed, this newly discovered role of iron and TFEB in synucleinopathies may provide novel targets for developing therapeutic strategies to prevent alpha-synuclein transmission in Parkinson"s disease.	Iron	38-42	synuclein, alpha	Mus musculus	148-163
28130911-0	2018	Relationship of serum haemojuvelin and hepcidin levels with iron level and erythropoietin requirement in prevalent hepatitis C virus positive haemodialysis patients.	Iron	60-64	hemojuvelin BMP co-receptor	Homo sapiens	22-34
28130911-0	2018	Relationship of serum haemojuvelin and hepcidin levels with iron level and erythropoietin requirement in prevalent hepatitis C virus positive haemodialysis patients.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	39-47
28130911-2	2018	Soluble haemojuvelin (sHJV) has recently emerged as one of the significant regulators of iron homeostasis and hepcidin expression.	Iron	89-93	hemojuvelin BMP co-receptor	Homo sapiens	8-20
28130911-10	2018	CONCLUSION: Soluble haemojuvelin levels seem to be associated with iron overload parameters and hepcidin levels in HCV positive HD patients.	Iron	67-71	hemojuvelin BMP co-receptor	Homo sapiens	20-32
29295890-6	2018	Conversely, miR-7-5p and miR-141-3p antagomiRs partially but significantly blocked iron- or IRP knockdown-induced down-regulation of TfR1 mRNA, suggesting the interplay between these microRNAs and IRPs along with involvement of another uncharacterized mechanism in TfR1 mRNA degradation.	Iron	83-87	microRNA 7-3	Homo sapiens	12-20
29616062-7	2018	Thus, FCR activity and expression of Fe-deficiency response genes, especially CsFRO1 and CsHA1, preceded the trend of SPAD index and acted as indicators of whether the plant was sensing or not metabolically active Fe due to the treatments.	Iron	37-39	plasma membrane ATPase 4	Cucumis sativus	89-94
29547723-7	2018	Thus, IRT1 directly senses elevated non-iron metal concentrations and integrates multiple substrate-dependent regulations to optimize iron uptake and protect plants from highly reactive metals.	Iron	134-138	allograft inflammatory factor 1	Homo sapiens	6-10
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	30-34	transferrin receptor 2	Homo sapiens	0-4
29388418-5	2018	TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron saturation of Tf is high.	Iron	69-73	transferrin receptor 2	Homo sapiens	0-4
28762519-7	2018	We further detected increased levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1 + IRE) in IA testes, whereas the increasing trend of iron exporter ferroportin 1 (FPN1) was not statistically significant.	Iron	40-44	doublesex and mab-3 related transcription factor 1	Homo sapiens	113-117
29032941-8	2018	Excess iron uptake during differentiation triggered lysosomal degradation of NCOA4, which was dependent on the E3 ubiquitin ligase HERC2.	Iron	7-11	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Mus musculus	131-136
29309586-0	2018	Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.	Iron	35-39	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	10-15
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	60-64	cytosolic iron-sulfur assembly component 2B	Homo sapiens	120-126
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	cytosolic iron-sulfur assembly component 2B	Homo sapiens	120-126
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	cytosolic iron-sulfur assembly component 2B	Homo sapiens	120-126
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	cytosolic iron-sulfur assembly component 2B	Homo sapiens	120-126
29309586-4	2018	Here, we investigated the potential role of the human cochaperone HSC20 in cytosolic Fe-S assembly and found that HSC20 assists Fe-S cluster delivery to cytosolic and nuclear Fe-S proteins.	Iron	85-89	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	66-71
29309586-4	2018	Here, we investigated the potential role of the human cochaperone HSC20 in cytosolic Fe-S assembly and found that HSC20 assists Fe-S cluster delivery to cytosolic and nuclear Fe-S proteins.	Iron	85-89	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	114-119
29309586-4	2018	Here, we investigated the potential role of the human cochaperone HSC20 in cytosolic Fe-S assembly and found that HSC20 assists Fe-S cluster delivery to cytosolic and nuclear Fe-S proteins.	Iron	128-132	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	66-71
29309586-4	2018	Here, we investigated the potential role of the human cochaperone HSC20 in cytosolic Fe-S assembly and found that HSC20 assists Fe-S cluster delivery to cytosolic and nuclear Fe-S proteins.	Iron	128-132	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	114-119
29309586-4	2018	Here, we investigated the potential role of the human cochaperone HSC20 in cytosolic Fe-S assembly and found that HSC20 assists Fe-S cluster delivery to cytosolic and nuclear Fe-S proteins.	Iron	128-132	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	66-71
29309586-4	2018	Here, we investigated the potential role of the human cochaperone HSC20 in cytosolic Fe-S assembly and found that HSC20 assists Fe-S cluster delivery to cytosolic and nuclear Fe-S proteins.	Iron	128-132	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	114-119
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	89-93	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	10-15
29309586-5	2018	Cytosolic HSC20 (C-HSC20) mediated complex formation between components of the cytosolic Fe-S biogenesis pathway (ISC), including the primary scaffold, ISCU1, and the cysteine desulfurase, NFS1, and the CIA targeting complex, consisting of CIAO1, FAM96B and MMS19, to facilitate Fe-S cluster insertion into cytoplasmic and nuclear Fe-S recipients.	Iron	89-93	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	19-24
29264659-1	2018	Human glutaredoxin 5 (Grx5) is one of the core components of the Isc (iron-sulfur cluster) assembly and trafficking machinery, and serves as an intermediary cluster carrier, putatively delivering cluster from the Isu scaffold protein to target proteins.	Iron	70-74	glutaredoxin 5	Homo sapiens	6-20
29264659-1	2018	Human glutaredoxin 5 (Grx5) is one of the core components of the Isc (iron-sulfur cluster) assembly and trafficking machinery, and serves as an intermediary cluster carrier, putatively delivering cluster from the Isu scaffold protein to target proteins.	Iron	70-74	glutaredoxin 5	Homo sapiens	22-26
29264659-2	2018	The tripeptide glutathione is intimately involved in this role, providing cysteinyl coordination to the iron center of the Grx5-bound [2Fe-2S] cluster.	Iron	104-108	glutaredoxin 5	Homo sapiens	123-127
29055896-0	2018	SIFD as a novel cause of severe fetal hydrops and neonatal anaemia with iron loading and marked extramedullary haemopoiesis.	Iron	72-76	tRNA nucleotidyl transferase 1	Homo sapiens	0-4
29782267-1	2018	BACKGROUND: Literature data on hepcidin (H) level - the main regulator of systemic iron homeostasis in patients with chronic heart failure (CHF) - are contradictory.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	31-39
29424844-7	2018	Increasing brain iron with TMHF accelerated plaque formation, increased Abeta staining, and increased senile morphology of amyloid plaques.	Iron	17-21	amyloid beta (A4) precursor protein	Mus musculus	72-77
29334423-1	2018	Mechanochemical activation of iron cyano complexes by ball milling results in the formation of HCN, which can be trapped and incorporated into alpha-aminonitriles.	Iron	30-34	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	95-98
29368506-1	2018	Apoferritin (AF) is a natural nontoxic iron carrier and has a natural hollow structure that can be used to deliver small molecules.	Iron	39-43	ferritin heavy chain 1	Homo sapiens	0-11
20301523-0	1993	TFR2-Related Hereditary Hemochromatosis CLINICAL CHARACTERISTICS: TFR2-related hereditary hemochromatosis (TFR2-HHC) is characterized by increased intestinal iron absorption resulting in iron accumulation in the liver, heart, pancreas, and endocrine organs.	Iron	158-162	transferrin receptor 2	Homo sapiens	0-4
20301523-0	1993	TFR2-Related Hereditary Hemochromatosis CLINICAL CHARACTERISTICS: TFR2-related hereditary hemochromatosis (TFR2-HHC) is characterized by increased intestinal iron absorption resulting in iron accumulation in the liver, heart, pancreas, and endocrine organs.	Iron	187-191	transferrin receptor 2	Homo sapiens	0-4
29372726-4	2018	Importantly, Fe atoms are pivotal in the electron transport of FeB2-based devices.	Iron	13-15	FEB2	Homo sapiens	63-67
29415739-0	2018	Hepcidin, an emerging and important player in brain iron homeostasis.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
29415739-1	2018	Hepcidin is emerging as a new important factor in brain iron homeostasis.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
29415739-3	2018	Little is known about the molecular mediators of local hepcidin expression, but inflammation and iron-load have been shown to induce hepcidin expression in the brain.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	133-141
29415739-5	2018	Role of hepcidin in brain functions has been observed during neuronal iron-load and brain hemorrhage, where secretion of abundant hepcidin is related with the severity of brain damage.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	8-16
29415739-7	2018	Studies have yet to unveil its role in other brain conditions, but the rationale exists, since these conditions are characterized by overexpression of the factors that stimulate brain hepcidin expression, such as inflammation, hypoxia and iron-overload.	Iron	239-243	hepcidin antimicrobial peptide	Homo sapiens	184-192
29394034-7	2018	Furthermore, Fe-binding and Fe-regulatory proteins, such as hepcidin, lipocalin-2/NGAL, heme oxygenase-1, ferritin, and iron-sulfur clusters can display antitumor properties under specific conditions and in particular cancer types.	Iron	13-15	hepcidin antimicrobial peptide	Homo sapiens	60-68
29394034-7	2018	Furthermore, Fe-binding and Fe-regulatory proteins, such as hepcidin, lipocalin-2/NGAL, heme oxygenase-1, ferritin, and iron-sulfur clusters can display antitumor properties under specific conditions and in particular cancer types.	Iron	13-15	heme oxygenase 1	Homo sapiens	88-104
29399718-5	2018	In another observation, the high sensitivity of the HCN molecule for the Fe-incorporated ZnO nanotube suggests it as a potential gas sensor.	Iron	73-75	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	52-55
29339674-3	2018	Hepcidin is an important hormone in iron metabolism.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
29285662-1	2018	Lactoferrin (Lf) and transferrin (Tf) are iron-binding proteins that can bind various metal ions.	Iron	42-46	lactotransferrin	Bos taurus	0-11
29285662-1	2018	Lactoferrin (Lf) and transferrin (Tf) are iron-binding proteins that can bind various metal ions.	Iron	42-46	lactotransferrin	Bos taurus	13-15
29061364-0	2018	Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.	Iron	42-46	presenilin 1	Mus musculus	89-92
29434729-6	2018	There were marked abnormalities in iron regulation gene expression between the AA and composite model groups, as seen by the significant decrease of hepcidin expression in the liver (P&lt;0.01) that paralleled the changes in BMP6, SMAD4, and TfR2.	Iron	35-39	bone morphogenetic protein 6	Mus musculus	225-229
28412770-3	2018	Hepcidin-mediated iron restriction also contributes to anemia by downregulating both intestinal iron absorption and release of stored iron for erythropoiesis.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
28412770-3	2018	Hepcidin-mediated iron restriction also contributes to anemia by downregulating both intestinal iron absorption and release of stored iron for erythropoiesis.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	0-8
28412770-3	2018	Hepcidin-mediated iron restriction also contributes to anemia by downregulating both intestinal iron absorption and release of stored iron for erythropoiesis.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	0-8
29386206-14	2018	CONCLUSIONS: Targeting iron-induced overexpression of NCBE may be a translatable therapeutic strategy for the treatment of PHH following GMH.	Iron	23-27	solute carrier family 4 member 10	Rattus norvegicus	54-58
29390824-5	2018	Additionally, using 16 transition metal (Fe and Co) complexes, we show that low-spin states are stabilised by increasing contributions from MP2 within the double hybrid formulation.	Iron	41-43	tryptase pseudogene 1	Homo sapiens	140-143
29373985-9	2018	CONCLUSIONS: This rare case of a patient with juvenile hemochromatosis associated with a HJV mutation provides histologic evidence documenting the reversal of associated end-stage heart failure, requiring emergent mechanical circulatory support, with iron chelation therapy.	Iron	251-255	hemojuvelin BMP co-receptor	Homo sapiens	89-92
29399365-4	2018	Hepcidin-25 is an antimicrobial peptide that sequesters iron intracellularly, and its elevation following human ischemia reperfusion injury may represent a renoprotective response to minimize renal injury.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
29260183-7	2018	The inhibition of DMT1/Nramp2 and siRNA knockdown of Nramp1 each reduced the transfer of 59Fe from lysosomes to the cytosol; and hepatocyte-specific knockout of DMT1 in mice prevented the release of Fe from the liver responding to EPO treatment, but did not inhibit lysosomal ferritin degradation.	Iron	91-93	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	53-59
29473051-6	2018	Conclusions: Our results suggest that AP4M1 represents a new candidate gene that should be considered in the neurodegeneration with brain iron accumulation (NBIA) spectrum of disorders and highlight the intersections between hereditary spastic paraplegia and NBIA clinical presentations.	Iron	138-142	adaptor related protein complex 4 subunit mu 1	Homo sapiens	38-43
29330517-0	2018	Iron-induced calcification in human aortic vascular smooth muscle cells through interleukin-24 (IL-24), with/without TNF-alpha.	Iron	0-4	interleukin 24	Homo sapiens	80-94
29330517-0	2018	Iron-induced calcification in human aortic vascular smooth muscle cells through interleukin-24 (IL-24), with/without TNF-alpha.	Iron	0-4	interleukin 24	Homo sapiens	96-101
29211945-0	2018	Regulation of human Nfu activity in Fe-S cluster delivery-characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex.	Iron	36-40	NFU1 iron-sulfur cluster scaffold	Homo sapiens	20-23
29211945-8	2018	Additionally, the chaperone complex was able to promote Nfu function by enhancing the second-order rate constants for Fe-S cluster transfer to target proteins and providing directionality in cluster transfer from Nfu by eliminating promiscuous transfer reactions.	Iron	118-122	NFU1 iron-sulfur cluster scaffold	Homo sapiens	56-59
29211945-9	2018	Together, these data support a hypothesis in which Nfu can serve as an alternative carrier protein for chaperone-mediated cluster release and delivery in Fe-S cluster biogenesis and trafficking.	Iron	154-158	NFU1 iron-sulfur cluster scaffold	Homo sapiens	51-54
28859237-0	2018	Cystathionine beta-synthase is required for body iron homeostasis.	Iron	49-53	cystathionine beta-synthase	Mus musculus	0-27
28859237-2	2018	In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis.	Iron	209-213	cystathionine beta-synthase	Mus musculus	48-51
28859237-2	2018	In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis.	Iron	209-213	cystathionine beta-synthase	Mus musculus	185-188
28859237-3	2018	We found that CBS knockout (CBS-/- ) mice exhibited anemia and a significant increase in iron content in the serum, liver, spleen, and heart, along with severe damage to the liver, displaying a hemochromatosis-like phenotype.	Iron	89-93	cystathionine beta-synthase	Mus musculus	14-17
28859237-3	2018	We found that CBS knockout (CBS-/- ) mice exhibited anemia and a significant increase in iron content in the serum, liver, spleen, and heart, along with severe damage to the liver, displaying a hemochromatosis-like phenotype.	Iron	89-93	cystathionine beta-synthase	Mus musculus	28-31
28859237-5	2018	A major cause of the systemic iron overload is the reduced iron usage due to suppressed erythropoiesis, which is consistent with an increase in interleukin-6 and reduced expression of erythropoietin.	Iron	30-34	erythropoietin	Mus musculus	184-198
28859237-5	2018	A major cause of the systemic iron overload is the reduced iron usage due to suppressed erythropoiesis, which is consistent with an increase in interleukin-6 and reduced expression of erythropoietin.	Iron	59-63	erythropoietin	Mus musculus	184-198
28859237-6	2018	Importantly, in the liver, absence of CBS caused both a reduction in the transcriptional factor nuclear factor erythroid 2-related factor-2 and an up-regulation of hepcidin that led to a decrease in the iron export protein ferroportin 1.	Iron	203-207	cystathionine beta-synthase	Mus musculus	38-41
28859237-8	2018	Finally, administration of CBS-overexpressing adenovirus into CBS mutant mice could partially reverse the iron-related phenotype.	Iron	106-110	cystathionine beta-synthase	Mus musculus	27-30
28859237-8	2018	Finally, administration of CBS-overexpressing adenovirus into CBS mutant mice could partially reverse the iron-related phenotype.	Iron	106-110	cystathionine beta-synthase	Mus musculus	62-65
29177643-1	2018	Iron overload (IOL) starts to develop in MDS patients before they become transfusion-dependent because ineffective erythropoiesis suppresses hepcidin production in the liver and thus leads to unrestrained intestinal iron uptake.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	141-149
29362518-1	2018	Iron transport across the intestinal epithelium is facilitated by the divalent metal transporter 1 (DMT1) on the brush border membrane (BBM).	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	70-98
29362518-1	2018	Iron transport across the intestinal epithelium is facilitated by the divalent metal transporter 1 (DMT1) on the brush border membrane (BBM).	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	100-104
29173474-13	2018	New evidence is that MT2A -5A/G SNP was associated with decreased placental Fe levels in non-smokers.	Iron	76-78	metallothionein 2A	Homo sapiens	21-25
29261151-2	2017	Current models for iron metabolism in patients with NTDT suggest that suppression of serum hepcidin leads to an increase in iron absorption and subsequent release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	91-99
29261151-2	2017	Current models for iron metabolism in patients with NTDT suggest that suppression of serum hepcidin leads to an increase in iron absorption and subsequent release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	91-99
29261151-2	2017	Current models for iron metabolism in patients with NTDT suggest that suppression of serum hepcidin leads to an increase in iron absorption and subsequent release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	91-99
29261151-2	2017	Current models for iron metabolism in patients with NTDT suggest that suppression of serum hepcidin leads to an increase in iron absorption and subsequent release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	91-99
29261151-2	2017	Current models for iron metabolism in patients with NTDT suggest that suppression of serum hepcidin leads to an increase in iron absorption and subsequent release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	91-99
29222265-3	2017	The predominant mechanisms driving the process of iron loading include increased iron burden secondary to transfusion therapy in TDT and enhanced intestinal absorption secondary to ineffective erythropoiesis and hepcidin suppression in NTDT.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	212-220
29070542-2	2017	To meet these iron requirements, both dietary iron absorption and the mobilization of iron from stores increase, a mechanism that is in large part dependent on the iron-regulatory hormone hepcidin.	Iron	14-18	hepcidin antimicrobial peptide	Homo sapiens	188-196
29070542-2	2017	To meet these iron requirements, both dietary iron absorption and the mobilization of iron from stores increase, a mechanism that is in large part dependent on the iron-regulatory hormone hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	188-196
29070542-2	2017	To meet these iron requirements, both dietary iron absorption and the mobilization of iron from stores increase, a mechanism that is in large part dependent on the iron-regulatory hormone hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	188-196
29070542-3	2017	In healthy human pregnancies, maternal hepcidin concentrations are suppressed in the second and third trimesters, thereby facilitating an increased supply of iron into the circulation.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	39-47
29070542-4	2017	The mechanism of maternal hepcidin suppression in pregnancy is unknown, but hepcidin regulation by the known stimuli (i.e., iron, erythropoietic activity, and inflammation) appears to be preserved during pregnancy.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	76-84
29070542-5	2017	Inappropriately increased maternal hepcidin during pregnancy can compromise the iron availability for placental transfer and impair the efficacy of iron supplementation.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	35-43
29070542-5	2017	Inappropriately increased maternal hepcidin during pregnancy can compromise the iron availability for placental transfer and impair the efficacy of iron supplementation.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	35-43
29070542-6	2017	The role of fetal hepcidin in the regulation of placental iron transfer still remains to be characterized.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	18-26
29260001-6	2017	Differential dynamics of hepcidin during PEG-IFNalpha/RBV therapy in responders and non-responders might indicate the direct influence of viral eradication on iron homeostasis.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	25-33
27484685-9	2017	CONCLUSIONS: Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.	Iron	23-27	leptin	Homo sapiens	96-102
29079528-2	2017	Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense.	Iron	78-82	ceruloplasmin	Homo sapiens	26-39
28703464-1	2017	Though serum iron has been known to be associated with an increased risk of infection, hepcidin, the major regulator of iron metabolism, has never been systematically explored in this setting.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	87-95
28703464-5	2017	After adjusting for perioperative bleeding complications, number of hospital days, and hepatic artery thrombosis, changes in iron markers were associated with the development of infection post-OLT including increasing ferritin (hazard ratio [HR], 1.51; 95% confidence interval [CI], 1.12-2.05), rising ferritin slope (HR, 1.10; 95% CI, 1.03-1.17), and increasing hepcidin (HR, 1.43; 95% CI, 1.05-1.93).	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	363-371
29129410-0	2017	Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	60-68
29147080-3	2017	It has been reported that ineffective erythropoiesis enhances iron absorption in MDS through downregulation of hepcidin and its prohormones such that SF rises.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	111-119
28803783-3	2017	LIAS is an iron-sulfur (Fe-S) cluster-containing mitochondrial protein, like mitochondrial aconitase (mt-aco) and some subunits of respiratory chain (RC) complexes I, II and III.	Iron	24-28	lipoic acid synthetase	Homo sapiens	0-4
29089493-6	2017	Our results suggest that Fe-rich clay minerals such as nontronite can form rapidly under oxidized conditions, which could help explain low concentrations of organics within some smectite-containing rocks or sediments on Mars.	Iron	25-27	methionyl-tRNA synthetase 1	Homo sapiens	220-224
28826751-1	2017	Genetic medicine applied to the study of hemochromatosis has identified the systemic loop controlling iron homeostasis, centered on hepcidin-ferroportin interaction.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	132-140
28826751-2	2017	Current challenges are to dissect the molecular pathways underlying liver hepcidin synthesis in response to circulatory iron, HFE, TFR2, HJV, TMPRSS6 and BMP6 functions, and to define the major structural elements of hepcidin-ferroportin interaction.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	74-82
28826751-5	2017	Results revealed novel amino acids that are critical for the iron export function and the hepcidin-mediated inhibition mechanism: for example, tryptophan 42, localized in the extracellular end of the ferroportin pore and involved in both biological functions.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	90-98
28774878-0	2017	The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.	Iron	61-65	profilin 2	Mus musculus	26-36
28774878-2	2017	We identified profilin 2 (Pfn2) mRNA, which encodes an actin-binding protein involved in endocytosis and neurotransmitter release, as a novel IRP-interacting transcript, and studied its role in iron metabolism.	Iron	194-198	profilin 2	Mus musculus	14-24
28774878-6	2017	Importantly, Pfn2-deficient mice showed iron accumulation in discrete areas of the brain (olfactory bulb, hippocampus, and midbrain) and reduction of the hepatic iron store without anemia.	Iron	40-44	profilin 2	Mus musculus	13-17
28774878-6	2017	Importantly, Pfn2-deficient mice showed iron accumulation in discrete areas of the brain (olfactory bulb, hippocampus, and midbrain) and reduction of the hepatic iron store without anemia.	Iron	162-166	profilin 2	Mus musculus	13-17
28774878-9	2017	Overall, our results indicate that Pfn2 expression is controlled by the IRPs in vivo and that Pfn2 contributes to maintaining iron homeostasis in cell lines and mice.	Iron	126-130	profilin 2	Mus musculus	94-98
29065180-3	2017	We aimed to assess the relationship between levels of hepcidin, the master iron-regulatory protein, in plasma and the presence of NAFLD in morbidly obese (MO) patients, and to investigate the association between the hepatic expression of the main iron and lipid metabolism -related genes.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	54-62
29065180-9	2017	Moreover, a positive association of hepatic hepcidin mRNA expression and the iron metabolism-related genes was found with some key genes involved in the lipid metabolism.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	44-52
28938074-6	2017	Similar to the previously reported results on cytochrome c, these fragment ions form near residues known to interact with iron atoms in solution.	Iron	122-126	cytochrome c, somatic	Equus caballus	46-58
28793182-2	2017	Herein, we demonstrate the potential of Cu(CF3 SO3 ) for the construction of the novel 2D polymer [{Cp*Fe(mu4 ,eta5:1:1:1 -P5 )}{Cu(CF3 SO3 )}]n (2) and the unprecedented nanosphere (CH2 Cl2 )1.4 @[{CpBn Fe(eta5 -P5 )}12 {Cu(CF3 SO3 )}19.6 ] (3).	Iron	103-105	adaptor related protein complex 4 subunit mu 1	Homo sapiens	106-109
28648620-7	2017	Even if iron challenge of in vitro neuronal models (GN-11 and GT1-7 GnRH cells) resulted in 10- and 5-fold iron content increments, respectively, no iron content changes were found in vivo in hypothalamus of IED mice.	Iron	8-12	gonadotropin releasing hormone 1	Mus musculus	68-72
29023457-2	2017	Iron enters the enterocytes through an apical divalent metal transporter, DMT1.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	74-78
29023457-3	2017	Different DMT1 transcripts have been identified, depending on the presence of an iron-responsive element that allows DMT1 up-regulation during iron starvation.	Iron	81-85	solute carrier family 11 member 2	Homo sapiens	10-14
29023457-3	2017	Different DMT1 transcripts have been identified, depending on the presence of an iron-responsive element that allows DMT1 up-regulation during iron starvation.	Iron	81-85	solute carrier family 11 member 2	Homo sapiens	117-121
29023457-3	2017	Different DMT1 transcripts have been identified, depending on the presence of an iron-responsive element that allows DMT1 up-regulation during iron starvation.	Iron	143-147	solute carrier family 11 member 2	Homo sapiens	10-14
29023457-3	2017	Different DMT1 transcripts have been identified, depending on the presence of an iron-responsive element that allows DMT1 up-regulation during iron starvation.	Iron	143-147	solute carrier family 11 member 2	Homo sapiens	117-121
29023457-4	2017	An intronic DMT1 polymorphism, IVS4+44C&gt;A, has been associated with metal toxicity, and the CC-carriers show high iron levels.	Iron	117-121	solute carrier family 11 member 2	Homo sapiens	12-16
29023457-8	2017	Moreover, we found that A-allele is associated to preferential expression of the DMT1 transcripts lacking the iron-responsive element, thus limiting the DMT1 overexpression that normally occurs to respond to iron starvation.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	81-85
29023457-8	2017	Moreover, we found that A-allele is associated to preferential expression of the DMT1 transcripts lacking the iron-responsive element, thus limiting the DMT1 overexpression that normally occurs to respond to iron starvation.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	153-157
29023457-8	2017	Moreover, we found that A-allele is associated to preferential expression of the DMT1 transcripts lacking the iron-responsive element, thus limiting the DMT1 overexpression that normally occurs to respond to iron starvation.	Iron	208-212	solute carrier family 11 member 2	Homo sapiens	81-85
29023457-8	2017	Moreover, we found that A-allele is associated to preferential expression of the DMT1 transcripts lacking the iron-responsive element, thus limiting the DMT1 overexpression that normally occurs to respond to iron starvation.	Iron	208-212	solute carrier family 11 member 2	Homo sapiens	153-157
29023457-9	2017	DISCUSSION: Possibly, the IVS4+44-AA-related dysregulation of the iron-induced changes in DMT1 expression is not able to impair iron absorption in physiological condition.	Iron	66-70	solute carrier family 11 member 2	Homo sapiens	90-94
28289833-3	2017	CTH2 is up-regulated upon iron starvation and functions to remodel metabolism to adapt to iron starvation.	Iron	26-30	Tis11p	Saccharomyces cerevisiae S288C	0-4
28289833-3	2017	CTH2 is up-regulated upon iron starvation and functions to remodel metabolism to adapt to iron starvation.	Iron	90-94	Tis11p	Saccharomyces cerevisiae S288C	0-4
28289833-7	2017	We further showed that supplementation of iron in medium augmented the growth of S. cerevisiae under oxidative stress, and expression of CTH2 and supplementation of iron collectively enhanced its growth under oxidative stress.	Iron	42-46	Tis11p	Saccharomyces cerevisiae S288C	137-141
28289833-8	2017	Since CTH2 is regulated by iron, these findings suggested that iron played crucial roles in the regulation of oxidative stress in S. cerevisiae.	Iron	27-31	Tis11p	Saccharomyces cerevisiae S288C	6-10
28289833-8	2017	Since CTH2 is regulated by iron, these findings suggested that iron played crucial roles in the regulation of oxidative stress in S. cerevisiae.	Iron	63-67	Tis11p	Saccharomyces cerevisiae S288C	6-10
28370178-2	2017	Hepcidin is upregulated during inflammation through the activation of the signal transducer and activator of transcription 3 (STAT3) transduction pathway, which decreases iron bioavailability and may explain the anemia of chronic inflammatory disease.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	0-8
31556266-1	2017	Aim: To evaluate reticulocyte hemoglobin (RET-Hb) vis-a-vis immature reticulocyte fraction (IRF) as an earliest indicator of response to iron therapy in iron deficiency anemia (IDA), by assessing change in RET-He and IRF at 48 hours after initiation of intravenous iron therapy.	Iron	137-141	ret proto-oncogene	Homo sapiens	42-45
31556266-1	2017	Aim: To evaluate reticulocyte hemoglobin (RET-Hb) vis-a-vis immature reticulocyte fraction (IRF) as an earliest indicator of response to iron therapy in iron deficiency anemia (IDA), by assessing change in RET-He and IRF at 48 hours after initiation of intravenous iron therapy.	Iron	153-157	ret proto-oncogene	Homo sapiens	42-45
31556266-10	2017	RET-He and IRF increased significantly at 48 hours after initiation of intravenous iron therapy (post therapy) as compared to baseline (pre therapy) in both the two groups as well when all patients were considered together.	Iron	83-87	ret proto-oncogene	Homo sapiens	0-3
31556266-13	2017	Conclusion: RET-Hb, a real time indicator of iron supply (hemoglobinization) to the developing RBC"s, is the earliest marker of response to iron therapy as compared to IRF (representative of reticulocyte count).	Iron	45-49	ret proto-oncogene	Homo sapiens	12-15
31556266-13	2017	Conclusion: RET-Hb, a real time indicator of iron supply (hemoglobinization) to the developing RBC"s, is the earliest marker of response to iron therapy as compared to IRF (representative of reticulocyte count).	Iron	140-144	ret proto-oncogene	Homo sapiens	12-15
29364423-10	2017	The serum levels of the hormone hepcidin, which regulates iron availability, are similar in individuals at high altitudes to those of individuals at sea level, indicating that iron deficiency does not occur at high altitudes.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	32-40
30090556-0	2017	Evaluation of the toxicity of iron-ion irradiation in murine bone marrow dendritic cells via increasing the expression of indoleamine 2,3-dioxygenase 1.	Iron	30-34	indoleamine 2,3-dioxygenase 1	Mus musculus	122-151
28894875-1	2017	We here demonstrate that the iron derived from an iron-based metal-organic framework (MOF), with exposed high-density Fe-atom planes, exhibits improved reduction activity, enabling good rechargeability of solid oxide iron-air redox batteries at 500  C. The discharge mass specific energies are 226.5 W h kg-1-Fe and 214.8 W h kg-1-Fe at C/4 and C/3, respectively, at a constant Fe-utilization of 20%.	Iron	29-33	complement C4A (Rodgers blood group)	Homo sapiens	337-348
28894875-1	2017	We here demonstrate that the iron derived from an iron-based metal-organic framework (MOF), with exposed high-density Fe-atom planes, exhibits improved reduction activity, enabling good rechargeability of solid oxide iron-air redox batteries at 500  C. The discharge mass specific energies are 226.5 W h kg-1-Fe and 214.8 W h kg-1-Fe at C/4 and C/3, respectively, at a constant Fe-utilization of 20%.	Iron	50-54	complement C4A (Rodgers blood group)	Homo sapiens	337-348
28894875-1	2017	We here demonstrate that the iron derived from an iron-based metal-organic framework (MOF), with exposed high-density Fe-atom planes, exhibits improved reduction activity, enabling good rechargeability of solid oxide iron-air redox batteries at 500  C. The discharge mass specific energies are 226.5 W h kg-1-Fe and 214.8 W h kg-1-Fe at C/4 and C/3, respectively, at a constant Fe-utilization of 20%.	Iron	118-120	complement C4A (Rodgers blood group)	Homo sapiens	337-348
28894875-1	2017	We here demonstrate that the iron derived from an iron-based metal-organic framework (MOF), with exposed high-density Fe-atom planes, exhibits improved reduction activity, enabling good rechargeability of solid oxide iron-air redox batteries at 500  C. The discharge mass specific energies are 226.5 W h kg-1-Fe and 214.8 W h kg-1-Fe at C/4 and C/3, respectively, at a constant Fe-utilization of 20%.	Iron	50-54	complement C4A (Rodgers blood group)	Homo sapiens	337-348
28936123-1	2017	In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, using the absence of stainable bone marrow iron as the diagnostic criterion for iron deficiency.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	29-37
28914813-1	2017	Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses.	Iron	28-32	HLF transcription factor, PAR bZIP family member	Homo sapiens	19-22
28914813-2	2017	HLf and bovine Lf (bLf), possessing high sequence homology and identical functions, inhibit bacterial growth and biofilm dependently from iron binding ability while, independently, bacterial adhesion to and the entry into cells.	Iron	138-142	HLF transcription factor, PAR bZIP family member	Homo sapiens	1-3
28967645-7	2017	In cells with CSC characteristics an increased expression of transferrin and its receptor, ferritin, fentorin and hepcidin was revealed indicating activation of the endogenous iron metabolism.	Iron	176-180	hepcidin antimicrobial peptide	Homo sapiens	114-122
28451750-1	2017	MAIN CONCLUSION: Expression of bHLH104 - GFP driven by the MYB72 promoter improves plants" tolerance to Fe deficiency and increases seed Fe concentrations.	Iron	104-106	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	31-38
28451750-1	2017	MAIN CONCLUSION: Expression of bHLH104 - GFP driven by the MYB72 promoter improves plants" tolerance to Fe deficiency and increases seed Fe concentrations.	Iron	104-106	myb domain protein 72	Arabidopsis thaliana	59-64
28451750-11	2017	When grown in alkaline soil, Pro MYB72 :bHLH104-GFP plants greatly improved the seed yield and Fe concentration.	Iron	95-97	myb domain protein 72	Arabidopsis thaliana	33-38
28694024-3	2017	Hepcidin, which is synthesized predominantly by the liver, is the main regulator of iron metabolism.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
28694024-4	2017	Hepcidin reduces serum iron by inhibiting the iron exporter, ferroportin expressed both tissues, the intestine and the macrophages.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
28694024-4	2017	Hepcidin reduces serum iron by inhibiting the iron exporter, ferroportin expressed both tissues, the intestine and the macrophages.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
28694024-5	2017	In addition, in the enterocytes, hepcidin inhibits the iron influx by acting on the apical transporter, DMT1.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	33-41
28694024-5	2017	In addition, in the enterocytes, hepcidin inhibits the iron influx by acting on the apical transporter, DMT1.	Iron	55-59	doublesex and mab-3 related transcription factor 1	Homo sapiens	104-108
28694024-6	2017	A defect of hepcidin expression leading to the appearance of a parenchymal iron overload may be genetic or secondary to dyserythropoiesis.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	12-20
28694024-13	2017	In the heart, hepcidin maintains tissue iron homeostasis by an autocrine regulation of ferroprotine expression on the surface of cardiomyocytes.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	14-22
28694024-14	2017	In conclusion, hepcidin remains a promising therapeutic tool in various iron pathologies.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	15-23
28841871-11	2017	Correcting levels of hepcidin is important for reducing iron-overload, which is a risk factor for diabetes.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	21-29
28842692-3	2017	Fe3O4-Fe nanohybrids-containing electrodes exhibited a high discharge capacity (13,890 mA h gc-1 at a current density of 500 mA gc-1), long cycle stability (100 cycles at a current rate of 500 mA gc-1 and fixed capacity regime of 1,000 mA h gc-1), and low overpotential (1.39 V at 40 cycles).	Iron	0-2	solute carrier family 25 member 22	Homo sapiens	128-132
28655775-0	2017	The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer.	Iron	4-8	heme oxygenase 1	Homo sapiens	73-89
28655775-1	2017	Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.	Iron	51-55	heme oxygenase 1	Homo sapiens	93-109
28655775-1	2017	Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.	Iron	51-55	heme oxygenase 1	Homo sapiens	111-114
28655775-1	2017	Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.	Iron	208-212	heme oxygenase 1	Homo sapiens	93-109
28655775-1	2017	Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.	Iron	208-212	heme oxygenase 1	Homo sapiens	111-114
28655775-2	2017	Moreover, intestinal iron is incorporated as ferrous iron, which is transported via the iron importer, divalent metal transporter 1 (DMT1).	Iron	21-25	solute carrier family 11 member 2	Homo sapiens	103-131
28655775-2	2017	Moreover, intestinal iron is incorporated as ferrous iron, which is transported via the iron importer, divalent metal transporter 1 (DMT1).	Iron	21-25	solute carrier family 11 member 2	Homo sapiens	133-137
28655775-2	2017	Moreover, intestinal iron is incorporated as ferrous iron, which is transported via the iron importer, divalent metal transporter 1 (DMT1).	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	103-131
28655775-2	2017	Moreover, intestinal iron is incorporated as ferrous iron, which is transported via the iron importer, divalent metal transporter 1 (DMT1).	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	133-137
28655775-2	2017	Moreover, intestinal iron is incorporated as ferrous iron, which is transported via the iron importer, divalent metal transporter 1 (DMT1).	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	103-131
28655775-2	2017	Moreover, intestinal iron is incorporated as ferrous iron, which is transported via the iron importer, divalent metal transporter 1 (DMT1).	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	133-137
28669000-5	2017	These beneficial effects cannot be attributed to oral iron, as increased hepcidin levels, typical in inflammatory states such as HF, preclude resorption of iron from the gut.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	73-81
28501597-2	2017	Systemic iron homeostasis is mainly negatively regulated by the peptide hormone hepcidin, coded by the gene HAMP.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	80-88
28501597-2	2017	Systemic iron homeostasis is mainly negatively regulated by the peptide hormone hepcidin, coded by the gene HAMP.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	108-112
28501597-3	2017	Hepcidin excess may cause iron deficiency, iron-restricted erythropoiesis, and anemia.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	0-8
28501597-4	2017	Conversely, hepcidin insufficiency leads to iron overload and oxidative damage in multiple tissues.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	12-20
28501597-6	2017	It has been reported that hepcidin expression can be suppressed by secreted erythroid factors, including GDF15, TWSG1, GDF11, and ERFE, thereby increasing iron availability for hemoglobin synthesis.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	26-34
28405918-1	2017	Atonal homolog 8 (ATOH8) is defined as a positive regulator of hepcidin transcription, which links erythropoietic activity with iron-sensing molecules.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	63-71
28341391-7	2017	Increased injury in KO +Fe was associated with activated protein kinase B (AKT), ERK, and NF-kappaB, along with reappearance of beta-catenin and target gene Cyp2e1, which promoted lipid peroxidation and hepatic damage.	Iron	24-26	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	157-163
28206992-2	2017	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme by which heme is catabolized to biliverdin and thence to bilirubin, with the simultaneous release of equimolar quantities of ferrous iron (Fe3+) and carbon monoxide.	Iron	185-189	heme oxygenase 1	Homo sapiens	0-16
28206992-2	2017	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme by which heme is catabolized to biliverdin and thence to bilirubin, with the simultaneous release of equimolar quantities of ferrous iron (Fe3+) and carbon monoxide.	Iron	185-189	heme oxygenase 1	Homo sapiens	18-22
28678785-6	2017	This lipid metabolism creates a dependency on pathways converging on the phospholipid glutathione peroxidase (GPX4), a selenocysteine-containing enzyme that dissipates lipid peroxides and thereby prevents the iron-mediated reactions of peroxides that induce ferroptotic cell death.	Iron	209-213	glutathione peroxidase 4	Homo sapiens	110-114
28840060-2	2017	Mitochondrial ferritin (FtMt) is identified as an iron-storage protein located in the mitochondria, and its role in regulation of iron hemeostasis in neurodegenerative diseases has been reported.	Iron	50-54	ferritin mitochondrial	Homo sapiens	0-22
28840060-2	2017	Mitochondrial ferritin (FtMt) is identified as an iron-storage protein located in the mitochondria, and its role in regulation of iron hemeostasis in neurodegenerative diseases has been reported.	Iron	50-54	ferritin mitochondrial	Homo sapiens	24-28
28840060-7	2017	We further explored the mechanism of these protective effects and found that FtMt expression markedly altered iron homeostasis of the H2O2 treated cells as compared to that of controls.	Iron	110-114	ferritin mitochondrial	Homo sapiens	77-81
28840060-8	2017	The FtMt overexpression significantly reduced cellular labile iron pool (LIP) and protected H2O2-induced elevation on LIP.	Iron	62-66	ferritin mitochondrial	Homo sapiens	4-8
28840060-9	2017	While in H2O2 treated SH-SY5Y cells, the increased iron uptake and reduced iron release, in correlation with levels of DMT1(-IRE) and ferroportin 1, resulted in heavy iron accumulation, the FtMt overexpressing cells didn"t show any significant changes in levels of iron transport proteins and in the level of LIP.	Iron	51-55	ferritin mitochondrial	Homo sapiens	190-194
28840060-9	2017	While in H2O2 treated SH-SY5Y cells, the increased iron uptake and reduced iron release, in correlation with levels of DMT1(-IRE) and ferroportin 1, resulted in heavy iron accumulation, the FtMt overexpressing cells didn"t show any significant changes in levels of iron transport proteins and in the level of LIP.	Iron	75-79	ferritin mitochondrial	Homo sapiens	190-194
28840060-9	2017	While in H2O2 treated SH-SY5Y cells, the increased iron uptake and reduced iron release, in correlation with levels of DMT1(-IRE) and ferroportin 1, resulted in heavy iron accumulation, the FtMt overexpressing cells didn"t show any significant changes in levels of iron transport proteins and in the level of LIP.	Iron	75-79	ferritin mitochondrial	Homo sapiens	190-194
28769786-5	2017	We recently described that 18-month-old NF-kappaB/c-Rel deficient mice (c-rel-/-) develop a spontaneous late-onset PD-like phenotype encompassing L-DOPA-responsive motor impairment, nigrostriatal neuron degeneration, alpha-synuclein and iron accumulation.	Iron	237-241	reticuloendotheliosis oncogene	Mus musculus	72-77
28276006-3	2017	The aim of this study was to evaluate plasma levels of hepcidin in patients with PCOS and its correlation with serum iron level.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	55-63
28276006-12	2017	This implies the need for more comprehensive studies on gene expression in hepcidin and iron pathways using real-time and Western techniques to investigate more precisely serum hepcidin level and its relationship with the factors mentioned.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	177-185
28515164-9	2017	Furthermore, mRNA expression of ZIP1 was 85% lower in the PE+MMN group than in the PE group (P = 0.003).Conclusion: In conditions of low maternal iron and in the absence of supplemental zinc, the placenta upregulates the gene expression of iron and zinc uptake proteins, presumably in order to meet fetal demands in the face of low maternal supply.	Iron	146-150	solute carrier family 39 member 1	Homo sapiens	32-36
28515164-9	2017	Furthermore, mRNA expression of ZIP1 was 85% lower in the PE+MMN group than in the PE group (P = 0.003).Conclusion: In conditions of low maternal iron and in the absence of supplemental zinc, the placenta upregulates the gene expression of iron and zinc uptake proteins, presumably in order to meet fetal demands in the face of low maternal supply.	Iron	240-244	solute carrier family 39 member 1	Homo sapiens	32-36
28476317-2	2017	Its FMN cofactor accepts two electrons from NADH and transfers them to ubiquinone via a chain of iron-sulphur centers.	Iron	97-101	formin 1	Homo sapiens	4-7
28521058-3	2017	In a recent proteomic study (Kong et al., 2016), several components of this system were up-regulated in high feed efficiency (FE) compared to low FE breast muscle; notably adenine nucleotide translocase (ANT), voltage dependent activated channel (VDAC), the brain isoform of creatine kinase (CK-B), and several proteins of the electron transport chain.	Iron	126-128	solute carrier family 25 member 6	Homo sapiens	172-202
28521058-3	2017	In a recent proteomic study (Kong et al., 2016), several components of this system were up-regulated in high feed efficiency (FE) compared to low FE breast muscle; notably adenine nucleotide translocase (ANT), voltage dependent activated channel (VDAC), the brain isoform of creatine kinase (CK-B), and several proteins of the electron transport chain.	Iron	126-128	solute carrier family 25 member 6	Homo sapiens	204-207
29296759-0	2017	A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2.	Iron	36-40	transferrin receptor 2	Homo sapiens	83-105
29296759-6	2017	TfR2, in contrast to its paralog TfR1, has established roles in iron sensing, but not iron uptake.	Iron	64-68	transferrin receptor 2	Homo sapiens	0-4
29296759-11	2017	Human TFR2 shares a lineage- and stage-specific expression pattern with MCOLN1, encoding a lysosomal iron channel, and MFN2, encoding a protein mediating organelle contacts.	Iron	101-105	transferrin receptor 2	Homo sapiens	6-10
29296759-13	2017	These findings identify a new pathway for erythroid iron trafficking involving TfR2-mediated lysosomal delivery followed by interorganelle transfer to mitochondria.	Iron	52-56	transferrin receptor 2	Homo sapiens	79-83
28651003-9	2017	The eAT histology revealed iron retention, macrophage clustering, tissue fibrosis, cell death as well as accumulation of HIF-2alpha in the high iron eAT.	Iron	144-148	endothelial PAS domain protein 1	Mus musculus	121-131
28652624-4	2017	Markers of inflammation and iron status were positively associated with serum hepcidin level, regardless of CKD stage.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	78-86
28640867-0	2017	Correction: L-Ferritin Binding to Scara5: A New Iron Traffic Pathway Potentially Implicated in Retinopathy.	Iron	48-52	scavenger receptor class A member 5	Homo sapiens	34-40
28622511-3	2017	Here, we demonstrate that induction of the iron-sequestering ferritin H chain (FTH) in response to polymicrobial infections is critical to establish disease tolerance to sepsis.	Iron	43-47	ferritin heavy chain 1	Homo sapiens	61-77
28622511-3	2017	Here, we demonstrate that induction of the iron-sequestering ferritin H chain (FTH) in response to polymicrobial infections is critical to establish disease tolerance to sepsis.	Iron	43-47	ferritin heavy chain 1	Homo sapiens	79-82
28622511-4	2017	The protective effect of FTH is exerted via a mechanism that counters iron-driven oxidative inhibition of the liver glucose-6-phosphatase (G6Pase), and in doing so, sustains endogenous glucose production via liver gluconeogenesis.	Iron	70-74	ferritin heavy chain 1	Homo sapiens	25-28
28592304-0	2017	Post translational changes to alpha-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson"s disease.	Iron	54-58	synuclein alpha	Homo sapiens	30-45
28592304-5	2017	Furthermore, we propose a concept in which acetylation and phosphorylation of alpha-syn modulate endocytic import of iron and vesicle transport of dopamine during normal physiology.	Iron	117-121	synuclein alpha	Homo sapiens	78-87
28592304-6	2017	Disregulated phosphorylation and oxidation of alpha-syn mediate iron and dopamine dependent oxidative stress through impaired cellular location and increase propensity for alpha-syn aggregation.	Iron	64-68	synuclein alpha	Homo sapiens	46-55
28435068-0	2017	Metal-metal interaction mediates the iron induction of Drosophila MtnB.	Iron	37-41	Metallothionein B	Drosophila melanogaster	66-70
28435068-6	2017	Interestingly in this study we found that Drosophila MtnB expression also responds to elevated iron levels in the diet.	Iron	95-99	Metallothionein B	Drosophila melanogaster	53-57
28435068-7	2017	Further investigations revealed that MtnB plays limited roles in iron detoxification, and the direct binding of MtnB to ferrous iron in vitro is also weak.	Iron	128-132	Metallothionein B	Drosophila melanogaster	112-116
28435068-8	2017	The induction of MtnB by iron turns out to be mediated by iron interference of other metals, because EDTA at even a partial concentration of that of iron can suppress this induction.	Iron	25-29	Metallothionein B	Drosophila melanogaster	17-21
28435068-8	2017	The induction of MtnB by iron turns out to be mediated by iron interference of other metals, because EDTA at even a partial concentration of that of iron can suppress this induction.	Iron	58-62	Metallothionein B	Drosophila melanogaster	17-21
28435068-8	2017	The induction of MtnB by iron turns out to be mediated by iron interference of other metals, because EDTA at even a partial concentration of that of iron can suppress this induction.	Iron	58-62	Metallothionein B	Drosophila melanogaster	17-21
28435068-9	2017	Indeed, in the presence of iron, zinc homeostasis is altered, as reflected by expression changes of zinc transporters dZIP1 and dZnT1.	Iron	27-31	Zinc/iron regulated transporter-related protein 42C.1	Drosophila melanogaster	118-123
28435068-10	2017	Thus, iron-mediated MtnB induction appears resulting from interrupted homeostasis of other metals such as zinc, which in turns induced MtnB expression.	Iron	6-10	Metallothionein B	Drosophila melanogaster	20-24
28435068-10	2017	Thus, iron-mediated MtnB induction appears resulting from interrupted homeostasis of other metals such as zinc, which in turns induced MtnB expression.	Iron	6-10	Metallothionein B	Drosophila melanogaster	135-139
28341633-9	2017	PHD2 requires both oxygen and iron as cofactors for the hydroxylation of HIF-1alpha, marking it for ubiquination via VHL and subsequent destruction by the proteasome complex.	Iron	30-34	egl-9 family hypoxia-inducible factor 1	Mus musculus	0-4
28341633-9	2017	PHD2 requires both oxygen and iron as cofactors for the hydroxylation of HIF-1alpha, marking it for ubiquination via VHL and subsequent destruction by the proteasome complex.	Iron	30-34	hypoxia inducible factor 1, alpha subunit	Mus musculus	73-83
28400237-9	2017	Modeling studies show that the presence of a bulky 3,4-dimethoxybenzylamino C9 substituent prevents the orientation of the 1,2,3,4-tetrahydroacridine ring close to the heme-iron center of CYP1A2 thereby reducing the risk of forming hepatotoxic species.	Iron	173-177	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	188-194
28276141-2	2017	A hallmark of ferroptosis is iron-dependent lipid peroxidation, which can be inhibited by the key ferroptosis regulator glutathione peroxidase 4(Gpx4), radical trapping antioxidants and ferroptosis-specific inhibitors, such as ferrostatins and liproxstatins, as well as iron chelation.	Iron	29-33	glutathione peroxidase 4	Homo sapiens	120-144
28276141-2	2017	A hallmark of ferroptosis is iron-dependent lipid peroxidation, which can be inhibited by the key ferroptosis regulator glutathione peroxidase 4(Gpx4), radical trapping antioxidants and ferroptosis-specific inhibitors, such as ferrostatins and liproxstatins, as well as iron chelation.	Iron	29-33	glutathione peroxidase 4	Homo sapiens	145-149
28276141-2	2017	A hallmark of ferroptosis is iron-dependent lipid peroxidation, which can be inhibited by the key ferroptosis regulator glutathione peroxidase 4(Gpx4), radical trapping antioxidants and ferroptosis-specific inhibitors, such as ferrostatins and liproxstatins, as well as iron chelation.	Iron	270-274	glutathione peroxidase 4	Homo sapiens	120-144
28276141-2	2017	A hallmark of ferroptosis is iron-dependent lipid peroxidation, which can be inhibited by the key ferroptosis regulator glutathione peroxidase 4(Gpx4), radical trapping antioxidants and ferroptosis-specific inhibitors, such as ferrostatins and liproxstatins, as well as iron chelation.	Iron	270-274	glutathione peroxidase 4	Homo sapiens	145-149
27932449-8	2017	The inverse relation between baseline CRP and hepcidin levels and the haemoglobin response suggests that CRP or hepcidin measurements could influence decisions on whether iron should be given orally or intravenously.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	46-54
28424258-3	2017	Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin"s diagnostic potential as an index of iron deficiency.Methods: We measured hemoglobin and serum hepcidin, ferritin, soluble transferrin receptor (sTfR), and C-reactive protein (CRP) at 14, 20, and 30 wk of gestation in a cohort of 395 Gambian women recruited to a randomized controlled trial.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	59-67
28424258-3	2017	Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin"s diagnostic potential as an index of iron deficiency.Methods: We measured hemoglobin and serum hepcidin, ferritin, soluble transferrin receptor (sTfR), and C-reactive protein (CRP) at 14, 20, and 30 wk of gestation in a cohort of 395 Gambian women recruited to a randomized controlled trial.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	116-124
28424258-3	2017	Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin"s diagnostic potential as an index of iron deficiency.Methods: We measured hemoglobin and serum hepcidin, ferritin, soluble transferrin receptor (sTfR), and C-reactive protein (CRP) at 14, 20, and 30 wk of gestation in a cohort of 395 Gambian women recruited to a randomized controlled trial.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	116-124
28424258-3	2017	Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin"s diagnostic potential as an index of iron deficiency.Methods: We measured hemoglobin and serum hepcidin, ferritin, soluble transferrin receptor (sTfR), and C-reactive protein (CRP) at 14, 20, and 30 wk of gestation in a cohort of 395 Gambian women recruited to a randomized controlled trial.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	116-124
27717843-1	2017	Lipoic acid synthase (LIAS) is an iron-sulfur cluster mitochondrial enzyme which catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant.	Iron	34-38	lipoic acid synthetase	Homo sapiens	0-20
27717843-1	2017	Lipoic acid synthase (LIAS) is an iron-sulfur cluster mitochondrial enzyme which catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant.	Iron	34-38	lipoic acid synthetase	Homo sapiens	22-26
28881695-2	2017	Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	28-32
28881695-2	2017	Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	47-55
28469086-1	2017	Non-transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions.	Iron	22-26	inhibitor of carbonic anhydrase	Cavia porcellus	4-15
28467369-1	2017	NRAMP1 (SLC11A1) is a professional phagocyte membrane importer of divalent metals that contributes to iron recycling at homeostasis and to nutritional immunity against infection.	Iron	102-106	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
28467369-1	2017	NRAMP1 (SLC11A1) is a professional phagocyte membrane importer of divalent metals that contributes to iron recycling at homeostasis and to nutritional immunity against infection.	Iron	102-106	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	8-15
28476795-7	2017	Real time quantitative polymerase chain reaction showed that iron up-regulated the expression of FTH1 and iron chelator DFOM reduced FTH1 expression of MCF-7 and MDA-MB-231 cells.	Iron	61-65	ferritin heavy chain 1	Homo sapiens	97-101
28476795-7	2017	Real time quantitative polymerase chain reaction showed that iron up-regulated the expression of FTH1 and iron chelator DFOM reduced FTH1 expression of MCF-7 and MDA-MB-231 cells.	Iron	106-110	ferritin heavy chain 1	Homo sapiens	133-137
27125837-8	2017	The presence of two minor alleles in any of the tested SNPs predisposed to abnormally high serum iron concentration and correlated with higher hepatic expression of lncRNA NRIR.	Iron	97-101	negative regulator of interferon response	Homo sapiens	172-176
27125837-11	2017	HAMP mRNA level positively correlated with serum iron indices and degree of hepatocyte iron deposits.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-4
27125837-11	2017	HAMP mRNA level positively correlated with serum iron indices and degree of hepatocyte iron deposits.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-4
28291504-1	2017	BACKGROUND: The discovery of hepcidin, the hormone regulating iron absorption and transport, has improved the understanding of anemia and erythropoietin treatment.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	29-37
28291504-2	2017	Excessive hepcidin signaling causes anemia in chronic inflammatory conditions by restricting iron delivery to the bone marrow.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	10-18
28243792-0	2017	HMOX1 as a marker of iron excess-induced adipose tissue dysfunction, affecting glucose uptake and respiratory capacity in human adipocytes.	Iron	21-25	heme oxygenase 1	Homo sapiens	0-5
28243792-2	2017	Here, we aimed to investigate the possible role of haem oxygenase 1 (HMOX1) in iron excess-induced adipose tissue dysfunction.	Iron	79-83	heme oxygenase 1	Homo sapiens	51-67
28243792-2	2017	Here, we aimed to investigate the possible role of haem oxygenase 1 (HMOX1) in iron excess-induced adipose tissue dysfunction.	Iron	79-83	heme oxygenase 1	Homo sapiens	69-74
28243792-5	2017	RESULTS: Adipose tissue HMOX1 was increased in obese participants (p = 0.01) and positively associated with obesity-related metabolic disturbances, and markers of iron accumulation, inflammation and oxidative stress (p &lt; 0.01).	Iron	163-167	heme oxygenase 1	Homo sapiens	24-29
28243792-10	2017	In human adipocytes, iron excess and inflammation led to increased HMOX1 mRNA levels.	Iron	21-25	heme oxygenase 1	Homo sapiens	67-72
28243792-11	2017	HMOX1 induction (by haem arginate [hemin] administration), resulted in a significant reduction of mitochondrial respiratory capacity (including basal respiration and spare respiratory capacity), glucose uptake and adipogenesis in parallel with increased expression of inflammatory- and iron excess-related genes.	Iron	286-290	heme oxygenase 1	Homo sapiens	0-5
28243792-12	2017	CONCLUSIONS/INTERPRETATION: HMOX1 is an important marker of iron excess-induced adipose tissue dysfunction and metabolic disturbances in human obesity.	Iron	60-64	heme oxygenase 1	Homo sapiens	28-33
28409428-0	2017	Evaluation of zeolite-supported microscale zero-valent iron as a potential adsorbent for Cd2+ and Pb2+ removal in permeable reactive barriers.	Iron	55-59	CD2 molecule	Homo sapiens	89-92
28409428-1	2017	A new composite adsorbent, zeolite-supported microscale zero-valent iron (Z-mZVI) was evaluated as a potential adsorbent for the removal of Cd2+ and Pb2+ from aqueous solution using batch and column experiments.	Iron	68-72	CD2 molecule	Homo sapiens	140-143
28163159-1	2017	Mitochondrial ferritin (FtMt) is a type of ferritin that sequesters iron.	Iron	68-72	ferritin mitochondrial	Homo sapiens	0-22
28163159-1	2017	Mitochondrial ferritin (FtMt) is a type of ferritin that sequesters iron.	Iron	68-72	ferritin mitochondrial	Homo sapiens	24-28
28163159-7	2017	FtMt enhanced the iron levels in mitochondria but decreased the iron levels in the intracellular labile iron pool.	Iron	18-22	ferritin mitochondrial	Homo sapiens	0-4
28163159-7	2017	FtMt enhanced the iron levels in mitochondria but decreased the iron levels in the intracellular labile iron pool.	Iron	64-68	ferritin mitochondrial	Homo sapiens	0-4
28163159-7	2017	FtMt enhanced the iron levels in mitochondria but decreased the iron levels in the intracellular labile iron pool.	Iron	64-68	ferritin mitochondrial	Homo sapiens	0-4
28163159-11	2017	Our results indicate that FtMt modulates alpha-synuclein expression at the posttranscriptional level via iron regulation in physiological conditions.	Iron	105-109	ferritin mitochondrial	Homo sapiens	26-30
28163159-11	2017	Our results indicate that FtMt modulates alpha-synuclein expression at the posttranscriptional level via iron regulation in physiological conditions.	Iron	105-109	synuclein alpha	Homo sapiens	41-56
28167288-4	2017	Because a subset of MDS harbors a somatic mutation of TET2, it may be involved in iron metabolism and/or heme biosynthesis in erythroblasts.	Iron	82-86	tet methylcytosine dioxygenase 2	Mus musculus	54-58
28167288-7	2017	Quantitative real-time polymerase chain reaction demonstrated significant dysregulation of genes involved in iron and heme metabolism, including Hmox1, Fech, Abcb7, and Sf3b1 downregulation.	Iron	109-113	splicing factor 3b, subunit 1	Mus musculus	169-174
28167288-10	2017	Therefore, TET2 plays a role in the iron and heme metabolism in erythroblasts.	Iron	36-40	tet methylcytosine dioxygenase 2	Mus musculus	11-15
28414228-1	2017	Ceruloplasmin (Cp) is one of the most complex multicopper oxidase enzymes and plays an essential role in the metabolism of iron in mammals.	Iron	123-127	ceruloplasmin	Homo sapiens	0-13
28428736-4	2017	This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is hormone regulating iron metabolism.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	114-122
28428736-12	2017	CONCLUSIONS: These data suggest that protective effects of exercise on excess iron accumulation in human body which is mediated by hepcidin can be abrogated by high sugar consumption which is typical for contemporary people.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	131-139
28427446-2	2017	The assembly of the eleven-subunit CIII is completed by the insertion of the Rieske iron-sulfur protein, a process for which BCS1L protein is indispensable.	Iron	84-88	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	125-130
28213091-5	2017	TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine.	Iron	114-116	hepcidin antimicrobial peptide 2	Mus musculus	73-78
28380382-5	2017	The five Fe-S cluster subunits of Complex I also interact with HSC20 to acquire their clusters, highlighting the crucial role of HSC20 in the assembly of the mitochondrial respiratory chain.	Iron	9-11	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	63-68
28380382-5	2017	The five Fe-S cluster subunits of Complex I also interact with HSC20 to acquire their clusters, highlighting the crucial role of HSC20 in the assembly of the mitochondrial respiratory chain.	Iron	9-11	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	129-134
28287409-0	2017	Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.	Iron	29-33	sirtuin 2	Mus musculus	0-9
28287409-2	2017	Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis.	Iron	30-34	sirtuin 2	Mus musculus	57-62
28287409-2	2017	Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis.	Iron	91-95	sirtuin 2	Mus musculus	57-62
28287409-3	2017	Here, we have demonstrated that SIRT2 depletion results in a decrease in cellular iron levels both in vitro and in vivo.	Iron	82-86	sirtuin 2	Mus musculus	32-37
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Iron	61-65	sirtuin 2	Mus musculus	36-41
28287409-6	2017	Finally, we observed that Sirt2 deletion reduced cell viability in response to iron deficiency.	Iron	79-83	sirtuin 2	Mus musculus	26-31
28287409-7	2017	Moreover, livers from Sirt2-/- mice had decreased iron levels, while this effect was reversed in Sirt2-/- Nrf2-/- double-KO mice.	Iron	50-54	sirtuin 2	Mus musculus	22-27
28534724-9	2017	These results indicate that maternal protein restriction during pregnancy and lactation influences growth of female offspring at weaning, reduces duodenal expression of Fe transporters (DMT1 and FPN) and decreases serum Fe level in male weaning piglets.	Iron	169-171	solute carrier family 11 member 2	Homo sapiens	186-190
28464091-7	2017	These results indicated that organic Fe sources with greater Q values showed higher Fe absorption; however, all Fe sources followed the same saturated carrier-dependent transport process in the duodenum, and DMT1 and FPN1 might participate in Fe absorption in the duodenum of broilers regardless of Fe source.	Iron	37-39	solute carrier family 40 member 1	Homo sapiens	217-221
28346059-5	2017	UGT1A1 rs887829TT (p = 0.002) and CYP1A2 rs762551CC (p = 0.019) resulted as predictive factor of ferritin levels and CYP1A1 rs2606345CA/AA (p = 0.021) and CYP1A2 rs762551AC/CC (p = 0.027) of liver iron concentration.	Iron	197-201	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
28424608-3	2017	We observed a significant downregulation of genes related to hemoglobin including, hemoglobin delta (HBD), alpha hemoglobin stabilizing protein (ASHP), genes implicated in iron metabolism including, solute carrier family 11 member 2 (SLC11A2), ferrochelatase (FECH), and erythrocyte-specific genes including erythrocyte membrane protein (EPB42), and 5"-aminolevulinate synthase 2 (ALAS2).	Iron	172-176	solute carrier family 11 member 2	Homo sapiens	199-232
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	42-46	secreted phosphoprotein 1	Homo sapiens	94-98
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	42-46	secreted phosphoprotein 1	Homo sapiens	99-103
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	66-68	secreted phosphoprotein 1	Homo sapiens	94-98
28265627-2	2017	of elemental sulfur (S8) gave a dinuclear iron-sulfur cluster [Cp*Fe(mu-eta2:eta2-bdt)(cis-mu-eta1:eta1-S2)FeCp*] (2), which contains a cis-1,2-disulfide ligand.	Iron	66-68	secreted phosphoprotein 1	Homo sapiens	99-103
28265627-4	2017	of S8, another sulfur atom inserted into an Fe-S bond to give a rare product [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*] (3).	Iron	44-46	secreted phosphoprotein 1	Homo sapiens	105-109
28265627-4	2017	of S8, another sulfur atom inserted into an Fe-S bond to give a rare product [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*] (3).	Iron	44-46	secreted phosphoprotein 1	Homo sapiens	110-114
28265627-4	2017	of S8, another sulfur atom inserted into an Fe-S bond to give a rare product [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*] (3).	Iron	81-83	secreted phosphoprotein 1	Homo sapiens	105-109
28265627-4	2017	of S8, another sulfur atom inserted into an Fe-S bond to give a rare product [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta1:eta1-S2)FeCp*] (3).	Iron	81-83	secreted phosphoprotein 1	Homo sapiens	110-114
28300826-6	2017	Disrupting astrocyte hepcidin expression prevented the apoptosis of neurons, which were able to maintain levels of FPN1 adequate to avoid iron accumulation.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	21-29
28300826-7	2017	Together, our data are consistent with a model whereby inflammation initiates an intercellular signaling cascade in which activated microglia, through IL-6 signaling, stimulate astrocytes to release hepcidin which, in turn, signals to neurons, via hepcidin, to prevent their iron release.	Iron	275-279	hepcidin antimicrobial peptide	Homo sapiens	199-207
28130443-0	2017	Na+/H+ Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation.	Iron	29-33	solute carrier family 9 member A9	Homo sapiens	0-18
28130443-0	2017	Na+/H+ Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation.	Iron	89-93	solute carrier family 9 member A9	Homo sapiens	0-18
28130443-6	2017	In hBMVECs, we show that NHE9 expression is up-regulated very early in a physiological response invoked by paracrine signals from iron-starved astrocytes.	Iron	130-134	solute carrier family 9 member A9	Homo sapiens	25-29
28130443-7	2017	Ectopic expression of NHE9 in hBMVECs without external cues induced up-regulation of the transferrin receptor (TfR) and down-regulation of ferritin, leading to an increase in iron uptake.	Iron	175-179	solute carrier family 9 member A9	Homo sapiens	22-26
28270217-1	2017	BACKGROUND: Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum.	Iron	146-150	solute carrier family 11 member 2	Homo sapiens	91-119
28270217-1	2017	BACKGROUND: Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum.	Iron	146-150	solute carrier family 11 member 2	Homo sapiens	121-125
28229980-2	2017	Hepcidin-mediated inhibition of iron absorption in the duodenum is a potential mechanism.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
28229980-11	2017	CONCLUSION: Acupuncture-based weight loss can enhance the therapeutic effects of iron replacement therapy for obesity-related ID/IDA through improving intestinal iron absorption, probably by downregulating the systemic leptin-hepcidin levels.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	226-234
27848180-9	2017	Gene mutation analysis of the iron metabolism-related genes in 27 cases of iron overload with unknown etiology revealed mutations in the gene coding hemojuvelin, transferrin receptor 2, and ferroportin; this indicates that although rare, hereditary hemochromatosis does occur in Japan.	Iron	30-34	hemojuvelin BMP co-receptor	Homo sapiens	149-160
27848180-9	2017	Gene mutation analysis of the iron metabolism-related genes in 27 cases of iron overload with unknown etiology revealed mutations in the gene coding hemojuvelin, transferrin receptor 2, and ferroportin; this indicates that although rare, hereditary hemochromatosis does occur in Japan.	Iron	30-34	transferrin receptor 2	Homo sapiens	162-184
27848180-9	2017	Gene mutation analysis of the iron metabolism-related genes in 27 cases of iron overload with unknown etiology revealed mutations in the gene coding hemojuvelin, transferrin receptor 2, and ferroportin; this indicates that although rare, hereditary hemochromatosis does occur in Japan.	Iron	75-79	hemojuvelin BMP co-receptor	Homo sapiens	149-160
27848180-9	2017	Gene mutation analysis of the iron metabolism-related genes in 27 cases of iron overload with unknown etiology revealed mutations in the gene coding hemojuvelin, transferrin receptor 2, and ferroportin; this indicates that although rare, hereditary hemochromatosis does occur in Japan.	Iron	75-79	transferrin receptor 2	Homo sapiens	162-184
28511389-5	2017	AIM: Our objective was to access the Iron status of SCA patients and to find its correlation with various parameters like red cell transfusion, haemolysis and serum hepcidin.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	165-173
28140480-2	2017	Hepcidin is a recently discovered acute-phase protein (APP) that plays an important role in iron metabolism and contributes to the development of anemia in humans with CKD.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	0-8
28276324-10	2017	In these cases, presentation with arthralgia in young adulthood, low hepcidin/ferritin ratio and/or liver iron content &gt; 100 mumol/g form an indication for analysis of the TFR2 gene.	Iron	106-110	transferrin receptor 2	Homo sapiens	175-179
28120985-1	2017	A new iron(iii)-centred ferric wheel Fe {Fe6} of the formula [Fe7(H2L)6(NCS)6](ClO4)3 10H2O, where H4L = N,N"-bis(3-carboxylsalicylidene)-1,3-bis(3-aminopropyl)tetramethyldisiloxane, was synthesised and fully characterised.	Iron	6-10	cytosolic thiouridylase subunit 1	Homo sapiens	72-77
28178521-3	2017	By doing so, they form a docking site for Fe-S proteins that is disrupted in the absence of either MMS19 or MIP18.	Iron	42-46	cytosolic iron-sulfur assembly component 2B	Homo sapiens	108-113
27883199-2	2017	Measurement of hepcidin as an index of iron status shows promise, but its diagnostic performance where hemoglobinopathies are prevalent is unclear.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	15-23
27883199-10	2017	Hepcidin pre-screening would prevent most iron-replete thalassemia carriers from receiving iron whilst still ensuring most iron deficient children were supplemented.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
27883199-10	2017	Hepcidin pre-screening would prevent most iron-replete thalassemia carriers from receiving iron whilst still ensuring most iron deficient children were supplemented.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
27883199-10	2017	Hepcidin pre-screening would prevent most iron-replete thalassemia carriers from receiving iron whilst still ensuring most iron deficient children were supplemented.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
27883199-11	2017	Our data indicate that the physiological relationship between hepcidin and iron status transcends specific populations.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	62-70
27883199-12	2017	Measurement of hepcidin in individuals or populations could establish the need for iron interventions.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	15-23
27903581-4	2017	In the present study, we assessed the contribution of the metal-ion transporters ZRT/IRT-like protein 14 and 8 (ZIP14 and ZIP8) and divalent metal-ion transporter-1 (DMT1) to iron uptake by human beta-cells.	Iron	175-179	solute carrier family 11 member 2	Homo sapiens	166-170
28132948-2	2017	Hepcidin controls the iron fluxes in order to maintain sufficient iron levels for erythropoietic activities, hemoproteins synthesis or enzymes function, but also to limit its toxic accumulation throughout the body.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
28132948-2	2017	Hepcidin controls the iron fluxes in order to maintain sufficient iron levels for erythropoietic activities, hemoproteins synthesis or enzymes function, but also to limit its toxic accumulation throughout the body.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
28132948-3	2017	Hepcidin expression is regulated by various stimuli: inflammation and iron stimulate the production of the peptide, while anemia, erythropoiesis and hypoxia repress its production.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
28140621-1	2017	Lactoferrin (LF) is an iron-binding basic glycoprotein that has an antimicrobial effect against certain microbes.	Iron	23-27	lactotransferrin	Bos taurus	0-11
28140621-1	2017	Lactoferrin (LF) is an iron-binding basic glycoprotein that has an antimicrobial effect against certain microbes.	Iron	23-27	lactotransferrin	Bos taurus	13-15
28007574-4	2017	Our results suggest that Slt2 form iron/sulphur bridged clusters with Grx3 and Grx4.	Iron	35-39	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	25-29
28007574-6	2017	One of the ligands of Slt2 is required for its dimerisation upon oxidative treatment and iron repletion.	Iron	89-93	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	22-26
27864295-1	2017	Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance.	Iron	152-156	bone morphogenetic protein 6	Mus musculus	0-28
27864295-1	2017	Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance.	Iron	152-156	bone morphogenetic protein 6	Mus musculus	30-34
27864295-2	2017	How iron levels are sensed to regulate hepcidin production is not known, but local induction of liver BMP6 expression by iron is proposed to have a critical role.	Iron	121-125	bone morphogenetic protein 6	Mus musculus	102-106
27864295-3	2017	To identify the cellular source of BMP6 responsible for hepcidin and iron homeostasis regulation, we generated mice with tissue-specific ablation of Bmp6 in different liver cell populations and evaluated their iron phenotype.	Iron	69-73	bone morphogenetic protein 6	Mus musculus	35-39
27864295-9	2017	Together, these data demonstrate that ECs are the predominant source of BMP6 in the liver and support a model in which EC BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin transcription and maintain systemic iron homeostasis.	Iron	232-236	bone morphogenetic protein 6	Mus musculus	122-126
28001042-0	2017	Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.	Iron	120-124	ferredoxin 2	Homo sapiens	58-62
28001042-9	2017	In an in vitro reaction, the reduced form of each ferredoxin was found to support Fe-S cluster assembly on ISCU; the rate of cluster assembly was faster with FDX2 than with FDX1.	Iron	82-86	ferredoxin 2	Homo sapiens	158-162
28001042-10	2017	Taken together, these results show that both FDX1 and FDX2 can function in Fe-S cluster assembly in vitro.	Iron	75-79	ferredoxin 2	Homo sapiens	54-58
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	endothelial PAS domain protein 1	Homo sapiens	208-213
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	glutaredoxin 5	Homo sapiens	215-220
28055193-1	2017	MitoNEET is an outer membrane protein whose exact function remains unclear, though a role of this protein in redox and iron sensing as well as in controlling maximum mitochondrial respiratory rates has been discussed.	Iron	119-123	CDGSH iron sulfur domain 1	Homo sapiens	0-8
28096133-0	2017	Regulation of the Iron Homeostatic Hormone Hepcidin.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	43-51
28096133-3	2017	Iron absorption is regulated by the hepatic peptide hormone hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	60-68
28096133-4	2017	Hepcidin also controls iron release from cells that recycle or store iron, thus regulating plasma iron concentrations.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
28096133-4	2017	Hepcidin also controls iron release from cells that recycle or store iron, thus regulating plasma iron concentrations.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
28096133-4	2017	Hepcidin also controls iron release from cells that recycle or store iron, thus regulating plasma iron concentrations.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
28096133-5	2017	Hepcidin exerts its effects through its receptor, the cellular iron exporter ferroportin.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
28096133-6	2017	Important regulators of hepcidin, and therefore of systemic iron homeostasis, include plasma iron concentrations, body iron stores, infection and inflammation, and erythropoiesis.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	24-32
28096133-6	2017	Important regulators of hepcidin, and therefore of systemic iron homeostasis, include plasma iron concentrations, body iron stores, infection and inflammation, and erythropoiesis.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	24-32
28096133-7	2017	Disturbances in the regulation of hepcidin contribute to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and nontransfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic kidney disease, chronic inflammatory diseases, some cancers, and inherited iron-refractory iron deficiency anemia.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	34-42
28096133-7	2017	Disturbances in the regulation of hepcidin contribute to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and nontransfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic kidney disease, chronic inflammatory diseases, some cancers, and inherited iron-refractory iron deficiency anemia.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	98-106
28096133-7	2017	Disturbances in the regulation of hepcidin contribute to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and nontransfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic kidney disease, chronic inflammatory diseases, some cancers, and inherited iron-refractory iron deficiency anemia.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	34-42
28096133-7	2017	Disturbances in the regulation of hepcidin contribute to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and nontransfused beta-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic kidney disease, chronic inflammatory diseases, some cancers, and inherited iron-refractory iron deficiency anemia.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	98-106
28138322-0	2017	Iron Deposition Leads to Neuronal alpha-Synuclein Pathology by Inducing Autophagy Dysfunction.	Iron	0-4	synuclein alpha	Homo sapiens	34-49
28138322-3	2017	Using primary dopaminergic neurons and SH-SY5Y cells cultured in vitro, we observed that iron loading increased alpha-synuclein and reactive oxygen species (ROS) levels in these cells but did not affect the intracellular alpha-synuclein mRNA levels.	Iron	89-93	synuclein alpha	Homo sapiens	112-127
27855289-1	2017	OBJECTIVES: Hepcidin-25 serves as a key peptide in the regulation of iron homeostasis and inflammation.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	12-20
27870532-4	2017	This contribution reports density functional calculations to model the structures, vibrations, and Heisenberg coupling constants (J) for high-spin (HS), broken symmetry (BS) singlet, and extended broken symmetry (EBS) singlet states of the oxidized iron-sulfur cluster from mitoNEET.	Iron	249-253	CDGSH iron sulfur domain 1	Homo sapiens	274-282
27870532-5	2017	This work suggests that J values or 15 N isotopic frequency shifts may provide methods for determining experimentally whether the histidine ligand to the oxidized iron-sulfur cluster in human mitoNEET and mitoNEET-related proteins is protonated or deprotonated.	Iron	163-167	CDGSH iron sulfur domain 1	Homo sapiens	192-200
27870532-5	2017	This work suggests that J values or 15 N isotopic frequency shifts may provide methods for determining experimentally whether the histidine ligand to the oxidized iron-sulfur cluster in human mitoNEET and mitoNEET-related proteins is protonated or deprotonated.	Iron	163-167	CDGSH iron sulfur domain 1	Homo sapiens	205-213
29127682-2	2017	Because HBB protein is a critical component (along with alpha-globin, heme, and iron) of hemoglobin, the molecule essential for oxygen delivery to tissues, mutations in HBB can result in lethal diseases or diseases with multi-organ dysfunction.	Iron	80-84	hemoglobin subunit beta	Homo sapiens	8-11
29127682-2	2017	Because HBB protein is a critical component (along with alpha-globin, heme, and iron) of hemoglobin, the molecule essential for oxygen delivery to tissues, mutations in HBB can result in lethal diseases or diseases with multi-organ dysfunction.	Iron	80-84	hemoglobin subunit beta	Homo sapiens	169-172
27797162-0	2017	Fe-Doped CoP Nanoarray: A Monolithic Multifunctional Catalyst for Highly Efficient Hydrogen Generation.	Iron	0-2	caspase recruitment domain family member 16	Homo sapiens	9-12
27797162-1	2017	An Fe-doped CoP nanoarray behaves as a robust 3D monolithic multifunctional catalyst for electrolytic and hydrolytic hydrogen evolution with high activity.	Iron	3-5	caspase recruitment domain family member 16	Homo sapiens	12-15
29268258-0	2017	Clinical Implications of New Insights into Hepcidin-Mediated Regulation of Iron Absorption and Metabolism.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	43-51
29268258-3	2017	By switching off ferroportin in enterocytes and macrophages, hepcidin exerts fine control over both iron absorption and its distribution among tissues.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	61-69
29268258-4	2017	Hepcidin expression is downregulated by low iron status and active erythropoiesis and upregulated by iron overload and infection and/or inflammation.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
29268258-4	2017	Hepcidin expression is downregulated by low iron status and active erythropoiesis and upregulated by iron overload and infection and/or inflammation.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	0-8
29268258-6	2017	Pharmaceutical companies are actively developing hepcidin agonists and antagonists to combat iron overload and anemia, respectively.	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	49-57
28270080-6	2017	This review provides a comprehensive overview of various metal complexes (gold, platinum, ruthenium, rhodium, iridium, iron, palladium, silver, antimony, bismuth, tin) targeting mammalian TrxR and discusses their cytotoxicity in tumor cells.	Iron	119-123	peroxiredoxin 5	Homo sapiens	188-192
27272717-2	2017	Ceruloplasmin, a multi-copper oxidase, is mainly involved in iron metabolism and its genetic defect, aceruloplasminemia (ACP), shows neurological disorders and diabetes associated with excessive iron accumulation, but little is known about the state of copper in the brain.	Iron	61-65	ceruloplasmin	Homo sapiens	0-13
27272717-2	2017	Ceruloplasmin, a multi-copper oxidase, is mainly involved in iron metabolism and its genetic defect, aceruloplasminemia (ACP), shows neurological disorders and diabetes associated with excessive iron accumulation, but little is known about the state of copper in the brain.	Iron	195-199	ceruloplasmin	Homo sapiens	0-13
28503569-7	2017	These results indicate that TNFRI-Fc and hHO-1 overexpression may apparently induce free iron in the liver and exert oxidative stress by enhancing reactive oxygen species production and block normal postneonatal liver metabolism.	Iron	89-93	TNF receptor superfamily member 1A	Homo sapiens	28-33
28503569-7	2017	These results indicate that TNFRI-Fc and hHO-1 overexpression may apparently induce free iron in the liver and exert oxidative stress by enhancing reactive oxygen species production and block normal postneonatal liver metabolism.	Iron	89-93	heme oxygenase 1	Homo sapiens	41-46
28302014-5	2017	Decreased hepcidin enhances iron absorption and efflux.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	10-18
28302014-6	2017	Hepcidin could be predictive of iron status and the response to iron supplementation or erythropoietin-stimulating agents.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
28302014-6	2017	Hepcidin could be predictive of iron status and the response to iron supplementation or erythropoietin-stimulating agents.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
28302014-11	2017	Besides its role in anemia, recent evidence suggests that hepcidin-25 plays a role in the pathogenesis and progression of kidney injury via modulation of iron-mediated oxidant injury.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	58-66
28808355-6	2017	FE MCSF rose significantly since CKD stages 1-2, FE neopterin since CKD stages 3-5.	Iron	0-2	colony stimulating factor 1	Homo sapiens	3-7
27440164-1	2017	OBJECTIVE: The hemojuvelin-bone morphogenetic protein axis is the principal iron-dependent mechanism of hepcidin regulation.	Iron	76-80	hemojuvelin BMP co-receptor	Homo sapiens	15-26
27440164-1	2017	OBJECTIVE: The hemojuvelin-bone morphogenetic protein axis is the principal iron-dependent mechanism of hepcidin regulation.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	104-112
27908781-3	2017	To elucidate the mechanisms involved, here we assess whether the HO-1 downstream metabolites biliverdin (BV) and/or iron mediate the HO-1 antiviral effect.	Iron	116-120	heme oxygenase 1	Homo sapiens	133-137
28731447-2	2017	The neurotoxicity of alpha-Syn is enhanced by iron (Fe) and other pro-oxidant metals, leading to generation of reactive oxygen species in PD brain.	Iron	46-50	synuclein alpha	Homo sapiens	21-30
28731447-2	2017	The neurotoxicity of alpha-Syn is enhanced by iron (Fe) and other pro-oxidant metals, leading to generation of reactive oxygen species in PD brain.	Iron	52-54	synuclein alpha	Homo sapiens	21-30
28731447-6	2017	Moderate (~2-fold) increase in alpha-Syn expression in neural lineage progenitor cells (NPC) derived from induced pluripotent human stem cells (iPSCs) or differentiated SHSY-5Y cells caused DNA strand breaks in the nuclear genome, which was further enhanced synergistically by Fe salts.	Iron	277-279	synuclein alpha	Homo sapiens	31-40
28731447-9	2017	Consistent with this finding, a marked increase in Fe-dependent DNA breaks was observed in NPCs from a PD patient-derived iPSC line harboring triplication of the SNCA gene.	Iron	51-53	synuclein alpha	Homo sapiens	162-166
28550267-3	2017	Amyloid precursor protein (APP) promotes neuronal iron export.	Iron	50-54	amyloid beta (A4) precursor protein	Mus musculus	0-25
28286378-6	2017	Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages.	Iron	0-4	inositol-3-phosphate synthase 1	Homo sapiens	73-77
28286378-7	2017	Immunofluorescence analysis showed that iron also reduced iNOS production.	Iron	40-44	inositol-3-phosphate synthase 1	Homo sapiens	58-62
28286378-9	2017	Moreover, we demonstrated that STAT1 inhibition was required for reduction of iNOS and M1-related cytokines production by the present of iron.	Iron	137-141	inositol-3-phosphate synthase 1	Homo sapiens	78-82
28882209-1	2017	MitoNEET is the first identified Fe-S protein anchored to mammalian outer mitochondrial membranes with the vast majority of the protein polypeptide located in the cytosol, including its [2Fe-2S] cluster-binding domain.	Iron	33-37	CDGSH iron sulfur domain 1	Homo sapiens	0-8
28882209-5	2017	Recently, we identified cytosolic aconitase/iron regulatory protein 1 (IRP1) as the first physiological protein acceptor of the mitoNEET Fe-S cluster in an Fe-S repair process.	Iron	137-141	CDGSH iron sulfur domain 1	Homo sapiens	128-136
28882209-5	2017	Recently, we identified cytosolic aconitase/iron regulatory protein 1 (IRP1) as the first physiological protein acceptor of the mitoNEET Fe-S cluster in an Fe-S repair process.	Iron	156-160	CDGSH iron sulfur domain 1	Homo sapiens	128-136
28882209-6	2017	This chapter describes methods to study in vitro mitoNEET Fe-S cluster transfer/repair to a bacterial ferredoxin used as a model aporeceptor and in a more comprehensive manner to cytosolic aconitase/IRP1 after a nitrosative stress using in vitro, in cellulo, and in vivo methods.	Iron	58-62	CDGSH iron sulfur domain 1	Homo sapiens	49-57
28601871-1	2017	BACKGROUND: Hepcidin, an iron-regulatory hormone, plays a key role in preventing iron overload.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	12-20
28601871-2	2017	Few studies have investigated the regulation of hepcidin in low-birth-weight (LBW) infants who are vulnerable to iron imbalance.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	48-56
28704831-2	2017	Due to the short life span of reticulocytes, Ret-He reflects current iron availability for erythropoiesis more accurately than other common erythrocyte indices.	Iron	69-73	ret proto-oncogene	Homo sapiens	45-48
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	126-130	glutathione S-transferase pi 1	Homo sapiens	53-81
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	126-130	glutathione S-transferase pi 1	Homo sapiens	83-88
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	glutathione S-transferase pi 1	Homo sapiens	53-81
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	glutathione S-transferase pi 1	Homo sapiens	83-88
27991585-0	2016	Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.	Iron	40-44	ceruloplasmin	Mus musculus	15-28
27643674-2	2016	This disease is characterized by microcytic, hypochromic anemia and serum hepcidin values that are inappropriately high for body iron levels.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	74-82
27859051-0	2016	Cytosolic iron-sulfur cluster transfer-a proposed kinetic pathway for reconstitution of glutaredoxin 3.	Iron	10-14	glutaredoxin 3	Homo sapiens	88-102
27859051-4	2016	One such protein, glutaredoxin 3 (Grx3), is involved in iron regulation, sensing, and mediating [2Fe-2S] cluster delivery to cytosolic protein targets, but the cluster donor for cytosolic Grx3 has not been elucidated.	Iron	56-60	glutaredoxin 3	Homo sapiens	18-32
27859051-4	2016	One such protein, glutaredoxin 3 (Grx3), is involved in iron regulation, sensing, and mediating [2Fe-2S] cluster delivery to cytosolic protein targets, but the cluster donor for cytosolic Grx3 has not been elucidated.	Iron	56-60	glutaredoxin 3	Homo sapiens	34-38
27818378-1	2016	In plants, two genes encode ferrochelatase (FC), which catalyzes iron chelation into protoporphyrin IX at the final step of heme biosynthesis.	Iron	65-69	ferrochelatase-1, chloroplastic-like	Nicotiana tabacum	28-42
27818378-1	2016	In plants, two genes encode ferrochelatase (FC), which catalyzes iron chelation into protoporphyrin IX at the final step of heme biosynthesis.	Iron	65-69	ferrochelatase-1, chloroplastic-like	Nicotiana tabacum	44-46
27681840-1	2016	Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	0-28
27681840-1	2016	Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	30-34
27681840-1	2016	Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome.	Iron	133-137	solute carrier family 11 member 2	Homo sapiens	0-28
27681840-1	2016	Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome.	Iron	133-137	solute carrier family 11 member 2	Homo sapiens	30-34
27681840-8	2016	Among kinase inhibitors that affected DMT1-mediated iron uptake, staurosporine also reduced DMT1 phosphorylation confirming a role for serine phosphorylation in iron transport regulation.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	38-42
27846281-1	2016	Serum hepcidin concentration is regulated by iron status, inflammation, erythropoiesis and numerous other factors, but underlying processes are incompletely understood.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	6-14
27431019-11	2016	R 2 and serum ferritin had the highest diagnostic accuracies to detect elevated R 2* as mark of iron overload.	Iron	96-100	ribonucleotide reductase regulatory subunit M2	Homo sapiens	0-3
27431019-11	2016	R 2 and serum ferritin had the highest diagnostic accuracies to detect elevated R 2* as mark of iron overload.	Iron	96-100	ribonucleotide reductase regulatory subunit M2	Homo sapiens	80-83
27498774-11	2016	Additionally, another specific AChE inhibitor, donepezil (Don), at a concentration that caused AChE inhibition equivalent to that of HupA negatively, influenced the aberrant changes in ROS, ATP or LIP that were induced by excessive iron.	Iron	232-236	acetylcholinesterase	Rattus norvegicus	31-35
27890361-3	2016	The cellular iron balance in humans is primarily mediated by the hepcidin-ferroportin axis.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	65-73
27890361-5	2016	Hepcidin, a hormone produced by liver cells, post-translationally regulates ferroportin expression on iron exporting cells by binding with ferroportin and promoting its internalization by endocytosis and subsequent degradation by lysosomes.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	0-8
27890361-8	2016	Beta-thalassemia is common in the Mediterranean region, Southeast Asia and the Indian subcontinent, and the focus of this review is to provide an update on the factors mediating hepcidin related iron dysregulation in beta-thalassemia disease.	Iron	195-199	hepcidin antimicrobial peptide	Homo sapiens	178-186
27571925-5	2016	Iron, one of HO-1 catalytic products, was an important mediator in this regulation.	Iron	0-4	heme oxygenase 1	Homo sapiens	13-17
27550424-2	2016	Recently, Fe(HPNP)(CO)(H)(HBH3) (cp1) and Fe(HPNP)(CO)(H)(Br) (cp2), the iron(ii) complexes supported by bis(phosphino)amine pincer (Fe-PNP) (PNP = N(CH2CH2P(i)Pr2)2), have been reported to be the starting complexes which can catalyze the dehydrogenation and hydrogenation of N-heterocycles.	Iron	73-77	ceruloplasmin	Homo sapiens	63-66
27676264-4	2016	Density functional theory calculations further reveal that Fe substitution of Co in CoP leads to more optimal free energy of hydrogen adsorption to the catalyst surface.	Iron	59-61	caspase recruitment domain family member 16	Homo sapiens	84-87
28262197-2	2016	Few studies have examined the role of hepcidin on maternal iron homeostasis in the context of obese pregnancy.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	38-46
28262197-10	2016	The smallest hepcidin decline occurred in iron-supplemented Ob women compared to non-supplemented Lc women (p = 0.022).	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	13-21
28262197-11	2016	The risk for iron deficiency at the end of pregnancy was higher for Ob than for Lc (OR = 4.45, 95% CI = 2.07-9.58) after adjusting for iron supplementation and hepcidin concentration.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	160-168
27667164-1	2016	Hepcidin is the key regulator of systemic iron homeostasis.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
27667164-2	2016	The iron-sensing mechanisms and the role of intracellular iron in modulating hepatic hepcidin secretion are unclear.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	85-93
27483343-3	2016	In this study we asked whether hepcidin response to ER stress also requires the small mother against decapentaplegic (SMAD)-1/5/8 pathway, which has a major role in hepcidin regulation in response to iron and other stimuli.	Iron	200-204	SMAD family member 1	Mus musculus	80-127
27380194-0	2016	Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase.	Iron	0-4	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	104-128
27380194-7	2016	We hypothesized that iron itself activates the ACO1-IDH pathway, which may increase 2-HG and DNA methylation, and eventually contribute to leukemogenesis without IDH mutation.	Iron	21-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	52-55
27380194-7	2016	We hypothesized that iron itself activates the ACO1-IDH pathway, which may increase 2-HG and DNA methylation, and eventually contribute to leukemogenesis without IDH mutation.	Iron	21-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	162-165
27380194-8	2016	Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, we observed that the enzymes, phosphoglucomutase 1, glycogen debranching enzyme, and isocitrate dehydrogenase 1 (Idh1), which are involved in glycogen and glucose metabolism, were increased.	Iron	51-55	phosphoglucomutase 2	Mus musculus	103-123
27380194-8	2016	Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, we observed that the enzymes, phosphoglucomutase 1, glycogen debranching enzyme, and isocitrate dehydrogenase 1 (Idh1), which are involved in glycogen and glucose metabolism, were increased.	Iron	51-55	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	158-184
27380194-8	2016	Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, we observed that the enzymes, phosphoglucomutase 1, glycogen debranching enzyme, and isocitrate dehydrogenase 1 (Idh1), which are involved in glycogen and glucose metabolism, were increased.	Iron	51-55	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	186-190
26545340-3	2016	Indeed, many proteins initially characterized in those diseases such as amyloid-beta protein, alpha-synuclein, and huntingtin have been linked to iron neurochemistry.	Iron	146-150	synuclein alpha	Homo sapiens	94-109
27569531-2	2016	In the absence of PspA Streptococcus pneumoniae becomes more susceptible to killing by human apolactoferrin (apo-hLf), the iron-free form of lactoferrin.	Iron	123-127	HLF transcription factor, PAR bZIP family member	Homo sapiens	113-116
27714045-3	2016	The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins, and, in mammals, it relies on the activity of a multiprotein transfer complex that contains the chaperone HSPA9, the co-chaperone HSC20 and the scaffold ISCU.	Iron	26-30	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	246-251
27714045-3	2016	The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins, and, in mammals, it relies on the activity of a multiprotein transfer complex that contains the chaperone HSPA9, the co-chaperone HSC20 and the scaffold ISCU.	Iron	101-105	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	246-251
27714045-5	2016	This mini review focuses on recent insights into the molecular mechanism of amino acid motif recognition and discrimination by the co-chaperone HSC20, which guides Fe-S cluster delivery.	Iron	164-168	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	144-149
27557498-6	2016	We then identified ribonucleotide reductase M2 (RRM2), the iron-dependent subunit of ribonucleotide reductase (RNR), as one mediator of iron chelator toxicity in Ewing sarcoma cells.	Iron	59-63	ribonucleotide reductase regulatory subunit M2	Homo sapiens	19-46
27557498-6	2016	We then identified ribonucleotide reductase M2 (RRM2), the iron-dependent subunit of ribonucleotide reductase (RNR), as one mediator of iron chelator toxicity in Ewing sarcoma cells.	Iron	59-63	ribonucleotide reductase regulatory subunit M2	Homo sapiens	48-52
27557498-6	2016	We then identified ribonucleotide reductase M2 (RRM2), the iron-dependent subunit of ribonucleotide reductase (RNR), as one mediator of iron chelator toxicity in Ewing sarcoma cells.	Iron	136-140	ribonucleotide reductase regulatory subunit M2	Homo sapiens	19-46
27557498-6	2016	We then identified ribonucleotide reductase M2 (RRM2), the iron-dependent subunit of ribonucleotide reductase (RNR), as one mediator of iron chelator toxicity in Ewing sarcoma cells.	Iron	136-140	ribonucleotide reductase regulatory subunit M2	Homo sapiens	48-52
27646472-0	2016	Activation of ATP-sensitive potassium channels enhances DMT1-mediated iron uptake in SK-N-SH cells in vitro.	Iron	70-74	solute carrier family 11 member 2	Homo sapiens	56-60
27646472-1	2016	Iron importer divalent metal transporter 1 (DMT1) plays a crucial role in the nigal iron accumulation in Parkinson"s disease (PD).	Iron	84-88	solute carrier family 11 member 2	Homo sapiens	14-42
27646472-1	2016	Iron importer divalent metal transporter 1 (DMT1) plays a crucial role in the nigal iron accumulation in Parkinson"s disease (PD).	Iron	84-88	solute carrier family 11 member 2	Homo sapiens	44-48
27646472-5	2016	Therefore, it is of vital importance to study the effects of activation of KATP channels on DMT1-mediated iron uptake function.	Iron	106-110	solute carrier family 11 member 2	Homo sapiens	92-96
27646472-6	2016	In the present study, activation of KATP channels by diazoxide resulted in the hyperpolarization of the membrane potential and increased DMT1-mediated iron uptake in SK-N-SH cells.	Iron	151-155	solute carrier family 11 member 2	Homo sapiens	137-141
27646472-8	2016	Delayed inactivation of the Fe(2+)-evoked currents by diazoxide was recorded by patch clamp in HEK293 cells, which demonstrated that diazoxide could prolonged DMT1-facilitated iron transport.	Iron	176-180	solute carrier family 11 member 2	Homo sapiens	159-163
27445333-5	2016	Non-mutagenic chemical ribosomal inactivation disrupted iron homeostasis by regulating expression of the iron exporter FPN-1, leading to intracellular accumulation in enterocytes.	Iron	56-60	solute carrier family 40 member 1	Homo sapiens	119-124
27445333-5	2016	Non-mutagenic chemical ribosomal inactivation disrupted iron homeostasis by regulating expression of the iron exporter FPN-1, leading to intracellular accumulation in enterocytes.	Iron	105-109	solute carrier family 40 member 1	Homo sapiens	119-124
27625068-1	2016	Mitochondrial ferritin (FtMt) is an iron storage protein belonging to the ferritin family but, unlike the cytosolic ferritin, it has an iron-unrelated restricted tissue expression.	Iron	36-40	ferritin mitochondrial	Homo sapiens	0-22
27625068-1	2016	Mitochondrial ferritin (FtMt) is an iron storage protein belonging to the ferritin family but, unlike the cytosolic ferritin, it has an iron-unrelated restricted tissue expression.	Iron	36-40	ferritin mitochondrial	Homo sapiens	24-28
27625068-1	2016	Mitochondrial ferritin (FtMt) is an iron storage protein belonging to the ferritin family but, unlike the cytosolic ferritin, it has an iron-unrelated restricted tissue expression.	Iron	136-140	ferritin mitochondrial	Homo sapiens	0-22
27625068-1	2016	Mitochondrial ferritin (FtMt) is an iron storage protein belonging to the ferritin family but, unlike the cytosolic ferritin, it has an iron-unrelated restricted tissue expression.	Iron	136-140	ferritin mitochondrial	Homo sapiens	24-28
27625068-2	2016	FtMt appears to be preferentially expressed in cell types characterized by high metabolic activity and oxygen consumption, suggesting a role in protecting mitochondria from iron-dependent oxidative damage.	Iron	173-177	ferritin mitochondrial	Homo sapiens	0-4
27679642-7	2016	Over-expressed BnMEB2 in both Arabidopsis wild type and meb2 mutant seedlings resulted in greatly improved iron tolerability with no significant changes in the expression level of other VIT genes.	Iron	107-111	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	56-60
27679642-8	2016	The mutant meb2 grew slowly and its root hair elongation was inhibited under high iron concentration condition while BnMEB2 over-expressed transgenic plants of the mutant restored the phenotypes with apparently higher iron storage in roots and dramatically increased iron content in the whole plant.	Iron	82-86	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	11-15
27679642-8	2016	The mutant meb2 grew slowly and its root hair elongation was inhibited under high iron concentration condition while BnMEB2 over-expressed transgenic plants of the mutant restored the phenotypes with apparently higher iron storage in roots and dramatically increased iron content in the whole plant.	Iron	218-222	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	11-15
27679642-8	2016	The mutant meb2 grew slowly and its root hair elongation was inhibited under high iron concentration condition while BnMEB2 over-expressed transgenic plants of the mutant restored the phenotypes with apparently higher iron storage in roots and dramatically increased iron content in the whole plant.	Iron	218-222	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	11-15
27598194-0	2016	Hepcidin is a Better Predictor of Iron Stores in Premenopausal Women than Blood Loss or Dietary Intake.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
27598194-1	2016	The relationship between dietary intake, circulating hepcidin and iron status in free-living premenopausal women has not been explored.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	53-61
27598194-8	2016	Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R2 of model including hepcidin = 0.65; R2 of model excluding hepcidin = 0.17, p for difference &lt;0.001), and increased hepcidin diminished the positive association between iron intake and iron stores.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
27287253-12	2016	Iron overload in mice was associated with elevated ferritin and decreased Runx2 mRNA levels in compact bone osteoprogenitor cells.	Iron	0-4	runt related transcription factor 2	Mus musculus	74-79
27323763-2	2016	In this study, epigallocatechin gallate (EGCG) and soybean seed ferritin deprived of iron (apoSSF) were fabricated as a combined double shell material to encapsulate rutin flavonoid molecules.	Iron	85-89	ferritin-1, chloroplastic	Glycine max	64-72
27058404-3	2016	Hepcidin modulates iron egress via ferroportin and its storage in ferritin.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	0-8
27058404-14	2016	We propose that HCV control over iron occurs both by intracellular iron sequestration, through hepcidin, and intercellular iron mobilisation via ferritin, as means toward enhanced replication.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	95-103
27302059-0	2016	Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	36-49
27302059-1	2016	Ferroportin 1 (FPN1) is an iron export protein found in mammals.	Iron	27-31	solute carrier family 40 member 1	Homo sapiens	0-13
27302059-1	2016	Ferroportin 1 (FPN1) is an iron export protein found in mammals.	Iron	27-31	solute carrier family 40 member 1	Homo sapiens	15-19
27302059-2	2016	FPN1 is important for the export of iron across the basolateral membrane of absorptive enterocytes and across the plasma membrane of macrophages.	Iron	36-40	solute carrier family 40 member 1	Homo sapiens	0-4
27302059-5	2016	Subsequently, PCBP2 receives iron from DMT1 and then disengages from the transporter.	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	39-43
27302059-9	2016	Importantly, iron-loaded, but not iron-depleted, PCBP2 interacts with FPN1.	Iron	13-17	solute carrier family 40 member 1	Homo sapiens	70-74
27302059-11	2016	The silencing of PCBP2 expression suppressed FPN1-dependent iron export from cells.	Iron	60-64	solute carrier family 40 member 1	Homo sapiens	45-49
27302059-12	2016	These results suggest that FPN1 exports iron received from the iron chaperone PCBP2.	Iron	40-44	solute carrier family 40 member 1	Homo sapiens	27-31
27288519-0	2016	JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.	Iron	72-76	Janus kinase 2	Mus musculus	0-4
27387771-0	2016	Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis.	Iron	21-25	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	98-102
27002602-8	2016	Docking indicated that the N-containing rings of OME possibly could interact with the iron atom of the heme for S-OME in CYP17A1 and S- and R-OME in CYP21A2.	Iron	86-90	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	149-156
27441659-9	2016	In addition, ferroportin-1 (FPN) is an iron transport protein, responsible for removal of iron from cells.	Iron	39-43	solute carrier family 40 member 1	Homo sapiens	13-26
27441659-9	2016	In addition, ferroportin-1 (FPN) is an iron transport protein, responsible for removal of iron from cells.	Iron	90-94	solute carrier family 40 member 1	Homo sapiens	13-26
27401861-2	2016	Atx1p plays an important role in the intracellular copper transport as a copper chaperone transferring copper from the transporters to Ccc2p for its subsequent insertion into Fet3p, which is required for high affinity iron transport.	Iron	218-222	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	0-5
26996235-6	2016	However, recent experimental assays have challenged this assumption and shown that HDAC8 is catalytically active with a variety of different metals, and that it may be a Fe-dependent enzyme in vivo.	Iron	170-172	histone deacetylase 8	Homo sapiens	83-88
27221532-3	2016	The HFE gene also affects the activity of hepcidin, a hormone which acts as a negative regulator of iron metabolism.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	42-50
27381105-6	2016	NFU1 gene is one of such genes and has a role in the assembly of iron-sulfur cluster (ISC).	Iron	65-69	NFU1 iron-sulfur cluster scaffold	Homo sapiens	0-4
27343351-4	2016	We show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2).	Iron	66-70	Myocyte enhancer factor 2	Drosophila melanogaster	209-234
27343351-4	2016	We show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2).	Iron	66-70	Myocyte enhancer factor 2	Drosophila melanogaster	236-240
27332079-3	2016	Chronic liver disease decreases the synthetic functions of the liver, including the production of hepcidin, a key protein in iron metabolism.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	98-106
27332079-4	2016	Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-transferrin-bound iron in the bloodstream.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	16-24
27332079-4	2016	Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-transferrin-bound iron in the bloodstream.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	16-24
27332079-4	2016	Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-transferrin-bound iron in the bloodstream.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	16-24
27332079-6	2016	Iron-induced cellular damage may be prevented by regulating the production of hepcidin or by administering hepcidin agonists.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	78-86
27332079-6	2016	Iron-induced cellular damage may be prevented by regulating the production of hepcidin or by administering hepcidin agonists.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	107-115
27445804-1	2016	The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
27445804-1	2016	The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	28-36
27445804-1	2016	The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	28-36
27445804-2	2016	Hepcidin insufficiency causes hyperabsorption of dietary iron, hyperferremia and tissue iron overload, which are hallmarks of hereditary hemochromatosis.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
27445804-2	2016	Hepcidin insufficiency causes hyperabsorption of dietary iron, hyperferremia and tissue iron overload, which are hallmarks of hereditary hemochromatosis.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	0-8
27445804-4	2016	On the other hand, excessive hepcidin expression inhibits dietary iron absorption and leads to hypoferremia and iron retention within tissue macrophages.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	29-37
27445804-4	2016	On the other hand, excessive hepcidin expression inhibits dietary iron absorption and leads to hypoferremia and iron retention within tissue macrophages.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	29-37
27445804-6	2016	Pharmacological targeting of the hepcidin/ferroportin axis may offer considerable therapeutic benefits by correcting iron traffic.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	33-41
27445804-7	2016	This review summarizes the principles underlying the development of hepcidin-based therapies for the treatment of iron-related disorders, and discusses the emerging strategies for manipulating hepcidin pathways.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	68-76
27276035-0	2016	Hepcidin Response to Iron Therapy in Patients with Non-Dialysis Dependent CKD: An Analysis of the FIND-CKD Trial.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	0-8
27276035-1	2016	Hepcidin is the key regulator of iron homeostasis but data are limited regarding its temporal response to iron therapy, and response to intravenous versus oral iron.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
27276035-1	2016	Hepcidin is the key regulator of iron homeostasis but data are limited regarding its temporal response to iron therapy, and response to intravenous versus oral iron.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
27276035-1	2016	Hepcidin is the key regulator of iron homeostasis but data are limited regarding its temporal response to iron therapy, and response to intravenous versus oral iron.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
27276035-6	2016	The increase in hepcidin from baseline was significantly smaller with low ferritin FCM or oral iron vs high ferritin FCM at all time points up to week 52.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	16-24
27276035-8	2016	The increase in hepcidin levels over the 12-month study generally mirrored the cumulative iron dose in each group.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	16-24
27276035-12	2016	In conclusion, hepcidin levels rose in response to either intravenous or oral iron therapy, but the speed and extent of the rise was greatest with intravenous iron targeting a higher ferritin level.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	15-23
27276035-12	2016	In conclusion, hepcidin levels rose in response to either intravenous or oral iron therapy, but the speed and extent of the rise was greatest with intravenous iron targeting a higher ferritin level.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	15-23
27203448-10	2016	Using quantum chemistry centered normal coordinate analysis (QCC-NCA), this is shown to arise from an increase in Fe-NO bond order and a stiffening of the Fe(NO)2 unit upon reduction of 1 to 2.	Iron	114-116	CEA cell adhesion molecule 6	Homo sapiens	65-68
27142241-5	2016	Many nuclear processes are influenced by a spatial switch involving the proteins {KPNA2, KPNB1, PCNA, PTMA, SET} and heme/iron proteins HMOX1 and FTH1.	Iron	122-126	heme oxygenase 1	Homo sapiens	136-141
27142241-5	2016	Many nuclear processes are influenced by a spatial switch involving the proteins {KPNA2, KPNB1, PCNA, PTMA, SET} and heme/iron proteins HMOX1 and FTH1.	Iron	122-126	ferritin heavy chain 1	Homo sapiens	146-150
26911670-5	2016	Under iron-loaded conditions, the activity of dietary iron absorption was clearly lowered in response to up-regulation of hepcidin, although the estimated activity of iron release from stored iron was not compared with that under control conditions.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	122-130
26911670-5	2016	Under iron-loaded conditions, the activity of dietary iron absorption was clearly lowered in response to up-regulation of hepcidin, although the estimated activity of iron release from stored iron was not compared with that under control conditions.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	122-130
26911670-5	2016	Under iron-loaded conditions, the activity of dietary iron absorption was clearly lowered in response to up-regulation of hepcidin, although the estimated activity of iron release from stored iron was not compared with that under control conditions.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	122-130
26911670-5	2016	Under iron-loaded conditions, the activity of dietary iron absorption was clearly lowered in response to up-regulation of hepcidin, although the estimated activity of iron release from stored iron was not compared with that under control conditions.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	122-130
26911670-6	2016	This result was supported by the observation that two duodenal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin, were downregulated by iron loading, although the levels of expression of ferroportin in iron storage tissues were not changed by iron loading under erythropoietic stimulation by epoetin-beta pegol (C.E.R.A., a long-acting erythropoiesis-stimulating agent).	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	82-110
26911670-6	2016	This result was supported by the observation that two duodenal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin, were downregulated by iron loading, although the levels of expression of ferroportin in iron storage tissues were not changed by iron loading under erythropoietic stimulation by epoetin-beta pegol (C.E.R.A., a long-acting erythropoiesis-stimulating agent).	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	112-116
26911670-6	2016	This result was supported by the observation that two duodenal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin, were downregulated by iron loading, although the levels of expression of ferroportin in iron storage tissues were not changed by iron loading under erythropoietic stimulation by epoetin-beta pegol (C.E.R.A., a long-acting erythropoiesis-stimulating agent).	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	82-110
26911670-6	2016	This result was supported by the observation that two duodenal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin, were downregulated by iron loading, although the levels of expression of ferroportin in iron storage tissues were not changed by iron loading under erythropoietic stimulation by epoetin-beta pegol (C.E.R.A., a long-acting erythropoiesis-stimulating agent).	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	112-116
26911670-6	2016	This result was supported by the observation that two duodenal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin, were downregulated by iron loading, although the levels of expression of ferroportin in iron storage tissues were not changed by iron loading under erythropoietic stimulation by epoetin-beta pegol (C.E.R.A., a long-acting erythropoiesis-stimulating agent).	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	82-110
26911670-6	2016	This result was supported by the observation that two duodenal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin, were downregulated by iron loading, although the levels of expression of ferroportin in iron storage tissues were not changed by iron loading under erythropoietic stimulation by epoetin-beta pegol (C.E.R.A., a long-acting erythropoiesis-stimulating agent).	Iron	157-161	solute carrier family 11 member 2	Homo sapiens	112-116
26996132-6	2016	Interestingly, we found that DFO up-regulated the expression of HIF-1alpha protein, TH, vascular endothelial growth factor (VEGF), and growth associated protein 43 (GAP43) and down-regulated the expression of alpha-synuclein, divalent metal transporter with iron-responsive element (DMT1+IRE), and transferrin receptor (TFR).	Iron	258-262	synuclein, alpha	Mus musculus	209-224
27234407-4	2016	Lactoferrin is a 77 kDa, iron-binding glycoprotein that is present at high concentration in human milk compared with bovine milk and infant formula.	Iron	25-29	lactotransferrin	Bos taurus	0-11
27129288-5	2016	Further analyses revealed that NET induction by iron chelation required NADPH-dependent production of reactive oxygen species (ROS) as well as protease and peptidyl-arginine-deiminase 4 (PAD4) activities, three key mechanistic pathways previously linked to NET formation.	Iron	48-52	peptidyl arginine deiminase 4	Homo sapiens	156-185
26808248-0	2016	Treatment of acid rock drainage using a sulfate-reducing bioreactor with zero-valent iron.	Iron	85-89	acireductone dioxygenase 1	Homo sapiens	13-31
26808248-1	2016	This study assessed the bioremediation of acid rock drainage (ARD) in flow-through columns testing zero-valent iron (ZVI) for the first time as the sole exogenous electron donor to drive sulfate-reducing bacteria in permeable reactive barriers.	Iron	111-115	acireductone dioxygenase 1	Homo sapiens	42-60
26808248-1	2016	This study assessed the bioremediation of acid rock drainage (ARD) in flow-through columns testing zero-valent iron (ZVI) for the first time as the sole exogenous electron donor to drive sulfate-reducing bacteria in permeable reactive barriers.	Iron	117-120	acireductone dioxygenase 1	Homo sapiens	42-60
27142428-8	2016	Satellite cells and IBA1-reactive monocytes displayed upregulated ferritin biosynthesis, which was most likely due to leakage of iron from dying neurons.	Iron	129-133	allograft inflammatory factor 1	Homo sapiens	20-24
26960903-1	2016	In response to the need for straightforward analytical methods to assess the affinity of molecularly imprinted nanoparticles (MIP NPs) for ligands, capillary electrophoresis (CE) was exploited using MIP NPs targeting the iron-regulating hormone hepcidin.	Iron	221-225	hepcidin antimicrobial peptide	Homo sapiens	245-253
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	73-81
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	236-244
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	236-244
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	236-244
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	287-291	hepcidin antimicrobial peptide	Homo sapiens	236-244
26990350-5	2016	The data suggested that liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia and, eventually, to a hyporesponse/resistance to rHuEPO therapy.	Iron	287-291	hepcidin antimicrobial peptide	Homo sapiens	236-244
26827808-5	2016	Iron depletion increased expression of iron-regulated proteins (TfR, transferrin receptor and DMT1, divalent metal transporter, as predicted, but it also promoted a marked reduction in growth and proliferation of Caco-2 cells.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	94-98
26827808-5	2016	Iron depletion increased expression of iron-regulated proteins (TfR, transferrin receptor and DMT1, divalent metal transporter, as predicted, but it also promoted a marked reduction in growth and proliferation of Caco-2 cells.	Iron	39-43	solute carrier family 11 member 2	Homo sapiens	94-98
26827808-8	2016	The increase in REDD1 abundance was rapidly reversed upon iron repletion of cells but was also attenuated by inhibitors of gene transcription, protein phosphatase 2A (PP2A) and by REDD1 siRNA--strategies that also antagonised the loss in mTORC1 signalling associated with iron depletion.	Iron	58-62	protein phosphatase 2 phosphatase activator	Homo sapiens	167-171
26827808-9	2016	Our findings implicate REDD1 and PP2A as crucial regulators of mTORC1 activity in iron-depleted cells and indicate that their modulation may help mitigate atrophy of the intestinal mucosa that may occur in response to iron deficiency.	Iron	82-86	protein phosphatase 2 phosphatase activator	Homo sapiens	33-37
26871253-8	2016	Iron is indispensable for heme biosynthesis in erythroblasts; a process finely coordinated by at least two hormones, hepcidin and erythroferrone, together with multiple cell surface iron transporters.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	117-125
26886082-6	2016	In certain populations, hepcidin assays may help target therapy with iron or erythropoiesis-stimulating agents to patients who may benefit most.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	24-32
26970172-7	2016	Moreover, patients with mutations presented both improper iron uptake and distribution (lower serum hepcidin-25 concentration, P=0.028) and enhanced erythropoietic activity (higher soluble transferrin receptor level, P=0.132; higher growth differentiation factor 15 concentration, P&lt;0.001).	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	100-108
26667237-3	2016	Reticulocyte hemoglobin equivalent (Ret-He) may be useful for assessing iron status.	Iron	72-76	ret proto-oncogene	Homo sapiens	0-3
26667237-8	2016	CONCLUSIONS: Ret-He is a more relevant marker of iron status than ferritin and TSAT.	Iron	49-53	ret proto-oncogene	Homo sapiens	13-16
26850578-0	2016	Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination.	Iron	13-17	lactotransferrin	Bos taurus	45-56
26850578-0	2016	Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination.	Iron	92-96	lactotransferrin	Bos taurus	45-56
26945724-0	2016	Iron depletion in HCT116 cells diminishes the upregulatory effect of phenethyl isothiocyanate on heme oxygenase-1.	Iron	0-4	heme oxygenase 1	Homo sapiens	97-113
26945724-3	2016	Herein, the objective was to ascertain if adequate iron is needed for enabling HCT116 cells to optimally express heme oxygenase-1 (HO-1) when induced by phenethyl isothiocyanate (PEITC).	Iron	51-55	heme oxygenase 1	Homo sapiens	113-129
26945724-3	2016	Herein, the objective was to ascertain if adequate iron is needed for enabling HCT116 cells to optimally express heme oxygenase-1 (HO-1) when induced by phenethyl isothiocyanate (PEITC).	Iron	51-55	heme oxygenase 1	Homo sapiens	131-135
26945724-10	2016	Collectively, the results imply that the HO-1 upregulation by PEITC involves an iron-dependent, oxidant signaling pathway.	Iron	80-84	heme oxygenase 1	Homo sapiens	41-45
26945724-11	2016	Therefore, it is concluded that ample iron is required to enable PEITC to fully upregulate HO-1 expression in HCT116 cells.	Iron	38-42	heme oxygenase 1	Homo sapiens	91-95
26374145-3	2016	Hepcidin is a key hepatic hormone regulating iron balance.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
26494833-10	2016	Mean serum hepcidin decreased significantly 4 weeks into study: by 80% in HD patients receiving no iron (n=22), 52% in HD and PD patients receiving oral iron (n=21), and 41% in HD patients receiving IV iron (n=9).	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	11-19
26494833-10	2016	Mean serum hepcidin decreased significantly 4 weeks into study: by 80% in HD patients receiving no iron (n=22), 52% in HD and PD patients receiving oral iron (n=21), and 41% in HD patients receiving IV iron (n=9).	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	11-19
26494833-10	2016	Mean serum hepcidin decreased significantly 4 weeks into study: by 80% in HD patients receiving no iron (n=22), 52% in HD and PD patients receiving oral iron (n=21), and 41% in HD patients receiving IV iron (n=9).	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	11-19
26372311-10	2016	HHT2 subjects were more likely to use oral iron (P = .032) and were more likely to seek interventions to control their epistaxis (P = .029).	Iron	43-47	activin A receptor like type 1	Homo sapiens	0-4
26842892-0	2016	Protection of scaffold protein Isu from degradation by the Lon protease Pim1 as a component of Fe-S cluster biogenesis regulation.	Iron	95-99	lon peptidase 1, mitochondrial	Homo sapiens	59-62
25833099-0	2016	alpha-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons.	Iron	50-54	synuclein alpha	Homo sapiens	0-15
25833099-0	2016	alpha-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons.	Iron	90-94	synuclein alpha	Homo sapiens	0-15
25833099-2	2016	Metal to protein binding assays have shown that alpha-synuclein can bind iron in vitro; therefore, we hypothesized that iron content and iron distribution could be modified in cellulo, in cells over-expressing alpha-synuclein.	Iron	73-77	synuclein alpha	Homo sapiens	48-63
26921305-0	2016	Two bHLH Transcription Factors, bHLH34 and bHLH104, Regulate Iron Homeostasis in Arabidopsis thaliana.	Iron	61-65	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	32-38
26921305-0	2016	Two bHLH Transcription Factors, bHLH34 and bHLH104, Regulate Iron Homeostasis in Arabidopsis thaliana.	Iron	61-65	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	43-50
26921305-3	2016	Here, we report that two basic helix-loop-helix-type transcription factors, bHLH34 and bHLH104, positively regulate Fe homeostasis in Arabidopsis (Arabidopsis thaliana).	Iron	116-118	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	76-82
26921305-3	2016	Here, we report that two basic helix-loop-helix-type transcription factors, bHLH34 and bHLH104, positively regulate Fe homeostasis in Arabidopsis (Arabidopsis thaliana).	Iron	116-118	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	87-94
26921305-4	2016	Loss of function of bHLH34 and bHLH104 causes disruption of the Fe deficiency response and the reduction of Fe content, whereas overexpression plants constitutively promote the expression of Fe deficiency-responsive genes and Fe accumulation.	Iron	64-66	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	20-26
26921305-4	2016	Loss of function of bHLH34 and bHLH104 causes disruption of the Fe deficiency response and the reduction of Fe content, whereas overexpression plants constitutively promote the expression of Fe deficiency-responsive genes and Fe accumulation.	Iron	64-66	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	31-38
26921305-4	2016	Loss of function of bHLH34 and bHLH104 causes disruption of the Fe deficiency response and the reduction of Fe content, whereas overexpression plants constitutively promote the expression of Fe deficiency-responsive genes and Fe accumulation.	Iron	108-110	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	20-26
26921305-4	2016	Loss of function of bHLH34 and bHLH104 causes disruption of the Fe deficiency response and the reduction of Fe content, whereas overexpression plants constitutively promote the expression of Fe deficiency-responsive genes and Fe accumulation.	Iron	108-110	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	31-38
26976781-6	2016	Fermented goat"s milk increased expression of duodenal Dcytb, DMT1, and FPN1 and decreased Hamp and TfR1, improving Fe metabolism during anemia recovery.	Iron	0-2	hepcidin	Capra hircus	91-95
26978524-1	2016	BACKGROUND: We aimed to identify associations between erythroferrone (ERFE), a regulator of hepcidin 25, and biomarkers of erythropoiesis and iron metabolism.	Iron	142-146	erythroferrone	Homo sapiens	70-74
26978524-11	2016	Both DA and CERA increased levels of ERFE that regulated hepcidin 25 and led to iron mobilization from body stores during erythropoiesis.	Iron	80-84	erythroferrone	Homo sapiens	37-41
26944411-4	2016	RESULTS: We confirm previous results by showing that breast cancer epithelial cells present an "iron-utilization phenotype" with an increased expression of hepcidin and TFR1, and decreased expression of FT. On the other hand, lymphocytes and macrophages infiltrating primary tumors and from metastized lymph nodes display an "iron-donor" phenotype, with increased expression of FPN1 and FT, concomitant with an activation profile reflected by a higher expression of TFR1 and hepcidin.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	156-164
26944411-4	2016	RESULTS: We confirm previous results by showing that breast cancer epithelial cells present an "iron-utilization phenotype" with an increased expression of hepcidin and TFR1, and decreased expression of FT. On the other hand, lymphocytes and macrophages infiltrating primary tumors and from metastized lymph nodes display an "iron-donor" phenotype, with increased expression of FPN1 and FT, concomitant with an activation profile reflected by a higher expression of TFR1 and hepcidin.	Iron	96-100	solute carrier family 40 member 1	Homo sapiens	378-382
26944411-4	2016	RESULTS: We confirm previous results by showing that breast cancer epithelial cells present an "iron-utilization phenotype" with an increased expression of hepcidin and TFR1, and decreased expression of FT. On the other hand, lymphocytes and macrophages infiltrating primary tumors and from metastized lymph nodes display an "iron-donor" phenotype, with increased expression of FPN1 and FT, concomitant with an activation profile reflected by a higher expression of TFR1 and hepcidin.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	475-483
26934375-1	2016	Ceruloplasmin, the main copper binding protein in blood plasma, has been of particular interest for its role in efflux of iron from cells, but has additional functions.	Iron	122-126	ceruloplasmin	Homo sapiens	0-13
26890363-6	2016	Control of iron efflux through the combined action of ferroportin, an iron efflux pump, and its regulator hepcidin appears to play an important role in tumorigenesis.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	106-114
26919168-4	2016	The master regulator of iron homeostasis, hepcidin, is chronically repressed in this disorder, leading to increased intestinal iron absorption and consequent iron overload.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	42-50
26919168-4	2016	The master regulator of iron homeostasis, hepcidin, is chronically repressed in this disorder, leading to increased intestinal iron absorption and consequent iron overload.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	42-50
26919168-4	2016	The master regulator of iron homeostasis, hepcidin, is chronically repressed in this disorder, leading to increased intestinal iron absorption and consequent iron overload.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	42-50
26886577-1	2016	Ferritin is a sub-family of iron binding proteins that form multi-subunit nanotype iron storage structures and prevent oxidative stress induced apoptosis.	Iron	28-32	ferritin heavy chain 1	Homo sapiens	0-8
26886577-1	2016	Ferritin is a sub-family of iron binding proteins that form multi-subunit nanotype iron storage structures and prevent oxidative stress induced apoptosis.	Iron	83-87	ferritin heavy chain 1	Homo sapiens	0-8
26582087-2	2016	It is caused by defective expression of liver hepcidin, the main regulator of iron homeostasis.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	46-54
26582087-3	2016	Iron stimulates the gene encoding hepcidin (HAMP) via the bone morphogenetic protein (BMP)6 signaling to SMAD.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	34-42
26582087-3	2016	Iron stimulates the gene encoding hepcidin (HAMP) via the bone morphogenetic protein (BMP)6 signaling to SMAD.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	44-48
26582087-3	2016	Iron stimulates the gene encoding hepcidin (HAMP) via the bone morphogenetic protein (BMP)6 signaling to SMAD.	Iron	0-4	bone morphogenetic protein 1	Homo sapiens	58-84
26290259-6	2016	Systemic and intracellular iron regulators of hepcidin and F-box and leucine-rich repeat protein 5 (FBXL5) expression levels were significantly suppressed in CHC patients (p=0.0032 and p=0.016, respectively) despite their significantly higher levels of serum iron and ferritin compared with controls.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	46-54
26290259-6	2016	Systemic and intracellular iron regulators of hepcidin and F-box and leucine-rich repeat protein 5 (FBXL5) expression levels were significantly suppressed in CHC patients (p=0.0032 and p=0.016, respectively) despite their significantly higher levels of serum iron and ferritin compared with controls.	Iron	259-263	hepcidin antimicrobial peptide	Homo sapiens	46-54
26290259-8	2016	Significant correlations were observed among IL-6, bone morphogenetic protein 6, hepcidin and ferroportin, as regards systemic iron regulation.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	81-89
26290259-10	2016	Low baseline levels of the intracellular iron regulators of FBXL5 in addition to a suppressed hepcidin level might be associated with severe hepatic iron deposition in CHC patients.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	94-102
26858413-5	2016	The recombinant HBx protein contains metal ions, in particular iron and zinc.	Iron	63-67	X protein	Hepatitis B virus	16-19
26866603-1	2016	OBJECTIVE: Hepcidin reduces iron absorption by binding to the intestinal iron transporter ferroportin, thereby causing its degradation.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	11-19
26861293-5	2016	We showed that the expression pattern of Fer2LCH-Gal4 lines recapitulated iron-dependent endogenous expression of the ferritin subunits and used these lines to drive expression from UAS-mCherry-Fer2LCH transgenes.	Iron	74-78	Ferritin 2 light chain homologue	Drosophila melanogaster	41-48
26861293-7	2016	Endogenous Fer2LCH and Fer1HCH assembled and stored excess dietary iron, instead.	Iron	67-71	Ferritin 2 light chain homologue	Drosophila melanogaster	11-18
26861293-8	2016	In contrast, when flies were genetically manipulated to co-express Fer2LCH and mCherry-Fer2LCH simultaneously, both subunits were incorporated with Fer1HCH in iron-loaded ferritin complexes.	Iron	159-163	Ferritin 2 light chain homologue	Drosophila melanogaster	67-74
26861293-8	2016	In contrast, when flies were genetically manipulated to co-express Fer2LCH and mCherry-Fer2LCH simultaneously, both subunits were incorporated with Fer1HCH in iron-loaded ferritin complexes.	Iron	159-163	Ferritin 2 light chain homologue	Drosophila melanogaster	87-94
26845567-5	2016	Feeding of iron-deficient diet as well as erythropoietin treatment increased TMPRSS6 protein content in rats and mice by a posttranscriptional mechanism; the increase in TMPRSS6 protein by erythropoietin was also observed in Bmp6-mutant mice.	Iron	11-15	erythropoietin	Mus musculus	189-203
26845567-5	2016	Feeding of iron-deficient diet as well as erythropoietin treatment increased TMPRSS6 protein content in rats and mice by a posttranscriptional mechanism; the increase in TMPRSS6 protein by erythropoietin was also observed in Bmp6-mutant mice.	Iron	11-15	bone morphogenetic protein 6	Mus musculus	225-229
26491866-1	2016	The definition "iron loading anaemias" encompasses a group of inherited and acquired anaemias characterized by ineffective erythropoiesis, low hepcidin levels, excessive iron absorption and secondary iron overload.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	143-151
26561367-2	2016	Hepcidin is the central negative regulator of iron metabolism that is produced primarily by the liver.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
26561367-4	2016	RESULTS: Hepcidin values correlated weakly with serum ferritin levels (r = 0.33) and hepatic iron scores (r = 0.3).	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	9-17
26561367-6	2016	According to Cox multivariate analyses, lower hepcidin levels were independently associated with death [HR = 2.84 (1.29-6.25), P = 0.009] along with higher Child-Pugh score while HCC occurrence was mainly associated with clinical confounders interfering with iron metabolism (older age and higher BMI, adjusted P-value for hepcidin = 0.119).	Iron	259-263	hepcidin antimicrobial peptide	Homo sapiens	46-54
26675814-0	2016	Identification of mutation in GTPBP2 in patients of a family with neurodegeneration accompanied by iron deposition in the brain.	Iron	99-103	GTP binding protein 2	Homo sapiens	30-36
26602290-1	2016	OBJECTIVE: The aim of this study was to evaluate the effect of supplementation with bovine lactoferrin (bLf) from iron-fortified formulas on diarrhea and respiratory tract infections (RTIs) in weaned infants.	Iron	114-118	lactotransferrin	Bos taurus	91-102
26381228-0	2016	A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.	Iron	56-60	thioredoxin domain containing 5	Homo sapiens	15-42
26381228-10	2016	INNOVATION: IsTRP is the first member from the Trx family to be reported to bind Fe/S.	Iron	81-83	thioredoxin	Homo sapiens	47-50
26381228-11	2016	We disclose a novel mechanism of Fe/S coordination within the Trx folding unit, which renders the cluster highly resistant to oxidation-mediated disassembly.	Iron	33-35	thioredoxin	Homo sapiens	62-65
26381228-12	2016	CONCLUSION: We demonstrate that IsTRP defines a new protein family within the Trx superfamily, confirm the conservation of function for class II Grx from nonphylogenetically related species, and highlight the versatility of the Trx folding unit to acquire Fe/S binding as a recurrent emergent function.	Iron	256-258	thioredoxin	Homo sapiens	228-231
26707217-5	2016	Active immunization of mice with recombinant antigens EcpA, EcpD, IutA, or IroN elicited high levels of total IgG antibody of IgG1/IgG2a isotypes, and were determined to be highly protective against E. coli infection in lethal and non-lethal sepsis challenges.	Iron	75-79	immunoglobulin heavy variable V1-9	Mus musculus	131-136
26776506-4	2016	Under an iron-deprived diet (2-3 mg/kg), mice failed to release iron from ferritin storage and developed severe microcytic hypochromic anemia and ineffective erythropoiesis associated with increased erythropoietin levels.	Iron	9-13	erythropoietin	Mus musculus	199-213
26807955-2	2016	The expression of hepcidin, an iron-regulatory and acute phase protein synthesized by the liver, is also modulated.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	18-26
26775621-4	2016	The responses of the domain structure of the Bi1-deltaFe0.95Mn0.05O3 film under positive and negative applied voltages directly suggested the coexistence of FE and AFE phases.	Iron	157-159	transmembrane BAX inhibitor motif containing 6	Homo sapiens	45-48
26788262-7	2016	Hepcidin is crucial in terms of maintaining appropriate amounts of iron in the body and is in turn affected by haemoglobinopathies.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
26551072-2	2016	The divalent metal transporter 1 (DMT1) is a major metal transporter involved in the absorption and metabolism of several essential metals like iron and manganese.	Iron	144-148	solute carrier family 11 member 2	Homo sapiens	4-32
26551072-2	2016	The divalent metal transporter 1 (DMT1) is a major metal transporter involved in the absorption and metabolism of several essential metals like iron and manganese.	Iron	144-148	solute carrier family 11 member 2	Homo sapiens	34-38
27669335-7	2016	Levels of mRNA for Tfr1 and Slc11a2, iron-responsive genes involved in iron uptake, were significantly elevated in DFO-treated cultures at 11DIV and 18DIV, indicating a degree of neuronal ID similar to that seen in rodent ID models.	Iron	37-41	solute carrier family 11 member 2	Homo sapiens	28-35
27669335-7	2016	Levels of mRNA for Tfr1 and Slc11a2, iron-responsive genes involved in iron uptake, were significantly elevated in DFO-treated cultures at 11DIV and 18DIV, indicating a degree of neuronal ID similar to that seen in rodent ID models.	Iron	71-75	solute carrier family 11 member 2	Homo sapiens	28-35
29431326-7	2016	The comparison of kinetics of DEPPD oxidation in model (HO/Fe) and biologic (rat serum/Fe) systems, before and after Fe addition, seems to be an evidence that ceruloplasmin (CP) was involved in the resulting process, but failed to determine its polynomial kinetics, at least for the rat serum and DEPPD excess.	Iron	59-61	ceruloplasmin	Homo sapiens	159-172
29431326-7	2016	The comparison of kinetics of DEPPD oxidation in model (HO/Fe) and biologic (rat serum/Fe) systems, before and after Fe addition, seems to be an evidence that ceruloplasmin (CP) was involved in the resulting process, but failed to determine its polynomial kinetics, at least for the rat serum and DEPPD excess.	Iron	87-89	ceruloplasmin	Homo sapiens	159-172
27321101-1	2016	OBJECTIVES: The amount of iron is regulated by hepcidin.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	47-55
27321101-2	2016	The aim of the study was to assess hepcidin concentrations in healthy pregnant women before delivery, in cord blood, and in 3-day-old newborns in relation to maternal and neonatal iron status.	Iron	180-184	hepcidin antimicrobial peptide	Homo sapiens	35-43
27321101-13	2016	CONCLUSIONS: It may be assumed that a relatively low concentration of hepcidin in women in late pregnancy facilitates their iron accumulation.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	70-78
27321101-14	2016	Higher levels of hepcidin in full-term newborns than in their mothers may be the result of a relatively high level of iron from the stored supplies.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	17-25
27321101-15	2016	Neonatal iron status was independently associated with either maternal or cord blood hepcidin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	85-93
26406355-2	2016	However, it is still not clear whether these molecules intersect in vivo with bone morphogenetic protein 6 (BMP6)/mothers against decapentaplegic (SMAD) homolog signaling, the main pathway up-regulating hepcidin expression in response to elevated hepatic iron.	Iron	255-259	bone morphogenetic protein 6	Mus musculus	108-112
26763035-0	2016	Ischemic stroke, inflammation, iron overload - Connection to a hepcidin.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	63-71
26100117-1	2016	Glutaredoxin 5 (GLRX5) is a 156 amino acid mitochondrial protein that plays an essential role in mitochondrial iron-sulfur cluster transfer.	Iron	111-115	glutaredoxin 5	Homo sapiens	0-14
26100117-1	2016	Glutaredoxin 5 (GLRX5) is a 156 amino acid mitochondrial protein that plays an essential role in mitochondrial iron-sulfur cluster transfer.	Iron	111-115	glutaredoxin 5	Homo sapiens	16-21
26100117-5	2016	We observed that the K101Q mutation (due to c. 301 A&gt;C mutation) may prevent the binding of [Fe-S] to GLRX5 protein, while L148S (due to c. 443 T&gt;C mutation) may interfere with [Fe-S] transfer from GLRX5 to iron regulatory protein 1 (IRP1), mitochondrial aconitase (m-aconitase) and ferrochelatase.	Iron	96-100	glutaredoxin 5	Homo sapiens	105-110
26100117-5	2016	We observed that the K101Q mutation (due to c. 301 A&gt;C mutation) may prevent the binding of [Fe-S] to GLRX5 protein, while L148S (due to c. 443 T&gt;C mutation) may interfere with [Fe-S] transfer from GLRX5 to iron regulatory protein 1 (IRP1), mitochondrial aconitase (m-aconitase) and ferrochelatase.	Iron	96-100	glutaredoxin 5	Homo sapiens	204-209
26100117-5	2016	We observed that the K101Q mutation (due to c. 301 A&gt;C mutation) may prevent the binding of [Fe-S] to GLRX5 protein, while L148S (due to c. 443 T&gt;C mutation) may interfere with [Fe-S] transfer from GLRX5 to iron regulatory protein 1 (IRP1), mitochondrial aconitase (m-aconitase) and ferrochelatase.	Iron	184-188	glutaredoxin 5	Homo sapiens	105-110
26100117-8	2016	Collectively, our current work demonstrates that GLRX5 protein is multifunctional in [Fe-S] protein synthesis and maturation and defects of the different amino acids of the protein will lead to distinct effects on downstream Fe/S biosynthesis.	Iron	86-88	glutaredoxin 5	Homo sapiens	49-54
26100117-8	2016	Collectively, our current work demonstrates that GLRX5 protein is multifunctional in [Fe-S] protein synthesis and maturation and defects of the different amino acids of the protein will lead to distinct effects on downstream Fe/S biosynthesis.	Iron	225-227	glutaredoxin 5	Homo sapiens	49-54
27172725-11	2016	Direct involvement of hepcidin in iron metabolism creates a prerequisite for the treatment of anemia.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	22-30
26688339-3	2016	NFU1 is an iron-sulfur cluster protein necessary for the activity of the mitochondrial respiratory chain complexes I-II and the synthesis of lipoic acid.	Iron	11-15	NFU1 iron-sulfur cluster scaffold	Homo sapiens	0-4
26764474-2	2016	The hierarchical master determinant of dietary iron absorption and iron distribution within the body is the peptide hormone hepcidin.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	124-132
26764474-2	2016	The hierarchical master determinant of dietary iron absorption and iron distribution within the body is the peptide hormone hepcidin.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	124-132
26764474-3	2016	Hepcidin itself is regulated by a combination of signals derived from iron stores, inflammation, and erythropoietic expansion.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
26764474-8	2016	Low levels of hepcidin allow iron absorption and effective iron incorporation into red blood cells.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	14-22
26764474-8	2016	Low levels of hepcidin allow iron absorption and effective iron incorporation into red blood cells.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	14-22
26764474-10	2016	Iron is also important in transplantation medicine and influences clinical outcome of arterial pulmonary hypertension; here too, biomarkers including hepcidin may be useful to actively and beneficially manage iron status.	Iron	209-213	hepcidin antimicrobial peptide	Homo sapiens	150-158
27298749-0	2016	Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson"s Disease.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
27298749-4	2016	Hepcidin, a hormone primarily produced by hepatocytes, acts as a key regulator in both systemic and cellular iron homeostasis.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	0-8
27298749-10	2016	Hepcidin knockdown (32.3%, P &lt; 0.0001) upregulated ferroportin 1 expression and significantly (P &lt; 0.05) decreased intracellular iron by 25%.	Iron	135-139	hepcidin antimicrobial peptide	Homo sapiens	0-8
27298749-12	2016	In addition, hepcidin knockdown significantly attenuated 6-OHDA induced protein carbonyls by 52% (P &lt; 0.05) and intracellular iron by 28% (P &lt; 0.01), indicating the role of hepcidin in oxidative stress.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	13-21
27298749-14	2016	Our results demonstrate that hepcidin knockdown protected N27 cells from 6-OHDA induced apoptosis and that hepcidin plays a major role in reducing cellular iron burden and oxidative damage by possibly regulating cellular iron export mediated by ferroportin 1.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	107-115
27298749-14	2016	Our results demonstrate that hepcidin knockdown protected N27 cells from 6-OHDA induced apoptosis and that hepcidin plays a major role in reducing cellular iron burden and oxidative damage by possibly regulating cellular iron export mediated by ferroportin 1.	Iron	221-225	hepcidin antimicrobial peptide	Homo sapiens	107-115
27298749-14	2016	Our results demonstrate that hepcidin knockdown protected N27 cells from 6-OHDA induced apoptosis and that hepcidin plays a major role in reducing cellular iron burden and oxidative damage by possibly regulating cellular iron export mediated by ferroportin 1.	Iron	221-225	solute carrier family 40 member 1	Homo sapiens	245-258
27725588-1	2016	Hepcidin is an iron-regulating peptide hormone made in the liver.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
27725588-3	2016	Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from all iron-transporting cells.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
27725588-3	2016	Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from all iron-transporting cells.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
27725588-3	2016	Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from all iron-transporting cells.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
27725588-4	2016	In a classical endocrine feedback system, hepcidin production is stimulated by plasma iron and iron stores.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	42-50
27725588-4	2016	In a classical endocrine feedback system, hepcidin production is stimulated by plasma iron and iron stores.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	42-50
27725588-6	2016	Increased erythropoietic activity suppresses hepcidin, which leads to increased iron absorption and release of iron from stores, matching iron supply to increased demand.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	45-53
27725588-6	2016	Increased erythropoietic activity suppresses hepcidin, which leads to increased iron absorption and release of iron from stores, matching iron supply to increased demand.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	45-53
27725588-6	2016	Increased erythropoietic activity suppresses hepcidin, which leads to increased iron absorption and release of iron from stores, matching iron supply to increased demand.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	45-53
27725588-9	2016	Pathologically increased concentrations of hepcidin are seen in iron-refractory iron deficiency anemia, in anemia of inflammation, and anemia of chronic kidney disease where increased hepcidin limits the availability of iron for erythropoiesis.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	43-51
27508376-7	2016	Phosphorus removal was significantly enhanced, exceeding 90% in E-BF by chemical precipitation, physical adsorption, and flocculation of phosphorus because of the in situ formation of ferric ions by the anodizing of sacrificial iron anodes.	Iron	228-232	EBF transcription factor 1	Homo sapiens	64-68
26671928-4	2015	TET proteins (TET1, TET2, TET3) are iron(II) and alpha-ketoglutarate dependent dioxygenases, and their enzymatic activity involves hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine and 5-carboxylcytosine.	Iron	36-40	tet methylcytosine dioxygenase 1	Homo sapiens	14-18
26183475-7	2015	To ensure that sufficient iron is provided, Epo-controlled erythroferrone that is expressed in erythroid precursor cells acts in the liver to reduce expression of the iron hormone hepcidin.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	180-188
26183475-7	2015	To ensure that sufficient iron is provided, Epo-controlled erythroferrone that is expressed in erythroid precursor cells acts in the liver to reduce expression of the iron hormone hepcidin.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	180-188
26183475-8	2015	Consequently, suppression of hepcidin allows for elevated iron release from storage organs and enhanced absorption of dietary iron by enterocytes.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	29-37
26183475-8	2015	Consequently, suppression of hepcidin allows for elevated iron release from storage organs and enhanced absorption of dietary iron by enterocytes.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	29-37
26561622-3	2015	Because hepcidin reduces iron efflux from the basolateral enterocyte, it is uncertain whether luminal enhancers of dietary iron absorption such as ascorbic acid can be effective in overweight and obese individuals.	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	8-16
26840464-19	2015	This is because of the inflammatory state and "blocking" of iron entry into enterocytes through hepcidin action on ferroportin, along with the elevated rates of gastrointestinal adverse events that compromise adherence to treatment and possibly aggravate the intestinal inflammatory state.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	96-104
26643575-1	2015	BACKGROUND: Serum levels of hepcidin-25, a peptide hormone that reduces blood iron content, are elevated when patients with cystic fibrosis (CF) develop pulmonary exacerbation (PEx).	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	28-36
25598480-1	2015	OBJECTIVES: As hepcidin-25 is considered as a key regulator of human iron homoeostasis, this study aimed to compare this parameter with conventional biomarkers and diagnostic tools of iron deficiency (ID).	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	15-23
26546695-0	2015	Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	24-32
26546695-1	2015	Hepcidin is a liver-derived antimicrobial peptide that regulates iron absorption and is also an integral part of the acute phase response.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	0-8
26546695-10	2015	The ability of phytoestrogens to modulate hepcidin expression in vivo suggests a novel mechanism by which diet may impact iron homeostasis.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	42-50
25761647-0	2015	Iron regulation of hepcidin through Hfe and Hjv: Common or distinct pathways?	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	19-27
25761647-0	2015	Iron regulation of hepcidin through Hfe and Hjv: Common or distinct pathways?	Iron	0-4	hemojuvelin BMP co-receptor	Homo sapiens	44-47
26542333-0	2015	Correction: DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration.	Iron	17-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	12-16
26679804-1	2015	Lactoferrin is an iron-binding protein found in cow"s milk that plays an important role in preventing mastitis caused by intramammary infection.	Iron	18-22	lactotransferrin	Bos taurus	0-11
26396185-2	2015	In Saccharomyces cerevisiae, Erv1 has also been implicated in cytosolic Fe-S protein maturation and iron regulation.	Iron	72-76	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	29-33
26396185-2	2015	In Saccharomyces cerevisiae, Erv1 has also been implicated in cytosolic Fe-S protein maturation and iron regulation.	Iron	100-104	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	29-33
26427876-0	2015	Caenorhabditis elegans ATAD-3 modulates mitochondrial iron and heme homeostasis.	Iron	54-58	ATPase family AAA domain-containing protein 3	Caenorhabditis elegans	23-29
26427876-5	2015	Here, we demonstrate that Caenorhabditis elegans ATAD-3 is involved in mitochondrial iron and heme homeostasis.	Iron	85-89	ATPase family AAA domain-containing protein 3	Caenorhabditis elegans	49-55
26427876-6	2015	Knockdown of atad-3 caused mitochondrial iron- and heme accumulation.	Iron	41-45	ATPase family AAA domain-containing protein 3	Caenorhabditis elegans	13-19
26427876-8	2015	In conclusion, our data indicate a regulatory role of C. elegans ATAD-3 in mitochondrial iron and heme metabolism.	Iron	89-93	ATPase family AAA domain-containing protein 3	Caenorhabditis elegans	65-71
25728673-5	2015	Protein kinase C-mediated HSPB1 phosphorylation confers protection against ferroptosis by reducing iron-mediated production of lipid reactive oxygen species.	Iron	99-103	heat shock protein family B (small) member 1	Homo sapiens	26-31
25728673-7	2015	Our findings reveal an essential role for HSPB1 in iron metabolism with important effects on ferroptosis-mediated cancer therapy.	Iron	51-55	heat shock protein family B (small) member 1	Homo sapiens	42-47
26109250-3	2015	Hepcidin is a newly identified iron metabolism regulating hormone, which could be a promising biomarker for many disorders.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
24569625-8	2015	CONCLUSION: Hepcidin levels are decreased independently from hs-CRP levels as a compensatory mechanism to increase the iron absorption in response to decreased serum iron levels in patients with RVD.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	12-20
24569625-8	2015	CONCLUSION: Hepcidin levels are decreased independently from hs-CRP levels as a compensatory mechanism to increase the iron absorption in response to decreased serum iron levels in patients with RVD.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	12-20
26135314-9	2015	Median hepcidin was lower in patients with ACD and iron restriction as indicated by LHD &gt;4% (17.5 ng/mL) than on those with no iron restriction (25.9 ng/mL; p=0.045).	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	7-15
26135314-9	2015	Median hepcidin was lower in patients with ACD and iron restriction as indicated by LHD &gt;4% (17.5 ng/mL) than on those with no iron restriction (25.9 ng/mL; p=0.045).	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	7-15
26733771-0	2015	Hepcidin/Ferritin Quotient Helps to Predict Spontaneous Recovery from Iron Loss following Blood Donation.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
26733771-6	2015	Along with ferritin, there was a high variation in hepcidin levels indicating inter-individual differences in hepcidin response to iron loss.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	51-59
26733771-6	2015	Along with ferritin, there was a high variation in hepcidin levels indicating inter-individual differences in hepcidin response to iron loss.	Iron	131-135	hepcidin antimicrobial peptide	Homo sapiens	110-118
26733771-8	2015	CONCLUSION: As hepcidin appears to integrate erythropoietic and iron-loading signals, clinical measurement of hepcidin (together with the hepcidin-ferritin ratio) may become a useful indicator of erythropoiesis and iron kinetics.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	15-23
26343458-1	2015	Systemic iron balance is governed by the liver-derived peptide hormone hepcidin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	71-79
26457677-1	2015	The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated forms of the hormone.	Iron	74-78	gastrin	Homo sapiens	20-27
26500891-0	2015	Decreased RXRalpha is Associated with Increased beta-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors.	Iron	73-75	transcription factor 4	Mus musculus	61-65
26500891-6	2015	We observed increased accumulation of the transcription factor TCF4 and its co-activator beta-catenin as well as their downstream oncogenic target protein cyclin-D1 in (56)Fe ion-induced intestinal tumors.	Iron	172-174	transcription factor 4	Mus musculus	63-67
26304124-2	2015	The human hepcidin gene, HAMP, is the master switch of iron metabolism.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	10-18
26304124-2	2015	The human hepcidin gene, HAMP, is the master switch of iron metabolism.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	25-29
26209012-0	2015	Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer"s disease patients.	Iron	62-66	ceruloplasmin	Homo sapiens	20-22
26211743-12	2015	In conclusion, TBXAS1 gene expression was downregulated in rats with iron-induced mesothelioma.	Iron	69-73	thromboxane A synthase 1	Rattus norvegicus	15-21
26211743-13	2015	The relationship between iron overload and TBXAS1 downregulation should be pursued further.	Iron	25-29	thromboxane A synthase 1	Rattus norvegicus	43-49
26199063-3	2015	Our aim was to determine whether hepcidin is increased in EPP/XLP patients, resulting in decreased enteral iron absorption and IDA.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	33-41
26199063-9	2015	Mean serum and urine hepcidin levels were significantly lower in the EPP-XLP group at 4 and 8 h post-iron (serum - 4 h, 3 79/26 6, 8 h, 5 79/34 6 nM; urine - 4 h, 0 85/2 50, 8 h, 1 44/6 63 nM/mM creatinine).	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	21-29
25749188-1	2015	Iron contributes to c-Jun N-terminal kinases (JNK) activation in young rats and white matter injury in piglets after intracerebral hemorrhage (ICH).	Iron	0-4	mitogen-activated protein kinase 8	Rattus norvegicus	20-44
25749188-1	2015	Iron contributes to c-Jun N-terminal kinases (JNK) activation in young rats and white matter injury in piglets after intracerebral hemorrhage (ICH).	Iron	0-4	mitogen-activated protein kinase 8	Rattus norvegicus	46-49
26230452-8	2015	The addition of a nano-Fe/Ca/CaO/PO4mixture with simple grinding technique is potentially applicable for the remediation and volume reduction of fly ash contaminated by heavy metals.	Iron	23-25	mummy	Drosophila melanogaster	29-32
26338889-7	2015	Absorption of non-heme iron from dal and from ferrous sulfate was inversely associated with serum ferritin (SF; r = -0.50, P = 0.05 and r = -0.81, P &lt; 0.001, respectively) and serum hepcidin (r = -0.45, P = 0.05 and r = -0.60, P = 0.007, respectively).	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	185-193
26338889-10	2015	Both SF and hepcidin were inversely associated with iron absorption from both a supplemental and a food-based non-heme iron source in nonanemic and anemic women.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	12-20
26338889-10	2015	Both SF and hepcidin were inversely associated with iron absorption from both a supplemental and a food-based non-heme iron source in nonanemic and anemic women.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	12-20
26412289-0	2015	Iron Deprivation May Enhance Insulin Receptor and Glut4 Transcription in Skeletal Muscle of Adult Rats.	Iron	0-4	solute carrier family 2 member 4	Rattus norvegicus	50-55
26412289-8	2015	In addition, dietary iron restriction resulted in a twofold increase in mRNA expression of Insr and fourfold increase in Glut4 expression in skeletal muscle.	Iron	21-25	solute carrier family 2 member 4	Rattus norvegicus	121-126
26360295-0	2015	DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration.	Iron	5-9	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
26360295-6	2015	To sum up, the present work unveils the role of DMT1 in mediating the neuroregenerative action of iron.	Iron	98-102	doublesex and mab-3 related transcription factor 1	Homo sapiens	48-52
25980471-9	2015	A significant decrease in microalbumin, LAP, FeNa, and urinary trace elements was observed post-iron therapy while hemoglobin and ferritin levels were increased (p &lt; 0.05).	Iron	96-100	LAP	Homo sapiens	40-43
26929573-7	2015	CONCLUSION: The present study demonstrated for the first time that the FE fraction from clove could confer UV-B protection probably through the Nrf2-ARE pathway, which included the down-regulation of Nrf2 and HO-1.	Iron	71-73	heme oxygenase 1	Homo sapiens	209-213
26964313-3	2015	Thus, in the present study, the human amino-terminal fragment (hATF), as a targeting element to uPAR, is used to conjugate to the surface of superparamagnetic iron nanoparticle (SPIO).	Iron	159-163	plasminogen activator, urokinase receptor	Homo sapiens	96-100
26195633-0	2015	The Yeast Nbp35-Cfd1 Cytosolic Iron-Sulfur Cluster Scaffold Is an ATPase.	Iron	31-35	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	10-15
26195633-0	2015	The Yeast Nbp35-Cfd1 Cytosolic Iron-Sulfur Cluster Scaffold Is an ATPase.	Iron	31-35	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	16-20
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	79-82	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	0-5
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	79-82	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	10-14
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	79-82	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	51-56
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	136-139	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	0-5
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	136-139	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	10-14
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	136-139	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	51-56
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	136-139	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	0-5
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	136-139	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	10-14
26195633-1	2015	Nbp35 and Cfd1 are prototypical members of the MRP/Nbp35 class of iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes.	Iron	136-139	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	51-56
26296885-3	2015	During anemia, the hypoxic response via the transcription factor hypoxia-inducible factor (HIF)-2alpha is highly activated in the intestine and is essential in iron absorption.	Iron	160-164	endothelial PAS domain protein 1	Mus musculus	65-102
26296885-4	2015	Intestinal disruption of HIF-2alpha protects against tissue iron accumulation in iron overload anemias.	Iron	60-64	endothelial PAS domain protein 1	Mus musculus	25-35
26296885-4	2015	Intestinal disruption of HIF-2alpha protects against tissue iron accumulation in iron overload anemias.	Iron	81-85	endothelial PAS domain protein 1	Mus musculus	25-35
26296885-6	2015	Here we show that in mouse models of SCD, disruption of intestinal HIF-2alpha significantly decreased tissue iron accumulation.	Iron	109-113	endothelial PAS domain protein 1	Mus musculus	67-77
26394303-2	2015	Hepcidin, the hormone responsible for governing systemic iron homeostasis, is widely hypothesized to represent a key component of nutritional immunity through regulating the accessibility of iron to invading microorganisms during infection.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	0-8
26394303-2	2015	Hepcidin, the hormone responsible for governing systemic iron homeostasis, is widely hypothesized to represent a key component of nutritional immunity through regulating the accessibility of iron to invading microorganisms during infection.	Iron	191-195	hepcidin antimicrobial peptide	Homo sapiens	0-8
26394303-12	2015	We hypothesize that hepcidin-mediated iron redistribution into macrophages may contribute to S. Typhi pathogenesis by increasing iron availability for macrophage-tropic bacteria, and that targeting macrophage iron retention may represent a strategy for limiting infections with macrophage-tropic pathogens such as S. Typhi.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	20-28
26394303-12	2015	We hypothesize that hepcidin-mediated iron redistribution into macrophages may contribute to S. Typhi pathogenesis by increasing iron availability for macrophage-tropic bacteria, and that targeting macrophage iron retention may represent a strategy for limiting infections with macrophage-tropic pathogens such as S. Typhi.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	20-28
26394303-12	2015	We hypothesize that hepcidin-mediated iron redistribution into macrophages may contribute to S. Typhi pathogenesis by increasing iron availability for macrophage-tropic bacteria, and that targeting macrophage iron retention may represent a strategy for limiting infections with macrophage-tropic pathogens such as S. Typhi.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	20-28
26208637-0	2015	Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux.	Iron	120-124	solute carrier family 11 member 2	Homo sapiens	82-86
26208637-4	2015	Nramp2 is located exclusively in the contractile vacuole membrane and controls, synergistically with Nramp1, iron homeostasis.	Iron	109-113	solute carrier family 11 member 2	Homo sapiens	0-6
26125411-3	2015	In this study, we examined the role of iron metabolism in modulating TLR4 signaling in these cells.	Iron	39-43	toll like receptor 4	Homo sapiens	69-73
26047847-1	2015	Divalent metal transporter-1 (SLC11A2/DMT1) uses the H(+) electrochemical gradient as the driving force to transport divalent metal ions such as Fe(2+), Mn(2+) and others metals into mammalian cells.	Iron	145-147	solute carrier family 11 member 2	Homo sapiens	30-37
26047847-1	2015	Divalent metal transporter-1 (SLC11A2/DMT1) uses the H(+) electrochemical gradient as the driving force to transport divalent metal ions such as Fe(2+), Mn(2+) and others metals into mammalian cells.	Iron	145-147	solute carrier family 11 member 2	Homo sapiens	38-42
26142324-7	2015	Results reveal that a decrease in the free alpha chain pool, and hence the repertoire of unbound iron, due to elevated HbF and/or the presence of nucleated RBCs in the peripheral blood results in the upregulation of the AHSP gene.	Iron	97-101	alpha hemoglobin stabilizing protein	Homo sapiens	220-224
26275132-0	2015	CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet.	Iron	34-38	CD1 antigen complex	Mus musculus	0-3
26275132-0	2015	CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet.	Iron	65-69	CD1 antigen complex	Mus musculus	0-3
26257368-3	2015	Hepcidin-ferroportin (FPN) signaling is one of the key mechanisms responsible for iron supply, utilization, recycling, and storage, and recent studies demonstrated that exposure to environmental pollutants including POPs and heavy metals could lead to disruption of the hepcidin-FPN axis along with disordered systemic iron homeostasis and diseases.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
26140935-2	2015	Adsorption of ceruloplasmin (Cp) at a gold electrode modified with ferromagnetic iron nanoparticles encapsulated in carbon (Fe@C Nps) leads to a successful immobilization of the enzyme in its electroactive form.	Iron	81-85	ceruloplasmin	Homo sapiens	14-27
26140935-2	2015	Adsorption of ceruloplasmin (Cp) at a gold electrode modified with ferromagnetic iron nanoparticles encapsulated in carbon (Fe@C Nps) leads to a successful immobilization of the enzyme in its electroactive form.	Iron	124-126	ceruloplasmin	Homo sapiens	14-27
26079848-23	2015	The redox-complemented complex [Fe2(adt(Bn))(CO)3(dppv)(FcP*)](n+) catalyzes both proton reduction and hydrogen oxidation (FcP* = (C5Me5)Fe(C5Me4CH2PEt2)).	Iron	32-34	HBFQTL2	Homo sapiens	56-60
26079848-23	2015	The redox-complemented complex [Fe2(adt(Bn))(CO)3(dppv)(FcP*)](n+) catalyzes both proton reduction and hydrogen oxidation (FcP* = (C5Me5)Fe(C5Me4CH2PEt2)).	Iron	32-34	HBFQTL2	Homo sapiens	123-127
26173596-9	2015	Associations between Cd and PEG3 and PLAGL1 DNA methylation were stronger in infants born to women with low concentrations of Fe (p &lt; 0.05).	Iron	126-128	paternally expressed 3	Homo sapiens	28-32
25896304-0	2015	Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation.	Iron	69-73	hemojuvelin BMP co-receptor	Rattus norvegicus	36-40
26070639-10	2015	KEY RESULTS: SlbHLH068 is highly upregulated in roots, leaves and stems in response to iron deficiency.	Iron	87-91	transcription factor bHLH100	Solanum lycopersicum	13-22
26070639-13	2015	The downregulation of SlbHLH068 expression by VIGS resulted in a reduction of LeFRO1 and LeIRT1 expression and iron accumulation in leaves and roots.	Iron	111-115	transcription factor bHLH100	Solanum lycopersicum	22-31
25843914-4	2015	These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	41-49
25843914-5	2015	Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	63-71
25737209-3	2015	The classical model of iron metabolism with iron response element/iron response protein (IRE/IRP) is now extended to include hepcidin model.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	125-133
25737209-6	2015	The majority of the hereditary hemochromatosis (HH) patients are now shown to have mutations in the genes coding either upstream or downstream proteins of hepcidin, resulting in iron overload.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	155-163
25737209-7	2015	The update on hepcidin centered mechanisms of iron metabolism and their clinical perspective in hemochromatosis will be discussed in this review.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	14-22
26170904-5	2015	The identification of hepcidin was a key development in the field of iron metabolism in the previous decade.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	22-30
26170904-6	2015	We hypothesize that hepcidin may aid in the prevention and treatment of PMOP due to its capacity to control body iron stores and its intrinsic effects on osteoblast function.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	20-28
26595496-2	2015	Heme oxygenase-1(HO-1) metabolizes heme into biliverdin, bilirubin, carbon monoxide, and iron, our recent study showed that serum level of HO-1 was increased in stroke patients, yet the association of HO-1 level with risk of intracerebral hemorrhage (ICH) is poorly known.	Iron	89-93	heme oxygenase 1	Homo sapiens	0-16
25990830-3	2015	Myosin isolated from pork muscle was solubilized in 0.5 M NaCl at pH 6.2 then oxidatively stressed with an iron-redox cycling system that produces hydroxyl radicals with or without 1 mM PP and 2 mM MgCl2 at 4  C for 12 or 24 h then heated to 50  C at 1.3  C/min.	Iron	107-111	myosin heavy chain 14	Homo sapiens	0-6
25800177-5	2015	For M1 HM activation, heightened proinflammatory iron redox signaling in endosomes or caveosomes results from altered iron metabolism and storage, promoting IKK/NF-kB activation via interactive activation of p21ras, TAK1, and PI3K.	Iron	49-53	HRas proto-oncogene, GTPase	Homo sapiens	208-214
25800177-5	2015	For M1 HM activation, heightened proinflammatory iron redox signaling in endosomes or caveosomes results from altered iron metabolism and storage, promoting IKK/NF-kB activation via interactive activation of p21ras, TAK1, and PI3K.	Iron	49-53	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	216-220
25907691-2	2015	BMP and IL-6 signaling act via Smad and Stat3 transcription factors, respectively, to increase expression of hepcidin, the master regulator of iron metabolism.	Iron	143-147	signal transducer and activator of transcription 3	Rattus norvegicus	40-45
26039655-1	2015	We report the photochemical generation and study of a family of water-soluble iron(IV)-oxo complexes supported by pentapyridine PY5Me2-X ligands (PY5Me2 = 2,6-bis(1,1-bis(2-pyridyl)ethyl)pyridine; X = CF3, H, Me, or NMe2), in which the oxidative reactivity of these ferryl species correlates with the electronic properties of the axial pyridine ligand.	Iron	78-82	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	216-220
26106291-0	2015	Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology.	Iron	77-81	solute carrier family 11 member 2	Homo sapiens	0-28
26106291-0	2015	Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology.	Iron	77-81	solute carrier family 11 member 2	Homo sapiens	30-34
26106291-2	2015	In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells.	Iron	122-126	solute carrier family 11 member 2	Homo sapiens	76-104
26106291-2	2015	In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells.	Iron	122-126	solute carrier family 11 member 2	Homo sapiens	106-110
26106291-3	2015	DMT1 locates to cellular membranes and endosomal membranes, where it is a key player in non-transferrin bound iron uptake and transferrin-bound iron uptake, respectively.	Iron	110-114	solute carrier family 11 member 2	Homo sapiens	0-4
26106291-3	2015	DMT1 locates to cellular membranes and endosomal membranes, where it is a key player in non-transferrin bound iron uptake and transferrin-bound iron uptake, respectively.	Iron	144-148	solute carrier family 11 member 2	Homo sapiens	0-4
26106291-4	2015	Four isoforms of DMT1 exist, and their respective characteristics involve a complex cell-specific regulatory machinery all controlling iron transport across these membranes.	Iron	135-139	solute carrier family 11 member 2	Homo sapiens	17-21
26106291-9	2015	This supports existing evidence that iron uptake at the BBB occurs by means of transferrin-receptor mediated endocytosis followed by detachment of iron from transferrin inside the acidic compartment of the endosome and DMT1-mediated pumping iron into the cytosol.	Iron	37-41	solute carrier family 11 member 2	Homo sapiens	219-223
26035688-1	2015	Lactoferrin (Lf) can bind to lactoferrin receptor (LfR), leading to iron transport through the plasma membrane.	Iron	68-72	lactotransferrin	Mus musculus	0-11
26035688-1	2015	Lactoferrin (Lf) can bind to lactoferrin receptor (LfR), leading to iron transport through the plasma membrane.	Iron	68-72	lactotransferrin	Mus musculus	13-15
26035688-6	2015	How iron influences microglia to release Lf?	Iron	4-8	lactotransferrin	Mus musculus	41-43
26035688-7	2015	Does Lf tend to transport iron to dopaminergic neurons leading to cell death or to protect dopaminergic neuron from neurotoxin?	Iron	26-30	lactotransferrin	Mus musculus	5-7
26035688-8	2015	In this study, we observed that iron increased Lf synthesis in activated microglia.	Iron	32-36	lactotransferrin	Mus musculus	47-49
26035688-9	2015	In ventral mesencephalon neurons, both iron-free Lf (apo-Lf) and iron-saturated Lf (holo-Lf) exerted neuroprotective effects against MPP(+) by mechanisms, believed to enhance the mitochondrial transmembrane potential, improve Cu/Zn-superoxide dismutase activity, increase Bcl-2 expression.	Iron	39-43	lactotransferrin	Mus musculus	49-51
26035688-9	2015	In ventral mesencephalon neurons, both iron-free Lf (apo-Lf) and iron-saturated Lf (holo-Lf) exerted neuroprotective effects against MPP(+) by mechanisms, believed to enhance the mitochondrial transmembrane potential, improve Cu/Zn-superoxide dismutase activity, increase Bcl-2 expression.	Iron	39-43	lactotransferrin	Mus musculus	57-59
26035688-9	2015	In ventral mesencephalon neurons, both iron-free Lf (apo-Lf) and iron-saturated Lf (holo-Lf) exerted neuroprotective effects against MPP(+) by mechanisms, believed to enhance the mitochondrial transmembrane potential, improve Cu/Zn-superoxide dismutase activity, increase Bcl-2 expression.	Iron	39-43	lactotransferrin	Mus musculus	57-59
26035688-9	2015	In ventral mesencephalon neurons, both iron-free Lf (apo-Lf) and iron-saturated Lf (holo-Lf) exerted neuroprotective effects against MPP(+) by mechanisms, believed to enhance the mitochondrial transmembrane potential, improve Cu/Zn-superoxide dismutase activity, increase Bcl-2 expression.	Iron	65-69	lactotransferrin	Mus musculus	84-91
26035688-11	2015	Our data indicate that iron overload increases the activated microglia releasing Lf.	Iron	23-27	lactotransferrin	Mus musculus	81-83
26035688-12	2015	Lf plays protective role on ventral mesencephalon neurons against MPP(+), which is iron-chelating independent.	Iron	83-87	lactotransferrin	Mus musculus	0-2
25855377-2	2015	Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma cells and correlates negatively with clinic outcome.	Iron	33-37	solute carrier family 40 member 1	Homo sapiens	132-136
25855377-2	2015	Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma cells and correlates negatively with clinic outcome.	Iron	105-109	solute carrier family 40 member 1	Homo sapiens	132-136
25855377-3	2015	Restoring expression of FPN1 reduces intracellular liable iron pool, inhibits STAT3-MCL-1 signaling, and suppresses myeloma cells growth.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	24-28
26059599-7	2015	Countering these factors, the iron-loaded livers demonstrated a significant decrease in CHOP, which has recently been implicated in the development of hepatocellular carcinoma, as well as a reciprocal increase in C/EBPalpha and decrease in Yes-associated protein.	Iron	30-34	DNA-damage inducible transcript 3	Rattus norvegicus	88-92
25011936-1	2015	OBJECTIVE: Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis.	Iron	91-95	bone morphogenetic protein 6	Mus musculus	11-39
25011936-1	2015	OBJECTIVE: Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis.	Iron	91-95	bone morphogenetic protein 6	Mus musculus	41-45
25715089-8	2015	RESULTS: Dietary iron restriction gradually induced anemia, Epo secretion, and cardiac hypertrophy in wild-type mice.	Iron	17-21	erythropoietin	Mus musculus	60-63
25715089-9	2015	In contrast, EpoR-restricted mice fed with an iron-restricted diet exhibited anemia, left ventricular dilatation, and cardiac dysfunction compared with wild-type mice.	Iron	46-50	erythropoietin receptor	Mus musculus	13-17
25734366-6	2015	Similarly, Rankl expression peaked in marrow cells within 3 days of iron exposure (9.2-fold).	Iron	68-72	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	11-16
25649872-4	2015	Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation.	Iron	163-167	STEAP2 metalloreductase	Rattus norvegicus	16-22
25715026-11	2015	HIF2alpha protein expression was increased in megakaryocytes from iron-deficient rats, and VEGF-A concentration was higher in iron-deficient culture supernatants.	Iron	126-130	vascular endothelial growth factor A	Rattus norvegicus	91-97
26484234-0	2015	Transcriptomic analyses of maize ys1 and ys3 mutants reveal maize iron homeostasis.	Iron	66-70	iron-phytosiderophore transporter yellow stripe 1	Zea mays	33-36
26484234-1	2015	To acquire iron (Fe), graminaceous plants secrete mugineic acid family phytosiderophores (MAs) (Takagi, 1976 [1]) through the MAs efflux transporter TOM1 (Nozoye et al., 2011 [2]) and take up Fe in the form of Fe(III)-MAs complexes through the Fe(III)-MAs transporter YS1 (Curie et al., 2001 [3]).	Iron	11-15	iron-phytosiderophore transporter yellow stripe 1	Zea mays	268-271
26484234-1	2015	To acquire iron (Fe), graminaceous plants secrete mugineic acid family phytosiderophores (MAs) (Takagi, 1976 [1]) through the MAs efflux transporter TOM1 (Nozoye et al., 2011 [2]) and take up Fe in the form of Fe(III)-MAs complexes through the Fe(III)-MAs transporter YS1 (Curie et al., 2001 [3]).	Iron	17-19	iron-phytosiderophore transporter yellow stripe 1	Zea mays	268-271
26484234-5	2015	The objective of the present work was to identify the genes responsible for the ys1 and ys3 phenotypes, so as to extend our understanding of Fe homeostasis in maize by qRT-PCR.	Iron	141-143	iron-phytosiderophore transporter yellow stripe 1	Zea mays	80-83
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	19-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	44-47
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	19-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	108-111
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	19-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	108-111
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	19-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	251-256
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	80-84	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	44-47
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	140-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	44-47
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	140-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	108-111
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	140-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	108-111
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	140-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	44-47
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	140-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	108-111
25897079-7	2015	Second, disrupting Fe-S cluster assembly on XPD by either 1) depleting cellular iron levels or 2) utilizing XPD mutants defective in either Fe-S cluster or CIA targeting complex binding blocks Fe-S cluster assembly and prevents XPD incorporation into TFIIH.	Iron	140-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	108-111
25897079-9	2015	Together, these data establish a sequential assembly process for Fe-S assembly on XPD and highlight the existence of quality control mechanisms that prevent the incorporation of immature apoproteins into their cellular complexes.	Iron	65-69	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	82-85
25998617-0	2015	Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer.	Iron	0-4	lactotransferrin	Bos taurus	36-47
25998617-0	2015	Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer.	Iron	14-18	lactotransferrin	Bos taurus	36-47
25998617-1	2015	BACKGROUND: Iron binding, naturally occurring protein bovine lactoferrin (bLf) has attracted attention as a safe anti-cancer agent capable of inducing apoptosis.	Iron	12-16	lactotransferrin	Bos taurus	61-72
26042083-6	2015	c-rel(-/-) mice show increased level of aberrantly acetylated RelA in the basal ganglia, neuroinflammation, accumulation of alpha-synuclein, and iron.	Iron	145-149	reticuloendotheliosis oncogene	Mus musculus	0-5
25802332-10	2015	Mice with a mosaic pattern of RPE-specific iron overload demonstrated co-localization of iron-induced ferritin and C3d deposits.	Iron	43-47	endogenous retrovirus group K member 13	Homo sapiens	115-118
25802332-10	2015	Mice with a mosaic pattern of RPE-specific iron overload demonstrated co-localization of iron-induced ferritin and C3d deposits.	Iron	89-93	endogenous retrovirus group K member 13	Homo sapiens	115-118
25802332-11	2015	Humans with aceruloplasminemia causing RPE iron overload had increased RPE C3d deposition.	Iron	43-47	endogenous retrovirus group K member 13	Homo sapiens	75-78
25955433-1	2015	This study investigates the regulation of hepcidin, the key iron-regulatory molecule, by alcohol and hydrogen peroxide (H2O2) in glutathione peroxidase-1 (gpx-1(-/-)) and catalase (catalase(-/-)) knockout mice.	Iron	60-64	glutathione peroxidase 1	Mus musculus	129-153
25817364-5	2015	Divalent metal transporter 1 (DMT1) is one protein responsible for iron transport.	Iron	67-71	solute carrier family 11 member 2	Homo sapiens	0-28
25817364-5	2015	Divalent metal transporter 1 (DMT1) is one protein responsible for iron transport.	Iron	67-71	solute carrier family 11 member 2	Homo sapiens	30-34
25178559-8	2015	In the haemodialysis group, hepcidin was increased and correlated with serum ferritin, Tf, total iron binding capacity and sTfR1.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	28-36
25633564-1	2015	Hepcidin is the central regulator of systemic iron homeostasis; dysregulation of hepcidin expression causes various iron metabolic disorders, including hereditary hemochromatosis and anemia of inflammation.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
25633564-1	2015	Hepcidin is the central regulator of systemic iron homeostasis; dysregulation of hepcidin expression causes various iron metabolic disorders, including hereditary hemochromatosis and anemia of inflammation.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	81-89
25911308-5	2015	Iron scoring was performed according to Sindram &amp; Marx and MTK1-3 scoring systems.	Iron	0-4	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	63-67
25911308-8	2015	The relationship between the variables HIC, HII (hepatic iron index) and all histological gradings of iron (S&amp;M and MTK1-3) was very strong.	Iron	57-61	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	120-126
25911308-8	2015	The relationship between the variables HIC, HII (hepatic iron index) and all histological gradings of iron (S&amp;M and MTK1-3) was very strong.	Iron	102-106	MyoD family inhibitor domain containing	Homo sapiens	39-42
25911308-8	2015	The relationship between the variables HIC, HII (hepatic iron index) and all histological gradings of iron (S&amp;M and MTK1-3) was very strong.	Iron	102-106	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	120-126
25547425-6	2015	Serum hepcidin level was very low, indicating increased absorption of iron secondary to ineffective erythropoiesis.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	6-14
26349236-2	2015	As has been shown, iron-ore waste causes an increase in the acid phosphatase, nuclease, and beta-galactosidase activities of the host and a decrease in its beta-glucosidase and cathepsin D activities.	Iron	19-23	cathepsin D	Esox lucius	177-188
25727353-2	2015	Ferritin is being explored as a novel and natural strategy for iron supplementation.	Iron	63-67	ferritin-1, chloroplastic	Glycine max	0-8
25727353-3	2015	The objective of this study was to evaluate iron bioavailability from ferritin isolated from plant and animal sources.	Iron	44-48	ferritin-1, chloroplastic	Glycine max	70-78
25727353-6	2015	Furthermore, ferritin was labeled with (59)Fe, and bioavailability of iron from ferritin was assessed by uptake into Caco-2 cells.	Iron	43-45	ferritin-1, chloroplastic	Glycine max	13-21
25727353-6	2015	Furthermore, ferritin was labeled with (59)Fe, and bioavailability of iron from ferritin was assessed by uptake into Caco-2 cells.	Iron	70-74	ferritin-1, chloroplastic	Glycine max	80-88
25727353-7	2015	Our results indicate that iron is taken up from the ferritins and that iron bioavailability from soybean ferritin (rH-1:rH-2=1:1) is the highest.	Iron	26-30	ferritin-1, chloroplastic	Glycine max	52-60
25727353-9	2015	In conclusion, ferritin from plant and animal sources may be developed as an iron source.	Iron	77-81	ferritin-1, chloroplastic	Glycine max	15-23
25652229-9	2015	In LLC-PK1 cells, 10 mug ml(-1) iron (24 h) increased both aconitase activity (30%) and secreted glutamate levels (65%).	Iron	32-36	pyruvate kinase L/R	Rattus norvegicus	7-10
25107374-6	2015	Increase in CIMT was found to be correlated with levels of cobalt, copper, iron, magnesium, manganese, and zinc.	Iron	75-79	CIMT	Homo sapiens	12-16
25972885-0	2015	Integration of P, S, Fe, and Zn nutrition signals in Arabidopsis thaliana: potential involvement of PHOSPHATE STARVATION RESPONSE 1 (PHR1).	Iron	21-23	phosphate starvation response 1	Arabidopsis thaliana	133-137
25972885-10	2015	However, a MYB-like transcription factor, PHOSPHATE STARVATION RESPONSE 1, emerges as a common regulator of phosphate, sulfate, zinc, and iron homeostasis, and its role as a potential general integrator for the control of mineral nutrition is discussed.	Iron	138-142	phosphate starvation response 1	Arabidopsis thaliana	42-73
25899529-8	2015	CONCLUSION: These findings demonstrate that the activity of beta2-M is mediated by the beta2-M/HFE complex, which regulates intracellular iron homeostasis and HIF-1alpha and ultimately induces EMT in HK2 cells.	Iron	138-142	beta-2-microglobulin	Homo sapiens	87-94
25894587-3	2015	In this cohort study, we evaluated the impact of hepcidin-25--the key hormone of iron-metabolism--on clinical outcomes in diabetic patients with CKD along with endogenous EPO levels.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	49-57
24909164-8	2015	Moreover, SIRT3 null mice exhibit higher levels of iron and TfR1 expression in the pancreas.	Iron	51-55	sirtuin 3	Mus musculus	10-15
25860887-9	2015	However, in the same cells ferritin L was only slightly increased, but the iron content was not, suggesting that Bmp6 in these cells reflects the high intracellular iron import and export.	Iron	165-169	bone morphogenetic protein 6	Mus musculus	113-117
25860887-10	2015	We propose that NPCs, sensing the iron flux, not only increase hepcidin through Bmp6 with a paracrine mechanism to control systemic iron homeostasis but, controlling hepcidin, they regulate their own ferroportin, inducing iron retention or release and further modulating Bmp6 production in an autocrine manner.	Iron	34-38	bone morphogenetic protein 6	Mus musculus	80-84
25860887-10	2015	We propose that NPCs, sensing the iron flux, not only increase hepcidin through Bmp6 with a paracrine mechanism to control systemic iron homeostasis but, controlling hepcidin, they regulate their own ferroportin, inducing iron retention or release and further modulating Bmp6 production in an autocrine manner.	Iron	34-38	bone morphogenetic protein 6	Mus musculus	271-275
25557470-1	2015	Iron refractory iron deficiency anemia (IRIDA) is a rare hereditary disease caused by mutations in TMPRSS6 gene encoding Matriptase-2, a negative regulator of hepcidin transcription.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	159-167
25315005-8	2015	Dietary iron modulates levels of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), a transcriptional activator of ALAS1, to affect hepatic heme.	Iron	8-12	aminolevulinic acid synthase 1	Mus musculus	146-151
25089372-1	2015	Ceruloplasmin is a member of the multicopper oxidase family that plays a major role in the transport of iron in the body.	Iron	104-108	ceruloplasmin	Homo sapiens	0-13
26309436-0	2015	Study of Serum Hepcidin as a Potential Mediator of the Disrupted Iron Metabolism in Obese Adolescents.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	15-23
26309436-3	2015	We aimed to study the relation between serum hepcidin level and both iron as well as high sensitive CRP status in obese adolescents.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	45-53
26309436-8	2015	Serum hepcidin level correlated positively with BMI and hs- CRP, but negatively with iron level in obese group.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	6-14
25156780-3	2015	Previously, we reported that oxidative stress in male transgenic mice that expressed hepatitis C virus polyprotein (HCVTgM) caused hepatic iron accumulation by reducing hepcidin transcription, thereby leading to HCC development.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	169-177
25156780-8	2015	CONCLUSIONS: BCAA supplementation reduced oxidative stress by restoring mitochondrial function and improved iron metabolism by increasing hepcidin-25 in both iron-overloaded HCVTgM and patients with HCV-related advanced fibrosis.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	138-146
25634434-8	2015	Analysis of the non-synonymous SNVs that were not shared between the two family members revealed non-synonymous SNVs related to parkinsonism including a novel heterozygous mutation (p.T44N) in FBX07 (PARK15) only in the proband, and non-synonymous SNVs related to neurodegeneration with brain iron accumulation in the affected brother.	Iron	293-297	F-box protein 7	Homo sapiens	193-198
25634434-8	2015	Analysis of the non-synonymous SNVs that were not shared between the two family members revealed non-synonymous SNVs related to parkinsonism including a novel heterozygous mutation (p.T44N) in FBX07 (PARK15) only in the proband, and non-synonymous SNVs related to neurodegeneration with brain iron accumulation in the affected brother.	Iron	293-297	F-box protein 7	Homo sapiens	200-206
25471486-0	2015	Activity of cytochrome P450 1A2 in relation to hepatic iron accumulation in transfusion-dependent beta-thalassaemia major patients.	Iron	55-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-31
25471486-3	2015	The aim of this study was to assess the activity of CYP1A2 in relation to hepatic iron load in patients with transfusion-dependent beta-thalassaemia major.	Iron	82-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-58
25471486-6	2015	CYP1A2 activity was correlated with clinical and laboratory parameters and hepatic iron accumulation by T2* magnetic resonance imaging (T2*MRI).	Iron	83-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
25471486-9	2015	Low CYP1A2 activity was negatively associated with hepatic iron accumulation (T2*MRI &lt;= 6.3 ms); adjusted odds ratio (OR; 95% CI) for hepatic iron accumulation in patients with low CYP1A2 activity was 0.047 (0.003-0.72; P = 0.021).	Iron	59-63	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
25471486-9	2015	Low CYP1A2 activity was negatively associated with hepatic iron accumulation (T2*MRI &lt;= 6.3 ms); adjusted odds ratio (OR; 95% CI) for hepatic iron accumulation in patients with low CYP1A2 activity was 0.047 (0.003-0.72; P = 0.021).	Iron	145-149	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10
25471486-10	2015	Of the six patients with decreased activity of CYP1A2, five had no hepatic iron accumulation and one had mild hepatic iron accumulation by T2*MRI.	Iron	75-79	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53
25471486-10	2015	Of the six patients with decreased activity of CYP1A2, five had no hepatic iron accumulation and one had mild hepatic iron accumulation by T2*MRI.	Iron	118-122	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53
25471486-11	2015	CONCLUSION: Activity of CYP1A2 is associated with hepatic iron accumulation in patients with transfusion-depended beta-thalassaemia major.	Iron	58-62	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	24-30
25471486-12	2015	Further studies are needed to assess the exact role of CYP1A2 in iron metabolism in human.	Iron	65-69	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	55-61
25916292-0	2015	[The role of serum hepcidin and ferroportin1 in placenta on iron transfer from mother to fetus].	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	19-27
25916292-0	2015	[The role of serum hepcidin and ferroportin1 in placenta on iron transfer from mother to fetus].	Iron	60-64	solute carrier family 40 member 1	Homo sapiens	32-44
25916292-1	2015	OBJECTIVE: To detect the concentration of serum hepcidin and the mRNA expression level of ferroportin1 (FPN1) in the placenta membrane from full term pregnant women with different degree of iron deficiency, and explore their roles for iron transport in placental.	Iron	190-194	solute carrier family 40 member 1	Homo sapiens	90-102
25916292-1	2015	OBJECTIVE: To detect the concentration of serum hepcidin and the mRNA expression level of ferroportin1 (FPN1) in the placenta membrane from full term pregnant women with different degree of iron deficiency, and explore their roles for iron transport in placental.	Iron	190-194	solute carrier family 40 member 1	Homo sapiens	104-108
25762074-0	2015	The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.	Iron	4-8	CDGSH iron sulfur domain 1	Homo sapiens	42-50
25660235-14	2015	We concluded that suppression of Wnt/beta-catenin pathway was induced through chelating of intracellular Iron due to DFO treatment.	Iron	105-109	catenin beta 1	Homo sapiens	37-49
25713362-10	2015	The phenotype of the hepcidin knockouts was far milder, with normal survival up to 12 mo, despite far greater iron loading in the hearts.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	21-29
25756713-2	2015	Absolute iron deficiency occurs with blood losses (most common are gastro-intestinal bleedings and hemodialysis treatments) or inadequate iron absorption in the gut (mainly due to increased circulating hepcidin or treatment with erythropoiesis stimulating agents).	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	202-210
25756713-4	2015	The transmembrane iron transporter ferroportin is internalized and degraded by hepcidin with subsequent decreased iron absorption from the gut and reduced mobilization from iron storing cells.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	79-87
25756713-4	2015	The transmembrane iron transporter ferroportin is internalized and degraded by hepcidin with subsequent decreased iron absorption from the gut and reduced mobilization from iron storing cells.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	79-87
25761244-1	2015	Heme oxygenase-1 (HO-1) is a 32 kDa protein which catalyzes the breakdown of heme to free iron, carbon monoxide and biliverdin.	Iron	90-94	heme oxygenase 1	Homo sapiens	18-22
25761244-3	2015	In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial iron sequestration and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure documented in Alzheimer disease, Parkinson disease and certain neurodevelopmental conditions.	Iron	67-71	heme oxygenase 1	Homo sapiens	25-29
25761244-3	2015	In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial iron sequestration and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure documented in Alzheimer disease, Parkinson disease and certain neurodevelopmental conditions.	Iron	152-156	heme oxygenase 1	Homo sapiens	25-29
26785343-2	2015	Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling.	Iron	69-81	ceruloplasmin	Homo sapiens	0-13
26785343-2	2015	Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling.	Iron	77-81	ceruloplasmin	Homo sapiens	0-13
25594146-5	2015	RESULTS: In FSECs treated with catalytic iron for up to 6 days, we observed an increase in cell viability, NO production, and p53, pan-Ras, ERK/MAPK, PI3K/Akt, Ki67, and c-Myc activations (P &lt; 0.05) in a dose-dependent and time-dependent manner.	Iron	41-45	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	170-175
25318588-12	2015	The increased duodenal DcytB, DMT1, and FPN1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants.	Iron	79-83	solute carrier family 11 member 2	Homo sapiens	30-34
25318588-12	2015	The increased duodenal DcytB, DMT1, and FPN1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants.	Iron	79-83	solute carrier family 40 member 1	Homo sapiens	40-44
25318588-12	2015	The increased duodenal DcytB, DMT1, and FPN1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants.	Iron	112-116	solute carrier family 40 member 1	Homo sapiens	40-44
25520048-8	2015	Decreased levels of adiponectin, macrophage-mediated inflammation, and ROS-mediated liver kinase B1 (LKB1)/adenosine monophosphate-activated protein kinase (AMPK) activation can contribute to iron overload-induced insulin resistance, whereas iron deficiency could also participate in obesity-related inflammation, hypoxia, and insulin resistance.	Iron	192-196	adiponectin, C1Q and collagen domain containing	Mus musculus	20-31
25716857-0	2015	Parkinson"s disease iron deposition caused by nitric oxide-induced loss of beta-amyloid precursor protein.	Iron	20-24	amyloid beta (A4) precursor protein	Mus musculus	75-105
25716857-2	2015	We reported previously that the Alzheimer-associated beta-amyloid precursor protein (APP) facilitates neuronal iron export.	Iron	111-115	amyloid beta (A4) precursor protein	Mus musculus	53-83
25519735-1	2015	Under conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic cells.	Iron	176-180	erythropoietin	Mus musculus	57-71
25519735-1	2015	Under conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic cells.	Iron	176-180	erythropoietin	Mus musculus	73-76
25519735-1	2015	Under conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic cells.	Iron	215-219	erythropoietin	Mus musculus	57-71
25519735-1	2015	Under conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic cells.	Iron	215-219	erythropoietin	Mus musculus	73-76
25519735-5	2015	Epo treatment also resulted in liver iron mobilization, mediated by increased ferroportin activity and accompanied by reduced ferritin levels and increased TfR1 expression.	Iron	37-41	erythropoietin	Mus musculus	0-3
25499454-9	2015	We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo sensitivity.	Iron	47-51	erythropoietin	Mus musculus	176-179
25758857-1	2015	Recently an early onset lethal encephalopathy has been described in relation to mutations of NFU1, one of the genes involved in iron-sulfur cluster metabolism.	Iron	128-132	NFU1 iron-sulfur cluster scaffold	Homo sapiens	93-97
25647178-1	2015	Increased serum ferritin associated with mild hepatic iron accumulation, despite preserved upregulation of the iron hormone hepcidin, is frequently observed in patients with dysmetabolic overload syndrome (DIOS).	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	124-132
25647178-5	2015	Hepatic iron accumulation was paralleled by induction of ferritin, in the presence of preserved upregulation of hepcidin, recapitulating the features of DIOS.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	112-120
25345697-0	2015	Sustained improvements in myocardial T2* over 2 years in severely iron-overloaded patients with beta thalassemia major treated with deferasirox or deferoxamine.	Iron	66-70	brachyury 2	Mus musculus	37-39
25345697-4	2015	Improved mT2* with deferasirox was evident across all subgroups evaluated irrespective of baseline myocardial (mT2* &lt; 10 vs. &gt;= 10 ms) or liver (LIC &lt;15 vs. &gt;=15 mg Fe/g dw) iron burden.	Iron	186-190	brachyury 2	Mus musculus	9-12
25483413-0	2015	Evaluation of the effect of divalent metal transporter 1 gene polymorphism on blood iron, lead and cadmium levels.	Iron	84-88	solute carrier family 11 member 2	Homo sapiens	28-56
25483413-1	2015	Divalent metal transporter 1 (DMT1), a member of the proton-coupled metal ion transporter family, mediates transport of ferrous iron from the lumen of the intestine into the enterocyte and export of iron from endocytic vesicles.	Iron	128-132	solute carrier family 11 member 2	Homo sapiens	0-28
25483413-1	2015	Divalent metal transporter 1 (DMT1), a member of the proton-coupled metal ion transporter family, mediates transport of ferrous iron from the lumen of the intestine into the enterocyte and export of iron from endocytic vesicles.	Iron	128-132	solute carrier family 11 member 2	Homo sapiens	30-34
25483413-1	2015	Divalent metal transporter 1 (DMT1), a member of the proton-coupled metal ion transporter family, mediates transport of ferrous iron from the lumen of the intestine into the enterocyte and export of iron from endocytic vesicles.	Iron	199-203	solute carrier family 11 member 2	Homo sapiens	0-28
25483413-1	2015	Divalent metal transporter 1 (DMT1), a member of the proton-coupled metal ion transporter family, mediates transport of ferrous iron from the lumen of the intestine into the enterocyte and export of iron from endocytic vesicles.	Iron	199-203	solute carrier family 11 member 2	Homo sapiens	30-34
25483413-5	2015	To study the possible association of DMT1 gene with the blood levels of some divalent cations such as iron, lead and cadmium, a single nucleotide polymorphism (SNP) (IVS4+44C/A) in DMT1 gene was investigated in 486 unrelated and healthy individuals in a Turkish population by method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).	Iron	102-106	solute carrier family 11 member 2	Homo sapiens	37-41
25483413-9	2015	Highly statistically significant associations were detected between IVS4+44 C/A polymorphism in the DMT1 gene and iron and lead levels (p=0.001 and p=0.036, respectively), but no association was found with cadmium level (p=0.344).	Iron	114-118	solute carrier family 11 member 2	Homo sapiens	100-104
25483413-10	2015	This study suggested that DMT1 IVS4+44 C/A polymorphism is associated with inter-individual variations in blood iron, lead and cadmium levels.	Iron	112-116	solute carrier family 11 member 2	Homo sapiens	26-30
25525212-2	2015	Considering that reduced serum iron is caused by increased erythropoiesis, insufficient reabsorption, or elevated hepcidin levels, one might speculate that exaggerated HPV in high-altitude pulmonary edema (HAPE) is related to low serum iron.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	114-122
25388433-5	2015	Additional biochemical and genetic analyses identified Nfu as an Fe-S cluster carrier, which aids in the maturation of Fe-S proteins.	Iron	65-69	NFU1 iron-sulfur cluster scaffold	Homo sapiens	55-58
25388433-5	2015	Additional biochemical and genetic analyses identified Nfu as an Fe-S cluster carrier, which aids in the maturation of Fe-S proteins.	Iron	119-123	NFU1 iron-sulfur cluster scaffold	Homo sapiens	55-58
25388433-7	2015	A nfu mutant accumulates both increased intracellular non-incorporated Fe and endogenous reactive oxygen species (ROS) resulting in DNA damage.	Iron	71-73	NFU1 iron-sulfur cluster scaffold	Homo sapiens	2-5
25592008-9	2015	CONCLUSION: When infants who were exclusively breastfed were supplemented with lactoferrin-fortified milk, significant increases in TBIC and iron absorption in the intestine were seen.	Iron	141-145	lactotransferrin	Bos taurus	79-90
25263405-10	2015	It is here (and in the duodenum) that divalent metal transporter 1 (DMT1), which is primarily responsible for the passage of iron (or uranium?)	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	38-66
25263405-10	2015	It is here (and in the duodenum) that divalent metal transporter 1 (DMT1), which is primarily responsible for the passage of iron (or uranium?)	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	68-72
25765800-0	2015	[Two novel potential markers for iron metabolism: hepcidin and non-transferrin-bound iron (NTBI)].	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	50-58
25765800-9	2015	In this review, the iron regulatory peptide-hormone hepcidin and non-transferrin-bound iron (NTBI) are introduced as novel potential biomarkers for iron metabolism.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	52-60
25519750-6	2015	In moderate disease, no independent predictors of hepcidin were identifiable; nevertheless, the low hepcidin levels indicate a significant risk for iron overload.	Iron	148-152	hepcidin antimicrobial peptide	Homo sapiens	100-108
25519750-8	2015	In summary, the influence of erythropoiesis on hepcidin suppression associates with phenotypic disease variation and pathogenesis in HbE beta-thalassemia and indicates that the epidemiology of beta-thalassemia trait requires consideration when planning public health iron interventions.	Iron	267-271	hepcidin antimicrobial peptide	Homo sapiens	47-55
25646159-5	2014	Hepcidin has been identified to be a central regulator of iron absorption from the intestine and of iron plasma levels.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
25646159-5	2014	Hepcidin has been identified to be a central regulator of iron absorption from the intestine and of iron plasma levels.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-8
25378535-4	2015	Subsequent gene set enrichment analysis showed that many genes associated with the high iron cluster were involved in the toll-like receptor system (TLR4, TLR7, and TLR8) and inflammasome complex pathway (NLRP3, NLRC4, and CASP1).	Iron	88-92	toll like receptor 4	Homo sapiens	149-153
25378496-9	2015	Taken together, these results suggest that PK1 prevents apoferritin from iron loading, and thus stabilizes the cellular LIP levels, and that WSSV uses this novel mechanism to counteract the host cell"s iron-withholding defense mechanism.	Iron	73-77	ferritin heavy chain 1	Homo sapiens	56-67
25370199-2	2015	Although recombinant human apoferritin (HuFtH) rapidly oxidizes Fe(II) to Fe(III) , this iron is not properly stored in the ferritin cavity, as otherwise occurs in horse-spleen H/L-apoferritin (HsFt; H=heavy subunit, L=light subunit).	Iron	89-93	ferritin heavy chain 1	Homo sapiens	27-38
25574604-2	2015	We wanted to evaluate whether a functional polymorphism in the HMOX1 gene encoding heme oxygenase modifies risk of CRC or interacts with diet or lifestyle factors because this would identify heme or heme iron as a risk factor of CRC.	Iron	204-208	heme oxygenase 1	Homo sapiens	63-68
25541274-12	2015	Thus, monitoring of the dose of iron chelators, according to the type of mutation in the beta globin gene, may help improve the compliance of beta thalassemics to chelation therapy and prevent side-effects in patients with beta plus mutations.	Iron	32-36	hemoglobin subunit beta	Homo sapiens	89-100
25205713-1	2015	Matriptase-2 is a type II transmembrane serine protease controlling the expression of hepcidin, the key regulator of iron homeostasis.	Iron	117-121	transmembrane protease, serine 11e	Mus musculus	18-55
25460199-9	2015	In conclusion, iron accumulation induces NGF expression in hepatocytes, which in turn leads to LSEC defenestration via TrkA.	Iron	15-19	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	119-123
26202365-0	2015	Thrombopoietin Protects Cardiomyocytes from Iron-Overload Induced Oxidative Stress and Mitochondrial Injury.	Iron	44-48	thrombopoietin like 1	Rattus norvegicus	0-14
26202365-11	2015	TPO exerted a cardio-protective effect on iron-induced apoptosis.	Iron	42-46	thrombopoietin like 1	Rattus norvegicus	0-3
26202365-13	2015	TPO might exert a protective effect on iron-overload induced apoptosis via inhibiting oxidative stress and suppressing the mitochondrial pathways in cardiomyocytes.	Iron	39-43	thrombopoietin like 1	Rattus norvegicus	0-3
25413113-1	2015	Nanoparticles of iron and potassium diphosphate (KFeP2O7) implanted in silica gel beads (SiO2) have been investigated as an alternative adsorbent for removing Cd2+ ions from aqueous solutions.	Iron	17-21	CD2 molecule	Homo sapiens	159-162
26496240-1	2015	OBJECTIVE: Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	11-19
25300398-11	2015	Administration of exogenous BMP7 was effective in correcting the plasma iron level and bone loss, indicating that BMP6 is an essential but not exclusive in vivo regulator of iron homeostasis.	Iron	72-76	bone morphogenetic protein 6	Mus musculus	114-118
24659514-1	2015	BACKGROUND: Hepcidin is a peptide hormone that plays a key role in regulating iron absorption from the small intestine and body iron distribution.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	12-20
24659514-1	2015	BACKGROUND: Hepcidin is a peptide hormone that plays a key role in regulating iron absorption from the small intestine and body iron distribution.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	12-20
26160488-8	2015	Functional iron deficiency was associated with significantly higher serum levels of fibrinogen, ferritin, transferrin saturation, total iron binding capacity, hepcidin and older age relative to patients with absolute iron deficiency.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	159-167
25564462-0	2015	Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells.	Iron	52-56	heat shock protein 90 alpha family class A member 1	Homo sapiens	32-37
26374719-4	2015	Chronic inflammation in CKD increases the production of hepcidin, which blocks iron absorption from the intestine and leads to less efficient re-use of iron from the macrophages.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	56-64
26374719-4	2015	Chronic inflammation in CKD increases the production of hepcidin, which blocks iron absorption from the intestine and leads to less efficient re-use of iron from the macrophages.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	56-64
26946556-2	2015	Hepcidin plays the key role in iron metabolism, as protein participating in the regulation of intestinal absorption of this element and its release from macrophages, and transport across the placenta.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
26946556-4	2015	The depletion of maternal iron can cause fetal hypoxia condition and decreased expression of hepcidin.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	93-101
25579711-3	2015	The present study was directed to investigate serum levels of hepcidin, iron status and inflammation markers such as C-reactive protein (CRP) in patients with ESRD on maintenance HD and to observe the correlation of serum hepcidin with conventional iron and inflammatory markers.	Iron	249-253	hepcidin antimicrobial peptide	Homo sapiens	222-230
25579713-1	2015	Hepcidin prevents absorption of iron from the intestine and inhibits release of iron from macrophages and hepatocytes.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
25579713-1	2015	Hepcidin prevents absorption of iron from the intestine and inhibits release of iron from macrophages and hepatocytes.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
25742771-1	2015	Hepcidin is a key regulator of mammalian iron metabolism and mainly produced by the liver.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
25742771-2	2015	Hepcidin excess causes iron deficiency and anemia by inhibiting iron absorption from the intestine and iron release from macrophage stores.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
25742771-2	2015	Hepcidin excess causes iron deficiency and anemia by inhibiting iron absorption from the intestine and iron release from macrophage stores.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
26852537-8	2015	In individuals with the AA genotype rs9939609 FTO gene compared with the TT genotype had significantly lower levels of HDL cholesterol and serum iron in the background significantly elevated concentrations of uric acid.	Iron	145-149	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	46-49
25469461-0	2014	Influence of redox reactive iron, lactate, and succinate on the myoglobin redox stability and mitochondrial respiration.	Iron	28-32	myoglobin	Homo sapiens	64-73
25469461-2	2014	Inorganic redox reactive iron (RRI) forms are pro-oxidants that have been shown to oxidize myoglobin in model systems.	Iron	25-29	myoglobin	Homo sapiens	91-100
25565811-4	2015	METHODS: Iron-tagged SWCNTs conjugated with Endoglin/CD105 antibody with or without DOX were synthetized and extensively characterized.	Iron	9-13	endoglin	Mus musculus	44-52
25565811-4	2015	METHODS: Iron-tagged SWCNTs conjugated with Endoglin/CD105 antibody with or without DOX were synthetized and extensively characterized.	Iron	9-13	endoglin	Mus musculus	53-58
25506921-9	2014	Age, gender (female sex) and the hepcidin level also influenced liver iron content on MRI.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	33-41
25464026-1	2014	Ceruloplasmin is a ferroxidase that interacts with ferroportin to export cellular iron, but is not expressed in neurons.	Iron	82-86	ceruloplasmin	Homo sapiens	0-13
25127743-2	2014	Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes.	Iron	21-25	solute carrier family 11 member 2	Homo sapiens	173-180
25433101-0	2014	[Effect of hepcidin on iron metabolism in athletes].	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	11-19
25240856-3	2014	Ind1, an iron-sulfur cluster protein involved in the maturation of respiratory complex and binds an Fe/S cluster via a conserved CXXC motif in a labile way.	Iron	9-13	NUBP iron-sulfur cluster assembly factor, mitochondrial	Homo sapiens	0-4
25473172-9	2014	Ribavirin-induced hemolysis floods the hepatocytes and KCs with heme, which is metabolized and detoxified by heme oxygenase-1 (HMOX1) to carbon monoxide (CO), biliverdin and free iron (which induces ferritin).	Iron	179-183	heme oxygenase 1	Homo sapiens	127-132
25239913-8	2014	Additionally, sequestration of excess iron using iron chelators resulted in increased hypoxia response element response in CFBE41o- and 16HBE14o-, implicating a role of iron in HIF-1alpha stabilization and HO-1.	Iron	38-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	177-187
25239913-8	2014	Additionally, sequestration of excess iron using iron chelators resulted in increased hypoxia response element response in CFBE41o- and 16HBE14o-, implicating a role of iron in HIF-1alpha stabilization and HO-1.	Iron	49-53	hypoxia inducible factor 1, alpha subunit	Mus musculus	177-187
25239913-8	2014	Additionally, sequestration of excess iron using iron chelators resulted in increased hypoxia response element response in CFBE41o- and 16HBE14o-, implicating a role of iron in HIF-1alpha stabilization and HO-1.	Iron	49-53	hypoxia inducible factor 1, alpha subunit	Mus musculus	177-187
25387073-1	2014	Malus xiaojinensis iron-regulated transporter 1 (Mx IRT1) is a highly effective inducible iron transporter in the iron efficient plant Malus xiaojinensis.	Iron	19-23	IRT1	Saccharomyces cerevisiae S288C	52-56
25387073-8	2014	Taken together, data presented here provides strong evidence that an uncleaved SP determines ER-targeting of Mx IRT1 during the initial sorting stage, thereby enabling the subsequent transport and integration of this protein into the PM for its crucial role in iron uptake.	Iron	261-265	IRT1	Saccharomyces cerevisiae S288C	112-116
25277027-6	2014	Multiple transcription factors upstream of MITF were upregulated by iron.	Iron	68-72	melanocyte inducing transcription factor	Homo sapiens	43-47
25176568-4	2014	Iron metabolism is concertedly governed by the hepcidin-ferroportin axis, where hepcidin is the central hormone involved in the regulation of iron absorption and release, while ferroportin is the only known iron exporter that functions by iron egress from cells.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	47-55
25176568-4	2014	Iron metabolism is concertedly governed by the hepcidin-ferroportin axis, where hepcidin is the central hormone involved in the regulation of iron absorption and release, while ferroportin is the only known iron exporter that functions by iron egress from cells.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	80-88
25176568-4	2014	Iron metabolism is concertedly governed by the hepcidin-ferroportin axis, where hepcidin is the central hormone involved in the regulation of iron absorption and release, while ferroportin is the only known iron exporter that functions by iron egress from cells.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	47-55
25176568-4	2014	Iron metabolism is concertedly governed by the hepcidin-ferroportin axis, where hepcidin is the central hormone involved in the regulation of iron absorption and release, while ferroportin is the only known iron exporter that functions by iron egress from cells.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	80-88
25176568-4	2014	Iron metabolism is concertedly governed by the hepcidin-ferroportin axis, where hepcidin is the central hormone involved in the regulation of iron absorption and release, while ferroportin is the only known iron exporter that functions by iron egress from cells.	Iron	207-211	hepcidin antimicrobial peptide	Homo sapiens	47-55
25176568-4	2014	Iron metabolism is concertedly governed by the hepcidin-ferroportin axis, where hepcidin is the central hormone involved in the regulation of iron absorption and release, while ferroportin is the only known iron exporter that functions by iron egress from cells.	Iron	207-211	hepcidin antimicrobial peptide	Homo sapiens	47-55
25176568-8	2014	The combined data of this study identified a novel finding of CPF that disrupts iron homeostasis by altering ferroportin and hepcidin expression.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	125-133
25360591-8	2014	The seed Fe concentration in the nramp3/nramp4 mutant overexpressing AtVTL1, AtVTL2 or AtVTL5 was between 50 and 60% higher than in non-transformed double mutants or wild-type plants.	Iron	9-11	Vacuolar iron transporter (VIT) family protein	Arabidopsis thaliana	77-83
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	solute carrier family 40 member 1	Homo sapiens	105-112
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	transferrin receptor 2	Homo sapiens	118-122
24732176-3	2014	Such investigation could be important, as iron and carbon monoxide are two of the products of heme catabolism via heme oxygenase-1, an enzyme upregulated in a variety of disease states associated with thrombophilia.	Iron	42-46	heme oxygenase 1	Homo sapiens	114-130
25145495-1	2014	Hepcidin belongs to the antimicrobial peptide (AMP) family and is the key regulator of iron metabolism.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
25693393-8	2014	It increased the contents of acid-soluble and crystal Fe oxide, and the order of activity of Fe oxides was AsS1 (41.2%) treatment &gt; AsS2 (36.1%) treatment.	Iron	93-95	argininosuccinate synthase 1	Homo sapiens	107-111
24969400-1	2014	Upon cardiolipin (CL) liposomes binding, horse heart cytochrome c (cytc) changes its tertiary structure disrupting the heme-Fe-Met80 distal bond, reduces drastically the midpoint potential, binds CO and NO with high affinity, displays peroxidase activity, and facilitates peroxynitrite isomerization.	Iron	124-126	cytochrome c, somatic	Equus caballus	53-65
24663495-1	2014	Ceruloplasmin (Cp) is a serum ferroxidase that plays an essential role in iron metabolism.	Iron	74-78	ceruloplasmin	Homo sapiens	0-13
24663495-1	2014	Ceruloplasmin (Cp) is a serum ferroxidase that plays an essential role in iron metabolism.	Iron	74-78	ceruloplasmin	Homo sapiens	15-17
25156967-2	2014	Atp7a is strongly induced in the rodent duodenum during iron deprivation, suggesting that copper influences iron homeostasis.	Iron	56-60	ATPase copper transporting alpha	Rattus norvegicus	0-5
25156967-2	2014	Atp7a is strongly induced in the rodent duodenum during iron deprivation, suggesting that copper influences iron homeostasis.	Iron	108-112	ATPase copper transporting alpha	Rattus norvegicus	0-5
25222273-4	2014	It showed structural similarities to native monomeric iron free (Apo) lactoferrin (~78-80 kDa), retained anti-bovine lactoferrin antibody specific binding and displayed potential receptor binding properties when tested for cellular internalization.	Iron	54-58	lactotransferrin	Bos taurus	70-81
25017111-5	2014	Mechanisms that explain the increased risk of iron deficiency in endurance athletes, including exercise-associated inflammation and hepcidin release on iron sequestration, are described.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	132-140
25265351-8	2014	Along with it, in cell of lines of basal subtype MDA-MB-231 and MDA-MB-468, high level of FTH (254 +- 2.3 and 270 +- 1.9) is being detected in consequence of increase of level of free iron, ROS (11.3 +- 1.05 and 7.27 +- 0.26) and SOD (9.4 +- 0.24 and 8.5 +- 0.18) as well as decrease of expression of microRNA 200b.	Iron	184-188	ferritin heavy chain 1	Homo sapiens	90-93
24806658-2	2014	Although increased hepcidin, which downregulates the iron exporter ferroportin, had been incriminated, such an association has not been confirmed.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	19-27
24894955-2	2014	Hepcidin, a key regulator of iron metabolism, has been shown to be down-regulated by alcohol in cell lines and animal models.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
24894955-12	2014	The down-regulation of hepcidin expression leading to up-regulation of iron transporters expression in the duodenum seems to explain iron metabolism disturbances in ALD.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	23-31
24874645-2	2014	Since the discovery of hepcidin and the elucidation of its important role in iron homeostasis, hepcidin has been suggested as a promising diagnostic marker for iron-related disorders.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	95-103
24874645-2	2014	Since the discovery of hepcidin and the elucidation of its important role in iron homeostasis, hepcidin has been suggested as a promising diagnostic marker for iron-related disorders.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	95-103
24880337-4	2014	The opt3-2 mutant constitutively up-regulates the Fe/Zn/Cd transporter IRT1 and FRO2 in roots, indicative of an iron-deficiency response.	Iron	112-116	IRT1	Saccharomyces cerevisiae S288C	71-75
24880337-6	2014	Interestingly, shoot-specific expression of OPT3 rescues the Cd sensitivity and complements the aberrant expression of IRT1 in opt3-2 roots, suggesting that OPT3 is required to relay the iron status from leaves to roots.	Iron	187-191	IRT1	Saccharomyces cerevisiae S288C	119-123
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	35-39	YELLOW STRIPE like 2	Arabidopsis thaliana	91-95
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	41-43	YELLOW STRIPE like 2	Arabidopsis thaliana	91-95
25162662-6	2014	Moreover, this marker was about 200 kb away from the candidate gene SLC40A1 which is responsible for iron export.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	68-75
25002578-1	2014	Systemic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally regulated by the bone morphogenetic protein (BMP)-SMAD pathway.	Iron	9-13	SMAD family member 4	Mus musculus	152-156
25002578-2	2014	In iron deficiency, liver BMP-SMAD signaling and hepcidin are suppressed as a compensatory mechanism to increase iron availability.	Iron	3-7	SMAD family member 4	Mus musculus	30-34
25002578-10	2014	Our data suggest that iron deficiency increases liver miR-130a, which, by targeting ALK2, may contribute to reduce BMP-SMAD signaling, suppress hepcidin synthesis, and thereby promote iron availability.	Iron	22-26	SMAD family member 4	Mus musculus	119-123
25313323-2	2014	We report here the crystal structures of two IDO1/IDO1 inhibitor complexes, one of which shows that Amg-1 is directly bound to the heme iron of IDO1 with a clear induced fit.	Iron	136-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	45-49
25313323-2	2014	We report here the crystal structures of two IDO1/IDO1 inhibitor complexes, one of which shows that Amg-1 is directly bound to the heme iron of IDO1 with a clear induced fit.	Iron	136-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	50-54
25313323-2	2014	We report here the crystal structures of two IDO1/IDO1 inhibitor complexes, one of which shows that Amg-1 is directly bound to the heme iron of IDO1 with a clear induced fit.	Iron	136-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	50-54
24854545-9	2014	These results indicate that ferrous iron imported by DMT1 is transferred directly to PCBP2.	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	53-57
24854545-11	2014	These findings suggest that PCBP2 can transfer ferrous iron from DMT1 to the appropriate intracellular sites or ferroportin and could function as an iron chaperone.	Iron	55-59	solute carrier family 11 member 2	Homo sapiens	65-69
24994858-5	2014	Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	109-113
24994858-5	2014	Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	202-210
24994858-6	2014	Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
24994858-6	2014	Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation.	Iron	30-34	solute carrier family 40 member 1	Homo sapiens	78-91
24994858-6	2014	Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	0-8
24994858-6	2014	Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation.	Iron	64-68	solute carrier family 40 member 1	Homo sapiens	78-91
24994858-7	2014	Mucosal regulation of iron transport also occurs during low-iron states, via transcriptional (by hypoxia-inducible factor 2alpha) and posttranscriptional (by the iron-sensing iron-regulatory protein/iron-responsive element system) mechanisms.	Iron	22-26	endothelial PAS domain protein 1	Homo sapiens	97-128
25117470-4	2014	As shown by a comparative two dimensional difference gel electrophoresis (2D-DIGE) approach combined with mass spectrometry, particularly two groups of proteins were affected: the iron-sulfur containing aconitase-type proteins (Aco1p, Lys4p) and the lipoamide-containing subproteome (Lat1p, Kgd2p and Gcv3p).	Iron	180-184	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	235-240
24953342-2	2014	Here we extend this narrative by demonstrating their utility in affording access to the first examples of two-coordinate formal Fe(0) and Co(0) [(CAAC)2M] complexes, prepared by reduction of their corresponding two-coordinate cationic Fe(I) and Co(I) precursors.	Iron	128-133	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	245-250
24781685-0	2014	The value of Ret-Hb and sTfR in the diagnosis of iron depletion in healthy, young children.	Iron	49-53	ret proto-oncogene	Homo sapiens	13-16
24781685-1	2014	OBJECTIVES: Reticulocyte hemoglobin (Ret-Hb) content and soluble transferrin receptor (sTfR) are described as promising biomarkers in the analysis of iron status.	Iron	150-154	ret proto-oncogene	Homo sapiens	12-15
24781685-3	2014	We hypothesized that young children to iron depletion, using the WHO cutoff of ferritin &lt;12 mug/l, would have lower Ret-Hb and higher sTfR concentrations compared to children with a ferritin &gt;=level 12 mug/l.	Iron	39-43	ret proto-oncogene	Homo sapiens	119-122
24781685-6	2014	RESULTS: We showed that concentrations of Ret-Hb and sTfR are similar in children with and without iron depletion.	Iron	99-103	ret proto-oncogene	Homo sapiens	42-45
24781685-9	2014	CONCLUSIONS: Our results showed that the discriminative value of Ret-Hb and sTfR for the detection of iron depletion is limited.	Iron	102-106	ret proto-oncogene	Homo sapiens	65-68
24773038-5	2014	By application of sodium azide, ethylenediaminetetraacetic acid, sodium dodecylsulphate, varying temperature, and spiking endogenous substances we demonstrate that in the case of mammalian sera the assay determines ceruloplasmin (CP) activity with potential interferences from hydroperoxides, iron level, thiols, and albumin.	Iron	293-297	ceruloplasmin	Homo sapiens	215-228
24857540-1	2014	Hepcidin produced in the liver negatively regulates intestinal iron absorption, and the bone morphogenetic protein (BMP) pathway is well-known to stimulate hepcidin expression.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
25044383-2	2014	Patients with inflammation respond less well to treatment with erythropoietin, possibly because the increased production of hepcidin reduces the availability of iron for hematopoiesis.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	124-132
24931767-11	2014	Deferoxamine and iron may modulate CD47 expression.	Iron	17-21	CD47 molecule	Sus scrofa	35-39
25047818-9	2014	CONCLUSIONS: These results indicate that the metabolic response to HTG in human apolipoprotein C-III overexpressing mice may support a high TG production rate and that the cytosol of hepatocytes is subjected to an important oxidative stress, probably as a result of FFA over-accumulation, iron overload and enhanced activity of some ROS-producing catabolic enzymes.	Iron	289-293	apolipoprotein C3	Homo sapiens	80-100
24556216-5	2014	Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.	Iron	29-33	transferrin receptor 2	Homo sapiens	66-70
24556216-5	2014	Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.	Iron	29-33	patatin like phospholipase domain containing 3	Homo sapiens	119-125
25011704-3	2014	Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export.	Iron	0-4	ceruloplasmin	Mus musculus	51-64
25011704-3	2014	Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export.	Iron	0-4	ceruloplasmin	Mus musculus	66-68
25011704-3	2014	Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export.	Iron	95-99	ceruloplasmin	Mus musculus	51-64
25011704-3	2014	Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export.	Iron	95-99	ceruloplasmin	Mus musculus	66-68
25011704-4	2014	We previously showed that ceruloplasmin knockout (CP KO) mice exhibit Parkinsonian neurodegeneration (~30% nigral loss) by 6 months, which is prevented by iron chelation.	Iron	155-159	ceruloplasmin	Mus musculus	26-39
25011704-4	2014	We previously showed that ceruloplasmin knockout (CP KO) mice exhibit Parkinsonian neurodegeneration (~30% nigral loss) by 6 months, which is prevented by iron chelation.	Iron	155-159	ceruloplasmin	Mus musculus	50-52
25011704-5	2014	Here, we explored whether known iron-stressors of the SN (1) aging and (2) MPTP, would exaggerate the lesion severity of CP KO mice.	Iron	32-36	ceruloplasmin	Mus musculus	121-123
25011704-7	2014	Unlike young mice, iron chelation therapy in CP KO mice between 9-14 months did not rescue neuronal loss.	Iron	19-23	ceruloplasmin	Mus musculus	45-47
25006697-4	2014	Specifically, we will focus on heme peroxidases, metallo-beta-lactamases, alpha-synuclein and ligase ribozymes to show how this approach is capable of describing the catalytic and/or structural role played by transition (Fe, Zn or Cu) and main group (Mg) metals.	Iron	221-223	synuclein alpha	Homo sapiens	74-89
24269922-2	2014	The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1beta.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
24269922-13	2014	Serum levels of hepcidin were lower in iron-deficient subjects, reflecting an appropriate physiologic response to decreased circulating levels of iron, rather than a primary cause of iron deficiency in the setting of obesity and NAFLD.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	16-24
24269922-13	2014	Serum levels of hepcidin were lower in iron-deficient subjects, reflecting an appropriate physiologic response to decreased circulating levels of iron, rather than a primary cause of iron deficiency in the setting of obesity and NAFLD.	Iron	146-150	hepcidin antimicrobial peptide	Homo sapiens	16-24
24746839-7	2014	Caco-2 cells were exposed to 0, 80 and 120 muM Fe and responded with increased hepcidin production at 120 muM Fe (3.6+-0.3 ng/ml compared to 2.7+-0.3 ng/ml).	Iron	47-49	hepcidin antimicrobial peptide	Homo sapiens	79-87
24746839-7	2014	Caco-2 cells were exposed to 0, 80 and 120 muM Fe and responded with increased hepcidin production at 120 muM Fe (3.6+-0.3 ng/ml compared to 2.7+-0.3 ng/ml).	Iron	110-112	hepcidin antimicrobial peptide	Homo sapiens	79-87
24746839-8	2014	The expression of iron exporter ferroportin in Caco-2 cells was decreased at the hepcidin concentration of 3.6 ng/ml and undetectable at external addition of hepcidin (10 ng/ml).	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	81-89
24746839-8	2014	The expression of iron exporter ferroportin in Caco-2 cells was decreased at the hepcidin concentration of 3.6 ng/ml and undetectable at external addition of hepcidin (10 ng/ml).	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	158-166
24585548-4	2014	Exposure to (56)Fe (600 MeV; 0.1, 0.2 and 0.4 Gy) resulted in minor pro-fibrotic changes, detected at the beginning of the fibrotic phase (22 weeks post exposure), which were exhibited as increased expression of chemokine Ccl3, and interleukin Il4.	Iron	16-18	chemokine (C-C motif) ligand 3	Mus musculus	222-226
24585548-4	2014	Exposure to (56)Fe (600 MeV; 0.1, 0.2 and 0.4 Gy) resulted in minor pro-fibrotic changes, detected at the beginning of the fibrotic phase (22 weeks post exposure), which were exhibited as increased expression of chemokine Ccl3, and interleukin Il4.	Iron	16-18	interleukin 4	Mus musculus	244-247
24742827-1	2014	Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer (TNBC) patients.	Iron	95-99	ferritin heavy chain 1	Homo sapiens	0-20
24742827-1	2014	Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer (TNBC) patients.	Iron	95-99	ferritin heavy chain 1	Homo sapiens	22-26
24566273-3	2014	Hepcidin, a peptide hormone, has been recognized as a biomarker for iron-related diseases.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	0-8
24727792-0	2014	Expression of peanut Iron Regulated Transporter 1 in tobacco and rice plants confers improved iron nutrition.	Iron	94-98	probable zinc transporter 10	Nicotiana tabacum	21-49
24727792-2	2014	Iron Regulated Transporter 1 (IRT1) is a key component for Fe uptake from the soil in dicot plants.	Iron	59-61	probable zinc transporter 10	Nicotiana tabacum	0-28
24727792-2	2014	Iron Regulated Transporter 1 (IRT1) is a key component for Fe uptake from the soil in dicot plants.	Iron	59-61	probable zinc transporter 10	Nicotiana tabacum	30-34
24978810-0	2014	The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	16-24
24978810-6	2014	Patients with absolute iron deficiency (transferrin saturation (TSAT) &lt;20% and ferritin &lt;40 ng/mL) had the lowest hepcidin levels (5.0 ng/mL [0.7-11.7]), and those with a normal iron profile (TSAT &gt;=20% and ferritin &gt;=40), the highest (34.5 ng/mL [23.7-51.6]).	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	120-128
24978810-7	2014	In multivariate analysis, absolute iron deficiency was associated with lower hepcidin values, and inflammation combined with a normal or functional iron profile with higher values, independent of other determinants of hepcidin concentration, including EPO, mGFR, and albuminemia.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	77-85
24978810-9	2014	There was a significant interaction with iron status in the association between Hb and hepcidin.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	87-95
24896847-0	2014	The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.	Iron	59-63	ceruloplasmin	Mus musculus	16-27
24896847-1	2014	Hephaestin is a vertebrate multicopper ferroxidase important for the transfer of dietary iron from intestinal cells to the blood.	Iron	89-93	ceruloplasmin	Mus musculus	39-50
24798798-0	2014	Structure of the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut.	Iron	17-21	lactotransferrin	Bos taurus	58-69
24798798-9	2014	The structure determination revealed that the iron atom was absent and the iron-binding cleft was found in a wide-open conformation, whereas in the previously determined structure of iron-saturated C-lobe of bovine lactoferrin, the iron atom was present and the iron-binding site was in the closed confirmation.	Iron	46-50	lactotransferrin	Bos taurus	215-226
24798798-9	2014	The structure determination revealed that the iron atom was absent and the iron-binding cleft was found in a wide-open conformation, whereas in the previously determined structure of iron-saturated C-lobe of bovine lactoferrin, the iron atom was present and the iron-binding site was in the closed confirmation.	Iron	75-79	lactotransferrin	Bos taurus	215-226
24798798-9	2014	The structure determination revealed that the iron atom was absent and the iron-binding cleft was found in a wide-open conformation, whereas in the previously determined structure of iron-saturated C-lobe of bovine lactoferrin, the iron atom was present and the iron-binding site was in the closed confirmation.	Iron	75-79	lactotransferrin	Bos taurus	215-226
24798798-9	2014	The structure determination revealed that the iron atom was absent and the iron-binding cleft was found in a wide-open conformation, whereas in the previously determined structure of iron-saturated C-lobe of bovine lactoferrin, the iron atom was present and the iron-binding site was in the closed confirmation.	Iron	75-79	lactotransferrin	Bos taurus	215-226
24798798-9	2014	The structure determination revealed that the iron atom was absent and the iron-binding cleft was found in a wide-open conformation, whereas in the previously determined structure of iron-saturated C-lobe of bovine lactoferrin, the iron atom was present and the iron-binding site was in the closed confirmation.	Iron	75-79	lactotransferrin	Bos taurus	215-226
25076763-12	2014	However, hepcidin concentration was slightly higher in the iron replete-group than in the iron-deficient group (45.2 +/- 20.0 and 39.3 +/- 13.5 ng/mL, respectively), a suggestive trend that did not reach statistical significance (p = .218).	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	9-17
25076763-13	2014	CONCLUSIONS: Hepcidin concentrations tended to be higher among the subset of girls who responded poorly to iron supplementation as a consequence of increased subclinical inflammation.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	13-21
25076763-14	2014	A longitudinal study should be conducted to explore the role of hepcidin in iron supplementation.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	64-72
24746831-0	2014	Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway.	Iron	35-39	bone morphogenetic protein 6	Mus musculus	84-88
24746831-0	2014	Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway.	Iron	35-39	SMAD family member 4	Mus musculus	89-94
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Iron	31-35	bone morphogenetic protein 6	Mus musculus	94-98
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Iron	31-35	SMAD family member 4	Mus musculus	99-104
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Iron	72-76	bone morphogenetic protein 6	Mus musculus	94-98
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Iron	72-76	SMAD family member 4	Mus musculus	99-104
24286977-0	2014	Low hepcidin triggers hepatic iron accumulation in patients with hepatitis C. Persistent hepatitis C virus (HCV) infection is a major cause of chronic liver disease including fibrosis, cirrhosis and hepatocellular carcinoma (HCC).	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	4-12
24286977-7	2014	If hepcidin is also low in CKD patients with CHC, iron supplementation should be avoided even in CKD patients with CHC treated with erythropoiesis-stimulating agents.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	3-11
24921009-0	2014	Ceruloplasmin-ferroportin system of iron traffic in vertebrates.	Iron	36-40	ceruloplasmin	Homo sapiens	0-13
24921009-2	2014	While many proteins involved in iron uptake by cells are known, only one cellular iron export protein has been identified in mammals: ferroportin (SLC40A1).	Iron	82-86	solute carrier family 40 member 1	Homo sapiens	147-154
24921009-4	2014	According to the currently accepted view, ferrous iron transported out of the cell by ferroportin would be safely oxidized by ceruloplasmin to facilitate loading on transferrin.	Iron	42-54	ceruloplasmin	Homo sapiens	126-139
24921009-5	2014	Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for physiological regulation of cellular iron levels.	Iron	89-93	ceruloplasmin	Homo sapiens	15-28
24921009-5	2014	Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for physiological regulation of cellular iron levels.	Iron	164-168	ceruloplasmin	Homo sapiens	15-28
24855192-0	2014	The iron fist: malaria and hepcidin.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	27-35
24832443-1	2014	The hormone hepcidin promotes iron sequestration by macrophages.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	12-20
24860505-0	2014	Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis.	Iron	62-66	hemojuvelin BMP co-receptor	Homo sapiens	0-11
24860505-0	2014	Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis.	Iron	62-66	bone morphogenetic protein 1	Homo sapiens	16-42
24860505-0	2014	Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis.	Iron	62-66	bone morphogenetic protein 1	Homo sapiens	44-47
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	197-201	hemojuvelin BMP co-receptor	Homo sapiens	19-22
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	197-201	bone morphogenetic protein 1	Homo sapiens	58-84
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	197-201	bone morphogenetic protein 1	Homo sapiens	86-89
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	197-201	hepcidin antimicrobial peptide	Homo sapiens	210-218
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	246-250	hemojuvelin BMP co-receptor	Homo sapiens	19-22
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	246-250	bone morphogenetic protein 1	Homo sapiens	58-84
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	246-250	bone morphogenetic protein 1	Homo sapiens	86-89
24860505-2	2014	The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis.	Iron	246-250	hepcidin antimicrobial peptide	Homo sapiens	210-218
24860505-4	2014	This review also explores the interaction between HJV, the BMP-SMAD signaling pathway and other regulators of hepcidin expression in systemic iron balance.	Iron	142-146	bone morphogenetic protein 1	Homo sapiens	59-62
24860505-4	2014	This review also explores the interaction between HJV, the BMP-SMAD signaling pathway and other regulators of hepcidin expression in systemic iron balance.	Iron	142-146	hepcidin antimicrobial peptide	Homo sapiens	110-118
24533562-0	2014	Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	168-176
24533562-6	2014	Inappropriately low levels of hepcidin with respect to iron loading were detected in all PK-deficient patients with increased ferritin, confirming the predominant effect of accelerated erythropoiesis on hepcidin production.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	30-38
24448823-10	2014	We suggest that DMT1 not only exports iron from endosomes, but also serves to import the metal into the mitochondria.	Iron	38-42	solute carrier family 11 member 2	Homo sapiens	16-20
24673886-4	2014	Physiologically, depletion of the mammalian siderophore by inhibiting expression of the 3-hydroxybutyrate dehydrogenase-2 gene (Bdh2) results in abnormal accumulation of intracellular iron, increased oxidative stress, and mitochondrial iron deficiency.	Iron	184-188	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	128-132
25055699-3	2014	Among them 5% Fe/Ce-Lap presented the best activity at 180 degreeC and the maximum sulfur yield was up to 96% due to the interaction between iron and cerium, which improved the redox ability of Fe3+ .	Iron	141-145	LAP	Homo sapiens	20-23
23751596-2	2014	Type 2 transferrin receptor (TFR2) participates in cellular iron overload and is related to cardiovascular disease.	Iron	60-64	transferrin receptor 2	Homo sapiens	29-33
24573684-2	2014	Initially, the Fe-S clusters are assembled on a conserved scaffold protein, iron-sulfur cluster scaffold protein (ISCU), in coordination with iron and sulfur donor proteins in human mitochondria.	Iron	15-19	NFU1 iron-sulfur cluster scaffold	Homo sapiens	76-112
24573684-7	2014	The biochemical results highlight that the G50E mutation results in compromised interaction with the sulfur donor NFS1 and the J-protein HSCB, thus impairing the rate of Fe-S cluster synthesis.	Iron	170-174	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	137-141
23905873-1	2014	OBJECTIVE: Hepcidin is a key regulator of body iron homeostasis.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	11-19
24584909-3	2014	To date, only homozygous or compound heterozygous states of HJV gene have been reported as associated with iron overload.	Iron	107-111	hemojuvelin BMP co-receptor	Homo sapiens	60-63
24734754-5	2014	In addition, we applied a ferritin/apoferritin blended monolayer to the study of iron mineralization and revealed that biomineralization in this system is spatially selective.	Iron	81-85	ferritin heavy chain 1	Homo sapiens	35-46
24103305-0	2014	In vivo MRI detection of carotid atherosclerotic lesions and kidney inflammation in ApoE-deficient mice by using LOX-1 targeted iron nanoparticles.	Iron	128-132	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	113-118
24553975-5	2014	Serum TNF-alpha concentration was also statistically significantly correlated with FE(Na(+)) (r = 0.7056), UCr/SCr (r = -0.8199), USG (r = -0.8075) and duration of the disease (r = 0.6767).	Iron	83-86	tumor necrosis factor	Canis lupus familiaris	6-15
24111973-5	2014	Treatment with ABA also led to increased Fe concentrations in the xylem sap, partially because of the up-regulation of AtFRD3, AtYSL2 and AtNAS1, genes related to long-distance transport of Fe.	Iron	190-192	YELLOW STRIPE like 2	Arabidopsis thaliana	127-133
24631590-0	2014	Novel role of the Candida albicans ferric reductase gene CFL1 in iron acquisition, oxidative stress tolerance, morphogenesis and virulence.	Iron	65-69	cofilin 1, non-muscle	Mus musculus	57-61
24631590-3	2014	However, deletion of CFL1 increased cellular iron accumulation by elevating surface ferric reductase activity in Candida albicans, revealing that there existed functional redundancy and/or a compensatory upregulation mechanism among ferric reductase genes.	Iron	45-49	cofilin 1, non-muscle	Mus musculus	21-25
24631590-7	2014	Moreover, deletion of CFL1 led to a profound defect in filamentous development in an iron-independent manner at both 30 and 37  C. The cfl1Delta/Delta mutant exhibited highly attenuated virulence and reduced fungal burdens in the mouse systemic infection model, indicating that CFL1 might be a potential target for antifungal drug development.	Iron	85-89	cofilin 1, non-muscle	Mus musculus	22-26
24673255-3	2014	While low doses of (56)Fe radiation do not induce cell death of mature neurons, they affect synaptic plasticity in the CA1 region, the principal neuronal output of the hippocampal formation involved in memory formation.	Iron	23-25	carbonic anhydrase 1	Mus musculus	119-122
24663218-11	2014	KatA has a 5-coordinate high spin ferric heme that binds NO without prior reduction of the heme iron (Kd ~6 muM).	Iron	96-100	catalase	Pseudomonas aeruginosa PAO1	0-4
24711810-7	2014	In addition, FROs appear to play important roles in subcellular compartmentalization of iron as FRO7 is known to contribute to delivery of iron to chloroplasts while mitochondrial family members FRO3 and FRO8 are hypothesized to influence mitochondrial metal ion homeostasis.	Iron	88-92	ferric reduction oxidase 3	Arabidopsis thaliana	195-199
24641804-0	2014	Silencing of hepcidin enforces the apoptosis in iron-induced human cardiomyocytes.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	13-21
24641804-2	2014	Hepcidin is a well-known regulator of iron homeostasis.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	0-8
24641804-10	2014	Hepcidin levels increased in human cardiomyocytes pretreated with ferrous iron and returned to non-iron treated levels following siRNA2 transfection.	Iron	66-78	hepcidin antimicrobial peptide	Homo sapiens	0-8
24641804-10	2014	Hepcidin levels increased in human cardiomyocytes pretreated with ferrous iron and returned to non-iron treated levels following siRNA2 transfection.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	0-8
24641804-11	2014	In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged.	Iron	3-7	caspase 9	Homo sapiens	209-218
24641804-12	2014	CONCLUSIONS: Our findings suggest that hepcidin can rescue human cardiomyocytes from iron-induced apoptosis through the regulation of GATA-4/Bcl-2 and the extrinsic apoptotic pathway.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	39-47
24653703-4	2014	Inadequate hepcidin expression signals for excessive iron absorption from the diet and iron deposition in tissues causing multiple organ damage and failure.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	11-19
24653703-5	2014	This review focuses on the molecular actions of the HFE/Hfe and hepcidin in maintaining systemic iron homeostasis and approaches undertaken so far to combat iron overload in HFE/Hfe-HH.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	64-72
24304836-2	2014	Iron export from enterocytes or macrophages to blood plasma is thought to be mediated by ferroportin under the control of hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	122-130
24304836-9	2014	Hepcidin treatment of oocytes inhibited efflux of (55)Fe, (65)Zn, and (57)Co.	Iron	54-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
24325979-10	2014	CONCLUSION: Like controls, serum iron in XLH is inversely related to C-terminal FGF23 but not intact FGF23.	Iron	33-37	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	41-44
24325979-12	2014	The relationships of iron to FGF23 in XLH suggest that altered regulation of FGF23 cleaving may contribute to maintaining hypophosphatemia around an abnormal set-point.	Iron	21-25	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	38-41
23676854-1	2014	Hepcidin is a low-molecular-weight hepatic peptide that regulates iron homeostasis, and acts by causing the degradation of its receptor, the cellular iron exporter ferroportin.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
23676854-1	2014	Hepcidin is a low-molecular-weight hepatic peptide that regulates iron homeostasis, and acts by causing the degradation of its receptor, the cellular iron exporter ferroportin.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	0-8
23676854-2	2014	On the basis of the major role of the hepcidin-ferroportin axis in iron regulation, recently several studies have discussed its expression and influence on the development and prognosis of cancer.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	38-46
24420575-5	2014	The transcript levels of NtIRT1 and NtZIP1 were higher in transgenic plants, indicating an induction of the Fe and Zn deficiency status due to AtHMA4 expression.	Iron	108-110	probable zinc transporter 10	Nicotiana tabacum	25-31
24424393-4	2014	Hepcidin, the key regulator of iron homeostasis, is also an acute-phase reactant, which has a critical role in inflammation and contributes to host defense by interfering with microorganism"s access to iron.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
24424393-4	2014	Hepcidin, the key regulator of iron homeostasis, is also an acute-phase reactant, which has a critical role in inflammation and contributes to host defense by interfering with microorganism"s access to iron.	Iron	202-206	hepcidin antimicrobial peptide	Homo sapiens	0-8
24503898-4	2014	Further molecular characterization of this strain phenotype revealed that the lack of Pif1 leads to increased iron accumulation, redistribution of the aconitase protein to mitochondria, and also a loss of aconitase activity, despite normal Aco1 protein levels being present, probably due to the epistasis in protecting mtDNA between PIF1 and ACO1.	Iron	110-114	DNA helicase PIF1	Saccharomyces cerevisiae S288C	86-90
24505389-10	2014	Bacterial two-hybrid screens with human lung cDNA library as target were utilized to identify interaction partners of PpiA from host repertoire, and a number of substrates with functional representation in iron storage, signal transduction and immune responses were detected.	Iron	206-210	peptidylprolyl isomerase A	Homo sapiens	118-122
24334869-9	2014	CONCLUSIONS: Our results suggest that the body iron distribution as determined by hepcidin affects the development of atherosclerosis in women.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	82-90
24055163-0	2014	TFR2-related hereditary hemochromatosis as a frequent cause of primary iron overload in patients from Central-Southern Italy.	Iron	71-75	transferrin receptor 2	Homo sapiens	0-4
23720394-5	2014	RESULTS: Both phantom and in vivo human data confirmed that transverse relaxation components associated with the dispersed and aggregated iron could be separated using the two-parameter (RR2 , A) method.	Iron	138-142	ribonucleotide reductase regulatory subunit M2	Homo sapiens	187-190
24035247-7	2014	The magnitude of the positive associations of isocitrate dehydrogenase and myoglobin with iron was larger than for zinc, but they strongly indicated the association of these aerobic makers with both minerals.	Iron	90-94	myoglobin	Homo sapiens	75-84
24184387-0	2014	Hypoxia inducible factor-1alpha mediates iron uptake which induces inflammatory response in amoeboid microglial cells in developing periventricular white matter through MAP kinase pathway.	Iron	41-45	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-31
24184387-2	2014	As hypoxia has a role in altering the expression of proteins involved in iron regulation, this study was aimed at examining the interaction between hypoxia inducible factor (HIF)-1alpha and proteins involved in iron transport in microglial cells, and evaluating the mechanistic action of deferoxamine and KC7F2 (an inhibitor of HIF-1alpha) in iron mediated hypoxic injury.	Iron	211-215	hypoxia inducible factor 1, alpha subunit	Mus musculus	148-185
24184387-2	2014	As hypoxia has a role in altering the expression of proteins involved in iron regulation, this study was aimed at examining the interaction between hypoxia inducible factor (HIF)-1alpha and proteins involved in iron transport in microglial cells, and evaluating the mechanistic action of deferoxamine and KC7F2 (an inhibitor of HIF-1alpha) in iron mediated hypoxic injury.	Iron	211-215	hypoxia inducible factor 1, alpha subunit	Mus musculus	148-185
24465846-0	2014	Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.	Iron	125-129	arachidonate 15-lipoxygenase	Rattus norvegicus	66-72
24465846-8	2014	In iron-overloaded pancreas, the most upregulated transcripts were Reg1a, Reg3a, and Reg3b belonging to the regenerating islet-derived gene (Reg) family.	Iron	3-7	regenerating islet-derived 3 alpha	Rattus norvegicus	74-79
24465846-10	2014	Subsequent qRT-PCR validation indicated that Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas.	Iron	87-91	arachidonate 15-lipoxygenase	Rattus norvegicus	45-51
24465846-10	2014	Subsequent qRT-PCR validation indicated that Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas.	Iron	110-114	arachidonate 15-lipoxygenase	Rattus norvegicus	45-51
24465846-10	2014	Subsequent qRT-PCR validation indicated that Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas.	Iron	110-114	arachidonate 15-lipoxygenase	Rattus norvegicus	45-51
24394537-0	2014	Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2alpha.	Iron	0-4	endothelial PAS domain protein 1	Homo sapiens	95-104
24394537-8	2014	Thus, iron transport across the basal border via ferroportin is influenced by the intracellular status of ascorbate and IRP2 and HIF2alpha are involved.	Iron	6-10	endothelial PAS domain protein 1	Homo sapiens	129-138
24427162-8	2014	We show here that UBC13A/B and RGLG1/2 are involved in DNA damage repair and hypothesize that UBC13 protein becomes limited under iron-deficient conditions to prioritize DNA metabolism.	Iron	130-134	ubiquitin-conjugating enzyme 35	Arabidopsis thaliana	18-26
24583383-9	2014	The content of iron was significantly higher in liver of rats fed with PBF WM with sourdough bread in comparison to the groups fed with conventional WM and conventional WM with sourdough breads.	Iron	15-19	PTTG1 interacting protein	Rattus norvegicus	71-74
25648024-2	2014	Hepcidin is an antimicrobial and iron regulatory peptide produced by the liver in response to inflammation and elevated systemic iron.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
24275768-1	2014	PURPOSE OF REVIEW: Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide.	Iron	187-191	heme oxygenase 1	Homo sapiens	70-86
24275768-1	2014	PURPOSE OF REVIEW: Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide.	Iron	187-191	heme oxygenase 1	Homo sapiens	88-92
24293278-2	2014	Hepcidin expression is up-regulated by iron loading in vivo, but the mechanism underlying this process is not completely understood.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
24293278-3	2014	In the present study, we investigated the mechanism, following the hypothesis that hepcidin production in response to iron loading is regulated by extra-hepatic iron sensors.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	83-91
24293278-3	2014	In the present study, we investigated the mechanism, following the hypothesis that hepcidin production in response to iron loading is regulated by extra-hepatic iron sensors.	Iron	161-165	hepcidin antimicrobial peptide	Homo sapiens	83-91
24293278-9	2014	Our results suggest the existence of humoral factors capable of inducing hepcidin production that are secreted by extra-hepatic cells, such as reticuloendothelial monocytes, in response to iron.	Iron	189-193	hepcidin antimicrobial peptide	Homo sapiens	73-81
23860963-2	2014	Increased hepcidin, which downregulates the iron exporter ferroportin, has been incriminated.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	10-18
24731632-2	2014	Lactoferrin (LF), a siderophilic protein with 2 iron-binding sites, has been demonstrated to possess a multitude of biological functions, including antiinflammation, anticancer, and antimicrobial effects, as well as immunomodulatory-enhancing functions.	Iron	48-52	lactotransferrin	Rattus norvegicus	0-11
24731632-2	2014	Lactoferrin (LF), a siderophilic protein with 2 iron-binding sites, has been demonstrated to possess a multitude of biological functions, including antiinflammation, anticancer, and antimicrobial effects, as well as immunomodulatory-enhancing functions.	Iron	48-52	lactotransferrin	Rattus norvegicus	13-15
25762501-7	2014	We also show that ER stress combined with inflammation synergistically upregulated the expression of the iron carrier protein NGAL and the stress-inducible heme degrading enzyme heme oxygenase-1 (HO-1) leading to iron liberation.	Iron	213-217	heme oxygenase 1	Homo sapiens	178-194
24482599-8	2014	Gene expression of the exogenous ferritin gene in grain correlates with protein accumulation and iron concentration.	Iron	97-101	ferritin-1, chloroplastic	Glycine max	33-41
25016784-4	2014	The paper presents the current knowledge concerning the involvement of iron in the development of anemia in chronic kidney disease, with particular reference to the role of hepcidin in systemic iron circulation.	Iron	194-198	hepcidin antimicrobial peptide	Homo sapiens	173-181
25276251-0	2014	The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract.	Iron	61-65	solute carrier family 11 member 2	Homo sapiens	45-49
25276251-4	2014	Two transporters: Hem Carrier Protein 1 (HCP1) and Divalent Metal Transporter 1 (DMT1) appear to mediate the entry of most if not all dietary iron into these mucosal cells.	Iron	142-146	solute carrier family 46 member 1	Homo sapiens	18-39
25276251-4	2014	Two transporters: Hem Carrier Protein 1 (HCP1) and Divalent Metal Transporter 1 (DMT1) appear to mediate the entry of most if not all dietary iron into these mucosal cells.	Iron	142-146	solute carrier family 46 member 1	Homo sapiens	41-45
25276251-4	2014	Two transporters: Hem Carrier Protein 1 (HCP1) and Divalent Metal Transporter 1 (DMT1) appear to mediate the entry of most if not all dietary iron into these mucosal cells.	Iron	142-146	solute carrier family 11 member 2	Homo sapiens	51-79
25276251-4	2014	Two transporters: Hem Carrier Protein 1 (HCP1) and Divalent Metal Transporter 1 (DMT1) appear to mediate the entry of most if not all dietary iron into these mucosal cells.	Iron	142-146	solute carrier family 11 member 2	Homo sapiens	81-85
25276251-7	2014	Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
25276251-7	2014	Hepcidin, a 25-amino acid polypeptide, which is synthesised primarily in hepatocytes, reduces the iron absorption from the intestine by binding to the only known cellular iron exporter, ferroportin, causing it to be degraded.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	0-8
25276251-8	2014	Therefore, hepcidin is now considered to be the most important factor controlling iron absorption.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	11-19
23743883-3	2014	Hepcidin is a key regulator of iron homeostasis: downregulation in the presence of iron deficiency allows enteral iron resorption, while upregulation in case of chronic inflammation blocks it.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
23743883-3	2014	Hepcidin is a key regulator of iron homeostasis: downregulation in the presence of iron deficiency allows enteral iron resorption, while upregulation in case of chronic inflammation blocks it.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	0-8
25489488-5	2014	Concerning gene expression of iron regulatory proteins, old rats presented significantly higher mRNA levels of hepcidin (Hamp), transferrin (TF), transferrin receptor 2 (TfR2) and hemojuvelin (HJV); divalent metal transporter 1 (DMT1) mRNA levels were significantly higher in duodenal tissue; EPO gene expression was significantly higher in liver and lower in kidney, and the expression of the EPOR was significantly higher in both liver and kidney.	Iron	30-34	hemojuvelin BMP co-receptor	Rattus norvegicus	193-196
24358164-6	2013	We applied UV-VIS and EPR monitored redox-titrations to determine the redox potentials of wild type mAOX3 and mAOX3 variants containing the iron-sulfur centers of mAOX1.	Iron	140-144	aldehyde oxidase 3	Mus musculus	110-115
23879888-1	2013	The effects of lactoferrin (LF), an iron binding protein, on myelopoiesis have been studied extensively in vitro and in vivo in human and murine models over the past three decades.	Iron	36-40	lactotransferrin	Mus musculus	15-26
24282296-0	2013	Intestinal HIF2alpha promotes tissue-iron accumulation in disorders of iron overload with anemia.	Iron	37-41	endothelial PAS domain protein 1	Mus musculus	11-20
24282296-0	2013	Intestinal HIF2alpha promotes tissue-iron accumulation in disorders of iron overload with anemia.	Iron	71-75	endothelial PAS domain protein 1	Mus musculus	11-20
24282296-6	2013	We definitively demonstrate, using genetic mouse models, that intestinal hypoxia-inducible factor-2alpha (HIF2alpha) and divalent metal transporter-1 (DMT1) are activated early in the pathogenesis of beta-thalassemia and are essential for excess iron accumulation in mouse models of beta-thalassemia.	Iron	246-250	endothelial PAS domain protein 1	Mus musculus	73-104
24282296-6	2013	We definitively demonstrate, using genetic mouse models, that intestinal hypoxia-inducible factor-2alpha (HIF2alpha) and divalent metal transporter-1 (DMT1) are activated early in the pathogenesis of beta-thalassemia and are essential for excess iron accumulation in mouse models of beta-thalassemia.	Iron	246-250	endothelial PAS domain protein 1	Mus musculus	106-115
24282296-7	2013	Moreover, thalassemic mice with established iron overload had significant improvement in tissue-iron levels and anemia following disruption of intestinal HIF2alpha.	Iron	44-48	endothelial PAS domain protein 1	Mus musculus	154-163
24282296-9	2013	Mechanistic studies in a hemolytic anemia mouse model demonstrated that loss of intestinal HIF2alpha/DMT1 signaling led to decreased tissue-iron accumulation in the liver without worsening the anemia.	Iron	140-144	endothelial PAS domain protein 1	Mus musculus	91-100
24282296-10	2013	These data demonstrate that dysregulation of intestinal hypoxia and HIF2alpha signaling is critical for progressive iron overload in beta-thalassemia and may be a novel therapeutic target in several anemic iron-overload disorders.	Iron	116-120	endothelial PAS domain protein 1	Mus musculus	68-77
24339866-7	2013	RESULTS AND CONCLUSION: Hepcidin was a poor predictor of bone marrow iron deficiency (sensitivity 66.7%; specificity 48.5%), and of iron incorporation (sensitivity 54.2%; specificity 61.8%), and therefore would have limitations as a point of care test in this category of children.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	24-32
23842708-0	2013	Serum hepcidin measured with an improved ELISA correlates with parameters of iron metabolism in patients with myelodysplastic syndrome.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	6-14
23842708-3	2013	Hepcidin, a pivotal regulator of iron homeostasis, controls iron uptake in the duodenum as well as iron release from macrophages and is potentially involved in iron distribution to different organs.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
23842708-3	2013	Hepcidin, a pivotal regulator of iron homeostasis, controls iron uptake in the duodenum as well as iron release from macrophages and is potentially involved in iron distribution to different organs.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
23842708-3	2013	Hepcidin, a pivotal regulator of iron homeostasis, controls iron uptake in the duodenum as well as iron release from macrophages and is potentially involved in iron distribution to different organs.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
23842708-3	2013	Hepcidin, a pivotal regulator of iron homeostasis, controls iron uptake in the duodenum as well as iron release from macrophages and is potentially involved in iron distribution to different organs.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
23842708-18	2013	Measurement of serum hepcidin with an improved ELISA yield results that correlate with other parameters of iron metabolism as well as survival and transfusion needs.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	21-29
24179092-1	2013	Hepcidin is an antimicrobial peptide hormone that plays a central role in the metabolism of iron and its expression in the liver can be induced through two major pathways: the inflammatory pathway, mainly via IL-6; and the iron-sensing pathway, mediated by BMP-6.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	0-8
24179092-1	2013	Hepcidin is an antimicrobial peptide hormone that plays a central role in the metabolism of iron and its expression in the liver can be induced through two major pathways: the inflammatory pathway, mainly via IL-6; and the iron-sensing pathway, mediated by BMP-6.	Iron	223-227	hepcidin antimicrobial peptide	Homo sapiens	0-8
23742704-4	2013	We measured serum hepcidin and ferritin concentrations in a case-control study of 1259 Han Chinese participants to evaluate the possible associations of serum hepcidin concentrations with Fe metabolism parameters and risks of T2D.	Iron	188-190	hepcidin antimicrobial peptide	Homo sapiens	159-167
23796160-2	2013	Hepcidin is the key hormone that negatively regulates iron homeostasis.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
23796160-3	2013	We hypothesized that individuals with insulin resistance have inadequate hepcidin levels for their iron load.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	73-81
23796160-12	2013	Reduced hepcidin concentrations may cause increased body iron stores in insulin-resistant states.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	8-16
23871052-3	2013	The surface tension of Lf tends to decrease with decrease in iron content.	Iron	61-65	lactotransferrin	Bos taurus	23-25
23871052-5	2013	The Differential Scanning Calorimeter (DSC) analysis showed that the apo- and holo-Lf in aqueous solution displayed thermal denaturation temperatures of 71+-0.2 and 91+-0.5  C, respectively, suggesting that the iron saturation of Lf tends to increase its thermal stability.	Iron	211-215	lactotransferrin	Bos taurus	83-85
23871052-5	2013	The Differential Scanning Calorimeter (DSC) analysis showed that the apo- and holo-Lf in aqueous solution displayed thermal denaturation temperatures of 71+-0.2 and 91+-0.5  C, respectively, suggesting that the iron saturation of Lf tends to increase its thermal stability.	Iron	211-215	lactotransferrin	Bos taurus	230-232
23954231-8	2013	In this paper a Petri net based model of the hemojuvelin-hepcidin axis involved in the maintenance of the human body iron homeostasis is presented.	Iron	117-121	hemojuvelin BMP co-receptor	Homo sapiens	45-56
23954231-8	2013	In this paper a Petri net based model of the hemojuvelin-hepcidin axis involved in the maintenance of the human body iron homeostasis is presented.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	57-65
24154625-2	2013	Hx is the plasma protein with the highest binding affinity to heme and controls heme-iron availability in tissues and also in T lymphocytes, where it modulates their responsiveness to IFN-gamma.	Iron	85-89	hemopexin	Mus musculus	0-2
23749468-11	2013	The differences in iron metabolism between the two widely used fibrosis models likely reflect the differential regulation of hepcidin expression in human liver disease.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	125-133
24121729-10	2013	Furthermore, the liver-iron lowering effect of the N374S Mon1a mutation is observed only in mice that display a nonsense mutation in the Ceruloplasmin (Cp) gene.	Iron	23-27	ceruloplasmin	Mus musculus	137-150
24117875-3	2013	To develop an effective S. aureus candidate vaccine, overlapping PCR was used to add the truncated immunodominant antigen iron-regulated surface determinant B (IsdB)(N126-P361) (tIsdB) to the N-terminal of intact antigen target of RNAIII activating protein (TRAP) and thus construct a tIsdB-TRAP chimera.	Iron	122-126	tudor domain containing 7	Mus musculus	258-262
24117875-3	2013	To develop an effective S. aureus candidate vaccine, overlapping PCR was used to add the truncated immunodominant antigen iron-regulated surface determinant B (IsdB)(N126-P361) (tIsdB) to the N-terminal of intact antigen target of RNAIII activating protein (TRAP) and thus construct a tIsdB-TRAP chimera.	Iron	122-126	tudor domain containing 7	Mus musculus	291-295
23147161-2	2013	Hepcidin-25 is a key regulator of iron homeostasis, which downregulates the cellular iron exporter ferroportin.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
23147161-2	2013	Hepcidin-25 is a key regulator of iron homeostasis, which downregulates the cellular iron exporter ferroportin.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	0-8
24157792-1	2013	Hepcidin is a peptide hormone that is secreted by the liver and that functions as the central regulator of systemic iron metabolism in mammals.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	0-8
24157792-3	2013	There is considerable interest in understanding the mechanisms that influence hepcidin expression because dysregulation of hepcidin production is associated with a number of disease states and can lead to iron overload or iron-restricted anemia.	Iron	205-209	hepcidin antimicrobial peptide	Homo sapiens	123-131
24157792-3	2013	There is considerable interest in understanding the mechanisms that influence hepcidin expression because dysregulation of hepcidin production is associated with a number of disease states and can lead to iron overload or iron-restricted anemia.	Iron	222-226	hepcidin antimicrobial peptide	Homo sapiens	123-131
24218322-5	2013	Ceruloplasmin, a ferroxidase enzyme important in iron homeostasis, was undetectable and associated with low serum iron, low serum copper, and 10-fold increase in serum ferritin.	Iron	49-53	ceruloplasmin	Homo sapiens	0-13
24218322-5	2013	Ceruloplasmin, a ferroxidase enzyme important in iron homeostasis, was undetectable and associated with low serum iron, low serum copper, and 10-fold increase in serum ferritin.	Iron	114-118	ceruloplasmin	Homo sapiens	0-13
24036496-7	2013	Moreover, in iron-loaded M2 macrophages, LXR activation induces nuclear factor erythroid 2-like 2 expression, thereby increasing ferroportin expression, which, together with a decrease of hepcidin mRNA levels, promotes iron export.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	188-196
24188143-1	2013	BACKGROUND: Hepcidin, a peptide that is released into the blood in response to inflammation, prevents cellular iron export and results in declines in iron status.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	12-20
24188143-1	2013	BACKGROUND: Hepcidin, a peptide that is released into the blood in response to inflammation, prevents cellular iron export and results in declines in iron status.	Iron	150-154	hepcidin antimicrobial peptide	Homo sapiens	12-20
24188143-10	2013	Future studies should strive to identify the role of hepcidin in the adaptive response to exercise, as well as countermeasures for the prevention of chronic or repeated elevations in serum hepcidin due to exercise or sustained occupational tasks which may result in longer term decrements in iron status.	Iron	292-296	hepcidin antimicrobial peptide	Homo sapiens	189-197
23798368-3	2013	Hepcidin decreases iron export into the plasma by binding to and inducing the degradation of ferroportin, an iron channel located on macrophages and the basolateral surface of enterocytes.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	0-8
23798368-3	2013	Hepcidin decreases iron export into the plasma by binding to and inducing the degradation of ferroportin, an iron channel located on macrophages and the basolateral surface of enterocytes.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	0-8
24157963-2	2013	This review focuses on the past decade of discovery in the field of iron homeostasis, which has identified "new friends" or key modifiers of the critical systemic iron regulator, hepcidin antimicrobial peptide.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	179-187
24157963-2	2013	This review focuses on the past decade of discovery in the field of iron homeostasis, which has identified "new friends" or key modifiers of the critical systemic iron regulator, hepcidin antimicrobial peptide.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	179-187
23943044-7	2013	This pre-selective step of parasitic eradication will be used further for a test of the Malaria Box with a potential in iron chelating capacity to inhibit deoxyhypusine hydroxylase (DOHH) from P. falciparum and vivax.	Iron	120-124	deoxyhypusine hydroxylase	Homo sapiens	155-180
23943044-7	2013	This pre-selective step of parasitic eradication will be used further for a test of the Malaria Box with a potential in iron chelating capacity to inhibit deoxyhypusine hydroxylase (DOHH) from P. falciparum and vivax.	Iron	120-124	deoxyhypusine hydroxylase	Homo sapiens	182-186
23943044-8	2013	DOHH, a metalloprotein which consists of ferrous iron and catalyzes the second step of the posttranslational modification at a specific lysine in eukaryotic initiation factor 5A (EIF-5A) to hypusine.	Iron	49-53	deoxyhypusine hydroxylase	Homo sapiens	0-4
23943044-8	2013	DOHH, a metalloprotein which consists of ferrous iron and catalyzes the second step of the posttranslational modification at a specific lysine in eukaryotic initiation factor 5A (EIF-5A) to hypusine.	Iron	49-53	eukaryotic translation initiation factor 5A	Homo sapiens	146-177
23943044-8	2013	DOHH, a metalloprotein which consists of ferrous iron and catalyzes the second step of the posttranslational modification at a specific lysine in eukaryotic initiation factor 5A (EIF-5A) to hypusine.	Iron	49-53	eukaryotic translation initiation factor 5A	Homo sapiens	179-185
23760782-1	2013	Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of systemic iron homeostasis.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	10-18
23760782-2	2013	Hepcidin integrates signals from diverse physiological inputs, forming a key connection between iron trafficking and response to infection.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	0-8
23760782-7	2013	Hepcidin increased significantly in noninfected children with IDA after 3 months of oral iron therapy (P &lt; 0.01).	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	0-8
23760782-8	2013	On the other hand, H. pylori-infected children showed nonsignificant change in hepcidin level after oral iron therapy (P &gt; 0.05).	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	79-87
23760782-9	2013	Although hepcidin showed significant positive correlations with serum ferritin, hemoglobin (Hb), iron, and transferrin saturation in noninfected children with IDA (P &lt; 0.01), it showed significant negative correlations with serum ferritin, Hb, iron, and transferrin saturation in H. pylori-infected children with IDA (P &lt; 0.05).	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	9-17
23760782-9	2013	Although hepcidin showed significant positive correlations with serum ferritin, hemoglobin (Hb), iron, and transferrin saturation in noninfected children with IDA (P &lt; 0.01), it showed significant negative correlations with serum ferritin, Hb, iron, and transferrin saturation in H. pylori-infected children with IDA (P &lt; 0.05).	Iron	247-251	hepcidin antimicrobial peptide	Homo sapiens	9-17
24180234-8	2013	CONCLUSIONS: AtPAP2 overexpression resulted in a widespread reprogramming of the transcriptome in the transgenic plants, which is characterized by changes in the carbon, nitrogen, potassium, and iron metabolism.	Iron	195-199	Purple acid phosphatases superfamily protein	Arabidopsis thaliana	13-19
24186312-1	2013	Hepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	0-8
24186312-3	2013	Hepcidin insufficiency results in iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemias in inflammatory diseases, infections, some cancers and chronic kidney disease.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
24186312-3	2013	Hepcidin insufficiency results in iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemias in inflammatory diseases, infections, some cancers and chronic kidney disease.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
24186312-3	2013	Hepcidin insufficiency results in iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemias in inflammatory diseases, infections, some cancers and chronic kidney disease.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
23803460-5	2013	Hepcidin, a protein mainly produced by hepatocytes, is thought to be a key regulator in iron release from reticuloendothelial cells (RECs), and its expression is related to ACD.	Iron	88-92	hepcidin antimicrobial peptide	Canis lupus familiaris	0-8
23803460-6	2013	We hypothesized that in the case of long-term ACD, iron deposition in RECs increases through hepcidin, causing a diachronic increase in serum ferritin levels.	Iron	51-55	hepcidin antimicrobial peptide	Canis lupus familiaris	93-101
24179613-2	2013	HO-1, a stress-responsive enzyme that catabolizes heme into carbon monoxide (CO), biliverdin and iron, has previously been shown to protect grafts from ischemia/reperfusion and rejection.	Iron	97-101	heme oxygenase 1	Homo sapiens	0-4
23945155-2	2013	Iron metabolism is controlled by hepcidin, a 25-amino-acid peptide.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	33-41
23945155-3	2013	Hepcidin is induced by inflammation and causes iron to be sequestered within cells of the reticuloendothelial system, suppressing erythropoiesis and blunting the activity of erythropoiesis stimulating agents (ESAs).	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
23945155-5	2013	The aim of the current work was to generate fully human anti-hepcidin antibodies (Abs) as a potential human therapeutic for the treatment of AI and other iron maldistribution disorders.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	61-69
23945155-7	2013	Using human hepcidin knock-in mice, the mechanism of action of the Abs was shown to be due to an increase in available serum iron leading to enhanced red cell hemoglobinization.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	12-20
23990467-5	2013	In this report, we provide evidence that Steap4, a member of the six-transmembrane epithelial antigen of prostate (Steap) family proteins, is an endosomal ferrireductase with a critical role in cellular iron utilization in osteoclasts.	Iron	203-207	STEAP family member 1	Homo sapiens	41-46
23946486-0	2013	Binding of the chaperone Jac1 protein and cysteine desulfurase Nfs1 to the iron-sulfur cluster scaffold Isu protein is mutually exclusive.	Iron	75-79	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	25-29
23956390-6	2013	Slt2 exerts this effect independently of the intracellular levels of reactive oxygen species (ROS) and of iron homeostasis.	Iron	106-110	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	0-4
23582772-4	2013	The discovery of hepcidin has allowed a better clarification of iron metabolism regulation.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	17-25
23580449-2	2013	Recent studies have provided evidence that the iron-regulating hormone hepcidin is transiently increased with acute exercise and suggest that this may contribute to iron deficiency anemia in athletes.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	71-79
23580449-2	2013	Recent studies have provided evidence that the iron-regulating hormone hepcidin is transiently increased with acute exercise and suggest that this may contribute to iron deficiency anemia in athletes.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	71-79
23820728-8	2013	Importantly, deletion of a bifunctional alcohol and acetaldehyde dehydrogenase (ADH1), which is induced under low iron based on the proteomic data, attenuates the remodeling of the photosynthetic machinery in response to iron deficiency, and at the same time stimulates expression of stress-related proteins such as NDA2, LHCSR3, and PGRL1.	Iron	114-118	uncharacterized protein	Chlamydomonas reinhardtii	80-84
23820728-8	2013	Importantly, deletion of a bifunctional alcohol and acetaldehyde dehydrogenase (ADH1), which is induced under low iron based on the proteomic data, attenuates the remodeling of the photosynthetic machinery in response to iron deficiency, and at the same time stimulates expression of stress-related proteins such as NDA2, LHCSR3, and PGRL1.	Iron	114-118	uncharacterized protein	Chlamydomonas reinhardtii	322-328
24127501-1	2013	Hepcidin inhibits the iron export from duodenal cells and liver cells into the plasma and therefore plays a key role in controlling iron homeostasis.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
24127501-1	2013	Hepcidin inhibits the iron export from duodenal cells and liver cells into the plasma and therefore plays a key role in controlling iron homeostasis.	Iron	132-136	hepcidin antimicrobial peptide	Homo sapiens	0-8
23841713-2	2013	The chronic low-grade inflammation that characterizes obesity enhances hepcidin production, the principal regulator of iron availability.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	71-79
24137020-1	2013	The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	17-25
23935105-5	2013	FANCJ belongs to a conserved iron-sulfur (Fe S) cluster family of helicases important for genomic stability including XPD (nucleotide excision repair), DDX11 (sister chromatid cohesion), and RTEL (telomere metabolism), genetically linked to xeroderma pigmentosum/Cockayne syndrome, Warsaw breakage syndrome, and dyskeratosis congenita, respectively.	Iron	29-33	BRCA1 interacting helicase 1	Homo sapiens	0-5
23935105-5	2013	FANCJ belongs to a conserved iron-sulfur (Fe S) cluster family of helicases important for genomic stability including XPD (nucleotide excision repair), DDX11 (sister chromatid cohesion), and RTEL (telomere metabolism), genetically linked to xeroderma pigmentosum/Cockayne syndrome, Warsaw breakage syndrome, and dyskeratosis congenita, respectively.	Iron	29-33	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	118-121
23249217-2	2013	CYB561s function as monodehydroascorbate reductase, regenerating ASC, and as Fe3+-reductases, providing reduced iron for TM transport.	Iron	112-116	cytochrome b561	Homo sapiens	0-6
23249217-5	2013	Physiological functions supported by CYB561s and CYBDOMs include stress defense, cell wall modifications, iron metabolism, tumor suppression, and various neurological processes, including memory retention.	Iron	106-110	cytochrome b561	Homo sapiens	37-43
24146699-2	2013	The relationship between hepcidin and iron homeostasis in cancerous pathology is incompletely known, although it has been studied during the last years.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	25-33
23959881-5	2013	Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy.	Iron	305-309	nuclear assembly factor 1 ribonucleoprotein	Homo sapiens	40-45
23867871-1	2013	BACKGROUND: Hepcidin, a peptide produced by hepatocytes, regulates body iron homeostasis.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	12-20
23867871-11	2013	CONCLUSIONS: In IBD, iron stores, inflammation, and iron requirement for erythropoiesis influence serum hepcidin-25.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	104-112
23867871-11	2013	CONCLUSIONS: In IBD, iron stores, inflammation, and iron requirement for erythropoiesis influence serum hepcidin-25.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	104-112
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	19-23	endothelial PAS domain protein 1	Mus musculus	86-95
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	120-124	endothelial PAS domain protein 1	Mus musculus	86-95
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	120-124	endothelial PAS domain protein 1	Mus musculus	86-95
23940258-6	2013	Increased iron incorporation into the FtH homopolymer leads to reduced cellular iron availability, diminished levels of cytosolic catalase, SOD1 protein levels, enhanced ROS production and higher levels of oxidized proteins.	Iron	80-84	ferritin heavy chain 1	Homo sapiens	38-41
23643854-9	2013	Serum hepcidin-25 concentrations were strongly correlated with ferritin and, to a lesser extent, with iron levels.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	6-14
23798678-6	2013	Nbp35 readily bound (55)Fe when fed to cells, whereas (55)Fe binding by free Cfd1 could not be detected.	Iron	58-60	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	77-81
23798678-7	2013	Rapid (55)Fe binding to and release from Nbp35 was impaired by Cfd1 deficiency.	Iron	10-12	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	41-46
23798678-8	2013	A Cfd1 mutation that caused a defect in heterocomplex stability supported iron binding to Nbp35 but impaired iron release.	Iron	74-78	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	2-6
23798678-8	2013	A Cfd1 mutation that caused a defect in heterocomplex stability supported iron binding to Nbp35 but impaired iron release.	Iron	74-78	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	90-95
23798678-8	2013	A Cfd1 mutation that caused a defect in heterocomplex stability supported iron binding to Nbp35 but impaired iron release.	Iron	109-113	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	2-6
23891004-0	2013	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	Iron	46-50	cytosolic iron-sulfur assembly component 2B	Homo sapiens	23-28
23891004-0	2013	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	Iron	46-50	cytosolic iron-sulfur assembly component 2B	Homo sapiens	29-35
23891004-0	2013	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	Iron	120-124	cytosolic iron-sulfur assembly component 2B	Homo sapiens	23-28
23891004-0	2013	Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.	Iron	120-124	cytosolic iron-sulfur assembly component 2B	Homo sapiens	29-35
23891004-6	2013	Surprisingly, a second layer of iron regulation involves the stabilization of IRP2 by CIA2A binding or upon depletion of CIA2B or MMS19, even though IRP2 lacks an Fe/S cluster.	Iron	32-36	cytosolic iron-sulfur assembly component 2B	Homo sapiens	121-126
23917168-6	2013	Here we focus on the regulatory role of the hepcidin/ferroportin circuitry as the major regulator of systemic iron homeostasis.	Iron	110-114	hepcidin antimicrobial peptide	Homo sapiens	44-52
23917168-7	2013	We discuss how regulatory cues (e.g., iron, inflammation, or hypoxia) affect the hepcidin response and how impairment of the hepcidin/ferroportin regulatory system causes disorders of iron metabolism.	Iron	184-188	hepcidin antimicrobial peptide	Homo sapiens	125-133
23803887-9	2013	Calculations of iron bioavailability in HH were made by extrapolating data on hepcidin concentrations and their association with iron bioavailability.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	78-86
23615401-8	2013	HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells.	Iron	49-53	heme oxygenase 1	Homo sapiens	0-4
23863711-6	2013	In vitro studies demonstrated that erythroid repression by inflammatory signaling is potently modulated by the erythroid iron restriction response in a kinase-dependent pathway involving induction of the erythroid-inhibitory transcription factor PU.1.	Iron	121-125	Spi-1 proto-oncogene	Homo sapiens	246-250
23633457-5	2013	In FH-deficient kidney cancer, levels of AMP-activated protein kinase (AMPK), a cellular energy sensor, are decreased resulting in diminished p53 levels, decreased expression of the iron importer, DMT1, leading to low cellular iron levels, and to enhanced fatty acid synthesis by diminishing phosphorylation of acetyl CoA carboxylase, a rate-limiting step for fatty acid synthesis.	Iron	182-186	doublesex and mab-3 related transcription factor 1	Homo sapiens	197-201
23356500-1	2013	OBJECTIVES: Hepcidin is considered a major regulator of iron metabolism.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	12-20
23700338-1	2013	Hepcidin, the pivotal regulator of iron metabolism, plays a critical role in multiple diseases including anemia of chronic disease and hemochromatosis.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	0-8
23345622-2	2013	Excess levels of the iron regulatory hormone hepcidin are thought to contribute to anemia in CKD patients by decreasing iron availability from the diet and from body stores.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	45-53
23345622-2	2013	Excess levels of the iron regulatory hormone hepcidin are thought to contribute to anemia in CKD patients by decreasing iron availability from the diet and from body stores.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	45-53
23953340-4	2013	Hepcidin being the central regulator of iron metabolism plays a key role in the pathophysiology of ACD.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
23953340-5	2013	Hepcidin binds to the iron export protein, ferroportin, present on macrophages, hepatocytes, and enterocytes, causing degradation of the latter.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
23953340-7	2013	Production of hepcidin is in turn regulated by iron stores, inflammation, and erythropoiesis via the BMP-SMAD and JAK-STAT signaling pathways.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	14-22
23826373-0	2013	Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake.	Iron	63-67	hemopexin	Mus musculus	23-32
23826373-3	2013	Hemopexin is an acute phase protein that limits iron access to microorganisms.	Iron	48-52	hemopexin	Mus musculus	0-9
23826373-5	2013	Considering its involvement in iron homeostasis, it was postulated that hemopexin may play a role in the physiological absorption of inorganic iron.	Iron	31-35	hemopexin	Mus musculus	72-81
23826373-5	2013	Considering its involvement in iron homeostasis, it was postulated that hemopexin may play a role in the physiological absorption of inorganic iron.	Iron	143-147	hemopexin	Mus musculus	72-81
23826373-6	2013	METHODS AND RESULTS: Hemopexin-null mice showed elevated iron deposits in enterocytes, associated with higher duodenal H-Ferritin levels and a significant increase in duodenal expression and activity of heme oxygenase.	Iron	57-61	hemopexin	Mus musculus	21-30
23826373-8	2013	The rate of iron absorption was assessed by measuring the amount of (57)Fe retained in tissues from hemopexin-null and wild-type animals after administration of an oral dose of (57)FeSO4 or of (57)Fe-labelled heme.	Iron	12-16	hemopexin	Mus musculus	100-109
23826373-9	2013	Higher iron retention in the duodenum of hemopexin-null mice was observed as compared with normal mice.	Iron	7-11	hemopexin	Mus musculus	41-50
23826373-11	2013	CONCLUSIONS: The increased iron level in hemopexin-null duodenum can be accounted for by an increased iron uptake by enterocytes and storage in ferritins.	Iron	27-31	hemopexin	Mus musculus	41-50
23826373-11	2013	CONCLUSIONS: The increased iron level in hemopexin-null duodenum can be accounted for by an increased iron uptake by enterocytes and storage in ferritins.	Iron	102-106	hemopexin	Mus musculus	41-50
23826373-12	2013	These data indicate that the lack of hemopexin under physiological conditions leads to an enhanced duodenal iron uptake thus providing new insights to our understanding of body iron homeostasis.	Iron	108-112	hemopexin	Mus musculus	37-46
23826373-12	2013	These data indicate that the lack of hemopexin under physiological conditions leads to an enhanced duodenal iron uptake thus providing new insights to our understanding of body iron homeostasis.	Iron	177-181	hemopexin	Mus musculus	37-46
23552742-1	2013	BACKGROUND: Hepcidin-25 is a peptide hormone involved in iron absorption and homeostasis and found at increased serum levels in conditions involving systemic inflammation, renal dysfunction, and increased adiposity.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	12-20
23665013-1	2013	Hepcidin, a hepatic hormone, regulates serum iron levels by controlling both intestinal iron absorption and iron release from macrophages.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
23665013-1	2013	Hepcidin, a hepatic hormone, regulates serum iron levels by controlling both intestinal iron absorption and iron release from macrophages.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	0-8
23665013-1	2013	Hepcidin, a hepatic hormone, regulates serum iron levels by controlling both intestinal iron absorption and iron release from macrophages.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	0-8
23776499-0	2013	Decreased serum hepcidin concentration correlates with brain iron deposition in patients with HBV-related cirrhosis.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	16-24
23776499-3	2013	Hepcidin, a liver-produced, 25-aminoacid peptide, is the major regulator of systemic iron metabolism.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	0-8
23776499-5	2013	Our study was aimed to explore the relationship between brain iron content in patients with HBV-related cirrhosis and serum hepcidin level.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	124-132
23776499-9	2013	Pearson correlation analysis was performed to investigate correlation between brain iron concentrations and serum hepcidin, or other iron parameters.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	114-122
23776499-13	2013	CONCLUSIONS: Decreased serum hepcidin level correlated with excessive iron accumulation in the basal ganglia in HBV-related cirrhotic patients.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	29-37
23776499-15	2013	Serum hepcidin may be a clinical biomarker for brain iron deposition in cirrhotic patients, which may have therapeutic potential.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	6-14
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	20-24	ATPase copper transporting alpha	Rattus norvegicus	155-160
23776592-2	2013	Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1).	Iron	215-219	ATPase copper transporting alpha	Rattus norvegicus	155-160
22900975-2	2013	Dissociation of ferriprotoporphyrin IX from the globin and release of iron atoms can also occur as oxidized Mb accumulates.	Iron	70-74	myoglobin	Homo sapiens	108-110
23662810-2	2013	Does the hormone of iron metabolism, hepcidin, exhibit "self-control"?	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	37-45
23662810-3	2013	Hepcidin is a small, disulfide-rich peptide synthesized by the liver, which plays a keystone role in regulating systemic iron metabolism in mammals.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	0-8
23662810-4	2013	Hepcidin acts by binding and triggering the lysosomal degradation of the cellular iron exporter ferroportin.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
23662810-12	2013	In conclusion, the discovery of a hepcidin auto-regulatory pathway, first, supports the emerging notion that hepcidin regulation is exquisitely fine-tuned through a process of combinatorial control; and secondly, suggests that hepcidin may play a hand in its own deregulation in diseases of iron metabolism that involve aberrant cytokine signalling (e.g. the anaemia of inflammation).	Iron	291-295	hepcidin antimicrobial peptide	Homo sapiens	34-42
23662810-12	2013	In conclusion, the discovery of a hepcidin auto-regulatory pathway, first, supports the emerging notion that hepcidin regulation is exquisitely fine-tuned through a process of combinatorial control; and secondly, suggests that hepcidin may play a hand in its own deregulation in diseases of iron metabolism that involve aberrant cytokine signalling (e.g. the anaemia of inflammation).	Iron	291-295	hepcidin antimicrobial peptide	Homo sapiens	109-117
23662810-12	2013	In conclusion, the discovery of a hepcidin auto-regulatory pathway, first, supports the emerging notion that hepcidin regulation is exquisitely fine-tuned through a process of combinatorial control; and secondly, suggests that hepcidin may play a hand in its own deregulation in diseases of iron metabolism that involve aberrant cytokine signalling (e.g. the anaemia of inflammation).	Iron	291-295	hepcidin antimicrobial peptide	Homo sapiens	109-117
23573868-1	2013	In myelodysplastic syndromes with ring sideroblasts (MDS-RS), the iron deposited in the mitochondria of RS is present in the form of mitochondrial ferritin (FTMT), but it is unknown whether FTMT overexpression is the cause or the result of mitochondrial iron deposition.	Iron	66-70	ferritin mitochondrial	Homo sapiens	133-155
23573868-1	2013	In myelodysplastic syndromes with ring sideroblasts (MDS-RS), the iron deposited in the mitochondria of RS is present in the form of mitochondrial ferritin (FTMT), but it is unknown whether FTMT overexpression is the cause or the result of mitochondrial iron deposition.	Iron	66-70	ferritin mitochondrial	Homo sapiens	157-161
23573868-1	2013	In myelodysplastic syndromes with ring sideroblasts (MDS-RS), the iron deposited in the mitochondria of RS is present in the form of mitochondrial ferritin (FTMT), but it is unknown whether FTMT overexpression is the cause or the result of mitochondrial iron deposition.	Iron	66-70	ferritin mitochondrial	Homo sapiens	190-194
23573868-1	2013	In myelodysplastic syndromes with ring sideroblasts (MDS-RS), the iron deposited in the mitochondria of RS is present in the form of mitochondrial ferritin (FTMT), but it is unknown whether FTMT overexpression is the cause or the result of mitochondrial iron deposition.	Iron	254-258	ferritin mitochondrial	Homo sapiens	133-155
23573868-7	2013	In conclusion, experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis.	Iron	76-80	ferritin mitochondrial	Homo sapiens	46-50
23390091-0	2013	Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	142-150
23454680-8	2013	These results support a new hypothesis of synergistic alpha-syn/iron cytotoxicity, whereby ferrous iron induces alpha-syn aggregation and neurotoxicity by inhibiting Nrf2/HO-1.	Iron	64-68	heme oxygenase 1	Homo sapiens	171-175
23454680-9	2013	Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD.	Iron	92-96	heme oxygenase 1	Homo sapiens	19-23
23454680-9	2013	Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD.	Iron	92-96	synuclein alpha	Homo sapiens	145-154
23454680-9	2013	Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD.	Iron	126-130	heme oxygenase 1	Homo sapiens	19-23
23454680-9	2013	Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD.	Iron	126-130	synuclein alpha	Homo sapiens	38-47
23722909-0	2013	Iron regulation by hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	19-27
23722909-1	2013	Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
23722909-2	2013	Physiologically, hepcidin is controlled by iron stores, inflammation, hypoxia, and erythropoiesis.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	17-25
23722909-3	2013	The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple proteins, including hemojuvelin, bone morphogenetic protein 6 (BMP6), hereditary hemochromatosis protein, transferrin receptor 2, matriptase-2, neogenin, BMP receptors, and transferrin.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	18-26
23312499-5	2013	Higher hepcidin levels were protective against iron overload in infants from the 380 mg Fe/kg condition.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	7-15
23556518-2	2013	Mutations in TfR2 can lead to a rare form of the iron overload disease, hereditary hemochromatosis.	Iron	49-53	transferrin receptor 2	Homo sapiens	13-17
23556518-3	2013	TfR2 is proposed to sense body iron levels and increase the level of expression of the iron regulatory hormone, hepcidin.	Iron	31-35	transferrin receptor 2	Homo sapiens	0-4
23556518-3	2013	TfR2 is proposed to sense body iron levels and increase the level of expression of the iron regulatory hormone, hepcidin.	Iron	87-91	transferrin receptor 2	Homo sapiens	0-4
23556518-3	2013	TfR2 is proposed to sense body iron levels and increase the level of expression of the iron regulatory hormone, hepcidin.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	112-120
23556518-11	2013	Thus, the putative iron-sensing function of TfR2 could not be achieved in the absence of N-linked oligosaccharides.	Iron	19-23	transferrin receptor 2	Homo sapiens	44-48
23675379-0	2013	Iron-biofortification in rice by the introduction of three barley genes participated in mugineic acid biosynthesis with soybean ferritin gene.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	128-136
23675379-3	2013	Previously, expression of the iron storage protein, ferritin, in rice using an endosperm-specific promoter resulted in a two-fold increase in iron concentration in the resultant transgenic seeds.	Iron	30-34	ferritin-1, chloroplastic	Glycine max	52-60
23675379-3	2013	Previously, expression of the iron storage protein, ferritin, in rice using an endosperm-specific promoter resulted in a two-fold increase in iron concentration in the resultant transgenic seeds.	Iron	142-146	ferritin-1, chloroplastic	Glycine max	52-60
23675379-12	2013	These results indicate that the concomitant introduction of the ferritin gene and mugineic acid biosynthetic genes effectively increased the seed iron level without causing iron sensitivity under iron-limited conditions.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	64-72
23675379-12	2013	These results indicate that the concomitant introduction of the ferritin gene and mugineic acid biosynthetic genes effectively increased the seed iron level without causing iron sensitivity under iron-limited conditions.	Iron	173-177	ferritin-1, chloroplastic	Glycine max	64-72
23675379-12	2013	These results indicate that the concomitant introduction of the ferritin gene and mugineic acid biosynthetic genes effectively increased the seed iron level without causing iron sensitivity under iron-limited conditions.	Iron	173-177	ferritin-1, chloroplastic	Glycine max	64-72
23667491-0	2013	Characterizing the crucial components of iron homeostasis in the maize mutants ys1 and ys3.	Iron	41-45	iron-phytosiderophore transporter yellow stripe 1	Zea mays	79-82
23667491-2	2013	Yellow stripe 1 (ys1) and ys3 are recessive mutants of maize (Zea mays L.) that show typical symptoms of Fe deficiency, i.e., interveinal chlorosis of the leaves.	Iron	105-107	iron-phytosiderophore transporter yellow stripe 1	Zea mays	17-20
23426198-1	2013	PURPOSE OF REVIEW: The circulating peptide hepcidin modulates systemic iron balance by limiting the absorption of dietary iron and the release of iron from macrophage stores.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	43-51
23426198-1	2013	PURPOSE OF REVIEW: The circulating peptide hepcidin modulates systemic iron balance by limiting the absorption of dietary iron and the release of iron from macrophage stores.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	43-51
23426198-1	2013	PURPOSE OF REVIEW: The circulating peptide hepcidin modulates systemic iron balance by limiting the absorption of dietary iron and the release of iron from macrophage stores.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	43-51
23426198-2	2013	Recent studies conducted in humans, animal models, and tissue culture systems have enhanced our understanding of the molecular mechanisms by which hepcidin levels are altered in response to iron stores, inflammation, and erythropoietic activity.	Iron	190-194	hepcidin antimicrobial peptide	Homo sapiens	147-155
23426198-9	2013	Improved understanding of the signaling pathways involved in hepcidin regulation may contribute to improved therapeutic outcomes for patients with genetic and acquired disorders that impact systemic iron balance.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	61-69
23567781-9	2013	CONCLUSIONS: The measurements of iron, whether in acute (dextran sodium sulfate) or chronic (T-cell transfer) models of colitis, were generally consistent with iron-deficient anemia, with large increases in erythropoietin indicative of tissue hypoxia.	Iron	33-37	erythropoietin	Mus musculus	207-221
23270517-1	2013	Lactoferrin (LF), which belongs to the iron-binding transferrin family, is an important regulator of the levels of free iron in the body fluids.	Iron	39-43	lactotransferrin	Mus musculus	0-11
23270517-1	2013	Lactoferrin (LF), which belongs to the iron-binding transferrin family, is an important regulator of the levels of free iron in the body fluids.	Iron	39-43	lactotransferrin	Mus musculus	13-15
23270517-1	2013	Lactoferrin (LF), which belongs to the iron-binding transferrin family, is an important regulator of the levels of free iron in the body fluids.	Iron	120-124	lactotransferrin	Mus musculus	0-11
23270517-1	2013	Lactoferrin (LF), which belongs to the iron-binding transferrin family, is an important regulator of the levels of free iron in the body fluids.	Iron	120-124	lactotransferrin	Mus musculus	13-15
23626815-3	2013	Using porewater and sediment profiles for sites in an oligotrophic coastal basin (Bothnian Sea), we provide evidence for the formation of Fe-bound P (possibly vivianite; Fe3(PO4)2( )8H2O) below the zone of AOM with sulfate.	Iron	138-140	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	91-94
23509347-4	2013	Consistent with a role for iron-dependent inhibition of protein tyrosine phosphatases, SLC11A1(+) lymphocytes were more prone to activation and retained tyrosine phosphorylation.	Iron	27-31	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	87-94
23380741-6	2013	While different profiles of pro- and anti-inflammatory cytokines were observed between the malaria syndromes, circulatory hepcidin levels remained associated with the levels of its regulatory cytokine interleukin-6 and of the anti-inflammatory cytokine inerleukin-10, irrespective of iron status, anemic status, and general acute-phase response.	Iron	284-288	hepcidin antimicrobial peptide	Homo sapiens	122-130
23593390-9	2013	Enriched-iron diet increased hematocrit values, serum iron, gamma-glutamyl transferase, iron concentrations and oxidative stress in the majority of tissues.	Iron	9-13	gamma-glutamyltransferase 1	Rattus norvegicus	60-86
23448585-2	2013	This study investigated the role of AA in conjunction with the presence of iron minerals over a wide pH range for the reduction of CCl(4) in aqueous systems.	Iron	75-79	C-C motif chemokine ligand 4	Homo sapiens	131-137
23448585-7	2013	Furthermore, the reduction rate of CCl(4) by AA at pH of 13 could be enhanced with the presence of iron minerals (Fe(3)O(4), Fe(2)O(3), FeOOH, and FeS2).	Iron	99-103	C-C motif chemokine ligand 4	Homo sapiens	35-41
23448585-8	2013	In the absence or presence of iron minerals, the fraction of CCl(4) transformed to CHCl(3) was less than 1, indicating simultaneous one- and two-electron transfer processes.	Iron	30-34	C-C motif chemokine ligand 4	Homo sapiens	61-67
23424051-1	2013	Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia.	Iron	20-24	ceruloplasmin	Mus musculus	0-13
23424051-1	2013	Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia.	Iron	20-24	ceruloplasmin	Mus musculus	32-43
23424051-3	2013	Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that was rescued by iron chelation.	Iron	136-140	ceruloplasmin	Mus musculus	65-78
23424051-4	2013	Additionally, peripheral infusion of ceruloplasmin attenuated neurodegeneration and nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model for PD.	Iron	91-95	ceruloplasmin	Mus musculus	37-50
23506870-4	2013	SLC11A2 is a key player in iron metabolism and is ubiquitously expressed, most notably in the proximal duodenum, immature erythroid cells, brain, placenta and kidney.	Iron	27-31	solute carrier family 11 member 2	Homo sapiens	0-7
23506870-5	2013	Intestinal iron absorption is mediated by SLC11A2 at the apical membrane of enterocytes, followed by basolateral exit via SLC40A1.	Iron	11-15	solute carrier family 11 member 2	Homo sapiens	42-49
23506870-5	2013	Intestinal iron absorption is mediated by SLC11A2 at the apical membrane of enterocytes, followed by basolateral exit via SLC40A1.	Iron	11-15	solute carrier family 40 member 1	Homo sapiens	122-129
23506870-7	2013	Both SLC11A1 and SLC11A2 play an important role in macrophage iron recycling.	Iron	62-66	solute carrier family 11 member 2	Homo sapiens	17-24
23506870-8	2013	SLC11A2 also transports iron into the cytosol across the membrane of endocytotic vesicles of the transferrin receptor-cycle.	Iron	24-28	solute carrier family 11 member 2	Homo sapiens	0-7
23506870-9	2013	SLC40A1 is the sole member of the SLC40 family and is involved in the only cellular iron efflux mechanism described.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	0-7
23506870-10	2013	SLC40A1 is highly expressed in several tissues and cells that play a critical role in body iron homeostasis.	Iron	91-95	solute carrier family 40 member 1	Homo sapiens	0-7
23506870-12	2013	The roles of SLC11A2 and/or SLC40A1 in iron-associated disorders such as hemochromatosis, neurodegenerative diseases, and breast cancer are also summarized.	Iron	39-43	solute carrier family 11 member 2	Homo sapiens	13-20
23506870-12	2013	The roles of SLC11A2 and/or SLC40A1 in iron-associated disorders such as hemochromatosis, neurodegenerative diseases, and breast cancer are also summarized.	Iron	39-43	solute carrier family 40 member 1	Homo sapiens	28-35
23472033-1	2013	Ovotransferrin is one of the major egg white proteins that have antimicrobial activity as well as iron binding capability.	Iron	98-102	transferrin (ovotransferrin)	Gallus gallus	0-14
23472033-11	2013	The isolated ovotransferrin can be used as is or after modifications for various applications such as antimicrobial treatments, anticancer treatments, and iron-supplementing agents for humans.	Iron	155-159	transferrin (ovotransferrin)	Gallus gallus	13-27
23637640-0	2013	Aconitase causes iron toxicity in Drosophila pink1 mutants.	Iron	17-21	Mitochondrial aconitase 1	Drosophila melanogaster	0-9
23637640-0	2013	Aconitase causes iron toxicity in Drosophila pink1 mutants.	Iron	17-21	PTEN-induced putative kinase 1	Drosophila melanogaster	45-50
23926451-8	2013	Based on Nissl and iron staining, a single VEGF injection reduced the injury score, compared to the animals that underwent MCAO and PBS injection.	Iron	19-23	vascular endothelial growth factor A	Rattus norvegicus	43-47
23628042-1	2013	Disorders of iron utilization caused by abnormal elevation of hepcidin levels are the main mechanism of anemia of chronic disease.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	62-70
22424293-2	2013	There is evidence that tumors possess altered iron homeostasis, which is mediated by the perturbed expression of iron-related proteins, for example, transferrin receptor 1, ferritin and ferroportin 1.	Iron	46-50	solute carrier family 40 member 1	Homo sapiens	186-199
22424293-2	2013	There is evidence that tumors possess altered iron homeostasis, which is mediated by the perturbed expression of iron-related proteins, for example, transferrin receptor 1, ferritin and ferroportin 1.	Iron	113-117	solute carrier family 40 member 1	Homo sapiens	186-199
22462691-0	2013	The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.	Iron	4-8	phosphatase and tensin homolog	Homo sapiens	63-67
23478437-4	2013	We found that Sirt2 knock down changed expression of 340 genes, which are mainly involved in cellular processes including actin binding, cellular amino acid metabolic process, transmembrane receptor protein serine/threonine kinase signaling, ferrous iron transport, protein transport and localization, cell morphogenesis, and functions associated with endosome membrane and the trans-Golgi network.	Iron	250-254	sirtuin 2	Homo sapiens	14-19
23485291-1	2013	Following the recent work of decomposing the total dipole moment and polarizability of a homogeneous system into site-specific contributions, we extend the study to the heterogeneous systems of iron-doped Sin (n = 1-14) clusters by introducing a weighting function.	Iron	194-198	embryonal Fyn-associated substrate	Homo sapiens	205-208
23485291-8	2013	Comparing with pure Sin clusters, the polarizabilities of Si atoms are increased after Fe atom doping.	Iron	87-89	embryonal Fyn-associated substrate	Homo sapiens	20-23
23281632-6	2013	The greater suppression of hepcidin-25 by DPO-alpha may facilitate iron mobilization, resulting in diminution of body iron stores without any significant effect on serum iron utilizable for erythropoiesis.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	27-35
23281632-6	2013	The greater suppression of hepcidin-25 by DPO-alpha may facilitate iron mobilization, resulting in diminution of body iron stores without any significant effect on serum iron utilizable for erythropoiesis.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	27-35
23281632-6	2013	The greater suppression of hepcidin-25 by DPO-alpha may facilitate iron mobilization, resulting in diminution of body iron stores without any significant effect on serum iron utilizable for erythropoiesis.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	27-35
23403918-9	2013	Results have shown that the amount of IGFBP-3 involved in the complex formation with Tf in healthy persons was 5.4 +- 1.02 nM and iron ions were substantial for their formation and isolation without employment of harsh conditions.	Iron	130-134	insulin like growth factor binding protein 3	Homo sapiens	38-45
23403918-10	2013	The amount of IGFBP-3-Tf complexes was further determined in persons with iron over-load, patients with iron-deficiency anemia and patients with colorectal carcinoma-associated anemia.	Iron	74-78	insulin like growth factor binding protein 3	Homo sapiens	14-21
23403918-13	2013	IGFBP-3, thus, appears to be a member of a network of iron-binding proteins that participates in cell signaling that involves iron-associated response.	Iron	54-58	insulin like growth factor binding protein 3	Homo sapiens	0-7
23403918-13	2013	IGFBP-3, thus, appears to be a member of a network of iron-binding proteins that participates in cell signaling that involves iron-associated response.	Iron	126-130	insulin like growth factor binding protein 3	Homo sapiens	0-7
23433094-1	2013	BACKGROUND: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron metabolism, and erythropoiesis in chronic hemodialysis (CHD).	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	181-189
23433094-1	2013	BACKGROUND: Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron metabolism, and erythropoiesis in chronic hemodialysis (CHD).	Iron	214-218	hepcidin antimicrobial peptide	Homo sapiens	181-189
23411732-0	2013	Inhibiting the hepcidin inhibitor for treatment of iron overload.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	15-23
23264625-1	2013	alpha-Hemoglobin stabilizing protein (AHSP) is a molecular chaperone that binds monomeric alpha-subunits of human hemoglobin A (HbA) and modulates heme iron oxidation and subunit folding states.	Iron	152-156	alpha hemoglobin stabilizing protein	Homo sapiens	0-36
23264625-1	2013	alpha-Hemoglobin stabilizing protein (AHSP) is a molecular chaperone that binds monomeric alpha-subunits of human hemoglobin A (HbA) and modulates heme iron oxidation and subunit folding states.	Iron	152-156	alpha hemoglobin stabilizing protein	Homo sapiens	38-42
23264625-8	2013	Hexacoordination in the AHSP met-alpha complex markedly decreases the rate of the initial H(2)O(2) reaction with iron and thus provides alpha-subunits protection against damaging oxidative reactions.	Iron	113-117	alpha hemoglobin stabilizing protein	Homo sapiens	24-28
23298407-4	2013	Therefore, the heterostructure nanocomposites of LiF/Fe/Graphene with nano-LiF and ultrafine Fe homogeneously anchored on graphene sheets could open up a novel avenue for the application of iron fluorides as high-performance cathode materials for lithium-ion batteries.	Iron	53-55	LIF interleukin 6 family cytokine	Homo sapiens	75-78
23335357-0	2013	Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia.	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
23335357-1	2013	Levels of hepcidin, a major regulator of iron homeostasis, may identify patients with iron deficiency anemia (IDA) who will not respond to oral iron therapy.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	10-18
23335357-1	2013	Levels of hepcidin, a major regulator of iron homeostasis, may identify patients with iron deficiency anemia (IDA) who will not respond to oral iron therapy.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	10-18
23335357-4	2013	Screening hepcidin levels were 38.4 versus 11.3 ng/mL, P = 0.0002 in nonresponders versus responders to a trial of oral iron.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	10-18
23335357-5	2013	Hepcidin of &gt; 20 ng/mL, showed sensitivity of 41.3%, specificity of 84.4%, and positive predictive value of 81.6% for predicting nonresponsiveness to oral iron.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	0-8
23335357-9	2013	We conclude that hepcidin predicts nonresponsiveness to oral iron in patients with IDA and is superior to TSAT or ferritin for this purpose.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	17-25
22241739-2	2013	In addition, iron metabolism is controlled by several local regulatory mechanisms including IRP and Hif-2alpha activities independently of hepcidin.	Iron	13-17	endothelial PAS domain protein 1	Mus musculus	100-110
22875629-9	2013	An acute high iron diet in wild-type mice or chronically iron-overloaded Bone morphogenetic protein 6-null mice did not significantly lower serum soluble hemojuvelin concentrations.	Iron	57-61	bone morphogenetic protein 6	Mus musculus	73-101
23469783-4	2013	Changes in cell proliferation and apoptosis after iron overload were measured through population double time(DT)and annexin V-PI assay.	Iron	50-54	annexin A5	Homo sapiens	116-125
23303856-1	2013	OBJECTIVE: The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD).	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	82-110
23303856-1	2013	OBJECTIVE: The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD).	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	112-116
22627267-1	2013	A decade ago, hepcidin, an antimicrobial peptide with iron-regulatory properties, was discovered and proposed as playing a significant role in the pathogenesis of anemia of chronic disease.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	14-22
22627267-2	2013	Subsequent studies have demonstrated that hepcidin is the keystone of the linked systems of iron balance and iron transport in health and in disease.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	42-50
22627267-2	2013	Subsequent studies have demonstrated that hepcidin is the keystone of the linked systems of iron balance and iron transport in health and in disease.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	42-50
22627267-3	2013	The definition of the role of hepcidin and its regulation has permitted the mechanisms of disorders of iron homeostasis to be understood at a molecular level.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	30-38
23293203-2	2013	Iron overload was induced by intraperitoneal administration of iron-dextran into mice and resulting liver damage was manifested by significant rise in serum enzyme markers (ALT, AST, ALP and bilirubin) and reduction in liver antioxidants (SOD, CAT, GST and GSH).	Iron	0-4	glutamic pyruvic transaminase, soluble	Mus musculus	173-176
24312736-13	2013	These mechanisms are not well understood, but may include altered iron metabolism by a reduction in hepcidin levels.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	100-108
23036321-4	2013	Granular activated carbon was added as cathode to form macroscopic galvanic cells between Fe(0) and GAC and enhance the current efficiency of the Fe(0)/GAC micro-electrolysis system.	Iron	146-151	glutaminase	Homo sapiens	152-155
23036321-5	2013	The GAC could only adsorb the pollutant and provide buffer capacity for the Fe(0)/GAC micro-electrolysis system, and the macroscopic galvanic cells of the Fe(0)/GAC micro-electrolysis system played a leading role in degradation of 3,3"-iminobis-propanenitrile.	Iron	76-81	glutaminase	Homo sapiens	4-7
23036321-5	2013	The GAC could only adsorb the pollutant and provide buffer capacity for the Fe(0)/GAC micro-electrolysis system, and the macroscopic galvanic cells of the Fe(0)/GAC micro-electrolysis system played a leading role in degradation of 3,3"-iminobis-propanenitrile.	Iron	155-160	glutaminase	Homo sapiens	4-7
23036321-6	2013	With the analysis of the degradation products with GC-MS, possible reaction pathway for the degradation of 3,3"-iminobis-propanenitrile by the Fe(0)/GAC micro-electrolysis system was suggested.	Iron	143-148	glutaminase	Homo sapiens	149-152
23879590-3	2013	The inflammatory cytokine IL-6 is frequently up-regulated in Hodgkin"s lymphoma, and IL-6 levels are strongly associated with hepcidin, the main regulator of iron metabolism.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	126-134
23879590-4	2013	Elevated hepcidin levels result in iron restriction and signs of anemia of chronic disease.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	9-17
24002954-2	2013	Hepcidin could be a major contributor to poor iron status observed in the obese population.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
23095116-9	2013	CONCLUSIONS: We for the first time documented high levels of serum s-HJV in CDA I patients, suggesting that it may contribute to iron loading pathology in CDA I and eventually in other anemias with ineffective erythropoiesis.	Iron	129-133	hemojuvelin BMP co-receptor	Homo sapiens	69-72
23548757-3	2013	In the present study, considering the major role that hepcidin plays in the regulation of iron metabolism and as an inflammatory marker, we investigated hepcidin in PCOS patients and its role in predicting cardiovascular disease (CVD) development.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	54-62
24319154-2	2013	The liver peptide hepcidin controls iron flux to plasma from enterocytes and macrophages through degradation of the cellular iron exporter ferroportin.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	18-26
24319154-2	2013	The liver peptide hepcidin controls iron flux to plasma from enterocytes and macrophages through degradation of the cellular iron exporter ferroportin.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	18-26
24319154-3	2013	The hepcidin-ferroportin axis is essential to maintaining iron homeostasis.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	4-12
24319154-4	2013	Genetic inactivation of proteins of the hepcidin-activating pathway causes iron overload of varying severity in human and mice.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	40-48
24319154-5	2013	Hepcidin insufficiency and increased iron absorption are also characteristic of anemia due to ineffective erythropoiesis in which, despite high total body iron, hepcidin is suppressed by the high erythropoietic activity, worsening both iron overload and anemia in a vicious cycle.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	161-169
24319154-5	2013	Hepcidin insufficiency and increased iron absorption are also characteristic of anemia due to ineffective erythropoiesis in which, despite high total body iron, hepcidin is suppressed by the high erythropoietic activity, worsening both iron overload and anemia in a vicious cycle.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	0-8
24319154-5	2013	Hepcidin insufficiency and increased iron absorption are also characteristic of anemia due to ineffective erythropoiesis in which, despite high total body iron, hepcidin is suppressed by the high erythropoietic activity, worsening both iron overload and anemia in a vicious cycle.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	0-8
24319245-2	2013	Hepcidin deficiency, the hallmark of the disorder, leads to dysregulated intestinal iron absorption and progressive iron deposition in the liver, heart, skin, endocrine glands, and joints.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	0-8
24319245-2	2013	Hepcidin deficiency, the hallmark of the disorder, leads to dysregulated intestinal iron absorption and progressive iron deposition in the liver, heart, skin, endocrine glands, and joints.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	0-8
23653861-11	2013	Compared with patients without stainable iron, those with iron overload had decreased ratios of hepcidin mRNA to serum ferritin.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	96-104
23653861-11	2013	Compared with patients without stainable iron, those with iron overload had decreased ratios of hepcidin mRNA to serum ferritin.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	96-104
22945607-11	2013	This may be due to their higher hepcidin concentrations reducing iron absorption.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	32-40
23812204-0	2013	Effectiveness of oral iron chelator treatment with deferasirox in an aceruloplasminemia patient with a novel ceruloplasmin gene mutation.	Iron	22-26	ceruloplasmin	Homo sapiens	70-83
24209437-1	2013	Aceruloplasminemia is an inherited neurodegenerative disorder involving "neurodegeneration with brain iron accumulation," which is caused by genetic defects in the ceruloplasmin gene.	Iron	102-106	ceruloplasmin	Mus musculus	1-14
23292909-6	2013	RESULTS: In children with IDA, the decrease seen in serum leptin levels after the iron treatment was not statistically significant.	Iron	82-86	leptin	Homo sapiens	58-64
23292909-7	2013	However, the increase seen in serum hepcidin levels after the iron treatment was statistically significant (P = 0.038).	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	36-44
23292909-8	2013	Hepcidin levels were significantly higher in children with IDA who received iron treatment compared to healthy children (P = 0.008).	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
23292909-10	2013	CONCLUSION: Serum ghrelin and hepcidin levels increase with iron treatment in children with IDA.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	30-38
23292909-11	2013	In view of the higher serum ghrelin and hepcidin levels after iron treatment when compared to pretreatment levels and the healthy children, we suggest that the iron treatment has an important role in serum hepcidin and ghrelin synthesis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	40-48
23292909-11	2013	In view of the higher serum ghrelin and hepcidin levels after iron treatment when compared to pretreatment levels and the healthy children, we suggest that the iron treatment has an important role in serum hepcidin and ghrelin synthesis.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	206-214
23292909-11	2013	In view of the higher serum ghrelin and hepcidin levels after iron treatment when compared to pretreatment levels and the healthy children, we suggest that the iron treatment has an important role in serum hepcidin and ghrelin synthesis.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	40-48
23292909-11	2013	In view of the higher serum ghrelin and hepcidin levels after iron treatment when compared to pretreatment levels and the healthy children, we suggest that the iron treatment has an important role in serum hepcidin and ghrelin synthesis.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	206-214
23164231-8	2013	These findings indicated that the osteogenic activity of LF decreases with increasing iron saturation level in vitro and in vivo, which may be related to conformational changes in LF.	Iron	86-90	lactotransferrin	Mus musculus	57-59
22819549-0	2013	Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	62-70
22819549-7	2013	These results suggest that glucose acts as a regulator of serum iron concentrations, most likely by triggering the release of hepcidin from beta-cells.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	126-134
23282250-4	2013	The systemic iron regulatory hormone, hepcidin, has since been identified as a key regulator of iron homeostasis.	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	38-46
23555700-6	2013	Copper deficiency resulted in anemia, increased duodenal hypoxia and Hypoxia inducible factor 2alpha (HIF-2alpha) levels, a regulator of iron absorption.	Iron	137-141	endothelial PAS domain protein 1	Mus musculus	69-100
23555700-6	2013	Copper deficiency resulted in anemia, increased duodenal hypoxia and Hypoxia inducible factor 2alpha (HIF-2alpha) levels, a regulator of iron absorption.	Iron	137-141	endothelial PAS domain protein 1	Mus musculus	102-112
23555700-8	2013	Alleviation of copper-dependent anemia with intraperitoneal copper injection resulted in down regulation of HIF-2alpha-regulated iron absorption genes in the gut.	Iron	129-133	endothelial PAS domain protein 1	Mus musculus	108-118
23555700-9	2013	Our work identifies HIF-2alpha as an important regulator of iron transport machinery in copper deficiency.	Iron	60-64	endothelial PAS domain protein 1	Mus musculus	20-30
23565256-4	2013	Here we showed that induction of hepcidin expression in hepatocytes by dietary iron is associated with an elevation of Bmp6 mRNA in the non-parenchymal cells of the liver.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	33-41
23460869-0	2013	Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	122-130
23460869-5	2013	Inflammation (C-reactive protein and interleukin-6) and iron status (serum ferritin, zinc protoporphyrin and soluble transferrin receptor) were significant predictors of serum hepcidin, explaining nearly 60% of its variance.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	176-184
23460869-10	2013	We propose gender-specific reference values for serum hepcidin in iron-replete infants without inflammation.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	54-62
24730134-0	2013	Iron bacterial phylogeny and their execution towards iron availability in Equatorial Indian Ocean and coastal Arabian Sea.	Iron	0-4	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	118-121
24730134-0	2013	Iron bacterial phylogeny and their execution towards iron availability in Equatorial Indian Ocean and coastal Arabian Sea.	Iron	53-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	118-121
23662181-2	2013	Iron deficiency in the absence of anemia (1) is common in patients with IPAH; (2) is associated with inappropriately raised levels of hepcidin, the key regulator of iron homeostasis; and (3) correlates with disease severity and worse clinical outcomes.	Iron	165-169	hepcidin antimicrobial peptide	Homo sapiens	134-142
23662181-3	2013	Oral iron absorption may be impeded by reduced absorption due to elevated hepcidin levels.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	74-82
22595534-4	2013	Hepcidin, a 25 amino-acid peptide synthesized in hepatocytes, secreted in plasma and rapidly removed in urines, is a negative regulator of both intestinal iron absorption and heme iron recycling by macrophages.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	0-8
22595534-4	2013	Hepcidin, a 25 amino-acid peptide synthesized in hepatocytes, secreted in plasma and rapidly removed in urines, is a negative regulator of both intestinal iron absorption and heme iron recycling by macrophages.	Iron	180-184	hepcidin antimicrobial peptide	Homo sapiens	0-8
22595534-5	2013	Hepcidin synthesis is stimulated by iron or by inflammation (mostly by IL-6) and is repressed by iron deficiency and by all conditions that stimulate bone marrow erythropoiesis such as anemia, bleeding, hemolysis, dyserythropoiesis or erythropoietin injections.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
22595534-6	2013	A defect in the activation of hepcidin normally triggered by iron excess is the underlying mechanism for all juvenile or adult forms of hemochromatosis whereas a defect in hepcidin repression is responsible for an iron deficiency iron refractory anemia (IRIDA).	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	30-38
22595534-9	2013	The validation of hepcidin assays in a near future will allow identifying the patients most likely to benefit from intravenous iron therapy.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	18-26
22621856-1	2013	During the past 10 years, the knowledge of iron metabolism has been revolutionized by the discovery of the main regulatory hormone of body iron: hepcidin.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	145-153
22621856-1	2013	During the past 10 years, the knowledge of iron metabolism has been revolutionized by the discovery of the main regulatory hormone of body iron: hepcidin.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	145-153
23375326-2	2013	Hepcidin, produced by hepatocytes in response to anemia, hypoxia, or inflammation, is a key regulator of iron homeostasis.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	0-8
23375327-1	2013	INTRODUCTION: Hemojuvelin plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway.	Iron	112-116	hemojuvelin BMP co-receptor	Homo sapiens	14-25
23375327-1	2013	INTRODUCTION: Hemojuvelin plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	71-79
23375327-2	2013	Dietary iron sensing and inflammatory pathways converge in the regulation of the key regulator hepcidin.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	95-103
24175256-0	2012	Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	0-8
24175256-1	2012	The anemia of chronic kidney disease and hemodialysis is characterized by chronic inflammation and release of cytokines, resulting in the upregulation of the iron hormone hepcidin, also increased by iron therapy and reduced glomerular filtration, with consequent reduction in iron absorption, recycling, and availability to the erythron.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	171-179
24175256-1	2012	The anemia of chronic kidney disease and hemodialysis is characterized by chronic inflammation and release of cytokines, resulting in the upregulation of the iron hormone hepcidin, also increased by iron therapy and reduced glomerular filtration, with consequent reduction in iron absorption, recycling, and availability to the erythron.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	171-179
24175256-1	2012	The anemia of chronic kidney disease and hemodialysis is characterized by chronic inflammation and release of cytokines, resulting in the upregulation of the iron hormone hepcidin, also increased by iron therapy and reduced glomerular filtration, with consequent reduction in iron absorption, recycling, and availability to the erythron.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	171-179
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	100-108
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	232-245
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	100-108
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	100-108
24175256-3	2012	Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	100-108
24175256-4	2012	However, in hemodialysis patients, carriage of HFE mutations may confer an adaptive benefit by decreasing hepcidin release in response to iron infusion and inflammation, thereby improving iron availability to erythropoiesis, anemia control, the response to Epo, and possibly survival.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	106-114
24175256-4	2012	However, in hemodialysis patients, carriage of HFE mutations may confer an adaptive benefit by decreasing hepcidin release in response to iron infusion and inflammation, thereby improving iron availability to erythropoiesis, anemia control, the response to Epo, and possibly survival.	Iron	188-192	hepcidin antimicrobial peptide	Homo sapiens	106-114
24175256-6	2012	However, HFE mutations directly favor hemoglobinization independently of hepcidin, and reduce macrophages activation in response to inflammation, whereas hepcidin might also play a beneficial anti-inflammatory and anti-microbic action during sepsis, so that direct inhibition of HFE-mediated regulation of iron metabolism may represent a valuable alternative therapeutic target.	Iron	306-310	hepcidin antimicrobial peptide	Homo sapiens	154-162
23001680-1	2012	Apo-form of human lactoferrin (LF) is a potent iron chelator, this feature being similar to the iron-binding properties of a synthetic chelator desferoxamine (DFO).	Iron	47-51	aminopeptidase O (putative)	Homo sapiens	0-3
23001680-1	2012	Apo-form of human lactoferrin (LF) is a potent iron chelator, this feature being similar to the iron-binding properties of a synthetic chelator desferoxamine (DFO).	Iron	96-100	aminopeptidase O (putative)	Homo sapiens	0-3
23065424-1	2012	Iron homeostasis is controlled by hepcidin (Hpc) as well as other ways.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	34-42
23065424-1	2012	Iron homeostasis is controlled by hepcidin (Hpc) as well as other ways.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	44-47
23065424-2	2012	Hpc expression is regulated by iron (Fe) storage and by inflammation, but the joint effect of both stimuli remains unclear.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-3
23065424-2	2012	Hpc expression is regulated by iron (Fe) storage and by inflammation, but the joint effect of both stimuli remains unclear.	Iron	37-39	hepcidin antimicrobial peptide	Homo sapiens	0-3
23065424-3	2012	We studied the modulatory role of inflammatory agents (IL6 and LPS) over Hpc and DMT1 mRNA expression in HepG2 cells preloaded with Fe.	Iron	132-134	doublesex and mab-3 related transcription factor 1	Homo sapiens	81-85
23320008-2	2012	Hepcidin, a peptide hormone produced in the liver, is a central regulator of systemic iron metabolism.	Iron	86-90	hepcidin antimicrobial peptide	Homo sapiens	0-8
23320008-10	2012	Serum hepcidin levels were significantly correlated with ferritin, transferrin saturation, and hemoglobin levels and significantly negatively correlated with sTfR level and total iron binding capacity (P&lt;0.0001).	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	6-14
23320008-11	2012	CONCLUSION: Serum hepcidin levels are significantly associated with iron status and can be a useful indicator of ID.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	18-26
22833619-1	2012	BACKGROUND: Hepcidin is associated with iron-restricted erythropoiesis.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	12-20
22833619-2	2012	A previous cross-sectional study showed that serum hepcidin-25 levels are negatively associated with the hemoglobin concentration in non-dialysis chronic kidney disease (CKD) patients with sufficient iron stores.	Iron	200-204	hepcidin antimicrobial peptide	Homo sapiens	51-59
22833619-10	2012	CONCLUSIONS: Higher hepcidin-25 levels predict the progression of anemia in non-dialysis CKD patients with sufficient iron stores, indicating the involvement of hepcidin in the progression of anemia in non-dialysis CKD patients.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	20-28
23355942-4	2012	The aim of this study was to establish short-term effects of iron supplementation on the hemoglobin content of reticulocytes (Ret-He) and red blood cells (RBC-He) in case of suspected iron deficient erythropoiesis (IDE) in the third trimester of pregnancy.	Iron	61-65	ret proto-oncogene	Homo sapiens	126-129
23355942-6	2012	After iron supplementation, reticulocyte counts increased from 0.061+-0.015x10(12)/L to 0.079+-0.026x10(12)/L and Ret-He increased from 23.6+-2.8 pg to 28.3+-2.6 pg (P=&lt;0.001).	Iron	6-10	ret proto-oncogene	Homo sapiens	114-117
23175344-6	2012	It seems that a key role in the transport of iron between mother and fetus is plays by hepcidin and, described in 2010 zyklopen.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	87-95
23139325-3	2012	Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of iron metabolism.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	0-8
23139325-4	2012	Hepcidin controls the absorption of dietary iron and the distribution of iron among cell types in the body, and its synthesis is regulated by both iron and innate immunity.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
23139325-4	2012	Hepcidin controls the absorption of dietary iron and the distribution of iron among cell types in the body, and its synthesis is regulated by both iron and innate immunity.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
23139325-4	2012	Hepcidin controls the absorption of dietary iron and the distribution of iron among cell types in the body, and its synthesis is regulated by both iron and innate immunity.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
23139325-5	2012	We describe how hepcidin integrates signals from diverse physiological inputs, forming a key molecular bridge between iron trafficking and response to infection.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	16-24
23075938-5	2012	Future studies should clarify whether dietary or other therapeutic interventions to mitigate inflammation attenuate hepcidin-mediated declines in Fe status.	Iron	146-148	hepcidin antimicrobial peptide	Homo sapiens	116-124
22689680-7	2012	Hepcidin response to acute malaria supports the notion of iron sequestration during acute malaria infection and suggests that iron administration during acute malaria is futile.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
22689680-7	2012	Hepcidin response to acute malaria supports the notion of iron sequestration during acute malaria infection and suggests that iron administration during acute malaria is futile.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	0-8
22689680-8	2012	These data suggest iron supplementation policies should take into account the high hepcidin levels and probable poor utilization of iron for up to one week after treatment for the majority of patients with acute malaria.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	83-91
22728873-1	2012	BACKGROUND &amp; AIMS: The hereditary hemochromatosis-associated membrane proteins HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone hepcidin.	Iron	154-158	transferrin receptor 2	Homo sapiens	88-92
22728873-1	2012	BACKGROUND &amp; AIMS: The hereditary hemochromatosis-associated membrane proteins HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone hepcidin.	Iron	154-158	hemojuvelin BMP co-receptor	Homo sapiens	98-101
22728873-1	2012	BACKGROUND &amp; AIMS: The hereditary hemochromatosis-associated membrane proteins HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone hepcidin.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	167-175
22728873-7	2012	Our experiments show that like TfR2, HJV competes with TfR1 for binding to HFE, indicating that the expression of TfR2 and HJV may be critical for iron sensing.	Iron	147-151	transferrin receptor 2	Homo sapiens	31-35
22728873-7	2012	Our experiments show that like TfR2, HJV competes with TfR1 for binding to HFE, indicating that the expression of TfR2 and HJV may be critical for iron sensing.	Iron	147-151	hemojuvelin BMP co-receptor	Homo sapiens	37-40
22728873-7	2012	Our experiments show that like TfR2, HJV competes with TfR1 for binding to HFE, indicating that the expression of TfR2 and HJV may be critical for iron sensing.	Iron	147-151	transferrin receptor 2	Homo sapiens	114-118
22728873-7	2012	Our experiments show that like TfR2, HJV competes with TfR1 for binding to HFE, indicating that the expression of TfR2 and HJV may be critical for iron sensing.	Iron	147-151	hemojuvelin BMP co-receptor	Homo sapiens	123-126
22907951-6	2012	In HD patients, Gas6 levels were elevated compared with controls (P &lt; 0.001) and positively associated with low albumin (r = 0.33; P = 0.01), dialysis vintage (r = 0.36; P = 0.008) and IV iron administration (r = 0.33; P = 0.01).	Iron	191-195	growth arrest specific 6	Homo sapiens	16-20
22907951-9	2012	Low albumin and higher IV iron administration were associated with higher Gas6 levels, suggesting a possible connection between inflammation and oxidative stress mediated by iron.	Iron	26-30	growth arrest specific 6	Homo sapiens	74-78
22907951-9	2012	Low albumin and higher IV iron administration were associated with higher Gas6 levels, suggesting a possible connection between inflammation and oxidative stress mediated by iron.	Iron	174-178	growth arrest specific 6	Homo sapiens	74-78
23066366-7	2012	Whether these associations are causal and are driven by hypoxia-inducible factor and hepcidin-mediated upregulation of demand for iron warrants further investigation.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	85-93
22915593-0	2012	A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast.	Iron	11-15	Yap5p	Saccharomyces cerevisiae S288C	74-78
22915593-0	2012	A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast.	Iron	94-98	Yap5p	Saccharomyces cerevisiae S288C	74-78
22915593-1	2012	Yeast respond to increased cytosolic iron by activating the transcription factor Yap5 increasing transcription of CCC1, which encodes a vacuolar iron importer.	Iron	37-41	Yap5p	Saccharomyces cerevisiae S288C	81-85
22915593-1	2012	Yeast respond to increased cytosolic iron by activating the transcription factor Yap5 increasing transcription of CCC1, which encodes a vacuolar iron importer.	Iron	145-149	Yap5p	Saccharomyces cerevisiae S288C	81-85
22915593-2	2012	Using a genetic screen to identify genes involved in Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondrial chaperone involved in iron-sulfur cluster synthesis, prevented expression of Yap5 target genes.	Iron	58-62	Yap5p	Saccharomyces cerevisiae S288C	53-57
22915593-2	2012	Using a genetic screen to identify genes involved in Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondrial chaperone involved in iron-sulfur cluster synthesis, prevented expression of Yap5 target genes.	Iron	58-62	Yap5p	Saccharomyces cerevisiae S288C	218-222
22915593-2	2012	Using a genetic screen to identify genes involved in Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondrial chaperone involved in iron-sulfur cluster synthesis, prevented expression of Yap5 target genes.	Iron	163-167	Yap5p	Saccharomyces cerevisiae S288C	53-57
22915593-2	2012	Using a genetic screen to identify genes involved in Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondrial chaperone involved in iron-sulfur cluster synthesis, prevented expression of Yap5 target genes.	Iron	163-167	Yap5p	Saccharomyces cerevisiae S288C	218-222
22915593-3	2012	We demonstrated that mutation or reduced expression of other genes involved in mitochondrial iron-sulfur cluster synthesis (YFH1, ISU1) prevented induction of the Yap5 response.	Iron	93-97	Yap5p	Saccharomyces cerevisiae S288C	163-167
22896707-6	2012	Furthermore we found two essential molecules for iron homeostasis, iron-sulfur cluster scaffold protein (ISCU) and transferrin receptor 1 (TfR), are a direct target of miR-210.	Iron	49-53	NFU1 iron-sulfur cluster scaffold	Homo sapiens	67-103
22998881-5	2012	In the cross-sectional study, infused iron, hepcidin, and C-reactive protein values correlated with hepatic iron stores in both univariate analysis (P&lt;.05, Spearman test) and binary logistic regression (P &lt;.05).	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	44-52
23393983-4	2012	The bioaugmentation of the ST3 consortium enhanced Fe accumulation by 247%, Ni by 231% and Zn by 223% in B. juncea as compared to control plants.	Iron	51-53	Sulfotransferase 3	Drosophila melanogaster	27-30
22580996-12	2012	Ineffective erythropoiesis associated with defective erythroid iron utilization due to DMT1 mutations has specific biological and clinical features.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	87-91
22996660-5	2012	Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein.	Iron	16-20	adiponectin, C1Q and collagen domain containing	Mus musculus	88-99
22996660-5	2012	Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein.	Iron	63-67	adiponectin, C1Q and collagen domain containing	Mus musculus	88-99
22996660-7	2012	Further, loss of the adipocyte iron export channel, ferroportin, in mice resulted in adipocyte iron loading, decreased adiponectin, and insulin resistance.	Iron	31-35	adiponectin, C1Q and collagen domain containing	Mus musculus	119-130
23043066-5	2012	In PD Cp concentration and oxidative activity in serum are significantly lowered with iron deposits and lesions in substantia nigra and basal ganglia.	Iron	86-90	ceruloplasmin	Homo sapiens	6-8
22579050-4	2012	Factors contributing to potential iron overload in PCOS include the iron sparing effect of chronic menstrual dysfunction, insulin resistance, and a decrease in hepcidin leading to increased iron absorption.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	160-168
22993514-0	2012	Iron Biofortification and Homeostasis in Transgenic Cassava Roots Expressing the Algal Iron Assimilatory Gene, FEA1.	Iron	0-4	uncharacterized protein	Chlamydomonas reinhardtii	111-115
22306005-5	2012	In the efferent arc, hepcidin regulates intestinal iron absorption, plasma iron concentrations, and tissue iron distribution by inducing degradation of its receptor, the cellular iron exporter ferroportin.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	21-29
22306005-5	2012	In the efferent arc, hepcidin regulates intestinal iron absorption, plasma iron concentrations, and tissue iron distribution by inducing degradation of its receptor, the cellular iron exporter ferroportin.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	21-29
22915735-5	2012	Mice deficient of the c-Rel factor exhibited a marked immunoreactivity for fibrillary alpha-synuclein in the substantia nigra pars compacta as well as increased expression of divalent metal transporter 1 (DMT1) and iron staining in both the substantia nigra pars compacta and striatum.	Iron	215-219	reticuloendotheliosis oncogene	Mus musculus	22-27
22776295-1	2012	Hepcidin is a small disulfide-rich peptide hormone that plays a key role in the regulation of iron homeostasis by binding and mediating the degradation of the cell membrane iron efflux transporter, ferroportin.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	0-8
22962523-11	2012	These results suggest that LF intake is useful for the prevention of renal tubular oxidative damage mediated by iron.	Iron	112-116	lactotransferrin	Rattus norvegicus	27-29
22836558-11	2012	Other non hemo-iron related antioxidant enzymes (e.g. superoxide dismutase, catalase, thioredoxin and peroxiredoxin) are also involved in redox modulation in vascular remodelling.	Iron	15-19	thioredoxin	Homo sapiens	86-97
22751622-2	2012	Treatment of H(2)L2(Ph4) with Fe(OTf)(3) afforded a C(2)-symmetric trinuclear iron(III) complex, [NaFe(3)(L2(Ph4))(2)(mu(3)-O)(mu-O(2)CCPh(3))(2)(H(2)O)(3)](OTf)(2) (8).	Iron	78-82	prolyl 4-hydroxylase, transmembrane	Homo sapiens	20-23
22751622-2	2012	Treatment of H(2)L2(Ph4) with Fe(OTf)(3) afforded a C(2)-symmetric trinuclear iron(III) complex, [NaFe(3)(L2(Ph4))(2)(mu(3)-O)(mu-O(2)CCPh(3))(2)(H(2)O)(3)](OTf)(2) (8).	Iron	78-82	prolyl 4-hydroxylase, transmembrane	Homo sapiens	109-112
22515740-1	2012	Ceruloplasmin contains 95% of the copper in human serum and plays an important role in iron efflux from mammalian cells, including brain cells, due to the activity of ferroxidase, which oxidizes ferrous iron following its transfer to the cell surface via the iron transporter, ferroportin, and delivers ferric iron to extracellular transferrin.	Iron	87-91	ceruloplasmin	Homo sapiens	0-13
22515740-1	2012	Ceruloplasmin contains 95% of the copper in human serum and plays an important role in iron efflux from mammalian cells, including brain cells, due to the activity of ferroxidase, which oxidizes ferrous iron following its transfer to the cell surface via the iron transporter, ferroportin, and delivers ferric iron to extracellular transferrin.	Iron	203-207	ceruloplasmin	Homo sapiens	0-13
22515740-5	2012	Clinical and pathologic studies in patients with aceruloplasminemia and ceruloplasmin knockout mice revealed increased lipid peroxidation due to iron-mediated cellular radical injury which is caused by a marked accumulation of iron in the affected parenchymal tissues such as the retina, liver, pancreas and brain.	Iron	145-149	ceruloplasmin	Homo sapiens	50-63
22515740-5	2012	Clinical and pathologic studies in patients with aceruloplasminemia and ceruloplasmin knockout mice revealed increased lipid peroxidation due to iron-mediated cellular radical injury which is caused by a marked accumulation of iron in the affected parenchymal tissues such as the retina, liver, pancreas and brain.	Iron	227-231	ceruloplasmin	Homo sapiens	50-63
23265420-7	2012	The discovery of the hepcidin-ferroportin  (Fpn) complex, which greatly clarified the enigmatic mechanism that supervises the iron homeostasis, should prompt to a critical review on iron supplementation, ineffective on the expression of the most important proteins of iron metabolism.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	21-29
23265420-7	2012	The discovery of the hepcidin-ferroportin  (Fpn) complex, which greatly clarified the enigmatic mechanism that supervises the iron homeostasis, should prompt to a critical review on iron supplementation, ineffective on the expression of the most important proteins of iron metabolism.	Iron	182-186	hepcidin antimicrobial peptide	Homo sapiens	21-29
23265420-7	2012	The discovery of the hepcidin-ferroportin  (Fpn) complex, which greatly clarified the enigmatic mechanism that supervises the iron homeostasis, should prompt to a critical review on iron supplementation, ineffective on the expression of the most important proteins of iron metabolism.	Iron	182-186	hepcidin antimicrobial peptide	Homo sapiens	21-29
22531233-3	2012	Hepcidin is a central component of blood iron, and ferritin alterations occur during infections.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
22703180-6	2012	These involve the hormone hepcidin and iron regulatory proteins, which collectively ensure iron balance.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	26-34
22669083-5	2012	In the presence of NADH, electrons transferred to phenazine derivant through SWCNT, by analogous means of the electron transport chain formed by a series of iron-sulfur (FeS) clusters in CoI.	Iron	170-173	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	187-190
22842295-3	2012	Hepcidin is a hormone produced by the liver that controls iron metabolism.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
22579918-0	2012	Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells.	Iron	48-52	heme oxygenase 1	Homo sapiens	24-40
22579918-7	2012	Together, our results reveal a novel and coordinated adaptive response of nonerythroid cells to sustained HO-1 induction that has an impact on cellular iron homeostasis.	Iron	152-156	heme oxygenase 1	Homo sapiens	106-110
22709961-5	2012	Leaf extracts of Fe-deficient plants also showed increases in citric acid concentration and in the activities of glucose-6-phosphate dehydrogenase and fumarase activities, and decreases in aconitase activity.	Iron	17-19	g6pdh	Hordeum vulgare	113-146
22535765-0	2012	17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	39-47
22535765-2	2012	In the present study, we examined the effects of 17beta-estradiol (E2) on hepcidin, a key negative regulator of iron absorption from the liver.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	74-82
22535765-7	2012	In summary, our data suggest that hepcidin inhibition by E2 is to increase iron uptake, a mechanism to compensate iron loss during menstruation.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	34-42
22535765-7	2012	In summary, our data suggest that hepcidin inhibition by E2 is to increase iron uptake, a mechanism to compensate iron loss during menstruation.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	34-42
28197430-4	2012	An association between serum leptin and total iron binding capacity was observed.	Iron	46-50	leptin	Homo sapiens	29-35
22510500-6	2012	The decrease in hepcidin leads to increased iron absorption from the gut.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	16-24
22555956-1	2012	Hepcidin is known to increase intracellular iron through binding to and degrading ferroportin, which is a transmembrane protein that transports iron from the intracellular to the outside.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
22555956-1	2012	Hepcidin is known to increase intracellular iron through binding to and degrading ferroportin, which is a transmembrane protein that transports iron from the intracellular to the outside.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	0-8
22555956-4	2012	Our data showed that hepcidin (&lt;100 nmol/L) could increase intracellular calcium, and this effect was more significant when cells were exposed to high environmental iron concentrations.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	21-29
22211566-5	2012	Iron sequestration mediated by hepcidin is an underappreciated but common cause of iron-restricted erythropoiesis in patients with chronic inflammatory disease.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	31-39
22211566-5	2012	Iron sequestration mediated by hepcidin is an underappreciated but common cause of iron-restricted erythropoiesis in patients with chronic inflammatory disease.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	31-39
22581044-0	2012	alpha-Synuclein expression is modulated at the translational level by iron.	Iron	70-74	synuclein alpha	Homo sapiens	0-15
22581044-1	2012	Several studies have suggested an interaction between alpha-synuclein protein and iron in Parkinson"s disease.	Iron	82-86	synuclein alpha	Homo sapiens	54-69
22496243-8	2012	When shRNA knocked down hcp1 mRNA, heme-(55)Fe uptake and [(3)H]folate transport mirrored the mRNA decrease, ho1 mRNA increased, and flvcr mRNA was unchanged.	Iron	44-46	solute carrier family 46 member 1	Homo sapiens	24-28
22496243-9	2012	These data argue that HCP1 is involved in low-affinity heme-Fe uptake not just in folate transport.	Iron	60-62	solute carrier family 46 member 1	Homo sapiens	22-26
22517766-2	2012	The regulation of hepcidin (HAMP) gene expression by iron status is mediated in part by the signaling molecule bone morphogenetic protein 6 (BMP6).	Iron	53-57	bone morphogenetic protein 6	Mus musculus	111-139
22517766-2	2012	The regulation of hepcidin (HAMP) gene expression by iron status is mediated in part by the signaling molecule bone morphogenetic protein 6 (BMP6).	Iron	53-57	bone morphogenetic protein 6	Mus musculus	141-145
22682313-5	2012	Among the mechanisms of diseases, obese children often have asthma and high hepcidin levels that may reduce serum iron concentrations.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	76-84
22582705-4	2012	At high pH values (pH &gt;= 6) or in an organic medium, the reduction of the Fe center is easier in the case of the alpha-1 isomer, whereas for the alpha-2 isomer such reduction takes place at more negative potentials, as expected.	Iron	77-79	adrenoceptor alpha 1D	Homo sapiens	116-123
22582705-5	2012	In contrast, at lower pH values (pH &lt;= 5), an inversion of this trend is observed, and the reduction of the Fe center becomes easier for the alpha-2 isomer compared to the alpha-1.	Iron	111-113	adrenoceptor alpha 1D	Homo sapiens	175-182
22249207-1	2012	The Q248H mutation in the gene SLC40A1 which encodes for the cellular iron exporter ferroportin is relatively common in Africa.	Iron	70-74	solute carrier family 40 member 1	Homo sapiens	31-38
22249207-2	2012	This mutation has been associated with resistance to hepcidin and therefore we hypothesized that iron-related parameters and the prevalence of opportunistic infections in HIV might be influenced by the Q248H mutation.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	53-61
22250712-1	2012	Lactoferrin is an 80 kDa iron binding protein found in the secretory fluids of mammals and it plays a major role in host defence.	Iron	25-29	lactotransferrin	Bos taurus	0-11
22292525-3	2012	Bovine lactoferrin (bLf), an emerging important regulator of iron and inflammatory homeostasis, can represent a new therapeutic approach for PTD treatment.	Iron	61-65	lactotransferrin	Bos taurus	7-18
22540735-1	2012	Lactoferrin is an abundant iron-binding protein in milk.	Iron	27-31	lactotransferrin	Bos taurus	0-11
22540735-3	2012	The potent iron-binding properties of lactoferrin can locally create iron deficiency, and this is an important factor in host defense as it prevents bacteria from growing and forming biofilms.	Iron	11-15	lactotransferrin	Bos taurus	38-49
22016365-6	2012	Hepcidin, the key iron-regulating peptide binds to the iron exporter ferroportin and leads to its degradation, thereby inhibiting intestinal iron absorption and cellular export.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	0-8
22016365-6	2012	Hepcidin, the key iron-regulating peptide binds to the iron exporter ferroportin and leads to its degradation, thereby inhibiting intestinal iron absorption and cellular export.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
22016365-6	2012	Hepcidin, the key iron-regulating peptide binds to the iron exporter ferroportin and leads to its degradation, thereby inhibiting intestinal iron absorption and cellular export.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
22440905-8	2012	In iron-challenged, cultured proximal tubule cells, we observed a positive correlation between HO-1 mRNA level and HO-1 release.	Iron	3-7	heme oxygenase 1	Homo sapiens	95-99
22440905-8	2012	In iron-challenged, cultured proximal tubule cells, we observed a positive correlation between HO-1 mRNA level and HO-1 release.	Iron	3-7	heme oxygenase 1	Homo sapiens	115-119
22575541-4	2012	Enterocyte iron is exported to the blood via ferroportin 1 on the basolateral membrane.	Iron	11-15	solute carrier family 40 member 1	Homo sapiens	45-58
22575541-8	2012	Hepcidin expression in turn responds to body iron demands and the BMP-SMAD signaling pathway plays a key role in this process.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
22579041-2	2012	Recent studies demonstrated that three 5" end splice variants of the Atp7a transcript exist in rat duodenum, all of which are strongly induced during iron deprivation.	Iron	150-154	ATPase copper transporting alpha	Rattus norvegicus	69-74
22579041-4	2012	Northern blot analyses using probes generated from the full-length Atp7a cDNA revealed several specific hybridization bands, all of which were more intense in RNA samples extracted from duodenal enterocytes isolated from iron-deficient rats.	Iron	221-225	ATPase copper transporting alpha	Rattus norvegicus	67-72
22866392-1	2012	Iron-impregnated granular activated carbons (Fe-GAC) can remove arsenic effectively from water.	Iron	0-4	glutaminase	Homo sapiens	48-51
22897067-1	2012	INTRODUCTION: Hepcidin plays a key role in the regulation of plasma iron levels through inhibition of iron export from enterocytes and macrophages.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	14-22
22897067-1	2012	INTRODUCTION: Hepcidin plays a key role in the regulation of plasma iron levels through inhibition of iron export from enterocytes and macrophages.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	14-22
22897067-2	2012	Hepcidin is considered a promising marker in the investigation of iron status, especially in patients that still pose a diagnostic challenge, such as infants and patients with chronic (kidney) disease.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
22068728-8	2012	These results also show that hCTR1 is able to transport Fe and Zn.	Iron	56-58	solute carrier family 31 member 1	Homo sapiens	29-34
22180422-10	2012	Hfe-knockout fetuses that express low levels of liver hepcidin accumulated more iron in their liver than wild-type fetuses due to increased ferroportin levels in the placenta.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	54-62
22180422-13	2012	Fetal Hfe is important in regulating placental iron transfer by modulating fetal liver hepcidin expression.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	87-95
22426424-0	2012	Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice.	Iron	35-39	olfactory receptor family 10 subfamily N member 1	Mus musculus	49-52
22426424-1	2012	Based on a multimodal drug design paradigm, we have synthesized a multifunctional non-toxic, brain permeable iron chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase (MAO)-B inhibitor, rasagiline and the antioxidant-iron chelator moiety of an 8-hydroxyquinoline derivative of the iron chelator, VK28.	Iron	109-113	olfactory receptor family 10 subfamily N member 1	Mus musculus	134-137
22426424-1	2012	Based on a multimodal drug design paradigm, we have synthesized a multifunctional non-toxic, brain permeable iron chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase (MAO)-B inhibitor, rasagiline and the antioxidant-iron chelator moiety of an 8-hydroxyquinoline derivative of the iron chelator, VK28.	Iron	288-292	olfactory receptor family 10 subfamily N member 1	Mus musculus	134-137
22426424-1	2012	Based on a multimodal drug design paradigm, we have synthesized a multifunctional non-toxic, brain permeable iron chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase (MAO)-B inhibitor, rasagiline and the antioxidant-iron chelator moiety of an 8-hydroxyquinoline derivative of the iron chelator, VK28.	Iron	288-292	olfactory receptor family 10 subfamily N member 1	Mus musculus	134-137
22426424-3	2012	M30 significantly reduced cerebral iron accumulation as demonstrated by Perl"s staining, accompanied by a marked decrease in cerebral beta-amyloid plaques.	Iron	35-39	olfactory receptor family 10 subfamily N member 1	Mus musculus	0-3
22426424-5	2012	In summary, the present study indicates that the novel MAO inhibitor/iron chelating drug, M30, acting against multiple brain targets could reverse age-associated memory impairment and provide a potential treatment against the progression of neurodegeneration in ageing.	Iron	69-73	olfactory receptor family 10 subfamily N member 1	Mus musculus	90-93
22445852-5	2012	Treatment with either an iron chelator (deferoxamine) or over-expression of ftn-1, encoding the iron sequestering protein ferritin, increased resistance to t-BOOH and, in the latter case, reduced protein oxidation, but did not increase lifespan.	Iron	96-100	Ferritin	Caenorhabditis elegans	76-81
22438062-6	2012	Kinase motifs in Fe-responsive proteins matched to protein kinase A/calcium calmodulin-dependent kinase II, casein kinase II, and proline-directed kinase, indicating a possible critical function of these kinase classes in Fe homeostasis.	Iron	17-19	Protein kinase superfamily protein	Arabidopsis thaliana	108-124
22806010-4	2012	Lf is an iron binding protein produced in mammals that has antimicrobial and immunomodulatory properties.	Iron	9-13	HLF transcription factor, PAR bZIP family member	Homo sapiens	0-2
22806010-6	2012	We found that H. pylori was able to use iron from fully iron-saturated human Lf (hLf) whereas partially iron-saturated hLf (apo) did not increase H. pylori growth.	Iron	40-44	HLF transcription factor, PAR bZIP family member	Homo sapiens	77-79
22806010-6	2012	We found that H. pylori was able to use iron from fully iron-saturated human Lf (hLf) whereas partially iron-saturated hLf (apo) did not increase H. pylori growth.	Iron	40-44	HLF transcription factor, PAR bZIP family member	Homo sapiens	81-84
22806010-6	2012	We found that H. pylori was able to use iron from fully iron-saturated human Lf (hLf) whereas partially iron-saturated hLf (apo) did not increase H. pylori growth.	Iron	56-60	HLF transcription factor, PAR bZIP family member	Homo sapiens	77-79
22806010-6	2012	We found that H. pylori was able to use iron from fully iron-saturated human Lf (hLf) whereas partially iron-saturated hLf (apo) did not increase H. pylori growth.	Iron	56-60	HLF transcription factor, PAR bZIP family member	Homo sapiens	77-79
22294697-8	2012	Therefore, Abcb6 is the sole ATP-dependent porphyrin importer, and loss of Abcb6 produces up-regulation of heme and iron pathways necessary for normal development.	Iron	116-120	ATP-binding cassette, sub-family B (MDR/TAP), member 6	Mus musculus	75-80
22367199-0	2012	Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4.	Iron	46-50	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	115-119
22367199-3	2012	We report here the solution structure and mechanism of novel iron-mediated functional roles of human Dph4, a type III J-protein playing a vital role in diphthamide biosynthesis and normal development.	Iron	61-65	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	101-105
22367199-6	2012	Dph4 exhibits a unique ability to bind iron in tetrahedral coordination geometry through cysteines of its CSL-domain.	Iron	39-43	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	0-4
22367199-8	2012	Iron-bound Dph4 (Fe-Dph4) also undergoes oligomerization, thus potentially functioning as a transient "iron storage protein," thereby regulating the intracellular iron homeostasis.	Iron	0-4	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	11-15
22367199-8	2012	Iron-bound Dph4 (Fe-Dph4) also undergoes oligomerization, thus potentially functioning as a transient "iron storage protein," thereby regulating the intracellular iron homeostasis.	Iron	0-4	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	17-24
22367199-8	2012	Iron-bound Dph4 (Fe-Dph4) also undergoes oligomerization, thus potentially functioning as a transient "iron storage protein," thereby regulating the intracellular iron homeostasis.	Iron	103-107	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	11-15
22367199-8	2012	Iron-bound Dph4 (Fe-Dph4) also undergoes oligomerization, thus potentially functioning as a transient "iron storage protein," thereby regulating the intracellular iron homeostasis.	Iron	103-107	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	17-24
22367199-8	2012	Iron-bound Dph4 (Fe-Dph4) also undergoes oligomerization, thus potentially functioning as a transient "iron storage protein," thereby regulating the intracellular iron homeostasis.	Iron	163-167	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	11-15
22367199-8	2012	Iron-bound Dph4 (Fe-Dph4) also undergoes oligomerization, thus potentially functioning as a transient "iron storage protein," thereby regulating the intracellular iron homeostasis.	Iron	163-167	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	17-24
22367199-10	2012	Further, we observed that Fe-Dph4 is conformationally better poised to perform Hsp70-dependent functions, thus underlining the significance of iron binding in Dph4.	Iron	143-147	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	29-33
22367199-10	2012	Further, we observed that Fe-Dph4 is conformationally better poised to perform Hsp70-dependent functions, thus underlining the significance of iron binding in Dph4.	Iron	143-147	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	159-163
22367199-11	2012	Yeast Jjj3, a functional ortholog of human Dph4 also shows a similar iron-binding property, indicating the conserved nature of iron sequestration across species.	Iron	69-73	DnaJ heat shock protein family (Hsp40) member C24	Homo sapiens	43-47
22500765-3	2012	With the use of confocal single-molecule fluorescence techniques, we demonstrate that small aggregates (oligomers) of alpha-synuclein formed from unbound monomeric species in the presence of organic solvent (DMSO) and iron (Fe(3+)) ions have a high affinity to bind to model membranes, regardless of the lipid-composition or membrane curvature.	Iron	218-222	synuclein alpha	Homo sapiens	118-133
22500765-3	2012	With the use of confocal single-molecule fluorescence techniques, we demonstrate that small aggregates (oligomers) of alpha-synuclein formed from unbound monomeric species in the presence of organic solvent (DMSO) and iron (Fe(3+)) ions have a high affinity to bind to model membranes, regardless of the lipid-composition or membrane curvature.	Iron	224-226	synuclein alpha	Homo sapiens	118-133
22290531-4	2012	Recent advances in our understanding of the molecular mechanisms of iron regulation reveal that increased hepcidin, the iron regulatory hormone, is a key factor in the development of ACD.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	106-114
22290531-5	2012	In this review, we will summarize the role of hepcidin in iron homeostasis, its contribution to the pathophysiology of ACD, and novel strategies that modulate hepcidin and its target ferroportin for the treatment of ACD.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	46-54
22342521-1	2012	Hephaestin (Heph) is a ferroxidase protein that converts ferrous to ferric iron to facilitate cellular iron export by ferroportin.	Iron	75-79	ceruloplasmin	Mus musculus	23-34
22342521-3	2012	In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear.	Iron	114-118	src-like adaptor	Mus musculus	89-92
22198321-9	2012	We also demonstrated that ferroportin1 expression was significantly affected by HIF-1alpha in astrocytes, implying that the gene encoding this iron efflux protein might be a hypoxia-inducible one.	Iron	143-147	solute carrier family 40 member 1	Homo sapiens	26-38
21947861-1	2012	Divalent metal transporter 1 (DMT1) is likely responsible for the release of iron from endosomes to the cytoplasm in placental syncytiotrophoblasts (STB).	Iron	77-81	solute carrier family 11 member 2	Homo sapiens	0-28
21947861-1	2012	Divalent metal transporter 1 (DMT1) is likely responsible for the release of iron from endosomes to the cytoplasm in placental syncytiotrophoblasts (STB).	Iron	77-81	solute carrier family 11 member 2	Homo sapiens	30-34
21947861-2	2012	To determine the localization and the regulation of DMT1 expression by iron directly in placenta, the expression of DMT1 in human term placental tissues and BeWo cells (human placental choriocarcinoma cell line) was detected and the change in expression in response to different iron treatments on BeWo cells was observed.	Iron	71-75	solute carrier family 11 member 2	Homo sapiens	52-56
21947861-5	2012	Further, DMT1 mRNA responded more significantly to treatments if it possessed an iron-responsive element than mRNA without this element.	Iron	81-85	solute carrier family 11 member 2	Homo sapiens	9-13
21947861-6	2012	This study indicated that DMT1 is likely involved in endosomal iron transport in placental STB and placental DMT1 + IRE expression was primarily regulated by the IRE/IRP mechanism.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	26-30
22170436-10	2012	It indicates that FPN1 may participate in placental iron transport, and placental FPN1 expression is obviously not dependent on the iron regular element/iron regular protein regulation.	Iron	52-56	solute carrier family 40 member 1	Homo sapiens	18-22
22170436-11	2012	An alternatively spliced FPN1 isoform that lacks an iron regular element may be the predominant expression in BeWo cells.	Iron	52-56	solute carrier family 40 member 1	Homo sapiens	25-29
22280874-9	2012	In the RRMS group, the iron concentration in the bilateral head of the caudate nucleus (HCN) (left: p&lt;0.0001; right: p=0.0134) and the dentate nucleus (DN) (p&lt;0.05 for both) were correlated with disease duration.	Iron	23-27	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	88-91
22171070-0	2012	HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis.	Iron	49-53	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	0-5
22171070-0	2012	HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis.	Iron	84-88	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	0-5
22171070-8	2012	Knockdown of HSC20 altered cytosolic and mitochondrial iron pools and increased the expression of transferrin receptor 1 and iron regulatory protein 2 consistent with decreased iron bioavailability.	Iron	55-59	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	13-18
22171070-8	2012	Knockdown of HSC20 altered cytosolic and mitochondrial iron pools and increased the expression of transferrin receptor 1 and iron regulatory protein 2 consistent with decreased iron bioavailability.	Iron	125-129	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	13-18
22171070-9	2012	These results indicate that HSC20 interacts with frataxin structurally and functionally and is important for ISC biogenesis and iron homeostasis in mammals.	Iron	128-132	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	28-33
21618415-2	2012	IRIDA is characterized by hypochromic microcytic anemia unresponsive to oral iron treatment, low transferrin saturation, and a high level of iron-regulated hormone hepcidin.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	164-172
22364386-1	2012	Iron release in vitro from human serum diferric transferrin (hFe(2)Tf) in acidic media (4.2 &lt;= pH &lt;= 5.4) in the presence of nonsynergistic anions occurs in at least five kinetic steps.	Iron	0-4	hemojuvelin BMP co-receptor	Homo sapiens	61-69
22262835-10	2012	The generation of dinitrosyl-dithiol-iron complexes acts as a common currency for NO transport and storage by MRP1 and GST P1-1, respectively.	Iron	37-41	glutathione S-transferase pi 1	Homo sapiens	119-127
22192713-5	2012	Hepcidin is the master regulator of iron metabolism, and this peptide is upregulated in inflammatory conditions, including uremia; its antagonism has been shown to cause amelioration of inflammatory anemia in animal models.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
21864651-5	2012	Under high iron or inflammatory conditions hepcidin levels increase.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	43-51
21864651-6	2012	Hepcidin binds to the iron transport protein, ferroportin (FPN), promoting FPN internalization and degradation.	Iron	22-26	hepcidin antimicrobial peptide	Homo sapiens	0-8
21864651-11	2012	MAJOR CONCLUSIONS: TfR2 plays a key role in regulating iron homeostasis in the body.	Iron	55-59	transferrin receptor 2	Homo sapiens	19-23
22178646-1	2012	The present study examined the hypothesis that the iron exporter ferroportin (FPN1/SLC40A1) can also mediate cellular export of the essential trace element manganese, using Xenopus laevis oocytes expressing human FPN1.	Iron	51-55	solute carrier family 40 member 1	Homo sapiens	78-82
22178646-1	2012	The present study examined the hypothesis that the iron exporter ferroportin (FPN1/SLC40A1) can also mediate cellular export of the essential trace element manganese, using Xenopus laevis oocytes expressing human FPN1.	Iron	51-55	solute carrier family 40 (iron-regulated transporter), member 1 S homeolog	Xenopus laevis	83-90
22178646-1	2012	The present study examined the hypothesis that the iron exporter ferroportin (FPN1/SLC40A1) can also mediate cellular export of the essential trace element manganese, using Xenopus laevis oocytes expressing human FPN1.	Iron	51-55	solute carrier family 40 member 1	Homo sapiens	213-217
22178646-4	2012	FPN1-mediated Mn export was concentration dependent and could be partially cis-inhibited by 100muM Fe, Co, and Ni, but not by Rb.	Iron	99-101	solute carrier family 40 member 1	Homo sapiens	0-4
21647550-2	2012	On the other hand, oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD) and heme oxygenase-1 (HO-1), encoded by the HMOX1 gene and heme oxygenase-2 (HO-2), encoded by the HMOX2 gene are important markers of iron-related oxidative stress and its consequences.	Iron	253-257	heme oxygenase 1	Homo sapiens	162-167
21799206-1	2012	BACKGROUND: Hepcidin is a central regulator of iron homeostasis.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	12-20
21799206-2	2012	Increased hepcidin concentrations could cause iron-restricted erythropoiesis in chronic kidney disease (CKD)-associated anemia.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	10-18
21799206-11	2012	CONCLUSIONS: Serum hepcidin-25 levels were negatively associated with hemoglobin concentrations in non-dialysis CKD patients with sufficient iron stores.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	19-27
22281055-5	2012	We also demonstrated that Fpn1 expression was significantly affected by HIF-1alpha, implying that the gene encoding this iron efflux protein is hypoxia-inducible.	Iron	121-125	solute carrier family 40 member 1	Homo sapiens	26-30
22344440-4	2012	We report on the conversion of synthesis gas to C(2) through C(4) olefins with selectivity up to 60 weight percent, using catalysts that constitute iron nanoparticles (promoted by sulfur plus sodium) homogeneously dispersed on weakly interactive alpha-alumina or carbon nanofiber supports.	Iron	148-152	complement C2	Homo sapiens	48-52
22344440-4	2012	We report on the conversion of synthesis gas to C(2) through C(4) olefins with selectivity up to 60 weight percent, using catalysts that constitute iron nanoparticles (promoted by sulfur plus sodium) homogeneously dispersed on weakly interactive alpha-alumina or carbon nanofiber supports.	Iron	148-152	complement C4A (Rodgers blood group)	Homo sapiens	61-65
22144676-5	2012	Addition of BMPER peptide to primary human hepatocytes abolished the BMP2-dependent increase in hepcidin mRNA, whereas injection of Bmper peptide into mice resulted in reduced liver hepcidin and increased serum iron levels.	Iron	211-215	BMP binding endothelial regulator	Homo sapiens	132-137
22335577-11	2012	In spite of this, it is relevant that two complementary pathways that are regulatory of iron metabolism - the iron export (Fp/HAMP) and the iron import (TFRC/HFE) gene dyads - were embedded in the IRGS gene set and were associated with clinical outcome as well.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	126-130
22037960-3	2012	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme             in heme catabolism and results in the production of iron, carbon monoxide (CO),             and biliverdin IXalpha.	Iron	114-118	heme oxygenase 1	Homo sapiens	0-16
22037960-3	2012	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme             in heme catabolism and results in the production of iron, carbon monoxide (CO),             and biliverdin IXalpha.	Iron	114-118	heme oxygenase 1	Homo sapiens	18-22
22348459-11	2012	Iron repletion improved IL-4 measurements.	Iron	0-4	interleukin 4	Mus musculus	24-28
22706241-3	2012	Mitochondrial ferritin (FtMt), an iron-sequestering protein, is expressed in cell types characterized by high metabolic activity and oxygen consumption, including human retina, suggesting a role in protecting mitochondria from iron-dependent oxidative damage.	Iron	34-38	ferritin mitochondrial	Homo sapiens	24-28
22706241-3	2012	Mitochondrial ferritin (FtMt), an iron-sequestering protein, is expressed in cell types characterized by high metabolic activity and oxygen consumption, including human retina, suggesting a role in protecting mitochondria from iron-dependent oxidative damage.	Iron	227-231	ferritin mitochondrial	Homo sapiens	24-28
22706241-12	2012	CONCLUSIONS: Our findings suggest that the FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria.	Iron	152-156	ferritin mitochondrial	Homo sapiens	43-47
22094461-9	2012	All these suggest for the first time the following mechanism: mTOR/S6K down-regulation PLD2 overexpression PLD2/Fes association phosphatidic acid-led activation of Fes kinase granulocytic differentiation.	Iron	112-115	tortured	Mus musculus	62-70
22584997-0	2012	Mild iron overload in an African American man with SLC40A1 D270V.	Iron	5-9	solute carrier family 40 member 1	Homo sapiens	51-58
22584997-2	2012	Exome sequencing revealed heterozygosity for SLC40A1 D270V (exon 7, c.809A T), a mutation previously reported only in 1 black patient with iron overload who resided in the Republic of South Africa.	Iron	139-143	solute carrier family 40 member 1	Homo sapiens	45-52
22154351-5	2012	These three series represent promising starting points for lead optimization efforts aimed at the discovery of DMT1 blockers as iron overload therapeutics.	Iron	128-132	solute carrier family 11 member 2	Homo sapiens	111-115
23249638-3	2012	gamma-Glutamyltransferase (GGT), a novel source of           cellular production of oxidants in the presence of           iron and reduced glutathione (GSH), is also found on           platelets.	Iron	122-126	gamma-glutamyltransferase light chain family member 3	Homo sapiens	0-25
23249638-3	2012	gamma-Glutamyltransferase (GGT), a novel source of           cellular production of oxidants in the presence of           iron and reduced glutathione (GSH), is also found on           platelets.	Iron	122-126	gamma-glutamyltransferase light chain family member 3	Homo sapiens	27-30
22117533-7	2012	RESULTS: Data revealed (1) the noticeable LPO and glutathione (GSH) enzymatic system retinal and optic nerve activities; (2) the retinal expression and distribution of both the ADH3 and ALDH2; and (3) the co-localisation of iron/nicotine adenine dinucleotide phosphate (Fe/NADPH)-induced LPO, mainly in the outermost and innermost retinal strata, as compared to the rest of the retinal layers (p &lt; 0.001).	Iron	224-228	aldehyde dehydrogenase 2 family member	Rattus norvegicus	186-191
22117533-7	2012	RESULTS: Data revealed (1) the noticeable LPO and glutathione (GSH) enzymatic system retinal and optic nerve activities; (2) the retinal expression and distribution of both the ADH3 and ALDH2; and (3) the co-localisation of iron/nicotine adenine dinucleotide phosphate (Fe/NADPH)-induced LPO, mainly in the outermost and innermost retinal strata, as compared to the rest of the retinal layers (p &lt; 0.001).	Iron	270-272	aldehyde dehydrogenase 2 family member	Rattus norvegicus	186-191
23088733-7	2012	Hepcidin and hepcidin/ferritin ratios can be used as good markers of hemolytic anemia and iron overload as they have very high sensitivity (99.0 and 99.0%, respectively) and very high specificity (98.0 and 97.0%, respectively).	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
23088733-7	2012	Hepcidin and hepcidin/ferritin ratios can be used as good markers of hemolytic anemia and iron overload as they have very high sensitivity (99.0 and 99.0%, respectively) and very high specificity (98.0 and 97.0%, respectively).	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	13-21
23088733-9	2012	The use of hepcidin as an adjuvant therapy with iron chelators is important as it has a vital role in combating hemosidrosis.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	11-19
22121494-9	2012	Smad signaling pathway in the liver may therefore be involved in the regulation of hepcidin transcription and iron metabolism by alcohol.	Iron	110-114	SMAD family member 1	Mus musculus	0-4
22408404-4	2012	In addition to HFE gene, mutations in the genes that encode hemojuvelin (HJV), hepcidin (HAMP), transferrin receptor 2 (TFR2) and ferroportin (SLC40A1) have been associated with regulation of iron homeostasis and development of HH.	Iron	192-196	transferrin receptor 2	Homo sapiens	96-118
22408404-4	2012	In addition to HFE gene, mutations in the genes that encode hemojuvelin (HJV), hepcidin (HAMP), transferrin receptor 2 (TFR2) and ferroportin (SLC40A1) have been associated with regulation of iron homeostasis and development of HH.	Iron	192-196	transferrin receptor 2	Homo sapiens	120-124
22408404-4	2012	In addition to HFE gene, mutations in the genes that encode hemojuvelin (HJV), hepcidin (HAMP), transferrin receptor 2 (TFR2) and ferroportin (SLC40A1) have been associated with regulation of iron homeostasis and development of HH.	Iron	192-196	solute carrier family 40 member 1	Homo sapiens	143-150
22039296-7	2012	Kas-1 and Tsu-1 had different timing and magnitude of ferric reductase activity upon Fe withdrawal, and different categories of overrepresented Fe-regulated genes.	Iron	85-87	3-ketoacyl-acyl carrier protein synthase I	Arabidopsis thaliana	0-5
25063332-1	2012	BACKGROUND: There is evidence that interaction with biologically important metals, particularly copper and iron, contributes to the pathological aggregation and toxicity of the mutant huntingtin protein in HD.	Iron	107-111	huntingtin	Mus musculus	184-194
22619668-11	2012	In a longer perspective, lowering serum hepcidin levels may improve pathological iron homeostasis.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	40-48
23095372-5	2012	RESULTS: CD163-expressing macrophages, HO-1 and NADPH-p22 expression were located in areas surrounding tubules with iron deposits and filled with erythrocyte casts.	Iron	116-120	heme oxygenase 1	Homo sapiens	39-43
25762975-5	2012	Hepcidin degrades ferroportin and blocks the passage of iron from the intestinal cell to the plasma.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	0-8
25762975-9	2012	In contrast, inflammation and increased hepcidin associated with adiposity in overweight have been linked to both lower iron absorption and the decreased efficacy of iron- fortified foods.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	40-48
25762975-9	2012	In contrast, inflammation and increased hepcidin associated with adiposity in overweight have been linked to both lower iron absorption and the decreased efficacy of iron- fortified foods.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	40-48
21400189-3	2012	Hepcidin up-regulation in the setting of CKD, with subsequent increased serum levels, results in impaired iron absorption from the intestine and decreased iron release from body storage sites.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
21400189-3	2012	Hepcidin up-regulation in the setting of CKD, with subsequent increased serum levels, results in impaired iron absorption from the intestine and decreased iron release from body storage sites.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	0-8
22396654-5	2012	To better understand the regulation of iron homeostasis, we performed a TF-limited genetic screen for factors influencing ftn-1 gene expression.	Iron	39-43	Ferritin	Caenorhabditis elegans	122-127
22396654-8	2012	ftn-1 expression is induced by exposure to iron, and we found that hif-1 was required for this induction.	Iron	43-47	Ferritin	Caenorhabditis elegans	0-5
22396654-12	2012	We suggest that IIS/DAF-16 regulation of ftn-1 modulates a trade-off between growth and stress resistance, as elevated iron availability supports growth but also increases ROS production.	Iron	119-123	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	20-26
22396654-12	2012	We suggest that IIS/DAF-16 regulation of ftn-1 modulates a trade-off between growth and stress resistance, as elevated iron availability supports growth but also increases ROS production.	Iron	119-123	Ferritin	Caenorhabditis elegans	41-46
23110054-0	2012	Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	15-23
23049824-7	2012	Se-lactoferrin is a lactoferrin that we prepared that binds selenium instead of iron.	Iron	80-84	lactotransferrin	Rattus norvegicus	3-14
23049824-7	2012	Se-lactoferrin is a lactoferrin that we prepared that binds selenium instead of iron.	Iron	80-84	lactotransferrin	Rattus norvegicus	20-31
22723983-4	2012	We found iron and TGF-beta increased hepcidin mRNA expression or TGF-beta receptor kinase activity, respectively, which indicated that 2.2.15 cells responded appropriately to these substances.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	37-45
22666436-3	2012	We hypothesized that the increase of iron through a NF-kappaB-regulated 1B isoform of the divalent metal transporter-1 (1B/DMT1) might contribute to post-ischemic neuronal damage.	Iron	37-41	solute carrier family 11 member 2	Homo sapiens	123-127
22666436-5	2012	Either OGD or over-expression of 1B/(-)IRE DMT1 isoform significantly increased iron uptake, as detected by total reflection X-ray fluorescence, and iron-dependent cell death.	Iron	80-84	solute carrier family 11 member 2	Homo sapiens	43-47
22666436-5	2012	Either OGD or over-expression of 1B/(-)IRE DMT1 isoform significantly increased iron uptake, as detected by total reflection X-ray fluorescence, and iron-dependent cell death.	Iron	149-153	solute carrier family 11 member 2	Homo sapiens	43-47
22666436-6	2012	Iron chelation by deferoxamine treatment or (-)IRE DMT1 RNA silencing displayed significant neuroprotection against OGD which concomitantly decreased intracellular iron levels.	Iron	164-168	solute carrier family 11 member 2	Homo sapiens	51-55
22412990-6	2012	In addition, Abeta binds to Hb and other hemoproteins via the iron-containing heme moiety, thereby reducing Hb/heme/iron-induced cytotoxicity.	Iron	62-66	amyloid beta (A4) precursor protein	Mus musculus	13-18
22412990-6	2012	In addition, Abeta binds to Hb and other hemoproteins via the iron-containing heme moiety, thereby reducing Hb/heme/iron-induced cytotoxicity.	Iron	116-120	amyloid beta (A4) precursor protein	Mus musculus	13-18
22009536-0	2011	Wnt inhibitor screen reveals iron dependence of beta-catenin signaling in cancers.	Iron	29-33	catenin beta 1	Homo sapiens	48-60
21989655-2	2011	The reaction of the iron complex [Fe(CO)(4)(GaCp*)] with ZnMe(2) in presence of tetrahydrofurane (thf) leads to the dimeric compound [(CO)(4)Fe{mu(2)-Zn(thf)(2)}(2)Fe(CO)(4)] (1).	Iron	20-24	glutaminase	Homo sapiens	44-48
21987576-7	2011	Isa1 and Isa2 proteins are shown to bind iron in vivo, yet the Isa1-Isa2-bound iron was not needed as a donor for de novo assembly of the [2Fe-2S] cluster on the general Fe/S scaffold proteins Isu1-Isu2.	Iron	41-45	iron-sulfur cluster assembly 2	Homo sapiens	9-13
21987576-7	2011	Isa1 and Isa2 proteins are shown to bind iron in vivo, yet the Isa1-Isa2-bound iron was not needed as a donor for de novo assembly of the [2Fe-2S] cluster on the general Fe/S scaffold proteins Isu1-Isu2.	Iron	79-83	iron-sulfur cluster assembly 2	Homo sapiens	68-72
21907291-1	2011	DNA-binding protein from starved cells (Dps) is a member of ferritin-like proteins that exhibit properties of nonspecific DNA binding and iron oxidation and storage.	Iron	138-142	protein family HMM PF00816	Edwardsiella tarda	0-19
21862411-2	2011	Hepcidin deficiency underlies iron overload in HFE-hemochromatosis as well as in several other genetic iron excess disorders, such as hemojuvelin or hepcidin-related hemochromatosis and transferrin receptor 2-related hemochromatosis.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	0-8
21862411-4	2011	By contrast, genetically enhanced hepcidin production, as observed in matriptase-2 deficiency, generates iron-refractory iron deficiency anemia.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	34-42
22056558-1	2011	Carboxymethylation of equine heart cytochrome c (cytc) changes its tertiary structure by disrupting the heme-Fe-Met80 distal bond, such that carboxymethylated cytc (CM-cytc) displays myoglobin-like properties.	Iron	109-111	cytochrome c, somatic	Equus caballus	35-47
21894971-7	2011	The iron nanoparticles are interconnected and form a bicontinuous network, which provides a pathway for local electron transport through the insulating LiF phase.	Iron	4-8	LIF interleukin 6 family cytokine	Homo sapiens	152-155
21971825-1	2011	Hepcidin is an antimicrobial peptide hormone involved in the metabolism of iron, encoded for by the HAMP gene mainly in hepatocytes.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	0-8
21971825-1	2011	Hepcidin is an antimicrobial peptide hormone involved in the metabolism of iron, encoded for by the HAMP gene mainly in hepatocytes.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	100-104
21971825-4	2011	GATA- and its co-factor Friend of GATA (FOG) modulate the tissue-specific transcription of other genes involved in the metabolism of iron.	Iron	133-137	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	0-4
21917924-6	2011	CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of either CCC1 or YAP5 resulted in high iron sensitivity.	Iron	17-21	Yap5p	Saccharomyces cerevisiae S288C	89-93
21917924-6	2011	CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of either CCC1 or YAP5 resulted in high iron sensitivity.	Iron	111-115	Yap5p	Saccharomyces cerevisiae S288C	37-41
21917924-6	2011	CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of either CCC1 or YAP5 resulted in high iron sensitivity.	Iron	111-115	Yap5p	Saccharomyces cerevisiae S288C	89-93
21917924-9	2011	We conclude that the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters.	Iron	83-87	Yap5p	Saccharomyces cerevisiae S288C	21-25
21917924-9	2011	We conclude that the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters.	Iron	134-138	Yap5p	Saccharomyces cerevisiae S288C	21-25
21917924-9	2011	We conclude that the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters.	Iron	134-138	Yap5p	Saccharomyces cerevisiae S288C	21-25
21852364-1	2011	The Menkes copper ATPase (Atp7a) and metallothionein (Mt1a) are induced in the duodenum of iron-deficient rats, and serum and hepatic copper levels increase.	Iron	91-95	ATPase copper transporting alpha	Rattus norvegicus	26-31
21733041-3	2011	Hepcidin levels were related to iron homeostasis parameters and interleukin (IL)-6 levels.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
21733041-9	2011	Studies are needed to assess the contribution of hepcidin to iron homeostasis during the periparturition period.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	49-57
21603885-8	2011	Iron-enriched S. aureus PDF was obtained by adding FeCl(3) to the growth medium for E. coli BL21 (DE3) cells and adding FeCl(3) and catalase to all reagents used for purification.	Iron	0-4	peptide deformylase, mitochondrial	Homo sapiens	24-27
21706374-5	2011	Our data support that ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity, probably through its antioxidant properties independently of its function of iron metabolism.	Iron	183-187	ceruloplasmin	Mus musculus	22-35
22339912-7	2011	We can predict the occurrence of iron overload in transfusion dependent MDS patients by dynamic monitoring concentration of Hepcidin.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	124-132
22639604-0	2011	The Iron Assimilatory Protein, FEA1, from Chlamydomonas reinhardtii Facilitates Iron-Specific Metal Uptake in Yeast and Plants.	Iron	4-8	uncharacterized protein	Chlamydomonas reinhardtii	31-35
22639604-0	2011	The Iron Assimilatory Protein, FEA1, from Chlamydomonas reinhardtii Facilitates Iron-Specific Metal Uptake in Yeast and Plants.	Iron	80-84	uncharacterized protein	Chlamydomonas reinhardtii	31-35
22639604-1	2011	We demonstrate that the unique green algal iron assimilatory protein, FEA1, is able to complement the Arabidopsis iron-transporter mutant, irt1, as well as enhance iron accumulation in FEA1 expressing wild-type plants.	Iron	43-47	uncharacterized protein	Chlamydomonas reinhardtii	70-74
22639604-1	2011	We demonstrate that the unique green algal iron assimilatory protein, FEA1, is able to complement the Arabidopsis iron-transporter mutant, irt1, as well as enhance iron accumulation in FEA1 expressing wild-type plants.	Iron	43-47	uncharacterized protein	Chlamydomonas reinhardtii	185-189
22639604-1	2011	We demonstrate that the unique green algal iron assimilatory protein, FEA1, is able to complement the Arabidopsis iron-transporter mutant, irt1, as well as enhance iron accumulation in FEA1 expressing wild-type plants.	Iron	114-118	uncharacterized protein	Chlamydomonas reinhardtii	70-74
22639604-2	2011	Expression of the FEA1 protein reduced iron-deficient growth phenotypes when plants were grown under iron limiting conditions and enhanced iron accumulation up to fivefold relative to wild-type plants when grown in iron sufficient media.	Iron	39-43	uncharacterized protein	Chlamydomonas reinhardtii	18-22
22639604-2	2011	Expression of the FEA1 protein reduced iron-deficient growth phenotypes when plants were grown under iron limiting conditions and enhanced iron accumulation up to fivefold relative to wild-type plants when grown in iron sufficient media.	Iron	101-105	uncharacterized protein	Chlamydomonas reinhardtii	18-22
22639604-2	2011	Expression of the FEA1 protein reduced iron-deficient growth phenotypes when plants were grown under iron limiting conditions and enhanced iron accumulation up to fivefold relative to wild-type plants when grown in iron sufficient media.	Iron	101-105	uncharacterized protein	Chlamydomonas reinhardtii	18-22
22639604-2	2011	Expression of the FEA1 protein reduced iron-deficient growth phenotypes when plants were grown under iron limiting conditions and enhanced iron accumulation up to fivefold relative to wild-type plants when grown in iron sufficient media.	Iron	101-105	uncharacterized protein	Chlamydomonas reinhardtii	18-22
22639604-3	2011	Using yeast iron-uptake mutants, we demonstrate that the FEA1 protein specifically facilitates the uptake of the ferrous form of iron.	Iron	12-16	uncharacterized protein	Chlamydomonas reinhardtii	57-61
22639604-3	2011	Using yeast iron-uptake mutants, we demonstrate that the FEA1 protein specifically facilitates the uptake of the ferrous form of iron.	Iron	129-133	uncharacterized protein	Chlamydomonas reinhardtii	57-61
22639604-5	2011	These results indicate that the FEA1 protein is iron specific consistent with the observation the FEA1 protein is overexpressed in cadmium stressed algae presumably to facilitate iron uptake.	Iron	48-52	uncharacterized protein	Chlamydomonas reinhardtii	32-36
22639604-5	2011	These results indicate that the FEA1 protein is iron specific consistent with the observation the FEA1 protein is overexpressed in cadmium stressed algae presumably to facilitate iron uptake.	Iron	48-52	uncharacterized protein	Chlamydomonas reinhardtii	98-102
22639604-5	2011	These results indicate that the FEA1 protein is iron specific consistent with the observation the FEA1 protein is overexpressed in cadmium stressed algae presumably to facilitate iron uptake.	Iron	179-183	uncharacterized protein	Chlamydomonas reinhardtii	32-36
22639604-5	2011	These results indicate that the FEA1 protein is iron specific consistent with the observation the FEA1 protein is overexpressed in cadmium stressed algae presumably to facilitate iron uptake.	Iron	179-183	uncharacterized protein	Chlamydomonas reinhardtii	98-102
22639604-6	2011	We propose that the FEA1 iron assimilatory protein has ideal characteristics for the iron biofortification of crops and/or for facilitated iron uptake in plants when they are grown in low iron, high pH soils, or soils that may be contaminated with heavy metals.	Iron	25-29	uncharacterized protein	Chlamydomonas reinhardtii	20-24
22639604-6	2011	We propose that the FEA1 iron assimilatory protein has ideal characteristics for the iron biofortification of crops and/or for facilitated iron uptake in plants when they are grown in low iron, high pH soils, or soils that may be contaminated with heavy metals.	Iron	85-89	uncharacterized protein	Chlamydomonas reinhardtii	20-24
22639604-6	2011	We propose that the FEA1 iron assimilatory protein has ideal characteristics for the iron biofortification of crops and/or for facilitated iron uptake in plants when they are grown in low iron, high pH soils, or soils that may be contaminated with heavy metals.	Iron	85-89	uncharacterized protein	Chlamydomonas reinhardtii	20-24
22639604-6	2011	We propose that the FEA1 iron assimilatory protein has ideal characteristics for the iron biofortification of crops and/or for facilitated iron uptake in plants when they are grown in low iron, high pH soils, or soils that may be contaminated with heavy metals.	Iron	85-89	uncharacterized protein	Chlamydomonas reinhardtii	20-24
21873547-2	2011	Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption.	Iron	211-215	bone morphogenetic protein 1	Homo sapiens	13-39
21873547-2	2011	Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption.	Iron	211-215	bone morphogenetic protein 1	Homo sapiens	41-44
21873547-2	2011	Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption.	Iron	211-215	hemojuvelin BMP co-receptor	Homo sapiens	57-68
21873547-2	2011	Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption.	Iron	211-215	hemojuvelin BMP co-receptor	Homo sapiens	70-73
21873547-7	2011	Our results indicate that rs855791 is a TMPRSS6 functional variant and strengthen the idea that even a partial inability to modulate hepcidin influences iron parameters and, indirectly, erythropoiesis.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	133-141
21873546-1	2011	Hepcidin controls the levels and distribution of iron, an element whose availability can influence the outcome of infections.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
22090784-1	2011	Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/bilirubin and free iron.	Iron	126-130	heme oxygenase 1	Homo sapiens	0-16
21653899-2	2011	Here, we directly tested the hypothesis that Zip14 transports free zinc, iron, and other metal ions by using the Xenopus laevis oocyte heterologous expression system, and use of this approach also allowed us to characterize the functional properties of Zip14.	Iron	73-77	solute carrier family 39 (zinc transporter), member 14 L homeolog	Xenopus laevis	45-50
21939910-8	2011	The iron metabolism regulators, hepcidin and prohepcidin, are still under investigation in IBD.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	32-40
21360750-6	2011	ANX-SPIO produced T2* signal loss, reflecting iron content, that correlated highly with independent apoptosis markers; bound with high affinity to apoptotic myocytes by competition assay (Ki 69 nM); detected apoptosis in culture much earlier than did TUNEL stain; and revealed fibroblast resistance to apoptosis.	Iron	46-50	annexin A5	Homo sapiens	0-8
21360750-7	2011	With apoptosis in vivo, ANX-SPIO produced diffuse myocardial T2* signal loss that correlated with increased iron stain and caspase activity.	Iron	108-112	annexin A5	Homo sapiens	24-32
21807901-7	2011	Mzm1 may function primarily to stabilize Rip1 prior to inner membrane (IM) insertion or alternatively to aid in the presentation of Rip1 to the inner membrane translocation complex for extrusion of the folded domain containing the iron-sulfur center.	Iron	231-235	Mzm1p	Saccharomyces cerevisiae S288C	0-4
21795716-3	2011	Notably, nigral dopaminergic neurons are enriched in iron, the uptake of which is facilitated by the divalent metal ion transporter DMT1.	Iron	53-57	solute carrier family 11 member 2	Homo sapiens	132-136
21795716-5	2011	We found that DMT1 overexpression dramatically enhances Fe(2+) uptake, which concomitantly promotes cell death.	Iron	56-58	solute carrier family 11 member 2	Homo sapiens	14-18
21914223-8	2011	Relative biological effectiveness (RBE) at 10% survival for U-CH1-N was about 2.45 for 70 keV/mum carbon and 3.86 for 200 keV/mum iron ions.	Iron	130-134	SUN domain containing ossification factor	Homo sapiens	62-65
21980225-6	2011	Iron attenuated the diabetes induced down regulation of peroxisome proliferator-activated receptor-alpha mRNA.	Iron	0-4	peroxisome proliferator activated receptor alpha	Homo sapiens	56-104
21785125-0	2011	Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	120-128
21785125-1	2011	BACKGROUND: Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin results in iron overload or iron deficiency and anaemia.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	12-20
21785125-1	2011	BACKGROUND: Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin results in iron overload or iron deficiency and anaemia.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	92-100
21785125-1	2011	BACKGROUND: Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin results in iron overload or iron deficiency and anaemia.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	12-20
21785125-1	2011	BACKGROUND: Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin results in iron overload or iron deficiency and anaemia.	Iron	112-116	hepcidin antimicrobial peptide	Homo sapiens	92-100
21785125-6	2011	CONCLUSIONS: The results suggest a mutual control of serum hepcidin and ferritin concentrations, a mechanism relevant to the pathophysiology of HFE haemochromatosis, and demonstrate that the HFE rs1800562 C282Y variant exerts a direct pleiotropic effect on the iron parameters, in part independent of hepcidin.	Iron	261-265	hepcidin antimicrobial peptide	Homo sapiens	59-67
21243526-10	2011	These results clearly showed that H43/Fea1 expression is regulated by high-CO(2) signal independently via the HCRE that is located distantly from Fe-deficient-signal responsive element, indicating that H43/Fea1 is a multi-signal-regulated gene.	Iron	38-40	uncharacterized protein	Chlamydomonas reinhardtii	206-210
21834952-8	2011	Urinary hepcidin showed significant positive correlation with hemoglobin, mean corpuscular volume, hematocrit value, serum iron and ferritin and transferrin saturation.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	8-16
21834952-9	2011	In contrary, it showed significant negative correlation with serum transferrin and total iron binding capacity.Urinary hepcidin at cutoff point &lt;=0.94 nmol/mmol Cr could Predict ID stage-1 with sensitivity 88% and specificity 88%.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	119-127
21834952-12	2011	CONCLUSIONS: We can conclude that detection of urinary hepcidin-25 level was a simple and non invasive test and could predict iron deficiency very early, before appearance of hematological affections.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	55-63
21816077-2	2011	Recently, interest has focused on hepcidin, a regulator of iron homeostasis, as a unique renal biomarker.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	34-42
20602178-0	2011	Iron fortification of banana by the expression of soybean ferritin.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	58-66
21762639-1	2011	BACKGROUND: Hepcidin regulates iron homeostasis by blocking iron absorption from the gut and iron release from macrophage and hepatocyte stores.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	12-20
21762639-1	2011	BACKGROUND: Hepcidin regulates iron homeostasis by blocking iron absorption from the gut and iron release from macrophage and hepatocyte stores.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	12-20
21762639-1	2011	BACKGROUND: Hepcidin regulates iron homeostasis by blocking iron absorption from the gut and iron release from macrophage and hepatocyte stores.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	12-20
21677632-2	2011	To prevent iron deficiency and overload, iron balance is regulated by the hormone hepcidin.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	82-90
21677632-3	2011	Hepcidin levels increase in response to iron sufficiency, decreasing intestinal iron absorption and inhibiting release of iron from stores and macrophages.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
21677632-3	2011	Hepcidin levels increase in response to iron sufficiency, decreasing intestinal iron absorption and inhibiting release of iron from stores and macrophages.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
21677632-3	2011	Hepcidin levels increase in response to iron sufficiency, decreasing intestinal iron absorption and inhibiting release of iron from stores and macrophages.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
21677632-4	2011	Iron deficiency lowers hepcidin, leading to enhanced iron absorption and mobilization of iron from stores.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	23-31
21677632-4	2011	Iron deficiency lowers hepcidin, leading to enhanced iron absorption and mobilization of iron from stores.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	23-31
21677632-7	2011	Elevated hepcidin contributes to the dysregulation of iron homeostasis in CKD.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	9-17
21677632-8	2011	In patients with CKD, although parenteral iron in CKD can bypass some of the iron-blocking effects of hepcidin, free iron and iron stores increase, anemia is only partially corrected, and ESA dose requirements remain significantly higher than physiological replacement.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	102-110
21677632-9	2011	Agents that lower hepcidin or inhibit its actions may be effective strategies to restore normal iron homeostasis, and overcome anemia of chronic kidney disease.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	18-26
21733088-7	2011	After iron depletion, hepcidin levels decreased to normal values in all patients.	Iron	6-10	hepcidin antimicrobial peptide	Homo sapiens	22-30
21733088-8	2011	At baseline, a significant response of hepcidin to iron challenge was observed only in the subgroup with lower basal hepcidin concentration (P = 0.007).	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	39-47
21733088-8	2011	At baseline, a significant response of hepcidin to iron challenge was observed only in the subgroup with lower basal hepcidin concentration (P = 0.007).	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	117-125
21733088-9	2011	In iron-depleted patients, urinary hepcidin significantly increased after oral iron test (P = 0 .006).	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	35-43
21733088-9	2011	In iron-depleted patients, urinary hepcidin significantly increased after oral iron test (P = 0 .006).	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	35-43
21733088-10	2011	CONCLUSIONS: Ours findings suggest that in DIOS, the progression of iron accumulation is counteracted by the increase in hepcidin production and progressive reduction of iron absorption, explaining why these patients develop a mild-moderate iron overload that tends to a plateau.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	121-129
21245128-8	2011	CONCLUSION: Serum levels of both hepcidin and TNF-alpha are independently associated with arterial stiffness in MHD patients, suggesting that microinflammation and iron metabolism might affect the integrity of arterial walls.	Iron	164-168	hepcidin antimicrobial peptide	Homo sapiens	33-41
21622652-3	2011	Hepcidin is positively regulated by iron via the bone morphogenetic protein (BMP)-SMAD signaling pathway.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
21622652-3	2011	Hepcidin is positively regulated by iron via the bone morphogenetic protein (BMP)-SMAD signaling pathway.	Iron	36-40	bone morphogenetic protein 1	Homo sapiens	49-75
21622652-3	2011	Hepcidin is positively regulated by iron via the bone morphogenetic protein (BMP)-SMAD signaling pathway.	Iron	36-40	bone morphogenetic protein 1	Homo sapiens	77-80
21622652-8	2011	Our results indicate that BMP6 and iron not only induce hepcidin expression but also induce TMPRSS6, a negative regulator of hepcidin expression.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	56-64
21622652-8	2011	Our results indicate that BMP6 and iron not only induce hepcidin expression but also induce TMPRSS6, a negative regulator of hepcidin expression.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	125-133
21622652-9	2011	Modulation of TMPRSS6 expression could serve as a negative feedback inhibitor to avoid excessive hepcidin increases by iron to help maintain tight homeostatic balance of systemic iron levels.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	97-105
21622652-9	2011	Modulation of TMPRSS6 expression could serve as a negative feedback inhibitor to avoid excessive hepcidin increases by iron to help maintain tight homeostatic balance of systemic iron levels.	Iron	179-183	hepcidin antimicrobial peptide	Homo sapiens	97-105
21513996-7	2011	CONCLUSION: All of these data demonstrated that the higher hepcidin levels in diabetic patients may be due to those higher ferritin and IL-6 levels, the elevated hepcidin might have adaptive value through down-regulated iron absorb and play an important role in pathogenesis of Type 2 DM.	Iron	220-224	hepcidin antimicrobial peptide	Homo sapiens	59-67
21513996-7	2011	CONCLUSION: All of these data demonstrated that the higher hepcidin levels in diabetic patients may be due to those higher ferritin and IL-6 levels, the elevated hepcidin might have adaptive value through down-regulated iron absorb and play an important role in pathogenesis of Type 2 DM.	Iron	220-224	hepcidin antimicrobial peptide	Homo sapiens	162-170
21507054-2	2011	The PDF of Mycobacterium tuberculosis H37Rv (MtbPDF), overexpressed and purified from Escherichia coli, was characterized as an iron-containing enzyme with stability towards H(2) O(2) and moderate thermostability.	Iron	128-132	peptide deformylase, mitochondrial	Homo sapiens	4-7
21271785-0	2011	Persistence of gamma-H2AX and 53BP1 foci in proliferating and non-proliferating human mammary epithelial cells after exposure to gamma-rays or iron ions.	Iron	143-147	tumor protein p53 binding protein 1	Homo sapiens	30-35
21839232-3	2011	Furthermore, we determined serum prohepcidin, a precursor of hepcidin, the main hormone implicated in iron metabolism.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	36-44
21877597-4	2011	Hepcidin maintains the iron homeostasis in the organism.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	0-8
21418708-0	2011	Iron regulates the uptake of ascorbic acid and the expression of sodium-dependent vitamin C transporter 1 (SVCT1) in human intestinal Caco-2 cells.	Iron	0-4	solute carrier family 23 member 1	Homo sapiens	65-105
21418708-0	2011	Iron regulates the uptake of ascorbic acid and the expression of sodium-dependent vitamin C transporter 1 (SVCT1) in human intestinal Caco-2 cells.	Iron	0-4	solute carrier family 23 member 1	Homo sapiens	107-112
21418708-4	2011	SVCT1 is involved in the cellular uptake of ascorbic acid and is therefore a candidate for playing a role in the regulation of Fe utilisation.	Iron	127-129	solute carrier family 23 member 1	Homo sapiens	0-5
21418708-7	2011	Furthermore, when cells deficient in ascorbic acid were exposed to Fe, SVCT1 expression increased significantly (23 7 %).	Iron	67-69	solute carrier family 23 member 1	Homo sapiens	71-76
21514188-1	2011	Based on a microarray study, which demonstrated the upregulation of Sp6 transcriptional factor in iron deficient rat duodenum, we reasoned that SP6 could regulate iron absorption by controlling the expression of iron absorption genes (Collins,2006).	Iron	98-102	Sp6 transcription factor	Rattus norvegicus	68-71
21514188-1	2011	Based on a microarray study, which demonstrated the upregulation of Sp6 transcriptional factor in iron deficient rat duodenum, we reasoned that SP6 could regulate iron absorption by controlling the expression of iron absorption genes (Collins,2006).	Iron	98-102	Sp6 transcription factor	Rattus norvegicus	144-147
21514188-1	2011	Based on a microarray study, which demonstrated the upregulation of Sp6 transcriptional factor in iron deficient rat duodenum, we reasoned that SP6 could regulate iron absorption by controlling the expression of iron absorption genes (Collins,2006).	Iron	163-167	Sp6 transcription factor	Rattus norvegicus	144-147
21514188-1	2011	Based on a microarray study, which demonstrated the upregulation of Sp6 transcriptional factor in iron deficient rat duodenum, we reasoned that SP6 could regulate iron absorption by controlling the expression of iron absorption genes (Collins,2006).	Iron	163-167	Sp6 transcription factor	Rattus norvegicus	144-147
21514188-4	2011	We propose that other Sp6 orthologues may be involved in the genetic response to increase iron absorption, possibly in co-operation with hypoxia inducible factor 2 alpha (HIF-2alpha)-a newly discovered regulator of iron absorption.	Iron	90-94	endothelial PAS domain protein 1	Mus musculus	137-169
21514188-4	2011	We propose that other Sp6 orthologues may be involved in the genetic response to increase iron absorption, possibly in co-operation with hypoxia inducible factor 2 alpha (HIF-2alpha)-a newly discovered regulator of iron absorption.	Iron	215-219	endothelial PAS domain protein 1	Mus musculus	137-169
21514188-4	2011	We propose that other Sp6 orthologues may be involved in the genetic response to increase iron absorption, possibly in co-operation with hypoxia inducible factor 2 alpha (HIF-2alpha)-a newly discovered regulator of iron absorption.	Iron	215-219	endothelial PAS domain protein 1	Mus musculus	171-181
21315474-6	2011	While confirming that the CYP82C4 transcript accumulates in Fe-deficient Arabidopsis seedlings, with circadian fluctuations in a light-dependent way, we also demonstrate that such accumulation is suppressed under Fe excess.	Iron	213-215	cytochrome P450, family 82, subfamily C, polypeptide 4	Arabidopsis thaliana	26-33
21315474-8	2011	We propose that CYP82C4 is involved in the early Fe deficiency response, possibly through an IDE1-like mediated pathway.	Iron	49-51	cytochrome P450, family 82, subfamily C, polypeptide 4	Arabidopsis thaliana	16-23
21419768-7	2011	Fpn was rapidly induced under conditions of low iron, which required the transcription factor HIF-2alpha.	Iron	48-52	endothelial PAS domain protein 1	Mus musculus	94-104
21419768-8	2011	Targeted disruption of HIF-2alpha in the intestine inhibited Fpn induction in mice with low iron, through loss of transcriptional activation.	Iron	92-96	endothelial PAS domain protein 1	Mus musculus	23-33
21419768-9	2011	Analysis of the Fpn promoter and in vivo chromatin immunoprecipitation assays demonstrated that HIF-2alpha directly binds to the Fpn promoter and induces its expression, indicating a mechanism of transcriptional regulation of Fpn following changes in systemic levels of iron.	Iron	270-274	endothelial PAS domain protein 1	Mus musculus	96-106
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	202-204	hepcidin antimicrobial peptide	Homo sapiens	60-68
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	202-204	hepcidin antimicrobial peptide	Homo sapiens	94-102
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	202-204	hepcidin antimicrobial peptide	Homo sapiens	94-102
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	220-224	hepcidin antimicrobial peptide	Homo sapiens	60-68
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	220-224	hepcidin antimicrobial peptide	Homo sapiens	94-102
21438013-5	2011	Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1.	Iron	220-224	hepcidin antimicrobial peptide	Homo sapiens	94-102
21438013-7	2011	In conclusion, our results demonstrated that hepcidin controlled iron uptake and release by regulating expression of iron transport proteins.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	45-53
21438013-7	2011	In conclusion, our results demonstrated that hepcidin controlled iron uptake and release by regulating expression of iron transport proteins.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	45-53
21426349-0	2011	AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced alpha-synuclein oligomers.	Iron	71-75	synuclein alpha	Homo sapiens	84-99
21382684-2	2011	In this investigation, the MEEKC technique was applied for estimation of n-octanol-water partition coefficient (logP(oct)) of a series of antiproliferative complexes of gallium(III) and iron(III) with (4)N-substituted alpha-N-heterocyclic thiosemicarbazones.	Iron	186-190	plexin A2	Homo sapiens	75-78
21382684-5	2011	Extension of the logP(oct) programs by adding DeltalogP(oct) data resulted in good lipophilicity predictions for the complexes of gallium(III) and iron(III) included in one regression set.	Iron	147-151	plexin A2	Homo sapiens	22-25
21382684-5	2011	Extension of the logP(oct) programs by adding DeltalogP(oct) data resulted in good lipophilicity predictions for the complexes of gallium(III) and iron(III) included in one regression set.	Iron	147-151	plexin A2	Homo sapiens	46-60
20401695-1	2011	Stearoyl-CoA desaturase (SCD) is an iron-containing enzyme involving in the biosynthesis of monounsaturated fatty acids (MUFA) in mammary gland and adipose tissue, while decorin (DCN) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain, contributing multifunctionally to matrix assembly, modulation of the activity of growth factors and cell migration and proliferation.	Iron	36-40	stearoyl-CoA desaturase	Capra hircus	0-23
20401695-1	2011	Stearoyl-CoA desaturase (SCD) is an iron-containing enzyme involving in the biosynthesis of monounsaturated fatty acids (MUFA) in mammary gland and adipose tissue, while decorin (DCN) consists of a protein core and a single dermatan or chondroitin sulfate glycosaminoglycan chain, contributing multifunctionally to matrix assembly, modulation of the activity of growth factors and cell migration and proliferation.	Iron	36-40	stearoyl-CoA desaturase	Capra hircus	25-28
21737992-0	2011	[Signaling in iron metabolism via transferrin receptor 2: significance in erythropoiesis].	Iron	14-18	transferrin receptor 2	Homo sapiens	34-56
21815478-2	2011	The reticulocyte hemoglobin equivalent (RET-He) is an indirect measure of the functional iron available for the erythropoiesis over the previous 2-3 days.	Iron	89-93	ret proto-oncogene	Homo sapiens	40-43
21815478-6	2011	Of 26 patients receiving post-PABD iron replacement, 8 who had already showed low RET-He levels at PABD developed statistically significant reduction in hemoglobin levels after PABD despite adequate iron replacement, indicating that the 8 patients had iron deficiency prior to PABD.	Iron	35-39	ret proto-oncogene	Homo sapiens	82-85
19913089-6	2011	Pb transport displayed properties that were associated with iron response element (IRE) positive isoform of DMT1.	Iron	60-64	solute carrier family 11 member 2	Homo sapiens	108-112
21315066-2	2011	This study presents data related to Hp phenotypes and ceruloplasmin ferroxidase activity in relation to iron store markers in patients with beta-thalassemia major.	Iron	104-108	ceruloplasmin	Homo sapiens	54-79
21333642-0	2011	Hepcidin: a novel peptide hormone regulating iron metabolism.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
21333642-1	2011	BACKGROUND: Hepcidin is a low-molecular weight hepatic peptide regulating iron homeostasis.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	12-20
21333642-2	2011	Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the internalization and degradation of, ferroportin, the exclusive iron exporter in iron-transporting cells.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
21333642-2	2011	Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the internalization and degradation of, ferroportin, the exclusive iron exporter in iron-transporting cells.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	0-8
21333642-2	2011	Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the internalization and degradation of, ferroportin, the exclusive iron exporter in iron-transporting cells.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	0-8
21333642-6	2011	RESULT: Hepcidin regulates iron uptake constantly on a daily basis, to maintain sufficient iron stores for erythropoiesis.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	8-16
21333642-6	2011	RESULT: Hepcidin regulates iron uptake constantly on a daily basis, to maintain sufficient iron stores for erythropoiesis.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	8-16
21333642-7	2011	Hepcidin, by its iron regulatory action on iron metabolism may be expected to have an important role in immune regulation, inflammatory diseases and malignancies.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	0-8
21333642-7	2011	Hepcidin, by its iron regulatory action on iron metabolism may be expected to have an important role in immune regulation, inflammatory diseases and malignancies.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
21333642-9	2011	CONCLUSION: Hepcidin analysis may prove to be a novel tool for differential diagnosis and monitoring of disorders of iron metabolism, and establishment of therapeutic measures in various disease conditions like hereditary hemochromatosis, anemia associated with chronic kidney disease, rheumatoid arthritis and cancers.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	12-20
21548921-1	2011	BACKGROUND: NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2), containing one iron sulfur cluster ([2Fe-2S] binuclear cluster N1a), is one of the core nuclear-encoded subunits existing in human mitochondrial complex I.	Iron	84-88	NADH:ubiquinone oxidoreductase core subunit V2	Homo sapiens	60-66
21371898-7	2011	AtMfl1 gene expression is dependent on Fe supply: AtMfl1 transcript strongly accumulates under Fe excess, moderately under Fe sufficiency and weakly under Fe deficiency.	Iron	39-41	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-6
21371898-7	2011	AtMfl1 gene expression is dependent on Fe supply: AtMfl1 transcript strongly accumulates under Fe excess, moderately under Fe sufficiency and weakly under Fe deficiency.	Iron	39-41	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	50-56
21371898-7	2011	AtMfl1 gene expression is dependent on Fe supply: AtMfl1 transcript strongly accumulates under Fe excess, moderately under Fe sufficiency and weakly under Fe deficiency.	Iron	95-97	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-6
21371898-7	2011	AtMfl1 gene expression is dependent on Fe supply: AtMfl1 transcript strongly accumulates under Fe excess, moderately under Fe sufficiency and weakly under Fe deficiency.	Iron	95-97	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	50-56
21371898-7	2011	AtMfl1 gene expression is dependent on Fe supply: AtMfl1 transcript strongly accumulates under Fe excess, moderately under Fe sufficiency and weakly under Fe deficiency.	Iron	95-97	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-6
21371898-7	2011	AtMfl1 gene expression is dependent on Fe supply: AtMfl1 transcript strongly accumulates under Fe excess, moderately under Fe sufficiency and weakly under Fe deficiency.	Iron	95-97	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	50-56
21371898-9	2011	When grown under conditions of Fe excess, atmfl1-1 and atmfl1-2 mutants (seedlings, rosette leaves) contain less total Fe than wt and also reduced expression of the iron storage ferritin AtFer1.	Iron	31-33	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	42-63
21371898-9	2011	When grown under conditions of Fe excess, atmfl1-1 and atmfl1-2 mutants (seedlings, rosette leaves) contain less total Fe than wt and also reduced expression of the iron storage ferritin AtFer1.	Iron	119-121	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	42-63
21371898-9	2011	When grown under conditions of Fe excess, atmfl1-1 and atmfl1-2 mutants (seedlings, rosette leaves) contain less total Fe than wt and also reduced expression of the iron storage ferritin AtFer1.	Iron	165-169	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	42-63
21371898-10	2011	Taken together, these results suggest that Arabidopsis mitoferrinlike gene AtMfl1 is involved in Fe transport into chloroplasts, under different conditions of Fe supply and that suppression of its expression alters plant Fe accumulation in various developmental stages.	Iron	97-99	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	75-81
21371898-10	2011	Taken together, these results suggest that Arabidopsis mitoferrinlike gene AtMfl1 is involved in Fe transport into chloroplasts, under different conditions of Fe supply and that suppression of its expression alters plant Fe accumulation in various developmental stages.	Iron	159-161	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	75-81
21371898-10	2011	Taken together, these results suggest that Arabidopsis mitoferrinlike gene AtMfl1 is involved in Fe transport into chloroplasts, under different conditions of Fe supply and that suppression of its expression alters plant Fe accumulation in various developmental stages.	Iron	159-161	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	75-81
21276595-2	2011	SLC11A2 gene encodes the divalent metal transport 1 (DMT1) mediating iron transport in cerebral endosomal compartments.	Iron	69-73	solute carrier family 11 member 2	Homo sapiens	0-7
21276595-2	2011	SLC11A2 gene encodes the divalent metal transport 1 (DMT1) mediating iron transport in cerebral endosomal compartments.	Iron	69-73	solute carrier family 11 member 2	Homo sapiens	25-51
21276595-2	2011	SLC11A2 gene encodes the divalent metal transport 1 (DMT1) mediating iron transport in cerebral endosomal compartments.	Iron	69-73	solute carrier family 11 member 2	Homo sapiens	53-57
21361388-0	2011	Biophysical investigation of the iron in Aft1-1(up) and Gal-YAH1 Saccharomyces cerevisiae.	Iron	33-37	adrenodoxin	Saccharomyces cerevisiae S288C	60-64
21361388-5	2011	Ferredoxin Yah1p is involved in Fe/S cluster assembly, and Aft1p-targeted iron regulon genes are also upregulated in Yah1p-depleted cells.	Iron	74-78	adrenodoxin	Saccharomyces cerevisiae S288C	117-122
21361388-6	2011	In this study Mossbauer, EPR, and UV-vis spectroscopies were used to characterize the Fe distribution in Aft1-1(up) and Yah1p-depleted cells.	Iron	86-88	adrenodoxin	Saccharomyces cerevisiae S288C	120-125
21229381-0	2011	Ferrous iron is found in mesenteric lymph bound to TIMP-2 following hemorrhage/resuscitation.	Iron	0-12	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	51-57
21229381-5	2011	Utilizing immuno-spin trapping in protein fractions that were rich in iron, we tentatively indentified protein carrier(s) of ferrous iron by MALDI-TOF MS. One of the identified proteins was the metalloproteinase (MMP) inhibitor, TIMP-2.	Iron	133-137	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	229-235
21332711-0	2011	Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	16-24
21332711-1	2011	Hepcidin is a major regulator of iron metabolism.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	bone morphogenetic protein 6	Mus musculus	71-99
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	bone morphogenetic protein 6	Mus musculus	101-105
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	bone morphogenetic protein 6	Mus musculus	71-99
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	bone morphogenetic protein 6	Mus musculus	101-105
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	bone morphogenetic protein 6	Mus musculus	71-99
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	bone morphogenetic protein 6	Mus musculus	101-105
20868446-0	2011	Serum hepcidin-25 may replace the ferritin index in the Thomas plot in assessing iron status in anemic patients.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	6-14
20868446-10	2011	The hepcidin-25 plot and the ferritin index plot showed a good correspondence in the differentiation of iron states in patients with anemia.	Iron	104-108	hepcidin antimicrobial peptide	Homo sapiens	4-12
21364282-0	2011	The liver-specific microRNA miR-122 controls  systemic iron homeostasis in mice.	Iron	55-59	microRNA 122	Mus musculus	28-35
21364282-2	2011	Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels.	Iron	114-118	microRNA 122	Mus musculus	46-53
21364282-3	2011	Efficient and specific depletion of miR-122 by injection of a locked-nucleic-acid-modified (LNA-modified) anti-miR into WT mice caused systemic iron deficiency, characterized by reduced plasma and liver iron levels, mildly impaired hematopoiesis, and increased extramedullary erythropoiesis in the spleen.	Iron	144-148	microRNA 122	Mus musculus	36-43
21364282-4	2011	Moreover, miR-122 inhibition increased the amount of mRNA transcribed by genes that control systemic iron levels, such as hemochromatosis (Hfe), hemojuvelin (Hjv), bone morphogenetic protein receptor type 1A (Bmpr1a), and Hamp.	Iron	101-105	microRNA 122	Mus musculus	10-17
21186144-4	2011	However, hepcidin is negatively correlated with ESA needs and hepcidin expression is influenced by other factors as degree of renal insufficiency, iron pool, treatments (iron IV and ESA).	Iron	147-151	hepcidin antimicrobial peptide	Homo sapiens	62-70
21186144-4	2011	However, hepcidin is negatively correlated with ESA needs and hepcidin expression is influenced by other factors as degree of renal insufficiency, iron pool, treatments (iron IV and ESA).	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	62-70
21343424-0	2011	The chloroplast permease PIC1 regulates plant growth and development by directing homeostasis and transport of iron.	Iron	111-115	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	25-29
21343424-1	2011	The membrane-spanning protein PIC1 (for permease in chloroplasts 1) in Arabidopsis (Arabidopsis thaliana) was previously described to mediate iron transport across the inner envelope membrane of chloroplasts.	Iron	142-146	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	30-34
21343424-1	2011	The membrane-spanning protein PIC1 (for permease in chloroplasts 1) in Arabidopsis (Arabidopsis thaliana) was previously described to mediate iron transport across the inner envelope membrane of chloroplasts.	Iron	142-146	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	40-66
21343424-3	2011	In addition, plants lacking PIC1 showed a striking increase in chloroplast ferritin clusters, which function in protection from oxidative stress by sequestering highly reactive free iron in their spherical protein shell.	Iron	182-186	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	28-32
21343424-5	2011	PIC1ox plants suffered from oxidative stress and leaf chlorosis, most likely originating from iron overload in chloroplasts.	Iron	94-98	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	0-4
21343424-7	2011	As a result of PIC1 protein increase in the inner envelope membrane of plastids, flower tissue showed elevated levels of iron, while the content of other transition metals (copper, zinc, manganese) remained unchanged.	Iron	121-125	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	15-19
21343424-8	2011	Seeds, however, specifically revealed iron deficiency, suggesting that PIC1 overexpression sequestered iron in flower plastids, thereby becoming unavailable for seed iron loading.	Iron	38-42	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	71-75
21343424-8	2011	Seeds, however, specifically revealed iron deficiency, suggesting that PIC1 overexpression sequestered iron in flower plastids, thereby becoming unavailable for seed iron loading.	Iron	103-107	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	71-75
21343424-10	2011	Thus, PIC1 function in plastid iron transport is closely linked to ferritin and plastid iron homeostasis.	Iron	31-35	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	6-10
21343424-10	2011	Thus, PIC1 function in plastid iron transport is closely linked to ferritin and plastid iron homeostasis.	Iron	88-92	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	6-10
21343424-11	2011	In consequence, PIC1 is crucial for balancing plant iron metabolism in general, thereby regulating plant growth and in particular fruit development.	Iron	52-56	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	16-20
21149632-10	2011	The strong correlation between serum ferritin and hepcidin at each point during the study indicates that iron itself or the kinetics of iron use in response to hypoxia may signal hepcidin down-regulation.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	50-58
21149632-10	2011	The strong correlation between serum ferritin and hepcidin at each point during the study indicates that iron itself or the kinetics of iron use in response to hypoxia may signal hepcidin down-regulation.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	179-187
21149632-10	2011	The strong correlation between serum ferritin and hepcidin at each point during the study indicates that iron itself or the kinetics of iron use in response to hypoxia may signal hepcidin down-regulation.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	50-58
21149632-10	2011	The strong correlation between serum ferritin and hepcidin at each point during the study indicates that iron itself or the kinetics of iron use in response to hypoxia may signal hepcidin down-regulation.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	179-187
21356359-1	2011	Bone morphogenetic protein-6 (BMP-6) suppresses inflammatory genes in renal proximal tubular cells and regulates iron metabolism by inducing hepcidin.	Iron	113-117	bone morphogenetic protein 6	Mus musculus	0-28
21356359-1	2011	Bone morphogenetic protein-6 (BMP-6) suppresses inflammatory genes in renal proximal tubular cells and regulates iron metabolism by inducing hepcidin.	Iron	113-117	bone morphogenetic protein 6	Mus musculus	30-35
21356359-9	2011	The obstructed kidneys of BMP-6 null mice showed 2.2-fold more iron deposition, in association with 3.3-fold higher expression of the oxidative stress marker HO-1.	Iron	63-67	bone morphogenetic protein 6	Mus musculus	26-31
21183736-0	2011	Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations.	Iron	30-34	C-C motif chemokine ligand 2	Homo sapiens	50-55
21183736-1	2011	OBJECTIVE: Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	42-50
21183736-3	2011	METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	82-90
21183736-3	2011	METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler.	Iron	37-41	C-C motif chemokine ligand 2	Homo sapiens	102-142
21183736-3	2011	METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler.	Iron	346-350	hepcidin antimicrobial peptide	Homo sapiens	82-90
21183736-4	2011	In monocytes of healthy subjects (n=7), iron and hepcidin increased the mRNA levels and release of MCP-1, but not of interleukin-6.	Iron	40-44	C-C motif chemokine ligand 2	Homo sapiens	99-104
21183736-6	2011	CONCLUSIONS: Hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in high-risk individuals with metabolic alterations.	Iron	37-41	C-C motif chemokine ligand 2	Homo sapiens	57-62
21209031-0	2011	Role of decreased circulating hepcidin concentrations in the iron excess of women with the polycystic ovary syndrome.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	30-38
21209031-1	2011	CONTEXT: Hepcidin inhibits the intestinal absorption of iron and its deficiency causes juvenile hemochromatosis.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	9-17
21209031-2	2011	OBJECTIVE: The objective of the investigation was to study the involvement of hepcidin in the iron overload of patients with polycystic ovary syndrome (PCOS).	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	78-86
21209031-9	2011	Patients with PCOS presenting with chronic oligoamenorrhea (an iron sparing mechanism) showed a paradoxical decrease in serum hepcidin levels and an increase in ferritin to hepcidin molar ratios compared with the patients who had regular anovulatory menstrual cycles and with the controls.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	126-134
21209031-9	2011	Patients with PCOS presenting with chronic oligoamenorrhea (an iron sparing mechanism) showed a paradoxical decrease in serum hepcidin levels and an increase in ferritin to hepcidin molar ratios compared with the patients who had regular anovulatory menstrual cycles and with the controls.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	173-181
21209031-12	2011	CONCLUSIONS: Patients with PCOS had reduced serum hepcidin concentrations that might contribute to their iron overload by favoring the intestinal absorption of iron.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	50-58
21209031-12	2011	CONCLUSIONS: Patients with PCOS had reduced serum hepcidin concentrations that might contribute to their iron overload by favoring the intestinal absorption of iron.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	50-58
21373260-6	2011	Moreover, hepcidin controls ferroportin and plays a central role in the iron metabolism.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	10-18
21373265-1	2011	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the catabolism of heme, followed by production of biliverdin, free iron and carbon monoxide (CO).	Iron	122-126	heme oxygenase 1	Homo sapiens	0-16
21373265-1	2011	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the catabolism of heme, followed by production of biliverdin, free iron and carbon monoxide (CO).	Iron	122-126	heme oxygenase 1	Homo sapiens	18-22
20878427-1	2011	Iron and immunity are closely linked: firstly by the fact that many of the genes/proteins involved in iron homoeostasis play a vital role in controlling iron fluxes such that bacteria are prevented from utilising iron for growth; secondly, cells of the innate immune system, monocytes, macrophages, microglia and lymphocytes, are able to combat bacterial insults by carefully controlling their iron fluxes, which are mediated by hepcidin and ferroportin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	429-437
20878427-1	2011	Iron and immunity are closely linked: firstly by the fact that many of the genes/proteins involved in iron homoeostasis play a vital role in controlling iron fluxes such that bacteria are prevented from utilising iron for growth; secondly, cells of the innate immune system, monocytes, macrophages, microglia and lymphocytes, are able to combat bacterial insults by carefully controlling their iron fluxes, which are mediated by hepcidin and ferroportin.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	429-437
21161302-13	2011	Moreover, transferrin/transferrin receptor 2 mediated transport of iron into the mitochondria of these neurons was identified together with increased transferrin immunoreactivity.	Iron	67-71	transferrin receptor 2	Homo sapiens	22-44
21705976-2	2011	In nontransfused beta thalassemia patients, erythropoiesis,anemia and hypoxia down-regulate hepcidin, the master regulator of iron homeostasis.	Iron	126-130	hepcidin antimicrobial peptide	Homo sapiens	92-100
21705976-3	2011	Hepcidin deficiency in turn allows excessive duodenal iron absorption and development of systemic iron overload.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
21705976-3	2011	Hepcidin deficiency in turn allows excessive duodenal iron absorption and development of systemic iron overload.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
20966077-1	2011	Hepcidin is a liver-derived hormone with a key role in iron homeostasis.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	0-8
21283930-1	2011	The iron is the main component of hemoglobin and is also part of myoglobin and enzymes.	Iron	4-8	myoglobin	Homo sapiens	65-74
21143008-0	2011	Mass spectrometry measurement of plasma hepcidin for the prediction of iron overload.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	40-48
21143008-1	2011	BACKGROUND: Hepcidin has emerged as the primary regulator of iron homeostasis.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	12-20
21454222-1	2011	Waldenstrom"s macroglobulinemia (WM) patients often present with anemia as their primary disease manifestation that may be related to hepcidin, an important regulator of iron homeostasis.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	134-142
21454222-4	2011	No correlation with serum iron indices was observed, though in patients with high hepcidin levels, increased iron deposition in bone marrow macrophages was observed.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	82-90
20739232-3	2011	Indeed, deregulation of the transcription of hepcidin, emerging as the master regulator of systemic iron metabolism, has been implicated in the pathogenesis of hepatic iron overload in chronic liver diseases.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	45-53
20952515-0	2011	Iron overload induces BMP6 expression in the liver but not in the duodenum.	Iron	0-4	bone morphogenetic protein 6	Mus musculus	22-26
20952515-6	2011	RESULTS: We showed that iron overload induces Bmp6 mRNA expression in the liver but not in the duodenum of these mice.	Iron	24-28	bone morphogenetic protein 6	Mus musculus	46-50
20952515-7	2011	Bmp6 is also detected by immunohistochemistry in liver tissue sections of mice with iron overload induced either by an iron-enriched diet or by inactivation of the Hfe gene, but not in liver tissue sections from iron-loaded Bmp6-deficient mice.	Iron	84-88	bone morphogenetic protein 6	Mus musculus	0-4
20952515-7	2011	Bmp6 is also detected by immunohistochemistry in liver tissue sections of mice with iron overload induced either by an iron-enriched diet or by inactivation of the Hfe gene, but not in liver tissue sections from iron-loaded Bmp6-deficient mice.	Iron	119-123	bone morphogenetic protein 6	Mus musculus	0-4
20952515-7	2011	Bmp6 is also detected by immunohistochemistry in liver tissue sections of mice with iron overload induced either by an iron-enriched diet or by inactivation of the Hfe gene, but not in liver tissue sections from iron-loaded Bmp6-deficient mice.	Iron	119-123	bone morphogenetic protein 6	Mus musculus	0-4
20952515-10	2011	CONCLUSIONS: Our data strongly support the importance of liver BMP6 for regulation of iron metabolism.	Iron	86-90	bone morphogenetic protein 6	Mus musculus	63-67
20952515-11	2011	Indeed, they demonstrate that intestinal Bmp6 expression is modulated by iron neither at the mRNA nor at the protein level.	Iron	73-77	bone morphogenetic protein 6	Mus musculus	41-45
21135132-1	2011	The yeast Cth2 protein is a CX(8)CX(5)CX(3)H tandem zinc finger protein that binds AU-rich element (ARE)-containing transcripts to enhance their decay in response to iron (Fe) deficiency.	Iron	166-170	Tis11p	Saccharomyces cerevisiae S288C	10-14
21135132-1	2011	The yeast Cth2 protein is a CX(8)CX(5)CX(3)H tandem zinc finger protein that binds AU-rich element (ARE)-containing transcripts to enhance their decay in response to iron (Fe) deficiency.	Iron	172-174	Tis11p	Saccharomyces cerevisiae S288C	10-14
21135132-6	2011	Taken together, our data suggest that under conditions of Fe deficiency Cth2 travels into the nucleus to recruit target mRNAs, perhaps cotranscriptionally, that are destined for cytosolic degradation as part of the mechanism of adaptation to growth under Fe limitation.	Iron	58-60	Tis11p	Saccharomyces cerevisiae S288C	72-76
21076043-1	2011	Hepcidin is a major regulator of iron homeostasis, and its expression in liver is regulated by iron, inflammation, and erythropoietic activity with mechanisms that involve bone morphogenetic proteins (BMPs) binding their receptors and coreceptors.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
21158393-2	2011	FeCl(2) and CuCl showed, respectively, almost the same and slightly lower activities compared with FeCl(3) in the tert-butoxylation of N-phenylpyrrolidone (1a), whereas no tert-butoxylated product was obtained by use of Fe(OTf)(3), RuCl(3), or Zr(OTf)(4).	Iron	0-2	POU class 5 homeobox 1	Homo sapiens	244-254
21725759-7	2011	Our results indicate that TPC reduction of iron-induced neuronal death may be through the p44/42 MAPK /p70 S6K signal transduction pathway.	Iron	43-47	ribosomal protein S6 kinase B1	Rattus norvegicus	103-110
21687645-0	2011	Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation: Does This Protect from Excessive Parenchymal Iron Loading?	Iron	182-186	hepcidin antimicrobial peptide	Homo sapiens	22-30
21687645-1	2011	Hepcidin is upregulated by inflammation and iron.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
21212218-3	2011	Mothers had relatively high hepcidin levels considering their low iron status.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	28-36
20887198-1	2011	The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	28-36
20887198-2	2011	Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	25-33
20887198-3	2011	Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
20887198-4	2011	The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	4-12
21109502-0	2011	Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson"s disease.	Iron	73-77	ceruloplasmin	Homo sapiens	16-29
21109502-8	2011	Specifically, in the subset of patients with Parkinson"s disease exhibiting reduced levels of serum ceruloplasmin, we found lowered nigral bilateral average phase values, suggesting increased nigral iron content, while those patients with normal levels of serum ceruloplasmin exhibited no changes as compared with control subjects.	Iron	199-203	ceruloplasmin	Homo sapiens	100-113
21109502-9	2011	These findings suggest that decreased levels of serum ceruloplasmin may specifically exacerbate nigral iron deposition in patients with Parkinson"s disease.	Iron	103-107	ceruloplasmin	Homo sapiens	54-67
22187543-2	2011	We investigated whether changes in CP were reflected by altered iron parameters in AD patients.	Iron	64-68	ceruloplasmin	Homo sapiens	35-37
22187543-8	2011	As CP concentration only rises with age in the controls, this may indicate failing adaption to age-related alterations in iron metabolism in AD patients.	Iron	122-126	ceruloplasmin	Homo sapiens	3-5
22160085-2	2011	Hepcidin, a circulating hormone that is synthesized by the liver, has emerged as a key regulator of systemic iron homeostasis.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	0-8
22160085-3	2011	Hepcidin inhibits the absorption of dietary iron from the intestine and the release of iron derived from red blood cells from macrophages.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
22160085-3	2011	Hepcidin inhibits the absorption of dietary iron from the intestine and the release of iron derived from red blood cells from macrophages.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	0-8
22160085-4	2011	Therefore, variation in hepcidin levels modifies the total amount of iron stored in the body and the availability of iron for erythropoiesis.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	24-32
22160085-4	2011	Therefore, variation in hepcidin levels modifies the total amount of iron stored in the body and the availability of iron for erythropoiesis.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	24-32
22160085-5	2011	The production of hepcidin by the liver is modulated by multiple physiological stimuli, including iron loading, inflammation, and erythropoietic activity.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	18-26
22160086-0	2011	The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	4-12
22160086-1	2011	The review summarizes the current understanding of the role of hepcidin and ferroportin in normal iron homeostasis and its disorders.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	63-71
22160086-2	2011	The various approaches to therapeutic targeting of hepcidin and ferroportin in iron-overload disorders (mainly hereditary hemochromatosis and beta-thalassemia) and iron-restrictive anemias (anemias associated with infections, inflammatory disorders, and certain malignancies, anemia of chronic kidney diseases, and iron-refractory iron-deficiency anemia) are also discussed.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	51-59
21210258-6	2011	Genetic disorders of iron overload of iron-linked anemia can be explained by changes in the level of hepcidin or ferroportin and of the ability of ferroportin to be internalized by hepcidin.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	181-189
21210258-6	2011	Genetic disorders of iron overload of iron-linked anemia can be explained by changes in the level of hepcidin or ferroportin and of the ability of ferroportin to be internalized by hepcidin.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	101-109
21210258-6	2011	Genetic disorders of iron overload of iron-linked anemia can be explained by changes in the level of hepcidin or ferroportin and of the ability of ferroportin to be internalized by hepcidin.	Iron	38-42	hepcidin antimicrobial peptide	Homo sapiens	181-189
21123956-11	2011	Hypoxia mimetic iron chelator deferroxamine promoted p53 accumulation in H9c2 myoblast cells by suppressing the Akt/MDM2 pathway, which was restored by ATR.	Iron	16-20	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	53-56
20932599-3	2011	The notion that hepcidin excess or deficiency may contribute to the dysregulation of iron homeostasis in hereditary and acquired iron disorders raises the possibility that hepcidin-lowering or enhancing agents may be an effective strategy for curing the main consequences of hepcidinopathies, anemia or iron overload, respectively.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	172-180
20932599-3	2011	The notion that hepcidin excess or deficiency may contribute to the dysregulation of iron homeostasis in hereditary and acquired iron disorders raises the possibility that hepcidin-lowering or enhancing agents may be an effective strategy for curing the main consequences of hepcidinopathies, anemia or iron overload, respectively.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	16-24
20932599-5	2011	While future studies addressing safety and long-term efficacy of hepcidin-targeted treatments will clarify risks and benefits, a new era has begun based on the treatment of disorders of iron homeostasis through the modulation of its regulatory hormone, hepcidin.	Iron	186-190	hepcidin antimicrobial peptide	Homo sapiens	253-261
20941616-1	2011	Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory stimuli.	Iron	167-171	heme oxygenase 1	Homo sapiens	0-16
20941616-1	2011	Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory stimuli.	Iron	167-171	heme oxygenase 1	Homo sapiens	18-22
20955171-2	2011	It was later demonstrated that hepcidin is in fact the long sought hormone that regulates iron homeostasis in mammals.	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	31-39
22125467-1	2011	Hepcidin is the main regulator of systemic iron homeostasis and is primarily produced by the liver but is also expressed, at the mRNA-level, in periphery tissues including the subcutaneous and visceral adipose tissue.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
22125467-2	2011	Obesity is associated with elevated hepcidin concentrations and iron depletion suggesting that the exaggerated fat mass in obesity could contribute significantly to circulating hepcidin levels consequently altering iron homeostasis.	Iron	215-219	hepcidin antimicrobial peptide	Homo sapiens	177-185
21182221-2	2010	Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin, free iron and carbon monoxide.	Iron	104-108	heme oxygenase 1	Homo sapiens	0-16
21182221-2	2010	Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin, free iron and carbon monoxide.	Iron	104-108	heme oxygenase 1	Homo sapiens	18-22
20858222-6	2010	When exposed to zinc, pif1Delta cells show lower induction of genes encoding iron (siderophores) transporters and higher expression of genes related to oxidative stress responses than wild-type cells.	Iron	77-81	DNA helicase PIF1	Saccharomyces cerevisiae S288C	22-26
20713168-4	2010	Heme oxygenase-1 (HO-1), an inducible enzyme, catalyzes the oxidative degradation of heme to free iron, carbon monoxide, and biliverdin, the latter being subsequently converted into bilirubin.	Iron	98-102	heme oxygenase 1	Homo sapiens	0-16
20713168-4	2010	Heme oxygenase-1 (HO-1), an inducible enzyme, catalyzes the oxidative degradation of heme to free iron, carbon monoxide, and biliverdin, the latter being subsequently converted into bilirubin.	Iron	98-102	heme oxygenase 1	Homo sapiens	18-22
20860551-3	2010	AHSP (alpha-haemoglobin-stabilizing protein) has been shown previously to bind alphah and regulate redox activity of the haem iron.	Iron	126-130	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
20868356-4	2010	HO-1 is the enzyme responsible for the conversion of the heme group to billiverdin, carbon monoxide and iron; a highly regulated cytoprotective enzyme able to respond to numerous chemical or physical stressors, many of which decrease oxygen availability and generate oxidative stress.	Iron	104-108	heme oxygenase 1	Homo sapiens	0-4
20704550-1	2010	Heme oxygenase-1 (HO-1) metabolizes heme to generate carbon monoxide (CO), biliverdin, and iron.	Iron	91-95	heme oxygenase 1	Homo sapiens	18-22
20704552-4	2010	HO-1 degrades heme to biliverdin-IXalpha, carbon monoxide (CO), and iron.	Iron	68-72	heme oxygenase 1	Homo sapiens	0-4
20736824-1	2010	PURPOSE OF REVIEW: In this review, we discuss the potential role of urinary hepcidin, a 2.8-kDa hormonal regulator of iron metabolism, as a biomarker of acute kidney injury (AKI) after cardiopulmonary bypass.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	76-84
20736824-5	2010	SUMMARY: Smaller increases in urinary hepcidin, a central regulator of iron metabolism, may be associated with greater risk of AKI after cardiopulmonary bypass.	Iron	71-75	hepcidin antimicrobial peptide	Homo sapiens	38-46
20939738-5	2010	The possible association of sequence variations in the mitochondrial ferritin (FtMt) gene with disorders with aberrant iron distribution has not been investigated yet.	Iron	119-123	ferritin mitochondrial	Homo sapiens	55-77
20939738-5	2010	The possible association of sequence variations in the mitochondrial ferritin (FtMt) gene with disorders with aberrant iron distribution has not been investigated yet.	Iron	119-123	ferritin mitochondrial	Homo sapiens	79-83
21039223-0	2010	Hemojuvelin and hepcidin genes sequencing in Brazilian patients with primary iron overload.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	16-24
20877286-2	2010	Hepcidin is the main regulator of iron homeostasis and is higher in obese children compared to controls.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
20877286-8	2010	In conclusion, we have shown that, in obese children, BMI reduction is associated with hepcidin reduction, potentially improving iron status and absorption.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	87-95
21099112-5	2010	These observations led us to hypothesize that more iron is absorbed in beta-thalassemia than is required for erythropoiesis and that increasing the concentration of hepcidin in the body of such patients might be therapeutic, limiting iron overload.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	165-173
21099112-5	2010	These observations led us to hypothesize that more iron is absorbed in beta-thalassemia than is required for erythropoiesis and that increasing the concentration of hepcidin in the body of such patients might be therapeutic, limiting iron overload.	Iron	234-238	hepcidin antimicrobial peptide	Homo sapiens	165-173
21122575-5	2010	The transcription of hepcidin is controlled by the iron status of the body, hypoxia, and/or inflammation.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	21-29
20956992-4	2010	Oral iron is inferior to intravenous iron in patients on hemodialysis, in part because elevated serum levels of hepcidin prevent intestinal absorption of iron.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	112-120
20956992-5	2010	Increased levels of hepcidin also impair the normal recycling of iron through the reticuloendothelial system.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	20-28
21041280-2	2010	The recent discovery of hepcidin has regenerated the research on iron metabolism.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	24-32
21038894-8	2010	The effects of iron on the system of DBH-BSA have also been investigated.	Iron	15-19	dopamine beta-hydroxylase	Homo sapiens	37-40
21038894-9	2010	It is found that iron could compete against BSA to bind DBH.	Iron	17-21	dopamine beta-hydroxylase	Homo sapiens	56-59
21054916-5	2010	The central regulator of body iron trafficking is the liver-derived peptide hepcidin.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	76-84
21054916-6	2010	Hepcidin limits iron entry into the plasma from macrophages, intestinal enterocytes and other cells by binding to the sole iron-export protein ferroportin, and facilitating its removal from the plasma membrane.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	0-8
21054916-6	2010	Hepcidin limits iron entry into the plasma from macrophages, intestinal enterocytes and other cells by binding to the sole iron-export protein ferroportin, and facilitating its removal from the plasma membrane.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	0-8
21054916-7	2010	Mutations in hepcidin or its upstream regulators (HFE, TFR2, HFE2 and BMP6) lead to reduced or absent hepcidin expression and a concomitant increase in iron absorption.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	13-21
21054916-7	2010	Mutations in hepcidin or its upstream regulators (HFE, TFR2, HFE2 and BMP6) lead to reduced or absent hepcidin expression and a concomitant increase in iron absorption.	Iron	152-156	transferrin receptor 2	Homo sapiens	55-59
21054916-7	2010	Mutations in hepcidin or its upstream regulators (HFE, TFR2, HFE2 and BMP6) lead to reduced or absent hepcidin expression and a concomitant increase in iron absorption.	Iron	152-156	hemojuvelin BMP co-receptor	Homo sapiens	61-65
22043450-0	2010	Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis.	Iron	20-24	hemojuvelin BMP co-receptor	Homo sapiens	44-55
22043450-0	2010	Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis.	Iron	20-24	hepcidin antimicrobial peptide	Homo sapiens	56-64
22043450-5	2010	Hepcidin expression is regulated positively by body iron load.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
22043450-6	2010	Although the underlying mechanism of iron-regulated hepcidin expression has not been fully elucidated, several proteins have been identified that participate in this process.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	52-60
22043450-8	2010	HJV undergoes complicated post-translational processing in an iron-dependent manner, and it interacts with multiple proteins that are essential for iron homeostasis.	Iron	62-66	hemojuvelin BMP co-receptor	Homo sapiens	0-3
22043450-8	2010	HJV undergoes complicated post-translational processing in an iron-dependent manner, and it interacts with multiple proteins that are essential for iron homeostasis.	Iron	148-152	hemojuvelin BMP co-receptor	Homo sapiens	0-3
21142632-1	2010	Hepcidin is a key regulator controlling iron intestinal absorption and distribution through the body.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
20634490-2	2010	BACKGROUND: Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	35-43
20634490-2	2010	BACKGROUND: Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.	Iron	59-63	transferrin receptor 2	Homo sapiens	139-161
20800005-1	2010	Lactoferrin (Lf) is a molecule naturally present in bovine milk that affects the availability and transport systems of iron.	Iron	119-123	lactotransferrin	Bos taurus	0-11
20533066-10	2010	In contrast, 3 patients with ferroportin disease and 7 with secondary iron overload syndromes showed serum hepcidin levels parallel to their hyperferritinemia.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	107-115
20691492-4	2010	SLC40A1 encodes a cellular iron exporter expressed in macrophages, enterocytes, and hepatocytes.	Iron	27-31	solute carrier family 40 member 1	Homo sapiens	0-7
20727382-1	2010	Previously, we demonstrated that IL-1beta was able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis.	Iron	63-67	solute carrier family 40 member 1	Homo sapiens	131-144
20727382-1	2010	Previously, we demonstrated that IL-1beta was able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis.	Iron	63-67	solute carrier family 40 member 1	Homo sapiens	146-149
20727382-1	2010	Previously, we demonstrated that IL-1beta was able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis.	Iron	63-67	ceruloplasmin	Homo sapiens	155-168
20940119-1	2010	UNLABELLED: Hepcidin is an endogenous substance that inhibits iron absorption and plasma iron levels.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	12-20
20940119-1	2010	UNLABELLED: Hepcidin is an endogenous substance that inhibits iron absorption and plasma iron levels.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	12-20
20940119-8	2010	These results indicate a possible causative relationship between increased hepcidin and decreased iron levels.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	75-83
20940119-9	2010	In clinical practice, determination of hepcidin levels may be indicated for characterization and, possibly, prediction of postoperative iron homeostasis.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	39-47
20670216-5	2010	The decreased expression of CTR1 results in cellular copper deficiency and inhibition of Fet3 activity, which eventually impairs iron uptake.	Iron	129-133	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	28-32
20800515-3	2010	Research on iron metabolism has highlighted the importance of hepcidin and its potential role in development of anemia of inflammation (AI).	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	62-70
20800515-4	2010	Hepcidin is a peptide that controls iron flow, is induced by inflammation and is speculated to cause the sequestration of iron in patients with inflammation.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	0-8
20800515-4	2010	Hepcidin is a peptide that controls iron flow, is induced by inflammation and is speculated to cause the sequestration of iron in patients with inflammation.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	0-8
20406137-6	2010	The prevention of cytosolic ferritin degradation in MtFt-expressing cells significantly blocked iron mobilization from the protein cage induced by MtFt expression.	Iron	96-100	ferritin mitochondrial	Homo sapiens	52-56
20406137-6	2010	The prevention of cytosolic ferritin degradation in MtFt-expressing cells significantly blocked iron mobilization from the protein cage induced by MtFt expression.	Iron	96-100	ferritin mitochondrial	Homo sapiens	147-151
20528904-1	2010	OBJECTIVES: Hepcidin is the key regulator of iron homeostasis.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	12-20
20836490-7	2010	Following iron addition to the devegetated sediments, porewater S[-II] concentrations decreased for each dose relative to the control with the average weekly export of MeHg in the surface water decreased by 82% and 89% for the two highest doses, respectively.	Iron	10-14	transcription elongation factor A1	Homo sapiens	64-69
20668094-0	2010	Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis.	Iron	83-87	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	30-35
21462109-6	2010	Hepcidin levels are higher in obese individuals and are linked to subclinical inflammation; this may reduce iron absorption and blunt the effects of iron fortification.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	0-8
21462109-6	2010	Hepcidin levels are higher in obese individuals and are linked to subclinical inflammation; this may reduce iron absorption and blunt the effects of iron fortification.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	0-8
21462112-5	2010	The interaction between Ca and Fe may be a lumenal event, affecting Fe uptake through DMT1 (divalent metal transporter 1) at the apical membrane.	Iron	31-33	solute carrier family 11 member 2	Homo sapiens	86-90
21462112-5	2010	The interaction between Ca and Fe may be a lumenal event, affecting Fe uptake through DMT1 (divalent metal transporter 1) at the apical membrane.	Iron	31-33	solute carrier family 11 member 2	Homo sapiens	92-120
21462112-5	2010	The interaction between Ca and Fe may be a lumenal event, affecting Fe uptake through DMT1 (divalent metal transporter 1) at the apical membrane.	Iron	68-70	solute carrier family 11 member 2	Homo sapiens	86-90
21462112-5	2010	The interaction between Ca and Fe may be a lumenal event, affecting Fe uptake through DMT1 (divalent metal transporter 1) at the apical membrane.	Iron	68-70	solute carrier family 11 member 2	Homo sapiens	92-120
20631677-0	2010	Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure.	Iron	36-40	erythropoietin	Rattus norvegicus	0-14
20631677-2	2010	The mechanism by which erythropoietin improves iron homeostasis is still unclear, but it may involve suppression of the iron regulatory peptide hepcidin and/or a direct effect on intestinal iron absorption.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	144-152
20631677-2	2010	The mechanism by which erythropoietin improves iron homeostasis is still unclear, but it may involve suppression of the iron regulatory peptide hepcidin and/or a direct effect on intestinal iron absorption.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	144-152
20622253-4	2010	Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs.	Iron	18-20	nei like DNA glycosylase 1	Homo sapiens	72-77
20622253-4	2010	Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs.	Iron	18-20	8-oxoguanine DNA glycosylase	Homo sapiens	311-319
20822529-3	2010	Deleterious free heme is degraded by HO-1 to carbon monoxide, iron and biliverdin, which have potent anti-oxidant and anti-inflammatory properties.	Iron	62-66	heme oxygenase 1	Homo sapiens	37-41
20460119-1	2010	BACKGROUND: Iron deficiency and the Q248H mutation in the gene, SLC40A1, that encodes for the cellular iron exporter, ferroportin, are both common in African children.	Iron	103-107	solute carrier family 40 member 1	Homo sapiens	64-71
24431481-0	2010	RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for ATM, RAD9 and BRCA1.	Iron	32-36	ATM serine/threonine kinase	Homo sapiens	78-81
24431481-5	2010	Our results show that cells heterozygous for both Atm and Rad9 or Atm and Brca1 have high survival rates and are more sensitive to transformation by high energy Iron ions when compared with wild-type controls or cells haploinsufficient for only one of these proteins.	Iron	161-165	ATM serine/threonine kinase	Homo sapiens	50-53
24431481-5	2010	Our results show that cells heterozygous for both Atm and Rad9 or Atm and Brca1 have high survival rates and are more sensitive to transformation by high energy Iron ions when compared with wild-type controls or cells haploinsufficient for only one of these proteins.	Iron	161-165	ATM serine/threonine kinase	Homo sapiens	66-69
20576915-0	2010	Transferrin receptor 2 is crucial for iron sensing in human hepatocytes.	Iron	38-42	transferrin receptor 2	Homo sapiens	0-22
20576915-1	2010	Hepcidin expression in vivo is regulated in proportion to iron status (i.e., increased by iron loading and decreased in iron deficiency).	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
20576915-1	2010	Hepcidin expression in vivo is regulated in proportion to iron status (i.e., increased by iron loading and decreased in iron deficiency).	Iron	90-94	hepcidin antimicrobial peptide	Homo sapiens	0-8
20576915-2	2010	However, in vitro studies with hepatoma cell lines often show an inverse relationship between iron status and hepcidin expression.	Iron	94-98	hepcidin antimicrobial peptide	Homo sapiens	110-118
20576915-10	2010	Taken together our data suggest that transferrin receptor 2 is a likely candidate to explain the differences in iron sensing between hepatoma cell lines and primary human hepatocytes.	Iron	112-116	transferrin receptor 2	Homo sapiens	37-59
20805568-16	2010	Iron storage in ferritin was greatly reduced by FHsiRNA, resulting in increased iron availability, as noted by a decrease in transferrin receptor levels and iron uptake from transferrin.	Iron	0-4	inhibitor of carbonic anhydrase	Canis lupus familiaris	125-136
20805568-16	2010	Iron storage in ferritin was greatly reduced by FHsiRNA, resulting in increased iron availability, as noted by a decrease in transferrin receptor levels and iron uptake from transferrin.	Iron	0-4	inhibitor of carbonic anhydrase	Canis lupus familiaris	174-185
20805568-16	2010	Iron storage in ferritin was greatly reduced by FHsiRNA, resulting in increased iron availability, as noted by a decrease in transferrin receptor levels and iron uptake from transferrin.	Iron	157-161	inhibitor of carbonic anhydrase	Canis lupus familiaris	174-185
20805568-17	2010	Increased iron availability also increased cystine uptake and glutathione concentration and decreased nuclear translocation of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor (VEGF) accumulation in the cell-conditioned medium.	Iron	10-14	hypoxia inducible factor 1 subunit alpha	Canis lupus familiaris	127-159
20583136-2	2010	However, the molecular mechanisms of APN-mediated COX-2 induction and its protection against iron-mediated injury in hepatocytes are still unclear.	Iron	93-97	adiponectin, C1Q and collagen domain containing	Mus musculus	37-40
20583136-5	2010	Interestingly, beraprost and misoprostol, respective agonists for PGI2 and PGE2, mimicked the protective effects of APN in iron-mediated inflammation in hepatocytes.	Iron	123-127	adiponectin, C1Q and collagen domain containing	Mus musculus	116-119
20583136-8	2010	Herein, we demonstrate that APN-mediated COX-2 induction through a PPARalpha-dependent mechanism, and COX-2 exerted an anti-inflammatory effect of APN in hepatocytes subjected to iron challenge.	Iron	179-183	adiponectin, C1Q and collagen domain containing	Mus musculus	28-31
20583136-8	2010	Herein, we demonstrate that APN-mediated COX-2 induction through a PPARalpha-dependent mechanism, and COX-2 exerted an anti-inflammatory effect of APN in hepatocytes subjected to iron challenge.	Iron	179-183	adiponectin, C1Q and collagen domain containing	Mus musculus	147-150
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	S-adenosylmethionine synthetase 1	Arabidopsis thaliana	105-111
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	1-aminocyclopropane-1-carboxylic acid (acc) synthase 6	Arabidopsis thaliana	129-135
20797577-1	2010	BACKGROUND: Accumulating data suggest potential clinical relevant relationships between hepcidin-25 levels, iron stores, erythropoiesis effectiveness, and epoetin dose.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	88-96
20797577-3	2010	OBJECTIVE: To investigate hepcidin levels and their relationship with peripheral iron indices, inflammation, and anemia therapy in patients on hemodialysis (HD).	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	26-34
20797577-8	2010	Lower hepcidin levels were associated with higher transferrin levels (odds ratio 1.05 [1.01-1.09]), bigger iron doses (odds ratio 1.09 [1.02-1.15]), and an increased darbepoetin resistance index (odds ratio 4.3E+15 [11.15-1.6E+30]).	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	6-14
20797577-12	2010	CONCLUSION: A low hepcidin level in hemodialysis patients with high epoetin resistance index could be a useful marker of iron-restricted erythropoiesis, but confirmation by a therapeutical trial is necessary.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	18-26
21117298-2	2010	Bacterial pathogens could multiply in the animal body because they produce iron-binding siderophores that help them to obtain iron from transferrin, lactoferrin or ferritin of their host.	Iron	75-79	lactotransferrin	Mus musculus	149-160
21117298-2	2010	Bacterial pathogens could multiply in the animal body because they produce iron-binding siderophores that help them to obtain iron from transferrin, lactoferrin or ferritin of their host.	Iron	126-130	lactotransferrin	Mus musculus	149-160
20509758-1	2010	This study highlights the iron profile of myelodysplastic patients in the era of hepcidin and its pro-hormone, pro-hepcidin.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	81-89
20509758-1	2010	This study highlights the iron profile of myelodysplastic patients in the era of hepcidin and its pro-hormone, pro-hepcidin.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	115-123
20509758-3	2010	We determined if pro-hepcidin played a role in iron overload in patients with myelodysplasia (MDS).	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	21-29
20600116-2	2010	The expression of p19 and an adjacent iron transporter homologue (ftr1) is strongly induced upon iron limitation, suggesting a function in iron acquisition.	Iron	38-42	interleukin 23 subunit alpha	Homo sapiens	18-21
20600116-2	2010	The expression of p19 and an adjacent iron transporter homologue (ftr1) is strongly induced upon iron limitation, suggesting a function in iron acquisition.	Iron	97-101	interleukin 23 subunit alpha	Homo sapiens	18-21
20600116-3	2010	Here, we show that the loss of P19 alone is detrimental to growth on iron-restricted media.	Iron	69-73	interleukin 23 subunit alpha	Homo sapiens	31-34
20600116-4	2010	Furthermore, metal binding analysis demonstrates that recombinant P19 has distinct copper and iron binding sites.	Iron	94-98	interleukin 23 subunit alpha	Homo sapiens	66-69
21161013-13	2010	However, hepcidin may play a role in gender-based differences in iron metabolism and liver diseases.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	9-17
20415583-0	2010	Iron-sensing proteins that regulate hepcidin and enteric iron absorption.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	36-44
20415583-3	2010	Iron absorption is controlled chiefly by hepcidin, the iron-regulatory hormone.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	41-49
20415583-4	2010	Produced by the liver and secreted into the circulation, hepcidin regulates iron metabolism by inhibiting iron release from cells, including duodenal enterocytes, which mediate the absorption of dietary iron.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	57-65
20415583-4	2010	Produced by the liver and secreted into the circulation, hepcidin regulates iron metabolism by inhibiting iron release from cells, including duodenal enterocytes, which mediate the absorption of dietary iron.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	57-65
20415583-4	2010	Produced by the liver and secreted into the circulation, hepcidin regulates iron metabolism by inhibiting iron release from cells, including duodenal enterocytes, which mediate the absorption of dietary iron.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	57-65
20415583-5	2010	Hepcidin production increases in response to iron loading and decreases in iron deficiency.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
20415583-6	2010	Such regulation of hepcidin expression serves to modulate iron absorption to meet body iron demand.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	19-27
20415583-6	2010	Such regulation of hepcidin expression serves to modulate iron absorption to meet body iron demand.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	19-27
20808936-9	2010	Several biological processes such as mitochondrial metabolic pathways, lipid metabolic and catabolic processes, lipid biosynthetic processes, carboxylic acid metabolic processes, iron ion binding and glutathione S-transferases were downregulated after leptin administration.	Iron	179-183	leptin	Mus musculus	252-258
20586408-4	2010	In this work, the processes of accumulation and incorporation of organometallic palladium complexes within the cage of the iron storage protein apo-ferritin (apo-Fr) are elucidated by analysis of X-ray crystal structures of apo-Fr and selected mutants thereof, in the presence of the metal complexes.	Iron	123-127	ferritin heavy chain 1	Homo sapiens	144-156
20394798-0	2010	Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.	Iron	60-64	solute carrier family 11 member 2	Homo sapiens	16-20
20394798-6	2010	Compared to macrophages singly deficient in either DMT1 or Nramp1 transport ability, macrophages where DMT1 and Nramp1 were both compromised exhibited an abrogated increase in labile iron pool content, released less iron, and experienced diminished upregulation of ferroportin and heme-oxygenase 1 levels following erythrophagocytosis.	Iron	183-187	solute carrier family 11 member 2	Homo sapiens	103-107
20394798-7	2010	CONCLUSIONS: These results suggest that although the loss of either Nramp1 or DMT1 transport ability results in minor impairment after erythrophagocytosis, the simultaneous loss of both Nramp1 and DMT1 iron transport activity is detrimental to the iron recycling capacity of the macrophage.	Iron	202-206	solute carrier family 11 member 2	Homo sapiens	197-201
20394798-7	2010	CONCLUSIONS: These results suggest that although the loss of either Nramp1 or DMT1 transport ability results in minor impairment after erythrophagocytosis, the simultaneous loss of both Nramp1 and DMT1 iron transport activity is detrimental to the iron recycling capacity of the macrophage.	Iron	248-252	solute carrier family 11 member 2	Homo sapiens	197-201
20537480-0	2010	The iron driven pathway of hepcidin synthesis.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	27-35
20537480-3	2010	Iron losses being not adaptable, iron balance is controlled only through intestinal iron absorption which is regulated by the hepatic peptide hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	142-150
20537480-3	2010	Iron losses being not adaptable, iron balance is controlled only through intestinal iron absorption which is regulated by the hepatic peptide hepcidin.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	142-150
20537480-3	2010	Iron losses being not adaptable, iron balance is controlled only through intestinal iron absorption which is regulated by the hepatic peptide hepcidin.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	142-150
20681027-0	2010	Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia-inducible factor-1.	Iron	22-34	solute carrier family 11 member 2	Homo sapiens	80-108
20681027-0	2010	Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia-inducible factor-1.	Iron	22-34	solute carrier family 11 member 2	Homo sapiens	110-114
20681027-2	2010	Divalent metal transporter 1 (DMT1) is a transmembrane protein that is important in divalent metal ion transport, in particular iron.	Iron	128-132	solute carrier family 11 member 2	Homo sapiens	0-28
20681027-2	2010	Divalent metal transporter 1 (DMT1) is a transmembrane protein that is important in divalent metal ion transport, in particular iron.	Iron	128-132	solute carrier family 11 member 2	Homo sapiens	30-34
20681027-6	2010	Both the total cellular iron and ferrous uptake increased after hypoxia, decreased after DMT1 RNA interference.	Iron	24-28	solute carrier family 11 member 2	Homo sapiens	89-93
20681027-7	2010	Reactive oxygen species (ROS) were also changed by +iron responsive element (IRE) DMT1 exon1B overexpression.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	82-86
20681027-9	2010	Hypoxia might affect cellular iron uptake through regulating the expression of DMT1.	Iron	30-34	solute carrier family 11 member 2	Homo sapiens	79-83
20444958-9	2010	Serum hepcidin concentrations were not affected by BCT; however, hepcidin concentrations were lower in iron-deficient anemic soldiers than in those with normal iron status (P &lt; or = 0.05) and were positively associated with serum ferritin (P &lt; or = 0.05) and C-reactive protein (P &lt; or = 0.05) concentrations pre- and post-BCT.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	65-73
20444958-11	2010	Serum hepcidin concentrations were not affected by training but were associated with iron status and inflammation pre- and post-BCT.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	6-14
20480360-5	2010	However, UvrY mutation did not affect survival of F2-4 mutant in the presence of non-immune fish serum and its ability to grow under iron starvation.	Iron	133-137	UvrY/SirA/GacA family response regulator transcription factor	Yersinia ruckeri	9-13
21072151-3	2010	Inflammation interferes with iron utilization in chronic kidney disease through hepcidin.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	80-88
20675571-0	2010	The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.	Iron	59-63	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	30-36
20675571-3	2010	Functional analysis of PYE suggests that it positively regulates growth and development under iron-deficient conditions.	Iron	94-98	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	23-26
20675571-4	2010	Chromatin immunoprecipitation-on-chip analysis and transcriptional profiling reveal that PYE helps maintain iron homeostasis by regulating the expression of known iron homeostasis genes and other genes involved in transcription, development, and stress response.	Iron	108-112	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	89-92
20675571-4	2010	Chromatin immunoprecipitation-on-chip analysis and transcriptional profiling reveal that PYE helps maintain iron homeostasis by regulating the expression of known iron homeostasis genes and other genes involved in transcription, development, and stress response.	Iron	163-167	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	89-92
20675571-8	2010	We propose that interactions among PYE, PYE homologs, and BTS are important for maintaining iron homeostasis under low iron conditions.	Iron	92-96	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	35-38
20675571-8	2010	We propose that interactions among PYE, PYE homologs, and BTS are important for maintaining iron homeostasis under low iron conditions.	Iron	92-96	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	40-43
20675571-8	2010	We propose that interactions among PYE, PYE homologs, and BTS are important for maintaining iron homeostasis under low iron conditions.	Iron	119-123	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	35-38
20675571-8	2010	We propose that interactions among PYE, PYE homologs, and BTS are important for maintaining iron homeostasis under low iron conditions.	Iron	119-123	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	40-43
20446742-1	2010	Iron-containing ligands targeting the human histamine H(3) receptor (hH(3)R) were prepared.	Iron	0-4	histamine receptor H3	Homo sapiens	44-67
20446742-1	2010	Iron-containing ligands targeting the human histamine H(3) receptor (hH(3)R) were prepared.	Iron	0-4	histamine receptor H3	Homo sapiens	69-75
20525315-13	2010	These findings suggest that HCP1 and DMT1A-I have functions in the uptake of dietary heme and non-heme iron.	Iron	103-107	solute carrier family 46 member 1	Homo sapiens	28-32
20525315-15	2010	These localization studies support a model in which cytosolic heme can be degraded by HOs, and the resulting iron is exported into tissue fluids via the iron transporter ferroportin 1, which is expressed in the basolateral membrane in enterocytes or in the plasma membrane in macrophages.	Iron	109-113	solute carrier family 40 member 1	Homo sapiens	170-183
20364433-4	2010	Previously, we demonstrated that bovine lactoferrin was able to influence the efficiency of invasion of different iron-regulated morphological forms of B. cenocepacia.	Iron	114-118	lactotransferrin	Bos taurus	40-51
20364433-5	2010	Bovine lactoferrin showed to efficiently inhibit invasion of alveolar epithelial cells by free-living bacteria or iron-induced aggregates or biofilm.	Iron	114-118	lactotransferrin	Bos taurus	7-18
20407805-4	2010	Recently, we have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women suffering from ID and IDA.	Iron	81-85	lactotransferrin	Bos taurus	103-114
20124431-1	2010	Erythropoietic activity is known to affect iron homeostasis through regulation of the liver iron regulatory hormone hepcidin.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	116-124
20102409-1	2010	Hepcidin regulates intracellular iron levels by interacting with and promoting the degradation of ferroportin, a membrane protein and the only known cellular iron exporter.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
20102409-1	2010	Hepcidin regulates intracellular iron levels by interacting with and promoting the degradation of ferroportin, a membrane protein and the only known cellular iron exporter.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	0-8
20102409-2	2010	Studies of hepcidin expression and regulation have focused on its effects in innate immunity and as a regulator of systemic iron metabolism.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	11-19
20102409-5	2010	In summary, we show that hepcidin expression determines intracellular iron levels by regulating the expression of ferroportin, as described in other cells, and that inappropriately low expression of hepcidin impairs normal lymphocyte proliferation.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	25-33
20440072-7	2010	Increasing HIF-1alpha levels by inhibiting its degradation through iron chelation markedly improved insulin secretion and glucose tolerance in control mice fed a high-fat diet but not in beta-Hif1a-null mice.	Iron	67-71	hypoxia inducible factor 1, alpha subunit	Mus musculus	11-21
19890342-1	2010	OBJECTIVE: Prohepcidin (Pro-Hep), synthesized in the liver, is the prohormone of hepcidin (Hep), which reduces iron absorption in the gut; its synthesis is enhanced by inflammation and is reduced during hypoxia.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	28-31
20132520-4	2010	Comparison of the sequences of putative plastid transporters from Arabidopsis thaliana with those involved in cyanobacterial Fe transport identified two orthologs of the FutC protein, AtNAP11 and AtNAP14.	Iron	125-127	nucleosome assembly protein1;1	Arabidopsis thaliana	184-191
20620527-2	2010	We studied hepcidin correlations with markers of iron status and of inflammation among 134 prevalent recipients of heart allografts (OHT).	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	11-19
20620527-7	2010	Hepcidin correlated with total iron binding capacity, ferritin, IL-6, hemoglobin, erythrocyte count, cystatin C, NT-proBNP, creatinine, and GFR.	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	0-8
20447525-8	2010	Liver-type fatty acid-binding protein and alpha-1 microglobulin function as high-affinity heme-binding proteins in different species, while hepcidin is central to iron sequestration and when increased in the urine appears to protect from CPB-associated AKI.	Iron	163-167	hepcidin antimicrobial peptide	Homo sapiens	140-148
20353152-3	2010	The mechanism research revealed that TSC24 was not only an iron chelator but also a topoisomerase IIalpha catalytic inhibitor.	Iron	59-63	testis expressed 35	Homo sapiens	37-42
20942301-0	2010	[Hepcidin--newly-discovered regulator of iron metabolism].	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	1-9
20223678-9	2010	This is supported by the fact that during PDT ferritin is readily up-regulated, able to bind excess iron formed by the HO-1 action.	Iron	100-104	heme oxygenase 1	Homo sapiens	119-123
20226171-5	2010	Co-immunoprecipitation of 55-iron with Grx3/PICOT from Jurkat cells suggested the presence of these cofactors under physiological conditions.	Iron	29-33	glutaredoxin 3	Homo sapiens	39-43
20226171-5	2010	Co-immunoprecipitation of 55-iron with Grx3/PICOT from Jurkat cells suggested the presence of these cofactors under physiological conditions.	Iron	29-33	glutaredoxin 3	Homo sapiens	44-49
20060900-8	2010	To evaluate whether cellular iron status could influence Pin1, we treated the WT HFE cells with exogenous iron and found that Pin1 phosphorylation increased with increasing levels of iron.	Iron	29-33	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	57-61
20060900-8	2010	To evaluate whether cellular iron status could influence Pin1, we treated the WT HFE cells with exogenous iron and found that Pin1 phosphorylation increased with increasing levels of iron.	Iron	29-33	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	126-130
20060900-8	2010	To evaluate whether cellular iron status could influence Pin1, we treated the WT HFE cells with exogenous iron and found that Pin1 phosphorylation increased with increasing levels of iron.	Iron	106-110	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	126-130
20060900-8	2010	To evaluate whether cellular iron status could influence Pin1, we treated the WT HFE cells with exogenous iron and found that Pin1 phosphorylation increased with increasing levels of iron.	Iron	106-110	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	126-130
19940783-2	2010	Hepcidin has recently emerged as the key hormone in the regulation of iron balance and recycling.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
19453575-5	2010	This study was designed to utilize flow cytometric immunophenotyping to characterize effects of regular blood transfusion, and high serum ferritin levels because of irregular use of iron chelation therapy on T lymphocytes (CD2, CD3, CD4 and CD8), B lymphocytes (CD19) and natural killer cells (CD56) and zinc levels in the blood of patients with thalassemia major (n = 49) and healthy normal controls (n = 60) in Kuwait.	Iron	182-186	CD2 molecule	Homo sapiens	223-226
19624802-2	2010	The cellular iron status of the patients can be determined from the recently available measurement of reticulocyte hemoglobin equivalent (RET-He).	Iron	13-17	ret proto-oncogene	Homo sapiens	138-141
19624802-6	2010	Secondly, we investigated the changes in RET-He during iron supplementation for iron-deficient patients to determine whether this marker is a prospective and reliable indicator of iron sufficiency.	Iron	55-59	ret proto-oncogene	Homo sapiens	41-44
19624802-13	2010	Iron supplements given to the patients with low TSAT or ferritin, RET-He responded within 2 weeks, and this seemed to be a potential advantage of using RET-He in the estimation of iron status.	Iron	0-4	ret proto-oncogene	Homo sapiens	66-69
19624802-13	2010	Iron supplements given to the patients with low TSAT or ferritin, RET-He responded within 2 weeks, and this seemed to be a potential advantage of using RET-He in the estimation of iron status.	Iron	0-4	ret proto-oncogene	Homo sapiens	152-155
20005574-3	2010	The interaction between iron and alpha-syn might have important biological relevance to PD etiology.	Iron	24-28	synuclein alpha	Homo sapiens	33-42
20005574-10	2010	The roles of alpha-syn and its interaction with Fe(III) and/or Fe(II) are discussed in the context of oxidative stress, metal-catalyzed alpha-syn aggregation, and iron transfer processes.	Iron	163-167	synuclein alpha	Homo sapiens	13-22
20136718-2	2010	Lactoferrin (Lac) is an iron-binding glycoprotein that belongs to the transferrin family.	Iron	24-28	lactotransferrin	Mus musculus	0-11
20136718-2	2010	Lactoferrin (Lac) is an iron-binding glycoprotein that belongs to the transferrin family.	Iron	24-28	lactotransferrin	Mus musculus	0-3
20470305-3	2010	These cytokines can increase hepcidin production, which in turn reduces iron release from macrophages resulting in reduced availability of iron for erythropoiesis.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	29-37
20470305-3	2010	These cytokines can increase hepcidin production, which in turn reduces iron release from macrophages resulting in reduced availability of iron for erythropoiesis.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	29-37
20470305-15	2010	It is hypothesized that pentoxifylline improves iron disposition possibly through modulation of hepcidin.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	96-104
19619262-7	2010	Recent studies seem to indicate that obesity is associated with iron deficiency although the aetiology appears to be multifactorial and includes (i) A decrease in iron food intake; (ii) An impairment of intestinal iron uptake and iron release from stores because of an overexpression of hepcidin and (iii) Inadequate iron bioavailability because of inflammation.	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	287-295
20172583-8	2010	These observations on the effects of pH and iron-chelating agents indicate that oxidants formed on the surface or inside MS2 are responsible for the inactivation.	Iron	44-48	MS2	Homo sapiens	121-124
20118244-1	2010	Heme oxygenases (HOs) -1 and -2 catalyze the breakdown of heme to release carbon monoxide, biliverdin, and ferrous iron, which may preserve cell function during oxidative stress.	Iron	115-119	heme oxygenase 1	Homo sapiens	0-31
20200720-0	2010	Organic-soluble optically pure anionic metal complexes PPh4[M(III)(S,S-EDDS)].2H2O (M = Fe, Co, Cr).	Iron	88-90	potassium two pore domain channel subfamily K member 3	Homo sapiens	55-59
20698320-3	2010	Hepcidin has bactericidal properties and promotes iron retention in the enterocytes, macrophages, and hepatocytes through the internalization and degradation of ferroportin (a cell iron exporter into the plasma).	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	0-8
20698320-3	2010	Hepcidin has bactericidal properties and promotes iron retention in the enterocytes, macrophages, and hepatocytes through the internalization and degradation of ferroportin (a cell iron exporter into the plasma).	Iron	181-185	hepcidin antimicrobial peptide	Homo sapiens	0-8
20045050-11	2010	Our data support the importance of managing hepcidin levels before starting venesection therapy in patients with secondary iron overload that are eligible for phlebotomy.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	44-52
20333281-4	2010	Heme oxygenase-1 (HO-1) is catalyzing enzyme in heme breakdown process to release iron, carbon monoxide, and biliverdin/bilirubin, and may influence iron supply to the P. falciparum parasites.	Iron	82-86	heme oxygenase 1	Homo sapiens	0-16
20333281-4	2010	Heme oxygenase-1 (HO-1) is catalyzing enzyme in heme breakdown process to release iron, carbon monoxide, and biliverdin/bilirubin, and may influence iron supply to the P. falciparum parasites.	Iron	82-86	heme oxygenase 1	Homo sapiens	18-22
20333281-4	2010	Heme oxygenase-1 (HO-1) is catalyzing enzyme in heme breakdown process to release iron, carbon monoxide, and biliverdin/bilirubin, and may influence iron supply to the P. falciparum parasites.	Iron	149-153	heme oxygenase 1	Homo sapiens	0-16
20333281-4	2010	Heme oxygenase-1 (HO-1) is catalyzing enzyme in heme breakdown process to release iron, carbon monoxide, and biliverdin/bilirubin, and may influence iron supply to the P. falciparum parasites.	Iron	149-153	heme oxygenase 1	Homo sapiens	18-22
19854845-1	2010	BACKGROUND: Hepcidin is a key regulator of iron homeostasis and levels are elevated in patients with chronic kidney disease (CKD).	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	12-20
19854845-2	2010	Hepcidin may explain the often observed imbalance in iron metabolism in patients with CKD.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	0-8
20094679-1	2010	SERS spectra of 1,10-phenanthroline (phen) on iron smooth surface doped with silver nanoparticles have been recorded and compared with those previously obtained on Ag doped smooth silver, copper and nickel surfaces.	Iron	46-50	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
20019189-2	2010	Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mouse double minute gene 2 (MDM2), the ubiquitin ligase involved in the degradation of the oncosuppressor p53.	Iron	70-74	transformed mouse 3T3 cell double minute 2	Mus musculus	192-218
20019189-2	2010	Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mouse double minute gene 2 (MDM2), the ubiquitin ligase involved in the degradation of the oncosuppressor p53.	Iron	70-74	transformed mouse 3T3 cell double minute 2	Mus musculus	220-224
20019189-2	2010	Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mouse double minute gene 2 (MDM2), the ubiquitin ligase involved in the degradation of the oncosuppressor p53.	Iron	70-74	transformation related protein 53, pseudogene	Mus musculus	298-301
20019189-2	2010	Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mouse double minute gene 2 (MDM2), the ubiquitin ligase involved in the degradation of the oncosuppressor p53.	Iron	82-86	transformed mouse 3T3 cell double minute 2	Mus musculus	192-218
20019189-2	2010	Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mouse double minute gene 2 (MDM2), the ubiquitin ligase involved in the degradation of the oncosuppressor p53.	Iron	82-86	transformed mouse 3T3 cell double minute 2	Mus musculus	220-224
20019189-2	2010	Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mouse double minute gene 2 (MDM2), the ubiquitin ligase involved in the degradation of the oncosuppressor p53.	Iron	82-86	transformed mouse 3T3 cell double minute 2	Mus musculus	192-218
20019189-2	2010	Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed that iron downregulated, whereas deferoxamine upregulated, mRNA levels of mouse double minute gene 2 (MDM2), the ubiquitin ligase involved in the degradation of the oncosuppressor p53.	Iron	82-86	transformed mouse 3T3 cell double minute 2	Mus musculus	220-224
20019189-3	2010	Regulation of MDM2 by iron status was observed at protein levels in mouse hepatocytes and rat liver, and was associated with specular changes in p53 expression.	Iron	22-26	transformed mouse 3T3 cell double minute 2	Mus musculus	14-18
20019189-3	2010	Regulation of MDM2 by iron status was observed at protein levels in mouse hepatocytes and rat liver, and was associated with specular changes in p53 expression.	Iron	22-26	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	145-148
19756955-0	2010	Hepcidin mutation in a beta-thalassemia major patient with persistent severe iron overload despite chelation therapy.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
19663584-9	2010	Prussian blue staining for iron-based nanoprobes was used to confirm the specificity of the probe for VEGF-R2 in glioma tissue.	Iron	27-31	kinase insert domain receptor	Rattus norvegicus	102-109
20061265-0	2010	[Role of iron metabolism-regulator hepcidin in perinatal iron homeostasis].	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	35-43
20061265-0	2010	[Role of iron metabolism-regulator hepcidin in perinatal iron homeostasis].	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	35-43
20061265-1	2010	Hepcidin is a recently recognized defensin-like peptide, which is considered to be the central regulator of iron metabolism.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	0-8
20061265-2	2010	Hepcidin decreases the expression of iron transporting molecules.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
20061265-3	2010	Hepcidin reduces gastrointestinal iron absorption, iron release from the macrophages, and hence it decreases serum iron levels.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	0-8
20061265-3	2010	Hepcidin reduces gastrointestinal iron absorption, iron release from the macrophages, and hence it decreases serum iron levels.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	0-8
20061265-4	2010	Clarification of hepcidin role in iron homeostasis could provide an explanation to anemia of inflammation and chronic diseases.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	17-25
20061265-6	2010	The aim of our study was to develop an easily achievable, reliable quantification method for the determination of urine hepcidin levels in human, in addition to examine a possible association of hepcidin with neonatal iron homeostasis.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	195-203
20061265-15	2010	In summary, our results suggest a possible link between hepcidin and early iron adaptation of newborn"s, however, further investigations should be done to elucidate this issue.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	56-64
19819738-1	2010	Mutations in either the hereditary hemochromatosis protein, HFE, or transferrin receptor 2, TfR2, result in a similarly severe form of the most common type of iron overload disease called hereditary hemochromatosis.	Iron	159-163	transferrin receptor 2	Homo sapiens	68-90
19819738-1	2010	Mutations in either the hereditary hemochromatosis protein, HFE, or transferrin receptor 2, TfR2, result in a similarly severe form of the most common type of iron overload disease called hereditary hemochromatosis.	Iron	159-163	transferrin receptor 2	Homo sapiens	92-96
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	178-182	transferrin receptor 2	Homo sapiens	50-54
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	178-182	hepcidin antimicrobial peptide	Homo sapiens	203-211
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	233-237	transferrin receptor 2	Homo sapiens	50-54
19819738-2	2010	Models of the interactions between HFE, TfR1, and TfR2 imply that these proteins are present in different molar concentrations in the liver, where they control expression of the iron regulatory hormone, hepcidin, in response to body iron loading.	Iron	233-237	hepcidin antimicrobial peptide	Homo sapiens	203-211
19914207-3	2010	We recently characterized iron-dependent toxic alpha-syn oligomer species by confocal single molecule fluorescence techniques and used this aggregation model to identify several N"-benzylidene-benzohydrazide (NBB) derivatives inhibiting oligomer formation in vitro.	Iron	26-30	synuclein alpha	Homo sapiens	47-56
19914207-5	2010	Similar to our previous findings in vitro, we found a converse modulation of toxic alpha-syn oligomers by NBB derivates and ferric iron, which was characterized by an increase in aggregate formation by iron and an inhibitory effect of certain NBB compounds.	Iron	131-135	synuclein alpha	Homo sapiens	83-92
20225300-1	2010	Hepcidin is a four disulfide 25-residue peptide hormone which has a central role in the regulation of iron homeostasis.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	0-8
20036801-4	2010	However, a conformational change to the AHSP-bound alpha-Hb results in an oxidized heme, but in a pocket that is now less exposed to the outside environment, thereby protecting against both peroxide-induced heme loss and iron-induced redox reaction.	Iron	148-152	alpha hemoglobin stabilizing protein	Homo sapiens	40-44
21239806-7	2010	Hepcidin antimicrobial peptide has taken center stage in recent years as a potent modulator of iron availability.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	0-8
20157260-0	2010	Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.	Iron	21-25	presenilin 1	Mus musculus	90-93
20157260-6	2010	Yet increased astrocytosis, as revealed by densitometry of GFAP-immunoreactive astrocytes, and increased expression levels of GFAP, as revealed by gel electrophoresis and western blotting, were found in iron-treated mice (both Tg and Wt) when compared with TgSb and WtSb.	Iron	203-207	glial fibrillary acidic protein	Mus musculus	126-130
20502037-2	2010	Over the last few years, our understanding of iron metabolism has dramatically increased due to the discovery of hepcidin, which is produced by hepatocytes and modulated in response to anemia, hypoxia and inflammation.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	113-121
20502037-4	2010	The aim of this review is to summarize the current knowledge dealing with a possible role of hepcidin and NGAL in iron metabolism and its regulation, particularly in kidney disease.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	93-101
20502037-8	2010	Hepcidin, an antibacterial defensin, prevents iron absorption from the gut and iron release from macrophages, leading to hypoferremia and anemia.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	0-8
20502037-8	2010	Hepcidin, an antibacterial defensin, prevents iron absorption from the gut and iron release from macrophages, leading to hypoferremia and anemia.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	0-8
21117319-2	2010	Intracellular and systemic iron homeostasis is an important element in the defense against oxidative stress and is controlled by post-transcriptional regulatory mechanism IRP/IRE and hepcidin, a peptide that regulates iron absorption from diet and heme iron release by macrophages.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	183-191
21117319-2	2010	Intracellular and systemic iron homeostasis is an important element in the defense against oxidative stress and is controlled by post-transcriptional regulatory mechanism IRP/IRE and hepcidin, a peptide that regulates iron absorption from diet and heme iron release by macrophages.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	183-191
21117319-2	2010	Intracellular and systemic iron homeostasis is an important element in the defense against oxidative stress and is controlled by post-transcriptional regulatory mechanism IRP/IRE and hepcidin, a peptide that regulates iron absorption from diet and heme iron release by macrophages.	Iron	218-222	hepcidin antimicrobial peptide	Homo sapiens	183-191
21117319-3	2010	Mutations in hepcidin gene as well as in genes involved in hepcidin regulation lead to the toxic accumulation of iron in the body and exacerbate oxidative stress.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	13-21
21117319-3	2010	Mutations in hepcidin gene as well as in genes involved in hepcidin regulation lead to the toxic accumulation of iron in the body and exacerbate oxidative stress.	Iron	113-117	hepcidin antimicrobial peptide	Homo sapiens	59-67
20555217-0	2010	Adenovirus, MS2 and PhiX174 interactions with drinking water biofilms developed on PVC, cement and cast iron.	Iron	104-108	MS2	Homo sapiens	12-15
20039160-9	2009	Type 4 hemochromatosis follows an autosomal dominant trait; the corresponding mutation affects the basolateral iron carrier ferroportin 1.	Iron	111-115	solute carrier family 40 member 1	Homo sapiens	124-137
19998511-0	2009	Is iron overload in alcohol-related cirrhosis mediated by hepcidin?	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	58-66
19998511-5	2009	We suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefit in the future.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	36-44
19828835-0	2009	The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.	Iron	62-66	transferrin receptor 2	Homo sapiens	12-40
19996112-0	2009	Serum hepcidin: a novel diagnostic tool in disorders of iron metabolism.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	6-14
19776721-5	2009	Hepcidin is a central player in iron homeostasis.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	0-8
19776721-7	2009	In ESRD, plasma hepcidin levels are elevated, which contributes to iron deficiency in patients.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	16-24
19791753-5	2009	In contrast, a His87Cys mutant negates the ability of TZDs to affect the midpoint potential, suggesting a model of drug binding in which His87 is critical to communication with the FeS center of mitoNEET.	Iron	181-184	CDGSH iron sulfur domain 1	Homo sapiens	195-203
19740974-2	2009	OBJECTIVES: With the use of iron stable isotopes, we aimed to determine whether circulating hepcidin predicts dietary iron bioavailability, to quantify the amount of absorbed iron after oral iron loading, and to measure the plasma hepcidin response.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	92-100
19740974-6	2009	Plasma hepcidin significantly, but modestly, predicted iron bioavailability from ferrous sulfate and ferrous fumarate (r = -0.51 and -0.46, respectively; P &lt; 0.0001) but not from ferric pyrophosphate (r = -0.30, P = 0.056, respectively).	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	7-15
19740974-8	2009	CONCLUSIONS: Plasma hepcidin is only a modest predictor of dietary iron bioavailability in humans.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	20-28
19740974-9	2009	Oral iron loading, measured by stable-isotope appearance curves, increases circulating hepcidin.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	87-95
19625109-1	2009	In the last few years, biochemical and molecular study of the various types of hemochromatosis have established that the hepcidin peptide is the central regulator of iron absorption.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	121-129
19625109-4	2009	In hemochromatosis, there is a physical or functional hepcidin deficit that increases ferroportin, thus producing excessive iron absorption.	Iron	124-128	hepcidin antimicrobial peptide	Homo sapiens	54-62
19027283-0	2009	The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
19027283-0	2009	The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes.	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	45-58
19027283-4	2009	We provided evidence for the existence of iron exporter ferroportin 1 (Fpn1) in the heart in a recent study.	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	56-69
19027283-4	2009	We provided evidence for the existence of iron exporter ferroportin 1 (Fpn1) in the heart in a recent study.	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	71-75
19027283-6	2009	Based on these findings and the inhibiting role of hepcidin on Fpn1 in other tissues, we speculated that hepcidin might be able to bind with, internalize and degrade Fpn1 and then decrease iron export in heart cells, leading to an abnormal increase in heart iron and iron mediated cell injury.	Iron	189-193	hepcidin antimicrobial peptide	Homo sapiens	105-113
19027283-6	2009	Based on these findings and the inhibiting role of hepcidin on Fpn1 in other tissues, we speculated that hepcidin might be able to bind with, internalize and degrade Fpn1 and then decrease iron export in heart cells, leading to an abnormal increase in heart iron and iron mediated cell injury.	Iron	258-262	hepcidin antimicrobial peptide	Homo sapiens	105-113
19027283-6	2009	Based on these findings and the inhibiting role of hepcidin on Fpn1 in other tissues, we speculated that hepcidin might be able to bind with, internalize and degrade Fpn1 and then decrease iron export in heart cells, leading to an abnormal increase in heart iron and iron mediated cell injury.	Iron	258-262	hepcidin antimicrobial peptide	Homo sapiens	105-113
19027283-8	2009	We demonstrated that hepcidin has the ability to reduce Fpn1 content as well as iron release in this cell.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	21-29
19027283-9	2009	The similar regulation patterns of hepcidin on the Fpn1 and iron release suggested that the decreased iron release resulted from the decreased content of Fpn1 induced by hepcidin.	Iron	60-64	hepcidin antimicrobial peptide	Homo sapiens	35-43
19027283-9	2009	The similar regulation patterns of hepcidin on the Fpn1 and iron release suggested that the decreased iron release resulted from the decreased content of Fpn1 induced by hepcidin.	Iron	60-64	solute carrier family 40 member 1	Homo sapiens	154-158
19027283-9	2009	The similar regulation patterns of hepcidin on the Fpn1 and iron release suggested that the decreased iron release resulted from the decreased content of Fpn1 induced by hepcidin.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	35-43
19027283-9	2009	The similar regulation patterns of hepcidin on the Fpn1 and iron release suggested that the decreased iron release resulted from the decreased content of Fpn1 induced by hepcidin.	Iron	102-106	solute carrier family 40 member 1	Homo sapiens	154-158
19027283-9	2009	The similar regulation patterns of hepcidin on the Fpn1 and iron release suggested that the decreased iron release resulted from the decreased content of Fpn1 induced by hepcidin.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	170-178
19027283-11	2009	The data imply that Fpn1, rather than Heph and CP, is the limited factor in the regulation of iron release from heart cells under physiological conditions.	Iron	94-98	solute carrier family 40 member 1	Homo sapiens	20-24
19816198-3	2009	The recent discovery of mitochondrial ferritin (FtMt) provided the opportunity to identify a potential correlation between iron and mitochondrial function in RLS.	Iron	123-127	ferritin mitochondrial	Homo sapiens	24-46
19816198-3	2009	The recent discovery of mitochondrial ferritin (FtMt) provided the opportunity to identify a potential correlation between iron and mitochondrial function in RLS.	Iron	123-127	ferritin mitochondrial	Homo sapiens	48-52
19816198-9	2009	These results suggest that increased numbers of mitochondria in neurons in RLS and increased FtMt might contribute to insufficient cytosolic iron levels in RLS SN neurons; they are consistent with the hypothesis that energy insufficiency in these neurons may be involved in the pathogenesis of RLS.	Iron	141-145	ferritin mitochondrial	Homo sapiens	93-97
19816209-1	2009	Hepcidin is a regulatory peptide hormone acts by limiting intestinal iron absorption and promoting iron retention.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	0-8
19816209-1	2009	Hepcidin is a regulatory peptide hormone acts by limiting intestinal iron absorption and promoting iron retention.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	0-8
19816209-2	2009	Determining the level of hepcidin in anemia of prematurity might be important in preventing iron overload.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	25-33
19752196-7	2009	By a novel radiolabeling technique, the amount of iron associated with complex I was also shown to reflect the dependence of this enzyme on huInd1 for assembly.	Iron	50-54	NUBP iron-sulfur cluster assembly factor, mitochondrial	Homo sapiens	140-146
19752196-8	2009	Together, these data identify huInd1 as a new assembly factor for human respiratory complex I with a possible role in the delivery of one or more Fe/S clusters to complex I subunits.	Iron	146-148	NUBP iron-sulfur cluster assembly factor, mitochondrial	Homo sapiens	30-36
19762596-3	2009	We found that a SKP1-CUL1-FBXL5 ubiquitin ligase protein complex associates with and promotes the iron-dependent ubiquitination and degradation of IRP2.	Iron	98-102	S-phase kinase associated protein 1	Homo sapiens	16-20
21415988-6	2009	In particular, the data presented indicate the inextricably link between erythropoiesis and iron metabolism and the key role of hepcidin in coordinating iron procurement according to erythropoietic requirement.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	128-136
21415988-7	2009	The role of erythropoietin, hypoxia, erythroid-dependent soluble factors and iron in regulating hepcidin transcription are discussed as well as differences and similarities in iron homeostasis between thalassemia syndromes and sickle cell disease.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	96-104
19825182-3	2009	DOHH activity is inhibited by two clinically used drugs, the topical fungicide ciclopirox and the systemic medicinal iron chelator deferiprone.	Iron	117-121	deoxyhypusine hydroxylase	Homo sapiens	0-4
19787824-5	2009	Hepcidin, which is made primarily in hepatocytes in response to liver iron levels, inflammation, hypoxia and anemia, is the main iron regulatory hormone.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-8
19787824-7	2009	Thus, in chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD + ID).	Iron	64-68	hepcidin antimicrobial peptide	Homo sapiens	45-53
19787824-7	2009	Thus, in chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD + ID).	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	45-53
19787824-7	2009	Thus, in chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD + ID).	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	45-53
19787824-7	2009	Thus, in chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD + ID).	Iron	93-97	hepcidin antimicrobial peptide	Homo sapiens	45-53
19787824-8	2009	In contrast, low hepcidin expression may lead to iron overload, and vice versa.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	17-25
19645734-6	2009	For example, plasminogen activator inhibitor 1 was shown to play a central role for steatosis, the anti-inflammatory adipokine, adiponectin profoundly regulates liver macrophage function and excessive hepatic deposition of iron is caused by chronic ethanol intoxication and increases the risk of hepatocellular carcinoma development.	Iron	223-227	serpin family E member 1	Homo sapiens	13-46
19808016-2	2009	Two recent papers (Oliveira et al., 2009; Vecchi et al., 2009) show that the UPR modulates transcription of the hormone hepcidin, which controls plasma iron levels and perhaps innate immunity.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	120-128
19874266-2	2009	Heme oxygenase-1 (HO-1) is a 32 kDa stress protein that catabolizes heme to biliverdin, free iron and carbon monoxide.	Iron	93-97	heme oxygenase 1	Homo sapiens	0-16
19874266-2	2009	Heme oxygenase-1 (HO-1) is a 32 kDa stress protein that catabolizes heme to biliverdin, free iron and carbon monoxide.	Iron	93-97	heme oxygenase 1	Homo sapiens	18-22
19467259-1	2009	Transferrin (Tf) is a multifunctional, iron binding protein found in both vertebrates and invertebrates.	Iron	39-43	transferrin	Bombyx mori	0-11
19467259-1	2009	Transferrin (Tf) is a multifunctional, iron binding protein found in both vertebrates and invertebrates.	Iron	39-43	transferrin	Bombyx mori	13-15
19467259-6	2009	Recombinant BmTf protein produced in a baculovirus system exhibits iron binding capacity and antibacterial activity against various Gram-positive and -negative bacteria.	Iron	67-71	transferrin	Bombyx mori	12-16
19671018-7	2009	Ethanol, polyunsaturated fatty acids and iron were toxic to the HepG2 cells, which express CYP2E1 (E47 cells) but not control C34HepG2 cells, which do not express CYP2E1.	Iron	41-45	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	163-169
19591830-2	2009	Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating that HFE regulates hepcidin.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	184-192
19591830-8	2009	RESULTS: Liver levels of Bmp6 messenger RNA (mRNA) were higher in Hfe KO mice; these were appropriate for the increased hepatic levels of iron in these mice, compared with WT mice.	Iron	138-142	bone morphogenetic protein 6	Mus musculus	25-29
19591830-11	2009	CONCLUSIONS: HFE is not involved in regulation of BMP6 by iron, but does regulate the downstream signals of BMP6 that are triggered by iron.	Iron	135-139	bone morphogenetic protein 6	Mus musculus	108-112
19387685-5	2009	Hepcidin was markedly decreased in HCC but still correlated with hepatic iron stores.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
19620254-12	2009	Thus, resveratrol protects cells from AA + iron-induced ROS production and mitochondrial dysfunction through AMPK-mediated inhibitory phosphorylation of GSK3beta downstream of poly(ADP-ribose)polymerase-LKB1 pathway.	Iron	43-47	serine/threonine kinase 11	Homo sapiens	203-207
19786201-2	2009	In particular, the discovery of hepcidin and its fundamental role as the hormonal peptide regulating iron metabolism has delineated the organization of the complex network of proteins that regulates iron metabolism within the body.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	32-40
19786201-2	2009	In particular, the discovery of hepcidin and its fundamental role as the hormonal peptide regulating iron metabolism has delineated the organization of the complex network of proteins that regulates iron metabolism within the body.	Iron	199-203	hepcidin antimicrobial peptide	Homo sapiens	32-40
19786204-1	2009	Divalent metal transporter 1 (DMT1) is the protein that allows elemental iron entry into the duodenal cell.	Iron	73-77	solute carrier family 11 member 2	Homo sapiens	0-28
19786204-1	2009	Divalent metal transporter 1 (DMT1) is the protein that allows elemental iron entry into the duodenal cell.	Iron	73-77	solute carrier family 11 member 2	Homo sapiens	30-34
19786204-12	2009	In this review we analyze the role of DMT1 in iron metabolism and the major causes of reduction and their consequences in animal models as well in humans, and we attempt to define the correct treatment for human mutants.	Iron	46-50	solute carrier family 11 member 2	Homo sapiens	38-42
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	157-161	ATP binding cassette subfamily B member 7	Homo sapiens	93-98
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	157-161	glutaredoxin 5	Homo sapiens	104-118
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	157-161	glutaredoxin 5	Homo sapiens	120-125
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	280-284	ATP binding cassette subfamily B member 7	Homo sapiens	93-98
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	280-284	glutaredoxin 5	Homo sapiens	104-118
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	280-284	glutaredoxin 5	Homo sapiens	120-125
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	280-284	ATP binding cassette subfamily B member 7	Homo sapiens	93-98
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	280-284	glutaredoxin 5	Homo sapiens	104-118
19786205-4	2009	The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs).	Iron	280-284	glutaredoxin 5	Homo sapiens	120-125
19786206-3	2009	IRIDA patients show inappropriately elevated levels of hepcidin, a circulating hormone produced by the liver that inhibits both iron absorption from the intestine and iron release from macrophage stores.	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	55-63
19786206-3	2009	IRIDA patients show inappropriately elevated levels of hepcidin, a circulating hormone produced by the liver that inhibits both iron absorption from the intestine and iron release from macrophage stores.	Iron	167-171	hepcidin antimicrobial peptide	Homo sapiens	55-63
19786207-2	2009	During the last decade, the molecular mechanisms of iron sequestration have been found to center on cytokine-stimulated overproduction of the iron-regulatory hormone hepcidin.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	166-174
19786207-4	2009	Hepcidin excess causes the endocytosis and proteolysis of the sole known cellular iron exporter, ferroportin, trapping iron in macrophages and iron-absorbing enterocytes.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
19786207-4	2009	Hepcidin excess causes the endocytosis and proteolysis of the sole known cellular iron exporter, ferroportin, trapping iron in macrophages and iron-absorbing enterocytes.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	0-8
19786207-4	2009	Hepcidin excess causes the endocytosis and proteolysis of the sole known cellular iron exporter, ferroportin, trapping iron in macrophages and iron-absorbing enterocytes.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	0-8
19682329-2	2009	In keeping with its proposed role in iron sensing, previous studies showed that TfR2 has a short half-life and that holo-Tf stabilizes TfR2 by redirecting it from a degradative pathway to a recycling pathway.	Iron	37-41	transferrin receptor 2	Homo sapiens	80-84
19694439-2	2009	In humans, heme oxygenase-1 (hHO-1) is overexpressed in tumor tissues, where it helps to protect cancer cells from anticancer agents, while HOs in fungal pathogens, such as Candida albicans, function as the primary means of iron acquisition.	Iron	224-228	heme oxygenase 1	Homo sapiens	11-27
19694439-2	2009	In humans, heme oxygenase-1 (hHO-1) is overexpressed in tumor tissues, where it helps to protect cancer cells from anticancer agents, while HOs in fungal pathogens, such as Candida albicans, function as the primary means of iron acquisition.	Iron	224-228	heme oxygenase 1	Homo sapiens	29-34
19553145-0	2009	Not all DMT1 mutations lead to iron overload.	Iron	31-35	solute carrier family 11 member 2	Homo sapiens	8-12
19553145-2	2009	Results from animal models and from patients have shown that DMT1 is required for intestinal iron absorption and iron acquisition by erythrocytes.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	61-65
19553145-2	2009	Results from animal models and from patients have shown that DMT1 is required for intestinal iron absorption and iron acquisition by erythrocytes.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	61-65
19571663-5	2009	Importantly, one of the HH genes, HAMP, encodes the master regulator of iron homeostasis, hepcidin, which is expressed by hepatocytes.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	34-38
19571663-5	2009	Importantly, one of the HH genes, HAMP, encodes the master regulator of iron homeostasis, hepcidin, which is expressed by hepatocytes.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	90-98
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Iron	133-137	complement C4A (Rodgers blood group)	Homo sapiens	351-354
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Iron	133-137	complement C5	Homo sapiens	359-362
19664057-10	2009	These findings are consistent with the hypothesis that gastrin peptides bind to nonligand residues within the open cleft in each lobe of transferrin and are involved in iron loading of transferrin in vivo.	Iron	169-173	gastrin	Homo sapiens	55-62
19734411-0	2009	Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	21-29
19734422-0	2009	Association of hepcidin promoter c.-582 A&gt;G variant and iron overload in thalassemia major.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	15-23
19734422-3	2009	Moreover, as demonstrated in mice and humans, hepcidin is a major regulator of iron metabolism, and acts by binding to ferroportin and controlling its concentration and trafficking.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	46-54
19734422-4	2009	In this study we investigated the influence that mutations in HAMP and/or hemocromatosis (HFE) genes might exert on iron metabolism in a group of poly-transfused thalassemic patients in preparation for bone marrow transplantation.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	62-66
19734422-5	2009	Our results showed that the presence of the c.-582 A&gt;G polymorphism (rs10421768) placed in HAMP promoter (HAMP-P) might play a role in iron metabolism, perhaps varying the transcriptional activation that occurs through E-boxes located within the promoter.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	94-98
19734422-5	2009	Our results showed that the presence of the c.-582 A&gt;G polymorphism (rs10421768) placed in HAMP promoter (HAMP-P) might play a role in iron metabolism, perhaps varying the transcriptional activation that occurs through E-boxes located within the promoter.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	109-113
18774956-1	2009	Heme oxygenase-1 (HO-1) contribution to iron homeostasis has been postulated, because it facilitates iron recycling by liberating iron mostly from heme catabolism.	Iron	40-44	heme oxygenase 1	Homo sapiens	0-16
18774956-1	2009	Heme oxygenase-1 (HO-1) contribution to iron homeostasis has been postulated, because it facilitates iron recycling by liberating iron mostly from heme catabolism.	Iron	40-44	heme oxygenase 1	Homo sapiens	18-22
18774956-1	2009	Heme oxygenase-1 (HO-1) contribution to iron homeostasis has been postulated, because it facilitates iron recycling by liberating iron mostly from heme catabolism.	Iron	101-105	heme oxygenase 1	Homo sapiens	0-16
18774956-1	2009	Heme oxygenase-1 (HO-1) contribution to iron homeostasis has been postulated, because it facilitates iron recycling by liberating iron mostly from heme catabolism.	Iron	101-105	heme oxygenase 1	Homo sapiens	18-22
18774956-1	2009	Heme oxygenase-1 (HO-1) contribution to iron homeostasis has been postulated, because it facilitates iron recycling by liberating iron mostly from heme catabolism.	Iron	101-105	heme oxygenase 1	Homo sapiens	0-16
18774956-1	2009	Heme oxygenase-1 (HO-1) contribution to iron homeostasis has been postulated, because it facilitates iron recycling by liberating iron mostly from heme catabolism.	Iron	101-105	heme oxygenase 1	Homo sapiens	18-22
18774956-4	2009	Here we postulated that HO-1 is critical in the regulation of ferroportin, the major cellular iron exporter, and hepcidin, the key regulator of iron homeostasis central in the pathogenesis of anemia of inflammation.	Iron	94-98	heme oxygenase 1	Homo sapiens	24-28
18774956-4	2009	Here we postulated that HO-1 is critical in the regulation of ferroportin, the major cellular iron exporter, and hepcidin, the key regulator of iron homeostasis central in the pathogenesis of anemia of inflammation.	Iron	144-148	heme oxygenase 1	Homo sapiens	24-28
18774956-4	2009	Here we postulated that HO-1 is critical in the regulation of ferroportin, the major cellular iron exporter, and hepcidin, the key regulator of iron homeostasis central in the pathogenesis of anemia of inflammation.	Iron	144-148	hepcidin antimicrobial peptide	Homo sapiens	113-121
18774956-5	2009	Our current experiments in human THP-1 monocytic cells indicate a HO-1-induced iron-mediated surface-ferroportin expression, consistent with the role of HO-1 in iron recycling.	Iron	79-83	heme oxygenase 1	Homo sapiens	66-70
18774956-5	2009	Our current experiments in human THP-1 monocytic cells indicate a HO-1-induced iron-mediated surface-ferroportin expression, consistent with the role of HO-1 in iron recycling.	Iron	79-83	heme oxygenase 1	Homo sapiens	153-157
18774956-5	2009	Our current experiments in human THP-1 monocytic cells indicate a HO-1-induced iron-mediated surface-ferroportin expression, consistent with the role of HO-1 in iron recycling.	Iron	161-165	heme oxygenase 1	Homo sapiens	66-70
18774956-5	2009	Our current experiments in human THP-1 monocytic cells indicate a HO-1-induced iron-mediated surface-ferroportin expression, consistent with the role of HO-1 in iron recycling.	Iron	161-165	heme oxygenase 1	Homo sapiens	153-157
18774956-8	2009	This suggests that the decreased hepcidin levels in HO-1 deficiency reflect the increased need for iron in the bone marrow due to the anaemia.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	33-41
18774956-10	2009	Therefore, we argue that the decreased iron recycling may, in part, have contributed to the low hepcidin levels.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	96-104
18774956-11	2009	These findings indicate that dysregulation of iron homeostasis in HO-1 deficiency is the result of both defective iron recycling and erythroid activity-associated inhibition of hepcidin expression.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	177-185
18774956-12	2009	This study therefore shows a crucial role for HO-1 in maintaining body iron balance.	Iron	71-75	heme oxygenase 1	Homo sapiens	46-50
19722697-1	2009	Human NFU (also known as HIRIP5) has been implicated in cellular iron-sulfur cluster biosynthesis.	Iron	65-69	NFU1 iron-sulfur cluster scaffold	Homo sapiens	25-31
19271990-0	2009	Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism.	Iron	85-89	ferritin mitochondrial	Homo sapiens	18-40
19500086-1	2009	The hepatic peptide hormone hepcidin plays a central role in body iron metabolism.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	28-36
19656490-4	2009	We identified SLC25A39, SLC22A4, and TMEM14C, which are putative mitochondrial transporters, as well as C1orf69 and ISCA1, which are iron-sulfur cluster proteins.	Iron	133-137	iron-sulfur cluster assembly 1	Mus musculus	116-121
19325037-4	2009	Initially, we showed that only aggregated alpha-synuclein is neurotoxic and requires the presence copper but not iron.	Iron	113-117	synuclein alpha	Homo sapiens	42-57
19678841-2	2009	Disruption of the Atx1-Ccc2 route leads to cell growth arrest in a copper-and-iron-limited medium, a phenotype allowing complementation studies.	Iron	78-82	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	18-22
19788062-9	2009	Based on these results, a two-transporter model of iron uptake, comprising the apical iron uptake transporter divalent metal ion transporter-1 (DMT-1) and an unknown putative transporter was derived.	Iron	51-55	solute carrier family 11 member 2	Homo sapiens	110-142
19788062-9	2009	Based on these results, a two-transporter model of iron uptake, comprising the apical iron uptake transporter divalent metal ion transporter-1 (DMT-1) and an unknown putative transporter was derived.	Iron	51-55	solute carrier family 11 member 2	Homo sapiens	144-149
19788062-9	2009	Based on these results, a two-transporter model of iron uptake, comprising the apical iron uptake transporter divalent metal ion transporter-1 (DMT-1) and an unknown putative transporter was derived.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	110-142
19788062-9	2009	Based on these results, a two-transporter model of iron uptake, comprising the apical iron uptake transporter divalent metal ion transporter-1 (DMT-1) and an unknown putative transporter was derived.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	144-149
19788062-12	2009	DMT-1 might not simultaneously transport iron and zinc, providing a mechanistic basis for observed interactions.	Iron	41-45	solute carrier family 11 member 2	Homo sapiens	0-5
19492851-0	2009	Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB.	Iron	30-34	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	122-126
19559399-1	2009	FTO is a nuclear protein belonging to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent dioxygenase family.	Iron	64-68	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	0-3
19166904-0	2009	Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.	Iron	76-80	synuclein alpha	Homo sapiens	30-45
19169653-0	2009	Iron-dependent oxidative inactivation with affinity cleavage of pyruvate kinase.	Iron	0-4	pyruvate kinase PKLR	Oryctolagus cuniculus	64-79
19169653-1	2009	Treatment of rabbit muscle pyruvate kinase with iron/ascorbate caused an inactivation with the cleavage of peptide bond.	Iron	48-52	pyruvate kinase PKLR	Oryctolagus cuniculus	27-42
19169653-7	2009	Iron-dependent oxidative inactivation/fragmentation of pyruvate kinase can explain the decreased glycolytic flux under aerobic conditions.	Iron	0-4	pyruvate kinase PKLR	Oryctolagus cuniculus	55-70
19444865-4	2009	In NAFLD, a moderate liver iron accumulation has been observed and molecular mechanisms, including the downregulation of the liver iron exporter ferroportin-1, have been described.	Iron	131-135	solute carrier family 40 member 1	Homo sapiens	145-158
19374902-12	2009	Collectively, these results establish that iron accumulates after intraspinal TLR4 activation and is required for maximal TLR4-induced oligodendrogenesis.	Iron	43-47	toll like receptor 4	Homo sapiens	78-82
19374902-12	2009	Collectively, these results establish that iron accumulates after intraspinal TLR4 activation and is required for maximal TLR4-induced oligodendrogenesis.	Iron	43-47	toll like receptor 4	Homo sapiens	122-126
19374902-13	2009	Since TLR4 agonists are abundant in CNS injury/disease sites, these results suggest that iron may be essential for macrophage/oligodendrocyte communication and adult glial replacement.	Iron	89-93	toll like receptor 4	Homo sapiens	6-10
19798981-0	2009	[Study on interaction between heme-iron of myoglobin and metal ions by visible spectroscopy (I)].	Iron	35-39	myoglobin	Homo sapiens	43-52
19798981-3	2009	In the present paper, the direct interaction between heme-iron of myoglobin and additional metal ions [Cu (II), Zn (II) and Co( II)] was studied by UV-Vis spectra.	Iron	58-62	myoglobin	Homo sapiens	66-75
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	23-27	myoglobin	Homo sapiens	31-40
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	23-27	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	23-27	myoglobin	Homo sapiens	175-184
19760959-11	2009	Our results suggest that CHC may induce the expression of hepcidin possibly by increased hepatic iron stores.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	58-66
19457084-3	2009	Heme oxygenase-1 (HO-1), an enzyme that converts heme to free iron, carbon monoxide (CO) and biliverdin (bilirubin precursor) is expressed in response to various stressors.	Iron	62-66	heme oxygenase 1	Homo sapiens	0-16
19457084-3	2009	Heme oxygenase-1 (HO-1), an enzyme that converts heme to free iron, carbon monoxide (CO) and biliverdin (bilirubin precursor) is expressed in response to various stressors.	Iron	62-66	heme oxygenase 1	Homo sapiens	18-22
19457084-7	2009	Likewise, treatment of HO-1 over-expressing cells with the HO-1 inhibitor, tin mesoporphyrin, the iron chelator deferoxamine or antagonist of CO-dependent cGMP activation, methylene blue, mitigated the HO-1-induced reduction in alpha-synuclein levels.	Iron	98-102	heme oxygenase 1	Homo sapiens	23-27
19715836-1	2009	Hepcidin is a hormone that regulates the intestinal absorption of iron and its release from the reticuloendothelium.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
19388667-5	2009	Comparison of mitoNEET to its ferredoxin-like H87C mutant indicates that Raman peaks in the approximately 250-300 cm(-1) region of mitoNEET are influenced by the Fe-His87 moiety.	Iron	162-164	CDGSH iron sulfur domain 1	Homo sapiens	14-22
19388667-5	2009	Comparison of mitoNEET to its ferredoxin-like H87C mutant indicates that Raman peaks in the approximately 250-300 cm(-1) region of mitoNEET are influenced by the Fe-His87 moiety.	Iron	162-164	CDGSH iron sulfur domain 1	Homo sapiens	131-139
19388667-9	2009	These results support the hypothesis that the Fe-N(His87) interaction is modulated within the physiological pH range, and this modulation may be critical to the function of mitoNEET.	Iron	46-50	CDGSH iron sulfur domain 1	Homo sapiens	173-181
19384939-9	2009	Subsequent quantitative PCR experiments validated 12 candidate genes; with GSTM1, eIF5a, SULF2, NTS, and HO-1 being particularly good prospects as genes that might affect the degree of iron accumulation.	Iron	185-189	eukaryotic translation initiation factor 5A	Homo sapiens	82-87
19384939-9	2009	Subsequent quantitative PCR experiments validated 12 candidate genes; with GSTM1, eIF5a, SULF2, NTS, and HO-1 being particularly good prospects as genes that might affect the degree of iron accumulation.	Iron	185-189	sulfatase 2	Homo sapiens	89-94
19442249-0	2009	Structure, function and evolution of the XPD family of iron-sulfur-containing 5"--&gt;3" DNA helicases.	Iron	55-59	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	41-44
19442249-6	2009	Crystal structures of XPD from three archaeal organisms reveal a four-domain structure with two canonical motor domains and two unique domains, termed the Arch and iron-sulfur-cluster-binding domains.	Iron	164-168	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	22-25
19502737-2	2009	The hydrolysates of rhLF and hLF were found to be more active than native proteins against E. coli O157:H7, and their activity was independent of their iron saturation.	Iron	152-156	HLF transcription factor, PAR bZIP family member	Homo sapiens	21-24
19260996-6	2009	CONCLUSIONS: Although the hepcidin expression responds to iron conditions in C-HCV, this response is relatively limited.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	26-34
19260996-7	2009	This relative impairment of hepcidin expression may be relevant to disease progression, and thus correction of its regulation may be beneficial for these iron-overloaded C-HCV patients.	Iron	154-158	hepcidin antimicrobial peptide	Homo sapiens	28-36
19398238-0	2009	Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	105-113
19398238-5	2009	There was an inverse correlation between intestinal iron absorption and plasma hepcidin (r = -0.61, p &lt; 0.001), HOMA (r = -0.35, p = 0.01) and C reactive protein (r = -0.52, p &lt; 0.001).	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	79-87
19398238-6	2009	CONCLUSIONS: In overweight subjects with normal iron stores, iron absorption is decreased through hepcidin upregulation.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	98-106
19398238-7	2009	In patients with DIOS, this decrease is more pronounced due to an additional effect of iron excess on circulating hepcidin levels.	Iron	87-91	hepcidin antimicrobial peptide	Homo sapiens	114-122
19250966-0	2009	A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson"s disease.	Iron	48-52	transferrin receptor 2	Homo sapiens	20-24
19250966-3	2009	Here, we report a novel transferrin/transferrin receptor 2 (Tf/TfR2)-mediated iron transport pathway in mitochondria of SN dopamine neurons.	Iron	78-82	coagulation factor III, tissue factor	Homo sapiens	60-62
19250966-3	2009	Here, we report a novel transferrin/transferrin receptor 2 (Tf/TfR2)-mediated iron transport pathway in mitochondria of SN dopamine neurons.	Iron	78-82	transferrin receptor 2	Homo sapiens	63-67
19250966-5	2009	Importantly, the Tf/TfR2 pathway can deliver Tf bound iron to mitochondria and to the respiratory complex I as well.	Iron	54-58	coagulation factor III, tissue factor	Homo sapiens	17-19
19250966-5	2009	Importantly, the Tf/TfR2 pathway can deliver Tf bound iron to mitochondria and to the respiratory complex I as well.	Iron	54-58	transferrin receptor 2	Homo sapiens	20-24
19250966-5	2009	Importantly, the Tf/TfR2 pathway can deliver Tf bound iron to mitochondria and to the respiratory complex I as well.	Iron	54-58	coagulation factor III, tissue factor	Homo sapiens	20-22
20596327-5	2009	The arrays of CdS nanotube with thin wall exhibit better FE properties, a lower turn-on field, and a higher field enhancement factor than that of the arrays of CdS nanotube with thick wall, for which the ratio of length to the wall thickness of the CdS nanotubes have played an important role.	Iron	57-59	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
19357222-0	2009	Soybean ferritin: implications for iron status of vegetarians.	Iron	35-39	ferritin-1, chloroplastic	Glycine max	8-16
19357222-3	2009	Because each ferritin molecule can bind to thousands of iron atoms, this may be a sustainable means to increase the iron contents of plants.	Iron	56-60	ferritin-1, chloroplastic	Glycine max	13-21
19357222-3	2009	Because each ferritin molecule can bind to thousands of iron atoms, this may be a sustainable means to increase the iron contents of plants.	Iron	116-120	ferritin-1, chloroplastic	Glycine max	13-21
19357222-4	2009	Before such efforts are launched, it is important to determine whether iron in ferritin is bioavailable.	Iron	71-75	ferritin-1, chloroplastic	Glycine max	79-87
19357222-6	2009	Dietary factors affecting iron absorption, eg, ascorbic acid, phytate, and calcium, had limited effect on iron uptake from intact ferritin by Caco-2 cells, which suggests that ferritin-bound iron is absorbed via a mechanism different from that of nonheme iron.	Iron	26-30	ferritin-1, chloroplastic	Glycine max	176-184
19357222-9	2009	In human subjects, iron from purified soybean ferritin given in a meal was as well absorbed as iron from ferrous sulfate.	Iron	19-23	ferritin-1, chloroplastic	Glycine max	46-54
19357222-10	2009	In conclusion, iron is well absorbed from ferritin and may represent a means of biofortification of staple foods such as soybeans.	Iron	15-19	ferritin-1, chloroplastic	Glycine max	42-50
19251588-10	2009	CONCLUSIONS: Our data indicate that prolonged exposure to LPS or iron increases endothelial NADPH oxidase activity by increasing p22phox gene transcription and cellular levels of iron, heme, and p22phox protein.	Iron	65-69	cytochrome b-245 alpha chain	Homo sapiens	129-136
19251588-10	2009	CONCLUSIONS: Our data indicate that prolonged exposure to LPS or iron increases endothelial NADPH oxidase activity by increasing p22phox gene transcription and cellular levels of iron, heme, and p22phox protein.	Iron	65-69	cytochrome b-245 alpha chain	Homo sapiens	195-202
19326097-5	2009	Real-time quantitative PCR analysis indicates that vva0331 gene expression is activated at 30 degrees C and regulated by iron.	Iron	121-125	BJE04_RS17365	Vibrio vulnificus YJ016	51-58
19352007-0	2009	HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.	Iron	41-45	endothelial PAS domain protein 1	Mus musculus	0-10
19352007-5	2009	Using these mice, we found that HIF-1alpha was not necessary for iron absorption, whereas HIF-2alpha played a crucial role in maintaining iron balance in the organism by directly regulating the transcription of the gene encoding divalent metal transporter 1 (DMT1), the principal intestinal iron transporter.	Iron	138-142	endothelial PAS domain protein 1	Mus musculus	90-100
19352007-6	2009	Specific deletion of Hif2a led to a decrease in serum and liver iron levels and a marked decrease in liver hepcidin expression, indicating the involvement of an induced systemic response to counteract the iron deficiency.	Iron	64-68	endothelial PAS domain protein 1	Mus musculus	21-26
19352007-7	2009	This finding may provide a basis for the development of new strategies, specifically in targeting HIF-2alpha, to improve iron homeostasis in patients with iron disorders.	Iron	121-125	endothelial PAS domain protein 1	Homo sapiens	98-108
19250338-0	2009	HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues.	Iron	58-62	heme oxygenase 1	Homo sapiens	0-4
19250338-2	2009	We previously demonstrated that heme oxygenase-1 (HO-1) is up-regulated in AD and PD brain and promotes the accumulation of non-transferrin iron in astroglial mitochondria.	Iron	140-144	heme oxygenase 1	Homo sapiens	32-48
19250338-2	2009	We previously demonstrated that heme oxygenase-1 (HO-1) is up-regulated in AD and PD brain and promotes the accumulation of non-transferrin iron in astroglial mitochondria.	Iron	140-144	heme oxygenase 1	Homo sapiens	50-54
19250338-5	2009	HO-1 promoted trapping of redox-active iron and sulfur within many cytopathological profiles without impacting ferroportin, transferrin receptor, ferritin, and IRP2 protein levels or IRP1 activity.	Iron	39-43	heme oxygenase 1	Homo sapiens	0-4
19258043-1	2009	INTRODUCTION: Hepcidin, a 25-amino acid peptide hormone, plays a crucial regulatory role in iron metabolism.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	14-22
19415084-6	2009	Hepcidin production is up-regulated in iron overload and down-regulated with iron deficiency.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	0-8
19415084-11	2009	Hepcidin is currently considered to be the &lt;&lt;key regulator&gt;&gt; of the iron balance.	Iron	80-84	hepcidin antimicrobial peptide	Homo sapiens	0-8
19317403-4	2009	In this Article, we report on the detailed processes of accumulation of Pd(II) ions demonstrated by a series of X-ray crystal structural analyses of apo-ferritin (apo-Fr), an iron storage protein, containing different amounts of Pd(II) ions in the protein cage.	Iron	175-179	ferritin heavy chain 1	Homo sapiens	149-161
19070948-11	2009	The 2.78-kDa protein was identified as the active 25-amino acid form of hepcidin (hepcidin-25), a key regulator of iron homeostasis.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	72-80
19070948-11	2009	The 2.78-kDa protein was identified as the active 25-amino acid form of hepcidin (hepcidin-25), a key regulator of iron homeostasis.	Iron	115-119	hepcidin antimicrobial peptide	Homo sapiens	82-90
19070948-18	2009	The enhancement of hepcidin-25 in patients without AKI may suggest a novel role for iron sequestration in modulating AKI.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	19-27
19179627-1	2009	Divalent metal transporter-1 (DMT1) is a divalent cation transporter that plays a key role in iron metabolism by mediating ferrous iron uptake across the small intestine.	Iron	94-98	solute carrier family 11 member 2	Homo sapiens	0-28
19179627-1	2009	Divalent metal transporter-1 (DMT1) is a divalent cation transporter that plays a key role in iron metabolism by mediating ferrous iron uptake across the small intestine.	Iron	94-98	solute carrier family 11 member 2	Homo sapiens	30-34
19179627-1	2009	Divalent metal transporter-1 (DMT1) is a divalent cation transporter that plays a key role in iron metabolism by mediating ferrous iron uptake across the small intestine.	Iron	123-135	solute carrier family 11 member 2	Homo sapiens	0-28
19179627-1	2009	Divalent metal transporter-1 (DMT1) is a divalent cation transporter that plays a key role in iron metabolism by mediating ferrous iron uptake across the small intestine.	Iron	123-135	solute carrier family 11 member 2	Homo sapiens	30-34
19179627-4	2009	One compound, NSC306711, inhibited DMT1-mediated iron uptake in a reversible and competitive manner.	Iron	49-53	solute carrier family 11 member 2	Homo sapiens	35-39
19179627-8	2009	This study characterizes important pharmacological tools that can be used to probe DMT1"s mechanism of iron transport and its role in iron metabolism.	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	83-87
19179627-8	2009	This study characterizes important pharmacological tools that can be used to probe DMT1"s mechanism of iron transport and its role in iron metabolism.	Iron	134-138	solute carrier family 11 member 2	Homo sapiens	83-87
19152828-5	2009	Hepcidin is a hormone synthesized in the liver which is mainly responsible for an inhibition of iron absorption in the small intestine during an inflammatory process.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	0-8
19171677-3	2009	Cyclic voltammetry demonstrated direct electrochemistry of the CYP2C9 enzyme bonded to the electrode and fast electron transfer between the heme iron and the gold electrode.	Iron	145-149	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	63-69
19304112-6	2009	Recently, several new proteins have been described that play critical roles in iron regulation including the master regulator of iron metabolism (hepcidin).	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	146-154
19304112-6	2009	Recently, several new proteins have been described that play critical roles in iron regulation including the master regulator of iron metabolism (hepcidin).	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	146-154
19233066-4	2009	This review focuses on the mechanisms by which inflammation interferes with erythroid marrow function and particularly the new information about the role of inflammatory cytokines and the small peptide, hepcidin, on altered iron metabolism.	Iron	224-228	hepcidin antimicrobial peptide	Homo sapiens	203-211
19528880-1	2009	PURPOSE OF REVIEW: Intestinal iron absorption is an essential physiological process that is regulated by the liver-derived peptide hepcidin.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	131-139
19528880-3	2009	RECENT FINDINGS: Hepcidin acts as a repressor of iron absorption and its expression in turn reflects a range of systemic cues, including iron status, hypoxia, erythropoiesis and inflammation.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	17-25
19528880-3	2009	RECENT FINDINGS: Hepcidin acts as a repressor of iron absorption and its expression in turn reflects a range of systemic cues, including iron status, hypoxia, erythropoiesis and inflammation.	Iron	137-141	hepcidin antimicrobial peptide	Homo sapiens	17-25
19528880-6	2009	At the enterocyte itself, the recent demonstration of a chaperone for delivering iron to ferritin and new data on iron release from the hepcidin target ferroportin are helping to define the pathway of iron movement across the intestinal epithelium.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	136-144
19528880-6	2009	At the enterocyte itself, the recent demonstration of a chaperone for delivering iron to ferritin and new data on iron release from the hepcidin target ferroportin are helping to define the pathway of iron movement across the intestinal epithelium.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	136-144
19528880-7	2009	SUMMARY: Disturbances in the hepcidin regulatory pathway underlie a range of iron metabolism disorders, from iron deficiency to iron loading, and there is considerable promise that the exciting recent advances in understanding hepcidin action will be translated into improved diagnostic and therapeutic modalities in the near future.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	29-37
19528880-7	2009	SUMMARY: Disturbances in the hepcidin regulatory pathway underlie a range of iron metabolism disorders, from iron deficiency to iron loading, and there is considerable promise that the exciting recent advances in understanding hepcidin action will be translated into improved diagnostic and therapeutic modalities in the near future.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	227-235
19101095-3	2009	This study was designed to compare the biological effects of X-rays and of high-linear energy transfer (LET) (56)Fe ions on human mesenchymal stem cells (hMSC).	Iron	113-115	musculin	Homo sapiens	154-158
19101095-4	2009	METHODS AND MATERIALS: A multi-functional comparison was carried out to investigate the differential effects of X-rays and (56)Fe ions on hMSC.	Iron	127-129	musculin	Homo sapiens	138-142
19101095-6	2009	RESULTS: X-rays and (56)Fe ions differentially inhibited the cell cycle progression of hMSC in a p53-dependent manner without impairing their in vitro osteogenic differentiation process.	Iron	24-26	musculin	Homo sapiens	87-91
19101095-10	2009	CONCLUSIONS: (56)Fe ions exert more significant effects on hMSC than X-rays.	Iron	17-19	musculin	Homo sapiens	59-63
19240331-3	2009	Here, UV-Vis microspectrophotometry is used to test the efficacy of selected scavengers in reducing the undesirable photoreduction of the iron and copper centres in myoglobin and azurin, respectively, and X-ray crystallography to assess their capacity of mitigating global and specific radiation damage effects.	Iron	138-142	myoglobin	Homo sapiens	165-174
19228364-9	2009	CONCLUSION: Changes in hepcidin and transferrin receptor gene expression were consistent with the known biology of iron metabolism.	Iron	115-119	hepcidin antimicrobial peptide	Canis lupus familiaris	23-31
19228364-9	2009	CONCLUSION: Changes in hepcidin and transferrin receptor gene expression were consistent with the known biology of iron metabolism.	Iron	115-119	inhibitor of carbonic anhydrase	Canis lupus familiaris	36-47
19029439-1	2009	Hemojuvelin (HJV) was recently identified as a critical regulator of iron homeostasis.	Iron	69-73	hemojuvelin BMP co-receptor	Homo sapiens	0-11
19029439-1	2009	Hemojuvelin (HJV) was recently identified as a critical regulator of iron homeostasis.	Iron	69-73	hemojuvelin BMP co-receptor	Homo sapiens	13-16
19029439-3	2009	Membrane-anchored HJV acts as a coreceptor for bone morphogenetic proteins and activates the transcription of hepcidin, a hormone that regulates iron efflux from cells.	Iron	145-149	hemojuvelin BMP co-receptor	Homo sapiens	18-21
19029439-3	2009	Membrane-anchored HJV acts as a coreceptor for bone morphogenetic proteins and activates the transcription of hepcidin, a hormone that regulates iron efflux from cells.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	110-118
19228389-0	2009	Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1.	Iron	39-43	C-C motif chemokine ligand 2	Homo sapiens	47-81
19228389-6	2009	The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine.	Iron	26-30	C-C motif chemokine ligand 2	Homo sapiens	65-99
19228389-6	2009	The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine.	Iron	26-30	C-C motif chemokine ligand 2	Homo sapiens	101-106
19228389-6	2009	The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine.	Iron	159-163	C-C motif chemokine ligand 2	Homo sapiens	65-99
19228389-6	2009	The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine.	Iron	159-163	C-C motif chemokine ligand 2	Homo sapiens	101-106
19228389-10	2009	We further examined the relationship between iron and MCP-1 and found MCP-1 secretion tightly associated with intracellular iron status.	Iron	45-49	C-C motif chemokine ligand 2	Homo sapiens	54-59
19228389-10	2009	We further examined the relationship between iron and MCP-1 and found MCP-1 secretion tightly associated with intracellular iron status.	Iron	45-49	C-C motif chemokine ligand 2	Homo sapiens	70-75
19228389-10	2009	We further examined the relationship between iron and MCP-1 and found MCP-1 secretion tightly associated with intracellular iron status.	Iron	124-128	C-C motif chemokine ligand 2	Homo sapiens	70-75
19036700-1	2009	Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe).	Iron	99-103	heme oxygenase 1	Homo sapiens	27-43
19036700-1	2009	Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe).	Iron	99-103	heme oxygenase 1	Homo sapiens	45-49
19036700-1	2009	Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe).	Iron	105-107	heme oxygenase 1	Homo sapiens	27-43
19036700-1	2009	Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe).	Iron	105-107	heme oxygenase 1	Homo sapiens	45-49
19146390-1	2009	Human NFU (also known as HIRIP5) has been implicated in cellular iron-sulfur cluster biosynthesis.	Iron	65-69	NFU1 iron-sulfur cluster scaffold	Homo sapiens	25-31
19061943-9	2009	However, the mRNA expression for ceruloplasmin and divalent metal transporter 1 (DMT1) IRE(+) in the adenomas was altered independently of iron status, and the dysregulation may contribute to diminished iron content.	Iron	139-143	ceruloplasmin	Mus musculus	33-46
19061943-9	2009	However, the mRNA expression for ceruloplasmin and divalent metal transporter 1 (DMT1) IRE(+) in the adenomas was altered independently of iron status, and the dysregulation may contribute to diminished iron content.	Iron	203-207	ceruloplasmin	Mus musculus	33-46
19102690-1	2009	Combined experimental and computational studies suggest that the iron-mediated aziridination of cis-1-phenylpropene proceeds along two mechanistic pathways that share a common imidoiron(IV) intermediate.	Iron	65-69	suppressor of cytokine signaling 1	Homo sapiens	96-101
20107533-1	2009	Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR).	Iron	140-152	heme oxygenase 1	Homo sapiens	0-21
18810491-0	2009	Inhibition of HBV infection by bovine lactoferrin and iron-, zinc-saturated lactoferrin.	Iron	54-60	lactotransferrin	Bos taurus	76-87
18810491-3	2009	BLf, iron- or zinc-saturated lactoferrin significantly inhibited the amplification of HBV-DNA in a dose-dependent manner in HBV-infected HepG2 cells.	Iron	5-9	lactotransferrin	Bos taurus	29-40
19178651-5	2009	The relationship between inflammation and iron absorption may be mediated by hepcidin, although further studies will be required to confirm this potential physiological explanation for the increased prevalence of iron deficiency in the obese.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	77-85
19019832-1	2009	Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain.	Iron	82-86	ceruloplasmin	Homo sapiens	0-13
19019832-1	2009	Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain.	Iron	82-86	ceruloplasmin	Homo sapiens	15-17
19019832-1	2009	Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain.	Iron	160-164	ceruloplasmin	Homo sapiens	0-13
19019832-1	2009	Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain.	Iron	160-164	ceruloplasmin	Homo sapiens	15-17
19019832-1	2009	Ceruloplasmin (Cp), a copper-containing protein, plays a significant role in body iron homeostasis as aceruloplasminemia patients and Cp knock-out mice exhibit iron overload in several tissues including liver and brain.	Iron	160-164	ceruloplasmin	Homo sapiens	134-136
18951868-1	2009	Hepcidin is a peptide hormone that functions as a key regulator of mammalian iron metabolism.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	0-8
19123922-1	2009	Heme oxygenase-1 (HO-1) catalyzes the oxidative degradation of heme to biliverdin, carbon monoxide, and free iron in a reaction requiring the interaction of HO-1 with NADPH-cytochrome P450 reductase (CPR).	Iron	109-113	heme oxygenase 1	Homo sapiens	0-16
19123922-1	2009	Heme oxygenase-1 (HO-1) catalyzes the oxidative degradation of heme to biliverdin, carbon monoxide, and free iron in a reaction requiring the interaction of HO-1 with NADPH-cytochrome P450 reductase (CPR).	Iron	109-113	heme oxygenase 1	Homo sapiens	18-22
19123922-1	2009	Heme oxygenase-1 (HO-1) catalyzes the oxidative degradation of heme to biliverdin, carbon monoxide, and free iron in a reaction requiring the interaction of HO-1 with NADPH-cytochrome P450 reductase (CPR).	Iron	109-113	heme oxygenase 1	Homo sapiens	157-161
19001370-6	2009	Moreover, this study details the first functional analysis of mutant variants of the ever expanding family of ApbC/Nbp35 [Fe-S] cluster biosynthetic proteins.	Iron	122-126	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	115-120
19414144-1	2009	Haemochromatosis should currently refer to hereditary iron overload disorders presenting with a definite and common phenotype characterised by normal erythropoiesis, increased transferrin saturation and ferritin and primarily parenchymal iron deposition related to innate low (but normally regulated) production of the hepatic peptide hormone hepcidin.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	343-351
19019709-4	2009	Using the erythroleukemic K562 TfR2(+) cells as a model, we observed that agents that enhance c-Myc expression, such as iron, determine a decrease of TfR2 expression, while molecules that induce a decreased c-Myc expression, such as the iron chelator desferoxamine or the kinase inhibitor ST 1571, induce an enhanced TfR2 expression.	Iron	120-124	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
19019709-4	2009	Using the erythroleukemic K562 TfR2(+) cells as a model, we observed that agents that enhance c-Myc expression, such as iron, determine a decrease of TfR2 expression, while molecules that induce a decreased c-Myc expression, such as the iron chelator desferoxamine or the kinase inhibitor ST 1571, induce an enhanced TfR2 expression.	Iron	120-124	transferrin receptor 2	Homo sapiens	150-154
19019709-4	2009	Using the erythroleukemic K562 TfR2(+) cells as a model, we observed that agents that enhance c-Myc expression, such as iron, determine a decrease of TfR2 expression, while molecules that induce a decreased c-Myc expression, such as the iron chelator desferoxamine or the kinase inhibitor ST 1571, induce an enhanced TfR2 expression.	Iron	120-124	transferrin receptor 2	Homo sapiens	150-154
19019709-4	2009	Using the erythroleukemic K562 TfR2(+) cells as a model, we observed that agents that enhance c-Myc expression, such as iron, determine a decrease of TfR2 expression, while molecules that induce a decreased c-Myc expression, such as the iron chelator desferoxamine or the kinase inhibitor ST 1571, induce an enhanced TfR2 expression.	Iron	237-241	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
19019709-6	2009	The ensemble of these observations suggests that in cancer cell lines TfR2 expression can be modulated through stimuli similar to those known to act on TfR1 and these findings may have important implications for our understanding of the role of TfR2 in the regulation of iron homeostasis.	Iron	271-275	transferrin receptor 2	Homo sapiens	70-74
19019709-6	2009	The ensemble of these observations suggests that in cancer cell lines TfR2 expression can be modulated through stimuli similar to those known to act on TfR1 and these findings may have important implications for our understanding of the role of TfR2 in the regulation of iron homeostasis.	Iron	271-275	transferrin receptor 2	Homo sapiens	245-249
19839227-0	2009	Development of a novel immunoassay for the iron regulatory peptide hepcidin.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	67-75
19839227-1	2009	To date there have been few published immunoassays for the important iron regulator hepcidin.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	84-92
19839227-17	2009	A robust and optimised immunoassay for bioactive hepcidin has been produced and the patient sample results obtained further validates the important role of hepcidin in iron regulation, and will allow further investigation of this important peptide and its role in iron homeostasis.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	49-57
19839227-17	2009	A robust and optimised immunoassay for bioactive hepcidin has been produced and the patient sample results obtained further validates the important role of hepcidin in iron regulation, and will allow further investigation of this important peptide and its role in iron homeostasis.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	156-164
19839227-17	2009	A robust and optimised immunoassay for bioactive hepcidin has been produced and the patient sample results obtained further validates the important role of hepcidin in iron regulation, and will allow further investigation of this important peptide and its role in iron homeostasis.	Iron	264-268	hepcidin antimicrobial peptide	Homo sapiens	49-57
19028700-0	2009	Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma.	Iron	78-82	aminoacylase 1	Rattus norvegicus	60-74
19759876-2	2009	Other mutations have been described in the HFE gene as well as in genes involved in iron metabolism, such as transferrin receptor 2 (TfR2) and ferroportin 1 (SCL40A1).	Iron	84-88	transferrin receptor 2	Homo sapiens	109-131
19759876-2	2009	Other mutations have been described in the HFE gene as well as in genes involved in iron metabolism, such as transferrin receptor 2 (TfR2) and ferroportin 1 (SCL40A1).	Iron	84-88	transferrin receptor 2	Homo sapiens	133-137
19759876-2	2009	Other mutations have been described in the HFE gene as well as in genes involved in iron metabolism, such as transferrin receptor 2 (TfR2) and ferroportin 1 (SCL40A1).	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	143-156
18952085-8	2009	Overexpression of hemojuvelin in HuH7 hepatoma cells led to a significant increase in cellular iron content.	Iron	95-99	hemojuvelin BMP co-receptor	Homo sapiens	18-29
18815198-0	2009	Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia.	Iron	72-76	ferritin mitochondrial	Homo sapiens	0-22
18815198-1	2009	Mitochondrial ferritin (FtMt) is a nuclear-encoded iron-sequestering protein that specifically localizes in mitochondria.	Iron	51-55	ferritin mitochondrial	Homo sapiens	0-22
18815198-1	2009	Mitochondrial ferritin (FtMt) is a nuclear-encoded iron-sequestering protein that specifically localizes in mitochondria.	Iron	51-55	ferritin mitochondrial	Homo sapiens	24-28
18815198-3	2009	FtMt expression in mammalian cells was shown to cause a shift of iron from cytosol to mitochondria, and in yeast it rescued the defects associated with frataxin deficiency.	Iron	65-69	ferritin mitochondrial	Homo sapiens	0-4
18815198-6	2009	Furthermore, FtMt expression reduces the size of cytosolic and mitochondrial labile iron pools.	Iron	84-88	ferritin mitochondrial	Homo sapiens	13-17
18815198-7	2009	In cells grown in glucose-free media, FtMt level was reduced owing to faster degradation rate, however it still protected the activity of mitochondrial Fe-S enzymes without affecting the cytosolic iron status.	Iron	152-156	ferritin mitochondrial	Homo sapiens	38-42
18815198-9	2009	These results indicate that the primary function of FtMt involves the control of ROS formation through the regulation of mitochondrial iron availability.	Iron	135-139	ferritin mitochondrial	Homo sapiens	52-56
19549626-1	2009	Roots of some gramineous plants secrete phytosiderophores in response to iron deficiency and take up Fe as a ferric-phytosiderophore complex through the transporter YS1 (Yellow Stripe 1).	Iron	101-103	iron-phytosiderophore transporter yellow stripe 1	Zea mays	165-168
19549626-10	2009	These differences in gene expression pattern and tissue-type specificity of localization suggest that HvYS1 is only involved in primary Fe acquisition by barley roots, whereas ZmYS1 is involved in both primary Fe acquisition and intracellular transport of iron and other metals in maize.	Iron	210-212	iron-phytosiderophore transporter yellow stripe 1	Zea mays	176-181
19549626-10	2009	These differences in gene expression pattern and tissue-type specificity of localization suggest that HvYS1 is only involved in primary Fe acquisition by barley roots, whereas ZmYS1 is involved in both primary Fe acquisition and intracellular transport of iron and other metals in maize.	Iron	256-260	iron-phytosiderophore transporter yellow stripe 1	Zea mays	176-181
19747625-4	2009	Adult CP null (CP(-/-)) mice show increased iron deposition in several regions of brain, such as the cerebellum and brainstem.	Iron	44-48	ceruloplasmin	Mus musculus	6-8
19747625-4	2009	Adult CP null (CP(-/-)) mice show increased iron deposition in several regions of brain, such as the cerebellum and brainstem.	Iron	44-48	ceruloplasmin	Mus musculus	15-17
19747625-8	2009	In contrast, the substantia nigra and cerebellum of 80-week-old CP(-/-) mice accumulate iron but do not express high levels or significant decrease of Heph, suggesting that Heph does not replace CP in these regions.	Iron	88-92	ceruloplasmin	Mus musculus	64-66
19287179-1	2009	Hemojuvelin (HJV) is a membrane protein that is responsible for the iron overload condition known as juvenile hemochromatosis.	Iron	68-72	hemojuvelin BMP co-receptor	Homo sapiens	0-11
19287179-1	2009	Hemojuvelin (HJV) is a membrane protein that is responsible for the iron overload condition known as juvenile hemochromatosis.	Iron	68-72	hemojuvelin BMP co-receptor	Homo sapiens	13-16
19287179-2	2009	HJV, highly expressed in the liver, skeletal muscle and heart, seems to play a role in iron absorption and release from cells and has anti-inflammatory properties.	Iron	87-91	hemojuvelin BMP co-receptor	Homo sapiens	0-3
19287179-5	2009	Moreover, HJV plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway, although through unknown mechanisms.	Iron	100-104	hemojuvelin BMP co-receptor	Homo sapiens	10-13
19287179-5	2009	Moreover, HJV plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway, although through unknown mechanisms.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	59-67
19287179-6	2009	Dietary iron sensing and inflammatory pathways converge in the regulation of the key regulator hepcidin, but how these two pathways intersect remains unclear.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	95-103
19287179-7	2009	Inflammation, through downregulation of hepatic HJV, might induce temporary elimination of iron sensing.	Iron	91-95	hemojuvelin BMP co-receptor	Homo sapiens	48-51
19287179-8	2009	Despite enormous scientific achievements in explaining the pathogenetic mechanisms of iron metabolism, many questions still remain unanswered: What is the functional role of HJV in iron metabolism?	Iron	181-185	hemojuvelin BMP co-receptor	Homo sapiens	174-177
19287179-10	2009	How do iron-sensing and inflammatory pathways cooperate in hepcidin gene expression?	Iron	7-11	hepcidin antimicrobial peptide	Homo sapiens	59-67
17588710-7	2009	In APP/PS1 mice, spots detection was related to high iron and calcium load within amyloid plaques and thus reflects the ability of such plaque to capture large amounts of minerals.	Iron	53-57	presenilin 1	Mus musculus	7-10
19839848-1	2009	Hepcidin is the key regulator of iron metabolism.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
18584923-1	2009	Hepcidin inhibits intestinal absorption of iron through internalisation of ferroportin.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
19005224-2	2009	Studies have suggested that the oxidase protein ceruloplasmin (Cp) mediates iron and manganese oxidation and loading onto plasma transferrin (Tf), as well as cellular iron efflux.	Iron	76-80	ceruloplasmin	Mus musculus	48-61
19005224-2	2009	Studies have suggested that the oxidase protein ceruloplasmin (Cp) mediates iron and manganese oxidation and loading onto plasma transferrin (Tf), as well as cellular iron efflux.	Iron	167-171	ceruloplasmin	Mus musculus	48-61
19021540-1	2008	Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation.	Iron	126-130	ceruloplasmin	Homo sapiens	52-65
19021540-1	2008	Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation.	Iron	126-130	ceruloplasmin	Homo sapiens	67-69
19021540-4	2008	We now know that (i) Cp regulates the efficiency of iron efflux, (ii) Cp stabilizes ferroportin membrane expression, (iii) GPI (glycosylphosphatidylinositol)-linked Cp is the predominant form expressed in brain, (iv) Cp functions as a ferroxidase and regulates the oxidation of Fe(2+) to Fe(3+), (v) Cp does not bind to transferrin directly, and (vi) Cp is one member of a family of mammalian MCOs, which includes hephaestin.	Iron	52-56	ceruloplasmin	Homo sapiens	21-23
19021540-4	2008	We now know that (i) Cp regulates the efficiency of iron efflux, (ii) Cp stabilizes ferroportin membrane expression, (iii) GPI (glycosylphosphatidylinositol)-linked Cp is the predominant form expressed in brain, (iv) Cp functions as a ferroxidase and regulates the oxidation of Fe(2+) to Fe(3+), (v) Cp does not bind to transferrin directly, and (vi) Cp is one member of a family of mammalian MCOs, which includes hephaestin.	Iron	278-280	ceruloplasmin	Homo sapiens	21-23
19021540-4	2008	We now know that (i) Cp regulates the efficiency of iron efflux, (ii) Cp stabilizes ferroportin membrane expression, (iii) GPI (glycosylphosphatidylinositol)-linked Cp is the predominant form expressed in brain, (iv) Cp functions as a ferroxidase and regulates the oxidation of Fe(2+) to Fe(3+), (v) Cp does not bind to transferrin directly, and (vi) Cp is one member of a family of mammalian MCOs, which includes hephaestin.	Iron	288-290	ceruloplasmin	Homo sapiens	21-23
18809758-3	2008	Two genes known to modify iron loading in hh are hepcidin (HAMP) and hemojuvelin (HJV).	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	49-57
18809758-3	2008	Two genes known to modify iron loading in hh are hepcidin (HAMP) and hemojuvelin (HJV).	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	59-63
18809758-3	2008	Two genes known to modify iron loading in hh are hepcidin (HAMP) and hemojuvelin (HJV).	Iron	26-30	hemojuvelin BMP co-receptor	Homo sapiens	69-80
18809758-3	2008	Two genes known to modify iron loading in hh are hepcidin (HAMP) and hemojuvelin (HJV).	Iron	26-30	hemojuvelin BMP co-receptor	Homo sapiens	82-85
18809758-9	2008	Hepatic HAMP expression in patients with PCT was significantly reduced, regardless of HFE genotype, when compared with patients with hh but without PCT with comparable iron overload.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	8-12
18976966-1	2008	The liver peptide hepcidin regulates body iron, is upregulated in iron overload and inflammation, and is downregulated in iron deficiency/hypoxia.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	18-26
18976966-1	2008	The liver peptide hepcidin regulates body iron, is upregulated in iron overload and inflammation, and is downregulated in iron deficiency/hypoxia.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	18-26
18799798-1	2008	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron, and bilirubin.	Iron	147-151	heme oxygenase 1	Homo sapiens	0-16
18799798-1	2008	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron, and bilirubin.	Iron	147-151	heme oxygenase 1	Homo sapiens	18-22
18844346-2	2008	The reconstituted ferric myoglobin was found to be five-coordinate without iron-bound water molecules.	Iron	75-79	myoglobin	Homo sapiens	25-34
18844346-8	2008	The ligand binding analyses for the ferric and ferrous myoglobin suggest that the proximal histidine pulls the iron atom from the deformed core to reduce the interaction between the iron and exogenous ligands.	Iron	111-115	myoglobin	Homo sapiens	55-64
18844346-8	2008	The ligand binding analyses for the ferric and ferrous myoglobin suggest that the proximal histidine pulls the iron atom from the deformed core to reduce the interaction between the iron and exogenous ligands.	Iron	182-186	myoglobin	Homo sapiens	55-64
19002083-14	2008	A number of proteins is involved in iron metabolism including: ferritin, transferrin,transferrin receptor, divalent metal transporter (DMT1), cytochrome b, ferroportin, hephaestin, hepcidin and lactoferrin (LF).	Iron	36-40	solute carrier family 11 member 2	Homo sapiens	135-139
18694648-6	2008	Interestingly, serum hepcidin levels are associated with serum ferritin levels (r=0.64, p&lt;0.0001) but not with sTfR1 levels (r=0.06, p=0.70), indicating that hepcidin is a measure of iron overload.	Iron	186-190	hepcidin antimicrobial peptide	Homo sapiens	21-29
18694996-0	2008	Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.	Iron	25-29	signal transducer and activator of transcription 5A	Mus musculus	0-5
18694996-7	2008	This establishes an unexpected mechanistic link between EpoR/Jak/Stat signaling and iron metabolism, processes absolutely essential for erythropoiesis and life.	Iron	84-88	erythropoietin receptor	Mus musculus	56-60
18459044-3	2008	Antiserum to TfBP selectively stains transferrin- and iron-rich oligodendrocytes and choroidal epithelium in the adult and embryonic chick brain, suggesting a role for this protein in transferrin and iron storage in these cells.	Iron	54-58	heat shock protein 90 beta family member 1	Gallus gallus	13-17
18459044-3	2008	Antiserum to TfBP selectively stains transferrin- and iron-rich oligodendrocytes and choroidal epithelium in the adult and embryonic chick brain, suggesting a role for this protein in transferrin and iron storage in these cells.	Iron	200-204	heat shock protein 90 beta family member 1	Gallus gallus	13-17
18459044-8	2008	The up-regulated expression of TfBP, together with the Tf-receptor of the brain capillaries, suggests that pericytes may be associated with the high iron uptake required for the metabolic demands of the developing brain.	Iron	149-153	heat shock protein 90 beta family member 1	Gallus gallus	31-35
18723004-4	2008	Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15.	Iron	126-130	cystatin C	Rattus norvegicus	104-108
18723004-4	2008	Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15.	Iron	126-130	fibronectin 1	Rattus norvegicus	110-113
18723004-4	2008	Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15.	Iron	126-130	lysine acetyltransferase 5	Rattus norvegicus	115-121
18676996-0	2008	An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.	Iron	3-7	alpha hemoglobin stabilizing protein	Homo sapiens	52-88
18676996-2	2008	We discovered that iron regulates the expression of alpha-hemoglobin-stabilizing protein (AHSP), a molecular chaperone that binds and stabilizes free alpha-globin during hemoglobin synthesis.	Iron	19-23	alpha hemoglobin stabilizing protein	Homo sapiens	52-88
18676996-2	2008	We discovered that iron regulates the expression of alpha-hemoglobin-stabilizing protein (AHSP), a molecular chaperone that binds and stabilizes free alpha-globin during hemoglobin synthesis.	Iron	19-23	alpha hemoglobin stabilizing protein	Homo sapiens	90-94
18676996-3	2008	In primates, the 3"-untranslated region (UTR) of AHSP mRNA contains a nucleotide sequence resembling iron responsive elements (IREs), stem-loop structures that regulate gene expression post-transcriptionally by binding iron regulatory proteins (IRPs).	Iron	101-105	alpha hemoglobin stabilizing protein	Homo sapiens	49-53
18676996-3	2008	In primates, the 3"-untranslated region (UTR) of AHSP mRNA contains a nucleotide sequence resembling iron responsive elements (IREs), stem-loop structures that regulate gene expression post-transcriptionally by binding iron regulatory proteins (IRPs).	Iron	219-223	alpha hemoglobin stabilizing protein	Homo sapiens	49-53
18676996-5	2008	However, in cytoplasmic extracts, AHSP mRNA co-immunoprecipitates with IRPs in a fashion that is dependent on the stem-loop structure and inhibited by iron.	Iron	151-155	alpha hemoglobin stabilizing protein	Homo sapiens	34-38
18925311-2	2008	BACKGROUND: Hepcidin is a circulating hepatic hormone that regulates iron balance.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	12-20
18672098-7	2008	DNA-PK and ATM are required, to different extents, for the partial repair of Fe-induced DNA damage.	Iron	77-79	ATM serine/threonine kinase	Homo sapiens	11-14
18725184-11	2008	In the patients with the homozygous HJV mutation, iron loading revealed high serum ferritin concentration with accompanying elevated transferrin iron saturation.	Iron	50-54	hemojuvelin BMP co-receptor	Homo sapiens	36-39
18725184-11	2008	In the patients with the homozygous HJV mutation, iron loading revealed high serum ferritin concentration with accompanying elevated transferrin iron saturation.	Iron	145-149	hemojuvelin BMP co-receptor	Homo sapiens	36-39
18815723-13	2008	Western Blot analyses revealed a long term down-regulating effect of ascorbic acid on iron independent and iron dependent Nramp2 and Dcytb expression.	Iron	107-111	solute carrier family 11 member 2	Homo sapiens	122-128
18815723-16	2008	However, the impact of iron alone on Nramp2 up-regulation seems to be greater in the absence of ascorbic acid.	Iron	23-27	solute carrier family 11 member 2	Homo sapiens	37-43
18815723-20	2008	Similarly, the short term up-regulation of Nramp2 and Dcytb seems to agree with the improvement in iron uptake shown in humans when single doses of ascorbic acid were administrated.	Iron	99-103	solute carrier family 11 member 2	Homo sapiens	43-49
18603562-0	2008	A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron.	Iron	122-126	hepcidin antimicrobial peptide	Homo sapiens	89-97
18603562-1	2008	BACKGROUND: Hepcidin plays a key role in body iron metabolism by preventing the release of iron from macrophages and intestinal cells.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	12-20
18603562-1	2008	BACKGROUND: Hepcidin plays a key role in body iron metabolism by preventing the release of iron from macrophages and intestinal cells.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	12-20
18603562-2	2008	Defective hepcidin synthesis causes iron loading, while overproduction results in defective reticuloendothelial iron release and iron absorption.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	10-18
18982432-3	2008	The NADH oxidation domain harbouring the FMN cofactor is connected via a chain of iron-sulfur clusters to the ubiquinone reduction site that is located in a large pocket formed by the PSST- and 49-kDa subunits of complex I.	Iron	82-86	formin 1	Homo sapiens	41-44
18679377-5	2008	Microarray studies detected an upregulation of mRNA for ceruloplasmin, a copper-containing iron transport protein with antioxidant ferroxidase properties, in PE compared to PC and TC placentas, respectively.	Iron	91-95	ceruloplasmin	Homo sapiens	56-69
18657084-6	2008	The striking biochemical characteristic of superdonors is greatly decreased serum hepcidin, consistent with their need to absorb maximal amounts of dietary iron to replace that lost from blood donation.	Iron	156-160	hepcidin antimicrobial peptide	Homo sapiens	82-90
18717590-1	2008	Yah1p, an [Fe 2S 2]-containing ferredoxin located in the matrix of Saccharomyces cerevisiae mitochondria, functions in the synthesis of Fe/S clusters and heme a prosthetic groups.	Iron	11-13	adrenodoxin	Saccharomyces cerevisiae S288C	0-5
18786476-1	2008	Hemoxygenase (HO)-1 is an inducible isoform of the first and rate-controlling enzyme of the degradation of heme into iron, carbon monoxide, and biliverdin, the latter being subsequently converted into bilirubin.	Iron	117-121	heme oxygenase 1	Homo sapiens	0-19
18596229-2	2008	Here, we show that iron deficiency anemia with poor intestinal absorption and defective iron utilization of IV iron is caused by inherited mutations in TMPRSS6, a liver-expressed gene that encodes a membrane-bound serine protease of previously unknown role that was recently reported to be a regulator of hepcidin expression.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	305-313
18596229-2	2008	Here, we show that iron deficiency anemia with poor intestinal absorption and defective iron utilization of IV iron is caused by inherited mutations in TMPRSS6, a liver-expressed gene that encodes a membrane-bound serine protease of previously unknown role that was recently reported to be a regulator of hepcidin expression.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	305-313
18571502-2	2008	Hepcidin, a key regulator of iron metabolism, may play an important role in the interdependence of inflammation and anemia in ESRD patients.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
18585019-8	2008	Iron injection increased LPO only in the small intestine and that effect was completely prevented by either GH or IGF-I.	Iron	0-4	insulin-like growth factor 1	Rattus norvegicus	114-119
18585019-10	2008	GH and IGF-I possess some ability to prevent iron-induced oxidative damage in iron sensitive tissues, but contribute to oxidative imbalance in other tissues.	Iron	45-49	insulin-like growth factor 1	Rattus norvegicus	7-12
18585019-10	2008	GH and IGF-I possess some ability to prevent iron-induced oxidative damage in iron sensitive tissues, but contribute to oxidative imbalance in other tissues.	Iron	78-82	insulin-like growth factor 1	Rattus norvegicus	7-12
18586980-2	2008	Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages.	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	0-13
18586980-2	2008	Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages.	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	15-19
18586980-2	2008	Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages.	Iron	42-46	solute carrier family 40 member 1	Homo sapiens	21-28
18758412-2	2008	Hepcidin, an antimicrobial peptide, is a key regulator of iron metabolism and synthesis of hepcidin is regulated by iron status and inflammation.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
18758412-2	2008	Hepcidin, an antimicrobial peptide, is a key regulator of iron metabolism and synthesis of hepcidin is regulated by iron status and inflammation.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	0-8
18758412-2	2008	Hepcidin, an antimicrobial peptide, is a key regulator of iron metabolism and synthesis of hepcidin is regulated by iron status and inflammation.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	91-99
18758412-9	2008	CONCLUSIONS: In EPO resistant anemia, multiple factors, including iron and inflammation related conditions, are likely to affect the level of hepcidin and this may explain the lack of elevated serum hepcidin in this condition.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	142-150
18573874-0	2008	Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.	Iron	44-48	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	6-11
18573874-0	2008	Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.	Iron	77-81	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	6-11
18665584-4	2008	In particular, three interactions of 4-PI analogues with IDO were studied: the active site entrance, the interior of the active site, and the heme iron binding.	Iron	147-151	indoleamine 2,3-dioxygenase 1	Homo sapiens	57-60
18539898-0	2008	Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.	Iron	0-4	SMAD family member 1	Mus musculus	34-43
18539898-0	2008	Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.	Iron	0-4	bone morphogenetic protein 6	Mus musculus	67-71
18539898-3	2008	Among 1419 transcripts significantly modulated by the dietary iron content, 4 were regulated similarly to the hepcidin genes Hamp1 and Hamp2.	Iron	62-66	hepcidin antimicrobial peptide 2	Mus musculus	135-140
18539898-5	2008	As shown by Western blot analysis, variations in Bmp6 expression induced by the diet iron content have for functional consequence similar changes in Smad1/5/8 phosphorylation that leads to formation of heteromeric complexes with Smad4 and their translocation to the nucleus.	Iron	85-89	bone morphogenetic protein 6	Mus musculus	49-53
18539898-5	2008	As shown by Western blot analysis, variations in Bmp6 expression induced by the diet iron content have for functional consequence similar changes in Smad1/5/8 phosphorylation that leads to formation of heteromeric complexes with Smad4 and their translocation to the nucleus.	Iron	85-89	SMAD family member 1	Mus musculus	149-156
18539898-5	2008	As shown by Western blot analysis, variations in Bmp6 expression induced by the diet iron content have for functional consequence similar changes in Smad1/5/8 phosphorylation that leads to formation of heteromeric complexes with Smad4 and their translocation to the nucleus.	Iron	85-89	SMAD family member 4	Mus musculus	229-234
18539898-7	2008	Iron overload developed by Smad4- and Hamp1-deficient mice also increased Bmp6 transcription.	Iron	0-4	SMAD family member 4	Mus musculus	27-32
18539898-7	2008	Iron overload developed by Smad4- and Hamp1-deficient mice also increased Bmp6 transcription.	Iron	0-4	bone morphogenetic protein 6	Mus musculus	74-78
18539898-8	2008	However, as shown by analysis of mice with liver-specific disruption of Smad4, activation of Smad7, Id1, and Atoh8 transcription by iron requires Smad4.	Iron	132-136	SMAD family member 4	Mus musculus	72-77
18539898-8	2008	However, as shown by analysis of mice with liver-specific disruption of Smad4, activation of Smad7, Id1, and Atoh8 transcription by iron requires Smad4.	Iron	132-136	SMAD family member 4	Mus musculus	146-151
18443197-3	2008	The aim of this study was to assess the association of the length of (GT)(n) repeats in the HO-1 gene promoter with serum bilirubin, markers of iron status, and the development of coronary artery disease (CAD).	Iron	144-148	heme oxygenase 1	Homo sapiens	92-96
18321736-1	2008	Iron homeostasis is mainly controlled by the liver-produced hepcidin peptide, which induces the degradation of the ferroportin iron exporter and thus regulates serum iron level.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	60-68
18321736-1	2008	Iron homeostasis is mainly controlled by the liver-produced hepcidin peptide, which induces the degradation of the ferroportin iron exporter and thus regulates serum iron level.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	60-68
18321736-1	2008	Iron homeostasis is mainly controlled by the liver-produced hepcidin peptide, which induces the degradation of the ferroportin iron exporter and thus regulates serum iron level.	Iron	166-170	hepcidin antimicrobial peptide	Homo sapiens	60-68
18321736-2	2008	Hepcidin transcription is clearly up-regulated by the pro-inflammatory cytokine IL-6 and down-regulated, in the case of iron depletion, at least via HIF transcription factors.	Iron	120-124	hepcidin antimicrobial peptide	Homo sapiens	0-8
18321736-3	2008	In addition, in vivo iron overload up-regulates hepcidin, but this cannot be reproduced in cell culture or isolated hepatocytes.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	48-56
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	64-72
18321736-5	2008	Our results showed that iron-saturated transferrin up-regulated hepcidin mRNA synthesis from HepG2 via cross-talk with macrophages or enterocyte cytokine-producing cells, whereas non-transferrin-bound iron down-regulated hepcidin, likely due to missing TfR-iron-transferrin uptake.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	221-229
18365240-7	2008	Hepcidin up-regulation has a negative impact on the iron transport and absorption channels within the body, and may explain a potential new mechanism behind iron deficiency in athletes.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
18546145-4	2008	As macrophages are central cells for controlling infections with intracellular bacteria such as Salmonella and Mycobacteria, modulation of iron by hepcidin can lead to the provision of an ideal cellular iron source for these pathogens.	Iron	139-143	hepcidin antimicrobial peptide	Homo sapiens	147-155
18546145-4	2008	As macrophages are central cells for controlling infections with intracellular bacteria such as Salmonella and Mycobacteria, modulation of iron by hepcidin can lead to the provision of an ideal cellular iron source for these pathogens.	Iron	203-207	hepcidin antimicrobial peptide	Homo sapiens	147-155
18427564-3	2008	Higher hepcidin levels in obesity may reduce dietary iron absorption.	Iron	53-57	hepcidin antimicrobial peptide	Homo sapiens	7-15
18462824-9	2008	The relatively elevated urinary hepcidin can explain the iron phenotype in DHIO (more macrophage iron retention and low/normal transferrin saturation).	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	32-40
18552864-4	2008	Other viruses alter the expression of proteins involved in iron homeostasis, such as HFE and hepcidin.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	93-101
18326822-1	2008	Hepcidin is the principal iron regulatory hormone, controlling the systemic absorption and remobilization of iron from intracellular stores.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	0-8
18326822-1	2008	Hepcidin is the principal iron regulatory hormone, controlling the systemic absorption and remobilization of iron from intracellular stores.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	0-8
18522836-2	2008	We have previously demonstrated in yeast that Cth2 is expressed during Fe deficiency and promotes degradation of a battery of mRNAs leading to reprogramming of Fe-dependent metabolism and Fe storage.	Iron	71-73	Tis11p	Saccharomyces cerevisiae S288C	46-50
18522836-2	2008	We have previously demonstrated in yeast that Cth2 is expressed during Fe deficiency and promotes degradation of a battery of mRNAs leading to reprogramming of Fe-dependent metabolism and Fe storage.	Iron	160-162	Tis11p	Saccharomyces cerevisiae S288C	46-50
18522836-3	2008	We report here that the Cth2-homologous protein Cth1 is transiently expressed during Fe deprivation and participates in the response to Fe deficiency through the degradation of mRNAs primarily involved in mitochondrially localized activities including respiration and amino acid biosynthesis.	Iron	85-87	Tis11p	Saccharomyces cerevisiae S288C	24-28
18522836-3	2008	We report here that the Cth2-homologous protein Cth1 is transiently expressed during Fe deprivation and participates in the response to Fe deficiency through the degradation of mRNAs primarily involved in mitochondrially localized activities including respiration and amino acid biosynthesis.	Iron	85-87	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	48-52
18492824-2	2008	It is thought to act as a ferric reductase that furnishes Fe(II), the specific and selective iron species transported by divalent metal transporter 1 (DMT1) in the duodenal enterocytes.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	121-149
18492824-2	2008	It is thought to act as a ferric reductase that furnishes Fe(II), the specific and selective iron species transported by divalent metal transporter 1 (DMT1) in the duodenal enterocytes.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	151-155
18492824-9	2008	Cotransfection of Dcytb and DMT1 resulted in an additive increase in iron uptake by the cells.	Iron	69-73	solute carrier family 11 member 2	Homo sapiens	28-32
18310660-1	2008	Hepcidin is a small bioactive peptide with dual roles as an antimicrobial peptide and as the principal hormonal regulator of iron homeostasis in human and mouse.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	0-8
18510925-2	2008	XPD has a 5" to 3" polarity and the helicase activity is dependent on an iron-sulfur cluster binding domain, a feature that is conserved in related helicases such as FancJ.	Iron	73-77	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-3
18510925-2	2008	XPD has a 5" to 3" polarity and the helicase activity is dependent on an iron-sulfur cluster binding domain, a feature that is conserved in related helicases such as FancJ.	Iron	73-77	BRCA1 interacting helicase 1	Homo sapiens	166-171
18453607-1	2008	Lactoferrin is an 80-kDa iron-binding protein present at high concentrations in milk and in the granules of neutrophils.	Iron	25-29	lactotransferrin	Mus musculus	0-11
18452427-0	2008	Prokaryotic expression and monoclonal antibody preparation of Mycobacterium tuberculosis ferric uptake regulator B. Ferric uptake regulator B (FurB) of Mycobacterium tuberculosis, which belongs to the Fur superfamily, is principally responsible for maintaining iron and zinc homeostasis in prokaryotes.	Iron	261-265	zinc uptake regulation protein	Mycobacterium tuberculosis H37Rv	143-147
18452427-1	2008	This common feature of FurB and the role of FurB in iron and zinc metabolism contribute to research on the pathogenesis of mycobacteria.	Iron	52-56	zinc uptake regulation protein	Mycobacterium tuberculosis H37Rv	44-48
18295606-0	2008	Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	65-73
18295606-2	2008	It functions as a hormonal regulator of iron homeostasis by controlling iron efflux from target cells via ferroportin (FPN1), which is internalized and degraded upon hepcidin binding.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	166-174
18164223-1	2008	INTRODUCTION: Insufficient production of hepcidin, the master regulator of iron metabolism, is recognized as the key pathogenetic feature of HFE-related hereditary hemochromatosis (HH).	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	41-49
18164223-14	2008	Our results in phlebotomized patients suggest that the depletion of iron stores may further exacerbate the HFE-related hepcidin defect.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	119-127
18082289-4	2008	The aim of the present study is to construct recombinant adenovirus encoding human DMT1 with iron responsive element (DMT1+IRE) and infect MES23.5 dopaminergic cells in order to investigate the relationship between increased DMT1+IRE expression and iron accumulation.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	83-87
18082289-4	2008	The aim of the present study is to construct recombinant adenovirus encoding human DMT1 with iron responsive element (DMT1+IRE) and infect MES23.5 dopaminergic cells in order to investigate the relationship between increased DMT1+IRE expression and iron accumulation.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	118-122
18082289-4	2008	The aim of the present study is to construct recombinant adenovirus encoding human DMT1 with iron responsive element (DMT1+IRE) and infect MES23.5 dopaminergic cells in order to investigate the relationship between increased DMT1+IRE expression and iron accumulation.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	118-122
18082289-4	2008	The aim of the present study is to construct recombinant adenovirus encoding human DMT1 with iron responsive element (DMT1+IRE) and infect MES23.5 dopaminergic cells in order to investigate the relationship between increased DMT1+IRE expression and iron accumulation.	Iron	249-253	solute carrier family 11 member 2	Homo sapiens	83-87
18082289-13	2008	These results suggested that increased DMT1+IRE expression in MES23.5 cells caused the increased intracellular iron accumulation.	Iron	111-115	solute carrier family 11 member 2	Homo sapiens	39-43
18408718-2	2008	Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	268-276
18408718-2	2008	Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	268-276
18355020-2	2008	The dissociation constant for the apo form was (Kd)=2.2 x 10(-7) M; however, the specific binding of the iron-saturated rhLF and of lactoferrin from human milk (hLF) was too low to calculate the binding parameters.	Iron	105-109	HLF transcription factor, PAR bZIP family member	Homo sapiens	121-124
18355020-5	2008	Nevertheless, the amount of iron-saturated hLF transported across Caco-2 monolayers was significantly higher than that of rhLF.	Iron	28-32	HLF transcription factor, PAR bZIP family member	Homo sapiens	43-46
18258594-0	2008	Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.	Iron	36-40	synuclein alpha	Homo sapiens	62-77
18022819-4	2008	Ceruloplasmin (Cp) is the major multicopper ferroxidase in blood; however, hephaestin (Hp), a membrane-bound Cp homolog, was recently discovered and has been implicated in the export of iron from duodenal enterocytes into blood.	Iron	186-190	ceruloplasmin	Homo sapiens	0-13
18258795-0	2008	Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators.	Iron	67-71	arachidonate 15-lipoxygenase	Rattus norvegicus	43-49
18258795-5	2008	TaqMan real-time PCR studies demonstrated strong induction of Alox15 throughout the small and large intestine, and in the liver of iron-deficient rats.	Iron	131-135	arachidonate 15-lipoxygenase	Rattus norvegicus	62-68
18371544-3	2008	HO-1, an integral component of an important cytoprotective mechanism, mediates its action through removal of heme, the generation of heme breakdown reaction products (biliverdin, free iron, and carbon monoxide), and modulation of key cellular molecules.	Iron	184-188	heme oxygenase 1	Homo sapiens	0-4
18222182-0	2008	Transcripts of ceruloplasmin but not hepcidin, both major iron metabolism genes, exhibit a decreasing pattern along the portocentral axis of mouse liver.	Iron	58-62	ceruloplasmin	Mus musculus	15-28
18222182-6	2008	RESULTS: Transcripts of ceruloplasmin, involved in iron efflux, were overexpressed in periportal areas and the result was confirmed by in situ hybridization study.	Iron	51-55	ceruloplasmin	Mus musculus	24-37
18222182-9	2008	The preferential periportal expression of ceruloplasmin raises the issue of its special role in iron overload disorders involving a defect in cellular iron export.	Iron	96-100	ceruloplasmin	Mus musculus	42-55
17996030-0	2008	CSF proteomic analysis reveals persistent iron deficiency-induced alterations in non-human primate infants.	Iron	42-46	colony stimulating factor 2	Homo sapiens	0-3
17996030-7	2008	The CSF proteome for both formerly iron deficient groups was similar and revealed 12 proteins with expression levels altered at least twofold.	Iron	35-39	colony stimulating factor 2	Homo sapiens	4-7
18322945-1	2008	AIM: To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	54-62
18078827-6	2008	CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide and, in the presence of iron catalysts, produces powerful oxidants such as the hydroxyl radical.	Iron	148-152	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
18216035-10	2008	CONCLUSIONS: The haemoglobin-HO-1 system may be required to ensure adequate regulation of the bioavailability of haeme, iron and oxygen in human endometrium.	Iron	120-124	heme oxygenase 1	Homo sapiens	29-33
18281333-1	2008	Divalent metal ion transporter 1 (DMT1; also known as SLC11A2) can transport several metals including Fe and Cu in mammalian systems.	Iron	102-104	solute carrier family 11 member 2	Homo sapiens	0-32
18281333-1	2008	Divalent metal ion transporter 1 (DMT1; also known as SLC11A2) can transport several metals including Fe and Cu in mammalian systems.	Iron	102-104	solute carrier family 11 member 2	Homo sapiens	34-38
18281333-1	2008	Divalent metal ion transporter 1 (DMT1; also known as SLC11A2) can transport several metals including Fe and Cu in mammalian systems.	Iron	102-104	solute carrier family 11 member 2	Homo sapiens	54-61
21490838-1	2008	Recent research evidence suggests a central role for hepcidin in iron homeostasis.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	53-61
18160403-4	2008	FTL and FTH are regulated primarily at a post-transcriptional level in response to cellular iron concentrations.	Iron	92-96	ferritin heavy chain 1	Homo sapiens	8-11
18187051-10	2008	Brain cells from aceruloplasminemia with mutations in the ceruloplasmin gene take up iron by Tf-IU.	Iron	85-89	ceruloplasmin	Homo sapiens	18-31
18177470-0	2008	Novel mutations of the ferroportin gene (SLC40A1): analysis of 56 consecutive patients with unexplained iron overload.	Iron	104-108	solute carrier family 40 member 1	Homo sapiens	41-48
18177470-1	2008	The aim of this study was to search for SLC40A1 mutations in iron overloaded patients, which tested negative for HFE mutations and other iron-related genes.	Iron	61-65	solute carrier family 40 member 1	Homo sapiens	40-47
17991445-0	2008	Ceruloplasmin expression by human peripheral blood lymphocytes: a new link between immunity and iron metabolism.	Iron	96-100	ceruloplasmin	Homo sapiens	0-13
17991445-8	2008	In this context, the involvement of lymphocyte-derived CP on host defense processes via its anti/prooxidant properties is proposed, giving further support for a close functional interaction between the immune system and the Fe metabolism.	Iron	224-226	ceruloplasmin	Homo sapiens	55-57
17998435-10	2008	The low RFI line also had 33 g/d lower ADG (P = 0.022), 1.36% greater FE (P = 0.09), and 1.99 mm less BF (P = 0.013).	Iron	70-72	RFI	Sus scrofa	8-11
17947394-7	2008	The profound suppression of HCP-1 expression by inflammatory macrophage activation parallels the regulation of the iron exporter ferroportin.	Iron	115-119	solute carrier family 46 member 1	Homo sapiens	28-33
17947394-9	2008	Given the spatial relationship, we propose that the Hb scavenger receptor CD163 and HCP-1 constitute a linked pathway for Hb catabolism and heme-iron recycling in human macrophages.	Iron	145-149	solute carrier family 46 member 1	Homo sapiens	84-89
18223381-1	2008	OBJECTIVES: A primary objective was to evaluate whether addition of enteral iron supplementation will facilitate a systemic erythropoietic effect when feeding erythropoietin (Epo) to suckling rats.	Iron	76-80	erythropoietin	Rattus norvegicus	159-173
18223381-1	2008	OBJECTIVES: A primary objective was to evaluate whether addition of enteral iron supplementation will facilitate a systemic erythropoietic effect when feeding erythropoietin (Epo) to suckling rats.	Iron	76-80	erythropoietin	Rattus norvegicus	175-178
18223381-10	2008	Duodenal villous height was taller in Epo 1700+Fe compared with control + Fe, P &lt; 0.01.	Iron	47-49	erythropoietin	Rattus norvegicus	38-41
18223381-11	2008	CONCLUSIONS: If combined with sufficient iron supplementation, high-dose Epo artificially fed to suckling rats exerted a systemic erythropoietic effect in addition to the previously reported local trophic effects.	Iron	41-45	erythropoietin	Rattus norvegicus	73-76
18070921-0	2008	Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.	Iron	11-15	Yap5p	Saccharomyces cerevisiae S288C	0-4
18070921-0	2008	Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.	Iron	77-81	Yap5p	Saccharomyces cerevisiae S288C	0-4
18070921-2	2008	CCC1 mRNA is destabilized under low-iron conditions by the binding of Cth1 and Cth2 to the 3" untranslated region (S. Puig, E. Askeland, and D. J. Thiele, Cell 120:99-110, 2005).	Iron	36-40	putative mRNA-binding protein CTH1	Saccharomyces cerevisiae S288C	70-74
18070921-2	2008	CCC1 mRNA is destabilized under low-iron conditions by the binding of Cth1 and Cth2 to the 3" untranslated region (S. Puig, E. Askeland, and D. J. Thiele, Cell 120:99-110, 2005).	Iron	36-40	Tis11p	Saccharomyces cerevisiae S288C	79-83
18070921-4	2008	We identified YAP5 as being the iron-sensitive transcription factor and show that a yap5Delta strain is sensitive to high iron.	Iron	32-36	Yap5p	Saccharomyces cerevisiae S288C	14-18
18070921-4	2008	We identified YAP5 as being the iron-sensitive transcription factor and show that a yap5Delta strain is sensitive to high iron.	Iron	122-126	Yap5p	Saccharomyces cerevisiae S288C	14-18
18070921-5	2008	Green fluorescent protein-tagged Yap5 is localized to the nucleus and occupies the CCC1 promoter independent of the iron concentration.	Iron	116-120	Yap5p	Saccharomyces cerevisiae S288C	33-37
18070921-7	2008	The fusion of the Yap5 cysteine-containing domains to a GAL4 DNA binding domain results in iron-sensitive GAL1-lacZ expression.	Iron	91-95	Yap5p	Saccharomyces cerevisiae S288C	18-22
18070921-8	2008	Iron affects the sulfhydryl status of Yap5, which is indicative of the generation of intramolecular disulfide bonds.	Iron	0-4	Yap5p	Saccharomyces cerevisiae S288C	38-42
18070921-9	2008	These results show that Yap5 is an iron-sensing transcription factor and that iron regulates transcriptional activation.	Iron	35-39	Yap5p	Saccharomyces cerevisiae S288C	24-28
18070921-9	2008	These results show that Yap5 is an iron-sensing transcription factor and that iron regulates transcriptional activation.	Iron	78-82	Yap5p	Saccharomyces cerevisiae S288C	24-28
18046454-4	2008	We found that Fes interacts directly, through its SH2 domain, with ezrin phosphorylated at tyrosine 477.	Iron	14-17	ezrin	Homo sapiens	67-72
18046454-8	2008	Altogether, these results provide a novel mechanism whereby ezrin/Fes interaction at cell-cell contacts plays an essential role in HGF-induced cell scattering and implicates Fes in the cross-talk between cell-cell and cell-matrix adhesion.	Iron	66-69	ezrin	Homo sapiens	60-65
18046454-8	2008	Altogether, these results provide a novel mechanism whereby ezrin/Fes interaction at cell-cell contacts plays an essential role in HGF-induced cell scattering and implicates Fes in the cross-talk between cell-cell and cell-matrix adhesion.	Iron	174-177	ezrin	Homo sapiens	60-65
19066423-0	2008	Multi-organ iron overload in an African-American man with ALAS2 R452S and SLC40A1 R561G.	Iron	12-16	solute carrier family 40 member 1	Homo sapiens	74-81
19066423-11	2008	SLC40A1 R561G may have increased his iron absorption and overload further.	Iron	37-41	solute carrier family 40 member 1	Homo sapiens	0-7
18489257-3	2008	It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	45-53
18489257-5	2008	We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.	Iron	158-162	hepcidin antimicrobial peptide	Homo sapiens	72-80
18818166-6	2008	The strength of the relationship between hepcidin and ferritin was maintained in multiple linear regression analyses after enhancing the sample with data from women selected for low iron stores (n = 41).	Iron	182-186	hepcidin antimicrobial peptide	Homo sapiens	41-49
18818166-7	2008	Among pregnant women in a community-based study in rural Bangladesh, urinary hepcidin levels were related to iron status and AGP but not hemoglobin, erythropoietin, or C-reactive protein.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	77-85
19509462-7	2008	The IC50s for the iron chelation and DPPH scavenging assays were 153.8 +/- 26.3 microg x mL-1 and 7.53 +/- 0.71 microg x mL-1 (mean +/- SD), respectively.	Iron	18-22	L1 cell adhesion molecule	Mus musculus	89-102
19509462-7	2008	The IC50s for the iron chelation and DPPH scavenging assays were 153.8 +/- 26.3 microg x mL-1 and 7.53 +/- 0.71 microg x mL-1 (mean +/- SD), respectively.	Iron	18-22	L1 cell adhesion molecule	Mus musculus	89-93
17869549-1	2008	As the principal iron-regulatory hormone, hepcidin plays an important role in systemic iron homeostasis.	Iron	17-21	hepcidin antimicrobial peptide	Homo sapiens	42-50
17869549-2	2008	The regulation of hepcidin expression by iron loading appears to be unexpectedly complex and has attracted much interest.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	18-26
17869549-5	2008	The release of s-hemojuvelin is negatively regulated by both transferrin-bound iron (holo-Tf) and non-transferrin-bound iron (FAC), indicating s-hemojuvelin could be one of the mediators of hepcidin regulation by iron.	Iron	79-83	hemojuvelin BMP co-receptor	Homo sapiens	17-28
17869549-5	2008	The release of s-hemojuvelin is negatively regulated by both transferrin-bound iron (holo-Tf) and non-transferrin-bound iron (FAC), indicating s-hemojuvelin could be one of the mediators of hepcidin regulation by iron.	Iron	120-124	hemojuvelin BMP co-receptor	Homo sapiens	17-28
17869549-5	2008	The release of s-hemojuvelin is negatively regulated by both transferrin-bound iron (holo-Tf) and non-transferrin-bound iron (FAC), indicating s-hemojuvelin could be one of the mediators of hepcidin regulation by iron.	Iron	120-124	hemojuvelin BMP co-receptor	Homo sapiens	17-28
18022966-8	2008	The non-heme iron complexes [Fe(II)(PrL1)(2)](OTf)(2) (2) and [Fe(II)(PrL1)(2)](BPh(4))(2) (3) were tested in olefin oxidation reactions with H(2)O(2) as the terminal oxidant.	Iron	13-17	protein tyrosine phosphatase 4A1	Homo sapiens	36-40
18166790-2	2008	Hepcidin, a liver produced peptide hormone, is thought to be the central regulator of body iron metabolism.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
18166793-1	2008	Thalassemia associates anemia and iron overload, two opposite stimuli regulating hepcidin gene expression.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	81-89
19074074-0	2008	The regulation of hepcidin and its effects on systemic and cellular iron metabolism.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	18-26
19074074-1	2008	Systemic iron homeostasis depends on the regulated expression of hepcidin, a peptide hormone that negatively regulates iron egress from intestinal cells and macrophages by altering the expression of the cellular iron exporter ferroportin.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	65-73
19074074-1	2008	Systemic iron homeostasis depends on the regulated expression of hepcidin, a peptide hormone that negatively regulates iron egress from intestinal cells and macrophages by altering the expression of the cellular iron exporter ferroportin.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	65-73
19074074-1	2008	Systemic iron homeostasis depends on the regulated expression of hepcidin, a peptide hormone that negatively regulates iron egress from intestinal cells and macrophages by altering the expression of the cellular iron exporter ferroportin.	Iron	119-123	hepcidin antimicrobial peptide	Homo sapiens	65-73
19074074-2	2008	In doing so, hepcidin can control both the total body iron by modulating intestinal iron absorption as well as promote iron available for erythropoiesis by affecting the efficiency with which macrophages recycle iron from effete red blood cells.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	13-21
19074074-2	2008	In doing so, hepcidin can control both the total body iron by modulating intestinal iron absorption as well as promote iron available for erythropoiesis by affecting the efficiency with which macrophages recycle iron from effete red blood cells.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	13-21
19074074-2	2008	In doing so, hepcidin can control both the total body iron by modulating intestinal iron absorption as well as promote iron available for erythropoiesis by affecting the efficiency with which macrophages recycle iron from effete red blood cells.	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	13-21
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	22-26	ceruloplasmin	Mus musculus	106-119
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	22-26	ceruloplasmin	Mus musculus	121-123
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	176-180	ceruloplasmin	Mus musculus	106-119
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	176-180	ceruloplasmin	Mus musculus	121-123
18691669-0	2008	Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.	Iron	142-146	melanotransferrin	Homo sapiens	47-64
18336731-0	2008	Bovine lactoferrin inhibits the efficiency of invasion of respiratory A549 cells of different iron-regulated morphological forms of Pseudomonas aeruginosa and Burkholderia cenocepacia.	Iron	94-98	lactotransferrin	Bos taurus	7-18
18054440-1	2008	Recent findings indicate a principal role for Hepcidin in iron homeostasis.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	46-54
18054440-5	2008	Hepcidin is a peptide synthesised in the liver and is the main regulator of iron homeostasis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
18054440-10	2008	Current thinking is that defective Hepcidin synthesis or defective iron-sensing mechanisms leading to Hepcidin deficiency is the cause of iron overload in HFE-Haemochromatosis.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	102-110
18054440-10	2008	Current thinking is that defective Hepcidin synthesis or defective iron-sensing mechanisms leading to Hepcidin deficiency is the cause of iron overload in HFE-Haemochromatosis.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	35-43
18054440-10	2008	Current thinking is that defective Hepcidin synthesis or defective iron-sensing mechanisms leading to Hepcidin deficiency is the cause of iron overload in HFE-Haemochromatosis.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	102-110
18054440-14	2008	We propose that the defect in HFE-Haemochromatosis is the loss of Hepcidin surge in response to intake of dietary iron and is not as a result of reduced synthesis.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	66-74
18585086-4	2008	Available data also suggest that the iron released from NM affects the ubiquitin-proteasome system in mitochondria, leading to the failure to clear proteins such as alpha-synuclein and to the development of abnormal alpha-synuclein-immunopositive Lewy bodies that contribute to dopaminergic nerve cell death in PD.	Iron	37-41	synuclein alpha	Homo sapiens	165-180
18585086-4	2008	Available data also suggest that the iron released from NM affects the ubiquitin-proteasome system in mitochondria, leading to the failure to clear proteins such as alpha-synuclein and to the development of abnormal alpha-synuclein-immunopositive Lewy bodies that contribute to dopaminergic nerve cell death in PD.	Iron	37-41	synuclein alpha	Homo sapiens	216-231
19107209-13	2008	Longitudinal and mechanistic studies of IDA will further elucidate the role of hepcidin in paediatric iron regulation.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	79-87
18634255-5	2008	Between 2000-2004 other genes involved in iron homeostasis were intensively studied, leading to recognition of hepcidin (HAMP) - the most important iron hormone, hemojuvelin (HJV), transferin receptor 2 (TfR2) and ferroportin.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	111-119
18634255-5	2008	Between 2000-2004 other genes involved in iron homeostasis were intensively studied, leading to recognition of hepcidin (HAMP) - the most important iron hormone, hemojuvelin (HJV), transferin receptor 2 (TfR2) and ferroportin.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	121-125
18634255-5	2008	Between 2000-2004 other genes involved in iron homeostasis were intensively studied, leading to recognition of hepcidin (HAMP) - the most important iron hormone, hemojuvelin (HJV), transferin receptor 2 (TfR2) and ferroportin.	Iron	42-46	hemojuvelin BMP co-receptor	Homo sapiens	162-173
18634255-5	2008	Between 2000-2004 other genes involved in iron homeostasis were intensively studied, leading to recognition of hepcidin (HAMP) - the most important iron hormone, hemojuvelin (HJV), transferin receptor 2 (TfR2) and ferroportin.	Iron	42-46	hemojuvelin BMP co-receptor	Homo sapiens	175-178
18634255-5	2008	Between 2000-2004 other genes involved in iron homeostasis were intensively studied, leading to recognition of hepcidin (HAMP) - the most important iron hormone, hemojuvelin (HJV), transferin receptor 2 (TfR2) and ferroportin.	Iron	42-46	transferrin receptor 2	Homo sapiens	181-202
18634255-5	2008	Between 2000-2004 other genes involved in iron homeostasis were intensively studied, leading to recognition of hepcidin (HAMP) - the most important iron hormone, hemojuvelin (HJV), transferin receptor 2 (TfR2) and ferroportin.	Iron	42-46	transferrin receptor 2	Homo sapiens	204-208
18634255-7	2008	Hepcidin plays a central role in mobilization of iron, HFE, TfR2 and HJV playing a modulating role in its production, related to the body"s iron status.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
18634255-7	2008	Hepcidin plays a central role in mobilization of iron, HFE, TfR2 and HJV playing a modulating role in its production, related to the body"s iron status.	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	0-8
18634255-7	2008	Hepcidin plays a central role in mobilization of iron, HFE, TfR2 and HJV playing a modulating role in its production, related to the body"s iron status.	Iron	140-144	hemojuvelin BMP co-receptor	Homo sapiens	69-72
18634255-8	2008	It has also been demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	35-39
17942369-4	2008	Accumulation of iron within primary lesions was preceded by an increase in expression of heavy chain (H) ferritin, lactoferrin and receptors for transferrin, primarily by macrophages and granulocytes.	Iron	16-20	inhibitor of carbonic anhydrase	Cavia porcellus	145-156
17724144-0	2007	Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	8-16
17724144-1	2007	Inadequate hepcidin synthesis leads to iron overload in HFE-related hemochromatosis.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	11-19
17724144-2	2007	We explored the regulation of hepcidin by iron in 88 hemochromatosis patients (61 C282Y/C282Y, 27 C282Y/H63D) and 23 healthy controls by analyzing urinary hepcidin before and 24 hours after a 65-mg oral iron dose.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	30-38
17724144-2	2007	We explored the regulation of hepcidin by iron in 88 hemochromatosis patients (61 C282Y/C282Y, 27 C282Y/H63D) and 23 healthy controls by analyzing urinary hepcidin before and 24 hours after a 65-mg oral iron dose.	Iron	203-207	hepcidin antimicrobial peptide	Homo sapiens	30-38
17724144-5	2007	However, the hepcidin/ferritin ratio was decreased in both homozygotes (P &lt; .001) and heterozygotes (P = .017), confirming the inadequate hepcidin production for the iron load with both genotypes.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	141-149
17724144-6	2007	In iron-depleted patients of both genotypes studied at a time remote from phlebotomy, basal hepcidin was still lower than in controls (P &lt; .001 for C282Y/C282Y and P = .002 for heterozygotes).	Iron	3-7	hepcidin antimicrobial peptide	Homo sapiens	92-100
17724144-7	2007	After an iron challenge, mean urinary hepcidin excretion increased in controls (P = .001) but not patients, irrespective of genotype and iron status.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	38-46
17724144-9	2007	The hepcidin response to oral iron is blunted in HFE-related hemochromatosis and not improved after iron depletion.	Iron	30-34	hepcidin antimicrobial peptide	Homo sapiens	4-12
17724144-10	2007	The findings support the involvement of HFE in iron sensing and subsequent regulation of hepcidin.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	89-97
18297887-5	2007	Hepcidin, a small peptide synthesized by the liver, can sense iron stores and regulates iron transport by inhibition of ferroportin.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	0-8
18297887-5	2007	Hepcidin, a small peptide synthesized by the liver, can sense iron stores and regulates iron transport by inhibition of ferroportin.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	0-8
17516501-0	2007	Development and iron-dependent expression of hephaestin in different brain regions of rats.	Iron	16-20	hephaestin	Rattus norvegicus	45-55
17516501-1	2007	It has been suggested that Hephaestin (Heph), a newly discovered ceruloplasmin homologue, is necessary for iron egress from the enterocytes into circulation via interacting with ferroportin1 (FP1).	Iron	107-111	hephaestin	Rattus norvegicus	27-37
17516501-1	2007	It has been suggested that Hephaestin (Heph), a newly discovered ceruloplasmin homologue, is necessary for iron egress from the enterocytes into circulation via interacting with ferroportin1 (FP1).	Iron	107-111	hephaestin	Rattus norvegicus	27-31
17516501-2	2007	Based on the putative function of Heph, and the similarity between the process of iron transport in the enterocytes and that in the blood-brain barrier (BBB) cells, it has also been proposed that Heph plays a similar role in exporting iron from the BBB cells and other brain cells as it works in the enterocytes via interacting with FP1.	Iron	82-86	hephaestin	Rattus norvegicus	196-200
17516501-2	2007	Based on the putative function of Heph, and the similarity between the process of iron transport in the enterocytes and that in the blood-brain barrier (BBB) cells, it has also been proposed that Heph plays a similar role in exporting iron from the BBB cells and other brain cells as it works in the enterocytes via interacting with FP1.	Iron	235-239	hephaestin	Rattus norvegicus	196-200
18025230-5	2007	Fe chelation inhibits TNF-driven transcription of Vcam-1, Icam-1, and E-selectin, as assessed using luciferase reporter assays.	Iron	0-2	vascular cell adhesion molecule 1	Mus musculus	50-56
17968589-2	2007	To elucidate whether the signal regulates iron uptake genes in roots positively or negatively, we analyzed the expressions of two representative iron uptake genes: NtIRT1 and NtFRO1 in tobacco (Nicotiana tabacum L.) roots, after shoots were manipulated in vitro.	Iron	145-149	probable zinc transporter 10	Nicotiana tabacum	164-170
17968589-8	2007	Interestingly, the NtIRT1 expression in hairy roots increased under the iron-deficient condition, suggesting that roots also have the signaling mechanism of iron status as well as shoots.	Iron	72-76	probable zinc transporter 10	Nicotiana tabacum	19-25
17968589-8	2007	Interestingly, the NtIRT1 expression in hairy roots increased under the iron-deficient condition, suggesting that roots also have the signaling mechanism of iron status as well as shoots.	Iron	157-161	probable zinc transporter 10	Nicotiana tabacum	19-25
17968589-9	2007	Taken together, these results indicate that the long-distance signal generated in iron-deficient tissues including roots is a major factor in positive regulation of the expression of NtIRT1 and NtFRO1 in roots, and that the strength of the signal depends on the size of plants.	Iron	82-86	probable zinc transporter 10	Nicotiana tabacum	183-189
17994470-8	2007	The finding that serum and urinary pro-hepcidin is significantly increased in Wilson"s disease patients compared with healthy volunteers suggests a role for hepcidin in iron metabolism in Wilson"s disease, but this needs to be confirmed by a study of hepatic hepcidin expression in these patients.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	157-165
17994470-8	2007	The finding that serum and urinary pro-hepcidin is significantly increased in Wilson"s disease patients compared with healthy volunteers suggests a role for hepcidin in iron metabolism in Wilson"s disease, but this needs to be confirmed by a study of hepatic hepcidin expression in these patients.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	157-165
17936184-6	2007	Remarkably, caspase-9 activation and the ensuing caspase cascade proceeded normally in the presence of H2O2 under conditions of iron deprivation, indicating that the inhibition of procaspase-9 activation was an iron-dependent process.	Iron	128-132	caspase 9	Homo sapiens	12-21
17936184-6	2007	Remarkably, caspase-9 activation and the ensuing caspase cascade proceeded normally in the presence of H2O2 under conditions of iron deprivation, indicating that the inhibition of procaspase-9 activation was an iron-dependent process.	Iron	128-132	caspase 9	Homo sapiens	12-19
17936184-6	2007	Remarkably, caspase-9 activation and the ensuing caspase cascade proceeded normally in the presence of H2O2 under conditions of iron deprivation, indicating that the inhibition of procaspase-9 activation was an iron-dependent process.	Iron	211-215	caspase 9	Homo sapiens	12-21
17936184-6	2007	Remarkably, caspase-9 activation and the ensuing caspase cascade proceeded normally in the presence of H2O2 under conditions of iron deprivation, indicating that the inhibition of procaspase-9 activation was an iron-dependent process.	Iron	211-215	caspase 9	Homo sapiens	12-19
17978466-4	2007	Very recently, this cytokine has been found to enhance the synthesis of a peptide called hepcidin in the liver which regulates iron recycling, resulting in anemia due to hypofferemia.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	89-97
18025284-3	2007	In addition, anti-hTfR IgG3-Av alone exhibits intrinsic cytotoxic activity and interferes with hTfR recycling, leading to the rapid degradation of the TfR and lethal iron deprivation in certain malignant B-cell lines.	Iron	166-170	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	23-27
17551833-5	2007	They store iron efficiently in ferritin and can export iron by a mechanism that involves ferroportin and ceruloplasmin.	Iron	55-59	ceruloplasmin	Homo sapiens	105-118
17473933-10	2007	Despite the importance of hepcidin, there is evidence of hepcidin-independent regulation of iron absorption possibly involving haemojuvelin (HJV) and neogenin, which may be up-regulated during ineffective erythropoiesis.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	57-65
17473933-10	2007	Despite the importance of hepcidin, there is evidence of hepcidin-independent regulation of iron absorption possibly involving haemojuvelin (HJV) and neogenin, which may be up-regulated during ineffective erythropoiesis.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	127-139
17473933-10	2007	Despite the importance of hepcidin, there is evidence of hepcidin-independent regulation of iron absorption possibly involving haemojuvelin (HJV) and neogenin, which may be up-regulated during ineffective erythropoiesis.	Iron	92-96	hemojuvelin BMP co-receptor	Homo sapiens	141-144
17921041-9	2007	Mice with targeted mutation of the iron exporter ceruloplasmin have age-dependent retinal iron overload and a resulting retinal degeneration with features of age-related macular degeneration (AMD).	Iron	35-39	ceruloplasmin	Mus musculus	49-62
17921041-9	2007	Mice with targeted mutation of the iron exporter ceruloplasmin have age-dependent retinal iron overload and a resulting retinal degeneration with features of age-related macular degeneration (AMD).	Iron	90-94	ceruloplasmin	Mus musculus	49-62
17719162-1	2007	Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	4-8	solute carrier family 11 member 2	Homo sapiens	203-231
17719162-1	2007	Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	4-8	solute carrier family 11 member 2	Homo sapiens	233-237
17719162-1	2007	Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	243-256
17719162-1	2007	Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	258-262
17914866-10	2007	Whether His18-Fe-His33 coordination actually facilitates fast secondary structure formation or just slows folding less than His18-Fe-His26 coordination is probed by examining the double histidine mutant H26QH33N of horse heart cytochrome c.	Iron	130-132	cytochrome c, somatic	Equus caballus	227-239
17915953-2	2007	In the process of heme degradation, HO-1 receives the electrons necessary for catalysis from the flavoprotein NADPH cytochrome P450 reductase (CPR), releasing free iron and carbon monoxide.	Iron	164-168	heme oxygenase 1	Homo sapiens	36-40
17947579-4	2007	We demonstrate that the Jumonji domain-containing 6 protein (JMJD6) is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3) in both biochemical and cell-based assays.	Iron	89-93	jumonji domain containing 6	Mus musculus	61-66
17854133-8	2007	For example, hepcidin, a circulatory antimicrobial peptide synthesized by the hepatocytes of the liver is now known to play a central role in the regulation of iron homeostasis.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	13-21
17847004-10	2007	This first reported association between common variants in the BMP pathway and iron burden suggests that full expression of HFE hemochromatosis is linked to abnormal liver expression of hepcidin, not only through impairment in the HFE function but also through functional modulation in the BMP pathway.	Iron	79-83	bone morphogenetic protein 1	Homo sapiens	63-66
17847004-10	2007	This first reported association between common variants in the BMP pathway and iron burden suggests that full expression of HFE hemochromatosis is linked to abnormal liver expression of hepcidin, not only through impairment in the HFE function but also through functional modulation in the BMP pathway.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	186-194
17854319-1	2007	Hepcidin is a major regulator of iron homeostasis.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	0-8
17881647-0	2007	Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?	Iron	106-110	endothelial PAS domain protein 1	Homo sapiens	94-105
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	60-64	melanotransferrin	Homo sapiens	23-26
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	60-64	melanotransferrin	Homo sapiens	30-47
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	60-64	melanotransferrin	Homo sapiens	49-52
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	66-68	melanotransferrin	Homo sapiens	23-26
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	66-68	melanotransferrin	Homo sapiens	30-47
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	66-68	melanotransferrin	Homo sapiens	49-52
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	49-53
17660359-7	2007	Genetic analysis suggests that the secreted proteins FEA1 and FEA2 facilitate high-affinity iron uptake, perhaps by concentrating iron in the vicinity of the cell.	Iron	92-96	uncharacterized protein	Chlamydomonas reinhardtii	53-57
17660359-7	2007	Genetic analysis suggests that the secreted proteins FEA1 and FEA2 facilitate high-affinity iron uptake, perhaps by concentrating iron in the vicinity of the cell.	Iron	130-134	uncharacterized protein	Chlamydomonas reinhardtii	53-57
17660359-8	2007	Homologues of FEA1 and FRE1 were identified previously as high-CO(2)-responsive genes, HCR1 and HCR2, in Chlorococcum littorale, suggesting that components of the iron assimilation pathway are responsive to carbon nutrition.	Iron	163-167	uncharacterized protein	Chlamydomonas reinhardtii	14-18
17660359-8	2007	Homologues of FEA1 and FRE1 were identified previously as high-CO(2)-responsive genes, HCR1 and HCR2, in Chlorococcum littorale, suggesting that components of the iron assimilation pathway are responsive to carbon nutrition.	Iron	163-167	uncharacterized protein	Chlamydomonas reinhardtii	23-27
17886335-3	2007	The defining characteristic of this subset is failure to prevent unneeded iron from entering the circulatory pool as a result of genetic changes compromising the synthesis or activity of hepcidin, the iron hormone.	Iron	201-205	hepcidin antimicrobial peptide	Homo sapiens	187-195
17681937-2	2007	In this report we quantify the import-export balance in the vacuole because of the import of iron by Ccc1p and to export by the combined activity of Smf3p and the ferroxidase, permease pair of proteins, Fet5p and Fth1p.	Iron	93-97	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	149-154
17681937-5	2007	Using a combination of flameless atomic absorption spectrophotometry to quantify vacuolar and whole cell iron content and a reporter assay for cytoplasmic iron we demonstrate that Fre6p supplies Fe(II) to both efflux systems, while Fre7p plays no role in Fe-efflux from the vacuole.	Iron	195-197	putative ferric-chelate reductase	Saccharomyces cerevisiae S288C	232-237
17729391-4	2007	Furthermore, hepcidin, antimicrobial peptide produced mainly in the liver is also responsible for intestinal iron absorption and reticuloendothelial iron release.	Iron	109-113	hepcidin antimicrobial peptide	Homo sapiens	13-21
17729391-4	2007	Furthermore, hepcidin, antimicrobial peptide produced mainly in the liver is also responsible for intestinal iron absorption and reticuloendothelial iron release.	Iron	149-153	hepcidin antimicrobial peptide	Homo sapiens	13-21
17729393-2	2007	In the diet, iron is present in a number of different forms, generally described as haem (from haemoglobin and myoglobin in animal tissue) and non-haem iron (including ferric oxides and salts, ferritin and lactoferrin).	Iron	13-17	myoglobin	Homo sapiens	111-120
17729395-4	2007	It achieves this by secreting a peptide hormone called hepcidin that acts on the small intestinal epithelium and other cells to limit iron delivery to the plasma.	Iron	134-138	hepcidin antimicrobial peptide	Homo sapiens	55-63
17729395-5	2007	Hepcidin itself is regulated in response to various systemic stimuli including variations in body iron stores, the rate of erythropoiesis, inflammation and hypoxia, the same stimuli that have been known for many years to modulate iron absorption.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
17729395-5	2007	Hepcidin itself is regulated in response to various systemic stimuli including variations in body iron stores, the rate of erythropoiesis, inflammation and hypoxia, the same stimuli that have been known for many years to modulate iron absorption.	Iron	230-234	hepcidin antimicrobial peptide	Homo sapiens	0-8
17729395-6	2007	This review will summarize recent findings on the role played by the liver and hepcidin in the regulation of body iron absorption.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	79-87
17540841-0	2007	Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	27-35
17540841-0	2007	Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.	Iron	0-4	hemojuvelin BMP co-receptor	Homo sapiens	84-95
17540841-1	2007	The peptide hormone hepcidin is the principal regulator of systemic iron homeostasis.	Iron	68-72	hepcidin antimicrobial peptide	Homo sapiens	20-28
17540841-2	2007	We examined the pathway by which iron stimulates the production of hepcidin.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	67-75
17540841-3	2007	In humans who ingested 65 mg of iron, the increase in transferrin saturation preceded by hours the increase in urinary hepcidin excretion.	Iron	32-36	hepcidin antimicrobial peptide	Homo sapiens	119-127
17540841-5	2007	Paradoxically, in previous studies in primary hepatocytes and cell lines, hepcidin response to iron or iron transferrin was not observed.	Iron	95-99	hepcidin antimicrobial peptide	Homo sapiens	74-82
17766439-0	2007	Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins.	Iron	63-67	CDGSH iron sulfur domain 1	Homo sapiens	27-35
17490902-1	2007	The ferroportin polymorphism SLC40A1 Q248H (exon 6, cDNA 744G--&gt;T; Gln248His) occurs in persons of sub-Saharan African descent with and without iron overload, and is associated with elevated serum ferritin concentrations (SF).	Iron	147-151	solute carrier family 40 member 1	Homo sapiens	29-36
17720947-1	2007	Hepcidin has emerged as the key hormone in the regulation of iron balance and recycling.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	0-8
17720947-3	2007	The physiology of hepcidin suggests an additional mechanism by which iron depletion could protect against atherosclerotic lesion progression.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	18-26
17720947-8	2007	Hepcidin may promote plaque destabilization by preventing iron mobilization from macrophages within atherosclerotic lesions; the absence of this mobilization may result in increased cellular iron loads, lipid peroxidation, and progression to foam cells.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
17720947-9	2007	Marked downregulation of hepcidin (e.g., by induction of iron deficiency anemia) could accelerate iron loss from intralesional macrophages.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	25-33
17569621-7	2007	Upon organ transplantation, HO-1 is ubiquitously expressed in a transplanted organ, becoming the rate-limiting enzyme in the catabolism of heme into carbon monoxide (CO), iron (Fe) and biliverdin (1).	Iron	171-175	heme oxygenase 1	Homo sapiens	28-32
17569621-7	2007	Upon organ transplantation, HO-1 is ubiquitously expressed in a transplanted organ, becoming the rate-limiting enzyme in the catabolism of heme into carbon monoxide (CO), iron (Fe) and biliverdin (1).	Iron	177-179	heme oxygenase 1	Homo sapiens	28-32
17559363-4	2007	Hepcidin is a recently characterized molecule that appears to play a key role in the regulation of iron efflux from enterocytes, macrophages, and hepatocytes.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	0-8
17590401-9	2007	Surprisingly, although mRNA levels for the HSPs were not altered by iron, the abundance of Hsp25, Hsp70 and Hsp90 proteins was uniformly reduced in the iron-loaded livers, as were levels of NAD(P)H:quinone oxidoreductase 1, an Hsp70 client protein.	Iron	152-156	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	98-103
17590401-9	2007	Surprisingly, although mRNA levels for the HSPs were not altered by iron, the abundance of Hsp25, Hsp70 and Hsp90 proteins was uniformly reduced in the iron-loaded livers, as were levels of NAD(P)H:quinone oxidoreductase 1, an Hsp70 client protein.	Iron	152-156	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	227-232
17726528-4	2007	The ATP-binding cassette (ABC) transporters ABCB6 and ABCB7 are also involved in iron homeostasis.	Iron	81-85	ATP binding cassette subfamily B member 7	Homo sapiens	54-59
17584744-5	2007	Although the CDGSH domain is annotated as a zinc finger motif, mitoNEET was shown to contain iron (Wiley, S. E., Murphy, A. N., Ross, S. A., van der Geer, P., and Dixon, J. E. (2007) Proc.	Iron	93-97	CDGSH iron sulfur domain 1	Homo sapiens	63-71
17584744-16	2007	Based on the biophysical data and domain fusion analysis, mitoNEET may function in Fe-S cluster shuttling and/or in redox reactions.	Iron	83-87	CDGSH iron sulfur domain 1	Homo sapiens	58-66
17307325-2	2007	The absence of ceruloplasmin and its ferroxidase activity leads to pathological iron overload in the brain and other organs.	Iron	80-84	ceruloplasmin	Homo sapiens	15-28
17562347-9	2007	Our finding implicates functional importance of histidine in exchange of arginine at amino acid 481 of transferrin receptor 2 in iron homeostasis.	Iron	129-133	transferrin receptor 2	Homo sapiens	103-125
17675795-1	2007	Bovine lactoferrin (bLf) is an iron-binding secretory protein present in breast milk, mucosal secretions, and the secondary granules of neutrophils.	Iron	31-35	lactotransferrin	Rattus norvegicus	7-18
17517886-0	2007	Functional characterization of AtATM1, AtATM2, and AtATM3, a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis.	Iron	148-152	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	51-57
17517886-2	2007	Designated AtATM1, AtAATM2, and AtATM3, these half-molecule ABC proteins are homologous to the yeast mitochondrial membrane protein ATM1 (ScATM1), which is clearly implicated in the export of mitochondrially synthesized iron/sulfur clusters.	Iron	220-224	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	32-38
17517886-5	2007	Heterologously expressed AtATM3 is not only able to complement the yeast atm1 petite phenotype but is also able to suppress the constitutively high capacity for high affinity iron uptake associated with loss of the chromosomal copy of ScATM1, abrogate intra-mitochondrial iron hyperaccumulation, and restore mitochondrial respiratory function and cytochrome c levels.	Iron	175-179	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	25-31
17517886-5	2007	Heterologously expressed AtATM3 is not only able to complement the yeast atm1 petite phenotype but is also able to suppress the constitutively high capacity for high affinity iron uptake associated with loss of the chromosomal copy of ScATM1, abrogate intra-mitochondrial iron hyperaccumulation, and restore mitochondrial respiratory function and cytochrome c levels.	Iron	272-276	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	25-31
17531952-3	2007	In the present study, we investigated the stoichiometry of binding of copper [Cu (II)] and iron [Fe (III)] with alpha-synuclein (wild recombinant type and A30P, A53T, E46K mutant forms) using isothermal titration calorimetry (ITC).	Iron	91-95	synuclein alpha	Homo sapiens	112-127
17611542-10	2007	These results provide a structural framework for understanding the mechanism of disulphide reduction by an iron-sulphur enzyme and describe previously unknown interaction networks for both Fdx and Trx (refs 4-6).	Iron	107-111	thioredoxin	Homo sapiens	197-200
17428703-2	2007	Among these proteins, it was discovered a second transferrin receptor (TfR2), that seems to play a key role in the regulation of iron homeostasis.	Iron	129-133	transferrin receptor 2	Homo sapiens	71-75
17428703-7	2007	Experiments of in vitro iron loading or iron deprivation provided evidence that TfR2 is modulated in cancer cell lines according to cellular iron levels following two different mechanisms: (i) in some cells, iron loading caused a downmodulation of total TfR2 levels; (ii) in other cell types, iron loading caused a downmodulation of membrane-bound TfR2, without affecting the levels of total cellular TfR2 content.	Iron	24-28	transferrin receptor 2	Homo sapiens	80-84
17428703-7	2007	Experiments of in vitro iron loading or iron deprivation provided evidence that TfR2 is modulated in cancer cell lines according to cellular iron levels following two different mechanisms: (i) in some cells, iron loading caused a downmodulation of total TfR2 levels; (ii) in other cell types, iron loading caused a downmodulation of membrane-bound TfR2, without affecting the levels of total cellular TfR2 content.	Iron	40-44	transferrin receptor 2	Homo sapiens	80-84
17428703-7	2007	Experiments of in vitro iron loading or iron deprivation provided evidence that TfR2 is modulated in cancer cell lines according to cellular iron levels following two different mechanisms: (i) in some cells, iron loading caused a downmodulation of total TfR2 levels; (ii) in other cell types, iron loading caused a downmodulation of membrane-bound TfR2, without affecting the levels of total cellular TfR2 content.	Iron	40-44	transferrin receptor 2	Homo sapiens	80-84
17428703-7	2007	Experiments of in vitro iron loading or iron deprivation provided evidence that TfR2 is modulated in cancer cell lines according to cellular iron levels following two different mechanisms: (i) in some cells, iron loading caused a downmodulation of total TfR2 levels; (ii) in other cell types, iron loading caused a downmodulation of membrane-bound TfR2, without affecting the levels of total cellular TfR2 content.	Iron	40-44	transferrin receptor 2	Homo sapiens	80-84
17607352-1	2007	Hepcidin is a peptide hormone secreted by the liver that plays a central role in the regulation of iron homeostasis.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	0-8
17607352-6	2007	Administration of a recombinant, soluble form of HJV decreased hepcidin expression and increased serum iron levels by mobilizing iron from splenic stores.	Iron	103-107	hemojuvelin BMP co-receptor	Homo sapiens	49-52
17607352-6	2007	Administration of a recombinant, soluble form of HJV decreased hepcidin expression and increased serum iron levels by mobilizing iron from splenic stores.	Iron	129-133	hemojuvelin BMP co-receptor	Homo sapiens	49-52
17607365-0	2007	Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance.	Iron	78-82	bone morphogenetic protein 1	Homo sapiens	14-40
17607365-1	2007	Systemic iron balance is regulated by hepcidin, a peptide hormone secreted by the liver.	Iron	9-13	hepcidin antimicrobial peptide	Homo sapiens	38-46
17607365-2	2007	By decreasing cell surface expression of the iron exporter ferroportin, hepcidin decreases iron absorption from the intestine and iron release from reticuloendothelial stores.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	72-80
17579077-11	2007	The iron regulatory peptide hepcidin was also expressed but was not associated with maternal anemia.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
17695374-0	2007	Steap proteins: implications for iron and copper metabolism.	Iron	33-37	STEAP family member 1	Homo sapiens	0-5
17695374-3	2007	Further characterization of Steap3 and other Steap proteins reveals a possible greater role of Steap proteins in iron and copper metabolism.	Iron	113-117	STEAP family member 1	Homo sapiens	28-33
17695374-3	2007	Further characterization of Steap3 and other Steap proteins reveals a possible greater role of Steap proteins in iron and copper metabolism.	Iron	113-117	STEAP family member 1	Homo sapiens	45-50
17452319-0	2007	Characterization of Arabidopsis thaliana SufE2 and SufE3: functions in chloroplast iron-sulfur cluster assembly and Nad synthesis.	Iron	83-87	quinolinate synthase	Arabidopsis thaliana	51-56
17273818-3	2007	This iron donation is highly regulated and the liver-derived peptide hepcidin has emerged as the key modulator of cellular iron export.	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	69-77
17273818-3	2007	This iron donation is highly regulated and the liver-derived peptide hepcidin has emerged as the key modulator of cellular iron export.	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	69-77
17273818-4	2007	Following its synthesis and secretion from the liver, circulating hepcidin reduces iron export into the plasma by binding to the iron efflux protein ferroportin1 on the surface of enterocytes, macrophages and other cell types and causing its internalization.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	66-74
17273818-4	2007	Following its synthesis and secretion from the liver, circulating hepcidin reduces iron export into the plasma by binding to the iron efflux protein ferroportin1 on the surface of enterocytes, macrophages and other cell types and causing its internalization.	Iron	83-87	solute carrier family 40 member 1	Homo sapiens	149-161
17273818-4	2007	Following its synthesis and secretion from the liver, circulating hepcidin reduces iron export into the plasma by binding to the iron efflux protein ferroportin1 on the surface of enterocytes, macrophages and other cell types and causing its internalization.	Iron	129-133	hepcidin antimicrobial peptide	Homo sapiens	66-74
17273818-4	2007	Following its synthesis and secretion from the liver, circulating hepcidin reduces iron export into the plasma by binding to the iron efflux protein ferroportin1 on the surface of enterocytes, macrophages and other cell types and causing its internalization.	Iron	129-133	solute carrier family 40 member 1	Homo sapiens	149-161
17273818-8	2007	In addition to being regulated by body iron requirements, hepcidin expression can be modulated by pro-inflammatory cytokines such as interleukin-6.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	58-66
17533042-0	2007	Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	77-81
17533042-8	2007	CONCLUSION: These results suggest that IRP-1/IRE interactions, which are supposedly induced after sensing a decrease of the intracellular non-Heme iron levels, play a crucial role on the posttranscriptional regulation of TfR, DMT1, and ferritin mRNAs during differentiation of normal human erythropoietic cells.	Iron	147-151	solute carrier family 11 member 2	Homo sapiens	226-230
17475338-11	2007	We conclude that most of the iron in fibroblast HMF from both affected and unaffected cells is ferrihydrite but only FRDA affected cells mineralize significant iron in mitochondrial ferritin.	Iron	160-164	ferritin mitochondrial	Homo sapiens	168-190
17601319-1	2007	Discovery of iron-regulating hormone hepcidin gives new explanations].	Iron	13-17	hepcidin antimicrobial peptide	Homo sapiens	37-45
17264300-1	2007	Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload.	Iron	43-47	hemojuvelin BMP co-receptor	Homo sapiens	0-11
17264300-1	2007	Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload.	Iron	43-47	hemojuvelin BMP co-receptor	Homo sapiens	13-16
17264300-1	2007	Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	58-66
17264300-1	2007	Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload.	Iron	171-175	hemojuvelin BMP co-receptor	Homo sapiens	0-11
17264300-1	2007	Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload.	Iron	171-175	hemojuvelin BMP co-receptor	Homo sapiens	13-16
17403714-3	2007	Both children were compound heterozygotes for novel mutations in the human bc1 synthesis like (BCS1L) gene, which encodes an AAA mitochondrial protein putatively involved in both iron homeostasis and complex III assembly.	Iron	179-183	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	95-100
18214023-2	2007	Recent observations have demonstrated that a peptide hormone, hepcidin, is the principal regulator of iron homeostasis.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	62-70
18214023-5	2007	Hepcidin restricts both iron absorption and iron release from stores.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	0-8
18214023-5	2007	Hepcidin restricts both iron absorption and iron release from stores.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
18214023-7	2007	Hepcidin secretion is suppressed by accelerated erythropoiesis even when iron stores are increased.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	0-8
17401378-0	2007	The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol.	Iron	46-50	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	4-8
17401378-0	2007	The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol.	Iron	46-50	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	9-14
17401378-3	2007	So far, four highly conserved proteins (Cfd1, Nbp35, Nar1 and Cia1) have been identified as members of the cytosolic [Fe-S] protein assembly machinery, but their molecular function is unresolved.	Iron	118-122	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	40-44
17401378-3	2007	So far, four highly conserved proteins (Cfd1, Nbp35, Nar1 and Cia1) have been identified as members of the cytosolic [Fe-S] protein assembly machinery, but their molecular function is unresolved.	Iron	118-122	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	46-51
17468001-6	2007	Expression of CsHA1, CsFRO1 and CsIRT1 is diminished in Fe-deficient roots by treatment with ethylene inhibitors, like Co (cobalt) or AOA (aminooxyacetic acid).	Iron	56-58	plasma membrane ATPase 4	Cucumis sativus	14-19
17349976-1	2007	Hepcidin, a liver peptide, systemically inhibits iron utilization and is downregulated under hypoxic conditions.	Iron	49-53	hepcidin antimicrobial peptide	Homo sapiens	0-8
17253959-4	2007	This new finding suggests that NgalR-3 may act as a potential NGAL receptor and play a role in NGAL-mediated iron transport in oesophageal carcinoma.	Iron	109-113	solute carrier family 22 member 17	Homo sapiens	31-38
17272487-1	2007	BACKGROUND: Discovery of the central role of hepcidin in body iron regulation has shed new light on the pathophysiology of iron disorders.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	45-53
17272487-10	2007	Preliminary studies showed that hepcidin-25 differentiated disorders of iron metabolism.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	32-40
17408452-8	2007	HO (inducible HO-1, constitutive HO-2 and HO-3) is the rate-limiting enzyme in haeme catabolism, which leads to the generation of biliverdin, iron, and carbon monoxide.	Iron	142-146	heme oxygenase 1	Homo sapiens	14-18
17367548-4	2007	The EELS results indicate that for both FeF3/C and FeF2/C nanocomposite systems, a complete reduction of iron to FeO is observed upon discharge to 1.5 V with the formation of a finer FeO/LiF subnanocomposite ( approximately 7 nm).	Iron	105-109	LIF interleukin 6 family cytokine	Homo sapiens	187-190
17182845-1	2007	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe(2)Tf).	Iron	105-109	transferrin receptor 2	Homo sapiens	0-22
17182845-1	2007	Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe(2)Tf).	Iron	105-109	transferrin receptor 2	Homo sapiens	24-28
17182845-2	2007	TfR2 also binds Fe(2)Tf, but it seems to function primarily in the regulation of systemic iron homeostasis.	Iron	90-94	transferrin receptor 2	Homo sapiens	0-4
17337631-0	2007	PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport.	Iron	64-68	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	0-4
17337631-0	2007	PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport.	Iron	64-68	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	17-25
17337631-6	2007	Knockout mutants of PIC1 grew only heterotrophically and were characterized by a chlorotic and dwarfish phenotype reminiscent of iron-deficient plants.	Iron	129-133	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	20-24
17337631-8	2007	Besides upregulation of ferritin, pic1 mutants showed differential regulation of genes and proteins related to iron stress or transport, photosynthesis, and Fe-S cluster biogenesis.	Iron	111-115	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	34-38
17337631-8	2007	Besides upregulation of ferritin, pic1 mutants showed differential regulation of genes and proteins related to iron stress or transport, photosynthesis, and Fe-S cluster biogenesis.	Iron	157-161	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	34-38
17337631-9	2007	Furthermore, PIC1 and its cyanobacterial homolog mediated iron accumulation in an iron uptake-defective yeast mutant.	Iron	58-62	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	13-17
17337631-9	2007	Furthermore, PIC1 and its cyanobacterial homolog mediated iron accumulation in an iron uptake-defective yeast mutant.	Iron	82-86	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	13-17
17337631-10	2007	These observations suggest that PIC1 functions in iron transport across the inner envelope of chloroplasts and hence in cellular metal homeostasis.	Iron	50-54	translocon at inner membrane of chloroplasts 21	Arabidopsis thaliana	32-36
17309777-0	2007	Iron ions and haeme modulate the binding properties of complement subcomponent C1q and of immunoglobulins.	Iron	0-4	complement C1q A chain	Homo sapiens	79-82
17309777-3	2007	The aim of this study was to analyse the consequences of the exposure of C1q and immunoglobulins to iron ions or haeme.	Iron	100-104	complement C1q A chain	Homo sapiens	73-76
17343447-4	2007	However, the magnetic coupling between the Co atoms remains ferromagnetic as it is between iron atoms supported on a coronene molecule.	Iron	91-95	complement C2	Homo sapiens	117-125
17172471-0	2007	Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages.	Iron	0-4	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	28-32
17172471-0	2007	Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages.	Iron	0-4	HRas proto-oncogene, GTPase	Homo sapiens	34-40
17172471-0	2007	Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages.	Iron	0-4	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	46-75
17172471-4	2007	IKK activation induced by iron is abrogated by overexpression of a dominant negative mutant (DN) for transforming growth factor beta-activated kinase-1 (TAK1), NF-kappaB-inducing kinase, or phosphatidylinositol 3-kinase (PI3K) and by treatment with the mitogen-activated protein kinase (MAPK) kinase-1 (MEK1) inhibitor.	Iron	26-30	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	101-151
17172471-4	2007	IKK activation induced by iron is abrogated by overexpression of a dominant negative mutant (DN) for transforming growth factor beta-activated kinase-1 (TAK1), NF-kappaB-inducing kinase, or phosphatidylinositol 3-kinase (PI3K) and by treatment with the mitogen-activated protein kinase (MAPK) kinase-1 (MEK1) inhibitor.	Iron	26-30	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	153-157
17172471-4	2007	IKK activation induced by iron is abrogated by overexpression of a dominant negative mutant (DN) for transforming growth factor beta-activated kinase-1 (TAK1), NF-kappaB-inducing kinase, or phosphatidylinositol 3-kinase (PI3K) and by treatment with the mitogen-activated protein kinase (MAPK) kinase-1 (MEK1) inhibitor.	Iron	26-30	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	190-219
17296847-9	2007	These observations raise the possibility that these cases of atypical neurodegeneration with brain iron accumulation represent a distinct clinicopathological syndrome and suggest a molecular link between iron deposition and alpha-synuclein accumulation.	Iron	99-103	synuclein alpha	Homo sapiens	224-239
17296847-9	2007	These observations raise the possibility that these cases of atypical neurodegeneration with brain iron accumulation represent a distinct clinicopathological syndrome and suggest a molecular link between iron deposition and alpha-synuclein accumulation.	Iron	204-208	synuclein alpha	Homo sapiens	224-239
17464355-1	2007	Mammals posses both serum transferrin and lactoferrin, whose functions are taken over in birds by ovotransferrin, displaying both iron transport and antibacterial activities.	Iron	130-134	transferrin (ovotransferrin)	Gallus gallus	98-112
17258727-0	2007	Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene.	Iron	43-47	ceruloplasmin	Mus musculus	68-81
17258727-5	2007	RESULTS: We identified 1 locus encompassing the Ceruloplasmin (Cp) gene with a strong linkage with liver iron, serum iron, and transferrin levels but not with spleen iron.	Iron	105-109	ceruloplasmin	Mus musculus	48-61
17258727-5	2007	RESULTS: We identified 1 locus encompassing the Ceruloplasmin (Cp) gene with a strong linkage with liver iron, serum iron, and transferrin levels but not with spleen iron.	Iron	117-121	ceruloplasmin	Mus musculus	48-61
17258727-5	2007	RESULTS: We identified 1 locus encompassing the Ceruloplasmin (Cp) gene with a strong linkage with liver iron, serum iron, and transferrin levels but not with spleen iron.	Iron	117-121	ceruloplasmin	Mus musculus	48-61
16932966-1	2007	The newly discovered proteins hemojuvelin (Hjv) and transferrin receptor type 2 (TfR2) are involved in iron metabolism.	Iron	103-107	hemojuvelin BMP co-receptor	Rattus norvegicus	30-41
16932966-1	2007	The newly discovered proteins hemojuvelin (Hjv) and transferrin receptor type 2 (TfR2) are involved in iron metabolism.	Iron	103-107	hemojuvelin BMP co-receptor	Rattus norvegicus	43-46
16932966-11	2007	The localization of Hjv and TfR2 at the same membrane domain renders a functional interaction of these two proteins in iron homeostasis possible.	Iron	119-123	hemojuvelin BMP co-receptor	Rattus norvegicus	20-23
17194590-4	2007	The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1.	Iron	73-77	solute carrier family 40 member 1	Homo sapiens	128-141
17194590-4	2007	The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	143-151
17194590-4	2007	The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1.	Iron	73-77	hemojuvelin BMP co-receptor	Homo sapiens	153-164
17194590-4	2007	The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1.	Iron	73-77	solute carrier family 46 member 1	Homo sapiens	169-191
17227084-5	2007	The iron saturation level of LF had no effect on the production of Lfcin.	Iron	4-8	lactotransferrin	Bos taurus	29-31
17227084-6	2007	Nevertheless, the digestion of LF containing lower iron content led to the production of a higher quantity of low molecular weight cationic peptides.	Iron	51-55	lactotransferrin	Bos taurus	31-33
17183171-0	2007	Preliminary X-ray diffraction analysis of YcdB from Escherichia coli: a novel haem-containing and Tat-secreted periplasmic protein with a potential role in iron transport.	Iron	156-160	YcdB	Escherichia coli	42-46
17183171-1	2007	YcdB is a periplasmic haem-containing protein from Escherichia coli that has a potential role in iron transport.	Iron	97-101	YcdB	Escherichia coli	0-4
17095719-4	2007	Three genes involved in iron-heme homeostasis, CD163, HO-1, and transferrin receptor, were further analyzed in 40 independent plaques.	Iron	24-28	heme oxygenase 1	Homo sapiens	54-84
17095719-6	2007	The expression of HO-1 and CD163 correlated with tissue iron content but iron itself was not associated with the symptom status.	Iron	56-60	heme oxygenase 1	Homo sapiens	18-22
17098454-1	2007	BACKGROUND: Individuals with pathogenic mutations in HFE, hemojuvelin (HJV) and transferrin receptor 2 (TfR2) have low levels of hepcidin, but little is known about the hepatic expression of these molecules in patients with physiological iron overload or HFE associated Hemochromatosis (HH).	Iron	238-242	hemojuvelin BMP co-receptor	Homo sapiens	58-69
17098454-1	2007	BACKGROUND: Individuals with pathogenic mutations in HFE, hemojuvelin (HJV) and transferrin receptor 2 (TfR2) have low levels of hepcidin, but little is known about the hepatic expression of these molecules in patients with physiological iron overload or HFE associated Hemochromatosis (HH).	Iron	238-242	hemojuvelin BMP co-receptor	Homo sapiens	71-74
17098454-1	2007	BACKGROUND: Individuals with pathogenic mutations in HFE, hemojuvelin (HJV) and transferrin receptor 2 (TfR2) have low levels of hepcidin, but little is known about the hepatic expression of these molecules in patients with physiological iron overload or HFE associated Hemochromatosis (HH).	Iron	238-242	transferrin receptor 2	Homo sapiens	80-102
17098454-1	2007	BACKGROUND: Individuals with pathogenic mutations in HFE, hemojuvelin (HJV) and transferrin receptor 2 (TfR2) have low levels of hepcidin, but little is known about the hepatic expression of these molecules in patients with physiological iron overload or HFE associated Hemochromatosis (HH).	Iron	238-242	transferrin receptor 2	Homo sapiens	104-108
17098454-6	2007	RESULTS: Physiological iron overload led to significantly upregulated hepcidin, HJV and ferroportin mRNA expression while TfR2 expression was not significantly different to controls.	Iron	23-27	hepcidin antimicrobial peptide	Homo sapiens	70-78
17098454-6	2007	RESULTS: Physiological iron overload led to significantly upregulated hepcidin, HJV and ferroportin mRNA expression while TfR2 expression was not significantly different to controls.	Iron	23-27	hemojuvelin BMP co-receptor	Homo sapiens	80-83
17098454-6	2007	RESULTS: Physiological iron overload led to significantly upregulated hepcidin, HJV and ferroportin mRNA expression while TfR2 expression was not significantly different to controls.	Iron	23-27	transferrin receptor 2	Homo sapiens	122-126
17910282-0	2007	Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease.	Iron	54-58	selectin P	Homo sapiens	28-38
17185532-0	2007	The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans.	Iron	4-8	suppression inducing transmembrane adaptor 1	Mus musculus	34-38
17185532-3	2007	In this study, C. neoformans mutants were constructed with a defect in the iron-regulated gene SIT1 that encodes a putative siderophore iron transporter.	Iron	75-79	suppression inducing transmembrane adaptor 1	Mus musculus	95-99
17185532-4	2007	Analysis of mutants in serotype A and D strains demonstrated that SIT1 is required for the use of siderophore-bound iron, and for growth in a low-iron environment.	Iron	116-120	suppression inducing transmembrane adaptor 1	Mus musculus	66-70
17185532-4	2007	Analysis of mutants in serotype A and D strains demonstrated that SIT1 is required for the use of siderophore-bound iron, and for growth in a low-iron environment.	Iron	146-150	suppression inducing transmembrane adaptor 1	Mus musculus	66-70
17515961-1	2007	Recently identified hepcidin, exclusively synthesized in the liver, is thought to be a key regulator for iron homeostasis and is induced by infection and inflammation.	Iron	105-109	hepcidin antimicrobial peptide	Homo sapiens	20-28
17515961-5	2007	Hepcidin expression levels were strongly correlated with serum ferritin (P &lt; 0.0001) and the degree of iron deposit in liver tissues (P &lt; 0.0001).	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
17515961-6	2007	Hepcidin was also correlated with hematological parameters (vs. hemoglobin, P = 0.0073; vs. serum iron, P = 0.0012; vs. transferrin saturation, P &lt; 0.0001) and transaminase levels (P = 0.0013).	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
17515961-8	2007	In conclusion, hepcidin expression levels in chronic liver diseases were strongly correlated with either the serum ferritin concentration or degree of iron deposits in the liver.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	15-23
17515961-9	2007	When adjusted by either serum ferritin values or hepatic iron scores, hepcidin indices were significantly lower in HCV(+) patients than in HBV(+) patients, suggesting that hepcidin may play a pivotal role in the pathogenesis of iron overload in patients with chronic hepatitis C.	Iron	228-232	hepcidin antimicrobial peptide	Homo sapiens	172-180
17507875-9	2007	CONCLUSION: These data suggest that the reduced conversion of NAD(P)H oxidase-generated O(2)- into H(2)- O(2)- and/or OH, which in turn synergistically enhanced pollen antigen-induced airway inflammation, is due to the iron-binding capacity of LF.	Iron	219-223	lactotransferrin	Mus musculus	244-246
18333366-0	2007	IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	16-24
18333366-1	2007	Recently discovered peptide hormone hepcidin is the key regulator of systemic iron homeostasis.	Iron	78-82	hepcidin antimicrobial peptide	Homo sapiens	36-44
18333366-2	2007	Iron metabolism is regulated in response to variations in hepcidin plasma levels.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	58-66
18333366-3	2007	Hepcidin levels that are inappropriately low or high result in iron overload or iron deficiency, respectively.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
18333366-4	2007	The early studies showed that hypoxia, iron concentration, and inflammation influence hepcidin levels, but the exact mechanism remained elusive.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	86-94
20020877-6	2007	For example, dietary iron uptake across the intestinal duodenal mucosa is mediated by an intramembrane divalent metal transporter 1 (DMT1), and cellular iron efflux involves ferroportin, the only known iron exporter.	Iron	21-25	solute carrier family 11 member 2	Homo sapiens	103-131
20020877-6	2007	For example, dietary iron uptake across the intestinal duodenal mucosa is mediated by an intramembrane divalent metal transporter 1 (DMT1), and cellular iron efflux involves ferroportin, the only known iron exporter.	Iron	21-25	solute carrier family 11 member 2	Homo sapiens	133-137
20020877-9	2007	These recent studies on the role of hepcidin in the regulation of dietary, cellular, and extracellular iron have led to a better understanding of the pathways by which iron balance in humans is influenced, especially its involvement in human genetic diseases of iron overload.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	36-44
20020877-9	2007	These recent studies on the role of hepcidin in the regulation of dietary, cellular, and extracellular iron have led to a better understanding of the pathways by which iron balance in humans is influenced, especially its involvement in human genetic diseases of iron overload.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	36-44
20020877-9	2007	These recent studies on the role of hepcidin in the regulation of dietary, cellular, and extracellular iron have led to a better understanding of the pathways by which iron balance in humans is influenced, especially its involvement in human genetic diseases of iron overload.	Iron	168-172	hepcidin antimicrobial peptide	Homo sapiens	36-44
20020877-13	2007	Given the importance of dietary iron in normal physiology, its potential to induce chronic toxicity, and recent discoveries in the regulation of human iron metabolism by hepcidin, this review will address the regulatory mechanisms of normal iron metabolism in mammals with emphasis on dietary exposure.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	170-178
20020877-13	2007	Given the importance of dietary iron in normal physiology, its potential to induce chronic toxicity, and recent discoveries in the regulation of human iron metabolism by hepcidin, this review will address the regulatory mechanisms of normal iron metabolism in mammals with emphasis on dietary exposure.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	170-178
17177551-0	2006	Myoglobin oxidation in a model system as affected by nonheme iron and iron chelating agents.	Iron	61-65	myoglobin	Homo sapiens	0-9
17177551-0	2006	Myoglobin oxidation in a model system as affected by nonheme iron and iron chelating agents.	Iron	70-74	myoglobin	Homo sapiens	0-9
17177551-1	2006	A model system was used to study the effect of nonheme iron on myoglobin oxidation at pH 5.6 and pH 7.2 at 23 degrees C. The addition of ferrous iron significantly (p &lt; 0.05) increased the rate of myoglobin oxidation in the absence of lipid, demonstrating that iron promoted myoglobin oxidation independent of the effect of lipid oxidation.	Iron	55-59	myoglobin	Homo sapiens	63-72
17177551-1	2006	A model system was used to study the effect of nonheme iron on myoglobin oxidation at pH 5.6 and pH 7.2 at 23 degrees C. The addition of ferrous iron significantly (p &lt; 0.05) increased the rate of myoglobin oxidation in the absence of lipid, demonstrating that iron promoted myoglobin oxidation independent of the effect of lipid oxidation.	Iron	145-149	myoglobin	Homo sapiens	63-72
17177551-1	2006	A model system was used to study the effect of nonheme iron on myoglobin oxidation at pH 5.6 and pH 7.2 at 23 degrees C. The addition of ferrous iron significantly (p &lt; 0.05) increased the rate of myoglobin oxidation in the absence of lipid, demonstrating that iron promoted myoglobin oxidation independent of the effect of lipid oxidation.	Iron	145-149	myoglobin	Homo sapiens	200-209
17177551-1	2006	A model system was used to study the effect of nonheme iron on myoglobin oxidation at pH 5.6 and pH 7.2 at 23 degrees C. The addition of ferrous iron significantly (p &lt; 0.05) increased the rate of myoglobin oxidation in the absence of lipid, demonstrating that iron promoted myoglobin oxidation independent of the effect of lipid oxidation.	Iron	145-149	myoglobin	Homo sapiens	200-209
17177551-1	2006	A model system was used to study the effect of nonheme iron on myoglobin oxidation at pH 5.6 and pH 7.2 at 23 degrees C. The addition of ferrous iron significantly (p &lt; 0.05) increased the rate of myoglobin oxidation in the absence of lipid, demonstrating that iron promoted myoglobin oxidation independent of the effect of lipid oxidation.	Iron	145-149	myoglobin	Homo sapiens	63-72
17177551-1	2006	A model system was used to study the effect of nonheme iron on myoglobin oxidation at pH 5.6 and pH 7.2 at 23 degrees C. The addition of ferrous iron significantly (p &lt; 0.05) increased the rate of myoglobin oxidation in the absence of lipid, demonstrating that iron promoted myoglobin oxidation independent of the effect of lipid oxidation.	Iron	145-149	myoglobin	Homo sapiens	200-209
17177551-1	2006	A model system was used to study the effect of nonheme iron on myoglobin oxidation at pH 5.6 and pH 7.2 at 23 degrees C. The addition of ferrous iron significantly (p &lt; 0.05) increased the rate of myoglobin oxidation in the absence of lipid, demonstrating that iron promoted myoglobin oxidation independent of the effect of lipid oxidation.	Iron	145-149	myoglobin	Homo sapiens	200-209
17177551-2	2006	The addition of the type II, iron chelating antioxidants sodium tripolyphosphate (at pH 7.2) or milk mineral (at pH 5.6) negated the effect of added iron, slowing oxidation of myoglobin.	Iron	29-33	myoglobin	Homo sapiens	176-185
17186687-4	2006	A trend between serum leptin and total iron binding capacity was observed, however, no correlation was observed with serum ferritin.	Iron	39-43	leptin	Homo sapiens	22-28
16842238-10	2006	We show that in vivo targeting of a human nucleoside diphosphate kinase (Nm23-H4), which converts ATP into GTP, to the matrix of ggc1 mutants restores normal iron regulation.	Iron	158-162	Ggc1p	Saccharomyces cerevisiae S288C	129-133
16842238-11	2006	Thus the role of Ggc1p in iron metabolism is mediated by effects on GTP/GDP levels in the mitochondrial matrix.	Iron	26-30	Ggc1p	Saccharomyces cerevisiae S288C	17-22
16959548-4	2006	Last, A-T cells exhibited increased short-term sensitivity to labile iron exposure compared to normal cells, an event corrected by recombinant ATM (rATM) expression.	Iron	69-73	ATM serine/threonine kinase	Homo sapiens	143-146
16959548-9	2006	ATM therefore functions in iron responses and the maintenance of genomic stability following labile iron exposure.	Iron	27-31	ATM serine/threonine kinase	Homo sapiens	0-3
16959548-9	2006	ATM therefore functions in iron responses and the maintenance of genomic stability following labile iron exposure.	Iron	100-104	ATM serine/threonine kinase	Homo sapiens	0-3
16950787-7	2006	Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and deferoxamine (an iron chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation was further investigated.	Iron	130-134	heme oxygenase 1	Homo sapiens	232-236
16804109-9	2006	These results suggest that anti-hTfR IgG3-Av induces lethal iron deprivation, but the resulting cell death does not solely depend on caspase activation.	Iron	60-64	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	37-41
16806171-3	2006	Ceruloplasmin, a protein with ferroxidase activity, and transferrin, an iron binding protein have important roles in maintaining iron homeostasis in cells.	Iron	129-133	ceruloplasmin	Homo sapiens	0-13
16806171-5	2006	In the current study of lens epithelial cells, the effects of ceruloplasmin and transferrin on intracellular distribution and efflux of iron were determined.	Iron	136-140	ceruloplasmin	Homo sapiens	62-75
16806171-6	2006	Both ceruloplasmin and transferrin increased iron efflux from these cells and their effects were additive.	Iron	45-49	ceruloplasmin	Homo sapiens	5-18
16806171-7	2006	Ceruloplasmin had significant effects on extracellular iron distribution only in cases of iron overload.	Iron	55-59	ceruloplasmin	Homo sapiens	0-13
16806171-7	2006	Ceruloplasmin had significant effects on extracellular iron distribution only in cases of iron overload.	Iron	90-94	ceruloplasmin	Homo sapiens	0-13
16806171-8	2006	Surprisingly, both transferrin and ceruloplasmin had significant effects on intracellular iron distribution.	Iron	90-94	ceruloplasmin	Homo sapiens	35-48
16806171-9	2006	Under physiological conditions, ceruloplasmin increased iron incorporation into the storage protein, ferritin.	Iron	56-60	ceruloplasmin	Homo sapiens	32-45
16806171-11	2006	Measurements of an intracellular chelatable iron pool indicated that both transferrin and ceruloplasmin increased the size of this pool at 24 h, but these increases had different downstream effects.	Iron	44-48	ceruloplasmin	Homo sapiens	90-103
16800860-3	2006	The aim of the study was to examine the impact of lactoferrin (LF), an iron-binding protein, on ragweed (Ambrosia artemisiifolia) pollen extract (RWE)-induced cellular oxidative stress levels in cultured bronchial epithelial cells and accumulation of inflammatory and mucin-producing cells in airways in a mouse model of allergic airway inflammation.	Iron	71-75	lactotransferrin	Mus musculus	50-61
17131908-1	2006	Lactoferrin (Lf), an iron-binding multifunctional glycoprotein, abundantly present in colostrum and milk of different species such as humans, bovines, and mice has been shown that bovine colostral Lf is transported into the CSF via plasma in newborn calves.	Iron	21-25	lactotransferrin	Bos taurus	0-11
17003411-13	2006	The specific localization of HFE and its interacting proteins, TfR1 and TfR2, at the basolateral membrane of RPE is relevant to the regulation of iron homeostasis in this cell.	Iron	146-150	transferrin receptor 2	Homo sapiens	72-76
16959797-1	2006	Heme oxygenase-1 (HO-1) degrades heme into biliverdin, iron and CO.	Iron	55-59	heme oxygenase 1	Homo sapiens	0-16
16959797-1	2006	Heme oxygenase-1 (HO-1) degrades heme into biliverdin, iron and CO.	Iron	55-59	heme oxygenase 1	Homo sapiens	18-22
16973432-0	2006	The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.	Iron	54-58	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
16973432-0	2006	The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.	Iron	54-58	BRCA1 interacting helicase 1	Homo sapiens	33-38
16973432-4	2006	Three absolutely conserved cysteine residues provide ligands for the Fe-S cluster, which is essential for the helicase activity of XPD.	Iron	69-73	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	131-134
16973432-6	2006	Clinically relevant mutations in patients with trichothiodystrophy (TTD) and Fanconi anemia disrupt the Fe-S clusters of XPD and FancJ and thereby abolish helicase activity.	Iron	104-108	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	121-124
16973432-6	2006	Clinically relevant mutations in patients with trichothiodystrophy (TTD) and Fanconi anemia disrupt the Fe-S clusters of XPD and FancJ and thereby abolish helicase activity.	Iron	104-108	BRCA1 interacting helicase 1	Homo sapiens	129-134
16904349-4	2006	The preincubation in iron-free medium resulted in a slight decrease (20%) of DMT1 mRNA level.	Iron	21-25	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-81
16721761-0	2006	Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity.	Iron	87-91	glutathione peroxidase 1	Mus musculus	0-24
16721761-9	2006	These results demonstrate that GPx1 contributes to the rapid clearance of H(2)O(2) by mouse astrocytes and that both GPx1 and a high concentration of glutathione are required to protect these cells from iron-dependent peroxide damage.	Iron	203-207	glutathione peroxidase 1	Mus musculus	31-35
16769722-0	2006	Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria.	Iron	35-39	Fe(2+) transporter	Saccharomyces cerevisiae S288C	7-12
16769722-0	2006	Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria.	Iron	44-48	Fe(2+) transporter	Saccharomyces cerevisiae S288C	7-12
16769722-1	2006	Yeast Mrs3p and Mrs4p are evolutionarily conserved mitochondrial carrier proteins that transport iron into mitochondria under some conditions.	Iron	97-101	Fe(2+) transporter	Saccharomyces cerevisiae S288C	16-21
16892088-4	2006	Mutations in the adenosine triphosphate-binding cassette protein ABCB7, identified in XLSA with ataxia (XLSA-A), disrupt the maturation of cytosolic (Fe-S) clusters, leading to mitochondrial Fe accumulation.	Iron	150-152	ATP binding cassette subfamily B member 7	Homo sapiens	65-70
16841247-8	2006	The amount of HFE-beta2m in the apical membrane inversely correlated with apical iron uptake rates.	Iron	81-85	beta-2-microglobulin	Homo sapiens	18-24
16841247-10	2006	These results sustain a model by which direct interaction between DMT1 and HFE-beta2m in the apical membrane of Caco-2 cells result in down-regulation of apical iron uptake activity.	Iron	161-165	beta-2-microglobulin	Homo sapiens	79-85
16714370-2	2006	A number of hypotheses have been advanced which implicate a second oxidant besides the iron-oxo species designated as compound I (Cpd 1).	Iron	87-91	cerebellar ataxia, infantile nonprogressive, autosomal recessive	Homo sapiens	130-135
16714370-9	2006	The nature of the iron-oxygen species is less certain but is more likely to be iron-oxo Cpd 1, given the energetics of these reactions.	Iron	18-22	cerebellar ataxia, infantile nonprogressive, autosomal recessive	Homo sapiens	88-93
16714370-9	2006	The nature of the iron-oxygen species is less certain but is more likely to be iron-oxo Cpd 1, given the energetics of these reactions.	Iron	79-83	cerebellar ataxia, infantile nonprogressive, autosomal recessive	Homo sapiens	88-93
16960437-0	2006	Cisplatin-induced expression of iron-retaining genes FIT2 and FIT3 in Saccharomyces cerevisiae.	Iron	32-36	Fit3p	Saccharomyces cerevisiae S288C	62-66
16960437-1	2006	cDNA microarray analysis indicated that mRNA levels of Fit2p and Fit3p, proteins involved in iron retention within the yeast cell wall, were markedly increased by treatment of Saccharomyces cerevisiae with cisplatin.	Iron	93-97	Fit3p	Saccharomyces cerevisiae S288C	65-70
16828117-13	2006	Prussian blue and electron microscopy have revealed numerous iron particles in the cytoplasm of hES.	Iron	61-65	ribosome binding protein 1	Homo sapiens	96-99
16962038-0	2006	[To prevent and cure the iron overloads, the hopes of hepcidin].	Iron	25-29	hepcidin antimicrobial peptide	Homo sapiens	54-62
17008846-7	2006	CONCLUSIONS: In conclusion, low leptin levels were observed in thalassemic patients, which may be due to a toxic effect of iron to adipocytes.	Iron	123-127	leptin	Homo sapiens	32-38
16815956-3	2006	YSL1 and YSL3 are similar to the maize (Zea mays) YS1 phytosiderophore transporter (ZmYS1) and the AtYSL2 iron (Fe)-nicotianamine transporter, and are predicted to transport metal-nicotianamine complexes into cells.	Iron	106-110	YELLOW STRIPE like 2	Arabidopsis thaliana	99-105
16790311-1	2006	Rhodanese or thiosulfate sulfurtransferase (TST) is a mitochondrial matrix enzyme that plays roles in cyanide detoxification, the formation of iron-sulfur proteins and the modification of sulfur-containing enzymes.	Iron	143-147	thiosulfate sulfurtransferase	Homo sapiens	13-42
16790311-1	2006	Rhodanese or thiosulfate sulfurtransferase (TST) is a mitochondrial matrix enzyme that plays roles in cyanide detoxification, the formation of iron-sulfur proteins and the modification of sulfur-containing enzymes.	Iron	143-147	thiosulfate sulfurtransferase	Homo sapiens	44-47
16928320-0	2006	[An iron regulator hepcidin is affected by EPO].	Iron	4-8	erythropoietin	Mus musculus	43-46
16790283-4	2006	Hepcidin acts by binding to and inducing the degradation of the cellular iron exporter, ferroportin, found in sites of major iron flows: duodenal enterocytes involved in iron absorption, macrophages that recycle iron from senescent erythrocytes, and hepatocytes that store iron.	Iron	125-129	hepcidin antimicrobial peptide	Homo sapiens	0-8
16790283-5	2006	Hepcidin synthesis is in turn controlled by iron concentrations, hypoxia, anemia and inflammatory cytokines.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	0-8
16787441-2	2006	Heme oxygenase consists of two structurally related isozymes, heme oxygenase-1 and and heme oxygenase-2, each of which cleaves heme to form biliverdin, iron and carbon monoxide.	Iron	152-156	heme oxygenase 1	Homo sapiens	62-78
16475160-0	2006	Role of soluble ceruloplasmin in iron uptake by midbrain and hippocampus neurons.	Iron	33-37	ceruloplasmin	Homo sapiens	16-29
16475160-1	2006	Ceruloplasmin (CP) is essential for brain iron homeostasis.	Iron	42-46	ceruloplasmin	Homo sapiens	0-13
16475160-1	2006	Ceruloplasmin (CP) is essential for brain iron homeostasis.	Iron	42-46	ceruloplasmin	Homo sapiens	15-17
16475160-3	2006	In this study, we investigated the effects of soluble CP on iron influx and efflux in primary neuronal culture from the midbrain (the substantia nigra and striatum) and the hippocampus.	Iron	60-64	ceruloplasmin	Homo sapiens	54-56
16475160-4	2006	Our data showed that low concentrations of CP (2, 4, 8 microg/ml) can promote iron influx into iron-deficient neurons, but not the neurons with normal iron status.	Iron	78-82	ceruloplasmin	Homo sapiens	43-45
16475160-4	2006	Our data showed that low concentrations of CP (2, 4, 8 microg/ml) can promote iron influx into iron-deficient neurons, but not the neurons with normal iron status.	Iron	95-99	ceruloplasmin	Homo sapiens	43-45
16475160-4	2006	Our data showed that low concentrations of CP (2, 4, 8 microg/ml) can promote iron influx into iron-deficient neurons, but not the neurons with normal iron status.	Iron	95-99	ceruloplasmin	Homo sapiens	43-45
16475160-7	2006	The changes in quenching (iron influx) and also dequenching (iron efflux) of intracellular fluorescence, induced by the addition of CP with iron, in the midbrain neurons were no different from those in the hippocampus neurons.	Iron	61-65	ceruloplasmin	Homo sapiens	132-134
16475160-7	2006	The changes in quenching (iron influx) and also dequenching (iron efflux) of intracellular fluorescence, induced by the addition of CP with iron, in the midbrain neurons were no different from those in the hippocampus neurons.	Iron	61-65	ceruloplasmin	Homo sapiens	132-134
16475160-8	2006	The data showed that soluble CP has a role in iron uptake by iron-deficient brain neurons under our experimental conditions.	Iron	46-50	ceruloplasmin	Homo sapiens	29-31
16800612-7	2006	For ferrous Cyt c, the instantaneous photodissociation of the methionine side chain from the heme iron is the dominant event, and its rebinding proceeds in two phases, with time constants of approximately 5 and approximately 16 ps.	Iron	98-102	cytochrome c, somatic	Equus caballus	12-17
16627556-3	2006	Surprisingly, genes involved in HH encode for proteins that all affect pathways centered around liver hepcidin synthesis and its interaction with ferroportin, an iron exporter in enterocytes and macrophages.	Iron	162-166	hepcidin antimicrobial peptide	Homo sapiens	102-110
16627556-5	2006	Cytokine-mediated increases in hepcidin appear to be an important causative factor in anemia of inflammation, which is characterized by sequestration of iron in the macrophage system.	Iron	153-157	hepcidin antimicrobial peptide	Homo sapiens	31-39
16755382-11	2006	Screening of genes involved in brain iron metabolism showed a significant association of some sequence variations of the ceruloplasmin gene with PD.	Iron	37-41	ceruloplasmin	Homo sapiens	121-134
16495208-1	2006	Heme is a strong inducer and substrate of the stress protein heme oxygenase-1 (HO-1), which produces carbon monoxide, iron, and bilirubin.	Iron	118-122	heme oxygenase 1	Homo sapiens	61-77
16495208-1	2006	Heme is a strong inducer and substrate of the stress protein heme oxygenase-1 (HO-1), which produces carbon monoxide, iron, and bilirubin.	Iron	118-122	heme oxygenase 1	Homo sapiens	79-83
16621770-1	2006	A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	37-45
16621770-2	2006	Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
16621770-2	2006	Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
16650837-0	2006	Cellular iron concentrations directly affect the expression levels of norepinephrine transporter in PC12 cells and rat brain tissue.	Iron	9-13	solute carrier family 6 member 2	Rattus norvegicus	70-96
16650837-9	2006	In contrast, NET proteins levels in thalamus and locus ceruleus were strongly affected by regional iron deficiency with high correlations with iron concentrations (r &gt; 0.94 and r &gt; 0.80 respectively).	Iron	99-103	solute carrier family 6 member 2	Rattus norvegicus	13-16
16700608-10	2006	The Pt(5)Fe(2)/SiO(2) sample was also more active than Pt/SiO(2) for PROX with a selectivity of approximately 92% at 50 degrees C. In this case, the deactivation with time on stream was substantially slower, indicating that the highly reducing environment under the PROX conditions helps maintain the properties of the active Pt-Fe bimetallic sites.	Iron	9-11	pyruvate dehydrogenase complex component X	Homo sapiens	69-73
16700608-10	2006	The Pt(5)Fe(2)/SiO(2) sample was also more active than Pt/SiO(2) for PROX with a selectivity of approximately 92% at 50 degrees C. In this case, the deactivation with time on stream was substantially slower, indicating that the highly reducing environment under the PROX conditions helps maintain the properties of the active Pt-Fe bimetallic sites.	Iron	9-11	pyruvate dehydrogenase complex component X	Homo sapiens	266-270
16681389-7	2006	In further support of this hypothesis, recombinant HDAC8 purified from E. coli contains 8-fold more iron than zinc before dialysis, and the HDAC8 activity in cell lysates is oxygen-sensitive.	Iron	100-104	histone deacetylase 8	Homo sapiens	51-56
16391018-1	2006	Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis.	Iron	118-122	hepcidin antimicrobial peptide	Homo sapiens	0-8
16391018-4	2006	Conversely, bacterial stimulation of macrophages triggered a TLR4-dependent reduction in the iron exporter ferroportin.	Iron	93-97	toll like receptor 4	Homo sapiens	61-65
16540354-6	2006	We thus detected the novel TFR2 missense mutation I449V (exon 10; nt 1345 A --&gt; G) in the proband"s wife and daughter, neither of whom had anemia or iron overload.	Iron	152-156	transferrin receptor 2	Homo sapiens	27-31
16639025-12	2006	Along with previous studies that have demonstrated elevated iron levels in AMD retinas, early onset drusen formation in a patient with retinal iron overload resulting from aceruloplasminemia, and retinal degeneration with some features of macular degeneration in the iron-overloaded retinas of ceruloplasmin/hephestin knockout mice, the present study suggests that altered iron homeostasis is associated with AMD.	Iron	143-147	ceruloplasmin	Homo sapiens	173-186
16639025-12	2006	Along with previous studies that have demonstrated elevated iron levels in AMD retinas, early onset drusen formation in a patient with retinal iron overload resulting from aceruloplasminemia, and retinal degeneration with some features of macular degeneration in the iron-overloaded retinas of ceruloplasmin/hephestin knockout mice, the present study suggests that altered iron homeostasis is associated with AMD.	Iron	143-147	ceruloplasmin	Homo sapiens	173-186
16639025-12	2006	Along with previous studies that have demonstrated elevated iron levels in AMD retinas, early onset drusen formation in a patient with retinal iron overload resulting from aceruloplasminemia, and retinal degeneration with some features of macular degeneration in the iron-overloaded retinas of ceruloplasmin/hephestin knockout mice, the present study suggests that altered iron homeostasis is associated with AMD.	Iron	143-147	ceruloplasmin	Homo sapiens	173-186
16604073-1	2006	Hepcidin is a key regulator of systemic iron homeostasis.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
16604073-2	2006	Hepcidin deficiency induces iron overload, whereas hepcidin excess induces anemia.	Iron	28-32	hepcidin antimicrobial peptide	Homo sapiens	0-8
16604073-3	2006	Mutations in the gene encoding hemojuvelin (HFE2, also known as HJV) cause severe iron overload and correlate with low hepcidin levels, suggesting that hemojuvelin positively regulates hepcidin expression.	Iron	82-86	hemojuvelin BMP co-receptor	Homo sapiens	31-42
16604073-3	2006	Mutations in the gene encoding hemojuvelin (HFE2, also known as HJV) cause severe iron overload and correlate with low hepcidin levels, suggesting that hemojuvelin positively regulates hepcidin expression.	Iron	82-86	hemojuvelin BMP co-receptor	Homo sapiens	44-48
16604073-3	2006	Mutations in the gene encoding hemojuvelin (HFE2, also known as HJV) cause severe iron overload and correlate with low hepcidin levels, suggesting that hemojuvelin positively regulates hepcidin expression.	Iron	82-86	hemojuvelin BMP co-receptor	Homo sapiens	64-67
16627878-1	2006	Hepcidin is a proposed mammalian host defense peptide that was identified on the basis of its antimicrobial activity, but it was later shown to be a crucial regulator of iron homeostasis and a mediator of the anemia of chronic inflammation.	Iron	170-174	hepcidin antimicrobial peptide	Homo sapiens	0-8
16627878-10	2006	The results support a role for hepcidin as a key regulator of mammalian iron metabolism and chronic inflammation, whose expression correlates with the degree of stainable iron in BA.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	31-39
16627878-10	2006	The results support a role for hepcidin as a key regulator of mammalian iron metabolism and chronic inflammation, whose expression correlates with the degree of stainable iron in BA.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	31-39
16640594-9	2006	The localization and substrate specificity of HvYS1 is different from those of ZmYS1, indicating that HvYS1 is a specific transporter for iron(III)-phytosiderophore involved in primary iron acquisition from soil in barley roots.	Iron	138-142	iron-phytosiderophore transporter yellow stripe 1	Zea mays	79-84
16755911-6	2006	As both iron deficiency and iron excess are associated with cellular dysfunction, so hepcidin or hepcidin-related therapeutics could find a place in the treatment of various diseases such as hemochromatosis and anemia of chronic disease.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	85-93
16755911-6	2006	As both iron deficiency and iron excess are associated with cellular dysfunction, so hepcidin or hepcidin-related therapeutics could find a place in the treatment of various diseases such as hemochromatosis and anemia of chronic disease.	Iron	8-12	hepcidin antimicrobial peptide	Homo sapiens	97-105
16154248-2	2006	IroN promotes uptake of enterobactin, salmochelins and 2,3-dihydroxybenzoylserine, FepA transports enterobactin and 2,3-dihydroxybenzoylserine, and Cir is a receptor for 2,3-dihydroxybenzoylserine.	Iron	0-4	circling	Mus musculus	148-151
16459059-3	2006	The pinnacle was the discovery and identification of hepcidin, a hepatic antimicrobial peptide that regulates absorption to maintain iron homeostasis.	Iron	133-137	hepcidin antimicrobial peptide	Homo sapiens	53-61
16459059-4	2006	While the intricacies of its expression and regulation by HFE, transferrin receptor 2 and hemojuvelin are still speculative, hepcidin responsiveness has correlated negatively with iron absorption in different models and disorders of iron metabolism.	Iron	180-184	hepcidin antimicrobial peptide	Homo sapiens	125-133
16459059-5	2006	Consequently, hepcidin expression is repressed to enhance iron absorption during stimulated erythropoiesis even in situations of elevated iron stores.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	14-22
16459059-5	2006	Consequently, hepcidin expression is repressed to enhance iron absorption during stimulated erythropoiesis even in situations of elevated iron stores.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	14-22
16630211-0	2006	Hepcidin: an important new regulator of iron homeostasis.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
16630211-1	2006	Summary Hepcidin is an important and recently discovered regulator of iron homeostasis.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	8-16
16630211-2	2006	There is strong evidence in support of an important role for hepcidin dysregulation in the pathogenesis of iron overload disorders, and possibly in the aetiology of the anaemia of chronic disease.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	61-69
16545694-1	2006	BACKGROUND: Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin.	Iron	139-143	heme oxygenase 1	Homo sapiens	95-111
16545694-1	2006	BACKGROUND: Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin.	Iron	139-143	heme oxygenase 1	Homo sapiens	113-117
16498394-6	2006	In vitro cultures of myelodysplastic hematopoietic progenitors showed that both HF and MtF were expressed at a very early stage of erythroid differentiation, and that MtF expression is specifically related to mitochondrial iron loading.	Iron	223-227	ferritin mitochondrial	Homo sapiens	167-170
22061879-8	2006	It is suggested that a chloride anion assisted dissociation of iron from myoglobin could be rate-determining for Zn-pp formation in meat products.	Iron	63-67	myoglobin	Homo sapiens	73-82
16601269-1	2006	The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO).	Iron	262-266	heme oxygenase 1	Homo sapiens	75-79
16272461-2	2006	We tested the hypothesis that the cellular response to asbestos includes the transport and sequestration of this iron through (1) generation of superoxide for ferrireduction, (2) up-regulation of divalent metal transporter-1 (DMT1) for intracellular transport of Fe2+, and (3) increased production of cellular ferritin where the metal is stored in a catalytically less reactive state.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	196-224
16272461-2	2006	We tested the hypothesis that the cellular response to asbestos includes the transport and sequestration of this iron through (1) generation of superoxide for ferrireduction, (2) up-regulation of divalent metal transporter-1 (DMT1) for intracellular transport of Fe2+, and (3) increased production of cellular ferritin where the metal is stored in a catalytically less reactive state.	Iron	113-117	solute carrier family 11 member 2	Homo sapiens	226-230
16474007-2	2006	Iron absorption across the brush-border membrane requires divalent metal transporter 1 (DMT1), whereas ferroportin (FPN) and hephaestin are required for exit across the basolateral membrane.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	58-86
16474007-2	2006	Iron absorption across the brush-border membrane requires divalent metal transporter 1 (DMT1), whereas ferroportin (FPN) and hephaestin are required for exit across the basolateral membrane.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	88-92
16474007-5	2006	With iron feeding, DMT1 undergoes endocytosis and FPN translocates from the apical cytosol to the basolateral membrane.	Iron	5-9	solute carrier family 11 member 2	Homo sapiens	19-23
16386335-10	2006	The synaptosomes isolated from gerbil pre-injected with FAEE and subsequently treated with AAPH or Fe(2+)/H(2)O(2) showed induction of heme oxygenase (HO-1) and heat shock protein 70 (HSP-70) but reduced inducible nitric oxide synthase (iNOS) levels.	Iron	99-101	heme oxygenase 1	Homo sapiens	151-155
16461380-1	2006	AtATM3, an ATP-binding cassette transporter of Arabidopsis (Arabidopsis thaliana), is a mitochondrial protein involved in the biogenesis of iron-sulfur clusters and iron homeostasis in plants.	Iron	140-144	ABC transporter of the mitochondrion 3	Arabidopsis thaliana	0-6
16487711-4	2006	The identification of HCP1 has revealed the long-sought mechanism by which haem--an important source of dietary iron--is absorbed from the diet by the gut.	Iron	112-116	solute carrier family 46 member 1	Homo sapiens	22-26
16477023-6	2006	These characteristics of the IDO structure provide support for a reaction mechanism involving the abstraction of a proton from the substrate by iron-bound dioxygen.	Iron	144-148	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
16387767-0	2006	The Fe-CO bond energy in myoglobin: a QM/MM study of the effect of tertiary structure.	Iron	4-6	myoglobin	Homo sapiens	25-34
16387767-1	2006	The Fe-CO bond dissociation energy (BDE) in myoglobin (Mb) has been calculated with B3LYP quantum mechanics/molecular mechanics methods for 22 different Mb conformations, generated from molecular dynamics simulations.	Iron	4-6	myoglobin	Homo sapiens	44-53
16137675-3	2006	Biodegradation of extravasated hemoglobin (exvHb) and deposition of iron in alveoli occurred at 3-56 h post-exposure and was preceded by LKC degranulation and accumulation of MPO, HO-1, and SOD-1 in HLs.	Iron	68-72	heme oxygenase 1	Homo sapiens	180-184
16436429-4	2006	Loss of RsmA altered the expression of genes involved in a variety of pathways and systems important for virulence, including iron acquisition, biosynthesis of the Pseudomonas quinolone signal (PQS), the formation of multidrug efflux pumps, and motility.	Iron	126-130	carbon storage regulator	Pseudomonas aeruginosa PAO1	8-12
16470637-4	2006	The observations that iron induces aggregation of inert alpha-synuclein and beta-amyloid peptides to toxic aggregates have reinforced the critical role of iron in OS-induced pathogenesis of neurodegeneration, supporting the notion that a combination of iron chelation and antioxidant therapy may be one significant approach for neuroprotection.	Iron	22-26	synuclein alpha	Homo sapiens	56-71
16420054-3	2006	Three important discoveries have been made, which will impact future IDO inhibitor development: (i) The dithiocarbamate portion of the brassinin lead is a crucial moiety, which may be binding to the heme iron of IDO; (ii) an indole ring is not necessary for IDO inhibition; and (iii) substitution of the S-methyl group of brassinin with large aromatic groups provides inhibitors that are three times more potent in vitro than the most commonly used IDO inhibitor, 1-methyl-tryptophan.	Iron	204-208	indoleamine 2,3-dioxygenase 1	Homo sapiens	69-72
16420054-3	2006	Three important discoveries have been made, which will impact future IDO inhibitor development: (i) The dithiocarbamate portion of the brassinin lead is a crucial moiety, which may be binding to the heme iron of IDO; (ii) an indole ring is not necessary for IDO inhibition; and (iii) substitution of the S-methyl group of brassinin with large aromatic groups provides inhibitors that are three times more potent in vitro than the most commonly used IDO inhibitor, 1-methyl-tryptophan.	Iron	204-208	indoleamine 2,3-dioxygenase 1	Homo sapiens	212-215
16420054-3	2006	Three important discoveries have been made, which will impact future IDO inhibitor development: (i) The dithiocarbamate portion of the brassinin lead is a crucial moiety, which may be binding to the heme iron of IDO; (ii) an indole ring is not necessary for IDO inhibition; and (iii) substitution of the S-methyl group of brassinin with large aromatic groups provides inhibitors that are three times more potent in vitro than the most commonly used IDO inhibitor, 1-methyl-tryptophan.	Iron	204-208	indoleamine 2,3-dioxygenase 1	Homo sapiens	212-215
16420054-3	2006	Three important discoveries have been made, which will impact future IDO inhibitor development: (i) The dithiocarbamate portion of the brassinin lead is a crucial moiety, which may be binding to the heme iron of IDO; (ii) an indole ring is not necessary for IDO inhibition; and (iii) substitution of the S-methyl group of brassinin with large aromatic groups provides inhibitors that are three times more potent in vitro than the most commonly used IDO inhibitor, 1-methyl-tryptophan.	Iron	204-208	indoleamine 2,3-dioxygenase 1	Homo sapiens	212-215
16424658-0	2006	Hemochromatosis and severe iron overload associated with compound heterozygosity for TFR2 R455Q and two novel mutations TFR2 R396X and G792R.	Iron	27-31	transferrin receptor 2	Homo sapiens	85-89
16424658-0	2006	Hemochromatosis and severe iron overload associated with compound heterozygosity for TFR2 R455Q and two novel mutations TFR2 R396X and G792R.	Iron	27-31	transferrin receptor 2	Homo sapiens	120-124
16424658-1	2006	We report three mutations of transferrin receptor 2 (TFR2)--R396X (exon 9; nt 1186C--&gt;T), R455Q (exon 10; nt 1364G--&gt;A) and G792R (exon 18; nt 2374G--&gt;A)--in a man of Scottish descent with hemochromatosis and severe iron overload.	Iron	225-229	transferrin receptor 2	Homo sapiens	29-51
16424658-1	2006	We report three mutations of transferrin receptor 2 (TFR2)--R396X (exon 9; nt 1186C--&gt;T), R455Q (exon 10; nt 1364G--&gt;A) and G792R (exon 18; nt 2374G--&gt;A)--in a man of Scottish descent with hemochromatosis and severe iron overload.	Iron	225-229	transferrin receptor 2	Homo sapiens	53-57
17117609-0	2006	Successful treatment of iron overload with phlebotomies in two siblings with congenital dyserythropoietic anemia--type II (CDA-II).	Iron	24-28	SEC23 homolog B, COPII coat complex component	Homo sapiens	77-121
17117609-0	2006	Successful treatment of iron overload with phlebotomies in two siblings with congenital dyserythropoietic anemia--type II (CDA-II).	Iron	24-28	SEC23 homolog B, COPII coat complex component	Homo sapiens	123-129
17117609-1	2006	Successful treatment of iron overload by phlebotomies has been reported in two splenectomized siblings with congenital dyserythropoietic anemia--type II (CDA-II).	Iron	24-28	SEC23 homolog B, COPII coat complex component	Homo sapiens	108-152
17117609-1	2006	Successful treatment of iron overload by phlebotomies has been reported in two splenectomized siblings with congenital dyserythropoietic anemia--type II (CDA-II).	Iron	24-28	SEC23 homolog B, COPII coat complex component	Homo sapiens	154-160
17119323-1	2006	INTRODUCTION: Prohepcidin is the precursor of hepcidin, a liver-derived peptide involved in iron metabolism by blocking its intestinal absorption and its release by the reticuloendothelial system.	Iron	92-96	hepcidin antimicrobial peptide	Homo sapiens	17-25
17119323-2	2006	Iron overload and inflammation increase hepcidin expression, whereas anemia and hypoxia suppress it.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	40-48
16433737-12	2006	CONCLUSION: The down-regulation of hepcidin and C/EBPalpha gene expression shown in vivo implies disturbed iron sensing contributing to the hepatosiderosis seen in alcoholic liver disease, possibly by mechanisms involving the IL-6 signaling cascade.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	35-43
16409153-3	2006	Hepcidin, with its cognate receptor, ferroportin, has emerged as a central regulator of iron homeostasis; all of the known causes of hemochromatosis appear to prevent this system from functioning normally.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	0-8
16125833-1	2006	Hepcidin is a liver-expressed antimicrobial and iron regulatory peptide.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	0-8
16125833-2	2006	A number of studies have indicated that hepcidin is important for the correct regulation of body iron homeostasis.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	40-48
16629181-7	2006	These results suggested that heme oxygenase-1 mediates heme iron influx and efflux in intestinal cells.	Iron	60-64	heme oxygenase 1	Homo sapiens	29-45
17087649-0	2006	Serum pro-hepcidin concentrations and their responses to oral iron supplementation in healthy subjects manifest considerable inter-individual variation.	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	10-18
17087649-1	2006	Hepcidin participates in the regulation of iron homeostasis and its precursor pro-hepcidin can be measured in serum.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	0-8
17087649-5	2006	The responses of serum pro-hepcidin to a 100-mg oral dose of iron also showed considerable inter-individual variation.	Iron	61-65	hepcidin antimicrobial peptide	Homo sapiens	27-35
17087649-7	2006	In nine out of the ten female subjects who had rather low amounts of storage iron, iron supplementation was followed by an increase in both serum iron and serum pro-hepcidin concentrations.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	165-173
17087649-7	2006	In nine out of the ten female subjects who had rather low amounts of storage iron, iron supplementation was followed by an increase in both serum iron and serum pro-hepcidin concentrations.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	165-173
17124036-0	2006	Hepcidin and its role in regulating systemic iron metabolism.	Iron	45-49	hepcidin antimicrobial peptide	Homo sapiens	0-8
17124036-3	2006	Hepcidin is a 25-amino acid disulfide-rich peptide synthesized in the liver that acts as a systemic iron-regulatory hormone by regulating iron transport from iron-exporting tissues into plasma.	Iron	100-104	hepcidin antimicrobial peptide	Homo sapiens	0-8
17124036-3	2006	Hepcidin is a 25-amino acid disulfide-rich peptide synthesized in the liver that acts as a systemic iron-regulatory hormone by regulating iron transport from iron-exporting tissues into plasma.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	0-8
17124036-4	2006	Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the degradation of, ferroportin, the sole iron exporter in iron-transporting cells.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
17124036-4	2006	Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the degradation of, ferroportin, the sole iron exporter in iron-transporting cells.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	0-8
17124036-4	2006	Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the degradation of, ferroportin, the sole iron exporter in iron-transporting cells.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	0-8
17124036-5	2006	In turn, hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	9-17
17124036-6	2006	Additionally, hepcidin synthesis is greatly increased during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations and causing iron-restricted erythropoiesis characteristic of anemia of inflammation (anemia of chronic disease).	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	14-22
17124036-6	2006	Additionally, hepcidin synthesis is greatly increased during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations and causing iron-restricted erythropoiesis characteristic of anemia of inflammation (anemia of chronic disease).	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	14-22
17124036-6	2006	Additionally, hepcidin synthesis is greatly increased during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations and causing iron-restricted erythropoiesis characteristic of anemia of inflammation (anemia of chronic disease).	Iron	123-127	hepcidin antimicrobial peptide	Homo sapiens	14-22
17124036-9	2006	The central involvement of hepcidin in iron regulation and its pathologies should make the eventual hepcidin assay useful for the diagnosis of iron disorders and the monitoring of their treatments.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	27-35
17124036-9	2006	The central involvement of hepcidin in iron regulation and its pathologies should make the eventual hepcidin assay useful for the diagnosis of iron disorders and the monitoring of their treatments.	Iron	39-43	hepcidin antimicrobial peptide	Homo sapiens	100-108
16226391-7	2006	The pathogenesis of ACD had been poorly understood, but recently it has been shown that increased Il-6 upregulates the hepatic production of hepcidin, which, by binding to its cellular receptor, ferroportin, causes anemia by blocking iron export from enterocytes and macrophages.	Iron	234-238	hepcidin antimicrobial peptide	Homo sapiens	141-149
16775387-1	2006	Aceruloplasminemia is a neurodegenerative disease characterized by parenchymal iron accumulation owing to mutations in the ceruloplasmin gene.	Iron	79-83	ceruloplasmin	Cricetulus griseus	1-14
16249327-1	2006	Three nuclear genes, SDH2-1, SDH2-2 and SDH2-3, encode the essential iron-sulfur subunit of mitochondrial complex II in Arabidopsis thaliana.	Iron	69-73	succinate dehydrogenase 2-3	Arabidopsis thaliana	40-46
16203112-1	2005	Hepcidin is a beta-defensin-like peptide and a principle regulator of systemic iron homeostasis.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	0-8
16203112-3	2005	Studies of hepcidin provide novel insight into the molecular mechanisms involved in maintaining iron homeostasis in the healthy state and iron redistribution in response to chronic infections and inflammation.	Iron	96-100	hepcidin antimicrobial peptide	Homo sapiens	11-19
16203112-3	2005	Studies of hepcidin provide novel insight into the molecular mechanisms involved in maintaining iron homeostasis in the healthy state and iron redistribution in response to chronic infections and inflammation.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	11-19
16203112-4	2005	Furthermore, a deregulation of hepcidin may cause elevated intestinal iron absorption that hallmarks a group of frequent iron overload disorders, the Hereditary Hemochromatosis.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	31-39
16203112-4	2005	Furthermore, a deregulation of hepcidin may cause elevated intestinal iron absorption that hallmarks a group of frequent iron overload disorders, the Hereditary Hemochromatosis.	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	31-39
16203112-5	2005	The aim of this review is to discuss hepcidin function in iron-homeostasis under normal physiological and pathophysiological conditions.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	37-45
16249174-0	2005	Sequences required for the activity of PTOX (IMMUTANS), a plastid terminal oxidase: in vitro and in planta mutagenesis of iron-binding sites and a conserved sequence that corresponds to Exon 8.	Iron	122-126	Alternative oxidase family protein	Arabidopsis thaliana	39-43
16195232-1	2005	We have recently shown that dinitrosyl diglutathionyl iron complex, a possible in vivo nitric oxide (NO) donor, binds with extraordinary affinity to one of the active sites of human glutathione transferase (GST) P1-1 and triggers negative cooperativity in the neighboring subunit of the dimer.	Iron	54-58	glutathione S-transferase pi 1	Homo sapiens	182-216
16195232-7	2005	Electron paramagnetic resonance spectroscopy studies on intact Escherichia coli cells expressing the recombinant GST P1-1 enzyme indicate that bacterial cells, in response to NO treatment, are able to form the dinitrosyl diglutathionyl iron complex using intracellular iron and GSH.	Iron	236-240	glutathione S-transferase pi 1	Homo sapiens	113-121
16030190-4	2005	Molecular studies have identified the systemic loop that controls iron homeostasis and is centered on the hepcidin-ferroportin interaction.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	106-114
16351644-1	2005	Ferroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin.	Iron	56-60	solute carrier family 40 member 1	Homo sapiens	30-37
16351644-1	2005	Ferroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	99-107
16351644-2	2005	SLC40A1 gene mutations are associated with an autosomal type of genetic iron overload described as haemochromatosis type 4, or HFE4 (Online Mendelian Inheritance in Man number 606069), or ferroportin disease.	Iron	72-76	solute carrier family 40 member 1	Homo sapiens	0-7
16351224-4	2005	The magnetic domain at the apex of an iron-coated tip was manipulated by applying an external magnetic field.	Iron	38-42	TOR signaling pathway regulator	Homo sapiens	50-53
16394640-3	2005	Recently, hepcidin, a peptide hormone secreted by hepatocytes in response to iron overload and inflammation, has been identified to be a predominant negative regulator of iron absorption in the duodenum and iron release from tissue macrophages.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	10-18
16394640-3	2005	Recently, hepcidin, a peptide hormone secreted by hepatocytes in response to iron overload and inflammation, has been identified to be a predominant negative regulator of iron absorption in the duodenum and iron release from tissue macrophages.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	10-18
16394640-3	2005	Recently, hepcidin, a peptide hormone secreted by hepatocytes in response to iron overload and inflammation, has been identified to be a predominant negative regulator of iron absorption in the duodenum and iron release from tissue macrophages.	Iron	171-175	hepcidin antimicrobial peptide	Homo sapiens	10-18
16394640-4	2005	The discovery of hepcidin unexpectedly revealed the link between iron metabolism and host defense.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	17-25
16307363-0	2005	Endosperm-specific co-expression of recombinant soybean ferritin and Aspergillus phytase in maize results in significant increases in the levels of bioavailable iron.	Iron	161-165	ferritin-1, chloroplastic	Glycine max	56-64
16307363-1	2005	We have generated transgenic maize plants expressing Aspergillus phytase either alone or in combination with the iron-binding protein ferritin.	Iron	113-117	ferritin-1, chloroplastic	Glycine max	134-142
16307363-5	2005	In seeds expressing ferritin in addition to phytase, the total iron content was significantly increased.	Iron	63-67	ferritin-1, chloroplastic	Glycine max	20-28
16307363-10	2005	We conclude that the expression of recombinant ferritin and phytase could help to increase iron availability and enhance the absorption of iron, particularly in cereal-based diets that lack other nutritional components.	Iron	91-95	ferritin-1, chloroplastic	Glycine max	47-55
16307363-10	2005	We conclude that the expression of recombinant ferritin and phytase could help to increase iron availability and enhance the absorption of iron, particularly in cereal-based diets that lack other nutritional components.	Iron	139-143	ferritin-1, chloroplastic	Glycine max	47-55
16125300-8	2005	The in silico docking of AAI to the active sites of CYP1A1 and 1A2 indicates that AAI binds as an axial ligand of the heme iron and that the nitro group of AAI is in close vicinity to the heme iron of CYP1A2 in an orientation allowing the efficient reduction of this group observed experimentally.	Iron	123-127	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	52-66
16125300-8	2005	The in silico docking of AAI to the active sites of CYP1A1 and 1A2 indicates that AAI binds as an axial ligand of the heme iron and that the nitro group of AAI is in close vicinity to the heme iron of CYP1A2 in an orientation allowing the efficient reduction of this group observed experimentally.	Iron	123-127	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	201-207
16125300-8	2005	The in silico docking of AAI to the active sites of CYP1A1 and 1A2 indicates that AAI binds as an axial ligand of the heme iron and that the nitro group of AAI is in close vicinity to the heme iron of CYP1A2 in an orientation allowing the efficient reduction of this group observed experimentally.	Iron	193-197	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	52-66
16125300-8	2005	The in silico docking of AAI to the active sites of CYP1A1 and 1A2 indicates that AAI binds as an axial ligand of the heme iron and that the nitro group of AAI is in close vicinity to the heme iron of CYP1A2 in an orientation allowing the efficient reduction of this group observed experimentally.	Iron	193-197	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	201-207
16125300-9	2005	The orientation of AAI in the active centre of CYP1A1 however causes an interaction of the heme iron with both the nitro- and the carboxylic groups of AAI.	Iron	96-100	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-53
16105697-7	2005	Relative to the two control groups, the low iron group weighed less on PN1, and this weight difference persisted in adulthood.	Iron	44-48	serpin family E member 2	Rattus norvegicus	71-74
16100038-7	2005	In addition, iron chelation attenuated Ang II-induced impairment of aortic relaxations in response to acetylcholine and sodium nitroprusside and suppressed upregulation of mRNA levels of monocyte chemoattractant protein-1.	Iron	13-17	C-C motif chemokine ligand 2	Rattus norvegicus	187-221
16000336-10	2005	The increase in pigment density is consistent with previously reported increases associated with oxidation and iron loading, reactions known to precipitate alpha-synuclein.	Iron	111-115	synuclein alpha	Homo sapiens	156-171
16269323-6	2005	Patients with autosomal recessive condition, aceruloplasminemia, lack the ferroxidase activity inherent to the multi-copper oxidase ceruloplasmin and develop abnormal iron accumulation within the central nervous system.	Iron	167-171	ceruloplasmin	Homo sapiens	46-59
16269323-7	2005	In the following review ceruloplasmin gene expression, structure and function will be presented and the role of ceruloplasmin in iron metabolism will be discussed.	Iron	129-133	ceruloplasmin	Homo sapiens	112-125
16271531-0	2005	Unexpected role of ceruloplasmin in intestinal iron absorption.	Iron	47-51	ceruloplasmin	Mus musculus	19-32
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	129-133	ceruloplasmin	Mus musculus	39-52
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	162-166	ceruloplasmin	Mus musculus	39-52
16271531-2	2005	The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.	Iron	162-166	ceruloplasmin	Mus musculus	39-52
16081413-8	2005	We show that the ATP7A protein is present on apical domains of duodenal enterocytes in control rats and on brush-border and basolateral membrane domains in iron-deprived rats.	Iron	156-160	ATPase copper transporting alpha	Rattus norvegicus	17-22
16267389-1	2005	Ceruloplasmin (Cp) is a copper protein with important functions in iron homeostasis and in inflammation.	Iron	67-71	ceruloplasmin	Homo sapiens	0-13
15998830-8	2005	In cells engineered to express hemojuvelin, soluble hemojuvelin release was progressively inhibited by increasing iron concentrations.	Iron	114-118	hemojuvelin BMP co-receptor	Homo sapiens	31-42
15998830-8	2005	In cells engineered to express hemojuvelin, soluble hemojuvelin release was progressively inhibited by increasing iron concentrations.	Iron	114-118	hemojuvelin BMP co-receptor	Homo sapiens	52-63
15998830-9	2005	We propose that soluble and cell-associated hemojuvelin reciprocally regulate hepcidin expression in response to changes in extracellular iron concentration.	Iron	138-142	hemojuvelin BMP co-receptor	Homo sapiens	44-55
15998830-9	2005	We propose that soluble and cell-associated hemojuvelin reciprocally regulate hepcidin expression in response to changes in extracellular iron concentration.	Iron	138-142	hepcidin antimicrobial peptide	Homo sapiens	78-86
16221434-0	2005	[The iron hormone hepcidin: A future diagnostic marker and therapeutic target in the treatment of anemia and hemochromatosis?	Iron	5-9	hepcidin antimicrobial peptide	Homo sapiens	18-26
16190762-8	2005	Experiments using ERalpha- and ERbeta-knockout mice demonstrated the expected ERalpha-subtype dependence in the tissue uptake of the known 16alpha-[18F]fluoro-17beta-estradiol ([18F]FES), which has a 6.3-fold preference for ERalpha.	Iron	182-185	estrogen receptor 1 (alpha)	Mus musculus	78-85
16190762-8	2005	Experiments using ERalpha- and ERbeta-knockout mice demonstrated the expected ERalpha-subtype dependence in the tissue uptake of the known 16alpha-[18F]fluoro-17beta-estradiol ([18F]FES), which has a 6.3-fold preference for ERalpha.	Iron	182-185	estrogen receptor 1 (alpha)	Mus musculus	78-85
16234038-4	2005	Heterozygosity for mutations in the gene encoding ferroportin 1 (FPN1) is probably the second most common genetic cause of hereditary iron storage in adults; here the primarily affected cell is the macrophage.	Iron	134-138	solute carrier family 40 member 1	Homo sapiens	50-63
16234038-4	2005	Heterozygosity for mutations in the gene encoding ferroportin 1 (FPN1) is probably the second most common genetic cause of hereditary iron storage in adults; here the primarily affected cell is the macrophage.	Iron	134-138	solute carrier family 40 member 1	Homo sapiens	65-69
16168234-3	2005	The subsequent movement of iron across the basolateral membrane and into the circulation is mediated by ferroportin1 in conjunction with the iron oxidase hephaestin.	Iron	27-31	solute carrier family 40 member 1	Homo sapiens	104-116
16257259-4	2005	Removal of hepatic excess iron by phlebotomy significantly decreased the serum levels of TRX and ALT in NASH patient.	Iron	26-30	thioredoxin	Homo sapiens	89-92
16164555-1	2005	In its mammalian host, Trypanosoma brucei covers its iron requirements by receptor-mediated uptake of host transferrin (Tf).	Iron	53-57	inhibitor of carbonic anhydrase	Canis lupus familiaris	107-118
16309585-2	2005	HO-1 catalyzes the conversion of heme into carbon monoxide (CO), iron, and biliverdin, which is subsequently converted to bilirubin.	Iron	65-69	heme oxygenase 1	Homo sapiens	0-4
15993492-4	2005	Disruption of iron levels in infected macrophages by addition of apotransferrin or bovine lactoferrin blocked replication of M. bovis in both bovine and possum macrophages.	Iron	14-18	lactotransferrin	Bos taurus	90-101
16106293-7	2005	Together the results reveal that for the "natural" C-2 stereochemistry of 2S-naringenin, C-3 hydroxylation predominates (&gt;9 : 1) over desaturation, probably due to the inaccessibility of the C-2 hydrogen to the iron centre.	Iron	214-218	complement C2	Homo sapiens	51-54
15901240-6	2005	TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P&lt;0.05).	Iron	45-49	solute carrier family 11 member 2	Homo sapiens	111-116
15901240-6	2005	TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P&lt;0.05).	Iron	45-49	solute carrier family 40 member 1	Homo sapiens	121-127
15901240-7	2005	However, by 24 h, both iron import and iron export were significantly inhibited, coinciding with an induction of ferritin heavy chain (P&lt;0.05) and a decrease in DMT-1 and IREG-1 to baseline levels.	Iron	23-27	ferritin heavy chain 1	Homo sapiens	113-133
15886319-1	2005	Hepatic peptide hormone hepcidin is the key regulator of iron metabolism and the mediator of anemia of inflammation.	Iron	57-61	hepcidin antimicrobial peptide	Homo sapiens	24-32
16023393-2	2005	A single patient with severe microcytic anemia and iron overload was recently reported to carry a mutation in exon 12 of DMT1 (1285G&gt;C).	Iron	51-55	solute carrier family 11 member 2	Homo sapiens	121-125
15869836-9	2005	Muscle iron increased in ethanol, low protein fed rats, either with or without zinc, and was directly related with muscle MDA levels, which in turn were related with muscle atrophy, as was also found for serum IGF-1 levels.	Iron	7-11	insulin-like growth factor 1	Rattus norvegicus	210-215
16117536-3	2005	The peroxo unit is bound end-on to the copper, and side-on to the high-spin iron, for an overall mu-eta(1):eta(2) coordination mode.	Iron	76-80	secreted phosphoprotein 1	Homo sapiens	100-106
16117536-8	2005	The pi*(sigma) interaction with both the half-occupied d(z)2 orbital on the copper (eta(1)) and the d(xz) orbital on the iron (eta(2)), provides an effective superexchange pathway for strong antiferromagnetic coupling between the metal centers.	Iron	121-125	secreted phosphoprotein 1	Homo sapiens	84-90
15972819-6	2005	Iron (II) decreases the binding of intact IGFBP-1 and the C-terminal domain to IGF-II, suggesting that the metal binding site is close to or part of the surface of interaction of the two molecules.	Iron	0-4	insulin like growth factor binding protein 1	Homo sapiens	42-49
15972819-6	2005	Iron (II) decreases the binding of intact IGFBP-1 and the C-terminal domain to IGF-II, suggesting that the metal binding site is close to or part of the surface of interaction of the two molecules.	Iron	0-4	insulin like growth factor 2	Homo sapiens	79-85
16110529-2	2005	Here we show that the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly.	Iron	155-157	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	103-117
16110529-2	2005	Here we show that the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly.	Iron	155-157	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	119-123
16110529-4	2005	Zebrafish grx5 rescued the assembly of grx5 yeast Fe-S, showing that the biochemical function of grx5 is evolutionarily conserved.	Iron	50-54	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	10-14
16110529-4	2005	Zebrafish grx5 rescued the assembly of grx5 yeast Fe-S, showing that the biochemical function of grx5 is evolutionarily conserved.	Iron	50-54	glutaredoxin 5 homolog (S. cerevisiae)	Danio rerio	39-43
16114530-1	2005	We investigated the beam-fanning effect in Fe-doped stoichiometric lithium niobate (Fe:SLN) crystals that were grown by the top-seeded solution growth method.	Iron	43-45	sarcolipin	Homo sapiens	87-90
16114530-5	2005	The results compared with those for Fe-doped congruent lithium niobate crystals indicate that the beam-fanning process in Fe:SLN is deterministic because of its much-reduced intrinsic density of defects.	Iron	36-38	sarcolipin	Homo sapiens	125-128
16124297-3	2005	In the present study, the abiotic dehalogenation of CCl4 by Fe(II) present at the surface of different iron minerals has been characterized in terms of the reaction rates and carbon isotopic fractionation (delta13C) of carbon tetrachloride (CCl4) as well as the yields and isotopic signatures of chloroform (CHCl3), one of the main transformation products.	Iron	103-107	C-C motif chemokine ligand 4	Homo sapiens	52-56
16124297-7	2005	Because this value matches well with the theoretical estimates for the cleavage of an aliphatic C-Cl bond, we suggest that dissociative electron transfer to CCl4 controls the reaction rates for this group of iron minerals.	Iron	208-212	C-C motif chemokine ligand 4	Homo sapiens	157-161
15930519-7	2005	Site-directed mutagenesis was used to support proposals for the identity of the iron binding ligands (His-175, Asp-177, His-264) of the 2-His-1-carboxylate motif of PAHX.	Iron	80-84	phytanoyl-CoA 2-hydroxylase	Homo sapiens	165-169
15950935-2	2005	Iron is believed to be a key contributor to PD pathology by inducing aggregation of alpha-synuclein and by generating oxidative stress.	Iron	0-4	synuclein, alpha	Mus musculus	84-99
15897206-9	2005	At 15 microm Fe, ferritin-like crystals were formed in the lumen of chloroplasts of "PI227557" plants.	Iron	13-15	ferritin-1, chloroplastic	Glycine max	17-25
15784734-6	2005	Feeding an iron-deficient diet for 2 months induced plasma erythropoietin elevation without obvious anemia, but the simultaneous repeated administration of estradiol suppressed it and reversed the iron deficiency.	Iron	11-15	erythropoietin	Rattus norvegicus	59-73
15784734-7	2005	Plasma erythropoietin levels had distinct negative correlations with plasma iron, plasma ferritin, and iron concentrations in the organs, but not with plasma hemoglobin level.	Iron	76-80	erythropoietin	Rattus norvegicus	7-21
15784734-7	2005	Plasma erythropoietin levels had distinct negative correlations with plasma iron, plasma ferritin, and iron concentrations in the organs, but not with plasma hemoglobin level.	Iron	103-107	erythropoietin	Rattus norvegicus	7-21
15784734-8	2005	These results suggest that iron deficiency would significantly stimulate erythropoietin induction during pregnancy, although estradiol might suppress it through iron restoration.	Iron	27-31	erythropoietin	Rattus norvegicus	73-87
15912551-6	2005	Comparison of the natures of the CD spectra in the 400 nm and 695 nm regions of the C357M mutant of cytochrome P450cam with those of horse cytochrome c suggested (R) chirality at the sulfur atom of the iron-bound methionine residue in the mutant.	Iron	202-206	cytochrome c, somatic	Equus caballus	139-151
15896335-3	2005	The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1.	Iron	4-8	solute carrier family 11 member 2	Homo sapiens	21-49
15896335-3	2005	The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1.	Iron	4-8	solute carrier family 11 member 2	Homo sapiens	51-56
15896335-3	2005	The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1.	Iron	4-8	solute carrier family 40 member 1	Homo sapiens	202-215
15896335-3	2005	The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	21-49
15896335-3	2005	The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1.	Iron	92-96	solute carrier family 11 member 2	Homo sapiens	51-56
15896335-3	2005	The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1.	Iron	92-96	solute carrier family 40 member 1	Homo sapiens	202-215
15896335-4	2005	A therapeutic approach for HH could start with a long-term reduction of iron transport by reduction of DMT-1 levels.	Iron	72-76	solute carrier family 11 member 2	Homo sapiens	103-108
15896335-5	2005	We designed an AAV vector coding for a short antisense RNA (AAV-DMT-1-AS) against DMT-1, which reduced iron uptake by 50-60% in human intestinal cells (Caco-2).	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	64-69
15896335-5	2005	We designed an AAV vector coding for a short antisense RNA (AAV-DMT-1-AS) against DMT-1, which reduced iron uptake by 50-60% in human intestinal cells (Caco-2).	Iron	103-107	solute carrier family 11 member 2	Homo sapiens	82-87
15896335-7	2005	DMT-1 mRNA levels returned to normal at higher infection levels, indicating that an additional mechanism of mRNA occupation, able to block DMT-1 translation and to avoid feedback regulation by iron responsive elements (IRE), also exists.	Iron	193-197	solute carrier family 11 member 2	Homo sapiens	0-5
15962935-0	2005	Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin: a mechanism to protect against oxidative stress without iron chelation.	Iron	145-149	myoglobin	Homo sapiens	78-87
15974953-0	2005	Hepcidin in iron metabolism.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	0-8
15974953-2	2005	Besides its potential activity in antimicrobial defense, hepcidin plays a major role in iron metabolism.	Iron	88-92	hepcidin antimicrobial peptide	Homo sapiens	57-65
15974953-4	2005	In humans, this could explain that low levels of hepcidin found during juvenile haemochromatosis and HFE-1 genetic haemochromatosis are associated with an iron overload phenotype.	Iron	155-159	hepcidin antimicrobial peptide	Homo sapiens	49-57
15974953-6	2005	However, the regulatory mechanisms of hepcidin expression are multiple, including iron-related parameters, anemia, hypoxia, inflammation and hepatocyte function.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	38-46
15905437-0	2005	Developmental gene expression of lactoferrin and effect of dietary iron on gene regulation of lactoferrin in mouse mammary gland.	Iron	67-71	lactotransferrin	Mus musculus	94-105
15905437-1	2005	This study evaluated the developmental gene expression of lactoferrin (LF) and the effect of supplementary iron on gene expression of LF in the mammary gland of mice using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis.	Iron	107-111	lactotransferrin	Mus musculus	134-136
15905437-5	2005	The experimental feeding period lasted 35 d. During the feeding experiment, 6 mice (3 animals in each group) were chosen on d 1, 9, 17, and 25 of lactation to determine the effect of iron on LF mRNA expression of mice at different stages of lactation.	Iron	183-187	lactotransferrin	Mus musculus	191-193
15905437-8	2005	Iron significantly increased LF mRNA expression on d 1 and 25 of lactation.	Iron	0-4	lactotransferrin	Mus musculus	29-31
15905437-10	2005	These findings raised the possibility that iron supplementation may play a role in regulation of LF levels in vivo.	Iron	43-47	lactotransferrin	Mus musculus	97-99
15845371-5	2005	After 57 weeks on this diet, hepatic preneoplastic foci and tumors were seen in the Cyp1a2(+/+) mice; numbers and severity were enhanced by iron.	Iron	140-144	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	84-90
16012127-1	2005	Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family.	Iron	18-22	lactotransferrin	Mus musculus	0-11
15705575-0	2005	Calorimetric studies of melanotransferrin (p97) and its interaction with iron.	Iron	73-77	melanotransferrin	Homo sapiens	24-41
15705575-0	2005	Calorimetric studies of melanotransferrin (p97) and its interaction with iron.	Iron	73-77	melanotransferrin	Homo sapiens	43-46
15836704-0	2005	Upregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C. BACKGROUND: Iron accumulation has been reported to be associated with progression of liver injury.	Iron	125-129	transferrin receptor 2	Homo sapiens	16-38
15836704-0	2005	Upregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C. BACKGROUND: Iron accumulation has been reported to be associated with progression of liver injury.	Iron	125-129	solute carrier family 40 member 1	Homo sapiens	43-56
15836704-12	2005	CONCLUSIONS: Hepatic iron accumulation is more severe in patients with CH-C.	Iron	21-25	clathrin heavy chain	Homo sapiens	71-75
15836704-13	2005	Upregulation of hepatic iron transporters may contribute to the hepatic iron accumulation in CH-C.	Iron	24-28	clathrin heavy chain	Homo sapiens	93-97
15755449-0	2005	Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin.	Iron	7-11	ferritin mitochondrial	Homo sapiens	54-76
15755449-5	2005	Parallel experiments with MtF and HuHF reported here reveal striking differences in their iron oxidation and hydrolysis chemistry despite their similar diFe ferroxidase centers.	Iron	90-94	ferritin mitochondrial	Homo sapiens	26-29
15755449-11	2005	Also, as for HuHF, minimal hydroxyl radical is produced during the oxidative deposition of iron in MtF using O(2) as the oxidant.	Iron	91-95	ferritin mitochondrial	Homo sapiens	99-102
15755449-13	2005	The structural differences and the physiological implications of the unique iron oxidation properties of MtF are discussed in light of these results.	Iron	76-80	ferritin mitochondrial	Homo sapiens	105-108
15752137-1	2005	Iron microbeads coated with the protein ligands insulin and EGF (Fe-INS and Fe-EGF) were prepared.	Iron	0-4	epidermal growth factor	Homo sapiens	60-63
15752137-1	2005	Iron microbeads coated with the protein ligands insulin and EGF (Fe-INS and Fe-EGF) were prepared.	Iron	0-4	epidermal growth factor	Homo sapiens	76-82
15546886-2	2005	This 21-amino acid peptide has 8 cysteines engaged in 4 disulfide bonds and is very similar to human hepcidin, an antimicrobial peptide with iron regulatory properties.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	101-109
15716025-3	2005	However, human MTf has only a single, high affinity, Fe-binding site.	Iron	53-55	melanotransferrin	Homo sapiens	15-18
15716025-4	2005	Furthermore, while isolated MTf can bind Fe, it plays little role in Fe uptake by cells and its function remains elusive.	Iron	41-43	melanotransferrin	Homo sapiens	28-31
15760883-2	2005	The lack of ceruloplasmin ferroxidase activity leads to parenchymal and reticuloendothelial iron overload, resulting in diabetes and progressive neurodegeneration with extrapyramidal disorders, ataxia, and dementia.	Iron	92-96	ceruloplasmin	Homo sapiens	12-37
15706088-0	2005	Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels.	Iron	114-118	heat shock protein family B (small) member 1	Homo sapiens	0-5
15843899-8	2005	Taken together, we suggest that iron deprivation induces apoptosis via mitochondrial changes concerning proapoptotic Bax translocation to mitochondria, collapse of the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and caspase-3.	Iron	32-36	caspase 9	Homo sapiens	263-272
15603911-6	2005	The current research challenges include understanding the central role of the HAMP gene (hepcidin) in controlling iron absorption and the reasons for the variable penetrance in HFE type 1.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	78-82
15603911-6	2005	The current research challenges include understanding the central role of the HAMP gene (hepcidin) in controlling iron absorption and the reasons for the variable penetrance in HFE type 1.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	89-97
15725899-2	2005	Recently hepcidin antimicrobial peptide has emerged as the hormone that links the type II acute phase response to iron handling and erythropoiesis.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	9-17
15725899-3	2005	RECENT FINDINGS: Hepcidin antimicrobial peptide likely modulates iron transport from macrophages and enterocytes to red blood cell precursors as a consequence of its interaction with SLC40A1/ferroportin, the only known transporter that facilitates iron egress.	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	17-25
15725899-3	2005	RECENT FINDINGS: Hepcidin antimicrobial peptide likely modulates iron transport from macrophages and enterocytes to red blood cell precursors as a consequence of its interaction with SLC40A1/ferroportin, the only known transporter that facilitates iron egress.	Iron	65-69	solute carrier family 40 member 1	Homo sapiens	183-190
15725899-3	2005	RECENT FINDINGS: Hepcidin antimicrobial peptide likely modulates iron transport from macrophages and enterocytes to red blood cell precursors as a consequence of its interaction with SLC40A1/ferroportin, the only known transporter that facilitates iron egress.	Iron	248-252	hepcidin antimicrobial peptide	Homo sapiens	17-25
15725899-3	2005	RECENT FINDINGS: Hepcidin antimicrobial peptide likely modulates iron transport from macrophages and enterocytes to red blood cell precursors as a consequence of its interaction with SLC40A1/ferroportin, the only known transporter that facilitates iron egress.	Iron	248-252	solute carrier family 40 member 1	Homo sapiens	183-190
15725899-4	2005	Insights into the regulation of hepcidin antimicrobial peptide expression by known iron metabolic proteins such as HFE, hemojuvelin, and transferrin receptor 2 are expanding the understanding of the genetic circuitry that controls iron absorption and utilization.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	32-40
15725899-4	2005	Insights into the regulation of hepcidin antimicrobial peptide expression by known iron metabolic proteins such as HFE, hemojuvelin, and transferrin receptor 2 are expanding the understanding of the genetic circuitry that controls iron absorption and utilization.	Iron	231-235	hepcidin antimicrobial peptide	Homo sapiens	32-40
15725899-6	2005	It receives multiple signals related to iron balance and responds via transcriptional control of hepcidin antimicrobial peptide.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	97-105
15309428-9	2005	Dietary fiber and vitamin A were positively related to IGF-I (p = 0.004 and 0.03), zinc with IGFB-3 (p = 0.0008), and iron with the IGF-I/IGFBP-3 ratio (p = 0.048), but the differences between the bottom and top quartile were less than 10%.	Iron	118-122	insulin like growth factor binding protein 3	Homo sapiens	138-145
15601666-1	2005	Solute carrier family 11a member 1 (Slc11a1; formerly natural resistance-associated macrophage protein 1) encodes a late endosomal/lysosomal protein/divalent cation transporter, which regulates iron homeostasis in macrophages.	Iron	194-198	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	36-43
15743333-0	2005	CSF iron, ferritin and transferrin levels in restless legs syndrome.	Iron	4-8	colony stimulating factor 2	Homo sapiens	0-3
15743333-6	2005	With CSF examination, the iron and ferritin values were lower and the transferrin values were higher in the RLS group than those in the non-RLS group.	Iron	26-30	colony stimulating factor 2	Homo sapiens	5-8
15649645-1	2005	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon monoxide (CO).	Iron	177-181	heme oxygenase 1	Homo sapiens	0-16
15649645-1	2005	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon monoxide (CO).	Iron	177-181	heme oxygenase 1	Homo sapiens	18-22
15649645-1	2005	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon monoxide (CO).	Iron	183-185	heme oxygenase 1	Homo sapiens	0-16
15649645-1	2005	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon monoxide (CO).	Iron	183-185	heme oxygenase 1	Homo sapiens	18-22
15686373-1	2005	The mammalian iron transporter, divalent metal transporter (DMT1), is a 12-transmembrane domain integral protein, responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	14-18	solute carrier family 11 member 2	Homo sapiens	60-64
15686373-1	2005	The mammalian iron transporter, divalent metal transporter (DMT1), is a 12-transmembrane domain integral protein, responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues.	Iron	138-142	solute carrier family 11 member 2	Homo sapiens	60-64
15664939-1	2005	The role of the Escherichia coli iron-regulated gene homologue adhesin (Iha) in the pathogenesis of urinary tract infections (UTIs) is unknown.	Iron	33-37	bifunctional enterobactin receptor/adhesin protein	Escherichia coli	72-75
15802016-1	2005	The heavy chain of murine ferritin, an iron storage molecule with ferroxidase activity, was developed as a novel endogenous reporter for the detection of gene expression by magnetic resonance imaging (MRI).	Iron	39-43	ceruloplasmin	Mus musculus	66-77
15546873-2	2005	Heme oxygenase-1 (HO-1) is a cytoprotective protein that catalyzes the degradation of heme to biliverdin, iron, and carbon monoxide (CO).	Iron	106-110	heme oxygenase 1	Homo sapiens	0-16
15546873-2	2005	Heme oxygenase-1 (HO-1) is a cytoprotective protein that catalyzes the degradation of heme to biliverdin, iron, and carbon monoxide (CO).	Iron	106-110	heme oxygenase 1	Homo sapiens	18-22
15652485-4	2005	We demonstrate that, in response to Fe deficiency, the Saccharomyces cerevisiae Cth2 protein specifically downregulates mRNAs encoding proteins that participate in many Fe-dependent processes.	Iron	36-38	Tis11p	Saccharomyces cerevisiae S288C	80-84
15631519-3	2005	Iron-loaded Caco-2 cells, with reduced DMT-1 and elevated HFE mRNA levels, down-regulated uptake from ferrous ascorbate and bisglycinate but not from ferric compounds.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	39-44
15531579-3	2005	Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT1).	Iron	246-250	serine hydroxymethyltransferase 1	Homo sapiens	322-365
15531579-3	2005	Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT1).	Iron	246-250	serine hydroxymethyltransferase 1	Homo sapiens	372-377
16339656-9	2005	Remarkably, binding of AHSP to oxygenated alphaHb induces dramatic conformational changes and converts the heme-bound iron to an oxidized hemichrome state in which all six coordinate positions are occupied.	Iron	118-122	alpha hemoglobin stabilizing protein	Mus musculus	23-27
16339656-10	2005	This structure limits the reactivity of heme iron, providing a mechanism by which AHSP stabilizes alphaHb.	Iron	45-49	alpha hemoglobin stabilizing protein	Mus musculus	82-86
16339657-3	2005	Another source of iron accumulation results from increased absorption due to decreased expression of hepcidin.	Iron	18-22	hepcidin antimicrobial peptide	Homo sapiens	101-109
16339657-10	2005	A possible way to decrease iron absorption could be by modulating hepcidin expression pharmacologically, by gene therapy or by its administration.	Iron	27-31	hepcidin antimicrobial peptide	Homo sapiens	66-74
16339659-0	2005	Ferritin as an iron concentrator and chelator target.	Iron	15-19	ferritin-1, chloroplastic	Glycine max	0-8
16339659-2	2005	Serum ferritin iron content is relegated to reporting on tissue iron concentrations.	Iron	15-19	ferritin-1, chloroplastic	Glycine max	6-14
16339659-3	2005	Recently, a new property of ferritin was discovered: gated pores, which are highly conserved in ferritins of humans down to bacteria, and control iron flow to chelators.	Iron	146-150	ferritin-1, chloroplastic	Glycine max	28-36
16339659-5	2005	In another recent observation, the iron in ferritin from seeds such as soybeans has been shown to be readily available to tissues with high demand for iron, such as red blood cells, but slower to be mobilized in other tissues, compared to nonheme iron salts, presumably through a controlled iron gating mechanism.	Iron	35-39	ferritin-1, chloroplastic	Glycine max	43-51
16339659-5	2005	In another recent observation, the iron in ferritin from seeds such as soybeans has been shown to be readily available to tissues with high demand for iron, such as red blood cells, but slower to be mobilized in other tissues, compared to nonheme iron salts, presumably through a controlled iron gating mechanism.	Iron	151-155	ferritin-1, chloroplastic	Glycine max	43-51
16076647-6	2005	A model for the pathway of induction of heme and iron homeostasis-related transcripts resulting from light pulses suggests that light signals (as stressors) induce transcription of heme oxygenase 2 (Hmox2) and cytochrome P450 oxidoreductase (Por), which may serve as a primary line of cellular defense.	Iron	49-53	heme oxygenase 2	Mus musculus	181-197
16076647-6	2005	A model for the pathway of induction of heme and iron homeostasis-related transcripts resulting from light pulses suggests that light signals (as stressors) induce transcription of heme oxygenase 2 (Hmox2) and cytochrome P450 oxidoreductase (Por), which may serve as a primary line of cellular defense.	Iron	49-53	heme oxygenase 2	Mus musculus	199-204
16076647-6	2005	A model for the pathway of induction of heme and iron homeostasis-related transcripts resulting from light pulses suggests that light signals (as stressors) induce transcription of heme oxygenase 2 (Hmox2) and cytochrome P450 oxidoreductase (Por), which may serve as a primary line of cellular defense.	Iron	49-53	cytochrome p450 oxidoreductase	Mus musculus	242-245
16305465-3	2005	We review our current understanding of the intestinal absorption of iron in the light of recently identified membrane proteins, namely the ferrric reductase, Dcytb, the two iron(II) transport proteins, DMT1 and ferroportin/Ireg1, and hephaestin, the membrane-bound homologue of the ferroxidase ceruloplasmin.	Iron	68-72	solute carrier family 40 member 1	Homo sapiens	223-228
16240664-3	2005	Iron absorption is regulated by divalent metal ion transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	32-64
16240664-3	2005	Iron absorption is regulated by divalent metal ion transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	66-70
16240664-3	2005	Iron absorption is regulated by divalent metal ion transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	76-89
16240664-3	2005	Iron absorption is regulated by divalent metal ion transporter 1 (DMT1) and ferroportin 1 (FPN1).	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	91-95
15750726-2	2005	One of those loci, FRR1 , was previously found homologous to MRS3 and MRS4 of Saccharomyces cerevisiae , which determine proteins involved in mitochondrial transport of iron.	Iron	169-173	Fe(2+) transporter	Saccharomyces cerevisiae S288C	70-74
15319276-1	2004	Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis.	Iron	55-59	transferrin receptor 2	Homo sapiens	0-22
15319276-1	2004	Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis.	Iron	55-59	transferrin receptor 2	Homo sapiens	24-28
15319290-1	2004	Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf).	Iron	100-104	transferrin receptor 2	Homo sapiens	0-22
15319290-1	2004	Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf).	Iron	100-104	transferrin receptor 2	Homo sapiens	24-28
15319290-2	2004	Mutations in TfR2 cause one form of hereditary hemochromatosis, a disease in which excessive absorption of dietary iron can lead to liver cirrhosis, diabetes, arthritis, and heart failure.	Iron	115-119	transferrin receptor 2	Homo sapiens	13-17
15319290-3	2004	The function of TfR2 in iron homeostasis is unknown.	Iron	24-28	transferrin receptor 2	Homo sapiens	16-20
15319290-11	2004	Our results support a role for TfR2 in monitoring iron levels by sensing changes in the concentration of diferric Tf.	Iron	50-54	transferrin receptor 2	Homo sapiens	31-35
15566364-8	2004	Second, this observation supports the hypothesis that reticuloendothelial iron overload in patients with ferroportin disease is caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling.	Iron	74-78	solute carrier family 40 member 1	Homo sapiens	172-179
15566364-8	2004	Second, this observation supports the hypothesis that reticuloendothelial iron overload in patients with ferroportin disease is caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling.	Iron	215-219	solute carrier family 40 member 1	Homo sapiens	172-179
15563524-3	2004	We show that cia encodes tfr1a, which is specifically expressed in the developing blood and requisite only for iron uptake in erythroid precursors.	Iron	111-115	transferrin receptor 1a	Danio rerio	25-30
15563524-6	2004	tfr1b morphants exhibited growth retardation and brain necrosis, similar to the central nervous system defects observed in the Tfr1 null mouse, indicating that tfr1b is probably used by non-erythroid tissues for iron acquisition.	Iron	212-216	transferrin receptor 1b	Danio rerio	0-5
15563524-6	2004	tfr1b morphants exhibited growth retardation and brain necrosis, similar to the central nervous system defects observed in the Tfr1 null mouse, indicating that tfr1b is probably used by non-erythroid tissues for iron acquisition.	Iron	212-216	transferrin receptor 1b	Danio rerio	160-165
15563524-7	2004	Overexpression of mouse Tfr1, mouse Tfr2, and zebrafish tfr1b partially rescued hypochromia in cia embryos, establishing that each of these transferrin receptors are capable of supporting iron uptake for hemoglobin production in vivo.	Iron	188-192	transferrin receptor 1b	Danio rerio	56-61
15557511-4	2004	One of these is ceruloplasmin (Cp), which is vitally involved in iron transport across the cell membrane.	Iron	65-69	ceruloplasmin	Homo sapiens	16-29
15557511-4	2004	One of these is ceruloplasmin (Cp), which is vitally involved in iron transport across the cell membrane.	Iron	65-69	ceruloplasmin	Homo sapiens	31-33
15557511-5	2004	METHODS: One hundred seventy-six patients with PD according to the UK Brain Bank criteria and 180 ethnically matched control subjects, who were previously examined for SN iron signal changes by transcranial ultrasound, were examined for mutations in the Cp gene using denaturing high-performance liquid chromatography and subsequent sequencing for verification of unequivocal signals.	Iron	171-175	ceruloplasmin	Homo sapiens	254-256
15389827-1	2004	Heme oxygenase type 2 (HO-2) is an enzyme that uses heme as a substrate to produce iron, biliverdin, and carbon monoxide (CO).	Iron	83-87	heme oxygenase 2	Mus musculus	0-21
15389827-1	2004	Heme oxygenase type 2 (HO-2) is an enzyme that uses heme as a substrate to produce iron, biliverdin, and carbon monoxide (CO).	Iron	83-87	heme oxygenase 2	Mus musculus	23-27
15844231-2	2004	Over the last decade, several new globins have been reported to display a functionally-relevant hexa-coordinate heme iron atom, whose sixth coordination site is taken by an endogenous protein ligand.	Iron	117-121	hexosaminidase subunit alpha	Homo sapiens	96-100
15844231-3	2004	The reversible intramolecular hexa- to penta-coordination process at the heme-Fe atom modulates exogenous ligand binding properties of hexa-coordinate globins.	Iron	78-80	hexosaminidase subunit alpha	Homo sapiens	30-34
15844231-3	2004	The reversible intramolecular hexa- to penta-coordination process at the heme-Fe atom modulates exogenous ligand binding properties of hexa-coordinate globins.	Iron	78-80	hexosaminidase subunit alpha	Homo sapiens	135-139
19667680-3	2004	After a brief review of iron homeostasis and a look at ACD in a historical context, she explores the significance of hepcidin, a recently discovered hormone involved in iron metabolism, and discusses a new hypothesis that connects hepcidin to the pathogenesis of ACD.	Iron	169-173	hepcidin antimicrobial peptide	Homo sapiens	117-125
15341964-2	2004	As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by &gt;8 logarithmic decades.	Iron	67-69	MS2	Homo sapiens	126-129
15203103-5	2004	The characterization of recombinant and transfected mitochondrial ferritin indicated that this protein has a role in protecting mitochondria from iron-induced damage.	Iron	146-150	ferritin mitochondrial	Homo sapiens	52-74
15382923-1	2004	The carbon monoxide (CO) docking sites involved in the ligand escape process from the iron atom in hem of myoglobin (Mb) to solution at physiological temperature were studied on the basis of the effect of xenon (Xe) on the ligand escape rate by the transient grating (TG) technique.	Iron	86-90	myoglobin	Homo sapiens	106-115
15358563-2	2004	Here, we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 (TfR1) mRNA level in placenta, as shown by cDNA microarray analysis and quantitative RT-PCR, by a mechanism which is independent of placenta iron content and iron responsive element/iron regulatory protein (IRE/IRP) activity.	Iron	235-239	hepcidin antimicrobial peptide	Homo sapiens	31-39
15358563-2	2004	Here, we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 (TfR1) mRNA level in placenta, as shown by cDNA microarray analysis and quantitative RT-PCR, by a mechanism which is independent of placenta iron content and iron responsive element/iron regulatory protein (IRE/IRP) activity.	Iron	252-256	hepcidin antimicrobial peptide	Homo sapiens	31-39
15358563-2	2004	Here, we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 (TfR1) mRNA level in placenta, as shown by cDNA microarray analysis and quantitative RT-PCR, by a mechanism which is independent of placenta iron content and iron responsive element/iron regulatory protein (IRE/IRP) activity.	Iron	252-256	hepcidin antimicrobial peptide	Homo sapiens	31-39
15358563-4	2004	Taken together, these results suggest that hepcidin action on placenta is mostly through transcriptional downregulation of the iron uptake machinery.	Iron	127-131	hepcidin antimicrobial peptide	Homo sapiens	43-51
15315789-7	2004	This observation underlines the importance of HJV genetic testing, by complete screening of the gene, in young patients with abnormal iron parameters and hypogonadism and/or cardiac symptoms to prevent death from cardiac complications.	Iron	134-138	hemojuvelin BMP co-receptor	Homo sapiens	46-49
15254010-3	2004	The aim of the present study was to determine if mutations in the recently identified HJV gene were associated with more severe iron overload phenotypes in C282Y homozygous patients.	Iron	128-132	hemojuvelin BMP co-receptor	Homo sapiens	86-89
15254010-7	2004	We have recently reported that mutations in the gene that encodes hepcidin (HAMP) could explain one part of the C282Y/C282Y-related phenotypic heterogeneity by accentuating the iron burden.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	66-74
15254010-7	2004	We have recently reported that mutations in the gene that encodes hepcidin (HAMP) could explain one part of the C282Y/C282Y-related phenotypic heterogeneity by accentuating the iron burden.	Iron	177-181	hepcidin antimicrobial peptide	Homo sapiens	76-80
15296486-4	2004	DESIGN: Female weanling Wistar/NIN rats received a control or a 50% mineral-restricted (MR) diet for 12 weeks, by which time MR rats had lower plasma Fe, Zn, Mg and Ca concentrations.	Iron	8-10	ninein	Rattus norvegicus	31-34
15211518-2	2004	Adrenodoxin reductase homologue (Arh1) and yeast adrenodoxin homologue (Yah1) are essential Saccharomyces cerevisiae mitochondrial proteins involved in heme A biosynthesis and in iron-sulfur cluster (FeSC) assembly.	Iron	179-183	adrenodoxin	Saccharomyces cerevisiae S288C	72-76
15196967-4	2004	The iron-induced alpha-syn-positive inclusions co-localized largely with ubiquitin, and some of them were positive for nitrotyrosine, lipid, gamma-tubulin and dynein.	Iron	4-8	synuclein alpha	Homo sapiens	17-26
14988066-10	2004	These findings strongly suggest a relationship between Cu and Fe homeostasis in Hep-G2 cells in which Cu accumulation downregulates DMT1 activity.	Iron	62-64	solute carrier family 11 member 2	Homo sapiens	132-136
15529941-4	2004	Recently, other forms of HH that are not related to HFE, but are due to mutations in genes coding iron transport proteins (ferroportin-1, TfR2, hepcidin) have been described.	Iron	98-102	solute carrier family 40 member 1	Homo sapiens	123-136
15529941-4	2004	Recently, other forms of HH that are not related to HFE, but are due to mutations in genes coding iron transport proteins (ferroportin-1, TfR2, hepcidin) have been described.	Iron	98-102	transferrin receptor 2	Homo sapiens	138-142
15529941-4	2004	Recently, other forms of HH that are not related to HFE, but are due to mutations in genes coding iron transport proteins (ferroportin-1, TfR2, hepcidin) have been described.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	144-152
15223008-3	2004	Divalent metal transport protein (DMT1) on the apical surface of duodenal enterocytes is recognised as the major iron import protein.	Iron	113-117	doublesex and mab-3 related transcription factor 1	Homo sapiens	34-38
15223008-4	2004	We investigated whether genetic variability within the DMT1 gene may partly explain the phenotypic variability seen amongst a group of C282Y homozygotes with iron overload.	Iron	158-162	doublesex and mab-3 related transcription factor 1	Homo sapiens	55-59
15207800-1	2004	BACKGROUND: Abnormal interactions of copper or iron in the brain with metal-binding proteins (such as amyloid-beta peptide [Abeta] or neuromelanin) that lead to oxidative stress have emerged as important potential mechanisms in brain ageing and neurodegenerative disorders.	Iron	47-51	amyloid beta (A4) precursor protein	Mus musculus	124-129
15213303-2	2004	Heme oxygenase-1 (HO-1), which degrades heme into biliverdin, free iron (Fe(2+)), and carbon monoxide (CO), has also been known to have antiproliferative and antiapoptotic effects.	Iron	67-71	heme oxygenase 1	Homo sapiens	0-16
15213303-2	2004	Heme oxygenase-1 (HO-1), which degrades heme into biliverdin, free iron (Fe(2+)), and carbon monoxide (CO), has also been known to have antiproliferative and antiapoptotic effects.	Iron	67-71	heme oxygenase 1	Homo sapiens	18-22
15182858-5	2004	Blocking the iron-driven generation of lipid peroxides and hydroxyl radicals by different iron chelators led to a decrease in UVA-induced MMP-1 mRNA accumulation.	Iron	13-17	matrix metallopeptidase 1	Homo sapiens	138-143
15182858-5	2004	Blocking the iron-driven generation of lipid peroxides and hydroxyl radicals by different iron chelators led to a decrease in UVA-induced MMP-1 mRNA accumulation.	Iron	90-94	matrix metallopeptidase 1	Homo sapiens	138-143
14766669-8	2004	Finally, a role for nonmitochondrial-derived ROS with exposure to high levels of asbestos (50 microg/cm(2)) was suggested by our findings that an iron chelator (phytic acid or deferoxamine) or a free radical scavenger (sodium benzoate) provided additional protection against asbestos-induced caspase-9 activation and DNA fragmentation in rho(omicron) cells.	Iron	146-150	caspase 9	Homo sapiens	292-301
15147384-7	2004	We discuss the phenotype of this sibling pair from precedent biological and clinical findings as well as the expected role of TFR2 in iron homeostasis.	Iron	134-138	transferrin receptor 2	Homo sapiens	126-130
15147384-8	2004	Finally, we suggest that iron overload phenotypes associated with mutations in TFR2 may be intermediate between those related to mutations in HFE and those related to mutations in juvenile hemochromatosis genes.	Iron	25-29	transferrin receptor 2	Homo sapiens	79-83
15346644-2	2004	Paradoxically, recent experimental studies indicate that cellular GGT may also be involved in the generation of reactive oxygen species in the presence of iron or other transition metals.	Iron	155-159	gamma-glutamyltransferase light chain family member 3	Homo sapiens	66-69
15346644-4	2004	For example, serum and dietary antioxidant vitamins had inverse, dose-response relations to serum GGT level within its normal range, whereas dietary heme iron was positively related to serum GGT level.	Iron	154-158	gamma-glutamyltransferase light chain family member 3	Homo sapiens	191-194
15134455-1	2004	Iron transport across the periplasmic space to the cytoplasmic membrane of certain Gram-negative bacteria is mediated by a ferric binding protein (Fbp).	Iron	0-4	folate receptor beta	Homo sapiens	123-145
15134455-1	2004	Iron transport across the periplasmic space to the cytoplasmic membrane of certain Gram-negative bacteria is mediated by a ferric binding protein (Fbp).	Iron	0-4	folate receptor beta	Homo sapiens	147-150
14993228-3	2004	The list includes several key genes in copper and iron homeostasis, such as CCC2, RCS1, FET3, LYS7, and CTR1.	Iron	50-54	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	104-108
14993228-5	2004	The beneficial effect of overexpression of CTR1 requires a functional high affinity iron transport system, as it was abolished by deletion of FET3, a component of the high affinity transport system, or CCC2, which is required for assembly of the transport system.	Iron	84-88	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	43-47
15081867-8	2004	Consistent with these findings, activation of the apoptotic caspases 9 and 3 was blocked in cells pre-treated with either iron or zinc.	Iron	122-126	caspase 9	Homo sapiens	60-76
15190962-1	2004	OBJECTIVE: We aimed to quantify concentrations of inducible heme oxygenase (HO)-1 in the lungs of patients with acute respiratory distress syndrome (ARDS) and to investigate its role as a source of ferrous iron and as a signaling agent for iron regulation.	Iron	206-210	heme oxygenase 1	Homo sapiens	60-81
15190962-1	2004	OBJECTIVE: We aimed to quantify concentrations of inducible heme oxygenase (HO)-1 in the lungs of patients with acute respiratory distress syndrome (ARDS) and to investigate its role as a source of ferrous iron and as a signaling agent for iron regulation.	Iron	240-244	heme oxygenase 1	Homo sapiens	60-81
15081108-4	2004	With regard to iron metabolism, we showed that HEPH, SLC11A2, SLC11A3, and TF are significantly up-regulated, while ATP7B and SLC39A1 (and SFT) are down-regulated and ACO1, dCYTb, FECH, and FTH1 show constant expression.	Iron	15-19	solute carrier family 11 member 2	Homo sapiens	53-60
15081108-4	2004	With regard to iron metabolism, we showed that HEPH, SLC11A2, SLC11A3, and TF are significantly up-regulated, while ATP7B and SLC39A1 (and SFT) are down-regulated and ACO1, dCYTb, FECH, and FTH1 show constant expression.	Iron	15-19	solute carrier family 40 member 1	Homo sapiens	62-69
15086901-1	2004	BACKGROUND: Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to bilirubin, carbon monoxide (CO), and free iron, thus controlling the level of cellular heme.	Iron	114-118	heme oxygenase 1	Homo sapiens	12-28
15086901-1	2004	BACKGROUND: Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to bilirubin, carbon monoxide (CO), and free iron, thus controlling the level of cellular heme.	Iron	114-118	heme oxygenase 1	Homo sapiens	30-34
15086920-10	2004	Left ventricular tissue abundance of p22(phox) subunit of NAD(P)H oxidase was elevated in CRF group and was not affected, whereas p67(phox) subunit abundance was raised by prior iron administration.	Iron	178-182	methionyl aminopeptidase 2	Rattus norvegicus	130-133
15067050-1	2004	Heme oxygenase-1 (HO-1) catabolizes heme into CO, biliverdin, and free iron and serves as a protective enzyme by virtue of its anti-inflammatory, antiapoptotic, and antiproliferative actions.	Iron	71-75	heme oxygenase 1	Homo sapiens	0-16
15067050-1	2004	Heme oxygenase-1 (HO-1) catabolizes heme into CO, biliverdin, and free iron and serves as a protective enzyme by virtue of its anti-inflammatory, antiapoptotic, and antiproliferative actions.	Iron	71-75	heme oxygenase 1	Homo sapiens	18-22
14742448-0	2004	Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide.	Iron	137-141	synuclein alpha	Homo sapiens	0-15
14742448-3	2004	We investigated the role of transferrin receptor (TfR) and iron in modulating the expression of alpha-synuclein (alpha-syn) in MPP(+)-induced oxidative stress and apoptosis.	Iron	59-63	synuclein alpha	Homo sapiens	96-111
14742448-3	2004	We investigated the role of transferrin receptor (TfR) and iron in modulating the expression of alpha-synuclein (alpha-syn) in MPP(+)-induced oxidative stress and apoptosis.	Iron	59-63	synuclein alpha	Homo sapiens	96-105
14742448-8	2004	We conclude that MPP(+)-induced iron signaling is responsible for intracellular oxidant generation, alpha-syn expression, proteasomal dysfunction, and apoptosis.	Iron	32-36	synuclein alpha	Homo sapiens	100-109
15051603-9	2004	Among possible meat constituents, dietary heme iron, but not saturated fat, was associated with GGT.	Iron	47-51	gamma-glutamyltransferase light chain family member 3	Homo sapiens	96-99
15051603-13	2004	Heme iron contained in meats and micronutrients contained in fruits may influence GGT metabolism.	Iron	5-9	gamma-glutamyltransferase light chain family member 3	Homo sapiens	82-85
15080300-7	2004	RET-Y is correlated closely with CHr and is useful for diagnosis and early monitoring after the administration of intravenous iron.	Iron	126-130	ret proto-oncogene	Homo sapiens	0-3
14670915-10	2004	Based on a digenic model of inheritance, these data suggest that the association of heterozygous mutations in the HFE and HAMP genes could lead, at least in some cases, to an adult-onset form of primary iron overload.	Iron	203-207	hepcidin antimicrobial peptide	Homo sapiens	122-126
15015967-6	2004	Only TfR2 expression was significantly associated with either serum iron (r = -0.270, P = 0.045) or serum ferritin (r = -0.364, P = 0.008).	Iron	68-72	transferrin receptor 2	Homo sapiens	5-9
15015967-9	2004	The present study suggests that (i) TfRs-independent iron uptake might have an important role in in vivo proliferation of AML cells; (ii) expression of TfR2 (especially the alpha form) is a novel prognostic factor for patients with AML.	Iron	53-57	transferrin receptor 2	Homo sapiens	152-156
15075083-0	2004	The impact of the mutations of the HFE gene and of the SLC11A3 gene on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients.	Iron	71-75	solute carrier family 40 member 1	Homo sapiens	55-62
15024747-1	2004	Hepcidin is a recently identified hormone peptide involved in regulation of iron homeostasis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	0-8
15024747-2	2004	HAMP gene mutations have been described to date in five families with iron overload.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	0-4
14988035-0	2004	Lysosomal deposition of Abeta in cultures of brain vascular smooth muscle cells is enhanced by iron.	Iron	95-99	amyloid beta (A4) precursor protein	Mus musculus	24-29
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	25-29	doublesex and mab-3 related transcription factor 1	Homo sapiens	72-76
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	25-29	solute carrier family 40 member 1	Homo sapiens	78-83
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	25-29	metallothionein 1B	Homo sapiens	85-88
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	25-29	solute carrier family 36 member 1	Homo sapiens	90-94
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	25-29	solute carrier family 40 member 1	Homo sapiens	131-138
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	25-29	solute carrier family 40 member 1	Homo sapiens	146-150
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	58-62	doublesex and mab-3 related transcription factor 1	Homo sapiens	72-76
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	78-83
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	58-62	metallothionein 1B	Homo sapiens	85-88
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	58-62	solute carrier family 36 member 1	Homo sapiens	90-94
14699112-4	2004	To access the mechanism of Fe-phytosiderophore acquisition, ZmYS1 was expressed in an iron uptake-defective yeast mutant and in Xenopus oocytes, where ZmYS1-dependent Fe-phytosiderophore transport was stimulated at acidic pH and sensitive to CCCP.	Iron	167-169	iron-phytosiderophore transporter yellow stripe 1	Zea mays	60-65
14699112-4	2004	To access the mechanism of Fe-phytosiderophore acquisition, ZmYS1 was expressed in an iron uptake-defective yeast mutant and in Xenopus oocytes, where ZmYS1-dependent Fe-phytosiderophore transport was stimulated at acidic pH and sensitive to CCCP.	Iron	167-169	iron-phytosiderophore transporter yellow stripe 1	Zea mays	151-156
14699112-8	2004	Our results show that ZmYS1 encodes a proton-coupled broad-range metal-phytosiderophore transporter that additionally transports Fe- and Ni-nicotianamine.	Iron	129-132	iron-phytosiderophore transporter yellow stripe 1	Zea mays	22-27
15020277-0	2004	Homozygosity for transferrin receptor-2 Y250X mutation induces early iron overload.	Iron	69-73	transferrin receptor 2	Homo sapiens	17-39
15020277-3	2004	We suggest that transferrin receptor-2 is important in maintaining iron balance in the first decades of life.	Iron	67-71	transferrin receptor 2	Homo sapiens	16-38
14735461-1	2004	Heme oxygenase-1 (HO-1), an inducible enzyme that catalyzes oxidative degradation of heme to form biliverdin, carbon monoxide and free iron, may protect tumor cells against oxidative stress, thus contributing to rapid tumor growth in vivo.	Iron	135-139	heme oxygenase 1	Homo sapiens	18-22
14762804-0	2004	Hepcidin in HFE-associated hemochromatosis: another piece of the "iron" puzzle.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	0-8
14968347-8	2004	HO-1 induction subsequently led to a marked increase in protein expression of a second antioxidant protein, ferritin, via the HO-1-dependent release of free iron from endogenous heme sources (Figures 1 and 5).	Iron	157-161	heme oxygenase 1	Homo sapiens	0-4
14968347-8	2004	HO-1 induction subsequently led to a marked increase in protein expression of a second antioxidant protein, ferritin, via the HO-1-dependent release of free iron from endogenous heme sources (Figures 1 and 5).	Iron	157-161	heme oxygenase 1	Homo sapiens	126-130
14742502-6	2004	In addition, infection experiments demonstrated virulence attenuation when this mutant was administered intraperitoneally or subcutaneously to both normal and iron-treated mice, indicating that TrkA may modulate the transport of potassium and resistance to host innate defenses and that it is important for virulence in mice.	Iron	159-163	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	194-198
14981211-7	2004	Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin).	Iron	23-27	lactotransferrin	Mus musculus	314-330
14739928-2	2004	FRE2 encoding a plasma membrane ferric reductase is induced by the iron-responsive, DNA-binding, transcriptional activator Aft1.	Iron	67-71	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	0-4
15014911-3	2004	The functional properties and localization in plasma membrane of cells and endosomes suggest an important role for the divalent metal transporter DMT1 (also known as DCT1 and Nramp2) in iron transport and cellular iron homeostasis.	Iron	214-218	solute carrier family 11 member 2	Homo sapiens	166-170
15014911-3	2004	The functional properties and localization in plasma membrane of cells and endosomes suggest an important role for the divalent metal transporter DMT1 (also known as DCT1 and Nramp2) in iron transport and cellular iron homeostasis.	Iron	214-218	solute carrier family 11 member 2	Homo sapiens	175-181
15014911-4	2004	Although iron metabolism is strictly controlled and the activity of DMT1 is central in controlling iron homeostasis, no regulatory mechanisms for DMT1 have been so far identified.	Iron	99-103	solute carrier family 11 member 2	Homo sapiens	68-72
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	51-58
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	116-128
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	129-134
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	84-88	solute carrier family 40 member 1	Homo sapiens	135-139
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	207-211	solute carrier family 40 member 1	Homo sapiens	51-58
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	207-211	solute carrier family 40 member 1	Homo sapiens	116-128
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	207-211	solute carrier family 40 member 1	Homo sapiens	129-134
14757427-2	2004	The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene.	Iron	207-211	solute carrier family 40 member 1	Homo sapiens	135-139
15506716-3	2004	Systemic iron overload is also associated with aceruloplasminemia, atransferrinemia and the "Gracile" syndrome caused by mutations in BCS1L.	Iron	9-13	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	134-139
14729598-10	2004	These inhibition studies showed that the iron center and tyrosyl radical are involved in RR activity for both p53R2 and hRRM2.	Iron	41-45	ribonucleotide reductase regulatory subunit M2	Homo sapiens	120-125
14575744-5	2004	In particular, results from batch and column experiments show that ABS based on these materials can efficiently demobilise iron and manganese from percolating, anoxic pore water by cation exchange under favourable conditions.	Iron	123-127	DEAD-box helicase 41	Homo sapiens	67-70
14683741-1	2004	AIMS: Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme degradation, leading to the generation of free iron, biliverdin, and carbon monoxide (CO).	Iron	111-115	heme oxygenase 1	Homo sapiens	6-22
14683741-1	2004	AIMS: Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme degradation, leading to the generation of free iron, biliverdin, and carbon monoxide (CO).	Iron	111-115	heme oxygenase 1	Homo sapiens	24-28
14704284-0	2004	Hepcidin, the recently identified peptide that appears to regulate iron absorption.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	0-8
14704284-1	2004	A newly identified iron regulator, hepcidin, appears to communicate body iron status and demand for erythropoiesis to the intestine, and in turn, modulates intestinal iron absorption.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	35-43
14704284-1	2004	A newly identified iron regulator, hepcidin, appears to communicate body iron status and demand for erythropoiesis to the intestine, and in turn, modulates intestinal iron absorption.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	35-43
14704284-1	2004	A newly identified iron regulator, hepcidin, appears to communicate body iron status and demand for erythropoiesis to the intestine, and in turn, modulates intestinal iron absorption.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	35-43
14704284-5	2004	These observations support the role of hepcidin as a signal that limits intestinal iron absorption.	Iron	83-87	hepcidin antimicrobial peptide	Homo sapiens	39-47
14704284-7	2004	Thus, the relationship between body iron status and hepcidin is altered in hemochromatosis patients.	Iron	36-40	hepcidin antimicrobial peptide	Homo sapiens	52-60
14704284-11	2004	However, much remains to be investigated in the regulation of hepcidin by iron, hypoxia and inflammation.	Iron	74-78	hepcidin antimicrobial peptide	Homo sapiens	62-70
14765739-1	2004	Lactoferrin (LF) is an iron-binding protein present in both colostrum and secondary granules of polymorphonuclear neutrophils (PMNs).	Iron	23-27	lactotransferrin	Bos taurus	0-11
14765739-1	2004	Lactoferrin (LF) is an iron-binding protein present in both colostrum and secondary granules of polymorphonuclear neutrophils (PMNs).	Iron	23-27	lactotransferrin	Bos taurus	13-15
14647275-0	2004	Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.	Iron	24-28	hemojuvelin BMP co-receptor	Homo sapiens	13-17
14647275-8	2004	HFE2 transcript expression was restricted to liver, heart and skeletal muscle, similar to that of hepcidin, a key protein implicated in iron metabolism.	Iron	136-140	hemojuvelin BMP co-receptor	Homo sapiens	0-4
14647275-8	2004	HFE2 transcript expression was restricted to liver, heart and skeletal muscle, similar to that of hepcidin, a key protein implicated in iron metabolism.	Iron	136-140	hepcidin antimicrobial peptide	Homo sapiens	98-106
15077953-1	2004	A laponite RD clay-based Fe nanocomposite (Fe-Lap-RD) has been synthesized by the so-called pillaring technique.	Iron	25-27	LAP	Homo sapiens	46-49
12791678-0	2003	Superoxide-dependent iron uptake: a new role for anion exchange protein 2.	Iron	21-25	solute carrier family 4 member 2	Homo sapiens	49-73
12791678-2	2003	We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-reductase activity involving anion exchange protein 2 (AE2) and extracellular bicarbonate (HCO3-).	Iron	98-102	solute carrier family 4 member 2	Homo sapiens	172-196
12791678-2	2003	We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-reductase activity involving anion exchange protein 2 (AE2) and extracellular bicarbonate (HCO3-).	Iron	98-102	solute carrier family 4 member 2	Homo sapiens	198-201
14697078-0	2003	[Hepcidin, a new protein of body iron homeostasis].	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	1-9
14633868-0	2003	Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload.	Iron	162-166	transferrin receptor 2	Homo sapiens	58-80
14636286-8	2003	RESULTS: In in vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P &lt; 0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P &lt; 0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P &lt; 0.001).	Iron	32-36	L1 cell adhesion molecule	Mus musculus	178-182
14636286-8	2003	RESULTS: In in vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P &lt; 0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P &lt; 0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P &lt; 0.001).	Iron	32-36	L1 cell adhesion molecule	Mus musculus	293-297
14636286-8	2003	RESULTS: In in vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P &lt; 0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P &lt; 0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P &lt; 0.001).	Iron	32-36	L1 cell adhesion molecule	Mus musculus	293-297
14636286-8	2003	RESULTS: In in vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P &lt; 0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P &lt; 0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P &lt; 0.001).	Iron	32-36	L1 cell adhesion molecule	Mus musculus	293-297
14636286-10	2003	Iron used in vitro at concentration 0.0001 mg mL-1 and greater induces generation of oxygen-derived free radicals in mesothelial cells.	Iron	0-4	L1 cell adhesion molecule	Mus musculus	46-50
13129917-9	2003	We also present evidence that AtOPT3, a member of the oligopeptide transporter gene family with significant similarities to the maize iron-phytosiderophore transporter YS1, is regulated by metals and heterologous expression AtOPT3 can rescue yeast mutants deficient in metal transport.	Iron	134-138	iron-phytosiderophore transporter yellow stripe 1	Zea mays	168-171
12928433-3	2003	We found that the absence of heme, due to a deletion in the gene that encodes delta-aminolevulinic acid synthase (HEM1), resulted in decreased transcription of genes belonging to both the iron and copper regulons, but not the zinc regulon.	Iron	188-192	5-aminolevulinate synthase	Saccharomyces cerevisiae S288C	114-118
12760904-1	2003	Release of iron from enterocytes and hepatocytes is thought to require the copper-dependent ferroxidase activity of hephaestin (Hp) and ceruloplasmin (Cp), respectively.	Iron	11-15	hephaestin	Rattus norvegicus	116-126
14620767-6	2003	Virulent R equi were able to use iron from ferrated deferoxamine, bovine transferrin, and bovine lactoferrin.	Iron	33-37	lactotransferrin	Bos taurus	97-108
14620767-7	2003	Only virulent R equi expressed an iron-regulated, immunogenic, surface-associated protein identified as VapA.	Iron	34-38	virulence-associated 15-17 kDa antigen	Rhodococcus equi	104-108
14620767-10	2003	Expression of VapA is substantially upregulated when there is a limited amount of available iron.	Iron	92-96	virulence-associated 15-17 kDa antigen	Rhodococcus equi	14-18
12921533-9	2003	Inhibition of endocytosis or deletion of both the vacuolar iron transporters ( SMF3 and FET5 / FTH1 ) prevented hephaestin from complementing the low-iron growth phenotype of Delta fet3 cells, suggesting that hephaestin is functioning within the endocytic apparatus.	Iron	59-63	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	79-83
14636642-0	2003	Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	86-99
14636642-1	2003	The product of the SLC40A1 gene, ferroportin 1, is a main iron export protein.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	19-26
14636642-1	2003	The product of the SLC40A1 gene, ferroportin 1, is a main iron export protein.	Iron	58-62	solute carrier family 40 member 1	Homo sapiens	33-46
14636642-2	2003	Pathogenic mutations in ferroportin 1 lead to an autosomal dominant hereditary iron overload syndrome characterized by high serum ferritin concentration, normal transferrin saturation, iron accumulation predominantly in macrophages, and marginal anemia.	Iron	79-83	solute carrier family 40 member 1	Homo sapiens	24-37
14636642-4	2003	We analyzed the ferroportin 1 gene in 19 unrelated patients from southern Africa (N = 15) and the United States (N = 4) presenting with primary iron overload.	Iron	144-148	solute carrier family 40 member 1	Homo sapiens	16-29
14636642-10	2003	We conclude that the Q248H mutation is a common polymorphism in the ferroportin 1 gene in African populations that may be associated with mild anemia and a tendency to iron loading.	Iron	168-172	solute carrier family 40 member 1	Homo sapiens	68-81
14636643-0	2003	Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans.	Iron	48-52	solute carrier family 40 member 1	Homo sapiens	0-13
12840021-2	2003	The Nramp1 promoter is TATA box-deficient, has two initiator elements, and is repressed by c-Myc, in accordance with the notion that genes that deplete the iron content of the cell cytosol antagonize cell growth.	Iron	156-160	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	4-10
12915448-7	2003	The presence of a NifU-like domain in the HIRIP5 protein raises an interesting possibility that it may be involved in iron homeostasis.	Iron	118-122	NFU1 iron-sulfur cluster scaffold	Homo sapiens	42-48
14566387-2	2003	It was shown that LF, not depending on the source of its obtaining, is an efficient iron chelator and decreases intensity of peroxidative processes.	Iron	84-88	lactotransferrin	Bos taurus	18-20
12915468-6	2003	We have detected two new HAMP mutations in two different families, in which there is concordance between severity of iron overload and heterozygosity for HAMP mutations when present with the HFE C282Y mutation.	Iron	117-121	hepcidin antimicrobial peptide	Homo sapiens	25-29
12915468-13	2003	We propose that the phenotype of C282Y heterozygotes and homozygotes may be modified by heterozygosity for mutations which disrupt the function of hepcidin in iron homeostasis, with the severity of iron overload corresponding to the severity of the HAMP mutation.	Iron	159-163	hepcidin antimicrobial peptide	Homo sapiens	147-155
12915468-13	2003	We propose that the phenotype of C282Y heterozygotes and homozygotes may be modified by heterozygosity for mutations which disrupt the function of hepcidin in iron homeostasis, with the severity of iron overload corresponding to the severity of the HAMP mutation.	Iron	198-202	hepcidin antimicrobial peptide	Homo sapiens	147-155
12915468-13	2003	We propose that the phenotype of C282Y heterozygotes and homozygotes may be modified by heterozygosity for mutations which disrupt the function of hepcidin in iron homeostasis, with the severity of iron overload corresponding to the severity of the HAMP mutation.	Iron	198-202	hepcidin antimicrobial peptide	Homo sapiens	249-253
12937832-8	2003	In the presence of transferrin, low K(+) enhanced cellular uptake of iron approximately by 70%.	Iron	69-73	inhibitor of carbonic anhydrase	Canis lupus familiaris	19-30
12937832-11	2003	The effect of transferrin is mediated by increased iron transport.	Iron	51-55	inhibitor of carbonic anhydrase	Canis lupus familiaris	14-25
12756240-2	2003	The results of in vivo and in organellar experiments indicate that the Hsp70 Ssq1 and the J-protein Jac1 function together to assist in the biogenesis of iron-sulfur (Fe/S) centers in the mitochondrial matrix.	Iron	154-158	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	100-104
12756240-2	2003	The results of in vivo and in organellar experiments indicate that the Hsp70 Ssq1 and the J-protein Jac1 function together to assist in the biogenesis of iron-sulfur (Fe/S) centers in the mitochondrial matrix.	Iron	167-169	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	100-104
12756240-7	2003	These findings are consistent with the role in Fe/S biogenesis previously proposed for the bacterial Hsp70 Hsc66 and J-protein Hsc20 that interact with the bacterial Isu homologue IscU.	Iron	47-49	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	127-132
12663437-0	2003	Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
12663437-2	2003	The synthesis of hepcidin is greatly stimulated by inflammation or by iron overload.	Iron	70-74	hepcidin antimicrobial peptide	Homo sapiens	17-25
12663437-5	2003	Recent evidence shows that deficient hepcidin response to iron loading may contribute to iron overload even in the much milder common form of hemochromatosis, from mutations in the HFE gene.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	37-45
12663437-5	2003	Recent evidence shows that deficient hepcidin response to iron loading may contribute to iron overload even in the much milder common form of hemochromatosis, from mutations in the HFE gene.	Iron	89-93	hepcidin antimicrobial peptide	Homo sapiens	37-45
12663437-6	2003	In anemia of inflammation, hepcidin production is increased up to 100-fold and this may account for the defining feature of this condition, sequestration of iron in macrophages.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	27-35
12663437-7	2003	The discovery of hepcidin and its role in iron metabolism could lead to new therapies for hemochromatosis and anemia of inflammation.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	17-25
12932241-8	2003	CONCLUSIONS: The cellular iron pool and hydroxyl radicals were the most important determining factors for the total amount of MDA produced after a given UVA1 dose, and PHGPx overexpression had the greatest protective effect against LPO.	Iron	26-30	glutathione peroxidase 4	Homo sapiens	168-173
12950389-2	2003	In order to elucidate the mechanisms involved in apoptosis induction by iron deprivation, we studied the expression of p53 and the expression of selected p53-regulated genes.	Iron	72-76	transformation related protein 53, pseudogene	Mus musculus	154-157
14626560-0	2003	[Hepcidin--a peptide regulating the quantity and distribution of iron in the body in healthy and disease states].	Iron	65-69	hepcidin antimicrobial peptide	Homo sapiens	1-9
14626560-3	2003	Antimicrobial peptide hepcidin, produced in the liver, is considered as a key regulator of iron absorption and kinetics in the organism.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	22-30
14626560-5	2003	Hepcidin decreases iron absorption in the duodenum and causes its sequestration in macrophages.	Iron	19-23	hepcidin antimicrobial peptide	Homo sapiens	0-8
14626560-7	2003	Hepcidin is not only the physiological regulator of iron kinetics but is supposed to be a part of the pathogenetic mechanism of anaemia accompanying chronic diseases and its relationship to the hereditary hemochromatosis is also studied.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
12873829-0	2003	Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	18-31
12873829-1	2003	We report a family affected with dominant autosomal iron overload related to a new mutation in ferroportin 1, a transmembrane protein involved in the export of iron from duodenal enterocytes and likely from macrophages.	Iron	52-56	solute carrier family 40 member 1	Homo sapiens	95-108
12873829-1	2003	We report a family affected with dominant autosomal iron overload related to a new mutation in ferroportin 1, a transmembrane protein involved in the export of iron from duodenal enterocytes and likely from macrophages.	Iron	160-164	solute carrier family 40 member 1	Homo sapiens	95-108
12913155-4	2003	In contrast, ZmNAS3 was expressed under Fe-sufficient conditions, and was negatively regulated by Fe deficiency.	Iron	40-42	nicotianamine synthase 3	Zea mays	13-19
14580148-2	2003	Heme degradation is catalyzed by the two isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, eventually yielding biliverdin/bilirubin, CO, and iron.	Iron	153-157	heme oxygenase 1	Homo sapiens	69-85
14580148-2	2003	Heme degradation is catalyzed by the two isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, eventually yielding biliverdin/bilirubin, CO, and iron.	Iron	153-157	heme oxygenase 1	Homo sapiens	87-91
12847289-2	2003	Myoglobin (Mb) is the paradigm to investigate conformational dynamics because it is a simple globular heme protein displaying a photosensitivity of the iron-ligand bond.	Iron	152-156	myoglobin	Homo sapiens	0-9
12743117-0	2003	Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system.	Iron	68-72	ceruloplasmin	Homo sapiens	38-51
12743117-1	2003	Ceruloplasmin (Cp) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric form.	Iron	71-75	ceruloplasmin	Homo sapiens	0-13
12743117-7	2003	We also provide evidence that the divalent metal influx transporter DMT1 is expressed by astrocytes and is likely to mediate iron influx into these glial cells.	Iron	125-129	solute carrier family 11 member 2	Homo sapiens	68-72
12743117-8	2003	The coordinated actions of GPI-Cp and IREG1 may be required for iron efflux from neural cells, and disruption of this balance could lead to iron accumulation in the central nervous system and neurodegeneration.	Iron	64-68	solute carrier family 40 member 1	Homo sapiens	38-43
12743117-8	2003	The coordinated actions of GPI-Cp and IREG1 may be required for iron efflux from neural cells, and disruption of this balance could lead to iron accumulation in the central nervous system and neurodegeneration.	Iron	140-144	solute carrier family 40 member 1	Homo sapiens	38-43
12724326-1	2003	Nramp2 (natural resistance-associated macrophage protein 2, also called DMT1 and Slc11a2) is a proton-dependent cation transporter, which plays a central role in iron homeostasis.	Iron	162-166	solute carrier family 11 member 2	Homo sapiens	0-6
12724326-1	2003	Nramp2 (natural resistance-associated macrophage protein 2, also called DMT1 and Slc11a2) is a proton-dependent cation transporter, which plays a central role in iron homeostasis.	Iron	162-166	solute carrier family 11 member 2	Homo sapiens	8-58
12724326-1	2003	Nramp2 (natural resistance-associated macrophage protein 2, also called DMT1 and Slc11a2) is a proton-dependent cation transporter, which plays a central role in iron homeostasis.	Iron	162-166	solute carrier family 11 member 2	Homo sapiens	72-76
12724326-1	2003	Nramp2 (natural resistance-associated macrophage protein 2, also called DMT1 and Slc11a2) is a proton-dependent cation transporter, which plays a central role in iron homeostasis.	Iron	162-166	solute carrier family 11 member 2	Homo sapiens	81-88
12724326-10	2003	Their subcellular colocalization and parallel trafficking suggest that Nramp2 and transferrin receptors are functionally coupled to effect pH-dependent iron uptake across the endosomal membrane.	Iron	152-156	solute carrier family 11 member 2	Homo sapiens	71-77
12814879-13	2003	The most important sink for dissolved S(-II) produced by the enzymatic reduction of SO(4) was its direct reaction with solid-phase Fe(III) hydroxides leading initially to the formation of FeS.	Iron	188-191	transcription elongation factor A1	Homo sapiens	38-43
12840181-1	2003	In developed countries where meat is an important constituent of the diet, much of the dietary iron is in the heme-iron form as hemoglobin and myoglobin.	Iron	95-99	myoglobin	Homo sapiens	143-152
12734107-2	2003	DMT1, also known as Nramp2 and DCT1, is the transporter responsible for intestinal iron uptake.	Iron	83-87	solute carrier family 11 member 2	Homo sapiens	0-4
12734107-5	2003	Treatment of cells with a DMT1 antisense oligonucleotide resulted in 80 and 48% inhibition of iron and copper uptake, respectively.	Iron	94-98	solute carrier family 11 member 2	Homo sapiens	26-30
12734107-11	2003	These results demonstrate that DMT1 is a physiologically relevant Cu(1+) transporter in intestinal cells, indicating that intestinal absorption of copper and iron are intertwined.	Iron	158-162	solute carrier family 11 member 2	Homo sapiens	31-35
12846986-1	2003	Accumulation and toxic conversion to protofibrils of alpha-synuclein has been associated with neurological disorders such as Parkinson"s disease (PD), Lewy body disease, multiple system atrophy, neurodegeneration with brain iron accumulation type 1, and Alzheimer"s disease.	Iron	224-228	synuclein, alpha	Mus musculus	53-68
12777486-11	2003	A C. albicans ctr1-null mutant displays phenotypes consistent with the lack of copper uptake including growth defects in low-copper and low-iron conditions, a respiratory deficiency and sensitivity to oxidative stress.	Iron	140-144	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	14-18
12739969-2	2003	The mu2-silylene-bridged iron complexes [Cp(OC)(2)Fe](2)SiX(2) (X = F (2), Br (4), I (5)) have been prepared from the mu2-SiH(2) functional precursor [Cp(OC)(2)Fe](2)SiH(2) (1) by hydrogen/halogen exchange, using HBF(4), CBr(4), and CH(2)I(2), respectively.	Iron	25-29	carbonyl reductase 4	Homo sapiens	221-226
12793906-3	2003	Recent studies from our laboratory described gamma-glutamyltransferase activity (GGT) as a factor capable to effect iron reduction in the cell microenvironment.	Iron	116-120	gamma-glutamyltransferase light chain family member 3	Homo sapiens	81-84
12793906-5	2003	The present study was aimed at verifying the possibility that GGT-mediated iron reduction may participate in the process of cellular iron uptake.	Iron	75-79	gamma-glutamyltransferase light chain family member 3	Homo sapiens	62-65
12793906-5	2003	The present study was aimed at verifying the possibility that GGT-mediated iron reduction may participate in the process of cellular iron uptake.	Iron	133-137	gamma-glutamyltransferase light chain family member 3	Homo sapiens	62-65
12793906-8	2003	Transferrin-independent iron uptake was investigated using 55Fe complexed by nitrilotriacetic acid (55Fe-NTA complex).The stimulation of GGT activity, by administration to cells of the substrates glutathione and glycyl-glycine, was generally reflected in a facilitation of transferrin-bound iron uptake.	Iron	24-28	gamma-glutamyltransferase light chain family member 3	Homo sapiens	137-140
12793906-8	2003	Transferrin-independent iron uptake was investigated using 55Fe complexed by nitrilotriacetic acid (55Fe-NTA complex).The stimulation of GGT activity, by administration to cells of the substrates glutathione and glycyl-glycine, was generally reflected in a facilitation of transferrin-bound iron uptake.	Iron	291-295	gamma-glutamyltransferase light chain family member 3	Homo sapiens	137-140
12793906-10	2003	Accordingly, inhibition of GGT activity by means of two independent inhibitors, acivicin and serine/boric acid complex, resulted in a decreased uptake of transferrin-bound iron.	Iron	172-176	gamma-glutamyltransferase light chain family member 3	Homo sapiens	27-30
12793906-12	2003	CONCLUSION: It is concluded that membrane GGT can represent a facilitating factor in iron uptake by GGT-expressing cancer cells, thus providing them with a selective growth advantage over clones that do not possess the enzyme.	Iron	85-89	gamma-glutamyltransferase light chain family member 3	Homo sapiens	42-45
12793906-12	2003	CONCLUSION: It is concluded that membrane GGT can represent a facilitating factor in iron uptake by GGT-expressing cancer cells, thus providing them with a selective growth advantage over clones that do not possess the enzyme.	Iron	85-89	gamma-glutamyltransferase light chain family member 3	Homo sapiens	100-103
12585963-2	2003	One such protective response is the induction of haem oxygenase 1 (HO-1), which catalyses the rate-limiting step in haem degradation, liberating iron, CO and biliverdin.	Iron	145-149	heme oxygenase 1	Homo sapiens	49-65
12585963-2	2003	One such protective response is the induction of haem oxygenase 1 (HO-1), which catalyses the rate-limiting step in haem degradation, liberating iron, CO and biliverdin.	Iron	145-149	heme oxygenase 1	Homo sapiens	67-71
12585963-4	2003	Either N-acetylcysteine, an antioxidant, or deferoxamine, an iron chelator, resulted in a dose-dependent inhibition of HO-1 mRNA and protein induction during glucose deprivation, suggesting a redox- and iron-dependent mechanism.	Iron	61-65	heme oxygenase 1	Homo sapiens	119-123
12709571-4	2003	The downregulation of HO-1 expression may reduce energy expenditure and local production of carbon monoxide, iron, and bilirubin and transiently increase intracellular heme pool.	Iron	109-113	heme oxygenase 1	Homo sapiens	22-26
12704209-2	2003	The cognate proteins, HFE and TfR2, are therefore of key importance in human iron homeostasis.	Iron	77-81	transferrin receptor 2	Homo sapiens	30-34
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	148-152	transferrin receptor 2	Homo sapiens	31-35
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	148-152	CD63 molecule	Homo sapiens	63-67
12704209-8	2003	In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron.	Iron	305-309	transferrin receptor 2	Homo sapiens	31-35
12730463-0	2003	Ferritin: at the crossroads of iron and oxygen metabolism.	Iron	31-35	ferritin-1, chloroplastic	Glycine max	0-8
12730463-4	2003	Only one protein, ferritin, evolved to concentrate iron to levels needed in aerobic metabolism.	Iron	51-55	ferritin-1, chloroplastic	Glycine max	18-26
12730463-5	2003	Reversible formation and dissolution of a solid nanomineral-hydrated, iron oxide is the main function of ferritin, which additionally detoxifies excess iron and possibly dioxygen and reactive oxygen.	Iron	70-74	ferritin-1, chloroplastic	Glycine max	105-113
12730463-6	2003	Ferritin is a large multifunctional, multisubunit protein with eight Fe transport pores, 12 mineral nucleation sites and up to 24 oxidase sites that produce mineral precursors from ferrous iron and oxygen.	Iron	181-193	ferritin-1, chloroplastic	Glycine max	0-8
12730463-8	2003	Ferritin with varying H/L ratios is related to cell-specific iron and oxygen homeostasis.	Iron	61-65	ferritin-1, chloroplastic	Glycine max	0-8
12730463-9	2003	H-ferritin oxidase activity accelerates rates of iron mineralization in ferritins and, in animals, ferritin produces H(2)O(2) as a byproduct.	Iron	49-53	ferritin-1, chloroplastic	Glycine max	2-10
12730463-9	2003	H-ferritin oxidase activity accelerates rates of iron mineralization in ferritins and, in animals, ferritin produces H(2)O(2) as a byproduct.	Iron	49-53	ferritin-1, chloroplastic	Glycine max	72-80
12730463-10	2003	Properties of ferritin mRNA and ferritin protein pore structure are new targets for manipulating iron homeostasis.	Iron	97-101	ferritin-1, chloroplastic	Glycine max	14-22
12730463-10	2003	Properties of ferritin mRNA and ferritin protein pore structure are new targets for manipulating iron homeostasis.	Iron	97-101	ferritin-1, chloroplastic	Glycine max	32-40
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	51-55	ferritin-1, chloroplastic	Glycine max	67-75
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	51-55	ferritin-1, chloroplastic	Glycine max	117-125
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	51-55	ferritin-1, chloroplastic	Glycine max	117-125
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	126-130	ferritin-1, chloroplastic	Glycine max	117-125
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	126-130	ferritin-1, chloroplastic	Glycine max	117-125
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	126-130	ferritin-1, chloroplastic	Glycine max	117-125
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	126-130	ferritin-1, chloroplastic	Glycine max	117-125
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	126-130	ferritin-1, chloroplastic	Glycine max	117-125
12730463-11	2003	Recent observations of the high bioavailability of iron in soybean ferritin and efficient utilization of soybean and ferritin iron by iron-deficient animals, and of soybean iron by humans with borderline deficiency, indicate a role for ferritin in managing global iron deficiency in humans.	Iron	126-130	ferritin-1, chloroplastic	Glycine max	117-125
12730464-7	2003	Divalent metal transporter 1 (DMT1) mRNA in the iron-responsive element (IRE) regulated, but not the non-IRE regulated form is increased, as is the placenta Cu oxidase.	Iron	48-52	solute carrier family 11 member 2	Homo sapiens	0-28
12730464-7	2003	Divalent metal transporter 1 (DMT1) mRNA in the iron-responsive element (IRE) regulated, but not the non-IRE regulated form is increased, as is the placenta Cu oxidase.	Iron	48-52	solute carrier family 11 member 2	Homo sapiens	30-34
12704390-10	2003	We found unexpected alterations in the expression of Slc39a1 (mouse ortholog of SLC11A3) and Cybrd1, which encode key iron transport proteins, and Hamp (hepcidin antimicrobial peptide), a hepatic regulator of iron transport.	Iron	118-122	solute carrier family 39 (zinc transporter), member 1	Mus musculus	53-60
12704390-10	2003	We found unexpected alterations in the expression of Slc39a1 (mouse ortholog of SLC11A3) and Cybrd1, which encode key iron transport proteins, and Hamp (hepcidin antimicrobial peptide), a hepatic regulator of iron transport.	Iron	209-213	solute carrier family 39 (zinc transporter), member 1	Mus musculus	53-60
12706453-9	2003	Western blot revealed that iron treatment up-regulated the apoptosis-related gene p53 as well as its effector gene p21(waf1/cip1).	Iron	27-31	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	82-85
12679138-1	2003	We have previously shown that pirlindole and dehydropirlindole, two monoamine oxidase type-A inhibitors, protect cultured brain cells against iron-induced toxicity through a mechanism unrelated to monoamine oxidase type-A inhibition.	Iron	142-146	monoamine oxidase A	Homo sapiens	68-92
12433676-1	2003	Hepcidin is a liver-made peptide proposed to be a central regulator of intestinal iron absorption and iron recycling by macrophages.	Iron	82-86	hepcidin antimicrobial peptide	Homo sapiens	0-8
12433676-1	2003	Hepcidin is a liver-made peptide proposed to be a central regulator of intestinal iron absorption and iron recycling by macrophages.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	0-8
12641614-5	2003	The urine concentration of albumin and beta 2-microglobulin, as well as the activity of N-acetyl-beta-D-glucosaminidase (NAG), correlated positively with serum ferritin concentration and liver iron deposition, as detected by MRI T2 values.	Iron	193-197	beta-2-microglobulin	Homo sapiens	39-59
12678694-6	2003	HO1-mediated metabolism of heme groups released from NO-damaged proteins leads to a change in the levels of redox-active iron and a release of carbon monoxide (CO) and bilirubin, all of which have been implicated in cellular resistance to oxidative stress.	Iron	121-125	heme oxygenase 1	Homo sapiens	0-3
12511571-1	2003	Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon monoxide, and bilirubin IXalpha.	Iron	71-75	heme oxygenase 1	Homo sapiens	0-16
12511571-6	2003	Expression of HO-1 was also reduced in human cells when exposed to interferon-gamma or an iron chelator desferrioxamine, each of which induced Bach1 expression.	Iron	90-94	heme oxygenase 1	Homo sapiens	14-18
12572661-3	2003	Iron and copper metabolism have been intertwined for nearly 150 years and the interrelationship is growing with advances in understanding the role of ceruloplasmin as one example and the probable role of hephaestin as another.	Iron	0-4	ceruloplasmin	Homo sapiens	150-163
12572661-4	2003	The transporter DMT1 (divalent metal transporter 1) clearly plays a major part in iron uptake and trafficking.	Iron	82-86	solute carrier family 11 member 2	Homo sapiens	16-20
12572661-4	2003	The transporter DMT1 (divalent metal transporter 1) clearly plays a major part in iron uptake and trafficking.	Iron	82-86	solute carrier family 11 member 2	Homo sapiens	22-50
12572662-17	2003	Studies of two copper proteins, ceruloplasmin and its recently discovered homologue hephaestin, have provided two molecular links connecting the pathways of copper and iron metabolism.	Iron	168-172	ceruloplasmin	Homo sapiens	32-45
12572662-18	2003	The recent identification of other proteins of iron and copper metabolism, for example, copper ATPases and the membrane iron transporters DCT1/DMT1/Nramp2 and IREG1/MTP1/ferroportinl, are likely to fill crucial pathway gaps.	Iron	47-51	solute carrier family 11 member 2	Homo sapiens	138-142
12572662-18	2003	The recent identification of other proteins of iron and copper metabolism, for example, copper ATPases and the membrane iron transporters DCT1/DMT1/Nramp2 and IREG1/MTP1/ferroportinl, are likely to fill crucial pathway gaps.	Iron	47-51	solute carrier family 11 member 2	Homo sapiens	143-147
12572662-18	2003	The recent identification of other proteins of iron and copper metabolism, for example, copper ATPases and the membrane iron transporters DCT1/DMT1/Nramp2 and IREG1/MTP1/ferroportinl, are likely to fill crucial pathway gaps.	Iron	47-51	solute carrier family 11 member 2	Homo sapiens	148-154
12572662-18	2003	The recent identification of other proteins of iron and copper metabolism, for example, copper ATPases and the membrane iron transporters DCT1/DMT1/Nramp2 and IREG1/MTP1/ferroportinl, are likely to fill crucial pathway gaps.	Iron	47-51	solute carrier family 40 member 1	Homo sapiens	159-164
12572662-18	2003	The recent identification of other proteins of iron and copper metabolism, for example, copper ATPases and the membrane iron transporters DCT1/DMT1/Nramp2 and IREG1/MTP1/ferroportinl, are likely to fill crucial pathway gaps.	Iron	47-51	solute carrier family 40 member 1	Homo sapiens	165-169
12572663-16	2003	In rodent mutants, Fe and Mn appear more dependent on DMT1 than Cu and Zn.	Iron	19-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	54-58
12572666-6	2003	Heme oxygenase-1, an enzyme that catalyzes the conversion of heme to iron and biliverdin, is increased in Alzheimer disease suggesting increased heme turnover as a source of redox-active iron.	Iron	69-73	heme oxygenase 1	Homo sapiens	0-16
12406866-11	2003	These findings suggest that most of the iron deposited in perinuclear mitochondria of ring sideroblasts is present in the form of MtF and that this latter might be a specific marker of sideroblastic anemia.	Iron	40-44	ferritin mitochondrial	Homo sapiens	130-133
12595602-7	2003	Hepcidin has recently been identified as part of the innate immune response and is a key regulator of cellular iron egress.	Iron	111-115	hepcidin antimicrobial peptide	Homo sapiens	0-8
12595602-8	2003	Based on our findings in this patient group, we propose a central role for hepcidin in anemia of chronic disease, linking the inflammatory process with iron recycling and erythropoiesis.	Iron	152-156	hepcidin antimicrobial peptide	Homo sapiens	75-83
12598195-1	2003	This study is to establish optimal conditions for the minimization of iron sludge produced in Fenton oxidation processes by electro-regenerating Fe(2+) with constant potential (CPM) or constant current mode (CCM).	Iron	70-74	carboxypeptidase M	Homo sapiens	177-180
12606179-0	2003	Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.	Iron	102-106	hepcidin antimicrobial peptide	Homo sapiens	10-18
12606179-2	2003	However, results of some studies indicate a link between hepcidin, a liver-derived peptide, and intestinal iron absorption, suggesting that this molecule could play a part in hepatic iron overload.	Iron	107-111	hepcidin antimicrobial peptide	Homo sapiens	57-65
12606179-2	2003	However, results of some studies indicate a link between hepcidin, a liver-derived peptide, and intestinal iron absorption, suggesting that this molecule could play a part in hepatic iron overload.	Iron	183-187	hepcidin antimicrobial peptide	Homo sapiens	57-65
12606179-3	2003	To investigate this possible association, we studied the hepatic expression of the gene for hepcidin (HAMP) and a gene important in iron transport (IREG1) in patients with haemochromatosis, in normal controls, and in Hfe-knockout mice.	Iron	132-136	solute carrier family 40 member 1	Homo sapiens	148-153
12606179-9	2003	There was a significant correlation between hepatic iron concentration and expression of HAMP (r=0.59, p=0.02) and IREG1 (r=0.67, p=0.007) in untreated patients.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	89-93
12606179-9	2003	There was a significant correlation between hepatic iron concentration and expression of HAMP (r=0.59, p=0.02) and IREG1 (r=0.67, p=0.007) in untreated patients.	Iron	52-56	solute carrier family 40 member 1	Homo sapiens	115-120
12606179-10	2003	INTERPRETATION: Lack of HAMP upregulation in HFE-associated haemochromatosis despite significant hepatic iron loading indicates that HFE plays an important part in the regulation of hepcidin expression in response to iron overload.	Iron	217-221	hepcidin antimicrobial peptide	Homo sapiens	182-190
12606179-12	2003	Furthermore, the increase in hepatic IREG1 expression in haemochromatosis suggests that IREG1 could function to facilitate the removal of excess iron from the liver.	Iron	145-149	solute carrier family 40 member 1	Homo sapiens	37-42
12606179-12	2003	Furthermore, the increase in hepatic IREG1 expression in haemochromatosis suggests that IREG1 could function to facilitate the removal of excess iron from the liver.	Iron	145-149	solute carrier family 40 member 1	Homo sapiens	88-93
12553798-0	2003	Spectroscopic evidence for site specific chemistry at a unique iron site of the [4Fe-4S] cluster in ferredoxin:thioredoxin reductase.	Iron	63-67	peroxiredoxin 5	Homo sapiens	111-132
12626118-3	2003	A central component of the redox cascade is a novel enzyme, the ferredoxin:thioredoxin reductase, which is capable of reducing a disulfide bridge with the help of an iron-sulfur cluster.	Iron	166-170	peroxiredoxin 5	Homo sapiens	75-96
12504902-5	2003	Incubation of apoferritin with 1-10mM ALA produced dose-dependent decreases in tryptophan fluorescence (11-35% after 5h), and a partial depletion of protein thiols (18% after 24h) despite substantial removal of catalytic iron.	Iron	221-225	ferritin heavy chain 1	Homo sapiens	14-25
12504902-7	2003	The damage to apoferritin had no effect on ferroxidase activity, but produced a 61% decrease in iron uptake ability.	Iron	96-100	ferritin heavy chain 1	Homo sapiens	14-25
12938016-0	2003	Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J-type co-chaperone.	Iron	48-52	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	125-129
12946050-9	2003	Indeed MPTP treatment, which results in iron accumulation in SNCP, abolishes IRP2 with the concomitant increase in alpha-synuclein.	Iron	40-44	synuclein, alpha	Mus musculus	115-130
12946050-10	2003	Iron chelators such as R-apomorphine and EGCG, which protect against MPTP neurotoxicity, prevent the loss of IRP2 and the increase in alpha-synuclein.	Iron	0-4	synuclein, alpha	Mus musculus	134-149
12946050-12	2003	Since, iron has been shown to cause aggregation of alpha-synuclein to a neurotoxic agent.	Iron	7-11	synuclein, alpha	Mus musculus	51-66
12469120-1	2003	Animal models indicate that the antimicrobial peptide hepcidin (HAMP; OMIM 606464) is probably a key regulator of iron absorption in mammals.	Iron	114-118	hepcidin antimicrobial peptide	Homo sapiens	64-68
12964953-5	2003	HO-1 and its constitutively expressed isozyme, heme oxygenase-2, catalyze the rate-limiting step in the conversion of heme to its metabolites, bilirubin IXalpha, ferrous iron, and carbon monoxide (CO).	Iron	170-174	heme oxygenase 1	Homo sapiens	0-4
12480800-8	2002	Iron supplementation also significantly increased the mean serum copper concentration to 14.2 +/- 5.4 micro mol/L and, in subjects with serum ferritin concentrations &lt;/=12 micro g/L, the mean serum ceruloplasmin concentration.	Iron	0-4	ceruloplasmin	Homo sapiens	201-214
12480800-10	2002	Iron supplements improved indices of iron status and serum copper and ceruloplasmin concentrations.	Iron	0-4	ceruloplasmin	Homo sapiens	70-83
12480800-11	2002	Whether the diminished serum copper and ceruloplasmin concentrations and superoxide dismutase activity are associated with free radical damage to iron depleted cells requires further investigation.	Iron	146-150	ceruloplasmin	Homo sapiens	40-53
12475959-1	2002	Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral tissues.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	0-28
12475959-1	2002	Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral tissues.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	30-34
12475959-1	2002	Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral tissues.	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	0-28
12475959-1	2002	Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral tissues.	Iron	127-131	solute carrier family 11 member 2	Homo sapiens	30-34
12475959-11	2002	Our data indicate that the cell type-specific expression patterns and the distinct subcellular localizations of two DMT1 isoforms may be involved in the different iron acquisition steps from the subcellular membranes in various cell types.	Iron	163-167	solute carrier family 11 member 2	Homo sapiens	116-120
12215434-2	2002	Copper and iron levels both show marked increases with age and may adversely interact with the amyloid-beta (Abeta) peptide causing its aggregation and the production of neurotoxic hydrogen peroxide (H(2)O(2)), contributing to the pathogenesis of AD.	Iron	11-15	amyloid beta (A4) precursor protein	Mus musculus	109-114
12215434-4	2002	Here we demonstrate that overexpression of the carboxyl-terminal fragment of APP, containing Abeta, results in significantly reduced copper and iron levels in transgenic mouse brain, while overexpression of the APP in Tg2576 transgenic mice results in significantly reduced copper, but not iron, levels prior to the appearance of amyloid neuropathology and throughout the lifespan of the mouse.	Iron	144-148	amyloid beta (A4) precursor protein	Mus musculus	93-98
12547227-0	2002	The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption.	Iron	67-71	ceruloplasmin	Mus musculus	4-17
12547228-0	2002	Mitochondrial ferritin: a new player in iron metabolism.	Iron	40-44	ferritin mitochondrial	Homo sapiens	0-22
12547228-7	2002	The levels of MtF appear to correlate more with mitochondrial abundance than with iron metabolism.	Iron	82-86	ferritin mitochondrial	Homo sapiens	14-17
12547228-11	2002	In transfected HeLa cells added iron is incorporated as quickly into MtF as into cytosolic ferritin.	Iron	32-36	ferritin mitochondrial	Homo sapiens	69-72
12547228-12	2002	In addition, increased levels of MtF cause a redistribution of iron from cytosol to mitochondria and this effect is enhanced by iron chelation.	Iron	63-67	ferritin mitochondrial	Homo sapiens	33-36
12547228-12	2002	In addition, increased levels of MtF cause a redistribution of iron from cytosol to mitochondria and this effect is enhanced by iron chelation.	Iron	128-132	ferritin mitochondrial	Homo sapiens	33-36
12547228-13	2002	Thus high levels of MtF result in an iron deficient phenotype in cytosol with decreased expression of ferritin and increased expression of transferrin receptor.	Iron	37-41	ferritin mitochondrial	Homo sapiens	20-23
12547228-14	2002	This avidity for iron may explain why MtF levels are maintained at low levels in most normal cells.	Iron	17-21	ferritin mitochondrial	Homo sapiens	38-41
12547228-15	2002	The regulation of MtF expression and possible therapeutic applications of MtF in neurological disorders involving increased iron deposition are topics for future research.	Iron	124-128	ferritin mitochondrial	Homo sapiens	74-77
12547239-3	2002	Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far.	Iron	135-139	solute carrier family 40 member 1	Homo sapiens	18-22
12547239-4	2002	The effects of iron perturbations on DMT1 and FPN1 expression were investigated in CaCo2 cells and in primary tissue cultures of human duodenal biopsies by means of Northern Blot, Western Blot, RNA-bandshift and Nuclear Run off analysis.	Iron	15-19	solute carrier family 11 member 2	Homo sapiens	37-41
12547239-8	2002	Nuclear run-off analysis then demonstrated that the effects of iron and desferrioxamine on DMT1 and FPN1 mRNA expression are rather due to modulation of transcription of these genes.	Iron	63-67	solute carrier family 11 member 2	Homo sapiens	91-95
12547239-8	2002	Nuclear run-off analysis then demonstrated that the effects of iron and desferrioxamine on DMT1 and FPN1 mRNA expression are rather due to modulation of transcription of these genes.	Iron	63-67	solute carrier family 40 member 1	Homo sapiens	100-104
12547239-9	2002	Our results demonstrate that iron unidirectionally regulates the expression of the two ferrous ion transporters DMT1 and FPN1 by affecting their transcription.	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	112-116
12547239-9	2002	Our results demonstrate that iron unidirectionally regulates the expression of the two ferrous ion transporters DMT1 and FPN1 by affecting their transcription.	Iron	29-33	solute carrier family 40 member 1	Homo sapiens	121-125
12462520-0	2002	A possible link between hepcidin and regulation of dietary iron absorption.	Iron	59-63	hepcidin antimicrobial peptide	Homo sapiens	24-32
12462520-1	2002	The antimicrobial peptide hepcidin has been implicated in the regulation of iron homeostasis.	Iron	76-80	hepcidin antimicrobial peptide	Homo sapiens	26-34
12462520-2	2002	Hepcidin is theorized to be a key link between body iron stores and the appropriate modulation of dietary iron absorption.	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	0-8
12462520-2	2002	Hepcidin is theorized to be a key link between body iron stores and the appropriate modulation of dietary iron absorption.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	0-8
12138110-0	2002	The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.	Iron	108-112	hepcidin antimicrobial peptide	Homo sapiens	32-40
12223357-0	2002	The transcytosis of divalent metal transporter 1 and apo-transferrin during iron uptake in intestinal epithelium.	Iron	76-80	solute carrier family 11 member 2	Homo sapiens	20-48
12223357-3	2002	With the addition of iron to the apical surface, divalent metal transporter 1 (DMT1) on the brush-border membrane (BBM) undergoes endocytosis.	Iron	21-25	solute carrier family 11 member 2	Homo sapiens	49-77
12223357-3	2002	With the addition of iron to the apical surface, divalent metal transporter 1 (DMT1) on the brush-border membrane (BBM) undergoes endocytosis.	Iron	21-25	solute carrier family 11 member 2	Homo sapiens	79-83
12223357-4	2002	These findings suggest that in Caco-2 cells DMT1 and apo-transferrin may cooperate in iron transport through transcytosis.	Iron	86-90	solute carrier family 11 member 2	Homo sapiens	44-48
12223357-5	2002	To prove this hypothesis, we determined by confocal microscopy that, after addition of iron to the apical chamber, DMT1 from the BBM and Texas red apo-transferrin from the basal chamber colocalized in a perinuclear compartment.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	115-119
12398878-3	2002	HO-1 expression was correlated with increased tissue iron and/or ferritin expression and increased inflammatory/oxidant load as measured by myeloperoxidase expression.	Iron	53-57	heme oxygenase 1	Homo sapiens	0-4
12110671-1	2002	Iron is essential for growth, and impaired iron homoeostasis through a non-conserved mutation within murine Nramp1, also termed Slc11a1, contributes to susceptibility to infection.	Iron	0-4	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	108-114
12110671-2	2002	Nramp1 depletes the macrophage cytosol of iron, with effects on iron-regulated gene expression and iron-dependent processes.	Iron	42-46	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
12110671-2	2002	Nramp1 depletes the macrophage cytosol of iron, with effects on iron-regulated gene expression and iron-dependent processes.	Iron	64-68	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
12110671-2	2002	Nramp1 depletes the macrophage cytosol of iron, with effects on iron-regulated gene expression and iron-dependent processes.	Iron	64-68	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
12165435-6	2002	The dissociation constant of the distinct mAbs for hLF ranged from 0.5 to 18 nM, without differences in affinity for unsaturated or iron-saturated hLF, indicating that the conformational changes subject to incorporation of iron do not seem to affect the exposure and/or conformation of the antibody epitopes.	Iron	223-227	HLF transcription factor, PAR bZIP family member	Homo sapiens	51-54
12358761-4	2002	Importantly, for the aggregation of PHFtau to occur, iron in the oxidized state (III) is essential since iron in the reduced state (II) lacks such ability.	Iron	53-57	microtubule associated protein tau	Homo sapiens	36-42
12358761-4	2002	Importantly, for the aggregation of PHFtau to occur, iron in the oxidized state (III) is essential since iron in the reduced state (II) lacks such ability.	Iron	105-109	microtubule associated protein tau	Homo sapiens	36-42
12358761-7	2002	Further incubation of insoluble PHFtau aggregates isolated from AD brain with reducing agents produced liberation of solubilized PHFtau and iron (II), indicating that PHFtau in association with iron (III) constitutes the insoluble pool of PHFtau.	Iron	140-144	microtubule associated protein tau	Homo sapiens	32-38
12358761-7	2002	Further incubation of insoluble PHFtau aggregates isolated from AD brain with reducing agents produced liberation of solubilized PHFtau and iron (II), indicating that PHFtau in association with iron (III) constitutes the insoluble pool of PHFtau.	Iron	194-198	microtubule associated protein tau	Homo sapiens	32-38
12029093-3	2002	We here show that ceruloplasmin (Cp), an acute phase reactant with important functions in iron homeostasis, is subject to a unique dual regulation by insulin.	Iron	90-94	ceruloplasmin	Homo sapiens	18-31
12230869-1	2002	Heme oxygenase-1 (HO-1) is an inducible enzyme that degrades heme to carbon monoxide, iron ions, and biliverdin.	Iron	86-90	heme oxygenase 1	Homo sapiens	0-16
12230869-1	2002	Heme oxygenase-1 (HO-1) is an inducible enzyme that degrades heme to carbon monoxide, iron ions, and biliverdin.	Iron	86-90	heme oxygenase 1	Homo sapiens	18-22
12230871-4	2002	HO-1 cleaves the porphyrin macrocycle of heme at the expense of molecular oxygen to release a linear tetrapyrrole biliverdin, carbon monoxide, and ferrous iron; biliverdin is rapidly reduced to bilirubin.	Iron	155-159	heme oxygenase 1	Homo sapiens	0-4
12196176-2	2002	Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1).	Iron	89-93	solute carrier family 11 member 2	Homo sapiens	182-186
12196176-2	2002	Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1).	Iron	89-93	solute carrier family 11 member 2	Homo sapiens	188-217
12091366-7	2002	We propose that this mutation disrupts the function of the ferroportin1 protein, leading to impaired iron homeostasis and iron overload.	Iron	101-105	solute carrier family 40 member 1	Homo sapiens	59-71
12091367-0	2002	Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).	Iron	39-43	solute carrier family 40 member 1	Homo sapiens	99-112
12091367-0	2002	Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).	Iron	39-43	solute carrier family 40 member 1	Homo sapiens	119-126
11980894-0	2002	Activation of caspase pathways during iron chelator-mediated apoptosis.	Iron	38-42	caspase 9	Homo sapiens	14-21
11980894-3	2002	To determine the mechanism of cell death induced by iron chelators, we assessed the time course and pathways of caspase activation during apoptosis induced by iron chelators.	Iron	52-56	caspase 9	Homo sapiens	112-119
11980894-3	2002	To determine the mechanism of cell death induced by iron chelators, we assessed the time course and pathways of caspase activation during apoptosis induced by iron chelators.	Iron	159-163	caspase 9	Homo sapiens	112-119
11980894-9	2002	Caspase activation was not observed in cells treated with N-methyl tachpyridine, an N-alkylated derivative of tachpyridine which lacks an ability to react with iron.	Iron	160-164	caspase 9	Homo sapiens	0-7
12128190-1	2002	The iron ligand, Met80, of yeast iso-1-cytochrome c has been mutated to residues that are unable to bind to the iron.	Iron	4-8	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	33-38
12128190-1	2002	The iron ligand, Met80, of yeast iso-1-cytochrome c has been mutated to residues that are unable to bind to the iron.	Iron	112-116	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	33-38
12006577-0	2002	Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain.	Iron	83-87	Fe(2+) transporter	Saccharomyces cerevisiae S288C	53-57
12006577-2	2002	We show here that MRS4 is co-regulated with the iron regulon genes, and up-regulated in a strain deficient for Yfh1p, the yeast homologue of human frataxin.	Iron	48-52	Fe(2+) transporter	Saccharomyces cerevisiae S288C	18-22
12006577-6	2002	Conversely, a deltaYFH1 strain overexpressing MRS4 has an increased mitochondrial iron content and no mitochondrial genome.	Iron	82-86	Fe(2+) transporter	Saccharomyces cerevisiae S288C	46-50
12006577-7	2002	Therefore, MRS4 is required for mitochondrial iron accumulation in deltaYFH1 cells.	Iron	46-50	Fe(2+) transporter	Saccharomyces cerevisiae S288C	11-15
12006577-11	2002	The function of MRS4 in iron import into mitochondria is discussed.	Iron	24-28	Fe(2+) transporter	Saccharomyces cerevisiae S288C	16-20
12070039-4	2002	Measurements of TfR mRNA half-life indicated that hyperexpression in SCF erythroblasts was due to a massive stabilization of transcripts even in the presence of high iron levels.	Iron	166-170	KIT ligand	Gallus gallus	69-72
12070039-5	2002	Changes in mRNA binding activity of iron regulatory protein 1 (IRP1), the primary regulator of TfR mRNA stability in these cells, correlated well with TfR mRNA expression; IRP1 activity in HD3E22 cells and other nonerythroid cell types tested was iron dependent, whereas IRP1 activity in primary SCF erythroblasts could not be modulated by iron administration.	Iron	36-40	KIT ligand	Gallus gallus	296-299
12070039-7	2002	In SCF erythroblasts high amounts of TfR were detected on the plasma membrane, but a large fraction was also located in early and late endosomal compartments, potentially concealing temporary iron stores from the IRP regulatory system.	Iron	192-196	KIT ligand	Gallus gallus	3-6
12117267-3	2002	Here, we report the effect of Fe overload in mice lacking cellular glutathione peroxidase (GPX1 knockout [KO] mice), the selenoenzyme thought to account for much of the antioxidant action of Se.	Iron	30-32	glutathione peroxidase 1	Mus musculus	58-89
12117267-3	2002	Here, we report the effect of Fe overload in mice lacking cellular glutathione peroxidase (GPX1 knockout [KO] mice), the selenoenzyme thought to account for much of the antioxidant action of Se.	Iron	30-32	glutathione peroxidase 1	Mus musculus	91-95
12101093-5	2002	We used affinity cleavage by the EDTA.Fe-modified double-stranded RNA-binding domain (dsRBD) of PKR to show that stem-loop IV (nucleotides 87-123) of EBER1 makes specific contacts with the dsRBD.	Iron	38-40	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	96-99
11953424-2	2002	The mature recombinant MtF has a ferroxidase center and binds iron in vitro similarly to H-ferritin.	Iron	62-66	ferritin mitochondrial	Homo sapiens	23-26
11953424-6	2002	The wild type MtF and the mitochondrially targeted H-ferritin both incorporated the (55)Fe label in vivo.	Iron	88-90	ferritin mitochondrial	Homo sapiens	14-17
11953424-8	2002	Increased levels of MtF both in transient and in stable transfectants resulted in a greater retention of iron as MtF in mitochondria, a decrease in the levels of cytosolic ferritins, and up-regulation of transferrin receptor.	Iron	105-109	ferritin mitochondrial	Homo sapiens	20-23
11953424-8	2002	Increased levels of MtF both in transient and in stable transfectants resulted in a greater retention of iron as MtF in mitochondria, a decrease in the levels of cytosolic ferritins, and up-regulation of transferrin receptor.	Iron	105-109	ferritin mitochondrial	Homo sapiens	113-116
11953424-10	2002	Our results indicate that exogenous iron is as available to mitochondrial ferritin as it is to cytosolic ferritins and that the level of MtF expression may have profound consequences for cellular iron homeostasis.	Iron	196-200	ferritin mitochondrial	Homo sapiens	137-140
12060140-10	2002	Our results clarify the natural history of the disease and are compatible with the hypothesis that the HFE2 gene has greater influence on iron absorption than other haemochromatosis-associated genes.	Iron	138-142	hemojuvelin BMP co-receptor	Homo sapiens	103-107
12243984-6	2002	The study of X-linked sideroblastic anaemia has shown that the entry of iron into the mitochondria is poorly controlled and able to occur when protoporphyrin production is reduced, as is seen with the ALA-S2 mutations, or when it is increased as has been seen with ABC7 transporter mutations.	Iron	72-76	ATP binding cassette subfamily B member 7	Homo sapiens	265-269
23345766-1	2002	Myoglobin, a small globular heme protein that binds gaseous ligands such asO(2), CO and NO reversibly at the heme iron, provides an excellent modelsystem for studying structural and dynamic aspects of protein reactions.	Iron	114-118	myoglobin	Homo sapiens	0-9
11984516-9	2002	CONCLUSIONS: Our data support the role of the transferrin receptor 2 gene in hemochromatosis type 3 as well as its critical involvement in the maintenance of iron homeostasis in humans.	Iron	158-162	transferrin receptor 2	Homo sapiens	46-68
12010660-10	2002	The presence of traces of copper in the lysosomes and in the cytosol may be correlated with the stronger hypothesis of links in the metabolism of the two elements (iron and copper), as ceruloplasmin is a ferroxidase copper-dependent protein.	Iron	164-168	ceruloplasmin	Homo sapiens	185-198
11981562-4	2002	Natural hLF from human milk and rhLF had identical iron-binding and -release properties.	Iron	51-55	HLF transcription factor, PAR bZIP family member	Homo sapiens	8-11
12018267-1	2002	Lactoferrin (Lf), a protein found in human and bovine milk, tears, blood, and other secretory fluids, has been used to prevent infection from potential microbial pathogens by its ability to bind with iron (Fe3+).	Iron	200-204	lactotransferrin	Bos taurus	0-11
11987979-0	2002	Fas-ligand--iron fist or Achilles" heel?	Iron	12-16	Fas ligand	Homo sapiens	0-10
11925126-8	2002	TUNEL assay, flow cytometry with annexin-V-fluorescein, and morphological analysis indicated that iron chelation also induced a time- and dose-dependent apoptosis of both cell lines.	Iron	98-102	annexin A5	Homo sapiens	33-42
11925462-0	2002	Iron treatment downregulates DMT1 and IREG1 mRNA expression in Caco-2 cells.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	29-33
11925462-0	2002	Iron treatment downregulates DMT1 and IREG1 mRNA expression in Caco-2 cells.	Iron	0-4	solute carrier family 40 member 1	Homo sapiens	38-43
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	46-50	solute carrier family 11 member 2	Homo sapiens	99-103
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	46-50	solute carrier family 11 member 2	Homo sapiens	104-108
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	46-50	solute carrier family 11 member 2	Homo sapiens	109-115
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	46-50	solute carrier family 40 member 1	Homo sapiens	148-153
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	46-50	solute carrier family 40 member 1	Homo sapiens	154-166
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	46-50	solute carrier family 40 member 1	Homo sapiens	167-171
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	99-103
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	104-108
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	109-115
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	148-153
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	154-166
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	99-103
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	104-108
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	109-115
11925462-3	2002	Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation.	Iron	75-79	solute carrier family 40 member 1	Homo sapiens	148-153
11952985-0	2002	Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units.	Iron	32-36	S-antigen visual arrestin	Homo sapiens	56-59
11756457-5	2002	In addition, the two iron chelators desferrioxamine (1 mm) and o-phenanthroline (0.2 mm) significantly inhibited hERG1 outward K(+) currents and prevented hERG1 inhibition induced by the ROS-scavenging enzyme catalase (1000 units/ml).	Iron	21-25	potassium voltage-gated channel subfamily H member 2	Homo sapiens	113-118
11756457-5	2002	In addition, the two iron chelators desferrioxamine (1 mm) and o-phenanthroline (0.2 mm) significantly inhibited hERG1 outward K(+) currents and prevented hERG1 inhibition induced by the ROS-scavenging enzyme catalase (1000 units/ml).	Iron	21-25	potassium voltage-gated channel subfamily H member 2	Homo sapiens	155-160
11756457-6	2002	Finally, the hERG1-inhibitory effect exerted by the iron chelators was prevented by the hERG1 H578D/H587Y double mutation.	Iron	52-56	potassium voltage-gated channel subfamily H member 2	Homo sapiens	13-18
11756457-6	2002	Finally, the hERG1-inhibitory effect exerted by the iron chelators was prevented by the hERG1 H578D/H587Y double mutation.	Iron	52-56	potassium voltage-gated channel subfamily H member 2	Homo sapiens	88-93
11958952-9	2002	Inhibition of cysteylation of membrane GBP by O(-)(2) was still observed after iron chelation by desferrioxamine, albeit diminished, and was not altered by the presence of catalase.	Iron	79-83	transmembrane protein 132A	Homo sapiens	39-42
11842003-6	2002	These results suggest that DMT1, Fpn1, and Heph are involved in the iron uptake process modulated by copper status.	Iron	68-72	solute carrier family 11 member 2	Homo sapiens	27-31
11842003-6	2002	These results suggest that DMT1, Fpn1, and Heph are involved in the iron uptake process modulated by copper status.	Iron	68-72	solute carrier family 40 member 1	Homo sapiens	33-37
11842004-9	2002	Since paraferritin functions to reduce newly transported ferric iron to ferrous iron and DMT-1 can transport ferrous iron, these findings suggest a role for DMT-1 in conveyance of iron from paraferritin to ferrochelatase, the enzyme utilizing ferrous iron for the synthesis of heme in the mitochondrion.	Iron	80-84	solute carrier family 11 member 2	Homo sapiens	157-162
11842004-9	2002	Since paraferritin functions to reduce newly transported ferric iron to ferrous iron and DMT-1 can transport ferrous iron, these findings suggest a role for DMT-1 in conveyance of iron from paraferritin to ferrochelatase, the enzyme utilizing ferrous iron for the synthesis of heme in the mitochondrion.	Iron	80-84	solute carrier family 11 member 2	Homo sapiens	157-162
11804801-8	2002	The amount of LCH protein corresponds well with the message levels in control animals, while in iron-fed animals LCH does not increase proportionally with the message levels.	Iron	96-100	Ferritin 2 light chain homologue	Drosophila melanogaster	113-116
11880554-1	2002	Evidence supports a role for ceruloplasmin (ferroxidase I) in the release of iron to the blood from mammalian cells.	Iron	77-81	ceruloplasmin	Homo sapiens	29-42
11893478-0	2002	Effects of copper and ceruloplasmin on iron transport in the Caco 2 cell intestinal model.	Iron	39-43	ceruloplasmin	Homo sapiens	22-35
11893478-1	2002	Previous studies have implicated copper proteins, including ceruloplasmin, in intestinal iron transport.	Iron	89-93	ceruloplasmin	Homo sapiens	60-73
11893478-2	2002	Polarized Caco2 cells with tight junctions were used to examine the possibilities that (a) ceruloplasmin promotes iron absorption by enhancing release at the basolateral cell surface and (b) copper deficiency reduces intestinal iron transport.	Iron	114-118	ceruloplasmin	Homo sapiens	91-104
11952908-3	2002	A previous study showed that, in the Gram-positive human pathogen Staphylococcus aureus, a cell surface-associated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) enzyme (Gap, or Tpn) is capable of binding human transferrin, representing a potential means by which this bacterium is able to access iron in vivo.	Iron	299-303	AT695_RS09095	Staphylococcus aureus	115-155
11952908-3	2002	A previous study showed that, in the Gram-positive human pathogen Staphylococcus aureus, a cell surface-associated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) enzyme (Gap, or Tpn) is capable of binding human transferrin, representing a potential means by which this bacterium is able to access iron in vivo.	Iron	299-303	AT695_RS09095	Staphylococcus aureus	157-162
11833084-9	2002	CONCLUSION: While mother-rats were exposed to manganese, the metabolisms of Mn Zn and Fe of new-born rats in the livers were influenced and were situated in a stress status, thus HSP70 syntheses is induced in the brains and livers of new-born rats, but the mechanism of this effect in the developmental toxicity of Mn remains to be further studied.	Iron	86-88	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	179-184
11738613-3	2002	The treatment of L-1210 and Molt-4 cells with HPH-Pep resulted in a significant breakdown of the survival rate at 44 degrees C. The cell death induced by HPH-Pep under hyperthermic condition seemed to involve iron and peroxide.	Iron	209-213	progestagen associated endometrial protein	Homo sapiens	50-53
11738613-3	2002	The treatment of L-1210 and Molt-4 cells with HPH-Pep resulted in a significant breakdown of the survival rate at 44 degrees C. The cell death induced by HPH-Pep under hyperthermic condition seemed to involve iron and peroxide.	Iron	209-213	progestagen associated endometrial protein	Homo sapiens	158-161
12139399-0	2002	The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine.	Iron	37-41	solute carrier family 40 member 1	Homo sapiens	77-82
12139399-0	2002	The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine.	Iron	116-120	solute carrier family 40 member 1	Homo sapiens	77-82
12139399-2	2002	Dietary iron enters the intestinal epithelium via the brush-border transporter DMT1 and exits through the basolateral membranes.	Iron	8-12	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
12139399-3	2002	The basolateral transfer of iron requires two components: a copper-containing iron oxidase known as hephaestin and a membrane transport protein IREG1.	Iron	28-32	solute carrier family 40 member 1	Homo sapiens	144-149
12139399-6	2002	This, in turn, modulates the intracellular iron content of mature epithelial cells, which ultimately determines the activity of the brush-border transporter DMT1.	Iron	43-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	157-161
11746175-5	2002	A wide range of chelator types bind iron(III) and of these, hexa-, tri-, and bidentate are capable of providing iron(III) with the favoured octahedral environment.	Iron	36-40	hexosaminidase subunit alpha	Homo sapiens	60-64
11747454-1	2001	Lactoferrin (Lf), a major iron-binding protein in human milk, has been suggested to have multiple biological roles such as facilitating iron absorption, modulating the immune system, embryonic development, and cell proliferation.	Iron	26-30	intelectin 1	Homo sapiens	13-15
11747454-1	2001	Lactoferrin (Lf), a major iron-binding protein in human milk, has been suggested to have multiple biological roles such as facilitating iron absorption, modulating the immune system, embryonic development, and cell proliferation.	Iron	136-140	intelectin 1	Homo sapiens	13-15
11747454-2	2001	Our previous binding studies suggested the presence of a specific receptor for Lf (LfR) in the small intestine of newborn infants, which may facilitate iron absorption.	Iron	152-156	intelectin 1	Homo sapiens	79-81
11747454-2	2001	Our previous binding studies suggested the presence of a specific receptor for Lf (LfR) in the small intestine of newborn infants, which may facilitate iron absorption.	Iron	152-156	intelectin 1	Homo sapiens	83-86
11747454-3	2001	We here report the cloning and the functional expression of the human intestinal LfR and the evidence of its involvement in iron metabolism.	Iron	124-128	intelectin 1	Homo sapiens	81-84
11741608-1	2001	The first step in intestinal iron absorption is mediated by the H(+)-coupled Fe(2+) transporter called divalent cation transporter 1/divalent metal ion transporter 1 (DCT1/DMT1) (also known as natural resistance-associated macrophage protein 2).	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	103-165
11741608-1	2001	The first step in intestinal iron absorption is mediated by the H(+)-coupled Fe(2+) transporter called divalent cation transporter 1/divalent metal ion transporter 1 (DCT1/DMT1) (also known as natural resistance-associated macrophage protein 2).	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	167-171
11741608-1	2001	The first step in intestinal iron absorption is mediated by the H(+)-coupled Fe(2+) transporter called divalent cation transporter 1/divalent metal ion transporter 1 (DCT1/DMT1) (also known as natural resistance-associated macrophage protein 2).	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	172-176
11741608-1	2001	The first step in intestinal iron absorption is mediated by the H(+)-coupled Fe(2+) transporter called divalent cation transporter 1/divalent metal ion transporter 1 (DCT1/DMT1) (also known as natural resistance-associated macrophage protein 2).	Iron	29-33	solute carrier family 11 member 2	Homo sapiens	193-243
11741608-2	2001	DCT1/DMT1 mRNA levels in the duodenum strongly increase in response to iron depletion.	Iron	71-75	solute carrier family 11 member 2	Homo sapiens	0-4
11741608-2	2001	DCT1/DMT1 mRNA levels in the duodenum strongly increase in response to iron depletion.	Iron	71-75	solute carrier family 11 member 2	Homo sapiens	5-9
11741608-3	2001	To study the mechanism of iron-dependent DCT1/DMT1 mRNA regulation, we investigated the endogenous expression of DCT1/DMT1 mRNA in various cell types.	Iron	26-30	solute carrier family 11 member 2	Homo sapiens	41-45
11741608-3	2001	To study the mechanism of iron-dependent DCT1/DMT1 mRNA regulation, we investigated the endogenous expression of DCT1/DMT1 mRNA in various cell types.	Iron	26-30	solute carrier family 11 member 2	Homo sapiens	46-50
11741608-3	2001	To study the mechanism of iron-dependent DCT1/DMT1 mRNA regulation, we investigated the endogenous expression of DCT1/DMT1 mRNA in various cell types.	Iron	26-30	solute carrier family 11 member 2	Homo sapiens	113-117
11741608-3	2001	To study the mechanism of iron-dependent DCT1/DMT1 mRNA regulation, we investigated the endogenous expression of DCT1/DMT1 mRNA in various cell types.	Iron	26-30	solute carrier family 11 member 2	Homo sapiens	118-122
11741608-4	2001	We found that only the iron responsive element (IRE)-containing form, which corresponds to one of two splice forms of DCT1/DMT1, is responsive to iron treatment and this responsiveness was cell type specific.	Iron	23-27	solute carrier family 11 member 2	Homo sapiens	118-122
11741608-4	2001	We found that only the iron responsive element (IRE)-containing form, which corresponds to one of two splice forms of DCT1/DMT1, is responsive to iron treatment and this responsiveness was cell type specific.	Iron	23-27	solute carrier family 11 member 2	Homo sapiens	123-127
11741608-4	2001	We found that only the iron responsive element (IRE)-containing form, which corresponds to one of two splice forms of DCT1/DMT1, is responsive to iron treatment and this responsiveness was cell type specific.	Iron	146-150	solute carrier family 11 member 2	Homo sapiens	118-122
11741608-4	2001	We found that only the iron responsive element (IRE)-containing form, which corresponds to one of two splice forms of DCT1/DMT1, is responsive to iron treatment and this responsiveness was cell type specific.	Iron	146-150	solute carrier family 11 member 2	Homo sapiens	123-127
11741608-7	2001	We propose that regulation of DCT1/DMT1 mRNA by iron involves post-transcriptional regulation through the binding of IRP1 to the transporter"s IRE, as well as other as yet unknown factors.	Iron	48-52	solute carrier family 11 member 2	Homo sapiens	30-34
11741608-7	2001	We propose that regulation of DCT1/DMT1 mRNA by iron involves post-transcriptional regulation through the binding of IRP1 to the transporter"s IRE, as well as other as yet unknown factors.	Iron	48-52	solute carrier family 11 member 2	Homo sapiens	35-39
11733371-4	2001	Distinct alpha-SYN species were detected in the detergent-insoluble fractions from brains of patients with PD, dementia with LBs, and neurodegeneration with brain iron accumulation type 1 (formerly known as Hallervorden-Spatz disease).	Iron	163-167	synuclein alpha	Homo sapiens	9-18
11592943-1	2001	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing iron, carbon monoxide, and biliverdin.	Iron	88-92	heme oxygenase 1	Homo sapiens	0-16
11592943-1	2001	Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing iron, carbon monoxide, and biliverdin.	Iron	88-92	heme oxygenase 1	Homo sapiens	18-22
11668058-1	2001	Heme oxygenase-1 (HO-1) catalyzes the enzymatic degradation of heme to carbon monoxide, bilirubin, and iron.	Iron	103-107	heme oxygenase 1	Homo sapiens	0-16
11668058-1	2001	Heme oxygenase-1 (HO-1) catalyzes the enzymatic degradation of heme to carbon monoxide, bilirubin, and iron.	Iron	103-107	heme oxygenase 1	Homo sapiens	18-22
11684086-3	2001	Several studies have shown that increasing dietary iron downregulates DMT1.	Iron	51-55	solute carrier family 11 member 2	Homo sapiens	70-74
11684086-5	2001	Transepithelial flux of iron was also increased and was associated with a rise in IREG1 mRNA expression.	Iron	24-28	solute carrier family 40 member 1	Homo sapiens	82-87
11595384-7	2001	The addition of ceruloplasmin to the iron loading assay eliminated the detection of the DMPO-*OH adduct observed during loading using the ferroxidase activity of ferritin.	Iron	37-41	ceruloplasmin	Homo sapiens	16-29
11595384-8	2001	The elimination of the DMPO-*OH adduct was determined to be due to the ability of ceruloplasmin to completely reduce oxygen to water during the oxidation of the ferrous iron.	Iron	169-173	ceruloplasmin	Homo sapiens	82-95
11595385-0	2001	The consequences of hydroxyl radical formation on the stoichiometry and kinetics of ferrous iron oxidation by human apoferritin.	Iron	84-96	ferritin heavy chain 1	Homo sapiens	116-127
11687297-1	2001	Although the antiviral activity of lactoferrin is one of the major biological functions of this iron binding protein, the mechanism of action is still under debate.	Iron	96-100	lactotransferrin	Bos taurus	35-46
11677250-2	2001	Recent transcranial ultrasound findings and the observation of the ability of iron to induce aggregation and toxicity of alpha-synuclein have reinforced the critical role of iron in the pathogenesis of nigrostriatal injury.	Iron	78-82	synuclein alpha	Homo sapiens	121-136
11677250-2	2001	Recent transcranial ultrasound findings and the observation of the ability of iron to induce aggregation and toxicity of alpha-synuclein have reinforced the critical role of iron in the pathogenesis of nigrostriatal injury.	Iron	174-178	synuclein alpha	Homo sapiens	121-136
11677250-5	2001	Moreover we outline that the interaction of iron with other molecules, especially alpha-synuclein, may contribute to the process of neurodegeneration.	Iron	44-48	synuclein alpha	Homo sapiens	82-97
11533233-1	2001	Ceruloplasmin (Cp) is a glycoprotein secreted by the liver and monocytic cells and probably plays roles in inflammation and iron metabolism.	Iron	124-128	ceruloplasmin	Homo sapiens	0-13
11562226-2	2001	For norbornene (NBN), the Fe(+)-catalyzed retro reaction is also calculated to be stepwise with an activation barrier of 24.9 kcal/mol, which is 8.5 kcal/mol lower than the uncatalyzed stepwise reaction but 3.8 kcal/mol higher than the concerted reaction.	Iron	26-31	nibrin	Homo sapiens	16-19
11571246-3	2001	METHODS AND RESULTS: Infection of rat aortic smooth muscle cells with adenovirus carrying the human HO-1 gene (Adv-HO-1) resulted in a high-level expression of HO-1 protein, which effectively reduced the hemin-induced iron overload in these cells.	Iron	218-222	heme oxygenase 1	Homo sapiens	100-104
11571246-3	2001	METHODS AND RESULTS: Infection of rat aortic smooth muscle cells with adenovirus carrying the human HO-1 gene (Adv-HO-1) resulted in a high-level expression of HO-1 protein, which effectively reduced the hemin-induced iron overload in these cells.	Iron	218-222	heme oxygenase 1	Homo sapiens	115-119
11575788-4	2001	The HPLC-ICPMS results for the iron speciation analysis of a raw beef steak, used as an analytical quality control (AQC) sample, showed that the main iron biomolecule present was the heme iron-containing protein myoglobin.	Iron	31-35	myoglobin	Homo sapiens	212-221
11535048-2	2001	A role for the hormone gastrin in iron uptake as a chelator of ferric ions in the gastric lumen has been proposed previously [Baldwin, G. S. (1992) Med.	Iron	34-38	gastrin	Homo sapiens	23-30
11535048-6	2001	Titration of glycine-extended gastrin(17) with ferric ions under stoichiometric conditions indicated that the stoichiometry of binding was 2.00 +/- 0.28 mol of Fe(3+)/mol of peptide.	Iron	160-162	gastrin	Homo sapiens	30-37
11546828-5	2001	We have moreover carried out a molecular analysis of candidate genes (beta(2)-microglobulin, HFE, and haem oxygenases 1 and 2) implicated in iron metabolism.	Iron	141-145	beta-2-microglobulin	Homo sapiens	70-91
11579132-6	2001	The presence of the iron chelators phenanthroline or deferoxamine (DFO), which previously has been shown to protect oligodendrocytes from oxidative stress-induced onset of apoptosis, caused a marked stimulation of HSP32 without affecting HSP70.	Iron	20-24	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	238-243
11532994-0	2001	Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?	Iron	79-83	dopamine beta-hydroxylase	Homo sapiens	21-46
11497826-1	2001	The nuclear quadrupole moment (NQM) of the Ipi = 3/2(-) excited nuclear state of 57Fe at 14.41 keV, important in Mossbauer spectroscopy, is determined from the large-scale nuclear shell-model calculations for 54Fe, 57Fe, and also from the electronic ab initio and density functional theory calculations including solid state and electron correlation effects for the molecules Fe(CO)(5) and Fe(C5H5)(2).	Iron	376-379	WD repeat domain 18	Homo sapiens	43-50
11493598-3	2001	Furthermore, Erv1p was found to be important for cellular iron homeostasis.	Iron	58-62	growth factor, augmenter of liver regeneration	Homo sapiens	13-18
11583400-6	2001	This study hints that hLf might participate in recovery from AT in several ways, e.g. by binding to the S. pyogenes pathogens, in addition to its well-known virtue of iron-binding capacity.	Iron	167-171	HLF transcription factor, PAR bZIP family member	Homo sapiens	22-25
11415455-5	2001	Ferritin is a 24 subunit protein composed of two subunit types, termed H and L. The ferritin H subunit has a potent ferroxidase activity that catalyses the oxidation of ferrous iron, whereas ferritin L plays a role in iron nucleation and protein stability.	Iron	177-181	ferritin heavy chain 1	Homo sapiens	84-102
11415455-5	2001	Ferritin is a 24 subunit protein composed of two subunit types, termed H and L. The ferritin H subunit has a potent ferroxidase activity that catalyses the oxidation of ferrous iron, whereas ferritin L plays a role in iron nucleation and protein stability.	Iron	218-222	ferritin heavy chain 1	Homo sapiens	84-102
11448591-4	2001	We examined the changes in plasma leptin levels in relation to expected improvement in appetite with iron treatment in children with iron deficiency.	Iron	101-105	leptin	Homo sapiens	34-40
11519132-1	2001	We report a human IgG4-lambda type M-protein that reacts with reagents of albumin, direct bilirubin and iron.	Iron	104-108	myomesin 2	Homo sapiens	35-44
11278996-7	2001	This indicates that cSHMT expression is increased by elevated HCF concentrations, independent of increased iron availability, suggesting that cSHMT expression may respond to HCF-induced chelation of the regulatory iron pool.	Iron	214-218	serine hydroxymethyltransferase 1	Homo sapiens	20-25
11278996-7	2001	This indicates that cSHMT expression is increased by elevated HCF concentrations, independent of increased iron availability, suggesting that cSHMT expression may respond to HCF-induced chelation of the regulatory iron pool.	Iron	214-218	serine hydroxymethyltransferase 1	Homo sapiens	142-147
11506893-0	2001	Ceruloplasmin enhances DNA damage induced by cysteine/iron in vitro.	Iron	54-58	ceruloplasmin	Homo sapiens	0-13
12214055-3	2001	Our studies have demonstrated that the level of the iron transport protein, p97, is increased in the serum of AD patients but not in various control groups.	Iron	52-56	melanotransferrin	Homo sapiens	76-79
12214055-6	2001	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	62-65
12214055-6	2001	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	148-151
11352890-5	2001	Increased release of AA in iron-overloaded NRVMs was reduced by the diacylglycerol lipase inhibitor RHC80267 but was largely insensitive to inhibitors of phospholipases A(2) and C. Iron-overloaded cardiomyocytes also displayed increased production of eicosanoids and induction of cyclooxygenase-2 after stimulation with interleukin-1alpha.	Iron	27-31	interleukin 1 alpha	Homo sapiens	320-338
11342657-6	2001	Similar to PDTC, the heme biosynthesis inhibitor succinylacetone (SA) and the iron-chelator pyridoxal isonicotinoyl hydrazone inhibited cellular IDO activity without affecting protein expression, whereas addition of hemin or the heme precursor delta-aminolevulinic acid increased IDO activity.	Iron	78-82	indoleamine 2,3-dioxygenase 1	Homo sapiens	145-148
11339250-7	2001	Mice treated with iron-free LF, 20% iron-saturated LF, MFGM or defatted MFGM showed 30%, 10%, 20% or 20% healing rates, respectively, when compared with the H. pylori-infected control.	Iron	18-22	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	55-59
11336783-4	2001	Monolayers of thioglycollate-induced mouse peritoneal macrophages with cell surface fibronectin recognized autologous erythrocytes oxidized with an iron catalyst ADP/Fe(3+).	Iron	148-152	fibronectin 1	Mus musculus	84-95
11336783-4	2001	Monolayers of thioglycollate-induced mouse peritoneal macrophages with cell surface fibronectin recognized autologous erythrocytes oxidized with an iron catalyst ADP/Fe(3+).	Iron	166-168	fibronectin 1	Mus musculus	84-95
11396784-6	2001	When dietary copper was 2.0 mg/kg of diet, high iron decreased (p&lt;0.008) cardiac and hepatic copper, plasma copper and ceruloplasmin, and increased (p&lt;0.02) cardiac weight, hepatic iron and plasma cholesterol.	Iron	48-52	ceruloplasmin	Homo sapiens	122-135
11354828-2	2001	Nramp1 functions as a proton/divalent cation antiporter in the membranes of late endosomes/lysosomes, regulating cytoplasmic iron levels in macrophages.	Iron	125-129	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
11162121-2	2001	After photodissociating a ligand from the heme iron of unfolded horse cytochrome c, we use transient optical absorption spectroscopy to measure the time scale of the diffusive motions that bring the heme, located at His18, into contact with its native ligand, Met80.	Iron	47-51	cytochrome c, somatic	Equus caballus	70-82
15992166-4	2001	PDF represents a novel class of mononuclear iron protein, utilising an Fe(2+) ion to catalyse the hydrolysis of an amide bond.	Iron	44-48	peptide deformylase, mitochondrial	Homo sapiens	0-3
11207374-7	2001	Recent identification and characterization of the hemochromatosis protein HFE, the iron importer Nramp2, the iron exporter ferroportin1, and the second transferrin-binding and -transport protein transferrin receptor 2, have demonstrated their important roles in maintaining body"s iron homeostasis.	Iron	83-87	solute carrier family 11 member 2	Homo sapiens	97-103
11207374-7	2001	Recent identification and characterization of the hemochromatosis protein HFE, the iron importer Nramp2, the iron exporter ferroportin1, and the second transferrin-binding and -transport protein transferrin receptor 2, have demonstrated their important roles in maintaining body"s iron homeostasis.	Iron	109-113	solute carrier family 40 member 1	Homo sapiens	123-135
11124838-5	2001	The opposite effects of iron and zinc metal ions on binding suggest that the oxidation of phospholipids also affects apo H-HBsAg interaction.	Iron	24-28	apolipoprotein H	Homo sapiens	117-122
27420126-2	2001	These include two molecules involved in brush border iron uptake, the ferric reductase DcytB and the iron transporter DMT1, and two mediating iron transfer to the body, the iron transporter Ireg1 and the ferroxidase hephaestin (Hp).	Iron	101-105	doublesex and mab-3 related transcription factor 1	Homo sapiens	118-122
27420126-4	2001	Evidence suggests that the block to absorption that follows a priming dose of iron is the result of elevated intracellular iron levels decreasing the expression of the brush border iron transporter DMT1.	Iron	78-82	doublesex and mab-3 related transcription factor 1	Homo sapiens	198-202
27420126-4	2001	Evidence suggests that the block to absorption that follows a priming dose of iron is the result of elevated intracellular iron levels decreasing the expression of the brush border iron transporter DMT1.	Iron	123-127	doublesex and mab-3 related transcription factor 1	Homo sapiens	198-202
27420126-5	2001	Based on these observations, it is possible to propose a general model for the regulation of iron absorption whereby the basolateral transfer step involving Ireg1 and Hp controls the rate of absorption.	Iron	93-97	solute carrier family 40 member 1	Homo sapiens	157-162
27420126-6	2001	In this model, DMT1 expression, and hence, brush border uptake, is regulated by local iron levels that are, in turn, determined by the rate of basolateral transfer.	Iron	86-90	doublesex and mab-3 related transcription factor 1	Homo sapiens	15-19
11133941-1	2001	Genetic and biochemical studies have established that Fur and iron mediate repression of Bordetella alcaligin siderophore system (alc) genes under iron-replete nutritional growth conditions.	Iron	62-66	allantoicase	Homo sapiens	100-103
11133941-1	2001	Genetic and biochemical studies have established that Fur and iron mediate repression of Bordetella alcaligin siderophore system (alc) genes under iron-replete nutritional growth conditions.	Iron	147-151	allantoicase	Homo sapiens	100-103
11133941-2	2001	In this study, transcriptional analyses using Bordetella chromosomal alc-lacZ operon fusions determined that maximal alc gene transcriptional activity under iron starvation stress conditions is dependent on the presence of alcaligin siderophore.	Iron	157-161	allantoicase	Homo sapiens	117-120
12170286-2	2001	The product of this gene combines with the beta-2-microglobulin and the ferritin receptor, and regulates the iron absorption in the small intestine crypt cells.	Iron	109-113	beta-2-microglobulin	Homo sapiens	43-63
11120873-6	2000	The Met4, Met31, and Met32 transcription factors may play a role in coregulating genes involved in copper and iron metabolism.	Iron	110-114	Met31p	Saccharomyces cerevisiae S288C	10-15
11093950-3	2000	The process of iron transport was studied by transfection of human DMT1 into the COS-7 cell line.	Iron	15-19	doublesex and mab-3 related transcription factor 1	Homo sapiens	67-71
11093950-4	2000	Native and epitope-tagged human DMT1 led to increased iron uptake.	Iron	54-58	doublesex and mab-3 related transcription factor 1	Homo sapiens	32-36
11093950-6	2000	The pH optimum of human DMT1 iron uptake was 6.75, which is equivalent to the pH of the duodenal brush border.	Iron	29-33	doublesex and mab-3 related transcription factor 1	Homo sapiens	24-28
11093950-8	2000	Diethylpyrocarbonate inhibition of iron uptake in DMT1-transfected cells suggests a functional role for histidine residues.	Iron	35-39	doublesex and mab-3 related transcription factor 1	Homo sapiens	50-54
11085891-2	2000	Among the consequences of oxidative stress is the induction of heme oxygenase-1 (HO-1), an inducible isozyme that metabolizes heme to iron, biliverdin, and carbon monoxide.	Iron	134-138	heme oxygenase 1	Homo sapiens	63-79
11085891-2	2000	Among the consequences of oxidative stress is the induction of heme oxygenase-1 (HO-1), an inducible isozyme that metabolizes heme to iron, biliverdin, and carbon monoxide.	Iron	134-138	heme oxygenase 1	Homo sapiens	81-85
12938477-1	2000	The synthetic reactions and spectroscopic studied of molybdenum (tungsten) -copper (silver, iron) -sulphur (selenium) cluster compounds, which can be prepared by the stepwise or unit construction reactions through the successive addition ML (L = Cl, Br, Sr, R2 etc) across six edges or four faces of ME4 (M = Mo, W; E = S, Se) tetrahedra, are described.	Iron	92-96	protocadherin beta 17 pseudogene	Homo sapiens	300-303
11464482-9	2000	Consistent with this observation, ceruloplasmin gene expression is detected in the retina and basal ganglia revealing that this protein is essential for iron homeostasis neuron survival in the central nervous system.	Iron	153-157	ceruloplasmin	Homo sapiens	34-47
11068183-5	2000	However, a chemiluminescence analysis specific for reactive oxygen species (ROS) showed that ROS levels in Fe- or Al-loaded NP cells were twice as high as in Fe- or Al-loaded GP cells.	Iron	107-109	kallikrein related-peptidase 8	Rattus norvegicus	124-126
11068183-5	2000	However, a chemiluminescence analysis specific for reactive oxygen species (ROS) showed that ROS levels in Fe- or Al-loaded NP cells were twice as high as in Fe- or Al-loaded GP cells.	Iron	158-160	kallikrein related-peptidase 8	Rattus norvegicus	124-126
11068183-6	2000	Northern blot analysis and gel retardation assay showed that the Al and Fe exposure taken up by the cells suppress Tf receptor mRNA expression to a greater extent in GP than NP cells, indicating that Al and Fe more markedly accumulate in glial than in neuronal cells.	Iron	72-74	kallikrein related-peptidase 8	Rattus norvegicus	174-176
11076506-7	2000	The distance between C4a in the pteridines and the active site iron was 4.2 +/- 0.5 A for the ensemble of docked conformers.	Iron	63-67	complement C4A (Rodgers blood group)	Homo sapiens	21-24
11076506-9	2000	The pterin ring of 7-BH(4) shows proper stacking with Phe300, but the distance between the C4a and the active site iron is 0.6 A longer than for bound BH(4), a finding that may be related to the high degree of uncoupling observed for 7-BH(4).	Iron	115-119	complement C4A (Rodgers blood group)	Homo sapiens	91-94
10942763-1	2000	The human heme oxygenase-1 crystal structure suggests that Gly-139 and Gly-143 interact directly with iron-bound ligands.	Iron	102-106	heme oxygenase 1	Homo sapiens	10-26
11042124-3	2000	Nramp1 functions as an iron transporter by transporting iron into the phagosome.	Iron	23-27	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
11242441-1	2000	The structure of the iron-binding glycoprotein lactoferrin, present in milk and other exocrine secretions, has been elucidated in great detail, both the three-dimensional protein structure and the attached N-glycans.	Iron	21-25	lactotransferrin	Bos taurus	47-58
11242441-3	2000	From these studies a function for lactoferrin in host defence and modulation of iron metabolism emerges.	Iron	80-84	lactotransferrin	Bos taurus	34-45
11069629-8	2000	Terminal deoxynucleotidyl transferase-mediated desoxyuridinetriphosphate nick end labeling assay, flow cytometry with annexin-V-fluorescein and morphologic analysis indicated that iron chelation also induced a time- and concentration-dependent apoptosis.	Iron	180-184	annexin A5	Homo sapiens	118-127
11095180-1	2000	Lactoferricins are a class of antibacterial peptides isolated after gastric-pepsin digest of the mammalian iron-chelating-protein lactoferrin.	Iron	107-111	lactotransferrin	Bos taurus	130-141
11027260-8	2000	Instead, Smf3p is down-regulated by iron through a mechanism that does not involve transcription or protein stability.	Iron	36-40	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	9-14
11027260-9	2000	Smf3p localizes to the vacuolar membrane independently of metal treatment, and yeast cells lacking Smf3p show symptoms of iron starvation.	Iron	122-126	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	99-104
11027260-10	2000	We propose that Smf3p helps to mobilize vacuolar stores of iron.	Iron	59-63	putative divalent metal ion transporter SMF3	Saccharomyces cerevisiae S288C	16-21
11095929-3	2000	The aim of this study was to determine whether the recently characterized endosomal membrane iron transporter, divalent metal ion transporter-1 (DMT-1), is expressed in human syncytiotrophoblast, and whether its cellular localization would support roles for cytoplasmic and placental-fetal iron transport.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	111-143
11095929-3	2000	The aim of this study was to determine whether the recently characterized endosomal membrane iron transporter, divalent metal ion transporter-1 (DMT-1), is expressed in human syncytiotrophoblast, and whether its cellular localization would support roles for cytoplasmic and placental-fetal iron transport.	Iron	93-97	solute carrier family 11 member 2	Homo sapiens	145-150
11095929-8	2000	Subsequent transport of iron out of the endosome and across the basal membrane to the fetus may occur via DMT-1.	Iron	24-28	solute carrier family 11 member 2	Homo sapiens	106-111
11095930-0	2000	The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase.	Iron	31-35	ceruloplasmin	Homo sapiens	14-27
11095930-2	2000	Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types.	Iron	60-64	ceruloplasmin	Homo sapiens	0-13
11095930-3	2000	The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) for incorporation into transferrin.	Iron	61-65	ceruloplasmin	Homo sapiens	35-48
11095930-10	2000	We propose that this oxidase performs the same function as serum ceruloplasmin and is involved in iron release into the fetal circulation.	Iron	98-102	ceruloplasmin	Homo sapiens	65-78
11023790-0	2000	Transferrins: iron release from lactoferrin.	Iron	14-18	lactotransferrin	Bos taurus	32-43
11023790-1	2000	Iron loss in vitro by the iron scavenger bovine lactoferrin was investigated in acidic media in the presence of three different monoanions (NO(3)(-), Cl(-) and Br(-)) and one dianion (SO(4)(2-)).	Iron	0-4	lactotransferrin	Bos taurus	48-59
11023790-1	2000	Iron loss in vitro by the iron scavenger bovine lactoferrin was investigated in acidic media in the presence of three different monoanions (NO(3)(-), Cl(-) and Br(-)) and one dianion (SO(4)(2-)).	Iron	26-30	lactotransferrin	Bos taurus	48-59
11033347-2	2000	MTf has many characteristics in common with serum Tf and previous studies have shown that it can bind Fe.	Iron	102-104	melanotransferrin	Homo sapiens	0-3
11033347-3	2000	This has led to speculation that MTf may be involved in Fe transport.	Iron	56-58	melanotransferrin	Homo sapiens	33-36
11033347-4	2000	Because Fe is required for a variety of metabolic reactions including ATP and DNA synthesis, MTf could play a role in proliferation.	Iron	8-10	melanotransferrin	Homo sapiens	93-96
10985695-1	2000	Extracellular heme derived from hemoglobin following hemorrhage or released from dying cells induces the expression of heme oxygenase-1 (HO-1, HSP-32) which metabolizes heme to the gaseous mediator carbon monoxide (CO), iron (Fe) and biliverdin.	Iron	220-224	heme oxygenase 1	Homo sapiens	119-141
10985695-1	2000	Extracellular heme derived from hemoglobin following hemorrhage or released from dying cells induces the expression of heme oxygenase-1 (HO-1, HSP-32) which metabolizes heme to the gaseous mediator carbon monoxide (CO), iron (Fe) and biliverdin.	Iron	220-224	heme oxygenase 1	Homo sapiens	143-149
10985695-1	2000	Extracellular heme derived from hemoglobin following hemorrhage or released from dying cells induces the expression of heme oxygenase-1 (HO-1, HSP-32) which metabolizes heme to the gaseous mediator carbon monoxide (CO), iron (Fe) and biliverdin.	Iron	226-228	heme oxygenase 1	Homo sapiens	119-141
10985695-1	2000	Extracellular heme derived from hemoglobin following hemorrhage or released from dying cells induces the expression of heme oxygenase-1 (HO-1, HSP-32) which metabolizes heme to the gaseous mediator carbon monoxide (CO), iron (Fe) and biliverdin.	Iron	226-228	heme oxygenase 1	Homo sapiens	143-149
11015442-1	2000	Heme oxygenase 1 (HO-1) inhibits apoptosis by regulating cellular prooxidant iron.	Iron	77-81	heme oxygenase 1	Homo sapiens	0-22
11097467-1	2000	The copper-binding protein ceruloplasmin oxidizes ferrous iron to ferric iron, an action that is critical for the binding of iron to transferrin in plasma.	Iron	58-62	ceruloplasmin	Homo sapiens	27-40
11005792-2	2000	The identification of HFE, the principal determinant of adult haemochromatosis (HFE1; OMIM 235200) and TfR2, recently implicated in a rarer form of the inherited disorder (HFE3; OMIM 604250), and the promise of candidate genes for juvenile haemochromatosis (HFE2; OMIM 602390) and neonatal haemochromatosis (OMIM 231100) provide the foundation for important studies into the control mechanism of iron balance in humans.	Iron	396-400	transferrin receptor 2	Homo sapiens	103-107
11005792-2	2000	The identification of HFE, the principal determinant of adult haemochromatosis (HFE1; OMIM 235200) and TfR2, recently implicated in a rarer form of the inherited disorder (HFE3; OMIM 604250), and the promise of candidate genes for juvenile haemochromatosis (HFE2; OMIM 602390) and neonatal haemochromatosis (OMIM 231100) provide the foundation for important studies into the control mechanism of iron balance in humans.	Iron	396-400	transferrin receptor 2	Homo sapiens	172-176
10966897-1	2000	BACKGROUND: Divalent metal transporter 1 (DMT1), HFE, and stimulator of iron transport (SFT) are transmembrane proteins that have been implicated in the regulation of iron homeostasis.	Iron	72-76	solute carrier family 11 member 2	Homo sapiens	12-40
10966897-1	2000	BACKGROUND: Divalent metal transporter 1 (DMT1), HFE, and stimulator of iron transport (SFT) are transmembrane proteins that have been implicated in the regulation of iron homeostasis.	Iron	72-76	solute carrier family 11 member 2	Homo sapiens	42-46
10966897-1	2000	BACKGROUND: Divalent metal transporter 1 (DMT1), HFE, and stimulator of iron transport (SFT) are transmembrane proteins that have been implicated in the regulation of iron homeostasis.	Iron	167-171	solute carrier family 11 member 2	Homo sapiens	12-40
10966897-1	2000	BACKGROUND: Divalent metal transporter 1 (DMT1), HFE, and stimulator of iron transport (SFT) are transmembrane proteins that have been implicated in the regulation of iron homeostasis.	Iron	167-171	solute carrier family 11 member 2	Homo sapiens	42-46
10966897-2	2000	OBJECTIVE: The objective of this study was to investigate whether absorption and transepithelial movement of iron correlated with gene expression of DMT1, HFE, and SFT in an experimental model of human absorptive enterocytes.	Iron	109-113	solute carrier family 11 member 2	Homo sapiens	149-153
10966897-5	2000	In the absence of serum, iron treatment was associated with a reduction of DMT1 expression by 50% at 72 and 168 h. HFE expression was dependent on serum, but iron treatment did not alter HFE expression.	Iron	25-29	solute carrier family 11 member 2	Homo sapiens	75-79
10934254-0	2000	The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.	Iron	44-48	synuclein alpha	Homo sapiens	9-24
10934254-4	2000	Using human BE-M17 neuroblastoma cells overexpressing wild-type, A53T, or A30P alpha-synuclein, we now show that iron and free radical generators, such as dopamine or hydrogen peroxide, stimulate the production of intracellular aggregates that contain alpha-synuclein and ubiquitin.	Iron	113-117	synuclein alpha	Homo sapiens	79-94
10934254-4	2000	Using human BE-M17 neuroblastoma cells overexpressing wild-type, A53T, or A30P alpha-synuclein, we now show that iron and free radical generators, such as dopamine or hydrogen peroxide, stimulate the production of intracellular aggregates that contain alpha-synuclein and ubiquitin.	Iron	113-117	synuclein alpha	Homo sapiens	252-267
10934254-8	2000	BE-M17 neuroblastoma cells overexpressing alpha-synuclein show up to a fourfold increase in vulnerability to toxicity induced by iron.	Iron	129-133	synuclein alpha	Homo sapiens	42-57
10934254-10	2000	These data raise the possibility that alpha-synuclein acts in concert with iron and dopamine to induce formation of Lewy body pathology in PD and cell death in PD.	Iron	75-79	synuclein alpha	Homo sapiens	38-53
10911382-8	2000	Ferrous iron uptake is facilitated by DMT-1 (Nramp-2, DCT-1) in a pathway shared with manganese.	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	38-43
10911382-8	2000	Ferrous iron uptake is facilitated by DMT-1 (Nramp-2, DCT-1) in a pathway shared with manganese.	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	45-52
10911382-8	2000	Ferrous iron uptake is facilitated by DMT-1 (Nramp-2, DCT-1) in a pathway shared with manganese.	Iron	8-12	solute carrier family 11 member 2	Homo sapiens	54-59
11177225-0	2000	Biological functions of ceruloplasmin and their deficiency caused by mutation in genes regulating copper and iron metabolism.	Iron	109-113	ceruloplasmin	Homo sapiens	24-37
11177225-1	2000	Ceruloplasmin, a multicopper ferroxidase, is involved in iron and copper homeostasis and integrates these metabolic pathways.	Iron	57-61	ceruloplasmin	Homo sapiens	0-13
11177225-2	2000	Impaired biosynthesis of ceruloplasmin caused by gene mutations disturbs iron metabolism with iron deposition in different organs, especially in the basal ganglia, and severe neuronal damage.	Iron	73-77	ceruloplasmin	Homo sapiens	25-38
11177225-2	2000	Impaired biosynthesis of ceruloplasmin caused by gene mutations disturbs iron metabolism with iron deposition in different organs, especially in the basal ganglia, and severe neuronal damage.	Iron	94-98	ceruloplasmin	Homo sapiens	25-38
10751401-0	2000	Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells.	Iron	34-38	solute carrier family 11 member 2	Homo sapiens	6-12
10751401-0	2000	Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells.	Iron	34-38	solute carrier family 11 member 2	Homo sapiens	13-17
10878583-5	2000	Further, alpha-syn was implicated in the formation of the glial (GCIs) and neuronal cytoplasmic inclusions of multiple system atrophy, and the LBs, GCIs and neuraxonal spheroids of neurodegeneration with brain iron accumulation type 1.	Iron	210-214	synuclein alpha	Homo sapiens	9-18
10777486-1	2000	A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase activity and by the tissue iron overload in hereditary Cp deficiency patients.	Iron	51-55	ceruloplasmin	Homo sapiens	29-42
10777486-1	2000	A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase activity and by the tissue iron overload in hereditary Cp deficiency patients.	Iron	126-130	ceruloplasmin	Homo sapiens	29-42
11229523-9	2000	Redox processes at the cell surface, which generate cuprous ions, are involved in the regulation of the MT-1 and HO-1 genes by heme-hemopexin before heme catabolism and intracellular release of iron.	Iron	194-198	metallothionein 1I, pseudogene	Homo sapiens	104-117
10907637-3	2000	We tested the effects of iron overload or depletion on the expression of the mouse erythropoietin transgene (cDNA), driven by the hypoxia-regulated phosphoglycerate kinase 1 promoter.	Iron	25-29	erythropoietin	Mus musculus	83-97
10799651-8	2000	These data demonstrated that iron-chelating and hypoxic agents inhibited dioxin-induced Cyp1a1 transcription in Hepa-I cells.	Iron	29-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
10748212-0	2000	Identification and characterization of the iron regulatory element in the ferritin gene of a plant (soybean).	Iron	43-47	ferritin-1, chloroplastic	Glycine max	74-82
10748212-1	2000	Iron increases ferritin synthesis, targeting plant DNA and animal mRNA.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	15-23
10872750-3	2000	Iron sequestering molecules, such as ferritin, transferrin, lactotransferrin, melanotransferrin, hemosiderin and heme can serve as cytoprotectants against metal-mediated oxidant damage.	Iron	0-4	melanotransferrin	Homo sapiens	78-95
10809955-5	2000	Consistent with the protein having direct anti-inflammatory properties, it was found that the intradermal injection of recombinant murine LF (either iron-saturated or iron-depleted LF) inhibited significantly allergen (oxazolone) -induced LC migration and DC accumulation.	Iron	149-153	lactotransferrin	Mus musculus	138-140
10809955-5	2000	Consistent with the protein having direct anti-inflammatory properties, it was found that the intradermal injection of recombinant murine LF (either iron-saturated or iron-depleted LF) inhibited significantly allergen (oxazolone) -induced LC migration and DC accumulation.	Iron	167-171	lactotransferrin	Mus musculus	138-140
10809955-5	2000	Consistent with the protein having direct anti-inflammatory properties, it was found that the intradermal injection of recombinant murine LF (either iron-saturated or iron-depleted LF) inhibited significantly allergen (oxazolone) -induced LC migration and DC accumulation.	Iron	167-171	lactotransferrin	Mus musculus	181-183
10865496-4	2000	The resulting hyperabsorption, which forms the basis of iron overload in hemochromatosis, is likely to implicate an overexpression of the transmembrane iron carrier DMT1.	Iron	56-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	165-169
10865496-4	2000	The resulting hyperabsorption, which forms the basis of iron overload in hemochromatosis, is likely to implicate an overexpression of the transmembrane iron carrier DMT1.	Iron	152-156	doublesex and mab-3 related transcription factor 1	Homo sapiens	165-169
10831768-1	2000	Aceruloplasminemia is characterized by excessive neurovisceral accumulation of iron due to mutations in the ceruloplasmin gene.	Iron	79-83	ceruloplasmin	Homo sapiens	1-14
10733947-4	2000	The relationship between heme oxygenase-1 activation and iron metabolism was investigated by measurement of activities of both cytosolic and mitochondrial cis-aconitase enzymes.	Iron	57-61	heme oxygenase 1	Homo sapiens	25-41
10733947-6	2000	We propose that modulation of cis-aconitase activity at the translational level by an increase of cellular iron is an important consequence of heme oxygenase-1 activation.	Iron	107-111	heme oxygenase 1	Homo sapiens	143-159
11232594-2	2000	The precipitating cause of such oxidative stress may be misregulated iron homeostasis because there are profound alterations in heme oxygenase-1 (HO-1), redox-active iron, and iron regulatory proteins.	Iron	69-73	heme oxygenase 1	Homo sapiens	128-144
11232594-2	2000	The precipitating cause of such oxidative stress may be misregulated iron homeostasis because there are profound alterations in heme oxygenase-1 (HO-1), redox-active iron, and iron regulatory proteins.	Iron	69-73	heme oxygenase 1	Homo sapiens	146-150
10751730-9	2000	These results suggest that the lack of p53 gene function may play a role in the iron particle radiation-induced genomic instability in stem cell populations in the hematopoietic system.	Iron	80-84	transformation related protein 53, pseudogene	Mus musculus	39-42
10754275-2	2000	Direct low-temperature (11 degrees K) EPR analysis of the cytochrome c heme iron on exposure to tert-BuOOH shows a gradual (180 s) conversion of the low-spin form to a high-spin Fe(III) species of rhombic symmetry (g = 4.3), with disappearance of a prior peroxyl radical signal (g(o) = 2.014).	Iron	76-80	telomerase reverse transcriptase	Homo sapiens	96-100
10754275-7	2000	The EPR results show that the primary initial change on exposure of cytochrome c to tert-BuOOH is a change to a high-spin Fe(III) species, and together with MCD measurements show that unsaturated cardiolipin-containing lipid membranes influence the interaction of tert-BuOOH with cytochrome c heme iron, to alter radical production and decrease damage to the cytochrome.	Iron	298-302	telomerase reverse transcriptase	Homo sapiens	84-88
11443994-0	2000	Phosphate, nitrogen and iron enrichment in the polluted Izmir Bay, Aegean Sea.	Iron	24-28	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	74-77
10666301-1	2000	When added to human blood serum, the iron-binding protein lactoferrin (LF) purified from breast milk interacts with ceruloplasmin (CP), a copper-containing oxidase.	Iron	37-41	ceruloplasmin	Homo sapiens	116-129
10785872-2	2000	Authors of a recent study identified a mutation in HLA-H gene, C282Y, that is an excellent marker for hemochromatosis, which is the most common cause of iron overload.	Iron	153-157	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	51-56
10625641-0	2000	Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells.	Iron	50-54	solute carrier family 11 member 2	Homo sapiens	0-6
10625641-4	2000	Here we demonstrate that Nramp2 is expressed in the apical membrane of the human intestinal epithelial cell line, Caco 2 TC7, and is associated with functional iron transport in these cells with a substrate preference for iron over other divalent cations.	Iron	160-164	solute carrier family 11 member 2	Homo sapiens	25-31
10625641-4	2000	Here we demonstrate that Nramp2 is expressed in the apical membrane of the human intestinal epithelial cell line, Caco 2 TC7, and is associated with functional iron transport in these cells with a substrate preference for iron over other divalent cations.	Iron	222-226	solute carrier family 11 member 2	Homo sapiens	25-31
10625641-6	2000	Taken together, these data suggest that the expression of the Nramp2 transporter in human enterocytes may play an important role in intestinal iron absorption.	Iron	143-147	solute carrier family 11 member 2	Homo sapiens	62-68
10813095-0	2000	Role of melanotransferrin (p97) in non-transferrin iron uptake by HeLa and K562 cells.	Iron	51-55	melanotransferrin	Homo sapiens	8-25
10813095-0	2000	Role of melanotransferrin (p97) in non-transferrin iron uptake by HeLa and K562 cells.	Iron	51-55	melanotransferrin	Homo sapiens	27-30
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	46-50	melanotransferrin	Homo sapiens	18-35
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	46-50	melanotransferrin	Homo sapiens	37-40
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	139-143	melanotransferrin	Homo sapiens	18-35
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	139-143	melanotransferrin	Homo sapiens	37-40
10631128-0	2000	CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.	Iron	75-79	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	0-6
10631128-1	2000	Using Cyp1a2(-/-) mice we previously showed that CYP1A2 is absolutely required for hepatic uroporphyrin accumulation caused by iron and 5-aminolevulinate (ALA) treatment, both in the presence and absence of an inducer of CYP1A2.	Iron	127-131	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	49-55
10631128-4	2000	In iron-loaded wild-type mice given a single dose of HCBZ and ALA, hepatic uroporphyrin (URO) accumulated to 300 nmol/g liver after 37 days, whereas in Cyp1a2(-/-) mice, there was no hepatic URO, even after an additional dose of HCBZ, and a further 29 days of ALA treatment.	Iron	3-7	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	152-158
10631128-5	2000	A similar requirement for CYP1A2 was found in uroporphyria produced in HCBZ and iron-treated mice in the absence of ALA.	Iron	80-84	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	26-32
10600167-5	1999	V(max) values for iron oxidation by P. pastoris Fet3 were obtained similar to human ceruloplasmin and much higher than those reported for Saccharomyces cerevisiae Fet3.	Iron	18-22	ceruloplasmin	Homo sapiens	84-97
10572107-2	1999	Hx has a high binding affinity with heme and is considered to be a major transport vehicle of heme into the liver, thus preventing both heme-catalyzed oxidative damage and heme-bound iron loss.	Iron	183-187	hemopexin	Mus musculus	0-2
10572107-8	1999	After hemolytic stimulus, Hx-deficient mice presented prolonged hemoglobinuria with a higher kidney iron load and higher lipid peroxidation than control mice.	Iron	100-104	hemopexin	Mus musculus	26-28
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	121-125	heme oxygenase 1	Homo sapiens	42-58
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	121-125	heme oxygenase 1	Homo sapiens	60-64
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	127-129	heme oxygenase 1	Homo sapiens	42-58
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	127-129	heme oxygenase 1	Homo sapiens	60-64
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	172-174	heme oxygenase 1	Homo sapiens	42-58
10589693-4	1999	Induction of the heme catabolizing enzyme heme oxygenase-1 (HO-1), which generates biliverdin, carbon monoxide (CO), and iron (Fe), may provide such a mechanism, as CO and Fe are two negative modulators of iNOS activity and expression.	Iron	172-174	heme oxygenase 1	Homo sapiens	60-64
10582610-1	1999	Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation, which accumulates in the brain during neurodegenerative disorders.	Iron	23-27	lactotransferrin	Bos taurus	0-11
10582610-1	1999	Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation, which accumulates in the brain during neurodegenerative disorders.	Iron	23-27	lactotransferrin	Bos taurus	13-15
10577506-0	1999	Nramp1: a link between intracellular iron transport and innate resistance to intracellular pathogens.	Iron	37-41	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
10577506-5	1999	Nramp1 exhibits sequence identity to Nramp2, which regulates intestinal and reticulocyte iron uptake.	Iron	89-93	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
10577506-7	1999	Nramp1 expression supports increased acute cytoplasmic influx of iron, detected using the fluorescent iron sensor dye calcein.	Iron	65-69	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
10577506-7	1999	Nramp1 expression supports increased acute cytoplasmic influx of iron, detected using the fluorescent iron sensor dye calcein.	Iron	102-106	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	0-6
10577506-8	1999	Analysis of the endogenous iron sensors, iron regulatory protein 1 and 2, reveals a greater flux of iron in Nramp1-expressing cells and in its exclusion from the cytoplasm.	Iron	27-31	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	108-114
10577506-8	1999	Analysis of the endogenous iron sensors, iron regulatory protein 1 and 2, reveals a greater flux of iron in Nramp1-expressing cells and in its exclusion from the cytoplasm.	Iron	41-45	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	108-114
10529220-8	1999	268, 6995-7010] that a mutation at position 29 (B10, helix notation), e.g. , Leu --&gt; Phe, can inhibit the autoxidation of the heme iron of myoglobin.	Iron	134-138	myoglobin	Homo sapiens	142-151
10552243-7	1999	Enhanced CSF lactoferrin may reflect an increased iron transport requirement in the central nervous system in superficial siderosis and might be a useful measure for monitoring response to therapy.	Iron	50-54	colony stimulating factor 2	Homo sapiens	9-12
10508415-1	1999	Ceruloplasmin, a blue multi-copper alpha(2)-glycoprotein found in the plasma of all vertebrates, is capable of oxidizing aromatic amines and ferrous iron.	Iron	141-153	ceruloplasmin	Homo sapiens	0-13
12835114-4	1999	Dopamine-induced mitochondrial iron trapping was abrogated by administration of the heme oxygenase inhibitors, tin mesoporphyrin (SnMP) or dexamethasone (DEX) indicating that HO-1 upregulation is necessary for subsequent mitochondrial iron deposition in these cells.	Iron	31-35	heme oxygenase 1	Homo sapiens	175-179
12835114-4	1999	Dopamine-induced mitochondrial iron trapping was abrogated by administration of the heme oxygenase inhibitors, tin mesoporphyrin (SnMP) or dexamethasone (DEX) indicating that HO-1 upregulation is necessary for subsequent mitochondrial iron deposition in these cells.	Iron	235-239	heme oxygenase 1	Homo sapiens	175-179
12835114-5	1999	Overexpression of the human HO-1 gene in cultured rat astroglia by transient transfection also stimulated mitochondrial (55)Fe deposition, an effect that was again preventible by SnMP or DEX administration.	Iron	124-126	heme oxygenase 1	Homo sapiens	28-32
12835114-6	1999	We hypothesize that free ferrous iron and carbon monoxide generated by HO-1-mediated heme degradation promote mitochondrial membrane injury and the deposition of redox-active iron within this organelle.	Iron	33-37	heme oxygenase 1	Homo sapiens	71-75
12835114-6	1999	We hypothesize that free ferrous iron and carbon monoxide generated by HO-1-mediated heme degradation promote mitochondrial membrane injury and the deposition of redox-active iron within this organelle.	Iron	175-179	heme oxygenase 1	Homo sapiens	71-75
12835114-8	1999	Stress-induced up-regulation of HO-1 in astroglia may be responsible for the abnormal patterns of brain iron deposition and mitochondrial insufficiency documented in various human neurodegenerative disorders.	Iron	104-108	heme oxygenase 1	Homo sapiens	32-36
10382697-2	1999	Iron absorption is regulated by the duodenal metal transporter, DMT-1, also called NRAMP-2.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	64-69
10382697-2	1999	Iron absorption is regulated by the duodenal metal transporter, DMT-1, also called NRAMP-2.	Iron	0-4	solute carrier family 11 member 2	Homo sapiens	83-90
10382697-11	1999	INTERPRETATION: Increased NRAMP-2 mRNA expression in duodenal mucosa of patients with hereditary haemochromatosis may promote duodenal iron uptake and lead to iron overload.	Iron	135-139	solute carrier family 11 member 2	Homo sapiens	26-33
10382697-11	1999	INTERPRETATION: Increased NRAMP-2 mRNA expression in duodenal mucosa of patients with hereditary haemochromatosis may promote duodenal iron uptake and lead to iron overload.	Iron	159-163	solute carrier family 11 member 2	Homo sapiens	26-33
10401616-0	1999	Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?	Iron	26-30	ceruloplasmin	Homo sapiens	92-105
10401616-4	1999	To begin to address this issue, here we investigated ceruloplasmin, a key protein involved in the regulation of the redox state of iron by converting iron (II) to iron (III).	Iron	131-135	ceruloplasmin	Homo sapiens	53-66
10401616-4	1999	To begin to address this issue, here we investigated ceruloplasmin, a key protein involved in the regulation of the redox state of iron by converting iron (II) to iron (III).	Iron	150-154	ceruloplasmin	Homo sapiens	53-66
10401616-8	1999	Therefore, a failure of neuronal ceruloplasmin to respond to iron may be an important factor that then leads to an accumulation of redox-active iron in neurons in AD.	Iron	61-65	ceruloplasmin	Homo sapiens	33-46
10401616-8	1999	Therefore, a failure of neuronal ceruloplasmin to respond to iron may be an important factor that then leads to an accumulation of redox-active iron in neurons in AD.	Iron	144-148	ceruloplasmin	Homo sapiens	33-46
10354297-1	1999	BACKGROUND: Inadequate iron mobilization and defective iron utilization may cause recombinant erythropoietin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	23-27	erythropoietin	Rattus norvegicus	110-114
10354297-1	1999	BACKGROUND: Inadequate iron mobilization and defective iron utilization may cause recombinant erythropoietin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	55-59	erythropoietin	Rattus norvegicus	110-114
10354297-1	1999	BACKGROUND: Inadequate iron mobilization and defective iron utilization may cause recombinant erythropoietin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload.	Iron	55-59	erythropoietin	Rattus norvegicus	110-114
10380640-0	1999	Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives.	Iron	14-18	lactotransferrin	Bos taurus	91-102
10222384-0	1999	Immunological analysis of beta-thalassemic mouse intestinal proteins reveals up-regulation of sucrase-isomaltase in response to iron overload.	Iron	128-132	sucrase isomaltase (alpha-glucosidase)	Mus musculus	94-112
10205052-1	1999	The crystal structures of myoglobin in the deoxy- and carbon monoxide-ligated states at a resolution of 1.15 angstroms show that carbon monoxide binding at ambient temperatures requires concerted motions of the heme, the iron, and helices E and F for relief of steric inhibition.	Iron	221-225	myoglobin	Homo sapiens	26-35
10092489-4	1999	This may indicate that the long-term expression and accumulation of p97 is inhibitory to Drosophila cells, possibly due to improper localization of the protein and resultant competition for cellular iron.	Iron	199-203	Regulatory particle non-ATPase 1	Drosophila melanogaster	68-71
10090762-1	1999	The H25C and H25Y mutants of human heme oxygenase-1 (hHO-1), in which the proximal iron ligand is replaced by a cysteine or tyrosine, have been expressed and characterized.	Iron	83-87	heme oxygenase 1	Homo sapiens	35-51
10090762-1	1999	The H25C and H25Y mutants of human heme oxygenase-1 (hHO-1), in which the proximal iron ligand is replaced by a cysteine or tyrosine, have been expressed and characterized.	Iron	83-87	heme oxygenase 1	Homo sapiens	53-58
10205296-3	1999	The bond between Fe and proximal His-F8 allows additional integration of the structures of the heme cavity and the myoglobin molecule as a whole, providing its functional activity and highly cooperative conformational transitions.	Iron	2-4	myoglobin	Homo sapiens	116-125
10024586-0	1999	Role of iron in Nramp1-mediated inhibition of mycobacterial growth.	Iron	8-12	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	16-22
10049947-3	1999	Nramp2 has a much broader range of tissue expression and mutations at Nramp2 result in iron deficiency, indicating a role for Nramp2 in iron metabolism.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	70-76
10049947-3	1999	Nramp2 has a much broader range of tissue expression and mutations at Nramp2 result in iron deficiency, indicating a role for Nramp2 in iron metabolism.	Iron	87-91	solute carrier family 11 member 2	Homo sapiens	70-76
10049947-9	1999	These findings suggest that Nramp2 plays a key role in the metabolism of transferrin-bound iron by transporting free Fe2+ across the endosomal membrane and into the cytoplasm.	Iron	91-95	solute carrier family 11 member 2	Homo sapiens	28-34
10096297-0	1999	Iron fortification of rice seed by the soybean ferritin gene.	Iron	0-4	ferritin-1, chloroplastic	Glycine max	47-55
9915882-1	1999	The newly identified hemochromatosis gene, HFE, and a candidate iron transporter gene, Nramp2, have been proposed as key factors responsible for the regulation of intestinal iron absorption.	Iron	64-68	solute carrier family 11 member 2	Homo sapiens	87-93
9915900-7	1999	Long-term right-sided Nissl substance loss occurred in CA1 (P = 0.001), CA3a,b (P &lt; 0.001) and dentate gyrus (P = 0.008) in the iron-deficient group, but only in CA1 (P = 0.004) in the iron-sufficient group.	Iron	131-135	carbonic anhydrase 1	Rattus norvegicus	55-58
9915900-7	1999	Long-term right-sided Nissl substance loss occurred in CA1 (P = 0.001), CA3a,b (P &lt; 0.001) and dentate gyrus (P = 0.008) in the iron-deficient group, but only in CA1 (P = 0.004) in the iron-sufficient group.	Iron	131-135	carbonic anhydrase 1	Rattus norvegicus	165-168
9881510-4	1998	Lactoferrin inhibition of growth could be reversed by addition of excess iron to the medium.	Iron	73-77	lactotransferrin	Mus musculus	0-11
9823544-3	1998	Purified human gamma-glutamyltransferase (GGT) in the presence of 2 mM glutathione (GSH) and 80 microM transferrin, as an iron source, at pH 7.4 generates ROS, as measured by chemiluminescence of luminol.	Iron	122-126	gamma-glutamyltransferase light chain family member 3	Homo sapiens	15-40
9823544-3	1998	Purified human gamma-glutamyltransferase (GGT) in the presence of 2 mM glutathione (GSH) and 80 microM transferrin, as an iron source, at pH 7.4 generates ROS, as measured by chemiluminescence of luminol.	Iron	122-126	gamma-glutamyltransferase light chain family member 3	Homo sapiens	42-45
9823544-9	1998	We further confirmed the hypothesis that cysteinylglycine (CysGly), a product of GGT/GSH reaction, identified by high-performance liquid chromatography, but not GSH, was responsible for ROS formation initiated by the reductive release of iron from transferrin.	Iron	238-242	gamma-glutamyltransferase light chain family member 3	Homo sapiens	81-84
9808632-5	1998	Nramp2 is likely to be the membrane transporter that functions in controlling iron entry across the apical membrane and in the export of iron out of endosomal vesicles.	Iron	78-82	solute carrier family 11 member 2	Homo sapiens	0-6
9808632-5	1998	Nramp2 is likely to be the membrane transporter that functions in controlling iron entry across the apical membrane and in the export of iron out of endosomal vesicles.	Iron	137-141	solute carrier family 11 member 2	Homo sapiens	0-6
9808632-6	1998	The observation that the expression of both HFE and Nramp2 mRNAs are reciprocally regulated by cellular iron status in Caco-2 cells, a human intestinal cell line, lends additional credence to the notion that these proteins may work in concert to regulate intestinal iron absorption.	Iron	104-108	solute carrier family 11 member 2	Homo sapiens	52-58
9808632-6	1998	The observation that the expression of both HFE and Nramp2 mRNAs are reciprocally regulated by cellular iron status in Caco-2 cells, a human intestinal cell line, lends additional credence to the notion that these proteins may work in concert to regulate intestinal iron absorption.	Iron	266-270	solute carrier family 11 member 2	Homo sapiens	52-58
9736020-5	1998	Myoglobin heme iron could potentially serve as a Fenton reagent for the intracellular generation of hydroxyl radicals, which are responsible for the oxidation of the porphyrinogens.	Iron	15-19	myoglobin	Homo sapiens	0-9
9712849-10	1998	In the case of the ferrochelatase iron-sulfur cluster ligands, NH2-Cys-X206-Cys-X2-Cys-X4-Cys-COOH, the position distant from other ligands may lead to a spatial positioning of the cluster near the enzyme active site or at the interface of two domains, thereby explaining the loss of enzyme activity that accompanies cluster degradation and reinforcing the idea that the cluster functions as a regulatory switch.	Iron	34-38	Ferrochelatase	Drosophila melanogaster	19-33
9828853-3	1998	HO-1 catabolises heme to bilirubin, free iron, and carbon monoxide (CO).	Iron	41-45	heme oxygenase 1	Homo sapiens	0-4
9705901-0	1998	Association of glutathione S-transferase isozyme-specific induction and lipid peroxidation in two inbred strains of mice subjected to chronic dietary iron overload.	Iron	150-154	hematopoietic prostaglandin D synthase	Mus musculus	15-40
9705901-2	1998	The effect of iron-induced lipid peroxidation on induction of glutathione S-transferase (GST) isozymes A1 and A4 in the livers of male C57/BL6Ibg and DBA/J2Ibg mice was studied.	Iron	14-18	hematopoietic prostaglandin D synthase	Mus musculus	62-87
9705901-2	1998	The effect of iron-induced lipid peroxidation on induction of glutathione S-transferase (GST) isozymes A1 and A4 in the livers of male C57/BL6Ibg and DBA/J2Ibg mice was studied.	Iron	14-18	hematopoietic prostaglandin D synthase	Mus musculus	89-92
9626057-4	1998	These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.	Iron	36-40	microtubule associated protein tau	Homo sapiens	73-76
15012226-4	1998	These have led to the discovery of NifS-homologues and cysteine desulfhydrase for iron-sulfur center assembly, six loci (CCS1-CCS5, ccsA) for c-type cytochrome assembly, four loci for cytochrome b6 assembly (CCB1-CCB4), the CtpA protease, which is involved in pre-D1 processing, and the PCY2 locus, which is involved in holoplastocyanin accumulation.	Iron	82-86	cytochrome b	Arabidopsis thaliana	184-196
15012226-4	1998	These have led to the discovery of NifS-homologues and cysteine desulfhydrase for iron-sulfur center assembly, six loci (CCS1-CCS5, ccsA) for c-type cytochrome assembly, four loci for cytochrome b6 assembly (CCB1-CCB4), the CtpA protease, which is involved in pre-D1 processing, and the PCY2 locus, which is involved in holoplastocyanin accumulation.	Iron	82-86	cofactor assembly of complex C	Arabidopsis thaliana	213-217
9633612-0	1998	Evidence for a protein-protein complex during iron loading into ferritin by ceruloplasmin.	Iron	46-50	ceruloplasmin	Homo sapiens	76-89
9633612-1	1998	The formation of a protein-protein complex for the loading of iron into ferritin by ceruloplasmin was investigated.	Iron	62-66	ceruloplasmin	Homo sapiens	84-97
9633612-9	1998	Including ferrous iron in the gradient resulted in reduction of ceruloplasmin and increased the mobility of ceruloplasmin with ferritin.	Iron	10-22	ceruloplasmin	Homo sapiens	64-77
9633612-9	1998	Including ferrous iron in the gradient resulted in reduction of ceruloplasmin and increased the mobility of ceruloplasmin with ferritin.	Iron	10-22	ceruloplasmin	Homo sapiens	108-121
9633612-10	1998	These data provide evidence that ferritin and ceruloplasmin form a protein-protein complex during iron loading into ferritin, which may limit redox cycling of iron in vivo.	Iron	98-102	ceruloplasmin	Homo sapiens	46-59
9633612-10	1998	These data provide evidence that ferritin and ceruloplasmin form a protein-protein complex during iron loading into ferritin, which may limit redox cycling of iron in vivo.	Iron	159-163	ceruloplasmin	Homo sapiens	46-59
9764098-11	1998	The cancer risk in the pig iron department may be due to a combination of exposures to PAH, asbestos, or dust of mixed composition.	Iron	27-31	phenylalanine hydroxylase	Sus scrofa	87-90
9587138-2	1998	Clinical and pathologic studies in patients with aceruloplasminemia revealed a marked accumulation of iron in affected parenchymal tissues, a finding consistent with early work identifying ceruloplasmin as a ferroxidase and with recent findings showing an essential role for a homologous copper oxidase in iron metabolism in yeast.	Iron	102-106	ceruloplasmin	Homo sapiens	50-63
9587138-2	1998	Clinical and pathologic studies in patients with aceruloplasminemia revealed a marked accumulation of iron in affected parenchymal tissues, a finding consistent with early work identifying ceruloplasmin as a ferroxidase and with recent findings showing an essential role for a homologous copper oxidase in iron metabolism in yeast.	Iron	306-310	ceruloplasmin	Homo sapiens	50-63
9587138-3	1998	The presence of neurologic symptoms in aceruloplasminemia is unique among the known inherited and acquired disorders of iron metabolism; recent studies revealed an essential role for astrocyte-specific expression of ceruloplasmin in iron metabolism and neuronal survival in the central nervous system.	Iron	120-124	ceruloplasmin	Homo sapiens	40-53
9612298-8	1998	Both PMN adhesion and P-selectin presentation were blocked by 0.1 mM desferrioxamine (an iron chelator) and 1 mM methionine (an oxyradical scavenger).	Iron	89-93	selectin P	Homo sapiens	22-32
9629304-7	1998	The Nramp1 gene product appears to protect the mRNA of macrophage activation genes from degradation induced by corticosterone by an iron-dependent mechanism.	Iron	132-136	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	4-10
9626590-2	1998	Experiments were carried out to evaluate the ability of CYP1A1, 1A2, 2B6, and 3A4 to consume NADPH, reduce iron, and catalyze production of reactive oxygen species.	Iron	107-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
9658732-11	1998	However, other proteins are involved in iron uptake, as the recently cloned Nramp2, the first iron transporter discovered in mammalians.	Iron	40-44	solute carrier family 11 member 2	Homo sapiens	76-82
9658732-12	1998	Nramp2 has a recognized role both in the intestinal iron uptake and in the iron transport within the erythroblast.	Iron	52-56	solute carrier family 11 member 2	Homo sapiens	0-6
9658732-12	1998	Nramp2 has a recognized role both in the intestinal iron uptake and in the iron transport within the erythroblast.	Iron	75-79	solute carrier family 11 member 2	Homo sapiens	0-6
9500700-8	1998	The incubation of HSC for 24 hours with HCM/Fe significantly increased baseline intracellular pH (pHi) and Na+/H+ exchanger activity, indicating a plausible role of this antiport in mediating cell response.	Iron	44-46	glucose-6-phosphate isomerase	Rattus norvegicus	98-101
9486970-8	1998	These results demonstrate that the absence of HO-2 is associated with induction of HO-1 and increased oxygen toxicity in vivo, apparently due to accumulation of lung iron.	Iron	166-170	heme oxygenase 2	Mus musculus	46-50
9486970-9	1998	These results suggest that HO-2 functions to augment the turnover of lung iron during oxidative stress, and that this function does not appear to be compensated for by induction of HO-1 in the knockouts.	Iron	74-78	heme oxygenase 2	Mus musculus	27-31
9413925-4	1998	In both the iron-loaded and chronically alcoholised macrophages, there was a significant diminution in nitric oxide release after stimulation with lipopolysaccharide and/or interferon-gamma, which impaired the ability of both of these groups of macrophages to inhibit the germination of spores from the fungus Rhizopus, a nitric oxide-dependent process.	Iron	12-16	interferon gamma	Rattus norvegicus	173-189
9451424-8	1998	Our data suggest that deprivation of cellular iron induces downregulation of c-myc expression in vitro and in vivo and may influence haemopoietic cell growth and survival.	Iron	46-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	77-82
9434181-8	1997	Interestingly, while both human and murine lactoferrin bind iron in a 2:1 molar ratio, iron bound to recombinant murine lactoferrin was more acid labile than human lactoferrin, demonstrating species-specific variation in the stability of iron-binding to this protein.	Iron	60-64	lactotransferrin	Mus musculus	43-54
9434181-8	1997	Interestingly, while both human and murine lactoferrin bind iron in a 2:1 molar ratio, iron bound to recombinant murine lactoferrin was more acid labile than human lactoferrin, demonstrating species-specific variation in the stability of iron-binding to this protein.	Iron	87-91	lactotransferrin	Mus musculus	120-131
9434181-8	1997	Interestingly, while both human and murine lactoferrin bind iron in a 2:1 molar ratio, iron bound to recombinant murine lactoferrin was more acid labile than human lactoferrin, demonstrating species-specific variation in the stability of iron-binding to this protein.	Iron	87-91	lactotransferrin	Mus musculus	120-131
9434181-8	1997	Interestingly, while both human and murine lactoferrin bind iron in a 2:1 molar ratio, iron bound to recombinant murine lactoferrin was more acid labile than human lactoferrin, demonstrating species-specific variation in the stability of iron-binding to this protein.	Iron	87-91	lactotransferrin	Mus musculus	120-131
9434181-8	1997	Interestingly, while both human and murine lactoferrin bind iron in a 2:1 molar ratio, iron bound to recombinant murine lactoferrin was more acid labile than human lactoferrin, demonstrating species-specific variation in the stability of iron-binding to this protein.	Iron	87-91	lactotransferrin	Mus musculus	120-131
9393673-0	1997	Dinitrosyl-dithiol-iron complexes, nitric oxide (NO) carriers in vivo, as potent inhibitors of human glutathione reductase and glutathione-S-transferase.	Iron	19-23	glutathione S-transferase kappa 1	Homo sapiens	127-152
9395268-5	1997	The iron chelator desferrioxamine significantly prevented the reduction of antithrombin III binding to LNA-treated cells.	Iron	4-8	serpin family C member 1	Homo sapiens	75-91
9427294-1	1997	Lactoferrin is a secreted iron binding protein which is expressed during normal functional development of mammary epithelium.	Iron	26-30	lactotransferrin	Mus musculus	0-11
9406953-1	1997	We previously reported that iron deposition was seen in the cerebral cortex and hippocampal CA1 area late after transient forebrain ischemia generated by four-vessel occlusion in rats.	Iron	28-32	carbonic anhydrase 1	Rattus norvegicus	92-95
9406953-2	1997	Iron deposition in the hippocampal CA1 area was coupled with delayed pyramidal cell death, while that in the cerebral cortex was not accompanied by neuronal death or atrophy until 6 months after ischemia.	Iron	0-4	carbonic anhydrase 1	Rattus norvegicus	35-38
9380736-1	1997	Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron.	Iron	141-145	heme oxygenase 1	Homo sapiens	37-53
9380736-1	1997	Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron.	Iron	141-145	heme oxygenase 1	Homo sapiens	55-60
9200812-1	1997	High-affinity iron uptake in Saccharomyces cerevisiae involves the extracytoplasmic reduction of ferric ions by FRE1 and FRE2 reductases.	Iron	14-18	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	121-125
9200812-5	1997	Aft1 protein is required for maintaining detectable non-induced level of FET3 expression and for induction of FRE2 in iron starvation conditions.	Iron	118-122	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	110-114
9183693-13	1997	The association of TfBP in these specific cell types responsible for myelination and sequestering iron and transferrin implies that TfBP may be involved in myelination and iron metabolism of the chick nervous system, perhaps through a role in transferrin concentration in these cells.	Iron	98-102	heat shock protein 90 beta family member 1	Gallus gallus	132-136
9183693-13	1997	The association of TfBP in these specific cell types responsible for myelination and sequestering iron and transferrin implies that TfBP may be involved in myelination and iron metabolism of the chick nervous system, perhaps through a role in transferrin concentration in these cells.	Iron	172-176	heat shock protein 90 beta family member 1	Gallus gallus	132-136
9153234-1	1997	Fre1p and Fre2p are ferric reductases which account for the total plasma membrane associated activity, a prerequisite for iron uptake, in Saccharomyces cerevisiae.	Iron	122-126	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	10-15
9116047-1	1997	Heme oxygenase-2 (HO-2) is constitutively expressed in mammalian tissues; together with HO-1 (HSP32) it catalyzes the cleavage of heme to produce biliverdin IX alpha, CO and Fe.	Iron	174-176	heme oxygenase 1	Homo sapiens	88-92
9116047-1	1997	Heme oxygenase-2 (HO-2) is constitutively expressed in mammalian tissues; together with HO-1 (HSP32) it catalyzes the cleavage of heme to produce biliverdin IX alpha, CO and Fe.	Iron	174-176	heme oxygenase 1	Homo sapiens	94-99
9122230-8	1997	Here we show that the HLA-H protein not only varies in its pattern of expression along the cranial/caudal axis of the gastrointestinal tract but that it has a unique subcellular localization in the crypts of the small intestine in proximity to the presumed sites of iron absorption.	Iron	266-270	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	22-27
9257124-1	1997	This study uses microsomal membranes from rat testis tissue, including the cytochrome P450c17 (steroid 17 alpha-monooxygenase/17 alpha-hydroxyprogesterone aldolase, catalyzing the conversion of progesterone to androstenedione), to decipher the possible relation of NADPH-induced (no exogenous iron added) lipid peroxidation and cytochrome P450 inactivation and the protective effect of certain steroids.	Iron	293-297	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	75-93
9149329-5	1997	In normal and major depressed subjects, there were significant and positive relationships between serum DPP IV activity and total serum protein, serum albumin, zinc, iron and transferrin.	Iron	166-170	dipeptidyl peptidase 4	Homo sapiens	104-110
9002972-4	1997	We show that, in human (K562) and murine erythroleukemic cells (MEL), Epo enhances the binding affinity of iron-regulatory protein (IRP)-1, the central regulator of cellular iron metabolism, to specific RNA stem-loop structures, known as iron-responsive elements (IREs).	Iron	107-111	erythropoietin	Mus musculus	70-73
9002972-4	1997	We show that, in human (K562) and murine erythroleukemic cells (MEL), Epo enhances the binding affinity of iron-regulatory protein (IRP)-1, the central regulator of cellular iron metabolism, to specific RNA stem-loop structures, known as iron-responsive elements (IREs).	Iron	174-178	erythropoietin	Mus musculus	70-73
9025264-4	1997	The capillary isoelectric focusing (CIEF) method was applied to the analysis of chicken conalbumin (ovotransferrin), an iron-binding protein in egg white.	Iron	120-124	transferrin (ovotransferrin)	Gallus gallus	88-98
9025264-4	1997	The capillary isoelectric focusing (CIEF) method was applied to the analysis of chicken conalbumin (ovotransferrin), an iron-binding protein in egg white.	Iron	120-124	transferrin (ovotransferrin)	Gallus gallus	100-114
9025264-5	1997	Conalbumin (low iron content) separated into three major components with p/s of 7.2, 6.6 and 6.2.	Iron	16-20	transferrin (ovotransferrin)	Gallus gallus	0-10
9119254-4	1997	In rat liver microsomes (chosen as model membrane lipid substrate) exposed to GSH and ADP-chelated iron, the addition of GGT caused a marked stimulation of lipid peroxidation, which was further enhanced by the addition of the GGT co-substrate glycyl-glycine.	Iron	99-103	gamma-glutamyltransferase 1	Rattus norvegicus	121-124
9107091-15	1997	If it is unequivocally confirmed that the HLA-H gene is responsible for the disease, understanding of its biological function will provide information on the type and activity of the involved protein, revealing new insights into iron uptake and metabolism in humans.	Iron	229-233	major histocompatibility complex, class I, H (pseudogene)	Homo sapiens	42-47
9116643-7	1996	Scatchard plot analysis of the binding of peroxidase-labeled bovine lactoferrin to H. pylori cells yielded a kd 2.88 x 10(-6) M. In addition, binding of H. pylori cells to bovine lactoferrin was enhanced when bacteria treated with pepsin or alpha-chymotrypsin after isolation from iron-restricted and iron-containing media.	Iron	281-285	lactotransferrin	Bos taurus	68-79
9116643-7	1996	Scatchard plot analysis of the binding of peroxidase-labeled bovine lactoferrin to H. pylori cells yielded a kd 2.88 x 10(-6) M. In addition, binding of H. pylori cells to bovine lactoferrin was enhanced when bacteria treated with pepsin or alpha-chymotrypsin after isolation from iron-restricted and iron-containing media.	Iron	301-305	lactotransferrin	Bos taurus	68-79
8898750-0	1996	Serum levels of the iron binding protein p97 are elevated in Alzheimer"s disease.	Iron	20-24	melanotransferrin	Homo sapiens	41-44
8898750-4	1996	Here we provide evidence that the soluble form of the iron binding protein p97 is found in elevated amounts in the serum of Alzheimer"s patients compared with healthy controls.	Iron	54-58	melanotransferrin	Homo sapiens	75-78
8849692-3	1996	Three antibodies, 2 IgG1 and 1 IgG2a, were found to bind both Fe(ToCPP) and the free base ToCPPH2 with similar binding constants.	Iron	62-64	immunoglobulin heavy variable V1-9	Mus musculus	31-36
8849692-10	1996	Both IgG1-Fe(ToCPP) complexes were found to catalyze the oxidation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) 5-fold more efficiently than Fe(ToCPP) alone whereas the binding of IgG2a to this iron-porphyrin had no effect on its catalytic activity.	Iron	10-12	immunoglobulin heavy variable V1-9	Mus musculus	199-204
8937637-4	1996	Antiserum to TfBP was found to stain selectively transferrin- and iron-rich oligodendrocytes of the normal chicken brain, suggesting a role for this protein in connection with transferrin and iron storage in these cells.	Iron	66-70	heat shock protein 90 beta family member 1	Gallus gallus	13-17
8937637-4	1996	Antiserum to TfBP was found to stain selectively transferrin- and iron-rich oligodendrocytes of the normal chicken brain, suggesting a role for this protein in connection with transferrin and iron storage in these cells.	Iron	192-196	heat shock protein 90 beta family member 1	Gallus gallus	13-17
8887268-10	1996	Our data thus indicate an important role of cytochrome P-450 in hydrogen peroxide-induced cytotoxicity to LLC-PK1 cells and suggest that cytochrome P-450 may serve as a source of catalytic iron.	Iron	189-193	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	44-60
8887268-10	1996	Our data thus indicate an important role of cytochrome P-450 in hydrogen peroxide-induced cytotoxicity to LLC-PK1 cells and suggest that cytochrome P-450 may serve as a source of catalytic iron.	Iron	189-193	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	137-153
8790155-0	1996	Parenteral iron increases serum erythropoietin concentration during the "early anaemia" of 10-20-day-old mice.	Iron	11-15	erythropoietin	Mus musculus	32-46
8790155-2	1996	In the present study we examined the effect of parenteral iron upon serum immunoreactive erythropoietin (siEpo) concentration in young mice (age 6-24d) and in adult iron-deficient mice.	Iron	58-62	erythropoietin	Mus musculus	89-103
8756349-3	1996	Ctr3p is a small intracellular cysteine-rich integral membrane protein that restores high-affinity Cu uptake, Cu, Zn superoxide dismutase activity, ferrous iron transport, and respiratory proficiency to strains lacking the CTR1 (Cu transporter 1) gene.	Iron	156-160	high-affinity Cu transporter CTR3	Saccharomyces cerevisiae S288C	0-5
8894739-1	1996	Aceruloplasminemia is a systemic degenerative disorder characterized by mutations in the ceruloplasmin gene, the absence of serum ceruloplasmin, and iron accumulation in the brain, liver, and other tissues.	Iron	149-153	ceruloplasmin	Homo sapiens	1-14
8660685-12	1996	These results indicate that the ability of NADH reductase and cytochrome b5 to interact with various ferric complexes depends on the nature of the chelating agent used to complex the iron and on the concentration of the iron.	Iron	183-187	cytochrome b5 type A	Homo sapiens	62-75
8660685-12	1996	These results indicate that the ability of NADH reductase and cytochrome b5 to interact with various ferric complexes depends on the nature of the chelating agent used to complex the iron and on the concentration of the iron.	Iron	220-224	cytochrome b5 type A	Homo sapiens	62-75
9983304-0	1996	Local properties at Fe and Co impurities in Nb1-xMox alloys.	Iron	20-22	CD177 molecule	Homo sapiens	44-47
8627283-2	1996	The results here reported: (i) allow the estimation, for the first time, of the ligand-independent free energy associated with the heme-iron sixth coordination bond in ferric and ferrous native cytochrome c, which turns out to be +8.4 kJ mol-1 and +14.6 kJ mol-1, at 25.0 degrees C, respectively, and (ii) suggest an interplay between redox, structural, ligand binding, and recognition properties of cytochrome c.	Iron	136-140	cytochrome c, somatic	Equus caballus	194-206
8627283-2	1996	The results here reported: (i) allow the estimation, for the first time, of the ligand-independent free energy associated with the heme-iron sixth coordination bond in ferric and ferrous native cytochrome c, which turns out to be +8.4 kJ mol-1 and +14.6 kJ mol-1, at 25.0 degrees C, respectively, and (ii) suggest an interplay between redox, structural, ligand binding, and recognition properties of cytochrome c.	Iron	136-140	cytochrome c, somatic	Equus caballus	400-412
8650873-1	1996	OBJECTIVES: Heme oxygenase isozymes, HO-1 and HO-2, are members of the stress/heat shock (HSP) family of proteins, with the known function of cleaving the heme molecule to biliverdin, iron, and carbon monoxide.	Iron	184-188	heme oxygenase 1	Homo sapiens	37-50
8650873-12	1996	CONCLUSIONS: The finding that HO-1 expression is increased in BPH and malignant prostate tissue is consistent with a role for this stress protein in the pathogenesis of BPH and prostate cancer; in the context of iron metabolism, an argument is made in support of this possibility.	Iron	212-216	heme oxygenase 1	Homo sapiens	30-34
8992201-0	1996	Ferritin effect on the transverse relaxation of water: NMR microscopy at 9.4 T. Accumulation of ferritin, the iron storage protein, has been linked recently to aging and a number of pathologies.	Iron	110-114	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	0-8
8992201-0	1996	Ferritin effect on the transverse relaxation of water: NMR microscopy at 9.4 T. Accumulation of ferritin, the iron storage protein, has been linked recently to aging and a number of pathologies.	Iron	110-114	ferritin, heavy polypeptide 1, gene 2 L homeolog	Xenopus laevis	96-104
8861201-7	1996	Cell-surface reductases, FRE1 and FRE2, provide ferrous iron for both systems.	Iron	56-60	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	34-38
8705293-4	1996	We have recently demonstrated that GPI-anchored MTf provides a novel route for cellular iron uptake which is independent of Tf and its receptor.	Iron	88-92	melanotransferrin	Homo sapiens	48-51
8705293-5	1996	Here we consider whether MTf may have a role in the transport of iron across the BBB.	Iron	65-69	melanotransferrin	Homo sapiens	25-28
8705293-9	1996	These data suggest that MTf may play a role in iron transport within the human brain.	Iron	47-51	melanotransferrin	Homo sapiens	24-27
8705294-3	1996	We have identified a novel pathway of iron uptake into mammalian cells involving melanotransferrin, or p97, which is independent of the transferrin receptor.	Iron	38-42	melanotransferrin	Homo sapiens	81-98
8705294-3	1996	We have identified a novel pathway of iron uptake into mammalian cells involving melanotransferrin, or p97, which is independent of the transferrin receptor.	Iron	38-42	melanotransferrin	Homo sapiens	103-106
8705294-8	1996	Our demonstration that melanotransferrin mediates iron uptake through a pathway independent of the transferrin receptor indicates that this mechanism may have a role in AD.	Iron	50-54	melanotransferrin	Homo sapiens	23-40
8622181-1	1996	In this study, it is shown that an electron from photoreduced tris(2,2"-bipyridyl)Ru2+ ion reaches the haem iron of engineered wild-type cytochrome P450 1A2 (P450 1A2) with an electron transfer rate of 6.04 x 10(-3) min(-1).	Iron	108-112	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	137-156
8547275-1	1996	His-25 and His-132 are the primary candidates for the proximal heme iron ligand in heme oxygenase isozyme-1 (HO-1).	Iron	68-72	heme oxygenase 1	Homo sapiens	83-107
8547275-1	1996	His-25 and His-132 are the primary candidates for the proximal heme iron ligand in heme oxygenase isozyme-1 (HO-1).	Iron	68-72	heme oxygenase 1	Homo sapiens	109-113
8558296-0	1996	Purified ferritin and soybean meal can be sources of iron for treating iron deficiency in rats.	Iron	53-57	ferritin-1, chloroplastic	Glycine max	9-17
8558296-6	1996	The combined data suggest that manipulating ferritin expression and other soluble components of seed iron in soybeans and possibly other seeds, using Mendelian and biotechnological approaches, could contribute to a sustainable solution to global problems of iron deficiency.	Iron	101-105	ferritin-1, chloroplastic	Glycine max	44-52
8560483-10	1996	On the other hand, cytosolic glutathione S-transferase (GST) activities with 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene (DCNB) as substrates, were also induced by the PCBs mixture, the induction with DCNB being synergistically potentiated by iron pretreatment.	Iron	259-263	hematopoietic prostaglandin D synthase	Mus musculus	29-54
8560483-10	1996	On the other hand, cytosolic glutathione S-transferase (GST) activities with 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene (DCNB) as substrates, were also induced by the PCBs mixture, the induction with DCNB being synergistically potentiated by iron pretreatment.	Iron	259-263	hematopoietic prostaglandin D synthase	Mus musculus	56-59
8560483-13	1996	The results illustrate that PCBs not only induce CYP1A1 in microsomes but also in the nuclear membrane, which may be of significance in the mechanism of the iron-enhanced carcinogenicity of these chemicals.	Iron	157-161	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-55
8560483-14	1996	The iron-enhanced induction of GST with accompanying depletion of glutathione peroxidase provides evidence for oxidative processes induced in vivo by the PCBs.	Iron	4-8	hematopoietic prostaglandin D synthase	Mus musculus	31-34
8530485-2	1995	The non-heme iron-dependent metalloenzyme, rat hepatic phenylalanine hydroxylase (EC 1.14.16.1; phenylalanine 4-monooxygenase (PAH) was overexpressed in Escherichia coli and purified to homogeneity, allowing a detailed comparison of the kinetic, hydrodynamic, and spectroscopic properties of its allosteric states.	Iron	13-17	phenylalanine hydroxylase	Rattus norvegicus	55-80
8745735-2	1995	We demonstrated that UAg is structurally and functionally related to proteins belonging to the transferrin family, as shown by amino acid sequence and iron binding experiments.	Iron	151-155	inhibitor of carbonic anhydrase	Canis lupus familiaris	95-106
7489724-0	1995	Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.	Iron	17-21	RNA binding motif single stranded interacting protein 3	Homo sapiens	51-70
8521861-4	1995	To assess the relevance of these findings to cellular pathology, peroxidation of myosin was performed with physiological divalent iron [Fe(II)] myoglobins in the oxy and deoxy forms.	Iron	130-134	myosin heavy chain 14	Homo sapiens	81-87
7656228-6	1995	Secondly, this study tested the effect of iron supplementation as a potential pro-oxidant in diets of varied fatty acid composition on PLA2 activity.	Iron	42-46	phospholipase A2	Zea mays	135-139
7794895-0	1995	Tyrosyl radical formation during the oxidative deposition of iron in human apoferritin.	Iron	61-65	ferritin heavy chain 1	Homo sapiens	75-86
7748897-6	1995	In the absence of the hydrogen-bonding interaction, Fe-bound imidazole in met-imidazole Dolabella myoglobin is only stable at neutral pH and is removed at acidic pH and replaced by OH- at basic pH.	Iron	52-54	myoglobin	Homo sapiens	98-107
7608597-9	1995	In the rEPO-treatment group, hematocrit levels remained unchanged and serum ferritin levels decreased significantly (p &lt; 0.02) after the donation; in addition, serum iron levels in the rEPO-treatment group decreased significantly (p &lt; 0.05) than those in the simple donation group during donation.	Iron	169-173	erythropoietin	Rattus norvegicus	7-11
7608597-9	1995	In the rEPO-treatment group, hematocrit levels remained unchanged and serum ferritin levels decreased significantly (p &lt; 0.02) after the donation; in addition, serum iron levels in the rEPO-treatment group decreased significantly (p &lt; 0.05) than those in the simple donation group during donation.	Iron	169-173	erythropoietin	Rattus norvegicus	188-192
7708681-8	1995	These findings support previous studies that identified ceruloplasmin as a ferroxidase and are remarkably consistent with recent studies on the essential role of a homologous copper oxidase in iron metabolism in yeast.	Iron	193-197	ceruloplasmin	Homo sapiens	56-69
7708696-6	1995	Instead, CCC2 mutant cells lacked a copper-dependent oxidase activity associated with the extracytosolic domain of the FET3-encoded protein, a ceruloplasmin homologue previously shown to be necessary for high-affinity iron uptake in yeast.	Iron	218-222	ceruloplasmin	Homo sapiens	143-156
7720713-6	1995	These effects may be explained by the failure of iron to repress transcription of FRE1, FRE2 and FET3.	Iron	49-53	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	88-92
7867079-0	1995	Iron differentially modulates the CD4-lck and CD8-lck complexes in resting peripheral blood T-lymphocytes.	Iron	0-4	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	38-41
7852847-4	1995	We now found that CK II is activated only when the cells are exposed to both IGF-1 and TF or when TF is replaced in this combination with relatively high levels of iron salts.	Iron	164-168	casein kinase 2 alpha 1	Homo sapiens	18-23
7662812-6	1995	The iron-saturated forms of human (S-hLf), bovine (S-bLf) lactoferrins and human transferrin (S-hTf) enhanced cell proliferation, while iron-unsaturated forms (U-hLf, U-bLf, and U-hTf) suppressed it.	Iron	4-8	HLF transcription factor, PAR bZIP family member	Homo sapiens	37-40
7662812-6	1995	The iron-saturated forms of human (S-hLf), bovine (S-bLf) lactoferrins and human transferrin (S-hTf) enhanced cell proliferation, while iron-unsaturated forms (U-hLf, U-bLf, and U-hTf) suppressed it.	Iron	4-8	HLF transcription factor, PAR bZIP family member	Homo sapiens	162-165
7947682-1	1994	The ferric iron-binding protein (Fbp) functions as a periplasmic-binding protein in the high-affinity active transport of growth-essential iron by pathogenic Neisseria.	Iron	11-15	folate receptor beta	Homo sapiens	33-36
7935843-2	1994	Single photons of visible light can break the covalent bond between CO and the haem iron in carbon-monoxy-myoglobin (MbCO) and thus form an unstable intermediate, Mb*CO, with the CO inside the protein.	Iron	84-88	myoglobin	Homo sapiens	106-115
7929136-5	1994	BH4, 7,8-dihydrobiopterin (BH2), 6-methyltetrahydropterin, and 5-deaza-6-methyltetrahydropterin were found to bind to unactivated phenylalanine hydroxylase with a stoichiometry of 1/enzyme subunit and with hyperbolic kinetics; all appear to compete for the same binding site on the enzyme, and all appear to bind in the proximity of, but not to, the enzyme"s non-heme iron.	Iron	368-372	phenylalanine hydroxylase	Rattus norvegicus	130-155
7836600-0	1994	Effect of twinning and supplemental iron-saturated lactoferrin on iron status of newborn calves.	Iron	36-40	lactotransferrin	Bos taurus	51-62
7836600-0	1994	Effect of twinning and supplemental iron-saturated lactoferrin on iron status of newborn calves.	Iron	66-70	lactotransferrin	Bos taurus	51-62
8093048-1	1994	Lactoferrin (LTF), which is the major iron-binding protein in milk and physiological fluids, belongs to the transferrin family.	Iron	38-42	lactotransferrin	Bos taurus	0-11
8093048-1	1994	Lactoferrin (LTF), which is the major iron-binding protein in milk and physiological fluids, belongs to the transferrin family.	Iron	38-42	lactotransferrin	Bos taurus	13-16
8093048-3	1994	Sequence comparisons reveal that structural features, including iron-binding sites, cysteine residues involved in disulphide bonds are remarkably conserved between LTF proteins from various species.	Iron	64-68	lactotransferrin	Bos taurus	164-167
8088060-5	1994	Nail involvement was associated with long-lasting symptoms related to osteoarthritis and high serum iron concentration.	Iron	100-104	CD244 molecule	Homo sapiens	0-4
7919137-4	1994	It was anticipated that repletion of iron stores with iv iron dextran would restore rEPO responsiveness, leading to a gradual rise in hematocrit to the target values (0.30 to 0.33).	Iron	37-41	erythropoietin	Rattus norvegicus	84-88
8025673-3	1994	During iron-limited growth mRNA levels for Tpi1p and Tdh3p were at least 3-fold lower than during iron-saturated growth; as shown with a hem1 mutant strain this regulation does not require haem synthesis.	Iron	7-11	5-aminolevulinate synthase	Saccharomyces cerevisiae S288C	137-141
8025673-3	1994	During iron-limited growth mRNA levels for Tpi1p and Tdh3p were at least 3-fold lower than during iron-saturated growth; as shown with a hem1 mutant strain this regulation does not require haem synthesis.	Iron	98-102	5-aminolevulinate synthase	Saccharomyces cerevisiae S288C	137-141
8191217-9	1994	Decreased CD8-p56lck activity was seen both in patients undergoing intensive phlebotomy treatment and in patients in maintenance therapy (i.e. patients who had reached normal levels of iron stores), indicating that this abnormality does not appear to be corrected by iron depletion.	Iron	185-189	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-20
8144581-4	1994	The interaction of 125I-LF-L and 125I-LF with RAGE was independent of iron in LF and was competed by addition of an excess of unlabeled carboxyl-terminal portion of LF.	Iron	70-74	lactotransferrin	Mus musculus	24-26
8144581-4	1994	The interaction of 125I-LF-L and 125I-LF with RAGE was independent of iron in LF and was competed by addition of an excess of unlabeled carboxyl-terminal portion of LF.	Iron	70-74	lactotransferrin	Mus musculus	38-40
8144581-4	1994	The interaction of 125I-LF-L and 125I-LF with RAGE was independent of iron in LF and was competed by addition of an excess of unlabeled carboxyl-terminal portion of LF.	Iron	70-74	lactotransferrin	Mus musculus	38-40
8144581-4	1994	The interaction of 125I-LF-L and 125I-LF with RAGE was independent of iron in LF and was competed by addition of an excess of unlabeled carboxyl-terminal portion of LF.	Iron	70-74	lactotransferrin	Mus musculus	38-40
8090582-3	1994	We suggest that the production of p97 by neoplastic cells of atypical adenomas and differentiated thyroid carcinomas could result in a greater availability of iron for tumor cell DNA synthesis.	Iron	159-163	melanotransferrin	Homo sapiens	34-37
8145237-9	1994	The results were that the amide nitrogen approaches relatively close to the heme iron in CYP1A1 (3.64 +/- 0.51 A) whereas it is significantly further away (&gt; 4.5 A) in CYP2B1.	Iron	81-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	89-95
8306995-9	1994	The detergent-solubilized protein transfers electrons from ETF to the ubiquinone homolog, Q1, indicating that both the FAD and iron-sulfur cluster are properly inserted into the heterologously expressed protein.	Iron	127-131	TEA domain transcription factor 2	Homo sapiens	59-62
8144019-1	1993	Iron metabolism parameters (increased level of serum ferritin, appearance of an iron pool specifically unrelated to transferrin, reduced ceruloplasmin level, etc.)	Iron	0-4	ceruloplasmin	Homo sapiens	137-150
8405472-0	1993	The reaction of ascorbic acid with different heme iron redox states of myoglobin.	Iron	50-54	myoglobin	Homo sapiens	71-80
8410355-2	1993	Consumption of excess dietary iron (3000, 5000, 8000 mg iron/kg/diet) compared with consumption of the control diet (120 mg iron/kg diet) by weanling male CD-1 mice for 7 wk resulted in accumulation of iron in liver, increased relative liver weights and a reduction in hepatic vitamin E stores.	Iron	30-34	CD1 antigen complex	Mus musculus	155-159
8410356-0	1993	Enhanced insulin-dependent glucose utilization in iron-deficient veal calves.	Iron	50-54	insulin	Bos taurus	9-16
7934822-4	1993	The results of this investigation provide evidence that Fbp participates in this process as a functional analogue of a Gram-negative periplasmic-binding protein component, which operates as a part of a general active transport process for the receptor-mediated, high-affinity transport of iron from human transferrin.	Iron	289-293	folate receptor beta	Homo sapiens	56-59
7934822-6	1993	Predictive of a periplasmic-binding protein, which functions in the high-affinity acquisition of iron, is that Fbp is a transient participant in the process of iron acquisition from human transferrin.	Iron	97-101	folate receptor beta	Homo sapiens	111-114
7934822-6	1993	Predictive of a periplasmic-binding protein, which functions in the high-affinity acquisition of iron, is that Fbp is a transient participant in the process of iron acquisition from human transferrin.	Iron	160-164	folate receptor beta	Homo sapiens	111-114
8214084-7	1993	Pretreatment of EC with the iron chelator deferoxamine mesylate (1-10 mM) for 4 h attenuated the PMN-mediated decrease in ACE activity, as did the thiol reducing agent, 2-mercaptoethanol (0.1 mM), and the myeloperoxidase inhibitor, cyanide (5 mM), but not azide (1-50 mM).	Iron	28-32	myeloperoxidase	Bos taurus	205-220
8251385-0	1993	Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site.	Iron	133-137	beaded filament structural protein 1	Rattus norvegicus	88-92
8251385-2	1993	CP94 was highly effective at mobilizing liver iron in rats but showed toxicity at higher doses, whereas in the guinea-pig the compound lacked toxicity but was ineffective at mobilizing liver iron.	Iron	46-50	beaded filament structural protein 1	Rattus norvegicus	0-4
8251385-13	1993	Whereas in guinea-pigs 99% of urinary recovery following an oral dose of CP94 (100 mg/kg) was as the inactive glucuronide metabolite, in the rat only 23% of the dose was excreted in the urine as the glucuronide with remainder as the free drug or an iron binding metabolite.	Iron	249-253	beaded filament structural protein 1	Rattus norvegicus	73-77
8313236-5	1993	This review focuses on the relationship between iron and copper with respect to the copper protein ceruloplasmin, which may play a role in iron homeostasis by catalyzing the oxidation of iron as it is placed in ferritin.	Iron	48-52	ceruloplasmin	Homo sapiens	99-112
8313236-5	1993	This review focuses on the relationship between iron and copper with respect to the copper protein ceruloplasmin, which may play a role in iron homeostasis by catalyzing the oxidation of iron as it is placed in ferritin.	Iron	139-143	ceruloplasmin	Homo sapiens	99-112
8313236-5	1993	This review focuses on the relationship between iron and copper with respect to the copper protein ceruloplasmin, which may play a role in iron homeostasis by catalyzing the oxidation of iron as it is placed in ferritin.	Iron	139-143	ceruloplasmin	Homo sapiens	99-112
8391992-0	1993	Oxidised low density lipoproteins induce iron release from activated myoglobin.	Iron	41-45	myoglobin	Homo sapiens	69-78
8391992-4	1993	This study provides evidence for a biochemical mechanism whereby iron is released from myoglobin by low density lipoprotein (LDL) which has become oxidised by the ferryl myoglobin species.	Iron	65-69	myoglobin	Homo sapiens	87-96
8391992-4	1993	This study provides evidence for a biochemical mechanism whereby iron is released from myoglobin by low density lipoprotein (LDL) which has become oxidised by the ferryl myoglobin species.	Iron	65-69	myoglobin	Homo sapiens	170-179
8391992-6	1993	Thus, iron may derive from the myoglobin released from ruptured cells in the oxidising environment of the atherosclerotic lesion.	Iron	6-10	myoglobin	Homo sapiens	31-40
8345124-0	1993	Iron-binding properties of bovine lactoferrin in iron-rich solution.	Iron	49-53	lactotransferrin	Bos taurus	34-45
8345124-1	1993	The iron-binding properties of bovine lactoferrin in iron-rich solution were investigated.	Iron	4-8	lactotransferrin	Bos taurus	38-49
8345124-1	1993	The iron-binding properties of bovine lactoferrin in iron-rich solution were investigated.	Iron	53-57	lactotransferrin	Bos taurus	38-49
8345124-2	1993	Ferrous iron was not stable in solution and was easily changed to the insoluble ferric state, but solubility of ferrous iron was stabilized by the presence of lactoferrin.	Iron	112-124	lactotransferrin	Bos taurus	159-170
8345124-4	1993	As indicated by use of cibacron blue affinity gel, iron bound to lactoferrin, and the charge of supersaturated lactoferrin was higher than that of normal iron-saturated lactoferrin according to native PAGE electrophoresis.	Iron	51-55	lactotransferrin	Bos taurus	65-76
7687131-0	1993	Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo.	Iron	118-122	catechol-O-methyltransferase	Rattus norvegicus	14-42
7687131-0	1993	Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo.	Iron	118-122	catechol-O-methyltransferase	Rattus norvegicus	44-48
8083500-1	1993	Transferrin receptors (TfR"s) on the syncytiotrophoblast mediate transferrin (Tf) dependent Fe uptake and transfer to the fetus.	Iron	92-94	inhibitor of carbonic anhydrase	Cavia porcellus	0-11
8083500-1	1993	Transferrin receptors (TfR"s) on the syncytiotrophoblast mediate transferrin (Tf) dependent Fe uptake and transfer to the fetus.	Iron	92-94	inhibitor of carbonic anhydrase	Cavia porcellus	65-76
8083500-1	1993	Transferrin receptors (TfR"s) on the syncytiotrophoblast mediate transferrin (Tf) dependent Fe uptake and transfer to the fetus.	Iron	92-94	inhibitor of carbonic anhydrase	Cavia porcellus	23-25
8385904-2	1993	Hepatocytes exposed to IFN-gamma, TNF-alpha, IL-1 beta, and LPS demonstrated the appearance of a g = 2.04 axial EPR signal indicative of the formation of nonheme iron-nitrosyl complexes.	Iron	162-166	interferon gamma	Rattus norvegicus	23-32
8094645-2	1993	The reaction required iron, iron chelators and oxygen, was accelerated by glycylglycine (gly)2, a GGT enhancer, and was inhibited by the GGT inhibitors serine--borate and acivicin.	Iron	22-26	gamma-glutamyltransferase 1	Rattus norvegicus	98-101
8094645-2	1993	The reaction required iron, iron chelators and oxygen, was accelerated by glycylglycine (gly)2, a GGT enhancer, and was inhibited by the GGT inhibitors serine--borate and acivicin.	Iron	22-26	gamma-glutamyltransferase 1	Rattus norvegicus	137-140
8094645-2	1993	The reaction required iron, iron chelators and oxygen, was accelerated by glycylglycine (gly)2, a GGT enhancer, and was inhibited by the GGT inhibitors serine--borate and acivicin.	Iron	28-32	gamma-glutamyltransferase 1	Rattus norvegicus	98-101
8094645-2	1993	The reaction required iron, iron chelators and oxygen, was accelerated by glycylglycine (gly)2, a GGT enhancer, and was inhibited by the GGT inhibitors serine--borate and acivicin.	Iron	28-32	gamma-glutamyltransferase 1	Rattus norvegicus	137-140
8430794-0	1993	Lactoferrin interferes with uptake of iron from transferrin and asialotransferrin by the rat liver.	Iron	38-42	lactotransferrin	Rattus norvegicus	0-11
8430794-1	1993	Intravenous injection of bovine or human lactoferrin (6.25 x 10(-2) mumol/100 g body wt) in rats resulted in marked reduction of hepatic iron uptake from transferrin and asialotransferrin.	Iron	137-141	lactotransferrin	Rattus norvegicus	41-52
8430794-9	1993	The data obtained are compatible with the hypothesis that lactoferrin and other proteins with similarly high affinity for hepatic heparan sulfate exert their negative effect on iron uptake by preventing transferrin binding to the proteoglycan.	Iron	177-181	lactotransferrin	Rattus norvegicus	58-69
1459415-1	1992	Bovine lactoferrin is an iron-binding protein present in mammary gland secretions.	Iron	25-29	lactotransferrin	Bos taurus	7-18
1445388-0	1992	Polymeric ovotransferrin and its ability to bind and deliver iron to chick-embryo red blood cells.	Iron	61-65	transferrin (ovotransferrin)	Gallus gallus	10-24
1644822-15	1992	The concomitant regulation of gene expression of MT-1 and HO in response to heme-hemopexin appears to be a concerted adaptive response of the cells, mediated at the level of the plasma membrane hemopexin receptor, and may relate to the proposed role of MT as an intracellular antioxidant or to a need to sequester zinc which otherwise would compete with iron and occupy sites on regulatory proteins such as the iron-responsive elements.	Iron	354-358	metallothionein 1I, pseudogene	Homo sapiens	49-60
1644822-15	1992	The concomitant regulation of gene expression of MT-1 and HO in response to heme-hemopexin appears to be a concerted adaptive response of the cells, mediated at the level of the plasma membrane hemopexin receptor, and may relate to the proposed role of MT as an intracellular antioxidant or to a need to sequester zinc which otherwise would compete with iron and occupy sites on regulatory proteins such as the iron-responsive elements.	Iron	354-358	hemopexin	Mus musculus	194-203
1644822-15	1992	The concomitant regulation of gene expression of MT-1 and HO in response to heme-hemopexin appears to be a concerted adaptive response of the cells, mediated at the level of the plasma membrane hemopexin receptor, and may relate to the proposed role of MT as an intracellular antioxidant or to a need to sequester zinc which otherwise would compete with iron and occupy sites on regulatory proteins such as the iron-responsive elements.	Iron	411-415	metallothionein 1I, pseudogene	Homo sapiens	49-60
1644822-15	1992	The concomitant regulation of gene expression of MT-1 and HO in response to heme-hemopexin appears to be a concerted adaptive response of the cells, mediated at the level of the plasma membrane hemopexin receptor, and may relate to the proposed role of MT as an intracellular antioxidant or to a need to sequester zinc which otherwise would compete with iron and occupy sites on regulatory proteins such as the iron-responsive elements.	Iron	411-415	hemopexin	Mus musculus	194-203
1321591-7	1992	Using 17O-enriched water, we show conclusively that nucleophilic addition of water occurs at the nitrone carbon (or C-2 position) of DMPO in the presence of either Fe or Cu ions.	Iron	164-166	complement C2	Homo sapiens	116-119
1641779-11	1992	Failure to provide iron supplementation in patients receiving rEPO can lead to a rapid depletion of iron stores and may contribute to an immune dysfunction.	Iron	19-23	erythropoietin	Rattus norvegicus	62-66
1641779-11	1992	Failure to provide iron supplementation in patients receiving rEPO can lead to a rapid depletion of iron stores and may contribute to an immune dysfunction.	Iron	100-104	erythropoietin	Rattus norvegicus	62-66
1623608-1	1992	We developed a direct, simple, and sensitive procedure for the simultaneous colorimetric assay of iron and copper in serum, using sodium dodecyl sulfate-ascorbic acid to dissociate iron and copper from transferrin and ceruloplasmin, respectively.	Iron	98-102	ceruloplasmin	Homo sapiens	218-231
1628642-5	1992	The availability of recently developed host cells that simultaneously overexpress yeast NADPH-P450 reductase and/or express human liver cytochrome b5, obtained through stable integration of the corresponding coding sequences into the yeast genome, led to biotechnological systems with much higher activities of yeast-expressed P450 NF25 and with much better ability to form P450 NF25-iron-metabolite complexes.	Iron	384-388	cytochrome b5 type A	Homo sapiens	136-149
1392356-13	1992	These observations favour the idea that lactoferrin may be involved in iron absorption.	Iron	71-75	lactotransferrin	Bos taurus	40-51
1599934-1	1992	We report the existence of a previously unknown antimicrobial domain near the N-terminus of lactoferrin in a region distinct from its iron-binding sites.	Iron	134-138	lactotransferrin	Bos taurus	92-103
1353023-5	1992	Modelling of Fe(III) dimer binding to human H chain apoferritin shows a solvent-accessible site, which resembles that of ribonucleotide reductase in its ligands.	Iron	13-15	ferritin heavy chain 1	Homo sapiens	52-63
1576990-1	1992	A high-pressure Fourier-transform infrared technique was used to probe the evolution of 2H bonds inside the helical segments of myoglobin in relation to p2H, Tris concentration in the medium and iron-ligand nature.	Iron	195-199	myoglobin	Homo sapiens	128-137
1611871-7	1992	Iron ions bound to lactoferrin affected the profiles of induced Cotton effects in human lactoferrin but not in bovine lactoferrin.	Iron	0-4	lactotransferrin	Bos taurus	19-30
1611871-7	1992	Iron ions bound to lactoferrin affected the profiles of induced Cotton effects in human lactoferrin but not in bovine lactoferrin.	Iron	0-4	lactotransferrin	Bos taurus	88-99
1611871-7	1992	Iron ions bound to lactoferrin affected the profiles of induced Cotton effects in human lactoferrin but not in bovine lactoferrin.	Iron	0-4	lactotransferrin	Bos taurus	88-99
1313286-0	1992	Xanthine dehydrogenase from Drosophila melanogaster: purification and properties of the wild-type enzyme and of a variant lacking iron-sulfur centers.	Iron	130-134	rosy	Drosophila melanogaster	0-22
1313286-1	1992	Xanthine dehydrogenase has been purified to homogeneity by conventional procedures from the wild-type strain of the fruit fly Drosophila melanogaster, as well as from a rosy mutant strain (E89----K, ry5231) known to carry a point mutation in the iron-sulfur domain of the enzyme.	Iron	246-250	rosy	Drosophila melanogaster	0-22
1616493-4	1992	The latter aggregates are suggested to result from pairing of myosin radicals formed by the H2O2 induced ferryl iron state in myoglobin, free hemin or hemo-myosin.	Iron	112-116	myosin heavy chain 14	Homo sapiens	62-68
1381615-3	1992	EDRF is suggested to be a nitrosyl complex of iron with low-molecular thiol-containing ligands, most probably with cysteine.	Iron	46-50	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
1581551-5	1992	Defensive mechanisms against iron overload are exhibited by most cell lines and include: (1) the capacity of synthesis of the protein apoferritin by most cells whenever the concentration of ambient iron increases, (2) the capacity to bind toxic inorganic iron within the hollow shell of apoferritin; the transfer of the assembled iron-rich ferritin molecules into siderosomes and (3) the capability of further iron segregation within siderosomes by degradation of ferritin to hemosiderin.	Iron	29-33	ferritin heavy chain 1	Homo sapiens	134-145
1581551-5	1992	Defensive mechanisms against iron overload are exhibited by most cell lines and include: (1) the capacity of synthesis of the protein apoferritin by most cells whenever the concentration of ambient iron increases, (2) the capacity to bind toxic inorganic iron within the hollow shell of apoferritin; the transfer of the assembled iron-rich ferritin molecules into siderosomes and (3) the capability of further iron segregation within siderosomes by degradation of ferritin to hemosiderin.	Iron	29-33	ferritin heavy chain 1	Homo sapiens	287-298
1581551-5	1992	Defensive mechanisms against iron overload are exhibited by most cell lines and include: (1) the capacity of synthesis of the protein apoferritin by most cells whenever the concentration of ambient iron increases, (2) the capacity to bind toxic inorganic iron within the hollow shell of apoferritin; the transfer of the assembled iron-rich ferritin molecules into siderosomes and (3) the capability of further iron segregation within siderosomes by degradation of ferritin to hemosiderin.	Iron	198-202	ferritin heavy chain 1	Homo sapiens	134-145
1581551-5	1992	Defensive mechanisms against iron overload are exhibited by most cell lines and include: (1) the capacity of synthesis of the protein apoferritin by most cells whenever the concentration of ambient iron increases, (2) the capacity to bind toxic inorganic iron within the hollow shell of apoferritin; the transfer of the assembled iron-rich ferritin molecules into siderosomes and (3) the capability of further iron segregation within siderosomes by degradation of ferritin to hemosiderin.	Iron	198-202	ferritin heavy chain 1	Homo sapiens	134-145
1581551-5	1992	Defensive mechanisms against iron overload are exhibited by most cell lines and include: (1) the capacity of synthesis of the protein apoferritin by most cells whenever the concentration of ambient iron increases, (2) the capacity to bind toxic inorganic iron within the hollow shell of apoferritin; the transfer of the assembled iron-rich ferritin molecules into siderosomes and (3) the capability of further iron segregation within siderosomes by degradation of ferritin to hemosiderin.	Iron	198-202	ferritin heavy chain 1	Homo sapiens	134-145
1581551-5	1992	Defensive mechanisms against iron overload are exhibited by most cell lines and include: (1) the capacity of synthesis of the protein apoferritin by most cells whenever the concentration of ambient iron increases, (2) the capacity to bind toxic inorganic iron within the hollow shell of apoferritin; the transfer of the assembled iron-rich ferritin molecules into siderosomes and (3) the capability of further iron segregation within siderosomes by degradation of ferritin to hemosiderin.	Iron	198-202	ferritin heavy chain 1	Homo sapiens	134-145
1661314-3	1991	Accordingly, we examined the possibility that uptake of iron-free (apo) lactoferrin by human mononuclear phagocytes could play a role in limiting the potential for generation of hydroxyl radical during the monocyte/MDM respiratory burst.	Iron	56-60	secreted LY6/PLAUR domain containing 1	Homo sapiens	215-218
1771947-5	1991	There was a significant correlation of faecal alpha-1-antitrypsin with CDAI, activity index van Hees, and with various laboratory parameters (ESR, CRP, serum alpha-1-antitrypsin, orosomucoid, albumin, iron, haematocrit, haemoglobin, leucocytes, and thrombocytes).	Iron	201-205	adrenoceptor alpha 1D	Homo sapiens	46-53
1668610-3	1991	In a model system, addition of iron compounds to normal ghosts showed that free heme, hemoglobin, Fe/adenosine diphosphate (ADP), and ferritin all catalyze .OH production; concurrent inhibition studies using DF documented that the unchelatable Fenton component is free heme or hemoglobin.	Iron	31-35	WD and tetratricopeptide repeats 1	Homo sapiens	98-129
1909571-11	1991	The NQO2 subunit is homologous to the Mr 24,000 subunit of the mammalian mitochondrial NADH-ubiquinone oxidoreductase which bears an electron paramagnetic resonance-visible binuclear iron-sulfur cluster (probably cluster N1b).	Iron	183-187	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	4-8
1909571-12	1991	Comparison of the predicted amino acid sequence of the Paracoccus NQO2 subunit with those of its mammalian counterparts suggests putative binding sites for the iron-sulfur cluster.	Iron	160-164	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	66-70
2065651-4	1991	The enzyme expressed in the oocytes under the direction of plant RNA is indistinguishable from genuine plant EFE with regard to its saturation kinetics, its iron dependency and its stereospecificity to the diastereomeric ethyl derivatives of ACC, allocoronamic acid and coronamic acid.	Iron	157-161	1-aminocyclopropane-1-carboxylate oxidase 4	Solanum lycopersicum	109-112
2065674-0	1991	Uptake of iron by apoferritin from a ferric dihydrolipoate complex.	Iron	10-14	ferritin heavy chain 1	Homo sapiens	18-29
2065674-2	1991	The ferric dihydrolipoate complex was chemically synthesized and used as an iron donor to apoferritin.	Iron	76-80	ferritin heavy chain 1	Homo sapiens	90-101
2065674-3	1991	Iron uptake was studied, at slightly alkaline pH and in anaerobic conditions, as a function of the concentration of both the iron donor and apoferritin.	Iron	0-4	ferritin heavy chain 1	Homo sapiens	140-151
2007131-0	1991	Role of phosphate in initial iron deposition in apoferritin.	Iron	29-33	ferritin heavy chain 1	Homo sapiens	48-59
2007131-3	1991	The influence of phosphate on the initial deposition of iron in apoferritin (12 Fe/protein) was investigated by EPR, 57Fe Mossbauer spectroscopy, and equilibrium dialysis.	Iron	56-60	ferritin heavy chain 1	Homo sapiens	64-75
2007131-5	1991	The presence of 1 mM phosphate during reconstitution of ferritin from apoferritin, Fe(II), and O2 accelerates the rate of oxidation of the iron 2-fold at pH 7.5.	Iron	139-143	ferritin heavy chain 1	Homo sapiens	70-81
2042339-2	1991	It was established that ceruloplasmin was well tolerated by the patients and its use during polychemotherapy is accompanied by normalization of the levels of natural ceruloplasmin and iron in the blood serum that are usually reduced in patients with gastric cancer, reduces activation of lipid peroxidation and improves the course of postoperative period.	Iron	184-188	ceruloplasmin	Homo sapiens	24-37
2001412-1	1991	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	39-56
2001412-1	1991	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	58-61
2001412-8	1991	A membrane-bound, iron-binding component with properties consistent with melanotransferrin was observed.	Iron	18-22	melanotransferrin	Homo sapiens	73-90
2035305-0	1991	Iron availability from an infant formula supplemented with bovine lactoferrin.	Iron	0-4	lactotransferrin	Bos taurus	66-77
2035305-4	1991	The lactoferrin supplemented group received 169 micrograms iron/kg b.w.	Iron	59-63	lactotransferrin	Bos taurus	4-15
1649082-5	1991	The effects of CP on iron-catalyzed lipid peroxidation in systems containing exogenously added ferrous iron was also investigated.	Iron	21-25	ceruloplasmin	Homo sapiens	15-17
1649082-9	1991	Collectively these data suggest that CP inhibits superoxide and ferritin-dependent lipid peroxidation via its ability to incorporate reductively-mobilized iron into ferritin.	Iron	155-159	ceruloplasmin	Homo sapiens	37-39
1846124-5	1991	The 50% lethal dose of cytolysin-negative strains was comparable to that of the cytolysin-positive parent strains after intraperitoneal inoculation with and without iron loading.	Iron	165-169	perforin 1 (pore forming protein)	Mus musculus	23-32
1763410-0	1991	Acute effects of T-2 toxin on radioactive iron incorporation into circulating erythrocytes in mice.	Iron	42-46	brachyury 2	Mus musculus	17-20
2271662-7	1990	The remaining iron sites, Feb1,2,3, show minor changes when substrate is bound.	Iron	14-18	FEB1	Homo sapiens	26-34
2289051-0	1990	Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated rats.	Iron	88-92	coproporphyrinogen oxidase	Rattus norvegicus	0-26
2289051-1	1990	The activities of coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase in liver homogenates of iron-overloaded and acutely or chronically ethanol-treated rats were assayed by high performance liquid chromatographic methods.	Iron	116-120	coproporphyrinogen oxidase	Rattus norvegicus	18-44
2289051-2	1990	Decreased coproporphyrinogen oxidase activity was found in chronically carbonyliron-fed rats while the activities of protoporphyrinogen oxidase and ferrochelatase remained unchanged.	Iron	71-83	coproporphyrinogen oxidase	Rattus norvegicus	10-36
2355932-0	1990	Iron-supplemented bovine serum as an alternative to fetal bovine serum in the CHO/HGPRT mutation assay.	Iron	0-4	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	82-87
2355932-1	1990	Iron-supplemented bovine calf serum (ICS) was found to be a viable alternative to fetal bovine serum (FBS) in the growth promotion and cloning efficiency of Chinese hamster ovary (CHO) cells that are used in the HGPRT mutation assay.	Iron	0-4	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	212-217
2191491-6	1990	Ceruloplasmin represents the molecular link between copper and iron metabolism.	Iron	63-67	ceruloplasmin	Homo sapiens	0-13
2247677-9	1990	Iron stores and blood pressure in hypertensive patients on treatment with EPO-R must be monitored regularly.	Iron	0-4	erythropoietin receptor	Homo sapiens	74-79
1970026-1	1990	To test the hypothesis that iron overload induces free radical damage in rhesus haemolytic disease (RHD), cord blood plasma of babies with RHD was compared with that of controls matched for gestational age.	Iron	28-32	Rh blood group D antigen	Homo sapiens	100-103
1970026-2	1990	Babies with RHD had higher ferritin levels, lower latent iron-binding capacity, increased concentrations of lipid-peroxidation products, and low vitamin C levels.	Iron	57-61	Rh blood group D antigen	Homo sapiens	12-15
1970026-4	1990	These findings, of iron overload and free radical damage, have implications for treatment of RHD.	Iron	19-23	Rh blood group D antigen	Homo sapiens	93-96
1690354-5	1990	We now report that treatment of endothelial cells (EC) with modified low-density lipoproteins obtained by mild iron oxidation or by prolonged storage, results in a rapid and large induction of the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage CSF (M-CSF) and granulocyte CSF (G-CSF).	Iron	111-115	colony stimulating factor 2	Homo sapiens	211-259
2310509-6	1990	The analytical technique of immobilized metal ion affinity chromatography also shows great promise in the purification of apoferritin, ferritin, and other iron-binding proteins.	Iron	155-159	ferritin heavy chain 1	Homo sapiens	122-133
2347653-0	1990	Iron metabolism under rEPO therapy in patients on maintenance hemodialysis.	Iron	0-4	erythropoietin	Rattus norvegicus	22-26
2347653-10	1990	It thus appears that iron demand rises markedly during rEPO therapy, requiring iron substitution in most patients.	Iron	21-25	erythropoietin	Rattus norvegicus	55-59
2314947-0	1990	Iron retention from lactoferrin-supplemented formulas in infant rhesus monkeys.	Iron	0-4	lactotransferrin	Bos taurus	20-31
2341289-1	1990	A comparative study of carrier-free 67Ga-citrate uptake by Ehrlich ascites tumor cells in the presence of lactoferrin, transferrin and ferritin has demonstrated that lactoferrin considerably increases the uptake of 67Ga, and that this increase seems to be determined by its iron-load.	Iron	274-278	lactotransferrin	Mus musculus	166-177
33974312-0	2021	Editorial for "Serum Ceruloplasmin Depletion is Associated With the Widespread Accumulation of Brain Iron in Parkinson"s Disease".	Iron	101-105	ceruloplasmin	Homo sapiens	21-34
33802993-6	2021	Furthermore, exposure to relatively non-toxic Fe@CeO2 NPs, but not the toxic Cr@CeO2 NPs, resulted in increased binding of MLL1 complex, a major histone lysine methylase mediating trimethylation of histone H3 lysine 4, at the NRF2 promoter.	Iron	46-48	lysine methyltransferase 2A	Homo sapiens	123-127
33804125-1	2021	Heme oxygenase-1 (HO-1) plays a vital role in the catabolism of heme and yields equimolar amounts of biliverdin, carbon monoxide, and free iron.	Iron	139-143	heme oxygenase 1	Homo sapiens	0-16
33804125-1	2021	Heme oxygenase-1 (HO-1) plays a vital role in the catabolism of heme and yields equimolar amounts of biliverdin, carbon monoxide, and free iron.	Iron	139-143	heme oxygenase 1	Homo sapiens	18-22
33803317-5	2021	Heme oxygenase-1 (HO-1) is an iron-dependent cytoprotective enzyme that functions as the inducible form of HO.	Iron	30-34	heme oxygenase 1	Homo sapiens	0-16
33803317-5	2021	Heme oxygenase-1 (HO-1) is an iron-dependent cytoprotective enzyme that functions as the inducible form of HO.	Iron	30-34	heme oxygenase 1	Homo sapiens	18-22
33817543-11	2021	In most subjects, hepcidin concentrations increased following iron ingestion (overall group mean = 4.98 +- 0.98 ng/mL at 5 h, P < 0.001), but double heterozygotes at rs2235321 and rs855791 showed no increase (0.36 +- 0.40 ng/mL at 5 h, P = 0.667).	Iron	62-66	hepcidin antimicrobial peptide	Homo sapiens	18-26
28452831-15	2018	The elevated hepcidin levels may affect the iron balance of the athletes, adding to the traditional explanation of dietary intake/iron loss balance.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	13-21
28452831-15	2018	The elevated hepcidin levels may affect the iron balance of the athletes, adding to the traditional explanation of dietary intake/iron loss balance.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	13-21
29289017-1	2018	SM1, a novel iron-reducing and uranium-precipitating strain.	Iron	13-17	SM1	Homo sapiens	0-3
29289017-6	2018	SM1, was also able to dissimilatory reduce iron (III) and uranium (VI) in the presence of citrate as an electron donor.	Iron	43-47	SM1	Homo sapiens	0-3
29136618-0	2017	Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus Patients.	Iron	12-16	hepcidin antimicrobial peptide	Homo sapiens	0-8
29136618-4	2017	The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	44-52
29136618-6	2017	However, inappropriate production of hepcidin has been shown to play a role in the pathogenesis of type 2 diabetes mellitus and its complications, based on the regulation and expression in iron-abundant cells.	Iron	189-193	hepcidin antimicrobial peptide	Homo sapiens	37-45
29136618-7	2017	Underexpression of hepcidin results in body iron overload, which triggers the production of reactive oxygen species simultaneously thought to play a major role in diabetes pathogenesis mediated both by beta-cell failure and insulin resistance.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	19-27
26323600-5	2015	However, higher free iron uptake activity was detected in the MSN5-deletion mutant.	Iron	21-25	karyopherin MSN5	Saccharomyces cerevisiae S288C	62-66
26358513-1	2015	BMP-SMAD signalling plays a crucial role in numerous biological processes including embryonic development and iron homeostasis.	Iron	110-114	bone morphogenetic protein 1	Homo sapiens	0-3
26358513-2	2015	Dysregulation of the iron-regulatory hormone hepcidin is associated with many clinical iron-related disorders.	Iron	21-25	hepcidin antimicrobial peptide	Homo sapiens	45-53
26358513-3	2015	We hypothesised that molecules which mediate BMP-SMAD signalling play important roles in the regulation of iron homeostasis and variants in these proteins may be potential genetic modifiers of iron-related diseases.	Iron	107-111	bone morphogenetic protein 1	Homo sapiens	45-48
26358513-3	2015	We hypothesised that molecules which mediate BMP-SMAD signalling play important roles in the regulation of iron homeostasis and variants in these proteins may be potential genetic modifiers of iron-related diseases.	Iron	193-197	bone morphogenetic protein 1	Homo sapiens	45-48
26358513-7	2015	In conclusion, we have identified a hitherto unrecognised link, endofin, between the BMP-SMAD signalling pathway, and the regulation of hepcidin expression and iron homeostasis.	Iron	160-164	bone morphogenetic protein 1	Homo sapiens	85-88
23123528-2	2012	Our understanding of the molecular control of iron metabolism has increased dramatically over the past 10 years due to the discovery of hepcidin, which regulates the uptake of dietary iron and its mobilization from macrophages and hepatic stores.	Iron	46-50	hepcidin antimicrobial peptide	Homo sapiens	136-144
23123528-2	2012	Our understanding of the molecular control of iron metabolism has increased dramatically over the past 10 years due to the discovery of hepcidin, which regulates the uptake of dietary iron and its mobilization from macrophages and hepatic stores.	Iron	184-188	hepcidin antimicrobial peptide	Homo sapiens	136-144
14623105-1	2003	The Fet3 protein in Saccharomyces cerevisiae and mammalian ceruloplasmin are multicopper oxidases (MCO) that are required for iron homeostasis via their catalysis of the ferroxidase reaction, 4Fe(2+)+O(2)+4H(+)--&gt;4Fe(3+)+2H(2)O.	Iron	126-130	ceruloplasmin	Homo sapiens	59-72
34896255-4	2022	When iron atoms are removed apoferritin (AFt) is formed which consists of a hollow shell where it can be used to load guest molecules.	Iron	5-9	ferritin heavy chain 1	Homo sapiens	28-39
34896255-4	2022	When iron atoms are removed apoferritin (AFt) is formed which consists of a hollow shell where it can be used to load guest molecules.	Iron	5-9	ferritin heavy chain 1	Homo sapiens	41-44
34626672-0	2022	Do Extremely Low Gestational Age Neonates Regulate Iron Absorption via Hepcidin?	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	71-79
34626672-1	2022	OBJECTIVES: To evaluate whether extremely preterm infants regulate iron status via hepcidin.	Iron	67-71	hepcidin antimicrobial peptide	Homo sapiens	83-91
34953963-5	2022	Taken together, our data suggest that activation of VDR could inhibit the phosphorylations of Tau possibly by repressing the iron accumulation-induced upregulation of GSK3beta activity in the brains of APP/PS1 mice.	Iron	125-129	presenilin 1	Mus musculus	206-209
34626772-8	2022	Although GPX4 protected UVB-injured keratinocytes against ferroptotic cell death resulted from dysregulation of iron metabolism and the subsequent increase of lipid ROS, keratinocytes enduring constant UVB treatment were markedly sensitized to ferroptosis.	Iron	112-116	glutathione peroxidase 4	Mus musculus	9-13
34826424-7	2022	In addition, we demonstrated significant FTH1 expression in normal lung cells when compared to lung cancer cells, which prevented iron from playing a role in increasing IR-induced cell death.	Iron	130-134	ferritin heavy chain 1	Homo sapiens	41-45
34939417-4	2021	These nanoprobes utilize apoferritin (an intracellular protein for iron stores and release) to encase appropriate molecular organic dyes to produce on-demand fluorescence in aqueous solution.	Iron	67-71	ferritin heavy chain 1	Homo sapiens	25-36
34704324-3	2021	Fe single atoms dispersed in hierarchically porous N-doped carbon matrix with high metal content (2.78 wt.%) and configuration of FeN4Cl1 (FeN4Cl1/NC) as well as mesopores with proportion of 0.92 (pore-volume ration) were obtained via the pyrolysis of a Zn/Fe-bimetallic MET modified with 4,5-dichloroimidazole.	Iron	0-2	SAFB like transcription modulator	Homo sapiens	271-274
34843649-5	2021	Crystallographic studies with the JmjC demethylase KDM5B revealed active site binding but without direct metal chelation; however, molecular modeling investigations indicated that the inhibitors bind to MINA53 by directly interacting with the iron cofactor.	Iron	243-247	ribosomal oxygenase 2	Homo sapiens	203-209
34870559-1	2021	Hepcidin is a principal regulator of iron homeostasis and its dysregulation has been recognised as a causative factor in cancers and iron disorders.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	0-8
34786942-2	2021	Herein, MoS2@PDA-Fe@PEG/TPP (MPFPT) nanosheets (NSs) with mitochondria-targeting ability were reported for enhanced PTT-CDT synergistic oncotherapy.	Iron	17-19	mago homolog, exon junction complex core component	Mus musculus	8-12
34615436-1	2021	Solute carrier family 39, member 1 (SLC39A1) is a member of the zinc-iron permease family and located to the cell membrane, acting as a zinc uptake transporter.	Iron	69-73	solute carrier family 39 member 1	Homo sapiens	0-34
34615436-1	2021	Solute carrier family 39, member 1 (SLC39A1) is a member of the zinc-iron permease family and located to the cell membrane, acting as a zinc uptake transporter.	Iron	69-73	solute carrier family 39 member 1	Homo sapiens	36-43
34592245-10	2021	Klotho significantly prevented ferroptosis and iron overload.	Iron	47-51	Klotho	Rattus norvegicus	0-6
34592245-11	2021	Meanwhile, klotho regulated the expressions of divalent metal transporter 1 (DMT 1) and ferroportin (FPN) that were associated with iron accumulation in the hippocampus.	Iron	132-136	Klotho	Rattus norvegicus	11-17
34571083-4	2021	miR-5096-induced ferroptotic cell death in human breast cancer cells was confirmed by concurrently increased ROS, OH-, lipid ROS, and iron accumulation levels and decreased GSH and mitochondrial membrane potential (MitoTracker  Orange) with mitochondrial shrinkage and partial cristae loss (observed by TEM).	Iron	134-138	microRNA 5096	Homo sapiens	0-8
34571083-6	2021	Ectopic expression of SLC7A11 partly reversed miR-5096-mediated effects on cell survival, ROS, lipid peroxides, iron accumulation, GSH, hydroxyl radicals, mitochondrial membrane potential, and colony formation.	Iron	112-116	solute carrier family 7 member 11	Homo sapiens	22-29
34571083-6	2021	Ectopic expression of SLC7A11 partly reversed miR-5096-mediated effects on cell survival, ROS, lipid peroxides, iron accumulation, GSH, hydroxyl radicals, mitochondrial membrane potential, and colony formation.	Iron	112-116	microRNA 5096	Homo sapiens	46-54
34755647-3	2021	The liver synthesized peptide hormone hepcidin is a master regulator of systemic iron metabolism.	Iron	81-85	hepcidin antimicrobial peptide	Homo sapiens	38-46
34148165-1	2021	Hepcidin is an iron metabolism inhibitor that increases with chronic inflammation.	Iron	15-19	hepcidin antimicrobial peptide	Homo sapiens	0-8
34148165-15	2021	Key Points   Hepcidin, an iron metabolism inhibitor in chronic inflammation, increases during the acute phase of Kawasaki disease.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	13-21
34460113-11	2021	These results indicate that Fth iron storage in astrocytes is vital for early oligodendrocyte development as well as for the remyelination of the CNS.	Iron	32-36	ferritin heavy chain 1	Homo sapiens	28-31
34547407-0	2021	Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic beta-cells.	Iron	115-119	heme oxygenase 1	Homo sapiens	0-16
34547407-0	2021	Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic beta-cells.	Iron	115-119	heme oxygenase 1	Homo sapiens	18-24
34547407-12	2021	Our findings suggest that HMOX1, ID1 and ID3 define the response mechanism against iron-overload-induced stress in beta-cells.	Iron	83-87	heme oxygenase 1	Homo sapiens	26-31
34856399-0	2022	Hepcidin-to-Ferritin Ratio: A Potential Novel Index to Predict Iron Overload-Liver Fibrosis in ss-Thalassemia Major.	Iron	63-67	hepcidin antimicrobial peptide	Homo sapiens	0-8
34856399-1	2022	OBJECTIVES: We aimed to determine a threshold cutoff for hepcidin, ferritin, and the hepcidin-to-ferritin ratio in the diagnosis of liver fibrosis in chronic hepatitis C virus (HCV)-free ss-thalassemia major patients with iron overload.	Iron	222-226	hepcidin antimicrobial peptide	Homo sapiens	57-65
34856399-1	2022	OBJECTIVES: We aimed to determine a threshold cutoff for hepcidin, ferritin, and the hepcidin-to-ferritin ratio in the diagnosis of liver fibrosis in chronic hepatitis C virus (HCV)-free ss-thalassemia major patients with iron overload.	Iron	222-226	hepcidin antimicrobial peptide	Homo sapiens	85-93
34811513-8	2021	Furthermore, we showed that iron played a critical role in mediating Clk1 deficiency-induced alteration in DAT expression, presumably via upstream HIF-1alpha.	Iron	28-32	hypoxia inducible factor 1, alpha subunit	Mus musculus	147-157
34811513-9	2021	Taken together, these data demonstrated that HIF-1alpha-mediated changes in iron homostasis are involved in the Clk1 deficiency-altered METH reward behaviors.	Iron	76-80	hypoxia inducible factor 1, alpha subunit	Mus musculus	45-55
34834095-0	2021	Novel Cellulose Derivatives Containing Metal (Cu, Fe, Ni) Oxide Nanoparticles as Eco-Friendly Corrosion Inhibitors for C-Steel in Acidic Chloride Solutions.	Iron	50-52	ciliogenesis associated kinase 1	Homo sapiens	81-84
34774933-6	2022	XPS analysis confirmed that both Fe(II)-S and bulk S(-II) on FeS surface could be impacted by solution pH and inorganic ions and were responsible for the regulation of HBCD reduction.	Iron	61-64	transcription elongation factor A1	Homo sapiens	51-56
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	43-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	43-47	ferritin heavy chain 1	Homo sapiens	85-89
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	129-133	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
34726357-1	2022	INTRODUCTION: Several studies on obese youths and adults have reported increased hepcidin levels, which seems to be related to metabolic and iron metabolism alterations.	Iron	141-145	hepcidin antimicrobial peptide	Homo sapiens	81-89
34726357-8	2022	In the obese group, a negative correlation between hepcidin and both blood iron levels (p=0.01) and LagPHASE (p=0.02) was found.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	51-59
34726357-10	2022	CONCLUSIONS: We suggest that an increase in hepcidin levels may represent an early step in iron metabolism derangements and metabolic alterations, including NAFLD, in prepubertal obese children.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	44-52
34716241-6	2021	The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis.	Iron	55-59	glutathione peroxidase 4	Mus musculus	147-151
34732557-3	2021	This syndrome is related to an inherited neurodegenerative disorder"s heterogeneous group characterized by the accumulation of iron in the brain, caused by a mutation in the DCAF17 gene.	Iron	127-131	DDB1 and CUL4 associated factor 17	Homo sapiens	174-180
34786173-0	2021	Direct modulation of hepatocyte hepcidin signaling by iron.	Iron	54-58	hepcidin antimicrobial peptide	Homo sapiens	32-40
34786173-1	2021	BACKGROUND: Liver-secreted hepcidin is the systemic master switch of iron homeostasis and decreased levels of hepcidin are considered to cause iron overload not only in hereditary hemochromatosis but also in hemolytic anemia and chronic liver diseases.	Iron	69-73	hepcidin antimicrobial peptide	Homo sapiens	27-35
34786173-1	2021	BACKGROUND: Liver-secreted hepcidin is the systemic master switch of iron homeostasis and decreased levels of hepcidin are considered to cause iron overload not only in hereditary hemochromatosis but also in hemolytic anemia and chronic liver diseases.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	27-35
34786173-1	2021	BACKGROUND: Liver-secreted hepcidin is the systemic master switch of iron homeostasis and decreased levels of hepcidin are considered to cause iron overload not only in hereditary hemochromatosis but also in hemolytic anemia and chronic liver diseases.	Iron	143-147	hepcidin antimicrobial peptide	Homo sapiens	110-118
34786173-2	2021	The regulation of hepcidin is complex and its response to iron is still not completely understood.	Iron	58-62	hepcidin antimicrobial peptide	Homo sapiens	18-26
34786173-3	2021	AIM: To study the direct effect of iron on various established hepcidin signaling pathways in hepatoma cells or primary hepatocytes.	Iron	35-39	hepcidin antimicrobial peptide	Homo sapiens	63-71
34829772-2	2021	Soluble transferrins, such as bovine lactoferrin and hen egg white ovotransferrin, are glycoproteins with a very similar structure with lobes that complex with iron.	Iron	160-164	lactotransferrin	Bos taurus	37-48
34765600-3	2021	Yes-associated protein (YAP) controls intracellular iron levels by affecting the transcription of ferritin heavy chain (FTH) and transferrin receptor (TFRC).	Iron	52-56	ferritin heavy chain 1	Homo sapiens	98-118
34765600-3	2021	Yes-associated protein (YAP) controls intracellular iron levels by affecting the transcription of ferritin heavy chain (FTH) and transferrin receptor (TFRC).	Iron	52-56	ferritin heavy chain 1	Homo sapiens	120-123
34831070-8	2021	Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis.	Iron	12-16	microRNA 221	Homo sapiens	147-154
34831070-8	2021	Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis.	Iron	12-16	microRNA 222	Homo sapiens	159-166
34835988-4	2021	AI is mostly mild to moderate, normochromic and normocytic, and characterized by low circulating iron, but normal and increased levels of the storage protein ferritin and the iron hormone hepcidin.	Iron	175-179	hepcidin antimicrobial peptide	Homo sapiens	188-196
34265052-0	2021	CD63 is Regulated by Iron via the IRE-IRP System and is Important for Ferritin Secretion by Extracellular Vesicles.	Iron	21-25	CD63 molecule	Homo sapiens	0-4
34265052-8	2021	We discovered a canonical IRE in the 5"-untranslated region (UTR) of CD63 mRNA responsible for regulating its expression in response to increased iron.	Iron	146-150	CD63 molecule	Homo sapiens	69-73
34265052-9	2021	Cellular iron-loading caused a marked increase in CD63 expression and the secretion from cells of CD63 positive (i.e., CD63(+)) EVs, which were shown to contain ferritin-H (FtH) and -L (FtL).	Iron	9-13	CD63 molecule	Homo sapiens	50-54
34265052-9	2021	Cellular iron-loading caused a marked increase in CD63 expression and the secretion from cells of CD63 positive (i.e., CD63(+)) EVs, which were shown to contain ferritin-H (FtH) and -L (FtL).	Iron	9-13	CD63 molecule	Homo sapiens	98-102
34405936-3	2021	In the present study, a simple gas-solid treatment with ferrous oxalate has been proposed to uniformly coat a thin spinel phase layer with oxygen vacancy and simultaneously realize Fe-ion substitution in the surface.	Iron	181-183	gastrin	Homo sapiens	31-34
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	27-31	ferritin heavy chain 1	Homo sapiens	146-149
34722507-6	2021	Furthermore, we found that iron accumulation and iron regulatory proteins, including transferrin (Tf), transferrin receptor (CD71), and Ferritin (FTH), increased after radiation treatment, and the silencing of transferrin decreased radiation-induced cell death.	Iron	49-53	ferritin heavy chain 1	Homo sapiens	146-149
34679725-1	2021	Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
34679725-1	2021	Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status.	Iron	182-186	hepcidin antimicrobial peptide	Homo sapiens	0-8
34252441-4	2021	Both abnormal iron metabolism (e.g., iron overload) and lipid peroxidation, which is induced by deletion of glutathione (GSH) or glutathione peroxidase 4 (GPX4), and the accumulation of polyunsaturated fatty acid-containing phospholipids (PUFA-PLs) trigger ferroptosis.	Iron	37-41	glutathione peroxidase 4	Homo sapiens	129-153
34252441-4	2021	Both abnormal iron metabolism (e.g., iron overload) and lipid peroxidation, which is induced by deletion of glutathione (GSH) or glutathione peroxidase 4 (GPX4), and the accumulation of polyunsaturated fatty acid-containing phospholipids (PUFA-PLs) trigger ferroptosis.	Iron	37-41	glutathione peroxidase 4	Homo sapiens	155-159
34601591-2	2022	The recent advances in the knowledge of pathophysiology and molecular basis of iron metabolism have highlighted that HC is caused by mutations in at least five genes, resulting in insufficient hepcidin production or, rarely, resistance to hepcidin action.	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	193-201
34729312-3	2021	However, the strategy by simultaneous iron delivery and GPX4 inhibition has rarely been reported.	Iron	38-42	glutathione peroxidase 4	Homo sapiens	56-60
34729312-4	2021	Herein, novel tumor microenvironments (TME)-activated metal-organic frameworks involving Fe & Cu ions bridged by disulfide bonds with PEGylation (FCSP MOFs) were developed, which would be degraded specifically under the redox TME, simultaneously achieving GSH-depletion induced GPX4 inactivation and releasing Fe ions to produce ROS via Fenton reaction, therefore causing ferroptosis.	Iron	89-91	glutathione peroxidase 4	Homo sapiens	278-282
34542276-2	2021	Herein, we report the design of novel Fe doped CoP hierarchical double-shelled nanocages (Fe-CoP HDSNC) via a MOF-templated approach for highly efficient visible-light-driven CO2 reduction.	Iron	38-40	caspase recruitment domain family member 16	Homo sapiens	47-50
34542276-2	2021	Herein, we report the design of novel Fe doped CoP hierarchical double-shelled nanocages (Fe-CoP HDSNC) via a MOF-templated approach for highly efficient visible-light-driven CO2 reduction.	Iron	38-40	caspase recruitment domain family member 16	Homo sapiens	93-96
34632151-0	2021	Influence of iron binding in the structural stability and cellular internalization of bovine lactoferrin.	Iron	13-17	lactotransferrin	Bos taurus	93-104
34632151-1	2021	Lactoferrin (Lf) is an iron-binding glycoprotein and a component of many external secretions with a wide diversity of functions.	Iron	23-27	lactotransferrin	Bos taurus	0-11
34583348-7	2021	A cross-sectional study was conducted to determine the association between plasma levels of free heme, HO-1, Hp, Hx, and malaria status in pregnant women who received routine iron supplementation and their birth outcomes.	Iron	175-179	heme oxygenase 1	Homo sapiens	103-107
34646852-0	2021	Leptin Receptor-Deficient db/db Mice Show Significant Heterogeneity in Response to High Non-heme Iron Diet.	Iron	97-101	leptin receptor	Mus musculus	0-15
34572080-3	2021	In this study, we investigated different aspects involved in ESCs" response to iron accumulation following stable knockdown of the ferritin heavy chain (FTH1) gene, which encodes for a major iron storage protein with ferroxidase activity.	Iron	79-83	ferritin heavy chain 1	Homo sapiens	131-151
34572080-3	2021	In this study, we investigated different aspects involved in ESCs" response to iron accumulation following stable knockdown of the ferritin heavy chain (FTH1) gene, which encodes for a major iron storage protein with ferroxidase activity.	Iron	79-83	ferritin heavy chain 1	Homo sapiens	153-157
34572080-3	2021	In this study, we investigated different aspects involved in ESCs" response to iron accumulation following stable knockdown of the ferritin heavy chain (FTH1) gene, which encodes for a major iron storage protein with ferroxidase activity.	Iron	191-195	ferritin heavy chain 1	Homo sapiens	131-151
34572080-3	2021	In this study, we investigated different aspects involved in ESCs" response to iron accumulation following stable knockdown of the ferritin heavy chain (FTH1) gene, which encodes for a major iron storage protein with ferroxidase activity.	Iron	191-195	ferritin heavy chain 1	Homo sapiens	153-157
34519748-0	2021	Facile synthesis of Fe-doped CoP nanosheet arrays wrapped by graphene for overall water splitting.	Iron	20-22	caspase recruitment domain family member 16	Homo sapiens	29-32
34519748-2	2021	This study proposes an effective strategy for the construction of Fe doped CoP nanosheet arrays wrapped by graphene (F0.25CP-G) on nickel foam as an efficient electrocatalyst for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER).	Iron	66-68	caspase recruitment domain family member 16	Homo sapiens	75-78
34572377-7	2021	Hepcidin was associated with iron status parameters.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
34572377-9	2021	Hepcidin may be a surrogate biomarker of iron status and metabolism in patients with chronic respiratory diseases.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	0-8
34496740-8	2021	Mechanistically, increased heme catabolism and downregulation of glutathione peroxidase 4 (GPX4) levels were detected in herniated nucleus pulposus, reflecting iron-dependent cell death or ferroptosis.	Iron	160-164	glutathione peroxidase 4	Homo sapiens	65-89
34496740-8	2021	Mechanistically, increased heme catabolism and downregulation of glutathione peroxidase 4 (GPX4) levels were detected in herniated nucleus pulposus, reflecting iron-dependent cell death or ferroptosis.	Iron	160-164	glutathione peroxidase 4	Homo sapiens	91-95
34132349-2	2021	Neonates of obese women may be at risk for poor iron status at birth as a result of maternal inflammation-driven overexpression of hepcidin.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	131-139
34236433-0	2021	Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples.	Iron	114-118	erythroferrone	Homo sapiens	15-29
34236433-2	2021	Erythroferrone (ERFE) is a recently identified iron regulatory hormone, and normative data on ERFE concentrations and relations between iron status and other iron regulatory hormones at birth are needed.	Iron	47-51	erythroferrone	Homo sapiens	0-14
34236433-2	2021	Erythroferrone (ERFE) is a recently identified iron regulatory hormone, and normative data on ERFE concentrations and relations between iron status and other iron regulatory hormones at birth are needed.	Iron	47-51	erythroferrone	Homo sapiens	16-20
34091657-9	2021	Drinking frequency was also related to decreased placental ferroportin-1:transferrin receptor-1 (beta = -0.57 for logged values; 95% CI: -1.03 to -0.10), indicating iron-restricted placental iron transport.	Iron	165-169	solute carrier family 40 member 1	Homo sapiens	59-72
34091657-9	2021	Drinking frequency was also related to decreased placental ferroportin-1:transferrin receptor-1 (beta = -0.57 for logged values; 95% CI: -1.03 to -0.10), indicating iron-restricted placental iron transport.	Iron	191-195	solute carrier family 40 member 1	Homo sapiens	59-72
34287090-7	2021	In-vitro and in-vivo iron treatment resulted in the downregulation of PPARalpha, Sirt3, active beta-catenin and its downstream target gene c-Myc in the mouse liver.	Iron	21-25	sirtuin 3	Mus musculus	81-86
34287090-8	2021	Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression.	Iron	144-148	sirtuin 3	Mus musculus	30-35
34287090-8	2021	Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression.	Iron	210-214	sirtuin 3	Mus musculus	30-35
34287090-8	2021	Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression.	Iron	210-214	transforming growth factor alpha	Mus musculus	252-259
34287090-10	2021	In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis.	Iron	26-30	sirtuin 3	Mus musculus	165-170
34287090-10	2021	In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis.	Iron	128-132	sirtuin 3	Mus musculus	165-170
34287090-11	2021	Thus, our results establish a novel link between hepatic iron and PPARalpha, Sirt3 and beta-catenin signaling.	Iron	57-61	sirtuin 3	Mus musculus	77-82
34215630-0	2021	Colorectal Cancer Cells Ectopically Express Hepcidin to Sequester Iron.	Iron	66-70	hepcidin antimicrobial peptide	Homo sapiens	44-52
34215630-1	2021	Colorectal cancer cells express hepcidin to accumulate iron, promoting nucleotide metabolism.	Iron	55-59	hepcidin antimicrobial peptide	Homo sapiens	32-40
34298093-7	2021	Heme-iron induced lipid peroxidation and DNA oxidation by interacting with Nox4-independent mechanisms, promoting p53/p21 activity and cellular senescence.	Iron	5-9	H3 histone pseudogene 16	Homo sapiens	118-121
34091174-6	2021	While quercetin contains several phenolic hydroxyl groups, it is found that only the C-3"-OH group can effectively donate an electron for the reduction of heme because it not only can bind closely and tightly inside the peroxidase sites of COX-1/2, but it can also facilely donate an electron to heme Fe ion.	Iron	301-303	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	240-247
34294362-5	2021	Changes in circulating hepcidin levels, a negative regulator of intestinal iron uptake, after 2 weeks of CERA treatment were significantly lower in the weekly therapy compared with the biweekly therapy (-4.2 +- 6.3 vs 11.1 +- 7.3 ng/mL, P = 0.015).	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	23-31
34420657-2	2021	Key mediators of systemic iron homeostasis are the iron regulatory hormone hepcidin and its receptor, the iron export protein ferroportin.	Iron	26-30	hepcidin antimicrobial peptide	Homo sapiens	75-83
34420657-2	2021	Key mediators of systemic iron homeostasis are the iron regulatory hormone hepcidin and its receptor, the iron export protein ferroportin.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	75-83
34420657-2	2021	Key mediators of systemic iron homeostasis are the iron regulatory hormone hepcidin and its receptor, the iron export protein ferroportin.	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	75-83
34420657-4	2021	demonstrates the functional role of the hepcidin-ferroportin axis in the kidney, and how this contributes to kidney iron levels and the systemic iron economy.	Iron	116-120	hepcidin antimicrobial peptide	Homo sapiens	40-48
34420657-4	2021	demonstrates the functional role of the hepcidin-ferroportin axis in the kidney, and how this contributes to kidney iron levels and the systemic iron economy.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	40-48
34474835-5	2021	Magnetoferritin is synthesized by loading iron in apoferritin in anaerobic condition at 65  C. The loading method results in one order of magnitude enhancement of r1 and r2 relaxivities compared to standard ferritin synthesized by aerobic loading of iron at room temperature.	Iron	42-46	ferritin heavy chain 1	Homo sapiens	50-61
34471098-5	2021	Across patients, decreased tissue iron concentration (as indexed by higher nT2*w) in striatal regions correlated with indices of decreased cognitive-affective function on the Affective Go/NoGo task.	Iron	34-38	reticulon 4	Homo sapiens	188-192
34571900-4	2021	We recorded the expression patterns of key proteins of iron homeostasis involved in iron import, export and storage and examined their relation to the iron regulatory hormone hepcidin in hepatocytes, enterocytes and macrophages in the presence and absence of HCV.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	175-183
34707440-1	2021	Gram-negative bacterium Neisseria meningitidis, responsible for human infectious disease meningitis, acquires the iron (Fe3+) ion needed for its survival from human transferrin protein (hTf).	Iron	114-118	coagulation factor III, tissue factor	Homo sapiens	186-189
34218987-8	2021	Similarly, FE induced a significant rise in TNFalpha, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05).	Iron	11-13	coagulation factor III, tissue factor	Homo sapiens	54-56
34218987-8	2021	Similarly, FE induced a significant rise in TNFalpha, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05).	Iron	11-13	serpin family E member 1	Homo sapiens	74-79
34420232-4	2021	This research work developed an iron nanomaterial-based linker to attach osteopontin-specific aptamer on PS substrate.	Iron	32-36	secreted phosphoprotein 1	Homo sapiens	73-84
34442028-2	2021	Hepcidin is the key element involved in iron metabolism; however, studies on new indices of iron status are still ongoing.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
34415720-0	2021	MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy.	Iron	100-102	C-C motif chemokine ligand 2	Homo sapiens	0-5
34415720-4	2021	In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility.	Iron	86-90	C-C motif chemokine ligand 2	Homo sapiens	190-195
34415720-4	2021	In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility.	Iron	130-132	C-C motif chemokine ligand 2	Homo sapiens	39-73
34415720-4	2021	In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility.	Iron	130-132	C-C motif chemokine ligand 2	Homo sapiens	190-195
34415720-4	2021	In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility.	Iron	208-210	C-C motif chemokine ligand 2	Homo sapiens	39-73
34415720-4	2021	In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility.	Iron	208-210	C-C motif chemokine ligand 2	Homo sapiens	75-80
34415720-4	2021	In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility.	Iron	208-210	C-C motif chemokine ligand 2	Homo sapiens	190-195
34415720-5	2021	The results of TEM, UV-vis, and FTIR all confirmed that we"d synthesized MCP-1/GNR@MIL-100(Fe) successfully, and the MCP-1/GNR@MIL-100(Fe) also showed good biocompatibility.	Iron	91-93	C-C motif chemokine ligand 2	Homo sapiens	73-78
34415720-5	2021	The results of TEM, UV-vis, and FTIR all confirmed that we"d synthesized MCP-1/GNR@MIL-100(Fe) successfully, and the MCP-1/GNR@MIL-100(Fe) also showed good biocompatibility.	Iron	135-137	C-C motif chemokine ligand 2	Homo sapiens	117-122
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	184-188	SMAD family member 4	Mus musculus	31-36
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	184-188	SMAD family member 4	Mus musculus	131-136
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	346-350	SMAD family member 4	Mus musculus	31-36
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	346-350	SMAD family member 4	Mus musculus	131-136
34399682-13	2021	CONCLUSION: miR-3074-5p functions as an apoptosis promoter in iron-overloaded MC3T3-E1 cells by directly targeting Smad4.	Iron	62-66	SMAD family member 4	Mus musculus	115-120
34283245-2	2021	Human aspartyl (asparaginyl) beta-hydroxylase (HAAH), a unique iron and 2-oxoglutarate dependent oxygenase, has shown increased importance as a suspected oncogenic protein.	Iron	63-67	aspartate beta-hydroxylase	Homo sapiens	6-45
34283245-2	2021	Human aspartyl (asparaginyl) beta-hydroxylase (HAAH), a unique iron and 2-oxoglutarate dependent oxygenase, has shown increased importance as a suspected oncogenic protein.	Iron	63-67	aspartate beta-hydroxylase	Homo sapiens	47-51
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	80-82	caspase recruitment domain family member 16	Homo sapiens	153-156
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	144-146	caspase recruitment domain family member 16	Homo sapiens	44-47
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	144-146	caspase recruitment domain family member 16	Homo sapiens	83-86
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	144-146	caspase recruitment domain family member 16	Homo sapiens	153-156
34368018-12	2021	This suggests that upon pharmacological inhibition of the central SMAD-BMP pathways during infection, other signaling cascades are compensatorily induced to ensure sufficient hepcidin formation and iron restriction to circulating microbes.	Iron	198-202	bone morphogenetic protein 6	Mus musculus	71-74
34444676-9	2021	This study shed a new light in effective iron recovery pathways after SG involving suppression of inflammation, improvement of iron absorption, iron supply and efficiency of erythropoiesis, and finally beneficial control of iron homeostasis by hepcidin.	Iron	41-45	hepcidin antimicrobial peptide	Homo sapiens	244-252
34444676-9	2021	This study shed a new light in effective iron recovery pathways after SG involving suppression of inflammation, improvement of iron absorption, iron supply and efficiency of erythropoiesis, and finally beneficial control of iron homeostasis by hepcidin.	Iron	224-228	hepcidin antimicrobial peptide	Homo sapiens	244-252
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Iron	186-190	hemopexin	Mus musculus	28-37
34281283-1	2021	beta-thalassaemia is a rare genetic condition caused by mutations in the beta-globin gene that result in severe iron-loading anaemia, maintained by a detrimental state of ineffective erythropoiesis (IE).	Iron	112-116	hemoglobin subunit beta	Homo sapiens	73-84
34077792-5	2021	Two types of transferrin receptors (TfRs), TfR1 and TfR2, are known to play a role in iron uptake in erythroid cells.	Iron	86-90	transferrin receptor 2	Homo sapiens	52-56
34157011-12	2021	More detailed studies are needed to clarify the role of ERFE in iron metabolism in the patients with thalassemias.	Iron	64-68	erythroferrone	Homo sapiens	56-60
34277457-1	2021	Background: Hepcidin is a polypeptide hormone mainly produced by hepatocytes to modulate systemic iron balance.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	12-20
34345202-11	2021	As a downstream gene (effector) of Nrf2, heme oxygenase-1 (HO-1) expression increased significantly with the treatment of tagitinin C. Upregulated HO-1 led to the increase in the labile iron pool, which promoted lipid peroxidation, meanwhile tagitinin C showed synergistic anti-tumor effect together with erastin.	Iron	186-190	heme oxygenase 1	Homo sapiens	147-151
34161397-0	2021	Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes.	Iron	0-4	bone morphogenetic protein 1	Homo sapiens	23-26
34161397-0	2021	Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	60-68
34161397-1	2021	Hepcidin is a peptide hormone that targets the iron exporter ferroportin, thereby limiting iron entry into the bloodstream.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
34161397-1	2021	Hepcidin is a peptide hormone that targets the iron exporter ferroportin, thereby limiting iron entry into the bloodstream.	Iron	91-95	hepcidin antimicrobial peptide	Homo sapiens	0-8
34161397-3	2021	Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liver sinusoidal endothelial cells, which in turn binds to BMP receptors on hepatocytes and induces the SMAD signaling cascade for transcriptional activation of the hepcidin-encoding HAMP mRNA.	Iron	0-4	bone morphogenetic protein 1	Homo sapiens	130-133
34161397-3	2021	Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liver sinusoidal endothelial cells, which in turn binds to BMP receptors on hepatocytes and induces the SMAD signaling cascade for transcriptional activation of the hepcidin-encoding HAMP mRNA.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	236-244
34161397-3	2021	Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liver sinusoidal endothelial cells, which in turn binds to BMP receptors on hepatocytes and induces the SMAD signaling cascade for transcriptional activation of the hepcidin-encoding HAMP mRNA.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	254-258
34161397-7	2021	Subsequent iron supplementation not only failed to reverse these effects, but drastically reduced basal HAMP mRNA and inhibited HAMP mRNA induction by BMP6 and/or IL-6.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	104-108
34161397-7	2021	Subsequent iron supplementation not only failed to reverse these effects, but drastically reduced basal HAMP mRNA and inhibited HAMP mRNA induction by BMP6 and/or IL-6.	Iron	11-15	hepcidin antimicrobial peptide	Homo sapiens	128-132
34161397-8	2021	Thus, treatment of cells with excess iron inhibited basal and BMP6-mediated SMAD5 phosphorylation and induction of HAMP, ID1 and SMAD7 mRNAs in a dose-dependent manner.	Iron	37-41	hepcidin antimicrobial peptide	Homo sapiens	115-119
34161397-9	2021	Iron also inhibited IL-6-mediated STAT3 phosphorylation and induction of HAMP and SOCS3 mRNAs.	Iron	0-4	hepcidin antimicrobial peptide	Homo sapiens	73-77
34188474-11	2021	Iron concentration was positively correlated with IL-1beta concentration in the PD-EDS group.	Iron	0-4	interleukin 1 alpha	Homo sapiens	50-58
34143808-3	2021	The pathogenesis of this "anemia of inflammation" (AI) involves cytokine-mediated transactivation of hepatic Hamp (encoding the iron-regulatory hormone, hepcidin).	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	109-113
34143808-3	2021	The pathogenesis of this "anemia of inflammation" (AI) involves cytokine-mediated transactivation of hepatic Hamp (encoding the iron-regulatory hormone, hepcidin).	Iron	128-132	hepcidin antimicrobial peptide	Homo sapiens	153-161
34143808-4	2021	In AI, high hepcidin represses iron absorption (and iron release from stores), thus lowering serum iron, and restricting iron for erythropoiesis (causing anemia).	Iron	31-35	hepcidin antimicrobial peptide	Homo sapiens	12-20
34143808-4	2021	In AI, high hepcidin represses iron absorption (and iron release from stores), thus lowering serum iron, and restricting iron for erythropoiesis (causing anemia).	Iron	52-56	hepcidin antimicrobial peptide	Homo sapiens	12-20
34143808-4	2021	In AI, high hepcidin represses iron absorption (and iron release from stores), thus lowering serum iron, and restricting iron for erythropoiesis (causing anemia).	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	12-20
34143808-4	2021	In AI, high hepcidin represses iron absorption (and iron release from stores), thus lowering serum iron, and restricting iron for erythropoiesis (causing anemia).	Iron	121-125	hepcidin antimicrobial peptide	Homo sapiens	12-20
34143808-6	2021	We hypothesized that localized gut inflammation will increase overall iron demand (to support the immune response and tissue repair), and that hepatic Hamp expression will decrease in response, thus derepressing (i.e., enhancing) iron absorption.	Iron	230-234	hepcidin antimicrobial peptide	Homo sapiens	151-155
34204327-0	2021	Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	0-8
34204327-2	2021	In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1).	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	192-200
34204327-2	2021	In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1).	Iron	33-37	solute carrier family 40 member 1	Homo sapiens	259-266
34204327-2	2021	In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1).	Iron	106-110	hepcidin antimicrobial peptide	Homo sapiens	192-200
34204327-2	2021	In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1).	Iron	106-110	solute carrier family 40 member 1	Homo sapiens	259-266
34204327-2	2021	In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1).	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	192-200
34204327-2	2021	In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1).	Iron	160-164	solute carrier family 40 member 1	Homo sapiens	259-266
34204327-2	2021	In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1).	Iron	232-236	solute carrier family 40 member 1	Homo sapiens	259-266
34204327-4	2021	Hepcidin blocks iron export through ferroportin, causing hypoferremia.	Iron	16-20	hepcidin antimicrobial peptide	Homo sapiens	0-8
34204327-5	2021	During iron deficiency or after hemorrhage, hepcidin decreases to allow iron delivery to plasma through ferroportin, thus promoting compensatory erythropoiesis.	Iron	72-76	hepcidin antimicrobial peptide	Homo sapiens	44-52
34204327-6	2021	As a host defense mediator, hepcidin increases in response to infection and inflammation, blocking iron delivery through ferroportin to blood plasma, thus limiting iron availability to invading microbes.	Iron	99-103	hepcidin antimicrobial peptide	Homo sapiens	28-36
34204327-6	2021	As a host defense mediator, hepcidin increases in response to infection and inflammation, blocking iron delivery through ferroportin to blood plasma, thus limiting iron availability to invading microbes.	Iron	164-168	hepcidin antimicrobial peptide	Homo sapiens	28-36
34204327-7	2021	Genetic diseases that decrease hepcidin synthesis or disrupt hepcidin binding to ferroportin cause the iron overload disorder hereditary hemochromatosis.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	31-39
34204327-7	2021	Genetic diseases that decrease hepcidin synthesis or disrupt hepcidin binding to ferroportin cause the iron overload disorder hereditary hemochromatosis.	Iron	103-107	hepcidin antimicrobial peptide	Homo sapiens	61-69
34204327-8	2021	The opposite phenotype, iron restriction or iron deficiency, can result from genetic or inflammatory overproduction of hepcidin.	Iron	24-28	hepcidin antimicrobial peptide	Homo sapiens	119-127
34188614-8	2021	The data were subsequently used to determine the spatial distribution of either iron or cobalt atoms incorporated into the ferritin/apoferritin protein cages.	Iron	80-84	ferritin heavy chain 1	Homo sapiens	132-143
34218583-8	2021	Multilinear regression analysis showed C0, SF, sTFR and HGB were independent factors for Hepcidin in iron deficient patients, with an equation of Hepcidin=-31.842-0.642*C0+2.239*SF+1.778*sTFR+0.365*HGB-0.274*RET-HB.	Iron	101-105	hepcidin antimicrobial peptide	Homo sapiens	89-97
34218583-13	2021	Hepcidin was a better parameter to distinguish iron absorption level among different iron deficient patients than C2-C0 of oral iron absorption test.	Iron	47-51	hepcidin antimicrobial peptide	Homo sapiens	0-8
34218583-13	2021	Hepcidin was a better parameter to distinguish iron absorption level among different iron deficient patients than C2-C0 of oral iron absorption test.	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	0-8
34094837-6	2021	Meanwhile, the activity of DNA repair enzyme was also inhibited with the reduction of iron ion, resulting in the aggravated DNA damage in tumor cells.	Iron	86-90	DNA ligase 4	Homo sapiens	27-44
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	109-111	H2B clustered histone 21	Homo sapiens	117-120
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	109-111	secreted phosphoprotein 1	Homo sapiens	218-222
34366375-3	2021	Copper or iron chelators, that bind excess or labile metal ions, can prevent aggregation of alpha-synuclein in the brain and alleviate motor-symptoms in preclinical models of PD.	Iron	10-14	synuclein alpha	Homo sapiens	92-107
35597263-0	2022	Development of antibodies to the iron-binding proteins transferrin and ferritin in dogs and mice infected with Leishmania parasites.	Iron	33-37	inhibitor of carbonic anhydrase	Canis lupus familiaris	55-66
35623403-1	2022	Hepcidin, a key regulator of iron homeostasis, has been implicated in the pathogenesis of various iron-related diseases.	Iron	29-33	hepcidin antimicrobial peptide	Homo sapiens	0-8
35623403-1	2022	Hepcidin, a key regulator of iron homeostasis, has been implicated in the pathogenesis of various iron-related diseases.	Iron	98-102	hepcidin antimicrobial peptide	Homo sapiens	0-8
35500487-0	2022	Effects of saltwater intrusion and sea level rise on aging and corrosion rates of iron pipes in water distribution and wastewater collection systems in coastal areas.	Iron	82-86	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
35500487-2	2022	This paper provides a quantitative assessment of projected shifts in failure rates of iron pipes due to saltwater intrusion and sea level rise in coastal areas.	Iron	86-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	128-131
35487149-4	2022	ArsI is a non-heme ferrous iron (Fe(II))-dependent dioxygenase that catalyzes oxygen-dependent cleavage of the carbon-arsenic (C-As) bond in trivalent organoarsenicals, degrading them to inorganic As(III).	Iron	27-31	arylsulfatase family member I	Homo sapiens	0-4
35477124-1	2022	Lactoferrin (Lf) is an iron-binding glycoprotein with potentially beneficial biological functions.	Iron	23-27	lactotransferrin	Mus musculus	0-11
35147903-2	2022	As a ferroxidase, ceruloplasmin (Cp) plays a key role in iron homeostasis and its abnormal activity leads to iron accumulation.	Iron	57-61	ceruloplasmin	Mus musculus	18-31
35147903-2	2022	As a ferroxidase, ceruloplasmin (Cp) plays a key role in iron homeostasis and its abnormal activity leads to iron accumulation.	Iron	109-113	ceruloplasmin	Mus musculus	5-16
35147903-2	2022	As a ferroxidase, ceruloplasmin (Cp) plays a key role in iron homeostasis and its abnormal activity leads to iron accumulation.	Iron	109-113	ceruloplasmin	Mus musculus	18-31
35258176-2	2022	Notch3 signaling is reported to be involved in the tumorigenesis of non-small-cell lung cancer (NSCLC) and regulates iron metabolism, lipid synthesis, and oxidative stress in some tissues.	Iron	117-121	notch receptor 3	Homo sapiens	0-6
35487023-2	2022	In a recent study, we reported alterations in the serum levels of hepcidin and other iron-related proteins in Alzheimer"s disease (AD) patients (Sternberg et al., 2017).	Iron	85-89	hepcidin antimicrobial peptide	Homo sapiens	66-74
35487023-7	2022	Furthermore, Spermidine serum levels correlated with serum levels of the chief iron regulatory protein, hepcidin in AD participants with a more advanced disease stage, indicated by MMSE (strata of 8-19, P = 0.02), and CDR-SOB (strata of 6-12, P = 0.03).	Iron	79-83	hepcidin antimicrobial peptide	Homo sapiens	104-112
35379462-3	2022	Lactoferrin is divided into 2 types, namely apo-LF and holo-LF, depending on the degree of iron saturation, which may affect its bioactivities.	Iron	91-95	lactotransferrin	Mus musculus	0-11
35379462-7	2022	Moreover, the specific mechanism of the LF with optimal iron saturation was further investigated through Western blot assay.	Iron	56-60	lactotransferrin	Mus musculus	40-42
35061889-11	2022	Additional experimentation suggested that intestinal DMT1 was required for enhancement of iron transport by the 4AAs.	Iron	90-94	solute carrier family 11 member 2	Homo sapiens	53-57
35061889-12	2022	Select AA thus enhance iron absorption by inducing DMT1 trafficking onto the apical membrane of duodenal enterocytes.	Iron	23-27	solute carrier family 11 member 2	Homo sapiens	51-55
35598199-4	2022	METHODS AND RESULTS: Proteomic analyses found that ATO can affect the signaling pathway associated with ferroptosis, including the upregulation of iron absorption (FTL, FTH1, HO-1), ferritinophagy (LC3, P62, ATG7, NCOA4) and modifier of glutathione synthesis (GCLM); downregulation of glutamine synthetase (GS) and GPX4, which was the critical inhibitor of ferroptosis.	Iron	147-151	ferritin heavy chain 1	Homo sapiens	169-173
35598199-4	2022	METHODS AND RESULTS: Proteomic analyses found that ATO can affect the signaling pathway associated with ferroptosis, including the upregulation of iron absorption (FTL, FTH1, HO-1), ferritinophagy (LC3, P62, ATG7, NCOA4) and modifier of glutathione synthesis (GCLM); downregulation of glutamine synthetase (GS) and GPX4, which was the critical inhibitor of ferroptosis.	Iron	147-151	heme oxygenase 1	Homo sapiens	175-179
35598199-7	2022	CONCLUSIONS: Our study revealed that ATO may induce ferroptosis in neuroblastoma cell SK-N-BE (2) by facilitating the downregulation of GPX4, ultimately resulting in iron-dependent oxidative death.	Iron	166-170	glutathione peroxidase 4	Homo sapiens	136-140
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	157-161	hepcidin antimicrobial peptide	Homo sapiens	92-100
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	174-178	heme oxygenase 1	Homo sapiens	60-64
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	174-178	hepcidin antimicrobial peptide	Homo sapiens	92-100
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	267-271	heme oxygenase 1	Homo sapiens	60-64
35603834-7	2022	Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism.	Iron	267-271	hepcidin antimicrobial peptide	Homo sapiens	92-100
35609862-5	2022	It has been shown that mitoNEET has a crucial role in energy metabolism, iron homeostasis, and free radical production in cells.	Iron	73-77	CDGSH iron sulfur domain 1	Homo sapiens	23-31
35247909-6	2022	The upregulation of IDO1 in cancer cells acted as an immunosuppressive feedback mechanism to limit the proliferation and function of cytotoxic CD8+ T lymphocytes through iron-dependent kynurenine production and subsequent TSPAN5-mediated kynurenine secretion.	Iron	170-174	indoleamine 2,3-dioxygenase 1	Mus musculus	20-24
35411952-0	2022	DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion.	Iron	87-91	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
35411952-6	2022	DGAT1-dependent lipid droplet biosynthesis occurred several hours before mitochondrial clearance, with lipid droplets bordering mitochondria upon iron chelation.	Iron	146-150	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	Iron	197-201	catenin beta 1	Homo sapiens	111-123
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	Iron	197-201	solute carrier family 7 member 11	Homo sapiens	129-136
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	Iron	197-201	solute carrier family 40 member 1	Homo sapiens	137-141
35628152-2	2022	In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a considerable amount of iron is required daily for hemoglobin synthesis and erythroid cell proliferation.	Iron	133-137	myoglobin	Homo sapiens	52-61
35628152-4	2022	The liver-derived hormone hepcidin, which controls iron homeostasis via its interaction with the iron exporter ferroportin, coordinates erythropoietic activity and iron homeostasis.	Iron	51-55	hepcidin antimicrobial peptide	Homo sapiens	26-34
35628152-4	2022	The liver-derived hormone hepcidin, which controls iron homeostasis via its interaction with the iron exporter ferroportin, coordinates erythropoietic activity and iron homeostasis.	Iron	97-101	hepcidin antimicrobial peptide	Homo sapiens	26-34
35628152-4	2022	The liver-derived hormone hepcidin, which controls iron homeostasis via its interaction with the iron exporter ferroportin, coordinates erythropoietic activity and iron homeostasis.	Iron	164-168	hepcidin antimicrobial peptide	Homo sapiens	26-34
35628152-5	2022	When erythropoiesis is enhanced, iron availability to the erythron is mainly ensured by inhibiting hepcidin expression, thereby increasing ferroportin-mediated iron export from both duodenal absorptive cells and reticuloendothelial cells that process old and/or damaged red blood cells.	Iron	33-37	hepcidin antimicrobial peptide	Homo sapiens	99-107
35628152-5	2022	When erythropoiesis is enhanced, iron availability to the erythron is mainly ensured by inhibiting hepcidin expression, thereby increasing ferroportin-mediated iron export from both duodenal absorptive cells and reticuloendothelial cells that process old and/or damaged red blood cells.	Iron	160-164	hepcidin antimicrobial peptide	Homo sapiens	99-107
35628152-6	2022	Erythroferrone, a factor produced and secreted by erythroid precursors in response to erythropoietin, has been identified and characterized as a suppressor of hepcidin synthesis to allow iron mobilization and facilitate erythropoiesis.	Iron	187-191	hepcidin antimicrobial peptide	Homo sapiens	159-167
35532871-14	2022	We suggest that hepcidin and sTfR should be measured to identify patients with true iron deficiency, who might benefit from treatment with intravenous iron.	Iron	151-155	hepcidin antimicrobial peptide	Homo sapiens	16-24
35465676-4	2022	Significantly, the FE and NH3 yield of TiO2/Ag/Cu7S4@Se-CC reached 51.05 +- 0.16% and 39.16 +- 2.31 mug h-1 cm-2, in which the FE is among the highest non-precious metal-based NRR electrocatalysts in alkaline electrolytes reported.	Iron	19-21	H1.5 linker histone, cluster member	Homo sapiens	104-112
35465676-4	2022	Significantly, the FE and NH3 yield of TiO2/Ag/Cu7S4@Se-CC reached 51.05 +- 0.16% and 39.16 +- 2.31 mug h-1 cm-2, in which the FE is among the highest non-precious metal-based NRR electrocatalysts in alkaline electrolytes reported.	Iron	127-129	H1.5 linker histone, cluster member	Homo sapiens	104-112
35522478-5	2022	Owing to the presence of highly exposed Fe-N-C sites and well-tuned pore structures, isolated Fe atoms on porous carbon nanofiber framework (Fe-SA/NCF) exhibits decent oxygen reduction activity and stability in alkaline conditions via a near four-electron path, demonstrating superior performance as air cathode for zinc-air batteries (ZABs) to commercial Pt/C catalyst.	Iron	40-42	neutrophil cytosolic factor 4	Homo sapiens	147-150
35522478-5	2022	Owing to the presence of highly exposed Fe-N-C sites and well-tuned pore structures, isolated Fe atoms on porous carbon nanofiber framework (Fe-SA/NCF) exhibits decent oxygen reduction activity and stability in alkaline conditions via a near four-electron path, demonstrating superior performance as air cathode for zinc-air batteries (ZABs) to commercial Pt/C catalyst.	Iron	94-96	neutrophil cytosolic factor 4	Homo sapiens	147-150
35599858-10	2022	We determined that iron distribution is modified in abi3, lec2, and fus3 embryo mutants.	Iron	19-23	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	52-56
35599858-11	2022	For abi3-6 and fus3-3 mutant embryos, iron was less accumulated in vacuoles of cells surrounding provasculature compared with wild type embryos.	Iron	38-42	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	4-8
35599858-15	2022	Altogether our results support a role of the B3 transcription factors ABI3, LEC2, and FUS3 in maintaining iron homeostasis in Arabidopsis embryos.	Iron	106-110	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	70-74
35467875-6	2022	We demonstrate the BuRNN approach by performing NN/MM simulations of the hexa-aqua iron complex.	Iron	83-87	hexosaminidase subunit alpha	Homo sapiens	73-77
35513392-0	2022	Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.	Iron	101-105	solute carrier family 25 member 39	Homo sapiens	45-53
35513392-7	2022	GxG analysis highlights a buffering interaction between the iron transporter SLC25A37 (A37) and the poorly characterized SLC25A39 (A39).	Iron	60-64	solute carrier family 25 member 39	Homo sapiens	121-129
35504898-8	2022	Mechanistically, we found that de-O-GlcNAcylation of the ferritin heavy chain at S179 promoted its interaction with NCOA4, the ferritinophagy receptor, thereby accumulating labile iron for ferroptosis.	Iron	180-184	ferritin heavy chain 1	Homo sapiens	57-77
35565873-2	2022	The iron regulatory hormone hepcidin may be involved in IDA and/or ID.	Iron	4-8	hepcidin antimicrobial peptide	Homo sapiens	28-36
35538889-9	2022	Mechanistically, AMPKalpha1 directly phosphorylated prolyl hydroxylase domain-containing (PHD)2 at serines 61 and 136, which suppressed PHD2-dependent hydroxylation of hypoxia-inducible factor (HIF)1alpha and subsequent regulation of hepatic hepcidin-related iron signalling.	Iron	259-263	egl-9 family hypoxia-inducible factor 1	Mus musculus	52-95
35538889-9	2022	Mechanistically, AMPKalpha1 directly phosphorylated prolyl hydroxylase domain-containing (PHD)2 at serines 61 and 136, which suppressed PHD2-dependent hydroxylation of hypoxia-inducible factor (HIF)1alpha and subsequent regulation of hepatic hepcidin-related iron signalling.	Iron	259-263	egl-9 family hypoxia-inducible factor 1	Mus musculus	136-140
35538889-9	2022	Mechanistically, AMPKalpha1 directly phosphorylated prolyl hydroxylase domain-containing (PHD)2 at serines 61 and 136, which suppressed PHD2-dependent hydroxylation of hypoxia-inducible factor (HIF)1alpha and subsequent regulation of hepatic hepcidin-related iron signalling.	Iron	259-263	hypoxia inducible factor 1, alpha subunit	Mus musculus	168-204
35538889-10	2022	Inhibition of PHD2 hydroxylation ameliorated abnormal iron metabolism in hepatic AMPKalpha1-deficient mice.	Iron	54-58	egl-9 family hypoxia-inducible factor 1	Mus musculus	14-18
35477031-12	2022	CONCLUSIONS: MRI relaxometry and serum hepcidin accurately assessed mild iron overload in patients with dysmetabolic iron overload syndrome.	Iron	73-77	hepcidin antimicrobial peptide	Homo sapiens	39-47
35477731-7	2022	A modest but statistically significant rise in E-selectin was noted in the intravenous iron group at 1 month and 3 month follow-up (p = 0.030 and p = 0.002 respectively).	Iron	87-91	selectin E	Homo sapiens	47-57
35472140-9	2022	RESULTS: We confirmed the well-known roles of CB2 and TRPV1 receptors in bone metabolism and suggested that their stimulation can reduce the OC overactivity induced by iron, providing new insights into the pathogenesis of pediatric IBD-related bone resorption.	Iron	168-172	cannabinoid receptor 2	Homo sapiens	46-49
35472140-10	2022	CONCLUSIONS: Stimulation of CB2 and TRPV1 could reduce IBD-related osteoporosis due to their direct effects on OC activity and to modulating the iron metabolism.	Iron	145-149	cannabinoid receptor 2	Homo sapiens	28-31
35558525-0	2022	The Relationship Between Hepcidin-Mediated Iron Dysmetabolism and COVID-19 Severity: A Meta-Analysis.	Iron	43-47	hepcidin antimicrobial peptide	Homo sapiens	25-33
35558525-1	2022	Backgrounds: Hepcidin has been identified as a systemic iron-regulatory hormone.	Iron	56-60	hepcidin antimicrobial peptide	Homo sapiens	13-21
35558525-3	2022	Objectives: To re-evaluate the hepcidin-related iron metabolism parameters and explore the relationship between hepcidin-mediated iron dysmetabolism and COVID-19 severity.	Iron	48-52	hepcidin antimicrobial peptide	Homo sapiens	31-39
35558525-3	2022	Objectives: To re-evaluate the hepcidin-related iron metabolism parameters and explore the relationship between hepcidin-mediated iron dysmetabolism and COVID-19 severity.	Iron	130-134	hepcidin antimicrobial peptide	Homo sapiens	112-120
35558525-12	2022	Further studies are needed to verify whether targeting the hepcidin-mediated iron metabolism axis may influence the outcome and treatment of COVID-19.	Iron	77-81	hepcidin antimicrobial peptide	Homo sapiens	59-67
35460388-4	2022	Hepcidin is a key regulator of systemic iron balance and acts in harmony with intracellular iron metabolism.	Iron	40-44	hepcidin antimicrobial peptide	Homo sapiens	0-8
34990508-3	2022	Interestingly, the intestinal response to anemia is very similar to that of iron overload disorders, as both the conditions activate a transcriptional program that leads to a hyperabsorption of iron via the transcription factor hypoxia-inducible factor (HIF)2a.	Iron	76-80	endothelial PAS domain protein 1	Mus musculus	228-260
34990508-3	2022	Interestingly, the intestinal response to anemia is very similar to that of iron overload disorders, as both the conditions activate a transcriptional program that leads to a hyperabsorption of iron via the transcription factor hypoxia-inducible factor (HIF)2a.	Iron	194-198	endothelial PAS domain protein 1	Mus musculus	228-260
34990508-6	2022	Our work demonstrates that NCOA4-mediated intestinal ferritinophagy is integrated to systemic iron demand via HIF2a.	Iron	94-98	endothelial PAS domain protein 1	Mus musculus	110-115
34990508-7	2022	To demonstrate the importance of intestinal HIF2a/ferritinophagy axis in systemic iron homeostasis, whole body and intestine-specific NCOA4-null mouse lines were generated and assessed.	Iron	82-86	endothelial PAS domain protein 1	Mus musculus	44-49
35387450-3	2022	Iron catalysts are utilized to accelerate the reaction, but high temperatures and pressures of atmospheric nitrogen gas (N2) and hydrogen gas (H2) are required.	Iron	0-4	gastrin	Homo sapiens	116-119
35278406-11	2022	In addition, IONP@PTX inhibited the capacity of cell migration and invasion, increased the levels of iron ions, ROS and lipid peroxidation, enhanced the expression of autophagy-related protein Beclin1 and LC3II, and suppressed the expression of p62 and ferroptosis-related protein GPX4 in vitro compared with control group.	Iron	101-105	glutathione peroxidase 4	Homo sapiens	281-285
35456688-1	2022	The iron-binding protein lactoferrin and the cell-penetrating peptides derived from its sequence utilise endocytosis to enter different cell types.	Iron	4-8	lactotransferrin	Bos taurus	25-36
35454398-2	2022	It is necessary to analyze the reductive deposition behavior of iron-based materials to Se(IV) and Se(VI) in groundwater.	Iron	64-68	squalene epoxidase	Homo sapiens	88-90
35454398-2	2022	It is necessary to analyze the reductive deposition behavior of iron-based materials to Se(IV) and Se(VI) in groundwater.	Iron	64-68	squalene epoxidase	Homo sapiens	99-101
35484422-3	2022	Here we show that MYCN induces massive lipid peroxidation on depletion of cysteine, the rate-limiting amino acid for glutathione (GSH) biosynthesis, and sensitizes cells to ferroptosis, an oxidative, non-apoptotic and iron-dependent type of cell death.	Iron	218-222	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	18-22
35338344-7	2022	The knockdown of TfR1 and treatment with an inhibitor of FGFR2 caused significant impairment in iron uptake and suppression of cellular proliferation in vitro.	Iron	96-100	fibroblast growth factor receptor 2	Homo sapiens	57-62
35355650-12	2022	The positive association between serum ferritin and Cp at 0.5 to 6 months postpartum may be necessary to increase liver iron release and erythropoiesis after childbirth.	Iron	120-124	ceruloplasmin	Homo sapiens	52-54
35089637-7	2022	Knockdown of PCBP2 but not PCBP1 significantly decreased both TfR1 and FTH expression in MM cells with inhibition of proliferation, indicating stagnation of intracellular iron transport.	Iron	171-175	poly(rC) binding protein 2	Rattus norvegicus	13-18
35378780-1	2022	Purpose: Ferritin is a protein that plays an important role in iron metabolism, it consists of two subunits: heavy chain (FTH) and light chain (FTL).	Iron	63-67	ferritin heavy chain 1	Homo sapiens	122-125
35351859-7	2022	Succinate levels were significantly reduced following treatment with inhibitors of succinate dehydrogenase (SDH), purine nucleotide cycle (PNC), and malate/aspartate shuttle (MAS), with the corresponding attenuation of oxidative stress, iron stress, neuronal damage, and cognitive impairment.	Iron	237-241	aminoadipate-semialdehyde synthase	Mus musculus	108-111
35293225-3	2022	There is now mounting evidence suggesting that tau phosphorylation may be regulated by metal ions (such as iron, zinc and copper), which themselves are implicated in ageing and neurodegenerative disorders such as Alzheimer"s disease (AD).	Iron	107-111	microtubule associated protein tau	Homo sapiens	47-50
35416174-3	2022	3-Hydroxybutyrate dehydrogenase type 2 (BDH2), a rate-limiting catalyzer in the regulation of intracellular iron metabolism and siderophore biogenesis, has been shown to be a tumor suppressor through promotion of cell apoptosis and autophagy.	Iron	108-112	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	0-38
35416174-3	2022	3-Hydroxybutyrate dehydrogenase type 2 (BDH2), a rate-limiting catalyzer in the regulation of intracellular iron metabolism and siderophore biogenesis, has been shown to be a tumor suppressor through promotion of cell apoptosis and autophagy.	Iron	108-112	3-hydroxybutyrate dehydrogenase 2	Homo sapiens	40-44
35038358-0	2022	Drosophila ZIP13 overexpression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria.	Iron	115-119	PTEN-induced putative kinase 1	Drosophila melanogaster	91-96
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	PTEN-induced putative kinase 1	Drosophila melanogaster	48-69
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	PTEN-induced putative kinase 1	Drosophila melanogaster	71-76
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	PTEN-induced putative kinase 1	Drosophila melanogaster	462-467
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	327-331	PTEN-induced putative kinase 1	Drosophila melanogaster	48-69
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	327-331	PTEN-induced putative kinase 1	Drosophila melanogaster	71-76
35295653-7	2022	Compared with no TNF-alpha stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-alpha; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-alpha treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 microg/mL treating MAECs.	Iron	180-182	vascular cell adhesion molecule 1	Mus musculus	40-46
35295653-7	2022	Compared with no TNF-alpha stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-alpha; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-alpha treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 microg/mL treating MAECs.	Iron	294-296	vascular cell adhesion molecule 1	Mus musculus	40-46
35295653-7	2022	Compared with no TNF-alpha stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-alpha; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-alpha treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 microg/mL treating MAECs.	Iron	341-343	vascular cell adhesion molecule 1	Mus musculus	40-46
35269805-9	2022	Indeed, anti-Colony Stimulating Factor 1 Receptor (CSF1R)-mediated depletion of KCs resulted in elevated serum iron levels and impaired iron uptake by the liver.	Iron	111-115	colony stimulating factor 1 receptor	Mus musculus	8-49
35269805-9	2022	Indeed, anti-Colony Stimulating Factor 1 Receptor (CSF1R)-mediated depletion of KCs resulted in elevated serum iron levels and impaired iron uptake by the liver.	Iron	111-115	colony stimulating factor 1 receptor	Mus musculus	51-56
35269805-9	2022	Indeed, anti-Colony Stimulating Factor 1 Receptor (CSF1R)-mediated depletion of KCs resulted in elevated serum iron levels and impaired iron uptake by the liver.	Iron	136-140	colony stimulating factor 1 receptor	Mus musculus	8-49
35269805-9	2022	Indeed, anti-Colony Stimulating Factor 1 Receptor (CSF1R)-mediated depletion of KCs resulted in elevated serum iron levels and impaired iron uptake by the liver.	Iron	136-140	colony stimulating factor 1 receptor	Mus musculus	51-56
35107339-4	2022	Sef1 regulates iron uptake and iron utilization genes under low-iron conditions, leading us to hypothesize that there exists a link between iron availability and contact-dependent invasive filamentation.	Iron	15-19	Sef1p	Saccharomyces cerevisiae S288C	0-4
35107339-4	2022	Sef1 regulates iron uptake and iron utilization genes under low-iron conditions, leading us to hypothesize that there exists a link between iron availability and contact-dependent invasive filamentation.	Iron	31-35	Sef1p	Saccharomyces cerevisiae S288C	0-4
35107339-4	2022	Sef1 regulates iron uptake and iron utilization genes under low-iron conditions, leading us to hypothesize that there exists a link between iron availability and contact-dependent invasive filamentation.	Iron	140-144	Sef1p	Saccharomyces cerevisiae S288C	0-4
35107339-8	2022	Because Sef1 is normally activated in low-iron environments, we embedded WT and dfi1 null cells in iron-free agar medium supplemented with various concentrations of ferrous ammonium sulfate (FAS).	Iron	42-46	Sef1p	Saccharomyces cerevisiae S288C	8-12
35107339-17	2022	Increased expression of Sef1-dependent iron uptake genes as a result of contact-dependent signaling will promote the adaptation of C. albicans cells to a low-iron-availability environment.	Iron	39-43	Sef1p	Saccharomyces cerevisiae S288C	24-28
35107339-17	2022	Increased expression of Sef1-dependent iron uptake genes as a result of contact-dependent signaling will promote the adaptation of C. albicans cells to a low-iron-availability environment.	Iron	158-162	Sef1p	Saccharomyces cerevisiae S288C	24-28
35216492-0	2022	Ferritinophagy and alpha-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson"s Disease.	Iron	86-90	synuclein alpha	Homo sapiens	19-34
35216492-3	2022	A triad contribution of alpha-synuclein aggregation, iron accumulation, and mitochondrial dysfunction plague nigral neurons, yet the events underlying iron accumulation are poorly understood.	Iron	151-155	synuclein alpha	Homo sapiens	24-39
35216492-7	2022	The scope of this review is to describe the physiological and pathological relationship between iron regulation and alpha-synuclein, providing a detailed understanding of iron metabolism within nigral neurons.	Iron	96-100	synuclein alpha	Homo sapiens	116-131
35063650-5	2022	This was confirmed by the findings that AC not only decreased solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) expression but also induced iron- and ROS-dependent aggrandized lipid ROS accumulation and plasma membrane damage.	Iron	170-174	solute carrier family 7 member 11	Homo sapiens	62-95
35265813-0	2022	Adipose triglyceride lipase mediates lipolysis and lipid mobilization in response to iron-mediated negative energy balance.	Iron	85-89	patatin-like phospholipase domain containing 2	Mus musculus	0-27
35265813-7	2022	In response to dietary iron-induced negative energy balance, adipose triglyceride lipase (ATGL) was necessary for wasting of subcutaneous white adipose tissue and lipid mobilization.	Iron	23-27	patatin-like phospholipase domain containing 2	Mus musculus	61-88
35265813-7	2022	In response to dietary iron-induced negative energy balance, adipose triglyceride lipase (ATGL) was necessary for wasting of subcutaneous white adipose tissue and lipid mobilization.	Iron	23-27	patatin-like phospholipase domain containing 2	Mus musculus	90-94
35167013-1	2022	The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH) and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron homeostasis.	Iron	169-173	ceruloplasmin	Homo sapiens	46-59
35167013-1	2022	The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH) and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron homeostasis.	Iron	169-173	ceruloplasmin	Homo sapiens	61-63
35167013-5	2022	CP is particularly important in facilitating iron release from the liver and central nervous system, HEPH is the major MCF in the small intestine and is critical for dietary iron absorption, and ZP is important for normal hair development.	Iron	45-49	ceruloplasmin	Homo sapiens	0-2
35172141-0	2022	Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological alpha-synuclein.	Iron	38-42	synuclein alpha	Homo sapiens	85-100
35048936-0	2022	The controlled synthesis of nitrogen and iron co-doped Ni3S2@NiP2 heterostructures for the oxygen evolution reaction and urea oxidation reaction.	Iron	41-45	BCL2 interacting protein 2	Homo sapiens	61-65
35048936-2	2022	Herein, nitrogen and iron co-doped Ni3S2 and NiP2 heterostructures with high efficiency oxygen evolution reaction (OER) and urea oxidation reaction (UOR) performances were firstly successfully prepared on nickel foam by hydrothermal and high-temperature calcination methods.	Iron	21-25	BCL2 interacting protein 2	Homo sapiens	45-49
35136051-1	2022	MitoNEET (mitochondrial protein containing Asn-Glu-Glu-Thr (NEET) sequence) is a 2Fe-2S cluster-containing integral membrane protein that resides in the mitochondrial outer membrane and participates in a redox-sensitive signaling and Fe-S cluster transfer.	Iron	234-236	CDGSH iron sulfur domain 1	Homo sapiens	0-8
35136051-1	2022	MitoNEET (mitochondrial protein containing Asn-Glu-Glu-Thr (NEET) sequence) is a 2Fe-2S cluster-containing integral membrane protein that resides in the mitochondrial outer membrane and participates in a redox-sensitive signaling and Fe-S cluster transfer.	Iron	234-236	CDGSH iron sulfur domain 1	Homo sapiens	60-64
35136051-2	2022	Thus, mitoNEET is a key regulator of mitochondrial oxidative capacity and iron homeostasis.	Iron	74-78	CDGSH iron sulfur domain 1	Homo sapiens	6-14
35160288-3	2022	The purpose of this study was to assess iron-related proteins in non-failing (NFH) vs. failing (FH) human myocardium.	Iron	40-44	neurofilament heavy chain	Homo sapiens	78-81
35218933-3	2022	Thus, in response to iron deficiency, transcription factors Aft1 and Aft2 activate the expression of genes implicated in iron acquisition and mobilization, whereas two mRNA-binding proteins, Cth1 and Cth2, posttranscriptionally control iron metabolism.	Iron	236-240	Tis11p	Saccharomyces cerevisiae S288C	200-204
34988569-6	2022	The released iron-chelating drug and sorafenib not only produce hydroxyl radicals ( OH) to induce ferroptosis, but also inhibit the expression of GPX4 to mitigate the ferroptosis resistance.	Iron	13-17	glutathione peroxidase 4	Mus musculus	146-150
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	173-181
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	84-88	hepcidin antimicrobial peptide	Homo sapiens	183-187
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	173-181
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	140-144	hepcidin antimicrobial peptide	Homo sapiens	183-187
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	140-144	solute carrier family 40 member 1	Homo sapiens	237-244
35128083-7	2022	Gd3+ caused iron accumulation around the white pulp of the spleen, suggesting that enlargement of the spleen is, at least in part, associated with Gd3+ and/or iron accumulation.	Iron	12-16	GRDX	Homo sapiens	0-3
35128083-7	2022	Gd3+ caused iron accumulation around the white pulp of the spleen, suggesting that enlargement of the spleen is, at least in part, associated with Gd3+ and/or iron accumulation.	Iron	159-163	GRDX	Homo sapiens	0-3
35077390-6	2022	Downregulated of TEAD2 could promote the death of HCC cells through inducing ferroptosis by iron accumulation and subsequent oxidative damage.	Iron	92-96	TEA domain transcription factor 2	Homo sapiens	17-22
35064352-0	2022	BioMIPs: molecularly imprinted silk fibroin nanoparticles to recognize the iron regulating hormone hepcidin.	Iron	75-79	hepcidin antimicrobial peptide	Homo sapiens	99-107
35064352-2	2022	Here, we attempted the imprinting of fibroin-based molecularly imprinted polymers (MIPs), called bioMIPs, using as a template hepcidin that is a iron-metabolism regulator-peptide, possessing a hairpin structure.	Iron	145-149	hepcidin antimicrobial peptide	Homo sapiens	126-134
35079622-8	2022	This excessive iron accumulation was absent from FDX2 affected muscle and could not be correlated with variable gene expression in muscle cells.	Iron	15-19	ferredoxin 2	Homo sapiens	49-53
35079622-9	2022	Discussion: We conclude that FDX2 and ISCU variants result in a similar muscle phenotype, that differ in severity and skeletal muscle iron accumulation.	Iron	134-138	ferredoxin 2	Homo sapiens	29-33
35204067-8	2022	As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women.	Iron	7-11	doublesex and mab-3 related transcription factor 1	Homo sapiens	60-64
35204067-8	2022	As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women.	Iron	7-11	solute carrier family 40 member 1	Homo sapiens	66-79
35118074-4	2021	We identified the prognostic value of two iron metabolism-related genes (SLC39A8 (encoding solute carrier family 39 member 8) and SLC48A1 (encoding solute carrier family 48 member 1)) in COAD.	Iron	42-46	solute carrier family 48 member 1	Homo sapiens	148-181
35118074-7	2021	This study verified that the iron metabolism-related gene signature (SLC39A8 and SLC48A1) could be used as a prognostic biomarker for patients with COAD.	Iron	29-33	solute carrier family 48 member 1	Homo sapiens	81-88
35174317-1	2022	Ferroptosis is an iron-dependent, oxidative form of cell death that is countered mainly by glutathione peroxidase 4 (GPX4) and the production of glutathione (GSH), which is formed from cysteine.	Iron	18-22	glutathione peroxidase 4	Homo sapiens	91-115
35174317-1	2022	Ferroptosis is an iron-dependent, oxidative form of cell death that is countered mainly by glutathione peroxidase 4 (GPX4) and the production of glutathione (GSH), which is formed from cysteine.	Iron	18-22	glutathione peroxidase 4	Homo sapiens	117-121
35174317-4	2022	MYCN increases iron metabolism and subsequent hydroxyl radicals through increased expression of the transferrin receptor 1 (TfR1) and low levels of the ferroportin receptor.	Iron	15-19	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
35022042-4	2022	METHODS: Intra- and extracellular iron was measured in cell-line-derived and in freshly isolated sputum macrophages under various experimental conditions including treatment with exogenous IL-6 and hepcidin.	Iron	34-38	hepcidin antimicrobial peptide	Homo sapiens	198-206
35022042-8	2022	IL-6 and hepcidin play roles in pulmonary iron sequestration, though IL-6 appears to exert its effect via a hepcidin-independent mechanism.	Iron	42-46	hepcidin antimicrobial peptide	Homo sapiens	9-17
35417944-3	2022	RESULTS: In the substantia nigra of PD patients, in comparison with the control, a stable accumulation of pathological alpha-synuclein (alpha-Syn-p129) in the bodies and processes of neurons was found, and in the neuroglia and neuropil - the accumulation of iron (II) and ferritin heavy chain, the reaction of microglia to protein CD68 was moderately elevated.	Iron	258-262	synuclein alpha	Homo sapiens	119-134
35417944-6	2022	Excessive accumulation of the ferritin heavy chain in neuroglia can increase the concentration of reactive forms of iron and increase neurotoxicity.	Iron	116-120	ferritin heavy chain 1	Homo sapiens	30-50
35125723-0	2022	Impact of HFE-2 and HAMP Gene Variations on Iron Overload in Pediatric Patients with Non-Transfusion Dependent Thalassemia: A Pilot Study.	Iron	44-48	hemojuvelin BMP co-receptor	Homo sapiens	10-15
35125723-0	2022	Impact of HFE-2 and HAMP Gene Variations on Iron Overload in Pediatric Patients with Non-Transfusion Dependent Thalassemia: A Pilot Study.	Iron	44-48	hepcidin antimicrobial peptide	Homo sapiens	20-24
35125723-2	2022	Possible genes which may be implicated in causing iron overload are hepcidin (HAMP) and hemojuvelin (HFE).	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	68-76
35125723-2	2022	Possible genes which may be implicated in causing iron overload are hepcidin (HAMP) and hemojuvelin (HFE).	Iron	50-54	hepcidin antimicrobial peptide	Homo sapiens	78-82
35125723-2	2022	Possible genes which may be implicated in causing iron overload are hepcidin (HAMP) and hemojuvelin (HFE).	Iron	50-54	hemojuvelin BMP co-receptor	Homo sapiens	88-99
35125723-11	2022	Presence of SNV p.Gln315Argin HFE-2 gene needs to be evaluated in larger sample sizes in our population to determine the incidence in homozygous state and its association with iron overload.	Iron	176-180	hemojuvelin BMP co-receptor	Homo sapiens	30-35
35124661-0	2022	Early-Onset Parkinson"s Disease and Brain Iron Accumulation Caused by a Novel Homozygous DJ-1 Mutation.	Iron	42-46	Parkinsonism associated deglycase	Homo sapiens	89-93
35233284-3	2022	Results: Omentin-1 levels in HD were statistically higher than in healthy controls (P = 0.03) and there was a significant, growing trend in all iron parameters across Omentin-1 tertiles (P < 0.001).	Iron	144-148	intelectin 1	Homo sapiens	167-174
2808397-5	1989	Activation volumes for O2 to the iron binding step as well as for the O2 diffusion step within the protein matrix were quite different among three Mb species, and it was suggested that activation volumes are very sensitive to the amino acid constituents around the ligand path channel.	Iron	33-37	myoglobin	Canis lupus familiaris	147-149
2804139-7	1989	Of the metalloporphyrins examined (Fe, Co, Zn and Sn) all inhibited ferrochelatase at micromolar concentrations, although tin protoporphyrin was the least effective.	Iron	35-37	ferrochelatase	Mus musculus	68-82
2605128-1	1989	Haemin inhibited iron uptake from transferrin (Tf) by mouse erythroleukaemia cells (MELC) induced for differentiation by hexamethylene bisacetamide (HMBA).	Iron	17-21	transferrin	Mus musculus	34-45
2605128-1	1989	Haemin inhibited iron uptake from transferrin (Tf) by mouse erythroleukaemia cells (MELC) induced for differentiation by hexamethylene bisacetamide (HMBA).	Iron	17-21	transferrin	Mus musculus	47-49
2483680-1	1989	The proton spin-lattice relaxation time T1 in iron-doped serum was measured with a magnetic resonance imager operating at 0.5 T. The T1 in aqueous solutions of iron and iron-doped solutions of albumin and gamma globulin was also measured in order to analyse the paramagnetic contribution in iron-doped serum.	Iron	46-50	spindlin 1	Homo sapiens	11-15
2812898-5	1989	The insulin-infused group had a lower mean plasma iron concentration (20.8 +/- 10.9 versus 42.1 +/- 14.7 microM/L; p less than 0.02) and total iron-binding capacity saturation (36 +/- 20 versus 64 +/- 22%; p less than 0.02) and a higher total red cell Hb (45.4 +/- 8.7 versus 32.6 +/- 8.8 g; p less than 0.02) and total red cell iron content (154 +/- 29 versus 111 +/- 29 mg; p less than 0.02) when compared with the placebo group.	Iron	50-54	LOC105613195	Ovis aries	4-11
2812898-5	1989	The insulin-infused group had a lower mean plasma iron concentration (20.8 +/- 10.9 versus 42.1 +/- 14.7 microM/L; p less than 0.02) and total iron-binding capacity saturation (36 +/- 20 versus 64 +/- 22%; p less than 0.02) and a higher total red cell Hb (45.4 +/- 8.7 versus 32.6 +/- 8.8 g; p less than 0.02) and total red cell iron content (154 +/- 29 versus 111 +/- 29 mg; p less than 0.02) when compared with the placebo group.	Iron	143-147	LOC105613195	Ovis aries	4-11
2812898-5	1989	The insulin-infused group had a lower mean plasma iron concentration (20.8 +/- 10.9 versus 42.1 +/- 14.7 microM/L; p less than 0.02) and total iron-binding capacity saturation (36 +/- 20 versus 64 +/- 22%; p less than 0.02) and a higher total red cell Hb (45.4 +/- 8.7 versus 32.6 +/- 8.8 g; p less than 0.02) and total red cell iron content (154 +/- 29 versus 111 +/- 29 mg; p less than 0.02) when compared with the placebo group.	Iron	143-147	LOC105613195	Ovis aries	4-11
2798217-2	1989	It was found that the macrophages of these brains expressed a lysosomal tartrate-resistant acid phosphatase which gave a good immunological cross-reaction with an antibody to the well-characterized iron-containing bovine spleen purple acid phosphatase, belonging to the group of purple phosphatases, which are regarded as a marker for a special phenotype of activated macrophages.	Iron	198-202	acid phosphatase 5, tartrate resistant	Homo sapiens	228-251
2524277-11	1989	As well as showing that the initial intrasynovial event in collagen arthritis is perivascular infiltration by members of the CD4+ T cell subset displaying a phenotypic sign of activation, these findings demonstrate that iron administered at a critical time after immunization enhances the induction of collagen arthritis.	Iron	220-224	Cd4 molecule	Rattus norvegicus	125-128
9948073-0	1989	Spin disorder in paramagnetic fcc iron.	Iron	34-38	spindlin 1	Homo sapiens	0-4
2548593-6	1989	Evidence for the production of hydroxyl radical during iron-catalyzed oxidation of VP-16 catechol was obtained.	Iron	55-59	host cell factor C1	Homo sapiens	83-88
2539041-9	1989	In contrast with other diheme cytochrome c peroxidases, reduction of the low-spin heme was not necessary to permit ligand binding by the high-spin heme iron.	Iron	152-156	cytochrome c3 family protein	Pseudomonas stutzeri	30-42
2642388-1	1989	Various types of proliferating cell are known to express transferrin receptors which are necessary for transferrin-mediated cellular iron uptake.	Iron	133-137	transferrin	Mus musculus	57-68
2642388-1	1989	Various types of proliferating cell are known to express transferrin receptors which are necessary for transferrin-mediated cellular iron uptake.	Iron	133-137	transferrin	Mus musculus	103-114
2642388-8	1989	Since transferrin receptor levels remain high during lactation they are not associated solely with tissue growth, but may also function in transporting iron during milk production.	Iron	152-156	transferrin	Mus musculus	6-17
2618593-6	1989	Indeed H2O2 derived from MAO B reaction and autooxidation of dopamine to melanin in the SN can drive the iron dependent Fenton reaction.	Iron	105-109	monoamine oxidase B	Homo sapiens	25-30
3262656-9	1988	The PC-1 glycoprotein was also found in the capillaries of the brain, but did not appear to be present in capillaries elsewhere, a pattern that is strikingly similar to that of the receptor for the iron transport protein, transferrin.	Iron	198-202	minisatellite 6 hypermutable	Mus musculus	4-8
3136803-1	1988	The iron coordination in native, Fe(II), lipoxygenase has been studied by Extended X-Ray Absorption Fine Structure (EXAFS).	Iron	4-8	linoleate 9S-lipoxygenase-4	Glycine max	33-53
16347658-12	1988	GS-15 provides a model for how enzymatically catalyzed reactions can be quantitatively significant mechanisms for the reduction of iron and manganese in anaerobic environments.	Iron	131-135	Bet1 golgi vesicular membrane trafficking protein like	Homo sapiens	0-5
3402348-6	1988	Iron status was markedly different in the GAA-treated rats at the end of the 16 week treatment period, suggesting altered iron utilization.	Iron	0-4	alpha glucosidase	Rattus norvegicus	42-45
3402348-6	1988	Iron status was markedly different in the GAA-treated rats at the end of the 16 week treatment period, suggesting altered iron utilization.	Iron	122-126	alpha glucosidase	Rattus norvegicus	42-45
2841676-1	1988	Cytochrome c peroxidase, freshly prepared, contains a penta-coordinated heme iron and is fully reactive with hydroperoxides.	Iron	77-81	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	0-23
2841676-4	1988	Thus, the reactivity of cytochrome c peroxidase with hydroperoxides is strongly controlled by the coordination state of the heme iron.	Iron	129-133	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	24-47
3607227-4	1987	We then investigate the field strength dependence of the acid-alkaline transition, i.e., the hydrolysis reaction of the water coordinated to the heme iron, in metmyoglobin and methemoglobin.	Iron	150-154	hemoglobin subunit gamma 2	Homo sapiens	176-189
3031158-15	1987	The reaction could also be inhibited by superoxide dismutase and azide, indicating that O-2 and heme or an iron-dependent enzyme were required for the reaction.	Iron	107-111	immunoglobulin kappa variable 1D-39	Homo sapiens	88-91
3028266-2	1987	The enzyme is a yellowish brown iron-sulfur protein, containing four nonheme iron and labile sulfide groups, that catalyzes the activation of NADP-malate dehydrogenase and fructose 1,6-bisphosphatase in the presence of ferredoxin and of thioredoxin m and f, respectively.	Iron	32-36	LOC101027257	Zea mays	237-248
3454117-7	1987	The best characterized is uteroferrin, a purple colored, iron-containing acid phosphatase which transports iron across the placenta.	Iron	57-61	acid phosphatase 5, tartrate resistant	Sus scrofa	26-37
3438254-2	1987	It as been proposed that the physiological function of ceruloplasmin involves the oxidation of ferrous iron and its incorporation into apotransferrin.	Iron	95-107	ceruloplasmin	Equus caballus	55-68
3671428-4	1987	In the case of transferrin, the major iron-binding protein of mouse milk, the ECM rather than prolactin, appears to modulate the level of its mRNA.	Iron	38-42	transferrin	Mus musculus	15-26
24214093-0	1986	Hydrogeochemical studies for Al, F and Fe in waters supplying haemodialysis units in the Trent region, U.K. Geographical and seasonal variations in the concentrations of Al, F and Fe in tap water supplying home haemodialysis units within the administrative area of the Trent Regional Health Authority, have been examined.	Iron	180-182	nuclear RNA export factor 1	Homo sapiens	186-189
3768410-1	1986	Addition of iron-binding proteins (human serum transferrin, mouse serum transferrin, human lactoferrin) to the luminal fluid in tied-off segments of mouse intestine in vivo led to reduced 59Fe3+ absorption from 59Fe3+-nitrilotriacetate when compared to 59Fe3+-nitrilotriacetate alone.	Iron	12-16	transferrin	Mus musculus	47-58
3768410-1	1986	Addition of iron-binding proteins (human serum transferrin, mouse serum transferrin, human lactoferrin) to the luminal fluid in tied-off segments of mouse intestine in vivo led to reduced 59Fe3+ absorption from 59Fe3+-nitrilotriacetate when compared to 59Fe3+-nitrilotriacetate alone.	Iron	12-16	transferrin	Mus musculus	72-83
3099540-1	1986	Role of unbound iron binding capacity of transferrin.	Iron	16-20	transferrin	Mus musculus	41-52
9940240-0	1986	Spin delocalization of interstitial iron in silicon.	Iron	36-40	spindlin 1	Homo sapiens	0-4
16665060-4	1986	Since Fe stress-induced acidification is diminished by vanadate and erythrosin B, both specific inhibitors of plasmalemma ATPases, it seems reasonable to suppose that H(+) pumping from transfer cells is activated by an ATPase located in their plasmamembrane.	Iron	6-8	aTP-dependent zinc metalloprotease FTSH, chloroplastic	Capsicum annuum	122-128
3791352-1	1986	Myoglobin, an intracellular iron containing protein that binds oxygen reversibly, has been shown in model systems to facilitate the diffusion of oxygen and thereby maintain the mechanical function of exercising canine skeletal muscle and of hypoxic benthic fish hearts.	Iron	28-32	myoglobin	Canis lupus familiaris	0-9
3707999-0	1986	Effect of decreased ferrochelatase activity on iron and porphyrin content in mitochondria of mice with porphyria induced by griseofulvin.	Iron	47-51	ferrochelatase	Mus musculus	20-34
3006043-1	1986	Yeast cytochrome c peroxidase reacts with hydrogen peroxide to form an intermediate, compound ES, in which the heme iron atom is converted to a ferryl function (Fe4+ = O) and a radical center is generated on a reversibly oxidizable amino acid residue of uncertain identity.	Iron	116-120	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	6-29
6601454-7	1983	Ferric chloride and iron saturated mouse transferrin did not restore the response to either Con A or lipopolysaccharide.	Iron	20-24	transferrin	Mus musculus	41-52
6822435-2	1983	The plasma transferrin iron pool of normal mice was found to be very dynamic, with a half-life of iron in the pool of 0.7 h. Iron left the plasma pool, entered the bone marrow, and was released into the blood in erythrocytes.	Iron	23-27	transferrin	Mus musculus	11-22
6822435-2	1983	The plasma transferrin iron pool of normal mice was found to be very dynamic, with a half-life of iron in the pool of 0.7 h. Iron left the plasma pool, entered the bone marrow, and was released into the blood in erythrocytes.	Iron	98-102	transferrin	Mus musculus	11-22
6822435-2	1983	The plasma transferrin iron pool of normal mice was found to be very dynamic, with a half-life of iron in the pool of 0.7 h. Iron left the plasma pool, entered the bone marrow, and was released into the blood in erythrocytes.	Iron	125-129	transferrin	Mus musculus	11-22
6822435-3	1983	Iron from the transferrin pool also entered the liver and spleen and was presumably in the reticuloendothelial system components of these organs.	Iron	0-4	transferrin	Mus musculus	14-25
6822435-4	1983	Most of the iron that had been supplied as transferrin iron was found in erythrocytes by 48 h after injection.	Iron	12-16	transferrin	Mus musculus	43-54
6822435-4	1983	Most of the iron that had been supplied as transferrin iron was found in erythrocytes by 48 h after injection.	Iron	55-59	transferrin	Mus musculus	43-54
6822435-7	1983	Iron turnover in the plasma transferrin pool during the hypoferremic phase was similar to control rates, and iron leaving the pool entered its normal erythroid compartments.	Iron	0-4	transferrin	Mus musculus	28-39
6822435-9	1983	Our evidence has implicated an impaired return of reticuloendothelial system-processed iron to the transferrin pool during the hypoferremic response.	Iron	87-91	transferrin	Mus musculus	99-110
6822435-10	1983	This appears to be a logical point in the erythroid iron cycle for host-mediated iron sequestration, as the reticuloendothelial system is involved in iron storage and may regulate iron levels in the plasma transferrin pool under normal conditions.	Iron	52-56	transferrin	Mus musculus	206-217
6822435-10	1983	This appears to be a logical point in the erythroid iron cycle for host-mediated iron sequestration, as the reticuloendothelial system is involved in iron storage and may regulate iron levels in the plasma transferrin pool under normal conditions.	Iron	81-85	transferrin	Mus musculus	206-217
6822435-10	1983	This appears to be a logical point in the erythroid iron cycle for host-mediated iron sequestration, as the reticuloendothelial system is involved in iron storage and may regulate iron levels in the plasma transferrin pool under normal conditions.	Iron	81-85	transferrin	Mus musculus	206-217
6822435-10	1983	This appears to be a logical point in the erythroid iron cycle for host-mediated iron sequestration, as the reticuloendothelial system is involved in iron storage and may regulate iron levels in the plasma transferrin pool under normal conditions.	Iron	81-85	transferrin	Mus musculus	206-217
6617951-1	1983	Human caeruloplasmin (ferroxidase), bovine serum albumin and ascorbate protected washed rat erythrocytes against iron ion stimulated haemolysis, while superoxide dismutase, catalase and other scavengers of "activated oxygen" species had little or no effect.	Iron	113-117	albumin	Rattus norvegicus	43-56
6294082-1	1982	We have studied the spatial relationship between cytochromes a and a3 by the enhancement of the spin relaxation of cytochrome a3-NO EPR signals by the paramagnetic a heme at 15 K. An Fe-Fe distance of 12-19A is estimated from the absence of dipolar broadening and from the observation of spin relaxation enhancement in the a3-NO complex.	Iron	186-188	SLAM family member 7	Homo sapiens	204-207
24272579-0	1982	Ferritin in bean leaves with constant and changing iron status.	Iron	51-55	brain expressed associated with NEDD4 1	Homo sapiens	12-16
6284220-1	1982	Experiments were performed to determine the level of transferrin receptors and rate of transferrin-bound iron uptake by various immature erythroid cell populations.	Iron	105-109	transferrin	Mus musculus	87-98
6284220-7	1982	The rate of iron uptake from transferrin during erythroid cell development was found to correlate closely with the number of transferrin receptors.	Iron	12-16	transferrin	Mus musculus	29-40
6284220-7	1982	The rate of iron uptake from transferrin during erythroid cell development was found to correlate closely with the number of transferrin receptors.	Iron	12-16	transferrin	Mus musculus	125-136
7078081-3	1982	Monkeys homozygous for the Tf-D or Tf-G alleles were found to have higher total iron binding capacities and lower serum total iron levels than those homozygous for the Tf-C allele.	Iron	80-84	trafficking from ER to golgi regulator	Macaca mulatta	35-39
7078081-3	1982	Monkeys homozygous for the Tf-D or Tf-G alleles were found to have higher total iron binding capacities and lower serum total iron levels than those homozygous for the Tf-C allele.	Iron	126-130	trafficking from ER to golgi regulator	Macaca mulatta	35-39
6255999-2	1980	Prolyl 4-hydroxylase (prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, EC 1.14.11.2) was isolated in a form containing iron (0.85-1.1 mol Fe/mol enzyme).	Iron	131-135	thioredoxin reductase 1	Homo sapiens	67-81
7188938-3	1980	When saturated, pairs of the approximately 135 phosphate groups of a phosvitin molecule appear to bind 1 iron atom each.	Iron	105-109	3-hydroxyacyl-CoA dehydratase 3	Homo sapiens	98-104
7354807-3	1980	We measured the activities of protoporphyrinogen oxidase, which catalyzes the oxidation of protoporphyrinogen to protoporphyrin, and heme synthase, which catalyzes the chelation of iron to protoporphyrins, in cultured skin fibroblasts from five normal controls and five patients with variegate porphyria.	Iron	181-185	ferrochelatase	Homo sapiens	133-146
7353040-1	1980	Ionization and orientation of iron-bound imidazole in methemoglobin and metmyoblobin.	Iron	30-34	hemoglobin subunit gamma 2	Homo sapiens	54-67
7356682-1	1980	Heme synthase (ferrochelatase) activity, as determined by the chelation of ferrous iron to protoporphyrin or deuteroporphyrin, is reduced to 10-25% of normal in tissues of patients with protoporphyria.	Iron	75-87	ferrochelatase	Homo sapiens	0-13
7356682-1	1980	Heme synthase (ferrochelatase) activity, as determined by the chelation of ferrous iron to protoporphyrin or deuteroporphyrin, is reduced to 10-25% of normal in tissues of patients with protoporphyria.	Iron	75-87	ferrochelatase	Homo sapiens	15-29
7352984-2	1980	The NMR spectra show that the heme methyl proton resonances from the beta subunits in methemoglobin were selectively affected by the binding of pMB regardless of whether the heme iron was saturated with high-spin or low-spin ligand.	Iron	179-183	hemoglobin subunit gamma 2	Homo sapiens	86-99
7352984-5	1980	A model study of the azide-methemoglobin complex suggested that the increase of the high-spin character of the beta heme iron is due to a conformational change of the proximal histidine which weakens the interaction between the heme iron and the proximal base.	Iron	121-125	hemoglobin subunit gamma 2	Homo sapiens	27-40
7352984-5	1980	A model study of the azide-methemoglobin complex suggested that the increase of the high-spin character of the beta heme iron is due to a conformational change of the proximal histidine which weakens the interaction between the heme iron and the proximal base.	Iron	233-237	hemoglobin subunit gamma 2	Homo sapiens	27-40
533878-3	1979	Iron-binding properties were determined, and the ability to remove iron from the proteins transferrin and ferritin was ascertained.	Iron	67-71	transferrin	Mus musculus	90-101
440897-1	1979	A 5-month-old infant with hypochromic anemia and iron overload secondary to ferrochelatase (heme synthetase) deficiency is described.	Iron	49-53	ferrochelatase	Homo sapiens	76-90
281250-1	1978	Iron uptake from 55Fe-labelled transferrin, ferric citrate and the two fungal sideramines, ferricrocin and fusigen was studied using four erythroid cell cultures: Friend virus-transformed erythroleukemic cells (mouse), transformed bone marrow cells, Detroit-98 (human), reticulocytes (bovine), bone marrow cells (rabbit).	Iron	0-4	transferrin	Mus musculus	31-42
365761-1	1978	The fate of virulent and avirulent strains of Salmonella typhimurium in untreated and iron-injected mice and in transferrin-containing media demonstrated a direct relationship between bacterial virulence and the ability of bacteria to acquire transferrin-bound iron.	Iron	86-90	transferrin	Mus musculus	243-254
365761-1	1978	The fate of virulent and avirulent strains of Salmonella typhimurium in untreated and iron-injected mice and in transferrin-containing media demonstrated a direct relationship between bacterial virulence and the ability of bacteria to acquire transferrin-bound iron.	Iron	261-265	transferrin	Mus musculus	243-254
667106-2	1978	The different features of the nature of heme iron-proximal binding in methemoglobin and metmyoglobin were investigated by high resolution proton nuclear magnetic resonance spectroscopy at 220 MHz.	Iron	45-49	hemoglobin subunit gamma 2	Homo sapiens	70-83
667106-4	1978	This observation was interpreted in terms of the stronger interaction between proximal histidine and ferric heme iron in methemoglobin than in metmyoglobin.	Iron	113-117	hemoglobin subunit gamma 2	Homo sapiens	121-134
667106-8	1978	From the comparisons between methemoglobin and metmyoglobin, and between the alpha and beta subunits in methemoglobin, the order of the strength of the iron-histidine bond interaction was deduced as follows: metmyoglobin less than alpha subunits in methemoglobin less than or equal to beta units in methemoglobin.	Iron	152-156	hemoglobin subunit gamma 2	Homo sapiens	104-117
667106-8	1978	From the comparisons between methemoglobin and metmyoglobin, and between the alpha and beta subunits in methemoglobin, the order of the strength of the iron-histidine bond interaction was deduced as follows: metmyoglobin less than alpha subunits in methemoglobin less than or equal to beta units in methemoglobin.	Iron	152-156	hemoglobin subunit gamma 2	Homo sapiens	104-117
667106-8	1978	From the comparisons between methemoglobin and metmyoglobin, and between the alpha and beta subunits in methemoglobin, the order of the strength of the iron-histidine bond interaction was deduced as follows: metmyoglobin less than alpha subunits in methemoglobin less than or equal to beta units in methemoglobin.	Iron	152-156	hemoglobin subunit gamma 2	Homo sapiens	104-117
18962187-3	1977	Iron is then recovered by elution with 0.15M hydrochloric acid-1% hydrazine solution.	Iron	0-4	mediator complex subunit 25	Homo sapiens	58-64
144704-0	1977	Use of transferrin-iron enterobactin complexes as the source of iron by serum-exposed bacteria.	Iron	19-23	transferrin	Mus musculus	7-18
144704-0	1977	Use of transferrin-iron enterobactin complexes as the source of iron by serum-exposed bacteria.	Iron	64-68	transferrin	Mus musculus	7-18
144704-6	1977	This failure to use transferrin-iron-E complexes by deep rough strains was found to be due to the inability of these strains to absorb iron containing complexes to their outer membrane.	Iron	32-36	transferrin	Mus musculus	20-31
144704-7	1977	Adsorption studies with chemically treated bacteria showed that the receptor of transferrin-iron-E or E-iron complexes is a protein of the outer membrane of bacterial cells.	Iron	92-96	transferrin	Mus musculus	80-91
144704-7	1977	Adsorption studies with chemically treated bacteria showed that the receptor of transferrin-iron-E or E-iron complexes is a protein of the outer membrane of bacterial cells.	Iron	104-108	transferrin	Mus musculus	80-91
21981-4	1977	The ascorbic acid plus Fe++-stimulated lipid peroxidation produced a decrease in ethylmorphine N-demethylase activity which was closely related to ethylmorphine-enhanced NADPH-cytochrome P-450 reductase activity but was not related to the change of the apparent content of cytochrome P-450 in all animal species.	Iron	23-27	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	170-202
11898-1	1976	Each mole of oxyhemoglobin iron converted to methemoglobin causes the oxidation of 1.5 mol of nitrite to nitrate and consumes 1 mol of protons.	Iron	27-31	hemoglobin subunit gamma 2	Homo sapiens	45-58
941868-8	1976	Substitution of beef, lamb, pork, liver, fish, and chicken for the egg ovalbumin in the sannisynthetic meal resulted in a significant, 2-fold to 4-fold increase in iron absorption whereas no increase was observed with milk, cheese, or egg.	Iron	164-168	ovalbumin (SERPINB14)	Gallus gallus	71-80
182223-3	1976	The observation of a 630 nm band in quantum mixed-spin heme spectra, and the spin state-dependence of the band intensity, are discussed in the context of the iron-ligand structure for quantum mixed-spin heme inferred from magnetic data.	Iron	158-162	spindlin 1	Homo sapiens	50-54
182223-3	1976	The observation of a 630 nm band in quantum mixed-spin heme spectra, and the spin state-dependence of the band intensity, are discussed in the context of the iron-ligand structure for quantum mixed-spin heme inferred from magnetic data.	Iron	158-162	spindlin 1	Homo sapiens	77-81
182223-3	1976	The observation of a 630 nm band in quantum mixed-spin heme spectra, and the spin state-dependence of the band intensity, are discussed in the context of the iron-ligand structure for quantum mixed-spin heme inferred from magnetic data.	Iron	158-162	spindlin 1	Homo sapiens	77-81
818893-0	1976	Food iron absorption in man II.	Iron	5-9	mannosidase alpha class 2A member 1	Homo sapiens	24-30
177310-0	1976	The pattern of iron--sulfur centers in brown adipose tissue mitochondria: preponderance of ETF dehydrogenase and invariance with the thermogenic state.	Iron	15-19	electron transfer flavoprotein dehydrogenase	Homo sapiens	91-108
1083028-0	1976	Novel mechanism for translational control in regulation of ferritin synthesis by iron.	Iron	81-85	Fer2	Triticum aestivum	59-67
1083028-3	1976	Following iron administration, there was a 2-fold increase in the amount of ferritin mRNA in the polyribosomal fraction.	Iron	10-14	Fer2	Triticum aestivum	76-84
1083028-6	1976	When iron was administered, this untranslated ferritin mRNA became reduced to negligible quantities, thus accounting for the doubling of the ferritin mRNA content of the polyribosomal fraction.	Iron	5-9	Fer2	Triticum aestivum	46-54
1083028-6	1976	When iron was administered, this untranslated ferritin mRNA became reduced to negligible quantities, thus accounting for the doubling of the ferritin mRNA content of the polyribosomal fraction.	Iron	5-9	Fer2	Triticum aestivum	141-149
1083028-8	1976	Iron administration removes this inhibition of the translation of ferritin mRNA by promoting aggregation of these subunits into ferritin.	Iron	0-4	Fer2	Triticum aestivum	66-74
1083028-8	1976	Iron administration removes this inhibition of the translation of ferritin mRNA by promoting aggregation of these subunits into ferritin.	Iron	0-4	Fer2	Triticum aestivum	128-136
1085699-4	1976	More thorough removal of A cells by treatment with carbonyl iron powder was required for appreciable reduction of the responses to POL, DNP-Ficoll and "soluble" SRBC.	Iron	60-64	caveolae associated 3	Mus musculus	161-165
171266-7	1975	These effects, which were observed in the absence of iron salts, led to the proposal that O2- and H2O2 can directly give rise to a singlet oxygen, as follows: O2- + H2O2 leads to OH- + OH.	Iron	53-57	immunoglobulin kappa variable 1D-39	Homo sapiens	90-102
1184741-2	1975	The final step in heme biosynthesis is chelation of porphyrin with Fe++ catalyzed by the mitochondrial enzyme heme synthetase.	Iron	67-71	ferrochelatase	Homo sapiens	110-125
810795-4	1975	These flagellates, in the presence of protoporphyrin IX, incorporated 59Fe into heme, indicating that they possess ferrochelatase (EC 4.99.1.1), the terminal enzyme in the heme biosynthetic pathway, which catalyzes the insertion of iron into protoporphyrin IX.	Iron	232-236	ferrochelatase	Homo sapiens	115-129
810795-4	1975	These flagellates, in the presence of protoporphyrin IX, incorporated 59Fe into heme, indicating that they possess ferrochelatase (EC 4.99.1.1), the terminal enzyme in the heme biosynthetic pathway, which catalyzes the insertion of iron into protoporphyrin IX.	Iron	232-236	ferrochelatase	Homo sapiens	131-142
169866-4	1975	In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection.	Iron	52-56	transferrin	Mus musculus	57-68
164233-3	1975	The reduction of adrenal ferredoxin (adrenodoxin) at low temperatures was investigated in order to separate local modifications of the active centre of the protein on its reduction, from the conformational transition which seems to accompany the change of the redox state of the irons; The ESR spectra of the states of the protein, where the reduced active centre is to be found by the "oxidized" conformation of the apoprotein, were obtained.	Iron	279-284	ferredoxin 1	Homo sapiens	17-35
4347785-0	1972	Spin-spin interaction between molybdenum and one of the iron-sulphur systems of xanthine oxidase and its relevance to the enzymic mechanism.	Iron	56-60	spindlin 1	Homo sapiens	0-4
4347785-0	1972	Spin-spin interaction between molybdenum and one of the iron-sulphur systems of xanthine oxidase and its relevance to the enzymic mechanism.	Iron	56-60	spindlin 1	Homo sapiens	5-9
4234495-0	1968	[Effect of adenine nucleotides and iron on the heme-synthetase activity "in vitro"].	Iron	35-39	ferrochelatase	Homo sapiens	47-62
6068284-0	1967	Sulfhydryl groups of iron environment in non-heme iron protein (adrenodoxin) as an oxidation-reduction component of steroid 11-beta-hydroxylase from adrenal mitochondria.	Iron	21-25	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	116-143
16654469-0	1952	THE UPTAKE OF PHOSPHORUS BY BEAN PLANTS WITH PARTICULAR REFERENCE TO THE EFFECTS OF IRON.	Iron	84-88	brain expressed associated with NEDD4 1	Homo sapiens	28-32
33319934-7	2021	All of these findings suggested that LTCC and TTCC play crucial roles in the Fe2+ uptake, whereas LCN-2 and LCN-2R were essential for Fe3+ uptake into the cardiomyocytes under iron overload conditions.	Iron	176-180	lipocalin 2	Homo sapiens	98-103
33872987-2	2021	The ABCB8 is involved in the maturation of Fe-S and protects the heart from oxidative stress.	Iron	43-47	ATP binding cassette subfamily B member 8	Homo sapiens	4-9
34029365-4	2021	show that like central carbon metabolism, iron metabolism is also closely implicated in autophagy-mediated life extension via the TORC2 activator Ypk1p and the iron regulator Aft1p.	Iron	42-46	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	175-180
34029365-4	2021	show that like central carbon metabolism, iron metabolism is also closely implicated in autophagy-mediated life extension via the TORC2 activator Ypk1p and the iron regulator Aft1p.	Iron	160-164	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	175-180
34031459-0	2021	A two-hybrid system reveals previously uncharacterized protein-protein interactions within the Helicobacter pylori NIF iron-sulfur maturation system.	Iron	119-123	S100 calcium binding protein A9	Homo sapiens	115-118
34002695-0	2021	The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	4-12
33956446-2	2021	In the presence of Mo ions, we find that varying the oxidation state of the iron precursor from Fe(II) to Fe(III) causes a progressive loss of atomic long-range order with the stabilization of 2-4 nm particles for the sample prepared with Fe(III).	Iron	76-80	general transcription factor IIE subunit 1	Homo sapiens	106-108
34000515-0	2021	SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Beta and IL-18.	Iron	37-41	sirtuin 1	Homo sapiens	0-5
34000515-0	2021	SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Beta and IL-18.	Iron	37-41	interleukin 18	Homo sapiens	116-121
34000515-12	2021	CONCLUSION: Activation of SIRT1 can inhibit the ferroptosis and IL-1beta and IL-18 levels of foam cells in excess iron by autophagy, providing a novel therapeutic target for AS.	Iron	114-118	sirtuin 1	Homo sapiens	26-31
34040625-0	2021	Investigation of Genotype by Environment Interactions for Seed Zinc and Iron Concentration and Iron Bioavailability in Common Bean.	Iron	95-99	brain expressed associated with NEDD4 1	Homo sapiens	126-130
34040625-2	2021	Common bean is a widely consumed staple crop around the world and is an excellent source of protein, fiber, and minerals including iron and zinc.	Iron	131-135	brain expressed associated with NEDD4 1	Homo sapiens	7-11
34040625-3	2021	The development of nutrient-dense common bean varieties that deliver more bioavailable iron and zinc with a high level of trait stability requires a measurement of the contributions from genotype, environment, and genotype by environment interactions.	Iron	87-91	brain expressed associated with NEDD4 1	Homo sapiens	41-45
33675347-4	2021	OBJECTIVES: We aimed to determine the effect of antenatal oral iron supplementation on FGF23 concentration and maternal and infant markers of bone-mineral regulation.	Iron	63-67	fibroblast growth factor 23	Homo sapiens	87-92
33675347-9	2021	Antenatal iron supplementation reduced geometric mean total-FGF23 concentrations in mothers and neonates by 62.6% (95% CI: 53.0%, 70.3%) and 15.2% (95% CI: -0.3%, 28.4%, P = 0.06), respectively.	Iron	10-14	fibroblast growth factor 23	Homo sapiens	60-65
33675347-11	2021	CONCLUSIONS: Analysis of this randomized trial confirms that iron supplementation can reverse elevated FGF23 production caused by iron deficiency in iron-deficient mothers and their neonates.	Iron	61-65	fibroblast growth factor 23	Homo sapiens	103-108
33675347-12	2021	Further investigations are warranted to assess to what extent iron supplementation can prevent FGF23-mediated hypophosphatemic rickets or osteomalacia.	Iron	62-66	fibroblast growth factor 23	Homo sapiens	95-100
33956021-0	2021	A highly efficient Fe-Ni-S/NF hybrid electrode for promoting oxygen evolution performance.	Iron	19-21	neurofascin	Homo sapiens	27-29
33945675-0	2021	Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature.	Iron	22-26	lipocalin 2	Homo sapiens	0-11
33945675-4	2021	LCN2 is a neutrophil gelatinase-associated protein that influences diverse cellular processes, including the immune system, iron homeostasis, lipid metabolism, and inflammatory responses.	Iron	124-128	lipocalin 2	Homo sapiens	0-4
33885298-0	2021	Experimental Evidence of syn H-N-Fe-H Configurational Requirement for Iron-Based Bifunctional Hydrogenation Catalysts.	Iron	33-35	synemin	Homo sapiens	25-28
33885298-0	2021	Experimental Evidence of syn H-N-Fe-H Configurational Requirement for Iron-Based Bifunctional Hydrogenation Catalysts.	Iron	70-74	synemin	Homo sapiens	25-28
33323945-8	2021	We found that TfR2 deletion can provide neuroprotection against dopaminergic degeneration, and against PD- and aging-related iron overload.	Iron	125-129	transferrin receptor 2	Mus musculus	14-18
33323945-10	2021	Our data indicate that the TfR2 iron import pathway represents an amenable strategy to hamper PD progression.	Iron	32-36	transferrin receptor 2	Mus musculus	27-31
32959226-5	2021	Lipocalin 2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	Iron	95-99	lipocalin 2	Homo sapiens	0-11
32959226-5	2021	Lipocalin 2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	Iron	95-99	lipocalin 2	Homo sapiens	13-17
33987030-1	2021	Background: Hepcidin controls iron homeostasis by inducing the degradation of the iron efflux protein, ferroportin (FPN1), and subsequently reducing serum iron levels.	Iron	30-34	hepcidin antimicrobial peptide	Mus musculus	12-20
33987030-1	2021	Background: Hepcidin controls iron homeostasis by inducing the degradation of the iron efflux protein, ferroportin (FPN1), and subsequently reducing serum iron levels.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	12-20
33987030-1	2021	Background: Hepcidin controls iron homeostasis by inducing the degradation of the iron efflux protein, ferroportin (FPN1), and subsequently reducing serum iron levels.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	12-20
33987030-2	2021	Hepcidin expression is influenced by multiple factors, including iron stores, ineffective erythropoiesis, and inflammation.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	0-8
33987030-12	2021	Despite the altered expression of the aforementioned hepcidin regulators, the stimulatory effect of LPS on hepcidin mRNA expression was blunt in iron-treated Hbbth3 /+ mice.	Iron	145-149	hepcidin antimicrobial peptide	Mus musculus	107-115
33987030-14	2021	Conclusion: Our study suggests that a hypoferremic response to LPS-induced acute inflammation is maintained in thalassemic mice with parenteral iron loading in a hepcidin-independent manner.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	162-170
33922324-3	2021	In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice.	Iron	10-14	transferrin	Mus musculus	98-109
33922324-3	2021	In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice.	Iron	47-51	transferrin	Mus musculus	98-109
33882101-0	2021	Iron enhances the binding rates and translational efficiency of iron responsive elements (IREs) mRNA with initiation factor eIF4F.	Iron	0-4	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	124-129
33882101-0	2021	Iron enhances the binding rates and translational efficiency of iron responsive elements (IREs) mRNA with initiation factor eIF4F.	Iron	64-68	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	124-129
33882101-4	2021	Addition of iron enhanced the association rates and lowered the dissociation rates for the eIF4F binding to both IRE RNAs, with having higher preferential binding to the FRT IRE RNA.	Iron	12-16	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	91-96
33882101-7	2021	This suggests that iron promotes translation by enhancing the binding rates of the eIF4F IRE RNA complex.	Iron	19-23	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	83-88
33954177-13	2021	This may be caused by increased iron absorption due to massive erythropoietic activity, characterized by an increase in GDF15 levels, which does not cause hepcidin suppression.	Iron	32-36	growth differentiation factor 15	Homo sapiens	120-125
33843441-6	2021	We further demonstrated that NCOA4 (nuclear receptor coactivator 4)-mediated ferritinophagy (autophagic degradation of the major intracellular iron storage protein ferritin) was required for the ferroptosis induced by ZnONPs, by showing that NCOA4 knockdown can reduce the intracellular iron level and lipid peroxidation, and subsequently alleviate ZnONPs-induced cell death.	Iron	143-147	nuclear receptor coactivator 4	Homo sapiens	29-34
33843441-6	2021	We further demonstrated that NCOA4 (nuclear receptor coactivator 4)-mediated ferritinophagy (autophagic degradation of the major intracellular iron storage protein ferritin) was required for the ferroptosis induced by ZnONPs, by showing that NCOA4 knockdown can reduce the intracellular iron level and lipid peroxidation, and subsequently alleviate ZnONPs-induced cell death.	Iron	143-147	nuclear receptor coactivator 4	Homo sapiens	36-66
33843441-6	2021	We further demonstrated that NCOA4 (nuclear receptor coactivator 4)-mediated ferritinophagy (autophagic degradation of the major intracellular iron storage protein ferritin) was required for the ferroptosis induced by ZnONPs, by showing that NCOA4 knockdown can reduce the intracellular iron level and lipid peroxidation, and subsequently alleviate ZnONPs-induced cell death.	Iron	287-291	nuclear receptor coactivator 4	Homo sapiens	29-34
33843441-6	2021	We further demonstrated that NCOA4 (nuclear receptor coactivator 4)-mediated ferritinophagy (autophagic degradation of the major intracellular iron storage protein ferritin) was required for the ferroptosis induced by ZnONPs, by showing that NCOA4 knockdown can reduce the intracellular iron level and lipid peroxidation, and subsequently alleviate ZnONPs-induced cell death.	Iron	287-291	nuclear receptor coactivator 4	Homo sapiens	36-66
33749257-1	2021	Iron coordination polymer, Fe(ox)(H2O)2 (H2ox = oxalic acid) nanorods were grown on a nickel foam (NF) collector via a one-step electrodeposition method, which can be directly used as a freestanding and binder-free electrode for efficient oxygen evolution reaction (OER) electrocatalysis.	Iron	0-4	neurofascin	Homo sapiens	99-101
33916579-1	2021	Mitochondrial production of 2-hydroxyglutarate (2HG) can be catalyzed by wild-type isocitrate dehydrogenase 2 (IDH2) and alcohol dehydrogenase, iron-containing 1 (ADHFE1).	Iron	144-148	alcohol dehydrogenase iron containing 1	Homo sapiens	163-169
33549702-0	2021	The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1.	Iron	35-39	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	106-110
33549702-3	2021	In budding yeast, the high affinity iron regulon is under the control of the transcription factor Aft1.	Iron	36-40	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	98-102
33549702-4	2021	We present evidence demonstrating that the MAPK Slt2 of the cell wall integrity pathway (CWI), phosphorylates and negatively regulates Aft1 activity upon the iron depletion signal, both in fermentative or respiratory conditions.	Iron	158-162	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	135-139
33360887-2	2021	Herein, a simple room-temperature sulfuration method was developed for in situ synthesis of walnut kernel-like iron-cobalt-nickel sulfide nanosheets on nickel foam (FeCoNiSx/NF).	Iron	111-115	neurofascin	Homo sapiens	174-176
33734982-0	2021	Striking While the Iron Is Hot: Using the Updated PHM Competencies in Time-Variable Training.	Iron	19-23	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	50-53
33592798-6	2021	As a result, an impressive sensing behaviour is achieved at the proposed Ni/Fe(SDS)-LDHs modified electrode with a sensitivity of 15.79 muA muM-1 cm-2.	Iron	76-78	PWWP domain containing 3A, DNA repair factor	Homo sapiens	140-145
33842315-11	2021	A functional role of STEAP4 intervention was established in HER2 overexpressing BC by pharmacological studies, where blockage of the STEAP4 pathway with an iron chelator (Deferiprone) in combination with the HER2 inhibitor Lapatinib led to a significant reduction in cell growth in vitro.	Iron	156-160	STEAP4 metalloreductase	Homo sapiens	21-27
33842315-11	2021	A functional role of STEAP4 intervention was established in HER2 overexpressing BC by pharmacological studies, where blockage of the STEAP4 pathway with an iron chelator (Deferiprone) in combination with the HER2 inhibitor Lapatinib led to a significant reduction in cell growth in vitro.	Iron	156-160	STEAP4 metalloreductase	Homo sapiens	133-139
33937615-0	2021	Localization and Kinetics of the Transferrin-Dependent Iron Transport Machinery in the Mouse Placenta.	Iron	55-59	transferrin	Mus musculus	33-44
33937615-5	2021	Fluorescent imaging of maternally injected transferrin iron in the placentas collected at 6 time points postinjection (n = 1-3 animals/time point) showed that transferrin iron was taken up and metabolized within syncytiotrophoblast I within 48 h after injection.	Iron	55-59	transferrin	Mus musculus	43-54
33131943-5	2021	The experimental results indicate that MOR-2-QAS becomes rapidly attached and efficiently removes Pt(CN)42-, Pd(CN)42-, Co(CN)63-, and Fe(CN)63-.	Iron	135-137	FRY like transcription coactivator	Homo sapiens	39-44
34026460-2	2021	A great majority of DGUOK mutant MDS patients develop iron overload progressing to severe liver failure.	Iron	54-58	deoxyguanosine kinase	Homo sapiens	20-25
34026460-6	2021	DGUOK mutant iHep and iHep-Orgs, but not control and corrected one, are more sensitive to iron overload-induced ferroptosis, which can be rescued by N-Acetylcysteine (NAC).	Iron	90-94	deoxyguanosine kinase	Homo sapiens	0-5
34026460-7	2021	Mechanically, this ferroptosis is a process mediated by nuclear receptor co-activator 4 (NCOA4)-dependent degradation of ferritin in lysosome and cellular labile iron release.	Iron	162-166	nuclear receptor coactivator 4	Homo sapiens	56-87
34026460-7	2021	Mechanically, this ferroptosis is a process mediated by nuclear receptor co-activator 4 (NCOA4)-dependent degradation of ferritin in lysosome and cellular labile iron release.	Iron	162-166	nuclear receptor coactivator 4	Homo sapiens	89-94
32468223-5	2021	Moreover, iron overload increased serum D-lactate (D-LA) levels and decreased tight junction proteins (claudin-1, occludin, and ZO-1), MUC-2, and TFF3.	Iron	10-14	claudin 1	Mus musculus	103-112
32468223-5	2021	Moreover, iron overload increased serum D-lactate (D-LA) levels and decreased tight junction proteins (claudin-1, occludin, and ZO-1), MUC-2, and TFF3.	Iron	10-14	mucin 2	Mus musculus	135-140
33370714-0	2021	The protective effect of the cardiac thioredoxin system on the heart in the case of iron overload in mice.	Iron	84-88	thioredoxin 1	Mus musculus	37-48
33370714-6	2021	This study"s goal was to understand how iron overload affects the gene and protein levels of the thioredoxin system in the mouse heart.	Iron	40-44	thioredoxin 1	Mus musculus	97-108
33370714-14	2021	The expression of hepcidin (Hamp) and ferroportin (Fpn) increased with iron overload.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	18-26
33370714-14	2021	The expression of hepcidin (Hamp) and ferroportin (Fpn) increased with iron overload.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	28-32
33370714-19	2021	CONCLUSION: In the case of iron overload, the cardiac thioredoxin system is affected by the protein level rather than the gene level.	Iron	27-31	thioredoxin 1	Mus musculus	54-65
33394258-1	2021	C19orf12 gene biallelic mutations lead mainly to neurodegeneration with brain iron accumulation-4.	Iron	78-82	chromosome 19 open reading frame 12	Homo sapiens	0-8
32974854-5	2021	The mechanism of ferritin-mediated iron recycling is far from clarified, though nuclear receptor co-activator 4 (NCOA4) was recently identified as a cargo receptor for ferritin-based lysosomal degradation.	Iron	35-39	nuclear receptor coactivator 4	Homo sapiens	80-111
32974854-5	2021	The mechanism of ferritin-mediated iron recycling is far from clarified, though nuclear receptor co-activator 4 (NCOA4) was recently identified as a cargo receptor for ferritin-based lysosomal degradation.	Iron	35-39	nuclear receptor coactivator 4	Homo sapiens	113-118
33507238-4	2021	The signal of iron deprivation requires Tor2/Ypk1 activity and the inactivation of Tor1 leading to Atg13 dephosphorylation, thus triggering the autophagy process.	Iron	14-18	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	83-87
33507238-5	2021	Iron replenishment in its turn, reduces autophagy flux through the AMPK Snf1 and the subsequent activity of the iron responsive transcription factor, Aft1.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	150-154
33507238-5	2021	Iron replenishment in its turn, reduces autophagy flux through the AMPK Snf1 and the subsequent activity of the iron responsive transcription factor, Aft1.	Iron	112-116	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	150-154
33265044-4	2021	The results showed that the tap water quality deteriorated after overnight stagnation, with up to a 2.7-fold increase in the total iron concentrations.	Iron	131-135	nuclear RNA export factor 1	Homo sapiens	28-31
33598426-1	2020	CISD2, a NEET protein that coordinates 2Fe-2S clusters through its CDGSH domain, is critical for normal development and iron homeostasis.	Iron	120-124	CDGSH iron sulfur domain 2	Homo sapiens	0-5
33598426-2	2020	CISD2 plays an important role in Fe-S cluster transfer and promotes cancer proliferation.	Iron	33-35	CDGSH iron sulfur domain 2	Homo sapiens	0-5
33598426-10	2020	Moreover, CISD2 inhibition activated the iron starvation response, thus, accelerating iron accumulation in A549 cells.	Iron	41-45	CDGSH iron sulfur domain 2	Homo sapiens	10-15
33598426-10	2020	Moreover, CISD2 inhibition activated the iron starvation response, thus, accelerating iron accumulation in A549 cells.	Iron	86-90	CDGSH iron sulfur domain 2	Homo sapiens	10-15
33598426-11	2020	Pretreatment with DFO, the iron chelator, blocked mitochondrial dysfunction in CISD2-knockdown cells.	Iron	27-31	CDGSH iron sulfur domain 2	Homo sapiens	79-84
33336851-14	2021	Iron accumulation led to the high expression of XIST and promoted osteoblast apoptosis through miR-758-3p/caspase 3.	Iron	0-4	inactive X specific transcripts	Mus musculus	48-52
33336851-14	2021	Iron accumulation led to the high expression of XIST and promoted osteoblast apoptosis through miR-758-3p/caspase 3.	Iron	0-4	caspase 3	Mus musculus	106-115
33336851-16	2021	CONCLUSION: Iron accumulation regulated osteoblast apoptosis through XIST/miR-758-3p/caspase 3 axis, which might provide alternative targets for the treatment of osteoporosis.	Iron	12-16	inactive X specific transcripts	Mus musculus	69-73
33336851-16	2021	CONCLUSION: Iron accumulation regulated osteoblast apoptosis through XIST/miR-758-3p/caspase 3 axis, which might provide alternative targets for the treatment of osteoporosis.	Iron	12-16	caspase 3	Mus musculus	85-94
33049075-4	2021	New evidence points to involvement of the hypoxia-inducible factor (HIF)/erythropoietin (EPO)/iron pathway as important in FGF23 physiology.	Iron	94-98	fibroblast growth factor 23	Homo sapiens	123-128
33477809-6	2021	In CISD2, the [2Fe-2S] cluster, through coordinates of 3-cysteine-1-histidine on the CDGSH domain, acts as a homeostasis regulator under environmental stress through the transfer of electrons or iron-sulfur clusters.	Iron	140-144	CDGSH iron sulfur domain 2	Homo sapiens	3-8
33462793-0	2021	The Effect of Iron Supplementation on FGF23 in Chronic Kidney Disease Patients: a Systematic Review and Time-Response Meta-Analysis.	Iron	14-18	fibroblast growth factor 23	Homo sapiens	38-43
33462793-2	2021	We evaluated the efficacy of different iron treatments on FGF23 levels in dialysis-dependent and non-dialysis-dependent CKD patients with IDA.	Iron	39-43	fibroblast growth factor 23	Homo sapiens	58-63
33462793-4	2021	We investigated the efficacy of iron treatment on the levels of FGF23 and C-terminal FGF23 (cFGF23) in CKD patients.	Iron	32-36	fibroblast growth factor 23	Homo sapiens	64-69
33462793-4	2021	We investigated the efficacy of iron treatment on the levels of FGF23 and C-terminal FGF23 (cFGF23) in CKD patients.	Iron	32-36	fibroblast growth factor 23	Homo sapiens	85-90
33462793-7	2021	Overall, iron treatment showed a significant reduction in FGF23 levels compared to control group (WMD: - 60.56 pg/ml, 95% CI: - 92.17, - 28.95).	Iron	9-13	fibroblast growth factor 23	Homo sapiens	58-63
33462793-8	2021	Compared to placebo, subgroup analysis showed that oral iron therapy (WMD: - 6.98 pg/ml, 95% CI: - 10.66, - 3.31) was more effective than intravenous (IV) iron therapy (WMD: 4.90 pg/ml, 95% CI: - 12.03, 21.83) on FGF23 levels.	Iron	56-60	fibroblast growth factor 23	Homo sapiens	213-218
33480755-1	2021	We demonstrate ground state tunability for a hybrid artificial spin ice composed of Fe nanomagnets which are subject to site-specific exchange-bias fields, applied in integer multiples of the lattice along one sublattice of the classic square artificial spin ice.	Iron	84-86	spindlin 1	Homo sapiens	63-67
33402128-3	2021	NCOA4 depletion can eliminate iron accumulation and thus weaken ferroptosis.	Iron	30-34	nuclear receptor coactivator 4	Homo sapiens	0-5
33091395-0	2021	Novel Mutations in ATP13A2 Associated with Mixed Neurological Presentations and Iron Toxicity due to Nonsense-Mediated Decay.	Iron	80-84	ATPase cation transporting 13A2	Homo sapiens	19-26
33091395-11	2021	Iron accumulation due to the absence of ATP13A2 protein in the patient"s fibroblasts and hypointense areas on T2-weighted images may expand the spectrum of KRS to consider it as neurodegeneration with brain iron accumulation disorders.	Iron	0-4	ATPase cation transporting 13A2	Homo sapiens	40-47
33065090-5	2021	Experimental TIM2 downregulation in the mouse retina promoted, probably due to a compensatory mechanism, Scara5 overexpression that increased retinal ferritin uptake and induced iron overload.	Iron	178-182	scavenger receptor class A, member 5	Mus musculus	105-111
32079697-0	2021	Macrophage-HFE controls iron metabolism and immune responses in aged mice.	Iron	24-28	homeostatic iron regulator	Mus musculus	11-14
33126055-2	2021	HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic radical reaction.	Iron	121-123	phosphatidylethanolamine binding protein 1	Homo sapiens	96-101
32829157-0	2020	Interaction of ferritin iron responsive element (IRE) mRNA with translation initiation factor eIF4F.	Iron	24-28	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	94-99
32829157-1	2020	The interaction of ferritin iron responsive element (IRE) mRNA with eIF4F was examined by fluorescence and circular dichroism spectroscopy.	Iron	28-32	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	68-73
32829157-6	2020	The addition of iron increased the enthalpic, while decreasing the entropic contribution towards the eIF4F IRE RNA complex, resulting in favorable free energy (DeltaG = -49.8 +- 2.8 kJ/mol).	Iron	16-20	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	101-106
32829157-11	2020	The conformational change in the eIF4F structure, caused by the IRE RNA binding, provides a more stable platform for effective IRE translation in iron homeostasis.	Iron	146-150	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	33-38
33291459-2	2020	Complexation of the 8,8"-bis(methylsulfanyl) derivatives of cobalt and iron bis(dicarbollides) [8,8"-(MeS)2-3,3"-M(1,2-C2B9H10)2]- (M = Co, Fe) with copper, silver, palladium and rhodium leads to the formation of the corresponding chelate complexes, which is accompanied by a transition from the transoid to the cisoid conformation of the bis(dicarbollide) complex.	Iron	140-142	MKS transition zone complex subunit 1	Homo sapiens	102-105
33270853-0	2020	Iron on the move: mobilizing liver iron via NCOA4.	Iron	0-4	nuclear receptor coactivator 4	Homo sapiens	44-49
33270853-0	2020	Iron on the move: mobilizing liver iron via NCOA4.	Iron	35-39	nuclear receptor coactivator 4	Homo sapiens	44-49
33242392-4	2020	We demonstrate that fSHAPE patterns predict binding sites of known RBPs, such as iron response elements in both known loci and previously unknown loci in CDC34, SLC2A4RG, COASY, and H19.	Iron	81-85	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	154-159
32009585-2	2020	The hemoglobin content of reticulocytes (CHr) is a sensitive indicator of iron used for hematopoiesis.	Iron	74-78	chromate resistance; sulfate transport	Homo sapiens	41-44
33148716-0	2020	ESAT-6 Protein of Mycobacterium tuberculosis Increases Holotransferrin-Mediated Iron Uptake in Macrophages by Downregulating Surface Hemochromatosis Protein HFE.	Iron	80-84	homeostatic iron regulator	Mus musculus	157-160
33148716-7	2020	In the current study, we report that interaction of the ESAT-6 protein with beta2M causes downregulation of surface HFE, a protein regulating iron homeostasis via interacting with transferrin receptor 1 (TFR1).	Iron	142-146	homeostatic iron regulator	Mus musculus	116-119
33148716-8	2020	We found that ESAT-6:beta2M interaction leads to sequestration of HFE in endoplasmic reticulum, causing poorer surface expression of HFE and HFE:TFR1 complex (nonfunctional TFR1) in peritoneal macrophages from C57BL/6 mice, resulting in increased holotransferrin-mediated iron uptake in these macrophages.	Iron	272-276	homeostatic iron regulator	Mus musculus	66-69
31295987-0	2020	BDNF pathway regulates TrkB expression in hippocampus of iron-deficient young rats.	Iron	57-61	brain-derived neurotrophic factor	Rattus norvegicus	0-4
32920472-0	2020	Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	81-89
32920472-2	2020	In peripheral cells, the expression of hepcidin, a master regulator of iron homeostasis, is regulated by estrogen.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	39-47
32920472-3	2020	This study aimed to determine whether hepcidin was involved in iron deposition in the brain and brain endothelial cells of estrogen-deficient aged female mice.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	38-46
33324701-0	2020	orf6 and orf10 in Prophage phiv142-3 Enhance the Iron-Acquisition Ability and Resistance of Avian Pathogenic Escherichia coli Strain DE142 to Serum.	Iron	49-53	hypothetical protein	Escherichia coli	0-4
33324701-11	2020	Together, these results suggested that orf6 affects growth by contributing to the uptake ability of iron, while orf10 increases resistance to serum by upregulating K1 capsule-related genes.	Iron	100-104	hypothetical protein	Escherichia coli	39-43
32678895-6	2020	Taking advantage of the physiological iron-dependent post-transcriptional regulation of ALAS2, we evaluated whether iron chelation with deferiprone could decrease ALAS2 expression and subsequent porphyrin production in vitro and in vivo in a CEP murine model.	Iron	38-42	aminolevulinic acid synthase 2, erythroid	Mus musculus	88-93
32678895-6	2020	Taking advantage of the physiological iron-dependent post-transcriptional regulation of ALAS2, we evaluated whether iron chelation with deferiprone could decrease ALAS2 expression and subsequent porphyrin production in vitro and in vivo in a CEP murine model.	Iron	116-120	aminolevulinic acid synthase 2, erythroid	Mus musculus	163-168
33025000-0	2020	Iron Biofortification: Who Gives a Bean?	Iron	0-4	brain expressed associated with NEDD4 1	Homo sapiens	35-39
32930569-0	2020	6,11-Dioxobenzo[f]pyrido[1,2-a]indoles kill Mycobacterium tuberculosis by targeting iron-sulfur protein Rv0338c (IspQ) a putative redox sensor.	Iron	84-88	iron-sulfur-binding reductase	Mycobacterium tuberculosis H37Rv	104-111
32930569-5	2020	Four different mutations, all affecting highly conserved residues, were uncovered in the essential gene rv0338c (ispQ) that encodes a membrane-bound protein, named IspQ, with 2Fe-2S and 4Fe-4S centres and putative iron-sulfur-binding reductase activity.	Iron	214-218	iron-sulfur-binding reductase	Mycobacterium tuberculosis H37Rv	104-111
33258645-1	2020	We report the results of a new search for long-range spin-dependent interactions using a Rb-^{21}Ne atomic comagnetometer and a rotatable electron spin source based on a SmCo_{5} magnet with an iron flux return.	Iron	194-198	spindlin 1	Homo sapiens	53-57
33298848-7	2020	These lines of evidence provide a new mechanistic insight into the mechanism of loss of PDLFs during periodontitis development, showing that periodontitis-level butyrate disrupted iron homeostasis by activation of NCOA4-mediated ferritinophagy, leading to ferroptosis in PDLFs.	Iron	180-184	nuclear receptor coactivator 4	Homo sapiens	214-219
33171063-2	2020	Bacteria synthesize siderophores to sequester host iron, whereas lipocalin 2 (Lcn2) is the host defense protein that prevent this iron thievery.	Iron	130-134	lipocalin 2	Homo sapiens	65-76
33171063-2	2020	Bacteria synthesize siderophores to sequester host iron, whereas lipocalin 2 (Lcn2) is the host defense protein that prevent this iron thievery.	Iron	130-134	lipocalin 2	Homo sapiens	78-82
33171063-6	2020	Using three human IEC cell-lines with differential basal levels of Lcn2 (i.e. HT29 < DLD-1 < Caco-2/BBe), we demonstrated that iron-free Ent could induce a dose-dependent secretion of the pro-inflammatory chemokine, interleukin 8 (IL-8), in HT29 and DLD-1 IECs, but not in Caco-2/BBe.	Iron	127-131	lipocalin 2	Homo sapiens	67-71
32966382-3	2020	Herein, GGT-targeting nanopolyplexes (gamma-pGluA-CSO@Fe3+, PCFN) consisting of cationic chitosan and GGT-targeting gamma-pGluA blended with iron ion were constructed to load reactive oxygen species-induced menadione (MA) and doxorubicin, which were utilized to investigate the mechanism of GGT up-regulation.	Iron	141-145	inactive glutathione hydrolase 2	Homo sapiens	8-11
32966382-3	2020	Herein, GGT-targeting nanopolyplexes (gamma-pGluA-CSO@Fe3+, PCFN) consisting of cationic chitosan and GGT-targeting gamma-pGluA blended with iron ion were constructed to load reactive oxygen species-induced menadione (MA) and doxorubicin, which were utilized to investigate the mechanism of GGT up-regulation.	Iron	141-145	inactive glutathione hydrolase 2	Homo sapiens	102-105
32966382-3	2020	Herein, GGT-targeting nanopolyplexes (gamma-pGluA-CSO@Fe3+, PCFN) consisting of cationic chitosan and GGT-targeting gamma-pGluA blended with iron ion were constructed to load reactive oxygen species-induced menadione (MA) and doxorubicin, which were utilized to investigate the mechanism of GGT up-regulation.	Iron	141-145	inactive glutathione hydrolase 2	Homo sapiens	102-105
33172243-5	2020	INTERPRETATION: Mutations in FTL are known to interfere with the balance between iron levels and ferritin production.	Iron	81-85	ferritin light chain	Homo sapiens	29-32
33151470-7	2021	A positive interrelation between quantitative trichogram parameters in the occipital region and iron metabolism in pairs "hair density vs Fe" and "hair diameter vs ferritin" was shown.	Iron	96-100	general transcription factor IIE subunit 1	Homo sapiens	138-140
32767706-2	2020	NCOA4 plays significant roles in systemic iron homeostasis, and its disruption leads to simultaneous anemia and susceptibility to iron overload.	Iron	42-46	nuclear receptor coactivator 4	Homo sapiens	0-5
32767706-2	2020	NCOA4 plays significant roles in systemic iron homeostasis, and its disruption leads to simultaneous anemia and susceptibility to iron overload.	Iron	130-134	nuclear receptor coactivator 4	Homo sapiens	0-5
32767706-4	2020	Disruption of ferritinophagy via NCOA4 knockout leads to only marginal differences in growth under basal and iron-restricted conditions.	Iron	109-113	nuclear receptor coactivator 4	Homo sapiens	33-38
32873629-2	2020	Iron absorption in Arabidopsis root epidermal cells requires the IRT1 transporter that also allows the entry of certain non-iron metals, such as Zn, Mn, and Co.	Iron	0-4	iron-regulated transporter 1	Arabidopsis thaliana	65-69
32873629-2	2020	Iron absorption in Arabidopsis root epidermal cells requires the IRT1 transporter that also allows the entry of certain non-iron metals, such as Zn, Mn, and Co.	Iron	124-128	iron-regulated transporter 1	Arabidopsis thaliana	65-69
32873629-3	2020	Recent work demonstrated that IRT1 endocytosis and degradation are controlled by IRT1 non-iron metal substrates in an ubiquitin-dependent manner.	Iron	90-94	iron-regulated transporter 1	Arabidopsis thaliana	30-34
32873629-5	2020	Interestingly, the AHA2 proton pump and the FRO2 reductase, both of which work in concert with IRT1 in the acidification-reduction-transport strategy of iron uptake, were part of this interactome.	Iron	153-157	H[+]-ATPase 2	Arabidopsis thaliana	19-23
32873629-5	2020	Interestingly, the AHA2 proton pump and the FRO2 reductase, both of which work in concert with IRT1 in the acidification-reduction-transport strategy of iron uptake, were part of this interactome.	Iron	153-157	iron-regulated transporter 1	Arabidopsis thaliana	95-99
32873629-7	2020	We characterized the dynamics of the iron uptake complex and showed that FRO2 and AHA2 ubiquitination is independent of the non-iron metal substrates transported by IRT1.	Iron	37-41	H[+]-ATPase 2	Arabidopsis thaliana	82-86
32873629-9	2020	Indeed, we provide evidence that the phosphorylation of IRT1 in response to high levels of non-iron metals likely triggers dissociation of the complex.	Iron	95-99	iron-regulated transporter 1	Arabidopsis thaliana	56-60
32943465-10	2020	Our results demonstrate that NFS1 and its interactor FH are involved not only in nonhost resistance but also in basal resistance, suggesting a new role of the Fe-S cluster pathway in plant immunity.	Iron	159-163	nitrogen fixation S (NIFS)-like 1	Arabidopsis thaliana	29-33
33298837-0	2020	Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-beta induced brain damage in mice.	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	0-8
33298837-2	2020	Hepcidin expressed by astrocytes has been speculated to regulate iron transport across the blood-brain barrier (BBB) and control the whole brain iron load.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	0-8
33298837-2	2020	Hepcidin expressed by astrocytes has been speculated to regulate iron transport across the blood-brain barrier (BBB) and control the whole brain iron load.	Iron	145-149	hepcidin antimicrobial peptide	Mus musculus	0-8
33298837-3	2020	Whether increasing the expression of astrocyte hepcidin can reduce brain iron level and relieve AD symptoms has yet to be studied.	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	47-55
33298837-7	2020	Our data further demonstrated that astrocyte-overexpressed hepcidin could decrease brain iron level, possibly by acting on ferroportin 1 (FPN1) on the brain microvascular endothelial cells (BMVECs), which in turn reduced Abeta25-35-induced oxidative stress and apoptosis, and ultimately protected cells from damage.	Iron	89-93	hepcidin antimicrobial peptide	Mus musculus	59-67
33298837-8	2020	This study provided in vivo evidences of the important role of astrocyte hepcidin in the regulation of brain iron metabolism and protection against Abeta-induced cortical and hippocampal damages and implied its potential in the treatment of oxidative stress-related brain disorders.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	73-81
33145027-0	2020	Fenofibrate prevents iron induced activation of canonical Wnt/beta-catenin and oxidative stress signaling in the retina.	Iron	21-25	catenin (cadherin associated protein), beta 1	Mus musculus	62-74
33145027-10	2020	We found that in vitro and in vivo iron treatment resulted in the upregulation of Wnt/beta-catenin signaling and its downstream target genes including renin-angiotensin system in the retina.	Iron	35-39	catenin (cadherin associated protein), beta 1	Mus musculus	86-98
33145027-12	2020	The presence of an iron chelator or an antioxidant reversed the iron-mediated upregulation of Wnt/beta-catenin signaling in retinal pigment epithelial (RPE) cells.	Iron	19-23	catenin (cadherin associated protein), beta 1	Mus musculus	98-110
33145027-12	2020	The presence of an iron chelator or an antioxidant reversed the iron-mediated upregulation of Wnt/beta-catenin signaling in retinal pigment epithelial (RPE) cells.	Iron	64-68	catenin (cadherin associated protein), beta 1	Mus musculus	98-110
33145027-13	2020	In addition, treatment of RPE cells with peroxisome proliferator-activated receptor (PPAR) alpha-agonist fenofibrate prevented iron-induced activation of oxidative stress and Wnt/beta-catenin signaling by chelating the iron.	Iron	127-131	catenin (cadherin associated protein), beta 1	Mus musculus	179-191
33052690-5	2020	Meanwhile, in comparison with the FeSO4 group, the intake of NKU556-Fe could suppress the expression of hepcidin derived from the liver and reduce the degradation of FPN1, thereby leading to the increase in the iron absorption of colitis in mice.	Iron	211-215	hepcidin antimicrobial peptide	Mus musculus	104-112
33114262-4	2020	The same hydrolytic tendency could be identified with sal(p-X)ben ligands in the case of iron(III) also by using NEt3 or upon standing in solution, while manganese(III) did not promote such a C-N bond breakage.	Iron	89-93	net3	None	113-117
32227235-7	2020	Moreover, we uncovered liver-resident Kupffer cells (KCs) as central players in cholesterol homeostasis as they were found to acquire and transfer LDL-derived cholesterol to hepatocytes in an Abca1-dependent fashion, which is controlled by iron availability.	Iron	240-244	ATP binding cassette subfamily A member 1	Homo sapiens	192-197
32800558-7	2020	Further study indicated that all the rescue effects of Tsf1 knockdown on sporadic PD could be inhibited by malvolio (Mvl) overexpression, an iron transporter responsible for iron uptake.	Iron	141-145	Malvolio	Drosophila melanogaster	117-120
32800558-7	2020	Further study indicated that all the rescue effects of Tsf1 knockdown on sporadic PD could be inhibited by malvolio (Mvl) overexpression, an iron transporter responsible for iron uptake.	Iron	174-178	Malvolio	Drosophila melanogaster	117-120
33123307-8	2020	ROS induced by iron overload promote necroptosis via a positive feedback mechanism, as on the one hand N-acetylcysteine attenuates the upregulation of RIPK1 and RIPK3 and phosphorylation of RIPK1, RIPK3, and MLKL and on the other hand Nec-1, siRIPK1, or siRIPK3 reduced ROS generation.	Iron	15-19	receptor interacting serine/threonine kinase 3	Homo sapiens	161-166
33123307-8	2020	ROS induced by iron overload promote necroptosis via a positive feedback mechanism, as on the one hand N-acetylcysteine attenuates the upregulation of RIPK1 and RIPK3 and phosphorylation of RIPK1, RIPK3, and MLKL and on the other hand Nec-1, siRIPK1, or siRIPK3 reduced ROS generation.	Iron	15-19	receptor interacting serine/threonine kinase 3	Homo sapiens	197-202
33123307-9	2020	In summary, iron overload induced necroptosis of osteoblastic cells in vitro, which is mediated, at least in part, through the RIPK1/RIPK3/MLKL pathway.	Iron	12-16	receptor interacting serine/threonine kinase 3	Homo sapiens	133-138
33054105-1	2021	Mutations in HFE cause hereditary hemochromatosis type I hallmarked by increased iron absorption, iron accumulation in hepatocytes and iron deficiency in myeloid cells.	Iron	81-85	homeostatic iron regulator	Mus musculus	13-16
33054105-1	2021	Mutations in HFE cause hereditary hemochromatosis type I hallmarked by increased iron absorption, iron accumulation in hepatocytes and iron deficiency in myeloid cells.	Iron	98-102	homeostatic iron regulator	Mus musculus	13-16
33054105-6	2021	By contrast, mice with hepatocyte-specific deletion of Hfe succumbed earlier to Salmonella infection because of unrestricted extracellular bacterial replication associated with high iron availability in the serum and impaired expression of essential host defense molecules such as interleukin-6, interferon-gamma and nitric oxide synthase-2.	Iron	182-186	homeostatic iron regulator	Mus musculus	55-58
33054105-7	2021	Wild-type mice subjected to dietary iron overload phenocopied hepatocyte-specific Hfe deficiency suggesting that increased iron availability in the serum is deleterious in Salmonella infection and underlies impaired host immune responses.	Iron	36-40	homeostatic iron regulator	Mus musculus	82-85
33054105-7	2021	Wild-type mice subjected to dietary iron overload phenocopied hepatocyte-specific Hfe deficiency suggesting that increased iron availability in the serum is deleterious in Salmonella infection and underlies impaired host immune responses.	Iron	123-127	homeostatic iron regulator	Mus musculus	82-85
33054105-8	2021	Moreover, the macrophage-specific effect is dominant over hepatocyte-specific Hfe-depletion, as Hfe knock-out mice have increased survival despite the higher parenchymal iron load associated with systemic loss of Hfe.	Iron	170-174	homeostatic iron regulator	Mus musculus	96-99
33054105-8	2021	Moreover, the macrophage-specific effect is dominant over hepatocyte-specific Hfe-depletion, as Hfe knock-out mice have increased survival despite the higher parenchymal iron load associated with systemic loss of Hfe.	Iron	170-174	homeostatic iron regulator	Mus musculus	96-99
33054105-9	2021	We conclude that cell-specific expression of Hfe in hepatocytes and macrophages differentially affects the course of infections with specific pathogens by determining bacterial iron access and the efficacy of anti-microbial immune effector pathways.	Iron	177-181	homeostatic iron regulator	Mus musculus	45-48
32343570-1	2020	The atomistic-level understanding of iron speciation and the probable oxidative behavior of iron (Fe(aq)2+ Fe(surf)3+) in clay minerals is fundamental for environmental geochemistry of redox reactions.	Iron	92-96	ribosomal protein L7a	Homo sapiens	107-116
32692954-0	2020	Further insights into the role of bHLH121 in the regulation of iron homeostasis in Arabidopsis thaliana.	Iron	63-67	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	34-41
32692954-6	2020	Herein it is shown that bHLH121 is necessary for the expression of the main markers of the plant responses to Fe excess, the ferritin genes (i.e. FER1, FER3, and FER4).	Iron	110-112	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	24-31
32971361-0	2020	Glutathionylated and Fe-S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain.	Iron	21-25	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	45-51
32971361-0	2020	Glutathionylated and Fe-S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain.	Iron	21-25	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	53-59
31872339-6	2020	In animal experiments, we found that FeTmPyP, a representative ONOO- decomposition catalyst (PDC), significantly reduced the expression of HMGB1 and its receptor TLR2, and inhibited MMP-9 activation, preserved collagen IV and tight junction claudin-5 in ischemic rat brains with delayed t-PA treatment.	Iron	37-44	high mobility group box 1	Rattus norvegicus	139-144
31872339-6	2020	In animal experiments, we found that FeTmPyP, a representative ONOO- decomposition catalyst (PDC), significantly reduced the expression of HMGB1 and its receptor TLR2, and inhibited MMP-9 activation, preserved collagen IV and tight junction claudin-5 in ischemic rat brains with delayed t-PA treatment.	Iron	37-44	matrix metallopeptidase 9	Rattus norvegicus	182-187
32978498-1	2020	Mature frataxin is essential for the assembly of iron-sulfur cluster proteins including a number of mitochondrial enzymes.	Iron	49-53	frataxin	Mus musculus	7-15
32977628-7	2020	For example, the extract and all the fractions, at the two highest concentrations of 10 and 50 microg/mL, significantly inhibited the plasma lipid peroxidation induced by H2O2/Fe.	Iron	176-178	thrombopoietin	Mus musculus	102-104
32977628-8	2020	Fractions C and D, at all tested concentrations (1-50 microg/mL) were also found to protect plasma proteins against H2O2/Fe-induced carbonylation.	Iron	121-123	thrombopoietin	Mus musculus	61-63
32975969-0	2020	Neutron Spin Resonance in a Quasi-Two-Dimensional Iron-Based Superconductor.	Iron	50-54	spindlin 1	Homo sapiens	8-12
32975969-2	2020	Here, we report an inelastic neutron scattering study on the low-energy spin excitations in a quasi-two-dimensional iron-based superconductor KCa_{2}Fe_{4}As_{4}F_{2}.	Iron	116-120	spindlin 1	Homo sapiens	72-76
33013818-4	2020	Upon iron deficiency, yeast utilizes two transcription factors, Aft1 and Aft2, to activate the expression of a set of genes known as the iron regulon, which are implicated in iron uptake, recycling and mobilization.	Iron	5-9	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	64-68
33013818-4	2020	Upon iron deficiency, yeast utilizes two transcription factors, Aft1 and Aft2, to activate the expression of a set of genes known as the iron regulon, which are implicated in iron uptake, recycling and mobilization.	Iron	137-141	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	64-68
33013818-5	2020	Moreover, Aft1 and Aft2 activate the expression of Cth2, an mRNA-binding protein that limits the expression of genes encoding for iron-containing proteins or that participate in iron-using processes.	Iron	130-134	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	10-14
33013818-5	2020	Moreover, Aft1 and Aft2 activate the expression of Cth2, an mRNA-binding protein that limits the expression of genes encoding for iron-containing proteins or that participate in iron-using processes.	Iron	178-182	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	10-14
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	8-12	Ccc1p	Saccharomyces cerevisiae S288C	133-137
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	Ccc1p	Saccharomyces cerevisiae S288C	133-137
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	Ccc1p	Saccharomyces cerevisiae S288C	133-137
33013818-8	2020	At high iron levels, the yeast Yap5, Msn2, and Msn4 transcription factors activate the expression of a vacuolar iron importer called Ccc1, which is the most important high-iron protecting factor devoted to detoxify excess cytosolic iron that is stored into the vacuole for its mobilization upon scarcity.	Iron	112-116	Ccc1p	Saccharomyces cerevisiae S288C	133-137
32848065-5	2020	Here, by combining femtosecond Fe Kalpha and Kbeta X-ray emission spectroscopy (XES) with Fe K-edge X-ray absorption near-edge structure (XANES), we demonstrate that the photocycle of ferric Cyt c is entirely due to a cascade among excited spin states of the iron ion, causing the ferric heme to undergo doming, which we identify.	Iron	259-263	cyt c	None	191-196
32721044-0	2020	Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.	Iron	73-77	STEAP4 metalloreductase	Homo sapiens	8-14
32967483-7	2020	In this study, we showed that HRG, in a concentration-dependent manner, efficiently inhibited the production of hydroxyl radical induced by the Fenton"s reaction through chelation of the divalent iron.	Iron	196-200	histidine rich glycoprotein	Homo sapiens	30-33
32863216-7	2020	Importantly, mitochondrial p53 interacted with solute carrier family 25 member 28 (SLC25A28) to form complex and enhanced the activity of SLC25A28, which could lead to the abnormal accumulation of redox-active iron and hyperfunction of electron transfer chain (ETC).	Iron	210-214	solute carrier family 25 member 28	Homo sapiens	47-81
32863216-7	2020	Importantly, mitochondrial p53 interacted with solute carrier family 25 member 28 (SLC25A28) to form complex and enhanced the activity of SLC25A28, which could lead to the abnormal accumulation of redox-active iron and hyperfunction of electron transfer chain (ETC).	Iron	210-214	solute carrier family 25 member 28	Homo sapiens	83-91
32863216-7	2020	Importantly, mitochondrial p53 interacted with solute carrier family 25 member 28 (SLC25A28) to form complex and enhanced the activity of SLC25A28, which could lead to the abnormal accumulation of redox-active iron and hyperfunction of electron transfer chain (ETC).	Iron	210-214	solute carrier family 25 member 28	Homo sapiens	138-146
32812643-0	2020	Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus.	Iron	21-25	integrin subunit alpha M	Homo sapiens	62-66
32812643-3	2020	Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition.	Iron	117-121	integrin subunit alpha M	Homo sapiens	53-57
32812643-4	2020	However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.	Iron	235-239	integrin subunit alpha M	Homo sapiens	209-213
32810223-6	2020	We found that iron-dependent increase of hepatic hepcidin results in neutrophil intracellular iron trapping and consecutive defects in oxidative burst activity.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	49-57
32810223-6	2020	We found that iron-dependent increase of hepatic hepcidin results in neutrophil intracellular iron trapping and consecutive defects in oxidative burst activity.	Iron	94-98	hepcidin antimicrobial peptide	Mus musculus	49-57
32470559-4	2020	Crystal structures of human and mouse SCD1 were reported recently; however, both proteins have two zinc ions instead of two iron ions in the catalytic center, and as a result, the enzymes are inactive.	Iron	124-128	stearoyl-Coenzyme A desaturase 1	Mus musculus	38-42
33194864-8	2020	LEARNING POINTS: The carbohydrate moieties used in parenteral iron preparations are different, and may have a dose-dependent relationship with the development of hypophosphataemia.The mechanism by which hypophosphataemia occurs after parenteral iron replacement is related to increased serum levels of FGF23, which increases renal phosphate wasting.The serum phosphate levels of patients receiving parenteral iron replacement (especially ferric carboxymaltose or iron polymaltose) should be routinely monitored for hypophosphataemia, which is an under-diagnosed complication.	Iron	62-66	fibroblast growth factor 23	Homo sapiens	302-307
32247181-2	2020	Consumption of common bean seeds with the low phytic acid 1 (lpa1) mutation improved iron status in human trials but caused adverse gastrointestinal effects, presumably due to increased stability of lectin phytohemagglutinin L (PHA-L) compared to the wild type (wt).	Iron	85-89	lysophosphatidic acid receptor 1	Homo sapiens	42-59
32247181-2	2020	Consumption of common bean seeds with the low phytic acid 1 (lpa1) mutation improved iron status in human trials but caused adverse gastrointestinal effects, presumably due to increased stability of lectin phytohemagglutinin L (PHA-L) compared to the wild type (wt).	Iron	85-89	lysophosphatidic acid receptor 1	Homo sapiens	61-65
32823844-9	2020	In pre-dialysis CKD patients, the observed association of FGF23 with hemoglobin seems to be restricted to cFGF23 and largely explained by the iron status.	Iron	142-146	fibroblast growth factor 23	Homo sapiens	58-63
32667189-3	2020	In this work we synthesize an efficient hierarchical highly wrinkled NiFeCu phosphide nanosheet on nanodendrite Ni3S2/NiF substrate through partially replacement of Cu instead of Ni and Fe in NiFeP@Ni3S2/NiF by using facile electrodeposition method.	Iron	71-73	S100 calcium binding protein A9	Homo sapiens	118-121
32374849-0	2020	Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis.	Iron	45-49	transferrin	Mus musculus	8-19
32374849-2	2020	Here, we generated hepatocyte-specific Trf knockout mice (Trf-LKO), which are viable and fertile but have impaired erythropoiesis and altered iron metabolism.	Iron	142-146	thyrotropin releasing hormone	Mus musculus	39-42
32374849-2	2020	Here, we generated hepatocyte-specific Trf knockout mice (Trf-LKO), which are viable and fertile but have impaired erythropoiesis and altered iron metabolism.	Iron	142-146	thyrotropin releasing hormone	Mus musculus	58-61
32374849-3	2020	Moreover, feeding Trf-LKO mice a high-iron diet increased their susceptibility to develop ferroptosis-induced liver fibrosis.	Iron	38-42	thyrotropin releasing hormone	Mus musculus	18-21
32374849-4	2020	Importantly, we found that treating Trf-LKO mice with the ferroptosis inhibitor ferrostatin-1 potently rescued liver fibrosis induced by either high dietary iron or carbon tetrachloride (CCl4) injections.	Iron	157-161	thyrotropin releasing hormone	Mus musculus	36-39
32374849-5	2020	In addition, deleting hepatic Slc39a14 expression in Trf-LKO mice significantly reduced hepatic iron accumulation, thereby reducing ferroptosis-mediated liver fibrosis induced by either high dietary iron diet or CCl4 injections.	Iron	96-100	thyrotropin releasing hormone	Mus musculus	53-56
32325343-6	2020	We further investigated the mechanism underlying TCDD-induced hepatocyte apoptosis through apoptosis polymerase chain reaction array, and found that a crucial apoptosis-related gene, cell death-inducing DFF45-like effector b (Cideb), was significantly increased in primary hepatocytes from TCDD-exposed mice, and accompanied by liver iron deposition in hepcidin knockout mice.	Iron	334-338	hepcidin antimicrobial peptide	Mus musculus	353-361
31691189-6	2020	Iron overload stimulated hepcidin synthesis, while IR had an inhibitory effect and even inhibited the stimulatory effects of iron overload.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	25-33
31707638-9	2020	These results indicated that repeated restraint stress induces hepatic iron accumulation, which is closely related to higher expression of hepatic TFR2 protein in rats.	Iron	71-75	transferrin receptor 2	Rattus norvegicus	147-151
32380257-2	2020	Mutations conferring resistance of FPN to hepcidin-mediated degradation cause the iron overload disorder hereditary hemochromatosis type 4.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	42-50
32380257-5	2020	Hfe-/- and FpnC326S mice show increased plasma iron levels and liver iron content, whereas iron overload was more pronounced in FpnC326S compared to Hfe-/- mice.	Iron	47-51	homeostatic iron regulator	Mus musculus	0-3
32380257-5	2020	Hfe-/- and FpnC326S mice show increased plasma iron levels and liver iron content, whereas iron overload was more pronounced in FpnC326S compared to Hfe-/- mice.	Iron	69-73	homeostatic iron regulator	Mus musculus	0-3
32380257-5	2020	Hfe-/- and FpnC326S mice show increased plasma iron levels and liver iron content, whereas iron overload was more pronounced in FpnC326S compared to Hfe-/- mice.	Iron	69-73	homeostatic iron regulator	Mus musculus	0-3
32170997-7	2020	These results suggest that miR-122 agomir can prevent the accumulation of hepatic iron induced by MC-LR, which may be related to the regulation of hepcidin by BMP/SMAD and IL-6/STAT signaling pathways.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	147-155
32609929-6	2020	Fe concentrations were most sensitive towards a reduced supply indicated by increased serum transferrin levels and altered hepatic expression of Fe-related genes.	Iron	0-2	transferrin	Mus musculus	92-103
32729185-2	2020	The purpose of this study was to measure whether iron mediated osteoclast differentiation through regulation of triggering receptor expressed in myeloid cells-2 (Trem-2) expression and the PI3K/Akt signaling pathway.	Iron	49-53	triggering receptor expressed on myeloid cells 2	Mus musculus	162-168
32732975-1	2020	Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	52-60
32732975-1	2020	Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.	Iron	83-87	hepcidin antimicrobial peptide	Mus musculus	52-60
32732975-1	2020	Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.	Iron	136-140	hepcidin antimicrobial peptide	Mus musculus	52-60
32726960-7	2020	We further demonstrate that Y39 is the main contributor to dityrosine formation of Fe-bound NAcalpha-Syn, while Y125 is the main residue involved in dityrosine crosslinks in unmetalated NAcalpha-Syn.	Iron	83-85	synemin	Homo sapiens	101-104
32726960-8	2020	Our results confirm that iron coordination has a global effect on NAcalpha-Syn structure and reactivity.	Iron	25-29	synemin	Homo sapiens	75-78
32722467-3	2020	This study shows that after the aeration and the oxidation with Cl2 and H2O2, the increasing content of dissolved hydrophilic organic substances containing aromatic rings in the raw water reduced the effectiveness of Fe(II) oxidation and the effectiveness of iron removal during the sedimentation process.	Iron	259-263	endogenous retrovirus group W member 5	Homo sapiens	64-67
32604074-9	2020	We targeted the CA3 area of the hippocampus in adult rats and demonstrate that iron microdeposits are remarkably stable and persist up to 10 months post-deposition.	Iron	79-83	carbonic anhydrase 3	Rattus norvegicus	16-19
32707771-0	2020	Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults.	Iron	21-25	brain derived neurotrophic factor	Homo sapiens	81-85
32707771-2	2020	Iron and the antioxidant curcumin have been shown to influence BDNF homeostasis.	Iron	0-4	brain derived neurotrophic factor	Homo sapiens	63-67
32707771-6	2020	The addition of curcumin to iron supplementation may therefore provide a novel approach to further enhance the benefits associated with increased BDNF levels.	Iron	28-32	brain derived neurotrophic factor	Homo sapiens	146-150
32578990-4	2020	We find that the magnetic anisotropy and spin relaxation dynamics of the Fe atom within the complexes remain unperturbed in comparison to well-isolated Fe atoms.	Iron	73-75	spindlin 1	Homo sapiens	41-45
32677981-2	2020	Ferritin Light Chain (FTL) is one of the iron metabolism regulators and is overexpressed in glioma.	Iron	41-45	ferritin light chain	Homo sapiens	0-20
32677981-2	2020	Ferritin Light Chain (FTL) is one of the iron metabolism regulators and is overexpressed in glioma.	Iron	41-45	ferritin light chain	Homo sapiens	22-25
32152203-6	2020	RESULTS: By investigating PCPG cells with low SDHB levels, we show that pseudohypoxia resulted in elevated expression of iron transport proteins, including transferrin (TF), transferrin receptor 2 (TFR2) and the divalent metal transporter 1 (SLC11A2; DMT1), leading to iron accumulation.	Iron	121-125	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	46-50
32646002-4	2020	The over-increase of iron was achieved using phenylhydrazine, a strong oxidant that causes oxidative stress within erythrocytes, resulting in oxidation of oxyhemoglobin and leading to the formation of methemoglobin, which is subsequently converted into irreversible hemichromes (iron (III) compounds).	Iron	21-25	hemoglobin subunit gamma 2	Homo sapiens	201-214
32240305-0	2020	Identification of client iron-sulfur proteins of the chloroplastic NFU2 transfer protein in Arabidopsis thaliana.	Iron	25-29	NIFU-like protein 2	Arabidopsis thaliana	67-71
32199885-0	2020	Cellular iron sensing and regulation: Nuclear IRP1 extends a classic paradigm.	Iron	9-13	Iron regulatory protein 1A	Drosophila melanogaster	46-50
32199885-4	2020	Recent work in Drosophila, however, shows that holo-IRP1 can also translocate to the nucleus, where it appears to downregulate iron metabolism genes, preparing the cell for a decline in iron uptake.	Iron	127-131	Iron regulatory protein 1A	Drosophila melanogaster	52-56
32199885-4	2020	Recent work in Drosophila, however, shows that holo-IRP1 can also translocate to the nucleus, where it appears to downregulate iron metabolism genes, preparing the cell for a decline in iron uptake.	Iron	186-190	Iron regulatory protein 1A	Drosophila melanogaster	52-56
32199885-7	2020	Furthermore, we propose that ferritin ferroxidase activity participates in the repair of the IRP1 [3Fe4S] cluster leading to the hypothesis that cytosolic ferritin directly contributes to cellular iron sensing.	Iron	197-201	Iron regulatory protein 1A	Drosophila melanogaster	93-97
32444136-0	2020	Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	36-44
32444136-2	2020	Iron metabolism and its master regulator, hepcidin, are known to regulate cell proliferation and inflammation, but their direct role in the pathophysiology of lupus nephritis remains under-investigated.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	42-50
32444136-4	2020	Hepcidin treatment reduced renal iron accumulation, systemic and intrarenal cytokines, and renal immune cell infiltration, independent of glomerular immune complex deposits and circulating autoantibodies.	Iron	33-37	hepcidin antimicrobial peptide	Mus musculus	0-8
32444136-5	2020	Hepcidin increased renal H-ferritin (a ferroxidase), reduced expression of free iron dependent DNA synthesis enzymes, Ribonucleotide Reductase 1 and 2, and intra-renal macrophage proliferation.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	0-8
32444136-9	2020	Thus, our findings provide a proof-of-concept that targeting cellular iron metabolism with hepcidin represents a promising therapeutic strategy in lupus nephritis.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	91-99
32366640-7	2020	This reduction was abolished in the iron-regulated transporter1 (Atirt1) mutant of Arabidopsis (Arabidopsis thaliana), and pak choi pretreated with HRW showed decreased BcIRT1 transcript levels.	Iron	36-40	iron-regulated transporter 1	Arabidopsis thaliana	65-71
32655575-13	2020	Finally, we reported that iron overload occurred in 31% of patients with membrane defects, in ~60% of CDAII cases, and in up to 82% of PKD patients (defined by MRI liver iron concentration >4 mg Fe/gdw).	Iron	26-30	protein kinase D1	Homo sapiens	135-138
32655575-13	2020	Finally, we reported that iron overload occurred in 31% of patients with membrane defects, in ~60% of CDAII cases, and in up to 82% of PKD patients (defined by MRI liver iron concentration >4 mg Fe/gdw).	Iron	170-174	protein kinase D1	Homo sapiens	135-138
32575507-1	2020	Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including transporting hydrophobic ligands across cell membranes, modulating immune responses, maintaining iron homeostasis, and promoting epithelial cell differentiation.	Iron	192-196	lipocalin 2	Homo sapiens	0-11
32575507-1	2020	Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including transporting hydrophobic ligands across cell membranes, modulating immune responses, maintaining iron homeostasis, and promoting epithelial cell differentiation.	Iron	192-196	lipocalin 2	Homo sapiens	13-17
32486640-0	2020	Effect of Crystal Symmetry on the Spin States of Fe3+ and Vibration Modes in Lead-Free Double Perovskite Cs2AgBi(Fe)Br6.	Iron	49-51	spindlin 1	Homo sapiens	34-38
32044626-7	2020	The presence of P25 under visible light irradiation could significantly accelerate SDZ degradation at small amount of iron precursors, mainly via promoting the Fe2+/Fe3+ cycling by the photoelectrons.	Iron	118-122	tubulin polymerization promoting protein	Homo sapiens	16-19
32379419-3	2020	Based on our previous findings that up-regulation of divalent metal transporter 1 (DMT1) accounted for the nigral iron accumulation in PD, this raised the question whether alpha-Syn disturbed iron homeostasis by modulating DMT1 expression.	Iron	192-196	synemin	Homo sapiens	178-181
32351167-5	2020	Heterologous expression of an Arabidopsis thaliana monothiol glutaredoxin S17 (GRXS17) suppresses the over-accumulation of iron in the Saccharomyces cerevisiae Grx3/Grx4 mutant and disruption of GRXS17 causes plant sensitivity to exogenous oxidants and iron deficiency stress.	Iron	123-127	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	160-164
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	iron-regulated transporter 1	Arabidopsis thaliana	161-165
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	96-100	iron-regulated transporter 1	Arabidopsis thaliana	161-165
32032734-0	2020	Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function.	Iron	13-17	ATPase cation transporting 13A2	Homo sapiens	50-57
32032734-2	2020	Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential pathogenesis associated with the ATP13A2 mutation.	Iron	33-37	ATPase cation transporting 13A2	Homo sapiens	170-177
32032734-2	2020	Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential pathogenesis associated with the ATP13A2 mutation.	Iron	82-86	ATPase cation transporting 13A2	Homo sapiens	170-177
32032734-3	2020	Previously we demonstrated that functional losses of ATP13A2 disrupt the lysosome"s ability to store excess iron, leading to reduce survival of dopaminergic neuronal cells.	Iron	108-112	ATPase cation transporting 13A2	Homo sapiens	53-60
32335809-7	2020	Iron overload is also associated with increased IL-10 and lower CCL11 levels, but these alterations are not significantly associated with depression.	Iron	0-4	interleukin 10	Homo sapiens	48-53
32596989-3	2020	In this study, we compared the highly iron-overloaded hepcidin knockout mice (HKO) to their iron-sufficient wild-type (WT) littermates in a model of sterile acute lung injury (ALI) induced by treatment with oropharyngeal (OP) LPS.	Iron	38-42	hepcidin antimicrobial peptide	Mus musculus	54-62
32460794-0	2020	CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.	Iron	72-76	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	0-6
32460794-0	2020	CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.	Iron	72-76	calcium/calmodulin-dependent protein kinase IV	Mus musculus	7-12
32460794-2	2020	Therefore, iron is transported in a redox-safe state by a serum glycoprotein - transferrin (TF).	Iron	11-15	transferrin	Mus musculus	79-90
32460794-2	2020	Therefore, iron is transported in a redox-safe state by a serum glycoprotein - transferrin (TF).	Iron	11-15	transferrin	Mus musculus	92-94
32460794-3	2020	Different organs acquire iron from the systemic circulation through a tightly regulated mechanism at the blood-tissue interface which involves receptor-mediated internalization of TF.	Iron	25-29	transferrin	Mus musculus	180-182
32460794-4	2020	Thus, abnormal TF trafficking may lead to iron dyshomeostasis associated with several diseases including neurodegeneration.	Iron	42-46	transferrin	Mus musculus	15-17
32460794-10	2020	Therefore, it was hypothesized that CAMKK2-CAMK4 signaling regulates receptor-mediated TF trafficking and iron homeostasis which may be responsible for the neuronal malfunction observed in CAMKK2- or CAMK4-deficient mice.	Iron	106-110	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	36-42
32460794-10	2020	Therefore, it was hypothesized that CAMKK2-CAMK4 signaling regulates receptor-mediated TF trafficking and iron homeostasis which may be responsible for the neuronal malfunction observed in CAMKK2- or CAMK4-deficient mice.	Iron	106-110	calcium/calmodulin-dependent protein kinase IV	Mus musculus	43-48
32460794-10	2020	Therefore, it was hypothesized that CAMKK2-CAMK4 signaling regulates receptor-mediated TF trafficking and iron homeostasis which may be responsible for the neuronal malfunction observed in CAMKK2- or CAMK4-deficient mice.	Iron	106-110	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	189-195
32460794-10	2020	Therefore, it was hypothesized that CAMKK2-CAMK4 signaling regulates receptor-mediated TF trafficking and iron homeostasis which may be responsible for the neuronal malfunction observed in CAMKK2- or CAMK4-deficient mice.	Iron	106-110	calcium/calmodulin-dependent protein kinase IV	Mus musculus	200-205
32460794-11	2020	METHODS: CAMK4-/- mouse was used to study tissue-specific turnover of TF, TF-receptor (TFRC) and iron.	Iron	97-101	calcium/calmodulin-dependent protein kinase IV	Mus musculus	9-14
32499904-6	2020	This report suggests that BMT using immunosuppressive conditioning regimen may be a feasible and effective treatment for patients with severe PKD with iron overload.	Iron	151-155	protein kinase D1	Homo sapiens	142-145
32352138-7	2020	alpha and SA values have been measured using the dicyano-bis(1,10-phenanthroline) iron(ii) complex (Fe) as HBD probe.	Iron	100-102	HBD	Homo sapiens	107-110
32301607-8	2020	We propose that this structural distortion contributes to the trapping of iron in its high-spin state.	Iron	74-78	spindlin 1	Homo sapiens	91-95
31990410-4	2020	Expression of the iron regulatory peptide hepcidin is negatively regulated by the serine protease TMPRSS6.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	42-50
31990410-5	2020	Hepcidin induction by siRNA-mediated inhibition of TMPRSS6 expression reduces iron availability and induces iron deficiency.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	0-8
32243649-0	2020	Fibroblast growth factor 23 mediates the association between iron deficiency and mortality in worsening heart failure.	Iron	61-65	fibroblast growth factor 23	Homo sapiens	0-27
32006009-3	2020	OBJECTIVE: This study aimed to examine whether changes in iron status from an iron-biofortified bean intervention affect work efficiency.	Iron	58-62	brain expressed associated with NEDD4 1	Homo sapiens	96-100
32006009-3	2020	OBJECTIVE: This study aimed to examine whether changes in iron status from an iron-biofortified bean intervention affect work efficiency.	Iron	78-82	brain expressed associated with NEDD4 1	Homo sapiens	96-100
32083318-3	2020	Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function.	Iron	0-4	transferrin receptor 2	Mus musculus	59-81
32083318-3	2020	Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function.	Iron	0-4	transferrin receptor 2	Mus musculus	83-87
32083318-3	2020	Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function.	Iron	0-4	homeostatic iron regulator	Mus musculus	133-136
32083318-3	2020	Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function.	Iron	43-47	transferrin receptor 2	Mus musculus	59-81
32083318-3	2020	Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function.	Iron	43-47	transferrin receptor 2	Mus musculus	83-87
32083318-3	2020	Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airway fibrosis and reduced lung function.	Iron	117-121	homeostatic iron regulator	Mus musculus	133-136
32186328-5	2020	It was concluded that HGF protects PC12 cells against OGD/R-induced injury mainly by reducing cell iron contents via the up-regulation of Fpn1 and increased Fpn1-mediated iron export from cells.	Iron	99-103	hepatocyte growth factor	Rattus norvegicus	22-25
32186328-5	2020	It was concluded that HGF protects PC12 cells against OGD/R-induced injury mainly by reducing cell iron contents via the up-regulation of Fpn1 and increased Fpn1-mediated iron export from cells.	Iron	171-175	hepatocyte growth factor	Rattus norvegicus	22-25
32186328-6	2020	Our findings suggested that HGF may also be able to ameliorate OGD/R or I/R-induced overloading of brain iron by promoting Fpn1 expression.	Iron	105-109	hepatocyte growth factor	Rattus norvegicus	28-31
32514392-1	2020	Objective: Hepcidin deficiency is known to cause body iron accumulation and bone microarchitecture defects, but the exact underlying mechanisms of hepcidin deficiency-induced bone loss remain unclear.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	11-19
32514392-11	2020	Results: We found that Hepcidin-KO mice exhibited iron accumulation and bone loss compared with WT mice.	Iron	50-54	hepcidin antimicrobial peptide	Mus musculus	23-31
32387912-7	2020	The NtSAT4 overexpressor lines showed a significantly higher amount of iron (Fe) translocation from roots to shoots compared with nontransformed plants.	Iron	71-75	serine acetyltransferase 1, chloroplastic-like	Nicotiana tabacum	4-10
32387912-7	2020	The NtSAT4 overexpressor lines showed a significantly higher amount of iron (Fe) translocation from roots to shoots compared with nontransformed plants.	Iron	77-79	serine acetyltransferase 1, chloroplastic-like	Nicotiana tabacum	4-10
31842001-4	2020	Scanning tunneling microscope/spectroscopy (STM/STS) revealed the presence of Fe atoms near sulfur atoms and asymmetric spectra.	Iron	78-80	sulfotransferase family 1A member 3	Homo sapiens	44-47
32296076-3	2020	Here we report extensive density-functional theory (DFT) calculations and molecular dynamics simulations that show effects of iron (including its coordinate mode and/or spin state) on the dynamics of this reaction: considerably enhancing dynamically stepwise process, broadening entrance channel and narrowing exit channel from concerted asynchronous transition states.	Iron	126-130	spindlin 1	Homo sapiens	169-173
33659548-1	2020	Heme oxygenase-1 (HO-1) is a stress responsive enzyme that metabolizes heme and releases free iron, carbon monoxide (CO), and biliverdin (BV), which rapidly undergoes conversion to bilirubin (BL).	Iron	94-98	heme oxygenase 1	Rattus norvegicus	0-16
33659548-1	2020	Heme oxygenase-1 (HO-1) is a stress responsive enzyme that metabolizes heme and releases free iron, carbon monoxide (CO), and biliverdin (BV), which rapidly undergoes conversion to bilirubin (BL).	Iron	94-98	heme oxygenase 1	Rattus norvegicus	18-22
32368394-4	2020	Ferroptosis is a new defined iron-dependent form of nonapoptotic cell death, which is closely related to Kras mutation.	Iron	29-33	KRAS proto-oncogene, GTPase	Homo sapiens	105-109
32044184-2	2020	We are interested in HSP70 induction capability of an antitumor antibiotic bleomycin which produces oxidative stress by iron chelate formation and oxygen activation in a cell.	Iron	120-124	heat shock protein family A (Hsp70) member 4	Homo sapiens	21-26
31883180-13	2020	The present results provide in vivo and in vitro evidence that microglial glutamate release in SALS spinal cords is enhanced by intracellular soluble iron accumulation-induced activation of ACO1 and TACE and by increased extracellular TNFalpha-stimulated GLS-C upregulation, and suggest a positive feedback mechanism to maintain increased intracellular soluble iron levels, involving TNFalpha, hepcidin, and FPN.	Iron	150-154	aconitase 1	Mus musculus	190-194
32188787-6	2020	Next, we show that the iron transporter Tsf1 is induced by infections downstream of the Toll and Imd pathways and is necessary for iron relocation from the hemolymph to the fat body.	Iron	23-27	Toll	Drosophila melanogaster	88-92
32054685-0	2020	Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload.	Iron	109-113	transferrin receptor 2	Mus musculus	27-49
32054685-1	2020	Transferrin receptor 2 (TFR2) is a transmembrane protein expressed mainly in hepatocytes and in developing erythroid cells and is an important focal point in systemic iron regulation.	Iron	167-171	transferrin receptor 2	Mus musculus	0-22
32054685-1	2020	Transferrin receptor 2 (TFR2) is a transmembrane protein expressed mainly in hepatocytes and in developing erythroid cells and is an important focal point in systemic iron regulation.	Iron	167-171	transferrin receptor 2	Mus musculus	24-28
32054685-2	2020	Loss of TFR2 function results in a rare form of the iron-overload disease hereditary hemochromatosis.	Iron	52-56	transferrin receptor 2	Mus musculus	8-12
32054685-3	2020	Although TFR2 in the liver has been shown to be important for regulating iron homeostasis in the body, TFR2"s function in erythroid progenitors remains controversial.	Iron	73-77	transferrin receptor 2	Mus musculus	9-13
32052980-0	2020	Spin Regulation on 2D Pd-Fe-Pt Nanomeshes Promotes Fuels Electrooxidations.	Iron	22-30	spindlin 1	Homo sapiens	0-4
32052980-2	2020	Herein, we demonstrate that spin engineering of trimetallic Pd-Fe-Pt nanomeshes (NMs) can achieve superior enhancement for fuels electrooxidations.	Iron	60-68	spindlin 1	Homo sapiens	28-32
32373202-4	2020	Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11).	Iron	27-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	231-234
32373202-4	2020	Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11).	Iron	27-31	cyclin D1	Mus musculus	236-245
32373202-4	2020	Chronic exposure to excess iron induced epithelial-mesenchymal transition (EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes (p21, cyclin D1, Bax, SLC7A11).	Iron	27-31	BCL2-associated X protein	Mus musculus	247-250
31236816-7	2020	After 7 weeks, compared with the control group, the zinc and magnesium contents; superoxide dismutase, glutathione peroxidase, and catalase activities; and synaptophysin and Bcl-2 gene expressions in the iron overload group were significantly decreased, whereas the iron, calcium contents, and malondialdehyde contents; TUNEL-positive cell numbers; and Fas and Bax gene expressions were significantly increased.	Iron	204-208	synaptophysin	Rattus norvegicus	156-169
32003373-4	2020	The OHRB consortium was found to contain endogenous iron- and sulfate-reducing bacteria (FeRB and SRB).	Iron	52-56	chaperonin containing TCP1 subunit 4	Homo sapiens	98-101
31962216-5	2020	Compared to conventional Ni catalysts, the Ni-Fe bimetallic catalysts can significantly increase the H2/CO ratio in the produced gas with high gas production yield.	Iron	46-48	relaxin 2	Homo sapiens	101-106
32121405-0	2020	JNK/p66Shc/ITCH Signaling Pathway Mediates Angiotensin II-induced Ferritin Degradation and Labile Iron Pool Increase.	Iron	98-102	mitogen-activated protein kinase 8	Mus musculus	0-3
32121405-0	2020	JNK/p66Shc/ITCH Signaling Pathway Mediates Angiotensin II-induced Ferritin Degradation and Labile Iron Pool Increase.	Iron	98-102	SHC adaptor protein 1	Bos taurus	4-10
32121405-4	2020	We hypothesized that Ang II-induced ferritin degradation and an increase in the labile iron pool are mediated by the c-Jun N-terminal kinase (JNK)/p66Shc/ITCH signaling pathway.	Iron	87-91	mitogen-activated protein kinase 8	Mus musculus	142-145
32121405-4	2020	We hypothesized that Ang II-induced ferritin degradation and an increase in the labile iron pool are mediated by the c-Jun N-terminal kinase (JNK)/p66Shc/ITCH signaling pathway.	Iron	87-91	SHC adaptor protein 1	Bos taurus	147-153
32121405-10	2020	These observations suggest that Ang II-induced ferritin degradation and, hence, elevation of the levels of highly reactive iron, are mediated by the JNK/p66Shc/ITCH signaling pathway.	Iron	123-127	mitogen-activated protein kinase 8	Mus musculus	149-152
32121405-10	2020	These observations suggest that Ang II-induced ferritin degradation and, hence, elevation of the levels of highly reactive iron, are mediated by the JNK/p66Shc/ITCH signaling pathway.	Iron	123-127	SHC adaptor protein 1	Bos taurus	153-159
32121231-0	2020	Iron, Zinc and Phytic Acid Retention of Biofortified, Low Phytic Acid, and Conventional Bean Varieties When Preparing Common Household Recipes.	Iron	0-4	brain expressed associated with NEDD4 1	Homo sapiens	88-92
31899794-2	2020	Hepcidin suppression allows for the mobilization of iron to the bone marrow for the production of red blood cells.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	0-8
32080266-0	2020	H-Ferritin is essential for macrophages" capacity to store or detoxify exogenously added iron.	Iron	89-93	ferritin heavy polypeptide 1	Mus musculus	0-10
32080266-6	2020	In this work, we investigated the role played by H-ferritin in the macrophages" ability to respond to immune stimuli and to deal with exogenously added iron.	Iron	152-156	ferritin heavy polypeptide 1	Mus musculus	49-59
32080266-12	2020	These data indicate that H-ferritin modulates macrophage response to immune stimuli and that it plays an essential role in protection against iron-induced oxidative stress and cell death.	Iron	142-146	ferritin heavy polypeptide 1	Mus musculus	25-35
31676164-7	2020	These results demonstrated that BTS knockdown improved Cd tolerance and accumulation in plants by improving Fe nutrition; thus, the knockdown of BTS via biotechnological pathways may represent a valuable strategy for the improvement in the efficiency of Cd phytoremediation.	Iron	108-110	zinc finger protein-like protein	Arabidopsis thaliana	32-35
31676164-7	2020	These results demonstrated that BTS knockdown improved Cd tolerance and accumulation in plants by improving Fe nutrition; thus, the knockdown of BTS via biotechnological pathways may represent a valuable strategy for the improvement in the efficiency of Cd phytoremediation.	Iron	108-110	zinc finger protein-like protein	Arabidopsis thaliana	145-148
32075143-6	2020	The samples are paramagnetic at room temperature, but they undergo a spin-glass transition when the temperature drops below 75 K. The magnetic frustration is attributed to the competition of magnetic interactions among the iron moments.	Iron	223-227	spindlin 1	Homo sapiens	69-73
32075143-7	2020	There are a superexchange interaction and an indirect exchange interaction that is provided by the spin (and charge) itinerant carriers in a spin-polarized band situated in the vicinity of the Fermi level of the Fe-doped ZnO semiconductor.	Iron	193-195	spindlin 1	Homo sapiens	99-103
32075143-7	2020	There are a superexchange interaction and an indirect exchange interaction that is provided by the spin (and charge) itinerant carriers in a spin-polarized band situated in the vicinity of the Fermi level of the Fe-doped ZnO semiconductor.	Iron	193-195	spindlin 1	Homo sapiens	141-145
31896574-7	2020	We defined Aft1- and Yap1-dependent transcriptional sites in the MMT1 promoter that are necessary for low iron- or oxidant-mediated MMT1 expression.	Iron	106-110	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	11-15
31896574-9	2020	Our findings reveal that both MMT1 and MMT2 are induced under low-iron conditions and that the low-iron regulator Aft1 is required for this induction.	Iron	66-70	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	114-118
31896574-9	2020	Our findings reveal that both MMT1 and MMT2 are induced under low-iron conditions and that the low-iron regulator Aft1 is required for this induction.	Iron	99-103	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	114-118
31896574-10	2020	We further uncover an Aft1-binding site in the MMT1 promoter sufficient for inducing MMT1 transcription and identify an MMT2 promoter region required for low-iron induction.	Iron	158-162	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	22-26
31800957-2	2020	However, excessive hepcidin suppression contributes to iron overload in beta-thalassemia.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	19-27
32023254-8	2020	CONCLUSIONS/SIGNIFICANCE: In monocytes/macrophages of PKDL cases, enhancement of the iron influx gateways (TfR, CD163, DMT-1 and Lcn-2) possibly accounted for the enhanced LIP.	Iron	85-89	lipocalin 2	Homo sapiens	129-134
31661462-10	2020	This placental adaptation that prioritizes placental iron is mediated by iron regulatory protein 1 (IRP1) and is important for the maintenance of mitochondrial respiration, thus ultimately protecting the fetus from the potentially dire consequences of generalized placental dysfunction.	Iron	53-57	aconitase 1	Mus musculus	73-98
31661462-10	2020	This placental adaptation that prioritizes placental iron is mediated by iron regulatory protein 1 (IRP1) and is important for the maintenance of mitochondrial respiration, thus ultimately protecting the fetus from the potentially dire consequences of generalized placental dysfunction.	Iron	53-57	aconitase 1	Mus musculus	100-104
31724192-8	2020	In mice, Nmbr was induced by chronic dietary iron overload in the liver, gut, pancreas, spleen, and skeletal muscle, while Nmb was downregulated in gut, pancreas and spleen.	Iron	45-49	neuromedin B receptor	Mus musculus	9-13
31908024-5	2020	Under iron depletion-induced stress, FKBP8 was recruited to the site of mitochondrial division through budding and colocalized with LC3.	Iron	6-10	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	132-135
31652009-0	2020	Oral Iron Replacement Normalizes Fibroblast Growth Factor 23 in Iron-Deficient Patients With Autosomal Dominant Hypophosphatemic Rickets.	Iron	5-9	fibroblast growth factor 23	Homo sapiens	33-60
31815268-6	2020	Among the 367 unique plasma proteins identified, 7 proteins were confirmed as differentially abundant between Atp7b-/- mice and wild-type littermates, and were directly linked to WD pathophysiology (regeneration of liver parenchyma, plasma iron depletion, etc.).	Iron	240-244	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	110-115
32013168-0	2020	Iron(II) Spin Crossover Complexes with 4,4"-Dipyridylethyne-Crystal Structures and Spin Crossover with Hysteresis.	Iron	0-8	spindlin 1	Homo sapiens	9-13
32013168-0	2020	Iron(II) Spin Crossover Complexes with 4,4"-Dipyridylethyne-Crystal Structures and Spin Crossover with Hysteresis.	Iron	0-8	spindlin 1	Homo sapiens	83-87
32013168-1	2020	Three new iron(II) 1D coordination polymers with cooperative spin crossover behavior showing thermal hysteresis loops were synthesized using N2O2 Schiff base-like equatorial ligands and 4,4"-dipyridylethyne as a bridging, rigid axial linker.	Iron	10-18	spindlin 1	Homo sapiens	61-65
31826608-0	2020	Polyphenolic Profiles of Yellow Bean Seed Coats and Their Relationship to Iron Bioavailability.	Iron	74-78	brain expressed associated with NEDD4 1	Homo sapiens	32-36
31826608-5	2020	Thirteen of the yellow bean seed types contained high concentrations (up to 35.3 +- 2.7 micromol/g) of kaempferol 3-glucoside (k 3-g), a known promoter of iron uptake.	Iron	155-159	brain expressed associated with NEDD4 1	Homo sapiens	23-27
31909611-0	2020	Extension of Azine-Triazole Synthesis to Azole-Triazoles Reduces Ligand Field, Leading to Spin Crossover in Tris-L Fe(II).	Iron	115-121	spindlin 1	Rattus norvegicus	90-94
31909611-2	2020	The tris-L FeII complexes of the azine-triazoles are consistently low spin (LS).	Iron	11-15	spindlin 1	Rattus norvegicus	70-74
31559819-8	2020	Expression of biomarkers related to the neuronal differentiation of TMSCs, including NFM, MAP2, GFAP, NURR1, NSE, and TUBB3, increased 4-35-fold at the mRNA level in the Fe3+-containing system compared to that of the system without Fe3+.	Iron	170-174	neurofilament medium chain	Homo sapiens	85-88
31559819-8	2020	Expression of biomarkers related to the neuronal differentiation of TMSCs, including NFM, MAP2, GFAP, NURR1, NSE, and TUBB3, increased 4-35-fold at the mRNA level in the Fe3+-containing system compared to that of the system without Fe3+.	Iron	170-174	microtubule associated protein 2	Homo sapiens	90-94
31559819-8	2020	Expression of biomarkers related to the neuronal differentiation of TMSCs, including NFM, MAP2, GFAP, NURR1, NSE, and TUBB3, increased 4-35-fold at the mRNA level in the Fe3+-containing system compared to that of the system without Fe3+.	Iron	170-174	glial fibrillary acidic protein	Homo sapiens	96-100
31559819-8	2020	Expression of biomarkers related to the neuronal differentiation of TMSCs, including NFM, MAP2, GFAP, NURR1, NSE, and TUBB3, increased 4-35-fold at the mRNA level in the Fe3+-containing system compared to that of the system without Fe3+.	Iron	170-174	nuclear receptor subfamily 4 group A member 2	Homo sapiens	102-107
31689671-7	2020	However, Fe/Al-P and Po continuously increased in the lakes from the economic backward area over the last few decades, which is largely due to enhanced point sources of pollution and an increase in the intensity of agricultural practices.	Iron	9-11	PDZ and LIM domain 3	Homo sapiens	12-16
31689671-8	2020	As a potential P source, the massive accumulation of Fe/Al-P and Po would be released into the overlying water to further facilitate eutrophication via increasing pH and alkaline phosphatase and decreasing in the dissolved oxygen concentration.	Iron	53-55	PDZ and LIM domain 3	Homo sapiens	56-60
32256196-0	2020	Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers.	Iron	100-104	interleukin 18	Homo sapiens	80-85
32564749-8	2020	In response, host immune cells produce lipocalin 2 to prevent bacterial reuptake of siderophores loaded with iron.	Iron	109-113	lipocalin 2	Homo sapiens	39-50
31401754-9	2020	Copper and Fe in Gp-1 were enriched in the Carajas basin and are associated with metavolcanic rocks and banded-iron formations, respectively.	Iron	11-13	GTP binding protein 1	Homo sapiens	17-21
31401754-9	2020	Copper and Fe in Gp-1 were enriched in the Carajas basin and are associated with metavolcanic rocks and banded-iron formations, respectively.	Iron	111-115	GTP binding protein 1	Homo sapiens	17-21
31519999-0	2020	FGF23 at the crossroads of phosphate, iron economy and erythropoiesis.	Iron	38-42	fibroblast growth factor 23	Homo sapiens	0-5
31519999-2	2020	New research advances demonstrate that FGF23 is also linked to iron economy, inflammation and erythropoiesis.	Iron	63-67	fibroblast growth factor 23	Homo sapiens	39-44
31956757-7	2020	The origin of the significant red shift even at low concentrations of Fe (x = 0.05) is attributed to the strong sp-d exchange interaction originated from the 3d5 electrons of Fe3+.	Iron	70-72	surfactant protein D	Homo sapiens	112-116
31956757-7	2020	The origin of the significant red shift even at low concentrations of Fe (x = 0.05) is attributed to the strong sp-d exchange interaction originated from the 3d5 electrons of Fe3+.	Iron	175-179	surfactant protein D	Homo sapiens	112-116
31539545-5	2019	Iron management proteins lipocalin 2 (LCN2) and ferritin(FTL) exhibited distinct postinjury time courses, where peak LCN2 response preceded, and FTL followed that of HO-1.	Iron	0-4	heme oxygenase 1	Rattus norvegicus	166-170
31837665-6	2019	Such variations lead to a weaker coupling with the substrate along with a different local electronic configuration of the Fe center compared with that of the intact case, which is responsible for the suppression of Kondo resonance and the appearance of spin-flip excitation in the system.	Iron	122-124	spindlin 1	Homo sapiens	253-257
31922861-0	2019	Strain-Induced Spin-Nematic State and Nematic Susceptibility Arising from 2x2 Fe Clusters in KFe_{0.8}Ag_{1.2}Te_{2}.	Iron	78-80	spindlin 1	Homo sapiens	15-19
31922861-3	2019	KFe_{0.8}Ag_{1.2}Te_{2} (K_{5}Fe_{4}Ag_{6}Te_{10}, KFAT) is a local-moment magnet consisting of well-separated 2x2 Fe clusters, and in its ground state the clusters order magnetically, breaking both spin-rotational and time-reversal symmetries.	Iron	1-3	spindlin 1	Homo sapiens	199-203
31922861-3	2019	KFe_{0.8}Ag_{1.2}Te_{2} (K_{5}Fe_{4}Ag_{6}Te_{10}, KFAT) is a local-moment magnet consisting of well-separated 2x2 Fe clusters, and in its ground state the clusters order magnetically, breaking both spin-rotational and time-reversal symmetries.	Iron	30-32	spindlin 1	Homo sapiens	199-203
31922868-0	2019	Ultrasmall Moment Incommensurate Spin Density Wave Order Masking a Ferromagnetic Quantum Critical Point in NbFe_{2}.	Iron	107-111	spindlin 1	Homo sapiens	33-37
31831856-0	2019	Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery.	Iron	78-82	iron-sulfur cluster assembly factor IBA57	Homo sapiens	40-45
31920471-2	2019	Ferritin is a 24 subunit spherical shell protein composed of both light (FTL) and heavy chain (FTH1) subunits, possessing complimentary iron-handling functions and forming three-fold and four-fold pores.	Iron	136-140	ferritin heavy polypeptide 1	Mus musculus	95-99
31920471-4	2019	Hereditary Ferritinopathy (HF) or neuroferritinopathy is an autosomal dominant neurodegenerative disease caused by mutations in the FTL C-terminal sequence, which in turn cause disorder and unraveling at the four-fold pores allowing iron leakage and enhanced formation of toxic, improperly coordinated iron (ICI).	Iron	233-237	ferritin light polypeptide 1	Mus musculus	132-135
31920471-4	2019	Hereditary Ferritinopathy (HF) or neuroferritinopathy is an autosomal dominant neurodegenerative disease caused by mutations in the FTL C-terminal sequence, which in turn cause disorder and unraveling at the four-fold pores allowing iron leakage and enhanced formation of toxic, improperly coordinated iron (ICI).	Iron	302-306	ferritin light polypeptide 1	Mus musculus	132-135
31821458-3	2019	Prior studies show that cytochrome b5 reductase 3 (CYB5R3), known as methemoglobin reductase in erythrocytes, functions in VSM as an sGC heme iron reductase critical for reducing and sensitizing sGC to NO and generating cyclic guanosine monophosphate for vasodilation.	Iron	142-146	cytochrome b5 reductase 3	Mus musculus	24-49
31821458-3	2019	Prior studies show that cytochrome b5 reductase 3 (CYB5R3), known as methemoglobin reductase in erythrocytes, functions in VSM as an sGC heme iron reductase critical for reducing and sensitizing sGC to NO and generating cyclic guanosine monophosphate for vasodilation.	Iron	142-146	cytochrome b5 reductase 3	Mus musculus	51-57
31776249-7	2019	The subgroup IVc bHLH transcription factors, which have previously been shown to regulate bHLH38/39/100/101, coimmunoprecipitate with URI mainly under Fe-deficient conditions, suggesting that it is the phosphorylated form of URI that is capable of forming heterodimers in vivo.	Iron	151-153	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	90-96
31638596-3	2019	The inappropriately low levels of the iron regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron exporter in mammals, leading to organ iron overload and associated morbidities.	Iron	38-42	hepcidin antimicrobial peptide	Mus musculus	62-70
31638596-3	2019	The inappropriately low levels of the iron regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron exporter in mammals, leading to organ iron overload and associated morbidities.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	62-70
31638596-3	2019	The inappropriately low levels of the iron regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron exporter in mammals, leading to organ iron overload and associated morbidities.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	62-70
31638596-3	2019	The inappropriately low levels of the iron regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron exporter in mammals, leading to organ iron overload and associated morbidities.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	62-70
31638596-4	2019	Correction of unbalanced iron absorption and recycling by induction of hepcidin synthesis or treatment with hepcidin mimetics ameliorates beta-thalassemia.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	71-79
31690908-1	2019	The structural, magnetic and Mossbauer spectral properties of a double salt, mixed-valent material, [FeII(3,5-Me2TPM)(TPM)][FeIII(azp)2]ClO4 2MeCN, 1, reveal spin transitions occur at both the metal sites, with hysteresis, indicative of 1 being a double spin crossover material.	Iron	100-146	spindlin 1	Homo sapiens	158-162
31690908-1	2019	The structural, magnetic and Mossbauer spectral properties of a double salt, mixed-valent material, [FeII(3,5-Me2TPM)(TPM)][FeIII(azp)2]ClO4 2MeCN, 1, reveal spin transitions occur at both the metal sites, with hysteresis, indicative of 1 being a double spin crossover material.	Iron	100-146	spindlin 1	Homo sapiens	254-258
31601421-0	2019	Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria).	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	30-38
31601421-6	2019	The negative control of hepcidin on the ferroportin iron exporter appeared strain specific in the CEP mice models tested.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	24-32
31601421-7	2019	Full repression of hepcidin was observed in BALB/c and 129/Sv mice, favoring parenchymal iron overload in the liver.	Iron	89-93	hepcidin antimicrobial peptide	Mus musculus	19-27
31601421-8	2019	Unchanged hepcidin levels in C57BL/6 resulted in retention of iron predominantly in reticuloendothelial tissues.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	10-18
31777540-8	2019	Fe2O3NPs and/or AgNPs decreased paraoxonase 1, antioxidant enzymes, total antioxidant capacity, and reduced glutathione in heart and lung.	Iron	0-4	paraoxonase 1	Rattus norvegicus	32-45
31127639-1	2019	A failure of iron to appropriately regulate liver hepcidin production is central to the pathogenesis of hereditary hemochromatosis.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	50-58
31127639-2	2019	SMAD1/5 transcription factors, activated by bone morphogenetic protein (BMP) signaling, are major regulators of hepcidin production in response to iron; however, the role of SMAD8 and the contribution of SMADs to hepcidin production by other systemic cues remain uncertain.	Iron	147-151	hepcidin antimicrobial peptide	Mus musculus	112-120
30810907-11	2019	Targeted regulation of GMF possibly mediates protein aggregation in microglial homeostasis associated with PD progression through regulation of iron metabolism by modulating NRF2-HO1 and ferritin expression.	Iron	144-148	glia maturation factor beta	Homo sapiens	23-26
31889778-10	2019	Conclusions: Acupuncture can reduce iron accumulation in the SN and protect the loss of dopamine neurons by promoting balanced expression of the iron importer DMT1 and the iron exporter Fpn1.	Iron	145-149	RoBo-1	Rattus norvegicus	159-163
31889778-10	2019	Conclusions: Acupuncture can reduce iron accumulation in the SN and protect the loss of dopamine neurons by promoting balanced expression of the iron importer DMT1 and the iron exporter Fpn1.	Iron	145-149	RoBo-1	Rattus norvegicus	159-163
31610749-6	2019	Elevations of brain Fe and S in particular are consistent with potential ferroptotic, oxidative stress, and altered antioxidant capacity-based mechanisms of CAPs-induced neurotoxicity, supported by observations of increased serum oxidized glutathione and increased neuronal cell death in nucleus accumbens with no corresponding significant increase in caspase-3, in male brains following postnatal CAP exposures.	Iron	20-22	caspase 3	Mus musculus	352-361
31894180-1	2019	Bistable spin crossover complexes such as [Fe{HB(pz)3}2] (pzH = pyrazole) show promise for sensor applications and electrically-controlled data storage units, but exploiting their potential hinges on their integration into a functional environment.	Iron	42-56	spindlin 1	Homo sapiens	9-13
31554636-7	2019	Additionally, the HRI-eIF2alphaP-ATF4 pathway represses mechanistic target of rapamycin complex 1 (mTORC1) signaling, specifically in the erythroid lineage as a feedback mechanism of erythropoietin-stimulated erythropoiesis during iron/heme deficiency.	Iron	231-235	activating transcription factor 4	Homo sapiens	33-37
31712673-0	2019	Three port logic gate using forward volume spin wave interference in a thin yttrium iron garnet film.	Iron	84-88	spindlin 1	Homo sapiens	43-47
31712673-1	2019	We demonstrate a logic gate based on interference of forward volume spin waves (FVSWs) propagating in a 54 nm thick, 100 mum wide yttrium iron garnet waveguide grown epitaxially on a garnet substrate.	Iron	138-142	spindlin 1	Homo sapiens	68-72
31717526-2	2019	Therefore, we assessed iron metabolism and variants in the Homeostatic Iron Regulator gene (HFE) as the major cause of hereditary iron overload in a large cohort of Pi*ZZ subjects without liver comorbidities.	Iron	130-134	homeostatic iron regulator	Mus musculus	92-95
31717526-8	2019	HFE knockout and DTg mice displayed similar extent of iron overload and of fibrosis.	Iron	54-58	homeostatic iron regulator	Mus musculus	0-3
31787896-4	2019	Here, we used a PAE rat model to analyze messenger RNA (mRNA) and protein expression of iron homeostasis genes such as transferrin receptor (TfR), divalent metal transporter (DMT1), ferroportin (FPN1), and ferritin (FT) in brain areas associated with memory formation such as the prefrontal cortex (PFC), ventral tegmental area, and hippocampus.	Iron	88-92	RoBo-1	Rattus norvegicus	175-179
31921964-0	2019	Linking the low-density lipoprotein receptor-binding segment enables the therapeutic 5-YHEDA peptide to cross the blood-brain barrier and scavenge excess iron and radicals in the brain of senescent mice.	Iron	154-158	low density lipoprotein receptor	Mus musculus	12-44
31524964-4	2019	Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3.	Iron	26-30	Janus kinase 2	Rattus norvegicus	143-147
31166618-2	2019	Previous work from our laboratory demonstrated that the microbiota influences systemic iron homeostasis in mouse colitis models by altering inflammation-induced expression of the iron-regulating hormone hepcidin.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	203-211
31166618-2	2019	Previous work from our laboratory demonstrated that the microbiota influences systemic iron homeostasis in mouse colitis models by altering inflammation-induced expression of the iron-regulating hormone hepcidin.	Iron	179-183	hepcidin antimicrobial peptide	Mus musculus	203-211
31166618-3	2019	In the present study, we examined the impact of the gut commensal bacterium Bacteroides fragilis on the expression of the iron exporter ferroportin, the target of hepcidin action, in macrophages, the cell type that plays a pivotal role in iron recycling.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	163-171
31176711-0	2019	Reduced Iron in Diabetic Wounds: An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling.	Iron	8-12	STEAP family member 3	Mus musculus	72-78
30391163-5	2019	In this study we examined the association between mitochondrial iron acquisition and utilization with activity of FECH.	Iron	64-68	ferrochelatase	Mus musculus	114-118
31441171-1	2019	Fes and Fes-related (Fer) protein tyrosine kinases (PTKs) comprise a subfamily of nonreceptor tyrosine kinases characterized by a unique multidomain structure composed of an N-terminal Fer/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain, a central Src homology 2 (SH2) domain, and a C-terminal PTK domain.	Iron	0-3	FER tyrosine kinase	Homo sapiens	21-24
31441171-1	2019	Fes and Fes-related (Fer) protein tyrosine kinases (PTKs) comprise a subfamily of nonreceptor tyrosine kinases characterized by a unique multidomain structure composed of an N-terminal Fer/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain, a central Src homology 2 (SH2) domain, and a C-terminal PTK domain.	Iron	0-3	FER tyrosine kinase	Homo sapiens	185-188
31441171-1	2019	Fes and Fes-related (Fer) protein tyrosine kinases (PTKs) comprise a subfamily of nonreceptor tyrosine kinases characterized by a unique multidomain structure composed of an N-terminal Fer/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain, a central Src homology 2 (SH2) domain, and a C-terminal PTK domain.	Iron	8-11	FER tyrosine kinase	Homo sapiens	21-24
31441171-1	2019	Fes and Fes-related (Fer) protein tyrosine kinases (PTKs) comprise a subfamily of nonreceptor tyrosine kinases characterized by a unique multidomain structure composed of an N-terminal Fer/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain, a central Src homology 2 (SH2) domain, and a C-terminal PTK domain.	Iron	8-11	FER tyrosine kinase	Homo sapiens	185-188
31587557-0	2019	Tracking the Metal-Centered Triplet in Photoinduced Spin Crossover of Fe(phen)32+ with Tabletop Femtosecond M-edge XANES.	Iron	70-80	spindlin 1	Homo sapiens	52-56
31434707-0	2019	Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis.	Iron	20-24	transferrin	Mus musculus	36-47
31434707-0	2019	Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis.	Iron	84-88	transferrin	Mus musculus	36-47
31434707-1	2019	Transferrin, the major plasma iron-binding molecule, interacts with cell-surface receptors to deliver iron, modulates hepcidin expression, and regulates erythropoiesis.	Iron	30-34	transferrin	Mus musculus	0-11
31434707-1	2019	Transferrin, the major plasma iron-binding molecule, interacts with cell-surface receptors to deliver iron, modulates hepcidin expression, and regulates erythropoiesis.	Iron	102-106	transferrin	Mus musculus	0-11
31434707-2	2019	Transferrin binds and releases iron via either or both of 2 homologous lobes (N and C).	Iron	31-35	transferrin	Mus musculus	0-11
31434707-8	2019	Observations in heterozygous mice further support a role for relative N vs C lobe iron occupancy in transferrin-mediated regulation of iron homeostasis and erythropoiesis.	Iron	82-86	transferrin	Mus musculus	100-111
31434707-8	2019	Observations in heterozygous mice further support a role for relative N vs C lobe iron occupancy in transferrin-mediated regulation of iron homeostasis and erythropoiesis.	Iron	135-139	transferrin	Mus musculus	100-111
31402362-2	2019	Here we show that respiratory growth and iron acquisition by the yeast Saccharomyces cerevisiae relies on potassium (K+) compartmentalization to the mitochondria, as well as the vacuole and late endosome via K+/H+ exchangers Mdm38p, Vnx1p and Nhx1p, respectively.	Iron	41-45	Vnx1p	Saccharomyces cerevisiae S288C	233-238
31402362-2	2019	Here we show that respiratory growth and iron acquisition by the yeast Saccharomyces cerevisiae relies on potassium (K+) compartmentalization to the mitochondria, as well as the vacuole and late endosome via K+/H+ exchangers Mdm38p, Vnx1p and Nhx1p, respectively.	Iron	41-45	bifunctional K:H/Na:H antiporter NHX1	Saccharomyces cerevisiae S288C	243-248
31623079-10	2019	Analysis of CNTN2 and BDNF levels as predictors of cord blood iron indices showed a direct correlation between CNTN2 and ferritin in all neonates (n = 79, beta = 1.75, p = 0.02).	Iron	62-66	contactin 2	Homo sapiens	12-17
31623079-10	2019	Analysis of CNTN2 and BDNF levels as predictors of cord blood iron indices showed a direct correlation between CNTN2 and ferritin in all neonates (n = 79, beta = 1.75, p = 0.02).	Iron	62-66	brain derived neurotrophic factor	Homo sapiens	22-26
31614948-6	2019	The nutrient-to-energy ratio for vitamins A, B1, B2, B6, C, folate and minerals Calcium, copper, iron, magnesium, phosphorus, potassium and zinc increased significantly.	Iron	97-101	immunoglobulin kappa variable 5-2	Homo sapiens	33-55
30403147-2	2019	Recent Advances and Critical Issues: Aspects of vascular remodeling induction mechanisms described are associated with shifts in glucose metabolism through the pentose phosphate pathway and increased cytosolic NADPH generation by glucose-6-phosphate dehydrogenase, increased glycolysis generation of cytosolic NADH and lactate, mitochondrial dysfunction associated with superoxide dismutase-2 depletion, changes in reactive oxygen species and iron metabolism, and redox signaling.	Iron	443-447	glucose-6-phosphate dehydrogenase	Homo sapiens	230-263
31066938-9	2019	Higher levels of iron, arsenic, and vanadium were associated with a statistically nonsignificant increased risk of a KRAS wild-type PDAC (OR for higher tertile of arsenic = 3.37, 95% CI 0.98-11.57).	Iron	17-21	KRAS proto-oncogene, GTPase	Homo sapiens	117-121
31298936-1	2019	Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator that favors iron sequestration in the spleen.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	48-56
31298936-1	2019	Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator that favors iron sequestration in the spleen.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	48-56
31298936-1	2019	Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator that favors iron sequestration in the spleen.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	48-56
31298936-2	2019	Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and increases hepatic iron concentration, whereas during secondary iron overload, the hepcidin expression increases together with spleen iron concentration in addition to hepatic iron concentrations increase.	Iron	8-12	hepcidin antimicrobial peptide	Mus musculus	33-41
31298936-2	2019	Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and increases hepatic iron concentration, whereas during secondary iron overload, the hepcidin expression increases together with spleen iron concentration in addition to hepatic iron concentrations increase.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	33-41
31298936-2	2019	Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and increases hepatic iron concentration, whereas during secondary iron overload, the hepcidin expression increases together with spleen iron concentration in addition to hepatic iron concentrations increase.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	33-41
31298936-2	2019	Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and increases hepatic iron concentration, whereas during secondary iron overload, the hepcidin expression increases together with spleen iron concentration in addition to hepatic iron concentrations increase.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	33-41
31298936-2	2019	Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and increases hepatic iron concentration, whereas during secondary iron overload, the hepcidin expression increases together with spleen iron concentration in addition to hepatic iron concentrations increase.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	33-41
31298936-2	2019	Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and increases hepatic iron concentration, whereas during secondary iron overload, the hepcidin expression increases together with spleen iron concentration in addition to hepatic iron concentrations increase.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	33-41
31298936-3	2019	Links between iron metabolism and other metals being suggested, our aim was to investigate, during iron overload, the relationships between the hepatic hepcidin expression level and the hepatic and splenic concentrations of iron, manganese, copper, zinc, and molybdenum, determined using inductively coupled plasma mass spectrometry.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	152-160
31298936-3	2019	Links between iron metabolism and other metals being suggested, our aim was to investigate, during iron overload, the relationships between the hepatic hepcidin expression level and the hepatic and splenic concentrations of iron, manganese, copper, zinc, and molybdenum, determined using inductively coupled plasma mass spectrometry.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	152-160
31298936-3	2019	Links between iron metabolism and other metals being suggested, our aim was to investigate, during iron overload, the relationships between the hepatic hepcidin expression level and the hepatic and splenic concentrations of iron, manganese, copper, zinc, and molybdenum, determined using inductively coupled plasma mass spectrometry.	Iron	99-103	hepcidin antimicrobial peptide	Mus musculus	152-160
31298936-6	2019	Our data suggest that iron, manganese, and molybdenum metabolisms could share mechanisms controlling their distribution that are associated to hepcidin modulation.	Iron	22-26	hepcidin antimicrobial peptide	Mus musculus	143-151
31569434-7	2019	Endosomes with low pH can dissolve iron from AuFe NPs, and thus, the intracellularly released iron ions up-regulate the hypoxia-inducible factor 1alpha and vascular endothelial growth factor (VEGF) expression.	Iron	35-39	vascular endothelial growth factor A	Mus musculus	156-190
31569434-7	2019	Endosomes with low pH can dissolve iron from AuFe NPs, and thus, the intracellularly released iron ions up-regulate the hypoxia-inducible factor 1alpha and vascular endothelial growth factor (VEGF) expression.	Iron	35-39	vascular endothelial growth factor A	Mus musculus	192-196
31569434-7	2019	Endosomes with low pH can dissolve iron from AuFe NPs, and thus, the intracellularly released iron ions up-regulate the hypoxia-inducible factor 1alpha and vascular endothelial growth factor (VEGF) expression.	Iron	94-98	vascular endothelial growth factor A	Mus musculus	156-190
31569434-7	2019	Endosomes with low pH can dissolve iron from AuFe NPs, and thus, the intracellularly released iron ions up-regulate the hypoxia-inducible factor 1alpha and vascular endothelial growth factor (VEGF) expression.	Iron	94-98	vascular endothelial growth factor A	Mus musculus	192-196
31430146-4	2019	Here we report the activation of acetylene gas at a mononuclear tris(phosphino)silyl-iron center, (SiP3)Fe, to give Fe(I) and Fe(II) side-on adducts, including S = 1/2 FeI(eta2-HCCH); the latter is characterized by pulse EPR spectroscopy and DFT calculations.	Iron	104-106	gem nuclear organelle associated protein 7	Homo sapiens	99-103
31430146-5	2019	Reductive protonation reactions with these compounds converge at stable examples of unusual, formally iron(IV) and iron(V) carbyne complexes, as in diamagnetic (SiP3)Fe CCH3 and the paramagnetic cation S = 1/2 [(SiP3)Fe CCH3]+.	Iron	102-106	gem nuclear organelle associated protein 7	Homo sapiens	161-165
31430146-5	2019	Reductive protonation reactions with these compounds converge at stable examples of unusual, formally iron(IV) and iron(V) carbyne complexes, as in diamagnetic (SiP3)Fe CCH3 and the paramagnetic cation S = 1/2 [(SiP3)Fe CCH3]+.	Iron	102-106	gem nuclear organelle associated protein 7	Homo sapiens	212-216
31430146-5	2019	Reductive protonation reactions with these compounds converge at stable examples of unusual, formally iron(IV) and iron(V) carbyne complexes, as in diamagnetic (SiP3)Fe CCH3 and the paramagnetic cation S = 1/2 [(SiP3)Fe CCH3]+.	Iron	115-119	gem nuclear organelle associated protein 7	Homo sapiens	161-165
31430146-5	2019	Reductive protonation reactions with these compounds converge at stable examples of unusual, formally iron(IV) and iron(V) carbyne complexes, as in diamagnetic (SiP3)Fe CCH3 and the paramagnetic cation S = 1/2 [(SiP3)Fe CCH3]+.	Iron	115-119	gem nuclear organelle associated protein 7	Homo sapiens	212-216
31430146-5	2019	Reductive protonation reactions with these compounds converge at stable examples of unusual, formally iron(IV) and iron(V) carbyne complexes, as in diamagnetic (SiP3)Fe CCH3 and the paramagnetic cation S = 1/2 [(SiP3)Fe CCH3]+.	Iron	217-219	gem nuclear organelle associated protein 7	Homo sapiens	161-165
31430146-9	2019	The electronic structures of (SiP3)Fe CCH3 and [(SiP3)Fe CCH3]+ are discussed in comparison to previously characterized, but heterosubstituted, iron carbynes, as well as a hypothetical nitride species, (SiP3)Fe N. Such comparisons are germane to the consideration of formally high-valent, multiply bonded Fe C and/or Fe N intermediates in synthetic or biological catalysis by iron.	Iron	35-37	gem nuclear organelle associated protein 7	Homo sapiens	30-34
31430146-9	2019	The electronic structures of (SiP3)Fe CCH3 and [(SiP3)Fe CCH3]+ are discussed in comparison to previously characterized, but heterosubstituted, iron carbynes, as well as a hypothetical nitride species, (SiP3)Fe N. Such comparisons are germane to the consideration of formally high-valent, multiply bonded Fe C and/or Fe N intermediates in synthetic or biological catalysis by iron.	Iron	54-56	gem nuclear organelle associated protein 7	Homo sapiens	49-53
31430146-9	2019	The electronic structures of (SiP3)Fe CCH3 and [(SiP3)Fe CCH3]+ are discussed in comparison to previously characterized, but heterosubstituted, iron carbynes, as well as a hypothetical nitride species, (SiP3)Fe N. Such comparisons are germane to the consideration of formally high-valent, multiply bonded Fe C and/or Fe N intermediates in synthetic or biological catalysis by iron.	Iron	54-56	gem nuclear organelle associated protein 7	Homo sapiens	49-53
31323261-0	2019	Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.	Iron	38-42	sestrin 2	Mus musculus	21-29
31483921-4	2020	With some types of iron formulation (especially iron carboxymaltose) a particular side-effect has been observed: hypophosphatemia, mediated by FGF23.	Iron	19-23	fibroblast growth factor 23	Homo sapiens	143-148
31483921-5	2020	This review aims to draw attention to this correlation and the contradiction represented by the presence of both positive and negative modulation by FGF23, with the effects induced by its increase even after long-term treatment with iron formulation.	Iron	233-237	fibroblast growth factor 23	Homo sapiens	149-154
31205289-12	2019	Additional research investigating the effect of including iron supplements in STH control programs is warranted.	Iron	58-62	saitohin	Homo sapiens	78-81
31406370-0	2019	A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly.	Iron	41-45	bolA family member 2	Homo sapiens	8-13
31406370-5	2019	The Fe-GSH-bound form of PCBP1 complexes with cytosolic BolA2 via a bridging Fe ligand.	Iron	4-6	bolA family member 2	Homo sapiens	56-61
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	223-227	bolA family member 2	Homo sapiens	34-39
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	223-227	bolA family member 2	Homo sapiens	92-97
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	223-227	bolA family member 2	Homo sapiens	92-97
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	85-87	bolA family member 2	Homo sapiens	34-39
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	85-87	bolA family member 2	Homo sapiens	92-97
31406370-6	2019	Biochemical analysis of PCBP1 and BolA2, in cells and in vitro, indicates that PCBP1-Fe-GSH-BolA2 serves as an intermediate complex required for the assembly of [2Fe-2S] clusters on BolA2-Glrx3, thereby linking the ferrous iron and Fe-S distribution systems in cells.	Iron	85-87	bolA family member 2	Homo sapiens	92-97
31413196-0	2019	Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling.	Iron	55-59	zinc finger protein-like protein	Arabidopsis thaliana	12-18
31413196-3	2019	Here we describe the function of 2 partially redundant E3 ubiquitin ligases, BRUTUS-LIKE1 (BTSL1) and BTSL2, in Arabidopsis thaliana and provide evidence that they target the transcription factor FIT, a key regulator of Fe uptake, for degradation.	Iron	220-222	zinc finger protein-like protein	Arabidopsis thaliana	77-89
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	19-49
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	51-55
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	19-27
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	19-49
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	51-55
31270208-3	2019	Here, we show that hepcidin antimicrobial peptide (Hamp), encoding the hormone hepcidin essential for iron homeostasis and regulated by dietary iron and inflammation, is a target gene of the two SREBP isoforms SREBP-1a/c.	Iron	144-148	hepcidin antimicrobial peptide	Mus musculus	19-27
31270208-8	2019	Conversely, liver-specific depletion of the nuclear forms of SREBPs, as in SREBP cleavage-activating protein knockout mice, impaired lipopolysaccharide-induced up-regulation of hepatic Hamp Together, these results indicate that the SREBP-1a/c transcription regulators activate hepcidin expression and thereby contribute to the control of mammalian iron metabolism.	Iron	348-352	hepcidin antimicrobial peptide	Mus musculus	185-189
31265281-0	2019	Ab Initio Calculations for Spin-Gaps of Non-Heme Iron Complexes.	Iron	49-53	spindlin 1	Homo sapiens	27-31
31101625-10	2019	Key molecules involved in iron recycling were also highly expressed in BM F4/80+Epor-eGFP+ macrophages, suggesting that EBI macrophages may provide an iron source for erythropoiesis within this niche.	Iron	26-30	adhesion G protein-coupled receptor E1	Mus musculus	74-79
31101625-10	2019	Key molecules involved in iron recycling were also highly expressed in BM F4/80+Epor-eGFP+ macrophages, suggesting that EBI macrophages may provide an iron source for erythropoiesis within this niche.	Iron	151-155	adhesion G protein-coupled receptor E1	Mus musculus	74-79
31374868-0	2019	An In Vivo (Gallus gallus) Feeding Trial Demonstrating the Enhanced Iron Bioavailability Properties of the Fast Cooking Manteca Yellow Bean (Phaseolus vulgaris L.).	Iron	68-72	brain expressed associated with NEDD4 1	Gallus gallus	135-139
31374868-6	2019	Iron status and iron bioavailability was assessed by the capacity of a bean based diet to generate and maintain total body hemoglobin iron (Hb-Fe) during a 6 week in vivo (Gallus gallus) feeding trial.	Iron	134-138	brain expressed associated with NEDD4 1	Gallus gallus	71-75
31374868-7	2019	Over the course of the experiment, animals fed yellow bean diets had significantly (p &lt;= 0.05) higher Hb-Fe than animals fed the white or red kidney bean diet.	Iron	108-110	brain expressed associated with NEDD4 1	Gallus gallus	54-58
31374868-8	2019	This study shows that the Manteca yellow bean possess a rare combination of biochemical traits that result in faster cooking times and improved iron bioavailability.	Iron	144-148	brain expressed associated with NEDD4 1	Gallus gallus	41-45
31171361-2	2019	In the present study, we attempted to investigate the mechanism of iron overload in hepatic fibrosis from the perspective of regulating HSC activation via oxidative stress and miR-374a/Myc axis.	Iron	67-71	microRNA 374a	Homo sapiens	176-184
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	Iron	342-346	microRNA 374a	Homo sapiens	0-8
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	Iron	80-84	microRNA 374a	Homo sapiens	51-59
31667458-3	2019	Clinical data and preclinical models have brought considerable attention to the correlation between iron overload and the development of osteoporosis in HFE/Hfe hemochromatosis.	Iron	100-104	homeostatic iron regulator	Mus musculus	153-156
31229404-2	2019	Here, we describe a mechanism of FBXL5 regulation involving its interaction with the cytosolic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, FAM96B, and CIAO1.	Iron	95-99	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	153-158
31229404-2	2019	Here, we describe a mechanism of FBXL5 regulation involving its interaction with the cytosolic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, FAM96B, and CIAO1.	Iron	95-99	cytosolic iron-sulfur assembly component 1	Homo sapiens	172-177
31331378-1	2019	Ceruloplasmin (Cp) plays an important role in copper transport and iron metabolism, as well as Cp is also an indicator for the health status of dairy cows.	Iron	67-71	ceruloplasmin and hephaestin like 1	Bos taurus	0-13
31241335-5	2019	The data show the typical average Fe-ligand bond length elongation of ~0.18 A for a 5T2 state and suggest a high anisotropy of the primary coordination sphere around the metal center in the excited 5T2 state, in stark contrast to the nearly perfect octahedral symmetry that characterizes the low-spin 1A1 ground state structure.	Iron	34-36	spindlin 1	Homo sapiens	296-300
31354774-0	2019	The Conservation of VIT1-Dependent Iron Distribution in Seeds.	Iron	35-39	vacuolar iron transporter 1	Arabidopsis thaliana	20-24
31354774-9	2019	Furthermore, inside the embryos, Fe accumulated specifically in the endodermal cell layer, a well-known feature that is mediated by VACUOLAR IRON TRANSPORTER1 (VIT1) in model plant Arabidopsis thaliana.	Iron	33-35	vacuolar iron transporter 1	Arabidopsis thaliana	132-158
31354774-9	2019	Furthermore, inside the embryos, Fe accumulated specifically in the endodermal cell layer, a well-known feature that is mediated by VACUOLAR IRON TRANSPORTER1 (VIT1) in model plant Arabidopsis thaliana.	Iron	33-35	vacuolar iron transporter 1	Arabidopsis thaliana	160-164
31354774-10	2019	In rice, Fe enrichment is lost around the provasculature in the mutants of VIT1 orthologs.	Iron	9-11	vacuolar iron transporter 1	Arabidopsis thaliana	75-79
31354774-13	2019	However, it revealed Fe enrichment is widely conserved in the endodermal cell layer in a VIT1-dependent manner in the plant kingdom.	Iron	21-23	vacuolar iron transporter 1	Arabidopsis thaliana	89-93
31354776-2	2019	In Arabidopsis thaliana (Arabidopsis), the root transcriptional response to WCS417 shows significant overlap with the root response to iron (Fe) starvation, including activation of the marker genes MYB72 and IRT1.	Iron	135-139	iron-regulated transporter 1	Arabidopsis thaliana	208-212
31354776-2	2019	In Arabidopsis thaliana (Arabidopsis), the root transcriptional response to WCS417 shows significant overlap with the root response to iron (Fe) starvation, including activation of the marker genes MYB72 and IRT1.	Iron	141-143	iron-regulated transporter 1	Arabidopsis thaliana	208-212
31354776-9	2019	Moreover, the leaf Fe status-dependent shoot-to-root signaling mutant opt3-2, which is impaired in the phloem-specific Fe transporter OPT3, still up-regulated the Fe deficiency response genes MYB72 and IRT1 in response to WCS417.	Iron	19-21	iron-regulated transporter 1	Arabidopsis thaliana	202-206
31291584-3	2019	Acute iron deprivation causes an anti-proliferative Warburg transcriptome, characterized by an ATF4-dependent signature.	Iron	6-10	activating transcription factor 4	Homo sapiens	95-99
30963327-8	2019	The results indicate that Jac1p and Isu1p over-expression in the S. cerevisiae UMArn3.3 yeast increased its ethanol tolerance level and ethanol production by a mechanism that involves ROS and iron homeostasis related to the biogenesis/recycling of Fe-S clusters dependent proteins.	Iron	192-196	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	26-31
30963327-8	2019	The results indicate that Jac1p and Isu1p over-expression in the S. cerevisiae UMArn3.3 yeast increased its ethanol tolerance level and ethanol production by a mechanism that involves ROS and iron homeostasis related to the biogenesis/recycling of Fe-S clusters dependent proteins.	Iron	192-196	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	36-41
30963327-8	2019	The results indicate that Jac1p and Isu1p over-expression in the S. cerevisiae UMArn3.3 yeast increased its ethanol tolerance level and ethanol production by a mechanism that involves ROS and iron homeostasis related to the biogenesis/recycling of Fe-S clusters dependent proteins.	Iron	248-252	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	26-31
30963327-8	2019	The results indicate that Jac1p and Isu1p over-expression in the S. cerevisiae UMArn3.3 yeast increased its ethanol tolerance level and ethanol production by a mechanism that involves ROS and iron homeostasis related to the biogenesis/recycling of Fe-S clusters dependent proteins.	Iron	248-252	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	36-41
30660752-0	2019	Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier.	Iron	49-53	regulating synaptic membrane exocytosis 2	Homo sapiens	27-31
30660752-1	2019	Rim2 is an unusual mitochondrial carrier protein capable of transporting both iron and pyrimidine nucleotides.	Iron	78-82	regulating synaptic membrane exocytosis 2	Homo sapiens	0-4
30660752-3	2019	The Rim2 (E248A) mutant was deficient in mitochondrial iron transport activity.	Iron	55-59	regulating synaptic membrane exocytosis 2	Homo sapiens	4-8
30660752-4	2019	By contrast, the Rim2 (K299A) mutant specifically abrogated pyrimidine nucleotide transport and exchange, while leaving iron transport activity largely unaffected.	Iron	120-124	regulating synaptic membrane exocytosis 2	Homo sapiens	17-21
30660752-9	2019	In mitochondria containing Rim2 (E248A), iron proteins were decreased, including aconitase (Fe-S), pyruvate dehydrogenase (lipoic acid containing) and cytochrome c (heme protein).	Iron	41-45	regulating synaptic membrane exocytosis 2	Homo sapiens	27-31
30660752-11	2019	In summary, mitochondrial iron transport and pyrimidine transport by Rim2 occur separately and independently.	Iron	26-30	regulating synaptic membrane exocytosis 2	Homo sapiens	69-73
30380116-2	2019	We conducted post hoc analyses of a phase 3 trial to explore associations between iron replacement, serum phosphate changes and FGF23 regulation.	Iron	82-86	fibroblast growth factor 23	Homo sapiens	128-133
30767226-2	2019	The iron chelator deferoxamine (DFO) has been widely used to enhance PpIX accumulation by inhibiting the iron-dependent bioconversion of PpIX to heme, a reaction catalyzed by ferrochelatase (FECH).	Iron	4-8	ferrochelatase	Homo sapiens	175-189
30767226-2	2019	The iron chelator deferoxamine (DFO) has been widely used to enhance PpIX accumulation by inhibiting the iron-dependent bioconversion of PpIX to heme, a reaction catalyzed by ferrochelatase (FECH).	Iron	4-8	ferrochelatase	Homo sapiens	191-195
30048196-5	2019	Molecular docking analysis showed that the C2"-position of (2R)-flavanone (3.8 A) was closer to the iron center of CYP2A6 than the C6-position (10 A), while distances from C2" and C6 of (2S)-flavanone to the CYP2A6 were 6.91 A and 5.42 A, respectively.	Iron	100-104	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	115-121
31011744-3	2019	The dysfunction of ATP7B/Atp7b leads to a reduction in the incorporation of copper into apoceruloplasmin; this decreases the ferroxidase activity of ceruloplasmin necessary for the efflux of iron from cells and reduces the release of copper from hepatocytes to the bile; this results in a massive hepatic copper accumulation.	Iron	191-195	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	19-24
31011744-3	2019	The dysfunction of ATP7B/Atp7b leads to a reduction in the incorporation of copper into apoceruloplasmin; this decreases the ferroxidase activity of ceruloplasmin necessary for the efflux of iron from cells and reduces the release of copper from hepatocytes to the bile; this results in a massive hepatic copper accumulation.	Iron	191-195	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	25-30
30974012-0	2019	Unprecedented Five-Coordinate Iron(IV) Imides Generate Divergent Spin States Based on the Imide R-Groups.	Iron	30-34	spindlin 1	Homo sapiens	65-69
30974012-2	2019	These novel structures have disparate spin states on the iron as a function of the R-group attached to the imide, with alkyl groups leading to low-spin diamagnetic (S=0) complexes and an aryl group leading to an intermediate-spin (S=1) complex.	Iron	57-61	spindlin 1	Homo sapiens	38-42
30974012-2	2019	These novel structures have disparate spin states on the iron as a function of the R-group attached to the imide, with alkyl groups leading to low-spin diamagnetic (S=0) complexes and an aryl group leading to an intermediate-spin (S=1) complex.	Iron	57-61	spindlin 1	Homo sapiens	147-151
30974012-2	2019	These novel structures have disparate spin states on the iron as a function of the R-group attached to the imide, with alkyl groups leading to low-spin diamagnetic (S=0) complexes and an aryl group leading to an intermediate-spin (S=1) complex.	Iron	57-61	spindlin 1	Homo sapiens	147-151
30974012-3	2019	The different spin states lead to significant differences in the bonding about the iron center as well as the spectroscopic properties of these complexes.	Iron	83-87	spindlin 1	Homo sapiens	14-18
31231494-7	2019	Both test compounds up-regulated hepcidin and its regulators (BMP-6, SMAD, and TfR2) at the protein and mRNA levels; high dosage treatment may be beneficial, being better than DFO administration in lessening iron deposition in the bone marrow.	Iron	208-212	hepcidin antimicrobial peptide	Mus musculus	33-41
30954544-1	2019	OBJECTIVE: The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism.	Iron	94-98	ferritin heavy polypeptide 1	Mus musculus	15-41
30954544-1	2019	OBJECTIVE: The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism.	Iron	94-98	ferritin heavy polypeptide 1	Mus musculus	43-46
30954544-1	2019	OBJECTIVE: The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism.	Iron	100-102	ferritin heavy polypeptide 1	Mus musculus	15-41
30954544-1	2019	OBJECTIVE: The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism.	Iron	100-102	ferritin heavy polypeptide 1	Mus musculus	43-46
30954544-1	2019	OBJECTIVE: The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism.	Iron	192-194	ferritin heavy polypeptide 1	Mus musculus	15-41
30954544-1	2019	OBJECTIVE: The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism.	Iron	192-194	ferritin heavy polypeptide 1	Mus musculus	43-46
30954544-5	2019	RESULTS: Under standard nutritional Fe supply, Fth deletion in adult FthR26Delta/Delta mice led to a profound deregulation of organismal Fe metabolism, oxidative stress, inflammation, and multi-organ damage, culminating in death.	Iron	36-38	ferritin heavy polypeptide 1	Mus musculus	47-50
30954544-5	2019	RESULTS: Under standard nutritional Fe supply, Fth deletion in adult FthR26Delta/Delta mice led to a profound deregulation of organismal Fe metabolism, oxidative stress, inflammation, and multi-organ damage, culminating in death.	Iron	137-139	ferritin heavy polypeptide 1	Mus musculus	47-50
30954544-8	2019	CONCLUSION: The FTH component of ferritin acts as a master regulator of organismal Fe homeostasis, coupling nutritional Fe supply to organismal redox homeostasis, energy expenditure and thermoregulation.	Iron	83-85	ferritin heavy polypeptide 1	Mus musculus	16-19
30954544-8	2019	CONCLUSION: The FTH component of ferritin acts as a master regulator of organismal Fe homeostasis, coupling nutritional Fe supply to organismal redox homeostasis, energy expenditure and thermoregulation.	Iron	120-122	ferritin heavy polypeptide 1	Mus musculus	16-19
31084334-9	2019	Results- In male mice, CD47 blocking antibody speeded up hematoma/iron clearance by macrophages/microglia and reduced ICH-induced brain swelling, neuronal loss, and neurological deficits.	Iron	66-70	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	23-27
30724105-5	2019	Hepcidin is a master regulator of iron that controls iron-dependent UPEC intracellular growth.	Iron	34-38	hepcidin antimicrobial peptide	Mus musculus	0-8
30724105-5	2019	Hepcidin is a master regulator of iron that controls iron-dependent UPEC intracellular growth.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	0-8
30724105-6	2019	Hepcidin-deficient mice ( Hamp1-/-) exhibit accumulation of iron deposits, persistent bacterial burden in the bladder, and a heightened inflammatory response to UTI.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	0-8
30724105-6	2019	Hepcidin-deficient mice ( Hamp1-/-) exhibit accumulation of iron deposits, persistent bacterial burden in the bladder, and a heightened inflammatory response to UTI.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	26-31
30724105-7	2019	However, a low-iron dietary regimen reversed the iron overload and increased bacterial burden phenotypes in Hamp1-/- mice.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	108-113
30827762-0	2019	The p.H63D allele of the HFE gene protects against low iron stores in Sri Lanka.	Iron	55-59	sorcin	Homo sapiens	70-73
30582749-1	2019	The liver has an important role in iron homeostasis through the synthesis of the serum transporter transferrin and the iron hormone hepcidin.	Iron	35-39	transferrin	Mus musculus	99-110
30582749-1	2019	The liver has an important role in iron homeostasis through the synthesis of the serum transporter transferrin and the iron hormone hepcidin.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	132-140
30582749-1	2019	The liver has an important role in iron homeostasis through the synthesis of the serum transporter transferrin and the iron hormone hepcidin.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	132-140
30797969-6	2019	The results showed that iron could induce pS129 alpha-synuclein (phosphorylation at Ser129) and alpha-synuclein upregulation in the substantia nigra of iron-overloaded rats and iron-treated SH-SY5Y cells, accompanied by the elevated levels of polo-like kinase 2 (PLK2) and casein kinase 2 (CK2).	Iron	24-28	synuclein alpha	Rattus norvegicus	48-63
30797969-6	2019	The results showed that iron could induce pS129 alpha-synuclein (phosphorylation at Ser129) and alpha-synuclein upregulation in the substantia nigra of iron-overloaded rats and iron-treated SH-SY5Y cells, accompanied by the elevated levels of polo-like kinase 2 (PLK2) and casein kinase 2 (CK2).	Iron	24-28	synuclein alpha	Rattus norvegicus	96-111
30797969-6	2019	The results showed that iron could induce pS129 alpha-synuclein (phosphorylation at Ser129) and alpha-synuclein upregulation in the substantia nigra of iron-overloaded rats and iron-treated SH-SY5Y cells, accompanied by the elevated levels of polo-like kinase 2 (PLK2) and casein kinase 2 (CK2).	Iron	152-156	synuclein alpha	Rattus norvegicus	96-111
30797969-6	2019	The results showed that iron could induce pS129 alpha-synuclein (phosphorylation at Ser129) and alpha-synuclein upregulation in the substantia nigra of iron-overloaded rats and iron-treated SH-SY5Y cells, accompanied by the elevated levels of polo-like kinase 2 (PLK2) and casein kinase 2 (CK2).	Iron	152-156	synuclein alpha	Rattus norvegicus	96-111
31040364-0	2019	Targeting GPER1 to suppress autophagy as a male-specific therapeutic strategy for iron-induced striatal injury.	Iron	82-86	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
31040364-8	2019	This finding opens the prospect of a male-specific therapeutic strategy targeting GPER1 for autophagy suppression in patients suffering from iron overload after hemorrhage.	Iron	141-145	G protein-coupled estrogen receptor 1	Homo sapiens	82-87
31459865-0	2019	High-Tap-Density Fe-Doped Nickel Hydroxide with Enhanced Lithium Storage Performance.	Iron	17-19	nuclear RNA export factor 1	Homo sapiens	5-8
31459865-3	2019	Herein, Fe-doped nickel hydroxide powders with a high tap density (2.16 g cm-3) are synthesized by a simple chemical co-precipitation method.	Iron	8-10	nuclear RNA export factor 1	Homo sapiens	54-57
30879301-4	2019	UV-vis, EPR, and Mossbauer spectroscopy of purified wild-type Apd1 and three His to Cys variants demonstrated that Cys207 and Cys216 are the ligands of the ferric ion, and His255 and His259 are the ligands of the reducible iron ion of the [2Fe-2S]2+/1+ cluster.	Iron	223-227	Apd1p	Saccharomyces cerevisiae S288C	62-66
30883126-3	2019	Here we report on the investigation of "frozen" metallic centers in nanoparticles (2-80 nm size) of the spin-crossover compound Fe(pyrazine)[Ni(CN)4].	Iron	128-130	spindlin 1	Homo sapiens	104-108
31001291-4	2019	We observed that the altered expression of miR408 diminished plant performance and the activation of the iron-regulated genes under iron-deficient conditions.	Iron	105-109	MIR408	Arabidopsis thaliana	43-49
31001291-4	2019	We observed that the altered expression of miR408 diminished plant performance and the activation of the iron-regulated genes under iron-deficient conditions.	Iron	132-136	MIR408	Arabidopsis thaliana	43-49
31001291-8	2019	Taken together, these results suggest that Arabidopsis plants with modified miR408 levels undergo multiple deregulations under iron-deficient conditions.	Iron	127-131	MIR408	Arabidopsis thaliana	76-82
30506348-8	2019	It was noted that individuals homozygous or heterozygous for the effect allele in the BCL11A and HMIP SNPs had higher HbF levels, lower ferritin concentrations, and lower liver iron content and were less likely to be transfusion dependent.	Iron	177-181	mitochondrial intermediate peptidase	Homo sapiens	97-101
30599084-3	2019	We found that the intracellular depletion of iron leads to a rapid downregulation of NANOG and a dramatic decrease in the self-renewal of hPSCs as well as spontaneous and nonspecific differentiation.	Iron	45-49	Nanog homeobox	Homo sapiens	85-90
30599084-5	2019	Additionally, we found that the depletion of iron increased the activity of lipoprotein-associated phospholipase A2 (LP-PLA2) and the production of lysophosphatidylcholine, thereby suppressing NANOG expression by enhancer of zeste homolog 2-mediated trimethylation of histone H3 lysine 27.	Iron	45-49	phospholipase A2 group VII	Homo sapiens	76-115
30599084-5	2019	Additionally, we found that the depletion of iron increased the activity of lipoprotein-associated phospholipase A2 (LP-PLA2) and the production of lysophosphatidylcholine, thereby suppressing NANOG expression by enhancer of zeste homolog 2-mediated trimethylation of histone H3 lysine 27.	Iron	45-49	phospholipase A2 group VII	Homo sapiens	117-124
30599084-5	2019	Additionally, we found that the depletion of iron increased the activity of lipoprotein-associated phospholipase A2 (LP-PLA2) and the production of lysophosphatidylcholine, thereby suppressing NANOG expression by enhancer of zeste homolog 2-mediated trimethylation of histone H3 lysine 27.	Iron	45-49	Nanog homeobox	Homo sapiens	193-198
30599084-6	2019	Consistently, LP-PLA2 inhibition abrogated iron depletion-induced loss of pluripotency and differentiation.	Iron	43-47	phospholipase A2 group VII	Homo sapiens	14-21
30785184-7	2019	Overall, unlike their eukaryotic and prokaryotic counterparts, which are specific to [Fe4S4] proteins, NFU2 and NFU3 contribute to the maturation of both [Fe2S2] and [Fe4S4] proteins, either as a relay in conjunction with other proteins such as HCF101 or by directly delivering Fe-S clusters to client proteins.	Iron	278-282	NIFU-like protein 2	Arabidopsis thaliana	103-107
30785184-7	2019	Overall, unlike their eukaryotic and prokaryotic counterparts, which are specific to [Fe4S4] proteins, NFU2 and NFU3 contribute to the maturation of both [Fe2S2] and [Fe4S4] proteins, either as a relay in conjunction with other proteins such as HCF101 or by directly delivering Fe-S clusters to client proteins.	Iron	278-282	NFU domain protein 3	Arabidopsis thaliana	112-116
30586758-0	2019	Iron Regulator Hepcidin Impairs Macrophage-Dependent Cardiac Repair After Injury.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	15-23
30586758-2	2019	Hepcidin, a master iron sensor, actively tunes iron trafficking.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	0-8
30586758-2	2019	Hepcidin, a master iron sensor, actively tunes iron trafficking.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	0-8
30647129-1	2019	Iron efflux from mammalian cells is supported by the synergistic actions of the ferrous iron efflux transporter, ferroportin (Fpn) and a multicopper ferroxidase, that is, hephaestin (Heph), ceruloplasmin (Cp) or both.	Iron	0-4	hephaestin	Homo sapiens	183-187
30647129-6	2019	We demonstrate that Fpn and Heph co-localize, and FRET analysis indicated that the two proteins form an iron-efflux complex.	Iron	104-108	hephaestin	Homo sapiens	28-32
30713087-5	2019	Further, when Dmt1int/int mice were crossed with mice lacking the iron-regulatory hormone, hepcidin (Hepc-/-), iron loading was abolished.	Iron	66-70	hepcidin antimicrobial peptide	Mus musculus	91-99
30685084-3	2019	We found that Irp2-/- mice exhibited hyperglycemia and iron overload in the liver and skeletal muscle.	Iron	55-59	iron responsive element binding protein 2	Mus musculus	14-18
30832301-7	2019	Adding 5 mg L-1 Fe or Mg ions increased AFG1 production even without activated carbon.	Iron	16-18	AFG1 like ATPase	Homo sapiens	40-44
31218207-4	2019	Unexpectedly, studies of common and rare heritable disorders of phosphate handling identified links between iron and FGF23 demonstrating novel regulation outside the phosphate pathway.	Iron	108-112	fibroblast growth factor 23	Homo sapiens	117-122
31218207-7	2019	Additionally, specific iron formulations, used to treat iron deficiency, alter post-translational processing thereby shifting FGF23 protein secretion.	Iron	23-27	fibroblast growth factor 23	Homo sapiens	126-131
31218207-9	2019	This review will focus upon the novel discoveries elucidated between iron, its regulators, and their influence on FGF23 bioactivity.	Iron	69-73	fibroblast growth factor 23	Homo sapiens	114-119
30570704-0	2019	Regulation of mitochondrial iron homeostasis by sideroflexin 2.	Iron	28-32	sideroflexin 2	Homo sapiens	48-62
30570704-4	2019	Here, we show that human sideroflexin 2 (SFXN2), a member of the SFXN protein family, is involved in mitochondrial iron metabolism.	Iron	115-119	sideroflexin 2	Homo sapiens	25-39
30570704-4	2019	Here, we show that human sideroflexin 2 (SFXN2), a member of the SFXN protein family, is involved in mitochondrial iron metabolism.	Iron	115-119	sideroflexin 2	Homo sapiens	41-46
30570704-6	2019	SFXN2-knockout (KO) cells had an increased mitochondrial iron content, which was associated with decreases in the heme content and heme-dependent enzyme activities.	Iron	57-61	sideroflexin 2	Homo sapiens	0-5
30570704-8	2019	Moreover, abnormal iron metabolism impaired mitochondrial respiration in SFXN2-KO cells and accelerated iron-mediated death of these cells.	Iron	19-23	sideroflexin 2	Homo sapiens	73-78
30570704-9	2019	Our findings demonstrate that SFXN2 functions in mitochondrial iron metabolism by regulating heme biosynthesis.	Iron	63-67	sideroflexin 2	Homo sapiens	30-35
30553949-6	2019	On light exposure, the combined hydroxypyridinone iron chelating ALA prodrug AP2-18 generated significantly greater cytotoxicity than any of the other treatment parameters investigated when the lowest concentration (250 muM) was employed.	Iron	50-54	transcription factor AP-2 alpha	Homo sapiens	77-80
30609600-1	2019	Hemoglobin-containing electrochemical biosensors are useful for detecting hydrogen peroxide through oxidation of the iron ion, but high efficiency can only be reached with appropriate immobilization strategies for hemoglobin.	Iron	117-121	non-symbiotic hemoglobin	Zea mays	0-10
30873034-6	2019	Meanwhile, we found that iron overload induced by 100 muM FAC significantly inhibited mitochondrial fission protein FIS1 and fusion protein MFN2 expressions, inhibited DRP1 and Cytochrome C protein translocation from the cytoplasm to mitochondria.	Iron	25-29	fission, mitochondrial 1	Homo sapiens	116-120
30873034-6	2019	Meanwhile, we found that iron overload induced by 100 muM FAC significantly inhibited mitochondrial fission protein FIS1 and fusion protein MFN2 expressions, inhibited DRP1 and Cytochrome C protein translocation from the cytoplasm to mitochondria.	Iron	25-29	mitofusin 2	Homo sapiens	140-144
30873154-5	2019	FTH downregulation, either by shRNA transfection or iron chelation, led to MHC surface reduction in primary cancer cells and macrophages.	Iron	52-56	ferritin heavy polypeptide 1	Mus musculus	0-3
30873154-7	2019	Low iron concentration, but not FTH, interfered with IFN-gamma receptor signaling, preventing the increase of MHC-class I molecules on the membrane by obstructing STAT1 phosphorylation and nuclear translocation.	Iron	4-8	signal transducer and activator of transcription 1	Mus musculus	163-168
30777083-9	2019	NOX2 and NOX4 inhibition significantly reduced ROS production among microglia exposed to iron and LPS and reduced neuronal damage and death in response to microglial co-culture.	Iron	89-93	cytochrome b-245 beta chain	Homo sapiens	0-4
30777083-11	2019	Further, this study highlights both NOX2 and NOX4 as potential therapeutic targets in the treatment of iron-induced microglia-related inflammation and neurotoxicity.	Iron	103-107	cytochrome b-245 beta chain	Homo sapiens	36-40
30521948-2	2019	Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases.	Iron	0-4	RoBo-1	Rattus norvegicus	56-60
29989313-0	2019	The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis.	Iron	59-63	Homeodomain-like superfamily protein	Arabidopsis thaliana	46-49
29989313-3	2019	Here, we show that, in Arabidopsis thaliana, loss of the central clock genes, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), results in both reduced Fe uptake and photosynthetic efficiency, whereas CCA1 overexpression confers the opposite effects.	Iron	174-176	Homeodomain-like superfamily protein	Arabidopsis thaliana	118-142
29989313-6	2019	Thus, this study established that, in plants, CCA1 and LHY function as master regulators that maintain cyclic Fe homeostasis.	Iron	110-112	Homeodomain-like superfamily protein	Arabidopsis thaliana	55-58
30766541-6	2019	Here, we report two small-molecules, R3 and R6 [where R denotes repressor of IRON-REGULATED TRANSPORTER 1 (IRT1)], identified through a chemical screening, whose use blocked activation of the Fe-deficiency response in Arabidopsis thaliana.	Iron	192-194	iron-regulated transporter 1	Arabidopsis thaliana	77-105
30766541-6	2019	Here, we report two small-molecules, R3 and R6 [where R denotes repressor of IRON-REGULATED TRANSPORTER 1 (IRT1)], identified through a chemical screening, whose use blocked activation of the Fe-deficiency response in Arabidopsis thaliana.	Iron	192-194	iron-regulated transporter 1	Arabidopsis thaliana	107-111
30766541-10	2019	Small-molecule treatments attenuated the Fe-deficiency-induced expression of the Fe uptake gene IRT1.	Iron	41-43	iron-regulated transporter 1	Arabidopsis thaliana	96-100
30766541-10	2019	Small-molecule treatments attenuated the Fe-deficiency-induced expression of the Fe uptake gene IRT1.	Iron	81-83	iron-regulated transporter 1	Arabidopsis thaliana	96-100
30538134-0	2019	Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.	Iron	41-45	hepcidin antimicrobial peptide	Mus musculus	73-81
30538134-0	2019	Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.	Iron	111-115	hepcidin antimicrobial peptide	Mus musculus	73-81
30538134-1	2019	Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types.	Iron	79-83	transferrin	Mus musculus	61-72
30538134-5	2019	Nevertheless, their liver iron content (LIC) is lower compared with that of control Tfrcfl/fl littermates as a result of the reduced capacity of Tfr1-deficient hepatocytes to internalize iron from transferrin.	Iron	187-191	transferrin	Mus musculus	197-208
30538134-8	2019	TfrcAlb-Cre mice appropriately regulate Hamp expression following dietary iron manipulations or holo-transferrin injection.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	40-44
30538134-11	2019	We conclude that Tfr1 is redundant for basal hepatocellular iron supply but essential for fine-tuning hepcidin responses according to the iron load of hepatocytes.	Iron	138-142	hepcidin antimicrobial peptide	Mus musculus	102-110
30538134-12	2019	Our data are consistent with an inhibitory function of Tfr1 on iron signaling to hepcidin via its interaction with Hfe.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	81-89
30538134-12	2019	Our data are consistent with an inhibitory function of Tfr1 on iron signaling to hepcidin via its interaction with Hfe.	Iron	63-67	homeostatic iron regulator	Mus musculus	115-118
30458168-3	2019	Suboptimal erythropoiesis in chronic inflammation is believed to be caused by elevated hepcidin levels, which causes blockade of iron in tissue stores.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	87-95
33405867-4	2019	We utilized a sepia-melanin, squid ink, derived NM analogue (NM-sim) to chelate ferric iron, and this iron-neuromelanin precipitate (Fe-NM) was purified and characterized.	Iron	133-135	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	48-50
33405867-4	2019	We utilized a sepia-melanin, squid ink, derived NM analogue (NM-sim) to chelate ferric iron, and this iron-neuromelanin precipitate (Fe-NM) was purified and characterized.	Iron	133-135	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	61-63
33405867-4	2019	We utilized a sepia-melanin, squid ink, derived NM analogue (NM-sim) to chelate ferric iron, and this iron-neuromelanin precipitate (Fe-NM) was purified and characterized.	Iron	133-135	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	107-119
33405867-4	2019	We utilized a sepia-melanin, squid ink, derived NM analogue (NM-sim) to chelate ferric iron, and this iron-neuromelanin precipitate (Fe-NM) was purified and characterized.	Iron	133-135	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	61-63
30425102-6	2019	Whereas fadrozole binds to both CYP11B enzymes by coordinating the heme iron, CYP11B2 binds to the R enantiomer of fadrozole, and CYP11B1 binds to the S enantiomer, each with distinct orientations and interactions.	Iron	72-76	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	32-38
31229168-5	2019	Studies on the impact of sex, MEIS1 (associated with RLS), and H63D gene variants have revealed critical regulatory mechanisms and driving factors that significantly impact iron transport that may considerably affect the clinical treatment of RLS.	Iron	173-177	Meis homeobox 1	Homo sapiens	30-35
30191282-8	2019	Compared to wild-type mice, Irp2-/- mice exhibited reduced BMD, bone iron deficiency, and hepatic iron overload.	Iron	69-73	iron responsive element binding protein 2	Mus musculus	28-32
30191282-14	2019	Irp2-/- mice exhibit reduced bone iron content and osteoporosis.	Iron	34-38	iron responsive element binding protein 2	Mus musculus	0-4
30448512-4	2019	Knowing that the Abeta42 peptide precipitates iron by binding iron ions at amino acid residues D1, E3, H11, H13, and H14, we synthesized a 5-repeat (HAYED) sequence peptide.	Iron	46-50	H1.4 linker histone, cluster member	Mus musculus	117-120
30232784-7	2019	These results suggest that, in BM, the decrease in TfR, which may be associated with increased MafB levels, and the decrease in erythroferrone increase hepatic hepcidin expression, which may perturb iron recycling and erythropoiesis.	Iron	199-203	hepcidin antimicrobial peptide	Mus musculus	160-168
30994016-0	2019	Potential role of MRN-100, an iron-based compound, in upregulating production of cytokine IL-10 in human dendritic cells to promote an anti-inflammatory response in vitro.	Iron	30-34	interleukin 10	Homo sapiens	90-95
30745811-6	2019	Those with iron overload had higher EPO, GDF15, SF and sTfR levels compared with non-iron overload patients.	Iron	11-15	growth differentiation factor 15	Homo sapiens	41-46
30605903-7	2019	To safeguard against iron thievery, the host relies upon the innate immune protein, lipocalin 2 (Lcn2), which could sequester catecholate-type siderophores and thus impede bacterial growth.	Iron	21-25	lipocalin 2	Homo sapiens	84-95
30605903-7	2019	To safeguard against iron thievery, the host relies upon the innate immune protein, lipocalin 2 (Lcn2), which could sequester catecholate-type siderophores and thus impede bacterial growth.	Iron	21-25	lipocalin 2	Homo sapiens	97-101
30652531-7	2019	Our results showed that FeD produced a significant reduction in MBP and PMP22 content at P29, which persisted at P60 after Fe-sufficient diet replenishment regardless of Mn exposure levels.	Iron	24-26	myelin basic protein	Rattus norvegicus	64-67
30652531-7	2019	Our results showed that FeD produced a significant reduction in MBP and PMP22 content at P29, which persisted at P60 after Fe-sufficient diet replenishment regardless of Mn exposure levels.	Iron	24-26	peripheral myelin protein 22	Rattus norvegicus	72-77
30655769-8	2019	The iron content and expression levels of SF, FTH and FTL were increased in HNSCC with metastasis compared with HNSCC without metastasis.	Iron	4-8	ferritin light chain	Homo sapiens	54-57
29734523-6	2019	Iron and zinc were increased close to recommended levels in polished grains of the transformed lines, with maximum levels when AtNRAMP3, AtNAS1 and PvFER were expressed together (12.67 mug/g DW iron and 45.60 mug/g DW zinc in polished grains of line NFON16).	Iron	0-4	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	127-135
30551574-0	2018	Iron Biofortified Carioca Bean (Phaseolus vulgaris L.)-Based Brazilian Diet Delivers More Absorbable Iron and Affects the Gut Microbiota In Vivo (Gallus gallus).	Iron	0-4	brain expressed associated with NEDD4 1	Gallus gallus	26-30
30551574-0	2018	Iron Biofortified Carioca Bean (Phaseolus vulgaris L.)-Based Brazilian Diet Delivers More Absorbable Iron and Affects the Gut Microbiota In Vivo (Gallus gallus).	Iron	101-105	brain expressed associated with NEDD4 1	Gallus gallus	26-30
30551574-3	2018	In this study, we performed a 6-week feeding trial in Gallus gallus (n = 15), aimed to investigate the Fe status and the alterations in the gut microbiome following the administration of Fe-biofortified carioca bean based diet (BC) versus a Fe-standard carioca bean based diet (SC).	Iron	187-189	brain expressed associated with NEDD4 1	Gallus gallus	211-215
30551574-3	2018	In this study, we performed a 6-week feeding trial in Gallus gallus (n = 15), aimed to investigate the Fe status and the alterations in the gut microbiome following the administration of Fe-biofortified carioca bean based diet (BC) versus a Fe-standard carioca bean based diet (SC).	Iron	187-189	brain expressed associated with NEDD4 1	Gallus gallus	261-265
30551574-3	2018	In this study, we performed a 6-week feeding trial in Gallus gallus (n = 15), aimed to investigate the Fe status and the alterations in the gut microbiome following the administration of Fe-biofortified carioca bean based diet (BC) versus a Fe-standard carioca bean based diet (SC).	Iron	187-189	brain expressed associated with NEDD4 1	Gallus gallus	211-215
30551574-3	2018	In this study, we performed a 6-week feeding trial in Gallus gallus (n = 15), aimed to investigate the Fe status and the alterations in the gut microbiome following the administration of Fe-biofortified carioca bean based diet (BC) versus a Fe-standard carioca bean based diet (SC).	Iron	187-189	brain expressed associated with NEDD4 1	Gallus gallus	261-265
30551574-5	2018	Two primary outcomes were observed: (1) a significant increase in total body Hb-Fe values in the group receiving the Fe-biofortified carioca bean based diet; and (2) changes in the gut microbiome composition and function were observed, specifically, significant changes in phylogenetic diversity between treatment groups, as there was increased abundance of bacteria linked to phenolic catabolism, and increased abundance of beneficial SCFA-producing bacteria in the BC group.	Iron	117-119	brain expressed associated with NEDD4 1	Gallus gallus	141-145
30551574-7	2018	Our results demonstrate that the Fe-biofortified carioca bean variety was able to moderately improve Fe status and to positively affect the intestinal functionality and bacterial populations.	Iron	33-35	brain expressed associated with NEDD4 1	Gallus gallus	57-61
30551574-7	2018	Our results demonstrate that the Fe-biofortified carioca bean variety was able to moderately improve Fe status and to positively affect the intestinal functionality and bacterial populations.	Iron	101-103	brain expressed associated with NEDD4 1	Gallus gallus	57-61
30403845-13	2018	The large spin ground states, indicative of strong ferromagnetic electronic alignment of the valence electrons, result from strong direct exchange electronic coupling mediated by Fe-Fe orbital overlap within the [Fe6] cores, equivalent to a strong double exchange magnetic coupling B for 3 that was calculated to be 309 cm-1.	Iron	179-181	spindlin 1	Homo sapiens	10-14
30403845-13	2018	The large spin ground states, indicative of strong ferromagnetic electronic alignment of the valence electrons, result from strong direct exchange electronic coupling mediated by Fe-Fe orbital overlap within the [Fe6] cores, equivalent to a strong double exchange magnetic coupling B for 3 that was calculated to be 309 cm-1.	Iron	182-184	spindlin 1	Homo sapiens	10-14
30227271-4	2018	Iron overload in mice with hepatocyte-specific Alk2 and Alk3 (Alk2/3) deficiency was characterized and compared to hepatocyte-specific Alk3 deficient mice.	Iron	0-4	activin A receptor, type 1	Mus musculus	47-51
30227271-4	2018	Iron overload in mice with hepatocyte-specific Alk2 and Alk3 (Alk2/3) deficiency was characterized and compared to hepatocyte-specific Alk3 deficient mice.	Iron	0-4	bone morphogenetic protein receptor, type 1A	Mus musculus	56-60
30227271-4	2018	Iron overload in mice with hepatocyte-specific Alk2 and Alk3 (Alk2/3) deficiency was characterized and compared to hepatocyte-specific Alk3 deficient mice.	Iron	0-4	bone morphogenetic protein receptor, type 1A	Mus musculus	62-68
30227271-6	2018	The iron overload phenotype of hepatocyte-specific Alk2/3-deficient mice was more severe than that of hepatocyte-specific Alk3-deficient mice.	Iron	4-8	bone morphogenetic protein receptor, type 1A	Mus musculus	51-57
30227271-11	2018	Our data indicate that: (I) ALK2 and ALK3 have additive functions in vivo, as Alk2/3 deficiency leads to a greater degree of iron overload than Alk3 deficiency; (II) ALK3, but not ALK2, undergoes ligand-independent homodimerization; (III) the formation of ALK2-ALK3 heterodimers is ligand-dependent and (IV) both receptor complexes functionally induce hepcidin expression in vitro.	Iron	125-129	activin A receptor, type 1	Mus musculus	28-32
30227271-11	2018	Our data indicate that: (I) ALK2 and ALK3 have additive functions in vivo, as Alk2/3 deficiency leads to a greater degree of iron overload than Alk3 deficiency; (II) ALK3, but not ALK2, undergoes ligand-independent homodimerization; (III) the formation of ALK2-ALK3 heterodimers is ligand-dependent and (IV) both receptor complexes functionally induce hepcidin expression in vitro.	Iron	125-129	bone morphogenetic protein receptor, type 1A	Mus musculus	37-41
30227271-11	2018	Our data indicate that: (I) ALK2 and ALK3 have additive functions in vivo, as Alk2/3 deficiency leads to a greater degree of iron overload than Alk3 deficiency; (II) ALK3, but not ALK2, undergoes ligand-independent homodimerization; (III) the formation of ALK2-ALK3 heterodimers is ligand-dependent and (IV) both receptor complexes functionally induce hepcidin expression in vitro.	Iron	125-129	bone morphogenetic protein receptor, type 1A	Mus musculus	78-84
30675115-1	2018	Ovotransferrin (OTF) is a well-known protein of the transferrin family with strong iron chelating activity, resulting in its antimicrobial activity.	Iron	83-87	transferrin	Mus musculus	3-14
30118955-2	2018	The removal performance of Fe0/Cu0 bimetallic composites for DC13 in terms of Fe/Cu ratios, addition amount, reaction time and initial pH were studied.	Iron	27-29	C-X9-C motif containing 2	Homo sapiens	61-65
30217414-1	2018	Hepcidin has emerged as the central regulatory molecule in systemic iron homeostasis.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
29923765-5	2018	The systemic iron redistribution was aggravated, resulting in anemia and the marked downregulation of hepatic hepcidin in elderly FPN knockout (KO)/Nestin-Cre mice.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	110-118
29903760-2	2018	As this molecule influences the production of the iron regulatory hormone hepcidin, we hypothesized that erythropoiesis-driven changes in diferric transferrin levels could contribute to the decrease in hepcidin observed following the administration of erythropoietin.	Iron	50-54	hepcidin antimicrobial peptide	Mus musculus	74-82
29903760-2	2018	As this molecule influences the production of the iron regulatory hormone hepcidin, we hypothesized that erythropoiesis-driven changes in diferric transferrin levels could contribute to the decrease in hepcidin observed following the administration of erythropoietin.	Iron	50-54	transferrin	Mus musculus	147-158
29903760-7	2018	Increasing diferric transferrin levels via intravenous iron injection prevented the inhibition of Hamp1 expression by erythropoietin without altering hepatic iron concentration or the expression of Erfe, the gene encoding erythroferrone.	Iron	55-59	transferrin	Mus musculus	20-31
29903760-7	2018	Increasing diferric transferrin levels via intravenous iron injection prevented the inhibition of Hamp1 expression by erythropoietin without altering hepatic iron concentration or the expression of Erfe, the gene encoding erythroferrone.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	98-103
31729346-1	2018	Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor.	Iron	102-106	vitamin D receptor	Homo sapiens	166-184
31729346-1	2018	Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor.	Iron	102-106	vitamin D receptor	Homo sapiens	186-189
29878379-1	2018	BRUTUS (BTS) is an iron binding E3 ligase that has been shown to bind to and influence the accumulation of target basic helix-loop-helix transcription factors through 26S proteasome-mediated degradation in Arabidopsis thaliana.	Iron	19-23	zinc finger protein-like protein	Arabidopsis thaliana	0-6
29878379-1	2018	BRUTUS (BTS) is an iron binding E3 ligase that has been shown to bind to and influence the accumulation of target basic helix-loop-helix transcription factors through 26S proteasome-mediated degradation in Arabidopsis thaliana.	Iron	19-23	zinc finger protein-like protein	Arabidopsis thaliana	8-11
30091524-6	2018	Finally, a cell penetration study using the radio-labeled antitumor agent gemcitabine monophosphate (3 H-GMP)-loaded MIL-100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness.	Iron	125-127	5'-nucleotidase, cytosolic II	Homo sapiens	105-108
29990562-8	2018	The NADPH oxidase subunit gp91phox was increased due to iron-overload, and incubation with angiotensin II type-1 receptor (AT1) antagonist losartan not only reduced oxidative stress but also restored vascular function.	Iron	56-60	cytochrome b-245 beta chain	Rattus norvegicus	26-34
30204426-3	2018	In vitro studies using apo-ferredoxin (FDX) reveal that mNT uses an Fe-based redox switch mechanism to regulate the transfer of its cluster.	Iron	68-70	ferredoxin 1	Homo sapiens	39-42
30250199-10	2018	These findings suggest a new mechanism of cellular iron dysfunction through the E4BP4/G9a/SOSTDC1/hepcidin pathway, which is an essential link in TC.	Iron	51-55	euchromatic histone lysine methyltransferase 2	Homo sapiens	86-89
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	36-40	collapsin response mediator protein 1	Mus musculus	310-314
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	187-191	collapsin response mediator protein 1	Mus musculus	310-314
29906559-4	2018	In this study, we demonstrated that iron overload induces ROS production earlier in the ER than in the mitochondria, and peroxiredoxin 5 (Prx5), which is a kind of antioxidant induced by iron overload, prevents iron overload-induced mitochondrial fragmentation mediated by contact with ER and translocation of Drp1, by inhibiting ROS production and calcium/calcineurin pathway in HT-22 mouse hippocampal neuronal cells.	Iron	187-191	collapsin response mediator protein 1	Mus musculus	310-314
29600572-0	2018	Adenine alleviates iron overload by cAMP/PKA mediated hepatic hepcidin in mice.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	62-70
29600572-3	2018	Our unbiased vitamin screen for modulators of hepcidin, a master iron regulatory hormone, identifies adenine (vitamin B4) as a potent hepcidin agonist.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	46-54
30105122-1	2018	Iron-sulfur cluster assembly 1 (ISCA1) is one of the essential proteins operating in the mitochondrial iron-sulfur (Fe-S) cluster biogenesis pathway.	Iron	116-120	iron-sulfur cluster assembly 1	Homo sapiens	0-30
30105122-1	2018	Iron-sulfur cluster assembly 1 (ISCA1) is one of the essential proteins operating in the mitochondrial iron-sulfur (Fe-S) cluster biogenesis pathway.	Iron	116-120	iron-sulfur cluster assembly 1	Homo sapiens	32-37
30230853-1	2018	We compute the thermal conductivity and electrical resistivity of solid hcp Fe to pressures and temperatures of Earth"s core.	Iron	76-78	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	72-75
29800736-9	2018	Notably, the enhanced expression of TOR1 and TOR2 rescue the Torin2 augmented iron toxicity of yeast cell.	Iron	78-82	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	36-40
30079725-2	2018	Until now, epitaxial yttrium iron garnet (YIG) films grown on gadolinium gallium garnet (GGG) substrates by a pulsed laser deposition have been most widely used for spin thermoelectric energy conversion studies.	Iron	29-33	spindlin 1	Homo sapiens	165-169
30186827-4	2018	The main structural modifications, when passing from the low-spin to the high-spin form, consist of an important lengthening of the Fe-N(Mebik) and Fe-N (C-S/Se) distances (by ca.	Iron	132-136	spindlin 1	Homo sapiens	61-65
30186827-4	2018	The main structural modifications, when passing from the low-spin to the high-spin form, consist of an important lengthening of the Fe-N(Mebik) and Fe-N (C-S/Se) distances (by ca.	Iron	132-136	spindlin 1	Homo sapiens	78-82
30186827-4	2018	The main structural modifications, when passing from the low-spin to the high-spin form, consist of an important lengthening of the Fe-N(Mebik) and Fe-N (C-S/Se) distances (by ca.	Iron	148-152	spindlin 1	Homo sapiens	61-65
30186827-4	2018	The main structural modifications, when passing from the low-spin to the high-spin form, consist of an important lengthening of the Fe-N(Mebik) and Fe-N (C-S/Se) distances (by ca.	Iron	148-152	spindlin 1	Homo sapiens	78-82
30100261-0	2018	PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism.	Iron	83-87	parkin RBR E3 ubiquitin protein ligase	Mus musculus	10-15
30100261-2	2018	Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism.	Iron	111-115	parkin RBR E3 ubiquitin protein ligase	Mus musculus	36-41
30100261-4	2018	PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, which leads to the HIF1A-dependent Warburg effect and AIM2-dependent inflammasome activation in tumor cells.	Iron	90-94	parkin RBR E3 ubiquitin protein ligase	Mus musculus	6-11
30272000-1	2018	Dietary iron absorption is regulated by duodenal cytochrome b (Dcytb), an integral membrane protein that catalyzes reduction of nonheme Fe3+ by electron transfer from ascorbate across the membrane.	Iron	8-12	cytochrome b reductase 1	Homo sapiens	40-61
30272000-1	2018	Dietary iron absorption is regulated by duodenal cytochrome b (Dcytb), an integral membrane protein that catalyzes reduction of nonheme Fe3+ by electron transfer from ascorbate across the membrane.	Iron	8-12	cytochrome b reductase 1	Homo sapiens	63-68
29995418-5	2018	The increased amounts of therapeutic growth factors inside NV-IONP were attributed to IONPs that are slowly ionized to iron ions which activate the JNK and c-Jun signaling cascades in hMSCs.	Iron	119-123	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-161
29684424-0	2018	Drosophila multicopper oxidase 3 is a potential ferroxidase involved in iron homeostasis.	Iron	72-76	Multicopper oxidase 3	Drosophila melanogaster	11-32
29684424-10	2018	A null dMCO3 mutant, generated by CRISPR/Cas9 technology, showed disrupted iron homeostasis, evidenced by increased iron level and reduced metal importer Mvl expression.	Iron	75-79	Multicopper oxidase 3	Drosophila melanogaster	7-12
29684424-10	2018	A null dMCO3 mutant, generated by CRISPR/Cas9 technology, showed disrupted iron homeostasis, evidenced by increased iron level and reduced metal importer Mvl expression.	Iron	116-120	Multicopper oxidase 3	Drosophila melanogaster	7-12
29684424-11	2018	Notably, dMCO3-null flies phenotypically are largely normal at normal or iron stressed-conditions.	Iron	73-77	Multicopper oxidase 3	Drosophila melanogaster	9-14
29684424-13	2018	However, its importance to fly iron homeostasis is greatly minimized, which is instead dominated by another iron efflux avenue mediated by the ZIP13-ferritin axis along the ER/Golgi secretion pathway.	Iron	31-35	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	143-148
29684424-13	2018	However, its importance to fly iron homeostasis is greatly minimized, which is instead dominated by another iron efflux avenue mediated by the ZIP13-ferritin axis along the ER/Golgi secretion pathway.	Iron	108-112	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	143-148
29730778-2	2018	Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism.	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	0-8
29730778-2	2018	Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism.	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	10-13
29730778-2	2018	Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism.	Iron	189-193	hepcidin antimicrobial peptide	Mus musculus	0-8
29730778-2	2018	Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism.	Iron	189-193	hepcidin antimicrobial peptide	Mus musculus	10-13
29730778-8	2018	Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes.	Iron	48-50	hepcidin antimicrobial peptide	Mus musculus	231-234
29732486-12	2018	Duodenal iron content was also lower in Atp7b(-/-) mice, but did not reach statistical significance.	Iron	9-13	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	40-45
29181658-4	2018	We hypothesized that ferric citrate hydrate, an iron-based phosphate binder, will decrease serum FGF23 levels in patients with non-dialysis-dependent CKD with normophosphatemia and iron deficiency.	Iron	48-52	fibroblast growth factor 23	Homo sapiens	97-102
29853274-2	2018	FA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters.	Iron	130-134	frataxin	Mus musculus	0-2
29853274-2	2018	FA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters.	Iron	130-134	frataxin	Mus musculus	34-42
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	39-43	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	203-208
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	203-208
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	203-208
29995317-3	2018	In the yeast Saccharomyces cerevisiae, iron homeostasis is maintained by the transcriptional control of the iron acquisition systems (iron regulon), mainly by the iron-responsive transcriptional factors Aft1p and Yap5p.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	203-208
29995317-8	2018	Hog1p, a MAP kinase involved in stress responses, also negatively regulates iron uptake by phosphorylating Aft1p.	Iron	76-80	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	107-112
29752522-0	2018	Meta-QTL analysis of seed iron and zinc concentration and content in common bean (Phaseolus vulgaris L.).	Iron	26-30	brain expressed associated with NEDD4 1	Homo sapiens	76-80
29752522-3	2018	Common bean (Phaseolus vulgaris L.) is the most important legume for human consumption worldwide and it is an important source of microelements, especially iron and zinc.	Iron	156-160	brain expressed associated with NEDD4 1	Homo sapiens	7-11
29752522-4	2018	Bean biofortification breeding programs develop new varieties with high levels of Fe and Zn targeted for countries with human micronutrient deficiencies.	Iron	82-84	brain expressed associated with NEDD4 1	Homo sapiens	0-4
29956699-2	2018	The cyclic voltammetry (CV) measurements of K4[Fe(CN)6] showed that the redox current of the IDE with CNT forests (CNTF-IDE) reached the steady state much more quickly compared to that of conventional gold IDE (Au-IDE).	Iron	47-49	insulin degrading enzyme	Homo sapiens	93-96
29956699-2	2018	The cyclic voltammetry (CV) measurements of K4[Fe(CN)6] showed that the redox current of the IDE with CNT forests (CNTF-IDE) reached the steady state much more quickly compared to that of conventional gold IDE (Au-IDE).	Iron	47-49	ciliary neurotrophic factor	Homo sapiens	115-119
29956699-2	2018	The cyclic voltammetry (CV) measurements of K4[Fe(CN)6] showed that the redox current of the IDE with CNT forests (CNTF-IDE) reached the steady state much more quickly compared to that of conventional gold IDE (Au-IDE).	Iron	47-49	insulin degrading enzyme	Homo sapiens	120-123
29956699-2	2018	The cyclic voltammetry (CV) measurements of K4[Fe(CN)6] showed that the redox current of the IDE with CNT forests (CNTF-IDE) reached the steady state much more quickly compared to that of conventional gold IDE (Au-IDE).	Iron	47-49	insulin degrading enzyme	Homo sapiens	120-123
29980709-0	2018	Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis.	Iron	0-4	ADAM metallopeptidase domain 17	Homo sapiens	23-30
29980709-4	2018	Our results show that iron-overload in hepatocytes/macrophages is due to an increased expression of iron-loading receptors and CD163 signaling cascade.	Iron	22-26	CD163 molecule	Homo sapiens	127-132
29980709-5	2018	Increase in labile iron pool induces expression of iron-loading, oxidative-stress and inflammatory genes along with expression of CD163 and ADAM17.	Iron	19-23	CD163 molecule	Homo sapiens	130-135
29980709-5	2018	Increase in labile iron pool induces expression of iron-loading, oxidative-stress and inflammatory genes along with expression of CD163 and ADAM17.	Iron	19-23	ADAM metallopeptidase domain 17	Homo sapiens	140-146
29980709-6	2018	Increased liver iron correlated with circulatory iron, TNF-alpha, macrophage activation (sCD163) and peroxide-stress in CD163+macrophages in patients who were iron-overloaded and died.	Iron	16-20	CD163 molecule	Homo sapiens	90-95
29980709-10	2018	These results suggest that iron mediates inflammation through ADAM17 induction, resulting in macrophage activation and increased shedding of TNF-alpha and sCD163.	Iron	27-31	ADAM metallopeptidase domain 17	Homo sapiens	62-68
29980709-11	2018	These events could be inhibited with iron chelation or with ADAM17-blockade, postulating a therapeutic strategy for SAH patients with iron overload.	Iron	134-138	ADAM metallopeptidase domain 17	Homo sapiens	60-66
30002810-0	2018	Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington"s disease.	Iron	26-30	aconitase 1	Mus musculus	58-62
30002810-5	2018	Iron homeostatic proteins including iron response protein 1 (IRP1), transferrin (Tf), ferritin and transferrin receptor (TfR) were determined by using western blotting and immunohistochemistry, and their relative expression levels of RNA were measured by RT-PCR in both N171-82Q HD transgenic mice and HEK293 cells expressing N-terminal of huntingtin.	Iron	0-4	aconitase 1	Mus musculus	36-59
29885280-2	2018	It has been demonstrated that the oxidized species of Cl2 NQ and ascorbate serve as intermediates capable of accepting electrons from the iron-sulfur cluster FX of PS I.	Iron	138-142	endogenous retrovirus group W member 5	Homo sapiens	54-57
29457657-3	2018	H-ferritin has been identified as the iron delivery protein for oligodendrocytes, whereas Sema4A causes a direct cytotoxic effect.	Iron	38-42	ferritin heavy polypeptide 1	Mus musculus	0-10
29457657-5	2018	Here, we demonstrate that, similar to rodents, human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor.	Iron	146-150	ferritin heavy polypeptide 1	Mus musculus	123-133
29417224-10	2018	Gelatin zymography showed dietary iron restriction decreased both renal MMP-2 and MMP-9 activities in SHR-SP at 15 weeks old.	Iron	34-38	matrix metallopeptidase 9	Rattus norvegicus	82-87
29417224-12	2018	Furthermore, dietary iron restriction decreased renal fibrosis, renal MMP-2 and MMP-9 activities, renal TGFbeta-RI expression, and Smad2 phosphorylation in rats with unilateral ureteral obstruction.	Iron	21-25	matrix metallopeptidase 9	Rattus norvegicus	80-85
29658100-4	2018	NO in root tips is increased significantly above levels elsewhere in the root and is involved in the arrest of primary root tip zone growth under excess Fe, at least in part related to NO-induced K+ loss via SNO1 (sensitive to nitric oxide 1)/SOS4 (salt overly sensitive 4) and reduced root tip zone cell viability.	Iron	153-155	pfkB-like carbohydrate kinase family protein	Arabidopsis thaliana	243-247
29658100-6	2018	We conclude that excess Fe attenuates root growth by effecting an increase in root tip zone NO, and that this attenuation is related to NO-mediated alterations in K+ homeostasis, partly via SNO1/SOS4.	Iron	24-26	pfkB-like carbohydrate kinase family protein	Arabidopsis thaliana	195-199
29897813-5	2018	In vitro studies demonstrated that NMDA treatment increased the expression of iron importer divalent metal transporter 1 (DMT1) and decreased the expression of iron exporter ferropotin 1 (Fpn1), which were dependent on iron regulatory protein 1 (IRP1).	Iron	78-82	RoBo-1	Rattus norvegicus	92-120
29897813-5	2018	In vitro studies demonstrated that NMDA treatment increased the expression of iron importer divalent metal transporter 1 (DMT1) and decreased the expression of iron exporter ferropotin 1 (Fpn1), which were dependent on iron regulatory protein 1 (IRP1).	Iron	78-82	RoBo-1	Rattus norvegicus	122-126
29897813-8	2018	This suggested that 6-OHDA-induced activation of NRs might modulate the expression of DMT1 and Fpn1 via the neuronal nitric oxide synthase-IRP1 pathway.-Xu, H., Liu, X., Xia, J., Yu, T., Qu, Y., Jiang, H., Xie, J., Activation of NMDA receptors mediated iron accumulation via modulating iron transporters in Parkinson"s disease.	Iron	253-257	RoBo-1	Rattus norvegicus	86-90
30271947-1	2018	Mutations in HFE, the most common cause of hereditary hemochromatosis, lead to iron overload.	Iron	79-83	homeostatic iron regulator	Mus musculus	13-16
30271947-2	2018	The iron overload is characterized by increased iron uptake due to lower levels of the hepatic, iron regulatory hormone hepcidin.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	120-128
29498084-1	2018	Diminished beta-globin synthesis in beta-thalassemia is associated with ineffective erythropoiesis, leading to secondary iron overload caused by inappropriately low levels of hepcidin and to splenomegaly in the symptomatic thalassemias.	Iron	121-125	hepcidin antimicrobial peptide	Mus musculus	175-183
29498084-3	2018	Expression of the iron regulatory peptide hormone hepcidin is repressed by the serine protease TMPRSS6.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	50-58
29498084-4	2018	Hepcidin induction by RNAi-mediated inhibition of TMPRSS6 expression reduces iron overload and mitigates anemia in murine models of beta-thalassemia intermedia.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	0-8
29522369-0	2018	Iron overload: what"s TIMP-3 got to do with it.	Iron	0-4	TIMP metallopeptidase inhibitor 3	Homo sapiens	22-28
29627385-7	2018	The proteasome, E3 ubiquitin ligase Rsp5 and the Cdc48Npl4/Ufd1 complex are required for OLE1 activation during iron depletion.	Iron	112-116	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	89-93
29627385-10	2018	These results reveal the mechanism of OLE1 regulation when iron is scarce and identify the MGA2 auto-regulation as a potential activation strategy in multiple stresses.	Iron	59-63	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	38-42
29748743-14	2018	Confocal microscopy revealed nuclear translocation of Nrf2 (the key event in Keap1/Nrf2 signaling) induced by apo-rhLF (iron-free, RPMI-1640).	Iron	120-124	kelch-like ECH-associated protein 1	Mus musculus	77-82
29707087-8	2018	Conclusions: Our results suggest that higher level of NGAL is a risk factor for oxidative stress, as measured by AOPP levels, in dialysis patients receiving intravenous iron.	Iron	169-173	lipocalin 2	Homo sapiens	54-58
29707087-9	2018	Our findings could identify dialysis patients who are at higher risk from iron supplementation via measurement of NGAL levels.	Iron	74-78	lipocalin 2	Homo sapiens	114-118
28345492-2	2018	The drug has oxidizing potential and as an adverse effect, it can convert the ferrous form of iron in erythrocytes to its ferric form resulting in the formation of methemoglobin which makes the heme component incapable of carrying oxygen.	Iron	94-98	hemoglobin subunit gamma 2	Homo sapiens	164-177
29899851-3	2018	mRNA levels of divalent metal transporter 1 and transferrin receptor 1, which stimulate iron absorption and excretion, were enhanced in small intestine.	Iron	88-92	RoBo-1	Rattus norvegicus	15-70
29784770-2	2018	Here, our studies showed that restriction of Fe-S cluster biogenesis not only compromised mitochondrial oxidative metabolism but also resulted in decreased overall histone acetylation and increased H3K9me3 levels in the nucleus and increased acetylation of alpha-tubulin in the cytosol by decreasing the lipoylation of the pyruvate dehydrogenase complex, decreasing levels of succinate dehydrogenase and the histone acetyltransferase ELP3, and increasing levels of the tubulin acetyltransferase MEC17.	Iron	45-49	elongator acetyltransferase complex subunit 3	Homo sapiens	434-438
29872401-9	2018	Conclusion: These data demonstrated, for the first time, that an excess of obtainable iron caused by disordered IL-10 and IL-22 was involved in the pathogenesis of some HAPC patients.	Iron	86-90	interleukin 10	Homo sapiens	112-117
29872401-9	2018	Conclusion: These data demonstrated, for the first time, that an excess of obtainable iron caused by disordered IL-10 and IL-22 was involved in the pathogenesis of some HAPC patients.	Iron	86-90	interleukin 22	Homo sapiens	122-127
29659256-6	2018	Initial metal-depletion studies demonstrate that mCP depletes multiple first-row transition metal ions, including Mn, Fe, Ni, Cu, and Zn, from complex microbial growth medium, indicating that mCP binds multiple nutrient metals with high affinity.	Iron	118-120	CD46 antigen, complement regulatory protein	Mus musculus	49-52
29659256-6	2018	Initial metal-depletion studies demonstrate that mCP depletes multiple first-row transition metal ions, including Mn, Fe, Ni, Cu, and Zn, from complex microbial growth medium, indicating that mCP binds multiple nutrient metals with high affinity.	Iron	118-120	CD46 antigen, complement regulatory protein	Mus musculus	192-195
29867869-8	2018	The latter in combination with a flor-yeast-specific mutation in the Aft1 transcription factor gene is likely to be responsible for the discovered phenotype of increased iron sensitivity and improved iron uptake of analyzed strains.	Iron	170-174	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	69-73
29867869-8	2018	The latter in combination with a flor-yeast-specific mutation in the Aft1 transcription factor gene is likely to be responsible for the discovered phenotype of increased iron sensitivity and improved iron uptake of analyzed strains.	Iron	200-204	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	69-73
28874056-9	2018	INNOVATION: CP alterations in iron contents were mediated through DMT1(-IRE) and changes in ROS levels, which in turn attenuated the progression of AD through the Erk/p38 and Bcl-2/Bax signaling pathways.	Iron	30-34	BCL2-associated X protein	Mus musculus	181-184
29614218-7	2018	We demonstrate that this approach is efficient by studying the spin state energetics of a series of iron complexes modeling important intermediates in oxidative catalytic processes in chemistry and biochemistry.	Iron	100-104	spindlin 1	Homo sapiens	63-67
29686088-3	2018	In mice treated with the Fe chelator deferiprone (DFP), intracellular Fe levels, as reflected in transferrin receptor mRNA expression, were reduced.	Iron	25-27	transferrin	Mus musculus	97-108
29774023-3	2018	Since ferritin heavy chain (FtH) is a major intracellular source of reserve iron in the host, we hypothesized that the lack of FtH would cause dysregulated iron homeostasis to exacerbate TB disease.	Iron	76-80	ferritin heavy polypeptide 1	Mus musculus	28-31
29373036-7	2018	Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1beta and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3-/- livers.	Iron	173-177	chemokine (C-C motif) ligand 2	Mus musculus	101-135
29452354-9	2018	In vivo genetic analysis indicates that alpha-syn dysregulates iron homeostasis in worm dopaminergic neurons, possibly by inhibiting SNX-3-mediated recycling of a membrane-bound ortholog of Cp (F21D5.3), the iron exporter ferroportin (FPN1.1), or both.	Iron	63-67	Snx3p	Saccharomyces cerevisiae S288C	133-138
29452354-9	2018	In vivo genetic analysis indicates that alpha-syn dysregulates iron homeostasis in worm dopaminergic neurons, possibly by inhibiting SNX-3-mediated recycling of a membrane-bound ortholog of Cp (F21D5.3), the iron exporter ferroportin (FPN1.1), or both.	Iron	208-212	Snx3p	Saccharomyces cerevisiae S288C	133-138
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	78-82	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	39-43
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	78-82	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	45-50
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	163-167	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	39-43
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	163-167	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	45-50
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	163-167	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	152-156
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	163-167	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	39-43
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	163-167	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	45-50
29626156-7	2018	A mutant with constitutive activity of Gcn2 (GCN2c ) shows less repression of iron transport genes by amino acids and increased nuclear localization of Aft1 in an iron-poor medium, and increases iron content in this medium.	Iron	163-167	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	152-156
29626156-9	2018	Accordingly, the GCN2c mutant has strongly reduced activity of succinate dehydrogenase, an iron-sulfur mitochondrial enzyme, and is unable to grow in media with very low iron or with galactose instead of glucose, conditions where formation of ISCs is specially needed.	Iron	91-95	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	17-22
29626156-9	2018	Accordingly, the GCN2c mutant has strongly reduced activity of succinate dehydrogenase, an iron-sulfur mitochondrial enzyme, and is unable to grow in media with very low iron or with galactose instead of glucose, conditions where formation of ISCs is specially needed.	Iron	170-174	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	17-22
29626156-10	2018	This mechanism adjusts the uptake of iron to the needs of amino acid biosynthesis and expands the list of Gcn4-independent activities of the Gcn2-eIF2alpha regulatory system.	Iron	37-41	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	141-145
29489330-2	2018	Here, we demonstrate the reversible control of the oxidation and spin state in a single Fe porphyrin molecule in the force field of the tip of a scanning tunneling microscope.	Iron	88-90	spindlin 1	Homo sapiens	65-69
29690733-9	2018	The results of TRAP staining and pits formation also showed that osteoclast proliferation and activity in group Hepc reduced significantly when compared with those in Fe group (t=4.295, 7.557, both P&lt;0.05).	Iron	167-169	hepcidin antimicrobial peptide	Mus musculus	112-116
29690733-10	2018	Conclusion: The overexpression of hepcidin can down-regulate the content of ferritin in iron-accumulating mice and inhibit the proliferation, differentiation and activity of osteoclasts, and improve the bone mass.	Iron	88-92	hepcidin antimicrobial peptide	Mus musculus	34-42
29156406-1	2018	Herein, a new type of multifunctional iron based metal-organic frameworks (PdNPs@Fe-MOFs) has been synthesized by assembly palladium nanoparticles on the surface of Fe-MIL-88NH2 MOFs microcrystals, and first applied in electrochemical biosensor for ultrasensitive detection of microRNA-122 (miR-122, a biomarker of drug-induced liver injury).	Iron	38-42	microRNA 122	Homo sapiens	291-298
29156406-1	2018	Herein, a new type of multifunctional iron based metal-organic frameworks (PdNPs@Fe-MOFs) has been synthesized by assembly palladium nanoparticles on the surface of Fe-MIL-88NH2 MOFs microcrystals, and first applied in electrochemical biosensor for ultrasensitive detection of microRNA-122 (miR-122, a biomarker of drug-induced liver injury).	Iron	81-83	microRNA 122	Homo sapiens	291-298
29168009-8	2018	Increased brain iron concentration was linearly correlated with an increase in L-ferritin expression, and TMHF diet was found to increase L-ferritin within the olfactory bulb, neocortex, pallidum, thalamus, corpus callosum, CA3 regions of the hippocampus, and substantia nigra.	Iron	16-20	ferritin light polypeptide 1	Mus musculus	79-89
29364516-0	2018	Iron promotes alpha-synuclein aggregation and transmission by inhibiting TFEB-mediated autophagosome-lysosome fusion.	Iron	0-4	transcription factor EB	Mus musculus	73-77
29364516-9	2018	Furthermore, iron decreased the expression of nuclear transcription factor EB (TFEB), a master transcriptional regulator of autophagosome-lysosome fusion, and inhibited its nuclear translocation through activating AKT/mTORC1 signaling.	Iron	13-17	transcription factor EB	Mus musculus	54-77
29364516-9	2018	Furthermore, iron decreased the expression of nuclear transcription factor EB (TFEB), a master transcriptional regulator of autophagosome-lysosome fusion, and inhibited its nuclear translocation through activating AKT/mTORC1 signaling.	Iron	13-17	transcription factor EB	Mus musculus	79-83
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	transcription factor EB	Mus musculus	157-161
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	transcription factor EB	Mus musculus	157-161
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	transcription factor EB	Mus musculus	157-161
29364516-10	2018	After silencing TFEB, ratios of alpha-synuclein aggregation and transmission were not significantly altered by the presence of iron; on the other hand, when TFEB was over-expressed, the transmission of alpha-synuclein induced by iron was obviously reversed; suggesting the mechanism by which iron promotes alpha-synuclein transmission may be mediated by TFEB.	Iron	229-233	transcription factor EB	Mus musculus	157-161
29364516-11	2018	Taken together, our data reveal a previously unknown relationship between iron and alpha-synuclein, and identify TFEB as not only a potential target for preventing alpha-synuclein transmission, but also a critical factor for iron-induced alpha-synuclein aggregation and transmission.	Iron	225-229	transcription factor EB	Mus musculus	113-117
28485407-3	2018	Here we show that the deletion of the iron trafficking protein lipocalin-2 (LCN2) induces deficits in NSCs proliferation and commitment, with impact on the hippocampal-dependent contextual fear discriminative task.	Iron	38-42	lipocalin 2	Homo sapiens	63-74
28485407-3	2018	Here we show that the deletion of the iron trafficking protein lipocalin-2 (LCN2) induces deficits in NSCs proliferation and commitment, with impact on the hippocampal-dependent contextual fear discriminative task.	Iron	38-42	lipocalin 2	Homo sapiens	76-80
28485407-6	2018	LCN2 is, therefore, a novel key modulator of neurogenesis that, through iron, controls NSCs cell cycle progression and death, self-renewal, proliferation and differentiation and, ultimately, hippocampal function.	Iron	72-76	lipocalin 2	Homo sapiens	0-4
29429726-1	2018	This paper describes a simple, selective and sensitive colorimetric sensing of Cr6+ ions using beta-Cyclodextrin (beta-CD) functionalized gold-iron nanoparticles (beta-CD/Au-FeNPs).	Iron	143-147	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	79-82
29682205-7	2018	We conclude that specific iron compounds affect cell signaling differently and some may increase the risk of colon cancer advancement in an amphiregulin-dependent fashion.	Iron	26-30	amphiregulin	Homo sapiens	140-152
29694211-4	2018	The generality and efficiency of our method is demonstrated on a complex transformation of C15 interstitial defects in iron and double kink nucleation on a screw dislocation in tungsten, the latter system consisting of more than 120 000 atoms.	Iron	119-123	placenta associated 8	Homo sapiens	91-94
29417967-4	2018	Based on reports for Pc-based systems, the negative magnetoresistance (MR) effect for TPP[Fe(tbp)Br2]2 was expected to be smaller than that for TPP[Fe(tbp)(CN)2]2.	Iron	90-92	TATA-box binding protein	Homo sapiens	93-96
29305420-1	2018	Iron is universally important to cellular metabolism, and mitoferrin-1 and -2 have been proposed to be the iron importers of mitochondria, the cell"s assembly plant of heme and iron-sulfur clusters.	Iron	107-111	solute carrier family 25 member 37	Homo sapiens	58-77
29305420-1	2018	Iron is universally important to cellular metabolism, and mitoferrin-1 and -2 have been proposed to be the iron importers of mitochondria, the cell"s assembly plant of heme and iron-sulfur clusters.	Iron	177-181	solute carrier family 25 member 37	Homo sapiens	58-77
29305420-4	2018	Despite the clear importance of Mfrn1 in iron utilization, its transport activity has not been demonstrated unambiguously.	Iron	41-45	solute carrier family 25 member 37	Homo sapiens	32-37
29305420-7	2018	Mfrn1 was incorporated into defined liposomes, and iron transport was reconstituted in vitro, demonstrating that Mfrn1 can transport iron.	Iron	51-55	solute carrier family 25 member 37	Homo sapiens	113-118
29305420-7	2018	Mfrn1 was incorporated into defined liposomes, and iron transport was reconstituted in vitro, demonstrating that Mfrn1 can transport iron.	Iron	133-137	solute carrier family 25 member 37	Homo sapiens	0-5
29556203-0	2018	MyD88 Adaptor Protein Is Required for Appropriate Hepcidin Induction in Response to Dietary Iron Overload in Mice.	Iron	92-96	myeloid differentiation primary response gene 88	Mus musculus	0-5
29556203-0	2018	MyD88 Adaptor Protein Is Required for Appropriate Hepcidin Induction in Response to Dietary Iron Overload in Mice.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	50-58
29556203-2	2018	The peptide hormone hepcidin is central to the control of the amount of iron absorbed from the diet and iron recycling from macrophages.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	20-28
29556203-2	2018	The peptide hormone hepcidin is central to the control of the amount of iron absorbed from the diet and iron recycling from macrophages.	Iron	104-108	hepcidin antimicrobial peptide	Mus musculus	20-28
29556203-4	2018	In this study, we analyzed the regulation of iron metabolism in MyD88-/- mice to further investigate MyD88 involvement in iron sensing and hepcidin induction.	Iron	122-126	myeloid differentiation primary response gene 88	Mus musculus	101-106
29556203-5	2018	We show that mice lacking MyD88 accumulate significantly more iron in their livers than wild-type counterparts in response to dietary iron loading as they are unable to appropriately control hepcidin levels.	Iron	62-66	myeloid differentiation primary response gene 88	Mus musculus	26-31
29556203-5	2018	We show that mice lacking MyD88 accumulate significantly more iron in their livers than wild-type counterparts in response to dietary iron loading as they are unable to appropriately control hepcidin levels.	Iron	134-138	myeloid differentiation primary response gene 88	Mus musculus	26-31
29556203-7	2018	In conclusion, our results reveal a previously unknown link between MyD88 and iron homeostasis, and provide new insights into the regulation of hepcidin through the iron-sensing pathway.	Iron	78-82	myeloid differentiation primary response gene 88	Mus musculus	68-73
29556203-7	2018	In conclusion, our results reveal a previously unknown link between MyD88 and iron homeostasis, and provide new insights into the regulation of hepcidin through the iron-sensing pathway.	Iron	165-169	hepcidin antimicrobial peptide	Mus musculus	144-152
29309586-0	2018	Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.	Iron	35-39	cytosolic iron-sulfur assembly component 1	Homo sapiens	75-80
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	60-64	cytosolic iron-sulfur assembly component 1	Homo sapiens	113-118
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	60-64	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	131-136
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	cytosolic iron-sulfur assembly component 1	Homo sapiens	113-118
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	131-136
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	cytosolic iron-sulfur assembly component 1	Homo sapiens	113-118
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	131-136
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	cytosolic iron-sulfur assembly component 1	Homo sapiens	113-118
29309586-3	2018	Recently, a complex formed of components of the cytoplasmic Fe-S cluster assembly (CIA) machinery, consisting of CIAO1, FAM96B and MMS19, was found to deliver Fe-S clusters to a subset of proteins involved in DNA metabolism, but it was unclear how this complex acquired its fully synthesized Fe-S clusters, because Fe-S clusters have been alleged to be assembled de novo solely in the mitochondrial matrix.	Iron	159-163	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	131-136
29394034-7	2018	Furthermore, Fe-binding and Fe-regulatory proteins, such as hepcidin, lipocalin-2/NGAL, heme oxygenase-1, ferritin, and iron-sulfur clusters can display antitumor properties under specific conditions and in particular cancer types.	Iron	13-15	lipocalin 2	Homo sapiens	70-81
29394034-7	2018	Furthermore, Fe-binding and Fe-regulatory proteins, such as hepcidin, lipocalin-2/NGAL, heme oxygenase-1, ferritin, and iron-sulfur clusters can display antitumor properties under specific conditions and in particular cancer types.	Iron	13-15	lipocalin 2	Homo sapiens	82-86
29434729-6	2018	There were marked abnormalities in iron regulation gene expression between the AA and composite model groups, as seen by the significant decrease of hepcidin expression in the liver (P&lt;0.01) that paralleled the changes in BMP6, SMAD4, and TfR2.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	149-157
29434729-6	2018	There were marked abnormalities in iron regulation gene expression between the AA and composite model groups, as seen by the significant decrease of hepcidin expression in the liver (P&lt;0.01) that paralleled the changes in BMP6, SMAD4, and TfR2.	Iron	35-39	transferrin receptor 2	Mus musculus	242-246
28401620-0	2018	ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12.	Iron	99-103	ATPase H+/K+ transporting subunit alpha	Homo sapiens	0-5
29105162-3	2018	One-electron reduction of this compound under CO occurred with the loss of LiCl to form the square-pyramidal monovalent iron in [(PNN)Fe(CO)2 ], which was characterized by IR, Mossbauer, and EPR spectroscopy, X-ray diffraction, and DFT calculations.	Iron	120-124	pinin, desmosome associated protein	Homo sapiens	130-133
29105162-5	2018	The product K[(PNN)Fe(CO)2 ] contains saturated, five-coordinate Fe0 ; the (PNN)Fe subunit is anionic and the K+ cations cluster close to the pyrazolate side of the two CO ligands.	Iron	65-68	pinin, desmosome associated protein	Homo sapiens	15-18
29105162-5	2018	The product K[(PNN)Fe(CO)2 ] contains saturated, five-coordinate Fe0 ; the (PNN)Fe subunit is anionic and the K+ cations cluster close to the pyrazolate side of the two CO ligands.	Iron	19-21	pinin, desmosome associated protein	Homo sapiens	15-18
29361561-1	2018	Mms19 encodes a cytosolic iron-sulphur assembly component.	Iron	26-30	Mms19	Drosophila melanogaster	0-5
29472934-1	2017	Siroheme, an iron-containing tetrapyrrole, is the prosthetic group of nitrite reductase (NiR) and sulfite reductase (SiR); it is synthesized from uroporphyrinogen III, an intermediate of chlorophyll biosynthesis, and is required for nitrogen (N) and sulfur (S) assimilation.	Iron	13-17	sulfite reductase	Arabidopsis thaliana	98-115
29472934-1	2017	Siroheme, an iron-containing tetrapyrrole, is the prosthetic group of nitrite reductase (NiR) and sulfite reductase (SiR); it is synthesized from uroporphyrinogen III, an intermediate of chlorophyll biosynthesis, and is required for nitrogen (N) and sulfur (S) assimilation.	Iron	13-17	sulfite reductase	Arabidopsis thaliana	117-120
29352149-1	2018	We experimentally study nanowire-shaped spin-Hall nano-oscillators based on nanometer-thick epitaxial films of Yttrium Iron Garnet grown on top of a layer of Pt.	Iron	119-123	spindlin 1	Homo sapiens	40-44
29317744-0	2018	A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese.	Iron	72-76	RoBo-1	Rattus norvegicus	39-43
29225034-4	2018	Overexpression or knockout of MAGE-F1 altered Fe-S incorporation into MMS19-dependent DNA repair enzymes, DNA repair capacity, sensitivity to DNA-damaging agents, and iron homeostasis.	Iron	46-50	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	70-75
29298794-7	2018	Potential mechanisms of FGF23 dysregulation are discussed, with the aim of raising awareness of this significant side effect for prescribers of chronic intravenous iron supplementation, and to help guide future studies to determine the safety of FCM in all patient populations.	Iron	164-168	fibroblast growth factor 23	Homo sapiens	24-29
29219710-0	2018	SNX1-mediated protein recycling: Piecing together the tissue-specific regulation of arabidopsis iron acquisition.	Iron	96-100	sorting nexin 1	Arabidopsis thaliana	0-4
29219710-4	2018	Based on this, we explore the tissue-specific regulation of iron import, specifically concentrating on the factors involved in the expression and recycling of IRT1 in root tissues.	Iron	60-64	iron-regulated transporter 1	Arabidopsis thaliana	159-163
29219710-5	2018	We propose that different processes affecting IRT1 regulation may lead to similar outcomes, allowing for fine-tuning iron acquisition and distribution.	Iron	117-121	iron-regulated transporter 1	Arabidopsis thaliana	46-50
29874654-1	2018	BACKGROUND: Serum phosphate and vitamin D receptor activator regulate fibroblast growth factor 23 (FGF23), and iron may modulate FGF23 metabolism.	Iron	111-115	fibroblast growth factor 23	Homo sapiens	129-134
28793778-7	2018	In Prx2-/- mice, the loss of Hamp response was also observed after administration of a single dose of oral iron.	Iron	107-111	hepcidin antimicrobial peptide	Mus musculus	29-33
28791741-2	2018	LOX catalytic activity depends on the presence of iron in the active site and the iron removal is also able to affect the membrane binding properties of the enzyme.	Iron	50-54	lysyl oxidase	Homo sapiens	0-3
28791741-2	2018	LOX catalytic activity depends on the presence of iron in the active site and the iron removal is also able to affect the membrane binding properties of the enzyme.	Iron	82-86	lysyl oxidase	Homo sapiens	0-3
28791741-4	2018	In this study, we have analyzed by molecular dynamics simulations the conformational changes induced by iron removal in 5-LOX.	Iron	104-108	lysyl oxidase	Homo sapiens	122-125
29763925-2	2018	The hepcidin-ferroportin axis plays the key role in regulation of iron homeostasis and modulation of this signaling could be a potential therapeutic strategy in the treatment of these diseases.	Iron	66-70	hepcidin antimicrobial peptide	Mus musculus	4-12
28859237-2	2018	In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis.	Iron	209-213	hepcidin antimicrobial peptide	Mus musculus	157-165
28859237-6	2018	Importantly, in the liver, absence of CBS caused both a reduction in the transcriptional factor nuclear factor erythroid 2-related factor-2 and an up-regulation of hepcidin that led to a decrease in the iron export protein ferroportin 1.	Iron	203-207	hepcidin antimicrobial peptide	Mus musculus	164-172
28988245-6	2018	Bioactivation of CLC-1011 in aortic tissue was measured by electron paramagnetic resonance spectroscopy using an iron-based spin trap for  NO.	Iron	113-117	Charcot-Leyden crystal galectin	Homo sapiens	17-20
29435183-2	2018	Regulation of intracellular iron occurs via a ferritinophagic process involving NCOA4 (Nuclear Receptor Coactivator 4), represented by two major isoforms (NCOA4alpha and NCOA4beta), whose contribution to ovarian cancer biology remains uninvestigated.	Iron	28-32	nuclear receptor coactivator 4	Homo sapiens	80-85
29435183-2	2018	Regulation of intracellular iron occurs via a ferritinophagic process involving NCOA4 (Nuclear Receptor Coactivator 4), represented by two major isoforms (NCOA4alpha and NCOA4beta), whose contribution to ovarian cancer biology remains uninvestigated.	Iron	28-32	nuclear receptor coactivator 4	Homo sapiens	87-117
29312418-0	2017	Common Bean Fe Biofortification Using Model Species" Lessons.	Iron	12-14	brain expressed associated with NEDD4 1	Homo sapiens	7-11
29188831-3	2017	The characteristics of current-voltage and spin-resolved transmission spectra pointed out that Ni complexes are non-polarized, while Fe and Mn complexes exhibit high polarization and can be regarded as excellent candidates for spin-filtering materials with high spin-filtering efficiency.	Iron	133-135	spindlin 1	Homo sapiens	227-231
29188831-3	2017	The characteristics of current-voltage and spin-resolved transmission spectra pointed out that Ni complexes are non-polarized, while Fe and Mn complexes exhibit high polarization and can be regarded as excellent candidates for spin-filtering materials with high spin-filtering efficiency.	Iron	133-135	spindlin 1	Homo sapiens	227-231
28905064-0	2017	Mechanochemical synthesis of high coercivity Nd2(Fe,Co)14B magnetic particles.	Iron	49-51	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	45-48
28905064-2	2017	We report a novel mechanochemical process for the synthesis of Nd2(Fe,Co)14B magnetic particles with a high coercivity of 12.4 kOe.	Iron	67-69	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	63-66
28905064-4	2017	The formation mechanism of Nd2(Fe,Co)14B changed with increasing CaO content, and the average crystal size of the Nd2(Fe,Co)14B particles also increased, resulting in an increase in the coercivity values.	Iron	31-33	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	27-30
28905064-4	2017	The formation mechanism of Nd2(Fe,Co)14B changed with increasing CaO content, and the average crystal size of the Nd2(Fe,Co)14B particles also increased, resulting in an increase in the coercivity values.	Iron	118-120	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	27-30
28905064-4	2017	The formation mechanism of Nd2(Fe,Co)14B changed with increasing CaO content, and the average crystal size of the Nd2(Fe,Co)14B particles also increased, resulting in an increase in the coercivity values.	Iron	118-120	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	114-117
29185409-1	2017	Methemoglobin (MetHb) is a form of hemoglobin which contains iron in ferric state.	Iron	61-65	hemoglobin subunit gamma 2	Homo sapiens	0-13
29185409-1	2017	Methemoglobin (MetHb) is a form of hemoglobin which contains iron in ferric state.	Iron	61-65	hemoglobin subunit gamma 2	Homo sapiens	15-20
29550798-9	2017	NGAL levels correlated with CRP (r = 0.49), ESR (r = 0.48) and iron concentrations (r = -0.63), but not with faecal calprotectin.	Iron	63-67	lipocalin 2	Homo sapiens	0-4
28893916-2	2017	To improve our understanding of these relationships, we examined the pathways involved in regulation of the master controller of iron metabolism, the hormone hepcidin, in malaria infection.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	158-166
28924039-1	2017	Systemic iron homeostasis is maintained by regulation of iron absorption in the duodenum, iron recycling from erythrocytes, and iron mobilization from the liver and is controlled by the hepatic hormone hepcidin.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	202-210
28794066-7	2017	alpha-ICs inhibit bacterial growth by acidifying urine and secreting neutrophil gelatinase-associated lipocalin (NGAL) that chelates siderophore-containing iron.	Iron	156-160	lipocalin 2	Homo sapiens	69-111
28794066-7	2017	alpha-ICs inhibit bacterial growth by acidifying urine and secreting neutrophil gelatinase-associated lipocalin (NGAL) that chelates siderophore-containing iron.	Iron	156-160	lipocalin 2	Homo sapiens	113-117
28798083-1	2017	Iron homeostasis is tightly regulated, and the peptide hormone hepcidin is considered to be a principal regulator of iron metabolism.	Iron	117-121	hepcidin antimicrobial peptide	Mus musculus	63-71
28798083-2	2017	Previous studies in a limited number of mouse strains found equivocal sex- and strain-dependent differences in mRNA and serum levels of hepcidin and reported conflicting data on the relationship between hepcidin (Hamp1) mRNA levels and iron status.	Iron	236-240	hepcidin antimicrobial peptide	Mus musculus	203-211
28798083-2	2017	Previous studies in a limited number of mouse strains found equivocal sex- and strain-dependent differences in mRNA and serum levels of hepcidin and reported conflicting data on the relationship between hepcidin (Hamp1) mRNA levels and iron status.	Iron	236-240	hepcidin antimicrobial peptide	Mus musculus	213-218
28669019-12	2017	These results suggest that impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD.	Iron	123-127	RoBo-1	Rattus norvegicus	72-77
28774878-5	2017	Overexpression of Pfn2 in HeLa and Hepa1-6 cells reduced their metabolically active iron pool.	Iron	84-88	profilin 2	Homo sapiens	18-22
29073196-3	2017	Recently, FGF23 plasma levels were shown to be increased in mice after treatment with hypoxia inducible factor-proline hydroxylase (HIF-PH) inhibitors which are strong inducers of erythropoietin and erythropoiesis and are known to modulate iron uptake and availability.	Iron	240-244	fibroblast growth factor 23	Mus musculus	10-15
29089902-0	2017	Pulmonary Iron Homeostasis in Hepcidin Knockout Mice.	Iron	10-14	hepcidin antimicrobial peptide	Mus musculus	30-38
29089902-7	2017	The accumulation of iron in the lung macrophages of hepcidin KO mice contrasts with splenic and hepatic macrophages which contain low iron levels as we have previously reported.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	52-60
28993663-4	2017	Biodistribution studies revealed increased transferrin-bound iron accumulation in the kidneys of albuminuric NZB/W mice, but no difference in the accumulation of non-transferrin bound iron or ferritin.	Iron	61-65	transferrin	Mus musculus	43-54
28993663-6	2017	Expression of transferrin receptor and 24p3R were reduced in tubules from NZB/W compared to NZW mice, while ferroportin expression was unchanged and ferritin expression increased, consistent with increased iron accumulation and compensatory downregulation of uptake pathways.	Iron	206-210	transferrin	Mus musculus	14-25
28980995-10	2017	OH-Gad seems to be a potentially new mineral, the first simultaneously hydroxyl- and iron-dominant member of the gadolinite subgroup.	Iron	85-89	glutamate decarboxylase 1	Homo sapiens	3-6
28385068-2	2017	Transforming growth differentiation factor-15 (GDF-15) plays an important role in erythropoiesis and iron regulation.	Iron	101-105	growth differentiation factor 15	Homo sapiens	13-45
28385068-2	2017	Transforming growth differentiation factor-15 (GDF-15) plays an important role in erythropoiesis and iron regulation.	Iron	101-105	growth differentiation factor 15	Homo sapiens	47-53
28385068-13	2017	DISCUSSION: Our data indicated that GDF-15 plays an important role in iron metabolism in SAA.	Iron	70-74	growth differentiation factor 15	Homo sapiens	36-42
28390898-0	2017	Ethylene response factor AtERF72 negatively regulates Arabidopsis thaliana response to iron deficiency.	Iron	87-91	ethylene-responsive element binding protein	Arabidopsis thaliana	25-32
28390898-3	2017	Here, we investigated the role of ERF72 in response to iron deficiency in Arabidopsis thaliana.	Iron	55-59	ethylene-responsive element binding protein	Arabidopsis thaliana	34-39
28979267-0	2017	Iron Handling in Tumor-Associated Macrophages-Is There a New Role for Lipocalin-2?	Iron	0-4	lipocalin 2	Homo sapiens	70-81
29404495-5	2017	We found that iron overload induced significant changes in the expression of genes and metabolites involved in glucose and nicotinamide metabolism and that NNMT, an enzyme that methylates nicotinamide and regulates hepatic glucose and cholesterol metabolism, is one of the most strongly down-regulated genes in the liver in both genetic and dietary iron overload.	Iron	14-18	nicotinamide N-methyltransferase	Mus musculus	156-160
29404495-5	2017	We found that iron overload induced significant changes in the expression of genes and metabolites involved in glucose and nicotinamide metabolism and that NNMT, an enzyme that methylates nicotinamide and regulates hepatic glucose and cholesterol metabolism, is one of the most strongly down-regulated genes in the liver in both genetic and dietary iron overload.	Iron	349-353	nicotinamide N-methyltransferase	Mus musculus	156-160
29404495-7	2017	Furthermore, we demonstrated that adenoviral knockdown of NNMT in primary mouse hepatocytes exacerbates iron-induced hepatocyte toxicity and increases expression of transcriptional markers of oxidative and endoplasmic reticulum stress, while overexpression of NNMT partially reversed these effects.	Iron	104-108	nicotinamide N-methyltransferase	Mus musculus	58-62
29404495-7	2017	Furthermore, we demonstrated that adenoviral knockdown of NNMT in primary mouse hepatocytes exacerbates iron-induced hepatocyte toxicity and increases expression of transcriptional markers of oxidative and endoplasmic reticulum stress, while overexpression of NNMT partially reversed these effects.	Iron	104-108	nicotinamide N-methyltransferase	Mus musculus	260-264
29404495-8	2017	Conclusion: Iron overload alters glucose and nicotinamide transcriptional and metabolic pathways in mouse hepatocytes and decreases NNMT expression, while NNMT deficiency worsens the toxic effect of iron overload.	Iron	12-16	nicotinamide N-methyltransferase	Mus musculus	132-136
29404495-8	2017	Conclusion: Iron overload alters glucose and nicotinamide transcriptional and metabolic pathways in mouse hepatocytes and decreases NNMT expression, while NNMT deficiency worsens the toxic effect of iron overload.	Iron	199-203	nicotinamide N-methyltransferase	Mus musculus	155-159
29404495-9	2017	For these reasons, NNMT may be a drug target for the prevention of iron-induced hepatotoxicity.	Iron	67-71	nicotinamide N-methyltransferase	Mus musculus	19-23
28396286-2	2017	LCN2 limits bacterial growth by sequestering iron-containing siderophores and in mammalian liver protects against inflammation, infection, injury and other stressors.	Iron	45-49	lipocalin 2	Homo sapiens	0-4
28460224-2	2017	Within this study, colloidal properties including surface charge and suspension stability as well as mobility in porous media were studied under various conditions for two Trap-Ox Fe-zeolite representatives: Fe-BEA35 and Fe-MFI120.	Iron	180-182	TRAP	Homo sapiens	172-176
28768839-8	2017	Hemoglobin and ferritin concentrations were not independently associated with any of the inherited blood disorder genotypes.Conclusions: We found that 2 G6PD variant genotypes were associated with elevated sTfR concentrations, which limits the accuracy of sTfR as a biomarker of iron status in this population.	Iron	279-283	glucose-6-phosphate dehydrogenase	Homo sapiens	153-157
27659127-6	2017	In this context, altered hypoxia inducible factor 1alpha signaling and iron metabolism may contribute to intact FGF23 (iFGF23) production.	Iron	71-75	fibroblast growth factor 23	Homo sapiens	112-117
28819251-0	2017	G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin.	Iron	49-53	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
28819251-3	2017	Here we report that G9a exerts its oncogenic function in breast cancer by repressing hephaestin and destruction cellular iron homeostasis.	Iron	121-125	euchromatic histone lysine methyltransferase 2	Homo sapiens	20-23
28819251-4	2017	In the case of pharmacological inhibition or short hairpin RNA interference-mediated suppression of G9a, the expression and activity of hephaestin increases, leading to the observed decrease of intracellular labile iron content and the disturbance of breast cancer cell growth in vitro and in vivo.	Iron	215-219	euchromatic histone lysine methyltransferase 2	Homo sapiens	100-103
28819251-7	2017	All these suggest a G9a-dependent epigenetic program in the control of iron homeostasis and tumor growth in breast cancer.G9a is a histone methyltransferase highly expressed in several cancers including breast cancer.	Iron	71-75	euchromatic histone lysine methyltransferase 2	Homo sapiens	20-23
28819251-7	2017	All these suggest a G9a-dependent epigenetic program in the control of iron homeostasis and tumor growth in breast cancer.G9a is a histone methyltransferase highly expressed in several cancers including breast cancer.	Iron	71-75	euchromatic histone lysine methyltransferase 2	Homo sapiens	122-125
28819251-8	2017	Here the authors propose a mechanism through which G9a promotes breast cancer by regulating iron metabolism through the repression of ferroxidase hephaestin.	Iron	92-96	euchromatic histone lysine methyltransferase 2	Homo sapiens	51-54
28705644-1	2017	Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
28551141-9	2017	The detection limits (mgL-1) are 0.02/0.02 and 0.01/0.02 for determination of both forms of iron and chromium, respectively.	Iron	92-96	LLGL scribble cell polarity complex component 1	Homo sapiens	22-27
28642370-8	2017	Spectral titrations with cholesterol, in the presence of EFV or l-Glu, suggest that water displacement from the heme iron can be affected in activator-bound CYP46A1.	Iron	117-121	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	157-164
28685208-0	2017	Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells.	Iron	0-4	monoamine oxidase B	Homo sapiens	31-50
28685208-2	2017	However, the association of iron with MAO-B activity was poorly understood.	Iron	28-32	monoamine oxidase B	Homo sapiens	38-43
28685208-3	2017	Here we took advantage of highly sensitive and specific fluorescence probes to examine the change in MAO-B activity in human dopaminergic neuroblastoma (SH-SY5Y) cells upon iron exposure.	Iron	173-177	monoamine oxidase B	Homo sapiens	101-106
28685208-5	2017	In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent.	Iron	13-17	monoamine oxidase B	Homo sapiens	38-43
28685208-5	2017	In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent.	Iron	13-17	monoamine oxidase B	Homo sapiens	121-126
28685208-5	2017	In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent.	Iron	13-17	monoamine oxidase B	Homo sapiens	121-126
28685208-6	2017	These findings may suggest MAO-B is an important sensor in iron-stressed neuronal cells.	Iron	59-63	monoamine oxidase B	Homo sapiens	27-32
28341391-0	2017	Mice lacking liver-specific beta-catenin develop steatohepatitis and fibrosis after iron overload.	Iron	84-88	catenin (cadherin associated protein), beta 1	Mus musculus	28-40
28341391-7	2017	Increased injury in KO +Fe was associated with activated protein kinase B (AKT), ERK, and NF-kappaB, along with reappearance of beta-catenin and target gene Cyp2e1, which promoted lipid peroxidation and hepatic damage.	Iron	24-26	catenin (cadherin associated protein), beta 1	Mus musculus	128-140
28341391-9	2017	CONCLUSIONS: The absence of hepatic beta-catenin predisposes mice to hepatic injury and fibrosis following iron overload, which was reminiscent of hemochromatosis and associated with enhanced steatohepatitis and fibrosis.	Iron	107-111	catenin (cadherin associated protein), beta 1	Mus musculus	36-48
28341391-12	2017	Feeding high iron diet to mice that lack the beta-catenin gene in liver cells led to increased inflammation followed by fat accumulation, cell death and wound healing that mimicked human disease.	Iron	13-17	catenin (cadherin associated protein), beta 1	Mus musculus	45-57
28871946-0	2017	[Mechanism for the inhibition of proliferation and promotion of apoptosis in Huh7.5 cells by iron overload].	Iron	93-97	MIR7-3 host gene	Homo sapiens	77-81
28871946-1	2017	Objective To investigate the effect of iron overload on biological activity and apoptosis in Huh7.5 cells.	Iron	39-43	MIR7-3 host gene	Homo sapiens	93-97
28871946-8	2017	Conclusion Iron overload can inhibit the proliferation and promote the apoptosis of Huh7.5 cells through oxidative stress.	Iron	11-15	MIR7-3 host gene	Homo sapiens	84-88
28465342-0	2017	Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	11-19
28465342-0	2017	Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.	Iron	112-116	transferrin	Mus musculus	94-105
28465342-1	2017	The iron-regulatory hormone hepcidin is induced early in infection, causing iron sequestration in macrophages and decreased plasma iron; this is proposed to limit the replication of extracellular microbes, but could also promote infection with macrophage-tropic pathogens.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	28-36
28465342-1	2017	The iron-regulatory hormone hepcidin is induced early in infection, causing iron sequestration in macrophages and decreased plasma iron; this is proposed to limit the replication of extracellular microbes, but could also promote infection with macrophage-tropic pathogens.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	28-36
28465342-3	2017	Using mouse models, we show that hepcidin was selectively protective against siderophilic extracellular pathogens (Yersinia enterocolitica O9) by controlling non-transferrin-bound iron (NTBI) rather than iron-transferrin concentration.	Iron	180-184	hepcidin antimicrobial peptide	Mus musculus	33-41
28731774-4	2017	Considering the calculated spin-dependent Fe/Au interface transmittance we conclude that a nonthermal spin-dependent Seebeck effect is responsible for the generation of ultrashort spin current pulses.	Iron	42-44	spindlin 1	Homo sapiens	27-31
28731774-4	2017	Considering the calculated spin-dependent Fe/Au interface transmittance we conclude that a nonthermal spin-dependent Seebeck effect is responsible for the generation of ultrashort spin current pulses.	Iron	42-44	spindlin 1	Homo sapiens	102-106
28731774-4	2017	Considering the calculated spin-dependent Fe/Au interface transmittance we conclude that a nonthermal spin-dependent Seebeck effect is responsible for the generation of ultrashort spin current pulses.	Iron	42-44	spindlin 1	Homo sapiens	102-106
28731774-5	2017	The demonstrated rotation of spin polarization of hot electrons upon interaction with noncollinear magnetization at Au/Fe interfaces holds high potential for future spintronic devices.	Iron	119-121	spindlin 1	Homo sapiens	29-33
28438754-1	2017	Anemia suppresses liver hepcidin expression to supply adequate iron for erythropoiesis.	Iron	63-67	hepcidin antimicrobial peptide	Mus musculus	24-32
28558947-0	2017	Hemochromatosis Protein (HFE) Knockout Mice As a Novel Model of Hemochromatosis: Implications for Study and Management of Iron-Overload Cardiomyopathy.	Iron	122-126	homeostatic iron regulator	Mus musculus	25-28
28652444-3	2017	Nowadays modern analytical instruments allow to accurately calculate the content of Hemoglobin (Hb) in reticulocytes (CHr), that can be used as a guide for prescribing patients with the appropriate amount of iron.	Iron	208-212	chromate resistance; sulfate transport	Homo sapiens	118-121
28659950-4	2017	In this study, we used two F2 mapping populations to map and identify the FeFe gene as bHLH38, a homolog of subgroup Ib bHLH genes from Arabidopsis thaliana that are involved in transcriptional regulation of Fe-uptake genes in partnership with the FIT gene.	Iron	74-76	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	87-93
28435068-9	2017	Indeed, in the presence of iron, zinc homeostasis is altered, as reflected by expression changes of zinc transporters dZIP1 and dZnT1.	Iron	27-31	Zinc transporter 63C	Drosophila melanogaster	128-133
28721153-2	2017	Inflammation and iron are potential regulators of FGF-23.	Iron	17-21	fibroblast growth factor 23	Homo sapiens	50-56
28219768-3	2017	Our recent study demonstrated that 14-day-old mosaic mutant males display blood cell abnormalities associated with intravascular hemolysis, and show disturbances in the functioning of the hepcidin-ferroportin regulatory axis, which controls systemic iron homeostasis.	Iron	250-254	hepcidin antimicrobial peptide	Mus musculus	188-196
28330828-3	2017	Subsequently, eight weeks after iron repletion (190-240mg Fe/kg) we found a significant decrease in mature BDNF (14kDa) and proBDNF (18kDa and 24kDa) protein levels in the ventral hippocampus, whereas we found increases in the dorsal hippocampus.	Iron	32-36	brain derived neurotrophic factor	Homo sapiens	107-111
28432145-7	2017	To counter iron theft by Ent, neutrophils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug-of-war" for iron.	Iron	11-15	lipocalin 2	Homo sapiens	82-93
28432145-7	2017	To counter iron theft by Ent, neutrophils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug-of-war" for iron.	Iron	11-15	lipocalin 2	Homo sapiens	95-99
28432145-7	2017	To counter iron theft by Ent, neutrophils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug-of-war" for iron.	Iron	123-127	lipocalin 2	Homo sapiens	82-93
28432145-7	2017	To counter iron theft by Ent, neutrophils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug-of-war" for iron.	Iron	123-127	lipocalin 2	Homo sapiens	95-99
28505283-4	2017	The EAE lesion-associated liberation of iron (due to loss of iron-containing myelin) was associated with altered expression of the iron metabolic markers FtH1, lactoferrin, hephaestin, and ceruloplasmin.	Iron	40-44	ferritin heavy chain	Callithrix jacchus	154-158
28424257-1	2017	Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8.9 mg Fe, 2.7 mg Zn, 1050 mug retinoic acid equivalent vitamin A, and 5.5 mug vitamin B-12) or a control snack (mean: 150 kcal, 2.0 mg Fe, 0.9 mg Zn, 0 mug retinoic acid equivalent vitamin A, and 0 mug vitamin B-12) 5 d/wk for 6 mo.	Iron	379-383	arylsulfatase F	Homo sapiens	221-224
28424257-1	2017	Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8.9 mg Fe, 2.7 mg Zn, 1050 mug retinoic acid equivalent vitamin A, and 5.5 mug vitamin B-12) or a control snack (mean: 150 kcal, 2.0 mg Fe, 0.9 mg Zn, 0 mug retinoic acid equivalent vitamin A, and 0 mug vitamin B-12) 5 d/wk for 6 mo.	Iron	12-14	arylsulfatase F	Homo sapiens	221-224
28424257-1	2017	Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8.9 mg Fe, 2.7 mg Zn, 1050 mug retinoic acid equivalent vitamin A, and 5.5 mug vitamin B-12) or a control snack (mean: 150 kcal, 2.0 mg Fe, 0.9 mg Zn, 0 mug retinoic acid equivalent vitamin A, and 0 mug vitamin B-12) 5 d/wk for 6 mo.	Iron	604-606	arylsulfatase F	Homo sapiens	221-224
28424257-5	2017	In the ASF group, intakes of iron and vitamins A and B-12 below the EAR were eliminated, and the prevalence of a low zinc intake was reduced to 9.6% compared with 64.7% in controls (P &lt; 0.001).	Iron	29-33	arylsulfatase F	Homo sapiens	7-10
28424257-6	2017	At 6 mo, a modest increase (P &lt; 0.05) in hemoglobin and iron status occurred in the ASF group compared with the control group, but plasma zinc, retinol, and serum vitamin B-12 concentrations did not differ.	Iron	59-63	arylsulfatase F	Homo sapiens	87-90
28424257-7	2017	UTI relative risk was 3.9 (P &lt; 0.05) among women assigned to the ASF group who had a low whole-body iron status at baseline.Conclusions: Adding a small amount of locally produced ASF to the diets of reproductive-age Vietnamese women improved micronutrient intakes and iron status.	Iron	103-107	arylsulfatase F	Homo sapiens	68-71
28424257-7	2017	UTI relative risk was 3.9 (P &lt; 0.05) among women assigned to the ASF group who had a low whole-body iron status at baseline.Conclusions: Adding a small amount of locally produced ASF to the diets of reproductive-age Vietnamese women improved micronutrient intakes and iron status.	Iron	103-107	arylsulfatase F	Homo sapiens	182-185
28424257-7	2017	UTI relative risk was 3.9 (P &lt; 0.05) among women assigned to the ASF group who had a low whole-body iron status at baseline.Conclusions: Adding a small amount of locally produced ASF to the diets of reproductive-age Vietnamese women improved micronutrient intakes and iron status.	Iron	271-275	arylsulfatase F	Homo sapiens	182-185
28424257-8	2017	However, the increased UTI incidence in women in the ASF group with initially lower iron stores warrants further investigation.	Iron	84-88	arylsulfatase F	Homo sapiens	53-56
27736268-2	2017	Iron complexed to transferrin is delivered to the metabolism after endocytosis via the CD71 surface receptor.	Iron	0-4	transferrin	Mus musculus	18-29
28474046-4	2017	In this review CFTR and Slo1 BKCa channels are employed to discuss the possible heme-independent interplay between iron and CO. Our recent studies demonstrated a high-affinity Fe3+ site at the interface between the regulatory domain and intracellular loop 3 of CFTR.	Iron	115-119	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	24-28
28474046-6	2017	In contrast, CO repeatedly stimulates the human Slo1 BKCa channel opening, possibly by binding to an unknown iron site, because cyanide prohibits this heme-independent CO stimulation.	Iron	109-113	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	48-52
28210838-2	2017	Neutrophil gelatinase-associated lipocalin (NGAL) is known to be upregulated within the uroepithelium and kidney of patients with UTI and exhibits a localized bacteriostatic effect through iron chelation.	Iron	189-193	lipocalin 2	Homo sapiens	0-42
28210838-2	2017	Neutrophil gelatinase-associated lipocalin (NGAL) is known to be upregulated within the uroepithelium and kidney of patients with UTI and exhibits a localized bacteriostatic effect through iron chelation.	Iron	189-193	lipocalin 2	Homo sapiens	44-48
28342790-7	2017	Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores.	Iron	66-70	lipocalin 2	Homo sapiens	177-188
28342790-7	2017	Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores.	Iron	113-117	lipocalin 2	Homo sapiens	177-188
28342790-7	2017	Recent evidence supports the existence of transferrin-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores.	Iron	113-117	lipocalin 2	Homo sapiens	177-188
28342790-9	2017	In particular, we pay attention to recent developments, pointing to lipocalin-2 and siderophores as alternative iron transport molecules in the tumor microenvironment.	Iron	112-116	lipocalin 2	Homo sapiens	68-79
28641663-0	2017	[Expression Changes of Hepcidin and Ferroportin 1 in Murine Model of Iron Overload].	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	23-31
28641663-1	2017	OBJECTIVE: To investigate the changes of hepcidin and ferropotin 1 expression in murine model of iron overload.	Iron	97-101	hepcidin antimicrobial peptide	Mus musculus	41-49
28641663-10	2017	Furthermore, serum hepcidin was increased along with increase of iron injection time (r=0.957).	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	19-27
28641663-13	2017	CONCLUSION: The expressions of hepcidin and ferroportin 1 are increase in a murine model of iron overload, which may be contributed to the suppression effect on erythropoiesis in bone marrow.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	31-39
28542246-1	2017	Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA encoding proteins involved in cellular iron metabolism.	Iron	121-125	aconitase 1	Mus musculus	0-25
28542246-1	2017	Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA encoding proteins involved in cellular iron metabolism.	Iron	121-125	aconitase 1	Mus musculus	27-31
28542246-1	2017	Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA encoding proteins involved in cellular iron metabolism.	Iron	233-237	aconitase 1	Mus musculus	0-25
28542246-1	2017	Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA encoding proteins involved in cellular iron metabolism.	Iron	233-237	aconitase 1	Mus musculus	27-31
28521769-4	2017	Here we test the hypothesis that hepcidin alone is able to regulate iron distribution in different dietary regimes in the mouse using a computational model of iron distribution calibrated with radioiron tracer data.	Iron	159-163	hepcidin antimicrobial peptide	Mus musculus	33-41
28377056-1	2017	Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	0-8
28752141-2	2017	Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage iron therapy for HD patients.	Iron	76-80	lipocalin 2	Homo sapiens	0-42
28752141-2	2017	Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage iron therapy for HD patients.	Iron	76-80	lipocalin 2	Homo sapiens	44-48
28212898-15	2017	CONCLUSION: Low levels of Fe in elderly men are associated with high levels of iFGF23, independently of markers of inflammation and renal function, suggesting an iron-related pathway for FGF23 regulation.	Iron	26-28	fibroblast growth factor 23	Homo sapiens	80-85
28212898-15	2017	CONCLUSION: Low levels of Fe in elderly men are associated with high levels of iFGF23, independently of markers of inflammation and renal function, suggesting an iron-related pathway for FGF23 regulation.	Iron	162-166	fibroblast growth factor 23	Homo sapiens	80-85
27125837-7	2017	Rs12979860 TT or rs8099917 GG genotypes as well as markers of serum and hepatocyte iron overload associated with higher activity of gamma-glutamyl transpeptidase and liver steatosis.	Iron	83-87	inactive glutathione hydrolase 2	Homo sapiens	132-161
27387517-0	2017	HAL2 overexpression induces iron acquisition in bdf1Delta cells and enhances their salt resistance.	Iron	28-32	3'(2'),5'-bisphosphate nucleotidase	Saccharomyces cerevisiae S288C	0-4
27387517-8	2017	Our results reveal that genes for iron acquisition and cellular and mitochondrial remodeling are induced by HAL2.	Iron	34-38	3'(2'),5'-bisphosphate nucleotidase	Saccharomyces cerevisiae S288C	108-112
27387517-10	2017	Mitochondrial iron-sulfur cluster (ISC) assembly also decreases in bdf1Delta + HAL2.	Iron	14-18	3'(2'),5'-bisphosphate nucleotidase	Saccharomyces cerevisiae S288C	79-83
28167288-7	2017	Quantitative real-time polymerase chain reaction demonstrated significant dysregulation of genes involved in iron and heme metabolism, including Hmox1, Fech, Abcb7, and Sf3b1 downregulation.	Iron	109-113	ferrochelatase	Mus musculus	152-156
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	26-30	poly(rC) binding protein 2	Mus musculus	80-85
28375153-3	2017	In cultured animal cells, iron chaperones poly rC-binding protein 1 (PCBP1) and PCBP2 deliver iron to ferritin, the sole cytosolic iron storage protein, and nuclear receptor coactivator 4 (NCOA4) mediates the autophagic turnover of ferritin.	Iron	94-98	poly(rC) binding protein 2	Mus musculus	80-85
28185024-1	2017	Patients with erythropoietic protoporphyria (EPP) have reduced activity of the enzyme ferrochelatase that catalyzes the insertion of iron into protoporphyrin IX (PPIX) to form heme.	Iron	133-137	ferrochelatase	Homo sapiens	86-100
28373552-4	2017	Developing Arabidopsis thaliana seedlings require the natural resistance-associated macrophage proteins (NRAMP3 and NRAMP4) transporters to remobilize iron from seed vacuolar stores and thereby acquire photosynthetic competence.	Iron	151-155	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	105-111
28373552-4	2017	Developing Arabidopsis thaliana seedlings require the natural resistance-associated macrophage proteins (NRAMP3 and NRAMP4) transporters to remobilize iron from seed vacuolar stores and thereby acquire photosynthetic competence.	Iron	151-155	natural resistance associated macrophage protein 4	Arabidopsis thaliana	116-122
28213091-5	2017	TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine.	Iron	114-116	hepcidin antimicrobial peptide	Mus musculus	54-62
28213091-5	2017	TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine.	Iron	114-116	hepcidin antimicrobial peptide	Mus musculus	64-68
28213091-5	2017	TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine.	Iron	172-174	hepcidin antimicrobial peptide	Mus musculus	54-62
28213091-5	2017	TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine.	Iron	172-174	hepcidin antimicrobial peptide	Mus musculus	64-68
28213091-5	2017	TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine.	Iron	172-174	hepcidin antimicrobial peptide	Mus musculus	54-62
28213091-5	2017	TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine.	Iron	172-174	hepcidin antimicrobial peptide	Mus musculus	64-68
28443246-2	2017	HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion.	Iron	86-90	homeostatic iron regulator	Mus musculus	0-3
28443246-2	2017	HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion.	Iron	115-119	homeostatic iron regulator	Mus musculus	0-3
28443246-2	2017	HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion.	Iron	115-119	homeostatic iron regulator	Mus musculus	0-3
28443246-6	2017	As predicted, Hfe-/- mice, a model of hereditary hemochromatosis, displayed reduced spleen iron content, which translated into improved control of Salmonella replication.	Iron	91-95	homeostatic iron regulator	Mus musculus	14-17
28443246-7	2017	Salmonella adapted to the iron-poor microenvironment in the spleens of Hfe-/- mice by inducing the expression of its siderophore iron-uptake machinery.	Iron	26-30	homeostatic iron regulator	Mus musculus	71-74
28443246-7	2017	Salmonella adapted to the iron-poor microenvironment in the spleens of Hfe-/- mice by inducing the expression of its siderophore iron-uptake machinery.	Iron	44-48	homeostatic iron regulator	Mus musculus	71-74
28443246-8	2017	Dietary iron loading resulted in higher bacterial numbers in both WT and Hfe-/- mice, although Hfe deficiency still resulted in better pathogen control and improved survival.	Iron	8-12	homeostatic iron regulator	Mus musculus	73-76
28443246-11	2017	Moreover, Hfe-associated iron overload and dietary iron excess result in different outcomes in infection, indicating that tissue and cellular iron distribution determines the susceptibility to infection with specific pathogens.	Iron	25-29	homeostatic iron regulator	Mus musculus	10-13
28103400-7	2017	In contrast, the knockout of potential Fe-S scaffold proteins, NFU2 and HCF101, resulted in a specific decrease in the PsaA/B and PsaC levels.	Iron	39-43	NIFU-like protein 2	Arabidopsis thaliana	63-67
27936457-7	2017	The combination of iron overload (Hfe-/-) and defective antioxidant defences (Nrf2-/-) increased the number of iron-related necroinflammatory lesions (sideronecrosis), possibly due to the accumulation of toxic oxidation products such as 4-hydroxy-2-nonenal-protein adducts.	Iron	19-23	homeostatic iron regulator	Mus musculus	34-41
27936457-7	2017	The combination of iron overload (Hfe-/-) and defective antioxidant defences (Nrf2-/-) increased the number of iron-related necroinflammatory lesions (sideronecrosis), possibly due to the accumulation of toxic oxidation products such as 4-hydroxy-2-nonenal-protein adducts.	Iron	111-115	homeostatic iron regulator	Mus musculus	34-41
28202542-10	2017	HFE-/- livers were overloaded with ferritin but had low mitochondrial iron levels.	Iron	70-74	homeostatic iron regulator	Mus musculus	0-3
28202542-11	2017	IRP2-/- hearts contained less ferritin than controls but normal levels of mitochondrial iron.	Iron	88-92	iron responsive element binding protein 2	Mus musculus	0-4
28270217-0	2017	DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.	Iron	68-72	cytochrome b reductase 1	Homo sapiens	0-5
28270217-1	2017	BACKGROUND: Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum.	Iron	146-150	cytochrome b reductase 1	Homo sapiens	12-33
28270217-1	2017	BACKGROUND: Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum.	Iron	146-150	cytochrome b reductase 1	Homo sapiens	35-40
28357393-0	2017	Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae.	Iron	35-39	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	18-22
28357393-4	2017	We now show that the yeast high-affinity iron transporter Ftr1 and high-affinity zinc transporter Zrt1 function as transceptors for the micronutrients iron and zinc.	Iron	41-45	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	58-62
28357393-6	2017	The activation with iron is dependent on Ftr1 and with zinc on Zrt1, and we show that it is independent of intracellular iron and zinc levels.	Iron	20-24	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	41-45
28357393-7	2017	Similar to the transceptors for macronutrients, Ftr1 and Zrt1 are strongly induced upon iron and zinc starvation, respectively, and they are rapidly downregulated by substrate-induced endocytosis.	Iron	88-92	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	48-52
27826644-4	2017	FGF23 may be implicated in iron metabolism and erythropoiesis, inflammation, insulin resistance, proteinuria, acute kidney injury and left ventricular hypertrophy.	Iron	27-31	fibroblast growth factor 23	Homo sapiens	0-5
27890768-1	2017	BACKGROUND &amp; AIMS: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid production, which can inhibit iron absorption.	Iron	150-154	ATPase H+/K+ transporting subunit alpha	Homo sapiens	23-34
28369511-0	2017	bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana.	Iron	44-48	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	26-33
28369511-10	2017	Thus, bHLH115 plays key roles in the maintenance of Fe homeostasis in Arabidopsis thaliana.	Iron	52-54	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	6-13
28216614-0	2017	Infection: IL-22 controls iron scavenging.	Iron	26-30	interleukin 22	Homo sapiens	11-16
27240439-6	2017	In this study, we have taken advantage of the fluorescent-tagged protein GFP-OsVIT1, which functionally complements the Fe hypersensitivity of ccc1 yeast mutant, to generate transgenic Arabidopsis suspension cell lines and plants.	Iron	120-122	Ccc1p	Saccharomyces cerevisiae S288C	143-147
27839945-7	2017	Independently, the murine homolog Btbd9 was identified as a candidate gene for iron regulation in the midbrain in mice.	Iron	79-83	BTB (POZ) domain containing 9	Mus musculus	34-39
27839945-9	2017	The role of Btbd9 in iron regulation and RLS-like behaviors has been further evaluated in mice carrying a null mutation of the gene and in fruit flies when the BTBD9 protein is degraded.	Iron	21-25	BTB (POZ) domain containing 9	Mus musculus	12-17
28223461-10	2017	Furthermore, differential expression of more than 90 genes was detected, including the small regulatory RNA prrF1, which contributes to a global iron-sparing response via the repression of a set of gene targets.	Iron	145-149	prrF1	Pseudomonas aeruginosa PAO1	108-113
28228829-11	2017	Hepatic Hamp mRNA levels were lower in the HFD and higher in the CR groups compared with the Control group, which could be a response to maintain iron homeostasis.	Iron	146-150	hepcidin antimicrobial peptide	Mus musculus	8-12
28187176-9	2017	Iron chelation abolishes the effect of alpha-synuclein on neuronal cell beta-amyloid secretion, whereas overexpression of the ferrireductase enzyme Steap3 is robustly pro-amyloidogenic.	Iron	0-4	synuclein alpha	Rattus norvegicus	39-54
28178521-3	2017	By doing so, they form a docking site for Fe-S proteins that is disrupted in the absence of either MMS19 or MIP18.	Iron	42-46	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	99-104
28007574-4	2017	Our results suggest that Slt2 form iron/sulphur bridged clusters with Grx3 and Grx4.	Iron	35-39	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	70-74
28010050-7	2017	RBC transfusion was associated with a higher Hb on day 1, inhibition of reticulocytosis during the first week and low iron levels.	Iron	118-122	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	0-3
28135344-2	2017	The amount of iron in the plasma, and hence its availability for hemoglobin synthesis, is determined by the liver-derived iron regulatory hormone hepcidin.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	146-154
28135344-3	2017	When the iron supply to erythroid precursors is limited, as often occurs during stimulated erythropoiesis, these cells produce signals to inhibit hepatic hepcidin production, thereby increasing the amount of iron that enters the plasma.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	154-162
28135344-3	2017	When the iron supply to erythroid precursors is limited, as often occurs during stimulated erythropoiesis, these cells produce signals to inhibit hepatic hepcidin production, thereby increasing the amount of iron that enters the plasma.	Iron	208-212	hepcidin antimicrobial peptide	Mus musculus	154-162
27864295-1	2017	Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance.	Iron	152-156	hepcidin antimicrobial peptide	Mus musculus	120-128
27864295-9	2017	Together, these data demonstrate that ECs are the predominant source of BMP6 in the liver and support a model in which EC BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin transcription and maintain systemic iron homeostasis.	Iron	232-236	hemojuvelin BMP co-receptor	Mus musculus	163-174
27903529-7	2017	Iron overload was mediated by decreased hepatic expression of hepcidin, a key regulator of iron homeostasis.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	62-70
27903529-7	2017	Iron overload was mediated by decreased hepatic expression of hepcidin, a key regulator of iron homeostasis.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	62-70
28001042-0	2017	Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.	Iron	120-124	ferredoxin 1	Homo sapiens	20-32
28001042-0	2017	Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.	Iron	120-124	ferredoxin 1	Homo sapiens	34-38
28001042-9	2017	In an in vitro reaction, the reduced form of each ferredoxin was found to support Fe-S cluster assembly on ISCU; the rate of cluster assembly was faster with FDX2 than with FDX1.	Iron	82-86	ferredoxin 1	Homo sapiens	173-177
28001042-10	2017	Taken together, these results show that both FDX1 and FDX2 can function in Fe-S cluster assembly in vitro.	Iron	75-79	ferredoxin 1	Homo sapiens	45-49
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	cytochrome b reductase 1	Homo sapiens	200-206
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	hephaestin	Homo sapiens	222-226
28031527-5	2017	Importantly, we have identified specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response (ABCB10, ACO1, CYBRD1, EPAS1, GLRX5, HEPH, HFE, IREB2, QSOX1 and TFRC).	Iron	67-71	quiescin sulfhydryl oxidase 1	Homo sapiens	240-245
28138322-4	2017	Furthermore, iron loading significantly downregulated Beclin-1 levels and decreased the ratio of microtubule-associated protein 1 light chain 3 isoforms (LC3 II/LC3 I).	Iron	13-17	beclin 1	Homo sapiens	54-62
28255266-0	2017	Lipocalin-2 Promotes Endoplasmic Reticulum Stress and Proliferation by Augmenting Intracellular Iron in Human Pulmonary Arterial Smooth Muscle Cells.	Iron	96-100	lipocalin 2	Homo sapiens	0-11
28255266-2	2017	Increased expression of Lipocalin-2 in PH led us to test the hypothesis that Lipocalin-2, a protein known to sequester iron and regulate it intracellularly, might facilitate the ER stress and proliferation in pulmonary arterial smooth muscle cells (PASMCs).	Iron	119-123	lipocalin 2	Homo sapiens	77-88
28255266-5	2017	Lcn2 promoted ER stress accompanied with augmented intracellular iron levels in human PASMCs.	Iron	65-69	lipocalin 2	Homo sapiens	0-4
28255266-6	2017	Treatment human PASMCs with FeSO4 induced the similar ER stress and proliferation response and iron chelator (deferoxamine) abrogated the ER stress and proliferation induced by Lcn2 in cultured human PASMCs.	Iron	95-99	lipocalin 2	Homo sapiens	177-181
28255266-7	2017	In conclusion, Lcn2 significantly promoted human PASMC ER stress and proliferation by augmenting intracellular iron.	Iron	111-115	lipocalin 2	Homo sapiens	15-19
28079179-9	2017	The clustering of co-expressed genes and network analysis revealed that many iron and zinc homeostasis genes are targets of transcription factors Aft1p and Zap1p.	Iron	77-81	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	146-151
28079179-9	2017	The clustering of co-expressed genes and network analysis revealed that many iron and zinc homeostasis genes are targets of transcription factors Aft1p and Zap1p.	Iron	77-81	Zap1p	Saccharomyces cerevisiae S288C	156-161
29225212-4	2017	In this study, we found that treatment of cells with an iron-specific chelator deferoxamine (DFO) increased reactive oxidative species (ROS) production by elevating the expression of p47phox and p67phox compared with that in untreated cells.	Iron	56-60	neutrophil cytosolic factor 1	Homo sapiens	183-190
28540293-3	2017	Tfr2alpha is one of the hepatic regulators of iron inhibitor hepcidin.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	61-69
29145194-0	2017	Deficiency of Functional Iron-Sulfur Domains in ABCE1 Inhibits the Proliferation and Migration of Lung Adenocarcinomas By Regulating the Biogenesis of Beta-Actin In Vitro.	Iron	25-29	ATP binding cassette subfamily E member 1	Homo sapiens	48-53
29145194-0	2017	Deficiency of Functional Iron-Sulfur Domains in ABCE1 Inhibits the Proliferation and Migration of Lung Adenocarcinomas By Regulating the Biogenesis of Beta-Actin In Vitro.	Iron	25-29	POTE ankyrin domain family member F	Homo sapiens	151-161
29145194-1	2017	BACKGROUND/AIMS: ATP-binding cassette transporter E1 (ABCE1), a unique ABC superfamily member that bears two Fe-S clusters, is essential for metastatic progression in lung cancer.	Iron	109-113	ATP binding cassette subfamily E member 1	Homo sapiens	17-52
29145194-1	2017	BACKGROUND/AIMS: ATP-binding cassette transporter E1 (ABCE1), a unique ABC superfamily member that bears two Fe-S clusters, is essential for metastatic progression in lung cancer.	Iron	109-113	ATP binding cassette subfamily E member 1	Homo sapiens	54-59
29145194-2	2017	Fe-S clusters within ABCE1 are crucial for ribosome dissociation and translation reinitiation; however, whether these clusters promote tumor proliferation and migration is unclear.	Iron	0-4	ATP binding cassette subfamily E member 1	Homo sapiens	21-26
29145194-7	2017	RESULTS: Fe-S clusters were the key domains in ABCE1 involved in binding to beta-actin.	Iron	9-13	ATP binding cassette subfamily E member 1	Homo sapiens	47-52
29145194-7	2017	RESULTS: Fe-S clusters were the key domains in ABCE1 involved in binding to beta-actin.	Iron	9-13	POTE ankyrin domain family member F	Homo sapiens	76-86
29145194-12	2017	CONCLUSION: These results demonstrate the indispensable role of Fe-S clusters when ABCE1 participates in the proliferation and migration of LUADs by interacting with beta-actin.	Iron	64-68	ATP binding cassette subfamily E member 1	Homo sapiens	83-88
29145194-12	2017	CONCLUSION: These results demonstrate the indispensable role of Fe-S clusters when ABCE1 participates in the proliferation and migration of LUADs by interacting with beta-actin.	Iron	64-68	POTE ankyrin domain family member F	Homo sapiens	166-176
29145194-13	2017	The Fe-S clusters of ABCE1 may be potential targets for the prevention of lung cancer metastasis.	Iron	4-8	ATP binding cassette subfamily E member 1	Homo sapiens	21-26
28034630-7	2017	Intriguingly, the pol3-13 mutation that affects the Fe-S cluster in the CTD of the catalytic subunit of pol delta also leads to defective induced mutagenesis, suggesting the possibility that Fe-S clusters are essential for the pol switches during replication of damaged DNA.	Iron	52-56	DNA-directed DNA polymerase delta POL3	Saccharomyces cerevisiae S288C	18-22
28034630-7	2017	Intriguingly, the pol3-13 mutation that affects the Fe-S cluster in the CTD of the catalytic subunit of pol delta also leads to defective induced mutagenesis, suggesting the possibility that Fe-S clusters are essential for the pol switches during replication of damaged DNA.	Iron	191-195	DNA-directed DNA polymerase delta POL3	Saccharomyces cerevisiae S288C	18-22
28286378-0	2017	Iron Reduces M1 Macrophage Polarization in RAW264.7 Macrophages Associated with Inhibition of STAT1.	Iron	0-4	signal transducer and activator of transcription 1	Homo sapiens	94-99
28286378-9	2017	Moreover, we demonstrated that STAT1 inhibition was required for reduction of iNOS and M1-related cytokines production by the present of iron.	Iron	137-141	signal transducer and activator of transcription 1	Homo sapiens	31-36
27801584-0	2016	Human Ferrochelatase: Insights for the Mechanism of Ferrous Iron Approaching Protoporphyrin IX by QM/MM and QTCP Free Energy Studies.	Iron	60-64	ferrochelatase	Homo sapiens	6-20
27801584-1	2016	Ferrochelatase catalyzes the insertion of ferrous iron into protoporphyrin IX, the terminal step in heme biosynthesis.	Iron	42-54	ferrochelatase	Homo sapiens	0-14
28000736-4	2016	Though evolved independently, two strains carried shared mutations: amplification of the xylose isomerase gene and inactivation of ISU1, a gene encoding a scaffold protein involved in the assembly of iron-sulfur clusters.	Iron	200-204	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	131-135
27928027-3	2016	Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues.	Iron	51-55	neuroglobin	Homo sapiens	0-3
27627839-1	2016	In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2+ into protoporphyrin IX.	Iron	57-61	ferrochelatase	Homo sapiens	88-102
27627839-2	2016	However, the path of iron from endosomes to mitochondrial ferrochelatase remains elusive.	Iron	21-25	ferrochelatase	Homo sapiens	58-72
27627839-4	2016	In contrast, this study supports the hypothesis that the highly efficient transport of iron toward ferrochelatase in erythroid cells requires a direct interaction between transferrin-endosomes and mitochondria (the "kiss-and-run" hypothesis).	Iron	87-91	ferrochelatase	Homo sapiens	99-113
27580520-2	2016	GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF.	Iron	13-17	CD163 molecule	Homo sapiens	28-33
27580520-2	2016	GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF.	Iron	92-96	CD163 molecule	Homo sapiens	28-33
27825668-4	2016	In response, host immune cells secrete lipocalin 2 (also known as siderocalin), a siderophore-binding protein, to prevent bacterial reuptake of iron-loaded siderophores.	Iron	144-148	lipocalin 2	Homo sapiens	39-50
27682429-4	2016	In contrast, such counterions as I5 , I3 , BF4 , SbF6 , and PF6 are found to be tightly associated with one of the porphyrin rings and, therefore, stabilize two different spin states of iron in one molecule.	Iron	186-190	spindlin 1	Homo sapiens	171-175
27682429-5	2016	A spectroscopic investigation of 2 TNP has revealed the presence of two equivalent iron centers with a high-spin state (S=5/2) in the solid state that converts to intermediate spin (S=3/2) in solution.	Iron	83-87	spindlin 1	Homo sapiens	108-112
27682429-5	2016	A spectroscopic investigation of 2 TNP has revealed the presence of two equivalent iron centers with a high-spin state (S=5/2) in the solid state that converts to intermediate spin (S=3/2) in solution.	Iron	83-87	spindlin 1	Homo sapiens	176-180
28203489-0	2016	Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts.	Iron	90-94	hemojuvelin BMP co-receptor	Mus musculus	47-51
28203489-1	2016	OBJECTIVE: Hepcidin is a peptide hormone produced by the liver that regulates systemic iron homeostasis.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	11-19
28203489-2	2016	Hepcidin is also synthesized by tumors, where it contributes to tumor growth by increasing the tumoral retention of iron.	Iron	116-120	hepcidin antimicrobial peptide	Mus musculus	0-8
28203489-12	2016	CONCLUSION: Anti-hemojuvelin antibody successfully reduces hepcidin in both tumors and livers but has different effects in these target organs: it reduces iron content and ferritin in the liver, but does not reduce iron content or ferritin in tumors, and does not inhibit tumor growth.	Iron	155-159	hemojuvelin BMP co-receptor	Mus musculus	17-28
27792144-7	2016	In addition, the expression of some Fe acquisition-related genes, including FIT1, FRO2, and IRT1 were significantly up-regulated by melatonin treatments, whereas the enhanced expression of these genes was obviously suppressed in the polyamine- and NO-deficient plants.	Iron	36-38	iron-regulated transporter 1	Arabidopsis thaliana	92-96
27658969-4	2016	Combined with the first-principle calculations, the results suggest that the bonding with Fe and Ga or As ions and the ionic distortion near the interface, as well as the FeO defects and oxygen vacancies, may increase the spin-orbit coupling in ultrathin Fe3O4 epitaxial films and in turn provide an enhanced damping.	Iron	90-92	spindlin 1	Homo sapiens	222-226
27632358-0	2016	Coupling of Coexisting Noncollinear Spin States in the Fe Monolayer on Re(0001).	Iron	55-57	spindlin 1	Homo sapiens	36-40
27632358-1	2016	Spin-polarized scanning tunneling microscopy is used to investigate the magnetic state of the Fe monolayer on Re(0001).	Iron	94-96	spindlin 1	Homo sapiens	0-4
27761236-8	2016	In this article, we review the brain iron deposition of PD, MSA-P and PSP in SWI in the hope of exhibiting a profile of SWI features in PD, MSA and PSP and its clinical values.	Iron	37-41	microseminoprotein beta	Homo sapiens	70-73
27761236-8	2016	In this article, we review the brain iron deposition of PD, MSA-P and PSP in SWI in the hope of exhibiting a profile of SWI features in PD, MSA and PSP and its clinical values.	Iron	37-41	microseminoprotein beta	Homo sapiens	148-151
27711215-1	2016	Hepcidin is the key regulator of systemic iron availability that acts by controlling the degradation of the iron exporter ferroportin.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	0-8
27711215-1	2016	Hepcidin is the key regulator of systemic iron availability that acts by controlling the degradation of the iron exporter ferroportin.	Iron	108-112	hepcidin antimicrobial peptide	Mus musculus	0-8
27555240-2	2016	Spectroscopic characterization has revealed that the iron centers of the bischloro and mu-oxo complexes are in the high-spin state (S=(5) /2 ).	Iron	53-57	spindlin 1	Homo sapiens	120-124
27555240-3	2016	However, the two iron centers in the diiron(III) mu-hydroxo complexes are equivalent with high spin (S=(5) /2 ) in the solid state and an intermediate-spin state (S=(3) /2 ) in solution.	Iron	17-21	spindlin 1	Homo sapiens	95-99
27555240-3	2016	However, the two iron centers in the diiron(III) mu-hydroxo complexes are equivalent with high spin (S=(5) /2 ) in the solid state and an intermediate-spin state (S=(3) /2 ) in solution.	Iron	17-21	spindlin 1	Homo sapiens	151-155
27576776-8	2016	Using parabiosis ICH models also shows that increased serum hepcidin prevents brain iron efflux.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	60-68
27576776-10	2016	TLR4-/- and MyD88-/- mice exhibited improvement in brain iron efflux at 7, 14, and 28 days after ICH, and the TLR4 antagonist (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate significantly decreased brain iron levels at days 14 and 28 after ICH and improved cognition impairment at day 28.	Iron	57-61	myeloid differentiation primary response gene 88	Mus musculus	12-17
27576776-11	2016	CONCLUSIONS: The results presented here show that increased hepcidin expression caused by inflammation prevents brain iron efflux via inhibition of the intracellular iron efflux of brain microvascular endothelial cells entering into circulation and aggravating oxidative brain injury and cognition impairment, which identifies a mechanistic target for muting inflammation to promote brain iron efflux and to attenuate oxidative brain injury after ICH.	Iron	118-122	hepcidin antimicrobial peptide	Mus musculus	60-68
27576776-11	2016	CONCLUSIONS: The results presented here show that increased hepcidin expression caused by inflammation prevents brain iron efflux via inhibition of the intracellular iron efflux of brain microvascular endothelial cells entering into circulation and aggravating oxidative brain injury and cognition impairment, which identifies a mechanistic target for muting inflammation to promote brain iron efflux and to attenuate oxidative brain injury after ICH.	Iron	166-170	hepcidin antimicrobial peptide	Mus musculus	60-68
27576776-11	2016	CONCLUSIONS: The results presented here show that increased hepcidin expression caused by inflammation prevents brain iron efflux via inhibition of the intracellular iron efflux of brain microvascular endothelial cells entering into circulation and aggravating oxidative brain injury and cognition impairment, which identifies a mechanistic target for muting inflammation to promote brain iron efflux and to attenuate oxidative brain injury after ICH.	Iron	166-170	hepcidin antimicrobial peptide	Mus musculus	60-68
27589831-0	2016	Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis.	Iron	15-19	kinase insert domain receptor	Homo sapiens	29-74
27589831-12	2016	In conclusion, our studies show that cell-permeable iron attenuates VEGFR-2 mediated signaling and inhibits tumor angiogenesis.	Iron	52-56	kinase insert domain receptor	Homo sapiens	68-75
27410488-0	2016	Hepcidin independent iron recycling in a mouse model of beta-thalassaemia intermedia.	Iron	21-25	hepcidin antimicrobial peptide	Mus musculus	0-8
27410488-1	2016	In conditions such as beta-thalassaemia, stimulated erythropoiesis can reduce the expression of the iron regulatory hormone hepcidin, increasing both macrophage iron release and intestinal iron absorption and leading to iron loading.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	124-132
27483343-1	2016	Hepcidin, the iron hormone, is regulated by a number of stimulatory and inhibitory signals.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	0-8
27483343-3	2016	In this study we asked whether hepcidin response to ER stress also requires the small mother against decapentaplegic (SMAD)-1/5/8 pathway, which has a major role in hepcidin regulation in response to iron and other stimuli.	Iron	200-204	hepcidin antimicrobial peptide	Mus musculus	31-39
27483343-3	2016	In this study we asked whether hepcidin response to ER stress also requires the small mother against decapentaplegic (SMAD)-1/5/8 pathway, which has a major role in hepcidin regulation in response to iron and other stimuli.	Iron	200-204	hepcidin antimicrobial peptide	Mus musculus	165-173
27434063-0	2016	High-Spin Iron(I) and Iron(0) Dinitrogen Complexes Supported by N-Heterocyclic Carbene Ligands.	Iron	10-14	spindlin 1	Homo sapiens	5-9
27557498-5	2016	We used gene expression data derived from a genetically defined model of Ewing sarcoma to interrogate the Connectivity Map and identify a class of drugs, iron chelators, that downregulate a significant number of EWS-FLI1 target genes.	Iron	154-158	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	216-220
27403880-8	2016	The results showed that iron-overload induced BBB breakdown, brain iron accumulation, brain mitochondrial dysfunction, impaired brain mitochondrial dynamics, tau-hyperphosphorylation, Abeta accumulation and dendritic spine reduction.	Iron	24-28	amyloid beta precursor protein	Rattus norvegicus	184-189
27646472-10	2016	Overexpression of Kir6.2/SUR1 resulted in an increase in iron influx and intracellular iron levels, which was markedly increased after diazoxide treatment.	Iron	57-61	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	18-24
27646472-10	2016	Overexpression of Kir6.2/SUR1 resulted in an increase in iron influx and intracellular iron levels, which was markedly increased after diazoxide treatment.	Iron	87-91	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	18-24
27445333-7	2016	Moreover, ribosomal inactivation-induced iron accumulation in Caenorhabditis elegans as a simplified in vivo model for gut nutrition uptake was dependent on SEK-1, a p38 kinase activator, leading to suppression of FPN-1.1 expression and iron accumulation.	Iron	41-45	Solute carrier family 40 protein	Caenorhabditis elegans	214-221
27615691-0	2016	Spin excitations in hole-overdoped iron-based superconductors.	Iron	35-39	spindlin 1	Homo sapiens	0-4
27615691-4	2016	Here we report a study on the spin fluctuations of the hole-overdoped iron-based superconductors Ba1-xKxFe2As2 (x = 0.5 and 1.0; Tc = 36 K and 3.4 K, respectively) over the entire Brillouin zone using inelastic neutron scattering.	Iron	70-74	spindlin 1	Homo sapiens	30-34
28573162-0	2016	Measurement of Transferrin- and Non-transferrin-bound Iron Uptake by Mouse Tissues.	Iron	54-58	transferrin	Mus musculus	36-47
28573162-1	2016	Iron in blood plasma is bound to its transport protein transferrin, which delivers iron to most tissues.	Iron	0-4	transferrin	Mus musculus	55-66
28573162-1	2016	Iron in blood plasma is bound to its transport protein transferrin, which delivers iron to most tissues.	Iron	83-87	transferrin	Mus musculus	55-66
28573162-2	2016	In iron overload and certain pathological conditions, the carrying capacity of transferrin can become exceeded, giving rise to non-transferrin-bound iron, which is taken up preferentially by the liver, kidney, pancreas, and heart.	Iron	3-7	transferrin	Mus musculus	79-90
28573162-2	2016	In iron overload and certain pathological conditions, the carrying capacity of transferrin can become exceeded, giving rise to non-transferrin-bound iron, which is taken up preferentially by the liver, kidney, pancreas, and heart.	Iron	149-153	transferrin	Mus musculus	79-90
28573162-2	2016	In iron overload and certain pathological conditions, the carrying capacity of transferrin can become exceeded, giving rise to non-transferrin-bound iron, which is taken up preferentially by the liver, kidney, pancreas, and heart.	Iron	149-153	transferrin	Mus musculus	131-142
28573162-3	2016	The measurement of tissue transferrin- and non-transferrin-bound iron (TBI and NTBI, respectively) uptake in vivo can be achieved via intravenous administration of 59Fe-labeled TBI or NTBI followed by gamma counting of various organs.	Iron	65-69	transferrin	Mus musculus	26-37
28573162-3	2016	The measurement of tissue transferrin- and non-transferrin-bound iron (TBI and NTBI, respectively) uptake in vivo can be achieved via intravenous administration of 59Fe-labeled TBI or NTBI followed by gamma counting of various organs.	Iron	65-69	transferrin	Mus musculus	47-58
27383256-0	2016	Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.	Iron	0-4	RAB7A, member RAS oncogene family	Homo sapiens	93-98
27383256-7	2016	Cell death triggered by altered intralysosomal iron handling is abrogated in the presence of an NAADP antagonist or when inhibiting RAB7A activity.	Iron	47-51	RAB7A, member RAS oncogene family	Homo sapiens	132-137
27383256-8	2016	Taken together, our results suggest that increased endolysosomal iron causes cell death associated with increased cytosolic oxidative stress as well as autophagic impairments, and these effects are subject to modulation by endolysosomal ion channel activity in a RAB7A-dependent manner.	Iron	65-69	RAB7A, member RAS oncogene family	Homo sapiens	263-268
27450694-2	2016	Iron is essential for the normal functioning of thyroid peroxidase (TPO-abs) and ID is frequent during pregnancy.	Iron	0-4	thyroid peroxidase	Homo sapiens	68-71
27399352-11	2016	Upon structural analysis, near-identical folds, protein contact areas, and orientations of heme/iron-sulfur cluster suggested that both mutations may destabilize the CYP27B1-FDX1 complex by negating directional interactions with adrenodoxin.	Iron	96-100	ferredoxin 1	Homo sapiens	174-178
27331785-1	2016	The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis.	Iron	51-55	RoBo-1	Rattus norvegicus	4-32
27331785-1	2016	The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis.	Iron	51-55	RoBo-1	Rattus norvegicus	34-38
27331785-14	2016	Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress.	Iron	0-4	RoBo-1	Rattus norvegicus	36-64
27331785-14	2016	Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress.	Iron	0-4	RoBo-1	Rattus norvegicus	66-70
27331785-14	2016	Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress.	Iron	86-90	RoBo-1	Rattus norvegicus	36-64
27331785-14	2016	Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress.	Iron	86-90	RoBo-1	Rattus norvegicus	66-70
27427385-4	2016	Instead, we show that 2HG production perturbs the iron sensing mechanisms as indicated by upregulation of the Aft1-controlled iron regulon and a concomitant increase in iron levels.	Iron	50-54	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	110-114
27427385-4	2016	Instead, we show that 2HG production perturbs the iron sensing mechanisms as indicated by upregulation of the Aft1-controlled iron regulon and a concomitant increase in iron levels.	Iron	126-130	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	110-114
27427385-4	2016	Instead, we show that 2HG production perturbs the iron sensing mechanisms as indicated by upregulation of the Aft1-controlled iron regulon and a concomitant increase in iron levels.	Iron	126-130	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	110-114
27427385-5	2016	Accordingly, iron chelation, or overexpression of a truncated AFT1 allele that dampens transcription of the iron regulon, suppresses the loss of respirative capacity.	Iron	108-112	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	62-66
27128204-4	2016	Using laser ablation in water, the solution of Fe species is dropped on Au-S-CD, where mass peaks at 1227 m/z, 1243 m/z, and 1260 m/z are observed and assigned to C42 H68 O34 SNa-Fe(+) , C42 H68 O34 SK-Fe(+) together with C42 H68 O34 SNa-FeO(+) , and C42 H68 O34 SK-FeO(+) , respectively.	Iron	47-49	CDK5 regulatory subunit associated protein 1	Homo sapiens	163-166
27128204-4	2016	Using laser ablation in water, the solution of Fe species is dropped on Au-S-CD, where mass peaks at 1227 m/z, 1243 m/z, and 1260 m/z are observed and assigned to C42 H68 O34 SNa-Fe(+) , C42 H68 O34 SK-Fe(+) together with C42 H68 O34 SNa-FeO(+) , and C42 H68 O34 SK-FeO(+) , respectively.	Iron	47-49	CDK5 regulatory subunit associated protein 1	Homo sapiens	187-190
27128204-4	2016	Using laser ablation in water, the solution of Fe species is dropped on Au-S-CD, where mass peaks at 1227 m/z, 1243 m/z, and 1260 m/z are observed and assigned to C42 H68 O34 SNa-Fe(+) , C42 H68 O34 SK-Fe(+) together with C42 H68 O34 SNa-FeO(+) , and C42 H68 O34 SK-FeO(+) , respectively.	Iron	47-49	CDK5 regulatory subunit associated protein 1	Homo sapiens	187-190
27128204-4	2016	Using laser ablation in water, the solution of Fe species is dropped on Au-S-CD, where mass peaks at 1227 m/z, 1243 m/z, and 1260 m/z are observed and assigned to C42 H68 O34 SNa-Fe(+) , C42 H68 O34 SK-Fe(+) together with C42 H68 O34 SNa-FeO(+) , and C42 H68 O34 SK-FeO(+) , respectively.	Iron	47-49	CDK5 regulatory subunit associated protein 1	Homo sapiens	187-190
27169626-2	2016	Regulation of iron metabolism is mediated by the iron-regulatory hormone hepcidin.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	73-81
27169626-3	2016	Hepcidin limits the amount of iron released into the blood by binding to and causing the internalization of the iron exporter, ferroportin.	Iron	30-34	hepcidin antimicrobial peptide	Mus musculus	0-8
27169626-3	2016	Hepcidin limits the amount of iron released into the blood by binding to and causing the internalization of the iron exporter, ferroportin.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	0-8
27169626-5	2016	An increase in erythropoietic demand decreases hepcidin, resulting in increased bioavailable iron in the blood.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	47-55
27169626-6	2016	Transferrin receptor 2 (TFR2) is involved in the systemic regulation of iron metabolism.	Iron	72-76	transferrin receptor 2	Mus musculus	0-22
27169626-6	2016	Transferrin receptor 2 (TFR2) is involved in the systemic regulation of iron metabolism.	Iron	72-76	transferrin receptor 2	Mus musculus	24-28
27169626-7	2016	Patients and mice with mutations in TFR2 develop hemochromatosis due to inappropriate hepcidin levels relative to body iron.	Iron	119-123	transferrin receptor 2	Mus musculus	36-40
27169626-8	2016	Recent studies from our laboratory and others have suggested an additional role for TFR2 in response to iron-restricted erythropoiesis.	Iron	104-108	transferrin receptor 2	Mus musculus	84-88
27169626-9	2016	These studies used mouse models with perturbed systemic iron metabolism: anemic mice lacking matriptase-2 and Tfr2, or bone marrow transplants from iron-loaded Tfr2 null mice.	Iron	148-152	transferrin receptor 2	Mus musculus	160-164
27251223-1	2016	PROBLEM: Neutrophil gelatinase-associated lipocalin (NGAL) is expressed in neutrophils and involved in innate immunity by sequestering iron.	Iron	135-139	lipocalin 2	Homo sapiens	9-51
27251223-1	2016	PROBLEM: Neutrophil gelatinase-associated lipocalin (NGAL) is expressed in neutrophils and involved in innate immunity by sequestering iron.	Iron	135-139	lipocalin 2	Homo sapiens	53-57
26514573-2	2016	In the present study, iron-oxide-modified bentonite (Fe-PILB) was prepared and investigated as a possible adsorbent for the removal of organic matter (OM) like humic acid (HA), chromium (Cr(III)), and zinc (Zn(II)) from IPA aqueous solutions.	Iron	53-55	methionine sulfoxide reductase B2	Homo sapiens	56-60
26514573-9	2016	From the adsorption of heavy metals and OM complex compounds contained in IPA 54 % on Fe-PILB, the bridging of humic acid between bentonite and heavy metals (Zn(II) or Cr(III)) is proposed as the dominant adsorption mechanism (bentonite-HA-Me).	Iron	86-88	methionine sulfoxide reductase B2	Homo sapiens	89-93
27473977-7	2016	It was also noted that application of chelated iron can increase production of T CD8(+) cytotoxic cells and IL-2, which promotes the body"s natural response to developing inflammation.	Iron	47-51	CD8a molecule	Gallus gallus	81-84
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	53-57	transferrin receptor 2	Mus musculus	4-26
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	53-57	transferrin receptor 2	Mus musculus	28-32
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	110-118
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	110-114
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	53-57	transferrin receptor 2	Mus musculus	130-134
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	transferrin receptor 2	Mus musculus	4-26
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	transferrin receptor 2	Mus musculus	28-32
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	110-118
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	110-114
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	transferrin receptor 2	Mus musculus	4-26
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	transferrin receptor 2	Mus musculus	28-32
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	110-118
27477597-1	2016	The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of iron regulator Hepcidin (Hepc) and Tfr2 inactivation causes systemic iron overload.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	110-114
27477597-3	2016	Tfr2 abrogation caused an accumulation of iron in specific districts in the nervous tissue that was not accompanied by a brain Hepc response.	Iron	42-46	transferrin receptor 2	Mus musculus	0-4
27233600-1	2016	Iron overload, as a risk factor for osteoporosis, can result in the up-regulation of Hepcidin, and Hepcidin knockout mice display defects in their bone microarchitecture.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	85-93
27233600-1	2016	Iron overload, as a risk factor for osteoporosis, can result in the up-regulation of Hepcidin, and Hepcidin knockout mice display defects in their bone microarchitecture.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	99-107
27233600-3	2016	Here, we show that hepcidin knockdown in zebrafish using morpholinos leads to iron overload.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	19-27
27233600-7	2016	Most importantly, we revealed that hepcidin was capable of removing whole-body iron which facilitated larval recovery from the reductions in bone formation and osteogenesis induced by iron overload.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	35-43
27233600-7	2016	Most importantly, we revealed that hepcidin was capable of removing whole-body iron which facilitated larval recovery from the reductions in bone formation and osteogenesis induced by iron overload.	Iron	184-188	hepcidin antimicrobial peptide	Mus musculus	35-43
27326892-0	2016	The cotyledon cell wall and intracellular matrix are factors that limit iron bioavailability of the common bean (Phaseolus vulgaris).	Iron	72-76	brain expressed associated with NEDD4 1	Homo sapiens	107-111
27326892-1	2016	Strategies that enhance the Fe bioavailability of the bean are of keen interest to nutritionists, bean breeders and growers.	Iron	28-30	brain expressed associated with NEDD4 1	Homo sapiens	54-58
27326892-1	2016	Strategies that enhance the Fe bioavailability of the bean are of keen interest to nutritionists, bean breeders and growers.	Iron	28-30	brain expressed associated with NEDD4 1	Homo sapiens	98-102
27326892-6	2016	The iron bioavailability of cooked bean samples was assessed using an in vitro digestion/Caco-2 cell culture model.	Iron	4-8	brain expressed associated with NEDD4 1	Homo sapiens	35-39
27326892-7	2016	Microscopy analyses confirmed that the cotyledon cell walls are highly resistant to pepsin, the low pH of the stomach, and the pancreatic enzymes, indicating that the walls are a barrier to Fe absorption from the bean.	Iron	190-192	brain expressed associated with NEDD4 1	Homo sapiens	213-217
27327861-3	2016	The Fe-bearing materials also effectively activated persulfate to enhance the oxidative transformation of TNT and RDX in soil-water systems.	Iron	4-6	radixin	Homo sapiens	114-117
29964470-0	2016	[Removal of AOX, Chroma and TOC in Chemical Dyestuff Wastewater with Iron Scraps-Fenton-Coagulation Combined Process].	Iron	69-73	acyl-CoA oxidase 1	Homo sapiens	12-15
29964470-3	2016	The results showed that the removal ratios of AOX, chroma and TOC firstly increased and then decreased with the decrease of the molar ratio of Fe2+ to H2O2, while continuously increased with the increase of iron scraps and Fenton reaction time.	Iron	207-211	acyl-CoA oxidase 1	Homo sapiens	46-49
29964470-4	2016	The optimal condition was determined as Fe2+:H2O2 ratio of 1:8, iron scraps reaction time of 4 h and Fenton reaction time of 60 min, under which 94.2% of AOX, 93.7% of chroma and 27.2% of TOC were removed.	Iron	64-68	acyl-CoA oxidase 1	Homo sapiens	154-157
29964470-5	2016	A comparison study revealed that the iron scraps-Fenton-coagulation combined process could achieve much better removal of AOX, chroma and TOC than any other single or combined processes of iron treatment, Fenton oxidation and coagulation.	Iron	37-41	acyl-CoA oxidase 1	Homo sapiens	122-125
27021659-9	2016	The Hb promotes HO-1 expression in KCs, thereby produces iron, bilirubin, and carbon monoxide (CO).	Iron	57-61	heme oxygenase 1	Rattus norvegicus	16-20
27343351-7	2016	Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA.	Iron	29-33	pyruvate dehydrogenase kinase 1	Homo sapiens	47-51
27273175-2	2016	This outcome is a logical consequence of the fact that the side-on peroxo ligand is bound to the syn face of the Fe(TMC) unit in the precursor.	Iron	113-115	synemin	Homo sapiens	97-100
27045926-10	2016	Whole-genome sequencing of CD-Nf and control-Nf showed genetic diversity of the iron acquisition systems and of some hemoglobin-related genes.	Iron	80-84	cerebral dopamine neurotrophic factor	Homo sapiens	27-32
26418842-0	2016	Further support for the association of GNPAT variant rs11558492 with severe iron overload in hemochromatosis.	Iron	76-80	glyceronephosphate O-acyltransferase	Homo sapiens	39-44
26845415-0	2016	GNPAT variant is associated with iron phenotype in healthy Taiwanese women: A population without the HFE C282Y mutation.	Iron	33-37	glyceronephosphate O-acyltransferase	Homo sapiens	0-5
27354540-6	2016	Hepatic iron concentration (HIC) was increased in Hfe(+/-) mice of both dietary groups.	Iron	8-12	homeostatic iron regulator	Mus musculus	50-53
27053376-1	2016	Coal is the main fuel for the direct reduced iron (DRI) plants of India, which are one of the major sources of fly ash generation.	Iron	45-49	cal	Drosophila melanogaster	0-4
27193999-4	2016	Through a forward genetic screening of Arabidopsis mutants showing DNA hypermethylation at the EPF2 promoter region, we identified the conserved iron-sulfur cluster assembly protein MET18.	Iron	145-149	Putative membrane lipoprotein	Arabidopsis thaliana	95-99
27152847-7	2016	Molecular docking showed that the hydroxyl group of 8:2 FTOH accesses the heme iron-oxo of CYP2C19 in an energetically favored orientation.	Iron	79-83	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	91-98
27152948-1	2016	OBJECTIVES: From previous data in animal models of cerebral ischemia, lipocalin-2 (LCN2), a protein related to neutrophil function and cellular iron homeostasis, is supposed to have a value as a biomarker in ischemic stroke patients.	Iron	144-148	lipocalin 2	Homo sapiens	70-81
27152948-1	2016	OBJECTIVES: From previous data in animal models of cerebral ischemia, lipocalin-2 (LCN2), a protein related to neutrophil function and cellular iron homeostasis, is supposed to have a value as a biomarker in ischemic stroke patients.	Iron	144-148	lipocalin 2	Homo sapiens	83-87
27152948-9	2016	CONCLUSIONS: LCN2 is expressed in the ischemic brain after temporary experimental ischemia and paralleled by the accumulation of cellular nonheme iron.	Iron	146-150	lipocalin 2	Homo sapiens	13-17
27203336-1	2016	We report a large enhancement of thermally injected spin current in normal metal (NM)/antiferromagnet (AF)/yttrium iron garnet (YIG), where a thin AF insulating layer of NiO or CoO can enhance the spin current from YIG to a NM by up to a factor of 10.	Iron	115-119	spindlin 1	Homo sapiens	52-56
26965530-2	2016	Low iron status increases FGF23 gene expression, and iron deficiency is common.	Iron	4-8	fibroblast growth factor 23	Homo sapiens	26-31
26965530-3	2016	We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associate with bone mineral density (BMD).	Iron	59-63	fibroblast growth factor 23	Homo sapiens	97-102
26965530-13	2016	C-terminal FGF23 correlated inversely with iron (white women r=-0.134, p&lt;0.0001; black women r=-0.188, p&lt;0.01), having a steeper slope at iron &lt;50mcg/dl than &gt;=50mcg/dl.	Iron	43-47	fibroblast growth factor 23	Homo sapiens	11-16
26965530-13	2016	C-terminal FGF23 correlated inversely with iron (white women r=-0.134, p&lt;0.0001; black women r=-0.188, p&lt;0.01), having a steeper slope at iron &lt;50mcg/dl than &gt;=50mcg/dl.	Iron	144-148	fibroblast growth factor 23	Homo sapiens	11-16
26965530-14	2016	Longitudinal changes in iron predicted changes in C-terminal FGF23.	Iron	24-28	fibroblast growth factor 23	Homo sapiens	61-66
26965530-18	2016	Serum iron did not relate to intact FGF23, but was inversely related to C-terminal FGF23.	Iron	6-10	fibroblast growth factor 23	Homo sapiens	83-88
26965530-21	2016	The influence of iron on FGF23 gene expression is not important in determining bone density in healthy premenopausal women.	Iron	17-21	fibroblast growth factor 23	Homo sapiens	25-30
26827808-0	2016	Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1.	Iron	0-4	DNA damage inducible transcript 4	Homo sapiens	97-102
26827808-8	2016	The increase in REDD1 abundance was rapidly reversed upon iron repletion of cells but was also attenuated by inhibitors of gene transcription, protein phosphatase 2A (PP2A) and by REDD1 siRNA--strategies that also antagonised the loss in mTORC1 signalling associated with iron depletion.	Iron	58-62	DNA damage inducible transcript 4	Homo sapiens	16-21
26827808-8	2016	The increase in REDD1 abundance was rapidly reversed upon iron repletion of cells but was also attenuated by inhibitors of gene transcription, protein phosphatase 2A (PP2A) and by REDD1 siRNA--strategies that also antagonised the loss in mTORC1 signalling associated with iron depletion.	Iron	272-276	DNA damage inducible transcript 4	Homo sapiens	16-21
26827808-9	2016	Our findings implicate REDD1 and PP2A as crucial regulators of mTORC1 activity in iron-depleted cells and indicate that their modulation may help mitigate atrophy of the intestinal mucosa that may occur in response to iron deficiency.	Iron	82-86	DNA damage inducible transcript 4	Homo sapiens	23-28
26827808-9	2016	Our findings implicate REDD1 and PP2A as crucial regulators of mTORC1 activity in iron-depleted cells and indicate that their modulation may help mitigate atrophy of the intestinal mucosa that may occur in response to iron deficiency.	Iron	218-222	DNA damage inducible transcript 4	Homo sapiens	23-28
26460054-0	2016	Dark Blood Magnetic Resonance Lymphangiography Using Dual-Agent Relaxivity Contrast (DARC-MRL): A Novel Method Combining Gadolinium and Iron Contrast Agents.	Iron	136-140	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	85-89
26779615-9	2016	Finally, increasing the serum levels of hepcidin or transferrin alleviates anemia and dyserythropoiesis by diminishing iron uptake by erythroblasts in mouse models.	Iron	119-123	transferrin	Mus musculus	52-63
27017620-4	2016	Here, using Caenorhabditis elegans, we show that iron overload induces the expression of sgk-1, encoding the serum and glucocorticoid-inducible kinase, to promote the level of ferritin and fat accumulation.	Iron	49-53	Serine/threonine-protein kinase sgk-1	Caenorhabditis elegans	89-94
27017620-6	2016	sgk-1 positively regulates the expression of acs-20 and vit-2, genes encoding homologs of the mammalian FATP1/4 fatty acid transport proteins and yolk lipoproteins, respectively, to facilitate lipid uptake and translocation for storage under iron overload.	Iron	242-246	serum/glucocorticoid regulated kinase 1	Homo sapiens	0-5
27017620-7	2016	This study reveals a completely novel pathway in which sgk-1 plays a central role to synergistically regulate iron and lipid homeostasis, offering not only experimental evidence supporting a previously unverified link between iron and obesity, but also novel insights into the pathogenesis of iron and obesity-related human metabolic diseases.	Iron	110-114	serum/glucocorticoid regulated kinase 1	Homo sapiens	55-60
27017620-7	2016	This study reveals a completely novel pathway in which sgk-1 plays a central role to synergistically regulate iron and lipid homeostasis, offering not only experimental evidence supporting a previously unverified link between iron and obesity, but also novel insights into the pathogenesis of iron and obesity-related human metabolic diseases.	Iron	226-230	serum/glucocorticoid regulated kinase 1	Homo sapiens	55-60
27017620-7	2016	This study reveals a completely novel pathway in which sgk-1 plays a central role to synergistically regulate iron and lipid homeostasis, offering not only experimental evidence supporting a previously unverified link between iron and obesity, but also novel insights into the pathogenesis of iron and obesity-related human metabolic diseases.	Iron	226-230	serum/glucocorticoid regulated kinase 1	Homo sapiens	55-60
27035325-0	2016	Icariin regulates systemic iron metabolism by increasing hepatic hepcidin expression through Stat3 and Smad1/5/8 signaling.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	65-73
27320606-13	2016	14-3-3zeta accelerates mitochondrial functions together with iron-dependent oxidative damage.	Iron	61-65	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	0-10
26991042-0	2016	Direct Observation of Ordered High-Spin-Low-Spin Intermediate States of an Iron(III) Three-Step Spin-Crossover Complex.	Iron	75-79	spindlin 1	Homo sapiens	35-39
26991042-0	2016	Direct Observation of Ordered High-Spin-Low-Spin Intermediate States of an Iron(III) Three-Step Spin-Crossover Complex.	Iron	75-79	spindlin 1	Homo sapiens	44-48
26991042-0	2016	Direct Observation of Ordered High-Spin-Low-Spin Intermediate States of an Iron(III) Three-Step Spin-Crossover Complex.	Iron	75-79	spindlin 1	Homo sapiens	44-48
26952981-3	2016	As previously described, we show that alpha-Spectrin and beta-Spectrin are essential to maintain a monolayered FE, but, contrary to previous work, spectrins are not required to control proliferation.	Iron	111-113	alpha Spectrin	Drosophila melanogaster	38-52
26952981-3	2016	As previously described, we show that alpha-Spectrin and beta-Spectrin are essential to maintain a monolayered FE, but, contrary to previous work, spectrins are not required to control proliferation.	Iron	111-113	beta Spectrin	Drosophila melanogaster	57-70
26952984-0	2016	Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.	Iron	155-159	zinc finger protein 36	Mus musculus	50-65
26952984-0	2016	Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.	Iron	155-159	zinc finger protein 36, C3H type-like 3	Mus musculus	80-87
27068103-1	2016	BACKGROUND: Hepcidin, a key regulator of iron metabolism, is produced mainly by interleukin-6 (IL-6) during inflammation.	Iron	41-45	hepcidin antimicrobial peptide	Mus musculus	12-20
27068103-14	2016	CONCLUSIONS: Our results suggest that overproduction of hepcidin by IL-6 signaling might be a major factor that leads to functionally iron-deficient cancer-related anemia in the LC-06-JCK model.	Iron	134-138	hepcidin antimicrobial peptide	Mus musculus	56-64
27048792-7	2016	However, when fed a low iron diet, female Ndfip2(-/-) mice showed a decrease in liver iron content, although they maintained normal serum iron levels and transferrin saturation, compared to wild type female mice that showed a reduction in serum iron and transferrin saturation.	Iron	24-28	Nedd4 family interacting protein 2	Mus musculus	42-48
27048792-7	2016	However, when fed a low iron diet, female Ndfip2(-/-) mice showed a decrease in liver iron content, although they maintained normal serum iron levels and transferrin saturation, compared to wild type female mice that showed a reduction in serum iron and transferrin saturation.	Iron	86-90	Nedd4 family interacting protein 2	Mus musculus	42-48
27048792-7	2016	However, when fed a low iron diet, female Ndfip2(-/-) mice showed a decrease in liver iron content, although they maintained normal serum iron levels and transferrin saturation, compared to wild type female mice that showed a reduction in serum iron and transferrin saturation.	Iron	86-90	Nedd4 family interacting protein 2	Mus musculus	42-48
27048792-7	2016	However, when fed a low iron diet, female Ndfip2(-/-) mice showed a decrease in liver iron content, although they maintained normal serum iron levels and transferrin saturation, compared to wild type female mice that showed a reduction in serum iron and transferrin saturation.	Iron	86-90	Nedd4 family interacting protein 2	Mus musculus	42-48
27048792-9	2016	We suggest that Ndfip2 controls DMT1 in the liver with female mice showing a greater response to altered dietary iron than the male mice.	Iron	113-117	Nedd4 family interacting protein 2	Mus musculus	16-22
27046124-3	2016	Hjv(-/-) mice accumulate excess iron in retina and exhibit aberrant vascularization and angiomas.	Iron	32-36	hemojuvelin BMP co-receptor	Mus musculus	0-3
27046124-14	2016	Exposure of RPE to excess iron and succinate as well as BMP6 and succinate increased VEGF expression.	Iron	26-30	vascular endothelial growth factor A	Mus musculus	85-89
26859104-4	2016	OBJECTIVE: To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates.	Iron	51-55	fibroblast growth factor 23	Homo sapiens	148-154
27012621-0	2016	The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	74-82
27012621-1	2016	Hepcidin, a master regulator of iron homeostasis, is a promising target in treatment of iron disorders such as hemochromatosis, anemia of inflammation and iron-deficiency anemia.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	0-8
26921633-6	2016	The levels of iron regulatory hormone hepcidin were markedly higher in HT mice even before iron loading while ferroportin levels did not alter.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	38-46
26921633-8	2016	SIGNIFICANCE: Thalassemic mice have different hepcidin/ferroportin and apoptotic protein expression as a defense mechanism to iron-overload compared with those in WT mice.	Iron	126-130	hepcidin antimicrobial peptide	Mus musculus	46-54
26797126-5	2016	Our findings suggest that IRP2 regulates the 24-h rhythm of transferrin receptor 1 (Tfr1) mRNA expression post-transcriptionally, by binding to RNA stem-loop structures known as iron-response elements.	Iron	178-182	iron responsive element binding protein 2	Mus musculus	26-30
26968518-6	2016	Eight soybean MATE transporters clustered together with the previously reported MATE proteins related to aluminum (Al) detoxification and iron translocation were further analyzed.	Iron	138-142	aluminum-activated citrate transporter	Glycine max	14-18
26968518-6	2016	Eight soybean MATE transporters clustered together with the previously reported MATE proteins related to aluminum (Al) detoxification and iron translocation were further analyzed.	Iron	138-142	aluminum-activated citrate transporter	Glycine max	80-84
26968518-10	2016	The cis-elements and expression patterns of eight soybean MATE genes related to Al detoxification/iron translocation were analyzed, and GmMATE75 was identified as a candidate gene for Al tolerance in soybean.	Iron	98-102	aluminum-activated citrate transporter	Glycine max	58-62
26919583-1	2016	The nonheme iron complex, [Fe(NO)(N3PyS)]BF4, is a rare example of an {FeNO}(7) species that exhibits spin-crossover behavior.	Iron	12-16	spindlin 1	Homo sapiens	102-106
26415695-0	2016	Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System.	Iron	12-14	pleiotropic drug resistance 9	Arabidopsis thaliana	75-81
26415695-0	2016	Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System.	Iron	12-14	pleiotropic drug resistance 9	Arabidopsis thaliana	82-86
26415695-0	2016	Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System.	Iron	12-14	iron-regulated transporter 1	Arabidopsis thaliana	112-116
26278055-6	2016	Iron transport and storage are also influenced by NGAL activity.	Iron	0-4	lipocalin 2	Homo sapiens	50-54
26852655-3	2016	Association was also detected between percent iron saturation (p=10(-8)) and variants in the chromosome 6 region containing both HFE and SLC17A2, which encodes a phosphate transport protein.	Iron	46-50	solute carrier family 17 member 2	Homo sapiens	137-144
26615413-10	2016	The data demonstrate transcriptional regulation of the components of cellular iron transporters during OC development and suggests that iron homeostasis may contribute to fine-tuning of the RANKL-induced OC development.	Iron	78-82	TNF superfamily member 11	Homo sapiens	190-195
26293821-6	2016	Infected Hepc-/- mice exhibited decreased iron accumulation in the renal medulla and significant attenuation of the renal inflammatory response.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	9-13
26403062-1	2016	OBJECTIVE: Hereditary hemochromatosis (HH) is a disease caused by mutations in the Hfe gene characterised by systemic iron overload and associated with an increased prevalence of osteoarthritis (OA) but the role of iron overload in the development of OA is still undefined.	Iron	118-122	homeostatic iron regulator	Mus musculus	83-86
26403062-5	2016	RESULTS: Hfe-KO mice showed a systemic iron overload and an increased iron accumulation in the knee synovial membrane following surgery.	Iron	39-43	homeostatic iron regulator	Mus musculus	9-12
26403062-5	2016	RESULTS: Hfe-KO mice showed a systemic iron overload and an increased iron accumulation in the knee synovial membrane following surgery.	Iron	70-74	homeostatic iron regulator	Mus musculus	9-12
26883939-3	2016	Here we report a non-invasive method to optically measure an established indicator of iron status, red blood cell zinc protoporphyrin, in the microcirculation of the lower lip.	Iron	86-90	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	172-175
27363157-0	2016	[Removal of AOX and Chroma in Biologically Treated Effluent of Chemical Dyestuff Wastewater with Nanoscale Ni/Fe].	Iron	110-112	acyl-CoA oxidase 1	Homo sapiens	12-15
27363157-3	2016	The results showed that the removal rates of AOX and chroma firstly increased and then decreased with the increase of the Ni loading, while continuously increased with the decrease of the initial wastewater pH and the increase of Ni/Fe dosage.	Iron	233-235	acyl-CoA oxidase 1	Homo sapiens	45-48
27363157-4	2016	The optimal condition was Ni loading of 1%, initial wastewater pH of 4.1 and Ni/Fe dosage of 3 g x L(-1), under which 29.2% of AOX and 79.6% of chroma were removed after 24 h reaction, and 50.6% of AOX and 80.7% of chroma were removed after 96 h reaction.	Iron	80-82	acyl-CoA oxidase 1	Homo sapiens	127-130
27363157-4	2016	The optimal condition was Ni loading of 1%, initial wastewater pH of 4.1 and Ni/Fe dosage of 3 g x L(-1), under which 29.2% of AOX and 79.6% of chroma were removed after 24 h reaction, and 50.6% of AOX and 80.7% of chroma were removed after 96 h reaction.	Iron	80-82	acyl-CoA oxidase 1	Homo sapiens	198-201
26845567-7	2016	Hemojuvelin was detected in the plasma membrane-enriched fractions of control animals as a full length protein of approximately 52 kDa; in iron deficient animals, the full length protein was partially cleaved at the N-terminus, resulting in an additional weak band of approximately 47 kDa.	Iron	139-143	hemojuvelin BMP co-receptor	Mus musculus	0-11
26608187-5	2016	Studies from our laboratory have shown that mice with a hepatocyte-specific deletion of Tfr2 recapitulate the hemochromatosis phenotype of the global Tfr2 knockout mice, suggesting that the hepatic expression of TFR2 is important in systemic iron homeostasis.	Iron	242-246	transferrin receptor 2	Mus musculus	88-92
26608187-5	2016	Studies from our laboratory have shown that mice with a hepatocyte-specific deletion of Tfr2 recapitulate the hemochromatosis phenotype of the global Tfr2 knockout mice, suggesting that the hepatic expression of TFR2 is important in systemic iron homeostasis.	Iron	242-246	transferrin receptor 2	Mus musculus	212-216
26608187-11	2016	These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin and thus macrophage iron homeostasis.	Iron	70-74	transferrin receptor 2	Mus musculus	44-48
26608187-11	2016	These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin and thus macrophage iron homeostasis.	Iron	149-153	transferrin receptor 2	Mus musculus	44-48
26491866-4	2016	Induction of iron restriction by means of transferrin infusions, minihepcidins or manipulation of the hepcidin pathway prevents iron overload, redistributes iron from parenchymal cells to macrophage stores and partially controls anaemia in beta-thalassaemic mice.	Iron	13-17	transferrin	Mus musculus	42-53
26491866-4	2016	Induction of iron restriction by means of transferrin infusions, minihepcidins or manipulation of the hepcidin pathway prevents iron overload, redistributes iron from parenchymal cells to macrophage stores and partially controls anaemia in beta-thalassaemic mice.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	69-77
26813504-5	2016	It was reported that FGF23 elevation in patients with CKD, who are often iron deficient.	Iron	73-77	fibroblast growth factor 23	Homo sapiens	21-26
26503005-4	2016	This strain could use BDE-209 as the sole carbon and energy source and degrade 65.1% of BDE-209 (initial concentration being 50 mg/L) within 144 h. To explore the BDE-209 degradation properties of this strain with the co-existed electronic donor, zerovalent iron/activated carbon (ZVI/AC) was introduced to build a microbial-chemical coupling system, which was found to promote the degradation of BDE-209 slightly (74.7% in 144 h).	Iron	258-262	homeobox D13	Homo sapiens	88-91
26503005-4	2016	This strain could use BDE-209 as the sole carbon and energy source and degrade 65.1% of BDE-209 (initial concentration being 50 mg/L) within 144 h. To explore the BDE-209 degradation properties of this strain with the co-existed electronic donor, zerovalent iron/activated carbon (ZVI/AC) was introduced to build a microbial-chemical coupling system, which was found to promote the degradation of BDE-209 slightly (74.7% in 144 h).	Iron	258-262	homeobox D13	Homo sapiens	88-91
26503005-4	2016	This strain could use BDE-209 as the sole carbon and energy source and degrade 65.1% of BDE-209 (initial concentration being 50 mg/L) within 144 h. To explore the BDE-209 degradation properties of this strain with the co-existed electronic donor, zerovalent iron/activated carbon (ZVI/AC) was introduced to build a microbial-chemical coupling system, which was found to promote the degradation of BDE-209 slightly (74.7% in 144 h).	Iron	258-262	homeobox D13	Homo sapiens	88-91
26503005-4	2016	This strain could use BDE-209 as the sole carbon and energy source and degrade 65.1% of BDE-209 (initial concentration being 50 mg/L) within 144 h. To explore the BDE-209 degradation properties of this strain with the co-existed electronic donor, zerovalent iron/activated carbon (ZVI/AC) was introduced to build a microbial-chemical coupling system, which was found to promote the degradation of BDE-209 slightly (74.7% in 144 h).	Iron	281-284	homeobox D13	Homo sapiens	88-91
26503005-4	2016	This strain could use BDE-209 as the sole carbon and energy source and degrade 65.1% of BDE-209 (initial concentration being 50 mg/L) within 144 h. To explore the BDE-209 degradation properties of this strain with the co-existed electronic donor, zerovalent iron/activated carbon (ZVI/AC) was introduced to build a microbial-chemical coupling system, which was found to promote the degradation of BDE-209 slightly (74.7% in 144 h).	Iron	281-284	homeobox D13	Homo sapiens	88-91
26503005-4	2016	This strain could use BDE-209 as the sole carbon and energy source and degrade 65.1% of BDE-209 (initial concentration being 50 mg/L) within 144 h. To explore the BDE-209 degradation properties of this strain with the co-existed electronic donor, zerovalent iron/activated carbon (ZVI/AC) was introduced to build a microbial-chemical coupling system, which was found to promote the degradation of BDE-209 slightly (74.7% in 144 h).	Iron	281-284	homeobox D13	Homo sapiens	88-91
26506980-0	2016	Mice with hepcidin-resistant ferroportin accumulate iron in the retina.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	10-18
26506980-9	2016	The results suggest that physiologic hepcidin levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.	Iron	160-164	hepcidin antimicrobial peptide	Mus musculus	37-45
26675814-8	2016	The conditions in the affected individuals of the family studied may define a novel form of neurodegeneration with brain iron accumulation, and GTPBP2 may be a novel neurodegeneration with brain iron accumulation gene.	Iron	195-199	GTP binding protein 2	Mus musculus	144-150
26560141-0	2016	NOD promoter-controlled AtIRT1 expression functions synergistically with NAS and FERRITIN genes to increase iron in rice grains.	Iron	108-112	iron-regulated transporter 1	Arabidopsis thaliana	24-30
26560141-6	2016	We expressed Arabidopsis IRT1 (AtIRT1) under control of the Medicago sativa EARLY NODULIN 12B promoter in our previously developed high-iron NFP rice lines expressing NICOTIANAMINE SYNTHASE (AtNAS1) and FERRITIN.	Iron	136-140	iron-regulated transporter 1	Arabidopsis thaliana	25-29
26560141-6	2016	We expressed Arabidopsis IRT1 (AtIRT1) under control of the Medicago sativa EARLY NODULIN 12B promoter in our previously developed high-iron NFP rice lines expressing NICOTIANAMINE SYNTHASE (AtNAS1) and FERRITIN.	Iron	136-140	iron-regulated transporter 1	Arabidopsis thaliana	31-37
26560141-7	2016	Transgenic rice lines expressing AtIRT1 alone had significant increases in iron and combined with NAS and FERRITIN increased iron to 9.6 microg/g DW in the polished grains that is 2.2-fold higher as compared to NFP lines.	Iron	75-79	iron-regulated transporter 1	Arabidopsis thaliana	33-39
26560141-7	2016	Transgenic rice lines expressing AtIRT1 alone had significant increases in iron and combined with NAS and FERRITIN increased iron to 9.6 microg/g DW in the polished grains that is 2.2-fold higher as compared to NFP lines.	Iron	125-129	iron-regulated transporter 1	Arabidopsis thaliana	33-39
26560141-9	2016	Our results demonstrate that the concerted expression of AtIRT1, AtNAS1 and PvFERRITIN synergistically increases iron in both polished and unpolished rice grains.	Iron	113-117	iron-regulated transporter 1	Arabidopsis thaliana	57-63
26560141-10	2016	AtIRT1 is therefore a valuable transporter for iron biofortification programs when used in combination with other genes encoding iron transporters and/or storage proteins.	Iron	47-51	iron-regulated transporter 1	Arabidopsis thaliana	0-6
26707217-5	2016	Active immunization of mice with recombinant antigens EcpA, EcpD, IutA, or IroN elicited high levels of total IgG antibody of IgG1/IgG2a isotypes, and were determined to be highly protective against E. coli infection in lethal and non-lethal sepsis challenges.	Iron	75-79	LOC105243590	Mus musculus	126-130
26806323-6	2016	Presumably, the g.9525_9526delCT mutation in CYP11B1 resulted in a truncated protein with a misfolded C-terminal domain that could not efficiently bind heme iron, substrate, and adrenodoxin and had lost its biochemical function.	Iron	157-161	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	45-52
26074023-5	2016	Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1.	Iron	102-106	glutathione peroxidase 1	Homo sapiens	181-185
26729415-5	2016	Therefore, we herein examined the roles of LCN2 in the regulation of intracellular iron concentrations, oxidative stress, DNA damage, and antioxidative functions using LCN2-overexpressing (ES2), and LCN2-silenced (RMG-1) CCC cell lines.	Iron	83-87	lipocalin 2	Homo sapiens	43-47
26729415-6	2016	The results of calcein staining indicated that the up-regulated expression of LCN2 correlated with increases in intracellular iron concentrations.	Iron	126-130	lipocalin 2	Homo sapiens	78-82
26729415-11	2016	Although LCN2 increased intracellular iron concentrations, LCN2-induced GSH may catalyze and override oxidative stress via CD44v and xCT, and subsequently enhance the survival of CCC cells in oxidative stress-rich endometriosis.	Iron	38-42	lipocalin 2	Homo sapiens	9-13
26406355-1	2016	UNLABELLED: Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes.	Iron	150-154	transferrin receptor 2	Mus musculus	216-238
26406355-2	2016	However, it is still not clear whether these molecules intersect in vivo with bone morphogenetic protein 6 (BMP6)/mothers against decapentaplegic (SMAD) homolog signaling, the main pathway up-regulating hepcidin expression in response to elevated hepatic iron.	Iron	255-259	hepcidin antimicrobial peptide	Mus musculus	203-211
26100117-5	2016	We observed that the K101Q mutation (due to c. 301 A&gt;C mutation) may prevent the binding of [Fe-S] to GLRX5 protein, while L148S (due to c. 443 T&gt;C mutation) may interfere with [Fe-S] transfer from GLRX5 to iron regulatory protein 1 (IRP1), mitochondrial aconitase (m-aconitase) and ferrochelatase.	Iron	96-100	ferrochelatase	Homo sapiens	272-303
27529627-8	2016	Inflammation and low serum iron level seems to diminish degradation capacity of FGF23 fragments.	Iron	27-31	fibroblast growth factor 23	Homo sapiens	80-85
26348414-2	2016	This study investigated three common heating methods (microwave (MW), hot-water (HW), hot-iron (HI)) for boar fat evaluation.	Iron	90-94	alcohol dehydrogenase iron containing 1	Homo sapiens	86-89
26348414-9	2016	Concluding from the present results, the hot-iron method appears to be advantageous for boar taint evaluation as compared to microwave and hot-water.	Iron	45-49	alcohol dehydrogenase iron containing 1	Homo sapiens	41-44
26384816-6	2016	In summary during iron supplementation the lower hepatic malaria numbers are regulated more by hepcidin than the absolute level of non-heme hepatic iron.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	95-103
26673059-4	2016	RESULTS: Quantification of SWCNTs by sensitively measuring iron content in sorted CSC populations using inductively coupled plasma-mass spectrometry confirmed the enhanced selective targeting of anti-CD44 SWCNT and immunohistochemistry analyses revealed enhanced colocalization with areas rich in CD44 receptors.	Iron	59-63	CD44 molecule (Indian blood group)	Homo sapiens	200-204
27073711-6	2016	We further demonstrate that PA and PI(3,5)P2 are also required for the ATP13A2-mediated protection against the toxic metals Mn(2+), Zn(2+), and Fe(3+), suggesting a general lipid-dependent activation mechanism of ATP13A2 in various PD-related stress conditions.	Iron	144-146	ATPase cation transporting 13A2	Homo sapiens	71-78
26662936-7	2016	We demonstrate the power of this promoter set for analysis of complex biological processes by investigating the contribution of root cell types in the IRT1-dependent root iron uptake.	Iron	171-175	iron-regulated transporter 1	Arabidopsis thaliana	151-155
26662936-8	2016	Our findings revealed the complex spatial expression pattern of IRT1 in both root epidermis and phloem companion cells and the requirement for IRT1 to be expressed in both cell types for proper iron homeostasis.	Iron	194-198	iron-regulated transporter 1	Arabidopsis thaliana	143-147
27295953-5	2016	One of the 14 peptides showed inhibitory activity at KDM4C demonstrating the need for an iron chelator in the pentapeptide series.	Iron	89-93	lysine demethylase 4C	Homo sapiens	53-58
26709821-5	2015	METHODS AND RESULTS: We assessed the impact of CFTR deficiency on systemic and tissue iron homeostasis as well as inflammation in wildtype and CFTR knockout (KO) mice.	Iron	86-90	cystic fibrosis transmembrane conductance regulator	Mus musculus	47-51
26527688-0	2015	Hepatocyte Nuclear Factor 4alpha Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver.	Iron	42-46	hepatic nuclear factor 4, alpha	Mus musculus	0-32
26527688-2	2015	Several iron-related genes are highly expressed in the liver, a tissue in which hepatocyte nuclear factor 4alpha (HNF4alpha) plays a critical role in controlling gene expression.	Iron	8-12	hepatic nuclear factor 4, alpha	Mus musculus	80-112
26527688-2	2015	Several iron-related genes are highly expressed in the liver, a tissue in which hepatocyte nuclear factor 4alpha (HNF4alpha) plays a critical role in controlling gene expression.	Iron	8-12	hepatic nuclear factor 4, alpha	Mus musculus	114-123
26527688-10	2015	These results suggest that Tfr2 is a novel target gene for HNF4alpha, and hepatic HNF4alpha plays a critical role in iron homeostasis.	Iron	117-121	transferrin receptor 2	Mus musculus	27-31
26527688-10	2015	These results suggest that Tfr2 is a novel target gene for HNF4alpha, and hepatic HNF4alpha plays a critical role in iron homeostasis.	Iron	117-121	hepatic nuclear factor 4, alpha	Mus musculus	82-91
26568372-6	2015	This difference in the yield of H2O2 formed between the systems along with the improvements observed in terms of the oxygen reduction onset and E1/2 in the case of Fe-Fe2O3/NGr reveals the activity modulation achieved for the latter is due to the coexistence of factors such as the presence of the mixed valancies of iron nanoparticles, small size and homogeneous distribution of Fe-Fe2O3 nanoparticles and the electronic modifications induced by the doped nitrogen in NGr.	Iron	164-166	reticulon 4 receptor	Homo sapiens	173-176
26568372-6	2015	This difference in the yield of H2O2 formed between the systems along with the improvements observed in terms of the oxygen reduction onset and E1/2 in the case of Fe-Fe2O3/NGr reveals the activity modulation achieved for the latter is due to the coexistence of factors such as the presence of the mixed valancies of iron nanoparticles, small size and homogeneous distribution of Fe-Fe2O3 nanoparticles and the electronic modifications induced by the doped nitrogen in NGr.	Iron	164-166	reticulon 4 receptor	Homo sapiens	469-472
26568372-6	2015	This difference in the yield of H2O2 formed between the systems along with the improvements observed in terms of the oxygen reduction onset and E1/2 in the case of Fe-Fe2O3/NGr reveals the activity modulation achieved for the latter is due to the coexistence of factors such as the presence of the mixed valancies of iron nanoparticles, small size and homogeneous distribution of Fe-Fe2O3 nanoparticles and the electronic modifications induced by the doped nitrogen in NGr.	Iron	317-321	reticulon 4 receptor	Homo sapiens	173-176
26568372-6	2015	This difference in the yield of H2O2 formed between the systems along with the improvements observed in terms of the oxygen reduction onset and E1/2 in the case of Fe-Fe2O3/NGr reveals the activity modulation achieved for the latter is due to the coexistence of factors such as the presence of the mixed valancies of iron nanoparticles, small size and homogeneous distribution of Fe-Fe2O3 nanoparticles and the electronic modifications induced by the doped nitrogen in NGr.	Iron	317-321	reticulon 4 receptor	Homo sapiens	469-472
26491070-2	2015	Here we demonstrate that mutations in HSPA9, a mitochondrial HSP70 homolog located in the chromosome 5q deletion syndrome 5q33 critical deletion interval and involved in mitochondrial Fe-S biogenesis, result in CSA inherited as an autosomal recessive trait.	Iron	184-188	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
26673824-8	2015	NGAL was more significantly associated with Al (r = 0.737, p &lt; 0.001), Cr (r = 0.705, p &lt; 0.001), Fe (r = 0.709, p &lt; 0.001), and Ni (r = 0.657, p &lt; 0.001) than was KIM-1, suggesting that NGAL may be a urinary biomarker for welding PM2.5 exposure.	Iron	104-106	lipocalin 2	Homo sapiens	0-4
26662398-2	2015	Hepcidin is an antimicrobial peptide and iron-regulatory molecule that primarily functions in the liver.	Iron	41-45	hepcidin	Larimichthys crocea	0-8
26122566-3	2015	Iron- and sulfate-reducing bacteria (FeRB and SRB), which have the potential to attenuate uranium and other metals by the enzymatic and/or abiotic reduction of metal ions, were found at all sites.	Iron	0-4	chaperonin containing TCP1 subunit 4	Homo sapiens	46-49
26423555-0	2015	Identification of CD4+ T-cell epitopes on iron-regulated surface determinant B of Staphylococcus aureus.	Iron	42-46	CD4 antigen	Mus musculus	18-21
26423555-1	2015	Iron-regulated surface determinant B (IsdB) of Staphylococcus aureus (S. aureus) is a highly conserved surface protein that can induce protective CD4(+) T-cell immune response.	Iron	0-4	CD4 antigen	Mus musculus	146-149
26606178-14	2015	Iron in asymptomatic plaque was present as hemosiderin/ferritin that stained positive with Prussian Blue, and was observed in association with CD68 positive macrophages.	Iron	0-4	CD68 molecule	Homo sapiens	143-147
25480729-6	2015	Given that FGF23 can be ectopically expressed in differentiated renal tubules and iron modulates FGF23 metabolism, an effect of iron on FGF23 expression in renal tubules is conceivable but remains to be confirmed.	Iron	82-86	fibroblast growth factor 23	Homo sapiens	97-102
25480729-6	2015	Given that FGF23 can be ectopically expressed in differentiated renal tubules and iron modulates FGF23 metabolism, an effect of iron on FGF23 expression in renal tubules is conceivable but remains to be confirmed.	Iron	82-86	fibroblast growth factor 23	Homo sapiens	97-102
26333047-9	2015	The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1.	Iron	26-28	iron-regulated transporter 1	Arabidopsis thaliana	47-51
26333047-9	2015	The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1.	Iron	203-205	iron-regulated transporter 1	Arabidopsis thaliana	47-51
26422458-2	2015	Here, we describe an iron-sulfur cluster in Asp1, a dual-function kinase/phosphatase that regulates cell morphogenesis in Schizosaccharomyces pombe.	Iron	21-25	beta-secretase 2	Homo sapiens	44-48
26422458-7	2015	Purified, recombinant Asp1(371-920) contained iron and acid-labile sulfide, but the stoichiometry (0.8 atoms of each per protein molecule) indicates incomplete iron-sulfur cluster assembly.	Iron	46-50	beta-secretase 2	Homo sapiens	22-26
26422458-8	2015	We reconstituted the Fe-S cluster in vitro under anaerobic conditions, which increased the stoichiometry to approximately 2 atoms of iron and acid-labile sulfide per Asp1 molecule.	Iron	21-25	beta-secretase 2	Homo sapiens	166-170
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	201-209
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	211-216
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	358-366
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	201-209
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	201-209
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	201-209
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	201-209
26294671-4	2015	That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	201-209
26500891-0	2015	Decreased RXRalpha is Associated with Increased beta-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors.	Iron	73-75	catenin (cadherin associated protein), beta 1	Mus musculus	48-60
26500891-6	2015	We observed increased accumulation of the transcription factor TCF4 and its co-activator beta-catenin as well as their downstream oncogenic target protein cyclin-D1 in (56)Fe ion-induced intestinal tumors.	Iron	172-174	catenin (cadherin associated protein), beta 1	Mus musculus	89-101
26500891-6	2015	We observed increased accumulation of the transcription factor TCF4 and its co-activator beta-catenin as well as their downstream oncogenic target protein cyclin-D1 in (56)Fe ion-induced intestinal tumors.	Iron	172-174	cyclin D1	Mus musculus	155-164
26500891-8	2015	This indicates that decreased UPP targeting of beta-catenin due to downregulation of RXRalpha can contribute to further accumulation of beta-catenin and to (56)Fe-induced tumorigenesis.	Iron	160-162	catenin (cadherin associated protein), beta 1	Mus musculus	47-59
26870796-6	2015	Surprisingly, the liver was also iron deficient, and production of the iron regulatory hormone hepcidin was depressed.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	95-103
26047483-20	2015	We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin.	Iron	75-79	homeostatic iron regulator	Mus musculus	176-179
26360295-1	2015	Previous studies by our group demonstrated the key role of iron in Schwann cell maturation through an increase in cAMP, PKA activation and CREB phosphorylation.	Iron	59-63	cAMP responsive element binding protein 1	Homo sapiens	139-143
26390966-3	2015	Siderocalin (LCN2) is a key antibacterial component of the innate immune system and sequesters bacterial siderophores to prevent acquisition of iron.	Iron	144-148	lipocalin 2	Homo sapiens	13-17
26324903-1	2015	Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin.	Iron	51-55	transferrin	Mus musculus	116-127
26324903-1	2015	Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin.	Iron	104-108	transferrin	Mus musculus	116-127
26374030-0	2015	The spin and orbital contributions to the total magnetic moments of free Fe, Co, and Ni clusters.	Iron	73-75	spindlin 1	Homo sapiens	4-8
26392811-3	2015	Heme oxygenase-1 (HO-1)-a stress-responsive enzyme that catabolizes heme into iron, carbon monoxide, and biliverdin-has an important role in the neuroprotective mechanism against ischemic stroke.	Iron	78-82	heme oxygenase 1	Rattus norvegicus	0-16
26392811-3	2015	Heme oxygenase-1 (HO-1)-a stress-responsive enzyme that catabolizes heme into iron, carbon monoxide, and biliverdin-has an important role in the neuroprotective mechanism against ischemic stroke.	Iron	78-82	heme oxygenase 1	Rattus norvegicus	18-22
26327381-1	2015	Maxi-ferritins are ubiquitous iron-storage proteins with a common cage architecture made up of 24 identical subunits of five alpha-helices that drive iron biomineralization through catalytic iron(II) oxidation occurring at oxidoreductase sites (OS).	Iron	150-154	thioredoxin reductase 1	Homo sapiens	223-237
26327381-1	2015	Maxi-ferritins are ubiquitous iron-storage proteins with a common cage architecture made up of 24 identical subunits of five alpha-helices that drive iron biomineralization through catalytic iron(II) oxidation occurring at oxidoreductase sites (OS).	Iron	150-154	thioredoxin reductase 1	Homo sapiens	223-237
26327381-3	2015	Multiple binding sites were identified that define the iron path from the entry ion channels to the oxidoreductase sites.	Iron	55-59	thioredoxin reductase 1	Homo sapiens	100-114
26327381-5	2015	A comparative analysis of the iron sites in the two proteins identifies new reaction intermediates and underlines clear differences in the pattern of ligands that define the additional iron sites that precede the oxidoreductase binding sites along this path.	Iron	30-34	thioredoxin reductase 1	Homo sapiens	213-227
26071548-3	2015	Disruption of frataxin has been found to induce mitochondrial iron overload and subsequent ROS production.	Iron	62-66	frataxin	Mus musculus	14-22
26071548-9	2015	Our data also suggest that increased frataxin mitigated mitochondrial iron overload and subsequent ROS production, thus preserving mitochondrial membrane integrity and viability of cardiomyocytes.	Iron	70-74	frataxin	Mus musculus	37-45
25688831-0	2015	Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron-sulfur cluster assembly.	Iron	125-129	2,4-dienoyl-CoA reductase 1	Homo sapiens	32-37
25781546-1	2015	BACKGROUND: The peptide hepcidin plays a central role in regulating dietary iron absorption and body iron distribution.	Iron	76-80	hepcidin antimicrobial peptide	Mus musculus	24-32
25781546-1	2015	BACKGROUND: The peptide hepcidin plays a central role in regulating dietary iron absorption and body iron distribution.	Iron	101-105	hepcidin antimicrobial peptide	Mus musculus	24-32
25781546-3	2015	Hepcidin has been suggested as a promising diagnostic marker for iron-related disorders.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	0-8
25781546-10	2015	RESULTS: We show that the LC-MS/MS is suitable for accurate determination of hepcidin-25 in clinical samples, thereby representing a useful tool for the clinical diagnosis and follow-up of iron-related diseases.	Iron	189-193	hepcidin antimicrobial peptide	Mus musculus	77-85
25781546-12	2015	CONCLUSIONS: Therefore, we propose this adaptive LC-MS/MS method as a suitable method for accurate determination of hepcidin-25 in clinical samples and as a major tool contributing to the clinical diagnosis, follow-up and management of iron-related disorders.	Iron	236-240	hepcidin antimicrobial peptide	Mus musculus	116-124
26323096-0	2015	Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status.	Iron	27-31	hepcidin antimicrobial peptide	Sus scrofa	8-16
26323096-0	2015	Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status.	Iron	27-31	hepcidin antimicrobial peptide	Sus scrofa	87-95
26323096-0	2015	Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status.	Iron	46-50	hepcidin antimicrobial peptide	Sus scrofa	8-16
26323096-0	2015	Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status.	Iron	46-50	hepcidin antimicrobial peptide	Sus scrofa	87-95
26323096-0	2015	Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status.	Iron	46-50	hepcidin antimicrobial peptide	Sus scrofa	8-16
26323096-0	2015	Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status.	Iron	46-50	hepcidin antimicrobial peptide	Sus scrofa	87-95
26323096-4	2015	Since the discovery of hepcidin many studies confirmed its role as key regulator of iron metabolism and pointed out the assessment of its concentrations in biological fluids as diagnostic tool for iron-related disorder.	Iron	84-88	hepcidin antimicrobial peptide	Sus scrofa	23-31
26323096-4	2015	Since the discovery of hepcidin many studies confirmed its role as key regulator of iron metabolism and pointed out the assessment of its concentrations in biological fluids as diagnostic tool for iron-related disorder.	Iron	197-201	hepcidin antimicrobial peptide	Sus scrofa	23-31
26323096-5	2015	Here we demonstrate that urine hepcidin-25 levels measured by a combination of weak cation exchange chromatography and time-of-flight mass spectrometry (WCX-TOF MS) are highly correlated with mRNA hepcidin expression in the liver and plasma hepcidin-25 concentrations in anemic and iron-supplemented 28-day old piglets.	Iron	282-286	hepcidin antimicrobial peptide	Sus scrofa	31-39
26323096-6	2015	We also found a high correlation between urine hepcidin level and hepatic non-heme iron content.	Iron	83-87	hepcidin antimicrobial peptide	Sus scrofa	47-55
26154705-0	2015	Effect of Caseinophosphopeptides from alphas- and beta-Casein on Iron Bioavailability in HuH7 Cells.	Iron	65-69	MIR7-3 host gene	Homo sapiens	89-93
26154705-7	2015	HuH7 human hepatoma cells show many differentiated functions of liver cells in vivo and can be used to evaluate iron bioavailability (ferritin content and soluble transferrin receptor) from Fe-alpha-CPPs and Fe-beta-CPPs complexes.	Iron	112-116	MIR7-3 host gene	Homo sapiens	0-4
26142330-3	2015	AIM: To determine GDF-15 levels in children and adolescents with TI and the relation to hemolysis, iron overload and cardiovascular complications.	Iron	99-103	growth differentiation factor 15	Homo sapiens	18-24
25605615-0	2015	Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.	Iron	119-123	glyceronephosphate O-acyltransferase	Homo sapiens	82-87
25605615-4	2015	A variant in the GNPAT gene showed the most significant association with severe iron overload (P = 3 x 10(-6) ; P = 0.033 by the likelihood ratio test after correction for multiple comparisons).	Iron	80-84	glyceronephosphate O-acyltransferase	Homo sapiens	17-22
25605615-5	2015	Sixteen of twenty-two participants with severe iron overload had glyceronephosphate O-acyltransferase (GNPAT) polymorphism p.D519G (rs11558492; 15 heterozygotes, one homozygote).	Iron	47-51	glyceronephosphate O-acyltransferase	Homo sapiens	103-108
25605615-9	2015	CONCLUSION: GNPAT p.D519G is associated with a high-iron phenotype in HFE C282Y homozygotes and may participate in hepcidin regulation.	Iron	52-56	glyceronephosphate O-acyltransferase	Homo sapiens	12-17
25820544-0	2015	Glyceronephosphate O-acyltransferase as a hemochromatosis modifier gene: Another iron in the fire?	Iron	81-85	glyceronephosphate O-acyltransferase	Homo sapiens	0-36
26275132-1	2015	PURPOSE: High RPE iron levels have been associated with age-related macular degeneration.	Iron	18-22	ribulose-5-phosphate-3-epimerase	Mus musculus	14-17
26275132-2	2015	Mutation of the ferroxidase ceruloplasmin leads to RPE iron accumulation and degeneration in patients with aceruloplasminemia; mice lacking ceruloplasmin and its homolog hephaestin have a similar RPE degeneration.	Iron	55-59	ribulose-5-phosphate-3-epimerase	Homo sapiens	51-54
26275132-3	2015	To determine whether a high iron diet (HID) could cause RPE iron accumulation, possibly contributing to RPE oxidative stress in AMD, we tested the effect of dietary iron on mouse RPE iron.	Iron	28-32	ribulose-5-phosphate-3-epimerase	Mus musculus	56-59
26275132-3	2015	To determine whether a high iron diet (HID) could cause RPE iron accumulation, possibly contributing to RPE oxidative stress in AMD, we tested the effect of dietary iron on mouse RPE iron.	Iron	28-32	ribulose-5-phosphate-3-epimerase	Mus musculus	104-107
26275132-3	2015	To determine whether a high iron diet (HID) could cause RPE iron accumulation, possibly contributing to RPE oxidative stress in AMD, we tested the effect of dietary iron on mouse RPE iron.	Iron	28-32	ribulose-5-phosphate-3-epimerase	Mus musculus	104-107
26275132-3	2015	To determine whether a high iron diet (HID) could cause RPE iron accumulation, possibly contributing to RPE oxidative stress in AMD, we tested the effect of dietary iron on mouse RPE iron.	Iron	60-64	ribulose-5-phosphate-3-epimerase	Mus musculus	56-59
26275132-3	2015	To determine whether a high iron diet (HID) could cause RPE iron accumulation, possibly contributing to RPE oxidative stress in AMD, we tested the effect of dietary iron on mouse RPE iron.	Iron	60-64	ribulose-5-phosphate-3-epimerase	Mus musculus	56-59
26275132-3	2015	To determine whether a high iron diet (HID) could cause RPE iron accumulation, possibly contributing to RPE oxidative stress in AMD, we tested the effect of dietary iron on mouse RPE iron.	Iron	60-64	ribulose-5-phosphate-3-epimerase	Mus musculus	56-59
26275132-9	2015	Analysis by qPCR showed changes in mRNA levels of iron-responsive genes, indicating moderately increased iron in the RPE of 10-month HID mice.	Iron	50-54	ribulose-5-phosphate-3-epimerase	Mus musculus	117-120
26275132-9	2015	Analysis by qPCR showed changes in mRNA levels of iron-responsive genes, indicating moderately increased iron in the RPE of 10-month HID mice.	Iron	105-109	ribulose-5-phosphate-3-epimerase	Mus musculus	117-120
26275132-11	2015	CONCLUSIONS: These findings indicate that iron absorbed from the diet can modestly increase the level of iron deposition in the wild-type mouse RPE without causing RPE or retinal degeneration.	Iron	42-46	ribulose-5-phosphate-3-epimerase	Mus musculus	144-147
26275132-11	2015	CONCLUSIONS: These findings indicate that iron absorbed from the diet can modestly increase the level of iron deposition in the wild-type mouse RPE without causing RPE or retinal degeneration.	Iron	105-109	ribulose-5-phosphate-3-epimerase	Mus musculus	144-147
25716557-7	2015	Some bacteria have developed resistance to NGAL-mediated iron sequestration by production of modified siderophores that are not recognized by NGAL.	Iron	57-61	lipocalin 2	Homo sapiens	43-47
26002909-0	2015	GENERAL CONTROL NONREPRESSED PROTEIN5-Mediated Histone Acetylation of FERRIC REDUCTASE DEFECTIVE3 Contributes to Iron Homeostasis in Arabidopsis.	Iron	113-117	general control non-repressible 5	Arabidopsis thaliana	0-37
26002909-2	2015	Here, we report that a mutation in GENERAL CONTROL NONREPRESSED PROTEIN5 (GCN5) impaired iron translocation from the root to the shoot in Arabidopsis (Arabidopsis thaliana).	Iron	89-93	general control non-repressible 5	Arabidopsis thaliana	35-72
26002909-2	2015	Here, we report that a mutation in GENERAL CONTROL NONREPRESSED PROTEIN5 (GCN5) impaired iron translocation from the root to the shoot in Arabidopsis (Arabidopsis thaliana).	Iron	89-93	general control non-repressible 5	Arabidopsis thaliana	74-78
26002909-3	2015	Illumina high-throughput sequencing revealed 879 GCN5-regulated candidate genes potentially involved in iron homeostasis.	Iron	104-108	general control non-repressible 5	Arabidopsis thaliana	49-53
26002909-4	2015	Chromatin immunoprecipitation assays indicated that five genes (At3G08040, At2G01530, At2G39380, At2G47160, and At4G05200) are direct targets of GCN5 in iron homeostasis regulation.	Iron	153-157	general control non-repressible 5	Arabidopsis thaliana	145-149
26002909-8	2015	Collectively, these data suggest that GCN5 plays a critical role in FRD3-mediated iron homeostasis.	Iron	82-86	general control non-repressible 5	Arabidopsis thaliana	38-42
25670719-1	2015	OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) is a component of innate immunity that prevents iron uptake by microorganisms.	Iron	109-113	lipocalin 2	Homo sapiens	11-53
25670719-1	2015	OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) is a component of innate immunity that prevents iron uptake by microorganisms.	Iron	109-113	lipocalin 2	Homo sapiens	55-59
26102537-0	2015	Finite temperature orbital and spin magnetism of small Fe linear chains.	Iron	55-57	spindlin 1	Homo sapiens	31-35
25917001-7	2015	Two possible explanations of this finding are the presence of the host-guest C42 H67 O35 Na-Fe complex, in which Fe is in the cavity, or the presence of the adduct C42 H67 O34 Na-FeO with FeO on the outer surface; the formation of these complexes are supported by the hydrophobicity of Fe and hydrophilicity of FeO, respectively.	Iron	92-94	CDK5 regulatory subunit associated protein 1	Homo sapiens	77-80
25917001-7	2015	Two possible explanations of this finding are the presence of the host-guest C42 H67 O35 Na-Fe complex, in which Fe is in the cavity, or the presence of the adduct C42 H67 O34 Na-FeO with FeO on the outer surface; the formation of these complexes are supported by the hydrophobicity of Fe and hydrophilicity of FeO, respectively.	Iron	113-115	CDK5 regulatory subunit associated protein 1	Homo sapiens	77-80
25917001-7	2015	Two possible explanations of this finding are the presence of the host-guest C42 H67 O35 Na-Fe complex, in which Fe is in the cavity, or the presence of the adduct C42 H67 O34 Na-FeO with FeO on the outer surface; the formation of these complexes are supported by the hydrophobicity of Fe and hydrophilicity of FeO, respectively.	Iron	113-115	CDK5 regulatory subunit associated protein 1	Homo sapiens	77-80
25917001-8	2015	Due to the presence of 12 % of intact C42 H70 O35 Na-Fe complex and an estimated Fe/FeO ratio of approximately 10(2) , host-guest formation is assumed to be more significant.	Iron	53-55	CDK5 regulatory subunit associated protein 1	Homo sapiens	38-41
26073059-3	2015	For this iron-oxo core, the magnetic susceptibility analysis proposed a Heisenberg-Dirac-van Vleck (HDvV) mechanism that leads to an intermediate spin ground state of S=7/2 or 9/2.	Iron	9-13	spindlin 1	Homo sapiens	146-150
26193703-11	2015	Finally, each doubling in the intake of iron was related to an 82% lower probability of having higher FGF23 levels.	Iron	40-44	fibroblast growth factor 23	Homo sapiens	102-107
26173596-9	2015	Associations between Cd and PEG3 and PLAGL1 DNA methylation were stronger in infants born to women with low concentrations of Fe (p &lt; 0.05).	Iron	126-128	PLAG1 like zinc finger 1	Homo sapiens	37-43
26028554-2	2015	These tissues preferentially load iron because they take up non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload.	Iron	34-38	transferrin	Mus musculus	64-75
26028554-2	2015	These tissues preferentially load iron because they take up non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload.	Iron	82-86	transferrin	Mus musculus	64-75
26028554-2	2015	These tissues preferentially load iron because they take up non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload.	Iron	82-86	transferrin	Mus musculus	64-75
25862412-1	2015	Excess circulating iron is stored in the liver, and requires reduction of non-Tf-bound iron (NTBI) and transferrin (Tf) iron at the plasma membrane and endosomes, respectively, by ferrireductase (FR) proteins for transport across biological membranes through divalent metal transporters.	Iron	19-23	transferrin	Mus musculus	78-80
25862412-1	2015	Excess circulating iron is stored in the liver, and requires reduction of non-Tf-bound iron (NTBI) and transferrin (Tf) iron at the plasma membrane and endosomes, respectively, by ferrireductase (FR) proteins for transport across biological membranes through divalent metal transporters.	Iron	19-23	transferrin	Mus musculus	103-114
25862412-1	2015	Excess circulating iron is stored in the liver, and requires reduction of non-Tf-bound iron (NTBI) and transferrin (Tf) iron at the plasma membrane and endosomes, respectively, by ferrireductase (FR) proteins for transport across biological membranes through divalent metal transporters.	Iron	19-23	transferrin	Mus musculus	116-118
25862412-1	2015	Excess circulating iron is stored in the liver, and requires reduction of non-Tf-bound iron (NTBI) and transferrin (Tf) iron at the plasma membrane and endosomes, respectively, by ferrireductase (FR) proteins for transport across biological membranes through divalent metal transporters.	Iron	87-91	transferrin	Mus musculus	78-80
25862412-1	2015	Excess circulating iron is stored in the liver, and requires reduction of non-Tf-bound iron (NTBI) and transferrin (Tf) iron at the plasma membrane and endosomes, respectively, by ferrireductase (FR) proteins for transport across biological membranes through divalent metal transporters.	Iron	87-91	transferrin	Mus musculus	78-80
26044037-5	2015	Extracts from black bean seed coats strongly inhibited iron uptake.	Iron	55-59	brain expressed associated with NEDD4 1	Homo sapiens	20-24
26044037-8	2015	The ability of some polyphenols to promote iron uptake and the identification of specific polyphenols that inhibit Fe uptake suggest a potential for breeding bean lines with improved iron nutritional qualities.	Iron	115-117	brain expressed associated with NEDD4 1	Homo sapiens	158-162
26044037-8	2015	The ability of some polyphenols to promote iron uptake and the identification of specific polyphenols that inhibit Fe uptake suggest a potential for breeding bean lines with improved iron nutritional qualities.	Iron	183-187	brain expressed associated with NEDD4 1	Homo sapiens	158-162
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	6-8	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	72-76
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	6-8	ferroxidase	Saccharomyces cerevisiae S288C	266-270
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	6-8	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	317-321
25782577-5	2015	Yeast Fe-S cluster assembly is accomplished using the scaffold protein (Isu1) as the molecular foundation, with assistance from the cysteine desulfurase (Nfs1) to provide sulfur, the accessory protein (Isd11) to regulate Nfs1 activity, the yeast frataxin homologue (Yfh1) to regulate Nfs1 activity and participate in Isu1 Fe loading possibly as a chaperone, and the ferredoxin (Yah1) to provide reducing equivalents for assembly.	Iron	322-324	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	72-76
25782577-6	2015	In this report, we utilize calorimetric and spectroscopic methods to provide molecular insight into how wt-Isu1 from S. cerevisiae becomes loaded with iron.	Iron	151-155	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	107-111
25649872-4	2015	Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation.	Iron	163-167	RoBo-1	Rattus norvegicus	6-10
25715026-7	2015	Hypoxia-inducible factor 1, alpha subunit (HIF2alpha) protein expression was assessed in bone marrow sections from iron-deficient rats and vascular endothelial growth factor (VEGF)-A in culture supernatants.	Iron	115-119	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-41
25715026-7	2015	Hypoxia-inducible factor 1, alpha subunit (HIF2alpha) protein expression was assessed in bone marrow sections from iron-deficient rats and vascular endothelial growth factor (VEGF)-A in culture supernatants.	Iron	115-119	endothelial PAS domain protein 1	Rattus norvegicus	43-52
25715026-11	2015	HIF2alpha protein expression was increased in megakaryocytes from iron-deficient rats, and VEGF-A concentration was higher in iron-deficient culture supernatants.	Iron	66-70	endothelial PAS domain protein 1	Rattus norvegicus	0-9
26078704-9	2015	The loss of DMT1 can reduce the content of iron in bone.	Iron	43-47	RoBo-1	Rattus norvegicus	12-16
25608116-1	2015	AIMS: Hereditary hemochromatosis (HH) is an iron overload disease that is caused by mutations in HFE, HJV, and several other genes.	Iron	44-48	homeostatic iron regulator	Mus musculus	97-100
25608116-1	2015	AIMS: Hereditary hemochromatosis (HH) is an iron overload disease that is caused by mutations in HFE, HJV, and several other genes.	Iron	44-48	hemojuvelin BMP co-receptor	Mus musculus	102-105
25918944-1	2015	Electronic Structure and Metal Oxidation States in Iron-PNN Complexes as a Representative Case Study.	Iron	51-55	pinin, desmosome associated protein	Homo sapiens	56-59
25802332-0	2015	Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium.	Iron	0-4	complement C3	Homo sapiens	43-45
25802332-3	2015	In this study, we investigated the molecular mechanisms by which complement component 3 (C3), a central protein in the complement cascade, is up-regulated by iron in RPE cells.	Iron	158-162	complement C3	Homo sapiens	65-87
25802332-3	2015	In this study, we investigated the molecular mechanisms by which complement component 3 (C3), a central protein in the complement cascade, is up-regulated by iron in RPE cells.	Iron	158-162	complement C3	Homo sapiens	89-91
25802332-4	2015	Modulation of TGF-beta signaling, involving ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-delta, is responsible for iron-induced C3 expression.	Iron	120-124	CCAAT enhancer binding protein delta	Homo sapiens	63-99
25802332-4	2015	Modulation of TGF-beta signaling, involving ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-delta, is responsible for iron-induced C3 expression.	Iron	120-124	complement C3	Homo sapiens	133-135
25802332-6	2015	Pharmacologic inhibition of either ERK1/2 or SMAD3 phosphorylation decreased iron-induced C3 expression levels.	Iron	77-81	complement C3	Homo sapiens	90-92
25802332-7	2015	Knockdown of SMAD3 blocked the iron-induced up-regulation and nuclear accumulation of CCAAT/enhancer-binding protein-delta, a transcription factor that has been shown previously to bind the basic leucine zipper 1 domain in the C3 promoter.	Iron	31-35	CCAAT enhancer binding protein delta	Homo sapiens	86-122
25802332-7	2015	Knockdown of SMAD3 blocked the iron-induced up-regulation and nuclear accumulation of CCAAT/enhancer-binding protein-delta, a transcription factor that has been shown previously to bind the basic leucine zipper 1 domain in the C3 promoter.	Iron	31-35	complement C3	Homo sapiens	227-229
25802332-8	2015	We show herein that mutation of this domain reduced iron-induced C3 promoter activity.	Iron	52-56	complement C3	Homo sapiens	65-67
25802332-9	2015	In vivo studies support our in vitro finding of iron-induced C3 up-regulation.	Iron	48-52	complement C3	Homo sapiens	61-63
25802332-12	2015	The molecular events in the iron-C3 pathway represent therapeutic targets for AMD or other diseases exacerbated by iron-induced local complement dysregulation.	Iron	28-32	complement C3	Homo sapiens	33-35
25955433-1	2015	This study investigates the regulation of hepcidin, the key iron-regulatory molecule, by alcohol and hydrogen peroxide (H2O2) in glutathione peroxidase-1 (gpx-1(-/-)) and catalase (catalase(-/-)) knockout mice.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	42-50
25616571-3	2015	Pathological iron accumulation in parenchyma is caused by chronic exposure to non-transferrin bound iron in plasma.	Iron	13-17	transferrin	Mus musculus	82-93
25616571-4	2015	The iron scavenger and transport protein transferrin is a potential treatment being studied for correction of anemia.	Iron	4-8	transferrin	Mus musculus	41-52
25616571-5	2015	However, transferrin may also function to prevent or reduce iron loading of tissues when exposure to non-transferrin bound iron increases.	Iron	60-64	transferrin	Mus musculus	9-20
25616571-5	2015	However, transferrin may also function to prevent or reduce iron loading of tissues when exposure to non-transferrin bound iron increases.	Iron	123-127	transferrin	Mus musculus	9-20
25616571-7	2015	Mice with the Hbb(th3/+) phenotype have mild to moderate anemia and consistent tissue iron accumulation in the spleen, liver, kidneys and myocardium.	Iron	86-90	hemoglobin beta chain complex	Mus musculus	14-17
25616571-10	2015	Apotransferrin treatment was also found to attenuate transfusion-mediated increases in plasma non-transferrin bound iron and associated excess tissue iron loading.	Iron	116-120	transferrin	Mus musculus	3-14
25616571-10	2015	Apotransferrin treatment was also found to attenuate transfusion-mediated increases in plasma non-transferrin bound iron and associated excess tissue iron loading.	Iron	150-154	transferrin	Mus musculus	3-14
25616571-11	2015	These therapeutic effects were associated with normalization of transferrin saturation and suppressed plasma non-transferrin bound iron.	Iron	131-135	transferrin	Mus musculus	113-124
25609138-12	2015	Single Hjv(-)/(-) and double Hfe(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload.	Iron	74-78	homeostatic iron regulator	Mus musculus	29-32
25609138-12	2015	Single Hjv(-)/(-) and double Hfe(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload.	Iron	74-78	hemojuvelin BMP co-receptor	Mus musculus	39-42
25591911-8	2015	These results suggest that iron may positively regulate STAT1 phosphorylation and following signaling to express ISG56, RIG-I and CXCL10 in U373MG cells treated with poly IC.	Iron	27-31	signal transducer and activator of transcription 1	Homo sapiens	56-61
25591911-8	2015	These results suggest that iron may positively regulate STAT1 phosphorylation and following signaling to express ISG56, RIG-I and CXCL10 in U373MG cells treated with poly IC.	Iron	27-31	DExD/H-box helicase 58	Homo sapiens	120-125
25591911-8	2015	These results suggest that iron may positively regulate STAT1 phosphorylation and following signaling to express ISG56, RIG-I and CXCL10 in U373MG cells treated with poly IC.	Iron	27-31	C-X-C motif chemokine ligand 10	Homo sapiens	130-136
25860887-10	2015	We propose that NPCs, sensing the iron flux, not only increase hepcidin through Bmp6 with a paracrine mechanism to control systemic iron homeostasis but, controlling hepcidin, they regulate their own ferroportin, inducing iron retention or release and further modulating Bmp6 production in an autocrine manner.	Iron	34-38	hepcidin antimicrobial peptide	Mus musculus	63-71
25860887-10	2015	We propose that NPCs, sensing the iron flux, not only increase hepcidin through Bmp6 with a paracrine mechanism to control systemic iron homeostasis but, controlling hepcidin, they regulate their own ferroportin, inducing iron retention or release and further modulating Bmp6 production in an autocrine manner.	Iron	34-38	hepcidin antimicrobial peptide	Mus musculus	166-174
25860887-11	2015	This mechanism, that contributes to protect HC from iron loading or deficiency, is lost in disease models of hepcidin production.	Iron	52-56	hepcidin antimicrobial peptide	Mus musculus	109-117
25662334-3	2015	The iron hormone hepcidin is activated by such stimuli causing degradation of the iron exporter ferroportin and reduced iron release from macrophages, suggesting that hepcidin is the crucial effector of inflammatory hypoferremia.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	17-25
25662334-3	2015	The iron hormone hepcidin is activated by such stimuli causing degradation of the iron exporter ferroportin and reduced iron release from macrophages, suggesting that hepcidin is the crucial effector of inflammatory hypoferremia.	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	167-175
25662334-3	2015	The iron hormone hepcidin is activated by such stimuli causing degradation of the iron exporter ferroportin and reduced iron release from macrophages, suggesting that hepcidin is the crucial effector of inflammatory hypoferremia.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	17-25
25662334-3	2015	The iron hormone hepcidin is activated by such stimuli causing degradation of the iron exporter ferroportin and reduced iron release from macrophages, suggesting that hepcidin is the crucial effector of inflammatory hypoferremia.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	167-175
25662334-3	2015	The iron hormone hepcidin is activated by such stimuli causing degradation of the iron exporter ferroportin and reduced iron release from macrophages, suggesting that hepcidin is the crucial effector of inflammatory hypoferremia.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	17-25
25662334-3	2015	The iron hormone hepcidin is activated by such stimuli causing degradation of the iron exporter ferroportin and reduced iron release from macrophages, suggesting that hepcidin is the crucial effector of inflammatory hypoferremia.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	167-175
25662334-6	2015	Furthermore, C326S ferroportin mutant mice with a disrupted hepcidin/ferroportin regulatory circuitry respond to injection of the TLR2/6 ligands FSL1 or PAM3CSK4 by ferroportin downregulation and a reduction of serum iron levels.	Iron	217-221	hepcidin antimicrobial peptide	Mus musculus	60-68
25557851-1	2015	beta-thalassemias result from diminished beta-globin synthesis and are associated with ineffective erythropoiesis and secondary iron overload caused by inappropriately low levels of the iron regulatory hormone hepcidin.	Iron	128-132	hepcidin antimicrobial peptide	Mus musculus	210-218
25557851-2	2015	The serine protease TMPRSS6 attenuates hepcidin production in response to iron stores.	Iron	74-78	hepcidin antimicrobial peptide	Mus musculus	39-47
25557851-3	2015	Hepcidin induction reduces iron overload and mitigates anemia in murine models of beta-thalassemia intermedia.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	0-8
25557851-5	2015	We demonstrate that the total body iron burden is markedly improved in Hbb(th3/+) animals treated with siRNA and chelated with oral deferiprone, representing a significant improvement compared to either compound alone.	Iron	35-39	hemoglobin beta chain complex	Mus musculus	71-74
25315005-4	2015	Dietary iron affects circadian glucose metabolism through heme-mediated regulation of the interaction of nuclear receptor subfamily 1 group d member 1 (Rev-Erbalpha) with its cosuppressor nuclear receptor corepressor 1 (NCOR).	Iron	8-12	nuclear receptor subfamily 1, group D, member 1	Mus musculus	105-150
25315005-4	2015	Dietary iron affects circadian glucose metabolism through heme-mediated regulation of the interaction of nuclear receptor subfamily 1 group d member 1 (Rev-Erbalpha) with its cosuppressor nuclear receptor corepressor 1 (NCOR).	Iron	8-12	nuclear receptor subfamily 1, group D, member 1	Mus musculus	152-164
25835049-0	2015	Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.	Iron	33-37	cytochrome b reductase 1	Homo sapiens	0-21
25835049-0	2015	Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.	Iron	33-37	cytochrome b reductase 1	Homo sapiens	23-28
25835049-9	2015	One member of this family; duodenal cytochrome b (DCYTB); may play an important role in ascorbate-dependent reduction of non-heme iron in the gut prior to uptake by ferrous-iron transporters.	Iron	130-134	cytochrome b reductase 1	Homo sapiens	27-48
25835049-9	2015	One member of this family; duodenal cytochrome b (DCYTB); may play an important role in ascorbate-dependent reduction of non-heme iron in the gut prior to uptake by ferrous-iron transporters.	Iron	130-134	cytochrome b reductase 1	Homo sapiens	50-55
25820781-1	2015	Quantum interference is used to measure the spin interactions between an InAs surface electron system and the iron center in the biomolecule hemin in nanometer proximity in a bio-organic/semiconductor device structure.	Iron	110-114	spindlin 1	Homo sapiens	44-48
25820781-6	2015	Spin-flip scattering is found to increase with temperature due to hemin, signifying a spin exchange between the iron center and the electrons, thus implying interactions between a biomolecule and a solid-state system in the hemin/InAs hybrid structure.	Iron	112-116	spindlin 1	Homo sapiens	0-4
25820781-6	2015	Spin-flip scattering is found to increase with temperature due to hemin, signifying a spin exchange between the iron center and the electrons, thus implying interactions between a biomolecule and a solid-state system in the hemin/InAs hybrid structure.	Iron	112-116	spindlin 1	Homo sapiens	86-90
25762074-0	2015	The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.	Iron	4-8	CDGSH iron sulfur domain 2	Homo sapiens	55-60
25762074-6	2015	MAD-28 was found to target the mitochondria of cancer cells and displayed a surprising similarity in its effects to the effects of mNT/NAF-1 shRNA suppression in cancer cells, causing a decrease in respiration and mitochondrial membrane potential, as well as an increase in mitochondrial iron content and glycolysis.	Iron	288-292	CDGSH iron sulfur domain 2	Homo sapiens	135-140
25890235-4	2015	Using neutrophils isolated from the knock-in mice, we identified several PKCdelta substrates, one of which was lipocalin-2 (LCN2), which is an iron-binding protein that can trigger apoptosis by reducing intracellular iron concentrations.	Iron	143-147	protein kinase C, delta	Mus musculus	73-81
25604895-3	2015	Recent data indicate that iron-bearing Kti11 functions as an electron donor to the [4Fe-4S] cluster of radical S-Adenosylmethionine enzymes, triggering the subsequent radical reaction.	Iron	26-30	diphthamide biosynthesis 3	Homo sapiens	39-44
25604895-9	2015	In the complex, Kti13 orients Kti11 and restricts access to its electron-carrying iron atom, constraining the electron transfer capacity of Kti11.	Iron	82-86	Ats1p	Saccharomyces cerevisiae S288C	16-21
25604895-9	2015	In the complex, Kti13 orients Kti11 and restricts access to its electron-carrying iron atom, constraining the electron transfer capacity of Kti11.	Iron	82-86	diphthamide biosynthesis 3	Homo sapiens	30-35
25604895-9	2015	In the complex, Kti13 orients Kti11 and restricts access to its electron-carrying iron atom, constraining the electron transfer capacity of Kti11.	Iron	82-86	diphthamide biosynthesis 3	Homo sapiens	140-145
25318588-12	2015	The increased duodenal DcytB, DMT1, and FPN1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants.	Iron	79-83	cytochrome b reductase 1	Homo sapiens	23-28
25318588-12	2015	The increased duodenal DcytB, DMT1, and FPN1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants.	Iron	112-116	cytochrome b reductase 1	Homo sapiens	23-28
25318588-13	2015	Hepcidin or enterocyte iron levels may be involved in the regulation of age-dependent FPN1, DMT1, and DcytB expression in the duodenum.	Iron	23-27	RoBo-1	Rattus norvegicus	92-96
25213598-8	2015	Furthermore, the serum iron concentration and expression of transferrin, a homeostasis-related iron protein, in the SP were increased relative to non-Tg.	Iron	95-99	transferrin	Mus musculus	60-71
25499799-0	2015	Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson"s disease and aging.	Iron	59-63	monoamine oxidase B	Rattus norvegicus	109-128
26255344-5	2015	During the development of resistance phenotype the tumor tissue also exhibited increased "free iron" concentration that putatively correlate with elevation of ROS generation and levels of MMP-2 and MMP-9 active forms.	Iron	95-99	matrix metallopeptidase 9	Homo sapiens	198-203
25609768-6	2015	This gene encodes the mitochondrial iron-sulfur (Fe/S) protein assembly factor IBA57.	Iron	49-51	iron-sulfur cluster assembly factor IBA57	Homo sapiens	79-84
25519735-1	2015	Under conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic cells.	Iron	176-180	hepcidin antimicrobial peptide	Mus musculus	119-127
25592411-0	2015	Analysis of the C19orf12 and WDR45 genes in patients with neurodegeneration with brain iron accumulation.	Iron	87-91	chromosome 19 open reading frame 12	Homo sapiens	16-24
25499454-2	2015	Nevertheless, TFR2 mutations cause iron overload (hemochromatosis type 3) without overt erythroid abnormalities.	Iron	35-39	transferrin receptor 2	Mus musculus	14-18
25499454-4	2015	Tfr2(BMKO) mice have normal iron parameters, reduced hepcidin levels, higher hemoglobin and red blood cell counts, and lower mean corpuscular volume than normal control mice, a phenotype that becomes more evident in iron deficiency.	Iron	28-32	transferrin receptor 2	Mus musculus	0-4
25499454-9	2015	We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo sensitivity.	Iron	47-51	transferrin receptor 2	Mus musculus	16-20
25499454-9	2015	We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo sensitivity.	Iron	119-123	transferrin receptor 2	Mus musculus	16-20
25651183-0	2015	Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.	Iron	49-53	aconitase 1	Mus musculus	0-25
25264597-10	2015	CONCLUSIONS: Hepatic hepcidin plays an important role in sepsis through regulation of iron metabolism.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	21-29
25554701-0	2015	Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans.	Iron	21-25	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	0-4
25554701-4	2015	The human pathogenic fungus Cryptococcus neoformans possesses an ortholog of S. cerevisiae Leu1, and our previous transcriptome data showed that the expression of LEU1 is regulated by iron availability.	Iron	184-188	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	91-95
25554701-4	2015	The human pathogenic fungus Cryptococcus neoformans possesses an ortholog of S. cerevisiae Leu1, and our previous transcriptome data showed that the expression of LEU1 is regulated by iron availability.	Iron	184-188	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	163-167
25554701-5	2015	In this study, we characterized the role of Leu1 in iron homeostasis and the virulence of C. neoformans.	Iron	52-56	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	44-48
25554701-6	2015	We found that deletion of LEU1 caused leucine auxotrophy and that Leu1 may play a role in the mitochondrial-cytoplasmic Fe-S cluster balance.	Iron	120-124	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	66-70
25554701-7	2015	Whereas cytoplasmic Fe-S protein levels were not affected, mitochondrial Fe-S proteins were up-regulated in the leu1 mutant, suggesting that Leu1 mainly influences mitochondrial iron metabolism.	Iron	178-182	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	112-116
25554701-7	2015	Whereas cytoplasmic Fe-S protein levels were not affected, mitochondrial Fe-S proteins were up-regulated in the leu1 mutant, suggesting that Leu1 mainly influences mitochondrial iron metabolism.	Iron	178-182	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	141-145
25554701-10	2015	Overall, our results indicate that Leu1 plays a role in iron metabolism and is required for virulence in C. neoformans.	Iron	56-60	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	35-39
25425686-1	2015	Mice have been essential for distinguishing the role of hepcidin in iron homeostasis.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	56-64
25425686-8	2015	We demonstrate that serum hepcidin concentrations correlate with liver hepcidin mRNA expression, transferrin saturation and non-heme liver iron.	Iron	139-143	hepcidin antimicrobial peptide	Mus musculus	26-34
25425686-9	2015	In some circumstances, serum hepcidin-1 more accurately predicts iron parameters than hepcidin mRNA, and distinguishes smaller, statistically significant differences between experimental groups.	Iron	65-69	hepcidin antimicrobial peptide	Mus musculus	29-37
25662235-3	2015	Field emission scanning electron microscopy and X-ray diffraction spectroscopy were used to characterize the surface morphology and crystal structure of the Fe-NFM, and demonstrated that Fe-NFM was composed of continuous, randomly distributed uniform nanofibers with surface coating of Fe3O4 nanoparticles.	Iron	157-159	neurofilament medium chain	Homo sapiens	160-163
25662235-3	2015	Field emission scanning electron microscopy and X-ray diffraction spectroscopy were used to characterize the surface morphology and crystal structure of the Fe-NFM, and demonstrated that Fe-NFM was composed of continuous, randomly distributed uniform nanofibers with surface coating of Fe3O4 nanoparticles.	Iron	157-159	neurofilament medium chain	Homo sapiens	190-193
25662235-3	2015	Field emission scanning electron microscopy and X-ray diffraction spectroscopy were used to characterize the surface morphology and crystal structure of the Fe-NFM, and demonstrated that Fe-NFM was composed of continuous, randomly distributed uniform nanofibers with surface coating of Fe3O4 nanoparticles.	Iron	187-189	neurofilament medium chain	Homo sapiens	190-193
25662235-4	2015	A series of adsorption experiments were carried out to evaluate the removal efficiency of TC by the Fe-NFM.	Iron	100-102	neurofilament medium chain	Homo sapiens	103-106
25511817-5	2015	LCN2 induces chemokine production in the CNS in response to inflammatory challenges, and actively participates in the innate immune response, cellular influx of iron, and regulation of neuroinflammation and neurodegeneration.	Iron	161-165	lipocalin 2	Homo sapiens	0-4
25600293-7	2015	Mutation of the iron-binding motifs in Apd1p abrogated its ability to rescue HU sensitivity in apd1Delta cells.	Iron	16-20	Apd1p	Saccharomyces cerevisiae S288C	39-44
25600293-8	2015	The iron-binding activity of Apd1p was verified by a color assay.	Iron	4-8	Apd1p	Saccharomyces cerevisiae S288C	29-34
25600293-9	2015	By mass spectrometry two irons were found to be incorporated into one Apd1p protein molecule.	Iron	25-30	Apd1p	Saccharomyces cerevisiae S288C	70-75
25590758-3	2015	Additionally, timely administration of hepcidin agonists to hepcidin-deficient mice induces hypoferremia that decreases bacterial loads and rescues these mice from death, regardless of initial iron levels.	Iron	193-197	hepcidin antimicrobial peptide	Mus musculus	39-47
25590758-4	2015	Studies of Vibrio vulnificus growth ex vivo show that high iron sera from hepcidin-deficient mice support extraordinarily rapid bacterial growth and that this is inhibited in hypoferremic sera.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	74-82
28962376-2	2015	In the liver, it cleaves prohepcidin to form active hepcidin-25, which regulates systemic iron homeostasis.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	28-36
28962376-4	2015	Several studies have identified factors that repress hepcidin gene transcription in iron overload.	Iron	84-88	hepcidin antimicrobial peptide	Mus musculus	53-61
28962376-5	2015	However, the effect of iron overload on furin, a post-translational regulator of hepcidin, has never been evaluated.	Iron	23-27	hepcidin antimicrobial peptide	Mus musculus	81-89
28962376-11	2015	The hepcidin gene (hepcidin antimicrobial peptide gene, Hamp1) expression was increased in iron-overloaded WT and th3/+ mice.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	4-12
28962376-11	2015	The hepcidin gene (hepcidin antimicrobial peptide gene, Hamp1) expression was increased in iron-overloaded WT and th3/+ mice.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	19-49
28962376-11	2015	The hepcidin gene (hepcidin antimicrobial peptide gene, Hamp1) expression was increased in iron-overloaded WT and th3/+ mice.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	56-61
25569627-1	2015	Hepcidin is a key hormone that induces the degradation of ferroportin (FPN), a protein that exports iron from reticuloendothelial macrophages and enterocytes.	Iron	100-104	hepcidin antimicrobial peptide	Mus musculus	0-8
25569627-10	2015	Possible explanations for the increased hepcidin expression observed in HFD animals may include: increased leptin levels, the liver iron accumulation or endoplasmic reticulum (ER) stress.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	40-48
25205713-1	2015	Matriptase-2 is a type II transmembrane serine protease controlling the expression of hepcidin, the key regulator of iron homeostasis.	Iron	117-121	hepcidin antimicrobial peptide	Mus musculus	86-94
25205713-12	2015	These findings implicate a role of fetuin-A in iron homeostasis and provide new insights into the mechanism of how matriptase-2 might modulate hepcidin expression.	Iron	47-51	alpha-2-HS-glycoprotein	Mus musculus	35-43
25460199-0	2015	Hepatic nerve growth factor induced by iron overload triggers defenestration in liver sinusoidal endothelial cells.	Iron	39-43	nerve growth factor	Mus musculus	8-27
25460199-3	2015	In this study, we found a novel link between LSEC defenestration and hepatic nerve growth factor (NGF) in iron-overloaded mice.	Iron	106-110	nerve growth factor	Mus musculus	77-96
25460199-3	2015	In this study, we found a novel link between LSEC defenestration and hepatic nerve growth factor (NGF) in iron-overloaded mice.	Iron	106-110	nerve growth factor	Mus musculus	98-101
25460199-9	2015	In conclusion, iron accumulation induces NGF expression in hepatocytes, which in turn leads to LSEC defenestration via TrkA.	Iron	15-19	nerve growth factor	Mus musculus	41-44
25460199-10	2015	This novel link between iron and NGF may aid our understanding of the development of chronic liver disease.	Iron	24-28	nerve growth factor	Mus musculus	33-36
26111426-1	2015	Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery, inflammation, insulin resistance, and tissue regeneration.	Iron	154-158	lipocalin 2	Homo sapiens	0-11
26111426-1	2015	Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery, inflammation, insulin resistance, and tissue regeneration.	Iron	154-158	lipocalin 2	Homo sapiens	13-17
25114080-5	2015	Through one pathway, HO-1 promotes the expression of CDK5 by accumulating reactive oxygen species, which are produced by HO-1 downstream products of iron in neuro2a cell lines and mouse brain.	Iron	149-153	cyclin-dependent kinase 5	Mus musculus	53-57
24854990-10	2015	Our studies suggest that SF3B1 mutations contribute to cellular iron overload in RARS/-T by deregulating SLC25A37.	Iron	64-68	solute carrier family 25 member 37	Homo sapiens	105-113
26551233-1	2015	BACKGROUND/AIM: Dietary phosphate intake and vitamin D receptor activator (VDRA) regulate fibroblast growth factor 23 (FGF23); iron may modulate FGF23 metabolism.	Iron	127-131	fibroblast growth factor 23	Homo sapiens	145-150
26551233-2	2015	We aimed to determine whether oral iron supplementation influences serum FGF23 concentration in hemodialysis (HD) patients, while excluding the effect of dietary phosphate intake.	Iron	35-39	fibroblast growth factor 23	Homo sapiens	73-78
25566293-6	2014	The ABA-decreased Cd uptake was found to correlate with the ABA-inhibited IRT1 expression in the roots of Col-0 plants fed two different levels of iron.	Iron	147-151	iron-regulated transporter 1	Arabidopsis thaliana	74-78
25566293-9	2014	Interestingly, ABA application increased the iron level in both Col-0 plants and irt1 mutants, suggesting that ABA-increased Fe acquisition does not depend on the IRT1 function, but on the contrary, the ABA-mediated inhibition of IRT1 expression may be due to the elevation of iron level in plants.	Iron	45-49	iron-regulated transporter 1	Arabidopsis thaliana	81-85
25566293-9	2014	Interestingly, ABA application increased the iron level in both Col-0 plants and irt1 mutants, suggesting that ABA-increased Fe acquisition does not depend on the IRT1 function, but on the contrary, the ABA-mediated inhibition of IRT1 expression may be due to the elevation of iron level in plants.	Iron	125-127	iron-regulated transporter 1	Arabidopsis thaliana	81-85
25566293-9	2014	Interestingly, ABA application increased the iron level in both Col-0 plants and irt1 mutants, suggesting that ABA-increased Fe acquisition does not depend on the IRT1 function, but on the contrary, the ABA-mediated inhibition of IRT1 expression may be due to the elevation of iron level in plants.	Iron	277-281	iron-regulated transporter 1	Arabidopsis thaliana	230-234
25504720-3	2014	We show that the iron transport protein transferrin is engaged in ancient and ongoing evolutionary conflicts with TbpA, a transferrin surface receptor from bacteria.	Iron	17-21	transthyretin	Homo sapiens	114-118
25504720-4	2014	Single substitutions in transferrin at rapidly evolving sites reverse TbpA binding, providing a mechanism to counteract bacterial iron piracy among great apes.	Iron	130-134	transthyretin	Homo sapiens	70-74
25239763-0	2014	Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons.	Iron	98-102	brain derived neurotrophic factor	Homo sapiens	0-33
25241290-1	2014	Hepcidin is a peptide hormone that controls systemic iron availability and is upregulated by iron and inflammation.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	0-8
25241290-1	2014	Hepcidin is a peptide hormone that controls systemic iron availability and is upregulated by iron and inflammation.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	0-8
25065856-0	2014	Growth differentiation factor-15 in young sickle cell disease patients: relation to hemolysis, iron overload and vascular complications.	Iron	95-99	growth differentiation factor 15	Homo sapiens	0-32
25065856-1	2014	BACKGROUND: High expression of growth differentiation factor-15 (GDF-15) contributes to pathological iron overload in thalassemia.	Iron	101-105	growth differentiation factor 15	Homo sapiens	31-63
25065856-1	2014	BACKGROUND: High expression of growth differentiation factor-15 (GDF-15) contributes to pathological iron overload in thalassemia.	Iron	101-105	growth differentiation factor 15	Homo sapiens	65-71
25065856-3	2014	AIM: To determine serum GDF-15 in 35 children and adolescents with sickle cell disease (SCD) compared to 35 healthy controls and assess its relation to markers of hemolysis, iron overload and vascular complications.	Iron	174-178	growth differentiation factor 15	Homo sapiens	24-30
25065856-10	2014	GDF-15 levels are related to hemolysis and iron overload and may provide utility for identifying patients at increased risk of thrombotic events.	Iron	43-47	growth differentiation factor 15	Homo sapiens	0-6
25220979-3	2014	In hemojuvelin-knockout mice, a model of the disease, males load more cardiac iron than females.	Iron	78-82	hemojuvelin BMP co-receptor	Mus musculus	3-14
24580532-2	2014	Lipocalin 2 (Lcn2) is an iron-sequestering protein in the antibacterial innate immune response, which inhibit bacterial growth.	Iron	25-29	lipocalin 2	Homo sapiens	0-11
24580532-2	2014	Lipocalin 2 (Lcn2) is an iron-sequestering protein in the antibacterial innate immune response, which inhibit bacterial growth.	Iron	25-29	lipocalin 2	Homo sapiens	13-17
25477872-6	2014	Experimental published data and STRING analysis of common TSPO partners in fluorescent Pseudomonas indicate a potential role of TSPO in the oxidative stress response, iron homeostasis and virulence expression.	Iron	167-171	translocator protein	Homo sapiens	58-62
25477872-6	2014	Experimental published data and STRING analysis of common TSPO partners in fluorescent Pseudomonas indicate a potential role of TSPO in the oxidative stress response, iron homeostasis and virulence expression.	Iron	167-171	translocator protein	Homo sapiens	128-132
25300486-4	2014	Aft1 regulates iron homeostasis and is also involved in genome integrity having additional iron-independent functions.	Iron	15-19	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
25300486-4	2014	Aft1 regulates iron homeostasis and is also involved in genome integrity having additional iron-independent functions.	Iron	91-95	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
25387073-4	2014	Mx IRT1 could rescue the iron-deficiency phenotype of an Arabidopsis irt1 mutant, and complement the iron-limited growth defect of the yeast mutant DEY 1453 (fet3fet4).	Iron	25-29	iron-regulated transporter 1	Arabidopsis thaliana	3-7
24983770-7	2014	Additionally, overexpression of FTL decreased the LPS-induced increase of the intracellular labile iron pool (LIP) and reactive oxygen species (ROS).	Iron	99-103	ferritin light polypeptide 1	Mus musculus	32-35
25332466-2	2014	Bean iron concentration has been doubled by selective plant breeding, but the additional iron is reported to be of low bioavailability, most likely due to high phytic acid (PA) concentrations.	Iron	5-9	brain expressed associated with NEDD4 1	Homo sapiens	0-4
25332466-8	2014	The quantity of iron absorbed from the biofortified bean meals (406 mug) was 19% higher (P &lt; 0.05) than that from the control bean meals.	Iron	16-20	brain expressed associated with NEDD4 1	Homo sapiens	52-56
25332466-9	2014	With ~50% and &gt;95% dephytinization, the quantity of iron absorbed from the biofortified bean meals increased to 599 and 746 mug, respectively, which was 37% (P &lt; 0.005) and 51% (P &lt; 0.0001) higher than from the control bean meals.	Iron	55-59	brain expressed associated with NEDD4 1	Homo sapiens	91-95
25332466-9	2014	With ~50% and &gt;95% dephytinization, the quantity of iron absorbed from the biofortified bean meals increased to 599 and 746 mug, respectively, which was 37% (P &lt; 0.005) and 51% (P &lt; 0.0001) higher than from the control bean meals.	Iron	55-59	brain expressed associated with NEDD4 1	Homo sapiens	228-232
25332466-10	2014	CONCLUSIONS: PA strongly decreases iron bioavailability from iron-biofortified beans, and a high PA concentration is an important impediment to the optimal effectiveness of bean iron biofortification.	Iron	35-39	brain expressed associated with NEDD4 1	Homo sapiens	79-83
25332466-10	2014	CONCLUSIONS: PA strongly decreases iron bioavailability from iron-biofortified beans, and a high PA concentration is an important impediment to the optimal effectiveness of bean iron biofortification.	Iron	61-65	brain expressed associated with NEDD4 1	Homo sapiens	79-83
25332466-10	2014	CONCLUSIONS: PA strongly decreases iron bioavailability from iron-biofortified beans, and a high PA concentration is an important impediment to the optimal effectiveness of bean iron biofortification.	Iron	61-65	brain expressed associated with NEDD4 1	Homo sapiens	79-83
25332470-6	2014	RESULTS: High iron loading increased hepatic hepcidin by 3-fold and reduced duodenal expression of divalent metal transporter 1 (DMT1) by 76%.	Iron	14-18	RoBo-1	Rattus norvegicus	99-127
25332470-6	2014	RESULTS: High iron loading increased hepatic hepcidin by 3-fold and reduced duodenal expression of divalent metal transporter 1 (DMT1) by 76%.	Iron	14-18	RoBo-1	Rattus norvegicus	129-133
25558243-0	2014	Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake.	Iron	85-89	sirtuin 2	Rattus norvegicus	14-23
25360591-2	2014	With the goal of improving the iron (Fe) storage properties of plants, we have investigated the function of three Arabidopsis proteins with homology to Vacuolar Iron Transporter1 (AtVIT1).	Iron	31-35	vacuolar iron transporter 1	Arabidopsis thaliana	180-186
25360591-2	2014	With the goal of improving the iron (Fe) storage properties of plants, we have investigated the function of three Arabidopsis proteins with homology to Vacuolar Iron Transporter1 (AtVIT1).	Iron	37-39	vacuolar iron transporter 1	Arabidopsis thaliana	180-186
25360591-6	2014	Seedling root growth of the Arabidopsis nramp3/nramp4 and vit1-1 mutants was decreased compared to the wild type when seedlings were grown under Fe deficiency.	Iron	145-147	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	40-46
25360591-6	2014	Seedling root growth of the Arabidopsis nramp3/nramp4 and vit1-1 mutants was decreased compared to the wild type when seedlings were grown under Fe deficiency.	Iron	145-147	vacuolar iron transporter 1	Arabidopsis thaliana	58-64
25360591-8	2014	The seed Fe concentration in the nramp3/nramp4 mutant overexpressing AtVTL1, AtVTL2 or AtVTL5 was between 50 and 60% higher than in non-transformed double mutants or wild-type plants.	Iron	9-11	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	33-39
25360591-8	2014	The seed Fe concentration in the nramp3/nramp4 mutant overexpressing AtVTL1, AtVTL2 or AtVTL5 was between 50 and 60% higher than in non-transformed double mutants or wild-type plants.	Iron	9-11	natural resistance associated macrophage protein 4	Arabidopsis thaliana	40-46
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	157-160
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	162-167
25352340-3	2014	We find 11 genome-wide-significant (P&lt;5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).	Iron	80-84	N-acetyltransferase 2	Homo sapiens	176-180
25310285-7	2014	The drop in iron content was accompanied by the upregulation of the gene encoding for FERRIC REDUCTION OXIDASE 6 (FRO6) in mutant seedlings but not by the differential expression of other transport genes known to be induced by iron deficiency.	Iron	12-16	ferric reduction oxidase 6	Arabidopsis thaliana	86-112
25027680-5	2014	The obtained results showed only one statistically significant difference between ES and N groups, namely a higher level of Fe was noticed in CA3 region in the kindled animals.	Iron	124-126	carbonic anhydrase 3	Rattus norvegicus	142-145
24833525-4	2014	The results indicate that P retention by CFH is due to surface complexation by rapid formation of strong Fe-P bonds.	Iron	105-107	complement factor H	Homo sapiens	41-44
25380917-2	2014	However, it should be remembered that NGAL is involved in iron metabolism and antimicrobial defense mechanisms.	Iron	58-62	lipocalin 2	Homo sapiens	38-42
25380934-0	2014	Growth differentiation factor 15 is related to anemia and iron metabolism in heart allograft recipients and patients with chronic heart failure.	Iron	58-62	growth differentiation factor 15	Homo sapiens	0-32
25380934-3	2014	The aim of this study was to assess GDF15 levels and its correlation with iron parameters in 134 stable heart transplant recipients compared with 157 patients with chronic heart failure (CHF).	Iron	74-78	growth differentiation factor 15	Homo sapiens	36-41
25380934-11	2014	In univariate analysis in CHF patients, GDF15 was related to creatinine, erythrocyte count, hemoglobin, hepcidin, and total iron binding capacity and tended to correlate with EF.	Iron	124-128	growth differentiation factor 15	Homo sapiens	40-45
25380934-13	2014	CONCLUSIONS: GDF15, by affecting iron status, might be involved in the pathogenesis of anemia in patients with cardiovascular pathology.	Iron	33-37	growth differentiation factor 15	Homo sapiens	13-18
24767084-5	2014	The allosteric (or cooperative) inhibition of soybean lipoxygenase-1 of longer alkyl protocatechuates is reversible but in combination with their iron binding ability to disrupt the active site competitively and to interact with the hydrophobic portion surrounding near the active site (sequential action).	Iron	146-150	linoleate 9S-lipoxygenase-4	Glycine max	54-66
25183762-9	2014	Incubation with 5.0 mM deferoxamine (an iron chelator) reduced IRBP-dependent 11-cis retinol retrieval by 60%.	Iron	40-44	retinol binding protein 3	Rattus norvegicus	63-67
25195888-1	2014	The chloroplastic Arabidopsis thaliana Nfs2 (AtNfs2) is a group II pyridoxal 5"-phosphate-dependent cysteine desulfurase that is involved in the initial steps of iron-sulfur cluster biogenesis.	Iron	162-166	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	39-43
25195888-1	2014	The chloroplastic Arabidopsis thaliana Nfs2 (AtNfs2) is a group II pyridoxal 5"-phosphate-dependent cysteine desulfurase that is involved in the initial steps of iron-sulfur cluster biogenesis.	Iron	162-166	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	45-51
24816174-0	2014	Hepcidin knockout mice fed with iron-rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	0-8
24816174-0	2014	Hepcidin knockout mice fed with iron-rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	0-8
24816174-1	2014	BACKGROUND &amp; AIMS: Hepcidin is the central regulator of iron homeostasis and altered hepcidin signalling results in both hereditary and acquired iron overload.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	23-31
24816174-1	2014	BACKGROUND &amp; AIMS: Hepcidin is the central regulator of iron homeostasis and altered hepcidin signalling results in both hereditary and acquired iron overload.	Iron	149-153	hepcidin antimicrobial peptide	Mus musculus	23-31
24816174-1	2014	BACKGROUND &amp; AIMS: Hepcidin is the central regulator of iron homeostasis and altered hepcidin signalling results in both hereditary and acquired iron overload.	Iron	149-153	hepcidin antimicrobial peptide	Mus musculus	89-97
24816174-7	2014	RESULTS: Among mice kept on iron-rich diet, 6 months old hepcidin KO mice (vs. WT) displayed profound hepatic iron overload (3,186 +- 411 vs. 1,045 +- 159 mug/mg tissue, p&lt;0.005), elevated liver enzymes (ALT: KO 128 +- 6, WT 56 +- 5 IU/L, p&lt;0.05), mild hepatic inflammation and hepatocellular apoptosis.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	57-65
24816174-7	2014	RESULTS: Among mice kept on iron-rich diet, 6 months old hepcidin KO mice (vs. WT) displayed profound hepatic iron overload (3,186 +- 411 vs. 1,045 +- 159 mug/mg tissue, p&lt;0.005), elevated liver enzymes (ALT: KO 128 +- 6, WT 56 +- 5 IU/L, p&lt;0.05), mild hepatic inflammation and hepatocellular apoptosis.	Iron	110-114	hepcidin antimicrobial peptide	Mus musculus	57-65
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	35-39	iron-regulated transporter 1	Arabidopsis thaliana	85-89
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	35-39	ferric reduction oxidase 5	Arabidopsis thaliana	97-101
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	35-39	basic helix-loop-helix protein 100	Arabidopsis thaliana	103-110
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	41-43	iron-regulated transporter 1	Arabidopsis thaliana	85-89
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	41-43	ferric reduction oxidase 5	Arabidopsis thaliana	97-101
24928490-7	2014	Interestingly, 23 genes related to iron (Fe) acquisition were up-regulated including IRT1, YSL2, FRO5, BHLH100, BHLH101 and BHLH039 and the master controllers of Fe deficiency responses PYE and BTS were specifically activated in pericycle cells.	Iron	41-43	basic helix-loop-helix protein 100	Arabidopsis thaliana	103-110
25002578-1	2014	Systemic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally regulated by the bone morphogenetic protein (BMP)-SMAD pathway.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	65-73
25002578-2	2014	In iron deficiency, liver BMP-SMAD signaling and hepcidin are suppressed as a compensatory mechanism to increase iron availability.	Iron	3-7	hepcidin antimicrobial peptide	Mus musculus	49-57
25002578-10	2014	Our data suggest that iron deficiency increases liver miR-130a, which, by targeting ALK2, may contribute to reduce BMP-SMAD signaling, suppress hepcidin synthesis, and thereby promote iron availability.	Iron	22-26	activin A receptor, type 1	Mus musculus	84-88
25002578-10	2014	Our data suggest that iron deficiency increases liver miR-130a, which, by targeting ALK2, may contribute to reduce BMP-SMAD signaling, suppress hepcidin synthesis, and thereby promote iron availability.	Iron	22-26	hepcidin antimicrobial peptide	Mus musculus	144-152
25117470-4	2014	As shown by a comparative two dimensional difference gel electrophoresis (2D-DIGE) approach combined with mass spectrometry, particularly two groups of proteins were affected: the iron-sulfur containing aconitase-type proteins (Aco1p, Lys4p) and the lipoamide-containing subproteome (Lat1p, Kgd2p and Gcv3p).	Iron	180-184	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	228-233
25117470-4	2014	As shown by a comparative two dimensional difference gel electrophoresis (2D-DIGE) approach combined with mass spectrometry, particularly two groups of proteins were affected: the iron-sulfur containing aconitase-type proteins (Aco1p, Lys4p) and the lipoamide-containing subproteome (Lat1p, Kgd2p and Gcv3p).	Iron	180-184	alpha-ketoglutarate dehydrogenase KGD2	Saccharomyces cerevisiae S288C	291-296
25117470-4	2014	As shown by a comparative two dimensional difference gel electrophoresis (2D-DIGE) approach combined with mass spectrometry, particularly two groups of proteins were affected: the iron-sulfur containing aconitase-type proteins (Aco1p, Lys4p) and the lipoamide-containing subproteome (Lat1p, Kgd2p and Gcv3p).	Iron	180-184	glycine decarboxylase subunit H	Saccharomyces cerevisiae S288C	301-306
25117470-7	2014	We propose a regulatory role of Sat4p in the late steps of the maturation of a specific subset of mitochondrial iron-sulfur cluster proteins, including Aco1p and lipoate synthase Lip5p.	Iron	112-116	serine/threonine protein kinase SAT4	Saccharomyces cerevisiae S288C	32-37
25117470-7	2014	We propose a regulatory role of Sat4p in the late steps of the maturation of a specific subset of mitochondrial iron-sulfur cluster proteins, including Aco1p and lipoate synthase Lip5p.	Iron	112-116	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	152-157
24954417-0	2014	The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.	Iron	60-64	Succinate dehydrogenase assembly factor 3	Drosophila melanogaster	27-33
24833704-10	2014	The rapid induction of short-acting mucosal block only in iron-deficient rats suggests DMT1 internalization.	Iron	58-62	RoBo-1	Rattus norvegicus	87-91
25364361-3	2014	In addition, NGAL was studied as an iron regulatory glycoprotein and regulator of iron related gene.	Iron	36-40	lipocalin 2	Homo sapiens	13-17
25364361-4	2014	The aim of the current study was to determine any association between serum NGAL and body iron status markers in children on chronic dialysis.	Iron	90-94	lipocalin 2	Homo sapiens	76-80
24880340-2	2014	After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	61-69
24880340-6	2014	ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.	Iron	154-158	hemoglobin beta chain complex	Mus musculus	40-43
24982634-6	2014	Though the physiological significance of IRP1 had been unclear since Irp1 (-/-) animals were first assessed in the early 1990s, recent studies indicate that IRP1 plays an essential function in orchestrating the balance between erythropoiesis and bodily iron homeostasis.	Iron	253-257	aconitase 1	Mus musculus	157-161
24982634-7	2014	Additionally, Irp1 (-/-) mice develop pulmonary hypertension, and they experience sudden death when maintained on an iron-deficient diet, indicating that IRP1 has a critical role in the pulmonary and cardiovascular systems.	Iron	117-121	aconitase 1	Mus musculus	14-18
24982634-7	2014	Additionally, Irp1 (-/-) mice develop pulmonary hypertension, and they experience sudden death when maintained on an iron-deficient diet, indicating that IRP1 has a critical role in the pulmonary and cardiovascular systems.	Iron	117-121	aconitase 1	Mus musculus	154-158
24778179-3	2014	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo, given that mice lacking FBXL5 die during early embryogenesis as a result of unrestrained IRP2 activity and oxidative stress attributable to excessive iron accumulation.	Iron	46-50	iron responsive element binding protein 2	Mus musculus	10-14
24778179-3	2014	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo, given that mice lacking FBXL5 die during early embryogenesis as a result of unrestrained IRP2 activity and oxidative stress attributable to excessive iron accumulation.	Iron	221-225	iron responsive element binding protein 2	Mus musculus	10-14
24896637-1	2014	Iron Regulatory Protein 2 (Irp2, Ireb2) is a central regulator of cellular iron homeostasis in vertebrates.	Iron	75-79	iron responsive element binding protein 2	Mus musculus	0-25
24896637-1	2014	Iron Regulatory Protein 2 (Irp2, Ireb2) is a central regulator of cellular iron homeostasis in vertebrates.	Iron	75-79	iron responsive element binding protein 2	Mus musculus	27-31
24896637-1	2014	Iron Regulatory Protein 2 (Irp2, Ireb2) is a central regulator of cellular iron homeostasis in vertebrates.	Iron	75-79	iron responsive element binding protein 2	Mus musculus	33-38
24896637-2	2014	Two global knockout mouse models have been generated to explore the role of Irp2 in regulating iron metabolism.	Iron	95-99	iron responsive element binding protein 2	Mus musculus	76-80
24896637-3	2014	While both mouse models show that loss of Irp2 results in microcytic anemia and altered body iron distribution, discrepant results have drawn into question the role of Irp2 in regulating brain iron metabolism.	Iron	93-97	iron responsive element binding protein 2	Mus musculus	42-46
24896637-9	2014	Our aged Irp2-/- mice show marked iron deposition in white matter and in oligodendrocytes while iron content is significantly reduced in neurons.	Iron	34-38	iron responsive element binding protein 2	Mus musculus	9-13
24896637-9	2014	Our aged Irp2-/- mice show marked iron deposition in white matter and in oligodendrocytes while iron content is significantly reduced in neurons.	Iron	96-100	iron responsive element binding protein 2	Mus musculus	9-13
24652331-4	2014	Serum iron and ferritin as well as iron contents in liver and femur were significantly increased in Hepc1(-/-) mice compared to WT mice.	Iron	6-10	hepcidin antimicrobial peptide	Mus musculus	100-105
24652331-4	2014	Serum iron and ferritin as well as iron contents in liver and femur were significantly increased in Hepc1(-/-) mice compared to WT mice.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	100-105
24658816-2	2014	Hepatic TFR2, together with HFE, activates the transcription of the iron-regulator hepcidin, while erythroid TFR2 is a member of the erythropoietin receptor complex.	Iron	68-72	transferrin receptor 2	Mus musculus	8-12
24658816-2	2014	Hepatic TFR2, together with HFE, activates the transcription of the iron-regulator hepcidin, while erythroid TFR2 is a member of the erythropoietin receptor complex.	Iron	68-72	homeostatic iron regulator	Mus musculus	28-31
24658816-2	2014	Hepatic TFR2, together with HFE, activates the transcription of the iron-regulator hepcidin, while erythroid TFR2 is a member of the erythropoietin receptor complex.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	83-91
24658816-3	2014	The TMPRSS6 gene, encoding the liver-expressed serine protease matriptase-2, is the main inhibitor of hepcidin and inactivation of TMPRSS6 leads to iron deficiency with high hepcidin levels.	Iron	148-152	hepcidin antimicrobial peptide	Mus musculus	102-110
24658816-3	2014	The TMPRSS6 gene, encoding the liver-expressed serine protease matriptase-2, is the main inhibitor of hepcidin and inactivation of TMPRSS6 leads to iron deficiency with high hepcidin levels.	Iron	148-152	hepcidin antimicrobial peptide	Mus musculus	174-182
24658816-9	2014	In addition Tfr2 deletion causes a relative erythrocytosis in iron-deficient mice, which likely attenuates the effect of over-expression of hepcidin in Tmprss6(-/-) mice.	Iron	62-66	transferrin receptor 2	Mus musculus	12-16
24658816-11	2014	We propose that TFR2 is a limiting factor for erythropoiesis, particularly in conditions of iron restriction.	Iron	92-96	transferrin receptor 2	Mus musculus	16-20
24850829-2	2014	Therefore the expression of the different divalent metal transporter 1 (Dmt1) isoforms and ferritin (Ft) subunits, responsible for iron import and chelation, was analyzed under pro-inflammatory conditions (IL1beta alone or together with TNFalpha+IFNgamma).	Iron	131-135	RoBo-1	Rattus norvegicus	42-70
24746831-0	2014	Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	63-71
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	130-138
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Iron	72-76	hepcidin antimicrobial peptide	Mus musculus	130-138
24277523-4	2014	This study aimed to investigate the role and mechanism of microglial beta-nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) activation in iron-induced selective and progressive dopaminergic neurodegeneration.	Iron	149-153	cytochrome b-245 beta chain	Rattus norvegicus	69-127
24277523-4	2014	This study aimed to investigate the role and mechanism of microglial beta-nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) activation in iron-induced selective and progressive dopaminergic neurodegeneration.	Iron	149-153	cytochrome b-245 beta chain	Rattus norvegicus	129-133
24728987-8	2014	IRP1/IRE-RNA complex has a much shorter life-time than the eIF4F/IRE-RNA complex, which suggests that both rate of assembly and stability of the complexes are important, and that allows this regulatory system to respond rapidly to change in cellular iron.	Iron	250-254	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	59-64
24549883-3	2014	Here, we examined whether four of the subgroup Ib basic helix-loop-helix transcription factors (bHLH38, bHLH39, bHLH100, bHLH101), previously implicated in iron homeostasis in roots, also play a role in regulating iron metabolism in developing leaves.	Iron	156-160	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	96-102
24549883-3	2014	Here, we examined whether four of the subgroup Ib basic helix-loop-helix transcription factors (bHLH38, bHLH39, bHLH100, bHLH101), previously implicated in iron homeostasis in roots, also play a role in regulating iron metabolism in developing leaves.	Iron	156-160	basic helix-loop-helix protein 100	Arabidopsis thaliana	112-119
24549883-3	2014	Here, we examined whether four of the subgroup Ib basic helix-loop-helix transcription factors (bHLH38, bHLH39, bHLH100, bHLH101), previously implicated in iron homeostasis in roots, also play a role in regulating iron metabolism in developing leaves.	Iron	214-218	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	96-102
24549883-8	2014	When grown in agar plates with reduced iron concentration, triple bhlh39 bhlh100 bhlh101 mutant plants were smaller than wild-type plants.	Iron	39-43	basic helix-loop-helix protein 100	Arabidopsis thaliana	73-80
24785462-2	2014	We discovered that glucose oxidase (GOx), the enzyme broadly used in enzyme-linked immunosorbent assay (ELISA), has the ability to stimulate in situ formation of squaric acid (SQA)-iron(III) chelate.	Iron	181-185	hydroxyacid oxidase 1	Homo sapiens	19-34
24785462-2	2014	We discovered that glucose oxidase (GOx), the enzyme broadly used in enzyme-linked immunosorbent assay (ELISA), has the ability to stimulate in situ formation of squaric acid (SQA)-iron(III) chelate.	Iron	181-185	hydroxyacid oxidase 1	Homo sapiens	36-39
24785462-6	2014	On the basis of the SQA-iron(III) system, a new immunoassay protocol with GOx-labeled anti-PSA detection antibody can be designed for the detection of target PSA on capture antibody-functionalized magnetic immunosensing probe, monitored by recording the color or absorbance (lambda = 468 nm) of the generated SQA-iron(III) chelate.	Iron	24-28	hydroxyacid oxidase 1	Homo sapiens	74-77
24389061-4	2014	Accompanying the sandwiched immunocomplex, the conjugated GOx could catalyze the oxidation of glucose, simultaneously resulting in the conversion of [Fe(CN)6](3-) to [Fe(CN)6](4-).	Iron	150-152	hydroxyacid oxidase 1	Homo sapiens	58-61
24812553-1	2014	PURPOSE: Loss-of-function mutations in hemojuvelin (HJV) cause juvenile hemochromatosis, an iron-overload disease.	Iron	92-96	hemojuvelin BMP co-receptor	Mus musculus	39-50
24812553-1	2014	PURPOSE: Loss-of-function mutations in hemojuvelin (HJV) cause juvenile hemochromatosis, an iron-overload disease.	Iron	92-96	hemojuvelin BMP co-receptor	Mus musculus	52-55
24812553-2	2014	Deletion of Hjv in mice results in excessive iron accumulation and morphologic changes in the retina.	Iron	45-49	hemojuvelin BMP co-receptor	Mus musculus	12-15
24623103-5	2014	Mossbauer, X-ray diffraction and NMR studies show the iron species to contain low spin Fe(ii), but with evidence of back donation from iron to the pincer ligands.	Iron	54-58	spindlin 1	Homo sapiens	82-86
24714526-4	2014	During chronic iron/heme deficiency in vivo, this HRI-eIF2alphaP-ATF4 signaling is necessary both to reduce oxidative stress and to promote erythroid differentiation.	Iron	15-19	activating transcription factor 4	Homo sapiens	65-69
24569067-4	2014	Chronic alcohol (30% of total calories) or iron (0.2%)-fed adult male C57BL/J mice for 15 weeks resulted in significantly elevated levels of hepatic iron, labile iron pool-Fe and serum non-transferrin bound iron, accompanied with sustained oxidative damage.	Iron	43-47	transferrin	Mus musculus	189-200
24647386-5	2014	Plasma RBP4 concentration was significantly associated with dietary heme iron intake, plasma ferritin concentration, and other established risk factors.	Iron	73-77	retinol binding protein 4	Homo sapiens	7-11
24705334-2	2014	FRDA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters.	Iron	132-136	frataxin	Mus musculus	36-44
24705334-2	2014	FRDA is caused by reduced levels of frataxin (FXN), an essential mitochondrial protein involved in the biosynthesis of iron-sulfur (Fe-S) clusters.	Iron	132-136	frataxin	Mus musculus	46-49
24705334-3	2014	Impaired mitochondrial oxidative phosphorylation, bioenergetics imbalance, deficit of Fe-S cluster enzymes and mitochondrial iron overload occur in the myocardium of individuals with FRDA.	Iron	86-90	frataxin	Mus musculus	183-187
24705334-3	2014	Impaired mitochondrial oxidative phosphorylation, bioenergetics imbalance, deficit of Fe-S cluster enzymes and mitochondrial iron overload occur in the myocardium of individuals with FRDA.	Iron	125-129	frataxin	Mus musculus	183-187
24616218-0	2014	Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload.	Iron	147-151	vitronectin	Homo sapiens	46-57
24616218-5	2014	Computational analysis of proteomic dataset highlighted the hepatocytic vitronectin expression as the most promising specific biomarker for iron-associated fibrogenesis in HCV infections.	Iron	140-144	vitronectin	Homo sapiens	72-83
24616218-6	2014	Next, the robustness of our in vitro findings was challenged in human liver biopsies by immunohistochemistry and yielded two major results: (i) hepatocytic vitronectin expression is associated to liver fibrogenesis in HCV-infected patients with iron overload; (ii) hepatic vitronectin expression was found to discriminate also the transition between mild to moderate fibrosis in HCV-infected patients without iron overload.	Iron	245-249	vitronectin	Homo sapiens	156-167
24616218-6	2014	Next, the robustness of our in vitro findings was challenged in human liver biopsies by immunohistochemistry and yielded two major results: (i) hepatocytic vitronectin expression is associated to liver fibrogenesis in HCV-infected patients with iron overload; (ii) hepatic vitronectin expression was found to discriminate also the transition between mild to moderate fibrosis in HCV-infected patients without iron overload.	Iron	409-413	vitronectin	Homo sapiens	156-167
24601526-3	2014	The combined results from AF4 and XAS show that colloidal Fe is present as (i) free Fe-(hydr)oxide nanoparticles, (ii) Fe-(hydr)oxides associated with clay minerals, and (iii) Fe in clay minerals.	Iron	58-60	AF4/FMR2 family member 1	Homo sapiens	26-29
24714088-1	2014	Friedreich"s ataxia (FRDA) is a hereditary neurodegenerative disease characterized by a reduced synthesis of the mitochondrial iron chaperon protein frataxin as a result of a large GAA triplet-repeat expansion within the first intron of the frataxin gene.	Iron	127-131	frataxin	Mus musculus	21-25
24714088-1	2014	Friedreich"s ataxia (FRDA) is a hereditary neurodegenerative disease characterized by a reduced synthesis of the mitochondrial iron chaperon protein frataxin as a result of a large GAA triplet-repeat expansion within the first intron of the frataxin gene.	Iron	127-131	frataxin	Mus musculus	149-157
24303986-0	2014	Polymorphisms in calpastatin and mu-calpain genes are associated with beef iron content.	Iron	75-79	calpain 1	Bos taurus	33-43
24303986-1	2014	The objective of this study was to assess the association of markers in the calpastatin and mu-calpain loci with iron in beef cattle muscle.	Iron	113-117	calpain 1	Bos taurus	92-102
24303986-4	2014	Markers in the calpastatin (referred to as CAST) and mu-calpain (referred to as CAPN4751) genes were used to assess their association with iron levels.	Iron	139-143	calpain 1	Bos taurus	53-63
24433162-9	2014	Fe-S cluster-forming activity in isolated mitochondria was stimulated by the bypass Isu1, albeit at a lower rate.	Iron	0-4	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	84-88
24361124-14	2014	CONCLUSIONS: We identified a link between glucose and iron homeostasis, showing that Hepcidin is a gluconeogenic sensor in mice during starvation.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	85-93
24508277-3	2014	F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, regulates cellular and systemic iron homeostasis by facilitating iron regulatory protein 2 (IRP2) degradation.	Iron	113-117	iron responsive element binding protein 2	Mus musculus	146-171
24508277-3	2014	F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, regulates cellular and systemic iron homeostasis by facilitating iron regulatory protein 2 (IRP2) degradation.	Iron	113-117	iron responsive element binding protein 2	Mus musculus	173-177
24711810-7	2014	In addition, FROs appear to play important roles in subcellular compartmentalization of iron as FRO7 is known to contribute to delivery of iron to chloroplasts while mitochondrial family members FRO3 and FRO8 are hypothesized to influence mitochondrial metal ion homeostasis.	Iron	88-92	ferric reduction oxidase 7	Arabidopsis thaliana	96-100
24711810-7	2014	In addition, FROs appear to play important roles in subcellular compartmentalization of iron as FRO7 is known to contribute to delivery of iron to chloroplasts while mitochondrial family members FRO3 and FRO8 are hypothesized to influence mitochondrial metal ion homeostasis.	Iron	88-92	ferric reduction oxidase 8	Arabidopsis thaliana	204-208
24711810-7	2014	In addition, FROs appear to play important roles in subcellular compartmentalization of iron as FRO7 is known to contribute to delivery of iron to chloroplasts while mitochondrial family members FRO3 and FRO8 are hypothesized to influence mitochondrial metal ion homeostasis.	Iron	139-143	ferric reduction oxidase 7	Arabidopsis thaliana	96-100
24641804-9	2014	This iron-induced apoptosis was linked to enhanced caspase 8, reduced Bcl-2, Bcl-xL, phosphorylated Akt and GATA-4.	Iron	5-9	GATA binding protein 4	Homo sapiens	108-114
24641804-11	2014	In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged.	Iron	3-7	GATA binding protein 4	Homo sapiens	130-136
24275107-6	2014	Of the five materials examined, the results from P sorption and desorption studies clearly demonstrate that the iron based CFH is superior as a filter material compared to calcium based materials when tested against criteria for sorption affinity, capacity and stability.	Iron	112-116	complement factor H	Homo sapiens	123-126
24325979-9	2014	The log-ratio of intact FGF23 to C-terminal FGF23 was higher in XLH (0.00+-0.44) than controls (-0.28+-0.21, p&lt;0.01), and correlated positively to serum iron (controls r=0.276, p&lt;0.001; XLH r=0.428, p&lt;0.05), with a steeper slope in XLH (p&lt;0.01).	Iron	156-160	fibroblast growth factor 23	Homo sapiens	44-49
24325979-10	2014	CONCLUSION: Like controls, serum iron in XLH is inversely related to C-terminal FGF23 but not intact FGF23.	Iron	33-37	fibroblast growth factor 23	Homo sapiens	80-85
24325979-12	2014	The relationships of iron to FGF23 in XLH suggest that altered regulation of FGF23 cleaving may contribute to maintaining hypophosphatemia around an abnormal set-point.	Iron	21-25	fibroblast growth factor 23	Homo sapiens	29-34
24325979-12	2014	The relationships of iron to FGF23 in XLH suggest that altered regulation of FGF23 cleaving may contribute to maintaining hypophosphatemia around an abnormal set-point.	Iron	21-25	fibroblast growth factor 23	Homo sapiens	77-82
24374372-10	2014	However, deleterious effects caused by PINK1 mutations may be alleviated by iron-chelating agents and antioxidant agents with DA quinone-conjugating capacity.	Iron	76-80	PTEN induced kinase 1	Homo sapiens	39-44
24586826-10	2014	NGAL stimulated expression of HLA-G on CD4+ T cells in a dose- and iron-dependent manner.	Iron	67-71	lipocalin 2	Homo sapiens	0-4
24586826-10	2014	NGAL stimulated expression of HLA-G on CD4+ T cells in a dose- and iron-dependent manner.	Iron	67-71	major histocompatibility complex, class I, G	Homo sapiens	30-35
24357728-8	2014	Similarly to severe human anemia of inflammation, the B abortus model shows multifactorial pathogenesis of inflammatory anemia including iron restriction from increased hepcidin, transient suppression of erythropoiesis, and shortened erythrocyte lifespan.	Iron	137-141	hepcidin antimicrobial peptide	Mus musculus	169-177
24357728-9	2014	Ablation of hepcidin relieves iron restriction and improves the anemia.	Iron	30-34	hepcidin antimicrobial peptide	Mus musculus	12-20
24357729-2	2014	Induction of hepcidin, mediated by interleukin 6, leads to iron-restricted erythropoiesis and anemia.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	13-21
24034353-0	2014	Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload.	Iron	97-101	mitochondrial calcium uniporter	Rattus norvegicus	12-43
24034353-5	2014	We tested the hypothesis that iron overload can lead to cardiac mitochondrial dysfunction and that mitochondrial calcium uniporter (MCU) plays a major role for cardiac mitochondrial iron uptake under iron-overload condition.	Iron	182-186	mitochondrial calcium uniporter	Rattus norvegicus	99-130
24034353-5	2014	We tested the hypothesis that iron overload can lead to cardiac mitochondrial dysfunction and that mitochondrial calcium uniporter (MCU) plays a major role for cardiac mitochondrial iron uptake under iron-overload condition.	Iron	182-186	mitochondrial calcium uniporter	Rattus norvegicus	132-135
24034353-5	2014	We tested the hypothesis that iron overload can lead to cardiac mitochondrial dysfunction and that mitochondrial calcium uniporter (MCU) plays a major role for cardiac mitochondrial iron uptake under iron-overload condition.	Iron	182-186	mitochondrial calcium uniporter	Rattus norvegicus	99-130
24034353-5	2014	We tested the hypothesis that iron overload can lead to cardiac mitochondrial dysfunction and that mitochondrial calcium uniporter (MCU) plays a major role for cardiac mitochondrial iron uptake under iron-overload condition.	Iron	182-186	mitochondrial calcium uniporter	Rattus norvegicus	132-135
24034353-9	2014	RESULTS: We found that (i) iron overload caused cardiac mitochondrial dysfunction, indicated by increased ROS production, mitochondrial membrane depolarization and mitochondrial swelling; and (ii) only MCU blocker completely protected cardiac mitochondrial dysfunction caused by iron overload.	Iron	279-283	mitochondrial calcium uniporter	Rattus norvegicus	202-205
24034353-10	2014	CONCLUSIONS: These findings strongly suggest that MCU could be the major route for iron uptake into cardiac mitochondria.	Iron	83-87	mitochondrial calcium uniporter	Rattus norvegicus	50-53
24034353-11	2014	The inhibition of MCU could be the novel pharmacological intervention for preventing iron-overload cardiomyopathy.	Iron	85-89	mitochondrial calcium uniporter	Rattus norvegicus	18-21
24226520-2	2014	Although DMT1 plays a major role in intestinal iron absorption, the transporter is also highly expressed in the kidney, where its function remains unknown.	Iron	47-51	RoBo-1	Rattus norvegicus	9-13
24346829-2	2014	We aimed to investigate whether Fe activates Nrf2, in relation to its negative regulator Kelch-like ECH associated protein 1 (Keap1), with consequent antioxidant enzyme induction.	Iron	32-34	Kelch-like ECH-associated protein 1	Rattus norvegicus	89-124
24346829-2	2014	We aimed to investigate whether Fe activates Nrf2, in relation to its negative regulator Kelch-like ECH associated protein 1 (Keap1), with consequent antioxidant enzyme induction.	Iron	32-34	Kelch-like ECH-associated protein 1	Rattus norvegicus	126-131
24346829-7	2014	Normalization of Fe-induced oxidative stress status occurred concomitantly with that of Nrf2 and with the Nrf2-dependent HO-1 and NQO-1 expression, which are associated with delayed enhancement in cytosolic Keap1 levels.	Iron	17-19	heme oxygenase 1	Rattus norvegicus	121-125
23873717-8	2014	WT and ADHR pups receiving low iron had elevated intact serum FGF23; ADHR mice were affected to a greater degree (p &lt; 0.01).	Iron	31-35	fibroblast growth factor 23	Mus musculus	62-67
23873717-9	2014	Iron-deficient mice also showed increased Cyp24a1 and reduced Cyp27b1, and low serum 1,25-dihydroxyvitamin D (1,25D).	Iron	0-4	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	42-49
23873717-12	2014	These studies demonstrate that FGF23 is modulated by iron status in young WT and ADHR mice and that hypoxia independently controls FGF23 expression in situations of normal iron.	Iron	53-57	fibroblast growth factor 23	Mus musculus	31-36
23873717-13	2014	Therefore, disturbed iron and oxygen metabolism in neonatal life may have important effects on skeletal function and structure through FGF23 activity on phosphate regulation.	Iron	21-25	fibroblast growth factor 23	Mus musculus	135-140
25076541-1	2014	An organo-montmorillonite-supported nanoscale zero-valent iron material (M-NZVI) was synthesized to degrade decabromodiphenyl ether (BDE-209).	Iron	58-62	homeobox D13	Homo sapiens	133-136
24498153-17	2014	Lower Fe/S content and structural factors might be contributing to lower enzymatic efficiency of buffalo XOR in a minor way.	Iron	6-8	xanthine dehydrogenase	Bos taurus	105-108
24465846-8	2014	In iron-overloaded pancreas, the most upregulated transcripts were Reg1a, Reg3a, and Reg3b belonging to the regenerating islet-derived gene (Reg) family.	Iron	3-7	regenerating family member 1 alpha	Rattus norvegicus	67-72
24465846-8	2014	In iron-overloaded pancreas, the most upregulated transcripts were Reg1a, Reg3a, and Reg3b belonging to the regenerating islet-derived gene (Reg) family.	Iron	3-7	regenerating family member 3 beta	Rattus norvegicus	85-90
24465846-8	2014	In iron-overloaded pancreas, the most upregulated transcripts were Reg1a, Reg3a, and Reg3b belonging to the regenerating islet-derived gene (Reg) family.	Iron	3-7	regenerating family member 1 alpha	Rattus norvegicus	108-139
24465846-8	2014	In iron-overloaded pancreas, the most upregulated transcripts were Reg1a, Reg3a, and Reg3b belonging to the regenerating islet-derived gene (Reg) family.	Iron	3-7	regenerating family member 1 alpha	Rattus norvegicus	67-70
24465846-12	2014	Overall, these data raise the possibility that Reg expression may serve as a biomarker for iron-related pancreatic stress, and that iron deficiency may adversely affect the risk of developing diabetes through up-regulation of Alox15.	Iron	91-95	regenerating family member 1 alpha	Rattus norvegicus	47-50
24409331-4	2014	Hjv-/- mice developed systemic iron overload under all regimens.	Iron	31-35	hemojuvelin BMP co-receptor	Mus musculus	0-3
24409331-6	2014	Hepcidin mRNA expression responded to fluctuations in dietary iron intake, despite the absence of Hjv.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	0-8
24409331-7	2014	Nevertheless, iron-dependent upregulation of hepcidin was more than an order of magnitude lower compared to that seen in wild type controls.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	45-53
24409331-9	2014	These findings suggest that Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin.	Iron	120-124	hemojuvelin BMP co-receptor	Mus musculus	28-31
24409331-9	2014	These findings suggest that Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin.	Iron	120-124	hepcidin antimicrobial peptide	Mus musculus	138-146
24864106-4	2014	The biogenesis of [Fe-S] centers is crucial for heme synthesis because these co-factors determine the activity of IRP1 and that of ferrochelatase, an enzyme responsible for the insertion of an iron into protoporphyrin IX to produce heme.	Iron	193-197	ferrochelatase	Homo sapiens	131-145
25347084-7	2014	In animals fed with a control diet, the expression of three liver proteins involved in lipoprotein metabolism (ApoE), iron metabolism (Ftl), and regulation of nitric oxide generation (Ddah1) was up-regulated by the Pon1(-/-) genotype.	Iron	118-122	ferritin light polypeptide 1	Mus musculus	135-138
25335733-9	2014	Variants of NDRG1 mRNA were transcriptionally regulated after HepG2 and MCF-7 cells were treated by iron chelators, resulting in domination of NDRG1 mRNA Variant 1 (V1) in the HepG2 calls and domination of NDRG1 mRNA Variant 2 (V2) in the MCF-7 cells.	Iron	100-104	N-myc downstream regulated 1	Homo sapiens	12-17
25335733-9	2014	Variants of NDRG1 mRNA were transcriptionally regulated after HepG2 and MCF-7 cells were treated by iron chelators, resulting in domination of NDRG1 mRNA Variant 1 (V1) in the HepG2 calls and domination of NDRG1 mRNA Variant 2 (V2) in the MCF-7 cells.	Iron	100-104	N-myc downstream regulated 1	Homo sapiens	143-148
25335733-9	2014	Variants of NDRG1 mRNA were transcriptionally regulated after HepG2 and MCF-7 cells were treated by iron chelators, resulting in domination of NDRG1 mRNA Variant 1 (V1) in the HepG2 calls and domination of NDRG1 mRNA Variant 2 (V2) in the MCF-7 cells.	Iron	100-104	N-myc downstream regulated 1	Homo sapiens	143-148
24881668-6	2014	In addition, we characterized oxidation states of a heme iron in superoxide-treated hNgb with spectroscopic measurements.	Iron	57-61	neuroglobin	Homo sapiens	84-88
24881668-7	2014	Superoxide-treated hNgb in the ferric form was readily converted to the oxygenated ferrous form, and the result suggested that ferric hNgb could scavenge superoxide by change of an oxidation state in a heme iron.	Iron	207-211	neuroglobin	Homo sapiens	19-23
24881668-7	2014	Superoxide-treated hNgb in the ferric form was readily converted to the oxygenated ferrous form, and the result suggested that ferric hNgb could scavenge superoxide by change of an oxidation state in a heme iron.	Iron	207-211	neuroglobin	Homo sapiens	134-138
24881668-9	2014	As a consequence, we concluded that redox changes of the heme iron and the disulfide bond could regulate neuroprotective functions of hNgb, and it suggests that hNgb can afford protection against hypoxic and ischemic stress in the brain.	Iron	62-66	neuroglobin	Homo sapiens	134-138
24881668-9	2014	As a consequence, we concluded that redox changes of the heme iron and the disulfide bond could regulate neuroprotective functions of hNgb, and it suggests that hNgb can afford protection against hypoxic and ischemic stress in the brain.	Iron	62-66	neuroglobin	Homo sapiens	161-165
25429655-0	2014	Hormone responsive breast cancer and BRCA1 mutation: mechanism, regulation and iron-mediated effects.	Iron	79-83	BRCA1 DNA repair associated	Homo sapiens	37-42
25429655-6	2014	In fact estrogen and iron have been implicated to exert synergistic effects on cellular proliferation in BRCA1 linked hormone responsive breast cancer.	Iron	21-25	BRCA1 DNA repair associated	Homo sapiens	105-110
24141093-4	2014	Plasma-(59)Fe was cleared significantly faster in iron-deficient Fth(Delta/Delta)-mice than in iron-adequate Fth(lox/lox)-controls.	Iron	11-13	ferritin heavy polypeptide 1	Mus musculus	65-68
24141093-4	2014	Plasma-(59)Fe was cleared significantly faster in iron-deficient Fth(Delta/Delta)-mice than in iron-adequate Fth(lox/lox)-controls.	Iron	50-54	ferritin heavy polypeptide 1	Mus musculus	65-68
24141093-6	2014	(59)Fe uptake into the liver and spleen was significantly lower in iron-deficient Fth(Delta/Delta) than in Fth(lox/lox) mice 24 hours and 7 days after injection, respectively, and rapidly appeared in circulating erythrocytes instead.	Iron	4-6	ferritin heavy polypeptide 1	Mus musculus	82-85
24410688-4	2014	Results of batch ZVI reduction experiments showed that DNAN was completely reduced to 2,4-diaminoanisole and RDX was completely reduced to formaldehyde.	Iron	17-20	radixin	Homo sapiens	109-112
25762501-7	2014	We also show that ER stress combined with inflammation synergistically upregulated the expression of the iron carrier protein NGAL and the stress-inducible heme degrading enzyme heme oxygenase-1 (HO-1) leading to iron liberation.	Iron	213-217	lipocalin 2	Homo sapiens	126-130
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	25-27	iron-regulated transporter 1	Arabidopsis thaliana	68-72
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	25-27	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	74-81
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	iron-regulated transporter 1	Arabidopsis thaliana	68-72
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	74-81
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	iron-regulated transporter 1	Arabidopsis thaliana	68-72
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	74-81
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	iron-regulated transporter 1	Arabidopsis thaliana	68-72
24192296-7	2014	On the other hand, among Fe uptake-related genes, the expression of IRT1, bHLH038 and bHLH39 was lower in ga3ox1 ga3ox2 compared with the wild type (WT) under Fe-sufficient conditions, but the expression of all Fe uptake-related genes decreased under Fe-deficient conditions.	Iron	159-161	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	74-81
24192296-8	2014	Additionally, the PBZ treatment decreased IRT1 expression in the WT under Fe-deficient conditions, but not in the fit-2 mutant.	Iron	74-76	iron-regulated transporter 1	Arabidopsis thaliana	42-46
24358164-6	2013	We applied UV-VIS and EPR monitored redox-titrations to determine the redox potentials of wild type mAOX3 and mAOX3 variants containing the iron-sulfur centers of mAOX1.	Iron	140-144	aldehyde oxidase 1	Mus musculus	163-168
24316081-1	2013	Hepcidin, the iron-regulatory hormone and acute phase reactant, is proposed to contribute to the pathogenesis of atherosclerosis by promoting iron accumulation in plaque macrophages, leading to increased oxidative stress and inflammation in the plaque (the "iron hypothesis").	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	0-8
24316081-1	2013	Hepcidin, the iron-regulatory hormone and acute phase reactant, is proposed to contribute to the pathogenesis of atherosclerosis by promoting iron accumulation in plaque macrophages, leading to increased oxidative stress and inflammation in the plaque (the "iron hypothesis").	Iron	142-146	hepcidin antimicrobial peptide	Mus musculus	0-8
24055725-0	2013	PCB-77 disturbs iron homeostasis through regulating hepcidin gene expression.	Iron	16-20	hepcidin antimicrobial peptide	Mus musculus	52-60
24055725-4	2013	Iron metabolism is strictly governed by the hepcidin-ferroportin axis, and hepcidin is the key regulator that is secreted by hepatocytes.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	44-52
24055725-8	2013	Due to reduced hepcidin concentration, serum iron content was increased, with a significant reduction of splenic iron content.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	15-23
24055725-9	2013	Together, we deciphered the molecular mechanism responsible for PCB-conducted disturbance on iron homeostasis, i.e. through misregulating hepatic hepcidin expression.	Iron	93-97	hepcidin antimicrobial peptide	Mus musculus	146-154
24158698-0	2013	EGCG inhibit chemical reactivity of iron through forming an Ngal-EGCG-iron complex.	Iron	36-40	lipocalin 2	Homo sapiens	60-64
24158698-0	2013	EGCG inhibit chemical reactivity of iron through forming an Ngal-EGCG-iron complex.	Iron	70-74	lipocalin 2	Homo sapiens	60-64
24158698-6	2013	In this paper, Multivariate analysis of the LC-MS data of tea extracts and binding assays showed that the tea polyphenol EGCG can form stable complex with iron through the protein Ngal, a biomarker of acute kidney injury.	Iron	155-159	lipocalin 2	Homo sapiens	180-184
24158698-7	2013	UV-Vis and Luminescence spectrum methods showed that Ngal can inhibit the chemical reactivity of iron and EGCG through forming an Ngal-EGCG-iron complex.	Iron	97-101	lipocalin 2	Homo sapiens	53-57
24158698-7	2013	UV-Vis and Luminescence spectrum methods showed that Ngal can inhibit the chemical reactivity of iron and EGCG through forming an Ngal-EGCG-iron complex.	Iron	97-101	lipocalin 2	Homo sapiens	130-134
24158698-7	2013	UV-Vis and Luminescence spectrum methods showed that Ngal can inhibit the chemical reactivity of iron and EGCG through forming an Ngal-EGCG-iron complex.	Iron	140-144	lipocalin 2	Homo sapiens	53-57
24158698-7	2013	UV-Vis and Luminescence spectrum methods showed that Ngal can inhibit the chemical reactivity of iron and EGCG through forming an Ngal-EGCG-iron complex.	Iron	140-144	lipocalin 2	Homo sapiens	130-134
24121729-0	2013	Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice.	Iron	13-17	MON1 homolog A, secretory traffciking associated	Mus musculus	63-68
24121729-7	2013	Two highly significant QTL containing either the N374S Mon1a mutation or the Ferroportin locus were found to be major determinants in spleen and liver iron loading.	Iron	151-155	MON1 homolog A, secretory traffciking associated	Mus musculus	55-60
24121729-8	2013	Interestingly, when considering possible epistatic interactions, the effects of Mon1a on macrophage iron export are conditioned by the genotype at the Slc40a1 locus.	Iron	100-104	MON1 homolog A, secretory traffciking associated	Mus musculus	80-85
24121729-10	2013	Furthermore, the liver-iron lowering effect of the N374S Mon1a mutation is observed only in mice that display a nonsense mutation in the Ceruloplasmin (Cp) gene.	Iron	23-27	MON1 homolog A, secretory traffciking associated	Mus musculus	57-62
24222487-13	2013	In most organisms, hmp expression is controlled by the Fe-S cluster-containing repressor NsrR, but this transcriptional regulator is absent in the human pathogen Staphylococcus aureus.	Iron	55-59	inner membrane mitochondrial protein	Homo sapiens	19-22
24036496-3	2013	METHODS AND RESULTS: Here we report that iron depots accumulate in human atherosclerotic plaque areas enriched in CD68 and mannose receptor (MR)-positive (CD68(+)MR(+)) alternative M2 macrophages.	Iron	41-45	CD68 molecule	Homo sapiens	114-118
24036496-3	2013	METHODS AND RESULTS: Here we report that iron depots accumulate in human atherosclerotic plaque areas enriched in CD68 and mannose receptor (MR)-positive (CD68(+)MR(+)) alternative M2 macrophages.	Iron	41-45	CD68 molecule	Homo sapiens	155-159
24105732-1	2013	A one-pot method has been developed for the oxidative cleavage of internal alkenes into aldehydes by using 0.5 mol% of the nonheme iron complex [Fe(OTf)2(mix-bpbp)] (bpbp=N,N"-bis(2-picolyl)-2,2"-bipyrrolidine) as catalyst and 1.5 equivalents of hydrogen peroxide and 1 equivalent of sodium periodate as oxidants.	Iron	131-135	POU class 2 homeobox 2	Homo sapiens	148-153
23945155-0	2013	A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	19-27
24114785-0	2013	Strong premelting effect in the elastic properties of hcp-Fe under inner-core conditions.	Iron	58-60	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	54-57
24114785-3	2013	Using ab initio molecular dynamics simulations, we obtained the elastic properties of hexagonal close-packed iron (hcp-Fe) at 360 gigapascals up to its melting temperature Tm.	Iron	109-113	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	115-118
24114785-3	2013	Using ab initio molecular dynamics simulations, we obtained the elastic properties of hexagonal close-packed iron (hcp-Fe) at 360 gigapascals up to its melting temperature Tm.	Iron	119-121	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	115-118
23990467-0	2013	Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation.	Iron	83-87	STEAP4 metalloreductase	Homo sapiens	0-6
23990467-2	2013	Iron uptake by osteoclast precursors via the transferrin cycle increases mitochondrial biogenesis, reactive oxygen species production, and activation of cAMP response element-binding protein, a critical transcription factor downstream of receptor activator of NF-kappaB-ligand-induced calcium signaling.	Iron	0-4	cAMP responsive element binding protein 1	Homo sapiens	153-190
23990467-5	2013	In this report, we provide evidence that Steap4, a member of the six-transmembrane epithelial antigen of prostate (Steap) family proteins, is an endosomal ferrireductase with a critical role in cellular iron utilization in osteoclasts.	Iron	203-207	STEAP4 metalloreductase	Homo sapiens	41-47
23990467-7	2013	Knocking down Steap4 expression in vitro by lentivirus-mediated short hairpin RNAs inhibits osteoclast formation and decreases cellular ferrous iron, reactive oxygen species, and the activation of cAMP response element-binding protein.	Iron	136-148	STEAP4 metalloreductase	Homo sapiens	14-20
23990467-8	2013	These results demonstrate that Steap4 is a critical enzyme for cellular iron uptake and utilization in osteoclasts and, thus, indispensable for osteoclast development and function.	Iron	72-76	STEAP4 metalloreductase	Homo sapiens	31-37
24146952-7	2013	Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN).	Iron	12-16	aconitase 1	Mus musculus	111-123
24146952-7	2013	Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN).	Iron	87-91	aconitase 1	Mus musculus	111-123
24146952-7	2013	Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN).	Iron	87-91	aconitase 1	Mus musculus	111-123
24146952-7	2013	Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN).	Iron	87-91	aconitase 1	Mus musculus	111-123
23834247-4	2013	In the present study we, for the first time based on both in vitro and in vivo studies, show that yeast Mia40 can exist as an Fe-S (iron-sulfur) protein as well.	Iron	126-130	Mia40p	Saccharomyces cerevisiae S288C	104-109
23834247-4	2013	In the present study we, for the first time based on both in vitro and in vivo studies, show that yeast Mia40 can exist as an Fe-S (iron-sulfur) protein as well.	Iron	132-136	Mia40p	Saccharomyces cerevisiae S288C	104-109
23834247-6	2013	The biological relevance of the cofactor binding was confirmed in vivo by cysteine redox state and iron uptake analyses, which showed that a significant amount of cellular Mia40 binds iron in vivo.	Iron	99-103	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	172-177
23834247-6	2013	The biological relevance of the cofactor binding was confirmed in vivo by cysteine redox state and iron uptake analyses, which showed that a significant amount of cellular Mia40 binds iron in vivo.	Iron	184-188	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	172-177
23834247-7	2013	Furthermore, our oxygen consumption results suggested that the Fe-S-containing Mia40 is not an electron donor for Erv1.	Iron	63-67	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	79-84
23615502-0	2013	Hepcidin regulates intrarenal iron handling at the distal nephron.	Iron	30-34	hepcidin antimicrobial peptide	Mus musculus	0-8
23615502-1	2013	Hepcidin, the key regulatory hormone of iron homeostasis, and iron carriers such as transferrin receptor1 (TFR1), divalent metal transporter1 (DMT1), and ferroportin (FPN) are expressed in kidney.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	0-8
23615502-2	2013	Whether hepcidin plays an intrinsic role in the regulation of renal iron transport is unknown.	Iron	68-72	hepcidin antimicrobial peptide	Mus musculus	8-16
23615502-4	2013	We found a marked medullary iron deposition in the kidneys of Hepc(-/-) mice, and iron leak in the urine.	Iron	28-32	hepcidin antimicrobial peptide	Mus musculus	62-66
23615502-12	2013	Hepcidin may control the expression of iron transporters to prevent renal iron overload.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	0-8
24032747-2	2013	A number of phenotypes including low levels of Fe-S cluster incorporation are associated with the deletion of the gene encoding a chloroplast-specific Nfu-type protein, Nfu2 from Arabidopsis thaliana (AtNfu2).	Iron	47-51	NIFU-like protein 2	Arabidopsis thaliana	169-173
24032747-2	2013	A number of phenotypes including low levels of Fe-S cluster incorporation are associated with the deletion of the gene encoding a chloroplast-specific Nfu-type protein, Nfu2 from Arabidopsis thaliana (AtNfu2).	Iron	47-51	NIFU-like protein 2	Arabidopsis thaliana	201-207
24032747-10	2013	This cluster transfer is likely to be physiologically relevant and is particularly significant for plant metabolism as APR1 catalyzes the second step in reductive sulfur assimilation, which ultimately results in the biosynthesis of cysteine, methionine, glutathione, and Fe-S clusters.	Iron	271-275	APS reductase 1	Arabidopsis thaliana	119-123
23895017-6	2013	A plausible mechanism of toluene degradation using [FeCl2(bpmcn)] (1) and [Fe(OTf)2(Pytacn)] (3) as catalysts was proposed, which involves the coexistence of a metal-based path, analogous to that operating in organic media where substrate oxidation is executed by an iron(V)-oxo-hydroxo species, in parallel to a Fenton-type process where hydroxyl radicals are formed.	Iron	267-271	POU class 2 homeobox 2	Homo sapiens	78-83
23416443-5	2013	Human neuroglobin (NGB), which appears to protect neurons from hypoxia in vitro and in vivo, undergoes hypoxia-dependent phosphorylation (i.e., covalent modulation) affecting the coordination equilibrium of the heme-Fe atom and, in turn, the heme-protein reactivity.	Iron	216-218	neuroglobin	Homo sapiens	6-17
23416443-5	2013	Human neuroglobin (NGB), which appears to protect neurons from hypoxia in vitro and in vivo, undergoes hypoxia-dependent phosphorylation (i.e., covalent modulation) affecting the coordination equilibrium of the heme-Fe atom and, in turn, the heme-protein reactivity.	Iron	216-218	neuroglobin	Homo sapiens	19-22
23416443-9	2013	Lastly, the reactivity of NGB and CYGB is modulated by the redox state of the intramolecular CysCD7/CysD5 and CysB2/CysE9 residue pairs, respectively, affecting the heme-Fe atom coordination state.	Iron	170-172	neuroglobin	Homo sapiens	26-29
23999366-6	2013	Moreover, medication such as infusion of select iron-containing compounds increases serum FGF23 concentrations, with patients developing hypophosphatemia.	Iron	48-52	fibroblast growth factor 23	Homo sapiens	90-95
23999366-7	2013	Thus, a relationship between metal ion (Cd and Fe) and FGF23 metabolic pathway has been proposed.	Iron	47-49	fibroblast growth factor 23	Homo sapiens	55-60
23179203-8	2013	A negative correlation (P &lt; 0.05) between free iron concentrations and gene expression levels of both STEAP4 and NGAL was found, while circulating ferritin concentrations were positively correlated (P &lt; 0.05) with NGAL mRNA after body fat (BF) adjustment.	Iron	50-54	STEAP4 metalloreductase	Homo sapiens	105-111
23179203-8	2013	A negative correlation (P &lt; 0.05) between free iron concentrations and gene expression levels of both STEAP4 and NGAL was found, while circulating ferritin concentrations were positively correlated (P &lt; 0.05) with NGAL mRNA after body fat (BF) adjustment.	Iron	50-54	lipocalin 2	Homo sapiens	116-120
23179203-10	2013	CONCLUSION: These findings represent the first observation that STEAP4 and NGAL mRNA and protein levels in human VAT are related to iron status.	Iron	132-136	STEAP4 metalloreductase	Homo sapiens	64-70
23179203-10	2013	CONCLUSION: These findings represent the first observation that STEAP4 and NGAL mRNA and protein levels in human VAT are related to iron status.	Iron	132-136	lipocalin 2	Homo sapiens	75-79
23531432-3	2013	Furthermore, iron can compromise the solubility of alpha-synuclein through direct interaction and can induce neurotoxicity in vitro.	Iron	13-17	synuclein alpha	Rattus norvegicus	51-66
23531432-10	2013	Taken together, our data show that in vivo iron chelation can modulate alpha-synuclein-induced pathology in the central nervous system.	Iron	43-47	synuclein alpha	Rattus norvegicus	71-86
23817614-3	2013	Accordingly, the genome of this strain has three tonB genes encoding proteins for energy transduction functions needed for the active transport of nutrients, including iron, through the outer membrane.	Iron	168-172	tonB dependent receptor	Acinetobacter baumannii	49-53
23817614-6	2013	The abilities of components of these TonB systems to complement the growth defect of Escherichia coli W3110 mutants KP1344 (tonB) and RA1051 (exbBD) under iron-chelated conditions further support the roles of these TonB systems in iron acquisition.	Iron	155-159	tonB dependent receptor	Acinetobacter baumannii	37-41
23817614-6	2013	The abilities of components of these TonB systems to complement the growth defect of Escherichia coli W3110 mutants KP1344 (tonB) and RA1051 (exbBD) under iron-chelated conditions further support the roles of these TonB systems in iron acquisition.	Iron	231-235	tonB dependent receptor	Acinetobacter baumannii	37-41
23817614-6	2013	The abilities of components of these TonB systems to complement the growth defect of Escherichia coli W3110 mutants KP1344 (tonB) and RA1051 (exbBD) under iron-chelated conditions further support the roles of these TonB systems in iron acquisition.	Iron	231-235	tonB dependent receptor	Acinetobacter baumannii	215-219
23817614-10	2013	Taken together, these results indicate that A. baumannii ATCC 19606(T) produces three independent TonB proteins, which appear to provide the energy-transducing functions needed for iron acquisition and cellular processes that play a role in the virulence of this pathogen.	Iron	181-185	tonB dependent receptor	Acinetobacter baumannii	98-102
23643521-10	2013	However, both the HF and excess iron loading changed the hepatic expression of hepcidin and ferroportin.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	79-87
23846698-0	2013	Hepcidin bound to alpha2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels.	Iron	116-120	hepcidin antimicrobial peptide	Mus musculus	0-8
23846698-1	2013	Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1).	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	0-8
23846698-10	2013	However, serum iron levels were reduced to a significantly greater extent in mice treated with alpha2M hepcidin or alpha2M-MA hepcidin relative to unbound hepcidin.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	103-111
23846698-10	2013	However, serum iron levels were reduced to a significantly greater extent in mice treated with alpha2M hepcidin or alpha2M-MA hepcidin relative to unbound hepcidin.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	126-134
23846698-10	2013	However, serum iron levels were reduced to a significantly greater extent in mice treated with alpha2M hepcidin or alpha2M-MA hepcidin relative to unbound hepcidin.	Iron	15-19	hepcidin antimicrobial peptide	Mus musculus	126-134
23777768-0	2013	IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation.	Iron	43-47	aconitase 1	Mus musculus	0-4
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	19-23	aconitase 1	Mus musculus	242-246
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	19-23	iron responsive element binding protein 2	Mus musculus	251-255
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	120-124	aconitase 1	Mus musculus	242-246
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	120-124	iron responsive element binding protein 2	Mus musculus	251-255
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	120-124	aconitase 1	Mus musculus	242-246
23777768-3	2013	The presence of an iron-responsive element (IRE) within the 5" untranslated region of HIF2alpha mRNA suggests a further iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively).	Iron	120-124	iron responsive element binding protein 2	Mus musculus	251-255
23777768-4	2013	We show here that the disruption of mouse IRP1, but not IRP2, leads to profound HIF2alpha-dependent abnormalities in erythropoiesis and systemic iron metabolism.	Iron	145-149	aconitase 1	Mus musculus	42-46
23597830-2	2013	The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form.	Iron	4-8	RoBo-1	Rattus norvegicus	28-56
23597830-2	2013	The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form.	Iron	4-8	RoBo-1	Rattus norvegicus	58-62
23597830-2	2013	The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form.	Iron	4-8	RoBo-1	Rattus norvegicus	244-248
23891004-6	2013	Surprisingly, a second layer of iron regulation involves the stabilization of IRP2 by CIA2A binding or upon depletion of CIA2B or MMS19, even though IRP2 lacks an Fe/S cluster.	Iron	32-36	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	130-135
23553521-1	2013	Hepcidin is a peptide hormone that plays an important role in iron metabolism.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	0-8
23553521-5	2013	However, synthetic human hepcidin-25 was more efficient than recombinant mouse hepcidin-1 in reducing iron concentration in blood circulation (p &lt; 0.01).	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	25-33
23553521-5	2013	However, synthetic human hepcidin-25 was more efficient than recombinant mouse hepcidin-1 in reducing iron concentration in blood circulation (p &lt; 0.01).	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	79-87
23615401-8	2013	HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells.	Iron	49-53	matrix metallopeptidase 9	Homo sapiens	96-101
23922777-1	2013	Control of systemic iron homeostasis is interconnected with the inflammatory response through the key iron regulator, the antimicrobial peptide hepcidin.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	144-152
23922777-1	2013	Control of systemic iron homeostasis is interconnected with the inflammatory response through the key iron regulator, the antimicrobial peptide hepcidin.	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	144-152
23922777-2	2013	We have previously shown that mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficient-high hepcidin Tmprss6 KO mice.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	73-81
23922777-2	2013	We have previously shown that mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficient-high hepcidin Tmprss6 KO mice.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	154-162
23922777-8	2013	Opposite to Tmprss6 KO mice, Hfe(-/-) mice are characterized by iron overload with inappropriately low hepcidin levels.	Iron	64-68	homeostatic iron regulator	Mus musculus	29-32
23874600-7	2013	Inhibition of beta2-M or HFE sensitized prostate cancer cells to radiation by increasing iron and reactive oxygen species and decreasing DNA repair and stress response proteins.	Iron	89-93	homeostatic iron regulator	Mus musculus	25-28
23361852-4	2013	Divalent metal transporter 1(DMT1) has been widely described in literature as a key player in iron metabolism, but never before in the PNS context.	Iron	94-98	RoBo-1	Rattus norvegicus	0-28
23361852-4	2013	Divalent metal transporter 1(DMT1) has been widely described in literature as a key player in iron metabolism, but never before in the PNS context.	Iron	94-98	RoBo-1	Rattus norvegicus	29-33
23361852-8	2013	These data allow us to suggest the participation of DMT1 as part of a Tf independent iron uptake mechanism in SC and lead us to postulate a crucial role for iron in SC maturation and, as a consequence, in PNS myelination.	Iron	85-89	RoBo-1	Rattus norvegicus	52-56
23361852-8	2013	These data allow us to suggest the participation of DMT1 as part of a Tf independent iron uptake mechanism in SC and lead us to postulate a crucial role for iron in SC maturation and, as a consequence, in PNS myelination.	Iron	157-161	RoBo-1	Rattus norvegicus	52-56
23702591-0	2013	Bacterial community of iron tubercles from a drinking water distribution system and its occurrence in stagnant tap water.	Iron	23-27	nuclear RNA export factor 1	Homo sapiens	111-114
23702591-8	2013	Inorganic contaminants at low levels, including Al, Mn, Zn, Pb, Cr, Cu, and Ni, were detected in tubercles and were concentrated in particulates from tap water following the release of iron during stagnation.	Iron	185-189	nuclear RNA export factor 1	Homo sapiens	150-153
23349308-0	2013	ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders.	Iron	81-85	RoBo-1	Rattus norvegicus	10-14
23349308-0	2013	ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders.	Iron	135-139	RoBo-1	Rattus norvegicus	10-14
23628648-3	2013	Evaluation of these intensity oscillations using the phase accumulation model provides information on the unoccupied spin polarized band structure in the Fe film above the vacuum level.	Iron	154-156	spindlin 1	Homo sapiens	117-121
23628648-0	2013	Spin polarized low energy electron microscopy of quantum well resonances in Fe films on the Cu-covered W(110) surface.	Iron	76-78	spindlin 1	Homo sapiens	0-4
23628648-1	2013	Spin polarized low energy electron microscopy has been used to investigate the quantum size effect (QSE) in electron reflectivity from Fe films grown on a pseudomorphic Cu layer on a W(110) surface.	Iron	135-137	spindlin 1	Homo sapiens	0-4
23628648-4	2013	We also find evidence that the presence of the non-magnetic Cu layer shifts spin polarized quantum well resonances in the Fe layer uniformly downward in energy by 1.1eV compared to Fe/W(110) films without an interface Cu layer, suggesting that the Cu layer gives a small degree of control over the quantum well resonances.	Iron	122-124	spindlin 1	Homo sapiens	76-80
24024382-7	2013	CONCLUSION: The nutritional status of the iron may be affected by copper deficiency through influencing the absorption, the results indicate that copper deficiency influences iron homeostasis in cells through affecting the expression of IRP2 and the activity of IRP-RNA combination which change the expressions of ferritin and transferrin mRNA.	Iron	42-46	iron responsive element binding protein 2	Rattus norvegicus	237-241
24024382-7	2013	CONCLUSION: The nutritional status of the iron may be affected by copper deficiency through influencing the absorption, the results indicate that copper deficiency influences iron homeostasis in cells through affecting the expression of IRP2 and the activity of IRP-RNA combination which change the expressions of ferritin and transferrin mRNA.	Iron	175-179	iron responsive element binding protein 2	Rattus norvegicus	237-241
23826084-1	2013	We report the discovery of a novel dual inhibitor targeting fungal sterol 14alpha-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core.	Iron	208-212	lysyl oxidase	Homo sapiens	139-142
23668325-5	2013	Reincubation of this intermediate with 8R-LOX successfully demonstrated its conversion to the enone products, and this reaction was greatly accelerated by coincubation with NDGA, a reductant of the LOX iron.	Iron	202-206	lysyl oxidase	Homo sapiens	42-45
23668325-5	2013	Reincubation of this intermediate with 8R-LOX successfully demonstrated its conversion to the enone products, and this reaction was greatly accelerated by coincubation with NDGA, a reductant of the LOX iron.	Iron	202-206	lysyl oxidase	Homo sapiens	198-201
23599042-3	2013	The Belgrade rat carries a mutation in the iron transporter divalent metal transporter 1 (DMT1) resulting in iron-loading anemia.	Iron	43-47	RoBo-1	Rattus norvegicus	60-88
23599042-3	2013	The Belgrade rat carries a mutation in the iron transporter divalent metal transporter 1 (DMT1) resulting in iron-loading anemia.	Iron	43-47	RoBo-1	Rattus norvegicus	90-94
23599042-7	2013	These findings suggest that loss of DMT1 protects against oxidative damage to the pancreas and helps to maintain insulin sensitivity despite iron overload.	Iron	141-145	RoBo-1	Rattus norvegicus	36-40
23578384-1	2013	Increased iron stores associated with elevated levels of the iron hormone hepcidin are a frequent feature of the metabolic syndrome.	Iron	10-14	hepcidin antimicrobial peptide	Mus musculus	74-82
23578384-1	2013	Increased iron stores associated with elevated levels of the iron hormone hepcidin are a frequent feature of the metabolic syndrome.	Iron	61-65	hepcidin antimicrobial peptide	Mus musculus	74-82
23578384-3	2013	Iron supplementation increased hepatic iron and serum hepcidin fivefold and led to a 40% increase in fasting glucose due to insulin resistance, as confirmed by the insulin tolerance test, and to threefold higher levels of triglycerides.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	54-62
23578384-8	2013	In conclusion, we characterized a model of dysmetabolic iron overload syndrome in which an iron-enriched diet induces insulin resistance and hypertriglyceridemia and affects visceral adipose tissue metabolism by a mechanism involving hepcidin up-regulation.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	234-242
23547009-5	2013	Our results revealed that three novel reference genes (SAND, YLS8 and TIP41-like) were identified and validated as suitable reference genes for qRT-PCR normalization in both iron deprivation (the addition of Ferrozine to the medium) and starvation (withdrawal of iron from the medium) conditions.	Iron	174-178	mRNA splicing factor, thioredoxin-like U5 snRNP	Arabidopsis thaliana	61-65
23547009-5	2013	Our results revealed that three novel reference genes (SAND, YLS8 and TIP41-like) were identified and validated as suitable reference genes for qRT-PCR normalization in both iron deprivation (the addition of Ferrozine to the medium) and starvation (withdrawal of iron from the medium) conditions.	Iron	263-267	mRNA splicing factor, thioredoxin-like U5 snRNP	Arabidopsis thaliana	61-65
23390091-9	2013	Analysis of primary hepatocytes from mice lacking furin, PC5, PACE4, or PC7 revealed that hepcidin, which limits iron availability in the circulation, is specifically generated by furin and not by PC7.	Iron	113-117	hepcidin antimicrobial peptide	Mus musculus	90-98
23631927-3	2013	Iron deficient pregnant dams and their pups displayed elevated corticosterone which, in turn, differentially affected glucocorticoid receptor (GR) expression in the CA1 and the dentate gyrus.	Iron	0-4	carbonic anhydrase 1	Homo sapiens	165-168
23624806-0	2013	Iron and zinc complexation in wild-type and ferritin-expressing wheat grain: implications for mineral transport into developing grain.	Iron	0-4	Fer2	Triticum aestivum	44-52
23660665-5	2013	Two genes involved in iron-heme homeostasis, CD163 and heme oxygenase (HO-1), were analysed in 34 plaques.	Iron	22-26	CD163 molecule	Homo sapiens	45-50
23722909-3	2013	The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple proteins, including hemojuvelin, bone morphogenetic protein 6 (BMP6), hereditary hemochromatosis protein, transferrin receptor 2, matriptase-2, neogenin, BMP receptors, and transferrin.	Iron	41-45	neogenin 1	Homo sapiens	254-262
23598994-3	2013	One explanation for this is that some accumulated Fe misincorporates into apo-Sod2p.	Iron	50-52	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	78-83
23615440-1	2013	The mitochondrial Hsp70 chaperone Ssq1 plays a dedicated role in the maturation of iron-sulfur (Fe/S) proteins, an essential process of mitochondria.	Iron	96-98	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
23335088-6	2013	More importantly, GDF15 induction was positively correlated to upregulation of ferroportin, the only cellular iron exporter, and to upregulation of ferritin heavy chain.	Iron	110-114	growth differentiation factor 15	Homo sapiens	18-23
23335088-7	2013	CONCLUSIONS: Our study suggests that GDF15 induction helps suppress further activation of macrophages in stressful physiologic states as HLH, and is intimately implicated in the development of hyperferritinemia by modulating the hepcidin-ferroportin axis, resulting in enhanced ferroportin-mediated iron efflux.	Iron	299-303	growth differentiation factor 15	Homo sapiens	37-42
23111618-1	2013	H-ferritin (HF) is a core subunit of the iron storage protein ferritin, and plays a central role in the regulation of cellular iron homeostasis.	Iron	41-45	ferritin heavy polypeptide 1	Mus musculus	0-10
23111618-1	2013	H-ferritin (HF) is a core subunit of the iron storage protein ferritin, and plays a central role in the regulation of cellular iron homeostasis.	Iron	41-45	ferritin heavy polypeptide 1	Mus musculus	12-14
24385778-1	2013	OBJECTIVE: The aim of this study was to evaluate the clinical significance of reticulocyte hemoglobin content (CHr) in the diagnosis of iron deficiency anemia (IDA) and to compare it with other conventional iron parameters.	Iron	136-140	chromate resistance; sulfate transport	Homo sapiens	111-114
24385778-4	2013	CHr showed a significant positive correlation with hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, serum iron, and transferrin saturation and a significant negative correlation with transferrin and total iron-binding capacity.	Iron	166-170	chromate resistance; sulfate transport	Homo sapiens	0-3
24385778-4	2013	CHr showed a significant positive correlation with hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, serum iron, and transferrin saturation and a significant negative correlation with transferrin and total iron-binding capacity.	Iron	265-269	chromate resistance; sulfate transport	Homo sapiens	0-3
23737963-3	2013	To better assess the iron status we developed a novel mass spectrometry assay to quantify pig plasma levels of the iron-regulatory peptide hormone hepcidin-25.	Iron	21-25	hepcidin antimicrobial peptide	Sus scrofa	147-155
23737963-5	2013	The routinely used protocol with high amount of iron resulted in the recovery of piglets from iron deficiency but also in strongly elevated plasma hepcidin-25 levels.	Iron	48-52	hepcidin antimicrobial peptide	Sus scrofa	147-155
23737963-7	2013	These data show that plasma hepcidin-25 levels can guide optimal dosing of iron treatment and pave the way for mixed supplementation of piglets starting with intramuscular injection of iron dextran followed by dietary supplementation, which could be efficient under condition of very low plasma hepcidin-25 level.	Iron	75-79	hepcidin antimicrobial peptide	Sus scrofa	28-36
23717386-6	2013	Importantly, the drug pioglitazone abrogates NAF-1"s ability to transfer the cluster to acceptor proteins and iron to mitochondria.	Iron	110-114	CDGSH iron sulfur domain 2	Homo sapiens	45-50
23705020-1	2013	Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function.	Iron	31-35	homeostatic iron regulator	Mus musculus	137-140
23705020-1	2013	Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function.	Iron	90-94	homeostatic iron regulator	Mus musculus	137-140
23705020-3	2013	Loss of HFE function is known to alter the intestinal expression of DMT1 (divalent metal transporter-1) and Fpn (ferroportin), transporters that have been implicated in absorption of both iron and manganese.	Iron	188-192	homeostatic iron regulator	Mus musculus	8-11
23457300-3	2013	A previous microarray study in a vma mutant demonstrated up-regulation of multiple iron uptake genes under control of Aft1p (the iron regulon) and only one antioxidant gene, the peroxiredoxin TSA2 (Milgrom, E., Diab, H., Middleton, F., and Kane, P. M. (2007) Loss of vacuolar proton-translocating ATPase activity in yeast results in chronic oxidative stress.	Iron	83-87	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	118-123
23592921-7	2013	Mutation profiling of positional-candidate genes detected a heterozygous, noncoding G-to-T transversion (c.-168G&gt;T) located in the iron response element (IRE) of the gene coding for ferritin light chain (FTL) that cosegregated with cataract in the family.	Iron	134-138	ferritin light chain	Homo sapiens	185-205
23592921-7	2013	Mutation profiling of positional-candidate genes detected a heterozygous, noncoding G-to-T transversion (c.-168G&gt;T) located in the iron response element (IRE) of the gene coding for ferritin light chain (FTL) that cosegregated with cataract in the family.	Iron	134-138	ferritin light chain	Homo sapiens	207-210
23404507-7	2013	Whereas JAK3 and Fes marginally activate PLD2 in non-transformed cells, these kinases greatly enhance (&gt;200%) PLD activity following protein-protein interaction through the SH2 domain and the Tyr-415 residue of PLD2.	Iron	17-20	phospholipase D2	Homo sapiens	41-45
23404507-8	2013	We also found that phosphatidic acid enhances Fes activity in MDA-MB-231 cells providing a positive activation loop between Fes and PLD2.	Iron	46-49	phospholipase D2	Homo sapiens	132-136
23582421-6	2013	Sequencing of Tfr2 in the iron-overloaded rat revealed a novel Ala679Gly polymorphism in a highly conserved residue.	Iron	26-30	transferrin receptor 2	Rattus norvegicus	14-18
23582421-10	2013	However, we currently cannot exclude the possibility that a polymorphism or mutation in the noncoding region of Tfr2 contributes to the iron-overload phenotype.	Iron	136-140	transferrin receptor 2	Rattus norvegicus	112-116
23215739-2	2013	HO-1 catalyzes the conversion of heme protein to biliverdin, free iron, and carbon monoxide.	Iron	66-70	heme oxygenase 1	Rattus norvegicus	0-4
27877555-4	2013	The driving force for the fcc to hcp transition, defined as a dimensionless value -dGm/(RT), was determined in the presence of Fe-rich and Mn-rich composition sets in each phase.	Iron	127-129	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	33-36
22462691-0	2013	The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.	Iron	4-8	N-myc downstream regulated 1	Homo sapiens	41-46
22462691-0	2013	The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.	Iron	4-8	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	55-61
22462691-2	2013	Moreover, NDRG1 is an iron-regulated gene that is markedly upregulated by cellular iron-depletion using novel antitumor agents such as the chelator, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), in pancreatic cancer cells.	Iron	22-26	N-myc downstream regulated 1	Homo sapiens	10-15
22462691-2	2013	Moreover, NDRG1 is an iron-regulated gene that is markedly upregulated by cellular iron-depletion using novel antitumor agents such as the chelator, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), in pancreatic cancer cells.	Iron	83-87	N-myc downstream regulated 1	Homo sapiens	10-15
23306176-1	2013	We have studied the atomic structure and energetic stability of helium (He) and He-vacancy clusters in an iron (Fe) Sigma5(310)/[001] grain boundary (GB) using a first-principles method.	Iron	106-110	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	116-122
23306176-1	2013	We have studied the atomic structure and energetic stability of helium (He) and He-vacancy clusters in an iron (Fe) Sigma5(310)/[001] grain boundary (GB) using a first-principles method.	Iron	112-114	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	116-122
22878006-13	2013	CONCLUSIONS: Patients with SCD exhibited significant quantifiable changes in the craniofacial bone marrow because of failure of red-to-yellow marrow conversion and iron deposition that can be identified by qMRI relaxometry and volumetry.	Iron	164-168	stearoyl-CoA desaturase	Homo sapiens	27-30
23403335-13	2013	The monoclonal antibody Mac387 stains, along with Perls stains, showed preferential localization of newly recruited macrophages at the site of chronic iron deposition.	Iron	151-155	S100 calcium binding protein A9	Homo sapiens	24-30
23585716-5	2013	These series of drugs have the ability of regulating and processing amyloid precursor protein (APP) since APP and alpha-synuclein are metaloproteins (iron-regulated proteins), with an iron responsive element 5"UTR mRNA similar to transferring and ferritin.	Iron	150-154	amyloid beta precursor protein	Rattus norvegicus	68-93
23193175-0	2013	The rotavirus nonstructural protein NSP5 coordinates a [2Fe-2S] iron-sulfur cluster that modulates interaction to RNA.	Iron	64-68	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	36-40
23193175-3	2013	Here we report that NSP5 is a unique viral metalloprotein that coordinates a [2Fe-2S] iron-sulfur cluster as demonstrated by the metal and labile sulfide contents, UV-visible light absorption, and electron paramagnetic resonance.	Iron	86-90	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	20-24
23193175-5	2013	When coexpressed with NSP2, an NSP5 mutant devoid of the iron-sulfur cluster still forms viroplasm-like structures.	Iron	57-61	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	31-35
23193175-7	2013	Finally, we show using microscale thermophoresis that the iron-sulfur cluster modulates the affinity of NSP5 for single-stranded RNA.	Iron	58-62	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	104-108
23421845-2	2013	The disease is caused by mutations in the Iron-Responsive Element (IRE) located in the 5" untranslated region of L-Ferritin (FTL) mRNA, which post-transcriptionally regulates ferritin expression.	Iron	42-46	ferritin light chain	Homo sapiens	125-128
25166385-5	2013	The proposed surface model with identified Fe-containing atomic ensembles could explain the Al(13)Fe(4) catalytic properties recently reported in line with the site-isolation concept [M. Armbruster et al., Nat.	Iron	43-45	bromodomain containing 2	Homo sapiens	206-209
23264625-1	2013	alpha-Hemoglobin stabilizing protein (AHSP) is a molecular chaperone that binds monomeric alpha-subunits of human hemoglobin A (HbA) and modulates heme iron oxidation and subunit folding states.	Iron	152-156	sodium voltage-gated channel alpha subunit 2	Homo sapiens	128-131
22241739-0	2013	Regulation of iron metabolism in Hamp               (-/-) mice in response to iron-deficient diet.	Iron	14-18	hepcidin antimicrobial peptide	Mus musculus	33-37
22241739-0	2013	Regulation of iron metabolism in Hamp               (-/-) mice in response to iron-deficient diet.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	33-37
22241739-1	2013	BACKGROUND: Hepcidin, the liver-secreted iron regulatory peptide, maintains systemic iron homeostasis in response to several stimuli including dietary iron levels and body iron status.	Iron	41-45	hepcidin antimicrobial peptide	Mus musculus	12-20
22241739-1	2013	BACKGROUND: Hepcidin, the liver-secreted iron regulatory peptide, maintains systemic iron homeostasis in response to several stimuli including dietary iron levels and body iron status.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	12-20
22241739-1	2013	BACKGROUND: Hepcidin, the liver-secreted iron regulatory peptide, maintains systemic iron homeostasis in response to several stimuli including dietary iron levels and body iron status.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	12-20
22241739-1	2013	BACKGROUND: Hepcidin, the liver-secreted iron regulatory peptide, maintains systemic iron homeostasis in response to several stimuli including dietary iron levels and body iron status.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	12-20
22241739-2	2013	In addition, iron metabolism is controlled by several local regulatory mechanisms including IRP and Hif-2alpha activities independently of hepcidin.	Iron	13-17	hepcidin antimicrobial peptide	Mus musculus	139-147
22241739-4	2013	We, therefore, aimed to explore whether Hamp disruption affects iron homeostatic responses to dietary iron deficiency.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	40-44
22241739-7	2013	RESULTS: Two-week iron-deficient diet feeding in Hamp (-/-) mice did not alter serum iron but significantly reduced liver non-heme iron levels.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	49-53
22241739-9	2013	In addition, significant inductive effects of iron-deficient diet on Dcytb and DMT1 mRNA expression in the duodenum were noted with more pronounced effects in Hamp (-/-) mice compared with controls.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	159-163
22241739-10	2013	CONCLUSIONS: Hamp (-/-) mice exhibited a more dramatic increase in the expression of iron transport machinery, which may be responsible for the unaltered serum iron levels upon iron-deficient diet feeding in these mice.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	13-17
22241739-11	2013	Despite the lack of hepcidin, Hamp (-/-) mice can maintain a degree of iron homeostasis in response to altered dietary iron through several hepcidin-independent mechanisms.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	30-34
22241739-11	2013	Despite the lack of hepcidin, Hamp (-/-) mice can maintain a degree of iron homeostasis in response to altered dietary iron through several hepcidin-independent mechanisms.	Iron	119-123	hepcidin antimicrobial peptide	Mus musculus	30-34
22875629-5	2013	We also used this validated assay to measure serum soluble hemojuvelin concentrations in mice receiving an acute low iron or high iron treatment.	Iron	117-121	hemojuvelin BMP co-receptor	Mus musculus	59-70
22875629-5	2013	We also used this validated assay to measure serum soluble hemojuvelin concentrations in mice receiving an acute low iron or high iron treatment.	Iron	130-134	hemojuvelin BMP co-receptor	Mus musculus	59-70
22875629-8	2013	After acute low iron diet treatment in these mice, serum soluble hemojuvelin levels were increased and correlated with lowered serum iron levels and decreased hepatic hepcidin expression.	Iron	16-20	hemojuvelin BMP co-receptor	Mus musculus	65-76
22875629-8	2013	After acute low iron diet treatment in these mice, serum soluble hemojuvelin levels were increased and correlated with lowered serum iron levels and decreased hepatic hepcidin expression.	Iron	16-20	hepcidin antimicrobial peptide	Mus musculus	167-175
22875629-8	2013	After acute low iron diet treatment in these mice, serum soluble hemojuvelin levels were increased and correlated with lowered serum iron levels and decreased hepatic hepcidin expression.	Iron	133-137	hemojuvelin BMP co-receptor	Mus musculus	65-76
22875629-11	2013	This assay may provide a useful tool to elucidate the source and physiological role of serum soluble hemojuvelin in hepcidin regulation and iron metabolism using well-established mouse models of iron-related disorders.	Iron	195-199	hemojuvelin BMP co-receptor	Mus musculus	101-112
23201463-2	2013	MetHb is produced in the RBC by irreversible NO-induced oxidation of the oxygen carrying ferrous ion (Fe(2+)) present in the heme group of the hemoglobin (Hb) molecule to its non-oxygen binding ferric state (Fe(3+)).	Iron	102-104	hemoglobin subunit gamma 2	Homo sapiens	0-5
23201463-2	2013	MetHb is produced in the RBC by irreversible NO-induced oxidation of the oxygen carrying ferrous ion (Fe(2+)) present in the heme group of the hemoglobin (Hb) molecule to its non-oxygen binding ferric state (Fe(3+)).	Iron	208-210	hemoglobin subunit gamma 2	Homo sapiens	0-5
23188716-0	2013	Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway.	Iron	56-60	N-myc downstream regulated 1	Homo sapiens	37-42
23188716-1	2013	The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated by iron chelators and can inhibit cancer cell migration.	Iron	4-8	N-myc downstream regulated 1	Homo sapiens	42-75
23188716-1	2013	The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated by iron chelators and can inhibit cancer cell migration.	Iron	4-8	N-myc downstream regulated 1	Homo sapiens	77-82
23188716-1	2013	The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated by iron chelators and can inhibit cancer cell migration.	Iron	113-117	N-myc downstream regulated 1	Homo sapiens	42-75
23188716-1	2013	The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated by iron chelators and can inhibit cancer cell migration.	Iron	113-117	N-myc downstream regulated 1	Homo sapiens	77-82
23188716-1	2013	The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated by iron chelators and can inhibit cancer cell migration.	Iron	113-117	N-myc downstream regulated 1	Homo sapiens	42-75
23188716-1	2013	The iron-regulated metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), is up-regulated by cellular iron depletion mediated by iron chelators and can inhibit cancer cell migration.	Iron	113-117	N-myc downstream regulated 1	Homo sapiens	77-82
23188716-9	2013	Considering that NDRG1 is up-regulated after cellular iron depletion, novel thiosemicarbazone iron chelators (e.g., di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone) were demonstrated to inhibit ROCK1/pMLC2-modulated actin-filament polymerization, stress fiber assembly, and formation via a mechanism involving NDRG1.	Iron	54-58	N-myc downstream regulated 1	Homo sapiens	17-22
23188716-9	2013	Considering that NDRG1 is up-regulated after cellular iron depletion, novel thiosemicarbazone iron chelators (e.g., di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone) were demonstrated to inhibit ROCK1/pMLC2-modulated actin-filament polymerization, stress fiber assembly, and formation via a mechanism involving NDRG1.	Iron	94-98	N-myc downstream regulated 1	Homo sapiens	17-22
23168578-5	2013	RESULTS: Despite a significantly poorer status at 6 wk, iron-supplemented infants had significantly higher hemoglobin level (Hb): 12.2 (SD = 0.8) g/dl and CHr: 28.3 (SD = 1.4) pg at 6 mo, as compared with nonsupplemented infants, Hb: 11.7 (SD = 1.0) g/dl, P = 0.02 and CHr: 26.5 (SD = 2.5) pg, P &lt; 0.001.	Iron	56-60	chromate resistance; sulfate transport	Homo sapiens	269-272
23168578-8	2013	CONCLUSION: Signs of an iron-restricted erythropoiesis were observed in nonsupplemented infants (birth weight 2,501-3,000 g), and CHr was a useful tool for evaluating iron status.	Iron	167-171	chromate resistance; sulfate transport	Homo sapiens	130-133
23250624-4	2013	In this study, we examined the expression of three Fe homeostasis genes (IRON REGULATED TRANSPORTER1 [IRT1], BASIC HELIX LOOP HELIX39, and FERRITIN1) in Arabidopsis (Arabidopsis thaliana) using promoter:LUCIFERASE transgenic lines.	Iron	51-53	iron-regulated transporter 1	Arabidopsis thaliana	73-100
23250624-4	2013	In this study, we examined the expression of three Fe homeostasis genes (IRON REGULATED TRANSPORTER1 [IRT1], BASIC HELIX LOOP HELIX39, and FERRITIN1) in Arabidopsis (Arabidopsis thaliana) using promoter:LUCIFERASE transgenic lines.	Iron	51-53	iron-regulated transporter 1	Arabidopsis thaliana	102-106
25166195-4	2013	We argue that the gradual change of the spin state over a wide temperature range reveals the importance of multiorbital physics, in particular the competition between the crystal field split Fe 3d orbitals and the Hund"s rule coupling.	Iron	191-193	spindlin 1	Homo sapiens	40-44
23234679-5	2013	The Fe spin is found to be S = 3/2 through computing the antiferromagnetic quantum fluctuation.	Iron	4-6	spindlin 1	Homo sapiens	7-11
23281703-7	2013	Using postnatal 3-, 6-, 9-day old mice, the spatial and temporal expression of Fth in tooth development again indicated the presence of iron in mature ameloblasts and odontoblasts.	Iron	136-140	ferritin heavy polypeptide 1	Mus musculus	79-82
23879587-6	2013	Through the ability of iron chelators to up-regulate NDRG1 expression and affect multiple molecular targets, these agents have the potential to maintain the epithelial phenotype of cancer cells and may lead to improved survival rates for patients with late-stage disease.	Iron	23-27	N-myc downstream regulated 1	Homo sapiens	53-58
23016685-2	2013	The exploration of its function in iron homeostasis was of significance for the understanding of the regulation of hepcidin expression, the master protein in iron control.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	115-123
23016685-2	2013	The exploration of its function in iron homeostasis was of significance for the understanding of the regulation of hepcidin expression, the master protein in iron control.	Iron	158-162	hepcidin antimicrobial peptide	Mus musculus	115-123
21741805-1	2013	Previously, we have shown that TNF-alpha protects iron-exposed J774 macrophages against iron-catalyzed oxidative lysosomal disruption and cell death by increasing reduced glutathione and H-ferritin in cells.	Iron	50-54	ferritin heavy polypeptide 1	Mus musculus	187-197
21741805-1	2013	Previously, we have shown that TNF-alpha protects iron-exposed J774 macrophages against iron-catalyzed oxidative lysosomal disruption and cell death by increasing reduced glutathione and H-ferritin in cells.	Iron	88-92	ferritin heavy polypeptide 1	Mus musculus	187-197
23591893-0	2013	Spin wave-assisted reduction in switching field of highly coercive iron-platinum magnets.	Iron	67-71	spindlin 1	Homo sapiens	0-4
22862424-3	2013	The bacterial expression of human frataxin stimulated maturation of human ferrochelatase, which catalyzes the insertion of iron into protoporphyrin at the last step of heme biosynthesis.	Iron	123-127	ferrochelatase	Homo sapiens	74-88
23418481-10	2013	Compounds that were established to increase FXN gene expression and frataxin levels included several anti-cancer agents, the iron-chelator deferiprone and the phytoalexin resveratrol.	Iron	125-129	frataxin	Mus musculus	44-47
23866594-11	2013	CONCLUSION: Along with the active participation of the morphogenetic proteins (FGF-23 and Klotho) in mineral metabolism and its disturbances in CKD, their role is apparent in the development of cardiovascular events (in particular, through the involvement in the processes of vascular calcification and cardiac remodeling), anemia (through the possible effect on iron metabolism, enhanced ischemia of renal interstitial tissue with impaired Klotho production), and protein-energy insufficiency (through the participation in the processes of inflammation, oxidative stress, and protein synthesis).	Iron	363-367	fibroblast growth factor 23	Homo sapiens	79-85
23866594-11	2013	CONCLUSION: Along with the active participation of the morphogenetic proteins (FGF-23 and Klotho) in mineral metabolism and its disturbances in CKD, their role is apparent in the development of cardiovascular events (in particular, through the involvement in the processes of vascular calcification and cardiac remodeling), anemia (through the possible effect on iron metabolism, enhanced ischemia of renal interstitial tissue with impaired Klotho production), and protein-energy insufficiency (through the participation in the processes of inflammation, oxidative stress, and protein synthesis).	Iron	363-367	klotho	Homo sapiens	90-96
23150669-3	2012	Here, we show that the mammalian nucleotide excision repair protein homolog MMS19 can simultaneously bind probable cytosolic iron-sulfur protein assembly protein CIAO1 and Fe-S proteins, confirming that MMS19 is a central protein of the CIA machinery that brings Fe-S cluster donor proteins and the receiving apoproteins into proximity.	Iron	172-176	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	76-81
23150669-3	2012	Here, we show that the mammalian nucleotide excision repair protein homolog MMS19 can simultaneously bind probable cytosolic iron-sulfur protein assembly protein CIAO1 and Fe-S proteins, confirming that MMS19 is a central protein of the CIA machinery that brings Fe-S cluster donor proteins and the receiving apoproteins into proximity.	Iron	172-176	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	203-208
23041085-0	2012	Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	62-70
23041085-2	2012	Iron homeostasis is tightly governed by the hepcidin-ferroportin axis, of which hepcidin is the master regulator.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	44-52
23041085-2	2012	Iron homeostasis is tightly governed by the hepcidin-ferroportin axis, of which hepcidin is the master regulator.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	80-88
23041085-9	2012	In conclusion, estrogen greatly contributes to iron homeostasis by regulating hepatic hepcidin expression directly through a functional ERE in the promoter region of hepcidin gene.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	86-94
23041085-9	2012	In conclusion, estrogen greatly contributes to iron homeostasis by regulating hepatic hepcidin expression directly through a functional ERE in the promoter region of hepcidin gene.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	166-174
23169664-0	2012	Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia.	Iron	44-48	frataxin	Mus musculus	78-95
23169664-2	2012	This disease is due to decreased expression of the mitochondrial protein, frataxin, which leads to alterations in mitochondrial iron (Fe) metabolism.	Iron	128-132	frataxin	Mus musculus	74-82
23169664-2	2012	This disease is due to decreased expression of the mitochondrial protein, frataxin, which leads to alterations in mitochondrial iron (Fe) metabolism.	Iron	134-136	frataxin	Mus musculus	74-82
23169664-4	2012	Studies using the muscle creatine kinase (MCK) conditional frataxin knockout mouse that mirrors the disease have demonstrated frataxin deletion alters cardiac Fe metabolism.	Iron	159-161	frataxin	Mus musculus	126-134
23169664-7	2012	Furthermore, this study indicates a unique effect of heart and skeletal muscle-specific frataxin deletion on systemic Fe metabolism.	Iron	118-120	frataxin	Mus musculus	88-96
23169664-8	2012	Namely, frataxin deletion induces a signaling mechanism to increase systemic Fe levels and Fe loading in tissues where frataxin expression is intact (i.e., liver, kidney, and spleen).	Iron	77-79	frataxin	Mus musculus	8-16
23169664-8	2012	Namely, frataxin deletion induces a signaling mechanism to increase systemic Fe levels and Fe loading in tissues where frataxin expression is intact (i.e., liver, kidney, and spleen).	Iron	91-93	frataxin	Mus musculus	8-16
23159854-3	2012	NGAL is considered as a siderocalin that is important in the transport of iron.	Iron	74-78	lipocalin 2	Homo sapiens	0-4
23064962-0	2012	Requirement of integrin beta3 for iron transportation during enamel formation.	Iron	34-38	integrin beta 3	Mus musculus	15-29
23064962-9	2012	The results suggested that CD61 regulates the expressions of Slc11a2 and Slc40a1, both of which are involved in iron transportation in epithelial tissues.	Iron	112-116	integrin beta 3	Mus musculus	27-31
22444869-0	2012	High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption.	Iron	21-25	hepcidin antimicrobial peptide	Mus musculus	41-49
22560353-4	2012	Analysis of mechanisms using the iron-depleted cells showed that hepcidin has a direct inhibitory effect on all iron transport proteins we examined.	Iron	33-37	hepcidin antimicrobial peptide	Mus musculus	65-73
22560353-4	2012	Analysis of mechanisms using the iron-depleted cells showed that hepcidin has a direct inhibitory effect on all iron transport proteins we examined.	Iron	112-116	hepcidin antimicrobial peptide	Mus musculus	65-73
22921867-4	2012	Recent work identifying a role for iron/hypoxia pathways in FGF23 physiology and their implications are discussed.	Iron	35-39	fibroblast growth factor 23	Homo sapiens	60-65
23585819-0	2012	Effect of iron chelators on methemoglobin and thrombin preconditioning.	Iron	10-14	hemoglobin subunit gamma 2	Homo sapiens	28-41
23181897-3	2012	It has been found that the catalyst (Fe) thickness affected the morphology of the CNFs on the CF, resulting in different capacitive behaviors of the CNF/CF electrodes.	Iron	37-39	NPHS1 adhesion molecule, nephrin	Homo sapiens	82-85
23012484-8	2012	RESULTS: MR imaging revealed a linear correlation between DeltaR2 and DeltaR2* values of CXCR4-USPIO nanoparticles and the iron concentrations.	Iron	123-127	C-X-C motif chemokine receptor 4	Homo sapiens	89-94
22982461-7	2012	Plaques with Hp2-2 (n=7) had increased hemorrhage (P&lt;0.005), iron content (P&lt;0.001), and reduced CD163 expression (P&lt;0.002) compared with controls (n=14).	Iron	64-68	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	13-18
22990014-0	2012	Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis.	Iron	22-26	hepcidin antimicrobial peptide	Mus musculus	4-12
22990014-1	2012	The deficiency of hepcidin, the hormone that controls iron absorption and its tissue distribution, is the cause of iron overload in nearly all forms of hereditary hemochromatosis and in untransfused iron-loading anemias.	Iron	54-58	hepcidin antimicrobial peptide	Mus musculus	18-26
22990014-1	2012	The deficiency of hepcidin, the hormone that controls iron absorption and its tissue distribution, is the cause of iron overload in nearly all forms of hereditary hemochromatosis and in untransfused iron-loading anemias.	Iron	115-119	hepcidin antimicrobial peptide	Mus musculus	18-26
22990014-1	2012	The deficiency of hepcidin, the hormone that controls iron absorption and its tissue distribution, is the cause of iron overload in nearly all forms of hereditary hemochromatosis and in untransfused iron-loading anemias.	Iron	115-119	hepcidin antimicrobial peptide	Mus musculus	18-26
22990014-3	2012	Here we explore the feasibility of using minihepcidins for the prevention and treatment of iron overload in hepcidin-deficient mice.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	45-53
22990014-5	2012	PR65 was administered by subcutaneous injection daily for 2 weeks to iron-depleted or iron-loaded hepcidin knockout mice.	Iron	69-73	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22990014-5	2012	PR65 was administered by subcutaneous injection daily for 2 weeks to iron-depleted or iron-loaded hepcidin knockout mice.	Iron	86-90	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22990014-5	2012	PR65 was administered by subcutaneous injection daily for 2 weeks to iron-depleted or iron-loaded hepcidin knockout mice.	Iron	86-90	hepcidin antimicrobial peptide	Mus musculus	98-106
22990014-6	2012	PR65 administration to iron-depleted mice prevented liver iron loading, decreased heart iron levels, and caused the expected iron retention in the spleen and duodenum.	Iron	23-27	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22990014-6	2012	PR65 administration to iron-depleted mice prevented liver iron loading, decreased heart iron levels, and caused the expected iron retention in the spleen and duodenum.	Iron	58-62	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22990014-6	2012	PR65 administration to iron-depleted mice prevented liver iron loading, decreased heart iron levels, and caused the expected iron retention in the spleen and duodenum.	Iron	58-62	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22990014-6	2012	PR65 administration to iron-depleted mice prevented liver iron loading, decreased heart iron levels, and caused the expected iron retention in the spleen and duodenum.	Iron	58-62	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22990014-7	2012	At high doses, PR65 treatment also caused anemia because of profound iron restriction.	Iron	69-73	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	15-19
22990014-8	2012	PR65 administration to hepcidin knockout mice with pre-existing iron overload had a more moderate effect and caused partial redistribution of iron from the liver to the spleen.	Iron	64-68	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22990014-8	2012	PR65 administration to hepcidin knockout mice with pre-existing iron overload had a more moderate effect and caused partial redistribution of iron from the liver to the spleen.	Iron	142-146	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	0-4
22581006-1	2012	BACKGROUND: We and others have shown previously that over-expression of hepcidin antimicrobial peptide, independently of inflammation, induces several features of anemia of inflammation and chronic disease, including hypoferremia, sequestration of iron stores and iron-restricted erythropoiesis.	Iron	248-252	hepcidin antimicrobial peptide	Mus musculus	72-80
22581006-1	2012	BACKGROUND: We and others have shown previously that over-expression of hepcidin antimicrobial peptide, independently of inflammation, induces several features of anemia of inflammation and chronic disease, including hypoferremia, sequestration of iron stores and iron-restricted erythropoiesis.	Iron	264-268	hepcidin antimicrobial peptide	Mus musculus	72-80
22581006-2	2012	Because the iron-restricted erythropoiesis evident in hepcidin transgenic mice differs from the normocytic, normochromic anemia most often observed in anemia of inflammation, we tested the hypothesis that chronic inflammation may contribute additional features to anemia of inflammation which continue to impair erythropoiesis following the acute phase of inflammation in which hepcidin is active.	Iron	12-16	hepcidin antimicrobial peptide	Mus musculus	54-62
22581006-3	2012	DESIGN AND METHODS: We compared erythropoiesis and iron handling in mice with turpentine-induced sterile abscesses with erythropoiesis and iron handling in hepcidin transgenic mice.	Iron	139-143	hepcidin antimicrobial peptide	Mus musculus	156-164
23098062-0	2012	FGF23 is correlated with iron status but not with inflammation and decreases after iron supplementation: a supplementation study.	Iron	25-29	fibroblast growth factor 23	Homo sapiens	0-5
23098062-0	2012	FGF23 is correlated with iron status but not with inflammation and decreases after iron supplementation: a supplementation study.	Iron	83-87	fibroblast growth factor 23	Homo sapiens	0-5
23098062-1	2012	UNLABELLED:  BACKGROUND: Recent studies have described relationships between iron status and fibroblast growth factor-23 (FGF23) but the possible confounding effects of inflammation on iron status have not been considered.	Iron	77-81	fibroblast growth factor 23	Homo sapiens	93-120
23098062-1	2012	UNLABELLED:  BACKGROUND: Recent studies have described relationships between iron status and fibroblast growth factor-23 (FGF23) but the possible confounding effects of inflammation on iron status have not been considered.	Iron	77-81	fibroblast growth factor 23	Homo sapiens	122-127
23098062-2	2012	The aims of this study were a) to consider a relationship between FGF23 and inflammation b) to identify relationships between iron status and FGF23 whilst correcting for inflammation and c) to assess the relationship between changes in FGF23 and iron status after supplementation.	Iron	126-130	fibroblast growth factor 23	Homo sapiens	142-147
23098062-2	2012	The aims of this study were a) to consider a relationship between FGF23 and inflammation b) to identify relationships between iron status and FGF23 whilst correcting for inflammation and c) to assess the relationship between changes in FGF23 and iron status after supplementation.	Iron	126-130	fibroblast growth factor 23	Homo sapiens	142-147
23098062-5	2012	This study identified cross-sectional and longitudinal relationships between FGF23, inflammation (C-reactive protein (CRP)) and iron status (ferritin, haemoglobin, and zinc protoporphyrin).	Iron	128-132	fibroblast growth factor 23	Homo sapiens	77-82
23098062-8	2012	At baseline, all markers of iron status were significantly correlated with FGF23.	Iron	28-32	fibroblast growth factor 23	Homo sapiens	75-80
23098062-12	2012	CONCLUSIONS: Iron status rather than inflammation is a negative predictor of plasma FGF23 concentration.	Iron	13-17	fibroblast growth factor 23	Homo sapiens	84-89
23098062-13	2012	Improvements in iron status following iron supplementation are associated with a significant decrease in FGF23 concentration.	Iron	16-20	fibroblast growth factor 23	Homo sapiens	105-110
23098062-13	2012	Improvements in iron status following iron supplementation are associated with a significant decrease in FGF23 concentration.	Iron	38-42	fibroblast growth factor 23	Homo sapiens	105-110
22915593-1	2012	Yeast respond to increased cytosolic iron by activating the transcription factor Yap5 increasing transcription of CCC1, which encodes a vacuolar iron importer.	Iron	37-41	Ccc1p	Saccharomyces cerevisiae S288C	114-118
22915593-1	2012	Yeast respond to increased cytosolic iron by activating the transcription factor Yap5 increasing transcription of CCC1, which encodes a vacuolar iron importer.	Iron	145-149	Ccc1p	Saccharomyces cerevisiae S288C	114-118
22915593-3	2012	We demonstrated that mutation or reduced expression of other genes involved in mitochondrial iron-sulfur cluster synthesis (YFH1, ISU1) prevented induction of the Yap5 response.	Iron	93-97	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	130-134
23039828-1	2012	BACKGROUND: Friedreich"s ataxia (FRDA) is a neurodegenerative disease caused by deficiency of the mitochondrial iron chaperone frataxin (Fxn).	Iron	112-116	frataxin	Mus musculus	33-37
23039828-1	2012	BACKGROUND: Friedreich"s ataxia (FRDA) is a neurodegenerative disease caused by deficiency of the mitochondrial iron chaperone frataxin (Fxn).	Iron	112-116	frataxin	Mus musculus	127-135
23039828-1	2012	BACKGROUND: Friedreich"s ataxia (FRDA) is a neurodegenerative disease caused by deficiency of the mitochondrial iron chaperone frataxin (Fxn).	Iron	112-116	frataxin	Mus musculus	137-140
23230575-38	2012	However, it may be that CHr and %HYPO have better predictive ability for a response to IV iron treatment than classical markers (TSAT &lt;20 or ferritin &lt;100 ng/mL) in HD CKD patients.	Iron	90-94	chromate resistance; sulfate transport	Homo sapiens	24-27
23230575-39	2012	In addition, results from two RCTs showed a reduction in the number of iron status tests and resulting IV iron treatments administered to patients whose iron management was guided by CHr, compared with those guided by TSAT or ferritin.	Iron	71-75	chromate resistance; sulfate transport	Homo sapiens	183-186
23230575-39	2012	In addition, results from two RCTs showed a reduction in the number of iron status tests and resulting IV iron treatments administered to patients whose iron management was guided by CHr, compared with those guided by TSAT or ferritin.	Iron	106-110	chromate resistance; sulfate transport	Homo sapiens	183-186
23230575-39	2012	In addition, results from two RCTs showed a reduction in the number of iron status tests and resulting IV iron treatments administered to patients whose iron management was guided by CHr, compared with those guided by TSAT or ferritin.	Iron	106-110	chromate resistance; sulfate transport	Homo sapiens	183-186
23230575-40	2012	These results suggest that CHr may reduce potential harms from IV iron treatment by lowering the frequency of iron testing, although the evidence for the potential harms associated with testing or test-associated treatment is insufficient.	Iron	66-70	chromate resistance; sulfate transport	Homo sapiens	27-30
23230575-40	2012	These results suggest that CHr may reduce potential harms from IV iron treatment by lowering the frequency of iron testing, although the evidence for the potential harms associated with testing or test-associated treatment is insufficient.	Iron	110-114	chromate resistance; sulfate transport	Homo sapiens	27-30
22580926-5	2012	Elevated levels of iron as well as other minerals in feces of Irp2-/- mice compared to wild type and Hfe-/- mice were observed.	Iron	19-23	iron responsive element binding protein 2	Mus musculus	62-66
22988949-3	2012	In the trinuclear complexes, the halide-bearing iron site sits in approximate trigonal-bipyramidal (tbp) geometry, formed by two ((Ph)L) anilides and an exogenous solvent molecule.	Iron	48-52	TATA-box binding protein	Homo sapiens	100-103
22732705-6	2012	A differential release of arachidonic acid (AA) and palmitic acid (PAL) catalyzed by cPLA(2) and iPLA(2) activities, respectively, was also observed in microsomal and cytosolic fractions obtained from retinas incubated with iron.	Iron	224-228	phospholipase A2 group IVA	Homo sapiens	85-92
22237814-17	2012	GLI1 mRNA level was increased under iron exposure.	Iron	36-40	GLI family zinc finger 1	Homo sapiens	0-4
22829592-7	2012	Fe(2+) stimulates Lys(63)-linked polyubiquitination (polyUb) of TRAF6 in caveosomes, and a dominant negative K63R mutant of ubiquitin or SOD prevents iron-induced TRAF6 polyUb and TAK1 activation.	Iron	150-154	TNF receptor associated factor 6	Rattus norvegicus	64-69
22829592-7	2012	Fe(2+) stimulates Lys(63)-linked polyubiquitination (polyUb) of TRAF6 in caveosomes, and a dominant negative K63R mutant of ubiquitin or SOD prevents iron-induced TRAF6 polyUb and TAK1 activation.	Iron	150-154	TNF receptor associated factor 6	Rattus norvegicus	163-168
22829592-7	2012	Fe(2+) stimulates Lys(63)-linked polyubiquitination (polyUb) of TRAF6 in caveosomes, and a dominant negative K63R mutant of ubiquitin or SOD prevents iron-induced TRAF6 polyUb and TAK1 activation.	Iron	150-154	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	180-184
22658830-4	2012	With 0.98 mM H(2)O(2) and 0.4 g L(-1) Fe(3)O(4)@ALG/Fe, 100% of NOF and 90% of TOC is removed within 60 min, and the fluorine element in NOF molecule changes into F(-) ions within 1 min, indicating that NOF degradation in this Fenton-like reaction is performed through direct defluorination pathway.	Iron	38-40	mitochondrial ribosomal protein L49	Homo sapiens	64-67
22658830-4	2012	With 0.98 mM H(2)O(2) and 0.4 g L(-1) Fe(3)O(4)@ALG/Fe, 100% of NOF and 90% of TOC is removed within 60 min, and the fluorine element in NOF molecule changes into F(-) ions within 1 min, indicating that NOF degradation in this Fenton-like reaction is performed through direct defluorination pathway.	Iron	38-40	mitochondrial ribosomal protein L49	Homo sapiens	137-140
22658830-4	2012	With 0.98 mM H(2)O(2) and 0.4 g L(-1) Fe(3)O(4)@ALG/Fe, 100% of NOF and 90% of TOC is removed within 60 min, and the fluorine element in NOF molecule changes into F(-) ions within 1 min, indicating that NOF degradation in this Fenton-like reaction is performed through direct defluorination pathway.	Iron	38-40	mitochondrial ribosomal protein L49	Homo sapiens	137-140
22847425-11	2012	Given that MCO1 orthologues are present in all insect genomes analyzed to date, this discovery is an important step toward understanding iron metabolism in insects.	Iron	137-141	Multicopper oxidase 1	Drosophila melanogaster	11-15
22743658-0	2012	Analysis of ATP13A2 in large neurodegeneration with brain iron accumulation (NBIA) and dystonia-parkinsonism cohorts.	Iron	58-62	ATPase cation transporting 13A2	Homo sapiens	12-19
22743658-3	2012	More recently, evidence of iron deposition in the caudate and putamen have been reported in patients with ATP13A2 mutations.	Iron	27-31	ATPase cation transporting 13A2	Homo sapiens	106-113
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	147-151	lipocalin 2	Homo sapiens	92-96
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	147-151	lipocalin 2	Homo sapiens	116-120
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	194-198	lipocalin 2	Homo sapiens	92-96
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Iron	194-198	lipocalin 2	Homo sapiens	116-120
22513004-7	2012	By sequestering iron-laden siderophores, Lcn2 deprives bacteria of a vital nutrient and thus inhibits their growth (bacteriostatic effect).	Iron	16-20	lipocalin 2	Homo sapiens	41-45
22513004-10	2012	By transporting iron into and out of the cell, NGAL also regulates iron responsive genes.	Iron	16-20	lipocalin 2	Homo sapiens	47-51
22513004-10	2012	By transporting iron into and out of the cell, NGAL also regulates iron responsive genes.	Iron	67-71	lipocalin 2	Homo sapiens	47-51
22749870-1	2012	Inhibition of intestinal brush border DMT1 offers a novel therapeutic approach to the prevention and treatment of disorders of iron overload.	Iron	127-131	RoBo-1	Rattus norvegicus	38-42
22544439-1	2012	Hepcidin is a key regulator of iron recycling by macrophages that is synthesized mainly by hepatocytes but also by macrophages.	Iron	31-35	hepcidin antimicrobial peptide	Mus musculus	0-8
22544439-6	2012	We conclude that hepcidin expression in macrophages is regulated mainly through TLR2 and TLR4 receptors via the MyD88-dependent signaling pathway and that autocrine regulation of iron accumulation in macrophages by hepcidin may affect the levels of proinflammatory cytokine production.	Iron	179-183	hepcidin antimicrobial peptide	Mus musculus	215-223
22198484-1	2012	Hepcidin 1 (Hepc1) is a peptide hormone secreted by the liver in response to iron loading.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	0-10
22198484-1	2012	Hepcidin 1 (Hepc1) is a peptide hormone secreted by the liver in response to iron loading.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	12-17
22198484-8	2012	Furthermore, transgenic expression of Hepc1 restored the iron level and phosphorylation level of extracellular signal-regulated kinases 1/2 (ERK1/2) in the heart tissues of cTnT(R141W) transgenic mice.	Iron	57-61	hepcidin antimicrobial peptide	Mus musculus	38-43
22198484-9	2012	It was concluded that transgenic expression of Hepc1 compensated for the loss of Hepc1 expression and the release of iron and brought about a marked improvement in the pathologic phenotype of DCM, in which the ERK1/2 signal pathway might play an important role.	Iron	117-121	hepcidin antimicrobial peptide	Mus musculus	47-52
22576580-8	2012	CONCLUSIONS: This study provides some preliminary evidence regarding a role of diet, specifically iron and antimony, in the etiology of BRCA1-associated breast cancer.	Iron	98-102	BRCA1 DNA repair associated	Homo sapiens	136-141
22616633-1	2012	Iron (Fe(0) ) corrosion in anoxic environments (e.g. inside pipelines), a process entailing considerable economic costs, is largely influenced by microorganisms, in particular sulfate-reducing bacteria (SRB).	Iron	0-4	chaperonin containing TCP1 subunit 4	Homo sapiens	203-206
22616633-1	2012	Iron (Fe(0) ) corrosion in anoxic environments (e.g. inside pipelines), a process entailing considerable economic costs, is largely influenced by microorganisms, in particular sulfate-reducing bacteria (SRB).	Iron	6-11	chaperonin containing TCP1 subunit 4	Homo sapiens	203-206
22616633-4	2012	Here we studied peculiar marine SRB that grew lithotrophically with metallic iron as the only electron donor.	Iron	77-81	chaperonin containing TCP1 subunit 4	Homo sapiens	32-35
22683637-4	2012	The upregulation of CTR2 induced by iron depletion was abrogated by the genetic deletion of either Mac1p or iron-sensing transcription factor Aft1p.	Iron	36-40	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	142-147
22496346-6	2012	The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules.	Iron	56-60	transferrin	Mus musculus	97-108
22496346-6	2012	The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules.	Iron	251-255	transferrin	Mus musculus	97-108
22517766-1	2012	Hepcidin is a hepatocellular hormone that inhibits the release of iron from certain cell populations, including enterocytes and reticuloendothelial cells.	Iron	66-70	hepcidin antimicrobial peptide	Mus musculus	0-8
22517766-2	2012	The regulation of hepcidin (HAMP) gene expression by iron status is mediated in part by the signaling molecule bone morphogenetic protein 6 (BMP6).	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	18-26
22517766-2	2012	The regulation of hepcidin (HAMP) gene expression by iron status is mediated in part by the signaling molecule bone morphogenetic protein 6 (BMP6).	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	28-32
22683786-6	2012	The putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein.	Iron	152-156	cytosolic iron-sulfur assembly component 1	Homo sapiens	131-136
22497726-4	2012	Using MyD88-deficient and TRIF-deficient mice, we show that MyD88 and TRIF signaling pathways are critical for up-regulation by lipopolysaccharide (LPS) of the iron regulator hepcidin.	Iron	160-164	toll-like receptor adaptor molecule 2	Mus musculus	26-30
22497726-4	2012	Using MyD88-deficient and TRIF-deficient mice, we show that MyD88 and TRIF signaling pathways are critical for up-regulation by lipopolysaccharide (LPS) of the iron regulator hepcidin.	Iron	160-164	myeloid differentiation primary response gene 88	Mus musculus	6-11
22497726-4	2012	Using MyD88-deficient and TRIF-deficient mice, we show that MyD88 and TRIF signaling pathways are critical for up-regulation by lipopolysaccharide (LPS) of the iron regulator hepcidin.	Iron	160-164	toll-like receptor adaptor molecule 2	Mus musculus	70-74
22497726-4	2012	Using MyD88-deficient and TRIF-deficient mice, we show that MyD88 and TRIF signaling pathways are critical for up-regulation by lipopolysaccharide (LPS) of the iron regulator hepcidin.	Iron	160-164	hepcidin antimicrobial peptide	Mus musculus	175-183
22497726-5	2012	In addition, MyD88 signaling is required for the induction of lipocalin 2 secretion and iron sequestration in the spleen.	Iron	88-92	myeloid differentiation primary response gene 88	Mus musculus	13-18
22435664-6	2012	These findings indicate that oxidative stress caused by a SOD1 deficiency probably enhances the phosphorylation of and the conversion of IRP1 to the IRE-binding form, which may accelerate the reabsorption of iron by renal tubular cells.	Iron	208-212	aconitase 1	Mus musculus	137-141
22467784-6	2012	The iron chelation- and oxidative-stress-deficient responses of this mutant were corrected when complemented with either the ATCC 19606(T) parental allele or the Escherichia coli MG1655 nfuA ortholog.	Iron	4-8	iron-sulfur cluster carrier protein NfuA	Escherichia coli str. K-12 substr. MG1655	186-190
22467784-7	2012	Furthermore, electron paramagnetic resonance (EPR) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analyses showed that the ATCC 19606(T) NfuA ortholog has iron-binding properties compatible with the formation of [Fe-S] cluster protein.	Iron	178-182	iron-sulfur cluster carrier protein NfuA	Escherichia coli str. K-12 substr. MG1655	160-164
22467784-7	2012	Furthermore, electron paramagnetic resonance (EPR) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analyses showed that the ATCC 19606(T) NfuA ortholog has iron-binding properties compatible with the formation of [Fe-S] cluster protein.	Iron	236-240	iron-sulfur cluster carrier protein NfuA	Escherichia coli str. K-12 substr. MG1655	160-164
22467784-8	2012	Ex vivo and in vivo assays using human epithelial cells and Galleria mellonella, respectively, showed that NfuA is critical for bacterial growth independent of their capacity to acquire iron or the presence of excess of free iron.	Iron	225-229	iron-sulfur cluster carrier protein NfuA	Escherichia coli str. K-12 substr. MG1655	107-111
22467784-9	2012	Taken together, these observations indicate that the A. baumannii NfuA ortholog plays a role in intracellular iron utilization and protection from oxidative-stress responses that this pathogen could encounter during the infection of the human host.	Iron	110-114	iron-sulfur cluster carrier protein NfuA	Escherichia coli str. K-12 substr. MG1655	66-70
22575541-3	2012	Most of this iron is moved across the enterocyte brush border membrane by the iron transporter divalent metal-ion transporter 1, a process enhanced by the prior reduction of the iron by duodenal cytochrome B and possibly other reductases.	Iron	13-17	cytochrome b reductase 1	Homo sapiens	186-207
22575541-3	2012	Most of this iron is moved across the enterocyte brush border membrane by the iron transporter divalent metal-ion transporter 1, a process enhanced by the prior reduction of the iron by duodenal cytochrome B and possibly other reductases.	Iron	78-82	cytochrome b reductase 1	Homo sapiens	186-207
22580691-0	2012	Looking for the hub in Fe signaling.	Iron	23-25	ELAV like RNA binding protein 2	Homo sapiens	16-19
22704260-0	2012	C19orf12 and FA2H mutations are rare in Italian patients with neurodegeneration with brain iron accumulation.	Iron	91-95	chromosome 19 open reading frame 12	Homo sapiens	0-8
22586079-8	2012	The regulation by metabolic iron binding to IRE-RNA to decrease inhibitor protein (IRP) binding and increase activator protein (eIF4F) binding identifies IRE-RNA as a riboregulator.	Iron	28-32	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	128-133
22465937-12	2012	By contrast, the end product, biliverdin was less fitting to the active site with the critical central methylene bridge distanced from the CYP2A6 haem iron facilitating its release.	Iron	151-155	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	139-145
22562611-0	2012	Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism.	Iron	82-86	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	32-36
22562611-0	2012	Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism.	Iron	82-86	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	65-69
22562611-5	2012	Phenotypic characterization of At-NEET revealed a key role for this protein in plant development, senescence, reactive oxygen homeostasis, and Fe metabolism.	Iron	143-145	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	34-38
22562611-6	2012	A role in Fe metabolism was further supported by biochemical and cell biology studies of At-NEET in plant and mammalian cells, as well as mutational analysis of its cluster binding domain.	Iron	10-12	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	92-96
22562611-7	2012	Our findings support the hypothesis that NEET proteins have an ancient role in cells associated with Fe metabolism.	Iron	101-103	2 iron, 2 sulfur cluster binding protein	Arabidopsis thaliana	41-45
22415338-5	2012	The effective coordination number of the nitrogen atoms of the ligands around the iron atom has been identified as the order parameter driving the quasi-reversible low-spin to high-spin transition in the crystal.	Iron	82-86	spindlin 1	Homo sapiens	168-172
22415338-5	2012	The effective coordination number of the nitrogen atoms of the ligands around the iron atom has been identified as the order parameter driving the quasi-reversible low-spin to high-spin transition in the crystal.	Iron	82-86	spindlin 1	Homo sapiens	181-185
22342521-3	2012	In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human age-related macular degeneration; however, the role of Heph and Cp in the individual retinal cells is unclear.	Iron	114-118	hephaestin	Homo sapiens	84-88
22075378-1	2012	The innate immune molecule Lipocalin 2 (LCN2) was initially shown to combat bacterial infection by binding bacterial siderophores, hence impairing microbial iron sequestration.	Iron	157-161	lipocalin 2	Homo sapiens	27-38
22075378-1	2012	The innate immune molecule Lipocalin 2 (LCN2) was initially shown to combat bacterial infection by binding bacterial siderophores, hence impairing microbial iron sequestration.	Iron	157-161	lipocalin 2	Homo sapiens	40-44
22075378-3	2012	Herein, we discuss emerging evidence that substantiates two functional roles for LCN2 in cancer: promotion of the epithelial-to-mesenchymal transition (EMT) that facilitates an invasive phenotype and metastasis, and sequestration of iron that results in cell survival and tumorigenesis.	Iron	233-237	lipocalin 2	Homo sapiens	81-85
22306468-0	2012	Interaction of J-protein co-chaperone Jac1 with Fe-S scaffold Isu is indispensable in vivo and conserved in evolution.	Iron	48-52	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	38-42
22306468-1	2012	The ubiquitous mitochondrial J-protein Jac1, called HscB in Escherichia coli, and its partner Hsp70 play a critical role in the transfer of Fe-S clusters from the scaffold protein Isu to recipient proteins.	Iron	140-144	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	39-43
22306468-8	2012	Thus, we conclude that the Jac1:Isu1 interaction plays an indispensable role in the essential process of mitochondrial Fe-S cluster biogenesis.	Iron	119-123	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	27-31
22822413-3	2012	This study investigated the effect of iron on amyloid beta (Abeta)-mediated brain injury.	Iron	38-42	amyloid beta precursor protein	Rattus norvegicus	60-65
22822413-11	2012	Expression of tTG increased markedly in the iron+Abeta group (p&lt;0.05) and treatment with a tTG inhibitor reduced brain edema (p&lt;0.05) and reduced degenerating neurons (124+-25 vs. 249+-50/mm(2) in vehicle-treated group, p&lt;0.05).	Iron	44-48	amyloid beta precursor protein	Rattus norvegicus	49-54
22463564-2	2012	By placing manganese phthalocyanine (MnPc) molecules on Fe-supported Pb islands, a Kondo system is devised which is exchange coupled to a magnetic substrate via conduction electrons in Pb, inducing spin splitting of the Kondo resonance.	Iron	56-58	spindlin 1	Homo sapiens	198-202
22308374-3	2012	Here we report that reduction of the heme iron to the ferrous [Fe(II)] state in DGCR8 abolishes the pri-miRNA processing activity.	Iron	42-46	DGCR8 microprocessor complex subunit	Homo sapiens	80-85
22159020-1	2012	PURPOSE: The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneration.	Iron	13-17	transferrin	Mus musculus	26-37
22101253-0	2012	Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.	Iron	74-78	ferredoxin 1	Homo sapiens	11-30
22089858-8	2012	The resulting iron-induced cell alterations were characterized by cell polarization and formation of membrane cuplike and microvilli-like projections abundant with ICAM-1, caveolin-1, and F-actin.	Iron	14-18	intercellular adhesion molecule 1	Rattus norvegicus	164-170
21666721-0	2012	Modulation of Wnt/beta-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.	Iron	72-76	catenin (cadherin associated protein), beta 1	Mus musculus	18-30
21666721-5	2012	HQBA may inhibit an iron-dependent factor that regulates cell-type-specific beta-catenin-driven transcription.	Iron	20-24	catenin (cadherin associated protein), beta 1	Mus musculus	76-88
22094461-7	2012	Fes activity is elevated with PLD2 overexpression, phosphatidic acid or phosphatidylinositol bisphosphate.	Iron	0-3	phospholipase D2	Homo sapiens	30-34
22094461-8	2012	Co-immunoprecipitation indicates a close PLD2-Fes physical interaction that is negated by a Fes-R483K mutant that incapacitates its Src homology 2 domain.	Iron	46-49	phospholipase D2	Homo sapiens	41-45
22094461-9	2012	All these suggest for the first time the following mechanism: mTOR/S6K down-regulation PLD2 overexpression PLD2/Fes association phosphatidic acid-led activation of Fes kinase granulocytic differentiation.	Iron	112-115	phospholipase D2	Homo sapiens	87-91
21936771-7	2012	In mitochondria carrying the mutant Isu1 and no frataxin, Fe-S cluster enzyme activities were improved.	Iron	58-62	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	36-40
22652747-1	2012	Neutrophil gelatinase-associated lipocalin (NGAL), a protein involved in iron handling, has been recognized as a marker of inflammation.	Iron	73-77	lipocalin 2	Homo sapiens	0-42
22652747-1	2012	Neutrophil gelatinase-associated lipocalin (NGAL), a protein involved in iron handling, has been recognized as a marker of inflammation.	Iron	73-77	lipocalin 2	Homo sapiens	44-48
22062951-1	2012	A majority of cells obtain of transferrin (Tf) bound iron via transferrin receptor 1 (TfR1) or by transferrin receptor 2 (TfR2) in hepatocytes.	Iron	53-57	transferrin receptor protein 1	Cricetulus griseus	86-90
22062951-2	2012	Our study establishes that cells are capable of acquiring transferrin iron by an alternate pathway via GAPDH.	Iron	70-74	glyceraldehyde-3-phosphate dehydrogenase	Cricetulus griseus	103-108
22062951-3	2012	These findings demonstrate that upon iron depletion, GAPDH functions as a preferred receptor for transferrin rather than TfR1 in some but not all cell types.	Iron	37-41	glyceraldehyde-3-phosphate dehydrogenase	Cricetulus griseus	53-58
22062951-5	2012	A knockdown of GAPDH in these cells resulted in a decrease of not only transferrin binding but also associated iron uptake.	Iron	111-115	glyceraldehyde-3-phosphate dehydrogenase	Cricetulus griseus	15-20
22062951-9	2012	Our findings provide an explanation for the detailed role of GAPDH mediated transferrin uptake as an alternate route by which cells acquire iron.	Iron	140-144	glyceraldehyde-3-phosphate dehydrogenase	Cricetulus griseus	61-66
22121494-1	2012	Hepcidin, a key regulator of iron metabolism, is activated by bone morphogenetic proteins (BMPs).	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	0-8
23235391-1	2012	BACKGROUND: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients.	Iron	107-111	lipocalin 2	Homo sapiens	12-54
23235391-1	2012	BACKGROUND: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients.	Iron	107-111	lipocalin 2	Homo sapiens	56-60
22047986-7	2012	Reversely, iron chelation could reduce eIF3 p170 translation.	Iron	11-15	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	39-48
23095372-5	2012	RESULTS: CD163-expressing macrophages, HO-1 and NADPH-p22 expression were located in areas surrounding tubules with iron deposits and filled with erythrocyte casts.	Iron	116-120	CD163 molecule	Homo sapiens	9-14
22952941-0	2012	The PICALM protein plays a key role in iron homeostasis and cell proliferation.	Iron	39-43	phosphatidylinositol binding clathrin assembly protein	Mus musculus	4-10
22952941-3	2012	Inactivating and hypomorphic Picalm mutations in mice cause different degrees of severity of anemia, abnormal iron metabolism, growth retardation and shortened lifespan.	Iron	110-114	phosphatidylinositol binding clathrin assembly protein	Mus musculus	29-35
22952941-6	2012	Murine embryonic fibroblasts (MEFs) that are deficient in PICALM display several characteristics of iron deficiency (increased surface TfR expression, decreased intracellular iron levels, and reduced cellular proliferation), all of which are rescued by retroviral PICALM expression.	Iron	100-104	phosphatidylinositol binding clathrin assembly protein	Mus musculus	58-64
22952941-7	2012	The proliferation defect of cells that lack PICALM results, at least in part, from insufficient iron uptake, since it can be corrected by iron supplementation.	Iron	96-100	phosphatidylinositol binding clathrin assembly protein	Mus musculus	44-50
22952941-7	2012	The proliferation defect of cells that lack PICALM results, at least in part, from insufficient iron uptake, since it can be corrected by iron supplementation.	Iron	138-142	phosphatidylinositol binding clathrin assembly protein	Mus musculus	44-50
22952941-8	2012	Moreover, PICALM-deficient cells are particularly sensitive to iron chelation.	Iron	63-67	phosphatidylinositol binding clathrin assembly protein	Mus musculus	10-16
22952941-9	2012	Taken together, these data reveal that PICALM plays a critical role in iron homeostasis, and offer new perspectives into the pathogenesis of PICALM-associated diseases.	Iron	71-75	phosphatidylinositol binding clathrin assembly protein	Mus musculus	39-45
22723983-14	2012	Iron may have mediated Drosha/DGCR8/heme-mediated processing of microRNAs.	Iron	0-4	drosha ribonuclease III	Homo sapiens	23-29
22723983-14	2012	Iron may have mediated Drosha/DGCR8/heme-mediated processing of microRNAs.	Iron	0-4	DGCR8 microprocessor complex subunit	Homo sapiens	30-35
23049400-3	2012	OBJECTIVE: The aim of this study was to estimate the frequency of the GSTM1 and GSTT1 genotypes in sickle cell disease patients and their effect on iron status.	Iron	148-152	glutathione S-transferase theta 1	Homo sapiens	80-85
22678215-1	2012	Subsurface arsenic and iron removal (SAR/SIR) is a novel technology to remove arsenic, iron and other groundwater components by using the subsoil.	Iron	23-27	sarcosine dehydrogenase	Homo sapiens	37-40
22678215-1	2012	Subsurface arsenic and iron removal (SAR/SIR) is a novel technology to remove arsenic, iron and other groundwater components by using the subsoil.	Iron	87-91	sarcosine dehydrogenase	Homo sapiens	37-40
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Iron	120-124	hepcidin antimicrobial peptide	Mus musculus	157-165
21545274-3	2011	Recent investigations have identified a host of mitochondrial proteins (e.g., mitochondrial ferritin; mitoferrins 1 and 2; ABCBs 6, 7, and 10; and frataxin) that may play roles in the homeostasis of mitochondrial iron.	Iron	213-217	solute carrier family 25 member 37	Homo sapiens	102-121
22016389-6	2011	The HypA-HycE complex was not detected in the absence of the HypC or HypD proteins, involved in the preceding iron insertion step, and this interaction is enhanced by nickel brought into the cell by the NikABCDE membrane transporter.	Iron	110-114	hypA	Escherichia coli	4-8
22016389-8	2011	These results support the hypothesis that HypA acts as a scaffold for assembly of the nickel insertion proteins with the hydrogenase precursor protein after delivery of the iron center.	Iron	173-177	hypA	Escherichia coli	42-46
22031863-1	2011	STEAP3/TSAP6 encodes a ferrireductase that is involved in the acquisition of iron by developing erythroblasts and steap3/tsap6 null-mice display severe microcytic anemia.	Iron	77-81	STEAP family member 3	Mus musculus	0-6
22031863-1	2011	STEAP3/TSAP6 encodes a ferrireductase that is involved in the acquisition of iron by developing erythroblasts and steap3/tsap6 null-mice display severe microcytic anemia.	Iron	77-81	STEAP family member 3	Mus musculus	7-12
21965683-2	2011	Most of the neuroglobin is present in a hexacoordinate state with proximal and distal histidines in the heme pocket directly bound to the heme iron.	Iron	143-147	neuroglobin	Homo sapiens	12-23
21976667-3	2011	Previous reports have demonstrated that NDRG1 is strongly up-regulated by chemical iron chelators and hypoxia, yet its regulation by the free radical nitric oxide (( )NO) has never been demonstrated.	Iron	83-87	N-myc downstream regulated 1	Homo sapiens	40-45
21976667-8	2011	Augmenting the chelatable iron pool abolished ( )NO-mediated NDRG1 expression and the associated phenotypic effects.	Iron	26-30	N-myc downstream regulated 1	Homo sapiens	61-66
21976667-9	2011	These data, in summary, reveal a link between ( )NO, chelatable iron, and regulation of NDRG1 expression and signaling in tumor cells.	Iron	64-68	N-myc downstream regulated 1	Homo sapiens	88-93
21987576-7	2011	Isa1 and Isa2 proteins are shown to bind iron in vivo, yet the Isa1-Isa2-bound iron was not needed as a donor for de novo assembly of the [2Fe-2S] cluster on the general Fe/S scaffold proteins Isu1-Isu2.	Iron	41-45	iron-sulfur cluster assembly 1	Homo sapiens	0-4
21987576-7	2011	Isa1 and Isa2 proteins are shown to bind iron in vivo, yet the Isa1-Isa2-bound iron was not needed as a donor for de novo assembly of the [2Fe-2S] cluster on the general Fe/S scaffold proteins Isu1-Isu2.	Iron	79-83	iron-sulfur cluster assembly 1	Homo sapiens	63-67
22053949-0	2011	Iron-catalyzed oxidation of tertiary amines: synthesis of beta-1,3-dicarbonyl aldehydes by three-component C-C couplings.	Iron	0-4	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	58-66
22053949-1	2011	beta-1,3-Dicarbonyl aldehydes were synthesized by iron-catalyzed oxidative reactions between 1,3-dicarbonyl compounds and two molecules of tertiary amines in the presence of tert-butyl hydroperoxide (TBHP).	Iron	50-54	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	0-8
21850523-6	2011	Cell-permeable iron chelators and CYP2E1 inhibitors significantly inhibited the oxidation of C11-BODIPY(581/591) in E47 cells in the presence of NaHS.	Iron	15-19	aldo-keto reductase family 1 member C4	Homo sapiens	93-96
22153517-9	2011	Hepcidin is a homeostatic regulator of iron metabolism that restricts intestinal iron absorption and is also known as a mediator of inflammation.	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	0-8
22153517-9	2011	Hepcidin is a homeostatic regulator of iron metabolism that restricts intestinal iron absorption and is also known as a mediator of inflammation.	Iron	81-85	hepcidin antimicrobial peptide	Mus musculus	0-8
22153517-10	2011	Increased serum amyloid A levels and a higher ratio of hepatic hepcidin mRNA expression to nonheme iron suggest that lower hepatic iron status in obese animals might be associated with inflammation.	Iron	131-135	hepcidin antimicrobial peptide	Mus musculus	63-71
22020364-6	2011	In addition, our results show that MCF-7/DOX cells are capable of producing higher levels of porphyrins than MCF-7/WT cells due to low expression of the enzyme ferrochelatase, which inserts iron into the tetra-pyrrol ring to form the end product heme.	Iron	190-194	ferrochelatase	Homo sapiens	160-174
22006328-4	2011	Both the WT and ADHR mice receiving low-iron diet had significantly elevated bone Fgf23 mRNA.	Iron	40-44	fibroblast growth factor 23	Mus musculus	82-87
22006328-6	2011	In contrast, the ADHR mice on the low-iron diet had elevated intact and C-terminal Fgf23 with hypophosphatemic osteomalacia.	Iron	38-42	fibroblast growth factor 23	Mus musculus	83-88
22006328-7	2011	We used in vitro iron chelation to isolate the effects of iron deficiency on Fgf23 expression.	Iron	17-21	fibroblast growth factor 23	Mus musculus	77-82
22006328-8	2011	We found that iron chelation in vitro resulted in a significant increase in Fgf23 mRNA that was dependent upon Mapk.	Iron	14-18	fibroblast growth factor 23	Mus musculus	76-81
21945528-3	2011	We were able to experimentally confirm a role of Fdx1 in the iron-sulfur cluster biosynthesis by in vitro reduction studies with cluster-loaded So ce56 IscU and by transfer studies of the cluster from the latter protein to apo-aconitase A.	Iron	61-65	ferredoxin 1	Homo sapiens	49-53
21925516-8	2011	SIGNIFICANCE: Cholestasis-induced increase in plasma and decrease in hepatic iron levels were associated with up-regulation of liver HO-1 and ferroportin 1.	Iron	77-81	heme oxygenase 1	Rattus norvegicus	133-137
21917924-6	2011	CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of either CCC1 or YAP5 resulted in high iron sensitivity.	Iron	111-115	Ccc1p	Saccharomyces cerevisiae S288C	0-4
21917924-6	2011	CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of either CCC1 or YAP5 resulted in high iron sensitivity.	Iron	111-115	Ccc1p	Saccharomyces cerevisiae S288C	81-85
21420718-3	2011	In the present study, we analyzed and compared the immunohistochemical expression of neutrophil gelatinase-associated lipocalin, an iron-binding protein, which is involved in colorectal cancer progression, in series a of 29 surgically resected colorectal carcinomas obtained from patients who died of the disease and in a cohort of 22 colorectal cancers from patients alive 5 years after the initial diagnosis.	Iron	132-136	lipocalin 2	Homo sapiens	85-127
21302291-7	2011	Increasing HIF-1alpha expression by treating PC 12 cells with the iron chelator deferoxamine for 20 h or by transfecting them with HIF-1alpha expression vector increased Nox2 expression and enzyme activity.	Iron	66-70	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	11-21
21880793-0	2011	Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans.	Iron	0-4	fibroblast growth factor 23	Homo sapiens	21-26
21880793-4	2011	OBJECTIVE: Studies were performed to test the hypothesis that plasma C-terminal and intact FGF23 concentrations are related to serum iron concentrations in ADHR.	Iron	133-137	fibroblast growth factor 23	Homo sapiens	91-96
21880793-7	2011	MAIN OUTCOME MEASURE: The relationships of serum iron concentrations with plasma C-terminal and intact FGF23 concentrations were evaluated.	Iron	49-53	fibroblast growth factor 23	Homo sapiens	103-108
21880793-9	2011	Serum iron was negatively correlated to both C-terminal FGF23 (r = -0.386; P &lt; 0.05) and intact FGF23 (r = -0.602; P &lt; 0.0001) in ADHR.	Iron	6-10	fibroblast growth factor 23	Homo sapiens	56-61
21880793-9	2011	Serum iron was negatively correlated to both C-terminal FGF23 (r = -0.386; P &lt; 0.05) and intact FGF23 (r = -0.602; P &lt; 0.0001) in ADHR.	Iron	6-10	fibroblast growth factor 23	Homo sapiens	99-104
21880793-10	2011	However, control subjects also demonstrated a negative relationship of serum iron with C-terminal FGF23 (r = -0.276; P &lt; 0.001) but no relationship with intact FGF23.	Iron	77-81	fibroblast growth factor 23	Homo sapiens	98-103
21880793-11	2011	Longitudinally in ADHR subjects, C-terminal FGF23 and intact FGF23 concentrations changed negatively with iron concentrations (P &lt; 0.001 and P = 0.055, respectively), serum phosphate changed negatively with C-terminal FGF23 and intact FGF23 (P &lt; 0.001), and there was a positive relationship between serum iron and phosphate (P &lt; 0.001).	Iron	106-110	fibroblast growth factor 23	Homo sapiens	61-66
21880793-11	2011	Longitudinally in ADHR subjects, C-terminal FGF23 and intact FGF23 concentrations changed negatively with iron concentrations (P &lt; 0.001 and P = 0.055, respectively), serum phosphate changed negatively with C-terminal FGF23 and intact FGF23 (P &lt; 0.001), and there was a positive relationship between serum iron and phosphate (P &lt; 0.001).	Iron	106-110	fibroblast growth factor 23	Homo sapiens	61-66
21880793-11	2011	Longitudinally in ADHR subjects, C-terminal FGF23 and intact FGF23 concentrations changed negatively with iron concentrations (P &lt; 0.001 and P = 0.055, respectively), serum phosphate changed negatively with C-terminal FGF23 and intact FGF23 (P &lt; 0.001), and there was a positive relationship between serum iron and phosphate (P &lt; 0.001).	Iron	106-110	fibroblast growth factor 23	Homo sapiens	61-66
22020773-2	2011	Mutations in the iron responsive element (IRE) within the 5" untranslated region of the L-ferritin (FTL) gene lead to constitutive L-ferritin synthesis resulting in hyperferritinemia.	Iron	17-21	ferritin light chain	Homo sapiens	100-103
21523820-7	2011	These iron-retaining cells exhibited high expression of a biological marker of slowly cycling cells, JARID1B.	Iron	6-10	lysine (K)-specific demethylase 5B	Mus musculus	101-108
21865291-10	2011	In addition, PCB 126-induced changes in hepatic copper, iron, manganese, and zinc were observed.	Iron	56-60	pyruvate carboxylase	Rattus norvegicus	13-16
22639604-1	2011	We demonstrate that the unique green algal iron assimilatory protein, FEA1, is able to complement the Arabidopsis iron-transporter mutant, irt1, as well as enhance iron accumulation in FEA1 expressing wild-type plants.	Iron	43-47	iron-regulated transporter 1	Arabidopsis thaliana	139-143
22639604-1	2011	We demonstrate that the unique green algal iron assimilatory protein, FEA1, is able to complement the Arabidopsis iron-transporter mutant, irt1, as well as enhance iron accumulation in FEA1 expressing wild-type plants.	Iron	114-118	iron-regulated transporter 1	Arabidopsis thaliana	139-143
21981780-0	2011	Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation.	Iron	121-125	chromosome 19 open reading frame 12	Homo sapiens	44-52
21802403-1	2011	Hephaestin is a multicopper ferroxidase involved in iron absorption in the small intestine.	Iron	52-56	hephaestin	Homo sapiens	0-10
21802403-2	2011	Expressed mainly on the basolateral surface of duodenal enterocytes, hephaestin facilitates the export of iron from the intestinal epithelium into blood by oxidizing Fe(2+) into Fe(3+), the only form of iron bound by the plasma protein transferrin.	Iron	106-110	hephaestin	Homo sapiens	69-79
21802403-2	2011	Expressed mainly on the basolateral surface of duodenal enterocytes, hephaestin facilitates the export of iron from the intestinal epithelium into blood by oxidizing Fe(2+) into Fe(3+), the only form of iron bound by the plasma protein transferrin.	Iron	203-207	hephaestin	Homo sapiens	69-79
21683107-1	2011	Lipocalin 2 (LCN2) is produced by mammalian hosts to bind bacterial siderophore and sequester free iron as part of an innate immune response, and could also play a role in tissue iron homeostasis, but thus far, little is known about its expression in the CNS.	Iron	99-103	lipocalin 2	Homo sapiens	0-11
21683107-1	2011	Lipocalin 2 (LCN2) is produced by mammalian hosts to bind bacterial siderophore and sequester free iron as part of an innate immune response, and could also play a role in tissue iron homeostasis, but thus far, little is known about its expression in the CNS.	Iron	99-103	lipocalin 2	Homo sapiens	13-17
21683107-1	2011	Lipocalin 2 (LCN2) is produced by mammalian hosts to bind bacterial siderophore and sequester free iron as part of an innate immune response, and could also play a role in tissue iron homeostasis, but thus far, little is known about its expression in the CNS.	Iron	179-183	lipocalin 2	Homo sapiens	0-11
21683107-1	2011	Lipocalin 2 (LCN2) is produced by mammalian hosts to bind bacterial siderophore and sequester free iron as part of an innate immune response, and could also play a role in tissue iron homeostasis, but thus far, little is known about its expression in the CNS.	Iron	179-183	lipocalin 2	Homo sapiens	13-17
21907140-0	2011	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.	Iron	46-50	iron responsive element binding protein 2	Mus musculus	10-14
21907140-1	2011	Iron-dependent degradation of iron-regulatory protein 2 (IRP2) is a key event for maintenance of an appropriate intracellular concentration of iron.	Iron	0-4	iron responsive element binding protein 2	Mus musculus	30-55
21907140-1	2011	Iron-dependent degradation of iron-regulatory protein 2 (IRP2) is a key event for maintenance of an appropriate intracellular concentration of iron.	Iron	0-4	iron responsive element binding protein 2	Mus musculus	57-61
21907140-1	2011	Iron-dependent degradation of iron-regulatory protein 2 (IRP2) is a key event for maintenance of an appropriate intracellular concentration of iron.	Iron	30-34	iron responsive element binding protein 2	Mus musculus	57-61
21956739-12	2011	Most significantly, predicted iron-binding motif in hABH1 was found as His231-X-Asp233-XnHis287 which corresponds to His131-XAsp133-Xn-His187 in AlkB of E. coli homologue.	Iron	30-34	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	52-57
21956739-12	2011	Most significantly, predicted iron-binding motif in hABH1 was found as His231-X-Asp233-XnHis287 which corresponds to His131-XAsp133-Xn-His187 in AlkB of E. coli homologue.	Iron	30-34	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	145-149
21704380-10	2011	Thus, in fish if IL-6 is induced in patrolling macrophages during sepsis this may act to reduce iron availability by induction of hepcidin expression and lead to iron deficiency, as a means to limit the spread of infection.	Iron	96-100	interleukin-6	Oncorhynchus mykiss	17-21
21501687-2	2011	Dcytb has been linked to uptake of dietary iron and to ascorbate recycling in erythrocytes.	Iron	43-47	cytochrome b reductase 1	Homo sapiens	0-5
21700387-9	2011	We observed complete reduction of DNAN to 2,4-diaminoanisole (DAAN) and RDX to formaldehyde in abiotic iron reduction study.	Iron	103-107	radixin	Homo sapiens	72-75
21793487-3	2011	Increasing the size of the B10 side chain reduces bimolecular rates of ligand binding nearly 5000-fold and inhibits CO geminate recombination due to both reduction of the capture volume in the distal pocket and direct steric hindrance of Fe-ligand bond formation.	Iron	238-240	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	27-30
21628566-0	2011	Monoubiquitin-dependent endocytosis of the iron-regulated transporter 1 (IRT1) transporter controls iron uptake in plants.	Iron	43-47	iron-regulated transporter 1	Arabidopsis thaliana	73-77
21628566-1	2011	Plants take up iron from the soil using the iron-regulated transporter 1 (IRT1) high-affinity iron transporter at the root surface.	Iron	15-19	iron-regulated transporter 1	Arabidopsis thaliana	44-72
21628566-1	2011	Plants take up iron from the soil using the iron-regulated transporter 1 (IRT1) high-affinity iron transporter at the root surface.	Iron	15-19	iron-regulated transporter 1	Arabidopsis thaliana	74-78
21628566-2	2011	Sophisticated regulatory mechanisms allow plants to tightly control the levels of IRT1, ensuring optimal absorption of essential but toxic iron.	Iron	139-143	iron-regulated transporter 1	Arabidopsis thaliana	82-86
21628566-5	2011	Using pharmacological approaches, we show that IRT1 cycles to the plasma membrane to perform iron and metal uptake at the cell surface and is sent to the vacuole for proper turnover.	Iron	93-97	iron-regulated transporter 1	Arabidopsis thaliana	47-51
21628566-7	2011	Together, these data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 low to ensure proper iron uptake and to prevent metal toxicity.	Iron	166-170	iron-regulated transporter 1	Arabidopsis thaliana	140-144
21902353-2	2011	The spin mixing conductance was determined by comparing the Gilbert damping in bare YIG films with those covered by a Au/Fe/Au structure.	Iron	121-123	spindlin 1	Homo sapiens	4-8
21902353-3	2011	The Fe layer in Au/Fe/Au acted as a spin sink as displayed by an increased Gilbert damping parameter alpha compared to that in the bare YIG.	Iron	4-6	spindlin 1	Homo sapiens	36-40
21902353-3	2011	The Fe layer in Au/Fe/Au acted as a spin sink as displayed by an increased Gilbert damping parameter alpha compared to that in the bare YIG.	Iron	19-21	spindlin 1	Homo sapiens	36-40
21413929-5	2011	Further secretory IL-10 level was significantly increased (P&lt;0.001) or decreased (P&lt;0.001) in response to iron supplementation [FAC (ferric ammonium citrate)] and depletion [DFO (deferoxamine)], respectively.	Iron	112-116	interleukin 10	Homo sapiens	18-23
21628413-1	2011	Hepcidin is an antimicrobial peptide that controls systemic iron homeostasis.	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	0-8
21628413-2	2011	Hepcidin binding to its receptor ferroportin reduces iron availability, thus controlling microbial growth.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	0-8
21628413-4	2011	Hepcidin is transcriptionally regulated by iron, through the bone morphogenetic protein-son of mothers against decapentaplegic (BMP-SMAD) pathway and by inflammation, through IL6-mediated STAT3 signaling.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	0-8
21436314-7	2011	The results showed that expression of hepatic hepcidin was significantly decreased and intestinal Hif2alpha was significantly increased in b/b and iron-fed b/b than +/+ rats.	Iron	147-151	endothelial PAS domain protein 1	Rattus norvegicus	98-107
21436314-10	2011	Thus in b/b rats depressed liver hepcidin production and activated intestinal Hif2alpha starting at the C-pole resulted in increasing expression of iron transport genes, including DMT1 G185R, in an attempt to compensate for the anemia in Belgrade rats.	Iron	148-152	endothelial PAS domain protein 1	Rattus norvegicus	78-87
21627978-3	2011	The major focus was mitoferrin-1 (MFRN1), the mitochondrial transporter of Fe used for heme formation by FECH and for 2Fe2S cluster synthesis, which is critical to FECH activity/stability.	Iron	75-77	solute carrier family 25 member 37	Homo sapiens	20-32
21627978-3	2011	The major focus was mitoferrin-1 (MFRN1), the mitochondrial transporter of Fe used for heme formation by FECH and for 2Fe2S cluster synthesis, which is critical to FECH activity/stability.	Iron	75-77	solute carrier family 25 member 37	Homo sapiens	34-39
21627978-3	2011	The major focus was mitoferrin-1 (MFRN1), the mitochondrial transporter of Fe used for heme formation by FECH and for 2Fe2S cluster synthesis, which is critical to FECH activity/stability.	Iron	75-77	ferrochelatase	Homo sapiens	105-109
21627978-3	2011	The major focus was mitoferrin-1 (MFRN1), the mitochondrial transporter of Fe used for heme formation by FECH and for 2Fe2S cluster synthesis, which is critical to FECH activity/stability.	Iron	75-77	ferrochelatase	Homo sapiens	164-168
24250389-2	2011	In contrast to the chemical iron chelators, there has been limited effort applied to the specific use of hepcidin as a new drug for decreasing the iron overload.	Iron	147-151	hepcidin antimicrobial peptide	Mus musculus	105-113
24250389-11	2011	Functional tests showed that mouse hepcidin accumulates iron in the macrophage cell line J774A.1 up to 63%.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	35-43
21542867-1	2011	Saccharomyces cerevisiae can import iron through a high-affinity system consisting of the Ftr1/Fet3-mediated reductive pathway and the siderophore-mediated non-reductive one.	Iron	36-40	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	90-94
21542867-9	2011	This reinforces the idea that upon oxidative stress S. cerevisiae cells redirect iron assimilation through the non-reductive pathway to minimize oxidative damage by the ferrous ions, which are formed during iron import through the Ftr1/Fet3 complexes.	Iron	81-85	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	231-235
21542867-9	2011	This reinforces the idea that upon oxidative stress S. cerevisiae cells redirect iron assimilation through the non-reductive pathway to minimize oxidative damage by the ferrous ions, which are formed during iron import through the Ftr1/Fet3 complexes.	Iron	207-211	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	231-235
21706009-4	2011	Here we show experimental evidence that spin pumping enables spin injection free from this condition; room-temperature spin injection into GaAs from Ni(81)Fe(19) through an Ohmic contact is demonstrated through dynamical spin exchange.	Iron	155-157	spindlin 1	Homo sapiens	40-44
20018301-3	2011	The inducible heme oxygenase-1 (HO-1) catalyzes the stepwise degradation of heme to produce equimolar quantities of biliverdin, iron, and carbon monoxide; it has also been suggested to promote the important cholesterol-independent cytoprotective action of statins against oxidative insults.	Iron	128-132	heme oxygenase 1	Rattus norvegicus	14-30
20018301-3	2011	The inducible heme oxygenase-1 (HO-1) catalyzes the stepwise degradation of heme to produce equimolar quantities of biliverdin, iron, and carbon monoxide; it has also been suggested to promote the important cholesterol-independent cytoprotective action of statins against oxidative insults.	Iron	128-132	heme oxygenase 1	Rattus norvegicus	32-36
21303570-4	2011	Hepcidin injection inhibited Fe absorption in both genotypes, but the effects were more evident in the knockout mice.	Iron	29-31	hepcidin antimicrobial peptide	Mus musculus	0-8
21303570-8	2011	The present study demonstrates that hepcidin deficiency causes increased Fe absorption.	Iron	73-75	hepcidin antimicrobial peptide	Mus musculus	36-44
21303570-9	2011	The effects of hepcidin were abolished by dietary Fe deficiency, indicating that the response to hepcidin may be influenced by dietary Fe level or Fe status.	Iron	50-52	hepcidin antimicrobial peptide	Mus musculus	97-105
21303570-9	2011	The effects of hepcidin were abolished by dietary Fe deficiency, indicating that the response to hepcidin may be influenced by dietary Fe level or Fe status.	Iron	135-137	hepcidin antimicrobial peptide	Mus musculus	15-23
21303570-9	2011	The effects of hepcidin were abolished by dietary Fe deficiency, indicating that the response to hepcidin may be influenced by dietary Fe level or Fe status.	Iron	135-137	hepcidin antimicrobial peptide	Mus musculus	97-105
21469227-6	2011	Furthermore, the axial ligand of the oxidant influences the pK(a) value of the iron(IV)-oxo group, and, as a consequence, the bond dissociation energy (BDE(OH) value correlates with the barrier height for the reverse sulfoxidation reaction.	Iron	79-83	homeobox D13	Homo sapiens	152-155
21454570-5	2011	Moreover, the Tyr to Cys mutation cross-links together the cytochrome b and iron-sulfur subunits and renders the bacterial enzyme sensitive to O(2) by oxidative disruption of its catalytic [2Fe-2S] cluster.	Iron	76-80	mitochondrially encoded cytochrome b	Homo sapiens	59-71
21520181-0	2011	The hepcidin circuits act: balancing iron and inflammation.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	4-12
21520181-1	2011	Hepcidin is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide.	Iron	45-49	hepcidin antimicrobial peptide	Mus musculus	0-8
21520181-3	2011	Hepcidin mediates iron homeostasis by binding to the iron exporter ferroportin, inducing its internalization and degradation via activation of the protein kinase Jak2 and the subsequent phosphorylation of ferroportin.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	0-8
21520181-3	2011	Hepcidin mediates iron homeostasis by binding to the iron exporter ferroportin, inducing its internalization and degradation via activation of the protein kinase Jak2 and the subsequent phosphorylation of ferroportin.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	0-8
21498596-2	2011	Iron is used in the formation of both hemoglobin and myoglobin, as well as numerous enzyme systems of the body.	Iron	0-4	myoglobin	Canis lupus familiaris	53-62
21385868-8	2011	Genes of the Aft1p-dependent iron regulon were induced specifically in the absence of Prx1p despite optimal mitochondrial Fe-S biogenesis, suggesting dysfunction of the mitochondria to the cytosol signaling pathway.	Iron	29-33	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	13-18
21385868-8	2011	Genes of the Aft1p-dependent iron regulon were induced specifically in the absence of Prx1p despite optimal mitochondrial Fe-S biogenesis, suggesting dysfunction of the mitochondria to the cytosol signaling pathway.	Iron	122-126	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	13-18
21296883-7	2011	Iron chelation decreased basal synaptic transmission in hippocampal slices, inhibited iron-induced synaptic stimulation, and impaired sustained LTP in hippocampal CA1 neurons induced by strong stimulation.	Iron	0-4	carbonic anhydrase 1	Homo sapiens	163-166
21296142-8	2011	Systemic S/B remedy attenuated the iron-induced increases in heme-oxygenase-1 levels and alpha-synuclein aggregation in the infused SN.	Iron	35-39	heme oxygenase 1	Rattus norvegicus	61-77
21296142-8	2011	Systemic S/B remedy attenuated the iron-induced increases in heme-oxygenase-1 levels and alpha-synuclein aggregation in the infused SN.	Iron	35-39	synuclein alpha	Rattus norvegicus	89-104
21361388-0	2011	Biophysical investigation of the iron in Aft1-1(up) and Gal-YAH1 Saccharomyces cerevisiae.	Iron	33-37	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	41-45
21361388-1	2011	Aft1p is a major iron regulator in budding yeast Saccharomyces cerevisiae.	Iron	17-21	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
21361388-3	2011	Aft1p within the Aft1-1(up) strain has a single amino acid mutation which causes it to constitutively activate iron regulon genes regardless of cellular Fe status.	Iron	111-115	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
21361388-3	2011	Aft1p within the Aft1-1(up) strain has a single amino acid mutation which causes it to constitutively activate iron regulon genes regardless of cellular Fe status.	Iron	111-115	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
21361388-3	2011	Aft1p within the Aft1-1(up) strain has a single amino acid mutation which causes it to constitutively activate iron regulon genes regardless of cellular Fe status.	Iron	153-155	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
21361388-3	2011	Aft1p within the Aft1-1(up) strain has a single amino acid mutation which causes it to constitutively activate iron regulon genes regardless of cellular Fe status.	Iron	153-155	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
21361388-5	2011	Ferredoxin Yah1p is involved in Fe/S cluster assembly, and Aft1p-targeted iron regulon genes are also upregulated in Yah1p-depleted cells.	Iron	74-78	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	59-64
21361388-6	2011	In this study Mossbauer, EPR, and UV-vis spectroscopies were used to characterize the Fe distribution in Aft1-1(up) and Yah1p-depleted cells.	Iron	86-88	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	105-109
21361388-7	2011	Aft1-1(up) cells grown in low Fe medium contained more Fe than did WT cells.	Iron	30-32	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
21361388-8	2011	A basal level of Fe in both WT and Aft1-1(up) cells was located in mitochondria, primarily in the form of Fe/S clusters and heme centers.	Iron	17-19	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	35-39
21361388-8	2011	A basal level of Fe in both WT and Aft1-1(up) cells was located in mitochondria, primarily in the form of Fe/S clusters and heme centers.	Iron	106-108	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	35-39
21361388-11	2011	Aft1-1(up) cells grown in high Fe medium contained far more Fe than found in WT cells.	Iron	31-33	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
21361388-11	2011	Aft1-1(up) cells grown in high Fe medium contained far more Fe than found in WT cells.	Iron	60-62	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
21278260-1	2011	Divalent metal transporter 1 (DMT1) is the major iron transporter responsible for duodenal dietary iron absorption and is required for erythropoiesis.	Iron	49-53	RoBo-1	Rattus norvegicus	0-28
21278260-1	2011	Divalent metal transporter 1 (DMT1) is the major iron transporter responsible for duodenal dietary iron absorption and is required for erythropoiesis.	Iron	49-53	RoBo-1	Rattus norvegicus	30-34
21303654-6	2011	Previous studies showed that inflammatory stimuli, such as LPS, downregulates macrophage Fpn1 by transcriptional and hepcidin-mediated post-translational mechanisms leading to iron sequestration by macrophages.	Iron	176-180	hepcidin antimicrobial peptide	Mus musculus	117-125
21029774-5	2011	We show here the facile assembly of Mt-FTL and FTH1 subunits into soluble ferritin heteropolymers, but their ability to incorporate iron was significantly reduced relative to Wt-FTL/FTH1 heteropolymers.	Iron	132-136	ferritin light chain	Homo sapiens	39-42
21480335-0	2011	Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.	Iron	75-79	hepcidin antimicrobial peptide	Mus musculus	34-42
21480335-1	2011	UNLABELLED: In response to iron loading, hepcidin synthesis is homeostatically increased to limit further absorption of dietary iron and its release from stores.	Iron	27-31	hepcidin antimicrobial peptide	Mus musculus	41-49
21480335-1	2011	UNLABELLED: In response to iron loading, hepcidin synthesis is homeostatically increased to limit further absorption of dietary iron and its release from stores.	Iron	128-132	hepcidin antimicrobial peptide	Mus musculus	41-49
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	homeostatic iron regulator	Mus musculus	13-16
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	transferrin receptor 2	Mus musculus	18-40
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	transferrin receptor 2	Mus musculus	42-46
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	hemojuvelin BMP co-receptor	Mus musculus	49-60
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	hemojuvelin BMP co-receptor	Mus musculus	62-65
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	148-152	hepcidin antimicrobial peptide	Mus musculus	127-135
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	homeostatic iron regulator	Mus musculus	13-16
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	transferrin receptor 2	Mus musculus	18-40
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	hemojuvelin BMP co-receptor	Mus musculus	49-60
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	hemojuvelin BMP co-receptor	Mus musculus	62-65
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	hepcidin antimicrobial peptide	Mus musculus	127-135
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	homeostatic iron regulator	Mus musculus	13-16
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	transferrin receptor 2	Mus musculus	18-40
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	hemojuvelin BMP co-receptor	Mus musculus	49-60
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	hemojuvelin BMP co-receptor	Mus musculus	62-65
21480335-2	2011	Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload.	Iron	195-199	hepcidin antimicrobial peptide	Mus musculus	127-135
21480335-3	2011	To understand the role each of these proteins plays in hepcidin regulation by iron, we analyzed hepcidin messenger RNA (mRNA) responsiveness to short and long-term iron challenge in iron-depleted Hfe, Tfr2, Hjv, and Bmp6 mutant mice.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	55-63
21480335-3	2011	To understand the role each of these proteins plays in hepcidin regulation by iron, we analyzed hepcidin messenger RNA (mRNA) responsiveness to short and long-term iron challenge in iron-depleted Hfe, Tfr2, Hjv, and Bmp6 mutant mice.	Iron	164-168	hepcidin antimicrobial peptide	Mus musculus	96-104
21480335-3	2011	To understand the role each of these proteins plays in hepcidin regulation by iron, we analyzed hepcidin messenger RNA (mRNA) responsiveness to short and long-term iron challenge in iron-depleted Hfe, Tfr2, Hjv, and Bmp6 mutant mice.	Iron	164-168	hepcidin antimicrobial peptide	Mus musculus	96-104
21480335-4	2011	After 1-day (acute) iron challenge, Hfe(-/-) mice showed a smaller hepcidin increase than their wild-type strain-matched controls, Bmp6(-/-) mice showed nearly no increase, and Tfr2 and Hjv mutant mice showed no increase in hepcidin expression, indicating that all four proteins participate in hepcidin regulation by acute iron changes.	Iron	20-24	homeostatic iron regulator	Mus musculus	36-39
21480335-4	2011	After 1-day (acute) iron challenge, Hfe(-/-) mice showed a smaller hepcidin increase than their wild-type strain-matched controls, Bmp6(-/-) mice showed nearly no increase, and Tfr2 and Hjv mutant mice showed no increase in hepcidin expression, indicating that all four proteins participate in hepcidin regulation by acute iron changes.	Iron	20-24	hepcidin antimicrobial peptide	Mus musculus	67-75
21364282-1	2011	Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	101-109
21364282-1	2011	Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release.	Iron	9-13	hepcidin antimicrobial peptide	Mus musculus	122-126
21364282-1	2011	Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Mus musculus	101-109
21364282-1	2011	Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Mus musculus	122-126
21364282-1	2011	Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Mus musculus	101-109
21364282-1	2011	Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release.	Iron	159-163	hepcidin antimicrobial peptide	Mus musculus	122-126
21364282-4	2011	Moreover, miR-122 inhibition increased the amount of mRNA transcribed by genes that control systemic iron levels, such as hemochromatosis (Hfe), hemojuvelin (Hjv), bone morphogenetic protein receptor type 1A (Bmpr1a), and Hamp.	Iron	101-105	homeostatic iron regulator	Mus musculus	139-142
20971194-8	2011	The neogenin FN5-6 structure can be used to facilitate a molecular understanding of neogenin"s interaction with hemojuvelin to regulate iron homeostasis and with hemojuvelin-related repulsive guidance molecules to mediate axon guidance.	Iron	136-140	single-pass membrane protein with coiled-coil domains 4	Homo sapiens	13-18
20971194-8	2011	The neogenin FN5-6 structure can be used to facilitate a molecular understanding of neogenin"s interaction with hemojuvelin to regulate iron homeostasis and with hemojuvelin-related repulsive guidance molecules to mediate axon guidance.	Iron	136-140	neogenin 1	Homo sapiens	84-92
21219335-4	2011	Arabidopsis halleri shows low expression of the Fe acquisition and deficiency response-related genes IRT1 and IRT2 compared with A. thaliana.	Iron	48-50	iron-regulated transporter 1	Arabidopsis thaliana	101-105
21219335-5	2011	In A. thaliana, lowering the expression of IRT1 and IRT2 through the addition of excess Fe to the medium increases Zn tolerance.	Iron	88-90	iron-regulated transporter 1	Arabidopsis thaliana	43-47
21219335-9	2011	Overexpressing a ZIP family member IRT3 in irt1-1, rescues the Fe-deficient phenotype.	Iron	63-65	iron-regulated transporter 1	Arabidopsis thaliana	43-47
21469904-1	2011	Using density functional theory plus Hubbard U calculations, we show that the ground state of (Mg,Fe)(Si,Fe)O(3) perovskite, the major mineral phase in Earth"s lower mantle, has high-spin ferric iron (S=5/2) at both dodecahedral (A) and octahedral (B) sites.	Iron	98-100	spindlin 1	Homo sapiens	183-187
21469904-2	2011	With increasing pressure, the B-site iron undergoes a spin-state crossover to the low-spin state (S=1/2) between 40 and 70 GPa, while the A-site iron remains in the high-spin state.	Iron	37-41	spindlin 1	Homo sapiens	54-58
21469904-2	2011	With increasing pressure, the B-site iron undergoes a spin-state crossover to the low-spin state (S=1/2) between 40 and 70 GPa, while the A-site iron remains in the high-spin state.	Iron	37-41	spindlin 1	Homo sapiens	86-90
21469904-2	2011	With increasing pressure, the B-site iron undergoes a spin-state crossover to the low-spin state (S=1/2) between 40 and 70 GPa, while the A-site iron remains in the high-spin state.	Iron	37-41	spindlin 1	Homo sapiens	86-90
21346125-0	2011	Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase.	Iron	0-4	Malvolio	Drosophila melanogaster	36-44
21346125-6	2011	Iron supplementation restored total body iron concentrations in Mvl mutants, but without replenishing iron stores in the middle midgut, suggesting a role for Mvl in systemic iron trafficking, in addition to a role in intestinal iron absorption.	Iron	0-4	Malvolio	Drosophila melanogaster	64-67
21346125-6	2011	Iron supplementation restored total body iron concentrations in Mvl mutants, but without replenishing iron stores in the middle midgut, suggesting a role for Mvl in systemic iron trafficking, in addition to a role in intestinal iron absorption.	Iron	0-4	Malvolio	Drosophila melanogaster	158-161
21346125-8	2011	We investigated whether dietary copper affected iron storage through the function of an insect multicopper oxidase (MCO), because the mammalian MCO ceruloplasmin is known to regulate iron storage in the liver.	Iron	183-187	Multicopper oxidase 3	Drosophila melanogaster	95-114
21346125-8	2011	We investigated whether dietary copper affected iron storage through the function of an insect multicopper oxidase (MCO), because the mammalian MCO ceruloplasmin is known to regulate iron storage in the liver.	Iron	183-187	Multicopper oxidase 3	Drosophila melanogaster	116-119
21346125-9	2011	We identified a Drosophila MCO mutant that suppressed aspects of the Mvl mutant phenotype and most notably Mvl, MCO3 double mutants showed normal intestinal iron storage.	Iron	157-161	Multicopper oxidase 3	Drosophila melanogaster	27-30
21346125-9	2011	We identified a Drosophila MCO mutant that suppressed aspects of the Mvl mutant phenotype and most notably Mvl, MCO3 double mutants showed normal intestinal iron storage.	Iron	157-161	Multicopper oxidase 3	Drosophila melanogaster	112-116
21222436-1	2011	The heme biosynthetic pathway culminates with the ferrochelatase-catalyzed ferrous iron chelation into protoporphyrin IX to form protoheme.	Iron	75-87	ferrochelatase	Mus musculus	50-64
21271699-2	2011	As the spin crossover between the low-spin (LS) and high-spin (HS) states can occur only for two of four iron ions, we characterized energetically and structurally the [LS-LS], [HS-LS], and [HS-HS] spin-state isomers.	Iron	105-109	spindlin 1	Homo sapiens	7-11
21181420-9	2011	These results suggest that the existence of various forms of iron is an important contributing factor to the elevated nitrative/oxidative modifications and diminished activity of alpha-enolase in the development and progress of iron-overload-associated syndromes.	Iron	61-65	enolase 1	Rattus norvegicus	179-192
21181420-9	2011	These results suggest that the existence of various forms of iron is an important contributing factor to the elevated nitrative/oxidative modifications and diminished activity of alpha-enolase in the development and progress of iron-overload-associated syndromes.	Iron	228-232	enolase 1	Rattus norvegicus	179-192
21421125-9	2011	We hypothesized that the inhibitory mechanism of PHD3 activity by polynitrogen compounds is due to their binding to iron to form stable coordination complexes.	Iron	116-120	egl-9 family hypoxia inducible factor 3	Homo sapiens	49-53
21211566-7	2011	In the P16 rat, the uptake of (59)Fe expressed as the volume of distribution, V(D), rose linearly reaching approximately 2500 nl at 60 min.	Iron	34-36	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	7-10
20696680-7	2011	Five days after the IV administration of 200 mg iron sucrose, a significant increase of RTC was observed, only in those patients with elevated baseline CRP levels who also showed an increase in CHr levels from &lt;= 31.2 pg at baseline to &gt;= 31.2 pg post-administration, supporting the presence of an independent positive correlation between CRP and RTC when iron is adequate.	Iron	48-52	chromate resistance; sulfate transport	Homo sapiens	194-197
21705982-4	2011	Chronic anemia, iron toxicity and endocrine complications, via a complex mechanism, lead to alterations in the RANK/RANKL/OPG system in favor of increased osteoclastic activity and enhanced osteoblastic dysfunction.	Iron	16-20	TNF superfamily member 11	Homo sapiens	116-121
21705982-4	2011	Chronic anemia, iron toxicity and endocrine complications, via a complex mechanism, lead to alterations in the RANK/RANKL/OPG system in favor of increased osteoclastic activity and enhanced osteoblastic dysfunction.	Iron	16-20	basic transcription factor 3 pseudogene 11	Homo sapiens	122-125
20686796-1	2011	BACKGROUND: Heme oxygenase-1 (HO-1), the rate-limiting enzyme for heme catabolism and iron production, its role in intracerebral hemorrhage (ICH) is controversial.	Iron	86-90	heme oxygenase 1	Rattus norvegicus	12-28
20686796-1	2011	BACKGROUND: Heme oxygenase-1 (HO-1), the rate-limiting enzyme for heme catabolism and iron production, its role in intracerebral hemorrhage (ICH) is controversial.	Iron	86-90	heme oxygenase 1	Rattus norvegicus	30-34
20015204-3	2011	We suggested that following receptor mediated endocytosis of transferrin filtered by the glomerulus, DMT1 exports iron liberated from transferrin into the cytosol.	Iron	114-118	RoBo-1	Rattus norvegicus	101-105
21176945-8	2011	The inhibition of both methanogens and SRB was found to enhance the iron reduction rates but did not completely stop MMHg production.	Iron	68-72	chaperonin containing TCP1 subunit 4	Homo sapiens	39-42
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Iron	28-32	Bol2p	Saccharomyces cerevisiae S288C	17-21
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Iron	28-32	Bol2p	Saccharomyces cerevisiae S288C	71-75
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Iron	28-32	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	76-80
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Iron	117-121	Bol2p	Saccharomyces cerevisiae S288C	17-21
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Iron	117-121	Bol2p	Saccharomyces cerevisiae S288C	71-75
20978135-0	2011	Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.	Iron	117-121	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	76-80
20978135-1	2011	The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae.	Iron	119-123	Bol2p	Saccharomyces cerevisiae S288C	19-23
20978135-1	2011	The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae.	Iron	119-123	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	66-70
20978135-2	2011	Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis.	Iron	71-75	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	30-34
21123956-11	2011	Hypoxia mimetic iron chelator deferroxamine promoted p53 accumulation in H9c2 myoblast cells by suppressing the Akt/MDM2 pathway, which was restored by ATR.	Iron	16-20	MDM2 proto-oncogene	Rattus norvegicus	116-120
21183793-3	2011	Specifically, we demonstrated that phage clones displaying an iron-mimic peptide were able to target a protein complex of transferrin and transferrin receptor (TfR) through a non-canonical allosteric binding mechanism and that this functional protein complex mediated transport of the corresponding viral particles into the normal mouse brain.	Iron	62-66	transferrin	Mus musculus	122-133
21547258-5	2011	Anti-inflammatory cytokine levels were normal, except for Il-10, supporting previous indications that Il-10 contributes to reducing bioavailable iron.	Iron	145-149	interleukin 10	Homo sapiens	102-107
21346313-6	2011	Moreover, we demonstrated that both iron chelators were able to decrease TDP-43 protein aggregation and the proapoptotic molecule Bax, and to enhance antiapoptotic protein Bcl-2 expression, in the ALS mice.	Iron	36-40	BCL2-associated X protein	Mus musculus	130-133
22003390-0	2011	Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.	Iron	0-4	iron responsive element binding protein 2	Mus musculus	81-85
22003390-1	2011	Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis.	Iron	100-104	iron responsive element binding protein 2	Mus musculus	20-45
22003390-1	2011	Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis.	Iron	100-104	iron responsive element binding protein 2	Mus musculus	47-51
22003390-1	2011	Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis.	Iron	100-104	iron responsive element binding protein 2	Mus musculus	53-58
22003390-2	2011	Here we have demonstrated that misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy.	Iron	48-52	iron responsive element binding protein 2	Mus musculus	77-81
21957487-11	2011	Furthermore, our results demonstrated that the levels of hypoxia-inducible factor-1alpha (HIF-1alpha) were significantly higher in the cerebral cortex, hippocampus and striatum on the ischemic side; therefore, the HIF-1alpha-mediated TfR1 expression may be another contributor to the iron overload in the ischemia-reperfusion brain.	Iron	284-288	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	57-88
21957487-11	2011	Furthermore, our results demonstrated that the levels of hypoxia-inducible factor-1alpha (HIF-1alpha) were significantly higher in the cerebral cortex, hippocampus and striatum on the ischemic side; therefore, the HIF-1alpha-mediated TfR1 expression may be another contributor to the iron overload in the ischemia-reperfusion brain.	Iron	284-288	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	90-100
21957487-11	2011	Furthermore, our results demonstrated that the levels of hypoxia-inducible factor-1alpha (HIF-1alpha) were significantly higher in the cerebral cortex, hippocampus and striatum on the ischemic side; therefore, the HIF-1alpha-mediated TfR1 expression may be another contributor to the iron overload in the ischemia-reperfusion brain.	Iron	284-288	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	214-224
21886823-0	2011	Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.	Iron	0-4	ferritin heavy polypeptide 1	Mus musculus	35-45
21886823-12	2011	HFt taken up by TIM-2 positive cells transited through the endosome and eventually entered a lysosomal compartment, distinguishing the HFt pathway from that of transferrin, the classical vehicle for cellular iron delivery.	Iron	208-212	transferrin	Mus musculus	160-171
20956517-3	2010	The main conclusion unambiguously points to the up-regulation of iron transport systems as a primary effect of YFH1 down-regulation.	Iron	65-69	ferroxidase	Saccharomyces cerevisiae S288C	111-115
20956517-9	2010	In summary, the results presented here indicate that decreased iron-sulfur enzyme activities in YFH1-deficient cells are the consequence of the oxidative stress conditions suffered by these cells.	Iron	63-67	ferroxidase	Saccharomyces cerevisiae S288C	96-100
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	100-104	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	263-267
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	263-267
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	263-267
21235502-8	2010	The three members of this subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron relocalization (Grx3 and Grx4).	Iron	166-170	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	263-267
20617342-6	2010	We present a child with HHCS due to the allelic variant c.-167C&gt;T (C33T) in the iron-responsive element region of the FTL gene.	Iron	83-87	ferritin light chain	Homo sapiens	121-124
20858542-1	2010	Repulsive guidance molecule c (RGMc; gene symbol: Hfe2) plays a critical role in iron metabolism.	Iron	81-85	hemojuvelin BMP co-receptor	Mus musculus	0-29
20858542-1	2010	Repulsive guidance molecule c (RGMc; gene symbol: Hfe2) plays a critical role in iron metabolism.	Iron	81-85	hemojuvelin BMP co-receptor	Mus musculus	31-35
20858542-1	2010	Repulsive guidance molecule c (RGMc; gene symbol: Hfe2) plays a critical role in iron metabolism.	Iron	81-85	hemojuvelin BMP co-receptor	Mus musculus	50-54
21059997-9	2010	Signaling via iron-catalyzed protein oxidation mediates hypoxic pulmonary hypertension-induced annexin A1 degradation, Gata4 gene transcription, and right ventricular hypertrophy.	Iron	14-18	annexin A1	Homo sapiens	95-105
21059997-9	2010	Signaling via iron-catalyzed protein oxidation mediates hypoxic pulmonary hypertension-induced annexin A1 degradation, Gata4 gene transcription, and right ventricular hypertrophy.	Iron	14-18	GATA binding protein 4	Homo sapiens	119-124
21099112-0	2010	Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	0-8
21099112-3	2010	Iron overload is associated with low levels of hepcidin, a peptide that regulates iron metabolism by triggering degradation of ferroportin, an iron-transport protein localized on absorptive enterocytes as well as hepatocytes and macrophages.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	47-55
21099112-3	2010	Iron overload is associated with low levels of hepcidin, a peptide that regulates iron metabolism by triggering degradation of ferroportin, an iron-transport protein localized on absorptive enterocytes as well as hepatocytes and macrophages.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	47-55
21099112-6	2010	Here we demonstrate that a moderate increase in expression of hepcidin in beta-thalassemic mice limits iron overload, decreases formation of insoluble membrane-bound globins and reactive oxygen species, and improves anemia.	Iron	103-107	hepcidin antimicrobial peptide	Mus musculus	62-70
21099112-8	2010	These data led us to suggest that therapeutics that could increase hepcidin levels or act as hepcidin agonists might help treat the abnormal iron absorption in individuals with beta-thalassemia and related disorders.	Iron	141-145	hepcidin antimicrobial peptide	Mus musculus	67-75
21099112-8	2010	These data led us to suggest that therapeutics that could increase hepcidin levels or act as hepcidin agonists might help treat the abnormal iron absorption in individuals with beta-thalassemia and related disorders.	Iron	141-145	hepcidin antimicrobial peptide	Mus musculus	93-101
20813419-0	2010	Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells.	Iron	0-4	MIR7-3 host gene	Homo sapiens	72-76
21124897-9	2010	Sequestration of PIP2 by RFP-PH at higher doses resulted in changes of subplasmalemmal actin networks which significantly delayed the intracellular Ca(2+) signaling, impaired elevation of FE, and increased occurrences of polyspermic fertilization.	Iron	188-190	tripartite motif containing 27	Homo sapiens	25-28
21139976-1	2010	PURPOSE: To investigate whether acquired somatic mutations in the iron response element of the ferritin L-chain gene account for the age-related cataract.	Iron	66-70	ferritin light chain	Homo sapiens	95-111
21067605-3	2010	To gain some understanding on the molecular basis of HF, we characterized iron metabolism in primary cultures of human skin fibroblasts from an individual with the FTL c.497_498dupTC mutation.	Iron	74-78	ferritin light chain	Homo sapiens	164-167
21231194-1	2010	We report on a combined experimental and theoretical study of the spin-dependent relaxation processes in the electron system of an iron film on Cu(100).	Iron	131-135	spindlin 1	Homo sapiens	66-70
21403328-0	2010	Nucleation of hcp and fcc phases in bcc iron under uniform compression: classical molecular dynamics simulations.	Iron	40-44	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	14-17
21403328-1	2010	By classical molecular dynamics simulations employing an embedded atom method potential, we have simulated the bcc to hcp/fcc structural transition in single-crystal iron under uniform compression.	Iron	166-170	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	118-121
21403328-7	2010	We have investigated the transition mechanism of iron from initial bcc to hcp/fcc and found that the transition mainly consists of compression, rotation, and shuffle.	Iron	49-53	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	74-77
21072368-3	2010	However, the crystal structure of chicken sulfite oxidase (CSO) has shown that there is a 32 A distance between the Fe and Mo atoms of the respective heme and molybdenum domains, which are connected by a flexible polypeptide tether.	Iron	116-118	sulfite oxidase	Gallus gallus	42-57
20815377-0	2010	Molecular details of the yeast frataxin-Isu1 interaction during mitochondrial Fe-S cluster assembly.	Iron	78-82	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	40-44
20815377-3	2010	Biochemical and genetic studies have shown frataxin interacts with the iron-sulfur cluster assembly scaffold protein (in yeast, there are two, Isu1 and Isu2), indicating frataxin plays a direct role in cluster assembly, possibly by serving as an iron chaperone in the assembly pathway.	Iron	71-75	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	143-147
20815377-3	2010	Biochemical and genetic studies have shown frataxin interacts with the iron-sulfur cluster assembly scaffold protein (in yeast, there are two, Isu1 and Isu2), indicating frataxin plays a direct role in cluster assembly, possibly by serving as an iron chaperone in the assembly pathway.	Iron	71-75	putative iron-binding protein ISU2	Saccharomyces cerevisiae S288C	152-156
20815377-3	2010	Biochemical and genetic studies have shown frataxin interacts with the iron-sulfur cluster assembly scaffold protein (in yeast, there are two, Isu1 and Isu2), indicating frataxin plays a direct role in cluster assembly, possibly by serving as an iron chaperone in the assembly pathway.	Iron	246-250	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	143-147
20815377-7	2010	X-ray absorption studies were used to electronically and structurally characterize how iron is transferred to Isu1 and then incorporated into an Fe-S cluster.	Iron	87-91	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	110-114
20815377-7	2010	X-ray absorption studies were used to electronically and structurally characterize how iron is transferred to Isu1 and then incorporated into an Fe-S cluster.	Iron	145-147	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	110-114
20610401-1	2010	The feline leukemia virus subgroup C receptor (FLVCR) is a heme export protein that is required for proerythroblast survival and facilitates macrophage heme iron recycling.	Iron	157-161	FLVCR heme transporter 1	Homo sapiens	47-52
21403289-1	2010	The shock-induced bcc (body-centered cubic) to hcp (hexagonal-closed packing) transition in iron containing a nanovoid was investigated by molecular dynamics simulations with a shock-front absorbing boundary condition.	Iron	92-96	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	47-50
24431481-0	2010	RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for ATM, RAD9 and BRCA1.	Iron	32-36	BRCA1 DNA repair associated	Homo sapiens	92-97
24431481-5	2010	Our results show that cells heterozygous for both Atm and Rad9 or Atm and Brca1 have high survival rates and are more sensitive to transformation by high energy Iron ions when compared with wild-type controls or cells haploinsufficient for only one of these proteins.	Iron	161-165	BRCA1 DNA repair associated	Homo sapiens	74-79
20805566-6	2010	Interestingly, we found that a low level of duodenal divalent metal transporter 1 and ferroportin, two iron transporters located on the apical and basolateral membrane of duodenal absorptive enterocytes, respectively, correlates with abnormally high expression of hepcidin, despite the poor hepatic and overall iron status of these animals.	Iron	103-107	hepcidin antimicrobial peptide	Sus scrofa	264-272
20805566-9	2010	Here we demonstrate that a modified strategy for iron supplementation of newborn piglets with iron dextran improves the piglets" hematological status, attenuates the induction of hepcidin expression, and minimizes the toxicity of the administered iron.	Iron	49-53	hepcidin antimicrobial peptide	Sus scrofa	179-187
20805566-9	2010	Here we demonstrate that a modified strategy for iron supplementation of newborn piglets with iron dextran improves the piglets" hematological status, attenuates the induction of hepcidin expression, and minimizes the toxicity of the administered iron.	Iron	94-98	hepcidin antimicrobial peptide	Sus scrofa	179-187
20517154-8	2010	These macrophages express CD163, a scavenger receptor that binds hemoglobin-haptoglobin complexes, and initiate pathways important for adaptation to oxidative stress induced by free iron.	Iron	182-186	CD163 molecule	Homo sapiens	26-31
20805568-17	2010	Increased iron availability also increased cystine uptake and glutathione concentration and decreased nuclear translocation of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor (VEGF) accumulation in the cell-conditioned medium.	Iron	10-14	vascular endothelial growth factor A	Canis lupus familiaris	164-198
20805568-17	2010	Increased iron availability also increased cystine uptake and glutathione concentration and decreased nuclear translocation of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor (VEGF) accumulation in the cell-conditioned medium.	Iron	10-14	vascular endothelial growth factor A	Canis lupus familiaris	200-204
20429018-8	2010	The iron-responsive transcription factor Aft1p appears activated in cells with high phosphate content in spite of normal intracellular iron levels.	Iron	4-8	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	41-46
20429018-8	2010	The iron-responsive transcription factor Aft1p appears activated in cells with high phosphate content in spite of normal intracellular iron levels.	Iron	135-139	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	41-46
20429018-10	2010	Such lowering of phosphate content by pho4 mutations reversed the high calcium and sodium content of pho80 mutants and prevented the iron starvation response.	Iron	133-137	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	38-42
20627899-1	2010	In a previous work it was shown that ethylene participates in the up-regulation of several Fe acquisition genes of Arabidopsis, such as AtFIT, AtFRO2, and AtIRT1.	Iron	91-93	iron-regulated transporter 1	Arabidopsis thaliana	155-161
20627899-6	2010	Further studies were performed to analyse whether Fe deficiency up-regulates the expression of genes involved in ethylene biosynthesis [S-adenosylmethionine synthetase, 1-aminocyclopropane-1-carboxylate (ACC) synthase, and ACC oxidase genes] and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3).	Iron	50-52	Signal transduction histidine kinase, hybrid-type, ethylene sensor	Arabidopsis thaliana	258-264
20627899-6	2010	Further studies were performed to analyse whether Fe deficiency up-regulates the expression of genes involved in ethylene biosynthesis [S-adenosylmethionine synthetase, 1-aminocyclopropane-1-carboxylate (ACC) synthase, and ACC oxidase genes] and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3).	Iron	50-52	ETHYLENE-INSENSITIVE3-like 1	Arabidopsis thaliana	290-296
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	ACC oxidase 1	Arabidopsis thaliana	145-151
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	ACC oxidase 2	Arabidopsis thaliana	157-163
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	Signal transduction histidine kinase, hybrid-type, ethylene sensor	Arabidopsis thaliana	181-187
20627899-8	2010	In addition, the results show that Fe deficiency up-regulates genes involved in both ethylene synthesis (AtSAM1, AtSAM2, AtACS4, AtACS6, AtACS9, AtACO1, and AtACO2) and signalling (AtETR1, AtCTR1, AtEIN2, AtEIN3, AtEIL1, and AtEIL3) in the roots.	Iron	35-37	ETHYLENE-INSENSITIVE3-like 1	Arabidopsis thaliana	213-219
20797578-4	2010	Both EPO fluctuation and the release of iron-deficient RBCs are characteristic events occurring during the management of renal anemia, and the shorter RBC lifetime is a component of the large fluctuations in hemoglobin level seen in patients on hemodialysis.	Iron	40-44	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	55-58
20411304-9	2010	The data suggested that the induced elevation of NO level by exercise lead to the up-regulation of both TfR1 and DMT1 (IRE), which in turn increasing the iron absorption in skeletal muscle.	Iron	154-158	RoBo-1	Rattus norvegicus	113-117
21117298-2	2010	Bacterial pathogens could multiply in the animal body because they produce iron-binding siderophores that help them to obtain iron from transferrin, lactoferrin or ferritin of their host.	Iron	75-79	transferrin	Mus musculus	136-147
21117298-2	2010	Bacterial pathogens could multiply in the animal body because they produce iron-binding siderophores that help them to obtain iron from transferrin, lactoferrin or ferritin of their host.	Iron	126-130	transferrin	Mus musculus	136-147
20542038-5	2010	In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	38-46
20179090-3	2010	In the plasma, iron binds to transferrin and is made available for de novo red cell synthesis.	Iron	15-19	transferrin	Mus musculus	29-40
20683946-5	2010	Transcripts of seven enzymes in the cholesterol biosynthesis pathway were significantly up-regulated with increasing hepatic iron (R(2) between 0.602 and 0.164), including those of the rate-limiting enzyme, 3-hydroxy-3-methylglutarate-coenzyme A reductase (Hmgcr; R(2) = 0.362, P &lt; 0.002).	Iron	125-129	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	207-255
20683946-5	2010	Transcripts of seven enzymes in the cholesterol biosynthesis pathway were significantly up-regulated with increasing hepatic iron (R(2) between 0.602 and 0.164), including those of the rate-limiting enzyme, 3-hydroxy-3-methylglutarate-coenzyme A reductase (Hmgcr; R(2) = 0.362, P &lt; 0.002).	Iron	125-129	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	257-262
20596614-1	2010	Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein with roles in iron trafficking as well as in carcinogenesis and progression of several human neoplasias.	Iron	84-88	lipocalin 2	Homo sapiens	0-42
20596614-1	2010	Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein with roles in iron trafficking as well as in carcinogenesis and progression of several human neoplasias.	Iron	84-88	lipocalin 2	Homo sapiens	44-48
20675571-6	2010	Moreover, ILR3 interacts with a third protein, BRUTUS (BTS), a putative E3 ligase protein, with metal ion binding and DNA binding domains, which negatively regulates the response to iron deficiency.	Iron	182-186	zinc finger protein-like protein	Arabidopsis thaliana	47-53
20399759-9	2010	These results suggest that IRP2 binding activity reduces ferritin expression in the striatum after ICH, preventing an optimal response to elevated local iron concentrations.	Iron	153-157	iron responsive element binding protein 2	Mus musculus	27-31
20043814-0	2010	Up-regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-target genes in cortical neurons by the novel multifunctional iron chelator anti-Alzheimer drug, M30.	Iron	125-129	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	17-54
20594231-2	2010	Although copper and iron metabolism are closely linked, the influence of mutations of the ATP7B gene on iron homeostasis is unknown.	Iron	104-108	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	90-95
20594231-3	2010	Therefore, the present study was carried out to elucidate iron metabolism in Atp7b(-/-) mice, an animal model of Wilson disease.	Iron	58-62	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	77-82
20594231-6	2010	RESULTS: Atp7b(-/-) mice displayed copper accumulation (P < 0.001), slightly elevated hepatic iron content (P = NS), and a low serum ceruloplasmin oxidase activity (1.5 +/- 1.9 U/L vs 18.9 +/- 4.0 U/L, P < 0.001) when compared with wild type mice.	Iron	94-98	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	9-14
20594231-10	2010	CONCLUSION: Atp7b(-/-) mice demonstrated decreased serum iron parameters and hemoglobin levels most likely related to a low serum ceruloplasmin oxidase activity and not due to total body iron deficiency.	Iron	57-61	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	12-17
20598050-1	2010	AIM: Sri Lanka has a policy of free provision of iron supplements to pregnant women.	Iron	49-53	sorcin	Homo sapiens	5-8
20353168-9	2010	YC-1 binding also strains the Fe-histidine bond, leading to a population of the five-coordinate sGC-CO complex in addition to a conformationally distinct population of the six-coordinate sGC-CO complex.	Iron	30-32	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4
20447525-7	2010	Neutrophil gelatinase-associated lipocalin participates in local iron transport.	Iron	65-69	lipocalin 2	Homo sapiens	0-42
20053755-2	2010	Iron metabolism is controlled by hepcidin, a 25-amino acid peptide.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	33-41
20053755-3	2010	Hepcidin is induced by inflammation, causes iron to be sequestered, and thus, potentially contributes to AI.	Iron	44-48	hepcidin antimicrobial peptide	Mus musculus	0-8
20345096-4	2010	An iron-binding assay showed that the rLF retained iron-binding activity and the binding capacity of 1 mg/mL rLF would be saturated by 100 microM of FeCl(3).	Iron	3-7	RLF zinc finger	Rattus norvegicus	38-41
20345096-4	2010	An iron-binding assay showed that the rLF retained iron-binding activity and the binding capacity of 1 mg/mL rLF would be saturated by 100 microM of FeCl(3).	Iron	3-7	RLF zinc finger	Rattus norvegicus	109-112
20345096-4	2010	An iron-binding assay showed that the rLF retained iron-binding activity and the binding capacity of 1 mg/mL rLF would be saturated by 100 microM of FeCl(3).	Iron	51-55	RLF zinc finger	Rattus norvegicus	38-41
20110460-0	2010	Hemochromatosis and pregnancy: iron stores in the Hfe-/- mouse are not reduced by multiple pregnancies.	Iron	31-35	homeostatic iron regulator	Mus musculus	50-53
20110460-5	2010	The Hfe-/- mouse model recapitulates key aspects of HH, including an iron overload phenotype similar to that observed in human patients.	Iron	69-73	homeostatic iron regulator	Mus musculus	4-7
20086155-0	2010	Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition.	Iron	132-136	lipocalin 2	Homo sapiens	0-42
20086155-2	2010	Iron complexes of NE resemble those of bacterial siderophores that are scavenged by human neutrophil gelatinase-associated lipocalin (NGAL) as part of the innate immune defense.	Iron	0-4	lipocalin 2	Homo sapiens	90-132
20086155-2	2010	Iron complexes of NE resemble those of bacterial siderophores that are scavenged by human neutrophil gelatinase-associated lipocalin (NGAL) as part of the innate immune defense.	Iron	0-4	lipocalin 2	Homo sapiens	134-138
20086155-3	2010	Here, we show that NGAL binds iron-complexed NE, indicating physiological relevance for both bacterial and human iron metabolism.	Iron	30-34	lipocalin 2	Homo sapiens	19-23
20086155-3	2010	Here, we show that NGAL binds iron-complexed NE, indicating physiological relevance for both bacterial and human iron metabolism.	Iron	113-117	lipocalin 2	Homo sapiens	19-23
20086155-11	2010	This study demonstrates for the first time that human NGAL not only neutralizes pathogen-derived virulence factors but also can effectively scavenge an iron-chelate complex abundant in the host.	Iron	152-156	lipocalin 2	Homo sapiens	54-58
19453575-3	2010	It was reported that individual immunological profile of CD8+ T-lymphocytes may have a modifying effect on the severity of iron overload in HFE homozygous hemochromatosis patients, with low numbers being negatively correlated with the total amount of body iron stores.	Iron	123-127	CD8a molecule	Homo sapiens	57-60
19453575-3	2010	It was reported that individual immunological profile of CD8+ T-lymphocytes may have a modifying effect on the severity of iron overload in HFE homozygous hemochromatosis patients, with low numbers being negatively correlated with the total amount of body iron stores.	Iron	256-260	CD8a molecule	Homo sapiens	57-60
20136718-2	2010	Lactoferrin (Lac) is an iron-binding glycoprotein that belongs to the transferrin family.	Iron	24-28	transferrin	Mus musculus	70-81
19655216-2	2010	Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1).	Iron	16-20	RoBo-1	Rattus norvegicus	83-111
19655216-2	2010	Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1).	Iron	16-20	RoBo-1	Rattus norvegicus	113-117
19655216-3	2010	The N-terminus (1A, 1B) and C-terminus (+IRE, -IRE) splice variants of DMT1 originate four protein isoforms, all of which supply iron to cells.	Iron	129-133	RoBo-1	Rattus norvegicus	71-75
20360937-1	2010	Under physiological conditions, transferrin receptor 2 (TfR2) is expressed in the liver and its balance is related to the cell cycle rather than to intracellular iron levels.	Iron	162-166	transferrin receptor 2	Mus musculus	32-54
20360937-1	2010	Under physiological conditions, transferrin receptor 2 (TfR2) is expressed in the liver and its balance is related to the cell cycle rather than to intracellular iron levels.	Iron	162-166	transferrin receptor 2	Mus musculus	56-60
20162191-0	2010	Spin crossover in a heptanuclear mixed-valence iron complex.	Iron	47-51	spindlin 1	Homo sapiens	0-4
20045050-0	2010	Hepcidin induction limits mobilisation of splenic iron in a mouse model of secondary iron overload.	Iron	50-54	hepcidin antimicrobial peptide	Mus musculus	0-8
20045050-0	2010	Hepcidin induction limits mobilisation of splenic iron in a mouse model of secondary iron overload.	Iron	85-89	hepcidin antimicrobial peptide	Mus musculus	0-8
20045050-10	2010	In conclusion, our model of secondary iron overload led to decreased plasma iron associated with an increase in hepcidin expression and subsequent restriction of iron export from the spleen.	Iron	38-42	hepcidin antimicrobial peptide	Mus musculus	112-120
19892014-3	2010	In this study, we show that SCF induces transient tyrosine phosphorylation of wild-type Fes as well as kinase-dead Fes in bone marrow-derived mast cells (BMMCs).	Iron	88-91	KIT ligand	Homo sapiens	28-31
19892014-7	2010	SCF-treated Fes-deficient BMMCs also displayed elevated beta1 integrin-mediated cell adhesion and spreading on fibronectin, compared to control cells, and a reduction in cell polarization at later times of SCF treatment.	Iron	12-15	KIT ligand	Homo sapiens	0-3
19892014-7	2010	SCF-treated Fes-deficient BMMCs also displayed elevated beta1 integrin-mediated cell adhesion and spreading on fibronectin, compared to control cells, and a reduction in cell polarization at later times of SCF treatment.	Iron	12-15	integrin subunit beta 1	Homo sapiens	56-70
19892014-7	2010	SCF-treated Fes-deficient BMMCs also displayed elevated beta1 integrin-mediated cell adhesion and spreading on fibronectin, compared to control cells, and a reduction in cell polarization at later times of SCF treatment.	Iron	12-15	KIT ligand	Homo sapiens	206-209
19892014-9	2010	Interestingly, SCF-induced chemotaxis of BMMCs was also defective in Fes-deficient BMMCs, and restored in Fes-rescue BMMCs.	Iron	69-72	KIT ligand	Homo sapiens	15-18
19892014-9	2010	Interestingly, SCF-induced chemotaxis of BMMCs was also defective in Fes-deficient BMMCs, and restored in Fes-rescue BMMCs.	Iron	106-109	KIT ligand	Homo sapiens	15-18
20125122-4	2010	In the present study, we observed that in the SN of 6-hydroxydopamine (6-OHDA)-induced PD rats, DMT1 with the iron responsive element (IRE, DMT1+IRE), but not DMT1 without IRE (DMT1-IRE), was up-regulated, suggesting that increased DMT1+IRE expression might account for nigral iron accumulation in PD rats.	Iron	110-114	RoBo-1	Rattus norvegicus	96-100
20125122-4	2010	In the present study, we observed that in the SN of 6-hydroxydopamine (6-OHDA)-induced PD rats, DMT1 with the iron responsive element (IRE, DMT1+IRE), but not DMT1 without IRE (DMT1-IRE), was up-regulated, suggesting that increased DMT1+IRE expression might account for nigral iron accumulation in PD rats.	Iron	277-281	RoBo-1	Rattus norvegicus	96-100
20057160-1	2010	BACKGROUND: Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role in inflammation.	Iron	113-117	lipocalin 2	Homo sapiens	12-23
20057160-1	2010	BACKGROUND: Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role in inflammation.	Iron	113-117	lipocalin 2	Homo sapiens	70-74
20057160-1	2010	BACKGROUND: Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role in inflammation.	Iron	113-117	lipocalin 2	Homo sapiens	75-79
20133002-0	2010	Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis.	Iron	0-4	transferrin	Mus musculus	24-35
20133002-0	2010	Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis.	Iron	0-4	transferrin receptor 2	Mus musculus	41-63
20133002-2	2010	TFR2 has been shown to mediate iron transport in vitro and regulate iron homeostasis.	Iron	31-35	transferrin receptor 2	Mus musculus	0-4
20133002-2	2010	TFR2 has been shown to mediate iron transport in vitro and regulate iron homeostasis.	Iron	68-72	transferrin receptor 2	Mus musculus	0-4
20133002-3	2010	The aim of this study was to determine the role of Tfr2 in iron transport in vivo using a Tfr2 mutant mouse.	Iron	59-63	transferrin receptor 2	Mus musculus	51-55
20133002-4	2010	METHODS: Tfr2 mutant and wild-type mice were injected intravenously with (59)Fe-transferrin and tissue (59)Fe uptake was measured.	Iron	77-79	transferrin	Mus musculus	80-91
20133002-7	2010	RESULTS: Transferrin-bound iron uptake by the liver and spleen in Tfr2 mutant mice was reduced by 20% and 65%, respectively, whilst duodenal and renal uptake was unchanged compared with iron-loaded wild-type mice.	Iron	27-31	transferrin	Mus musculus	9-20
20133002-7	2010	RESULTS: Transferrin-bound iron uptake by the liver and spleen in Tfr2 mutant mice was reduced by 20% and 65%, respectively, whilst duodenal and renal uptake was unchanged compared with iron-loaded wild-type mice.	Iron	27-31	transferrin receptor 2	Mus musculus	66-70
20133002-11	2010	CONCLUSIONS: A small reduction in hepatic transferrin-bound iron uptake in Tfr2 mutant mice suggests that Tfr2 plays a minor role in liver iron transport and its primary role is to regulate iron metabolism.	Iron	60-64	transferrin	Mus musculus	42-53
20133002-11	2010	CONCLUSIONS: A small reduction in hepatic transferrin-bound iron uptake in Tfr2 mutant mice suggests that Tfr2 plays a minor role in liver iron transport and its primary role is to regulate iron metabolism.	Iron	60-64	transferrin receptor 2	Mus musculus	75-79
20133002-11	2010	CONCLUSIONS: A small reduction in hepatic transferrin-bound iron uptake in Tfr2 mutant mice suggests that Tfr2 plays a minor role in liver iron transport and its primary role is to regulate iron metabolism.	Iron	60-64	transferrin receptor 2	Mus musculus	106-110
20133002-11	2010	CONCLUSIONS: A small reduction in hepatic transferrin-bound iron uptake in Tfr2 mutant mice suggests that Tfr2 plays a minor role in liver iron transport and its primary role is to regulate iron metabolism.	Iron	139-143	transferrin receptor 2	Mus musculus	106-110
20133002-11	2010	CONCLUSIONS: A small reduction in hepatic transferrin-bound iron uptake in Tfr2 mutant mice suggests that Tfr2 plays a minor role in liver iron transport and its primary role is to regulate iron metabolism.	Iron	139-143	transferrin receptor 2	Mus musculus	106-110
20133002-12	2010	Increased ferroportin expression due to decreased hepcidin mRNA levels is likely to be responsible for impaired splenic iron uptake in Tfr2 mutant mice.	Iron	120-124	hepcidin antimicrobial peptide	Mus musculus	50-58
20001966-0	2010	Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region.	Iron	0-4	transcriptional co-activator mating type protein alpha	Saccharomyces cerevisiae S288C	82-94
19957947-2	2010	The Delta yfh1 mutant is unusual in that it accumulates iron in it is mitochondria.	Iron	56-60	ferroxidase	Saccharomyces cerevisiae S288C	10-14
20019189-0	2010	Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis.	Iron	0-4	MDM2 proto-oncogene	Homo sapiens	29-33
20019189-4	2010	Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis.	Iron	0-4	MDM2 proto-oncogene	Homo sapiens	29-33
20019189-4	2010	Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis.	Iron	99-103	MDM2 proto-oncogene	Homo sapiens	29-33
20019189-5	2010	Iron status influenced p53 ubiquitination and degradation rate, and the MDM2 inhibitor nutlin increased p53 levels in iron-depleted cells.	Iron	118-122	MDM2 proto-oncogene	Homo sapiens	72-76
20019189-7	2010	The MDM2 -309T &gt; G promoter polymorphism, determining increased MDM2 and lower p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma.	Iron	315-319	MDM2 proto-oncogene	Homo sapiens	4-8
20019189-7	2010	The MDM2 -309T &gt; G promoter polymorphism, determining increased MDM2 and lower p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma.	Iron	315-319	MDM2 proto-oncogene	Homo sapiens	67-71
20019189-7	2010	The MDM2 -309T &gt; G promoter polymorphism, determining increased MDM2 and lower p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma.	Iron	315-319	MDM2 proto-oncogene	Homo sapiens	67-71
20019189-8	2010	In conclusion, iron status influences p53 activity and antioxidant response by modulating MDM2 expression.	Iron	15-19	MDM2 proto-oncogene	Homo sapiens	90-94
20019189-9	2010	MDM2 inhibitors may enhance the antiproliferative activity of iron chelators.	Iron	62-66	MDM2 proto-oncogene	Homo sapiens	0-4
20017200-12	2010	CONCLUSION: Huh-7 cells may represent a novel and valuable tool to investigate the role of altered HFE traffic in iron metabolism and pathogenesis of human HFE HC.	Iron	114-118	MIR7-3 host gene	Homo sapiens	12-17
19900513-7	2010	In contrast, TNF-alpha stabilized lysosomes and protected cells, particularly those iron-exposed, by reducing cellular iron and increasing H-ferritin.	Iron	84-88	ferritin heavy polypeptide 1	Mus musculus	139-149
19965627-0	2010	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.	Iron	91-95	ferrochelatase	Homo sapiens	60-74
19965627-0	2010	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.	Iron	120-124	ferrochelatase	Homo sapiens	60-74
19965627-1	2010	Mammalian ferrochelatase, the terminal enzyme in the heme biosynthetic pathway, possesses an iron-sulfur [2Fe-2S] cluster that does not participate in catalysis.	Iron	93-97	ferrochelatase	Homo sapiens	10-24
19965627-2	2010	We investigated ferrochelatase expression in iron-deficient erythropoietic tissues of mice lacking iron regulatory protein 2, in iron-deficient murine erythroleukemia cells, and in human patients with ISCU myopathy.	Iron	45-49	ferrochelatase	Mus musculus	16-30
19965627-6	2010	Ferrochelatase was also severely depleted in muscle biopsies and cultured myoblasts from patients with ISCU myopathy, a disease caused by deficiency of a scaffold protein required for Fe-S cluster assembly.	Iron	184-188	ferrochelatase	Homo sapiens	0-14
19965627-7	2010	Together, these data suggest that decreased Fe-S cluster availability because of cellular iron depletion or impaired Fe-S cluster assembly causes reduced maturation and stabilization of apo-ferrochelatase, providing a direct link between Fe-S biogenesis and completion of heme biosynthesis.	Iron	44-48	ferrochelatase	Homo sapiens	190-204
19965627-7	2010	Together, these data suggest that decreased Fe-S cluster availability because of cellular iron depletion or impaired Fe-S cluster assembly causes reduced maturation and stabilization of apo-ferrochelatase, providing a direct link between Fe-S biogenesis and completion of heme biosynthesis.	Iron	90-94	ferrochelatase	Homo sapiens	190-204
19965627-7	2010	Together, these data suggest that decreased Fe-S cluster availability because of cellular iron depletion or impaired Fe-S cluster assembly causes reduced maturation and stabilization of apo-ferrochelatase, providing a direct link between Fe-S biogenesis and completion of heme biosynthesis.	Iron	117-121	ferrochelatase	Homo sapiens	190-204
19965627-7	2010	Together, these data suggest that decreased Fe-S cluster availability because of cellular iron depletion or impaired Fe-S cluster assembly causes reduced maturation and stabilization of apo-ferrochelatase, providing a direct link between Fe-S biogenesis and completion of heme biosynthesis.	Iron	117-121	ferrochelatase	Homo sapiens	190-204
21490909-7	2010	ROC curve analysis for RSf in the diagnosis of iron restricted erythropoiesis defined as CHr &lt; 28 pg: AUC 0.983; Cutoff 91.1%; Sensitivity 98.8%; Specificity 89.6% Correlation between LHD% and %Hypo, r = 0.869.	Iron	47-51	chromate resistance; sulfate transport	Homo sapiens	89-92
19897459-14	2010	Acquisition of the Al and Fe incorporated into clay derives principally from hydraulic uplift from ground water via deeply penetrating tap roots.	Iron	26-28	nuclear RNA export factor 1	Homo sapiens	135-138
20622448-0	2010	Porcine ferrochelatase: the relationship between iron-removal reaction and the conversion of heme to Zn-protoporphyrin.	Iron	49-53	ferrochelatase	Homo sapiens	8-22
20622448-5	2010	To characterize the iron-removal reverse activity of FECH, we examined its properties in porcine liver and muscle mitochondria, and isolated porcine FECH cDNA.	Iron	20-24	ferrochelatase	Homo sapiens	53-57
20511703-10	2010	Meanwhile, down-regulation of DMT1 and up-regulation of MTP1 were induced to alleviate the excessive iron in the myocardium.	Iron	101-105	RoBo-1	Rattus norvegicus	30-34
20502037-4	2010	The aim of this review is to summarize the current knowledge dealing with a possible role of hepcidin and NGAL in iron metabolism and its regulation, particularly in kidney disease.	Iron	114-118	lipocalin 2	Homo sapiens	106-110
20502037-7	2010	NGAL binds siderophores, thereby preventing iron uptake by bacteria.	Iron	44-48	lipocalin 2	Homo sapiens	0-4
20424477-10	2010	NGAL could reflect both kidney function and iron metabolism.	Iron	44-48	lipocalin 2	Homo sapiens	0-4
20424477-11	2010	Taking into account the antimicrobial properties of NGAL, further studies are needed to address the role of NGAL in iron metabolism and inflammation in renal failure.	Iron	116-120	lipocalin 2	Homo sapiens	108-112
19588900-0	2009	Spin-polarized density functional theory study of reactivity of diatomic molecule on bimetallic system: the case of O2 dissociative adsorption on Pt monolayer on Fe(001).	Iron	162-164	spindlin 1	Homo sapiens	0-4
19954242-2	2009	Among them, the nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana deserves particular attention, as it combines an extremely high oxygen affinity with an internal hexacoordination of the distal histidine HisE7 to the heme iron in the absence of exogenous ligands.	Iron	227-231	hemoglobin 1	Arabidopsis thaliana	40-44
19649569-0	2009	Deficiency in frataxin homologue YFH1 in the yeast Pichia  guilliermondii leads to missregulation of iron acquisition  and riboflavin biosynthesis and affects sulfate assimilation.	Iron	101-105	ferroxidase	Saccharomyces cerevisiae S288C	33-37
19649569-2	2009	P. guilliermondii YFH1 gene coding for frataxin homologue, eukaryotic mitochondrial protein involved in iron trafficking and storage, was identified and deleted.	Iron	104-108	ferroxidase	Saccharomyces cerevisiae S288C	18-22
19824072-0	2009	Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.	Iron	106-110	homeostatic iron regulator	Mus musculus	21-24
19824072-0	2009	Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.	Iron	106-110	transferrin receptor 2	Mus musculus	29-51
19824072-1	2009	UNLABELLED: Hepcidin is a central regulator of iron homeostasis.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	12-20
19824072-2	2009	HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron.	Iron	156-160	homeostatic iron regulator	Mus musculus	0-3
19824072-2	2009	HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron.	Iron	156-160	transferrin receptor 2	Mus musculus	8-30
19824072-2	2009	HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron.	Iron	156-160	transferrin receptor 2	Mus musculus	32-36
19824072-2	2009	HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron.	Iron	156-160	hepcidin antimicrobial peptide	Mus musculus	132-140
19824072-9	2009	Double-null mice had more severe iron loading than mice lacking either Hfe or Tfr2; Tfr2 null mice had a greater iron burden than Hfe-null mice.	Iron	113-117	transferrin receptor 2	Mus musculus	84-88
19824072-13	2009	CONCLUSION: These studies demonstrate that iron overload due to deletion of Tfr2 is more severe than that due to Hfe, and that loss of both molecules results in pronounced iron overload.	Iron	43-47	transferrin receptor 2	Mus musculus	76-80
19549696-0	2009	Neutrophil gelatinase-associated lipocalin (NGAL) reflects iron status in haemodialysis patients.	Iron	59-63	lipocalin 2	Homo sapiens	0-42
19549696-0	2009	Neutrophil gelatinase-associated lipocalin (NGAL) reflects iron status in haemodialysis patients.	Iron	59-63	lipocalin 2	Homo sapiens	44-48
19700664-3	2009	This increased resistance is paralleled by an enhanced production of the enterochelin-binding peptide lipocalin-2 (Lcn2), which reduces the availability of iron for Salmonella within Hfe-deficient macrophages.	Iron	156-160	homeostatic iron regulator	Mus musculus	183-186
19703464-4	2009	One unanswered question about ferrochelatase involves defining the mechanism whereby some metals, such as divalent Fe, Co, Ni, and Zn, can be used by the enzyme in vitro to produce the corresponding metalloporphyrins, while other metals, such as divalent Mn, Hg, Cd, or Pb, are inhibitors of the enzyme.	Iron	115-117	ferrochelatase	Homo sapiens	30-44
19732771-7	2009	Fps/Fes was found to be a component of the E-cadherin adherens junction (AJ) complex; however, the phosphotyrosine status of beta-catenin and core AJ components in fps/fes-null breast tissue was unaltered, and epithelial cell AJs and gland morphology were intact.	Iron	168-171	catenin (cadherin associated protein), beta 1	Mus musculus	125-137
19715344-3	2009	However, the interactions between these proteins and the iron-dependent mechanism by which they control Aft1 localization are unclear.	Iron	57-61	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	104-108
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	105-109	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	82-88
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	105-109	Bol2p	Saccharomyces cerevisiae S288C	93-97
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	105-109	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	82-86
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	105-107	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	82-88
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	105-107	Bol2p	Saccharomyces cerevisiae S288C	93-97
19715344-8	2009	Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue.	Iron	105-107	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	82-86
19715344-9	2009	Overall, these results suggest that the ability of the Fra2-Grx3/4 complex to assemble a [2Fe-2S] cluster may act as a signal to control the iron regulon in response to cellular iron status in yeast.	Iron	141-145	Bol2p	Saccharomyces cerevisiae S288C	55-59
19715344-9	2009	Overall, these results suggest that the ability of the Fra2-Grx3/4 complex to assemble a [2Fe-2S] cluster may act as a signal to control the iron regulon in response to cellular iron status in yeast.	Iron	178-182	Bol2p	Saccharomyces cerevisiae S288C	55-59
19330300-3	2009	We found tissue specific changes in sla and nutritional iron deficiency including decreased liver Hamp1 expression and increased protein expression of the enterocyte basolateral iron transport components, hephaestin and ferroportin.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	98-103
19695670-5	2009	Temporal changes in the concentrations of Al, Cr, Li, Ni, and Fe correlated with PFL intensities of small MS fractions, while variations in the concentrations of As, Co, Mn, and Pb were largely explained by UVA and PFL intensities of humic fractions.	Iron	62-64	profilin 2	Homo sapiens	81-84
19591830-2	2009	Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating that HFE regulates hepcidin.	Iron	19-23	hepcidin antimicrobial peptide	Mus musculus	44-52
19591830-9	2009	However, levels of hepatic phosphorylated Smad 1/5/8 protein (an intracellular mediator of Bmp6 signaling) and Id1 mRNA (a target gene of Bmp6) were inappropriately low for the body iron burden and Bmp6 mRNA levels in Hfe KO, compared with WT mice.	Iron	182-186	inhibitor of DNA binding 1, HLH protein	Mus musculus	111-114
19591830-11	2009	CONCLUSIONS: HFE is not involved in regulation of BMP6 by iron, but does regulate the downstream signals of BMP6 that are triggered by iron.	Iron	135-139	homeostatic iron regulator	Mus musculus	13-16
19895077-3	2009	Capabilities of the instrument are demonstrated with preliminary results on the development of textures in the bcc, fcc, and hcp polymorphs of iron during a nonhydrostatic compression experiment at simultaneous high pressure and high temperature.	Iron	143-147	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	125-128
19787063-2	2009	HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the iron-regulatory hormone, hepcidin, which results in increased iron absorption.	Iron	97-101	homeostatic iron regulator	Mus musculus	0-3
19787063-2	2009	HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the iron-regulatory hormone, hepcidin, which results in increased iron absorption.	Iron	97-101	hepcidin antimicrobial peptide	Mus musculus	122-130
19787063-3	2009	The liver is crucial for iron homeostasis as it is the main production site of hepcidin.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	79-87
19805308-3	2009	Using cardiac tissues, we demonstrate that frataxin deficiency leads to down-regulation of key molecules involved in 3 mitochondrial utilization pathways: iron-sulfur cluster (ISC) synthesis (iron-sulfur cluster scaffold protein1/2 and the cysteine desulferase Nfs1), mitochondrial iron storage (mitochondrial ferritin), and heme synthesis (5-aminolevulinate dehydratase, coproporphyrinogen oxidase, hydroxymethylbilane synthase, uroporphyrinogen III synthase, and ferrochelatase).	Iron	192-196	frataxin	Mus musculus	43-51
19697914-0	2009	Accurate computed enthalpies of spin crossover in iron and cobalt complexes.	Iron	50-54	spindlin 1	Homo sapiens	32-36
19540797-1	2009	A new pyridine-2,6-dicarboxylate iron(III)/iron(II) complex [Fe(phen)(3)][Fe(2)(PDC)(4)].3CH(3)OH was synthesized and characterized (where PDC=pyridine-2,6-dicarboxylate, phen=1,10-phenanthroline) by using elemental analysis, IR spectroscopy and thermal analyses (TGA and DTA).	Iron	33-37	phosducin	Homo sapiens	80-83
19540797-1	2009	A new pyridine-2,6-dicarboxylate iron(III)/iron(II) complex [Fe(phen)(3)][Fe(2)(PDC)(4)].3CH(3)OH was synthesized and characterized (where PDC=pyridine-2,6-dicarboxylate, phen=1,10-phenanthroline) by using elemental analysis, IR spectroscopy and thermal analyses (TGA and DTA).	Iron	33-37	phosducin	Homo sapiens	139-142
19540797-1	2009	A new pyridine-2,6-dicarboxylate iron(III)/iron(II) complex [Fe(phen)(3)][Fe(2)(PDC)(4)].3CH(3)OH was synthesized and characterized (where PDC=pyridine-2,6-dicarboxylate, phen=1,10-phenanthroline) by using elemental analysis, IR spectroscopy and thermal analyses (TGA and DTA).	Iron	43-47	phosducin	Homo sapiens	80-83
19540797-1	2009	A new pyridine-2,6-dicarboxylate iron(III)/iron(II) complex [Fe(phen)(3)][Fe(2)(PDC)(4)].3CH(3)OH was synthesized and characterized (where PDC=pyridine-2,6-dicarboxylate, phen=1,10-phenanthroline) by using elemental analysis, IR spectroscopy and thermal analyses (TGA and DTA).	Iron	43-47	phosducin	Homo sapiens	139-142
19792339-3	2009	Inelastic spin excitation spectroscopy with scanning tunneling microscopy is used to probe the Kondo effect of a Co atom, supported on a thin insulating layer on a Cu substrate, that is weakly coupled to a nearby Fe atom to form an inhomogeneous dimer.	Iron	213-215	spindlin 1	Homo sapiens	10-14
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Iron	133-137	complement C3	Homo sapiens	178-181
19697924-4	2009	In silico P450 3A4 active site docking of Cmpd A exhibited a low energy pose that orientated the pyrazole ring proximate to the heme iron atom, in which the distance between the C-3 and potential activated oxygen species was shown to be 3.4 A. Quantum molecular calculations showed that the electron density on C-3 was relatively higher than those on C-4 and C-5.	Iron	133-137	complement C3	Homo sapiens	311-314
19574226-1	2009	In Saccharomyces cerevisiae, ARN1 encodes a transporter for the uptake of ferrichrome, an important nutritional source of iron.	Iron	122-126	siderophore transporter	Saccharomyces cerevisiae S288C	29-33
19792825-2	2009	In the case of spin-1 iron atoms, large enough Heisenberg exchange interactions between neighboring spin-1/2 moments on different iron 3d orbitals that frustrate true magnetic order lead to hidden magnetic order that violates Hund"s rule.	Iron	22-26	spindlin 1	Homo sapiens	15-21
19792825-2	2009	In the case of spin-1 iron atoms, large enough Heisenberg exchange interactions between neighboring spin-1/2 moments on different iron 3d orbitals that frustrate true magnetic order lead to hidden magnetic order that violates Hund"s rule.	Iron	22-26	spindlin 1	Homo sapiens	100-108
19491103-2	2009	Analysis of highly conserved components of the yeast ISC assembly machinery shows that the iron-chaperone, Yfh1, and the sulfur-donor complex, Nfs1-Isd11, directly bind to each other.	Iron	91-95	ferroxidase	Saccharomyces cerevisiae S288C	107-111
19491103-5	2009	Binding of Yfh1 to Nfs1-Isd11 or Isu1 requires oligomerization of Yfh1 and can occur in an iron-independent manner.	Iron	91-95	ferroxidase	Saccharomyces cerevisiae S288C	11-15
19679815-7	2009	The regulation of hepcidin by ER stress links the intracellular response involved in protein quality control to innate immunity and iron homeostasis.	Iron	132-136	hepcidin antimicrobial peptide	Mus musculus	18-26
19426170-1	2009	BACKGROUND/AIMS: Expression of Hamp1, the gene encoding the iron regulatory peptide hepcidin, is inappropriately low in HFE-associated hereditary hemochromatosis and Hfe knockout mice (Hfe(-/-)).	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	31-36
19426170-1	2009	BACKGROUND/AIMS: Expression of Hamp1, the gene encoding the iron regulatory peptide hepcidin, is inappropriately low in HFE-associated hereditary hemochromatosis and Hfe knockout mice (Hfe(-/-)).	Iron	60-64	hepcidin antimicrobial peptide	Mus musculus	84-92
19656490-6	2009	Moreover, silencing of Slc25a39 in murine erythroleukemia cells impaired iron incorporation into protoporphyrin IX, and vertebrate Slc25a39 complemented an iron homeostasis defect in the orthologous yeast mtm1Delta deletion mutant.	Iron	73-77	solute carrier family 25, member 39	Mus musculus	23-31
19656490-6	2009	Moreover, silencing of Slc25a39 in murine erythroleukemia cells impaired iron incorporation into protoporphyrin IX, and vertebrate Slc25a39 complemented an iron homeostasis defect in the orthologous yeast mtm1Delta deletion mutant.	Iron	156-160	solute carrier family 25, member 39	Mus musculus	131-139
19345459-0	2009	Dynamic and equilibrium studies of the RDX removal from soil using CMC-coated zerovalent iron nanoparticles.	Iron	89-93	radixin	Homo sapiens	39-42
19542287-8	2009	Finally, it appears that two sequence motifs, the Walker A box involved in ATP binding and an iron-sulfur-cysteine cluster, are present only in subsets of AddB proteins, suggesting the existence of mechanistically distinct classes of AddB.	Iron	94-98	adducin 2	Homo sapiens	155-159
19542287-8	2009	Finally, it appears that two sequence motifs, the Walker A box involved in ATP binding and an iron-sulfur-cysteine cluster, are present only in subsets of AddB proteins, suggesting the existence of mechanistically distinct classes of AddB.	Iron	94-98	adducin 2	Homo sapiens	234-238
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	62-66	transferrin	Mus musculus	6-17
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	68-70	transferrin	Mus musculus	6-17
19245822-1	2009	Melanotransferrin (MTf) is a transferrin homologue that binds iron (Fe) through a high affinity Fe-binding site.	Iron	96-98	transferrin	Mus musculus	6-17
19594550-10	2009	Serum LDH, ALT and AST activity, as well as MDA content, GRP78 expression and caspase 12 activity in the heart and liver, were upregulated in chronically iron-loaded rats.	Iron	154-158	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	57-62
19594550-10	2009	Serum LDH, ALT and AST activity, as well as MDA content, GRP78 expression and caspase 12 activity in the heart and liver, were upregulated in chronically iron-loaded rats.	Iron	154-158	caspase 12	Rattus norvegicus	78-88
19366850-3	2009	We recently reported a case of iron-induced hypophosphatemic osteomalacia associated with marked FGF23 elevation.	Iron	31-35	fibroblast growth factor 23	Homo sapiens	97-102
19397338-9	2009	Mia40, as isolated, shows a visible spectrum characteristic of an Fe-S center and contains 0.56 +/- 0.02 atom of iron per subunit.	Iron	66-70	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	0-5
19397338-9	2009	Mia40, as isolated, shows a visible spectrum characteristic of an Fe-S center and contains 0.56 +/- 0.02 atom of iron per subunit.	Iron	113-117	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	0-5
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	42-46	homeostatic iron regulator	Mus musculus	147-150
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	42-46	transferrin receptor 2	Mus musculus	206-228
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	homeostatic iron regulator	Mus musculus	147-150
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	243-251
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hemojuvelin BMP co-receptor	Mus musculus	256-259
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hemojuvelin BMP co-receptor	Mus musculus	261-273
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	homeostatic iron regulator	Mus musculus	147-150
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	243-251
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hemojuvelin BMP co-receptor	Mus musculus	256-259
19191760-1	2009	Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin).	Iron	122-126	hemojuvelin BMP co-receptor	Mus musculus	261-273
19366358-2	2009	We proposed that intracellular application of the parent, iron-free tetraaza[14]annulene ligand, TAA-1, as precursor would allow antioxidative defense along two lines, i.e. by chelation of potentially toxic cellular iron ions and, subsequently, by catalase-mimic activity.	Iron	58-62	PVR cell adhesion molecule	Rattus norvegicus	97-102
19352007-3	2009	Having recently established a link between HIF and the iron-regulatory hormone hepcidin, we hypothesized that HIFs, stabilized in the hypoxic intestinal epithelium, may also play critical roles in regulating intestinal iron absorption.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	79-87
19308044-5	2009	Furthermore, we observed that the NGAL-overexpressing cells tolerated increased iron levels in the culture environment, whereas the NGAL-underexpressing cells showed significant cell death after prolonged incubation in high-iron condition.	Iron	80-84	lipocalin 2	Homo sapiens	34-38
19308044-6	2009	Thus, overexpressing NGAL in colon carcinomas is an important regulatory molecule that integrates extracellular environment cues, iron metabolism, and intracellular small GTPase signaling in cancer migration and invasion.	Iron	115-119	lipocalin 2	Homo sapiens	21-25
19190544-5	2009	BDNF-III and -IV mRNAs and BDNF protein expression remained down-regulated in FID rats when compared with the always iron-sufficient rats.	Iron	117-121	brain-derived neurotrophic factor	Rattus norvegicus	0-4
19594102-1	2009	Neuroferritinopathy is an autosomal dominant basal ganglia disease with iron accumulation caused by a mutation of the gene encoding ferritin light polypeptide (FTL).	Iron	72-76	ferritin light chain	Homo sapiens	132-158
19594102-1	2009	Neuroferritinopathy is an autosomal dominant basal ganglia disease with iron accumulation caused by a mutation of the gene encoding ferritin light polypeptide (FTL).	Iron	72-76	ferritin light chain	Homo sapiens	160-163
19594102-9	2009	A mutation in exon 4 of the FTL gene is known to alter the structure of E-helices, thereby leading to the release of free iron and excessive oxidative stress.	Iron	122-126	ferritin light chain	Homo sapiens	28-31
19066337-3	2009	One example of this pleiotropy is the Izh2p-dependent repression of FET3, a gene involved in iron-uptake.	Iron	93-97	PAQR-type receptor	Saccharomyces cerevisiae S288C	38-43
19013439-0	2009	Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1.	Iron	99-103	alcohol dehydrogenase iron containing 1	Homo sapiens	136-142
19152436-4	2009	In this article, the authors discuss the role of iron supplementation in the setting of CRA in view of recent reports that have addressed this issue.	Iron	49-53	myotubularin related protein 11	Homo sapiens	88-91
19215124-0	2009	Spin glass behavior of isolated, geometrically frustrated tetrahedra of iron atoms in the intermetallic La(21)Fe(8)Sn(7)C(12).	Iron	110-112	spindlin 1	Homo sapiens	0-4
19151167-3	2009	The pathogenesis of this complication remains unknown however our novel finding of a marked elevation in fibroblast growth factor 23 (FGF23), which normalized after ceasing parenteral iron, suggests an important and previously unreported effect of iron on FGF23 homeostasis.	Iron	184-188	fibroblast growth factor 23	Homo sapiens	105-132
19151167-3	2009	The pathogenesis of this complication remains unknown however our novel finding of a marked elevation in fibroblast growth factor 23 (FGF23), which normalized after ceasing parenteral iron, suggests an important and previously unreported effect of iron on FGF23 homeostasis.	Iron	184-188	fibroblast growth factor 23	Homo sapiens	134-139
19151167-3	2009	The pathogenesis of this complication remains unknown however our novel finding of a marked elevation in fibroblast growth factor 23 (FGF23), which normalized after ceasing parenteral iron, suggests an important and previously unreported effect of iron on FGF23 homeostasis.	Iron	248-252	fibroblast growth factor 23	Homo sapiens	105-132
19151167-3	2009	The pathogenesis of this complication remains unknown however our novel finding of a marked elevation in fibroblast growth factor 23 (FGF23), which normalized after ceasing parenteral iron, suggests an important and previously unreported effect of iron on FGF23 homeostasis.	Iron	248-252	fibroblast growth factor 23	Homo sapiens	134-139
19151167-3	2009	The pathogenesis of this complication remains unknown however our novel finding of a marked elevation in fibroblast growth factor 23 (FGF23), which normalized after ceasing parenteral iron, suggests an important and previously unreported effect of iron on FGF23 homeostasis.	Iron	248-252	fibroblast growth factor 23	Homo sapiens	256-261
18955558-0	2009	Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.	Iron	74-78	STEAP family member 3	Mus musculus	20-26
19109230-5	2009	Feeding of low- or high-iron diet was associated with appropriate ferroportin 1 and hepcidin responses in mice given histocompatible T cells, whereas mice given histoincompatible T cells showed inappropriate up-regulation of duodenal ferroportin 1 and a loss of expression of hepatic hepcidin.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	84-92
19109230-5	2009	Feeding of low- or high-iron diet was associated with appropriate ferroportin 1 and hepcidin responses in mice given histocompatible T cells, whereas mice given histoincompatible T cells showed inappropriate up-regulation of duodenal ferroportin 1 and a loss of expression of hepatic hepcidin.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	284-292
19402507-1	2009	An SRB community (SRB-2) was enriched from marine sediment for the treatment of sulfate-rich wastewater of high salinity, and the effect of salinity, temperature, pH value, carbon source, concentration of sulfate and the form of Fe on the activity of SRB-2 was studied.	Iron	229-231	chaperonin containing TCP1 subunit 4	Homo sapiens	3-6
19402507-1	2009	An SRB community (SRB-2) was enriched from marine sediment for the treatment of sulfate-rich wastewater of high salinity, and the effect of salinity, temperature, pH value, carbon source, concentration of sulfate and the form of Fe on the activity of SRB-2 was studied.	Iron	229-231	chaperonin containing TCP1 subunit 4	Homo sapiens	18-21
19402507-1	2009	An SRB community (SRB-2) was enriched from marine sediment for the treatment of sulfate-rich wastewater of high salinity, and the effect of salinity, temperature, pH value, carbon source, concentration of sulfate and the form of Fe on the activity of SRB-2 was studied.	Iron	229-231	chaperonin containing TCP1 subunit 4	Homo sapiens	18-21
19402507-4	2009	Zero-valent Fe can promote the reductive activity of SRB-2, while Fe2+ inhibits that.	Iron	12-14	chaperonin containing TCP1 subunit 4	Homo sapiens	53-56
19036700-7	2009	Likewise, bilirubin, Fe chelation, and overexpression of heavy-chain ferritin all induced DAF expression in endothelial cells (EC).	Iron	21-23	CD55 molecule (Cromer blood group)	Homo sapiens	90-93
19047680-0	2009	Regulation of growth differentiation factor 15 expression by intracellular iron.	Iron	75-79	growth differentiation factor 15	Homo sapiens	14-46
19047680-3	2009	We therefore sought to characterize the regulation of GDF15 by iron and oxygen and to define the involvement or otherwise of HIF and IRP pathways.	Iron	63-67	growth differentiation factor 15	Homo sapiens	54-59
19047680-4	2009	Here we show that GDF15 is strongly up-regulated by stimuli that deplete cells of iron and that this response is specifically antagonized by the reprovision of iron.	Iron	82-86	growth differentiation factor 15	Homo sapiens	18-23
19047680-4	2009	Here we show that GDF15 is strongly up-regulated by stimuli that deplete cells of iron and that this response is specifically antagonized by the reprovision of iron.	Iron	160-164	growth differentiation factor 15	Homo sapiens	18-23
19047680-5	2009	GDF15 exhibits greater sensitivity to iron depletion than hypoxia, and responses to hypoxia and iron depletion are independent of HIF and IRP activation, suggesting a novel mechanism of regulation.	Iron	38-42	growth differentiation factor 15	Homo sapiens	0-5
19051252-1	2009	The cellular localization of DMT1 and its functional characterization suggest that DMT1 may play an important role in the physiological brain iron transport.	Iron	142-146	RoBo-1	Rattus norvegicus	29-33
19051252-1	2009	The cellular localization of DMT1 and its functional characterization suggest that DMT1 may play an important role in the physiological brain iron transport.	Iron	142-146	RoBo-1	Rattus norvegicus	83-87
19051252-2	2009	But the regulation of DMT1 expression by iron in the brain is still not clearly understood.	Iron	41-45	RoBo-1	Rattus norvegicus	22-26
19051252-6	2009	Whereas the expression of DMT1 (-IRE) decreased significantly after 7 days of ICV when ferrous iron was increased significantly.	Iron	87-99	RoBo-1	Rattus norvegicus	26-30
19051252-8	2009	The results demonstrate that DMT1 (-IRE) expression was correlated probably with brain iron levels; especially, its regulation was correlated with ferrous iron (not ferric iron) in CPu and SN in adult rats, compared with those of saline-injected control rats.	Iron	87-91	RoBo-1	Rattus norvegicus	29-33
19051252-8	2009	The results demonstrate that DMT1 (-IRE) expression was correlated probably with brain iron levels; especially, its regulation was correlated with ferrous iron (not ferric iron) in CPu and SN in adult rats, compared with those of saline-injected control rats.	Iron	147-159	RoBo-1	Rattus norvegicus	29-33
19051252-9	2009	The effect of ferrous iron on the expression of DMT1 (-IRE) in the brain also suggests that it might play a major physiological role in brain iron uptake and transport, but further studies are needed to clarify these issues.	Iron	22-26	RoBo-1	Rattus norvegicus	48-52
19051252-9	2009	The effect of ferrous iron on the expression of DMT1 (-IRE) in the brain also suggests that it might play a major physiological role in brain iron uptake and transport, but further studies are needed to clarify these issues.	Iron	142-146	RoBo-1	Rattus norvegicus	48-52
18948155-1	2009	Hepcidin, a principle regulator of iron metabolism, is synthesized by the liver.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	0-8
18948155-2	2009	Contradictory results have been reported on the regulation of hepcidin expression in response to serum transferrin saturation and liver iron content.	Iron	136-140	hepcidin antimicrobial peptide	Mus musculus	62-70
18948155-4	2009	We find that hepcidin expression correlates significantly with serum transferrin saturation, whereas there is a negative correlation of hepcidin expression with liver tissue iron level.	Iron	174-178	hepcidin antimicrobial peptide	Mus musculus	136-144
18922858-1	2009	Mice with total and constitutive iron regulatory protein 2 (IRP2) deficiency exhibit microcytosis and altered body iron distribution with duodenal and hepatic iron loading and decreased iron levels in splenic macrophages.	Iron	33-37	iron responsive element binding protein 2	Mus musculus	60-64
18922858-1	2009	Mice with total and constitutive iron regulatory protein 2 (IRP2) deficiency exhibit microcytosis and altered body iron distribution with duodenal and hepatic iron loading and decreased iron levels in splenic macrophages.	Iron	115-119	iron responsive element binding protein 2	Mus musculus	33-58
18922858-1	2009	Mice with total and constitutive iron regulatory protein 2 (IRP2) deficiency exhibit microcytosis and altered body iron distribution with duodenal and hepatic iron loading and decreased iron levels in splenic macrophages.	Iron	115-119	iron responsive element binding protein 2	Mus musculus	60-64
18922858-1	2009	Mice with total and constitutive iron regulatory protein 2 (IRP2) deficiency exhibit microcytosis and altered body iron distribution with duodenal and hepatic iron loading and decreased iron levels in splenic macrophages.	Iron	115-119	iron responsive element binding protein 2	Mus musculus	33-58
18922858-1	2009	Mice with total and constitutive iron regulatory protein 2 (IRP2) deficiency exhibit microcytosis and altered body iron distribution with duodenal and hepatic iron loading and decreased iron levels in splenic macrophages.	Iron	115-119	iron responsive element binding protein 2	Mus musculus	60-64
18997172-1	2009	Hepcidin plays a major role in the regulation of iron homeostasis.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	0-8
18997172-3	2009	Hemojuvelin, a protein critical for maintaining appropriate levels of hepcidin, acts as a coreceptor for BMP2 and BMP4, thereby providing a link between iron homeostasis and the BMP-signaling pathway.	Iron	153-157	hemojuvelin BMP co-receptor	Mus musculus	0-11
18997172-3	2009	Hemojuvelin, a protein critical for maintaining appropriate levels of hepcidin, acts as a coreceptor for BMP2 and BMP4, thereby providing a link between iron homeostasis and the BMP-signaling pathway.	Iron	153-157	hepcidin antimicrobial peptide	Mus musculus	70-78
19057509-5	2009	In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport.	Iron	159-163	mediator complex subunit 7	Homo sapiens	9-14
18952085-4	2009	METHODS: The effect of retinoids on the iron metabolism was examined in HuH7 cells treated with all-trans retinoic acid and acyclic retinoid NIK-333.	Iron	40-44	MIR7-3 host gene	Homo sapiens	72-76
18952085-6	2009	RESULTS: Hepatic iron accumulation and increased expression of hemojuvelin were observed in RAR-E Tg mouse liver.	Iron	17-21	retinoic acid receptor, alpha	Mus musculus	92-95
18952085-8	2009	Overexpression of hemojuvelin in HuH7 hepatoma cells led to a significant increase in cellular iron content.	Iron	95-99	MIR7-3 host gene	Homo sapiens	33-37
19118451-5	2009	Results indicated that deletion of the so2426 gene negatively affected expression of a small protein subset (27 proteins) including those with annotated functions in siderophore biosynthesis (SO3032), Fe uptake (SO4743), intracellular Fe storage (Bfr1), and other transport processes.	Iron	201-203	response regulator transcription factor	Shewanella oneidensis MR-1	39-45
19118451-5	2009	Results indicated that deletion of the so2426 gene negatively affected expression of a small protein subset (27 proteins) including those with annotated functions in siderophore biosynthesis (SO3032), Fe uptake (SO4743), intracellular Fe storage (Bfr1), and other transport processes.	Iron	235-237	response regulator transcription factor	Shewanella oneidensis MR-1	39-45
18983822-1	2008	Heme oxygenase (HO) is a rate-limiting step of heme degradation, which catalyzes the conversion of heme into biliverdin, iron, and CO. HO has been characterized in micro-organisms, insects, plants, and mammals.	Iron	121-125	Heme oxygenase	Drosophila melanogaster	16-18
18983822-1	2008	Heme oxygenase (HO) is a rate-limiting step of heme degradation, which catalyzes the conversion of heme into biliverdin, iron, and CO. HO has been characterized in micro-organisms, insects, plants, and mammals.	Iron	121-125	Heme oxygenase	Drosophila melanogaster	135-137
18983822-5	2008	Deficiency of the dHO protein resulted in increased levels of iron and heme in larvae.	Iron	62-66	Heme oxygenase	Drosophila melanogaster	18-21
18983822-6	2008	The accumulation of iron was also observed in the compound eyes of dHO-knockdown adult flies.	Iron	20-24	Heme oxygenase	Drosophila melanogaster	67-70
19021507-3	2008	Three distinct types of Fe-S cluster assembly machinery have been established in bacteria, termed the NIF, ISC and SUF systems, and, in each case, the overall mechanism involves cysteine desulfurase-mediated assembly of transient clusters on scaffold proteins and subsequent transfer of pre-formed clusters to apo proteins.	Iron	24-28	S100 calcium binding protein A9	Homo sapiens	102-105
18945614-6	2008	The N-hydroxypyridin-2(1H)one moiety constitutes a novel pharmacophore for the design of cyclic hydroxamic mimetics capable of chelating 5-LOX iron for exploitation in the design of 5-LOX inhibitory AI drugs.	Iron	143-147	lysyl oxidase	Homo sapiens	139-142
18945614-6	2008	The N-hydroxypyridin-2(1H)one moiety constitutes a novel pharmacophore for the design of cyclic hydroxamic mimetics capable of chelating 5-LOX iron for exploitation in the design of 5-LOX inhibitory AI drugs.	Iron	143-147	lysyl oxidase	Homo sapiens	184-187
18849539-7	2008	Moreover, when the siRNA knocked down the cellular DMT1 expression, the elevated Fe uptake caused by Mn exposure in the choroidal epithelial Z310 cells was completely abolished, indicating that Mn may facilitate Fe efflux via a DMT1-mediated transport mechanism.	Iron	81-83	RoBo-1	Rattus norvegicus	51-55
18849539-7	2008	Moreover, when the siRNA knocked down the cellular DMT1 expression, the elevated Fe uptake caused by Mn exposure in the choroidal epithelial Z310 cells was completely abolished, indicating that Mn may facilitate Fe efflux via a DMT1-mediated transport mechanism.	Iron	212-214	RoBo-1	Rattus norvegicus	51-55
18849539-9	2008	Taken together, these data suggest that free Fe appears to be favorably transported from the CSF toward the blood by DMT1 and this process can be facilitated by Mn exposure.	Iron	45-47	RoBo-1	Rattus norvegicus	117-121
18929386-6	2008	Energy dispersive X-ray analysis showed the SRB-PP contained elements such as sulphur, iron, calcium and phosphorus.	Iron	87-91	chaperonin containing TCP1 subunit 4	Homo sapiens	44-47
18784075-5	2008	In Saccharomyces cerevisiae, only monomeric yeast frataxin (Yfh1) was detected in unstressed cells when mitochondrial iron uptake was maintained at a steady, low nanomolar level.	Iron	118-122	ferroxidase	Saccharomyces cerevisiae S288C	60-64
18784075-6	2008	Increments in mitochondrial iron uptake induced stepwise assembly of Yfh1 species ranging from trimer to &gt; or = 24-mer, independent of interactions between Yfh1 and its major iron-binding partners, Isu1/Nfs1 or aconitase.	Iron	28-32	ferroxidase	Saccharomyces cerevisiae S288C	69-73
18784075-11	2008	The data suggest that Yfh1 assembly responds to dynamic changes in mitochondrial iron uptake or stress exposure in a highly controlled fashion and that this may enable frataxin to simultaneously promote respiratory function and stress tolerance.	Iron	81-85	ferroxidase	Saccharomyces cerevisiae S288C	22-26
18710911-9	2008	The effects of cryptolepine on the transcription of iron transport-related genes were consistent with a loss of function of the iron sensor Aft1p, indicating a possible disruption of iron metabolism in S. cerevisiae.	Iron	128-132	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	140-145
18710911-9	2008	The effects of cryptolepine on the transcription of iron transport-related genes were consistent with a loss of function of the iron sensor Aft1p, indicating a possible disruption of iron metabolism in S. cerevisiae.	Iron	128-132	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	140-145
18694996-0	2008	Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.	Iron	25-29	iron responsive element binding protein 2	Mus musculus	60-65
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	93-97
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	192-196
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	Snx3p	Saccharomyces cerevisiae S288C	210-214
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	Snx3p	Saccharomyces cerevisiae S288C	215-220
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	50-54	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	192-196
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	93-97
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	192-196
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	Snx3p	Saccharomyces cerevisiae S288C	210-214
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	Snx3p	Saccharomyces cerevisiae S288C	215-220
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	192-196
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	93-97
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	192-196
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	Snx3p	Saccharomyces cerevisiae S288C	210-214
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	Snx3p	Saccharomyces cerevisiae S288C	215-220
18768754-2	2008	Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded.	Iron	158-162	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	192-196
18768754-3	2008	We report that iron-induced endocytosis of Fet3-Ftr1 is independent of Fet3-Ftr1 ubiquitylation, and after endocytosis, degradation of Fet3-Ftr1 is mediated by the multivesicular body (MVB) sorting pathway.	Iron	15-19	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	48-52
18768754-5	2008	In the presence and absence of iron, Fet3-Ftr1 transits an endosomal compartment where a subunit of the MVB sorting receptor (Vps27), Snx3/Grd19, and retromer proteins colocalize.	Iron	31-35	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	42-46
18723004-4	2008	Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15.	Iron	126-130	amyloid beta precursor protein binding family B member 1	Rattus norvegicus	81-86
18723004-4	2008	Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15.	Iron	126-130	clusterin	Rattus norvegicus	94-97
18789313-7	2008	Hippocampal expression of the plasticity-related protein PKC-gamma was increased through trace fear conditioning, but reduced at P35 in the iron-deficient group.	Iron	140-144	protein kinase C, gamma	Rattus norvegicus	57-66
18789313-7	2008	Hippocampal expression of the plasticity-related protein PKC-gamma was increased through trace fear conditioning, but reduced at P35 in the iron-deficient group.	Iron	140-144	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	129-132
18815723-13	2008	Western Blot analyses revealed a long term down-regulating effect of ascorbic acid on iron independent and iron dependent Nramp2 and Dcytb expression.	Iron	107-111	cytochrome b reductase 1	Homo sapiens	133-138
18815723-20	2008	Similarly, the short term up-regulation of Nramp2 and Dcytb seems to agree with the improvement in iron uptake shown in humans when single doses of ascorbic acid were administrated.	Iron	99-103	cytochrome b reductase 1	Homo sapiens	54-59
19209525-10	2008	The possible participation of ferric reductase activity Dcytb in transferrin cycle in liver and in neutrophil host defense implies new aspects of the role of vitamin C in the regulation of iron homeostasis.	Iron	189-193	cytochrome b reductase 1	Homo sapiens	56-61
18603562-12	2008	CONCLUSIONS: The findings of this study suggest that the observed TMPRSS6 mutation leads to overproduction of hepcidin and, in turn, to defective iron absorption and utilization.	Iron	146-150	hepcidin antimicrobial peptide	Mus musculus	110-118
18845707-7	2008	RESULTS: Relative to non-consumers, bean consumers had higher intakes of dietary fiber, potassium, magnesium, iron, and copper (p"s &lt; 0.05).	Iron	110-114	brain expressed associated with NEDD4 1	Homo sapiens	36-40
18982432-3	2008	The NADH oxidation domain harbouring the FMN cofactor is connected via a chain of iron-sulfur clusters to the ubiquinone reduction site that is located in a large pocket formed by the PSST- and 49-kDa subunits of complex I.	Iron	82-86	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	184-188
18703840-1	2008	Yeast glutaredoxin 3 (Grx3) is a cytosolic protein that regulates the activity of the iron-responsive transcriptional activator Aft1.	Iron	86-90	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	128-132
18725016-3	2008	The increase in NGAL production and release from tubular cells after harmful stimuli of various kinds may have self-defensive intent based on the activation of specific iron-dependent pathways, which in all probability also represent the mechanism through which NGAL promotes kidney growth and differentiation.	Iron	169-173	lipocalin 2	Homo sapiens	16-20
18725016-3	2008	The increase in NGAL production and release from tubular cells after harmful stimuli of various kinds may have self-defensive intent based on the activation of specific iron-dependent pathways, which in all probability also represent the mechanism through which NGAL promotes kidney growth and differentiation.	Iron	169-173	lipocalin 2	Homo sapiens	262-266
18685102-0	2008	Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.	Iron	37-41	iron responsive element binding protein 2	Mus musculus	120-124
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	58-62	aconitase 1	Mus musculus	99-103
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	58-62	aconitase 1	Mus musculus	108-112
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	58-62	iron responsive element binding protein 2	Mus musculus	118-143
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	58-62	iron responsive element binding protein 2	Mus musculus	159-163
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	58-62	iron responsive element binding protein 2	Mus musculus	168-173
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	aconitase 1	Mus musculus	58-83
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	aconitase 1	Mus musculus	99-103
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	aconitase 1	Mus musculus	108-112
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	iron responsive element binding protein 2	Mus musculus	159-163
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	iron responsive element binding protein 2	Mus musculus	168-173
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	aconitase 1	Mus musculus	58-83
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	aconitase 1	Mus musculus	99-103
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	aconitase 1	Mus musculus	108-112
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	iron responsive element binding protein 2	Mus musculus	159-163
18685102-1	2008	In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts.	Iron	118-122	iron responsive element binding protein 2	Mus musculus	168-173
18685102-2	2008	Mice that lack IRP2 develop microcytic anemia and neurodegeneration associated with functional cellular iron depletion caused by low TfR1 and high ferritin expression.	Iron	104-108	iron responsive element binding protein 2	Mus musculus	15-19
18539898-0	2008	Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.	Iron	0-4	inhibitor of DNA binding 1, HLH protein	Mus musculus	80-83
18539898-3	2008	Among 1419 transcripts significantly modulated by the dietary iron content, 4 were regulated similarly to the hepcidin genes Hamp1 and Hamp2.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	110-118
18539898-3	2008	Among 1419 transcripts significantly modulated by the dietary iron content, 4 were regulated similarly to the hepcidin genes Hamp1 and Hamp2.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	125-130
18539898-8	2008	However, as shown by analysis of mice with liver-specific disruption of Smad4, activation of Smad7, Id1, and Atoh8 transcription by iron requires Smad4.	Iron	132-136	inhibitor of DNA binding 1, HLH protein	Mus musculus	100-103
18684963-4	2008	The macrophage iron exporter ferroportin (FPN) was up-regulated in the Hfe(-/-) mice, and correspondingly, intramacrophage iron levels were lowered.	Iron	15-19	homeostatic iron regulator	Mus musculus	71-74
18538129-4	2008	Upregulation of JMJD1A mRNA and protein in cultured human cells exposed to hypoxia or iron scavengers in vitro was abrogated when hypoxia-inducible factor-1 (HIF-1) signaling was blocked by siRNAs.	Iron	86-90	lysine demethylase 3A	Homo sapiens	16-22
18538129-5	2008	A single pivotal hypoxia responsive element (HRE) in the promoter of the human JMJD1A gene was identified that mediates JMJD1A upregulation by hypoxia, iron scavengers, and HIF-1.	Iron	152-156	lysine demethylase 3A	Homo sapiens	79-85
18538129-5	2008	A single pivotal hypoxia responsive element (HRE) in the promoter of the human JMJD1A gene was identified that mediates JMJD1A upregulation by hypoxia, iron scavengers, and HIF-1.	Iron	152-156	lysine demethylase 3A	Homo sapiens	120-126
18583042-8	2008	Copper (Cu(2+), 50-100 microM) and manganese (Mn(2+), 50-100 microM) potently increased the expression of both APP and BACE1 in a time- and concentration-dependent pattern, while zinc (Zn(2+)), iron (Fe(2+)) and aluminum (Al(3+)) did not.	Iron	194-198	beta-secretase 1	Rattus norvegicus	119-124
18583042-8	2008	Copper (Cu(2+), 50-100 microM) and manganese (Mn(2+), 50-100 microM) potently increased the expression of both APP and BACE1 in a time- and concentration-dependent pattern, while zinc (Zn(2+)), iron (Fe(2+)) and aluminum (Al(3+)) did not.	Iron	200-202	beta-secretase 1	Rattus norvegicus	119-124
18583042-12	2008	These results suggest that these irons cause differential effects on the expression of APP and BACE1 in PC12 cells, and curcumin can significantly reverse their effects.	Iron	33-38	beta-secretase 1	Rattus norvegicus	95-100
18647837-4	2008	Chloroplasts prepared from fro7 loss-of-function mutants have 75% less Fe(III) chelate reductase activity and contain 33% less iron per microgram of chlorophyll than wild-type chloroplasts.	Iron	127-131	ferric reduction oxidase 7	Arabidopsis thaliana	27-31
18647837-6	2008	When germinated in alkaline soil, fro7 seedlings show severe chlorosis and die without setting seed unless watered with high levels of soluble iron.	Iron	143-147	ferric reduction oxidase 7	Arabidopsis thaliana	34-38
18647837-7	2008	Overall, our results provide molecular evidence that FRO7 plays a role in chloroplast iron acquisition and is required for efficient photosynthesis in young seedlings and for survival under iron-limiting conditions.	Iron	86-90	ferric reduction oxidase 7	Arabidopsis thaliana	53-57
18647837-7	2008	Overall, our results provide molecular evidence that FRO7 plays a role in chloroplast iron acquisition and is required for efficient photosynthesis in young seedlings and for survival under iron-limiting conditions.	Iron	190-194	ferric reduction oxidase 7	Arabidopsis thaliana	53-57
18764291-4	2008	Our work indicates that to determine the magnitude and the absolute direction of FE polarization in spin-spiral states, it is crucial to consider the displacements of the ions from their centrosymmetric positions.	Iron	81-83	spindlin 1	Homo sapiens	100-104
18191891-6	2008	The proposed method has been applied to the tap water and Ankara Creek water in order to Fe, Cr, and Ni remediation and preconcentration.	Iron	89-91	nuclear RNA export factor 1	Homo sapiens	44-47
18420243-1	2008	Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier.	Iron	78-82	RoBo-1	Rattus norvegicus	167-195
18540637-3	2008	Cellular production of Fe-S clusters is accomplished by the Fe cofactor assembly platform enzymes Isu (eukaryotes) and IscU (prokaryotes).	Iron	23-27	Iron-sulfur cluster assembly enzyme	Drosophila melanogaster	119-123
18540637-3	2008	Cellular production of Fe-S clusters is accomplished by the Fe cofactor assembly platform enzymes Isu (eukaryotes) and IscU (prokaryotes).	Iron	23-25	Iron-sulfur cluster assembly enzyme	Drosophila melanogaster	119-123
18467329-0	2008	Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus aureus.	Iron	56-60	hemoglobin subunit gamma 2	Homo sapiens	35-48
18413491-8	2008	Furthermore, FE(Na) was lower in AAC carriers than in noncarriers (-0.082%; P=0.019).	Iron	13-15	glycine-N-acyltransferase	Homo sapiens	33-36
18492824-0	2008	Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells.	Iron	44-48	cytochrome b reductase 1	Homo sapiens	0-21
18492824-5	2008	Iron uptake (59Fe) was significantly higher in Dcytb-transfected Caco-2 cells than in cells transfected with empty vector as a control.	Iron	0-4	cytochrome b reductase 1	Homo sapiens	47-52
18492824-9	2008	Cotransfection of Dcytb and DMT1 resulted in an additive increase in iron uptake by the cells.	Iron	69-73	cytochrome b reductase 1	Homo sapiens	18-23
18492824-10	2008	The results confirm Dcytb can act as a ferric reductase that stimulates iron uptake in Caco-2 cells.	Iron	72-76	cytochrome b reductase 1	Homo sapiens	20-25
17936676-0	2008	Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous carcinoma cells.	Iron	0-4	matrix metallopeptidase 9	Homo sapiens	15-20
17936676-4	2008	However, the effect of iron on MMP-9 expression in HNSCC has not been studied.	Iron	23-27	matrix metallopeptidase 9	Homo sapiens	31-36
17936676-5	2008	In the present study, we examined the effect of iron on MMP-9 expression in head and neck squamous carcinoma cell lines (OM-2 and HN-22).	Iron	48-52	matrix metallopeptidase 9	Homo sapiens	56-61
18509548-0	2008	The protective role of transferrin in Muller glial cells after iron-induced toxicity.	Iron	63-67	transferrin	Mus musculus	23-34
18481019-5	2008	The pre-treatment of rats with FE, however, suppressed the increment of levels of GOT, GPT, ALP, LDH and MDA, as well as recovered the levels of SOD, CAT and GPx in CCl(4)-treated rats.	Iron	31-33	glutamic--pyruvic transaminase	Rattus norvegicus	87-90
18262302-6	2008	Furthermore, the levels of total iron and labile iron pool (LIP) were altered in Huh7-HBx.	Iron	33-37	MIR7-3 host gene	Homo sapiens	81-85
18262302-6	2008	Furthermore, the levels of total iron and labile iron pool (LIP) were altered in Huh7-HBx.	Iron	49-53	MIR7-3 host gene	Homo sapiens	81-85
18258594-7	2008	Notably, only Fe(3+)-induced oligomers were SDS-resistant and could form ion-permeable pores in a planar lipid bilayer, which were inhibited by the oligomer-specific A11 antibody.	Iron	14-16	immunoglobulin kappa variable 3D-20	Homo sapiens	166-169
18022819-4	2008	Ceruloplasmin (Cp) is the major multicopper ferroxidase in blood; however, hephaestin (Hp), a membrane-bound Cp homolog, was recently discovered and has been implicated in the export of iron from duodenal enterocytes into blood.	Iron	186-190	hephaestin	Homo sapiens	75-85
18042040-1	2008	Hepcidin is a hormone central to the regulation of iron homeostasis in the body.	Iron	51-55	hepcidin antimicrobial peptide	Mus musculus	0-8
18042040-3	2008	Ferroportin, an iron exporter, is the receptor for hepcidin.	Iron	16-20	hepcidin antimicrobial peptide	Mus musculus	51-59
18042040-12	2008	We conclude that retinal iron homeostasis may be regulated in an autonomous manner by hepcidin generated within the retina and that chronic bacterial infection/inflammation of the retina may disrupt iron homeostasis and retinal function.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	86-94
18212074-3	2008	Here we show that while OpR and TrR strains both produce three-dimensional biofilm structures that are indicative of rugose extracellular polysaccharide (rEPS) production, OpR strains also retain expression of CPS and are virulent in an iron-supplemented mouse model, while TrR strains lack CPS and are avirulent.	Iron	237-241	zinc finger protein of the cerebellum 5	Mus musculus	24-27
18340635-5	2008	In hearts from frataxin KO mice, components of the iron-dependent complex-I and -II of the mitochondrial electron transport chain and enzymes involved in ATP homeostasis (creatine kinase, adenylate kinase) displayed decreased expression.	Iron	51-55	frataxin	Mus musculus	15-23
18194661-0	2008	Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism.	Iron	101-105	cytochrome b reductase 1	Homo sapiens	37-58
18194661-0	2008	Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism.	Iron	101-105	cytochrome b reductase 1	Homo sapiens	60-66
18194661-1	2008	Duodenal cytochrome b (Dcytb or Cybrd1) is an iron-regulated protein, highly expressed in the duodenal brush border membrane.	Iron	46-50	cytochrome b reductase 1	Homo sapiens	0-21
18194661-1	2008	Duodenal cytochrome b (Dcytb or Cybrd1) is an iron-regulated protein, highly expressed in the duodenal brush border membrane.	Iron	46-50	cytochrome b reductase 1	Homo sapiens	23-28
18194661-1	2008	Duodenal cytochrome b (Dcytb or Cybrd1) is an iron-regulated protein, highly expressed in the duodenal brush border membrane.	Iron	46-50	cytochrome b reductase 1	Homo sapiens	32-38
18316026-2	2008	We developed mutant mouse strains to gain insight into the role of the Hfe/Tfr1 complex in regulating iron homeostasis.	Iron	102-106	homeostatic iron regulator	Mus musculus	71-74
18316026-4	2008	Under conditions favoring a constitutive Hfe/Tfr1 interaction, mice developed iron overload attributable to inappropriately low expression of the hormone hepcidin.	Iron	78-82	homeostatic iron regulator	Mus musculus	41-44
18316026-4	2008	Under conditions favoring a constitutive Hfe/Tfr1 interaction, mice developed iron overload attributable to inappropriately low expression of the hormone hepcidin.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	154-162
18268542-8	2008	Overexpression of FIT with either AtbHLH38 or AtbHLH39 in plants converted the expression of the iron uptake genes FRO2 and IRT1 from induced to constitutive.	Iron	97-101	iron-regulated transporter 1	Arabidopsis thaliana	124-128
18317567-3	2008	Although the cytosol contained excess iron, Hfe(-/-) mitochondria contained normal iron but decreased copper, manganese, and zinc, associated with reduced activities of copper-dependent cytochrome c oxidase and manganese-dependent superoxide dismutase (MnSOD).	Iron	83-87	homeostatic iron regulator	Mus musculus	44-47
18029550-4	2008	Incubation of cells with doxorubicin (DOX) up-regulated mRNA levels of the iron-regulated genes transferrin receptor-1 (TfR1) and N-myc downstream-regulated gene-1 (Ndrg1).	Iron	75-79	N-myc downstream regulated 1	Homo sapiens	130-163
18029550-4	2008	Incubation of cells with doxorubicin (DOX) up-regulated mRNA levels of the iron-regulated genes transferrin receptor-1 (TfR1) and N-myc downstream-regulated gene-1 (Ndrg1).	Iron	75-79	N-myc downstream regulated 1	Homo sapiens	165-170
18160403-4	2008	FTL and FTH are regulated primarily at a post-transcriptional level in response to cellular iron concentrations.	Iron	92-96	ferritin light chain	Homo sapiens	0-3
18258918-7	2008	We further demonstrate that FLVCR mediates heme export from macrophages that ingest senescent red cells and regulates hepatic iron.	Iron	126-130	FLVCR heme transporter 1	Homo sapiens	28-33
18249176-4	2008	This work demonstrates that local Hfe expression in hepatocytes serves to maintain physiological iron homeostasis, answering a long-standing question in medicine and explaining earlier clinical observations.	Iron	97-101	homeostatic iron regulator	Mus musculus	34-37
18190467-7	2008	CHr were distributed with 33.7 +/- 1.4 pg in the iron sufficient group and with 29.9 +/- 1.9 pg in the iron deficient group (P = 0.001).	Iron	49-53	chromate resistance; sulfate transport	Homo sapiens	0-3
18190467-7	2008	CHr were distributed with 33.7 +/- 1.4 pg in the iron sufficient group and with 29.9 +/- 1.9 pg in the iron deficient group (P = 0.001).	Iron	103-107	chromate resistance; sulfate transport	Homo sapiens	0-3
18190467-9	2008	In iron deficient patients, a significant correlation was found between CHr and TS.	Iron	3-7	chromate resistance; sulfate transport	Homo sapiens	72-75
18083267-0	2008	Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron.	Iron	86-90	transferrin receptor protein 2	Cricetulus griseus	0-22
18083267-1	2008	BACKGROUND/AIMS: Transferrin receptor 2 appears to have dual roles in iron metabolism; one is signalling, the other is iron transport.	Iron	70-74	transferrin receptor protein 2	Cricetulus griseus	17-39
18083267-1	2008	BACKGROUND/AIMS: Transferrin receptor 2 appears to have dual roles in iron metabolism; one is signalling, the other is iron transport.	Iron	119-123	transferrin receptor protein 2	Cricetulus griseus	17-39
18083267-4	2008	This study sought to clarify the role of transferrin receptor 2 in the uptake of transferrin-bound and non-transferrin-bound iron.	Iron	125-129	transferrin receptor protein 2	Cricetulus griseus	41-63
18083267-7	2008	RESULTS: Cells expressing transferrin receptor 2 bound and internalised transferrin and transferrin-bound iron.	Iron	106-110	transferrin receptor protein 2	Cricetulus griseus	26-48
18083267-9	2008	Interestingly, the presence of transferrin receptor 2 was also associated with uptake of non-transferrin-bound iron which was inhibited by unlabelled transferrin-bound metals.	Iron	111-115	transferrin receptor protein 2	Cricetulus griseus	31-53
18083267-11	2008	CONCLUSIONS: Transferrin receptor 2 mediates transferrin-bound iron uptake by receptor-mediated endocytosis.	Iron	63-67	transferrin receptor protein 2	Cricetulus griseus	13-35
17947394-9	2008	Given the spatial relationship, we propose that the Hb scavenger receptor CD163 and HCP-1 constitute a linked pathway for Hb catabolism and heme-iron recycling in human macrophages.	Iron	145-149	CD163 molecule	Homo sapiens	74-79
18070921-1	2008	The transporter Ccc1 imports iron into the vacuole, which is the major site of iron storage in fungi and plants.	Iron	29-33	Ccc1p	Saccharomyces cerevisiae S288C	16-20
18070921-1	2008	The transporter Ccc1 imports iron into the vacuole, which is the major site of iron storage in fungi and plants.	Iron	79-83	Ccc1p	Saccharomyces cerevisiae S288C	16-20
18070921-2	2008	CCC1 mRNA is destabilized under low-iron conditions by the binding of Cth1 and Cth2 to the 3" untranslated region (S. Puig, E. Askeland, and D. J. Thiele, Cell 120:99-110, 2005).	Iron	36-40	Ccc1p	Saccharomyces cerevisiae S288C	0-4
18070921-3	2008	Here, we show that the transcription of CCC1 is stimulated by iron through a Yap consensus site in the CCC1 promoter.	Iron	62-66	Ccc1p	Saccharomyces cerevisiae S288C	40-44
18070921-3	2008	Here, we show that the transcription of CCC1 is stimulated by iron through a Yap consensus site in the CCC1 promoter.	Iron	62-66	Ccc1p	Saccharomyces cerevisiae S288C	103-107
18067328-4	2008	Controlling the redox state of lipoxygenase iron with small molecules, inhibitors or activators, could be a means to modulate the activity of the enzyme.	Iron	44-48	linoleate 9S-lipoxygenase-4	Glycine max	31-43
18067328-10	2008	Oxidation of the iron in lipoxygenase-1 by 2-hydroperoxyalkanes was evident in electron paramagnetic resonance (EPR) measurements, but the enzyme was neither activated nor was it inactivated.	Iron	17-21	linoleate 9S-lipoxygenase-4	Glycine max	25-37
18171923-2	2008	The finding that mutations in the ferritin light polypeptide (FTL) gene cause a neurodegenerative disease known as neuroferritinopathy or hereditary ferritinopathy (HF) provided a direct connection between abnormal brain iron storage and neurodegeneration.	Iron	221-225	ferritin light polypeptide 1	Mus musculus	34-60
18171923-2	2008	The finding that mutations in the ferritin light polypeptide (FTL) gene cause a neurodegenerative disease known as neuroferritinopathy or hereditary ferritinopathy (HF) provided a direct connection between abnormal brain iron storage and neurodegeneration.	Iron	221-225	ferritin light polypeptide 1	Mus musculus	62-65
18473833-11	2008	Particularly, mutations of cytochrome b gene of ETC or changes in iron homeostasis by mitochondrial enzyme aconitase alter sensitivity of MDR1 and regulate resistance level to anti-parasitic drugs.	Iron	66-70	mitochondrially encoded cytochrome b	Homo sapiens	27-39
18166355-0	2008	Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	95-103
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	22-26	transferrin	Mus musculus	85-96
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	22-26	transferrin	Mus musculus	98-100
18926297-8	2008	For genes involved in iron processing we found an increase of ferroportin-1 (FPN-1), transferrin (Tf) and ceruloplasmin (CP) only in the acute phase, suggesting that export of iron is hampered in the chronic phase of infection.	Iron	176-180	transferrin	Mus musculus	85-96
17614955-0	2008	Subcellular location of heme oxygenase 1 and 2 and divalent metal transporter 1 in relation to endocytotic markers during heme iron absorption.	Iron	127-131	heme oxygenase 1	Rattus norvegicus	24-46
17614955-0	2008	Subcellular location of heme oxygenase 1 and 2 and divalent metal transporter 1 in relation to endocytotic markers during heme iron absorption.	Iron	127-131	RoBo-1	Rattus norvegicus	51-79
17614955-3	2008	This would require the translocation of HO-1 or HO-2 to endosomes and/or lysosomes and the presence of a transporter, possibly divalent metal transporter 1 (DMT1), to transfer released iron to the cytoplasm.	Iron	185-189	RoBo-1	Rattus norvegicus	127-155
17614955-3	2008	This would require the translocation of HO-1 or HO-2 to endosomes and/or lysosomes and the presence of a transporter, possibly divalent metal transporter 1 (DMT1), to transfer released iron to the cytoplasm.	Iron	185-189	RoBo-1	Rattus norvegicus	157-161
17614955-9	2008	DMT1 staining was markedly reduced by ferrous iron, but not heme and did not exhibit colocalization with endocytotic markers.	Iron	46-50	RoBo-1	Rattus norvegicus	0-4
17982471-8	2008	The levels of free iron in the liver were significantly increased at 4 and 8 h after onset of endotoxic shock, which did not coincide with the decrease of transferrin iron levels in the blood, but rather with expression of the inducible form of heme oxygenase (HO-1).	Iron	19-23	heme oxygenase 1	Rattus norvegicus	261-265
17982471-12	2008	Our data suggest that free iron released by HO-1 causes mitochondrial dysfunction in pathological situations accompanied by endotoxic shock.	Iron	27-31	heme oxygenase 1	Rattus norvegicus	44-48
18291005-9	2008	This may be supported by our previous observations that the effect of Hp22 was independent of markers of iron status and zinc protoporphyrin measured at the cross-sectional surveys and therefore also of iron availability for erythropoiesis.	Iron	105-109	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	70-74
18291005-9	2008	This may be supported by our previous observations that the effect of Hp22 was independent of markers of iron status and zinc protoporphyrin measured at the cross-sectional surveys and therefore also of iron availability for erythropoiesis.	Iron	203-207	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	70-74
18957753-8	2008	Some SRB group-specific primers-amplification products were obtained inside the wood and around iron.	Iron	96-100	chaperonin containing TCP1 subunit 4	Homo sapiens	5-8
18044970-0	2007	Heme synthase (ferrochelatase) catalyzes the removal of iron from heme and demetalation of metalloporphyrins.	Iron	56-60	ferrochelatase	Homo sapiens	0-13
18044970-0	2007	Heme synthase (ferrochelatase) catalyzes the removal of iron from heme and demetalation of metalloporphyrins.	Iron	56-60	ferrochelatase	Homo sapiens	15-29
18044970-5	2007	Purification of the iron-removal enzyme showed that it was identical to ferrochelatase.	Iron	20-24	ferrochelatase	Homo sapiens	72-86
18044970-6	2007	Recombinant ferrochelatase in combination with NADH-cytochrome b5 reductase catalyzed NADH-dependent iron-removal reaction from hemin and hemoproteins.	Iron	101-105	ferrochelatase	Homo sapiens	12-26
18048325-0	2007	Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC.	Iron	57-61	thiaminC	Arabidopsis thaliana	86-90
17763462-1	2007	UNLABELLED: Alcohol reduces and iron increases liver hepcidin synthesis.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	53-61
17763462-2	2007	This study investigates the interaction of alcohol and iron in the regulation of hepcidin messenger RNA (mRNA) expression in animal models.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	81-89
17763462-7	2007	Iron elevated and alcohol decreased liver hepcidin expression in mice and rats.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	42-50
17763462-13	2007	CONCLUSION: Alcohol abolishes the iron-induced up-regulation of both liver hepcidin transcription and the DNA-binding activity of C/EBP alpha.	Iron	34-38	hepcidin antimicrobial peptide	Mus musculus	75-83
17763462-14	2007	Of note, hepcidin protects the body from the harmful effects of iron overload.	Iron	64-68	hepcidin antimicrobial peptide	Mus musculus	9-17
17597094-6	2007	Together, these results demonstrate that in mammals, Fxn and mitochondria play a cardinal role in the maturation of extramitochondrial Fe-S proteins.	Iron	135-139	frataxin	Mus musculus	53-56
17918825-0	2007	Thermally induced two-step, two-site incomplete 6A1&lt;--&gt;2T2 crossover in a mononuclear iron(III) phenolate-pyridyl Schiff-base complex: a rare crystallographic observation of the coexistence of pure S=5/2 and 1/2 metal centers in the asymmetric unit.	Iron	92-96	ribosomal protein S5	Homo sapiens	204-215
17711525-1	2007	Erythropoietic protoporphyria (EPP) is an inherited disorder of haem biosynthesis caused by decreased activity of the enzyme ferrochelatase (FECH), which catalyses the insertion of iron into protoporphyrin, the last step in haem biosynthesis.	Iron	181-185	ferrochelatase	Homo sapiens	125-139
17711525-1	2007	Erythropoietic protoporphyria (EPP) is an inherited disorder of haem biosynthesis caused by decreased activity of the enzyme ferrochelatase (FECH), which catalyses the insertion of iron into protoporphyrin, the last step in haem biosynthesis.	Iron	181-185	ferrochelatase	Homo sapiens	141-145
17965933-17	2007	(4) Findings of our study suggest that 7-nitroindazole may have neuroprotective effects against iron-induced hippocampal neurotoxicity by inhibiting nNOS.	Iron	96-100	nitric oxide synthase 1	Rattus norvegicus	149-153
17848680-1	2007	PURPOSE: To prospectively determine the cellular iron uptake by using R2 and R2* mapping with multiecho readout gradient-echo and spin-echo sequences.	Iron	49-53	ribonucleotide reductase M2	Mus musculus	70-79
17848680-9	2007	R2 and R2* values were linearly correlated with cellular iron load, number of iron-loaded cells, and content of freely dissolved iron (r(2) range, 0.92-0.99; P &lt; .001).	Iron	57-61	ribonucleotide reductase M2	Mus musculus	0-9
17848680-9	2007	R2 and R2* values were linearly correlated with cellular iron load, number of iron-loaded cells, and content of freely dissolved iron (r(2) range, 0.92-0.99; P &lt; .001).	Iron	78-82	ribonucleotide reductase M2	Mus musculus	0-9
17848680-9	2007	R2 and R2* values were linearly correlated with cellular iron load, number of iron-loaded cells, and content of freely dissolved iron (r(2) range, 0.92-0.99; P &lt; .001).	Iron	78-82	ribonucleotide reductase M2	Mus musculus	0-9
17848680-13	2007	CONCLUSION: Quantitative R2 and R2* mapping enables noninvasive estimations of cellular iron load and number of iron-labeled cells.	Iron	88-92	ribonucleotide reductase M2	Mus musculus	25-34
17848680-13	2007	CONCLUSION: Quantitative R2 and R2* mapping enables noninvasive estimations of cellular iron load and number of iron-labeled cells.	Iron	112-116	ribonucleotide reductase M2	Mus musculus	25-34
17601488-2	2007	The expression of the AnCLCA cDNA restored the iron-limited growth of the Saccharomyces cerevisiae CLC null mutant strain (gef1) suggesting that AnCLCA functions as a chloride channel.	Iron	47-51	Gef1p	Saccharomyces cerevisiae S288C	24-27
17601488-2	2007	The expression of the AnCLCA cDNA restored the iron-limited growth of the Saccharomyces cerevisiae CLC null mutant strain (gef1) suggesting that AnCLCA functions as a chloride channel.	Iron	47-51	Gef1p	Saccharomyces cerevisiae S288C	123-127
17877614-2	2007	MATERIAL AND METHODS: Antiproliferative effects of orally active tridentate iron chelator ICL670 (deferasirox) and bidentate iron chelator CP20 (deferiprone), mediated through the chelation of intracellular iron, were compared in rat hepatoma cell line FAO and human hepatoma cell line HUH7.	Iron	125-129	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	139-143
17877614-2	2007	MATERIAL AND METHODS: Antiproliferative effects of orally active tridentate iron chelator ICL670 (deferasirox) and bidentate iron chelator CP20 (deferiprone), mediated through the chelation of intracellular iron, were compared in rat hepatoma cell line FAO and human hepatoma cell line HUH7.	Iron	125-129	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	139-143
17877614-3	2007	RESULTS: In FAO cell cultures, we have shown that ICL670 decreased cell viability and DNA replication and induced apoptosis more efficiently than an iron-binding equivalent concentration of CP20.	Iron	149-153	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	190-194
17877614-5	2007	In the HUH7 cell cultures, ICL670 and a four-time higher iron-binding equivalent concentration of CP20, decreased cell viability and DNA replication in the same range.	Iron	57-61	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	98-102
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	55-59
17660359-6	2007	The 5" flanking untranscribed sequences from the FEA1, FTR1, and FOX1 genes confer iron deficiency-dependent expression of ARS2, suggesting that the iron assimilation pathway is under transcriptional control by iron nutrition.	Iron	149-153	uncharacterized protein	Chlamydomonas reinhardtii	123-127
17711875-0	2007	A novel Fe deficiency-responsive element (FeRE) regulates the expression of atx1 in Chlamydomonas reinharditii.	Iron	8-10	antioxidant 1 copper chaperone	Homo sapiens	76-80
17681937-2	2007	In this report we quantify the import-export balance in the vacuole because of the import of iron by Ccc1p and to export by the combined activity of Smf3p and the ferroxidase, permease pair of proteins, Fet5p and Fth1p.	Iron	93-97	Ccc1p	Saccharomyces cerevisiae S288C	101-106
17681937-2	2007	In this report we quantify the import-export balance in the vacuole because of the import of iron by Ccc1p and to export by the combined activity of Smf3p and the ferroxidase, permease pair of proteins, Fet5p and Fth1p.	Iron	93-97	ferroxidase	Saccharomyces cerevisiae S288C	163-174
17681937-2	2007	In this report we quantify the import-export balance in the vacuole because of the import of iron by Ccc1p and to export by the combined activity of Smf3p and the ferroxidase, permease pair of proteins, Fet5p and Fth1p.	Iron	93-97	ferroxidase FET5	Saccharomyces cerevisiae S288C	203-208
17681937-2	2007	In this report we quantify the import-export balance in the vacuole because of the import of iron by Ccc1p and to export by the combined activity of Smf3p and the ferroxidase, permease pair of proteins, Fet5p and Fth1p.	Iron	93-97	Fth1p	Saccharomyces cerevisiae S288C	213-218
17640977-1	2007	Divalent metal transporter-1 (DMT1) mediates dietary nonheme iron absorption.	Iron	61-65	RoBo-1	Rattus norvegicus	0-28
17640977-1	2007	Divalent metal transporter-1 (DMT1) mediates dietary nonheme iron absorption.	Iron	61-65	RoBo-1	Rattus norvegicus	30-34
17640977-2	2007	Belgrade (b) rats have defective iron metabolism due to a mutation in the DMT1 gene.	Iron	33-37	RoBo-1	Rattus norvegicus	74-78
17640977-7	2007	Blood (59)Fe levels measured 5 min to 4 h postgavage were significantly lower in b/b rats, consistent with impaired DMT1 function in intestinal iron absorption.	Iron	144-148	RoBo-1	Rattus norvegicus	116-120
17592720-1	2007	The ferroxidase Fet3 and the permease Ftr1 constitute a well-conserved high-affinity iron uptake system in yeast.	Iron	85-89	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	38-42
17590401-7	2007	Iron loading resulted in striking increases in mRNAs for Hsp32 (heme oxygenase-1; 12-fold increase vs. controls) and metallothionein-1 and -2 (both increased approximately 6-fold).	Iron	0-4	heme oxygenase 1	Rattus norvegicus	57-62
17590401-7	2007	Iron loading resulted in striking increases in mRNAs for Hsp32 (heme oxygenase-1; 12-fold increase vs. controls) and metallothionein-1 and -2 (both increased approximately 6-fold).	Iron	0-4	heme oxygenase 1	Rattus norvegicus	64-80
17511619-1	2007	In a search for genes that modify iron homoeostasis, a gene (1300017J02Rik) was located immediately upstream of the murine TF (transferrin) gene.	Iron	34-38	transferrin	Mus musculus	123-125
17511619-1	2007	In a search for genes that modify iron homoeostasis, a gene (1300017J02Rik) was located immediately upstream of the murine TF (transferrin) gene.	Iron	34-38	transferrin	Mus musculus	127-138
17459943-3	2007	Ferritin consists of H- and L-subunits, and we demonstrated iron uptake by ferritin into multiple organs and that the uptake of iron is greater when the iron is delivered via H-ferritin compared with L-ferritin.	Iron	128-132	ferritin heavy polypeptide 1	Mus musculus	175-185
17459943-3	2007	Ferritin consists of H- and L-subunits, and we demonstrated iron uptake by ferritin into multiple organs and that the uptake of iron is greater when the iron is delivered via H-ferritin compared with L-ferritin.	Iron	128-132	ferritin heavy polypeptide 1	Mus musculus	175-185
17459943-4	2007	The delivery of iron via H-ferritin but not L-ferritin was significantly decreased in mice with compromised iron storage compared with control, indicating that a feedback mechanism exists for H-ferritin iron delivery.	Iron	16-20	ferritin heavy polypeptide 1	Mus musculus	25-35
17459943-4	2007	The delivery of iron via H-ferritin but not L-ferritin was significantly decreased in mice with compromised iron storage compared with control, indicating that a feedback mechanism exists for H-ferritin iron delivery.	Iron	16-20	ferritin heavy polypeptide 1	Mus musculus	192-202
17459943-4	2007	The delivery of iron via H-ferritin but not L-ferritin was significantly decreased in mice with compromised iron storage compared with control, indicating that a feedback mechanism exists for H-ferritin iron delivery.	Iron	108-112	ferritin heavy polypeptide 1	Mus musculus	25-35
17459943-4	2007	The delivery of iron via H-ferritin but not L-ferritin was significantly decreased in mice with compromised iron storage compared with control, indicating that a feedback mechanism exists for H-ferritin iron delivery.	Iron	108-112	ferritin heavy polypeptide 1	Mus musculus	192-202
17459943-4	2007	The delivery of iron via H-ferritin but not L-ferritin was significantly decreased in mice with compromised iron storage compared with control, indicating that a feedback mechanism exists for H-ferritin iron delivery.	Iron	108-112	ferritin heavy polypeptide 1	Mus musculus	25-35
17459943-4	2007	The delivery of iron via H-ferritin but not L-ferritin was significantly decreased in mice with compromised iron storage compared with control, indicating that a feedback mechanism exists for H-ferritin iron delivery.	Iron	108-112	ferritin heavy polypeptide 1	Mus musculus	192-202
17459943-7	2007	These studies identify H-ferritin as an iron transport protein and suggest the presence of an H-ferritin receptor for mediating iron delivery.	Iron	40-44	ferritin heavy polypeptide 1	Mus musculus	23-33
17459943-7	2007	These studies identify H-ferritin as an iron transport protein and suggest the presence of an H-ferritin receptor for mediating iron delivery.	Iron	128-132	ferritin heavy polypeptide 1	Mus musculus	23-33
17459943-7	2007	These studies identify H-ferritin as an iron transport protein and suggest the presence of an H-ferritin receptor for mediating iron delivery.	Iron	128-132	ferritin heavy polypeptide 1	Mus musculus	94-104
17459943-8	2007	The relative amount of iron that could be delivered via H-ferritin could make this protein a predominant player in cellular iron delivery.	Iron	23-27	ferritin heavy polypeptide 1	Mus musculus	56-66
17459943-8	2007	The relative amount of iron that could be delivered via H-ferritin could make this protein a predominant player in cellular iron delivery.	Iron	124-128	ferritin heavy polypeptide 1	Mus musculus	56-66
17584508-1	2007	Electron spin resonance (ESR) spectra of magnetic fluids involving polydispersed Zn(0.5)Fe(0.	Iron	88-90	spindlin 1	Homo sapiens	9-13
17526019-2	2007	Heme oxygenase-1 (HO-1), the rate-limiting enzyme in the oxidative degradation of heme to ferrous iron, carbon monoxide, and biliverdin, is upregulated in affected PD astroglia and may contribute to abnormal mitochondrial iron sequestration in these cells.	Iron	98-102	heme oxygenase 1	Rattus norvegicus	0-16
17526019-2	2007	Heme oxygenase-1 (HO-1), the rate-limiting enzyme in the oxidative degradation of heme to ferrous iron, carbon monoxide, and biliverdin, is upregulated in affected PD astroglia and may contribute to abnormal mitochondrial iron sequestration in these cells.	Iron	98-102	heme oxygenase 1	Rattus norvegicus	18-22
17526019-2	2007	Heme oxygenase-1 (HO-1), the rate-limiting enzyme in the oxidative degradation of heme to ferrous iron, carbon monoxide, and biliverdin, is upregulated in affected PD astroglia and may contribute to abnormal mitochondrial iron sequestration in these cells.	Iron	222-226	heme oxygenase 1	Rattus norvegicus	0-16
17526019-2	2007	Heme oxygenase-1 (HO-1), the rate-limiting enzyme in the oxidative degradation of heme to ferrous iron, carbon monoxide, and biliverdin, is upregulated in affected PD astroglia and may contribute to abnormal mitochondrial iron sequestration in these cells.	Iron	222-226	heme oxygenase 1	Rattus norvegicus	18-22
17526019-7	2007	In PD brain, overexpression of HO-1 in nigral astroglia and accompanying iron liberation may facilitate the bioactivation of dopamine to neurotoxic free radical intermediates and predispose nearby neuronal constituents to oxidative damage.	Iron	73-77	heme oxygenase 1	Rattus norvegicus	31-35
17655520-1	2007	Methemoglobin, a form of hemoglobin that does not bind oxygen, is produced when iron in red blood cells is oxidized from the ferrous state to the ferric state.	Iron	80-84	hemoglobin subunit gamma 2	Homo sapiens	0-13
17517886-0	2007	Functional characterization of AtATM1, AtATM2, and AtATM3, a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis.	Iron	148-152	myosin 1	Arabidopsis thaliana	31-37
17517886-0	2007	Functional characterization of AtATM1, AtATM2, and AtATM3, a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis.	Iron	148-152	myosin 2	Arabidopsis thaliana	39-45
17517886-2	2007	Designated AtATM1, AtAATM2, and AtATM3, these half-molecule ABC proteins are homologous to the yeast mitochondrial membrane protein ATM1 (ScATM1), which is clearly implicated in the export of mitochondrially synthesized iron/sulfur clusters.	Iron	220-224	myosin 1	Arabidopsis thaliana	11-17
17611542-10	2007	These results provide a structural framework for understanding the mechanism of disulphide reduction by an iron-sulphur enzyme and describe previously unknown interaction networks for both Fdx and Trx (refs 4-6).	Iron	107-111	ferredoxin 1	Homo sapiens	189-192
17438025-1	2007	The transferrin iron acquisition system of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requires the participation of two distinct proteins: TbpA and TbpB.	Iron	16-20	transthyretin	Homo sapiens	186-190
17438025-1	2007	The transferrin iron acquisition system of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requires the participation of two distinct proteins: TbpA and TbpB.	Iron	82-86	transthyretin	Homo sapiens	186-190
17438025-2	2007	TbpA is a TonB-dependent outer membrane transporter responsible for the transport of iron into the cell.	Iron	85-89	transthyretin	Homo sapiens	0-4
17622311-7	2007	Atherosclerotic patients (CS1 and CS2) showed increased levels of MT, MCP-1, and RANTES, reduced NK cell cytotoxicity, and altered trace element concentrations (zinc, copper, magnesium, iron).	Iron	186-190	chorionic somatomammotropin hormone 1	Homo sapiens	26-29
17533620-6	2007	Finally, the other selected genes, ISU1, involved in the biosynthesis of the iron-sulphur cluster in mitochondria, and the less well functionally defined BSC5 and YBR270c, may participate in the cell"s antioxidant and stress defence.	Iron	77-81	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	35-39
17299088-0	2007	Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.	Iron	77-81	hepcidin antimicrobial peptide	Mus musculus	124-132
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	112-120
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	122-127
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	homeostatic iron regulator	Mus musculus	169-172
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	112-120
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	hepcidin antimicrobial peptide	Mus musculus	122-127
17299088-5	2007	Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa.	Iron	90-94	homeostatic iron regulator	Mus musculus	169-172
17299088-6	2007	In young th3/+ and th3/th3 mice, low Hamp1 levels are responsible for increased iron absorption.	Iron	80-84	hepcidin antimicrobial peptide	Mus musculus	37-42
17526834-0	2007	Cloning and characterization of the genes encoding the high-affinity iron-uptake protein complex Fet3/Ftr1 in the basidiomycete Phanerochaete chrysosporium.	Iron	69-73	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	102-106
17526834-2	2007	This enzyme shows biochemical and structural similarities with the yeast Fet3p, a type I membrane glycoprotein that efficiently oxidizes Fe(II) to Fe(III) for its subsequent transport to the intracellular compartment by the iron permease Ftr1p.	Iron	224-228	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	238-243
17526834-8	2007	Northern hybridization studies showed that the mRNA levels of both genes are reduced upon supplementation of the growth medium with iron, supporting the functional coupling of Fet3 and Ftr1 proteins in vivo.	Iron	132-136	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	185-189
17264297-2	2007	Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells.	Iron	237-241	homeostatic iron regulator	Mus musculus	47-50
17264297-3	2007	Contrasting this view, Hfe deficiency causes inappropriately low expression of the hepatic iron hormone hepcidin, which causes increased duodenal iron absorption.	Iron	91-95	hepcidin antimicrobial peptide	Mus musculus	104-112
17264297-3	2007	Contrasting this view, Hfe deficiency causes inappropriately low expression of the hepatic iron hormone hepcidin, which causes increased duodenal iron absorption.	Iron	146-150	hepcidin antimicrobial peptide	Mus musculus	104-112
17264297-5	2007	Mice with efficient deletion of Hfe in crypt- and villi-enterocytes maintain physiologic iron metabolism with wild-type unsaturated iron binding capacity, hepatic iron levels, and hepcidin mRNA expression.	Iron	89-93	homeostatic iron regulator	Mus musculus	32-35
17264297-8	2007	These findings exclude a primary role for duodenal Hfe in the pathogenesis of HH and support the model according to which Hfe is required for appropriate expression of the "iron hormone" hepcidin which then controls intestinal iron absorption.	Iron	173-177	homeostatic iron regulator	Mus musculus	122-125
17264297-8	2007	These findings exclude a primary role for duodenal Hfe in the pathogenesis of HH and support the model according to which Hfe is required for appropriate expression of the "iron hormone" hepcidin which then controls intestinal iron absorption.	Iron	173-177	hepcidin antimicrobial peptide	Mus musculus	187-195
17264297-8	2007	These findings exclude a primary role for duodenal Hfe in the pathogenesis of HH and support the model according to which Hfe is required for appropriate expression of the "iron hormone" hepcidin which then controls intestinal iron absorption.	Iron	227-231	homeostatic iron regulator	Mus musculus	122-125
17264297-8	2007	These findings exclude a primary role for duodenal Hfe in the pathogenesis of HH and support the model according to which Hfe is required for appropriate expression of the "iron hormone" hepcidin which then controls intestinal iron absorption.	Iron	227-231	hepcidin antimicrobial peptide	Mus musculus	187-195
17264300-6	2007	Membrane HJV (m-HJV) is mainly composed of the cleaved protein, and its level is increased by iron in wild-type (WT) mice but not in the mutants.	Iron	94-98	hemojuvelin BMP co-receptor	Mus musculus	9-12
17264300-6	2007	Membrane HJV (m-HJV) is mainly composed of the cleaved protein, and its level is increased by iron in wild-type (WT) mice but not in the mutants.	Iron	94-98	hemojuvelin BMP co-receptor	Mus musculus	16-19
16870250-2	2007	Moderately elevated free erythrocyte protoporphyrin (FEP) levels have been described in IASA, suggesting that the activity of ferrochelatase, the enzyme that catalyzes the final step in heme biosynthesis (incorporation of ferrous iron into protoporphyrin), might be diminished in erythroid progenitor cells from IASA patients.	Iron	222-234	ferrochelatase	Homo sapiens	126-140
17524656-4	2007	We aimed to verify the interspecies compatibility of the Fe-deficiency response of NAS1 genes and understand the universal mechanisms that regulate their expression patterns in higher plants.	Iron	57-59	nicotianamine synthase	Nicotiana tabacum	83-87
17431519-2	2007	The density functional calculations give evidence of both, states with local high-spin iron centres and states with local low-spin iron centres, the relative energy of which strongly depends on the functional.	Iron	87-91	spindlin 1	Homo sapiens	82-86
17431519-2	2007	The density functional calculations give evidence of both, states with local high-spin iron centres and states with local low-spin iron centres, the relative energy of which strongly depends on the functional.	Iron	87-91	spindlin 1	Homo sapiens	126-130
17431519-2	2007	The density functional calculations give evidence of both, states with local high-spin iron centres and states with local low-spin iron centres, the relative energy of which strongly depends on the functional.	Iron	131-135	spindlin 1	Homo sapiens	82-86
17431519-2	2007	The density functional calculations give evidence of both, states with local high-spin iron centres and states with local low-spin iron centres, the relative energy of which strongly depends on the functional.	Iron	131-135	spindlin 1	Homo sapiens	126-130
17431519-3	2007	The splitting of states due to the spin coupling between the high-spin iron centres varies by more than a factor of two for different functionals.	Iron	71-75	spindlin 1	Homo sapiens	35-39
17431519-3	2007	The splitting of states due to the spin coupling between the high-spin iron centres varies by more than a factor of two for different functionals.	Iron	71-75	spindlin 1	Homo sapiens	66-70
17253959-1	2007	Recent studies suggest that NGAL (neutrophil gelatinase-associated lipocalin) is a novel iron transporter with functions distinct from that of transferrin and mediates a new iron-delivery pathway.	Iron	89-93	lipocalin 2	Homo sapiens	28-32
17253959-1	2007	Recent studies suggest that NGAL (neutrophil gelatinase-associated lipocalin) is a novel iron transporter with functions distinct from that of transferrin and mediates a new iron-delivery pathway.	Iron	89-93	lipocalin 2	Homo sapiens	34-76
17280489-4	2007	We demonstrated for the first time in vivo that the presence of catalytically active iron, deposition of myeloperoxidase, and induction of the oxidative stress in the lung-injury models were accompanied by (a) downregulation of VE-cadherin, (b) upregulation and polarization of ICAM-1 and the PLC integrins, and (c) nuclear translocation and interaction of thioredoxin, Ref-1, and NF-kappaB and complex structural changes in EC and PLC at the sites of their contacts.	Iron	85-89	intercellular adhesion molecule 1	Rattus norvegicus	278-284
17408452-8	2007	HO (inducible HO-1, constitutive HO-2 and HO-3) is the rate-limiting enzyme in haeme catabolism, which leads to the generation of biliverdin, iron, and carbon monoxide.	Iron	142-146	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	42-46
17505966-5	2007	Recent results from our group indicate that iron is required for long-term potentiation in hippocampal CA1 neurons and that iron stimulates ryanodine receptor-mediated calcium release through ROS produced via the Fenton reaction leading to stimulation of the ERK signaling pathway.	Iron	44-48	carbonic anhydrase 1	Homo sapiens	103-106
17316628-0	2007	Iron overload in Hepc1(-/-) mice is not impairing glucose homeostasis.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	17-22
17316628-3	2007	We assess glucose homeostasis status in iron-overloaded hepcidin-deficient mice.	Iron	40-44	hepcidin antimicrobial peptide	Mus musculus	56-64
17197701-3	2007	The discovery that the dinitrosyl-diglutathionyl-iron complex binds tightly to Alpha class GSTs in rat hepatocytes and that a significant part of the bound complex is also associated with the nuclear fraction (Pedersen, J.	Iron	49-53	glutathione S-transferase alpha 1	Rattus norvegicus	91-95
16986127-2	2007	Hemoglobin has iron in the reduced valance Fe(II) and methemoglobin has iron in the oxidized valance Fe (III), with a free energy capable of producing water from oxygen.	Iron	72-76	hemoglobin subunit gamma 2	Homo sapiens	54-67
17186026-3	2007	It has been reported that alanine substitution of residues in an acidic ridge of yeast frataxin (Yfh1) elicits loss of iron binding in vitro but has no effect on Fe-S cluster synthesis in vivo.	Iron	119-123	ferroxidase	Saccharomyces cerevisiae S288C	97-101
17186026-5	2007	Therefore, the acidic ridge is essential for the Yfh1 function and is likely to be involved in iron-mediated protein-protein interactions.	Iron	95-99	ferroxidase	Saccharomyces cerevisiae S288C	49-53
17258727-9	2007	In contrast, Hfe(-/-) x Cp(R435/R435X) or Cp(R435X/R435X) x Hfe(+/-) showed 30% decrease in liver iron when compared with single mutant mice.	Iron	98-102	homeostatic iron regulator	Mus musculus	13-16
17258727-9	2007	In contrast, Hfe(-/-) x Cp(R435/R435X) or Cp(R435X/R435X) x Hfe(+/-) showed 30% decrease in liver iron when compared with single mutant mice.	Iron	98-102	homeostatic iron regulator	Mus musculus	60-63
17258727-10	2007	CONCLUSIONS: This study highlights the existence of complex interactions between Cp and HFE and represents the first example of a modifier gene with a protective effect, in which heterozygosity reduces the iron load in the context of HFE deficiency.	Iron	206-210	homeostatic iron regulator	Mus musculus	88-91
16932966-1	2007	The newly discovered proteins hemojuvelin (Hjv) and transferrin receptor type 2 (TfR2) are involved in iron metabolism.	Iron	103-107	transferrin receptor 2	Rattus norvegicus	52-79
16932966-1	2007	The newly discovered proteins hemojuvelin (Hjv) and transferrin receptor type 2 (TfR2) are involved in iron metabolism.	Iron	103-107	transferrin receptor 2	Rattus norvegicus	81-85
16932966-11	2007	The localization of Hjv and TfR2 at the same membrane domain renders a functional interaction of these two proteins in iron homeostasis possible.	Iron	119-123	transferrin receptor 2	Rattus norvegicus	28-32
17460390-7	2007	Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan.	Iron	82-86	RoBo-1	Rattus norvegicus	115-119
16932993-7	2007	The synergistic effects of co-administration of clinidine (1 mg/kg) with a subthreshold dose of L-Dopa (5 mg/kg) in elevating the motor activity of MPTP mice were reduced markedly by postnatal iron administration, as well as by pretreatment with DSP4.	Iron	193-197	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	148-152
17244486-4	2007	The modification of cellular iron metabolism, which involved the increased expression of high-affinity iron transport genes (FET3 and FTR1), was detected via Northern blot analysis.	Iron	29-33	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	134-138
17244486-4	2007	The modification of cellular iron metabolism, which involved the increased expression of high-affinity iron transport genes (FET3 and FTR1), was detected via Northern blot analysis.	Iron	103-107	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	134-138
17331161-3	2007	Recently, a novel iron-regulatory hormone hepcidin was found that suppresses the absorption of iron from the small intestine and the release of iron from macrophages.	Iron	18-22	hepcidin antimicrobial peptide	Mus musculus	42-50
17331161-3	2007	Recently, a novel iron-regulatory hormone hepcidin was found that suppresses the absorption of iron from the small intestine and the release of iron from macrophages.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	42-50
17095719-6	2007	The expression of HO-1 and CD163 correlated with tissue iron content but iron itself was not associated with the symptom status.	Iron	56-60	CD163 molecule	Homo sapiens	27-32
17611950-2	2007	In situ FTIR, TPD, TPR, and chemical analysis reveal that the Cp(2)Fe molecule adsorbed on the zeolite surface loses one cyclopentadienyl group under vacuum at 423 K, which leads to the formation of a well-defined mononuclear surface Fe-C(5)H(6) complex grafted to two acidic sites and one ([triple bond]Si-O-Si[triple bond]) unit, as confirmed by the lack of Fe-Fe contributions in the EXAFS spectra.	Iron	67-69	translocated promoter region, nuclear basket protein	Homo sapiens	19-22
17617032-1	2007	BACKGROUND: Iron-induced oxidative stress may be implicated in the alteration of the lipoprotein-associated antioxidant enzymes paraoxonase 1 (PON1) and platelet-activating factor acetylhydrolase (PAF-AH), leading to atherosclerosis-related vascular complication in patients with beta-thalassemia hemoglobin E (beta-thal/Hb E).	Iron	12-16	phospholipase A2 group VII	Homo sapiens	153-195
17617032-1	2007	BACKGROUND: Iron-induced oxidative stress may be implicated in the alteration of the lipoprotein-associated antioxidant enzymes paraoxonase 1 (PON1) and platelet-activating factor acetylhydrolase (PAF-AH), leading to atherosclerosis-related vascular complication in patients with beta-thalassemia hemoglobin E (beta-thal/Hb E).	Iron	12-16	phospholipase A2 group VII	Homo sapiens	197-203
17617032-6	2007	Significant correlations of low-density lipoprotein (LDL) and HDL-PAF-AH activity with plasma iron, alpha-tocopherol and the CL/CO ratio were also demonstrated.	Iron	94-98	phospholipase A2 group VII	Homo sapiens	66-72
17116743-4	2007	Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status.	Iron	88-92	RoBo-1	Rattus norvegicus	0-28
17116743-4	2007	Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status.	Iron	88-92	RoBo-1	Rattus norvegicus	30-34
17116743-4	2007	Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status.	Iron	144-148	RoBo-1	Rattus norvegicus	0-28
17116743-4	2007	Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status.	Iron	144-148	RoBo-1	Rattus norvegicus	30-34
17116743-9	2007	The apparent function of DMT1 in olfactory manganese absorption suggests that the neurotoxicity of the metal can be modified by iron status due to the iron-responsive regulation of the transporter.	Iron	128-132	RoBo-1	Rattus norvegicus	25-29
17116743-9	2007	The apparent function of DMT1 in olfactory manganese absorption suggests that the neurotoxicity of the metal can be modified by iron status due to the iron-responsive regulation of the transporter.	Iron	151-155	RoBo-1	Rattus norvegicus	25-29
17127361-6	2007	There has been reported some differences in the Fe binding and oxidation properties between mtF and cytosolic H-ferritin suggesting that mtF functions differently as an Fe storage protein within the mitochondria and perhaps has other function(s) in Fe homeostasis as well.	Iron	169-171	ferritin heavy polypeptide 1	Mus musculus	110-120
16982849-2	2007	Hepcidin is an important iron regulatory hormone, and hemojuvelin may regulate hepcidin synthesis via the multifunctional membrane receptor neogenin.	Iron	25-29	hepcidin antimicrobial peptide	Mus musculus	0-8
16935308-4	2006	The function of hepcidin in regulating iron absorption is modeled through an inverse relationship between hepatocyte transferrin receptor 2 (TfR2) levels and the rate of iron export processes mediated by ferroportin (Fpn).	Iron	39-43	hepcidin antimicrobial peptide	Mus musculus	16-24
16935308-4	2006	The function of hepcidin in regulating iron absorption is modeled through an inverse relationship between hepatocyte transferrin receptor 2 (TfR2) levels and the rate of iron export processes mediated by ferroportin (Fpn).	Iron	39-43	transferrin receptor 2	Mus musculus	117-139
16935308-4	2006	The function of hepcidin in regulating iron absorption is modeled through an inverse relationship between hepatocyte transferrin receptor 2 (TfR2) levels and the rate of iron export processes mediated by ferroportin (Fpn).	Iron	39-43	transferrin receptor 2	Mus musculus	141-145
16935308-4	2006	The function of hepcidin in regulating iron absorption is modeled through an inverse relationship between hepatocyte transferrin receptor 2 (TfR2) levels and the rate of iron export processes mediated by ferroportin (Fpn).	Iron	170-174	hepcidin antimicrobial peptide	Mus musculus	16-24
16935308-4	2006	The function of hepcidin in regulating iron absorption is modeled through an inverse relationship between hepatocyte transferrin receptor 2 (TfR2) levels and the rate of iron export processes mediated by ferroportin (Fpn).	Iron	170-174	transferrin receptor 2	Mus musculus	141-145
16902156-1	2006	Hepcidin is the presumed negative regulator of systemic iron levels; its expression is induced in iron overload, infection, and inflammation, and by cytokines, but is suppressed in hypoxia and anemia.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	0-8
16902156-1	2006	Hepcidin is the presumed negative regulator of systemic iron levels; its expression is induced in iron overload, infection, and inflammation, and by cytokines, but is suppressed in hypoxia and anemia.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	0-8
17116712-1	2006	Patients with mutations in divalent metal transporter-1 (DMT1), an intestinal nonheme iron transporter, suffer from microcytic anemia and hepatic iron loading.	Iron	86-90	RoBo-1	Rattus norvegicus	27-55
17116712-1	2006	Patients with mutations in divalent metal transporter-1 (DMT1), an intestinal nonheme iron transporter, suffer from microcytic anemia and hepatic iron loading.	Iron	86-90	RoBo-1	Rattus norvegicus	57-61
17116716-2	2006	Our objective was to determine whether and how supplemental inulin improved utilization of iron intrinsically present in a corn and soybean meal diet by young pigs for hemoglobin repletion.	Iron	91-95	HGB	Sus scrofa	168-178
17125252-7	2006	X-ray crystal structures of CYP2A6 cocrystallized with three furan analogues bearing methanamino side chains indicated that the amine side chain coordinated to the heme iron.	Iron	169-173	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	28-34
17112287-3	2006	The interaction of 2 equiv of MX2 with L1 in n-BuOH at 110 degrees C gives the binuclear complexes, [(L1)M2X4] (M = Fe, X = Cl (1a); M = Co, X = Cl (1b); M = Ni, X = Br (1c); M = Zn, X = Cl (1d)), in which the metal centers adopt distorted tetrahedral geometries and occupy the two pyridyl-imine cavities in L1.	Iron	116-118	MX dynamin like GTPase 2	Homo sapiens	30-33
17112287-4	2006	In contrast, deprotonation of L2-H occurs upon reaction with 2 equiv of MX2 to afford the phenolate-bridged species [(L2)M2(mu-X)X2] (M = Fe, X = Cl (2a); M = Co, X = Cl (2b); M = Ni, X = Br (2c); M = Zn, X = Cl (2d)).	Iron	138-140	MX dynamin like GTPase 2	Homo sapiens	72-75
17082420-0	2006	Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1.	Iron	16-20	vacuolar iron transporter 1	Arabidopsis thaliana	84-88
17082420-3	2006	This localization is completely abolished when the vacuolar iron uptake transporter VIT1 is disrupted.	Iron	60-64	vacuolar iron transporter 1	Arabidopsis thaliana	84-88
17082420-4	2006	Vacuolar iron storage is also critical for seedling development because vit1-1 seedlings grow poorly when iron is limiting.	Iron	9-13	vacuolar iron transporter 1	Arabidopsis thaliana	72-78
17082420-4	2006	Vacuolar iron storage is also critical for seedling development because vit1-1 seedlings grow poorly when iron is limiting.	Iron	106-110	vacuolar iron transporter 1	Arabidopsis thaliana	72-78
17155772-3	2006	We found that a bulklike MgO energy gap is fully established for MgO film thicker than 3 atomic monolayers and that the electron reflectivity from the MgO/Fe interface exhibits a spin-dependent amplitude and a spin-independent phase change.	Iron	155-157	spindlin 1	Homo sapiens	179-183
17155772-3	2006	We found that a bulklike MgO energy gap is fully established for MgO film thicker than 3 atomic monolayers and that the electron reflectivity from the MgO/Fe interface exhibits a spin-dependent amplitude and a spin-independent phase change.	Iron	155-157	spindlin 1	Homo sapiens	210-214
17090681-2	2006	The complexes of primary interest in this article are the two terminal iron(IV) nitride species, [PhBP(iPr)3]Fe[triple bond]N (3a) and [PhBP(CH2Cy)3]Fe[triple bond]N (3b), and the formally diiron(I) bridged-Fe(mu-N2)Fe species, {[PhBP(iPr)3]Fe}2(mu-N2) (4).	Iron	71-75	hyaluronan binding protein 2	Homo sapiens	98-108
16978757-1	2006	Heme oxygenase-1, a stress-responsive enzyme that catabolizes hemes into carbon monoxide, biliverdin, and iron, has been shown to play a pivotal role in many physiological and pathological situations.	Iron	106-110	heme oxygenase 1	Rattus norvegicus	0-16
16959548-4	2006	Last, A-T cells exhibited increased short-term sensitivity to labile iron exposure compared to normal cells, an event corrected by recombinant ATM (rATM) expression.	Iron	69-73	ATM serine/threonine kinase	Rattus norvegicus	148-152
16959548-6	2006	We treated A-T, normal, and A-T cells expressing rATM with labile iron, iron chelators, antioxidants, and t-butyl hydroperoxide, and examined chromosomal breaks and ATM activation.	Iron	66-70	ATM serine/threonine kinase	Rattus norvegicus	49-53
17100424-0	2006	Towards understanding performance differences between approximate density functionals for spin states of iron complexes.	Iron	105-109	spindlin 1	Homo sapiens	90-94
17100424-2	2006	Nevertheless, recent studies have shown that approximate exchange-correlation energy density functionals can incorrectly predict the stability order of spin states in, for instance, iron-containing pyridine and imidazole systems.	Iron	182-186	spindlin 1	Homo sapiens	152-156
17100424-5	2006	Two oxidation states of iron, Fe(II) and Fe(III), with different spin states and both adiabatic and vertical structures are considered.	Iron	24-28	spindlin 1	Homo sapiens	65-69
17074835-9	2006	The phenotypes of the double mutant grx3grx4 characterised in this study were mainly mediated by the Aft1 function, suggesting that grx3grx4 could be a suitable cellular model for studying endogenous oxidative stress induced by deregulation of the iron homeostasis.	Iron	248-252	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	36-44
17074835-9	2006	The phenotypes of the double mutant grx3grx4 characterised in this study were mainly mediated by the Aft1 function, suggesting that grx3grx4 could be a suitable cellular model for studying endogenous oxidative stress induced by deregulation of the iron homeostasis.	Iron	248-252	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	101-105
17252785-0	2006	Synthesis of carbon nanotubes using mesoporous Fe-MCM-41 catalysts.	Iron	47-49	methylmalonyl-CoA mutase	Homo sapiens	50-53
17252785-5	2006	Fe-MCM-41 due to higher dispersion of nano-sized Fe-species was efficient as catalyst for MWNTs with more uniform size distribution.	Iron	0-2	methylmalonyl-CoA mutase	Homo sapiens	3-6
17252785-5	2006	Fe-MCM-41 due to higher dispersion of nano-sized Fe-species was efficient as catalyst for MWNTs with more uniform size distribution.	Iron	49-51	methylmalonyl-CoA mutase	Homo sapiens	3-6
17042492-0	2006	Structural basis of the ferrous iron specificity of the yeast ferroxidase, Fet3p.	Iron	32-36	ferroxidase	Saccharomyces cerevisiae S288C	62-73
17042492-1	2006	Fet3p is a multicopper oxidase (MCO) that functions together with the iron permease, Ftr1p, to support high-affinity Fe uptake in yeast.	Iron	0-2	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	85-90
17018382-9	2006	RESULTS: Hemoglobin, hematocrit and mean corpuscular volume were significantly reduced in both beta-thalassemia models, more significantly in Hbb(th/3+), which have the greater, age-dependent, iron overload.	Iron	193-197	hemoglobin beta chain complex	Mus musculus	142-145
17018382-15	2006	As we previously reported in wild type mice after parenteral iron overload, Tfr2 is reduced and Fpn RNA increased in thalassemic mice.	Iron	61-65	transferrin receptor 2	Mus musculus	76-80
16950869-4	2006	We analyzed the capability of Zip14 to mediate non-transferrin-bound iron (NTBI) uptake by overexpressing mouse Zip14 in HEK 293H cells and Sf9 insect cells.	Iron	69-73	transferrin	Mus musculus	51-62
16879716-5	2006	(59)Fe occurred in significantly lower amounts in the postvascular compartment in Belgrade b/b rats, indicating impaired iron uptake by transferrin receptor and DMT1-expressing neurons.	Iron	4-6	RoBo-1	Rattus norvegicus	161-165
16920629-9	2006	Thus, in the vast majority of eukaryotes, Jac1 and Isu function with the single, multifunctional mtHsp70 in Fe-S cluster biogenesis.	Iron	108-112	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	42-46
16574947-3	2006	At that time, although the role of USF2 was still confounding, we proposed for the first time the role of hepcidin as a negative regulator of iron absorption and iron release from macrophages.	Iron	142-146	hepcidin antimicrobial peptide	Mus musculus	106-114
16574947-3	2006	At that time, although the role of USF2 was still confounding, we proposed for the first time the role of hepcidin as a negative regulator of iron absorption and iron release from macrophages.	Iron	162-166	hepcidin antimicrobial peptide	Mus musculus	106-114
16574947-6	2006	Confirming our prior results, Hepc1(-/-) mice developed early and severe multivisceral iron overload, with sparing of the spleen macrophages, and demonstrated increased serum iron and ferritin levels as compared with their controls.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	30-35
16893174-6	2006	Here we have used site-directed mutagenesis along with UV-visible and electron paramagnetic resonance (EPR) spectroscopies to characterize and assign the heme iron axial ligands in E75.	Iron	159-163	Ecdysone-induced protein 75B	Drosophila melanogaster	181-184
16893190-1	2006	Heme-regulated eIF2alpha kinase [heme-regulated inhibitor (HRI)] plays a critical role in the regulation of protein synthesis by heme iron.	Iron	134-138	eukaryotic translation initiation factor 2A	Homo sapiens	15-24
16769722-2	2006	Yeast frataxin (Yfh1p), the homolog of the human protein implicated in Friedreich ataxia, is involved in iron homeostasis.	Iron	105-109	ferroxidase	Saccharomyces cerevisiae S288C	16-21
16880565-2	2006	MIOX utilizes an Fe(II)/Fe(III) binuclear iron centre for the dioxygen-dependent cleavage of the C1-C6 bond in MI.	Iron	42-46	myo-inositol oxygenase	Mus musculus	0-4
16565419-4	2006	We found that whereas basal hepcidin levels were manifestly dependent on the presence of Hfe and on the mouse background, all Hfe-deficient mice were still able to regulate hepcidin in situations of altered iron homeostasis.	Iron	207-211	homeostatic iron regulator	Mus musculus	126-129
16793032-6	2006	CONCLUSION: The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I.	Iron	44-48	interleukin 10	Homo sapiens	200-205
16815956-3	2006	YSL1 and YSL3 are similar to the maize (Zea mays) YS1 phytosiderophore transporter (ZmYS1) and the AtYSL2 iron (Fe)-nicotianamine transporter, and are predicted to transport metal-nicotianamine complexes into cells.	Iron	106-110	YELLOW STRIPE like 3	Arabidopsis thaliana	9-13
16815956-3	2006	YSL1 and YSL3 are similar to the maize (Zea mays) YS1 phytosiderophore transporter (ZmYS1) and the AtYSL2 iron (Fe)-nicotianamine transporter, and are predicted to transport metal-nicotianamine complexes into cells.	Iron	112-114	YELLOW STRIPE like 3	Arabidopsis thaliana	9-13
16928320-0	2006	[An iron regulator hepcidin is affected by EPO].	Iron	4-8	hepcidin antimicrobial peptide	Mus musculus	19-27
16704972-2	2006	The purified PAL catalytic core (PALcc) contains molar equivalents of calcium and zinc along with substoichiometric amounts of iron and functions as a ureidoglycolate lyase.	Iron	127-131	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	13-16
16801541-1	2006	Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4.	Iron	69-73	hepcidin antimicrobial peptide	Mus musculus	37-45
16801541-1	2006	Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4.	Iron	69-73	hemojuvelin BMP co-receptor	Mus musculus	177-180
16762569-0	2006	The CD8+ T-lymphocyte profile as a modifier of iron overload in HFE hemochromatosis: an update of clinical and immunological data from 70 C282Y homozygous subjects.	Iron	47-51	CD8a molecule	Homo sapiens	4-7
16762569-2	2006	Among other factors, the individual immunological profile of CD8+ T-lymphocytes has been described to influence the severity of iron overload, with low numbers being negatively correlated with the total amount of body iron stored.	Iron	128-132	CD8a molecule	Homo sapiens	61-64
16762569-2	2006	Among other factors, the individual immunological profile of CD8+ T-lymphocytes has been described to influence the severity of iron overload, with low numbers being negatively correlated with the total amount of body iron stored.	Iron	218-222	CD8a molecule	Homo sapiens	61-64
16762569-3	2006	With the objective of testing the modifier effect of the individual CD8+ T-lymphocyte profile on the levels of iron stores with age in HH, we reviewed the clinical and immunological data from a group of well-characterized C282Y homozygous HH subjects, regularly followed-up for a period of 20 years.	Iron	111-115	CD8a molecule	Homo sapiens	68-71
16762569-10	2006	A modifier effect of the individual CD8+ T-lymphocyte profile on the association between iron stores and age was demonstrated by multiple regression analysis, where a significant correlation between TBIS and age was found only in males with low (&lt; or = 0.41 x 10(6)/ml) CD8+ T-cell numbers (R2 = 0.43, P &lt; 0.0001).	Iron	89-93	CD8a molecule	Homo sapiens	36-39
16762569-11	2006	In conclusion, in the present population of C282Y homozygous subjects, the CD8+ T-lymphocyte profile could be considered a modifier of the iron overload with increasing age in males, with low numbers predicting a severe outcome.	Iron	139-143	CD8a molecule	Homo sapiens	75-78
16775460-0	2006	Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia.	Iron	52-56	lipocalin 2	Homo sapiens	0-42
16775460-2	2006	NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators.	Iron	130-134	lipocalin 2	Homo sapiens	0-4
16775460-6	2006	Additionally, only when complexed with siderophore and iron as a trimer, NGAL induces mesenchymal-epithelial transition (or nephron formation) in embryonic kidney in vitro and protects adult kidney from ischemia-reperfusion injury in vivo.	Iron	55-59	lipocalin 2	Homo sapiens	73-77
16775460-7	2006	While the structure of the NGAL: siderophore: iron complex has thus far only been solved for bacterially synthesized siderophores, new evidence suggests the presence of mammalian siderophore-like molecules.	Iron	46-50	lipocalin 2	Homo sapiens	27-31
16775460-8	2006	SUMMARY: NGAL is rapidly and massively induced in renal epithelial injury and NGAL: siderophore: iron complexes may comprise a physiological renoprotective mechanism.	Iron	97-101	lipocalin 2	Homo sapiens	78-82
16648636-0	2006	Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae.	Iron	49-53	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	72-76
16648636-1	2006	The transcription factors Aft1 and Aft2 from Saccharomyces cerevisiae regulate the expression of genes involved in iron homeostasis.	Iron	115-119	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	26-30
16648636-3	2006	Iron inhibition of Aft1/Aft2 was previously shown to be dependent on mitochondrial components required for cytosolic iron sulfur protein biogenesis.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	19-23
16648636-4	2006	We presently show that the nuclear monothiol glutaredoxins Grx3 and Grx4 are critical for iron inhibition of Aft1 in yeast cells.	Iron	90-94	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	59-63
16648636-4	2006	We presently show that the nuclear monothiol glutaredoxins Grx3 and Grx4 are critical for iron inhibition of Aft1 in yeast cells.	Iron	90-94	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	109-113
16648636-9	2006	The interaction between glutaredoxins and Aft1 is not modulated by the iron status of cells but is dependent on the conserved glutaredoxin domain Cys residue.	Iron	71-75	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	42-46
16648636-10	2006	Thus, Grx3 and Grx4 are novel components required for Aft1 iron regulation that most likely occurs in the nucleus.	Iron	59-63	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	6-10
16648636-10	2006	Thus, Grx3 and Grx4 are novel components required for Aft1 iron regulation that most likely occurs in the nucleus.	Iron	59-63	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	54-58
17080942-3	2006	We investigated the expression in Arabidopsis halleri of a homolog of AtMHX, an A. thaliana tonoplast transporter that exchanges protons with Mg, Zn and Fe ions.	Iron	153-155	magnesium/proton exchanger	Arabidopsis thaliana	70-75
16719927-10	2006	QTG mapped regulator-target pairs linked to ARN1 were combined to form a regulatory module, which we observed to be highly enriched in iron homeostasis related genes and contained several causally directed links that had not been identified in other automatic reconstructions of that regulatory module.	Iron	135-139	siderophore transporter	Saccharomyces cerevisiae S288C	44-48
16803146-1	2006	Iron in the major lower mantle (LM) minerals undergoes a high spin (HS) to low spin (LS) transition at relevant pressures (23-135 GPa).	Iron	0-4	spindlin 1	Homo sapiens	62-66
16803146-1	2006	Iron in the major lower mantle (LM) minerals undergoes a high spin (HS) to low spin (LS) transition at relevant pressures (23-135 GPa).	Iron	0-4	spindlin 1	Homo sapiens	79-83
16387364-8	2006	The data are consistent with a channeling model of Fe-trafficking in the Fet3p, Ftr1p complex and suggest that in this system, Fet3p serves as a redox sieve that presents Fe(III) specifically for permeation through Ftr1p.	Iron	51-53	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	80-85
16387364-8	2006	The data are consistent with a channeling model of Fe-trafficking in the Fet3p, Ftr1p complex and suggest that in this system, Fet3p serves as a redox sieve that presents Fe(III) specifically for permeation through Ftr1p.	Iron	51-53	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	215-220
16688533-2	2006	HFE, the hereditary hemochromatosis gene product, is expressed in the crypts of the duodenum, but the molecular mechanism by which it contributes to the inhibition of iron absorption is still unknown.	Iron	167-171	homeostatic iron regulator	Mus musculus	0-3
16688533-7	2006	The functional annotation of upregulated genes highlighted that mucus production and cell maintenance may account for the influence of Hfe on epithelium integrity and luminal iron uptake.	Iron	175-179	homeostatic iron regulator	Mus musculus	135-138
16637741-12	2006	CONCLUSIONS: The finding that haptoglobin 2-2 genotype is a risk factor for anaemia in children in a malaria-endemic area may reflect the reduced ability of the Hp2-2 polymer to scavenge free haemoglobin-iron following malaria-induced haemolysis.	Iron	204-208	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	161-166
16154248-3	2006	In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine.	Iron	78-82	transferrin	Mus musculus	95-106
16601688-3	2006	Herein, we describe a mechanism whereby Saccharomyces cerevisiae manganese superoxide dismutase (SOD2) preferentially binds manganese over iron based on the differential bioavailability of these ions within mitochondria.	Iron	139-143	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	97-101
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	26-30	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	271-275
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	271-275
16601688-4	2006	The bulk of mitochondrial iron is normally unavailable to SOD2, but when mitochondrial iron homeostasis is disrupted, for example, by mutations in S. cerevisiae mtm1, ssq1 and grx5, iron accumulates in a reactive form that potently competes with manganese for binding to SOD2, inactivating the enzyme.	Iron	87-91	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	271-275
16601688-5	2006	Studies in mtm1 mutants indicate that iron inactivation of SOD2 involves the Mrs3p/Mrs4p mitochondrial carriers and iron-binding frataxin (Yfh1p).	Iron	38-42	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	59-63
16601688-5	2006	Studies in mtm1 mutants indicate that iron inactivation of SOD2 involves the Mrs3p/Mrs4p mitochondrial carriers and iron-binding frataxin (Yfh1p).	Iron	38-42	ferroxidase	Saccharomyces cerevisiae S288C	139-144
16601688-5	2006	Studies in mtm1 mutants indicate that iron inactivation of SOD2 involves the Mrs3p/Mrs4p mitochondrial carriers and iron-binding frataxin (Yfh1p).	Iron	116-120	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	59-63
16600046-0	2006	Knock-out of SO1377 gene, which encodes the member of a conserved hypothetical bacterial protein family COG2268, results in alteration of iron metabolism, increased spontaneous mutation and hydrogen peroxide sensitivity in Shewanella oneidensis MR-1.	Iron	138-142	flotillin family protein	Shewanella oneidensis MR-1	13-19
16600046-10	2006	CONCLUSION: Our results showed that the knock-out of SO1377 gene had pleiotropic effects and suggested that SO1377 may play a role in iron homeostasis and oxidative damage protection in S. oneidensis MR-1.	Iron	134-138	flotillin family protein	Shewanella oneidensis MR-1	53-59
16600046-10	2006	CONCLUSION: Our results showed that the knock-out of SO1377 gene had pleiotropic effects and suggested that SO1377 may play a role in iron homeostasis and oxidative damage protection in S. oneidensis MR-1.	Iron	134-138	flotillin family protein	Shewanella oneidensis MR-1	108-114
16332970-2	2006	Hepcidin is an acute-phase protein with specific iron regulatory properties, which, along with the anemia seen with increased hepcidin expression, have led many to consider it the major mediator of ACD.	Iron	49-53	hepcidin antimicrobial peptide	Mus musculus	0-8
16332970-6	2006	These studies suggest that hepcidin may contribute to anemia in ACD not only through effects on iron metabolism, but also through inhibition of erythroid progenitor proliferation and survival.	Iron	96-100	hepcidin antimicrobial peptide	Mus musculus	27-35
16339398-0	2006	Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice.	Iron	83-87	hepcidin antimicrobial peptide	Mus musculus	8-16
16339398-1	2006	We report the generation of a tetracycline-regulated (Tet ON) transgenic mouse model for acute and chronic expression of the iron regulatory peptide hepcidin in the liver.	Iron	125-129	hepcidin antimicrobial peptide	Mus musculus	149-157
16339398-2	2006	We demonstrate that short-term and long-term tetracycline-dependent activation of hepcidin in adult mice leads to hypoferremia and iron-limited erythropoiesis, respectively.	Iron	131-135	hepcidin antimicrobial peptide	Mus musculus	82-90
16339398-3	2006	This clearly establishes the key role of hepcidin in regulating the extracellular iron concentration.	Iron	82-86	hepcidin antimicrobial peptide	Mus musculus	41-49
16339398-4	2006	We previously demonstrated that, when expressed early in fetal development, constitutive transgenic hepcidin expression prevented iron accumulation in an Hfe-/- mouse model of hemochromatosis.	Iron	130-134	hepcidin antimicrobial peptide	Mus musculus	100-108
16339398-6	2006	We demonstrate that induction of chronic hepcidin expression in 2-month-old Hfe-/- mice alters their pattern of cellular iron accumulation, leading to increased iron in tissue macrophages and duodenal cells but less iron in hepatocytes.	Iron	121-125	hepcidin antimicrobial peptide	Mus musculus	41-49
16339398-6	2006	We demonstrate that induction of chronic hepcidin expression in 2-month-old Hfe-/- mice alters their pattern of cellular iron accumulation, leading to increased iron in tissue macrophages and duodenal cells but less iron in hepatocytes.	Iron	121-125	homeostatic iron regulator	Mus musculus	76-79
16339398-6	2006	We demonstrate that induction of chronic hepcidin expression in 2-month-old Hfe-/- mice alters their pattern of cellular iron accumulation, leading to increased iron in tissue macrophages and duodenal cells but less iron in hepatocytes.	Iron	161-165	hepcidin antimicrobial peptide	Mus musculus	41-49
16339398-6	2006	We demonstrate that induction of chronic hepcidin expression in 2-month-old Hfe-/- mice alters their pattern of cellular iron accumulation, leading to increased iron in tissue macrophages and duodenal cells but less iron in hepatocytes.	Iron	161-165	hepcidin antimicrobial peptide	Mus musculus	41-49
16339398-7	2006	These hepcidin-induced changes in the pattern of cellular iron accumulation are associated with decreased expression of the iron exporter ferroportin in macrophages but no detectable alteration of ferroportin expression in the hepatocytes.	Iron	58-62	hepcidin antimicrobial peptide	Mus musculus	6-14
16339398-7	2006	These hepcidin-induced changes in the pattern of cellular iron accumulation are associated with decreased expression of the iron exporter ferroportin in macrophages but no detectable alteration of ferroportin expression in the hepatocytes.	Iron	124-128	hepcidin antimicrobial peptide	Mus musculus	6-14
16337798-0	2006	Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer"s disease.	Iron	41-45	renin binding protein	Mus musculus	0-3
16455656-0	2006	CpSufE activates the cysteine desulfurase CpNifS for chloroplastic Fe-S cluster formation.	Iron	67-71	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	42-48
16455656-11	2006	The iron-sulfur cluster reconstitution activity of the CpNifS-CpSufE complex toward apoferredoxin was 20-fold higher than that of CpNifS alone.	Iron	4-8	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	55-61
16455656-11	2006	The iron-sulfur cluster reconstitution activity of the CpNifS-CpSufE complex toward apoferredoxin was 20-fold higher than that of CpNifS alone.	Iron	4-8	chloroplastic NIFS-like cysteine desulfurase	Arabidopsis thaliana	130-136
16431909-1	2006	The specialized yeast mitochondrial chaperone system, composed of the Hsp70 Ssq1p, its co-chaperone J-protein Jac1p, and the nucleotide release factor Mge1p, perform a critical function in the biogenesis of iron-sulfur (Fe/S) proteins.	Iron	220-222	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	110-115
16431909-3	2006	In the absence of chaperones, the kinetics of Fe/S cluster formation on Isu1p were compatible with a chemical reconstitution pathway with Nfs1p functioning as a sulfide donor.	Iron	46-48	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	72-77
16509978-11	2006	CONCLUSION: The present study provides evidence supporting an inextricable link between extended HLA haplotypes, CD8+ T-lymphocyte numbers and severity of iron overload in hereditary hemochromatosis(HH).	Iron	155-159	CD8a molecule	Homo sapiens	113-116
16520242-6	2006	The course of iron release during the various incubations was analogous to that of the 170-kDa band blots, and significant correlations were found at 0 and 48 h. Methemoglobin formation roughly paralleled iron release.	Iron	14-18	hemoglobin subunit gamma 2	Homo sapiens	162-175
16520242-6	2006	The course of iron release during the various incubations was analogous to that of the 170-kDa band blots, and significant correlations were found at 0 and 48 h. Methemoglobin formation roughly paralleled iron release.	Iron	205-209	hemoglobin subunit gamma 2	Homo sapiens	162-175
16208485-6	2006	Parallel studies were performed for the primary iron absorption protein, divalent metal transporter 1 (DMT1).	Iron	48-52	RoBo-1	Rattus norvegicus	103-107
16208485-9	2006	DMT1 was localised primarily on the microvillus membrane, but did partially co-localise with HFE raising the possibility that the two proteins may interact to regulate iron absorption.	Iron	168-172	RoBo-1	Rattus norvegicus	0-4
16386335-10	2006	The synaptosomes isolated from gerbil pre-injected with FAEE and subsequently treated with AAPH or Fe(2+)/H(2)O(2) showed induction of heme oxygenase (HO-1) and heat shock protein 70 (HSP-70) but reduced inducible nitric oxide synthase (iNOS) levels.	Iron	99-101	heat shock protein family A (Hsp70) member 4	Homo sapiens	161-182
16386335-10	2006	The synaptosomes isolated from gerbil pre-injected with FAEE and subsequently treated with AAPH or Fe(2+)/H(2)O(2) showed induction of heme oxygenase (HO-1) and heat shock protein 70 (HSP-70) but reduced inducible nitric oxide synthase (iNOS) levels.	Iron	99-101	heat shock protein family A (Hsp70) member 4	Homo sapiens	184-190
16469498-4	2006	We evaluate the recently recognized interaction between ferrochelatase and frataxin as a way to regulate iron delivery to ferrochelatase, and thus iron and heme metabolism.	Iron	105-109	ferrochelatase	Homo sapiens	56-70
16469498-4	2006	We evaluate the recently recognized interaction between ferrochelatase and frataxin as a way to regulate iron delivery to ferrochelatase, and thus iron and heme metabolism.	Iron	105-109	ferrochelatase	Homo sapiens	122-136
16469498-4	2006	We evaluate the recently recognized interaction between ferrochelatase and frataxin as a way to regulate iron delivery to ferrochelatase, and thus iron and heme metabolism.	Iron	147-151	ferrochelatase	Homo sapiens	56-70
16469498-4	2006	We evaluate the recently recognized interaction between ferrochelatase and frataxin as a way to regulate iron delivery to ferrochelatase, and thus iron and heme metabolism.	Iron	147-151	ferrochelatase	Homo sapiens	122-136
16478282-2	2006	Our objective was to test the effectiveness of soy root nodule (SRN) and purified soy hemoglobin (LHb) in improving iron bioavailability using an in vitro Caco-2 cell model, with ferritin response as the bioavailability index.	Iron	116-120	luteinizing hormone subunit beta	Homo sapiens	98-101
16424901-0	2006	Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.	Iron	0-4	aconitase 1	Mus musculus	31-56
16424901-1	2006	The generally accepted role of iron-regulatory protein 1 (IRP1) in orchestrating the fate of iron-regulated mRNAs depends on the interconversion of its cytosolic aconitase and RNA-binding forms through assembly/disassembly of its Fe-S cluster, without altering protein abundance.	Iron	31-35	aconitase 1	Mus musculus	58-62
16424901-2	2006	Here, we show that IRP1 protein abundance can be iron-regulated.	Iron	49-53	aconitase 1	Mus musculus	19-23
16424901-3	2006	Modulation of IRP1 abundance by iron did not require assembly of the Fe-S cluster, since a mutant with all cluster-ligating cysteines mutated to serine underwent iron-induced protein degradation.	Iron	32-36	aconitase 1	Mus musculus	14-18
16424901-3	2006	Modulation of IRP1 abundance by iron did not require assembly of the Fe-S cluster, since a mutant with all cluster-ligating cysteines mutated to serine underwent iron-induced protein degradation.	Iron	162-166	aconitase 1	Mus musculus	14-18
16424901-4	2006	Phosphorylation of IRP1 at S138 favored the RNA-binding form and promoted iron-dependent degradation.	Iron	74-78	aconitase 1	Mus musculus	19-23
16424901-9	2006	Our results reveal a mechanism for regulating IRP1 action relevant to the control of iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly.	Iron	85-89	aconitase 1	Mus musculus	46-50
16424901-9	2006	Our results reveal a mechanism for regulating IRP1 action relevant to the control of iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly.	Iron	190-194	aconitase 1	Mus musculus	46-50
16116031-8	2006	To demonstrate transketolase activity ultrastructurally in liver parenchymal cells, the cupper iron method was used.	Iron	95-99	transketolase	Rattus norvegicus	15-28
16337890-6	2006	Furthermore, the combination of free fatty acid and iron is highly mutagenic, inducing almost as many selectable mutations in the gene for hypoxanthine/guanine phosphoribosyl transferase as does benzo[a]pyrenediolepoxide, a class I carcinogen generated from benzo[a]pyrene present in cigarette smoke.	Iron	52-56	hypoxanthine-guanine phosphoribosyltransferase	Nicotiana tabacum	139-186
16319128-7	2006	Other significantly up-regulated gene categories in FH mutants were, for example, iron ion homeostasis and oxidoreduction.	Iron	82-86	fumarate hydratase	Homo sapiens	52-54
16679553-3	2006	Iron-induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase- 3 activation, NF-kappaB induction, and decreased Bcl-2 expression, without any significant change in Bax expression.	Iron	0-4	caspase 3	Mus musculus	159-169
16679553-3	2006	Iron-induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase- 3 activation, NF-kappaB induction, and decreased Bcl-2 expression, without any significant change in Bax expression.	Iron	0-4	BCL2-associated X protein	Mus musculus	269-272
17017521-2	2006	Frataxin participates in the synthesis of iron-sulfur clusters (ISCs), cofactors of several enzymes, including mitochondrial and cytosolic aconitase, complexes I, II and III of the respiratory chain, and ferrochelatase.	Iron	42-46	ferrochelatase	Homo sapiens	129-218
16497104-1	2006	Hepcidin, a key regulator of iron metabolism, decreases intestinal absorption of iron and its release from macrophages.	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	0-8
16249327-1	2006	Three nuclear genes, SDH2-1, SDH2-2 and SDH2-3, encode the essential iron-sulfur subunit of mitochondrial complex II in Arabidopsis thaliana.	Iron	69-73	succinate dehydrogenase 2-1	Arabidopsis thaliana	21-27
16249327-1	2006	Three nuclear genes, SDH2-1, SDH2-2 and SDH2-3, encode the essential iron-sulfur subunit of mitochondrial complex II in Arabidopsis thaliana.	Iron	69-73	succinate dehydrogenase 2-2	Arabidopsis thaliana	29-35
16288996-7	2005	Moreover, an iron-chelator, desferrioxamine, which sequesters iron preventing the ferrochelatase reaction, enhanced the photo-damage as well as the accumulation of protoporphyrin in ALA-treated L929 cells.	Iron	13-17	ferrochelatase	Mus musculus	82-96
16270029-0	2005	Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron.	Iron	25-29	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	33-41
16270029-0	2005	Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron.	Iron	25-29	natural resistance associated macrophage protein 4	Arabidopsis thaliana	46-54
16270029-0	2005	Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron.	Iron	96-100	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	33-41
16270029-0	2005	Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron.	Iron	96-100	natural resistance associated macrophage protein 4	Arabidopsis thaliana	46-54
16270029-6	2005	Indeed, the germination of nramp3 nramp4 double mutants is arrested under low Fe nutrition and fully rescued by high Fe supply.	Iron	78-80	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	27-33
16270029-6	2005	Indeed, the germination of nramp3 nramp4 double mutants is arrested under low Fe nutrition and fully rescued by high Fe supply.	Iron	78-80	natural resistance associated macrophage protein 4	Arabidopsis thaliana	34-40
16270029-6	2005	Indeed, the germination of nramp3 nramp4 double mutants is arrested under low Fe nutrition and fully rescued by high Fe supply.	Iron	117-119	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	27-33
16270029-6	2005	Indeed, the germination of nramp3 nramp4 double mutants is arrested under low Fe nutrition and fully rescued by high Fe supply.	Iron	117-119	natural resistance associated macrophage protein 4	Arabidopsis thaliana	34-40
16270029-9	2005	Our data indicate that mobilization of vacuolar Fe stores by AtNRAMP3 and AtNRAMP4 is crucial to support Arabidopsis early development until efficient systems for Fe acquisition from the soil take over.	Iron	48-50	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	61-69
16270029-9	2005	Our data indicate that mobilization of vacuolar Fe stores by AtNRAMP3 and AtNRAMP4 is crucial to support Arabidopsis early development until efficient systems for Fe acquisition from the soil take over.	Iron	48-50	natural resistance associated macrophage protein 4	Arabidopsis thaliana	74-82
16270029-9	2005	Our data indicate that mobilization of vacuolar Fe stores by AtNRAMP3 and AtNRAMP4 is crucial to support Arabidopsis early development until efficient systems for Fe acquisition from the soil take over.	Iron	163-165	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	61-69
16270029-9	2005	Our data indicate that mobilization of vacuolar Fe stores by AtNRAMP3 and AtNRAMP4 is crucial to support Arabidopsis early development until efficient systems for Fe acquisition from the soil take over.	Iron	163-165	natural resistance associated macrophage protein 4	Arabidopsis thaliana	74-82
16316349-1	2005	BACKGROUND: The heme oxygenase system (HO-1 and HO-2) catalyzes the conversion of heme to free iron, carbon monoxide (CO), a vasodepressor, and biliverdin, which is further converted to bilirubin, an antioxidant.	Iron	95-99	heme oxygenase 1	Rattus norvegicus	39-43
15951234-2	2005	Ternary Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and UO2(II) complexes with piroxicam (Pir) drug (H2L1) and dl-alanine (Ala) (HL2) and also the binary UO2(II) complex with Pir were studied.	Iron	8-10	asialoglycoprotein receptor 2	Homo sapiens	125-128
16285738-1	2005	Insulysin (IDE) and neprilysin (NEP) were found to be inactivated by oxidation with hydrogen peroxide, an iron-ascorbate oxidation system, and by treatment with 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH).	Iron	106-110	insulin degrading enzyme	Homo sapiens	0-9
16285738-1	2005	Insulysin (IDE) and neprilysin (NEP) were found to be inactivated by oxidation with hydrogen peroxide, an iron-ascorbate oxidation system, and by treatment with 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH).	Iron	106-110	insulin degrading enzyme	Homo sapiens	11-14
16100038-6	2005	Chelation of iron suppressed aortic induction of ferritin and also the oxidative stress markers, heme oxygenase-1 and 4-hydroxynonenal-modified protein adducts.	Iron	13-17	heme oxygenase 1	Rattus norvegicus	97-119
16293774-7	2005	It is hypothesised that cytochrome b(5) promotes the cleavage by aligning the iron-oxygen complex attack onto the C(20) rather than the C(17) atom of the steroid substrate molecule.	Iron	78-82	mitochondrially encoded cytochrome b	Homo sapiens	24-36
16244908-8	2005	A GST (glutathione S-transferase) fusion protein of AtPAP23 (GST:AtPAP23) was expressed in bacterial cells, and was found to contain significant amounts of Fe and Mn (whereas the control GST protein contained none).	Iron	156-158	purple acid phosphatase 23	Arabidopsis thaliana	52-59
16244908-8	2005	A GST (glutathione S-transferase) fusion protein of AtPAP23 (GST:AtPAP23) was expressed in bacterial cells, and was found to contain significant amounts of Fe and Mn (whereas the control GST protein contained none).	Iron	156-158	purple acid phosphatase 23	Arabidopsis thaliana	65-72
16181413-2	2005	Accordingly, iron chelators, antioxidants and MAO-B inhibitors have shown efficacy in a variety of cellular and animal models of CNS injury.	Iron	13-17	monoamine oxidase B	Rattus norvegicus	46-51
16164960-7	2005	We conclude that iron-containing PM particles can activate NF-kappaB via a pathway involving Src and the EGF receptor.	Iron	17-21	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	93-96
16164960-7	2005	We conclude that iron-containing PM particles can activate NF-kappaB via a pathway involving Src and the EGF receptor.	Iron	17-21	epidermal growth factor receptor	Rattus norvegicus	105-117
15933050-10	2005	The rapid and sustained action of a single dose of hepcidin makes it an appealing agent for the prevention of iron accumulation in hereditary hemochromatosis.	Iron	110-114	hepcidin antimicrobial peptide	Mus musculus	51-59
16201664-5	2005	A relation describing this condition has been derived: PH2SS = [Rcorr/ ks]2 For the granular irons considered in this study, PH2SS values vary from less than one to eight bars, in contrast to the calculated thermodynamic equilibrium PH2 values for anaerobic corrosion, which range from 138 to 631 bar depending on the assumed product of corrosion.	Iron	93-98	polyhomeotic homolog 2	Homo sapiens	55-58
15993492-7	2005	Exogenous iron was shown to reverse the ability of IFN-gamma/LPS pulsed bovine macrophages to restrict M. bovis replication.	Iron	10-14	interferon gamma	Bos taurus	51-60
16106293-7	2005	Together the results reveal that for the "natural" C-2 stereochemistry of 2S-naringenin, C-3 hydroxylation predominates (&gt;9 : 1) over desaturation, probably due to the inaccessibility of the C-2 hydrogen to the iron centre.	Iron	214-218	complement C3	Homo sapiens	89-92
16048487-1	2005	Reticulocyte hemoglobin content (CHr) is considered an index of iron status, helpful in the differential diagnosis of microcytoses.	Iron	64-68	chromate resistance; sulfate transport	Homo sapiens	33-36
15744772-0	2005	Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis.	Iron	44-48	homeostatic iron regulator	Mus musculus	88-91
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	homeostatic iron regulator	Mus musculus	3-6
15744772-3	2005	In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	77-85
15744772-4	2005	In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels.	Iron	55-59	homeostatic iron regulator	Mus musculus	3-6
15744772-4	2005	In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	16-24
15744772-5	2005	Accordingly, HFE -/- mice presented with high duodenal Dcytb and DMT-1 levels, and increased IRP and TfR expression, suggesting iron deficiency in the enterocyte and increased iron absorption.	Iron	128-132	homeostatic iron regulator	Mus musculus	13-16
15744772-7	2005	Our data suggest that the feed back regulation of duodenal iron absorption by hepcidin is impaired in HFE -/- mice, a model for genetic hemochromatosis.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	78-86
15744772-7	2005	Our data suggest that the feed back regulation of duodenal iron absorption by hepcidin is impaired in HFE -/- mice, a model for genetic hemochromatosis.	Iron	59-63	homeostatic iron regulator	Mus musculus	102-105
15744772-8	2005	This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption.	Iron	43-47	transferrin receptor 2	Mus musculus	88-93
15744772-8	2005	This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption.	Iron	43-47	hepcidin antimicrobial peptide	Mus musculus	139-147
15744772-8	2005	This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption.	Iron	216-220	transferrin receptor 2	Mus musculus	88-93
16132699-4	2005	Fe levels were increased in sod 2 Delta following H(2)O(2) In addition, the sod 2 Delta mutant was more sensitive to H(2)O(2) treatment than the wild-type.	Iron	0-2	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	28-33
16132699-4	2005	Fe levels were increased in sod 2 Delta following H(2)O(2) In addition, the sod 2 Delta mutant was more sensitive to H(2)O(2) treatment than the wild-type.	Iron	0-2	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	76-81
16132699-6	2005	This increased iron demand in the sod 2 Delta mutant may be a reflection of the cells" efforts to reconstitute proteins that are inactivated in conditions of excess superoxide.	Iron	15-19	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	34-39
16240177-8	2005	The MT1 knockdown plant lines were all hypersensitive to Cd and accumulated several fold lower levels of As, Cd, and Zn than wildtype, while Cu and Fe levels were unaffected.	Iron	148-150	metallothionein 1A	Arabidopsis thaliana	4-7
16051145-6	2005	The oxidation state of the heme iron also determines whether E75 can interact with its heterodimer partner DHR3, suggesting an additional role as a redox sensor.	Iron	32-36	Ecdysone-induced protein 75B	Drosophila melanogaster	61-64
15713792-0	2005	Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice.	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	56-64
15713792-1	2005	Evidence is accumulating that hepcidin, a liver regulatory peptide, could be the common pathogenetic denominator of all forms of iron overload syndromes including HFE-related hemochromatosis, the most prevalent genetic disorder characterized by inappropriate iron absorption.	Iron	129-133	hepcidin antimicrobial peptide	Mus musculus	30-38
15718038-1	2005	Mutations in the Hfe gene can be associated with the iron overload disorder known as hemochromatosis.	Iron	53-57	homeostatic iron regulator	Mus musculus	17-20
15718038-6	2005	The labile iron pool was consistently decreased when Hfe expression increased.	Iron	11-15	homeostatic iron regulator	Mus musculus	53-56
15845367-2	2005	TRACP has a binuclear iron center with a redox-active iron that has been shown to catalyze the formation of reactive oxygen species (ROS) by Fenton"s reaction.	Iron	22-26	acid phosphatase 5, tartrate resistant	Mus musculus	0-5
15845367-2	2005	TRACP has a binuclear iron center with a redox-active iron that has been shown to catalyze the formation of reactive oxygen species (ROS) by Fenton"s reaction.	Iron	54-58	acid phosphatase 5, tartrate resistant	Mus musculus	0-5
15637178-4	2005	Genes encoding the apical iron transport-related proteins [divalent metal transporter 1 (DMT1) and duodenal cytochrome b] were strongly induced at all ages studied, whereas increases in mRNA encoding the basolateral proteins iron-regulated gene 1 and hephaestin were observed only by real-time PCR.	Iron	26-30	RoBo-1	Rattus norvegicus	59-87
15637178-4	2005	Genes encoding the apical iron transport-related proteins [divalent metal transporter 1 (DMT1) and duodenal cytochrome b] were strongly induced at all ages studied, whereas increases in mRNA encoding the basolateral proteins iron-regulated gene 1 and hephaestin were observed only by real-time PCR.	Iron	26-30	RoBo-1	Rattus norvegicus	89-93
15637178-11	2005	We speculate that dietary iron deprivation leads to increased intestinal copper absorption via DMT1 on the brush-border membrane and the Menkes copper ATPase on the basolateral membrane.	Iron	26-30	RoBo-1	Rattus norvegicus	95-99
15793843-0	2005	Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	31-39
15793843-1	2005	Hepcidin, a recently discovered iron regulatory peptide, is believed to inhibit the release of iron from absorptive enterocytes and macrophages.	Iron	32-36	hepcidin antimicrobial peptide	Mus musculus	0-8
15793843-2	2005	Liver hepcidin synthesis is induced in vivo by iron stores and inflammation.	Iron	47-51	hepcidin antimicrobial peptide	Mus musculus	6-14
15793843-5	2005	For this, we depleted Kupffer cells by injection of liposome-encapsulated clodronate and then studied iron- and inflammation-induced hepcidin gene expression.	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	133-141
15793843-7	2005	Our results show that iron is able to induce hepcidin gene expression independently of Kupffer cells in the liver and circulating IL-6.	Iron	22-26	hepcidin antimicrobial peptide	Mus musculus	45-53
15793843-9	2005	In conclusion, these results show that two independent regulatory pathways control hepcidin gene expression and suggest that hepatocytes play a key role in the regulation of hepcidin gene expression by sensing iron and inflammatory signals.	Iron	210-214	hepcidin antimicrobial peptide	Mus musculus	174-182
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	98-102	homeostatic iron regulator	Mus musculus	19-22
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	98-102	haptoglobin	Mus musculus	27-38
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	98-102	haptoglobin	Mus musculus	147-158
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	173-177	homeostatic iron regulator	Mus musculus	19-22
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	173-177	haptoglobin	Mus musculus	27-38
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	173-177	haptoglobin	Mus musculus	147-158
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	173-177	homeostatic iron regulator	Mus musculus	19-22
15613548-7	2005	Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH.	Iron	173-177	haptoglobin	Mus musculus	27-38
15793279-0	2005	Plasma protein haptoglobin modulates renal iron loading.	Iron	43-47	haptoglobin	Mus musculus	15-26
15793279-2	2005	The strength of hemoglobin binding and the existence of a specific receptor for the haptoglobin-hemoglobin complex in the monocyte/macrophage system clearly suggest that haptoglobin may have a crucial role in heme-iron recovery.	Iron	214-218	haptoglobin	Mus musculus	84-95
15793279-2	2005	The strength of hemoglobin binding and the existence of a specific receptor for the haptoglobin-hemoglobin complex in the monocyte/macrophage system clearly suggest that haptoglobin may have a crucial role in heme-iron recovery.	Iron	214-218	haptoglobin	Mus musculus	170-181
15793279-3	2005	We used haptoglobin-null mice to evaluate the impact of haptoglobin gene inactivation on iron metabolism.	Iron	89-93	haptoglobin	Mus musculus	56-67
15793279-7	2005	These data demonstrate that haptoglobin crucially prevents glomerular filtration of hemoglobin and, consequently, renal iron loading during aging and following acute plasma heme-protein overload.	Iron	120-124	haptoglobin	Mus musculus	28-39
15819897-3	2005	Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb.	Iron	233-237	neuroglobin	Homo sapiens	118-121
15819897-3	2005	Moreover, flash photolysis experiments at high temperatures reveal that Ngb remains functional at 90 degrees C. Human Ngb may have a disulfide bond in the CD loop region; reduction of the disulfide bond increases the affinity of the iron atom for the distal (E7) histidine, and leads to a 3 degrees C increase in the T(m) for ferrous Ngb.	Iron	233-237	neuroglobin	Homo sapiens	118-121
15825077-11	2005	In CRC cells, CDX2 induction suppressed intracellular iron levels, consistent with the view that HEPH regulates iron export.	Iron	54-58	caudal type homeobox 2	Homo sapiens	14-18
15825077-11	2005	In CRC cells, CDX2 induction suppressed intracellular iron levels, consistent with the view that HEPH regulates iron export.	Iron	112-116	caudal type homeobox 2	Homo sapiens	14-18
15825077-11	2005	In CRC cells, CDX2 induction suppressed intracellular iron levels, consistent with the view that HEPH regulates iron export.	Iron	112-116	hephaestin	Homo sapiens	97-101
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	70-74	caudal type homeobox 2	Homo sapiens	0-4
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	70-74	caudal type homeobox 2	Homo sapiens	176-180
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	70-74	hephaestin	Homo sapiens	185-189
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	132-136	caudal type homeobox 2	Homo sapiens	0-4
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	132-136	caudal type homeobox 2	Homo sapiens	176-180
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	132-136	hephaestin	Homo sapiens	185-189
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	132-136	caudal type homeobox 2	Homo sapiens	0-4
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	132-136	caudal type homeobox 2	Homo sapiens	176-180
15825077-12	2005	CDX2 expression was modulated in response to changes in intracellular iron levels, implying a regulatory pathway in which increased iron levels lead to increased expression of CDX2 and HEPH and enhanced iron export.	Iron	132-136	hephaestin	Homo sapiens	185-189
15825077-13	2005	CONCLUSIONS: CDX2 has a key role in regulating HEPH expression and iron levels in intestinal cells.	Iron	67-71	caudal type homeobox 2	Homo sapiens	13-17
15853921-4	2005	Furthermore, IL-10 mRNA was higher in parasite blood smear-positive children than in blood smear-negative children irrespective of their iron status.	Iron	137-141	interleukin 10	Homo sapiens	13-18
15649888-0	2005	Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis.	Iron	119-123	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	44-48
15649888-1	2005	Two transcriptional activators, Aft1 and Aft2, regulate iron homeostasis in Saccharomyces cerevisiae.	Iron	56-60	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	32-36
15649888-3	2005	Iron inhibition of Aft1/Aft2 is abrogated in cells defective for Fe-S cluster biogenesis within the mitochondrial matrix (Chen, O. S., Crisp, R. J., Valachovic, M., Bard, M., Winge, D. R., and Kaplan, J.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	19-23
15649888-3	2005	Iron inhibition of Aft1/Aft2 is abrogated in cells defective for Fe-S cluster biogenesis within the mitochondrial matrix (Chen, O. S., Crisp, R. J., Valachovic, M., Bard, M., Winge, D. R., and Kaplan, J.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	19-23
15649888-7	2005	To determine whether iron sensing by Aft1/Aft2 requires the function of the mitochondrial Fe-S export and cytosolic Fe-S protein assembly systems, we evaluated the expression of the iron regulon in cells depleted of glutathione and in cells depleted of Atm1, Nar1, Cfd1, and Nbp35.	Iron	21-25	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	37-41
15649888-8	2005	The iron regulon is induced in cells depleted of Atm1 with Aft1 largely responsible for the induced gene expression.	Iron	4-8	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	59-63
15649888-12	2005	Thus, iron sensing by Aft1/Aft2 is not linked to the maturation of cytosolic/nuclear Fe-S proteins, but the mitochondrial inner membrane transporter Atm1 is important to transport the inhibitory signal.	Iron	6-10	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	22-26
15649888-13	2005	Although Aft1 and Aft2 sense a signal emanating from the Fe-S cluster biogenesis pathway, there is no indication that the proteins are inhibited by direct binding of an Fe-S cluster.	Iron	57-61	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	9-13
15528318-0	2005	The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells.	Iron	66-70	hereditary hemochromatosis protein	Cricetulus griseus	40-43
15528318-2	2005	The most common form of HH is caused by a single amino acid substitution in the HH protein, HFE, but the mechanism by which HFE regulates iron homeostasis is not known.	Iron	138-142	hereditary hemochromatosis protein	Cricetulus griseus	124-127
15528318-6	2005	These data indicate that HFE can regulate intracellular iron storage independently of its interaction with TfR1.	Iron	56-60	hereditary hemochromatosis protein	Cricetulus griseus	25-28
15528318-7	2005	Earlier studies found that in HeLa cells, HFE expression lowers Tf-mediated iron uptake; here we show that HFE lowers non-Tf-bound iron in TRVb cells and add to a growing body of evidence that HFE may play different roles in different cell types.	Iron	131-135	hereditary hemochromatosis protein	Cricetulus griseus	107-110
15788228-1	2005	Flavonoids were examined for synergistic effects with ascorbate on enhancement of DNA degradation induced by a bleomycin(BLM)-Fe complex.	Iron	126-128	BLM RecQ like helicase	Homo sapiens	121-124
15788228-9	2005	Therefore, it is suggested that the synergistic DNA degradation caused by flavonoids and ascorbate in the BLM-Fe redox cycle arose from the difference in the reductive processes in which flavonoids and ascorbate mainly act.	Iron	110-112	BLM RecQ like helicase	Homo sapiens	106-109
15799959-7	2005	Further work established that compound 1 was a potent intracellular iron chelator that inhibited both IL-12/IL-18- and IL-4-mediated T cell proliferation.	Iron	68-72	interleukin 18	Homo sapiens	108-113
15799959-9	2005	Thus, the IL-12/IL-18-mediated proliferation and IFN-gamma secretion are very sensitive to intracellular iron concentration.	Iron	105-109	interleukin 18	Homo sapiens	16-21
15629469-1	2005	Iron regulatory protein 1 (IRP1) is a bifunctional [4Fe-4S] protein that controls iron homeostasis.	Iron	82-86	aconitase 1	Mus musculus	0-25
15629469-1	2005	Iron regulatory protein 1 (IRP1) is a bifunctional [4Fe-4S] protein that controls iron homeostasis.	Iron	82-86	aconitase 1	Mus musculus	27-31
15629469-2	2005	Switching off its function from an aconitase to an apo-IRP1 interacting with iron-responsive element-containing mRNAs depends on the reduced availability of iron in labile iron pool (LIP).	Iron	77-81	aconitase 1	Mus musculus	55-59
15629469-2	2005	Switching off its function from an aconitase to an apo-IRP1 interacting with iron-responsive element-containing mRNAs depends on the reduced availability of iron in labile iron pool (LIP).	Iron	157-161	aconitase 1	Mus musculus	55-59
15629469-2	2005	Switching off its function from an aconitase to an apo-IRP1 interacting with iron-responsive element-containing mRNAs depends on the reduced availability of iron in labile iron pool (LIP).	Iron	157-161	aconitase 1	Mus musculus	55-59
15699234-2	2005	Whether intestinal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), are present in the mammary gland and are involved in iron transfer into milk are unknown.	Iron	19-23	RoBo-1	Rattus norvegicus	38-66
15699234-2	2005	Whether intestinal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), are present in the mammary gland and are involved in iron transfer into milk are unknown.	Iron	19-23	RoBo-1	Rattus norvegicus	68-72
15699234-10	2005	DMT1, FPN1, and transferrin receptor values were unchanged; however, a smaller-size DMT1 protein was observed in the low-iron rats.	Iron	121-125	RoBo-1	Rattus norvegicus	84-88
15699234-12	2005	CONCLUSIONS: The results show that DMT1 and FPN1 concentrations are higher during early lactation and are possibly involved in iron transfer into milk.	Iron	127-131	RoBo-1	Rattus norvegicus	35-39
15494544-10	2005	This effect was observed for at least 48 h post-Fe injection, a time at which plasma iron levels were increased by levels insufficient to fully saturate transferrin.	Iron	48-50	transferrin	Mus musculus	153-164
15865416-6	2005	Functional complementation experiments in yeast strains with impaired metal transport systems, revealed that C. reinhardtii DMT1 has a broad specificity, acting in the transport of several divalent metals (manganese, iron, cadmium, copper), but excluding zinc.	Iron	217-221	uncharacterized protein	Chlamydomonas reinhardtii	124-128
15664936-1	2005	Neisseria meningitidis, a causative agent of bacterial meningitis and septicemia, obtains transferrin-bound iron by expressing two outer membrane-located transferrin-binding proteins, TbpA and TbpB.	Iron	108-112	transthyretin	Homo sapiens	184-188
15664936-11	2005	However, iron loss from the diferric human transferrin-TbpA-TbpB complex was not greater than that from human transferrin alone, suggesting that additional meningococcal transport components are involved in the process of iron removal.	Iron	9-13	transthyretin	Homo sapiens	55-59
15664936-11	2005	However, iron loss from the diferric human transferrin-TbpA-TbpB complex was not greater than that from human transferrin alone, suggesting that additional meningococcal transport components are involved in the process of iron removal.	Iron	222-226	transthyretin	Homo sapiens	55-59
15659676-0	2005	Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in Escherichia coli.	Iron	47-51	catabolite gene activator protein	Escherichia coli	76-79
15659676-3	2005	Many iron transport genes and several carbon metabolic genes are subject to dual control, being repressed by the loss of Crp and activated by the loss of Fur.	Iron	5-9	catabolite gene activator protein	Escherichia coli	121-124
15665091-0	2005	Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	126-134
15665091-6	2005	Treatment of cells with the peptide hormone hepcidin, a systemic regulator of iron metabolism, dramatically decreased FPN1 protein levels and significantly reduced the efflux of 59Fe after erythrophagocytosis.	Iron	78-82	hepcidin antimicrobial peptide	Mus musculus	44-52
15670845-0	2005	The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake.	Iron	41-45	lipocalin 2	Homo sapiens	59-101
15670845-2	2005	NGAL binds bacterial siderophores preventing bacteria from retrieving iron from this source.	Iron	70-74	lipocalin 2	Homo sapiens	0-4
15670845-3	2005	Also, NGAL may be important in delivering iron to cells during formation of the tubular epithelial cells of the primordial kidney.	Iron	42-46	lipocalin 2	Homo sapiens	6-10
15537639-0	2005	Fluctuations of intracellular iron modulate elastin production.	Iron	30-34	elastin	Homo sapiens	44-51
15537639-3	2005	In the present report we demonstrate that treatment of cultured human skin fibroblasts with low concentration of iron 2-20 microm (ferric ammonium citrate) induced a significant increase in the synthesis of tropoelastin and deposition of insoluble elastin.	Iron	113-117	elastin	Homo sapiens	212-219
15537639-4	2005	Northern blot and real-time reverse transcription-PCR analysis revealed that treatment with 20 microm iron led to an increase of approximately 3-fold in elastin mRNA levels.	Iron	102-106	elastin	Homo sapiens	153-160
15537639-5	2005	Because treatment with an intracellular iron chelator, desferrioxamine, caused a significant decrease in elastin mRNA level and consequent inhibition of elastin deposition, we conclude that iron facilitates elastin gene expression.	Iron	40-44	elastin	Homo sapiens	105-112
15537639-5	2005	Because treatment with an intracellular iron chelator, desferrioxamine, caused a significant decrease in elastin mRNA level and consequent inhibition of elastin deposition, we conclude that iron facilitates elastin gene expression.	Iron	40-44	elastin	Homo sapiens	153-160
15537639-5	2005	Because treatment with an intracellular iron chelator, desferrioxamine, caused a significant decrease in elastin mRNA level and consequent inhibition of elastin deposition, we conclude that iron facilitates elastin gene expression.	Iron	40-44	elastin	Homo sapiens	153-160
15537639-5	2005	Because treatment with an intracellular iron chelator, desferrioxamine, caused a significant decrease in elastin mRNA level and consequent inhibition of elastin deposition, we conclude that iron facilitates elastin gene expression.	Iron	190-194	elastin	Homo sapiens	105-112
15537639-5	2005	Because treatment with an intracellular iron chelator, desferrioxamine, caused a significant decrease in elastin mRNA level and consequent inhibition of elastin deposition, we conclude that iron facilitates elastin gene expression.	Iron	190-194	elastin	Homo sapiens	153-160
15537639-5	2005	Because treatment with an intracellular iron chelator, desferrioxamine, caused a significant decrease in elastin mRNA level and consequent inhibition of elastin deposition, we conclude that iron facilitates elastin gene expression.	Iron	190-194	elastin	Homo sapiens	153-160
15537639-6	2005	Our experimental evidence also demonstrates the existence of an opposite effect, in which higher, but not cytotoxic concentrations of iron (100-400 microm) induced the production of intracellular reactive oxygen species that coincided with a significant decrease in elastin message stability and the disappearance of iron-dependent stimulatory effect on elastogenesis.	Iron	134-138	elastin	Homo sapiens	266-273
15537639-8	2005	Thus, presented data, for the first time, demonstrate the existence of two opposite iron-dependent mechanisms that may affect the steady state of elastin message.	Iron	84-88	elastin	Homo sapiens	146-153
15866286-0	2005	Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis.	Iron	8-12	homeostatic iron regulator	Mus musculus	52-55
15866286-0	2005	Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis.	Iron	40-44	homeostatic iron regulator	Mus musculus	52-55
15345587-1	2005	Transferrin receptor 2 (TfR2) is a membrane glycoprotein that mediates cellular iron uptake from holotransferrin.	Iron	80-84	transferrin receptor 2	Mus musculus	0-22
15345587-1	2005	Transferrin receptor 2 (TfR2) is a membrane glycoprotein that mediates cellular iron uptake from holotransferrin.	Iron	80-84	transferrin receptor 2	Mus musculus	24-28
15345587-4	2005	In this study, we further analyzed the phenotype as well as iron-related gene expression in these mice by comparing the TfR2-mutant and wild-type siblings.	Iron	60-64	transferrin receptor 2	Mus musculus	120-124
15345587-5	2005	Northern blot analyses showed that the levels of expression of hepcidin mRNA in the liver were generally lower, whereas those of duodenal DMT1, the main transporter for uptake of dietary iron, were higher in the TfR2-mutant mice as compared to the wild-type siblings.	Iron	187-191	transferrin receptor 2	Mus musculus	212-216
15345587-6	2005	Expression of hepcidin mRNA in the TfR2 mutant mice remained low even after intraperitoneal iron loading.	Iron	92-96	hepcidin antimicrobial peptide	Mus musculus	14-22
15345587-8	2005	These results suggest that up-regulation of hepcidin expression by inflammatory stimuli is independent of TfR2 and that TfR2 is upstream of hepcidin in the regulatory pathway of body iron homeostasis.	Iron	183-187	transferrin receptor 2	Mus musculus	120-124
15345587-8	2005	These results suggest that up-regulation of hepcidin expression by inflammatory stimuli is independent of TfR2 and that TfR2 is upstream of hepcidin in the regulatory pathway of body iron homeostasis.	Iron	183-187	hepcidin antimicrobial peptide	Mus musculus	140-148
16305465-3	2005	We review our current understanding of the intestinal absorption of iron in the light of recently identified membrane proteins, namely the ferrric reductase, Dcytb, the two iron(II) transport proteins, DMT1 and ferroportin/Ireg1, and hephaestin, the membrane-bound homologue of the ferroxidase ceruloplasmin.	Iron	68-72	cytochrome b reductase 1	Homo sapiens	158-163
15986999-11	2005	OBJECTIVE: In the literature, there are no relevant publications concerning the AOX formation of wastewater by wet oxidation-iron catalysed or by application of UV.	Iron	125-129	acyl-CoA oxidase 1	Homo sapiens	80-83
15578731-4	2005	Iron-deficient heterozygous and wild-type mice both had significantly greater plasma Tf levels (37.5 and 42.5 microM) than control mice had (heterozygous and wild-type controls were 20 and 32.5 microM) and far more than homozygous mice (&lt;0.2 microM) had, thus providing five distinct levels of plasma Tf concentrations.	Iron	0-4	transferrin	Mus musculus	304-306
15578731-11	2005	In wild-type and heterozygous mice, (59)Fe uptake was inversely related to brain Tf and was independent of regional brain iron concentrations and plasma Tf levels or saturation.	Iron	40-42	transferrin	Mus musculus	81-83
15750726-4	2005	FRR3 was found to be homologous to ISU1 and ISU2 of S. cerevisiae, which form mitochondrial iron-sulfur complexes; FRR4 was found to be homologous to YFH1, the yeast frataxin homologue, which also participates in iron-sulfur cluster biogenesis.	Iron	92-96	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	35-39
15750726-4	2005	FRR3 was found to be homologous to ISU1 and ISU2 of S. cerevisiae, which form mitochondrial iron-sulfur complexes; FRR4 was found to be homologous to YFH1, the yeast frataxin homologue, which also participates in iron-sulfur cluster biogenesis.	Iron	92-96	putative iron-binding protein ISU2	Saccharomyces cerevisiae S288C	44-48
15732013-11	2005	Dogs with low CHr had significantly lower HCT, MCV, serum Fe, and % sat values than did control dogs.	Iron	58-60	chromate resistance; sulfate transport	Homo sapiens	14-17
15732013-12	2005	In addition, dogs with low CHr or low rMCV values had a higher frequency of microcytosis, anemia, low serum Fe concentration, and low % sat than did control dogs.	Iron	108-110	chromate resistance; sulfate transport	Homo sapiens	27-30
15732013-14	2005	CHr and rMCV hold promise as noninvasive, cost-effective measures of iron status in the dog.	Iron	69-73	chromate resistance; sulfate transport	Homo sapiens	0-3
15531878-0	2004	Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.	Iron	87-91	lipocalin 2	Homo sapiens	0-11
15531878-7	2004	Upon encountering invading bacteria the Toll-like receptors on immune cells stimulate the transcription, translation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial growth by sequestrating the iron-laden siderophore.	Iron	218-222	lipocalin 2	Homo sapiens	156-167
15315977-2	2004	Expression of HAMP is regulated by iron status or infection, whereas regulation of HJV is yet unknown.	Iron	35-39	hepcidin antimicrobial peptide	Mus musculus	14-18
15315977-3	2004	Using quantitative real-time polymerase chain reaction, we compared expression of Hamp and Rgmc (the murine ortholog of HJV) in livers of mice treated with iron, erythropoietin, or lipopolysaccharide (LPS), as well as during fetal and postnatal development.	Iron	156-160	hepcidin antimicrobial peptide	Mus musculus	82-86
15315977-4	2004	Iron overload increased Hamp expression without effect on Rgmc mRNA.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	24-28
15584724-2	2004	A key step of the highly convergent route to this structurally rather unusual macrodiolide derivative consists of a newly developed, highly syn selective formation of allenol 6 by an iron-catalyzed ring opening reaction of the enantioenriched propargyl epoxide 5 (derived from a Sharpless epoxidation) with a Grignard reagent.	Iron	183-187	synemin	Homo sapiens	140-143
15282194-3	2004	The reporters were also sufficiently sensitive to distinguish apo- from holotransferrin in the medium, to detect the effect of modifiers of the transferrin pathway such as HFE, and to detect the donation or chelation of iron by siderophores bound to the lipocalin neutrophil gelatinase-associated lipocalin (Ngal).	Iron	220-224	lipocalin 2	Homo sapiens	308-312
15659798-10	2004	The accumulation of tissue iron and ferritin also frequently occurs in CD163-positive and vessel-rich regions in the advanced atheroma.	Iron	27-31	CD163 molecule	Homo sapiens	71-76
15663190-4	2004	During aerobic and iron repleted growth conditions, the expression of the MnSOD and FeSOD enzymes were higher, and an atypical SOD was also expressed.	Iron	19-23	superoxide dismutase 2	Rattus norvegicus	74-79
15576352-1	2004	The Escherichia coli AlkB protein repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions in DNA and RNA by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively.	Iron	167-179	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	21-25
15539473-9	2004	We propose a new model for iron uptake in Arabidopsis where FRO2 and IRT1 are differentially regulated by FIT1.	Iron	27-31	iron-regulated transporter 1	Arabidopsis thaliana	69-73
15563621-0	2004	Nuclear SDH2-1 and SDH2-2 genes, encoding the iron-sulfur subunit of mitochondrial complex II in Arabidopsis, have distinct cell-specific expression patterns and promoter activities.	Iron	46-50	succinate dehydrogenase 2-1	Arabidopsis thaliana	8-14
15563621-0	2004	Nuclear SDH2-1 and SDH2-2 genes, encoding the iron-sulfur subunit of mitochondrial complex II in Arabidopsis, have distinct cell-specific expression patterns and promoter activities.	Iron	46-50	succinate dehydrogenase 2-2	Arabidopsis thaliana	19-25
15486216-8	2004	RESULTS: SPIO labeling caused a strong R2* effect that increased linearly with iron dose; R2* increase for cells labeled for 48 hours with 50 microg of iron per milliliter was 50 sec(-1) per million cells per milliliter.	Iron	152-156	secretory blood group 1, pseudogene	Homo sapiens	179-185
15601111-1	2004	Quantitative analysis of spatially resolved valence electron energy-loss spectra shows strong physical property contrasts for Sigma5 and near Sigma13 grain boundaries in Fe-doped SrTiO3, resulting in London dispersion interaction energies of 14 to 50 mJ/m(2) between the adjacent grains.	Iron	170-172	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	126-132
15601029-3	2004	This confirms the calculations, suggesting that a similar evolution is valid for hcp iron, the main constituent of the Earth"s inner core, up to the highest investigated pressure.	Iron	85-89	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	81-84
15358806-10	2004	Iron-responsive element (IRE)-regulated divalent metal transporter 1 (DMT1) increased in maternal and neonatal liver.	Iron	0-4	RoBo-1	Rattus norvegicus	70-74
15308612-3	2004	Mice with targeted deletion of the hemochromatosis gene (Hfe(-/-)) on the 129/Sv genetic background exhibited a 72% increase in iron content in the islets of Langerhans compared with wild-type controls.	Iron	128-132	homeostatic iron regulator	Mus musculus	57-60
15804830-4	2004	Together with the observation that the distal ligand of the heme iron is the endogenous E7-histidine in both the ferric and ferrous form of neuroglobin and cytoglobin, the flexibility of the heme environment in neuroglobin will play a crucial role in the globins" ability to bind and stabilize exogenous ligands.	Iron	65-69	neuroglobin	Homo sapiens	140-151
15804830-4	2004	Together with the observation that the distal ligand of the heme iron is the endogenous E7-histidine in both the ferric and ferrous form of neuroglobin and cytoglobin, the flexibility of the heme environment in neuroglobin will play a crucial role in the globins" ability to bind and stabilize exogenous ligands.	Iron	65-69	neuroglobin	Homo sapiens	211-222
15804833-4	2004	As with some plant and bacterial globins, neuroglobin and cytoglobin hemes are hexacoordinate in the absence of external ligands, in that the heme iron atom coordinates both a proximal and a distal His residue.	Iron	147-151	neuroglobin	Homo sapiens	42-53
15469901-1	2004	Melanotransferrin (MTf) or melanoma tumor antigen p97 is a membrane-bound transferrin (Tf) homologue that binds iron (Fe).	Iron	112-116	melanotransferrin	Rattus norvegicus	0-17
15469901-1	2004	Melanotransferrin (MTf) or melanoma tumor antigen p97 is a membrane-bound transferrin (Tf) homologue that binds iron (Fe).	Iron	118-120	melanotransferrin	Rattus norvegicus	0-17
15312748-1	2004	Ferrochelatase (FECH), the last enzyme of the heme biosynthetic pathway, catalyzes the insertion of iron into protoporphyrin to form heme.	Iron	100-104	ferrochelatase	Homo sapiens	0-14
15312748-1	2004	Ferrochelatase (FECH), the last enzyme of the heme biosynthetic pathway, catalyzes the insertion of iron into protoporphyrin to form heme.	Iron	100-104	ferrochelatase	Homo sapiens	16-20
15315826-6	2004	The positive regulation of iron responsive element (IRE)-DMT1 gene was found, with different extent, in both experimental groups.	Iron	27-31	RoBo-1	Rattus norvegicus	57-61
15272411-8	2004	CONCLUSION: Iron promotes the translation of HCV by stimulating the expression of eIF3, which may be one reason for the negative association between liver iron overload and HCV infection.	Iron	155-159	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	82-86
15247539-4	2004	RECENT FINDINGS: Recent developments in genetics, including the finding of mutations in the pantothenate kinase gene and ferritin light chain gene, have demonstrated a direct relationship between the presence of a mutation in the iron-regulatory pathways and iron deposition in the brain resulting in neurodegeneration.	Iron	230-234	ferritin light chain	Homo sapiens	121-141
15247539-4	2004	RECENT FINDINGS: Recent developments in genetics, including the finding of mutations in the pantothenate kinase gene and ferritin light chain gene, have demonstrated a direct relationship between the presence of a mutation in the iron-regulatory pathways and iron deposition in the brain resulting in neurodegeneration.	Iron	259-263	ferritin light chain	Homo sapiens	121-141
15211518-2	2004	Adrenodoxin reductase homologue (Arh1) and yeast adrenodoxin homologue (Yah1) are essential Saccharomyces cerevisiae mitochondrial proteins involved in heme A biosynthesis and in iron-sulfur cluster (FeSC) assembly.	Iron	179-183	ferredoxin reductase	Bos taurus	0-21
15382617-0	2004	[Hepcidin, the negative regulator of iron absorbtion].	Iron	37-41	hepcidin antimicrobial peptide	Mus musculus	1-9
15382617-5	2004	Hepcidin is an acute phase peptide, its production is increased in inflammation and in iron overload.	Iron	87-91	hepcidin antimicrobial peptide	Mus musculus	0-8
15382617-6	2004	According to evidence obtained in mouse models hepcidin decreases the iron absorbtion in the small intestine and inhibits iron release from macrophage and iron transport across placenta.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	47-55
15382617-6	2004	According to evidence obtained in mouse models hepcidin decreases the iron absorbtion in the small intestine and inhibits iron release from macrophage and iron transport across placenta.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	47-55
15382617-6	2004	According to evidence obtained in mouse models hepcidin decreases the iron absorbtion in the small intestine and inhibits iron release from macrophage and iron transport across placenta.	Iron	122-126	hepcidin antimicrobial peptide	Mus musculus	47-55
15382617-7	2004	Hereby the hepcidin decreases the plasma iron level.	Iron	41-45	hepcidin antimicrobial peptide	Mus musculus	11-19
15382617-9	2004	The discovery of hepcidin and its role in iron metabolism could lead to new diagnostic possibilities on the field of hemochromatosis, other iron-regulatory diseases and anaemia of inflammation.	Iron	42-46	hepcidin antimicrobial peptide	Mus musculus	17-25
15382617-9	2004	The discovery of hepcidin and its role in iron metabolism could lead to new diagnostic possibilities on the field of hemochromatosis, other iron-regulatory diseases and anaemia of inflammation.	Iron	140-144	hepcidin antimicrobial peptide	Mus musculus	17-25
14988066-0	2004	Copper overload affects copper and iron metabolism in Hep-G2 cells.	Iron	35-39	DNL-type zinc finger	Homo sapiens	54-57
14988066-9	2004	Our data indicate that, as a result of Cu overload, Hep-G2 cells reduced their Fe content and their DMT1 protein levels.	Iron	79-81	DNL-type zinc finger	Homo sapiens	52-55
14988066-10	2004	These findings strongly suggest a relationship between Cu and Fe homeostasis in Hep-G2 cells in which Cu accumulation downregulates DMT1 activity.	Iron	62-64	DNL-type zinc finger	Homo sapiens	80-83
15192265-2	2004	Ingested bovine iron-unsaturated LF, apo-bLF, suppresses VEGF-A-mediated angiogenesis in a previously described rat mesentery angiogenesis assay, possibly explaining, at least in part, its established anticancer effect in rats and mice.	Iron	16-20	vascular endothelial growth factor A	Bos taurus	57-63
15532727-1	2004	All organisms utilize ferrochelatase (EC 4.99.1.1) to catalyze the insertion of ferrous iron into protoposphyrin IX in the terminal step of the heme biosynthetic pathway.	Iron	80-92	ferrochelatase	Homo sapiens	22-36
15532727-1	2004	All organisms utilize ferrochelatase (EC 4.99.1.1) to catalyze the insertion of ferrous iron into protoposphyrin IX in the terminal step of the heme biosynthetic pathway.	Iron	80-92	ferrochelatase	Homo sapiens	38-49
15123683-0	2004	Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis.	Iron	18-22	ferrochelatase	Homo sapiens	35-49
15123683-1	2004	Human ferrochelatase, a mitochondrial membrane-associated protein, catalyzes the terminal step of heme biosynthesis by insertion of ferrous iron into protoporphyrin IX.	Iron	132-144	ferrochelatase	Homo sapiens	6-65
15123683-2	2004	The recently solved x-ray structure of human ferrochelatase identifies a potential binding site for an iron donor protein on the matrix side of the homodimer.	Iron	103-107	ferrochelatase	Homo sapiens	45-59
15123683-3	2004	Herein we demonstrate Hs holofrataxin to be a high affinity iron binding partner for Hs ferrochelatase that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis.	Iron	60-64	ferrochelatase	Homo sapiens	88-102
15123683-3	2004	Herein we demonstrate Hs holofrataxin to be a high affinity iron binding partner for Hs ferrochelatase that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis.	Iron	60-64	ferrochelatase	Homo sapiens	146-160
15123683-3	2004	Herein we demonstrate Hs holofrataxin to be a high affinity iron binding partner for Hs ferrochelatase that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis.	Iron	138-142	ferrochelatase	Homo sapiens	88-102
15123683-3	2004	Herein we demonstrate Hs holofrataxin to be a high affinity iron binding partner for Hs ferrochelatase that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis.	Iron	138-142	ferrochelatase	Homo sapiens	146-160
15123683-5	2004	In essence, the distinct binding affinities of holofrataxin to the target proteins, ferrochelatase (heme synthesis) and ISU (iron-sulfur cluster synthesis), allows discrimination between the two major iron-dependent pathways and facilitates targeted heme biosynthesis following down-regulation of frataxin.	Iron	201-205	ferrochelatase	Homo sapiens	84-98
15182949-0	2004	Activation of HIF-1alpha mRNA by hypoxia and iron chelator in isolated rat carotid body.	Iron	45-49	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	14-24
15182949-1	2004	The hypoxia inducible factor-1alpha (HIF-1alpha) protein level is increased by hypoxia and iron chelator (ciclopirox olamine) in isolated rat carotid body (CB) and glomus cells.	Iron	91-95	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	4-35
15182949-1	2004	The hypoxia inducible factor-1alpha (HIF-1alpha) protein level is increased by hypoxia and iron chelator (ciclopirox olamine) in isolated rat carotid body (CB) and glomus cells.	Iron	91-95	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	37-47
15087449-1	2004	To elucidate the mechanisms of cuproprotein biosynthesis in the secretory pathway, a polyclonal antiserum was generated against hephaestin, a multicopper oxidase essential for enteric iron absorption.	Iron	184-188	hephaestin	Homo sapiens	128-138
15087449-7	2004	Taken together, these studies demonstrate the presence of a quality control system for posttranslational protein modification occurring beyond the endoplasmic reticulum that, in the case of hephaestin, directly links the rate of enteric iron uptake to nutritional copper status.	Iron	237-241	hephaestin	Homo sapiens	190-200
14992688-1	2004	Ftr1p is the permease component of the Fet3p-Ftr1p high affinity iron-uptake complex, in the plasma membrane of Saccharomyces cerevisiae, that transports the Fe3+ produced by the Fet3p ferroxidase into the cell.	Iron	65-69	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	0-5
14992688-1	2004	Ftr1p is the permease component of the Fet3p-Ftr1p high affinity iron-uptake complex, in the plasma membrane of Saccharomyces cerevisiae, that transports the Fe3+ produced by the Fet3p ferroxidase into the cell.	Iron	65-69	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	45-50
14992688-1	2004	Ftr1p is the permease component of the Fet3p-Ftr1p high affinity iron-uptake complex, in the plasma membrane of Saccharomyces cerevisiae, that transports the Fe3+ produced by the Fet3p ferroxidase into the cell.	Iron	65-69	ferroxidase	Saccharomyces cerevisiae S288C	185-196
14992688-5	2004	Alanine substitutions at any one of these combined six arginine or glutamic acid residues inactivated Ftr1p in iron uptake, indicating that both motifs were essential to iron permeation.	Iron	111-115	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	102-107
14992688-5	2004	Alanine substitutions at any one of these combined six arginine or glutamic acid residues inactivated Ftr1p in iron uptake, indicating that both motifs were essential to iron permeation.	Iron	170-174	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	102-107
14992688-8	2004	The double substitution to AASA in the latter, inactivated Ftr1p in iron uptake while the Ftr1p(E89A) mutant had only 20% of wild-type activity.	Iron	68-72	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	59-64
14992688-9	2004	The two REXLE and the EDLWE and DASE motifs are strongly conserved among fungal Ftr1p homologues, suggesting that these motifs are essential to iron permeation.	Iron	144-148	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	80-85
14992688-12	2004	Ile369 was the only residue identified in this domain that made such a major contribution to iron uptake by the Fet3p-Ftr1p complex.	Iron	93-97	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	118-123
14981080-1	2004	Ferrochelatase catalyzes the terminal step of the heme biosynthetic pathway by inserting ferrous iron into protoporphyrin IX.	Iron	89-101	ferrochelatase	Mus musculus	0-14
14993228-3	2004	The list includes several key genes in copper and iron homeostasis, such as CCC2, RCS1, FET3, LYS7, and CTR1.	Iron	50-54	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	82-86
15190970-12	2004	Iron supplementation after cecal ligation and puncture increased apoptosis by both active caspase 3 and hematoxylin and eosin staining in both the intestinal epithelium and spleen at 24 hrs (p &lt; .05).	Iron	0-4	caspase 3	Mus musculus	90-99
15081108-4	2004	With regard to iron metabolism, we showed that HEPH, SLC11A2, SLC11A3, and TF are significantly up-regulated, while ATP7B and SLC39A1 (and SFT) are down-regulated and ACO1, dCYTb, FECH, and FTH1 show constant expression.	Iron	15-19	hephaestin	Homo sapiens	47-51
15131800-5	2004	To circumvent these difficulties, we used 2 strains of mice made deficient for the Hfe gene that strongly differ in their propensity to develop hepatic iron loading.	Iron	152-156	homeostatic iron regulator	Mus musculus	83-86
15131800-9	2004	CONCLUSIONS: Our data provide a clear demonstration of the polygenic pattern of hepatic iron loading inheritance in Hfe-deficient mice.	Iron	88-92	homeostatic iron regulator	Mus musculus	116-119
15110862-1	2004	Social life is prone to invasion by microorganisms, and binding of ferric ions by transferrin is an efficient strategy to restrict their access to iron.	Iron	147-151	transferrin	Apis mellifera	82-93
15111112-1	2004	Transferrin binding protein A (TbpA) is a TonB-dependent outer membrane protein expressed by pathogenic bacteria for iron acquisition from human transferrin.	Iron	117-121	transthyretin	Homo sapiens	0-29
15111112-1	2004	Transferrin binding protein A (TbpA) is a TonB-dependent outer membrane protein expressed by pathogenic bacteria for iron acquisition from human transferrin.	Iron	117-121	transthyretin	Homo sapiens	31-35
14656877-5	2004	Our studies revealed that introduction of Rag1 deficiency in Hfe knock-out mice leads to heightened iron overload, mainly in the liver, whereas the heart and pancreas are relatively spared compared with beta2mRag1(-/-) mice.	Iron	100-104	recombination activating 1	Mus musculus	42-46
14656877-5	2004	Our studies revealed that introduction of Rag1 deficiency in Hfe knock-out mice leads to heightened iron overload, mainly in the liver, whereas the heart and pancreas are relatively spared compared with beta2mRag1(-/-) mice.	Iron	100-104	homeostatic iron regulator	Mus musculus	61-64
14701678-8	2004	Iron binding assays with rat adrenal cortex extracts further identified a 90-kDa melanotransferrin immunoreactive protein binding iron, suggesting that the identified protein, which we name "adrenotransferrin," may have iron-binding activity.	Iron	220-224	melanotransferrin	Rattus norvegicus	81-98
14640978-0	2004	Role of transient receptor potential canonical 6 (TRPC6) in non-transferrin-bound iron uptake in neuronal phenotype PC12 cells.	Iron	82-86	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	8-48
14640978-0	2004	Role of transient receptor potential canonical 6 (TRPC6) in non-transferrin-bound iron uptake in neuronal phenotype PC12 cells.	Iron	82-86	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	50-55
14640978-11	2004	However, when iron (Fe2+ and Fe3+) was added before adding phenylephrine or DAG, the fluorescence intensity decreased more rapidly in transfected cells compared with untransfected cells, thereby indicating a greater stimulation of the NTBI uptake in cells expressing TRPC6.	Iron	14-18	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	267-272
15046341-3	2004	The work reported here was initiated to investigate the transformation of RDX by ferrous iron (Fe(II)) associated with a mineral surface.	Iron	81-93	radixin	Homo sapiens	74-77
15046341-11	2004	The degradation of RDX by Fe(II)-magnetite suspensions indicates a possible remedial option that could be employed in natural and engineered environments where iron oxides are abundant and ferrous iron is present.	Iron	144-148	radixin	Homo sapiens	19-22
15268476-0	2004	Spin and charge distribution in iron porphyrin models: a coupled cluster and density-functional study.	Iron	32-36	spindlin 1	Homo sapiens	0-4
14759565-2	2004	Hsp32, also known as heme oxygenase 1, catalyzes the degradation of heme to produce carbon monoxide and bilirubin, which play a variety of cytoprotective functions at physiological concentrations, and iron, which is rapidly sequestered by the iron-binding protein ferritin.	Iron	201-205	heme oxygenase 1	Rattus norvegicus	0-5
14759565-2	2004	Hsp32, also known as heme oxygenase 1, catalyzes the degradation of heme to produce carbon monoxide and bilirubin, which play a variety of cytoprotective functions at physiological concentrations, and iron, which is rapidly sequestered by the iron-binding protein ferritin.	Iron	201-205	heme oxygenase 1	Rattus norvegicus	21-37
14759565-2	2004	Hsp32, also known as heme oxygenase 1, catalyzes the degradation of heme to produce carbon monoxide and bilirubin, which play a variety of cytoprotective functions at physiological concentrations, and iron, which is rapidly sequestered by the iron-binding protein ferritin.	Iron	243-247	heme oxygenase 1	Rattus norvegicus	0-5
14759565-2	2004	Hsp32, also known as heme oxygenase 1, catalyzes the degradation of heme to produce carbon monoxide and bilirubin, which play a variety of cytoprotective functions at physiological concentrations, and iron, which is rapidly sequestered by the iron-binding protein ferritin.	Iron	243-247	heme oxygenase 1	Rattus norvegicus	21-37
14981211-7	2004	Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin).	Iron	23-27	homeostatic iron regulator	Mus musculus	113-116
14981211-7	2004	Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin).	Iron	23-27	cytochrome b5 reductase 3	Mus musculus	119-131
14726953-0	2004	Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.	Iron	21-25	iron responsive element binding protein 2	Mus musculus	65-90
14726953-1	2004	The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level.	Iron	8-12	aconitase 1	Mus musculus	33-37
14726953-1	2004	The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level.	Iron	8-12	iron responsive element binding protein 2	Mus musculus	42-46
14726953-1	2004	The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level.	Iron	8-12	transferrin	Mus musculus	80-91
14726953-1	2004	The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level.	Iron	153-157	aconitase 1	Mus musculus	33-37
14726953-1	2004	The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level.	Iron	153-157	iron responsive element binding protein 2	Mus musculus	42-46
14726953-1	2004	The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level.	Iron	153-157	transferrin	Mus musculus	80-91
14726953-3	2004	IRP1-/- mice misregulate iron metabolism only in the kidney and brown fat, two tissues in which the endogenous expression level of IRP1 greatly exceeds that of IRP2, whereas IRP2-/- mice misregulate the expression of target proteins in all tissues.	Iron	25-29	aconitase 1	Mus musculus	0-4
14726953-7	2004	Thus, IRP2 dominates post-transcriptional regulation of iron metabolism in mammals.	Iron	56-60	iron responsive element binding protein 2	Mus musculus	6-10
14739928-2	2004	FRE2 encoding a plasma membrane ferric reductase is induced by the iron-responsive, DNA-binding, transcriptional activator Aft1.	Iron	67-71	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	123-127
14739928-8	2004	Therefore, transcriptional activation in response to iron availability involves multiple protein interactions between the Aft1 iron-responsive DNA-binding factor and global regulators such as Nhp6 and Ssn6.	Iron	53-57	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	122-126
14739928-8	2004	Therefore, transcriptional activation in response to iron availability involves multiple protein interactions between the Aft1 iron-responsive DNA-binding factor and global regulators such as Nhp6 and Ssn6.	Iron	127-131	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	122-126
15014911-6	2004	We also show that both iron and zinc are transported by DMT1 when expressed in Xenopus laevis oocytes.	Iron	23-27	solute carrier family 11 member 2 L homeolog	Xenopus laevis	56-60
15471345-1	2004	The reaction of small ligands within the distal pocket of haem proteins such as myoglobin, to form ligated, low-spin iron complexes is an archetypal spin-forbidden process in bioinorganic chemistry, because the initial, "deoxy" iron complex has a high-spin ground state.	Iron	117-121	spindlin 1	Homo sapiens	112-116
15471345-1	2004	The reaction of small ligands within the distal pocket of haem proteins such as myoglobin, to form ligated, low-spin iron complexes is an archetypal spin-forbidden process in bioinorganic chemistry, because the initial, "deoxy" iron complex has a high-spin ground state.	Iron	117-121	spindlin 1	Homo sapiens	149-153
15471345-1	2004	The reaction of small ligands within the distal pocket of haem proteins such as myoglobin, to form ligated, low-spin iron complexes is an archetypal spin-forbidden process in bioinorganic chemistry, because the initial, "deoxy" iron complex has a high-spin ground state.	Iron	117-121	spindlin 1	Homo sapiens	149-153
15471345-1	2004	The reaction of small ligands within the distal pocket of haem proteins such as myoglobin, to form ligated, low-spin iron complexes is an archetypal spin-forbidden process in bioinorganic chemistry, because the initial, "deoxy" iron complex has a high-spin ground state.	Iron	228-232	spindlin 1	Homo sapiens	112-116
15471345-1	2004	The reaction of small ligands within the distal pocket of haem proteins such as myoglobin, to form ligated, low-spin iron complexes is an archetypal spin-forbidden process in bioinorganic chemistry, because the initial, "deoxy" iron complex has a high-spin ground state.	Iron	228-232	spindlin 1	Homo sapiens	149-153
15471345-1	2004	The reaction of small ligands within the distal pocket of haem proteins such as myoglobin, to form ligated, low-spin iron complexes is an archetypal spin-forbidden process in bioinorganic chemistry, because the initial, "deoxy" iron complex has a high-spin ground state.	Iron	228-232	spindlin 1	Homo sapiens	149-153
14675167-0	2004	The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain.	Iron	69-73	RoBo-1	Rattus norvegicus	60-64
14675167-9	2004	Neuronal expression of transferrin receptors and DMT1 in adult rats implies that neurones at this age acquire iron by receptor-mediated endocytosis of transferrin followed by iron transport out of endosomes mediated by DMT1.	Iron	110-114	RoBo-1	Rattus norvegicus	49-53
14675167-10	2004	The existence of the mutated DMT1 molecule in neurones suggests that the low cerebral iron uptake in b/b rats derives from a reduced neuronal uptake rather than an impaired iron transport through the blood-brain barrier.	Iron	86-90	RoBo-1	Rattus norvegicus	29-33
14675167-10	2004	The existence of the mutated DMT1 molecule in neurones suggests that the low cerebral iron uptake in b/b rats derives from a reduced neuronal uptake rather than an impaired iron transport through the blood-brain barrier.	Iron	173-177	RoBo-1	Rattus norvegicus	29-33
14704284-3	2004	A lack of hepcidin expression has been associated with iron overload and overexpression of hepcidin results in iron-deficiency anemia in mice.	Iron	55-59	hepcidin antimicrobial peptide	Mus musculus	10-18
14704284-4	2004	In addition, hepcidin levels decrease in mice fed a low iron diet and increase in mice fed a high iron diet.	Iron	56-60	hepcidin antimicrobial peptide	Mus musculus	13-21
14704284-4	2004	In addition, hepcidin levels decrease in mice fed a low iron diet and increase in mice fed a high iron diet.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	13-21
14704284-8	2004	In addition, hepcidin is decreased in HFE knockout mice, which demonstrates characteristics of iron overload as in hemochromatosis patients.	Iron	95-99	hepcidin antimicrobial peptide	Mus musculus	13-21
14704284-8	2004	In addition, hepcidin is decreased in HFE knockout mice, which demonstrates characteristics of iron overload as in hemochromatosis patients.	Iron	95-99	homeostatic iron regulator	Mus musculus	38-41
15013295-12	2004	Among patients with CRP levels &lt;0.3 mg/L or AAP levels &lt;6.4 mg/L, the relation between parameters of iron state was more robust.	Iron	107-111	serpin family F member 2	Homo sapiens	47-50
14744017-2	2003	Using a mini-Tn mutagenized yeast pool, we isolated a chromate-tolerant mutant, CrT9, that displayed metal-specific tolerance since it was only tolerant to Cr(VI), not to Cr(III), Cd, As, or Fe.	Iron	191-193	thymidylate synthase	Saccharomyces cerevisiae S288C	80-84
12954629-6	2003	Production in the ftr1delta strain of an iron-uptake negative Ftr1p mutant, Ftr1p(RAGLA), suppressed this copper sensitivity.	Iron	41-45	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	62-67
12954629-6	2003	Production in the ftr1delta strain of an iron-uptake negative Ftr1p mutant, Ftr1p(RAGLA), suppressed this copper sensitivity.	Iron	41-45	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	76-81
14642817-1	2003	In this work, the effect of Fenton reaction on two elastin cross-linked amino acids, desmosine (DES) and isodesmosine (IDE), in the absence or presence of different wavelength radiations generated from artificial sources has been evaluated using LC/ESI-MS. Irradiation as well as incubation of DES or IDE solutions in the presence of Fe(2+) and H(2)O(2) resulted in products with m/z 497.1 and 481.1 for [M+H](+).	Iron	28-30	elastin	Homo sapiens	51-58
12928433-6	2003	We demonstrated that under heme-depleted conditions, Aft1p-GFP was able to cycle normally between the nucleus and cytosol in response to cytosolic iron.	Iron	147-151	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	53-58
12928433-7	2003	Despite the inability to induce transcription under low iron conditions, chromatin immunoprecipitation demonstrated that Aft1p binds to the FET3 promoter in the absence of heme.	Iron	56-60	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	121-126
12842821-5	2003	However, iron/ascorbate-mediated lipid peroxidation promoted inhibitor-kappaB degradation and NF-kappaB activation, as well as gave rise to IL-8, cyclooxygenase-2, and ICAM-1.	Iron	9-13	intercellular adhesion molecule 1	Homo sapiens	168-174
12921533-1	2003	Hephaestin is a mammalian gene that encodes a predicted multicopper oxidase required for intestinal iron export.	Iron	100-104	hephaestin	Homo sapiens	0-10
12921533-4	2003	Expression of full-length hephaestin could complement the low-iron growth phenotype of a Delta fet3 strain.	Iron	62-66	hephaestin	Homo sapiens	26-36
12921533-6	2003	Expression of hephaestin in Delta fet3 cells led to an increase in both iron transport and oxidase activity.	Iron	72-76	hephaestin	Homo sapiens	14-24
12921533-9	2003	Inhibition of endocytosis or deletion of both the vacuolar iron transporters ( SMF3 and FET5 / FTH1 ) prevented hephaestin from complementing the low-iron growth phenotype of Delta fet3 cells, suggesting that hephaestin is functioning within the endocytic apparatus.	Iron	59-63	hephaestin	Homo sapiens	112-122
14600837-0	2003	Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1alpha and -1beta in the rat carotid body and glomus cells.	Iron	37-41	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	55-97
14600837-7	2003	Hydroxylation of HIF-1alpha by prolyl hydroxylase for proteasomal degradation was dependent on iron, 2-oxoglutarate, and oxygen concentration.	Iron	95-99	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	17-27
14600837-9	2003	Thus, chelation of intracellular labile iron by CPX in Nx significantly increased HIF-1alpha in CB glomus cells.	Iron	40-44	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	82-92
12868958-0	2003	Zinc suppresses the iron-accumulation phenotype of Saccharomyces cerevisiae lacking the yeast frataxin homologue (Yfh1).	Iron	20-24	ferroxidase	Saccharomyces cerevisiae S288C	114-118
12868958-3	2003	Cells lacking the yeast frataxin homologue Yfh1 accumulate large amounts of iron in their mitochondria.	Iron	76-80	ferroxidase	Saccharomyces cerevisiae S288C	43-47
12868958-6	2003	It prevented the accumulation of iron in the mitochondria of Delta yfh1 cells and increased the growth rate of these cells and their resistance to oxidative stress.	Iron	33-37	ferroxidase	Saccharomyces cerevisiae S288C	67-71
14510961-1	2003	The effect of Hfe (haemochromatosis) gene deletion on the hypoxic response of iron absorption was investigated.	Iron	78-82	homeostatic iron regulator	Mus musculus	14-17
14510961-2	2003	Hfe knock-out mice were exposed to 0.5 atmospheres hypoxia for 3 d before in vivo iron absorption was measured.	Iron	82-86	homeostatic iron regulator	Mus musculus	0-3
14510961-3	2003	Both wild-type and Hfe knock-out mice had similar (two- to threefold) increases in iron absorption in response to hypoxia.	Iron	83-87	homeostatic iron regulator	Mus musculus	19-22
14510961-5	2003	The data further support the hypothesis that at least two independent mechanisms for the regulation of iron absorption exist, only one of which requires Hfe.	Iron	103-107	homeostatic iron regulator	Mus musculus	153-156
13678672-6	2003	In contrast, trkB antisense oligonucleotides and inhibitors of Trk tyrosine kinase blocked BDNF-triggered neuronal death as well as BDNF potentiation of iron-induced oxidative neuronal necrosis, suggesting a critical role for TrkB in this phenomenon.	Iron	153-157	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	13-17
12840010-2	2003	HMX1 is also transcribed under conditions of iron deprivation and is under the control of the major iron-dependent transcription factor, Aft1p.	Iron	45-49	Hmx1p	Saccharomyces cerevisiae S288C	0-4
12840010-2	2003	HMX1 is also transcribed under conditions of iron deprivation and is under the control of the major iron-dependent transcription factor, Aft1p.	Iron	100-104	Hmx1p	Saccharomyces cerevisiae S288C	0-4
12840010-2	2003	HMX1 is also transcribed under conditions of iron deprivation and is under the control of the major iron-dependent transcription factor, Aft1p.	Iron	100-104	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	137-142
12840010-5	2003	Hmx1p facilitates the capacity of cells to use heme as a nutritional iron source.	Iron	69-73	Hmx1p	Saccharomyces cerevisiae S288C	0-5
12840010-6	2003	Deletion of HMX1 leads to defects in iron accumulation and to expansion of intracellular heme pools.	Iron	37-41	Hmx1p	Saccharomyces cerevisiae S288C	12-16
12840010-7	2003	These alterations in the regulatory pools of iron lead to activation of Aft1p and inappropriate activation of heme-dependent transcription factors.	Iron	45-49	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	72-77
12840010-9	2003	Hmx1p promotes both the reutilization of heme iron and the regulation of heme-dependent transcription during periods of iron scarcity.	Iron	46-50	Hmx1p	Saccharomyces cerevisiae S288C	0-5
12840010-9	2003	Hmx1p promotes both the reutilization of heme iron and the regulation of heme-dependent transcription during periods of iron scarcity.	Iron	120-124	Hmx1p	Saccharomyces cerevisiae S288C	0-5
12970193-0	2003	Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p.	Iron	51-55	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	96-101
12970193-1	2003	The mitochondrial proteins Isu1p and Isu2p play an essential role in the maturation of cellular iron-sulfur (Fe/S) proteins in eukaryotes.	Iron	109-111	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	27-32
12970193-1	2003	The mitochondrial proteins Isu1p and Isu2p play an essential role in the maturation of cellular iron-sulfur (Fe/S) proteins in eukaryotes.	Iron	109-111	putative iron-binding protein ISU2	Saccharomyces cerevisiae S288C	37-42
12750164-0	2003	Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane.	Iron	0-4	natural resistance-associated macrophage protein 2	Cricetulus griseus	70-77
14505074-3	2003	At neutral pH the frequencies of the nu(3) mode indicate that a pure five-coordinate heme iron exists in C cP(MI) whereas a six-coordinate low-spin iron is the dominant species in the C cP variants with the engineered Mn(II) binding site.	Iron	90-94	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	105-109
14505074-3	2003	At neutral pH the frequencies of the nu(3) mode indicate that a pure five-coordinate heme iron exists in C cP(MI) whereas a six-coordinate low-spin iron is the dominant species in the C cP variants with the engineered Mn(II) binding site.	Iron	148-152	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	184-188
14535313-9	2003	Despite problems encountered with CH3COOH, pilot-scale treatment of Soil B (12 100 mg RDX kg(-1)) with Fe(0) or Fe(0) + Al2(SO4)3 showed high RDX destruction (96-98%).	Iron	112-114	radixin	Homo sapiens	142-145
14535313-10	2003	This indicates that RDX-contaminated soil can be remediated at the field scale with Fe(0) and soil-specific problems (i.e., alkalinity, high organic matter or Ba) can be overcome by adjustments to the Fe(0) treatment.	Iron	84-89	radixin	Homo sapiens	20-23
14535313-10	2003	This indicates that RDX-contaminated soil can be remediated at the field scale with Fe(0) and soil-specific problems (i.e., alkalinity, high organic matter or Ba) can be overcome by adjustments to the Fe(0) treatment.	Iron	201-206	radixin	Homo sapiens	20-23
18969144-6	2003	The method was successfully applied to the analyses of copper and iron in tap, well, river and pond waters.	Iron	66-70	nuclear RNA export factor 1	Homo sapiens	74-77
12663437-3	2003	Evidence from transgenic mouse models indicates that hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from macrophages.	Iron	103-107	hepcidin antimicrobial peptide	Mus musculus	53-61
12663437-3	2003	Evidence from transgenic mouse models indicates that hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from macrophages.	Iron	143-147	hepcidin antimicrobial peptide	Mus musculus	53-61
12663437-3	2003	Evidence from transgenic mouse models indicates that hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from macrophages.	Iron	143-147	hepcidin antimicrobial peptide	Mus musculus	53-61
12875842-8	2003	We demonstrate that over-expression of MDL1 in Deltaatm1 cells results in a reduction of mitochondrial iron content, and decreased sensitivity to H(2)O(2) and transition metal toxicity.	Iron	103-107	ATP-binding cassette permease MDL1	Saccharomyces cerevisiae S288C	39-43
12895262-5	2003	RESULTS: Hepatic iron overload was associated with induction of heme oxygenase-1, a sensitive indicator of oxidative stress, and with modest increases in hydroxyproline and procollagen I mRNA levels without histologically evident fibrosis, all of which were unaffected by dietary fat.	Iron	17-21	heme oxygenase 1	Rattus norvegicus	64-80
14627119-4	2003	In contrast, 24p3/Ngal targets early progenitors at the kidney"s periphery through an iron-mediated, but a transferrin-independent mechanism.	Iron	86-90	lipocalin 2	Homo sapiens	18-22
12756250-0	2003	Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements.	Iron	24-28	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-5
12826281-2	2003	Unlike many other iron-sulfur clusters, the [4Fe-4S] cluster of endonuclease III is stable and resistant to both oxidation and reduction.	Iron	18-22	endonuclease III	Escherichia coli	64-80
12850887-5	2003	The central question addressed in this paper is whether the thickening properties of locust bean gum affect the availability of calcium, iron, and zinc.	Iron	137-141	brain expressed associated with NEDD4 1	Homo sapiens	92-96
12850887-15	2003	From this experimental set-up it appears that locust bean gum influences calcium availability in infant formulas by means of its physical properties to act as thickening agent, rather than its chemical ability to form complexes as demonstrated earlier with respect to iron and zinc.	Iron	268-272	brain expressed associated with NEDD4 1	Homo sapiens	53-57
14509218-1	2003	We showed that the content of reticulocyte hemoglobin (CHr) is a reliable measure of iron status with regard to erythrocytopoiesis in chronic dialysis status.	Iron	85-89	chromate resistance; sulfate transport	Homo sapiens	55-58
14509218-3	2003	We aimed to utilize the measurement of CHr levels to monitor iron status in clinical practice.	Iron	61-65	chromate resistance; sulfate transport	Homo sapiens	39-42
12850285-3	2003	Hemopexin is an essential heme scavenger produced primarily in the liver, which upon binding to free heme, transports it to the liver where the heme iron is re-utilized.	Iron	149-153	hemopexin	Rattus norvegicus	0-9
12781777-4	2003	Keeping the iron at a constant concentration and varying the Ca2+ level changed the mitochondrial Ca2+ retention times, but not the amount of MDA formation.	Iron	12-16	carbonic anhydrase 2	Homo sapiens	98-101
12576298-2	2003	One potential candidate for such transferrin-independent uptake of iron is divalent metal transporter-1 (DMT1), an established iron transporter.	Iron	67-71	transferrin	Mus musculus	33-44
12805609-1	2003	Regulation of the root high-affinity iron uptake system by whole-plant signals was investigated at the molecular level in Arabidopsis, through monitoring FRO2 and IRT1 gene expression.	Iron	37-41	iron-regulated transporter 1	Arabidopsis thaliana	163-167
12805609-4	2003	Split-root experiments show that the expression of IRT1 and FRO2 is controlled both by a local induction from the root iron pool and through a systemic pathway involving a shoot-borne signal, both signals being integrated to tightly control production of the root iron uptake proteins.	Iron	119-123	iron-regulated transporter 1	Arabidopsis thaliana	51-55
12805609-4	2003	Split-root experiments show that the expression of IRT1 and FRO2 is controlled both by a local induction from the root iron pool and through a systemic pathway involving a shoot-borne signal, both signals being integrated to tightly control production of the root iron uptake proteins.	Iron	264-268	iron-regulated transporter 1	Arabidopsis thaliana	51-55
12805609-7	2003	On the basis of the new molecular insights provided in this study and given the strict coregulation of IRT1 and FRO2 observed, we present a model of local and long-distance regulation of the root iron uptake system in Arabidopsis.	Iron	196-200	iron-regulated transporter 1	Arabidopsis thaliana	103-107
12706501-1	2003	The HFE mutation is common and, when homozygous, can lead to a morbid accumulation of body iron and the disease hereditary hemochromatosis.	Iron	91-95	homeostatic iron regulator	Mus musculus	4-7
12706501-3	2003	Dietary iron content was hypothesized to interact with the HFE genotype to influence oxidative damage in mammary and colon tissue.	Iron	8-12	homeostatic iron regulator	Mus musculus	59-62
12706501-6	2003	These results suggest that dietary modification may affect the course of iron overload from HFE mutations.	Iron	73-77	homeostatic iron regulator	Mus musculus	92-95
12704390-10	2003	We found unexpected alterations in the expression of Slc39a1 (mouse ortholog of SLC11A3) and Cybrd1, which encode key iron transport proteins, and Hamp (hepcidin antimicrobial peptide), a hepatic regulator of iron transport.	Iron	209-213	hepcidin antimicrobial peptide	Mus musculus	153-183
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	128-132	iron responsive element binding protein 2	Rattus norvegicus	164-169
12621119-2	2003	The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15.	Iron	128-132	iron responsive element binding protein 2	Rattus norvegicus	164-169
12729727-3	2003	We report a novel heterologous system for the expression of catalytically active iron-containing NI1 NHase in Escherichia coli, involving coexpression with the E. coli GroES and GroEL chaperones.	Iron	81-85	chaperonin GroES	Escherichia coli	168-173
12584192-7	2003	Concomitantly, Fes(act) down-regulated the macrophage marker F4/80, suggesting that the biological activity of Fes was coordinated in a lineage-specific manner.	Iron	15-18	adhesion G protein-coupled receptor E1	Mus musculus	61-66
12584192-7	2003	Concomitantly, Fes(act) down-regulated the macrophage marker F4/80, suggesting that the biological activity of Fes was coordinated in a lineage-specific manner.	Iron	111-114	adhesion G protein-coupled receptor E1	Mus musculus	61-66
12641613-1	2003	Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK.	Iron	8-12	surfactant protein A2	Homo sapiens	0-3
12631660-0	2003	Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding.	Iron	65-69	homeostatic iron regulator	Mus musculus	44-47
12848292-1	2003	Early experiments and molecular simulations of PUFA favored a rigid arrangement of double bonds in U-shaped or extended conformations such as angle-iron or helical.	Iron	148-152	pumilio RNA binding family member 3	Homo sapiens	47-51
12606179-7	2003	Similarly, we noted a decrease in Hamp expression in iron-loaded Hfe-knockout mice.	Iron	53-57	hepcidin antimicrobial peptide	Mus musculus	34-38
12606179-7	2003	Similarly, we noted a decrease in Hamp expression in iron-loaded Hfe-knockout mice.	Iron	53-57	homeostatic iron regulator	Mus musculus	65-68
12548710-1	2003	Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin.	Iron	174-178	heme oxygenase 1	Rattus norvegicus	0-16
12548710-1	2003	Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin.	Iron	174-178	heme oxygenase 1	Rattus norvegicus	18-21
12548710-1	2003	Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin.	Iron	174-178	cytochrome p450 oxidoreductase	Rattus norvegicus	80-111
12538076-1	2003	Stearoyl-CoA desaturase (SCD) is a short-lived, polytopic membrane-bound non-heme iron enzyme localized primarily in the endoplasmic reticulum.	Iron	82-86	stearoyl-CoA desaturase	Homo sapiens	0-23
12538076-1	2003	Stearoyl-CoA desaturase (SCD) is a short-lived, polytopic membrane-bound non-heme iron enzyme localized primarily in the endoplasmic reticulum.	Iron	82-86	stearoyl-CoA desaturase	Homo sapiens	25-28
12499347-0	2003	Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: a randomized controlled study in Colombo, Sri Lanka.	Iron	0-4	sorcin	Homo sapiens	170-173
12880182-3	2003	Yfh1p appears to regulate mitochondrial iron homeostasis and protect from free radical toxicity.	Iron	40-44	ferroxidase	Saccharomyces cerevisiae S288C	0-5
12946050-5	2003	The regulation of cellular iron metabolism has been further enhanced by the recent discovery of two iron regulatory proteins, IRP1 and IRP2 which control the level of iron with in the cell.	Iron	27-31	aconitase 1	Mus musculus	126-130
12946050-5	2003	The regulation of cellular iron metabolism has been further enhanced by the recent discovery of two iron regulatory proteins, IRP1 and IRP2 which control the level of iron with in the cell.	Iron	27-31	iron responsive element binding protein 2	Mus musculus	135-139
12946050-5	2003	The regulation of cellular iron metabolism has been further enhanced by the recent discovery of two iron regulatory proteins, IRP1 and IRP2 which control the level of iron with in the cell.	Iron	100-104	aconitase 1	Mus musculus	126-130
12946050-5	2003	The regulation of cellular iron metabolism has been further enhanced by the recent discovery of two iron regulatory proteins, IRP1 and IRP2 which control the level of iron with in the cell.	Iron	100-104	iron responsive element binding protein 2	Mus musculus	135-139
12946050-5	2003	The regulation of cellular iron metabolism has been further enhanced by the recent discovery of two iron regulatory proteins, IRP1 and IRP2 which control the level of iron with in the cell.	Iron	100-104	aconitase 1	Mus musculus	126-130
12946050-5	2003	The regulation of cellular iron metabolism has been further enhanced by the recent discovery of two iron regulatory proteins, IRP1 and IRP2 which control the level of iron with in the cell.	Iron	100-104	iron responsive element binding protein 2	Mus musculus	135-139
12946050-6	2003	When the cellular level of iron increases IRP2 is degraded by ubiquitination and no further iron accumulates.	Iron	27-31	iron responsive element binding protein 2	Mus musculus	42-46
12946050-8	2003	Knock-out IRP1 and IRP2 mice have shown that in latter mice brain iron accumulation precedes the neurodegeneration, ataxia and bradykinesia observed in these animals.	Iron	66-70	aconitase 1	Mus musculus	10-14
12946050-8	2003	Knock-out IRP1 and IRP2 mice have shown that in latter mice brain iron accumulation precedes the neurodegeneration, ataxia and bradykinesia observed in these animals.	Iron	66-70	iron responsive element binding protein 2	Mus musculus	19-23
12946050-9	2003	Indeed MPTP treatment, which results in iron accumulation in SNCP, abolishes IRP2 with the concomitant increase in alpha-synuclein.	Iron	40-44	iron responsive element binding protein 2	Mus musculus	77-81
12946050-10	2003	Iron chelators such as R-apomorphine and EGCG, which protect against MPTP neurotoxicity, prevent the loss of IRP2 and the increase in alpha-synuclein.	Iron	0-4	iron responsive element binding protein 2	Mus musculus	109-113
12613041-2	2002	To this end solvated salts MX2 (M = Fe, Ni, and Cr) were treated with a ligand that consisted of two doubly silyl-bridged cyclopentadienyl anions.	Iron	36-38	MX dynamin like GTPase 2	Homo sapiens	27-30
12547225-7	2002	Dcytb, the iron regulated ferric reductase may also utilize cytoplasmic ascorbate as electron donor for transmembrane reduction of iron.	Iron	11-15	cytochrome b reductase 1	Homo sapiens	0-5
12547225-8	2002	Dcytb expression was found in other tissues apart from the duodenum and its regulation and functions at these other sites are of interest in iron metabolism.	Iron	141-145	cytochrome b reductase 1	Homo sapiens	0-5
12547226-1	2002	Hepcidin is a circulating antimicrobial peptide which has been proposed to regulate the uptake of dietary iron and its storage in reticuloendothelial macrophages.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	0-8
12547226-2	2002	Transgenic mice lacking hepcidin expression demonstrate abnormalities of iron homeostasis similar to Hfe knockout mice and to patients with HFE-associated hereditary hemochromatosis (HH).	Iron	73-77	hepcidin antimicrobial peptide	Mus musculus	24-32
12547226-6	2002	The decreased hepcidin expression was associated with hepatic iron deposition, elevated transferrin saturations, and decreased splenic iron concentrations.	Iron	62-66	hepcidin antimicrobial peptide	Mus musculus	14-22
12547226-6	2002	The decreased hepcidin expression was associated with hepatic iron deposition, elevated transferrin saturations, and decreased splenic iron concentrations.	Iron	135-139	hepcidin antimicrobial peptide	Mus musculus	14-22
12547226-8	2002	Placing 8 week-old wild type and Hfe knockout mice on a 2% carbonyl iron diet for 2 weeks led to a similar degree of hepatic iron loading in each group.	Iron	125-129	homeostatic iron regulator	Mus musculus	33-36
12547226-10	2002	The lack of an increase in liver hepcidin expression in these iron-loaded Hfe knockout mice was associated with sparing of iron deposition into the spleen.	Iron	62-66	homeostatic iron regulator	Mus musculus	74-77
12547226-11	2002	These data indicate that the normal relationship between body iron stores and liver hepcidin mRNA levels is altered in Hfe knockout mice, such that liver hepcidin expression is relatively decreased.	Iron	62-66	homeostatic iron regulator	Mus musculus	119-122
12547229-2	2002	It has been proposed that the efficiency of absorption is determined by the amount of iron acquired by developing enterocytes when they are in the crypts of Lieberkuhn and that this regulates expression of iron transporters such as DMT1 in mature enterocytes of the intestinal villi.	Iron	86-90	RoBo-1	Rattus norvegicus	232-236
12433162-8	2002	These observations suggest that the faster 1,1,1-TCA transformation in the combined systems (compared to the FeS-alone and LEC-alone experiments) is due to increased reactivity of both FeS and LEC, possibly due to production of soluble microbial products that make the FeS more reactive or less inhibition of LEC by 1,1,1-TCA due to FeS transformation of 1,1,1-TCA.	Iron	109-112	C-C motif chemokine ligand 16	Homo sapiens	193-196
12433162-8	2002	These observations suggest that the faster 1,1,1-TCA transformation in the combined systems (compared to the FeS-alone and LEC-alone experiments) is due to increased reactivity of both FeS and LEC, possibly due to production of soluble microbial products that make the FeS more reactive or less inhibition of LEC by 1,1,1-TCA due to FeS transformation of 1,1,1-TCA.	Iron	109-112	C-C motif chemokine ligand 16	Homo sapiens	193-196
12433162-8	2002	These observations suggest that the faster 1,1,1-TCA transformation in the combined systems (compared to the FeS-alone and LEC-alone experiments) is due to increased reactivity of both FeS and LEC, possibly due to production of soluble microbial products that make the FeS more reactive or less inhibition of LEC by 1,1,1-TCA due to FeS transformation of 1,1,1-TCA.	Iron	185-188	C-C motif chemokine ligand 16	Homo sapiens	123-126
12433162-8	2002	These observations suggest that the faster 1,1,1-TCA transformation in the combined systems (compared to the FeS-alone and LEC-alone experiments) is due to increased reactivity of both FeS and LEC, possibly due to production of soluble microbial products that make the FeS more reactive or less inhibition of LEC by 1,1,1-TCA due to FeS transformation of 1,1,1-TCA.	Iron	185-188	C-C motif chemokine ligand 16	Homo sapiens	123-126
12433162-8	2002	These observations suggest that the faster 1,1,1-TCA transformation in the combined systems (compared to the FeS-alone and LEC-alone experiments) is due to increased reactivity of both FeS and LEC, possibly due to production of soluble microbial products that make the FeS more reactive or less inhibition of LEC by 1,1,1-TCA due to FeS transformation of 1,1,1-TCA.	Iron	185-188	C-C motif chemokine ligand 16	Homo sapiens	123-126
12489503-0	2002	The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease.	Iron	24-28	hepcidin antimicrobial peptide	Mus musculus	12-20
12489503-4	2002	Evidence to date indicates that hepcidin is a negative regulator of intestinal iron absorption, placental iron transport, and the release of iron from macrophages that recycle iron from senescent red cells.	Iron	79-83	hepcidin antimicrobial peptide	Mus musculus	32-40
12489503-4	2002	Evidence to date indicates that hepcidin is a negative regulator of intestinal iron absorption, placental iron transport, and the release of iron from macrophages that recycle iron from senescent red cells.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	32-40
12489503-4	2002	Evidence to date indicates that hepcidin is a negative regulator of intestinal iron absorption, placental iron transport, and the release of iron from macrophages that recycle iron from senescent red cells.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	32-40
12489503-4	2002	Evidence to date indicates that hepcidin is a negative regulator of intestinal iron absorption, placental iron transport, and the release of iron from macrophages that recycle iron from senescent red cells.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	32-40
12453412-0	2002	The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.	Iron	98-102	lipocalin 2	Homo sapiens	25-29
12453412-4	2002	Here we report that NGAL tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent in iron-limiting conditions.	Iron	200-204	lipocalin 2	Homo sapiens	20-24
12453412-5	2002	We therefore propose that NGAL participates in the antibacterial iron depletion strategy of the innate immune system.	Iron	65-69	lipocalin 2	Homo sapiens	26-30
12453413-2	2002	We show that a member of the lipocalin superfamily (24p3/Ngal) delivers iron to the cytoplasm where it activates or represses iron-responsive genes.	Iron	72-76	lipocalin 2	Homo sapiens	57-61
12453413-2	2002	We show that a member of the lipocalin superfamily (24p3/Ngal) delivers iron to the cytoplasm where it activates or represses iron-responsive genes.	Iron	126-130	lipocalin 2	Homo sapiens	57-61
12453413-3	2002	Iron unloading depends on the cycling of 24p3/Ngal through acidic endosomes, but its pH sensitivity and its subcellular targeting differed from transferrin.	Iron	0-4	lipocalin 2	Homo sapiens	46-50
12106773-0	2002	Influence of iron-saturation of plasma transferrin in iron distribution in the brain.	Iron	13-17	transferrin	Mus musculus	39-50
12106773-0	2002	Influence of iron-saturation of plasma transferrin in iron distribution in the brain.	Iron	54-58	transferrin	Mus musculus	39-50
12106773-1	2002	Based on the evidence that iron distribution in the peripheral tissues is changed by iron-saturation of plasma transferrin, the influence of iron-saturation of plasma transferrin in iron delivery to the brain was examined.	Iron	27-31	transferrin	Mus musculus	111-122
12106773-1	2002	Based on the evidence that iron distribution in the peripheral tissues is changed by iron-saturation of plasma transferrin, the influence of iron-saturation of plasma transferrin in iron delivery to the brain was examined.	Iron	85-89	transferrin	Mus musculus	111-122
12106773-1	2002	Based on the evidence that iron distribution in the peripheral tissues is changed by iron-saturation of plasma transferrin, the influence of iron-saturation of plasma transferrin in iron delivery to the brain was examined.	Iron	85-89	transferrin	Mus musculus	111-122
12106773-1	2002	Based on the evidence that iron distribution in the peripheral tissues is changed by iron-saturation of plasma transferrin, the influence of iron-saturation of plasma transferrin in iron delivery to the brain was examined.	Iron	85-89	transferrin	Mus musculus	111-122
12106773-3	2002	Peak retention time of (59)Fe was transferred from the retention time of transferrin to that of mercaptalbumin, suggesting that iron may bind to albumin in the plasma in the case of iron-saturation of transferrin.	Iron	27-29	transferrin	Mus musculus	73-84
12106773-3	2002	Peak retention time of (59)Fe was transferred from the retention time of transferrin to that of mercaptalbumin, suggesting that iron may bind to albumin in the plasma in the case of iron-saturation of transferrin.	Iron	27-29	transferrin	Mus musculus	201-212
12106773-3	2002	Peak retention time of (59)Fe was transferred from the retention time of transferrin to that of mercaptalbumin, suggesting that iron may bind to albumin in the plasma in the case of iron-saturation of transferrin.	Iron	128-132	transferrin	Mus musculus	73-84
12106773-3	2002	Peak retention time of (59)Fe was transferred from the retention time of transferrin to that of mercaptalbumin, suggesting that iron may bind to albumin in the plasma in the case of iron-saturation of transferrin.	Iron	128-132	transferrin	Mus musculus	201-212
12106773-3	2002	Peak retention time of (59)Fe was transferred from the retention time of transferrin to that of mercaptalbumin, suggesting that iron may bind to albumin in the plasma in the case of iron-saturation of transferrin.	Iron	182-186	transferrin	Mus musculus	73-84
12106773-3	2002	Peak retention time of (59)Fe was transferred from the retention time of transferrin to that of mercaptalbumin, suggesting that iron may bind to albumin in the plasma in the case of iron-saturation of transferrin.	Iron	182-186	transferrin	Mus musculus	201-212
12106773-7	2002	These results suggest that the fraction of non-transferrin-bound iron is engulfed by the liver, resulting in the reduction of iron available for iron delivery to the brain in iron-loaded mice.	Iron	65-69	transferrin	Mus musculus	47-58
12106773-7	2002	These results suggest that the fraction of non-transferrin-bound iron is engulfed by the liver, resulting in the reduction of iron available for iron delivery to the brain in iron-loaded mice.	Iron	126-130	transferrin	Mus musculus	47-58
12106773-7	2002	These results suggest that the fraction of non-transferrin-bound iron is engulfed by the liver, resulting in the reduction of iron available for iron delivery to the brain in iron-loaded mice.	Iron	126-130	transferrin	Mus musculus	47-58
12106773-7	2002	These results suggest that the fraction of non-transferrin-bound iron is engulfed by the liver, resulting in the reduction of iron available for iron delivery to the brain in iron-loaded mice.	Iron	126-130	transferrin	Mus musculus	47-58
12106773-8	2002	Transferrin-bound iron may be responsible for the fraction of iron in circulation that enters the brain.	Iron	18-22	transferrin	Mus musculus	0-11
12106773-8	2002	Transferrin-bound iron may be responsible for the fraction of iron in circulation that enters the brain.	Iron	62-66	transferrin	Mus musculus	0-11
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	119-123	iron responsive element binding protein 2	Mus musculus	155-159
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	119-123	ferritin heavy polypeptide 1	Mus musculus	165-175
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	239-243	iron responsive element binding protein 2	Mus musculus	155-159
12110671-3	2002	Wu and colleagues (Wu, K.-J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679) showed converse control of iron regulatory protein expression (IRP2) and H-ferritin by c-Myc, suggesting a role for c-Myc in enhancing cytoplasmic iron levels for growth.	Iron	239-243	ferritin heavy polypeptide 1	Mus musculus	165-175
12206893-4	2002	The most likely rate-limiting step is the cytochrome b redox state governed movement of the head domain of iron-sulfur protein from its electron-accepting site ("fixed" or "b-state" position) to its electron donating site ("c(1)-state" position).	Iron	107-111	mitochondrially encoded cytochrome b	Homo sapiens	42-54
12183576-9	2002	These results suggest that siderophore uptake by Sit1p/Arn1p is required in a specific process of C. albicans infection, namely epithelial invasion and penetration, while in the blood or within organs other sources of iron, including heme, may be used.	Iron	218-222	siderophore transporter	Saccharomyces cerevisiae S288C	55-60
12196168-1	2002	The budding yeast Saccharomyces cerevisiae responds to growth in limiting amounts of iron by activating the transcription factor Aft1p and expressing a set of genes that ameliorate the effects of iron deprivation.	Iron	85-89	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	129-134
12196168-2	2002	Analysis of iron-regulated gene expression using cDNA microarrays has revealed the set of genes controlled by iron and Aft1p.	Iron	12-16	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	119-124
12196176-2	2002	Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1).	Iron	89-93	cytochrome b reductase 1	Homo sapiens	0-5
12196177-2	2002	We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response.	Iron	108-112	RoBo-1	Rattus norvegicus	133-161
12236996-2	2002	MATERIALS AND METHODS: Transferrin binding complexes (TbpA/B) purified from a TbpB isotype II Neisseria meningitidis strain were used to obtain sera with five different adjuvant formulations in mice in order to test the effect of the adjuvant on the ability of specific anti-TbpA/B antibodies to block transferrin binding, iron uptake and growth by meningococci.	Iron	323-327	transferrin	Mus musculus	23-34
12190960-7	2002	After 3 months of iron-rich feeding duodenal 59Fe absorption decreased to approximately 15% of iron-adequate controls but remained about twice as high in HFE(o/o) as in HFE(+/+) mice.	Iron	18-22	homeostatic iron regulator	Mus musculus	154-157
12190960-7	2002	After 3 months of iron-rich feeding duodenal 59Fe absorption decreased to approximately 15% of iron-adequate controls but remained about twice as high in HFE(o/o) as in HFE(+/+) mice.	Iron	18-22	homeostatic iron regulator	Mus musculus	169-172
12117961-7	2002	The shp gene was cotranscribed with eight contiguous genes, including homologues of an ABC transporter involved in iron uptake in gram-negative bacteria.	Iron	115-119	nuclear receptor subfamily 0, group B, member 2	Mus musculus	4-7
12151624-2	2002	The depletion of Fe upregulates the expression of divalent metal transporter 1 (DMT1), which is located at the apical membrane of enterocytes lining the small intestine.	Iron	17-19	RoBo-1	Rattus norvegicus	50-78
12151624-2	2002	The depletion of Fe upregulates the expression of divalent metal transporter 1 (DMT1), which is located at the apical membrane of enterocytes lining the small intestine.	Iron	17-19	RoBo-1	Rattus norvegicus	80-84
12151624-3	2002	DMT1 has been shown to transport Fe and other divalent metal ions in vitro.	Iron	33-35	RoBo-1	Rattus norvegicus	0-4
12151624-12	2002	The levels of DMT1 mRNA were significantly lower in kidney and liver than in duodenum, but were 30 and 40% higher, respectively, in rats fed the FeD diet than in rats fed the FeS diet.	Iron	175-178	RoBo-1	Rattus norvegicus	14-18
12151624-13	2002	These findings suggest that functional DMT1 protein is likely upregulated in the small intestine at the mRNA level by body iron depletion and increases Cd uptake from the gastrointestinal tract with subsequent transfer of Cd to the circulation and body tissues.	Iron	123-127	RoBo-1	Rattus norvegicus	39-43
12151624-14	2002	Furthermore, the data from this study may indicate that DMT1 is a nonspecific metal transporter, which can transport not only Fe, but probably the toxic metal as well.	Iron	126-128	RoBo-1	Rattus norvegicus	56-60
12224755-9	2002	DMT1 exists in two isoforms resulting from alternate splicing of a single gene product with one of the two mRNA species containing an iron response element (IRE) motif downstream from the stop codon.	Iron	134-138	RoBo-1	Rattus norvegicus	0-4
12224755-10	2002	The presence of the IRE provides a binding site for the iron response proteins (IRP1 and 2); binding of either of these proteins could stabilize DMT1 mRNA and would increase expression of the +IRE form of the transporter.	Iron	56-60	RoBo-1	Rattus norvegicus	145-149
12224755-11	2002	Iron and Mn compete for transport into PC12 cells via DMT1, so removal of iron from the culture media enhances Mn toxicity.	Iron	0-4	RoBo-1	Rattus norvegicus	54-58
12224755-11	2002	Iron and Mn compete for transport into PC12 cells via DMT1, so removal of iron from the culture media enhances Mn toxicity.	Iron	74-78	RoBo-1	Rattus norvegicus	54-58
12084823-0	2002	IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth.	Iron	47-51	iron-regulated transporter 1	Arabidopsis thaliana	0-4
12084823-3	2002	Here, we present genetic evidence that IRT1 is essential for the uptake of iron from the soil.	Iron	75-79	iron-regulated transporter 1	Arabidopsis thaliana	39-43
12084823-8	2002	We also show, through promoter::beta-glucuronidase analysis and in situ hybridization, that IRT1 is expressed in the external cell layers of the root, specifically in response to iron starvation.	Iron	179-183	iron-regulated transporter 1	Arabidopsis thaliana	92-96
12084824-5	2002	FRO1 was isolated through positional cloning and found to encode a protein with high similarity to the 18-kD Fe-S subunit of complex I (NADH dehydrogenase, EC 1.6.5.3) in the mitochondrial electron transfer chain.	Iron	109-113	alternative NAD(P)H dehydrogenase 1	Arabidopsis thaliana	136-154
12084831-4	2002	The Arabidopsis IRT1 gene is the major transporter responsible for high-affinity iron uptake from the soil.	Iron	81-85	iron-regulated transporter 1	Arabidopsis thaliana	16-20
12084831-5	2002	Here, we show that the steady state level of IRT1 mRNA was induced within 24 h after transfer of plants to iron-deficient conditions, with protein levels peaking 72 h after transfer.	Iron	107-111	iron-regulated transporter 1	Arabidopsis thaliana	45-49
12084831-6	2002	IRT1 mRNA and protein were undetectable 12 h after plants were shifted back to iron-sufficient conditions.	Iron	79-83	iron-regulated transporter 1	Arabidopsis thaliana	0-4
11877447-1	2002	The Aft1 transcription factor regulates the iron regulon in response to iron availability in Saccharomyces cerevisiae.	Iron	44-48	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	4-8
11877447-1	2002	The Aft1 transcription factor regulates the iron regulon in response to iron availability in Saccharomyces cerevisiae.	Iron	72-76	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	4-8
11877447-2	2002	Aft1 activates a battery of genes required for iron uptake under iron-starved conditions, whereas Aft1 function is inactivated under iron-replete conditions.	Iron	47-51	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
11877447-2	2002	Aft1 activates a battery of genes required for iron uptake under iron-starved conditions, whereas Aft1 function is inactivated under iron-replete conditions.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
11877447-2	2002	Aft1 activates a battery of genes required for iron uptake under iron-starved conditions, whereas Aft1 function is inactivated under iron-replete conditions.	Iron	65-69	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
11877447-3	2002	Previously, we have shown that iron-regulated DNA binding by Aft1 is responsible for the controlled expression of target genes.	Iron	31-35	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	61-65
11877447-4	2002	Here we show that this iron-regulated DNA binding by Aft1 is not due to the change in the total expression level of Aft1 or alteration of DNA binding activity.	Iron	23-27	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	53-57
11877447-5	2002	Rather, nuclear localization of Aft1 responds to iron status, leading to iron-regulated expression of the target genes.	Iron	49-53	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	32-36
11877447-5	2002	Rather, nuclear localization of Aft1 responds to iron status, leading to iron-regulated expression of the target genes.	Iron	73-77	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	32-36
11877447-8	2002	These results suggest that the nuclear export of Aft1 is critical for ensuring iron-responsive transcriptional activation of the Aft1 regulon and that the nuclear import/export systems are involved in iron sensing by Aft1 in S. cerevisiae.	Iron	79-83	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	49-53
11877447-8	2002	These results suggest that the nuclear export of Aft1 is critical for ensuring iron-responsive transcriptional activation of the Aft1 regulon and that the nuclear import/export systems are involved in iron sensing by Aft1 in S. cerevisiae.	Iron	79-83	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	129-133
11877447-8	2002	These results suggest that the nuclear export of Aft1 is critical for ensuring iron-responsive transcriptional activation of the Aft1 regulon and that the nuclear import/export systems are involved in iron sensing by Aft1 in S. cerevisiae.	Iron	79-83	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	129-133
11877447-8	2002	These results suggest that the nuclear export of Aft1 is critical for ensuring iron-responsive transcriptional activation of the Aft1 regulon and that the nuclear import/export systems are involved in iron sensing by Aft1 in S. cerevisiae.	Iron	201-205	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	129-133
11877447-8	2002	These results suggest that the nuclear export of Aft1 is critical for ensuring iron-responsive transcriptional activation of the Aft1 regulon and that the nuclear import/export systems are involved in iron sensing by Aft1 in S. cerevisiae.	Iron	201-205	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	129-133
12144532-5	2002	However, in recent years, findings from our group and from others showed that GGT-catalysed extracellular metabolism of GSH leads, in the presence of iron, to the generation of reactive oxygen species (ROS).	Iron	150-154	inactive glutathione hydrolase 2	Homo sapiens	78-81
12144532-8	2002	The results obtained demonstrate that the GGT/GSH/iron system oxidises isolated erythrocyte membranes.	Iron	50-54	inactive glutathione hydrolase 2	Homo sapiens	42-45
12180836-1	2002	Heme oxygenase 1 (HO-1) is an enzyme which degrades heme into tree end products: biliverdin, free iron and carbon monoxide.	Iron	98-102	heme oxygenase 1	Rattus norvegicus	0-16
12180836-1	2002	Heme oxygenase 1 (HO-1) is an enzyme which degrades heme into tree end products: biliverdin, free iron and carbon monoxide.	Iron	98-102	heme oxygenase 1	Rattus norvegicus	18-22
11955243-1	2002	The spin-dependent reflectivity of electrons with energies between 0 and 20 eV from Fe single crystals 2-8 monolayers thick on a W(110) surface is studied by spin-polarized low energy electron microscopy.	Iron	84-86	spindlin 1	Homo sapiens	4-8
11955243-2	2002	The quantum size oscillations in the reflectivity are analyzed in a similar manner as in photoemission of ground state electrons, yielding the spin-resolved unoccupied state band structure of Fe in the Gamma N direction in the energy range studied.	Iron	192-194	spindlin 1	Homo sapiens	143-147
11939775-1	2002	Ferrochelatase (EC 4.99.1.1), the terminal enzyme of the heme biosynthetic pathway, catalyzes the insertion of ferrous iron into the protoporphyrin IX ring.	Iron	111-123	ferrochelatase	Mus musculus	0-14
11969379-7	2002	The RNA-binding activity of IRP2 was selectively activated by the low iron intake and correlated with an increase of transferrin receptor mRNA, while clofibrate treatment offset the effects of the low iron intake.	Iron	70-74	iron responsive element binding protein 2	Rattus norvegicus	28-32
11969379-7	2002	The RNA-binding activity of IRP2 was selectively activated by the low iron intake and correlated with an increase of transferrin receptor mRNA, while clofibrate treatment offset the effects of the low iron intake.	Iron	201-205	iron responsive element binding protein 2	Rattus norvegicus	28-32
11796730-5	2002	The structures provide a complete picture of the electron transfer chain from NADPH to the substrate, 5-iodouracil, spanning a distance of 56 A and involving FAD, four [Fe-S] clusters, and FMN as cofactors.	Iron	169-173	2,4-dienoyl-CoA reductase 1	Homo sapiens	78-83
12002662-0	2002	The lipophilic iron compound TMH-ferrocene [(3,5,5-trimethylhexanoyl)ferrocene] increases iron concentrations, neuronal L-ferritin, and heme oxygenase in brains of BALB/c mice.	Iron	15-19	ferritin light polypeptide 1	Mus musculus	120-130
11925460-2	2002	Recent identification of proteins that are involved in iron absorption such as the uptake transporter-divalent metal transporter (DMT1), the basolateral transporter, IREG1, and the ferroxidase-hephaestin provide new opportunities to study this process.	Iron	55-59	RoBo-1	Rattus norvegicus	130-134
11925460-6	2002	The uptake of 1 micromol/L ferrous iron [Fe(II)]:ascorbate and its efflux also was associated with the expression of DMT1 under different levels of iron loading.	Iron	27-39	RoBo-1	Rattus norvegicus	117-121
11925460-6	2002	The uptake of 1 micromol/L ferrous iron [Fe(II)]:ascorbate and its efflux also was associated with the expression of DMT1 under different levels of iron loading.	Iron	35-39	RoBo-1	Rattus norvegicus	117-121
11925460-7	2002	The expression of DMT1 changed inversely with iron levels as did the uptake of Fe(II).	Iron	46-50	RoBo-1	Rattus norvegicus	18-22
11842003-6	2002	These results suggest that DMT1, Fpn1, and Heph are involved in the iron uptake process modulated by copper status.	Iron	68-72	hephaestin	Homo sapiens	43-47
11850263-6	2002	These genes exhibit similar expression patterns, and several are known to be regulated by AFT1, a DNA binding protein, which responds to iron levels in the cell.	Iron	137-141	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	90-94
11875007-1	2002	BACKGROUND &amp; AIMS: Hfe knockout mice, like patients with hereditary hemochromatosis, have augmented duodenal iron absorption and increased iron deposition in hepatic parenchymal cells.	Iron	113-117	homeostatic iron regulator	Mus musculus	23-26
11875007-1	2002	BACKGROUND &amp; AIMS: Hfe knockout mice, like patients with hereditary hemochromatosis, have augmented duodenal iron absorption and increased iron deposition in hepatic parenchymal cells.	Iron	143-147	homeostatic iron regulator	Mus musculus	23-26
11935358-9	2002	However, thorough analysis of the ELDOR decay curves and simulations suggests a distribution of intramolecular Mo...Fe distances, consistent with the proposal of multiple conformations in solution for the flexible loop that connects the Mo and heme domains of SO.	Iron	116-118	sulfite oxidase	Gallus gallus	260-262
12030366-4	2002	We found that, in the presence of iron, a natural substrate of GGT, glutathione induces lipid peroxidation in U937 cells.	Iron	34-38	inactive glutathione hydrolase 2	Homo sapiens	63-66
11829592-5	2002	Here we employ a dual-iron-isotope (56Fe/57Fe) approach to demonstrate the existence of a unique Fe site in the [4Fe-4S] cluster of PFL-AE by Mossbauer spectroscopy.	Iron	22-26	profilin 2	Homo sapiens	132-135
11829592-5	2002	Here we employ a dual-iron-isotope (56Fe/57Fe) approach to demonstrate the existence of a unique Fe site in the [4Fe-4S] cluster of PFL-AE by Mossbauer spectroscopy.	Iron	38-40	profilin 2	Homo sapiens	132-135
11839561-0	2002	Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis.	Iron	74-78	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	25-28
11839561-0	2002	Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis.	Iron	74-78	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	30-35
11839561-4	2002	By the use of fluorescent in situ hybridization in combination with imprint cytology at single-cell resolution, we found that the number of renal tubular cells with aneuploidy (1 or 3 signals) at the p16(INK4A) locus was significantly and specifically increased (1 week, 37.2 +/- 2.3%; 3 weeks, 37.8 +/- 1.3% vs control, 22.5 +/- 1.9%; mean +/- SE, N = 8; P &lt; 0.001 and P &lt; 0.0001, respectively) after repeated intraperitoneal administration of 5 to10 mg of iron/kg in the form of Fe-NTA for 3 weeks.	Iron	464-468	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	200-203
11839561-4	2002	By the use of fluorescent in situ hybridization in combination with imprint cytology at single-cell resolution, we found that the number of renal tubular cells with aneuploidy (1 or 3 signals) at the p16(INK4A) locus was significantly and specifically increased (1 week, 37.2 +/- 2.3%; 3 weeks, 37.8 +/- 1.3% vs control, 22.5 +/- 1.9%; mean +/- SE, N = 8; P &lt; 0.001 and P &lt; 0.0001, respectively) after repeated intraperitoneal administration of 5 to10 mg of iron/kg in the form of Fe-NTA for 3 weeks.	Iron	464-468	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	204-209
22896884-8	2002	However, the iron-binding environment in goat lactoferrin is somewhat different, in which 2 CO3(2-).	Iron	13-17	lactotransferrin	Capra hircus	46-57
12139399-0	2002	The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine.	Iron	37-41	hephaestin	Homo sapiens	62-72
12139399-0	2002	The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine.	Iron	116-120	hephaestin	Homo sapiens	62-72
12139399-3	2002	The basolateral transfer of iron requires two components: a copper-containing iron oxidase known as hephaestin and a membrane transport protein IREG1.	Iron	28-32	hephaestin	Homo sapiens	100-110
12401947-11	2002	The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards.	Iron	96-100	KRAS proto-oncogene, GTPase	Rattus norvegicus	48-51
12401947-11	2002	The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards.	Iron	240-244	KRAS proto-oncogene, GTPase	Rattus norvegicus	48-51
11734641-0	2001	A second iron-regulatory system in yeast independent of Aft1p.	Iron	9-13	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	56-61
11734641-1	2001	Iron homeostasis in the yeast Saccharomyces cerevisiae is regulated at the transcriptional level by Aft1p, which activates the expression of its target genes in response to low-iron conditions.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	100-105
11734641-1	2001	Iron homeostasis in the yeast Saccharomyces cerevisiae is regulated at the transcriptional level by Aft1p, which activates the expression of its target genes in response to low-iron conditions.	Iron	177-181	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	100-105
11734641-13	2001	Together, these data suggest that yeast has a second regulatory pathway for the iron regulon, with AFT1 and AFT2 playing partially redundant roles.	Iron	80-84	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	99-103
11703367-3	2001	We investigated the effects of oxidation reactions catalysed by copper or iron on the major beta-cell autoantigen glutamic acid decarboxylase (GAD).	Iron	74-78	glutamate decarboxylase 1	Homo sapiens	114-141
11703367-3	2001	We investigated the effects of oxidation reactions catalysed by copper or iron on the major beta-cell autoantigen glutamic acid decarboxylase (GAD).	Iron	74-78	glutamate decarboxylase 1	Homo sapiens	143-146
11709207-3	2001	Such increases in tissue iron content may be attributed to the stabilisation of IRP-2 by aluminium thereby promoting transferrin receptor synthesis while blocking ferritin synthesis.	Iron	25-29	iron responsive element binding protein 2	Rattus norvegicus	80-85
11695186-4	2001	We used a potent photoaffinity ligand, (trifluoromethyl)diazirinyl[3H]pyridaben, to localize the insecticide target to a single high-affinity site in the PSST subunit that couples electron transfer from iron-sulfur cluster N2 to ubiquinone.	Iron	203-207	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	154-158
11552799-1	2001	The rigid tris- and bis(catecholamide) ligands H(6)A, H(4)B and H(4)C form tetrahedral clusters of the type M(4)L(4) and M(4)L(6) through self-assembly reactions with tri- and tetravalent metal ions such as Ga(III), Fe(III), Ti(IV) and Sn(IV).	Iron	216-218	H4 clustered histone 4	Homo sapiens	47-69
11448968-10	2001	These results suggest that Aft2p and Aft1p have overlapping roles in the control of iron-regulated pathway(s) connected to oxidative stress resistance in yeast.	Iron	84-88	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	37-42
11559032-3	2001	The activity of TPH exposed to T-4,5-D cannot be restored by anaerobic reduction with dithiothreitol (DTT) and ferrous iron (Fe(2+)) indicating that the inactivation is irreversible.	Iron	111-123	tryptophan hydroxylase 1	Rattus norvegicus	16-19
11579132-5	2001	HSP32 represents heme oxygenase 1 (HO-1), a small stress protein with enzymatic activity involved in the oxidative degradation of heme which participates in iron metabolism.	Iron	157-161	heme oxygenase 1	Rattus norvegicus	0-5
11579132-5	2001	HSP32 represents heme oxygenase 1 (HO-1), a small stress protein with enzymatic activity involved in the oxidative degradation of heme which participates in iron metabolism.	Iron	157-161	heme oxygenase 1	Rattus norvegicus	17-33
11579132-5	2001	HSP32 represents heme oxygenase 1 (HO-1), a small stress protein with enzymatic activity involved in the oxidative degradation of heme which participates in iron metabolism.	Iron	157-161	heme oxygenase 1	Rattus norvegicus	35-39
11579132-6	2001	The presence of the iron chelators phenanthroline or deferoxamine (DFO), which previously has been shown to protect oligodendrocytes from oxidative stress-induced onset of apoptosis, caused a marked stimulation of HSP32 without affecting HSP70.	Iron	20-24	heme oxygenase 1	Rattus norvegicus	214-219
11514664-9	2001	In contrast, azide is bound to the oxidized heme iron in the methemoglobin crystals at an angle of 112 degrees, in a perfect orientation to accept a hydrogen bond from His63.	Iron	49-53	hemoglobin subunit gamma 2	Homo sapiens	61-74
11469807-1	2001	High-affinity iron uptake by yeast cells appears to require the presence of a complex formed on the plasma membrane by the multicopper oxidase Fet3 and the permease Ftr1 which work together to allow iron to enter safely inside the cell.	Iron	14-18	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	165-169
11469807-1	2001	High-affinity iron uptake by yeast cells appears to require the presence of a complex formed on the plasma membrane by the multicopper oxidase Fet3 and the permease Ftr1 which work together to allow iron to enter safely inside the cell.	Iron	199-203	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	165-169
11498468-1	2001	Heme oxygenase-1 (HO-1) catalyzes the regiospecific oxidative degradation of heme to biliverdin IXalpha, iron, and carbon monoxide.	Iron	105-109	heme oxygenase 1	Oryctolagus cuniculus	0-16
11498468-1	2001	Heme oxygenase-1 (HO-1) catalyzes the regiospecific oxidative degradation of heme to biliverdin IXalpha, iron, and carbon monoxide.	Iron	105-109	heme oxygenase 1	Oryctolagus cuniculus	18-22
11563810-4	2001	However, the products of the GGT reaction may themselves lead to increased free radical production, particularly in the presence of iron.	Iron	132-136	gamma-glutamyltransferase 1	Homo sapiens	29-32
11447267-2	2001	We report here a peculiar phenotype of Usf2(-/-) mice that progressively develop multivisceral iron overload; plasma iron overcomes transferrin binding capacity, and nontransferrin-bound iron accumulates in various tissues including pancreas and heart.	Iron	117-121	transferrin	Mus musculus	132-143
11447267-2	2001	We report here a peculiar phenotype of Usf2(-/-) mice that progressively develop multivisceral iron overload; plasma iron overcomes transferrin binding capacity, and nontransferrin-bound iron accumulates in various tissues including pancreas and heart.	Iron	117-121	transferrin	Mus musculus	132-143
11447267-6	2001	Accumulation of iron in the liver has been recently reported to up-regulate hepcidin expression, whereas our data clearly show that a complete defect in hepcidin expression is responsible for progressive tissue iron overload.	Iron	16-20	hepcidin antimicrobial peptide	Mus musculus	76-84
11447267-6	2001	Accumulation of iron in the liver has been recently reported to up-regulate hepcidin expression, whereas our data clearly show that a complete defect in hepcidin expression is responsible for progressive tissue iron overload.	Iron	211-215	hepcidin antimicrobial peptide	Mus musculus	153-161
11447267-7	2001	The striking similarity of the alterations in iron metabolism between HFE knockout mice, a murine model of hereditary hemochromatosis, and the Usf2(-/-) hepcidin-deficient mice suggests that hepcidin may function in the same regulatory pathway as HFE.	Iron	46-50	hepcidin antimicrobial peptide	Mus musculus	191-199
11447267-8	2001	We propose that hepcidin acts as a signaling molecule that is required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages.	Iron	123-127	hepcidin antimicrobial peptide	Mus musculus	16-24
11447267-8	2001	We propose that hepcidin acts as a signaling molecule that is required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages.	Iron	123-127	homeostatic iron regulator	Mus musculus	91-94
11447267-8	2001	We propose that hepcidin acts as a signaling molecule that is required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages.	Iron	143-147	hepcidin antimicrobial peptide	Mus musculus	16-24
11447267-8	2001	We propose that hepcidin acts as a signaling molecule that is required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages.	Iron	143-147	homeostatic iron regulator	Mus musculus	91-94
11297549-1	2001	The expression of several proteins with critical functions in iron metabolism is regulated post-transcriptionally by the binding of iron regulatory proteins, IRP1 and IRP2, to mRNA iron responsive elements (IREs).	Iron	62-66	iron responsive element binding protein 2	Rattus norvegicus	167-171
11297549-1	2001	The expression of several proteins with critical functions in iron metabolism is regulated post-transcriptionally by the binding of iron regulatory proteins, IRP1 and IRP2, to mRNA iron responsive elements (IREs).	Iron	132-136	iron responsive element binding protein 2	Rattus norvegicus	167-171
11297549-1	2001	The expression of several proteins with critical functions in iron metabolism is regulated post-transcriptionally by the binding of iron regulatory proteins, IRP1 and IRP2, to mRNA iron responsive elements (IREs).	Iron	132-136	iron responsive element binding protein 2	Rattus norvegicus	167-171
11297549-2	2001	In iron-deficient tissues and cultured cells, both IRP1 and IRP2 are activated for high affinity IRE binding.	Iron	3-7	iron responsive element binding protein 2	Rattus norvegicus	60-64
11278728-0	2001	J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins.	Iron	60-64	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	18-23
11278728-11	2001	Similar mitochondrial localization and similar mutant phenotypes suggest that Ssq1p and Jac1p are functional partners in iron homeostasis.	Iron	121-125	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	88-93
11336654-1	2001	Ferrochelatase (EC 4.99.1.1) is the terminal enzyme of the haem biosynthetic pathway and catalyses iron chelation into the protoporphyrin IX ring.	Iron	99-103	ferrochelatase	Mus musculus	0-14
11278521-6	2001	OLE1 expression was also increased in the presence of the iron chelator 1,10-phenanthroline.	Iron	58-62	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
11297741-2	2001	Both predicted proteins consist of 258 amino acid residues (77% identity) which show sequence similarity to di-iron-binding enzymes, such as Sur2p and Erg3p from yeast, involved in oxygen-dependent lipid modifications.	Iron	111-115	sphingosine hydroxylase	Saccharomyces cerevisiae S288C	141-146
11297741-2	2001	Both predicted proteins consist of 258 amino acid residues (77% identity) which show sequence similarity to di-iron-binding enzymes, such as Sur2p and Erg3p from yeast, involved in oxygen-dependent lipid modifications.	Iron	111-115	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	151-156
11112771-2	2001	Deletion of YFH1, the yeast frataxin homologue gene, elicits mitochondrial iron accumulation and alters cellular iron homeostasis.	Iron	75-79	ferroxidase	Saccharomyces cerevisiae S288C	12-16
11112771-2	2001	Deletion of YFH1, the yeast frataxin homologue gene, elicits mitochondrial iron accumulation and alters cellular iron homeostasis.	Iron	113-117	ferroxidase	Saccharomyces cerevisiae S288C	12-16
11112771-4	2001	Frataxin deficiency results in enhanced expression of some 70 genes including a set of genes, called the iron regulon, that are under the control of the iron-sensing transcription factor AFT1.	Iron	105-109	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	187-191
11112771-4	2001	Frataxin deficiency results in enhanced expression of some 70 genes including a set of genes, called the iron regulon, that are under the control of the iron-sensing transcription factor AFT1.	Iron	153-157	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	187-191
11112771-11	2001	Our data show that frataxin deficiency elicits iron mobilization from all iron sources in an AFT1-dependent manner.	Iron	47-51	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	93-97
11112771-11	2001	Our data show that frataxin deficiency elicits iron mobilization from all iron sources in an AFT1-dependent manner.	Iron	74-78	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	93-97
11226304-0	2001	Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis.	Iron	47-51	homeostatic iron regulator	Mus musculus	68-71
11226304-2	2001	Clinical studies demonstrate that the severity of iron loading is highly variable among individuals with identical HFE genotypes.	Iron	50-54	homeostatic iron regulator	Mus musculus	115-118
11349296-6	2001	This study indicates that oxidation state of the structural Fe in SWa greatly alters surface chemistry and has a large impact on clay-organic interactions.	Iron	60-62	intersectin 2	Homo sapiens	66-69
11327812-12	2001	Both S(EPR1) and S(EPR2) exhibit similar relaxation properties that are atypical for S = 1/2 signals originating from Fe-S clusters or radicals and indicate a coupled relaxation pathway.	Iron	118-122	baculoviral IAP repeat containing 5	Homo sapiens	7-11
11172342-0	2001	Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda.	Iron	72-74	homeostatic iron regulator	Mus musculus	16-19
11172342-3	2001	Mice homozygous for either the null mutation in the Hfe gene or the C282Y missense mutation rapidly accumulate hepatic parenchymal iron similar to patients with hemochromatosis.	Iron	131-135	homeostatic iron regulator	Mus musculus	52-55
11172342-8	2001	Iron in both wild-type and Hfe (+/-) mice was mostly in Kupffer cells.	Iron	0-4	homeostatic iron regulator	Mus musculus	27-30
11172342-9	2001	In contrast, Hfe (-/-) mice had considerable parenchymal iron deposition as well, in a pattern similar to that observed in wild-type mice treated with iron carbonyl.	Iron	57-61	homeostatic iron regulator	Mus musculus	13-16
11172342-9	2001	In contrast, Hfe (-/-) mice had considerable parenchymal iron deposition as well, in a pattern similar to that observed in wild-type mice treated with iron carbonyl.	Iron	151-155	homeostatic iron regulator	Mus musculus	13-16
11167127-4	2001	Upon deletion of the homologous gene (YFH1) in the yeast, there was an accumulation of iron (Fe) within the mitochondrion.	Iron	87-91	ferroxidase	Saccharomyces cerevisiae S288C	38-42
11204699-6	2001	These data suggest that uterine secretion of uteroferrin and secreted folate-binding protein are not influenced by plasma levels of iron and folate, respectively, and may provide an explanation for the equivocal effect of iron and folate treatment on reproductive performance in gilts.	Iron	222-226	acid phosphatase 5, tartrate resistant	Sus scrofa	45-56
11093950-1	2000	Recently, mutation of the DMT1 gene has been discovered to cause ineffective intestinal iron uptake and abnormal body iron metabolism in the anemic Belgrade rat and mk mouse.	Iron	88-92	RoBo-1	Rattus norvegicus	26-30
11093950-1	2000	Recently, mutation of the DMT1 gene has been discovered to cause ineffective intestinal iron uptake and abnormal body iron metabolism in the anemic Belgrade rat and mk mouse.	Iron	118-122	RoBo-1	Rattus norvegicus	26-30
11106561-0	2000	Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1.	Iron	0-4	recombination activating 1	Mus musculus	84-88
11106561-8	2000	Thus, the development of iron-mediated cellular damage is substantially enhanced when a Rag1 mutation, which causes a lack of mature lymphocytes, is introduced into ss2m(-/-) mice.	Iron	25-29	recombination activating 1	Mus musculus	88-92
11106561-9	2000	Mice deficient in ss2m and Rag1 thus offer a new experimental model of iron-related cardiomyopathy.	Iron	71-75	recombination activating 1	Mus musculus	27-31
11083823-3	2000	can sequester iron from this protein, dependent upon two iron-repressible, transferrin-binding proteins (TbpA and TbpB).	Iron	14-18	transthyretin	Homo sapiens	105-109
11083823-3	2000	can sequester iron from this protein, dependent upon two iron-repressible, transferrin-binding proteins (TbpA and TbpB).	Iron	57-61	transthyretin	Homo sapiens	105-109
11083823-9	2000	These data implicate putative loops 4 and 5 as critical determinants for receptor function and transferrin-iron uptake by gonococcal TbpA.	Iron	107-111	transthyretin	Homo sapiens	133-137
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	101-105	transferrin	Mus musculus	123-134
11054110-1	2000	The natural resistance associated macrophage protein 2 (Nramp2) is a transporter that is involved in iron (Fe) uptake from transferrin (Tf) and low molecular mass Fe complexes.	Iron	107-109	transferrin	Mus musculus	123-134
11069629-8	2000	Terminal deoxynucleotidyl transferase-mediated desoxyuridinetriphosphate nick end labeling assay, flow cytometry with annexin-V-fluorescein and morphologic analysis indicated that iron chelation also induced a time- and concentration-dependent apoptosis.	Iron	180-184	DNA nucleotidylexotransferase	Homo sapiens	0-37
11035780-5	2000	The Arabidopsis root membrane protein IRT1 is likely to be responsible for uptake of iron from the soil.	Iron	85-89	iron-regulated transporter 1	Arabidopsis thaliana	38-42
11035780-8	2000	Two other mutations, replacing the aspartic acid residues at either positions 100 or 136 with alanine, also increase IRT1 metal selectivity by eliminating transport of both iron and manganese.	Iron	173-177	iron-regulated transporter 1	Arabidopsis thaliana	117-121
10889193-1	2000	Intracellular iron homeostasis is regulated, in part, by interactions between iron-regulatory proteins (IRP1 and IRP2) and iron-responsive elements (IREs) in ferritin and transferrin receptor mRNAs.	Iron	14-18	iron responsive element binding protein 2	Rattus norvegicus	113-117
11024540-1	2000	The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin.	Iron	96-100	heme oxygenase 1	Rattus norvegicus	29-33
11051552-4	2000	The PmrB protein bound iron via its periplasmic domain which harbors two copies of the sequence ExxE, a motif present in the Saccharomyces FTR1 iron transporter and in mammalian ferritin light chain.	Iron	23-27	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	139-143
10945243-0	2000	Examination of the mechanism of action of nitrogen monoxide on iron uptake from transferrin.	Iron	63-67	transferrin	Mus musculus	80-91
10945243-2	2000	Previously we have shown that NO produced by NO-generating agents decreased cellular Fe uptake from transferrin (Tf).	Iron	85-87	transferrin	Mus musculus	100-111
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	14-18	RoBo-1	Rattus norvegicus	216-220
10859223-1	2000	Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells.	Iron	14-18	RoBo-1	Rattus norvegicus	232-236
10859223-3	2000	We showed that DMT1 in our colony of b/b rats contains the G185R mutation, which in enterocytes results in reduced cellular iron content and increased DMT1 gene expression similar to levels in iron deficiency of normal rats.	Iron	124-128	RoBo-1	Rattus norvegicus	15-19
10859223-3	2000	We showed that DMT1 in our colony of b/b rats contains the G185R mutation, which in enterocytes results in reduced cellular iron content and increased DMT1 gene expression similar to levels in iron deficiency of normal rats.	Iron	193-197	RoBo-1	Rattus norvegicus	15-19
10781110-6	2000	Furthermore, AtNramp3 and AtNramp4 complement an iron uptake mutant in yeast.	Iron	49-53	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	13-21
10781110-6	2000	Furthermore, AtNramp3 and AtNramp4 complement an iron uptake mutant in yeast.	Iron	49-53	natural resistance associated macrophage protein 4	Arabidopsis thaliana	26-34
10781110-9	2000	Interestingly, AtNramp3 and AtNramp4 are induced by iron starvation.	Iron	52-56	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	15-23
10781110-9	2000	Interestingly, AtNramp3 and AtNramp4 are induced by iron starvation.	Iron	52-56	natural resistance associated macrophage protein 4	Arabidopsis thaliana	28-36
10781110-11	2000	Furthermore, overexpression of AtNramp3 results in cadmium hypersensitivity of Arabidopsis root growth and increased accumulation of Fe, on Cd(2+) treatment.	Iron	133-135	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	31-39
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	132-136	mitochondrial intermediate peptidase	Homo sapiens	34-70
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	mitochondrial intermediate peptidase	Homo sapiens	34-70
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	mitochondrial intermediate peptidase	Homo sapiens	34-70
10783257-1	2000	We showed recently that the yeast mitochondrial intermediate peptidase (YMIP polypeptide; gene symbol, OCT1) promotes mitochondrial iron uptake by catalyzing the maturation of iron-utilizing proteins and exacerbates the mitochondrial iron accumulation that results from loss of yeast frataxin, a mitochondrial protein required for mitochondrial iron efflux.	Iron	176-180	mitochondrial intermediate peptidase	Homo sapiens	34-70
10744769-2	2000	In the yeast Saccharomyces cerevisiae, uptake of iron is largely regulated by the transcription factor Aft1.	Iron	49-53	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	103-107
10786005-4	2000	The consumable Fe electrodes generate ferrous ions to cause the reduction of Cr6+ to Cr3+.	Iron	15-17	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	77-80
10727219-3	2000	We found that when ascorbate was added to the oxidized form of diethyl pyrocarbonate-treated cytochrome b(561), less than half of the heme iron was reduced but with a very slow rate.	Iron	139-143	cytochrome b	Bos taurus	93-105
10727233-0	2000	Interaction between 6-hydroxydopamine and transferrin: "Let my iron go".	Iron	63-67	transferrin	Mus musculus	42-53
10727233-3	2000	We tested the hypothesis that the toxicity of 6-OHDA is caused by its interaction with serum ferric transferrin (Fe-TF) resulting in release of iron.	Iron	144-148	transferrin	Mus musculus	100-111
10692416-0	2000	Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2.	Iron	65-69	iron responsive element binding protein 2	Mus musculus	133-158
10692416-3	2000	Moreover, NO(*), a redox species of nitric oxide that interacts primarily with iron, can activate IRP-1 RNA binding activity resulting in an increase in TfR mRNA levels.	Iron	79-83	aconitase 1	Mus musculus	98-103
10692416-10	2000	These results suggest that NO(+)-mediated degradation of IRP-2 plays a major role in iron metabolism during inflammation.	Iron	85-89	iron responsive element binding protein 2	Mus musculus	57-62
10706130-3	2000	In addition, Fes has been shown to associate with and phosphorylate Bcr on NH2-terminal sequences retained within Bcr-Abl.	Iron	13-16	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	114-121
10719247-4	2000	Here, we argue that (i) the heavily glycated proteins known to accumulate in people with diabetes gain an increased affinity for transition metals such as iron and copper, (ii) as a result, proteins such as elastin and collagen within the arterial wall-which are known to be particularly heavily glycosylated in diabetes-may accumulate bound metal, especially copper, (iii) the bound metal causes the catalytic destruction of endothelium derived relaxing factor (nitric oxide or a derivative thereof), thereby engendering a state of chronic vasoconstriction.	Iron	155-159	elastin	Homo sapiens	207-214
10644324-5	2000	RESULTS: Duodenal DMT1 mRNA was low in crypts and increased at the crypt-villus junction in iron deficient and control rats; it fell in the iron loaded state.	Iron	92-96	RoBo-1	Rattus norvegicus	18-22
10644324-9	2000	DMT1 protein staining was observed on hepatocyte plasma membranes, with highest values in the iron loaded state, lower values in control animals, and none after iron depletion.	Iron	94-98	RoBo-1	Rattus norvegicus	0-4
10644324-9	2000	DMT1 protein staining was observed on hepatocyte plasma membranes, with highest values in the iron loaded state, lower values in control animals, and none after iron depletion.	Iron	161-165	RoBo-1	Rattus norvegicus	0-4
10644324-10	2000	CONCLUSIONS: Results are consistent with a role for DMT1 in the transmembrane transport of non-transferrin bound iron from the intestinal lumen and from the portal blood.	Iron	113-117	RoBo-1	Rattus norvegicus	52-56
10810445-10	2000	As with iron and ferritin contents, total iron regulatory protein (IRP-1) binding capacity for mRNA iron responsive element (IRE) and actual IRE/IRP binding in the liver were significantly greater in SWR than C57BL/6J mice.	Iron	8-12	aconitase 1	Mus musculus	67-72
10810445-10	2000	As with iron and ferritin contents, total iron regulatory protein (IRP-1) binding capacity for mRNA iron responsive element (IRE) and actual IRE/IRP binding in the liver were significantly greater in SWR than C57BL/6J mice.	Iron	42-46	aconitase 1	Mus musculus	67-72
10865941-11	2000	The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf.	Iron	32-34	BEN domain containing 3	Mus musculus	50-55
10865941-11	2000	The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf.	Iron	32-34	transferrin	Mus musculus	128-130
10865941-11	2000	The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf.	Iron	32-34	transferrin	Mus musculus	128-130
10865941-11	2000	The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf.	Iron	120-122	transferrin	Mus musculus	25-27
10865941-11	2000	The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf.	Iron	120-122	BEN domain containing 3	Mus musculus	50-55
10865941-11	2000	The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf.	Iron	120-122	transferrin	Mus musculus	128-130
10865941-11	2000	The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf.	Iron	120-122	transferrin	Mus musculus	128-130
10613864-6	2000	While MR1-CYMA retained menaquinone levels comparable to those of MR-1, it lost the ability to reduce iron(III), manganese(IV), and nitrate and to grow by using fumarate as an electron acceptor.	Iron	102-106	cytochrome c	Shewanella oneidensis MR-1	10-14
10561526-2	1999	These mice provide a unique opportunity to examine the role of Tf in Fe and Mn transport in the brain.	Iron	69-71	transferrin	Mus musculus	63-65
10561526-12	1999	We interpret these data to mean that Tf is necessary for the transport of Fe but not Mn across the blood-brain barrier, and that there is a Tf-independent uptake mechanism for iron in the choroid plexus.	Iron	74-76	transferrin	Mus musculus	37-39
10561526-12	1999	We interpret these data to mean that Tf is necessary for the transport of Fe but not Mn across the blood-brain barrier, and that there is a Tf-independent uptake mechanism for iron in the choroid plexus.	Iron	176-180	transferrin	Mus musculus	140-142
10561526-13	1999	Additionally, these data suggest that endogenous synthesis of Tf is necessary for Fe transport from the choroid plexus.	Iron	82-84	transferrin	Mus musculus	62-64
10561552-1	1999	Ferrochelatase (protoheme ferrolyase, EC 4.99.1.1) catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.	Iron	130-142	ferrochelatase	Homo sapiens	0-14
10551871-4	1999	This mutant exhibited constitutive up-regulation of the genes of the cellular iron uptake system, mediated through effects on the Aft1p iron-regulatory protein.	Iron	78-82	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	130-135
10551872-1	1999	Cellular iron storage and uptake are coordinately regulated post-transcriptionally by cytoplasmic factors, iron-regulatory proteins 1 and 2 (IRP-1 and IRP-2).	Iron	9-13	aconitase 1	Mus musculus	107-139
10551872-1	1999	Cellular iron storage and uptake are coordinately regulated post-transcriptionally by cytoplasmic factors, iron-regulatory proteins 1 and 2 (IRP-1 and IRP-2).	Iron	9-13	aconitase 1	Mus musculus	141-146
10551872-1	1999	Cellular iron storage and uptake are coordinately regulated post-transcriptionally by cytoplasmic factors, iron-regulatory proteins 1 and 2 (IRP-1 and IRP-2).	Iron	9-13	iron responsive element binding protein 2	Mus musculus	151-156
10531234-5	1999	In vitro growth studies, comparing all three mutants, demonstrated that the tbpA mutant and the tbpAB mutant were severely limited in their ability to grow with human holotransferrin as the sole source of iron.	Iron	205-209	transthyretin	Homo sapiens	76-80
10531234-9	1999	These data suggest that the M. catarrhalis TbpA is necessary for the acquisition of iron from transferrin.	Iron	84-88	transthyretin	Homo sapiens	43-47
10577506-8	1999	Analysis of the endogenous iron sensors, iron regulatory protein 1 and 2, reveals a greater flux of iron in Nramp1-expressing cells and in its exclusion from the cytoplasm.	Iron	27-31	aconitase 1	Mus musculus	41-72
10525116-11	1999	In the absence of PBN pretreatment, there was an intense immunostaining for HO-1 in the medullary rays, which corresponded with iron and lipid peroxidation staining of the region; these observations were not made with PBN-pretreated kidneys.	Iron	128-132	heme oxygenase 1	Rattus norvegicus	76-80
10529220-8	1999	268, 6995-7010] that a mutation at position 29 (B10, helix notation), e.g. , Leu --&gt; Phe, can inhibit the autoxidation of the heme iron of myoglobin.	Iron	134-138	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	48-51
10498610-2	1999	Stimulation of macrophages with interferon-gamma (IFN-gamma) and/or lipopolysaccharide (LPS) decreased Fe uptake from transferrin (Tf), and there was a concomitant downregulation of TfR expression.	Iron	103-105	transferrin	Mus musculus	118-129
10498610-2	1999	Stimulation of macrophages with interferon-gamma (IFN-gamma) and/or lipopolysaccharide (LPS) decreased Fe uptake from transferrin (Tf), and there was a concomitant downregulation of TfR expression.	Iron	103-105	transferrin	Mus musculus	131-133
10428860-2	1999	Yeast mutants lacking the yeast frataxin homologue (Yfh1p) show iron accumulation in mitochondria and increased sensitivity to oxidative stress, suggesting that frataxin plays a critical role in mitochondrial iron homeostasis and free radical toxicity.	Iron	64-68	ferroxidase	Saccharomyces cerevisiae S288C	52-57
10428860-2	1999	Yeast mutants lacking the yeast frataxin homologue (Yfh1p) show iron accumulation in mitochondria and increased sensitivity to oxidative stress, suggesting that frataxin plays a critical role in mitochondrial iron homeostasis and free radical toxicity.	Iron	64-68	frataxin	Mus musculus	32-40
10428860-2	1999	Yeast mutants lacking the yeast frataxin homologue (Yfh1p) show iron accumulation in mitochondria and increased sensitivity to oxidative stress, suggesting that frataxin plays a critical role in mitochondrial iron homeostasis and free radical toxicity.	Iron	209-213	ferroxidase	Saccharomyces cerevisiae S288C	52-57
10428860-2	1999	Yeast mutants lacking the yeast frataxin homologue (Yfh1p) show iron accumulation in mitochondria and increased sensitivity to oxidative stress, suggesting that frataxin plays a critical role in mitochondrial iron homeostasis and free radical toxicity.	Iron	209-213	frataxin	Mus musculus	32-40
10555573-2	1999	Large anions such as EDTA do not inhibit IET as dramatically as do small anions such as SO4(2-) and Cl-, which suggests that specific anion binding at the sterically constrained Mo active site is necessary for IET inhibition to occur.IET may require that SO adopt a conformation in which the Mo and Fe centers are held in close proximity by electrostatic interactions between the predominantly positively charged Mo active site, and the negatively charged heme edge.	Iron	299-301	sulfite oxidase	Gallus gallus	88-90
10409623-12	1999	Taken together, TfR2-alpha may be a second transferrin receptor that can mediate cellular iron transport.	Iron	90-94	transferrin receptor protein 2	Cricetulus griseus	16-20
10391920-0	1999	In vitro biosynthesis of iron-molybdenum cofactor and maturation of the nif-encoded apodinitrogenase.	Iron	25-29	S100 calcium binding protein A9	Homo sapiens	72-75
10085238-1	1999	Neisseria meningitidis, grown in iron-limited conditions, produces two transferrin-binding proteins (TbpA and TbpB) that independently and specifically bind human serum transferrin (hTF) but not bovine serum transferrin (bTF).	Iron	33-37	transthyretin	Homo sapiens	101-105
10192390-1	1999	Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and attenuates its reactivity.	Iron	7-11	transferrin	Mus musculus	32-43
10192390-1	1999	Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and attenuates its reactivity.	Iron	7-11	transferrin	Mus musculus	45-48
10192390-5	1999	Although the Trf cycle is assumed to be the general mechanism for cellular iron uptake, this has not been validated experimentally.	Iron	75-79	transferrin	Mus musculus	13-16
10192390-7	1999	They have severe anaemia, indicating that the Trf cycle is essential for iron uptake by erythroid cells.	Iron	73-77	transferrin	Mus musculus	46-49
10066817-13	1999	Recruitment of these broadly active transcriptional adaptor proteins for ferritin H synthesis may represent an important mechanism by which changes in iron metabolism are coordinated with other cellular responses mediated by p300/CBP.	Iron	151-155	CREB binding protein	Mus musculus	230-233
10091654-5	1999	In this work, conformational changes in CRP induced by cAMP and cGMP binding were mapped and quantitatively analyzed by protein footprinting using iron complexed to diethylenetriaminepentaacetic acid ([Fe-DTPA]2-), iron complexed to ethylenediaminediacetic acid ([Fe-EDDA]), iron complexed to desferrioxamine mesylate ([Fe-HDFO]+), and copper complexed to o-phenanthroline ([(OP)2Cu]+) as proteases.	Iron	215-219	catabolite gene activator protein	Escherichia coli	40-43
10091654-5	1999	In this work, conformational changes in CRP induced by cAMP and cGMP binding were mapped and quantitatively analyzed by protein footprinting using iron complexed to diethylenetriaminepentaacetic acid ([Fe-DTPA]2-), iron complexed to ethylenediaminediacetic acid ([Fe-EDDA]), iron complexed to desferrioxamine mesylate ([Fe-HDFO]+), and copper complexed to o-phenanthroline ([(OP)2Cu]+) as proteases.	Iron	215-219	catabolite gene activator protein	Escherichia coli	40-43
9988680-3	1999	Yeast strains with a deletion in the frataxin homologue YFH1 accumulate excess iron in mitochondria and demonstrate mitochondrial damage.	Iron	79-83	ferroxidase	Saccharomyces cerevisiae S288C	56-60
9988680-5	1999	Reintroduction of YFH1 results in the rapid export of accumulated mitochondrial iron into the cytosol as free, non-heme bound iron, demonstrating that mitochondrial iron in the yeast FA model can be made bioavailable.	Iron	80-84	ferroxidase	Saccharomyces cerevisiae S288C	18-22
9988680-5	1999	Reintroduction of YFH1 results in the rapid export of accumulated mitochondrial iron into the cytosol as free, non-heme bound iron, demonstrating that mitochondrial iron in the yeast FA model can be made bioavailable.	Iron	126-130	ferroxidase	Saccharomyces cerevisiae S288C	18-22
9988680-5	1999	Reintroduction of YFH1 results in the rapid export of accumulated mitochondrial iron into the cytosol as free, non-heme bound iron, demonstrating that mitochondrial iron in the yeast FA model can be made bioavailable.	Iron	126-130	ferroxidase	Saccharomyces cerevisiae S288C	18-22
9988680-6	1999	These results demonstrate a mitochondrial iron cycle in which Yfh1p regulates mitochondrial iron efflux.	Iron	42-46	ferroxidase	Saccharomyces cerevisiae S288C	62-67
9988680-6	1999	These results demonstrate a mitochondrial iron cycle in which Yfh1p regulates mitochondrial iron efflux.	Iron	92-96	ferroxidase	Saccharomyces cerevisiae S288C	62-67
9920755-6	1999	It is, therefore, a reasonable inference that ligand binding at the heme iron atom is intimately connected with enzyme activation, a hypothesis that would have been difficult to maintain if the earlier report, that YC-1 has no effect on CO binding, were correct.	Iron	73-77	RNA binding motif single stranded interacting protein 1	Homo sapiens	215-219
9989256-1	1999	Protoporphyria is a disease characterized by a deficiency in ferrochelatase, the terminal enzyme in the heme biosynthetic pathway, which catalyzes the chelation of iron and protoporphyrin to form heme.	Iron	164-168	ferrochelatase	Homo sapiens	61-75
10736194-6	1999	This was further evidenced by extract-mediated protection (15 days prior feeding following a single necrogenic dose of CCl(4)) of the generation of DNA chain-break and Fe-sugar-base damage assays.	Iron	168-170	chemokine (C-C motif) ligand 4	Mus musculus	119-125
11498837-13	1999	The level of intracellular iron in non-induced and induced MEL cells had less effects on the expression of ferrochelatase mRNA.	Iron	27-31	ferrochelatase	Homo sapiens	107-121
9837819-4	1998	To determine the effect of Wilson disease missense mutations on ATP7B function, we have developed a yeast complementation assay based on the ability of ATP7B to complement the high-affinity iron-uptake deficiency of the yeast mutant ccc2.	Iron	190-194	ATPase copper transporting beta	Homo sapiens	152-157
9951704-5	1998	Using this assay, Scatchard analysis was performed on the data for the specific binding of iron-loaded transferrin to its receptors on mouse fibroblasts and yielded Kd values similar to those obtained with other published methods.	Iron	91-95	transferrin	Mus musculus	103-114
9808632-4	1998	Functional cloning studies in Xenopus oocytes have characterized DCT1 (Nramp2) as an iron-regulated proton-coupled divalent cation transporter.	Iron	85-89	solute carrier family 11 member 2 L homeolog	Xenopus laevis	65-69
9808632-4	1998	Functional cloning studies in Xenopus oocytes have characterized DCT1 (Nramp2) as an iron-regulated proton-coupled divalent cation transporter.	Iron	85-89	solute carrier family 11 member 2 L homeolog	Xenopus laevis	71-77
9770278-2	1998	The SA-tbp, detected by immunoblot assay, was iron-repressible, reacted with the convalescent sera, and cross-reacted with McAb-HTR.	Iron	46-50	TATA-box binding protein	Homo sapiens	7-10
9740232-2	1998	Ferrochelatase catalyzes the chelation of ferrous iron into protoporphyrin IX to form heme.	Iron	42-54	ferrochelatase	Homo sapiens	0-14
9712864-1	1998	High affinity iron transport in yeast is mediated by two proteins, Fet3p and Ftr1p.	Iron	14-18	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	77-82
9712864-2	1998	The multicopper oxidase Fet3p is thought to convert extracellular ferrous iron to ferric iron, which then crosses the plasma membrane through the permease Ftr1p.	Iron	66-78	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	155-160
9712864-3	1998	Fet3p is capable of oxidizing other substrates, such as p-phenylenediamine, and there is still a question of whether it is the ferroxidase activity that is essential for iron transport.	Iron	170-174	ferroxidase	Saccharomyces cerevisiae S288C	127-138
9712864-8	1998	These observations indicate that the ferroxidase activity of Fet3p is intrinsically required for high affinity iron transport.	Iron	111-115	ferroxidase	Saccharomyces cerevisiae S288C	37-48
10327419-4	1998	Both Fe and Al dosing elevated glutamine synthetase activity in the cortex.	Iron	5-7	glutamate-ammonia ligase	Rattus norvegicus	31-51
9657286-13	1998	In the kidney of Vit A + Ni treated mice, the increase of Cu, Fe, and Zn but not Ca, was reduced and not significantly different from control and Vit A-treated mice.	Iron	62-64	vitrin	Mus musculus	17-20
9657286-14	1998	Pretreatment with Vit A reduced the increased Fe, Cu, Zn and Ca concentration in the lung caused by Ni injection.	Iron	46-48	vitrin	Mus musculus	18-21
9646941-0	1998	Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide.	Iron	126-130	RNA binding motif single stranded interacting protein 1	Homo sapiens	55-59
9535853-7	1998	This is followed by redox equilibration of CuB with Fea/CuA or Fea3 (in which Fea and Fea3 are the iron centers of cytochromes a and a3, respectively).	Iron	99-103	FEA	Homo sapiens	52-55
9614701-3	1998	The supply of either whey proteins or beta-lactoglobulin resulted in an increase in liver GSH and prevented iron-mediated lipoprotein peroxidation.	Iron	108-112	beta-lactoglobulin	Bos taurus	38-56
9521697-3	1998	To better understand how L-Arg and H4B affect heme iron function in iNOSox, we utilized stopped-flow spectroscopy to study heme reactivity with CO and NO and the properties of the resulting CO and NO complexes.	Iron	51-55	H4 clustered histone 4	Homo sapiens	35-38
9521697-5	1998	Ferric iNOSox without L-Arg or H4B was dimeric and contained low-spin heme iron, while in H4B- or L-Arg-saturated iNOSox, the heme iron was partially or almost completely high-spin, respectively.	Iron	131-135	H4 clustered histone 4	Homo sapiens	90-93
9521697-6	1998	In the presence of L-Arg or H4B, the rate of CO binding to ferrous iNOSox was slowed considerably, indicating that these molecules restrict CO access to the heme iron.	Iron	162-166	H4 clustered histone 4	Homo sapiens	28-31
9521697-11	1998	Thus, H4B and L-Arg both promote a conformational change in the distal heme pocket of iNOSox that can greatly reduce ligand access to the heme iron.	Iron	143-147	H4 clustered histone 4	Homo sapiens	6-9
9482759-3	1998	Rats were fed a diet containing 2 or 34 mg iron/kg diet for 1-28 d. Liver IRP activity increased rapidly in rats fed the iron-deficient diet with IRP1 stimulated by d 1 and IRP2 by d 2.	Iron	43-47	iron responsive element binding protein 2	Rattus norvegicus	173-177
9482759-3	1998	Rats were fed a diet containing 2 or 34 mg iron/kg diet for 1-28 d. Liver IRP activity increased rapidly in rats fed the iron-deficient diet with IRP1 stimulated by d 1 and IRP2 by d 2.	Iron	121-125	iron responsive element binding protein 2	Rattus norvegicus	173-177
9514199-0	1998	Evidence for non-transferrin-mediated uptake and release of iron and manganese in glial cell cultures from hypotransferrinemic mice.	Iron	60-64	transferrin	Mus musculus	17-28
9514199-1	1998	Transferrin (Tf) is accepted as the iron mobilization protein, but its role in transport of other metals is controversial.	Iron	36-40	transferrin	Mus musculus	0-11
9514199-1	1998	Transferrin (Tf) is accepted as the iron mobilization protein, but its role in transport of other metals is controversial.	Iron	36-40	transferrin	Mus musculus	13-15
9506827-3	1998	Photofrin significantly increased spleen cell expression of the receptor (CD71) for the iron transport protein transferrin by 72 h post-injection but did not affect levels of a receptor (CD25) for the T-cell growth factor interleukin-2 (IL-2) or spleen cell responsiveness to rIL-2.	Iron	88-92	transferrin	Mus musculus	111-122
9398141-10	1997	Month-to-month changes in CHr correlated weakly with changes in serum iron and percent transferrin saturation, but not at all with changes in serum ferritin.	Iron	70-74	chromate resistance; sulfate transport	Homo sapiens	26-29
9398141-13	1997	After intravenous iron, CHr rose within 48 hours, peaked at 96 hours, and then fell toward baseline.	Iron	18-22	chromate resistance; sulfate transport	Homo sapiens	24-27
9398141-14	1997	Patients who were iron deficient by standard measures (serum ferritin &lt; 100 ng/mL or transferrin saturation less than 20%) had a greater and a sustained CHr response to intravenous iron dextran.	Iron	18-22	chromate resistance; sulfate transport	Homo sapiens	156-159
9398141-16	1997	Eighty-two percent of individuals who were iron deficient at baseline responded to intravenous iron with an increase in CHr of greater than 2 pg.	Iron	43-47	chromate resistance; sulfate transport	Homo sapiens	120-123
9398141-16	1997	Eighty-two percent of individuals who were iron deficient at baseline responded to intravenous iron with an increase in CHr of greater than 2 pg.	Iron	95-99	chromate resistance; sulfate transport	Homo sapiens	120-123
9398141-18	1997	We conclude that CHr may be a more sensitive marker of functional iron deficiency in rHuEPO-treated hemodialysis patients than percent transferrin saturation and ferritin, particularly in those with "normal" conventional iron parameters.	Iron	66-70	chromate resistance; sulfate transport	Homo sapiens	17-20
9368374-6	1997	The degree of NCP1 expression also affected the amount of iron and copper accumulated by the cells during growth.	Iron	58-62	NADPH--hemoprotein reductase	Saccharomyces cerevisiae S288C	14-18
9347801-1	1997	Human erythropoietic protoporphyria is an inherited disorder of the heme metabolic pathway caused by defects in the gene for ferrochelatase, the terminal enzyme of the pathway that catalyzes chelation of ferrous iron into protoporphyrin IX to form heme.	Iron	204-216	ferrochelatase	Homo sapiens	125-139
9344851-6	1997	The AA activation of mGPDH was likewise completely inhibited by iron specific chelators, bathophenanthrolinedisulfonic acid, desferrioxamine, and 1,10-phenanthroline, but the activation could not be restored by the addition of excess Ca2+.	Iron	64-68	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	21-26
9326946-9	1997	Moreover, disruption of the YFH1 gene resulted in multiple Fe-S-dependent enzyme deficiencies in yeast.	Iron	59-61	ferroxidase	Saccharomyces cerevisiae S288C	28-32
18966900-4	1997	The experimental results for such analytes as Pb, Mn, Cd, Cu and Fe indicate that the procedure can eliminate fundamentally the interferences caused by alkali and alkaline earth metal elements and the application of it to the determination of iron in industrial silicon and tap water samples is successful.	Iron	65-67	nuclear RNA export factor 1	Homo sapiens	274-277
18966900-4	1997	The experimental results for such analytes as Pb, Mn, Cd, Cu and Fe indicate that the procedure can eliminate fundamentally the interferences caused by alkali and alkaline earth metal elements and the application of it to the determination of iron in industrial silicon and tap water samples is successful.	Iron	243-247	nuclear RNA export factor 1	Homo sapiens	274-277
9252675-0	1997	Non-transferrin-bound iron and tumor cells.	Iron	22-26	transferrin	Mus musculus	4-15
9252675-5	1997	In the pathological evolution of iron overload to a neoplasia, the probable involvement of an iron exchange between iron complexes from non-transferrin-bound iron of plasma and ATP is discussed.	Iron	33-37	transferrin	Mus musculus	140-151
9252675-5	1997	In the pathological evolution of iron overload to a neoplasia, the probable involvement of an iron exchange between iron complexes from non-transferrin-bound iron of plasma and ATP is discussed.	Iron	94-98	transferrin	Mus musculus	140-151
9211366-3	1997	The purpose of this study was to evaluate the CHr for the assessment of iron status in hemodialysis patients.	Iron	72-76	chromate resistance; sulfate transport	Homo sapiens	46-49
9180083-0	1997	Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin.	Iron	28-32	ferroxidase	Saccharomyces cerevisiae S288C	49-54
9180083-3	1997	The yeast gene (yeast frataxin homolog, YFH1) encodes a mitochondrial protein involved in iron homeostasis and respiratory function.	Iron	90-94	ferroxidase	Saccharomyces cerevisiae S288C	40-44
9180083-5	1997	Characterizing the mechanism by which YFH1 regulates iron homeostasis in yeast may help to define the pathologic process leading to cell damage in Friedreich"s ataxia.	Iron	53-57	ferroxidase	Saccharomyces cerevisiae S288C	38-42
9182554-4	1997	The maize AO polypeptide contains consensus sequences for iron-sulfur centers and a putative molybdopterin cofactor-binding domain.	Iron	58-62	indole-3-acetaldehyde oxidase	Zea mays	10-12
9200812-0	1997	The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae.	Iron	91-95	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	4-8
9200812-5	1997	Aft1 protein is required for maintaining detectable non-induced level of FET3 expression and for induction of FRE2 in iron starvation conditions.	Iron	118-122	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
9200812-8	1997	The alterations in the basal levels of expression of the high-affinity iron uptake genes may explain why the AFT1 mutant is unable to grow on respirable carbon sources.	Iron	71-75	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	109-113
9200812-10	1997	Aft1 is a transcriptional activator that would be part of the different transcriptional complexes interacting with the promoter of the high-affinity iron uptake genes.	Iron	149-153	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
9200812-11	1997	Aft1 displays phosphorylation modifications depending on the growth stage of the cells, and it might link induction of genes for iron uptake to other metabolically dominant requirement for cell growth.	Iron	129-133	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
9385081-15	1997	In its anabolic role, as noted above, heme oxygenase produces bile pigments, carbon monoxide, and iron, all of which are biologically active: bile pigments function as antioxidants; the carbon monoxide generated by HO activity has been correlated with the generation of cGMP; and iron regulates expression of various genes, including that of HO-1 itself, as well as transferrin receptors, ferritin, and NO synthase.	Iron	98-102	heme oxygenase 1	Rattus norvegicus	342-346
9385081-15	1997	In its anabolic role, as noted above, heme oxygenase produces bile pigments, carbon monoxide, and iron, all of which are biologically active: bile pigments function as antioxidants; the carbon monoxide generated by HO activity has been correlated with the generation of cGMP; and iron regulates expression of various genes, including that of HO-1 itself, as well as transferrin receptors, ferritin, and NO synthase.	Iron	280-284	heme oxygenase 1	Rattus norvegicus	342-346
9002972-4	1997	We show that, in human (K562) and murine erythroleukemic cells (MEL), Epo enhances the binding affinity of iron-regulatory protein (IRP)-1, the central regulator of cellular iron metabolism, to specific RNA stem-loop structures, known as iron-responsive elements (IREs).	Iron	174-178	aconitase 1	Mus musculus	107-138
9119254-2	1997	Recent studies have shown however that in the presence of chelated iron prooxidant species can be originated during GGT-mediated metabolism of GSH, and that a process of lipid peroxidation can be started eventually in suitable lipid substrates.	Iron	67-71	inactive glutathione hydrolase 2	Homo sapiens	116-119
9119254-6	1997	GGT-stimulation of lipid peroxidation was dependent both on the concentration of GSH and of ADP-chelated iron.	Iron	105-109	inactive glutathione hydrolase 2	Homo sapiens	0-3
9116643-4	1996	Binding was inhibited by bovine lactoferrin, lactose, rhamnose, galactose, and two iron-containing proteins, ferritin and haptoglobin.	Iron	83-87	haptoglobin	Bos taurus	122-133
8902231-16	1996	The association of RBP and TF concentrations with AP in various maternal and conceptus compartments during pregnancy is consistent with the hypothesis that one function of these two proteins may be to protect maternal and fetal tissues from lipid peroxidation that is a possible consequence of iron transport via endometrial secretion of UF.	Iron	294-298	retinol binding protein 4	Sus scrofa	19-22
8849692-3	1996	Three antibodies, 2 IgG1 and 1 IgG2a, were found to bind both Fe(ToCPP) and the free base ToCPPH2 with similar binding constants.	Iron	62-64	LOC105243590	Mus musculus	20-30
8849692-9	1996	studies have shown that the two IgG1-Fe(ToCPP) complexes were high-spin hexacoordinate iron(III) complexes, with no amino acid residue binding the iron, whereas the IgG2a-Fe(ToCPP) complex was a low-spin hexacoordinate iron(III) complex with two strong ligands binding the iron atom.	Iron	87-91	LOC105243590	Mus musculus	32-36
8849692-9	1996	studies have shown that the two IgG1-Fe(ToCPP) complexes were high-spin hexacoordinate iron(III) complexes, with no amino acid residue binding the iron, whereas the IgG2a-Fe(ToCPP) complex was a low-spin hexacoordinate iron(III) complex with two strong ligands binding the iron atom.	Iron	37-39	LOC105243590	Mus musculus	32-36
8849692-10	1996	Both IgG1-Fe(ToCPP) complexes were found to catalyze the oxidation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) 5-fold more efficiently than Fe(ToCPP) alone whereas the binding of IgG2a to this iron-porphyrin had no effect on its catalytic activity.	Iron	10-12	LOC105243590	Mus musculus	5-9
9004443-1	1996	The 37 kDa iron-repressible protein, Fbp, was purified from two Neisseria meningitidis strains by metal-affinity chromatography and used to obtain mouse monospecific polyclonal immune sera.	Iron	11-15	far upstream element (FUSE) binding protein 1	Mus musculus	37-40
8905919-4	1996	The proton nmr longitudinal relaxation rate study indicated that the paramagnetic effects of the haem iron of CYP1A2 were observed in protons of enoxacin with a 1,8-naphthyridine skeleton and its 4"-nitrogen atom on the 7-piperazine ring probably participated in specific binding to the haem iron.	Iron	102-106	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	110-116
8905919-4	1996	The proton nmr longitudinal relaxation rate study indicated that the paramagnetic effects of the haem iron of CYP1A2 were observed in protons of enoxacin with a 1,8-naphthyridine skeleton and its 4"-nitrogen atom on the 7-piperazine ring probably participated in specific binding to the haem iron.	Iron	292-296	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	110-116
8822950-2	1996	Tartrate-resistant acid phosphatase (TRAP) is an iron-containing protein encoded by the same gene that codes for uteroferrin, a placental iron transport protein.	Iron	49-53	TRAP	Homo sapiens	37-41
8822950-2	1996	Tartrate-resistant acid phosphatase (TRAP) is an iron-containing protein encoded by the same gene that codes for uteroferrin, a placental iron transport protein.	Iron	138-142	TRAP	Homo sapiens	37-41
8781450-0	1996	A novel mutation in the iron responsive element of ferritin L-subunit gene as a cause for hereditary hyperferritinemia-cataract syndrome.	Iron	24-28	ferritin light chain	Homo sapiens	51-69
8877717-2	1996	Tetrameric antibody complexes targeted against the CD8 antigen were used to bind colloidal superparamagnetic dextran-iron particles to the desired cells with very low nonspecific binding.	Iron	117-121	CD8a molecule	Homo sapiens	51-54
10062425-0	1996	Exchange-Coupled Spin-Fluctuation Theory: Application to Fe, Co, and Ni.	Iron	57-59	spindlin 1	Homo sapiens	17-21
8670839-0	1996	Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast.	Iron	0-4	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	34-38
8670839-0	1996	Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast.	Iron	60-64	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	34-38
8670839-6	1996	In vivo footprinting demonstrated occupancy of the AFT1 binding site in cells deprived of iron and not in cells grown in the presence of iron.	Iron	90-94	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	51-55
8670839-7	1996	Thus, the environmental signal resulting from iron deprivation was transduced through the regulated binding of AFT1 to the FET3 promoter, followed by the activation of transcription.	Iron	13-17	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	111-115
8675166-7	1996	The number of MIB1-positive cells correlated directly with alanine transaminase (ALT) levels, Knodell index (KI), and, inversely, with iron saturation.	Iron	135-139	MIB E3 ubiquitin protein ligase 1	Homo sapiens	14-18
8655539-8	1996	An A. brasilense mutant, with Tn5 inserted in the lon gene, was shown to be defective in iron uptake and failed to express two membrane proteins that are induced by iron starvation in the parental strain.	Iron	89-93	putative ATP-dependent Lon protease	Escherichia coli	50-53
8654562-4	1996	These results are discussed in terms of the light-induced formation of a bound OH" radical shared between the Cyt b-559 heme Fe and the Mn cluster as a first step of water oxidation.	Iron	125-127	mitochondrially encoded cytochrome b	Homo sapiens	110-115
8643505-9	1996	Our results identify a regulatory link between energy and iron metabolism in vertebrates and invertebrates, and suggest biological functions for the IRE/IRP regulatory system in addition to the maintenance of iron homeostasis.	Iron	58-62	ire	Drosophila melanogaster	149-152
8643505-9	1996	Our results identify a regulatory link between energy and iron metabolism in vertebrates and invertebrates, and suggest biological functions for the IRE/IRP regulatory system in addition to the maintenance of iron homeostasis.	Iron	58-62	Iron regulatory protein 1A	Drosophila melanogaster	153-156
8643505-9	1996	Our results identify a regulatory link between energy and iron metabolism in vertebrates and invertebrates, and suggest biological functions for the IRE/IRP regulatory system in addition to the maintenance of iron homeostasis.	Iron	209-213	ire	Drosophila melanogaster	149-152
8643505-9	1996	Our results identify a regulatory link between energy and iron metabolism in vertebrates and invertebrates, and suggest biological functions for the IRE/IRP regulatory system in addition to the maintenance of iron homeostasis.	Iron	209-213	Iron regulatory protein 1A	Drosophila melanogaster	153-156
8639920-1	1996	Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures known as iron-responsive elements (IREs).	Iron	109-113	iron responsive element binding protein 2	Rattus norvegicus	35-39
8639920-4	1996	IRP1 and IRP2 binding activities are regulated by intracellular iron levels.	Iron	64-68	iron responsive element binding protein 2	Rattus norvegicus	9-13
8607802-5	1996	Evidence is also provided that an approximately 50% diminution of the total iron content in the tissue, which follows the in vivo administration of the iron chelator desferrioxamine (DESF), reduces the amount of MnSOD induction achieved by DDC treatment.	Iron	76-80	superoxide dismutase 2	Rattus norvegicus	212-217
8607802-5	1996	Evidence is also provided that an approximately 50% diminution of the total iron content in the tissue, which follows the in vivo administration of the iron chelator desferrioxamine (DESF), reduces the amount of MnSOD induction achieved by DDC treatment.	Iron	152-156	superoxide dismutase 2	Rattus norvegicus	212-217
8605990-1	1996	The labile iron pool of cells (LIP) constitutes the primary source of metabolic and catalytically reactive iron in the cytosol.	Iron	11-15	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	31-34
8605990-1	1996	The labile iron pool of cells (LIP) constitutes the primary source of metabolic and catalytically reactive iron in the cytosol.	Iron	107-111	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	31-34
8605990-5	1996	We show that the capacity of K562 cells to adjust LIP levels is highly dependent on the origin of the LIP increase and on the pre-existing cellular iron status.	Iron	148-152	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	50-53
8599111-2	1996	Two proteins in the plasma membrane of yeast--a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene--were shown to mediate high-affinity iron uptake.	Iron	173-177	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	126-130
8599111-5	1996	FTR1 protein also played a direct role in iron transport.	Iron	42-46	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	0-4
8599111-6	1996	Mutations in a conserved sequence motif of FTR1 specifically blocked iron transport.	Iron	69-73	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	43-47
9118599-1	1996	Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Gwynedd, Wales, UK which contains approximately 0.3 mg of iron per ml as ferrous sulphate.	Iron	8-12	surfactant protein A2	Homo sapiens	0-3
9118599-1	1996	Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Gwynedd, Wales, UK which contains approximately 0.3 mg of iron per ml as ferrous sulphate.	Iron	141-145	surfactant protein A2	Homo sapiens	0-3
8643666-0	1996	beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism.	Iron	40-44	hemoglobin, beta adult minor chain	Mus musculus	0-5
8643666-0	1996	beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism.	Iron	132-136	hemoglobin, beta adult minor chain	Mus musculus	0-5
8643666-0	1996	beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism.	Iron	132-136	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	75-82
8643666-2	1996	We have identified a multigene system in the murine MHC that contains excellent candidates for the murine equivalent of the human HC locus and implicate nonclassical class I genes in the control of iron absorption.	Iron	198-202	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	166-173
8643666-6	1996	At least one of these nonclassical class I genes, Q2, is expressed in the gastrointestinal tract, the primary site of iron absorption.	Iron	118-122	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	35-42
8643666-9	1996	As a test of this hypothesis, we predicted that mice which have altered expression of class I gene products, the beta2-microglobulin knockout mice, [beta2m(-/-)], would develop Fe overload.	Iron	177-179	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	86-93
8969812-0	1996	Effect of chronic erythropoietin administration on plasma iron in newborn lambs.	Iron	58-62	erythropoietin	Ovis aries	18-32
8843957-3	1996	The aim of this study was to examine the effect of iron on the synthesis of (ALAS-E) mRNA and (ALAS-N) mRNA.	Iron	51-55	aminolevulinic acid synthase 2, erythroid	Mus musculus	77-83
8843957-4	1996	This effect was compared with the effect of iron on the iron on the synthesis of H-ferritin and transferrin receptor mRNAs.	Iron	56-60	transferrin	Mus musculus	96-107
8843957-5	1996	Incubation of uninduced or induced MEL cells with iron chelator pyridoxal isonicotinoyl hydrazone (PIH) or desferrioxamine (Desferal) and 3H-uridine decreased the level of the 3H-labeled (ALAS-E) mRNA.	Iron	50-54	aminolevulinic acid synthase 2, erythroid	Mus musculus	188-194
8843957-8	1996	These findings indicate that iron might play its role also at the pretranslational level of the expression of ALAS-E or in the stability of (ALAS-E) mRNA.	Iron	29-33	aminolevulinic acid synthase 2, erythroid	Mus musculus	110-116
8843957-8	1996	These findings indicate that iron might play its role also at the pretranslational level of the expression of ALAS-E or in the stability of (ALAS-E) mRNA.	Iron	29-33	aminolevulinic acid synthase 2, erythroid	Mus musculus	141-147
8677190-7	1996	Spa therapy for 20 days in Wysowa was accompanied by a significant increase of plasma erythropoietin, iron, ferritin and saturation of transferrin with iron and by an increase of blood haemoglobin and haematocrit value.	Iron	102-106	surfactant protein A2	Homo sapiens	0-3
8677190-7	1996	Spa therapy for 20 days in Wysowa was accompanied by a significant increase of plasma erythropoietin, iron, ferritin and saturation of transferrin with iron and by an increase of blood haemoglobin and haematocrit value.	Iron	152-156	surfactant protein A2	Homo sapiens	0-3
8677190-10	1996	Spa therapy exerts a stimulatory effect on erythropoiesis caused, among other factors, by increased erythropoietin secretion and iron mobilization.	Iron	129-133	surfactant protein A2	Homo sapiens	0-3
7478533-7	1995	The same conclusion was reached when the stability of a c-fos mRNA devoid of ARE was assessed in function of iron availability.	Iron	109-113	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-61
7592847-0	1995	Characterization of the iron-binding site in mammalian ferrochelatase by kinetic and Mossbauer methods.	Iron	24-28	ferrochelatase	Homo sapiens	55-69
8535522-0	1995	Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae.	Iron	54-58	Cad1p	Saccharomyces cerevisiae S288C	35-39
8535522-0	1995	Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae.	Iron	54-58	Cad1p	Saccharomyces cerevisiae S288C	40-44
8535522-4	1995	The growth rate of cells in iron-deficient conditions and their ferrireductase activity in the absence of added cadmium were also strongly affected by the dosage of YAP1 and CAD1/YAP2 genes.	Iron	28-32	Cad1p	Saccharomyces cerevisiae S288C	174-178
8535522-4	1995	The growth rate of cells in iron-deficient conditions and their ferrireductase activity in the absence of added cadmium were also strongly affected by the dosage of YAP1 and CAD1/YAP2 genes.	Iron	28-32	Cad1p	Saccharomyces cerevisiae S288C	179-183
7583532-1	1995	Involvement of nuclear factor-kappa B. Minimally modified LDL (MM-LDL), obtained by mild iron oxidation or prolonged storage at 4 degrees C, has been shown to induce the expression of macrophage-colony stimulating factor (M-CSF) in cultured aortic endothelial cells.	Iron	89-93	colony stimulating factor 1 (macrophage)	Mus musculus	184-220
7558284-1	1995	Haemophilus influenzae has the ability to obtain iron from human transferrin via two bacterial cell surface transferrin binding proteins, Tbp1 and Tbp2.	Iron	49-53	EGFLAM antisense RNA 3	Homo sapiens	138-142
7575558-0	1995	Ferrochelatase binds the iron-responsive element present in the erythroid 5-aminolevulinate synthase mRNA.	Iron	25-29	ferrochelatase	Homo sapiens	0-14
7544575-0	1995	Nitric oxide-mediated inactivation of mammalian ferrochelatase in vivo and in vitro: possible involvement of the iron-sulphur cluster of the enzyme.	Iron	113-117	ferrochelatase	Homo sapiens	48-62
7641199-1	1995	Synergistic inhibition of hematopoietic tumor growth can be observed in vitro when the iron chelator deferoxamine (DFO) is used in combination with an IgG mAb against the anti-transferrin receptor antibody (ATRA).	Iron	87-91	transferrin	Mus musculus	176-187
7472784-2	1995	These conditions all have in common high levels of cytotoxic non-transferrin-bound serum iron.	Iron	89-93	transferrin	Mus musculus	65-76
9979723-0	1995	Spin-polarized Auger-electron diffraction study of the magnetic poisoning of Fe(001) by sulfur.	Iron	77-79	spindlin 1	Homo sapiens	0-4
8578805-1	1995	During iron-limited growth Neisseria meningitidis expresses two transferrin binding proteins, TBP1 and TBP2, with molecular masses of approximately 98 and 65-90 kDa depending on strain.	Iron	7-11	EGFLAM antisense RNA 3	Homo sapiens	94-98
7636385-6	1995	This indicates that transferrin saturation with iron, but not the serum level of transferrin, is likely to be genetically determined in mice.	Iron	48-52	transferrin	Mus musculus	20-31
7636385-9	1995	When mice were challenged with a high-iron diet, the concentration of carbonyl iron required to completely saturate transferrin with iron was 10 times greater for C57BL/6 and BALB/c mice than for DBA/2 and AKR mice.	Iron	79-83	transferrin	Mus musculus	116-127
7636385-9	1995	When mice were challenged with a high-iron diet, the concentration of carbonyl iron required to completely saturate transferrin with iron was 10 times greater for C57BL/6 and BALB/c mice than for DBA/2 and AKR mice.	Iron	79-83	transferrin	Mus musculus	116-127
7543092-5	1995	Reaction of recombinant nNOS with phenyldiazene produces a phenyl-iron (Fe.Ph) complex with a maximum at 470 nm.	Iron	72-74	nitric oxide synthase 1	Rattus norvegicus	24-28
7737636-0	1995	Kupffer cell iron overload induces intercellular adhesion molecule-1 expression on hepatocytes in genetic hemochromatosis.	Iron	13-17	intercellular adhesion molecule 1	Homo sapiens	35-68
7737636-13	1995	Thus, in patients with untreated genetic hemochromatosis and Kupffer cell iron overload, hepatocytes occasionally express ICAM-1.	Iron	74-78	intercellular adhesion molecule 1	Homo sapiens	122-128
7650542-1	1995	It has been suggested that iron-carrying transferrin exerts growth-factor-like influences on motor neurons.	Iron	27-31	transferrin	Mus musculus	41-52
7727409-1	1995	Human tyrosine hydroxylase isoform 1 (hTH1) was expressed in Escherichia coli, purified as the apoenzyme, and reconstituted with iron.	Iron	129-133	negative elongation factor complex member C/D	Homo sapiens	38-42
7713877-1	1995	Phagocytic cytochrome b558 is a unique heme-containing enzyme, which catalyzes one electron reduction of molecular oxygen to produce a superoxide anion with a six-coordinated heme iron.	Iron	180-184	mitochondrially encoded cytochrome b	Homo sapiens	11-23
7728949-14	1995	Similarly, weanling mice with a dominantly diploid cell population, when treated with iron (300 mg/kg), exhibited a significant shift to a tetraploid (4N) population and a marked increase in proliferation as measured by BrdU incorporation and proliferative cell nuclear antigen (PCNA) detection.	Iron	86-90	proliferating cell nuclear antigen	Mus musculus	279-283
7610931-7	1995	Transferrin-bound iron increased P1 promoter activity 2.5-fold and hemin decreased P1 promoter activity, but neither had any effect on P2 activity.	Iron	18-22	transferrin	Mus musculus	0-11
7610931-8	1995	These data show that the transcriptional regulation of the TRAP gene is complex and that iron may play a key role in TRAP gene regulation.	Iron	89-93	acid phosphatase 5, tartrate resistant	Mus musculus	59-63
7610931-8	1995	These data show that the transcriptional regulation of the TRAP gene is complex and that iron may play a key role in TRAP gene regulation.	Iron	89-93	acid phosphatase 5, tartrate resistant	Mus musculus	117-121
7720713-0	1995	AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae.	Iron	20-24	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	0-4
7720713-1	1995	Using a scheme for selecting mutants of Saccharomyces cerevisiae with abnormalities of iron metabolism, we have identified a gene, AFT1, that mediates the control of iron uptake.	Iron	87-91	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	131-135
7720713-1	1995	Using a scheme for selecting mutants of Saccharomyces cerevisiae with abnormalities of iron metabolism, we have identified a gene, AFT1, that mediates the control of iron uptake.	Iron	166-170	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	131-135
7720713-4	1995	A dominant mutant allele of this gene, termed AFT1-1up, results in high levels of ferric reductase and ferrous iron uptake that are not repressed by exogenous iron.	Iron	111-115	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	46-50
7720713-4	1995	A dominant mutant allele of this gene, termed AFT1-1up, results in high levels of ferric reductase and ferrous iron uptake that are not repressed by exogenous iron.	Iron	159-163	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	46-50
9979071-0	1995	Spin-dependent transmission of polarized electrons through a ferromagnetic iron film.	Iron	75-79	spindlin 1	Homo sapiens	0-4
7659183-1	1995	The levels of iron-responsive element-binding protein (IRE-BP I) mRNA throughout the course of erythroid differentiation were investigated in several lines of murine erythroleukemia (MEL) cells (Friend 745, 707 and Fw cells).	Iron	14-18	aconitase 1	Mus musculus	55-61
8001836-4	1994	Free radical stress induced by iron/ascorbate treatment has a rigidizing effect on the protein infrastructure of these membranes, as appraised by EPR analysis of membrane protein-bound spin label, but no change was detected in the lipid component of the membrane.	Iron	31-35	spindlin 1	Homo sapiens	185-189
8077204-10	1994	The results suggest that the C-terminal peptide of adrenodoxin, especially proline 108, affects the structural integrity of the iron-sulfur cluster and that electron donation from adrenodoxin to CYP11A1 and CYP11B1 is determined at least in part by different features of the cytochromes.	Iron	128-132	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	207-214
7860417-4	1994	A mutant mouse model that lacks the ability to synthesize transferrin is defective in spermatogenesis and may help to delineate the nature of the iron requirement by germ cells.	Iron	146-150	transferrin	Mus musculus	58-69
7517354-3	1994	The 5" untranslated region (UTR) of the soma ferritin mRNA contains a 28-bp element which shows 64% sequence identity with the iron-responsive element (IRE) of vertebrate ferritin mRNAs.	Iron	127-131	Fer2	Triticum aestivum	45-53
7517354-3	1994	The 5" untranslated region (UTR) of the soma ferritin mRNA contains a 28-bp element which shows 64% sequence identity with the iron-responsive element (IRE) of vertebrate ferritin mRNAs.	Iron	127-131	Fer2	Triticum aestivum	171-179
8200442-2	1994	The in vivo spin-trapping of .NO was performed by injecting into mice a metal-chelator complex, consisting of N-methyl-D-glucamine dithiocarbamate (MGD) and reduced iron (Fe2+), that binds to .NO and forms a stable, water-soluble [(MGD)2-Fe(2+)-NO] complex, and by monitoring continuously the in vivo formation of the latter complex using an S-band EPR spectrometer.	Iron	165-169	spindlin 1	Mus musculus	12-16
8188678-7	1994	Mutagenesis and deletion of the highly conserved lipoxygenase C-terminal isoleucine (Ile663), a residue believed to be involved in the non-heme iron atom coordination of all lipoxygenases, was performed.	Iron	144-148	linoleate 9S-lipoxygenase-4	Glycine max	49-61
8188678-10	1994	These findings would tend to indicate a stringent requirement for the proper spatial alignment and folding of the C-terminal chain back into the core of the enzyme to interact with the iron atom by analogy with the recently determined crystal structure of a soybean lipoxygenase (Boyington, J. C., Gaffney, B. J., and Amzel, L. M. (1993) Science 260, 1482-1486).	Iron	185-189	linoleate 9S-lipoxygenase-4	Glycine max	266-278
8020628-0	1994	Haemochromatosis as a window into the study of the immunological system: a novel correlation between CD8+ lymphocytes and iron overload.	Iron	122-126	CD8a molecule	Homo sapiens	101-104
8020628-5	1994	A significant positive correlation between CD4/CD8 ratios and the amount of iron mobilised by phlebotomy was found during this study.	Iron	76-80	CD8a molecule	Homo sapiens	47-50
8020628-6	1994	A novel correlation between the relative proportions of CD4+ and CD8+ cells and iron overload is confirmed by the follow-up of iron re-entry in the serum transferrin pool in the treated patients.	Iron	80-84	CD8a molecule	Homo sapiens	65-68
8020628-6	1994	A novel correlation between the relative proportions of CD4+ and CD8+ cells and iron overload is confirmed by the follow-up of iron re-entry in the serum transferrin pool in the treated patients.	Iron	127-131	CD8a molecule	Homo sapiens	65-68
8191217-9	1994	Decreased CD8-p56lck activity was seen both in patients undergoing intensive phlebotomy treatment and in patients in maintenance therapy (i.e. patients who had reached normal levels of iron stores), indicating that this abnormality does not appear to be corrected by iron depletion.	Iron	185-189	CD8a molecule	Homo sapiens	10-13
8191217-9	1994	Decreased CD8-p56lck activity was seen both in patients undergoing intensive phlebotomy treatment and in patients in maintenance therapy (i.e. patients who had reached normal levels of iron stores), indicating that this abnormality does not appear to be corrected by iron depletion.	Iron	267-271	CD8a molecule	Homo sapiens	10-13
8142401-5	1994	In reactions started with mixtures of iron(II) and iron(III) lipoxygenase, r(init) is linearly related to the initial concentration of the Fe (III) enzyme form.	Iron	38-42	linoleate 9S-lipoxygenase-4	Glycine max	61-73
8147916-9	1994	All tissues examined have a considerable potential capacity for uptake of non-transferrin-bound iron, this being greatest in liver and renal cortex.	Iron	96-100	transferrin	Mus musculus	78-89
8125919-4	1994	Only the C-fragment was found capable of donating iron to hepatoma-derived HuH-7 cells or of binding to surface receptors of HuH-7 and leukemic K562 cells.	Iron	50-54	MIR7-3 host gene	Homo sapiens	75-80
8120006-7	1994	Western blot analysis of SDH4 disruption mutant membrane fractions indicates that membrane attachment of the flavoprotein and iron-sulfur subunits is impaired but not abolished.	Iron	126-130	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	25-29
8120006-9	1994	These findings indicate that Sdh4p contributes both to the membrane attachment of the catalytic flavoprotein and iron-sulfur subunits and to electron transfer to ubiquinone.	Iron	113-117	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	29-34
8132151-4	1994	Additionally, the level of spvR expression was controlled by the availability of iron, activity being greatest under low iron conditions in stationary phase.	Iron	81-85	plasmid virulence regulator protein	Salmonella enterica subsp. enterica serovar Dublin	27-31
8132151-4	1994	Additionally, the level of spvR expression was controlled by the availability of iron, activity being greatest under low iron conditions in stationary phase.	Iron	121-125	plasmid virulence regulator protein	Salmonella enterica subsp. enterica serovar Dublin	27-31
8306995-4	1994	The deduced human ETF-QO sequence predicts a protein containing 617 amino acids (67 kDa), two domains associated with the binding of the AMP moiety of the FAD prosthetic group, two membrane helices and a motif containing four cysteine residues that is frequently associated with the liganding of ferredoxin-like iron-sulfur clusters.	Iron	312-316	electron transfer flavoprotein dehydrogenase	Homo sapiens	18-24
8276824-2	1994	Ferrochelatase (EC 4.99.1.1) catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX.	Iron	108-120	ferrochelatase	Homo sapiens	0-14
8276824-2	1994	Ferrochelatase (EC 4.99.1.1) catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX.	Iron	108-120	ferrochelatase	Homo sapiens	16-27
8305467-4	1994	The retinal oxidase is a metalloflavoenzyme containing 2 FADs as the coenzyme, and 8 irons, 2 molybdenums, 2 disulfide bonds and 8 inorganic sulfurs.	Iron	85-90	aldehyde oxidase 1	Oryctolagus cuniculus	4-19
8279451-7	1994	Energy dispersive x-ray analysis and TEM demonstrated iron and calcium on the microfibrillar portion of elastin.	Iron	54-58	elastin	Homo sapiens	104-111
8140137-1	1994	Part 6: Spectrophotometric determination of micromolar concentrations of iron (II) and iron (III) in anti-anemic formulations using a newly prepared Schiff"s base.	Iron	73-77	tankyrase 2	Homo sapiens	0-6
8140137-1	1994	Part 6: Spectrophotometric determination of micromolar concentrations of iron (II) and iron (III) in anti-anemic formulations using a newly prepared Schiff"s base.	Iron	87-91	tankyrase 2	Homo sapiens	0-6
7505388-0	1993	The GEF1 gene of Saccharomyces cerevisiae encodes an integral membrane protein; mutations in which have effects on respiration and iron-limited growth.	Iron	131-135	Gef1p	Saccharomyces cerevisiae S288C	4-8
7505388-4	1993	Gef1- mutants also fail to grow on a fermentable carbon source, glucose, when iron is reduced to low concentrations in the medium, suggesting that the GEF1 gene is required for efficient metabolism of iron during growth on fermentable as well as respired carbon sources.	Iron	78-82	Gef1p	Saccharomyces cerevisiae S288C	0-4
7505388-4	1993	Gef1- mutants also fail to grow on a fermentable carbon source, glucose, when iron is reduced to low concentrations in the medium, suggesting that the GEF1 gene is required for efficient metabolism of iron during growth on fermentable as well as respired carbon sources.	Iron	78-82	Gef1p	Saccharomyces cerevisiae S288C	151-155
7505388-4	1993	Gef1- mutants also fail to grow on a fermentable carbon source, glucose, when iron is reduced to low concentrations in the medium, suggesting that the GEF1 gene is required for efficient metabolism of iron during growth on fermentable as well as respired carbon sources.	Iron	201-205	Gef1p	Saccharomyces cerevisiae S288C	0-4
7505388-4	1993	Gef1- mutants also fail to grow on a fermentable carbon source, glucose, when iron is reduced to low concentrations in the medium, suggesting that the GEF1 gene is required for efficient metabolism of iron during growth on fermentable as well as respired carbon sources.	Iron	201-205	Gef1p	Saccharomyces cerevisiae S288C	151-155
7505388-11	1993	We suggest that GEF1 encodes a transport protein that is involved in intracellular iron metabolism.	Iron	83-87	Gef1p	Saccharomyces cerevisiae S288C	16-20
12271059-0	1993	Newly Imported Rieske Iron-Sulfur Protein Associates with Both Cpn60 and Hsp70 in the Chloroplast Stroma.	Iron	22-26	heat shock protein family D (Hsp60) member 1	Homo sapiens	63-68
12271059-0	1993	Newly Imported Rieske Iron-Sulfur Protein Associates with Both Cpn60 and Hsp70 in the Chloroplast Stroma.	Iron	22-26	heat shock protein family A (Hsp70) member 4	Homo sapiens	73-78
8213767-7	1993	These studies suggest that iron, using vesicles as means of transport, moves from the effete red cells inside the macrophage to the outside possibly bound to transferrin.	Iron	27-31	transferrin	Mus musculus	158-169
8408820-1	1993	Erythropoietic protoporphyria is an inherited disorder characterized biochemically by a deficiency of ferrochelatase, the enzyme that catalyzes the incorporation of ferrous iron into protoporphyrin to form heme.	Iron	165-177	ferrochelatase	Homo sapiens	102-116
8413301-2	1993	While recent reports have clearly demonstrated that GATA-1 is involved in the induction of erythroid cell-specific forms of 5-aminolevulinate synthase (ALAS-2) and porphobilinogen (PBG) deaminase and that cellular iron status plays a regulatory role for ALAS-2, little is known about regulation of the remainder of the pathway.	Iron	214-218	aminolevulinic acid synthase 2, erythroid	Mus musculus	152-158
8415693-5	1993	In support, cultured endothelial cells exposed to methemoglobin--in contrast to exposure to ferrohemoglobin, cytochrome c, or metmyoglobin--rapidly increased their heme oxygenase mRNA and enzyme activity, thereby supporting heme uptake; ferritin production was also markedly increased after such exposure, thus attesting to eventual incorporation of Fe.	Iron	350-352	hemoglobin subunit gamma 2	Homo sapiens	50-63
8415693-7	1993	If the endothelium is exposed to methemoglobin for a more prolonged period (16 hr), it accumulates large amounts of ferritin; concomitantly, and presumably associated with iron sequestration by this protein, the endothelium converts from hypersusceptible to hyperresistant to oxidative damage.	Iron	172-176	hemoglobin subunit gamma 2	Homo sapiens	33-46
8360174-7	1993	High level production of either CAD1 or yAP-1 causes cells to acquire a pleiotropic drug-resistant phenotype and to be able to tolerate normally toxic levels of iron chelators and zinc.	Iron	161-165	Cad1p	Saccharomyces cerevisiae S288C	32-36
8377118-1	1993	Plasma iron mobilization by endogenous erythropoietin in the sheep fetus; evidence of threshold response in spontaneous hypoxemia.	Iron	7-11	erythropoietin	Ovis aries	39-53
8367880-2	1993	Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the major plasma transport protein for Al and Mn as well as Fe.	Iron	154-156	transferrin	Mus musculus	72-83
8401297-0	1993	Enhanced c-fos expression after intracellular iron deprivation.	Iron	46-50	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-14
8401297-1	1993	Intracellular iron deprivation by deferoxamine treatment, which leads to cells arrest in the S phase, enhanced c-fos expression in the neuroblastoma cell line, IMR32.	Iron	14-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-116
8401297-2	1993	The c-fos expression of iron deprived cells retained its response to stimulation by TPA, and cytosolic PKC activity did not decline after iron deprivation.	Iron	24-28	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
8401297-5	1993	Iron deprivation may activate the growth-related oncogene, c-fos, through some means other than the PKC pathway.	Iron	0-4	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-64
7687131-0	1993	Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo.	Iron	118-122	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	174-178
7687131-1	1993	The orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20) proposed for reduction of iron overload in hemoglobinopathic patients, was studied in rats with respect to its ability to interfere with dopamine (DA) and serotonin (5-HT) metabolism.	Iron	18-22	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	74-78
7687131-1	1993	The orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20) proposed for reduction of iron overload in hemoglobinopathic patients, was studied in rats with respect to its ability to interfere with dopamine (DA) and serotonin (5-HT) metabolism.	Iron	106-110	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	74-78
10005524-0	1993	Spin-polarized surface states of Fe(100).	Iron	33-35	spindlin 1	Homo sapiens	0-4
8490018-5	1993	Iron administration to transgenic mice resulted in a significant decrease of transferrin-directed CAT enzyme activity and CAT protein in liver, but no significant decrease in human transferrin-CAT mRNA levels.	Iron	0-4	transferrin	Mus musculus	77-88
8497198-2	1993	It is structurally-related to CRP (the cyclic AMP receptor protein) except for the presence of a cysteine-rich N-terminal extension, which may form part of an iron-binding, redox-sensing domain in FNR.	Iron	159-163	catabolite gene activator protein	Escherichia coli	30-33
8497198-2	1993	It is structurally-related to CRP (the cyclic AMP receptor protein) except for the presence of a cysteine-rich N-terminal extension, which may form part of an iron-binding, redox-sensing domain in FNR.	Iron	159-163	catabolite gene activator protein	Escherichia coli	39-66
8436123-0	1993	Reduction and mobilization of iron by a NAD(P)H:flavin oxidoreductase from Escherichia coli.	Iron	30-34	oxidoreductase	Escherichia coli	55-69
8489770-2	1993	Porphyrin accumulation decreased in the presence of iron, and the iron-mediated decrease was partially reversed by CaMg EDTA (1.25-10.0 mM), suggesting that there is functionally active ferrochelatase in these cells.	Iron	52-56	ferrochelatase	Mus musculus	186-200
8489770-2	1993	Porphyrin accumulation decreased in the presence of iron, and the iron-mediated decrease was partially reversed by CaMg EDTA (1.25-10.0 mM), suggesting that there is functionally active ferrochelatase in these cells.	Iron	66-70	ferrochelatase	Mus musculus	186-200
10046885-0	1992	Spin polarization of epitaxial Cr on Fe(001) and interlayer magnetic coupling in Fe/Cr multilayered structures.	Iron	37-39	spindlin 1	Homo sapiens	0-4
10046885-0	1992	Spin polarization of epitaxial Cr on Fe(001) and interlayer magnetic coupling in Fe/Cr multilayered structures.	Iron	81-83	spindlin 1	Homo sapiens	0-4
1288876-7	1992	Iron chelators (desferrioxamine or pyridoxal isonicotinoylhydrazone) reduced and iron donors (iron bound to transferrin or pyridoxal isonicotinoylhydrazone) enhanced mRNA synthesis for ferrochelatase.	Iron	81-85	ferrochelatase	Mus musculus	185-199
1288876-7	1992	Iron chelators (desferrioxamine or pyridoxal isonicotinoylhydrazone) reduced and iron donors (iron bound to transferrin or pyridoxal isonicotinoylhydrazone) enhanced mRNA synthesis for ferrochelatase.	Iron	94-98	transferrin	Mus musculus	108-119
1288876-7	1992	Iron chelators (desferrioxamine or pyridoxal isonicotinoylhydrazone) reduced and iron donors (iron bound to transferrin or pyridoxal isonicotinoylhydrazone) enhanced mRNA synthesis for ferrochelatase.	Iron	94-98	ferrochelatase	Mus musculus	185-199
1423854-0	1992	Search for Ha-ras codon 61 mutations in liver tumours caused by hexachlorobenzene and Aroclor 1254 in C57BL/10ScSn mice with iron overload.	Iron	125-129	Harvey rat sarcoma virus oncogene	Mus musculus	11-17
1356768-4	1992	Combining visible spectroscopy and equilibrium-binding studies, it was found that catecholamines bind to hTH1 and hTH2 with a stoichiometry of about 1.0 mol/mol enzyme subunit, interacting with the catalytic iron at the active site.	Iron	208-212	negative elongation factor complex member C/D	Homo sapiens	105-109
1357003-12	1992	Thus, adherence dependent on Mac-1 (CD11b/CD18) and ICAM-1 (CD54) activates the neutrophil respiratory burst resulting in a highly compartmented iron-dependent myocyte oxidative injury.	Iron	145-149	intercellular adhesion molecule 1	Canis lupus familiaris	52-58
1511440-0	1992	GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/iron are consistent with oxidative damage to DNA.	Iron	133-137	KRAS proto-oncogene, GTPase	Rattus norvegicus	44-49
1511440-4	1992	Selective oligonucleotide hybridization analysis of K-ras gene sequences amplified by polymerase chain reaction revealed that 1 of 12 primary tumors induced with Ni3S2 and 7 of 9 primary tumors induced with Ni3S2/iron contained exclusively GGT to GTT activating mutations in codon 12.	Iron	213-217	KRAS proto-oncogene, GTPase	Rattus norvegicus	52-57
10002305-0	1992	Spin-polarized interface states at the Pd(111)/Fe(110), Pd(111)/Co(0001), and Pt(111)/Co(0001) interfaces.	Iron	47-49	spindlin 1	Homo sapiens	0-4
1644800-0	1992	The role of the iron-sulfur cluster in Escherichia coli endonuclease III.	Iron	16-20	endonuclease III	Escherichia coli	56-72
1644800-2	1992	Resonance Raman spectroscopy has been used to investigate the function and properties of the iron-sulfur cluster in Escherichia coli endonuclease III.	Iron	93-97	endonuclease III	Escherichia coli	133-149
1388819-7	1992	This fast conversion could be extensively inhibited by previous conversion of oxyhemoglobin to methemoglobin or carbomonoxyhemoglobin, suggesting an important role of heme iron in this process.	Iron	172-176	hemoglobin subunit gamma 2	Homo sapiens	95-108
1439077-0	1992	Relationship between erythropoietic rate and iron donating capacity of the Fe/transferrin complex in mouse.	Iron	45-49	transferrin	Mus musculus	78-89
1439077-1	1992	The transfer of iron from the Fe/transferrin complex to the erythroid cells was studied in in vitro system in mice in which a drastic and opposite change in their erythropoietic activity was produced by bleeding or actinomycin D administration.	Iron	16-20	transferrin	Mus musculus	33-44
1599941-1	1992	The reversible intramolecular binding of the distal histidine side chain to the heme iron in methemoglobin is of special interest due to the very large negative reaction entropy which overcompensates the large reaction enthalpy.	Iron	85-89	hemoglobin subunit gamma 2	Homo sapiens	93-106
1611049-1	1992	Experimental hepatosis induced by intragastric administration of CCl4 was revealed to be accompanied by changes in temporal organization of lipid peroxidation, sideremia and iron excretion with urine.	Iron	174-178	chemokine (C-C motif) ligand 4	Mus musculus	65-69
1552851-0	1992	Molecular cloning, iron-regulation and mutagenesis of the irp2 gene encoding HMWP2, a protein specific for the highly pathogenic Yersinia.	Iron	19-23	iron responsive element binding protein 2	Mus musculus	58-62
1552851-3	1992	We show here that the irp2 gene is present only in the highly pathogenic strains and that its promoter is iron-regulated in Escherichia coli.	Iron	106-110	iron responsive element binding protein 2	Mus musculus	22-26
1552851-5	1992	Repressibility of irp2 by iron was restored by introduction of a plasmid carrying the fur gene.	Iron	26-30	iron responsive element binding protein 2	Mus musculus	18-22
1343225-1	1992	The photodermatosis in erythropoietic protoporphyria (EPP) is caused by the accumulation of photosensitizing protoporphyrin (PP) in the skin, due to a defect in ferrochelatase, the enzyme that inserts ferrous iron into PP to form heme.	Iron	201-213	ferrochelatase	Homo sapiens	161-175
1933870-0	1991	Ascorbic acid enhances the effects of 6-hydroxydopamine and H2O2 on iron-dependent DNA strand breaks and related processes in the neuroblastoma cell line SK-N-SH.	Iron	68-72	hedgehog acyltransferase	Homo sapiens	154-158
1933878-1	1991	Our previous studies of the mechanism of cell growth inhibition by gallium have suggested that the block in cellular iron uptake induced by transferrin-gallium results in an inhibition of the iron-dependent M2 subunit of ribonucleotide reductase.	Iron	117-121	transferrin	Mus musculus	140-151
1933878-1	1991	Our previous studies of the mechanism of cell growth inhibition by gallium have suggested that the block in cellular iron uptake induced by transferrin-gallium results in an inhibition of the iron-dependent M2 subunit of ribonucleotide reductase.	Iron	192-196	transferrin	Mus musculus	140-151
1946430-1	1991	A clone for the iron-responsive element (IRE)-binding protein (IRE-BP) has been transfected and expressed in mouse fibroblasts.	Iron	16-20	aconitase 1	Mus musculus	63-69
1930228-0	1991	Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads.	Iron	96-100	PCNA clamp associated factor	Rattus norvegicus	47-73
1930228-3	1991	The release of PAF from iron-loaded phagocytes may be due to magneto-orientational effects on membranes.	Iron	24-28	PCNA clamp associated factor	Rattus norvegicus	15-18
1850741-2	1991	Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of their potency by reducing the lipoxygenase active-site iron from the active ferric state to the inactive ferrous state.	Iron	247-251	linoleate 9S-lipoxygenase-4	Glycine max	14-26
1850741-2	1991	Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of their potency by reducing the lipoxygenase active-site iron from the active ferric state to the inactive ferrous state.	Iron	247-251	linoleate 9S-lipoxygenase-4	Glycine max	75-87
1826464-6	1991	These studies also suggest that the cell-mediated immune response in vivo, which is known to be sensitive to iron deficiency, may be evoked by effector cells which resemble TH1 clones insofar as iron metabolism is concerned.	Iron	109-113	negative elongation factor complex member C/D	Homo sapiens	173-176
1830446-2	1991	SDS-polyacrylamide gel electrophoresis in combination with immunoblot analysis showed that the bone TrATPase has a molecular weight of 33,000 D and is composed of disulfide-linked polypeptides of 20,000 and 16,000 D. The enzyme contains 1.7 mol Fe per mol enzyme.	Iron	245-247	acid phosphatase 5, tartrate resistant	Rattus norvegicus	100-108
2007131-5	1991	The presence of 1 mM phosphate during reconstitution of ferritin from apoferritin, Fe(II), and O2 accelerates the rate of oxidation of the iron 2-fold at pH 7.5.	Iron	139-143	immunoglobulin kappa variable 1D-39	Homo sapiens	83-97
16348451-0	1991	Electron Transport in the Dissimilatory Iron Reducer, GS-15.	Iron	40-44	Bet1 golgi vesicular membrane trafficking protein like	Homo sapiens	54-59
1994731-2	1991	Two observations were consistent with the postulate that the elevated levels of storage iron has in vivo immunoregulatory properties: (1) the absolute number of CD8-positive T cells were significantly elevated in untreated HH patients (n = 7) and reduced in treated patients (n = 7), as compared with controls; and (2) the proliferative response of peripheral blood mononuclear cells from untreated HH patients to mitogens was suboptimal but the response of peripheral blood mononuclear cells (PBM) from treated HH patients was normal.	Iron	88-92	CD8a molecule	Homo sapiens	161-164
1983814-0	1991	A role for mucin in the absorption of inorganic iron and other metal cations.	Iron	48-52	solute carrier family 13 member 2	Rattus norvegicus	11-16
1983814-7	1991	Iron binding to mucin occurred at acid pH and maintained the iron available for absorption with alkalinization.	Iron	0-4	solute carrier family 13 member 2	Rattus norvegicus	16-21
1983814-7	1991	Iron binding to mucin occurred at acid pH and maintained the iron available for absorption with alkalinization.	Iron	61-65	solute carrier family 13 member 2	Rattus norvegicus	16-21
1983814-9	1991	Iron competitively inhibited binding of these metals to mucin.	Iron	0-4	solute carrier family 13 member 2	Rattus norvegicus	56-61
1983814-10	1991	However, iron chelates of ascorbate, fructose, and histidine donated iron to mucin at neutral pH.	Iron	9-13	solute carrier family 13 member 2	Rattus norvegicus	77-82
1983814-11	1991	These data provided a role for gastric HCl and intestinal mucin in absorption of iron and metal cations and partial explanation of the competition for absorption between certain metals from the gut lumen.	Iron	81-85	solute carrier family 13 member 2	Rattus norvegicus	58-63
1983814-12	1991	It is postulated that intestinal mucin delivers inorganic iron to intestinal absorptive cells in an acceptable form for absorption.	Iron	58-62	solute carrier family 13 member 2	Rattus norvegicus	33-38
1772577-6	1991	Iron and zinc levels in blood and calcium in both blood and CSF of DAT patients correlated with memory and cognitive functions.	Iron	0-4	solute carrier family 6 member 3	Homo sapiens	67-70
1772577-7	1991	Iron, manganese and strontium levels of DAT sufferers in blood and aluminium in CSF were related with changes in behaviour.	Iron	0-4	solute carrier family 6 member 3	Homo sapiens	40-43
27457579-4	1991	at 4 C and 37 C. Transmission electron microscopy demonstrated that, although the CD10 MoAb-particles complex linked to the cell surface only at 4 C, they readily penetrated into cells at 37 C. In contrast, after incubation with CD8 MoAb-particles, no iron particles were seen at the cell surface, or within the cells no matter what the temperature and duration of the incubation were.	Iron	252-256	CD8a molecule	Homo sapiens	229-232
2271662-6	1990	260, 6371-6881], one of the iron ions, Fea, which is easily removed by oxidation to yield the [3Fe-4S]+ cluster of inactive aconitase, shows a dramatic change in the presence of substrate.	Iron	28-32	FEA	Homo sapiens	39-42
2390631-2	1990	The selectivity and the toxicity of the hypoxanthine/conjugated xanthine oxidase system was increased by removing the excess of conjugate and by adding chelated iron.	Iron	161-165	xanthine dehydrogenase	Mus musculus	64-80
16348226-0	1990	Anaerobic Oxidation of Toluene, Phenol, and p-Cresol by the Dissimilatory Iron-Reducing Organism, GS-15.	Iron	74-78	Bet1 golgi vesicular membrane trafficking protein like	Homo sapiens	98-103
2186090-3	1990	We hypothesized that a normal iron-containing diet might induce the transient appearance of transferrin and transferrin receptor in apical brush borders of small intestinal absorptive cells in a normal mouse that was provided iron-containing chow until the moment of sacrifice.	Iron	30-34	transferrin	Mus musculus	92-103
2186090-3	1990	We hypothesized that a normal iron-containing diet might induce the transient appearance of transferrin and transferrin receptor in apical brush borders of small intestinal absorptive cells in a normal mouse that was provided iron-containing chow until the moment of sacrifice.	Iron	30-34	transferrin	Mus musculus	108-119
2186090-3	1990	We hypothesized that a normal iron-containing diet might induce the transient appearance of transferrin and transferrin receptor in apical brush borders of small intestinal absorptive cells in a normal mouse that was provided iron-containing chow until the moment of sacrifice.	Iron	226-230	transferrin	Mus musculus	92-103
2186090-3	1990	We hypothesized that a normal iron-containing diet might induce the transient appearance of transferrin and transferrin receptor in apical brush borders of small intestinal absorptive cells in a normal mouse that was provided iron-containing chow until the moment of sacrifice.	Iron	226-230	transferrin	Mus musculus	108-119
2310191-5	1990	On the other hand, a considerable part of tyrosyl-tRNA synthetase was converted to heat-labile forms without added iron and ascorbate under aerobic conditions but not under anaerobic conditions.	Iron	115-119	tyrosyl-tRNA synthetase 1	Rattus norvegicus	42-65
2310194-0	1990	NADPH- and adriamycin-dependent microsomal release of iron and lipid peroxidation.	Iron	54-58	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
2365344-4	1990	One week after iron supplement, the weight of the thymus and spleen in IDS group returned to normal level (P greater than 0.05), and their ADA activity also significantly increased, but ADA activity of the thymus tissue did not return to the normal.	Iron	15-19	adenosine deaminase	Rattus norvegicus	139-142
2365344-4	1990	One week after iron supplement, the weight of the thymus and spleen in IDS group returned to normal level (P greater than 0.05), and their ADA activity also significantly increased, but ADA activity of the thymus tissue did not return to the normal.	Iron	15-19	adenosine deaminase	Rattus norvegicus	186-189
2386528-2	1990	Raising the levels of intracellular iron by treatment of Friend 707 cells with either hemin, Fe-pyridoxal isonicotinoyl hydrazone (PIH) or diferric transferrin (Tf) resulted in decreased levels of the labeled TfR mRNA.	Iron	36-40	transferrin	Mus musculus	148-159
2092959-0	1990	Comparison of anti-anaemic effects of iron protein succinylate (ITF 282) and ferrous sulfate in the rat.	Iron	38-42	trefoil factor 3	Rattus norvegicus	64-67
2092959-2	1990	After a single oral administration of ITF 282, the concentration of free iron in the stomach was less than the 10% of that found after a corresponding dose of ferrous sulfate and the effect of induction of diarrhoea was significantly less important than that of ferrous sulfate.	Iron	73-77	trefoil factor 3	Rattus norvegicus	38-41
2307220-6	1990	The reduction in transferrin saturation may be attributed to the effective uptake of iron by hepatocytes simultaneously with the erythropoiesis.	Iron	85-89	transferrin	Mus musculus	17-28
2332110-7	1990	There is a statistically significant decrease of uptake of transferrin-iron under the influence of 20% ethanol in the incubation mixture (25, 50 and 100 microliters).	Iron	71-75	transferrin	Mus musculus	59-70
2332110-13	1990	All evidence indicates that the uptake of transferrin-iron from lactating mammary gland cells is not an energy dependent process.	Iron	54-58	transferrin	Mus musculus	42-53
2189166-2	1990	The critical target seems to be the enzyme heme synthetase, which is essential for the insertion of iron into the precursor, protoporphyrin IX.	Iron	100-104	ferrochelatase	Homo sapiens	43-58
33769654-5	2021	DFT calculations suggested that the anti to syn isomerization of the two high-valent Fe=O moieties has to take place via the axial rotation of one Fe=O around the Fe-O-Fe center.	Iron	85-87	synemin	Homo sapiens	44-47
33769654-5	2021	DFT calculations suggested that the anti to syn isomerization of the two high-valent Fe=O moieties has to take place via the axial rotation of one Fe=O around the Fe-O-Fe center.	Iron	147-149	synemin	Homo sapiens	44-47
33769654-5	2021	DFT calculations suggested that the anti to syn isomerization of the two high-valent Fe=O moieties has to take place via the axial rotation of one Fe=O around the Fe-O-Fe center.	Iron	147-149	synemin	Homo sapiens	44-47
33769654-5	2021	DFT calculations suggested that the anti to syn isomerization of the two high-valent Fe=O moieties has to take place via the axial rotation of one Fe=O around the Fe-O-Fe center.	Iron	147-149	synemin	Homo sapiens	44-47
33769654-8	2021	Importantly, the rigid ligand of BPMAN based diiron(III) complex 3 limits the anti to syn isomerization and axial rotation of the Fe=O moiety, which has a barrier of over 30 kcal/mol and thus accounts for the negligible catalytic activity.	Iron	130-132	synemin	Homo sapiens	86-89
33780054-0	2021	Low-Spin and High-Spin Perferryl Intermediates in Non-Heme Iron Catalyzed Oxidations of Aliphatic C-H Groups.	Iron	59-63	spindlin 1	Homo sapiens	4-8
33780054-0	2021	Low-Spin and High-Spin Perferryl Intermediates in Non-Heme Iron Catalyzed Oxidations of Aliphatic C-H Groups.	Iron	59-63	spindlin 1	Homo sapiens	18-22
33772999-2	2021	Iron (Fe) is an important micronutrient that regulates many processes in plants.	Iron	0-4	general transcription factor IIE subunit 1	Homo sapiens	6-8
33772999-4	2021	Dynamic Fe signaling in plants tightly regulates iron uptake and homeostasis.	Iron	49-53	general transcription factor IIE subunit 1	Homo sapiens	8-10
33765662-3	2021	Herein, in situ synthesis of Fe-doped CrOOH nanosheets on Ni foam (Fe-CrOOH/NF) is designed as electrocatalysts and the OER performance is promoted obviously.	Iron	29-31	neurofascin	Homo sapiens	76-78
33821487-8	2021	It summarises the excess-iron-induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K/AKT, MAPK, p53, AMPK/MFF/DRP1 and Wnt.	Iron	25-29	utrophin	Homo sapiens	158-162
33761877-0	2021	Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer"s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis.	Iron	192-196	presenilin 1	Danio rerio	112-117
33808732-0	2021	Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin.	Iron	0-4	lipocalin 2	Homo sapiens	11-22
33808732-1	2021	Macrophages supply iron to the breast tumor microenvironment by enforced secretion of lipocalin-2 (Lcn-2)-bound iron as well as the increased expression of the iron exporter ferroportin (FPN).	Iron	19-23	lipocalin 2	Homo sapiens	86-97
33808732-1	2021	Macrophages supply iron to the breast tumor microenvironment by enforced secretion of lipocalin-2 (Lcn-2)-bound iron as well as the increased expression of the iron exporter ferroportin (FPN).	Iron	19-23	lipocalin 2	Homo sapiens	99-104
33808732-5	2021	While the total iron amount in wildtype and Lcn-2-/- PyMT tumors showed no difference, we observed that tumor-associated macrophages from Lcn-2-/- compared to wildtype tumors stored more iron.	Iron	187-191	lipocalin 2	Homo sapiens	138-143
33808732-6	2021	In contrast, Lcn-2-/- tumor cells accumulated less iron than their wildtype counterparts, translating into a low migratory and proliferative capacity of Lcn-2-/- tumor cells in a 3D tumor spheroid model in vitro.	Iron	51-55	lipocalin 2	Homo sapiens	13-18
33808732-7	2021	Our data suggest a pivotal role of Lcn-2 in tumor iron-management, affecting tumor growth.	Iron	50-54	lipocalin 2	Homo sapiens	35-40
33799563-5	2021	Iron supplementation improved the iron status in pigs with increased hemoglobin and hematocrit, but did not affect serum levels of iron, zinc, and copper.	Iron	0-4	HGB	Sus scrofa	69-79
33819987-0	2021	DANTE as a primary temperature diagnostic for the NIF iron opacity campaign.	Iron	54-58	DAN domain BMP antagonist family member 5	Homo sapiens	0-5
33232799-1	2021	BACKGROUND: The bone morphogenetic protein 6 (BMP6) is a crucial inducer of hepcidin, the peptide hormone that regulates the iron availability in our body.	Iron	125-129	bone morphogenetic protein 6	Cricetulus griseus	16-44
33232799-1	2021	BACKGROUND: The bone morphogenetic protein 6 (BMP6) is a crucial inducer of hepcidin, the peptide hormone that regulates the iron availability in our body.	Iron	125-129	bone morphogenetic protein 6	Cricetulus griseus	46-50
33777378-1	2021	Background: This study aimed to determine associations among short- and long-acting erythropoiesis stimulating agents (ESAs), changes in serum fibroblast growth factor 23 (FGF23) and biomarkers of iron metabolism.	Iron	197-201	fibroblast growth factor 23	Homo sapiens	172-177
26323600-6	2015	Furthermore, the strain transformed with AFT1-1(up) plasmid, which failed to regulate Aft1 via iron concentration and accumulated Aft1 in the nucleus, showed lower FOB uptake activity.	Iron	95-99	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	41-45
22689674-0	2012	Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses.	Iron	54-58	STEAP family member 3	Mus musculus	0-23
22689674-5	2012	Secondly, we analyzed the regulation of Steap3 expression by inflammatory stimuli and thus, the influence of these stimuli on iron distribution and homeostasis.	Iron	126-130	STEAP family member 3	Mus musculus	40-46
22689674-7	2012	Steap3 deficiency led to impaired iron homeostasis, causing abnormal iron distribution and a decreased availability of cytosolic iron in macrophages.	Iron	34-38	STEAP family member 3	Mus musculus	0-6
22689674-7	2012	Steap3 deficiency led to impaired iron homeostasis, causing abnormal iron distribution and a decreased availability of cytosolic iron in macrophages.	Iron	69-73	STEAP family member 3	Mus musculus	0-6
22689674-11	2012	CONCLUSIONS: Steap3 is important in regulating both iron homeostasis and TLR4-mediated inflammatory responses in macrophages.	Iron	52-56	STEAP family member 3	Mus musculus	13-19
22689674-12	2012	Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4-mediated inflammatory responses in macrophages.	Iron	34-38	STEAP family member 3	Mus musculus	0-6
22689674-13	2012	Following inflammatory stimuli, Steap3 depletion causes dysregulated iron sequestration and distribution.	Iron	69-73	STEAP family member 3	Mus musculus	32-38
22689674-14	2012	Our results provide important insights into the function of Steap3 as a coordinate regulator of both iron homeostasis and innate immunity.	Iron	101-105	STEAP family member 3	Mus musculus	60-66
18211908-2	2008	In this study, we investigated the development of CTS in iron-steel industry workers.	Iron	57-61	transthyretin	Homo sapiens	50-53
34953963-3	2022	In this study, our data suggested that activation of VDR by PAL significantly reduced the iron accumulation in the cortex and hippocampus of APP/PS1 mice through downregulation of Transferrin receptor (TFR) by reducing iron-regulatory protein 2 (IRP2) expression.	Iron	90-94	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	53-56
34953963-5	2022	Taken together, our data suggest that activation of VDR could inhibit the phosphorylations of Tau possibly by repressing the iron accumulation-induced upregulation of GSK3beta activity in the brains of APP/PS1 mice.	Iron	125-129	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	52-55
34873760-7	2022	Furthermore, the ratio of Co to Fe could significantly tune the Co electronic structure of Ni(Co x Fe 1-x )/NF composites (x = 0.25, 0.50 and 0.75) and affect the electrocatalytic activity for OER, in which Ni(Co 0.5 Fe 0.5 )/NF showed the lowest energy barrier for OER rate-determining step (from O* to OOH*).	Iron	32-34	neurofascin	Homo sapiens	108-110
34873760-7	2022	Furthermore, the ratio of Co to Fe could significantly tune the Co electronic structure of Ni(Co x Fe 1-x )/NF composites (x = 0.25, 0.50 and 0.75) and affect the electrocatalytic activity for OER, in which Ni(Co 0.5 Fe 0.5 )/NF showed the lowest energy barrier for OER rate-determining step (from O* to OOH*).	Iron	32-34	neurofascin	Homo sapiens	226-228
34939797-0	2022	Surface Plasmon Resonance Identifies High-Affinity Binding of l-DOPA to Siderocalin/Lipocalin-2 through Iron-Siderophore Action: Implications for Parkinson"s Disease Treatment.	Iron	104-108	lipocalin 2	Homo sapiens	84-95
34939797-4	2022	Catechol siderophore-like compounds are known to bind siderocalin (Scn)/lipocalin-2 to form stable siderophore:Fe:Scn complexes.	Iron	111-113	lipocalin 2	Homo sapiens	72-83
34600924-3	2022	However, the success of implemented Fe(0) PRBs is yet to be rationalized as Fe(0) is a generator of iron oxides (contaminant scavengers) and secondary reducing agents (e.g. Fe(II), Fe3O4, H2, green rust), This communication demonstrates that Fe(0) is not an environmental reducing agent.	Iron	76-81	relaxin 2	Homo sapiens	181-190
34919297-0	2022	Spin states, bonding and magnetism in mixed valence iron(0)-iron(II) complexes.	Iron	52-59	spindlin 1	Homo sapiens	0-4
34919297-3	2022	Mossbauer, magnetism and DFT analysis indicate that the most accurate electronic structure description is LFeII Fe0(CO)2Cp, in which the Fe(CO)2Cp is low-spin iron(0) and acts as an X-type ligand toward the high spin iron(II) of the LFe fragment.	Iron	159-163	spindlin 1	Homo sapiens	154-158
34919297-3	2022	Mossbauer, magnetism and DFT analysis indicate that the most accurate electronic structure description is LFeII Fe0(CO)2Cp, in which the Fe(CO)2Cp is low-spin iron(0) and acts as an X-type ligand toward the high spin iron(II) of the LFe fragment.	Iron	159-163	spindlin 1	Homo sapiens	212-216
34919297-3	2022	Mossbauer, magnetism and DFT analysis indicate that the most accurate electronic structure description is LFeII Fe0(CO)2Cp, in which the Fe(CO)2Cp is low-spin iron(0) and acts as an X-type ligand toward the high spin iron(II) of the LFe fragment.	Iron	217-221	spindlin 1	Homo sapiens	154-158
34919297-3	2022	Mossbauer, magnetism and DFT analysis indicate that the most accurate electronic structure description is LFeII Fe0(CO)2Cp, in which the Fe(CO)2Cp is low-spin iron(0) and acts as an X-type ligand toward the high spin iron(II) of the LFe fragment.	Iron	217-221	spindlin 1	Homo sapiens	212-216
34960080-7	2021	Collectively, these findings demonstrated that the iron-dependent epigenetic mechanism mediated by JARID1B accounted for long-term Bdnf dysregulation by early-life ID.	Iron	51-55	brain-derived neurotrophic factor	Rattus norvegicus	131-135
34812447-0	2021	Chemically robust and readily available quinoline-based PNN iron complexes: application in C-H borylation of arenes.	Iron	60-64	pinin, desmosome associated protein	Homo sapiens	56-59
34812447-4	2021	In this context, our group previously developed a new family of quinoline-based PNN pincer-type ligands for low- to mid-valent iron catalysts.	Iron	127-131	pinin, desmosome associated protein	Homo sapiens	80-83
34812447-5	2021	These chemically robust PNN ligands provide air- and moisture-tolerant iron complexes, which exhibit excellent catalytic performances in the C-H borylation of arenes.	Iron	71-75	pinin, desmosome associated protein	Homo sapiens	24-27
34862195-0	2022	Pharmacological reduction of mitochondrial iron triggers a non-canonical BAX/BAK dependent cell death.	Iron	43-47	BCL2 antagonist/killer 1	Homo sapiens	77-80
34467556-1	2021	Methemoglobinemia is a rare disorder associated with oxidization of divalent ferro-iron of hemoglobin (Hb) to ferri-iron of methemoglobin (MetHb).	Iron	115-120	hemoglobin subunit gamma 2	Homo sapiens	124-137
34488147-2	2021	This case-control study evaluated the associations between 5 common urinary trace elements (copper (Cu), manganese (Mn), Iron (Fe), Selenium (Se), and zinc (Zn)) and the odds for POI.	Iron	121-125	general transcription factor IIE subunit 1	Homo sapiens	127-129
34547407-8	2021	RNA-sequencing analysis in iron overloaded INS-1 cells identified Id1 and Id3 as the top down-regulated genes, while Hmox1 was the top upregulated.	Iron	27-31	heme oxygenase 1	Rattus norvegicus	117-122
34340090-3	2021	Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT.	Iron	101-105	iron-regulated transporter 1	Arabidopsis thaliana	129-133
34839543-0	2022	Root-to-shoot iron partitioning in Arabidopsis requires IRON-REGULATED TRANSPORTER1 (IRT1) protein but not its iron(II) transport function.	Iron	14-18	iron-regulated transporter 1	Arabidopsis thaliana	56-83
34839543-0	2022	Root-to-shoot iron partitioning in Arabidopsis requires IRON-REGULATED TRANSPORTER1 (IRT1) protein but not its iron(II) transport function.	Iron	14-18	iron-regulated transporter 1	Arabidopsis thaliana	85-89
34839543-1	2022	IRON-REGULATED TRANSPORTER1 (IRT1) is the root high-affinity ferrous iron uptake system and indispensable for the completion of the life cycle of Arabidopsis thaliana without vigorous iron (Fe) supplementation.	Iron	190-192	iron-regulated transporter 1	Arabidopsis thaliana	0-27
34839543-1	2022	IRON-REGULATED TRANSPORTER1 (IRT1) is the root high-affinity ferrous iron uptake system and indispensable for the completion of the life cycle of Arabidopsis thaliana without vigorous iron (Fe) supplementation.	Iron	190-192	iron-regulated transporter 1	Arabidopsis thaliana	29-33
34839543-2	2022	Here we provide evidence supporting a second role of IRT1 in root-to-shoot partitioning of Fe.	Iron	91-93	iron-regulated transporter 1	Arabidopsis thaliana	53-57
34839543-3	2022	We show that irt1 mutants over-accumulate Fe in roots, most prominently in the cortex of the differentiation zone in irt1-2, compared to the wild type.	Iron	42-44	iron-regulated transporter 1	Arabidopsis thaliana	13-17
34839543-3	2022	We show that irt1 mutants over-accumulate Fe in roots, most prominently in the cortex of the differentiation zone in irt1-2, compared to the wild type.	Iron	42-44	iron-regulated transporter 1	Arabidopsis thaliana	117-121
34839543-4	2022	Shoots of irt1-2 are severely Fe-deficient according to Fe content and marker transcripts, as expected.	Iron	30-32	iron-regulated transporter 1	Arabidopsis thaliana	10-16
34839543-9	2022	Taken together, these results suggest a function for IRT1 in root-to-shoot Fe partitioning that does not require Fe transport activity of IRT1.	Iron	75-77	iron-regulated transporter 1	Arabidopsis thaliana	53-57
34839543-10	2022	Among the genes of which transcript levels are partially dependent on IRT1, we identify MYB DOMAIN PROTEIN10, MYB DOMAIN PROTEIN72 and NICOTIANAMINE SYNTHASE4 as candidates for effecting IRT1-dependent Fe mobilization in roots.	Iron	202-204	iron-regulated transporter 1	Arabidopsis thaliana	70-74
34839543-10	2022	Among the genes of which transcript levels are partially dependent on IRT1, we identify MYB DOMAIN PROTEIN10, MYB DOMAIN PROTEIN72 and NICOTIANAMINE SYNTHASE4 as candidates for effecting IRT1-dependent Fe mobilization in roots.	Iron	202-204	iron-regulated transporter 1	Arabidopsis thaliana	187-191
34839543-11	2022	Understanding the biological functions of IRT1 will help to improve iron nutrition and the nutritional quality of agricultural crops.	Iron	68-72	iron-regulated transporter 1	Arabidopsis thaliana	42-46
34809535-1	2022	The IRON-REGULATED TRANSPORTER1 (IRT1) is critical for iron uptake in roots, and its exocytosis to the plasma membrane (PM) is regulated by detergent-resistant membranes.	Iron	55-59	iron-regulated transporter 1	Arabidopsis thaliana	4-31
34809535-1	2022	The IRON-REGULATED TRANSPORTER1 (IRT1) is critical for iron uptake in roots, and its exocytosis to the plasma membrane (PM) is regulated by detergent-resistant membranes.	Iron	55-59	iron-regulated transporter 1	Arabidopsis thaliana	33-37
34809535-2	2022	However, studies on IRT1 exocytosis and function in response to iron status are limited.	Iron	64-68	iron-regulated transporter 1	Arabidopsis thaliana	20-24
34811513-7	2021	The decreased iron content was attributed to increased expression of iron exporter ferroportin 1 (FPN1) that was associated with elevated expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in response to Clk1 deficiency both in vivo and in vitro.	Iron	69-73	CDC-like kinase 1	Rattus norvegicus	212-216
34811513-8	2021	Furthermore, we showed that iron played a critical role in mediating Clk1 deficiency-induced alteration in DAT expression, presumably via upstream HIF-1alpha.	Iron	28-32	CDC-like kinase 1	Rattus norvegicus	69-73
34811513-9	2021	Taken together, these data demonstrated that HIF-1alpha-mediated changes in iron homostasis are involved in the Clk1 deficiency-altered METH reward behaviors.	Iron	76-80	CDC-like kinase 1	Rattus norvegicus	112-116
34816444-8	2022	The sensitivity of CHr in detecting absent iron stores (serum ferritin values <= 15 mug/dl) was 66.2% and 74.4%, specificity 92% and 90.6%, PPV 56.7% and 68.7% and NPV 94.5% and 92.8% among FTD and RD cohort, respectively.	Iron	43-47	chromate resistance; sulfate transport	Homo sapiens	19-22
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	43-47	ferritin light chain	Homo sapiens	95-98
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	129-133	ferritin light chain	Homo sapiens	95-98
34775773-17	2022	DISCUSSION: Phosphate binders can effectively reduce serum intact FGF23 levels in CKD patients, and iron-based phosphate binders have better effect on reducing serum intact FGF23 levels than other phosphate binders.	Iron	100-104	fibroblast growth factor 23	Homo sapiens	173-178
34311475-0	2021	Hepcidin inhibition improves iron homeostasis in ferrous sulfate and LPS treatment model in mice.	Iron	29-33	hepcidin antimicrobial peptide	Mus musculus	0-8
34311475-1	2021	BACKGROUND: Hepcidin, a liver-derived peptide, regulates the absorption, distribution, and circulation of iron in the body.	Iron	106-110	hepcidin antimicrobial peptide	Mus musculus	12-20
34593305-8	2021	In this review, we examine the potential properties of GDF15 as an emerging modulator of immunity in COVID-19 in association with iron metabolism.	Iron	130-134	growth differentiation factor 15	Homo sapiens	55-60
34765600-8	2021	In lung adenocarcinoma (LUAD) tissues, lipid peroxidation and labile iron decreased, while YAP, TFCP2 and FTL increased compared to their adjacent normal tissues, and the lipid peroxidation marker 4-hydroxynonenal (4-HNE) was negatively correlated with the level of FTL or the degree of LUAD malignancy, but LUAD tissues with lower levels of 4-HNE showed a higher sensitivity to ferroptosis.	Iron	69-73	ferritin light chain	Homo sapiens	266-269
34570976-7	2021	More interestingly, we notice reversible spin textures by switching the FE polarization in CsPbF3 perovskite, making it potent for perovskite-based spintronic applications.	Iron	72-74	spindlin 1	Homo sapiens	41-45
34854600-7	2021	Serum FGF23 level was increased confirming the diagnosis of FGF23 mediated hypophosphatemicosteomalacia induced by intravenous iron suppletion.	Iron	127-131	fibroblast growth factor 23	Homo sapiens	6-11
34854600-7	2021	Serum FGF23 level was increased confirming the diagnosis of FGF23 mediated hypophosphatemicosteomalacia induced by intravenous iron suppletion.	Iron	127-131	fibroblast growth factor 23	Homo sapiens	60-65
34675764-1	2021	Iron regulatory protein 2 (IRP2) deficiency in mice and humans causes microcytic anemia and neurodegeneration due to functional cellular iron depletion.	Iron	137-141	iron responsive element binding protein 2	Mus musculus	0-25
34675764-1	2021	Iron regulatory protein 2 (IRP2) deficiency in mice and humans causes microcytic anemia and neurodegeneration due to functional cellular iron depletion.	Iron	137-141	iron responsive element binding protein 2	Mus musculus	27-31
34547208-12	2021	The Bronsted basicities of L1-L3 are very sensitive to the linkage isomerism of their triazolyl donors, which explains why their iron complex spin states show more variation than the better-known iron(II)/2,6-dipyrazolylpyridine system.	Iron	129-133	spindlin 1	Homo sapiens	142-146
34227899-4	2021	Here we found a similar tendency for Fe under excess Ni; however, the expression of iron-regulated transporter 1 (IRT1), which encodes the primary Fe uptake transporter and causes excess Ni uptake in Arabidopsis thaliana, was higher in N. japonica.	Iron	37-39	iron-regulated transporter 1	Arabidopsis thaliana	84-112
34227899-4	2021	Here we found a similar tendency for Fe under excess Ni; however, the expression of iron-regulated transporter 1 (IRT1), which encodes the primary Fe uptake transporter and causes excess Ni uptake in Arabidopsis thaliana, was higher in N. japonica.	Iron	37-39	iron-regulated transporter 1	Arabidopsis thaliana	114-118
34227899-4	2021	Here we found a similar tendency for Fe under excess Ni; however, the expression of iron-regulated transporter 1 (IRT1), which encodes the primary Fe uptake transporter and causes excess Ni uptake in Arabidopsis thaliana, was higher in N. japonica.	Iron	147-149	iron-regulated transporter 1	Arabidopsis thaliana	84-112
34227899-4	2021	Here we found a similar tendency for Fe under excess Ni; however, the expression of iron-regulated transporter 1 (IRT1), which encodes the primary Fe uptake transporter and causes excess Ni uptake in Arabidopsis thaliana, was higher in N. japonica.	Iron	147-149	iron-regulated transporter 1	Arabidopsis thaliana	114-118
34473424-4	2021	Theoretical modeling suggests that the NRR preferably takes place on FeN4 instead of MoN4 , and the transition of Fe spin state significantly lowers the energy barrier of the potential determining step, which is conducive to the first hydrogenation of N2 .	Iron	114-116	spindlin 1	Homo sapiens	117-121
34504604-5	2021	The present review discusses the associations between FGF23, iron, EPO and hypoxia-inducible factors (HIFs), and their impact on FGF23 bioactivity, focusing on recent studies.	Iron	61-65	fibroblast growth factor 23	Homo sapiens	129-134
34464637-7	2021	The protective effect of MAME against iron-overload-induced apoptosis was confirmed by upregulation of protein levels of Bax, Caspase-3, and PARP.	Iron	38-42	BCL2-associated X protein	Mus musculus	121-124
34464637-7	2021	The protective effect of MAME against iron-overload-induced apoptosis was confirmed by upregulation of protein levels of Bax, Caspase-3, and PARP.	Iron	38-42	caspase 3	Mus musculus	126-135
34464637-7	2021	The protective effect of MAME against iron-overload-induced apoptosis was confirmed by upregulation of protein levels of Bax, Caspase-3, and PARP.	Iron	38-42	poly (ADP-ribose) polymerase family, member 1	Mus musculus	141-145
34284261-8	2021	One factor, comprised of vitamin E, lysine, DHA omega-3 and LA omega-6 PUFA, representing food groups such as nuts, healthy oils and fish, moderated the effects of age on both brain iron concentration and working memory performance, suggesting that these nutrients may slow the rate of brain iron accumulation and working memory declines in aging.	Iron	182-186	pumilio RNA binding family member 3	Homo sapiens	71-75
34284261-8	2021	One factor, comprised of vitamin E, lysine, DHA omega-3 and LA omega-6 PUFA, representing food groups such as nuts, healthy oils and fish, moderated the effects of age on both brain iron concentration and working memory performance, suggesting that these nutrients may slow the rate of brain iron accumulation and working memory declines in aging.	Iron	292-296	pumilio RNA binding family member 3	Homo sapiens	71-75
34529421-0	2021	Accessing Photoredox Transformations with an Iron(III) Photosensitizer and Green Light.	Iron	45-49	general transcription factor IIE subunit 1	Homo sapiens	50-53
34529421-1	2021	Efficient excited-state electron transfer between an iron(III) photosensitizer and organic electron donors was realized with green light irradiation.	Iron	53-57	general transcription factor IIE subunit 1	Homo sapiens	58-61
34560744-5	2021	The contamination of the implant and bone tissue with aluminum (Al), iron (Fe), and mercury (Hg) potentially had an influence on the integration of bone tissue and the health of peri-implant tissue.	Iron	69-73	general transcription factor IIE subunit 1	Homo sapiens	75-77
34547719-8	2021	Subsequently, excessive iron led to oxidative stress and impaired mitochondrial function that further led to glucose metabolism disorder and reduced ATP production by regulating the expression of key enzyme genes or proteins including G6Pase, Pck1, and Cs.	Iron	24-28	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	243-247
34551530-10	2021	The FPA based on the linearized MR-DSRG theory with one- and two-body operators and up to a quintuple-zeta basis set predicts the spin splittings of (Fe(H2O)6)2+ and (Fe(NH3)6)2+ to be -35.7 and -17.1 kcal mol-1, respectively, showing good agreement with the results of local CC theory with singles, doubles, and perturbative triples.	Iron	150-152	spindlin 1	Homo sapiens	130-134
34292639-2	2021	At the same time, the Fe II (Bn3MC) 2+ ( 1 ) precursor to 2 - syn is re-generated in a 1:2 molar ratio relative to 3 , accounting for the first time for all the electrons involved and all the Fe species derived from 2 - syn as shown in the following balanced equation.	Iron	192-194	synemin	Homo sapiens	62-65
34292639-2	2021	At the same time, the Fe II (Bn3MC) 2+ ( 1 ) precursor to 2 - syn is re-generated in a 1:2 molar ratio relative to 3 , accounting for the first time for all the electrons involved and all the Fe species derived from 2 - syn as shown in the following balanced equation.	Iron	192-194	synemin	Homo sapiens	220-223
34325073-5	2021	Experimental studies indicate that Lcn2 contributes to various neuropathophysiological processes of age-related CNS diseases, including exacerbated neuroinflammation, cell death and iron dysregulation, which may negatively impact cognitive function.	Iron	182-186	lipocalin 2	Homo sapiens	35-39
34287090-4	2021	We recently reported that peroxisome proliferator activated receptor alpha (PPARalpha) agonist, fenofibrate prevents iron induced oxidative stress and beta-catenin signaling by chelating the iron.	Iron	191-195	catenin (cadherin associated protein), beta 1	Mus musculus	151-163
34287090-7	2021	In-vitro and in-vivo iron treatment resulted in the downregulation of PPARalpha, Sirt3, active beta-catenin and its downstream target gene c-Myc in the mouse liver.	Iron	21-25	catenin (cadherin associated protein), beta 1	Mus musculus	95-107
34287090-8	2021	Pharmacological activation of Sirt3, both invitro and in vivo, by Honokiol (HK), a known activator of Sirt3, abrogated the inhibitory effect of iron overload on active beta-catenin expression and prevented the iron induced upregulation of alphaSMA and TGFbeta expression.	Iron	144-148	catenin (cadherin associated protein), beta 1	Mus musculus	168-180
34287090-10	2021	In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis.	Iron	26-30	catenin (cadherin associated protein), beta 1	Mus musculus	182-194
34287090-10	2021	In addition, treatment of iron overload mice with PPARalpha agonist fenofibrate reduced hepatic iron accumulation and prevented iron induced downregulation of liver Sirt3 and active beta-catenin, mitigating the progression of fibrosis.	Iron	128-132	catenin (cadherin associated protein), beta 1	Mus musculus	182-194
34287090-11	2021	Thus, our results establish a novel link between hepatic iron and PPARalpha, Sirt3 and beta-catenin signaling.	Iron	57-61	catenin (cadherin associated protein), beta 1	Mus musculus	87-99
34384050-3	2021	Our results suggest that the resonance mode in iron-based superconductors becomes isotropic when the influence of spin-orbit coupling and magnetic/nematic order is minimized, similar to those observed in cuprate superconductors.	Iron	47-51	spindlin 1	Homo sapiens	114-118
34224364-5	2021	We further found that VLX600 and other iron chelators disrupt HR, in part, by inhibiting iron-dependent histone lysine demethylases (KDM) family members, thus blocking recruitment of HR repair proteins, including RAD51, to double-strand DNA breaks.	Iron	39-43	RAD51 recombinase	Homo sapiens	213-218
34415720-8	2021	In the in vivo experiment, we subcutaneously implanted U251 MG cells in nude mice as a xenograft model to demonstrate the photothermal activity of MCP-1/GNR@MIL-100(Fe).	Iron	165-167	chemokine (C-C motif) ligand 2	Mus musculus	147-152
34415720-10	2021	MCP-1/GNR@MIL-100(Fe) combined with the laser treatment showed an excellent antitumor efficacy from the histology of tumor tissues, survival rates, and bioluminescence imaging.	Iron	18-20	chemokine (C-C motif) ligand 2	Mus musculus	0-5
34353025-3	2021	Here, we proposed a design concept, i.e., integrating phase boundary and defect engineering, to resolve the above challenges, based on a concrete example of Fe-modified 0.51Pb(Hf0.35Ti0.65)O3-0.49Pb(Nb2/3Ni1/3)O3 (0.51PHT-0.49PNN) ceramics.	Iron	157-159	pinin, desmosome associated protein	Homo sapiens	226-229
34439901-4	2021	Moreover, within the developing brain, iron is critical to hippocampal maturation and the differentiation of parvalbumin-expressing neurons, whose soma and dendrites are surrounded by perineuronal nets (PNNs).	Iron	39-43	parvalbumin	Homo sapiens	109-120
34293724-0	2021	Spin-to-charge conversion and interface-induced spin Hall magnetoresistance in yttrium iron garnet/metallic bilayers.	Iron	87-91	spindlin 1	Homo sapiens	0-4
34293724-0	2021	Spin-to-charge conversion and interface-induced spin Hall magnetoresistance in yttrium iron garnet/metallic bilayers.	Iron	87-91	spindlin 1	Homo sapiens	48-52
34293724-1	2021	We report the investigation of spin-to-charge current interconversion process in hybrid structures of yttrium iron garnet (YIG)/metallic bilayers by means of two different experimental techniques: spin pumping effect (SPE) and spin Hall magnetoresistance (SMR).	Iron	110-114	spindlin 1	Homo sapiens	31-35
34293724-1	2021	We report the investigation of spin-to-charge current interconversion process in hybrid structures of yttrium iron garnet (YIG)/metallic bilayers by means of two different experimental techniques: spin pumping effect (SPE) and spin Hall magnetoresistance (SMR).	Iron	110-114	spindlin 1	Homo sapiens	197-201
34383040-0	2021	Hepatocyte neogenin, another key actor in iron homeostasis.	Iron	42-46	neogenin 1	Homo sapiens	11-19
34338530-1	2021	In photosystem I, two electron-transfer pathways via quinones (A1A and A1B) are merged at the iron-sulfur Fe4S4 cluster FX into a single pathway toward the other two Fe4S4 clusters FA and FB.	Iron	94-98	alpha-1-B glycoprotein	Homo sapiens	71-74
34338530-4	2021	FX has two independent electron acceptor Fe sites for A- and B-branch electron transfers, depending on the Asp-B575 protonation state, which causes the A1A-to-FX electron transfer to be uphill and the A1B-to-FX electron transfer to be downhill.	Iron	41-43	alpha-1-B glycoprotein	Homo sapiens	201-204
34292703-9	2021	Ground-state bleaching of the Fe(III) absorption band observed through pulse radiolysis indicates that iron may react with Cl2 - radicals to form an oxidized transient species under irradiation.	Iron	103-107	endogenous retrovirus group W member 5	Homo sapiens	123-126
34273604-12	2021	The variable importance in the projection values (VIP > 1) of OPLS-DA model and SNK test (p < 0.05) revealed Fe, Cu, Cr and Se as elemental biomarkers.	Iron	109-111	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	50-57
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	80-82	S100 calcium binding protein A9	Homo sapiens	191-194
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	144-146	S100 calcium binding protein A9	Homo sapiens	91-94
34171644-3	2021	Herein, a novel electrocatalyst of Fe-doped CoP nanotubes array on nickel foam (Fe-CoP NTs/NiF) is prepared through a simple ultrasonication of Fe-doped CoP nanowires hydrothermally grown on NiF.	Iron	144-146	S100 calcium binding protein A9	Homo sapiens	191-194
34362147-12	2021	We propose that this correlation may be related to increased hematopoietic stress, increased consumption of nitric oxide (NO) by hemolysis, and the inhibitory effects of iron supplements on osteogenesis through the receptor activator of nuclear factor kappaB ligand (RANKL)/Osteoprotegerin pathway and the Runt-related transcription factor 2 (RUNX2) factor.	Iron	170-174	TNF superfamily member 11	Homo sapiens	215-265
34362147-12	2021	We propose that this correlation may be related to increased hematopoietic stress, increased consumption of nitric oxide (NO) by hemolysis, and the inhibitory effects of iron supplements on osteogenesis through the receptor activator of nuclear factor kappaB ligand (RANKL)/Osteoprotegerin pathway and the Runt-related transcription factor 2 (RUNX2) factor.	Iron	170-174	TNF superfamily member 11	Homo sapiens	267-272
34394837-9	2021	In vitro, PQ significantly caused the iron accumulation in cytoplasm and mitochondria through ferritinophagy pathway induced by NCOA4.	Iron	38-42	nuclear receptor coactivator 4	Homo sapiens	128-133
34368018-1	2021	Introduction: Hepcidin is the systemic master regulator of iron metabolism as it degrades the cellular iron exporter ferroportin.	Iron	59-63	hepcidin antimicrobial peptide	Mus musculus	14-22
34368018-1	2021	Introduction: Hepcidin is the systemic master regulator of iron metabolism as it degrades the cellular iron exporter ferroportin.	Iron	103-107	hepcidin antimicrobial peptide	Mus musculus	14-22
34368018-2	2021	In bacterial infections, hepcidin is upregulated to limit circulating iron for pathogens, thereby increasing iron retention in macrophages.	Iron	70-74	hepcidin antimicrobial peptide	Mus musculus	25-33
34368018-2	2021	In bacterial infections, hepcidin is upregulated to limit circulating iron for pathogens, thereby increasing iron retention in macrophages.	Iron	109-113	hepcidin antimicrobial peptide	Mus musculus	25-33
34359572-6	2021	This review summarizes the current knowledge on the mechanism behind the observed impact of NUPR1 on mitochondrial function, energy metabolism, iron metabolism, and the antioxidant system.	Iron	144-148	nuclear protein 1, transcriptional regulator	Homo sapiens	92-97
34218351-5	2022	A newly synthesized combinational iron chelating PpIX prodrug (AP2-18) has been assessed experimentally in cultured primary human cells of bladder and dermatological origin, as an alternative photosensitizing agent to ALA or its methyl or hexyl esters (MAL and HAL respectively) for photodetection/PDT.	Iron	34-38	transcription factor AP-2 alpha	Homo sapiens	63-69
34218351-9	2022	AP2-18 iron chelation should continue to be investigated for the enhancement of dermatological PpIX-PDT applications but not bladder photodetection/PDT.	Iron	7-11	transcription factor AP-2 alpha	Homo sapiens	0-6
34356833-13	2021	Renal tissue showed decreased erythropoietin and HIF-2alpha mRNA levels, while an increase in the iron metabolism regulator hepcidin was observed.	Iron	98-102	hepcidin antimicrobial peptide	Mus musculus	124-132
34281233-6	2021	Iron chelator-induced apoptosis was due to the activation of the MAPK signaling pathway, with increased phosphorylation levels of JNK, p38 and ERK, and ROS generation; in this process, the expression of C-caspase-3 and C-PARP increased.	Iron	0-4	mitogen-activated protein kinase 8	Mus musculus	130-133
34281233-6	2021	Iron chelator-induced apoptosis was due to the activation of the MAPK signaling pathway, with increased phosphorylation levels of JNK, p38 and ERK, and ROS generation; in this process, the expression of C-caspase-3 and C-PARP increased.	Iron	0-4	poly (ADP-ribose) polymerase family, member 1	Mus musculus	221-225
34276623-1	2021	Iron (Fe) is the fourth most abundant element in the Earth"s crust where ferrous Fe (Fe(II)) and ferric Fe (Fe(III)) can be used by archaea for energy conservation.	Iron	0-4	general transcription factor IIE subunit 1	Homo sapiens	108-115
34276623-1	2021	Iron (Fe) is the fourth most abundant element in the Earth"s crust where ferrous Fe (Fe(II)) and ferric Fe (Fe(III)) can be used by archaea for energy conservation.	Iron	6-8	general transcription factor IIE subunit 1	Homo sapiens	108-115
34276623-3	2021	As no Fe is incorporated into the archaeal cells, these redox reactions are referred to as dissimilatory Fe(III) reduction and Fe(II) oxidation, respectively.	Iron	6-8	general transcription factor IIE subunit 1	Homo sapiens	105-112
34276623-4	2021	Dissimilatory Fe(III)-reducing archaea (FeRA) and Fe(II)-oxidizing archaea (FeOA) are widespread on Earth where they play crucial roles in biogeochemical cycling of not only Fe, but also carbon and sulfur.	Iron	174-176	general transcription factor IIE subunit 1	Homo sapiens	14-21
33715691-0	2021	The Effects of Fe Film Thickness and the H2 Annealing Time on the Spin-Capability of Carbon Nanotube Forest with Chemical Vapor Deposition Method.	Iron	15-17	spindlin 1	Homo sapiens	66-70
33715691-1	2021	The effects of as-deposited iron (Fe) film thickness and the hydrogen (H2) annealing time on the spin-capability of carbon nanotube (CNT) forest have been studied.	Iron	28-32	spindlin 1	Homo sapiens	97-101
33715691-1	2021	The effects of as-deposited iron (Fe) film thickness and the hydrogen (H2) annealing time on the spin-capability of carbon nanotube (CNT) forest have been studied.	Iron	34-36	spindlin 1	Homo sapiens	97-101
33715691-2	2021	Both, the as-deposited Fe film thickness and the H2 annealing time significantly changed the morphology of Fe nanoparticles (NPs) after annealing process during the synthesis step of spin-capable carbon nanotube (SCNT) forest.	Iron	23-25	spindlin 1	Homo sapiens	183-187
33715691-2	2021	Both, the as-deposited Fe film thickness and the H2 annealing time significantly changed the morphology of Fe nanoparticles (NPs) after annealing process during the synthesis step of spin-capable carbon nanotube (SCNT) forest.	Iron	107-109	spindlin 1	Homo sapiens	183-187
33715691-4	2021	In conclusion, the spin-capability of CNT forest can be achieved by controlling the initial Fe film thickness and/or the H2 annealing time.	Iron	92-94	spindlin 1	Homo sapiens	19-23
34238411-3	2021	Results The weight gain percentages of mice in the negative control, low-, medium-, and high-dose iron groups were 25.47%, 25.22%, 24.74%, and 21.36%, respectively, which was significantly lower in the high-dose group than in the negative control(F=17.235, P=0.027), low-dose(F=15.206, P=0.031), and medium-dose(F=11.061, P=0.036)groups.Liver had the highest iron content, followed by spleen, kidney, and small intestine.The iron content in heart and lung tissues of the low-dose group had no significant difference compared with those of the negative control group(F=19.023, P=0.715;F=23.193, P=0.902).Serum iron and ferritin in the iron-overloaded mice increased in a dose-dependent manner, while transferrin and transferrin receptor had no significant changes.HE and Prussian blue staining showed that the iron-overloaded mice had different degrees of iron deposition in tissues and high-dose iron caused liver and kidney damage.The lung(F=23.227, P=0.017), spleen(F=19.023, P=0.021), and liver(F=17.392, P=0.009)of the iron-overloaded mice with TB had a significantly shorter time of bacterial culture than those of the TB-infected mice without iron overload.The lung(F=21.012, P=0.007), spleen(F=20.173, P=0.002), and liver(F=19.091, P=0.005)of the iron-overloaded mice with TB had significantly higher bacterial loads than those of the TB-infected mice without iron overload.	Iron	98-102	transferrin	Mus musculus	699-710
34209797-0	2021	Iron Released after Cryo-Thermal Therapy Induced M1 Macrophage Polarization, Promoting the Differentiation of CD4+ T Cells into CTLs.	Iron	0-4	CD4 antigen	Mus musculus	110-113
34209797-9	2021	In addition, iron-induced M1 macrophages and mature DCs promoted the differentiation of CD4+ T cells into the CD4 cytolytic T lymphocytes (CTL) subset and inhibited differentiation into Th2 and Th17 cells.	Iron	13-17	CD4 antigen	Mus musculus	88-91
34209797-9	2021	In addition, iron-induced M1 macrophages and mature DCs promoted the differentiation of CD4+ T cells into the CD4 cytolytic T lymphocytes (CTL) subset and inhibited differentiation into Th2 and Th17 cells.	Iron	13-17	CD4 antigen	Mus musculus	110-113
34183746-1	2021	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin (FPN1).	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	73-81
34183746-1	2021	Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin (FPN1).	Iron	146-150	hepcidin antimicrobial peptide	Mus musculus	73-81
34248600-0	2021	Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum.	Iron	20-24	lipocalin 2	Homo sapiens	41-52
34248600-4	2021	Lipocalin 2 (LCN2), an iron-related protein, has been suggested as a potential marker for mild cognitive impairment (MCI) and AD.	Iron	23-27	lipocalin 2	Homo sapiens	0-11
34248600-4	2021	Lipocalin 2 (LCN2), an iron-related protein, has been suggested as a potential marker for mild cognitive impairment (MCI) and AD.	Iron	23-27	lipocalin 2	Homo sapiens	13-17
34161397-5	2021	Herein, we utilized human Huh7 hepatoma cells and primary murine hepatocytes to assess the effects of iron perturbations on signaling to hepcidin.	Iron	102-106	hepcidin antimicrobial peptide	Mus musculus	137-145
34161397-6	2021	Iron chelation appeared to slightly impair signaling to hepcidin.	Iron	0-4	hepcidin antimicrobial peptide	Mus musculus	56-64
34108442-4	2021	To understand how bone deficits develop in Tg2576 mice, we used a multiplex antibody array to screen for serum proteins that are altered in Tg2576 mice and identified hepcidin, a master regulator of iron homeostasis.	Iron	199-203	hepcidin antimicrobial peptide	Mus musculus	167-175
34108442-7	2021	Further cell studies suggested that hepcidin increased OC precursor proliferation and differentiation by downregulating ferroportin (FPN) expression and increasing intracellular iron levels.	Iron	178-182	hepcidin antimicrobial peptide	Mus musculus	36-44
34108442-9	2021	Together, these results suggest that increased hepcidin expression in hepatocytes and OB lineage cells in Tg2576 mice contributes to enhanced osteoclastogenesis and trabecular bone loss, identifying the hepcidin-FPN-iron axis as a potential therapeutic target to prevent AD-associated bone loss.	Iron	216-220	hepcidin antimicrobial peptide	Mus musculus	47-55
34108442-9	2021	Together, these results suggest that increased hepcidin expression in hepatocytes and OB lineage cells in Tg2576 mice contributes to enhanced osteoclastogenesis and trabecular bone loss, identifying the hepcidin-FPN-iron axis as a potential therapeutic target to prevent AD-associated bone loss.	Iron	216-220	hepcidin antimicrobial peptide	Mus musculus	203-211
34093616-3	2021	The reduction-based mechanism has prime importance in the Fe uptake of chloroplasts operated by Ferric Reductase Oxidase 7 (FRO7) in the inner chloroplast envelope membrane.	Iron	58-60	ferric reduction oxidase 7	Arabidopsis thaliana	124-128
34094919-1	2021	Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to cellular iron homeostasis by favouring its export.	Iron	97-101	hephaestin	Homo sapiens	0-10
34094919-1	2021	Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to cellular iron homeostasis by favouring its export.	Iron	97-101	hephaestin	Homo sapiens	12-16
34094919-2	2021	Down-regulation of HEPH expression, possibly by stimulating cell proliferation due to an increase in iron availability, has shown to correlate with poor survival in breast cancer.	Iron	101-105	hephaestin	Homo sapiens	19-23
34094919-3	2021	The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tension present, however, HEPH distribution in lung cancer and its influence on prognosis have not been investigated yet.	Iron	38-42	hephaestin	Homo sapiens	117-121
34069743-0	2021	Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis.	Iron	0-4	lipocalin 2	Homo sapiens	11-22
34069743-1	2021	While the importance of the iron-load of lipocalin-2 (Lcn-2) in promoting tumor progression is widely appreciated, underlying molecular mechanisms largely remain elusive.	Iron	28-32	lipocalin 2	Homo sapiens	41-52
34069743-1	2021	While the importance of the iron-load of lipocalin-2 (Lcn-2) in promoting tumor progression is widely appreciated, underlying molecular mechanisms largely remain elusive.	Iron	28-32	lipocalin 2	Homo sapiens	54-59
34069743-2	2021	Considering its role as an iron-transporter, we aimed at clarifying iron-loaded, holo-Lcn-2 (hLcn-2)-dependent signaling pathways in affecting renal cancer cell viability.	Iron	68-72	lipocalin 2	Homo sapiens	93-99
34069743-10	2021	Our study provides mechanistic details to better understand tumor pro-survival pathways initiated by iron-loaded Lcn-2.	Iron	101-105	lipocalin 2	Homo sapiens	113-118
34218583-11	2021	Patients of ID/IDE group absorbed iron more slowly than patients of IDA group.	Iron	34-38	insulin degrading enzyme	Homo sapiens	15-18
34164054-1	2021	We report on the first isolation and structural characterization of an iron phosphinoimino-borane complex Cp*Fe(eta2-H2B(double bond, length as m-dash)NC6H4PPh2) by dehydrogenation of iron amido-borane precursor Cp*Fe(eta1-H3B-NHC6H4PPh2).	Iron	109-111	H3 clustered histone 4	Homo sapiens	223-226
34370287-1	2021	Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process known as ferritinophagy.	Iron	137-141	nuclear receptor coactivator 4	Homo sapiens	0-30
34370287-1	2021	Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process known as ferritinophagy.	Iron	137-141	nuclear receptor coactivator 4	Homo sapiens	32-37
34370287-2	2021	NCOA4-mediated ferritinophagy is required to maintain intracellular and systemic iron homeostasis and thereby iron-dependent physiologic processes such as erythropoiesis.	Iron	81-85	nuclear receptor coactivator 4	Homo sapiens	0-5
34370287-2	2021	NCOA4-mediated ferritinophagy is required to maintain intracellular and systemic iron homeostasis and thereby iron-dependent physiologic processes such as erythropoiesis.	Iron	110-114	nuclear receptor coactivator 4	Homo sapiens	0-5
34370287-3	2021	Given this role of ferritinophagy in regulating iron homeostasis, modulating NCOA4-mediated ferritinophagic flux alters sensitivity to ferroptosis, a non-apoptotic iron-dependent form of cell death triggered by peroxidation of polyunsaturated fatty acids (PUFAs).	Iron	48-52	nuclear receptor coactivator 4	Homo sapiens	77-82
34370287-3	2021	Given this role of ferritinophagy in regulating iron homeostasis, modulating NCOA4-mediated ferritinophagic flux alters sensitivity to ferroptosis, a non-apoptotic iron-dependent form of cell death triggered by peroxidation of polyunsaturated fatty acids (PUFAs).	Iron	164-168	nuclear receptor coactivator 4	Homo sapiens	77-82
34125005-5	2021	Fe, followed by Al, had the highest average metallic element concentrations in particles of various sizes (PM18, PM10, PM2.5, PM1 and PM<1(0.3)); Cd had the lowest.	Iron	0-2	transmembrane protein 11	Homo sapiens	126-129
35487006-2	2022	Here, we rationally designed a novel and vigorous chitosan grafted Fe-doped-carbon dots (CS@Fe/CDs) as an efficient artificial nanozyme to combat rigid bacterial biofilms through the selective activation of Fenton-like reaction-triggered peroxidase-like catalytic activity and the synergistic antibacterial activity of CS.	Iron	92-94	AT695_RS02070	Staphylococcus aureus	238-248
35487006-3	2022	On the one hand, the peroxidase-like catalytic activity made CS@Fe/CDs catalyze H2O2 for producing hydroxyl radicals ( OH), resulting in efficient cleavage of extracellular DNA (eDNA).	Iron	64-66	AT695_RS02070	Staphylococcus aureus	21-31
35597263-2	2022	In mammals, iron is predominantly bound to protein carriers such as transferrin and ferritin and the strategies adopted by the infected host to restrict its uptake by pathogens are still not elucidated.	Iron	12-16	transferrin	Mus musculus	68-79
35367494-1	2022	Atmospheric deposition is a key mode of iron (Fe) input to ocean regions where low concentrations of this micronutrient limit marine primary production.	Iron	40-44	general transcription factor IIE subunit 1	Homo sapiens	46-48
35367494-3	2022	Iron isotope (54Fe, 56Fe, 57Fe, 58Fe) analysis is a potential tool for tracing natural and anthropogenic Fe inputs to the ocean.	Iron	0-4	general transcription factor IIE subunit 1	Homo sapiens	105-107
35525316-8	2022	The toxicity of GH on zebrafish embryonic development and cardiovascular may due to large amounts of downregulated genes involved in metabolic pathways and DEGs related to "Iron ion binding" and "Heme binding" functions.	Iron	173-177	delta(4)-desaturase, sphingolipid 1	Danio rerio	156-160
35394650-1	2022	Glutathione (GSH) is known to regulate iron (Fe) deficiency response in plants but its involvement in modulating subcellular Fe homeostasis remains elusive.	Iron	39-43	general transcription factor IIE subunit 1	Homo sapiens	45-47
35593209-10	2022	Our study shows that even a far-upstream component of the iron regulatory machinery (Grx3/4) can be bypassed, and cellular networks involving RIM101 pH sensing, cAMP signaling, mTOR nutritional signaling, or bromodomain acetylation, may confer the bypassing activities.	Iron	58-62	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	85-91
35325739-0	2022	Highly enhanced heterogeneous photo-Fenton process for tetracycline degradation by Fe/SCN Fenton-like catalyst.	Iron	83-85	sorcin	Homo sapiens	86-89
35325739-1	2022	To suppress the electron-hole recombination and enhance the electron transfer on carbon nitride, an Fe-doped porous carbon nitride catalyst (Fe/SCN) was synthesized via supramolecular self-assembly method and applied in heterogeneous Fenton activation for efficient tetracycline (TC) degradation.	Iron	141-143	sorcin	Homo sapiens	144-147
35325739-5	2022	Three possible pathways of TC degradation were proposed, and the biological inhibition test revealed the potential of Fe/SCN/H2O2 system to reduce environmental risks caused by TC.	Iron	118-120	sorcin	Homo sapiens	121-124
35217035-5	2022	It was concluded that two selected Pseudomonas strains have NAFO functionality by addition of iron as iron reduction-oxidation pair in the arid soil, further potentially fixing NH4+ while As(III) can be effectively remediated through the FeOB participation in forms of adsorption and co-precipitation of Fe(OH)3 through an oxidation of Fe(II) process.	Iron	94-98	general transcription factor IIE subunit 1	Homo sapiens	304-311
35217035-5	2022	It was concluded that two selected Pseudomonas strains have NAFO functionality by addition of iron as iron reduction-oxidation pair in the arid soil, further potentially fixing NH4+ while As(III) can be effectively remediated through the FeOB participation in forms of adsorption and co-precipitation of Fe(OH)3 through an oxidation of Fe(II) process.	Iron	102-106	general transcription factor IIE subunit 1	Homo sapiens	304-311
35445268-4	2022	This compensatory response through Fe-starvation-triggered organ-to-organ communication includes the upregulation of Iron-regulated transporter 1 (IRT1) gene expression on the iron-sufficient side of the root, however, the molecular basis underlying this long-distance signaling remain unclear.	Iron	35-37	iron-regulated transporter 1	Arabidopsis thaliana	117-145
35445268-4	2022	This compensatory response through Fe-starvation-triggered organ-to-organ communication includes the upregulation of Iron-regulated transporter 1 (IRT1) gene expression on the iron-sufficient side of the root, however, the molecular basis underlying this long-distance signaling remain unclear.	Iron	35-37	iron-regulated transporter 1	Arabidopsis thaliana	147-151
35445268-4	2022	This compensatory response through Fe-starvation-triggered organ-to-organ communication includes the upregulation of Iron-regulated transporter 1 (IRT1) gene expression on the iron-sufficient side of the root, however, the molecular basis underlying this long-distance signaling remain unclear.	Iron	176-180	iron-regulated transporter 1	Arabidopsis thaliana	117-145
35445268-4	2022	This compensatory response through Fe-starvation-triggered organ-to-organ communication includes the upregulation of Iron-regulated transporter 1 (IRT1) gene expression on the iron-sufficient side of the root, however, the molecular basis underlying this long-distance signaling remain unclear.	Iron	176-180	iron-regulated transporter 1	Arabidopsis thaliana	147-151
35445268-6	2022	Genome-wide expression analysis showed that localized iron depletion in roots upregulated several genes involved in iron uptake and signaling, such as IRT1, in a distant part of the root exposed to iron-sufficient conditions.	Iron	54-58	iron-regulated transporter 1	Arabidopsis thaliana	151-155
35445268-6	2022	Genome-wide expression analysis showed that localized iron depletion in roots upregulated several genes involved in iron uptake and signaling, such as IRT1, in a distant part of the root exposed to iron-sufficient conditions.	Iron	116-120	iron-regulated transporter 1	Arabidopsis thaliana	151-155
35445268-6	2022	Genome-wide expression analysis showed that localized iron depletion in roots upregulated several genes involved in iron uptake and signaling, such as IRT1, in a distant part of the root exposed to iron-sufficient conditions.	Iron	198-202	iron-regulated transporter 1	Arabidopsis thaliana	151-155
35445268-8	2022	Loss of IRON MAN /FE-UPTAKE-INDUCING PEPTIDE (IMA/FEP) leads to the disruption of compensatory upregulation of IRT1 in the root surrounded by sufficient iron.	Iron	18-20	iron-regulated transporter 1	Arabidopsis thaliana	111-115
35147903-6	2022	However, Cp deficiency affected the expression of many iron metabolism-related proteins in midbrain, such as DMT1+IRE, heavy chain ferritin (H-ferritin) and light chain ferritin (L-ferritin).	Iron	55-59	ferritin heavy polypeptide 1	Mus musculus	141-151
35603634-4	2022	Momelotinib is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of hepcidin expression and increased availability of iron for erythropoiesis.	Iron	145-149	activin A receptor type 1	Homo sapiens	59-64
35616167-0	2022	Hepatic STAMP2 alleviates polychlorinated biphenyl-induced steatosis and hepatic iron overload in NAFLD models.	Iron	81-85	STEAP4 metalloreductase	Homo sapiens	8-14
35613428-2	2022	Currently, the widely accepted mechanisms of the anti-inflammatory effects for Ga3+ are rationalized on the basis of their similarities to ferric ions (Fe3+), which permits Ga3+ to bind with Fe-binding proteins and subsequently disturbs the Fe homeostasis in the immune cells.	Iron	191-193	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	79-82
35613428-2	2022	Currently, the widely accepted mechanisms of the anti-inflammatory effects for Ga3+ are rationalized on the basis of their similarities to ferric ions (Fe3+), which permits Ga3+ to bind with Fe-binding proteins and subsequently disturbs the Fe homeostasis in the immune cells.	Iron	191-193	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	173-176
35613428-2	2022	Currently, the widely accepted mechanisms of the anti-inflammatory effects for Ga3+ are rationalized on the basis of their similarities to ferric ions (Fe3+), which permits Ga3+ to bind with Fe-binding proteins and subsequently disturbs the Fe homeostasis in the immune cells.	Iron	241-243	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	79-82
35613428-2	2022	Currently, the widely accepted mechanisms of the anti-inflammatory effects for Ga3+ are rationalized on the basis of their similarities to ferric ions (Fe3+), which permits Ga3+ to bind with Fe-binding proteins and subsequently disturbs the Fe homeostasis in the immune cells.	Iron	241-243	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	173-176
35549246-5	2022	The Fe ions inserted between TaS2 vdW layers with very weak bonding with TaS2 vdW layer, are the origin of the ferromagnetism and give rise to its weak electron-spin and spin-phonon couplings which in turn lead to the observed abnormal hot carrier decay in the ferromagnetic phase Fe1/3TaS2.	Iron	4-6	spindlin 1	Homo sapiens	161-165
35549246-5	2022	The Fe ions inserted between TaS2 vdW layers with very weak bonding with TaS2 vdW layer, are the origin of the ferromagnetism and give rise to its weak electron-spin and spin-phonon couplings which in turn lead to the observed abnormal hot carrier decay in the ferromagnetic phase Fe1/3TaS2.	Iron	4-6	spindlin 1	Homo sapiens	170-174
35598199-4	2022	METHODS AND RESULTS: Proteomic analyses found that ATO can affect the signaling pathway associated with ferroptosis, including the upregulation of iron absorption (FTL, FTH1, HO-1), ferritinophagy (LC3, P62, ATG7, NCOA4) and modifier of glutathione synthesis (GCLM); downregulation of glutamine synthetase (GS) and GPX4, which was the critical inhibitor of ferroptosis.	Iron	147-151	ferritin light chain	Homo sapiens	164-167
35247217-0	2022	Tuning the Spin State of the Iron Center by Bridge-Bonded Fe-O-Ti Ligands for Enhanced Oxygen Reduction.	Iron	29-33	spindlin 1	Homo sapiens	11-15
35247217-2	2022	Hereon, we provide an axial Fe-O-Ti ligand regulated spin-state transition strategy to improve the oxygen reduction reaction (ORR) activity of Fe centers.	Iron	143-145	spindlin 1	Homo sapiens	53-57
35247909-6	2022	The upregulation of IDO1 in cancer cells acted as an immunosuppressive feedback mechanism to limit the proliferation and function of cytotoxic CD8+ T lymphocytes through iron-dependent kynurenine production and subsequent TSPAN5-mediated kynurenine secretion.	Iron	170-174	tetraspanin 5	Mus musculus	222-228
35588886-4	2022	Interestingly, we found that Fe3+ derived from rust, waste iron or Fe3+ reagents can be used as the electron transport medium to solve the electron transport obstacles between red P and Cr6+.	Iron	59-63	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	186-189
35411952-4	2022	We performed temporal metabolomics on mammalian cells treated with deferiprone, a therapeutic iron chelator that stimulates PINK1/PARKIN-independent mitophagy.	Iron	94-98	PTEN induced kinase 1	Homo sapiens	124-129
35437988-4	2022	The synergetic mechanism is further found to be broadly applicable in O2 adsorption on magnetic X2C18H12 (X = Mn, Fe, Co, and Ni) with a well-defined linear scaling dependence between the chemical activity and spin excitation energy.	Iron	114-116	spindlin 1	Homo sapiens	210-214
35522454-0	2022	Local Spin-state Tuning of Iron Single-Atom Electrocatalyst by S-coordinated Doping for Kinetics-boosted Ammonia Synthesis.	Iron	27-31	spindlin 1	Homo sapiens	6-10
35599858-10	2022	We determined that iron distribution is modified in abi3, lec2, and fus3 embryo mutants.	Iron	19-23	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	68-72
35599858-11	2022	For abi3-6 and fus3-3 mutant embryos, iron was less accumulated in vacuoles of cells surrounding provasculature compared with wild type embryos.	Iron	38-42	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	15-19
35599858-15	2022	Altogether our results support a role of the B3 transcription factors ABI3, LEC2, and FUS3 in maintaining iron homeostasis in Arabidopsis embryos.	Iron	106-110	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	86-90
35513392-7	2022	GxG analysis highlights a buffering interaction between the iron transporter SLC25A37 (A37) and the poorly characterized SLC25A39 (A39).	Iron	60-64	solute carrier family 25 member 37	Homo sapiens	77-85
35563497-11	2022	These findings point at areas for further investigation in a higher eukaryotic model of VPS13-related diseases and to new therapeutic targets: calcium signalling and copper and iron homeostasis.	Iron	177-181	membrane morphogenesis protein VPS13	Saccharomyces cerevisiae S288C	88-93
35499603-6	2022	Hepcidin is expressed in beta cells and serves as the key regulator of iron homeostasis.	Iron	71-75	hepcidin antimicrobial peptide	Mus musculus	0-8
35499081-6	2022	The subsequent loss of BDH2 drove labile iron to accumulate in the cytoplasm and promoted TET enzyme activity, BCL6 gene demethylation, and Tfh cell differentiation.	Iron	41-45	BCL6 transcription repressor	Homo sapiens	111-115
35499081-7	2022	This work identifies a role for iron in CD4+ T cell biology and the development of pathogenic effectors in SLE.	Iron	32-36	CD4 antigen	Mus musculus	40-43
35124415-6	2022	We determined the level of intracellular free iron in CD4+ T cells by PGSK probe and examined the expression of the Fth and Tfrc genes by qPCR.	Iron	46-50	CD4 antigen	Mus musculus	54-57
35487763-1	2022	Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes.	Iron	86-90	RoBo-1	Rattus norvegicus	59-63
35487763-1	2022	Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes.	Iron	86-90	RoBo-1	Rattus norvegicus	108-112
35487763-1	2022	Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes.	Iron	165-169	RoBo-1	Rattus norvegicus	59-63
35473528-5	2022	The migration ability of iron-carrying macrophages was confirmed by an in vitro migration experiment and monocyte chemoattractant protein-1 detection.	Iron	25-29	chemokine (C-C motif) ligand 2	Mus musculus	105-139
35473528-6	2022	The release of iron from macrophages was confirmed by determining their levels in the cell culture supernatant, and we constructed a high expression of ferroportin strain of macrophage lines to increase intracellular iron efflux by increasing membrane transferrin expression.	Iron	217-221	transferrin	Mus musculus	252-263
35517793-1	2022	Background: Erythroferrone (ERFE) is a hormone identified recently as a master regulator connecting iron homeostasis and erythropoiesis.	Iron	100-104	erythroferrone	Rattus norvegicus	28-32
35530281-11	2022	Other upregulated proteins for overexpressed JTB condition are involved in multiple cellular functions and pathways that become dysregulated, such as tumor microenvironment (TME) acidification, the transmembrane transport pathways, glycolytic flux, iron metabolism and oxidative stress, metabolic reprogramming, nucleocytosolic mRNA transport, transcriptional activation, chromatin remodeling, modulation of cell death pathways, stress responsive pathways, and cancer drug resistance.	Iron	249-253	jumping translocation breakpoint	Homo sapiens	45-48
35592205-1	2022	Methemoglobin (MetHb) is a form of hemoglobin in which iron in Hb is in an oxidized form (ferric) instead of ferrous, making it difficult to bind with oxygen.	Iron	55-59	hemoglobin subunit gamma 2	Homo sapiens	0-13
35278406-11	2022	In addition, IONP@PTX inhibited the capacity of cell migration and invasion, increased the levels of iron ions, ROS and lipid peroxidation, enhanced the expression of autophagy-related protein Beclin1 and LC3II, and suppressed the expression of p62 and ferroptosis-related protein GPX4 in vitro compared with control group.	Iron	101-105	nucleoporin 62	Homo sapiens	245-248
35262627-0	2022	Iron out KRAS-driven cancer.	Iron	0-4	KRAS proto-oncogene, GTPase	Homo sapiens	9-13
35262627-5	2022	Med.https://doi.org/10.1084/jem.20210739) leveraged KRAS-induced iron addiction in cancer cells to design a clever drug delivery approach to enable selective inhibition of KRAS signaling in mutant KRAS tumors but not in normal tissues, offering a new strategy for treating this largely incurable disease.	Iron	65-69	KRAS proto-oncogene, GTPase	Homo sapiens	52-56
35262627-5	2022	Med.https://doi.org/10.1084/jem.20210739) leveraged KRAS-induced iron addiction in cancer cells to design a clever drug delivery approach to enable selective inhibition of KRAS signaling in mutant KRAS tumors but not in normal tissues, offering a new strategy for treating this largely incurable disease.	Iron	65-69	KRAS proto-oncogene, GTPase	Homo sapiens	172-176
35192961-7	2022	Reduced AKT kinase signaling results in intracellular glucose deprivation, which causes endoplasmic reticulum stress and iron depletion, leading to activation of HIF-1alpha, the transcription factor necessary for higher Glut expression.	Iron	121-125	solute carrier family 2 member 1	Homo sapiens	220-224
35040039-1	2022	Lipocalin-2 (LCN2) is an important regulator of both neuroinflammation and iron homeostasis.	Iron	75-79	lipocalin 2	Homo sapiens	0-11
35040039-1	2022	Lipocalin-2 (LCN2) is an important regulator of both neuroinflammation and iron homeostasis.	Iron	75-79	lipocalin 2	Homo sapiens	13-17
35040039-3	2022	In the present study, we reported iron chelator deferoxamine (DFO) abolished lipopolysaccharide (LPS)-induced LCN2 upregulation in primary astrocytes, although iron overload had no effects.	Iron	34-38	lipocalin 2	Homo sapiens	110-114
35023054-0	2022	Neuropathological Mechanisms of beta-N-Methylamino-L-Alanine (BMAA) with a Focus on Iron Overload and Ferroptosis.	Iron	84-88	DNA polymerase lambda	Homo sapiens	32-38
35378780-1	2022	Purpose: Ferritin is a protein that plays an important role in iron metabolism, it consists of two subunits: heavy chain (FTH) and light chain (FTL).	Iron	63-67	ferritin light chain	Homo sapiens	144-147
35401208-9	2022	Furthermore, an intrathecal injection of SIRT2 overexpressed recombinant adenovirus, which upregulated the expression of SIRT2, attenuated mechanical allodynia, enhanced the level of FPN1, inhibited intracellular iron accumulation, and reduced oxidant stress levels, thereby reversing the changes to ACSL4 and GPX4 expression in the SNI rats.	Iron	213-217	sirtuin 2	Rattus norvegicus	41-46
35401208-9	2022	Furthermore, an intrathecal injection of SIRT2 overexpressed recombinant adenovirus, which upregulated the expression of SIRT2, attenuated mechanical allodynia, enhanced the level of FPN1, inhibited intracellular iron accumulation, and reduced oxidant stress levels, thereby reversing the changes to ACSL4 and GPX4 expression in the SNI rats.	Iron	213-217	sirtuin 2	Rattus norvegicus	121-126
35387233-8	2022	We then demonstrated that this cofactor limitation may be partially recovered by disrupting iron homeostasis with a fra2 mutation, thereby increasing cellular iron levels.	Iron	92-96	Bol2p	Saccharomyces cerevisiae S288C	116-120
35387233-8	2022	We then demonstrated that this cofactor limitation may be partially recovered by disrupting iron homeostasis with a fra2 mutation, thereby increasing cellular iron levels.	Iron	159-163	Bol2p	Saccharomyces cerevisiae S288C	116-120
35258182-2	2022	A total of 16 heavy metal elements (Al, Si, K, Ca, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Ba, Pb, and Cd) in PM1 were continuously determined by an online heavy metal observation instrument in Zhengzhou city from January 7 to 25, 2021.	Iron	62-64	transmembrane protein 11	Homo sapiens	105-108
35182730-4	2022	C19orf12 KO cells and MPAN fibroblast cells demonstrated mitochondrial fragmentation and dysfunction, iron overload and increased oxidative damage.	Iron	102-106	chromosome 19 open reading frame 12	Homo sapiens	0-8
35182730-6	2022	Moreover, C19orf12 KO cells and MPAN fibroblast cells were susceptible to erastin- or RSL3-induced ferroptosis which could be almost completely prevented by pretreatment of iron chelator DFO.	Iron	173-177	chromosome 19 open reading frame 12	Homo sapiens	10-18
35038358-0	2022	Drosophila ZIP13 overexpression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria.	Iron	115-119	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	11-16
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	363-368
35038358-2	2022	To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin.	Iron	15-19	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	370-376
35038358-4	2022	The rescue effects of dZIP13 OE or Tsf1 RNAi were not exerted through mitochondrial disruption or mitophagy, instead, the iron levels in mitochondira were significantly increased, resulting in enhanced activity of enzymes participating in respiration and increased ATP synthesis.	Iron	122-126	Zinc/iron regulated transporter-related protein 99C	Drosophila melanogaster	22-28
35270089-0	2022	Impacts of Mn, Fe, and Oxidative Stressors on MnSOD Activation by AtMTM1 and AtMTM2 in Arabidopsis.	Iron	15-17	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	77-83
35270089-5	2022	However, we showed that BPS inhibited MnSOD activity in AtMTM1 and AtMTM2 single- and double-mutant protoplasts, implying that altered Fe homeostasis affected MnSOD activation through AtMTM1 and AtMTM2.	Iron	135-137	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	67-73
35270089-5	2022	However, we showed that BPS inhibited MnSOD activity in AtMTM1 and AtMTM2 single- and double-mutant protoplasts, implying that altered Fe homeostasis affected MnSOD activation through AtMTM1 and AtMTM2.	Iron	135-137	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	195-201
35270089-6	2022	Notably, we used inductively coupled plasma-optical emission spectrometry (ICP-OES) analysis to reveal an abnormal Fe/Mn ratio in the roots and shoots of AtMTM1 and AtMTM2 mutants under MV stress, indicating the importance of AtMTM1 in roots and AtMTM2 in shoots for maintaining Fe/Mn balance.	Iron	279-281	Myotubularin-like phosphatases II superfamily	Arabidopsis thaliana	165-171
35203218-9	2022	In organic iron supplemented groups, insulin and thyroid hormones levels were significantly increased, and glucose level was significantly decreased.	Iron	11-15	LOC105613195	Ovis aries	37-44
35167013-1	2022	The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH) and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron homeostasis.	Iron	169-173	hephaestin	Homo sapiens	66-76
35167013-1	2022	The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH) and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron homeostasis.	Iron	169-173	hephaestin	Homo sapiens	78-82
35167013-5	2022	CP is particularly important in facilitating iron release from the liver and central nervous system, HEPH is the major MCF in the small intestine and is critical for dietary iron absorption, and ZP is important for normal hair development.	Iron	45-49	hephaestin	Homo sapiens	101-105
35167013-5	2022	CP is particularly important in facilitating iron release from the liver and central nervous system, HEPH is the major MCF in the small intestine and is critical for dietary iron absorption, and ZP is important for normal hair development.	Iron	174-178	hephaestin	Homo sapiens	101-105
35223999-0	2022	Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans.	Iron	46-50	Beta-Carotene 15,15'-MonoOxygenase	Caenorhabditis elegans	70-76
35072463-0	2022	High-Performance Fe-Based Prussian Blue Cathode Material for Enhancing the Activity of Low-Spin Fe by Cu Doping.	Iron	17-19	spindlin 1	Homo sapiens	91-95
35072463-0	2022	High-Performance Fe-Based Prussian Blue Cathode Material for Enhancing the Activity of Low-Spin Fe by Cu Doping.	Iron	96-98	spindlin 1	Homo sapiens	91-95
35072463-5	2022	In addition to few Fe(CN)6 vacancies and low crystal water, the improved performance is also related to the enhanced electrochemical activity of low-spin Fe and the stabilizing effect of Cu on the crystal structure.	Iron	154-156	spindlin 1	Homo sapiens	149-153
35072463-7	2022	As a result, after Cu doping, the initial discharge capacity is enhanced from 107.9 to 127.4 mA h g-1 at 100 mA g-1, especially the capacities contributed by low-spin Fe increase from 30.0, 21.7, and 16.7 mA h g-1 to 48.8, 45.4, and 43.7 mA h g-1 for the first three cycles, respectively.	Iron	167-169	spindlin 1	Homo sapiens	162-166
35404886-2	2022	Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2).	Iron	140-144	lipocalin 2	Homo sapiens	262-266
35163276-10	2022	Combined, the results of our study indicate that there are kidney-specific mechanisms in hepcidin regulation, as indicated by the dominant role of iron and not inflammation as an inducer of renal hepcidin, but also emphasize the complex interplay of various iron regulatory mechanisms during AKI on a local and systemic level.	Iron	147-151	hepcidin antimicrobial peptide	Mus musculus	89-97
35163276-10	2022	Combined, the results of our study indicate that there are kidney-specific mechanisms in hepcidin regulation, as indicated by the dominant role of iron and not inflammation as an inducer of renal hepcidin, but also emphasize the complex interplay of various iron regulatory mechanisms during AKI on a local and systemic level.	Iron	258-262	hepcidin antimicrobial peptide	Mus musculus	89-97
35079622-7	2022	Iron was excessively accumulated in ISCU-deficient skeletal muscle, which was accompanied by a downregulation of IRP1 and mitoferrin2 genes and an upregulation of frataxin (FXN) gene expression.	Iron	0-4	solute carrier family 25 member 28	Homo sapiens	122-133
35291442-17	2022	The lower susceptibility in SCA6 suggests a loss of iron-rich glial cells.	Iron	52-56	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	28-32
35046970-0	2021	Genetic Correlation Between Fe and Zn Biofortification and Yield Components in a Common Bean (Phaseolus vulgaris L.).	Iron	28-30	brain expressed associated with NEDD4 1	Homo sapiens	88-92
35046970-3	2021	Bean is a target for biofortification to develop new cultivars with high Fe/Zn levels that help to ameliorate malnutrition mainly in developing countries.	Iron	73-75	brain expressed associated with NEDD4 1	Homo sapiens	0-4
35088955-4	2022	The neutrophil gelatinase-associated lipocalin (NGAL) is a marker of neutrophil formation and acts as a siderophore-binding protein to prevent bacterial iron uptake and its use as a marker in the diagnosis and follow-up of bacterial infections is being investigated.	Iron	153-157	lipocalin 2	Homo sapiens	4-46
35088955-4	2022	The neutrophil gelatinase-associated lipocalin (NGAL) is a marker of neutrophil formation and acts as a siderophore-binding protein to prevent bacterial iron uptake and its use as a marker in the diagnosis and follow-up of bacterial infections is being investigated.	Iron	153-157	lipocalin 2	Homo sapiens	48-52
35087963-7	2022	The presence of W, W3C as well as the Fe amount variation determined two different micro-galvanic corrosion mechanisms significantly changing the CR of coatings, 0.26 +- 0.02, 59.68 +- 1.21 and 59.06 +- 1.16 mum/year for P100, P200 and P400, respectively.	Iron	38-40	AT-rich interaction domain 2	Homo sapiens	227-231
35087963-7	2022	The presence of W, W3C as well as the Fe amount variation determined two different micro-galvanic corrosion mechanisms significantly changing the CR of coatings, 0.26 +- 0.02, 59.68 +- 1.21 and 59.06 +- 1.16 mum/year for P100, P200 and P400, respectively.	Iron	38-40	E1A binding protein p400	Homo sapiens	236-240